bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the predictive significance of systemic immune-inflammatory index and tumor markers in lung cancer patients with bone metastases
Authors: He Jinxian , Liang Gaofeng , Yu Hongyan , Lin Chengbin , Shen Weiyu 
Published: January 2024

ObjectiveThis study aims to develop a predictive model for identifying lung cancer patients at elevated risk for bone metastases, utilizing the Unified Immunoinflammatory Index and various tumor markers. This model is expected to facilitate timely and effective therapeutic interventions, especially in the context of the growing significance of immunotherapy for lung cancer treatment.MethodsA retrospective analysis was conducted on 324 lung cancer patients treated between January 2019 and January 2021. After meeting the inclusion criteria, 241 patients were selected, with 56 exhibiting bone metastases. The cohort was divided into a training group (169 patients) and a validation group (72 patients) at a 7:3 ratio. Lasso regression was employed to identify critical variables, followed by logistic regression to construct a Nomogram model for predicting bone metastases. The model’s validity was ascertained through internal and external evaluations using the Concordance Index (C-index) and Receiver Operating Characteristic (ROC) curve.ResultsThe study identified several factors influencing bone metastasis in lung cancer, such as the Systemic Immune-Inflammatory Index (SII), Carcinoembryonic Antigen (CEA), Neuron Specific Enolase (NSE), Cyfra21-1, and Neutrophil-to-Lymphocyte Ratio (NLR). These factors were incorporated into the Nomogram model, demonstrating high validation accuracy with C-index scores of 0.936 for internal and 0.924 for external validation.ConclusionThe research successfully developed an intuitive and accurate Nomogram prediction model utilizing clinical indicators to predict the risk of bone metastases in lung cancer patients. This tool can be instrumental in aiding clinicians in developing personalized treatment plans, thereby optimizing patient outcomes in lung cancer care.
Adverse event reporting of four anti-Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a real-world study based on the FDA adverse event reporting system
Authors: Sun Wenfang , Li Yali , Xia Binbin , Chen Jing , Liu Yang , Pang Jingyao , Liu Fang , Cheng Hua 
Published: January 2024

Background: Anti-Calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) have shown significant efficacy in preventing migraine. However, there have been limited reports of adverse events (AEs) after marketing, particularly for eptinezumab launched in 2020. The study aimed to mine and analyze the AE signals with four anti-CGRP mAbs from the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to gain insights into the safety profile of these medications post-marketing.Methods: All AE reports on the four anti-CGRP mAbs (erenumab, galcanezumab, fremanezumab, and eptinezumab) were retrieved from the FAERS database from the first quarter (Q1) of 2018 to Q1 of 2023. Disproportionality analysis was measured by reporting odd ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) to identify potential AE signals. Comparisons were made between the four drugs in terms of AEs.Results: A total of 38,515 reports of erenumab, 19,485 reports of galcanezumab, 5,332 reports of fremanezumab, and 2,460 reports of eptinezumab were obtained, mostly reported in the second to third year after launch in the market. The common AEs to erenumab included constipation (17.93%), injection site pain (14.08%), and alopecia (7.23%). The AEs that occurred more frequently with galcanezumab included injection site pain (24.37%), injection site erythema (5.35%), and injection site haemorrhage (4.97%). Common AEs related to fremanezumab were injection site pain (13.10%), injection site erythema (7.02%), and injection site pruritus (5.47%). Fatigue (13.54%), throat irritation (9.02%), and pruritus (8.20%) were the most common AEs with eptinezumab. In addition, there are new AEs that were not listed in the drug instructions but occurred concurrently with multiple drugs, such as Raynaud’s phenomenon, weight increase, menstrual disorders, throat tightness, and paraesthesia oral.Conclusion: Common AE signals of the four anti-CGRP mAbs and new AE signals were found to provide a reference for clinical drug selection in clinical practice.
Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study
Authors: Chen Yewei , Shen Qian , Xiong Ye , Dong Min , Xu Hong , Li Zhiping 
Published: January 2024

