bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional intelligence and happiness in clinical medical students: A cross‐sectional multicenter study
Authors: Hatamnejad Mohammad Reza , Hosseinpour Morteza , Shiati Samin , Seifaee Asal , Sayari Mohammad , Seyyedi Faranak , Lankarani Kamran Bagheri , Ghahramani Sulmaz 
Published: December 2023

AbstractBackground and AimsEmotional intelligence (EI) has improved job performance and has been associated with the success of individuals. The interfering role of happiness in this equation is unneglectable; however, this association has not been established in clinical medical students exposed to work pressures and stressful hospital atmospheric. The present perusal was conducted to evaluate the relationship between EI and happiness in clinical medical students.MethodsA multicenter cross‐sectional investigation was conducted in Iran from December 2021 to June 2022. Multi‐stage cluster sampling followed by a systematic random selection was applied to choose participants. Data gathering was carried out online by Brief Emotional Intelligence Scale‐10 and Oxford Happiness Questionnaire.ResultsData from 405 participants were analyzed. The mean age was 24.2 years; men and women constituted 208 (51.4%) and 197 (48.6%) of all participants. Gamma regression analysis has determined age (Exp (B) = 1.016, p‐value < 0.001), female gender (Exp (B) = 0.966, p‐value = 0.04), extrovert personality (Exp (B) = 1.076, p‐value < 0.001), perceived somatic health (Exp (B) = 1.002, p‐value < 0.001), and stress level (Exp (B) = 0.990, p‐value = 0.01) as predictors of happiness. EI comprises five domains, and except for appraisal of others' emotions, an increase in all other domains of emotional intelligence was associated with higher happiness. GBRT model of significant variables revealed regulation of own emotions is the most happiness‐predictor variable (Exp (B) = 1.042, p‐value < 0.001).ConclusionDiminishing the stresses helps medical students have a happier life. In happiness‐boosting strategies, vulnerable individuals (women, introverts, and those of higher age) ought to be noted as the targeted population. In this investigation, emotional intelligence was the most effective predictor of happiness in clinical medical students. Planning to promote happiness in these medical staff by enhancing their EI leads to better decision‐making and more prosperity in their job, resulting in better patient care services.
Hepatitis B immunization strategies and its associated factors: A narrative review
Authors: Obeagu Emmanuel Ifeanyi 
Published: December 2023

AbstractBackgroundHepatitis B is a major public health concern as one third of the world's population is infected with hepatitis B virus (HBV). The risk of HBV infection remains primarily through percutaneous or mucosal contact with infected blood or body fluids.AimTo update the society on hepatitis B immunization strategies and its associated factors.Materials and MethodsThe review paper utilized different search engines such as Pubmed Central, Scopus, Web of Science, Google Scholar, and so on to conduct this review paper.ResultsImproving immunity through general vaccination recommendations has reduced the number of chronic hepatitis B cases among children and adolescents, but an influx of infections from endemic countries has increased the number of chronically infected adults. This is due to immigration from endemic countries to Hepatitis less burden areas like developed countries. Introduction of infant immunization programs in some countries has reportedly reduced the prevalence of HBV infection and reduced the incidence of liver cancer in children and young adults.ConclusionWhile hepatitis B vaccination coverage is low, a significant number of people are not adhering to full hepatitis B vaccination posing a potential hazard to health.
Screening and treatment of iron deficiency anemia in pregnancy: A review and appraisal of current international guidelines
Authors: O'Toole Fiona , Sheane Rachel , Reynaud Niamh , McAuliffe Fionnuala M. , Walsh Jennifer M. 
Published: December 2023

