bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new approach for epicardial permanent pacemaker implantation in children: case report
Authors: Yuan Dou , Lin Ke , Xu Yuanning 
Published: January 2024

Abstract

Background
High-grade atrioventricular block is the primary reason for epicardial permanent pacemaker implantation during the perioperative period in patients with congenital heart disease. Due to the smaller diameter of venous vessels in children, epicardial permanent pacemaker implantation is usually a preferred choice, we report one pediatric patient who received epicardial permanent pacemaker implantation using a new approach.
Case presentation
We present the case of a 2-year-old girl who underwent the modified Konno procedure and Pulmonary valvuloplasty surgery and presented after surgery with a High-grade atrioventricular block. At over 20 days after the patient underwent a redo-sternotomy which epicardial permanent pacemaker implantation. Medtronic Model 4965 Capsure Epi ® steroid-eluting unipolar epicardial pacing lead was immobilized on the surface of the right ear. The Medtronic 3830 pacing lead was screwed obliquely and clockwise under direct view from the surface of the right ventricle to the endocardium near the interventricular septum. The patient’s recovery was uneventful.
Conclusion
A Medtronic 3830 pacing lead was screwed into the myocardium through the epicardium, which is a feasible approach for implanting the ventricular pacing electrode.
Colorectal Carcinoma metastasizing to Scrotum: A series of five cases with unusual presentation and late recurrences from a single tertiary oncology centre of India
Authors: Bilala Disha , Yadav Subhash , Ankathi Suman Kumar , Kaushal Rajiv , Deshpande Gauri , Bal Munita , Deodhar Kedar , Menon Santosh , Ramadwar Mukta 
Published: January 2024

Abstract
Background
Colorectal carcinoma (CRC) is a common malignancy, frequently metastasizing to the liver, lungs, and regional lymph nodes. However, metastasis to the scrotum is exceedingly rare, with few cases reported in the literature. In this study, we present a series of five cases of colorectal carcinoma metastasizing to the scrotum, emphasizing their unusual clinical presentation and late recurrences.
Methods
We did a retrospective review of 7 years from 2015–2022 for cases of scrotal metastasis in cases of CRC.
Results
The means age in our study was 38 years (22–61 years) and the median time interval between the primary diagnosis and scrotal metastasis was 31.6 months (0-104 months). Case presentations included scrotal swelling initially misdiagnosed as a hydrocele (case 1), non-healing cutaneous ulcers (cases 3 and 5), a scrotal skin papilloma (case 4), and a cutaneous nodule (case 2).
Conclusion
This series of five cases highlights the rarity and diagnostic challenges associated with colorectal carcinoma metastasizing to the scrotum. The extended latency between primary tumor diagnosis and scrotal metastasis, coupled with atypical clinical presentations, underscores the importance of maintaining a high index of suspicion. Clinicians should be vigilant, especially when evaluating patients with a history of colorectal carcinoma, to promptly identify such uncommon metastatic sites.
The analysis of transcriptomic signature of TNBC – searching for the potential RNA-based predictive biomarkers to determine the chemotherapy sensitivity
Authors: Supplitt Stanislaw , Karpinski Pawel , Sasiadek Maria , Laczmanski Lukasz , Kujawa Dorota , Matkowski Rafal , Kasprzak Piotr , Abrahamowska Mariola , Maciejczyk Adam , Iwaneczko Ewelina , Laczmanska Izabela 
Published: January 2024

