bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational-Related Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-analysis
Authors: DeStefano Vincent , Shah Darshi , Shah Veer , Seyyedsalehi Monireh Sadat , Bonetti Mattia , Boffetta Paolo 
Published: January 2024

Abstract
Purpose
Benzene is a recognized carcinogen; however, its association with breast cancer is not well established. Hence, a meta-analysis of cohort and case-control studies was performed to determine the association between occupational benzene exposure and the risk of breast cancer.
Methods
A systematic literature review identified 7221 publications from which 21 cohort and case-control studies were retained and evaluated using meta-analyses (fixed effects model). PRISMA guidelines were followed. Our protocol was registered in the PROSPERO database (Registration No. 379720). Study quality was assessed using a modified Newcastle-Ottawa scale (NOS).
Results
The summary RR for ever-benzene exposure was 1.08 (95% CI = 1.02–1.14, I2 = 43.6%, n = 21 risk estimates); corresponding RR for cancer incidence and mortality were 1.08 (95% CI = 1.02–1.14, I2 = 58.6%, n = 15) and 1.09 (95% CI = 0.87–1.38, I2 < 0.001%, n = 9), respectively. These main results were confirmed in sub-analyses by geography, industry, publication year, and levels of exposure. No heterogeneity was detected amongst geographical regions (p-het = 0.19) or industry of employment (p-het = 0.05). However, heterogeneity was detected for sex (p-het = 0.002), publication year (p-het < 0.001), study design (p-het < 0.001), and study quality (p-het < 0.001). Publication bias was detected (p = 0.04).
Conclusions
Our meta-analysis identified an association between occupational benzene exposure and risk of breast cancer. No heterogeneity was detected for occupational cohorts, geographical regions, and durations of exposure. These findings, and an inability to exclude residual confounding, together with publication bias, prevent conclusions of causality.
Current-to-final Rank Differences in 24-hour Ultra Cycling: Critical Event Phases, and the Impacts of Team Size and Performance Levels
Authors: Dindorf Carlo , Dully Jonas , Maurer Lukas , Becker Stephan , Simon Steven , Bartaguiz Eva , Fröhlich Michael 
Published: January 2024

Abstract

This study investigates the intricate dynamics of rank-order stability by examining the current-to-final rank difference (CFRD) during 24-hour cycling races, especially how different team sizes and performance levels contribute to the temporal trends in CFRD. A comprehensive dataset covering five consecutive years (2019–2023) of a 24-hour cycling race on a 17.9 km repetitive driven road track, encompassing diverse team sizes (solo rider, or teams of 4 and 10), is used. The results indicate significant interactions between time, team size, and performance, with CFRD consistently decreasing across team sizes and performance levels over the race duration. Temporal analysis unveils critical phases with pronounced changes in CFRD, providing nuanced insights into the evolving dynamics of 24-hour races. Notable distinctions emerge between team sizes, with solo riders exhibiting unique patterns. High-performance teams consistently maintain a lower CFRD, exhibiting more predictable outcomes over the race duration. Overall, this study advances our understanding of endurance team cycling, and offers valuable insights for strategic decision making and race optimization.
Underground Space-Subsidence and Economic Impact Planning Model in Shanghai: Cause-Effect and Spatiotemporal Regression Analyses for Year 1960-2020
Authors: Hishammnuddin Muhammad Akmal Hakim bin , Wang Jianxiu , Ismail Muhammad Azizol , Yang Tianliang , Huang Xinlei , Abidin Hasanuddin Zainal , Ho Chin Siong , Kanniah Kasturi Devi , Wong Keng Yinn 
Published: January 2024

