bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular structure, spectroscopy, molecular docking, and molecular dynamic studies of tetrahydroneoprzewaquinone as potent cervical cancer agent
Authors: Owen Aniekan E. , Agwamba Ernest C. , Gideon Mathias E. , Chukwuemeka Kelechi , Ejiofor Emmanuel U. , Benjamin Innocent , Ahukwe Eze F. , Ogungbemiro Festus O. , Maxwell Kube T. , Manicum Amanda-Lee E. , Louis Hitler 
Published: December 2023

AbstractCervical cancer is one of the most prevalent cancer-related diseases, causing accelerated morbidity and mortality rates in low-income countries and African states. This study explores the potential of (3R,3′R)-2,2′,3,3′-tetrahydroneoprzewaquinone (TDN) as a treatment for cervical cancer by investigating its structural and molecular properties using molecular modelling technique, which include; DFT, molecular docking, molecular dynamic simulation. The results are promising, with TDN demonstrating exceptional stability in the energy gap (Eg) as well as through natural bond order analysis (NBO). π → σ* electronic transitions were found to contribute mainly to the molecule’s stability, with an outstanding total stabilization energy (E(2)). Docking exercises showed that TDN binds more favorably to the pro-apoptotic receptor 4s0o with a stronger H-bond compared to the conventional DOX drug, which interacted less effectively with TDN and more strongly with the anti-apoptotic protein, forming an outstanding strong H-bond. Molecular dynamics simulations also revealed that TDNʼs interaction with the pro-apoptotic protein (TDN_4S0o) was more stable than the standard DOX drug (DOX_4s0o). The H-bond plot indicated that TDN could effectively interact with both anti and pro-apoptotic receptors, forming approximately 1 to 4 hydrogen bonds between TDN_1g5M with respect to each picosecond (ps) ranging from 0 to 1000 ps. In contrast, the number of hydrogen bonds fluctuated when DOX interacted with the anti-apoptotic protein (1g5M), ranging from 1 to 5 H-bonds. Overall, these results suggest that TDN may be a promising drug candidate for cervical cancer treatment.
Part 1: Evaluating Neck-Strengthening Protocols to Reduce the Incidence of Traumatic Brain Injury: Traditional vs. Nontraditional Neck-Strengthening Techniques
Authors: Schroeder Lindsey H. , McDaniel Alexander T. , Wang Yishi , Dickens Gabe M. , Pantani Valentina , Kubinak Haley 
Published: December 2023

Abstract
Schroeder, LH, McDaniel, AT, Wang, Y, Dickens, GM, Pantani, V, and Kubinak, H. Part 1: evaluating neck-strengthening protocols to reduce the incidence of traumatic brain injury: traditional vs. nontraditional neck-strengthening techniques. J Strength Cond Res 38(1): 21–29, 2024—A common cause of traumatic brain injuries (TBIs) is the head's kinematic response to rapid movement, which can be reduced with dynamic neck strengthening. This study aimed to determine the most effective neck-strengthening program by comparing a traditional and nontraditional program. Isometric neck strength was assessed in 32 subjects randomly assigned to one of the traditional and nontraditional neck-strengthening programs. The nontraditional program used a novel neck-strengthening device. After weeks 6 and 10 of training, isometric neck strength was reassessed. With the collected data, linear mixed models were established to compare the changes in neck strength between the 2 groups during the 10-week training period. Statistical analysis results suggest that, for both cervical extension (CE) and cervical flexion (CF), subjects in the novel neck-strengthening device group had a significantly higher gain of strength during the 10 weeks than the traditional group. With test statistics of −2.691 and −3.203 and corresponding 2-sided p-value of 0.01289 and 0.003889, respectively, we conclude that there is a statistically significant difference in the linear slopes of increase for both CE and CF between the 2 groups. As to left cervical lateral flexion and right cervical lateral flexion, the novel neck strength group had increased strength gains compared with the traditional group. However, the increase was not enough to demonstrate significant findings. Results were considered significant at p < 0.05. The results of this study show that the novel neck-strengthening device may be an effective mechanism for preventing mild TBIs.
Exercise Intensity Progressions and Criteria to Prescribe Core Stability Exercises in Young Physically Active Men: A Smartphone Accelerometer-Based Study
Authors: Heredia-Elvar Juan R. , Juan-Recio Casto , Prat-Luri Amaya , Barbado David , de los Ríos-Calonge Javier , Vera-Garcia Francisco J. 
Published: December 2023

