bluuebunny/crossref_metadata_2025_split huggingface dataset:
A data-driven algorithm to support the clinical decision-making of patient extrication following a road traffic collision
Authors: Vaughan-Huxley Eyston , Griggs Joanne , Mohindru Jasmit , Russell Malcolm , Lyon Richard , Avest Ewoud ter 
Published: December 2023

Abstract
Background
Some patients involved in a road traffic collision (RTC) are physically entrapped and extrication is required to provide critical interventions. This can be performed either in an expedited way, or in a more controlled manner. In this study we aimed to derive a data-driven extrication algorithm intended to be used as a decision-support tool by on scene emergency service providers to decide on the optimal method of patient extrication from the vehicle.

Methods
A retrospective observational study was performed of all trauma patients trapped after an RTC who were attended by a Helicopter Emergency Medical Service (HEMS) in the United Kingdom between March 2013 and December 2021. Variables were identified that were associated with the need for HEMS interventions (as a surrogate for the need for expedited extrication), based on which a practical extrication algorithm was devised.

Results
During the study period 12,931 patients were attended, of which 920 were physically trapped. Patients who scored an “A” on the AVPU score (n = 531) rarely required HEMS interventions (3%). Those who did were characterised by a shorter than average (29 vs. 37 min) 999/112 emergency call to HEMS on-scene arrival interval. A third of all patients responding to voice required HEMS interventions. Absence of a patent airway (OR 6.98 [1.74–28.03] p < .001) and the absence of palpable radial pulses (OR 9.99 [2.48–40.18] p < .001) were independently associated with the need for (one or more) HEMS interventions in this group. Patients only responding to pain and unresponsive patients almost invariably needed HEMS interventions post extrication (90% and 86% respectively). Based on these findings, a practical and easy to remember algorithm “APEX” was derived.

Conclusion
A simple, data-driven algorithm, remembered by the acronym “APEX”, may help emergency service providers on scene to determine the preferred method of extrication for patients who are trapped after a road traffic collision. This has the potential to facilitate earlier recognition of a ‘sick’ critical patient trapped in an RTC, decrease entrapment and extrication time, and may contribute to an improved outcome for these patients.
Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
Authors: Wang Zhuolun , Wang Xinjie , Liu Liangliang , Guo Xiongtian , Zhang Haiyan , Yin Jianbing , Lin Rengui , Shao Yan , Cai Daozhang 
Published: December 2023

Abstract
Purpose
To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA).

Materials and methods
Cartilage samples were collected from OA patients and C57 mice and were stained with Safranin O-Fast Green to determine the severity of OA. Periodic acid Schiff staining was used to characterize the contents of polysaccharides and SA-βGal staining was used to characterize the aging of chondrocytes. Immunohistochemistry and western blotting were used to detect fructose-bisphosphatase1 (FBP1), SOX9, MMP13, P21, and P16 in cartilage or chondrocyte. The mRNA levels of fbp1, mmp13, sox9, colX, and acan were analyzed by qPCR to evaluate the role of FBP1 in chondrocytes.

Results
The level of polysaccharides in cartilage was reduced in OA and the expression of FBP1 was also reduced. We treated the chondrocytes with IL-1β to cause OA in vitro, and then made chondrocytes overexpress FBP1 with plasma. It shows that FBP1 alleviated the degeneration and senescence of chondrocytes in vitro and that it also showed the same effects in vivo experiments. To further understand the mechanism of FBP1, we screened the downstream protein of FBP1 and found that CRB3 was significantly downregulated. And we confirmed that CRB3 suppressed the degeneration and delayed senescence of chondrocytes.

Conclusions
FBP1 promoted the polysaccharide synthesis in cartilage and alleviated the degeneration of cartilage by regulating CRB3, so FBP1 is a potential target in treating OA.
Treatment strategy for lymph node metastasis of hepatocellular carcinoma using an ICG navigation system: a case report
Authors: Furukawa Shunsuke , Ide Takao , Ito Kotaro , Tanaka Tomokazu , Noshiro Hirokazu 
Published: December 2023

Abstract
Background
Since indocyanine green (ICG) accumulates selectively in hepatocellular carcinoma (HCC) cells, it can be used to detect metastatic lesions. Lymph node metastasis of HCC is rarely observed, both simultaneously and metachronously. Therefore, it is sometimes difficult to identify metachronous lymph nodes during salvage surgery because of prior surgery. Herein, we report a case in which lymph node metastasis of HCC was successfully resected using an ICG navigation system.

