bluuebunny/crossref_metadata_2025_split huggingface dataset:
ent‐Atisane Diterpenoids from Euphorbia helioscopia and Their Anti‐inflammatory Activities
Authors: Yang Hong‐Ying , Wen Mei‐Lian , Fu Shi‐Jing , Lu Yu‐Bo , Liu Ru‐Ling , Gao Kun , Chen Jian‐Jun 
Published: October 2023

AbstractPhytochemical investigation on the anti‐inflammatory fraction extracted from the whole plant of Euphorbia helioscopia L. led to the isolation of three new ent‐atisane diterpenoids (1–3) and five known analogues (4–8). The structures and absolute configurations of the new compounds were elucidated by comprehensive analysis of the NMR, MS, IR, ECD, and X‐ray crystallography. It is worth mentioning that compound 3 belongs to a rare class of ent‐atisane diterpenoid featuring a hydroxyl group at C‐9. Bioactivity investigation showed that compounds 4, 7, and 8 exhibited significant inhibitory effects on LPS‐induced NO production in a dose‐dependent manner, which indicates their anti‐inflammatory potential.
An inappropriately–appropriate ICD therapy: What is the mechanism and what interventions can be done?
Authors: Saplaouras Athanasios , Mililis Panagiotis , Kariki Ourania , Bazoukis George , Batsouli Athena , Antonakos Vasileios , Dragasis Stylianos , Patsiotis Ilias G. , Letsas Konstantinos P. , Efremidis Michael 
Published: October 2023

Key Clinical MessageR‐wave double counting is a rare cause of ventricular oversensing that can lead to inappropriate shocks. Optimizing device programming is essential for the avoidance of subsequent inappropriate therapies.AbstractR‐wave double counting is a rare cause of ventricular oversensing that can lead to inappropriate shocks. We present the case of a female patient, 52‐years‐old with a history of end‐stage hypertrophic cardiomyopathy. The patient suffered an implantable cardioverter‐defibrillator (ICD) shock. Cardiac device interrogation revealed ventricular tachycardia (VT) with a cycle length of 420 ms that was misclassified in the ventricular fibrillation (VF) zone owing to R‐wave double counting. Optimizing device programming is essential for the avoidance of subsequent inappropriate therapies. Possible therapeutic options are briefly presented in the case.
Tuberculosis manifesting with significant peripheral eosinophilia: A case report and review of literature
Authors: Damera Abhiram Rao , Gupta Prakash , Farooqi Shaheer , Sanker Vivek , Mathews Arpita Mariam , Pampati Shreya , Allala Manoj Reddy , Dave Tirth 
Published: October 2023

Key Clinical MessagePeripheral eosinophilia is a rare but potential sign of TB infection. Physicians should assess patients for TB, especially if they display related symptoms or risk factors, and consider TB as a differential diagnosis, especially in idiopathic cases.AbstractMillions of new tuberculosis (TB) cases are reported annually. Peripheral eosinophilia is rare in tuberculosis. We describe a rare case of tuberculosis with a high peripheral eosinophil count. A 9‐year‐old male presented with fever, cough, and respiratory discomfort for a month. The patient's cough did not respond to treatment, along with weight loss and a loss of appetite. A physical examination revealed cervical lymphadenopathy and bilateral lung crepitations. A hematological investigation showed a high eosinophil count of 25,920 cells per cubic millimeter and medical imaging abnormalities consistent with TB. Some malignancies, allergies, and parasitic infections produce peripheral eosinophilia. However, medical literature rarely discusses TB‐induced eosinophilia. Several studies attribute it to mycobacterium antigen hyperreactivity. Eosinophilic release of cytotoxic chemicals may cause tissue damage, and TB patients' eosinophil levels may fluctuate. This case report emphasizes the need to investigate TB in peripheral eosinophilia patients after ruling out other explanations. Our patient benefited from early detection and anti‐TB medication. More studies are required to investigate the causes of TB eosinophilia and its consequences. A detailed medical history and physical examination are essential to diagnose and treat atypical presentations of TB.
Histoplasmosis mimicking a tumor of the thumb in a patient with neurofibromatosis type I: A case report and review of the literature
Authors: Levine Joshua Marc , Manivel Juan , Luna Jeffery 
Published: October 2023

