bluuebunny/crossref_metadata_2025_split huggingface dataset:
GAMBARAN KADAR HEMOGLOBIN PADA MAHASISWA SEBELUM DAN SESUDAH MENGKONSUMSI MIE INSTAN
Authors: Wisma Wati Dian 
Published: November 2023

Riskesdas tahun 2018, menyebut 7,8% penduduk indonesia mengkonsumsi mie instan/makanan lainnya setiap harinya. Pada provinsi jawa timur menyebut 4,6% penduduk indonesia mengkonsumsi mie instan/makanan lainnya setiap harinya. Mie instan telah menjadi makanan pokok dunia yang memiliki banyak varian rasa, harga terjangkau dan memiliki waktu simpan jangka panjang. Saat ini mie instan menjadi makanan favorit banyak orang salah satunya adalah mahasiswa. Konsumsi mie instan berlebihan tanpa menambahkan sumber protein akan mengganggu proses pembentukkan hemoglobin yang membutuhkan makanan kaya zat besi. Penelitian ini bertujuan untuk mengetahui gambaran kadar hemoglobin sebelum dan sesudah mengkonsumsi mie instan pada mahasiswa jurusan TLM. Penelitian ini menggunakan jenis penelitian deskriptif analitik. Penelitian ini dilakukan di Laboratorium Hematologi Jurusan TLM Politeknik Kesehatan Kemenkes Surabaya pada Oktober 2021 sampai dengan April 2022. Sampel dalam penelitian adalah wanita atau pria berusia 18 sampai 22 tahun, wanita tidak sedang menstruasi dan pria bukan perokok yang telah memenuhi kriteria sebanyak 30 orang yang akan diperiksa kadar hemoglobin sebelum dan sesudah mengkonsumsi mie instan. Pemeriksaan kadar hemoglobin menggunakan alat POCT. Hasil penelitian menunjukkan bahwa rata-rata nilai kadar hemoglobin sebelum mengkonsumsi mie instan dalam kategori normal memiliki rerata sebesar 14,0 g/dl dan standar deviasi 1,767, sedangkan kadar hemoglobin sesudah mengkonsumsi mie instan dalam kategori normal memiliki rerata sebesar 13,9 g/dl dan standar deviasi 1,537, sehingga dapat disimpulkan bahwa kadar hemoglobin pada mahasiswa sebelum dan sesudah mengkonsusmsi mie instan mengalami penurunan
Penguatan Kapabilitas BUMDes “Sindangkarya” Desa Sindangheula Dalam Pengembangan Bisnis
Authors: Saefullah Encep , Mukhlis Ahmad , Khaerudin Dedy 
Published: November 2023

Mitra dalam Pemberdayaan Kemitraan Masyarakat (PKM) ini adalah Pemerintah Desa Sindangheula, pengelola BUMDes “Sindangkarya” dan pelaku UMKM Sapu sebagai unit usaha BUMDes “Sindangkarya”. Tujuan PKM ini adalah (1), Peningkatan produktivitas melalui perbaikan proses produksi; (2) Pendampingan pemrosesan permohonan perolehan merk dagang; (3) Peningkatan volume penjualan melalui pengelolaan website; (4) Pelatihan dan pendampingan pemilihan dan pemilahan bahan baku kualitas; dan (5) Meriset metode pemotongan lidi dan ijuk agar diperoleh metode dan teknologi pemotongan yang optimal untuk menunjang proses produksi. Untuk mencapai tujuan tersebut tim pengabdi menyusun rencana kegiatan yang meliputi 4 (empat) tahap, yaitu tahap 1 analisis situasi dan kondisi mitra, tahap 2 persiapan dan transfer Ipteks, tahap 3 pelatihan dan pendampingan dan tahap 4 evaluasi dan keberlanjutan program. Dengan menggunakan metode kronologis, pelaksanaan kegiatan ini menghasilkan peningkatan produktivitas dari penggunaan mesin pemotong lidi pada proses produksi, peningkatan volume penjualan dari penggunaan website sebagai media pemasaran online
The partners in Community Partnership Empowerment (PKM) are the Sindangheula Village Government, the management of the BUMDes "Sindangkarya" and the Sapu MSME actors as the BUMDes "Sindangkarya" business unit. The objectives of this PKM are (1), Increasing productivity through improving the production process; (2) Assistance in processing applications for obtaining trademarks; (3) Increasing sales volume through website management; (4) Training and assistance in selecting and sorting quality raw materials; and (5) Researching methods for cutting sticks and fibers in order to obtain optimal cutting methods and technology to support the production process. To achieve this goal, the service team prepared an activity plan which included 4 (four) stages, namely stage 1 analysis of the partner's situation and condition, stage 2 of preparation and transfer of science and technology, stage 3 of training and mentoring and stage 4 of program evaluation and sustainability. By using the chronological method, the implementation of this activity resulted in an increase in productivity from the use of stick-cutting machines in the production process, an increase in sales volume from the use of the website as an online marketing medium
Pencegahan Stunting Pada Anak di Desa Mekarsari, Bogor: Sebuah Tinjauan Literatur
Authors: Sovitriana Rilla , Gusliana Mais Rimi , Sintawati Sri 
Published: November 2023

