bluuebunny/crossref_metadata_2025_split huggingface dataset:
Necroptosis-Related Genes Associated with Immune Activity and Prognosis of Colorectal Cancer
Authors: Tan Lulu , Ren Yahui , Wang Di , Zhang Xiaoying , Deng Rui , Zhu Weiwei , Xiao Juan , Tan Yuyan , Liu Zhibo 
Published: October 2023

Abstract
Background: Necroptosis is critical in the occurrence and development of many malignancies, CRC is one of the top causes of cancer-related deaths globally. However, the association between necroptosis-related genes (NRGs) and colorectal cancer (CRC) remains controversial. Therefore, the present study aims to construct a novel signature based on NRG to predict the prognosis of CRC patients and investigate its possible role.
Methods: The transcriptome data from Gene Expression Omnibus (GEO) databases and the Cancer Genome Atlas (TCGA) were utilized to identify cancer hallmarks that are associated with outcomes in colorectal cancer (CRC). A new NRG signature was created and confirmed through least absolute shrinkage and selection operator (LASSO) regression analysis and COX regression analysis. Subsequently, univariate and multivariate Cox regression analysis, K-M survival analysis, ROC, and nomogram were applied to assess the predictive value of our signature. Additionally, the potential mechanisms, tumor immune status, and drug sensitivity differences were uncovered in the two-risk groups by using a variety of bioinformatics analysis algorithms. The expression of signature NRG in CRCs was evaluated through RT-qPCR. Finally, we constructed tumor biological experiments to demonstrated the influence of NRGs on the development of colorectal cancer.
Results: A novel signature consisting of eighteen NRGs (CTSB, PAEP, ARL4C, TAP2, WFS1, BATF2, DUSP27, CXCL9, EPHB2, IRF8, CXCL13, GZMB, APOL6, NLRC5, CXCL10, IRF1, HES6, and PTGDR) was eventually established and verified via stable prediction performance and general applicability for CRC, which was validated in three independent cohorts. Further, stromal and immune cells in the tumor microenvironment (TME) were found to be associated with necroptosis. Additionally, there were significant differences in the sensitivity to anti-tumor agents between the two groups. The qPCR results indicated that these signature NRGs were abnormally expressed in CRC, and the in vitro and in vivo experiments demonstrated that NRGs have a great influence on the progression of CRC.
Conclusion: NRG is an accurate predictor of CRC prognosis. Besides，the novel signature displays stable value and translational potential for predicting prognosis, tumor immunogenicity, and therapeutic response in CRC.
CTA Imaging Features and Prognosis in Emergency Type A Aortic Dissection Admissions
Authors: Matniyaz Yusanjan , Wang Wen-Zhe , Zhang Ke-Yin , Ni Jian , Wang Dong-Jin 
Published: October 2023

Abstract

Background
Acute Type A aortic dissection (ATAAD) is a life-threatening condition requiring prompt surgical intervention. This retrospective study aimed to identify preoperative computed tomography angiography (CTA) features associated with in-hospital mortality in ATAAD patients. We examined specific CTA characteristics and their implications for patient outcomes.
Methods
We conducted a retrospective analysis of 384 patients diagnosed with ATAAD who underwent emergency surgery at Nanjing Drum Tower Hospital between March 2019 and March 2022. Their pre-admission CTA images were interpreted by experienced radiologists. The patients were divided into two groups: the survival group and the mortality group. We used logistic regression to assess the impact of various CTA features finding on in-hospital mortality rates between these two groups.
Results
Our study revealed significant associations between specific CTA findings and in-hospital mortality in ATAAD patients. Notably, the absence of visible fenestration (OR = 2.296, 95% CI: 1.005–5.245, P = 0.049), involvement of the superior mesenteric artery (OR = 4.805, 95% CI: 1.977–11.677, P < 0.001), a total ascending aortic diameter ≥ 4.7 cm (OR = 3.040, 95% CI: 1.326–6.970, P = 0.009), and the presence of multiple tears (OR = 0.094, 95% CI: 0.012–0.717, P = 0.022) were linked to mortality risk. These associations held true even after adjusting for potential confounders in multivariable analyses. The logistic regression model demonstrated good discriminative ability with an area under the ROC curve of 0.726.
Conclusion
In conclusion, this study identified preoperative CTA features that can help predict in-hospital mortality in ATAAD patients. The absence of visible fenestration and involvement of the superior mesenteric artery, a total ascending aortic diameter ≥ 4.7 cm, the presence of multiple tears were significant risk factors. These findings emphasize the importance of careful assessment and consideration of these CTA characteristics when managing ATAAD patients. Future research should explore additional factors and consider multicenter, prospective studies for a more comprehensive understanding of ATAAD prognosis and treatment strategies.
Trial registration
The study received approval from the ethical committees of Nanjing Drum Tower Hospital (No.2022-157-01) and individual consent for this retrospective analysis was waived.
Factors influencing adult patient communication experiences with nurses in cancer care settings: A cross-sectional study
Authors: Alshammari Mukhlid , Duff Jed , Guilhermino Michelle 
Published: October 2023

