bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective comparative study of anesthesia with remimazolam and remifentanil versus dexmedetomidine and remifentanil for transcatheter aortic valve replacement
Authors: Kitaura Atsuhiro , Tsukimoto Shota , Sakamoto Hiroatsu , Hamasaki Shinichi , Nakao Shinichi , Nakajima Yasufumi 
Published: October 2023

AbstractRemimazolam, an ultrashort-acting benzodiazepine, allows for rapid and reliable arousal. Rapid awakening using remimazolam may be beneficial in transcatheter aortic valve replacement (TAVR), as it allows rapid detection of neurologic deficits. The purpose of this study was to compare arousal time and outcomes between monitored anesthesia care (MAC) with remimazolam and remifentanil and conventional MAC with dexmedetomidine, propofol, and remifentanil. This study was a single center retrospective study. All TAVR cases performed under MAC (MAC-TAVR) at our institution between 2019 and 2021 were included. Patients were classified by anesthesia method into remimazolam and dexmedetomidine groups. Among 258 MAC-TAVR patients, 253 were enrolled. After propensity score matching, 76 patients were assigned to each group. The time from end of drug-administration to arousal [20.0 (16.0, 24.0) min vs. 38.5 (30.0, 56.3) min, p < 0.0001] and the time from attempted-arousal to arousal [1.0 (1.0, 1.0) min vs. 12.5 (3.0, 26.8) min, p < 0.0001] were significantly shorter in the remimazolam group. There was no significant difference in the length of ICU stay [2.0 (2.0, 2.0) days vs. 2.0 (2.0, 2.0) days, p = 0.157] and postoperative hospital stay [6.0 (4.0, 9.0) days vs. 5.0 (4.0, 8.0) days, p = 0.262].Trial registration: Clinical trial number: R03-123,
Registry URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051635
Registration number: UMIN000045195, Principal investigator's name: Atsuhiro Kitaura,
Date of registration: 20 August 2021.
Design-driven regional industry transformation and upgrading under the perspective of sustainable development
Authors: You Lisi , Ji Tie , Shao Binbin , Wu Xiaojing , Shi Lei 
Published: October 2023

AbstractThis study combines relevant theories and methods from economics and ecology to investigate design-driven transformation and upgrade paths for the long-term success of regional industries in the context of sustainable transformation, drawing on the design research literature's emphasis on sustainability, synergy, and a systemic approach. This evaluation may be thought of as a precondition for transformation. The regional industrial base dictates the upgrading route for sustainable transformation. Huaihua, a prefecture-level city in Hunan Province, China, serves as a case study for this investigation. Huaihua City's ecological footprints, human development index, and ecological welfare performance are used to evaluate the region's industrial base. A system based on quantitative data criteria and hierarchical analysis was built to choose top regional industries. The design study has promising implications for the sustainable transformation of major regional industries since it is an interdisciplinary, collaborative, and methodical type of research. Huaihua City, as a representative region of the less developed southwest region in China, designs a sustainable industrial transformation and upgrading path by providing a theoretical basis and quantitative measurement criteria for the sustainable transformation of regional industries.
Multiclass malaria parasite recognition based on transformer models and a generative adversarial network
Authors: Tan Dianhuan , Liang Xianghui 
Published: October 2023

AbstractMalaria is an extremely infectious disease and a main cause of death worldwide. Microscopic examination of thin slide serves as a common method for the diagnosis of malaria. Meanwhile, the transformer models have gained increasing popularity in many regions, such as computer vision and natural language processing. Transformers also offer lots of advantages in classification task, such as Fine-grained Feature Extraction, Attention Mechanism etc. In this article, we propose to assist the medical professionals by developing an effective framework based on transformer models and a generative adversarial network for multi-class plasmodium classification and malaria diagnosis. The Generative Adversarial Network is employed to generate extended training samples from multiclass cell images, with the aim of enhancing the robustness of the resulting model. We aim to optimize plasmodium classification to achieve an exact balance of high accuracy and low resource consumption. A comprehensive comparison of the transformer models to the state-of-the-art methods proves their efficiency in the classification of malaria parasite through thin blood smear microscopic images. Based on our findings, the Swin Transformer model and MobileVit outperform the baseline architectures in terms of precision, recall, F1-score, specificity, and FPR on test set (the data was divided into train: validation: test splits). It is evident that the Swin Transformer achieves superior detection performance (up to 99.8% accuracy), while MobileViT demonstrates lower memory usage and shorter inference times. High accuracy empowers healthcare professionals to conduct precise diagnoses, while low memory usage and short inference times enable the deployment of predictive models on edge devices with limited computational and memory resources.
Simulation and optimization of rectenna systems
Authors: Olaimat Melad M. , Nayyeri Vahid , Ramahi Omar M. 
Published: October 2023

