bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paeoniflorin shows chondroprotective effects under IL-1β stress by regulating circ-PREX1/miR-140-3p/WNT5B axis
Authors: Wu Lan’e , Tang Runke , Xiong Weibiao , Song Shuhua , Guo Qian , Zhang Qingqing 
Published: October 2023

Abstract
Background
Osteoarthritis (OA) is a chronic and degenerative bone and joint disease, and paeoniflorin shows anti-arthritis role in OA. This study planned to investigate the mechanism related to chondroprotective role of paeoniflorin in OA.

Methods
Real-time quantitative PCR and western blotting were performed to measure expression levels of circ-PREX1, microRNA (miR)-140-3p, Wingless-type MMTV integration site family, member 5B (WNT5B), B cell lymphoma (Bcl)-2, and Bcl-2 Associated X Protein (Bax). MTT assay, EdU assay, flow cytometry and enzyme-linked immunosorbent assay evaluated cell viability, proliferation, apoptosis and inflammatory response, respectively. Dual-luciferase reporter assay and RNA immunoprecipitation assay identified the relationship among circ-PREX1, miR-140-3p, and WNT5B.

Results
IL-1β highly induced apoptosis rate, Bax expression and TNF-α product, accompanied with decreased cell viability, cell proliferation and IL-10 secretion, whereas these effects were partially reversed after paeoniflorin pretreatment. Expression of circ-PREX1 was upregulated and miR-140-3p was downregulated in cartilage tissues of patients with knee OA (KOA) and IL-1β-induced human chondrocytes (C28/I2). Circ-PREX1 overexpression and miR-140-3p silencing attenuated the suppressive effect of paeoniflorin in IL-1β-induced C28/I2 cells. Furthermore, miR-140-3p was negatively regulated by circ-PREX1. WNT5B was a downstream target of miR-140-3p and could be modulated by the circ-PREX1/miR-140-3p pathway in IL-1β-induced C28/I2 cells.

Conclusion
Paeoniflorin might protect human chondrocytes from IL-1β-induced inflammatory injury via circ-PREX1-miR-140-3p-WNT5B pathway, suggesting a potential preventative agent and a novel target for the treatment of KOA.
Acute cardiac tamponade following thoracoscopic lobectomy: a case report and literatures review
Authors: Chen Wei , Shen Yi , Yuan Yang , Zheng Qiangqiang , Zhou Yunfeng 
Published: October 2023

AbstractThoracoscopic lobectomy is a common surgical procedure for the treatment of lung cancer. With the continuous development of surgical techniques and medical devices, complications after thoracoscopic lobectomy are less and less, and cardiac tamponade is even rarer. This case is a 62-year-old woman who underwent thoracoscopic left upper lobectomy for a left upper lobe nodule. The patient developed acute cardiac tamponade on postoperative day 2, and symptoms resolved after pericardiocentesis. However, 20 h later, the patient underwent emergency surgery for re-developed acute cardiac tamponade, which was found to be a coronary tear. A review of the literature suggested that cardiac tamponade is more common in left lung surgery than right lung surgery. Pericardiocentesis can resolve initial acute cardiac tamponade, but pericardiotomy may be urgently needed after recurrence.
Case report of non-tracheal intubation—an alternative for postpneumonectomy patients undergoing contralateral pulmonary resection
Authors: Deng Jingdan , Zeng Zhiwen , Zhang Zizheng 
Published: October 2023

Abstract
Background
Surgery on the contralateral or other lungs after pneumonectomy on one side is highly challenging and complex. It is critical to creating conditions for fluent surgical maneuvers while ensuring adequate ventilation for a patient during such an operation in the same chest cavity that appears incompatible.

Case presentation
We have reported herein the case of a patient who, following a left pneumonectomy, underwent a right upper pulmonary nodule wedge resection via video-assisted thoracoscopic surgery without requiring endotracheal intubation. We managed ventilation with a laryngeal mask airway under general anesthesia combined with a thoracic epidural block. The diseased lobe collapsed well for the surgical procedure during VATS without hypoxia, after which the resection was safely performed.

