bluuebunny/crossref_metadata_2025_split huggingface dataset:
The hepcidin-ferroportin axis influences mitochondrial function, proliferation, and migration in pulmonary artery endothelial and smooth muscle cells
Authors: Issitt Theo , Toe Quezia K , Pedersen Sofia L , Shackshaft Thomas , Ghazaly Maziah Mohd , West Laura , Arnold Nadine D , Mahomed Abdul , Kagugube George W , Ramakrishnan Latha , Lawrie Allan , Wort S John , Quinlan Gregory J 
Published: October 2023

AbstractRationaleElevated circulating hepcidin levels have been reported in patients with pulmonary artery hypertension (PAH). Hepcidin has been shown to promote proliferation of human pulmonary artery smooth muscle cells (PASMCs) in vitro, suggesting a potential role in PAH pathogenesis. However, the role of human pulmonary artery endothelial cells (PAECs) as either a source of hepcidin, or the effect of hepcidin on PAECfunction has not previously been described.ObjectiveTo define the role of the hepcidin-ferroportin axis on the phenotype of pulmonary artery endothelial cellsMethods and resultsPAECs treated with hepcidin, or IL-6 were investigated for both ferroportin and hepcidin release and regulation with immunofluorescence, mRNA levels and cellular release assays. Effects of hepcidin on PASMC and PAEC mitochondrial function was investigated using immunofluorescence and seahorse assay. Migration and proliferation of PASMC treated with conditioned media from hPAEC treated with hepcidin was investigated using the Xcelligence system and other tools.PAECs express ferroportin; hepcidin treatment of PAECs results in mitochondrial iron accumulation and intracellular hepcidin biosynthesis and release. Conditioned media from hepcidin treated PAECs causes PASMCs to down regulate ferroportin expression whilst promoting migration and proliferation. Inhibition of hepcidin in PAEC conditioned media limits these responses. PASMC cellular and mitochondrial iron retention are associated with migratory and proliferative responses.ConclusionsThe Hepcidin-ferroportin axis is present and operational in PAECs. Modulation of this axis shows distinct differences in responses seen between PAECS and PASMCs. Stimulation of this axis in PAECS with hepcidin may well institute proliferative and migratory responses in PASMCs of relevance to pathogenesis of PAH offering a potential therapeutic target.
How do you manage? An auto-ethnographic inquiry into contemporary maternal labor
Authors: Baliç İlkay 
Published: October 2023

PurposeThis article tackles the intersection of mothering and labor through the author's own experience as a feminist mother/manager from Istanbul, Turkey. It aims to revisit the first years of motherhood, exploring the struggle to invent a peculiar maternal subjectivity in opposition and negotiation with the patriarchal institution of motherhood, the new definition of maternal labor in a highly digital, neoliberal context and the issue of marital fairness in a dual-income heterosexual marriage.Design/methodology/approachThe article presents an autoethnographic, retrospective and introspective inquiry into the first seven years of the author's mothering experience in order to offer an in-depth exploration of the various aspects of contemporary maternal labor.FindingsThe article shows how maternal labor has shifted in nature and expanded in scope in a contemporary non-Western context. It investigates the dissolution of the spatial, temporal and sensorial boundaries between the managerial labor dedicated to the workplace, and to the family. Highlighting the similarities of the two forms of labor, the article manifests the materiality, tangibility and visibility of maternal labor.Research limitations/implicationsFurther intersectional studies shall be beneficial to redefine maternal labor in different contexts.Practical implicationsDeparting and diverting from the terms “invisible labor” and “mental load”, the article suggests a shift in terminology to stress the multifaceted medley of managerial tasks mothers undertake today.Originality/valueThe article provides an original take on maternal labor through the first-hand experience of a middle-class, professional mother from Istanbul, Turkey.
A review on social segregation research: insights from bibliometric analysis
Authors: Zeini Nahed T. , Okasha Ahmed E. , Soliman Amal S. 
Published: October 2023

