bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment and clinical outcomes of acute glomerulonephritis among children admitted to the pediatric ward, Asella Teaching and Referral Hospital, Arsi, Ethiopia
Authors: Demssie Solomon , Abay Tigist , Derso Yonas 
Published: October 2023

Abstract

Background
Acute glomerulonephritis is an acute kidney injury syndrome characterized by the sudden onset of edema and new-onset or worsening hypertension. It is common in school-aged children and typically presents with hematuria, edema, oliguria and varying degrees of renal insufficiency. This problem is particularly important in developing countries. Therefore, this study aimed to assess the treatment and clinical outcomes of AG among children admitted to the pediatric ward in Asella Teaching and Referral Hospital, Ethiopia.
Methods
A retrospective cross-sectional study design was conducted at the Asella Teaching and Referral Hospital pediatrics ward from September 2017 to June 2021. A simple random sampling technique was applied to select 282 study participants. Modified questionnaires based on a previous study were used to collect the data and then entered into Epi-info version 7.2.1.0 and exported to SPSS version 23 for further analysis.
Result
A total of two hundred eighty-two records of children diagnosed with acute glomerulonephritis were included in this study. The age range of the participating patients was 2 to 14 years. More affected patients were male. The most affected age group was between 6 and 10 years (55.3%). The most common clinical manifestation was facial edema (100%), and leg edema was 90.1%. The complications were hyperkalemia (10.6%), heart failure (9.9%) and anemia (9.2%). A total of 131 (92.9%) patients improved and were discharged within two weeks (positive outcome).
Conclusion
The highly affected age group was between 6 and 10 years, and most of the patients were admitted with different complications. Timely and proper intervention is necessary, and long-term follow-up should be performed in every patient.
Factors Influencing Interprofessional Collaboration in General and During Multidisciplinary Team Meetings in Long-term Care and Geriatric Rehabilitation: a Qualitative Study
Authors: Doornebosch Arno J. , Achterberg Wilco P. , Smaling Hanneke J.A. 
Published: October 2023

Abstract
Background Interprofessional collaboration is essential to respond to the growing complexity of care and to maintain high-quality care in long-term care and geriatric rehabilitation. However, little is known regarding factors perceived by the actors involved as influencing interprofessional collaboration in long-term care and geriatric rehabilitation. We therefore examined the facilitators of and barriers to interprofessional collaboration in general and during multidisciplinary team meetings specifically as mentioned by the actors involved, as well as the differences between long-term care and geriatric rehabilitation. Also investigated was whether, and if so which patient outcome measures are used in multidisciplinary team meetings.Methods Qualitative study using thematic analysis. Ten focus groups and 18 semi-structured interviews were held with 14 patients, 13 informal caregivers, and 22 healthcare professionals in eight long-term care and geriatric rehabilitation facilities across the Netherlands.Results The perceived influencing factors can be classified into two general themes: 1) ‘Involvement of patient, informal caregiver, and healthcare professional’, categorised into: ‘participation of patients and informal caregivers’, ‘behaviour and attitude of team members’, ‘expectations of team members towards each other’, and ‘exchange of information, knowledge, and reciprocity in communication’; and 2) ‘Methodical approach to providing care for older people’, consisting of: ‘coordination of team procedures’, and ‘coordination of organisational procedures’. Also, one specific theme for multidisciplinary team meetings was identified: ‘Involvement of patient, informal caregiver, and healthcare professional in multidisciplinary team meeting, categorised into: ‘team procedures’, ‘working methodically’, and ‘participation in multidisciplinary team meetings. Standardised patient outcome measures were not often used in multidisciplinary team meetings.Conclusion People involved in long-term care and geriatric rehabilitation indicated that, apart from working methodically, being involved in care and multidisciplinary team meetings are essential factors influencing interprofessional collaboration. These factors must be taken into consideration to provide valuable, high-quality care to older people residing in long-term care and geriatric rehabilitation through interprofessional collaboration.Trial registration Not applicable
Flexible Adaptive Sensing Tonometry for Medical-grade Multi-parametric Hemodynamic Monitoring
Authors: Pan Tingrui , Deng Mengkang , Du Chentao , Fang Jiayuan , Xu Changshun , Guo Chenhui , Huang Jiantao , Li Kang , Chen Lei , Zhang Yuan-Ting , Chang Yu 
Published: October 2023