Key Clinical MessageWe describe an immunocompromised 73‐year‐old male with a history of neurofibromatosis type 1 (NF1) who presented with a lesion on the thumb concerning for malignancy that was found to be histoplasmosis. This unique case highlights the importance of a thorough history and a broad differential diagnosis in the management of new osteoarticular lesions.
Congenital lumbosacral junction kyphosis in an adult patient: A case report
Authors: Eslami Arvin , Chehrassan Mohammadreza , Alimoghadam Shaya , Shakeri Mohammadreza 
Published: October 2023

Key Clinical MessageRare lumbosacral junction kyphosis due to S1–S2 hemivertebra in a 40‐year‐old woman was managed surgically, improving neurological disturbances, and low back pain. Early intervention is vital for congenital anomalies.
HRAS mutation as a diagnostic molecular analysis for epithelial‐myoepithelial carcinoma of the parotid gland: A case report
Authors: Yasuda Taisei , Osaki Masami , Sugitani Masahiko 
Published: October 2023

Key Clinical MessageHRAS mutations are frequent genetic alterations in epithelial‐myoepithelial carcinoma, and they may be useful as ancillary molecular tests and predictive molecular tests for targeted therapy with tipifarnib.
Automatic peak annotation and area estimation of glycan map peaks directly from chromatograms
Authors: Hudnik Domen , Bohanec Naja , Drobnak Igor , Ernst Peter , Hanke Alexander , Horvat Matej , Innerbichler Franz , Mikelj Miha , Praper Tilen , Progar Vasja , Valenčič Nika , Omladič Matjaž 
Published: October 2023

AbstractThe present bottleneck in biosimilar bioprocess development has become evaluation of analytical results, due to recent advances in analytics, such as automated sample preparation and development of high‐throughput methods. Currently automated chromatogram integration and annotation is only efficient for simple chromatograms. In an ever more competitive field of biosimilars, this represents a serious drawback because chromatographic analytical methods that provide some of the most valuable physicochemical quality attributes of the product also require careful chromatogram integration and annotation. This work focuses on the glycan mapping analytical method as utilized in development of monoclonal antibody biosimilars, evaluating more than 2000 chromatograms spanning the life cycle of multiple biosimilar development projects. It proposes a modified workflow by implementing automatic machine learning algorithms to determine the proportion of specific relevant glycan species in a sample directly from the chromatogram. Data preparation and analysis is performed using a pipeline approach. Pipeline is a modular design of data processing where signal “travels” through various active modules in a series. Each module performs a specific function or transformation on the signal and propagates the transformed signal to the next module. The pipeline is designed in a way that modules can be independently improved and exchanged. Module functions currently implemented are chromatogram resampling by spline interpolation, baseline removal by asymmetric least squares, peak alignment using parametric time warping, and quantification of the relative proportion of a glycan species using partial least squares regression. Hyper‐parameters of the pipeline are then optimized using the Nelder–Mead method. The approach stands out for its ability to accommodate a broad landscape of samples, covering multiple different proteins in different stages of biosimilar development, analyzed using different adaptations of the glycan map analytical method. The pipeline presents an intuitive, flexible, and creatively simple method design capable of providing reliable results for a wide range of glycan species essential for biosimilar development. It enables transparent, faster, and less subjective evaluation of analytic raw data (from sample to result). Furthermore, our automated approach maintained an accuracy comparable with manual integration thus demonstrating its readiness for implementation in the conservative and highly regulated environment. The presented methodology reduces the cost and time of biosimilar development and should be applicable for any chromatogram‐based analytical method.
The presence of neutrophil extracellular traps in different forms of pyoderma gangrenosum
Authors: Ikeda Takaharu , Kawakami Tamihiro , Yokoyama Kae , Nishibata Yuka , Masuda Sakiko , Tomaru Utano , Ishizu Akihiro 
Published: October 2023

