bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of work-related fall injuries resulting in hospitalisation: individual and work risk factors and severity
Authors: Wah Win , Berecki-Gisolf Janneke , Walker-Bone Karen 
Published: January 2024

ObjectivesInjuries at work are common and costly for individuals and employers. A common mechanism of workplace injury is through falls, but there have been few epidemiological studies of risk factors. This study aimed to identify patient, work and injury factors associated with injuries causing hospitalisation after falling at work in Victoria, Australia.MethodsData came from work-related hospitalised injury admissions, identified by International Classification of Diseases and Related Health Problems, Tenth Revision Australian Modification codes and compensation status, from Victorian Admitted Episodes Dataset between 1 July 2017 and 30 June 2022. Multivariate logistic regression analyses were conducted to identify factors associated with same-level falls and falls from height.ResultsThis study included 42 176 work-related injury admissions: 8669 (20.6%) fall injuries and 33 507 (79.4%) other injuries. Rates of high falls were more common in males than females (0.44 (95% CI: 0.43, 0.46) vs 0.08 (0.08, 0.09) admissions per 1000 employed), while same-level falls were more common in females than males (0.21 (0.20, 0.22) vs 0.18 (0.17, 0.18)). Patients with same-level fall injuries, relative to all other work injuries, were more likely to be older women, and have at least one chronic condition; falls from height were associated with male sex and construction work and more likely to result in intracranial, internal organ injuries and fractures and longer hospital stay than non-fall injuries.ConclusionWork-related falls were common and relatively severe. Same-level falls are relatively likely to occur in older women, the fastest-growing workplace demographic, and therefore the incidence is expected to increase. Comorbidities are an important fall risk factor. Employers could consider industry-relevant high and same-level fall prevention strategies for reducing the workplace injury burden.
Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study
Authors: Yavropoulou Maria P , Filippa Maria G , Vlachogiannis Nikolaos I , Fragoulis George E , Laskari Katerina , Mantzou Aimilia , Panopoulos Stylianos , Fanouriakis Antonis , Bournia Vasiliki-Kalliopi , Evangelatos Gerasimos , Papapanagiotou Aggeliki , Tektonidou Maria G , Chrousos George P , Sfikakis Petros P 
Published: January 2024

ObjectivesA reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation (disproportion principle) has been observed in rheumatoid arthritis (RA). We examined the possible clinical value of diurnal cortisol measurements in active RA on treatment response prediction.MethodsDiurnal cortisol production (measured at: 08–12:00/18:00–22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls.ResultsSaliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold higher serum C reactive protein (CRP) levels, and lower than COVID-19 patients (area under the curve: RA: 87.0±37.6 vs COVID-19: 146.7±14.3, p<0.001), having similarly high CRP. Moreover, a disturbed circadian cortisol rhythm at baseline was evident in 15 of 28 of patients with RA vs 4 of 28 and 20 of 28 of HC and COVID-19 patients, respectively. Treatment-induced minimal disease activity (MDA) at 6 months was achieved by 16 of 28 patients. Despite comparable demographics and clinical characteristics at baseline, non-MDA patients had lower baseline morning cortisol and higher adrenocorticotropic hormone (ACTH) levels compared with patients on MDA (cortisol: 10.9±4.0 vs 18.4±8.2 nmol/L, respectively, p=0.005 and ACTH: 4.8±3.3 vs 2.4±0.4 pmol/L, respectively, p=0.047). Baseline morning cortisol <13.9 nmol/L predicted non-MDA at 6 months (75% sensitivity, 92% specificity, p=0.006). Prospective measurements revealed that individualised diurnal cortisol production remained largely unchanged from baseline to 3 and 6 months.ConclusionsAn impaired adrenal reserve is present in patients with RA. Further studies to confirm that assessment of diurnal cortisol production may be useful in guiding treatment decisions and/or predicting treatment response in RA are warranted.Trial registration numberNCT05671627.
Risk of Gastric Adenocarcinoma in a Multiethnic Population Undergoing Routine Care: An Electronic Health Records Cohort Study
Authors: Huang Robert J. , Huang Edward S. , Mudiganti Satish , Chen Tony , Martinez Meghan C. , Ramrakhiani Sanjay , Han Summer S. , Hwang Joo Ha , Palaniappan Latha P. , Liang Su-Ying 
Published: January 2024

Abstract

Background:
Gastric adenocarcinoma (GAC) is often diagnosed at advanced stages and portends a poor prognosis. We hypothesized that electronic health records (EHR) could be leveraged to identify individuals at highest risk for GAC from the population seeking routine care.

