bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective field theory bootstrap, large-N χPT and holographic QCD
Authors: Li Yue-Zhou 
Published: January 2024

Abstract
We review the effective field theory (EFT) bootstrap by formulating it as an infinite-dimensional semidefinite program (SDP), built from the crossing symmetric sum rules and the S-matrix primal ansatz. We apply the program to study the large-N chiral perturbation theory (χPT) and observe excellent convergence of EFT bounds between the dual (rule-out) and primal (rule-in) methods. This convergence aligns with the predictions of duality theory in SDP, enabling us to analyze the bound states and resonances in the ultra-violet (UV) spectrum. Furthermore, we incorporate the upper bound of unitarity to uniformly constrain the EFT space from the UV scale M using the primal method, thereby confirming the consistency of the large-N expansion. In the end, we translate the large-N χPT bounds to constrain the higher derivative corrections of holographic QCD models.
Newly emerged bumblebees are highly susceptible to gut parasite infection
Authors: Wolmuth-Gordon Hannah S , Nakabayashi Kazumi , Brown Mark JF 
Published: January 2024

AbstractOne factor that can affect infection susceptibility is host age, the effects of which vary in a range of ways. For example, susceptibility may increase with age, due to senescence or decrease with age as a result of maturation of the immune system. If certain ages are more susceptible to infection, populations with contrasting demographics, such as same-age cohorts versus a mixture of ages, will exhibit differing disease prevalence. We use the bumblebee, Bombus terrestris, and its interaction with the gut trypanosome Crithidia sp. as a model system to investigate age-related susceptibility in a social insect. Crithidia sp. are widespread and prevalent parasites of bumblebees that are spread between colonies via faeces on flowers when foraging, and within colonies via contact with infected bees and contaminated surfaces and resources. In the field, Bombus spp. live for approximately three weeks. Here, we inoculated bumblebees at 0, 7, 14 and 21 days of age and measured their infection after one week. We also measured the level of gene expression of two antimicrobial peptides important in the defence against Crithidia bombi in bumblebees. We found that younger bumblebees are more susceptible to infection by Crithidia sp. than their older siblings. Specifically, individuals inoculated on their first day of emergence had infection intensities seven days later that were four-fold higher than bees inoculated at 21 days of age. In contrast, the gene expression of two AMPs known to protect against the trypanosome, abaecin and defensin, did not significantly vary with age. These results suggest that age does affect susceptibility to Crithidia sp. infection in B. terrestris. The higher susceptibility of callows may have implications for the susceptibility of colonies at different stages of their lifecycle, due to the contrasting age demography of workers in the colony.
Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model
Authors: Green Hayley M. , Yang Liang , Zhu Xiao , Finlay David B. , Duffull Stephen B. , Glass Michelle 
Published: January 2024

AbstractAllosteric modulation of CB1 is therapeutically advantageous compared to orthosteric activation as it potentially offers reduced on-target adverse effects. ORG27569 is an allosteric modulator that increases orthosteric agonist binding to CB1 but decreases functional signalling. ORG27569 is characterised by a delay in disinhibition of agonist-induced cAMP inhibition (lag); however, the mechanism behind this kinetic lag is yet to be identified. We aimed to utilise a mathematical model to predict data and design in vitro experiments to elucidate mechanisms behind the unique signalling profile of ORG27569. The established kinetic ternary complex model includes the existence of a transitional state of CB1 bound to ORG27569 and CP55940 and was used to simulate kinetic cAMP data using NONMEM 7.4 and Matlab R2020b. These data were compared with empirical cAMP BRET data in HEK293 cells stably expressing hCB1. The pharmacometric model suggested that the kinetic lag in cAMP disinhibition by ORG27569 is caused by signal amplification in the cAMP assay and can be reduced by decreasing receptor number. This was confirmed experimentally, as reducing receptor number through agonist-induced internalisation resulted in a decreased kinetic lag by ORG27569. ORG27569 was found to have a similar interaction with CP55940 and the high efficacy agonist WIN55,212-2, and was suggested to have lower affinity for CB1 bound by the partial agonist THC compared to CP55940. Allosteric modulators have unique signalling profiles that are often difficult to interrogate exclusively in vitro. We have used a combined mathematical and in vitro approach to prove that ORG27569 causes a delay in disinhibition of agonist-induced cAMP inhibition due to large receptor reserve in this pathway. We also used the pharmacometric model to investigate the common phenomenon of probe dependence, to propose that ORG27569 binds with higher affinity to CB1 bound by high efficacy orthosteric agonists.
Disease Manifestations and Complications in Dutch X-Linked Hypophosphatemia Patients
Authors: Bosman A. , Appelman-Dijkstra N. M. , Boot A. M. , de Borst M. H. , van de Ven A. C. , de Jongh R. T. , Bökenkamp A. , van den Bergh J. P. , van der Eerden B. C. J. , Zillikens M. C. 
Published: January 2024

