bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-dimensional multi-objective evolutionary algorithm based on adaptive penalty parameters and improved association methods
Authors: Wang Shanshan , Wang Jiacheng , Xiang Siying , Zeng Liang 
Published: January 2024

Abstract

The balance between convergence and diversity is a crucial and challenging aspect of evolutionary multi-objective optimization. In order to balance them, this paper proposes a high-dimensional multi-objective evolutionary algorithm based on adaptive penalty parameters and an improved association method (MOEAAP). An adaptive penalty parameter is first proposed and utilized in non-dominated sorting based on reference points, allowing for the dynamic assignment of Pareto ranks to the population according to changes in iteration counts and objective dimensions. Additionally, an improved association method is employed to categorize candidate solutions into associated and non-associated solutions, while associated solutions are given preferential consideration. To verify the feasibility of the proposed algorithm, it is compared with several mainstream algorithms through simulation experiments, and is applied to multiple practical applications. Experimental results show the algorithm effectively balances convergence and diversity in high-dimensional, complex multi-objective optimization.
Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE inspired by Bryophyllum pinnatum: A Structural Exploration
Authors: Olugbogi Ezekiel A. , Omirin Emmanuel S. , Omoseeye Shola D. , Adebisi Aanuoluwapo D. , Owolabi Blessing T. , Aderiye Michael A. , Ajayi Oluwanifemi M. , Onekhena Victor O. , Olatunji Daniel A. , Adetunji Racheal A. , Makanjuola Odunayo B. , Ajibare Ayodeji J. , Folawiyo Moshood , Akintoye Olubode O. , Omotuyi Olaposi I. 
Published: January 2024

Abstract
Alzheimer's disease (AD)and Parkinson's disease (PD) are progressive neurodegenerative disorders with overlapping symptoms. Reduced acetylcholine levels in AD are addressed using Acetylcholinesterase (AChE) inhibitors. Monoamine oxidase B (MAO-B) inhibitors prevent dopamine breakdown in PD. Bryophyllum pinnatum, a medicinal plant, that has been used as traditional treatments for various disorders because of its phytochemicals. This study explores its ligands as potential medications for AD and PD by inhibition of AChE and MAO-B. Computer-aided drug design was conducted using Schrödinger Suite software and Maestro 12.8. Ligands from B. pinnatum and standard drugs were docked to the active sites of MAO-B and AChE. ADMET screening and MM/GBSA analysis were performed. Pharmacophore modeling was used to identify compounds matching the reference ligands. After application of all screenings, 4 and 6 hit compounds were found for MAO B & AChE respectively based on good docking score and MM/GBSA as well as good ADMET properties. Pinoresinol was found to be the most potent of the hit compounds. These compounds could be used as neuroprotective agent in near future. Hence, this study provides evidence for consideration of valuable ligands in Bryophyllum pinnatum as potential AChE and MAO-B inhibitors and further in vivo and in vitroinvestigation might prove their therapeutic potential.
Modeling of Ankle Joint Range of Motion and Landing Quality Scores in Female Soccer Players with Quantile Regression Approach
Authors: Rad Niloofar Fakhraei , Alimoradi Mohammad , Antohe Bogdan , Uysal Hüseyin Şahin , Korkmaz Sezgin , Mohammadian Zahra 
Published: January 2024

Abstract

Purpose
This study aimed to model the relationship between ankle dorsiflexion range of motion and landing quality during the Soccer-Specific Jump-Landing task (SSJL) on the non-dominant extremity in elite and amateur female soccer players using a quantile regression approach.
Methods
Fifty-five amateur and forty-seven professional female soccer players participated in the study. The relationship between ankle dorsiflexion range of motion (DF-ROM) and soccer-specific jump-landing landing technique quality was evaluated using Pearson's product-moment correlation analysis and linear regression analysis
Results
There was a statistically significant correlation between DF-ROM and SSJL landing quality in amateur female soccer players (r = − 0.63, p = 0.001), no significant correlation was found in elite female soccer players (r = 0.22, p = 0.13). QR model results for amateur female soccer players showed that ankle DF-ROM level affects landing quality more in the group with high SSJL landing quality scores (e.g., Q75 and Q90) compared to the group with low SSJL landing quality scores (e.g., Q10 and Q25).
Conclusions
Ankle DF-ROM level may be a functional clinical measurement for amateur female athletes in determining landing-related injury risk factors during SSJL.
Fuzzy Numbers Unraveling the Intricacies of Neural Network Functionality
Authors: Ramaj Vehbi , Elezaj Rame , Čajić Elvir 
Published: January 2024

