bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Intravenous Fluorescein Angiography and Adaptive Optics Imaging in Diabetic Retinopathy: A Prospective Case Series
Authors: Huang Ryan S. , Mihalache Andrew , Popovic Marko M. , Munn Colyn , Balas Michael , Issa Mariam , Melo Isabela Martins , Friedman Alon , Wright Tom , Yan Peng , Muni Rajeev H. 
Published: November 2023

Purpose:
To our knowledge, we present the first case series investigating the relationship between adaptive optics (AO) imaging and intravenous fluorescein angiography (IVFA) parameters in patients with diabetic retinopathy (DR).

Methods:
Consecutive patients with DR over the age of 18 years presenting to a single centre in Toronto, Canada from 2020-2021 were recruited. AO was performed with the RTX1 camera (Imagine Eyes, Orsay, France) at retinal eccentricities of 2° and 4°. IVFA was assessed with the artificial intelligence-based RETICAD system to extract blood flow, perfusion, and blood-retinal barrier (BRB) permeability at the same retinal locations. Correlations between AO and IVFA parameters were calculated using Pearson’s correlation coefficient.

Results:
Across nine cases, a significant positive correlation existed between photoreceptor spacing on AO and BRB permeability (r=0.303, p=0.027), as well as perfusion (r=0.272, p=0.049) on IVFA. When stratified by location, a significant positive correlation between photoreceptor dispersion and both BRB permeability and perfusion (r=0.770, p=0.043; r=0.846, p=0.034, respectively) was observed. Cone density was also negatively correlated with BRB permeability (r=-0.819, p=0.046).

Conclusion:
Photoreceptor spacing on AO was significantly correlated with BRB permeability and perfusion on IVFA in patients with DR. Future studies with larger sample sizes are needed to understand the relationship between AO and IVFA parameters in diverse patient populations.
Potential Benefits of Integrin αvβ3 Antagonists in a Mouse Model of Experimental Dry Eye
Authors: Yeh Shu-I , Ho Tsung-Chuan , Chu Ting-Wen , Chen Show-Li , Tsao Yeou-Ping 
Published: November 2023

Purpose:
The purpose of this study was to extensively evaluate the efficacy of integrin αvβ3 antagonists for the treatment of experimental dry eye (EDE).

Methods:
Vitronectin, an αvβ3 ligand, was used to induce tumor necrosis factor-α gene expression in human THP-1 macrophages. To induce EDE, C57BL/6 mice were housed in a low-humidity controlled environment chamber and injected subcutaneously with scopolamine for 7 days. Subsequently, αvβ3 antagonists, including RGDfD, c(RGDfD), c(RGDiD), c(RGDfK), ATN-161, SB273005, and cilengitide, were administered topically to EDE animals under controlled environment chamber conditions. Corneal epithelial damage in EDE was assessed by fluorescein staining. The density of conjunctival goblet cells and secretion of tears was measured by period acid–Schiff staining and phenol red-impregnated cotton threads, respectively. Inflammation markers, including tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-17A, and metalloproteinase (MMP)-9, in the pooled cornea and conjunctiva tissues were examined by real-time polymerase chain reaction.

Results:
The inhibitory effects of αvβ3 antagonists on the vitronectin-induced tumor necrosis factor-α gene expression and integrin-mediated inflammatory signaling were validated in THP-1 macrophages. αvβ3 antagonists ameliorated the impairment of the corneal epithelial barrier with varying therapeutic efficacies, compared with vehicle-treated mice. c(RGDfD) and c(RGDiD) significantly protected against goblet cell loss, tear reduction, and proinflammatory gene expression in EDE.

Conclusions:
Topical applications of αvβ3 antagonists yield therapeutic benefits in EDE by promoting corneal epithelial defect healing and reducing inflammation. Antagonistic targeting αvβ3 may be a novel promising strategy to treat patients with dry eye disease.
Insights Into the Functional Mechanism of Diabetic Kidney Disease Treatment with Sinensetin Based on Network Pharmacology and Molecular Docking
Authors: Zhou Yao , Wu Qi , Wang Xufang , Li Wei , Liu Qiong , Gao Kun 
Published: November 2023

ABSTRACT

Objective:
Sinensetin is an antioxidant widely used for treating various diseases; however, its function and targets in diabetic kidney disease (DKD) remain unknown. This study aimed to investigate the functional mechanism of sinensetin in DKD using network pharmacological and molecular docking methods.

