bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of physical activity in community-dwelling older adults: an umbrella review
Authors: D’Amore Cassandra , Saunders Stephanie , Bhatnagar Neera , Griffith Lauren E. , Richardson Julie , Beauchamp Marla K. 
Published: November 2023

Abstract
Introduction
Physical activity (PA) is critical for disease prevention and maintaining functional ability with aging. Despite this, as many as 50% of older adults in populations worldwide are considered insufficiently active. There is a recognized need to mobilize policies targeted toward modifiable determinants of healthy aging like PA. This umbrella review aimed to summarize the evidence for determinants of PA in community-dwelling older adults.

Methods
A research librarian searched six databases. Systematic and scoping reviews were included if they investigated community-dwelling people with a mean age of 60 + years and examined a relationship between a determinant and any type of PA. Two independent reviewers screened and extracted data from all reviews. JBI methodology and Critical Appraisal Checklist for Systematic Reviews and Research Syntheses were followed and information on the quality of the evidence was extracted.

Results
From 17,277 records screened,11 reviews representing > 300 unique primary papers were ultimately included. Only 6% of studies included in all reviews had longitudinal designs. Included studies used a large variety of PA measures, with 76% using only self-report, 15% using only direct measures (e.g., accelerometry), 3% using both types, and 6% with no outcome measure reported. Only four reviews provided a definition of PA and there was substantial inconsistency in the way PA was categorised. Community level influences, which only included the physical environment, were the most commonly assessed (6/11) with more than 70% of the summarized relationships demonstrating null associations. Three out of four reviews reported a positive relationship between walkability and PA in general community-dwelling older adults. There was also evidence supporting relationships between presence of social support for PA, younger age, and men having higher PA from a single systematic review. None of the included reviews assessed the quality of evidence but over 60% performed a risk of bias assessment.

Conclusions
Walkability, age, gender, and social support for PA were the most supported PA determinants identified. Further research should focus on interpersonal and intrapersonal influences and incorporate direct measures of PA with clear operational definitions. There is a need for longitudinal study designs to further understand determinants of PA behaviour trajectories.
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
Authors: Liang Yusheng , kang Xu , Zhang Haiwang , Xu Heng , Wu Xian 
Published: November 2023

Abstract
Background
Previously we reported that inhibition of GPR17 prevents amyloid β 1–42 (Aβ1-42)-induced cognitive impairment in mice. However, the role of GPR17 on cognition is still largely unknown.

Methods
Herein, we used a mouse model of cognitive impairment induced by lipopolysaccharide (LPS) to further investigate the role of GPR17 in cognition and its potential mechanism. The mice were pretreated with GPR17 shRNA lentivirus and cangrelor by microinjection into the dentate gyrus (DG) region of the hippocampus. After 21 days, LPS (0.25 mg/kg, i.p.) was administered for 7 days. Animal behavioral tests as well as pathological and biochemical assays were performed to evaluate the cognitive function in mice.

Results
LPS exposure resulted in a significant increase in GPR17 expression at both protein and mRNA levels in the hippocampus. Gene reduction and pharmacological blockade of GPR17 improved cognitive impairment in both the Morris water maze and novel object recognition tests. Knockdown and inhibition of GPR17 inhibited Aβ production, decreased the expression of NF-κB p65, increased CREB phosphorylation and elevated BDNF expression, suppressed the accumulation of pro-inflammatory cytokines, inhibited Glial cells (microglia and astrocytes) activation, and increased Bcl-2, PSD-95, and SYN expression, reduced Bax expression as well as decreased caspase-3 activity and TUNEL-positive cells in the hippocampus of LPS-treated mice. Notably, knockdown and inhibition of GPR17 not only provided protective effects against cholinergic dysfunction but also facilitated the regulation of oxidative stress. In addition, cangrelor pretreatment can effectively inhibit the expression of inflammatory cytokines by suppressing NF-κB/CREB/BDNF signaling in BV-2 cells stimulated by LPS. However, activation of hippocampal GPR17 with MDL-29951 induced cognitive impairment in normal mice.