Conclusions
Non-tracheal intubation anesthesia can be a potentially attractive alternative for patients undergoing contralateral pulmonary resection after pneumonectomy.
Total arch replacement for an aortic arch aneurysm with cold agglutinin disease after rituximab and plasmapheresis
Authors: Mitsuishi Atsuyuki , Miura Yujiro , Saeki Kyosuke , Nomura Yoshinori , Yoshifumi Katsumata , Yoshida Keisuke 
Published: October 2023

Abstract
Background
Cold agglutinin disease can lead to significant complications, especially for patients undergoing arch repair requiring hypothermic circulatory arrest. Rituximab and plasmapheresis are treatments for cold agglutinin disease. However, its use in patients with Stanford type A dissection has not been reported. Therefore, after consultation with hematologists, we used rituximab and plasmapheresis before mild hypothermic aortic arch surgery to maintain the body temperature above the thermal altitude.

Case presentation
This report describes an 86-year-old male patient with acute type A aortic dissection who received outpatient treatment for rheumatoid arthritis and a 55-mm thoracic aortic aneurysm. The patient was scheduled to undergo urgent surgery for a type A intramural hematoma and progressive aortic aneurysm; however, laboratory test results indicated blood clotting and cold agglutinin. Consequently, urgent surgery was rescheduled. After consulting with hematologists, rituximab was initiated 3 months before surgery, and plasmapheresis was performed 2 days before surgery for cold agglutinin disease. Under mild hypothermia conditions, total arch replacement using the frozen elephant trunk technique was performed while maintaining cerebral and lower body perfusion. The postoperative course was uneventful. On postoperative day 42, the patient was discharged without any neurological deficits.

Conclusions
This case involving total arch replacement with mild hypothermia for an aortic arch aneurysm with cold agglutinin disease after rituximab treatment and plasmapheresis resulted in a successful outcome.
Implementing digital mental health interventions at scale: one-year evaluation of a national digital CBT service in Ireland
Authors: Harty Siobhán , Enrique Angel , Akkol-Solakoglu Selin , Adegoke Adedeji , Farrell Hannah , Connon Graham , Ward Fiona , Kennedy Conor , Chambers Derek , Richards Derek 
Published: October 2023

Abstract
Background
In recent years, exponential growth in digital innovations and internet access has provided opportunities to deliver health services at a much greater scale than previously possible. Evidence-based technology-enabled interventions can provide cost-effective, accessible, and resource-efficient solutions for addressing mental health issues. This study evaluated the first year of a supported digital cognitive behavioral therapy (CBT) service provided by the national health service in Ireland, which has been accessible to individuals who receive a referral from one of five referring groups: General Practitioners, Primary Care Psychology, Counselling Primary Care, Community Mental Health, and Jigsaw (a nationwide youth mental health service).

Methods
A retrospective, observational study examining data from the service between April 2021 to April 2022 was conducted. Descriptive statistics on referrals, account activations, user demographics, program usage, and user satisfaction were extracted, and pre-to-post clinical outcomes for depression measured by the Patient Health Questionnaire-9 and for anxiety measured by the Generalised Anxiety Disorder-7 were analysed using linear mixed effect models.

Results
There were 5,298 referrals and 3,236 (61%) account activations within the year. Most users were female (72.9%) and aged between 18 and 44 years (75.4%). The CBT programs were associated with significant reductions in both depression (β = 3.34, 95% CI [3.03, 3.65], p < 0.001) and anxiety (β = 3.64, 95% CI [3.36, 3.93], p < 0.001), with large effect sizes (Cohen’s d > 0.8). Time spent using the programs was also found to be a predictor of the variability in these clinical outcomes (p < 0.001), and accounting for this resulted in significantly better model fits (p < 0.001). User satisfaction ratings were also very high, exceeding 94%.

Conclusions
Efforts to improve the representation of male and older adult users are warranted. However, overall, the results demonstrate how digital CBT can be provided at scale and lead to symptom reductions with large effect sizes for patients seeking help for depression and anxiety. The findings substantiate the continued use and expansion of this service in Ireland and the more widespread implementation of similar services in other international public healthcare settings.
Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms
Authors: Sigurjonsdottir Gudbjörg , De Marchi Tommaso , Ehinger Anna , Hartman Johan , Bosch Ana , Staaf Johan , Killander Fredrika , Niméus Emma 
Published: October 2023

Abstract
Background
Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in triple-negative breast cancer (TNBC). However, IHC evaluation methods are non-uniform and further studies are needed to optimize clinical utility.

Methods
We compared the concordance, prognostic value and gene expression between PD-L1 IHC expression by SP142 immune cell (IC) score and 22C3 combined positive score (CPS; companion IHC diagnostic assays for atezolizumab and pembrolizumab, respectively) in a population-based cohort of 232 early-stage TNBC patients.

