bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recovery at Your Fingertips: Pilot Study of an mHealth Intervention for Work-Related Stress Among Nursing Students
Authors: Kowalski Leo , Finnes Anna , Koch Sabine , Stenling Andreas , Bujacz Aleksandra 
Published: December 2023

Abstract
Background: Work-related stress is detrimental to individual health and incurs substantial social costs. Interventions to tackle this problem are urgently needed, with mHealth solutions being a promising way of delivering accessible and standardized interventions on a wide scale. This study pilot tests a low-intensive mHealth intervention designed to mitigate the negative consequences of stress through promoting recovery strategies.
Methods: Nursing school students (N = 16) used the intervention for a month. Data were collected immediately before, immediately after, and one month after the end of the intervention. Additionally, intensive longitudinal data were collected daily during the time of the intervention. Primary outcome measures include recruitment and retention rates, engagement with and acceptability of the intervention, as well as evaluating the quality of measurement instruments.
Results: Recruitment and retention rates provide a benchmark that we need to invite 10-12 times the intended target sample size. Engagement and acceptability metrics are promising overall, showing key areas that need to be adapted to improve the intervention. Measurement quality is acceptable with instruments mostly functioning as intended.
Discussion: Results show that the intervention and study protocol are feasible for conducting a randomized controlled trial given a few adjustments. The randomization algorithm needs to match the sample size in order to allocate evenly distributed experimental groups. Acceptability of the intervention may be improved through adapting the recommended recovery strategies. Some additional outcome measures are suggested to provide a more comprehensive picture of intervention effects.
Fire effects on soil biota alter the strength and direction of plant-soil feedbacks
Authors: Hopkins Jacob , Bennett Alison E. 
Published: December 2023

Abstract
Background and aims
Plant soil feedbacks (PSF) are reciprocal mechanisms through which plants modify soil biota and affect future plant growth. When scaled up to the community level, PSFs are important determinants of above- and belowground community dynamics that influence long-term successional trajectories. Despite over three decades of ecological PSF research, we have a poor understanding of how common environmental processes like fire influence the strength and direction of PSFs.
Methods
In this work we evaluated how fire effects on Schizachyrium scoparium and Rudbeckia hirta trained soil biota influenced feedbacks on plant growth. We tested this by experimentally manipulating fires and evaluating plant growth responses to burned and unburned inter- and intraspecific soil biota treatments.
Results
Fire effects on inocula neutralized negative feedbacks in S. scoparium, and caused negative feedbacks in R. hirta. This shows that environmental disturbance like fire can alter the strength and direction of PSFs in ways that potentially modify plant growth, plant fuel loads, and community dynamics.
Conclusion
That fire can alter the strength and direction of PSFs on plant growth suggests that fire effects on soil related processes contribute to plant community assembly and fire-fuel dynamics in fire recurrent grassland and savanna ecosystems. Further, this study shows that fire effects on PSFs vary between plant species, and may contribute to the dominance of C4 grasses in pyrophilic ecosystems.
Comparing the effectiveness of real-time PCRs to simultaneously detect and identify viable Globodera pallida and G. rostochiensis.
Authors: Lombard Lorenzo , Dekker-Nooren C.C.E.M. , Wuijster B. , Duivenbode I. van , Bruggen A.S. van , Heese E.Y.J. van 
Published: December 2023

Abstract

Recently, the Commission Implementation Regulation (CIR) 2022/1192 has been published in Europe, prescribing regulations on eradication measures for quarantine potato cyst nematodes including mandated assays for species identification. The CIR 2022/1192 provides a derogation on the use of Beniers et al. (2014) real-time PCR as the validation process was still ongoing. In this study, the validation of a modified version of the Beniers real-time PCR was carried out, following EPPO Standard PM 7/98. Furthermore, the performance was compared to the conventional PCR of Bulman & Marshall (1997) and the Gamel et al. (2017) real-time PCR, both DNA based, which are mandated by CIR 2022/1192. Additionally, the effect of cyst viability was compared for the two real-time PCR assays. The modified Beniers real-time PCR met all validation performance criteria, with analytical sensitivity of 1 living egg for both target Globodera pallida and G. rostochiensis and scoring 100% for analytical specificity, reproducibility, robustness and diagnostic specificity. The viability assays showed that the DNA based Gamel real-time PCR provided positive results for non-viable cysts in contrast to the modified RNA based Beniers real-time PCR. Based on the results of this study, the modified Beniers qualifies for the detection and identification of Globodera pallida and G. rostochiensis and performs at least equally well as the other two PCR assays. For development and improvement of diagnostic protocols, it is recommended that competent authorities should be allowed to use recognized diagnostic protocols when in-house validated instead of only mandated tests as prescribed by CIR 2022/1192.
When to attend? Temporal attention interacts with expectation
Authors: Duyar Aysun , Ren Shiyang , Carrasco Marisa 
Published: December 2023

