bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of lower extremity infections: predisposing conditions, atypical infections, mimics, and differentiating features
Authors: Matcuk George R. , Katal Sanaz , Gholamrezanezhad Ali , Spinnato Paolo , Waldman Leah E. , Fields Brandon K. K. , Patel Dakshesh B. , Skalski Matthew R. 
Published: January 2024

AbstractImaging evaluation for lower extremity infections can be complicated, especially in the setting of underlying conditions and with atypical infections. Predisposing conditions are discussed, including diabetes mellitus, peripheral arterial disease, neuropathic arthropathy, and intravenous drug abuse, as well as differentiating features of infectious versus non-infectious disease. Atypical infections such as viral, mycobacterial, fungal, and parasitic infections and their imaging features are also reviewed. Potential mimics of lower extremity infection including chronic nonbacterial osteomyelitis, foreign body granuloma, gout, inflammatory arthropathies, lymphedema, and Morel-Lavallée lesions, and their differentiating features are also explored.
Diagnostic performance of 3D automated breast ultrasound (3D-ABUS) in a clinical screening setting—a retrospective study
Authors: Klein Wolterink Femke , Ab Mumin Nazimah , Appelman Linda , Derks-Rekers Monique , Imhof-Tas Mechli , Lardenoije Susanne , van der Leest Marloes , Mann Ritse M. 
Published: January 2024

Abstract
Objectives
To assess the diagnostic performance of 3D automated breast ultrasound (3D-ABUS) in breast cancer screening in a clinical setting.

Materials and methods
All patients who had 3D-ABUS between January 2014 and January 2022 for screening were included in this retrospective study. The images were reported by 1 of 6 breast radiologists based on the Breast Imaging Reporting and Data Systems (BI-RADS). The 3D-ABUS was reviewed together with the digital breast tomosynthesis (DBT). Recall rate, biopsy rate, positive predictive value (PPV) and cancer detection yield were calculated.

Results
In total, 3616 studies were performed in 1555 women (breast density C/D 95.5% (n = 3455/3616), breast density A/B 4.0% (n = 144/3616), density unknown (0.5% (n = 17/3616)). A total of 259 lesions were detected on 3D-ABUS (87.6% (n = 227/259) masses and 12.4% (n = 32/259) architectural distortions). The recall rate was 5.2% (n = 188/3616) (CI 4.5–6.0%) with only 36.7% (n = 69/188) cases recalled to another date. Moreover, recall declined over time. There were 3.4% (n = 123/3616) biopsies performed, with 52.8% (n = 65/123) biopsies due to an abnormality detected in 3D-ABUS alone. Ten of 65 lesions were malignant, resulting in a positive predictive value (PPV) of 15.4% (n = 10/65) (CI 7.6–26.5%)). The cancer detection yield of 3D-ABUS is 2.77 per 1000 screening tests (CI 1.30–5.1).

Conclusion
The cancer detection yield of 3D-ABUS in a real clinical screening setting is comparable to the results reported in previous prospective studies, with lower recall and biopsy rates. 3D-ABUS also may be an alternative for screening when mammography is not possible or declined.

Clinical relevance statement
3D automated breast ultrasound screening performance in a clinical setting is comparable to previous prospective studies, with better recall and biopsy rates.

Key Points
• 3D automated breast ultrasound is a reliable and reproducible tool that provides a three-dimensional representation of the breast and allows image visualisation in axial, coronal and sagittal.
• The diagnostic performance of 3D automated breast ultrasound in a real clinical setting is comparable to its performance in previously published prospective studies, with improved recall and biopsy rates.
• 3D automated breast ultrasound is a useful adjunct to mammography in dense breasts and may be an alternative for screening when mammography is not possible or declined.
Intramedullary spinal capillary hemangioma with secondary neurulation defect in children
Authors: Lee Jong Seok , Lee Ji Yeoun , Park Sung-Hye , Wang Kyu-Chang , Kim Kyung Hyun 
Published: January 2024

AbstractIntramedullary spinal capillary hemangioma is a rare occurrence in pediatric patients, and only limited cases have been reported. This study presents the first two cases of spinal capillary hemangioma co-present with retained medullary cord and one case of spinal capillary hemangioma with lumbosacral lipomatous malformation. Previous literature on ten patients with this pathology was reviewed. We speculated pathogenesis, imaging features, and histopathologic findings of the disease.
Soluble terminal complement complex blood levels are elevated in schizophrenia
Authors: Savukoski Susa , Mannes Marco , Wohlgemuth Lisa , Schultze Anke , Guest Paul C. , Meyer-Lotz Gabriela , Dobrowolny Henrik , Relja Borna , Huber-Lang Markus , Steiner Johann 
Published: January 2024