AbstractWe demonstrated that there were abundant neutrophil extracellular traps (NETs) in the skin biopsies from various types of pyoderma gangrenosum (PG), based on the observation of extended and compact areas of immunolabeling of MPO and Cit H3 proteins. We suggest that neutrophils could undergo an aberrant NET formation in the lesions of PG patients, in the vast majority of idiopathic PG. We did not detect NETs in the skin ulcers of an antiphospholipid syndrome patient with a similar appearance to classical ulcerative PG, while rich NETs were found in the various types of PG. These findings suggest that the presence of NETs in skin tissues could serve as a marker for making differential diagnoses of various types of PG from other similar conditions.
Terpene‐Functionalized Fluoroquinolones as Potential Antimicrobials: Synthesis and Properties
Authors: Izmest'ev Evgeniy S. , Pestova Svetlana V. , Kolesnikova Alena I. , Baidamshina Diana R. , Kayumov Airat R. , Rubtsova Svetlana A. 
Published: October 2023

AbstractThis study was the first to synthesize terpene‐containing conjugates of fluoroquinolones, ciprofloxacin and norfloxacin, and to evaluate their antibacterial activity against gram‐positive methicillin sensitive (MSSA) and methicillin resistant (MRSA) S. aureus, gram‐negative P. aeruginosa as well as antifungal activity against C. albicans. The ability of obtained fluoroquinolones to inhibit S. aureus growth was found to depend upon the presence of a linker separating the bulky terpene and fluoroquinolone fragments, and this activity diminished with increasing its length. The highest activity against MSSA was demonstrated by ciprofloxacin derivatives with campholenic (MIC 1 μg/mL) and 2‐(isobornan‐2‐yl‐sulfanyl)acetyl (MIC 0.5 μg/mL) substituents. The compound with the last fragment showed high activity against MRSA (MIC 8 μg/mL). The terpene‐functionalized norfloxacin derivatives generally proved to be less active than those containing ciprofloxacin fragment. Camphor‐10‐sulfonylamide derivative with the ciprofloxacin fragment was the only one of all compounds that showed high antifungal activity against C. albicans (8 μg/mL). The study presents data on docking fluoroquinolones to S. aureus DNA gyrase to explain the reasons for manifestation or disappearance of antibacterial activity. The cytotoxicity of fluoroquinolones that showed any antimicrobial activity was investigated against bovine primary lung cells, and they were found to be not toxic in most cases.
Decarbonizing university campuses: A business model for food waste management at Istanbul Technical University (İTÜ) Ayazağa Campus, Turkey
Authors: Maçin Kadriye Elif , Arıkan Osman Atilla , Altınbaş Mahmut , Damgaard Anders 
Published: October 2023

AbstractFood waste is a significant environmental issue today, as it contributes to depleting natural resources and greenhouse gas emissions from improper management. To address this, alternative food waste management and recovery strategies must be developed to promote nutrient recirculation and move towards decarbonization. University campuses could play a crucial role in pioneering such strategies, through pilot studies and implementation of effective waste management. The aim of this study is to devise a food waste management strategy that provides a more circular and decarbonized economy. A case example was developed based on ITU Ayazağa Campus, Turkey, with annual separated food waste of 577 tonne per year. A Life Cycle Assessment was conducted using the EASETECH software. Four scenarios were evaluated: anaerobic digestion, composting, incineration, and landfill. Of these, incineration resulted in the highest CO2‐eq savings, but lacked decoupling and circularity of resources. Conversely, anaerobic digestion demonstrated the highest circularity and lowest toxicity. Based on these findings, anaerobic digestion was selected for further investigation. Economic transactions for the anaerobic digestion system's business models were analyzed, including revenues, municipality fees, and operating costs. The new economic model is expected to align with circular economy strategies and promote stakeholder collaboration as a significant social outcome.
Carbon emission trading under the wings of black swans and green swans: Evidence from China
Authors: Guo Yunxia , Li Yujia , Wu Haitao , Hao Yu 
Published: October 2023

