bluuebunny/crossref_metadata_2025_split huggingface dataset:
Position sociale et statut féminin dans les activités quotidiennes
Authors: Roy Caroline , Lemel Yannick 
Published: December 2023

Résumé Résumé : L'étude des positions relatives des femmes et des hommes dans les développées s'appuie généralement sur leur degré de participation à la sphère et le type d'emploi qu'ils occupent. Cette façon de faire accorde au critère de professionnelle une importance qui paraît exagérée. De manière continue depuis trente ans, sans doute de manière analogue a long terme, le temps globalement consacré au professionnel a plutôt tendance à diminuer. On propose ici une méthodologie plus permettant de mieux tenir compte des différentes activités dans lesquelles les gens s'engager. La méthode sera illustrée à l'aide de données françaises issues d'une enquête les emplois du temps des adultes. On essaiera de tester l'hypothèse que l'ensemble des de la vie sociale peuvent simultanément et parallèlement se hiérarchiser. Si on admet, en effet, que le temps passé à une activité est d'autant plus grand que l'activité est plus prestigieuse t individu pratiquant, par lui-même, plus prestigieux, on voit qu'un tableau des temps par activité et par type de pratiquants doit présenter une structure particulière.
L'inégalité devant la culture écrite scolaire : le cas de l' «expression écrite» à l'école primaire
Authors: Lahire Bernard 
Published: December 2023

Résumé L «expression écrite» opère à l'école primaire des différences entre élèves d'origines sociales différentes et contribue à la production des inégalités scolaires. Quel rapport au langage cette pratique scolaire de l'écrit implique-t -elle et construit-elle ? Quelles sont les catégories de jugement scolaire des textes ? Comment décrire et expliquer sociologiquement les performances textuelles «heureuses» et «malheureuses» ? Voilà les questions auxquelles contribue à répondre cet article à partir notamment d'une analyse des productions écrites d'élèves scolarisés en CM1 et en CM2 et issus de milieux sociaux contrastés.
Mise en oeuvre du RMI, évolution des qualifications et modèle professionnel des travailleurs sociaux
Authors: Ion Jacques 
Published: December 2023

Résumé RÉSUMÉ : L'article se propose d'étudier les effets de la mise en place du RMI dans le champ professionnel du travail social. Il y relève le faible investissement des assistantes sociales, l'entrée concomitante de nouveaux professionnels et l' extension de la division du travail. Plus particulièrement, il tente ď analyser comment fonctionne le modèle professionnel dans ces processus de disqualification relative de métiers qui se sont structurés dans les années de croissance et qui doivent évoluer aujourd' hui dans un contexte radicalement transformé.
La Seine amont, espace résiduel ou "secteur stratégique" du schéma directeur d'Ile-de-France ?
Authors: Beckouche Pierre 
Published: December 2023

Résumé RÉSUMÉ : La "Seine Amont" désigne, dans le nouveau Schéma Directeur d'Ile-de-France, une douzaine de communes de la banlieue populaire de Paris. En dépit de son rôle en matière de logistique, c'est un secteur résiduel sur le plan économique. Les activités de haut niveau continuent de s'implanter dans la banlieue Ouest. L'ambition défaire de la Seine Amont un des "secteurs stratégiques" de l'agglomération se heurte à deux difficultés : les communes ont du mal à mettre sur pied un projet commun, mais répugnent à en laisser le soin à l'Etat ; le renchérissement des prix fonciers menace la poursuite de la construction de logements sociaux à proximité immédiate de Paris.
Which histories to write ? What stories to tell !/[Quelles histoires ?]
Authors: Moscovici Serge 
Published: December 2023

Résumé [Quelles histoires?] : La psychologie sociale possède un caractère anomique dans son champ de savoir tenant à sa position intermédiaire entre sociologie et psychologie et à sa progressive subordination à cette dernière ; il s'ensuit un développement fragmenté et discontinu. En outre, sa position positiviste la détourne d'un intérêt majeur pour les pionniers et broie sa mémoire et sa tradition. En Europe, l'évolution de la discipline est déterminée par un «pacte colonial» avec les États-Unis qui implique un manque de considération et une indifférence pour les travaux poursuivis ailleurs. L'auteur s'interroge sur le bien-fondé de l'intérêt pour, et des recherches sur, l'histoire. Il lui semble plus pertinent de changer la psychologie sociale et de la remettre en communication avec son objet et son passé, par des pratiques et des concepts scientifiques différents. Pour ce faire, une démarche historique peut être utile, ce qui suppose un discernement critique que l'auteur, par analogie culinaire, appelle l'usage gourmet (gastronomique) de l'histoire et s'oppose à deux autres modalités de l'histoire — usage exotique (relevant de la diversité mais non d'une cohérence culturelle) et usage gourmand (consistant à fouiller les archives).
Téléphone, communication et sociabilité: des pratiques résidentielles différenciées
Authors: Rowe Frantz , Claisse Gérard 
Published: December 2023

