bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical RXLR effectors are involved in Phytophthora cactorum pathogenesis
Authors: Zheng Zeyang , Liu Juanjuan , You Wenzhong , Sun Jun , Wang Kehan , Zhang Xuemei , Yan Xinyu , Liu Zhenpan 
Published: January 2025

Abstract
RXLR effectors are pathogenic factors secreted from oomycetes to manipulate the immunity of the host. Typical RXLR effectors contain an RXLR-dEER motif at the N-terminus, whereas atypical RXLRs show variations on this motif. The oomycete Phytophthora cactorum is known to infect over 200 plant species, resulting in significant agricultural economic losses. Although genome-wide identification and functional analyses of typical RXLRs from P. cactorum have been performed, little is known of atypical PcaRXLRs. Here, we identified RXLRs, both typical and atypical, in P. cactorum and compared them with those of other oomycete pathogens. Fewer RXLRs were identified in P. cactorum compared with other Phytophthora species, possibly due to fewer duplication events of RXLRs. In contrast, the percentage of atypical RXLRs was higher in P. cactorum than in other species, suggesting significant roles in P. cactorum pathogenesis. Analysis of RXLR gene expression showed that most were transcribed, suggesting their functionality. Transient expression of two atypical RXLRs in Nicotiana benthamiana showed that they induced necrosis dependent on host SGT1 and HSP90. Furthermore, two additional atypical RXLRs suppressed the defense response in N. benthamiana and promoted P. cactorum infection. These results demonstrate the vital role of atypical RXLRs in P. cactorum and provide valuable information on their evolutionary patterns and interactions with host plants.
Genomic evidence for demographic fluctuations, genetic burdens and adaptive divergence in fourfinger threadfin Eleutheronema rhadinum
Authors: Xiao Jie , Wang Wen-Xiong 
Published: January 2025

Abstract
Declining populations and bottlenecks lead to the accumulation of deleterious mutations in fish populations. These processes also trigger genetic purging, which is a key genetic factor in reducing the deleterious burdens and increasing population viability. However, there is a lack of empirical evidence on the interaction between demographic history and the genome-wide pattern of deleterious variations. Here, we generated genome resequencing data of Eleutheronema rhadinum from China and Thailand, representing the major distribution of the species’ southern regions. E. rhadinum had exceptionally low genome-wide variability and experienced dramatic population expansions followed by continuous declines. The geographical divergence, which occurred ~ 23,000 years ago, shaped different demographic trajectories and generated different regional patterns of deleterious mutations in China and Thailand populations. Several lines of evidence revealed that this geographical pattern of deleterious mutation was driven by the purging of highly deleterious mutations. We showed that purifying selection had inbreeding-associated fitness costs and was more efficient against missense mutations in the Thailand population, which had the lowest genetic burden of homozygous deleterious mutations. Multiple evolutionarily conserved protein domains were disrupted by the loss-of-function mutations, posing a high probability of gene functionality elimination. Moreover, thermal and salinity genes (Trpm3, Nek4, Gtf2f2, Cldn14) were identified in genomic divergence regions of E. rhadinum among China and Thailand populations. Our findings highlight the importance of demographic history factors shaping the geographical patterns of deleterious mutations. The results serve to deepen our understanding of the adaptive evolution and divergence of E. rhadinum with implications for other marine fish.
Seawater-mixed concretes containing supplementary cementitious materials: compressive strength, e-modulus, electrical resistivity, and life cycle assessment
Authors: Rathnarajan Sundar , Pacheco Joao Nuno , Capucha Francisco , Valencia Javier , Techman Mateusz , Sikora Pawel 
Published: January 2025

