bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Ice Massage Applied to the SP6 Point on Labor Pain, Labor Comfort, Labor Duration, and Anxiety: A Randomized Clinical Trial
Authors: Türkmen Hülya , Çetinkaya Serap , Kiliç Hafize , Tuna Serpil Dinçer , Şirvanci Mehmet , Mutlu Hilmi 
Published: January 2024

IntroductionAcupressure and cold application are nonpharmacologic methods that midwives can use for labor pain. The purpose of this study was to determine the effects of ice massage applied to the SP6 acupressure point during labor on labor pain, labor comfort, labor duration, and anxiety.MethodsA single‐masked, randomized controlled trial was conducted with 100 nulliparous women, including 50 in the intervention group and 50 in the control group. Rotational ice massage was applied to the SP6 point on both legs of the pregnant women in the intervention group at 4 to 5 cm, 6 to 7 cm, and 8 to 9 cm dilation amounts during 3 contractions. Routine oxytocin was administered to all pregnant women to promote progress of labor. Standard midwifery care was provided to the control group. Data were collected using a Personal Information Form, the Visual Analog Scale (VAS), a partograph form, the Childbirth Comfort Questionnaire (CCQ), and the State‐Trait Anxiety Inventory State subscale.ResultThe VAS pain scores of the pregnant women in the intervention group were significantly lower compared with the control group following the intervention at dilatations of 4 to 5 cm, 6 to 7 cm, and 8 to 9 cm (P = .001, P = .003, P <.001, respectively). The total CCQ and comfort level scores of the pregnant women in the intervention group at 8 to 9 cm cervical dilatation were significantly higher than the control group (P = 0.044, P = .027, respectively). Additionally, as the anxiety levels of the pregnant women increased, their total comfort scores decreased (P <.05).DiscussionIce application to the SP6 point during stage 1 of childbirth reduced labor pain, increased comfort, and reduced anxiety levels. No adverse events were found in the intervention group with ice massage applied to the SP6 point. Therefore, this method can be used as a safe and effective midwifery intervention in childbirth.
Faecal cortisol levels in a wild Iberian red deer population are best explained by prior weather conditions
Authors: Gort‐Esteve A. , Carbajal A. , López M. , Manteca X. , Ruiz‐Olmo J. , Riera J. L. 
Published: January 2024

AbstractThe responsiveness of the hypothalamic–pituitary‐adrenocortical axis to stressors is crucial for wild animals to survive and adapt to environmental changes without compromising individual welfare. We analysed the influence of prior weather conditions, seasonality, the influx of ecotourism, and nutrition on stress levels in a wild population of red deer in a Mediterranean hunting reserve in the Pre‐Pyrenees, Spain. We used faecal cortisol metabolites as a proxy for physiological and psychological stress, and faecal triiodothyronine metabolites as an indicator of nutritional stress. Faecal analyses were chosen because it is a non‐invasive technique that does not alter an individual's behaviour, and it is easy to conduct in a wild population, something which presents added challenges due to the lack of a controlled environment. Our results indicate that prior weather conditions, rather than just seasonality, best explained the variations in these hormones within seasons and among years. On the contrary, the results showed that high levels of the cortisol hormone did not necessarily correspond to low levels of the triiodothyronine hormone. This could be a sign of acute nutritional stress in this population. Finally, we did not find an effect of the ecotourism influx on cortisol levels, suggesting that this deer population tolerates the presence of tourists.
How does the use of evidence in policy narratives change during crises? A comparative study of New York City's pandemic school shutdowns
Authors: Klatt Nikolina , Blum Sonja 
Published: January 2024

