bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of cardiac–coronary interaction and insights from mathematical modeling
Authors: Fan Lei , Wang Haifeng , Kassab Ghassan S. , Lee Lik Chuan 
Published: February 2024

AbstractCardiac–coronary interaction is fundamental to the function of the heart. As one of the highest metabolic organs in the body, the cardiac oxygen demand is met by blood perfusion through the coronary vasculature. The coronary vasculature is largely embedded within the myocardial tissue which is continually contracting and hence squeezing the blood vessels. The myocardium–coronary vessel interaction is two‐ways and complex. Here, we review the different types of cardiac–coronary interactions with a focus on insights gained from mathematical models. Specifically, we will consider the following: (1) myocardial–vessel mechanical interaction; (2) metabolic–flow interaction and regulation; (3) perfusion–contraction matching, and (4) chronic interactions between the myocardium and coronary vasculature. We also provide a discussion of the relevant experimental and clinical studies of different types of cardiac–coronary interactions. Finally, we highlight knowledge gaps, key challenges, and limitations of existing mathematical models along with future research directions to understand the unique myocardium–coronary coupling in the heart.This article is categorized under:
Cardiovascular Diseases > Computational Models
Cardiovascular Diseases > Biomedical Engineering
Cardiovascular Diseases > Molecular and Cellular Physiology
Well‐defined Bis(imino)pyridine‐Manganese(II) Complexes for Oxidation of Benzylic C−H Bonds
Authors: Dey Jyotirmoy , Raj Lakshkar Ritu , Sahil Deepika , Prakash Joshi Om , Yadav Seema , Singh Ajeet , Ray Sriparna , Dash Chandrakanta 
Published: February 2024

AbstractTwo new manganese(II) complexes bearing bis(imino)pyridine pincer ligands have been synthesized. These manganese(II) complexes were characterized by UV, IR, elemental analysis studies, and X‐ray crystallography. The X‐ray crystal data of manganese complexes revealed distorted trigonalbipyramidal geometries around the manganese ion and neutral tridentate N^N^N coordination mode for bis(imino)pyridine (BIP) ligand. The catalytic properties of manganese(II) complexes were explored for the catalytic oxidation of the benzylic C−H bonds using TBHP as an oxidant. The corresponding carbonyl compounds have been produced in moderate to excellent yields.
A comparative machinability analysis of polyimine vitrimer, epoxy and polycarbonate polymers through orthogonal machining experiments
Authors: Poór Dániel István , Tobey Marina , Taynton Philip , Pomázi Ákos , Toldy Andrea , Geier Norbert 
Published: February 2024

AbstractEnd-of-life management of fibre-reinforced thermoset composites is challenging due to the difficult-to-recycle reinforcements and the irreversibly polymerised thermoset matrix; therefore, researchers proposed the vitrimers as a sustainable alternative to thermosetting polymers. Although the early results of the material scientists are promising, the machinability of vitrimers has yet to be explored. Therefore, this paper aims to present a comparative machinability study of polyimine vitrimer, pentaerythritol-based epoxy (PER) and polycarbonate polymers through orthogonal machining experiments. Reflecting on the temperature-dependent properties of vitrimers, the starting temperature of the cutting tool was varied between room temperature and an elevated temperature above 155 °C. The cutting tool was heated by a 2000-W hot air gun until the surface temperature of the cutting tool, monitored by a VariocamHD thermographic IR camera (with Jenoptik IR 1.0/60 LW lens) and checked by a Fluke 51 II thermometer with a type K thermocouple, was permanently above 155 °C for 5 min. The cutting force was measured by a Kistler 9257B dynamometer, and the machined surface was characterised by a Mitutoyo Surftest SJ-400 surface roughness tester and Keyence VHX-5000 (with VH-Z20UT VH lens) microscope. The analysis of variances (ANOVA) results show that the sustainable vitrimer polymer is an appropriate substitute for thermosetting epoxy polymers, especially at low cutting temperatures.
In-situ positron annihilation spectroscopy during tensile tests on Al alloys
Authors: Hugenschmidt Christoph , Thalmayr Matthias , Gigl Thomas 
Published: February 2024

