bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced dynamic fine‐grained popularity‐based caching algorithm for ICN‐based edge computing networks
Authors: Banerjee Supratik , Biswash Sanjay Kumar 
Published: January 2024

AbstractIn this letter, we propose an Enhanced Dynamic Fine‐Grained Popularity‐based Caching (ED‐FGPC) algorithm to efficiently cache static contents in ICN‐based edge computing networks. The content popularity changes with time. Thus, the ED‐FGPC algorithm considers the number of incoming interests, the practical file size, and the available cache size to adjust the content popularity threshold. This allows dynamic adjustment of the content popularity threshold. Additionally, ED‐FGPC incorporates a single bit called cached bit (CB) in the header field of the content. This eliminates caching redundancy in the on‐path routers. The cache eviction policy jointly considers the content popularity and the average content access timestamp for content replacement. Based on the content access pattern, this allows finer adjustment of the content eviction policy. We use analytical and mathematical modeling to derive the effectiveness and efficiency of our contribution. Results present a better hit ratio due to dynamic adjustment of the content popularity threshold and the elimination of caching redundancy from the on‐path routers.
A quantitative and qualitative analysis of a medication health literacy workshop for newly and recently arrived refugees
Authors: Prescott Gina M. , Karunakaran Shakanya , Thandar May 
Published: January 2024

AbstractIntroductionRefugees entering the United States are often unfamiliar with the healthcare system and have different medication beliefs. Since 2016, pharmacy students and faculty have been conducting medication literacy workshops to improve knowledge of medications for newly arriving refugees.ObjectivesThe primary study objective was to measure the newly arriving refugees' medication knowledge after a one‐time educational workshop.MethodsThis was a retrospective quantitative and qualitative evaluation. Participants engaged in a student‐led 90‐min educational workshop utilizing interpreters, translated materials, and demonstrations. Topics included medical definitions, information on getting sick, medication use, and label reading. A translated, postworkshop evaluation included 22 questions grouped into the following categories: demographics (n = 4), medication use (n = 7), label reading (n = 6), access (n = 3), and cultural beliefs (n = 2). Three optional, free‐response questions regarding overall workshop feedback were included. Quantitative data was analyzed utilizing descriptive statistics. Thematic analysis was used to analyze qualitative data. Two independent coders reviewed each free‐response question and discussed any discrepancies for consensus. The study team developed key themes based on the codes.ResultsTwenty‐one workshops were conducted with 419 participants from 42 countries. Correct responses were highest for medication beliefs (84%), label reading (78%), access (74%), and medication use (73%). Prescription label reading ability was high (86%), while preventative medicine understanding was lower (34%). Three major learning themes developed, including (1) Cultural differences impact medication habits, (2) Knowing provider roles and how to access different services in healthcare settings was important, and (3) Understanding how to read a label was useful. Researchers found that demonstrations were helpful in participants' learning and that additional education on prevention and specific disease states would be useful.ConclusionNewly and recently arrived refugees were able to correctly identify basic medication health information through a medication literacy workshop. Additional classes exploring other topics, including preventative medicine and medications, should be considered.
Relief of Residual Stress in Bulk Thermosets in the Glassy State by Local Bond Exchange
Authors: Wu Kangning , An Dongxu , Zhang Zhuolin , Zhao Ge , Cui Chenhui , Zhou Fusheng , Li Jianying 
Published: January 2024

AbstractThe covalently cross‐linked network gives thermosets superior thermal, mechanical, and electrical properties, which, however, squarely makes the large residual stress that is inevitably induced during preparation hardly relieved in the glassy state. In this work, an incredible reduction in residual stress is successfully achieved in bulk thermosets in the glassy state through introducing highly dynamic thiocarbamate bonds by “click” reactions of thiols and isocyanates. Due to the excellent dynamic behaviors of thiocarbamate bonds, local network rearrangement is achieved through thermal stimulation, while the strong 3D cross‐linked network is well maintained. Ultimately, a decrease by 44% in residual stress is detected by simply annealing samples at 30 °C below glass transition temperature (Tg), during which they could well maintain more than 98.4% of the storage modulus. After the annealing, more uniform residual stress distribution is also observed, showing a 32% decline in sample standard deviation. However, the residual stress of epoxy resin, a typical thermoset as a reference, changes little even after annealing at Tg. The results prove it a feasible strategy to reduce residual stress in bulk thermosets in the glassy state by introducing proper dynamic covalent bonds.
Intertribal Talking Circle for the prevention of alcohol and drug use among Native American youth
Authors: Lowe John , Brooks Jada , Lawrence Gary , Baldwin Julie A. , Kelley Melessa , Wimbish‐Tompkins Rose 
Published: January 2024