AbstractX-linked hypophosphatemia (XLH) is the most common monogenetic cause of chronic hypophosphatemia, characterized by rickets and osteomalacia. Disease manifestations and treatment of XLH patients in the Netherlands are currently unknown. Characteristics of XLH patients participating in the Dutch observational registry for genetic hypophosphatemia and acquired renal phosphate wasting were analyzed. Eighty XLH patients, including 29 children, were included. Genetic testing, performed in 78.8% of patients, showed a PHEX mutation in 96.8%. Median (range) Z-score for height was − 2.5 (− 5.5; 1.0) in adults and − 1.4 (− 3.7; 1.0) in children. Many patients were overweight or obese: 64.3% of adults and 37.0% of children. All children received XLH-related medication e.g., active vitamin D, phosphate supplementation or burosumab, while 8 adults used no medication. Lower age at start of XLH-related treatment was associated with higher height at inclusion. Hearing loss was reported in 6.9% of children and 31.4% of adults. Knee deformities were observed in 75.0% of all patients and osteoarthritis in 51.0% of adult patients. Nephrocalcinosis was observed in 62.1% of children and 33.3% of adults. Earlier start of XLH-related treatment was associated with higher risk of nephrocalcinosis and detection at younger age. Hyperparathyroidism longer than six months was reported in 37.9% of children and 35.3% of adults. This nationwide study confirms the high prevalence of adiposity, hearing loss, bone deformities, osteoarthritis, nephrocalcinosis and hyperparathyroidism in Dutch XLH patients. Early start of XLH-related treatment appears to be beneficial for longitudinal growth but may increase development of nephrocalcinosis.
Phosphate-Solubilizing Bacillus sp. Modulate Soil Exoenzyme Activities and Improve Wheat Growth
Authors: Iqbal Zafar , Ahmad Maqshoof , Raza Muhammad Ali , Hilger Thomas , Rasche Frank 
Published: January 2024

AbstractPhosphorus (P) is a vital mineral nutrient in agriculture and its deficiency results in reduced growth, yield, and grain quality in cereals. Much of the applied P in agriculture becomes fixed in soils, limiting its accessibility to plants. Thus, investigating sustainable strategies to release fixed P resources and enhance plant uptake is crucial. This study explored how plant-associated bacteria employ phosphate solubilizing mechanisms to improve P availability. The growth patterns of four bacterial strains, namely Bacillus subtilis ZE15 and ZR3, along with Bacillus megaterium ZE32 and ZR19, were examined in Pikovskaya’s broth culture with and without the addition of insoluble phosphorus (P). In the absence of P amendment, most strains reached a stationary growth phase by the fourth day. However, their responses diverged when exposed to P-amended media. Particularly, ZE15 demonstrated the highest P solubilization capability, achieving up to 130 µg mL−1 solubilization in vitro. All strains produced organic acids in Pikovskaya’s broth culture. A comparison of the influence of Ca3(PO4)2 revealed significantly greater organic acid quantities in the presence of insoluble P. Notably, strain ZE15 exhibited the highest phosphate esterase activity (3.65 nmol g−1 dry matter), while strain ZE32 showed the highest ß-D glucosidase activity (2.81 nmol g−1 dry matter) in the presence of insoluble P. The ability of Bacillus species to solubilize P in combination with increased exoenzyme activity in the rhizosphere could be used in future studies to support P uptake through enhanced solubilization and mineralization.
Dieback and Replacement of Riparian Trees May Impact Stream Ecosystem Functioning
Authors: Alonso Alberto , Boyero Luz , Solla Alejandro , Ferreira Verónica 
Published: January 2024

