bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D‐Printed Ultra‐Thin Non‐Prep Lithium Disilicate Veneers: A Proof‐of‐Concept Clinical Case
Authors: Unkovskiy Alexey , Beuer Florian , Hey Jeremias , Bomze Daniel , Schmidt Franziska 
Published: January 2025

ABSTRACTObjectiveTo test the clinical application of LCM‐printed lithium disilicate veneers.Clinical ConsiderationsA female patient with tooth wear was scanned with intraoral scanner (Prime Scan, Dentsply Sirona). The six non‐prep veneers were designed (DentalCAD, Exocad) and printed from lithium disilicate with an LCM‐printer with the thickness of 0.1–0.2 mm (CeraFab System S65 Medical, Lithoz GmbH). The green parts after printing were cleaned of the excess slurry and debindered in a furnace (Nabertherm, Lilienthal) until 430°C with a dwell time of 5 h to remove all polymeric binder. The resulting parts were sintered in an oven (Programat P510, Ivoclar Vivadent AG) at a temperature of 900°C. The supports were removed with a dental technician handpiece (Perfecta 900, W & H). The final restorations were stained (e‐max Ceram, Ivoclar Vivadent AG) by a master dental technician.ConclusionsThe six LCM‐printed ultra‐thin non‐prep lithium disilicate veneers were tried‐in on the patient using a try‐in glycerin gel (Ivoclar Vivadent, Schaan, Lichtenstein) and demonstrated excellent fit and esthetics. LCM technology enabled the production of ultra‐thin non‐prep lithium disilicate veneers with layer thicknesses of down to 0.1 mm.Clinical SignificanceThe 3D‐printing of ultra‐thin non‐prep veneers is technically feasible and provides an adequate clinical outcome. Additive manufacturing of ultra‐thin non‐prep lithium disilicate veneers may pose a valid alternative to conventional and subtractive manufacturing.
Closed‐loop vibration stimulation based on heart rhythm for reducing sleep inertia
Authors: Son Hyo Won , Kim Sang Hyuk , Lee Tae Mu , Heo Hyoyoung , Kwon Hyun Bin , Choi Byunghun , Yoon Heenam , Baek Hyun Jae 
Published: January 2025

SummaryThe aim of this study was to determine whether closed‐loop vibration stimulation, delivered at +3% of the heart rate frequency at an imperceptible intensity before waking, could reduce sleep inertia. Participants napped on a bed equipped with a woofer that delivered vibration stimulation every 5 min, starting 30 min before their scheduled wake time. The effects of the stimulation were assessed using a Psychomotor Vigilance Task performed immediately upon waking, along with the analysis of salivary cortisol and melatonin levels, as well as subjective arousal ratings based on the Karolinska Sleepiness Scale and the Stanford Sleepiness Scale. The results indicated that vibration stimulation at +3% of the heart rate frequency improved Psychomotor Vigilance Task reaction times and increased self‐reported arousal scores, thus reducing sleep inertia compared with the control condition without stimulation. Additionally, salivary melatonin levels were lower immediately after waking. These findings suggest that closed‐loop vibration stimulation at +3% of the heart rate frequency before waking could be an effective method to reduce sleep inertia. This non‐invasive approach may facilitate cognitive recovery following sleep. Further research is required to investigate the underlying mechanisms, and confirm these findings across different populations and settings.
Legislator turnover and lobbyist exits
Authors: Strickland James M. 
Published: January 2025

AbstractTurnover among legislators encourages lobbyists to exit their profession since turnover is associated with decreased wages and increased workplace stress for lobbyists. I examine the exits of 5566 lobbyists who registered in eighteen states in 1973. Turnover among legislators is associated with increased rates of exit among lobbyists. I also test for whether various individual traits determine exit. Contrary to expectations, former legislators who lobby are not more likely to exit in response to turnover among incumbents than other lobbyists, including turnover in the chambers in which they served. These findings suggest that legislator turnover ends relationships with lawmakers or reduces skills among lobbyists, but that non‐revolver lobbyists are more affected by such turnover than others. These findings matter for institutional reforms that affect legislative turnover, and the representation of organized interests.
Perioperative management of a neonate with congenital biliary atresia complicated by severe pneumonia undergoing hepatic hilar jejunostomy: A case report
Authors: Zhang Hao , Zhang Mingjiao 
Published: January 2025

