bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Squalene‐Hopene Cyclase Inhibitors Derived from Hydroxycoumarins and Hydroxyacetophenones.
Authors: Cravotto Giancarlo , Balliano Gianni , Tagliapietra Silvia , Oliaro‐Bosso Simonetta , Nano Gian Mario 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of Dihydro Selenolo (2,3‐b)Quinoline‐2‐carboxylic Ethyl Esters and 2‐Selenoxo‐1, 2‐Dihydro‐3‐carbethoxy Ethyl Quinolines — Their Antibacterial Studies.
Authors: Nithyadevi V. , Selvi P. , Rajendran S. P. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
1,3‐Cyclohexanedione in the Synthesis of Fused Derivatives of 4,7‐Phenanthroline
Authors: Kozlov N. G. , Gusak K. N. , Tereshko A. B. , Firgang S. I. , Shashkov A. S. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Farnesyl Protein Transferase Inhibitors Targeting the Catalytic Zinc for Enhanced Binding.
Authors: Njoroge F. George , Vibulbhan Bancha , Pinto Patrick , Strickland Corey , Kirschmeier Paul , Bishop W. Robert , Girijavallabhan V. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bridgehead Modification of Trihalocycloheptabenzopyridine Lead to a Potent Farnesyl Protein Transferase Inhibitor with Improved Oral Metabolic Stability.
Authors: Njoroge F. George , Vibulbhan Bancha , Shi Xiongwei , Strickland Corey , Kirschmeier Paul , Bishop Robert , Nomeir Amin , Girijavallabhan Viyyoor 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactions of Cyanothioacetamide: Synthesis of Several New Thioxohydro‐pyridine‐3‐carbonitrile and Thieno[2,3‐b]pyridine Derivatives.
Authors: Attaby Fawzy A. , Eldin Sanaa M. , Elneairy Mohamed A. A. , El‐Louh Ali K. K. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pyridazine Derivatives. Part 39. Reactivity of 5‐Iodopyridazin‐3(2H)‐ones in Palladium‐Catalyzed Reactions.
Authors: Coelho Alberto , Sotelo Eddy , Novoa Hector , Peeters Oswald M. , Blaton Norbert , Ravina Enrique 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Urea Derivatives of STI571 as Inhibitors of Bcr‐Abl and PDGFR Kinases.
Authors: Manley Paul W. , Breitenstein Werner , Brueggen Josef , Cowan‐Jacob Sandra W. , Furet Pascal , Mestan Juergen , Meyer Thomas 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Activity of Some α,ω‐Bis(ammonio)alkanes Containing Oxopyrimidinyl Radicals.
Authors: Zobov V. V. , Aslyamova A. A. , Berezinskii L. A. , Reznik V. S. , Akamsin V. D. , Galyametdinova I. V. , Nafikova A. A. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 4,9‐Dimethyl‐8‐(6‐aryl‐2‐thioxo‐1,2,3,6‐tetrahydro pyrimidin‐4‐yl)‐furo[2,3‐H]chromen‐2‐ones as Antimicrobial Agents under Microwave Irradiation.
Authors: Reddy P. Narsimha , Rao G. V. Panakal , Rao M. Kanakalingeswara , Rajitha B. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
N—H Insertion Reactions of Boc‐Amino Acid Amides: Solution‐ and Solid‐Phase Synthesis of Pyrazinones and Pyrazines.
Authors: Matsushita Hana , Lee Sang‐Hyeup , Yoshida Kazuhiro , Clapham Bruce , Koch Guido , Zimmermann Juerg , Janda Kim D. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors.
Authors: Ishihara Tsukasa , Kakuta Hirotoshi , Moritani Hiroshi , Ugawa Tohru , Yanagisawa Isao 
Published: March 2005

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Preparation of ε‐Caprolactam via Beckmann Rearrangement of Cyclohexanone Oxime: A Mild and Recyclable Process.
Authors: Qiao Kun , Deng Youquan , Yokoyama Chiaki , Sato Hikaru , Yamashina Miki 
Published: March 2005

