bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients
Authors: Ceserani Valentina , Lo Rito Mauro , Agnifili Mauro Luca , Pascaner Ariel F. , Rosato Antonio , Anglese Serena , Deamici Miriam , Negri Jessica , Corrado Chiara , Bedogni Francesco , Secchi Francesco , Lombardi Massimo , Auricchio Ferdinando , Frigiola Alessandro , Conti Michele 
Published: October 2023

AbstractAnomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propose to assess the coronary blood flow (CBF) in AAOCA by computational simulations but they are limited by the use of data from literature retrieved from normal subjects. To overcome this limitation and obtain a reliable assessment of CBF, we developed a fully patient-specific lumped parameter model based on clinical imaging and in-vivo data retrieved during invasive coronary functional assessment of subjects with AAOCA. In such a way, we can estimate the CBF replicating the two hemodynamic conditions in-vivo analyzed. The model can mimic the effective coronary behavior with high accuracy and could be a valuable tool to quantify CBF in AAOCA. It represents the first step required to move toward a future clinical application with the aim of improving patient care. The study was registered at Clinicaltrial.gov with (ID: NCT05159791, date 2021-12-16).
Compliance to iron folic acid supplementation and its associated factors among pregnant women attending Antenatal clinic in Wondo district: a cross-sectional study
Authors: Mengistu Taye , Lencha Bikila , Mekonnen Ashenafi , Degno Sisay , Yohannis Daniel , Beressa Girma 
Published: October 2023

AbstractPregnant women are at high risk for iron deficiency anemia due to increased nutrient requirements during pregnancy. Despite high coverage of iron and folic acid supplementation (IFAS), low compliance is reported. The study aimed to assess compliance with IFAS and its associated factors among antenatal care (ANC) attendees in Wondo District, Southern Ethiopia. A facility-based cross-sectional study was conducted among 400 pregnant women. Pregnant women were selected through systematic random sampling. Pre-tested structured questionnaire was used to collect data through face to face interview. Data were entered into Epi-info and exported to Statistical Package for Social Sciences for analysis. The variables with p-value < 0.25 in the bivariable analysis were entered into the multivariable logistic regression model. P values less than 0.05 were considered significant. Results were reported as crude and adjusted odds ratios with 95% confidence intervals. The prevalence of compliance to IFAS was (177, 44.3%). Factors significantly associated with compliance to IFAS were maternal age ≥ 25 years [AOR 2.27, 95% CI (1.21, 4.28)], maternal education [AOR 2.62, 95% CI (1.43, 4. 79)], husband's education [AOR 3.60, 95% CI (2.07, 6.25)], knowledge of anemia [AOR 4.40, 95% CI (2.65, 7.30)], and knowledge of IFA [AOR 2.21, 95% CI (1.40, 3.50)]. This study showed that compliance to IFAS was low. Maternal age, maternal education, husband's education, knowledge about anemia and iron folic acid was found to be significantly associated with adherence to IFAS. Emphasis should be placed on young, uneducated mothers and their husbands.
A green hydrophobic deep eutectic solvent for extraction of phenol from aqueous phase
Authors: Saien Javad , Bahiraei Mansoureh , Jafari Farnaz 
Published: October 2023

AbstractDeep eutectic solvents (DESs), have been recognized as effective materials for the extraction of different compounds. In this study, the performance of a novel hydrophobic DES was evaluated for the extraction of phenol from aqueous solutions. Octanoic and dodecanoic fatty acid precursors with a definite molar ratio of 3:1, respectively, were used for the DES having a low melting point of 8.3 °C. The purity and stability of the product were confirmed via characterizing by FTIR, 1H and 13C NMR methods. The liquid–liquid equilibrium of the water + phenol + DES ternary system at different temperatures of 293.2, 298.2 and 308.2 K was accordingly studied through cloud point titration method and refractive index measurement. Interestingly, the important parameters of the solute distribution coefficient and the separation factor were, respectively, within the high levels of (6.8321–9.7787) and (895.76–2770.17), indicating the amazing capability of the DES. Reasonably, both of these parameters decreased with temperature. The NRTL and UNIQUAC thermodynamic models were employed to reproduce the obtained tie-lines and to determine the interaction parameters at each temperature. The low level root mean square deviations for the mentioned models were, respectively, within (0.0014–0.0027) and (0.0045–0.0063); confirming satisfactorily agreement with the experimental data.
Characterization and properties of manganese oxide film coated clinoptilolite as filter material in fixed-bed columns for removal of Mn(II) from aqueous solution
Authors: Jin Xing , Fu Jinxiang , Yu Pengfei , Luo Di 
Published: October 2023

