bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury
Authors: Thompson Elizabeth J. , Zimmerman Kanecia O. , Gonzalez Daniel , Foote Henry P. , Park Sangah , Hill Kevin D. , Hurst Jillian H. , Hornik Chi D. , Chamberlain Reid C. , Gbadegesin Rasheed A. , Hornik Christoph P. 
Published: November 2023

AbstractCardiac surgery‐associated acute kidney injury (CS‐AKI) occurs in approximately 65% of neonates undergoing cardiac surgery on cardiopulmonary bypass and contributes to morbidity and mortality. Caffeine may reduce CS‐AKI by counteracting adenosine receptor upregulation after bypass, but pharmacokinetics (PK) in this population are unknown. The goal of our analysis is to address knowledge gaps in age‐, disease‐, and bypass‐related effects on caffeine disposition and explore preliminary associations between caffeine exposure and CS‐AKI using population PK modeling techniques and an opportunistic, electronic health record‐integrated trial design.We prospectively enrolled neonates receiving preoperative caffeine per standard of care and collected PK samples. We retrospectively identified neonates without caffeine exposure undergoing surgery on bypass as a control cohort. We followed US Food and Drug Administration guidance for population PK model development using NONMEM. Effects of clinical covariates on PK parameters were evaluated. We simulated perioperative exposures and used multivariable logistic regression to evaluate the association between caffeine exposure and CS‐AKI.Twenty‐seven neonates were included in model development. A 1‐compartment model with bypass time as a covariate on clearance and volume of distribution best fit the data. Twenty‐three neonates with caffeine exposure and 109 controls were included in the exposure‐response analysis. Over half of neonates developed CS‐AKI. On multivariable analysis, there were no significant differences between CS‐AKI with and without caffeine exposure. Neonates with single‐ventricle heart disease without CS‐AKI had consistently higher simulated caffeine exposures. Our results highlight areas for further study to better understand disease‐ and bypass‐specific effects on drug disposition and identify populations where caffeine may be beneficial.
Enhancing kitchen waste minimization and energy generation at 20 °C: a psychrophilic anaerobic co‐digestion study
Authors: Esparza‐Soto Mario , Alcaraz‐Ibarra Sergio , Lucero‐Chavez Mercedes , Jimenez‐Moleon Maria del Carmen , Mier‐Quiroga Miroslava de los Angeles , Fall Cheikh 
Published: November 2023

AbstractBackgroundIn developing countries, anaerobic digestion still represents an emerging technology for solid waste management, despite the great energy potential of methane in biogas for heating purposes, especially in low‐temperature regions. This research evaluated the effect of hydraulic retention time (40–120 days) on the anaerobic co‐digestion of 35% w/w waste activated sludge and 65% w/w organic kitchen waste at a low temperature (20 °C). The anaerobic co‐digestion was conducted in five 11‐L semicontinuous anaerobic digesters. Additionally, the expected energy production from organic kitchen waste was calculated.ResultsThe specific methane yield (SMY) ranged from 0.20 to 0.27 LCH4 g‐VSadd−1, comparable to the SMY reported for meso‐ and thermophilic anaerobic digestion. Moreover, the expected energy production was 1.06 MJ day−1 of equivalent liquefied petroleum gas, which could satisfy ≤6.6% of the daily water heating requirements of an average Mexican household. The hydraulic retention time in the range of 60–120 days did not seem to significantly affect the performance of the digesters.ConclusionsThese digesters could easily be installed in low temperature regions for domestic use. The waste activated sludge substrate can be replaced with other nitrogen‐rich substances for indoor use. The data shown in this research set the basis for further investigations and domestic applications. © 2023 Society of Chemical Industry (SCI).
Iron overload in hemodialysis patients: Comparison of serum iron parameters with T2* MRI sequence
Authors: Delibaş Deniz , Evrimler Şehnaz , Ercan Karabekir , Gümüş Mehmet , Sarıyıldırım Abdullah , Arslan Halil 
Published: November 2023

AbstractPurposeTo evaluate correlation between serum iron parameters and liver T2* value in hemodialysis patients with iron overload due to parenteral iron therapy.Materials and MethodsWe evaluated 30 hemodialysis patients using a multiecho T2*‐weighted MRI sequence. Age, sex, duration of dialysis, iron and erythropoietin doses taken in the past year, and serum iron parameters were recorded. Liver T2* values were averaged from three distinct liver regions. A T2* value of 33 ± 7 ms is considered normal. Declines below 24, 21, and 14 ms signify iron overload grades 1, 2, and 3, respectively.ResultsThere was no statistically significant difference comparing the measurements of 3 different ROIs (p > 0.05). A total of 23 patients (76.6%) had iron overload. Serum ferritin levels of patients with iron overload were significantly higher than those without iron overload (687.25 [186.5–1489] ng/mL vs. 371.25 [127.5–542.5] ng/mL, p = 0.008). No linear correlation was observed between age, dialysis duration, serum iron metrics, medication doses, and T2* values. Likewise, no significant differences were found among patients based on iron overload status or its grades concerning these parameters.ConclusionWhile standard serum markers might overlook iron overload, elevated ferritin levels are promising. MRI reliably detects iron overload in patients receiving parenteral iron.
Sex‐specific dendritic morphology of hippocampal pyramidal neurons in the adolescent and young adult rats
Authors: Yarmohammadi‐Samani Parisa , Vatanparast Jafar 
Published: November 2023

