bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karahan-99 × BW3 Ekmeklik Buğday Popülasyonu F4 Bireylerinin Allelik Varyasyonunun DNA Markörleri ile Belirlenmesi
Authors: YÜCE İlker , TOPSAKAL Münire , TEKİN Ali , ÇÖKEN TEKİN İmren , DEMİREZEN Ayşe Nur , ŞENAY Ali , KORUCU Burakhan , KORKMAZ Ali , GÜNGÖR Hüseyin , AYDOĞDU İlker , DUMLUPINAR Ziya 
Published: December 2023

Buğday insanoğlunun yerleşik hayata geçtiğinden beri en çok kullandığı temel besin maddesidir. Bitki ıslahçıları, artan Dünya nüfusuna paralel olarak buğday bitkisinde de verimi artırmak için çok büyük gayretler ortaya koymaktadırlar. Bu çalışmada Karahan-99 ekmeklik buğday çeşidi ile BW3 buğday genotipinin melezlenmesi sonucu elde edilen 22 F4 hattı bazı özellikler ile ilişkili olduğu bilinen 11 fonksiyonel DNA markörü ile karakterize edilmiştir.
Araştırmada kullanılan 11 markörden 7 tanesi (Xgwm18, Xwgp118, Xgwm131, Xgwm47, Sun479, Sun209 ve UHW89) Karahan-99 × BW3 ekmeklik buğday popülasyonunda polimorfik bant üretmiştir. En fazla allel sayısı Sun479 marköründen (18 adet) elde edilirken, en az bant sayısı da UHW89 ve Xgwm131 (1 adet) markörlerinden elde edilmiştir. Ortalama allel sayısı 6.71 olurken, ortalama polimorfizm bilgi içeriği 0.99 olarak tespit edilmiştir. Xgwm131 markörü Karahan-99_M6_72-10/BW3_F4_10 genotipinde Yr39 sarı pas geni ile ilişkili allele sahip olurken, Xgwm18 markörü Karahan-99_M6_72-10/BW3_F4_22 genotipinde Yr26 sarı pas dayanıklılık geni ile ilişkili beklenen uzunlukta bant vermiştir.
Dimensi Store Atmosphere Pada Keputusan Pembelian Konsumen Rumah Makan Tahta Makarim Jombang
Authors: Muhyidin Muhammad Fahmi , Santoso Rohmad Prio 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui variabel-variabel yang mempengaruhi keputusan pembelian. Yaitu dengan meneliti dimensi dari store athmosphere yang terdiri dari 4 variabel yaitu Exterior , General Interior, Store Layout dan interior display pada rumah makan Tahta Makarim Jombang. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan menyebar angket pada 50 orang pengunjung di rumah makan Tahta Makarim Jombang dengan metode teknik sampling insidental. Analisis yang digunakan dalam penelitian ini adalah analisa regresi linier berganda. Hasil penelitian ini menunjukkan bahwa (1) Tingkat Exterior , General Interior, Store Layout dan interior display berpengaruh secara parsial terhadap keputusan pembelian pada rumah makan Tahta Makarim Jombang dengan nilai signifikan dan positif (2) Tingkat dimensi Store Atmosphere berpengaruh secara simultan terhadap keputusan pembelian pada rumah makan Tahta Makarim Jombang dengan nilai signifikan dan positif.
Pengaruh Gaya Kepemimpinan, Kompensasi, dan Disiplin Kerja Terhadap Kinerja Karyawan Pada UD. Mekar Jaya
Authors: Triadmojo Cahyo , Mahfudiyanto  
Published: December 2023

Penelitian ini guna mengetahui bagaimana Pengaruh Gaya Kepemimpinan, Kompensasi, dan Disiplin Kerja terhadap Kinerja Karyawan pada UD. Mekar Jaya. Pada kegiatan penelitian ini dilangsungkan dengan meminta karyawan yang bekerja di UD. Mekar Jaya sebagai responden penelitian. Metode yang digunakan adalah dengan menggunakan metode penelitian kuantitatif dan menggunakan pendekatan kausalitas. Sampel dalam peneilitan ini adalah sejumlah 47 responden. Hasil penelitian menunjukkan Berdasarkan hasil uji F terdapat Fhitung untuk ketiga nilai variabel tersebut adalah 4.139 yang mana ketiga nilai dari variabel yang diteliti tersebut adalah lebih besar dari Ftabel yaitu 2,81 dengan demikian H0 ditolak dan Ha diterima. Dari hasil uji T didapat thitung untuk X1 sebesar 0.107, untuk X2 sebesar 0.001 dan untuk X3 sebesar 0.310. Dengan itu kesimpulannya ialah bahwa H0 ditolak dan Ha diterima.
Pengaruh DER, TATO, dan Firm Size terhadap ROA pada PT Elnusa Tbk Periode 2011 - 2021
Authors: Dewi Iriana Kusuma , Budhiarjo Intan Sari 
Published: December 2023

