bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current practices in the veterinary use of antibiotics in poultry laying hens in Friguiagbé (Guinea)
Authors: SOROMOU Lanan Wassy , LENO Pierre Faya , KAMANO Alhassane , SOUARE Mamadou Lamarana , CAMARA Almamy Ousmane Deen , CAMARA Karifa 
Published: January 2024

The use of antibiotic molecules on poultry farms, while justified by their efficacy, must be carried out rationally, as their uncontrolled use modifies the ecology of bacteria and thus contributes to the selection of multi-resistant bacteria. The aim of this study was to carry out a descriptive survey of antibiotic use on laying hen farms in the sub-prefecture of Friguiagbé (Kindia). To achieve this, surveys were carried out among veterinary service managers, poultry farmers and sales outlets. At the end of our work, we identified the existence of two (2) veterinary pharmaceutical supply establishments. Establishments selling veterinary medicines revealed that Tetracycline is the most widely marketed antibiotic family. The most widely used antibiotic molecules are Tetracolivit and Oxytetracycline (26%); Neoxyvital (13%); Alfaceryl and Panteryl (8%); Limoxin (5%); Enrofloxacin, TTS, Colisol and Amoxillin (3%), which are used either for preventive or curative purposes.
Keywords : Antibiotic molecules, poultry farming, laying hens, Guinea
Qualitative Phytochemical Investigation and Acute Oral Toxicity Study on Ethanolic Extract of Curcuma longa Leaves
Authors: Chourasiya Pratima , Gour Rekha , Patel Anant K. 
Published: January 2024

The study focused on evaluating the acute toxicity and phytochemical composition of Curcuma longa leaves using Swiss albino mice. The investigation involved a two-phase acute toxicity test, with doses up to 5000 mg/kg administered orally. The results indicated no toxicity at lower doses, while signs of weakness, salivation, and reduced movement were observed at 1600 mg/kg. Lethal effects were noted at 5000 mg/kg, establishing the LD50 at 2154.06 mg/kg. Phytochemical analysis revealed the presence of alkaloids, flavonoids, glycosides, tannins, and volatile oils in the ethanolic extract. The extract exhibited a 27.37% yield, characterized by a yellowish-orange color and a sticky consistency. This comprehensive investigation sheds light on both the acute toxicity profile and the diverse phytochemical components presents in Curcuma longa leaves.
Keywords: Curcuma longa, Phytoconstituent, Acute oral toxicity, Lokes method.
Tenapanor-A Novel Approach for Management of Hyperphosphatemia in End Stage Renal Disease: A Clinical Study Aggregate Review
Authors: Lobo Leema , Kishore N , Sharma Manjari 
Published: January 2024

The critical importance of phosphate regulation in chronic kidney disease (CKD) has been well understood for decades. But new findings, frequently applicable to routine medical care, continue to evolve. Poor health outcomes, greater morbidity, lowered quality of life, and a higher death rate from cardiovascular disease are all linked to the development of CKD-bone mineral ailment. Increased blood phosphate levels are linked to an increased risk of mortality in hemodialysis patients due to changes in phosphate breakdown and declining renal function as CKD advances.In this setting, according to CKD-mineral bone disease recommendations, it is critical to regulate serum phosphate levels in patients with CKD-mineral bone problem. If dialysis and dietary intervention fail to control blood phosphate levels, the use of phosphate binders is advised. Although phosphate binders are successful in lowering blood phosphate levels by actively binding to dietary phosphate, certain individuals have adverse effects that may restrict their use.These medications also have a significant pill load, which might result in poor treatment compliance. Tenapanor, a novel medication, works by inhibiting the sodium/hydrogen exporter isoform 3 (NHE3), which lowers intestinal phosphate absorption primarily by decreasing passive paracellular phosphate flow. Tenapanor also reduces the expression of the sodium phosphorus 2b transport protein (NaPi2b), which limits active transcellular phosphate absorption compensation. This is considered to be more effective phosphorous absorption regulator and a better target for tailored medication therapy. This clinical study aggregate report explores the currently published studies that have evaluated Tenapanor for the treatment of hyperphosphatemia in end stage renal disease patients on haemodialysis.
Keywords: Tenapanor, phosphate binding agents, hyperphosphatemia, chronic kidney disease, phosphate control, phosphate binders, phosphate absorption, phosphate absorbtion inhibitor.
Encapsulation Methods and Releasing Mechanisms of Encapsulated Active Drug
Authors: N’GUESSAN-GNAMAN Kakwokpo Clémence , TUO-KOUASSI Nakognon Awa , DALLY Ismael , AKA-ANY-GRAH Sandrine , CHOUGOUO KENGNE-NKUITCHOU Rosine Désirée , LIA Arthur José , ANIN Apo Laurette , N’GUESSAN Alain 
Published: January 2024

