bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacogenetic Variants Can Influence Optical Medication Use
Authors: Alves Diana , Ferreira Filipa , Pereira Cristina , Lopes Altina , Nogueira Célia , Vilarinho Laura 
Published: December 2023

Introduction::
Single Nucleotide Polymorphisms (SNPs) are used as drug susceptibility
biomarkers in metabolic diseases. Alterations in the gene encoding triggers the enzyme flavin
monooxygenase 3 (FMO3), involved in the Sulindac metabolization, which also is responsible
for the inherited metabolic disorder. Trimethylaminuria (TMAu, OMIM: 602079). DPYD
gene variants are associated with the enzyme dihydropyrimidine dehydrogenase deficiency
(DPD; OMIM: 274270). This autosomal recessive metabolic disorder, ultimately leads to the
inability to metabolize fluoropyrimidines, which causes severe toxicity in individuals treated
with these drugs.

Methods::
Variants in genes responsible for the expression of enzymes that encode transporters
or receptors involved in the metabolization pathways of certain drugs may condition the individuals
response to certain drugs, compromising the therapeutic response and clinical prognosis.
Thus the sequencing and identification of variants become relevant, not only gain knowledge on
effects of these variants’ on disease causality but also in terms of its side effects resulting from
the coding enzymes responsible for drug metabolization.

Results::
It was found that patients with the c.472G>A (p.Glu158Lys) and c.923A>G
(p.Glu308Gly) polymorphisms, in homozygosity, in FMO3 gene did not develop polyps, thus
have a protective effect in the treatment of Familial Adenomatous Polyposis (PAF). However,
in the case of the DPYD gene, c.1905+1G>A (IVS14+1G>A), c.1679T>G (p.Ile560Ser),
c.2846A>T (p.Asp949Val) e c.1236G>A/HapB3 variants can be lethal in cancer patients indicated
for fluoropyrimidine-based chemotherapy.

Conclusion::
Knowledge on the drug mechanisms will affect the therapeutic response of patients
treated with a given drug. Thus, pharmacogenetics is an essential tool in personalized medicine,
since molecular studies allows the clinician to predict the probability of efficacy and toxicity of
certain drugs, resulting higher efficiency in individualizing treatment and also improving the
safety of the patient. From a personalized medicine perspective, the study of the characteristics
of the drug and its metabolization site, the genes involved in the encoding of enzymes responsible
for its metabolization will be of great interest.
Increasing Sanfilippo Syndrome Awareness through Children's Literature
and Music
Authors: Marques Raquel , Carlson Rodrigo , Higonnet Guilhain 
Published: December 2023

Abstract:
There is an ongoing effort to increase rare disease awareness amongst healthcare
providers. This front is important and can help to address several challenges faced by rare disease
patients, such as lengthy diagnosis times, difficulty in finding adequate providers of medical
services and experts, and adequate treatment if one exists. On another front, there is the need
for awareness among citizens and their support in the advocacy for public policies towards rare
disease patients and families. Awareness campaigns are prevalent in social networks and fundraising
events. In this poster, we present a complementary approach to engage society and promote
rare disease awareness through children’s literature and music. A Portuguese teenager
wrote a book (‘My Life with my sister’), describing simple and daily moments spent with her
teenage sister affected by Sanfilippo syndrome. A professional illustrator designed and illustrated
the book. The book is bilingual in Portuguese and English. The author, with the assistance of
her music teacher, also composed a song which was recorded with the participation of professional
musicians and made into a video clip telling their story and the books. The book and song
promote the inclusion and love for people affected by rare diseases and their families. To increase
outreach, sister organizations translated the book, adapted the song, and published/
recorded the material in Brazilian Portuguese and French. The proceeds from the sales go towards
the Sanfilippo foundations in their respective countries to fund common research projects.
The material is being advertised on social media, television, interviews, newspapers, podcasts,
libraries, schools, bookshops, book fairs, and others. To date, more than eight hundred
books have been sold to individuals and companies. The interviews and video clips add to more
than twelve hundred views. The target audience is children, parents, teachers but also companies,
and their employees.
Bioleaching Extraction of Valuable Metal From E-Wastes: A Mini
Review
Authors: Jiang Mingjun , He Siyu , Zhang Yongkui 
Published: December 2023