Abstract
Water and concrete are the materials humans consume the most on earth. By 2040, several countries are expected to face extreme water stress and the need for significant growth in their infrastructure simultaneously. Water is a fundamental ingredient for concrete production, and the need for infrastructure growth can further increase the water demand for concrete production and thus affect these regions facing water scarcity. Including supplementary cementitious materials (SCMs), non-metallic fibres, and coated/polymer reinforcements can increase the feasibility of producing concrete with seawater (SW). There is a lack of information on the long-term strength and durability properties of SW-mixed concretes (SWC) produced with SCMs. This paper optimises binder compositions with CEM I, fly ash, ground granulated blast furnace slag (slag), and metakaolin suitable for adapting SWC based on performance indicators. Binary and ternary blended concretes of similar binder content (360 kg/m3) and w/b (0.45) were designed and cast with the SCMs mentioned above. Compressive strength, surface resistivity, and accelerated carbonation tests were conducted on the concrete produced with freshwater (FW) and seawater (SW). SWC produced with 30% slag and 15% metakaolin had higher electrical resistivity and an improvement in compressive strength (up to 30%) than other combinations used for producing SWC. Life cycle assessment identified that the concretes produced with fly ash, and ternary combination of fly ash and metakaolin had the least water depletion potential (WDP) compared to other SW-mixed concretes. Also, the replacement of FW by SW reduces the WDP up to 50%.
Improving fire resistance of lightweight concrete facade elements by using fibers
Authors: Beytekin Hatice Elif , Kaya Yahya , Mardani Ali , Sezer Filiz Şenkal 
Published: January 2025

Abstract
It is known that the most critical factor affecting fire resistance requirements in buildings is the building envelope, and therefore, improving the thermal properties of facade materials has become an important research area. In this context, studies examining the high temperature resistance properties of various facade materials have indicated that concrete has higher heat resistance compared to many facade materials. Lightweight concrete facade elements stand out for their structural durability and fire resistance at high temperatures. However, the different thermal expansion coefficients of aggregates and cement paste in concrete mixtures can lead to adverse outcomes under high temperatures, such as cracking or structural degradation. To mitigate these adverse effects, it has been suggested that adding fibers to lightweight concrete mixtures could enhance durability and improve fire resistance. This study investigated the effects of different fiber types, lengths, and usage rates on the high temperature resistance of lightweight concrete mixtures. In the experimental study, three different types of fibers—polypropylene, polyamide, and glass—were used in varying proportions of 0%, 0.25%, 0.5%, and 0.75% of the total volume. Polypropylene fibers were included at lengths of 3, 6, and 12 mm; polyamide fibers at 6 and 12 mm; and glass fibers at 13 and 25 mm. When observing the behavior of the mixtures under high temperatures, it was noted that mixtures with glass fibers performed best at 300 °C, while those with polypropylene fibers showed superior performance at 600 °C. This demonstrates the advantages of glass and polypropylene fibers in providing resilience at different temperature ranges. Furthermore, the optimal fiber usage rate for high temperature resistance was determined to be 0.25%. These findings highlight the importance of considering factors such as fiber type, length, and usage rate in the development of fire-resistant facade materials.
Bomb radiocarbon dating and age estimation of European eel (Anguilla anguilla) of Norway
Authors: Andrews Allen H , Welte Caroline , Mihaljevic Marina , Durif Caroline M F 
Published: January 2025

Abstract
Age estimates from bomb 14C dating conflict with a well-recognized age reading protocol (grinding, polishing and staining in the sagittal plane) for otoliths of European eel (Anguilla anguilla). Proper alignment of calculated hatch years for 14C measurements taken from the earliest otolith growth—among the smallest otolith extractions to date for successful 14C analysis due to the advent of gas-AMS—was not achieved using age estimates from an accepted method. The realignment of otolith 14C values to a tropical bomb 14C reference chronology, which is most applicable to the Sargasso Sea as the natal origin of European eel, led to an increase of the original age estimates by 8 to 32 years. A maximum age of approximately 46 years was determined for the European eel specimen with the most massive otolith, of which mass is a reasonable proxy for age and was instrumental in identifying age estimate discrepancies. By extending the otolith mass-to-age relationships from this study to the most massive otoliths available from archived otoliths of Norway, an increase of up to several decades from the original otolith age estimates was discovered, leading to support for a potential lifespan of 70–100 years in the natural environment.
Carotid intima medial thickness and its association with cardiometabolic risk factors in children with overweight and obesity: a hospital-based cross-sectional study
Authors: Sasidharan Pillai Sabitha , Vijayakumar M. , Balakrishnan Ajitha 
Published: January 2025

