bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights into tissue-specific responses and interactive characteristics of crop-microbe “One Health” system to soil chromium and ofloxacin pollution
Authors: Xu Jia-Min , Zhang Yaru , Wang Kai , Zhang Guodong , Liu Ying , Xu Hao-Ran , Zi Hu-Yi , Wang Ai-Jie , Cheng Hao-Yi , Lv Yao , Xu Kun 
Published: October 2023

AbstractThis study firstly investigated the tissue-specific responses and interactive characteristics of the crop-microbe system to co-pollution with ofloxacin (OFL) and chromium (Cr) in soil. The results emphasized the hormesis effect induced by low-dose OFL (1 mg L-1) on ginger plants subjected to soil Cr stress. However, high-dose OFL (100 mg L-1) and Cr co-stressed plants exhibited reduced growth, root activity, antioxidant enzyme activities and photosynthesis-fluorescence performances, while the reactive oxygen species (ROS) reflected by O2·-and H2O2significantly increased up to 43.34% and 78.63%, respectively, compared to other treatments. In addition, high-throughput sequencing indicated that OFL influenced rhizosphere microbial diversity, composition, and evolution, favoringProteobacteriaproliferation under co-pollution. Meanwhile, root exudate patterns shifted, with humic-like exudates, potentially interacting with pollutants and microbes. Notably, enrichments of antibiotic resistance gene (qnrS) in edible rhizome and potential pathogenic bacteria in ginger rhizosphere were observed under OFL and Cr co-pollution, raising environmental and food chain concerns. Through structural equation modeling, we quantitatively established correlations within soil-crop-microbe factors, emphasizing their interconnected nature. Overall, this study sheds light on the complex responses of the crop-microbe system to OFL and Cr co-pollution, highlighting the importance of understanding pollutant interactions for enhancing plant resilience and mitigating environmental risks.HighlightsRevealed a hormesis from low-dose OFL on Cr-polluted ginger, enhancing resilience.Rhizosphere microbial composition shift under co-pollution, favoring Proteobacteria.qnrS and potential pathogens increased under co-pollution, posing food chain risks.Structural equation modeling quantified correlations in soil- crop-microbe factors.Clarified crop-microbe “One Health” interactions’ role under Cr & OFL co-pollution.Graphical abstract
Ependymocytes control cerebrospinal fluid flow to the peripheral organs through periaxonal pathway
Authors: Li Xinyu , Wang Siman , Zhang Dianjun , Feng Yuliang , Liu Yingyu , Yu Weiyang , Li Shu , Cui Lulu , Harkany Tibor , Verkhratsky Alexei , Xia Maosheng , Li Baoman 
Published: October 2023

SummaryMechanisms controlling movement of the CSF through the central canal towards the peripheral nerves are poorly characterized. We found that fluorescent dyes injected into cisterna magna are carried with cerebrospinal fluid (CSF) through the central canal and peripheral nerves to the peripheral organs such as liver, and pancreas. We also found close connection between spinal axons and ependymocytes, suggesting synaptic interactions. Serotonin, acting through the 5-HT2Breceptors abundantly expressed in ependymal cells, trigger Ca2+signal that induces polymerization of cytoskeleton protein F-actin, consequently reducing the volume of ependymocytes. Shrinkage of the latter opens one-way route to facilitate CSF outflow from the central canal into the spinal cord parenchyma and peripheral nerves. In liver, CSF is received by stellate cells. Ependymal control over transfer of the CSF from central canal to peripheral organs by the periaxonal space (PAS) represents a novel mechanism dynamically connecting the CNS with the periphery.In briefEpendymocytes control CSF flow from CNS to peripheral organs by periaxonal pathway, and serotonin evokes the ependymal shrinkage by the aggregation of F-actin.HighlightsEpendymocytes control CSF flow from central canal to peripheral organs; CSF flows through the peripheral periaxonal space to reach the peripheral organs; Serotonin makes ependymocytes shrunk by 5-HT2Breceptor-mediated Ca2+signaling and F-actin polymerization; The hepatic stellate cells are potential collectors of CSF in the liver.
Business environment and productivity in Africa: macro evidence
Authors: Haruna Issahaku , Ackah Charles Godfred 
Published: October 2023

