bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quercetin stimulates trophoblast fusion via the mitochondrial function
Authors: Yoshida Kanoko , Kusama Kazuya , Shinohara Go , Sato Shiho , Yoshie Mikihiro , Tamura Kazuhiro 
Published: October 2023

Abstract
The fusion of mononuclear trophoblasts into multinucleate syncytiotrophoblasts is the critical event in the process of syncytialization, and its dysregulation can lead to pregnancy complications, notably hypertensive disorders of pregnancy (HDP). Oxidative stress may disrupt trophoblast syncytialization in HDP. Specifically, placentas with HDP exhibit impaired mitochondria, giving rise to the generation of reactive oxygen species (ROS) and subsequent oxidative stress. Quercetin, a bioflavonoid known for its antioxidant and anti-aging properties, has the potential to mitigate oxidative stress during trophoblast syncytialization. However, the precise mechanism underlying the action of quercetin in these processes remains to be elucidated. To explore the impact of quercetin on syncytialization, mitochondrial function, and ROS generation, cyclic AMP-stimulated BeWo cells were treated with quercetin. The expression of markers associated with cell fusion, mitochondrial function, and oxidative stress was determined using qPCR and western blotting. Additionally, morphological syncytialization and mitophagy (mitochondrial degradation) were assessed by immunofluorescence analysis. Our results revealed that quercetin increased the expression of syncytialization markers and promoted cell fusion. Furthermore, this compound also upregulated markers associated with mitophagy and mitochondrial fusion, which are corroborated by visual evidence of mitophagy through the fluorescence microscope. Cell fusion naturally stimulated ROS generation, which was attenuated by quercetin. Quercetin downregulated the expression of NRF2 and HO-1 during syncytialization, while increasing the expression of sirtuin1/3/6, which are known to play essential roles in antioxidant responses. In conclusion, quercetin effectively regulates mitochondrial function through its antioxidant properties and the suppression of ROS generation, ultimately promoting trophoblast fusion, suggesting that the flavonoid has the potential to ameliorate pregnancy-related disorder stemming from placental dysplasia.
Impaired striatal Glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy
Authors: Tully John , Pereira Andreia , Sethi Arjun , Griem Julia , Cross Ben , Williams Steven , Murphy Declan , Blair James , Blackwood Nigel 
Published: October 2023

Abstract
Men with antisocial personality disorder (ASPD) with or without psychopathy (+/-P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies. However, to date, no study has directly examined the potential neurochemical underpinnings of such abnormalities. We therefore investigated striatal glutamate: GABA ratio using Magnetic Resonance Spectroscopy in 30 violent offenders (16 ASPD-P, 14 ASPD+P) and 21 healthy non-offenders. Men with ASPD+/-P had a highly significant reduction in striatal glutamate : GABA ratio compared to non-offenders. We report, for the first time, striatal Glutamate/GABA dysregulation in ASPD+/-P, and discuss how this may be related to core behavioral abnormalities in the disorders.
Maternal Risk Factors Associated with Positive Infant Drug Toxicology
Authors: Pee Hannah , Kocherlakota Prabhakar , Hussein Karen 
Published: October 2023

Abstract

Background: Identifying substance use disorder (SUD) during pregnancy is challenging as there is no general consensus on which pregnant women should be tested for SUD during pregnancy. Recent studies have shown that a criteria-based approach may be essential for toxicological testing.
Objective: To identify maternal and neonatal risk factors associated with positive neonatal drug toxicology results.
Design/Methods: A retrospective chart review of mothers and their delivered infants from 2016 to 2022 at Montefiore St. Luke's Cornwall Hospital, Newburgh, NY. Urine, umbilical cord, and meconium were analyzed for toxicological testing.
Results: Of the 5488 deliveries, 10.2% of mothers had risk factors, and 5.4% of dyads had positive toxicology results. Mothers with recent substance use disorder (SUD), including SUD on medication-associated treatment (MAT), infants with withdrawal signs, small for gestational age (SGA), and exposure to sexually transmitted infections (STD) had positive toxicology results.
Conclusion: Insufficient prenatal care, the most common indication for toxicology testing, was not associated with positive toxicology results.
The Well-Being of Social-Health Professionals: Relationship Between Coping Strategies, Emotion Regulation, Metacognition and Quality of Professional Life
Authors: Ferro Laura , Cariello Marina , Colombesi Alessandra , Adduci Chiara , Centonze Eleonora , Baccini Giorgia , Cristofanelli Stefania 
Published: October 2023

