bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling metabolic flux changes during acute cold exposure
Authors: Tang Pingping , Xu Henghui , Zhang Yong 
Published: January 2024

Abstract
Controlling energy expenditure during acute cold exposure is a fundamental aspect of metabolic dynamics in organisms. However, prior studies on cold-induced thermogenesis faced limitations, primarily focusing on brown adipose tissue (BAT) and lacking precise in vivo flux measurements. This editorial aims to highlight the recent research by Bornstein et al. providing a comprehensive and quantitative insight into the intricate alterations in metabolic flux that drive this phenomenon[1].
Research progress on the role of cold-sensitive channel TRPM8 in controlling low temperature-induced bone metabolic imbalance
Authors: Zhang Yimeng , Kazakova E. V , Chai Huijuan , Zhou Ping 
Published: January 2024

Abstract
With increasing aging population, osteoporosis has emerged as a public health problem worldwide. Epidemiological data reveal that the prevalence of osteoporosis in cold regions is high, and low temperatures may crucially affect bone mass. Recent studies have found that the transient receptor potential melastatin-8 (TRPM8) channel, a cold-sensitive ion channel, can sense cold environment, and can be activated in cold environment. It may play an antagonistic role in low temperature-induced bone mass reduction. Mechanistically, this function may be ascribed to the activation of TRPM8 channel proteins in human bone marrow mesenchymal stem cells (hBM-MSCs), which causes osteoblast differentiation and mineralization in the bone. TRPM8 channel on the surface of brown adipocytes participates in the thermogenesis in brown adipose tissue (BAT) and the regulation of whole-body energy balance to maintain bone homeostasis. TRPM8 may be involved in bone remodeling throughout life. This paper reviews recent research on the possible antagonistic mechanism of TRPM8 in signaling pathways related to low temperature-induced bone mass loss and assesses the possibility of TRPM8 as a molecular target for the prevention and treatment of low temperature-induced osteoporosis in cold regions.
Advancements in understanding inflammatory responses and the development of cardiovascular diseases under cold stimulation
Authors: Ma Guanpeng , Cai Hengxuan , Li Zhaoying , Lu Rongzhe , Yu Bo , Fang Shaohong 
Published: January 2024

Abstract
Cold stimulation has been linked to acute myocardial infarction and other cardiovascular diseases. Residents in the frigid zones, such Heilongjiang Province, experience a higher incidence of adverse cardiovascular events during winter, posing a significant health threat and increasing the overall medical burden. Cold stimulation serves as an detrimental stressor, inducing inflammation in the body. Therefore, understanding the role of inflammatory responses induced by cold stimulation in the occurrence and development of cardiovascular diseases is of paramount importance. Given the impact of cold on inflammation in cardiovascular diseases and the expanding array of anti-inflammatory methods for the treatment of cardiovascular diseases, delving into the inflammatory responses mediated by can significantly complement cardiovascular disease management. This review explorest the synergistic relationship between cold stimulation and inflammation induction, elucidating how this interplay influences the occurrence and progression of cardiovascular diseases.
Cold exposure promotes coronavirus infection by altering the gut microbiota and lipid metabolism to reduce host immunity
Authors: Wu Gaosong , Zhang Yuhao , Zheng Ningning , Tian Saisai , Liao Jingyu , Le Wanqi , Li Houkai , Zhang Weidong 
Published: January 2024

Abstract

Objective
Cold exposure has been suggested to be advantageous for the spread and infection of the coronavirus, and the gut microbiota influences the severity of the infection by modulating host inflammatory and immune responses. However, it remains unclear whether the promotion of viral infection through cold exposure is linked to the gut microbiota.

Methods
In this study, we performed an unbiased analysis of gut microbiota, serum, and lung tissue metabolome changes in cold-exposed and virus-infected mice, alongside the assessment of immune-inflammatory indicators in serum and lung tissue.