Abstract
Background Effective communication among patients and nurses in cancer care is important in improving health outcomes and patient experience. However, there are several factors that influence patients communication experiences in healthcare. This study aimed to identify patients characteristics that influence patient-nurses communication experiences in cancer care settings.Methods Convenience sampling was used to recruit participants in cancer care. A validated questionnaire was administered to measure the factors influencing patient communication experiences. The questionnaire contains 48 items, including participants characteristics and patient-centred communication items (based on the Patient-centered Communication model). Independent t-tests, one-way univariate analyses of variances and bivariate correlations were used followed by a stepwise linear regression model.Results A total of 318 participants responded to the questionnaire at two tertiary health facilities in Saudi Arabia. Overall, most participants reported that their communication with nurses during their cancer care was patient-centred. Patients felt that the nurses fostered healing relationships, and there was a free exchange of information. Patients identified areas for improvement in how nurses managed uncertainty and how they support patient self-management. Older and male patients reported better communication experiences. Patients with aphasia reported worse communication experiences.Conclusions This study suggested that cancer patients’ perceptions of nurse-patient communication vary between groups. Nurses, health care planners and policymakers should recognise these differences when delivering, planning and monitoring health care activities.
Comparison of High-Flow Nasal Cannula with Conventional Oxygen Therapy for Preventing Postoperative Hypoxemia in Patients with Lung Resection Surgery: A Meta-Analysis of Randomized Controlled Trials
Authors: zhang xingxing , li xiaoqing , li yang , wang wenchun , yu yun 
Published: October 2023

Abstract
Background: The efficacy of high-flow nasal cannula (HFNC) in patients extubated after lung resection surgery remains inconclusive. Our objective was to execute a meticulous systematic meta-analysis to accurately assess the advantages of HFNC for patients extubated after lung resection surgery, by examining postoperative hypoxemia and other patient-focused outcomes.
Research question: For patients extubated after lung resection surgery, is HFNC an effective alternative to conventional oxygen therapy in reducing the risk of postoperative hypoxemia?
Method: We searched PubMed, EMBASE, the Cochrane Library, and Web of Science to identify randomized controlled trials (RCT) from inception to July 2023. We employed the revised Cochrane Risk of Bias Tool(2.0) to evaluate the risk of bias of the included studies, and the GRADE method to ascertain the certainty of the pooled effect estimates. The primary outcome was the incidence of postoperative hypoxemia.
Results: Five RCTs (n=564) were included in the ultimate analysis. Utilizing HFNC rather than COT did not reduce the risk of postoperative hypoxemia (relative risk (RR), 0.67; 95%CI, 0.30, 1.49;low certainty). Compared to COT, HFNC may significantly enhance oxygenation index within first 12 hours after extubation in patients with lung resection. There were no significant differences in reintubation rate(RR, 0.25; 95%CI, 0.04, 1.54; high certainty), escalation of respiratory support(RR, 0.35; 95%CI, 0.11, 1.08; high certainty), change in PaCO2 within first 24 hours after extubation, hospital length of stay (mean difference (MD), −0.19; 95%CI, –0.44, 0.06; moderate certainty), and ICU length of stay (MD, 0.02; 95%CI, −0.16, 0.19;high certainty).
Conclusions: Our meta-analysis revealed that, compared to COT, HFNC could significantly enhance the oxygen index within the first 12 hours in patients extubated after lung resection surgery, with no significant differences in other outcomes. To verify the effect of HFNC on this population, additional large-scale, multicenter studies are essential.
The Effect of Interventions on Human Papillomavirus Vaccination Rate Based on Information-Motivation-Behavioral Skills Model for 11-13-Year- Old Girls in Central and Western China: a Study Protocol for a Randomized Controlled Trial
Authors: Jing Shu , Wu Yijin , Huang Yiman , Si Mingyu , Dai Zhenwei , Liu Xin , Zhang Ling , Chen Xu , Fu Jiaqi , Wang Hao , Xiao Weijun , Su Xiaoyou , Tang Shenglan , Qiao Youlin 
Published: October 2023