AbstractA new filter material, manganese oxide film coated clinoptilolite (MOFCC), was characterized and introduced to explore the effect in treating high concentration of manganese (1.71–2.12 mg L−1) from aqueous solution in fixed-bed column. Adsorption behavior of Mn(II) can be approximately described with the Langmuir isotherm. During the continuous 30 days filtration experiment, the removal rate of Mn(II) has maintained to be above 95.51%, the accumulated removal amount (806.42 mg) is much higher than the theoretical adsorption capacity (89.71 mg), which indicated that the removal of manganese by MOFCC includes both adsorption and auto-catalytic oxidation process, and it does not require a start-up period. SEM, EDS, XPS, XRD, ZETA potential and BET analyses were used to observe the surface properties of MOFCC. The manganese oxide film of MOFCC exhibits in clusters, apparently on occupied surface, the main component of the manganese oxide film is (Na0.7Ca0.3)Mn7O14·2.8H2O, the specific surface area of MOFCC is 38.76 m2 g−1, and the pore size is concentrated in the range of 3–40 nm, within the mesoporous range mesopores. pHpzc (point of zero charge) value is about 2.36. The characteristics of MOFCC make it an excellent manganese removal filter material for water treatment plant. Therefore, there is a long-term practical significance to develop new system for deep removal of manganese based on MOFCC.
The effect of pupil size on the measurement of corneal birefringence properties: preliminary study
Authors: Sobczak Marcelina , Asejczyk Magdalena , Wilczyński Maciej 
Published: October 2023

AbstractWe used a partial Mueller matrix polarimeter to measure the corneal anisotropic properties at three pupil sizes (dilated, natural, and constricted). The geometrical parameters of first order isochromes were described by quadrilaterals. These parameters are statistically significantly different between the three pupil sizes. The pupillary size changes do not influence the azimuth angle distribution α. The retardation R and birefringence distributions show asymmetry in the nasal–temporal cross-section. There are differences between pupil sizes for both nasal and temporal parts of the cornea for these distributions. Iridial light scattering and diffraction might be the reason for these differences.
miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6
Authors: Hong Soon Auck , Lee Sieun , Park Jihye , Hong Mineui , Yoon Jung-Sook , Lee Heejin , Lee Ji Hyun , Kim Seoree , Won Hye Sung , Kang Keunsoo , Ko Yoon Ho , Ahn Young-Ho 
Published: October 2023

AbstractPathological markers that can monitor the progression of gastric cancer (GC) may facilitate the diagnosis and treatment of patients with diffuse GC (DGC). To identify microRNAs (miRNAs) that can differentiate between early and advanced DGC in the gastric mucosa, miRNA expression profiling was performed using the NanoString nCounter method in human DGC tumors. Ectopic expression of miR-199a and miR-199b (miR-199a/b) in SNU601 human GC cells accelerated the growth rate, viability, and motility of cancer cells and increased the tumor volume and weight in a mouse xenograft model. To study their clinicopathological roles in patients with GC, miR-199a/b levels were measured in human GC tumor samples using in situ hybridization. High miR-199a/b expression level was associated with enhanced lymphovascular invasion, advanced T stage, and lymph-node metastasis. Using the 3′-untranslated region (UTR) luciferase assay, Frizzled-6 (FZD6) was confirmed to be a direct target of miR-199a/b in GC cells. siRNA-mediated depletion of FZD6 enhanced the motility of SNU601 cells, and addback of FZD6 restored cancer cell motility stimulated by miR-199a/b. In conclusion, miR-199a/b promotes DGC progression by targeting FZD6, implying that miR-199a/b can be used as prognostic and diagnostic biomarkers for the disease.
Antimicrobial Fe2O3-CuO-P2O5 glasses
Authors: Mitchell Alexandra L. , Lee Sung Hoon , McEnroe David J. , Null Eric L. , Sternquist Daniel A. , Hufziger Kathryn A. , Rice Brian J. , Scrimshire Alex , Bingham Paul A. , Gross Timothy M. 
Published: October 2023