Abstract
This research delves into the synergy between fuzzy numbers and neural networks, presenting a novel perspective on interpreting neural network functionality. Fuzzy numbers offer a flexible framework to capture uncertainties and imprecisions, enriching the interpretability of neural network outputs. By integrating fuzzy number theory into the analysis, our study seeks to enhance the transparency and reliability of neural network models, contributing to a more nuanced understanding of their inner
Early laparoscopic cholecystectomy in acute mild gallstone pancreatitis. Is there a role for routine admission contrast-enhanced CT Scan?
Authors: Küstner Stefan , Gallardo Martin , Higuera Felipe , Claria Rodrigo Sánchez , Mazza Oscar , Ardiles Victoria , Pekolj Juan , De Santibañes Martín 
Published: January 2024

Abstract

Purpose: This study aims to evaluate the efficacy of admission contrast-enhanced CT scans in formulating strategies for performing early laparoscopic cholecystectomy in cases of acute gallstone pancreatitis.
Methods: Patients diagnosed with acute gallstone pancreatitis underwent a CT scan upon admission (after at least 24 hours from symptom onset) to confirm diagnosis and assess peripancreatic fluid, collections, gallstones, and common bile duct stones. Patients with mild acute gallstone pancreatitis, following the Atlanta classification and Baltazar score A or B, were identified as candidates for early cholecystectomy (within 72 hours of admission).
Results: Within the analyzed period, 272 patients were diagnosed with mild acute gallstone pancreatitis according to the Atlanta Guidelines. A total of 33 patients (12.1%) were excluded: 17 (6.25%) due to SIRS, 10 (3.6%) due to local complications identified in CT (Balthazar D/E), and 6 (2.2%) due to severe comorbidities. Enhanced CT scans accurately detected gallstones, common bile duct stones, pancreatic enlargement, inflammation, pancreatic collections, and peripancreatic fluid. Among the cohort, 239 patients were selected for early laparoscopic cholecystectomy. Routine intraoperative cholangiogram was conducted in all cases, and where choledocholithiasis was present, successful treatment occurred through common bile duct exploration. Only one case required conversion from laparoscopic to open surgery. There were no observed severe complications or mortality.
Conclusion: Admission CT scans are instrumental in identifying clinically stable patients with local tomographic complications that contraindicate early surgery. Patients meeting the criteria for mild acute gallstone pancreatitis, as per Atlanta guidelines, without SIRS or local complications (Baltazar D/E), can safely undergo early cholecystectomy within the initial 72 hours of admission.
Effect of oxygen-containing chemical fuel additives on energy, emission and engine combustion parameters for reducing carbon footprint
Authors: ÖZER Salih 
Published: January 2024

Abstract
There have been many research and development studies on the use of biodiesel fuels in compression ignition engines. In recent years, studies with ternary fuel blends formed with different additives to improve the performance characteristics of diesel/biodiesel fuel blends have gained importance. In this study, D80B20, D50B50, D30B50S20, and D30B50G20 fuel blends were formed by mixing biodiesel obtained from canola oil with pure diesel, solketal and butyl diglycol at different ratios. These fuel blends were tested in a compression ignition direct injection diesel engine at a constant engine speed of 3000 rpm and different engine load conditions and their engine performance, exhaust emission and combustion characteristics were investigated. In addition, the thermal and exergy efficiencies of these fuels were calculated as a result of thermodynamic analyses using the results obtained in experimental studies. Improvements in combustion performance (in-cylinder pressure, heat release rate, rate of pressure rise and cumulative heat release) and exhaust emissions (CO, HC and smoke) were observed with the addition of solketal and butyl diglycol to diesel-biodiesel binary fuel blends. Exhaust gas temperatures increased with the addition of solketal and butyl diglycol to the binary fuel blends. In the thermodynamic analysis, the lowest exergy destruction and total exergy losses were calculated for D30B50S20 fuel. Therefore, the highest thermal efficiency and exergy efficiency were realised in D30B50S20 fuel.
Comparative analysis of the use of original and standard methods of rehabilitation treatment of dorsopathy
Authors: Yakovlev E. V. , Zhivolupov S. A. , Gnevyshev E. N. , Vetrova T. V. , Butko D. Yu. , Davydov А. T. , Tasoev G. S. , Danilenko L. A. , Kalinina M. V. 
Published: January 2024