PurposeAfrica's business environment (BE) is characteristically unfriendly and poses severe development challenges. This study evaluates the impact of business climate on productivity in sub-Saharan Africa (SSA).Design/methodology/approachMacroeconomic data for 51 sub-Saharan African economies from 1990 to 2018 are employed for the analysis. The seemingly unrelated regression model is used to address inter-sectorial linkages.FindingsThe study uncovers several findings. First, a high start-up cost substantially leads to productivity losses by limiting the funds available for investment in productivity-enhancing labour and technology and limiting the number of businesses that see the light of day. The productivity impacts of start-up costs are most enormous for industry, followed by services and agriculture. Second, economies with favourable financing environments tend to be more productive economy wide and sector wise. Third, high taxes and tax inefficiency lower productivity by reducing the resource envelope of firms, thus lowering investment amounts. Fourth, poor business infrastructure inflicts the most damage on productivity. Lastly, business administration and macroeconomic environments impact sectoral and economy-wide productivity.Practical implicationsSSA economies must strive to lower the cost of starting a business as high start-up costs injure productivity. One way of reducing start-up costs is to create a one-stop shop for registering and formalising a business. Another way is to automate business registration and administrative processes to reduce red tape and corruption.Originality/valueThe authors extend the body of knowledge by analysing sectoral and economy-wide productivity effects of various business climate indicators while accounting for inter-sectoral linkages, cross-sectional dependence and endogeneity.
Resource orchestration capability for innovation: towards an empirically validated measurement framework
Authors: Tikas Gaurav Dilip 
Published: October 2023

PurposeThe purpose of this research is to conceptualize, define and measure resource orchestration capabilities of R&D teams pursuing advanced scientific research and technological innovation at public-funded R&D organizations in India.Design/methodology/approachA series of five mutually exclusive studies were designed over two years to develop and validate the ROCI scale within public research and development (R&D) organizations pursuing advanced scientific research and technological development in India. The first three studies address the refinement, reduction and rationalization of items for measuring the ROCI construct. The next study explores the factor structure underlying the ROCI construct whereas the subsequent one confirms the three-factor structure within empirical settings.FindingsThe resource orchestration capability towards innovation (ROCI) construct reflected through three sub-dimensions namely – adaptive structuring capability (ASC), synergistic leveraging capability (SLC) and decentralized decision-making capability (DDC), each loaded with their respective items can be used for capability measurement in public-funded R&D organizations.Practical implicationsR&D managers can use this ROCI scale to measure, monitor and improve the innovation-oriented resource orchestration capabilities of their R&D teams and help them improve their innovation performance.Originality/valueThis research contributes to the extant literature on resource orchestration for innovation management in three unique and original ways – theoretically-grounded conceptualization, empirical measurement and rigorous validation through multiple studies conducted in public-funded R&D organizations in India.
Organizational theory – a three-dimensional tool to analyze and enhance collaboration in healthcare systems
Authors: Kaundinya Kiran Bharatam 
Published: October 2023

PurposeHealthcare systems receive criticism from both providers and recipients. The diversity in these systems throughout the world makes innovation and change difficult. However, a structured analysis of healthcare systems is crucial to identify areas for improvement and to share best practices for the betterment of healthcare throughout the world.Design/methodology/approachThe paper uses organizational theory as an unbiased tool for evaluating healthcare systems. This theory analyses healthcare systems across five dimensions: environment, culture, social structure, physical structure and technology. This analysis provides an in-depth understanding of the organization's surroundings, formation and function. It offers a lens through which healthcare systems can be envisioned and establishes a vocabulary for communication.FindingsOrganizational theory presents a multifaceted approach to initiate assessments aiming to enhance existing healthcare systems and customize them to serve all stakeholders within the focused ecosystem. It alters the dynamics of criticism and presents an opportunity to sustainably address unforeseen healthcare challenges in the future. As the author proceeds to understand healthcare organizations through the perspective of organizational theory, the author also uncovers subtle yet crucial issues such as resource dependence, cultural clashes, organizational silence, bureaucracy, hierarchy, ethics, values, engagement and burnout.Originality/valueThis paper was crafted from a collaborative paper for the final of a master's degree. A collaboration was conceptualized using organisation theory as the tool to align processes and achieve successful outcome. The narrative of the collaboration has been edited and paper presented highlighting the importance of the tool of organisation theory in healthcare systems.
Conservation agriculture‐based sustainable intensification improves technical efficiency in Northern Bangladesh: The case of Rangpur
Authors: Paz Bruno , Hailu Atakelty , Rola‐Rubzen Maria Fay , Rashid Md Mamunur 
Published: October 2023

