bluuebunny/crossref_metadata_2025_split huggingface dataset:
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice
Authors: Yoshimura Naoto , Kariya Ryusho , Shimada Masaki , Tateyama Makoto , Matsunaga Hideto , Shibata Yuto , Tanimura Shuntaro , Takata Kosei , Arima Takahiro , Kawakami Junki , Maeda Kazuya , Fukuma Yuko , Uragami Masaru , Ideo Katsumasa , Sugimoto Kazuki , Yonemitsu Ryuji , Matsushita Kozo , Hisanaga Satoshi , Yugami Masaki , Uehara Yusuke , Masuda Tetsuro , Nakamura Takayuki , Tokunaga Takuya , Karasugi Tatsuki , Sueyoshi Takanao , Sato Hiro , Iwakura Yoichiro , Araki Kimi , Kobayashi Eisuke , Okada Seiji , Miyamoto Takeshi 
Published: December 2023

AbstractOsteosarcoma is rare but is the most common bone tumor. Diagnostic tools such as magnetic resonance imaging development of chemotherapeutic agents have increased the survival rate in osteosarcoma patients, although 5-year survival has plateaued at 70%. Thus, development of new treatment approaches is needed. Here, we report that IL-17, a proinflammatory cytokine, increases osteosarcoma mortality in a mouse model with AX osteosarcoma cells. AX cell transplantation into wild-type mice resulted in 100% mortality due to ectopic ossification and multi-organ metastasis. However, AX cell transplantation into IL-17-deficient mice significantly prolonged survival relative to controls. CD4-positive cells adjacent to osteosarcoma cells express IL-17, while osteosarcoma cells express the IL-17 receptor IL-17RA. Although AX cells can undergo osteoblast differentiation, as can patient osteosarcoma cells, IL-17 significantly inhibited that differentiation, indicating that IL-17 maintains AX cells in the undifferentiated state seen in malignant tumors. By contrast, IL-17RA-deficient mice transplanted with AX cells showed survival comparable to wild-type mice transplanted with AX cells. Biopsy specimens collected from osteosarcoma patients showed higher expression of IL-17RA compared to IL-17. These findings suggest that IL-17 is essential to maintain osteosarcoma cells in an undifferentiated state and could be a therapeutic target for suppressing tumorigenesis.
Systematic reduction of hyperspectral images for high-throughput plastic characterization
Authors: Ghaffari Mahdiyeh , Lukkien Mickey C. J. , Omidikia Nematollah , Tinnevelt Gerjen H. , van Eijk Marcel C. P. , Podchezertsev Stanislav , Jansen Jeroen J. 
Published: December 2023

AbstractHyperspectral Imaging (HSI) combines microscopy and spectroscopy to assess the spatial distribution of spectroscopically active compounds in objects, and has diverse applications in food quality control, pharmaceutical processes, and waste sorting. However, due to the large size of HSI datasets, it can be challenging to analyze and store them within a reasonable digital infrastructure, especially in waste sorting where speed and data storage resources are limited. Additionally, as with most spectroscopic data, there is significant redundancy, making pixel and variable selection crucial for retaining chemical information. Recent high-tech developments in chemometrics enable automated and evidence-based data reduction, which can substantially enhance the speed and performance of Non-Negative Matrix Factorization (NMF), a widely used algorithm for chemical resolution of HSI data. By recovering the pure contribution maps and spectral profiles of distributed compounds, NMF can provide evidence-based sorting decisions for efficient waste management. To improve the quality and efficiency of data analysis on hyperspectral imaging (HSI) data, we apply a convex-hull method to select essential pixels and wavelengths and remove uninformative and redundant information. This process minimizes computational strain and effectively eliminates highly mixed pixels. By reducing data redundancy, data investigation and analysis become more straightforward, as demonstrated in both simulated and real HSI data for plastic sorting.
Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization
Authors: Tang Chao , Ma Yayu , Lei Xiaoyang , Ding Yaqi , Yang Sushuang , He Dian 
Published: December 2023