Abstract

Continuous hemodynamic monitoring in a wearable means can play a crucial role in managing hypertension and preventing catastrophic cardiovascular events. In this study, we have described the first wearable tonometric device, referred to as flexible adaptive sensing tonometry (FAST), which is capable of continuous and accurate monitoring of hemodynamic parameters within the medical-grade precision. In particular, the FAST system integrates a 1×8 unit array of highly sensitive and highly flexible iontronic sensing (FITS) with 1mm spatial resolution and a closed-loop motion system. The flexible tonometric architecture has been used to determine the radial arterial position with high sensitivity and high conformability, which simplifies the biaxial searching process of the traditional applanation tonometry into a highly efficient uniaxial applanation while keeping the medical-precision assessments. Importantly, a self-calibration algorithm can be automatically implemented during the applanation process, from which the intra-arterial blood pressure wave can be continuously predicted within the medical-grade precision, and subsequently, multi-parametric hemodynamic analysis can be performed in real-time. Experimental validations on health volunteers have demonstrated that the FAST measurements are all within the required accuracy of the clinical standards for continuous pulse wave assessments, blood pressure monitoring as well as other key hemodynamic parameter evaluations. Therefore, the FAST system, by integrating the flexible iontronic sensing array, provides a real-time, medical-grade hemodynamic monitoring solution in a continuously wearable manner, from which remote patient-centered monitoring can be delivered with both medical precision and convenience.
Prevalence of neurodevelopmental disorders (NDDs) in looked after children (Lac) versus children that are not looked after (non-Lac) and adverse outcomes: A systematic review and Meta-analysis
Authors: Heady Nicola , Watkins Alan , John Ann , Hutchings Hayley 
Published: October 2023

Abstract
Background
Looked after children (Lac) continue to attain suboptimal health and social outcomes and have a high prevalence of mental, developmental and behavioural disorders. Limited in research is the exploration of neurodevelopmental disorders (NDDs) in this vulnerable population. This review aims to compare prevalence rates of NDDs in children who are looked after (Lac) versus children not looked after (non-Lac) and identify any impacts on Lac diagnosed with a NDD.
Methods
Articles were identified in PubMed, ASSIA, IBSS, Web of Science, PsychINFO, Scopus, Psych articles, Social Care Online. Studies that provided primary data on the prevalence of a ND for both Lac and non-Lac under the age of < 25 years were included. Two reviewers appraised the articles using the Joanna Briggs Institute critical appraisal tools. Risks ratio and 95% confidence intervals (CI) using the Mantel-Haenszel random-effects model were used to express and estimate the mean effect,
Results
Of a total 5,611 records, 12 studies met eligibility. Six studies that met inclusion criteria for a meta-analysis highlight how Attention-deficit hyperactivity disorder (ADHD) RR = 2.69 [1.44, 5.01] and autism spectrum disorder (ASD) RR = 2.23 [1.63, 3.05] have a higher prevalence in Lac compared to non-Lac. The remaining six studies that compared prevalence of NDDs but were not eligible for the meta-analysis are described as a narrative and highlight the adverse outcomes that effect the Lac with a NDD. Findings related to foster care placement, mental health service usage and medication, physical, emotional abuse and criminal justice involvement are discussed.
Conclusion
Results show that the prevalence of NDDs is higher in Lac versus non-Lac and propose that Lac with a NDD experience more adverse outcomes compared to their non-Lac peers with a NDD. More research is needed to explore the prevalence of NDDs in both populations and further investigate the adverse outcomes that may affect the Lac with a NDD.
Treatment Preferences and Experiences Among Patients With Postpartum Depression
Authors: Raines Christena , Saacks Cynthia B. , Chiang Tina H. , Devendorf Andrew R. , Prilliman Claudia , Stout Coy 
Published: October 2023