Introduction. The increase in the number of requests for medical help for pain in dorsopathy determines the relevance of this problem. Among all the conditions included in the Health Expenditure Survey, non-specific musculoskeletal back pain ranks first in the world. A special place belongs to cervicothoracic dorsopathy (CТD), which are the most common in developed countries and are characterized by a variety of clinical forms. There is a need to develop safe and effective complexes for the medical rehabilitation of patients with СТD. The complex method of СТD treating with the obligatory use of drug and non-drug methods of treatment prescribed together or sequentially in one complex, in our opinion, is the most optimal.Aim. To conduct a comparative evaluation of the therapeutic efficacy of restorative treatment methods in patients with cervicothoracic dorsopathy.Materials and methods. Patients with cervicothoracic dorsopathy (n = 220), stratified into 2 comparable groups, were studied, to whom the original (n = 155) and standard (n = 65) methods of restorative treatment were applied. The original method of treatment assumed a combined therapeutic effect with the use of drug therapy and a rehabilitation complex of physiotherapeutic and psychotherapeutic sessions. Statistical analysis included a comparative assessment of the intensity of the pain syndrome, static-dynamic and reflex disorders before and after the therapy.Results. The original and standard methods used in the course of the study statistically significantly (p < 0.05) reduced the intensity of the pain syndrome and reduced the frequency of reflex disorders. At the same time, the use of the original method of therapy was more effective (p < 0.05) in reducing the severity of the pain syndrome and reducing the frequency of reflex disorders in subgroups of patients, both with uncomplicated and complicated forms of cervicothoracic dorsopathy. The use of a standard method of therapeutic effect significantly reduced the frequency of manifestation of static-dynamic disorders in the group with uncomplicated forms of dorsopathy, while in patients with complicated forms of cervicothoracic dorsopathy, no therapeutic effect was achieved.Conclusions. The original method of therapy has confirmed its effectiveness, which indicates the need and justification for the use of combined restorative treatment of patients with cervicothoracic dorsopathy.
Experience of pyridoxin and glutamic acid use in effective correction of the main asthenia manifestations
Authors: Shishkova V. N. , Shishkov V. A. , Kapustina L. A. , Mashkovtseva E. V. , Nartsissov Ya. R. 
Published: January 2024

Introduction. Asthenia manifestation treatment is an urgent problem due to its high frequency in outpatients.Аim. To evaluate in a controlled randomized clinical trial the efficacy and tolerability of the course use of a combination of pyridoxine and glutamic acid in patients with asthenic complaints.Materials and methods. 50 outpatients with main asthenia manifestations were included in the study if they complied inclusion criteria and signed the informed consent. After randomization, in group 1 a combined supplement with 2.5 mg of pyridoxin and 100 mg of glutamic acid (Metabovit® Life Energy, MNPK “BIOTIKI”) was added to therapy 1 tablet a day sublingually, in group 2 patients received basic therapy for chronic diseases only. The duration of observation was 21 days. Before and after the end of the study all patients underwent neuropsychological examination, which included the questionnaires: Multidimensional Fatigue Inventory (MFI-20), a Reader stress test (adopted by O.Kopina), a questionnaire on the level of life exhaustion (The Maastricht Questionnaire), a “Schulte tables” test with working efficiency evaluation.Results. In the group of patients receiving Metabovit® Life Energy 1 tablet a day, in comparison with the control group (p < 0.001) the overall score on the MFI-20 self-questionnaire decreased and amounted to 29 [26; 30]; Δ MFI-20 was equal to -22 [-27; -16]; the results reached normative values for most participants; improved time the performance of the “Schulte tables” test decreased by more than 9 seconds; stress levels decreased by almost 30% in men and 20% in women; the indicator of life exhaustion decreased by 60%. In patients in the control group, no significant changes in the studied indicators were detected by the end of the follow-up.Conclusion. In the group of patients who received the biologically active food supplement Metabovit® Life Energy, there was a significant positive dynamics and regression of most of the symptoms of asthenia, in comparison with the control group.
Experimental study of the interstitial effect of a semiconductor laser with a wavelength of 445 nm on a biological model
Authors: Ivanov N. I. , Zakharova G. P. , Shabalin V. V. , Gaidukov S. S. 
Published: January 2024

