bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Resolution Additive Manufacturing of a Biodegradable Elastomer with A Low‐Cost LCD 3D Printer
Authors: Karamzadeh Vahid , Shen Molly L. , Ravanbakhsh Hossein , Sohrabi‐Kashani Ahmad , Okhovatian Sargol , Savoji Houman , Radisic Milica , Juncker David 
Published: November 2023

AbstractArtificial organs and organs‐on‐a‐chip (OoC) are of great clinical and scientific interest and have recently been made by additive manufacturing, but depend on, and benefit from, biocompatible, biodegradable, and soft materials. Poly(octamethylene maleate (anhydride) citrate (POMaC) meets these criteria and has gained popularity, and as in principle, it can be photocured and is amenable to vat‐photopolymerization (VP) 3D printing, but only low‐resolution structures have been produced so far. Here, a VP‐POMaC ink is introduced and 3D printing of 80 µm positive features and complex 3D structures is demonstrated using low‐cost (≈US$300) liquid‐crystal display (LCD) printers. The ink includes POMaC, a diluent and porogen additive to reduce viscosity within the range of VP, and a crosslinker to speed up reaction kinetics. The mechanical properties of the cured ink are tuned to match the elastic moduli of different tissues simply by varying the porogen concentration. The biocompatibility is assessed by cell culture which yielded 80% viability and the potential for tissue engineering illustrated with a 3D‐printed gyroid seeded with cells. VP‐POMaC and low‐cost LCD printers make the additive manufacturing of high resolution, elastomeric, and biodegradable constructs widely accessible, paving the way for a myriad of applications in tissue engineering and 3D cell culture as demonstrated here, and possibly in OoC, implants, wearables, and soft robotics.
Multifunctional Separator Enables High‐Performance Sodium Metal Batteries in Carbonate‐Based Electrolytes
Authors: Liu Haoxuan , Zheng Xiaoyang , Du Yumeng , Borrás Marcela Chaki , Wu Kuan , Konstantinov Konstantin , Pang Wei Kong , Chou Shulei , Liu Huakun , Dou Shixue , Wu Chao 
Published: November 2023

AbstractSodium metal has become one of the most promising anodes for next‐generation cheap and high‐energy‐density metal batteries; however, challenges caused by the uncontrollable sodium dendrite growth and fragile solid electrolyte interphase (SEI) restrict their large‐scale practical applications in low‐cost and wide‐voltage‐window carbonate electrolytes. Herein, a novel multifunctional separator with lightweight and high thinness is proposed, assembled by the cobalt‐based metal–organic framework nanowires (Co‐NWS), to replace the widely applied thick and heavy glass fiber separator. Benefitting from its abundant sodiophilic functional groups and densely stacked nanowires, Co‐NWS not only exhibits outstanding electrolyte wettability and effectively induces uniform Na+ ion flux as a strong ion redistributor but also favors constructing the robust N,F‐rich SEI layer. Satisfactorily, with 10 µL carbonate electrolyte, a Na|Co‐NWS|Cu half‐cell delivers stable cycling (over 260 cycles) with a high average Coulombic efficiency of 98%, and the symmetric cell shows a long cycle life of more than 500 h. Remarkably, the full cell shows a long‐term life span (over 1500 cycles with 92% capacity retention) at high current density in the carbonate electrolyte. This work opens up a strategy for developing dendrite‐free, low‐cost, and long‐life‐span sodium metal batteries in carbonate‐based electrolytes.
A Piezo‐Tribovoltaic Nanogenerator with Ultrahigh Output Power Density and Dynamic Sensory Functions
Authors: Qin Siyao , Chen Jiaqi , Yang Peng , Liu Zhaoqi , Tao Xinglin , Dong Xuanyi , Hu Jun , Chu Xiangcheng , Wang Zhong Lin , Chen Xiangyu 
Published: November 2023