Abstract

Shanghai is continuously threatened with land subsidence with impact on its built environment e.g. building, land, properties, infrastructure and socio-economic activities. This research studies the mutiregression and spatiotemporal of the identified causing factors; surface load, groundwater-induced, socio-economic growth, underground space development (UUS), climate change and presents the relations of the multifactor in 1960–2020. Data are collected secondarily from open sourced databases. Results determine rhe causing factors with high correlation coefficients > 0.90 R squared values are; UUS development induced-subsidence, tunneling leakage and weak spatial modelling. Economic impact factors include; building price, reconstruction area, arable land, GDP by district and metro tunnel settlement. Spatiotemporal patterns depict the population and land subsidence is growing in spatial autocorrelation with the ratio of 0.89:1.00 indirect-negative economic impact from Urban City Centre, Pudong New Area, Minhang, Baoshan and Songjiang districts. These results can be referred as preparation for further adaptive and resilient scenario spatial planning and modelling.
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Authors: Moreaux Jérôme , Maiorano Domenico , Pourquier Philippe , Yang Wen-Chin , Lin Yea-Lih , Pasero Philippe , Coquel Flavie 
Published: January 2024

Abstract

Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or to inhibit checkpoint kinases involved in the DNA damage response (DDR). Thus far, treatments that combine these two strategies have shown promise but also have severe adverse effects. To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the same plant, Psoralea corylifolia, that synergistically inhibit proliferation of cancer cells. Bakuchiol inhibited DNA replication in human cells and in Xenopus egg extracts, and activated the checkpoint kinase CHK1, likely by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand breaks (DSBs) repair by inhibiting the checkpoint kinase CHK2 and the resection of DNA ends. The combination of isobavachalcone and bakuchiol synergistically inhibited cancer cell proliferation in vitro. Importantly, it also prevented tumor development in xenografted mice at the concentration ratio naturally found in plant extracts. The synergistic effect of inhibiting DNA replication and resection identifies a novel vulnerability of cancer cells that might be exploited by using clinically approved inhibitors of these mechanisms in novel combination therapies.
Regulation of miR-17-3p on K562 cell proliferation and erythroid differentiation as well as γ-globin expression in patients with β-thalassemiar
Authors: Zhang Siwen , Chenï Meihuan , Zheng Junhao , Zhang Yanhong , Lv Aixiang , Li Jingmin , Cao Hua , Xu Liangpu , Huang Hailong 
Published: January 2024

Abstract
Large numbers of microRNAs (miRNAs) have been found to be dysregulated in β-thalassemia (β-thal), but their roles in β-thal are poorly reported. The purpose of this study was to investigate the clinical significance of miR-17-3p in β-thal, and to elucidate its regulatory effect on K562 cell proliferation and erythroid differentiation as well as γ-globin expression.17 patients with β-thal intermedia and major and 17 healthy controls were selected and peripheral blood samples were collected from the participants. The expression of miR-17-3p and B cell lymphoma 11A (BCL11A) were detected by qRT-PCR and Western blotting. The regulation of miR-17-3p on BCL11A was evaluated by luciferase reporter gene assay. Cell proliferation, cell cycle, cell apoptosis and erythroid differentiation was assessed CCK-8 and Flow cytometry.The data demonstrated that upregulated miR-17-3p expression is associated with patients with β-thal intermedia and major. Although miR-17-3p has no significant effect on cell proliferation and erythroid differentiation, miR-17-3p promotes γ-globin expression by targeting BCL11A, suggesting that miR-17-3p may be an promising miRNA for the treatment of β-thal.
In-vivo cerebral artery pulsation assessment with Dynamic Computed Tomography Angiography
Authors: Stam Lotte B. , Linden Sabine M. L. , Aquarius René , Hering Alessa , Oostveen Luuk J. , Meijer Frederick J.A. , Boogaarts Hieronymus D. 
Published: January 2024