Results
The results revealed that both cold exposure and viral infection significantly decreased the percentage of peripheral blood lymphocytes (CD4+ T cells, CD8+ T cells, and B cell) and increased the expression of inflammatory factors (IL-6, IL-1β, TNF-α, and IFN-γ). Meanwhile, cold exposure disrupted the homeostasis of gut microbiota, elevating the abundance of pathogenic bacteria (Staphylococcus) and diminishing the abundance of beneficial bacteria (Alistipes). Notably, in virus-infected mice exposed to a cold environment, the reduction in the abundance of beneficial bacteria Alistipes was more pronounced than in cases of single virus infection and cold exposure. Analysis of altered serum and lung tissue metabolites highlighted glycerophospholipids, fatty acids, and eicosanoids as the most affected metabolites by cold exposure. These metabolites, closely associated with virus infection, exhibited a significant correlation with immune-inflammatory indicators.

Conclusion
These findings establish a mechanistic connection between cold exposure and virus infection, suggesting that cold exposure-induced dysregulation of gut microbiota and lipid metabolism diminishes host immunity, promoting virus infection.
Low ambient temperature and air pollution are associated with hospitalization incidence of coronary artery disease: Insights from a cross-sectional study in Northeast China
Authors: Jiang Rui , Xu Lingling , Liu Yue , Zhao Guangna , Xing Chun , Li Youyuan , Wang Yongchen 
Published: January 2024

Abstract

Background
Previous studies have established a link between fluctuations in climate and increased mortality due to coronary artery disease (CAD). However, there remains a need to explore and clarify the evidence for associations between meteorological changes and hospitalization incidences related to CAD and its subtypes, especially in cold regions. This study aimed to systematically investigate the relationship between exposure to meteorological changes, air pollutants, and hospitalization for CAD in cold regions.

Methods
We conducted a cross-sectional study using hospitalization records of 86,483 CAD patients between January 1, 2009, and December 31, 2019. Poisson regression analysis, based on generalized additive models, was applied to estimating the influence of hospitalization for CAD.

Results
Significant associations were found between low ambient temperature [-10°C, RR = 1.65; 95% CI: (1.28–2.13)] and the incidence of hospitalization for CAD within a lag of 0–14 days. Furthermore, O3 [95.50 μg/m3, RR = 12; 95% CI: (1.03–1.21)] and NO2 [48.70 μg/m3, RR = 1.0895% CI: (1.01–1.15)] levels were identified as primary air pollutants affecting the incidence of CAD, ST-segment-elevation myocardial infarction (STEMI), and non-STEMI (NSTEMI) within the same lag period. Furthermore, O3 [95.50 μg/m3, RR = 1.12; 95% CI: (1.03–1.21)] and NO2 [48.70 μg/m3, RR = 1.0895% CI: (1.01–1.15)] levels were identified as primary air pollutants affecting the incidence of CAD, ST-segment-elevation myocardial infarction (STEMI), and non-STEMI (NSTEMI) within the same lag period. The effect curve of CAD hospitalization incidence significantly increased at lag days 2 and 4 when NO2 and O3 concentrations were higher, with a pronounced effect at 7 days, dissipating by lag 14 days. No significant associations were observed between exposure to PM, SO2, air pressure, humidity, or wind speed and hospitalization incidences due to CAD and its subtypes.

Conclusion
Our findings suggest a positive correlation between short-term exposure to low ambient temperatures or air pollutants (O3 and NO2) and hospitalizations for CAD, STEMI, and NSTEMI. These results could aid the development of effective preparedness strategies for frequent extreme weather events and support clinical and public health practices aimed at reducing the disease burden associated with current and future abnormal weather events.
Shock Wave of Russian Emigration and Self-Reflection of Its Representatives
Authors: Rapoport Eva 
Published: January 2024

This essay introduces the notion of the shock wave of Russian emigration, applicable to those Russian citizens who strongly opposed the outbreak of military aggression against Ukraine and chose to leave Russia within the first weeks of the beginning of the fullscale invasion on February 24, 2022. Based on the data collected from in-depth interviews, the study of the shock wave gives an overview of the spectrum of the respondents’ personal motivations for leaving the country, fears and expectations that were driving them, and their deeper reflection on their experiences where metaphors and imagery play a very prominent role.
Text in English
HUBUNGAN POLA ASUH DEMOKRATIS ORANGTUA DENGAN KEMANDIRIAN SISWA KELOMPOK B TK NEGERI PEMBINA 3 KOTA PEKANBARU
Authors: Afiyah Afiyah , Alucyana Alucyana 
Published: January 2024

