bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adrenal ablation as a treatment for hypertension: analyzing the dielectric properties of adrenal glands for microwave ablation technologies
Authors: Amin Bilal , Cappiello Grazia , Kraśny Marcin J. , Dunne Eoghan , Lowery Aoife , Dennedy Michael Conall , Prakash Punit , Elahi Adnan , O’Halloran Martin 
Published: December 2023

AbstractAdrenal gland-induced hypertension, also known as secondary hypertension, is a medical condition caused by an underlying adrenal pathology, most typically adrenocortical adenomas. Current clinical practices involve pharmacotherapy or surgical resection to treat adrenal gland diseases that cause hypertension. However, due to the limitations of these treatment options, microwave ablation (MWA) has emerged as a promising minimally invasive alternative. An accurate understanding of the dielectric properties of adrenal glands would support the further development and optimization of MWA technology for treating adrenal tumors. Only a few studies have examined the dielectric properties of both human and animal adrenal glands, and the sample sizes of these studies have been relatively small. Therefore, further dielectric data of human and animal adrenal glands are warranted. This paper presents the ex vivo dielectric properties of the ovine adrenal glands (medulla and cortex) and summarizes the published literature on dielectric data of adrenal glands from porcine, bovine, ovine, and human samples in the microwave frequency range to analyze the consistency and reliability of the reported data. The dielectric properties of the ovine adrenal glands (N = 8) were measured using an open-ended coaxial probe measurement technique at frequencies ranging from 0.5 to 8.5 GHz. This study also investigated the temperature-dependent dielectric properties of the ovine adrenal medulla ranging from 37 to 64°C at frequencies ranging from 0.5 to 8.5 GHz. The dielectric properties of the ovine adrenal medulla measured in this study were found to be consistent with the literature. Moreover, the review suggests that variations exist in the dielectric properties of the adrenal medulla and cortex among species. The study also found that the dielectric properties of the adrenal medulla decrease with increasing temperature, similar to other tissues for which temperature-dependent dielectric data have been reported. This summary of dielectric data of adrenal glands and the temperature-dependent dielectric properties of the ovine adrenal medulla will accelerate the development of MWA technologies for hypertension treatment.
Reconfigurable MIMO antenna: previous advancements and the potential for future wireless communication
Authors: Kumari Puja , Dwari Santanu 
Published: December 2023

AbstractFuture smart reconfigurable antennas (RAs) (Haupt R-L and Lanagan M (2013) Reconfigurable antennas. IEEE Antennas and Propagation Magazine 55, 49–61) will likely be fully multipurpose and controlled by software and equipped with machine learning skills that can discern and respond to alterations in the radio frequency environment. Cognitive radio utilizations will be accomplished using a new generation of antenna technology and communication protocols. The effective use of frequencies and the use of polarization diversity and radiation pattern reconfigurability to send data over existing congested frequencies will be major advantages for such applications. The usage of antennas that can be reconfigured in multiple-input multiple-output (MIMO) channels will enhance channel capacity while simultaneously improving channel efficiency and lowering costs (Christodoulou C-G, Tawk Y, Lane S-A and Erwin S-R (2012) Reconfigurable antennas for wireless and space applications. Proceedings of the IEEE 100, 2250–2261). There are a lot of antennas used both at the transmitter and at the receiver front end in a MIMO system. The benefit of employing such arrangements is that different types of information can be conveyed at a similar time, boosting the spectral efficiency of communication in a multipath situation. The coding rate, modulation level, and transmission signaling method of a MIMO system can all be changed in response to changing channel circumstances and user needs. In a MIMO context, polarization reconfigurable/frequency-reconfigurable/radiation pattern RA increase the degree of freedom and enhancing the system’s performance. The usage of such antennas greatly enhances capacity by enabling a choice of various polarization configurations and pattern diversity. Antenna arrays that can be reconfigured are also an appealing MIMO system solution that needs to retain robust communication channels, particularly in portable gadgets where the area is limited.
Strong Physical Contrasts Across Two Mid‐Lithosphere Discontinuities Beneath the Northwestern United States: Evidence for Cratonic Mantle Metasomatism
Authors: Liu Tianze , Chin Emily J. , Shearer Peter 
Published: December 2023