Abstract
A hospital-based cross-sectional study involving children aged 2–15 years attending the obesity clinic of a tertiary care hospital from January 2016 to March 2018 was carried out to study carotid intima media thickness (cIMT) and its association with cardiometabolic risk factors in children with overweight and obesity. Secondary objective was to compare children with elevated (EcIMT) and normal cIMT (NcIMT). Out of 223 patients enrolled for the study, 102 (45·7 %) had EcIMT. Mean cIMT of the study participants was 0·41 (sd 0·13) mm. Median alanine transaminase levels (27 v. 24, P= 0·006) and proportion of patients with fatty liver (63·7 % v. 48·8 %, P= 0·025) and ≥ 3 risk factors (80·4 % v. 66·1 %, P= 0·003) were higher in the EcIMT group compared with NcIMT group. Proportion of patients with hypercholesterolemia (36·4 % v. 16 %, P= 0·024), elevated LDL-cholesterol (38·6 % v. 16 %, P= 0·013), low HDL-cholesterol (40·9 % v. 20 %, P= 0·027) and dyslipidemia (84·1 % v. 58 %, P= 0·006) was higher in the pubertal EcIMT group and those with fatty liver (63·8 % v. 45·1 %, P= 0·034) was higher in the prepubertal EcIMT group compared with pubertal and prepubertal NcIMT groups, respectively. No significant correlations were observed between cIMT and various cardiometabolic parameters. Our finding of EcIMT in nearly half of the study participants including young children is very concerning as these children are at increased risk of atherosclerotic CVD in adulthood. Interventions starting at a young age are important when trajectories are likely to be more malleable and adverse cardiometabolic phenotypes and subclinical atherosclerosis are reversible.
In vitro digested ingredients as substitute for ileal digesta in assessing protein fermentation potential in growing pigs
Authors: Zhang Hanlu , Cone John W. , Kies Arie K. , Hendriks Wouter H. , van der Wielen Nikkie 
Published: January 2025

Abstract
Understanding protein fermentation in the hindgut of pigs is essential due to its implications for health, and ileal digesta is commonly used to study this process in vitro. This study aimed to assess the feasibility of utilising in vitro digested residues as a replacement for ileal digesta in evaluating the protein fermentation potential. In vitro residues from cottonseed meal, maize germ meal, peanut meal, rapeseed cake, rapeseed meal, soyabean meal and sunflower meal were analysed using a modified gas production (GP) technique and curve fitting model to determine their fermentation dynamics and compare with the use of ileal digesta. Significant variations were observed in GP parameters between in vitro digested residues, indicating differences in nitrogen utilisation by fecal microbiota. Soyabean meal and sunflower meal exhibited the highest maximum GP rates (Rmax), with values of 29·5 ± 0·6 and 28·0 ± 1·2 ml/h, respectively, while maize germ meal showed slowest protein utilisation (17·3 ± 0·2 ml/h). A positive relationship was found between the Rmax of in vitro residues and ileal digesta (R2 = 0·85, P < 0·01). However, GP potential (GPs) showed a tendency for a negative relationship (R2 = 0·39, P < 0·1), likely due to narrow observed GPs values and the presence of varied endogenous proteins in ileal digesta. Our results demonstrate the potential of using in vitro digested residues as a substitute for ileal digesta in assessing the fermentation potential of protein ingredients, particularly regarding the rate of protein fermentation.
Pensions: more than collective risk pooling?
Authors: Schokkaert Erik 
Published: January 2025

AbstractI agree that a good pensions system should embody some form of collective risk pooling and that this would be to the advantage of everyone. There are some difficult issues of adverse selection to be solved, however. Moreover, egalitarian concerns are of crucial importance in most countries and they require to go further than collective risk pooling and to take into account that society is more than a system of self-interested monetary transfers between and within cohorts.
Two kinds of social cooperation?
Authors: Karnein Anja 
Published: January 2025

