bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precise Ink Drawing of 3D Models
Authors: Sousa Mario Costa , Foster Kevin , Wyvill Brian , Samavati Faramarz 
Published: November 2003

Abstract Drawings made with precise pen strokes accurately reveal the geometric forms that give subjects their characteristicshape. We present a system for non‐photorealistic rendering of precise drawing strokes over dense 3Dtriangle meshes with arbitrary topology. During an automatic pre‐process, we construct an extended version ofthe edge‐buffer data structure to allow the calculation of shape measures at each mesh edge, by adapting numericalmethods used in geomorphology. At runtime, feature edges related to shape measures are extracted andrendered as strokes with varying thickness and pen marking styles. Stroke thickness is automatically adjusted byconsidering surface curvature. Pen marking styles and visual effects of ink distribution are both controlled by theuser. We demonstrate precise drawing strokes over complex meshes revealing a variety of shape characteristics.
Multiresolution Surface Representation Based on Displacement Volumes
Authors: Botsch Mario , Kobbelt Leif 
Published: November 2003

Abstract We propose a new representation for multiresolution models which uses volume elements enclosed between thedifferent resolution levels to encode the detail information. Keeping these displacement volumes locally constantduring a deformation of the base surface leads to a natural behaviour of the detail features. The correspondingreconstruction operator can be implemented efficiently by a hierarchical iterative relaxation scheme, providingclose to interactive response times for moderately complex models. Based on this representation we implement a multiresolution editing tool for irregular polygon meshes that allowsthe designer to freely edit the base surface of a multiresolution model without having to care about self‐intersectionsin the respective detailed surface. We demonstrate the effectiveness and robustness of the reconstructionby several examples with real‐world data.
Progressive Simplification of Tetrahedral Meshes Preserving All Isosurface Topologies
Authors: Chiang Yi‐Jen , Lu Xiang 
Published: November 2003

Abstract In this paper, we propose a novel technique for constructing multiple levels of a tetrahedral volume dataset whilepreserving the topologies of all isosurfaces embedded in the data. Our simplification technique has two majorphases. In the segmentation phase, we segment the volume data into topological‐equivalence regions, that is, thesub‐volumes within each of which all isosurfaces have the same topology. In the simplification phase, we simplifyeach topological‐equivalence region independently, one by one, by collapsing edges from the smallest to the largesterrors (within the user‐specified error tolerance, for a given error metrics), and ensure that we do not collapseedges that may cause an isosurface‐topology change. We also avoid creating a tetrahedral cell of negative volume(i.e., avoid the fold‐over problem). In this way, we guarantee to preserve all isosurface topologies in the entiresimplification process, with a controlled geometric error bound. Our method also involves several additionalnovel ideas, including using the Morse theory and the implicit fully augmented contour tree, identifying typesof edges that are not allowed to be collapsed, and developing efficient techniques to avoid many unnecessary orexpensive checkings, all in an integrated manner. The experiments show that all the resulting isosurfaces preservethe topologies, and have good accuracies in their geometric shapes. Moreover, we obtain nice data‐reductionrates, with competitively fast running times.
BDAM — Batched Dynamic Adaptive Meshes for High Performance Terrain Visualization
Authors: Cignoni P. , Ganovelli F. , Gobbetti E. , Marton F. , Ponchio F. , Scopigno R. 
Published: November 2003

Abstract This paper describes an efficient technique for out‐of‐core rendering and management of large textured terrainsurfaces. The technique, called Batched Dynamic Adaptive Meshes (BDAM), is based on a paired tree structure:a tiled quadtree for texture data and a pair of bintrees of small triangular patches for the geometry. These smallpatches are TINs and are constructed and optimized off‐line with high quality simplification and tristrippingalgorithms. Hierarchical view frustum culling and view‐dependent texture and geometry refinement is performedat each frame through a stateless traversal algorithm. Thanks to the batched CPU/GPU communication model,the proposed technique is not processor intensive and fully harnesses the power of current graphics hardware.Both preprocessing and rendering exploit out‐of‐core techniques to be fully scalable and to manage large terraindatasets. Categories and Subject Descriptors (according to ACM CCS): I.3.3 [Computer Graphics]: Picture and Image Generation;I.3.7 [Computer Graphics]: Three‐Dimensional Graphics and Realism.
Beyond Stippling  — Methods for Distributing Objects on the Plane
Authors: Hiller Stefan , Hellwig Heino , Deussen Oliver 
Published: November 2003