Objectives: Rituximab is frequently used off-label for the treatment of frequent-relapsing/steroid-dependent nephrotic syndrome (FRNS/SDNS). However, the optimal dosing schedules remain undetermined. The objective of this study was to establish a population pharmacokinetic-pharmacodynamic (PK-PD) model in pediatric patients with FRNS/SDNS, and to investigate dosing regimens that provide adequate suppression of B lymphocytes.Methods: A prospective, open-label, single-center study was conducted in Nephrology Department at Children’s Hospital of Fudan University, and a two-compartment PK model of rituximab in pediatric FRNS/SDNS has been developed previously by our group. CD19+ lymphocyte count profiles were obtained from these patients. The presence of anti-rituximab antibodies was assessed prior to medication in children who had previously received rituximab or during follow-up at the last sampling point for PK analysis. PK-PD analyses were performed to describe the changes of CD19+ lymphocytes, with rituximab assumed to increase their death rate. Monte Carlo simulation was conducted to evaluate different dosing regimens.Results: In total, 102 measurements of CD19+ lymphocyte counts were available for PK-PD analysis. No detectable levels of anti-rituximab antibodies were observed during the PK follow-up period. A turnover model with saturable stimulatory action of rituximab on the removal of lymphocytes best characterized the relationship between rituximab concentration and CD19+ lymphocyte counts, where the Emax and EC50 were estimated to be 99.6*106/L and 5.87 μg/mL, respectively. Simulations indicated that a single infusion of 750 mg/m2 and 2 infusions of 375 mg/m2 both yielded a 10-week suppression of CD19+ lymphocytes.Conclusion: This study represents a first attempt to quantitatively describe the PK-PD relationship of rituximab in pediatric patients with FRNS/SDNS, and provide a potential pathway for future precision dosing strategy for rituximab therapy. Further clinical studies are warranted to evaluate the efficacy and safety of different dosing schemes.
Transcriptome analysis and immune gene expression of channel catfish (Ictalurus punctatus) fed diets with inclusion of frass from black soldier fly larvae
Authors: Sankappa Nithin Muliya , Lange Miles D. , Yildirim-Aksoy Mediha , Eljack Rashida , Kucuktas Huseyin , Beck Benjamin H. , Abernathy Jason W. 
Published: January 2024

The larval waste, exoskeleton shedding, and leftover feed components of the black soldier fly and its larvae make up the by-product known as frass. In this study, we subjected channel catfish (Ictalurus punctatus) to a 10-week feeding trial to assess how different dietary amounts of frass inclusion would affect both systemic and mucosal tissue gene expression, especially in regard to growth and immune-related genes. Fish were divided in quadruplicate aquaria, and five experimental diets comprising 0, 50, 100, 200, and 300 g of frass per kilogram of feed were fed twice daily. At the end of the trial, liver, head kidney, gill, and intestine samples were collected for gene expression analyses. First, liver and intestine samples from fish fed with a no frass inclusion diet (control), low-frass (50 g/kg) inclusion diet, or a high-frass (300 g/kg) inclusion diet were subjected to Illumina RNA sequencing to determine global differential gene expression among diet groups. Differentially expressed genes (DEGs) included the upregulation of growth-related genes such as glucose-6-phosphatase and myostatin, as well as innate immune receptors and effector molecules such as toll-like receptor 5, apolipoprotein A1, C-type lectin, and lysozyme. Based on the initial screenings of low/high frass using RNA sequencing, a more thorough evaluation of immune gene expression of all tissues sampled, and all levels of frass inclusion, was further conducted. Using targeted quantitative PCR panels for both innate and adaptive immune genes from channel catfish, differential expression of genes was identified, which included innate receptors (TLR1, TLR5, TLR9, and TLR20A), proinflammatory cytokines (IL-1β type a, IL-1β type b, IL-17, IFN-γ, and TNFα), chemokines (CFC3 and CFD), and hepcidin in both systemic (liver and head kidney) and mucosal (gill and intestine) tissues. Overall, frass from black soldier fly larvae inclusion in formulated diets was found to alter global gene expression and activate innate and adaptive immunity in channel catfish, which has the potential to support disease resistance in this species in addition to demonstrated growth benefits.
DPXception: a lightweight CNN for image-based date palm species classification
Authors: Safran Mejdl , Alrajhi Waleed , Alfarhood Sultan 
Published: January 2024

