bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variation and driving factors analysis of Greenland ice sheet mass based on GRACE combination model data
Authors: Shen Yi , Tao Zhen , Bian Yankai , Li Zhen 
Published: January 2024

Abstract
In recent years, the increasing mass loss of the Greenland Ice Sheet (GrIS) has a profound impact on the global sea level and climate change. Although some studies have investigated the rate and acceleration of mass loss in GrIS, research on its seasonal variation is relatively limited. In this regard, we firstly use Gravity Recovery and Climate Experiment (GRACE) multi-sourced data to estimate the GrIS mass changes from January 2003 to December 2016. Then, we study the annual variations of ice sheet mass and its driving factors (Modèle Atmosphérique Régionale 3.9 model variables and ice discharge) through singular spectrum analysis (SSA) and wavelet transform analysis. Results show the following: (1) Based on the generalized three-cornered hat method (TCH), the ice sheet mass change obtained from the combined data from different mechanisms, the seasonal annual amplitude variation extracted by SSA is within 200 Gt. (2) In terms of the seasonality, it is also found that the dominant factor of the GrIS mass change is runoff (RU) and ice melt (ME), while snowfall (SF) and rainfall (RF) have little effect on it. Among them, the mean annual amplitudes of the RU and ME are 1.1 and 1.5 times of GRACE respectively, and are not in phase with GRACE. (3) Through the analysis of relative phase and phase approximation, GRACE-derived data has an annual oscillation period with the RU, ME and RF, which lags their phases by 5.2, 5.4 and 4.7 months, respectively, while SF takes only 1.8 months. In addition, the average phase approximation values of the ME and GRACE are larger than those of the RU and RF, while that of the SF is positive. The change trend of the SF is basically opposite to that of the ME, RU and RF, and only consistent in the period 2006–2012.
Targeting CCL5 attenuates fibrosis via activation of PI3k/Akt signaling axis after glaucoma filtration surgery
Authors: Bi Qingyun , Wei Ran , Li Xinying , Zhu Baixue 
Published: January 2024

Abstract
Background.
Glaucoma filtration surgery (GFS) stands as a paramount clinical intervention for glaucoma. Nonetheless, the prevalent cause of GFS failure is filtration bleb scarring, and the role of inflammation and immune response in contributing to fibrosis remains elusive.
Methods.
The study employed 30 female Sprague-Dawley rats (8 weeks old, 200-250g) to assess the anti-scarring impact of the Chemokine (C-C motif) receptor 5 (CCR5)-Chemokine (C-C motif) ligand 5 (CCL5) antibody after GFS. Additionally, anti-fibrotic effects on HConFs were examined, creating an intra-operative inflammatory response using damaged-HConFs supernatant medium (DHSM). In vitro and in vivo validation aimed to elucidate the potential anti-fibrotic molecular mechanism of the CCR5-CCL5 antibody.
Results.
The CCR5-CCL5 antibody effectively prolonged filtration bleb duration and enhanced the functionality of the filtered bleb. Improved postoperative intraocular pressure values (IOP) and morphological images were observed in the CCR5-CCL5 antibody-treated group. Histochemical staining and cellular experiments confirmed the antifibrotic function of the CCR5-CCL5 antibody. Notably, M2-type macrophage polarization was reduced in the CCR5-CCL5 antibody-treated model. CCL5-induced fibrosis in HConFs was mediated through the PI3K/Akt signaling pathway. Consistently, inhibition of PI3K/Akt significantly attenuated the profibrotic effects of CCR5-CCL5. Mechanistically, the CCL5 antibody exerts its antifibrotic effect by targeting CCR5 on HConFs, leading to the inhibition of the PI3K/Akt mechanism.
Conclusion.
This study unveils that CCR5-CCL5 promotes fibrosis in GFS through inflammatory stimulation of HConFs and enhanced activation of the PI3K/Akt signaling pathway. The findings suggest that intraoperative CCR5-CCL5 antibody treatment could serve as a cost-effective therapeutic agent or a useful adjuvant in preventing ocular bleb scar formation.
Biomarkers of Gastrointestinal Nematodes in Beef Cattle Raised in a Tropical Area
Authors: Rodrigues Vinícius Duarte , Borges Dyego Gonçalves Lino , Conde Mário Henrique , de Freitas Mariana Green , Ramos Carlos Alberto do Nascimento , de Souza Alda Izabel , Reckziegel Guilherme Henrique , Rodrigues Daniel de Castro , Borges Fernando de Almeida 
Published: January 2024

