bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation
Authors: Tobiasz Joanna , Al-Harbi Najla , Bin Judia Sara , Majid Wakil Salma , Polanska Joanna , Alsbeih Ghazi 
Published: October 2023

IntroductionThe search for biomarkers to predict radiosensitivity is important not only to individualize radiotherapy of cancer patients but also to forecast radiation exposure risks. The aim of this study was to devise a machine-learning method to stratify radiosensitivity and to investigate its association with genome-wide copy number variations (CNVs) as markers of sensitivity to ionizing radiation.MethodsWe used the Affymetrix CytoScan HD microarrays to survey common CNVs in 129 fibroblast cell strains. Radiosensitivity was measured by the surviving fraction at 2 Gy (SF2). We applied a dynamic programming (DP) algorithm to create a piecewise (segmented) multivariate linear regression model predicting SF2 and to identify SF2 segment-related distinctive CNVs.ResultsSF2 ranged between 0.1384 and 0.4860 (mean=0.3273 The DP algorithm provided optimal segmentation by defining batches of radio-sensitive (RS), normally-sensitive (NS), and radio-resistant (RR) responders. The weighted mean relative errors (MRE) decreased with increasing the segments' number. The borders of the utmost segments have stabilized after partitioning SF2 into 5 subranges.DiscussionThe 5-segment model associated C-3SFBP marker with the most-RS and C-7IUVU marker with the most-RR cell strains. Both markers were mapped to gene regions (MCC and SLC1A6, respectively). In addition, C-3SFBP marker is also located in enhancer and multiple binding motifs. Moreover, for most CNVs significantly correlated with SF2, the radiosensitivity increased with the copy-number decrease.In conclusion, the DP-based piecewise multivariate linear regression method helps narrow the set of CNV markers from the whole radiosensitivity range to the smaller intervals of interest. Notably, SF2 partitioning not only improves the SF2 estimation but also provides distinctive markers. Ultimately, segment-related markers can be used, potentially with tissues’ specific factors or other clinical data, to identify radiotherapy patients who are most RS and require reduced doses to avoid complications and the most RR eligible for dose escalation to improve outcomes.
Temporal changes in treatment patterns by age group and functional status before and after PD-1/L1 inhibitor approvals in advanced urothelial carcinoma
Authors: Doshi Gurjyot K. , Li Haojie , Burcu Mehmet , Annavarapu Srinivas , Wells Karen , Imai Kentaro , Moreno Blanca Homet , Singhal Puneet , Mamtani Ronac 
Published: October 2023

IntroductionMetastatic urothelial carcinoma (mUC) has poor prognosis. A high unmet need exists for novel treatment for those who are unfit for platinum-based chemotherapy.MethodsWe aimed to describe real-world temporal changes in patient characteristics and 1L treatment selection for mUC patients in the United States following the approval of anti-PD-1/L1 treatments. This study was a retrospective, observational study using anonymized and structured oncology electronic medical record (EMR) data from IQVIA and the US Oncology Network iKnowMed (USON).ResultsAfter approval of 1L anti-PD-1/L1 treatment for mUC, there is a marked increase in the use of 1L anti-PD-1/L1 monotherapies, accompanied by a proportional decrease in 1L platinum-based treatments and non-guideline-based therapy; particularly among the elderly (&gt; 75 years) and those with poor ECOG performance status (ECOG PS 2+).DiscussionAnti-PD-1/L1 monotherapies fulfill the prior unmet need of frail mUC patients who are ineligible for platinum-based therapies.
Impact of virtual reality on pain management in transrectal MRI-guided prostate biopsy
Authors: Perenic Emma , Grember Emilie , Bassard Sébastien , Koutlidis Nicolas 
Published: October 2023