AbstractThis study aimed to investigate the relationship between hypertension and Alzheimer’s disease (AD) and demonstrate the key role of stroke in this relationship using mediating Mendelian randomization. AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important role in the causal relationship between hypertension and AD. Specifically, the mediated indirect effect value for stroke obtained using multivariate mediated MR analysis was 54.9%. This implies that approximately 55% of the risk of AD owing to hypertension can be attributed to stroke. The results suggest that the increased risk of AD owing to hypertension is mediated through stroke. The finding not only sheds light on the relationship between hypertension and AD but also indicates novel methods for the prevention and treatment of AD. By identifying the critical role of stroke in the link between hypertension and AD, this study provides insights into potential interventions that could mitigate the impact of hypertension on AD. This could help develop personalized treatments and help improve the quality of life of patients with AD who suffer from hypertension.
Exploration-based model learning with self-attention for risk-sensitive robot control
Authors: Kim DongWook , Lee Sudong , Hong Tae Hwa , Park Yong-Lae 
Published: December 2023

AbstractModel-based reinforcement learning for robot control offers the advantages of overcoming concerns on data collection and iterative processes for policy improvement in model-free methods. However, both methods use exploration strategy relying on heuristics that involve inherent randomness, which may cause instability or malfunction of the target system and render the system susceptible to external perturbations. In this paper, we propose an online model update algorithm that can be directly operated in real-world robot systems. The algorithm leverages a self-attention mechanism embedded in neural networks for the kinematics and the dynamics models of the target system. The approximated model involves redundant self-attention paths to the time-independent kinematics and dynamics models, allowing us to detect abnormalities by calculating the trace values of the self-attention matrices. This approach reduces the randomness during the exploration process and enables the detection and rejection of detected perturbations while updating the model. We validate the proposed method in simulation and with real-world robot systems in three application scenarios: path tracking of a soft robotic manipulator, kinesthetic teaching and behavior cloning of an industrial robotic arm, and gait generation of a legged robot. All of these demonstrations are achieved without the aid of simulation or prior knowledge of the models, which supports the proposed method’s universality for various robotics applications.
Mixed-valence compounds based on heterometallic-oxo-clusters containing Sb(iii,v): crystal structures and proton conduction
Authors: Wen Wei-Yang , Ma Wen , Hu Bing , Xiao Hui-Ping , Pan Tian-Yu , Liu Jia-Ting , Lin Hao-Wei , Li Xin-Xiong , Huang Xiao-Ying 
Published: December 2023

Isostructural mixed-valence compounds H9.2[Co(H2O)6]{M0.5(H2O)3.5{M’(H2O)4[SbVO6[Co4.2(H2O)5SbIII6(μ3-O)2(tta)6]]}}2·nH2O (M = Co, M’ = Co, n = 9 (1); M = Cd0.39/Co0.61, M’ = Cd0.24/Co0.76, n = 7 (2)) were synthesized. The proton conductivity of 2 is 1.42 × 10−3 S·cm−1 at 85 °C and 98% RH.
Reduction of inappropriate principal features of the switched reluctance motor using sinusoidal rotor configuration
Authors: Torkaman Hossein , Sohrabzadeh Alireza 
Published: December 2023

AbstractThis paper presents a comprehensive analysis, electromagnetic evaluation, and prototyping of a novel motor structure called the sinusoidal rotor switched reluctance motor. In this innovative design, a significant departure from the conventional switched reluctance motor is observed, as modifications are made to the rotor with the goal of reduction torque ripple and radial force characteristics. Importantly, despite these advancements, the proposed motor retains the weight and volume characteristics of the traditional, type. The key attributes of these motors have been thoroughly assessed using the three‐dimensional finite element method, complemented by a sensitivity analysis aimed at identifying the most optimal configuration within the proposed design. The findings reveal that the suggested structure successfully achieves a notable reduction in torque ripple and radial force when compared to the traditional counterpart, albeit with an expected reduction in average torque. These features render the new topology particularly well‐suited for applications that prioritise noise and vibration reduction. Furthermore, the effectiveness of the proposed topology is corroborated through experimental tests, providing empirical evidence of its advantages and potential for practical applications.
Chirurgische Vorstellung eines innovativen
Gaumenimplantatsystems
Authors: Jung B. A. 
Published: December 2023