Abstract:
Electrical waste (E-waste) is a significant global issue, with an annual generation
of over 50 million tons, causing detrimental effects on both the environment and human
health. However, E-waste is also known as a secondary valuable metal resource. Although
hydrometallurgy and pyrometallurgy are still the preferred methods for metal recovery
from E-wastes, bioleaching has gained significant attention as a promising alternative
for metal recovery from E-wastes due to its sustainability, environmental friendliness, and
cost efficiency. In this review, different chemical principles of bioleaching were first discussed.
Major bacterial groups that can be applied in bioleaching were then introduced.
The bioleaching procedures and applications have been summarized and analyzed. Finally,
a few perspectives were made on potential future research on bioleaching.
Pengaruh Growth, Cash Ratio, Struktur Kepemilikan Manajerial dan Profitabilitas terhadap Deviden Payout Ratio (DPR) pada Perusahaan Pertambangan yang Terdaftar di Bursa Efek Indonesia (BEI)
Authors: Widiantari Ni Kadek , Wahyuni Made Arie 
Published: December 2023

Abstract
This study was aimed at determining the effect of growth, cash ratio, managerial ownership structure and profitability on the dividend payout ratio in mining companies listed on the Indonesian stock exchange. The type of data which used in this study was quantitative data with secondary data. The data analysis technique used in this study was multiple regression analysis with the Classical Assumption Test, the Coefficient of Determination Test, and the T Test. The population of this study was 49 mining companies listed in Indonesian stock exchange with 13 companies qualified in 5 years, so the sample analised was 65 samples. This study used purposive sampling in determining the sample. The results show that Growth has a significant negative effect on the dividend payout ratio. While cash ratio, managerial ownership structure, profitability have a significant positive effect on the dividend payout ratio in mining companies listed on the Indonesian stock exchange.
Keywords : Deviden Payout Ratio, Growth, Cash Ratio, Managerial Ownership Structure And Profitabilitas.
Pengaruh Whistleblowing System, Kompetensi, Good Corporate Governance, dan Efektivitas Pengendalian Internal terhadap Pencegahan Kecurangan
Authors: Utama Kadek Deni Sandira , Astawa I Gede Putu Banu 
Published: December 2023

Abstract
This study aims to obtain empirical evidence regarding the effect of the whistleblowing system, human resource competence, good corporate governance, and the effectiveness of internal controls on fraud prevention in the management of LPD funds in Buleleng Regency. This research is a quantitative research with 75 respondents. The method of determining the sample using purposive sampling technique. The data used are primary data obtained through a questionnaire and measured using a Likert scale. The data analysis techniques used are Validity Test, Reliability Test, Classic Assumption Test, Multiple Linear Regression Analysis, Coefficient of Determination Test, and t-test with the help of SPSS 26.0 for Windows. The results show that the whistleblowing system, human resource competence, good corporate governance, and the effectiveness of internal control have a positive and significant effect on preventing fraud in the management of LPD funds in Buleleng Regency.

Keywords : fraud prevention, whistleblowing system, human resource competence, good corporate governance, and effectiveness of internal control
Pengaruh Pendapatan Asli Daerah dan Dana Perimbangan Terhadap Alokasi Belanja Modal dengan Budget Ratcheting Sebagai Variabel Moderasi
Authors: Ni Luh Putu Dita Silviani  , I Made Pradana Adiputra  
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pendapatan asli daerah dan dana perimbangan terhadap alokasi belanja modal serta untuk mengetahui pengaruh budget ratcheting dalam memoderasi hubungan masing – masing variabel bebas ke alokasi belanja modal pada pemerintah daerha kabupaten/kota di Provinsi Bali. Jenis data dalam peneilitan ini menggunakan data sekunder berupa laporan keuangan pemda dalam bentuk APBD dan LRA dengan rentang waktu 6 tahun (2016-2021). Penelitian ini menggunakan analisis data berupa regresi linier berjenjang. Hasil penelitian ini menunjukan bahwa pendapatan asli daerah dan dana perimbangan berpengaruh positif signifikan terhadap alokasi belanja modal. Selanjutnya budget ratcheting memiliki sifat moderasi memperkuat pengaruh PAD terhadap alokais belanja modal serta pengaruh dana perimbangan terhadap alokasi belanja modal
Kata Kunci : penganggaran;alokasi belanja modal;pendapatan asli daerah;dana perimbangan;budget ratcheting
HUBUNGAN KECUKUPAN VITAMIN D DENGAN SATURASI OKSIGEN PADA PASIEN COVID-19
Authors: Ghifari Fitra Aslami , Ayusari Amelya Augusthina , Myrtha Risalina , Rahayu Dwi 
Published: December 2023

