bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stream diatom community assembly processes in islands and continents: A global perspective
Authors: Pérez‐Burillo Javier , Jamoneau Aurélien , Passy Sophia I. , Tison‐Rosebery Juliette , Blanco Saúl , Borrini Alex , Boutry Sébastien , Budnick William R. , Cantonati Marco , Valente Adelaide Clode , Delgado Cristina , Dörflinger Gerald , Gonçalves Vítor , He Siwen , Jyrkänkallio‐Mikkola Jenny , Kennedy Bryan , Marquié Julien , Marques Helena , Papatheodoulou Athina , Pajunen Virpi , Raposeiro Pedro Miguel , Ritter Catarina , Serafim António , Teittinen Anette , Tupola Vilja , Van de Vijver Bart , Wang Jianjun , Wang Beixin , Soininen Janne 
Published: November 2023

AbstractAimUnderstanding the roles of deterministic and stochastic processes in community assembly is essential for gaining insights into the biogeographical patterns of biodiversity. However, the way community assembly processes operate is still not fully understood, especially in oceanic islands. In this study, we examine the importance of assembly processes in shaping diatom communities in islands and continents, while also investigating the influence of climate and local water chemistry variables on species distributions.LocationGlobal.TaxonStream benthic diatoms.MethodsWe used diatom datasets from five continents and 19 islands and applied beta diversity analyses with a null model approach and hierarchical joint species distribution modelling. To facilitate comparisons with continents, we used continental area equivalents (CAEs), which represent continental subsets with comparable areas and the same number of study sites as their corresponding islands counterparts.ResultsWe found that homogeneous selection (i.e., communities being more similar than the random expectation) was the dominant assembly process within islands whereas stochastic processes tended to be more important within continents. In addition, assembly processes were influenced by study scale and island isolation. Climatic variables showed a greater influence on species distribution than local factors. However, in islands, local environmental variables had a greater impact on the distributions of unique taxa as opposed to non‐unique taxa.Main ConclusionsWe observed that the assembly processes of diatom communities were complex and influenced by a combination of deterministic and stochastic forces, which varied across spatial scales. In islands, there was no universal pattern of assembly processes, given that their influence depends on abiotic conditions such as area, isolation, and environmental heterogeneity. In addition, the sensitivity of species occurring uniquely in islands to local environmental variables suggests that they are perhaps less vulnerable to climatic changes but may be more influenced by changes in local physicochemistry.
Genetic variants in hypoxia‐inducible factor pathway are associated with colorectal cancer risk and immune infiltration
Authors: Guo Mengfan , Lin Jie , Cao Xiangming , Zhou Jieyu , Ben Shuai , Chen Silu , Chu Haiyan , Miao Lin , Li Shuwei , Gu Dongying 
Published: November 2023

AbstractHypoxia‐inducible factor (HIF) pathway genes influence tumorigenesis and immune status. However, the associations between genetic variants in hypoxia‐related genes and colorectal cancer risk and the immune status of hypoxia‐associated genes in colorectal cancer have not been systematically characterized. The associations between genetic variants and colorectal cancer risk were evaluated in Chinese, Japanese and European populations using logistic regression analysis. The relationships between target genes and tumour immune infiltration were predicted by Tumour Immune Estimation Resource (TIMER). We found that rs34533650 in EPAS1 was associated with colorectal cancer risk (OR = 1.43, 95% CI = 1.20–1.70, P(FDR) = 8.35 × 10−4), and this finding was validated in two independent populations (Japanese: OR = 1.07, 95% CI = 1.01–1.15, p = 3.38 × 10−2; European: OR = 1.11, 95% CI = 1.03–1.19, p = 6.04 × 10−3). EPAS1‐associated genes were enriched in immune‐related pathways. In addition, we found that EPAS1 copy number variation (CNV) was associated with the degree of infiltration of immune cells and observed correlations between EPAS1 expression and immune cell infiltration levels in colorectal cancer. These results highlight that genetic variants of hypoxia‐related genes play roles in colorectal cancer risk and provide new insight that EPAS1 might be a promising predictor of colorectal cancer susceptibility and immune status.
Home alone or connected: Caregiver communication and training from health providers
Authors: Howe Rebecca J. , Bell Janice F. , Agnoli Alicia , Sullivan Jennifer L. , Bidwell Julie T. 
Published: November 2023