Substances of plant origin are chemically unstable and easily oxidized by external conditions. However, they have to remain in their bioactive form when they are used in food, pharmaceutical, nutraceutical and cosmetic industries. Encapsulation method is an effective technique that should protect them preventing the degradation of these active substances and thus prevent them from losing their activities.
In this review, the strategies for encapsulating plant substances and their preparation methods including emulsification, atomization, coaxial electrospray system, lyophilization, coacervation, in situ polymerization, melt extrusion, supercritical fluid technology, fluidized bed coating etc. were discussed. The release mechanisms of plant active substances were also presented.
The choice of an appropriate encapsulation technique and wall material depends on the final use of the product and the processing conditions involved. The use of liposomes, ethosomes, phytosomes, emulsions, microspheres, microcapsules, solid lipid nanoparticles including formulations based on plant substances has enhanced their therapeutic effects. With the use of all these encapsulation systems, the formulation is delivered in a targeted manner, giving it an on-site effect, and the bioavailability of the formulation is also improved. With these new drug delivery systems, actives and extracts used in herbal formulations exhibit improved stability, sustained release from the formulation, protection against toxicity, and improved therapeutic efficacy.
Keywords : nanoparticles, bioactive substance, formulation
Ethanolic Stem-Bark Extract of Blighia unijugata Possesses Anti-Hyperglycemic and Anti-Hyperlipidemic Activity in a Streptozotocin-Induced Diabetes Model
Authors: FIADJOE HOPE KORSHIE , Koffuor George Assumeng 
Published: January 2024

Introduction: The global rise in the incidence of diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), and its associated complications have become a public health threat. Besides hyperglycemia, hyperlipidemia has been associated with diabetes due to the defect in insulin secretion and/or action. Medicinal plants are being investigated to discover drug alternatives with better efficacies, lesser adverse effects, and cost-effectiveness. This work investigated the anti-hyperglycemic and anti-hyperlipidemic activity of ethanolic stem bark extract of Blighia unijugata (EBU) in streptozotocin (STZ)-induced diabetic Sprague- Dawley (SD) rats.
Method: T2DM was induced in male SD rats by a single intraperitoneal injection of STZ (50 mg/kg in 0.1 M citrate buffer, pH 4.5) and confirmed 72 hours later. EBU (100 and 200 mg/kg) and glibenclamide (5 mg/kg) were administered orally to the diabetic rats (n = 5) for 28 days. The effect of the treatments on fasting blood glucose (FBG), lipid profile, atherogenic predictor indices, and body weight were assessed.
Results: EBU treatments significantly reduced (p≤0.001) elevated blood glucose, total cholesterol, triglycerides, and Very Low-Density Lipoprotein cholesterol (VLDL-c, p≤0.001) but increased High-Density Lipoprotein cholesterol (HDL, p≤0.05) compared to the diabetic control. Also, all the atherogenic risk predictor indices were significantly reduced (p≤0.001). In addition, EBU treatment mitigated the significant weight loss (p≤0.01) associated with the diabetic state when compared to the normal control.
Conclusion: These findings first report the anti-hyperglycemic, anti-hyperlipidemic, and anti-atherogenic properties of the stem bark of ethanolic extract of Blighia unijugata, and can be further studied and used as an anti-diabetic and anti-hyperlipidemic agent.
Keywords: Blighia unijugata; hyperglycemia; atherogenic index; hyperlipidemia; diabetes
MAPPING OF A THICK SEDIMENTARY COVER FOR MINERAL EXPLORATION AT THE SOUTHERN BENUE TROUGH OF NIGERIA FROM A SYNTHETIC BOUGUER GRAVITY DATA
Authors: APEH Ojima Isaac , TENZER Robert , PHAM Luan Thanh , MOKA Elochukwu Chukwuekezie , ONAH Emmanuel Udochukwu 
Published: January 2024

