bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology and formation mechanism of cracks in Al2O3–ZrO2 eutectic ceramics fabricated via laser powder bed fusion
Authors: Zhang Yang , Zhang Kai , Chen Dan , Liu Tingting , Xiong Zhiwei , Li Shurui , Li Fazhi , Zhu Zhiguang 
Published: December 2023

AbstractThe cracks in Al2O3–ZrO2 eutectic ceramics produced by laser powder bed fusion (LPBF) have a significant impact on their practical applications in various industries. In order to understand the factors influencing crack formation, a systematic study of the characterization and propagation of cracks in single‐track, multi‐track, and bulk samples by varying the process parameters has been carried out in this research. The results showed that parallel cracks can be healed by reducing the scanning spacing and scanning length. Additionally, it was found that using a modest scanning speed and a shorter length can minimize the accumulation of thermal stress, resulting in the suppress crack formation. Based on this conclusion, a crack‐free Al2O3–ZrO2 eutectic ceramic sample was finally obtained under the optimized parameters with the power of 100 W, the scanning speed of 100 mm/s, the hatch spacing of 100 μm, the scanning length of 3 mm, and the layer thickness of 50 μm. Additionally, three typical microstructures, including eutectic, cellular, and dendritic structures, were identified in the LPBF‐fabricated Al2O3–ZrO2 samples. The cellular microstructure showed improved crack inhibition capability due to the deflection and pinning effects. Cracks expand more easily in dendritic and eutectic microstructures, where anisotropy is more prominent.
Dielectric, energy storage, and charge–discharge properties of Yb‐modified Sr0.7Bi0.2TiO3 relaxor ferroelectric ceramic
Authors: Chen Jingjing , Zhao Peng , Si Feng , Zhang Shuren , Fang Zixuan , Tang Bin 
Published: December 2023

AbstractDielectric capacitors have been widely studied in advanced electronics systems due to their rapid discharge rate and high‐power density. Among them, relaxor ferroelectrics characterized by nanodomains possess broad application prospects as dielectric materials with high energy density and high efficiency. In this paper, the dielectric characteristics, energy storage performance, and charge–discharge behavior of rare‐earth Yb‐doped Sr0.7Bi0.2TiO3 ceramics are systematically investigated. The Yb‐doped SBT ceramics reduced the grain size, improved the insulation and thermal conductivity, and significantly improved the dielectric breakdown strength. Finally, a high recoverable energy density of 2.32 J/cm3 and an excellent energy storage efficiency of 92.2% were obtained at 300 kV/cm. In addition, pulsed charge–discharge tests show that Sr0.7Bi0.15Yb0.05TiO3 possesses a rapid discharge rate and high‐power density with superior thermal stability. Based on these outstanding characteristics, Sr0.7Bi0.15Yb0.05TiO3 exhibits promising applications in pulsed power systems.
Effects of phase transition on the dynamic discharge energy density of antiferroelectric ceramics
Authors: Wang Gang , Qiao Feng , Zhang Ling , Li Yingxuan , Wang Mengjiao , Zhu Qingshan , Xu Ran , Xu Zhuo , Feng Yujun , Wei Xiaoyong 
Published: December 2023

AbstractAntiferroelectrics (AFEs) are widely used for energy storage capacitors. At present, there are two methods to evaluate the energy density of AFE: the recoverable energy density Wre calculated by the low‐frequency P–E loop and the dynamic discharge energy density Wdis calculated by the fast discharge current. It has been widely observed that the value of Wdis is lower than Wre but less attention was paid to how to increase Wdis. Compared with Wre, the value of Wdis is closer to the energy density of AFE pulse capacitors in practical applications. In this work, the effects of phase transition properties on the dynamic discharge energy density were studied from the aspect of domain switching mobility. Compositions with P–E loop varying from “square” to “slant” were fabricated. It was found that in AFEs with “square” P–E loops, the recoverable energy density Wre was remarkably higher than Wdis. By modifying the P–E loops to long slim, the value of Wdis tended to be close to Wre, resulting in higher dynamic discharge energy efficiency. This indicates that by adjusting the P–E loop, higher Wdis can be achieved in AFE with lower Wre. The AFEs with long slim P–E loops also have faster discharge speeds, leading to higher power density. The outstanding fast discharge performance of AFEs with long slim P–E loops originated from their faster domain mobility and less viscous force during domain switching. This work provides a new approach to designing the AFEs energy storage materials by tuning their dynamic phase‐transition properties and domain mobility.
Interventions to support nurses as second victims of patient safety incidents: A qualitative study of nurse managers' perceptions
Authors: Järvisalo Paula , Haatainen Kaisa , Von Bonsdorff Monika , Turunen Hannele , Härkänen Marja 
Published: December 2023

