bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic evaluation of anti-obesity drugs for chronic weight management: a systematic review of literature
Authors: Xue Yan , Zou Huimin , Ruan Zhen , Chen Xianwen , Lai Yunfeng , Yao Dongning , Ung Carolina Oi Lam , Hu Hao 
Published: November 2023

IntroductionPharmacological therapy is recommended as a second-line alternative to reverse obesity. Currently, five anti-obesity drugs (AODs) have been approved by the U.S. Food and Drug Administration (FDA) for chronic weight management. The aim of this paper is to investigate the pharmacoeconomic evaluation of AODs through a systematic review with a special focus on methodological considerations.MethodsWe searched the general and specific databases to identify the primary pharmacoeconomic evaluation of AODs.ResultsA total of 18 full-text articles and three conference abstracts were included in this review. Most of the economic assessments were still about Orlistat. And the observations we could make were consistent with the previous systematic review. A few studies were on the combined therapies (i.e. PHEN/TPM ER and NB ER) compared to different comparators, which could hardly lead to a generalized summary of the cost-effectiveness. Most recently, pharmacoeconomic evidence on the newest GLP 1 RA approved for the indication of obesity or obesity with at least one comorbidity emerged gradually. Modelling-based cost-utility analysis is the major type of assessment method. In the modelling studies, a manageable number of the key health states and the state transitions were structured to capture the disease progression. In particular, the principal structure of the decision model adopted in the three studies on the newly approved drug was nearly the same, which enables more in-depth comparisons and generalizations of the findings.ConclusionThis study provided an up-to-date overview of the strengths and areas for improvement in the methodological design of the pharmacoeconomic evaluation of the licensed drugs for chronic weight management. Future modelling evaluations would benefit from a better understanding of the long-term weight loss effects of the current therapeutic options and the weight rebound process after the discontinuation of treatment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022302648, identifier CRD42022302648.
Establishment of a prediction model for the impact of endometrial thickness on the day of embryo transfer on ectopic pregnancy in frozen-thawed embryo transfer cycle
Authors: Li Qiuyuan , Deng Xiyuan , Liu Ahui , Shen Haofei , Zhang Xuehong 
Published: November 2023

ObjectiveThis study aims to investigate the factors affecting the ectopic pregnancy (EP) rate in the frozen-thawed embryo transfer (FET) cycle.MethodsThis study retrospectively analyzed 5606 FET cycles, including 5496 cycles resulting in intrauterine pregnancy and 110 cycles resulting in EP. Smooth curve fitting and piece-wise linear regression were utilized to evaluate a non-linear association between endometrial thickness (EMT) and EP. Multiple logistic regression analysis was used to study the effect of EMT on the embryo transfer (ET) day and other indexes on EP rate after adjusting for confounding factors. A nomographic prediction model was employed to predict EP occurrence. The predictive efficacy of the model was assessed using the area under the receiver operating characteristic (ROC) curve (AUC), utilizing the bootstrap sampling method for internal validation.ResultsAfter accounting for the confounding factors, the segmented linear regression analysis indicated that the EMT inflection point was 9 mm; the EP rate significantly decreased by 28% with each additional millimeter of EMT up to 9 mm (odds ratio (OR) = 0.72; 95% confidence interval (CI), 0.53–0.99; P = 0.0412) while insignificantly decreased when the EMT was greater than 9 mm (OR = 0.91; 95% CI, 0.76–1.08; P = 0.2487). Multivariate logistic regression analysis revealed that after adjusting for confounders, EP risk significantly increased in the number of previous EPs ≥ 1 (OR = 2.29; 95% CI, 1.26–4.16; P = 0.0064) and tubal factor infertility (OR = 3.86; 95% CI, 2.06–7.24; P &lt; 0.0001). Conversely, EP risk was significantly reduced by the increased EMT (OR = 0.84; 95% CI, 0.74–0.96; P = 0.0078) and the blastocyst transfer (OR = 0.45; 95% CI, 0.27–0.76; P = 0.0027). These variables were used as independent variables in a nomogram prediction model, resulting in an AUC of 0.685. The nomination models were internally verified using self-sampling (bootstrap sampling resampling times = 500). This validation yielded an AUC of 0.689, with a sensitivity of 0.6915 and a specificity of 0.5790. The internal validation indicated minimal fluctuations in the AUC, signifying a relatively stable model.ConclusionUndergoing EMT on the day of ET poses a separate EP risk in the FET cycle; to mitigate the EP incidence, the EMT should exceed 9 mm before ET. Furthermore, previous EPs and tubal factor infertility were additional factors independently increasing EP risk. Furthermore, implementing blastocyst transfer demonstrated that EP incidence was significantly reduced. Utilizing a nomogram predicting system enables EP risk evaluation before ET for individual patients, establishing a basis for devising clinical strategies for ET.
A descriptive study on oral hygiene practice and caries increment in children with growth stunting
Authors: Putri Tri Nugrahaeni , Indriyanti Ratna , Setiawan Arlette Suzy 
Published: November 2023

