bluuebunny/crossref_metadata_2025_split huggingface dataset:
Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients
Authors: Navab Fatemeh , Foshati Sahar , Bagherniya Mohammad , Askari Gholamreza , Moeinzadeh Firouzeh , Gholaminejad Alieh , Clark Cain C. T. , Rouhani Mohammad Hossein 
Published: December 2023

AbstractInflammation plays an important role in Cardiovascular disease (CVD) pathogenesis as the main cause of mortality in hemodialysis (HD) patients. Despite the relevance of nutrition and dietary intakes for inflammation status, the role of dietary protein sources remains unclear. The aim of this study was to evaluate the association between the different types of dietary protein and pentraxin 3 (PTX3) levels in HD patients. In this multi-center cross-sectional study, 227 adult patients undergoing HD for a minimum 90 days were recruited. A validated 168-item food frequency questionnaire was used to assess dietary intakes. Also, 5 ml blood samples were collected from each patient to measure the concentration of serum PTX3. Overall, 227 patients, including 63 women and 164 men, with a mean age of 58 years, participated in this study. There was a greater intake of animal protein per kilogram dry weight among patients with higher levels of PTX3 (0.46 vs. 0.54 g/kg; P = 0.035). In contrast, consumption of total protein and plant protein per kilogram dry weight was not different across PTX3 levels. Moreover, the chance of increased PTX3 concentration was directly associated with a one-unit increase in animal protein intake per kilogram dry weight, after adjusting for confounders. We did not observe any association between one-unit increases in plant protein intake per kilogram dry weight and chance of increased PTX3. In conclusion, animal protein intake was directly associated with circulating PTX3.
Low-frequency magnetic response of gold nanoparticles
Authors: Harke Saba , Habibpourmoghadam Atefeh , Evlyukhin Andrey B. , Calà Lesina Antonio , Chichkov Boris N. 
Published: December 2023

AbstractGold nanoparticles (AuNPs) exposed to low frequency magnetic fields have shown promise in enhancing biological processes, such as cellular reprogramming. Despite the experimental evidence, a comprehensive understanding of the underlying physical principles and the corresponding theory remains elusive. The most common hypothesis is that functionalized nanoparticles transiently amplify magnetic fields, leading to improved cellular reprogramming efficiency. However, a detailed investigation on this topic is lacking. This paper bridges this knowledge gap by conducting a comprehensive investigation on the magnetic response of surface-modified AuNPs exposed to magnetic fields with frequencies up to hundreds of MHz. Starting with the inherent properties of bulk gold material, we explore a wide range of magnetic susceptibilities that might result from the redistribution of charge carriers due to bond molecules on the particle surfaces. Through analytical models and numerical electromagnetic simulations, we examine various geometric factors that can enhance the magnetic response, including the number of particles, spatial distribution, size, and shape. Our broad investigation provides researchers with analytical and numerical estimates of the magnetic response of nanoparticles, and the associated limits that can be expected. We found that a magnetic field enhancement comparable to the incident field requires very high magnetic susceptibilities, well beyond the values measured in functionalized gold nanoparticles thus far.
CETP and APOA2 polymorphisms are associated with weight loss and healthy eating behavior changes in response to digital lifestyle modifications
Authors: Kim Meelim , Lee Seolha , Cho Eun , Hong Kyung-Won , You So-Jin , Choi Hyung Jin 
Published: December 2023