AbstractAimsTo describe nurse managers' perceptions of interventions to support nurses as second victims of patient safety incidents and to describe the management of interventions and ways to improve them.DesignA qualitative study using interviews.MethodsA purposive sample of nurse managers (n = 16) recruited from three hospital districts in Finland was interviewed in 2021. The data were analysed using elements of inductive and deductive content analysis.ResultsThe study identified three main categories: (1) Management of second victim support, which contained three sub‐categories related to the nurse manager's role, support received by the nurse manager and challenges of support management; (2) interventions to support second victims included existing interventions and operating models; and (3) improving second victim support, based on the sub‐categories developing practices and developing an open and non‐blaming patient safety culture.ConclusionNurse managers play a crucial role in supporting nurses as second victims of patient safety incidents and coordinating additional support. Operating models for managing interventions could facilitate nurse managers' work and ensure adequate support for second victims. The support could be improved by increasing the awareness of the second victim phenomenon.Implications for the Profession and Patient CareMitigating the harmful effects of patient safety incidents can improve nurses' well‐being, reduce burden and attrition risks and positively impact patient safety.ImpactIncreasing awareness of the second victim phenomenon and coherent operation models would provide equal support for the nurses and facilitate nurse managers' work.Reporting MethodCOREQ checklist was used.What does this paper contribute to the wider global clinical community?

Nurse managers' role is significant in supporting the second victims and coordinating additional support.
Awareness of the second victim phenomenon and coherent operating models can secure adequate support for the nurses and facilitate nurse managers' work.
Re‐imagining of an undergraduate, second‐degree entry, accelerated nursing program's curriculum utilizing a postmodern, learner‐centred lens and a concept‐based framework
Authors: Pere Katalin , Manankil‐Rankin Louela , Zarins Baiba , Theriault Krysia , Lim Angie 
Published: December 2023

AbstractIntroductionIt is necessary to re‐imagine nursing curriculums utilizing a postmodern approach, as outdated teacher‐centred methods of nursing education with emphasis on memorization versus critical thinking no longer meet the needs of the contemporary learner and the current challenges of the healthcare environment. There is an explicit need to redesign nursing curriculums that are future‐oriented, adaptive and flexible and serve the learners' best interests.BackgroundDistilled from a decade of teaching experience in an undergraduate, second‐degree entry, accelerated nursing program, this paper describes the construction of a learner‐centred, postmodern, concept‐based nursing curriculum that aims to foster learners' inquiry skills, critical thinking, problem‐solving, and experiential learning—all which develop learners' autonomy, self‐direction, and lifelong learning. The objective is to foster learners' transformational and emancipatory learning and metacognition.DiscussionAn extensive review of the current trends, contemporary nursing knowledge for the past decade (2013–2023), and seminal literature on theories and frameworks paralleled with the review of current and future trends in Canadian and global health care, including the socio‐economic, politico and environmental contexts, led to the formulation of a concept‐based curriculum. Grounded in the constructivist paradigm, the curriculum applies interperetivist, critical, feminist, and indigenous lenses. The Strength‐Based Nursing framework was selected as the core guiding framework. The curriculum's four curricular themes and foundational pillars were adopted directly from the framework to provide a starting point for concept development. These initial themes were then juxtaposed with relevant nursing, and social theories, policies, and frameworks, ensuring a robust coverage of modern nursing knowledge and allowing for the core concepts of the curriculum to emerge. A total of 21 concepts and 192 sub‐concepts were developed.ConclusionImplications for future practice require nursing educators to receive support and professional development opportunities in developing skills and confidence in entering a classroom as co‐learners and facilitators.
Building upstream supplier capabilities for downstream customization: The role of collaboration capital
Authors: Madhavaram Sreedhar , Hall Kenneth , Ghosh Amit K. , Badrinarayanan Vishag 
Published: December 2023