AbstractThe purpose of this study was to examine the impact of a culturally based intervention, the Intertribal Talking Circle program, compared to a standard alcohol and drug abuse education, the Be A Winner program. Community‐based participatory research was used to implement a two‐condition, quasi‐experimental study. The sample included 540 Native American youth ages 10−12 years old from three tribal areas in the United States. Data were collected at baseline, 6 and 12‐months post‐intervention for both the intervention and control groups using demographic, cultural identity, alcohol use, and drug use questionnaires. Regression models evaluated participants' improvement in decreasing alcohol and drug use and increasing cultural identity. Findings revealed that alcohol and drug use decreased more significantly among youth who participated in the Intertribal Talking Circle (ITC) intervention program than youth who participated in a standard alcohol and drug abuse education Be A Winner (BAW) program. Cultural identity also increased more significantly among participants who completed the Talking Circle intervention program. Native American youth ages 10−12 years old respond positively to a culturally based intervention for the reduction of alcohol and drug use. The findings highlight the importance of cultural values and identity and their significance in preventing and reducing alcohol and drug use among Native American youth.
Privacy‐preserving credit risk analysis based on homomorphic encryption aware logistic regression in the cloud
Authors: Divakar Allavarpu V. V. L. , Naresh Vankamamidi S. , Krishna Mohan A. 
Published: January 2024

AbstractWith the growing significance of Credit Risk Analysis (CRA) with a focus on privacy, there is a pressing demand for a Privacy Preserving Machine Learning (PPML) decision support system. In this context, we introduce a framework for privacy‐preserving credit risk analysis that utilizes Homomorphic Encryption aware Logistic Regression (HELR) on encrypted data. The implementation involves the use of TenSEAL and Torch libraries for Logistic Regression (LR), integrating the proposed HELR on polynomial degrees 3 and 5 across German, Taiwan, Japan, and Australian datasets. The presented model yields satisfactory results compared to non‐Homomorphic Encryption (HE) models, demonstrating a minimal accuracy difference ranging from 0.5% to 7.8%. Notably, HELR_g5 outperforms HELR_g3, exhibiting a higher Area Under Curve (AUC) value. Additionally, a thorough security analysis indicates the resilience of the proposed system against various privacy attacks, including poison attacks, evasion attacks, member inference attacks, model inversion attacks, and model extraction attacks at different stages of machine learning. Finally, in the comparative analysis, we highlight that the proposed model ensures data privacy, encompassing training privacy and model privacy during the training phase, as well as input and output privacy during the inference phase a level of privacy not achieved by existing systems.
The effect of cortisol on equine monocyte–derived dendritic cell phenotype and cytokine production
Authors: Lopez Brina S. , Hurley David J. , Giancola Shyla , Giguère Steeve , Hart Kelsey A. 
Published: January 2024

AbstractBackgroundIncreased risk of infection in neonates, including foals, is associated with the naivety of the immune system and the immaturity of the endocrine system. Foal dendritic cells (DCs) are phenotypically and functionally less mature than adult horse DCs. Exposure of foal DCs to foal plasma alters DC phenotypic maturation, cytokine secretion and bacterial endocytosis. Specific plasma factors that impact equine DC activity are unknown. Endocrine dysfunction, resulting in altered cortisol availability, is common in foals. Cortisol impacts DC maturation and function in other species, but the effect of cortisol on equine DCs is not described. We hypothesized that exposure to cortisol would impact both the phenotype and function of equine monocyte–derived DCs (MoDCs), perpetuating an immature phenotype and altered cytokine profile.MethodsMoDCs were generated from foals (n = 8) on 1, 7 and 30 days of age and adult horses (n = 9). MoDCs were exposed to killed bacteria in the presence or absence of cortisol. The expression of surface markers (MHC class‐II, CD86 and CD14) was measured by flow cytometry. Supernatant cytokine concentrations (IL‐4, IL‐17, IFN‐γ and IL‐10) were quantified using a validated bead‐based immunoassay.ResultsCortisol exposure reduced the percentage of equine MoDCs expressing MHC class‐II and CD86 (p ≤ 0.03). Adult horse MoDCs exposed to bacteria and cortisol produced less IL‐4, IL‐17, IFN‐γ and IL‐10 than cells not treated with cortisol, and foal MoDCs secreted less IL‐10 and IL‐4 (p ≤ 0.009).ConclusionsIn sum, cortisol exposure perpetuates an immature MoDC phenotype and alters cytokine responses, which might impact the foal's susceptibility to infection.
Can the rigid stylet from an intravenous catheter be an alternative vascular access device for intraosseous catheterisation?
Authors: Kim Janghwan , Kim Daesik , Seo Daeyun , Hwang Hyejin , Kim Yuna , Chung Taekyu , Lim Seongsoo , Lee Hansol , Namgoong Beomkwan , Choe Ahreum , Hong Hyeajeong , Umh Heesung , Kim Min Su 
Published: January 2024

