bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diurnally Varying Ekman Layer in a Rossby Wave
Authors: Shapiro Alan , Chiappa Jason , Parsons David B. 
Published: December 2023

Abstract
Weak but persistent synoptic-scale ascent may play a role in the initiation or maintenance of nocturnal convection over the central United States. An analytical model is used to explore the nocturnal low-level jets (NLLJ) and ascent that develop in an idealized diurnally varying frictional (Ekman) boundary layer in a neutrally stratified barotropic environment when the flow aloft is a zonally propagating Rossby wave. Steady-periodic solutions are obtained of the linearized Reynolds-averaged Boussinesq-approximated equations of motion on a beta plane with an eddy viscosity that is specified to increase abruptly at sunrise and decrease abruptly at sunset. Rayleigh damping terms are used to parameterize momentum loss due to radiation of inertia–gravity waves. The model-predicted vertical velocity is (approximately) proportional to the wavenumber and wave amplitude. There are two main modes of ascent in midlatitudes, an afternoon mode and a nocturnal mode. The latter arises as a gentle but persistent surge induced by the decrease of turbulence at sunset, the same mechanism that triggers inertial oscillations in the Blackadar theory of NLLJs. If the Rayleigh damping terms are omitted, the boundary layer depth becomes infinite at three critical latitudes, and the vertical velocity becomes infinite far above the ground at two of those latitudes. With the damping terms retained, the solution is well behaved. Peak daytime ascent in the model occurs progressively later in the afternoon at more southern locations (in the Northern Hemisphere) until the first (most northern) critical latitude is reached; south of that latitude the nocturnal mode is dominant.
An Investigation of LES Wall Modeling for Rayleigh–Bénard Convection via Interpretable and Physics-Aware Feedforward Neural Networks with DNS
Authors: Wang Aaron , Yang Xiang I. A. , Ovchinnikov Mikhail 
Published: December 2023

Abstract
The traditional approach of using the Monin–Obukhov similarity theory (MOST) to model near-surface processes in large-eddy simulations (LESs) can lead to significant errors in natural convection. In this study, we propose an alternative approach based on feedforward neural networks (FNNs) trained on output from direct numerical simulation (DNS). To evaluate the performance, we conduct both a priori and a posteriori tests. In the a priori (offline) tests, we compare the statistics of the surface shear stress and heat flux, computed from filtered DNS input variables, to the stress and flux obtained from the filtered DNS. Additionally, we investigate the importance of various input features using the Shapley additive explanations value and the conditional average of the filter grid cells. In the a posteriori (online) tests, we implement the trained models in the System for Atmospheric Modeling (SAM) LES and compare the LES-generated surface shear stress and heat flux with those in the DNS. Our findings reveal that vertical velocity, a traditionally overlooked flow quantity, is one of the most important input features for determining the wall fluxes. Increasing the number of input features improves the a priori test results but does not always improve the model performance in the a posteriori tests because of the differences in input variables between the LES and DNS. Last, we show that physics-aware FNN models trained with logarithmic and scaled parameters can well extrapolate to more intense convection scenarios than in the training dataset, whereas those trained with primitive flow quantities cannot.

Significance Statement
The traditional near-surface turbulence model, based on a shear-dominated boundary layer flow, does not represent near-surface turbulence in natural convection. Using a feedforward neural network (FNN), we can construct a more accurate model that better represents the near-surface turbulence in various flows and reveals previously overlooked controlling factors and process interactions. Our study shows that the FNN-generated models outperform the traditional model and highlight the importance of the near-surface vertical velocity. Furthermore, the physics-aware FNN models exhibit the potential to extrapolate to convective flows of various intensities beyond the range of the training dataset, suggesting their broader applicability for more accurate modeling of near-surface turbulence.
Hailfall in a Possible Future Climate Using a Pseudo–Global Warming Approach: Hail Characteristics and Mesoscale Influences
Authors: Mallinson Holly , Lasher-Trapp Sonia , Trapp Jeff , Woods Matthew , Orendorf Sophie 
Published: December 2023

Abstract
Severe convective storms (SCS) and their associated hazards present significant societal risk. Understanding of how these hazards, such as hailfall, may change due to anthropogenic climate change is in its infancy. Previous methods used to investigate possible changes in SCS and their hail used climate model output and were limited by their coarse spatiotemporal resolution and less detailed representations of hail. This study instead uses an event-level pseudo–global warming (PGW) approach to simulate seven different hailstorms in their historical environments, and again in five different end-of-century PGW environments obtained from the worst-case scenario increases in CO2 of five different CMIP5 members. Changes in large-scale environmental parameters were generally found to be consistent with prior studies, showing mostly increases in CAPE, CIN, and precipitable water, with minor changes in vertical wind shear. Nearly all simulated events had moderately stronger updrafts in the PGW environments. Only cold-season events showed an increase in hail sizes both within the storms and at the surface, whereas warm-season events exhibited a decrease in hail sizes at the surface and aloft. Changes in the event-total hailfall area at the ground also showed a seasonal trend, with increases in cold-season events and decreases in warm-season events. Melting depths increased for all PGW environments, and these increases likely contributed to greater rainfall area for warm-season events, where an increase in smaller hail aloft would be more prone to melting. The differences in PGW simulation hail sizes in cold-season and warm-season events found here are likely related to differences in microphysical processes and warrant future study.