BackgroundThe beneficial effect of virtual reality (VR) on pain management in the context of transrectal MRI-guided prostate biopsy is not well established. However, it remains unclear whether an adjunctive of VR also improves pain management. This study aimed to evaluate the impact of VR as adjunctive in pain management in transrectal MRI-guided prostate biopsy (PB).MethodsWe retrospectively evaluated the pain intensity incidence in the 153 patients with PB indication (of which 102 were naïve of PB) who were admitted to our hospital since the acquisition of the Healthy Mind virtual reality headset on 19 January 2021.ResultsBaseline characteristics of patients who received local anesthesia with 1% lidocaine periprostatic nerve block (PPNB) (Group SOC, N = 78) and patients who received VR associated with PPNB (Group VR, N = 75) were largely similar. One PB with general anesthesia was excluded. The mean pain score at day zero was respectively 3.4 (±2.5) and 2.9 (±2.3) for SOC and VR (p = 0.203). However, the mean pain score at day zero was significantly lower in naïve PB patients with VR [2.7 (±2.0)] than in naïve PB patients with SOC [3.8 (±2.5), p = 0.012] when patients were stratified in PB status. Similar results were found on day 3 for the analysis including naïve-PB patients with SOC vs. with VR [0.4 (±2.5) vs. 0.2 (±2.0); p = 0.023)].ConclusionsThe pain intensity was significantly lower in naïve PB patients with VR than in naïve PB patients with SOC. There were no side effects from VR and tolerability was excellent.
Real-world experience with CLAIRYG® 50 mg/mL (intravenous immunoglobulin) in children under 12 years with primary immunodeficiency or immmune thrombocytopenia: a post-approval safety study
Authors: Mahlaoui Nizar , Fouyssac Fanny , Mazingue Françoise , Mallebranche Coralie , Barthez-Toullec Malika , Denti Lamia , Ruhier Kalaivani , André-Bonnet Marie-Hélène , Marie-Cardine Aude , Aladjidi Nathalie , Stephan Jean-Louis 
Published: October 2023

IntroductionThis study presents the results of a real-life, multicenter, prospective, post-approval safety evaluation of Clairyg® 50 mg/mL, a 5% intravenous immunoglobulin (IVIg) liquid, in 59 children (aged &lt; 12 years) with primary immunodeficiency diseases (PID) (n = 32) or immune thrombocytopenia (ITP) (n = 27) in France.MethodsThe primary objective of the study was to assess the safety and tolerability of Clairyg®, recording all serious and non-serious adverse events (AEs), whether related (rAEs) or not related to the product. Secondary objectives aimed at evaluating the administration of Clairyg® under routine conditions and the available efficacy data to better document the benefit/risk ratio in this pediatric population. An exploratory objective was added to evaluate the potential factors associated with the occurrence of rAEs. Patients received Clairyg® according to the approved dosage under normal conditions of prescriptions over a median follow-up period of 11.8 months.ResultsA total of 549 infusions (PID: n = 464 and ITP: n = 85), were administered, of which 58.8% were preceded by premedication. The most frequent rAEs were headache, vomiting, and pyrexia in both indications. Most of them were considered non-serious and mild or moderate in intensity. A severe single rAE was observed (aseptic meningitis) in a 4-year-old girl presenting with chronic ITP. The exploratory multivariate analysis of potential co-factors showed that the occurrence of rAEs is significantly linked to high IVIg doses and possibly to female gender. The annualized rate of serious bacterial infections was 0.11 for patients with PID. For patients with ITP, 74.1% experienced at least one bleeding episode during the follow-up, mostly a cutaneous one, and none had gastrointestinal, genitourinary, or central nervous system bleeding.ConclusionClairyg® was well tolerated and allowed for control of serious bacterial infection in PID and serious bleeding in ITP, which are the main complications in these respective pediatric disorders. No new safety signal was detected in children less than 12 years-old in real-life conditions of use.
Evaluating clinical pharmacists’ involvement in postoperative acute pain services: a multicenter survey in Guangdong Province, China
Authors: Lu Junxiong , Chen Mingzhen , He Guansheng , Chen Binwei , Wang Ruolun 
Published: October 2023