AbstractResponse to digital healthcare lifestyle modifications is highly divergent. This study aimed to examine the association between single nucleotide polymorphism (SNP) genotypes and clinical efficacy of a digital healthcare lifestyle modification. We genotyped 97 obesity-related SNPs from 45 participants aged 18–39 years, who underwent lifestyle modification via digital cognitive behavioral therapy for obesity for 8 weeks. Anthropometric, eating behavior phenotypes, and psychological measures were analyzed before and after the intervention to identify their clinical efficacy. CETP (rs9939224) SNP significantly predict “super-responders” with greater body mass index (BMI) reduction (p = 0.028; GG − 2.91%, GT − 9.94%), while APOA2 (rs5082) appeared to have some potential for predicting “poor-responders” with lower BMI reduction (p = 0.005; AA − 6.17%, AG + 2.05%, and GG + 5.11%). These SNPs was also associated with significant differences in eating behavior changes, healthy diet proportions, health diet diversity, emotional and restrained eating behavior changes. Furthermore, classification using gene–gene interactions between rs9939224 and rs5082 significantly predicted the best response, with a greater decrease in BMI (p = 0.038; − 11.45% for the best response group (CEPT GT/TT × APOA2 AA) vs. + 2.62% for the worst response group (CEPT GG × APOA2 AG/GG)). CETP and APOA2 SNPs can be used as candidate markers to predict the efficacy of digital healthcare lifestyle modifications based on genotype-based precision medicine.Trial registration: NCT03465306, ClinicalTrials.gov. Registered March, 2018.
Association of WHSC1/NSD2 and T-cell infiltration with prostate cancer metastasis and prognosis
Authors: Li Qiheng , Zhu Jiang , Zhang Yang , Pan Yun , Li Zhengjin , Wang Min , Gao Yixuan , Feng Dongmei , He Xiaoyong , Zhang Chunmei 
Published: December 2023

AbstractProgress in immunotherapy for prostate cancer (PCa) lags that for other cancers, mainly because of limited immune infiltration in PCa. This study aimed to assess the feasibility of NSD2 as an immunotherapeutic target in PCa. Immunohistochemistry was performed to evaluate the expression pattern of NSD2 in 34 cases of benign prostatic hyperplasia (BPH), 36 cases of prostatic intraepithelial neoplasia (PIN), and 57 cases of PCa, including 19 cases of metastatic castration-resistant prostatic cancer (mCRPC). Single-cell RNA sequencing and gene set enrichment analysis (GSEA) were used to correlate NSD2 with certain downstream pathways. Furthermore, the Immuno-Oncology-Biological-Research (IOBR) software package was used to analyze the potential roles of NSD2 in the tumor microenvironment. We found that the positive expression rate of NSD2 increased progressively in BPH, PIN and PCa. mCRPC had the highest staining intensity for NSD2. High NSD2 expression was positively correlated with the infiltration level of CD4+ tumor-infiltrating lymphocytes (TILs) and negatively correlated with that of CD8+ TILs. Importantly, a new immune classification based on NSD2 expression and CD4+ TILs and CD8+ TILs was successfully used to stratify PCa patients based on OS.PSA and CD4+ TILs are independent risk factors for PCa bone metastasis. This study demonstrates a novel role for NSD2 in defining immune infiltrate on in PCa and highlights the great potential for its application in immunotherapy response evaluation for prostate malignancies.
Optimizing the thermophysical qualities of innovative clay–rGO composite bricks for sustainable applications
Authors: Soliman Wafaa , Shahat M. Abdelhamid 
Published: December 2023

AbstractThis work concerned the development of a unique reduced graphene oxide (rGO) nano-filler to provide innovative opportunities in enhancing the thermophysical performance of clay composite bricks. Whereas, a series of clay–rGO composite bricks were produced, doped with various levels of rGO nanosheets (i.e., 0, 1, 2, 4, and 6 wt% clay). Each clay–rGO composite’s microstructure, shrinkage, morphology, density, porosity, and thermophysical characteristics were carefully investigated, and the thermal conductivity performance was optimized. Incorporation of different levels of rGO NPs to the clay matrix allowed all the peaks intensity to rise relative to the untreated one in the XRD pattern. Meanwhile, the inclusion of these doping resulted in a grew in the crystallite sizes and apparent porosity within the compositions. In this vein, shrinkage fracture of fabricated brick composites varied depending on dopants type and levels during the drying and firing processes. Moreover, there are some changes in chemical compositions, as well as wave shifts, suggesting that functional groups of rGO may have contributed to partially introduce carbonyl groups in clay–rGO composites. Besides, the porous topography and bulk density improved rapidly with respect to the plane of the rGO nanosheets within the composites. The differ-dense microstructure displayed in the SEM micrographs supports these outcomes. Remarkably, clay–(4%)rGO compound not only has an optimum thermal conductivity value (0.43 W/mK), but it also has a high heat capacity (1.94 MJ/m3K). These results revealed the exceptional features of rGO sheets such as large surface area with high porosity within the modified clay composites.
Klinische Neurophysiologie im Wandel, eine neue Schriftleitung
Authors: Grimm Alexander , Marquetand Justus 
Published: December 2023

