bluuebunny/crossref_metadata_2025_split huggingface dataset:
Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens
Authors: Ye Lihong , Wu Jiayi , Liu Zuyi , Deng Di , Bai Shasha , Yang Lei , Xuan Yao , Liu Zehao , Shi Yafei , Liu Zhongqiu , Zhang Rong , Zhao Jinlan 
Published: November 2023

Background: Early life stress (ELS) is a major risk factor for depression in adolescents. The nucleus accumbens (NAc) is a key center of the reward system, and spine remodeling in the NAc contributes to the development of depression. The Si-Ni-San formula (SNS) is a fundamental prescription for treating depression in traditional Chinese medicine. However, little is known about the effects of SNS on behavioral abnormalities and spine plasticity in the NAc induced by ELS.Purpose: This study aimed to investigate the therapeutic effect and the modulatory mechanism of SNS on abnormal behaviors and spine plasticity in the NAc caused by ELS.Methods: We utilized a model of ELS that involved maternal separation with early weaning to explore the protective effects of SNS on adolescent depression. Depressive-like behaviors were evaluated by the sucrose preference test, the tail suspension test, and the forced swimming test; anxiety-like behaviors were monitored by the open field test and the elevated plus maze. A laser scanning confocal microscope was used to analyze dendritic spine remodeling in the NAc. The activity of Rac1 was detected by pull-down and Western blot tests. Viral-mediated gene transfer of Rac1 was used to investigate its role in ELS-induced depression-like behaviors in adolescence.Results: ELS induced depression-like behaviors but not anxiety-like behaviors in adolescent mice, accompanied by an increase in stubby spine density, a decrease in mushroom spine density, and decreased Rac1 activity in the NAc. Overexpression of constitutively active Rac1 in the NAc reversed depression-related behaviors, leading to a decrease in stubby spine density and an increase in mushroom spine density. Moreover, SNS attenuated depression-like behavior in adolescent mice and counteracted the spine abnormalities in the NAc induced by ELS. Additionally, SNS increased NAc Rac1 activity, and the inhibition of Rac1 activity weakened the antidepressant effect of SNS.Conclusion: These results suggest that SNS may exert its antidepressant effects by modulating Rac1 activity and associated spine plasticity in the NAc.
Elucidating the Histone Deacetylase Gene Expression Signatures in Peripheral Blood Mononuclear Cells That Correlate Essential Cardiac Function and Aid in Classifying Coronary Artery Disease through a Logistic Regression Model
Authors: Monisha K. , Mahema S. , Chokkalingam M. , Ahmad Sheikh F. , Emran Talha Bin , Prabu Paramasivam , Ahmed Shiek S. S. J. 
Published: November 2023

A proinflammatory role of HDACs has been implicated in the pathogenesis of atherosclerosis as an emerging novel epigenetic diagnostic biomarker. However, its association with the clinical and cardiovascular function in coronary artery disease is largely unknown. The study aimed to profile the gene expression of HDAC1–11 in human peripheral blood mononuclear cells and to evaluate their influence on hematological, biochemical, and two-dimensional echocardiographic indices in CAD. The HDAC gene expression profiles were assessed in 62 angioproven CAD patients and compared with 62 healthy controls. Among the HDACs, upregulated HDACs 1,2, 4, 6, 8, 9, and 11 were upregulated, and HDAC3 was downregulated, which was significantly (p ≤ 0.05) linked with the hematological (basophils, lymphocytes, monocytes, and neutrophils), biochemical (LDL, HDL, and TGL), and echocardiographic parameters (cardiac function: biplane LVEF, GLS, MV E/A, IVRT, and PV S/D) in CAD. Furthermore, our constructed diagnostic model with the crucial HDACs establishes the most crucial HDACs in the classification of CAD from control with an excellent accuracy of 88.6%. Conclusively, our study has provided a novel perspective on the HDAC gene expression underlying cardiac function that is useful in developing molecular methods for CAD diagnosis.
La (non) réussite scolaire des « immigrés » - Où sont les différences ?
Authors: Chauveau Gérard , Rogovas-Chauveau Eliane 
Published: November 2023

