bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of concentrated growth factors for tympanic membrane perforation: a study in guinea pigs
Authors: Hanari Takahiro , Okada Masahiro , Nakata Takahiro , Asoh Sawa , Nishihara Eriko , Teraoka Masato , Hato Naohito 
Published: October 2023

Abstract
Concentrated growth factors (CGF) are complexes comprising a fibrin matrix that incorporates growth factors, plasma, and leukocyte cytokines. Here, we investigated the effectiveness of CGF as a tympanic membrane regeneration therapy in a guinea pig eardrum perforation model. Large tympanic membrane perforations (TMPs) were created in 34 ears of 17 guinea pigs. The ears were divided into the CGF, saline, and control groups. On day 14, considerable differences in perforation closure were observed among the CGF, saline, and control groups. On day 28, the ratio of closure was not considerable between the CGF and saline groups, whereas it was substantially higher in the CGF group than in the control group. Histological observations using hematoxylin and eosin staining showed that the regenerated tympanic membrane was thicker in the CGF group than in the saline group, and the regeneration of the fibrous layer was remarkable in the CGF group than that in the saline group. The results suggest that CGF induces tympanic membrane regeneration and can be used to treat TMPs conservatively.
Multi-aspect and comprehensive atomic insight: the whole process of thermolysis of HMX/Poly- NIMMO-based plastic bonded explosive
Authors: Guo Guoqi , Chen Fang , Li Tianhao , Dong Ling 
Published: October 2023

Abstract
Based on the reactive molecular dynamics, the whole process of thermolysis of HMX/Poly-NIMMO-based PBX was studied in detail at the micro scale, which provided a novel atomic insight into the thermolysis mechanism of HMX/Poly-NIMMO. Further, it was compared with the HMX single substance system to explore the influence of binder on thermolysis of HMX. According to the findings, the activation energy required by pyrolysis of HMX in the mixed system is much less than that required by the pure HMX system at both phases. From the point of view of reaction energy, Poly-NIMMO promoted the thermolysis of HMX. Especially, the mechanism analysis confirmed this point. The nitro and hydroxyl groups detached from Poly-NIMMO will react with HMX, and the generated HNO2 will further accelerate the decomposition process of nitrogen heterocycles. In addition, the number of the final products H2O and H2 in the two-component system increased greatly, but the number of CO2 and N2 molecules had not changed much, and C clusters were formed in the system. The evolution trend of bond number further verified the above analysis. While the maximum cluster number does drop with increasing temperature at first, after a particular temperature threshold is reached, it remains unchanged. In a nutshell, Poly-NIMMO will hasten HMX's thermolysis and reduce the system's stability when subjected to heat.
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice
Authors: Yang Nan-Shi-Yu , Zhong Wen-Jing , Sha Han-Xi , Zhang Chen-Yu , Jin Ling , Duan Jia-Xi , Xiong Jian-Bing , You Zhi-Jian , Zhou Yong , Guan Cha-Xiang 
Published: October 2023

Abstract
Background
NLRP3 inflammasome activation is critical for neuroinflammation in microglia during postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the molecular mechanism by which sevoflurane activates the NLRP3 inflammasome in microglia remains unclear. The cGAS- STING pathway is an evolutionarily conserved inflammatory defense mechanism. The role of the cGAS-STING pathway in sevoflurane-induced NLRP3 inflammasome-dependent neuroinflammation and the underlying mechanisms require further investigation.
Methods
Prolonged anesthesia with sevoflurane was used to induce cognitive dysfunction in mice. The passive avoidance test and Y-maze test were used to assess cognitive function. We then used the cGAS inhibitor RU.521 to investigate whether the cGAS-STING pathway was involved in the NLRP3 inflammasome activation in sevoflurane-induced cognitive dysfunction in mice and neuroinflammation in microglia. To investigate the mechanism of cGAS-STING pathway activation in sevoflurane-treated microglia, we pre-treated microglia with Mdivi-1 (a DRP1 inhibitor), CsA (a mPTP inhibitor) or VBIT-4 (a VDAC inhibitor).
Results
We found that prolonged anesthesia with sevoflurane induced cognitive dysfunction and triggered the neuroinflammation characterized by the activation of NLRP3 inflammasome. Interestingly, the cGAS-STING pathway was activated in the hippocampus of mice receiving sevoflurane. While the blockade of cGAS with RU.521 attenuated cognitive dysfunction and NLRP3 inflammasome activation in mice. In vitro, we found that sevoflurane treatment significantly activated the cGAS-STING pathway in microglia, while RU.521 pre-treatment robustly inhibited sevoflurane-induced NLRP3 inflammasome activation. Mechanistically, sevoflurane-induced mitochondrial fission in microglia and released mitochondrial DNA (mtDNA) into the cytoplasm, which could be abolished with Mdivi-1. Blocking the mtDNA release via the mPTP-VDAC channel attenuated sevoflurane-induced mtDNA cytosolic escape and reduced cGAS-STING pathway activation in microglia, finally inhibiting the NLRP3 inflammasome activation.
Conclusion
In this study, we reported that the cGAS-STING pathway is a novel mechanism of NLRP3 inflammasome activation induced by sevoflurane in microglia during POCD. Therefore, regulating neuroinflammation by targeting the cGAS-STING pathway may provide a novel therapeutic target for POCD.
Rough Statistical Convergence in L-Fuzzy Normed Spaces
Authors: OR Aykut , ÇAKI Ahmet , ÖZCAN Ahmet , Karabacak Gökay 
Published: October 2023