AbstractThe role of the complement system in schizophrenia (Sz) is inconclusive due to heterogeneity of the disease and study designs. Here, we assessed the levels of complement activation products and functionality of the classical pathway in acutely ill unmedicated Sz patients at baseline and after 6 weeks of treatment versus matched controls. The study included analyses of the terminal complement complex (sTCC) and C5a in plasma from 96 patients and 96 controls by enzyme-linked immunosorbent assay. Sub-group analysis of serum was conducted for measurement of C4 component and activity of the classical pathway (28 and 24 cases per cohort, respectively). We found no differences in levels of C5a, C4 and classical pathway function in patients versus controls. Plasma sTCC was significantly higher in patients [486 (392–659) ng/mL, n = 96] compared to controls [389 (304–612) ng/mL, n = 96] (p = 0.027, δ = 0.185), but not associated with clinical symptom ratings or treatment. The differences in sTCC between Sz and controls were confirmed using an Aligned Rank Transformation model considering the covariates age and sex (p = 0.040). Additional analysis showed that sTCC was significantly associated with C-reactive protein (CRP; p = 0.006). These findings suggest that sTCC plays a role in Sz as a trait marker of non-specific chronic immune activation, as previously described for CRP. Future longitudinal analyses with more sampling time points from early recognition centres for psychoses may be helpful to better understand the temporal dynamics of innate immune system changes during psychosis development.
Relation between task-related activity modulation and cortical inhibitory function in schizophrenia and healthy controls: a TMS–EEG study
Authors: Fernández-Linsenbarth Inés , Mijancos-Martínez Gema , Bachiller Alejandro , Núñez Pablo , Rodríguez-González Víctor , Beño-Ruiz-de-la-Sierra Rosa M. , Roig-Herrero Alejandro , Arjona-Valladares Antonio , Poza Jesús , Mañanas Miguel Ángel , Molina Vicente 
Published: January 2024

AbstractSchizophrenia has been associated with a reduced task-related modulation of cortical activity assessed through electroencephalography (EEG). However, to the best of our knowledge, no study so far has assessed the underpinnings of this decreased EEG modulation in schizophrenia. A possible substrate of these findings could be a decreased inhibitory function, a replicated finding in the field. In this pilot study, our aim was to explore the association between EEG modulation during a cognitive task and the inhibitory system function in vivo in a sample including healthy controls and patients with schizophrenia. We hypothesized that the replicated decreased task-related activity modulation during a cognitive task in schizophrenia would be related to a hypofunction of the inhibitory system. For this purpose, 27 healthy controls and 22 patients with schizophrenia (including 13 first episodes) performed a 3-condition auditory oddball task from which the spectral entropy modulation was calculated. In addition, cortical reactivity—as an index of the inhibitory function—was assessed by the administration of 75 monophasic transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex. Our results replicated the task-related cortical activity modulation deficit in schizophrenia patients. Moreover, schizophrenia patients showed higher cortical reactivity following transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex compared to healthy controls. Cortical reactivity was inversely associated with EEG modulation, supporting the idea that a hypofunction of the inhibitory system could hamper the task-related modulation of EEG activity.
Forensic age estimation of the knee by post-mortem DR, CT, and MR imaging: a comparative study
Authors: Khatam-Lashgari Apameh , Harving Mette Lønstrup , Villa Chiara , Lynnerup Niels , Larsen Sara Tangmose 
Published: January 2024

AbstractIt is believed by many that reference data for age estimation purposes must be imaging-modality specific. A study from our department has however proven otherwise. We therefore found it interesting to investigate this further by looking at the level of agreement between different imaging modalities. The aim of this study was to investigate the level of agreement between the three radiological modalities, computed tomography (CT), magnetic resonance imaging (MRI), and digital radiography (DR), in assessing the ossification of the epiphyses of the knee. A total of 34 deceased individuals of 10–25 years of age, brought in for a medicolegal autopsy at our department, were scanned by CT, MRI, and DR. The ossification stages of the three bones of the right knee, distal femoral, proximal tibial, and proximal fibular epiphysis were assessed using the established combined staging method by Schmeling et al. and Kellinghaus et al. Analysis of the results by Cohen’s weighted kappa showed a good agreement between CT and DR (K = 0.61–0.70), and MRI and DR (K = 0.68–0.79) but only moderate agreement between CT and MRI (K = 0.55–0.57). This leads us to conclude that different radiological images cannot be used interchangeably for age estimation purposes, so reference material needs to be imaging-modality specific. However, to make a more general conclusion research on a larger population is needed.
Real-world evidence of epidemiology, patient characteristics, and mortality in people with drug-resistant epilepsy in the United Kingdom, 2011–2021
Authors: Shankar Rohit , Marston Xiaocong Li , Danielson Vanessa , Do Rego Bronwyn , Lasagne Reginald , Williams Oliver , Groves Lara 
Published: January 2024