AbstractThe dissemination of conservation agriculture (CA) technologies has become the objective of a growing number of projects aimed at reducing food insecurity in vulnerable areas of the world. While many studies have found that CA increases farm productivity, little is known about the components of the productivity gains related to CA adoption. CA is a knowledge‐intensive technology, and it is expected to affect both technical efficiency (TE) and input productivity positively. Using cross‐sectional farm‐level data of 220 maize farmers in Bangladesh, we measure the impact of CA on farmers' TE. We first apply propensity score matching (PSM) to create comparable counterfactual groups of CA and non‐CA farmers. Then, we use a stochastic frontier with correction for self‐selection bias to analyse TE. Finally, we fit a stochastic meta‐frontier (SMF) model to the data and use it to compare TE across the two farmer groups. The analysis showed that CA farmers exhibit greater TE levels than non‐CA farmers. This can be attributed to enhancements in farm management, leading to 8% and 9% increases in their productivity and TE, respectively. Thus, there is a case for policymakers to strengthen programs delivering CA technologies that improve food security in Bangladesh.
Watermelon (Citrullus lanatus) rind flour: Development and characterization of a novel watermelon byproduct
Authors: Pires Caroline Abreu , de Oliveira Cavalcante Letícia São Paulo , de Carvalho Allan Alexandre Martins , de Siqueira Paula Azevedo , dos Santos Guilherme Vargas , de Paiva Anciens Ramos Gustavo Luis , Matoso Souto Renata Nascimento , de Barros Pinto Moreira Rodrigo Vilela , Teodoro Anderson Junger , Conte Junior Carlos Adam , Cadena Rafael , Domingues Josiane Roberto 
Published: October 2023

AbstractWatermelon (Citrullus lanatus) is a fruit widely consumed by the Brazilian population; however, its rind is usually discarded, despite its nutritional value. This work aimed to develop a watermelon rind flour (WRF) and a fiber‐rich bread. The WRF was submitted to microbiological analysis, proximate composition, antioxidant activity, and a profile of phenolic compounds. Six types of bread were developed: three using WRF (20%, 30%, and 40% of wheat flour replacement) and three control samples (only wheat flour), which were submitted to the same analysis, in addition to colorimetric properties, instrumental texture profile, and sensory evaluation (check‐all‐that‐apply, purchase intent, and acceptance test). A high fiber content was observed in WRF (27.15%). The total concentration of phenolic compounds was 2.38 ± 0.20 mg of gallic acid equivalent per g and benzoic acid was the main compound found (73.50 mg/100 g WRF). The results of the antioxidant capacity through the DPPH method indicated a 30% reduction. The WRF 40% bread had 3.06 g of insoluble fiber, characterizing itself as a source of fiber. In the instrumental texture analysis, it was observed that bread hardness increased significantly as the WRF content increased. The formulation of the bread containing WRF is an alternative for the use of waste, favoring the development of a fiber‐source product, with a functional food claim.
Thrombotic microangiopathy in a patient with anti‐signal recognition particle antibody‐positive immune‐mediated necrotizing myopathy
Authors: Sakai Kenji , Takahashi Megumi , Ito Yumi , Yamada Shota , Ito Toru , Higuchi Yo , Kameda Shigemi 
Published: October 2023