Case presentation
The patient was a 62-year-old man who had undergone radical liver resection for HCC 8 years ago. During surveillance, contrast-enhanced computed tomography (CT) revealed a mass in the hepatic hilum. Various diagnostic modalities suggested that the patient had a solitary metastatic lymph node of HCC, and extirpation of the tumor was planned. Intraoperative ICG fluorescence imaging allowed surgeons to clearly identify the target lesion. Histopathologically, the tumor was confirmed to be a lymph node metastasis of HCC. The patient’s postoperative course was uneventful, and he remains alive without recurrence 2 years after the second surgery.

Conclusion
Intraoperative navigation surgery by ICG fluorescence imaging was useful for the safe resection of extrahepatic metastasis of HCC in a complicated situation.
Metabolites of Trichoderma harzianum re-balance T-reg/Th-17 cytokine axis in epileptic rats
Authors: Alblihed Mohamed A. 
Published: December 2023

Abstract
Background
Recurrent seizure is synchronous neuronal network hyperexcitation. Even though many anti-epileptic drugs (AEDs) are available, but have several drawbacks, including multiple drug interactions, suboptimal response rates, significant adverse effects, and a narrow therapeutic index. Trichoderma is a biocontrol agent which maintains stress-related gene expression to adapt to unstable environmental conditions. The current study sought to delineate the ameliorative effects of metabolites of Trichoderma harzianum (T. harzianum) culture filtrate (ThCF) by assessing the functions of T regulatory cells and rebalancing oxidative stress.

Methods
Experimental rats were divided into control, epileptic, valproic acid-treated, and T. harzianum cultured filtrate (ThCF). Lipid peroxidation, nitric oxide, and antioxidant defense enzymes were estimated. Moreover, interleukins-6, -10, -17, tumor necrosis factor (TNF-α), and transforming growth factor (TGF-β) were estimated using ELISA kits, in addition to T-reg markers; cytotoxic T-lymphocyte-associated protein 4 (CTLA4), and forkhead box P3 (FOXP3) were estimated by qRT-PCR.

Results
Data revealed that the T. harzianum cultured filtrate (ThCF) retarded the lipid oxidation rate and has antioxidant activities, as well as increased levels of GPx, CAT, and SOD. Moreover, ThCF re-balances T-reg/Th-17 cytokines, restoring the pro/anti-inflammatory cytokines and Treg markers, e.g., FOXP3 and CTLA-4, to their normal level.

Conclusion
Trichoderma harzianum has a potent antioxidant activity with high capacity to scavenge ROS and downregulate all T-reg markers. Therefore, the present data are directed toward the characterization of new active constituents of secondary metabolites of T. harzianum with significant therapeutic functions in several diseases. The promising findings may suggest more clinical and experimental scenarios to reduce AED’s drawbacks and side effects.
Predictors of Perioperative Complications During Leo Baby Stent Treatment for Acutely Ruptured Intracranial Aneurysms: A Retrospective Multicenter Study
Authors: Yan Yazhou , Feng Zhengzhe , Liu Fangqi , Chi Yuxiang , Tang Haishuang , Wu Yina , Wang Jun , Yao Zhiqiang , Huang Qinghai 
Published: December 2023

BACKGROUND AND OBJECTIVES:
Stent-assisted coiling (SAC) of acutely ruptured aneurysms has been controversial. Moreover, for aneurysms originating from small diameter vessels, the SAC presents more challenges. This study aimed to investigate the predictors of perioperative complications after SAC with Leo baby stent of acutely ruptured aneurysms.

METHODS:
We performed a retrospective multicenter analysis of 425 patients with acutely ruptured aneurysms treated with Leo baby. We compared clinical characteristics and outcomes among patients with perioperative complications and those without. Subgroup analysis, including thromboembolic and hemorrhagic complications, was also performed.

