bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is YouTube Propagating Concerns About Breast Implant Illness?
Authors: Herzog Isabel , Pandher Meher , Mansukhani Priya A. , Kapadia Kailash , Lee Edward S. 
Published: January 2024

Background
An increasing number of patients who underwent breast implant surgery are reporting a cluster of concerning physical and psychological symptoms—newly coined term breast implant illness (BII). YouTube is a popular educational tool for plastic surgery patients.

Objectives
The purposes of this study were to assess the quality and reliability of YouTube videos on BII, compare the quality and reliability of different video categories and publishers, and determine the frequencies of reported BII symptoms.

Methods
On YouTube, videos were searched for the term breast implant illness, and the first 100 results were collected. Engagement parameters and symptoms of BII mentioned in each video were recorded. Video power index, a modified DISCERN instrument, and the Global Quality Scale (GQS) were used to assess popularity, reliability, and quality, respectively.

Results
Ninety videos met the inclusion criteria. More than half mentioned fatigue (66%), cognitive dysfunction (59%), or muscle and/or joint pain (57%). Videos with a plastic surgeon present had higher DISCERN (P = 0.001) and GQS (P = 0.002) scores than those without. Educational videos had higher DISCERN and GQS scores than patient experience (P < 0.0001, P = 0.001) and entertainment and advertisement videos (P = 0.014, P = 0.022). Videos published by plastic surgeons had higher Video power index (P = 0.033), DISCERN (P < 0.0001), and GQS scores (P < 0.0001) than those by nonmedical publishers.

Conclusions
The top YouTube videos for BII are generally of low reliability and low-to-moderate quality. Patients unaware of YouTube's limited quality control measures for health education videos are susceptible to misinformation. Additional social media content created by plastic surgeons can improve the quality and accuracy of videos viewed by patients.
Clinical and Histological Response to Talimogene Laherparepvec Therapy in Advanced Melanoma: Impact on Overall Survival
Authors: Ologun Gabriel O , Jones C Paige , Landrum Kelsey R , Pham P Veronica , Ismail Sherin , Long Patricia K , Sorah Jonathan D , Stitzenberg Karyn B , Meyers Michael O , Ollila David W 
Published: January 2024

BACKGROUND:
Talimogene laherparepvec (T-VEC) is an FDA-approved oncolytic herpesvirus therapy used for unresectable stage IIIB through IV metastatic melanoma. However, the correlation between clinical complete response (cCR) and pathologic complete response (pCR) in patients treated with T-VEC is understudied.

STUDY DESIGN:
We conducted a retrospective study from a prospectively maintained IRB-approved melanoma single-center database in patients treated with T-VEC from October 2015 to April 2022. Patients were categorized into 3 groups: cCR with pCR, cCR without pCR, and less than cCR. The primary endpoint was overall survival. We used descriptive statistics, chi-square tests, and Wilcoxon rank-sum tests to compare key covariates among exposure groups. We used survival analysis to compare survival curves and reported hazard ratio of death (95% CI) across exposure groups.

RESULTS:
We included 116 patients with a median overall survival (interquartile range) of 22.7 (14.8–39.3) months. The majority were men (69%) and White (97.4%), with a median age of 74.5 years. More than half of patients (n = 60, 51.6%) achieved cCR. Distribution among the groups was as follows: cCR with pCR (35.3%), cCR without pCR (16.3%), and less than cCR (48.4%). Median overall survival time (interquartile range) was 26.5 (18.6–36.0) months for cCR with pCR, 22.7 (14.4–35.5) months for cCR without pCR, and 17.8 (9.2–47.0) months for less than cCR (log-rank p value = 0.0033).

CONCLUSIONS:
Patients achieving cCR with pCR after T-VEC therapy have the most favorable overall survival outcomes, whereas those achieving cCR without pCR have inferior survival and those achieving less than cCR have the poorest overall survival outcomes. These findings emphasize the importance of histological confirmation and provide insights for optimizing T-VEC therapy in patients with advanced melanoma.
Operating Room Supply Cost and Value of Care after Implementing a Sustainable Quality Intervention
Authors: Filiberto Amanda C , Loftus Tyler J , Crippen Cristina J , Hu Die , Balch Jeremy A , Efron Philip A , Sarosi George A , Upchurch Gilbert R 
Published: January 2024

BACKGROUND:
Variability in operating room supply cost is a modifiable cause of suboptimal resource use and low value of care (outcomes vs cost). This study describes implementation of a quality improvement intervention to decrease operating room supply costs.

