bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution
in the Management of Dermal Disorders, Topical Delivery, Future Trends and
Challenges
Authors: Ahuja Ashima , Bajpai Meenakshi 
Published: January 2024

Abstract:
Nanocosmetics have attracted a considerable audience towards natural care due to their low cost,
target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including
nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored
for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry demands innovative
and personalized products designed using nanocarriers for better targeting and improving patient
compliance. Furthermore, nanocosmetics increase the efficiency of skin permeation active ingredient entrapment,
providing better UV protection. Moreover, it offers controlled drug release, targeting active sites and
enhancing physical stability. Further, overcoming the drawback of penetration problems makes them sustainable
formulations for precision medicine. Skincare nourishment with nanocosmetics using Indian spices helps
to maintain, beautify, and rejuvenate human skin. Nanophytopharmaceuticals extracted from plants, including
alkaloids, flavonoids, antioxidants, and volatile oils, are essential phyto-products for skin care. Nano herbals
and nanocosmetics are a growing market and gift of nature that nourishes and cures skin ailments like acne,
pemphigus, anti-aging, albinism, psoriasis, and fungal infections. The emerging concern is highlighted in the
investigation of nanoformulation toxicity and safety concerns in skin care. Further, it helps to manifest research,
development, and innovation in expanding the scope of herbal industries.
TPGS-mediated Transethosomes Enhance Transdermal Administration of Curcumin via Effects on Deformability and Stability
Authors: Guo Teng , Zhang Chenming , Chen Yuling , Wu Yihan , Liu Zhenda , Zhang Yongtai , Feng Nianping 
Published: January 2024

Background:
Adding a suitable surfactant can enhance the transdermal permeability of
transethosomes while also leveraging its functionality as a functional material. In this study,
transethosomes were prepared using D-α-tocopherol acid polyethylene glycol succinate (TPGS) as
edge activators for transdermal delivery of curcumin (Cur).

Methods:
The TPGS-mediated curcumin-loaded transethosomes (Cur@TES) were prepared and
formulated optimally, and the optimized formulations were characterized for their morphology, particle
size, entrapment efficiency (EE) and drug loading (DL). The stability and deformability of
Cur@TES were investigated, while the transdermal delivery of Cur@TES was investigated through
in vitro transdermal assays and fluorescence imaging. A mouse ear swelling model was performed to
determine the anti-inflammatory effect of Cur@TES.

Results:
Cur@TES appeared round or elliptical in shape. The particle size, EE and DL for the optimized
formulation were observed as 131.2 ± 7.2 nm, 97.68 ± 2.26%, and 6.58 ± 0.62%, respectively.
X-ray diffraction analysis confirmed the formation of disordered structures in the inner core of the
vesicles. Moreover, Cur@TES system demonstrated better stability and deformability compared to
the curcumin-loaded ethosomes (Cur@ES). In-vitro transdermal experiments demonstrated that
Cur@TES significantly increased the amount of drug retained in the skin (P＜0.05). Fluorescence
imaging confirmed that the skin distribution were distinctly enhanced with the delivery by TPGS
mediated transethosomes. In addition, Cur@TES showed a significant inhibitory effect on Inflammatory
swelling in the mouse ear-swelling model.

Conclusion:
TPGS-mediated transethosomes exhibit significant transdermal advantages and enhanced
anti-inflammatory effects, providing a new perspective for the transdermal delivery of curcumin.
Deubiquitylase USP31 Induces Autophagy and Promotes the Progression
in Lung Squamous Cell Carcinoma Cells by Stabilizing E2F1 Expression
Authors: Liang Wenjun , Yang Mingxia , Wang Xiaohua , Qian Yan , Gao Ruichen , Shi Yujia , Shi Xuejun , Shi Lei , Xu Ting , Zhang Qian 
Published: January 2024

Background:
Autophagy exerts a vital role in the progression of lung squamous cell
carcinoma (LUSC). Ubiquitin-specific peptidase 31 (USP31) has recently been found to be involved
in the development of a variety of cancers. However, whether USP31 modulates autophagy
in LUSC remains unclear.

Methods:
This study revealed that high levels of USP31 were discovered in LUSC tissue samples
employing the Gene Expression Profiling Interactive Analysis (GEPIA) database, quantitative real-
time PCR (qRT-PCR), and Western blot analysis. Cell proliferation was tested via cell counting
kit 8 (CCK-8) as well as colony formation, demonstrating that USP31-stable knockdown reduced
cell viability.