AbstractBackgroundAs care shifts from institutional to community settings, family caregivers are providing increasing support to older adults, including complex medical/nursing care. In the mid‐late pandemic, technology advancements such as use of online patient portals present opportunities for communication and care delivery. This study aims to assess the association between caregiver medical/nursing tasks or patient portal use with contact, communication, and training of caregivers by healthcare providers.MethodsWe conducted a cross‐sectional analysis of caregiver data from the 2021 National Study of Caregiving (NSOC), linked to the National Health and Aging Trends Study (NHATS). NHATS is nationally‐representative, annual survey of Medicare enrollees; NSOC surveys family/unpaid caregivers of NHATS participants. Logistic regression tested association between whether the caregiver does medical/nursing tasks or uses an online patient portal to contact the medical team (independent variables), and communication with or training by the medical team (dependent variables).ResultsParticipants were 1590 caregivers of living, community‐dwelling older adults. More than half (54%) reported no contact with the care recipient's medical team in the past year. Caregivers who did medical/nursing tasks (OR = 3.10; 95% CI: 2.16, 4.46) or who used patient portals (OR = 3.28; 95% CI: 1.96, 5.51) had higher odds of contacting the older adult's medical team. Thirty percent of caregivers stated communication was either not at all or just a little helpful. Sixty‐seven percent reported that providers rarely asked if they needed help managing the older adult's treatments. Just 6% of caregivers reported receiving any caregiver training in the last year.ConclusionsBoth medical/nursing tasks and online patient portal use were independently associated with contact with health providers. Overall contact, communication, and training were limited or of variable value. Despite recent policy changes and technology advancement, there is still a need for improved integration of caregivers into health teams with ongoing assessment of their needs.
Association of the Drug Burden Index (DBI) exposure with outcomes: A systematic review
Authors: Liu Bonnie M. , Kouladjian O'Donnell Lisa , Redston Mitchell R. , Fujita Kenji , Thillainadesan Janani , Gnjidic Danijela , Hilmer Sarah N. 
Published: November 2023

AbstractBackgroundThe Drug Burden Index (DBI) measures an individual's total exposure to anticholinergic and sedative medications. This systematic review aimed to investigate the association of the DBI with clinical and prescribing outcomes in observational pharmaco‐epidemiological studies, and the effect of DBI exposure on functional outcomes in pre‐clinical models.MethodsA systematic search of nine electronic databases, citation indexes and gray literature was performed (April 1, 2007–December 31, 2022). Studies that reported primary data on the association of the DBI with clinical or prescribing outcomes conducted in any setting in humans aged ≥18 years or animals were included. Quality assessment was performed using the Joanna Briggs Institute critical appraisal tools and the Systematic Review Centre for Laboratory animal Experimentation risk of bias tool.ResultsOf 2382 studies screened, 70 met the inclusion criteria (65 in humans, five in animals). In humans, outcomes reported included function (n = 56), cognition (n = 20), falls (n = 14), frailty (n = 7), mortality (n = 9), quality of life (n = 8), hospitalization (n = 7), length of stay (n = 5), readmission (n = 1), other clinical outcomes (n = 15) and prescribing outcomes (n = 2). A higher DBI was significantly associated with increased falls (11/14, 71%), poorer function (31/56, 55%), and cognition (11/20, 55%) related outcomes. Narrative synthesis was used due to significant heterogeneity in the study population, setting, study type, definition of DBI, and outcome measures. Results could not be pooled due to heterogeneity. In animals, outcomes reported included function (n = 18), frailty (n = 2), and mortality (n = 1). In pre‐clinical studies, a higher DBI caused poorer function and frailty.ConclusionsA higher DBI may be associated with an increased risk of falls and decreased function and cognition. Higher DBI was inconsistently associated with increased mortality, length of stay, frailty, hospitalization or reduced quality of life. Human observational findings with respect to functional outcomes are supported by preclinical interventional studies. The DBI may be used as a tool to identify older adults at higher risk of harm.
Flight to Safety or Liquidity? Dissecting Liquidity Shortages in the Financial Crisis
Authors: DONG FENG , WEN YI 
Published: November 2023