AbstractTribovoltaic nanogenerator (TVNG) mainly collects energy from sliding motions of two semiconducting materials, but it cannot effectively react to the pressure change in the vertical direction. Here, a piezo‐tribovoltaic nanogenerator (P‐TVNG) is proposed by integrating piezoelectric and tribovoltaic effects to collect energy from both the sliding motion and the variation of applied pressure. Hence, this P‐TVNG can gain extra performance improvement on the top of the original output limit of TVNG. The maximum output power density of P‐TVNG is up to 3.61 W m−2, which is 28.9 % higher than the highest record of the TVNG using similar materials. Additionally, the piezo‐module can work as a separated sensory component by switching the circuit, which can monitor and analyze various working parameters of TVNG. A series of dynamic characteristics of TVNG during its operation have been identified, including the hysteresis between output current and applied pressure, the influence and incompatibility of interface stress to output performance, and so on. As a multifunction of devices, this P‐TVNG system is possible to be applied in semiconductor industry, smart manufacturing, and many other fields. This work improves the performance of the TVNGs while extending its functionality, which broadens the application field of TVNG devices.
Cooperative Effect of Redox Mediator and Ion Selective Membrane to Inhibit the Shuttle Effect for Li–O2 Battery with Large Cyclic Capacity
Authors: Zhou Danzheng , Zhang Jian , Bian Tengfei , Tao Yuanfang , Liu Xiao , Han Qing , Liu Zewen , Chen Silei , Wang Jin , Zhang Peng , Zhao Yong 
Published: November 2023

AbstractAprotic lithium‐oxygen (Li–O2) batteries hardly cycle at the condition of high area capacity for realizing their high energy density, because the unconducive lithium peroxide (Li2O2) discharge product limits the electron transfer between electrode and O2/Li2O2. Here, it is demonstrated that one of redox mediator (RM), triethylene glycol bis‐2,2,6,6‐tetramethylpiperidin‐1‐oxyl radical (D‐TEMPO), can be effectively used to promote the electron transfer between electrode and Li2O2, which the shuttle effect of RM can be cooperatively inhibited by regulating the size of RM and the thickness of ion‐selective membrane. As a result, the Li–O2 battery coupled with double cathodes, D‐TEMPO, and ion‐selective membrane can be stably operated for 46 days at a capacity of 5 mAh cm−2. The concept in this work provides the cooperative design of a stable solution‐mediated pathway for high‐capacity Li–O2 battery with long cycle stability.
Visible‐Light‐Induced Denitroalkylation of β‐Nitrostyrenes with Alkyl Boronic Acids
Authors: Xu Mingli , Zhao Chenyue , Huang Yongxiang , Hu Shuo , Cheng Dongping , Xu Xiaoliang 
Published: November 2023

AbstractWithout an additional activator, the visible‐light‐catalyzed denitroalkylation of β‐nitrostyrenes and alkyl boronic acids is reported. The efficient coupling of cyclic and secondary alkyl boronic acids with various aryl nitroolefins is realized, which gives aryl alkyl olefins in 47–87 % yields. A possible mechanism involving the fact that nitrite is released from β‐nitrostyrene upon irradiation and further activates alkyl boronic acids to generate alkyl radicals is proposed based on control experiments and a literature survey.
Makromolekulare Hydrazon Hauptkettenphotoschalter
Authors: Duy Thai Linh , Fanelli Julian , Munaweera Rangika , O'Mara Megan L. , Barner‐Kowollik Christopher , Mutlu Hatice 
Published: November 2023