Conclusions
These observations indicate that GPR17 may possess a neuroprotective effect against LPS-induced cognition deficits, and neuroinflammation by modulation of NF-κB/CREB/BDNF signaling in mice, indicating that GPR17 may be a promising new target for the prevention and treatment of AD.
The impact of local supply of popular contraceptives on women’s use of family planning: findings from performance-monitoring-for-action in seven sub-Saharan African countries
Authors: Kristiansen Devon , Boyle Elizabeth Heger , Svec Joseph 
Published: November 2023

AbstractContraceptive use has substantial implications for women’s reproductive health, motivating research on the most effective approaches to minimize inequalities in access. When women prefer to limit or delay fertility but are not using contraception, this potentially reflects demand for contraception that is not being satisfied. Current literature emphasizes a nuanced integration of supply and demand factors to better understand this gap. In this research, we examine the interconnectedness of supply and demand factors both conceptually and methodologically by augmenting existing measures of local supply with a demand-side factor—community-level preferences for contraceptive methods. Using novel data from Performance Monitoring for Action (PMA) in seven sub-Saharan African countries, we test whether the available supply of locally preferred methods at nearby service delivery points (SDP) explains variation in women’s uptake of contraception beyond the more typical measure of contraceptive stockouts. Findings from logistic regression analyses (N = 32,282) suggest that demand and supply can be understood as tightly interconnected factors which are directly affected by local social preferences. The odds of women using modern contraception increase significantly when locally preferred methods are available, and this is true even after controlling for the availability of methods in general. The new measure tested in this research centers women and their specific desires in a manner consistent with the promotion of contraceptives as an important human right.
Efficacy and safety of platelet-rich plasma combined with Tai Chi for knee osteoarthritis: study protocol for a placebo-controlled randomized trial
Authors: Yang Kun , Ding Yuwu , Xu Haichen , Lai Minghui , Xu Xueping , Yu Xiaoming , Deng Qian , Jiang Liming 
Published: November 2023

Abstract
Background
No definitive treatment methods of curative for knee osteoarthritis (KOA). The combined therapies that into account both the biochemical and biomechanical may provide potential opportunities for treat KOA, and previous studies have demonstrated that the platelet-rich plasma of intra-articular injection (IAI-PRP) and exercise treatments afford more benefits than do their corresponding monotherapies. The absence of a specific exercise plan and detailed explanation renders the aforementioned study results questionable. Furthermore, Tai Chi (TC) with moderate-intensity, whole body movements and good adherence may prove to be more effective for treating KOA. However, few studies examined the effectiveness and safety of combined IAI-PRP and TC for KOA.

Methods
This study protocol will be a placebo-controlled, assessor-blinded randomized trial involving 12-week intervention and 1-year follow-up. The stratified randomization will be used to randomly assign the 212 participants to four groups: group A (placebo IAI); group B (PRP IAI); group C (TC and placebo IAI); group D (TC and PRP IAI). Injection will be performed once a week, three consecutive times as a course, after a week of rest to continue the next course, a total of 3 courses (12 week). Additionally, the TC interventions will be carried out 3 days per week for a total of 12 weeks. The primary outcome measures will include the efficacy (Western Ontario and McMaster Universities Osteoarthritis Index), acceptability and safety of these interventions. The secondary outcome measures will include physical function (Timed Up and Go test), walking function (Gait Analysis), inflammatory factor levels (e.g., Interleukin-1 β, interleukin-6, vascular endothelial growth factor), quality of life (36-Item Short Form Health Survey), volume of patellofemoral cartilage and effusion-synovitis (MRI). Two-way of variance with repeated measures will be applied to examine the main effects of the group and the time factor and group-time interaction effects for all outcome measures.

