bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social entrepreneurship: empirical evidence on its contribution to the realization of the sustainable development goals in Uganda
Authors: Turyakira Peter , Sendawula Kasimu , Nanyanzi Marion , Nantale Hanifah , Tamale Joyce Namirimo 
Published: February 2024

PurposeThis study explores the contribution of social entrepreneurship to the realization of the Sustainable Development Goals (SDGs) in Uganda.Design/methodology/approachWe employed a qualitative approach and a multiple-case design to engage 20 participants. Specifically, semi-structured interviews were conducted to gather the perceptions and views of the participants regarding the study phenomenon.FindingsStudy findings indicate that social entrepreneurs support a number of people and undertake activities that solve social, environmental and economic problems. However, environmental issues receive less focus when compared to other sustainability aspects. It is also evident that social entrepreneurs are financially constrained with limited managerial skills, undermining their potential to fulfill their social mission. Despite these challenges, social entrepreneurs have significantly contributed to the attainment of SDGs 1, 4, 5, 8 and 10 in Uganda.Originality/valueThis study contributes to the existing literature on social entrepreneurship and sustainable development. Specifically, it provides initial empirical evidence on the social entrepreneurial activities, the beneficiaries and challenges being addressed by social entrepreneurs and contribution to the attainment of the SDGs in Uganda.
Influences of entrepreneurship skills and universities on the promotion of entrepreneurial intentions of students; mediating role of business simulation games
Authors: Shabbir Muhammad Salman , Pallares-Venegas Ebetuel 
Published: February 2024

Purpose
Entrepreneurship has become a widely accepted concept in the past few decades due to its prominent role in economic activity and economic development of a nation. Promotion of entrepreneurship can be ensured with the help of entrepreneurship teaching and learning through higher education institutions. Similarly, entrepreneurship skills play a significant role in the promotion of students’ intentions to become entrepreneurs. This study aims to examine the role of universities and entrepreneurship skills on the entrepreneurial intentions of students.

Design/methodology/approach
Business simulation games is taken as mediator between university role and entrepreneurial intentions as well as entrepreneurship skills and entrepreneurial intentions. This research has used Smart PLS to perform a PLS-SEM technique with a data of 378 students from higher education institutions of Malaysia.

Findings
The results of data analysis show a positive role of universities and entrepreneurship skills in the promotion of student’s entrepreneurial intentions. Moreover, business simulation games positively mediates the relationship between dependent and independent variables.

Originality/value
Results of this research prove that entrepreneurial skills and university support have a significant part in the promotion of entrepreneurship intentions of students. As students use the electronic resources such as business simulation games, their skills, attitude and practical knowledge is positively enhanced and eventually it positively impacts the intention of students to become entrepreneurs. Therefore, it is believed that promotion of entrepreneurial skills in students via business simulation games and positive role of universities in promoting entrepreneurship will have a significant positive influence on the students’ entrepreneurial intentions.
Maintaining an Aberrant Practice in a Contradictory Environment: The Case of Doping in Professional Road Cycling
Authors: Forbes Tom , Fincham Robin 
Published: February 2024

AbstractSports doping is a practice that continues, despite hostile public opinion and counter‐efforts to close it down. In this paper we explore the maintenance of doping in the sport of professional road cycling. While studies of controversial practices find that they often benefit from levels of acceptance and even perceived value, we supplement such research by providing one of the few studies of practices that are subject to powerful social controls. In our case, the continual threat from anti‐doping organizations means that the maintenance and disruption of doping represents a kind of dialectical pair. We utilize and extend a model of types of institutional work that has advantages as an analytical tool, exploring the support required in this setting. Sustaining work was highly dynamic, relying on distinct groups within cycling teams to marshal organizational skills and cope with disruption, while repairing internal defences and concealing activities.
Effects of the protective and therapeutic effect of yogurt enriched with Citrus sinensis essential oil against ibuprofen‐induced gastric ulcer in elderly rats
Authors: Polat Zübeyde , Erol Zeki , Yalçın Halil , Özbek Mehmet , Karaca Harun 
Published: February 2024