AbstractNarratives play an essential role in fast‐paced policy making that occurs during crises. The COVID‐19 pandemic brought numerous disruptions of normality, including school closures, which were intensely debated in narratives by many policy actors. Two shutdowns of New York City's public school system affected over 1.1 million students. This article investigates how scientific evidence was used in the narratives surrounding the school shutdowns in NYC by analyzing around 160 policy narratives with the Narrative Policy Framework. We ask whether and how the growing certainty of evidence on the new Coronavirus was reflected in the policy narratives in the second compared to the first shutdown. While there is increased use of scientific evidence in the second shutdown stage, this does not reflect an increased evidence base: The evolving use of evidence in policy narratives is mainly reflected in its strategic uses to support a certain policy solution within a blame‐avoidance strategy.
Nonparametric plug‐in classifier for multiclass classification of S.D.E. paths
Authors: Denis Christophe , Dion‐Blanc Charlotte , Ella‐Mintsa Eddy , Tran Viet Chi 
Published: January 2024

AbstractWe study the multiclass classification problem where the features come from a mixture of time‐homogeneous diffusions. Specifically, the classes are discriminated by their drift functions while the diffusion coefficient is common to all classes and unknown. In this framework, we build a plug‐in classifier which relies on nonparametric estimators of the drift and diffusion functions. We first establish the consistency of our classification procedure under mild assumptions and then provide rates of convergence under different set of assumptions. Finally, a numerical study supports our theoretical findings.
Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation
Authors: Diamanti Tamara , Trobiani Laura , Mautone Lorenza , Serafini Federica , Gioia Roberta , Ferrucci Laura , Lauro Clotilde , Bianchi Sara , Perfetto Camilla , Guglielmo Stefano , Sollazzo Raimondo , Giorda Ezio , Setini Andrea , Ragozzino Davide , Miranda Elena , Comoletti Davide , Di Angelantonio Silvia , Cacci Emanuele , De Jaco Antonella 
Published: January 2024

AbstractNeuroligins are synaptic cell adhesion proteins with a role in synaptic function, implicated in neurodevelopmental disorders. The autism spectrum disorder‐associated substitution Arg451Cys (R451C) in NLGN3 promotes a partial misfolding of the extracellular domain of the protein leading to retention in the endoplasmic reticulum (ER) and the induction of the unfolded protein response (UPR). The reduced trafficking of R451C NLGN3 to the cell surface leads to altered synaptic function and social behavior. A screening in HEK‐293 cells overexpressing NLGN3 of 2662 compounds (FDA‐approved small molecule drug library), led to the identification of several glucocorticoids such as alclometasone dipropionate, desonide, prednisolone sodium phosphate, and dexamethasone (DEX), with the ability to favor the exit of full‐length R451C NLGN3 from the ER. DEX improved the stability of R451C NLGN3 and trafficking to the cell surface, reduced the activation of the UPR, and increased the formation of artificial synapses between HEK‐293 and hippocampal primary neurons. The effect of DEX was validated on a novel model system represented by neural stem progenitor cells and differentiated neurons derived from the R451C NLGN3 knock‐in mouse, expressing the endogenous protein. This work shows a potential rescue strategy for an autism‐linked mutation affecting cell surface trafficking of a synaptic protein.
An Inquiry-Based Learning Module for General Mathematics: Its’ Development and Evaluation
Authors: Lumabit April Mae C. , Sagge, Jr. Roberto G. 
Published: January 2024

The goal of this developmental research was to develop and evaluate an Inquiry-Based Learning Module for General Mathematics for Grade 11 students. It was conducted at two secondary schools with one hundred forty-one Grade 11 students and four mathematics teachers as respondents. The study used the descriptive-evaluative method to describe and evaluate the developed module using the questionnaire-checklist in gathering data. The development of the module utilized the modified model by Borg and Gall, which includes the inspection of the curriculum guide, planning, product development and designing assessment instrument, development of the instructional materials, validation of mathematics teachers and experts, revisions, limited trial to students and the finalization of the instructional material. The respondents were asked to evaluate the worktext on the following aspects: objectives, contents, activities, style and presentation, organization, creativity, and assessment. The result shows that the developed module with respect to objectives, contents, activities, style and presentation, organization, creativity, and assessment was verbally interpreted as "very good". Generally, the respondents evaluated the developed module as "very good". This means that the developed module very satisfactorily meets the standards with very few revisions. Thus, the researcher recommends the use of the developed inquiry-based learning module for General Mathematics for Grade 11 teachers and students to facilitate teaching and learning.
Confronting Loneliness with Devotion
Authors: Metzger Gaudenz Urs 
Published: January 2024