STUDY DESIGN:
An automated electronic health record data pipeline harmonized operating room supply cost data with patient and case characteristics and outcomes. For inpatient procedures, predicted mortality and length of stay were used to calculate observed-to-expected ratios and value of care using validated equations. For commonly performed (1 or more per week) procedures, the pipeline generated figures illustrating individual surgeon performance vs peers, costs for each surgeon performing each case type, and control charts identifying out-of-control cases and surgeons with more than 90th percentile costs, which were shared with surgeons and division chiefs alongside guidance for modifying case-specific supply instructions to operating room nurses and technicians.

RESULTS:
Preintervention control (1,064 cases for 7 months) and postintervention (307 cases for 2 months) cohorts had similar baseline characteristics across all 16 commonly performed procedures. Median costs per case were lower in the intervention cohort ($811 [$525 to $1,367] vs controls: $1,080 [$603 to $1,574], p < 0.001), as was the incidence of out-of-control cases (19 (6.2%) vs 110 (10.3%), p = 0.03). Duration of surgery, length of stay, discharge disposition, and 30-day mortality and readmission rates were similar between cohorts. Value of care was higher in the intervention cohort (1.1 [0.1 to 1.5] vs 1.0 [0.2 to 1.4], p = 0.04). Pipeline runtime was 16:07.

CONCLUSIONS:
An automated, sustainable quality improvement intervention was associated with decreased operating room supply costs and increased value of care.
Hyperboloidal approach for static spherically symmetric spacetimes: a didactical introduction and applications in black-hole physics
Authors: Panosso Macedo Rodrigo 
Published: January 2024

This work offers a didactical introduction to the calculations and geometrical properties of a static, spherically symmetric spacetime foliated by hyperboloidal time surfaces. We discuss the various degrees of freedom involved, namely the height function, responsible for introducing the hyperboloidal time coordinate, and a radial compactification function. A central outcome is the expression of the Trautman–Bondi mass in terms of the hyperboloidal metric functions. Moreover, we apply this formalism to a class of wave equations commonly used in black-hole perturbation theory. Additionally, we provide a comprehensive derivation of the hyperboloidal minimal gauge, introducing two alternative approaches within this conceptual framework: the in-out and out-in strategies. Specifically, we demonstrate that the height function in the in-out strategy follows from the well-known tortoise coordinate by changing the sign of the terms that become singular at future null infinity. Similarly, for the out-in strategy, a sign change also occurs in the tortoise coordinate’s regular terms. We apply the methodology to the following spacetimes: Singularity-approaching slices in Schwarzschild, higher-dimensional black holes, black hole with matter halo, and Reissner–Nordström–de Sitter. From this heuristic study, we conjecture that the out-in strategy is best adapted for black hole geometries that account for environmental or effective quantum effects.This article is part of a discussion meeting issue ‘At the interface of asymptotics, conformal methods and analysis in general relativity’.
IN SILICO DESIGN AND BINDING MECHANISM OF E3 LIGASE UBR1 RECRUITERS
Authors: Maria-Solano Miguel A. , Lazim Raudah , Choi Sun 
Published: January 2024