Abstract
Background
A third of people with epilepsy are drug resistant. People with drug-resistant epilepsy (DRE) have a higher risk of mortality and physical injuries than those who respond to anti-seizure medication (ASM). This study describes patient characteristics, comorbidities, and mortality in people with DRE in the UK.

Methods
The Clinical Practice Research Datalink was utilised to select people with DRE prescribed a third ASM between 1 January 2011 and 31 March 2021. Annual incidence and prevalence of DRE, patient characteristics, comorbidities, and mortality rates were analysed. Subgroup analysis was performed by age, sex, presence of intellectual disabilities and time from epilepsy diagnosis to DRE.

Results
A total of 34,647 people with DRE were included (mean ± SD age 42.68 ± 23.59 years, 52.6% females). During the study period, annual DRE incidence ranged from 1.99% to 3.12%. As of 31 March 2021, DRE prevalence was 26.6% (95% confidence interval [CI] 26.3%–26.8%). A greater proportion of people with DRE resided in the most deprived regions, with 21.1% and 16.7% in the top two quintiles of the Index of Multiple Deprivation respectively, compared to < 15% in the three less deprived regions. All-cause mortality ranged from 3,687 to 4,802 per 100,000 persons with DRE, four times higher than that in the general population in the UK. Variations existed across subgroups.

Conclusions
Considerable disease burden was observed in people with DRE in the UK. The findings emphasise the importance of early DRE diagnosis and appropriate disease management in people who develop DRE.
Studying the topology of peroxisomal acyl-CoA synthetases using self-assembling split sfGFP
Authors: Chornyi Serhii , Koster Janet , IJlst Lodewijk , Waterham Hans R. 
Published: January 2024

AbstractPeroxisomes are membrane-bounded organelles that contain enzymes involved in multiple lipid metabolic pathways. Several of these pathways require (re-)activation of fatty acids to coenzyme A (CoA) esters by acyl-CoA synthetases, which may take place inside the peroxisomal lumen or extraperoxisomal. The acyl-CoA synthetases SLC27A2, SLC27A4, ACSL1, and ACSL4 have different but overlapping substrate specificities and were previously reported to be localized in the peroxisomal membrane in addition to other subcellular locations. However, it has remained unclear if the catalytic acyl-CoA synthetase sites of these enzymes are facing the peroxisomal lumen or the cytosolic side of the peroxisomal membrane. To study this topology in cellulo we have developed a microscopy-based method that uses the previously developed self-assembling split superfolder (sf) green fluorescent protein (GFP) assay. We show that this self-assembling split sfGFP method can be used to study the localization as well as the topology of membrane proteins in the peroxisomal membrane, but that it is less suited to study the location of soluble peroxisomal proteins. With the method we could demonstrate that the acyl-CoA synthetase domains of the peroxisome-bound acyl-CoA synthetases SLC27A2 and SLC27A4 are oriented toward the peroxisomal lumen and the domain of ACSL1 toward the cytosol. In contrast to previous reports, ACSL4 was not found in peroxisomes.
Energetics of sinusoidal exercise below and across critical power and the effects of fatigue
Authors: Borrelli Marta , Shokohyar Sheida , Rampichini Susanna , Bruseghini Paolo , Doria Christian , Limonta Eloisa Guglielmina , Ferretti Guido , Esposito Fabio 
Published: January 2024

Abstract
Purpose
Previous studies investigating sinusoidal exercise were not devoted to an analysis of its energetics and of the effects of fatigue. We aimed to determine the contribution of aerobic and anaerobic lactic metabolism to the energy balance and investigate the fatigue effects on the cardiorespiratory and metabolic responses to sinusoidal protocols, across and below critical power (CP).