Abstract
Background
Social-health professionals should have knowledge, skills, and use personal resources that promote the helping relationship, access to effective intervention strategies, and well-being at work. In this professional group, the risk of developing burnout is common and the quality of professional life is strongly related to the intensity and frequency of exposure, including indirect exposure, to critical and traumatic events. In particular, social and health care professionals working with minors face great challenges, emotionally, metacognitively, and in terms of stress management. This study aims to investigate the relationship between some personal resources (coping strategies, emotional regulation and metacognition) and professional satisfaction in a group of social-health professionals working with minors suffering from psychosocial distress.
Method
Social-health professionals who work with minors completed self-assessment measures relating to the Professional Quality of Life Scale (PRQOL), Coping Orientation to the Problems Experienced—New Italian Version (COPE-NVI), Difficulties in Emotional Regulation Scale (DERS) and Metacognition Self-Assessment Scale (MSAS).
Results
The quality of professional life showed some significant correlations with the psychological characteristics studied. linear regression analysis using the dimensions measured by PRQOL as dependent variables. We then tested several regression models using the dimensions COPE, MSAS, and DERS as independent variables. MSAS showed no significance with any of the three PRQOL dimensions. Otherwise, COPE proved to be a significant predictor of quality of professional life for all three components. The DERS appears to predict only the burnout component.
Conclusions
The quality of professional life of social-health professionals who work with minors affected by psychosocial problems is influenced by individual resources at different levels, regardless of knowledge and skills. They show greater fatigue and aspects of secondary traumatization when emotional disengagement occurs and it seems difficult to accept their emotional reactions. Appropriate spaces for reflection and sharing can modulate maladaptive use of avoidance and promote caring relationships with minors.
Surgery for T4 rectal cancer- is treatment planning based on response MRI safe?
Authors: Ballal Devesh S , Raj Prudvi , M Janesh , Kazi Mufaddal , Desouza Ashwin , Ankathi Suman K. , Engineer Reena , Saklani Avanish P. 
Published: October 2023

Abstract
Introduction

There is no clear consensus on using the response-MRI as opposed to the pretreatment-MRI for surgical planning in cT4 low rectal cancer.

Methods

Retrospective review of a database of abdominoperineal resections conducted at a single tertiary cancer center. Patients divided into 2 groups- Group A (clinical T3 and mesorectal fascia positive) and Group B (clinical T4) with the primary outcome being rate of pathological circumferential resection margin positivity. After propensity score matching, factors influencing pathological circumferential resection margin positivity were analysed using logistic regression.

Results

There were 237 patients in Group A and 127 in Group B, in the unmatched cohort, with a significantly higher number of females (43.3% vs 28.7%, p=0.005) and anterior circumferential resection margin positivity (68.5% vs 49%, p<0.001), with a lower number of patients receiving neoadjuvant chemotherapy in Group B (38.6% vs 49.8%, p=0.041). After propensity matching baseline characters were comparable. There was a higher percentage of extended-Total Mesorectal Excisions in group B (58.5% Vs 40.5%, p=0.004). The rate of pathological circumferential positivity was comparable in both groups (20/168 in Group A{11.9%} Vs 13/107 in Group B{12.1%}, p=0.951) with no impact of group on circumferential resection margin positivity on univariate (OR 1.023, p=0.951) or multivariate regression (OR 0.993, p=0.987). Both the DFS (median DFS 39 months Vs 54 months, p=0.970) and OS (3-year OS 72% Vs 67%, p=0.798) were comparable between groups.