Abstract

Biomarkers are specific molecular, histological or physiological characteristics of normal or pathogenic biological processes and are promising in the diagnosis of gastrointestinal nematodes (GINs). Although some biomarkers have been validated for infection by Ostertagia sp. in cattle raised in temperate regions, there is a lack of information for tropical regions. The aim of this project was to assess potential biomarkers and validate the most promising. In the first study, 36 bovines (Nelore breed) naturally infected by GINs were distributed into two groups: CON-A (control, not treated with anthelmintic) and TREAT-A (treated with fenbendazole on Days 0, 7, 14, 21, 28, 42 and 56). The variables of interest were live weight, fecal egg count, hemogram, serum biochemical markers, phosphorus, gastrin and pepsinogen. In the second step, pepsinogen was assessed in cattle of the Nelore breed distributed among three groups: CON-BC (control, not treated with anthelmintic), TREAT-B (treated with moxidectin) and TREAT-C (treated with ivermectin + albendazole). In the first study, no difference between groups were found for weight, albumin, hematocrit (corpuscular volume [CV]), erythrocytes or hemoglobin. Negative correlations were found between pepsinogen and both CV and albumin, and albumin was negatively correlated with the percentage of Haemonchus sp. in the fecal culture. Among the biomarkers, only pepsinogen differentiated TREAT-A and CON-A (beginning with the 28th day of the study). In the second study, a reduction in pepsinogen was found after anthelmintic treatment. Therefore, pepsinogen is a promising biomarker of worms in cattle naturally infected by the genera Haemonchus and Cooperia in tropical areas.
Improving the Photoelectric Conversion Efficiency of Cs2TiBr6-based Perovskite Solar Cells Using a Theoretical Simulation Method
Authors: Wang TingFeng , Li Shuang , Wang Hong-En 
Published: January 2024

Abstract

While lead-based perovskites stand out as a highly promising material for solar cells, there remains a notable concern related to the possibility of lead leakage. This study utilized the solar cell simulation software (SCAPS-1D) to explore strategies for enhancing the efficiency of lead-free perovskite solar cells and to elucidate the corresponding theoretical mechanisms. A model of the n-i-p FTO/TiO2/Cs2TiBr6/P3HT/Au structure was developed. Employing various modification strategies in experimental setups, the impact of crucial parameters on device performance was investigated by manipulating specific variables. This systematic approach allowed for the identification of the most optimal parameter configuration for enhanced device performance. The device performance was thoroughly examined by evaluating key parameters such as transport layer mobility, energy level matching properties, interface defect concentration, interface capture cross-section area, and perovskite defect concentration/thickness. The investigation revealed that a substantial enhancement in device performance can be achieved by minimizing the defect concentration in the perovskite, augmenting the mobility of the transport layer, refining the energy level alignment with the perovskite, and reducing the interface capture area. The device simulation ultimately resulted in a conversion efficiency of 16.86%. This study provides valuable guidelines for the research and development of novel lead-free double perovskite solar cells.
Counter-pulsation Control of a Pulsatile Extracorporeal Membrane Oxygenator Device using Deep Neural Networks for Blood Pressure Waveform Analysis
Authors: Jang Hyunwoo , Yoo Changyoung , Kang Seongmin , Choi Seong Wook 
Published: January 2024