Discussion
This trial will be first one to propose an integrated scheme combing IAI-PRP and TC for treatment of KOA, based on the consideration of the biochemical and biomechanical pathogenesis of KOA. These results of the study will provide evidence with high quality for integrated IAI-PRP and TC to treatment KOA.
Trial Registration Chinese Clinical Trial Registry ChiCTR2300067559. Registered on 11 January 2023.
Remnant cholesterol and severity of nonalcoholic fatty liver disease
Authors: Huang Hangkai , Wang Jinghua , Wu Li , Ruan Jiaqi , Hou Linxiao , Shen Chao , Xu Chengfu 
Published: November 2023

Abstract
Background
Serum remnant cholesterol levels are being increasingly acknowledged as a causal risk factor for atherosclerotic disease, regardless of conventional lipid parameters. The positive association between remnant cholesterol and nonalcoholic fatty liver disease (NAFLD) has been revealed in previous studies. However, whether remnant cholesterol is associated with the severity of NAFLD remains unknown. This study aimed to explore the association between serum remnant cholesterol and the risk of NAFLD severity.

Methods
This cross-sectional study included a total of 6,053 participants who attended health checkups. The severity of hepatic steatosis was evaluated by liver ultrasound transient elastography. Univariable and multivariable logistic regression analyses were performed to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for the association between remnant cholesterol and the severity of hepatic steatosis. To explore whether the association between remnant cholesterol and NAFLD severity was independent of conventional lipid parameters, we further investigated this association in individuals with normal values of low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides.

Results
In total, 36.9% of individuals had mild steatosis, and 5.9% had moderate-to-severe steatosis. The serum level of remnant cholesterol in nonsteatosis, mild steatosis and moderate-to-severe steatosis gradually increased (0.71 ± 0.33, 0.97 ± 0.52 and 1.07 ± 0.63 mmol/L, respectively). In the multivariable mode, remnant cholesterol was positively associated with mild hepatic steatosis (OR: 1.730, 95% CI: 1.541 − 1.941, P < 0.001) and moderate-to-severe steatosis (OR: 2.342, 95% CI: 1.765 − 3.109, P < 0.001). These associations were not significantly altered in individuals with normal triglycerides, HDL-C and LDL-C (OR: 1.664, 95% CI: 1.448 − 1.911, P < 0.001; OR: 2.269, 95% CI: 1.619 − 3.180, P < 0.001, respectively).

Conclusions
Higher levels of serum remnant cholesterol were associated with more severe hepatic steatosis, regardless of conventional lipid parameters. Individuals with higher remnant cholesterol may need more attention in regular surveillance of NAFLD.
Proceedings of the inaugural Dark Genome Symposium: November 2022
Authors: Boeke Jef D. , Burns Kathleen H. , Chiappinelli Katherine B. , Classon Marie , Coffin John M. , DeCarvalho Daniel D. , Dukes Joseph D. , Greenbaum Benjamin , Kassiotis George , Knutson Sarah K. , Levine Arnold J. , Nath Avindra , Papa Sophie , Rios Daniel , Sedivy John , Ting David T. 
Published: November 2023

AbstractIn November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape into therapies for human disease. The spirit and ambition of the meeting was one of shared knowledge, looking to strengthen the network of researchers engaged in the field. The meeting opened with a welcome from Rosana Kapeller and Kevin Pojasek followed by a first session of field defining talks from key academics in the space. A series of panels, bringing together academia and industry views, were then convened covering a wide range of pertinent topics. Finally, Richard Young and David Ting gave their views on the future direction and promise for patient impact inherent in the growing understanding of the Dark Genome.
Proximal linearized method for sparse equity portfolio optimization with minimum transaction cost
Authors: Sim Hong Seng , Ling Wendy Shin Yie , Leong Wah June , Chen Chuei Yee 
Published: November 2023

AbstractIn this paper, we propose a sparse equity portfolio optimization model that aims at minimizing transaction cost by avoiding small investments while promoting diversification to help mitigate the volatility in the portfolio. The former is achieved by including the $\ell _{0}$

ℓ
0

-norm regularization of the asset weights to promote sparsity. Subjected to a minimum expected return, the proposed model turns out to be an objective function consisting of discontinuous and nonconvex terms. The complexity of the model calls for proximal method, which allows us to handle the objective terms separately via the corresponding proximal operators. We develop an efficient algorithm to find the optimal portfolio and prove its global convergence. The efficiency of the algorithm is demonstrated using real stock data and the model is promising in portfolio selection in terms of generating higher expected return while maintaining good level of sparsity, and thus minimizing transaction cost.
Phase patterning of metallic glasses through superfast quenching of ion irradiation-induced thermal spikes
Authors: Kim Hyosim , Wang Tianyao , Gigax Jonathan , Zare Arezoo , Lucca Don A. , Hu Zhihan , Li Yongchang , Parker Trevor , Shao Lin 
Published: November 2023