Conclusion

For T4 low rectal cancers, post-treatment MRI can be used for surgical planning without any detriment in outcomes.
Radiographic Evaluation of Pulmonary Embolus Study at Mouwasat University Hospita On the Radiological Signs of pulmonary embolus On plain chest images and CT scans.
Authors: Aldahouk Yara , khattab Khalid , Sallom Nmr 
Published: October 2023

Abstract

Pulmonary embolism results from an emboli in any part of the pulmonary circulation, it is usually caused by avenous thrombosis in the deep veins, Risk factors for pulmonary embolism include three basic forms called Virchow triad: Vascular trauma, Increased coagulability, Reduced blood flow, The clinical manifestations of pulmonary embolism are nonspecific, but their presence with one of the risk factors leads to pulmonary embolism, and then we carry out appropriate investigations and measures, Plain chest X-ray is often non directional and is used to ruleout symptoms clinically similar to pulmonary embolus, Pulmonary angiography is currently considered the gold standard for diagnosis, It is often performed using the multishider technique, wich has asensitivity and specificity equal to contrast angiography, but it is a non – invasive procedure and is therefore more widely used
One in Six Children and Adolescents in South Ethiopia Had Childhood trauma
Authors: Berhanu Tamene , Tesfaye Yonas , Girma Shimelis , Abera Mubarek 
Published: October 2023

Abstract

Background: Trauma in childhood is a serious experience that can affect the physical, psychological, and social development of the child and adolescent and has immense long-term effects on the child, and society. However, the condition is overlooked by parents, teachers, medical professionals, mental health practitioners, and researchers. Hence this study aimed to assess childhood trauma and its associated factors among children and Adolescents aged 5–14 years old at Wolaita Sodo University Comprehensive Specialized Hospital, South Ethiopia, in 2022.
Method: From 22 September to 22 November, 2022, a hospital-based cross-sectional study was conducted, at Wolaita Sodo University Comprehensive Specialized Hospital. About 423 study participants were selected using a systematic random sampling technique. Data was collected using a structured interviewer administered questionnaire. Childhood trauma was screening using the Child trauma screening questionnaire. The data was analyzed using descriptive and logistic regression analysis methods. The strength as well as presence of association was presented using odds ratio and 95% CI with a corresponding p-value < 0.05.
Result: The magnitude of childhood trauma among children and Adolescents aged 5–14 was17.5%. Large family size (AOR = 1.8; 95% CI: 1.07, 3.13), educational level of parents (AOR = 4.4; 95% CI: 2.18, 9.00), and children and adolescent emotional problems (AOR = 1.9; 95% CI: 1.09, 3.20) were significantly associated with childhood trauma
Conclusion and Recommendation: Approximately one in six children and adolescents had experienced childhood trauma. Large family size, educational level of parents, and emotional problems of children and adolescents were factors associated with childhood trauma. Therefore, a holistic preventive approach and early detection and management are important to halt the short and long-term impact of childhood trauma.
Dynamic De-identification Protection Adaptation for Sensitive User Data Scenarios in Virtual Power Plant
Authors: Shi Congcong , Yang Ruxia , Fei Jiaxuan , Liu Shidong , Tao Jing , Wu Jiawei 
Published: October 2023