Methods:
This was a retrospective cohort study, with endpoint of GAC incidence as ascertained through linkage to an institutional tumor registry. We utilized 2010 to 2020 data from the Palo Alto Medical Foundation, a large multispecialty practice serving Northern California. The analytic cohort comprised individuals ages 40–75 receiving regular ambulatory care. Variables collected included demographic, medical, pharmaceutical, social, and familial data. Electronic phenotyping was based on rule-based methods.

Results:
The cohort comprised 316,044 individuals and approximately 2 million person-years (p-y) of observation. 157 incident GACs occurred (incidence 7.9 per 100,000 p-y), of which 102 were non-cardia GACs (incidence 5.1 per 100,000 p-y). In multivariable analysis, male sex [HR: 2.2, 95% confidence interval (CI): 1.6–3.1], older age, Asian race (HR: 2.5, 95% CI: 1.7–3.7), Hispanic ethnicity (HR: 1.9, 95% CI: 1.1–3.3), atrophic gastritis (HR: 4.6, 95% CI: 2.2–9.3), and anemia (HR: 1.9, 95% CI: 1.3–2.6) were associated with GAC risk; use of NSAID was inversely associated (HR: 0.3, 95% CI: 0.2–0.5). Older age, Asian race, Hispanic ethnicity, atrophic gastritis, and anemia were associated with non-cardia GAC.

Conclusions:
Routine EHR data can stratify the general population for GAC risk.

Impact:
Such methods may help triage populations for targeted screening efforts, such as upper endoscopy.
Carta para Joaquim José da Cruz
Authors: Pereira Gabriela Acerbi 
Published: January 2024

Este ensaio é composto por uma carta escrita pela autora e por três colagens feitas a partir do acervo pessoal de Joaquim José da Cruz, o último Moçambique que viveu na cidade de Poços de Caldas, no Sul de Minas Gerais. Ele dançou nos festejos para São Benedito, Nossa Senhora do Rosário e Santa Ifigênia por mais de sessenta anos. Poucos meses antes da sua partida, ele desejou ter suas imagens e seu acervo pessoal passados a diante. Esse ensaio faz parte da realização desse pedido.
Entrevista com a profa. Dra. Marilda Aparecida de Menezes
Authors: Magalhães Valéria Barbosa de 
Published: January 2024

“A história oral é uma metodologia de uma riqueza e uma potencialidade enormes, que se combina com uma perspectiva de migrações centrada nos sujeitos sociais, centrada nos migrantes e não nos processos”
A entrevista foi realizada nos dias 28 de fevereiro e 13 de agosto de 2019, por Valéria Barbosa de Magalhães, no âmbito do projeto de pesquisa Nordestinos em São Paulo e História Oral: Abordagem histórico-crítica, com vigência 2017 a 2020, financiado pela Fapesp e coordenado por Valéria B. Magalhães. Transcrição: Aline Campos dos Reis (bolsista TT Fapesp) e Andréa Moreira Santana (bolsista PUB/USP). Conferência: Valéria B. Magalhães.
Humanitarian Public Diplomacy in Comparative Perspective: The 2015 Refugee Crisis (2015-2021), the Syrian Civil War (2011-2022) and the 2015 Nepal Earthquake
Authors: Dingott Alkopher Tal , Barak Naama 
Published: January 2024

Summary
The aim of the article is to enhance understanding of the phenomenon of humanitarian public diplomacy in relation to digital communication strategics. It aspires to grasp the nature of discursive practices and strategies of public communications used by practitioners of humanitarian diplomacy. The article analytically maps discursive practices and strategies of public communications employed by humanitarian international organisations across humanitarian crisis cases and explains similarities and differences across cases. Three contexts of humanitarian crisis were chosen as case studies: the humanitarian crisis resulting from the war in Syria (2011-2022); the refugee-related humanitarian crisis in the Mediterranean (2015-2021); and the humanitarian crisis that accompanied the Nepal earthquake in 2015.
Bee Movie
Authors: Denton Andrew , Gibbons Andrew 
Published: January 2024