Klinische Neurophysiologie im Wandel, eine neue SchriftleitungLiebe Leserinnen und
Leser,auch die Klinische Neurophysiologie ist stets im Wandel der Zeit: Nachdem
Prof. Dr. Buchner zuletzt die Schriftleitung der Klinischen Neurophysiologie inne
hatte und die ihm damit übertragenen Aufgaben vorbildlich erfüllte,
wird der Staffelstab an zwei Vertreter der nächsten Generation
übergeben.
Impfungen bei Erwachsenen mit Diabetes
Authors: Witzke Oliver 
Published: December 2023

ZUSAMMENFASSUNGImpfungen stellen die wichtigsten Präventionsmaßnahmen in der Medizin dar, und ihre medizinische und gesellschaftliche Relevanz wurde in der zurückliegenden Pandemie deutlich. Menschen mit Diabetes besitzen aufgrund eines geschwächten Immunsystems ein erhöhtes Risiko für Infektionskrankheiten. Daher ordnet die Ständige Impfkommission (STIKO) diese Patient*innen als Risikogruppe ein und hat einige Impfempfehlungen angepasst. Die folgende Übersicht bündelt die aktuell relevanten Standard- und Indikationsvakzinierungen für Erwachsene mit Diabetes mellitus und liefert mit der RSV-Impfung auch einen Ausblick auf eine mögliche zukünftige Ergänzung.
Systematische Parodontitistherapie und
Kieferorthopädie
Authors: Hoedke Daniela , Dommisch Henrik 
Published: December 2023

ZusammenfassungDie aktuelle Klassifikation parodontaler und peri-implantärer
Erkrankungen und Zustände teilt die Parodontitis in vier Schweregrade
(Stadium I-IV) und drei Progressionsgrade (Grad A-C) ein. Die erste, 2020 von
der Europäischen Föderation für Parodontologie (EFP)
verabschiedete und 2021 in Deutschland von der Deutschen Gesellschaft
für Parodontologie (DG PARO) implementierte Leitlinie zur Therapie der
Parodontitis adressiert die Stufen I-III der Parodontitis und beinhaltet deren
systematische, stufenweise Behandlung. In der 2022 verabschiedeten Leitlinie zur
Therapie der fortgeschrittenen Parodontitis (Stadium IV) werden
interdisziplinäre Behandlungskonzepte verschiedener zahnmedizinischer
Disziplinen beschrieben, deren Evidenz bewertet und daraus
Behandlungsempfehlungen abgeleitet. Dieser Artikel soll eine Übersicht
zur Klassifikation der parodontalen Erkrankungen geben und die systematische
Parodontitistherapie unter besonderer Berücksichtigung der
kieferorthopädischen Behandlung von Patienten mit Parodontitis
zusammenfassen.
Dengue a global threat: An insight into management and control
Authors: Jamil Muhammad , Saleem Ashiq , Naz Rida , Ahmad Sajad , Ramzan Faiqah , Ali Mubarik , Jabeen Norina 
Published: December 2023

Abstract

Background
: Dengue, whose severe forms have the potential to be fatal, is the most prevalent and rapidly proliferating vector-borne viral disease worldwide. It is evolving as a significant public health and economic dilemma for both rural and urban communities.
Objectives
: Given the urgent need for control measures, the purpose of this study is to evaluate both traditional and contemporary preventive strategies.
Results
: Traditional dengue control measures, while somewhat effective, tend to provide only temporary relief. In contrast, biotechnological innovations such as paratransgenesis, sterile insect technology, and genetically modified vectors have increased the effectiveness of conventional methods. In addition, the novel discovery of vaccines and immunotherapies offers a promising avenue for the management of dengue.
Discussion & Conclusion:
Integration of time-tested techniques with the most recent biotechnological interventions emerges as a crucial dengue-prevention strategy. While these developments offer cause for optimism, additional research is required to determine the long-term implications and viability of these techniques.
Implications
: The findings have significant implications for theory, policymaking, and medical practice, highlighting the need for a combined approach to dengue management.
Disparities in acute myeloid leukemia treatments and outcomes
Authors: Eisfeld Ann-Kathrin 
Published: December 2023

Purpose of review
This review aims to summarize different contributors to survival disparities in acute myeloid leukemia (AML) patients. The focus is set on African-American (hereafter referred to as Black) patients, with separate consideration of self-reported race and ancestry. It aims to also highlight the interconnectivity of the different features that impact on despair survival.