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A Nonhydrolyzable Analogue of Phosphotyrosine, and Related Aryloxymethano‐ and Aryloxyethano‐phosphonic Acids as Motifs for Inhibition of Phosphatases.
Authors: Iyer Subashree , Younker Jarod M. , Czyryca Przemyslaw G. , Hengge Alvan C. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sulfurization of Trivalent Phosphorus Compounds with 1,2‐Dithiole‐3‐thione.
Authors: Drabowicz Jozef , Luczak Jerzy , Lyzwa Piotr , Mikolajczyk Marian , Pedersen Carl Th. 
Published: March 2005

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The Reaction of Triphenylarsine Oxide with Ethyl Iodo‐acetate Leading to Triphenyl (Carboethoxy)methylarsonium Triiodide.
Authors: Abalonin Boris E. , Nizamov Il'yas S. , Krivolapov Dmitry B. , Nizamov Il'nar D. , Khaibullin Ravil N. , Al'metkina Lyubov A. , Batyeva Elvira S. , Litvinov Igor A. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Insulinomimetic Vanadyl—Hydroxythiazolethione Complexes with VO(S2O2) Coordination Mode: The Correlation Between the Activity and Hammett′s Substituent Constant.
Authors: Katoh Akira , Yamaguchi Mika , Saito Ryota , Adachi Yusuke , Sakurai Hiromu 
Published: March 2005

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3‐O‐Glutaryl‐dihydrobetulin and Related Monoacyl Derivatives as Potent anti‐HIV Agents.
Authors: Kashiwada Yoshiki , Sekiya Michiko , Ikeshiro Yasumasa , Fujioka Toshihiro , Kilgore Nicole R. , Wild Carl T. , Allaway Graham P. , Lee Kuo‐Hsiung 
Published: March 2005

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Synthesis and Biological Evaluation of Novel Taxoids Designed for Targeted Delivery to Tumors.
Authors: Baloglu Erkan , Miller Michael L. , Roller Elizabeth E. , Cavanagh Emily E. , Leece Barbara A. , Goldmacher Victor S. , Chari Ravi V. J. 
Published: March 2005

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Brasilicardins B—D, New Tricyclic Terpenoids from Actinomycete Nocardia brasiliensis.
Authors: Komatsu Kazusei , Tsuda Masashi , Shiro Motoo , Tanaka Yasushi , Mikami Yuzuru , Kobayashi Jun'ichi 
Published: March 2005

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Synthetic Transformations of Higher Terpenoids. Part 11. Synthesis of A‐Nor‐5βH‐19β,28‐epoxy‐18α‐olean‐3‐one Derivatives.
Authors: Medvedeva N. I. , Flekhter O. B. , Tretyakova E. V. , Galin F. Z. , Baltina L. A. , Spirikhin L. V. , Tolstikov G. A. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Spongiacysteine, a Novel Cysteine Derivative from Marine Sponge Spongia sp.
Authors: Kobayashi Keiko , Shimogawa Hiroki , Sakakura Akira , Teruya Toshiaki , Suenaga Kiyotake , Kigoshi Hideo 
Published: March 2005

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Chlorothiophenecarboxamides as P1 Surrogates of Inhibitors of Blood Coagulation Factor Xa.
Authors: Mederski Werner W. K. R. , Cezanne Bertram , van Amsterdam Christoph , Buehring Karl‐Ulrich , Dorsch Dieter , Gleitz Johannes , Maerz Joachim , Tsaklakidis Christos 
Published: March 2005

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Synthesis and Biological Evaluation of an Orally Active Ghrelin Agonist that Stimulates Food Consumption and Adiposity in Rats
Authors: Lugar Charles W. , Clay Michael P. , Lindstrom Terry D. , Woodson Andrea L. , Smiley David , Heiman Mark L. , Dodge Jeffrey A. 
Published: March 2005