Mapping of the basement relief in
regions of a high geological importance is key to mineral prospecting.
In this study, we estimate the sediment thickness within the Southern
Benue Trough of Nigeria by using synthetic Bouguer gravity data
alongside 113 logged borehole data to validate the gravimetric inversion
and interpretation.A 3-D gravimetric inversion of the residual gravity
data was carried out to determine the thickness of sedimentation after a
regional-residual gravity separation. Our numerical results (ranging
from 0.8 to 5.5 km) have almost no systematic bias (mean value = 0.045)
when compared with the 113 measured sediment depths obtained from
drilling profiles. The estimated sediment depths closely mimic the known
geological structures and tectonic complexities of the highly rifted
Southern Benue Trough of Nigeria. The synthetic Bouguer gravity map
exhibits a spatial pattern that indicates possible magmatic movements,
which could have led to shallow sediments over and along the Abakaliki
Anticlinorium. This elevated crust (because of an upward magmatic
movement) created crevices, faults, folds, ridges, or troughs that must
have paved way for a thick sedimentary cover that possibly have matured
overtime (because of a high temperature) into important habitats for
mineral resources. We conclude that the very thick sedimentary cover at
the southwestern portion of the study area may have been brought about
by a compaction or compression of tectonic plates thereby generating
adequate heat and pressure for the maturation of several mineral
resources at the Southern Benue Trough of Nigeria.
Keyword: Bouguer gravity maps; gravity inversion; sediment
thickness; Regional-residual gravity separation; mineral exploration
Prospects for Underground Hydrogen Storage in Saline Reservoirs: A Case Study of Sacramento Basin
Authors: Sekar Lokesh Kumar , Galvis H , Okoroafor Esuru 
Published: January 2024

The objective of this work was to understand the suitability and
favorability of saline reservoirs for storing hydrogen and ensuring the
maximum amount of hydrogen would be withdrawn. We used the Sacramento
basin in California to demonstrate the feasibility. We carried out
several numerical simulation studies to understand key factors affecting
the storage and withdrawal of hydrogen. We combined the results from the
numerical modeling to develop a screening and ranking set of criteria
for hydrogen storage in saline reservoirs. We then used the screening
and ranking set of criteria to rank the formations in the Sacramento
basin.
We studied five formations in the Sacramento Basin. The numerical
simulation study showed that to optimize storage and withdrawal of
hydrogen, steeply dipping reservoirs up to 15 degrees, reservoirs with
low pressures, reservoirs with good porosity (above 20%), and
reservoirs with high permeabilities were most favorable for underground
hydrogen storage.
This work applies a novel and comprehensive site screening and selection
criteria for underground hydrogen storage in saline reservoirs. It
builds on a similar work done for carbon dioxide storage and hydrogen
storage in depleted gas fields but it considers additional objective of
needing to withdraw the stored fluid. The case study in Sacramento Basin
can be applied to any other basin.
Znaczenie podaży pieniądza w działalności kredytowej banków komercyjnych
Authors: Stola Emilia 
Published: January 2024

W opracowaniu określono zależności pomiędzy kształtowaniem się wielkości podaży pieniądza, a poziomem udzielonych kredytów przez banki komercyjne w Polsce, oraz dokonano identyfikacji cech wpływających na poziom podaży pieniądza. Na podstawie analizy prostej regresji liniowej i regresji wielorakiej oraz analizy wariancji, potwierdzono statystyczną istotność zależności pomiędzy wzrostem wolumenu udzielonych kredytów, a zwiększeniem się poziomu podaży pieniądza.
Zagospodarowanie nieruchomości ZWRSP i wybrane czynniki ograniczające rozdysponowanie mienia
Authors: Podgórski Bogdan 
Published: January 2024

W opracowaniu przedstawiono stan rozdysponowania nieruchomości Zasobu Własności Rolnej Skarbu Państwa (ZWRSP) oraz podjęto próbę wskazania głównych czynników ograniczających rozdysponowanie nieruchomości. W opracowaniu wykorzystano informacje pochodzące z raportów z działalności Agencji, opracowań wewnętrznych i dostępnej literatury. Zaprezentowane wyniki świadczą, o znacznym zaawansowaniu prywatyzacji mienia, jednak występuje wiele czynników ograniczających proces jego rozdysponowania.
O Almofariz como Ícone da Profissão Farmacêutica: Evolução Histórica e sua importância no Ensino Universitário
Authors: Luís Nicolau José , Conceição Jaime , Rodrigues Isilda , Gonçalves de Freitas Judite 
Published: January 2024

