bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of NT-proBNP and sST2 in patients with heart failure with preserved and mildly reduced ejection fraction
Authors: Podzolkov V. I. , Dragomiretskaya N. A. , Tolmacheva A. V. , Shvedov I. I. , Ivannikov A. A. , Akyol I. V. 
Published: October 2023

Aim. To study the prognostic significance of cardiobiomarkers - NT-proBNP and soluble suppression of tumorigenecity (sST2) in patients with CHF with preserved (CHFpEF) and mildly reduced EF (CHFmrEF).Material and methods. Along with a clinical examination, 207 patients (111 men and 96 women), mean age - 72.6 ± 11.4 years, underwent tests for the level of NT-proBNP and sST2 in serum. All patients were divided into 3 groups: 1 - CHFpEF (n=85), 2 - CHFmrEF (n=50); 3 (comparison group)- CHFrEF (n=72). All patients signed informed consent to participate in the study. The primary endpoint was all-cause death in 12 months. Statistical processing of the results was carried out using the Statistica 12.0 and Medcalc programs.Results. The initial values ​of NT-proBNP in patients with CHFmrEF were 691.9 [248; 1915.5] pg/ml and were significantly higher than those of CHFpEF - 445.8 [214.6; 945.7] pg/ml, but significantly lower than in CHFrEF - 1131.4 [411.5;3039.5] pg/ml, p<0.05. sST2 values ​​in group 1 (23.21 [12.17;48.7] ng/ml and group 2 (27.11 [16.98;53.76] ng/ml) did not differ, but were significantly lower than in patients with CHFrEF (44.6 [21.1; 93.5] ng/ml). After a median of 12 months 51 patients reached the primary endpoint. All-causes mortality in patients with HFpEF was 11.8%, HFmrEF - 31.9% (p <0.05), and HFrEF – 36%. A retrospective analysis of the data showed that in patients independent of their initial ejection fraction, who survived for 12 months, the levels of NT-proBNP and sST2 were significantly lower than those of the deceased. In survivors and deceased patients with CHFpEF the values ​​of NT-proBNP and sST2 were 443 [154;862,8] vs 1143,2 [223,9;2021,9] pg/ml (p=0.009) and 22,8 [12,3;33,8] vs 26,8 [9,6;74,8] ng/mL (p<0.05). In survivors and deceased patients with CHFmrEF the values ​​of NT-proBNP and sST2 were 397.4 [128.9;1088.5] vs 1939.7 [441.9;2536] pg/ml (p=0.009) and 18.6 [14.9;30.27.1] vs 59.9 [53.76;84.4] ng/mL (p=0.002). There were no significant differences in NT-proBNP and sST2 values ​​in patients with cardiac and non-cardiac causes of death. sST2 parameters in deceased patients with CHFpEF (26.8 [9.6;74.8] ng/mL) and CHFmrEF (59.9 [53.76;84.4] ng/mL) also had no significant differences (p >0.05). At ROC analysis to one-year adverse events, both NT-proBNP and sST2 showed a significant predictive value in patients with EF >40% with an optimal cut-off value of 746 pg/ml (AUC 0.709; p = 0.005, sensitivity 62%, specificity 69%) and 27.1 ng/ml (AUC 0.742; p = 0.03, sensitivity 80%, specificity 75.8%) respectively.Conclusion: NT-proBNP levels >746 pg/ml and sST2 >27.1 ng/ml should be considered as predictors of poor prognosis in CHF patients with LVEF >40%.
Wellbore Surface Conditioning for Inhibition of Asphaltene Adsorption
Authors: Mohammed Isah , Al Shehri Dhafer , Mahmoud Mohamed , Sultan Abdullah , Kamal Muhammad Shahzad , Alade Olalekan Saheed , Babu Rahul Salin , Patil Shirish 
Published: October 2023