AbstractIn response to the potential green swans event in the future, China is adopting market‐oriented means to encourage green development, specifically through carbon emission trading schemes. At the same time, under the outbreak of the current global pandemic, it is equally important to consider the impact of black swan events. Therefore, this study aims to analyse the fluctuations in carbon emission trading prices under green and black swan events by utilizing daily data from seven carbon emission exchanges in China from 2017 to 2020. The analysis includes the construction of multiple regression models, PVAR models, and panel threshold models. Additionally, the study addresses the endogeneity problem by using instrumental variables. The findings of the study indicate that: (1) Rising temperatures will drive up the carbon emissions trading price, and this impact will persist over time. On the other hand, increased humidity levels and sunshine hours will reduce the carbon emissions trading price. Furthermore, there is a positive correlation between the increase in the price of primary energy and the increase in the carbon emissions trading price. (2) The spread of COVID‐19 has a restraining effect on the increase in temperature and will have a long‐term negative impact on the carbon emissions trading price. (3) The threshold effect concerning the prevalence of pandemics is recognized, which implies that the impact of the epidemic is staged and nonlinear. Overall, the results of this article highlight the importance of a reasonable response to both black swan and green swan events in order to enhance the efficiency of the current emission trading scheme.
Melatonin supplementation protects against traumatic colon injury by regulating SERPINA3N protein expression
Authors: Cao Bo , Gao Jing‐Wang , Zhang Qing‐Peng , Xu Xing‐Ming , Zhao Rui‐Yang , Li Hang‐Hang , Wei Bo 
Published: October 2023

AbstractTraumatic colon injury (TCI) is a typical injury with high mortality. Prolongation of the intervention time window is a potentially useful approach to improving the outcomes of TCI casualties. This study aimed to identify the pathological mechanisms of TCI and to develop effective strategies to extend the survival time. A semicircular incision was made to prepare a TCI model using C57BL/6 mice. An overview of microbiota dysregulation was achieved by metagenome sequencing. Protein expression reprogramming in the intestinal epithelium was investigated using proteomics profiling. The mice that were subjected to TCI died within a short period of time when not treated. Gut symbiosis showed abrupt turbulence, and specific pathogenic bacteria rapidly proliferated. The protein expression in the intestinal epithelium was also reprogrammed. Among the differentially expressed proteins, SERPINA3N was overexpressed after TCI modeling. Deletion of Serpina3n prolonged the posttraumatic survival time of mice with TCI by improving gut homeostasis in vivo. To promote the translational application of this research, the effects of melatonin (MLT), an oral inhibitor of the SERPINA3N protein, were further investigated. MLT effectively downregulated SERPINA3N expression and mitigated TCI‐induced death by suppressing the NF‐κB signaling pathway. Our findings prove that preventive administration of MLT serves as an effective regimen to prolong the posttraumatic survival time by restoring gut homeostasis perturbed by TCI. It may become a novel strategy for improving the prognosis of patients suffering from TCI.
Advances in Biginelli reaction: A comprehensive review
Authors: Chandravarkar Aravind , Aneeja Thaipparambil , Anilkumar Gopinathan 
Published: October 2023

AbstractThe Biginelli reaction, a conventional three‐component reaction provides 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones via one‐pot acid catalyzed cyclocondensation of an aldehyde, a β‐keto ester, and urea or thiourea. Dihydropyrimidones are well‐known scaffolds having a wide range of pharmacological activities. So far classical Biginelli reaction has witnessed several modification and studies are still continuing in this field to develop greener and efficient methodologies. In this review, we summarize the recent advances in Biginelli reaction covering literature from 2020 to 2023.
Factors associated with enteral autonomy after reanastomosis in infants with intestinal failure and ostomy: A descriptive cohort study
Authors: Patel Arjun D. , Casini Gina , Hagan Joseph L. , Debuyserie Anne , Vogel Adam M. , Gollins Laura , Hair Amy B. , Fernandes Caraciolo J. , Premkumar Muralidhar H. 
Published: October 2023