Abstract
This study aims to determine the relationship between democratic parenting of parents and the independence of group B students in Binder Kindergarten 3, Marpoyan Damai District, Pekanbaru City. This research was conducted because there were problems in democratic parenting with the independence of group B students. The type of research used is a quantitative approach with a correlational research type. The population of this research is 54 parents. By using a sample census, which means that the entire population will be used as a sample. Data were obtained through a temporary questionnaire for data analysis using normality test analysis, simple linear regression test with the help of SPSS version 14.00 for windows. From the research results, it was found that: the coefficient value of the regression direction between the variables of democratic parenting with the independence of group B students was 0.424 and the significance was t = 0.504. This shows that the variable of democratic parenting at an error rate of 0.05 has a significant effect, and the proposed hypothesis is rejected. The direction of the regression coefficient is positive (+), which means that if the relationship between democratic parenting is better, then the student’s independence will increase by 0.504.
A INTERFERÊNCIA DA PEDAGOGIA DOS MULTILETRAMENTOS NA BNCC DE LÍNGUA PORTUGUESA DO ENSINO FUNDAMENTAL
Authors: Dantas de Melo Justino Rogéria , Marinho Ribeiro Roziane 
Published: January 2024

Neste trabalho, nos propomos a analisar a Base Nacional Comum Curricular (BNCC) de Língua Portuguesa dos Anos Finais do Ensino Fundamental, com foco na proposta dos multiletramentos. Trata-se de um recorte de uma pesquisa de mestrado em andamento. Por se tratar de um estudo ainda em processo de conclusão, apresentaremos no presente artigo os resultados referentes à nossa primeira categoria analítica, que está alicerçada na seguinte questão investigativa: como está caracterizada a proposta de multiletramentos apresentada na BNCC de Língua Portuguesa dos Anos Finais do Ensino Fundamental? Assim, apresentamos uma análise comparativa entre a BNCC e a abordagem da Pedagogia dos Multiletramentos, tomando como foco analítico os textos referentes à seção introdutória (p. 67-86), bem como os campos de atuação (campo artístico-literário, campo das práticas de estudo e pesquisa, campo jornalístico-midiático e campo de atuação na vida pública) — descritos nas seções referentes às práticas de linguagem, destinados aos Anos Finais do Ensino Fundamental. Ademais, interpretamos em que medida as bases teórico-conceituais advindas da Pedagogia dos Multiletramentos estão postas na BNCC de Língua Portuguesa dos Anos Finais do Ensino Fundamental. O aporte teórico se ancora em KALANTZIS, COPE; PINHEIRO (2020); RIBEIRO (2020); CAZDEN ET AL (2021); GRUPO NOVA LONDRES, (2021); entre outros. Quanto à metodologia, recorremos à abordagem qualitativa de base interpretativista, utilizando os procedimentos da pesquisa documental. Os resultados parciais apontam que a BNCC de Língua Portuguesa dos Anos Finais do Ensino Fundamental está revestida de conceitos advindos da Pedagogia dos Multiletramentos, embora esses conceitos não estejam associados diretamente à teoria do GNL (Grupo Nova Londres).
Pharmacological blockade of cannabinoid type II receptors and mesenchymal stem cell transplantation in a model of peripheral neuropathic pain
Authors: Yerofeyeva A.-M. V. , Pinchuk S. V. , Rjabceva S. N. , Molchanova A. Yu. 
Published: January 2024

Objective. To evaluate the anti-nociceptive and reparative effects of adipose-derived mesenchymal stem cells (ADMSCs) under the pharmacological blockade of cannabinoid CB2 receptors in a model of peripheral neuropathic pain.Material and methods. In 40 male Wistar rats, modeling of peripheral neuropathy (NP) was performed by excising a sciatic nerve. On day 7 of the study, ADMSCs (1 × 106 cells/kg) were transplanted into the area of sciatic nerve injury without additional influences or after administration of the CB2 receptor antagonist AM630, as well as after incubation with AM630. Within 90 days, nociceptive sensitivity was studied, as well as a detailed analysis of gait using CatWalk XT (Noldus, Netherlands). On day 21 and day 90, histostructure of the distal segment of the sciatic nerve was assessed.Results. Pharmacological blockade of CB2 receptors both on the ADMSCs and in the soft tissues surrounding the site of sciatic nerve injury led to a decrease in withdrawal threshold and withdrawal latency from day 28 of the study compared with the group of rats with NP and transplantation of ADMSCs only. Local injection of AM630 before transplantation of ADMSCs contributed to the development of NP-induced gait disturbances and increase of the number of damaged nerve fibers in the distal segment of sciatic nerve. Transplantation of ADMSCs pretreated with AM630 did not significantly affect the rate of recovery of gait parameters, and decreased the number of damaged nerve fibers by day 90 of study.Conclusion. Blockade of CB2 receptors, both on the membranes of MSCs and in the area of damage to the peripheral nerve, has a negative effect on the development of the anti-nociceptive and reparative effects of MSCs.
Prevalence of sleep disorders in teenage girls in Irkutsk (questionnaire data)
Authors: Bolshakova S. E. , Madaeva I. M. , Berdina O. N. , Khramova E. E. , Bugun O. V. , Rychkova L. V. 
Published: January 2024