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Asymmetric Synthesis of cis‐5‐Substituted Pyrrolidine 2‐Phosphonates Using Metal Carbenoid NH Insertion and δ‐Amino β‐Ketophosphonates.
Authors: Davis Franklin A. , Wu Yongzhong , Xu He , Zhang Junyi 
Published: March 2005

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A Potentially Divergent and Rapid Route to Analogues of Deoxycyclitols, Pentopyranoses, 6‐Deoxyhexoses, and Hexoses
Authors: Audouard Christophe , Fawcett John , Griffith Gerry A. , Kerouredan Erwan , Miah Afjal , Percy Jonathan M. , Yang Hongli 
Published: March 2005

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The First Ring Inversion of Pyranoses Induced by Bulky Silyl Protections at the 2‐ and 3‐Positions.
Authors: Yamada Hidetoshi , Tanigakiuchi Koki , Nagao Kohei , Okajima Kotaro , Mukae Tatsuya 
Published: March 2005

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Inactivation of S‐Adenosylhomocysteine Hydrolase with Haloethyl and Dihalocyclopropyl Esters Derived from Homoadenosine‐6′‐carboxylic Acid.
Authors: Guillerm Georges , Muzard Murielle , Glapski Cedric 
Published: March 2005

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anti‐Cancer Activity Profile of 3′‐Azidothymidine 5′‐[p‐Methoxyphenyl Methoxyalaninyl Phosphate] (Compound 003), a Novel Nucleoside Analogue.
Authors: Uckun Fatih M. , Vassilev Alexei O. , Dibirdik Ilker , Liu Xing‐Ping , Erbeck Douglas , Tibbles Heather E. , Qazi Sanjive , Venkatachalam Taracad K. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
anti‐AIDS Agents. Part 62. anti‐HIV Activity of 2′‐Substituted 4‐Methyl‐3′,4′‐di‐O‐(‐)‐camphanoyl‐(+)‐cis‐khellactone (4‐Methyl DCK) Analogues.
Authors: Zhang Qian , Chen Ying , Xia Peng , Xia Yi , Yang Zheng‐Yu , Yu Donglei , Morris‐Natschke Susan L. , Lee Kuo‐Hsiung 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Antitumor Agents. Part 239. Isolation, Structure Elucidation, Total Synthesis, and anti‐Breast Cancer Activity of Neo‐tanshinlactone from Salvia miltiorrhiza.
Authors: Wang Xihong , Bastow Kenneth F. , Sun Chang‐Ming , Lin Yun‐Lian , Yu Hsi‐Jung , Don Ming‐Jaw , Wu Tian‐Shung , Nakamura Seikou , Lee Kuo‐Hsiung 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lower Oxidation States of F Elements. Part 1. Preparation and Identification of Actinides and Lanthanides in Lower Oxidation States
Authors: Mikheev N. B. , Kulyukhin S. A. , Kamenskaya A. N. , Rumer I. A. , Konovalova N. A. 
Published: March 2005

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Perspectives on 1,4‐Benzodioxins, 1,4‐Benzoxazines and Their 2,3‐Dihydro Derivatives
Authors: Achari Basudeb , Mandal Sukhendu B. , Dutta Pradeep K. , Chowdhury Chinmay 
Published: March 2005

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Pharmacology and Structure—Activity Relationships of Bioactive Polycyclic Cage Compounds: A Focus on Pentacycloundecane Derivatives
Authors: Geldenhuys Werner J. , Malan Sarel F. , Bloomquist Jeffrey R. , Marchand Alan P. , Van der Schyf Cornelis J. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Early‐stage carcinoids of the gastrointestinal tract
Authors: Soga Jun 
Published: March 2005