IntroductionStunting is a condition of malnutrition in children from the womb to the early life stage that causes growth failure in the body and brain. Stunting influences the development and integrity of the oral cavity and increases the risk of developing diseases in the oral cavity, such as dental caries. The growth barriers in stunting children and parental knowledge can affect maintaining oral hygiene. This study aims to determine the description of oral hygiene practice and caries increment in children with growth stunting.MethodsThis type of research is a quantitative descriptive with a Secondary Data Analysis approach in the form of examination results for the presence or absence of caries through the ICDAS index and the results of the oral hygiene practice questionnaire on 113 children with growth stunting in Sukajadi district, Bandung.ResultsMost stunting children (60.2%) experienced increased caries rates classified as low, and 70.8% had poor oral hygiene practices. There were 50 children (44.3%) with poor oral hygiene practice with low caries increment, while 18 children (15.9%) had good oral hygiene practice with low caries increment.ConclusionOral hygiene practice is classified as poor, but caries increment is still relatively low in most stunting children in Sukajadi district, Bandung.
Sclerobanding in the treatment of second and third degree hemorrhoidal disease in high risk patients on antiplatelet/anticoagulant therapy without suspension: a pilot study
Authors: Pata Francesco , Bracchitta Luigi M. , Nardo Bruno , Gallo Gaetano , D’Ambrosio Giancarlo , Bracchitta Salvatore 
Published: November 2023

IntroductionAround 20% of population in western countries is under anticoagulant treatment. However, there is paucity of evidence about the treatment of HD in patients under anticoagulant/antiplatelet therapy, although both suspension and continuation in the perioperative period may increase the risk of severe complications. The aim of this pilot study was to confirm the feasibility and safety of sclerobanding (Combined Rubber Band Ligation with 3% Polidocanol Foam Sclerotherapy), an office-based procedure, for the treatment of second-and third-degree HD in patients under anticoagulant/antiplatelet therapy without suspension.Materials and methodsPatients affected by second-third-degree haemorrhoids unresponsive to conservative treatment and under anticoagulant/antiplatelet were enrolled between November 2019 and October 2021. Postoperative complications, readmission, mortality and reintervention during the follow-up were evaluated.ResultsFifty-one patients were recruited, 23 female (45.1%) and 28 male (54.9%), with an average age of 65 years ± 11.4 SD (range 42–90). Twenty-seven patients (52.9%) had II-degree haemorrhoidal disease, and 24 (47.1%) had grade III-degree. The most frequently taken medications were dual antiplatelet therapy (51%) and new oral anticoagulants (NOACs) (21.6%). The mean follow-up was 23 months. No intraoperative complications were recorded. The rate of complications in the first postoperative month was 13.7%, represented by mild complications: 6 cases of moderate to severe pain and 1 case (2%) of thrombosis of a residual haemorrhoidal nodule, all regressing after conservative therapy. No severe complications were reported. Postoperative complications were not statistically significantly associated with the number of nodules treated (1, 2, or 3), the disease grade (2nd vs. 3rd) or the specific anticoagulant/antiplatelet regimen. During follow-up, 2 patients (4%) required a new procedure for recurrent bleeding: one an infrared photocoagulation as outpatient, and another a haemorrhoidectomy after 3 months. No cases of intraoperative or postoperative mortality occurred.ConclusionsSclerobanding is a safe and effective technique in treating intermediate-grade haemorrhoidal disease in patients at high risk on anticoagulant/antiplatelet therapy. Sclerobanding is repeatable, usually does not require anaesthesia, and is cost-effective. Observational multicentre studies with a larger number of patients and controlled clinical trials will be needed to confirm these results.
Dimensional Analysis of Retail Shop Images on Consumer Purchase Intention
Authors: Iswati Heni , Yuwono Yuwono , Meidiyustiani* Rinny 
Published: November 2023