The aim of the research is to determine and analyze the influence of Debt to Equity Ratio (DER), Total Asset Turnover (TATO) and Firm Size on Return on Assets (ROA) at PT Elnusa Tbk for the 2011-2021 period. The population in this research is all financial reports of PT Elnusa Tbk, while the sample used is the profit/loss report and consolidated financial position of PT Elnusa Tbk for the 2011-2021 period. The research results obtained an Fcount value of 67.357 > Ftable 4.35, which means that DER, TATO and Firm Size simultaneously had a significant effect on ROA at PT Elnusa, while partially DER on ROA was obtained tcount -4.201 > ttable 2.30600 which means DER has a significant effect on ROA. TATO on ROA obtained tcount 8.873 > ttable 2.30600 where ROA has a significant effect on ROA while Firm Size on ROA obtained tcount -1.114 < ttable 2.30600 where Firm Size does not have a significant effect on ROA. The conclusion obtained based on research is that partially DER on ROA has a significant influence because the capital owned by the company can cover debts from external parties, as well as TATO on ROA which has a significant influence, which means that management is able to manage all investments to generate sales, etc. This is the case with Firm Size on ROA which does not have a significant effect, this is because Firm Size only looks at how big the company is in producing products.
Abstrak
Tujuan penelitian adalah untuk mengetahui dan menganalisis pengaruh Debt to Equity Ratio (DER), Total Asset Turnover (TATO) dan Firm Size Terhadap Return on Asset (ROA) pada PT Elnusa Tbk Periode Tahun 2011-2021. Populasi dalam penelitian ini adalah seluruh laporan keuangan PT Elnusa Tbk, sedangkan sampel yang digunakan adalah laporan laba/rugi dan posisi keuangan konsolidasian PT Elnusa Tbk periode 2011-2021. Hasil penelitian diperoleh nilai Fhitung 67,357 > Ftabel 4,35 yang artinya DER, TATO dan Firm Size secara simultan berpengaruh signifikan terhadap ROA pada PT Elnusa, sedangkan secara parsial DER terhadap ROA diperoleh thitung -4,201 > ttabel 2,30600 yang artinya DER berpengaruh signifikan terhadap ROA. TATO terhadap ROA diperoleh thitung 8,873 > ttabel 2,30600 dimana ROA berpengaruh signifikan terhadap ROA sedangkan Firm Size terhadap ROA diperoleh thitung -1,114 < ttabel 2,30600 di mana Firm Size tidak berpengaruh signifikan terhadap ROA. Simpulan yang diperoleh berdasarkan penelitian yakni secara parsial DER terhadap ROA mempunyai pengaruh yang signifikan dikarenakan modal yang dimiliki perusahaan dapat menutupi hutang-hutang dari pihak luar, begitu juga dengan TATO terhadap ROA yang berpengaruh signifikan yang artinya manajemen mampu mengelola seluruh investasi guna menghasilkan penjualan, lain halnya dengan Firm Size terhadap ROA yang tidak berpengaruh signifikan, hal ini dikarenakan Firm Size hanya melihat seberapa besar ukuran perusahaan dalam menghasilkan produk.
Kata Kunci: DER, TATO, Firm Size, ROA
Influence of Work-Family Conflict, Workload, and Work Pressure as Mediating Variables on the Performance of Female Employees
Authors: Linda Arnova , Rino Rino 
Published: December 2023

Purpose – The main purpose of this study was to assess how Work-Family conflict, workload, and work stress function as mediating factors influencing the performance of female employees at BPS (Central Bureau of Statistics) in the West Sumatra Province.
Methodology – This quantitative investigation was conducted using a survey approach, with the sample consisting of 188 married or formerly married female employees out of a total of 128 participants. A questionnaire was used as an instrument which was designed using Google form and consisted of 58 questions. Furthermore, the sampling was carried out using Cluster Sampling, with districts/cities serving as the clusters. Descriptive statistical and Partial Least Square (PLS) analyses were adopted for the data analysis process using the Smart PLS 3.2.3 program.
Findings – The results showed that workload and Work-Family conflict had a positive influence on both work pressure and the performance of female employees. Meanwhile, Work-Family conflict and work pressure negatively influenced the performance of female employees. A negative influence was also observed on the performance of women employees due to Work-Family conflict, mediated through work pressure.
Originality – This research investigated the influence of Work-Family conflict and workload on the performance of women employees, mediated by job pressure.
Evaluation of the in vitro antioxidant and antitumor activity of hydroalcoholic extract from Jatropha mollissima leaves in Wistar rats
Authors: Iqbal Muhammad Omer , Gu Yuchao , Khan Imran Ahmad , Wang Ruihong , Chen Jin 
Published: December 2023