AbstractBACKGROUNDGastrointestinal (GI) carcinoids, considered to be endocrine neoplasms with relatively low levels of malignancy, have never been examined in large, statistically reliable series to determine their true aggressive behavior in the early stage of both minute (≤ 5 mm) or small (5.1–10.0 mm) tumors at a depth of invasion restricted to the mucosa and submucosa (sm carcinoids).METHODSOf a total number of 1914 cases of GI sm carcinoids selected from the Niigata Registry, 1614 with the tumor size recorded on a millimeter scale were categorized in 5‐mm size intervals and rates of metastases were calculated for those in each size category. Of statistical significance was confirmation that the rectum (n = 849), the stomach (n = 449), the duodenum (n = 349), and the jejunoileum (n = 149) were among the principal growth sites. The Kaplan–Meier method was used to calculate 5‐year‐survival rates (5YSRs) and a comparative study was undertaken.RESULTSGI sm carcinoids exhibited a metastasis rate of 16.4% (264 of 1614) as a whole and minute carcinoids (≤ 5 mm) revealed an unexpectedly high metastasis rate of 6.0% (24 of 399) on average, which ranged from 3.7% (8 of 216) in the rectum to 17.2% (5 of 29) in the jejunoileum. Small carcinoids measuring 5.1–10 mm also showed a high metastasis rate of 13.3% (90 of 675) on average, ranging from 9.6% (12 of 125) in the stomach to 41.2% (14 of 34) in the jejunoileum. The combined average metastasis rate for both minute and small carcinoids combined (≤ 10 mm) was as high as 10.6% (114 of 1074). The comparative study confirmed that, in both the stomach and the rectum, the metastasis rate of sm carcinoids was significantly higher than that for ordinary sm carcinomas in tumors > 10 mm. Although most patients (92.8%; 1777 of 1914) underwent an endoscopy and/or a wider resection of the lesions, nonresectable metastases were found in 22 patients (1.1%). Of these, 16 had undergone a laparotomy and 6 had not received surgery. Among 1001 patients with GI sm carcinoids, the 5YSRs after curative resection ranged from 98.3% in the rectum to 89.6% in the stomach (P < 0.05), representing an average of 96.7% for the entire series.CONCLUSIONSUnexpectedly high aggressiveness in metastasis rates in both rectal and gastric sm carcinoids > 10 mm exhibiting values significantly higher than those of sm carcinomas were found in 1914 patients suffering from GI sm carcinoids. However, in sm carcinoids at either the minute or small tumor stage (tumors ≦ 10 mm), the metastasis rates were comparable to those of sm carcinomas. It should be emphasized that the 5YSRs for patients with GI sm carcinoids may be comparable to those with sm carcinomas in certain cases. These points should be taken into consideration when treating patients with GI carcinoids, particularly in the early stage, and even with the depth of invasion confined to the submucosa. Cancer 2005. © 2005 American Cancer Society.
Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission
Authors: Yanada Masamitsu , Matsuo Keitaro , Emi Nobuhiko , Naoe Tomoki 
Published: March 2005

AbstractBACKGROUNDThe efficacy of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) from a human leukocyte antigen‐identical sibling donor remains controversial for patients with acute myeloid leukemia (AML) in first complete disease remission (CR1). Because the karyotype identified at diagnosis is the most relevant prognostic factor for AML, it should be possible to assess the efficacy more accurately on the basis of cytogenetic risk.METHODSThe authors performed a metaanalysis of five studies, which employed both natural randomization based on donor availability and intention‐to‐treat analysis, with overall survival as an outcome of interest. Metaregression analysis was then performed to identify the efficacy for patients stratified into the favorable, intermediate, and poor cytogenetic risk groups.RESULTSFor the entire cohort, there was a statistically significant advantage with allo‐HSCT in terms of overall survival with a summary hazard ratio of 1.15 (95% confidence interval, 1.01–1.32, P = 0.037) for the random‐effect model. Metaregression analysis showed a significant coefficient of +0.24 for the poor cytogenetic risk group, and −0.25 for the favorable cytogenetic risk group, indicating that the benefit of allo‐HSCT was further increased for the former, and lost for the latter. The coefficient for the intermediate cytogenetic risk group was +0.09, and was not statistically significant.CONCLUSIONSThese findings suggested that the efficacy of allo‐HSCT for patients with AML in CR1 depended on cytogenetic risk. The beneficial effect of allo‐HSCT was yielded for the poor risk group, and probably for the intermediate risk groups, but was absent for the favorable risk group. Cancer 2005. © 2005 American Cancer Society.
Snail, Slug, and Smad‐interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
Authors: Elloul Sivan , Bukholt Elstrand Mari , Nesland Jahn M. , Tropé Claes G. , Kvalheim Gunnar , Goldberg Iris , Reich Reuven , Davidson Ben 
Published: March 2005

