bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy lifestyle and cancer survival: A multinational cohort study
Authors: Bian Zilong , Zhang Rongqi , Yuan Shuai , Fan Rong , Wang Lijuan , Larsson Susanna C. , Theodoratou Evropi , Zhu Yimin , Wu Shouling , Ding Yuan , Li Xue 
Published: January 2024

AbstractLifestyle factors after a cancer diagnosis could influence the survival of cancer 60 survivors. To examine the independent and joint associations of healthy lifestyle factors with mortality outcomes among cancer survivors, four prospective cohorts (National Health and Nutrition Examination Survey [NHANES], National Health Interview Survey [NHIS], UK Biobank [UKB] and Kailuan study) across three countries. A healthy lifestyle score (HLS) was defined based on five common lifestyle factors (smoking, alcohol drinking, diet, physical activity and body mass index) that related to cancer survival. We used Cox proportional hazards regression to estimate the hazard ratios (HRs) for the associations of individual lifestyle factors and HLS with all‐cause and cancer mortality among cancer survivors. During the follow‐up period of 37,095 cancer survivors, 8927 all‐cause mortality events were accrued in four cohorts and 4449 cancer death events were documented in the UK and US cohorts. Never smoking (adjusted HR = 0.77, 95% CI: 0.69–0.86), light alcohol consumption (adjusted HR = 0.86, 95% CI: 0.82–0.90), adequate physical activity (adjusted HR = 0.90, 95% CI: 0.85–0.94), a healthy diet (adjusted HR = 0.69, 95% CI: 0.61–0.78) and optimal BMI (adjusted HR = 0.89, 95% CI: 0.85–0.93) were significantly associated with a lower risk of all‐cause mortality. In the joint analyses of HLS, the HR of all‐cause and cancer mortality for cancer survivors with a favorable HLS (4 and 5 healthy lifestyle factors) were 0.55 (95% CI 0.42–0.64) and 0.57 (95% CI 0.44–0.72), respectively. This multicohort study of cancer survivors from the United States, the United Kingdom and China found that greater adherence to a healthy lifestyle might be beneficial in improving cancer prognosis.
Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation
Authors: Feng Yiyuan , Xu Zhongyun , Jin Hongfu , Chen Yuanyuan , Fu Chenglai , Zhang Yu , Yin Yafu , Wang Hui , Cheng Weiwei 
Published: January 2024

AbstractAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective cure. GGGGCC repeat expansion in C9orf72 is the most common genetic cause of both ALS and FTD. A key pathological feature of C9orf72 related ALS/FTD is the presence of abnormal dipeptide repeat proteins translated from GGGGCC repeat expansion, including poly Glycine‐Arginine (GR). In this study, we observed that (GR)50 conferred significant mitochondria damage and cytotoxicity. Metformin, the most widely used clinical drug, successfully relieved (GR)50 induced mitochondrial damage and inhibited (GR)50 related cytotoxicity. Further research revealed metformin effectively restored mitochondrial function by upregulating AKT phosphorylation in (GR)50 expressed cells. Taken together, our results indicated restoring mitochondrial function with metformin may be a rational therapeutic strategy to reduce poly(GR) toxicity in C9orf72 ALS/FTD patients.
Platelet‐rich plasma does not accelerate the healing of damaged muscle following muscle strain
Authors: Fusagawa Hiroyori , Yamada Takashi , Sato Tatsuya , Ashida Yuki , Teramoto Atsushi , Takashima Hiroyuki , Naito Azuma , Tokuda Nao , Yamauchi Nao , Ichise Nobutoshi , Ogon Izaya , Yamashita Toshihiko , Tohse Noritsugu 
Published: January 2024