Abstract

Virtual power plants serve as comprehensive dispatch platforms for load usage, energy supply, and market transactions in various scenarios. During the processing of distributed resource information, sensitive data of multiple users are involved. Traditional static desensitization methods face two challenges: difficulty in intelligent classification of multi-scene data and low efficiency in desensitization processing for different security requirements. To address these issues, this paper proposes a dynamic desensitization protection method based on scene adaptation of sensitive data in virtual power plants. The method utilizes machine learning techniques to achieve intelligent scene recognition and automatically selects the privacy protection strength based on the identified scene for dynamic desensitiza-tion of sensitive data. The proposed method introduces a novel similarity utility function that incorporates the concept of similarity and adaptively evaluates the similarity between scenes. This enables the method to perform scene recognition in an adaptive manner. Furthermore, a differential privacy algorithm based on Gaussian processes is employed to determine the privacy security parameters, ensuring privacy protection based on the identified business scenario. Experimental results demonstrate that when an appropriate privacy budget is selected, the proposed method achieves a recognition accuracy rate of 87.5%. This confirms the method’s effectiveness in terms of usability and security, as it successfully achieves differentiation in differential privacy protection and dynamic desensitization strategies corresponding to different scenarios. The proposed method provides a valuable contribution to the field by enabling dynamic desensitization protection of sensitive data in virtual power plants.
Association of Coffee and Caffeine Intake with Risk of Chronic Obstructive Pulmonary Disease: Findings Based on NHANES 2007-2012
Authors: Liao Wan-Zhe , Li Jia-Xin , Feng Wei-Yi , Xiao Jia-Qi , Wang Zi-Xun , Xie Shuo-Jia , Hu Yi-Ming , Mao Jum-Hao , Huang Ze-Min , Guan Wei-Jie , Guo Xu-Guang 
Published: October 2023

Abstract
Objectives
This investigation aimed to examine the correlation between coffee and caffeine intake with the risk of COPD and lung function based on NHANES 2007-2012.
Materials and Methods
Exposure variables were established as coffee and caffeine consumption, while the risk of COPD and lung function were considered as the outcome variables. Other covariates were deemed potential confounders. A cross-sectional study was conducted using data from the NHANES to determine a definitive correlation between exposure variables and outcome variables.
Results
Multivariable regression models revealed positive associations between coffee and caffeine consumption and the risk of COPD and lung function. Subgroup analyses, stratified by sex, DM, hypertension status, and smoking habits, identified potential effect modifiers, as well as infection points from threshold effect examinations.
Conclusions
The results of this cross-sectional study indicated significant positive associations between coffee and caffeine consumption and the risk of COPD. Additionally, positive associations between exposure variables and FEV1 and FVC were discovered. Among the stratification factors, smoking status exhibited the most potential for modifying effects.
Trajectories of school refusal: sequence analysis using retrospective parent reports
Authors: BENOIT Laelia , PENG Edith CHAN SOCK , FLOURIOT Julien , DIGIOVANNI Madeline , BONIFAS Nicolas , ROUQUETTE Alexandra , MARTIN Andrés , FALISSARD Bruno 
Published: October 2023

Abstract
Background
School refusal (SR) is a form of school attendance problem (SAP) that requires specific mental health care. Despite improvements in the definition of SAPs, the course of SR is not well characterized.
Methods
To explore three-year patterns of SR course in children, as reported by their parents, we deployed an anonymous web-based survey. We defined SR onset as the absence of ≥ 2 school weeks during one academic year, combined with emotional distress. We defined standard SR trajectories using sequence analysis of parents’ recollection of three consecutive years of school attendance.
Results
We obtained 1,970 responses, 1,328 (67%) completed by a parent and meeting the definition of SR. Of these, 729 (55%) responses included three years of school attendance recollection. We identified five prototypical trajectories of SR: two profiles for children: beaded absences (n = 272), and rapid recovery (n = 132); and three for adolescents: prolonged recovery (n = 93), gradual decline (n = 89), and rapid decline (n = 143).
Conclusion
We found five distinct trajectories of retrospective recall of SR course. Through pattern recognition, this typology could help with timely identification of SR and implementation of evidence-based interventions to optimize outcomes. Prospective replication of these findings and their field application is warranted.
NaGdF 4 @ PEG-CLS@ MMP-13 cartilage-binding peptide NPs as a safe and effective MRI contrast agent for articular cartilage injury
Authors: Xu Jian , Zhang Yijun , Lin Mao , Ma Binbin , He Hongpu , Jiang Fangyi , He Shukun , Yuan Chengjie 
Published: October 2023