EinleitungDas Tomas System ist ein seit vielen Jahren etabliertes System für
Anwendungen im Bereich der skelettalen Verankerung. Seit einiger Zeit wurde die
Produktlinie durch die Einführung eines Gaumenimplantes (Tomas PI,
Dentaurum, Ispringen, Deutschland) erweitert.
Deutsche Übersetzung und Validierung des
patienten-orientierten Fragebogens „Thumb Disability
Examination“ (TDX) zur spezifischen Diagnostik und Verlaufskontrolle bei
Rhizarthrose
Authors: Mert Sinan , Emelianova Iana , Möllhoff Nicholas , Bader Moritz Christian , Giunta Riccardo , Maria Haas-Lützenberger Elisabeth 
Published: December 2023

Zusammenfassung
Hintergrund Patient-reported outcome measures (PROMs) nehmen einen immer
größeren Stellenwert in der gegenwärtigen
Patientenversorgung ein. Leider sind die gängigsten PROMs in der
Handchirurgie sehr zeitaufwändig und decken meist nicht die
tatsächlichen, diagnosespezifischen Beschwerden der Patienten ab. Zur
Diagnostik und Verlaufskontrolle bei Rhizarthrose entwickelten und validierten
Noback und Mitarb. den Fragebogen “Thumb Disability Examination”
(TDX). Dieser aus 20 Fragen bestehende Fragebogen erfasst gezielt die
Alltagseinschränkungen und Schmerzen sowie die patientenberichtete
Zufriedenheit der Daumenfunktion. Ziel dieser Studie ist die Validierung der
deutschen Übersetzung des TDX, der Thumb Disability Examination
– German (TDX-G), und dessen Vergleich mit den derzeitig als
Goldstandard verwendeten deutschsprachigen Versionen des MHQ und qDASH.
Material und Methoden Die Übersetzung und
Rückübersetzung erfolgte gemäß anerkannten
Richtlinien. Zur statistischen Validierung des TDX-G wurden 30 konsekutive
Patienten mit Rhizarthrose unter standardisierten Bedingungen befragt. Die
interne Konsistenz wurde mit Hilfe des Cronbach’s alpha berechnet. Die
Bestimmung der Test-Retest-Reliabilität erfolgte an 10 Patienten, die
den TDX-G in einem Intervall von 2 Wochen zweimal ausfüllten. Die
Validität des TDX-G wurde durch die Berechnung der
Korrelationskoeffizienten des TDX-G mit dem MHQ und qDASH, der subjektiven
Schmerzempfindung (NRS) und den Kraftgraden der Hand (Grob- und Pinchkraft)
bestimmt. Darüber hinaus wurde die Zeit zur Erhebung der einzelnen
Fragebögen verglichen.
Ergebnisse Der TDX-G weist eine hohe interne Konsistenz
(Cronbach’s alpha 0,932) und Test-Retest-Reliabilität
(Intraklassen-Korrelationskoeffizient 0,963 [0,850–0,991]) auf. Es
besteht eine signifikante Korrelation zwischen TDX-G und MHQ
(− 0,782; p<0,001) sowie qDASH (0,833; p<0,001).
Alle Fragebögen korrelieren signifikant mit den Schmerzen bei Belastung
und der Pinchkraft, wobei der TDX-G jeweils die höchste Korrelation
aufweist. Die Zeit zur Erfassung des TDX-G (110±28 s) ist
signifikant geringer als zur Erfassung des MHQ (413±98 s).
Schlussfolgerung Der TDX-G ist ein reliables Instrument zur Diagnostik und
Verlaufskontrolle der Rhizarthrose, das sowohl in der Patientenversorgung als
auch der klinischen Forschung gezielt eingesetzt werden kann und die Beschwerden
präzise ablichtet.
Transient Perivascular Inflammation of the Carotid Artery as a Poorly Recognized Cause of Neck Pain
Authors: Greutert Sophie , Schlomer Tatiana , Righini Marc 
Published: December 2023

AbstractTransient perivascular inflammation of the carotid artery (TIPIC) syndrome, historically named idiopathic carotidynia or Fay syndrome, is a rare condition characterized by inflammation and pain in the carotid artery. The diagnosis requires a specific clinical–radiological presentation. We describe a 37-year-old female who presented with headaches and left neck pain and was diagnosed with TIPIC syndrome with temporary perivascular infiltration.
A Review of the Effectiveness of Homoeoprophylaxis: SARS-CoV-2 Compared to Pre-COVID-19 Infectious Diseases
Authors: Golden Isaac , Bracho Gustavo 
Published: December 2023

