bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contratações públicas e competências estaduais em matéria antidiscriminatória: o caso da Lei Norte-rio-grandense nº 11.587/2023
Authors: França Vladimir da Rocha 
Published: February 2025

O objetivo do presente artigo é examinar, à luz da Constituição do Estado do Rio Grande do Norte, o modelo jurídico instituído pela Lei do Estado do Rio Grande do Norte nº 11.587, de 8 de novembro de 2023, que dispõe sobre a reserva de vagas de emprego para travestis e transexuais nas empresas privadas que recebem incentivos fiscais ou tenham convênio com órgãos do Poder Público do Estado do Rio Grande do Norte. Para tanto, adota-se a metodologia preconizada pela Dogmática Jurídica (ou Ciência do Direito em sentido estrito), tendo como base empírica o sistema do Direito Positivo brasileiro.
Requiring an Interpreter Influences Stroke Care and Outcomes for People With Aphasia During Inpatient Rehabilitation
Authors: Mellahn Kathleen , Kilkenny Monique F. , Siyambalapitiya Samantha , Lakhani Ali , Burns Catherine , Purvis Tara , Cadilhac Dominique A. , Rose Miranda L. 
Published: February 2025

BACKGROUND:
Communicative ability after stroke influences patient outcomes. Limited research has explored the impact of aphasia when it intersects with cultural or linguistic differences on receiving stroke care and patient outcomes. We investigated associations between requiring an interpreter and the provision of evidence-based stroke care and outcomes for people with aphasia in the inpatient rehabilitation setting.

METHODS:
Retrospective patient-level data from people with aphasia were aggregated from the Australian Stroke Foundation National Stroke Audit–Rehabilitation Services (2016–2020). Multivariable regression models compared adherence to processes of care (eg, home assessment complete, type of aphasia management) and in-hospital outcomes (eg, length of stay, discharge destination) by the requirement of an interpreter. Outcome models were adjusted for sex, stroke type, hospital size, year, and stroke severity factors.

RESULTS:

Among 3160 people with aphasia (median age, 76 years; 56% male), 208 (7%) required an interpreter (median age, 77 years; 52% male). The interpreter group had a more severe disability on admission, reflected by reduced cognitive (6% versus 12%,
P
=0.009) and motor Functional Independence Measure scores (6% versus 12%,
P
=0.010). The interpreter group were less likely to have phonological and semantic interventions for their aphasia (odds ratio, 0.57 [95% CI, 0.40–0.80]) compared with people not requiring an interpreter. They more often had a carer (68% versus 48%,
P
<0.001) and were more likely to be discharged home with supports (odds ratio, 1.48 [95% CI, 1.08–2.04]). The interpreter group had longer lengths of stay (median 31 versus 26 days,
P
=0.005).

CONCLUSIONS:
Some processes of care and outcomes differed in inpatient rehabilitation for people with poststroke aphasia who required an interpreter compared with those who did not. Equitable access to therapy is imperative and greater support for cultural/linguistic minorities during rehabilitation is indicated.
منامات إخوان الصفا وخلّان الوفا: قراءة في شعريّة القصّ ومحمولاتها النسقيّة
Authors: الناصر دعد رشراش 
Published: February 2025

المستخلص
‫يقف البحث على منامات رسائل إخوان الصفا وخلّان الوفا، الموسوعة الفلسفيّة المؤلَّفة في القرن الرابع الهجريّ لجماعة من الأدباء وأصحاب الحكمة الذين آثروا أن يتقنّعوا ولا يعلنوا عن ذواتهم المؤلِّفة لغايات فكريّة وسياسيّة ظاهرة في الرسائل التي امتدّت على مساحة 51 رسالة علميّة، وكانت الرسالة الأخيرة جامعةً تختزل ما ذُكر في الموسوعة. كثّف الجزء الرابع من الرسائل تناوُله للمنامات بعنوان ”العلوم الناموسيّة الإلهيّة والشرعيّة،“ لتجيء هذه المنامات رمزيّةً تحمل دلالات فكريّة تتّسق مع أطروحات أهل الصفا؛ لذا فهي منامات صيغت لخدمة شرعيّة حضور هذه الفئة في مقابل الآخر الضالّ – كما ذُكر في الرسائل. هذا يجعل منطلَق البحث مرتكزًا على: (1) كون المنامات نصّا ثقافيًّا؛ واستدلالًا حجاجيًّا على اعتقاد أهل الصفا. وهو ما يشكّل حجّة البحث المركزيّة؛ و(2) دراسة المنامات ضمن منهجيّة النقد الثقافيّ الذي يفترض وجود تعارضات في المعنى: بين الظاهر والمحمولات النسقيّة. ويعمد البحث إلى تجلية المنامات المدروسة ضمن عنوانات مركزيّة تتناول بيان السرد، ومحمولاته النسقيّة، وشعريّته الجماليّة.‬
Hearing Loss Secondary to TECTA Gene Mutations
Authors: González-Aguado Rocío , Onecha Esther , Gallo-Terán Jaime , Morales-Angulo Carmelo 
Published: February 2025

