bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN IPTEKS LAS LITRIK DENGAN PENYAMBUNGAN LOGAM UNTUK KEBUTUHAN RUMAH TANGGA BAGI REMAJA PUTUS SEKOLAH DAN PEKERJA BANGUNAN
Authors: Ukiman Ukiman , Pawiro Dadiyono Amat , Nurhadi Imam , Suwarto Suwarto , Suroso Suroso , Yusetyowati Yusetyowati 
Published: November 2023

<em>Penduduk umr 18 tahun sampai dengan 24 tahun di kecamatan Rembang, Kabupaten Rembang kebanyakan mata pencahariannya masih dalam ketidak pastian., misalnya bekerja berpindah pindah di mana yang dapat menghasilkan. Mereka tidak mempunya profesi keahlian tertentu. Dengan kondisi tersebut, maka dapat diasumsikan bahwa masih adnya pengangguran terutama pada remaja putus sekolah.. Banyak bermunculan usaha –usaha pengelasan ,tetapi yang menjadi permasalahan adalah pekerja las listrik yang digunakan masih didatangkan dari luar Rembang. Sehingga hal ini kurang efektif dan tidak efisien untuk pengusaha, karena pengusaha harus menyediakan tempat tinggal untuk pekerja. Dengan harapan pengusaha-pengusaha las listrik tidak kesulitan mecari pekerja , dan kelangkaan tenaga las listrik dapat teratasi dan dapat menekan biaya pengeluaran, serta dapat menyejahterakan masyarakat kalangan bawah yang ada didaerah Rembang dan sekitarnya maka tim pengabdiaan masyarakat Politeknik Negeri Semarang mengadakan kegiatan ini. Metode yang digunakan adalah pelatihan yang meliputi tentang teknik dasar las listrik serta pemotongan menjadi benda jadi sepeti teralis,pintu, daun jendela, rangka atap dan lain sebagainya.</em>
Triangle Manajemen Callus: Zinc Cream, Hydrocoloid dan Polyurethane Foam Pada Pasien Diabetic Neuropathy
Authors: Bahri Khairul , Hidayat Rizki 
Published: November 2023

ABSTRAK Diabetes neuropati adalah kondisi yang disebabkan oleh diabetes yang merusak berbagai bagian sistem saraf. Ini terjadi karena kadar gula dalam darah tinggi yang dapat merusak saraf secara bertahap. Hilang sensasi pada kaki karena neuropati diabetik dapat menyebabkan kapalan akibat tekanan atau gesekan pada kaki. Callus terbentuk di area tubuh yang mengalami gesekan atau tekanan yang berlebihan pada telapak kaki, tumit, atau jari-jari. Gesekan dan tekanan berulang pada kaki adalah beberapa penyebab callus. Salah satu metode pengobatan dan pencegahan callus adalah offloading, yang mengurangi tekanan pada kaki dan mencegah terbentuknya kepalan. Tujuan dari studi kasus ini melihat efektivitas penggunaan zinc cream, hidrokoloid dan polyurethane foam dalam manajemen callus pada pasien dengan diabetic neuropathy. WINNER score sebagai evaluasi penyembuhan luka. Kesimpulan didapatkan dengan hasil Penggunaan zinc cream sebagai balutan primer, hydrocolloid sebagai pelindung sekitar luka dan polyurethane foam sebagai balutan sekunder dan off-loading efektif dalam manajemen callus pada diabetes neuropati. Kata Kunci: Diabetic Neuropati, Callus, Wound Care ABSTRACT Diabetic neuropathy is a condition caused by diabetes that damages different parts of the nervous system. This occurs due to high blood sugar levels that gradually damage the nerves. Loss of sensation in the feet due to diabetic neuropathy can lead to the formation of calluses due to pressure or friction on the feet. Calluses form in areas of the body that experience excessive friction or pressure, such as the soles of the feet, heels, or fingers. Friction and repeated pressure on the foot are some of the causes of calluses. Off-loading is one of the methods used to treat and prevent calluses, which reduces pressure on the legs and prevents calluses from forming. The purpose of this case study was to evaluate the effectiveness of using zinc cream, hydrocolloids, and polyurethane foam in managing calluses in patients with diabetic neuropathy. The WINNER score was used to evaluate wound healing. The results showed that the use of zinc cream as a primary dressing, hydrocolloid as a protector around the wound, polyurethane foam as a secondary dressing, and off-loading was effective in managing calluses in diabetic neuropathy. Keyword: Diabetic Neuropathy, Callus, Wound Care
Efektivitas Media Vidio dan Flipchart Terhadap Tingkat Pengetahuan Siswa Tentang Kesehatan Reproduksi Remaja di Smp Tahta Syajar
Authors: Raihana Ananda Alvi , Futriani Elfira Sri 
Published: November 2023