AbstractBackgroundIt may be challenging for practitioners to secure vascular access in animals, especially in a state of shock.AimThis study aimed to evaluate the clinical relevance of commercial 16‐gauge intravenous (IV) catheter stylet vs. 15‐gauge intraosseous (IO) vascular access in emergencies.MethodsSix healthy dogs were used in this study. After general anaesthesia, IO catheterisation was performed on both trochanteric fossae of the femurs using a commercial 16‐gauge IV catheter stylet and EZIO 15‐gauge IO needle. The pressures were measured by manual, gravity and mechanical infusion for 5 min each. Additionally, insertion time and success rate were recorded.ResultsIn hand infusion, mean pressure of a 16‐gauge IO (605.06 ± 49.13 mmHg) was statistically lower than that of a 15‐gauge EZIO IO catheterisation (718.84 ± 93.09 mmHg). In gravity infusion, there was no significant difference in pressure during injection between the 16‐gauge IV catheter (52.23 ± 14.48 mmHg) and 15‐gauge EZIO IO catheterisation (50.68 ± 11.89 mmHg). In mechanical infusion, mean pressure of the 15‐gauge EZIO IO catheterisation (128.25 ± 50.16 mmHg) was lower than that of the 16‐gauge IV catheter (152.56 ± 67.23 mmHg). The insertion times of a 16‐gauge IV catheter and 15‐gauge EZIO IO catheterisation were 16.79 ± 0.92 and 11.65 ± 1.70 s, respectively. The success rates of the insertion were similar between both groups.ConclusionThis study shows that IO catheterisation with a commercial IV catheter stylet can be an alternative method of IO catheterisation in an emergency, especially for rapid vascular access.
GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression
Authors: Kang Hong Soon , Grimm Sara A. , Liao Xiao-Hui , Jetten Anton M. 
Published: January 2024

AbstractLoss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at E15.5 of murine thyroid development, a time at which GLIS3 target genes, such as Slc5a5 (Nis), become expressed. This, together with observations showing that ubiquitous Glis3KO mice do not display major changes in prenatal thyroid gland morphology, indicated that CH in Glis3KO mice is due to dyshormonogenesis rather than thyroid dysgenesis. Analysis of GLIS3 in postnatal thyroid suggested a link between GLIS3 protein expression and blood TSH levels. This was supported by data showing that treatment with TSH, cAMP, or adenylyl cyclase activators or expression of constitutively active PKA enhanced GLIS3 protein stability and transcriptional activity, indicating that GLIS3 activity is regulated at least in part by TSH/TSHR-mediated activation of PKA. The TSH-dependent increase in GLIS3 transcriptional activity would be critical for the induction of GLIS3 target gene expression, including several thyroid hormone (TH) biosynthetic genes, in thyroid follicular cells of mice fed a low iodine diet (LID) when blood TSH levels are highly elevated. Like TH biosynthetic genes, the expression of cell cycle genes is suppressed in ubiquitous Glis3KO mice fed a LID; however, in thyroid-specific Glis3 knockout mice, the expression of cell cycle genes was not repressed, in contrast to TH biosynthetic genes. This indicated that the inhibition of cell cycle genes in ubiquitous Glis3KO mice is dependent on changes in gene expression in GLIS3 target tissues other than the thyroid.
Effect of wood moisture content and adhesive open time on the adhesion strength of wet bonded Pinus radiata wood
Authors: Favis Jesse , Balboni Bruno Monteiro , Wessels C. Brand 
Published: January 2024