AbstractIron deficiency anemia (IDA) in pregnancy is a common diagnosis that is associated with adverse obstetric and neonatal outcomes. There remains uncertainty regarding how best to screen for, prevent, and treat established IDA in pregnancy. There is no consensus on the benefits of routine iron supplementation in pregnancy, with concerns regarding potential harmful effects of routine iron supplementation in women who are iron replete. Fourteen international guidelines were selected and appraised and compared by a multidisciplinary team. The AGREE II GRS tool was used. Each reviewer independently made their own assessment, and the scores from 1 to 7 were also collated and averaged for an overall score incorporating seven domains: process of development, clarity of presentation, completeness of reporting, clinical validity, and overall quality. The reviewers' scores were also individually compared according to discipline. The mean score across all the guidelines was 4.4 (range 3.5–6.5). Only half of the guidelines recommend routine iron in pregnancy. In terms of screening recommendations, five guidelines recommend screening with ferritin in addition to a full blood count in pregnancy, two recommend selective screening with ferritin for at risk groups only, and one guideline suggests using ferritin where feasible. Although many of the guidelines recommend similar doses of oral elemental iron of 100–200 mg daily for the treatment of established IDA in pregnancy, two recommend twice or three times daily dosing. Only five guidelines give hemoglobin rises to expect within specific timeframes. There remains a need to clarify the optimal screening method, dosing regimen, timing, and route of iron supplementation in pregnancy. Robust randomized controlled data are needed to guide appropriate prevention and management.
Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy‐epispadias complex
Authors: Morikawa Toshiharu , Iwatsuki Shoichiro , Naiki‐Ito Aya , Gonda Masakazu , Taguchi Kazumi , Naiki Taku , Hamamoto Shuzo , Okada Atsushi , Yasui Takahiro 
Published: December 2023

IntroductionThe bladder exstrophy‐epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment.Case presentationWe report the case of a 44‐year‐old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy‐epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment.ConclusionThis is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy‐epispadias complex.
Mutating Escherichia coli caused multiple organ dysfunction syndrome
Authors: Qi Lihua , Xue Wencheng , Liu Xuelin , Qiu Shaofu , Liu Jie 
Published: December 2023

AbstractPathogenic Escherichia coli is of great concern in the clinical setting. But few reports have demonstrated the variation in disease course. We present a severe case of multiple organ dysfunction syndrome caused by E. coli infection. Pathogens isolated from blood and urine samples harboured many virulence factors. Whole‐genome sequencing and conventional analyses showed that the isolates experienced beneficial variations, both genetically and phenotypically, during the disease course. These findings showed that E. coli can cause systemic symptoms and informed us of the importance of assessing the reasons for such variations in pathogens occurring in vivo.
Design and hydraulic performance of bionic leaf vein‐type drip irrigation emitters
Authors: Xu Tianyu , Li Zonglei , Lin Changjiang , Yu Qiuyue 
Published: December 2023

AbstractTo improve the hydraulic performance of leaf vein drip irrigation emitters, a combination of a genetic algorithm and numerical simulation was used to investigate the hydraulic characteristics of the model. The minimal flow index is used as the optimization objective to obtain the best design parameters for the flow channel structure. The results show that the leaf vein drip irrigation emitter has a flow index of 0.53, and the structural loss coefficient of the leaf vein drip irrigation emitter is 64.5–70.9 under 50 kPa working pressure, with a good energy dissipation effect. Among the design variables, the flow index (denoted as x) was influenced in the following order: the width of the unit structure f had the largest impact, followed by the vertical distance from the front baffle c, the inlet width a and the length of the unit structure h. The flow index x exhibited a positive correlation with the inlet width a, the vertical distance from the front baffle c and the length of the unit structure h, while it displayed a negative correlation with the width of the unit structure f. The correlation coefficient between the simulated and measured results was 0.994, with an average error of 2%, and the accuracy of the simulation results was high. Notably, the absence of noticeable low‐velocity vortices at the corners and confluence of the leaf vein flow channel indicated excellent resistance to blockage.
Exploration on load balancing data aggregation algorithm in wireless sensor network based on big data artificial intelligence
Authors: Jiang Huilong 
Published: December 2023