Pendant des années, la logique différencialiste à l’œuvre en face des difficultés des enfants d’immigrés a surestimé le handicap linguistique et culturel ou la distance culturelle et a, du même coup, sous-évalué, sinon masqué, la grande hétérogénéité de cette catégorie d’élèves et celle des situations éducatives locales avec ses nombreuses variables.
Le temps est venu de s’intéresser à deux spécificités des élèves issus de l'immigration : ils sont plus divers que ceux des autres catégories socioculturelles ; ils vivent des situations scolaires bien plus disparates que les autres. Quand et comment allons-nous traiter ces différences-là ?
Langue(s)/langage(s), universaux, dialogue, cultures
Authors: François Frédéric 
Published: November 2023

Qu’est-ce que savoir ou ne pas savoir une langue ?
Un ensemble de notes et réflexions qui vise à éclairer sous un angle différent, avec des propositions pratiques, les questions que l’on se pose sur le langage, le dialogue et le développement de l’enfant, et les rapports entre langue et culture.
Intégration des immigrés et intégration nationale
Authors: Aron-Schnapper Dominique 
Published: November 2023

La société française voit sa capacité d'intégration s'affaiblir. Doit-elle pour autant renoncer au « modèle républicain » ?
Une réflexion synthétique sur l'intégration, celle des immigrés et celle de la nation toute entière, à partir de l'histoire de l'immigration, des évolutions actuelles et des travaux des sociologues.
La politique de la ville et l'école
Authors: Roman Joël 
Published: November 2023

L'histoire des ZEP, qui est aussi celle de leur articulation avec la politique de la ville, va de la discrimination positive à des stratégies d'excellence.
Mais l'ambivalence et la force de la demande sociale, laquelle traduit la dynamique d'une société individualiste, font de l'école le lieu de la concurrence maximale.
Les réponses à ce défi se situent dans le développement de la formation professionnelle permanente et la requalification, autour de l'école, de la notion de service public.
Integrando CSP com linguagens de programação
Authors: Pereira Amintas Victor Ramos , De Farias Adalberto Cajueiro 
Published: November 2023

CSP consiste numa linguagem de especificação que permite uma abordagem baseada em refinamento (tornando um modelo abstrato mais concreto) e o uso de construções abstratas e expressivas para capturar diversos aspectos, representando comportamentos de maneira precisa. Sua popularidade se deve a possibilidade de executar as especificações diretamente, ao invés de se estabelecer um mapeamento para outra linguagem. Apesar de estarem disponíveis ferramentas para CSP, a dificuldade de utilizá-las, seja na escrita ou na apresentação de relações, somada a uma crescente demanda, fez surgir a necessidade de investigar o mapear desta notação para linguagem Go ou framework AKKA, bem como de ser implementada uma ferramenta que não apenas agregue funcionalidades como manipulação e compreensão textual e gráfica da linguagem, mas que também o faça de maneira mais prática e didática.
Incidência de Streptococcus Agalactiae em gestantes e neonatal uma revisão bibliográfica
Authors: De Faria Caroline Alves Pequeno , Alves Caroline Santos , Da Silva Rafaela de Oliveira , Da Conceição Sheila Cristina Faria , De Oliveira Junior Manoel Carneiro 
Published: November 2023

A bactéria Streptococcus do Grupo B (EGB), também conhecida como Streptococcus agalaciae é responsável por infecções em mulheres gestantes. São consideradas de alto risco de transmissão para o neonato no momento do parto, podendo levar ao óbito quando acompanhada de outras complicações. O objetivo do trabalho consistiu em apresentar uma revisão bibliográfica sobre Streptococcus do Grupo B (Streptococcus agalactiae) em gestantes e neonato. As publicações científicas foram selecionadas em bases de dados acessadas por meio das Bibliotecas Virtuais na área de Ciência da Saúde (destacando PubMed, Biblioteca Virtual em Saúde, BVS) e também Scielo e Google Acadêmico, empregando os seguintes descritores em português/inglês: Streptococcus do Grupo B; Streptococcus agalactiae; gestantes.
Attitudes of Political Science Instructors at Jordanian Universities towards Activating Political Involvement: An Analytical Study
Authors: Abu Shari'ah Hamzeh Ismail Ibrahim 
Published: November 2023