Résumé À l'heure du développement des nouvelles technologies et services de télécommunications grand public, s' intéresser au téléphone plus que centenaire pourrait paraître relever de l archaïsme, de l'histoire ou du tourisme intellectuel. Et pourtant, nous connaissons finalement peu de choses de l'usage domestique du téléphone. Qui téléphone ? Avec quels correspondants ? Pour quels motifs ? Par delà la diversité des communications, est-il possible d'identifier des pratiques téléphoniques différenciées ? Telles sont les principales questions auxquelles cette contribution s'efforce de répondre, sur la base de l'analyse des résultats d'une enquête quantitative. Les effets de la sociabilité et des réseaux de relations sur la consommation et les usages sont également analysés. Au-delà, l'étude des pratiques téléphoniques, objet de cette recherche, se révèle être un excellent outil, tout à la fois heuristique et déformant, pour l'analyse des sociétés contemporaines.
Les États-Unis et le Kosovo. Les risques d'un leadership à bon marché
Authors: Mélandri Pierre 
Published: December 2023

Résumé Face à la crise du Kosovo, la diplomatie américaine est longtemps apparue hésitante et embarrassée. Une opinion hostile depuis le Vietnam à tout engagement dans une guerre où les intérêts vitaux des États-Unis ne paraissaient pas en danger ; un président bientôt prisonnier de l'affaire Lewinski et obnubilé par son combat avec les républicains ; les réticences des nations européennes à comprendre l'impasse à laquelle menait la voie diplomatique ; l'hostilité de la Russie à toute intervention contre l'allié serbe : chacun de ses facteurs a longtemps contribué à maintenir l'isolement de Madeleine Albright, très tôt convaincue de la nécessité d'une intervention militaire. Sur le terrain, cet attentisme a permis la montée en puissance de l'UCK et, surtout, la mise en œuvre des massacres d'Albanais ethniques par les Serbes. Devenue inévitable, la guerre aérienne a mis en évidence les incertitudes de la stratégie alliée. En dépit du succès final, le bilan que l'on peut tirer de la guerre du Kosovo est donc mêlé. Certes, cette guerre a confirmé le leadership des États-Unis sur le monde, mais elle a montré les risques que faisaient courir à la puissance américaine sa difficulté à mettre en œuvre une diplomatie adaptée à la conjoncture de l'après-guerre froide.
Magistrature et « crise de la répression » à la veille de la grande guerre (1911-1912)
Authors: Kalifa Dominique 
Published: December 2023

Résumé Procureur général près la cour d'appel de Lyon, Guillaume Loubat lança en 1911 une offensive à la fois doctrinale et administrative contre ce qu'il considérait être l'insupportable laxisme des tribunaux et des magistrats. Connu sous le nom de « crise de la répression », cet épisode permet de cerner au plus près, en ce début de 20e siècle, le programme des tenants du « tout répressif ». Mais il introduit aussi au cœur d'une crise institutionnelle moderne et livre, à travers une vaste enquête nationale, les conceptions de la haute magistrature en matière de répression, de pénalité et de « sécurité publique ».
Genetic associations of human leukocyte antigen alleles in cutaneous delayed drug hypersensitivity reactions: An updated review
Authors: Chen Chun-Bing , Lee Chih-Chun , Wang Chuang-Wei , Hung Wei-Kai , Chung Wen-Hung 
Published: December 2023