Abstract

Background
Neoadjuvant chemotherapy is the foundation treatment for triple-negative breast cancer (TNBC) and frequently results in pathological complete response (pCR). However, there are large differences in clinical response and survival after neoadjuvant chemotherapy of TNBC patients. The aim was to identify genes which expression significantly associates with the efficacy of neoadjuvant chemotherapy in patients with TNBC.
Methods
Transcriptomes of 46 Formalin-Fixed Paraffin-Embedded (FFPE) tumor samples from TNBC patients were analyzed by RNA-seq by comparing 26 TNBCs with pCR versus 20 TNBCs with pathological partial remission (pPR). Subsequently, we narrowed down the list of genes to those that strongly correlated with drug sensitivity of 63 breast cancer cell lines based on Dependency Map Consortium data re-analysis. Furthermore, the list of genes was limited to those presenting specific expression in breast tumor cells as revealed in three large published single cell RNA-seq breast cancer datasets. Finally, we analyzed which of selected genes were significantly associated with overall survival (OS) in TNBC TCGA dataset.
Results
A total of 105 genes were significantly differentially expressed in comparison between pPR versus pCR. As revealed by PLSR analysis in breast cancer cell lines out of 105 deregulated genes 42 were associated with sensitivity to docetaxel, doxorubicin, paclitaxel and/or cyclophosphamide. We found that 24 out of 42 sensitivity-associated genes displayed intermediate or strong expression in breast malignant cells using single cell RNAseq re-analysis. Finally, 10 out of 24 genes were significantly associated with overall survival in TNBC TCGA dataset.
Conclusion
Our RNA-seq based findings suggest that there might be transcriptomic signature consisted of 24 genes specifically expressed in tumor malignant cells for predicting neoadjuvant response in FFPE samples from TNBC patients prior to treatment initiation. Additionally, 9 out of 24 genes were potential survival predictors in TNBC. This group of 24 genes should be further investigated for its potential to be translated into a predictive test(s).
Artificial tiger bone powder Inhibits the Progression of Knee Osteoarthritis via the Wnt/β-catenin Pathway
Authors: Wu Yichao , Zhang Tiantian , Jia Qifei , Sui Cong 
Published: January 2024

Abstract
Knee osteoarthritis (KOA) is a common bone and joint disease around the world. This study tested the ability of Artificial tiger bone powder (ATBP) to inhibit the progression of KOA through the Wnt/β-catenin pathway. Forty Sprague–Dawley (SD) rats were randomly divided into a control group, a KOA group, a low-dose ATBP group and a high-dose group. Knee joints were injected with adjuvant to establish a rat model of KOA. Detect the changes in relevant indicators of rats in each group. interleukin (IL)-1β induced primary chondrocytes to establish the KOA cell model. After treatment with an agonist or inhibitor of Wnt/β-catenin, the levels of Wnt1, β-catenin were analyzed by PCR. Compared with the KOA group, knee joint swelling of the rats in the ATBP treatment groups was reduced, while the joint score were all significantly lower (P < 0.05). In the IL-1β-induced chondrocytes treated with ATBP, the expression of type II collagen (Col II) was increased significantly (P < 0.05). Compared with the IL-1β group, the levels of Wnt1, β-catenin in the agonist-induced group were significantly increased, while in the inhibitor-treated group they were significantly decreased (P < 0.05). ATBP inhibits the progression of KOA via the Wnt/β-catenin pathway.
Achieving NPVR ≥ 80% as Technical Success of High-Intensity Focused Ultrasound Ablation for Uterine Fibroids: a cohort study
Authors: Li Shuang , Yang Meijie , Yu Jingwen , Ma Wangwa , Deng Yongbin , Hu Liang , Chen Jinyun 
Published: January 2024

Abstract
Objective: To report the long-term re-intervention of patients with uterine fibroids after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation, and analyse the influencing factors of re-intervention in group of NPVR ≥80%.
Materials and Methods: The patients were divided into four groups according to different non-perfusion volume ratio (NPVR). Kaplan-Meier survival curve was used to analyse the long-term re-intervention in different NPVR groups, and Cox regression was used to analyse the influencing factors of re-intervention in the NPVR ≥ 80% group.
Main Results: Patients with single uterine fibroid who underwent USgHIFU from January 2012 to December 2019 in our hospital were enrolled. A total of 1,257 patients were enrolled, of which 920 were successfully followed up. The median follow-up time was 88 months, and the median NPVR was 85.2%. The cumulative re-intervention rates of 1, 3, 5, 8 and 10 years after USgHIFU were 3.4%, 11.8%, 16.8%, 22.6% and 24.1%, respectively. The 10-year cumulative re-intervention rate was 37.3% in the group of NPVR <70%, 31.0% in the group of NPVR 70%–79%, 18.2% in the group of NPVR 80%–89% and 17.8% in the group of NPVR ≥90% (P <0.05). However, no difference was found between the group of NPVR 80%−89% and the group of NPVR ≥90% (P=0.499). Age of patients and signal intensity on T2WI of tumours were independent risk factors for long-term re-intervention when NPVR was ≥80%. Lower age and higher signal intensity on T2WI corresponded to a higher risk of re-intervention occurrence.
Conclusion: USgHIFU, as an alternative treatment of uterine fibroids, has a reliable long-term efficiency. NPVR ≥80% can reduce the long-term re-intervention rates of patients, which can be used as a sign of technical success. However, an important step is to assess before ablation, considering both age of patients and fibroids of signal intensity on T2WI.
Trial registration: This retrospective study was approved by the ethics committee at our institution (Registration No. HF2023001; Date: 06/04/2023). The Chinese Clinical Trial Registry provided full approval for the study protocol (Registration No. CHiCTR2300074797; Date: 16/08/2023).
Parameters that can be used as predictors of mortality in the surgical intensive care unit among non-cardiac surgery patients receiving transfusion
Authors: Sadri Sevil , Sahin Bora , Tunay Burcu 
Published: January 2024