AbstractAlders are nitrogen (N)-fixing riparian trees that promote leaf litter decomposition in streams through their high-nutrient leaf litter inputs. While alders are widespread across Europe, their populations are at risk due to infection by the oomycete Phytophthora ×alni, which causes alder dieback. Moreover, alder death opens a space for the establishment of an aggressive N-fixing invasive species, the black locust (Robinia pseudoacacia). Shifts from riparian vegetation containing healthy to infected alder and, eventually, alder loss and replacement with black locust may alter the key process of leaf litter decomposition and associated microbial decomposer assemblages. We examined this question in a microcosm experiment comparing three types of leaf litter mixtures: one representing an original riparian forest composed of healthy alder (Alnus lusitanica), ash (Fraxinus angustifolia), and poplar (Populus nigra); one with the same species composition where alder had been infected by P. ×alni; and one where alder had been replaced with black locust. The experiment lasted six weeks, and every two weeks, microbially driven decomposition, fungal biomass, reproduction, and assemblage structure were measured. Decomposition was highest in mixtures with infected alder and lowest in mixtures with black locust, reflecting differences in leaf nutrient concentrations. Mixtures with alder showed distinct fungal assemblages and higher sporulation rates than mixtures with black locust. Our results indicate that alder loss and its replacement with black locust may alter key stream ecosystem processes and assemblages, with important changes already occurring during alder infection. This highlights the importance of maintaining heathy riparian forests to preserve proper stream ecosystem functioning.
3000 leagues under the sea: the voyages of vagrant walruses (Odobenus rosmarus) in temperate Europe
Authors: Chiacchio Michele , Aae Rune 
Published: January 2024

AbstractSightings of vagrant walruses in Europe have been known since historic times, yet whether this phenomenon remains constant or changes over time is unclear. In this study, we conducted a comprehensive cross-reference of information on vagrant walruses observed in temperate Europe (below 61° N) between 1923 and 2022 utilising data from the Global Biodiversity Information Facility depository. In addition, we conducted an online search of records from the last ten years, resulting in a detailed reconstruction of the movements of the most recently observed individuals. We estimated that between 31 and 36 different individuals have been observed over the last century, with most of these likely originating from the Svalbard region and only a few from Greenland. A comparison in the yearly number of records showed a significant increase over time, suggesting that vagrant walruses reach Europe as a result of a combination of climatic and meteorological events as well as of demographic changes in the populations of the North Atlantic.
Truthful cake sharing
Authors: Bei Xiaohui , Lu Xinhang , Suksompong Warut 
Published: January 2024

Abstract
The classic cake cutting problem concerns the fair allocation of a heterogeneous resource among interested agents. In this paper, we study a public goods variant of the problem, where instead of competing with one another for the cake, the agents all share the same subset of the cake which must be chosen subject to a length constraint. We focus on the design of truthful and fair mechanisms in the presence of strategic agents who have piecewise uniform (i.e., approval) utilities over the cake. On the one hand, we show that the leximin solution is excludably truthful (meaning it is truthful when it can block each agent from accessing parts of the cake that the agent does not claim to desire) and moreover maximizes the guaranteed normalized egalitarian welfare among all excludably truthful and position oblivious mechanisms. On the other hand, we demonstrate that the maximum Nash welfare solution is excludably truthful for two agents (as it coincides with leximin in that case) but not in general. We also provide an impossibility result on truthfulness when blocking is not allowed, and adapt notions of representation to our setting.
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Authors: Chen Weixin , Ran Siyi , Li Chenchang , Li Zhixin , Wei Nili , Li Jing , Li Naijian 
Published: January 2024

Abstract
Background
Non-cystic fibrosis bronchiectasis is a chronic respiratory disease characterized by bronchial dilation. However, the significance of elevated eosinophil counts in acute exacerbations of bronchiectasis remains unclear.

Methods
This retrospective case-control study included 169 hospitalized patients with acute exacerbations of non-cystic fibrosis bronchiectasis. Based on blood eosinophil levels, patients were categorized into eosinophilic and non-eosinophilic bronchiectasis groups. Various clinical variables, including lung function, comorbidities and clinical features were collected for analysis. The study aimed to examine the differences between these groups and their clinical phenotypes.

