bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of attending rehabilitation after traumatic knee joint injury on femoral articular cartilage morphology in collegiate rugby players with a history of intracapsular knee joint injury during two-year consecutive rugby seasons
Authors: Hori Miyuki , Terada Masafumi , Suga Tadashi , Isaka Tadao 
Published: January 2024

IntroductionThis present study aimed to compare ultrasonographic measures of femoral articular cartilage during two-year seasons between collegiate rugby players who have attended supervised rehabilitation following intracapsular knee joint injury and those without a history of knee injury.MethodsUsing a prospective observational study design, 12 male collegiate rugby players with a previous history of intracapsular knee joint injury who have received and completed supervised rehabilitation following their injury and 44 players without knee joint injury participated in this study. Ultrasonographic images were used to verify changes in femoral articular cartilage thickness and cross-sectional area (CSA) with or without a previous history of knee joint injury over two consecutive rugby seasons.ResultsSignificant time main effects were observed for the lateral condylar thickness (p &lt; 0.001), the intercondylar thickness (p = 0.001), the medial condylar thickness (p &lt; 0.001), and CSA (p &lt; 0.001). No significant interactions nor group main effects were identified for all femoral articular cartilage (p &lt; 0.05).ConclusionsCollegiate rugby players demonstrated a decrease in femoral articular cartilage thickness and CSA over two-year consecutive rugby seasons. These findings indicate that engaging in collegiate rugby induces alterations in femoral articular cartilage structure. Furthermore, there were no differences in all femoral cartilage outcome measures between rugby players with and without a previous history of traumatic knee joint injury. Therefore, attending supervised rehabilitation at the time of their knee joint injury appeared to reduce the impact of a previous history of intracapsular knee joint injury on the change in femoral articular cartilage thickness and CSA among active rugby players.
Short-term outcomes of robotic vs. laparoscopic surgery for rectal cancer after neoadjuvant therapy: a meta-analysis
Authors: Zhang Yuqiang , Dong Bo , Li Guanglin , Ye Wei 
Published: January 2024

BackgroundThe effect of robotic surgery (RS) for rectal cancer after neoadjuvant therapy is still controversial, and a comprehensive search and analysis of the current relevant evidence is necessary. Our study aimed to evaluate the efficacy of RS for rectal cancer after neoadjuvant therapy compared with conventional laparoscopic surgery (LS).MethodsUp to August 23, 2023, Embase, PubMed, Web of Science, and Cochrane databases were searched for studies of RS for rectal cancer after neoadjuvant therapy. Odds ratio (OR) or mean difference (MD) was used to calculate the effect sizes using RevMan 5.3.ResultsA total of 12 studies reporting on 11,686 participants were included. Compared with LS, RS increased the operative time (MD 35.16 min; 95% CI: 16.24, 54.07), but it did significantly reduce the risk of the conversion to open surgery (OR 0.46, 95% CI 0.40, 0.53) and improved the TME incomplete rate (OR 0.40, 95% CI 0.17, 0.93). Moreover, there were no difference in total postoperative complications (OR 1.13, 95% CI 0.84, 1.52), circumferential resection margin positivity (OR 0.90, 95% CI 0.63, 1.27), distal margin positive (OR 0.60, 95% CI 0.29, 1.22), blood loss (MD −11.57 ml; 95% CI: −39.09, 15.94), length of hospital stay (MD −0.08 days; 95% CI: −1.26, 1.10), mortality (OR 0.59, 95% CI 0.29, 1.21), lymph node harvested (MD 0.69.; 95% CI: −0.43, 1.82), and the time of first flatus (MD −0.47 days; 95% CI: −1.19, 0.25) between the two groups.ConclusionsRS was associated with superiority over LS in reducing the risk of the conversion to open surgery and improving TME incomplete rate, which suggested that RS could be an effective method for treating rectal cancer after neoadjuvant therapy.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=460084, PROSPERO (CRD42023460084).
Outcomes in dogs undergoing surgical stabilization and non-stereotactic radiation therapy for axial and appendicular bone tumors
Authors: Griffin Maureen A. , Mastorakis Andrea , Wustefeld-Janssens Brandan , Martin Tiffany Wormhoudt , Duda Lili , Seguin Bernard , Tremolada Giovanni 
Published: January 2024