Abstract
Heredia-Elvar, JR, Juan-Recio, C, Prat-Luri, A, Barbado, D, Ríos-Calonge, Jdl, and Vera-Garcia, FJ. Exercise intensity progressions and criteria to prescribe core stability exercises in young physically active men: a smartphone accelerometer-based study. J Strength Cond Res 38(2): 266–273, 2024—The establishment of core stability (CS) exercise intensity progressions in sport and clinical settings is normally based on subjective criteria. Therefore, this study aimed to develop exercise intensity progressions for some of the most common CS exercises through smartphone accelerometry and to analyze the effect of the subjects' lumbopelvic postural control on these progressions. Fifty-seven healthy young physically active male students performed 7 isometric variations of front bridge, back bridge, side bridge, and bird-dog exercises with a smartphone accelerometer placed on the pelvis. Mean pelvic accelerations were calculated during each variation to evaluate the lumbopelvic postural control challenge imposed on the subjects as an index of exercise intensity of difficulty. For the bridge exercises, long bridging produced higher pelvic accelerations than short bridging, bridging with single-leg support was more intense than bridging with double-leg support (even with both legs on a hemisphere ball for the back and front bridge), and the most difficult variations were those performed on a Swiss ball, mainly the variations with single-leg support. For the bird-dog exercise, the 2-point positions were more intense than the 3-point positions, the variations performed with a knee on the hemisphere ball produced higher pelvic accelerations than similar variations performed with the forearm on the hemisphere ball, and the variations with limb motions generated higher pelvic accelerations than similar variations performed without limb motions. Although the CS exercise progressions were very similar across subjects, our results showed the need to individualize the prescription of the CS exercise progressions based on the subjects' lumbopelvic postural control level.
Modeling the Early and Late Acceleration Phases of the Sprint Start in Elite Long Track Speed Skaters
Authors: Zukowski Matthew H. , Herzog Walter , Jordan Matthew J. 
Published: December 2023

Abstract
Zukowski, MH, Jordan, MJ, and Herzog, W. Modeling the early and late cceleration phases of the sprint start in elite long track speed skaters. J Strength Cond Res 38(2): 236–244, 2024—This study established the reliability of an exponential function to model the change in velocity during the speed skating sprint start and the validity of associated model parameters in a group of subelite and elite long track speed skaters. Long track speed skaters (n = 38) performed maximal effort 50-m on-ice accelerations from a standing start while tethered to a horizontal robotic resistance device that sampled position and time data continuously. An exponential function was applied to the raw data to model the change in velocity throughout the acceleration phase and compute the maximal skating speed (MSS), maximal acceleration capacity (MAC), maximum relative net horizontal power (P
Max), and an acceleration-time constant (τ). All constructed models provided a sufficient fit of the raw data (R-squared > 0.95, mean bias <2%). Intraday reliability of all model parameters ranged from good to excellent (intraclass correlation coefficient >0.8 and coefficient of variation <5%). Strong negative correlations (r: −0.72 to −0.96) were observed between MSS and P
Max and the 10 and 20 m split times measured with the robotic resistance and with 100 split times obtained from 500 m races. Moderate-to-large between-group differences were observed in MSS, MAC, and P
Max between the elite vs. subelite speed skaters (Cohen d effect sizes: 1.18–3.53). Our results indicate that monoexponential modeling is a valid and reliable method of monitoring initial acceleration performance in elite level long track speed skaters.
Differences in Lift Quality During the Barbell Back Squat When Using Perceived Recovery Status–Regulated Intrasession Recovery Compared With Standardized Recovery Intervals
Authors: Wolfe Andy A. , Laurent Charles M. , Tolusso Danilo V. , Rinehart Aaron N. 
Published: December 2023