Abstract
Today, the practice of religion is strongly influenced by digitalisation, in not only everyday life but also liminal situations such as dying. Apps, social networks, and virtual church services offer believers opportunities for participation when their mobility is impaired due to ageing and severe illness. This short-term ethnography explores Bible (e-)reading and (religious) encounters in a palliative care unit of a Swiss hospital, drawing on in-depth interviews, participant observation, and documentary photography. Using the case of a devout Protestant, who was chosen as a case study from a sample of 12 terminally ill patients, I will investigate 1) the existential issues involved in the dying process, 2) how Bible (e-)reading alleviates these issues, and 3) the networks and encounters with which the practice is connected. The results show that anticipation of death in conjunction with personality and social issues bestow a complex emotional tone on the Christian’s end-of-life journey. Bible reading, performed both through mobile mediation and face-to-face with companions, is an avenue through which to gain strength and hope in this difficult situation. Another important finding is that the devotional practice involves an exchange of gifts, which transposes the practice into a moral economy of compassion and care.
Islam during the Time of Pandemics: Islamic Arab Scholars’ Framing of covid-19
Authors: Galal Ehab 
Published: January 2024

Abstract
In the Arab countries, restrictions on events and gatherings due to covid-19 have as elsewhere affected religious practices. Mosques and churches have been closed temporarily and religious authorities have taken part in public discussions about the meaning and way of dealing with covid-19. In this context, the article explores the interaction between state and religion by analysing the arguments used by Muslim authorities to legitimize or challenge the Arab states’ politics towards covid-19 in the spring 2020. The scientific and secular arguments of the states are met by three positionings among Muslim authorities: Those who based on religious dogma agree with and confirm the states’ approach to covid-19; those who argue that religion gives all the answers; and those who discard and distrust the states’ motives and dealings. Accordingly, handling the covid-19 in the Arab countries repeats frequent positions in the continuing discussion on religion in Arab societies.
“You Can’t Fight What’s Already Happening, Right?”: A Case Study of Christian Live-Streaming
Authors: Anderson LaRisa Denise 
Published: January 2024

Abstract
Since the onset of covid-19, live-stream has become a popular addition to contemporary church technologies. This case study includes interviews with six church leaders representing two churches of varying sizes, demographics, and resources in Austin, Texas, in 2019. This study applies Heidi Campbell (2010)’s Religious-Social Shaping of Technology (rsst) framework to the operationalization of community on live-stream compared to physical gatherings. Interview data and observational field notes were thematically analyzed following the four tenets of rsst. Findings show both churches use live-stream to serve three self-identified audiences: (1) members with accessibility needs, (2) the unchurched who need an introduction to Christianity, and (3) an imagined community of “burned” ex-churchgoers who still desire connection. Live-stream was unilaterally deployed to (1) meet people where they are, (2) promote healthy discourse, and (3) expand the church. Implications for deploying technology in churches without critically examining affordances, disconnection, and organizational mission are discussed.
Reinterpretation of Social Media as Resource for Ministry and Missionary Work
Authors: Grishaeva Ekaterina I. , Shumkova Valeria A. 
Published: January 2024