IntroductionDate palm species classification is important for various agricultural and economic purposes, but it is challenging to perform based on images of date palms alone. Existing methods rely on fruit characteristics, which may not be always visible or present. In this study, we introduce a new dataset and a new model for image-based date palm species classification.MethodsOur dataset consists of 2358 images of four common and valuable date palm species (Barhi, Sukkari, Ikhlas, and Saqi), which we collected ourselves. We also applied data augmentation techniques to increase the size and diversity of our dataset. Our model, called DPXception (Date Palm Xception), is a lightweight and efficient CNN architecture that we trained and fine-tuned on our dataset. Unlike the original Xception model, our DPXception model utilizes only the first 100 layers of the Xception model for feature extraction (Adapted Xception), making it more lightweight and efficient. We also applied normalization prior to adapted Xception and reduced the model dimensionality by adding an extra global average pooling layer after feature extraction by adapted Xception.Results and discussionWe compared the performance of our model with seven well-known models: Xception, ResNet50, ResNet50V2, InceptionV3, DenseNet201, EfficientNetB4, and EfficientNetV2-S. Our model achieved the highest accuracy (92.9%) and F1-score (93%) among the models, as well as the lowest inference time (0.0513 seconds). We also developed an Android smartphone application that uses our model to classify date palm species from images captured by the smartphone’s camera in real time. To the best of our knowledge, this is the first work to provide a public dataset of date palm images and to demonstrate a robust and practical image-based date palm species classification method. This work will open new research directions for more advanced date palm analysis tasks such as gender classification and age estimation.
Workplace bullying and sexual harassment at work among hotel housekeepers in the Balearic Islands (Spain)
Authors: Chela-Alvarez Xenia , Bulilete Oana , García-Buades M. Esther , Ferrer-Perez Victoria A. , Llobera Joan 
Published: January 2024

IntroductionHotel housekeepers are close to being a 100% feminized occupational group in Spain. This fact, coupled with some features of the job, places them at high risk of sexual harassment at work and bullying in the workplace. This study aims to explore experiences of sexual harassment at work and workplace bullying among hotel housekeepers in the Balearic Islands. Second, it aims to describe and estimate the prevalence of both phenomena.MethodsThis is a mixed-methods study. Ten semi-structured interviews were conducted with key informants, and six focus groups were held with hotel housekeepers. Additionally, a quantitative cross-sectional study (n = 1,043) was undertaken.ResultsMost participants in focus groups had been sexually harassed at work. However, they had normalized this kind of situations, not labeling themselves as victims of sexual harassment; and harassment events were seen as unimportant, normal, and unquestioned, as well as being part of their daily work. Hotel housekeepers who were sexually harassed indicated high levels of stress at work and low social support. The prevalence of different workplace bullying behaviors was quite high among hotel housekeepers working in the Balearic Islands. Some were associated with poorer self-rated health, less satisfaction with the job and the salary, lower social support, and higher levels of stress. Despite this, qualitative methods informed us that less severe behaviors were normalized and perceived by hotel housekeepers as intrinsic to their job.DiscussionThe results show the high tolerance to less severe expressions of sexual harassment at work and workplace bullying, as well as difficulties in or reluctance to labeling this kind of experiences as such.
A protocol for a critical realist synthesis of school mindfulness interventions designed to promote pupils’ mental wellbeing
Authors: Abbott Pamela , Nixon Graeme , Stanley Isabel , D’Ambruoso Lucia 
Published: January 2024

IntroductionThe review described in this protocol will be the first critical realist review of the literature reporting on the impact of school-based mindfulness interventions on the mental wellbeing of pupils. Mindfulness interventions are increasingly being introduced into schools to promote children’s (and teachers’) wellbeing. Findings from impact evaluations, including systematic reviews and metanalysis, suggest that school-based mindfulness interventions promote pupils’ wellbeing. However, there is a need for further evidence on the underlying causal mechanisms and contexts that explain program outcomes, to provide insight into how mindfulness programs can be successfully implemented in other contexts.Methods and analysisA critical realist review methodology will be used to provide a causal interdisciplinary understanding of how school-based mindfulness interventions promote the mental wellbeing of pupils. This will be done through a systematic literature review and extrapolating context, agency, intervention, mechanisms, and outcome configurations. This will enable an understanding of how, in certain contexts, pupils can use the resources offered by a mindfulness intervention knowingly or unknowingly to trigger mechanisms that promote their mental wellbeing and what mechanisms in the context support, restrict or prevent change. We will then use retrodiction and retroduction to develop the most plausible interdisciplinary middle-range theory to explain the findings.DiscussionThe review findings will inform a critical realist evaluation of a mindfulness intervention in schools. The findings from the review will also enable us to inform policymakers and other stakeholders about what conditions need to be in place for mindfulness interventions to promote pupils’ mental wellbeing. We will publish the findings from the review in academic and professional publications, policy briefs, workshops, conferences, and social media.PROSPERO registration number: CRD42023410484.
Comment des monitrices situent leur role auprès des femmes immigrées en formation
Authors:   CIMADE
Published: January 2024

