bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive benchmarking for evaluating TCR embeddings in modeling TCR-epitope interactions
Authors: Feng Xikang , Huo Miaozhe , Li He , Yang Yongze , Jiang Yuepeng , He Liang , Cheng Li Shuai 
Published: January 2025

Abstract
The complexity of T cell receptor (TCR) sequences, particularly within the complementarity-determining region 3 (CDR3), requires efficient embedding methods for applying machine learning to immunology. While various TCR CDR3 embedding strategies have been proposed, the absence of their systematic evaluations created perplexity in the community. Here, we extracted CDR3 embedding models from 19 existing methods and benchmarked these models with four curated datasets by accessing their impact on the performance of TCR downstream tasks, including TCR-epitope binding affinity prediction, epitope-specific TCR identification, TCR clustering, and visualization analysis. We assessed these models utilizing eight downstream classifiers and five downstream clustering methods, with the performance measured by a diverse range of metrics for precision, robustness, and usability. Overall, handcrafted embeddings outperformed data-driven ones in modeling TCR-epitope interactions. To further refine our comparative findings, we developed an all-in-one TCR CDR3 embedding package comprising all evaluated embedding models. This package will assist users in easily selecting suitable embedding models for their data.
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization
Authors: Liu Shunying , Li Lingfei , Liang Yi , Tan Yang , Wang Xiaoyu , Feng Yanhai , Chen Nian , Lei Xia 
Published: January 2025

Abstract
Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed. A large-scale meta-analysis of psoriasis genome-wide association studies (GWAS) totaling 20 105 cases and 842 975 controls was conducted. Based on the GWAS results, Mendelian randomization (MR) analyses were then performed on three cis-protein quantitative trait loci (pQTL) data in blood. Furthermore, druggability verification and mouse knock-out models were utilized to explore the clinical value of screened proteins. We identified 42 genome-wide significant psoriasis risk variants (P &lt; 5 × 10−8), of which 33 were previously unreported. MR analyses unveiled 19 unique circulating proteins that were associated with psoriasis, among which only AIF1, FCGR3A, NEU1, HSPA1A, TNXB, and ABO were the potential proteins that interacted with psoriasis risk after being analyzed with high evidence of colocalization (PP.H4 &gt; 0.9). In addition, AIF1, FCGR3A, and HSPA1A have been finally determined to be feasible therapeutic targets for psoriasis after being confirmed by druggability verification and specific mouse knock-out models. This large-scale GWAS meta-analysis identified 33 new variants for psoriasis. This study announced that AIF1, FCGR3, and HSPA1A were the unexplored but material variants of psoriasis, thus providing novel and valuable targets for psoriasis treatment and broadening new orientation of drug development for psoriasis.
Criminology, Conspiracy Theories and Theorizing Conspiracy
Authors: Kindynis Theo 
Published: January 2025

Abstract
This article challenges criminologists to adopt a more critical orientation to conspiracy theories. The first part of the article suggests that a moral panic over conspiracy theories has given rise to a conspiracy theory research agenda that has pathologized and criminalized conspiracy theories. The second part of the article argues that although conspiracies are important sociological and political phenomena, the term ‘conspiracy theory’ functions to stigmatize certain narratives. The article traces the origins of conspiracy denial in the social sciences. The final part of the article argues that criminologists should take conspiracy theories seriously and seek to investigate conspiracies. If popular conspiracy theories about elite wrongdoing are invalid, criminologists should develop better explanations of how and why conspiracies take place, as well as who conspires and to what ends. The article outlines some existing concepts and approaches that criminologists might utilize to this end.
In/visibilities
Authors: George Jain Abhimanyu 
Published: January 2025