ResumoEsta publicação examina, em perspectiva histórica, a utilização do almofariz, desde os primórdios até à atualidade, evidenciando-se a sua importância no exercício profissional do Farmacêutico e no ensino universitário da Tecnologia Farmacêutica. Atribuiu-se maior relevância ao almofariz de bronze devido ao seu longo período de utilização (desde o século X até ao século XX) e à sua importância artística e simbólica. Em relação à metodologia, recorreu-se à análise documental de diversas fontes, privilegiando-se as fontes primárias. Nos dias de hoje, o almofariz é utilizado pelos farmacêuticos na preparação de medicamentos em Farmácias Comunitárias e Hospitalares, assim como no Ensino Universitário e na Investigação Científica nas Faculdades de Farmácia. Salienta‑se que determinadas operações galénicas são efetuadas recorrendo a este utensílio como, por exemplo, a pulverização de pós em almofariz de porcelana e a mistura de pós em almofariz de vidro. Concluiu-se que o almofariz constitui um ícone por excelência da Profissão Farmacêutica e das Ciências Farmacêuticas. Palavras-chave: Almofariz; História da Farmácia; Ensino. AbstractThis publication examines, in a historical perspective, the use of mortar from the beginning to the present, showing its importance in the professional practice of the Pharmacist and in the higher education of Pharmaceutical Technology. That has been increasing emphasis to the bronze mortar due to its long period of use (from the 10th to the 20th century) and its artistic and symbolic importance. As far as the methodological methods are concerned, a documentary analysis from different sources was performed, favouring primary sources. Nowadays, the mortar is used by pharmacists in the preparation of medicinal products in Community and Hospital Pharmacies, as well as in Higher Education and Scientific Research at the Faculties of Pharmacy. It should be noted that certain galenic operations are carried out using this tool such as powder pulverization in a porcelain mortar and powder mixing in a glass mortar. It was concluded that the mortar constitutes an icon par excellence of the Pharmaceutical Profession and Pharmaceutical Sciences. Keywords: Mortar; History of Pharmacy; Education.
O CONCEITO DE SUJEITO E A PEQUENA VIA DE SANTA TERESINHA DO MENINO JESUS E DA SAGRADA FACE
Authors: Vilarinho Ricardo Francisco Nogueira 
Published: January 2024

Este artigo partiu de uma perspectiva de entrelaçamento teórico e pretendeu refletir sobre o conceito de sujeito descentrado, conforme Mussalim (2006) e Orlandi (2020) e a Teologia de Santa Teresinha do Menino Jesus e da Sagrada Face. Sustentamos a possibilidade de ampliação teórica/metodológica nos pressupostos de Bastos e Palma (2004) e Feyerabend (2011), especificamente na possibilidade de utilização de metodologias pensadas para objetos específicos que podem ser utilizadas em outros objetos diferentes daqueles para as quais foram criadas. Ao final, concluímos que se depreende da Teologia da Pequena Via, proposta pela doutora da Igreja Católica, Santa Teresa de Lisieux, um conceito de sujeito. Palavras-chave: Conceito de sujeito. Entrelaçamento teórico. Santa Teresinha. Filosofia da Linguística.
O CONTEXTO DE SITUAÇÃO NO PODPSI “O QUE ACHAMOS DO FILME 365 DNI”
Authors: Souza Ana Paula Santos de , Pereira Francisca Damiana Formiga 
Published: January 2024

Este artigo objetiva realizar um estudo de análise do Contexto de Situação no podpsi intitulado “O que achamos do filme 365 DNI”. A escolha do material analisado foi feita por dois motivos, primeiro, por fazer parte de um gênero oral e, segundo, por ser o podcast uma ferramenta cada vez mais procurada pelas pessoas para expor suas opiniões e disseminar informações sobre temas vários. A análise foi fundamentada na Linguística Sistêmico-Funcional (LSF), especificamente levando em consideração as ideias desenvolvidas por Halliday e Matthiessen (2014), bem como as atualizações promovidas e apresentadas por Fuzer e Cabral (2014). Os resultados apontam que através das variáveis do Contexto de Situação é possível verificar traços específicos que evidenciam a cena interativa no momento em que ela ocorre, o que possibilita ver a língua em funcionamento e perceber que a construção de sentidos se consolida nesse processo interativo. PALAVRAS-CHAVE: LSF: Contexto de Situação: podpsi.
Dos dados brutos à informação: o papel das técnicas transnumerativas no ensino de Estatística<br>De los datos brutos hacia la información: el papel de las técnicas transnumerativas en la enseñanza de la Estadística
Authors: Cazorla Irene Mauricio , Utsumi Miriam Cardoso , Monteiro Carlos Eduardo Ferreira 
Published: January 2024