AbstractIn this paper, we present an entirely simulation-based method to predict the performance of a complete rectenna system that includes all its components: the receiving antenna, the matching circuits between the antenna and the rectification circuit, and the load circuit. Whereas previous efforts to predict the performance of a rectenna system subdivided the system into the antenna part (radiation to AC power conversion) and the circuit part (AC power to DC power conversion), and made assumptions about the performance of the non-linear part of the rectenna based on a specified power level and frequency, in this method, the radiation part of the system is incorporated into the simulation by using Thevenin theorem. The method proposed in this work enables the rectenna designer to predict the performance of the complete rectenna system, at the design stage, for variation in the incident field’s power density, angle of incidence, and operating frequency. Such performance prediction was not available before. Furthermore, the proposed method enables the rectenna designers to optimize the entire system over a portion of or the entire range of the operating frequency. Experimental results are provided to demonstrate the accuracy of the method.
Emotional associative memory is disrupted by directed forgetting
Authors: Chalkia Anastasia , Vanhasbroeck Niels , Van Oudenhove Lukas , Kindt Merel , Beckers Tom 
Published: October 2023

AbstractMemory is susceptible to voluntary disruption, for instance, through directed forgetting manipulations, in which people are cued to intentionally “forget” information. Until now, directed forgetting has been primarily studied for declarative memory performance. Here, we demonstrate that directed forgetting can also disrupt associative memories acquired through fear conditioning. In two experiments, participants showed poorer recognition and recall of images paired with electric shocks when instructed to forget, compared to when instructed to remember them. Further, they also showed weaker skin conductance responses to images paired with shocks that they were instructed to forget, despite repeated, full reinforcement of the aversive outcome. Our findings provide evidence for the effect of directed forgetting not only on declarative but also physiological read-outs of emotional memory, thereby suggesting that forgetting instructions can be applied to interfere with emotional associative memory.
The EDIBLES survey
Authors: Fan Haoyu , Rocha Carlos M. R. , Cordiner Martin , Linnartz Harold , Cox Nick L. J. , Farhang Amin , Smoker Jonathan , Roueff Evelyne , Ehrenfreund Pascale , Salama Farid , Foing Bernard H. , Lallement Rosine , MacIsaac Heather , Kulik Klay , Sarre Peter , van Loon Jacco Th. , Cami Jan 
Published: October 2023

Context. Small linear carbon chain radicals such as C2 and C3 act as both the building blocks and dissociation fragments of larger carbonaceous species. Their rotational excitation traces the temperature and density of local environments. However, these homo-nuclear di- and triatomic species are only accessible through their electronic and vibrational features because they lack a permanent dipole moment, and high signal-to-noise ratio data are necessary as the result of their generally low abundances in the interstellar medium (ISM).
Aims. In order to improve our understanding of small carbonaceous species in the ISM, we carried out a sensitive survey of C2 and C3 using the ESO Diffuse Interstellar Bands Large Exploration Survey (EDIBLES) dataset. We also expanded our searches to C4, C5, and the 13C12C isotopologue in the most molecule-rich sightlines.
Methods. We fitted synthetic spectra generated following a physical excitation model to the C2 (2-0) Phillips band to obtain the C2 column density (N) as well as the kinetic temperature (Tkin) and number density (n) of the host cloud. The C3 molecule was measured through its Ã − $ \tilde X$ (000-000) electronic origin band system. We simulated the excitation of this band with a double-temperature Boltzmann distribution.
Results. We present the largest combined survey of C2 and C3 to date in which the individual transitions can be resolved. In total, we detected C2 in 51 velocity components along 40 sightlines, and C3 in 31 velocity components along 27 sightlines. Further analysis confirms the two molecules are detected in the same velocity components. We find a very good correlation between N(C2) and N(C3) with a Pearson correlation coefficient r = 0.93 and an average N(C2)/N(C3) ratio of 15.5± 1.4. A comparison with the behaviour of the C2 diffuse interstellar bands (DIBs) shows that there are no clear differences among sightlines with and without detections of C2 and C3. This is in direct contrast to the better-studied non-C2 DIBs, which have reduced strengths in molecule-rich environments, consistent with the idea that the C2 DIBs are indeed a distinguishable DIB family. We also identify, for the first time, the Q(2), Q(3), and Q(4) transitions of the 13C12C (2-0) Phillips band in the stacked average spectrum of molecule-rich sightlines, and estimate the isotopic ratio of carbon 12C/13C to be 79±8, consistent with literature results. At this stage it is not yet possible to identify these transitions in individual sightlines. Our search for the C4 and C5 optical bands was unsuccessful; even in stacked spectra no unambiguous identification could be made.
A fresh perspective on the 3D dynamics of Tycho’s supernova remnant: Ejecta asymmetries in the X-ray band
Authors: Godinaud L. , Acero F. , Decourchelle A. , Ballet J. 
Published: October 2023

