bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Roles and Contribution of Spiritual Care Practitioners in Mental Health: An Australian Study
Authors: Malviya Shikha , Greenham Jenny 
Published: January 2025

Abstract
Mental health is inherently multidimensional, requiring a holistic approach to intervention that integrates various aspects of an individual’s well-being. Spirituality, a vital component of mental health, remains under addressed in Australian mental healthcare. Spiritual care practitioners may play a key role in addressing spiritual needs in mental healthcare; however, their roles and contributions in this context remain unexplored in the extant literature. Bridging this gap, this study explores the potential role of spiritual care practitioners within mental health context. Using a qualitative research approach, this study engaged eight experienced spiritual care practitioners working in various mental health settings across Australia (n = 8). Through reflexive thematic analysis, the study identified and examined the practitioners’ perspectives on their roles and contributions. The findings were summarised in three overarching themes: (1) Core values; (2) Unique contributions in mental health; and (3) Spiritual care practitioners in the mental health system. The study’s findings suggest that by employing a person-centred approach, spiritual care practitioners can play a crucial role in mental health assessments and interventions. Their contributions include providing insights rooted in clients’ unique spiritual beliefs, aiding in the discernment between spiritual experiences and psychopathological symptoms, advocating for clients’ spiritual needs, and supporting the education of mental health professionals. The study also highlights the need for professional recognition of spiritual care practitioners and their greater integration within the mental health system.
A Randomized Controlled Trial Assessing the Psychological Benefits of a Daily Examen-Based Practice
Authors: Plante Thomas G. , Feldman David B. , Ge Jacqueline , Cortese Anthony 
Published: January 2025

Abstract
This is a randomized controlled trial of an Examen-based practice, an intervention reflecting a five-step daily reflection and prayer practice developed by St. Ignatius of Loyola, founder of the Catholic Jesuit order. Like other practices (e.g., mindfulness, yoga), this practice can be used as a spiritual or secular intervention to help people with a variety of challenges and stressors. In this exploratory study, 57 university students were randomly assigned to a two-week daily Examen-based condition, while 58 students were assigned to a wait-list control condition. Questionnaires measuring hope, life meaning, satisfaction with life, mindfulness, compassion, stress, anxiety, and depression were administered pre- and post-intervention and subsequently at two-week follow-up. Significant differences were found for conditions on the measures of life meaning, satisfaction with life, and hope, suggesting that the Examen-based practice produces improvements in individuals’ global evaluations of their lives as well as their perceptions of the future. Suggestions for further research are offered.
Synthesize and characterization of a novel sol–gel-driven Bi2O3 semiconductor: complete degradation and fast photocatalytic activity for paracetamol
Authors: Akşit Derman , Sayil Cigdem , Soylu Gülin Selda Pozan 
Published: January 2025

Abstract
The pollutants are getting released fluently as a waste from the pharmaceutical pollutants leading to the decrease in quality of water. The widespread occurrence of pharmaceutical pollutants poses a serious threat to the environment and human health. Besides, today carbon dioxide emissions and other forms of pollution appear to be a critical global issue. In this study, Bi2O3 catalyst has been prepared via co-precipitation (CP) and a facile sol–gel (SG) methods used as photocatalyst for the degradation of paracetamol (PAR) under different light sources. The preparation method has significant effect on the optical and structural properties of the catalysts. The tetragonal phase of Bi2O3, the presence of more surface OH groups and lower band gap energy remarkably improved the sun-light-driven photoactivity of PAR. The photocatalysts have been characterized by some structural and morphological analysis techniques and optical analysis techniques. In addition, zeta potential (ZP) measurements were performed to explain the impact of the initial pH of solution on photocatalytic degradation. Identification of PAR and the reaction intermediates was determined using Liquid Chromatography-Mass/Mass Spectrometry (LC-MS/MS) technique. Higher photocatalytic activity was obtained with the Bi2O3-SG (1:2) catalyst at pH 5 compared to the activity of Bi2O3-CP. Moreover, Bi2O3-SG (1:2) achieved the highest photocatalytic activity at pH 3. The photocatalytic activity was enhanced, and the time required for 100% degradation of PAR was reduced from 60 min to 30 min and 15 min under UVB irradiation and directly sun light irradiation, respectively. The highest reaction rate (0.086 (min−1)) were obtained in 15 min with the Bi2O3-SG (1:2) catalyst. The results showed TOC removal could be achieved in 60 min 99.19 and 88.97% for Bi2O3-SG and Bi2O3-CP, respectively. In general, sol–gel-driven Bi2O3 as a flower and needle-like morphology, can reveal excellent opportunities in the photocatalytic technology.

