bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of surgical complications in boys with hypospadias: data from an international registry
Authors: Scougall Kathryn , Bryce Jillian , Baronio Federico , Boal Rachel L , Castera Jose Roberto , Castro Sebastián , Cheetham Tim , Costa Eduardo Corrêa , Darendeliler Feyza , Davies Justin H , Dirlewanger Mirjam , Gazdagh Gabriella , Globa Evgenia , Guerra-Junior Gil , Guran Tulay , Herrmann Gloria , Holterhus Paul-Martin , Akgül Ahsen Karagözlü , Markosyan Renata , McElreavey Kenneth , Miranda Marcio Lopes , Nordenstrom Anna , O’Toole Stuart , Poyrazoglu Sukran , Russo Gianni , Schwitzgebel Valerie , Stancampiano Marianna , Steigert Michael , Ahmed S Faisal , Lucas-Herald Angela K 
Published: October 2023

BackgroundComplications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.MethodsData from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates.ResultsOf the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications.ConclusionsBoys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.
Spin 12 from gluons
Authors: Balachandran A. P. 
Published: October 2023

The theta vacuum in QCD is obtained from the standard vacuum, after twisting by the exponential of the Chern–Simons term. However, a question remains–what is the quantum operator [Formula: see text] for winding number 1? We construct this operator [Formula: see text] in this note. The Poincaré rotation generators commute with it only if they are augmented by the spin [Formula: see text] representation of the Lorentz group, coming from large gauge transformations. This result is analogous to the well-known “spin-isopin” mixing result due to Jackiw and Rebbi [Phys. Rev. Lett. 36, 1116 (1976)], and Hasenfratz and ’t Hooft [Phys. Rev. Lett. 36, 1119 (1976)]. There is a similar result in fuzzy physics literature of Balachandran, Kurkcuoglu and Vaidya [Lectures on Fuzzy and Fuzzy Susy Physics (World Scientific Publishing Company, 2007)]. This shows that states can drastically affect representations of observables. This fact is further shown by charged states dressed by infrared clouds. Following Mund, Rehren and Schroer [arXiv:hep-th/2109.10342], we find that Lorentz invariance is spontaneously broken in these sectors. This result has been extended earlier to QCD (Balachandran, Nair, Pinzul, Reyes-Lega and Vaidya [arXiv:2112.08631 [hep-th]], reference given in the Final Remarks) where even the global QCD group is shown to be broken. It is argued that the escort fields of Mund, Rehren and Schroer [arXiv:hep-th/2109.10342] are the Higgs fields for Lorentz and color breaking. They are string-localized fields where the strings live in a union of de Sitter spaces. Their oscillations and those of the infrared cloud can generate the associated Goldstone modes.
Dark energy black holes with intermediate masses at high redshifts: An earlier generation of quasars and observations
Authors: Singh Anupam 
Published: October 2023

Dark energy is the largest fraction of the energy density of our universe — yet it remains one of the enduring enigmas of our times. Here we show that dark energy can be used to solve 2 tantalizing mysteries of the observable universe. We build on existing models of dark energy linked to neutrino masses. In these models, dark energy can undergo phase transitions and form black holes. Here we look at the implications of the family structure of neutrinos for the phase transitions in dark energy and associated peaks in black hole formation. It has been previously shown that one of these peaks in black hole formation is associated with the observed peak in quasar formation at redshifts [Formula: see text]. Here, we predict that there will also be an earlier peak in the dark energy black holes at high redshifts [Formula: see text]. These dark energy black holes formed at high redshifts are Intermediate Mass Black Holes (IMBHs). These dark energy black holes at large redshift can help explain both the EDGES observations and the observations of large Supermassive Black Holes (SMBHs) at redshifts of 7 or larger. This work directs us to actively look for these dark energy black holes at these high redshifts as predicted here through targeted searches for these black holes at the redshifts [Formula: see text] near 18. There is a slight dependence of the location of the peak on the lightest neutrino mass. This may enable a measurement of the lightest neutrino mass — something which has eluded us so far. Finding these dark energy black holes of Intermediate Mass should be within the reach of upcoming observations — particularly with the James Webb Space Telescope — but perhaps also through the use of other innovative techniques focusing specifically on the redshifts [Formula: see text] around 18.
Associations between Differential Aging and Lifestyle, Environment, Current, and Future Health Conditions: Findings from Canadian Longitudinal Study on Aging
Authors: Song Yipeng , Liu Yang S. , Talarico Fernanda , Zhang Yanbo , Hayward Jake , Wang Mengzhe , Stroulia Eleni , Dixon Roger A. , Greiner Russell , Li Xinmin , Greenshaw Andrew , Jie Sui , Cao Bo 
Published: October 2023