The research aims to determine the effect of retail store image on consumer purchase intention on private label brands. The method used is descriptive verification with a quantitative approach obtained by 217 respondents as a sample. The results of the study show that the regression calculation partially obtains products/merchandise, store atmosphere and customer service and has a significant and significant effect on consumer purchase intentions, but not on price because Private Label Brand (MPL) products do not affect consumer perceptions of buying. Consumers do not mind the price range that has been set by MPL, MPL products are of good quality at a lower price compared to national brands that have the same function.
Keywords: Image Dimensions; Consumer Purchase Intention; Retail; MPL; Product
The Impact of Morale and Work Experience on Hotel Employee Performance
Authors: Faozen Faozen 
Published: November 2023

Human resources are an important aspect of the industry to achieve industrial goals, where industrial goals are carried out if in the industry there are potential and professional human resources, it can provide quality improvement and industrial quality. The objectives of this study include determining the relationship between morale and employee performance, to find out the experience of work on employee performance. This research method uses a total sample of 82 respondents with a saturated sampling method. The results of this research prove that variable morale has a positive and significant impact on employee performance where if morale increases, employee performance will also increase, activity experience affects positively and is important to employee abilities whereas if work experience increases employee performance will also increase. Assessing that morale and good work experience will improve employee performance in hotels.
Keywords: Morale; Work Experience; Performance; Employees; Hotels
The Determinant of Job Performance for Laborers in Manufacturing Companies in Jakarta
Authors: Juwita* Ratna , Wulandari Karina , Arifa Adinda Delia , Hakim Arif Rahman , Rabbani Muhammad Umar , Tambunan Ryan Andreas , Ardiansyah Sahril 
Published: November 2023

This study aims to answer the determinants of job performance based on workplace spirituality, workplace climate, and compensation. Spiritual workplaces are represented by engaging work and a sense of community. By conducting multiple regression tests on respondents from manufacturing companies in Jakarta, it can be concluded that a sense of community and compensation determine the increase in the job performance of workers. The method used is descriptive and verification tests with the classical assumption test. To increase the sense of community, companies can emphasize the formation of workers' sense of belonging to an organization through informal activities such as outings and 'small talks' with employees so that they feel part of the company.
Keywords: Job Performance; Workplace Spirituality; Workplace Climate; Compensation; Engaging Work; Sense of Community
Unraveling the Role of Financial Attitude: A Key Moderator of Financial Literacy in Shaping Financial Behavior
Authors: Sahrian Putra* Muhammad Rafli , Prajawati Maretha Ika 
Published: November 2023

This research aims to examine the influence of financial literacy levels and financial attitudes on financial behavior and the moderating effect of the financial attitude variable. The study employed a questionnaire as a research method distributed to 75 respondents who are the organizers of the Investment Gallery of the Indonesia Stock Exchange at UIN Malang, UM, and Ma Chung University. The analysis technique used Partial Least Square. The research results indicate that financial behavior is positively influenced by the financial literacy level variable, although it is not significant. On the other hand, the financial behavior variable is significantly positively influenced by the financial attitude variable. Moreover, the financial attitude variable, as a moderating variable, has a positive impact on the relationship between the financial literacy level variable and the financial behavior variable.
Keywords: Financial Literacy Level; Financial Attitude; Financial Behavior; Moderating Variable; Partial Least Square
Eco-Brand and Customer-Based Brand Equity: Shaping Consumer Purchase Choices
Authors: Solehati* Aisyah , Pramuditha Panji , Rahma Saura Jeane Aquar 
Published: November 2023

This research aims to determine the influence of eco-branding and brand equity on purchasing decisions for eco-friendly products. This research uses quantitative sampling using the Slovin technique of 100 respondents. The method in this research uses descriptive and verification analysis which is processed using the SPSS V23 program. Judging from the descriptive analysis, it can be seen that eco-branding and brand equity in purchasing decisions are in a good category. Then, through verification analysis, it is stated that there is a partial positive influence of eco-branding and brand equity. With the development of the Eco-brand introduced, the company creates Green Trust in consumers to facilitate product purchasing decisions. Not only consumers but employees are also expected to be involved by representing the company to have a reciprocal impact on society and continue to be responsible for the environment.
Keywords: Eco-Branding; Brand Equity; Purchasing Decisions; Eco-Friendly; Green Trust
Fostering Innovation in MSMEs through Internationalization: The Mediating Roles of Market Orientation and Entrepreneurship in West Java
Authors: Gunawan Arien Arianti , Putri* Mediany Kriseka , Toni Alfita Syifa 
Published: November 2023