Abstract
The counter-pulsation (CP) control of Pulsatile Extracorporeal Membrane Oxygenator(p-ECMO) contributes to reducing the risks associated with conventional ECMO, such as Left Ventricular dilatation and pulmonary edema. To achieve CP between p-ECMO and the heart, it is crucial to detect heartbeats and p-ECMO pulses in blood pressure (BP) waveform data, especially in cases where ECG measurement is challenging. This study aims to develop an algorithm utilizing deep neural network (DNN) to differentiate heartbeats from other pulses caused by p-ECMO, reflections, or motion artifacts in BP data, ensuring accurate CP control. A mock circulation system, replicating human BP waveforms with a heart model was connected to p-ECMO. Two trained DNNs were employed to measure the heart model's heart rate (HR) and evaluate whether p-ECMO operated in CP mode. In asynchronous mode experiments, the frequency of unintentionally occurring CP was only 25.75%. However, when utilizing the proposed algorithm, stable CP was observed, even when the initial pulse rate of p-ECMO differed from that of the heart model. Notably, even when the heart model changed its HR by 5 bpm every minute for 8 minutes within the range of 55 to 75 bpm, the CP success rate remained above 78%.
Suspected Duloxetine-induced restless legs syndrome phenotypic variant: a case report
Authors: Shao Yan , Chen Yi , Wang Shichang , Li Chaowei , Sun Hongqiang , Sun Xinyu 
Published: January 2024

Abstract

Background: Restless arms syndrome (RAS) is the most common variant of restless legs syndrome (RLS), which is easy to be ignored in clinical practice due to the lack of specific diagnostic criteria. When effective therapeutic agents induced RAS and symptoms persisted after briefly observation, clinicians will face the challenge of weighing efficacy against side effects.
Case presentation:A 67-year-old woman was admitted to a geriatric psychiatric ward with depression. Upon admission, the escitalopram dose was reduced from 15 mg to 10 mg per day, and the duloxetine dose was increased from 60 mg to 80 mg per day. The next night before bedtime, she developed itching and creeping sensations deep inside bilateral shoulders and arms, with the urge to move, worsening at rest, and alleviation after hammering. The symptoms persisted when escitalopram was discontinued. A history of RLS was confirmed. Treatment with 40 mg of duloxetine and 0.125 mg of pramipexole significantly improved depression, and the paresthesia disappeared, with no recurrence occurring 6 months after discharge.
Discussion and conclusions: This case suggests that psychiatrists should pay attention to RLS variants when increasing doses of duloxetine. Long-term improvement can be achieved through dosage reduction combined with dopaminergic drugs instead of immediate discontinuation.
Sagittal knee gait changes after medial unicompartmental and total knee arthroplasty – an exploratory analysis of 36 patients
Authors: Hald Julius , Mortensen Jacob , Gleipner-Andersen Emil , Lehmann Leah , Haugaard Asger , Scheike Thomas , Odgaard Anders 
Published: January 2024

Abstract

This study aimed to investigate postoperative developments of sagittal knee gait in a population of knee arthroplasty patients randomized to either unicompartmental or total knee arthroplasty. We hypothesized that knee arthroplasty patients develop greater walking speeds, range of motion, sagittal knee angle velocities, and sagittal knee angle accelerations. 36 patients were recruited from a randomized trial comparing the two implant types. Sagittal knee gait was examined preoperatively, four, and twelve months postoperatively. The examination used inertial measurement units. Nine gait parameters were defined focusing on knee angles, angular velocities, and accelerations. Stride frequency increased by 0.2 s− 1. Walking speed increased by 0.3 m/s. The range of motion increased by 7 degrees. Extension and flexion velocity during knee swing increased by 72 and 49 degrees/second. Acceleration during flexion increased by 565 degrees/second2. Acceleration during extension increased by 1168 degrees/second2. Acceleration after heel strike increased by 1549 degrees/second2. We observed significant developments in sagittal knee gait after knee arthroplasty. Patients developed faster walking speed and greater stride frequency, as well as improvements in range of motion, sagittal knee angle velocities, and accelerations.
Generalized Sampling Expansion for the Quaternion Linear Canonical Transform
Authors: Siddiqui Saima , Li Bingzhao , Samad Muhammad Adnan 
Published: January 2024