Introduction: An aging population will bring a pressing challenge for the healthcare system. Insights into promoting healthy longevity can be gained by quantifying the biological aging process and understanding the roles of modifiable lifestyle and environmental factors, and chronic disease conditions. Methods: We developed a biological age (BioAge) index by applying multiple state-of-art machine learning models based on easily accessible blood test data from the Canadian Longitudinal Study of Aging (CLSA). The BioAge gap, which is the difference between BioAge index and chronological age, was used to quantify the differential aging, i.e., the difference between biological and chronological age, of the CLSA participants. We further investigated the associations between the BioAge gap and lifestyle, environmental factors, and current and future health conditions. Results: BioAge gap had strong associations with existing adverse health conditions (e.g., cancers, cardiovascular diseases, diabetes, and kidney diseases) and future disease onset (e.g., Parkinson’s disease, diabetes, and kidney diseases). We identified that frequent consumption of processed meat, pork, beef, and chicken, poor outcomes in nutritional risk screening, cigarette smoking, exposure to passive smoking are associated with positive BioAge gap (“older” BioAge than expected). We also identified several modifiable factors, including eating fruits, legumes, vegetables, related to negative BioAge gap (“younger” BioAge than expected). Conclusions: Our study shows that a BioAge index based on easily accessible blood tests has the potential to quantify the differential biological aging process that can be associated with current and future adverse health events. The identified risk and protective factors for differential aging indicated by BioAge gap are informative for future research and guidelines to promote healthy longevity.
Behavioral drowsiness detection system execution based on digital camera and MTCNN deep learning
Authors: Majeed Ali Hassan , Hussein Ali Adnan , A. Al-Hilali Aqeel , Sameer Jabbar Mohanad , Ghasemi Safiye , G. S. Al-Safi Mohammed 
Published: October 2023

Drowsy driving is a major cause of road accidents worldwide, necessitating the development of effective drowsiness detection systems. Each year, there are more accidents and fatalities than ever before for a variety of causes. For instance, there were 22,952 fatalities and 79,545 injuries as a result of nearly 66,500 vehicle accidents in the last 10 years. In this paper, we propose a novel approach for detecting drowsiness based on behavioral cues captured by a digital camera and utilizing the multi-task cascaded convolutional neural network (MTCNN) deep learning algorithm. A high-resolution camera records visual indications like closed or open eye movement to base the technique on the driver's behavior. In order to measure a car user's weariness in the present frame of reference, eyes landmarks are evaluated, which results in the identification of a fresh constraint known as "eyes aspect ratio." A picture with a frame rate of 60 frames per second (f/s) and a resolution of 4,320 eyeballs was used. The accuracy of sleepiness detection was more than 99.9% in excellent lighting and higher than 99.8% in poor lighting, according to testing data. The current study did better in terms of sleepiness detection accuracy than a lot of earlier investigations.
Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study
Authors: Sleight Emilie , Stringer Michael S. , Clancy Una , Arteaga Carmen , Jaime Garcia Daniela , Hewins Will , Jochems Angela C.C. , Hamilton Olivia K.L. , Manning Cameron , Morgan Alasdair G. , Locherty Rachel , Cheng Yajun , Liu Xiaodi , Zhang Junfang , Hamilton Iona , Jardine Charlotte , Brown Rosalind , Sakka Eleni , Kampaite Agniete , Wiseman Stewart , Valdés-Hernández Maria C. , Chappell Francesca M. , Doubal Fergus N. , Marshall Ian , Thrippleton Michael J. , Wardlaw Joanna M. 
Published: October 2023

BACKGROUND:
Cerebrovascular reactivity (CVR) is inversely related to white matter hyperintensity severity, a marker of cerebral small vessel disease (SVD). Less is known about the relationship between CVR and other SVD imaging features or cognition. We aimed to investigate these cross-sectional relationships.