Results
Eosinophilic bronchiectasis (EB) was present in approximately 22% of all hospitalized patients with bronchiectasis, and it was more prevalent among male smokers (P < 0.01). EB exhibited greater severity of bronchiectasis, including worse airway obstruction, higher scores in the E-FACED (FACED combined with exacerbations) and bronchiectasis severity index (BSI), a high glucocorticoids medication possession ratio, and increased hospitalization cost (P < 0.05 or P < 0.01). Furthermore, we observed a significant positive correlation between blood eosinophil count and both sputum eosinophils (r = 0.49, P < 0.01) and serum total immunoglobulin E levels (r = 0.21, P < 0.05). Additional analysis revealed that patients with EB had a higher frequency of shortness of breath (P < 0.05), were more likely to have comorbid sinusitis (P < 0.01), and exhibited a greater number of lung segments affected by bronchiectasis (P < 0.01).

Conclusions
These findings suggest that EB presents a distinct pattern of bronchiectasis features, confirming the notion that it is a specific phenotype.
Why identification matters: an explorative study on six cases of family reunification
Authors: Franceschetti Lorenzo , Mazzarelli Debora , Ragni Chiara , Paltenghi Francesca , Pecoraro Andrea , Albani Denise , Giuffrida Roberto , Siccardi Cecilia , Polizzi Nicolò , Di Simone Paola , D’Apuzzo Annalisa , Mandrioli Daniele , Buscemi Martina , D’Amico Marilisa , Viarengo Ilaria , Cattaneo Cristina 
Published: January 2024

AbstractThe escalating phenomenon of migration, accompanied by a disturbing surge in associated tragedies, has persistently violated internationally protected human rights. Absence of physical evidence, namely the presence of adequately identified corpses, may impede the full enjoyment of human rights and—in some cases—the course of justice as it obstructs the initiation of legal proceedings against individuals implicated in causing such catastrophes. It also presents administrative obstacles, as death certificates are indispensable in legitimizing statuses like orphanhood and widowhood. Family reunification, particularly for orphans, plays a significant role for those attempting to reconnect with their relatives all over the world. Likewise, for mothers, the acknowledgment of their marital status or widowhood can be a pathway to regain their marginalized right to social life. To elucidate this issue, we analyzed six representative cases from the tragic October 3, 2013, shipwreck near the Italian island of Lampedusa, where 366 individuals were retrieved dead from the sea. These cases underscore the practical challenges involved, highlighting the compelling need for continued efforts to ensure that this burdensome problem transcends from being a mere ethical, moral, and legal discourse. Although considerable progresses, these cases also reveal that substantial work still lies ahead. There is a pressing need for improved mechanisms to certify kinship ties, which are often the limiting factor in many reunifications, and can hinder the granting of custody to children. The severity and far-reaching implications of this problem necessitate thoughtful attention and action, especially considering the ongoing escalation in migration and related fatalities.
Brecciation and fracturing by water ingress into the Genbudo basaltic andesitic lava flow, Iwate volcano, northeastern Japan
Authors: Hoshide Takashi , Ishibashi Nao , Iwahashi Keisuke 
Published: January 2024

AbstractThe Genbudo lava, the late Pleistocene basaltic-andesitic lava flow in the southwestern part of Iwate Volcano, Japan, is a 70 m thick columnar jointed flow that can be divided into three parts from bottom to top: the colonnade, the entablature, and the partly-brecciated uppermost part. Two main types of fractures developed in the entablature: pseudopillow fractures that formed in a branching network-like pattern throughout the entablature, and sheet fractures with curved surfaces that are nearly parallel to each other. At the uppermost part of the flow, finger-like structures of lava extend upward from the coherent lava, and cogenetic autoclastic rocks form between the fingers. This occurrence suggests that hyaloclastites were generated during emplacement in the uppermost part of the flow, apparently when water from a dammed river valley covered the flow. The texture of the lava near the pseudopillow fractures in the entablature is commonly hypocrystalline, while the texture in other parts is holocrystalline. There are two types of pyroxene microlites, large prismatic (average size ~ 30 µm) and dendritic (< 10 µm in length) crystals in the lava near the pseudopillow fractures. These suggest that the cooling rate of the lava was greatest in the vicinity of the pseudopillow fractures. Networks of palagonite-filled micro-fractures (less than 10 µm in width) are found in this part of the flow, and many bubbles are observed along the fractures. This is clear evidence that the rapid cooling of the lava was caused by water infiltration through the pseudopillow fractures. From the measurement of Fe-rich droplet sizes that formed due to liquid immiscibility within the lava, we estimate the cooling rate within the colonnade as about 49 °C/h and within the entablature as 642 °C/h, consistent with much more rapid cooling by water infiltration from above.
Neural network classification of eigenmodes in the magnetohydrodynamic spectroscopy code Legolas
Authors: De Jonghe J. , Kuczyński M. D. 
Published: January 2024