AbstractCA1 and CA3 pyramidal neurons are the major sources of hippocampal efferents. The structural features of these neurons are presumed to be involved in various normal/abnormal cognitive and emotional outcomes by influencing the pattern of synaptic inputs and neuronal signal processing. Although many studies have described hippocampal structure differences between males and females, these reports mainly focused on gross anatomical features in adult or aged models, and such distinctions on neuronal morphology and dendritic spine density during adolescence, a period of high vulnerability to neurodevelopmental disorders, have received much less attention. In this work, we analyzed dendritic architecture and density of spines in CA1 and CA3 neurons of male and female rats in early adolescence (postnatal day, PND 40) and compared them with those in late adolescence/young adulthood (PND 60). On PND 40, CA1 neurons of male rats showed more Sholl intersections and spine density in apical and basal dendrites compared to those in females. The Sholl intersections in basal dendrites of CA3 neurons were also more in males, whereas the number of apical dendrite intersections was not significantly different between sexes. In male rats, there was a notable decrease in the number of branch and terminal points in the basal dendrite of CA1 neurons of young adults when compared to their sex‐matched adolescent rats. On the other hand, CA1 neurons in young adult females also showed more Sholl intersections in apical and basal dendrites compared to adolescent females. Meanwhile, the total cable length, the number of branches, and terminal points of apical dendrites in CA3 neurons also exhibited a significant reduction in young adult male rats compared to their sex‐matched adolescents. In young adult rats, both apical and basal dendrites of CA3 neurons in males showed fewer intersections with Sholl circles, but there were no significant differences in dendritic spine density or count estimation between males and females. On the other hand, young adult female rats had more Sholl intersections and dendritic spine count on the basal dendrites of CA3 neurons compared to adolescent females. Although no significant sex‐ and age‐dependent difference in neuronal density was detected in CA1 and CA3 subareas, CA3 pyramidal neurons of both male and female rats showed reduced soma area compared to adolescent rats. Our findings show that the sex differences in the dendritic structure of CA1 and CA3 neurons vary by age and also by the compartments of dendritic arbors. Such variations in the morphology of hippocampal pyramidal neurons may take part as a basis for normal cognitive and affective differences between the sexes, as well as distinct sensitivity to interfering factors and the prevalence of neuropsychological diseases.
Prostate‐derived circulating microRNAs add prognostic value to prostate cancer risk calculators
Authors: Zenner Morgan L. , Kirkpatrick Brenna , Leonardo Trevor R. , Schlicht Michael J. , Saldana Alejandra Cavazos , Loitz Candice , Valyi‐Nagy Klara , Maienschein‐Cline Mark , Gann Peter H. , Abern Michael , Nonn Larisa 
Published: November 2023

AbstractProstate cancer is the second leading cause of malignancy‐related deaths among American men. Active surveillance is a safe option for many men with less aggressive disease, yet definitively determining low‐risk cancer is challenging with biopsy alone. Herein, we sought to identify prostate‐derived microRNAs in patient sera and serum extracellular vesicles, and determine if those microRNAs improve upon the current clinical risk calculators for prostate cancer prognosis before and after biopsy. Prostate‐derived intracellular and extracellular vesicle‐contained microRNAs were identified by small RNA sequencing of prostate cancer patient explants and primary cells. Abundant microRNAs were included in a custom microRNA PCR panel that was queried in whole serum and serum extracellular vesicles from a diverse cohort of men diagnosed with prostate cancer. The levels of these circulating microRNAs significantly differed between indolent and aggressive disease and improved the area under the curve for pretreatment nomograms of prostate cancer disease risk. The microRNAs within the extracellular vesicles were the most informative and improved the AUC to 0.739 compared to the existing nomogram alone, which has an AUC of 0.561. The microRNAs in the whole serum improved it to AUC 0.675. In summary, quantifying microRNAs circulating in extracellular vesicles is a clinically feasible assay that may provide additional information for assessing prostate cancer risk stratification.
De‐implementing low‐value continuous pulse oximetry practice in infants hospitalized with bronchiolitis: A multicentre qualitative study
Authors: Yama Brie , Wahi Gita , Zhou Kim , Bayliss Ann , Sakran Mahmoud , Breen‐Reid Karen , Pound Catherine , Beck Carolyn , Friedman Jeremy , Arafeh Dana , Kanani Ronik , Parkin Patricia , Mahant Sanjay ,   For the Canadian Paediatric Inpatient Research Network (PIRN)
Published: November 2023