AbstractAlthough platelet‐rich plasma (PRP) has been widely used regardless of the severity of muscle strain, there have been very few basic studies in which its effects on muscle injury were examined by using models that accurately mimic the clinical muscle strain injury process. Therefore, the aim of this study was to confirm by physiological and structural analyses whether PRP purified by a general preparation method has a muscle healing effect on muscle damage caused by eccentric contraction (ECC). Male Wistar rats were subjected to muscle injury induced by ECC in bilateral plantar flexor muscles using electrical stimulation and an automatically dorsiflexing footplate. The rats were randomly assigned to three groups by type of injection: phosphate‐buffered saline (PBS), leukocyte‐poor PRP (LP‐PRP), or leukocyte‐rich PRP (LR‐PRP) injection into gastrocnemius muscles three times at weekly intervals. The platelet concentrations of the LP‐PRP and LR‐PRP were three to five times higher than that of whole blood. The recovery process of torque strength in the plantar flexor muscle, signal changes in MRI images, and histological evaluation 3 weeks after injury showed no obvious differences among the three groups, and every muscle recovered well from the injury without marked fibrosis. The results that neither LP‐PRP nor LR‐PRP was found to accelerate healing of muscle injuries suggested that conventional preparation and use of PRP for simple muscle injuries caused by muscle strain should be carefully considered, and further basic research using models that accurately mimic clinical practice should be carried out to determine the optimal use of PRP.
(Resonance) Raman optical activity among chiroptical spectroscopies: Quo vadis?
Authors: Halat Monika , Pajor Katarzyna , Baranski Rafal , Baranska Malgorzata 
Published: January 2024

AbstractAlthough the potential of Raman Optical Activity (ROA) spectroscopy in the field of organic and inorganic materials research has been well demonstrated, its practical application is still limited. This work shows historical background, current state of the art and challenges of ROA spectroscopy facing scientists today. Expectations and development prospects for the coming years are also discussed. Efforts have already been made to improve but also to properly interpret the ROA signal when the ROA technique is combined with other spectroscopies (i.e., ROA/Electronic Circular Dichroism and ROA/Circularly Polarized Luminescence). The paper shows how to intensify the ROA effect to shorten the spectrum accumulation time, control possible artefacts and support the analysis of ROA spectra with actual and new theoretical approaches. However, the challenge is to increase the interest in this technique among the academic community, develop reliable protocols and adapt them for practical use. National and international research networks can significantly contribute to the growth of methodologies and standardization in areas in which the ROA has so far been little used. This paper presents a perspective vision for the future progress of ROA alongside other chiroptical methods.
Trauma exposure and transdiagnostic distress: Examining shared and posttraumatic stress disorder–specific associations
Authors: Crowe Michael L. , Hawn Sage E. , Wolf Erika J. , Keane Terence M. , Marx Brian P. 
Published: January 2024

AbstractWe examined transdiagnostic and posttraumatic stress disorder (PTSD)–specific associations with multiple forms of trauma exposure within a nationwide U.S. sample (N = 1,649, 50.0% female) of military veterans overselected for PTSD. A higher‐order Distress factor was estimated using PTSD, major depressive disorder (MDD), and generalized anxiety disorder (GAD) symptoms as indicators. A structural equation model spanning three assessment points over an average of 3.85 years was constructed to examine the unique roles of higher‐order Distress and PTSD‐specific variance in accounting for the associations between trauma exposure, measured using the Life Events Checklist (LEC) and Deployment Risk and Resiliency Inventory Combat subscale (DRRI‐C), and psychosocial impairment. The results suggest the association between trauma exposure and PTSD symptoms was primarily mediated by higher‐order distress (70.7% of LEC effect, 63.2% of DRRI‐C effect), but PTSD severity retained a significant association with trauma exposure independent of distress, LEC: β = .10, 95% CI [.06, .13]; DRRI‐C: β = .11, 95% CI [.07, .14]. Both higher‐order distress, β = .31, and PTSD‐specific variance, β = .36, were necessary to account for the association between trauma exposure and future impairment. Findings suggest that trauma exposure may contribute to comorbidity across a range of internalizing symptoms as well as to PTSD‐specific presentations.
Simulation and parameter extraction of flying‐bird motion echo based on laser micro‐Doppler effect
Authors: Yang Zhen , Jiao Dan , Dai Xin , Zhang Yong , Zhang Jianlong 
Published: January 2024