ABSTRACT
Coronavirus Disease 2019 (COVID-19) infection is a global health problem with rapid transmission and variable prognosis. Oxygen saturation is an indicator for assessing the prognosis of COVID-19 infection. Viral infections are related to the immune system because they are self-limiting diseases. Vitamin D is considered able to improve the immune system through several pathways. There are differences in research results regarding vitamin D and respiratory tract infections. This study aims to determine the relationship between vitamin D adequacy and oxygen saturation in COVID-19 patients at X Surakarta Hospital. This research was an observational analysis with a cross-sectional design on 32 patients who had been treated for COVID-19 at RS X Surakarta. Data on oxygen saturation and vitamin D management were taken from medical records, while food consumption data was completed by filling in a formulary food frequency questionnaire (FFQ). Data analysis used the Chi-Square test (α=0.05). The research results showed that there was no significant relationship (p=0.055) between vitamin D adequacy and oxygen saturation in COVID-19 patients (p>0.05). The conclusion of this study was no relation between vitamin D adequacy and oxygen saturation in COVID-19 patients.

ABSTRAK
Infeksi Coronavirus Disease 2019 (COVID-19) merupakan permasalahan kesehatan global dengan penularan cepat dan prognosis bervariasi. Saturasi oksigen merupakan salah satu indikator untuk menilai prognosis infeksi COVID-19. Infeksi virus berkaitan dengan sistem imun karena bersifat self-limiting disease. Vitamin D dinilai dapat meningkatkan sistem imun melalui beberapa jalur. Terdapat perbedaan hasil penelitian mengenai vitamin D dan infeksi saluran pernapasan. Penelitian ini bertujuan untuk mengetahui hubungan kecukupan vitamin D dengan saturasi oksigen pasien COVID-19 di RS X Surakarta. Penelitian ini bersifat analisis observasional dengan rancangan cross-sectional terhadap 32 pasien yang pernah dirawat COVID-19 di RS X Surakarta. Data saturasi oksigen dan tatalaksana vitamin D diambil dari rekam medis, sedangkan data konsumsi pangan dengan pengisian formular food frequency questionnaire (FFQ). Analisis data menggunakan uji Chi-Square (α=0,05). Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang signifikan (p=0,055) antara kecukupan vitamin D dengan saturasi oksigen pada pasien COVID-19 (p>0,05). Kesimpulan penelitian ini bahwa kecukupan vitamin D tidak berhubungan dengan saturasi oksigen pasien COVID-19.
KORELASI MEAN PLATELET VOLUME TERHADAP DERAJAT KEPARAHAN DAN FREKUENSI KEKAMBUHAN PADA PSORIASIS VULGARIS
Authors: Hashfi Annisa Fildza , Wijayanti Winda , Wijayanti Niluh , Febriani Dina , Mulianto Nurrachmat 
Published: December 2023

ABSTRACT
Psoriasis vulgaris is a chronic systemic inflammatory disease that causes various complications if it is not treated properly. Mean platelet volume (MPV) is a cheap, fast, and efficient marker for predicting the severity and complications of cardiovascular and metabolic syndrome in psoriasis vulgaris patients. The MPV value is also thought has effects on the frequency of recurrence in psoriasis vulgaris patients. The objective of this study was to determine the relationship between MPV and severity using the PASI score and recurrence frequency in psoriasis vulgaris patients. This study used an observational analytic method with a cross sectional. The research respondents were 30 subjects. This study used the Pearson correlation test and the Spearman correlation test. The MPV value had a significant correlation with the disease severity (p= 0,00; r= 0,94) and the recurrence frequency (p= 0,00; r= 0,95) in psoriasis vulgaris patients. We concluded that the increaseased MPV value indicates a higher degree of severity and frequency of recurrence in psoriasis vulgaris patients.