Results:
Immunofluorescence analysis illustrated that USP31 knockdown blocked the occurrence
of LUSC autophagy. Meanwhile, USP31 has been shown to stabilize the expression of E2F transcription
factor 1 (E2F1) through the proteasome pathway. Furthermore, overexpressed E2F1 effectively
eliminated the effect of USP31 knockdown on LUSC cell proliferation and autophagy.

Conclusion:
In summary, this investigation proved that USP31 promoted LUSC cell growth and
autophagy, at least in part by stabilizing E2F1 expression, which provided a potential therapeutic
gene for the treatment of LUSC.
A Retrospective Analysis of the Computed Tomography Findings and Diagnosis
of 53 Cases of Elastofibroma in the Infrascapular Region
Authors: Wang Jian-wu , Peng Ru-chen 
Published: January 2024

Objective:
In this work, we have used histopathology as the gold standard for the diagnosis, calculated the sensitivity and positive predictive value (PPV) of
computed tomography (CT), and analyzed the CT and clinical characteristics of pathologically proven elastofibromas.

Methods:
A systematic retrospective analysis was performed on all patients with infrascapular lesions who were treated in the hospital from 2006 to 2018.
CT and histopathological examinations were performed for all cases, and the CT sensitivity and PPV for the diagnosis of elastofibroma were
calculated. 12 of 53 cases (20 lesions) underwent enhanced CT scan after CT plain scan, and the related clinical and CT features of elastofibromas
have been discussed

Results:
Of the 54 patients treated during the study, CT diagnosis was consistent with histopathology in 53 cases. One was a false-positive patient. The PPV
and sensitivity of the CT in the diagnosis of elastofibroma were 93.3% (95% CI 68.0%-99.8%) and 100%, respectively. The CT values of 12
patients with 20 lesions on plain and enhanced scans were statistically significant (P=0.001). The prevalence of elastofibromas in males and
females was statistically significant (P=.000). There was no statistically significant difference in the incidence of left and right elastofibromas
(P=0.752). There was no significant difference in the volume of left and right lesions (P=0.209) and the volume of elastofibromas between males
and females (P=.474).

Conclusion:
CT is the most practical tool for the evaluation of elastofibromas in the infrascapular region
A Systematic Study of Pyracantha crenulata Phytoconstituents for their
Anti-Diabetic Activity Using Computational Techniques
Authors: Arya Girish Chandra 
Published: January 2024

Background:
Diabetes mellitus is a significant medical condition with rising incidence
and fatality rates. According to WHO, around 422 million individuals globally have diabetes, the
majority of whom live in low and middle-income economies. Diabetes is entirely responsible for 1.5
million fatalities yearly. Researchers are concentrating on plant derivatives due to the higher toxicity
of conventional allopathic medicines. Antidiabetic agents and other medications, including from
plants, are significant. Pyracantha crenulata is a significant plant recognized for its various therapeutic
applications. It contains many phytoconstituents that give antidiabetic efficiency. In order to
investigate the antidiabetic efficacy of Pyracantha crenulata phytoconstituents, a study was conducted
using PDB IDs IUOK. The research was focused on the analysis of molecular docking and ADME
and toxicity studies.

Objective:
This study aimed to propose a mechanism for the antidiabetic activity of Pyracantha
crenulata phytoconstituents based on molecular docking studies.

Method:
The phytoconstituents of Pyracantha crenulata were docked using the PyRx Virtual
Screening software, and the ADME study was evaluated.

Results:
The results of molecular docking showed that many phytocosntituents of Pyracantha crenulata
have higher dock scores against antidiabetic action than conventional drugs.

Conclusion:
Based on molecular docking study, different chemical constituents may act as potent
inhibitors of diabetic proteins IUOK. By using the outcome of the research, new anti-diabetic medications
could be designed.
Bioinformatics-based Study on the Effects of Umbilical Cord Mesenchymal Stem Cells on the Aging Retina
Authors: Shi Ya-Hui , Li Jun-Qi , Min-Xu  , Wang Yu-Ying , Wang Ting-Hua , Zuo Zhong-Fu , Liu Xue-Zheng 
Published: January 2024

Background:
Retinal aging is one of the common public health problems caused by
population aging and has become an important cause of acquired vision loss in adults. The aim of
this study was to determine the role of human umbilical cord mesenchymal stem cells (hUCMSCs)
in delaying retinal ganglion cell (RGC) aging and part of the network of molecular mechanisms
involved.

