bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covalent Coupling Assisted Hydrophilic Perovskite Spheres for Ratiometric Fluorescent Visual Multichannel Immunoassay
Authors: Han Yaqin , An Jia , Yuan Mengdi , Fang Junan , Zhang Jiajing , Liang Lanju , Liu Yufei 
Published: December 2023

AbstractQuantitative fluorescence immunoassay is essential for the construction of biosensing mechanisms and the quantification of trace markers. But the interference problems caused by low fluorescence efficiency and broad fluorescence spectrum of fluorescent probes have hindered the continued development of ratiometric fluorescence sensing in biosensing. Perovskite materials, with ultra‐high color purity (FWHM < 30 nm) and photoluminescence quantum yield (PLQY) (close to 100%), are expected to be next‐generation fluorescent probes. However, poor water stability and biocompatibility are still non‐negligible in biosensor applications. In this work, hyperstatic perovskite fluorescent microspheres prepared by swelling‐shrinking method can be used as ratiometric fluorescence signals and biological immunoassay platforms. Meanwhile, inspired by p‐aminophenol (AP) controlled synthesis and the catalytic reaction of 4‐aminophenol phosphate (APP) triggered by alkaline phosphatase (ALP), a strategy to prepare fluorescent nanoparticles as fluorescence signals for ALP detection is proposed. Most importantly, it is proposed for the first time to combine this enzymatic fluorescence with perovskite materials using covalent linkage to create a novel cascade immunoassay and use it for quantitative and visualization determination of hepatitis B surface antigen (HBsAg) for application verification. These results indicate the biosensing potential of perovskite materials and provide a pathway for high sensitivity enzyme detection and enzyme triggered immune detection.
Ultra‐Sleek High Entropy Alloy Tights: Realizing Superior Cyclability for Anode‐Free Battery
Authors: Wang Jun , Wang Yi , Lu Xiaomeng , Qian Ji , Yang Chao , Manke Ingo , Song Haojie , Liao Jiaxuan , Wang Sizhe , Chen Renjie 
Published: December 2023

AbstractThe development of Li‐free anodes to inhibit Li dendrite formation and provide high energy density Li batteries is highly applauded. However, the lithiophobic interphase and heterogeneous Li deposition hindered the practical application. In this work, a 20 nm ultra‐sleek high entropy alloy (HEA, NiCdCuInZn) tights loaded with HEA nanoparticles are developed by a thermodynamically driven phase transition method on the carbon fiber (HEA/C). Multiple Li+ transport paths and abundant active sites are enabled by the cocktail effect of different constituent elements in HEA. These active sites with gradient absorption energies (−3.18 to −2.03 eV) facilitate selective binding, providing a low barrier for homogeneous Li nucleation. Simultaneously, multiple transport paths promote Li diffusion behavior with uniform Li deposition. Thus, the HEA/C achieves high reversibility of Li plating/stripping processes over 2000 cycles with a coulombic efficiency of 99.6% at 5 mA cm−2/1 mAh cm−2 in asymmetric cells, as well as over 7200 h at 60 mA cm−2/60 mAh cm−2 in symmetric cells. Moreover, the anode‐free full cell with the HEA/C host has an average coulombic efficiency of 99.5% at 1 C after 160 cycles. This advanced HEA structure design shows a favorable potential application for anode‐free Li metal batteries.
A CTL‐Inspired Killing System Using Ultralow‐Dose Chemical‐Drugs to Induce a Pyroptosis‐Mediated Antitumor Immune Function
Authors: Yin Hao , Xie Congying , Zuo Zhigui , Xie Danli , Wang Qinyang 
Published: December 2023