PurposeUsing bibliometrics, this study aims to explore the intellectual structure of social segregation research, key contributors, thematic areas and hotspot topics.Design/methodology/approachA bibliometric analysis was performed for more than 15,000 research papers listed in one of the famous, rich and widely used scientific databases: Web of Science (WoS). This review approach was used to identify social research hotspots on segregation, intellectual structure, borders and development trends. VOSviewer and Gephi software were employed for mapping and analysis.FindingsThe study indicates a marked increase in segregation research, particularly from a spatial/urban perspective. The study reveals the interrelationship between segregation and many other social concepts, such as social equality, cohesion, integration and inclusion. In conclusion, addressing the ramifications resulting from the multiple forms of segregation will help in implementing social policies and evaluating their impact on achieving inclusive social development in general and the 2030 agenda of Sustainable Development Goals (SDGs) in specific.Research limitations/implicationsThis study remains limited to the precision and thoroughness of the bibliographic data gained from WoS.Originality/valueThis study is valuable for readers to gain rich insights into the state of research on social segregation. It also provides ideas for future research that prospective authors and interested research and academic institutions can investigate.
The short and long‐term prognostic influences of liver grafts with high bilirubin levels at the time of organ recovery
Authors: Akabane Miho , Bekki Yuki , Imaoka Yuki , Inaba Yosuke , Kwong Allison J. , Esquivel Carlos O. , Melcher Marc L , Sasaki Kazunari 
Published: October 2023

AbstractBackgroundDonors with hyperbilirubinemia are often not utilized for liver transplantation (LT) due to concerns about potential liver dysfunction and graft survival. The potential to mitigate organ shortages using such donors remains unclear.MethodsThis study analyzed adult deceased donor data from the United Network for Organ Sharing database (2002–2022). Hyperbilirubinemia was categorized as high total bilirubin (3.0–5.0 mg/dL) and very high bilirubin (≥5.0 mg/dL) in brain‐dead donors. We assessed the impact of donor hyperbilirubinemia on 3‐month and 3‐year graft survival, comparing these outcomes to donors after circulatory death (DCD).ResultsOf 138 622 donors, 3452 (2.5%) had high bilirubin and 1999 (1.4%) had very high bilirubin levels. Utilization rates for normal, high, and very high bilirubin groups were 73.5%, 56.4%, and 29.2%, respectively. No significant differences were found in 3‐month and 3‐year graft survival between groups. Donors with high bilirubin had superior 3‐year graft survival compared to DCD (hazard ratio .83, p = .02). Factors associated with inferior short‐term graft survival included recipient medical condition in intensive care unit (ICU) and longer cold ischemic time; factors associated with inferior long‐term graft survival included older donor age, recipient medical condition in ICU, older recipient age, and longer cold ischemic time. Donors with ≥10% macrosteatosis in the very high bilirubin group were also associated with worse 3‐year graft survival (p = .04).DiscussionThe study suggests that despite many grafts with hyperbilirubinemia being non‐utilized, acceptable post‐LT outcomes can be achieved using donors with hyperbilirubinemia. Careful selection may increase utilization and expand the donor pool without negatively affecting graft outcome.
Hospital admissions among people with diabetes: A systematic review
Authors: Feleke Berhanu Elfu , Sacre Julian , Tomic Dunya , Huynh Quan , Shaw Jonathan E. , Magliano Dianna J. 
Published: October 2023

AbstractObjectiveTo describe the reasons for hospital admission among people with diabetes.MethodsWe searched Emcare, Embase, Medline and Google Scholar databases for population‐based studies describing the causes of hospitalisation among people with diabetes. We included articles published in English from 1980 to 2022. For each study, we determined the most frequent reasons for admission. Studies were assessed for quality using the Newcastle Ottawa quality assessment tool.Results6920 research articles were retrieved from the search of all sources. After screening the titles and abstracts of these, we reviewed the full text of 135 papers and finally included data from 42 studies. Admissions among the total diabetes were reported in 25 papers: 5 articles reported type 1 diabetes alone, 10 articles reported type 2 diabetes alone and the remaining 2 articles reported type 1 and type 2 diabetes separately. Among the 25 total and type 2 diabetes studies that reported the distribution of hospitalisations in broad categories, cardiovascular diseases (CVD) were the leading cause of admission in 19/25 (76%) of studies. Among the 19 studies that reported CVD admissions by subcategories, ischaemic or coronary heart disease was the leading subtype of CVD in 58% of studies. The other common causes of admissions were infections, renal disorders, endocrine, nutritional, metabolic and immunity disorders. In people with type 1 diabetes, acute diabetes complications were the leading cause of admission.ConclusionCVD are the leading cause of hospital admission for people with diabetes, with ischaemic or coronary heart disease as the predominant subtype.
Dissection of cellular disruptions in autism spectrum disorder comorbidities
Authors: Griffin Aoife , Chen Mei , Tiwari Vijay K. 
Published: October 2023