Abstract
Cutaneous delayed drug hypersensitivity reactions (DHRs) are common iatrogenic events with potentially life-threatening consequences. Delayed DHRs encompass diverse phenotypes and can be classified by their distinct T-cell responses to drug antigens. Interaction between the immune receptors, human leukocyte antigen (HLA) and T-cell receptor (TCR), and the complementary antigenic peptide is required for the development of delayed DHRs. These idiosyncratic interactions can be elicited by the formation of antigenic drug-protein adducts (hapten hypothesis) or from direct interactions of drugs with the immune receptors (pharmacological interaction of drugs with immune receptors concept, altered peptide repertoire model, and altered TCR model). In addition, viral infections may play a role by providing co-stimulatory signals or enhancing TCR/HLA expression on T-cells. The associations of HLA allele polymorphisms and DHRs are phenotype and ethnicityspecific. The discovery of genetic polymorphisms associated with DHRs has provided a strategy to prevent and diagnose potentially life-threatening reactions. Recently, advances in next-generation sequencing technologies, such as the incorporation of whole-exome or whole-genome sequencing, enabled the comprehensive detection of susceptibility loci. Several HLA associations have shown clinical utility and cost-effectiveness, such as HLA-B*15:02 (carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in Han Chinese), HLA-B*58:01 (allopurinol-induced severe cutaneous adverse reactions in Han Chinese), HLA-B*57:01 (abacavir hypersensitivity reactions in Caucasians), and HLA-B*13:01 (dapsone-induced drug reaction with eosinophilia and systemic symptoms in Han Chinese). Herein, we summarize the current knowledge of the pathogenesis, antigen presentation models, and HLA associations of cutaneous delayed DHRs.
Efficacy and safety of cysteamine-isobionicamide complex in postinflammatory hyperpigmentation: A 16-week, randomized, double-blinded, vehicle-controlled trial
Authors: Liu Rosalie Tzu-Li , Tsai Tsung-Fu , Lai Yi-Jing , Ng Chau Yee 
Published: December 2023

Abstract

Background:
Postinflammatory hyperpigmentation (PIH) is a prevalent acquired hyperpigmentation disorder with significant psychosocial implications. Cysteamine has demonstrated notable efficacy and safety in treating hyperpigmentation disorders. This study conducted a double-blinded, randomized clinical trial to evaluate the efficacy and safety of the cysteamine-isobionicamide complex in managing PIH.

Objectives:
The objective was to assess the cysteamine-isobionicamide complex’s efficacy for PIH treatment through comprehensive clinical and imaging evaluations.

Methods:
Forty patients with PIH were recruited at a tertiary medical center from 2021 to 2022 and randomized into the cysteamine-isobionicamide complex treatment group and placebo-vehicle control group. Dermatological assessments, investigator and patient global assessments, and quality of life scores were collected at baseline, week 4, week 8, and week 16. Quantitative evaluation of skin type and lesion pigmentation was performed with the Mexameter®, VISIA skin analyzer, and cellular resolution optical coherence tomography (OCT).

Results:
At week 8, the cysteamine-isobionicamide complex treatment group exhibited marked advancement in dermatological assessments, melasma area and severity index (MASI), total postacne hyperpigmentation index, and life quality score compared with the placebo-vehicle control group. Furthermore, melanin index and erythema index scores from Mexameter® and VISIA analysis exhibited significant improvement for brown spots at week 16. Cellular resolution OCT imaging revealed decreased melanosome capping and fewer hyperreflective melanophages.

Conclusion:
This study demonstrated the clinical effectiveness and safety of the cysteamine-isobionicamide complex through comprehensive dermatological assessments, imaging techniques, and patient-reported outcomes. The complex emerges as a promising therapeutic option for PIH, offering potential relief to individuals affected by this hyperpigmentation disorder.
Comparison of dimensional stability and pH of experimental root canal sealer with commercially available root canal sealers: An in vitro study
Authors: Shetty Chitharanjan , Shetty Aditya , Hegde Mithra N. 
Published: December 2023

ABSTRACT

Aim:
The goal of the study is to evaluate and compare the pH and dimensional stability of the experimental root sealer to those of existing root sealers commonly used in endodontic therapy.

Methods:
The study samples were produced using commercially available sealers as well as experimental sealers containing nanoparticles. The pH was measured using a digital pH meter (accuracy of 0.01). Before each pH measurement, the pH meter’s accuracy was calibrated with a solution. Once the relevant dimension samples were generated, the dimensional stability of the materials was evaluated. L 30 - L/L × 100 was the formula used to calculate the percentage of dimensional change.

Results:
The Apexit Plus demonstrated a 1.33% expansion compared to the experimental sealer’s 0.43%. The contraction was 0.37% for AH Plus. The mean pH of the experimental root canal sealer utilized at various periods of immediate, 24 h and 1 week after is 9.51, 8.48, and 8.17. The mean pH of the AH Plus root canal sealer immediately, 24 h and 1 week was 8.30, 7.70, and 6.80, respectively.

Conclusion:
Within the constraints of the studies, the experimental sealer had stronger pH and dimensional stability than commercially available sealers. In vivo studies can be performed to reassess the qualities.
Characteristics of endodontic clinical trials registered in clinicalTrials.gov between 2000 and 2022
Authors: Praveen Gadde , Akkaloori Anitha , Indukuri Sai Lakshmi Durga , Divvi Anusha , Shammas Mohammed , Kumar B. Jambukeshwar , Kumar Konakanchi Bharath , Medicharla Uma Devi 
Published: December 2023

ABSTRACT

Aim:
This study aims to examine the characteristics of endodontic clinical trials registered in the ClinicalTrials.gov database.