AbstractOffering highly customized products and services is an attractive strategic option for firms in business‐to‐business (B2B) markets. However, as effective customization for downstream customers requires significant reliance on upstream suppliers, capabilities of upstream suppliers become central to firm strategies to produce customized offerings. Despite the importance of upstream supplier capabilities for downstream customization, there is a scarcity of research on how firms build their suppliers' capabilities for effective customization. Building on the foundations of research streams on customization, capabilities, and collaboration, this research tests a model which illustrates that (i) upstream supplier capabilities can result in positive customization outcomes for downstream markets and (ii) a firm's collaboration capital can build upstream supplier capabilities directly and also indirectly through supplier communication. Analyses of data collected from 189 organizations that extensively engage in downstream customization reveal the role of collaboration capital—conceptualized as a higher order factor with collaboration orientation, collaborative flexibility, and collaborative communication as first‐order dimensions—in building upstream supplier capabilities for downstream customization. We conclude with a delineation of the contributions, theoretical and practical implications, and limitations of this research.
Identification and validation of N7‐methylguanosine‐associated gene NCBP1 as prognostic and immune‐associated biomarkers in breast cancer patients
Authors: Li Jianrong , Zheng Lin , Song Liying , Dong Zhuanxia , Bai Wenqi , Qi Liqiang 
Published: December 2023

AbstractWe intend to evaluate the importance of N7‐methylguanosine (m7G) for the prognosis of breast cancer (BC). We gained 29 m7G‐related genes from the published literature and among them, 16 m7G‐related genes were found to have differential expression. Five differentially expressed genes (CYFIP1, EIF4E, EIF4E3, NCBP1 and WDR4) were linked to overall survival. This suggests that m7G‐related genes might be prognostic or therapeutic targets for BC patients. We put the five genes to LASSO regression analysis to create a four‐gene signature, including EIF4E, EIF4E3, WDR4 and NCBP1, that divides samples into two risky groups. Survival was drastically worsened in a high‐risk group (p < 0.001). The signature's predictive capacity was demonstrated using ROC (10‐year AUC 0.689; 10‐year AUC 0.615; 3‐year AUC 0.602). We found that immune status was significantly different between the two risk groups. In particular, NCBP1 also has a poor prognosis, with higher diagnostic value in ROC. NCBP1 also has different immune states according to its high or low expression. Meanwhile, knockdown of NCBP1 suppresses BC malignancy in vitro. Therefore, m7G RNA regulators are crucial participants in BC and four‐gene mRNA levels are important predictors of prognosis. NCBP1 plays a critical target of m7G mechanism in BC.
Multiple myeloma, haematologic malignancy and immunosuppressant and immunomodulatory medications are associated with sebaceous carcinoma, a pharmacovigilance study of the FDA adverse event reporting system
Authors: Jedlowski Patrick M. , DuPont Jason P. 
Published: December 2023

AbstractBackgroundSebaceous carcinoma (SC) is a rare skin cancer with significant associated morbidity and mortality. A known association exists between immunosuppression, in particular solid organ transplant patients (SOTR), and SC. However, the comparative reporting odds ratios (ROR) of different immunosuppressive medications and SC are incompletely defined.ObjectivesTo examine the relationship between SC and medication exposure in the FDA adverse event reporting system (FAERS).MethodsCase–control analyses were performed in FAERS from 1968 to 2021 to examine the reporting odds ratios (ROR) for SC.ResultsA total of 58 medication‐associated SC cases were identified. Immunosuppressant medication exposure was noted in 81% cases, with 20% total cases occurring in SOTR. Medications affecting the TNF‐ α ‐IL‐1‐IL‐2‐IL‐6 inflammatory axis were associated with elevated ROR for SC, including thalidomide (ROR 22.63, 95% CI 5.52–92.72), lenalidomide (ROR 10.86, 95% CI 4.93–23.94), cyclosporine, tacrolimus, tocilizumab, tofacitinib and ruxolitinib. Thirty per cent of cases of SC occurred with an associated haematologic malignancy or dyscrasia, including chronic lymphocytic leukaemia, non‐Hodgkin lymphoma and multiple myeloma.ConclusionsSC is associated with exposure to immunosuppressive medications, especially in SOTR patients. A significant portion of cases with SC had an associated haematology malignancy, in particular multiple myeloma with exposure to lenalidomide.
Alpelisib decreases nevocytes of congenital melanocytic nevi
Authors: Tomás‐Velázquez Alejandra , López‐Gutiérrez Juan Carlos , de Andrea Carlos , Reyes‐Múgica Miguel , Salgado Claudia M. , Redondo Pedro 
Published: December 2023