Abstract
Asphaltene adsorption on reservoir rocks, particularly those near the wellbore, has been debated for decades, but a long-term solution is still difficult. This is partially because research into the chemistry of asphaltene is still ongoing, as is the creation of solutions that depend on the structural makeup of asphaltene. Moreover, several interrelated elements have an impact on asphaltene behavior, making it challenging to design a long-lasting solution. This study makes an effort to reduce asphaltene adsorption on carbonate rock samples by applying chelating agents to the surface. To assess the viability of the suggested remedy, adsorption studies, surface energy, and density functional theory calculations were performed.
Results show that asphaltene adsorption on chelating agent-treated carbonate surfaces can be prevented or reduced. The best chelating agent concentration must be established, though. Findings also indicated that the effectiveness of the chelating agent in preventing asphaltene adsorption increased with the number of carboxylic acid groups present in its structure. Furthermore, van der Waals interactions and hydrogen bond formation govern the chelation of Ca2+ from the carbonate surface. This offers information that is only now being reported here. Further findings confirmed the viability of asphaltene adsorption mitigation using fluids containing carboxylic acids. Also, it is necessary to investigate additional fluids that have the potential to coat the surface.
Analysis of research publications of Government and Private University in Karnataka, India: A Scientometric study
Authors: Bandi Ishappa , Laxmeshwar Sameer S , T Harish H 
Published: October 2023

Abstract
This research was done to better understand the two renowned Universities in the state of Karnataka, MAHE in Manipal and VTU in Belagavi. Their research outputs for the last five years are analyzed using the Scopus bibliographical tool. The goal of this study was to determine how the COVID-19 pandemic affected research productivity. Surprisingly, the MAHE (2351) research community published more than three times as many papers as the VTU (744) research community during the pandemic period (2020–21). The MAHE research community prefers to publish in journals > 90%, however just 61% of VTU researchers do the same. This is another significant conclusion from the study. Importantly, just 5% of researchers at MAHE publish in conferences compared to around 19% of researchers at VTU. This demonstrates that MAHE gives journal publication a greater preference; as a result, the impact of this policy is evident in the data analysis.
Structural characteristics of Niaouli forests, biodiversity, and ethnobotanical importance of the valuable species
Authors: GANGLO Isis Togbédji , KOURA Kourouma , KIKI Edmond , HOUNSA Michael , KINGBO Armand , BELLO Saliou , AOUDJI Augustin K. N. , GANGLO Jean Cossi 
Published: October 2023

Abstract

In Benin, forest resources are limited and are in the grip of alarming degradation. In southern Benin, the Niaouli forests (6°40' to 6°45' North Lat. and 2°05' to 2°10' East Long.) require special attention given their state of degradation leading to loss of biodiversity. In order to contribute to the sustainable management of the forests, our investigations focused on the characterization of the structure, floristic diversity, and forms of use of the valuable species. The data was collected by systematic sampling with rectangular meshes of 100 m × 200 m in square plots of one (01) ha each. In total, seven (07) plots were installed for the determination of dendrometric and biodiversity parameters. The regeneration of the species was counted in quadrats of 100 m² installed on a diagonal of each plot. Ethnobotanical surveys were carried out within local populations, on a sample of 188 people made of heads of peasant households or their representatives, carpenters, traditional healers, and loggers in order to identify valuable species and appraise their ethnobotanical importance. Four valuable species were identified. They were Albizia zygia, Antiaris toxicaria, Ceiba pentandra, and Newbouldia laevis. The diversity parameters showed that the forests of Niaouli are characterized by a low floristic diversity in comparison with the forest ecosystems of southern Benin. The main valuable species of the Niaouli forests were experiencing a regeneration problem likely to hinder their sustainability and sustainable use. Albizia zygia, Antiaris toxicaria, and Ceiba pentandra are used more in the form of wood respectively by 85 %, 50 %, and 75 % of respondents. Newbouldia laevis is used more in the form of an infusion by 33 %, fodder by 21 %, and wood by 21 % of respondents. Respondents cited 58 diseases treated with species from the Niaouli forests. Considering the results obtained, regular reforestation and the introduction of new adapted species must be carried out to increase the biodiversity and ecosystem services of the forests.
Ptsd Symptoms Comparison Emdr and Nfb With Ipv Survivors: Ex- Post-facto Study
Authors: Shaikh Huda 
Published: October 2023