Recent findings
The main themes in the literature covered in this article include the impact of social deprivation, clinical trial enrollment and biobanking, structural racism and ancestry-associated differences in genetic features on survival outcomes.

Summary
An increasing number of studies have not only shown persistent survival disparities between Black and non-Hispanic White AML patients, but uncovered a multitude of contributors that have additive adverse effects on patient outcomes. In addition to potentially modifiable features, such as socioeconomic factors and trial enrollment odds that require urgent interventions, there is emerging data on differences in disease biology with respect to genetic ancestry, including frequencies of known AML-driver mutations and their associated prognostic impact.
A modified RGB trichrome (HemRGB) for improving nuclear staining: application to colorectal cancer histopathology
Authors: Gaytán Francisco 
Published: December 2023

AbstractThe RGB trichrome staining method has been used to highlight two major components of the extracellular matrix, collagen and glycosaminoglycans. While the RGB trichrome efficiently stains extracellular matrix components, it lacks a nuclear stain, limiting its application in histopathology. To address this issue, a modification of the original stain, named HemRGB trichrome, has been developed. This modification incorporates iron hematoxylin for improving nuclear staining while retaining specificity for the staining of extracellular matrix. The application of HemRGB trichrome staining to samples from both normal colonic tissues and colorectal adenocarcinomas (CRC) provides a robust nuclear staining, together with a high-contrasted staining of tumor microenvironmental components, such as infiltrating immune cells, collagen and ground substance, extracellular mucins, as well as contrasted interfaces between CRC metastases and liver parenchyma. This study underscores the potential of HemRGB trichrome as a valuable tool for histopathological studies, especially for cancer evaluation, where nuclear characteristics are particularly relevant.
Internal Dynamics Interact with Proprioceptive Feedback During Movement Execution in an RNN Model of Motor Cortex
Authors: Jiang Hongru , Bu Xiangdong , Zheng Zhiyan , Pan Xiaochuan , Chen Yao 
Published: December 2023

ABSTRACTProprioceptive feedback provides the information about the state of the body, which is critical in motor control. However, the contribution of proprioceptive feedback to motor cortical activity during voluntary movement execution is unclear. Here, we built an recurrent neural network model of motor cortex that receives proprioceptive feedback, and optimized it to control a virtual arm to perform a delayed-reach task. Simulated neural activity is similar to real data, indicating that our model captures the motor cortical dynamics. We further disrupted recurrent connectivity and proprioceptive feedback to dissect their contribution, and found that internal dynamics dominate in neural population activity, while proprioceptive feedback controls movement termination. Moreover, proprioceptive feedback improves the network’s robustness against noisy initial conditions. We further investigated the relative importance of the components in proprioceptive feedback and found that the feedback of hand velocity contributes most to the similarity between simulation and real data. Finally, we show that our motor cortex model can be implemented in the sensorimotor system, demonstrating our model’s biological plausibility. In summary, motor command may arise from the intersection between recurrent dynamics in motor cortex and proprioceptive feedback.
Vagus nerve stimulation by focused ultrasound attenuates acute myocardial ischemia/reperfusion injury predominantly through cholinergic anti-inflammatory pathway
Authors: Zhang Qian , Cai Qianyun , Zhong Shenrong , Li Qin , Qiu Weibao , Wu Juefei 
Published: December 2023