ABSTRACTProteolysis Targeting Chimeric Molecules (PROTACs) represent a promising avenue in drug discovery, as they can induce the targeted degradation of disease-relevant proteins within the cellular machinery. These compounds comprise a ligand tailored to bind the specific targeted protein connected to a recruiter molecule that engages with the E3 ligase. Despite their promise as therapeutic agents, their clinical advancement has encountered substantial challenges, primarily due to the limited availability of suitable E3 ligases. Additionally, cell permeability and proteolytic stability due to their peptide nature often hamper their application. In this study, we focus on the development of recruiters for the E3 ligase UBR1. This widely expressed protein has recently been demonstrated to be efficient in driving the degradation of oncogenic proteins. Our computational approach leverages a fragment-based peptidomimetics strategy, integrating pharmacophore filtering, docking, and fragment-linking optimization. Finally, we subject the wild-type peptide and the most promising combined fragments to advanced binding free energy calculations, unveiling insights into their dynamic water-mediated binding mechanisms and their potential as robust E3 ligase UBR1 recruiters, ultimately leading to the identification of promising compounds. This computational workflow is readily applicable to the development of related PROTACs and also to model protein-protein interactions with similar characteristics.
Differences between volatiles that affect the attraction of different Rosa chinensis (Rosales: Rosaceae) cultivars for Frankliniella intonsa (Thysanoptera: Thripidae)
Authors: Zeng Li , Yang Yuping , Li Shuai , Wang Zhaocui , Meng Yonglu , Wei Shuangfei , Maggi Filippo , Cao Yu 
Published: January 2024

AbstractFrankliniella intonsa Trybom is a common flower‐inhabiting thrips species and an economically important pest of numerous horticultural and agricultural crops. Olfactory cues are important for thrips to find host plants. In this study, the olfactory behavioral responses of F. intonsa to volatiles from five Rosa chinensis cultivars (Samantha, Zeprti, Queen Elizabeth, Golden Scepter, and Witte Koster) were tested in Y‐tube and six‐arm olfactometer experiments. Then the volatile components of the R. chinensis flowers were analyzed by SPME coupled with gas chromatography–mass spectrometry (GC–MS). Both female and male thrips showed significant preferences for volatiles from the five R. chinensis cultivars compared with clean air (CA). However, according to the six‐arm olfactometer bioassays, female F. intonsa adults were better than male thrips at recognizing the odor stimulation and showed the strongest olfactory preference for Samantha, followed by Zeprti, Queen Elizabeth, Golden Scepter, and then Witte Koster. SPME‐GC–MS analysis identified 56, 53, 53, 57, and 60 components in the volatile profiles of Samantha, Zeprti, Queen Elizabeth, Golden Scepter, and Witte Koster, respectively. Eugenol (12.53%) was the most abundant volatile compound in cultivar Witte Koster, ɑ‐pinene was the most abundant compound in Samantha (18.26%) and Zeprti (23.73%), and phenylethyl alcohol was the most abundant in Queen Elizabeth (30.10%) and Golden Scepter (31.33%). Therefore, the olfactory responses of F. intonsa to different R. chinensis cultivars demonstrated that host‐related volatiles play an important role in thrip host‐searching. Future mitigation approaches, for example, attractant traps, could still be used for key monitoring and control of this pest.
A review of food safety in low‐moisture foods with current and potential dry‐cleaning methods
Authors: Karuppuchamy Veeramani , Heldman Dennis R. , Snyder Abigail B. 
Published: January 2024

AbstractFood is one of the basic needs of human life. With the increasing population, the production and supply of safe and quality foods are critical. Foods can be classified into different categories including low moisture, intermediate moisture, and high moisture content. Historically, low‐moisture foods have been considered safe for human consumption due to the limited amount of moisture for microbial activity. Recalls of these foods due to pathogens such as Salmonella and undeclared allergens have brought attention to the need for improved cleaning and sanitization in dry food manufacturing facilities. In the food industry, cleaning and sanitation activities are the most efficient methods to prevent microbial contamination; however, water is most often required to deliver cleaning and sanitation agents. A well‐written and properly implemented sanitation standard operating procedure can take care of microbial and allergen cross‐contamination. Nevertheless, there are unique challenges to cleaning and sanitation processes for low‐moisture food manufacturing facilities. The introduction of moisture into a low‐moisture food environment increases the likelihood of cross‐contamination by microbial pathogens. Hence, the use of water during cleaning and sanitation of dry food manufacturing facilities should be limited. However, much less research has been done on these dry methods compared to wet sanitation methods. This review discusses recent foodborne outbreaks and recalls associated with low‐moisture foods the accepted methods for cleaning and sanitation in dry food manufacturing facilities and the limitations of these methods. The potential for air impingement as a dry‐cleaning method is also detailed.
The role of target difficulty and career tournaments in retaining creative R&D employees
Authors: Grabner Isabella , Seiter Mischa , Wabnegg Markus , Wirth Henning 
Published: January 2024

