bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating internal transmitter and external tag retention by Walleye in the Laurentian Great Lakes over multiple years
Authors: Colborne S. F. , Faust M. D. , Brenden T. O. , Hayden T. A. , Robinson J. M. , MacDougall T. M. , Cook H. A. , Isermann D. A. , Dembkowski D. J. , Haffley M. , Vandergoot C. S. 
Published: February 2024

Abstract

Objective
Both electronic tags (e.g., acoustic and radio transmitters) and conventional external tags are used to evaluate movement and population dynamics of fish. External tags are also sometimes used to facilitate the recovery of internal electronic tags or other instrumentation because healing can make it difficult to identify fish with internal tags based on appearance alone. With both tag types, tag shedding and failure of electronic tags can affect accuracy and precision of study results.

Methods
We used a decade (2011–2021) of recapture data for Walleye Sander vitreus tagged in the Laurentian Great Lakes, where fish were double- or triple-tagged with external tags (T-bar, loop, or internal anchor tags) and internal acoustic transmitters, to quantify external tag and internal transmitter shedding and transmitter failure rates.

Result
In total, 1125 (33%) Walleye were recovered that had retained at least one external tag or internal transmitter. No confirmed cases of transmitter shedding were observed; 15 of 899 transmitters (2%) that were checked for functionality failed prior to the expected battery expiration. The retention of external T-bar tags 1 year after release differed depending on whether the tag was placed anterior or posterior to the secondary dorsal fin (anterior, fish length = 420 mm: 73% retention; anterior, fish length = 700 mm: 73%, posterior: 63%) but was &lt;26% after 4 years for both tag positions and fish sizes. Internal anchor tags had an 88% 1-year retention probability and 81% 4-year retention probability. Loop tags had the highest 1-year retention (89%) but after 4 years retention (28–34% depending on agency) was comparable to that of T-bar tags.

Conclusion
Better understanding of tag retention characteristics through long-term tagging studies such as this can inform study design, be considered in model design, and ultimately improve inferences from mark–recapture studies.
Design and analysis of optimal AGC regulator for multi‐area power systems with TCPS and energy storage unit in deregulated environment
Authors: Mishra Ram Naresh , Kumar Narendra , Chaturvedi Devendra Kumar 
Published: February 2024

AbstractIn today's electric power network, fast changes are the norm, and auxiliary services such as automatic generation control (AGC) play a crucial role in maintaining the quality of the power supply. AGC ensures a balance between power generation, demand, and losses to sustain frequency stability and variation in tie‐line power within a set limit, even when the load changes. To accomplish this, it is always beneficial to consider new approaches to controlling the situation. This paper introduces the design of new AGC regulators that consider deviation in DC tie‐line power as an extra control variable for the turbine controller. In this study, three different deregulated power systems (containing two control areas), namely three thermal generations, the combination of one thermal and two hydro generations, and three hydro generations, including two power distribution companies (DISCOs) in each control area. These optimal AGC regulators are implemented in the proposed thermal–thermal–thermal system to carry out the various power contracts. The results have shown that the dynamic outcomes meet the AGC standards. To improve further dynamic results and the proposed systems' stability margins by incorporating redox flow batteries (RFB). In actual operating conditions, the system parameters do not remain constant due to the aging effect, assumptions made in simplifying the mathematical model, etc. Thus, ±50% deviations in the nominal value of system parameters to assess how well the optimal AGC regulators perform in the system under investigation. The suggested realistic AGC system incorporates many parameter fluctuations and works well with the optimal AGC regulators developed for the proposed plans. This study expanded to include a two‐area, thermal‐hydro‐hydro (THH) system under a deregulated framework connected via an asynchronous transmission link with or without a thyristor‐controlled phase shifter (TCPS) and RFB. The genetic algorithm (GA) can solve many issues and has global search, flexibility to varied problem types, intrinsic parallelism, and the ability to handle massive, complex search spaces. Thus, a two‐area deregulated hydro‐hydro‐hydro system with parallel tie‐lines utilizes GA‐PID, GA‐FOPID, and GA‐(1 + PI)‐FOPID controllers. Moreover, a random load disturbance (RLD) is employed in each section of the offered approach to show the resilience and elite performance of the proposed control strategy. To produce various dynamic reactions in the plans, MATLAB software version R2013a is employed.
Context matters when rewilding for climate change
Authors: Burak Mary K. , Ferraro Kristy M. , Orrick Kaggie D. , Sommer Nathalie R. , Ellis‐Soto Diego , Schmitz Oswald J. 
Published: February 2024