AbstractThe aim of this study was to evaluate the effect of Citrus sinensis essential oil (EO) on the proximate composition of yogurt over a 28‐day shelf life and to investigate the therapeutic and prophylactic effects of functional yogurt on ibuprofen‐induced gastric ulcers in a rat model. It was observed that the yogurt group containing C. sinensis EO had higher acidity, total solids, and ash values. Histologic evaluation of the stomachs of rats with gastric ulcers revealed that rats fed with functional yogurt had fewer lesions compared to the control group. The treatment group had fewer lesions than the positive control (p > 0.05). Lesions in the glandular mucosa of the prophylactic group were significantly lower than those in the positive control group (p < 0.05). Yogurt with C. sinensis EO may be beneficial in reducing the severity of ulcers and improving overall health.
Dynamic structural equation models synthesize ecosystem dynamics constrained by ecological mechanisms
Authors: Thorson James T. , Andrews Alexander G. , Essington Timothy E. , Large Scott I. 
Published: February 2024

Abstract

Ecological analyses typically involve many interacting variables. Ecologists often specify lagged interactions in community dynamics (i.e. vector‐autoregressive models) or simultaneous interactions (e.g. structural equation models), but there is less familiarity with dynamic structural equation models (DSEM) that can include any simultaneous or lagged effect in multivariate time‐series analysis.

We propose a novel approach to parameter estimation for DSEM, which involves constructing a Gaussian Markov random field (GMRF) representing simultaneous and lagged path coefficients, and then fitting this as a generalized linear mixed model to missing and/or non‐normal data. We provide a new R‐package dsem, which extends the ‘arrow interface’ from path analysis to represent user‐specified lags when constructing the GMRF. We also outline how the resulting nonseparable precision matrix can generalize existing separable models, for example, for time‐series and species interactions in a vector‐autoregressive model.

We first demonstrate dsem by simulating a two‐species vector‐autoregressive model based on wolf–moose interactions on Isle Royale. We show that DSEM has improved precision when data are missing relative to a conventional dynamic linear model. We then demonstrate DSEM via two contrasting case studies. The first identifies a trophic cascade where decreased sunflower starfish has increased urchin and decreased kelp densities, while sea otters have a simultaneous positive effect on kelp in the California Current from 1999 to 2018. The second estimates how declining sea ice has decreased cold‐water habitats, driving a decreased density for fall copepod predation and inhibiting early‐life survival for Alaska pollock from 1963 to 2023.

We conclude that DSEM can be fitted efficiently as a GLMM involving missing data, while allowing users to specify both simultaneous and lagged effects in a time‐series structural model. DSEM then allows conceptual models (developed with stakeholder input or from ecological expertise) to be fitted to incomplete time series and provides a simple interface for granular control over the number of estimated time‐series parameters. Finally, computational methods are sufficiently simple that DSEM can be embedded as component within larger (e.g. integrated population) models. We therefore recommend greater exploration and performance testing for DSEM relative to familiar time‐series forecasting methods.
Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial
Authors: Brazauskas Ruta , Flynn Kathryn , Krishnan Amrita , Landau Heather , Giralt Sergio , Pasquini Marcelo C. , Stadtmauer Edward A. , D'Souza Anita 
Published: February 2024

SummaryAutologous haematopoietic cell transplantation (autoHCT) and continuous post‐transplant maintenance therapy are the standard of care in transplant‐eligible multiple myeloma (MM) patients. We sought to describe symptom burden and identify symptom clusters occurring in MM patients after autoHCT using data from the BMT CTN 0702 randomized controlled trial comparing the outcomes of three treatment interventions after an autoHCT in 758 MM patients. We analysed individual transplant‐related symptoms assessed via the FACT‐BMT questionnaire at enrolment and annually for 4‐year post‐autoHCT. We also described the effect the individual symptoms and symptom clusters have on quality of life (QoL). We identified three stable symptom clusters: malaise symptom cluster (lack of energy, feeling ill, having pain, experiencing nausea, loss of appetite), physical symptom cluster (having skin problems, tremors, worsening eyesight, change in taste, shortness of breath, frequent colds) and emotional symptom cluster (feeling sad, being nervous, experiencing sleep problems). Malaise and emotional symptom clusters have a greater impact on QoL than the physical symptoms cluster. Identifying these symptoms warrant additional support in terms of psychosocial support, in addition to treatment of the physical symptoms themselves.
Network pharmacology and in vitro experiments reveal sophoridine‐induced apoptosis and G1 phase arrest via ROS‐dependent PI3K/Akt/FoxO3a pathway activation in human bladder cancer cells
Authors: Su Yao , Chen Lin , Yang Jin 
Published: February 2024

