bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired haemophilia A in paediatric patients: A retrospective French cohort of eight cases
Authors: Mouthon Paul , Guy Alexandre , d'Oiron Roseline , Harroche Annie , Lebreton Aurélien , Gourguechon Clément , Oudot‐Challard Caroline , Huguenin Yoann 
Published: January 2024

SummaryAcquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new‐onset haemorrhagic symptoms associated with a dramatic decrease in factor VIII levels and an anti‐factor VIII neutralising autoantibody concentration >0.6 Bethesda units. Elderly people are often affected, whereas children are rarely affected; the paediatric incidence reported in the literature is about 0.045 case/million/year. For some time, the paediatric standard of care has been that for adults, but clinicians have often reported poor outcomes. Here, we describe the largest retrospective paediatric AHA cohort assembled to date, including eight patients diagnosed in France from 2000 to 2020.
Protecting the Forest Beings that Protect Us: The Cosmo‐Political ChallengeKawsak SachaPoses to Ecuador's Extraction‐Based Development
Authors: Oikonomakis Leonidas 
Published: January 2024

AbstractSarayaku, an Amazonian Kichwa community in Pastaza province, Ecuador, is suspected to be rich in oil reserves. This fact has generated outside interest in the region and in turn pushed Sarayaku Runa (Sarayaku people) to defend their territory against state‐led extractivist projects. In this context, the conflict in Sarayaku territory, among the state, multinational oil companies and the Indigenous Peoples who inhabit it, goes beyond natural resources. In an effort to distance themselves from the current use of terms such asbuen vivirandPachamamarights, Sarayaku Runa are now inventing new legal and social concepts, such asKawsak Sacha.
Passive cross‐holdings, horizontal differentiation, and welfare
Authors: Fang Jing , Huang Jingyi , Zeng Chenhang 
Published: January 2024

AbstractWe study how passive cross‐holdings affect product differentiation and welfare in a Cournot duopoly. We show that increasing unilateral ownership stimulates total investments, and therefore improves social welfare. Such cross‐holdings should not be controlled in view of social welfare. However, we identify an inverted‐U (a negative) relationship between consumer surplus and ownership when the demand is small (large). Then a government might apply intervention thresholds for passive ownership if it uses consumer surplus as the appropriate standard for antitrust enforcement. We further consider symmetric bilateral cross‐holdings and show that our results are in general robust, but increasing ownership will generate more serious competition harms than unilateral cross‐holdings. Thus, special concerns need to be given to bilateral cross‐holdings.
Submarine fluid flow system feeding methane emission in the northern South China Sea
Authors: Wang Jiliang , Li Ang , Wang Lawrence Hongliang , Wu Shiguo , Li Qingping 
Published: January 2024

AbstractSubmarine fluid flow system can transport methane into ocean. However, its evolution is not fully understood, particularly methane migration through the gas hydrate stability zone (GHSZ) in deep‐water settings. Here, we used 3D seismic and well‐logging data to show the currently active fluid flow system in the northern South China Sea. It was interpreted to have two parts and they together feed intermittent methane emission. Three gas clouds have been seismically imaged beneath the base of gas hydrate stability zone (BGHSZ) and a set of new faults can be identified within them. Twenty‐eight seismic pipes were found to penetrate three vertically stacked mass transport deposits (MTDs) above the gas clouds. Log‐seismic correlation shows that the seismic reflections in the pipe represent MTD sediment, bulk carbonate and gas hydrate‐ or free gas‐bearing sediments. We interpreted faults and pipes as the main migration conduits below and above the BGHSZ respectively. The MTD within the GHSZ could seal the underlying free gas transported by faults and thus overpressure built up at the base prior to the occurrences of the pipes and the fracturing through the overlying sedimentary succession. Subsequently, focused fluid flow entered the GHSZ, with the methane probably bypassing the GHSZ before pore clogging of gas hydrates occurred. Additionally, mapping of high‐amplitude reflections surrounding the upper portion of gas clouds reveals the relict free gas associated with three paleo‐GHSZ bases. Episodic emplacements of new MTDs repeatedly caused the upward shifts of the BGHSZ and the resultant gas hydrate dissociation, contributing to methane emission. We proposed that the occurrences of MTDs may facilitate methane emission by intermittently trapping methane and inducing gas hydrate dissociation in deep‐water settings.
A solider and a victim: Masculinity, violence, and incels celebration of December 6th
Authors: Halpin Michael , Preston Kayla , Lockyer Demeter , Maguire Finlay 
Published: January 2024