AbstractMid‐lithosphere discontinuities are seismic interfaces likely located within the lithospheric mantle of stable cratons, which typically represent velocities decreasing with depth. The origins of these interfaces are poorly understood due to the difficulties in both characterizing them seismically and reconciling the observations with thermal‐chemical models of cratons. Metasomatism of the cratonic lithosphere has been reported by numerous geochemical and petrological studies worldwide, yet its seismic signature remains elusive. Here, we identify two distinct mid‐lithosphere discontinuities at ∼87 and ∼117 km depth beneath the eastern Wyoming craton and the southwestern Superior craton by analyzing seismic data recorded by two longstanding stations. Our waveform modeling shows that the shallow and deep interfaces represent isotropic velocity drops of 2%–8% and 4%–9%, respectively, depending on the contributions from changes in radial anisotropy and density. By building a thermal‐chemical model including the regional xenolith thermobarometry constraints and the experimental phase‐equilibrium data of mantle metasomatism, we show that the shallow interface probably represents the metasomatic front, below which hydrous minerals such as amphibole and phlogopite are present, whereas the deep interface may be caused by the onset of carbonated partial melting. The hydrous minerals and melts are products of mantle metasomatism, with CO2‐H2O‐rich siliceous melt as a probable metasomatic reagent. Our results suggest that mantle metasomatism is probably an important cause of mid‐lithosphere discontinuities worldwide, especially near craton boundaries, where the mantle lithosphere may be intensely metasomatized by fluids and melts released by subducting slabs.
Investigating the Impact of Irrigation on Malaria Vector Larval Habitats and Transmission Using a Hydrology‐Based Model
Authors: Jiang Ai‐Ling , Lee Ming‐Chieh , Selvaraj Prashanth , Degefa Teshome , Getachew Hallelujah , Merga Hailu , Yewhalaw Delenasaw , Yan Guiyun , Hsu Kuolin 
Published: December 2023

AbstractA combination of accelerated population growth and severe droughts has created pressure on food security and driven the development of irrigation schemes across sub‐Saharan Africa. Irrigation has been associated with increased malaria risk, but risk prediction remains difficult due to the heterogeneity of irrigation and the environment. While investigating transmission dynamics is helpful, malaria models cannot be applied directly in irrigated regions as they typically rely only on rainfall as a source of water to quantify larval habitats. By coupling a hydrologic model with an agent‐based malaria model for a sugarcane plantation site in Arjo, Ethiopia, we demonstrated how incorporating hydrologic processes to estimate larval habitats can affect malaria transmission. Using the coupled model, we then examined the impact of an existing irrigation scheme on malaria transmission dynamics. The inclusion of hydrologic processes increased the variability of larval habitat area by around two‐fold and resulted in reduction in malaria transmission by 60%. In addition, irrigation increased all habitat types in the dry season by up to 7.4 times. It converted temporary and semi‐permanent habitats to permanent habitats during the rainy season, which grew by about 24%. Consequently, malaria transmission was sustained all‐year round and intensified during the main transmission season, with the peak shifted forward by around 1 month. Lastly, we evaluated the spatiotemporal distribution of adult vectors under the effect of irrigation by resolving habitat heterogeneity. These findings could help larval source management by identifying transmission hotspots and prioritizing resources for malaria elimination planning.
Precipitation Efficiencies in a Climatology of Southern Ocean Extratropical Cyclones
Authors: Dacre H. F. , Martinez‐Alvarado O. , Hodges K. I. 
Published: December 2023