AbstractBladder cancer (BLCA), a common primary malignancy, exhibits resistance to conventional chemotherapeutic agents. Sophoridine (SR) is a quinoline alkaloid derived from the traditional Chinese herb Sophora alopecuroides L., which belongs to the legume family Sophoraceae. SR is reported to exert growth‐inhibitory effects against several cancers. However, the mechanisms underlying the growth‐inhibitory effects of SR on BLCA have not been elucidated. This study performed molecular and cellular experiments to verify the growth‐inhibitory effects of SR on BLCA and the underlying mechanisms. SR inhibited cell proliferation and promoted apoptosis and G1‐phase arrest through the PI3K/AKT/FoxO3a signaling pathway. More interestingly, the effects of SR can be attributed to the accumulation of reactive oxygen species (ROS) in vivo. ROS may be the upstream factor of this pathway. Additionally, SR inhibited the migration and invasion of BLCA cells in a concentration‐dependent or time‐dependent manner. This is the first study to demonstrate the ROS‐dependent PI3K/AKT/FoxO3a pathway‐mediated anticancer effect of SR and the anticancer mechanism of SR in BLCA. The correlation between SR‐induced ROS‐dependent cell proliferation inhibition, apoptosis, cell cycle arrest, and PI3K/AKT/FoxO3a suggests that SR is a promising novel therapeutic for BLCA.
Gender differences in retinal diseases: A review
Authors: Tillmann Anne , Ceklic Lala , Dysli Chantal , Munk Marion R. 
Published: February 2024

AbstractGender medicine is a medical specialty that addresses gender differences in health and disease. Traditionally, medical research and clinical practice have often been focused on male subjects and patients. As a result, gender differences in medicine have been overlooked. Gender medicine considers the biological, psychological, and social differences between the genders and how these differences affect the development, diagnosis, treatment, and prevention of disease. For ophthalmological diseases epidemiological differences are known. However, there are not yet any gender‐based ophthalmic treatment approaches for women and men. This review provides an overview of gender differences in retinal diseases. It is intended to make ophthalmologists, especially retinologists, more sensitive to the topic of gender medicine. The goal is to enhance comprehension of these aspects by highlighting fundamental gender differences. Integrating gender medicine into ophthalmological practice helps promote personalized and gender‐responsive health care and makes medical research more accurate and relevant to the entire population.
Sensitization to textile dyes in Spain: Epidemiological situation (2019–2022)
Authors: Hernández Fernández Carlos Pelayo , Borrego Leopoldo , Giménez Arnau Ana María , Zaragoza Ninet Violeta , Sanz Sánchez Tatiana , Miquel Miquel Francisco Javier , González Pérez Ricardo , Silvestre Salvador Juan Francisco , Córdoba Guijarro Susana , Carrascosa Carrillo José Manuel , Gatica Ortega María Elena , Ruiz González Inmaculada , Mercader García Pedro , Tous Romero Fátima , Serra Baldrich Esther , Pastor‐Nieto María Antonia , Rodríguez Serna Mercedes , Sánchez Pérez Javier , Sánchez Gilo Araceli , Melé Ninot Gemma , Sánchez‐Pedreño Guillén Paloma , de Vega Martínez Marina , Descalzo Miguel Ángel Gallego , Doval Ignacio García 
Published: February 2024

AbstractBackgroundCurrent frequency and features for positivity to textile dye mix (TDM) in Spain are unknown.ObjectivesTo study the frequency, clinical features and simultaneous positivity between TDM, para‐phenylenediamine (PPD) and specific disperse dyes.Materials and MethodsWe analysed all consecutive patients patch‐tested with TDM from the Spanish Contact Dermatitis Registry (REIDAC), from 1 January 2019 to 31 December 2022. Within this group, we studied all selected patients patch‐tested with a textile dye series.ResultsOut of 6128 patients analysed, 3.3% were positive to the TDM and in 34% of them, the sensitization was considered currently relevant. TDM positivity was associated with working as a hairdresser/beautician and scalp, neck/trunk and arm/forearm dermatitis. From TDM‐positive patients, 57% were positive to PPD. One hundred and sixty‐four patients were patch‐tested with the textile dye series. Disperse Orange 3 was the most frequent positive dye (16%). One of every six cases positive to any dye from the textile dye series would have been missed if patch‐tested with the TDM alone.ConclusionsPositivity to TDM is common in Spain and often associated with PPD sensitization. TDM is a valuable marker of disperse dyes allergy that should be part of the Spanish and European standard series.
Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta‐analysis
Authors: Boivin‐Proulx Laurie‐Anne , Marquis‐Gravel Guillaume , Rousseau‐Saine Nicolas , Harel François , Jolicoeur E. Marc , Pelletier‐Galarneau Matthieu 
Published: February 2024