Abstract

There is a cross‐sectoral push among conservationists to simultaneously mitigate biodiversity loss and climate change, especially as the latter increasingly threatens the former. Growing evidence demonstrates that animals can have substantial impacts on carbon cycling. As such, there are increasing calls to use animal conservation and rewilding to dually overcome biodiversity loss and mitigate climate change.

Specifically, trophic rewilding—which involves restoring intact animal communities, functional roles and trophic structure within food webs, and natural ecosystem processes—utilizes a rewilding framework to simultaneously support biodiversity conservation and carbon capture and storage. Trophic rewilding is a complex conservation approach to mitigating climate change, involving accurate estimations of baseline conditions and continuous monitoring of carbon cycling and species impacts within a system. It is also predicated on garnering social support for both the reintroduction and monitoring of a species, and obtaining the animals themselves.

We are excited by the growing interest in this potential, but emphasize that a species' net impact on ecosystem carbon dynamics is context‐dependent. Caution is required whenever biodiversity conservation (including rewilding), climate change mitigation, and human welfare do not readily align. Hence—similar to other nature‐based solutions—these burgeoning efforts must avoid sweeping generalizations.

To bolster successful trophic rewilding, we highlight a range of social and ecological context dependencies that can vary outcomes in a rewilded carbon cycle and provide ethical considerations for successful implementation.

We conclude with an overview of the available technology to predict and monitor progress toward both biodiversity and climate mitigation goals.

Read the free Plain Language Summary for this article on the Journal blog.
Gratitude, optimism, and satisfaction with life and patient‐reported outcomes in patients undergoing hematopoietic stem cell transplantation
Authors: Amonoo Hermioni L. , Daskalakis Elizabeth , Deary Emma C. , Guo Michelle , Boardman Annabella C. , Keane Emma P. , Lam Jeffrey A. , Newcomb Richard A. , Gudenkauf Lisa M. , Brown Lydia A. , Onyeaka Henry K. , Lee Stephanie J. , Huffman Jeff C. , El‐Jawahri Areej 
Published: February 2024

AbstractObjectiveAssociations between positive psychological well‐being (PPWB) and patient‐reported outcomes (PROs, e.g., quality of life [QOL]) have yet to be studied extensively in patients with hematologic malignancies who are allogeneic hematopoietic stem cell transplant (HSCT) survivors, despite substantial evidence that PPWB impacts PROs of other medical populations.MethodsWe conducted a secondary analysis of cross‐sectional data examining the association of PPWB and PROs at day 100 post‐transplant among 158 allogeneic HSCT recipients. Optimism, gratitude, life satisfaction, and PROs (i.e., QOL, anxiety, depression, and PTSD symptoms) were assessed using the Life Orientation Test‐Revised, Gratitude Questionnaire, Satisfaction with Life Scale, Functional Assessment of Cancer Therapy‐Bone Marrow Transplant, Hospital Anxiety and Depression Scale, and Post‐Traumatic Stress Disorder (PTSD) Checklist‐Civilian Version, respectively. We used linear and multivariate regressions for all analyses and controlled for patient factors.ResultsOptimism was associated with better QOL (β = 1.46; p < 0.001) and lower levels of anxiety (β = −0.28; p < 0.001), depression (β = −0.31; p < 0.001), and PTSD (β = −0.58; p < 0.001). Gratitude was associated with better QOL (β = 1.11; p < 0.001) and lower levels of anxiety (β = −0.21; p = 0.001), depression (β = −0.14; p = 0.021), and PTSD (β = −0.32; p = 0.032). Finally, satisfaction with life was associated with better QOL (β = 1.26; p < 0.001) and lower levels of anxiety (β = −0.18; p < 0.001), depression (β = −0.21; p < 0.001), and PTSD (β = −0.49; p < 0.001).ConclusionOptimism, gratitude, and satisfaction with life were all associated with better QOL and lower levels of psychological distress in allogeneic HSCT survivors. These data support studies to harness PPWB as a therapeutic intervention for this population throughout HSCT recovery.
Assembly of Zinc‐Single‐Site‐Containing Silica Nanoparticles to Supraparticle Powders with Destructibility to Serve as Filler and Vulcanization Activator in Rubbers
Authors: Wenderoth Sarah , Milana Paola , Zimmermann Thomas , Deues Moritz , Oppmann Maximilian , Prieschl Johannes , Mostoni Silvia , Scotti Roberto , Wintzheimer Susanne , Mandel Karl 
Published: February 2024