Abstract
Temporal attention is voluntarily deployed at specific moments, whereas temporal expectation is deployed according to timing probabilities. When the target appears at an expected moment in a sequence, temporal attention improves performance at the attended moments, but the timing and the precision of the attentional window remain unknown. Here we independently and concurrently manipulated temporal attention–via behavioral relevance–and temporal expectation–via session-wise precision and trial-wise hazard rate–to investigate whether and how these mechanisms interact to improve perception. Our results reveal that temporal attention interacts with temporal expectation–the higher the precision, the stronger the attention benefit, but surprisingly this benefit decreased with delayed onset despite the increasing probability of stimulus appearance. When attention was suboptimally deployed to earlier than expected moments, it could not be reoriented to a later time point. These findings provide evidence that temporal attention and temporal expectation are different mechanisms, and highlight their interplay in optimizing visual performance.
A Comprehensive Input-Output Analysis Model for Quantifying Environmental Linkages and Leakages: Evidence from Greece
Authors: Tsirimokos Christos 
Published: December 2023

Abstract
This paper introduces a novel approach to simultaneously estimate total (direct and indirect) greenhouse gas (GHG) emissions linkages and leakages by employing both the Leontief demand-driven and Ghosh supply-driven input-output (I-O) models. Using the Greek economy as a case study the paper contributes to the research field of environmental interindustry linkage analysis by evaluating the impact of international trade on the carbon footprint of national economies. The analysis identifies industries with significant emissions linkages and leakages, highlighting the potential for domestic input substitution as a means to reduce GHG emissions. This approach offers valuable insights for the formulation of targeted mitigation policies, contributing to the pursuit of sustainable development goals.
Factors associated with treatment outcomes of severe acute malnutrition among under five children admitted at Queen Elizabeth Central Hospital (QECH) nutrition unit: A retrospective cross-sectional study
Authors: Ndhlovu Mirriam , Pajogo Masuzgo 
Published: December 2023

Abstract
Introduction: SAM affects 17 million under-5 children globally, of which 4.4 million are from sub-Saharan Africa. About 1 million SAM children die every year. Despite Malawi’s efforts to reduce child mortality, inpatient mortality among SAM children has remained high. This study was aimed at assessing factors associated with treatment outcomes among SAM children aged 1 to 59 months admitted to QECH.
Methods: This was a retrospective cross-sectional study. A data collection tool was used to collect data from the medical files of the children aged 1 to 59 months admitted at QECH NRU from 2017 to 2020. Systematic random sampling was done to select the medical files. Bivariate and multivariate logistic regressions were conducted to assess associations. The statistical significance was declared when the p-value was less than 0.05
Results: Male SAM children constituted 55%, and the age ranged from 6 to 59 months with a median of 18 months. About 21% of SAM children died, 77% were transferred to OTP, and 2% defaulted. Characteristics that were associated with mortality were stopping breastfeeding [ARRR:3.2 (95%CI: 1.1- 9.3)], pneumonia [ARRR:3.1 (95%CI:1.2-8.1)], dehydration [ARRR:6.6 (95% CI: 2.0-22)], sepsis [ARRR:2.8 (95%CI:1.1-7.0)], unknown breastfeeding status [ARRR:14.9 (95%CI:2.4-91.8)], and unknown hypoglycaemia in the ward [ARRR 0.04 (95% CI 0.02-0.1)].
Conclusion: Early detection of life-threatening conditions, timely management of associated medical comorbidities, and adhering to WHO SAM inpatient management protocols might be effective in reducing SAM case fatality estimates.
Quantification of the flexural rigidity of endovascular surgical devices using three-point bending tests
Authors: Qiu Michael Y. , Suskin Charles B , Becerra-Garcia Juan J , Roberts Sophia H , Rucker DeVaughn G , Zayed Mohamed A , Osbun Joshua W , Genin Guy M 
Published: December 2023