RESULTS:
Immediate postoperative angiograms showed Raymond 1 in 357 aneurysms (84.2%), 2 in 53 (12.5%), and 3 in 14 (3.3%). A total of 372 patients (87.5%) were independent (modified Rankin Scale [mRS] score 0-2) at discharge. Perioperative complications occurred in 18 cases (4.2%) harboring 13 cases (3.1%) of thromboembolic complications and 5 cases (1.2%) of hemorrhagic complications. Patients with perioperative complications had a higher rate of unfavorable outcomes at discharge (P = .018), especially with thromboembolic complications (P = .043). Multivariate analysis showed that higher preoperative mRS score (P = .004), irregular shape (P = .017), and larger aneurysms (P = .049) were independent predictors of the overall complications, whereas higher preoperative mRS score (P = .022) was an independent predictor for ischemic complications. The follow-up angiogram was available for 245 patients, and the follow-up angiograms revealed Raymond 1 in 223 aneurysms (91.0%), 2 in 19 (7.8%), and 3 in 3 (1.2%).

CONCLUSION:
Worse clinical condition, irregular shape, and larger aneurysms were independently associated with overall complications, whereas worse clinical condition was viewed as an independent predictor for thromboembolic complications. Attention to these factors is essential for the safe treatment and prognosis of patients with acutely ruptured aneurysms.
STATE OWNED ENTERPRISES: 05 YEARS OF THE NEW CORPORATE GOVERNANCE RULES
Authors: Garcia Ricardo Lupion 
Published: December 2023

ABSTRACTObjective: This article intends to address the new Brazilian regulatory environment created by the SOEs Law (Law No. 13,303, of June 30, 2016) which created new corporate governance rules in state-owned enterprises for the election of directors, officers and fiscal council members, with the purpose of protecting the public companies, the mixed joint-stock corporation and its subsidiaries ("state-owned") against any possible (and unfortunately common) political-partisan interference in the appointment of the members of these top-level management positions in the SOEs. The article will also present cases of progress, setbacks, and the future of this new Brazilian legal norm.Methodology: Review of the bibliography and analysis of judicial and administrative precedents involving the application of new corporate governance rules for state-owned enterprises.Results: It is possible to conclude that the new corporate governance rules were created by Law No. 13,303, of June 30, 2016 with the purpose of protecting the state-owned enterprises (SOEs) against any possible (and unfortunately common) political-partisan interference in the appointment of the members of the top-level management positions in the SOEs.Contributions: From the results found, it is possible to verify: (a) One of the most relevant aspects of the Law No. 13,303, of June 30, 2016 was the creation of academic background, professional experience and professionalization for the top-level management of state-owned enterprises, as usual in the private sector. (b) that the Brazilian Securities and Exchange Commission (CVM) determined the application of the new corporate governance rules for state-owned enterprises; (c) the Judiciary, especially the Federal Supreme Court (STF), can make a relevant contribution if it decides to apply these new rules of governance corporate in order to mitigate political-partisan interference in the appointment of the members of these top-level management positions in the state-owned enterprises (SOEs).
Rhizome
Authors: Mori Lia 
Published: December 2023

Πρόκειται για ένα τυπικό ζευγάρι, με βάση τα ελληνικά κοινωνικά στερεότυπα. Διανύουν το τελευταίο μισό της τρίτης δεκαετίας της ζωής τους. Σε λίγους μήνες πιθανόν να γιορτάσουν - με σχετικώς ισχνή χαρά - την έκτη επέτειο της σχέσης τους. Εκείνος άνεργος - το τελευταίο εξάμηνο - αρχιτέκτονας. Εκείνη δικηγόρος, δουλεύει ως γραμματέας σε ένα δικηγορικό γραφείο.
Legal Aspects of the Functioning of a Limited Liability Company as a Social Enterprise in Polish Law
Authors: Sikorska-Lewandowska Aleksandra 
Published: December 2023