Abstract
The present study introduces the concept of rough convergence and rough statistical convergence of a sequence in L-fuzzy normed spaces. Moreover, it defines the rough statistical limit points and rough statistical cluster points of a sequence in these spaces. It proves some topological properties of a sequences rough statistical limit set in the mentioned spaces. Afterward, it theoretically contributes to these concepts and investigates some of their basic properties. Lastly, the paper inquires about the need for further research.
Graduate Students and the U.S. China Initiative
Authors: Houlette Hilary , Lee Jenny J. , Li Xiaojie 
Published: October 2023

AbstractThe 2018 China Initiative systematically targeted international Chinese scholars as possible spies for China. Previous research demonstrated ways that the China Initiative engaged in racial profiling, resulting in scholars of Chinese descent feeling unwelcomed in U.S. higher education institutions and insecure in their engagement as researchers. Graduate students were not exempt. This study explores the nuanced ways that Chinese graduate students felt discriminated against and racially profiled in comparison to their non-Chinese peers during the height of the U.S. China Initiative. Additionally, this research assesses how those experiences impacted students’ future educational mobility plans. As international Chinese enrollments in the United States are declining, our study seeks to identify the factors that may be contributing to this trend.
Total urinary arsenic concentration from a pediatric patient treated witharsenic trioxide for acute promyelocytic leukemia determined by hydride generation-microwave plasma-atomic emission spectrometry
Authors: Fujihara Junko , Takeshita Haruo , Nishimoto Naoki 
Published: October 2023

Abstract

Although arsenic is well known to be a toxic element, arsenic trioxide (ATO) is an effective pharmaceutical agent for acute promyelocytic leukemia (APL). In this study, total urinary arsenic concentrations from a pediatric patient with APL treated with ATO during induction therapy were determined by hydride generation-microwave plasma-atomic emission spectrometry (HG-MP-AES). The limit of detection and limit of quantification were calculated to be 0.32 and 1.09 ng/mL, respectively. Accuracy and precision were good. The total urinary arsenic concentrations were equivalent to those reported in previous studies. During consolidation therapy, the total urinary arsenic concentrations increased steadily for the first 11 days, and then increased with fluctuations. Our results show that HG-MP-AES is a low-cost, operationally simple, high-sensitivity method suitable for monitoring total urinary arsenic concentrations following ATO treatment. Our method may contribute to determining the dosage and reducing the adverse effects of ATO.
UNDERSTANDING POLITICAL ISSUES THROUGH SOCIAL ACTORS REPRESENTATION:
Authors: Sausina Cut Nina , Indarti Dwi 
Published: September 2023

Critical Discourse Analysis attempts to investigate social, political, historical and environmental issues by analyzing linguistic aspects and resources. This paper aims to examine the strategies used by journalists of tempo.co and CNN Indonesia in delivering the Governor of NTT’s school policy. Two research questions are formulated: (1) How the social actors are described in the news of Governor NTT’s policy publish in tempo.co and cnnindonesia.com. (2) What strategies used by tempo.co and cnnindonesia.com in describing the social actors of Governor NTT’s policy news. The results of the study indicate that the social actors are described in the news of Governor NTT’s policy publish in tempo.co and cnnindonesia.com by clearly mentioned the actors who responsible for the entry school policy. This educates the readers about the policy. Even though the actors are clearly mentioned, there is no tendency to marginalize them, especially Governor of NTT. By covering all person in charge, the readers are presented proportional news. Strategies used by tempo.co and cnnindonesia.com in describing the social actors of Governor NTT’s policy news is only inclusion strategy. Meanwhile, exclusion strategy is not detected in both news by tempo.co and CNN Indonesia.
Association of Serum Adropin Levels with Nutritional Status and Lipid Profile in Patients with Kidney Failure with Replacement Therapy
Authors: Yurtdaş Depboylu Gamze , Acar Tek Nilüfer , Deniz Güneş Burcu , Mengi Çelik Özge , Özata Uyar Gizem , Bayazıt Ayşe Derya , Yaşar Emre , Erten Yasemin 
Published: September 2023