AbstractA Cytotoxic T lymphocyte‐inspired system capable of using ultralow‐dose chemical drugs to manipulate cell death is needed to investigate the antitumor immunotherapy. Recent studies reveal pyroptosis promotes antitumor immune function. However, high‐dose chemotherapy leads to cytokine release syndrome by pyroptosis. Therefore, pyroptosis‐inducing ultralow‐dose chemotherapy is potential in preclinical and clinical research, but its efficacy, safety, and the antitumor immune responses are not clear. Here, a near‐infrared light controllable killing system (BIK system) is established by which ultralow‐dose doxorubicin can be spatiotemporally transported to tumor cells and mediate efficient pyroptosis. This BIK system reduces total drug consumption to less than one‐thirtieth the common dose in vitro. Moreover, this BIK system exhibited good tumor targeting and tumor penetration. This system is applied for pyroptosis‐induced antitumor therapies, which shows less than ≈25 µg kg−1 doxorubicin is sufficient for tumor regression with negligible injuries to major organs. The antitumor immune function are proven to correlate with the impressive efficacy of pyroptosis‐inducing ultralow‐dose chemotherapy. This study provides new insights into the design of nanoassisted systems for activating the antitumor immunity by microstimulation; the application of the BIK system suggests that ultralow‐dose chemotherapy is sufficient for inducing a robust pyroptosis‐mediated antitumor immunity.
On‐Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines
Authors: Landers Fabian C. , Gantenbein Valentin , Hertle Lukas , Veciana Andrea , Llacer‐Wintle Joaquin , Chen Xiang‐Zhong , Ye Hao , Franco Carlos , Puigmartí‐Luis Josep , Kim Minsoo , Nelson Bradley J. , Pané Salvador 
Published: December 2023

AbstractMagnetic microrobots have been developed for navigating microscale environments by means of remote magnetic fields. However, limited propulsion speeds at small scales remain an issue in the maneuverability of these devices as magnetic force and torque are proportional to their magnetic volume. Here, a microrobotic superstructure is proposed, which, as analogous to a supramolecular system, consists of two or more microrobotic units that are interconnected and organized through a physical (transient) component (a polymeric frame or a thread). The superstructures consist of microfabricated magnetic helical micromachines interlocked by a magnetic gelatin nanocomposite containing iron oxide nanoparticles (IONPs). While the microhelices enable the motion of the superstructure, the IONPs serve as heating transducers for dissolving the gelatin chassis via magnetic hyperthermia. In a practical demonstration, the superstructure's motion with a gradient magnetic field in a large channel, the disassembly of the superstructure and release of the helical micromachines by a high‐frequency alternating magnetic field, and the corkscrew locomotion of the released helices through a small channel via a rotating magnetic field, is showcased. This adaptable microrobotic superstructure reacts to different magnetic inputs, which can be used to perform complex delivery procedures within intricate regions of the human body.
Nonepitaxial Wafer‐Scale Single‐Crystal 2D Materials on Insulators
Authors: Li Junzhu , Yuan Yue , Lanza Mario , Abate Iwnetim , Tian Bo , Zhang Xixiang 
Published: December 2023

AbstractNext‐generation nanodevices require 2D material synthesis on insulating substrates. However, growing high‐quality 2D‐layered materials, such as hexagonal boron nitride (hBN) and graphene, on insulators is challenging owing to the lack of suitable metal catalysts, imperfect lattice matching with substrates, and other factors. Therefore, developing a generally applicable approach for realizing high‐quality 2D layers on insulators remains crucial, despite numerous strategies being explored. Herein, a universal strategy is introduced for the nonepitaxial synthesis of wafer‐scale single‐crystal 2D materials on arbitrary insulating substrates. The metal foil in a nonadhered metal–insulator substrate system is almost melted by a brief high‐temperature treatment, thereby pressing the as‐grown 2D layers to well attach onto the insulators. High‐quality, large‐area, single‐crystal, monolayer hBN and graphene films are synthesized on various insulating substrates. This strategy provides new pathways for synthesizing various 2D materials on arbitrary insulators and offers a universal epitaxial platform for future single‐crystal film production.
Engineering Atomically Dispersed Cu–N1S2 Sites via Chemical Vapor Deposition to Boost Enzyme‐Like Activity for Efficient Tumor Therapy
Authors: Xu Bolong , Li Shanshan , Han Along , Zhou You , Sun Mengxue , Yang Haokun , Zheng Lirong , Shi Rui , Liu Huiyu 
Published: December 2023