ABSTRACT The 2015 Global School Health Survey (GSHS) report shows that 3.3% of adolescents aged 15-19 years suffer from AIDS; only 9.9% of women and 10.6% of men aged 15-19 have in-depth knowledge about HIV/AIDS; and 0.7% of women and 4.5% of men had premarital sex. So this raises problems identified in adolescent risk behavior and reproductive health problems. This research was conducted to determine the effectiveness of video media and flipcharts on the level of students' knowledge about adolescent reproductive health at Tahta Syajar Middle School. This research was a quasy experimental study using a pre-post test control group design, namely the research was carried out by making the first observation (pre test) before the intervention was carried out, then a second observation (post test) was carried out after the intervention was carried out. The number of respondents in this study were 36 respondents. There is a difference between the level of knowledge of students and other students, namely by increasing knowledge about reproductive health by providing education through video media and flipcharts. Keywords: Adolescent Reproductive Health, Flipchart, Video ABSTRAK Laporan Global School Health Survey (GSHS) tahun 2015 menunjukkan 3,3% dari remaja usia 15-19 tahun menderita AIDS; hanya 9,9% perempuan dan 10,6% lakilaki berusia 15-19 tahun yang memiliki pengetahuan mendalam tentang HIV/AIDS; dan sebesar 0,7% perempuan dan 4,5% laki-laki telah melakukan hubungan seks pranikah. Sehingga hal ini menimbulkan masalah yang teridentifikasi pada perilaku berisiko remaja dan masalah kesehatan reproduksi. Penelitian ini dilakukan untuk mengetahui Efektivitas media video dan flipchart terhadap tingkat pengetahuan siswa tentang Kesehatan reproduksi remaja di SMP Tahta Syajar. penelitian ini adalah quasy eksperimental dengan menggunakan rancangan control group pre-post test yaitu penelitian dilaksanakan dengan melakukan observasi pertama (pre test) sebelum dilakukan intervensi selanjutnya dilakukan observasi kedua (post test) pada saat setelah dilakukan intervensi. Jumlah responden dalam penelitian ini 36 responden. Ada perbedaan antara tingkat pengetahuan siswa dengan siswa yang lain yaitu dengan meningkatkan pengetahuan tentang Kesehatan reproduksi dengan memberi edukasi melalui media video dan flipchart. Kata Kunci: Kesehatan Reproduksi Remaja, Flipchart, Video
Lung cancer diagnosis and mortality beyond 15 years since quit in individuals with a 20+ pack‐year history: A systematic review
Authors: Kondo Karli K. , Rahman Basmah , Ayers Chelsea K. , Relevo Rose , Griffin Jessica C. , Halpern Michael T. 
Published: November 2023

AbstractCurrent US lung cancer screening recommendations limit eligibility to adults with a pack‐year (PY) history of ≥20 years and the first 15 years since quit (YSQ). The authors conducted a systematic review to better understand lung cancer incidence, risk and mortality among otherwise eligible individuals in this population beyond 15 YSQ. The PubMed and Scopus databases were searched through February 14, 2023, and relevant articles were searched by hand. Included studies examined the relationship between adults with both a ≥20‐PY history and ≥15 YSQ and lung cancer diagnosis, mortality, and screening ineligibility. One investigator abstracted data and a second confirmed. Two investigators independently assessed study quality and certainty of evidence (COE) and resolved discordance through consensus. From 2636 titles, 22 studies in 26 articles were included. Three studies provided low COE of elevated lung cancer incidence beyond 15 YSQ, as compared with people who never smoked, and six studies provided moderate COE that the risk of a lung cancer diagnosis after 15 YSQ declines gradually, but with no clinically significant difference just before and after 15 YSQ. Studies examining lung cancer‐related disparities suggest that outcomes after 15 YSQ were similar between African American/Black and White participants; increasing YSQ would expand eligibility for African American/Black individuals, but for a significantly larger proportion of White individuals. The authors observed that the risk of lung cancer not only persists beyond 15 YSQ but that, compared with individuals who never smoked, the risk may remain significantly elevated for 2 or 3 decades. Future research of nationally representative samples with consistent reporting across studies is needed, as are better data from which to examine the effects on health disparities across different populations.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Nilai-Nilai Karakter Dasa Darma Pramuka pada Pembelajaran PPKn Kelas V SDN 72 Bengkulu Tengah
Authors: Hendriwati Hendriwati , Djuwita Puspa , Hambali Daimun 
Published: November 2023