The legal form of a limited liability company is the most popular among all commercial companies in Poland. The vast majority of these companies conduct business activities for profit. However, there are a number of companies that are preoccupied with non-economic activities, pursue pro-social goals, and define themselves as non-profit companies or social enterprises.
The article presents a historical outline and legal basis for the conducting of non-profit activities by limited liability companies in Poland. The subject of the research will be the legal conditions for the obtaining of the status of a social economy entity by a limited liability company and the conditions for the obtaining of the status of a social enterprise, in connection with the entry into force of the Act of August 5, 2022 on the social economy. The possibility of conducting business activity by these entities will also be analysed.
Implementasi blended learning di Sekolah Dasar Maria Regina School Semarang
Authors: Yunhang Lai , Hidayati Dian 
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsikan implementasi model pembelajaran blended learning. Sumber data yang digunakan adalah primer dan sekunder. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Data kemudian dianalisis menggunakan teknik analisis kualitatif meliputi reduksi, penyajian dan penarikan kesimpulan. Hasil penelitian menunjukkan implementasi model pembelajaran blended learning berjalan dengan baik mulai dari perencanaan, pelaksanaan dan penilaian. Faktor Keberhasilan Impelementasi Pembelajaran Blended Learning ialah kemampuan SDM dalam menggunakan metode pembelajaran berbasis online, guru memperbolehkan siswa memperdalam pemahaman materi melalui berbagai media, guru menyiapkan waktu diluar jam kerja untuk menjawab pertanyaan siswa, adanya pengurangan jam mengajar, adanya dukungan penuh dari pengawas sekolah, kepala sekolah dan orangtua siswa. Salah satu kendala guru dalam memberikan pembelajaran ialah ketika guru matematika hendak menyampaikan beberapa macam model untuk menyelesaikan suatu soal, sarana prasarana belum memadai.
Ahmad Dahlan Abad 21: Menggagas Pembaharuan Pendidikan Abad ke-2 Muhammadiyah
Authors: Suyatno Suyatno 
Published: December 2023

Artikel ini diawali dengan sebuah pertanyaan penting, andaikan Ahmad Dahlan hidup hari ini, gagasan pembaharuan pendidikan apa yang akan dilakukan. Pembaharuan pendidikan yang dilakukan oleh Ahmad Dahlan sudah berusia lebih dari satu abad. Tantangan yang dihadapi oleh umat Islam juga berubah. Oleh karena itu, gagasan pembaharuan pendidikan Ahmad Dahlan juga harus senantiasa diperbaharui. Artikel ini bertujuan untuk menjawab dua pertanyaan sebagai berikut: Pertama, tantangan apa saja yang dihadapi oleh pendidikan abad ke-2 Muhammadiyah? Kedua, bagaimanakah gagasan pembaharuan pendidikan abad ke-2 Muhammadiyah? Berdasarkan analisis data terhadap sumber yang dikumpulkan, hasil penelitian menunjukkan bahwa pendidikan abad ke-2 Muhammadiyah memiliki tantangan yang tidak sepenuhnya sama, dan juga tidak sepenuhnya berbeda, dengan tantangan yang dihadapi oleh Ahmad Dahlan semasa hidupnya. Keterbelakangan umat Islam dalam berbagai bidang, problem dikotomi pendidikan Islam, dan pengaruh budaya Barat merupakan tantangan yang serupa yang dihadapi oleh Ahmad Dahlan maupun pendidikan abad ke-2 Muhammadiyah. Sementara itu, perkembangan teknologi informasi, globalisasi, internasionalisasi, dan segenap isu-isu kemanusiaan global merupakan tantangan yang dihadapi oleh pendidikan abad ke-2 Muhammadiyah. Untuk menghadapi berbagai tantangan tersebut diperlukan gagasan-gagasan pembaharuan. Kontekstualisasi lima karakteristik Risalah Islam Berkemajuan, adaptasi epistemologi bayani-burhani-irfani, responsif terhadap perkembangan teknologi informasi, diversifikasi sekolah Muhammadiyah, best future practices, dan internasionalisasi merupakan gagasan-gagasan penting yang diperlukan dalam upaya pembaharuan pendidikan abad ke-2 Muhammadiyah.
The impact of rotational models on workforce stability in UK clinical settings
Authors: Whaley Viki , Hay Jonathan , Knight Kate H , Rooney Cath 
Published: December 2023

Background/Aims To ensure that the NHS workforce remains engaged and productive, rather than leaving the profession, underlying factors that cause attrition must be addressed, and strategies implemented to strengthen retention rates and workforce sustainability. This study aimed to assess the impact of models that allow staff to rotate through different roles and organisations on workforce stability. Methods Project leads employed by organisations within NHS Cheshire and Merseyside integrated care system who had conducted a rotational model were recruited via purposive and snowball sampling. A total of 11 project leads took part in semi-structured interviews about their experiences of the rotational models. Results were analysed using thematic analysis. Results Respondents identified considerable benefits of the rotational models, both for staff and their organisations. Rotational pathways enhanced the transferability of the workforce, with staff developing the knowledge and skills to work across boundaries. Conclusions The broader implementation of rotational models could help to mitigate the recruitment and retention challenges that healthcare organisations such as the NHS are currently experiencing.
Virtual Reality and 3D Simulation in the Treatment of Pediatric Patients with Central Nervous System Tumors
Authors: Mastronuzzi Angela , Baldo Giada Del , Carai Andrea 
Published: December 2023