Abstract

Given the prevalence of post-traumatic stress disorder symptoms in intimate partner violence survivors, the need for personalized treatment plans for intimate partner violence (IPV) survivor post-traumatic stress disorder (PTSD) care, and no comparison of eye movement desensitization and reprocessing (EMDR) and neurofeedback therapy (NFB) in response to PTSD care, the researcher aimed to fill the gap in research. Using archival data, a comparison between EMDR therapy and NFB therapy in response to IPV survivor PTSD was analyzed. While there exists support for each modality in the existing literature, there does not exist a comparison of the two in response to IPV survivor PTSD symptoms. The theoretical lens utilized for the study were the theory of neuroscience (TN) and humanistic person-centered theory (PCT). The applied research methodology was quantitative, and the research design was ex-post-facto quasi-experimental. Findings did not support a statistically significant difference between the EMDR group and the NFB group in response to pre and post PTSD symptoms thereby failing to reject the null hypothesis for the main research question of the study. Findings pertaining to the sub-questions however noted a statically significant decrease in pre-and post-mean scores within the EMDR group and the NFB group thereby rejecting the null hypotheses for both sub-questions. The study’s findings suggest that NFB carries similar relief of PTSD symptoms as EMDR does. Several limitations pertaining to the study sample’s characteristics, external factors, and the study’s design exist. For example, given the study’s design, a control group was not present. Recommendations for future research include considering the interventions, ENDR and NFB, during the conceptualization and development of theories to test into practice while also testing the efficacy of other alternative therapeutic interventions that serve to be helpful for PTSD care. By doing so, researchers may be able to develop appropriate, effective, and restorative care for IPV survivors suffering from PTSD symptoms along with a wide variety of other mental health concerns.
Study protocol: a core outcome set for perioperative exercise clinical effectiveness trials for lung cancer patients
Authors: Zhou Wanjun , Zhang Yawen , Wang Zhiwei , Zhang Liang , Zhang Xinqiong 
Published: October 2023

Abstract
Background
Outcome assessment in perioperative exercise trials of lung cancer is heterogeneous, often omitting those that are important and patient-relevant. This hinders evidence synthesis. To solve this problem, a core outcome set, an agreed standardized set of outcomes to be measured and reported to reduce heterogeneity among outcome measures, is needed. This study protocol describes the methodology, aiming to develop a core outcome set for perioperative exercise intervention trials for lung cancer in clinical practice.
Methods
The project will follow the standard methodology recommended by the Core Outcome Measures in Effectiveness Trials (COMET) initiative, Which will be divided into four steps. Stage Ⅰ: Conduct a scoping review of outcomes reported in clinical trials and protocols to develop a list of potential outcome domains.. Stage Ⅱ: Conduct semi-structured interviews to obtain important outcomes for patients. Stage Ⅲ: Choose the most important outcomes by conducting two-round Delphi surveys. Stage Ⅳ: Establish consensus in a face-to-face meeting to discuss the final core outcome set.
Discussion
This is the first project identified for the core outcome set of outcomes for perioperative exercise trials for lung cancer, which will improve the quality, comparability, and usability of future trials and positively impact the perioperative exercise and the care of patients with lung cancer.
Trials registration
Core Outcome Measurement in effectiveness Trials (COMET) Initiative database registration:
https://www.comet-initiative.org/Studies/Details/2091
Pre-Job loss Grief Reactions and Work Attachment among Sick-Listed Employees: Introduction of the Imminent Job Loss Scale
Authors: Eersel Janske H. W. , Wickham Miriam I. , Smid Geert E. , Boelen Paul A. 
Published: October 2023

