bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and transcriptomic analyses of diffuse large B-cell lymphoma patients with poor outcomes within two years of diagnosis
Authors: Ren Weicheng , Wan Hui , Own Sulaf Abd , Berglund Mattias , Wang Xianhuo , Yang Mingyu , Li Xiaobo , Liu Dongbing , Ye Xiaofei , Sonnevi Kristina , Enblad Gunilla , Amini Rose-Marie , Sander Birgitta , Wu Kui , Zhang Huilai , Wahlin Björn Engelbrekt , Smedby Karin E. , Pan-Hammarström Qiang 
Published: December 2023

AbstractDespite the improvements in clinical outcomes for DLBCL, a significant proportion of patients still face challenges with refractory/relapsed (R/R) disease after receiving first-line R-CHOP treatment. To further elucidate the underlying mechanism of R/R disease and to develop methods for identifying patients at risk of early disease progression, we integrated clinical, genetic and transcriptomic data derived from 2805 R-CHOP-treated patients from seven independent cohorts. Among these, 887 patients exhibited R/R disease within two years (poor outcome), and 1918 patients remained in remission at two years (good outcome). Our analysis identified four preferentially mutated genes (TP53, MYD88, SPEN, MYC) in the untreated (diagnostic) tumor samples from patients with poor outcomes. Furthermore, transcriptomic analysis revealed a distinct gene expression pattern linked to poor outcomes, affecting pathways involved in cell adhesion/migration, T-cell activation/regulation, PI3K, and NF-κB signaling. Moreover, we developed and validated a 24-gene expression score as an independent prognostic predictor for treatment outcomes. This score also demonstrated efficacy in further stratifying high-risk patients when integrated with existing genetic or cell-of-origin subtypes, including the unclassified cases in these models. Finally, based on these findings, we developed an online analysis tool (https://lymphprog.serve.scilifelab.se/app/lymphprog) that can be used for prognostic prediction for DLBCL patients.
Reimagining From Abroad: Speech-Language Pathologists as Interprofessional Partners Supporting Justice-Involved Youth in America
Authors: Perrotti Anne Marie , Martinez Sophia Janeiro , Chappell Allison , Baker Brooke D. , Jayarathna Sampath 
Published: December 2023

Purpose:With application to the United States, this tutorial explores barriers in the American juvenile justice system for justice-involved youth (JIY) with cognitive-communication disorders (CCDs). It outlines models from abroad and reimagines the American juvenile justice system to include speech-language pathologists (SLPs) as interprofessional practice partners.Method:Interprofessional (i.e., criminal justice, speech-language pathology) literature from the United States and overseas is reviewed and summarized to explain the American juvenile justice system, outline areas of concern for youth with CCDs, and describe potential solutions.Results:The application of speech-language pathology services within the juvenile justice system is explained and visually depicted. This framework was informed by intervention models and approaches from international examples.Conclusions:There is an opportunity to embed speech-language pathology services from intake into court action and through disposition for JIY with cognitive-communication impairments. This includes interprofessional education and development, SLPs providing direct intervention, and multidisciplinary screening efforts. Speech-language pathologists as interprofessional advocates and practice partners can improve life chances and outcomes for youth with CCDs in the juvenile justice system.
DC protection coordination for multi‐terminal HB‐MMC‐based HVDC grids
Authors: Ashrafi Niaki Seyed Hassan , Chen Zhe , Bak‐Jensen Birgitte , Sharifabadi Kamran , Liu Zhou , Hu Shuju 
Published: December 2023

AbstractFast progress of High Voltage Direct Current (HVDC) technology has been considerable over the past decades. Emerging Modular Multilevel Converter (MMC) provides power systems with promising solutions to integrate large‐scale renewable energy sources, as well as multiple asynchronous power grids. Consequently, implementation of a multi‐terminal HVDC transmission system has been easier using MMC converters. However, protection of multi‐terminal MMC‐based HVDC grids under DC fault conditions is a challenge for the industry. This study sheds light on concept of system‐level DC protection coordination for multi‐terminal HVDC grids. Although, there are different protection methods for HVDC transmission systems including multi‐terminal ones, there are no well‐defined protection coordination strategies for transmission links protection and belonging HVDC converters under DC fault conditions. The proposed protection coordination prevents unnecessary tripping of MMCs in the multi‐area HVDC grids and supports the system with minimum effect on healthy parts. For the first time, different HVDC Converter Tripping (HCT) profiles are presented based on a fully selective protection strategy and their characteristics are discussed comprehensively. Simulation results demonstrate the effectiveness of the proposed strategy for multi‐terminal MMC‐based HVDC grids. The proposed coordination can be applied to DC grid code requirements of meshed HVDC grids in the future.
Havana, Moscow and international crises: implications for asymmetry
Authors: Bain Mervyn J. 
Published: December 2023

