bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain responses to repetition-based rule-learning do not exhibit sex differences: an aggregated analysis of infant fNIRS studies
Authors: Gemignani Jessica , Gervain Judit 
Published: January 2024

AbstractStudies have repeatedly shown sex differences in some areas of language development, typically with an advantage for female over male children. However, the tested samples are typically small and the effects do not always replicate. Here, we used a meta-analytic approach to address this issue in a larger sample, combining seven fNIRS studies on the neural correlates of repetition- and non-repetition-based rule learning in newborns and 6-month-old infants. The ability to extract structural regularities from the speech input is fundamental for language development, it is therefore highly relevant to understand whether this ability shows sex differences. The meta-analysis tested the effect of Sex, as well as of other moderators on infants’ hemodynamic responses to repetition-based (e.g. ABB: “mubaba”) and non-repetition-based (e.g. ABC: “mubage”) sequences in both anatomically and functionally defined regions of interests. Our analyses did not reveal any sex differences at birth or at 6 months, suggesting that the ability to encode these regularities is robust across sexes. Interestingly, the meta-analysis revealed other moderator effects. Thus in newborns, we found a greater involvement of the bilateral temporal areas compared to the frontal areas for both repetition and non-repetition sequences. Further, non-repetition sequences elicited greater responses in 6-month-olds than in newborns, especially in the bilateral frontal areas. When analyzing functional clusters of HbR timetraces, we found that a larger right-left asymmetry for newborn boys in brain responses compared to girls, which may be interpreted in terms of a larger right-left asymmetry in cerebral blood flow in boys than in girls early in life. We conclude that extracting repetition-based regularities from speech is a robust ability with a well-defined neural substrate present from birth and it does not exhibit sex differences.
The association between political orientation and political knowledge in 45 nations
Authors: De keersmaecker Jonas , Schmid Katharina , Sibley Chris G. , Osborne Danny 
Published: January 2024

AbstractPolitical knowledge is crucial for well-functioning democracies, with most scholars assuming that people at the political extremes are more knowledgeable than those at the center. Here, we adopt a data-driven approach to examine the relationship between political orientation and political knowledge by testing a series of polynomial curves in 45 countries (N = 63,544), spread over 6 continents. Contrary to the dominant perspective, we found no evidence that people at the political extremes are the most knowledgeable about politics. Rather, the most common pattern was a fourth-degree polynomial association in which those who are moderately left-wing and right-wing are more knowledgeable than people at the extremes and center of the political spectrum. This pattern was especially, though not exclusively, prevalent in Western countries. We conclude that the relationship between political orientation and political knowledge is more context-dependent and complex than assumed, and caution against (implicit) universal conclusions in social sciences.
Evaluation of the lower extremity functional test to predict lower limb injuries in professional male footballers
Authors: Mohammadi Haniyeh , Ghaffari Raheleh , Kazemi Abdolreza , Behm David G. , Hosseinzadeh Mahdi 
Published: January 2024

AbstractThe Lower Extremity Functional Test (LEFT) is a reliable and valid test for the measurement of athletic fitness, fatigue resistance, and speed performance. Contradictory results exist regarding the screening value of the LEFT in predicting lower limb injuries. The purpose of this study was to investigate the screening value of the LEFT in predicting lower limb injuries in professional male footballers. One hundred and twenty-one professional male football players participated in the study. LEFT was recorded pre-season and the lower-limb injuries were recorded during a 9-month season. Logistic regression analysis was used to determine the accuracy of the prognosis of LEFT. A total of twenty-five lower limb injuries were recorded. The model explained 53% of the variance in lower limb injury, showing that predictions by LEFT score is reliable, and correctly predicted 89.3% of cases, which is a large improvement. ROC analysis showed significant accuracy of the LEFT score (AUC 0.908, 95% CI 1.126–1.336, p = 0.001, OR = 1.227) in discriminating between injured and uninjured players. The optimum cut-off level of the LEFT score was 90.21 s; Our findings showed that the LEFT score was able to predict lower limb injuries in professional male footballers. The slower an athlete’s LEFT scores, the more susceptible they are to future injury risk. Sports medicine specialists, football coaches and managers are suggested to use LEFT as a pre-season screening test to identify and prevent the weakness and functional imbalance of the athletes before the injury occurs by conducting this test.
Global increase in future compound heat stress-heavy precipitation hazards and associated socio-ecosystem risks
Authors: Zhou Zhiling , Zhang Liping , Zhang Qin , Hu Chen , Wang Gangsheng , She Dunxian , Chen Jie 
Published: January 2024