AbstractFrom Hahnemann's use in 1799 of Belladonna 30 to prevent scarlet fever, to the prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2023, appropriate potencies of similarly 'similar' remedies have been used to prevent targeted infectious diseases. This is known to many as homeoprophylaxis (HP) or 'similar prevention.' Data from recent surveys suggest that the effectiveness of HP remedies against SARS-CoV-2 is lower compared to other infectious diseases. This review examines relevant evidence and suggests possible explanations for the emerging difference and ways to improve HP effectiveness. Evidence of HP's effectiveness against a range of infectious diseases from 1974 to 2014 is compared with evidence of HP's effectiveness against SARS-CoV-2 collected from 2020 to 2022. A summary of the evidence, describing the use of over 247,000,000 doses of HP medicines against various infectious diseases, suggests an average effectiveness of around 88%. Another summary of the evidence, describing the use of HP by several authors in 2020, 2021, and 2022 against SARS-CoV-2, shows a range of effectiveness around 70%. The reasons for apparent differences in HP effectiveness between 'traditional' infectious diseases and SARS-CoV-2 are discussed. It is suggested that these differences could have been expected, particularly due to the quality of most nosodes against SARS-CoV-2. The value of HP in comparison to coronavirus disease 2019 vaccines is also discussed, and conclusions are drawn. Appropriate HP against SARS-CoV-2 offers an option that appears to be at least as effective as vaccination, without any risk of toxic damage, but there is room for improvement.
Surface to Perforator Index: Assessing the Importance of the Number of Perforators in Successful Harvesting of the Anterolateral Thigh Flap
Authors: Saad Noah , McGill Michelle , Karamitros Georgios , Cromack Douglas , Wang Howard , Fisher Samuel , Karamanos Efstathios 
Published: December 2023

Abstract
Background The use of perforator flaps has become more popular with improvement of surgical technique, technology, as well as understanding of microvascular anatomy. The selection of well-perfused angiosomes is critical to the successful outcome of patients undergoing free tissue transfer. The number of perforators that are needed is dependent upon the surface area of the flap being harvested; however, there have been no studies to assess the optimal surface area supplied by each perforator. We hypothesized that the smaller the surface area supplied by each perforator correlated with fewer flap-related complications in the harvesting of the anterolateral thigh (ALT) flap.
Methods All ALT flaps harvested from 2015 to 2021 at our institution were retrospectively reviewed. The surface area of the flap harvested was calculated as A = πab, where a is the long radius and b is the short radius of the ellipse. The surface-perforator index (SPI) was calculated for each flap by dividing the surface area of the ALT flap by the number of perforators supplying the flap. Our primary outcomes were flap-related complications that included: partial flap loss, dehiscence, and venous congestion.
Results A total of 106 patients were identified. Twenty-four patients (22.6%) developed perforator-related complications. An increasing SPI and SPI to body surface area were strongly associated with development of complications (adjusted odds ratio [95% confidence interval], adjusted p: 1.02 [1.01, 1.03], < 0.001and 1.23 [1.12, 1.42], p < 0.001). An SPI of greater than 150 cm2/perforator was associated with a higher probability of complications (p < 0.001).
Conclusion Flap-related complications are significantly related to the number of perforators supplying the flap. The smaller the surface area supplied by a single perforator correlates with significantly fewer flap-related complications. SPI is a new index that may be used as a predictive tool to aid in identifying flaps that may be more prone to complications in free tissue transfer.
A Call for Transformative Intersectional LPAA Intervention for Equity and Social Justice in Ethnosocially Diverse Post-Stroke Aphasia Services
Authors: Centeno José G. 
Published: December 2023