Objective. This study aimed to determine serum adropin levels and to examine the relationship of serum adropin levels with nutritional status and lipid profile in patients with kidney failure with replacement therapy (KFRT).
Methods. The study consisted of 88 subjects, including 30 patients treated with hemodialysis (HD), 29 patients treated with peritoneal dialysis (PD), and 29 patients who had undergone kidney transplantation (TX). The study included assessing anthropometric measurements, handgrip strength, bioelectrical impedance analysis, malnutrition-inflammation score, dietary intake, resting energy expenditure, and biochemical parameters. The patients’ food consumption was recorded for three days. The malnutrition-inflammation score (MIS) was calculated to assess the patients’ nutritional status. Blood samples were collected for serum adropin and other biochemical parameters.
Results. Adropin levels were significantly higher in the TX group when compared to the HD group. Patients with low adropin levels had higher MIS, serum ferritin, and lower low-density lipoprotein-cholesterol (LDL-C) and total cholesterol (total-C) levels. Serum adropin levels were negatively correlated with the MIS and positively correlated with total-C, LDL-C, and HDL-C levels. Multiple linear regression analyses showed that the MIS (β=-0.25 p=0.038) and LDL-C level (β=0.29, p=0.007) were associated with serum adropin.
Conclusions. Adropin may be considered as a new marker of nutritional status and possibly plays a role in the pathophysiological mechanisms and complications of patients with KFRT.
Pengaruh model pembelajaran berbasis proyek terhadap peningkatan kemampuan HOTS di sekolah dasar
Authors: Dewi Ririn Andriani Kumala , A'eni Eni Qurotul , Tanu Wijaya Tommy 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh model pembelajaran berbasis proyek terhadap peningkatan kemampuan higher order thinking skill (HOTS) pada mata pelajaran IPA di kelas IV Sekolah Dasar, di UPTD SDN Sukadadi, Arahan, Indramayu. Metode yang digunakan adalah metode penelitian eksperimen murni, bentuk design adalah Pretest-Posttest Control Group Design. Teknik pengumpulan data tes adalah lembar soal pilihan ganda, lembar soal uraian, dan lembar angket. Teknik analisis data yang digunakan adalah perhitungan uji-t dan uji gain ternormalisasi dengan menggunakan SPSS V.25. Hasil penelitian ini dengan menggunakan uji-t menunjukkan bahwa terdapat pengaruh higher order thinking skill (HOTS) siswa antara kelas kontrol dan kelas eksperimen, adapun nilai sig. 2 (tailed) pada uji-t yaitu 0,027 berdasarkan kriteria pengambilan keputusan 0,027 0,05 sehingga H0 ditolak dan Ha diterima. Hasil penelitian dengan menggunakan uji gain ternormalisasi menunjukkan bahwa terdapat peningkatan kemampuan higher order thinking skill (HOTS) siswa setelah diterapkan model pembelajaran berbasis proyek pada kelas eksperimen yaitu dengan nilai sebesar 0,554 pada kelas eksperimen dan 0,256 pada kelas kontrol.
Simulated slidequakes: Insights from DEM simulations into the high-frequency seismic signal generated by geophysical granular flows
Authors: Arran Matthew , Mangeney A , Rosny J De , Toussaint R 
Published: September 2023