METHODS:
Between 2018 and 2021 in Edinburgh, we recruited patients presenting with lacunar or cortical ischemic stroke, whom we characterized for SVD features. We measured CVR in subcortical gray matter, normal-appearing white matter, and white matter hyperintensity using 3T magnetic resonance imaging. We assessed cognition using Montreal Cognitive Assessment. Statistical analyses included linear regression models with CVR as outcome, adjusted for age, sex, and vascular risk factors. We reported regression coefficients with 95% CIs.

RESULTS:

Of 208 patients, 182 had processable CVR data sets (median age, 68.2 years; 68% men). Although the strength of association depended on tissue type, lower CVR in normal-appearing tissues and white matter hyperintensity was associated with larger white matter hyperintensity volume (B
NAWM
=−0.0073 [95% CI, −0.0133 to −0.0014] %/mm Hg per 10-fold increase in percentage intracranial volume), more lacunes (B
NAWM
=−0.00129 [95% CI, −0.00215 to −0.00043] %/mm Hg per lacune), more microbleeds (B
NAWM
=−0.00083 [95% CI, −0.00130 to −0.00036] %/mm Hg per microbleed), higher deep atrophy score (B
NAWM
=−0.00218 [95% CI, −0.00417 to −0.00020] %/mm Hg per score point increase), higher perivascular space score (B
NAWM
=−0.0034 [95% CI, −0.0066 to −0.0002] %/mm Hg per score point increase in basal ganglia), and higher SVD score (B
NAWM
=−0.0048 [95% CI, −0.0075 to −0.0021] %/mm Hg per score point increase). Lower CVR in normal-appearing tissues was related to lower Montreal Cognitive Assessment without reaching convention statistical significance (B
NAWM
=0.00065 [95% CI, −0.00007 to 0.00137] %/mm Hg per score point increase).

CONCLUSIONS:
Lower CVR in patients with SVD was related to more severe SVD burden and worse cognition in this cross-sectional analysis. Longitudinal analysis will help determine whether lower CVR predicts worsening SVD severity or vice versa.

REGISTRATION:

URL:
https://www.isrctn.com
; Unique identifier: ISRCTN12113543.
Decarbonising the Shipping Industry: A Status Report
Authors: Handl Günther 
Published: October 2023

Abstract
Against the background of an escalating climate crisis, this article provides an overview of the present status of international regulatory efforts addressing greenhouse gas (GHG) emissions from ships. It does so by tracing the evolution of mitigation policies and regulations and examining their adequacy, practicability as well as equity and fairness. Its principal focus is on reducing GHG emissions from ships themselves as the most direct and effective approach to improving the shipping industry’s climate profile. International shipping, as an intrinsically globally operating industry, ultimately requires consistency, if not uniformity, in regulation which only a global regime can provide. The article therefore focuses primarily on efforts by the international community at large, specifically by the International Maritime Organization, to respond to the climate crisis and to ensure that the shipping industry decarbonises in a timely as well just and fair manner.
Implementation of hospital-based sickle cell newborn screening and follow-up programs in Haiti
Authors: Alvarez Ofelia A. , St Victor Dély Nora , Paul Hanna Michele , Saint Fleur Rony , Cetoute Marie , Metalonis Sarah , Hustace Tally , Brown Eric C. , Marcelin Louis Herns , Muscadin Emanise , Eveillard Ronald , Lerebours Emmeline 
Published: October 2023