Graphical Abstract
Dual-roles and beyond: values, ethics, and practices in forensic mental health decision-making
Authors: Pedersen Sven H. , Radovic Susanna , Nilsson Thomas , Eriksson Lena 
Published: January 2025

Abstract
Forensic mental health services (FMHS) involve restricting certain individual rights to uphold or promote other ethical values – the restriction of liberty in various forms is justified with reference to health and safety of the individual and the community. The tension that arises from this has been construed as a hallmark of the practice and an ever-present quandary for practitioners. Stating this ethical dilemma upfront is a common point of departure for many texts discussing FMHS. But do we run the risk of missing something important if setting the ethical scene rather than exploring it? This paper draws on interviews with three types of interested parties in mental health law proceedings – patients, psychiatrists and public defenders, and seeks to tease out what values are enacted when they describe and discuss experiences of FMHS and court proceedings. In doing so, we find emphasized values such as acceptance, telling it like it is, atonement, normality, and ensuring the future. We find that well-delineated and separate values are not necessarily the basis for decisions. We also find potential for explanation and guidance in bringing ethical discourse closer to everyday practice.
Healthcare exceptionalism: should healthcare be treated differently when it comes to reducing greenhouse gas emissions?
Authors: Parker Joshua 
Published: January 2025

Abstract
Healthcare systems produce significant greenhouse gas emissions, raising an important question: should healthcare be treated like any other polluter when it comes to reducing its emissions, or is healthcare special because of its essential societal role? On one hand, reducing emissions is critical to combat climate change. On the other, healthcare depends on emissions to deliver vital services. The resulting tension surrounds an idea of healthcare exceptionalism and leads to the question I consider in this paper: to what extent (if any) should the valuable goals of healthcare form an exception to the burdens of reducing greenhouse gas emissions? The goals of this paper are twofold. One is to think about how to address the issue of healthcare exceptionalism. Second is to discuss the extent of healthcare’s climatic responsibilities. I examine two perspectives on healthcare exceptionalism. The first treats a responsibility to reduce emissions and the delivery of healthcare as separate issues, each governed by its own principle. I reject this view, proposing instead that we consider healthcare’s environmental responsibilities in conjunction with its essential functions. I defend an “inability to pay” principle, suggesting that while healthcare should indeed contribute to mitigating climate change, its obligations should be constrained by the necessity of maintaining its core goals like protecting health and preventing disease. Healthcare should be treated differently from other sectors, but not to the extent that it is entirely exempt from efforts to reduce emissions.
Mining population opinion about local police
Authors: Matos Kenny , Ribeiro Ricardo , Ferreira João C. 
Published: January 2025

Abstract
Sentiment analysis, or opinion mining, is an important task of natural language processing (NLP) that extracts opinions, attitudes, and emotions from text. With the growth of digital platforms like blogs and social networks, opinion mining has become a key tool for organizations to understand public sentiment. In recent research, machine learning and lexicon-based approaches have been applied to analyze sentiments. Our work specifically focuses on national security, where sentiment analysis offers crucial insights into local opinions, helping authorities gauge public mood. As part of our research, we developed the Public Sensing about Police Platform, a prototype system designed to analyze emotions from social networks. This system generates dashboards for law enforcement and security agencies, providing actionable intelligence for public safety. Our findings show that “Hate” was the most common emotion expressed in relation to police interventions, indicating widespread unpopularity of these actions and a resulting sense of insecurity among the public.
Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies
Authors: Fleseriu Maria , Pivonello Rosario , Newell-Price John , Gadelha Mônica R. , Biller Beverly M. K. , Auchus Richard J. , Feelders Richard A. , Shimatsu Akira , Witek Przemysław , Bex Marie , Piacentini Andrea , Pedroncelli Alberto M. , Lacroix André 
Published: January 2025

Abstract

Purpose
To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing’s disease.