AbstractSingle‐atom nanozymes (SAzymes), with well‐defined and uniform atomic structures, are an emerging type of natural enzyme mimics. Currently, it is important but challenging to rationally design high‐performance SAzymes and deeply reveal the interaction mechanism between SAzymes and substrate molecules. Herein, this work reports the controllable fabrication of a unique Cu−N1S2‐centred SAzyme (Cu‐N/S‐C) via a chemical vapor deposition‐based sulfur‐engineering strategy. Benefiting from the optimized geometric and electronic structures of single‐atom sites, Cu‐N/S‐C SAzyme shows boosted enzyme‐like activity, especially in catalase‐like activity, with a 13.8‐fold increase in the affinity to hydrogen peroxide (H2O2) substrate and a 65.2‐fold increase in the catalytic efficiency when compared to Cu‐N‐C SAzyme with Cu−N3 sites. Further theoretical studies reveal that the increased electron density around single‐atom Cu is achieved through electron redistribution, and the efficient charge transfer between Cu‐N/S‐C and H2O2 is demonstrated to be more beneficial for the adsorption and activation of H2O2. The as‐designed Cu‐N/S‐C SAzyme possesses an excellent antitumor effect through the synergy of catalytic therapy and oxygen‐dependent phototherapy. This study provides a strategy for the rational design of SAzymes, and the proposed electron redistribution and charge transfer mechanism will help to understand the coordination environment effect of single‐atom metal sites on H2O2‐mediated enzyme‐like catalytic processes.
Magnetic Aggregation‐Induced Bone‐Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic–Angiogenic Coupling for Osteoporotic Bone Repair
Authors: Guan Haitao , Wang Wei , Jiang Zichao , Zhang Boyu , Ye Zhipeng , Zheng Judun , Chen Wei , Liao Yuhui , Zhang Yingze 
Published: December 2023

AbstractOsteoporosis, characterized by an imbalance in bone homeostasis, is a global health concern. Bone defects are difficult to heal in patients with osteoporosis. Classical drug treatments for osteoporotic bone defects have unsatisfactory efficacy owing to side effects and imprecise delivery problems. In this study, a magnetic aggregation‐induced bone‐targeting poly(lactic‐co‐glycolic acid, PLGA)‐based nanocarrier (ZOL‐PLGA@Yoda1/SPIO) is synthesized to realize dual‐targeted delivery and precise Piezo1‐activated therapy for osteoporotic bone defects. Piezo1 is an important mechanotransducer that plays a key role in regulating bone homeostasis. To achieve dual‐targeting properties, ZOL‐PLGA@Yoda1/SPIO is fabricated using zoledronate (ZOL)‐decorated PLGA, superparamagnetic iron oxide (SPIO), and Piezo1‐activated molecule Yoda1 via the emulsion solvent diffusion method. Bone‐targeting molecular mediation and magnetic aggregation‐induced properties can jointly and effectively achieve precise delivery to localized bone defects. Moreover, Yoda1 loading enables targeted and efficient mimicking of mechanical signals and activation of Piezo1. Experiments in vivo and in vitro demonstrate that ZOL‐PLGA@Yoda1/SPIO can activate Piezo1 in bone defect areas of osteoporotic mice, improve osteogenesis through YAP/β‐catenin signaling axis, promote a well‐coordinated osteogenesis–angiogenesis coupling, and significantly accelerate bone reconstruction within the defects without noticeable side effects. Overall, this novel dual‐targeting nanocarrier provides a potentially effective strategy for the clinical treatment of osteoporotic bone defects.
Ti3C2Tx MXene Polyester Fiber Mesh Composite as Broadband Terahertz Absorber
Authors: Li Yanke , Song Zihang , Lin Shangjun , Zhang Longhui , Jiang Mingzhu , Zeng Lizhen , Hu Fangrong 
Published: December 2023

AbstractTerahertz (THz) absorbing materials have significant potential applications in THz radar, telecommunications, stealth, detection, and other fields. However, the design and fabrication of THz broadband absorber is still a challenge. In this work, the Ti3C2Tx MXene polyester fiber mesh (MPFM) composite is successfully synthesized using dip‐coating method. By optimizing the fabrication and structures, this study realizes a remarkable absorption rate of over 90% in a wide frequency range of 0.7−2.5 THz. Additionally, Ti3C2Tx loading in the composite is only 0.8 mg, accounting for 6.7 wt.% of the MPFM. The THz absorption capacity of MPFM is minimally affected by the multilayer PFM stacking method and the loading amount of Ti3C2Tx, but rather by the PFM aperture size and stack thickness. The proposed method paves the way for developing THz broadband absorbers using lightweight flexible composite.
A Versatile Photocrosslinkable Silicone Composite for 3D Printing Applications
Authors: Alioglu Mecit Altan , Yilmaz Yasar Ozer , Gerhard Ethan Michael , Pal Vaibhav , Gupta Deepak , Rizvi Syed Hasan Askari , Ozbolat Ibrahim T. 
Published: December 2023