AbstractBackgroundGiven the limited access to invasive vasospastic reactivity testing in Western Countries, there is a need to further develop alternative non‐invasive diagnostic methods for vasospastic angina (VSA). Hyperventilation testing (HVT) is defined as a class IIa recommendation to diagnose VSA by the Japanese Society of Cardiology.MethodsIn this systematic review and meta‐analysis reported according to the PRISMA statement, we review the mechanisms, methods, modalities and diagnostic accuracy of non‐invasive HVT for the diagnostic of VSA.ResultsA total of 106 articles published between 1980 and 2022 about VSA and HVT were included in the systematic review, among which 16 were included in the meta‐analysis for diagnostic accuracy. Twelve electrocardiogram‐HVT studies including 804 patients showed a pooled sensitivity of 54% (95% confidence intervals [CI]; 30%–76%) and a pooled specificity of 99% (95% CI; 88%–100%). Four transthoracic echocardiography‐HVT studies including 197 patients revealed a pooled sensitivity of 90% (95% CI; 82%–94%) and a pooled specificity of 98% (95% CI; 86%–100%). Six myocardial perfusion imaging‐HVT studies including 112 patients yielded a pooled sensitivity of 95% (95% CI; 63%–100%) and a pooled specificity of 78% (95% CI; 19%–98%). Non‐invasive HVT resulted in a low rate of adverse events, ventricular arrhythmias being the most frequently reported, and were resolved with the administration of nitroglycerin.ConclusionsNon‐invasive HVT offers a safe alternative with high diagnostic accuracy to diagnose VSA in patients with otherwise undiagnosed causes of chest pain.
Growth at risk from climate change
Authors: Kiley Michael T. 
Published: February 2024

AbstractHow will climate change affect risks to economic activity? Research on climate impacts has tended to focus on effects on the average level of economic growth. I examine whether climate change may make severe contractions in economic activity more likely using quantile regressions linking growth to temperature. The effects of temperature on downside risks to economic growth are large and robust across specifications. These results suggest the growth at risk from climate change is large—climate change may make economic contractions more likely and severe and thereby significantly impact economic and financial stability and welfare.
A global meta‐analysis of yield‐scaled N2O emissions and its mitigation efforts for maize, wheat, and rice
Authors: Yao Zhisheng , Guo Haojie , Wang Yan , Zhan Yang , Zhang Tianli , Wang Rui , Zheng Xunhua , Butterbach‐Bahl Klaus 
Published: February 2024

AbstractMaintaining or even increasing crop yields while reducing nitrous oxide (N2O) emissions is necessary to reconcile food security and climate change, while the metric of yield‐scaled N2O emission (i.e., N2O emissions per unit of crop yield) is at present poorly understood. Here we conducted a global meta‐analysis with more than 6000 observations to explore the variation patterns and controlling factors of yield‐scaled N2O emissions for maize, wheat and rice and associated potential mitigation options. Our results showed that the average yield‐scaled N2O emissions across all available data followed the order wheat (322 g N Mg−1, with the 95% confidence interval [CI]: 301–346) > maize (211 g N Mg−1, CI: 198–225) > rice (153 g N Mg−1, CI: 144–163). Yield‐scaled N2O emissions for individual crops were generally higher in tropical or subtropical zones than in temperate zones, and also showed a trend towards lower intensities from low to high latitudes. This global variation was better explained by climatic and edaphic factors than by N fertilizer management, while their combined effect predicted more than 70% of the variance. Furthermore, our analysis showed a significant decrease in yield‐scaled N2O emissions with increasing N use efficiency or in N2O emissions for production systems with cereal yields >10 Mg ha−1 (maize), 6.6 Mg ha−1 (wheat) or 6.8 Mg ha−1 (rice), respectively. This highlights that N use efficiency indicators can be used as valuable proxies for reconciling trade‐offs between crop production and N2O mitigation. For all three major staple crops, reducing N fertilization by up to 30%, optimizing the timing and placement of fertilizer application or using enhanced‐efficiency N fertilizers significantly reduced yield‐scaled N2O emissions at similar or even higher cereal yields. Our data‐driven assessment provides some key guidance for developing effective and targeted mitigation and adaptation strategies for the sustainable intensification of cereal production.
Morphological analysis of patellofemoral joint in haemophilic arthropathy: A case‐control study
Authors: Vahabi Arman , Biçer Elcil Kaya , Kayıkçı Kayahan , Şahin Fahri , Kavaklı Kaan , Tamsel İpek , Aydoğdu Semih 
Published: February 2024