AbstractBased on BD‐AI(Big Data Artificial Intelligence) technology, an efficient LB data collection algorithm was designed and implemented for experimental verification and performance evaluation. The results showed the average load of algorithms A and B tested five times was between 44–48 and 60–64, respectively; the algorithms A and C were tested five times with data transmission speeds between 10–11Mbps and 4–5Mbps, respectively. The LB data aggregation algorithm based on BD‐AI in WSN is more efficient than traditional LB algorithms and traditional data aggregation algorithms. It can effectively help solve problems such as imbalanced data exchange, data redundancy, and energy waste among wireless sensor nodes, thereby improving the data collection efficiency and energy conservation of sensor networks, laying the foundation for implementing application scenarios such as intelligent perception and remote monitoring. The load balancing data aggregation algorithm of wireless sensor networks based on Big data artificial intelligence is faced with some challenges and difficulties. For example, wireless sensor networks usually produce a large amount of data, which needs real‐time aggregation and processing; Nodes in wireless sensor networks typically have limited computing, storage, and communication resources, among other issues.
Dehydrocostus lactone (DHC) promotes osteoblastic differentiation and mineralization through p38/RUNX‐2 signaling
Authors: Wu Shiqiang , Bai Xiaoming , Cai Liquan , Ke Qingfeng , Zhang Xiaolu 
Published: December 2023

AbstractDysregulation of osteoblastic differentiation is an important risk factor of osteoporosis, the therapy of which is challenging. Dehydrocostus lactone (DHC), a sesquiterpene isolated from medicinal plants, has displayed anti‐inflammatory and antitumor properties. In this study, we investigated the effects of DHC on osteoblastic differentiation and mineralization of MC3T3‐E1 cells. Interestingly, we found that DHC increased the expression of marker genes of osteoblastic differentiation, such as alkaline phosphatase (ALP), osteocalcin (OCN), and osteopontin (OPN). Additionally, DHC increased the expressions of collagen type I alpha 1 (Col1a1) and collagen type I alpha 2 (Col1a2). We also demonstrate that DHC increased ALP activity. Importantly, the Alizarin Red S staining assay revealed that DHC enhanced osteoblastic differentiation of MC3T3‐E1 cells. Mechanistically, it is shown that DHC increased the expression of Runx‐2, a central regulator of osteoblastic differentiation. Treatment with DHC also increased the levels of phosphorylated p38, and its blockage using its specific inhibitor SB203580 abolished the effects of DHC on runt‐related transcription factor 2 (Runx‐2) expression and osteoblastic differentiation, suggesting the involvement of p38. Based on these findings, we concluded that DHC might possess a capacity for the treatment of osteoporosis by promoting osteoblastic differentiation.
The platelet storage lesion, what are we working for?
Authors: Liu Cheng , Su Yang , Guo Wanwan , Ma Xiaolong , Qiao Rui 
Published: December 2023

AbstractBackgroundPlatelet concentrate (PC) transfusions are crucial in prevention and treatment of bleeding in infection, surgery, leukemia, and thrombocytopenia patients. Although the technology for platelet preparation and storage has evolved over the decades, there are still challenges in the demand for platelets in blood banks because the platelet shelf life is limited to 5 days due to bacterial contamination and platelet storage lesions (PSLs) at 20–24°C under constant horizontal agitation. In addition, the relations between some adverse effects of platelet transfusions and PSLs have also been considered. Therefore, understanding the mechanisms of PSLs is conducive to obtaining high quality platelets and facilitating safe and effective platelet transfusions.ObjectiveThis review summarizes developments in mechanistic research of PSLs and their relationship with clinical practice, providing insights for future research.MethodsAuthors conducted a search on PubMed and Web of Science using the professional terms “PSL” and “platelet transfusion.” The obtained literature was then roughly categorized based on their research content. Similar studies were grouped into the same sections, and further searches were conducted based on the keywords of each section.ResultsDifferent studies have explored PSLs from various perspectives, including changes in platelet morphology, surface molecules, biological response modifiers (BMRs), metabolism, and proteins and RNA, in an attempt to monitor PSLs and identify intervention targets that could alleviate PSLs. Moreover, novel platelet storage conditions, including platelet additive solutions (PAS) and reconsidered cold storage methods, are explored. There are two approaches to obtaining high‐quality platelets. One approach simulates the in vivo environment to maintain platelet activity, while the other keeps platelets at a low activity level in vitro under low temperatures.ConclusionUnderstanding PSLs helps us identify good intervention targets and assess the therapeutic effects of different PSLs stages for different patients.
Detection of unrecognized myocardial infarction by preprocedural transthoracic echocardiography in patients undergoing elective percutaneous coronary intervention
Authors: Misawa Toru , Hoshino Masahiro , Sugiyama Tomoyo , Kanaji Yoshihisa , Hada Masahiro , Nagamine Tatsuhiro , Ueno Hiroki , Nogami Kai , Sayama Kodai , Matsuda Kazuki , Yonetsu Taishi , Sasano Tetsuo , Kakuta Tsunekazu 
Published: December 2023