Di Kabupaten Bogor kasus stunting terjadi penurunan di tahun 2021 menjadi 9,89%dengan target 2023 Kabupaten Bogor Bebas Stunting. Namun di Desa Mekarsari masih ditemukananak stunting sebanyak 27 orang. Desa Mekarsari memiliki jumlah penduduk 6.392jiwadengan tingkat pendidikan maksimal SLTA. Tahun 2021 terdapat 1.713 jiwa yang belum mendapatkan pekerjaan sehingga menyebabkan rendahnya kesadaran terhadap kesehatan dan ekonomi keluarga. Hal ini mengakibatkan kurang terpenuhinya gizi keluarga dan stunting padaanak. Metode yang digunakan adalah dengan menggunakan studi literatur dari berbagai jurnalinternasional dan nasional, yang berusaha merangkum pengetahuan terkini tentang suatu topik.Studi literatur mengambil literatur yang diterbitkan sebelumnya dan melaporkan fakta atauanalisis baru dan ulasan literatur yang memberikan ringkasan publikasi terbaik dan palingrelevan, dan kemudian membandingkan hasil yang disajikan dalam artikel.
In Bogor Regency, stunting cases have decreased in 2021 to 9.89% with a target of 2023, Bogor Regency is Stunting Free. However, in Mekarsari Village there were still 27 stunted children. Mekarsari village has a population of 6,392 people with a maximum education level of high school. In 2021 there are 1,713 people who have not found work, causing low awareness of health and the family economy. This results in inadequate family nutrition and stunting in children. The method used is to use literature studies from various international and national journals, which attempt to summarize the latest knowledge on a topic. A literature study takes previously published literature and reports on facts or new analyzes and reviews of the literature that provide a summary of the best and most relevant publications, and then compares the results presented in the articles
Merger Interactions Enhance Star Formation Rates in Galaxy Group Housing QSO PKS0405−123 and Gaseous Nebulae
Authors: Wolter Ian E. , Berg Michelle A. , Chisholm John 
Published: November 2023

Abstract
The star formation rate (SFR) of galaxies can change due to interactions between galaxies, stellar feedback ejection of gas into the circumgalactic medium, and energy injection from accretion onto black holes. However, it is not clear which of these processes dominantly alters the formation of stars within galaxies. Johnson et al. reported the discovery of large gaseous nebulae in the intragroup medium of a galaxy group housing QSO PKS0405−123 and hypothesized they were created by galaxy interactions. We identify a sample of 30 group member galaxies at z ∼ 0.57 from the Very Large Telescope/Multi Unit Spectroscopic Explorer observations of the field and calculate their [O ii]λλ3727,3729 SFRs in order to investigate whether the QSO and nebulae have affected the SFRs of the surrounding galaxies. We find that star formation is more prevalent in galaxies within the nebulae, signifying galaxy interactions are fueling higher SFRs.
Use of Coordinator Role Improves Access to Rheumatologic Advanced Therapy
Authors: Farrer Chandra , Thib Sydney , Eder Lihi , Jerome Dana , Gakhal Natasha 
Published: November 2023

ObjectiveDelays in initiation of advanced therapies, which include biologics and targeted synthetic disease-modifying antirheumatic drugs, contribute to poor patient outcomes. The objective of this quality improvement project was to identify factors that lead to a delay in the initiation of advanced therapy and to perform plan-do-study-act cycles to decrease the time to start advanced therapy.MethodsA retrospective chart review identified factors involved in delay to start advanced therapy. The primary outcome of the study was the number of days to advanced therapy start as measured by the date of rheumatologist recommendation to the date advanced therapy was initiated by the patient. An Advanced Therapy Coordinator role was created to standardize the workflow, optimize communication, and ensure a safety checklist was instituted.ResultsA total of 125 patients were reviewed for the study with 18 excluded. Preintervention median wait time was 82.0 (IQR 46.0-80.5) days. Median wait time during the intervention improved to 49.5 (IQR 34.0-69.5) days (April 2021 to January 2022), with nonrandom variation post intervention. Nonrandom variation was also noted in the latter baseline data (March 2020 to March 2021).ConclusionThis study demonstrates improved wait time to advanced therapy initiation through the role of an Advanced Therapy Coordinator to facilitate communication pathways.
“Il était [mille] fois, un juif désespérément heureux” : ou comment expliquer la Shoah aux enfants (André Schwarz‑Bart)
Authors: Gyssels Kathleen 
Published: November 2023