ABSTRAK
Psoriasis vulgaris merupakan penyakit inflamasi kronis sistemik yang menyebabkan berbagai komplikasi apabila tidak mendapatkan terapi yang tepat. Mean platelet volume (MPV) adalah salah satu penanda yang murah, cepat dan efisien untuk memprediksi derajat keparahan dan komplikasi kardiovaskuler serta sindroma metabolik pada pasien psoriasis vulgaris. Nilai MPV juga diduga berpengaruh terhadap derajat keparahan dan frekuensi kekambuhan pada pasien psoriasis vulgaris. Tujuan penelitian ini adalah mengetahui hubungan antara MPV dengan tingkat keparahan dengan menggunakan skor PASI dan frekuensi kekambuhan pada pasien psoriasis vulgaris. Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross sectional. Responden penelitian berjumlah 30 subjek. Penelitian ini menggunakan uji korelasi Pearson dan uji korelasi Spearman. Hasil penelitian menyatakan bahwa nilai MPV memiliki korelasi positif yang signifikan dengan derajat keparahan (p= 0,00; r= 0,94) dan frekuensi kekambuhan (p= 0,00; r= 0,95) pada pasien psoriasis vulgaris. Kesimpulannya bahwa peningkatan nilai MPV menunjukkan derajat keparahan dan frekuensi kekambuhan yang semakin tinggi pada pasien psoriasis vulgaris.
Työntekijöiden toimintakategoriat ”koronakaduilla”
Authors: Virokannas Elina 
Published: December 2023

Tutkimuksessa tarkastellaan kevättalvella 2020 puhjenneen koronapandemian merkityksiä matalan kynnyksen päihdetyölle ja työntekijöiden toimijuudelle Helsingissä. Rajoitusten sulkiessa palveluita useissa organisaatioissa siirryttiin tekemään asiakastyötä kaduille. Tutkimustehtävänä on selvittää, millaisia toimintakategorioita rakentuu työntekijöiden reflektoidessa pandemian alkuvaiheen tapahtumia. Aineistona käytetään kaduille jalkautuneiden työntekijöiden kanssa syksyllä 2021 toteutettuja fokusryhmäkeskusteluita.

Tutkimuksen viitekehyksenä toimii etnometodologiseen tutkimussuuntaukseen nojaava kategoria-analyyttinen tulokulma. Toimintakategorialla viitataan niihin ominaisuuksiin ja piirteisiin, joita keskustelijat liittävät itseensä ja toisiinsa sekä muihin toimijoihin kuvailemiensa tapahtumien eri vaiheissa. Aineistoa on luokiteltu ensin kronologisesti etenevää aineistolähtöistä sisällönanalyysiä hyödyntämällä. Luokittelun pohjalta on muodostettu neljä teemaa: 1) alkuhämmennys ja uusien toimintatapojen luominen, 2) kadulle lähtö ja järjestäytyminen, 3) asiakaskunnan olosuhteet kadulla, 4) henkinen kuormittuneisuus muuttuneissa työskentelyolosuhteissa. Tämän jälkeen teemoja on tarkasteltu kategoria-analyyttisellä otteella.

Tuloksena esiteltävät työntekijöille rakentuvat toimintakategoriat olivat vastuuntuntoinen ammattilaisuus, eettismoraalinen yhteistoimijuus, hätään reagoiva rajallinen toimijuus ja väsynyt toimijuus. Aineistossa korostui luovaa ammattilaisuutta ja vastuuntuntoisuutta ilmentäviin toimintakategorioihin identifioituminen, mutta samanaikaisesti toimintamahdollisuuksien rajallisuus, arvostuksen puute ja voimien ehtyminen tulivat esiin.