BackgroundInformation on dogs that undergo radiation therapy (RT) with non-stereotactic protocols in addition to surgical stabilization with implant placement for treatment of bone tumors is limited.ObjectiveOur primary objectives were to describe the clinical characteristics as well as short- and long-term outcomes, including complications, function, and disease progression, in dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor.MethodsA bi-institutional retrospective case series was performed.AnimalsEight client-owned dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor were included.ResultsTumor types included osteosarcoma or suspected osteosarcoma (5), plasma cell tumor (2), and grade 3 fibrosarcoma (1). Radiation protocols were hypofractionated (palliative intent) in 5 dogs and fractionated (definitive intent) in 3 dogs. Five dogs experienced complications following both RT and surgery, including grade 1 complications in two dogs, a grade 2 complication in one dog, both grade 1 and 2 complications in one dog, and both grade 2 and 3 complications in one dog. Clinical signs subjectively improved in all dogs that had outcomes relative to function documented post-surgery/RT (7). Of these 7 dogs, 4 maintained long-term improvement in function and clinical signs, whereas 3 experienced subsequent recurrence/progression of clinical signs at a median of 133 days (range 91-186) postoperatively in association with biomechanical complications (screw loosening), surgical site infection, and local disease progression in 1 dog each; subsequent treatment resulted in improved clinical signs for each of these 3 dogs, such that overall good long-term functional outcomes were experienced. No dogs required amputation or additional vertebral surgery as salvage for local disease control or palliation. The median progression free interval was 206 days (range 25-1078), and the median survival time was 253 days (range 122-1078) with 1 additional dog lost to follow-up at 575 days. Two dogs experienced local disease progression, and 6 dogs experienced systemic disease progression; both dogs that developed local disease progression received palliative intent RT protocols.Clinical relevanceIn this cohort, dogs with primary bone tumors that underwent surgical stabilization with implant placement and hypofractionated or fractionated non-stereotactic RT for local treatment had a low incidence of major complications, good limb function and ambulation post-treatment, and relatively prolonged survival times despite disease progression.
Feeding spray-dried plasma to broilers early in life improved their intestinal development, immunity and performance irrespective of mycotoxins in feed
Authors: Gómez-Verduzco Gabriela , Arce-Menocal José , López-Coello Carlos , Avila-González Ernesto , Márquez-Mota Claudia C. , Polo Javier , Rangel Luis 
Published: January 2024

IntroductionFungi that produce mycotoxins can grow on certain food products, such as grains and feed, and can cause a variety of health issues if consumed by animals, including chickens. The use of spray-dried plasma (SDP) is one strategy for combating the health problems caused by mycotoxins.Materials and methodsIn the present study, Ross 308 chickens (n = 960) were divided into four treatment groups. T1 group was given a control diet (corn–soybean meal), T2 group was given a control diet +2% SDP, T3 group was given a control diet +2% SDP + mixture mycotoxins and T4 group was givena control diet + mycotoxin mixture.ResultsThe presence of SDP resulted in weight gain and decreased feed efficiency, whereas mycotoxins resulted in weight loss and increased feed efficiency. SDP increased the thymus’ relative weight. The presence of mycotoxins increased the heterophile/lymphocyte ratio. The presence of mycotoxins reduced the production of IL-2 and macrophage inflammatory protein-3 Alpha (MIP-3a), whereas the presence of SDP increased the production of macrophage colony-stimulating Factor (M-CSF). SDP resulted in higher IgA concentrations in the intestinal and tracheal washes than mycotoxin. Finally, adding SDP to broiler diets boosts weight gain, feed efficiency, and immune system development.DiscussionOur results provide information supporting that SDP is a promising tool for improving poultry immunity and performance.
Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence
Authors: Ahuja Kriti , Batra Vipul , Kumar Rakesh , Datta Tirtha Kumar 
Published: January 2024