AbstractTo solve the problem of target recognition for flying‐birds and biomimetic flapping‐wing unmanned aerial vehicles (UAVs), a rectangular‐trapezoidal composite scattering model for lidar detection of bird wings has been proposed and established. According to the model, the influence of different line‐of‐sight angles on the time–frequency distribution characteristics of laser micro‐Doppler under the same flapping wing motion was simulated and studied. Then, the flapping‐wing frequency and maximum frequency shift are extracted based on the two‐dimensional Fourier transform and the least squares method. When signal noise ratio = 5 dB, the accuracy rate of flapping‐wing frequency extraction can reach at 100%, the maximum relative error of frequency shift for inner contour extraction is less than 3.0%, and the maximum relative error of frequency shift for outer contour extraction is less than 7.2%.
Assisted reproductive technology and physical activity among Chinese pregnant women at high risk for gestational diabetes mellitus in early pregnancy: A cross‐sectional study
Authors: Chen Lu , Deng Yong‐Fang , Fan Mei‐Qiong , Yuan Hao Bin , Meng Li‐Rong , Gao Ling‐Ling 
Published: January 2024

AbstractCurrently, the number of pregnant women at high risk for gestational diabetes mellitus (GDM) and using assisted reproductive technology (ART) is increasing. The present study aims to explore the relationship between ART and physical activity in Chinese pregnant women at high risk for GDM in early pregnancy. A cross‐sectional study was conducted in a regional teaching hospital in Guangzhou, China, between July 2022 and March 2023. Three hundred fifty‐five pregnant women at high risk for GDM in early pregnancy completed the Chinese version of the Pregnant Physical Activity Questionnaire (PPAQ), the Pregnancy Physical Activity Knowledge Scale, the Pregnancy Physical Activity Self‐Efficacy Scale, the Pregnancy Physical Activity Social Support Scale, and a sociodemographic and obstetric characteristics data sheet. Compared to women who conceived naturally, women who used ART were more likely to be 35 years or older, unemployed, primigravidae, and to have intentionally planned their pregnancies. Women who used ART had significantly lower levels of physical activity and self‐efficacy compared to their counterparts who conceived naturally. Over half (55.6%) of women who used ART reported being physically inactive, and those with lower self‐efficacy, as well as the unemployed, were significantly more likely to be inactive. Physical inactivity is a critical clinical issue among women who use ART, especially in the context of GDM risk. Future research should develop and test physical activity programs, including enhancing physical activity self‐efficacy for women who use ART. Patient or public contribution: In this study, survey questionnaires were completed by participants among Chinese pregnant women at high risk for GDM in early pregnancy.
Net prices of new antiobesity medications
Authors: Hernandez Inmaculada , Sullivan Sean D. 
Published: January 2024

AbstractObjectiveGlucagon‐like peptide‐1 receptor agonists (GLP1s) are effective antiobesity drugs and the subject of intense debate around insurance coverage due to the large prevalence of obesity and overweight. The estimation of the budget impact associated with GLP1 insurance coverage requires estimates of GLP1 prices that account for manufacturer discounts. The authors applied a peer‐reviewed method to estimate the net prices of GLP1s after manufacturer discounts.MethodsThe authors estimated manufacturer discounts for each product as the difference between the gross sales estimated at list price and manufacturer‐reported revenue. From this difference, the authors subtracted discounts to government programs, including 340B, Medicaid, and the Medicare Part D coverage gap, and attributed the remaining amount to manufacturer discounts provided in the commercial market.ResultsManufacturer discounts for GLP1s approved for obesity were estimated at 41%, which translated into net prices of $717 to $761 per month of supply. Manufacturer discounts for GLP1s approved for type 2 diabetes ranged from 54% to 59%, which translated into net prices of $312 to $469 per month of supply.ConclusionsThe magnitude of manufacturer discounts underscores the need to consider net price information in studies that inform private and public payers' decision‐making around coverage of GLP1s for obesity.
Making Waves: The Role of Indigenous Water Beings in Debates about Human and Non‐Human Rights
Authors: Strang Veronica 
Published: January 2024