AbstractUp to 80% of children with autism spectrum disorder have at least one other neuropsychiatric comorbidity. The causes of such disorders are highly genetic, yet many studies fail to take analysis further than risk gene discovery to see cellular and mechanistic changes occurring. Therefore, the goal of this study was to unveil novel gene expression signatures involved in important neurodevelopmental processes that, when disrupted, lead to each of the autism comorbidities of interest. We achieved this by analysing a single‐nuclei RNA sequencing dataset with prefrontal cortex samples from autism spectrum disorder plus comorbidities for differentially expressed genes. The highest number of alterations was seen in excitatory neurons, which also showed differential population and cell–cell interactions across disorders and an increase in expression of genes involved in neurodevelopmental pathways. Interestingly, the group without comorbidities displayed an increase in neuron–neuron interactions yet a decrease in population number, suggesting a major rewiring of neuronal connections. Further analysis of the topmost significant genes from this cell type in developing prefrontal cortex datasets revealed interesting expression trajectories corresponding to important time points during corticogenesis. This further identified four novel candidate genes that show a potential link to developmental pathways that may contribute to autism and its comorbidities when dysregulated. The study provides a better understanding of co‐occurring conditions at a transcriptomic and cell‐type level and thereby aid future research in providing earlier diagnosis, care and intervention.
PEASANTS, BRIGANDS, AND THE CHRONOPOLITICS OF THE NEW LEVIATHAN IN THE MEZZOGIORNO
Authors: ESPOSITO FERNANDO 
Published: October 2023

ABSTRACTThe image of a backward, archaic South whose barbarian population had remained at a low tier of civilization was a child of Italian unification. Not unlike the Orientalist East, the South that meridionalist discourse brought forth was a “chronotopos”—that is, a time‐space that had supposedly remained in the past. The war against brigandage in the Mezzogiorno demonstrates the workings of the “politics of historicism.” This article first sheds some light on the grande brigantaggio and on the descriptions of the South that it generated among both contemporaries and later historians, such as Eric Hobsbawm. With the help of Pierre Clastres's and James C. Scott's political anthropology, it then attempts to uncover the structure beneath the “denial of coevalness.” It argues that the dichotomy between the “backward” and the “modern” was based on the political distinction between friend and enemy, which, in the age of historicism, was temporalized; that is, the temporal dichotomy of the savage and the civilized can be understood as the historicist variant of those “asymmetric counterconcepts” that have always served the state and its representatives to demarcate the corpus politicum from other political entities, to justify the state, and to praise the advantages of being governed. In conclusion, the article addresses the close interweaving of state and history, progress and civilization, in the historicist worldview and argues that it was this nexus of state and history that drove the mechanics of time‐power.
A randomized controlled trial assessing denture adhesive efficacy on denture retention across 13 hours
Authors: Klukowska Malgorzata , Grender Julie , Gossweiler Ana 
Published: October 2023