Kathleen Gyssels onderzoekt de paradox dat in de roman die als ‘volwassen’ wordt aangestipt, het kind toch centraal staat: enerzijds door de jonge leeftijd van het hoofdpersonage dat wordt geconfronteerd met de opkomst van het nazisme; daarnaast door het ‘geloof’ in verhalen en sprookjes, wanneer hij als gulzige ‘zondagse’ Jood sprookjes verslindt (‘Er was eens’); en ten slotte door de impact van beelden op een ogenblik dat de taal nog in ‘opbouw’ is. Gedurende zijn hele schrijverscarrière ondernam André Schwarz-Bart talrijke pogingen om kinderen over de Shoah te vertellen.
Éric David. “Nuremberg. Droit de la force et force du droit”
Authors: Coutin Willy 
Published: November 2023

LIVRE : En décembre 2017, un quatrième crime relevant de la compétence de la Cour pénale internationale (CPI) a été adopté par l’Assemblée des États parties au traité de Rome de 1998 qui l’avait instituée. Il s’agit de l’emploi par un État de la force armée contre la souveraineté, l’intégrité ou l’indépendance d’un autre État (ou « guerre d’agression »). Entré en vigueur en 2002, le traité de Rome confie à la CPI la charge de juger des personnes, responsables politiques ou militaires, accusées de crimes de guerre, crimes contre la paix et crimes contre l’humanité. On retrouve là trois des quatre chefs d’accusation que définirent les vainqueurs de l’Allemagne nazie dans les accords de Londres du 8 juillet 1945 qui établissaient le champ d’action du Tribunal militaire international qui s’apprêtait à siéger à Nuremberg. Ce procès fit prendre un tournant historique au traitement réservé aux crimes commis dans le cadre de conflits et à la définition d’une communauté internationale décidée à ne plus accepter l’impunité des auteurs d’atrocités bafouant le sens commun et les valeurs universelles. Aujourd’hui, 123 pays sont États parties au traité de Rome.
Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1
Authors: Nagai-Singer Margaret A , Woolls Mackenzie K , Leedy Katerina , Hendricks-Wenger Alissa , Brock Rebecca M , Coutermarsh-Ott Sheryl , Paul Tamalika , Morrison Holly A , Imran Khan M , Tupik Juselyn D , Fletcher Endia J , Brown David A , Allen Irving C 
Published: November 2023

Abstract
Prior studies have defined multiple, but inconsistent, roles for the enigmatic pattern recognition receptor NLRX1 in regulating several cancer-associated biological functions. In this study, we explore the role of NLRX1 in the highly metastatic murine 4T1 mammary tumor model. We describe a functional dichotomy of NLRX1 between two different cellular contexts: expression in healthy host cells versus expression in the 4T1 tumor cells. Using Nlrx1−/− mice engrafted with 4T1 tumors, we demonstrate that NLRX1 functions as a tumor suppressor when expressed in the host cells. Specifically, NLRX1 in healthy host cells attenuates tumor growth and lung metastasis through suppressing characteristics of epithelial–mesenchymal transition and the lung metastatic niche. Conversely, we demonstrate that NLRX1 functions as a tumor promoter when expressed in 4T1 tumor cells using gain- and loss-of-function studies both in vitro and in vivo. Mechanistically, NLRX1 in the tumor cells augments 4T1 aggressiveness and metastasis through regulating epithelial–mesenchymal transition hallmarks, cell death, proliferation, migration, reactive oxygen species levels, and mitochondrial respiration. Collectively, we provide critical insight into NLRX1 function and establish a dichotomous role of NLRX1 in the 4T1 murine mammary carcinoma model that is dictated by cellular context.
Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis
Authors: Akbar Irshad , Tang Ruihan , Baillargeon Joanie , Roy Andrée-Pascale , Doss Prenitha Mercy Ignatius Arokia , Zhu Chen , Kuchroo Vijay K , Rangachari Manu 
Published: November 2023