Context. Even 450 yr after the explosion of the Type Ia SN 1572, the dynamics of the Tycho supernova remnant (Tycho’s SNR) can offer keys to improving our understanding of the explosion mechanism and the interaction of the remnant with the interstellar medium.
Aims. To probe the asymmetries and the evolution of the SNR, we tracked the ejecta dynamics using new methods applied to the deep X-ray observations available in the Chandra space telescope archive.
Methods. For the line-of-sight (LoS) velocity measurement (Vz), we used the Doppler effect focused on the bright Si line in the 1.6-2.1 keV band. Using the component separation tool called general morphological component analysis (GMCA), we successfully disentangled the red and blueshifted Si ejecta emission. This allowed us to reconstruct a map of the peak energy of the silicon line with a total coverage of the SNR at a 2″ resolution. We then obtained a proxy of the integrated velocity along the LoS. For the proper motions in the plane of the sky (Vxy), we developed a new method, called Poisson optical flow (POF), to measure the displacement of two-dimensional (2D) features between the observations of 2003 and 2009. The result is a field of around 1700 velocity vectors covering the entire SNR.
Results. These exhaustive three-dimensional (3D) velocity measurements reveal the complex dynamics of Tycho’s SNR. Our study sheds light on a patchy Vz map, where most regions are dominated by the foreground or the background part of the shell. On a large scale, an asymmetry is seen, with the north being dominantly blueshifted and the south redshifted. The proper-motion vector field, Vxy, highlights different dynamics between the eastern and the western parts of the SNR. The eastern velocity field is more disturbed by external inhomogeneities and the south-east ejecta knot. In particular, a slow-down is observed in the north-east, which could be due to the interaction with higher densities, as seen in other wavelengths. The vector field is also used to backtrace the center of the explosion, which is then compared with potential stellar progenitors in the area. The latest Gaia DR3 parallax measurements exclude most stellar candidates based on their distances, leaving only stars B and E as possible candidates, at respective distances of 2.53−0.20+0.23 kpc and 3.52−1.0+2.0 kpc, which are consistent with the expected distance range of the SNR at 2.5–4 kpc.
Sterbeortentwicklung über zwei Jahrzehnte in der Stadt
Münster – eine Observationsstudie auf Basis ausgewerteter
Todesbescheinigungen
Authors: Dasch Burkhard 
Published: October 2023

ZusammenfassungZiel der Studie Die Studie untersuchte die Sterbeortverteilung in der
westfälischen Stadt Münster über einen
Beobachtungszeitraum von 20 Jahren.Methode Sämtliche
Todesbescheinigungen der Stadt Münster der Jahre 2001, 2011, 2017, 2021
wurden nach dem Sterbeort (Zuhause (HA), Krankenhaus (KH), Hospiz (HO),
Pflegeheim (PH), sonstiger Ort (SO)) ausgewertet. Für
Krankenhauspatienten wurden zudem Sterbefälle auf Intensivstationen
(ICU) und Palliativstationen (PAL) separat betrachtet. Jegliche
ärztliche Angabe zur Todesursache wurde herangezogen, um Verstorbene mit
einer bösartigen Tumorerkrankung bzw. mit einer dementiellen Erkrankung
zu identifizieren..Ergebnisse Insgesamt wurden 14.240
Todesbescheinigungen ausgewertet. In 34,0% war eine bösartige
Tumorerkrankung, in 11,1% eine Demenzerkrankung dokumentiert worden. Die
Sterbeortverteilung für die Allgemeinbevölkerung war wie folgt
verteilt (2001/2021; %): HA (24,0/14,6); KH
(63,2/60,2) [ICU (13,3/24,6), PAL (0,0/10,9)], HO
(3,8/4,9), PH (7,8/19,5), SO (1,1/0,7). Tumorerkrankte
verstarben primär im Krankenhaus (2021: 60,6%), selten Zuhause
(2021: 15,4%). Von 2001 bis 2021 stieg der Anteil auf einer
Palliativstation verstorbener Krebspatienten deutlich an
(+24,4%); Hospize verzeichnete einen moderaten Anstieg
(+5,0%). Demenzerkrankte verstarben überwiegend in
Pflegeheimen (2021: 66,6%) und in geringer Häufigkeit Zuhause
(2021: 12,2%).Schlussfolgerung Für die
Allgemeinbevölkerung und für Tumorerkrankte stellt im Jahr 2021
das Krankenhaus, für Demenzerkrankte das Pflegeheim den
häufigsten Sterbeort dar. Insgesamt nehmen Sterbefälle Zuhause
über die Zeit kontinuierlich ab. Bei Tumorerkrankten erlangen
Palliativstationen und Hospize, bei demenzerkrankten Personen besonders
stationäre Pflegeheime als Sterbeorte eine zunehmende Bedeutung.
Anthroposophische Medizin bei Neurodermitis im Kindesalter
Authors: Michael Karin 
Published: October 2023