Background. Adequate sleep ensures a person’s physical and psycho-emotional well-being. Adolescence is one of the critical stages of life. The exclusive attention of specialists and leveling the impact of adverse factors on the body during this period is the key to the proper development and preservation of the health of adolescents. Meanwhile, sleep problems in teenage girls remain poorly understood.The aim. To study the features of the sleep regime and quality of sleep of teenage girls in the city of Irkutsk.Materials and methods. A survey of 422 teenage girls in the city of Irkutsk was conducted using a translated version of a questionnaire about adolescent sleep habits to subjectively assess their sleep and wakefulness. Two groups were formed: group I – girls with sleep problems (n = 171); group II – girls without sleep problems (n = 251).Results. Sleep disorders among teenage girls in the city of Irkutsk occurred with a frequency of 40.52 %. In most cases, a complex effect of various unfavorable factors on the sleep process has been identified. The adolescents with sleep disorders we examined were characterized by higher rates of sleep latency, later bedtime, earlier awakening, decreased time of night sleep, as well as changes in the sleep shift indicator towards its increase. These violations were noted both on weekdays and on weekends.Conclusions. Sleep problems were reported in 40.52% of respondents. The complex impact of various unfavorable factors on sleep quality has been revealed. The features of sleep hygiene of teenage girls are reflected. The group of girls with sleep problems was characterized by increased sleep latency, later bedtime, earlier awakening, reduced sleep time, and an increase in sleep shift.
Changes in the pattern of sleep disturbances in healthy subjects under 21-day antiorthostatic hypokinesia
Authors: Kovrov G. V. , Vlasova A. V. , Popova O. V. , Chernikova A. G. 
Published: January 2024

Background. Antiorthostatic hypokinesia (ANOH) reproduces some of the effects of weightlessness on the human body and is used to study adaptation to space flight conditions. It is known that ANOH affects nighttime sleep, but there is no information in the literature on the sequence of occurrence of sleep disorders in ANOH.The aim of the research was to study the dynamics of subjective changes in assessing sleep quality under conditions of antiorthostatic hypokinesia.Materials and methods. Six healthy male volunteers (age from 26 to 34 years) participated in the experiment with 21-day ANOH. They were on a medical bed with a body inclination angle relative to the horizon of –6° for 21 days. To assess sleep quality, a structured questionnaire was used that assessed sleep duration, rate of falling asleep, night awakenings, the presence of daytime sleepiness, and daytime falling asleep.Results. Based on the assessment of the dynamics of the sleep efficiency index (SEI), three stages of adaptation were identified. At the stage of acute adaptation (the first 3 days), there is a decrease in SEI from 96.4 to 91.3 (p < 0.01), a statistically significant prolongation of falling asleep from 17.6 to 33.6 minutes (p < 0.01), an increase duration of night awakenings up to 17.4 minutes, increase in daytime sleepiness by 11 %. In the next 3 days (the “recovery” stage), there is a statistically significant increase in SEI compared to the 1st stage to 94.7 (p < 0.01), but it remains statistically significantly lower than the background values (p < 0.004). The number of complaints about daytime sleepiness increases (up to 42 %), evening bedtime shifts later by 26 minutes. At the 3rd stage (the remaining nights) there is a relative stabilization of the sleep-wake cycle.Conclusion. Under conditions of 21-day ANOH, a gradual change in the pattern of sleep disturbances occurs. The most negative changes in terms of subjective assessment were noted in the first three days. Then there is an improvement in falling asleep, a decrease in night awakenings, combined with an increase in daytime sleepiness and the formation of a schedule with a later bedtime.
Identification and analysis of CRISPR/Cas systems structures in the genomes of antibiotic-resistant strains of <i>Klebsiella pneumoniae</i>
Authors: Stepanenko L. A. , Sukhov B. G. , Kon’kova T. V. , Bedinskaya V. V. , Klushina N. V. , Zlobin V. I. 
Published: January 2024