Abstract
In Drones and International Law, Rebecca Mignot-Mahdavi describes and explains how drones, war and law interact with and shape each other in the context of counterterrorism. Mignot-Mahdavi’s argument is rich, incisive and provocative. It makes a significant contribution not only to the literature on drones and international law but also to the literature on international law and technology and legal theory. This review essay highlights and problematizes three significant choices (or exclusions) that shape Mignot-Mahdavi’s argument – her conceptualization of technological agency, of legal argumentation and change and of the novelty of the transnational jihadist threat.
Investigation of a static source model for non-seismic tsunamis using waveform inversion: a case study of the 2018 Anak Krakatau event
Authors: Yatimantoro Tatok , Yamanaka Yusuke , Gusman Aditya Riadi , Tanioka Yuichiro , Ratnasari Rinda Nita , Karnawati Dwikorita 
Published: January 2025

SUMMARY
This study investigates the effectiveness of inversion methods using tsunami waveforms to analyse volcanic tsunami sources, which are a type of non-seismic tsunami source. We focused on the 2018 Anak Krakatau tsunami triggered by a volcanic eruption. This study developed a static initial sea surface displacement model based on tsunami waveform inversion with data recorded at tide gauge stations using a Gaussian-shaped sea surface displacement for the unit source. A key characteristic of our model is that all initial velocity components of the tsunami were zero. We tested 12 scenarios for accuracy to determine the most plausible sea surface displacement. The optimal displacement model reasonably reproduced the observed tsunami waveforms. The calculated water volume at the initial sea surface displacement was reasonably consistent with the total collapse volume of the Anak Krakatau eruption by magnitude. These findings suggest that our approach to developing a static source model can effectively apply to non-seismic tsunami events. Although this approach offers simplified tsunami source modelling for tsunami estimation during volcanic eruptions with complex source dynamics, further validation is required for its application to other non-seismic tsunami events.
A political economy analysis of health policymaking in Nigeria: the genesis of the 2014 National Health Act
Authors: Chukwuma Julia Ngozi , Obi Felix Abrahams 
Published: January 2025

Abstract
This article explores the ideologies, interests, and institutions affecting health policymaking in Nigeria, and the role of the private sector therein. It covers the period from the late-1950s, the years leading up to independence, to 2014, when the country enacted its first-ever law to govern its healthcare system. The National Health Act (NHAct) was adopted after a decade of preparation and civil society-driven advocacy, making the objective of universal health coverage (UHC) explicit. However, in its final version, the NHAct earmarked only a small share of public funds for UHC, solidifying the country’s reliance on private healthcare and out-of-pocket payments. To examine the specific set of ideologies, interests, and institutions defining Nigeria’s pathway toward UHC and the contribution of the private sector, we adopted the political economy framework, situating the genesis of the 2014 NHAct within the broader political and economic context of Nigeria’s health system reform process since the 1950s. Drawing on qualitative data collected during interviews and focus groups, we found that the deep entrenchment of private-sector healthcare in Nigeria is the result of a path-dependent process. This implies that Nigeria’s current reliance on the private sector is influenced by historical patterns, competing interests, and institutional practices that have reinforced the role of private actors over time. We identified three major explanatory factors that have shaped health policymaking in Nigeria. First, since the 1980s, the ideology that private healthcare is the solution to an underfunded and underperforming public healthcare system has been reinforced by leading international organizations. Second, private actors in Nigeria have been in a strong position to influence health policymaking since independence. Third, Nigeria’s challenging socio-economic context and the limitations of its federal governance structure have fostered a general level of public distrust in the capacity of the public sector to provide quality healthcare.
Key informants’ views on the benefits, planning and implementation of workplace oral health promotion programme
Authors: Bakri Noor Nazahiah , Thomson W M , Broadbent Jonathan M , Smith Moira B 
Published: January 2025