Abstract
Endovascular surgical procedures require the navigation of catheters and wires through the vasculature to reach distal target sites. Quantitative frameworks for device selection hold the potential to improve the tracking of endovascular devices through vascular anatomy by personalizing the device flexural rigidity to an individual‚Äôs anatomy. However, data are lacking to facilitate this technology, in part because typical endovascular devices have intricate spatial variations in mechanical properties that are challenging and tedious to quantify repeatably. We therefore developed a three-point bend test methodology using a custom rig and applied it to measure lengthwise flexural rigidity profiles of endovascular devices that are used to target the cerebral vasculature. The methodology demonstrated high repeatability and was able to characterize transition zones. We applied the methodology to generate the first comprehensive, quantitative library of device flexural rigidities, spanning guidewires, intermediate guides, and long sheaths. We observed that these three classes of device have properties that fall into distinct ranges. Additional plots examining relationships between flexural rigidity, device diameter, and length revealed application-specific trends in flexural properties. This methodology and the data allow for standardized characterization and comparisons to aid device selection, and have the potential to both enhance surgical planning and inform future innovation.
Prenatal exposure to perfluorooctanoic acid and childhood allergic diseases: a prospective birth cohort study
Authors: Tang Xiaoyu , Chen Qian , Liu Quanhua , Chen Mengxue , Jin Shengjie , Zhang Jun , Zhang Jianhua , Hua Li 
Published: December 2023

Abstract
Background
Perfluorooctanoic acid (PFOA) is widely used in daily life, however, research has shown its immune suppression function. Our aim is to investigate the relationship between prenatal exposure to PFOA and allergic diseases in children.
Methods
A prospective birth cohort study involving 648 pregnant women was conducted. Prenatal information was collected by an interview with the women and from medical records. Fetal umbilical cord blood was collected, and concentration of PFOA and genotype of IL-13 rs20541 were detected. Children were followed at 6, 12 and 24 months and information on the development of allergic diseases was recorded. Multivariate logistic regression analysis was used to examine the association between PFOA and allergic diseases. Stratified analysis was performed based on gender and genotype of IL-13 rs20541.
Results
In multivariate adjusted models, the highest PFOA quartile is associated with odds of atopic dermatitis (AD) (OR 1.66, 95% CI 1.09–2.55), wheezing (OR 4.06, 95% CI 1.30-12.68), and allergic diseases (OR 1.71, 95% CI 1.15–2.54). Female patients with the highest PFOA quartile have a higher odd of AD (OR 2.25, 95% CI 1.20–4.23) and allergic diseases (OR 1.93, 95% CI 1.07–3.46). Patients with GG genotype of IL-13 rs20541 and the highest PFOA quartile also have a higher odd of AD (OR 2.82, 95% CI 1.41–5.67), wheezing (OR 15.16, 95% CI 1.38-166.59), and allergic diseases (OR 2.42, 95% CI 1.27–4.61).
Conclusions
Prenatal exposure to PFOA increases the risk of developing allergic diseases in children, especially for the female patients and those with the genotype of IL-13 rs20541 GG.
C6orf15 promotes liver metastasis via WNT/β-catenin signaling in colorectal cancer
Authors: Yu Jiankang , Sun Jian , Tang Jingtong , Xu Jiayu , Qian Guanru , Zhou Jianping 
Published: December 2023