Abstract
Previous studies have primarily analysed religious media practitioners (rmp s) as authoritative figures who either challenge or project online traditional religious authorities. However, the routinised internet becomes more of a resource used by rmp s to communicate religious message. Given this, our study focuses on rmp s agency manifestation when they mobilize the internet as a resource. We conceptualize agency as related to structure (Sewell, 1992) and unfolding across time (Emirbayer and Mische, 1998). Our analysis is based on two cases from the Russian Orthodox Church. We argue that religious socialization (internalized schemas and access to resources) empowers rmp s agency and shapes the format of media project (traditionalist ministry or modernist missionary work). It affects the way rmp s ‘manoeuvre’ between Orthodox and media schemas while working on social media – they either reproduce the bounded community space or stimulate open discussions. In both cases rmp s’ knowledge endows them with certain power over hierarchy.
Fit and Viable Determinants of Gamification in Christian Religious Studies in Developing Economy Context
Authors: Akuetteh Alfred Patterson , Kolog Emmanuel Awuni , Boateng Richard , Egala Sulemana Bankuoru 
Published: January 2024

Abstract
Gamification has been utilized in bible applications for religious learning activities to create excitement and encourage positive behavioral outcomes. However, there is a noticeable gap in the effectiveness and viability of gamified bible applications, particularly among Ghanaian Christian faiths. In this study, we explored the fit and viability of gamification in Christian religious studies. Based on the Fit-Viability Theory, we analyzed data from 432 respondents from various Christian denominations in Ghana using structural equation modelling. Our findings revealed that Task and Technology Characteristics, Economic, Organizational, and individual Christian Doctrines significantly influence the adoption and use of gamified Bible applications in a developing country context.
Multicultural and Intercultural Education in Hong Kong: Insights from a Minority-Majority Secondary School
Authors: Ma Peicong , Bhowmik Miron , Lin Jason Cong , Jackson Liz 
Published: January 2024

Abstract
This case study explored how the principles of multicultural and intercultural education are reflected in a minority-majority Hong Kong secondary school (that is, a school where most students are ethnic minorities). The findings suggest that the school illustrates several aspects of multicultural and intercultural education, especially content integration, prejudice reduction, equity pedagogy, and democratic deliberation, particularly in relation to school-based material, teacher sensitivity, and dialogical reasoning. The main hurdles discovered are language learning difficulties and an unsupportive social environment. This study contributes to literature on the development of multicultural and intercultural education in Hong Kong and offers directions for generalizable future research.
Experimental and density functional theory studies on some metal oxides and the derived nanoclusters: a comparative effects on human ferritin
Authors: Al-Garawi Zahraa S. , Ismail Ahmad H. , Hillo Duaa H. , Öztürkkan Füreya Elif , Necefoğlu Hacali , Mohamed Gehad G. , Abdallah Abanoub Mosaad 
Published: January 2024

AbstractA comprehensive investigation into the green synthesis of metal oxide nanoparticles (NPs) has garnered significant attention due to its commendable reliability, sustainability, and environmentally friendly attributes. Green synthesis methods play a crucial role in mitigating the adverse effects associated with conventional approaches employed for nanostructure preparation. This research endeavors to examine the impact of ginger plant extract-assisted green synthesis of metal oxides NPs on the serum ferritin levels of anemic diabetic patients in vitro, focusing specifically on α-Fe2O3 and ZnO NPs. Sixty diabetic volunteers with anemia (35–50 years) and thirty healthy volunteers were enrolled as controls. The assessment was conducted using the VIDAS Ferritin (FER) assay. Photoluminescence (PL) spectroscopy measurements were performed to elucidate the intrinsic and extrinsic transitions of these NPs, affirming the successful formation of α-structured iron oxide. Density functional theory (DFT) calculations were carried out at the B3LYP/6-311++G(d,2p) level of theory to investigate the geometry optimization and molecular electrostatic potential maps of the NPs. Furthermore, TD-DFT calculations were employed to explore their frontier molecular orbitals and various quantum chemical parameters. The binding affinity and interaction types of ZnO and α-Fe2O3 NPs to the active site of the human H-Chain Ferritin (PDB ID: 2FHA) target were determined with the help of molecular docking. Results unveiled the crystalline structure of ZnO and the α-structure of α-Fe2O3. Analysis of the frontier molecular orbitals and dipole moment values demonstrated that ZnO (total dipole moment (D) = 5.80 µ) exhibited superior chemical reactivity, biological activity, and stronger molecular interactions with diverse force fields compared to α-Fe2O3 (D = 2.65 µ). Molecular docking of the metal oxides NPs with human H-chain ferritin provided evidence of robust hydrogen bond interactions and metal-acceptor bonds between the metal oxides and the target protein. This finding could have a great impact on using metal oxides NPs-ferritin as a therapeutic protein, however, further studies on their toxicity are required.
Graphical abstract
Cellograph: a semi-supervised approach to analyzing multi-condition single-cell RNA-sequencing data using graph neural networks
Authors: Shahir Jamshaid A. , Stanley Natalie , Purvis Jeremy E. 
Published: January 2024