Methods:
Potential targets of sinensetin for DKD treatment were identified using the Swiss Target Prediction (http://www.swisstargetprediction.ch/), STITCH (http://stitch.embl.de/), Online Mendelian Inheritance in Man (OMIM, https://omim.org/), and GeneCards (https://www.genecards.org/) databases. These potential targets were introduced into the STRING database to analyze protein–protein interactions (PPI) and identify key targets. These key targets were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The binding activities of these key targets were confirmed using molecular docking analysis.

Results:
A total of 53 key targets of sinensetin treatment in DKD were identified. Ten core targets, including protein kinase SRC (SRC), epidermal growth factor receptor (EGFR), and prostaglandin-endoperoxide synthase 2 (PTGS2) were identified using PPI network interactions. GO functional analysis revealed that reactive oxygen species metabolic processes, membrane rafts, and protein tyrosine kinase activity were involved in sinensetin treatment of DKD. The KEGG enrichment analysis exhibited that signaling pathways such as pathways in cancer, tryptophan metabolism, and the vascular endothelial growth factor (VEGF) signaling pathway play important roles. Molecular docking analysis suggested favorable docking between the ten core targets and sinensetin.

Conclusion:
Sinensetin plays a role in the treatment of DKD through various biological processes and signaling pathways. These data provide theoretical evidence for experimental studies on DKD treatment using sinensetin.
Evaluation of statistical correction strategies for corneal back surface astigmatism with toric lenses: a vector analysis
Authors: Langenbucher Achim , Hoffmann Peter , Cayless Alan , Wendelstein Jascha , Szentmáry Nóra 
Published: November 2023

Purpose:
To compare actual and formula-predicted postoperative refractive astigmatism using measured posterior corneal power measurements and 4 different empiric posterior corneal astigmatism correction models.

Setting:
Tertiary care center.

Design:
Single-center retrospective consecutive case series.

Methods:
Using a dataset of 211 eyes before and after tIOL implantation (Hoya Vivinex), IOLMaster 700 (IOLM) or Casia2 (CASIA) keratometric and front/back surface corneal power measurements were converted to power vector components C0 (0/90 degrees) and C45 (45/135 degrees). Differences between postoperative and Castrop formula predicted refraction at the corneal plane using the labeled parameters of the tIOL and the keratometric or front/back surface corneal powers were recorded as the effect of corneal back surface astigmatism (BSA).

Results:
Generally, the centroid of the difference shifted toward negative C0 values indicating that BSA adds some against the rule corneal astigmatism (ATR). From IOLM/CASIA keratometry, the average difference in C0 was 0.39/0.32 diopter (D). After correction with the Abulafia-Koch, Goggin, La Hood, and Castrop nomograms, it was −0.18/−0.24 D, 0.27/0.18 D, 0.13/0.08 D, and 0.17/0.10 D. Using corneal front/back surface data from IOLM/CASIA, the difference was 0.18/0.12 D.

Conclusions:
The Abulafia-Koch method overcorrected the ATR, while the Goggin, La Hood, and Castrop models slightly undercorrected ATR, and using measurements from the CASIA tomographer seemed to produce slightly less prediction error than IOLM.
Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice
Authors: Norris Makenzie R. , Becker Léa J. , Bilbily John , Chang Yu-Hsuan , Borges Gustavo , Dunn Samantha S. , Madasu Manish K. , Vazquez Chayla R. , Cariello Solana A. , Al-Hasani Ream , Creed Meaghan C. , McCall Jordan G. 
Published: November 2023

