bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between serum neurofilament light chain and short-term outcomes in patients with hypertensive intracerebral hemorrhage
Authors: Zhou Jun , Zhao Yulin , Zhang Lichuang , Dong Yanrui , Li Zehu , Wang Yansong , Wang Xiangdong 
Published: February 2025

Abstract

Objective
To explore the correlation between changes in serum neurofilament light chain protein and clinical prognosis in patients with hypertensive intracerebral hemorrhage, combined with other clinical indicators. This article provides evidence for clinicians to effectively evaluate the prognosis of patients with hypertensive intracerebral hemorrhage and formulate diagnosis and treatment plans.

Methods
We selected 202 patients with hypertensive intracerebral hemorrhage admitted to different hospital from 2021 to 2022, and the clinical data of the patients were collected immediately after admission. Blood samples of the patients were collected, centrifuged, and the upper serum layer was collected and stored in the freezer at -80℃. During the same period, the sera of 30 age-matched healthy subjects were collected as the control group. The serum values of light chain protein of the experimental group and control group were measured by enzyme-linked immunosorbent assay. The Glasgow Outcome Scale of enrolled patients at 30 days of onset was recorded, and the collected data were statistically analyzed.

Results
After statistical treatment, systolic blood pressure, admission Glasgow coma scale score, hematoma volume, and serum light chain protein values on day 3 and day 7 were statistically significant between the groups with good prognosis and those with poor prognosis (all P < .001).

Conclusion
The serum light chain protein level of patients with hypertensive intracerebral hemorrhage was significantly higher than that of healthy people. The prognosis of the experimental group was correlated with the change trend of serum light chain protein.
Shared prognostic information in amyotrophic lateral sclerosis – systematic assessment of the patients’ perception of neurofilament light chain and the ALS functional rating scale
Authors: Möhwald Lukas Maximilian , Maier André , Grehl Torsten , Weyen Ute , Weydt Patrick , Günther René , Lingor Paul , Göricke Bettina , Petri Susanne , Grosskreutz Julian , Boentert Matthias , Cordts Isabell , Weishaupt Jochen H. , Dorst Johannes , Münch Christoph , Meyer Thomas , Baum Petra 
Published: February 2025

Abstract

Background
In amyotrophic lateral sclerosis (ALS), neurofilament light chain (NfL) was introduced as a prognostic biomarker. More recently, NfL values can be shared on the patient’s ALS app. Also, the ALS functional rating scale (ALSFRS-R) is an established patient-reported assessment of disease progression. The scale can be obtained during clinic visits or remotely. However, few systematic data are available on the patients’ perception of prognostic information about NfL and ALSFRS-R and the remote sharing of these data.

Methods
In a multicenter study, 149 ALS patients were assessed for their perception of shared information about NfL and ALSFRS-R using an investigator-designed survey and established questionnaires. The recommendation of NfL and ALSFRS-R to fellow patients was assessed using the Net Promoter Score (NPS). Burden by shared information was investigated in two distinct settings: (1) clinic information when receiving results on NfL and/or ALSFRS-R during clinic visits and (2) remote information about NfL values and self-rating of the ALSFRS-R via the ALS app. General anxiety was measured by the Fear of Progression Questionnaire – Short Form (FoP-Q-SF).

Results
Information about NfL and ALSFRS-R, respectively (n = 149), were regarded as relevant for patients themselves (75.2% and 77.2%) and for research (98% and 96%). The NPS showed a high recommendation rate for NfL (+ 21) and ALSFRS-R (+ 26). Only a minority of patients perceived shared information about NfL as burdensome, with a lower burden in the clinic setting (n = 1, 4.2%) than in the remote setting (n = 8, 12%; p = 0.015). Remote digital assessment of the ALSFRS-R was well received, with a reported burden in 9.8% (n = 9) of the participants. The FoP-Q-SF revealed fear of progression in 40% of the respondents (n = 60).