IntroductionOne of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present study was undertaken to modulate the canonical Wnt (Wingless/integration) signaling pathway in the poor-quality (colorless cytoplasm after Brilliant Cresyl Blue staining, BCB-) buffalo cumulus-oocyte complexes (COCs) to improve their in vitro maturation (IVM) and embryo production (IVEP) rates.MethodsThe expression of key Wnt pathway genes was initially assessed in the good (blue cytoplasm after Brilliant Cresyl Blue staining, BCB+) and poor quality (BCB-) buffalo COCs to establish a differential activity of the Wnt pathway. The BCB- COCs were supplemented with the Wnt pathway inhibitor, Dickkopf-related protein 1 (DKK1) and later subjected to IVM and IVEP along with the BCB+ and BCB- controls. The cumulus expansion index (CEI), rate of nuclear maturation (mean percentage of oocytes in the MII stage) and embryo production, and the expression of developmentally important genes were evaluated to assess the effect of Wnt pathway inhibition on the development competence of these poor-quality oocytes.ResultsThe Wnt pathway genes exhibited a significantly higher expression (p &lt; 0.05) in the poor-quality BCB- oocytes compared to the good-quality BCB+ oocytes during the early maturation stages. The supplementation of BCB- COCs with 100 ng/mL DKK1 effectively inhibited the expression of the key mediators of the Wnt pathway (β-catenin and dishevelled homolog 1, DVL1). DKK1 supplemented BCB- COCs exhibited significantly improved cytoplasmic and nuclear maturation indices, development rates and significantly elevated expression (p &lt; 0.05) of genes implicated in germinal vesicle breakdown (GVBD) and embryonic genome activation (EGA) vis-à-vis BCB- control COCs.ConclusionThese data indicate that inhibition of the Wnt pathway during the initial course of oocyte maturation can improve the development competence of poor-quality buffalo oocytes.
Towards a Timepix3 Radiation Monitor for the Accelerator Mixed Radiation Field: Characterisation with Protons and Alphas from 0.6 MeV to 5.6 MeV
Authors: Prelipcean Daniel , Lerner Giuseppe , Slipukhin Ivan , Lucsanyi David , Sandberg Hampus , Storey James , Martin-Holgado Pedro , Romero-Maestre Amor , Morilla García Yolanda , García Alía Rubén 
Published: January 2024

A Timepix3 detector with a 300 μm silicon sensor has been studied as a novel radiation monitor for the mixed radiation field at the Large Hadron Collider at CERN. This work describes a test campaign carried out at Centro Nacional de Aceleradores with quasi-mono energetic protons (alphas) from 0.6 (1) to 5 (5.6) MeV, where orthogonal irradiations are used to obtain an energy calibration, and a low-energy angular scan to estimate the front dead layer thickness of the sensor. The detector is operated in hole collection mode and at a partial bias of 250 μm at 50 V, which increases the charge sharing among pixels to mitigate the signal saturation at high energy depositions. The data, supported by FLUKA Monte Carlo simulations of energy losses in the sensor, show that the Timepix3 monitor operates in a linear regime up to energy depositions of around 600 keV per pixel and 2 MeV per cluster. As a result, the detector has been found to be suitable for measuring charged particle fluxes in the LHC mixed radiation field within the linear calibration regime, with the partial exception of inelastic nuclear reaction hits (mostly from neutrons).
On the Properties of a Newly Susceptible, Non-Seriously Infected, Hospitalized, and Recovered Subpopulation Epidemic Model
Authors: Legarreta Carmen , De la Sen Manuel , Alonso-Quesada Santiago 
Published: January 2024