Abstract

Objective Postoperative complications significantly increase the mortality rate and thus follow-up of high-risk patients in the intensive care unit after surgery may reduce mortality. Methods This is a retrospective analysis and did not require informed consent due to its anonymous nature. Hospital records were screened to identify all adult patients (> 18 years) admitted to the inpatient surgical intensive care unit between January 2021 and March 2022. The records of patients who underwent non-cardiac surgery and were followed up in the postoperative intensive care unit between January 2021 and March 2022 were reviewed. Demographic characteristics, hematologic parameters and the number of transfusions performed in the intensive care unit were recorded and analyzed for their effect on postoperative. Results Length of stay in the ICU, need for and duration of mechanical ventilation, hemoglobin level, platelet count and ASA scores were found to have a statistically significant association with mortality (p < 0.05). Mean length of stay in the ICU was higher among patients who died (15.18 ± 20.82 days) compared to survivors. Similarly, mean duration of ventilation was higher among patients who died (14.52 ± 20.17 days) compared to survivors (p < 0.05). Univarity LR analysis showed that mechanical ventilation, ASA scores, hemoglobin level and platelet count were statistically significant predictors of mortality (p < 0.05). Conclusion Anemia is an independent risk factor for poor outcomes. Red blood cell transfusion is associated with a poor prognosis, but this association was not observed in patients with moderate-to-severe anemia. The findings suggest that platelet transfusion is a significant risk factor for mortality. Careful preoperative planning and multidisciplinary management efforts are needed to reduce the use of postoperative transfusions.
Causal relationship between rheumatoid arthritis and bronchiectasis: A bidirectional Mendelian randomization study
Authors: Chen Zehu , Li Xuegang , Shi Honglei , Huang Yiying , Liu Jing 
Published: January 2024

Abstract
Background
Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this potential causal linkage, we conducted a two-sample Mendelian randomization (MR) analysis to explore the bidirectional causality between RA and bronchiectasis.
Methods
Summary statistics for RA and bronchiectasis were obtained from the IEU OpenGWAS database We employed various methods, including inverse variance weighting (IVW), MR-Egger, weighted median, weighted mode, and simple mode, to explore potential causal links between RA and bronchiectasis. Additionally, a series of sensitivity studies, such as Cochran's Q test, MR Egger intercept test, and leave-one-out analysis, were conducted to assess the MR analysis's accuracy further.
Results
In the forward MR analysis, the primary analysis indicated that a genetic predisposition to RA correlated with an increased risk of bronchiectasis in European populations (IVW odds ratio (OR): 1.28, 95% confidence interval (CI): 1.20–1.37, p = 1.18E-13). Comparable results were noted in the East Asian subjects (IVW OR: 1.55, 95% CI: 1.30–1.34, p = 8.33E-07). The OR estimates from the other four methods were consistent with those obtained from the IVW method. Sensitivity analysis detected no evidence of horizontal pleiotropy or heterogeneity. Conversely, in the reverse MR analysis, we found no evidence to support a genetic causality between bronchiectasis and RA in either European or East Asian populations.
Conclusion
This study indicates that genetic predisposition to RA correlates with a heightened risk of bronchiectasis in both European and East Asian populations. These results imply that routine screening for bronchiectasis in RA patients could be beneficial, and effective management of RA may contribute to a reduced risk of bronchiectasis. Future research should aim to clarify the underlying mechanisms linking these two conditions.
Objective sleep quality predicts subjective sleep ratings: a multiday observational study
Authors: Pierson-Bartel Róbert , Ujma Péter Przemyslaw 
Published: January 2024