Abstract Conventionally, stippling is an effective technique for representing surfaces in pen‐and‐ink. We present new efficientmethods for stipple drawings by computer. In contrast to already existing techniques, arbitrary shapes canbe used in place of dots. An extension of Lloyd's Method enables us to position small objects on a plane in a visuallypleasing form. This allows us to generate new illustration styles. Similar methods can be used for positioningobjects in other applications.
Reanimating Faces in Images and Video
Authors: Blanz V. , Basso C. , Poggio T. , Vetter T. 
Published: November 2003

Abstract This paper presents a method for photo‐realistic animation that can be applied to any face shown in a single imageor a video. The technique does not require example data of the person's mouth movements, and the image to beanimated is not restricted in pose or illumination. Video reanimation allows for head rotations and speech in theoriginal sequence, but neither of these motions is required. In order to animate novel faces, the system transfers mouth movements and expressions across individuals, basedon a common representation of different faces and facial expressions in a vector space of 3D shapes and textures.This space is computed from 3D scans of neutral faces, and scans of facial expressions. The 3D model's versatility with respect to pose and illumination is conveyed to photo‐realistic image and videoprocessing by a framework of analysis and synthesis algorithms: The system automatically estimates 3D shape andall relevant rendering parameters, such as pose, from single images. In video, head pose and mouth movements aretracked automatically. Reanimated with new mouth movements, the 3D face is rendered into the original images. Categories and Subject Descriptors (according to ACM CCS): I.3.7 [Computer Graphics]: Animation
Advanced Design for a Realistic Virtual Brush
Authors: Xu Songhua , Lau Francis C.M. , Tang Feng , Pan Yunhe 
Published: November 2003

Abstract This paper proposes a novel algorithmic framework for an advanced virtual brush to be used in interactive digitalpainting. The framework comprises the following components: a geometry model of the brush using a hierarchicalrepresentation that leads to substantial savings in every step of the painting process; fast online brush motionsimulation assisted by offline calibration that guarantees an accurate and stable simulation of the brush's dynamicbehavior; a new pigment model based on a diffusion process of random molecules that considers delicateand complex pigment behavior at dipping time as well as during painting; and a user‐adaptation component thatenables the system to cater for the personal painting habits of different users. A prototype system has been implementedbased on this framework. Compared with other virtual brushes, this new system is designed to presenta realistic brush in the sense that the system accurately and stably simulates the complex painting functionalityof a running brush, and therefore is capable of creating high‐quality digital paintings with minute aesthetic detailsthat can rival the real artwork. The advanced features also give rise to a high degree of expressiveness ofthe virtual brush that the user can comfortably manipulate. http://www.csis.hku.hk/songhuale‐brush/ providessupplementary materials for this paper. Categories and Subject Descriptors (according to ACM CCS): I.3.6 [Methodology and Techniques]: Interactiontechniques; I.3.5 [Computational Geometry and Object Modeling]: Physically based modeling; I.3.4 [GraphicsUtilities]: Paint systems;
Sound in ecclesiastical spaces in Cordoba. Architectural projects incorporating acoustic methodology (El sonido del espacio eclesial en Cordoba. El proyecto arquitectonico como procedimiento acustico)
Authors: Suarez Rafael 
Published: November 2003