AbstractBackgroundClinical trial evidence supports the routine use of intermittent pulse oximetry in stabilized infants hospitalized with bronchiolitis. However, continuous pulse oximetry use is common.ObjectiveThis study aimed to understand the barriers and facilitators to de‐implement continuous pulse oximetry and implement intermittent pulse oximetry in infants hospitalized with stabilized bronchiolitis.MethodsThis multicentre qualitative study interviewed attending pediatricians, residents, nurses, respiratory therapists, and caregivers of infants hospitalized with bronchiolitis at hospitals in Ontario, Canada, to explore beliefs, attitudes, and experiences regarding pulse oximetry use in bronchiolitis management. Data were analyzed using thematic analysis to understand barriers and facilitators to practice change, mapped to the Consolidated Framework for Implementation Research (CFIR) domains.ResultsSixty‐seven participants from six hospitals were interviewed using individual interviews and focus groups. Healthcare providers emphasized the importance of identifying and understanding who is responsible for bedside pulse oximetry practice (physicians vs. nurses). Clinical experience, knowledge of guidelines, importance versus competing priorities, and the tensions among team members due to practice variation in monitoring, influenced monitoring practice. Nurses believed in the advantages of intermittent monitoring (reduced alarm fatigue, facilitation of timely discharges, and reduced workload). Clinicians identified ways to clarify indications for continuous monitoring (based on patient risk factors), versus indications to transition to intermittent monitoring (established oral feeding, sleeping without desaturations). Caregivers did not express a clear preference for monitoring type; rather, they described the need for clear communication around interpreting monitor readings, management decisions, and care transitions.ConclusionsUnderstanding professional roles, clarity around local practice standards and supporting families' understanding of pulse oximetry practice is essential for practice change. These findings may inform hospital quality improvement efforts to de‐implement continuous monitoring in bronchiolitis hospital care.
HPV co‐infections with other pathogens in cancer development: A comprehensive review
Authors: Akbari Elahe , Milani Alireza , Seyedinkhorasani Masoud , Bolhassani Azam 
Published: November 2023

AbstractHigh‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co‐infecting agents that influence infection dynamics and disease progression. Bacterial co‐infections (e.g., Chlamydia trachomatis) along with bacterial vaginosis‐related species also interact with HPV in genital tract leading to viral persistence and disease outcomes. Co‐infections involving HPV and diverse infectious agents have significant implications for disease transmission and clinical progression. This review explores multiple facets of HPV infection encompassing the co‐infection dynamics with other pathogens, interaction with the human microbiome, and its role in disease development.
Friend or foe? The impact of refurbished products in markets with network effects and standards competition
Authors: Zheng Yilong (Eric) , Wang Qi , Park Chang Hee 
Published: November 2023

AbstractThe practice of offering refurbished products has become increasingly prevalent, yet limited research has studied the potential consequences of this emerging product strategy on the market performance of the corresponding brand‐new products. This study addresses this gap by examining the impact of refurbished products in markets characterized by network effects and standards competition, while considering the developmental stage of the technology standard employed by the products. Introducing refurbished products, primarily remanufactured from returned items, can pose challenges such as sales cannibalization and negative perceptions of product quality. We propose that introducing refurbished products can also generate positive effects, because the availability of refurbished products can be perceived as an indication of sizable prior sales of the brand‐new counterparts, alleviating consumers' concerns regarding an insufficient user base and limited availability of complementary products. Our empirical and experimental studies consistently demonstrate that the availability of refurbished products adversely affects the market value and purchase intention of the corresponding brand‐new products employing established technology standards. In contrast, the introduction of refurbished products does not have such a detrimental effect on products utilizing unestablished standards. Moreover, for a specific group of consumers, this green product strategy increases their purchase intention of brand‐new products. The managerial implications of the findings are discussed.
A thorny taxonomic issue of Quaternary deer (Cervidae: Mammalia) from the South American Highlands resolved based on the recognition of a paleopathology
Authors: Avilla Leonardo Santos , Román‐Carrión José Luis , Rotti Alline 
Published: November 2023