The COVID-19 outbreak has brought to the forefront the importance of predicting and controlling an epidemic outbreak with policies such as vaccination or reducing social contacts. This paper studies an SIHR epidemic model characterized by susceptible (S), non-seriously infected (I), hospitalized (H), and recovered (R) subpopulations, and dynamic vaccination; vaccination itself and H are fed back, and its dynamics are also determined by a free-design time-dependent function and parameters. From a theoretical analysis, the well-posedness of the model is demonstrated; positivity and the disease-free (Pdf) and endemic (Pee) equilibrium points are analyzed. The controlled reproduction number (Rc) is proved to be a threshold for the local asymptotic stability of Pdf and the existence Pee; when Rc<1 (Rc>1), then Pdf is (not) locally asymptotically stable and Pee does not (does) exist. Simulations have been carried out with data concerning COVID-19 where the importance of keeping Rc<1 to prevent the disease spreading and future deaths is highlighted. We design the control input, since it can be easily adapted to match the user specification, to obtain impulsive and regular vaccination and fulfill the condition Rc<1.
Analisis Pengaruh Enterprise Risk Management Terhadap Firm Value Bagi Perusahaan Menerapkan ERP
Authors: Dewi Rahma , Asniati Bahari  
Published: January 2024

Penelitian ini bertujuan untuk mengetahui secara empiris pengaruh Enterprise Risk Management (ERM) terhadap firm value bagi perusahaan yang menerapkan Enterprise Resource Planning (ERP) pada perusahaan barang baku dan perindustrian. Variabel dependen dalam penelitian ini ialah firm value dan ERM sebagai variabel independen. Objek penelitian ialah perusahaan barang baku dan perindustrian yang terdaftar di Bursa Efek Indonesia (BEI) periode 2019-2021. Populasi penelitian berjumlah 132 perusahaan dengan teknik pengambilan sampel menggunakan pursosive sampling. Pendekatan penelitian yang digunakan yaitu pendekatan kuantitatif. Teknik analisis data menggunakan model regresi linier sederhana. Penelitian ini menggunakan data sekunder yang mana firm falue diukur menggunakan Tobins Q yang dilihat dari laporan keuangan dan komponen ERM dilihat dari pengungkapan manajemen risiko didalam laporan tahunan. Pengolahan data menggunakan program SPSS versi 26. Temuan dalam penelitian ini menunjukkan bahwa ERM berpengaruh positif dan signifikan terhadap firm value pada perusahaan barang baku dan perindustrian yang menerapkan ERP dan terdaftar di BEI periode 2019-2021.
Penelitian ini bertujuan untuk mengetahui secara empiris pengaruh Enterprise Risk Management (ERM) terhadap nilai perusahaan pada perusahaan yang menerapkan Enterprise Resource Planning (ERP) pada perusahaan industri dan barang mentah. Variabel dependen dalam penelitian ini adalah nilai perusahaan dan ERM sebagai variabel independen. Objek penelitian adalah perusahaan barang mentah dan industri yang terdaftar di Bursa Efek Indonesia (BEI) periode 2019-2021. Populasi penelitian berjumlah 132 perusahaan dengan teknik pengambilan sampel pursosive sampling. Pendekatan penelitian yang digunakan adalah pendekatan kuantitatif. Teknik analisis data menggunakan model regresi linier sederhana. Penelitian ini menggunakan data sekunder dimana nilai perusahaan diukur dengan menggunakan Tobin's Q dilihat dari laporan keuangan dan komponen ERM dilihat dari pengungkapan manajemen risiko pada laporan tahunan.
MANAJEMEN PPKn DI SEKOLAH MENENGAH
Authors: Mulyadi Yahya 
Published: January 2024