Abstract
Purpose To understand which treatment attributes postpartum depression (PPD) patients prefer and contribute to treatment selection.Methods An online survey was administered to 154 PPD patients to investigate the following treatment attributes: route of administration, dosing schedule, location where treatment is received/administered, most common side effects, and ability to breastfeed during treatment. The survey modeled the discrete choice experiment (DCE) methodology to ascertain treatment choices based on 4 blinded profiles: Profile A (investigational long-acting injectable), Profile B (currently available intravenous infusion administered over 60 hours in an in-patient setting), Profile C (investigational oral medication dosed over 14 days), and Profile D (a composite of commonly prescribed oral medications).Results The study sample’s mean age was 35.3 years, 24% had a history of multiple births, 27% had given cesarean delivery, and on average, received 2 PPD diagnoses by a healthcare professional. The DCE results showed that Profile D was preferred over others, primarily due to the route of administration and the ability to breastfeed concurrently. Profile B was least preferred, and there was no difference in preference between Profiles A and C. This study showed a preference for an orally administered medication profile; however, the long-acting injectable administered in a single office visit was preferred equally to the oral medication (Profile C), dosed over 14 days.Conclusions The results suggests that the route of administration and the ability to breastfeed concurrently are strong drivers for patient treatment choice and knowing what each patient prefers may help providers to tailor their care.
Simulated physicomechanical and Electrochemical Impedance Spectroscopy Assessment of Basalt Powder Waste Added to Portland Cement in Different Corrosive Media
Authors: Hashem Israa A. Abo , Gaber Ghalia A. , Ahmed Amal S. I. , Ghany Nabil A. Abdel 
Published: October 2023

Abstract
A basalt stone-crushing plant's byproduct is basalt powder. Proposing the use of these byproducts presents significant disposal, environmental pollution and health risk issues. Basalt can be employed as a novel mineral additive and had obvious potential for pozzolan activity. This study evaluated basalt powder's (BP) usage as a partial replacement (5, 10, 20%) of ordinary Portland cement (OPC) to enhance cement pastes properties. The conducted investigations were to ascertain physicomechanical properties and corrosion resistance using electrochemical impedance spectroscopy (EIS) of cement pastes with a partial addition of basalt powder in different solutions of 5% NaCl and 5% MgCl2 for up to 270 days. Infra-red spectroscopy (IR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDX) were also performed to investigate the hydration process and microstructure formation of the basalt blended paste. Results showed that replacing OPC with basalt powder improved the compressive strength of cement pastes. This is a result of the addition of basalt powder filler. The results of the BP20% specimen in 5% NaCl showed the highest values of Rp 953 ohms.cm2 after 270 days. This indicates high corrosion resistance as a result of binding by high Al2O3, which reduced free chloride in the solution. Furthermore, the decrease in iron rebar bonds in 5% MgCl2 compared to 5% NaCl showed a highly adherent protective layer developed on the surface of the rebar.
Individual, familial, community and health service factors associated with teenage pregnancy in Malawi: a community-based case-control study.
Authors: Kalulu James , Stones William 
Published: October 2023