AbstractHydrazone – bestehend aus einer dynamischen Iminbindung und einem sauren NH‐Proton – haben sich in letzter Zeit aufgrund ihrer Fähigkeit zur Bildung thermisch bistabiler (Z) bzw. (E) Isomere als vielseitige Potoschalter erwiesen. In diesem Artikel stellen wir zwei lichtsensitive Homopolymere vor, die strukturell unterschiedliche Hydrazone als sich wiederholende Einheiten in der Hauptkette enthalten und durch „Kopf‐Schwanz“‐Polymerisation mittels azyklischer Dien‐METathese (ADMET) synthetisiert wurden. Der Hauptunterschied der beiden Polymere liegt dabei im Design des Hydrazon‐Photoschalters, insbesondere in der Lage des aliphatischen Arms, der den Rotor mit dem aliphatischen Polymerrückgrat verbindet. Es zeigt sich, dass sich das hydrodynamische Volumen der Polymere in verdünnter Lösung während der Photoisomerisierung (λ=410 nm) in entgegengesetzter Weise ändert. Darüber hinaus zeigt sich nach der Photoisomerisierung eine Veränderung der Glasübergangs‐temperatur (Tg) um fast 10 °C bei beiden Polymeren, unabhängig vom Design des jeweiligen Hydrazon‐Monomers. Die hier vorgestellte Designstrategie erlaubt es, makromolekulare Eigenschaften durch Strukturänderungen photochemisch zu kontrollieren.
Effects of Size and Asymmetry on Catalase‐Powered Silica Micro/nanomotors
Authors: Sun Jun , Wu Jie , Ju Huangxian 
Published: November 2023

AbstractEnzyme‐powered micro/nanomotors that can autonomously move in biological environment are attractive in the fields of biology and biomedicine. The fabrication of enzyme‐powered micro/nanomotors normally focuses on constructing Janus structures of micro/nanomaterials, based on the intuition that the Janus coating of enzymes can generate driving force from asymmetric catalytic reactions. Here, in the fabrication of catalase‐powered silica micro/nanomotors (C‐MNMs), an archetypical model of enzyme‐powered micro/nanomotors, we find the silica size rather than asymmetric coating of catalase determines the motion ability of C‐MNMs. The effects of size and asymmetry have been investigated by a series of C‐MNMs at various sizes (0.5, 2, 5 and 10 μm) and asymmetric levels (full‐, half‐ and most‐coated with catalase). The motion performance indicates that 500 nm and 2 μm C‐MNMs show obvious increases (varying from 134% to 618%) of diffusion coefficient, but C‐MNMs bigger than 5 μm have no self‐propulsion behaviour at all, regardless of asymmetric levels. In addition, although asymmetry facilitates enhanced diffusion of C‐MNMs, only 2 μm C‐MNMs are sensitive to asymmetric level. This work elucidates the primary and secondary roles of size and asymmetry in the preparation of C‐MNMs, paving the way to fabricate enzyme‐powered micro/nanomotors with high motion performance in future.
Reductive amination cascades in cell‐free and resting whole cell formats for valorization of lignin deconstruction products
Authors: Nain Priyanka , Dickey Roman M. , Somasundaram Vishal , Sulzbach Morgan , Kunjapur Aditya M. 
Published: November 2023

AbstractThe selective introduction of amine groups within deconstruction products of lignin could provide an avenue for valorizing waste biomass while achieving a green synthesis of industrially relevant building blocks from sustainable sources. Here, we built and characterized enzyme cascades that create aldehydes and subsequently primary amines from diverse lignin‐derived carboxylic acids using a carboxylic acid reductase (CAR) and an ω‐transaminase (TA). Unlike previous studies that have paired CAR and TA enzymes, here we examine multiple homologs of each of these enzymes and a broader set of candidate substrates. In addition, we compare the performance of these systems in cell‐free and resting whole‐cell biocatalysis formats using the conversion of vanillate to vanillyl amine as model chemistry. We also demonstrate that resting whole cells can be recycled for multiple batch reactions. We used the knowledge gained from this study to produce several amines from carboxylic acid precursors using one‐pot biocatalytic reactions, several of which we report for the first time. These results expand our knowledge of these industrially relevant enzyme families to new substrates and contexts for environmentally friendly and potentially low‐cost synthesis of diverse aryl aldehydes and amines.
A multi‐dimensional assessment of financial hardship of cancer patients using existing health system data
Authors: You Wen , Pilehvari Asal , Shi Ruoding , Cohn Wendy , Sheffield Christina , Chow Philip I‐Fon , Krukowski Becca Anne , Anderson Roger 
Published: November 2023