Abstract
The theory of quaternions has gained firm ground in recent times and is being widely explored, with the field ofsignal and image processing being no exception. However, many important aspects of quaternionic signals are yet tobe explored, particularly the formulation of Generalized Sampling Expansions (GSE). In the present article, our aim is to formulate the GSE in the realm of a one-dimensional quaternion linear canonical transform (QLCT). To facilitate the intent, we construct a set of quaternion-valued filter functions which are used to construct a system of equations determining the synthesis functions for the process of reconstruction. Besides, as a special case, another sampling formula involving the derivatives of the quaternionic signal is also obtained in the sequel. Since derivatives contain information about the edges and curves appearing in images, therefore, by invoking the higher degrees of freedom pertaining to QLCT, the obtained sampling formula can be used to develop new image scaling algorithms with state-of-the-art flexibility. As an endorsement of the obtained results, an example with simulations demonstrating the signal reconstruction is presented at the end.
Gold Nanostructure-Enhanced Immunosensing: Ultra-Sensitive Detection of VEGF Tumor Marker for Early Disease Diagnosis
Authors: Yarjoo Sadaf , Siampour Hossein , Khalilipour Mehrsa , Sajedi Reza H. , Bagheri Hassan , Moshaii Ahmad 
Published: January 2024

Abstract

We present an advanced electrochemical immunosensor designed for precise detection of the Vascular Endothelial Growth Factor (VEGF). The sensor is constructed on a modified porous gold electrode through a fabrication process involving the deposition of silver and gold on an FTO substrate. Employing thermal annealing and a de-alloying process, the silver is eliminated from the electrode, resulting in a reproducible porous gold substrate. Utilizing a well-defined protocol, we immobilize the heavy-chain (VHH) antibody against VEGF on the gold substrate, facilitating VEGF detection through various electrochemical methods. Remarkably, this immunosensor achieves an outstanding performance, featuring an impressive detection limit of 0.1pg/ml and an extensive linear range from 0.1pg/ml to 0.1µg/ml. This emphasizes its exceptional ability to precisely measure biomarkers across a wide concentration spectrum. The robust fabrication methodology employed in this research underscores its potential for widespread application, offering enhanced precision, reproducibility, and remarkable detection capabilities for the developed immunosensor.
A pterional dural arteriovenous fistula with a dangerous surprise: the posterior cerebellar artery arising from the middle meningeal artery.
Authors: Lozupone Emilio , Scalise Simona , Trombatore Pietro , Pauciulo Alfredo , Direnzo Vita , Signorelli Francesco , Barbarini Leonardo , Paladini Adriana 
Published: January 2024

Abstract
We describe a case of an adult patient with a left temporal hematoma due to a dural arteriovenous fistula (DAVF) of the pterion. The left middle meningeal artery (MMA) was the major feeding artery of the DAVF and was also supporting the territory of the ipsilateral posterior inferior cerebellar artery (PICA). This is first case described in the literature of a PICA arising from the MMA. Accurate knowledge of vascular anatomy and its variations is essential for the endovascular treatment of cerebrovascular diseases. A complete diagnostic angiography is crucial to plan the correct endovascular strategy and to minimize the risk of complications.
Effect of the plant growth-promoting bacteria strain Bacillus mojavensis I4 on potato growth, physiology, tuber yield and quality under salt stress conditions
Authors: Ghidawi Jaweher Sdiri , Ghazala Imen , Haddar Anissa , Bouazizi Oumaima , Gargouri-Bouzid Radhia , Nouri-Ellouz Oumèma 
Published: January 2024

Abstract

Salinity is one of the major threats to potato. As the first vegetable crop, improving its production under salinity stress is with great interest. In a previous work, Bacillus mojavensis I4 (BmI4) plant growth-promoting (PGP) bacterial strain was isolated from the soil. Since BmI4 showed a growth capacity under salt conditions (10% NaCl) we decided here to evaluate its PGP capacity on potato plants (Spunta and Claustar varieties) grown in the greenhouse in the presence of 100 mM NaCl. Stem elongation and diameter, leaf number, area and organ fresh weights were monitored during 40 days of culture as well as tuber yield, caliber and composition. Our results showed that the inoculation of plantlet roots with BmI4 enhanced plant growth under salinity, particularly for Spunta variety. These beneficial effects were associated with an increase of auxin levels in plants from both varieties. The assessment of H2O2 and malondialdehyde contents revealed that BmI4 inoculation led to reduced oxidation in plants submitted to salinity, via the increase of superoxide dismutase, catalase and peroxidase activities. Moreover, the BmI4 treatment enhanced proline accumulation especially in leaves of Spunta variety. BmI4 inoculated plants from Spunta variety exhibited an early induction of tuberization associated with an increase of tuber yield and caliber under both culture conditions. These findings suggest that inoculation of potato with BmI4 can be promising strategy to improve plant culture in saline areas. Moreover, inoculation improved tuber composition.
A Hospital-Based Survey Assessing the Health Facility-Level Factors that Contribute to Delayed Diagnosis of Cervical Cancer; Patients Views
Authors: Zammit Marthaclaire Kerubo , Nyaberi Jackline , Mambo Susan , Otieno Careena 
Published: January 2024