Abstract
This study aimed to explore key informants’ views on the potential benefits of workplace oral health promotion (WOHP) among the aged care workforce and identified factors associated with the planning and implementation of such activities. The study interviewed members of key organizations associated with the aged care workforce, including oral health and health professionals, government and non-governmental organizations, aged care providers, unions and other worker support organizations in semi-structured interviews. Interviews were audio-recorded, transcribed verbatim and analysed thematically. Fourteen (of 17 invited) key informants participated. Promoting oral health among those working in the aged care sector is perceived to have advantages for staff oral health and psychological and mental well-being, and potentially has a ‘flow-on effect’ on the organization’s productivity, operation and human and financial resources. Six factors that can act as facilitators or barriers to WOHP planning and implementation were identified: (i) organization structure, needs, priorities, and higher management contribution; (ii) resources (funding, facilities, human and time capacity); (iii) collaborators; (iv) individual or target audience; (v) communication; and (vi) sustainability of the programme. The study concluded that WOHP in the aged care sector is possible and likely has benefits for staff and the organizations involved. Consideration should be given to identifying and addressing the factors that influence the development and implementation of WOHP programmes. Good organization, support of management, availability of funding, support from collaborators and consideration of individual needs are needed to have a successful, sustainable WOHP programme that meets the needs of the aged care workforce.
Microgrid cooperative scheduling optimization based on quality of service constraint and deep Q-network algorithm
Authors: Zhou Jie , Lu Rong 
Published: January 2025

Abstract
This paper proposes a quality of service Cloud Workflow Firefly Algorithm (CWFA), which considers dynamic priorities. Whenever the algorithm experiences a new state–action pair, this experience is recorded as part of the training data. Genetic algorithm (GA) is introduced to optimize the initial parameters of deep Q-network (DQN). Through GA, a better initial weight can be found, so as to improve the estimation of Q-value, making the overall workflow scheduling more efficient. The simulation results show that, compared with other methods, CWFA–GA–DQN can effectively improve the efficiency of microgrid cooperative scheduling.
General practice antibiotic prescriptions attributable to respiratory syncytial virus by age and antibiotic class: an ecological analysis of the English population
Authors: Miller Lucy , Beaney Thomas , Hope Russell , Cunningham Mark , Robotham Julie V , Pouwels Koen B , Costelloe Cèire E 
Published: January 2025

Abstract

Background
Respiratory syncytial virus (RSV) may contribute to a substantial volume of antibiotic prescriptions in primary care. However, data on the type of antibiotics prescribed for such infections are only available for children &lt;5 years in the UK. Understanding the contribution of RSV to antibiotic prescribing would facilitate predicting the impact of RSV preventative measures on antibiotic use and resistance. The objective of this study was to estimate the proportion of antibiotic prescriptions in English general practice attributable to RSV by age and antibiotic class.

Methods
Generalized additive models examined associations between weekly counts of general practice antibiotic prescriptions and laboratory-confirmed respiratory infections from 2015 to 2018, adjusting for temperature, practice holidays and remaining seasonal confounders. We used general practice records from the Clinical Practice Research Datalink and microbiology tests for RSV, influenza, rhinovirus, adenovirus, parainfluenza, human metapneumovirus, Mycoplasma pneumoniae and Streptococcus pneumoniae from England’s Second Generation Surveillance System.

Results
An estimated 2.1% of antibiotics were attributable to RSV, equating to an average of 640 000 prescriptions annually. Of these, adults ≥75 years contributed to the greatest volume, with an annual average of 149 078 (95% credible interval: 93 733–206 045). Infants 6–23 months had the highest average annual rate at 6580 prescriptions per 100 000 individuals (95% credible interval: 4522–8651). Most RSV-attributable antibiotic prescriptions were penicillins, macrolides or tetracyclines. Adults ≥65 years had a wider range of antibiotic classes associated with RSV compared with younger age groups.

Conclusions
Interventions to reduce the burden of RSV, particularly in older adults, could complement current strategies to reduce antibiotic use in England.
Comparison of interobserver and Intraobserver reliability of alpha angle measurements using different types of circles for femoroacetabular impingement syndrome
Authors: Aydin Özgür , Hapa Onur , Acar Emre , Celtik Mustafa , Agca Selahattin , Turemis Cihangir , Yarol Raif C , Aydemir Selahaddin 
Published: January 2025