AbstractPurposeTo compare the effects of two denture adhesive formulations on the bite force required to dislodge a maxillary denture in adult participants during a 13‐h test period.Materials and MethodsTwenty‐two participants with a fair‐to‐poor fitting maxillary denture opposed by natural dentition or a stable mandibular denture were enrolled in this single‐center, randomized, double‐blind, two‐treatment, 4‐period crossover study. Participants were randomly assigned a product usage sequence so that each participant used each product twice during the 4‐day test period. The test product was a denture cream adhesive formulated with an optimized calcium/zinc partial salt of polyvinyl methyl ether/maleic acid (Fixodent Ultra technology); the control product was a cream adhesive formulated with a calcium/zinc partial salt of polyvinyl methyl ether/maleic acid (Fixodent Original technology). On each study day, bite force at dislodgement was measured with a gnathodynamometer at baseline, representing the “no adhesive” score. Then, after standardized product application to the participant's existing maxillary denture by site staff, bite force measurements were retaken at 1, 3, 5, 7, 9, 11, and 13 h. The change from baseline and the 13‐h area under the bite‐force–change‐from‐baseline curve were analyzed via an analysis of variance.ResultsTwenty‐one participants completed all test periods; one additional participant completed three test periods so 22 participants were included in the analysis. There were 15 females and 7 males with a mean age of 70 years. The mean 13‐h area under the bite‐force–change‐from‐baseline curve was 8% greater (p = 0.010) for the test adhesive (114.3 lb) than for the control adhesive (105.9 lb). Both adhesives showed a statistically significant increase in bite force (p < 0.001) at each time point compared to no adhesive.ConclusionsThe optimized calcium/zinc partial salt of polyvinyl methyl ether/maleic acid test adhesive provided superior maxillary denture retention relative to that of the control adhesive across 13 h. Both adhesives increased bite force at dislodgement compared to no adhesive.
“For the planet. For home”: Generating planetary responsibility in the climate fiction of Los Angeles
Authors: Gilson Edwin 
Published: October 2023

AbstractThis article argues that three prominent recent works of Los Angeles climate fiction—Maria Amparo Escandon's L.A. Weather (2021), Alexandra Kleeman's Something New Under the Sun (2021) and Paul Beatty's The Sellout (2016)—generate a sense of planetary responsibility. Despite their regional settings, these novels possess a planetary consciousness, illuminating the local‐global connectivity of climate change and the Anthropocene. As one of the biggest greenhouse gas emitting cities in the world, L.A. drives climate injustice, with its gargantuan energy consumption having an adverse impact on populations both within and far beyond its own borders. This article explains how literature, and climate fiction particularly, can highlight this inequality at micro and macro scales, and encourage collective opposition to it. I argue that the novels of Escandon, Kleeman and Beatty conjure the impression of responsibility identified by Kristian Shaw and Sara Upstone in their overview of post‐postmodern fiction, while also exhibiting the ‘planetarity’ discussed by Amy Elias and Christian Moraru: a term to describe the global worldview of contemporary culture. In applying these concepts to the novels examined here, I ultimately contend that Los Angeles climate fiction demystifies the spatial and political dimensions of the Anthropocene, generating planetary responsibility and addressing local and global injustice.
Raloxifene increases the risk of gastroesophageal reflux disease, Barrett's esophagus, and esophageal stricture in postmenopausal women with osteoporosis
Authors: Liu Benjamin D. , Udemba Sharon C. , Saleh Sherif , Hill Hannah , Song Gengqing , Fass Ronnie 
Published: October 2023