AbstractAsymmetric relationships are key to international relations with Russia’s February 2022 invasion of Ukraine placing asymmetry at the forefront of global politics. This article’s originality arises from its examination of the effects of an international crisis involving the larger partner of an asymmetric relationship and a third-party country for the asymmetric relationship in question. Specifically, Havana–Moscow relations. Havana’s response to the August 1968 invasion of Czechoslovakia, the December 1979 invasion of Afghanistan and the 2022 Ukrainian invasion are examined using a rigorous historical qualitative analysis of primary and secondary sources and a qualitative and quantitative analysis of bilateral trade. It is posited that during an international crisis: (1) the dynamics of the asymmetric relationship change triggering a new type of asymmetry: temporal crisis asymmetry; and (2) the bilateral relationship becomes more symmetric. Significant for other asymmetric relationships impacted by an international crisis involving the larger partner and a third-party country.
Origins of multi-sublattice magnetism and superexchange interactions in double–double perovskite CaMnCrSbO6
Authors: Dhawan Rakshanda , Balasubramanian Padmanabhan , Nautiyal Tashi 
Published: December 2023

Abstract
The multi-sublattice magnetism and electronic structure in double–double perovskite compound CaMnCrSbO6 is explored using density functional theory. The bulk magnetization and neutron diffraction suggest a ferrimagnetic order (

T

C

∼

49 K) between between Mn2+ and Cr3+ spins. Due to the non-equivalent Mn atoms (labelled as Mn(1) and Mn(2) which have tetrahedral and planar oxygen coordinations, respectively) and the Cr atom in the centre of distorted oxygen octahedron in the unit cell, the exchange interactions are more complex than that expected from a two sublattice magnetic system. The separations between the on-site energies of the d-orbitals of Mn(1), Mn(2) and Cr obtained from Wannier function analysis are in agreement with their expected crystal field splitting. While the DOS obtained from non spin-polarized calculations show a metallic character, starting from Hubbard U = 0 eV the spin-polarized electronic structure calculations yield a ferrimagnetic insulating ground state. The band gap increases with

U
eff

(U − J), thereby showing a Mott–Hubbard nature of the system. The inclusion of anti-site disorder in the calculations show decrease in band-gap and also reduction in the total magnetic moment. Due to the ∼90∘ superexchange, nearest neighbour exchange constants obtained from DFT are an order of magnitude smaller than those reported for various magnetic perovskite and double-perovskite compounds. The Mn(1)–O–Mn(2) (out of plane and in-plane), Mn(1)–O–Cr and Mn(2)–O–Cr superexchange interactions are found to be anti-ferromagnetic, while the Cr–O–O–Cr super-superexchange is found to be ferromagnetic. The Mn(2)–O–Cr superexchange is weaker than the Mn(1)–O–Cr super-exchange, thus effectively resulting in ferrimagnetism. From a simple 3-site Hubbard model, we derived expressions for the antiferromagnetic superexchange strength

J
AFM

and also for the weaker ferromagnetic

J
FM

. The relative strengths of

J
AFM

for the various superexchange interactions are in agreement with those obtained from DFT. The expression for Cr–O–O–Cr super-superexchange strength (

J
~

SS

), which has been derived considering a 4-site Hubbard model, predicts a ferromagnetic exchange in agreement with DFT. Finally, our mean field calculations reveal that assuming a set of four magnetic sub-lattices for Mn2+ spins and a single magnetic sublattice for Cr3+ spins yields a much improved T

C
, while a simple two magnetic sublattice model yields a much higher T

C
.
Constraints on the primordial curvature power spectrum by pulsar timing array data: a polynomial parameterization approach
Authors: Fei Qin 
Published: December 2023