Objectives: To assess the prevalence and clinical characterization of variants in the TECTA gene among individuals with bilateral sensorineural hearing loss of unknown etiology in northern Spain. Methods: A 6-year (2018-2024) observational, prospective, and descriptive study was conducted on patients with bilateral sensorineural hearing loss at a tertiary hospital. Next generation sequencing using a gene panel for sensorineural hearing loss was performed to detect pathogenic, likely pathogenic, or variants of unknown significance in the TECTA gene. Results: Among 326 patients, pathogenic or likely pathogenic TECTA variants were found in 7 patients (2.14%), including c.3107G>A (n = 6) and c.5383+6T>A (n = 1). Variants of unknown significance were found in 8 patients (2.45%). About 14 of 15 probands had a family history of hearing loss with autosomal dominant inheritance. Eight relatives with confirmed pathogenic variants were also included, totalling 23 cases. Six patients with pathogenic variants and 3 with variants of unknown significance had moderate mid-frequency hearing loss, while others had severe high-frequency loss. Hearing loss was typically progressive, ranging from congenital onset to the fifth decade. Most were treated with hearing aids; none required cochlear implants. Conclusions: TECTA gene variants are relatively common in this population, with c.3107G>A being the most frequent. The typical phenotype is slowly progressive, mid-to-high frequency sensorineural hearing loss, often starting in childhood and usually requiring hearing aids fitting with good results in improving speech intelligibility.
Mask Anesthesia, Straight Laryngoscope, and Alligator Forceps for Cervical Esophageal Coin Removal: A Comparison with Traditional Methods
Authors: Shah Hemali P. , Brawley Craig Cameron , Gabra Lauren , Maddalozzo John , Maurrasse Sarah , Johnston Douglas 
Published: February 2025

Objective(s): Coins are the most frequently ingested foreign bodies by children. While rigid esophagoscopy with concomitant intubation is frequently used for removal, it has the potential for serious complications. We aimed to assess and compare the safety, efficacy, and efficiency of two different techniques for pediatric cervical esophageal coin removal. Methods: Retrospective chart review identified patients who underwent esophageal coin removal from January 2017—August 2023 at one of two tertiary academic centers: Ann & Robert H. Lurie Children’s Hospital and Yale-New Haven Hospital. Patients with foreign bodies other than coins were excluded. Patients underwent one of two approaches for cervical esophageal coin removal depending on surgeon preference: (1) induction of general anesthesia, intubation, rigid esophagoscopy, and coin extraction with optical forceps (esophagoscope group) or (2) mask ventilation, insertion of a straight laryngoscope blade into the esophagus orifice, and coin extraction with alligator forceps (straight laryngoscope group). Primary outcomes were successful removal of the esophageal coin, regarded a marker of efficacy, as well as operative and anesthesia times, which were regarded as measures of efficiency. Secondary outcomes were postoperative complications, regarded as markers of safety. Results: Of the 108 patients meeting inclusion criteria, 23 (21.3%) were in the straight laryngoscope group and 85 (78.7%) in the esophagoscope group. Mean operative time was significantly shorter for the straight laryngoscope group compared to the esophagoscope group (2.8 ± 1.5 minutes vs 13.8 ± 17.2 minutes, respectively, p < .0001). Mean anesthesia time was significantly shorter for the straight laryngoscope group compared to the esophagoscope group (24.2 ± 6.4 minutes vs 44.7 ±1 6.2 minutes, respectively, p < .0001). There were no intra- or post-operative complications in the straight laryngoscope group and two minor complications in the esophagoscope group. Conclusions: Esophagoscopy using a straight laryngoscope blade under mask anesthesia can represent a safe and efficient alternative for impacted esophageal coin removal.
Diagnostic value and efficacy of multimodal magnetic resonance imaging in differentiating radiation necrosis from tumor recurrence in glioblastomas
Authors: Lv Xiao-Qiong , Shen Wen-Rong , Guo Zhen , Xie Xiao-Dong 
Published: February 2025