AbstractPrecipitation efficiency refers to the amount of water that is lost from the atmosphere through precipitation compared to the available water vapor in the atmosphere. This metric plays a critical role in understanding precipitation patterns. However, calculating precipitation efficiency for extratropical cyclones can be challenging because cyclones are dynamic and move through the atmosphere as they evolve. To overcome this challenge, our study uses ERA5 reanalysis data to estimate precipitation efficiencies for 400 Southern Ocean cyclones, with a frame of reference that moves with the individual cyclones. Our findings indicate that at maximum intensity, average precipitation efficiencies reach a maximum of 60%/6 hr near the warm front where ascent rates are the largest. Typically, within 24–36 hr after cyclogenesis, all of the initial water vapor available within 500 km of a cyclone center is lost due to precipitation. However, a cyclone's precipitating phase is prolonged due to local evaporation and moisture flux convergence (MFC), which replenish the moisture lost via precipitation. Close to the cyclone center, MFC provides additional moisture from the environment into which cyclones are traveling. On average, this extends a cyclone's precipitation phase to over 60 hr after cyclogenesis. Thus, while moisture from the genesis location is quickly removed from the cyclone via precipitation, cyclones are replenished by moisture along their track, which doubles the timescale for a cyclone's precipitating phase.
Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography
Authors: Komatsu Hiroshi , Onoguchi Goh , Silverstein Steven M. , Jerotic Stefan , Sakuma Atsushi , Kanahara Nobuhisa , Kakuto Yoshihisa , Ono Takashi , Yabana Takeshi , Nakazawa Toru , Tomita Hiroaki 
Published: December 2023

Abstract
Introduction
Abnormal findings on optical coherence tomography (OCT) and electroretinography (ERG) have been reported in participants with schizophrenia spectrum disorders (SSDs). This study aims to reveal the pooled standard mean difference (SMD) in retinal parameters on OCT and ERG among participants with SSDs and healthy controls and their association with demographic characteristics, clinical symptoms, smoking, diabetes mellitus, and hypertension.

Methods
Using PubMed, Scopus, Web of Science, and PSYNDEX, we searched the literature from inception to March 31, 2023, using specific search terms. This study was registered with PROSPERO (CRD4202235795) and conducted according to PRISMA 2020.

Results
We included 65 studies in the systematic review and 44 in the meta-analysis. Participants with SSDs showed thinning of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer- inner plexiform cell layer, and retinal thickness in all other segments of the macula. A meta-analysis of studies that excluded SSD participants with diabetes and hypertension showed no change in results, except for pRNFL inferior and nasal thickness. Furthermore, a significant difference was found in the pooled SMD of pRNFL temporal thickness between the left and right eyes. Meta-regression analysis revealed an association between retinal thinning and duration of illness, positive and negative symptoms. In OCT angiography, no differences were found in the foveal avascular zone and superficial layer foveal vessel density between SSD participants and controls. In flash ERG, the meta-analysis showed reduced amplitude of both a- and b-waves under photopic and scotopic conditions in SSD participants. Furthermore, the latency of photopic a-wave was significantly shorter in SSD participants in comparison with HCs.

Discussion
Considering the prior report of retinal thinning in unaffected first-degree relatives and the results of the meta-analysis, the findings suggest that retinal changes in SSDs have both trait and state aspects. Future longitudinal multimodal retinal imaging studies are needed to clarify the pathophysiological mechanisms of these changes and to clarify their utility in individual patient monitoring efforts.
Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies: an iSTOPMM study
Authors: Pérez-Escurza Oihane , Flores-Montero Juan , Óskarsson Jón Þórir , Sanoja-Flores Luzalba , del Pozo Julio , Lecrevisse Quentin , Martín Silvia , Reed Elín Ruth , Hákonardóttir Guðlaug Katrín , Harding Stephen , Þorsteinsdóttir Sigrún , Rögnvaldsson Sæmundur , Love Thorvardur Jon , Durie Brian , Kristinsson Sigurður Yngvi , Orfao Alberto 
Published: December 2023

AbstractMonoclonal gammopathy of undetermined significance (MGUS) is the earliest discernible stage of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). Early diagnosis of MG may be compromised by the low-level infiltration, undetectable to low-sensitive methodologies. Here, we investigated the prevalence and immunophenotypic profile of clonal (c) plasma cells (PC) and/or cB-lymphocytes in bone marrow (BM) and blood of subjects with a serum M-component from the iSTOPMM program, using high-sensitive next-generation flow cytometry (NGF), and its utility in the diagnostic classification of early-stage MG. We studied 164 paired BM and blood samples from 82 subjects, focusing the analysis on: 55 MGUS, 12 smoldering MM (SMM) and 8 smoldering WM (SWM). cPC were detected in 84% of the BM samples and cB-lymphocytes in 45%, coexisting in 39% of cases. In 29% of patients, the phenotypic features of cPC and/or cB-lymphocytes allowed a more accurate disease classification, including: 19/55 (35%) MGUS, 1/12 (8%) SMM and 2/8 (25%) SWM. Blood samples were informative in 49% of the BM-positive cases. We demonstrated the utility of NGF for a more accurate diagnostic classification of early-stage MG.
Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma
Authors: Huang Ziqi , Guo Yan , Li Baihui , Shen Meng , Yi Yeran , Li Li , Zhao Xiaohe , Yang Lili 
Published: December 2023

AbstractSialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which is mainly expressed on macrophages and tumor cells. However, whether Siglec-15-induced immunosuppression and poor prognosis are independent of PD-L1 remains unclear. In this study, we collected samples of 135 non-small cell lung cancers and found that Siglec-15 and PD-L1 expression were independent in non-small cell lung cancer by multiple immunofluorescence staining. Siglec-15 on macrophages (Mφ-Siglec-15) was significantly associated with DFS (p < 0.05) in PD-L1− patients with non-metastasis lung adenocarcinoma, not in PD-L1+ or lung squamous cell carcinoma patients. Moreover, stromal Siglec-15+ macrophages of Mφ-Siglec-15+PD-L1− patients were significantly more than those of Mφ-Siglec-15−PD-L1− patients (p = 0.002). We further found that Siglec-15+ macrophages polarized toward M2 and produced more IL-10, negatively associated with inflamed immunophenotype in PD-L1− patients and may inhibit CD8+T cells infiltration. In conclusion, PD-L1-independent Siglec-15+ macrophages contribute to the formation of an immunosuppressive microenvironment in non-metastasis lung adenocarcinoma patients, which may cause a higher risk of recurrence. Siglec-15 could be a potential target for normalizing cancer immunotherapy, benefiting patients who fail to respond to anti-PD-L1 therapy.
Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota
Authors: Zhao Tong , Zhang Yue , Nan Linhua , Zhu Qing , Wang Shukai , Xie Yutao , Dong Xinling , Cao Cui , Lin Xiaoliang , Lu Yu , Liu Yuxia , Huang Linjuan , Gong Guiping , Wang Zhongfu 
Published: December 2023

AbstractUnderstanding how dietary polysaccharides affect mucin O-glycosylation and gut microbiota could provide various nutrition-based treatments. Here, the O-glycan profile of the colonic mucosa and gut microbiome were investigated in C57BL/6J mice fed six structurally diverse dietary polysaccharides and a mixture of six fibers. Dietary polysaccharides increased total O-glycans, mainly by stimulating neutral glycans. Highly branched arabinogalactan promoted terminally fucosylated core 1 O-glycans; whereas linear polysaccharides, including pectin, konjac glucomannan, inulin, and the fiber mixture, favored terminally di-fucosylated O-glycans. The last three polysaccharides also lowered the level of sulfated O-glycans and sialylated mono-fucosylated O-glycans. Varied monosaccharide composition in mixed polysaccharides had a synergistic beneficial effect, boosting fucosylated neutral glycans, decreasing acidic glycans, and stimulating microbial richness and diversity. Dietary polysaccharides containing arabinose and sulfate groups enhanced the relative abundances of Akkermansia and Muribaculaceae, respectively. The present comparison reveals the relationship between dietary polysaccharide structure, mucin O-glycan composition, and intestinal microorganisms.
Age-associated alterations in thalamocortical structural connectivity in youths with a psychosis-spectrum disorder
Authors: Lewis Lydia , Corcoran Mary , Cho Kang Ik K. , Kwak YooBin , Hayes Rebecca A , Larsen Bart , Jalbrzikowski Maria 
Published: December 2023