Abstract
The recent stochastic signal observed jointly by NANOGrav, parkes pulsar timing array, European pulsar timing array, and Chinese pulsar timing array can be accounted for by scalar-induced gravitational waves (SIGWs). The source of the SIGWs is from the primordial curvature perturbations, and the main contribution to the SIGWs is from the peak of the primordial curvature power spectrum. To effectively model this peak, we apply the Taylor expansion to parameterize it. With the Taylor expansion parameterization, we apply Bayesian methods to constrain the primordial curvature power spectrum based on the NANOGrav 15 year data set. The constraint on the primordial curvature power spectrum possesses a degree of generality, as the Taylor expansion can effectively approximate a wide range of function profiles.
Categorization of handedness based on daily activity and hand strength performance in Sumatran society
Authors: Muktiono P , Putri I A , Badriah N , Nurhayu W , Darmawan A , Mulyana J S , Maretta G , Widayati K A 
Published: December 2023

Abstract
Handedness is an individual’s preference to use one hand performing activities such as cutting with a knife or writing. Handedness is divided into two, right-handed and left-handed. Handedness can be influenced by genetics, prenatal development, and parenting. This study aims to analyse the categorization of handedness based on self-confessed, 10 daily uni-manual activities and hand strength performance. This study was conducted for 1 month by visiting a crowd of more than two people and providing a consent sheet following the questionnaire, personal data questionnaire including sex and age, 10 daily activity questionnaires and power grip questionnaires accompanied by power grip measurements using a dynamometer. A total of 610 individuals were assessed. The study showed that handedness could be determined by assessing self-confessed, 10 daily uni-manual activities with addition of hand strength performance. The older a person was the stronger the power grip value, those with a right-handed preference had a greater right handgrip value. Age was found did not affect handedness.
Investigating the patterns of simple sequence repeats (SSRs) inferred from the whole genome of a critically endangered species Cassine koordersii kosterm
Authors: Husaini I P A , Rinandio D S , Martiansyah I , Magandhi M , Suhatman A , Irsyam A S D , Irwanto R R , Setiawan E , Hariri M R 
Published: December 2023

Abstract

Cassine koordersii Kosterm. (Celastraceae) is a critically endangered species indigenous to Jember, East Java. Programs for genetic conservation and plant breeding have recently implemented next-generation sequencing (NGS) techniques based on genomic data. This research aims to explore and distinguish between perfect and imperfect SSR patterns in the assembled genome. The Abyss assembler produced 3,060,362 scaffolds with 35.63 % GC content for the assembled genome. The investigation and identification of SSRs using the Krait tool found 139,236 and 582,360 sequences for including perfect and imperfect SSRs, respectively. There were six motif repeats of perfect and imperfect SSRs consisting of 73,175 and 202,438 sequences of mononucleotide (the most motif was A); 17,179 and 65,705 sequences of dinucleotide (the most motif was AT); 5,175 and 51,948 sequences of trinucleotide (the most motif was AAT); 3,824 and 14,010 sequences of tetranucleotide (the most motif was AAAT); 659 and 3,082 sequences of pentanucleotide (the most motif is AAAAT); 118 and 757 sequences of hexanucleotide (the most motif is AAAAAT). The depicted perfect and imperfect SSRs markers can be employed in future genetic studies of Cassine and related genera for either recommendation effort or improvement in conservation genetic concerns.
Yeast diversity isolated from nypa palm leaf litter in the macrohabitat of the nypa palm worm (Namalycastis rhodochorde)
Authors: Kurniatuhadi R , Setyawati T R , Yanti A H , Batua B 
Published: December 2023