AbstractBackgroundExisting financial hardship screening does not capture the multifaceted and dynamic nature of the problem. The use of existing health system data is a promising way to enable scalable and sustainable financial hardship screening.MethodsWe used existing data from 303 adult patients with cancer at the University of Virginia Comprehensive Cancer Center (2016–2018). All received distress screening and had a valid financial assistance screening based solely on household size‐adjusted income. We constructed a composite index that integrates multiple existing health system data (Epic, distress screening, and cancer registry) to assess comprehensive financial hardship (e.g., material conditions, psychological responses, and coping behaviors). We examined differences of at‐risk patients identified by our composite index and by existing single‐dimension criterion. Dynamics of financial hardship over time, by age, and cancer type, were examined by fractional probit models.ResultsAt‐risk patients identified by the composite index were generally younger, better educated, and had a higher annual household income, though they had lower health insurance coverage. Identified periods to intervene for most patients are before formal diagnosis, 2 years, and 6 years after diagnosis. Within 2 years of diagnosis and more than 4 years after diagnosis appear critical for subgroups of patients who may suffer from financial hardship disparities.ConclusionExisting health system data provides opportunities to systematically measure and track financial hardship in a systematic, scalable and sustainable way. We find that the dimensions of financial hardship can exhibit different patterns over time and across patient subgroups, which can guide targeted interventions. The scalability of the algorithm is limited by existing data availability.
Involvement of the OTUB1‐YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma
Authors: Jin Shengjian , Tsunematsu Takaaki , Horiguchi Taigo , Mouri Yasuhiro , Shao Wenhua , Miyoshi Keiko , Hagita Hiroko , Sarubo Motoharu , Fujiwara Natsumi , Qi Guangying , Ishimaru Naozumi , Kudo Yasusei 
Published: November 2023

AbstractBackgroundComprehending the molecular mechanisms underlying head and neck squamous cell carcinoma (HNSCC) is vital for the development of effective treatment strategies. Deubiquitinating enzymes (DUBs), which regulate ubiquitin‐dependent pathways, are potential targets for cancer therapy because of their structural advantages. Here we aimed to identify a potential target for HNSCC treatment among DUBs.MethodsA screening process was conducted using RNA sequencing data and clinical information from HNSCC patients in the TCGA database. A panel of 88 DUBs was analyzed to identify those associated with poor prognosis. Subsequently, HNSCC cells were modified to overexpress specific DUBs, and their effects on cell proliferation and invasion were evaluated. In vivo experiments were performed to validate the findings.ResultsIn HNSCC patients, USP10, USP14, OTUB1, and STAMBP among the screened DUBs were associated with a poor prognosis. Among them, OTUB1 showed the most aggressive characteristics in both in vitro and in vivo experiments. Additionally, OTUB1 regulated the stability and nuclear localization of YAP1, a substrate involved in cell proliferation and invasion. Notably, OTUB1 expression exhibited a positive correlation with the HNSCC‐YAP score in HNSCC cells.ConclusionsThis study highlights the critical role of OTUB1 in HNSCC progression via modulating YAP1. Targeting the OTUB1‐YAP1 axis holds promise as a potential therapeutic strategy for HNSCC treatment.
Effectiveness of SARS‐CoV‐2 testing strategies: A scoping review
Authors: Saif‐Ur‐Rahman KM , Movsisyan Ani , Kothari Kavita , Conway Thomas , Tierney Marie , Madden Caoimhe , Taneri Petek Eylul , O'Halloran Jane A. , Nurdin Nadra , Murphy Lena , Mulholland Deirdre , Tricco Andrea C. , Devane Declan 
Published: November 2023