Abstract This research is motivated by a decrease in the character values of students and the absence of a LKPD that contains the character values of Dasa Darma Pramuka at SDN 72 Bengkulu Tengah. This affects the achievement of learning objectives, namely forming students with character. This study aims to determine the validity and practicality of LKPD based on the values of Dasa Darma Pramuka. This research is a development research using the 4- D model which consists of four stages, namely define, design, develop and disseminate. This research was only conducted until the develop stage, namely the validity test and practicality test. The instrument used was a validity test questionnaire and a practicality test questionnaire. The validity test was carried out by 6 validators, namely 2 material experts, 2 linguists and 2 graphic experts. The practicality test was carried out on 19 students of SDN 72 Bengkulu Tengah. Data from the validity and practicality test results were analyzed by using percentage techniques and processed descriptively. The results of the LKPD validity test based on the values of Dasa Darma by the validator in terms of aspects of the front page, table of contents, study instructions, material feasibility, language presentation, and graphic feasibility, material eligibility was obtained 0.81 with proper criteria, language eligibility results 0, 75 with very feasible criteria and a graphical feasibility result of 0.81. The practicality test results of the LKPD based on the values of the Dasa Darma Pramuka, obtained a value of 80.69 by the teacher and 80.95 by students with practical criteria. Based on the results of the study it can be concluded that the use of LKPD values of Dasa Darma Pramuka SDN 72 Bengkulu Tengah in grade V is very feasible and very practical.Keywords : Dasa Darma, Character, student worksheet
Postoperative acute kidney injury after on-pump cardiac surgery in patients with connective tissue disease
Authors: Zhang Xue , Miao Qi , Yu Chunhua , Zhang Yuelun , Wu Di , Tian Yajie , Li Hanchen , Wang Chunrong 
Published: November 2023

ObjectivePatients with connective tissue disease have a poor prognosis after receiving cardiac surgery. This study described the clinical scenarios and investigated factors correlated with acute kidney injury (AKI) after on-pump cardiac surgery in patients with systemic lupus erythematosus (SLE) or vasculitis.MethodsPatients with SLE or vasculitis who underwent on-pump cardiac surgery from March 2002 to March 2022 were enrolled, while patients with preoperative renal dysfunction were excluded. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Uni- and multivariable analyses were performed to identify potential factors associated with postoperative AKI.ResultsAmong 123 patients enrolled, 39 (31.7%) developed AKI within seven days after receiving on-pump cardiac surgery. Four patients died in the hospital, resulting in an overall in-hospital mortality of 3.3%, and all deaths occurred in the AKI group. Patients in the AKI group also had longer ICU stays (median difference 3.0 day, 95% CI: 1.0–4.0, P &lt; 0.001) and extubation time (median difference 1.0 days, 95% CI: 0–2.0, P &lt; 0.001) than those in the non-AKI group. Multivariable logistic regression revealed that BMI over 24 kg/m2 (OR: 3.00, 95% CI: 1.24–7.28) and comorbid SLE (OR: 4.73, 95% CI: 1.73–12.93) were independently correlated with postoperative AKI.ConclusionFactors potentially correlated with AKI following on-pump cardiac surgery in patients with connective tissue disease were explored. Clinicians should pay more attention to preoperative evaluation and intraoperative management in patients with risk factors.
Candidate composite biomarker to inform drug treatments for diabetic kidney disease
Authors: Jones Roger D. , Abebe Seyum , Distefano Veronica , Mayer Gert , Poli Irene , Silvestri Claudio , Slanzi Debora 
Published: November 2023