AbstractGlasses with high antimicrobial efficacy were developed in the Fe2O3-CuO-P2O5 ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-P2O5 glasses were not durable enough for use as high touch point articles, so Fe2O3 was added to the compositions to increase the chemical durability. The amount of Cu leachate decreased by at least 3 orders of magnitude when Fe2O3 was increased from 0 to 13.1 mol%. At the highest Fe2O3 contents and corresponding highest durability, the glass was no longer able to pass a test of antimicrobial efficacy with < 3 log kill compared to > 5 log kill for all other compositions. Ab-initio molecular dynamics simulations showed increasing bridging oxygen species at the expense of non-bridging oxygen species with the increase in Fe2O3 content, showing that the glasses exhibited increased chemical durability because they were more interconnected and structurally bound. Experimental results with glasses at fixed CuO and decreasing Fe2O3 confirmed that Fe2O3 content (not CuO) controlled the Cu release rate and, thus, the antimicrobial efficacy of the glasses. The significance of the oxidation state of the leached Cu was overwhelmed by the importance of the amount of Cu leachate.
The self-assembly of l-histidine might be the cause of histidinemia
Authors: Ajikumar Ajitha , Premkumar Anakha Kandara Nikarthil , Narayanan Sunilkumar Puthenpurackal 
Published: October 2023

Abstractl-Histidine is an essential amino acid with unique biochemical and physiological properties. Histidinemia is a disease condition caused by the elevated level of l-histidine in our blood. Mutations in the histidase, an enzyme for the breakdown of histidine, is the cause of the rise in histidine concentration. To our knowledge, no research has been done on why a high concentration of histidine causes histidinemia. In this study, we provide a potential explanation why the elevated levels of histidine in the human body causes histidinemia. In this study we have found that l-histidine self-assembled in water to form nano sheet structures at physiological pH and temperature, using 1D 1H NMR spectroscopy, diffusion ordered spectroscopy (DOSY) and scanning electron microscope (SEM) techniques. The kinetics of self-assembly has been studied using real time NMR spectroscopy. We observed that both the aromatic ring and aliphatic part are equally contributing to the self-assembly of l-histidine. The symptoms of histidinemia, neurological deficits and speech delays, are similar to that of the neurodegenerative diseases caused by the self-assembly of peptides and proteins. We speculate that the self-assembly of l-histidine might be the cause of histidinemia.
CEP20 promotes invasion and metastasis of non-small cell lung cancer cells by depolymerizing microtubules
Authors: Feng Sijie , Yuan Shuai , Hou Baohua , Liu Zhiqiang , Xu Yanjun , Hao Shuangying , Lu Yunkun 
Published: October 2023

AbstractWorldwide, Lung cancer is the leading cause of cancer-related death and poses a direct health threat, non-small cell lung cancer (NSCLC) is the most common type. In this study, we demonstrated that centrosomal protein 20 (CEP20) is upregulated in NSCLC tissues and associated with cancer invasion metastasis. Notably, CEP20 depletion inhibited NSCLC cell proliferation, migration, and microtubule polymerization. Mechanistically, we discovered that CEP20 is critical in the development of NSCLC by regulating microtubule dynamics and cell adhesion-related signaling pathways. Furthermore, the knockdown or overexpression of CEP20 affects microtubule polymerization in A549 cell lines. Our research provides a promising therapeutic target for the diagnosis and treatment of lung cancer, as well as a theoretical and experimental basis for clinical application.
Investigation of LGALS2 expression in the TCGA database reveals its clinical relevance in breast cancer immunotherapy and drug resistance
Authors: He Song , Ji Zhonghao , Zhang Qing , Zhang Xiwen , Chen Jian , Hu Jinping , Wang Ruiqing , Ding Yu 
Published: October 2023