This study aims to investigate the effect of internationalization on innovation performance through the mediating factors of market orientation and entrepreneurship in SMEs in emerging markets. The research involved 175 export-ready SMEs in the West Java Province, utilizing a quantitative methodology. The analysis in this study employed Structural Equation Modeling-Partial Least Squares (SEM-PLS) and was processed using the SmartPLS software. Based on the findings of this research, it was determined that internationalization can influence innovation through the mediation of market orientation and entrepreneurship. Therefore, it is recommended for SMEs to recognize their unique value proposition by utilizing the value proposition design method. Additionally, SMEs are advised to maintain strategies that meet consumer needs.
Keywords: MSMEs; Internationalization; Entrepreneurship Orientation; Marketing Orientation; Innovation
The Digital Influence: Exploring the Impact of E-Marketing Techniques on Tiktok Users' Purchase Decisions
Authors: Hidayah* Nurul , Nurrohim Hasa 
Published: November 2023

This research aims to examine the influence of E-Marketing, namely Influencer Marketing, Content Marketing, and User-Generated Content on TikTok users in Daerah Istimewa Yogyakarta regarding their purchase decisions. The criteria for this research include TikTok users aged 18-34 residing in Daerah Istimewa Yogyakarta. The technique used to gather the sample is purposive sampling, and data is collected through an online questionnaire from 100 respondents. The research follows a descriptive analysis with a quantitative approach, and data analysis is conducted using Partial Least Square (PLS) with the data management program Smart PLS 3.0. The results of this study show that influencer marketing has a positive and significant effect on purchase decisions, content marketing similarly has a positive and significant effect on purchase decisions, and user-generated content also positively and significantly influences purchase decisions.Keywords: E-Marketing; Influencer Marketing; Content Marketing; User Generated Content; Purchase Decision; TikTok
PENGGUNAAN TEPUNG KACANG KEDELAI HITAM (Glycine soja L. Merr) SEBAGAI MEDIA ALTERNATIF NUTRIENT AGAR (NA) UNTUK PERTUMBUHAN Staphylococcus aureus
Authors: Apriliani Prity Dwi , Kurniati Iis , Dermawan Asep , Indra Asep Iin Nur 
Published: November 2023

Tepung Kacang Kedelai Hitam (Glycine soja L. Merr) sebagai Media Alternatif Pertumbuhan Staphylococcus aureus: Evaluasi Jumlah Koloni, Konsentrasi Optimum, dan pH. Kacang kedelai hitam memiliki kandungan protein berkisar 35,2% yang dapat digunakan sebagai nutrisi utama untuk pertumbuhan Staphylococcus aureus. Penelitian ini dilakukan bertujuan untuk menentukan apakah tepung kacang kedelai hitam (Glycine soja L. Merr) dapat digunakan sebagai Media Alternatif pengganti Nutrient Agar (NA) untuk pertumbuhan S. aureus dan mengetahui jumlah koloni S. aureus yang tumbuh pada media alternatif serta konsentrasi dan pH optimum yang dapat digunakan untuk pertumbuhan S. aureus. Metode penelitian yang digunakan yaitu kuasi eksperimen yaitu S. aureus ditanam pada media tepung kacang kedelai hitam dengan variasi konsentrasi 2%, 4% dan 6% dengan variasi pH media 6, 7, dan 8. Hasil pengamatan selanjutnya akan dibandingkan dengan hasil pengamatan pada kelompok kontrol yang digunakan yaitu media Nutrient Agar. Berdasarkan uji Two Way ANOVA didapatkan pada konsentrasi 2% (Sig. 0.000) dan 6% (Sig. 0.025) terdapat perbedaan hasil yang signifikan terhadap kontrol, sedangkan pada konsentrasi 4% (Sig. 0.558) tidak ditemukan adanya perbedaan yang signifikan terhadap kontrol. Sehingga dapat disimpulkan bahwa konsentrasi 4% setara dengan kontrol media. Selain itu, pH optimum media untuk pertumbuhan S. aureus terletak pada pH 7 yaitu dapat dilihat pertumbuhan S. aureus yang meningkat dibandingkan dengan media pH 6 dan pH 8.
European Union Strategies Extrapolation for Boosting Students’ Media Literacy in Ukrainian Higher Education
Authors: Bilotserkovets Marina , Fomenko Tatiana , Lushchyk Yuliia 
Published: November 2023