AbstractWe present a materials analysis method to enable in-situ Doppler broadening spectroscopy (DBS) of the 511 keV annihilation line in matter during tensile tests. This technique allows the correlation between the formation of lattice defects on an atomic scale and the macroscopic physical materials properties stress and strain. By implanting a monoenergetic positron beam into samples of AlMg3 (3.3535) and AlMgSi (3.3206) the onset of plastic deformation was clearly observed in the recorded annihilation spectra during the measurement of the corresponding stress–strain curves. The changes of the DBS spectra are attributed to positron annihilation in (open-volume) defects—predominantly vacancies elastically bound to dislocation lines—formed during plastic deformation. The elastic strain (Hook’s region), however, does not lead to changes in DBS spectra.
Do we need MRI in all biopsy naïve patients? A multicenter cohort analysis
Authors: Krausewitz Philipp , Borkowetz Angelika , Ortner Gernot , Kornienko Kira , Wenzel Mike , Westhoff Niklas ,   GESRU Academics Prostate Cancer Group
Published: February 2024

Abstract
Purpose
The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicion of clinically significant prostate cancer (csPCA). However, the unbalanced accessibility of MRI, challenges related to reimbursement and the scarcity of specialized medical practitioners continue to impede a widespread implementation.
Therefore, our objective was to determine a subset of men that could undergo SB without an increased risk of underdiagnosis at reduced expenses.

Methods
A multicenter analysis of 2714 men with confirmed PCA and suspicious MRI who underwent CB were enrolled. Cancer detection rates were compared between the different biopsy routes SB, TB and CB using McNemar paired test. Additionally, Gleason grade up- and down-grading was determined.

Results
CB detected more csPCA than TB and SB (p < 0.001), irrespective of MRI findings or biopsy route (transperineal vs. transrectal). Thereby, single biopsy approaches misgraded > 50% of csPCA. TB showed higher diagnostic efficiency, defined as csPCA detection per biopsy core than CB and SB (p < 0.001). For patients with abnormal DRE and PSA levels > 12.5 ng/ml, PSAD > 0.35 ng/ml/cm3, or > 75 years, SB and CB showed similar csPCA detection rates.

Conclusion
Conducting CB provides the highest level of diagnostic certainty and minimizes the risk of underdiagnosis in almost all biopsy-naive men. However, in patients with suspicious DRE and high PSA levels, PSAD, or advanced age solely using SB leads to similar csPCA detection rates. Thus, a reduced biopsy protocol may be considered for these men in case resources are limited.
Methods for the optimal preservation of blow fly intra-puparial forms for morphological analysis in forensic casework
Authors: López-García Jaime , Piña Mario A. , Clark Brett , Hall Martin J. R. , Martín-Vega Daniel 
Published: February 2024

AbstractAccurate minimum post-mortem interval (minPMI) estimations often rely on a precise age determination of insect developmental stages, which is significantly influenced by environmental temperature. An optimal preservation of the entomological samples collected at crime scenes is pivotal for a reliable aging of immature insect samples. For blow flies (Diptera: Calliphoridae), the most widely used insect indicators in forensic investigations, an appropriate preservation of tissues is particularly important in the case of puparial samples because aging methods for intra-puparial forms usually depend on morphological analyses; however, although informative soft tissues and structures could be discoloured and/or distorted if they are not properly fixed, there is a lack of studies to assess different methods for the optimal preservation of intra-puparial forms collected in forensic investigations. The present study compares three preservation methods for intra-puparial forms of the blow fly Calliphora vicina Robineau-Desvoidy, 1830: (i) direct immersion into 80% ethanol, (ii) puncturing of the puparium and hot water killing (HWK) prior to preservation in 80% ethanol, and (iii) HWK without puncturing before preservation in 80% ethanol. External and internal morphological analyses of intra-puparial forms of different ages were conducted to assess the quality of preservation. The results indicate that direct immersion in ethanol led to poor preservation, affecting both external and internal tissues. Both methods with HWK resulted in a better preservation, but puncturing resulted, in some cases, in physical damage of the specimens. HWK without puncturing emerged as the optimal preservation method, consistently yielding high preservation scores for both external and internal morphological analyses. These findings have practical implications for forensic practitioners and emphasise the need for updating some published guidelines and protocols in forensic entomology.
Spatial expression of claudin 18.2 in matched primaries and metastases of tubo-ovarian carcinoma of all subtypes
Authors: Wagner Paul , Gass Paul , Pöschke Patrik , Eckstein Markus , Gloßner Laura , Hartmann Arndt , Beckmann Matthias Wilhelm , Fasching Peter Andreas , Ruebner Matthias , Emons Julius , Erber Ramona 
Published: February 2024