Abstract

Background Persistent infection of high-risk human papillomavirus (HPV) can lead to cervical intraepithelial neoplasia (CIN), cervical cancer, and even death. HPV vaccination for girls ages 9 to 14 years can effectively prevent the occurrence of cervical cancer. Free HPV vaccination pilot projects will be carried out among this population by our research team in central and western China. However, some parents might refuse to vaccinate their daughters. This protocol reports the design of a randomized controlled trial aiming to explore the efficacy of a mobile-based education intervention based on the Information-Motivation-Behavioral skills (IMB) model, in improving the HPV vaccination rate of 11-13-year-old girls in central and western China. Methods A multicenter intervention study based on an online applet will be conducted in March 2024, and at least 750 eligible parents of 11-13-year-old girls will be assigned 1:1 to an intervention group receiving a 7-day mobile-based education on HPV vaccines based on the IMB model or control group using non-HPV publicity materials. All participants will be asked to complete online questionnaires at baseline, post-intervention, and 1, 2, and 3 months after the intervention. The primary outcome of this study will be receipt of the first HPV vaccination or appointments for HPV vaccination within 3 months. Data will be analyzed based on an intention-to-treat approach, and SAS 9.4 will be used for statistical analysis. Discussion This study aims to improve the HPV vaccination rate of 11-13-year-old girls and will examine the impact of a mobile-based education on HPV vaccines, based on IMB model. The findings of this study may offer promising intervention measures on HPV vaccine hesitancy in low health resource areas in the future. Trial registration: Chinese Clinical Trial Registry (ChiCTR), ChiCTR2300067402; Registered on 6 January 2023.
Seasonal Variation of Mycotoxin Levels in Poultry Feeds and Feed Ingredients in Oyo State, Nigeria.
Authors: Esan Oluwaseun Olanrewaju , Okanlawon Abidoye Abiodun , Ogunro Bamidele Nyemike , Abiola John Olusoji , Olaogun Sunday Charles , Aliyu Victor Ayodele 
Published: October 2023

Abstract
Mycotoxins pose a major problem to poultry production as a result of feed contamination which has deleterious consequences such as production losses and human health risks. A total of 158 chicken feed samples were randomly collected from 46 consenting poultry farms in Oyo State throughout the Wet season (April-October; 91 samples) and the Dry season (November-March; 67 samples), including compounded feed (n = 129) and feed ingredients (n = 29). Samples were promptly transported to the laboratory in sterile plastic vials for Lateral Flow Assay for mycotoxins using six different commercial mycotoxin test kits each for Aflatoxin, Zearalenone, Deoxynivalenol, Ochratoxin, Fumonisin, and T-2 Toxin/HT-2 Toxin. Summary values mycotoxin levels (nanogram per gram) in the feedstuffs were represented as frequency or median (and range). Fisher Exact or Mann-Whitney U tests were carried out where appropriate at α = 0.05. Every sample contained at least four mycotoxins. Aflatoxins and Fumonisin co-occurred in 80% of the samples. Aflatoxin and Fumonisin concentrations were above the permissible limits in 49% and 46% respectively in feedstuff sampled in Dry season while the values were 22% and 26% respectively during the Wet season. Among feed ingredients, peanut cake and maize had the highest median concentration of Aflatoxin and Fumonisin, respectively. Median Aflatoxin concentration in the feedstuff was significantly higher than the permissible limit irrespective of season. There is a need to frequently monitor mycotoxin levels of feed and feed ingredients and improve storage system for feed ingredients in order to reduce the risk associated with high mycotoxin intake in poultry.
CAR T cells and T cells phenotype and function are impacted by glucocorticoid exposure with different amplitude.
Authors: Poiret Thomas , Vikberg Sara , Schoutrop Esther , Mattsson Jonas , Magalhaes Isabelle 
Published: October 2023