AbstractBreast cancer (BRCA) is known as the leading cause of death in women worldwide and has a poor prognosis. Traditional therapeutic strategies such as surgical resection, radiotherapy and chemotherapy can cause adverse reactions such as drug resistance. Immunotherapy, a new treatment approach with fewer side effects and stronger universality, can prolong the survival of BRCA patients and even achieve clinical cure. However, due to population heterogeneity and other reasons, there are still certain factors that limit the efficacy of immunotherapy. Therefore, the importance of finding new tumor immune biomarker cannot be emphasized enough. Studies have reported that LGALS2 was closely related to immunotherapy efficacy, however, it is unclear whether it can act as an immune checkpoint for BRCA immunotherapy. In the current study, changes in LGALS2 expression were analyzed in public datasets such as TCGA-BRCA. We found that LGALS2 expression was associated with immune infiltration, drug resistance and other characteristics of BRCA. Moreover, high LGALS2 expression was closely related to immunotherapy response, and was associated with methylation modifications and clinical resistance for the first time. These findings may help to elucidate the role of LGALS2 in BRCA for the development and clinical application of future immunotherapy strategies against BRCA.
Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
Authors: Zhang Zhijun , Yang Yuan , Hu Changjun , Zhang Zaiqi 
Published: October 2023

AbstractTo further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents of serum SOD, GR, MDA, DNA–protein crosslink (DPC), 8-hydroxydeoxyguanosine (8-OHDG) and DNA adduct were determined by ELISA. The results showed that there were statistically significant differences in the contents of SOD, GR and MDA among the four groups (P < 0.01). The activity of SOD and GR increased along with the increase of pachymaran dosage (SOD: rs = 0.912, P < 0.01; GR: rs = 0.857, P < 0.01), while the content of MDA showing a significant negative correlation (rs = − 0.893, P < 0.01). There were statistically significant differences in the levels of DPC, 8-OHDG and DNA adduct among the four groups (DPC and DNA adduct: P < 0.01, 8-OHDG: P < 0.05), the concentration decreased along with the increase of pachymaran dosage (DPC: rs = − 0.855, P < 0.01; 8-OHDG:rs = − 0.412, P < 0.05, DNA adduct: γs = − 0.869, P < 0.01). It can be inferred that pachymaran can inhibit oxidative stress and DNA damage induced by formaldehyde with the dose–effect relationship.
Study on the influence of reverse faulting on deformation of foundation pit retaining piles
Authors: Niu Yungang , Wang Qiongyi , Ma Fenghai 
Published: October 2023

AbstractThe mechanical properties of soil in fault-fracture zone areas are diverse and complex. Deep excavation projects often encounter adverse geological conditions such as reverse faulting, which can lead to surface subsidence and collapses, posing significant challenges to excavation safety. Currently, there is limited research in the field of deep excavation engineering that analyzes the influence of reverse faulting on the deformation of retaining piles, and the existing research methods are not systematic enough. Therefore, this study aims to investigate the characteristics of how reverse faulting affects the deformation of retaining piles in deep excavation projects. Various research methods were employed, including numerical simulation, on-site monitoring, and orthogonal experiments, using a deep excavation project in Shenzhen as a case study. The results of the study indicate that reverse faulting exacerbates the deformation of retaining piles, causing the trend of increased deformation to shift upward. The upper part of the pile is significantly more affected than the lower part, and the overall deformation of the pile exhibits an approximate spoon-shaped curve distribution, with the maximum deformation occurring in the upper-middle section of the excavation. Under the influence of reverse faulting, the deformation of retaining piles is positively correlated with fault slip distance and fault dip angle, while it is negatively correlated with fault position. The growth rate of the maximum deformation of retaining piles, denoted as r(ΔZmax/Δ), increases approximately logarithmically with increasing fault slip distance and exponentially with increasing fault dip angle, but decreases approximately logarithmically with increasing distance from the fault to the excavation. An analysis of the sensitivity of fault slip distance, fault dip angle, and fault position to the maximum deformation of retaining piles was conducted. It was determined that the fault dip angle has the highest sensitivity, followed by fault slip distance, while fault position has the lowest sensitivity. Based on the fitting of 64 sets of orthogonal experimental data, a good linear relationship was established between the maximum deformation of retaining piles (Uhm) and the indicator η($$\theta \pi T/180^{^\circ } S$$