AbstractGluing wood in the wet state can reduce warping, splitting, and increase processing volume recovery. Adhesive open time and moisture content may play an important role in bond line strength, but there are no specifications for wet wood bonding. Wood specimens at two different moisture contents were glued with three polyurethane adhesives and tested in shear on the bond line. Open time of 15 min was superior to 4 and 40 min. All adhesives performed better when wood was glued at 30% moisture content than at 101%, but only the 15- and 40-min open time met the minimum shear requirement.
Larger Common River Frogs (Amietia delalandii) have Fewer and Shorter Tissue Microplastic Fibres than Smaller Frogs
Authors: Burger Mari , Bouwman Hindrik , du Preez Louis H. , Landman Willie 
Published: January 2024

AbstractLittle is known about microplastics (MPs) in adult frogs. We investigated MPs in adult Common River Frogs (Amietia delalandii) from Potchefstroom, South Africa. Five kinds of samples were analysed: natural water, water used to rinse the skin, skin, intestine, and the remainder of the body (corpus). Tissues were digested. Microplastics occurred in all frogs and sample types (1128 MPs counted). Fibres were the most prevalent MP. Fibre lengths were between 28 and 4300 μm, either polyester or polyvinyl alcohol. MPs in skin were likely derived from the ambient, and MPs in the corpus from translocation via the skin. Fibres in tissues were significantly shorter in larger frogs, a phenomenon we provisionally assign to in situ biodegradation. Microplastics in frogs can potentially be transferred through the food web to higher trophic levels. This study provides the first evidence of MPs in adult frog tissues and avenues for further investigations.
Graphical Abstract
Low soil Moisture Slows Uptake and Elimination Rates of Phenanthrene in Springtails
Authors: Wang Yang , Slotsbo Stine , Sørensen Peter B. , Holmstrup Martin 
Published: January 2024

AbstractThis study investigated the influence of soil water status on the toxicokinetics of phenanthrene in the springtail Folsomia candida allowing estimation of uptake and elimination rates at two contrasting soil water potentials. Fitting a three-phase model to the observations showed that uptake rate (ku) was almost two times higher in moist soil (-2 kPa) than in dry soil (-360 kPa). During the first days of the exposure, elimination rate (ke) was not significantly different in moist and dry soil, but after eight days ke had increased significantly more in moist soil than in dry soil. Our results confirm the general notion that the exposure route via soil pore water is important. Understanding the significance of soil moisture in exposure and effects of contaminants on soil invertebrates is crucial for assessing the ecological risks associated with soil pollution in a changing climate.
Affective neuroscience theory and attitudes towards artificial intelligence
Authors: Montag Christian , Ali Raian , Davis Kenneth L. 
Published: January 2024

Abstract
Artificial intelligence represents a key technology being inbuilt into evermore products. Research investigating attitudes towards artificial intelligence surprisingly is still scarce, although it becomes apparent that artificial intelligence will shape societies around the globe. To better understand individual differences in attitudes towards artificial intelligence, the present study investigated in n = 351 participants associations between the Affective Neuroscience Personality Scales (ANPS) and the Attitudes towards Artificial Intelligence framework (ATAI). It could be observed that in particular higher levels of SADNESS were associated with higher negative attitudes towards AI (fearing AI). The findings are discussed in this work from an evolutionary perspective because primary emotional systems—according to Affective Neuroscience Theory—represent tools for survival, which have been homologously conserved across mammalian species including homo sapiens.
A comprehensive pan-cancer analysis of prognostic value and potential clinical implications of FTH1 in cancer immunotherapy
Authors: Luo Yuejun , Liu Chengming , Yao Yuxin , Tang Xiaoya , Yin Enzhi , Lu Zhiliang , Sun Nan , He Jie 
Published: January 2024

Abstract
Background
Numerous studies have highlighted the crucial value of the heavy chain of ferritin (FTH1) as a key regulator of iron metabolism and a suppressor of ferroptosis, intimately tied to the tumor immune microenvironment (TIME). Nevertheless, the precise impact of FTH1 on cancer immunotherapy remains vague. Our study aims to systematically explore the prognostic significance and immune role of FTH1 in pan-cancers immunotherapy.

Methods
Our study delves into the potential of FTH1 as an immunotherapeutic target within the TIME of various solid cancers. The immune landscape and underlying mechanisms of FTH1 in the TIME were investigated by multiple algorithms and bioinformatics methods. Single-cell sequencing analysis and multiplex immunofluorescence staining techniques are applied to observe FTH1 co-expression on both tumor and immune cells.