Abstract
Background
The precise and early detection of cartilage injuries bears immense significance, given their innate lack of self-healing capacity and propensity to cause joint dysfunction. Regrettably, the clinically conventional contrast agents, such as gadolinium-diethylenetriamine-pentaacetic acid (Gd-DTPA) with low longitudinal T1 relaxivity (r1) and a dearth of specificity limitted the MRI applications;
Methods
This study focused on NaGdF4 nanoparticles (NPs), subsequently augmenting their hydrophilicity and lipophilicity via polyethylene glycol (PEG) and cholesterol (CLS) modifications.Matrix metalloproteinase-13 (MMP13) cartilage binding peptide (CBP) was harnessed to confer targeting capabilities. NaGdF4@PEG-CLS@MMP13 CBP NPs exhibited an elevated r1 value (8.07 mM − 1 s − 1) when juxtaposed with NaGdF4@PEG-CLS NPs (6.65 mM − 1 s − 1) and Gd-DTPA (3.01 mM − 1 s − 1);
Results
This NPs enhanced its affinity to cartilage and facilitated deeper penetration beyond the cartilage surface. Consequently, the NaGdF4@PEG-CLS@MMP13 CBP NPs instigated a notable enhancement in the quality of cartilage and lesion MR images. Specifically, a mere 2 hours following NP administration, the signal-to-noise ratio (SNR) at the injured cartilage site exhibited a remarkable 2.4-fold escalation in comparison to its pre-injection counterpart. Furthermore, the biocompatibility profile of NaGdF4@PEG-CLS@MMP13 CBP NPs proved favorable, with no observed adverse effects in blood samples or major organs;
Conclusions
This study demonstrated that Gd NPs underwent initial metabolism in the kidneys and liver, followed by excretion through urine. The cumulative evidence firmly positions NaGdF4@PEG-CLS@MMP13 CBP NPs as a promising and effective MRI contrast agent, poised to advance the early detection capabilities of cartilage injuries.
New analytical solutions of fractional (HIV-1 infection of CD4 + T-cells) using two efficient methods
Authors: Alshahrani Maryam , Ouahid Loubna , Abdou M. A. , Kumar Sachin , Shahrani Jameelah S. Al 
Published: October 2023

Abstract
Here, we use a fractional model to perform an analytical investigation of (HIV-1 infection of CD4+ T-cells). This considered model is analyzed by utilizing a new extended sub-equation method as well as a direct algebraic method. The obtained results demonstrate the influence and superiority of the applied schemes over other analytical methodologies. The series of single solutions with a fractional derived in order achieved with these methods can be classified as trigonometric, hyperbolic, rational, and other basic functions. A comparison of analytical method results is discussed. We also offer some figures showing how exact the solutions are obtained using the two new analytical methods.
A dense tolerance to water stress: Coordination between water relations strategy and carbon investment in leaf and stem across six fruit tree species
Authors: Piña Ismael , Garrido Marco , Seguel Oscar , Opazo Ismael , Faúndez Carlos , Verdugo-Vásquez Nicolás , Villalobos-Soublett Emilio 
Published: October 2023

Abstract

The water relation strategy of a species (iso-anisohydric continuum as one of the most widely used definitions) is a key issue in the context of climate change. Given the difficulty of determining water relations strategy, there is a need for simple traits with a solid theoretical basis to estimate it. Among the many possibilities, traits associated with the "fast-slow" plant economics spectrum are particularly interesting. Avocado, Fig, Mandarin, Olive, Pomegranate, and Vine were characterized in terms of stomatal behavior, water potential at the turgor loss point (TLP), and Hydroscape Area, and the association of these metrics with leaf mass per area (LMA) and wood density (WDen) was explored. Our results showed high coordination between LMA and WDen across the six species, and both traits were related to metrics of water relation strategy. Species with less regulation of their water status tended to invest a greater amount of carbon per unit leaf area or unit stem volume with implications over hydraulic efficiency and water stress tolerance. WDen and TLP were the most powerful traits in estimating the water relation strategy for six fruit species. These traits are easy to measure, time-cost efficient, and appear central to coordinating multiple traits and behaviors along the water relations strategies. It is important to improve the understanding of these traits and their intraspecific variability to advance the understanding of how species and cultivars will respond to future scenarios and to design better selection, breeding, and agronomic strategies for climate change adapted agriculture.