ABSTRACTRejecting nature‐culture dualism, contemporary anthropology recognises the mutually constitutive processes that create shared human and non‐human lifeworlds. Such recognition owes much to ethnographic engagement with diverse indigenous cosmologies many of which have, for millennia, upheld ideas about indivisible worlds in which all living kinds occupy a shared ontological space and non‐human species and environments are approached respectfully, with expectations of reciprocity and partnership. As many societies confront the global chaos caused by the anthropocentric prioritisation of human interests, anthropologists and indigenous communities are therefore well placed to articulate alternative models in which the non‐human domain is dealt with more equitably and inclusively. This paper is located comparatively in long‐term ethnographic research with indigenous communities in Australia, alongside the Mitchell River in North Queensland and the Brisbane River in South Queensland. It draws more specifically on involvement in legal claims for water rights by Māori iwis in New Zealand; in land claims by the Kunjen language group in Cape York; and in a recent ‘sea country’ case brought against a major multi‐national by the Tiwi Islanders in Australia's Northern Territory. It also makes use of a major comparative study of water beings in diverse cultural and historical contexts, and considers the central importance of water beings such as Māori taniwha and the Australian Rainbow Serpent in such legal conflicts, and in broader debates about human and non‐human rights. Like other water deities around the world, these beings personify the generative (and potentially punitive) powers of water and its co‐creative role in shaping human and non‐human lives. They are resurfacing today with an important representational role in contemporary conflicts over land and water.
Initial Experience With Robotic‐Assisted Otologic and Lateral Skull Base Surgery
Authors: Garcia Alejandro , Shave Samantha , Cheng Yew S. , Santos Felipe , Quesnel Alicia , Cohen Michael S. , Lee Daniel J. 
Published: January 2024

AbstractRobotic‐assisted surgery has gained popularity for otolaryngology procedures. It provides high‐definition images and surgical precision to perform diverse procedures. It is an alternative to the operating microscope, endoscope, or exoscope when reaching hidden anatomical structures in the ear. In this proof‐of‐concept study, we aim to demonstrate the possibility of using a robotic‐assisted device to perform ear surgery in conjunction with the microscope or the endoscope. In total, there were 9 ear and lateral skull base procedures performed with the use of robotic‐assisted surgery. All surgeons underwent surveys to assess the performance and workload of the device compared to the microscope or endoscope. There were no postoperative complications. Robotic‐assisted surgery was optimal for providing high image quality, ergonomics, and maintaining surgical performance. The size of the device and mental demand were higher compared to the microscope or endoscope. Robotic‐assisted surgery can be an adjuvant to perform otologic and neurotologic surgery.
Registration of ‘Coastcross II’ forage bermudagrass
Authors: Anderson William F. , Powell Jerrel , Hanna Wayne W. , Burton Glenn , Davis M. 
Published: January 2024

Abstract‘Coastcross II’ (CC II; Reg. no. CV‐49, PI 673409) forage bermudagrass (Cynodon sp.) was released as an associate cultivar in Georgia in July 2014. Coastcross II originated from gamma‐ray irradiation of sprigs of Coastcross I (CC I) in 1971. After irradiation, greater than a half million sprigs were planted in north Georgia (Blairsville), where CC II was one of four surviving plants after winter freezes. Subsequent testing has shown that CC II has superior yields to CC I and is comparable to ‘Tifton 85’. Coastcross II also has significantly higher tolerance to bermudagrass stem maggot than fine‐stemmed cultivars. Coastcross II has significantly finer stems than Tifton 85, which makes it more conducive to hay production.
Effects of a peer‐led physical activity program on psychosocial outcomes among breast cancer survivors
Authors: Pinto Bernardine M. , Dunsiger Shira I. , Kindred Madison , Mitchell Sheryl , DeScenza Victoria 
Published: January 2024

AbstractObjectiveTo examine the effects of three programs aimed at maintaining moderate‐to‐vigorous physical activity (MVPA) on breast cancer survivors' quality of life, physical functioning, fatigue and mood.Methods161 survivors participated in a 12‐month randomized controlled study and were assigned to one of three groups: Reach Plus, Reach Plus Message, or Reach Plus Phone. All participants received the same intervention for the first 3 months (weekly calls from peer coach) for MVPA adoption. In Months 4–9, Reach Plus monitored MVPA and received feedback reports. Reach Plus Message monitored MVPA and received weekly text/email messages and feedback reports. Reach Plus Phone participants monitored MVPA and received monthly calls from coaches and feedback reports. Intervention delivery ended at 9 months. Assessments were obtained at baseline, 3, 6, 9, and 12‐months. Analyses used a series of longitudinal mixed effects models with subject‐specific intercepts.ResultsAll groups improved significantly across time on psychosocial measures. At 9 months, Reach Plus Message and Reach Plus Phone reported better physical functioning compared to Reach Plus (b = 8.27, 95% CI: [2.27, 14.27]; b = 4.89, 95% CI: [0.01, 10.53]) respectively). At 12 months, Reach Plus Message reported better physical functioning than Reach Plus (b = 4.52, 95% CI: [0.01, 9.75]. Participants who met national PA guidelines reported significantly lower fatigue and higher physical functioning (at 9 and 12 months), and improved mood (at 12 months).ConclusionsMVPA maintenance via weekly messages or monthly coach calls improved physical functioning. Maintaining MVPA at or above national recommendations was associated with improved physical functioning, mood and less fatigue.
Development of a question prompt list for Indian cancer patients receiving radiation therapy treatment and their primary family caregivers
Authors: Chawak Shweta , Chittem Mahati , Dhillon Haryana , Huligol Nagraj , Butow Phyllis 
Published: January 2024