Abstract
Four-Dimensional Computed Tomography Angiography (4D CTA) seems a promising technique for capturing vessel motion of cerebral arteries, which may help to assess pathological conditions such as intracranial aneurysms. The goal of our current study is to capture the lumen diameter of cerebral arteries during three subsequent cardiac cycles with 4D CTA and to assess vessel motion, anticipating consistent expansion patterns within each cardiac cycle. Eighteen adult patients with unruptured and untreated intracranial aneurysms were recruited at Radboud University Medical Center. Three cardiac cycles were captured, on a wide detector CT system, using ECG-gated 4D CTA. To reduce the impact of small head movements during the acquisition, a rigid-body registration was employed. Three 10 mm segments of cerebral arteries were selected. The total deformation of the vessel lumen was calculated using a deformable registration algorithm and was used as a substitute measure for vessel motion. No pulsations could be registered, which was probably caused by pulsation motion below threshold of detection in combination with insufficient Signal-to-Noise Ratio. Further studies need to investigate if large intracranial structures can be evaluated and if using a novel scanner with a high spatial resolution would result in reproducible measurements of arteries this size.
Impact of Pneumothorax on Mortality, Morbidity, and Hospital Resource Utilization in COVID-19 Patients: A Propensity Matched Analysis of Nationwide Inpatient Sample Database
Authors: Nasrullah Adeel , Quazi Mohammed A. , Virk Shiza , Niranjan Sitara , Butt Muhammad Ali , Shakir Muhammad Hassan , Sohail Amir Humza , Bilal Muhammad Ibraiz , Muzammil Taimur , DiSilvio Briana , Sheikh Abu Baker , Cheema Tariq 
Published: January 2024

Abstract

Background Spontaneous pneumothorax (PTX) is more prevalent among COVID-19 patients than other critically ill patients, but studies on this are limited. This study compared clinical characteristics and in-hospital outcomes among COVID-19 patients with concomitant PTX to provide insight into how PTX affects health care utilization and complications, which informs clinical decisions and healthcare resource allocation.Methods The 2020 Nationwide Inpatient Sample was used analyze patient demographics and outcomes, including age, race, sex, insurance status, median income, length of hospital stay, mortality rate, hospitalization costs, comorbidities, mechanical ventilation, and vasopressor support. Propensity score matching was employed for additional analysis.Results Among 1,572,815 COVID-19 patients, 1.41% had PTX. These patients incurred significantly higher hospitalization costs ($435,508 vs. $96,668, p < 0.001) and longer stays (23.6 days vs. 8.6 days, p < 0.001). In-hospital mortality was substantially elevated for PTX patients (65.8% vs. 14.4%, p < 0.001), with an adjusted odds ratio of 14.3 (95% CI 12.7–16.2). Additionally, these patients were more likely to require vasopressors (16.6% vs. 3.3%), mechanical circulatory support (3.5% vs. 0.3%), hemodialysis (16.6% vs. 5.6%), invasive mechanical ventilation (76.9% vs. 15.1%), non-invasive mechanical ventilation (19.1% vs. 5.8%), tracheostomy (13.3% vs. 1.1%), and chest tube placement (59.8% vs. 0.8%).Conclusions Our findings highlight the severe impact of PTX on COVID-19 patients, characterized by higher mortality, more complications, and increased resource utilization. Also, being Hispanic, male, or obese increased the risk of developing concomitant PTX with COVID-19.
Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments
Authors: Sivadasan Durgaramani , Venkatesan Krishnaraju , Mohamed Jamal Moideen Muthu , Alqahtani Saud , Asiri Yahya I. , Faisal Mennatullah M. , Ibrahim Adel Ehab , Menaa Farid , Deeb Sami El 
Published: January 2024

Abstract
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) in gel for topical delivery. Nine different formulations of emulsion were prepared by solvent evaporation method with polyvinyl alcohol (PVA), ethyl cellulose (EC), and dichloromethane (DCM). Based on 32 Full Factorial Design (FFD), optimization was carried out by varying the concentration of LOR:EC ratio and stirring rate. The preparations were subjected for the evaluation of particle size (PS), in vitro release, zeta potential (ZP) and entrapment efficiency (EE). The results revealed that the NS dispersion was nanosized with sustained release profiles and significant PS. The optimized formulation was formulated and incorporated into carbopol 934P hydrogel. The formulation was then examined to surface morphological characterizations using scanning electron microscopy (SEM) which depicted spherical NS. Stability studies, undertaken for 2 months at 40 ± 2 ℃ and 75 ± 5% RH, concluded to the stability of the formulation. The formulation did not cause skin irritation. Therefore, the prepared NS hydrogel proved to be a promising applicant for LoR as a novel drug delivery system (NDDS) for safe, sustained and controlled topical application.
5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis
Authors: Meevassana Jiraroch , Varophas Shananya , Prabsattru Piyawan , Kamolratanakul Supitcha , Ruangritchankul Komkrit , Kitkumthorn Nakarin 
Published: January 2024