AbstractBackgroundPrevious studies showed that unrecognized myocardial infarction (UMI) identified on cardiac magnetic resonance (CMR) was related to worse prognosis. We aimed to investigate the efficacy of preprocedural transthoracic echocardiography (TTE) to detect the presence of UMI in patients undergoing percutaneous coronary intervention (PCI).MethodsA total of 138 patients with chronic coronary syndrome (CCS) and preserved left ventricular ejection fraction (LVEF) without history of myocardial infarction or revascularization were retrospectively studied. UMI was evaluated with pre‐PCI late gadolinium enhancement (LGE)‐CMR. TTE and two‐dimensional speckle‐tracking echocardiography (2D‐STE) were performed before PCI. All patients were divided into two groups according to the presence or absence of UMI, and clinical and echocardiographic findings were compared between these two groups.ResultsUMI was detected in 43 patients (31.2%). Multivariable logistic regression analysis revealed that higher SYNTAX score, the presence of wall motion abnormalities (WMAs) and lower global longitudinal strain (GLS) were independent predictors of the presence of UMI. Furthermore, GLS provided incremental efficacy for the detection of UMI over abnormal Q waves, SYNTAX score and WMAs.ConclusionsPreprocedural TTE in combination with 2D‐STE could help identify patients with UMI regardless of the presence or absence of ECG findings and WMAs.
What does it mean to be “prepared for work”? Perceptions of new engineers
Authors: Deters Jessica R. , Paretti Marie C. , Perry Logan A. , Ott Robin 
Published: December 2023

AbstractBackgroundEngineering education seeks to prepare students for engineering practice, but the concept of preparedness is often ill‐defined. Moreover, findings from studies of different populations or in different contexts vary regarding how well new graduates are prepared. These variations, coupled with the lack of clarity, suggest the need to better understand what it means to be prepared for engineering work.PurposeThis study contributes to research on workplace preparation by exploring how new graduates describe being prepared for engineering work.MethodApplying secondary analysis to data from the multi‐institution Capstone To Work (C2W) project, we used thematic analysis to explore new engineers' descriptions of preparedness. We analyzed written responses to structured questions about the school‐to‐work transition collected weekly during participants' first 12 weeks of work; 105 graduates drawn from four universities provided 956 responses, with a mean of 9 (out of 12 possible) responses per participant.ResultsParticipants' descriptions of preparedness included applying concrete skills, recognizing familiar situations, and having strategies for approaching challenging tasks even when they lacked relevant knowledge or skill.ConclusionOur findings suggest that although many discussions about workplace preparation implicitly focus narrowly on mastery of skills and knowledge, that focus may not fully capture new graduates' experiences, and may limit discussions about the ways in which school can (and cannot) prepare students for work. A more expansive understanding may better support both student learning and workplace onboarding, though more research is needed across stakeholders to establish shared understanding.
An innovative charge‐based extracellular vesicle isolation method for highly efficient extraction of EV‐miRNAs from liquid samples: miRQuick
Authors: Park Junsoo , Bae Minju , Seong Hyeonah , Hong Jin hwa , Kang Su Jin , Park Kyung hwa , Shin Sehyun 
Published: December 2023