PPKn merupakan salah satu mata pelajaran di sekolah berdasarkan Kurikulum 2013 yang saat ini berlaku.Â Sebagai mata pelajaran wajib, PPKn harus ditempuh oleh semua siswa. Guru PPKn memiliki peranan dominan dalam merekayasa pembelajaran untuk mencapai tujuan PPKn. Secara kurikuler PPKn memiliki tujuan membentuk siswa menjadi warga negara dan warga dunia yang baik.Guru PPKn dituntut untuk menjalankan manajemen PPKn dengan baik dan benar. Manajemen PPKn adalah urusan aktualisasi fungsi-fungsi manajemen yang meliputi perencanaan, pelaksanaan, dan evaluasi. Dalam perencanaan, guru PPKn adalah pengembang kurikulum nasional menjadi kurikulum operasional untuk siswa dan kelasnya masing-masing. Kurikulum operasional sebagai rencana pelajaran dilaksanakan melalui proses (kegiatan) belajar-mengajar alias pembelajaran. Evaluasi atau penilaian adalah proses menentukan nilai dan makna keberhasilan PPKn berdasarkan standar yang ditetapkan, tidak hanya mengenai hasil belajar siswa tetapi juga melihat efektifitas proses belajar-mengajar dan kelayakan rencana pelajaran.Â Kurikulum 2013 menuntut guru PPKn untuk menerapkan Pendekatan Saintifik dalam pembelajaran dan menggunakan Pendekatan Otentik untuk mengetahui hasil belajar siswa.Â Kata kunci: Â Â Kurikulum PPKn 2013, kurikulum nasional, kurikulum operasional, warga negara dan warga dunia yang baik, manajemen PPKn, pendekatan saintifik, penilaian otentik.
PENDIDIKAN MULTIKULTURALISME SEBAGAI RESOLUSI KONFLIK : PERSPEKTIF PENDIDIKAN KEWARGANEGARAAN
Authors: Zulkifli Zulkifli , Maftuh Bunyamin , Malihah Elly 
Published: January 2024

Multikulturalisme merupakan salah satu realitas utama yang dimiliki oleh bangsa di Indonesia. Multikulturalisme dapat diartikan bahwa negara memberikan pengakuan adanya keragaman atau kemajemukan pada masyarakatnya. Adanya keragaman ini mestinya menjadi dasar bagi pendidikan yang berkeadaban. Multikulturalisme menjadi landasan budaya bagi kewargaan, kewarganegaraan, dan pendidikan. Resolusi konflikÂ yang menekankan pendidikan multikulturalisme dalam Pendidikan Kewarganegaraan dipandang memiliki urgensi yang penting karena secara historis bangsa ini telah melewati konflik karena budaya yang cukup pahit. Pendidikan apa pun bentuknya, tidak boleh kehilangan dimensi multikulturalnya, termasuk di dalamnya pendidikan kewarganegaraan, karena realitas dalam kehidupan pada hakikatnya bersifat multidimensional. Demikian juga halnya manusia sendiri pada hakikatnya adalah sebagai makhluk yang multidimensional. Karena itu, pendekatan kepada manusia dan untuk mengatasi problem kemanusiaan yang ada, tidak bisa lain kecuali dengan menggunakan pendekatan yang multidimensional dan di dalamnya adalah pendidikan multikultural. Pendidikan kewarganegaraan untuk Indonesia, secara filosofik dan substantif-pedagogis/andragogis, merupakan pendidikan untuk memfasilitasi perkembangan pribadi peserta didik agar menjadi warga negara Indonesia yang religius, berkeadaban, berjiwa persatuan Indonesia, demokratis dan bertanggung jawab, dan berkeadilan, serta mampu hidup secara harmonis dalam konteks multikulturalime-bhinneka tunggal ika. Perlu dikembangkan budaya kewarganegaraan Indonesia yang multikultural, yang berintikan â€œcivic virtueâ€ atau kebajikan atau akhlak kewarganegaraan. Kabajikan itu sepenuhnya harus terpancar dari nilai-nilai Pancasila yang secara substantif mencakup keterlibatan aktif warganegara, hubungan kesejajaran/egaliter, saling percaya dan toleran, kehidupan yang kooperatif, solidaritas, dan semangat kemasyarakatan multikultural. Semua unsur akhlak kewarganegaraan itu diyakini akan saling memupuk dengan kehidupan â€œcivic communityâ€ atau â€œcivil societyâ€ atau masyarakat madani yang multikultural berdasarkan Pancasila.Â
PERANAN PENDIDIKAN POLITIK dalam MATA PELAJARAN PPKN terhadap TINGKAT PARTISIPASI POLITIK SISWA di MADRASAH ALIYAH NEGERI (MAN) 2 CIANJUR
Authors: Wijaya Kevin Alexander , Mulyadi Yahya , Suhendar Ilham Fajar 
Published: January 2024