AbstractPhysiologically, claudin 18 splice variant 2 (CLDN18.2) expression is restricted to the gastric epithelium, but its expression has been detected in solid cancers. Zolbetuximab, a chimeric IgG1 antibody targeting CLDN18.2, has demonstrated promising effects in patients suffering from CLDN18.2-positive, HER2-negative locally advanced gastric cancer and is currently being studied further. To date, little is known about CLDN18.2 expression in other histological subtypes of tubo-ovarian carcinoma (TOC) and their matching metastases.Using a cohort of all histological TOC subtypes, we investigated the immunohistochemical (IHC) CLDN18.2 expression in both TOCs (n = 536), their matching metastatic tissue (n = 385) and in 93 metastases without primary. Tissue microarrays comprised both the tumor center and periphery. IHC positivity was defined as biomarker expression of ≥ 75% in tumor cells with moderate-to-strong membranous staining.Overall CLDN18.2 positivity was 4.1% (21/515) in the TOC centers and 3.6% (18/498) in their peripheries. In primaries of mucinous tubo-ovarian carcinoma (MTOC), CLDN18.2 positivity rates were 45% (18/40) and 36.6% (15/41), respectively. Positivity rates for the corresponding metastases were 33% (4/12, center) and 27% (3/11, periphery). The expression was relatively homogenous throughout all tumor sites. With no expression in 99.5% of nonmucinous tumors, CLDN18.2 positivity was almost exclusively seen in the mucinous subtype.In tubo-ovarian carcinoma, CLDN18.2 expression was, with rare exceptions, restricted to the mucinous subtype. Among them, 33% of metastasized MTOCs presented with CLDN18.2 positivity. Hence, CLDN18.2 might display a promising target for personalized therapy in patients with advanced MTOC.
Identification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses
Authors: Kim Hyo-Jin , Park Jun-Gyu , Moon Kyeong-Seo , Jung Su-Bin , Kwon Yong Min , Kang Nam Seon , Kim Jeong-Hyeon , Nam Sang-Jip , Choi Grace , Baek Yeong-Bin , Park Sang-Ik 
Published: February 2024

AbstractDespite significant improvements in vaccines and chemotherapeutic drugs, pathogenic RNA viruses continue to have a profound impact on the global economy and pose a serious threat to animal and human health through emerging and re-emerging outbreaks of diseases. To overcome the challenge of viral adaptation and evolution, increased vigilance is required. Particularly, antiviral drugs derived from new, natural sources provide an attractive strategy for controlling problematic viral diseases. In this antiviral study, we discovered a previously unknown bacterium, Mameliella sp. M20D2D8, by conducting an antiviral screening of marine microorganisms. An extract from M20D2D8 exhibited antiviral activity with low cytotoxicity and was found to be effective in vitro against multiple influenza virus strains: A/PR8 (IC50 = 2.93 µg/mL, SI = 294.85), A/Phil82 (IC50 = 1.42 µg/mL, SI = 608.38), and B/Yamagata (IC50 = 1.59 µg/mL, SI = 543.33). The antiviral action was found to occur in the post-entry stages of viral replication and to suppress viral replication by inducing apoptosis in infected cells. Moreover, it efficiently suppressed viral genome replication, protein synthesis, and infectivity in MDCK and A549 cells. Our findings highlight the antiviral capabilities of a novel marine bacterium, which could potentially be useful in the development of drugs for controlling viral diseases.
Unveiling rupture risk and clinical outcomes in midline aneurysms: A matched cohort analysis investigating the impact of localization within the anterior or posterior circulation
Authors: Swiatek Vanessa M. , Amini Amir , Sandalcioglu Ortuño Celina E. , Spitz Lena , Hartmann Karl , Rashidi Ali , Stein Klaus-Peter , Saalfeld Sylvia , Sandalcioglu I. Erol , Neyazi Belal 
Published: February 2024