AbstractMichael Otsuka argues that collective pension schemes are forms of social cooperation on equal terms for mutual advantage and thus, matters of social justice. In this way Otsuka wants to understand collectively funded pensions in Rawlsian terms. I argue that not all forms of social cooperation are the same and that the specific kind of social cooperation Rawls has in mind is, in at least three central respects, different from the kind of social cooperation involved in the collective pension schemes Otsuka describes.
Machine learning models for sequential motion recognition in human activity for logistics operations efficiency improvement
Authors: Cheng Chih-Feng , Lin Chiuhsiang Joe , Hu Qin-Xuan 
Published: January 2025

Abstract
Human activity recognition (HAR) is a vital component of human–robot collaboration. Recognizing the operational elements involved in an operator’s task is essential for realizing this vision, and HAR plays a key role in achieving this. However, recognizing human activity in an industrial setting differs from recognizing daily living activities. An operator’s activity must be divided into fine elements to ensure efficient task completion. Despite this, there is relatively little related research in the literature. This study aims to develop machine learning models to classify the sequential movement elements of a task. To illustrate this, three logistic operations in an integrated circuit (IC) design house were studied, with participants wearing 13 inertial measurement units manufactured by XSENS to mimic the tasks. The kinematics data were collected to develop the machine learning models. The time series data preprocessing involved applying two normalization methods and three different window lengths. Eleven features were extracted from the processed data to train the classification models. Model validation was carried out using the subject-independent method, with data from three participants excluded from the training dataset. The results indicate that the developed model can efficiently classify operational elements when the operator performs the activity accurately. However, incorrect classifications occurred when the operator missed an operation or awkwardly performed the task. RGB video clips helped identify these misclassifications, which can be used by supervisors for training purposes or by industrial engineers for work improvement.
Some Acts Really Harm: A Defense of the Standard Account versus Norcross's Contextualism
Authors: Eggleston Ben 
Published: January 2025

AbstractAn important strand of argument in Alastair Norcross's Morality by Degrees: Reasons without Demands is the rejection of the standard account of harm, which underwrites non-comparative statements of the form “act A harms person X.” According to Norcross, the correct account of harm is a contextualist one that only underwrites comparative statements of the form “act A results in a worse world for X than alternative act B, and a better world than alternative act C.” This article criticizes Norcross's contextualist account and his rejection of the standard account. It follows that moral theorists of all kinds should not be deterred by Norcross's arguments from continuing to rely on the standard account and using it to non-comparatively categorize some acts as harmings.
Assessment of quality of life and psychosocial problems in children with Congenital Heart Disease
Authors: Bulbul Oztoprak Meral , Bilici Meki , Dogac Tugba , Akin Alper , Ture Mehmet , Balik Hasan , Yilmaz Kamil , Satıcı Omer , Emir Busra 
Published: January 2025

AbstractObjective:Congenital heart disease (CHD) is a condition that can significantly impact health-related quality of life due to the need for long-term follow-up and treatment. The purpose of this study was to analyse the quality of life of children diagnosed with CHD and to assess the relationship between the disease and their physical and mental well-being.Materials and Methods:The study involved 180 patients and 180 healthy controls. Both groups were divided into three age categories (5–7 years, 8–12 years, and 13–18 years), with 60 children in each age group. The researchers administered the Pediatric Quality of Life Inventory (PedsQL) to the participants, taking into account their age.Results:Comparisons between the patient and control groups showed that the patient group had significantly lower scores than the control group in terms of total quality of life scale score, physical health score, and psychosocial health score of the Pediatric Quality of Life Inventory (p < 0.001, p < 0.001, and p < 0.001). Quality of life was also compared between patients receiving and not receiving medication treatment. Patients receiving medication treatment had lower scores for total quality of life score, physical health score, and psychosocial health score of the Pediatric Quality of Life Inventory compared to the control group (p < 0.001, p = 0.005, and p < 0.001).Conclusion:Children with CHD experience a negative impact on their quality of life. Given the extended life expectancy resulting from new treatment options, it is important to monitor these children both physically and psychosocially and to implement activities aimed at improving their quality of life.
Frequency-dependent regime-switching in VAR models
Authors: Hwang Youngjin 
Published: January 2025