Methods:
The ClinicalTrials.gov website was searched for endodontic clinical trials that were registered between 2000 and 2022. The search term used was “endodontics.” As a result of the search strategy, 613 trials were identified. Out of which, 500 clinical trials met our inclusion criteria. For each clinical trial, information was extracted including the year of registration, location of the trial, type of trial, study design (allocation, intervention model, and masking) estimated enrollment, participants’ age, health condition/problems studied, intervention/treatment, the status of the trial, study results, phase of the trial, and source of funding. Fisher’s exact test was applied to identify the characteristics of clinical trials associated with funding.

Results:
The number of registered clinical trials gradually increased from 2000 to 2022. Out of 500 clinical trials, 456 were interventional, and 44 were observational. Only 18 clinical trials had secured funding. The majority of interventional trials (90.8%) are randomized, and the most common interventional model was parallel assignment (88.4%). It was observed that irreversible pulpitis was the most common condition studied (32.2%). Nonsurgical endodontic therapy was the most common intervention used in the trials (42.2%).

Conclusion:
The study provided an overview of endodontic clinical trials that were registered in the ClinicalTrials.gov. The findings showed that registered endodontic clinical trials have increased rapidly since 2000. The vast majority of trials took place in Africa. The majority of endodontic clinical trials followed rigorous methods in terms of allocation, intervention model, and masking. However, only a small portion of trials had secured funding. The findings also indicate the need for trial results to be made publicly available to enhance evidence-based practice in endodontics.
Anesthetic efficacy of articaine versus lignocaine as supplementary buccal infiltration after failed inferior alveolar nerve block – A systematic review of randomized clinical trials
Authors: Goutham Pradeeba Anandi Jeya , Rajakumaran Arasappan , Kuzhanchinathan Manigandan , Balaji Lakshmi 
Published: December 2023

ABSTRACT

Aim:
The aim of this study was to compare the anesthetic efficacy of 4% articaine and 2% lidocaine as supplementary buccal infiltration after failed inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis.

Methods:
MESH terms and specific keywords were used to search Scopus, EBSCOhost, Cochrane Library, and PubMed. Randomized clinical trials were among the included articles that compared the anesthetic efficacy of 4% articaine or 2% lignocaine as supplementary buccal infiltration following a failed IANB in patients with chronic irreversible pulpitis.

Results:
Five of the 871 studies that were reviewed were given full-text reading considerations, and three studies were subjected to qualitative analysis after meeting the inclusion and exclusion criteria. In 234 patients altogether, patients anesthetized with 4% articaine buccal infiltration had a success rate of 61%–83.3% in the 118 patients in the 4% articaine BI group and 116 patients in the 2% lidocaine BI group.

Conclusion:
Supplemental buccal infiltration with 4% articaine in permanent mandibular molars was associated with greater anesthetic efficacy than the 2% lignocaine in patients with symptomatic irreversible pulpitis after unsuccessful IANB.
History and Evolution of Capillary Glucose Monitoring
Authors: Kesavadev Jothydev , Das Ashok Kumar , Manojan K. K. , Muruganathan A. , Jagadeesha Aravinda , Shenoy Mohan T. , Sreelakshmi R. , Basanth Anjana , Jothydev Krishnadev , Krishnan Gopika 
Published: December 2023

Abstract
Monitoring of blood glucose levels is an inevitable part of diabetes management. The last decade was marked by path-breaking and transformational changes in diabetes technologies that ushered in the introduction of a wide spectrum of glucose monitoring devices that are more reliable and user-friendly. This review describes the evolution of capillary glucose monitoring from simple urine sugar screening tests to reagent strip systems and to sophisticated glucose monitors over the past four decades since the introduction of the first glucose meter in 1970.
Metastatic alveolar soft part sarcoma of the kidney in a young female
Authors: Kumar Shritosh , Nayak Brusabhanu , Bharati Vandna , Kaushal Seema , Sharma Mehar Chand 
Published: December 2023