AbstractThe disproportionate health disparities in ethnoracial groups highlighted by the COVID-19 pandemic catalyzed a sociopolitical momentum for transformative approaches in health care. As the U.S. population progressively becomes more ethnoracially diverse and older, growing vulnerable ethnogeriatric groups of older individuals with contrasting ethnic/racial and social histories are estimated to experience age-related cardiovascular complications with resulting chronic disabilities, such as post-stroke aphasia. Grounded in principles of equity and social justice, transformative health care approaches use input from marginalized communities to inform service strategies to minimize health disparities. This article discusses the population scenario, principles, and possible strategies to support the call for stakeholder-informed intervention toward the social reintegration of ethnosocially mixed geriatric populations with aphasia in the United States. Based on the principles from the Life Participation Approach to Aphasia (LPAA) and intersectional narratives, we discuss how client and caregiver stories can inform culturally authentic individualized aphasia intervention for social readaptation. We conclude with future directions in aphasia education, research, and practice to promote stakeholder-informed strategies for culturally aligned social reintegration of older ethnosocially diverse aphasia populations in post-stroke care.
The impact of social exclusion and identity on migrant workers’ willingness to return to their hometown: micro-empirical evidence from rural China
Authors: Xu Haiping , Wu Wenjia , Zhang Chuqiao , Xie Yibo , Lv Jinge , Ahmad Shahzad , Cui Zengrui 
Published: December 2023

AbstractThe return of rural migrant workers to employment is an endogenous force that drives the development of the rural economy and plays a vital role in rural revitalization. Using data from the China Migrants Dynamic Survey (CMDS) conducted in 2017, this study comprehensively examines the influence of social exclusion and the role of identity on migrant workers’ willingness to return home (MWRH). The findings indicate a significant impact of social exclusion on MWRH, and this relationship remains robust even after employing instrumental variables to address endogeneity concerns. Identity emerges as a crucial mediating factor through which social exclusion affects MWRH, demonstrating a partial mediating effect. Notably, the impact of social exclusion on MWRH is particularly prevalent among rural residents in the western and northeastern regions, the older generation, those with lower incomes, and those with limited intra-provincial mobility. Promoting a positive image of migrant workers and encouraging their pursuit of an improved quality of life can help alleviate social exclusion, strengthen their sense of identity, and foster deeper roots in cities. Furthermore, providing supportive platforms for returning migrant workers can enhance their active willingness to return home.
Towards an antifragility framework in past human–environment dynamics
Authors: Jaffe Yitzchak , Caramanica Ari , Price Max D. 
Published: December 2023

AbstractScholarship on human–environment interactions tends to fall under two headings: collapse or resilience. While both offer valid explanatory frameworks for human–environment dynamics, both view stress as a net negative that, if unchecked, disrupts systems in equilibrium. Societies either succumb to stress (and collapse) or overcome stress and persist (demonstrate resilience). We re-evaluate the role of stress and advocate for a non-equilibrium approach to the study of past human–environment interactions. We draw inspiration from Nasim Taleb’s concept of ‘antifragility’, which posits a positive role of stress for increasingly complex systems. We apply antifragility as an explanatory framework to pre-Hispanic coastal Peru, where indigenous farmers adapted to the stresses of highly variable El Niño events through a variety of water management systems. Finally, we note that an antifragility approach highlights the beneficial role of stressors, and that avoiding stress altogether makes a system more fragile.
Regulation of static and dynamic magnetic properties of amorphous FeCoZr composition gradient films by Zr doping
Authors: Song Chengji , Han Zeyu , Zhou Jie , Wang Xuan , Zhang Luran , Ma Zhi , Ma Li , Zheng Fu 
Published: December 2023

A series of amorphous FeCoZr composition gradient monolayer films with varying Zr contents was prepared on the Si(100) substrate using RF magnetron sputtering. The effects of the Zr sputtering power PZr on the static and dynamic magnetic properties of FeCoZr films were systematically investigated. The results demonstrate that the introduction of the Zr element as a composition gradient into FeCo films not only improves the soft magnetic properties of the films but also enhances their in-plane uniaxial magnetic anisotropy. In particular, the doping of Zr elements leads to the destruction of FeCo lattice, inducing a transformation of the films from polycrystalline to amorphous state, resulting in a significant decrease in coercivity (Hc reduced by 82%) and surface roughness (Ra reduced by 78%). In addition, as PZr increases from 30 to 70 W, the anisotropy fields Hk of the films increase from 128 to 340 Oe, and the resonance frequency fr increases from 4.24 to 5.23 GHz. By fitting the permeability spectrum using the LLG equation, it is found that FeCoZr composition gradient films exhibit a lower damping coefficient α of around 0.011–0.014, indicating the reduction of energy loss during magnetization dynamics. These findings highlight the potential applications of FeCoZr composition gradient films in the field of high-frequency microwaves.