Introduction: Despite modern sciences and advancements in new drugs or chemicals, the new era now rushes natural remedies for various illnesses and diseases that lead to end organ damage. In this study, we investigated Jatropha mollissima ethanolic extract’s effect against doxorubicin-induced cardiotoxicity and renal toxicity.Methods: To determine phytochemicals, a phytochemical screening was conducted. Various assays were used to measure the antioxidant activity, including the DPPH (2,2-diphenylpicrylhydrazyl), SOD (superoxide dismutase), NO (nitric oxide), and others. The antiproliferative effect of Jm was assessed by MTT assay; morphological analysis was performed using an inverted and phase contrast microscope, ultra morphological analysis of apoptosis with acridine orange (AO)/propidium iodide (PI) staining.Results: It was seen that doxorubicin caused elevated serum markers and abnormal changes in histological patterns. The significant reduction in cardiac and renal marker levels seen in groups given either 400 or 600 mg/kg of crude extract demonstrates that Jm has a protective effect against doxorubicin-induced cardiotoxicity due to the presence of active phytoconstituents having antioxidant potential. There is a dose-dependent decrease in cell viability when using J. mollissima. Apoptosis was observed in the treated cells.Conclusion: In conclusion, our research lends credence to the idea that J. mollissima could be used for cancer management and have cardioprotective and nephroprotective effects.
Role of gut microbiota and bacterial translocation in acute intestinal injury and mortality in patients admitted in ICU for septic shock
Authors: Magnan Chloé , Lancry Thomas , Salipante Florian , Trusson Rémi , Dunyach-Remy Catherine , Roger Claire , Lefrant Jean-Yves , Massanet Pablo , Lavigne Jean-Philippe 
Published: December 2023

IntroductionSepsis is a life-threatening organ dysfunction with high mortality rate. The gut origin hypothesis of multiple organ dysfunction syndrome relates to loss of gut barrier function and the ensuing bacterial translocation. The aim of this study was to describe the evolution of gut microbiota in a cohort of septic shock patients over seven days and the potential link between gut microbiota and bacterial translocation.MethodsSixty consecutive adult patients hospitalized for septic shock in intensive care units (ICU) were prospectively enrolled. Non-inclusion criteria included patients with recent or scheduled digestive surgery, having taken laxatives, pre- or probiotic in the previous seven days, a progressive digestive neoplasia, digestive lymphoma, chronic inflammatory bowel disease, moribund patient, and pregnant and lactating patients. The primary objective was to evaluate the evolution of bacterial diversity and richness of gut microbiota during seven days in septic shock. Epidemiological, clinical and biological data were gathered over seven days. Gut microbiota was analyzed through a metagenomic approach. 100 healthy controls were selected among healthy blood donors for reference basal 16S rDNA values.ResultsSignificantly lower bacterial diversity and richness was observed in gut microbiota of patients at Day 7 compared with Day 0 (p&lt;0.01). SOFA score at Day 0, Acute Gastrointestinal Injury (AGI) local grade, septic shock origin and bacterial translocation had an impact on alpha diversity. A large increase in Enterococcus genus was observed at Day 7 with a decrease in Enterobacterales, Clostridiales, Bifidobacterium and other butyrate-producing bacteria.DiscussionThis study shows the importance of bacterial translocation during AGI in septic shock patients. This bacterial translocation decreases during hospitalization in ICUs in parallel to the decrease of microbiota diversity. This work highlights the role of gut microbiota and bacterial translocation during septic shock.
Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function
Authors: Zhang Yue-Yang , Gui Jing , Chen Bing-Xue , Wan Qin 
Published: December 2023