ABSTRACT
A 19-year-old female presented with left flank discomfort and swelling. Imaging revealed a large mass arising from the left kidney, and radical nephrectomy confirmed the diagnosis of alveolar soft part sarcoma (ASPS) based on histopathological and ultrastructural examination. Postoperatively, positron emission tomography–computerized tomography showed lung metastasis and renal bed recurrence. Sunitinib was initiated for metastatic ASPS. This case underscores challenges in diagnosing and managing ASPS, highlighting the role of tyrosine kinase inhibitors. Multidisciplinary care and vigilant follow-up are crucial for rare tumors such as ASPS.
Malnutrition: The Hidden Danger in Bariatric Surgery
Authors: Cooke Spencer Waters , Miller Zachary Colton , Kang Brian Kyungmin , Ashley Lucas Wade , Pories Walter J. 
Published: December 2023

Abstract
Malnutrition is a hidden, subtle, and dangerous challenge in bariatric surgery. The severely obese, almost always burdened by other comorbidities, and mixed dietary histories are also, all too often, malnourished, especially in micronutrients, a setting that leads to complications not only in the perioperative period but also during the years after the surgery. The objective of this review was to offer a case report, review the assessment of obesity and malnutrition, note approaches to prevention and treatment, and suggest the founding of metabolic centers to facilitate interdisciplinary approaches to this serious and common problem.
Efficacy and safety of a pyrotinib-based regimen in non-small cell lung cancer patients harboring HER2 alterations: A real-world retrospective study
Authors: Wang Xiangling , Wang Jian , Chu Yunxia , Hao Jing 
Published: December 2023

Background:
Pyrotinib, a novel irreversible pan-HER tyrosine kinase inhibitor, has been approved for the treatment of HER2-positive metastatic breast cancer in China. The aim of this study was to evaluate the efficacy and safety of pyrotinib in advanced nonsmall cell lung cancer (NSCLC) patients with HER2 alterations in real-world practice.

Materials and Methods:
A retrospective analysis of advanced NSCLC with HER2 mutations or amplifications who received pyrotinib-based treatment at the Qilu Hospital in Shandong University was performed. The primary end points were objective response rate and safety. The secondary end points were progression-free survival, disease control rate, and overall survival.

Results:
Twenty three eligible patients from a single center were enrolled between June 2019 and March 2023; among them, 21 had HER2 mutation and two harbored HER2 amplification. Evaluation of the efficacy in 21 patients revealed an objective response rate of 28.6% (6/21; 95% confidence interval [CI]: 7.5%-49.6%) and disease control rate of 85.7% (18/21). The median progression-free survival and overall survival were 7.7 months (95% CI: 6.07-9.33) and 20.8 months (95% CI: 8.42-33.18), respectively. The most common adverse events (AEs) included diarrhea (n = 14, 60.9%), nausea (n = 5, 21.7%), and liver dysfunction (n = 5, 21.7%). Seven patients (7/23, 30.4%) had grade 3-4 AE; no grade 5 AE was observed. Furthermore, one patient (1/23, 4.3%) experienced dose withdrawal and two (2/23, 8.7%) presented with dose reduction symptoms.

Conclusion:
Pyrotinib-based therapy showed promising antitumor activity and acceptable safety in advanced NSCLC patients with HER2 alterations.
An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway
Authors: Cao Yuanyuan , Wo Mingyi , Xu Chan , Fei Xianming , Jin Juan , Shan Zhiming 
Published: December 2023

Objective:
This study aimed to evaluate the impact of an adenosine monophosphate-activated protein kinase (AMPK) agonist, metformin (MET), on the antitumor effects of macrophages and to determine the underlying mechanism involved in the process.

Materials and Methods:
M0 macrophages were derived from phorbol-12-myristate-13-acetate-stimulated THP-1 cells.

Results:
The levels of tumor necrosis factor-alpha (TNF-α) and human leukocyte antigen-DR (HLA-DR) were decreased in macrophages incubated with HCT116 cells, whereas those of arginase-1 (Arg-1), CD163, and CD206 were elevated; these effects were reversed by MET. The transfection of small interfering (si) RNA abrogated the influence of MET on the expression of the M1/M2 macrophage biomarkers. MET significantly suppressed the proliferation and migration abilities of HCT116 cells incubated with M0 macrophages; these actions were reversed by siRNA transfection against AMPK. The hypoxia-inducible factor 1-alpha (HIF-1α), phosphorylated protein kinase B (p-AKT), and phosphorylated mammalian target of rapamycin (p-mTOR) levels were reduced by the introduction of MET and promoted by siRNA transfection against AMPK. In addition, the levels of HIF-1α, p-AKT, and p-mTOR suppressed by MET were markedly increased following the transfection of siRNA against AMPK.

Conclusion:
These findings indicate that MET can repress the progression of colorectal cancer by transforming tumor-associated macrophages to the M1phenotype via inhibition of the HIF-1α and mTOR signaling pathways.