Abstract
Yeasts are known to have broad and specific enzymatic activity, including cellulolytic activity. The diversity of yeast in the nypa palm mangrove area is thought to have a role in the organic degradation process of nypa leaf litter which supports the fermentation of nypa palm worm feed. This study aims to determine the composition and genera of yeast present in the habitat of nypa palm worms. The sampling process was determined using a purposive sampling method in Sungai Kakap Village, Kubu Raya Regency, West Kalimantan. Isolation was carried out using the pour plate method with serial dilution on the Saboraud Dextrose Agar Medium (SDA). The process of characterizing yeast genera was determined by observing the characteristics of microcolonies, type of budding cells, presence of pseudohyphae, type and number of spores, ascospore, and capsule presence. The results showed that the composition of the successfully isolated yeast was 11% of the total colonies growing on the SDA medium. Isolates NrYS1 and NrYS4 are similar to Torulaspora, while isolates NrYS2 and NrYS3 are similar to Schizosaccharomyces. Further research is needed on the potential of the four enzymatic yeasts to be used as probiotic feed for the nypa palm worm’s culture.
The conservation of wild species banana (Musa velutina H.Wendl. & Drude) through seed germination technology
Authors: Puspitaningtyas D M , Agustin E K , Wanda I F , Zanzibar M , Sahromi  , Latifah D , Widjaya A H 
Published: December 2023

Abstract

Musa velutina H. Wendl. & Drude is a member of the Musaceae family, which is known as the pink velvet banana. This species has problems with seed germination. The seed coat has a hard layer of the outer integument that inhibits the germination process. This study aimed to determine the effect of the soaking time at various soaking media of the seven treatments on the seed germination of M. velutina. The method used a completely randomized design with seven treatments and three replications. The seeds were collected from a fruit bunch of M. velutina in Bogor Botanic Gardens. The number of seeds was 10 for each treatment. The treatments in this study were scarification by seed wounds, soaking seeds in 1% H2O2 and 5% H2O2 for four days, soaking seeds in hot water at 60°C and 80°C for 1 hour, soaking seeds in water for 24 hours and 72 hours. Then, as a control, the fresh seeds were sowed directly without treatment. The results showed that soaking in water for 24 hours was the best method for the early emergence of sprouts, the percentage of germination rate, the coefficient of germination rate, and the coefficient of simultaneous germination.
Epibiont of venus clam (Gafrarium tumidum) shells: a study on Pari Island, Seribu Islands
Authors: Cintra A K A , Firdaus M R , Fitriya N , Rachman A 
Published: December 2023

AbstractMolluscs play a crucial role as ecosystem engineer by providing habitat for other organisms. However, little is known about the shells’ ability to host other species, especially in tropical ecosystems like Pari Island. In sandy locations, hard substrates are scarce, but clam shells introduce substrate heterogeneity. Our study focused on the Venus Clam(Gafrarium tumidum), prevalent in the seagrass bed ecosystem on Pari Island, to explore the epibiont species residing on its shells. Epibionts were examined through visual observation and microscopy analysis in a laboratory. We found the attached epibionts were categorized into three main groups. The first group was macroalgae, specificallyPadinasp., which attached to the posterior part of the clam shell, relying on stable substrates to withstand waves. The second group encompassed microalgae, includingBacillaria, Nitzchia, Prorocentrum, Pseudo-nitzschia, Surirella, andTrichodesmium. These microalgae have diverse ecological roles, including causing harmful algal blooms and nitrogen fixation. The third group consisted of possibly cyanobacteria forming blue-green biofilms on clam shells, predominantly on recently deceased or living clams, mainly in exposed, sunlit areas. This research emphasizes the significant role of clam shells in supporting epibiont species richness in the ecosystem.
Plant growth promoting rhizobacteria exploration on butterfly pea (Clitoria ternatea l) from North Maluku Indonesia
Authors: Nurhasanah  , Papuangan N , Sundari  , Lestari D A , Siswanto A E , Hindersah R , Suganda T , Karuniawan A 
Published: December 2023

Abstract
The Plant Growth Promoting Rhizobacteria (PGPR) is associated with the roots and nodules of butterfly peas (Clitoria ternatea L.). This study aims to explore the PGPR in the rhizosphere of butterfly peas and to study their potential for biofertilizer. Characterization of PGPR was based on their ability to phosphate dissolution, auxin production, and nitrogen fixation as well as synergistic and antagonistic tests, and molecular identification. A total of 11 phosphate solubilizing bacteria isolates were isolated from the rhizosphere of butterfly peas while two isolates were taken from nodules. The RTF2 isolate from the rhizosphere had the highest phosphate solubility index. Meanwhile, the RTDH5-1, F1.1, and F2.1 showed strong inhibition ability against the growth of the pathogenic Rhizoctonia solani. The nitrogenase activity of isolates F2.1 and F1.1 from nodules were 0.975 μmol mL-1 g-1 h-1; while the IAA production was 7.87 and 7.05 mg L-1, respectively. The F1.1 had 100% similarity with Bacillus aryabhattai while F2.1 was 99.84% similar with Rhizobium sp. Both isolates can be used in biofertilizer formulation for North Maluku butterfly peas.
Morphometric differentiation of Landouria smimensis along altitudinal gradient
Authors: Nurhayati P A , Nurinsiyah A S , Atmowidi T , Priawandiputra W 
Published: December 2023