AbstractCompound extremes of lethal heat stress-heavy precipitation events (CHPEs) seriously threaten social and ecological sustainability, while their evolution and effects at the global scale under climate warming remain unclear. Here we develop the global picture of projected changes in CHPEs under various scenarios and investigate their socioeconomic and ecosystem risks combining hazard, exposure, and vulnerability through the composite indicator approach. We find a high percentage of heat stress is followed by heavy precipitation, probably driven by atmospheric conditions. Global average frequency and intensity of CHPEs are projected to increase in the future under high-emission scenarios. Joint return periods of CHPEs are projected to decrease globally, predominantly driven by changes in heat stress extremes. In the long-term future, over half of the population, gross domestic product, and gross primary productivity may face high risk in most regions, with developed regions facing the highest risks under SSP5-8.5 and developing regions facing the highest risks under SSP3-7.0.
Transition to cellular agriculture reduces agriculture land use and greenhouse gas emissions but increases demand for critical materials
Authors: El Wali Mohammad , Rahimpour Golroudbary Saeed , Kraslawski Andrzej , Tuomisto Hanna L. 
Published: January 2024

AbstractCellular agriculture, that is, the production of cultured meat and microbial proteins, has been developed to provide food security for a growing world population. The use of green energy technologies is recommended to ensure the sustainability of changing traditional agriculture to a cellular one. Here, we use a global dynamic model and life-cycle assessment to analyze scenarios of replacing traditional livestock products with cellular agriculture from 2020 to 2050. Our findings indicate that a transition to cellular agriculture by 2050 could reduce annual greenhouse gas emissions by 52%, compared to current agriculture emissions, reduce demand for phosphorus by 53%, and use 83% less land than traditional agriculture. A maximum 72% replacement of livestock products with cellular agriculture using renewable energy is possible based on the 2050 regional green energy capacities. A complete transition can be achieved but requires 33% of the global green energy capacities in 2050. Further, the accelerated demand for critical materials will not exceed their primary production capacities, except for tellurium. We conclude that a transition to cellular agriculture is possible with environmental benefits and provide a benchmark to study different alternatives to animal-based diets.
Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy
Authors: Chen Xue , Wang Ying , Wang Jia-Nan , Zhang Yi-Chen , Zhang Ye-Ran , Sun Ru-Xu , Qin Bing , Dai Yuan-Xin , Zhu Hong-Jing , Zhao Jin-Xiang , Zhang Wei-Wei , Ji Jiang-Dong , Yuan Song-Tao , Shen Qun-Dong , Liu Qing-Huai 
Published: January 2024

AbstractDiabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine (m6A) demethylase that demethylates RNAs involved in energy homeostasis, though its influence on DR is not well studied. Herein, we detected elevated FTO expression in vitreous fibrovascular membranes of patients with proliferative DR. FTO promoted cell cycle progression and tip cell formation of endothelial cells (ECs) to facilitate angiogenesis in vitro, in mice, and in zebrafish. FTO also regulated EC-pericyte crosstalk to trigger diabetic microvascular leakage, and mediated EC–microglia interactions to induce retinal inflammation and neurodegeneration in vivo and in vitro. Mechanistically, FTO affected EC features via modulating CDK2 mRNA stability in an m6A-YTHDF2-dependent manner. FTO up-regulation under diabetic conditions was driven by lactate-mediated histone lactylation. FB23-2, an inhibitor to FTO’s m6A demethylase activity, suppressed angiogenic phenotypes in vitro. To allow for systemic administration, we developed a nanoplatform encapsulating FB23-2 and confirmed its targeting and therapeutic efficiency in mice. Collectively, our study demonstrates that FTO is important for EC function and retinal homeostasis in DR, and warrants further investigation as a therapeutic target for DR patients.
An interleaved high step‐up DC–DC converter based on coupled‐inductor
Authors: Karimi Kamran , Babaei Ebrahim , Karimi Mehran , Alizadeh Darioush , Mousavi Seyyed Mohammad Javad 
Published: January 2024