Objective: Postoperative pain management is an important part of surgical pharmacy. Postoperative acute pain services in China are in their initial stages. This survey aimed to investigate the attitudes, involvement, and knowledge of clinical pharmacists in China regarding postoperative acute pain services. The results can provide valuable information to guide clinical pharmacists in developing targeted strategies to improve their postoperative acute pain service capabilities.Methods: A questionnaire was distributed to the pharmacy departments of 133 grade A tertiary hospitals in Guangdong province, and the responses were collected electronically.Results: 123 completed questionnaires were collected from clinical pharmacists. Although 95.93% of clinical pharmacists believed they should participate in postoperative pain services, only 62.6% reported substantial involvement. Overall satisfaction with the postoperative pain service was 93.5%. Understanding of non-steroidal anti-inflammatory drugs and opioid analgesics by clinical pharmacists was comparable (p &gt; 0.05). Furthermore, 98.37% of clinical pharmacists desired systematic learning in postoperative pain management, and 40.65% expressed a strong need.Conclusion: Clinical pharmacists in China demonstrate a positive attitude toward participating in postoperative acute pain services. However, the actual level of involvement was concerning, and the lack of systematic training and well-established work protocols may be contributing factors. Efforts should be made to establish comprehensive and standardized processes and work protocols for postoperative acute pain services and provide systematic and hierarchical professional training to enhance clinical pharmacists’ capabilities in postoperative acute pain services.
To respond or not to respond: exploring empathy-related psychological and structural brain differences between placebo analgesia responders and non-responders
Authors: Hartmann Helena , Banwinkler Magdalena , Riva Federica , Lamm Claus 
Published: October 2023

IntroductionPlacebo responsiveness is highly variable across individuals. In the domain of pain, it may range from pronounced hypoalgesia to no response at all. Which factors predict such variation awaits clarification, as the available literature is characterized by mixed and inconclusive results. Particularly interesting in this case are social factors such as empathy or prosocial behavior, as prior work has stressed the connection between feeling pain yourself and empathizing with pain observed in others.MethodsIn a mixed confirmatory and exploratory approach, this study investigated potential psychological and structural brain differences between placebo responders and non-responders in the domain of pain. We aggregated data of four behavioral and neuroimaging studies that had been designed to investigate the effects of placebo analgesia on empathy.ResultsAnalyses comparing groups of placebo responders and non-responders showed significant group differences in trait characteristics, with responders reporting increased helping behavior and lower psychopathic traits compared to non-responders. Uncorrected results further showed higher pain-related empathic concern in responders vs. non-responders. These results were accompaniedby tentative group differences in brain structure: placebo analgesia non-responders exhibited increased gray matter volume in left inferior temporal and parietal supramarginal cortical areas, and an increased cortical surface area in bilateral middle temporal cortex.DiscussionTogether, our findings suggest that modifiability of one’s pain perception by means of placebo effects is linked to personality traits characterizing social emotions and behavior. They also hint that these psychological as well as brain structural characteristics might be beneficial for the identification of placebo responders. At the same time, they stress the importance of considering contextual factors such as the study setting or paradigm when investigating the association between individual characteristics and placebo responding.
Prevalence of Foodborne Bacterial Pathogens and Antibiotic Resistance Genes in Sweets from Local Markets in Iran
Authors: Pakbin Babak , Amani Zahra , Rahimi Zahra , Najafi Somayeh , Familsatarian Behnaz , Khakpoor Alireza , Brück Wolfram Manuel , Brück Thomas B. 
Published: October 2023

Background: This study aimed to investigate the prevalences of some important antibiotic-resistance genes (ARGs) and foodborne bacterial pathogens in sweet samples collected from local markets in Iran. Methods: Forty sweet samples were collected. Foodborne pathogens and ARGs were detected in the sweet samples by conventional and multiplex PCR assays using species-specific primers. Results: Staphylococcus aureus, Cronobacter sakazakii, Shigella spp., Campylobacter jejuni, and Campylobacter coli were detected and identified in 47.5%, 20%, 45%, 5%, and 30% of the sweet samples, respectively. We found S. aureus and Shigella spp. were the most prevalent bacterial pathogens. S. aureus was found to be the most frequent pathogenic bacteria profiled in these samples. We also found a significant correlation between the presence of C. coli and Cr. sakazakii. We detected the blaSHV resistance gene in 97.5% of the sweet samples; however, blaTEM was detected in only one sample (2.5%). Conclusions: Regarding these results, we suggest preventive strategies such as implementing automation of food processing; monitoring the personal hygiene and health of food handlers, and testing regularly for antibiotic resistance in raw materials and products.
New Monotonicity and Infinite Divisibility Properties for the Mittag-Leffler Function and for Stable Distributions
Authors: Altaymani Nuha , Jedidi Wissem 
Published: October 2023