AbstractBackgroundTo determine variables associated with outcomes in infants with intestinal failure (IF) and ostomy following reanastomosis (RA).MethodsA single‐center, descriptive cohort study of 120 infants with IF and a stoma from January 2011 to December 2020 with subsequent RA during initial hospitalization. The primary outcome was achievement of enteral autonomy (EA) following RA. Other outcomes were duration of hospital stay, and mortality. Penalized logistic regression and linear regression were used for data analysis.ResultsThe median gestational age was 26 weeks, and the median birth weight was 890 g. Three infants died. The median duration between ostomy creation and RA was 80 days (interquartile range; 62.5, 100.5). For each additional day of discontinuity, the odds of EA decreased by 2% (odds ratio [OR] = 0.980; 95% confidence interval [CI]: 0.962, 0.999; P = 0.038), and death increased by 4.2% (OR = 1.042; 95% CI: 1.010, 1.075; P = 0.009). For each additional mL/kg/day of enteral feeds at RA, the odds of EA increased by 7.5% (OR = 1.075; 95% CI: 1.027, 1.126, P = 0.002) and duration of hospital stay decreased by 0.35 days (slope coefficient = −0.351; 95% CI: −0.540, −0.163; P < 0.001).ConclusionShorter duration of intestinal discontinuity and enteral nutrition before RA could positively influence EA and duration of stay in infants with IF and ostomy following RA.
Review of instrumental texture measurements as phenotypic tool to assess textural diversity of root, tuber and banana food products
Authors: Ayetigbo Oluwatoyin , Arufe Santiago , Kouassi Antonin , Adinsi Laurent , Adesokan Michael , Escobar Andres , Delgado Luis Fernando , Tanimola Abiola , Oroniran Oluyinka , Kendine Vepowo Cédric , Nakitto Mariam , Khakasa Elizabeth , Chijioke Ugo , Nowakunda Kephas , Ngoh Newilah Gérard , Otegbayo Bolanle , Akissoe Noel , Lechaudel Mathieu , Tran Thierry , Alamu Emmanuel Oladeji , Maziya‐Dixon Busie , Mestres Christian , Dufour Dominique 
Published: October 2023

AbstractRoots, tubers and bananas (RTBs) contribute immensely to food security and livelihoods in sub‐Saharan Africa, Asia and Latin America. The adoption of RTB genotypes in these regions relies on the interplay among agronomic traits, ease of processing and consumer preference. In breeding RTBs, until recently little attention was accorded key textural traits preferred by consumers. Moreover, a lack of standard, discriminant, repeatable protocols that can be used to measure the textural traits deter linkages between breeding better RTB genotypes and end user/consumer preferences. RTB products texture – that is, behaviour of RTB food products under unique deformations, such as disintegration and the flow of a food under force – is a critical component of these preferences. The preferences consumers have for certain product texture can be evaluated from expert sensory panel and consumer surveys, which are useful tools in setting thresholds for textural traits, and inform breeders on what to improve in the quality of RTBs. Textural characterization of RTBs under standard operating procedures (SOPs) is important in ensuring the standardization of texture measurement conditions, predictability of textural quality of RTBs, and ultimately definition of RTB food product profiles. This paper reviews current SOPs for the textural characterization of RTBs, including their various associated methods, parameters, challenges and merits. Case studies of texture characterized during development of SOPs and evaluation of texture of RTB populations are discussed, together with insights into key textural attributes and correlations between instrumental, sensory and consumer assessment of texture unique to various RTB food products. Hardness was considered a universal key textural attribute to discriminate RTBs. The review should provide adequate insight into texture of RTB food products and critical factors in their measurement. It aims to promote inclusion of texture in breeding pipelines by investigating which textural traits are prioritized by consumers, particularly since the inclusion of textural traits has recently gained prominence by breeders in improving RTBs. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Development of a method based on ATR‐FTIR spectroscopy to detect maple syrup adulterated with added syrups
Authors: Bilamjian Shaghig , Bahadi Mazen , Ismail Ashraf , Tremblay Charles , Bayen Stéphane 
Published: October 2023

AbstractBACKGROUNDFood adulteration is a global concern, whether it takes place intentionally or incidentally. In Canada, maple syrup is susceptible to being adulterated with cheaper syrups such as corn, beet, cane syrups, and many more due to its high price and economic importance.RESULTSIn this study, the use of attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectroscopy was investigated to detect maple syrups adulterated with 15 different sugar syrups at different concentration levels. The spectra were collected in the range of 4000–650 cm−1 in the absorbance unit. These spectra were used to build six libraries and three models. A method that is capable of performing a qualitative library search using a similarity search, which is based on the first derivative correlation search algorithm, was developed. This method was further evaluated and proved to be able to capture adulterated and reject non‐adulterated maple syrups, belonging to the color grades golden and amber maple syrups, with an accuracy of 93.9% and 92.3%, respectively. However, for the maple syrup belonging to the dark color grade, this method demonstrated low specificity of 33.3%, and for this reason it was only able to adequately detect adulterated samples from the non‐adulterated ones with an accuracy of 81.4%.CONCLUSIONThis simple and rapid method has strong potential for implementation in different stages of the maple syrup supply chain for early adulteration detection, particularly for golden and amber samples. Further evaluation and improvements are required for the dark color grade. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.