This thesis is concerned with the acoustic analysis of ecclesiastical spaces, and the subsequent implementation of acoustic design methodology in architectural renovations. One begins with an adequate architectural design of specific elements (shape, materials, and textures), with the intention of elimination of acoustic deficiencies that are common in such spaces. These are those deficiencies that impair good speech intelligibility and good musical audibility. The investigation is limited to churches in the province of Cordoba and to churches built after the reconquest of Spain (1236) and up until the 18th century. Selected churches are those that have undergone architectural renovations to adapt them to new uses or to make them more suitable for liturgical use. The thesis attempts to summarize the acoustic analyses and the acoustical solutions that have been implemented. The results are presented in a manner that should be useful for the adoption of a model for the functional renovation of ecclesiastical spaces. Such would allow those involved in architectural projects to specify the nature of the sound, even though somewhat intangible, within the ecclesiastical space.
Thesis advisors: Jaime Navarro and Juan J. Sendra Copies of this thesis written in Spanish may be obtained by contacting the advisor, Jaime Navarro, E.T.S. de Arquitectura de Sevilla, Dpto. de Construcciones Arquitectonicas I, Av. Reina Mercedes, 2, 41012 Sevilla, Spain. E-mail address: jnavarro@us.es
Architectural acoustics and the heritage of theater architecture in Andalusia (Acustica arquitectonica y patrimonio teatral en Andalucia)
Authors: Leon Angel Luis 
Published: November 2003

This thesis reports on the study of the acoustic properties of 18 theaters belonging to the Andalusian historical and architectural heritage. These theaters have undergone recent renovations to modernize and equip them appropriately. Coincident with this work, evaluations and qualification assessments with regard to their acoustic properties have been carried out for the individual theaters and for the group as a whole. Data measurements for this purpose consisted of acoustic measurements in situ, both before the renovation and after the renovation. These results have been compared with computer simulations of sound fields. Variables and parameters considered include the following: reverberation time, rapid speech transition index, back-ground noise, definition, clarity, strength, lateral efficiency, interaural cross-correlation coefficient, volume/seat ratio, volume/audience-area ratio. Based on the measurements and analysis, general conclusions are given in regard to the acoustic performance of theaters whose typology and size are comparable to those that were used in this study (between 800 and 8000 cubic meters). It is noted that these properties are comparable to those of the majority of European theaters. The results and conclusions are presented so that they should be of interest to architectural acoustics practitioners and to architects who are involved in the planning of renovation projects for theaters.
Thesis advisors: Juan J. Sendra and Jaime Navarro Copies of this thesis written in Spanish may be obtained by contacting the author, Angel L. Leon, E.T.S. de Arquitectura de Sevilla, Dpto. de Construcciones Arquitectonicas I, Av. Reina Mercedes, 2, 41012 Sevilla, Spain. E-mail address: leonr@us.es
Mycothiol Is Essential for Growth ofMycobacterium tuberculosisErdman
Authors: Sareen Dipti , Newton Gerald L. , Fahey Robert C. , Buchmeier Nancy A. 
Published: November 2003

ABSTRACTMycothiol (MSH) is the major low-molecular-mass thiol in mycobacteria and is associated with the protection ofMycobacterium tuberculosisfrom toxic oxidants and antibiotics. The biosynthesis of MSH is a multistep process, with the enzymatic reaction designated MshC being the ligase step in MSH production. A targeted disruption of the nativemshCgene inM.tuberculosisErdman produced no viable clones possessing either a disruptedmshCgene or reduced levels of MSH. However, when a second copy of themshCgene was incorporated into the chromosome prior to the targeted disruption, multiple clones having the native gene disrupted and the second copy ofmshCintact were obtained. These clones produced normal levels of MSH. These results demonstrate that themshCgene and, more generally, the production of MSH are essential for the growth ofM. tuberculosisErdman under laboratory conditions.
Long-Term Inhibition of Rho-Kinase Suppresses Neointimal Formation After Stent Implantation in Porcine Coronary Arteries: Involvement of Multiple Mechanisms
Authors: Matsumoto Yasuharu , Uwatoku Toyokazu , Oi Keiji , Abe Kohtaro , Hattori Tsuyoshi , Morishige Kunio , Eto Yasuhiro , Fukumoto Yoshihiro , Nakamura Kei-ichiro , Shibata Yosaburo , Matsuda Takehisa , Takeshita Akira , Shimokawa Hiroaki 
Published: November 2003