Conclusions
This study underscored the relevance of information about NfL and ALSFRS-R from the patient’s perspective. Furthermore, patients proved to appreciate the relevance of this data for ALS research. Sharing information about NfL or ALSFRS-R was rarely perceived as burdensome even in a remote setting using the ALS app. These findings pave the way for further development of the patient-centered approach to sharing prognostic information in ALS.
New anchovy burgers: a sustainable and nutritious alternative to red meat in fast food
Authors: Russo Giovanni Luca , Langellotti Antonio L. , Di Monaco Rossella , Buonocunto Gabriele , Colonna Francesca , Velleca Nunzio , Di Paola Anna Ilaria , Avella Lucia , Cavella Silvana , Masi Paolo 
Published: February 2025

Abstract
This study presents an innovative anchovy burger formulation optimized using response surface methodology and Ideal Profile method. The objective is to create a nutritious, appealing, and environmentally friendly alternative to traditional red meat burgers. The research utilized a two-tiered experimental approach: an initial screening using Plackett-Burman Design to evaluate the impact of various ingredients on cooking yield, texture, and moisture retention, followed by an optimization phase employing a Central Composite Design. Key findings revealed that oat fiber and potato flakes significantly enhance the burger’s cooking yield and sensory characteristics. The optimized formulation, comprising 4% oat fibers and 4% potato flakes, exhibited superior texture and consumer preference. Nutritional analysis demonstrates that the optimized anchovy burger outperforms conventional beef and popular fast food chain burgers in terms of protein content and dietary fibers, while also being a rich source of long-chain polyunsaturated fatty acids. This research contributes to the fast-food industry by offering a product that meets sensory and nutritional requirements while also promoting sustainability. The findings lay a foundation for future studies to further explore the interplay of sensory attributes and consumer preferences, potentially guiding the development of innovative and sustainable fast-food products.

Graphical Abstract
Factors determining primary or delayed surgery for unilateral, non-metastatic Wilms tumor: a multicentric Egyptian study
Authors: Elgendy Ahmed , AbouZeid Amr Abdelhamid , El-Debeiky Mohamed , Mohammad Shaimaa Abdelsattar , Romeih Marwa , Ebeed Ahmed , Abouheba Mohamed , Takrouney Mohammed Hamada , Mostafa Mahmoud , Khairi Ahmed , El-Naggar Osama , Shehata Sameh 
Published: February 2025

Abstract

Background
There is no consensus on the initial treatment modality for unilateral Wilms tumor (WT) in Egypt. This multicenter study investigates the factors guiding the decision-making between primary surgery and delayed resection for this tumor in our clinical practice. A retrospective analysis was conducted on all patients with unilateral, non-metastatic WT treated at four major Egyptian institutions from January 2019 to January 2024. Clinical characteristics, management details, and outcomes were reviewed. Timing of nephrectomy was analyzed in relation to tumor characteristics such as size, midline crossing, suspicion of perinephric spread, intravascular extension, and retroperitoneal lymphadenopathy.

Results
The study included 112 patients with a median age of 2.8 years. The median largest tumor diameter was 12 cm (range, 7–16 cm). Primary nephrectomy was performed in 62 patients (55.4%), while 50 (44.6%) underwent delayed resection after biopsy and neoadjuvant chemotherapy. Tumors larger than 12 cm and tumors crossing the midline were reported in 38.5% and 35% of all patients, respectively. Suspicion of perinephric spread was noted in 31% of patients, and significant lymphadenopathy in 13.5%. Intravascular tumor thrombus was detected in 7 patients (6.25%) at various locations. Statistically significant differences were observed between the primary surgery and delayed resection groups regarding suspicion of perinephric spread, intravascular thrombus, and retroperitoneal lymphadenopathy (p-value < 0.001, 0.002, and < 0.001, respectively). However, tumor diameter and midline crossing showed no significant differences (p-value = 0.137 and 0.152, respectively). At a median follow-up of 37 months, seven patients experienced relapses, and six died. The 3-year overall and event-free survival for all patients were 91% and 89%, respectively.

Conclusions
In our study, tumors larger than 12 cm and/or crossing the midline, if without other risk factors, did not significantly influence the decision for primary nephrectomy in unilateral, non-metastatic WT. However, suspicion of perinephric spread, intravascular thrombus (even at the level of renal veins), and evident retroperitoneal adenopathy were crucial factors in choosing delayed resection.
The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions
Authors: Bayoumi Dalia , Shokeir Farah Ahmed , Karam Rasha , Elraouf Ghada Hassan Abd , Ibrahim Dina Abdallah , Elboghdady Aya 
Published: February 2025

Abstract

Background
Breast cancer is a significant global health issue and is a leading cause of female deaths worldwide. Ultrasonography (US) is an adjunct technique for early diagnosis of breast cancer but has low specificity. So, researchers have suggested using US elastography to distinguish between benign and malignant breast lesions, which may lead to a decrease in unnecessary biopsy rates. We aimed to assess the diagnostic performance of strain elastography and if there was an increase in the diagnostic accuracy after adding it to conventional US results in BI-RADS 4 category breast lesions.