AbstractIn 1989, Marc Lépine murdered 14 women at L’École Polytechnique de Montréal. We demonstrate how involuntarily celibate (“incel”) men celebrate Lépine and claim him as a member of their community. Our analysis draws on 637 comments made on incels.is, the main English‐language incel forum, that explicitly mentions Marc Lépine. We argue that incels use Lépine to situate themselves in relation to masculinity and to justify violence against women. First, incels orient to both hegemonic and subordinate masculinity by arguing that feminists are waging a gender war against men. Second, incels celebrate Lépine as a methodical and efficient murderer, connecting both themselves and Lépine to hegemonic masculinity. Third, incels describe both themselves and Lépine as victims of feminists and use this perceived subordination to justify violence against women. We discuss findings in relation to theories of masculinity and policies regulating online communities.
A proposed multi‐domain, digital model for capturing functional status and health‐related quality of life in oncology
Authors: Izmailova Elena S. , Wagner John A. , Bakker Jessie P. , Kilian Rachel , Ellis Robert , Ohri Nitin 
Published: January 2024

AbstractWhereas traditional oncology clinical trial endpoints remain key for assessing novel treatments, capturing patients' functional status is increasingly recognized as an important aspect for supporting clinical decisions and assessing outcomes in clinical trials. Existing functional status assessments suffer from various limitations, some of which may be addressed by adopting digital health technologies (DHTs) as a means of collecting both objective and self‐reported outcomes. In this mini‐review, we propose a device‐agnostic multi‐domain model for oncology capturing functional status, which includes physical activity data, vital signs, sleep variables, and measures related to health‐related quality of life enabled by connected digital tools. By using DHTs for all aspects of data collection, our proposed model allows for high‐resolution measurement of objective data as patients navigate their daily lives outside of the hospital setting. This is complemented by electronic questionnaires administered at intervals appropriate for each instrument. Preliminary testing and practical considerations to address before adoption are also discussed. Finally, we highlight multi‐institutional pre‐competitive collaborations as a means of successfully transitioning the proposed digitally enabled data collection model from feasibility studies to interventional trials and care management.
Digital rhythm training improves reading fluency in children
Authors: Zanto Theodore P. , Giannakopoulou Anastasia , Gallen Courtney L. , Ostrand Avery E. , Younger Jessica W. , Anguera‐Singla Roger , Anguera Joaquin A. , Gazzaley Adam 
Published: January 2024

AbstractMusical instrument training has been linked to improved academic and cognitive abilities in children, but it remains unclear why this occurs. Moreover, access to instrument training is not always feasible, thereby leaving less fortunate children without opportunity to benefit from such training. Although music‐based video games may be more accessible to a broader population, research is lacking regarding their benefits on academic and cognitive performance. To address this gap, we assessed a custom‐designed, digital rhythm training game as a proxy for instrument training to evaluate its ability to engender benefits in math and reading abilities. Furthermore, we tested for changes in core cognitive functions related to math and reading to inform how rhythm training may facilitate improved academic abilities. Classrooms of 8–9 year old children were randomized to receive either 6 weeks of rhythm training (N = 32) or classroom instruction as usual (control; N = 21). Compared to the control group, results showed that rhythm training improved reading, but not math, fluency. Assessments of cognition showed that rhythm training also led to improved rhythmic timing and language‐based executive function (Stroop task), but not sustained attention, inhibitory control, or working memory. Interestingly, only the improvements in rhythmic timing correlated with improvements in reading ability. Together, these results provide novel evidence that a digital platform may serve as a proxy for musical instrument training to facilitate reading fluency in children, and that such reading improvements are related to enhanced rhythmic timing ability and not other cognitive functions associated with reading performance.Research Highlights
Digital rhythm training in the classroom can improve reading fluency in 8–9 year old children
Improvements in reading fluency were positively correlated with enhanced rhythmic timing ability
Alterations in reading fluency were not predicted by changes in other executive functions that support reading
A digital platform may be a convenient and cost‐effective means to provide musical rhythm training, which in turn, can facilitate academic skills
Retraction of health science articles by researchers in Latin America and the Caribbean: A scoping review
Authors: Herrera‐Añazco Percy , Fernandez‐Guzman Daniel , Barriga‐Chambi Fernanda , Benites‐Meza Jerry K. , Caira‐Chuquineyra Brenda , Benites‐Zapata Vicente Aleixandre 
Published: January 2024