Abstract
Neuropathic pain causes both sensory and emotional maladaptation. Preclinical animal studies of neuropathic pain-induced negative affect could result in novel insights into the mechanisms of chronic pain. Modeling pain–induced negative affect, however, is variable across research groups and conditions. The same injury may or may not produce robust negative affective behavioral responses across different species, strains, and laboratories. Here, we sought to identify negative affective consequences of the spared nerve injury model on C57BL/6J male and female mice. We found no significant effect of spared nerve injury across a variety of approach-avoidance conflict, hedonic choice, and coping strategy assays. We hypothesized these inconsistencies may stem in part from the short test duration of these assays. To test this hypothesis, we used the homecage-based Feeding Experimentation Device version 3 to conduct 12-hour, overnight progressive ratio testing to determine whether mice with chronic spared nerve injury had decreased motivation to earn palatable food rewards. Our data demonstrate that despite equivalent task learning, spared nerve injury mice are less motivated to work for a sugar pellet than sham controls. Furthermore, when we normalized behavioral responses across all the behavioral assays we tested, we found that a combined normalized behavioral score is predictive of injury state and significantly correlates with mechanical thresholds. Together, these results suggest that homecage-based operant behaviors provide a useful platform for modeling nerve injury-induced negative affect and that valuable pain-related information can arise from agglomerative data analyses across behavioral assays—even when individual inferential statistics do not demonstrate significant mean differences.
Effect of Drinking Pattern on the Quality of Sleep Among Korean Male Adults Below 65 Years
Authors: Jeong Yeo Won , Oh Juyeon 
Published: November 2023

Abstract
This study aimed to analyze the differences in sleep quality according to drinking patterns and identify factors associated with poor sleepers among Korean male adults younger than 65 years. Data from 68,711 male participants from the Korean Community Health Survey collected in Korea in 2018 were analyzed. After dividing them into binge drinking and nonbinge drinking groups, each group was further categorized into three subgroups according to the frequency of drinking: less than occasionally, frequent, and very frequent. The quality of sleep and depression were assessed through face-to-face interviews using the Pittsburgh Sleep Quality Index and the Patient Health Questionnaire-9, respectively. Total sleep quality was the lowest in the group that participated in “very frequent” binge drinking; the groups that participated in “frequent” binge drinking and “very frequent” nonbinge drinking had similar levels of sleep quality. Poisson regression with robust variance analysis revealed an almost 50% higher prevalence of poor sleep in the “very frequent” binge drinking group (prevalence ratio = 1.49, p < .001) compared with the reference group (nonbinge drinking, less than occasionally) after controlling for confounding variables. Significantly higher prevalence ratios of poor sleep were found in the “frequent” and “very frequent” drinking groups compared with the reference group. Health policies could emphasize the importance of reducing one's frequency and amount of drinking. In addition, it is also necessary for healthcare professionals to assess drinking patterns when caring for people experiencing poor quality sleep and support them in correcting such drinking behaviors.
Substance Abuse Stigma
Authors: Fetterhoff Kelly 
Published: November 2023

Abstract
Substance abuse stigma is a social phenomenon that negatively impacts individuals who use illicit substances or alcohol. This stigma includes the derogatory terms used to describe people who use substances; perceptions that individuals with alcohol and substance use disorder are dangerous, immoral, and of weak character; and the public blaming of the addicted people for their addiction. Substance abuse took the life of over 100,000 Americans between 2020 and 2021, and one identified barrier to treatment is the stigma associated with substance abuse. When someone is ashamed, they are less likely to seek treatment, and when someone is seeking help and is greeted with negative preconceptions, they are again deterred from treatment. The stigma exists in multiple layers of society including the general public, policy makers, the police, doctors, and nurses and within the person using the substance. The purpose of this article is to define substance abuse stigma in multiple contexts and explore its effects on treatment.
What Can Customers See? Exposed Information on E-Cigarette Online Retail Website
Authors: Zhou Yanjun , Kwon Misol , Park Eunhee , Chang Yu-Ping 
Published: November 2023

Abstract

Background
The internet is the main channel for electronic nicotine delivery systems sales that the media uses to publicize electronic cigarettes (e-cigarettes). Once e-cigarettes entered the market, they quickly became widely available online and in retail stores in many countries and regions around the world. This systematic review aims to explore the online marketing strategies for e-cigarette retail websites including the design of e-cigarette retail websites and how the information of retail websites was exposed to the public.