Methods
Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.

Results
Of 210 patients, 82.9% met criteria for hypertension and 40.0% for diabetes at baseline. In patients with hypertension, reductions in mean SBP/DBP were observed from week (W)12 to W72, and 49.1%/58.5% of patients with high SBP/DBP (> 130/>90 mmHg) at baseline had normotensive levels at W72. Antihypertensive medication dose was reduced/stopped in 26.8% of patients, and the proportion taking antihypertensive medication decreased from 54.3% at baseline to 47.3% at W72. In patients with diabetes, mean FPG and HbA1c decreased from W12 to W72, and 33.3%/61.5% with high FPG/HbA1c (≥ 100 mg/dL/≥6.5%) at baseline had normal levels at W72. Antihyperglycemic medication dose was reduced/stopped in 35.7% of patients, and the proportion taking antihyperglycemic medication decreased from 21.9% at baseline to 17.1% at W72; improvements in SBP/DBP and FPG/HbA1c were correlated with improvement in mean urinary free cortisol but not weight change. BP/glycemic parameters generally remained normal in patients without hypertension/diabetes at baseline.

Conclusions
Patients with Cushing’s disease and comorbid hypertension/diabetes receiving osilodrostat had rapid and sustained improvements in SBP/DBP and glycemic control, respectively.
Correlates of prolonged length of stay after endoscopic transsphenoidal surgery for pituitary adenomas: varying definitions and non-clinical factors
Authors: Shah Khushi H. , Susic Nikola , DiStefano Nicholas V. , Knott Maxon V. , Khalafallah Adham M. , Lu Victor M. , Benjamin Carolina G. , Shah Ashish H. , Sargi Zoukaa B. , Komotar Ricardo J. , Ivan Michael E. 
Published: January 2025

Abstract

Purpose
Prolonged length of stay (PLOS) can lead to resource misallocation and higher complication risks. However, there is no consensus on defining PLOS for endoscopic transsphenoidal pituitary surgery (ETPS). Therefore, we investigated the impact of varying PLOS definitions on factors associated with PLOS in patients undergoing ETPS.

Methods
We conducted a retrospective review of patients with pituitary adenomas who underwent ETPS at our institution from 2012 to 2023. Patients were divided into non-PLOS and PLOS groups based on varying definitions of PLOS: > median, > 4 days, > 75th percentile, and > 90th percentile. Bivariate statistical analyses were conducted using Fisher’s exact test, chi-square test, and t-tests. Univariate and multivariate logistic regression identified significant predictors for each PLOS definition.

Results
Our cohort (n = 808) had a mean age of 54.37 ± 16.06 years, 50.43% male, and a median LOS of 3 days. The 75th and 90th percentiles of LOS were 4 and 6 days, respectively. The way PLOS was defined influenced associated factors identified. Preoperative KPS score, non-private insurance, and non-home discharge disposition were associated with PLOS across all definitions used (p < 0.05). Increased preoperative tumor volumes and postoperative hyponatremia were associated with PLOS only when defined by the 75th and 90th percentiles (p < 0.05). Non-White race and low income were significantly associated with PLOS > median while intraoperative CSF leak was a significant predictor for PLOS > 90th percentile (p < 0.05).

Conclusion
Our study highlights the variability in predictors of PLOS based on its definition and emphasizes the role of non-clinical factors on LOS.
Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia
Authors: Atila Cihan , Lustenberger Sven , Chifu Irina , Ferrante Emanuele , Erlic Zoran , Drummond Juliana B. , Indirli Rita , Drexhage Roosmarijn , Powlson Andrew S. , Gurnell Mark , Santana Soares Beatriz , Hofland Johannes , Beuschlein Felix , Fassnacht Martin , Winzeler Bettina , Refardt Julie , Christ-Crain Mirjam 
Published: January 2025

Abstract

Background
Arginine infusion stimulates copeptin secretion, a surrogate marker of arginine vasopressin (AVP), thereby serving as a diagnostic test in the differential diagnosis of suspected AVP deficiency (AVP-D). Yet, the precise mechanism underlying the stimulatory effect of arginine on the vasopressinergic system remains elusive. Arginine plays a significant role in the urea cycle and increases the production of urea. An increase in plasma urea concentration raises blood osmolality, thereby possibly stimulating AVP release. We therefore hypothesized that the stimulatory effect of arginine on AVP may involve an increase in plasma urea levels.