Hyperbolic complete monotonicity property (HCM) is a way to check if a distribution is a generalized gamma (GGC), hence is infinitely divisible. In this work, we illustrate to which extent the Mittag-Leffler functions Eα,α∈(0,2], enjoy the HCM property, and then intervene deeply in the probabilistic context. We prove that for suitable α and complex numbers z, the real and imaginary part of the functions x↦Eαzx, are tightly linked to the stable distributions and to the generalized Cauchy kernel.
Study on Residence Time Distribution of Particles in a Quasi-Two-Dimensional Batch Discharge Silo Using the Multi-Simulation Averaging Method
Authors: Zhu Jingzhen , Xu Wentao , Zheng Rongyao , Wang Can , Li Xiwen 
Published: October 2023

As the primary carrier for storing and transporting particles, the silo is widely used in the production process. The RTD is a promising method for studying the silo discharge process and has not been studied enough. This paper presents a study on the residence time distribution (RTD) and flow pattern of particles in a two-dimensional flat-bottom batch discharge silo under gravity using experiments and the discrete element method (DEM). Meanwhile, a multi-simulation averaging method is proposed to eliminate local fluctuations in the residence time. The results are as follows. The mean flow rate is 16.85 g·s−1 in simulations, which is only 2.7% larger than the experimental value. In the central area of the silo, the residence time contour lines take on elliptical shapes and the trajectories of particles are straight lines. The particles are distributed along the elliptical residence time contour lines all the time during the discharge process until they flow out of the silo. The particles near the side wall of the silo swiftly flow with a constant acceleration to the central line of the silo along the upper horizontal surface, which has become avalanche slopes, and then flow down the outlet together with the particles in the radial flow region. In this study, an elliptical distribution law during the silo discharge process was funded for the first time. An improved radial flow model was proposed with a higher accuracy and clearer physical meaning, which will be helpful in silo design and scaling up in industrial applications.
Effectiveness and safety of asynchronous telemedicine consultations in general practice: a systematic review
Authors: Leighton Cara , Cooper Alison , Porter Annavittoria , Edwards Adrian , Joseph-Williams Natalie 
Published: October 2023

BackgroundThere is a focus on increasing asynchronous telemedicine use, which allows medical data to be transmitted, stored, and interpreted later; however, limited evidence of the quality of care it allows in general practice hinders its use.AimTo investigate uses and effectiveness of asynchronous telemedicine in general practice, according to the domains of healthcare quality, and describe how the COVID-19 pandemic changed its use.Design & settingSystematic review in general practice.MethodA systematic search was carried out across four databases using terms related to general practice, asynchronous telemedicine, uses, and effectiveness, and supported by citation searching. This was followed by screening according to pre-defined criteria, data extraction, and critical appraisal. Narrative synthesis was then undertaken guided by the six domains of healthcare quality and exploring differences in use before and following the COVID-19 pandemic.ResultsSearches yielded 6864 reports; 27 reports from 23 studies were included. Asynchronous telemedicine is used by a range of staff and patients across many countries. Safety and equity are poorly reported but there were no major safety concerns. Evidence from other domains of healthcare quality show effectiveness in making diagnoses, prescribing medications, replacing other consultations, providing timely care, and increased convenience for patients. Efficiency is impacted by negative effects on workflow, through poor implementation and patient non-adherence, limiting usability and requiring new administrative approaches from healthcare staff. Asynchronous telemedicine use increased rapidly from March 2020, following the COVID-19 pandemic outbreak.ConclusionAsynchronous telemedicine provides quality care for patients but is limited by reports of increased workload and inefficient workflow compared with face-to-face consultations. Limits of evidence include heterogeneity and small-scale studies. Further research into cost-effectiveness, equity, safety, and sustained implementation will influence future policy and practice.
Fabrication of V1−x
Ti
x
O2 microbolometers on Si3N4/SiO2 membranes
Authors: Van Nhu Hai , Kawahara Masami , Samura Tsuyoshi , Tachiki Takashi 
Published: October 2023