AbstractThe vulcanization process is widely used in industry for tire manufacturing. Therefore, zinc oxide is commonly utilized as an activator material, but unreacted zinc oxide remains in the final products and can be released into the environment with a significant impact. To reduce the amount of required zinc and to prevent leaching from tire material, zinc single site‐containing silica fillers are interesting candidates. In these materials, zinc sites are anchored on the surface of silica nanoparticles through their complexation with functionalized aminosilanes. Based on these, a novel powder sample is prepared via spray‐drying. The obtained supraparticles allow for a homogeneous distribution of the filler nanoparticles in the rubber matrix via their disintegration during the incorporation process. All synthesis steps are carried out in ethanol and water, respectively, at very mild temperatures to account for sustainability demands. As core of this study, the role of zinc ions and their amino‐complexation in nanoparticle dispersion stability and in supraparticle formation during spray‐drying is elucidated. Additionally, the superior performance of supraparticles as activator in rubber vulcanization is demonstrated. These show a higher curing efficiency, leading to lower curing time (−70%), higher torque values (+15%), and improved dynamic mechanical properties compared to the conventional ZnO activator.
Discovery of broadly‐neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens
Authors: Rivera‐de‐Torre Esperanza , Lampadariou Stefanos , Møiniche Mark , Bohn Markus F. , Kazemi Seyed Mahdi , Laustsen Andreas H. 
Published: February 2024

AbstractBroadly‐neutralizing monoclonal antibodies are becoming increasingly important tools for treating infectious diseases and animal envenomings. However, designing and developing broadly‐neutralizing antibodies can be cumbersome using traditional low‐throughput iterative protein engineering methods. Here, we present a new high‐throughput approach for the standardized discovery of broadly‐neutralizing monoclonal antibodies relying on phage display technology and consensus antigens representing average sequences of related proteins. We showcase the utility of this approach by applying it to toxic sphingomyelinases from the venoms of species from very distant orders of the animal kingdom, the recluse spider and Gadim scorpion. First, we designed a consensus sphingomyelinase and performed three rounds of phage display selection, followed by DELFIA‐based screening and ranking, and benchmarked this to a similar campaign involving cross‐panning against recombinant versions of the native toxins. Second, we identified two scFvs that not only bind the consensus toxins, but which can also neutralize sphingomyelinase activity of native whole venom in vitro. Finally, we conclude that the phage display campaign involving the use of the consensus toxin was more successful in yielding cross‐neutralizing scFvs than the phage display campaign involving cross‐panning.
Exploring the dynamics and structure of PpiB in living Escherichia coli cells using electron paramagnetic resonance spectroscopy
Authors: Ben‐Ishay Yasmin , Barak Yoav , Feintuch Akiva , Ouari Olivier , Pierro Annalisa , Mileo Elisabetta , Su Xun‐Cheng , Goldfarb Daniella 
Published: February 2024