AbstractThis paper proposes an interleaved coupled‐inductor high step‐up direct current (DC)–DC converter. This converter uses a coupled inductor (CI), a voltage multiplier (VM) integrated with a regenerative passive lossless clamp circuit to enhance the voltage conversion ratio. The interleaved structure is used as the front stage of the proposed converter to reduce the input current ripple. The proposed converter has benefits such as low voltage stress across semiconductor elements, high voltage gains, and continuous input current, which makes it suitable for applications such as renewable energy sources. In addition, to reduce the negative effects of leakage inductance and recover the energy stored in it, a diode‐capacitor clamp circuit is used. Moreover, a comprehensive analysis has been done on the details of the performance of the proposed converter in different operation modes. Also, its design, the voltage and current equations of all the elements, and efficiency analysis are obtained. In addition, a comprehensive comparison has been made with some similar converters. The experimental results of a prototype with 260 W 96.9% is presented to validate the performance of the proposed converter.
Rolling‐horizon optimization strategy for wind‐storage system in electricity market
Authors: Chen Ruochen , Gao Ciwei , Ming Hao 
Published: January 2024

AbstractChina's electricity spot market is undergoing rapid development. With the increasing integration of new energy sources, it has become imperative for new energy power plants to participate in the market actively. Simultaneously, new energy power facilities are equipped with energy storage to cope with the randomness of power generation. In order to address the optimization and control challenges of wind‐storage combined systems in the market environment, a charging and discharging strategy is proposed. Considering system parameters as variables, an online rolling‐horizon optimization model for wind‐storage systems is constructed to maximize revenue. Case studies demonstrate that this strategy effectively improves the overall revenue of wind power plants. After optimization, the return on investment (ROI) of the system increases by 2.29%. The selection of system parameters can significantly impact the outcomes. The optimal values of the capacity configuration and step size are 25 MWh and 45 min.
Emetophobie: Die spezifische Phobie des Erbrechens – ein Case
Report
Authors: Eckert Andreas Philipp , Wallner Lisa , Hofstädter Ataraxia Clara-Sophia 
Published: January 2024

ZusammenfassungUnter Emetophobie versteht man eine intensive und irrationale Angst vor dem
Erbrechen. Sie zählt zu den spezifischen Phobien. Die Emetophobie ist
eine bisher noch wenig erforschte Erkrankung. Über Ursachen und
Prävalenz ist nur wenig bekannt, zudem fehlt es an systematisch
gesichertem Wissen zur Behandlung. Die meisten Studien weisen jedoch darauf hin,
dass die Emetophobie überwiegend Frauen betrifft, früh in der
Kindheit beginnt, meist einen chronischen Verlauf nimmt, mit psychischen
Komorbiditäten einhergeht und Betroffene oft aus Scham nicht von ihrem
Leiden berichten. Die kognitive Verhaltenstherapie (KVT) mit Exposition und
Reaktionsmanagement scheint das derzeit wirksamste Therapieverfahren zur
Behandlung der Emetophobie. Wir berichten über den Fall einer
20-jährigen Frau, die initial wegen einer schweren depressiven Episode
zur stationär-psychiatrischen Krankenhausbehandlung aufgenommen wurde.
Das Erkennen der Emetophobie war dadurch erschwert, dass die Patientin aus Scham
nicht spontan über ihre Symptome berichtete. Eine gründliche und
strukturierte Anamneseerhebung ist daher unerlässlich, da Betroffene oft
versuchen, ihre Symptome zu verheimlichen. Aus diesem Grunde wird die Erkrankung
oft übersehen und meist erst spät diagnostiziert und behandelt.
Unsere Patientin beklagte eine starke emotionale Belastung durch die Symptome
der Emetophobie, zeigte Vermeidungs- und Sicherheitsverhalten und war in ihrer
Lebensqualität und allgemeinen Funktionsfähigkeit erheblich
eingeschränkt. Die Symptomatik unserer Patientin besserte sich nach
Beginn der kognitiven Verhaltenstherapie. Diese beinhaltete Wissensvermittlung
durch Psychoedukation, eine Überprüfung und Korrektur
dysfunktionaler Kognitionen, graduierte Expositionen sowie der Aufbau positiver
Selbstwirksamkeitserwartungen. Es besteht weiterer Bedarf an Forschung, um mehr
über dieses noch recht unbekannte Krankheitsbild zu erfahren, das ebenso
viel Leid und psychosoziale Einschränkungen versuchen kann wie andere
schwere psychische Erkrankungen.
I2-Catalyzed Oxidative Acylation of Tertiary Amines via C–N Bond Cleavage
Authors: Ablajan Keyume , Ge Xin , Lei Ping , Su Qin , Pan Ying-Ming 
Published: January 2024