AbstractThe earlier a child with biliary atresia undergoes surgery after diagnosis, the better the prognosis. However, newborns often present with additional symptoms, most commonly pneumonia, which complicate in stabilizing the child's internal environment preoperatively, challenges anaesthetic management during surgery and hampers postoperative recovery. In current clinical practice, nursing care tends to focus more on symptomatic treatment rather than on a comprehensive pre‐ and postoperative assessment. This paper aimed to summarize the perioperative nursing experience of a neonate with biliary atresia and severe pneumonia. The study design of this article is a case report. After 17 days of intensive treatment and care, the child recovered and was discharged from the hospital, with ongoing progress noted during regular outpatient follow‐ups. A thorough nursing assessment encompassing preoperative, intraoperative and postoperative care for children with biliary atresia, along with clearly defined nursing priorities at each stage, is essential for safeguarding the child's well‐being throughout the perioperative period and supporting optimal postoperative recovery. This case study offers a comprehensive assessment of the child's condition throughout hospitalization. It highlights essential nursing interventions and monitoring strategies during the perioperative period, particularly preoperative and postoperative care. The insights gained can serve as a valuable reference for nursing practices in paediatric intensive care units, enhancing care for similar cases.
Awake Bruxism Is Unrelated to Smoking, Despite the Different Psychological Status: A Pilot Study
Authors: Saracutu Ovidiu Ionut , Manfredini Daniele , Bracci Alessandro , Ferrari Marco , Cagidiaco Edoardo Ferrari , Colonna Anna , Pollis Matteo 
Published: January 2025

ABSTRACTObjectiveThe aim of the present study is to get deeper into the complex interplay that might exist between awake bruxism (AB), tobacco smoking, and anxiety and/or depression symptoms in a group of healthy young adults.Materials and MethodsThe study participants were recruited by advertising the investigation at the University of Siena, Siena, Italy. The inclusion criteria were being in good general health, without systemic diseases or oral diseases. People with ongoing medical or dental treatment and those with a history of systemic disease or temporomandibular disorders were excluded. The participants who were included in the study received a questionnaire containing three sections for the assessment of AB behaviors, anxiety and depression symptoms, and the number of cigarettes smoked.ResultsA total of 141 healthy young adults met the inclusion criteria. Different awake masticatory muscle activities showed different strengths of association with anxiety and depression symptoms. However, no relationship was found between the number of smoked cigarettes and the frequency of the various masticatory muscle activities considered.ConclusionsThe result of the present study shows no clear‐cut association between the frequency of self‐reported AB behaviors and smoking in healthy individuals.
Buckwheat UDP‐Glycosyltransferase FtUGT71K6 and FtUGT71K7 Tandem Repeats Contribute to Drought Tolerance by Regulating Epicatechin Synthesis
Authors: Gao Yuanfen , Shi Yaliang , Jahan Tanzim , Huda Md. Nurul , Hao Lin , He Yuqi , Quinet Muriel , Chen Hui , Zhang Kaixuan , Zhou Meiliang 
Published: January 2025

ABSTRACTGlycosyltransferase genes are organised as tandem repeats in the buckwheat genome, yet the functional implications and evolutionary significance of duplicated genes remain largely unexplored. In this study, gene family analysis revealed that FtUGT71K6 and FtUGT71K7 are tandem repeats in the buckwheat genome. Moreover, GWAS results for epicatechin suggested that this tandem repeat function was associated with epicatechin content of Tartary buckwheat germplasm, highlighting variations in the promoter haplotypes of FtUGT71K7 influenced epicatechin levels. FtUGT71K6 and FtUGT71K7 were shown to catalyse UDP‐glucose conjugation to cyanidin and epicatechin. Furthermore, overexpression of FtUGT71K6 and FtUGT71K7 increased total antioxidant capacity and altered metabolite content of the epicatechin biosynthesis pathway, contributing to improved drought tolerance, while overexpression of FtUGT71K6 significantly improved salt stress tolerance. However, overexpression of these two genes did not contribute to resistance against Rhizoctonia solani. Evolutionary selection pressure analysis suggested positive selection of a critical amino acid ASP‐53 in FtUGT71K6 and FtUGT71K7 during the duplication event. Overall, our study indicated that FtUGT71K6 and FtUGT71K7 play crucial roles in drought stress tolerance via modulating epicatechin synthesis in buckwheat.
Elevated plasma testosterone concentrations from males on testosterone replacement therapy are mitigated with pathogen reduction technology
Authors: Greenwall B. , Reeder K. , Anani W. 
Published: January 2025