Abstract
Background:
Colon cancer ranks third among global tumors and second in cancer-related mortality, prompting an urgent need to explore new therapeutic targets. C6orf15 is a novel gene currently reported only in Sjogren's syndrome and systemic lupus erythematosus. We found a close correlation between increased C6orf15 expression and the occurrence of colon cancer. This study aims to explore its potential as a therapeutic target for colorectal cancer.
Method:
RNA-seq differential expression analysis of the TCGA database was performed using the R package 'limma.' The correlation between target genes and survival as well as tumor analysis was analyzed using GEPIA. Utilization of western blot and PCR to assess C6orf15 expression in colorectal cancer tissue samples. Immunofluorescence and Immunohistochemistry for subcellular localization and expression assessment in tissues. Confirmation of C6orf15's role in liver metastasis progression via a mouse spleen infection liver metastasis model. Assessment of C6orf15's association with signaling pathways using GSEA-Hallmark Database. Immunohistochemistry (IHC), qPCR and western blot were performed to measure related mRNA or protein expression. Evaluation of biological characteristics through Cell Migration&Invasion Assays, MTT Assay, and SeahorseXF96 to monitor fatty acid metabolism.
Results:
C6orf15 was significantly associated with liver metastasis and survival in CRC by
bioinformatics analysis and was further verified by Immunohistochemistry (IHC), qPCR and western blot. Upregulation of C6orf15 in CRC cells can promote nuclear translocation of β-catenin and cause an increase in downstream transcription. This leads to changes in epithelial-mesenchymal transition (EMT) and alterations in fatty acid metabolism, which together promote liver metastasis of colorectal cancer.
Conclusion:
Our study identified C6orf15 as a marker of liver metastasis in CRC. C6orf15 can activate the WNT/β-catenin signaling pathway to promote EMT and fatty acid metabolism in colorectal cancer.
Research on the development strategy of rural cultural and tourism integration from the perspective of big data Take Pingwang Town Suzhou as an example
Authors: Fang Zhigou , Liu Cong , Zhang Qian , Jin Chenghao 
Published: December 2023

Abstract
The integration of rural culture and tourism is an important means to prosper the rural economy, inherit rural culture, promote rural transformation and development, and increase farmers' employment and income. Taking Pingwang Town as an example, this paper excavates rural cultural communication texts and tourism experience texts, and analyzes the content, integration quality, integration value and integration popularity of rural culture and tourism by using word frequency analysis, sentiment analysis, semantic network analysis and POI heat analysis, and constructs an evaluation framework for rural cultural tourism integration. Combined with the analysis results of the evaluation framework, optimization strategies are proposed from the aspects of industrial upgrading, regional culture and brand marketing, so as to provide theoretical support for the integrated development of urban and rural areas and the comprehensive revitalization of rural areas.
An approach based on clustering for detecting differentially expressed genes in microarray data analysis
Authors: Ando Yuki , Shimokawa Asanao 
Published: December 2023

Abstract
To identify differentially expressed genes (DEGs), researchers used a testing method for each gene. However, microarray data are often characterized by large dimensionality and a small sample size, which lead to problems such as reduced analytical power and increased number of tests. Therefore, we propose a clustering method. In this method, genes with similar expression patterns are clustered, and tests are conducted for each cluster. This method increased the sample size for each test and reduced the number of tests. In this case, we used a nonparametric permutation test in the proposed method because independence between samples cannot be assumed if there is a relationship between genes. We compared the accuracy of the proposed method with that of conventional methods. In the simulations, each method was applied to the data generated under a positive correlation between genes, and the area under the curve, power, and type-one error were calculated. The results show that the proposed method outperforms the conventional method in all cases under the simulated conditions. We also found that when independence between samples cannot be assumed, the non-parametric permutation test controls the type-one error better than the t test.
Alcohol consumption and the risk of miscarriage: a meta-analysis of observational studies.
Authors: Xu Haoyi , Cui Hengfang , Huang Yinhua , Xu Xingwei 
Published: December 2023