Methods:
A retinal ganglion cell senescence model was established in vitro and treated with
UCMSC. Successful establishment of the senescence system was demonstrated using β-
galactosidase staining. The ameliorative effect of MSC on senescence was demonstrated using
CCK8 cell viability and Annexin V-PI apoptosis staining. The relevant targets of RGC, MSC, and
senescence were mainly obtained by searching the GeneCards database. The protein interaction
network among the relevant targets was constructed using the String database and Cytoscape, and
10 key target genes were calculated based on the MCC algorithm, based on which Gene ontologies
(GO) enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were
performed. Changes in relevant target genes were detected using real-time fluorescence quantitative
PCR and the mechanism of action of UCMSC was determined by RNA interference.

Results:
β-galactosidase staining showed that UCMSC significantly reduced the positive results of
RGC. The retinal aging process was alleviated. The bioinformatics screen yielded 201 shared
genes. 10 key genes were selected by the MCC algorithm, including vascular endothelial growth
factor A (VEGFA), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), albumin (ALB), interleukin-
6 (IL6), tumor necrosis factor (TNF), tumor protein P53 (TP53), insulin (INS), matrix metalloproteinase
9 (MMP9), epidermal growth factor (EGF), interleukin-1β (IL1B), and enrichment
to related transferase activity and kinase activity regulated biological processes involved in oxidative
stress and inflammation related pathways. In addition, PCR results showed that all the above
molecules were altered in expression after UCMSC involvement.

Conclusion:
This experiment demonstrated the role of UCMSC in delaying retinal ganglion cell
senescence and further elucidated that UCMSC may be associated with the activation of VEGFA,
TP53, ALB, GAPDH, IL6, IL1B, MMP9 genes and the inhibition of INS, EGF, and TNF in delaying
retinal senescence.
Enhancing the Regenerative Potential of Adipose-Derived Mesenchymal Stem Cells Through TLR4-Mediated Signaling
Authors: Kaçaroğlu Demet , Yaylacı Seher 
Published: January 2024

Introduction:
Toll-like receptor 4 (TLR4) is a receptor that traditionally plays an important
role in immunomodulation (regulation of the immune system) and the initiation of proinflammatory
responses. TLR4 is used in the body to recognize molecular patterns of pathogens or
damaged cells from outside. However, in recent years, it has also become clear that TLR4 can affect
the immune system and the function of stem cells, especially mesenchymal stem cells. Therefore,
understanding how TLR4 signaling works at the cellular and molecular level and using this
knowledge in regenerative medicine could be potentially useful, especially in the treatment of adipose-
derived mesenchymal stem cells (ADMSCs). How these cells can use TLR4 signaling when
used to increase their regenerative potential and repair tissues is an area of research.

Aims:
This study aims to elucidate the multifaceted role of TLR4-mediated signaling in ADMSCs.

Methods:
Employing a comprehensive set of assays, including MTT for cell viability, flow cytometry
for surface marker expression, and gene expression analysis, we demonstrate that TLR4
activation significantly modulates key aspects of ADMSC biology. Specifically, TLR4 signaling
was found to regulate ADMSCs proliferation, surface marker expression, and regenerative capacity
in a dose- and time-dependent manner. Furthermore, TLR4 activation conferred cytoprotective
effects against Doxorubicin (DOX)-induced cellular apoptosis.

Results:
These findings suggest that TLR4 signaling could be used to enhance the regenerative
abilities of ADMSCs and enable ADMSC-based therapies to be used more effectively for tissue
engineering and therapeutic purposes.

Conclusion:
However, it is important to note that research in this area needs more details and clinical
studies.
Comprehensive Bioinformatic Analysis Reveals an Autophagy-related Gene Signature for Predicting Outcome, Immune Status, and Drug
Sensitivity in Hepatocellular Carcinoma
Authors: Liu Peng , Zhou Yan , Zeng Shun , Chen Xiangjuan 
Published: January 2024

Background:
Hepatocellular carcinoma (HCC) is one of the most common malignancies
in the world, but molecular complexity and tumor heterogeneity make predictive models
for HCC prognosis ineffective. Many recent studies have suggested that autophagy is important
in tumor progression. Using autophagy-related genes (ARGs), we attempted to create a
novel signature for individual prognosis prediction in patients with HCC.

Methods:
Differentially expressed ARGs (DE-ARGs) in HCC and normal samples were
screened using TCGA datasets. Univariate Cox and multivariate Cox regression analyses were
performed to determine ARGs related to survival in HCC. An autophagy-based signature was
constructed using LASSO, and its correlation with the prognosis and the immune infiltration of
HCC patients was explored.