AbstractAmorphous metallic glasses (MGs) convert to crystalline solids upon annealing at a high temperature. Such a phase change, however, does not occur with the local melting caused by damage cascades introduced by ion irradiation, although the resulting thermal spikes can reach temperatures > 1000 K. This is because the quenching rate of the local melting zone is several orders of magnitude higher than the critical cooling rate for MG formation. Thus the amorphous structure is sustained. This mechanism increases the highest temperature at which irradiated MG sustains amorphous phase. More interestingly, if an irradiated MG is pre-annealed to form a polycrystalline structure, ion irradiation can locally convert this crystalline phase to an amorphous phase if the grains are nanometers in size and comparable to the damage cascade volume size. Combining pre-annealing and site selective ion irradiation, patterned crystalline-amorphous heterogeneous structures have been fabricated. This finding opens new doors for various applications.
Improvements in the determination of attogram-sized 231Pa in dissolved and particulate fractions of seawater via multi-collector inductively coupled plasma mass spectrometry
Authors: Zhang Pu , Lu Yanbin , Zhang Zhe , Edwards Richard Lawrence , Anderson Robert , Lam Phoebe 
Published: November 2023

AbstractA technique is developed to quantify the ultra-trace 231Pa (35–3904 ag) concentration in seawater using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). The method is a modification of the process developed by Shen et al. (Anal Chem 75(5):1075–1079, 2003. https://doi.org/10.1021/ac026247r) and extends it to the application of very low levels of actinides, and the 35 ag 231Pa can be measured with a precision of 15%. The total process blank for the water column was 0.02 ag/g, while the values of the large and small particles were ~ 30 ag/g. The ionization efficiency (ions generated/atom loaded) varies from 0.7 to 2.4%. The measurement time is 2–5 min. The amount of 231Pa needed to produce 231Pa data with an uncertainty of ± 0.8–15% is 35–3904 ag (~ 0.9 × 105 to 10 × 106 atoms). Replicate measurements of known standards and seawater samples demonstrate that the analytical precision approximates that expected from counting statistics, and that based on detection limits of 52 ag, 55 ag, and 28 ag, protactinium can be detected in a minimum seawater sample size of ~ 2.6 L for small suspended particulate matter (> 0.8 μm and < 51 μm), ~ 3.0 L for large suspended particulate matter (> 51 μm), and ~ 56 mL for filtered (< 0.45 μm) seawater. The concentration of 231Pa (several attograms per liter) can be determined with an uncertainty of ± 2–8% (2σ) for suspended particulate matter filtered from ~ 60 L of seawater. For the dissolved fraction, ~ 1 L of seawater yields 231Pa measurements with a precision of 0.8–10%. The sample size requirements are several orders of magnitude less than traditional decay-counting techniques, and the precision is better than that previously reported for ICP-MS techniques. Our technique can also be applied to other environmental samples, including river, lake, and cave water samples.
Parametric and non-parametric Poisson regression for modelling of the arterial input function in positron emission tomography
Authors: Matheson Granville J. , Ge Liner , Zhang Mengyu , Sun Bingyu , Tu Yuqi , Zanderigo Francesca , Forsberg Morèn Anton , Ogden R. Todd 
Published: November 2023