Um aspecto importante da aprendizagem de Estatística refere-se à compreensão de sua essência – extrair informação subjacente aos dados –, o que implica no conhecimento da transformação de grandes massas de dados em estatísticas – tabelas, gráficos e medidas resumo - e na interpretação dos seus significados, permitindo a compreensão do fenômeno em estudo. Esse processo tem sido denominado de transnumeração. Neste artigo refletimos sobre aspectos teóricos e possíveis implicações metodológicas da transformação dos dados brutos em estatísticas e estas em informação, e o papel das técnicas transnumerativas, visando auxiliar o ensino dos conceitos de Estatística, na Educação Básica, normatizados pela Base Nacional Comum Curricular. An important aspect of learning statistics refers to the understanding of its essence - extracting information underlying the data -, which implies knowledge about transformation of large amount of data into statistics - tables, graphs, and summary measures - and the interpretation of its meanings, allowing the understanding of phenomenon under study. This process has been called transnumeration. In this article we reflect on theoretical aspects and possible pedagogical implications of transformation of raw data into statistics and these into information, as well as on the role of transnumerative techniques, aiming to support the teaching of statistical concepts in basic education level, standardised by the National Common Curricular Base. Un aspecto importante del aprendizaje de la Estadística se refiere a la comprensión de su esencia -extraer información subyacente a los datos -, lo que implica el conocimiento de la transformación de grandes masas de datos en estadísticas – tablas, gráficos y medidas de resumen - y en la interpretación de sus significados, permitiendo la comprensión del fenómeno en estudio. Este proceso se ha denominado transnumeración. En este artículo reflexionamos sobre los aspectos teóricos y las posibles implicaciones pedagógicas de la transformación de datos brutos en estadísticas y estas en información, y el papel de las técnicas transnumerativas, con el objetivo de ayudar a la enseñanza de los conceptos de estadística, en educación básica, estandarizados por la Base Nacional Común Curricular.
Análisis de la complejidad semiótica y el contexto de las tablas estadísticas en los libros de texto españoles de secundaria<br>Análise da complexidade semiótica e do contexto das tabelas estatísticas nos livros didáticos do ensino secundário espanhol
Authors: Pallauta Jocelyn D. , Arteaga Pedro , Begue Nuria , Gea María Magdalena 
Published: January 2024

El objetivo del presente trabajo es analizar el nivel de complejidad semiótica, junto con los contextos en que se plantean de los propuestos por PISA, en las tablas estadísticas incluidas en una muestra de 18 libros de texto españoles dirigidos a la educación secundaria de tres editoriales diferentes. Para ello se realiza un análisis de contenido del tema de estadística y probabilidad en cada texto seleccionado. Los resultados muestran la complejidad creciente del tipo de tabla estadística al avanzar el curso escolar, siendo la tabla de distribución de una variable la más frecuente, especialmente la que presenta frecuencias ordinarias. El contexto que aparece con mayor fuerza es el personal y se observa también un incremento de tareas sin contexto, especialmente en el último curso de secundaria. This paper aims to analyse the level of semiotic complexity in the statistical tables, together with the contexts in which they arise based on those proposed by PISA, in a sample of 18 Spanish secondary education textbooks from three different publishers. For this, a content analysis of the topic statistics and probability is carried out in each textbook selected. The results show the increasing complexity of statistical tables as the school year progresses, the table of distribution of a variable being the most frequent, especially the one with ordinary frequencies. The context that appears most frequently is the personal, and an increase in tasks without context is observed, especially in the last year of secondary school. O objetivo deste trabalho é analisar o nível de complexidade semiótica das tabelas estadísticas, juntamente com os contextos daquelas propostas pelo PISA, em uma amostra de 18 livros didáticos espanhóis destinados ao ensino secundário, de três editoras diferentes. Para isso, realiza-se em cada texto selecionado uma análise de conteúdo do tema estatística e probabilidade. Os resultados mostram a complexidade crescente do tipo de tabela estatística à medida que o ano letivo avança, sendo a tabela de distribuição de uma variável a mais frequente, especialmente aquela que apresenta frequências comuns. O contexto que se apresenta com maior força é o pessoal, observando-se também um aumento das tarefas sem contexto, especialmente no último ano do ensino médio.