Abstract
Background. Chimeric antigen receptor (CAR) T cell therapy is associated with high risk of adverse events. Glucocorticoids (GCs) are cornerstone in the management of high-grade cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Given the potentially deleterious effects of GCs on CAR T cells anti-tumor activity, increasing our understanding of GCs impact on CAR T cells is crucial.
Methods. Using several CAR T cells i.e., CD19, mesothelin (MSLN)-CD28 and MSLN-41BB CAR T cells (M28z and MBBz), we compared phenotypical, functional, changes and anti-tumor activity between i) transduced CD19 CAR T cells with untransduced T cells, ii) M28z with MBBz CAR T cells induced by Dexamethasone (Dx) or Methylprednisolone (MP) exposures.
Results. Higher levels of GC receptor were found in less differentiated CAR T cells. Overall, Dx and MP showed a similar impact on CAR T cells. GC exposures induced more exhausted (LAG3+PD1+TIM3+) and dysfunctional (CD107a-INFγ-TNF-IL2-) untransduced T cells in comparison to CD19 CAR T cells. GC exposure impaired more CD4+ than CD8+ CD19 CAR T cells. GC exposures increased more PD-1 expression associated with reduced proliferative capacity and function of M28z as compared to MBBz CAR T cells. CAR T cells anti-tumor activity was greatly affected by repeated GC exposure but partly recovered within 48h after GCs withdrawal.
Conclusions. In summary, GCs impacted phenotype and function of untransduced and CAR T cell with different amplitude. The nature of the CAR costimulatory domain influenced the amplitude of CAR T cell response to GCs.
Renewable Energy on American Indian Land
Authors: Parker Dominic , Johnston Sarah , Leonard Bryan , Winikoff Justin B 
Published: October 2023

Abstract

Could utility-scale renewable energy development on American Indian Reservations earn a “double-dividend” by cutting carbon emissions while reducing poverty for tribal nations that want development? This study offers three insights. First, the colonial process of reservation creation left tribes with favorable wind and solar endowments, and these endowments are largest on reservations with the poorest populations. Second, despite favorable endowments, renewable projects on reservations are rare. Thus far, reservation land areas are 46% less likely to host wind facilities and 110% less likely to host solar than comparable adjacent lands. Third, if the disparity in renewable uptake persists, tribes may forego over $19 billion in landowner lease and tax earnings that could be accrued under forecasts of net-zero energy transitions by 2050. We discuss barriers that explain this investment disparity and emphasize this is not a call to impose federal energy priorities on unwilling tribes.
Numerical and experimental investigation of exergy, performance, emissions, combustion characteristics, and cyclic variations of CI engine fueled Karanja oil blended camphor oil and diesel blended camphor oil.
Authors: Gurusamy Manikandaraja , Subramaniyan Malarmannan , Ponnusamy Chandrasekaran 
Published: October 2023