AbstractBackground and AimsEstrogen‐based therapies may increase the risk of gastroesophageal reflux (GERD) and its complications. We aimed to determine the effect of raloxifene on the development of GERD, Barrett's esophagus, and esophageal stricture in postmenopausal women with osteoporosis.MethodsThis was a population‐based, propensity‐matched cohort study using the TriNetX platform. Patients 50 years and older with a diagnosis of “menopause” and “osteoporosis” were included in this study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for new GERD, esophageal stricture and Barrett's esophagus after raloxifene exposure. The control cohort consisted of patients who did not start any hormonal replacement therapy. We conducted a multivariable logistic regression analysis to evaluate the effect of confounding variables and also addressed common confounding medications with 1:1 propensity score‐matching. Internal validity was confirmed by comparing to negative controls (lisinopril, atorvastatin) and positive controls (metformin, ibuprofen, aspirin).ResultsFive thousand four hundred and seventy two postmenopausal women with osteoporosis were on raloxifene of which 1908 (34.86%) developed GERD, compared to 296,067 postmenopausal who were not on raloxifene of which 90,643 (30.62%) developed GERD (OR 1.2; 95% CI 1.10–1.31, p < 0.0001). This persisted after adjusting for common medications known to affect GERD. Raloxifene was identified as a risk factor for GERD in a multivariate analysis, controlling for factors including age, obesity, smoking, and alcohol use (OR 1.51, 95% Wald CI 1.47–1.53). Raloxifene was associated with esophageal stricture (OR 1.60; 95% Wald CI 1.51–1.69) and Barrett's esophagus (OR 1.50; 95% Wald CI 1.37–1.63) in multivariate analysis. These associations persisted using sensitivity analyses.ConclusionRaloxifene increases the risk of GERD, esophageal stricture and Barrett's esophagus in postmenopausal women with osteoporosis. Further studies are needed to confirm our findings.
A sensory signature of unaffected biological parents predicts the risk of autism in their offspring
Authors: Chen Chenyi , Cheng Yawei , Wu Chien‐Te , Chiang Chung‐Hsin , Wong Ching‐Ching , Huang Chih‐Mao , Martínez Róger Marcelo , Tzeng Ovid J. L. , Fan Yang‐Teng 
Published: October 2023

AimDespite the emphasis on sensory dysfunction phenotypes in the revised diagnostic criteria for autism spectrum disorder (ASD), there has been limited research, particularly in the field of neurobiology, investigating the concordance in sensory features between individuals with ASD and their genetic relatives. Therefore, our objective was to examine whether neurobehavioral sensory patterns could serve as endophenotypic markers for ASD.MethodsWe combined questionnaire‐ and lab‐based sensory evaluations with sensory fMRI measures to examine the patterns of sensory responsivity in 30 clinically diagnosed with ASD, 26 matched controls (CON), and 48 biological parents for both groups (27 parents of individuals with ASD [P‐ASD] and 21 for individuals with CON [P‐CON]).ResultsThe ASD and P‐ASD groups had higher sensory responsivity and rated sensory stimuli as more unpleasant than the CON and P‐CON groups, respectively. They also exhibited greater hemodynamic responses within the sensory cortices. Overlapping activations were observed within these sensory cortices in the ASD and P‐ASD groups. Using a machine learning approach with robust prediction models across cohorts, we demonstrated that the sensory profile of biological parents accurately predicted the likelihood of their offspring having ASD, achieving a prediction accuracy of 71.4%.ConclusionsThese findings provide support for the hereditary basis of sensory alterations in ASD and suggest a potential avenue to improve ASD diagnosis by utilizing the sensory signature of biological parents, especially in families with a high risk of ASD. This approach holds promising prospects for early detection, even before the birth of the offspring.
An optimized procedure for Luminex‐based human platelet antigen‐specific antibody screening and identification (PakLx assay) with a cost‐effective approach and improved sensitivity
Authors: Bertrand Gerald , Griffon Julien , Renac Virginie 
Published: October 2023

AbstractBackground and ObjectivesDetection of anti‐platelet antibodies is required for the diagnosis of foetal/neonatal alloimmune thrombocytopaenia. The most commonly used methods for anti‐platelet antibody detection are the monoclonal antibody‐specific immobilization of platelet antigens (MAIPA) and the Luminex bead assay (PakLx). However, for economic reasons, the use of the PakLx assay is limited.Materials and MethodsIn the present study, we evaluated the performance of an optimized protocol based on a half‐volume of PakLx reagents. We compared two alternative procedures: one with a half‐volume of all components including patient samples, and another based on a half‐volume of reagents but a standard volume of patient sample.ResultsOur results obtained with a panel of 67 samples demonstrate improved sensitivity when using a standard sample volume.ConclusionIn the event of an inconclusive result with this optimized protocol (e.g., incomplete panel of positive Luminex beads), we recommend testing the sample with an alternative protocol (e.g., MAIPA or the original PakLx protocol).