AbstractBackgroundMultiple, large or giant congenital melanocytic nevi (CMN) are uncommon and affected patients can show progressive growth and thickening, associate neurocutaneous melanocytosis or develop melanoma. Current treatment modalities are mostly complex surgeries that frequently do not solve the disease and its risks completely. Thus, investigation on new treatment options for CMN and its complications must continue. MAPK pathway inhibitors are being investigated, also targeting PI3K‐AKT. Omipalisib (PI3K inhibitor, with no indications approved yet) has been studied for CMN in vitro and in mice with promising results. However, alpelisib, a PI3K inhibitor approved with an adequate safety profile for patients with severe manifestations of PROS (PIK3CA‐Related Overgrowth Spectrum), had not yet been tested for CMN.ObjectiveTo evaluate the effect of alpelisib in nevocytes of congenital melanocytic nevi.MethodsNevomelanocytic tissue samples of 10 patients were collected prospectively and, following a previously reported preclinical ex vivo model, explants were placed in organotypic culture for 5 days, with or without alpelisib. Consecutively, tissue sections were stained and using scanned images with Qupath and ImageJ softwares, representative regions from the dermis were analysed (using Wilcoxon test and Spearman's correlation).ResultsWhen comparing alpelisib‐treated explants with respect to control explants, we found a decrease in cell density (p = 0.0273), in density of SOX10+‐cells (p = 0.0391) and also in the % of S‐100+ area (p = 0.0078), in alpelisib samples. The three markers showed a positive correlation (p < 0.05).ConclusionsThis study provides first‐time evidence that alpelisib induces nevocyte reduction in CMN from patient‐derived explants, probably inducted by autophagy. Alpelisib is an approved drug with an adequate safety profile used in another mosaicism affecting PI3K (PROS). Further studies are needed to evaluate its efficacy in treating CMN and potentially, their complications, either with local or systemic administration, alone or in combination.
Combined untargeted and targeted lipidomics approaches reveal potential biomarkers in type 2 diabetes mellitus cynomolgus monkeys
Authors: Tian Chao‐Yang , Yang Qun‐Hui , Lv Hai‐Zhou , Yue Feng , Zhou Fei‐Fan 
Published: December 2023

AbstractBackgroundThe significantly increasing incidence of type 2 diabetes mellitus (T2DM) over the last few decades triggers the demands of T2DM animal models to explore the pathogenesis, prevention, and therapy of the disease. The altered lipid metabolism may play an important role in the pathogenesis and progression of T2DM. However, the characterization of molecular lipid species in fasting serum related to T2DM cynomolgus monkeys is still underrecognized.MethodsUntargeted and targeted LC–mass spectrometry (MS)/MS‐based lipidomics approaches were applied to characterize and compare the fasting serum lipidomic profiles of T2DM cynomolgus monkeys and the healthy controls.ResultsMultivariate analysis revealed that 196 and 64 lipid molecules differentially expressed in serum samples using untargeted and targeted lipidomics as the comparison between the disease group and healthy group, respectively. Furthermore, the comparative analysis of differential serum lipid metabolites obtained by untargeted and targeted lipidomics approaches, four common serum lipid species (phosphatidylcholine [18:0_22:4], lysophosphatidylcholine [14:0], phosphatidylethanolamine [PE] [16:1_18:2], and PE [18:0_22:4]) were identified as potential biomarkers and all of which were found to be downregulated. By analyzing the metabolic pathway, glycerophospholipid metabolism was associated with the pathogenesis of T2DM cynomolgus monkeys.ConclusionThe study found that four downregulated serum lipid species could serve as novel potential biomarkers of T2DM cynomolgus monkeys. Glycerophospholipid metabolism was filtered out as the potential therapeutic target pathway of T2DM progression. Our results showed that the identified biomarkers may offer a novel tool for tracking disease progression and response to therapeutic interventions.
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1
Authors: Blumenreich Shani , Ben‐Yashar Doreen Padan , Shalit Tali , Kupervaser Meital , Milenkovic Ivan , Joseph Tammar , Futerman Anthony H. 
Published: December 2023