Results
FTH1 exhibited aberrant expression patterns across multiple cancers, which is strongly correlated with immunotherapy resistance. Patients with high FTH1 expression levels tended to derive less benefit from immunotherapies. Moreover, FTH1 demonstrated a significant correlation with TIME infiltration, immune checkpoint molecules, and immune-related pathways. Notably, FTH1 showed a positive association with macrophage infiltrations, its expression was particularly noteworthy in malignant cells and macrophages. Inhibiting FTH1-related signaling pathways appeared to be a potential strategy to counteract tumor immunotherapy resistance.

Conclusion
Our comprehensive analyses may offer valuable insights into the role of FTH1 in tumor immunotherapy. The observed correlations pave the way for further functional experiments, fostering an enhanced understanding that could shape future research endeavors.
Mutational analysis of the transmembrane α4-helix of Bacillus thuringiensis mosquito-larvicidal Cry4Aa toxin
Authors: Takahashi Hirokazu , Asakura Mami , Ide Toru , Hayakawa Tohru 
Published: January 2024

AbstractCry4Aa, produced by Bacillus thuringiensis subsp. israelensis, exhibits specific toxicity to larvae of medically important mosquito genera. Cry4Aa functions as a pore-forming toxin, and a helical hairpin (α4-loop-α5) of domain I is believed to be the transmembrane domain that forms toxin pores. Pore formation is considered to be a central mode of Cry4Aa action, but the relationship between pore formation and toxicity is poorly understood. In the present study, we constructed Cry4Aa mutants in which each polar amino acid residues within the transmembrane α4 helix was replaced with glutamic acid. Bioassays using Culex pipiens mosquito larvae and subsequent ion permeability measurements using symmetric KCl solution revealed an apparent correlation between toxicity and toxin pore conductance for most of the Cry4Aa mutants. In contrast, the Cry4Aa mutant H178E was a clear exception, almost losing its toxicity but still exhibiting a moderately high conductivity of about 60% of the wild-type. Furthermore, the conductance of the pore formed by the N190E mutant (about 50% of the wild-type) was close to that of H178E, but the toxicity was significantly higher than that of H178E. Ion selectivity measurements using asymmetric KCl solution revealed a significant decrease in cation selectivity of toxin pores formed by H178E compared to N190E. Our data suggest that the toxicity of Cry4Aa is primarily pore related. The formation of toxin pores that are highly ion-permeable and also highly cation-selective may enhance the influx of cations and water into the target cell, thereby facilitating the eventual death of mosquito larvae.
Pre- and Post-harvest Elicitation with Methyl Jasmonate and Salicylic Acid Followed by Cold Storage Synergistically Improves Red Colour Development and Health-Promoting Compounds in Blood Oranges
Authors: Vithana Mekhala Dinushi Kananke , Singh Zora , Ul Hasan Mahmood 
Published: January 2024

AbstractRed blush is one of the key quality markers of blood orange fruit (Citrus sinensis L. Osbeck). Therefore, the influence of pre- (1, 2, and 3 mM) and postharvest (0.5, 1, and 1.5 mM) methyl jasmonate (MeJA) and salicylic acid (SA) (1, 2, and 3 mM) treatments on redness, colouring pigments, and health-promoting compounds in cold stored ‘Tarocco Ippolito’ blood oranges was investigated. Preharvest application of 3 mM MeJA significantly increased rind citrus colour index (CCI) by 43.3% and colorimetric coordinate a* (redness) by 3.1% and decreased h° (hue angle, 0 = red), L* (lightness), and b* (yellowness) by 13.7%, 12.6%, and 23.4%, respectively. This treatment also enhanced CCI (57.4%), reduced h° (16.5%) and L* (36.4%), and increased total anthocyanins (88%), monomeric anthocyanins (117%), and flavonoids (77%) in the juice. Postharvest dip of 1.5 mM MeJA (5 min) improved CCI of juice (53.6%) and a* (5.5%), reduced h° (15.9%), L* (19.8%), and b* (19.4%), and increased total anthocyanins (66.7%), monomeric anthocyanins (74%), and flavonoids (23.4%) in the juice. Preharvest application of 1 mM SA increased rind CCI (50.8%) and reduced L* (13.6%), b* (16.4%), and h° (29.5%). All preharvest SA treatments significantly increased total phenolics in the juice. Lycopene was increased (61.7%) by 5 min postharvest dip of 3 mM SA. In conclusion, 3 mM preharvest spray application of MeJA four weeks before harvest and postharvest dip of 1.5 mM MeJA (5 min) are effective in improving red colour of rind and juice and health-promoting compounds in blood orange juice.