AbstractIntroductionKnees affected by haemophilic arthropathy exhibit distinct differences in both bone morphology and soft tissue behaviour. This study aims to analyse the morphological characteristics of the distal femur and patellofemoral joint in patients with haemophilia in comparison to normal healthy population.Material and MethodsStudy was conducted as pair‐matched case‐control study with 43 individuals in both the haemophilia group and the control group. Patellar luxation, patellar tilt (PT), length of the patella in both axis (pAP, pML), depth and angle of trochlear sulcus (SD, SA), lateral trochlear inclination (LTI), medial and lateral femoral facet length (mFL, LFL), intercondylar depth (ID), transepicondylar axis (TEA) and lateral condyle length (LCL) were assessed on knee MRI. Correlation between Pettersson score and measured variables were also analysed.ResultsPT was medial sided in 10 (23.2%) cases in haemophilic group. Mean values of pAP, pML, PT were significantly lower in haemophilia group (p < .001, p: .007, p = .001 respectively). There were no significant changes in SA (p = .628), SD (p = .340), LTI (p = .685), LFL (p = .241) and MFC‐LFC (p = .770) whilst mFL was significantly longer in haemophilia group (p = .009). ID (p < .001), TEA (p = .007) and LCL (p = .001) were all shorter in haemophilia group. Pettersson score was inversely correlated with pAP, pML, ID, TEA, LCL, pML/SA and ID/LCL.ConclusionMorphological changes in haemophilic arthropathy involve a smaller and medially‐tilted patella, narrowed lateral condyle and transepicondylar axis, combined with reduced intercondylar depth. These alterations must keep in mind especially in pre‐ and intraoperative assessments for arthroplasty procedures.
Enhancement of oxidative stability of polyunsaturated fatty acid‐rich fish oil: microencapsulation using chitosan‐whey protein complex and betalain
Authors: Kalladathvalappil Venugopalan Vishnu , Ramadevi Gopakumar Lekshmi , Kumaran Kizhakkeppurath Ajeeshkumar , Sekhar Chatterjee Niladri , Soman Vishnuja , Mohamed Hatha Ammanamveetil Abdulla , Benjakul Soottawat , Mathew Suseela 
Published: February 2024

SummaryPolyunsaturated fatty acids (PUFAs), which are abundant in fish oil, easily oxidise. Therefore, stabilisation is necessary, preferably through encapsulation and the addition of antioxidants. This research looked on multiple emulsification for PUFA‐rich fish oil by utilising a wall material (whey protein and chitosan) and an antioxidant (betalain) combination. Spray‐dried, microparticles filled with PUFA were successfully created (80% yield) and characterised. It was determined that the emulsion droplet size was 0.917 μm. Good oxidative stability was observed after 4 weeks of storage, as evidenced by a moderate (4%) drop in EPA and DHA content and a low peroxide value (PV) of 4.8 ± 0.23 meq/kg oil in microparticles. Microencapsulation of PUFA‐rich fish oil was successfully accomplished using multiple emulsion technology, as evidenced by encapsulation efficiency values of 87.73 ± 0.21% and loading efficiency values of 67 ± 0.11%. These results suggest that structurally stabilised healthful lipids could be added to foods using these innovative emulsions, which provide greater stability and versatility for a wide variety of uses.