Abstract
Wolfe, AA, Laurent, CM, Tolusso, DV, and Rinehart, AN. Differences in lift quality during the barbell back squat when using perceived recovery status–regulated intrasession recovery compared with standardized recovery intervals. J Strength Cond Res XX(X): 000–000, 2023—The current investigation examined kinetic differences between standardized and perceptually regulated rest internals during power-based resistance training. Recreationally resistance-trained men (n = 7) and women (n = 7) completed 3 training sessions. Session 1 consisted of barbell back squat (SQ) 1 repetition maximum (1RM) testing. Two counterbalanced subsequent sessions of perceptually regulated vs. standardized intrasession recovery for 5 sets of 6 repetitions of SQ at 80% 1RM were completed. Lift quality was assessed using a barbell accelerometer that measured concentric and eccentric power and force outputs for each repetition. In each set, subjects reported a rating of perceived exertion (RPE) followed by passive rest for either 2 minutes or a self-selected period using the Perceived Recovery Status (PRS) scale. For the self-selected session, when an individual reported a PRS at level “7,” they were instructed to begin the next set. Data were analyzed using a 2 (session) × 5 (set) repeated-measures ANOVA with Bonferroni post hoc analyses performed when appropriate. No significant main effects or interactions were observed for any set quality metrics in the concentric phase or eccentric phase, except peak eccentric power (p = 0.01). Post hoc analyses revealed a significant increase in peak eccentric power from set 1 to set 2 (p = 0.003) only. Finally, no significant difference between self-selected vs. standardized work-to-rest strategies on RPE (p = 0.547) was expressed. These data suggest perceptually regulated intrasession recovery selection yields equivalent lift quality as standardized rest recommendations. Therefore, PRS utilization may provide a more simplified and individualized method of between-set rest prescriptions.
Running Alterations Pre- and Postarthroscopy for Femoroacetabular Impingement Syndrome and Labral Tears
Authors: Freemyer Bret , Beeler Derek , Crawford Scott , Durkin Robert , Stickley Christopher 
Published: December 2023

Abstract
Freemyer, B, Beeler, D, Crawford, S, Durkin, R, and Stickley, C. Running alterations pre- and postarthroscopy for femoroacetabular impingement syndrome and labral tears. J Strength Cond Res XX(X): 000–000, 2023—Running is essential to sports participation and activity over the lifespan; however, running biomechanics are not fully described in patients with femoroacetabular impingement (FAIS). The purpose was to compare FAIS patient report outcome surveys (PRO) and running biomechanics preoperatively and 6 months postoperatively with controls. Nineteen subjects (FAIS, n = 10 and age-matched controls, n = 9) were included. The UCLA, Hip Outcome Score activity of daily living (HOSADL) and sports subscale (HOSSS), and 3-D running biomechanics were evaluated. Statistical parametric mapping was conducted on biomechanics data. Statistical significance was set at p ≤ 0.05. Femoroacetabular impingement had similar UCLA activity scores compared with controls by 6 months (FAIS: 8.4 ± 1.7, CON: 8.6 ± 2.0, p = 0.80), despite lower HOSADL (FAIS-Six: 89.3 ± 6.3, CON: 100 ± 0, p = 0.04) and HOSSS (FAIS-Six: 82.6 ± 18.5, CON: 100 ± 0, p = 0.05). The FAIS group had lower knee adduction moments (KAM) around 22–27% of stance (p = 0.05) and lower sagittal plane ankle power generation during the final 5% of stance compared with the controls (p = 0.04) preoperatively. The FAIS also had lower vertical ground reaction forces the first 2% of stance (p = 0.05) and lower KAM from 20 to 30% stance (p = 0.03) at the postoperative time vs. controls. Femoroacetabular impingement had higher hip external rotation angles the first 5% stance (p = 0.05) and the last 20% of stance (p = 0.01) vs. controls. This is the first study to describe FAIS running pre- and postoperatively. Despite higher activity and health 6 months postarthroscopy, the patients with FAIS had altered running biomechanics. Clinicians should consider these findings when creating rehabilitation protocols and during running progressions across the postoperative care of patients with FAIS.
Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women
Authors: Chapman-Lopez Tomas J. , Funderburk LesLee K. , Heileson Jeffery L. , Wilburn Dylan T. , Koutakis Panagiotis , Gallucci Andrew R. , Forsse Jeffrey S. 
Published: December 2023