AbstractLandouria smimensisis an endemic land snail found in the Mount Semeru area. This species can be found in different altitudes of Mount Semeru. The study aimed to analyze the morphometric ofL. smimensisshells along the altitudinal gradient of Mount Semeru. Samples were taken from four altitudinal gradients of Mount Semeru from October 2021 to June 2022. In total, 114 individuals ofL. smimensiswere measured based on shell morphology characters. The characters were the height and diameter of the shell, the height and diameter of the aperture, the diameter of the first three whorl, and the number of whorls. Shell morphometric was measured using ImageJ and analyzed using PAST. Most shell morphology characters showed the differentiation among the altitudinal gradient (p<0.05), except between 1601-2000 m asl and 2001-2400 m asl (p>0.05). The shell morphology characters from the population below 1200 m asl are significantly the biggest than population from others altitudes. Most shell morphology characters negatively correlated with the altitude. It is known that the shell morphometric characters of the shells can be a differentiates among populations ofL. smimensisat each altitude.
The estimated carbon stored in Underutilized Fruit Trees (UFTs) collection of Cibodas and Cibinong Botanic Gardens
Authors: Yulizah  , Rahajoe J S , Jakalalana S , Oksari A A , Yuliani N 
Published: December 2023

Abstract
Trees are the largest carbon stores in tropical forests, where each species has different biomass and carbon sequestration. Information on biodiversity potential is essential for the conservation of endangered species, especially underutilized species, such as Underutilized Fruit Trees (UFTs). These UFTs were collected from various regions in Indonesia, representing trees that generally grow in lowland to mountain forest ecosystems, then these trees were replanted in Cibodas Botanic Gardens and Cibinong Botanic Gardens as living collection. This research aims to determine the role of UFT in ecosystem function as carbon storage. Sampling carried out using a purposive sampling method to determine the UFT species. The allometric equations is used to determine biomass, while to determine carbon content the UFT species analysis using C/N analyzer. The research result show that the highest potential for carbon storage and absorption is found in Castanopsis argentea, while Eugenia uniflora wood has the highest carbon content, namely 45.86%. Syzygium pycnanthum wood has the lowest carbon content (35.76%). Considering the highest potential of UFT as a carbon stock, information about other species of UFTs is important for determining carbon in modelling carbon trading, since this species is widely cultivated on agroforestry land.
DNA barcoding application for potential medicinal plants on Ziziphus species from Aketajawe-Lolobata National Park, North Moluccas
Authors: Arifiani D , Sulistyaningsih L D , Martiansyah I , Tamnge F , Sahroni D 
Published: December 2023

Abstract
Aketajawe-Lolobata National Park is a protected national park located in the province of North Moluccas, Indonesia. The national park has been known to be rich in biodiversity with the existence of many potential medicinal plants such as Ziziphus. DNA barcoding can be a useful tool for identifying and characterizing these plants for potential medical applications. Research and exploration have been conducted in Aketajawe-Lolobata National Park in November and December 2022. This study aimed to analyze how the DNA barcoding regions aid identification for potential medicinal plants. The genomic DNA were amplified by matK primers, and the sequences showed high similarity rate with their homologs, then the phylogenetic tree was constructed using the Neighbor-Joining method to assess their cross-species relationship. The phylogenetic study showed that the species that have been identified based on morphological characters, i.e., Ziziphus angustifolia and Z. mauritiana were clustered with Z. angustifolia and Z. mauritiana retrieved from GenBank. However, the unidentified species are closely related with Z. calophylla obtained from GenBank but with low bootstrap support. All the results indicate that DNA barcoding approach could be successfully used for reliable identification of medicinal plants and matK gene is a good candidate for this approach.