Results:
In this study, we screened 32 survival-related DE-ARGs by analyzing TCGA datasets.
Functional enrichment indicated that the 32 DE-ARGs may play important functional and regulatory
roles in cellular autophagy, the regulation of multiple signaling pathways, as well as in
the context of cancer and neurological diseases. Based on PPI Network, we identified several
hub genes. LASSO Cox regression analysis selected five genes (CASP8, FOXO1, PRKCD,
SPHK1, and SQSTM1) for a novel prognostic model. AUCs of 0.752, 0.686, and 0.665 in the
TCGA whole set indicated that the model accurately predicted 1-, 3-, and 5-year overall survival,
respectively. Cox regression analysis showed that the five-gene signature is an independent
and robust predictor in patients with HCC. The high-risk group demonstrated higher levels of
immune cell infiltration and exhibited a strong correlation with the immune microenvironment
and tumor stem cells. In addition, we further identified PRKCD and SQSTM1 as critical regulators
involved in HCC progression. The expression levels of PRKCD and SQSTM1 genes play a
crucial role in chemotherapy drug sensitivity and resistance.

Conclusion:
We introduce here a novel ARG-based predictive feature for HCC patients. Effective
use of this signature will aid in determining a patient's prognosis and may lead to novel approaches
to clinical decision-making and therapy.
Mairin from Huangqi Decoction Mitigates Liver Cirrhosis through
Suppression of Pro-inflammatory Signaling Pathways: A Network
Pharmacology and Experimental Study
Authors: Meng Di , Ren Shuang 
Published: January 2024

Background::
Liver cirrhosis is a consequence of various chronic liver conditions and may
lead to liver failure and cancer. Huangqi Decoction (HQD) is a Traditional Chinese Medicine (TCM)
effective for treating liver conditions, including cirrhosis. Therefore, both the active ingredients and
the pharmacological actions of HQD deserve further exploration. The active components and pharmacological
actions of HQD in preventing and treating liver cirrhosis were investigated using network
pharmacology. The actions of the principal active ingredient, Mairin, were investigated empirically.

Methods::
Using network pharmacology, the critical components of HQD were identified from multiple
databases, and UPLC screening and targets were investigated using Swiss Target Prediction.
Targets associated with liver cirrhosis were identified using the GeneCards database. GO and KEGG
enrichment analysis of targets that overlapped between HQD and cirrhosis were analyzed in DAVID,
and a “component-target-pathway” network for HQD was created in Cytoscape 3.7.2. The biological
functions of the key active component, Mairin, were investigated using in silico docking, cell experiments,
and evaluation in a carbon-tetrachloride (CCl4)-induced mouse model of liver cirrhosis.
CCK-8 and F-actin assays were used to measure cell viability and hepatic stellate cell (HSC) activation,
respectively; fibrosis was measured by histological and immunohistochemical evaluations, and
the levels of the cirrhosis-related protein α-SMA and predicted essential target proteins in the PI3KAKT,
NFκB-IκBα, and NLRP3-IL18 pathways were determined by western blotting.

Results::
Fourteen active HQD components, 72 targets, and 10 pathways common to HQD and cirrhosis
were identified. Network analysis indicated the association of Mairin with most targets and
with inflammation through the PI3K/Akt, NF-κB, and NLRP3 pathways. Dose-dependent reductions
in the activation and proliferation of LX-2 cells after Mairin treatment were observed. Mairin reversed
the histopathological changes in the livers of cirrhosis model mice. Mairin also significantly
reduced the α-SMA, NF-κB, IκBα, NLRP3, and IL-18 protein levels while increasing those of p-
PI3K and p-Akt, suggesting that Mairin mitigates liver cirrhosis through modulation of the PI3KAKT,
NFκB-IκBα, and NLRP3-IL18 pathways.

Conclusions::
Using a comprehensive investigative process involving network pharmacology, bioinformatics,
and experimental verification, it was found that Mairin, an active component of HQD,
may be useful for developing specific treatments for preventing and treating liver cirrhosis.
Current Status of Potential Antiviral Drugs Derived from Plant, Marine,
and Microbial Sources
Authors: Saini Rashmi , Ali Mohammad I. , Pant Maya , Warghane Ashish 
Published: January 2024