Pediatric central nervous system tumors are the primary solid malignancies in children and remain a leading cause of mortality in infancy. Advances in pediatric neuro-oncology, driven by molecular oncology research, emphasize the critical need for high-quality pathological tissue to support advanced molecular investigations. However, the vast heterogeneity of these tumors requires precise discrimination of collection sites, aligning with preoperative imaging data. Surgical resection, a pivotal step in diagnosis and treatment, could result in potential morbidities influencing children's neurological status. This, in turn, affects the feasibility of subsequent oncological treatments, influencing overall prognosis and quality of life. To address these challenges, technological tools enhance neurosurgeon orientation in pre-surgical planning and resection. While stereotactic navigation systems reduce morbidity, limitations persist in providing only two-dimensional anatomical information. Recent developments in 3D surgical simulation and virtual reality revolutionize procedural planning, offering real-time integration with intraoperative navigation systems. Beyond surgery, virtual reality has potential in case discussions, preoperative planning, and operative guidance, aiming to improve care and patient outcomes. The virtual reality experience, coupled with detailed anatomical visualization, facilitates meticulous surgical strategy planning for minimal invasiveness. Despite expanding literature on virtual reality applications in neurosurgery, pediatric neurosurgical oncology experiences remain limited. Scientific evaluation of simulation systems' impact on techniques and outcomes, combined with advances in neuroimaging, offers promise for adapting surgical approaches based on neoplastic brain lesion behavior.
In conclusion, incorporating 3D surgical simulation and virtual reality technologies in pediatric neurosurgical oncology holds substantial benefits, offering improved procedural planning, enhanced precision, and patient-specific adaptation. Despite limited reported experiences, the compelling advantages underscore the need for further exploration and consideration in the evolving landscape of pediatric neuro-oncology.
Synthesis of findings from the literature and a qualitative research study on the impacts of gender, disability, and ethnicity in Neglected Tropical Diseases programs
Authors: Arney Jennifer K. , Headland Maureen K. , Bertone Andrea M. , Meite Aboulaye , Ettiegne-Traore Virginie , Asemanyi-Mensah Kofi , Dede Teiko Dzathor Irene , Kargbo-Labour Ibrahim , Jalloh Umu , Houck Patricia , Stukel Diana 
Published: December 2023

Introduction
Act to End NTDs | West, a USAID-funded program that supports national governments to eliminate or control five neglected tropical diseases (NTDs) in West Africa including trachoma, lymphatic filariasis (LF), onchocerciasis, schistosomiasis and soil-transmitted helminthiasis, conducted a gender and social inclusion analysis to determine how NTDs differentially impact various populations and how gender and social norms impact NTD programs to inform future programming.

Methods
The study used a mixed methods approach including a literature review; primary qualitative data collection; and monitoring data in Côte d’Ivoire, Sierra Leone, and Ghana.

Results
Women and girls face additional health risks from many NTDs compared to men and boys. In addition to differential health burden, the social and economic impacts of NTD-related disability or infertility can be particularly dire for women and girls.
Men were somewhat less likely to participate in mass drug administration (MDAs) due to: lack of information about campaigns, lack of access due to work, and higher levels of mistrust of the government and concerns about side effects of the medicines. Pregnant and breastfeeding women were sometimes excluded by community drug distributors (CDDs) from certain types of MDAs for which they are eligible.
Training participation rates for CDDs and supervisors were nearly universally higher for men than women, even though feedback on the effectiveness of female CDDs was overwhelmingly positive, and female CDDs often have more access to other women in conservative households. The role of a CDD can lead to career and social opportunities for women. However, challenges faced by CDDs were seen as a greater barrier for women, including transportation, safety, household responsibilities, lower education levels, and low or lack of wages.

Discussion
Programs to address NTDs can promote equity and improve programming by increasing women’s participation as CDDs and providing financial compensation. Additionally, programs should prioritize inclusive training for CDDs, and inclusive messaging about MDA for communities.