Abstract
The alpha angle is a radiological measurement that has been proposed for the detection of cam morphology in patients suspected of femoroacetabular impingement syndrome (FAIS). After analysing published articles on FAIS, it is apparent that different types of circles are used in the measurement of alpha angles. To determine the interobserver and intraobserver reliability of alpha angle values measured using different types of circles on a 45° Dunn lateral radiograph in patients with symptomatic FAIS. The 45° Dunn lateral radiographs of the operated hips of patients who underwent hip preservation surgery in Dokuz Eylül University Hospital between 2014 and 2017 were evaluated retrospectively. Alpha angles were measured manually with transparent goniometers using three different circle types: thin full circle, thin-dashed circle, and thick full circle, and eye estimation without circle insertion. Measurements were made separately by an orthopaedist and a radiologist. A second measurement was made by the radiologist 1 month later for intraobserver reliability. Interobserver reliability for the thin full circle, thin-dashed circle, thick circle, and eye estimation (ICC = 0.645, 0.525, 0.494, and 0.588, respectively). Intraobserver reliability for the thin, thin-dashed, thick line, and eye estimation (ICC= 0.626, 0.681, 0.681, and 0.462 respectively). Interobserver difference of mean values of alpha angles for thin full, thin-dashed, thick full, and eye estimation were 2.7°, 0.9°, 1.1°, and 2.3°, respectively. Intraobserver differences between measurements were 1.5°, 0.9°, 0°, and 1.6°, respectively. Our study demonstrated that interobserver reliability is highest when measurements are made using a thin full circle.
Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1
Authors: Askari Kasra , Johnson Jennifer L , Shukla Aparna , Meneses-Salas Elsa , Kiosses William B , Yu Juan , Catz Sergio D 
Published: January 2025

Abstract
Regulated sequential exocytosis of neutrophil granules is essential in orchestrating the innate immune response, while uncontrolled secretion causes inflammation. We developed and characterized Nexinhib20, a small-molecule inhibitor that targets azurophilic granule exocytosis in neutrophils by blocking the interaction between the small GTPase Rab27a and its effector JFC1. Its therapeutic potential has been demonstrated in several pre-clinical models of inflammatory disease. Here, using neutrophils from Jfc1-KO mice, we show that JFC1 regulates the mobilization of a small subpopulation of CD11b+ granules. Nexinhib20 inhibits the mobilization of β2-integrins from a subset of CD11b+ granules to the plasma membrane in human and mouse neutrophils. The putative impact of Nexinhib20 on integrin activation is caused by decreased avidity, secondary to its effect on β2-integrin mobilization. CD11b mobilization and integrin activation were unaffected by pharmacological inhibition or activation of Rac1. Using quantitative 3-dimensional enhanced resolution microscopy, we show that neutrophil activation induces the recruitment of JFC1 to CD11b+ granules. Nexinhib20 decreased the localization of JFC1 at CD11b+ granules without affecting the association of Rac1 with CD11b. Nexinhib20 inhibits JFC1 recruitment but not endogenous Rac1 activation in living cells. Using orthogonal analyses of Rac1 activity consisting of a sensitive, time-resolved FRET, Rac1-PAK1-binding assay, and endogenous Rac1-GTP examination, we show that Nexinhib20 does not interfere with Rac1 activation. Instead, we confirmed its molecular mode of action to the inhibition of the Rab27a-JFC1 binding axis. Thus, Nexinhib20 limits β2- integrin mobilization to the cell surface, decreasing avidity, affecting active integrin availability, in a JFC1-dependent but Rac1-independent manner.
Hang in there: Capacity constraints and processes of sustaining collaboration over time
Authors: Seo Danbi 
Published: January 2025