Abstract

Background: With this study, we aimed to explore the emotional experiences of sick-listed employees facing imminent job loss, as this emotional distress may hinder successful job search outcomes. The study had two objectives: (1) to develop and validate the Imminent Job Loss Scale (IJLS) for assessing pre-job loss grief reactions and (2) to examine its relationship to work attachment.
Methods: Development of the 9-item IJLS was carried out using feedback from an expert panel, consisting of five academic experts in grief and labour, five re-integration specialists, and five sick-listed employees facing imminent job loss. The psychometric properties of the IJLS were evaluated, and its association with work attachment was examined using data from 200 sick-listed employees facing imminent job loss.
Results: The IJLS demonstrated strong internal consistency and temporal stability, distinctiveness from depression and anxiety symptoms, and strong convergent validity. Work-centrality and organizational commitment were positively related to pre-job loss grief reactions, while work engagement and calling showed no significant associations.
Conclusion: This study provides valuable insights into pre-job loss grief reactions and shows the potential utility of the IJLS for screening and monitoring purposes. Understanding pre-job loss grief reactions can improve the re-integration and job prospects of sick-listed employees. In future research, explorations of these dynamics should continue to provide better support to sick-listed employees during this challenging period.
Genetic analysis of albinism caused by compound heterozygous mutation of OCA2 gene in a Chinese family
Authors: Wang Yanan , Chang Yujie , Gao Mingya , Zang Weiwei , Liu Xiaofei 
Published: October 2023

Abstract
Background Oculocutaneous albinism (OCA) is a group of rare genetic disorders characterized by a reduced or complete lack of melanin in the skin, hair, and eyes. Patients present with colorless retina, pale pink iris, and pupil, and fear of light. The skin, eyebrows, hair, and other body hair are white or yellowish-white. These conditions are caused by mutations in specific genes necessary for the production of melanin. OCA is divided into eight clinical types (OCA1-8), each with different clinical phenotypes and potential genetic factors. This study aimed to identify the genetic causes of non-syndromic oculocutaneous albinism (OCA) in a Chinese Han family.
Methods We conducted a comprehensive clinical examination of the family members, screened the mutation gene sites using the whole exon sequencing (WES) technology, and verified the sites with Sanger sequencing.
Results The clinical manifestations of the patient were white skin, yellow hair, freckles in the area of exposure, decreased vision, blue iris, the central fovea of the macula being underdeveloped, and the pigmentation of the fundus being insufficient. The WES test results indicate that the patient has a compound heterozygous mutation in the OCA2 gene (c.1258G>A (p.G420R), c.1441G>A (p.A481T), and c.2267-2A>C), respectively, originating from her parents. Among them, c.1258G>A (p.G420R) is a novel variant with extremely high pathogenicity. Our analysis suggests that the compound heterozygous mutation in the OCA2 gene may be the main cause of morbidity in this patient.
Conclusions The widespread application of next-generation sequencing technologies such as WES in clinical practice can effectively replace conventional detection methods and assist in the diagnosis of clinical diseases more quickly and accurately. The newly discovered c.1258G>A (p.G420R) mutation can update and expand the gene mutation spectrum of OCA2-type albinism.
Enhancing supply chain security with automated machine learning
Authors: Wang Haibo , Sagbansua Lutfu , Alidaee Bahram 
Published: October 2023

Abstract

Increasing scale and complexity of global supply chains have led to new challenges spanning a variety of fields such as supply chain disruptions due to long waiting lines at the ports, material shortages, and inflation. Coupled with the size of supply chains and availability of vast amounts of data, efforts towards tackling such challenges have led to an increasing interest towards the application of machine learning methods in many aspects of supply chains. Compared to other solution methods, machine learning methods particularly perform better in making predictions based on a set of observations and approximating optimal solutions faster. Machine learning methods are called for analyzing very large datasets. This paper presents an automated machine learning framework to enhance the supply chain security such as detection of fraudulent activities, prediction of maintenance needs, and material backorder prediction. Results indicate that many factors affect the performance of ML methods such as sampling method, encoding categorical values, feature selection, hyperparameter optimization for different algorithms. In general, the number of variables poses a limit for mathematical programming models to performance on large-scale problem. The automated machine learning framework streamlines the processes including data processing, models construction, hyperparameter optimization and inference deployment. This paper contributes to the body of knowledge on supply chain security by developing an automated machine learning framework to detect fraud and to predict supply chain maintenance needs and material backorder.
Research on the mechanism of supply chain default risk contagion
Authors: Huaqiao SHEN , Jinlong CHEN 
Published: October 2023