BackgroundThis study aimed to assess the correlation between renal function-related indices and vascular damages among patients with type 2 diabetes mellitus (T2DM) and normal renal function.MethodsWe screened a cohort of eligible patients with T2DM, ultimately including 826 individuals. Utilizing multifactorial logistic regression, we conducted an in-depth analysis to explore the potential associations between renal function-related indices—specifically BUN, Cr, ALB, ACR, and eGFR—and the incidence of diabetic vascular damage. Additionally, to comprehensively understand the relationships, we employed Spearman correlation analysis to assess the connections between these indicators and the occurrence of vascular damage.ResultsIn this cross-sectional study of 532 patients with carotid atherosclerosis (CA), the prevalence of CA was positively correlated with Cr (53.1%, 72.3%, 68.0%, P&lt;0.05) and negatively correlated with eGFR (71.6%, 68.5%, 53.1%, P&lt;0.05). the higher the Cr, the higher the predominance ratio of CA (T1: reference; T2:OR. 2.166,95%CI:1.454,3.225; T3:OR:1.677, 95%CI:1.075, 2.616; P&lt;0.05), along with an eGFR of 66.9% and 52.0% in terms of sensitivity and specificity, with a 95% CI of 0.562-0.644.ConclusionWithin our experimental sample, a noteworthy observation emerged: Creatinine (Cr) exhibited a positive correlation with the prevalence of individuals affected by carotid atherosclerosis (CA), underscoring a potential connection between Cr levels and CA incidence. Conversely, the estimated Glomerular Filtration Rate (eGFR) demonstrated a negative correlation with the occurrence of CA, implying that lower eGFR values might be associated with an increased likelihood of CA development.
Cardiorespiratory fitness as a mediator between body fat rate and executive function in college students
Authors: Zhu Lina , He Aihong , Chen Dandan , Dong Xiaoxiao , Xiong Xuan , Chen Aiguo 
Published: December 2023

PurposeTo examine whether body fat rate (BF%) is associated with cardiorespiratory fitness (CRF) and whether cardiorespiratory fitness (CRF) mediates the association between BF% and Executive function (EF) in young adults.MethodsIn this cross-sectional study, 226 college students were recruited from an university. Flanker, 2-back, and odder and shifting tasks were used to assess EF. The incremental cardiopulmonary exercise tests were performed, and maximal oxygen consumption was recorded during test. The body composition measuring instrument was used to evaluate the participants’ BF%.ResultsThe BF% of college students was negatively correlated with each EF, BF% was negatively correlated with CRF, and CRF was negatively correlated with EF (P&lt; 0.001). Structural equation modeling (SEM) and simultaneous analysis of several groups were used to construct mediator model. The CRF of college students plays a partial mediating role between BF% and EF, and the mediating effect accounts for 48.8% of the total effect value. Sex has no moderate effect on the relationship between BF%, CRF, and EF.ConclusionsCollege students with high BF% can improve their CRF by strengthening physical exercise, thereby indirectly improving their EF. Therefore, college students who have a higher body fat percentage should be compensated for engaging in physical exercise in order to enhance their CRF and mitigate the detrimental effects of obesity and overweight on EF.
Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion
Authors: Martin Carli Jayne F. , Dzieciatkowska Monika , Hernandez Teri L. , Monks Jenifer , McManaman James L. 
Published: December 2023

Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) and their associated membranes (MFGMs) contain the majority of milk lipids and many bioactive components that contribute to neonatal development and health, yet their compositions have not been fully defined, and the mechanisms responsible for formation of these structures remain incompletely understood.Methods: In this study, we used untargeted mass spectrometry to quantitatively profile the protein compositions of freshly obtained MFGs and their paired, physically separated MFGM fractions from 13 human milk samples. We also quantitatively profiled the MFG protein compositions of 9 pooled milk samples from 18 lactating mouse dams.Results: We identified 2,453 proteins and 2,795 proteins in the majority of human MFG and MFGM samples, respectively, and 1,577 proteins in mouse MFGs. Using paired analyses of protein abundance in MFGMs compared to MFGs (MFGM-MFG; 1% FDR), we identified 699 proteins that were more highly abundant in MFGMs (MFGM-enriched), and 201 proteins that were less abundant in MFGMs (cytoplasmic). MFGM-enriched proteins comprised membrane systems (apical plasma membrane and multiple vesicular membranes) hypothesized to be responsible for lipid and protein secretion and components of membrane transport and signaling systems. Cytoplasmic proteins included ribosomal and proteasomal systems. Comparing abundance between human and mouse MFGs, we found a positive correlation (R2 = 0.44, p &lt; 0.0001) in the relative abundances of 1,279 proteins that were found in common across species.Discussion: Comparative pathway enrichment analyses between human and mouse samples reveal similarities in membrane trafficking and signaling pathways involved in milk fat secretion and identify potentially novel immunological components of MFGs. Our results advance knowledge of the composition and relative quantities of proteins in human and mouse MFGs in greater detail, provide a quantitative profile of specifically enriched human MFGM proteins, and identify core cellular systems involved in milk lipid secretion.
Neuropsychological, plasma marker, and functional connectivity changes in Alzheimer’s disease patients infected with COVID-19
Authors: Zhang Shouzi , Zhang Li , Ma Li , Wu Haiyan , Liu Lixin , He Xuelin , Gao Maolong , Li Rui 
Published: December 2023