AbstractBACKGROUNDIt was demonstrated previously that the Snail family of transcription factors and Smad‐interacting protein 1 (Sip1) regulate E‐cadherin and matrix metalloproteinase 2 (MMP‐2) expression, cellular morphology, and invasion in carcinoma. For the current study, the authors analyzed the relation between the expression of Snail, Slug, and Sip1; the expression of MMP‐2 and E‐cadherin; and clinical parameters in patients with metastatic ovarian and breast carcinoma.METHODSOne hundred one fresh‐frozen, malignant effusions from patients who were diagnosed with gynecologic carcinomas (78 ovarian carcinomas and 23 breast carcinomas) were studied for mRNA expression of Snail, Slug, Sip1, MMP‐2, and E‐cadherin using reverse transcriptase‐polymerase chain reaction analysis. Snail mRNA and E‐cadherin protein expression levels also were studied in ovarian carcinoma effusions using in situ hybridization and immunocytochemistry. The results were analyzed for possible correlation with clinicopathologic parameters in both tumor types.RESULTSE‐cadherin mRNA expression was lower in breast carcinoma (P = 0.001), whereas Snail expression was higher (P = 0.003). The Snail/E‐cadherin ratio (P < 0.001) and the Sip1/E‐cadherin ratio (P = 0.002) were higher in breast carcinomas. Sip1 mRNA expression (P < 0.001) and Slug mRNA expression (P < 0.001) were correlated with the expression of MMP‐2 in ovarian carcinomas. The Sip1/E‐cadherin ratio was higher in primary ovarian carcinomas at the time of diagnosis compared with postchemotherapy ovarian carcinoma effusions (P = 0.003), higher in Stage IV tumors compared with Stage III tumors (P = 0.049), and higher in pleural effusions compared with peritoneal effusions (P = 0.044). In a univariate survival analysis of patients with ovarian carcinoma, a high Sip1/E‐cadherin ratio predicted poor overall survival (P = 0.018). High E‐cadherin mRNA expression predicted better disease‐free survival (P = 0.023), with a similar trend for a low Slug/E‐cadherin ratio (P = 0.07). High Snail mRNA expression predicted shorter effusion‐free survival (P = 0.008), disease‐free survival (P = 0.03), and overall survival (P = 0.008) in patients with breast carcinoma.CONCLUSIONSTranscription factors that regulate E‐cadherin were expressed differentially in metastatic ovarian and breast carcinoma. Snail may predict a poor outcome in patients who have breast carcinoma metastatic to effusions. E‐cadherin expression generally was conserved in effusions from patients with ovarian carcinoma, but the subset of patients with postulated Sip1‐induced repression of this adhesion molecule had a significantly worse outcome. This finding was in agreement with the stronger suppression of E‐cadherin by Snail and Sip1 in breast carcinoma effusions, a clinical condition associated with extremely poor survival. Cancer 2005. © 2005 American Cancer Society.
Recent advances in understanding the cell death pathways activated by anticancer therapy
Authors: Kim Ryungsa 
Published: March 2005