Pendidikan Politik dapat diartikan sebagai proses mempengaruhi individu agar dia bisa memperoleh informasi lebih lengkap tentang politik.Â Pendidikan politik itu perlu diberikan kepada siswa sejak dini karena mereka yang akan menjadi generasi penerus dan yang akan memberikan suara di masa depan. Penelitian ini merupakan penelitian deskripsi dengan menggunakan pendekatan kuantitatif.Dalam mengumpulkan data dan informasi yang diperlukan dalam penelitian ini, peneliti menggunakan teknik penelitian melalui angket, wawancara, dan studi dokumentasi yang bersumber dari siswa dan guru sebagai responden. Populasi penelitian ini yaitu siswa kelas 11 MIA, Guru PPKn dan pembina OSIS masing-masing satu orang, ketua OSIS, ketua kelas XI MIA berjumlah 5 orang, wali kelas XI MIA berjumlah 3 orang, dan perwakilan siswa dari tiap kelas masing-masing berjumlah satu orang. Sampel penelitian ini yaitu 25 orang dari tiap masing-masing kelas yang berjumlah 5 orang dari tiap kelasnya. Hasil penelitian menunjukan bahwa pendidikan politik dalam mata pelajaran PPKn berpengaruh terhadap tingkat partisipasi politik siswa disekolah karena selalu diadakan pembinaan sikap positif dan pendampingan oleh wali kelas dan dalam pelaksanaan kegiatan politik serta guru PPKn dalam kegiatan pembelajaran memberikan materi tentang politik. Partisipasi Politik tidak hanya dipraktikan dilingkungan berbangsa dan negara saja, melainkan bisa dipraktikan di lingkungan sekolah. Karena dilingkungan sekolah siswa sudah diajarkan tentang demokrasi, karena demokrasi dan partisipasi politik itu tidak dapat dipisahkan.
PEGARUH MINAT BELAJAR TERHADAP PRESTASI BELAJAR SISWA PADA MATA PELAJARAN PENDIDIKAN KEWARGANEGARAAN KELAS VIII DI SMP NEGERI 3 CIANJUR
Authors: Sopyana Rena 
Published: January 2024

Proses pembelajaran dapat terlaksana dengan baik apabila didukung oleh kegiatan pembelajaran yang efektif, kegiatan pembelajaran tersebut tentu tidak lepas dari cara siswa memperhatikan materi pelajaran yang disampaikan guru, minat belajar merupakan salah satu faktor penunjang siswa dalam kegiatan pembelajaran karena dengan minat belajar siswa dapat mengikuti pembelajaran dengan sebaik-baiknya, sehingga hasil belajar siswa berada pada tingkat yang optimal. Penelitian ini bertujuan untuk mengetahui pengaruh minat belajar terhadap prestasi belajar siswa pada mata pelajaran pendidikan kewarganegaraan kelas VIII di SMP Negeri 3 Cianjur. Hipotesis yang diajukan yaitu terdapat pengaruh positif dari minat belajar siswa terhadap prestasi belajar pada mata pelajaran pendidikan kewarganegaraan kelas VIII di SMP Negeri 3 Cianjur. Metode penelitian yang digunakan adalah metode deskriptif analitik, dengan teknik yang dipakai adalah angket, observasi, dan wawancara. Populasi yang dijadikan subjek dalam penelitian yaitu seluruh murid kelas VIII SMP Negeri 3 Cianjur berjumlah 270 orang siswa, serta sampel sejumlah 20%Â yaitu 45 orang.Dari hasil penelitian di SMP Negeri 3 Cianjur diperoleh temuan bahwa minat belajar berpengaruh positif terhadap prestasi belajar siswa pada mata pelajaran pendidikan kewarganegaraan, khususnya dalam peningkatan nilai ulangan harian, nilai ulangan tengah semester dan nilai ulangan akhir semester.