AbstractWe aimed to conduct a scoping review to assess the profile of retracted health sciences articles authored by individuals affiliated with academic institutions in Latin America and the Caribbean (LAC). We systematically searched seven databases (PubMed, Scopus, Web of Science, Embase, Medline/Ovid, Scielo, and LILACS). We included articles published in peer‐reviewed journals between 2003 and 2022 that had at least one author with an institutional affiliation in LAC. Data were collected on the year of publication, study design, authors' countries of origin, number of authors, subject matter of the manuscript, scientific journals of publication, retraction characteristics, and reasons for retraction. We included 147 articles, the majority being observational studies (41.5%). The LAC countries with the highest number of retractions were Brazil (n = 69), Colombia (n = 16), and Mexico (n = 15). The areas of study with the highest number of retractions were infectology (n = 21) and basic sciences (n = 15). A retraction label was applied to 89.1% of the articles, 70.7% were retracted by journal editors, and 89.1% followed international retraction guidelines. The primary reasons for retraction included errors in procedures or data collection (n = 39), inconsistency in results or conclusions (n = 37), plagiarism (n = 21), and suspected scientific fraud (n = 19). In conclusion, most retractions of scientific publications in health sciences in LAC adhered to international guidelines and were linked to methodological issues in execution and scientific misconduct. Efforts should be directed toward ensuring the integrity of scientific research in the field of health.
Efficacy and safety of once‐weekly insulin icodec in type 2 diabetes: A meta‐analysis of ONWARDS phase 3 randomized controlled trials
Authors: Shetty Sahana , Suvarna Renuka 
Published: January 2024