Objectives: The study aimed at recognizing trends of political science professors at the Jordanian universities towards the activation of political participation and recognizing the impacts of variables: (social type, age, social status academic rank, monthly income, and the university).
Methods: To meet study goals, a descriptive survey method was utilized, employing a questionnaire with two sections: one on demographic traits and the other on political science professors' perspectives regarding political participation activation in Jordanian universities. The sample included (83) professors—(59) male and (23) female—from various public and private universities.
Results: These findings address the study's questions and validate its hypotheses. Key outcomes include: fostering trust between the populace and ruling elite, ensuring peaceful power succession through fair elections, guaranteeing public freedoms, and respecting human rights as major political trends. In terms of economics, notable trends include enhancing citizens' quality of life, safeguarding the national economy, creating job opportunities, and curbing unemployment. Social priorities involve protecting the family structure, promoting diverse opinions, and combating crime and drug proliferation. Cultural and educational highlights comprise elevating education standards, reducing nepotism, favoritism, and enhancing the role of educational institutions.
Conclusions: The study submitted several recommendations aiming at activating political participation, the most important of which are: laying dialogue programs about activating political participation to grant space for alighting discussion to increase political awareness level for the significance of political participation and reviewing rules and legislations that hinder this participation.
Simulasi Pengaruh Diameter Roda 660 mm, 774 mm dan 860 mm Serta Variasi Kecepatan Terhadap Kriteria Nadal dan Ride Index Lintas R80 LRT Palembang
Authors: Utomo Ilham , Atmaja Dadang Sanjaya , Pratama Gilar Tantra 
Published: November 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan diameter roda kereta terhadap ride index dan kriteria nadal pada berbagai kecepatan. Metode analisis menggunakan simulasi Longitudinal Train Dynamic Universal Mechanism 9.0. Variasi diameter roda yang digunakan dengan menggunakan 3 jenis diameter yang berbeda. Sedangkan variasi kecepatan yang digunakan mulai dari 15 km/jam hingga kereta mengalami anjlok. Standar yang digunakan dalam simulasi yakni indeks sperling standar ISO 2631. Hasil dari simulasi didapatkan bahwa roda dengan diameter lebih kecil lebih baik dalam melewati lengkung R80. Hal tersebut dibuktikan pada kecepatan 15 km/jam diameter 660 mm menghasilkan nilai ride index horizontal dan vertikal sebesar 1,2078 dan 1,1282, diameter 774 mm sebesar 1,8306 dan 1,7078, diameter 860 mm sebesar 1,8293 dan 1,7068, sehingga terjadi peningkatan sampai dengan kecepatan tertinggi yaitu 60 km/jam pada diameter 660 mm menghasilkan nilai ride index horizontal dan vertikal sebesar 2,2744 dan 2,1140, pada diameter 774 mm sebesar 2,2751 dan 2,1140, pada diameter 860 mm sebesar 2,2762 dan 2,1162, sehingga dengan bertambah besarnya diameter roda, maka nilai ride index akan semakin besar.
“Once upon a time there was a desperately happy jew”: or how to explain the Holocaust to children (André Schwarz‑Bart)
Authors: Gyssels Kathleen 
Published: November 2023

Kathleen Gyssels onderzoekt de paradox dat in de roman die als ‘volwassen’ wordt aangestipt, het kind toch centraal staat: enerzijds door de jonge leeftijd van het hoofdpersonage dat wordt geconfronteerd met de opkomst van het nazisme; daarnaast door het ‘geloof’ in verhalen en sprookjes, wanneer hij als gulzige ‘zondagse’ Jood sprookjes verslindt (‘Er was eens’); en ten slotte door de impact van beelden op een ogenblik dat de taal nog in ‘opbouw’ is. Gedurende zijn hele schrijverscarrière ondernam André Schwarz-Bart talrijke pogingen om kinderen over de Shoah te vertellen.
Work environment development using cognitive work analysis’ decision ladders.
Authors: Suleiman Abdulqadir Mohamad 
Published: November 2023