Abstract
V1−x
Ti
x
O2 thin films have been prepared on Si3N4/SiO2/Si substrates by the two-step process of (1) growth of VO2/TiO2 thin films by metal-organic decomposition with carbothermal reduction, and (2) the interdiffusion between V and Ti atoms at the interface between the VO2 and TiO2 thin films during the growth of the VO2 thin film. The abrupt resistance change and the thermal hysteresis due to the metal-insulator transition were gradually suppressed with increasing the firing temperature, and they completely disappeared for the V0.65Ti0.35O2 thin film prepared at 650 °C. A relatively high TCR of −4.2%/K was obtained from the film over a wide temperature range of 20 °C–90 °C. V0.65Ti0.35O2 microbolometers with a size of 5 μm × 15 μm were fabricated by photolithography and Ar ion milling, and a Si3N4/SiO2 membrane under the microbolometer was formed with an aqueous KOH solution. The DC sensitivity of the fabricated microbolometer on the membrane was estimated to be 9876 W−1 and 20 times higher than that of the microbolometer on the Si3N4/SiO2/Si substrate. The V0.65Ti0.35O2 microbolometer on the membrane is available for a terahertz detector operating over the wide temperature range.
Silicon nanocrystals produced by adiabatic expansion of silicon vapor: emergence of body-centered cubic silicon nanocrystals
Authors: Sato Seiichi , Kimura Kenta , Osuna Koshiro 
Published: October 2023

Abstract
Silicon (Si) nanocrystals with diameters of 2–5 nm were produced through non-equilibrium condensation of Si vapor. Electron diffraction analysis indicated that the nanocrystals formed a bcc structure with eight atoms per primitive cell (BC-8). The optical bandgap energy of the nanocrystals was about 1.6 eV, and photoluminescence was observed in the region of the bandgap energy. The obtained energy is compared with a theoretically predicted value of the BC-8 Si crystal of the present size.
Evaluations of ethylene glycol and polyethylene glycol aqueous solutions using a hybrid sensor of surface plasmon resonance and quartz crystal microbalance
Authors: Katakura Shuta , Tsujisawa Yuto , Ohdaira Yasuo , Baba Akira , Kato Keizo , Shinbo Kazunari 
Published: October 2023

Abstract
A hybrid sensor based on surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) was prepared. One of the electrodes of the QCM sensor had a grating structure to enable SPR excitation. The SPR property was investigated through the transmission of the visible-light spectrum. The theoretical calculation showed that the experimental values almost corresponded to the theoretical ones; this suggests that the transmitted light dips were due to SPR. In order to investigate the usefulness of this hybrid sensor, the characteristics of SPR and the oscillation frequency drops of QCM (ΔF
QCM) were investigated for aqueous solutions of ethylene glycol and polyethylene glycols with various degrees of polymerization. The position and slope of the SPR dip wavelength and the ΔF
QCM curves depended on the degree of polymerization, suggesting that the sensor can be used to evaluate a solution property and/or discriminate a solute material.
Upconversion emission using the interfacial charge transfer state
Authors: Izawa Seiichiro 
Published: October 2023

Abstract
Triplet–triplet annihilation (TTA) is the upconversion process in which one high-energy singlet exciton is created from two low-energy triplet excitons. TTA is widely utilized in the field of organic optoelectronics because it can emit light at almost twice the energy of the initial excited state. TTA is a two-photon process, thus the spatial density of triplet excitons must be large for efficient TTA. By sensitizing the triplet excitons of the emitter molecule using charge transfer (CT) states at the interface, we achieved highly efficient TTA emission in solid-state photon upconversion systems and organic LED devices with an ultralow driving voltage. This is attributed to the location and high concentration near the D/A interface of the triplet exciton sensitized by the CT state, responsible for the efficient concentration-dependent TTA process. This report explains the properties of CT states and introduces recent results related to TTA.
1.2 kV SiC MOSFETs with tapered buffer oxide for the suppression of the electric field crowding effect
Authors: Yoon Hyowon , Kim Jinhun , Kim Sangyeob , Kim Chaeyun , Park Yeongeun , Kwon Soontak , Song Jaejin , Lee Jeongyun , Ha Min-Woo , Seok Ogyun 
Published: October 2023

Abstract
1.2 kV silicon carbide (SiC) MOSFETs with buffered oxide, which have been developed to reduce the gate–drain charge (Q
GD), have the problem that the electric field is crowded at the corners of the buffered oxide. In this paper, 1.2 kV SiC MOSFETs with tapered buffer oxide are proposed to suppress the electric field crowding effect. The devices with tapered buffer oxide having an angle of 40° demonstrate a maximum electric field at the gate oxide in the off-state (E
ox,max) of 1.87 MV·cm−1, achieving a 13.4% reduction compared to devices with a conventional structure. Additionally, it is verified that the output characteristics of 1.2 kV SiC MOSFETs can be improved by applying tapered buffer oxide. This is because the junction FET region can be designed with high concentration through the suppression of the electric field of the tapered buffer oxide.