Methods
This analysis combined data from two prospective diagnostic studies. In total, 30 healthy adults (HA), 69 patients with AVP-D, and 89 patients with primary polydipsia (PP) underwent the arginine stimulation test. Infusion of arginine (L-­arginine­-hydrochloride 21%) at a dose of 0.5 g/kg body weight diluted in 500 mL of 0.9% normal saline was administered over 30 min. Blood was collected at baseline and 60, 90, and 120 min to analyze plasma copeptin and urea. The main objective was to investigate urea dynamics in response to arginine administration and its effect on copeptin release.

Results
Plasma urea levels at baseline were comparable and increased 60 min after arginine infusion with a median (IQR) change of + 1.1 mmol/L (+ 0.8, + 1.5) in HA, + 1.4 mmol/L (+ 1.1, + 1.7) in patients with AVP-D and + 1.3 mmol/L (+ 0.9, + 1.5) in patients with PP. Concurrently, plasma copeptin levels substantially increased 60 min from baseline in HA (median change + 5.3 pmol/L (+ 3.2, + 8.8)) and in patients with PP (median change + 2.4 pmol/L (+ 1.2, + 3.8)), but remained stable in patients with AVP-D (median change + 0.3 pmol/L (+ 0.1, + 0.6)). Plasma urea and copeptin levels correlated the most in HA, with a Spearman’s rho of 0.41 at baseline. Patients with AVP-D and PP showed only weak correlations of plasma urea and copeptin, with a correlation coefficient between 0.01 and 0.28.

Conclusion
We demonstrate a slight increase in plasma urea levels in response to arginine, but plasma urea and copeptin levels were weakly correlated. Based on these findings, the stimulatory effect of arginine on AVP cannot be explained primarily by increasing urea levels.
Biofortification of Acacia and Polyflower Honey with Pine sylvestris L. Bud Extracts: Exploring Antioxidant Variation Across Developmental Stages for Enhanced Nutritional Value
Authors: Szanto Lidia Gizella , Marc Romina Alina , Mureşan Andruța Elena , Mureșan Crina Carmen , Puşacş Andreea , Ranga Floricuța , Fetea Florinela , Moraru Paula Ioana , Filip Miuța , Muste Sevastița 
Published: January 2025

Abstract
Honey is a valuable natural product with antioxidant properties, and its quality is influenced by various factors, including botanical origin and biofortification. Pine bud extracts, known for their antioxidant capacity, were explored to enhance the properties of acacia and polyflower honey. This study aimed to investigate the effect of pine bud extracts at different maturation stages on the moisture content, dry matter, antioxidant activity, and total phenolic content (TPC) of acacia and polyflower honey. Acacia and polyflower honey were biofortified with pine bud extracts at three maturation stages (Stage I, Stage II, and Stage III). Various analyses were performed, including moisture and dry matter content determination, total phenolic content measurement using the Folin-Ciocalteu method, and antioxidant activity assessment through DPPH radical scavenging. FTIR analysis was used to study the chemical composition of the biofortified honeys. Results showed that Acacia and polyflower honey maintained moisture content below 20%, with biofortification significantly enhancing their antioxidant profiles. The highest total phenolic content (247 ± 0.04 mg GAE/100 g) and DPPH scavenging activity (55 ± 0.05%) were observed in Acacia honey biofortified at maturation stage II. Polyflower honey exhibited increased phenolic content (232.9 ± 0.9 mg GAE/100 g) and antioxidant activity (52.45%) when biofortified at maturation stage II. Significant color changes were observed in polyflower honey, with a* and b* values increasing, indicating darker coloration. The biofortification of honey with pine bud extracts enhances its antioxidant and nutritional profile. This approach holds potential for the production of functional foods with improved health benefits. Further studies should explore its commercial feasibility and other potential bioactive compounds.
Validation of the FROM-16 in family members of patients receiving advanced therapy medicinal product (ATMP)
Authors: Brilliant Charles D. , Finlay Andrew Y. , Salek Sam M. , Shah Rubina , Bacon Emily , Laing Hamish 
Published: January 2025