AbstractPsychotic symptoms typically emerge in adolescence. Age-associated thalamocortical connectivity differences in psychosis remain unclear. We analyzed diffusion-weighted imaging data from 1254 participants 8–23 years old (typically developing (TD):N = 626, psychosis-spectrum (PS):N = 329, other psychopathology (OP):N = 299) from the Philadelphia Neurodevelopmental Cohort. We modeled thalamocortical tracts using deterministic fiber tractography, extracted Q-Space Diffeomorphic Reconstruction (QSDR) and diffusion tensor imaging (DTI) measures, and then used generalized additive models to determine group and age-associated thalamocortical connectivity differences. Compared to other groups, PS exhibited thalamocortical reductions in QSDR global fractional anisotropy (GFA,p-values range = 3.0 × 10–6–0.05) and DTI fractional anisotropy (FA,p-values range = 4.2 × 10–4–0.03). Compared to TD, PS exhibited shallower thalamus-prefrontal age-associated increases in GFA and FA during mid-childhood, but steeper age-associated increases during adolescence. TD and OP exhibited decreases in thalamus-frontal mean and radial diffusivities during adolescence; PS did not. Altered developmental trajectories of thalamocortical connectivity may contribute to the disruptions observed in adults with psychosis.
Macroscopic resting-state brain dynamics are best described by linear models
Authors: Nozari Erfan , Bertolero Maxwell A. , Stiso Jennifer , Caciagli Lorenzo , Cornblath Eli J. , He Xiaosong , Mahadevan Arun S. , Pappas George J. , Bassett Dani S. 
Published: December 2023

AbstractIt is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear behaviours. Here we challenge this assumption by leveraging mathematical models derived from measurements of local field potentials via intracranial electroencephalography and of whole-brain blood-oxygen-level-dependent brain activity via functional magnetic resonance imaging. We used state-of-the-art linear and nonlinear families of models to describe spontaneous resting-state activity of 700 participants in the Human Connectome Project and 122 participants in the Restoring Active Memory project. We found that linear autoregressive models provide the best fit across both data types and three performance metrics: predictive power, computational complexity and the extent of the residual dynamics unexplained by the model. To explain this observation, we show that microscopic nonlinear dynamics can be counteracted or masked by four factors associated with macroscopic dynamics: averaging over space and over time, which are inherent to aggregated macroscopic brain activity, and observation noise and limited data samples, which stem from technological limitations. We therefore argue that easier-to-interpret linear models can faithfully describe macroscopic brain dynamics during resting-state conditions.
Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression
Authors: Tobias Gabriel C. , Gomes João L. P. , Fernandes Larissa G. , Voltarelli Vanessa A. , de Almeida Ney R. , Jannig Paulo R. , de Souza Rodrigo W. Alves , Negrão Carlos E. , Oliveira Edilamar M. , Chammas Roger , Alves Christiano R. R. , Brum Patricia C. 
Published: December 2023

AbstractExercise training reduces the incidence of several cancers, but the mechanisms underlying these effects are not fully understood. Exercise training can affect the spleen function, which controls the hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC, and CT26 tumor-bearing mice displayed enlarged spleen (splenomegaly), and exercise training reduced spleen mass toward control levels in two of these models (LLC and CT26). Exercise training also slowed tumor growth in melanoma B16F10, colon tumor 26 (CT26), and Lewis lung carcinoma (LLC) tumor-bearing mice, with minor effects in mammary carcinoma 4T1, MDA-MB-231, and MMTV-PyMT mice. In silico analyses using transcriptome profiles derived from these models revealed that platelet factor 4 (Pf4) is one of the main upregulated genes associated with splenomegaly during cancer progression. To understand whether exercise training would modulate the expression of these genes in the tumor and spleen, we investigated particularly the CT26 model, which displayed splenomegaly and had a clear response to the exercise training effects. RT-qPCR analysis confirmed that trained CT26 tumor-bearing mice had decreased Pf4 mRNA levels in both the tumor and spleen when compared to untrained CT26 tumor-bearing mice. Furthermore, exercise training specifically decreased Pf4 mRNA levels in the CT26 tumor cells. Aspirin treatment did not change tumor growth, splenomegaly, and tumor Pf4 mRNA levels, confirming that exercise decreased non-platelet Pf4 mRNA levels. Finally, tumor Pf4 mRNA levels are deregulated in The Cancer Genome Atlas Program (TCGA) samples and predict survival in multiple cancer types. This highlights the potential therapeutic value of exercise as a complementary approach to cancer treatment and underscores the importance of understanding the exercise-induced transcriptional changes in the spleen for the development of novel cancer therapies.