AbstractIntroductionRapid identification of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infections by testing potentially reduced coronavirus disease‐19 (COVID‐19) cases. Testing strategies varied across countries and during different stages of the pandemic. This scoping review aims to map the available evidence on the effectiveness of SARS‐CoV‐2 testing strategies for suspected cases and asymptomatic populations to inform the development of World Health Organization recommendations for SARS‐CoV‐2 testing strategies.MethodsWe followed the standard methods for scoping reviews. We searched Medline (OVID), EMBASE (Elsevier), and Europe PMC using a comprehensive search strategy. The search was conducted in January 2023 and covered the period from January 2020 to January 2023. Two review authors independently screened the titles and abstracts, and full texts. Data were extracted onto a pilot‐tested form by a review author and cross‐checked by another review author. We provided a descriptive report summarizing the extracted data around the outcomes and created an interactive map of the available evidence using the evidence for policy and practice mapper.ResultsWe identified 34,550 citations from the databases. After the screening, we included 17 studies from 11 countries for data extraction. The study designs were randomized controlled trials (n = 3), nonrandomized experimental studies (n = 3), cohort studies (n = 3), cross‐sectional studies (n = 4), self‐controlled case series (n = 1), and economic evaluations (n = 3). Among the included studies, 14 used reverse transcription‐polymerase chain reaction and 10 studies used antigen‐detecting rapid diagnostic test. The settings of the studies were healthcare facilities (n = 8), communities (n = 4), schools, and workplaces (n = 3). Included studies considered symptomatic and asymptomatic individuals, or both, or asymptomatic contacts. Most of the studies (n = 14) reported the COVID‐19 positivity rate as the primary outcome. Other reported outcomes are the number of COVID‐19 cases (n = 11), number of hospitalizations and deaths (n = 3), and cost (n = 3).ConclusionWe identified evidence gaps in the effectiveness of SARS‐CoV‐2 testing strategies, particularly in specific settings such as schools and long‐term care facilities. This scoping review provides a foundation for further research, allowing researchers and stakeholders to focus on addressing the identified gaps.
Low‐burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation
Authors: László Tamás , Kotmayer Lili , Fésüs Viktória , Hegyi Lajos , Gróf Stefánia , Nagy Ákos , Kajtár Béla , Balogh Alexandra , Weisinger Júlia , Masszi Tamás , Nagy Zsolt , Farkas Péter , Demeter Judit , Istenes Ildikó , Szász Róbert , Gergely Lajos , Sulák Adrienn , Borbényi Zita , Lévai Dóra , Schneider Tamás , Pettendi Piroska , Bodai Emese , Szerafin László , Rejtő László , Bátai Árpád , Dömötör Mária Á , Sánta Hermina , Plander Márk , Szendrei Tamás , Hamed Aryan , Lázár Zsolt , Pauker Zsolt , Radványi Gáspár , Kiss Adrienn , Körösmezey Gábor , Jakucs János , Dombi Péter J , Simon Zsófia , Klucsik Zsolt , Gurzó Mihály , Tiboly Márta , Vidra Tímea , Ilonczai Péter , Bors András , Andrikovics Hajnalka , Egyed Miklós , Székely Tamás , Masszi András , Alpár Donát , Matolcsy András , Bödör Csaba 
Published: November 2023