AbstractOver the past two decades, the role of apoptosis in the cytotoxicity of anticancer drugs has become clear. Apoptosis may occur via a death receptor‐dependent (extrinsic) or independent (intrinsic or mitochondrial) pathway. Mitochondria play a central role in cell death in response to DNA damage, and mediate the interaction(s) of various cytoplasmic organelles, including the endoplasmic reticulum, Golgi apparatus, and lysosomes. The mitochondrial pathway of cell death is mediated by Bcl‐2 family proteins, a group of antiapoptotic and proapoptotic proteins that regulate the passage of small molecules, such as cytochrome c, Smac/Diablo, and apoptosis‐inducing factor, which activates caspase cascades, through the mitochondrial transition pore. In addition, apoptosis can induce autophagic cell death via crosstalk between the two pathways upon treatment with anticancer drugs. The current review focused on recent advances surrounding the mechanism(s) of cell death induced by anticancer agents and discussed potential molecular targets for enhancing the chemotherapeutic effect(s) of anticancer agents. Cancer 2005. © 2005 American Cancer Society.
Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma
Authors: Shinohara Eric T. , Gonzalez Adriana , Massion Pierre P. , Chen Heidi , Li Ming , Freyer Andrea S. , Olson Sandra J. , Andersen Jeremiah J. , Shyr Yu , Carbone David P. , Johnson David H. , Hallahan Dennis E. , Lu Bo 
Published: March 2005

AbstractBACKGROUNDSurvivin, which is a member of the inhibitor of apoptosis protein gene family, regulates both programmed cell death and mitosis. It has been shown that survivin expression and its subcellular localization both have prognostic value for patients with malignant disease. In this study, the authors investigated whether nuclear or cytoplasmic staining of survivin was a prognostic marker for patients with lung carcinoma.METHODSParaffin‐embedded tissue blocks from 144 patients with Stage I and II resected nonsmall cell lung carcinoma (NSCLC) were obtained for immunohistochemical staining. Three specimens from each patient were prepared and stained with a survivin‐specific antibody. Nuclear and cytoplasmic staining was graded from 1 to 3 based on intensity.RESULTSPatients who had nuclear staining for survivin had a significantly increased risk of disease recurrence (hazard ratio, 2.95; P = 0.0046) and death (hazard ratio, 2.74; P = 0.0086).CONCLUSIONSThe nuclear presence of survivin may be an independent biomarker for disease recurrence and overall survival in patients with resected Stage I and II NSCLC. Cancer 2005. © 2005 American Cancer Society.
Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy
Authors: Rades Dirk , Schild Steven E. , Bahrehmand Roja , Zschenker Oliver , Alberti Winfried A. , Rudat Volker R. 
Published: March 2005

AbstractBACKGROUNDThe current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma.METHODSThe following potential prognostic factors were retrospectively investigated in 124 patients treated with radiotherapy (RT) alone or with radiochemotherapy: age, gender, performance status, tumor location, tumor length, histology, histologic grade, T classification, N classification, International Union Against Cancer stage, chemotherapy, RT dose, and pre‐RT hemoglobin level.RESULTSUsing univariate analysis (Kaplan–Meier method), pre‐RT hemoglobin level, RT dose, tumor length, chemotherapy, and performance status were significantly associated with OS. Hemoglobin levels of 12.1–14.0 g/dL were associated with the best OS, followed by ≥ 14.1 g/dL and ≤ 12.0 g/dL. DM was significantly influenced by tumor length, RT dose, N classification, and performance status. LF was significantly influenced by pre‐RT hemoglobin level, RT dose, and tumor length. Using multivariate analysis (Cox proportional hazard model), pre‐RT hemoglobin maintained significance for OS (P < 0.001) and LF (P < 0.001), RT dose for OS (P = 0.001), DM (P = 0.031), and LF (P < 0.001), tumor length for OS (P = 0.003), DM (P = 0.017), and LF (P = 0.033), and chemotherapy for OS (P = 0.027). N classification was of borderline significance for DM (P = 0.054). Performance status lost significance for OS (P = 0.73) and LF (P = 0.22).CONCLUSIONSThe strongest predictors for outcome in Stage II/III esophageal carcinoma were RT dose, tumor length, pre‐RT hemoglobin level, and chemotherapy. The pre‐RT hemoglobin level was an independent prognostic factor significantly associated with OS and LF. A hemoglobin level of 12.1–14 g/dL resulted in a better prognosis than hemoglobin levels ≥ 14 g/dL and ≤ 12 g/dL. Cancer 2005. © 2005 American Cancer Society.