IntroductionPatients with COVID-19 may experience various neurological conditions, including cognitive impairment, encephalitis, and stroke. This is particularly significant in individuals who already have Alzheimer’s disease (AD), as the cognitive impairments can be more pronounced in these cases. However, the extent and underlying mechanisms of cognitive impairments in COVID-19-infected AD patients have yet to be fully investigated through clinical and neurophysiological approaches.MethodsThis study included a total of 77 AD patients. Cognitive functions were assessed using neuropsychiatric scales for all participants, and plasma biomarkers of amyloid protein and tau protein were measured in a subset of 25 participants. To investigate the changes in functional brain connectivity induced by COVID-19 infection, a cross-sectional neuroimaging design was conducted involving a subset of 37 AD patients, including a control group of 18 AD participants without COVID-19 infection and a COVID-19 group consisting of 19 AD participants.ResultsFor the 77 AD patients between the stages of pre and post COVID-19 infection, there were significant differences in cognitive function and psychobehavioral symptoms on the Montreal Scale (MoCA), the neuropsychiatric inventory (NPI), the clinician’s global impression of change (CIBIC-Plus), and the activity of daily living scale (ADL). The COVID-19 infection significantly decreased the plasma biomarker level of Aβ42 and increased the plasma p-tau181 level in AD patients. The COVID-19-infected AD patients show decreased local coherence (LCOR) in the anterior middle temporal gyrus and decreased global correlation (GCOR) in the precuneus and the medial prefrontal cortex.ConclusionThe findings suggest clinical, cognitive, and neural alterations following COVID-19 infection in AD patients and emphasize the need for close monitoring of symptoms in AD patients who have had COVID-19 and further exploration of the underlying mechanisms.
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Authors: Alghusen Ibtihal M. , Carman Marisa S. , Wilkins Heather , Ephrame Sophiya John , Qiang Amy , Dias Wagner B. , Fedosyuk Halyna , Denson Aspin R. , Swerdlow Russell H. , Slawson Chad 
Published: December 2023

BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and increasing neuronal stress. Therefore, investigating the basic mechanisms of how mitochondrial homeostasis is regulated is essential. Herein, we investigate the role of O-GlcNAcylation, a single sugar post-translational modification, in controlling mitochondrial stress-induced transcription factor Activating Transcription Factor 4 (ATF4). Mitochondrial dysfunction triggers the integrated stress response (ISRmt), in which the phosphorylation of eukaryotic translation initiation factor 2α results in the translation of ATF4.MethodsWe used patient-derived induced pluripotent stem cells, a transgenic mouse model of AD, SH-SY5Y neuroblastoma and HeLa cell-lines to examine the effect of sustained O-GlcNAcase inhibition by Thiamet-G (TMG) on ISRmt using biochemical analyses.ResultsWe show that TMG elevates ATF4 protein levels upon mitochondrial stress in SH-SY5Y neuroblastoma and HeLa cell-lines. An indirect downstream target of ATF4 mitochondrial chaperone glucose-regulated protein 75 (GRP75) is significantly elevated. Interestingly, knock-down of O-GlcNAc transferase (OGT), the enzyme that adds O-GlcNAc, in SH-SY5Y increases ATF4 protein and mRNA expression. Additionally, ATF4 target gene Activating Transcription Factor 5 (ATF5) is significantly elevated at both the protein and mRNA level. Brains isolated from TMG treated mice show elevated levels of ATF4 and GRP75. Importantly, ATF4 occupancy increases at the ATF5 promoter site in brains isolated from TMG treated mice suggesting that O-GlcNAc is regulating ATF4 targeted gene expression. Interestingly, ATF4 and GRP75 are not induced in TMG treated familial Alzheimer’s Disease mice model. The same results are seen in a human in vitro model of AD.ConclusionTogether, these results indicate that in healthy conditions, O-GlcNAc regulates the ISRmt through regulating ATF4, while manipulating O-GlcNAc in AD has no effect on ISRmt.