Abstract
There is a correlation between DNA methylation and the diseased stage and poor survival. Formation of 5-methylcytosine is one of the epigenetic alterations that has received the most attention from researchers (5-mC). Staining with 5-mC immunohistochemistry was used to examine pathological samples taken from individuals diagnosed with cutaneous melanoma. Between Breslow levels 2 and 4, there was a significant difference in the H-score of 5-mC expression (p = 0.046). A significant reduction in 5-mC expression H-scores was seen in patients who were diagnosed with ulcers (p = 0.039). It was shown that patients with low 5-mC had a significantly worse overall survival rate (p = 0.027).
Effects of Decision Making and Impulsivity on the addictive Characteristics of Non-Suicidal Self-Injurious Behavior in Adolescents with Depressive Disorders
Authors: Jiang Yulian , Yu Hang , Zheng Quanming , Zhu Yuqiong , Qin Qiyue , Zhang Jun , Cui Ruomeng , Wu Wei , Wu Chengcong , Li Tiancheng , Jiao Dongliang , Wang Wenjuan , Ji Chenguang 
Published: January 2024

Abstract

Objective
Non-suicidal self-injurious (NSSI) behaviors pose a significant threat to the physical and psychological well-being of adolescents. This study investigated the addictive nature of NSSI behaviors and their association with impulsivity and decision-making, aiming to provide evidence-based insights for the development of multiple effective treatment interventions for adolescents with depressive disorders exhibiting addictive characteristics in their NSSI behaviors.
Methods
A total of 126 adolescent outpatients and inpatients diagnosed with depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria were selected and categorized into three groups: depression without NSSI (n = 42), depression with NSSI without addictive characteristics (n = 44), and depression with NSSI and addictive characteristics (n = 40). The present study employed the Hamilton Depression Scale (HAMD-24), Chinese Revised Barratt Impulsiveness Scale Version 11 (BIS-11), Ottawa Self-Injury Inventory (OSI), and the Adolescent Non-Suicidal Self-Injury Questionnaire (ANSSIQ). Cognitive decision-making abilities were assessed using the Iowa Gambling Task (IGT).
Results
There were no significant differences observed in blocks 1 and 2 of the IGT among the three groups. However, the depression with NSSI addictive characteristics group exhibited significantly lower net scores in blocks 3, 4, and 5 of the IGT compared to both the depression without NSSI group and the depression with NSSI non-addictive characteristics group. The addictive characteristics of NSSI behaviors were positively correlated with the severity of NSSI behaviors, depression, and cognitive impulsiveness, and negatively correlated with the total net score of the IGT. In the mediation model, depression played a partial mediating role between cognitive impulsiveness and NSSI behavioral addiction characteristics.
Conclusion
Adolescents with depressive disorders exhibiting addictive NSSI behaviors demonstrate heightened cognitive impulsivity and exhibit poorer decision-making when presented with choices. Timely modulation of depressive symptoms can be effective in reducing the occurrence of the addictive characteristics of NSSI behaviors.
Impacts of land use type on sampling methods for human and simian malaria vectors
Authors: de Straat Bram van , Kurniawan Ahadi , Sebayang Boni , Garjito Triwibowo Ambar , Lubis Inke Nadia D. , Russell Tanya L. , Burkot Thomas R. 
Published: January 2024