AbstractWe differentiate the liquidity and the quality of private assets in a tractable incomplete‐market model with heterogeneous agents. The model decomposes the convenience yield of government bonds into a “liquidity premium” (flight to liquidity) and a “safety premium” (flight to quality) over the business cycle. When calibrated to match the U.S. aggregate output fluctuations and bond premiums, the model reveals that a sharp reduction in the quality, instead of the liquidity, of private assets was the culprit of the recent financial crisis, consistent with the perception that it was the subprime‐mortgage problem that triggered the Great Recession. Since the provision of public liquidity endogenously affects the provision of private liquidity, our model indicates that excessive injection of public liquidity during a financial crisis can be welfare reducing under either conventional or unconventional policies. In particular, too much intervention for too long can depress capital investment.
Phenotypic response of a core collection of Aegilops triuncialis accessions to wheat leaf rust and expression pattern of genes involved in resistance
Authors: Hosseini Marzieh Sadat , Davoudnia Behnam , Dadkhodaie Ali , Heidari Bahram 
Published: November 2023

AbstractLeaf rust caused by Puccinia triticina Eriks. is a serious threat to wheat production worldwide. Exploiting wild relatives can effectively help to improve the genetic resistance of wheat against rust. This study aimed to evaluate the responses of 34 Aegilops triuncialis accessions to seven Pt pathotypes and to analyse expression of genes associated with resistance at the seedling stage. Following multipathotype testing, two accessions with contrasting resistance were analysed at 0, 6, 12 and 24 h post‐inoculation for the expression profile of genes related to PR1, PR2, PR4, PR9, phenylalanine ammonia‐lyase and ATP‐binding cassette transporter. Of the accessions tested, eight showed high infection types of “3” to at least one Pt pathotype, while the remaining accessions had low ITs (“0;=” to “2+”) against all pathotypes. The relative expressions of all candidate genes increased at all‐time points, but the expression level in the incompatible interaction was significantly higher than that of the compatible. The close relationship between PR proteins, PAL, salicylic acid‐ and jasmonic acid‐responsive proteins, as well as the proteins involved in the production of reactive oxygen species and lignin, could point to the specific recognition of the pathogen followed by the timely and intense induction of the expression of PR genes as the main reasons for resistance in incompatible interaction. In conclusion, the present study identified potentially new sources of resistance in this Ae. triuncialis population, which can be exploited in wheat breeding programs.
Prevalence of nonconvulsive seizures and nonconvulsive status epilepticus in dogs and cats with a history of cluster seizures: A retrospective study
Authors: Tästensen Carina , Gutmann Sarah , Loderstedt Shenja , Flegel Thomas , Demeny Helga , Baum Petra 
Published: November 2023

AbstractBackgroundNonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) are frequently observed in human patients. Diagnosis of NCS and NCSE only can be achieved by the use of electroencephalography (EEG). Electroencephalographic monitoring is rare in veterinary medicine and consequently there is limited data on frequency of NCS and NCSE.ObjectivesDetermine the prevalence of NCS and NCSE in dogs and cats with a history of cluster seizures.AnimalsTwenty‐six dogs and 12 cats.MethodsRetrospective study. Medical records of dogs and cats with cluster seizures were reviewed. Electroencephalography was performed in order to identify electrographic seizure activity after the apparent cessation of convulsive seizure activity.ResultsNonconvulsive seizures were detected in 9 dogs and 2 cats out of the 38 patients (29%). Nonconvulsive status epilepticus was detected in 4 dogs and 2 cats (16%). Five patients had both NCS and NCSE. A decreased level of consciousness was evident in 6/11 patients with NCS, 3/6 also had NCSE. Mortality rate for patients with NCS (73%) and NCSE (67%) was much higher than that for patients with no seizure activity on EEG (27%).Conclusion and Clinical ImportancePrevalence of NCS and NCSE is high in dogs and cats with a history of cluster seizures. Nonconvulsive seizures and NCSE are difficult to detect clinically and are associated with higher in hospital mortality rates. Results indicate that prompt EEG monitoring should be performed in dogs and cats with cluster seizures.
Time‐inconsistent contract theory
Authors: Hernández Camilo , Possamaï Dylan 
Published: November 2023