Objective—We recently demonstrated that Rho-kinase, an effector of the small GTPase Rho, is substantially involved in the pathogenesis of arteriosclerosis. In this study, we examined whether Rho-kinase is also involved in in-stent restenosis and if so, what mechanism is involved.Methods and Results—Pigs underwent stent implantation in the left coronary artery with or without administration of fasudil (30 mg/kg per day orally), a specific Rho-kinase inhibitor, starting 2 days before the procedure for a duration of 4 weeks. On day 28, reductions in coronary diameter and neointimal formation associated with macrophage accumulation, collagen deposition, and transforming growth factor (TGF)-β1 expression were noted at the stent site, and all were significantly suppressed by fasudil. On day 7, fasudil significantly increased the frequency of TUNEL-positive apoptotic cells, while it tended to reduce that of bromodeoxyuridine-positive proliferating cells in the neointima. Western blot analysis on day 7 demonstrated that phosphorylations of the ezrin/radixin/moesin family (a marker of Rho-kinase activity in vivo) and protein expression of monocyte chemoattractant protein-1and bcl-2 were upregulated at the stent site and were significantly suppressed by fasudil.Conclusions—These results indicate that long-term inhibition of Rho-kinase suppresses in-stent neointimal formation by multiple mechanisms, including reduced vascular inflammation, enhanced apoptosis, and decreased collagen deposition.
Thymosin β4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expression
Authors: Al-Nedawi Khalid N. I. , Czyz Malgorzata , Bednarek Radoslaw , Szemraj Janusz , Swiatkowska Maria , Cierniewska-Cieslak Aleksandra , Wyczolkowska Janina , Cierniewski Czeslaw S. 
Published: November 2003

AbstractThymosin β4(Tβ4), a 4.9-kDa polypeptide primarily known as a main G-actin–sequestering peptide, is present in high concentrations in various cells and in the circulation. We have found that Tβ4 upregulates the expression of plasminogen activator inhibitor 1 (PAI-1) in endothelial cells measured both at the level of mRNA and protein synthesis. This effect seems to be cell specific and was not observed when other cells such as human fibroblasts, PC3, and U937 were tested. Tβ4 significantly activated the PAI-1 promoter in EA.hy 926 cells transiently transfected either with plasmid p800LUC containing PAI-1 promoter fragment (–800 to +71) or the PAI-1 promoter linked with green fluorescent protein. Tβ4 mediated up-regulation of PAI-1 involved activation of the mitogen-activated protein kinase cascade. Furthermore, Tβ4 enhanced c-Fos/c-Jun DNA-binding activity to the activator protein 1 (AP-1)–like element (–59 to –52). The specificity of this binding activity was demonstrated by competition electrophoretic mobility shift assay and after transfection of EA.hy 926 cells with the mutated PAI-1 promoter. Taken together, these data indicate that, in response to Tβ4 stimulation, AP-1 activity increases to enhance PAI-1 transcription through its unique AP-1–like element at –59 to –52 in the PAI-1 promoter.
Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity
Authors: Kopp Christoph W. , Hölzenbein Thomas , Steiner Sabine , Marculescu Rodrig , Bergmeister Helga , Seidinger Daniela , Mosberger Isabella , Kaun Christoph , Cejna Manfred , Horvat Reinhard , Wojta Johann , Maurer Gerald , Binder Bernd R. , Breuss Johannes M. , Ecker Rupert C. , de Martin Rainer , Minar Erich 
Published: November 2003

AbstractActivation of inflammatory and procoagulant mechanisms is thought to contribute significantly to the initiation of restenosis, a common complication after balloon angioplasty of obstructed arteries. During this process, expression of tissue factor (TF) represents one of the major physiologic triggers of coagulation that results in thrombus formation and the generation of additional signals leading to vascular smooth muscle cell (VSMC) proliferation and migration. In this study, we have investigated the mechanisms by which inhibition of coagulation at an early stage through overexpression of tissue factor pathway inhibitor (TFPI), an endogenous inhibitor of TF, might reduce restenosis. In a rabbit femoral artery model, percutaneous delivery of TFPI using a recombinant adenoviral vector resulted in a significant reduction of the intimamedia ratio 21 days after injury. Investigating several markers of inflammation and coagulation, we found reduced neointimal expression of monocyte chemoattractant protein-1 (MCP-1), lesional monocyte infiltration, and expression of vascular TF, matrix metalloproteinase-2 (MMP-2), and MMP-9. Moreover, overexpression of TFPI suppressed the autocrine release of platelet-derived growth factor BB (PDGF-BB), MCP-1, and MMP-2 in response to factors VIIa and Xa from VSMCs in vitro and inhibited monocyte TF activity. These results suggest that TFPI exerts its action in vivo through not only thrombotic, but also nonthrombotic mechanisms.
A signaling mechanism for growth-related expression of fetal hemoglobin
Authors: Bhanu Natarajan V. , Trice Tiffany A. , Lee Y. Terry , Miller Jeffery L. 
Published: November 2003