Geophysical granular flows generate seismic signals known as
‘slidequakes’ or ‘landquakes’, with low-frequency components whose
generation by mean forces is widely used to infer hazard-relevant flow
properties. Many more such properties could be inferred by understanding
the fluctuating forces that generate slidequakes’ higher frequency
components and, to do so, Arran et al.
(2021, https://doi.org/10.1029/2021JF006172) (A21) compared the
predictions of pre-existing physical models to the forces exerted by
laboratory-scale flows. However, A21 was unable to establish whether the
laboratory flows exhibited basal slip, and the conditions for applying
its results are therefore unclear. Here, we describe discrete-element
simulations that examined the fluctuating forces exerted by steady,
downslope-periodic granular flows on fixed, rough bases that prevented
basal slip. We show that, in its absence, A21’s results do not hold:
simulated basal forces’ power spectra have high-frequency components
more accurately predicted using mean shear rates than using
depth-averaged flow velocities, and can have intermediate-frequency
components which we relate to chains of prolonged inter-particle
contacts. We develop a ‘minimal model’, which uses a flow’s collisional
properties to even more accurately predict the high-frequency
components, and empirically parametrize this model in terms of mean flow
properties. Finally, we demonstrate that the bulk inertial number
determines not only the magnitude ratio of rapidly fluctuating and mean
forces on a unit basal area, consistent with A21, but also the relative
magnitudes of the high and intermediate-frequency force components.

Plain Language Summary

Any geophysical granular flow-such as a landslide, rockfall, or debris
flow-exerts fluctuating forces that cause the ground to vibrate, in a
‘slidequake’ that can provide useful information about the flow. Here,
we examine simulated slidequakes: computer models of the individual
particles within idealized flows, the collisions between them, and the
rapidly fluctuating forces they exert on the flow’s base. By recording
particle and collision properties throughout the flow, we examine
pre-existing models for the fluctuating forces; develop, test, and
simplify a new model; and relate ratios between forces to an ‘inertial
number’ that characterizes different flows. Our results differ from
those of laboratory experiments that previously investigated
slidequakes, but the two sets of results can be combined to provide
information about real geophysical flows.
Current screening and diagnostic approaches of retinoblastoma in limited setting
Authors: Utomo Nunki Puspita , Kristiani Devie , Mulatsih Sri , Pradana Pande Komang Wahyu 
Published: October 2023

Abstract
As the most common intraocular malignancy in children, retinoblastoma poses a vision, globe, and life-threatening risk and hence requires thorough evaluation and surveillance. While the disease is one of the most curable malignancies in established countries, children of lower-middle-income countries are not so fortunate, especially those with familial history of retinoblastoma. The delay of diagnosis proposes a grave prognosis, thus screening is a must. This study aimed to review the literature on various screening programs and applications described for the early detection of retinoblastoma, especially in a setting where genetic examination performance is limited. A literature search across PubMed®, ProQuest, and EbscoHost (MEDLINE Full text) with the topic of current methods and programs of retinoblastoma screening in neonates, infants, and children were carried out denoting various guideline and recommendations but the implementation is not uniform. Examination under anesthesia and red-reflex tests are among the most frequently conducted but the practices vastly vary especially in a place with low resources. Recent updates in mobile phone freeware should be rigorously upgraded due to its current inadequate sensitivity and specificity in detecting retinoblastoma but pose a promising future for retinoblastoma screening and diagnosis, especially in lower-middle-income countries.
Lear's Daughters? Unenumerated Fundamental Rights and the Constitution
Authors: Halper Thomas 
Published: September 2023

Abstract
How to determine whether fundamental unenumerated constitutional rights exist, and if so, what they are? The questions are of obvious enormous importance—witness the current controversy over abortion—and yet courts have generally been content to address the issues superficially, sometimes, cavalierly. Their treatment of the most common rationale, an historical/traditional consensus, exemplifies this shallow approach. The underdeveloped character of the argumentation on this topic stubbornly remains one of the most glaring shortfalls of modern constitutional law.
Economic Diplomacy in the Caribbean
Authors: Dookeran Winston 
Published: September 2023

Abstract
Caribbean economic diplomacy is at a crossroad, not knowing where and how to turn. This paper opens an intense discourse on the issues facing the Caribbean economy – the nexus between integration and convergence, the stress and resilience of its economic institutions, as well as the dilemma of leaders in the practice of economic diplomacy. The paper also examines the old and new challenges of global cooperation and the framework of power and geopolitics in the conduct of economic diplomacy in the Caribbean. As the frontiers of Caribbean diplomacy shift, its unique and diverse landscape makes the region an enigma with unfolding foreign policy options on a fragile map of the many Caribbeans in one economic space.
Effects of Six-Week Pre-Season Complex Contrast Training Intervention on Male Soccer Players’ Athletic Performance
Authors: Kumar Gopal , Pandey Vivek , Ramirez-Campillo Rodrigo , Thapa Rohit K. 
Published: October 2023

Abstract

Introduction.
This study aimed to investigate the effects of a six-week complex contrast training (CCT) intervention on the athletic performance of highly-trained amateur male soccer players during the pre-season period.