Abstract
Background In Kenya, Cervical Cancer is the 2nd commonly diagnosed type of cancer and the top cause of cancer-related deaths among women. Globally, over 50% of Cervical Cancer diagnoses are made late, with this proportion rising to 80% in developing countries. Poor Health systems can cause delays in diagnosis, thus, this study focused to determine the health facility level factors that contribute to delayed diagnosis among Cervical Cancer patients at the Kenyatta National Hospital (KNH).Methods An analytical cross-sectional mixed method study was adopted to collect data on hospital and referral experiences from 139 Cervical Cancer patients systematically sampled at KNH, using a semi-structured questionnaire. Associations between stage at diagnosis and hospital and referral experiences were tested using logistic regression model at 95% Confidence Interval.Results 86 (61.9%) were diagnosed at advanced stages III and IV. The risk factors for delayed diagnosis were; more number of referral times (p-value = 0.000), availability of referral challenges (p-value = 0.041), Prolonged diagnosis appointments (p-value = 0.059) and long waiting periods for diagnosis results, (p-value = 0.007), in the bivariate model. Only More number of referral times was significantly associated with delayed diagnosis in the multivariate model (p-value = 0.001). Referral challenges included, misdiagnosis, cost of diagnosis and prolonged diagnosis appointments.Conclusion Advanced stage at presentation for most patients due to poor health and referral systems inadequate medical personnel and diagnosis equipment. Improve referral systems and encourage Public Private Partnerships (PPPs) to decentralize diagnostic centers and equipment and train more expertise on Cervical Cancer
Dual-time-point (DTP) dynamic 68Ga-PSMA-11 PET/CT for parametric imaging generation in prostate cancer
Authors: Burasothikul Paphawarin , Navikhacheevin Chatchai , Pasawang Panya , Sontrapornpol Tanawat , Sukprakun Chanan , Khamwan Kitiwat 
Published: January 2024

Abstract

Purpose: To investigate the optimal dual-time-point (DTP) approaches using dynamic 68Ga-PSMA-11 PET/CT imaging to generate parametric images for patients diagnosed with prostate cancer.
Methods: Fifteen prostate cancer patients were intravenously administered 68Ga-PSMA-11 of 181.9 ± 47.2 MBq, and immediately acquired a 60-min dynamic PET/CT scan. List-mode data were reconstructed into 25 time-frames: 6 × 10 s, 8 × 30 s, 11 × 300 s, and were corrected for motion and partial volume effect. The DTP parametric imaging was generated using different interval time points of 5 min and 10 min, separated by a minimum time interval of 30 min. Net influx rates (Ki) were calculated through the fitting of a single irreversible two-tissue compartmental model. Intraclass correlation coefficient (ICC) values between DTP protocols and 60-min Ki were calculated. Lesion-to-background ratios (LBRs) of Ki images and standardized uptake value (SUV) images in each DTP protocol were determined.
Results: The DTP protocol of 5-10 min with 40-45 min showed the highest ICC of 0.988 compared to the 60-min Ki whereas the ICC values for the 0-5 min with 55-60 min and 0-10 min with 50-60 min intervals were 0.941. The LBRs of 60-min Ki, 5-10 min with 40-45 min Ki, 0-5 min with 55-60 min Ki, 0-10 min with 50-60 min Ki, SUVmean, and SUVmax images were 29.53 ± 27.33, 13.05 ± 15.28, 45.15 ± 53.11, 45.52 ± 70.31, 19.77 ± 23.43, and 25.06 ± 30.07, respectively.
Conclusions: The optimal DTP parametric imaging achieves a comparable Ki to 60-min parametric imaging and exhibits remarkable image quality and contrast compared to SUV imaging, enhancing prostate cancer diagnosis while maintaining time efficiency.