Abstract
Background: The objective of this meta-analysis was to evaluate the correlation between maternal alcohol consumption before and during pregnancy and the risk of miscarriage.
Methods: As of 31 May 2023, studies searched by using PubMed, Embase, and the Cochrane Library, as well as keywords and MeSH terms. Stata and Review Manager were used for statistical analysis. Individual study estimates were pooled using random effects (if heterogeneity, I2 ≥ 50% and p < 0.05) or fixed effects (if heterogeneity, I2 < 50% and p > 0.05) meta-analysis. Publication bias was evaluated through a funnel plot and Egger's test.
Results: A total of 19 studies were included in this analysis. The pooling analysis demonstrates that alcohol consumption prior to conception is linked to an elevated risk of miscarriage (OR = 1.05; 95% CI: 1.03-1.08). Furthermore, alcohol consumption during pregnancy is associated with an increased risk of miscarriage (OR = 1.36; 95% CI: 1.18-1.57). Subgroup analysis reveals that both light (OR = 1.06; 95% CI: 1.04-1.09) and moderate (OR = 1.06; 95% CI: 1.03-1.08) alcohol intake before pregnancy is linked to an elevated risk of miscarriage. Similarly, light (OR = 1.08; 95% CI: 1.02-1.15), moderate (OR = 1.26; 95% CI: 1.07-1.49), and heavy (OR = 1.87; 95% CI: 1.21-2.89) alcohol consumption during pregnancy is associated with an increased risk of miscarriage.
Conclusions: Our study identified a potential association between alcohol consumption, both before and during pregnancy, and the risk of miscarriage. Accordingly, it is advisable for women preparing for pregnancy to refrain from alcohol consumption.
The protocol of the study was registered in PROSPERO with the identification number CRD42023430749.
Determinants for the need for blood transfusion in trauma patients admitted to the emergency ward: a case-control study
Authors: Golbakhsh Mohammad Reza , Soleimani Mohammad , Gholamshahi Hediye , Shafiei Seyyed Hossein , Fallah Yousef , Ghaseminejad-Raeini Amirhossein 
Published: December 2023

Abstract
Introduction:
Trauma is a major cause of death in hospitals around the world according to the World Health Organization (WHO). Massive transfusion (MT) has specific indications in many trauma centers in the United States, but the need for definite criteria and indications for MT remains. In this study, we try to define exact indications of whether and/ when a trauma patient needs PRBCs transfusion, or even how much transfusion may be needed.
Methods:
This study was a retrospective analysis of the prospectively collected data of the trauma patients that have been registered in the National Trauma Registry of Iran (NTRI) from July 2016 to October 2021. Age, sex, body mass index (BMI), preexisting cardiovascular problems, endocrine issues, kidney dysfunction. Gastrointestinal diseases, whether or not the patient had multiple trauma, obesity, systolic blood pressure, pulse rate, temperature, Oxygen saturation, Glasgow coma scale (GCS), and injury severity score (ISS) were the principal variables of this study.
Results:
Hypotension, temperature > 37º, hyperpnea, and O2 saturation < 90% were significantly more prevalent among PRBCs receivers. Hypertension, tachycardia, and bradycardia were more prevalent as well, but the difference was not statistically significant. In terms of trauma scores, Glasgow Coma Scale (GCS) ≤ 8, and both ISS 9–14 and ≥ 15 had more chance of needing PRBCs transfusion which was meaningful, but GCS 14 − 9 didn’t prove significant chances.
Conclusion:
Based on these criteria, we can estimate if a patient will need a blood transfusion and make a PRBC reservation in the blood bank.
The Effect of Education and Positive Social Behaviour on Attitudes to Organ Donation: A Quasi-Experimental Study
Authors: SOYLU Ayşe , SOYLU Dilek 
Published: December 2023

Abstract
Objective
The aim of this study was to determine the effect of education and positive social behaviour on attitudes to organ donation.
Material and Methods
This analytical interventional study was designed as an observational, cross-sectional, questionnaire-based, single-arm, semi-experimental study. A Personal Information Form, the Attitudes to Organ Donation Scale (AODS), and the Online Positive Social Behaviour Scale (OPSBS) were used in the collection of the research data before and after the delivery of education about organ donation.
Results
There was seen to be a statistically significant increase after the education in the AODS attitude (p = 0.048), subjective (p = 0.000), and total (p = 0.007) mean points. There was determined to be a statistically significant relationship between the AODS intention and attitude subscales and the applied and total OPSBS points (p < 0.05). A statistically significant relationship was determined between the perceived behavioural control subscale and AODS total points and all the OPSBS subscales (p < 0.001).
Conclusions
Education given on the subject of organ donation and positive social behaviour were determined to have an effect on organ donation. With education given by nurses, a positive attitude to organ donation and the development of social behaviour can be provided, thereby contributing to an increase in the number of donated organs in Turkey.