AbstractIntracranial aneurysms (IAs) located in the anterior and posterior circulations of the Circle of Willis present differential rupture risks. This study aimed to compare the rupture risk and clinical outcomes of anterior communicating artery aneurysms (AcomA) and basilar tip aneurysms (BAs); two IA types located along the midline within the Circle of Willis. We retrospectively collected data from 1026 patients presenting with saccular IAs. Only AcomA and BAs with a 3D angiography were included. Out of 186 included IAs, a cohort of 32 BAs was matched with AcomA based on the patients’ pre-existing conditions and morphological parameters of IAs. Clinical outcomes, including rupture risk, hydrocephalus development, vasospasm incidence, and patients’ outcome, were compared. The analysis revealed no significant difference in rupture risk, development of hydrocephalus, need for ventricular drainage, or vasospasm incidence between the matched AcomA and BA cohorts. Furthermore, the clinical outcomes post-rupture did not significantly differ between the two groups, except for a higher Fisher Grade associated with BAs. Once accounting for morphological and patient factors, the rupture risk between AcomA and BAs is comparable. These findings underscore the importance of tailored management strategies for specific IA types and suggest that further investigations should focus on the role of individual patient and aneurysm characteristics in IA rupture risk and clinical outcomes.
Time budget of a mallard duck population residing in an urban park in northern Portugal during courtship and nesting period
Authors: Santos Luís Eduardo , de Sousa Liliana , Magalhães Ana 
Published: February 2024

AbstractBehavioural observations were used to investigate the temporal dynamics events and associated variation in the daily activities of a sedentary population of mallard duck (Anas platyrhynchos) inhabiting an urban park in northern Portugal. Data was collected at Porto City Park from December to April, during the species’ courtship and early nesting periods. The most frequent activities for this population were locomotion, resting and feeding. Statistical analysis revealed that male and female behaviours differed significantly throughout the courtship period, as males exhibited more displays and aggressive behaviour while females were more prone to feed in order to meet their increased nutritional and energetic needs. Temporal analyses showed that courtship reached a peak in intensity in February, since it was in this month that the highest values for mating, aggressive behaviour in males and defensive behaviour in females were observed. Behavioural differences were found for this population, with higher feeding rates compared to those of wild populations as well as lower defensive behaviour rates. This paper sheds light on how synanthropized populations, as well as those from Southwestern Europe, show different behavioural responses from other populations. Additional extensive monitoring of population dynamics and factors such as latitudinal differences, habituation to humans and climate change will help to predict future growth and expansion rates.
Uniaxial mechanical stretch properties correlated with three-dimensional microstructure of human dermal skin
Authors: Zhou Mengyao , González Patrick José , Van Haasterecht Ludo , Soylu Alperen , Mihailovski Maria , Van Zuijlen Paul , Groot Marie Louise 
Published: February 2024

AbstractThe intact and healthy skin forms a barrier to the outside world and protects the body from mechanical impact. The skin is a complex structure with unique mechano-elastic properties. To better direct the design of biomimetic materials and induce skin regeneration in wounds with optimal outcome, more insight is required in how the mechano-elastic properties emerge from the skin’s main constituents, collagen and elastin fibers. Here, we employed two-photon excited autofluorescence and second harmonic generation microscopy to characterize collagen and elastin fibers in 3D in 24 human dermis skin samples. Through uniaxial stretching experiments, we derive uni-directional mechanical properties from resultant stress-strain curves, including the initial Young’s modulus, elastic Young’s modulus, maximal stress, and maximal and mid-strain values. The stress-strain curves show a large variation, with an average Young’s modules in the toe and linear regions of 0.1 MPa and 21 MPa. We performed a comprehensive analysis of the correlation between the key mechanical properties with age and with microstructural parameters, e.g., fiber density, thickness, and orientation. Age was found to correlate negatively with Young’s modulus and collagen density. Moreover, real-time monitoring during uniaxial stretching allowed us to observe changes in collagen and elastin alignment. Elastin fibers aligned significantly in both the heel and linear regions, and the collagen bundles engaged and oriented mainly in the linear region. This research advances our understanding of skin biomechanics and yields input for future first principles full modeling of skin tissue.
Predatory preferences of a non-indigenous crab do not depend on prey invasion scenarios
Authors: Theurich Nora , Briski Elizabeta , Cuthbert Ross N. 
Published: February 2024