AbstractBackgroundThe invasive method using electrically stimulating vagus nerve has been demonstrated to inhibit the inflammatory response against acute myocardial ischemia/reperfusion(I/R) injury. This neuro-regulatory technique used is invasive implantation of electrical stimulators which have the risk of infection and other complications. A non-invasive method of vagus nerve stimulation applying on acute myocardial I/R injury is particularly important and desirable.ObjectivesThis study aimed to test the hypothesis that focused ultrasound stimulation(FUS) of vagus nerve attenuates acute myocardial I/R injury through cholinergic anti-inflammatory pathway.MethodsThis study was completed with two parts. In the first part, ischemia was induced by left anterior descending coronary artery (LAD) occlusion for 30 minutes (min), followed by 2 hours (h) of reperfusion, FUS lasted for 50 min after reperfusion for 10 min. Infammatory markers, arrhythmia score, histopathology, infammatory markers α7 nicotinic acetylcholine receptor (α7nAchR) protein were determined. In the second part, ischemia was induced by LAD occlusion for 30 min, followed by 24h of reperfusion, FUS lasted for 50 min after reperfusion for 10 min. Myocardial fibrosis, infarct size, echocardiographic measurements, biomarkers of pro-oxidative stress, antioxidant and myocardial apoptosis were determined.ResultsFUS of vagus nerve significantly decreased the level of infammatory markers in I/R+FUS group compared with the I/R group, I/R+vagotomy group and I/R+vagotomy+FUS group. FUS decreased the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF), while also reduced arrhythmia score in I/R+FUS group compared with the I/R group. These improvements were associated with the inhibition of acute inflammatory reaction through cholinergic anti-inflammatory pathway. FUS limited myocardial fibrosis and infarct size, preserved left ventricular function. This cardioprotective effect was associated with alleviation of apoptosis and oxidative stress.ConclusionsThe noninvasive method of ultrasonic neuromodulation using FUS of vagus nerve exerted protective effects on acute myocardial I/R injury. Its potential mechanisms involved the suppression of acute inflammatory reaction through cholinergic anti-inflammatory pathway.
Nonstate ownership, agency costs and corporate performance: evidence from Chinese state-owned enterprises
Authors: Chen Qi-an , Bao Anze , Chen Junpei , Lu Yi 
Published: December 2023

PurposeThe primary objective of introducing nonstate ownership into state-owned enterprises (SOEs) is to enhance corporate performance. This study explores how nonstate ownership affects corporate performance, emphasizing agency costs as the primary mechanism.Design/methodology/approachUsing data from 2010 to 2019 for listed SOEs, the authors measure nonstate ownership based on shareholding ratios, control rights and shareholding–control matching. The authors also use fixed-effects and mediation-effects models, with agency costs as the primary mechanism.FindingsIncreased nonstate shareholding ratios, stronger control rights and improved shareholding–control matching promote SOE performance. Nonstate shareholding ratios boost performance through resource effects, while control rights and shareholding–control matching promote performance by mitigating agency costs. A heterogeneity analysis indicates stronger effects in local SOEs and highly marketized regions. Moreover, control rights and shareholding–control matching reinforce the positive impact of shareholding ratios on performance.Originality/valueThe mixed-ownership reform of Chinese SOEs aims to optimize shareholding and control structures between state and nonstate shareholders. Therefore, research on the impact of nonstate shareholding ratios, control rights and shareholding–control matching on corporate performance is highly pertinent. However, existing studies have focused on the effects of single factors on performance, without exploration of the economic implications of shareholding–control matching. This study not only prioritizes the optimization of shareholding and control structures but also underscores the importance of granting nonstate shareholders control rights proportionate to their shareholding, providing critical evidence of the value of improving SOEs' ownership structure.
Construction of taxonomy of conceptualization of sustainability in improving the industrial production process
Authors: de Oliveira Neves Fábio , Salgado Eduardo Gomes , Ewbank Henrique , Sampaio Paulo 
Published: December 2023

PurposeIndustrialization is a major contributor to pollution and the worsening of some social problems. A change in this context would help in a new industrial model aiming at a viable and sustainable manufacturing system. This research aims to verify the state of the art of sustainability within the industrial production process through a systematic literature review, verifying the main characteristics in relation to industrial sustainability that the literature demonstrates.Design/methodology/approachThe development of the research took place in three stages: a survey of articles with Journal Citation Reports (JCR), the construction of the database and descriptive analysis and text mining analyses of social networks and content. The survey took place through academically endorsed research platforms, totaling a total of 352 scientific articles, which included 18 quality management tools and worked with at least one sustainability indicator (financial, social and environmental).FindingsLean manufacturing, integrated management system and Six Sigma were the most cited quality tools, and articles containing the three indicators were found more frequently. It was found that most authors treated sustainability only as an environmental contribution. Knowledge of the organization's structural and management issues is essential for implementing sustainability and production process improvement.Originality/valueThis work is the first to develop a systematic analysis regarding the use of sustainability implementation in the industrial production process, considering a wide scope of production process tools, guiding on the characteristics of sustainability relating to the main critical success factors (CSFs), motivations, difficulties and benefits that lead industries in different parts of the world to implement sustainability.