Työntekijöiden henkisen kuormituksen tilaa tulisi tarkastella pidemmällä aikavälillä sekä pohtia keinoja matalan kynnyksen työn asianmukaiseen resurssointiin ja arvostuksen lisäämiseen. Yhteiskunnan valmiuksia kohdata kriisitilanteita tulisi jatkossa tarkastella monipuolisesti ja laatia toimintasuunnitelmat, jotka turvaisivat haavoittuvissa elämäntilanteissa olevien ihmisarvoisen elämän.
Kuntien kokonaisulkoistusten kustannusvaikutukset: rekisteriaineistoon perustuva analyysi
Authors: Jokimies Lotta , Rantsi Mervi , Linna Miika 
Published: December 2023

Terveyspalvelujen ulkoistaminen on lisääntynyt viime vuosina, mutta ulkoistamisen kustannusvaikutuksista on vähän tutkimustietoa. Tämän tutkimuksen tavoitteena oli selvittää eroavatko kokonaisulkoistaneiden kuntien terveyspalvelujen standardi- tai nettokäyttökustannukset palvelut omana tuotantona tuottavien kuntien kustannuksista.

Tutkimus perustuu Suomen akatemian STN IMPRO-tutkimusprojektin rekisteriaineistoon, joka sisältää tiedot kuntien terveyspalvelujen käytöstä, sekä Terveyden ja hyvinvoinnin laitoksen Sotkanet-tietokannan tietoihin kuntien nettokäyttökustannuksista. Tutkimuksessa verrattiin useiden aikajaksojen difference-in-differences -menetelmän avulla kokonaisulkoistuksen vuosina 2016–2018 tehneiden kuntien (n=14) terveyspalvelujen standardi- ja nettokäyttökustannuksia verrokkikuntien (n=218) vastaaviin kustannuksiin. Valitun menetelmän avulla voitiin arvioida ulkoistuksen vaikutuksia kunnissa, joissa ulkoistaminen on alkanut eri vuosina.

Kokonaisulkoistuksella ei ollut vaikutusta perusterveydenhuollon standardikustannuksiin (59,0 €/asukas, p=0,296), mutta perusterveydenhuollon nettokäyttökustannukset laskivat (-154,9 €/asukas, p=0,001) verrattuna oman tuotannon kuntiin. Erikoissairaanhoidon standardikustannukset laskivat (-96,4 €/asukas, p=0,027), mutta nettokäyttökustannukset eivät muuttuneet (38,7 €/asukas, p=0,373). Terveystoimen standardikustannuksissa (37,4 €/asukas, p= 0,621) tai nettokäyttökustannuksissa (-116,1 €/asukas, p=0,108) ei havaittu tilastollisesti merkitsevää vaikutusta.

Kokonaisulkoistuksen tehneiden kuntien erikoissairaanhoidon käytön kokonaismäärä standardikustannuksina mitattuna laski, mutta tämä ei näkynyt nettokäyttökustannuksissa. Kokonaisulkoistuksen tehneiden kuntien perusterveydenhuollon nettokäyttökustannukset asukasta kohden puolestaan laskivat vaikka käytön määrä ei muuttunut. Tutkimuksessa havaittujen palvelujen käytön määrän ja niitä vastaavien nettokustannusten poikkeamien taustalla olevien tekijöiden selvittäminen edellyttää jatkotutkimuksia.
Michael Scot and the Music of the Spheres
Authors: Scott Tony , Harper David 
Published: December 2023

Herein, it is shown that Kepler’s contribution involving the “Music of the Spheres” can be traced back to Pythagoras and Ibn Arabī through Michael Scot. We ﬁnd threads linking this body of work associating music with astronomy leading to the modern and extensive astronomical subject of orbital resonances. In particular, we ﬁnd that Fibonacci numbers play a signiﬁcant role in this context.
trajetória de um Programa de Pós-Graduação da Área de PLURD em uma universidade privada no Nordeste do Brasil
Authors: Souza Laumar Neves de , Spinola Noelio Dantasle , Spinola Carolina de Andrade 
Published: December 2023