AbstractThe development of catalysts for the amidation of tertiary amines with acyl chlorides through oxidative C–N bond cleavage is rather challenging. By employing iodine as the catalyst, a broad range of aromatic acyl chlorides and tertiary amines are efficiently converted into amides in good yields under mild conditions. A plausible mechanistic pathway is proposed for this transformation and is supported by appropriate control experiments.
Sonographic Predictors of Antepartum Bleeding in Placenta Previa
Authors: Smith Devin D. , Adesomo Adebayo A. , Gonzalez-Brown Veronica M. , Russo Jessica , Shellhaas Cynthia , Costanstine Maged M. , Frey Heather A. 
Published: January 2024

Objective To evaluate the association between sonographic features of placenta previa and vaginal bleeding (VB).
Study Design Retrospective cohort study of women with placenta previa identified on ultrasound between 160/7 and 276/7 weeks gestation. Placental distance past the cervical os (DPO), placental thickness, edge angle, and cervical length (CL) were measured. The primary outcome was any VB and the secondary outcome was VB requiring delivery. Median values of the sonographic features were compared for each of the outcomes using the Mann–Whitney U test. Receiver operating characteristic curves were used to compare the predictive value of sonographic variables markers and to determine optimal cut points for each measurement. Logistic regression was used to estimate the association between each measure and the outcomes while controlling for confounders.
Results Of 149 women with placenta previa, 37% had VB and 15% had VB requiring delivery. Women with VB requiring delivery had significantly more episodes of VB than those who did not require delivery for VB (1.5, interquartile range [IQR] [1–3] vs 1.0 [1–5]; p = 0.001). In univariate analysis, women with VB had decreased CL (3.9 vs. 4.2 cm; p < 0.01) compared with those without. Women with VB requiring delivery had increased DPO (2.6 cm IQR [1.7–3.3] vs. 1.5 cm [1.1–2.4], p = 0.01) compared with those without. After adjusting for confounders, only CL < 4 cm remained independently associated with increased risk of VB (adjusted odds ratio: 2.27, 95% confidence interval [1.12–4.58], p = 0.01). None of the measures were predictive of either outcome (area under the curve < 0.65).
Conclusion Decreased CL may be associated with risk of VB in placenta previa.
Key Points
Risk Profiling In Vitro Fertilization Pregnancies that Develop Placenta Accreta Spectrum
Authors: Modest Anna M. , Einerson Brett D. , Nieto Albaro J. , Shrivastava Vineet K. , Shamshirsaz Alireza A. , Shainker Scott A. ,   on behalf of the Pan American Society for Placenta Accreta Spectrum
Published: January 2024

Objective The objective of this study is to assess whether, among a cohort of placenta accreta spectrum (PAS) patients, antenatal suspicion of PAS was less likely in in vitro fertilization (IVF) compared with non-IVF patients. In addition, we aimed to assess whether IVF patients exhibited similar risk factors for PAS compared with non-IVF patients.
Study Design This is an international multicenter retrospective study of patients with pathologically confirmed PAS (accreta, increta, percreta) between 1998 and 2021. PAS patients were identified through a central international PAS database. Antenatal and pathological criteria are specific to each institution. Pregnancies that resulted from IVF were compared with non-IVF pregnancies. Comparisons were made using a chi-square or Fisher's exact test for categorical variables and Wilcoxon rank-sum test for continuous variables.
Results Of the 692 pregnancies included, 44 were in the IVF group and 648 were in the non-IVF group. The IVF group was less likely to have had a prior cesarean delivery (70.5 vs. 91%, p < 0.01) but a similar prevalence of placenta previa (63.6 vs. 68.1%, p = 0.12) compared with the non-IVF group. The IVF group was also less likely to have either a prior cesarean delivery or placenta previa than the non-IVF group (79.5 vs. 95.4%, p < 0.01). Antenatal detection of PAS was less common in the IVF group compared with the non-IVF group (40.9 vs. 60.5%, p < 0.01, respectively), even when adjusted for maternal age, prior cesarean delivery, prior uterine surgery, placenta previa and site (risk ratio: 0.70, 95% confidence interval: 0.62–0.81). The IVF group had less severe pathological disease compared with the non-IVF group (p = 0.02).
Conclusion Pregnant people with PAS who underwent IVF are less likely to have an antenatal suspicion compared with non-IVF patients. This finding may be explained by the lower incidence of prior cesarean deliveries and/or placenta previa as well as less severe forms of PAS.
Key Points
The Hidden Risks of Perioperative Transfusions in Traumatic Lower Extremity Free Flap Reconstruction
Authors: Swiekatowski Kylie R. , Manisundaram Arvind D. , Woods Delani E. , Green Jackson C. , Bhadkamkar Mohin A. , Wu-Fienberg Yuewei 
Published: January 2024