AbstractAimInsulin icodec is a novel ultra‐long action basal insulin analogue designed for once‐weekly administration. With the merit of once‐a‐week administration, it promises better adherence and greater treatment satisfaction because of reduced injection frequency. The purpose of this study was to ascertain the efficacy and safety of once‐weekly insulin icodec in comparison with other basal insulin analogues in the management of type 2 diabetes.Materials and MethodsThe PRISMA guidelines were followed during the conduct of this study. For the eligible studies, five databases and ClinicalTrials.gov were screened until July 2023. All randomized controlled trials comparing the efficacy and safety of insulin icodec in type 2 diabetes versus other insulin analogues were included. The extracted data were then analysed for meta‐analysis using RevMan 5.3 software.ResultsFive clinical trials with 3764 participants were included. The meta‐analysis showed that once‐weekly insulin icodec had higher glycated haemoglobin (HbA1c) reduction [mean difference −0.17%, 95% confidence interval (CI; −0.28 to −0.06), p = .003], with no significant difference in fasting plasma glucose compared with other insulin analogues. HbA1c achievement <7% [odds ratio 1.51, 95% CI (1.14‐1.99), p = .004] and HbA1c achievement <7% without hypoglycaemia [odds ratio 1.45, 95% CI (1.26‐1.67), p < .00001] were observed in higher proportions with insulin icodec compared with the comparator group. The percentage of time spent in the target glycaemic range was comparatively similar between insulin icodec and the comparator [mean difference 2.42%, 95% CI (0.01‐4.84), p = .05]. There was a significantly higher incidence of level 1 hypoglycaemia with insulin icodec but no significant difference was seen for the incidence of levels 2, 3 and combined 2/3 hypoglycaemia. Any adverse events and adverse events related to basal insulin were comparably similar in insulin icodec and comparators. The subgroup analysis of once‐weekly insulin icodec with individual insulin analogues (glargine U100 and degludec) showed that insulin icodec had similar efficacy with insulin glargine U100 but superior efficacy with higher HbA1c reduction with insulin icodec compared with insulin degludec. The safety profile was comparable between insulin icodec and glargine U100, whereas insulin icodec reported higher incidence of hypoglycaemia events and any adverse events when compared with degludec.ConclusionOnce‐weekly insulin icodec showed a better HbA1c reduction with a higher proportion of patients achieving HbA1c targets in comparison with once‐daily basal insulin analogues. They were no major safety concerns with respect to hypoglycaemia or adverse events.
Six‐minute walking distance and desaturation–distance ratio in allogeneic stem cell transplantation
Authors: Torralba‐García Yolanda , Alsina‐Restoy Xavier , Torres‐Castro Rodrigo , Gimeno‐Santos Elena , de Llobet‐Viladons Noemi , Rovira‐Tarrats Montserrat , Borràs‐Maixenchs Nuria , Valverde‐Bosch Montserrat , García‐Navarro Carles Agustí , Vilaró Jordi , Blanco Isabel 
Published: January 2024

AbstractBackgroundMost patients with haematological malignancies who undergo allogeneic haematopoietic stem cell transplant (HSCT) receive chemotherapy before the transplant to control the disease. Certain chemotherapy drugs can cause lung toxicity. Conversely, in patients with chronic respiratory conditions, the 6‐min walking test (6MWT) and the desaturation–distance ratio (DDR) have demonstrated prognostic significance. Our objective was to determine whether the 6MWD and DDR, assessed prior to HSCT, have a prognostic impact on survival at 24 months post‐HSCT.MethodsA prospective experimental study was conducted in consecutive patients referred for allogeneic HSCT at Hospital Clinic, Barcelona, Spain. A complete functional respiratory study, including the 6MWT and DDR, was conducted prior to admission. The area under the curve (AUC) and cut‐off points were calculated. Data on patients' characteristics, HSCT details, main events, with a focus on lung complications, and survival at 24 months were analysed.ResultsOne hundred and seventy‐five patients (39% women) with mean age of 48 ± 13 years old were included. Before HSCT, forced vital capacity and forced expiratory volume in the first second were 96% ± 13% predicted and 92% ± 14% predicted, respectively; corrected diffusing capacity for carbon monoxide 79% ± 15% predicted; 6MWD was 568 ± 83 m and DDR of .27 (.20–.41). The cut‐off points for 6MWD and DDR were 566 m, [.58 95% CI (.51–.64)], p = .024 and .306, [.63 95% CI (.55–.70)], p = .0005, respectively. The survival rate at 24 months was 55%.ConclusionOur results showed that individuals who exhibit a 6MWD shorter than 566 ms or a decline in DDR beyond .306 experienced reduced survival rates at 24 months after HSCT.
The Impossibility and Necessity of Causality in Niklas Luhmann's Theory of Education
Authors: Qvortrup Lars 
Published: January 2024