Abstract
One in 120 children are born with sickle cell disease (SCD) in Haiti. However, health care challenges include isolated newborn screening (NBS) activities and lack of transcranial Doppler (TCD) ultrasound to assess stroke risk. The implementation activities of the Comparative Study of Children in Haiti and Miami with Sickle Cell Disease involved both NBS and TCD ultrasound implementations at 4 Haitian clinical sites. We hypothesized that hospital-based newborn SCD screening and follow-up programs would be feasible at Haiti. A traditional NBS laboratory method with dried blood samples was performed at 3 Port-au-Prince sites, and the traditional method plus point-of-care (POC) testing was used at the 2 northern sites. The rate of clinical follow-up for newborns with SCD as the outcome for the NBS intervention was compared with that of the NBS method. The NBS programs identified SCD in 0.77% of 8224 newborns over a 24-month period. In the rural hospital assigned to the combination screening, 56% of newborns identified with POC testing returned for follow-up, compared with 0% when POC was not available (P = .044). Newborns who tested positive for SCD and children aged &lt;6 years with SCD at the clinical sites were eligible for study follow-up. Accrual was successful: 165 participants (mean age, 42 months; 53% males; 93% hemoglobin SS) were recruited and received oral penicillin. TCD ultrasound screening was hampered by poor internet connections and trained staff leaving Haiti, with only 1 active site conducting screening. Despite challenges, the implementation of NBS and sickle cell programs in Haiti is feasible. We are in the process of understanding how to mitigate implementation limitations.
The impact of protective measures against COVID-19 on the wellbeing of residents in nursing homes and their relatives: a rapid review
Authors: Schneider P. , Abt M. , Cohen C. , Marmier N. , Ortoleva Bucher C. 
Published: October 2023

AbstractDuring the COVID-19 pandemic and compared to other population groups, older people were at a heightened risk of developing lethal disease symptoms. Thus, many countries put in place protective measures to protect this “at-risk” population, especially in nursing homes, to limit the number of infections. These measures consisted mostly in the absence of social gatherings, the impossibility for relatives to enter the nursing homes, limitations in group activities, and the ban of group-eating. Although these measures were helpful to mitigate the spread of the disease, they also induced long periods of social isolation for the residents of nursing homes. This could have impacted the wellbeing and quality of life of residents and their relatives, with a possible impact on the overall health of residents. We designed this rapid review to investigate the literature on the impact of COVID-19 protective measures in nursing homes on the quality of life, wellbeing and physical health of residents and their relatives. Our results showed that most of the articles included in the review, either using qualitative or quantitative methods, evidenced a detrimental impact of protective measures on resident’s and their relatives’ wellbeing. We argue that, in the event of a new pandemic similar to the COVID-19, protective measures should also take into account their psychological impact, and not only their physical impact.
Factors associated with subjective burden among informal caregivers of home-dwelling people with dementia: a cross-sectional study
Authors: Steinsheim Gunn , Malmedal Wenche , Follestad Turid , Olsen Bonnie , Saga Susan 
Published: October 2023

Abstract
Background
It is estimated that more than 57 million people have dementia worldwide, and it is one of the leading causes of care dependency in old age. Relatives and other informal caregivers are the most important support for individuals with dementia, but caring for a loved one with dementia may burden the caregiver. Caregiver burden may have adverse outcomes for both the informal caregiver and the care recipient, including decreased quality of life. Caregiver burden is associated with several factors concerning the informal caregiver, the care recipient, and relational and other contextual factors. The aim of this study was to explore which factors are associated with informal caregivers’ subjective burden when caring for individuals living at home with dementia.

Methods
This study was a cross-sectional survey among informal caregivers of home-dwelling individuals with dementia in all five geographical regions of Norway. There were 540 informal caregivers who participated, 415 of whom were included in the regression analyses. Caregivers’ subjective burden was assessed with the Relatives’ Stress Scale. Covariates included were classified into four levels: individual (twofold: informal caregiver and person with dementia), relational, community, and time. Linear multivariable regression analyses were used to identify associations between subjective burden and included factors.