Abstract
Bee Movie is a short film that invites questions for conversations on visual ethics. The viewer is invited into a world of circular, tragic and absurd questions concerning what a filmmaker, an abstract writer, a journal editor, and a film viewer ought to do when observing the apparent reality of a bee’s circular attempts to escape a pond. As a filmmaker and abstract writer, one does not want to tell the viewer and reader how one feels about this bee, bees, insects, ponds, water, life, death and circles. And one feels obliged not to explain the context through which the film came to life as the bee was engaged in efforts that might be narrated as lifesaving but also as another complex of efforts entirely. As an open image, without our textual dissection (or, at least, with a dampening of that dissection to an abstract and with a few questions and challenges), we regard Bee Movie as inviting questions about the ethics of the use of images as pedagogy. Whatever we thought about whether and how to share this film, we find ourselves in 359 other relationships, and always back again to what we assumed might be the starting position.
What Visibilising Pedagogical Approaches do the Chinese as a Foreign Language (cfl) Teachers Adopt in the Teaching of Chinese Characters?
Authors: Yu Jinghan , Fletcher Jo , Everatt John , Astall Chris 
Published: January 2024

Abstract
Chinese can be considered as one of the more challenging languages to learn for many non-native learners. Its complicated visual script, the Chinese characters, demands that teachers be proficient in utilizing diverse visual pedagogical approaches, coupled with different digital visual tools, to enhance their teaching effectiveness. Adopting a descriptive qualitative analysis method, interview transcripts from fourteen cfl teachers were examined. There were five online teachers, four university teachers and five pre-service teachers. The findings revealed that: 1) all the teachers use various visual pedagogical approaches, such as pictures, videos, Chinese character digital image files, Chinese character studying applications, and websites, to enhance the effectiveness of Chinese character learning, as well as motivate and engage learners; 2) teachers choose different pedagogical approaches to help students visualise characters as a whole unit or as several separate radical components; 3) the use of Pinyin to input characters on digital devices has been widely taught in class; and 4) online teachers, and some pre-service teachers, have replaced traditional handwriting methods with digital character input methods, whereas university teachers have not made this shift. The ways in which these perspectives relate to the form of Chinese characters and developing teaching practices are discussed.
Impact of cucurbit crop management techniques on the foraging behavior of honeybees and hoverflies in Morogoro, Tanzania
Authors: Rweyemamu Elvillah William , Mwatawala Maulid Walad , Tryphone George Muhamba , De Meyer Marc , Kabota Sija , Bwire Patroba Masatu 
Published: January 2024

Abstract
Background
Poor agricultural practices have drastically threatened insect pollinators’ biodiversity. Little is known in Tanzania about how different agricultural practices affect pollinators’ foraging behavior. This study investigated the effects of the agroecological zone, season, cucurbit species and management practices on visitation frequency, visitation rate and time spent on cucurbit flowers by five pollinator species viz. Apis mellifera, Eristalinus megacephalus, Mesembrius caffer, Paragus borbonicus and Toxomerus floralis. The experiment was designed as a 5 × 3 × 3 × 2 × 2 factorial arrangement in a Randomized Complete Block Design (RCBD) with four replications. GAMOUR-Agroecology was tested against conventional practices and untreated control.

Results
This study revealed significant effects of agroecological zone × season × cucurbit species × management practice on pollinators’ visitation frequency (p = 0.007) and time spent on flowers (p = 0.005). Also, agroecological zone × season × cucurbit species × pollinator species significantly (p < 0.0001) affected pollinators’ visitation frequency. Agroecological zones × season × cucurbit species × cucurbits management practices × pollinators significantly (p = 0.001) affected pollinators’ visitation rate. Apis mellifera was the most frequent visitor in Cucurbita moschata plots treated with GAMOUR- Agroecology in the plateau zone, also, visited higher number of Cucumis sativus plots under GAMOUR-Agroecology practices in the mountainous zone during the October–November season. Furthermore, it has been found that pollinators spent much in cucurbit flowers on plots with GAMOUR-Agroecology practices and control.

Conclusions
Pollinators’ foraging behavior were enhanced by GAMOUR-Agroecology practices. Therefore, this study recommended that cucurbit growers should consider management practices that positively influence pollinator foraging activities for sustainable cucurbit production.
Genomic data integration tutorial, a plant case study
Authors: Mardoc Emile , Sow Mamadou Dia , Déjean Sébastien , Salse Jérôme 
Published: January 2024

Abstract
Background
The ongoing evolution of the Next Generation Sequencing (NGS) technologies has led to the production of genomic data on a massive scale. While tools for genomic data integration and analysis are becoming increasingly available, the conceptual and analytical complexities still represent a great challenge in many biological contexts.