Material and Methods.
Participants aged 21.3 were randomized to CCT (n = 7) or active (i.e. standard soccer training) control (CG; n = 9) groups. Athletic performance was assessed using the 30 m linear sprint test time, standing long jump distance (SLJ), countermovement jump (CMJ) height, and unilateral right-left knee flexion and extension isokinetic maximal strength tests. The experimental group replaced part of the standard soccer training schedule with three CCT sessions per week for six weeks. A two (pre-post intervention) by two (CCT, CG) mixed ANOVA was used to analyze the exercise-specific effects. In addition, between-group comparisons at post-test were conducted with baseline scores as covariate. Within group changes were analyzed using paired t-test.

Results.
Significant group-by-time interaction effects were found for all dependent variables (p < 0.001 – 0.004). Post-hoc tests using paired t-test revealed significant improvements in all dependent variables in CCT (all p ≤ 0.001; effect size (g) = 0.29 – 0.96; %Δ = 4.5 – 14.7), but not in CG (p = 0.174 – 0.633; g = 0.03 – 0.20; %Δ = 0.4 – 2.6). Further, Bonferroni adjusted post-hoc analysis using baseline scores as a covariate showed post-test differences in favor of CCT compared to CG for all variables.

Conclusions.
CCT is recommended as an effective training strategy during the pre-season to improve athletic performance among highly-trained amateur male soccer players.
Second-Order Work Criterion in the Stability Analysis of an Earth Dam Subjected to Seepage
Authors: Sternik Krzysztof 
Published: September 2023

Abstract
Failure may take different forms: reaching the Mohr–Coulomb limit stress condition is accompanied by yielding, strain localisation may occur in shear, compaction or dilatant bands, arbitrary large strain and loss of strength may be accompanied by a field of chaotic displacements of soil particles. Failure is also related to material instability. It takes place when there is a loss of uniqueness of constitutive relationships. It has been found that instability domains exist strictly inside the Mohr–Coulomb failure surface. Material instability can be detected by local Hill's criterion, that is the second-order work at a point. Results of a coupled hydro-mechanical finite element analysis of an ‘earth dam – subgrade’ system at changing hydraulic boundary conditions have been presented in the article. Normalised values of the second-order work and factor of safety values by the shear strength reduction procedure for corresponding stages of the analysis were calculated. It has been shown that the value of the safety factor corresponds to the values of the second-order work. The analysis results show that a decrease in the value of the safety factor is accompanied by a decrease in the value of the second-order work until negative values occur at some points.
APPLICATION OF BUSINESS INTELLIGENCE IN THE CRIMINAL ACTION OF CURANMOR (CASE STUDY OF THE LEGAL AREA OF DENPASAR POLICE)
Authors: Gilang Ramadhan Rizki Aditiya , Sasmita Gusti Made Arya , Mandenni Ni Made Ika Marini 
Published: September 2023

Kejahatan merupakan suatu bentuk tindakan yang dapat merugikan orang lain, salah satunya tindak kejahatan pencurian kendaraan bermotor. Terdapat banyak faktor yang menyebabkan seseorang melakukan tindakan pencurian kendaraan bermotor, salah satunya adalah kurangnya pengaman didalam kendaraan bermotor yang menyebabkan mudahkan pencuri melakukan tindakan curanmor. Provinsi Bali mengalami peningkatan tingkat curnamor setiap tahunnya. Berdasarkan hal tersebut polisi daerah Provinsi Bali membutuhkan strategi yang tepat didalam memantau perkembangan tingkat curanmor beserta cara agar menanggulanginya. Penelitian ini bertujuan untuk membangun dashboard business intelligence untuk memudahkan didalam memonitoring tingkat kejahatan curanmor khususnya di Provinsi Bali sekaligus menggantikan pemakaian kertas menjadi media database. Proses didalam pembuatan dashboard menggunakan beberapa metode diantaranya ETL (Extraction, Transformation, Loading) yang nantinya hasil pengolahan data akan disimpan kedalam database menggunakan tools MySQL, dan OLAP (Online Analytical Processing) yang nantinya menghasilkan visualisasi dalam bentuk dashboard menggunakan tools Microsoft Power BI dan adanya penambahan peramalan menggunakan metode regresi linier. Visualisasi yang dihasilkan didalam penelitian ini akan berupa bar chart, line chart, dan geographic information system atau GIS.