Abstract
Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res XX(X): 000–000, 2023—This study examined the effects of supplementing 5 g of leucine compared with a placebo during a 10-week resistance training program on body composition parameters and adipokine concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five women were randomly assigned to 2 groups—leucine (LEU, n = 17) and placebo (PLC, n = 18)—in a double-blind, placebo-controlled trial. Each group consumed the supplement or placebo every day and completed a resistance training program for 10 weeks. Using 3-day food records, a diet was assessed before the intervention and after its cessation. Body composition was assessed preintervention and postintervention using dual-energy x-ray absorptiometry. Moreover, the concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte chemoattractant protein-1 (MCP-1), were assessed preintervention and postintervention. Both groups showed an increase in visceral adipose tissue (VAT) area (p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant group differences in concentrations of visfatin (p = 0.020) and leptin (p = 0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations in the PLC group and leptin displayed higher concentrations in the LEU group. In addition, there were significant decreases in adiponectin concentrations for both groups (LEU: 652 ± 513 to 292 ± 447 pg·ml−1; PLC: 584 ± 572 to 245 ± 356 pg·ml−1, p = 0.002) and MCP-1 only decreased in the PLC group (253 ± 119 to 206 ± 106 pg·ml−1, p = 0.004). There were significant decreases in adiponectin concentrations in both groups and a decrease in MCP-1 concentrations in the PLC group. These decreases may be due to both adipokines possible relationship with VAT area. However, it is not known whether leucine has underlying properties that hinder changes in MCP-1 concentrations.
Kinematic, Kinetic, and Temporal Metrics Associated With Golf Proficiency
Authors: McHugh Malachy P. , O'Mahoney Catherine A. , Orishimo Karl F. , Kremenic Ian J. , Nicholas Stephen J. 
Published: December 2023

AbstractMcHugh, MP, O’Mahoney, CA, Orishimo, KF, Kremenic, IJ, and Nicholas, SJ. Kinematic, kinetic, and temporal metrics associated with golf proficiency.J Strength Cond ResXX(X): 000–000, 2023—The biomechanics of the golf swing have been studied extensively, but the literature is unclear on which metrics are indicative of proficiency. The purpose of this study was to determine which metrics identified golf proficiency. It was hypothesized that discrete kinematic, kinetic, and temporal metrics would vary depending on proficiency and that combinations of metrics from each category would explain specific proficiency metrics. Kinematic, kinetic, and temporal metrics and their sequencing were collected for shots performed with a driver in 33 male golfers categorized as proficient, average, or unskilled (based on a combination of handicap, ball velocity, and driving distance). Kinematic data were collected with high-speed motion analysis, and ground reaction forces (GRF) were collected from dual force plates. Proficient golfers had greater x-factor at ball impact and greater trunk deceleration before ball impact compared with average (p< 0.05) and unskilled (p< 0.01) golfers. Unskilled golfers had lower x-factor at the top of the back swing and lower peak x-factor, and they took longer to reach peak trunk velocity and peak lead foot GRF compared with average (p< 0.05) and proficient (p< 0.05) golfers. A combination of 2 kinematic metrics (x-factor at ball impact and peak pelvis velocity), 1 kinetic metric (peak lead foot GRF), and 2 timing metrics (the timing of peak trunk and arm velocity) explained 85% of the variability in ball velocity. The finding that x-factor at ball impact and trunk deceleration identified golf proficiency points to the potential for axial trunk rotation training to improve performance.
Acute Effects of Resistance Exercise on Intraocular Pressure in Healthy Adults: A Systematic Review
Authors: Hackett Daniel A. , Li Jiuzhang , Wang Boliang , Way Kimberley L. , Cross Troy , Tran Derek L. 
Published: December 2023