AbstractA neural network is employed to address a non-binary classification problem of plasma instabilities in astrophysical jets, calculated with the code. The trained models exhibit reliable performance in the identification of the two instability types supported by these jets. We also discuss the generation of artificial data and refinement of predictions in general eigenfunction classification problems.
Patients with a large ossification of the posterior longitudinal ligament have a higher incidence of arteriosclerosis in the carotid artery
Authors: Oshima Yasushi , Doi Toru , Ohtomo Nozomu , Ito Yusuke , Nakajima Koji , Nagata Kosei , Kato So , Taniguchi Yuki , Matsubayashi Yoshitaka , Tanaka Sakae 
Published: January 2024

Abstract
Purpose
This study aimed to investigate the impact of the severity of cervical ossification of the posterior longitudinal ligament (OPLL) on the incidence of arteriosclerosis in the carotid artery.

Methods
Patients with OPLL-induced cervical myelopathy were prospectively enrolled. The study involved analyzing patient characteristics, blood samples, computed tomography scans of the spine, and intima-media thickness (IMT) measurements of the common carotid artery. Patients were divided into two groups based on the size of the cervical OPLL to compare demographic data, comorbidities, and the presence of thickening of the carotid intima-media (max IMT ≥ 1.1 mm).

Results
The study included 96 patients (mean age: 63.5 years; mean body mass index: 26.9 kg/m2; 71.8% male; 35.4% with diabetes mellitus). The mean maximum anteroposterior (AP) diameter of the OPLL was 4.9 mm, with a mean occupancy ratio of 43%. The mean maximum IMT was 1.23 mm. Arteriosclerosis of the carotid artery was diagnosed in 62.5% of the patients. On comparing the two groups based on OPLL size, the group with larger OPLL (≥ 5 mm) had a higher BMI and a greater prevalence of carotid intima-media thickening. This significant difference in the prevalence of carotid intima-media thickening persisted even after adjusting for patient backgrounds using propensity score matching.

Conclusions
Patients with a larger cervical OPLL showed a higher frequency of intima-media thickening in the carotid artery.
Microsatellites reveal high levels of genetic admixture in the natural populations of Laurus azorica, Lauraceae
Authors: Rego Rúben M. C. , Vieira Ângela F. , Silva Luís , Elias Rui , Silva Carlos , Resendes Roberto , Moura Mónica 
Published: January 2024

AbstractLaurus (Lauraceae) species are currently restricted to isolated refugia in the southern Black Sea, Mediterranean Basin, southern Morocco, and Macaronesian archipelagos. One to three species of Laurus has been recognized: the Azorean endemic Laurus azorica, L. nobilis from the Mediterranean, and L. novocanariensis from Madeira and the Canary Islands. This study aims to determine the population structure, genetic diversity, and associated patterns of gene flow within and between Azorean populations, using eight existing SSR markers. We also included plant material from L. nobilis populations found in the Azores, for comparison. Amplification was performed in 212 samples of L. azorica and in 30 samples of L. nobilis. For L. azorica, 78 alleles were amplified (average 9.75 alleles per loci). Bayesian analysis with STRUCTURE unveiled five genetic groups for the Azorean accessions, with high level of genetic admixture. Genetic diversity was generally high, with moderate levels of genetic differentiation among L. azorica populations. Moreover, high gene flow levels, likely mediated by past human translocations and naturally, by birds, might have contributed to the high level of genetic admixture observed possibly reflecting hybridization events between L. nobilis and L. azorica. Conservation measures should be applied to some populations of São Miguel, Santa Maria, and Flores Islands, based on the number of private alleles, and further, ad hoc translocation events should be avoided. Conservation in situ and the preservation of laurel forest remains are recommended. The study of this species’ taxonomy, genetics, and population dynamics in the Macaronesian region should be continued.