IntroductionCurrent guidelines recommend renin angiotensin system inhibitors (RASi) as key components of treatment of diabetic kidney disease (DKD). Additional options include sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP1a), and mineralocorticoid receptor antagonists (MCRa). The identification of the optimum drug combination for an individual is difficult because of the inter-, and longitudinal intra-individual heterogeneity of response to therapy.ResultsUsing data from a large observational study (PROVALID), we identified a set of parameters that can be combined into a meaningful composite biomarker that appears to be able to identify which of the various treatment options is clinically beneficial for an individual. It uses machine-earning techniques to estimate under what conditions a treatment of RASi plus an additional treatment is different from the treatment with RASi alone. The measure of difference is the annual percent change (ΔeGFR) in the estimated glomerular filtration rate (ΔeGFR). The 1eGFR is estimated for both the RASi-alone treatment and the add-on treatment.DiscussionHigher estimated increase of eGFR for add-on patients compared with RASi-alone patients indicates that prognosis may be improved with the add-on treatment. The personalized biomarker value thus identifies which patients may benefit from the additional treatment.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates
Authors: Zhang Yuwei , Lv FenFen , Su Yan , Zhang Huan , Zhang Baojiang 
Published: November 2023

IntroductionStreptococcus equi subspecies equi (S. equi) is the causative agent of strangles, which is one of the most common and highly contagious respiratory infectious illnesses in horses. Streptococcus equi (S. equi) is a horse-specific pathogen that originated from the closely related zoonotic pathogen Streptococcus equi subspecies zooepidemicus (S. zooepidemicus). Despite decades of research, the movement of genetic material across host-restricted diseases remains a mystery.MethodsThree S. equi donkey isolates (HTP133, HTP232, and HT1112) were recently isolated from a strangles epidemic on donkey farms in China’s Xinjiang Province. In this study, we performed a comprehensive comparative analysis of these isolates using whole genome sequencing and compared them to the published genomic sequences of equine strain S. equi 4047 to uncover evidence of genetic events that shaped the evolution of these donkey S. equi isolates’ genomes.ResultsWhole genome sequencing indicated that both strains were closely related, with comparable gene compositions and a high rate of shared core genomes (1788-2004). Our comparative genomic study indicated that the genome structure is substantially conserved across three donkey strains; however, there are several rearrangements and inversions when compared to the horse isolate S. equi 4047. The virulence factors conveyed by genomic islands and prophages, in particular, played a key role in shaping the pathogenic capacity and genetic diversity of these S. equi strains. Furthermore, we discovered that the HT133 isolate had a strong colonization ability and increased motility; the HT1112 isolates had a significantly higher ability for antimicrobial resistance and biofilm formation, and the HT232 isolate gained pathogenic specialization by acquiring a bacteriophage encoding hyaluronate lyase.DiscussionIn summary, our findings show that genetic exchange across S. equi strains influences the development of the donkey S. equi genome, offering important genetic insights for future epidemiological studies of S. equi infection.
Pediatric neurosurgical-oncology scope and management paradigms in Sub-Saharan Africa: a collaboration among 7 referral hospitals on the subcontinent
Authors: Haizel-Cobbina Joseline , Chotai Silky , Labuschagne Jason , Belete Addisalem , Ashagere Yordanos , Shabani Hamisi K. , Copeland William , Sichizya Kachinga , Ahmad Misbahu Haruna , Nketiah-Boakye Frank , Dewan Michael C. 
Published: November 2023