Introduction. This study presents the results of interstitial exposure of a semiconductor laser with a wavelength of 445 nm to biological tissue samples at different pulsed wave power in a constant mode, with a contact method.Aim. To study the interstitial effect of a semiconductor laser with a wavelength of 445 nm on experimental tissue samples in a constant mode at different power.Materials and methods. As an experimental sample, we used biological tissue with a developed vascular structure in the form of pig liver. The source of laser radiation was a semiconductor laser with a wavelength of 445 nm, with a power range from 0.5 to 4 watts. When working with biological tissue samples, we evaluated their external and internal changes after laser exposure. The exposure time during interstitial exposure was 1 mm/sec with a 20 mm immersion depth of the laser fiber into the fabric. The results of the macro and microscopic picture were evaluated using histological examination and morphometry of the zones of destruction and coagulation necrosis, on a transverse section of the tissue.Results. The results of an experimental study indicate that interstitial laser exposure has a pronounced coagulation effect combined with a cutting effect. The optimal combination of coagulation and cutting effect of exposure, accompanied by visual contractility of the tissue, without excessive carbonation at a power of 3.0 watts.Conclusion. The use of interstitial exposure of a semiconductor laser with a wavelength of 445 nm on experimental tissue samples in a constant mode at different power showed the predominance of the coagulation effect in combination with the cutting effect with a pronounced reduction in tissue volume. Experiments have shown that the power of 3 W is the optimal power of laser exposure in the interstitial method, in which there is a pronounced reduction in the volume of the studied drug without excessive carbonation.
Double blind randomized placebo-controlled study of the efficacy and safety of proroxan in the complex therapy of generalized anxiety disorder
Authors: Goncharov O. V. , Bereza Zh. V. , Goncharova E. O. , Tikhomirov D. I. 
Published: January 2024

Introduction. The clinical picture of generalized anxiety disorder is characterized by diffuse anxiety, muscle tension and multiple symptoms of hyperactivity of the sympathetic part of the autonomic nervous system. As an alpha-adrenoblocker, proroxan can reduce the hyperactivity of the autonomic nervous system, thereby reducing the severity of anxiety and its somatic symptoms.Aim. To evaluate the efficacy of proroxan in the correction of autonomic disorders in patients with generalized anxiety disorder compared to placebo.Materials and methods. 100 people participated in the study: 50 – in the study group received the SSRI escitalopram, 50 – in the control group received SSRI + placebo. The diagnosis of generalized anxiety disorder was made on the basis of ICD-10 criteria. Psychometric assessment using the Montgomery-Asberg scale was performed (only at the screening visit). Weekly psychometric evaluation was performed using the Hamilton anxiety scale, the SCL-90-R scale to assess somatic manifestations of anxiety, and general clinical impression scales (CGI-S disease severity and CGI-I general improvement).Results. In the course of the study, statistically significant decrease in the mean value of CGI-S scale was observed in both groups, however, more pronounced in the proroxan group (p > 0.05); in the CGI-I scale, more pronounced improvement was observed in the first week of treatment in the proroxan group (p > 0.05). The HAM-A scale also showed a more significant reduction in anxiety in the proroxan group than in the placebo group (p > 0.05). The SCL-90-R SOM scale showed a decrease in the mean value in both groups, more pronounced in the proroxan group, which confirms the effect of the drug on autonomic symptoms of anxiety (p > 0.05).Conclusions. The obtained results confirm the superiority of combination therapy with escitalopram and proroxan in the treatment of generalized anxiety disorder compared to monotherapy. The advantages of proroxan were the absence of sedative effect and, in general, good tolerability, absence of withdrawal syndrome and control of vegetative manifestations of anxiety.
A drought study in the basin of Lake Urmia under climate change scenarios with higher spatial resolution to understand the resilience of the basin
Authors: Mohammad Pourian Bazzaz Pariya , Sadeghfam Sina , Khatibi Rahman , Nourani Vahid 
Published: January 2024