Abstract
This study presents a simple frequency-dependent regime-switching vector autoregression (VAR) model, where each regime and its associated parameters in the VAR are characterized by their distinct spectral properties. Empirical applications to several key macroeconomic variables reveal clear frequency-dependent switching dynamics, with each regime exhibiting distinctive features regarding spectral properties, volatility, and impulse responses. We compare this model with a conventional regime-switching model (typically studied in the time domain) and highlight several key differences between the two approaches.
Andean Primordial Titles, Land Repossession, and the Rise of New Communities during the First General Land Inspection (1594–1602)
Authors: de la Puente Luna José Carlos 
Published: January 2025

AbstractThis essay presents the first comprehensive analysis of a series of land deeds prepared by the Laraos of Yauyos, Peru, during the First General Land Inspection to secure title to farm- and pasturelands. Scholars have shown the centrality of this first general inspection for the country’s agrarian history, but almost invariably reducing it to the appropriation of native lands and the formation of colonial rural estates. Many works have explored the mechanisms by which Spanish actors secured title to formerly indigenous lands during the Inspection, the start of a process that has been recently termed “the great dispossession.” Much less attention has been placed, however, on the strategies of native Andean commoner groups that not only used the Land Inspection to protect their holdings but also relied on it to break away from their original villages, acquire new lands, establish new settlements, and accrue recognition as independent communities. Through the analysis of the Laraos primordial titles, I show that, key in this process was the collection of narratives and the performance of walkabouts that, when committed to writing in the form of title-maps and witness testimonies, gave communities-in-the-making the necessary tools to succeed in these self-directed projects of commoner colonization.
Global Distribution of Serpentine on Mars
Authors: Emran A. , Tarnas J. D. , Stack K. M. 
Published: January 2025

AbstractThe distribution and origin of serpentine on Mars can provide insights into the planet's aqueous history, habitability, and past climate. In this study, we used dynamic aperture factor analysis/target transformation applied to 15,760 images from the Compact Reconnaissance Imaging Spectrometer for Mars, followed by validation with the radiance ratio method, to construct a map of Mg‐serpentine deposits on Mars. Although relatively rare, Mg‐serpentine was detected in diverse geomorphic settings across Noachian and Hesperian‐aged terrains in the southern highlands of Mars, implying that serpentinization was active on early Mars and that multiple formation mechanisms may be needed to explain its spatial distribution. We also calculated the amount of H2 produced during the formation of the observed deposits and conclude that serpentinization was likely more widespread on Mars than indicated by the observed distribution.
Frequency of Synoptic‐Scale Precipitation Events Recorded by Daily Resolved δ18O of Land Snail Shells
Authors: Wang Guozhen , Dong Jibao , Zhang Qian , He Sheng , Liu Chengcheng , Luo Fan , Jia Yana , Zong Xiulan , He Miaohong , Han Tao , Xue Gang , Li Yang , Dodson John , Yan Hong 
Published: January 2025

AbstractLand snails exhibit the potential for capturing synoptic‐scale precipitation events through the δ18O records of their shells (δ18Oshell), but the application is hindered by the absence of a practical methodology for tracking these events. Here, we developed a statistical methodology to track the synoptic‐scale precipitation events from daily resolved snail body fluid δ18O (δ18OBF) record. We further tested and verified our approach using daily resolved δ18Oshell records of modern Cathaica fasciola from the Chinese Loess Plateau (CLP). The reconstructed 3‐day‐timescale precipitation events frequencies using first derivations of δ18OBF and δ18Oshell shows strong agreement with instrumental data (>85% detection accuracy). The strong correlation between precipitation days in snail‐growing‐season and annual precipitation amounts across the CLP also permits the reconstruction of synoptical precipitation frequency for investigating the interannual variability of precipitation. Our study paves the avenue in paleoweather study, enabling quantitative reconstructions of past synoptic‐scale precipitation events.