AbstractWith the growing number of single-cell datasets collected under more complex experimental conditions, there is an opportunity to leverage single-cell variability to reveal deeper insights into how cells respond to perturbations. Many existing approaches rely on discretizing the data into clusters for differential gene expression (DGE), effectively ironing out any information unveiled by the single-cell variability across cell-types. In addition, DGE often assumes a statistical distribution that, if erroneous, can lead to false positive differentially expressed genes. Here, we present Cellograph: a semi-supervised framework that uses graph neural networks to quantify the effects of perturbations at single-cell granularity. Cellograph not only measures how prototypical cells are of each condition but also learns a latent space that is amenable to interpretable data visualization and clustering. The learned gene weight matrix from training reveals pertinent genes driving the differences between conditions. We demonstrate the utility of our approach on publicly-available datasets including cancer drug therapy, stem cell reprogramming, and organoid differentiation. Cellograph outperforms existing methods for quantifying the effects of experimental perturbations and offers a novel framework to analyze single-cell data using deep learning.
Comparative physiological and transcriptome analysis between potassium-deficiency tolerant and sensitive sweetpotato genotypes in response to potassium-deficiency stress
Authors: Jin Rong , Yan Mengxiao , Li Guanghua , Liu Ming , Zhao Peng , Zhang Zhe , Zhang Qiangqiang , Zhu Xiaoya , Wang Jing , Yu Yongchao , Zhang Aijun , Yang Jun , Tang Zhonghou 
Published: January 2024

Abstract
Background
Sweetpotato is a typical ‘‘potassium (K+) favoring’’ food crop, which root differentiation process needs a large supply of potassium fertilizer and determine the final root yield. To further understand the regulatory network of the response to low potassium stress, here we analyze physiological and biochemical characteristics, and investigated root transcriptional changes in two sweetpotato genotypes, namely, - K tolerant “Xu32” and - K susceptible“NZ1”.

Result
We found Xu32 had the higher capability of K+ absorption than NZ1 with better growth performance, higher net photosynthetic rate and higher chlorophyll contents under low potassium stress, and identified 889 differentially expressed genes (DEGs) in Xu32, 634 DEGs in NZ1, 256 common DEGs in both Xu32 and NZ1. The Gene Ontology (GO) term in molecular function enrichment analysis revealed that the DEGs under low K+ stress are predominately involved in catalytic activity, binding, transporter activity and antioxidant activity. Moreover, the more numbers of identified DEGs in Xu32 than that in NZ1 responded to K+-deficiency belong to the process of photosynthesis, carbohydrate metabolism, ion transport, hormone signaling, stress-related and antioxidant system may result in different ability to K+-deficiency tolerance. The unique genes in Xu32 may make a great contribution to enhance low K+ tolerance, and provide useful information for the molecular regulation mechanism of K+-deficiency tolerance in sweetpotato.

Conclusions
The common and distinct expression pattern between the two sweetpotato genotypes illuminate a complex mechanism response to low potassium exist in sweetpotato. The study provides some candidate genes, which can be used in sweetpotato breeding program for improving low potassium stress tolerance.