Background Distinguishing radiation necrosis (RN) from recurrent tumor (RT) in patients with gliomas treated with radiation therapy presents an important clinical dilemma. Purpose To evaluate the diagnostic performance of multiparametric magnetic resonance imaging (MRI) techniques in distinguishing RN from RT in patients with histologically confirmed glioma treated previously with radiotherapy and chemotherapy or without chemotherapy using a combination of dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion MRI, diffusion tensor imaging (DTI), and MR spectroscopy (MRS). Material and Methods Patients with glioma who developed a new enhancing mass after standard treatment were retrospectively evaluated. Conventional MRI, DTI, DSC, and MRS were performed. The region of interest (ROI) was manually drawn in the enhancing lesions, peri-lesional white matter edema, and the contralateral normal-appearing white matter. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), N-acetylaspartate (NAA), choline (Cho), creatine (Cr), NAA/Cr, Cho/NAA, and Cho/Cr were calculated. Two-tailed t-test and receiver operating characteristic (ROC) curve analysis were performed. Results In total, 34 patients with RT and 25 with RN met our inclusion criteria. FA, rCBF, rCBV, Cho/NAA, Cho/Cr were statistically significant between the two groups ( P < 0.05). The sensitivity and specificity of FA, rCBF, rCBV, Cho/NAA, and Cho/Cr in the diagnosis of RT were 70.6%, 97.1%, 91.2%, 91.2%, and 82.4% and 64%, 100%, 100%, 96%, and 72% respectively. Conclusion DTI, DSC, and MRS are of great value in the differential diagnosis of RN and RT of glioma. The diagnostic performance of DSC is better than DTI and MRS.
Brain and Spine Magnetic Resonance Imaging (MRI) Characteristics of a Pediatric Cohort With MOGAD
Authors: Doerfler Matthew , Zhang James , Rubin Jennifer , Jaju Alok , Aw-Zoretic Jessie 
Published: February 2025

Background and Objectives Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined demyelinating disorder with an age-related phenotypic spectrum. At disease onset, there is considerable clinical overlap between MOGAD and other demyelinating conditions, and it remains difficult to identify MOGAD radiographically. This study aims to further describe neuroimaging findings in the brain and the spine at presentation and throughout relapses in children with MOGAD. Methods We present a retrospective cohort study including all children presenting to a single center between 2010 and 2020 with acute demyelination who were positive for serum MOG-IgG antibodies and negative for serum aquaporin-4 antibodies. For each patient, magnetic resonance imaging (MRI) scans of the brain and spine at presentation and on each relapse were reviewed and categorized in a blinded fashion by 2 pediatric neuroradiologists. Results Sixteen patients met the inclusion criteria. Four had diffuse and bilateral fluid-attenuated inversion recovery signal in the white matter, but only on initial presentation. The area postrema was never affected. All 5 patients with optic neuritis had pre-chiasmatic (but not chiasmatic) involvement on presentation. The brachium pontis was involved in 3 patients on initial presentation, and in 8 patients at any time. Eleven patients demonstrated spinal cord involvement, and the cervical, thoracic, and lumbar regions were involved at similar frequencies. Discussion The radiographic features of MOGAD in children appear to reflect their presenting demyelinating syndromes. However, certain features, such as diffuse fluid-attenuated inversion recovery hyperintensities and expansile fluid-attenuated inversion recovery signal in the brachium pontis, may be more frequent in MOGAD compared with other demyelinating disorders.
Characteristic features of infants with pneumonia testing positive for specific immunoglobulin E
Authors: Hao Li , Wang Songqing , Ji Wei 
Published: February 2025

Objective To analyse the characteristic features of infants with pneumonia who test positive for serum milk-specific immunoglobulin E (sIgE) and to provide a reference for the diagnosis, management and prevention of the condition. Methods We retrospectively analysed data from 284 infants admitted to our hospital with pneumonia between January 2017 and December 2020 who underwent serum allergen testing. Based on the results, patients were categorised into three groups: pure milk sIgE-positive; mixed milk sIgE-positive; and allergen sIgE-negative. We then compared the general conditions, clinical characteristics, laboratory tests, imaging results and pathogenic data across these groups. Results Among the patient population, 16.20% (46/284) tested positive for pure milk sIgE, 32.75% (93/284) tested positive for mixed milk sIgE and 51.06% (145/284) were negative for any allergen sIgE. Statistically significant differences were observed among the three groups in terms of general conditions, breastfeeding status, pre-existing respiratory infections and history of respiratory infections (>3 times) ( p < 0.05 for each). The median length of hospital stay was longer in the pure milk sIgE-positive group and the mixed milk sIgE-positive group (8 [range 7–10] days) compared with the allergen sIgE-negative group (8 [range 6–9] days) ( p < 0.05). The eosinophil counts of the mixed milk sIgE-positive group were significantly higher than in the other two groups ( p < 0.05). Haemophilus influenzae of the pure milk sIgE-positive group was significantly higher than in the other two groups ( p < 0.05). Conclusion The presence of mixed milk sIgE allergens does not exacerbate clinical symptoms. However, infants who test positive solely for milk sIgE and have pneumonia require longer hospitalisation. This suggests that extra attention is necessary for infants with milk allergies when they develop pneumonia.
Embracing the Future: Artificial Intelligence in the Provision of Pre-Employment Transition Services to Autistic and Neurodivergent Youth
Authors: McDonald Hurford Rachel , Derry Melanie , Bavuso Elli 
Published: February 2025