ZusammenfassungDie Neurodermitis im Kindesalter ist ein multifaktorielles Krankheitsgeschehen und häufiges Thema in der pädiatrischen und hausärztlichen Sprechstunde. Aufgrund der Komplexität der Ursachen, der Neigung zu langwierigen Verläufen oder der Umwandlung in andere Erkrankungen des atopischen Formenkreises ist dieses Krankheitsbild ein häufiger Anlass zur Frage der Eltern nach integrativmedizinischen Therapieansätzen. Die Anthroposophische Medizin ist als integrative Heilmethode immer bemüht, dem Menschen auf allen Ebenen seines Daseins gerecht zu werden. Bei chronischen Hauterkrankungen wie der Neurodermitis erscheint das unverzichtbar. So kann schon ein einziger aufregender Tag für ein Kind mit Neurodermitis eine massive Verschlechterung des Hautbildes und eine entsprechend von seinem Juckreiz beherrschte schlaflose Nacht für die ganze Familie bedeuten. Der Beitrag beschreibt einige grundlegende Aspekte der Herangehensweise dieser Heilmethode.
Positionspapier zur Implementierung eines nationalen organisierten Programms
in Deutschland zur Früherkennung von Lungenkrebs in Risikopopulationen mittels
Low-Dose-CT-Screening inklusive Management von abklärungsbedürftigen
Screening-Befunden
Authors: Hoffmann Hans , Kaaks Rudolf , Andreas Stefan , Bauer Torsten T. , Barkhausen Jörg , Harth Volker , Kauczor Hans-Ulrich , Pankow Wulf , Welcker Katrin , Vogel-Claussen Jens , Blum Torsten Gerriet ,   Deutsche Röntgengesellschaft (Vorstand der Deutschen
          Röntgengesellschaft: Prof. Dr. med. Konstantin Nikolaou, Prof. Dr. med. Jörg Barkhausen,
          Prof. Dr. med. Christiane Kuhl, Dr. rer. nat. Frank Anton, Dr. med. Stefan Neuman, Prof.
          Dr. med. Arnd Dörfler, PD Dr. med. Friederike Körber, Prof. Dr. rer. medic. Martin
          Fiebich, Prof. Dr. med. Gerald Antoch, Dr. med. Kerstin Westphalen, Prof. Dr. Ulrike
          Attenberger, Prof. Dr. med. Frank Wacker, Prof. Dr. med. Johannes
          Weßling),   Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin (Vorstand
          der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin: Prof. Dr. med. Wolfram
          Windisch, Prof. Dr. med. Christian Taube, Prof. Dr. med. Torsten T. Bauer, Prof. Dr. med.
          Antje Prasse),   Deutsche Gesellschaft für Thoraxchirurgie (Vorstand der Deutschen
          Gesellschaft für Thoraxchirurgie: Dr. med. Katrin Welcker, Dr. med. Ludger Hillejan, Prof.
          Dr. med. Hans-Stefan Hofmann, PD Dr. med. habil. Robert Scheubel, Dr. med. Erich Hecker,
          Prof. Dr. med. Corinna Ludwig, Prof. Dr. med. Thorsten Walles, Prof. Dr. med. Hauke
          Winter)
Published: October 2023

ZusammenfassungDer Prozess zur Implementierung der Lungenkrebsfrüherkennung mit Niedrigdosis-CT (LDCT)
in Deutschland hat in den letzten Jahren deutlich an Dynamik gewonnen. Es wird erwartet,
dass der von den Fachgesellschaften kommentierte Referentenentwurf des Bundesministeriums
für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz (BMUV) zur
Lungenkrebsfrüherkennung noch bis Ende 2023 in Kraft tritt. Basierend auf dieser
Verordnung wird der Gemeinsame Bundesausschuss (G-BA) zeitnah ein Programm zur
Lungenkrebsfrüherkennung mit LDCT aufsetzten. In diesem Positionspapier stellen die im
Lungenkrebs-Screening beteiligten Fachgesellschaften erstmals konkrete Eckpunkte für ein
einheitliches, strukturiertes und qualitätsgesichertes Früherkennungsprogramm für
Lungenkrebs in Deutschland vor, um zu diesem Prozess konstruktiv beizutragen.
Complications of the Rigid Spine
Authors: Vanhoenacker Filip M. , Vanhoenacker Charlotte , Lalam Radhesh 
Published: October 2023