Abstract

The exposure of the basin of Lake Urmia to meteorological droughts under climate change scenarios is investigated in this study. Should the catastrophic disappearance of the lake be explained by climate change, the basin would not be resilient to droughts in the future. This is examined by a climate change modelling involving downscaling: use 11 general circulation models to provide climate variables downscaled to a high spatial resolution of 57 stations deriving a correlation between observed time series at the base period and climatic variables; projection: derive precipitation at near/far future using the equations; and drought studies: derive 1-month standard precipitation index at the base and near/far future periods. The results identify the following: (i) in the base period, the lowest and highest biases are −2.5 and 3.7 mm, respectively; (ii) in the near/far future periods, the zones are less prone to meteorological droughts in the south, where water is plentiful, but prone in its north, where water is relatively scarce; (iii) the areas are likely to get drier or wetter but their ratios are unlikely to change. This resilience underpins the urge to appropriate policymaking, decision-making, and planning systems to ensure that the basin is made incrementally more resilient.
Association of COVID with Mycosis in General
Authors: Kaur Gurpreet , Kaur Rajinder , Sumanpreet  , Kaur Manpreet 
Published: January 2024

Background:
The COVID-19 pandemic caused by SARS-CoV-2 is a respiratory disease
which created havoc worldwide, was accompanied by another peculiar, otherwise rare, secondary
fungal infection Mucormycosis which was observed at exceptionally high incidence in India during
the second wave of COVID-19. The article explores possible links between the two infectious diseases
to understand a higher-than-normal occurrence of Mucormycosis in COVID-19 patients. Coronavirus
enters the patients through ACE-2 and many other receptors like- NRP-1, TfR, CD-126, and
CD-26. Virus bind to cells possessing these receptors and affect their proper functioning, disturbing
homeostatic metabolism and resulting in conditions like hyperglycemia, Diabetic Ketoacidosis
(DKA), low serum pH, iron overload, anemia, hypoxia, and immunosuppression as explained in the
article. All these outcomes provide a very supportive environment for the attack and spread of Mucormycosis
fungi. The major receptor for Mucormycosis in humans is the GRP-78. Its expression is
upregulated by coronavirus entry and by hyperferritinemia, hyperglycemia, and acidic conditions
prevalent in COVID patients, thus providing an easy entry for the fungal species. Upregulation of
GRP-78 furthermore damages pancreatic β-cells and intensifies hyperglycemia, showing quite a
synergic relationship. Inordinate rise of Mucormycosis cases in India might be explained by facts
like- India possessing a large proportion of diabetic patients, emergence of a very deadly strain of
coronavirus- Delta strain, higher doses of steroids and antibodies used to treat patients against this
strain, overburdened health care services, sudden much higher need of oxygen supply and use of
industrial oxygen could explain the Mucormycosis outbreak observed in India during the second
wave of COVID-19.

Objective:
The present review discusses the functional interdependence between COVID-19 and
Mucormycosis and summarizes the possible synergic links between COVID and Mucormycosis.

Conclusion:
The receptors and metabolic pathways affected by COVID-19 result in severe physiological conditions- hyperglycemia, DKA, anemia, iron overload, immunosuppression, and hypoxia.
All these conditions not only increase the expression of GRP-78, the major receptor for entry of fungi but also play a crucial role in providing quality media for Mucormycosis fungus to establish and
grow. Hence explains the fungal epidemic observed in India during the second wave of COVID-19
in India.