AbstractWe explore the turnover intentions of creative R&D employees and the role of performance management practices in shaping these considerations. Since the success of a firm's R&D efforts hinges on the innovative ideas of its employees, it is crucial to retain particularly creative individuals. At the same time, however, we argue that this is especially difficult because both the higher outside options of creative employees and their specific individual characteristics make them, on average, more likely to leave their company. Most importantly, we suggest that two widely studied performance management design choices (target difficulty and career tournaments) typically used to motivate effort may influence the loss of creative talent. Using survey data from our unique access to R&D employees of a large manufacturing firm and a complementary experiment among business students, we find evidence that creative employees are, on average, more likely to leave their firm. Consistent with creative employees possessing a stronger learning orientation, we also predict and find that this tendency to leave is mitigated by target difficulty (as difficult targets speak to creative individuals' learning orientation) and exacerbated by the intensity of career tournaments (as they reduce team cohesion and, ultimately, undermine learning opportunities).
Navigating through the noise: The effect of color‐coded performance feedback on decision‐making
Authors: Cardinaels Eddy , Kramer Stephan , Maas Victor S. 
Published: January 2024

AbstractMany companies use color codes in their internal performance reports to highlight how current performance compares to performance in a previous period. We examine whether the use of color coding affects managers' decision‐making in a resource allocation task. We argue that managers' decision accuracy will be lower if they receive noisier feedback, but that this detrimental effect of noise can be mitigated through color coding. Using two experiments, we find evidence consistent with our theory. Managers who receive reports in which performance increases are color‐coded green and performance decreases are color‐coded red are less affected by noise than managers who receive feedback reports without color coding. Supplemental analyses suggest that color coding induces managers to process feedback in a more holistic manner, which reduces the adverse effect of noise on managers' learning processes. Our findings have several important implications for research and practice.
The predictive value of serum IL‐17A and IL‐6 expression in postoperative recurrence in patients with intrauterine adhesion
Authors: Cui Xia , Xiao Hui‐Chao , Pan Wen 
Published: January 2024

AbstractBackgroundThe recurrence rate of intrauterine adhesions (IUA) was high. At present, there are few studies on the relationship between proinflammatory factors IL‐17A and IL‐6 and IUA. The expression of serum IL‐17A and IL‐6 in IUA patients and their predictive value for postoperative recurrence were retrospectively analyzed.MethodsA total of 90 IUA patients who underwent hysteroscopic adhesion lysis in our hospital from January 2020 to January 2023 were selected as the IUA group. Patients were divided into mild, moderate, and severe IUA groups. At the same time, 60 cases of secondary infertility patients with normal endometrium were selected as the control group. The clinical baseline characteristics and serum levels of IL‐17A and IL‐6 were compared between control group and IUA group. To analyze the correlation and predictive value of IL‐17A and IL‐6 expression levels with the recurrence rate of IUA patients.ResultsThe preoperative levels of IL‐17A and IL‐6 in the IUA group were significantly higher than those in the control group. The higher the levels of inflammatory factors IL‐17A and IL‐6, the deeper the degree of IUA. Multivariate analysis showed that pregnancy, curettage history, IL‐17A, and IL‐6 levels were risk factors for IUA recurrence. In addition, the specificity and area under the curve of combining baseline data with postoperative serum IL‐17A and IL‐6 for predicting IUA were higher than those predicted separately.ConclusionThe expression levels of serum IL‐17A and IL‐6 can be used as a value index to evaluate postoperative recurrence in IUA patients.
Exchange rates and political uncertainty: the Brexit case
Authors: Manasse Paolo , Moramarco Graziano , Trigilia Giulio 
Published: January 2024