Results
This cross-sectional study was carried out from June 2022 to June 2024 on 240 patients with 240 breast lesions that were diagnosed as BI-RADS 4 category by conventional US. All the cases were examined using conventional US and strain elastography. Out of the 240 lesions, 107 were benign (44.6%) and 133 were malignant (55.4%). There was a significant statistical difference in the mean age of patients with benign breast lesions (37.89 ± 13.42 years) than those with malignant lesions (48.83 ± 13.65 years) (p < 0.001). Lesions’ imaging characteristics detected by conventional US as shape, margin, aspect ratio, vascularity, and calcification all showed significant differences between benign and malignant breast lesions (p < 0.001). The diagnostic accuracy of conventional US alone was 73.3% and increased to 95.3% after combining it with strain elastography. The strain elastography score has a cutoff value of 4 in discriminating malignant from benign lesions (AUC = 0.9).

Conclusions
Strain elastography provides an added diagnostic value in discriminating malignant breast lesions from benign lesions. The combination of strain elastography with US BI-RADS increases the diagnostic accuracy for the detection of malignant breast lesions which will decrease the need for unnecessary biopsy.
Flooding, Sociospatial Risk, and Population Health
Authors: Raker Ethan J. 
Published: February 2025

Abstract
Climate change and population settlement patterns are altering the severity and spatial dimensions of flooding. Despite associational evidence linking flood exposure to population health in the United States, few studies have used counterfactual strategies to address confounding or examined how sociospatial determinations of risk, such as floodplain delineation, affect well-being. Using the case of Hurricane Harvey, I leverage novel, repeated cross-sectional health survey data from Houston immediately predisaster (N = 2,540) and six to nine months postdisaster (N = 2,798), linked to local flood inundation and floodplain data. Difference-in-differences models show that the probability of psychological distress and fair/poor health increased significantly in the flooded treatment group, with mixed evidence on unhealthy mental health days and no change in unhealthy physical health days. Triple-difference estimators further reveal buffered mental health adversity for those in flooded areas with high floodplain areal coverage relative to little or no floodplains. Descriptive analyses of mechanisms suggest that floodplain coverage did not differentiate individual-level disaster exposure but increased the likelihood of disaster preparedness and evacuation. This article offers insights into the climate–health nexus empirically by using a causal framework to improve credibility and conceptually by demonstrating how an underexamined dimension of vulnerability—sociospatial risk determinations—can stratify population health.
DYNAMIC MODEL OF THE BUDGET OF AN EDUCATIONAL INSTITUTION
Authors: Ganicheva Antonina V. , Ganichev Aleksey V. 
Published: February 2025

For the study of complex socio-economic systems in a number of cases the method of mathematical modeling is the most acceptable. One of the most famous models in economics is the Keynes model. This model is most widely used in macroeconomic research to regulate the state budget. An important problem is to expand the scope of application of Keynes model by modifying it for budget management in other systems (educational organizations, family). The introduction of digitalization in the management of educational institutions necessitates new approaches to modeling the problem of calculating and optimizing the budget of an educational organization. The problem of developing a modified Keynes model for the university budget is new, important and relevant. The solution to this problem will improve the efficiency of financial management of educational institutions.
Purpose: to develop a dynamic model for distributing the budget of a university based on the modified Keynesian model.
Methodology: modeling, theory of solving differential equations.
Results: a modified Keynes model has been developed, allowing for the calculation and optimization of the budget of educational organizations.
Practical implications: the obtained results can be applied to calculate and optimize the budget of an educational institution, in the management of financial resources of organizations and enterprises.
(TRANS)FORMAÇÃO DA(S) IDENTIDADE(S) INDÍGENA(S) TRANS COLOMBIANAS
Authors: Fonseca Jonathan Nascimento , Rosa Acassia dos Anjos Santos 
Published: February 2025