Method
Studies were searched in five databases: Cumulative Index to Nursing and Allied Health Literature, EMBASE, Web of Science, Communication & Mass Media Complete, and PubMed. Included studies were published between 2007 and 2019.

Results
Eight studies were included in this review. Topics covered included smoking cessation claims, nicotine content claims, health or harmful substance exposure claims, age restriction/verification, membership and discounts, and media and celebrity effect. Most of the claims included information about the benefits of e-cigarettes, such as helping to quit smoking, being more environmentally friendly than traditional paper cigarettes, and not containing nicotine. Common marketing techniques included celebrity endorsements, showing discounts or membership offers, or getting a link to buy from the media.

Conclusions
The marketing of e-cigarettes is complex, and the authenticity of the information presented on the websites needs to be thoroughly understood. Such information will undoubtedly increase the interest and desire of potential buyers for e-cigarettes. Therefore, it is critical to establish necessary regulations regarding e-cigarette product information.
Perceived Stressors and Support in Family Caregivers of Individuals With Opioid Use Disorder
Authors: Tyo Mirinda B. , McCurry Mary K. , Horowitz June Andrews , Elliott Kathleen 
Published: November 2023

Abstract
Stress experienced by family caregivers of individuals with opioid use disorder (OUD) contributes to caregiver burden. To understand the stressors experienced by family caregivers of individuals with OUD and the factors that influence their personal resiliency, data were collected from a convenience sample of family caregivers who answered two open-ended questions about sources of stress and factors that affect their personal resilience as part of an online survey. Yin's thematic analysis revealed five objective and two subjective burden themes and four resilience themes. Results indicate OUD places significant burden on families and may contribute to decreased physical and mental well-being in caregivers. Caregivers who perceived adequate support were able to use their experience and innate knowledge to cope and emerge with more resilience. Results of this study support the need for translational research to increase resilience and coping in this population of caregivers.
The Effect of Using a Normothermia Checklist on Awakening Time From Anesthesia and Coagulation Disorder: A Randomized Controlled Trial
Authors: YILMAZ EKER Pinar , YILMAZ Meryem 
Published: November 2023

ABSTRACT

Background
Inadvertent perioperative hypothermia (IPH) is a common issue in surgical patients. To avoid this issue, the patient should be monitored continuously throughout the perioperative process. Evidence-based practices in line with relevant guidelines are necessary to maintain normothermia.

Purpose
This study was developed to determine the effect of using a control list developed for preventing IPH on time of awakening from anesthesia and coagulation disorder in surgical patients.

Methods
In this randomized controlled study, nursing interventions were applied to patients in accordance with the normothermia checklist (NC) developed by the researchers to prevent IPH.

Results
In this study, 30 patients were respectively assigned to the experimental and control groups. Conducting nursing interventions in accordance with the control checklist was found to be effective in preventing IPH. Moreover, time of awakening from anesthesia was significantly shorter in the experimental group (3.77 ± 1.10 minutes) than the control group (11.03 ± 2.51 minutes; p < .05). Furthermore, tendency to bleed was higher in the control group than the experimental group, and a statistically significant between-group difference in coagulation disorders was found (p < .05).

Conclusions/Implications for Practice
The results of this evidence-based study indicate that implementing nursing interventions in line with the developed NC is effective in preventing IPH. Preventing IPH, which increases the risk of numerous complications in surgical patients, is an important responsibility of nurses. Nurses may employ the NC proposed in this study to better secure the safety and minimize the risk of complications in surgical patients.
Examining the Effect of SARS-CoV-2 Pandemic-Induced Stress and Anxiety on Humoral Immunity in Health Care Workers
Authors: Stark Valerie S. , Williams Erin C. , Echeverri Tribin Felipe , Coto Jennifer , Carrico Adam , Carreño Juan Manuel , Bielak Dominika , Desai Parnavi , Krammer Florian , Hoffer Michael E. , Pallikkuth Suresh , Pahwa Savita 
Published: November 2023

Objective
The effect of stress on vaccine-induced humoral immunity and therapeutic interventions to mitigate pandemic-related stress remain underexplored.