AbstractThis paper studies the impact of political risk on exchange rates. We focus on the Brexit Referendum as it provides a natural experiment where both exchange rate expectations and a time‐varying political risk factor can be measured directly. We build a portfolio model that relates changes in the Leave probability to changes of the British pound's market price, both via expectations and via a political risk factor. We estimate the model for multilateral and bilateral British pound exchange rates. We find that the Leave probability predicts a depreciation of the pound, consistent with the outcome post‐referendum, and that the time‐varying political risk affects exchange rates independently.
Effect of BN interfacial layer on the mechanical behavior of SiC fiber reinforced SiC ceramic matrix composites
Authors: Chen Mingwei , Qiu Haipeng , Zhao Yuliang , Zhang Bingyu , Liu Shanhua , Luo Wendong , Ma Xin , Xie Weijie , Chen Yi , Zhang Qiyue , Zhao Yuliang 
Published: January 2024

AbstractBoron nitride (BN) interfacial layer with controlled thickness and structure was prepared on the surface of near stoichiometric ratio SiC fiber preforms by a chemical vapor deposition process, and the SiC/SiC composites were obtained by polymer precursor infiltration and pyrolysis process. The microstructure of the BN interfacial layer and SiC/SiC composites was tested by scanning electron microscopy, and the mechanical behavior of SiC/SiC composites was characterized by a mechanical properties test. Results showed that BN interfacial layer was evenly distributed in the fiber preforms with excellent thickness consistency. As the thickness of the BN interfacial layer increased, the deflection path of the crack increased gradually, resulting in the flexural strength first increasing and then decreasing. The mechanical behavior mentioned above was mainly attributed to the dual effects of load transfer and crack propagation of the BN interfacial layer; that was, the crack propagation of ceramic matrix under external load lengthened the path of load transfer and formed a large number of fibers bridging and pulling out successively, which contributed to the energy dissipation mechanism.
Serum lipase in acute pancreatitis associated with hypertriglyceridaemia
Authors: Morton Adam 
Published: January 2024

AbstractThe incidence of hypertriglyceridaemic pancreatitis is increasing. Hypertriglyceridaemia may be associated with false lowering of serum amylase and lipase in vitro. A retrospective study of serum lipase levels in 26 individuals who had acute pancreatitis diagnosed based on clinical criteria together with changes on computer tomography in the setting of severe hypertriglyceridaemia over a 5‐year period from January 2017 to December 2021 was performed. Serum lipase levels were in the normal range in two patients (7.7%) and less than three times the upper end of the reference interval in 11 individuals (42%). Awareness of the potential for normal and nonsignificantly elevated serum lipase levels in the setting of hypertriglyceridaemic pancreatitis is important to avoid a missed diagnosis, to enable appropriate short‐ and long‐term management and to prevent recurrent episodes.
Manifestation of chemical pressure: Magnetism and magnetostriction in nanoscale RFeO3 (R = Sm, Dy, Ho, and Lu)
Authors: Chaturvedi Smita , Shyam Priyank , Liu Ying , Srinivasan Gopalan 
Published: January 2024

AbstractThe effect of ionic radii sizes on magnetostriction is studied in relation to structural and magnetic properties. To explore the effect of the chemical pressure, nanoparticles of rare‐earth (RE) orthoferrites, SmFeO3, DyFeO3, HoFeO3, and LuFeO3 are studied using X‐ray diffraction, field emission scanning electron microscopy, and Raman spectroscopy. Magnetic and magnetostriction measurements are also performed. In these orthoferrites, the coordination of the RE ion is eightfold, whereas the RE ionic radii are significantly different, which directly influences the structural parameters. The distortion of FeO6 octahedra is observed as a result of changing chemical pressure within the lattice. The different magnitudes of magnetostriction in RE orthoferrites can be attributed to the different degrees of distortion of FeO6 octahedra, R–O dynamics, and spin–orbit interactions in the system. The maximum value of magnetostriction (∼ 19 ppm) and magnetization at 2 K (30.64 emu/g) is demonstrated by HoFeO3. Comparison of structural parameters of the samples to their respective bulk counterparts indicated relative structural distortion in nanoparticles.