AbstractFull quantification of Positron Emission Tomography (PET) requires an arterial input function (AIF) for measurement of certain targets, or using particular radiotracers, or for the quantification of specific outcome measures. The AIF represents the measurement of radiotracer concentrations in the arterial blood plasma over the course of the PET examination. Measurement of the AIF is prone to error as it is a composite measure created from the combination of multiple measurements of different samples with different equipment, each of which can be sources of measurement error. Moreover, its measurement requires a high degree of temporal granularity for early time points, which necessitates a compromise between quality and quantity of recorded samples. For these reasons, it is often desirable to fit models to this data in order to improve its quality before using it for quantification of radiotracer binding in the tissue. The raw observations of radioactivity in arterial blood and plasma samples are derived from radioactive decay, which is measured as a number of recorded counts. Count data have several specific properties, including the fact that they cannot be negative as well as a particular mean-variance relationship. Poisson regression is the most principled modelling strategy for working with count data, as it both incorporates and exploits these properties. However, no previous studies to our knowledge have taken this approach, despite the advantages of greater efficiency and accuracy which result from using the appropriate distributional assumptions. Here, we implement a Poisson regression modelling approach for the AIF as proof-of-concept of its application. We applied both parametric and non-parametric models for the input function curve. We show that a negative binomial distribution is a more appropriate error distribution for handling overdispersion. Furthermore, we extend this approach to a hierarchical non-parametric model which is shown to be highly resilient to missing data. We thus demonstrate that Poisson regression is both feasible and effective when applied to AIF data, and propose that this is a promising strategy for modelling blood count data for PET in future.
Two cases of colorectal liver metastasis with residual liver recurrence after a long recurrence-free survival period
Authors: Yagi Shotaro , Takahashi Makoto , Tsuji Taiki , Yanagibashi Susumu , Higashihara Taku , Ohtsuka Hideo , Hayashi Tatsuya , Takuma Kunio , Morita Yasuhiro , Nakazono Ayano , Okada Haruka , Ohtsuka Masayuki 
Published: November 2023

Abstract
Background
The rate of residual liver recurrence after the resection of colorectal liver metastases is high, and most cases recur within 5 years of the initial hepatectomy. Here, we report two cases of residual liver recurrence after radical resection of colorectal liver metastases after a long recurrence-free survival period.

Case presentation
Case 1 involved a 62-year-old woman treated for ascending colon cancer in April 2011 who underwent right hepatectomy for synchronous colorectal liver metastasis in April 2012. However, in September 2021, computed tomography revealed residual recurrence in the lateral segment of the liver, and a lateral segmentectomy of the liver was performed. In Case 2, a 52-year-old man treated for cecal cancer in July 2002 underwent lateral segmentectomy of the liver for metachronous colorectal liver metastasis in October 2006. Subsequently, there was no recurrence; however, computed tomography showed residual liver recurrence in the right lobe of the liver in October 2021, and an expanded posterior hepatic segmentectomy was performed.
Histopathological findings in both cases were consistent with colorectal liver metastases.

Conclusions
We encountered two cases in which residual liver recurrence was observed after a long period of recurrence-free survival. Although rare, there have been a few cases of late recurrence of liver metastases after radical resection of cancer liver metastases.
Abdominal compartment syndrome as a complication of endoscopic carbon dioxide insufflation in a patient with malignant bowel obstruction: a case report
Authors: Tanabe Taro , Tsukuda Genki , Hobo Takahiro , Yokoyama Noboru , Inoue Haruhiro 
Published: November 2023

Abstract
Background
A self-expandable metal stent is often placed as a bridge to elective surgical treatment of left-sided malignant obstruction of the colon because it allows for primary anastomosis without the need for a temporary stoma, which has a positive impact on the patient’s quality of life. However, although a relatively safe procedure, colonic stenting can have complications that require emergency surgery. This case report describes a rare case of abdominal compartment syndrome that occurred as a complication of endoscopic insufflation during colonic stenting.

Case presentation
The patient was a 72-year-old woman who presented complaining of several days of constipation and loss of appetite. Computed tomography of the abdomen revealed obstruction of the sigmoid colon by a tumor. There were no symptoms or computed tomography findings to suggest perforation. Therefore, an attempt was made to insert a self-expandable metal stent. Acute respiratory disturbance and a change in consciousness occurred during the stenting procedure, with marked abdominal distention. Abdominal compartment syndrome was diagnosed and treated by decompressive laparotomy.

Conclusions
To the best of our knowledge, this is the first reported case of abdominal compartment syndrome as a complication of endoscopic insufflation during colonic stenting. The possibility of abdominal compartment syndrome should be considered if acute respiratory disturbance or altered consciousness occurs during endoscopic procedure in a patient with malignant bowel obstruction.