AbstractEmbedded printing has emerged as a valuable tool for fabricating complex structures and microfluidic devices. Currently, an ample of amount of research is going on to develop new materials to advance its capabilities and increase its potential applications. Here, a novel, transparent, printable, photocrosslinkable, and tuneable silicone composite is demonstrated that can be utilized as a support bath or an extrudable ink for embedded printing. Its properties can be tuned to achieve ideal rheological properties, such as optimal self‐recovery and yield stress, for use in 3D printing. When used as a support bath, it facilitated the generation microfluidic devices with circular channels of diameter up to 30 µm. To demonstrate its utility, flow focusing microfluidic devices are fabricated for generation of Janus microrods, which can be easily modified for multitude of applications. When used as an extrudable ink, 3D printing of complex‐shaped constructs are achieved with integrated electronics, which greatly extends its potential applications toward soft robotics. Further, its biocompatibility is tested with multiple cell types to validate its applicability for tissue engineering. Altogether, this material offers a myriad of potential applications (i.e., soft robotics, microfluidics, bioprinting) by providing a facile approach to develop complicated 3D structures and interconnected channels.
Unveiling the Crucial Impact of Defects in the Hole Transport Layer on the Efficiency of Phosphorescent Organic Light‐Emitting Diodes
Authors: Yang Kwangmo , Nam Sungho , Kim Joonghyuk , Kim Ji Whan , Lee Jaesang 
Published: December 2023

AbstractThe ongoing challenge in advancing organic light‐emitting diodes (OLEDs) is to mitigate performance degradation during operation, caused by the dissociation of molecular components and the ensuing defect formation. While defects can emerge throughout OLEDs with diverse detrimental effects, prior research has predominantly focused on those within the emission layer (EML), leaving other device areas unexplored. In this work, a previously overlooked, yet profound impact of defects in the hole transport layer (HTL) on charge and exciton dynamics in a phosphorescent OLED (PHOLED) is investigated. HTL defects confine and impede the injection of free holes into the EML, requiring an increased supply of electrons to maintain constant current in the device. Consequently, excitons become concentrated at the HTL/EML interface, leading to enhanced bimolecular annihilations and an 8% reduction in device efficiency. Furthermore, when HTL defects are within 8 nm from the interface, they can directly quench excitons, resulting in a substantial decrease in device efficiency by up to 76%. This defect‐induced exciton quenching occurs through both Dexter and Förster energy transfer, each with distinct distance dependence. The findings emphasize the necessity of preventing defect formation, particularly in proximity to the HTL/EML interface, to minimize efficiency degradation for PHOLEDs.
Color Tunable Phosphorescent Neutral Manganese(II) Complexes Through Steric Hindrance Driven Bond Angle Distortion
Authors: She Pengfei , Zheng Zhong , Qin Yanyan , Li Feiyang , Zheng Xiaokang , Zhang Dongdong , Xie Zhiyuan , Duan Lian , Wong Wai‐Yeung 
Published: December 2023

AbstractPhosphorescent manganese(II) complexes with high photoluminescence quantum yields (PLQYs) and low cost exhibit great potential in organic light‐emitting diodes (OLEDs), information security, and X‐ray imaging. However, it is still a challenge to tune their emission colors. Herein, an effective strategy for engineering the phosphorescence colors of tetrahedral Mn(II) complexes through steric hindrance‐driven bond angle distortion is proposed. Modulating the steric hindrance between phosphine and benzofuran and varying the O─Mn─O bond angles allows these Mn(II) complexes to emit from 498 to 548 nm. Interestingly, these achiral single crystals of Mn(II) complexes exhibit significant circularly polarized luminescence signals due to symmetry breaking. Furthermore, high‐performance green OLEDs are achieved by using these Mn(II) complexes as dopants, providing a record‐high external quantum efficiency of 15.7%. These super‐duper results greatly inspire the development of multi‐color Mn(II) complexes and low‐cost Mn‐based devices.
Human Pluripotent Stem Cells Derived Endothelial Cells Repair Choroidal Ischemia
Authors: Li Mengda , Wang Peiliang , Huo Si Tong , Qiu Hui , Li Chendi , Lin Siyong , Guo Libin , Ji Yicong , Zhu Yonglin , Liu Jinyang , Guo Jianying , Na Jie , Hu Yuntao 
Published: December 2023