O objetivo deste artigo é historiar os acontecimentos que marcaram e definiram a trajetória do Programa de Pós-Graduação em Desenvolvimento Regional e Urbano (PPDRU) da Universidade Salvador (UNIFACS). Para levar esse propósito adiante, recorreu-se às informações disponibilizadas pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), assim como aos documentos internos do Programa que dão conta, entre outras coisas, dos objetivos que, desde o seu início, ele pretendia alcançar na formação de egressos e na sua contribuição acadêmica para os planos estadual e regional. Entre os achados a que se chegou nesse empreendimento investigativo, tornou-se evidente que o PPDRU se constitui em um Programa de Pós-Graduação (PPG) que, através de sua estruturação curricular, de seus grupos de pesquisa e esforços de inserção social, concentra seus esforços na formação de agentes públicos e privados promotores do desenvolvimento, mobilizando a ciência em apoio concreto e direto à sociedade.
Palavras-chave: Educação. Desenvolvimento. Pós-Graduação. Stricto Sensu. Nordeste.
área de Planejamento Urbano e Regional e Demografia no contexto da pós-graduação brasileira
Authors: Silva Christian Luiz da , Shimoda Eduardo , Batista Fábio Barbosa , Carmo Roberto Luiz do , Rocha Junior Weimar Freire da 
Published: December 2023

O Sistema Nacional de Pós-graduação (SNPG) cresceu significativamente desde o final da década de 1990. Dentre as diversas áreas que compõe SNPG, uma das que mais se expandiu foi a de Planejamento Urbano e Regional e Demografia (PLURD). O objetivo desse artigo é analisar essa expansão, considerando a expansão do número de programas de pós-graduação, características do corpo docente e dos egressos, dentro do contexto geral da evolução do orçamento da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os dados utilizados são públicos, oriundo da própria Capes, referentes a avaliações anteriores, contendo planilhas com indicadores médios das áreas de avaliação da CAPES. Para dar conta dessa tarefa foi empregado o método descritivo, com a utilização de dados quantitativos do processo de avaliação dos programas de pós-graduação realizado pela CAPES. Aborda-se com detalhamento o quadriênio 2013-2016. As principais conclusões apontam para o dilema enfrentado pelo SNPG, em termos da continuidade da expansão e da disparidade regional na localização dos programas. O contexto torna-se ainda mais desafiador por conta da queda brusca do orçamento da CAPES especialmente a partir de 2015, que dificulta a consolidação de muitos programas que ainda necessitam de recursos significativos para se estruturarem.
Palavras-chave: Sistema Nacional de Pós-Graduação. CAPES. Planejamento Urbano e Regional e Demografia. Brasil. Desigualdades Regionais.
programa de Pós-Graduação em Desenvolvimento Regional da Universidade do Contestado (PPGDR/UNC)
Authors: Tomporoski Alexandre Assis , Bazzanella Sandro Luiz , Gumbowsky Argos , Marchesan Jairo 
Published: December 2023

O presente artigo tem por objetivo apresentar, num primeiro momento, o Programa de Pós-Graduação em Desenvolvimento Regional da Universidade do Contestado (PPGDR/UNC). O mesmo foi criado no ano de 2006, no município de Canoinhas, região do Planalto Norte de Santa Catarina. Após uma década de atuação e a ascensão à nota 4 (quatro) no ciclo avaliativo da CAPES, o Programa obteve a aprovação de seu curso de Doutorado no ano de 2019. Ao longo de sua trajetória até a atualidade o Programa contribui cientificamente por meio das pesquisas realizadas pelos seus docentes e discentes com diagnósticos em torno das potencialidades e limites do desenvolvimento regional. No âmbito da ação, ou da prática, formou mestres e está formando doutores qualificados para desempenho profissional em âmbito público e privado. Ressalte-se ainda o amplo debate realizado com a administração pública e privada em torno de iniciativas de desenvolvimento. Num segundo momento, o artigo aborda aspectos constitutivos da subárea do desenvolvimento regional no âmbito da área do Planejamento Urbano Regional e Demografia (PLURD). O artigo conclui posicionando desafios ao PPGDR/UNC, bem como a subárea do desenvolvimento regional como forma de intensificar o debate com a comunidade acadêmica.
Palavras-chaves: PPGDR/UNC. Área PLURD. Desenvolvimento regional.