Abstract
In both clinical and observational studies, sleep quality is usually assessed by subjective self-report. The literature is mixed about how accurately these self-reports track objectively (e.g. via polysomnography) assessed sleep quality, with frequent reports of a very low or no association. However, previous research on this question focused on between-subject designs, which may be confounded by trait-level variables. In the current study, we used the novel Budapest Sleep, Experiences and Traits Study (BSETS) dataset to investigate if within-subject differences in subjectively reported sleep quality are related to sleep macrostructure and quantitative EEG variables assessed using a mobile EEG headband. We found clear evidence that within-subject variations in sleep onset latency, wake after sleep onset, total sleep time, and sleep efficiency affect self-reported sleep quality in the morning. These effects were replicated if detailed sleep composition metrics (percentage and latency of specific vigilance states) or two alternative measures of subjective sleep quality are used instead. We found no effect of the number of awakenings or relative EEG delta and sigma power. Between-subject effects (relationships between individual mean values of sleep metrics and subjective sleep quality) were also found, highlighting that analyses focusing only on these may be erroneous. Our findings show that while previous investigations of this issue may have been confounded by between-subject effects, objective sleep quality is indeed reflected in subjective sleep ratings.
Factors associated with severe cognitive decline in community-dwelling older persons in Cameroon (Sub-Saharan African)
Authors: Simo-Tabue Nadine , Magnerou Mélanie Annick , Mounsamy Ludwig , Metamno Salvatore , Letchimy Laurys , Dartigues Jean-François , Kuate-Tegueu Callixte , Tabué-Teguo Maturin 
Published: January 2024

Abstract

Severe cognitive decline (SVD) is a major cause of dependency in older people. The aim of this study was to identify factors associated with severe cognitive decline, as assessed by the mini-mental state examination (MMSE), in community-dwelling adults aged 55 + in Cameroon. Method: Data are from a cross-sectional survey carried out in Cameroon. The Cognitive status was assessed using the MMSE and a score of 18/30 or lower is considered as a proxy of severe cognitive decline Result: A total of 403 adults participated in the study. Of these, 16 (3.9%) had an MMSE score < 18 and were considered to have severe cognitive decline. The rate of severe cognitive decline increased with rising age, from 2.1% in those aged 55 to 64 years, to 3.3% in those aged 65 to 74, and 11% in those aged 75 and older. The factors associated with severe cognitive decline (MMSE score < 18) by multivariate analysis in our population are level of education (OR 0.10 (95%CI 0.02–0.37), p < 0.01), body mass index (OR 0.88 (95%CI 0.78–0.99), p = 0.03). and IADL score (OR 0.12 (95%CI 0.03–0.38), p < 0.001). Conclusion: The three main factors associated with cognitive decline were education, IADL dependency and BMI. This study shows that among older people in sub-Saharan Africa, the effect of BMI, IADL dependency and education on cognitive function appears similar to that observed in middle- and high-income countries.
Characteristics of deformation and damage of surrounding rock along the top roadway in the working face of an isolated island and its evolution law
Authors: Yun Qing-Long , Wang Xiao-He , Jing Wu , Zhang Wen-Bo , Wei Xiao-Xiang , Wang Jiang-Hao 
Published: January 2024