On lira, ci-dessous, les réflexions d'un groupe de monitrices, consécutives à une rencontre, à la Cimade - Paris les 31 mai et 1er juin 1 975, entre femmes immigrées (maghrébines et africaines) et monitrices françaises.
L'échange de nos expériences montre que deux catégories de femmes immigrées viennent au cours : « les femmes ne travaillant pas, d'âge moyen, ayant beaucoup d'enfants », et « les femmes travaillant, ayant peu ou pas d'enfants ».
Femmes du Sud-Est asiatique
Authors: Duong Mademoiselle , Bonis Madame , Tra Madame 
Published: January 2024

Depuis mars 1975, en raison des événements politiques, la France a vu arriver, sur son sol, un nombre relativement important de réfugiés du Sud-Est Asiatique.
Les femmes immigrées, originaires de cette région du globe, posent des problèmes particuliers. Nous avons demandé à des assistantes sociales du SSAE de les préciser.
Septembre 1984. L'anthropologie dans la formation des enseignants
Authors: Abdallah-Pretceille Martine 
Published: January 2024

Martine Abdallah-Pretceille, auteur en 1982 de Des enfants non francophones à l’école : quel apprentissage ? Quel français ?, analyse ici les rapports interpersonnels et intergroupes à travers la dynamique interculturelle. Comment un pédagogue peut-il développer sa compréhension des problèmes éducatifs en s’aidant de l’anthropologie ? Dans quelle perspective interculturelle ?
Septembre 2005. Laïcité et minorités
Authors: Cohen Martine 
Published: January 2024

La laïcité française est réputée assurer à tous une liberté de conscience et de religion, ainsi que l’égalité entre tous les groupes religieux, du fait d’une loi de séparation qui ne « reconnaît » aucun d’entre eux, plus précisément aucun « culte ». Les minorités religieuses seraient ainsi mises sur un pied d’égalité avec la religion socialement majoritaire en France, le catholicisme. Du pluralisme religieux au pluralisme culturel, la laïcité française doit faire face à de nouveaux défis.
Septembre 1987. La galère, jeunes en survie
Authors: Dubet François 
Published: January 2024

Cet ouvrage repose sur des entretiens approfondis entre des groupes de jeunes de quartiers difficiles (à Seraing, Vénissieux, Orly, Sartrouville, Champigny et Clichy) et des équipes de sociologues et d'intervenants sociaux. Il analyse de façon assez sombre l'univers de galère de ces jeunes.
Le passage, extrait du chapitre XVI, que nous reproduisons ici avec l'aimable autorisation de l'éditeur, traite plus précisément des jeunes issus de l'immigration dans le cadre de la cité des Minguettes à Vénissieux et introduit une note plus positive. Les jeunes immigrés, s'ils sont plus enfoncés dans la galère que les jeunes Français, manifestent par ailleurs de plus grandes capacités de renverser les logiques de celle-ci. Quant au racisme il semble absent des relations entre les jeunes eux-mêmes.
Juin 2000. Violence à l'école : la dimension « ethnique » du problème
Authors: Charlot Bernard 
Published: January 2024