Abstract

Purpose
Outcome-based pricing models which consider domains of value not previously considered in healthcare, such as societal outcomes, are of increasing interest for healthcare systems. Societal outcomes can include family-reported outcome measures (FROMs), which measure the impact of disease upon the patient’s family members. The FROM-16 is a generic and easy-to-use family quality of life tool, but it has never been used in the context of patients undergoing advanced therapy medicinal product (ATMP) treatment. The use of potentially curative ATMPs is limited due their high cost and the low number of eligible patients. Using the FROM-16 to collect the impact on family of disease and treatment in ATMP patients may demonstrate additional value created by an ATMP intervention and strengthen the case for its use.

Methods
This feasibility study aimed to test the validity of the FROM-16 in family members of ATMP patients as a prelude for its use in ATMP value estimation. Patients and family members (n = 24) were recruited from ATMP treatment centres in England and Wales. Family members completed the FROM-16 and were invited to a short debriefing interview.

Results
The FROM-16 showed high validity demonstrated by strong internal consistency (Cronbach’s alpha = 0.917) and intraclass correlation (0.803, 95%). Interviews identified that whilst the FROM-16 covered most areas of quality-of-life impact experienced by the participants, some explained that they also experienced other impacts upon their personal health and future outlook.

Conclusion
This feasibility study provides evidence that the FROM-16 could be used as part of a structured systematic approach to measure family quality of life impact in ATMP patients.
Standardized Testing for Diverse Talent Identification: A Framework to Address Geographical Bias in Standardized Testing and Increase Diversity in College Admissions in the Post-Affirmative Action/Race-Neutral Admissions Era
Authors: Canché Manuel S. González , Zheng Kaiwen , Song Yantao , Liang Yunhao 
Published: January 2025

Abstract
Despite the emergence of test-optional policies, standardized admission tests continue shaping the college composition and financial aid prospects of hundreds of thousands of students. This is concerning for the following reasons: (a) standardized test results have historically favored test-takers from wealthier and majority backgrounds, (b) test optional policies have prominently not translated into more diverse student bodies, and (c) on June 29, 2023, the Supreme Court ruled unconstitutional to consider race and ethnicity in college admission decisions. All of which threatens student body diversity in the United States. With this context in mind, this study contributes to this literature in three ways. Methodologically, based on spatial econometrics, neighborhood effects, and concentrated advantage/disadvantage literatures, and employing two different analytic samples, one at the state level and one national in scope, the study demonstrates that variations in test performance are explained by test-takers' spatially contextualized circumstances beyond their individual-level characteristics. Substantively, the study identifies relevant place-based, geographical predictors of performance on standardized tests. Pragmatically, our study offers researchers and admission officers with a tool that enables the easy identification of outstanding, qualified test-takers whom, despite experiencing life in places with high levels of socioeconomic hardship, mastered these tests, statistically outperforming in doing so their peers who grew up in the same neighborhoods. From this perspective, our proposed framework offers a feasible solution to the challenge of locating what Hoxby and Avery referred to as the hidden supply of high-achieving, low-income students. Accordingly, the overarching goal of this study aligns with the notion of talent maximization/human capitalization by providing a reproducible tool (replication code access: https://cutt.ly/3wvv2kgr) to identify high achieving students located in at risk areas. Since the identification framework of outstanding test-takers discussed in this study does not consider race or ethnicity, it does not violate the Supreme Court’s ruling that prevents using race and ethnicity for admission decisions. Remarkably, our proposed high-achieving, low-income students detection framework does identify standardized test-takers living in highly socioeconomic and ethnic diverse neighborhoods (see https://cutt.ly/hwvraSQD), which if recruited by admission officers and offered financial aid, may contribute to making the selection process more equitable, fairer, and may ultimately translate into more diverse student bodies.