Abstract
Absrtact: under the background of macroeconomic fluctuation, this paper discusses the influence of credit default risk contagion of one agent on the second default of another agent in supply chain. The network model of credit risk contagion is established by complex network theory, with the help of mathematical modeling and empirical data, the paper discusses the mechanism of credit risk contagion, which is influenced by the inter-firm relationship, individual risk resistance and the monitoring intensity of market regulator. Furthermore, the paper analyzes the potential heterogeneity of credit default in supply chain network, and reveals the mechanism of the effect of long-term debt on credit default risk in supply chain network. This study is of great theoretical value and practical significance for further analyzing the mechanism of credit risk contagion in supply chain, promoting the sustainable and healthy development of our economy and the formulation of national policies.
Resuscitation, yes or no?The criteria for transferring patients with hematological malignancies to intensive care.A qualitative study
Authors: Bordier Violaine , Filbet Marilene , Sissoix Corinne , Tricou Colombe , Pereira Bruno , Guastella Virginie 
Published: October 2023

Abstract

Background: Having a hematological malignancy increases the risk of a poor-quality end of life and of dying in intensive care. There is no prognostic score to predict survival on admission to intensive care, but many patients die there. To identify the criteria used in deciding to transfer patients with hematological malignancies to intensive care.
Methods : It is a qualitative study. For each patient with a hematological malignancy who died in intensive care, the resuscitator and hematologist involved in the decision to transfer the patient to intensive care were contacted. The study ran at Lyon Sud Hospital Center, between 1 November 2018 and 30 April 2019. Semi-structured interviews were conducted with data triangulation. Seventeen doctors were contacted, and 17 interviews were conducted.
Results: When transferring a patient with a hematological malignancy to intensive care, we identified (i) patient-specific decision criteria for the transfer, namely prognosis of the disease and treatments received, and (ii) decision criteria specific to hematologists and resuscitators, namely difficulty confronting management failure, convenience of transfer to the ICU for hematologists, and attachment of hematologists to their patients.
Conclusion: Organizational convenience of transfer to intensive care was the main criterion for hematologists, but emotional attachment favored futile obstinacy, doing everything possible to the detriment of the patient's comfort. It would be useful to make an upstream appraisal of the impact that an early evaluation of the level of care of patients with hematological malignancies could have on reducing deaths in intensive care.
Relationship between Vitamin D Levels and Pediatric Celiac Disease: A Systematic Review and Meta-analysis
Authors: Sun Yanhong , Zhou Qing-xue , Tian Dan-dan , Zhou Jian-ming , Dong Shi-lei 
Published: October 2023

Abstract
Background: The relationship between vitamin D (VitD) levels and pediatric celiac disease (CD) remains controversial. In this study, we conducted a systematic review and meta‐analysis to examine the relationship between VitD and pediatric CD.
Methods: We screened relevant studies from PubMed, EMBASE and Web of Science published in English from January 1, 2000, to August 1, 2023. The included studies were assessed according to the STROBE checklist. Heterogeneity was quantified by Cochran’s Q test and the I2 statistic. Publication bias was estimated by Begg’s test and Egger test. Meta‐regression was used to detect potential sources of heterogeneity.
Results: A total of 26 studies were included in the meta-analysis. Average 25(OH)D levels, as the main form of VitD, there was significant difference in CD patients and healthy controls (weighted mean difference (WMD) = −5.77, 95% confidence interval (CI) = [−10.86, − 0.69] nmol/L). Meanwhile, there was significant difference in the incidence of 25(OH)D deficiency between CD patients and healthy controls (odds ratio 2.20, 95% CI= [1.19, 4.08]). Ten articles reported changes in 25(OH)D levels before and after administering a GFD in patients with CD, while the result of this study revealed no change in 25(OH)D levels in CD patients after a gluten-free diet (GFD) compared to controls (WMD = −2.22, 95% CI = [−7.25, 2.81] nmol/L).
Conclusions: VitD levels in pediatric CD patients were lower than healthy controls, and 25(OH)D deficiency was more prevalent in CD patients. We found no change in 25(OH)D levels in CD patients after GFD compared to controls, which inconsistent with previous research. Further well-designed, longitudinal, prospective cohort studies focusing on the role of VitD in the pathogenesis of CD are therefore needed.