AbstractWe describe the case of a 61‐year‐old woman with anti‐signal recognition particle (SRP) antibody‐positive immune‐mediated necrotizing myopathy (IMNM) who exhibited biopsy‐confirmed thrombotic microangiopathy (TMA). The patient developed proximal‐dominant muscle weakness and was diagnosed with anti‐SRP antibody‐positive IMNM based on muscle biopsy results and serological examination. A high‐dose corticosteroid prescription was initiated, followed by intravenous methylprednisolone and intravenous immunoglobulin therapy (IVIg). The patient showed IVIg‐induced hemolytic anemia with preserved ADAMTS13 activity. Transient oral tacrolimus administration was initiated. Approximately 8 weeks after admission, the serum creatinine levels gradually increased. Renal histological examination revealed TMA, including ischemic changes in the renal tubules, stenosis, and occlusion of the interlobular arteries with fibrinoid necrosis of the afferent arteriolar walls. The arteriolar walls demonstrated an accumulation of C1q and C3c. Myofiber damage in patients with IMNM accounts for the activation of the classical pathway of the complement cascade in the sarcolemma due to antibody deposition. Additionally, a membrane attack complex is observed on capillaries in the muscle tissues of patients with anti‐SRP antibody‐positive IMNM. Although drug‐induced pathomechanisms, such as IVIg and tacrolimus, can trigger the development of TMA, we suggest that the presence of serum anti‐SRP antibodies would be implicated in complement‐associated kidney vascular damage.
Editorial: Time to consider early treatment for chronic hepatitis B in both children and adults—authors' reply
Authors: Wu Xiaoli , Peng Songxu 
Published: October 2023

LINKED CONTENTThis article is linked to Wu et al papers. To view these articles, visithttps://doi.org/10.1111/apt.17667andhttps://doi.org/10.1111/apt.17679
Letter: Detecting unreported alcohol consumption in patients with NAFLD — Standardisation is urgent. Authors' reply
Authors: Lefere Sander , Geerts Anja 
Published: October 2023

LINKED CONTENTThis article is linked to Magherman et al papers. To view these articles, visit https://doi.org/10.1111/apt.17388 and https://doi.org/10.1111/apt.17723
Adhesive organs with complex neuromuscular system: Organization of rhopalioids in Haliclystus auricula James‐Clark, 1863 (Cnidaria: Staurozoa)
Authors: Domracheva Maria , Khabibulina Valeriia 
Published: October 2023

AbstractStaurozoa is a small group of marine stalked jellyfish, some of which have specialized attachment organs — rhopalioids, or so‐called anchors. The adhesive function of these organs was mentioned in numerous studies; however, the mechanism of their temporary attachment is still unknown. Moreover, it is assumed that rhopalioids may be homologous to rhopalia of scypho‐ and cubozoans and provide sensory and integrative functions. Nevertheless, nervous elements associated with rhopalioids are poorly investigated. Thus, we focused on morphological features of rhopalioids in staurozoan Haliclystus auricula James‐Clark, 1863 using histological and semithin sections, and also confocal laser scanning microscopy. We described histological organization of rhopalioids and observed four types of epidermal gland cell, which presumably provide the attachment and reattachment to the substrate. Supposedly, the musculature of rhopalioids can also play a role in the attachment and reattachment. We have studied organization of the nervous system in rhopalioids, which includes FMRFamide‐, tubulin‐ and neurotensin‐positive nerve clusters and FMRFamide‐positive presumptive sensory cells. Based on our results, we assume that rhopalioids, besides the complex attachment, may act like sensory organs and play a role of integrative centres.
The role of glycated hemoglobin in the diagnosis of prediabetes and diabetes mellitus in young women with polycystic ovary syndrome
Authors: Melo Raissa Holanda , Pontes Ana Gabriela , Delmanto Lucia Regina Marques Gomes , Bueloni‐Dias Flavia Neves , Vespoli Heloisa De Luca , Nahas Eliana Aguiar Petri 
Published: October 2023

AbstractObjectiveTo compare glycated hemoglobin (HbA1c) and the oral glucose tolerance test (OGTT) for the diagnosis of prediabetes and diabetes in young women with polycystic ovary syndrome (PCOS).Patients and DesignThis cross‐sectional study included 154 women aged 20–40 years with a diagnosis of PCOS, who were screened for prediabetes and diabetes by the OGTT and HbA1c. Women with diabetes, hyperprolactinemia, thyroid or adrenal diseases, and anemia and users of hormonal contraception or corticosteroids were excluded.MeasurementsClinical, biochemical and ultrasound data were collected from the electronic medical records. The women were classified as having normal glucose metabolism, prediabetes, or diabetes based on the diagnostic tests. Sensitivity and specificity were calculated and the Kappa method was used to assess agreement between the two methods.ResultsAccording to the OGTT and HbA1c values, 79.2% and 76% of the women were within the normal range, respectively, 16.8% and 19.5% had prediabetes, and 4% and 4.5% had diabetes (p > .05). The Kappa coefficient of 0.41 (95% confidence interval: 0.24–0.58) indicated medium agreement between methods. Considering the OGTT as the gold standard, the specificity of HbA1c was 89.5% and sensitivity was 85.7% in the diagnosis of prediabetes and 100% and 66.7%, respectively, in the diagnosis of diabetes.ConclusionThe HbA1c, when compared to the OGTT, showed high sensitivity and specificity in the diagnosis of prediabetes in young women with PCOS.
A Survey of Procedural Modelling Methods for Layout Generation of Virtual Scenes
Authors: Cogo Emir , Krupalija Ehlimana , Prazina Irfan , Bećirović Šeila , Okanović Vensada , Rizvić Selma , Mulahasanović Razija Turčinhodžić 
Published: October 2023