AbstractGaucher disease (GD) is a lysosomal storage disorder (LSD) caused by the defective activity of acid β‐glucosidase (GCase) which results from mutations in GBA1. Neurological forms of GD (nGD) can be generated in mice by intra‐peritoneal injection of conduritol B‐epoxide (CBE) which irreversibly inhibits GCase. Using this approach, a number of pathological pathways have been identified in mouse brain by RNAseq. However, unlike transcriptomics, proteomics gives direct information about protein expression which is more likely to provide insight into which cellular pathways are impacted in disease. We now perform non‐targeted, mass spectrometry‐based quantitative proteomics on brains from mice injected with 50 mg/kg body weight CBE for 13 days. Of the 5038 detected proteins, 472 were differentially expressed between control and CBE‐injected mice of which 104 were selected for further analysis based on higher stringency criteria. We also compared these proteins with differentially expressed genes (DEGs) identified by RNAseq. Some lysosomal proteins were up‐regulated as was interferon signaling, whereas levels of ion channel related proteins and some proteins associated with neurotransmitter signaling were reduced, as was cholesterol metabolism. One protein, transglutaminase 1 (TGM1), which is elevated in a number of neurodegenerative diseases, was absent from the control group but was found at high levels in CBE‐injected mice, and located in the extracellular matrix (ECM) in layer V of the cortex and intracellularly in Purkinje cells in the cerebellum. Together, the proteomics data confirm previous RNAseq data and add additional mechanistic understanding about cellular pathways that may play a role in nGD pathology.
How Integrated are Credit and Equity Markets? Evidence from Index Options
Authors: COLLIN‐DUFRESNE PIERRE , JUNGE BENJAMIN , TROLLE ANDERS B. 
Published: December 2023

ABSTRACTWe study the extent to which credit index (CDX) options are priced consistent with S&P 500 (SPX) equity index options. We derive analytical expressions for CDX and SPX options within a structural credit‐risk model with stochastic volatility and jumps using new results for pricing compound options via multivariate affine transform analysis. The model captures many aspects of the joint dynamics of CDX and SPX options. However, it cannot reconcile the relative levels of option prices, suggesting that credit and equity markets are not fully integrated. A strategy of selling CDX volatility yields significantly higher excess returns than selling SPX volatility.
Survival of temporomandibular total joint replacement: A systematic review and meta‐analysis
Authors: Lima Felipe Gomes Gonçalves Peres , Rios Larissa Gonçalves Cunha , Paranhos Luiz Renato , Vieira Walbert A. , Zanetta‐Barbosa Darceny 
Published: December 2023

AbstractBackgroundProsthetic total joint replacement has been incorporated as a treatment for complex temporomandibular disorder; however, the survival of those devices is unknown.ObjectiveTo assess the survival rate of the total temporomandibular joint (TMJ) prothesis and their main causes of failure.MethodsAn electronic search was conducted in eight databases until March 2023. Prospective studies reporting the survival rate of total TMJ prothesis with a minimum follow‐up of 12 months were included. Studies with partial TMJ prostheses or those no longer available on the market were excluded. Two reviewers assessed the individual risk of bias using the JBI Systematic Reviews for Quasi‐experimental studies tool. Meta‐analysis of proportions was conducted to summarise the survival rate, using 95% confidence intervals (CI). The GRADE approach assessed the certainty of the body of evidence.ResultsData from 320 patients were collected from six prospective studies. The number of prothesis losses varied from none to four. All studies presented sources of bias related to follow‐up description of the patients. The follow‐up time varied from 12 months to 21 years. In most of the studies, prosthesis failure occurred within the first 6 months after surgery due to infection. The overall survival of total TMJ protheses was 97% (95% CI: 95%; 99%), with low heterogeneity (I2 = 29%) and a very low certainty of evidence.ConclusionTMJ total prosthesis apparently is a safe procedure with a high survival rate and the evidence is very uncertain and presents important sources of bias.