Background. Klebsiella pneumoniae belongs to a group of opportunistic bacteria that can form multiple resistance to antibiotics and transmit it to various types of bacteria through horizontal gene transfer. These studies examine the structural and functional diversity of CRISPR/Cas systems that protect bacteria from foreign DNA. Their analysis using the example of antibiotic-resistant strains of Klebsiella pneumoniae will demonstrate their resistance to certain bacteriophages, which will make it possible to develop approaches to the treatment of complex infectious diseases caused by these microorganisms by creating targeted phage therapy.The aim. To perform a bioinformatics analysis of the identified structural components of CRISPR/Cas systems for screening bacteriophages through CRISPR cassette spacers using the example of antibiotic-resistant strains of Klebsiella pneumoniae.Materials and methods. The article analyzed 29 full-genome sequences of Klebsiella pneumoniae, in the genome of which the structures of CRISPR/Cas systems and antibiotic resistance genes were determined (according to NCBI). To achieve this goal, using software modeling methods, a search was made for Cas genes and CRISPR cassettes, and their structural and functional characteristics were given.Results. Using bioinformatic search algorithms in the genome of antibiotic-resistant strains, functionally active CRISPR/Cas systems with the presence of one or two CRISPR cassettes and belonging to Type I Subtype IE were identified. Groups of resistant strains with identical spacer composition of CRISPR cassettes have been identified. A phylogenetic analysis was carried out confirming their common origin. By analyzing the spacer sequences of CRISPR cassettes, the spectrum of diversity of phages of bacteria of the genus Klebsiella, Salmonella, belonging to the same family Enterobacteriaceae, was determined. Thus, information was obtained about the bacteriophages that are targeted by the action of CRISPR systems of Klebsiella pneumoniae strains that have antibiotic resistance.Conclusions. Analysis of the functional and structural features of the CRISPR/Cas systems of antibiotic resistant Klebsiella pneumoniae strains made it possible to obtain information about their evolutionary history and about the bacteriophages against which their action is directed, that is, about their phage resistance. The approach used in this study may further serve as the basis for the creation of personalized phage therapy
Hubungan Efikasi Diri dan Tingkat Atensi Dengan Activity Daily Living (ADL) Pasien Pasca Stroke
Authors: Dewi Ni Luh Putu Thrisna , Mirayanti Ni Ketut Ayu , Lisnawati Ketut , Merlin Ni Made 
Published: January 2024

Sudden changes in a person's life after a stroke can cause various negative things in the sufferer, ranging from psychological and behavioral symptoms, including anxiety, feelings of helplessness, mood disorders, low self-efficacy, and impaired attention levels. Psychological problems cause a serious reduction in mobility, because they hinder performance and daily activities or fulfillment of ADLs. This can cause stroke patients to experience job loss and the inability to carry out their social activities. The purpose of this study is the relationship between the self-efficacy of stroke patients and the level of attention to the activity of daily living of post-stroke patients. This study used a correlational analytic method with a Cross-Sectional approach. This research was conducted in one of the private hospitals in Bali, which was held from October 01 - December 30, 2022. With a sample size of 80 respondents of post-stroke patients who control at X Hospital Poly using the Non-probability sampling technique, purposive sampling. The results of this study were that most stroke respondents who experienced low efficacy had a total level of dependence on activity and daily living, as well as stroke who had less attention had a total level of dependence. The results of the correlation test between the two obtained a p-value <0.005 which means there is a significant relationship between efficacy and the level of ADL dependence. This can be an illustration that the psychological condition of post-stroke patients will greatly affect their physical condition. The basis of stroke treatment is of course not only optimizing physical recovery but must also be accompanied by paying attention to the psychological aspects in order to get maximum rehabilitation results.