AbstractAs virtual worlds continue to rise in popularity, so do the expectations of users for the content of virtual scenes. Virtual worlds must be large in scope and offer enough freedom of movement to keep the audience occupied at all times. For content creators, it is difficult to keep up by manually producing the surrounding content. Therefore, the application of procedural modelling techniques is required. Virtual worlds often mimic the real world, which is composed of organized and connected outdoor and indoor layouts. It is expected that all content is present on the virtual scene and that a user can navigate streets, enter buildings, and interact with furniture within a single virtual world. While there are many procedural methods for generating different layout types, they mostly focus only on one layout type, whereas complete scene generation is greatly underrepresented. This paper aims to identify the coverage of layout types by different methods because similar issues exist for the generation of content of different layout types. When creating a new method for layout generation, it is important to know if the results of existing methods can be appended to other methods. This paper presents a survey of existing procedural modelling methods, which were organized into five categories based on the core approach: pure subdivision, grammar‐based, data‐driven, optimization, and simulation. Information about the covered layout types, the possibility of user interaction during the generation process, and the input and output shape types of the generated content is provided for each surveyed method. The input and output shape types of the generated content can be useful to identify which methods can continue the generation by using the output of other methods as their input. It was concluded that all surveyed methods work for only a few different layout types simultaneously. Moreover, only 35% of the surveyed methods offer interaction with the user after completing the initial process of space generation. Most existing approaches do not perform transformations of shape types. A significant number of methods use the irregular shape type as input and generate the same shape type as the output, which is sufficient for coverage of all layout types when generating a complete virtual world.
Effects of continuous glucose monitoring on glycaemic control in type 2 diabetes: A systematic review and network meta‐analysis of randomized controlled trials
Authors: Lu Jiaping , Ying Zhen , Wang Ping , Fu Minjie , Han Chenyu , Zhang Min 
Published: October 2023

AbstractAimsThe aim of this study was to assess the efficacy of continuous glucose monitoring (CGM) versus self‐monitoring of blood glucose (SMBG) in maintaining glycaemic control among people with type 2 diabetes mellitus (T2DM).Materials and MethodsThe protocol was registered in PROSPERO (CRD42023387583). PubMed, Web of Science, EMBASE and OVID databases were searched from 1 January 2000 until 31 December 2022 for randomized controlled trials comparing CGM with SMBG in glycaemic control among the outpatients with T2DM. The primary endpoint was glycated haemoglobin, while the secondary endpoints included time in range, time below range and time above range. Both traditional and network meta‐analyses were conducted to explore the efficacy of CGM on glycaemic control in T2DM.ResultsEleven high‐quality studies, involving 1425 individuals with T2DM, were identified. Traditional meta‐analysis revealed that CGM exhibited a significantly decreased [mean difference (MD): −0.31, 95% confidence interval (CI) (−0.45, −0.18)], time above range [MD: −9.06%, 95% CI (−16.00, −2.11)], time below range [MD: −0.30%, 95% CI (−0.49, −0.12)] and a significantly increased time in range [MD: 8.49%, 95% CI (3.96, 13.02)] compared with SMBG. The network meta‐analysis showed that real‐time CGM can improve the glycaemic control of patients with T2DM to the most extent.ConclusionsCGM could provide T2DM with greater benefits in glycaemic management compared with SMBG, particularly in patients using real‐time CGM. These findings provide an updated perspective on previous research and offer guidance for CGM use in T2DM.