Abstract
Background Blood transfusions have been associated with surgical complications; however, these studies are not specific to lower extremity (LE) reconstruction. We evaluated the effect of perioperative packed red blood cell (PRBC) transfusions on LE free flap outcomes in trauma patients.
Methods Patients undergoing LE free flap reconstruction following acute injuries from 2016 to 2021 were retrospectively analyzed. The perioperative period for transfusions was defined as ± 3 days from the procedure. Parameters included demographics, perioperative characteristics, and outcomes. Major complications were complications requiring reoperation. Univariate and multivariate analyses were performed to identify associations.
Results Of the 205 patients, 48% received PRBCs perioperatively. There was a trend toward higher major complications rate in the transfusion group (19 vs. 10%, p = 0.09). Wound size, injury severity score (ISS), and intraoperative estimated blood loss were greater in the transfusion group (p < 0.01). Preoperative hemoglobin/hematocrit were lower in the transfusion group (p < 0.001). Units of PRBCs transfused were independently associated with major complications on multivariate analysis (odds ratio [OR] = 1.34, confidence interval [CI]: 1.06–1.70, p = 0.015) and length of hospital stay (LOS; OR = 1.05, CI: 1.02–1.08, p = 0.002). Infection, wound size, ISS, and preoperative hemoglobin/hematocrit were independently associated with increased LOS (p < 0.05) but not with major complications.
Conclusion The number of units of PRBCs given perioperatively was the only variable independently associated with major complications on multivariate analysis and was one of many variables associated with increased LOS. These findings suggest the usage of restrictive transfusion protocols in trauma patients requiring LE reconstruction.
Infant Mortality Categorized by Birth Weight Percentiles for Deliveries between 22 and 28 Weeks of Gestation
Authors: Onishi Kazuma , Bitas Christiana , Kawakita Tetsuya 
Published: January 2024

Objective Our objective was to describe infant mortality within 1 year of life according to gestational age and birth weight percentile in infants delivered between 22 and 28 weeks of gestation.
Study Design This study was a retrospective cohort study based on publicly available U.S. birth certificate data linked to infant death data between 2014 and 2020. Maternal–neonate pairs of singleton live births between 220/7 and 286/7 weeks' gestation (vaginal or cesarean) were evaluated. We excluded infants with major fetal anomalies, chromosomal disorders, and birth weight outliers. Our primary outcome was infant mortality within 1 year of life. Individuals were categorized into eight sex-specific birth weight percentiles categories: less than the 3rd, 3rd-less than the 10th, 10th-less than the 25th, 25th-to less than the 50th, 50th-less than the 75th, 75th-to less than the 90th, 90th-less than the 97th, and 97th or higher.
Results Of 27,014,444 individuals with live births from January 2014 to December 2020, 151,677 individuals who gave birth at 22 to 28 weeks of gestation were included in the study population. The mortality rate ranged from 4.2% for the 50th-less than the 75th percentiles at 28 weeks to 80.3% for the 3rd-less than the 10th percentile at 22 weeks. Using the 50th-less than the 75th birth weight percentile at each gestational age as a reference group, birth weight less than the 50th percentile was associated with increased mortality at all gestational ages in a dose-dependent manner. From 22 to 25 weeks of gestation, higher birth weight percentiles were associated with lower mortality, while the 97th or higher birth weight percentile was associated with increased mortality compared with the 50th-less than the 75th birth weight percentile at 26 to 28 weeks of gestation.
Conclusion The lower birth weight percentiles were associated with higher mortality across all gestational ages, but the association between higher birth weight percentiles and infant mortality exhibited an opposite pattern at 22 to 25 weeks as compared to later gestational age.
Key Points