Abstract
Background: Teenage pregnancies are a global concern. Malawi is one of the countries with the highest teenage pregnancy rates, with current teenage childbearing at 29%. There is a paucity of information on factors associated with pregnancy in Malawi. Therefore, this study aimed to identify individual, familial, community and health service level factors associated with teenage pregnancies in Malawi.
Methods: This was a community-based case‒control study that used secondary data from the 2015-16 Malawi Demographic and Health Survey from all 28 districts of Malawi. The study population comprised women aged 20 – 24 who participated in the survey. The study ran from September 2021 to October 2022 and used a sample size of 3,435 participants who were all women aged 20 – 24 in the dataset who met the inclusion criteria. Data were analysed using Stata 16 software. Logistic regression analyses were used to determine factors. Variables with a P value of < 0.1 in the univariate analysis were included in the multivariate analyses, where statistical significance was obtained at a P value < 0. 05.
Results: Data on 3435 participants were analysed. In multivariate analyses: no teenage marriage (p <0.001); secondary education (p < 0.001); higher education (p < 0.001); richest category of wealth index (p = 0.004), use of contraception (p = 0.001) under individual factors and domestic violence by father or mother (p = 0.001) under familial level factors were found to be significant factors.
Conclusion: This study found that teenage pregnancy is associated with individual and familial factors. The government has to sustain and expand initiatives that increase protection from teenage pregnancy, reinforce the implementation of amended marriage legislation, introduce policies to improve the socioeconomic status of vulnerable girls and increase contraceptive use among adolescent girls before their first pregnancy. Further research is also recommended to resolve inconclusive results.
Higher SARS-CoV-2 antibody response following infection in children compared to adult members of the same family
Authors: Mentor Girlande , Farrar Daniel S. , Chiara Costanza , Dufour Mi-Suk Kang , Valois Silvie , Taillefer Suzanne , Drouin Olivier , Renaud Christian , Kakkar Fatima 
Published: October 2023

Abstract
Background
While children have had less severe clinical disease after SARS-CoV-2 infection (COVID-19), the cause of this remains unclear. The objective of this study was to describe the humoral immune response to COVID-19 in children vs. adult household contacts, and to identify predictors of the response over time.
Methods
Prospective cohort study of children with COVID-19 and their families at the Centre Hospitalier Universitaire Sainte-Justine (CHUSJ) in Montreal, Quebec, Canada, between August 2020 and July 2021. Children with a positive SARS-CoV-2 polymerase chain reaction (PCR) test (index case) were recruited along with their household contacts. Serum IgG antibodies against SARS-CoV-2 S1/S2 spike proteins were compared between children and adults at 6- and 12-months after infection.
RESULTS
132 participants were enrolled, this included 54 index cases (children) and 78 household contacts from 36 families. Median SARS-CoV-2 antibody titer at 6 months post-infection was significantly higher in children vs. adults (92.7 AU/ml 23.8 AU/ml, p = 0.004). Significant predictors of lack of SARS-CoV-2 seropositivity were age ≥ 25 vs. <12 years (odds ratio [OR] = 0.23, p = 0.04), presence of comorbidities (vs. no adjusted OR = 0.23, p = 0.03), and immunosuppression (vs. immunocompetent, adjusted OR = 0.17, p = 0.02). While there were differences in the magnitude of median antibody titers by family, within families, children consistently had a higher antibody titer than adults.
CONCLUSION
Children produced a stronger humoral (anti-S1/S2 spike IgG) response to natural SARS-CoV-2 infection than their adult household contacts. These data reinforce the differences in the clinical and immunological responses to SARS-CoV-2 infection between children vs. adults.
Food passage following proximal gastrectomy with double-tract reconstruction and its effect on nutritional status in early gastric cancer
Authors: Park Ji Yeon , Park Ki Bum , Lee Seung Soo , Chung Ho Young , Jeong Shin Young , Lee Sang-Woo , Kwon Oh Kyoung 
Published: October 2023