AbstractWe present a short overview of the most common causes and imaging findings of a rigid spine including long-standing spondylarthritis, diffuse idiopathic skeletal hyperostosis, and the less common ossification of the posterior longitudinal ligament. The article also focuses on the pathogenesis and imaging findings of acute complications of the rigid spine due to fractures. These fractures may occur even after minor trauma and are difficult to detect on initial radiographs, resulting in a delayed diagnosis. They are often unstable with a high risk of severe neurologic complications, leading to high morbidity and mortality both in the initial phase and in the months following the fracture. Because the negative predictive value of conventional radiography is low, every patient with a rigid spine with newly appearing pain should be referred for subsequent cross-sectional imaging.
Imaging the Posterior Elements of the Spine
Authors: Eede Nick Van den , Friedrich Klaus M. , Hauwe Luc van den 
Published: October 2023

AbstractThe posterior elements of the spine consist of the pedicles, laminae, facets (articular processes), transverse processes, and the spinous process. They are essential for spinal stability, protecting the spinal cord and nerve roots, and enabling movement of the spine. Pathologies affecting the posterior elements can cause significant pain and disability. Imaging techniques, such as conventional radiography, computed tomography, and magnetic resonance imaging, are crucial for the diagnosis and evaluation of pathology, enabling accurate localization, characterization, and staging of the disease.
What the Musculoskeletal Radiologist Needs to Know About the Vascular Anatomy of the Spine and Spinal Cord
Authors: Duarte Armindo Rui , Vilela Pedro 
Published: October 2023

AbstractThis article describes the vascular anatomy of the spine and spinal cord, highlighting key structures and anatomical variations relevant to musculoskeletal radiologists. It covers the arterial and venous drainage systems, along with examples of vascular conditions affecting the spine. Understanding the vascular anatomy of the spine and spinal cord is crucial for accurate interpretation of imaging studies and safe spinal interventional procedures. Imaging techniques for evaluating vascular pathology of the spine are discussed and compared. Understanding vascular anatomy and the most common vascular disorders will lead to an accurate diagnosis and suggest the appropriate type of study needed for further characterization and/or patient management.
The Clinical Efficacy and Safety of Acute Care Setting for Intravenous Levetiracetam (Focale) in Children
Authors: Tiamkao Siriporn , Ruangritkul Preechaya , Chainirun Nanthaphan , Hutthawanichakornkul Tarnthip , Bungtong Issara , Thongjankaew Pinjutha , Mungmanitmongkol Sineenard , Tiamkao Somsak , Auvichayapat Narong , Sawanyawisuth Kittisak ,   on Behalf of Integrated Epilepsy Research Group, Khon Kaen University
Published: October 2023

Abstract
Background Status epilepticus (SE) is a serious neurological emergency with a high mortality rate. Although levetiracetam is an effective antiepileptic drug for managing SE, its excessive cost may limit its accessibility. Focale, a more affordable generic version, is currently available and is more than 50% less expensive than the original version. However, there is currently no study on the efficacy and safety of Focale in pediatric patients with SE.
Objective This study aimed to investigate the efficacy and safety of the antiepileptic drug, Focale, in pediatric patients.
Materials and Methods This was a retrospective study that examined 131 pediatric patients younger than 18 years, who were treated with Focale for seizure control and prevention between June 2019 and November 2022.
Results A total of 131 patients were included in the study, of which 73 (55.7%) were male. The age group with the highest frequency was 0 to 3 years old (28.2%). Focale was used with the following indications: (1) SE (45.04%), (2) acute repetitive convulsive seizures (22.14%), (3) primary prophylaxis (26.72%), (4) acute first seizure (1.52%), and (5) patients with epilepsy with nothing per oral (4.58%). Regarding the outcomes, the seizure-controlled rate in the seizure group was 81.1%, while the seizure prevention rate was 92.7% for those who received Focale as a seizure prophylaxis. Only 2 out of 131 patients had experienced adverse effects (1.5%).
Conclusion The generic intravenous levetiracetam treatment had high seizure-controlled rate in patients with seizure attacks and seizure prevention rate in the seizure prophylaxis group in pediatric patients. Side effects of this regimen in pediatric patients were low.