AbstractTP53 aberrations predict chemoresistance and represent a contraindication for the use of standard chemoimmunotherapy in chronic lymphocytic leukaemia (CLL). Recent next‐generation sequencing (NGS)‐based studies have identified frequent low‐burden TP53 mutations with variant allele frequencies below 10%, but the clinical impact of these low‐burden TP53 mutations is still a matter of debate. In this study, we aimed to scrutinise the subclonal architecture and clinical impact of TP53 mutations using a sensitive, NGS‐based mutation analysis in a ‘real‐world’ cohort of 901 patients with CLL. In total, 225 TP53 mutations were identified in 17.5% (158/901) of the patients; 48% of these alterations represented high‐burden mutations, while 52% were low‐burden TP53 mutations. Low‐burden mutations as sole alterations were identified in 39% (62/158) of all mutated cases with 82% (51/62) of these being represented by a single low‐burden TP53 mutation. Patients harbouring low‐burden TP53 mutations had significantly lower time to first treatment compared to patients with wild‐type TP53. Our study has expanded the knowledge on the frequency, clonal architecture, and clinical impact of low‐burden TP53 mutations. By demonstrating that patients with sole low‐burden TP53 variants represent more than one‐third of patients with TP53 mutations and have an increased risk for treatment initiation, our findings strengthen the need to redefine the threshold of TP53 variant reporting to below 10% in the routine diagnostic setting.
A multivariable analysis delineating hair color, hair dyeing, and hat wearing as predictors of level of cocaine and MDMA detection in human hair samples
Authors: Palamar Joseph J. , Cleland Charles M. , Vincenti Marco , Salomone Alberto 
Published: November 2023

AbstractResearch suggests that hair color, hair dyeing, and perspiration can bias hair test results regarding drug exposure, but research is needed to examine such associations in a multivariable manner. In this epidemiology study, adults were surveyed entering nightclubs and dance festivals in New York City, and 328 provided hair samples, which were analyzed using ultra‐high‐performance liquid chromatography–tandem mass spectrometry to determine the level of detection of cocaine and 3,4‐methylenedioxymethamphetamine (MDMA). Reporting use was not an inclusion criterion for analysis. We used two‐part multivariable models to delineate associations of hair color, past‐year hair dyeing, and frequency of past‐month hat wearing (which may increase perspiration) in relation to any vs. no detection of cocaine and MDMA as well as level of detection, controlling for hair length, self‐reported past‐year cocaine/ecstasy/MDMA use, and age, sex, and race/ethnicity. Those reporting having dyed their hair were at increased odds of having any level of cocaine detected (adjusted odds ratio [aOR] = 3.75, 95% CI confidence interval [CI]: 1.85–6.70), and compared to those with brown hair, those with blond(e) hair on average had lower levels of cocaine (ng/mg) detected (beta = −7.97, p = 0.025). Those reporting having dyed their hair were at increased odds of having any level of MDMA detected (aOR = 3.05, 95% CI: 1.44–6.48), and compared to those who reported never wearing a hat, those who reported wearing a hat daily or almost daily on average had lower levels of MDMA (ng/mg) detected (beta = −6.61, p = 0.025). This study demonstrates the importance of using multivariable models to delineate predictors of drug detection.
Fe Nanoparticles Decorated Pinewood‐Derived Carbon for Highly Efficient Electrocatalytic Conversion of Nitrite to Ammonia
Authors: Li Tengyue , He Xun , Cai Zhengwei , Fan Xiaoya , Dong Kai , Yao Yongchao , He Lang , Zheng Dongdong , Sun Shengjun , Luo Yongsong , Chen Junhao , Jiang Zhenju , Sun Xuping 
Published: November 2023

AbstractElectrochemical nitrite (NO2−) reduction reaction (NO2−RR) presents a sustainable approach for the electrochemical synthesis of ammonia (NH3), concurrently facilitating the removal of NO2− contaminants. Developing NO2−RR electrocatalysts with high NH3 selectivity and satisfactory NH3 yield poses a significant challenge. Herein, we present Fe nanoparticles decorated pinewood‐derived carbon (Fe/PC) as a highly proficient electrocatalyst for the conversion of NO2− to NH3. The well‐designed Fe/PC electrocatalyst achieves an impressive NH3 yield of 21924.6 μg h−1 cm−2 and a high Faradic efficiency of 91.5 % under ambient conditions. Notably, the Fe/PC catalyst exhibits robust stability in both prolonged electrolysis and cyclic electrolysis assessments.