Abstract
This study aimed to investigate the food passage patterns following laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) and its effect on nutritional outcomes up to 1 year in patients with upper-third gastric cancer. Ten patients with early gastric cancer scheduled for LPG-DTR were enrolled in this prospective cohort study, with data collected over 12 months. Liquid and solid food transits were evaluated with fluoroscopic upper gastrointestinal study and radionuclide scintigraphy, respectively. The findings revealed that the serum vitamin B12 levels initially decreased but recovered to the baseline level within 12 months. Patients lost 14.5% ± 3.6% of their initial bodyweight. The main passage routes between liquid and solid foods were different, which was mainly via the interposed jejunum in liquid contents, whereas via both tracts following solid food intake. The median half-life of solid food emptying from the remnant distal stomach was 105.1 minutes, and duodenal passage of solid food was noted in 9 of 10 patients. In conclusion, LPG-DTR demonstrated varying food passage patterns depending on the food contents. The emptying of solid food from the remnant stomach through the pyloric ring was considerably delayed, which could be related to the ineffective prevention of weight loss.
Comparing the results of human chorionic gonadotropin and dual triggering protocols in consecutive IVF cycles of women with poor ovarian response: A retrospective case-control study.
Authors: YAZICI MELIS GOKCE KOCER , Ozkara Gulcin , Yesiladali Mert , Caglar Ece Gumusoglu , Algoz Oya , Attar Erkut 
Published: October 2023

Abstract
Purpose
Bolus administration of GnRH analogs mimics physiological ovulation and adding GnRH-a to hCG (“dual triggering”) to induce final oocyte maturation stimulates the luteinizing hormone surge which improves IVF outcomes by decreasing immature oocyte rates. Effects of dual triggering on oocytes have been investigated in previous studies. However, retrieved oocytes in consecutive hCG and dual triggering cycles of poor responder(POR) patients has not been studied yet. In this study, we aimed to examine the retrieved/mature oocyte counts after administering hCG and dual triggering to POR patients in their consecutive IVF cycles.
Method
A total of 54 patients with two consecutive cycles within two years were included into this single-centered, retrospective cohort study that was conducted at Yeditepe University Hospitals, Istanbul, Turkey, between 2014 and 2021. All patients were diagnosed with POR according to the Bologna Criteria (2011). Dual vs hCG triggering protocols were compared using Wilcoxon test in terms of oocyte count and maturation.
Results
Although a statistically significant difference was observed between the ages of patients in their consecutive IVF cycles, it did not have a clinical significance (38.80±3.72 vs 38.17±3.75, p<0.001). Anti mullerian hormone levels and body mass indexes, basal follicle stimulating hormone and estradiol levels were similar between two cycles (p>0.05). No statistically significant difference was found in terms of total and mature oocytes between two protocols.
Conclusion
The results demonstrated that the choice of triggering method, whether hCG or dual triggering, did not significantly influence neither the retrieved oocyte count nor maturation in POR patients.
Genome-wide identification, Expression Profiling, and Protein Interaction Analysis of the CCoAOMT Gene Family in the Tea Plant (Camellia sinensis)
Authors: Wang Yiqing , Wang Tao , Qi Siyu , Zhao Jiamin , Kong Jiumei , Xue Zhihui , Sun Weijiang , Zeng Wen 
Published: October 2023

Abstract
Background
The caffeoyl-CoA-O methyltransferase (CCoAOMT) family is a key enzyme in the oxidative methylation of phenolic substances and is involved in many plant processes, such as growth, development, and stress response. However, the interactions between CCoAOMT protein members in tea plants are limited.
Results
In this study, 10 CsCCoAOMT members with conserved gene structures and motifs were identified based on the genome of Camellia sinensis (cultivar ‘HuangDan’). CsCCoAOMT was located on six different chromosomes (1, 2, 3, 4, 6, and 14). The phylogenetic relationship divided CsCCoAOMT into two groups, including I and II, the CsCCoAOMT of Ia was identified as likely to include candidate genes involved in lignin biosynthesis. In addition, the CsCCoAOMT family member protein interaction networks established by the yeast two-hybrid (Y2H) assay showed 9 pairs of members with interaction relationships.
Conclusions
We identified the CCoAOMT gene family in Camellia sinensis and systematically investigated their classifications, phylogenetic and synteny relationships, gene structures, protein interactions, tissue-specific, and stresses-responsive expression patterns. Our results will provide insights into the evolution and composition of CsCCoAOMT, the CCoAOMT interaction found in this study suggests the potential formation of the O-methyltransferase (OMT) complex in the methylation modification process, which may extend our knowledge of this gene family’s functions in diverse biological processes.