Abstract
Increases in fetal hemoglobin have been identified after birth in several clinical settings associated with stressed or malignant erythropoiesis. To better understand the relationship between the expression of this fetal protein and growth, donated human erythroid progenitor cells were cultured in the presence of erythropoietin (EPO) plus the growth-modifying cytokine stem cell factor (SCF), and several growth-related signaling pathways were interrogated. Only the MEK1/2 inhibitor (PD98059) demonstrated significant effects on fetal hemoglobin. In the absence of PD98059, levels of fetal hemoglobin averaged 27.4% ± 7.9% in EPO+SCF compared with 1.26% ± 1.7% in EPO alone (P = .02). A linear dose response in levels of fetal hemoglobin to PD98059 was detected (0.16 μM = 27.13%, 0.8 μM = 19.6%, 4 μM = 12.2%, 20 μM = 1.54%). Western blot analyses revealed that SCF was required for phosphorylation of MEK and p44MAPK in this setting, and quantitative polymerase chain reaction demonstrated a significant increase in γ-globin mRNA. Particular perturbations of growth-related signaling may also function to activate tissue-specific genes normally expressed during fetal development. This concept may be relevant for the development of new treatment rationales for beta hemoglobinopathies.
Syndecan-2 is essential for angiogenic sprouting during zebrafish development
Authors: Chen Eleanor , Hermanson Spencer , Ekker Stephen C. 
Published: November 2003

AbstractWe used a morpholino-based gene-targeting screen to identify a novel protein essential for vascular development using the zebrafish, Danio rerio. We show that syndecan-2, a cell-surface heparan sulfate proteoglycan, is essential for angiogenic sprouting during embryogenesis. The vascular function of syndecan-2 is likely conserved, as zebrafish and mouse syndecan-2 show similar expression patterns around major trunk vessels, and human syndecan-2 can restore angiogenic sprouting in syndecan-2 morphants. In contrast, forced expression of a truncated form of syndecan-2 results in embryos with defects in angiogenesis, indicating that the highly conserved cytoplasmic tail is important for the vascular function of syndecan-2. We further show that vascular endothelial growth factor (VEGF) and syndecan-2 genetically interact in vivo using both gain-of-function and loss-of-function studies in zebrafish. VEGF-mediated ectopic signaling is compromised in syndecan-2 morphants, and ectopic syndecan-2 potentiates ectopic VEGF signaling. Syndecan-2 as a novel angiogenic factor is a potential candidate for use in the development of angiogenesis-based therapies.
Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant
Authors: Wan Tao , Zhou Xiangyang , Chen Guoyou , An Huazhang , Chen Taoyong , Zhang Weiping , Liu Shuxun , Jiang Yingming , Yang Feng , Wu Yanfeng , Cao Xuetao 
Published: November 2003

AbstractHeat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cells (DCs), has potent adjuvant effects that polarize responses toward Th1. With a calculated molecular weight of 54.8 kDa, Hsp70L1 is smaller in size than Hsp70 but resembles it both structurally and functionally. Hsp70L1 shares common receptors on DCs with Hsp70 and can interact with DCs, promoting DC maturation and stimulating secretion of the proinflammatory cytokines interleukin 12p70 (IL-12p70), IL-1β, tumor necrosis factor-α (TNF-α), and the chemokines IP-10, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, and normal T cell expressed and secreted (RANTES). The induction of interferon-γ–inducible protein 10 (IP-10) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC IL-12p70, CC-chemokine, and CCR7 and CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin(OVA)257-264 induces an OVA257-264-specific Th1 response and cytotoxic T lymphocyte (CTL) that results in significant inhibition of E.G7-OVA tumor growth. The ability of Hsp70L1 to activate DCs indicates its potential as a novel adjuvant for use with peptide immunizations; the Hsp70L1 antigen peptide hybrid may serve as a more effective vaccine for the control of cancer and infectious diseases.