Methods
Eight males (26.6 ± 6.2 years; 75.6 ± 8.7 kg; maximum oxygen uptake 52.8 ± 7.9 ml·min−1·kg−1; CP 218 ± 13 W) underwent exhausting sinusoidal cycloergometric exercises, with sinusoid midpoint (MP) at CP (CPex) and 50 W below CP (CP-50ex). Sinusoid amplitude (AMP) and period were 50 W and 4 min, respectively. MP, AMP, and time-delay (tD) between mechanical and metabolic signals of expiratory ventilation ($${\dot{V}}_{E}$$

V
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E

), oxygen uptake ($${\dot{V}}_{{{\text{O}}}_{2}}$$

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2

), and heart rate ($${f}_{H}$$

f
H

) were assessed sinusoid-by-sinusoid. Blood lactate ([La−]) and rate of perceived exertion (RPE) were determined at each sinusoid.

Results
$${\dot{V}}_{{{\text{O}}}_{2}}$$

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AMP was 304 ± 11 and 488 ± 36 ml·min−1 in CPex and CP-50ex, respectively. Asymmetries between rising and declining sinusoid phases occurred in CPex (36.1 ± 7.7 vs. 41.4 ± 9.7 s for $${\dot{V}}_{{{\text{O}}}_{2}}$$

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tD up and tD down, respectively; P < 0.01), with unchanged tDs. $${\dot{V}}_{{{\text{O}}}_{2}}$$

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MP and RPE increased progressively during CPex. [La−] increased by 2.1 mM in CPex but remained stable during CP-50ex. Anaerobic contribution was larger in CPex than CP-50ex.

Conclusion
The lower aerobic component during CPex than CP-50ex associated with lactate accumulation explained lower $${\dot{V}}_{{{\text{O}}}_{2}}$$

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AMP in CPex. The asymmetries in CPex suggest progressive decline of muscle phosphocreatine concentration, leading to fatigue, as witnessed by RPE.
Maximum Anterior Tongue Strength and Maximum Lip Strength in Healthy Spanish Adults: A Proposal of Reference Values
Authors: Marín-Bernard Enrique , Ruiz-López María Dolores , Gómez-Pozo Basilio , Artacho Reyes 
Published: January 2024

AbstractAdequate tongue and lip strengths are needed for normal speech, chewing, and swallowing development. The aim was to evaluate the influence of sex and age on maximum anterior tongue strength (MTS) and maximum lip strength (MLS) in healthy Spanish adults to establish reference values that can be used in clinical practice.This cross-sectional study comprises 363 subjects (mean age 47.5 ± 20.7 years) distributed by sex (258 women and 105 men) and across three age groups: Young (18–39 years), middle-aged (40–59 years), and older adults (> 59 years). MTS and MLS were determined using the Iowa Oral Performance Instrument (IOPI). The mean MTS was 49.63 ± 13.81 kPa, regardless of sex, and decreased with age. The mean MLS was statistically higher for men (28.86 ± 10.88 kPa) than for women (23.37 ± 6.92 kPa, p = 0.001), regardless of age.This study provides the first reference values for the standardized measurement of MTS and MLS in a healthy adult Spanish-speaking population using the IOPI.
Anemia diagnosis and therapy in malignant diseases: implementation of guidelines—a representative study
Authors: Link Hartmut , Kerkmann Markus , Holtmann Laura , Detzner Markus 
Published: January 2024

Abstract
Purpose
Anemia in cancer should be diagnosed and treated according to guideline recommendations. The implementation of ESMO and German guidelines and their effect on anemia correction was analyzed.

Methods
This retrospective epidemiological study, representative for Germany, analyzed data on anemia management of cancer patients with anemia ≥ grade 2. The Guideline Adherence Score (GLAD) for diagnosis (GLAD-D) and therapy (GLAD-T) was defined as follows: 2 points for complete, 1 point for partial, 0 point for no adherence.

Results
Data were analyzed for 1046 patients. Hb levels at diagnosis of anemia were 8–10 g/dL in 899 (85.9%) patients, 7–8 g/dL in 92 (8.7%), and < 7 g/dL (5.0%) in 52. Transferrin saturation was determined in 19% of patients. Four hundred fifty-six patients received RBC (43.6%), 198 (18.9%) iron replacement, 106 (10.1%) ESA, and 60 (5.7%) vitamin B12 replacement. 60.6% of patients receiving iron replacement were treated intravenously and 39.4% were treated orally. Two hundred eighty-eight (36.6%) of 785 patients receiving transfusions had no guideline-directed indication. GLAD-D was 2 in 310 patients (29.6%), 1 in 168 (16.1%), and 0 in 568 (54.3%). GLAD-T was 2 in 270 patients (25.8%), 1 in 320 patients (30.6%), and 0 in 456 patients (43.6%). Higher GLAD-D significantly correlated with higher GLAD-T (τB = 0.176, p < 0.001). GLAD-T 2 was significantly associated with greater Hb increase than GLAD-T 0/1 (p < 0.001) at 28 days (10.2 vs. 9.7 g/dL) and at 2 months (10.4 vs. 9.9 g/dL).