Abstract
Sustaining collaboration over time is vital for its effectiveness and long-term success but presents challenges, especially for actors with capacity constraints. This study introduces “capacity tensions” as a central challenge in collaborative efforts, referring to the strain that arises when the capacity needed for effective engagement exceeds the capacity actors have available. This gap creates competing demands, as actors must balance what they can realistically contribute with what the collaboration needs to remain viable and successful. Focusing on a nonprofit collaboration that, despite ongoing capacity constraints, persisted with notable achievements, this study investigates how actors navigate and manage these tensions to sustain their efforts. By analyzing 165 interviews conducted over 11 rounds, participant observations, and archival documents from 2016 to 2020, this study identifies strategies of internal accommodation and external orientation. These strategies enabled actors to “hang in there” by assembling different contributions; tailoring work process; searching for relevant opportunities; and creating spin-off projects. Examining these strategies across three phases of collaboration over five years, this study proposes a process model that offers insights into sustaining effective collaboration despite capacity tensions. These findings provide valuable guidance for practitioners and scholars striving to build sustainable and resilient collaborations.
Papillary thyroid carcinoma within struma ovarii: a case report and literature review
Authors: Qaradakhy Aras J , Ali Rawa M , Ali Rebaz M , Yasseen Hadeel A , Hussein Shvan M , Abdullah Hiwa O , Hassan Shko H , Ahmed Harun Amanj , Salih Abdulwahid M , Othman Snur , Kakamad Fahmi H 
Published: January 2025

Abstract
Struma ovarii (SO) is a rare ovarian teratoma mostly made of thyroid tissue, with papillary thyroid carcinoma (PTC) being even rarer. This report presents a 50-year-old woman with PTC in SO and a normal thyroid. A left ovarian cyst was detected by ultrasound and confirmed by MRI. Surgery included total abdominal hysterectomy with bilateral salpingo-oophorectomy, revealing focal PTC and no thyroid abnormalities. A review of 10 cases showed a median diagnosis age of 46.5 years, with symptoms like abdominal pain and vaginal bleeding. Routine checkups in perimenopausal women are key for early detection, and thyroid evaluation is important in PTC cases within SO.
Happy birthday dear BNOC, happy birthday to you
Authors: Roberts Peter 
Published: January 2025

Abstract
This year marks what would have been the 50th birthday of the British National Oil Corporation (BNOC), which came into existence through the enactment of the Petroleum and Submarine Pipelines Act 1975. This article considers why BNOC came into being, why BNOC ceased to function after a relatively short period of time, and whether any lessons could be learned from BNOC’s past that could be helpful in shaping future energy regulatory policies.
Session 6: Working with Your Thoughts (Part I)—Coping Self-Statements
Authors: Beck J. Gayle 
Published: January 2025

Abstract
This chapter introduces skills that will help clients to work with negative thoughts, particularly developing and using coping self-statements. Cognitive therapy techniques are designed to address common elements of thinking, such as negative self-talk and distortions in perception, and can help clients to become aware of the underlying assumptions that guide their thinking. Coping self-statements can be useful when clients are facing stressful or challenging situations. Clients can learn to use coping self-statements to challenge the stream of negative self-talk that is common among individuals with PTSD. If time permits, this session can also include practice with progressive muscle relaxation.
Group Cognitive Behavioral Therapy for PTSD
Authors: Beck J. Gayle 
Published: January 2025

Abstract
Group Cognitive Behavioral Therapy (CBT) for PTSD : Client Workbook for Veterans assists clients who are participating in a Group Cognitive Behavior Therapy and is designed to be used with the accompanying Therapist Guide. The Client Workbook provides a concise overview of each chapter, along with information sheets and worksheets to facilitate between session practice. This treatment program integrates best practices derived from group therapy with evidence-based cognitive behavioral approaches to target PTSD and frequently co-occurring conditions ( depression, anger, and social isolation). Tested with both Veteran and non-Veteran populations, Group CBT has been proven to reduce symptoms of PTSD and improve quality of life, overall functioning, and life satisfaction. Essentially, the Client Workbook is designed to track progress and facilitate mastery of specific CBT techniques, to enhance mental well-being.
Session 11: Feeling Down— How to Fight It
Authors: Beck J. Gayle 
Published: January 2025

Abstract
This chapter focuses on how to address feelings of depression and low mood. Depression can become a problem when these feelings become more pronounced or when they last for several weeks. Depression can interfere with people's enjoyment of lifeand acknowledging depression can help begin the fight on days when the mood is really low. This session introduces pleasant activity scheduling, which helps to remedy the imbalance between negative and positive interactions with the world around you. The goal is to increase both the quantity and quality of positive interactions, with the result being an improved mood. A worksheet is included to help clients determine their beginning level of positive interactions to guide pleasant activity scheduling.