Longtemps sujet tabou, les discriminations sur la base ethnique au sein de l'école sont aujourd''hui renforcées par les évolutions des politiques scolaires.
Les ségrégations contribuent à engendrer un climat de violence. Les contradictions vécues par les différents acteurs de l'éducation des quartiers populaires, en proie au désarroi, et les rapports de force au sein de l'institution tendent à être de plus en plus perçus au travers d''une grille de lecture ethnique, tant chez les jeunes que chez les adultes.
Sortir de cette logique implique entre autres d'inventer une symbolique mobilisatrice, qui réconcilie égalité politique et égalité sociale, et des pratiques considérées comme légitimes par tous.
Análise da estabilidade global em edificações de pequeno porte
Authors: Fontoura Nayra Consentino , Milani Alisson Simonetti , Budny Jaelson , Hartmann Diego Arthur 
Published: January 2024

O coeficiente é um parâmetro de estabilidade amplamente utilizado no Brasil, contudo possuí aplicação limitada para 4 pavimentos, devido a orientação da NBR 6118 (2023), que permite a utilização de redutores de rigidez como consideração aproximada dos efeitos da não linearidade física (NLF). Objetivo deste trabalho é avaliar a estimativa dos efeitos de 2ª ordem do coeficiente em edificações de 2 e 3 pavimentos e, verificar a influência da variação dos redutores de rigidez nos resultados do coeficiente . Foram realizadas simulações no sistema TQS de dois modelos com configurações distintas, em que os resultados do coeficiente foram comparados com os obtidos através do processo P-. Os resultados evidenciam que a utilização de fatores de redução de rigidez mais refinados como estimativa da NLF proporcionou maior precisão na estimativa dos efeitos de 2ª ordem. Empregando os redutores de rigidez indicados pela NBR 6118 (2023) no modelo de 2 pavimentos, obteve-se 1,10, classificando a estrutura como de nós fixos. Entretanto, ao considerar os demais métodos de redução de rigidez, o coeficiente obtido foi de 1,13, reclassifcando a estrutura como de nós móveis. Logo, quando a estimativa dos efeitos da NLF é realizada de forma mais refinada, o coeficiente oferece uma estimativa adequada dos efeitos de 2ª ordem para as estruturas estudadas com menos de 4 pavimentos.
Determining Maximum Allowable Current of an RBS Using a Directed Graph Model and Greedy Algorithm
Authors: Xu Binghui , Hua Guangbin , Qian Cheng , Xia Quan , Sun Bo , Ren Yi , Wang Zili 
Published: January 2024

Reconfigurable battery systems (RBSs) provide a promising alternative to traditional battery systems due to their flexible and dynamically changeable topological structures that can be adapted to different battery charging and discharging strategies. A critical system parameter known as the maximum allowable current (MAC) is pivotal to RBS operation. This parameter is instrumental in maintaining the current of each individual battery within a safe range and serves as a guiding indicator for the system’s reconfiguration, ensuring its safety and reliability. This paper proposes a method for calculating the MAC of an arbitrary RBS using a greedy algorithm in conjunction with a directed graph model of the RBS. Using the shortest path of the battery, the greedy algorithm transforms the exhaustion of the switch states in the brute-force algorithm or variable search without utilizing structures in the heuristic algorithms in the combination of the shortest paths. The directed graph model, based on an equivalent circuit, provides a specific method for calculating the MAC of a given structure. The proposed method is validated using 2 previously published RBS structures and an additional one with a more complex structure. The results are the same as those from the brute-force algorithm, but the proposed method substantially improves the computational efficiency, being theoretically

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switches. Another advantage of the proposed method is its ability to calculate the MAC of RBSs with arbitrary structures and variable batteries, even in scenarios with random isolated batteries.
Multi objective optimization for house roof using artificial neural network model
Authors: Askar Ali Habeeb , Kovács Endre , Bolló Betti 
Published: January 2024

Roof models with low heat loss and low heating costs for buildings are crucial for reducing energy consumption and greenhouse gas emissions in cold regions. This study aimed to calculate the heat loss for various roof models with low heat loss, which are widely used in houses in Europe and other cold regions. We created 324 models for three types of roofs (light, medium, and heavy) with different materials and thicknesses using the HAP program. We then trained a neural network (ANN) to generate a mathematical function that can be used to calculate the optimal surface using a multi-objective genetic algorithm method. The resulting optimal roof design was simulated using the Ansys program on a January day. We compared the heat loss results for the optimal roof for HAP, ANN, and transient thermal analysis by Ansys, respectively, showing a close agreement among the methods.