Results
Several covariates were statistically significantly associated with subjective burden at the four levels. These covariates included self-rated health, mental distress, age, coping through resignation and denial, emotional and instrumental support, substance use, and humor at the informal caregiver level; behavioral and psychological symptoms of dementia, dementia severity, and degree of disability at the care recipient level; the extent of care, being the primary caregiver, and previous relationship satisfaction at the relational context level; and informal caregivers spending time with friends, leisure activities, social restriction, and knowledge of available health services at the community context level.

Conclusions
Informal caregivers’ mental distress and care recipients’ neuropsychiatric symptoms were the factors with the strongest association with subjective burden.
The Effect of Direct Oral Anticoagulant Therapy (DOACs) on oral surgical procedures: a systematic review
Authors: Darwish Ghassan 
Published: October 2023

Abstract
Background
Direct oral anticoagulants (DOACs) were developed to overcome the drawbacks of oral anticoagulants. However, not much has been discussed about the perioperative management of patients on DOACs during oral surgical procedures. Thus, we aim to determine the risk of perioperative and postoperative bleeding during oral surgical procedures in patients on DOACs.

Methods
A detailed literature search was performed to find potentially relevant studies using the Cochrane Library, Clinical Key, ClinicalTrials.gov, Google Scholar, Ovid, ScienceDirect, and Scopus. Every article available for free in English literature for the past 10 years, between 2012 and 2022, was searched.

Results
A total of 2792 abstracts were selected through a search strategy across various search engines. Based on inclusion and exclusion criteria, eleven clinical studies using DOACs as anticoagulants or studies comparing patients with and without DOACs under oral surgery procedures were found. The results were inconsistent and varied, with a few studies recommending DOAC administration with the bare minimum reported complications and others finding no statistically significant difference between discontinuation or continuation of drugs, especially across basic dental procedures.

Conclusion
Within the limitations of the study, it can be concluded that minor oral surgical procedures are safe for patients on DOAC therapy. However, the continuation or discontinuation of DOACs in patients undergoing oral surgical procedures remains controversial and requires further studies to extrapolate the results.
Third-wave cognitive behavioral therapies for caregivers of cancer patients: a scoping review
Authors: Hong Bomi , Yang Sora , Hyeon Sojeong , Kim Sojeong , Lee Jiyeon 
Published: October 2023

Abstract
Background
Cancer caregivers extend comprehensive support covering all aspects of patients’ daily lives. It has been reported that a significant proportion of cancer caregivers experience emotional distress. As one way to solve this problem, third-wave cognitive behavioral therapies (CBT), which involves integrating acceptance and mindfulness into cognitive‒behavioral therapy, has been applied to improve caregiver outcomes.

Methods
A scoping review was conducted based on the scoping review guidelines proposed by the Jonna Briggs Institute (JBI). The population was caregivers of cancer patients, the concept was third-wave CBT, and the context remained open. English and Korean publications published from 2001 to June 2022 were identified from PubMed, Embase, CINAHL, PsycINFO, Cochrane, Korea Med, and RISS.

Results
A total of 12 studies were included in this scoping review. Mindfulness-Based Stress Reduction (MBSR) and Acceptance and Commitment Therapy (ACT) was the most frequently applied intervention (n = 3, each). Among the components of third-wave CBT, ‘mindfulness’ was identified in all the studies reviewed (n = 12). Dyadic interventions comprised the majority (n = 9). Interventions using digital technologies such as mobile application/web page (n = 3), telephone (n = 3), and FaceTime (n = 2) have increased since 2017. Depression was the most frequently evaluated outcome (n = 8), followed by anxiety and mindfulness (n = 6, each).

Conclusions
The current review explored available third-wave CBT intervention studies for cancer caregivers and targeted outcomes. Most of the interventions were dyadic interventions and utilized mindfulness. Delivery methods were continuously updated with digital technologies. Further RCTs with robust research designs and a synthesis of the results of the trials would provide evidence about how to effectively apply third-wave CBTs for cancer caregivers.