AbstractBackgroundDonors on testosterone replacement therapy (TRT) may require frequent whole blood donation due to erythrocytosis, but FDA guidelines prevent the transfusion of plasma‐based products from these donors. This study surveyed TRT donor testosterone levels in whole blood components and evaluated a possible mitigation strategy with a pathogen reduction technology using UVA light and compound adsorption device (CAD) steps.Study Design and MethodsWhole blood from male TRT donors and controls were processed into red blood cells and plasma components. Free and total testosterone were measured in 78 TRT donors and 48 controls by high‐performance liquid chromatography‐tandem mass spectrometry. Pathogen reduction (INTERCEPT Blood System) on pooled plasma components (n = 10) with supraphysiologic testosterone were sampled: before treatment, after UVA illumination, and after CAD incubation.ResultsTRT donors had 3.8 and 3.9 times more free testosterone in plasma and red blood cell supernatant, respectively, and 2.3 times more total testosterone in both components than controls (p < .0001). Two controls and 33 TRT donors had supraphysiologic testosterone. The CAD incubation reduced the mean free and total testosterone by 88% (571.72–73.8 pg/mL) and 84% (1498.61–240.59 ng/mL), respectively (p = .0065), but UVA light had no effect (p > .9999).DiscussionTRT donors had significantly higher testosterone levels than controls. The CAD step in the pathogen reduction process abrogated supraphysiologic testosterone in plasma at or below the reference range. Studies validating testosterone removal from plasma can support the transfusion of pathogen‐reduced plasma and platelets from TRT donors.
Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial
Authors: Wei Daimin , Sun Yun , Zhao Han , Yan Junhao , Zhou Hong , Gong Fei , Zhang Aijun , Wang Ze , Jin Lei , Bao Hongchu , Zhao Shuyun , Xiao Zhuoni , Qin Yingying , Geng Ling , Cui Linlin , Sheng Yan , Sun Mei , Liu Peihao , Ding Lingling , Liu Hong , Wu Keliang , Li Yan , Lu Yao , Xu Bufang , Xu Bei , Zhang Luqing , Zhang Heping , Legro Richard S , Chen Zi-Jiang 
Published: January 2025

Abstract

Objective
To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment.

Design
Pragmatic, multicentre, randomised controlled trial.

Setting
Nine academic fertility centres in China.

Participants
838 women with a low prognosis for IVF treatment defined by ≤9 oocytes retrieved or poor ovarian reserve (antral follicle count <5 or serum anti-Müllerian hormone level <8.6 pmol/L).

Interventions
Eligible participants were randomised (1:1) to undergo either frozen embryo transfer or fresh embryo transfer on the day of oocyte retrieval. Participants in the frozen embryo transfer group had all of their embryos cryopreserved and underwent frozen embryo transfer later. Participants in the fresh embryo transfer group underwent fresh embryo transfer after oocyte retrieval.

Main outcome measures
The primary outcome was live birth, defined as the delivery of neonates with a heartbeat and respiration at ≥28 weeks’ gestation. Secondary outcomes were clinical pregnancy, singleton or twin pregnancy, pregnancy loss, ectopic pregnancy, birth weight, maternal and neonatal complications, and cumulative live birth after embryo transfers within one year after randomisation.

Results

In an intention-to-treat analysis, the rate of live birth was lower in the frozen embryo transfer group than in the fresh embryo transfer group (32% (132 of 419)
v
40% (168 of 419); relative ratio 0.79 (95% confidence interval 0.65 to 0.94); P=0.009). The frozen embryo group had a lower rate of clinical pregnancy than the fresh embryo group (39% (164 of 419)
v
47% (197 of 419); 0.83 (0.71 to 0.97)). The cumulative live birth rate was lower in the frozen embryo transfer group compared with the fresh embryo transfer group (44% (185 of 419)
v
51% (215 of 419), 0.86 (0.75 to 0.99)). No difference was observed in birth weight, incidence of obstetric complications, or risk of neonatal morbidities.

Conclusions
Fresh embryo transfer may be a better choice for women with low prognosis in terms of live birth rate compared with a freeze-all strategy. The treatment strategies that prevent fresh embryo transfers, such as accumulating embryos with back-to-back cycles or performing routine preimplantation genetic testing for aneuploidy, warrant further studies in women with a low prognosis.