Abstract
In order to study characteristics of deformation and damage of surrounding rock along the top roadway in the working face of an isolated island and its evolution law, this paper takes a mine in Yangquan City, Shanxi Province, China, as the engineering background, and adopts FLAC 3D numerical simulation and on-site measurements to conclude that at different locations of the 15106 island face along the top of the roadway peripheral rock over the front face, the roadway in the excavation period and the mining phase all experience the asymmetric expansion of the plastic zone and gradually penetrate the plastic zone of the coal pillar, and overall experience the stage of the roadway sub-gang not penetrated and destroyed, the stage of the roadway sub-gang penetrated and destroyed, the stage of the development of the plastic zone of both gangs after penetrated and destroyed. In general, the roadway has experienced the stage of the sub-gang not penetrating and destroying, the stage of the roadway penetrating and destroying, and the stage of the roadway two-gang plastic zone development after penetrating and destroying. The asymmetric destruction of the roadway has the characteristics of rock selectivity and leaping through, and the rock layer of the roadway roof is relatively hard, and no large-scale destruction occurs; Through drilling and snooping, it was concluded that the large range of positive gang damage, the development of fissures, and the large depth of the roadway gang damage were the direct causes of the gang bulge, and that the size of the plastic zones of the two gangs of the roadway was positively correlated with the relative distance. During the monitoring period, the roadway displacement continued to increase, which is consistent with the situation in the coal mine.
Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single- center retrospective Australian study
Authors: Kornfeld Belen , Taha Ahmed , Kyang Lee , Sim Hao-wen , Dewhurst Suzannah , McCloy Rachael , Chin Vanessa , Earls Peter , Parker Andrew , Leavers Brett , Forstner Dion , Floros Peter , Crawford Julia , Gallagher Richard 
Published: January 2024

Abstract
Background
We present a cohort review of TORS resection for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and its associated oncological outcomes spanning a 10-year period.
Methods
A retrospective case series review was performed of patients undergoing primary surgical treatment for HPV-associated OPSCC through the St. Vincent’s Head and Neck Cancer service from 2011–2022. The primary outcomes were to investigate complete resection of the primary tumour, rates of recurrence, and survival analysis. Secondary outcomes included complications, rates of adjuvant therapy, sites of recurrence and rates of percutaneous endoscopic gastrostomy (PEG).
Results
184 patients underwent TORS-based therapy with neck dissection, and guideline directed adjuvant therapy for HPV-associated OPSCC. Our median follow up was 46 months. The positive margin rate on final histopathology analysis was 10.9%. Adjuvant therapy was indicated in 85 patients (46%). The local recurrence rate was 10.9% with the majority (80%) of patients recurring in the first 3 years since treatment. The disease-specific survival at 3 years was 98.6% and at 5 years was 94.4%. The 3-year and 5-year OS for the cohort was 96.7% and 92.5% respectively. Presence of extranodal extension and positive margins were associated with increased risk of recurrence, whereas adjuvant therapy was found to be a protective factor for both overall recurrence and survival. Major complications occurred in 12 patients (6.5%), resulting in one death.
Conclusion
This study has demonstrated that primary surgical therapy for HPV-associated OPSCC is a safe and effective treatment modality with low local recurrence and complication rates, and overall survival benefits.
Application of Indocyanine Green-Labeled Fluorescence Laparoscopy in Inguinal Hernias (Nyhus Types III and IV)
Authors: Zhang Qi , XU Xiujuan , Ma Jun , Ling Xinjian , Wang Yongsheng , Zhang Yaming 
Published: January 2024

Abstract
Background: Laparoscopic inguinal hernia (IH) repair presents escalated risks of surgical complications, notably bleeding, particularly in Nyhus types III and IV IHs. In this study, we introduced an innovative technique using indocyanine green-labeled fluorescence laparoscopy to mitigate intraoperative complications, including bleeding and rupture of the hernial sac.
Methods: This retrospective study reviewed records of 17 patients who underwent laparoscopic IH repair at Anqing Municipal Hospital between July and August 2023. Intraoperatively, fluorescence imaging was utilized to trace the pathway of the spermatic vessels and outline the boundaries of the hernia sac to facilitate a thorough dissection.
Results: The procedure was successfully completed in all 17 patients, with a median operation time of 42 min (range: 30–51 min). Median intraoperative blood loss was 5 ml (range: 3–8 ml). Complete dissection of the hernia sac was achieved in each case without any incidents of sac rupture. Hemodynamic parameters of blood flow within the spermatic artery on postoperative day 1 showed no statistically significant deviations from the preoperative values. Furthermore, during the 2-month follow-up period, there were no cases of seroma formation or hernia recurrence.
Conclusion: Employing indocyanine green-labeled fluorescence laparoscopy in Nyhus types III and IV IH repairs significantly reduces intraoperative complications, notably bleeding and rupture of the hernial sac. This technique demonstrated a negligible impact on the hemodynamic parameters of the spermatic artery and reduced the overall surgical time.