Results
The expression rates of PD-L1 for SP142 IC ≥ 1%, 22C3 CPS ≥ 10, 22C3 CPS ≥ 1 and 22C3 IC ≥ 1% were 50.9%, 27.2%, 53.9% and 41.8%, respectively. The analytical concordance (kappa values) between SP142 IC+ and these three different 22C3 scorings were 73.7% (0.48, weak agreement), 81.5% (0.63) and 86.6% (0.73), respectively. The SP142 assay was better at identifying 22C3 positive tumors than the 22C3 assay was at detecting SP142 positive tumors. PD-L1 (CD274) gene expression (mRNA) showed a strong positive association with all two-categorical IHC scorings of the PD-L1 expression, irrespective of antibody and cut-off (Spearman Rho ranged from 0.59 to 0.62; all p-values < 0.001). PD-L1 IHC positivity and abundance of tumor infiltrating lymphocytes were of positive prognostic value in univariable regression analyses in patients treated with (neo)adjuvant chemotherapy, where it was strongest for 22C3 CPS ≥ 10 and distant relapse-free interval (HR = 0.18, p = 0.019). However, PD-L1 status was not independently prognostic when adjusting for abundance of tumor infiltrating lymphocytes in multivariable analyses.

Conclusion
Our findings support that the SP142 and 22C3 IHC assays, with their respective clinically applied scoring algorithms, are not analytically equivalent where they identify partially non-overlapping subpopulations of TNBC patients and cannot be substituted with one another regarding PD-L1 detection.
Trial registration The Swedish Cancerome Analysis Network - Breast (SCAN-B) study, retrospectively registered 2nd Dec 2014 at ClinicalTrials.gov; ID NCT02306096.
Are non-starters accumulating enough load compared with starters? Examining load, wellness, and training/match ratios of a European professional soccer team
Authors: Oliveira Rafael , Canário-Lemos Rui , Morgans Ryland , Rafael-Moreira Tiago , Vilaça-Alves José , Brito João Paulo 
Published: October 2023

Abstract
Background
The aims of the study were to: (i) compare accumulated load and wellness between starters and non-starters of a European professional soccer team; (ii) analyze the relationships between wellness and load measures and; (iii) compare training/match ratio (TMr) of external and internal load between starters and non-starters.

Methods
Ten players were considered starters while seven were classified as non-starters over a 16-week period in which six training sessions and match day (MD) were considered in each weekly micro-cycle. The following measures were used: wellness (fatigue, quality of sleep, muscle soreness, stress, and mood); load (rated of perceived exertion (RPE), session-RPE (s-RPE), high-speed running (HSR), sprinting, accelerations (ACC) and decelerations (DEC)). Accumulated wellness/load were calculated by summing all training and match sessions, while TMr was calculated by dividing accumulated training load by match data for all load measures and each player. Mann–Whitney U test was used for wellness variables, while independent T-test was used for the remaining variables to compare groups. Moreover, relationships among variables were explored using the Spearman’s Rho correlation coefficient.

Results
The main results showed that non-starters presented higher significant values for fatigue (p < 0.019; g = 0.24) and lower significant values for duration (p < 0.006; ES = 1.81) and s-RPE (p < 0.001; ES = 2.69) when compared to starters. Moreover, positive and very large correlation was found between quality of sleep and RPE, while negative and very large correlation were found between stress and deceleration, and mood and deceleration (all, p < 0.05). Finally, non-starters presented higher values in all TMr than starters, namely, RPE (p = 0.001; g = 1.96), s-RPE (p = 0.002; g = 1.77), HSR (p = 0.001; g = 2.02), sprinting (p = 0.002; g = 4.23), accelerations (p = 0.001; g = 2.72), decelerations (p < 0.001; g = 3.44), and duration (p = 0.003; g = 2.27).