Results
To address this issue, we describe a six-steps tutorial for the best practices in genomic data integration, consisting of (1) designing a data matrix; (2) formulating a specific biological question toward data description, selection and prediction; (3) selecting a tool adapted to the targeted questions; (4) preprocessing of the data; (5) conducting preliminary analysis, and finally (6) executing genomic data integration.

Conclusion
The tutorial has been tested and demonstrated on publicly available genomic data generated from poplar (Populus L.), a woody plant model. We also developed a new graphical output for the unsupervised multi-block analysis, cimDiablo_v2, available at https://forgemia.inra.fr/umr-gdec/omics-integration-on-poplar, and allowing the selection of master drivers in genomic data variation and interplay.
Effects of propofol versus sevoflurane on surgical field visibility during arthroscopic rotator cuff repair: a randomized trial
Authors: Yin Wenchao , Yin Chenzhu , Wang Wencan , Peng Rao , Su Li , Li Peiyu 
Published: January 2024

Abstract
Background
During arthroscopic rotator cuff repair (ARCR), clear surgical field visibility (SFV) is the basis of successful surgery, but the choice of anesthesia maintenance drugs may have different effects on SFV. In this study, we aimed to compare the effects of propofol- and sevoflurane-based general anesthesia on SFV in patients undergoing ARCR.

Methods
Patients (n = 130) undergoing elective ARCR in the lateral decubitus position were randomized into either the propofol group or sevoflurane group (65 per group). The duration of surgery and increased pressure irrigation (IPI), Boezaart score, rocuronium consumption and usage of remifentanil were recorded. The time of both spontaneous respiration recovery and extubation and the incidences of postoperative nausea and vomiting and agitation were also recorded.

Results
The Boezaart score, duration of IPI and ratio of the duration of IPI to the duration of surgery (IPI/S ratio) were similar between the groups (P > 0.05). Rocuronium consumption, number of patients requiring remifentanil infusion and total remifentanil consumption were significantly lower in the sevoflurane group (P < 0.05). The spontaneous respiration recovery time was significantly longer in the propofol group (P < 0.05), but there were no differences in the extubation time between the groups(P > 0.05).

Conclusions
Compared with propofol, sevoflurane provides equally clear SFV while improving the convenience of anesthesia maintenance in ARCR patients with interscalene plexus (ISB) combined with general anesthesia.

Trial registration
This single-center, prospective, RCT was retrospective registered at Chinese Clinical Trial Registry with the registration number ChiCTR2300072110 (02/06/2023).
Heterogeneity by age and gender in the association of kidney function with mortality among patients with diabetes - analysis of diabetes registry in Singapore
Authors: Jafar Tazeen H. , Seng Loraine Liping , Wang Yeli , Lim Ching Wee , Chan Choong Meng , Kwek Jia Liang , Coffman Thomas M. , Ping Yongjing , Bee Yong Mong , Allen John C. 
Published: January 2024

Abstract
Background
We aimed to explore the three-way interaction among age, gender, and kidney function on the risk of all-cause mortality and cardiovascular mortality among patients with type 2 diabetes (T2D).

Methods
In a retrospective cohort study, patients aged > 40 years with T2D with serum creatinine and urine albumin measured from 2013 to 2019 were included from a multi-institutional diabetes registry. The exposure was estimated glomerular filtration rate (eGFR), outcomes were all-cause mortality (primary outcome) and cardiovascular disease (CVD) mortality (secondary outcome). We applied multivariable cox proportional hazards regression analysis to compute the association between eGFR and mortality.

Results
A total of 36,556 patients were followed for up to 6 years during which 2492 (6.82%) died from all causes, and 690 (1.9%) died from CVD. We observed a significant three-way interaction (p = 0.021) among age (younger, < 65; older, ≥65 years), gender and eGFR for the risk of all-cause mortality. Using age- and gender-specific eGFR of 90 ml/min/1.73m2 as the reference point, the adjusted hazard rate (HR) (95% CI) for all-cause mortality at eGFR of 40 ml/min/1.73m2 was 3.70 (2.29 to 5.99) in younger women and 1.86 (1.08 to 3.19) in younger men. The corresponding adjusted HRs in older women and older men were 2.38 (2.02 to 2.82) and 2.18 (1.85 to 2.57), respectively. Similar results were observed for CVD deaths, although the three-way interaction was not statistically significant. Sensitivity analysis yielded similar results.