Abstract
This article compares the influence of the blending the low-viscous oxygenated camphor oil with hydrocarbon diesel fuel and high viscous oxygenated Karanja oil. The experiment is conducted in a four-stroke 1-cylinder naturally aspirated Kirloskar compression ignition (CI) engine coupled with an eddy current dynamometer. The three types of fuel blends are prepared by blending the camphor oil with Karanja oil on the volume ratio of 30:70 (C30K70), 50:50 (C50K50), and 70:30 (C70K30), and the other three types of fuels are prepared by blending the camphor oil with diesel on the volume ratio of 30:70 (C30D70), 50:50 (C50D50), and 70:30 (C70D30). The results reveal improvement in the engine performance characteristics of the brake thermal efficiency and brake specific energy consumptions due to the blending of camphor oil either with hydrocarbon diesel fuel or Karanja oil. Further, it also reduces the CO, HC, and smoke emissions with an increase in NO and CO2 emissions. The rate of pressure rise, net heat release rate and cyclic irregularities found to increase with increase in proportion of the camphor oil. The P-v diagram also confirms the lower heat addition period for the C70D30 and C70K30 with an increase in brake thermal efficiency. The actual compression ratio and the actual cut-off ratio are found to have a reasonable correlation with the thermal efficiency of the engine. Second-order polynomial equations were obtained for the engine characteristics using the Curve fitting method, and the characteristic equations confirmed the confidence level of 95%.
Validation of the French version of the Child Perceptions Questionnaire for children aged 11 to 14 years old (CPQ11-14) short-form
Authors: RIOU Margot Charlotte , BOURMAUD Aurélie , BOIZEAU Priscilla , MOLLA Muriel de LA DURE , BOY-LEFEVRE Marie-Laure , FRIEDLANDER Lisa 
Published: October 2023

Abstract

Background
The COHQoL is a set of questionnaires used to evaluate the impact of oral health on children’s quality of life. Although the CPQ8-10 and the P-CPQ have been translated and validated in French, the CPQ11-14 14 has not yet been validated.
Aim
The aim was to develop a French version of the CPQ11-14 16-items.
Design:
The French version of CPQ11-14 was obtained by a forward-backward translation process and pretested. The final version was tested on children aged 11–14 and divided into three groups: children with orofacial clefts, children with rare dental diseases other than clefts, and children without anomalies. We evaluated the reliability with test-retest and internal consistency, and the questionnaire validity with construct validity and discriminant validity. We performed an Exploratory Factory Analysis (EFA).
Results
187 children tested the questionnaire. The ICC of the test-retest was 0.76 and the Cronbach’s alpha was 0.77. The correlation between the CPQ11-14 and self-assessment of oral health and general well-being was > 0.2. Patients with orofacial clefts and rare diseases had significantly higher scores for overall short-form CPQ11-14. The EFA revealed six factors.
Conclusion
The French CPQ11-14 is valid to assess the impact of oral health on children’s quality of life.
Revisit the Regular Sea Water Temperature Drop in the Coral Reef Area off the Thermal Discharge outlet in Nanwan Bay
Authors: Irawan Septiyadi , Chien Hwa , Lai Jian-Wu 
Published: October 2023

Abstract
The aim of this study is to revisit and examine the cooling mechanisms in the vicinity of the thermal discharge outlet in the western region of Nanwan Bay, in light of newly available data sets. These data sets consist of simultaneous in-situ measurements and remote sensing data collected during June-July 2016. The data sets include (a) in-situ data from ADCP, uCTD, and bottom temperature gauges, (b) remote sensing current fields from High Frequency Coastal radar, and (c) satellite SST from Himawari-8. The analysis focuses on the correlation between eddies and cold events, and explores the role of an alternative cooling water mechanism, namely internal wave shoaling. Cold events and cyclonic eddies were identified using indices derived from surface current vectors, including divergence, vorticity, strain, Okubo-Weiss, and IROS. Internal wave run-up events were identified when the propagation speed of the bore, which exhibited a sudden temperature drop, agreed with theoretical predictions. Over the 28-day measurement period, the study identified 16 cold events in the presence of cyclonic eddies and 9 events without eddies. Furthermore, the findings indicated that the phenomenon of internal wave run-up had been underestimated. In summary, the study suggests that eddies may explain roughly 55% of the likelihood of cooling events occurring in Nanwan Bay, while internal wave run-up accounts for approximately 31%. These results underscore the coexistence of both eddies and internal waves in this particular region.