AbstractPredatory non-indigenous species (NIS) have profound impacts on global ecosystems, potentially leading to native prey extinction and reshaping community dynamics. Among mechanisms potentially mediating predator impacts and prey invasion success are predator preferences between native vs. non-indigenous prey, a topic still underexplored. Using functional response and prey preference experiments, this study focused on the predation by the non-indigenous Japanese brush-clawed shore crab, Hemigrapsus takanoi, between the native gammarid Gammarus duebeni and the analogous non-indigenous Gammarus tigrinus. Although H. takanoi showed subtle differences in its functional response type between the two prey species, its preferences across their environmental frequencies were not strongly influenced by the prey invasion scenario. The findings highlight the need for a comprehensive understanding of interactions in ecosystems with multiple NIS, offering fresh insights into complex feeding interactions within marine environments.
Climate projections of human thermal comfort for indoor workplaces
Authors: Sulzer Markus , Christen Andreas 
Published: February 2024

AbstractClimate models predict meteorological variables for outdoor spaces. Nevertheless, most people work indoors and are affected by heat indoors. We present an approach to transfer climate projections from outdoors to climate projections of indoor air temperature (Ti) and thermal comfort based on a combination of indoor sensors, artificial neural networks (ANNs), and 22 regional climate projections. Human thermal comfort and Ti measured by indoor sensors at 90 different workplaces in the Upper Rhine Valley were used as training data for ANN models predicting indoor conditions as a function of outdoor weather. Workplace-specific climate projections were modeled for the time period 2070–2099 and compared to the historical period 1970–1999 using the same ANNs, but ERA5-Land reanalysis data as input. It is shown that heat stress indoors will increase in intensity, frequency, and duration at almost all investigated workplaces. The rate of increase depends on building and room properties, the workplace purpose, and the representative concentration pathway (RCP2.6, RCP4.5, or RCP8.5). The projected increase of the mean air temperature in the summer (JJA) outdoors, by + 1.6 to + 5.1 K for the different RCPs, is higher than the increase in Ti at all 90 workplaces, which experience on average an increase of + 0.8 to + 2.5 K. The overall frequency of heat stress is higher at most workplaces than outdoors for the historical and the future period. The projected hours of indoor heat stress will increase on average by + 379 h, + 654 h, and + 1209 h under RCP2.6, RCP4.5, and RCP8.5, respectively.
CXCR2 antagonist navarixin in combination with pembrolizumab in select advanced solid tumors: a phase 2 randomized trial
Authors: Armstrong Andrew J. , Geva Ravit , Chung Hyun Cheol , Lemech Charlotte , Miller Wilson H. , Hansen Aaron R. , Lee Jong-Seok , Tsai Frank , Solomon Benjamin J. , Kim Tae Min , Rolfo Christian , Giranda Vincent , Ren Yixin , Liu Fang , Kandala Bhargava , Freshwater Tomoko , Wang Judy S. 
Published: February 2024

SummaryC-X-C motif chemokine receptor 2 (CXCR2) has a role in tumor progression, lineage plasticity, and reduction of immune checkpoint inhibitor efficacy. Preclinical evidence suggests potential benefit of CXCR2 inhibition in multiple solid tumors. In this phase 2 study (NCT03473925), adults with previously treated advanced or metastatic castration-resistant prostate cancer (CRPC), microsatellite-stable colorectal cancer (MSS CRC), or non–small-cell lung cancer (NSCLC) were randomized 1:1 to the CXCR2 antagonist navarixin 30 or 100 mg orally once daily plus pembrolizumab 200 mg intravenously every 3 weeks up to 35 cycles. Primary endpoints were investigator-assessed objective response rate (RECIST v1.1) and safety. Of 105 patients (CRPC, n=40; MSS CRC, n=40; NSCLC, n=25), 3 had a partial response (2 CRPC, 1 MSS CRC) for ORRs of 5%, 2.5%, and 0%, respectively. Median progression-free survival was 1.8–2.4 months without evidence of a dose-response relationship, and the study was closed at a prespecified interim analysis for lack of efficacy. Dose-limiting toxicities occurred in 2/48 patients (4%) receiving navarixin 30 mg and 3/48 (6%) receiving navarixin 100 mg; events included grade 4 neutropenia and grade 3 transaminase elevation, hepatitis, and pneumonitis. Treatment-related adverse events occurred in 70/105 patients (67%) and led to treatment discontinuation in 7/105 (7%). Maximal reductions from baseline in absolute neutrophil count were 44.5%−48.2% (cycle 1) and 37.5%−44.2% (cycle 2) and occurred within 6−12 hours postdose in both groups. Navarixin plus pembrolizumab did not demonstrate sufficient efficacy in this study. Safety and tolerability of the combination were manageable. (Trial registration: ClinicalTrials.gov, NCT03473925).