θ
π
T
/

180

∘

S

), leading to the development of a predictive model for the maximum deformation of retaining piles under the influence of reverse faulting. These research findings provide valuable insights and references for similar engineering projects.
Library of single-etch silicon nitride grating couplers for low-loss and fabrication-robust fiber-chip interconnection
Authors: Korček Radovan , Medina Quiroz David , Wilmart Quentin , Edmond Samson , Cheben Pavel , Vivien Laurent , Alonso-Ramos Carlos , Benedikovič Daniel 
Published: October 2023

AbstractSilicon nitride (Si3N4) waveguides become an appealing choice to realize complex photonic integrated circuits for applications in telecom/datacom transceivers, sensing, and quantum information sciences. However, compared to high-index-contrast silicon-on-insulator platform, the index difference between the Si3N4 waveguide core and its claddings is more moderate, which adversely affects the development of vertical grating-coupled optical interfaces. Si3N4 grating couplers suffer from the reduced strength, therefore it is more challenging to radiate all the waveguide power out of the grating within a beam size that is comparable to the mode field diameter of standard optical fibers. In this work, we present, by design and experiments, a library of low-loss and fabrication-tolerant surface grating couplers, operating at 1.55 μm wavelength range and standard SMF-28 fiber. Our designs are fabricated on 400 nm Si3N4 platform using single-etch fabrication and foundry-compatible low-pressure chemical vapor deposition wafers. Experimentally, the peak coupling loss of − 4.4 dB and − 3.9 dB are measured for uniform couplers, while apodized grating couplers yield fiber-chip coupling loss of − 2.9 dB, without the use of bottom mirrors, additional overlays, and multi-layered grating arrangements. Beside the single-hero demonstrations, over 130 grating couplers were realized and tested, showing an excellent agreement with finite difference time domain designs and fabrication-robust performance. Demonstrated grating couplers are promising for Si3N4 photonic chip prototyping by using standard optical fibers, leveraging low-cost and foundry-compatible fabrication technologies, essential for stable and reproducible large-volume device development.
Rapid detection of vaccinia virus using biofunctionalized fiber-optic ball-tip biosensors
Authors: Rakhimbekova Aida , Kudaibergenov Baizak , Seitkamal Kuanysh , Bellone Aurora , Dauletova Ayazhan , Sypabekova Marzhan , Olivero Massimo , Perrone Guido , Radaelli Antonia , Zanotto Carlo , De Giuli Morghen Carlo , Vangelista Luca , Tosi Daniele 
Published: October 2023

AbstractIn this work, we present the development and biofunctionalization of a fiber-optic ball-resonator biosensor for the real-time detection of vaccinia poxvirus. We fabricated several ball-tip resonators, functionalized through a silanization process to immobilize two bioreceptors: the monoclonal anti-L1R antibody targeting the L1R protein, and the polyclonal rabbit serum antibodies targeting the whole vaccinia virus (VV) pathogen. Experimental measurements were carried out to detect VV in concentrations from 103 to 108 plaque-forming units (PFU), with a limit of detection of around 1.7–4.3 × 103 PFU and a log-quadratic pattern, with a response up to 5 × 10−4 RIU (refractive index units). The specificity was assessed against herpes simplex virus, used as a non-specific control, with the best results obtained with anti-L1R monoclonal antibodies, and through the detection of vaccinia virus/herpes simplex-1 combination. The obtained results provide a real-time viral recognition with a label-free sensing platform, having rapid response and ease of manufacturing, and paving the road to the seamless detection of poxviruses affecting different human and animal species using optical fibers.