AbstractChoroidal atrophy is a common fundus pathological change closely related to the development of age‐related macular degeneration (AMD), retinitis pigmentosa, and pathological myopia. Studies suggest that choroidal endothelial cells (CECs) that form the choriocapillaris vessels are the first cells lost in choroidal atrophy. It is found that endothelial cells derived from human pluripotent stem cells (hPSC‐ECs) through the MESP1+ mesodermal progenitor stage express CECs‐specific markers and can integrate into choriocapillaris. Single‐cell RNA‐seq (scRNA‐seq) studies show that hPSC‐ECs upregulate angiogenesis and immune‐modulatory and neural protective genes after interacting with ex vivo ischemic choroid. In a rat model of choroidal ischemia (CI), transplantation of hPSC‐ECs into the suprachoroidal space increases choroid thickness and vasculature density. Close‐up examination shows that engrafted hPSC‐ECs integrate with all layers of rat choroidal vessels and last 90 days. Remarkably, EC transplantation improves the visual function of CI rats. The work demonstrates that hPSC‐ECs can be used to repair choroidal ischemia in the animal model, which may lead to a new therapy to alleviate choroidal atrophy implicated in dry AMD, pathological myopia, and other ocular diseases.
Natural Acceptor of Coumarin‐Isomerized Red‐Emissive BioAIEgen for Monitoring Cu2+ Concentration in Live Cells via FLIM
Authors: Cai Xu‐Min , Li Shouji , Wang Wen‐Jin , Lin Yuting , Zhong Weiren , Yang Yalan , Kühn Fritz E. , Li Ying , Zhao Zheng , Tang Ben Zhong 
Published: December 2023

AbstractArtificial aggregation‐induced emission luminogens (AIEgens) have flourished in bio‐applications with the development of synthetic chemistry, which however are plagued by issues like singularity in structures and non‐renewability. The unique structures and renewability of biomass moieties can compensate for these drawbacks, but their properties are hard to design and regulate due to their confined structures. Therefore, it appears to be a reasonable approach to derive AIEgens from abundant biomass (BioAIEgens), integrating the bilateral advantages of both synthetic and natural AIEgens. In this work, the blue‐violet emissive coumarin with its lactone structure serving as a rare natural acceptor, is utilized to construct donor‐π‐acceptor typed BioAIE isomers incorporating the propeller‐like and electron‐donating triphenylamine (TPA) unit. The results show that Cm‐p‐TPA undergoes charge transfer with its keto form, emitting red light at 600 nm, which can be applied to monitor Cu2+ concentration during mitophagy using fluorescence lifetime imaging microscopy because of the excellent biocompatibility, photostability, and specific recognition to Cu2+. This work not only demonstrates the feasibility of utilizing positional isomerization to modulate excited‐state evolutions and resultant optical properties, but also provides evidence for the rationality of constructing biologically‐active BioAIEgens via a biomass‐derivatization concept.
Device Performance of Emerging Photovoltaic Materials (Version 4)
Authors: Almora Osbel , Cabrera Carlos I. , Erten‐Ela Sule , Forberich Karen , Fukuda Kenjiro , Guo Fei , Hauch Jens , Ho‐Baillie Anita W. Y. , Jacobsson T. Jesper , Janssen Rene A. J. , Kirchartz Thomas , Loi Maria A. , Mathew Xavier , Mitzi David B. , Nazeeruddin Mohammad K. , Paetzold Ulrich W. , Rand Barry P. , Rau Uwe , Someya Takao , Unger Eva , Vaillant‐Roca Lídice , Brabec Christoph J. 
Published: December 2023

AbstractFollowing the 3rd release of the “Emerging PV reports”, the best achievements in the performance of emerging photovoltaic (e‐PV) devices in diverse e‐PV research subjects are summarized, as reported in peer‐reviewed articles in academic journals since August 2022. Updated graphs, tables, and analyses are provided with several performance parameters, such as power conversion efficiency, open‐circuit voltage, short‐circuit current density, fill factor, light utilization efficiency, and stability test energy yield. These parameters are presented as a function of the photovoltaic bandgap energy and the average visible transmittance for each technology and application, and are put into perspective using, for example, the detailed balance efficiency limit. The 4th installment of the “Emerging PV reports” discusses the “PV emergence” classification with respect to the “PV technology generations” and “PV research waves” and highlights the latest device performance progress in multijunction and flexible photovoltaics. Additionally, Dale‐Scarpulla's plots of efficiency‐effort in terms of cumulative academic publication count are also introduced.