Abstract
Th1 cells are critical in experimental autoimmune encephalomyelitis (EAE). Serine protease inhibitor clade E1 (Serpine1) has been posited as an inhibitor of IFN-γ from T cells, although its role in autoimmunity remains unclear. In this study, we show that Serpine1 knockout (KO) mice develop EAE of enhanced severity relative to wild-type (WT) controls. Serpine1 overexpression represses Th1 cell cytokine production and pathogenicity, whereas Serpine1-KO:2D2 Th1 cells transfer EAE of increased severity in comparison with WT 2D2 Th1 cells. Notably, polarized Serpine1-KO Th1 cells display delayed expression of the Th1-specific inhibitory receptor, Tim-3 (T cell Ig and mucin–domain containing-3). Serpine1-KO:Tim-3-Tg Th1 cells, which transgenically overexpress Tim-3, showed increased expression of IFN-γ and reduced expression of the checkpoint molecules Lag-3 and PD-1 relative to WT Tim-3-Tg counterparts. Furthermore, Serpine1 deficiency restored the EAE phenotype of Tim-3-Tg mice that normally develop mild disease. Taken together, we identify Serpine1 as a negative regulator of Th1 cells.
Leveraging a Diverse Collaboration in Tertiary Education to Develop Capability for Workplace Innovation
Authors: Carey Thomas , Baregheh Anahita , Nobis Felix , Stevenson Mathias 
Published: November 2023

Recent developments in tertiary education are demonstrating teaching and learning methods to develop students’ capability for employee-led Workplace Innovation. In this article, we describe an international collaboration to develop shared learning resources and activities in workplace innovation for adaptation in diverse tertiary education contexts. We are intentionally seeking out additional collaborating institutions that differ in mission, size, location and student demographics, to leverage our team’s diversity and encourage innovation.
When shared learning resources and activities are to be used in a diverse contexts, some core principles underlying instructional success must also be shared in order to ensure adaptations do not remove key properties. We outline four instructional principles underlying the learning design and illustrate how these principles are applied in our current learning resources.
We then describe some of the ways that these shared resources have been adapted for different tertiary education environments. We also discuss some of the benefits emerging from the collaboration, including how the inclusion of new resources targeting specific work domains and the transfer of new teaching and learning ideas across contexts.
We conclude by describing some of the ways we are also collaborating with workplace partners, to ensure that our graduates have the capabilities needed to contribute to workplace innovation practice and to help advance the workplace innovation capability of their own employees.
STRATEGI PENGEMBANGAN USAHA KECIL MENENGAH (UMKM) KEDAI KOPI ONGAKU KOTA BENGKAYANG BERDASARKAN ANALISIS SWOT
Authors: Manggu Blasius , Beni Sabinus 
Published: November 2023

Penelitian ini dilatarbelakangi oleh banyaknya Usaha Mikro Kecil Menengah (UMKM) yang berwirausaha dalam bidang yang sejenis yaitu kedai kopi di kota Bengkayang yang nota bene saling berkompetitif satu sama lain untuk meraih konsumen. Oleh karena itu, perlu merumuskan suatu strategi yang tepat agar tetap bertahan merebut pangsa pasar. Deskriptif kualitatif termasuk jenis dari pada penelitian ini. Populasi penelitian ini adalah konsumen Kedai Kopi Ongaku dengan jumlah responden berjumlah 30 orang. Pengumpulan data dilakukan melalui wawancara dengan responden dan menyebarkan kuesioner. Teknik analisis data menggunakan SWOT (Strength, Weaknesses, Opportunities, dan Threats). Untuk mengidentifikasi rumusan strategi yang secara sistematis berbagai faktor pada perusahaan maka analisis SWOT sangatlah disarankan. Berdasarkan pada logika hasil analisis yang dapat memaksimalkan kekuatan (strengths) dan peluang (opportunities), namun secara bersamaan dapat meminimalkan kelemahan (weaknesses) dan ancaman (threats), juga menyertakan penggunaan tabel IFAS dan EFAS. Tabel IFAS, tabel untuk mengetahui lingkungan internal dalam perusahaan, kekuatan dan dan kelemahannya, IFAS, tabel yang memuat faktor eksternal yang mempengaruhi lingkungan perusahaan. Berdasarkan analisis dari penelitian ini menunjukkan bahwa Usaha Mikro Kecil Menengah (UMKM) Kedai Kopi Ongaku berada pada kuadran IV pemanfaatan strategi diversifikasi, yaitu memanfaatkan kekuatan (strength) yang dimiliki dalam menghadapi ancaman (threats) guna bersaing dengan para kompetitor
TEKNIK BUDIDAYA JAMUR SEBAGAI DIVERSIFIKASI PRODUK AGROFORESTRY DI KELOMPOK TANI HUTAN (KTH) MEKAR BAKTI, KARANG JOANG, BALIKPAPAN
Authors: Herawati Elisa , Murniyati Agustina , Rositah Erna , Kardika Adelia Juli , Ningsih Rusdiana , Lubis Putri Patricia 
Published: November 2023