Method
Participants in a longitudinal cohort study (n = 189) completed a validated measure, GAD-7, and 10-instrument stress measure to assess stress and anxiety after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Serum was collected to obtain SARS-CoV-2 antibody titer levels.

Results
Participants experienced increased stress due to the SARS-CoV-2 pandemic with a positive correlation between GAD-7 scores and peak antibody titers overall; however, there was a negative association with scores commensurate with severe anxiety. Health care workers and younger participants were more significantly affected by anxiety.

Conclusions
Mild anxiety levels may have immune-enhancing effects, whereas severe anxiety may cause antibody generation reduction. Mental health–focused interventions are imperative for younger adults and health care workers. Young adults may be more resilient to increased stress levels.
The Impact of Personal Protective Equipment on Cognitive and Emotional Aspects of Health Care Work
Authors: Judd Belinda K. , Whelehan Dale F. , Baysari Melissa T. , Baillie Andrew J. 
Published: November 2023

Objective
Personal protective equipment (PPE) is critical to the safety of health professionals and vital to clinical practice. However, there is little known about the cognitive and emotional impact of PPE on health professionals’ performance, comfort, and well-being.

Methods
A mixed-method, cross-sectional, observational study was adopted. An online survey consisting of 5-point Likert scale questions and free-text comments canvassed the opinions of patient-facing health professionals.

Results
An overall negative impact of PPE on health professionals’ ability to carry out work was found from 185 responses from medicine, nursing, and allied health disciplines, including increased fatigue, poor communication, and feeling uncomfortable.

Conclusions
There are significant negative impacts of PPE on health professionals’ ability to carry out work, impairing communication, task efficiency, and comfort. Personal protective equipment is an essential infection control practice requiring further research, design, and testing to overcome challenges.
Safety and effectiveness of totally laparoscopic total gastrectomy vs laparoscopic-assisted total gastrectomy: a meta-analysis
Authors: Wu Qishuan , Wang Yan , Peng Qifan , Bai Mingshuai , Shang Zhou , Li Leping , Tian Feng , Jing Changqing 
Published: November 2023

Background:
For gastric cancer with total gastrectomy, the usual laparoscopic surgical approaches are totally laparoscopic total gastrectomy (TLTG) and laparoscopic-assisted total gastrectomy (LATG). Due to its difficult anastomotic technique, the adoption of TLTG is limited. Therefore, surgeons prefer using LATG, which also led to TLTG being somewhat overlooked, so there is no clear conclusion today as to which surgical procedure is more favorable to the patient’s recovery. This article aimed to compare the safety and short-term outcomes of the two surgical approaches.

Materials and methods:
Studies comparing TLTG and LATG, published up to December 2022, were searched in PubMed, Web of Science, and Embase databases. The study outcomes, including operative time, blood loss, anastomosis time, number of retrieved lymph nodes, proximal and distal resection margins, time to first fluid and soft diet, hospitalization duration, time to first flatus, and postsurgical and anastomotic complications, were compared between these two different surgical procedures. Statistics were analyzed with RevMan 5.4 and Stata 13.1.

Results:
Fifteen publications were included in this study. The total sample included 3023 cases. The meta-analysis revealed no significant difference in overall postoperative complications between the two surgical approaches (P>0.05). Compared with LATG, TLTG led to reduced intraoperative blood loss (P<0.0001), an increased number of lymphatic node dissections (P<0.0001), and decreased hospitalization duration (P=0.002). However, operative time, anastomosis time, pulmonary infection, resection margins, time to first fluid and soft diet, time to first flatus and anastomosis-related complications were no significant difference between TLTG and LATG groups (P>0.05).

Conclusion:
TLTG did not lead to an increase in overall postoperative complications, which is a reliable surgical approach for treatment of gastric cancer. Moreover, it may reduce harm to patients and enable them to obtain better surgical outcomes.