Trial registration
Chinese Clinical Trial Registry ChiCTR2100050168.
Medication-related hospitalisations in patients with SLE
Authors: Stanciu Michèle , Lee Joo-Young Esther , McDonald Emily G , Clark Gregory , Pineau Christian A , Kalache Fares , Grenier Louis-Pierre , Vinet Évelyne , Bernatsky Sasha , Mendel Arielle 
Published: January 2025

ObjectivesPatients with SLE take multiple medications. Within a large prospective longitudinal SLE cohort, we characterised medication-related hospitalisations and their preventability.MethodsWe identified consecutive admissions to our tertiary hospitals between 2015 and 2020. Two independent adjudicators evaluated if medication-related events contributed to the hospitalisation, considering (1) adverse drug events (ADEs) and (2) events from medication non-adherence, using the Leape and Bates method. We classified ADEs as potentially preventable/ameliorable if we identified modifiable factors. Logistic regressions with generalised estimating equations evaluated associations between participant characteristics and medication-related hospitalisations, accounting for repeat hospitalisations within the same participant.ResultsWe studied 68 hospitalisations among 45 participants (91% female). At first hospitalisation, the median age was 38 years (IQR 26.5–53.0) and median SLE duration was 12 years (IQR 5.5–19.5). One or more ADEs contributed to 20 (29%) hospitalisations (11/23 (48%) ADEs being preventable/ameliorable), and SLE flares associated with medication non-adherence contributed to 7 (10%) hospitalisations. Adjusting for age and sex, current prednisone use (adjusted OR (aOR) 3.7, 95% CI 1.1 to 13.0) or ≥1 current immunosuppressant (aOR 11.5, 95% CI 2.7 to 50.0), renal involvement at SLE diagnosis (aOR 6.5, 95% CI 2.7 to 15.7) and polypharmacy (≥5 medications; aOR 11.3, 95% CI 1.2 to 103.8) were associated with having an ADE-related (vs non-ADE) hospitalisation. Age at SLE diagnosis<18 years (OR 5.9, 95% CI 1.3 to 26.6) was associated with hospitalisation for a flare related to non-adherence.ConclusionForty per cent of SLE hospitalisations were medication-related, while half were potentially preventable/ameliorable. Renal involvement, polypharmacy, prednisone and immunosuppressant use were associated with hospitalisation related to an ADE, highlighting a vulnerable group.
Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases
Authors: Yamaji Fuminori , Fukuta Tetsuya , Ichihashi Masahiro , Mizuno Yosuke , Suzuki Keiko , Miyake Takahito , Kanda Norihide , Okada Hideshi 
Published: January 2025

BackgroundSmall bowel injuries are rare in trauma. Diagnosing these injuries is difficult owing to the lack of clear signs, and delays in diagnosis might increase complications and mortality. Trauma can damage the vascular endothelial glycocalyx, with syndecan-1 emerging as a marker of injury. Here, we describe two cases of small bowel injury due to traffic motor vehicle crash trauma.Case presentationThe patients, one in their 40s and one teenaged, were transported to our hospital after a traffic motor vehicle crash. Both patients were wearing seat belts at the time of the motor vehicle crash, and the car’s airbags deployed properly. Their vital signs were stable at admission, and non-operative treatment was selected. However, their abdominal pain did not improve, and based on posthospitalization CT reconstructive imaging, intra-abdominal hemorrhage was suspected. Surgery was performed, revealing small intestinal injuries. In both patients, a high serum syndecan-1 level in the blood test at admission was a common characteristic.ConclusionIncreased serum syndecan-1 level was observed in blood tests during the initial treatment of small intestinal injuries in these patients, suggesting its potential utility in early diagnosis. However, further accumulation of cases and detailed studies are required to substantiate these results.
Analytical investigation of the mass spectrum of tetraquarks with a relativistic approach
Authors: Ghasempour A. , Tazimi N. , Monemzadeh M. 
Published: January 2025

Abstract
In this paper, we study four-body systems and consider them as diquark–antidiquark. We use the Bethe–Salpeter equation (Schrödinger equation with relativistic kinematics) to calculate the binding energies and the mass of heavy tetraquarks with hidden charm and bottom structures. To solve the Bethe–Salpeter equation, we use the Hellmann potential and the Ansatz method and calculate the mass of tetraquarks X(3.872), Y(3.940),

$$Z_{cs}(3.985),$$

Z

cs

(
3.985
)

,

X(4.140),

$$Z_{b}(10.610),$$

Z
b

(
10.610
)

,

and

$$Z_{b}(10.650).$$

Z
b

(
10.650
)

.