AbstractAccording to Niklas Luhmann, causality is both an impossibility and a necessity in education. On the one hand, the task of the teacher is an impossible one, because teaching as communication is a closed system that cannot determine the learning of pupils' psychical system in any causal sense. On the other hand, one cannot practice as a teacher without a belief in causality, i.e., in a causal connection between teaching and learning. In his article “The Child as the Medium of Education,” Luhmann focuses on the enablement of education, despite its impossibility. His answer is that one thing that makes education possible is the emergence of the symbolically generalized medium “the child.” In this article, Lars Qvortrup focuses on Luhmann's understanding of causality. According to Luhmann, causality is not a simple, ontological fact, but the result of the attribution of certain causes to certain effects. The conclusion is that causality as an attribution category — and not causality as an ontological fact — is another thing that makes education possible. Qvortrup also concludes, however, that Luhmann is not alone in criticizing the traditional, mechanical concept of causality. Other contemporary philosophers and sociologists have pointed out that in order to analyze causality in complex social systems, one has to select some causal factors and ignore others. While others do this based on seemingly pure scientific and statistical criteria, Luhmann focuses on attribution as a social construction of causality.
A grazer's niche edge is associated with increasing diet diversity and poor population performance
Authors: Britnell J. A. , Kerley G. I. H. , Antwis R. , Shultz S. 
Published: January 2024

AbstractThe core‐periphery hypothesis predicts niche cores should be associated with greater survivorship, reproductive output and population performance rates than marginal habitats at niche edges. However, there is very little empirical evidence of whether niche centrality influences population trends in animals. Using the Cape mountain zebra (Equus zebra zebra) as a model system, we evaluated whether niche centrality is associated with population trends, resource availability and diet across a core‐periphery gradient. Population growth rates and density progressively declined towards niche peripheries. Niche peripheries were resource‐poor and Cape mountain zebra consumed more phylogenetically diverse diets dominated by non‐grass families. In core habitats they consumed grass‐rich diets and female reproductive success was higher. This combination of spatial niche modelling and functional ecology provides a novel evaluation of how bottom‐up resource limitation can shape species distributions, population resilience and range change and can guide conservation management.
Artificial intelligence for heart sound classification: A review
Authors: Chen Junxin , Guo Zhihuan , Xu Xu , Jeon Gwanggil , Camacho David 
Published: January 2024

AbstractHeart sound signal analysis is very important for the early identification and treatment of cardiovascular illness. With rapid advancements in science and technology, artificial intelligence technologies are providing tremendous opportunities to enhance diagnosis and clinical decision‐making. Instruments can now perform clinical diagnoses that previously could only be handled by human experts more conveniently and efficiently. Despite multiple works on automatic heart sound analysis, there are few summarization and review works. This article attempts to give a thorough overview of various heart sound analysis subtasks and examine the improvements made in each subtask by both machine learning techniques and deep learning algorithms. It goals to highlight the potential of AI to revolutionize cardiovascular healthcare by enabling accurate and automated analysis of heart sounds. The findings of this review are beneficial for researchers, clinicians, and engineers in the development and application of AI‐based solutions for improved heart sound classification and diagnosis.
Mothers' recollections of parenting by their own mothers and fathers and maternal and infant outcomes
Authors: Huffhines Lindsay , Bailes Lauren G. , Coe Jesse L. , Leerkes Esther M. , Parade Stephanie H. 
Published: January 2024

AbstractObjectiveUsing a family network approach, we examined patterns of remembered parental rearing by both parents and associations with maternal and infant outcomes.BackgroundWomen's memories of how they were cared for by their own mothers in childhood are associated with important outcomes in the perinatal period. However, few studies assess women's recollections of caregiving by their fathers, despite fathers' influence on the larger family context and child adjustment.MethodWe combined data from two prospective longitudinal studies of mothers and their infants (N = 468) in the perinatal period to identify profiles of remembered parental rearing by both parents using latent profile analysis and examined how these profiles were associated with maternal depressive symptoms, mothers' perceived romantic relationship satisfaction, parenting, and infant socioemotional problems.ResultsFour distinct profiles of remembered parental rearing emerged: two supportive parents, two unsupportive parents, a supportive mother but unsupportive father, and a supportive father but unsupportive mother. Results document the differential effects of these profiles on parenting and other maternal and infant outcomes.ConclusionRemembering two supportive parents confers the most benefit for mothers and their infants.ImplicationsFor mothers with nonsupportive childhood experiences, processing that legacy within a therapeutic relationship may bolster multiple perinatal domains.