Abstract:
Natural substances have been the principal source of medications since antiquity.
Natural goods are gaining popularity as a source of novel medications. This article investigates a variety of variables like plant, marine, and microbial sources that contribute to the
growing interest in natural goods as a source of novel medications. Viruses have remained
resistant to treatment and prevention for a longer period than other forms of life. Viral diseases can currently only be treated with a limited number of drugs. Significant research initiatives have been committed to identifying novel antiviral natural compounds to fight viruses
that harm people, plants, insects, animals, fungi, and microbes. A recent study of the prevalence and sources of antiviral medications licensed by the Food and Drug Administration
(FDA) has focused on natural products. Out of the estimated 250,000 higher plant species,
only 5 to 15 percent have been thoroughly evaluated for the existence of bioactive substances
in them, and the ability of the other species has hardly been investigated. This review aims to
offer an overview of the crucial role played by natural products in the discovery and development of novel antiviral drugs with potent antiviral activity, including phytochemicals such
as carbohydrates, coumarins, flavonoids, chromones, alkaloids, lignans, phenols, tannins,
proteins, peptides, antiviral plant extracts, other marine, and microbial sources.
Pharmacological Effects of Traditional Chinese Medicine on Central Nervous System: A Narrow Update
Authors: Yu Qingying , Liu Molin , Sun Fujun , Liu Chuanguo , Sun Peng , Zheng Feng 
Published: January 2024

Abstract:
Central nervous system (CNS) diseases seriously affect human life and health, currently,
drugs used to treat CNS diseases mainly include receptor modulators and neurotransmitter
inhibitors, which possess considerable side effects; accordingly, there is a need for efficacious
drugs for clinical therapy. Traditional Chinese Medicines (TCMs) have a wide range of
pharmacological effects on the CNS, especially as anti-CNS diseases. TCMs can enhance both
non-specific and specific immune functions. Some TCMs can improve the adaptability of the
body, enhance the body's resistance to various harmful stimuli, regulate pathological processes,
and reverse the disordered function. TCMs and their active ingredients exhibit diverse pharmacological
effects, including anti-neuritis, anti-oxidative stress regulation, and inhibition of cell
apoptosis, with mechanisms possibly related to the regulation of the CNS function and restoring
cell metabolism disorders. Based on literature from recent years, we summarize the neuroprotective
effects of TCMs from the perspective of core pathological changes in the CNS and clinical
applications. In addition, we integrated the progress of experimental research with regard to the
pharmacological effects of TCMs on CNS. Current pharmacological investigations examining
TCMs on CNS diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD), were
reviewed to provide a reference and new concepts for further developing TCMs.
Analisis Implementasi ISAK 35 Pada YPI Ulil Albab Ar-rohman Kediri
Authors: Larasati Putri , Nurdiwaty Diah , Kurniawan Andy 
Published: January 2024

Penelitian ini dilatarbelakangi dengan adanya permasalahan pendidikan yang berkualitas yang belum merata di daerah kota dan desa. Sekolah adalah suatu Lembaga yang dapat mewujudkan pendidikan yang bermutu. Yayasan Pendidikan adalah salah satu badan hukum yang dapat membantu terwujudnya pendidikan berkualitas yang merata di setiap daerah. Dalam kegiatan operasionalnya, Yayasan memperoleh sumber daya dari pemberi yang tidak mengharapkan kembali imbalan atas dana yang telah disumbangkan. Maka dari itu Yayasan perlu membuat laporan keuangan yang andal dan relevan untuk mempertanggung jawabkan dana yang telah diterima sesuai dengan Standar Akuntansi Keuangan yang berlaku. Lokasi penelitian ini terletak pada Yayasan Pendidikan Islam Ulil Albab Ar-rohman yang terletak di Jl. Patimura No. 37 Desa Sambi Kecamatan Ringinrejo Kabupaten Kediri Provinsi Jawa Timur. Penelitian ini bertujuan untuk mengetahui penerapan ISAK 35 pada Laporan Keuangan YPI Ulil Albab Ar-rohman Kediri. Metode yang digunakan dalan penelitian ini adalah kualitatif studi kasus dimana dalam hal ini peneliti terjun langsung ke lapangan untuk mengetahui secara langsung bagaimana penerapan ISAK 35 dalam laporan keuangan Yayasan. Teknik pengumpulan data yang digunakan yakni teknik menurut Miles dan Huberman. Uji keabsahan temuan menggunakan perpanjangan pengamatan dan triangulasi data. Hasil penelitian menyatakan bahwa YPI Ulil Albab Ar-rohman Kediri sama sekali belum menerapkan ISAK 35 dalam penyajian laporan keuangan Yayasan dikarenakan kendala informasi yang masuk masih sangat minim.