Purpose. The paper deals with the realization of Erasmus+ Jean Monnet Module project that contributes to the strengthening of the role of media literacy among citizens. The aim of the article is to regard practical aspects of media literacy and critical thinking development for higher education (HE) institution’ students in the context of foreign language learning, considering European and Ukrainian experiences.
Methodology of the study involved analysing and generalizing scientific sources to uncover the main issues under investigation; collecting and summarizing valuable points from scholars’ contributions worldwide, intercultural communication observations and descriptions.
Results. The project “European Union (EU) strategies extrapolation for boosting students’ media literacy in Ukrainian HE”, initiated in SNAU with the support of Jean Monnet Foundation within the EU Erasmus+ Program, is targeted at popularizing the main directions of EU policy in the field of media education. While reviewing the European discourse on media literacy it was found that the key strategies in British media education are media authorship, ownership and control, ways of achieving the effect of influence and encoding information of media texts, etc. Finnish media education’s overall goal is enabling students’ analysis of the present and the desired future, and decision making to move towards the desired future. Media education in France is largely determined by semiology, discourse analysis, film analysis, promoting citizens’ participation in the public life, a critical approach to advertising and active resistance to its influence. Austrian and German media education focuses on the control over media with potentially harmful or dangerous content and the development of responsible communication culture. Integrating media literacy into foreign language training is revealed to be essential as it can introduce real-world topics and scenarios relevant to students. The compilers of the training course syllabus considered important European documents on media literacy and language education selecting topics, establishing learning objectives, defining learning outcomes, and setting evaluation criteria.
Conclusions: The results of this study suggest that media literacy skills should be a compulsory subject in all branches of educational faculties and developed throughout life. The training course should be based on advanced innovations and achievements in this field, considering European and Ukrainian experiences.
FAKTOR YANG BERHUBUNGAN DENGAN PIJAT BAYI DI PMB ERNITA,STr.Keb DI PEKANBARU
Authors: Lisviarose  , Komaria Susanti  , Nurhidaya Fitria  
Published: November 2023

Ilmu pengetahuan dan teknologi semakin maju, begitu pula di bidang perkembangan dan pertumbuhan anak. Tradisi cara-cara merawat anak yang diwariskan oleh nenek moyang memiliki banyak manfaat. Salah satu tradisi yang terbukti membantu perkembangan anak yaitu pijat bayi. Pijat bayi merupakan praktik pengasuhan anak secara tradisional yang terbukti khasiatnya. Nenek moyang sudah melakukan pemijatan ketika ada masalah kesehatan seperti gejala rewel, tidak nafsu makan dan perut kembung. Tujuan penelitian ini untuk mengetahui untuk mengetahui Hubungan Pengetahuan, sikap dan perilaku ibu tentang pijat bayi di PMB Ernita,STr.Keb di Pekanbaru. Jenis penelitian ini deskriptif analitik dengan pendekatan cross sectional. Jumlah populasi sebanyak 30 ibu yang mempunyai bayi 0-12 bulan. Teknik pengambilan sampel menggunakan Total sampling. Instrumen penelitian menggunakan kuesioner. Waktu penelitian dilaksanakan pada bulan november 2022. Analisis data data menggunakan analisis univariat dan analisis bivariat. Hasil analisis univariat pengetahuan baik 83,3%, pengetahuan cukup 13,3%, pengetahuan kurang 3,5% sedangkan sikap positif 83,3% dan sikap negatif 16,7% Hasil analisis bivariat dengan menggunakan uji chi square didapatkan bahwa ada hubungan antara pengetahuan dengan pijat bayi dengan nilai p.value 0,016 < 0,005, hubungan sikap ibu tentang pijat bayi dengan nilai p.value 0,414 > 0,005 yang artinya tidak ada hubungan antara sikap dengan pijat bayi. Sehingga dapat disimpulkan adanya ada hubungan antara pengetahuan dengan pijat bayi dan tidak ada hubungan antara sikap dengan pijat bayi. Diharapakan bagi bidan untuk memberikan materi tentang pijat bayi pada saat penyuluhan agar dapat menambah wawasan ibu mengenai pijat bayi dan bisa meningkatkan sikap ibu dalam melakukan pijat bayi