AbstractThe combined effects of the cellular environment on proteins led to the definition of a fifth level of protein structural organization termed quinary structure. To explore the implication of potential quinary structure for globular proteins, we studied the dynamics and conformations of Escherichia coli (E. coli) peptidyl‐prolyl cis/trans isomerase B (PpiB) in E. coli cells. PpiB plays a major role in maturation and regulation of folded proteins by catalyzing the cis/trans isomerization of the proline imidic peptide bond. We applied electron paramagnetic resonance (EPR) techniques, utilizing both Gadolinium (Gd(III)) and nitroxide spin labels. In addition to using standard spin labeling approaches with genetically engineered cysteines, we incorporated an unnatural amino acid to achieve Gd(III)‐nitroxide orthogonal labeling. We probed PpiB's residue‐specific dynamics by X‐band continuous wave EPR at ambient temperatures and its structure by double electron–electron resonance (DEER) on frozen samples. PpiB was delivered to E. coli cells by electroporation. We report a significant decrease in the dynamics induced by the cellular environment for two chosen labeling positions. These changes could not be reproduced by adding crowding agents and cell extracts. Concomitantly, we report a broadening of the distance distribution in E. coli, determined by Gd(III)–Gd(III) DEER measurements, as compared with solution and human HeLa cells. This suggests an increase in the number of PpiB conformations present in E. coli cells, possibly due to interactions with other cell components, which also contributes to the reduction in mobility and suggests the presence of a quinary structure.
A PDZ scaffolding/CaM‐mediated pathway in Cryptochrome signaling
Authors: Bellanda Massimo , Damulewicz Milena , Zambelli Barbara , Costanzi Elisa , Gregoris Francesco , Mammi Stefano , Tosatto Silvio C. E. , Costa Rodolfo , Minervini Giovanni , Mazzotta Gabriella M. 
Published: February 2024

AbstractCryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated with circadian clock regulation, implying that cryptochromes may be subject to modulation by multiple signaling mechanisms. In this study, we demonstrate that human CRY2 (hCRY2) forms a complex with the large, modular scaffolding protein known as Multi‐PDZ Domain Protein 1 (MUPP1). This interaction is facilitated by the calcium‐binding protein Calmodulin (CaM) in a calcium‐dependent manner. Our findings suggest a novel cooperative mechanism for the regulation of mammalian cryptochromes, mediated by calcium ions (Ca2+) and CaM. We propose that this Ca2+/CaM‐mediated signaling pathway may be an evolutionarily conserved mechanism that has been maintained from Drosophila to mammals, most likely in relation to its potential role in the broader context of cryptochrome function and regulation. Further, the understanding of cryptochrome interactions with other proteins and signaling pathways could lead to a better definition of its role within the intricate network of molecular interactions that govern circadian rhythms.
Population pharmacokinetics of the GIP/GLP receptor agonist tirzepatide
Authors: Schneck Karen , Urva Shweta 
Published: February 2024

AbstractTirzepatide is a first‐in‐class glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist approved as for the treatment of type 2 diabetes mellitus. A population‐based pharmacokinetic (PK) model was developed from 19 pooled studies. Tirzepatide pharmacokinetics were well‐described by a two‐compartment model with first order absorption and elimination. The tirzepatide population PK model utilized a semimechanistic allometry model to describe the relationship between body size and tirzepatide PK. The half‐life of tirzepatide was ~5 days and enabled sustained exposure with once‐weekly subcutaneous dosing. The covariate analysis suggested that adjustment of the dose regimen based on demographics or subpopulations was unnecessary. The tirzepatide PK model can be used to predict tirzepatide exposure for various scenarios or populations.
Herb‐drug interactions: A short review on central and peripheral nervous system drugs
Authors: Bernardo João , Valentão Patrícia 
Published: February 2024

AbstractHerbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb‐drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self‐limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb‐drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems. Our work draws upon a broad range of evidence, encompassing preclinical data, animal studies, and clinical case reports. We delve into the intricate pharmacodynamics and pharmacokinetics underpinning each interaction, elucidating the mechanisms through which these interactions occur. One pressing issue that emerges from this analysis is the need for updated guidelines and sustained pharmacovigilance efforts. The topic of herb‐drug interactions often escapes the attention of both consumers and healthcare professionals. To ensure patient safety and informed decision‐making, it is imperative that we address this knowledge gap and establish a framework for continued monitoring and education. In conclusion, the use of herbal remedies alongside conventional medications is a practice replete with potential hazards. This review not only underscores the real and significant risks associated with herb‐drug interactions but also underscores the necessity for greater awareness, research, and vigilant oversight in this often‐overlooked domain of healthcare.
3D Dirac Semimetal Supported Tunable Multi‐Frequency Terahertz Metamaterial Absorbers
Authors: Liu Shilin , Cao Wenhan , Jiang Shizeng , He Lianhao , Lin Fangting , He Xiaoyong 
Published: February 2024