O presente estudo visa (re)narrar como a(s) identidade(s) de mulher(es) indígena(s) trans são retratadas no documentário Santuário, el inesperado refugio de indígenas trans en Colombia, produzido pela BBC News em 2019. Como base epistemológica, selecionou-se os estudos decoloniais (Quijano, 1992; Maldonado-Torres, 2007 e Mignolo, 2017, 2019), bem como o Feminismo Decolonial, pensado por Lugones (2008, 2014) e os diálogos com o Transfeminismo (Nascimento, 2021) e a teoria da Interseccionalidade (Akotirene, 2023). O procedimento metodológico adotado foi a pesquisa qualitativa interpretativista (Moita Lopes, 1994), situada no campo da Linguística Aplicada. A partir das interpretações do conteúdo audiovisual, constata-se que as mulheres indígenas trans são vítimas de um processo de invisibilidade que as situam em um não-lugar, excluídas de suas comunidades de origem e da sociedade branca e cisheteropatriarcal. Destarte, as histórias dessas mulheres escancaram uma realidade invisibilizada pela modernidade/colonialidade.
Identification and Analysis of Pork Freshness Quality Based on Improved MobileNetV3
Authors: Zhou Chenggang , Pi Jie , Chen Xiao , Wang Daoying , Liu Jun 
Published: February 2025

HighlightsModel can perform pork freshness quality testing under complex lighting.MobileNetV3_E outperforms other state-of-the-art models.Model achieve an optimal balance between performance and volume.Model supports deployment on edge devices.Abstract. The accurate appraisal of freshness is influenced by the color of the meat, which is a critical indicator of pork’s freshness. However, lighting changes can also influence consumers’ perceptions of meat color. To address this issue, this study recommends a pork freshness detection method based on the lightweight MobileNetV3 model that can effectively handle interference from complex lighting environments. In this study, a lighting factor is introduced into the original dataset. The results are compared with experiments without lighting interference, showing that lighting interference leads to varying degrees of model performance degradation. This investigation introduces Efficient Channel Attention (ECA) into the MobileNetV3 model (MobileNetV3_E), redefines the h-sigmoid and h-swish activation functions, and fine-tunes the model training using the official pre-training weights to achieve the optimal balance between model performance and volume. Only the ECA module-related layers and custom fully connected layers are trained. The experimental results show that MobileNetV3_E is less affected by the lighting interference and still maintains exceptional performance on the test set, where the accuracy is 98.6%, the loss function value is 0.069, the precision is 98.6%, the recall is 98.5%, and the F1-Score is 98.5%. The MobileNetV3_E model achieves a compact size of 17.34 MB, making it suitable for deployment on resource-constrained devices. It indicates that the MobileNetV3_E model provides an efficient, reliable and easy-to-deploy solution for pork freshness detection under complex lighting conditions, which is of great application value. Keywords: Deep learning, MobileNetV3 network, Non-destructive testing, Pork freshness.
O CATOLICISMO HERÉTICO DE MURILO MENDES ATRAVÉS DAS CARTAS INÉDITAS (1930-1953) ESCRITAS PARA ALCEU AMOROSO LIMA
Authors: Salomão Khéde Raphael 
Published: February 2025

No acervo do poeta no Museu Murilo Mendes, na Universidade Federal de Juiz de Fora (UFJF), estão preservados 50 documentos, entre os quais, 39 cartas, 3 telegramas, 4 bilhetes e 3 cartões postais escritos por Murilo Mendes para Alceu Amoroso Lima, entre 1930 e 1974. A correspondência se caracteriza por dois aspectos principais entrelaçados entre si: a complexa religiosidade do autor e o envio de poemas por parte de Murilo para aquele que, ao mesmo tempo em que foi o primeiro a escrever oficialmente sobre a sua obra, era também considerado o maior crítico literário daquele momento
LLUMS I OMBRES DE LES PRIMERES TRADUCCIONS CATALANES D’ITALO CALVINO
Authors: Gavagnin Gabriella 
Published: February 2025