Conclusions
Anemia assessment is inadequate, transfusion rates too high, and iron and ESA therapy too infrequent.

Trial registration
ClinicalTrials.gov, NCT05190263, date: 2022–01-13.
Use of artificial neural networks in architecture: determining the architectural style of a building with a convolutional neural networks
Authors: Cantemir Ece , Kandemir Ozlem 
Published: January 2024

AbstractThe discussion of "can machines think?" which started with the invention of the modern computer, brought along the question of "can machines design?" by researchers in the design field. These developments in information technologies have also affected the architecture. Artificial intelligence applications are encountered in many areas such as pricing estimation, energy conservation security systems of buildings, ventilation systems, user-oriented interactive design solutions, computer-aided programs used in the plan production phase and design process. When the literature on artificial intelligence applications in the architecture is reviewed, it can be seen that it generally includes shape grammars, graph theory, decision trees, constraint-based models, machine learning methods, RNN (Recursive Neural Networks), CNN (Convolutional Neural Network) and GAN (Generative Adversarial Network) algorithms. In this study, the use of artificial intelligence algorithms in architecture was examined, and an example was designed to determine the architectural structures of different periods by using CNN (Convolutional Neural Network). In the study, the open source TensorFlow library developed by Google and the Python programming language were used. Employing a statistical approach and utilizing convolutional neural networks (CNNs), a study has successfully classified the current flow patterns of buildings based on datasets comprising facades of Gothic, Modern, and Deconstructivist architectural styles. The findings demonstrate the efficacy of CNNs in accurately distinguishing the intricate details of diverse architectural styles. Recognizing elements from different periods using the CNN algorithm can examine not only individual buildings but also the relationship of buildings with their environments. It can also gain an important place in the field of conservation of the architectural discipline. The historical processes, aesthetic features and changes of protected buildings can be learned with the CNN algorithm and can guide restoration decisions. As a result of the study, the employed CNN-based model can correctly classify structures with 84.66% accuracy rate.
Micromotor-based dual aptassay for early cost-effective diagnosis of neonatal sepsis
Authors: Gordón Pidal José M. , Arruza Luis , Moreno-Guzmán María , López Miguel Ángel , Escarpa Alberto 
Published: January 2024

AbstractGiven the long-life expectancy of the newborn, research aimed at improving sepsis diagnosis and management in this population has been recognized as cost-effective, which at early stages continues to be a tremendous challenge. Despite there is not an ideal-specific biomarker, the simultaneous detection of biomarkers with different behavior during an infection such as procalcitonin (PCT) as high specificity biomarker with one of the earliest biomarkers in sepsis as interleukin-6 (IL-6) increases diagnostic performance. This is not only due to their high positive predictive value but also, since it can also help the clinician to rule out infection and thus avoid the use of antibiotics, due to their high negative predictive value. To this end, we explore a cutting-edge micromotor (MM)-based OFF–ON dual aptassay for simultaneous determination of both biomarkers in 15 min using just 2 μL of sample from low-birth-weight neonates with gestational age less than 32 weeks and birthweight below 1000 g with clinical suspicion of late-onset sepsis. The approach reached the high sensitivities demanded in the clinical scenario (LODPCT = 0.003 ng/mL, LODIL6 = 0.15 pg/mL) with excellent correlation performance (r > 0.9990, p < 0.05) of the MM-based approach with the Hospital method for both biomarkers during the analysis of diagnosed samples and reliability (Er < 6% for PCT, and Er < 4% for IL-6). The proposed approach also encompasses distinctive technical attributes in a clinical scenario since its minimal sample volume requirements and expeditious results compatible with few easy-to-obtain drops of heel stick blood samples from newborns admitted to the neonatal intensive care unit. This would enable the monitoring of both sepsis biomarkers within the initial hours after the manifestation of symptoms in high-risk neonates as a valuable tool in facilitating prompt and well-informed decisions about the initiation of antibiotic therapy.These results revealed the asset behind micromotor technology for multiplexing analysis in diagnosing neonatal sepsis, opening new avenues in low sample volume-based diagnostics.
Graphical Abstract