The study aimed to create decision-making content for workplace work environment development, followed by a limited evaluation to determine the perception of the importance of the identified content in different sectors. Enforcement/administrative orders in workplace inspection reports were used as empirical infor-mation on workplaces. This information was used to design decision ladders, which form the second phase of cognitive work analysis, the activity analysis. The decision ladders, which support decision-making, cov-ered work functions identified in an earlier work domain analysis study, i.e., exposure prevention, organisa-tional management, competence realisation, workers’ empowerment, psychosocial work environment man-agement, and administration. Specified content of decision ladders for each function was used to prepare a questionnaire for evaluating the content validity for work environment development.
Altogether, 29 items were identified as the content for work environment development. Statistical analysis of the limited evaluation showed no significant difference between the different sectors in their perceptions of the importance of the content in developing work environments. Similar sectoral perceptions' trends support the content utility and validity in work environment development.
The procedure formulation step of the decision ladders, with the phrase “What steps are needed to...” applied preceding the identified content constructs, provides practical activities regarded as essential for work environment development.
Using enforcement inspection reports as the basis for work environment development is a novel approach to addressing workplace safety and health management challenges. Further, the universal utility of the content allows for its implementation across sectors, allowing for workplace-specific decision-making on management measures.
The 'master's dissertation fair': reflections on impact and future development
Authors: Koromila Georgia , Hood Sonia 
Published: November 2023

Every year in early spring, postgraduate taught (PGT) students start preparing for their dissertation project. At the University of Reading, this time coincides with the end of teaching, including the Library seminars supporting skills development. Acknowledging that our sessions were ill-timed to support effectively our PGT students at a challenging stage in their degree trajectory, the Study Advice and Academic Liaison teams at the University of Reading Library trialled in June 2020 a week of webinars tailored to PGT level and focusing on elements of the dissertation. The Master’s Dissertation Fair was born! The popularity and positive reception of the initiative took us by surprise and motivated us to continue running the Master’s Dissertation Fair as an annual tradition ever since.
In this session, we shared our reflections on the successes and lessons learnt from the first three iterations of this programme, focusing on its Study Advice component. We reviewed the student feedback collected post session and explored what the impact was on our one-to-one service in supporting PGT students with dissertation projects over the summer. We also discussed how this initiative impacted our team, as it provided a (rare for us) opportunity to plan and develop collaboratively a coherent and complementary set of sessions. Finally, we explored how this reflection on impact can inform our planning for a more holistic approach to PGT support. For example, are there opportunities to use new formats beyond the webinar? What else could we do to improve our reach and inclusivity?
Apps in LD: gifts or gimmicks?
Authors: West Amy 
Published: November 2023

In ‘one-shot’ Learning Development (LD) teaching, how much space is there for using apps (and similar technologies) creatively? Can they further students’ understanding and enable active learning within workshops; is there even potential for using them in tutorials? What barriers are there to their use, how could we remove these, and indeed should we – is there enough to be gained or are they just a gimmick?

This Wild Card session was an opportunity to collaboratively explore the potential of a selection of apps and technologies which are used in other areas of education, and consider whether they can augment provision in LD. The apps and programmes chosen for this session were used in an international Erasmus+ research project, which worked with lecturers, teachers, students, and school children who observed their strengths and limitations in use (Digital Learning Across Boundaries: Developing Changemakers (DLAB), 2017-2022). This Wild Card session looked to evaluate how these apps might be applied in the LD world by reviewing benefits and barriers to their use in an LD context, and considering how we might maximise any usefulness and contend with limitations or concerns. I wanted to explore how they might support transition through familiarity and links with previous education experiences, and whether the activities which use them might impact on belonging. Participants were encouraged to evaluate and share their thoughts on the apps, and collectively generate a resource of ideas as to their use in LD. This resource could then be shared and drawn on by others.
Evaluation of clopidogrel use on gastric precancerous lesions: Does it have chemopreventive effect?
Authors: AKYOL Taner 
Published: November 2023