Jamur adalah salah satu alternatif bahan pangan kaya gizi dan antioksidan alami. Jamur tiram (Pleurotus ostreatus) merupakan salah satu jamur yang paling banyak dibudidayakan. Jamur tiram banyak dipelajari karena memiliki rasa dan kandungan nutrisi dan khasiat sebagai obat, sebagai sumber nutrisi, karbohidrat, vitamin ,kalsium dan zat besi. Mitra dalam kegiatan Pengabdian Kepada Masyarakat ini adalah Kelompok Tani Hutan (KTH) Mekar Bakti. Adapun permasalahan yang dihadapi oleh KTH ini yaitu pandemi covid-19 masih ada; hasil komoditi yang diusahakan petani bersifat musiman; diperlukan jenis komoditi yang yang dapat dipanen setiap hari; limbah pertanian dan lahan yang tersedia belum benar-benar dimanfaatkan secara optimal; dan masyarakat petani KTH Mekar Bakti belum memiliki pengalaman, kapasitas dan keterampilan sumber daya manusia khususnya dalam hal budidaya jamur. Metode pelaksanaan kegiatan pengabdian ini berupa pemaparan domestikasi jamur konsumsi dan praktik pelatihan domestikasi. Hasil dari kegiatan pengabdian ini telah memberikan manfaat pengetahuan berupa pengenalan jamur yang dapat dikonsumsi dan dibudidayakan serta pengembangan kemampuan dalam berwirausaha para angota KTH Mekar Bakti. Kegiatan pembudidayaan ini mendorong para angota untuk mempraktekkan secara langsung, yang nantinya dapat mereka gunakan untuk memenuhi kebutuhan mereka sehari-hari ataupun dapat dijual. Tentunya dengan kondisi seperti ini, produktivitas masyarakat dapat ditingkatkan. Pembudidayaan ini juga melalui kegiatan konsumsi jamur dapat menambah gizi bagi orang-orang yang mengkonsumsinya.
Proton pump inhibitors- Adversaries in our fight against antibiotic resistance?
Authors: Umar Sumayya , Ejaz Zoya , Masood Faizan 
Published: November 2023

Madam,
The proton-pump inhibitors (PPIs) belong to a class of medications that reduce stomach acid production by irreversibly inhibiting the stomach's H+/K+ ATPase pump. These medications are used in the treatment of many conditions, such aspeptic ulcer, gastroesophageal reflux, as part of H. Pylori eradication, gastrinomas, Barrett’s oesophagus and many other conditions. They are considered to be the most potent inhibitors of acid secretion, and have largely supplanted the H2 receptor antagonists and antacids. They are also among the most widely sold medications worldwide. The class of proton pump inhibitors is listed on WHO’s list of essential medicines.1Proton pump inhibitors are generally well tolerated. However, headache, nausea, diarrhoea, abdominal pain, fatigue, and dizziness are identified as some of the common side effects. Due to their efficacies and low risk profile, PPIs are often prescribed for extend than required period.
Several recent studies have shown that long-term PPI use is associated with various adverse outcomes. A 2023 study published in JAMA Network Open demonstrated that long-term use of PPIs may lead to an increased risk of acquiring extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing enterobacterales.2Another study3 published in 2022 showed that PPI use was the only modifiable factor associated with the carriage of ESBL producers in residents of long-term care facilities. These studies add to the expanding list of adverse outcomes associated with PPIs. Other adverse events of long-term PPI use, include the risk of fractures, pneumonia, Clostridium difficile diarrhoea, hypomagnesaemia, vitamin B12deficiency, chronic kidney disease, and dementia.4
Proton pump inhibitors are still used widely in Pakistan. These new findings are concerning as ESBL-producing Enterobacteriaceae are highly prevalent in Pakistan. A meta-analysis showed that the overall pooled proportion of ESBLs in Pakistan is 40%5 whereas the German population showed an estimated ESBL proportion in the range of 10 to 15% and a US census reported 4 to 12% resistance due to ESBLs.5 This calls for a strict prescription control of PPIs by Pakistani physicians, and the duration of PPI use should not extend for longer than needed. In addition, the practice of PPI’s over the counter sale by the pharmacists in Pakistan should be stopped. Additional precautions should be taken in hospitalized patients who are using PPIs to prevent them from getting multi-drug resistant infections.