Conclusions
In conclusion, this study showed that non-starters produced higher TMr in all examined variables despite the lower match and training durations when compared with starters, suggesting that physical load was adjusted appropriately. Additionally, higher RPE was associated with improved sleep while higher number of decelerations were associated with decreased wellness, namely, stress and mood for non-starters.
MapReduce scheduling algorithms in Hadoop: a systematic study
Authors: Hedayati Soudabeh , Maleki Neda , Olsson Tobias , Ahlgren Fredrik , Seyednezhad Mahdi , Berahmand Kamal 
Published: October 2023

AbstractHadoop is a framework for storing and processing huge volumes of data on clusters. It uses Hadoop Distributed File System (HDFS) for storing data and uses MapReduce to process that data. MapReduce is a parallel computing framework for processing large amounts of data on clusters. Scheduling is one of the most critical aspects of MapReduce. Scheduling in MapReduce is critical because it can have a significant impact on the performance and efficiency of the overall system. The goal of scheduling is to improve performance, minimize response times, and utilize resources efficiently. A systematic study of the existing scheduling algorithms is provided in this paper. Also, we provide a new classification of such schedulers and a review of each category. In addition, scheduling algorithms have been examined in terms of their main ideas, main objectives, advantages, and disadvantages.
Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER
Authors: Yang Jingjing , Guo Kaibo , Zhang Anlai , Zhu Ying , Li Wendi , Yu Jieru , Wang Peipei 
Published: October 2023

Abstract
Background
This research aimed to investigate the prognostic factors of oral squamous cell carcinoma (OSCC), especially the role of age.

Methods
A total of 33,619 cases of OSCC were received from the Surveillance, Epidemiology, and End Results (SEER) database during 2005–2015. Kaplan–Meier curves of 5-year overall survival rates and 5-year cancer-specific survival rates were performed, and univariate and multivariate Cox regression analyses as well as competing risk model were used to help understand the relationship between various factors and mortality of OSCC.

Results
Compared to 18–39-year-old group, the older age was an important predictor of worse prognosis. The multivariate analysis of overall survival (OS) was 50–59 years (HR, 1.32; 95% CI 1.17–1.48; p ≤ .001), 60–69 years (HR, 1.66; 95% CI 1.42–1.87; p ≤ .001) and 70 + years (HR, 3.21; 95% CI 2.86–3.62; p ≤ .001), respectively, while the specific value of competing risk model was 60–69 years (HR, 1.21; 95% CI 1.07–1.38; p = .002) and 70 + years (HR, 1.85; 95% CI 1.63–2.10; p ≤ .001). In addition, female gender, unmarried, Blacks, tumor in floor of mouth, size and higher Tumor Node Metastasis (TNM) classification were also other predictors that signify significant clinically deterioration of OS/cancer-specific survival (CSS).

Conclusions
Our research revealed that age was an important factor in explaining the difference of survival in the whole process of OSCC. It is suggested that we should pay attention to the influence of age on diagnosis, treatment and prognosis in the clinical process.
Nomogram for predicting survival in patients with mucinous breast cancer undergoing chemotherapy and surgery: a population-based study
Authors: Gao Ting , Chen Yuyuan , Li Ming , Zhu Keying , Guo Rong , Tang Yiyin , Huang Sheng , Chen Dedian 
Published: October 2023

Abstract
Background
The prognosis of patients with mucinous breast cancer (MuBC) is affected by several factors, but the low incidence of MuBC makes it difficult to conduct extensive and in-depth studies. This study was designed to establish a prognostic model and verify its accuracy in patients with MuBC after chemotherapy and surgery to help develop personalized treatment strategies.

Materials and methods
Patients with MuBC who underwent chemotherapy and surgery from 2004 to 2015 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors of patients with MuBC were investigated using a Cox proportional hazards regression analysis. Based on the identified factors, a nomogram was constructed to forecast the overall survival (OS) of patients at 3, 5, and 10 years. Internal (from SEER) and external (from Yunnan Cancer Center, YNCC) verification queues were used to verify the nomogram and demonstrate the predictive capacity of this model.

Results
The study comprised 1668 MuBC patients from the SEER database and 107 from the YNCC. The nomogram included four characteristics: age, anatomical stage, surgical method, and radiotherapy. The concordance indices in the training, internal verification, and external verification queues were 0.680, 0.768, and 0.864, respectively. The calibration curves for the nomogram showed excellent agreement between the predictions and observations. This nomogram has good clinical application value according to the decision curve analysis.