Aims: Gastric malignancies are the third most common cause of cancer-related deaths. Although aspirin and clopidogrel have been reported to reduce the risk of colorectal cancer, their effects on gastric cancer are still under investigation. In this study, we aimed to determine whether clopidogrel has an effect on the development of gastric precancerous lesions.
Methods: The study was designed as a retrospective case-control study. The study was conducted between January 2021 and April 2023 in the Gastroenterology Clinic of Samsun University Samsun Training and Research Hospital. Patients who underwent upper GIS endoscopy and biopsy examination due to dyspeptic complaints were scanned from the electronic data system of the hospital and their data were recorded by forming 4 groups as clopidogrel (89 patients), low-dose aspirin (ASA) (172 patients), non-aspirin non-steroidal anti-inflammatory drug (NA-NSAID) users (110 patients) and control group without antiplatelet use (110 patients). Statistical analyses were accomplished with SPSS for Windows v20.0.
Results: Mean duration of drug use was 2 years for clopidogrel, 1.47 years for ASA and 0.35 years for NA-NSAID. The incidence of peptic ulcer was 7.2% in the control group, 38%, 15.1%, 49% in clopidogrel, ASA, NA-NSAID users, respectively (p
SEMÁNTICA DE LOS EXPERIMENTOS (MENTALES) DE GRAVEDAD DE GALILEO
Authors: Hertogh C. P. 
Published: November 2023

Los TE de los cuerpos en caída aparecen en el Diálogo sobre los Dos Nuevos Principios de 1638, y recientemente han sido actualizados por el experimento del martillo y la pluma de la misión Apollo 15, una prueba de caída realizada en la superficie de la luna (Scott, 1971). En la literatura reciente sobre TE se destaca que durante mucho tiempo se les ha considerado erróneamente como un experimento real (Galileo lanzando dos objetos desde la Torre de Pisa), y que actualmente se analizan como un TE antagónico a Aristóteles, de cuerpos compuestos o atados (Gendler, 1996/2000; Brown, 1991a, 1991b; Sorensen, 1992; Brown & Fehige, 2019).

En los análisis lógicos profundos mostramos, con la ayuda de la lógica matemática de predicados, que (1) la teoría transitiva aristotélica de la caída es reemplazada por la teoría galileana, más simple, de la gravedad simétrica (ya que en el segundo caso, todos los objetos caen independientemente de sus masas con la misma velocidad relativa a la constante de gravedad del cuerpo celeste bajo investigación) y (2) que, de acuerdo con, por ejemplo, las suposiciones carnapianas, los protocolos inductivos y deductivos pueden considerarse complementarios, es decir, traducibles entre sí, lo que puede explicar cómo los TE de ensayo y error pueden interpretarse como experimentos Ideales.
ANALYSIS OF THE QUALITY OF THE WEBSITE OF THE IMMIGRATION OFFICE CLASS I TPI YOGYAKARTA ON THE SATISFACTION OF ITS USERS WITH THE PIECES METHOD
Authors: Nursanto Gunawan Ari , Boy Hertantyo Galuh , Dhimas Agung R. Yohanes 
Published: November 2023

Abstract
This research aims to find out the quality of the website of TPI Yogyakarta's Class I Immigration Office whether it has been following the standardization of web pages that have been determined by the Ministry of Law and Human Rights through descriptive analysis and further to find out the quality of the website with the PIECES method consisting of performance, information, economy, control, efficiency, and service to website user satisfaction. This research was conducted with a mixed-method approach that convergent parallel design. The first stage of research is carried out with a qualitative approach that is descriptive analysis and the second stage uses a quantitative approach. Qualitative data collection is carried out by observing the appearance of work and the actual state of the website. Quantitative data collection was carried out by distributing questionnaires to 100 respondents. The results of research on website standardization show that four things have not been following the standardization that has been determined. Based on research on the influence of PIECES variables on website user satisfaction, it was found that there were simultaneous influences of PIECES variables and there were three variables that partially affect user satisfaction, namely performance, information, and efficiency, and dominated by efficiency variables.