BackgroundUnderstanding of the epidemiology and biology of pediatric CNS tumors has advanced dramatically over the last decade; however there remains a discrepancy in the understanding of epidemiologic data and clinical capacity between high- and lower-income countries.ObjectiveWe collected and analyzed hospital-level burden and capacity-oriented data from pediatric neurosurgical oncology units at 7 referral hospitals in Sub-Saharan Africa (SSA).MethodsA cross sectional epidemiological survey was conducted using REDCap at the 7 SSA sites, capturing 3-month aggregate data for patients managed over a total of 9 months. Descriptive statistical analyses for the aggregate data were performed.ResultsAcross the neurosurgical spectrum, 15% of neurosurgery outpatient and 16% of neurosurgery operative volume was represented by pediatric neuro-oncology across the 7 study sites. Eighty-six percent and 87% of patients who received surgery underwent preoperative CT scan and/or MRI respectively. Among 312 patients evaluated with a CNS tumor, 211 (68%) underwent surgery. Mean surgery wait time was 26.6 ± 36.3 days after initial presentation at the clinic. The most common tumor location was posterior fossa (n=94, 30%), followed by sellar/suprasellar region (n=56, 18%). Histopathologic analysis was performed for 189 patients (89%). The most common pathologic diagnosis was low grade glioma (n=43, 23%), followed by medulloblastoma (n=37, 20%), and craniopharyngioma (n=31, 17%). Among patients for whom adjuvant therapy was indicated, only 26% received chemotherapy and 15% received radiotherapy.ConclusionThe histopathologic variety of pediatric brain and spinal tumors managed across 7 SSA referral hospitals was similar to published accounts from other parts of the world. About two-thirds of patients received a tumor-directed surgery with significant inter-institutional variability. Less than a third of patients received adjuvant therapy when indicated. Multi-dimensional capacity building efforts in neuro-oncology are necessary to approach parity in the management of children with brain and spinal tumors in SSA.
De-escalated radiotherapy for HER2-overexpressing breast cancer patients with 1-3 positive lymph nodes undergoing anti-HER2 targeted therapy
Authors: Liu Jing , Huang Suning , Bi Zhuofei , Zhang Xiaoxue , He Ziqing , Lan Xiaowen , Tan Yuting , Lin Xiao , Zhou Wenyi , Huang Xiaobo 
Published: November 2023

BackgroundIn the era of anti-HER2 targeted therapy, the potential clinical feasibility of considering HER2-overexpressing breast cancer cases presenting with 1-3 positive axillary lymph nodes as low-risk, and thereby contemplating postoperative radiotherapy reduction, remains an important subject for in-depth examination. The aim of this retrospective study was to evaluate the effectiveness of de-escalated radiotherapy in T1-2N1M0 HER2-overexpressing breast cancer patients receiving anti-HER2 targeted therapy. Specifically, omitting regional lymph node irradiation (RNI) after breast-conserving surgery and only performing whole-breast irradiation or omitting postmastectomy radiation therapy.MethodsA retrospective analysis was conducted on 429 patients with stage T1-2N1M0 primary invasive HER2-overexpressing breast cancer from our center between 2004 and 2018. Patients who received anti-HER2 targeted therapy were divided into an RNI group and a no RNI group to assess the role of RNI. The prognostic role of RNI was investigated via the Kaplan-Meier method and Cox proportional hazards modeling.ResultsThe median follow-up time was 46.8 months (range 7.1–225.8 months). In the anti-HER2 targeted therapy group RNI yielded no significant improvements in invasive disease-free survival (IDFS) (p = 0.940), local-regional recurrence-free survival (p = 0.380), distant metastases-free survival (p = 0.698), or overall survival (p = 0.403). Estrogen receptor (ER) status (hazard ratio [HR] 0.105, 95% confidence interval [CI] 0.023–0.749, p = 0.004) and lymph vascular invasion status (LVI) (HR 5.721, 95% CI 1.586–20.633, p = 0.008) were identified as independent prognostic factors for IDFS, and ER-positive and LVI-negative patients exhibited better prognoses.ConclusionOmitting RNI may be a safe option in T1-2N1 HER2-overexpressing breast cancer patients receiving standardized anti-HER2 targeted therapy; particularly in ER-positive or LVI-negative subgroups.
Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5)
Authors: Bonnavion Remy , Liu Shangmin , Kawase Haruya , Roquid Kenneth Anthony , Offermanns Stefan 
Published: November 2023

Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation. Recently, GPR182, provisionally named ACKR5, was identified as a novel ACKR expressed in microvascular and lymphatic endothelial cells, with functions in hematopoietic stem cell homeostasis. Here, we comprehensively investigated the chemokine binding profile of human and mouse GPR182. Competitive binding assays using flow cytometry revealed that besides CXCL10, CXCL12 and CXCL13, also human and mouse CXCL11, CXCL14 and CCL25, as well as human CCL1, CCL11, CCL19, CCL26, XCL1 and mouse CCL22, CCL24, CCL27 and CCL28 bind with an affinity of less than 100 nM to GPR182. In line with the binding affinity observed in vitro, elevated serum levels of CCL22, CCL24, CCL25, and CCL27 were observed in GPR182-deficient mice, underscoring the role of GPR182 in chemokine scavenging. These data show a broader chemokine binding repertoire of GPR182 than previously reported and they will be important for future work exploring the physiological and pathophysiological roles of GPR182, which we propose to be renamed atypical chemokine receptor 5 (ACKR5).