ABSTRACTThe diversity of South American deer genera during the Quaternary is considered one of the greatest in the world. However, this was established during the beginning of the twentieth century, when the recognition of new extinct deer taxa was based only on differences in antler morphology. Thus, South American extinct deer taxa need a detailed taxonomic revision, and this is the case of the Andean deer genera Agalmaceros and Charitoceros. First, both taxa are diagnosed by the presence of thorns in their antlers. Consequently, by taxonomic priority, Agalmaceros is a senior synonym of Charitoceros. Second, we recognize here that the thorns of the antlers of Agalmaceros are the symptom of a pathology that also affects some extant deer. Excluding the thorns of the antlers, the antler of Agalmaceros is identical to that of Odocoileus virginianus, indicating that Agalmaceros is a junior synonym to this extant deer. The recognition of epizootic hemorrhagic disease as the possible cause for the thorny antlers of Andean O. virginianus and the ample record of this affecting antlers in deer from the tropical Andes suggests that an epidemic occurred in this region in the Late Pleistocene. Before describing a new taxon, taxonomists must exhaust all possibilities to explain morphological variations. In this regard, this contribution provides an interesting, important and weakly explored area in paleontology, namely taxonomic revision under a paleopathology context. With the taxonomic invalidation of Agalmaceros and Charitoceros proposed here, the diversity of South American deer genera during the Pleistocene is poorer than previously established and includes 11 taxa – seven extant and four extinct.
Sur lies élevage practice to modulate the features of red wines from calcareous soils with different textures
Authors: Pollon Matteo , Bambina Paola , Vitaggio Clara , Cinquanta Luciano , Corona Onofrio 
Published: November 2023

AbstractBackgroundIn Sicilian calcareous soils, red wines often display unripeness and bitterness features. To enhance wine quality, we employed the ‘sur lies élevage’ technique, involving prolonged contact of dead yeast cells with the wine to favor the extraction of yeast cellular components through cell lysis. The 7 month treatment utilized two types of Chardonnay lies: fresh and previously matured. To overcome challenges in retrieving lies from red winemaking, we have recovered the lies from a white winemaking. Additionally, the lies underwent a preliminary passage on a red wine to minimize color adsorption on yeast cell walls.ResultsThe sur lies treatment effectively reduced astringency, bitterness, and brown pigment in wines, with partial removal of red color. It successfully eliminated quercetin aglycone and induced remarkable changes in the aromatic profile, showing increased ethyl esters and relative fatty acids. Sensory evaluations revealed sur lies‐treated wines had fruitier and more complex characteristics compared to untreated wines. Matured lies had a greater impact on enhancing fruitiness than fresh lies.ConclusionsThe treatments mitigated the unripeness and bitterness of studied wines. Sur lies treatment improved the aromatic profile, leading to fruitier and more complex notes, enhancing overall sensory quality. Matured lies showed greater efficacy in elevating fruitiness than fresh lies. These findings highlight the value of the sur lies technique in enhancing the quality and sensory attributes of Nero d'Avola and Syrah wines from Sicilian calcareous soils. © 2023 Society of Chemical Industry.
Effects of microwave drying on physicochemical characteristics, microstructure, and antioxidant properties of propolis extract
Authors: Ozdemir Murat , Karagoz Sakine 
Published: November 2023

AbstractBACKGROUNDThe heat sensitivity of phenolics and flavonoids leads to considerable losses of these compounds during conventional drying. Microwave drying has the advantage of shorter drying time and rigorous process control, minimizing damage to heat‐sensitive compounds. Microwave drying kinetics and the impacts of microwave drying on physicochemical characteristics, morphological structure, antioxidant properties, total phenolics, and flavonoid content of propolis extract were investigated.RESULTSIncreasing the microwave power output from 180 to 900 W resulted in a 67% reduction in drying time. Morphological changes were more noticeable at higher microwave power levels as shown in scanning electron microscopy images. Water activity values of microwave dried propolis extracts were below 0.4, which satisfied the requirement for shelf‐stable dry products. The solubility of microwave dried propolis extract increased with increasing microwave power level, and the highest solubility was achieved for the propolis extract microwave dried at 900 W. Microwave dried propolis extracts exhibited lower total phenolic content levels than fresh propolis extract. The microwave power level did not affect the total flavonoid content but it affected 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free‐radical scavenging activity of microwave dried propolis extracts. The DPPH free‐radical scavenging activity closest to the fresh propolis extract was obtained for the microwave dried propolis extract at 900 W. This also showed the highest 6‐hydroxy‐2,5,7,8‐tetramethyl‐2‐carboxylic acid (Trolox) equivalent antioxidant capacity.CONCLUSIONMicrowave drying of propolis extract at 900 W was found to be the most efficient drying condition because it yielded the shortest drying time, the highest effective moisture diffusivity, and phenolic and flavonoid content levels that were very similar to those in fresh propolis extract. © 2023 Society of Chemical Industry.