Conclusions
In this T2D population, younger women with reduced kidney function might be more susceptible to higher risks of all-cause mortality and CVD mortality than younger men.
The comparison of pure uterine serous carcinoma and mixed tumor with serous component: a single-institution review of 91 cases
Authors: You Xuewu , Dong Yangyang , Wang Jiaqi , Cheng Yuan , Jia Yuanyuan , Zhang Xiaobo , Wang Jianliu 
Published: January 2024

Abstract
Background
Pure uterine serous carcinoma (p-USC) and mixed tumors with serous component (m-USC) are aggressive subtypes of endometrial cancer associated with high mortality rates. This retrospective study aimed to compare clinicopathologic features and outcomes of p-USC and m-USC in a single center.

Methods
This study retrospectively reviewed patients diagnosed with USC at Peking University People’s Hospital between 2008 and 2022. T-tests and chi-square tests were used to compare clinicopathological characteristics between p-USC and m-USC. Kaplan-Meier survival curve and Cox regression analysis were used to analyze the impact of clinical and pathological variables on OS and PFS.

Results
Among the 91 patients who underwent surgery, 65.9% (n = 60) were p-USC, and 34.1% (n = 31) were m-USC. Patients with p-USC had earlier menopause (P = 0.0217), a lower rate of progesterone receptor(PR) expression (P < 0.001), and were more likely to have positive peritoneal cytology (P = 0.0464). After a median follow-up time of 40 months, 28 (46.7%) p-USC and 9 (29%) m-USC patients had progression disease, 18 (30%) and 8 (25.8%) patients died of their disease. 5-year PFSR were 51.2% and 75.3%, respectively, and 5-year OS rates were 66% and 67.4%. Kaplan-Meier survival analysis showed that p-USC was more likely to relapse than m-USC (P = 0.034), but there was no significant difference in OS. Cox regression analysis showed that lymph node metastasis and surgical approach were risk factors for OS, and myoinvasion depth ≥ 1/2 was an independent risk factor for PFS.

Conclusions
p-USC was more likely to relapse than m-USC, but there was no significant difference in OS between the two subtypes.
EMP3 as a prognostic biomarker correlates with EMT in GBM
Authors: Li Li , Xia Siyu , Zhao Zitong , Deng Lili , Wang Hanbing , Yang Dongbo , Hu Yizhou , Ji Jingjing , Huang Dayong , Xin Tao 
Published: January 2024

Abstract
Background
Glioblastoma (GBM) is the most aggressive malignant central nervous system tumor with a poor prognosis.The malignant transformation of glioma cells via epithelial-mesenchymal transition (EMT) has been observed as a main obstacle for glioblastoma treatment. Epithelial membrane protein 3 (EMP3) is significantly associated with the malignancy of GBM and the prognosis of patients. Therefore, exploring the possible mechanisms by which EMP3 promotes the growth of GBM has important implications for the treatment of GBM.

Methods
We performed enrichment and correlation analysis in 5 single-cell RNA sequencing datasets. Differential expression of EMP3 in gliomas, Kaplan–Meier survival curves, diagnostic accuracy and prognostic prediction were analyzed by bioinformatics in the China Glioma Genome Atlas (CGGA) database and The Cancer Genome Atlas (TCGA) database. EMP3-silenced U87 and U251 cell lines were obtained by transient transfection with siRNA. The effect of EMP3 on glioblastoma proliferation was examined using the CCK-8 assay. Transwell migration assay and wound healing assay were used to assess the effect of EMP3 on glioblastoma migration. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot were used to detect the mRNA and protein expression levels of EMT-related transcription factors and mesenchymal markers.

Results
EMP3 is a EMT associated gene in multiple types of malignant cancer and in high-grade glioblastoma. EMP3 is enriched in high-grade gliomas and isocitrate dehydrogenase (IDH) wild-type gliomas.EMP3 can be used as a specific biomarker for diagnosing glioma patients. It is also an independent prognostic factor for glioma patients' overall survival (OS). In addition, silencing EMP3 reduces the proliferation and migration of glioblastoma cells. Mechanistically, EMP3 enhances the malignant potential of tumor cells by promoting EMT.

Conclusion
EMP3 promotes the proliferation and migration of GBM cells, and the mechanism may be related to EMP3 promoting the EMT process in GBM; EMP3 may be an independent prognostic factor in GBM.