Background Transition-aged youth with autism and other neurodiversities face high levels of unemployment and underemployment and can benefit from pre-employment and transition services to improve long-term outcomes. While the mainstream proliferation of artificial intelligence tools has garnered global attention over the last year, there is a growing body of research exploring how these technologies can be used to enhance communication and workplace readiness skills for these transition-aged youth. Objective This article examines the current state of artificial intelligence and technology integration into pre-employment and transition skills training for neurodivergent and autistic youth. Method We completed a scoping literature review across these topic areas, pre-employment services and artificial intelligence and technology for neurodivergent and autistic youth. Results We found the literature in this area of research to be in a state of rapid development and flux. A total of 27 articles were found. Specifically, there is literature describing the needs of neurodivergent and autistic youth in pre-employment services related to workplace readiness. Our review revealed promising advances in the use of technology and artificial intelligence to support the development of social communication and job-related skills for use in pre-ETS. Conclusions The proliferation of artificial intelligence and technology into mainstream society provides an opportunity to explore and hone the use of these tools to improve pre-employment and transition skills for neurodivergent youth. Stakeholders should engage in participatory and ethical practices to develop and implement strategies that improve workplace readiness and employment outcomes for this population.
Tenecteplase vs Reteplase in Patients with Acute ST-Elevation Myocardial Infarction: A Retrospective Cohort Study
Authors: Mohamed Adham , Mahmoud Sara , Fahmi Amr M. , Mahfouz Ahmed , Kanaan Tayseer , Jaber Jihad , Alkhawi Mansour , Alkhalaf Saleh , Kodimi Hassan , Shaaban Ahmed , Alshibli Omar , Almasalmeh Awad , Arafa Salaheddin , Elbdri Salah , Falah Suhail , Altrad Fayez , Soaly Ezeldin , Elenany Rasha , Alyafei Sumaya , Arabi Abdul Rahman 
Published: February 2025

Coronary artery disease is one of the leading causes of death globally. Despite the increased number of percutaneous coronary intervention (PCI) capable facilities, fibrinolytic therapy is still being utilized especially in rural areas. No studies have directly compared tenecteplase and reteplase in patients with ST-elevation myocardial infarction (STEMI). Purpose The aim of this study is to compare the efficacy and safety of both agents in patients with acute STEMI. Methods This was a multicenter retrospective observational study comparing tenecteplase and reteplase in patients with acute STEMI. The primary outcome was the incidence of failed thrombolysis. Secondary outcomes included the incidence of major bleeding, cardiogenic shock, re-infarction and mortality. Results A total of 282 patients were included, 229 and 53 received tenecteplase and reteplase, respectively. The incidence of failed thrombolysis was 33.2% in the tenecteplase group compared to 20.8% in the reteplase group (adjusted odds ratio 0.53, 95% confidence interval 0.25-1.1; p = 0.089). The incidence of major bleeding was 0.9% in the tenecteplase group and 5.7% in the reteplase group (p = 0.017). There was no significant difference in mortality or other secondary outcomes. Conclusion There was no difference in the primary outcome of failed thrombolysis between tenecteplase and reteplase; however, major bleeding events were significantly higher in the reteplase group. Randomized controlled trials are needed to confirm our findings.
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia
Authors: Shao Yunli , Qin Tong 
Published: February 2025