AbstractIn recent years, 3D Dirac semimetals (DSM) with linear energy‐momentum dispersion near the Fermi points have emerged as promising material candidates for novel tunable metamaterial devices due to their prominent electromagnetic performance and excellent tunability. In this work, the propagation characteristics of 3D DSM‐supported double and triple stripe patterned metamaterial absorbers (MMAs) are investigated in the terahertz (THz) regime by facile modulation of the Fermi level. The results manifest that for the double stripe patterned devices, two strong absorption peaks with near unity are observed at 0.97 THz and 1.63 THz, respectively. When the Fermi level varies in the range of 0.01–0.15 eV, the amplitude (frequency) modulation depth of resonance is up to 77% (27.3%). Additionally, triple stripe MMAs supported by 3D DSM are devised, which can achieve resonant absorption peaks at three specific frequencies of 0.23, 0.345, and 0.46 THz, while the amplitudes of the peaks are as high as 0.997, 0.940, and 0.779, respectively. Furthermore, the resonances can also be regulated, and the amplitude MD reaches ≈20%. These results are very helpful in understanding the tuning mechanisms of metamaterial devices and aiding the design of THz functional devices, such as receivers, detectors, and modulators.
A case of coagulation factor V inhibitor induced by immune checkpoint inhibitor therapy
Authors: Haruta Yuki , Azuma Masanori , Sado Toshikatsu , Saito Ryuichi , Miyazaki Yoshimune , Noda Akihiro , Kitagawa Reina , Hori Yasutaka , Fujimoto Sayaka , Hasegawa Yoshinori , Ueda Tetsuya , Yamamura Ryosuke 
Published: February 2024

AbstractA 73‐year‐old woman with lung adenocarcinoma (cT4N3M1a: Stage IVA) was treated with atezolizumab as the eighth line of therapy. Four weeks after the fourth dose of atezolizumab, the prothrombin time (PT) and activated thromboplastin time (APTT) were prolonged. Coagulation factor V (FV) activity was decreased, and FV inhibitors were observed. There was no history of PT or APTT prolongation or bleeding before the use of atezolizumab. Atezolizumab‐induced coagulation FV inhibitor was diagnosed. After 2 weeks, the PT and APTT spontaneously normalized. FV activity improved and the FV inhibitors disappeared after 6 and 9 weeks, respectively.
Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome
Authors: Kumazawa Shiori , Saito Kazuki , Hashido Nanako , Ibi Rinko , Ishikawa Tomonori , Wakabayashi Akira , Miyasaka Naoyuki 
Published: February 2024

AbstractPurposeThis study aimed to elucidate the factors that affect the dynamics of blood D‐dimer in ovarian hyperstimulation syndrome (OHSS).MethodsWe retrospectively reviewed medical records from two hospitals and extracted data obtained during assisted reproductive technology and OHSS treatment. Blood D‐dimer levels during hospitalization were plotted against body weight. Other factors possibly related to blood D‐dimer levels were also analyzed.ResultsThe analysis included 10 patients with OHSS admitted between January 2013 and June 2023. In all patients, blood D‐dimer levels increased significantly when they convalesced from OHSS and lost weight. None of the patients showed clinical signs of thrombosis, which was confirmed using imaging tests in 8 of 10 patients. Two patients underwent cell‐free and concentrated ascites reinfusion therapy (CART), and their blood D‐dimer levels increased dramatically after the procedure.ConclusionWeight change and CART are associated with blood D‐dimer dynamics in OHSS. Our results show that elevated blood D‐dimer levels in patients with OHSS do not always represent the presence of thrombosis. Reinfusion of pooled D‐dimer in ascites may explain the D‐dimer surge during the recovery phase or after CART in these patients. Our study provides new perspectives on the clinical implications of D‐dimer during OHSS.