AbstractThis paper investigates the moral hazard problem in finite horizon with both continuous and lump‐sum payments, involving a time‐inconsistent sophisticated agent and a standard utility maximizer principal: Building upon the so‐called dynamic programming approach in Cvitanić et al. (2018) and the recently available results in Hernández and Possamaï (2023), we present a methodology that covers the previous contracting problem. Our main contribution consists of a characterization of the moral hazard problem faced by the principal. In particular, it shows that under relatively mild technical conditions on the data of the problem, the supremum of the principal's expected utility over a smaller restricted family of contracts is equal to the supremum over all feasible contracts. Nevertheless, this characterization yields, as far as we know, a novel class of control problems that involve the control of a forward Volterra equation via Volterra‐type controls, and infinite‐dimensional stochastic target constraints. Despite the inherent challenges associated with such a problem, we study the solution under three different specifications of utility functions for both the agent and the principal, and draw qualitative implications from the form of the optimal contract. The general case remains the subject of future research. We illustrate some of our results in the context of a project selection contracting problem between an investor and a time‐inconsistent manager.
Nanophase magnetite in matrix of anomalous EL3 chondrite Northwest Africa (NWA) 8785
Authors: Weisberg M. K. , Zolensky M. E. , Kimura M. , Howard K. T. , Ebel D. S. , Gray M. L. , Alexander C. M. O'D. 
Published: November 2023

AbstractNWA 8785 is a remarkable EL3 chondrite with a high abundance (~34 vol%) of an Fe‐rich matrix. This is the highest matrix abundance known among enstatite chondrites (ECs) and more similar to the matrix abundances in some carbonaceous and Rumuruti chondrites. X‐ray diffraction and TEM data indicate that the fine‐grained portion of the NWA 8785 matrix consists of nanoscale magnetite mixed with a noncrystalline silicate material and submicron‐sized enstatite and plagioclase grains. This is the first report of magnetite nanoparticles in an EL3. The Si content of the metal (0.7 wt%), presence of ferroan alabandite, and its O isotopic composition indicate NWA 8785 is EL3‐related. Having more abundant matrix than in other ECs, and that the matrix is rich in magnetite nanoparticles, which are not present in any other EC, suggest classification as an EL3 anomalous. Although we cannot completely exclude any of the mechanisms or environments for formation of the magnetite, we find a secondary origin to be the most compelling. We suggest that the magnetite formed due to hydrothermal activity in the meteorite parent body. Although ECs are relatively dry and likely formed within the nebular snow line, ices may have drifted inward from just beyond the snow line to the region where the EL chondrites were accreting, or more likely the snow line migrated inward during the early evolution of the solar system. This may have resulted in the condensation of ices and provided an ice‐rich region for accretion of the EL3 parent body. Thus, the EL3 parent body may have had hydrothermal activity and if Earth formed near the EC accretion zone, similar bodies may have contributed to the Earth's water supply. NWA 8785 greatly extends the range of known characteristics of ECs and EC parent body processes.
The Golden meteorite fall: Fireball trajectory, orbit, and meteorite characterization
Authors: Brown P. G. , McCausland P. J. A. , Hildebrand A. R. , Hanton L. T. J. , Eckart L. M. , Busemann H. , Krietsch D. , Maden C. , Welten K. , Caffee M. W. , Laubenstein M. , Vida D. , Ciceri F. , Silber E. , Herd C. D. K. , Hill P. , Devillepoix H. , Sansom Eleanor K. , Cupák Martin , Anderson Seamus , Flemming R. L. , Nelson A. J. , Mazur M. , Moser D. E. , Cooke W. J. , Hladiuk D. , Malečić Barbara , Prtenjak Maja Telišman , Nowell R. ,   The Golden Meteorite Consortium
Published: November 2023