Our results are in good agreement with theoretical and experimental data.
Positive energy density in topologically charged exponential wormholes and Regge–Wheeler potential
Authors: Ahmed Faizuddin , Goswami Jaydeep , Bouzenada Abdelmalek 
Published: January 2025

Abstract
In this paper, we investigate a series of topologically charged exponential traversable wormhole models described by the standard metric form:

$$\begin{aligned}ds^2=-\mathcal {A}^2(r)\,dt^2+\mathcal {B}^2(r)\,\left[ \frac{dr^2}{\alpha ^2}+r^2\,(d\theta ^2+\sin ^2\theta \,d\phi ^2)\right] ,\end{aligned}$$

d

s
2

=
-

A

2

(
r
)

d

t
2

+

B

2

(
r
)

d

r
2

α
2

+

r
2

(
d

θ
2

+

sin
2

θ

d

ϕ
2

)

,

where

$$0< \alpha < 1$$

0
<
α
<
1

is the global monopole chare parameter. We focus on the positivity of the energy density across these models, defined by the following functions: (i)

$$\mathcal {A}(r)=\exp \left( -\frac{M}{r}\right) $$

A

(
r
)

=
exp

-

M
r

and

$$\mathcal {B}(r)=\exp \left( \frac{M}{r}+\beta \,r\right) $$

B

(
r
)

=
exp

M
r

+
β

r

, (ii)

$$\mathcal {A}(r)=\exp \left( -\frac{M}{r}-\gamma \,r\right) $$

A

(
r
)

=
exp

-

M
r

-
γ

r

and

$$\mathcal {B}(r)=\exp \left( \frac{M}{r}\right) $$

B

(
r
)

=
exp

M
r

, and (iii)

$$\mathcal {A}(r)=\exp \left( -\frac{M}{r}-\gamma \,r\right) $$

A

(
r
)

=
exp

-

M
r

-
γ

r

and

$$\mathcal {B}(r)=\exp \left( \frac{M}{r}+\beta \,r\right) $$

B

(
r
)

=
exp

M
r

+
β

r

, where

$$M, \beta $$

M
,
β

and

$$\gamma $$

γ

are constants. For each model, we evaluate key properties such as the wormhole throat radius, geometric stability, and energy conditions. Additionally, we analyze geodesic motions of test particle around a generalized wormhole, highlighting how the presence of the global monopole parameter affects trajectories of test particles within this topologically charged wormhole. Our results demonstrate that the radius of the wormhole throat is consistent with established characteristics of traversable wormholes and is free from singularities. subsequently, we study the Regge–Wheeler (RW) potential in the context of our chosen wormhole background, providing a detail analysis of its implications for spin zero scalar s-waves with multipole number

$$\ell =0$$

ℓ
=
0

. our analysis shows that the RW potential for spin zero scalar field is influence by the global monopole parameter and the coupling constant, which possesses dimensions inverse to that of length present in the wormhole space-time geometry. This modification has profound implications for the stability and dynamics of scalar perturbations in the vicinity of the wormhole, potentially affecting the stability of the wormhole itself.
Notes on integrating out M2 branes
Authors: Hattab Jarod , Palti Eran 
Published: January 2025

Abstract
Integrating out supersymmetric M2 branes wrapped on two-cycles in Calabi–Yau manifolds is an important calculation: it allows the determination of, and in some ways defines, the free energy of topological strings. In these notes, based on a short course aimed at graduate students, we go through various aspects of this calculation in detail. The end result is a recently proposed new formula for the topological string free energy.
Polarized $$W^+W^-$$ pairs at the LHC: Effects from bottom-quark induced processes at NLO QCD + EW
Authors: Dao Thi Nhung , Le Duc Ninh 
Published: January 2025

Abstract
We investigate the effects of the bottom-quark induced processes on the doubly polarized cross sections of

$$W^+W^-$$

W
+

W
-

pair production at the LHC. The method to extract the on-shell single-top contribution is provided. Results for phenomenological and experimental analyses are given at next-to-leading order (NLO) QCD + EW accuracy, with the leading contribution from the gluon–gluon and photon–photon fusion included. We found that the contribution of the bottom-quark induced processes, after the subtraction of the on-shell tW channel, is largest for the doubly longitudinal polarization. At the integrated cross section level, using a fiducial ATLAS cut with a jet veto, the effect is

$$9\%$$

9
%

compared to the NLO value of the light-quark contribution. It increases to

$$13\%$$

13
%

after removing the jet veto. A bound of the tW interference is calculated for various kinematic distributions, showing that this interference effect is, in general, smaller for the no jet veto case. Relevant scale uncertainties are calculated to help us decide on the importance of this interference.