L’article analitza les dues primeres traduccions catalanes d’obres d’Italo Calvino, El baró rampant i El cavaller inexistent, que es van publicar respectivament el 1965 i el 1967 a la col·lecció “El Balancí” per iniciativa de Josep M. Castellet. L’una va ser encarregada a Maria Aurèlia Capmany, l’altra a Francesc Vallverdú. Després de resseguir breument el context cultural en què va madurar la iniciativa, l’article se centra en els textos des d’un punt de vista traductològic i posa en evidència les diverses estratègies adoptades així com en fa una valoració qualitativa dels resultats que té en consideració els factors lingüístics i els socioculturals.
Stochastic processes govern gut bacterial community assembly in a Schistosoma mansoni-transmitting snail, Biomphalaria straminea
Authors: Yuan Zhanhong , Hong Jinni , Khan Jehangir , Lu Jinghuang , Sanogo Benjamin , Wu Zhongdao , Sun Xi , Lin Datao 
Published: February 2025

Background
Studies have revealed extensive taxonomic classifications and patterns of gut microbial diversity in snails, with limited focus on community assembly processes. To better understand the balance between stochastic and deterministic processes in the snail gut microbial assembly and their associations with snail fitness, we used the freshwater snail Biomphalaria straminea as a model and analyzed the gut bacterial communities from 118 samples via high-throughput sequencing of the 16S rRNA gene.

Results
This study reveals that Proteobacteria and Bacteroidota dominate the gut microbiota of B. straminea. Snails from different laboratory habitats exhibit similar gut bacterial diversity but significantly different community structures. The assembly of gut bacterial communities in both laboratory and wild samples is predominantly influenced by stochastic processes rather than deterministic processes, as evidenced by the neutral community model (NCM). Furthermore, during the snail invasion and adaptation to a new environment, stochastic processes are more crucial than deterministic ones in shaping the snail gut microbiota. This indicates that the interplay between stochastic and deterministic processes in the snail gut microbial assembly is associated with host fitness during snail adaptation to a new environment. Based on the null model analysis, we also found that stochastic processes (based on dispersal limitation, homogenizing dispersal, and undominated processes) play a larger role than deterministic (based on homogeneous selection and variable selection) in driving the snail gut bacterial community assembly. Furthermore, the significant difference in the proportions of dispersal limitation and undominated processes is linked to both adaptive and non-adaptive snails.

Conclusions
This study demonstrates that stochastic processes govern the assembly of the gut microbiota in B. straminea. Furthermore, snail adaptation is associated with the interplay between stochastic and deterministic processes in gut microbial composition. This study provides a better understanding of the dynamic patterns of the gut microbial community in freshwater gastropods and may contribute to the development of strategies for controlling intermediate hosts and schistosomiasis.
Cesarean section and the gestational duration of subsequent pregnancies: A nationwide register-based cohort study
Authors: Evers Felix , Flatley Christopher , Ytterberg Karin , Juodakis Julius , Solé-Navais Pol , Jacobsson Bo 
Published: February 2025

Introduction
Preterm delivery risk is increased for women with a previous cesarean section, which are becoming more common worldwide. However, this risk is based on studies which have not fully accounted for selection bias, and the studied outcomes have been limited to the study of early deliveries. This study aimed to determine the impact of previous delivery modes on the incidence of deviant duration of subsequent pregnancies.

Material and methods
This retrospective cohort study used clinical data registered in the Swedish Medical Birth Register. 612 935 women with their first two pregnancies and 157 581 women with their first three pregnancies were included. The outcome was the gestational duration of the last pregnancy of the series, depending on previous delivery modes. The associations were analysed with multivariable logistic regression (with the gestational duration categorised) and survival models including Cox regression analyses.

Results
When using standard logistic regression, previous cesarean section was associated with an increased risk of both spontaneous preterm birth (adjusted odds ratio [aOR] 1.67, 95% CI 1.57–1.77) and postterm birth (aOR 1.55, 95% CI 1.49–1.62). However, the more appropriate survival models only showed an association between cesarean section and longer gestational duration of the subsequent pregnancy (adjusted hazard ratio 0.72, 95% CI 0.71–0.73).

Conclusions
The survival model handles bias related to management differences between the exposure and reference groups better than standard logistic regression, making it the statistical method of choice when conducting studies on this research topic. This study shows that the main association between cesarean section and the gestational duration of the subsequent pregnancy is the prolonging of it, which stands in contrast with previous research on the topic.