AbstractAimWe aimed to develop two question prompt lists (QPLs), one for Indian cancer patients undergoing radiation therapy and the second for their primary family caregivers.MethodsThe study comprised three phases: (1) qualitative interviews with patients (n = 65) and PFCs (n = 39) to identify their information needs, queries and concerns regarding RT; (2) development of draft QPLs using conventional content analysis and translation into Hindi and Marathi using European Organisation Research and Treatment of Cancer guidelines; and, (3) A readability analysis, and acceptability study with patients (n = 22), PFCs (n = 26) and Radiation Oncology (RO) staff (n = 20) exploring barriers to QPL implementation.Results and DiscussionAnalysis in Phase I identified questions patients and PFCs asked or wanted to ask their physician. A list of 125 and 136 questions were generated for patients and PFCs, respectively. After five iterations, the draft QPLs were finalised, translated, and back‐translated from English into Hindi and Marathi (Phase II). In Phase III, most patients and PFCs reported the QPLs were easy to read, they did not find it difficult to ask the questions, and the questions were not emotionally upsetting. Conversely, RO staff reported concerns that patients may find it difficult to discuss the questions with their physician.ConclusionThe study highlights the need to empower patients and PFCs to ask questions and for staff to feel comfortable answering them. Implementing physician‐endorsed QPLs could achieve these aims.
Inclusive education and school dropout of special needs students in Morocco: A spatial analysis
Authors: Ibourk Aomar , Raoui Soukaina 
Published: January 2024

AbstractAs a specific driver for the transformation of education systems in Morocco, inclusive education is a process that aims to reduce the exclusion of children with disabilities. Indeed, few studies have analysed the exclusion factors that cause children with disabilities not to pursue their education. Based on this, the present paper explores the spatial effect of factors related to accessibility and school supply. The database is from the latest national survey of the 2014 General Census of Population and Housing for the 75 provinces of Morocco. The designated age group is children aged 10–14 years. Exploratory spatial analysis has allowed us to map the hotspots of school dropout risk. The results of the spatial heterogeneity show a deficit in the distribution of accessibilities and the supply of paramedical services. From economic policy, we emphasise the need for spatial equity in the geographic distribution of inclusive education provision. The equitable distribution of psychological conditions for school retention is a straightforward factor in the success of the inclusive education model in Morocco.
Set‐membership estimation of switched LPV systems: Application to fault/disturbance estimation
Authors: Zhang Shuang , Puig Vicenç , Ifqir Sara 
Published: January 2024

SummaryThis paper proposes a set‐membership state estimation method for Switched Linear Parameter Varying (SLPV) systems subject to unknown but bounded parametric uncertainties, disturbances and noises. A zonotopic outer approximation of the state estimation domain is computed at every time iteration. The size of this zonotope is designed to be convergent and bounded by satisfying ‐radius‐based and Average Dwell Time (ADT) conditions that are formulated in the Linear Matrix Inequality (LMI) framework. An extension of the state estimation method is presented to address the fault/disturbance estimation problem for SLPV systems. By using the state augmentation technique, the fault/disturbance estimation problem is transformed into a state estimation problem of the generated augmented descriptor switched LPV system. An application to vehicle lateral dynamics fault estimation is used for assessment purposes. Simulation results demonstrate the effectiveness of the proposed algorithm and highlight its advantages over the existing methods.