Background Acute myeloid leukemia (AML) prognosis varies greatly, underscoring the need for novel biomarkers to improve patient stratification. T-cell leukemia translocation-associated gene (TCTA) has emerged as a potential player in hematological malignancies, yet its role in AML remains unexplored. Objective To investigate the prognostic significance of TCTA in AML and elucidate its functional mechanisms. Methods RNA sequencing data from 173 AML patients (TCGA) and 70 normal controls (GTEx) were analyzed. Patients were categorized into high and low TCTA expression groups. Bioinformatics tools assessed Gene Ontology, KEGG pathways, and immune infiltration and constructed a nomogram predicting 1–5-year overall survival (OS). Results High TCTA expression correlated with significantly reduced OS ( P < 0.001), with multivariate analysis identifying TCTA expression alongside age and cytogenetic risk as independent OS predictors. Receiver operating characteristic analysis validated TCTA's diagnostic potential. Enrichment analyses implicated TCTA in pathways critical to AML, such as hematopoiesis, p53 signaling, and DNA methylation, with a notable association with natural killer (NK) cell activity. Conclusions Elevated TCTA expression signifies poor prognosis in AML, positioning it as a promising prognostic biomarker. Its involvement in key AML-related pathways highlights TCTA's functional relevance and potential as a therapeutic target in AML management.
Determination of Total Flavonoid Content and Phenolic Content, Antioxidant Assay, and Antiepileptic Activity of Achillea millefolium Extract
Authors: Hayat Sonia , Miana G. A. , Kanwal Madiha , Ahsan Zartab , Tariq Muhammad Junaid 
Published: February 2025

Objectives This study aimed to evaluate the antioxidant and antiepileptic potential of the ethanolic extract of Achillea millefolium aerial parts. Antioxidant activity was measured using DPPH photometric assay, and flavonoid content was quantified via the aluminum chloride method. The extract's neuroprotective effect was assessed using the pentylenetetrazole (PTZ)-induced seizure model, along with immunohistochemical (IHC) analysis and hematoxylin & eosin (H&E) staining. Methods The antioxidant potential of the extract was determined through DPPH radical scavenging activity, while flavonoid content was assessed as quercetin equivalents (QE). The in vivo antiepileptic activity was evaluated in mice using the PTZ-induced seizure model. Key biomarkers of oxidative stress, including glutathione (GSH), glutathione-S-transferase (GST), catalase, and lipid peroxidation (LPO), were measured to evaluate the extract's ability to ameliorate PTZ-induced oxidative stress. Results The extract demonstrated notable antioxidant activity, with 72% scavenging activity observed at 900 µg/mL. Flavonoid content was determined to be 39.45 ± 1.84 µg QE/mg. In the PTZ-induced seizure model, Achillea millefolium extract at 400 mg/kg and 600 mg/kg significantly reduced neuroinflammatory markers and oxidative stress, as evidenced by decreased LPO and increased levels of GSH, GST, and catalase. IHC and H&E staining revealed neuroprotective effects, including reduced neuroinflammation and enhanced neuronal survival. Conclusion The ethanolic extract of Achillea millefolium exhibited strong antioxidant and neuroprotective properties, effectively mitigating PTZ-induced seizures, oxidative stress, and inflammatory responses. These findings suggest its potential as a natural alternative for epilepsy treatment.
Concordance of maternal and cord blood SARS-COV-2 immunoglobulin seropositivity after COVID-19 infection or vaccination in pregnancy
Authors: Rojas Gladys , Jain Aarti , Bany-Mohammed Fayez , Felgner Philip , Aslam Muhammad , Uy Cherry C 
Published: February 2025

Objective To assess maternal antibody response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental antibody transfer in cord blood. Study Design This is a prospective cohort study of Coronavirus Disease 2019 (COVID-19) polymerase chain reaction (PCR) positive pregnant women and their newborns. SARS-CoV-2 PCR (+) women were enrolled, with SARS-CoV-2 PCR (−) as control. Maternal blood was obtained at enrollment and cord blood collected at delivery. Baseline maternal and infant characteristics and neonatal outcomes were collected. Samples were analyzed using coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2 (including nucleocapsid protein [NP], spike protein [S], S1, S2, receptor-binding domain [RBD]) which can detect SARS-CoV-2 immunoglobulin G (IgG) and immunoglobulin M (IgM). Results Thirty-seven maternal-cord blood paired samples were analyzed for SARS-CoV-2 IgG or IgM antibodies; 15 out of 20 samples from SARS-CoV-2 PCR (+) and 14 out of 17 from SARS-CoV-2 PCR (−) mothers were IgG positive. 14 out of the 17 SARS-CoV-2 PCR (−) mothers received COVID-19 vaccine during pregnancy. Difference between IgG seropositivity of naturally infected versus vaccinated mothers were significant, 75% versus 100% ( p = 0.043). IgM antibodies were detected in 10 out of 20 SARS-CoV-2 PCR (+) women but none were detected in cord blood. Conclusions Excellent concordance of SARS-CoV-2 IgG antibodies exist between maternal and cord blood. Significantly higher SARS-COV-2 cord blood IgG seropositivity was found in vaccinated versus naturally infected mothers.