Conclusions
The prognosis of patients with MuBC who have undergone chemotherapy and surgery can be forecasted using this nomogram, which would be beneficial to help create individualized treatment plans for the affected patients.
An analysis of protesting activity and trauma through mathematical and statistical models
Authors: Rodríguez Nancy , White David 
Published: October 2023

AbstractThe effect that different police protest management methods have on protesters’ physical and mental trauma is still not well understood and is a matter of debate. In this paper, we take a two-pronged approach to gain insight into this issue. First, we perform statistical analysis on time series data of protests provided by ACLED and spanning the period of time from January 1, 2020, until March 13, 2021. After observing the data, it becomes apparent that employing kinetic impact projectiles is correlated with an increase in protests in the following days. Moreover, it serves as a more accurate indicator of the subsequent death toll compared to the mere number of protests. This leads to the conclusion that the utilization of less-lethal weapons appears to provoke rather than quell protests, exhibiting an inflammatory effect. Next, we provide a mathematical framework to model modern, but well-established social psychology research on compliance theory and crowd dynamics. Our results show that understanding the heterogeneity of the crowd is key for protests that lead to a reduction of social tension and minimization of physical and mental trauma in protesters.
The longitudinal directional associations of meaningful work with mental well-being – initial findings from an exploratory investigation
Authors: Herr Raphael M. , Brokmeier Luisa , Baron Bertil N. , Mauss Daniel , Fischer Joachim E. 
Published: October 2023

Abstract
Background
An increasing number of studies reveal that more meaning in life is positively related to mental well-being. Meaning in life can be derived from different sources, including the workplace. The aim of this study was to explore the longitudinal directional association of meaningful work with mental well-being.

Methods
Prospective data from 292 persons at two timepoints (two-week interval) were used to estimate the cross-lagged relationship and directionality of meaningful work with mental well-being.

Results
The cross-lagged panel model had a good fit to the data (Chi2 ms(90) = 150.9; p < 0.001; RMSEA = 0.048; p = 0.576; CFI = 0.984; TLI = 0.979; SRMR = 0.040) and showed that levels of meaningful work at t1 had a positive effect on mental well-being at t2 (β = 0.15, p = 0.010). But mental well-being at t1 did not affect meaningful work at t2 (β = 0.02, p = 0.652). Sub-analyses revealed the effects to be mainly driven by women (as opposed to men) and white-collar workers (as opposed to blue-collar workers).

Conclusion
This study confirmed a directional association of meaningful work on mental well-being, indicating that more meaningful work has beneficial mental well-being effects.
Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue
Authors: Banovic Ingrid , Scrima Fabrizio , Fornasieri Isabelle , Beaugerie Laurent , Coquart Jérémy , Fourgon Chloé , Iodice Pierpaolo , Nion-Larmurier Isabelle , Savoye Guillaume , Sorin Anne-Laure , Tourny Claire , Augustinova Maria 
Published: October 2023

Abstract
Background
Psychometric validation of the Multidimensional Chronic Asthenia Scale (MCAS) was conducted in order to provide an effective tool for assessing the health-related quality of life of French-speaking patients with chronic asthenia (CA).

Methods
Items resulting from the initial formulation of the self-reported MCAS (along with other materials) were completed by French-speaking volunteers with inactive or active inflammatory bowel disease (IBD-I vs. IBD-A) or chronic fatigue syndrome (CFS). Responses from 621 participants (180 patients with IBD-A, 172 with IBD-I, 269 with CFS) collected in a single online survey were divided into three subsamples to test the construct validity of the MCAS (Step 1, N = 240), to confirm its factorial structure (Step 2, N = 204) and to explore its convergent-discriminant validity with the Fatigue Symptoms Inventory (FSI) and revised Piper Fatigue Scale (r-PFS, Step 3, N = 177).

Results
Steps 1 and 2 showed that, as expected, MCAS has four dimensions: feeling of constraint (FoC), physical (PC), life (LC) and interpersonal consequences (IC), which are also related to the duration of CA (i.e., the longer it lasts, the more the dimensions are impacted). The results further showed that the MCAS is sensitive enough to capture between-group differences, with the CFS group being the most impaired, followed by IBD-A and IBD-I. While convergent-discriminant validity between the 4 factors of MCAS and FSI and r-PFS, respectively, was satisfactory overall, Step 3 also pointed to some limitations that call for future research (e.g., shared variances between the PC and IC dimensions of MCAS and behavioral dimension of r-PFS).

Conclusion
Despite these limitations, the MCAS clearly constitutes a promising tool for measuring quantitative differences (i.e., severity/intensity) in CA associated with various diseases, but also, and importantly, the clinically important differences in domains of its expression (i.e., qualitative differences).