Abstract

Background
Malaria transmission to humans is increasing in complexity in Indonesia with simian malaria cases in humans increasing as human malaria incidence diminishes. Reliable, epidemiologically relevant, logistically feasible, and cost-effective collection methods are needed to define the transmission risk to humans and the efficacy of vector control for both simian and human malarias. Alternative and/or complementary representative mosquito sampling methods to the labour-intensive human landing collections (HLC) and animal-baited tent traps (ABT) currently used in Indonesia are needed.
Methods
Carbon dioxide gas from a compressed cylinder and from yeast/sugar fermentation were used as lures in Passive Box, CDC Light and BG Sentinel 2 mosquito traps and compared in Latin square trials to human landing catches (HLCs) and animal baited traps (ABTs) for sensitivity and specificity for anopheline vectors across three land use types (oil palm plantation, mixed-crop agricultural area and village) in North Sumatra.
Results
The ABT with cow as bait was the most sensitive sampling method for all anopheline species in a direct comparison to HLC and the BG-Sentinel 2 trap in North Sumatra. The Passive Box and CDC Light traps were not sensitive for anophelines regardless of the CO2 source. The HLC showed high specificity for members of the An. dirus complex, and also captured An. kochi, An. barbirostris complex, and An. maculatus Group mosquitoes.
Is pancreaticoduodenectomy justified for metastatic melanoma to the ampulla of Vater?
Authors: Hsi Chieh-Ning , Wang Shin-E , Shyr Bor-Shiuan , Chen Shih-Chin , Shyr Yi-Ming , Shyr Bor-Uei 
Published: January 2024

Abstract
Background
Metastatic melanoma to the ampulla of Vater is rare. The purpose of this study is to summarize the characteristics and outcomes of metastatic melanoma to the ampulla of Vater, and to highlight the impact of surgery on the prognosis of patients with metastatic melanoma.
Methods
The pooled data from a case encountered at our institution and all the sporadic cases published on PubMed and MEDLINE from 1996 to 2023 were included for analysis.
Results
A total of 14 cases of metastatic melanoma to the ampulla of Vater were recruited. Seventy-three percent of the primary melanomas were cutaneous type, and 27% mucosal type. The most common symptom was jaundice (86%). The size of metastatic melanoma to ampulla ranged from 1.5 cm to 8 cm, with a median of 2.75 cm. Concomitant metastasis to other organs occurred in 82% at the diagnosis of this tumor, most commonly to the brain, lungs, and liver (36% each, respectively). Among all the reported cases, pancreaticoduodenectomy was performed in five patients. The overall 1-year survival rate was 27.3%, with a median of 4 months. Wide excision of the primary lesion and chemotherapy significantly improve the survival rate (p = 0.048). There is a trend toward improved survival in those undergoing pancreaticoduodenectomy followed by chemotherapy.
Conclusions
Given the availability of effective systemic therapy, metastatic melanoma to the ampulla of Vater is not necessarily to preclude a major surgery.
Effects of different land use patterns on soil aggregate organic carbon in Hainan island, South China
Authors: Huo Yanru , wang junguang , zhao zhizhong 
Published: January 2024

Abstract

The study explored the effects of different land use patterns on soil aggregate organic carbon in tropical island, and to provide scientific basis for further understanding in the characteristics and rules of soil carbon cycle in tropical island.Soil samples were collected from 0 to 30cm soil profile in farmland, vegetable fields, derelict land and economic woodland in the study area. Combination of dry and wet screening was adopted as the method to separate aggregates, and soil organic carbon and aggregate organic carbon content was determined by method of external heating by using potassium dichromate, to analyze the characteristics and variation rules of organic carbon in soil aggregates in 0-30cm soil profile. (1)In general, the SOC content of different land use patterns shows a following trend: farmland > vegetable fields > economic woodland > derelict land. (2) In 0-30cm soil profile, regarding to farmland, soil aggregate content increases as the particle size of soil aggregate decreases. In vegetable fields, the content is maximum when the particle size of aggregate is between 1mm and 2mm. In economic woodland, the content reduces as the particle size decreases. It suggests that the composition proportion of soil aggregate particle size is different greatly under different land use patterns. (3) Under different land use patterns, the SOC content of soil aggregates with different particle sizes also vary. Except farmland, the SOC content of soil aggregates under other land use patterns shows an increasing trend with the decrease of soil aggregate particle size. Under different land use patterns, the SOC content in soil aggregates with different particle sizes is different. The smaller the particle size is, the better the accumulation of SOC is. Soil aggregate organic carbon content is significantly different under different land use patterns. Farmland and vegetable fields are in favor of the accumulation of soil aggregate organic carbon.