Abstract
Hackett, DA, Li, J, Wang, B, Way, KL, Cross, T, and Tran, DL. Acute effects of resistance exercise on intraocular pressure in healthy adults: A systematic review. J Strength Cond Res 38(2): 394–404, 2024—Intraocular pressure (IOP) tends to fluctuate during a resistance exercise (RE). This systematic review examines the acute effects of RE on IOP in healthy adults and factors that influence changes in IOP. Five electronic databases were searched using terms related to RE and IOP. A strict inclusion criterion was applied, which included being 55 years or younger with no medical conditions and RE intensity needing to be quantifiable (e.g., based on a maximal effort). Thirty-four studies met the inclusion criteria for this review. Isometric and isotonic contractions produced similar changes in IOP during RE up to 28.7 mm Hg. Exercises that involved larger muscle mass, such as squats and leg press, were found to produce changes in IOP during exercise ranging from 3.1 to 28.7 mm Hg. Smaller changes in IOP during RE were found for exercises engaging less muscle mass (e.g., handgrip and bicep curls). Intraocular pressure was found to increase during RE when lifting heavier loads and with longer exercise durations (e.g., greater repetitions). The Valsalva maneuver (VM) and breath-hold during RE accentuated the change in IOP, with more extreme changes observed with the VM. However, most studies showed that postexercise IOP returned to baseline after approximately 1 minute of recovery. An acute increase in IOP is observed during RE in healthy adults with fluctuations of varying magnitude. Factors that independently increase IOP during RE include exercises involving larger muscle mass, heavy loads, greater set duration, and when the VM or breath-hold is performed.
Neuromuscular Responses and Perceptions of Health Status and Pain-Related Constructs in End-Stage Knee Osteoarthritis During Resistance Training With Blood Flow Restriction
Authors: Ogrezeanu Daniel C. , López-Bueno Laura , Sanchís-Sánchez Enrique , Carrasco Juan J. , Cuenca-Martínez Ferran , Suso-Martí Luis , López-Bueno Rubén , Cruz-Montecinos Carlos , Martinez-Valdes Eduardo , Casaña José , Calatayud Joaquín 
Published: December 2023

Abstract
Ogrezeanu, DC, López-Bueno, L, Sanchís-Sánchez, E, Carrasco, JJ, Cuenca-Martínez, F, Suso-Martí, L, López-Bueno, R, Cruz-Montecinos, C, Martinez-Valdes, E, Casaña, J, and Calatayud, J. Neuromuscular responses and perceptions of health status and pain-related constructs in end-stage knee osteoarthritis during resistance training with blood flow restriction. J Strength Cond Res XX(X): 000–000, 2023—We aimed to evaluate the neuromuscular responses and their relationship with health status, kinesiophobia, pain catastrophizing, and chronic pain self-efficacy in patients with end-stage knee osteoarthritis during acute resistance training with different levels of blood flow restriction (BFR). Seventeen patients with end-stage knee osteoarthritis participated in 3 experimental sessions separated by 3 days, performing 4 sets of knee extensions with low load and 3 levels of concurrent BFR performed in a random order: control (no BFR), BFR at 40% arterial occlusion pressure (AOP), and BFR at 80% AOP. Normalized root-mean-square (nRMS), nRMS spatial distribution (centroid displacement, modified entropy, and coefficient of variation), and normalized median frequency (nFmed) were calculated from the vastus medialis (VM) and lateralis (VL) using high-density surface electromyography. Subjects were asked to report adverse effects after the sessions. In the VM, nRMS was higher with 80% AOP than with 40% AOP (p = 0.008) and control (p < 0.001), whereas there were no differences between conditions in the VL. Normalized root-mean-square also showed an association with pain catastrophizing, chronic pain self-efficacy, and health status (VM: −0.50, 0.49, −0.42; VL: −0.39, 0.27, −0.33). Spatial distribution varied between conditions but mostly in the VL. Overall, nFmed did not vary, with only a slight increase in the VL with 40% AOP, between set 3 and 4. BFR during knee extensions at 80% AOP increases VM activity and VL amplitude distribution more than 40% AOP and control. Importantly, muscle activity increases are modulated by pain catastrophizing, chronic pain self-efficacy, and health status in these patients, and kinesiophobia seems to especially modulate entropy.