AbstractExtracellular vesicle‐derived microRNAs (EV‐miRNAs) are promising biomarkers for early cancer diagnosis. However, existing EV‐miRNA extraction technologies have a complex two‐step process that results in low extraction efficiency and inconsistent results. This study aimed to develop and evaluate a new single‐step extraction method, called miRQuick, for efficient and high‐recovery extraction of EV‐miRNAs from samples. The miRQuick method involves adding positively charged substances to the sample, causing negatively charged EVs to quickly aggregate and precipitate. A membrane lysate is then added to extract only miRNA. The entire process can be completed within an hour using standard laboratory equipment. We validated the miRQuick method using various analytical techniques and compared its performance to other methods for plasma, urine and saliva samples. The miRQuick method demonstrated significantly higher performance than other methods, not only for blood plasma but also for urine and saliva samples. Furthermore, we successfully extracted and detected nine biomarker candidate miRNAs in the plasma of breast cancer patients using miRQuick. Our results demonstrate that miRQuick is a rapid and efficient method for EV‐miRNA extraction with excellent repeatability, making it suitable for various applications including cancer diagnosis.
Transmembrane helix 6 of ABCD4 is indispensable for cobalamin transport
Authors: Imai Momoka , Kawaguchi Kosuke , Morita Masashi , Imanaka Tsuneo , So Takanori 
Published: December 2023

AbstractABCD4, which belongs to the ABC protein subfamily D, plays a role in the transport of cobalamin from lysosomes to the cytosol by cooperating with ATP‐binding and ATP‐hydrolysis. Pathogenic variants in the ABCD4 gene lead to an inherited metabolic disorder characterized by cobalamin deficiency. However, the structural requirements for cobalamin transport in ABCD4 remain unclear. In this study, six proteoliposomes were prepared, each containing a different chimeric ABCD4 protein, wherein each of the six transmembrane (TM) helices was replaced with the corresponding ABCD1. We analyzed the cobalamin transport activities of the ABCD mutants. In the proteoliposome with chimeric ABCD4 replacing TM helix 6, the cobalamin transport activity disappeared without a reduction in ATPase activity, indicating that TM helix 6 contributes to substrate recognition. Furthermore, the substitution of aspartic acid at position 329 or threonine at position 332 in TM helix 6 with the basic amino acid lysine led to a decrease in cobalamin‐transport activity without causing a reduction in ATPase activity. The amino acids in TM helix 6 may be critically involved in substrate recognition; the charged state in the C‐terminal half of TM helix 6 of ABCD4 is responsible for cobalamin transport activity.
Practical identification of cobalt‐based blue pigments detecting the induced photoluminescence by a He‐Ne laser using a Raman spectrometer
Authors: Ruiz‐Moreno Sergio , Soneira MaJosé , Perez‐Pueyo Rosanna 
Published: December 2023

AbstractSince the early 19th century, the pigment historically known as cobalt blue has been one of the most widely used in artistic painting. Its many and excellent properties led to the rapid development of different synthesis processes for the pigments known today under the generic name of cobalt‐based pigments. The differentiation and characterization of these pigments is often difficult, because many of them are made of the same raw materials, mainly cobalt oxides (or salts) and alumina (aluminum oxide), even when Raman spectroscopy is used. In this research, six cobalt‐based trademark pigments and two chemically pure compounds, cobalt aluminate and calcined alumina, have been analyzed using a Raman spectrometer with a red He‐Ne laser (632 nm) as the excitation source. It should be noted that only the Raman band around 517 cm−1 associated with the cobalt aluminate has been detected by the authors in cobalt based pigments with this configuration. In order to obtain additional information, a fundamental aim of this work has been to detect the photoluminescence (PL) emitted by the leftover of calcined alumina (α‐alumina) in these compounds, particularly in the form of a strong doublet located at 1367 and 1396 cm−1. From an experimental point of view, it is remarkable that both Raman and PL information can be acquired within the same spectral range of the spectrometer. Additionally, the relationship between the intensities of the Raman band around 517 cm−1 and those of the doublet can be used as an indicator to estimate the quality of each pigment.