AbstractThe Golden (British Columbia, Canada) meteorite fall occurred on October 4, 2021 at 0534 UT with the first recovered fragment (1.3 kg) landing on an occupied bed. The associated fireball was recorded by numerous cameras permitting reconstruction of its trajectory and orbit. The fireball entered the atmosphere at a 54° angle from the horizontal at a speed of 18 km s−1. The fireball reached a peak brightness of −14, having first become luminous at a height of >84 km and ending at 18 km altitude. Analysis of the infrasonic record of the bolide produced an estimated mass of kg while modeling of the fireball light curve suggests an initial mass near 70 kg. The fireball experienced a major flare near 31 km altitude where more than half its mass was lost in the form of dust and gram‐sized fragments under a dynamic pressure of 3.3 MPa. The strength and fragmentation behavior of the fireball were similar to those reported for other meteorite‐producing fireballs (Borovička et al., 2020). Seven days after the fireball occurred, an additional 0.9 kg fragment was recovered during the second day of dedicated searching guided by initial trajectory and dark flight calculations. Additional searching in the fall and spring of 2021–2022 located no additional fragments. The meteorite is an unbrecciated, low‐shock (S2) ordinary chondrite of intermediate composition, typed as an L/LL5 with a grain density of ~3530 k gm−3, an average bulk density of 3150 kg m−3 and calculated porosity of ~10%. From noble gas measurements, the cosmic ray exposure age is 25 ± 4 Ma while gas retention ages are all >2 Ga. Short‐lived radionuclides and noble gas measurements of the pre‐atmospheric size overlap with estimates from infrasound and light curve modeling producing a preferred pre‐atmospheric mass of 70–200 kg. The orbit of Golden has a high inclination (23.5°) and is consistent with delivery from the inner main belt. The highest probability (60%) of an origin is from the Hungaria group. We propose that Golden may originate among the background S‐type asteroids found interspersed in the Hungaria region. The current collection of 18 L/LL—chondrite orbits shows a strong preference for origins in the inner main belt, suggesting multiple parent bodies may be required to explain the diversity in CRE ages and shock states.
Geophysical and structural analyses of the Middlesboro impact structure, Kentucky, USA: Reactivation of a thrust detachment of the Appalachian foreland fold‐and‐thrust belt
Authors: Wihanto Lars , Kenkmann Thomas 
Published: November 2023

AbstractThis paper reports on the Middlesboro impact structure (36°37′03″ N; 83°43′39″ W), a complex impact structure located in the Appalachian foreland fold‐and‐thrust belt of southeast Kentucky, USA. The structure forms a basin approximately 5.5 km in diameter exposing intensely deformed Pennsylvanian sediments. Based on field data, microstructural observation, and geophysical analyses we qualitatively assess degree and distribution of fragmentation of target rocks within the impact structure. Shock deformation features, especially feather features, are reported for the impact structure. Shallow seismic refraction data were acquired along a radial profile from outside the impact structure to the center of the structure. Seismic (P‐wave) velocity trends indicate that fracture intensity increases toward the center, reducing the overall seismic velocity. However, intense rock sealing in some parts of the central uplift increases the strength of rock samples and locally increases seismic velocities. We present a modified geologic map of the Middlesboro impact structure based on high‐resolution lineament analysis, field work, and reevaluation of existing structural data from geologic maps. The modified map suggests that crater circularity at Middlesboro is skewed by the reactivation of pre‐existing zones of structural anisotropy in the target. We propose that due to an oblique impact from northerly direction the sub‐horizontal Pine Mountain thrust plane beneath the impact structure became reactivated with a top‐to‐the south shear component. The impact‐induced formation/reactivation of the Doublings Fault Zone as a thrust ramp appears to have deflected the otherwise straight strike of the Cumberland Mountains southward. The Rocky Face fault approaches the crater rim fault, and we propose that this sinistral strike‐slip fault was formed, or at least reactivated, by the impact and accommodated the oblique impact's horizontal momentum.