Significance Statement
It is uncertain how severe thunderstorm hazards (such as hail, tornadoes, and damaging winds) may change due to human-induced climate change. Given the significant societal risk these hazards pose, this study seeks to better understand how hailstorms may change in the future. Simulated end-of-century storms in winter months showed larger hail sizes and a larger area of event-total hailfall than in the historical simulations, whereas simulated future storms in spring and summer months showed smaller hail sizes and a reduction in the area where hail fell. An analysis of traditional environmental and storm-scale properties did not reveal a clear distinction between cold-season and warm-season hailstorms, suggesting that changes in small-scale precipitation processes may be responsible.
Self-care Behavior Based on Integrated Behavioral Model in Patients With Atrial Fibrillation: A Structural Equation Modeling Approach
Authors: Song Juhyun , Shin Seung Yong , Kim Kyunghee , Son Youn-Jung , Kim Jisu , Jang Insil 
Published: December 2023

Background: There is limited research exploring the behavioral intentions, beliefs, and application of theoretical models in relation to self-care in patients with atrial fibrillation (AF). Objective: This study aimed to identify the factors that influence self-care behavior in patients with AF. Methods: The study used an integrated behavioral model and collected data from 216 patients diagnosed with AF. Data were analyzed using SPSS 24.0 and AMOS/WIN 24.0 to verify the fit of the hypothesis model, confirm factor analysis, and the validity of the hypothesis itself. Results: Self-care behavioral intention (β = 0.433, p < .001) and habit (β = 0.395, p = .005) had a significant direct effect, while instrumental attitude (β = 0.077, p = .045), injunctive norm (β = 0.084, p = .037), and self-efficacy (β = 0.249, p = .011) had a significant indirect effect on self-care behavior, explaining 64.4% of the variance. Conclusion: The final model validated the factors that impact self-care behavior in patients with AF, highlighting the importance of fostering positive recognition of instrumental attitude, bolstering social influence and self-efficacy through significant individuals to improve self-care behavior. It is recommended to create an intervention program that encourages intentions and motivations for self-care behavior and incorporates tactics to make self-care behavior a habit. The study’s path diagram can serve as a conceptual framework for designing strategies to enhance self-care behavior in patients with AF.
Factors associated with the presence of fear of contagion and burnout syndrome in nursing personnel during the COVID-19 pandemic
Authors: Jiménez Padilla Eduardo Amaranto , Galindo Vázquez Oscar , Jiménez Flores Juan , Costas Muñiz Rosario , Meneses García Abelardo 
Published: December 2023

Introduction: During the COVID-19 pandemic, nursing personnel presented a higher prevalence of fear of contagion, anxiety symptoms, depression, and burnout syndrome. However, the variables associated with these conditions in Mexico are unknown. Objective: To determine the clinical, sociodemographic, and psychological variables associated with fear of contracting COVID-19 and burnout syndrome in nursing personnel. Methods: The study was a cross-sectional correlational study. It included 423 Mexican nursing professionals, working in public and private institutions, of different specialties aged 18–61 years ( M = 36 years), the sampling was non-probabilistic by convenience. The instruments used were: COVID-19 fear scale, Maslach Burnout Inventory, Generalized Anxiety Disorder Scale-7 and Patient Health Questionnaire-9. Multinomial logistic regression models were used to analyse the results. Results: The factors associated with fear of contagion were anxiety symptoms (Odds Ratio [OR]: 7.806, p < 0.05), caring for patients with COVID-19 (OR: 5.460, p < 0.05, 0.001) and mild emotional exhaustion (OR: 5.181, p < 0.05). The syndrome dimensions were: depressive symptoms (OR: 12.062; 7.667, p < 0.05), fear of contagion (OR: 4.978; 4.913; 4.921; 4.921, p < 0.01), marital status (OR: 3.404; 3.219, p < 0.05) and young age (OR: 1.064; 1.084, p < 0.05). Conclusions: The factors associated with fear of contagion and burnout syndrome found were having clinical psychological symptoms, as well as being young, being single, being married and being in the health system caring for patients with COVID-19.
Patient-reported function, quality of life and prosthesis wear in adults born with one hand: a national cohort study
Authors: Sletten Ida Neergård , Klungsøyr Kari , Garratt Andrew , Jokihaara Jarkko 
Published: December 2023

We invited individuals aged above 16 years with a congenital transverse reduction deficiency at and above the wrist born in Norway between 1970 and 2006 to complete the short version of the Disabilities of the Arm, Shoulder and Hand Outcome Measure, the 5-Level EuroQoL-5-Dimension instrument, the RAND 36-Item Short Form Health Survey and a single-item questionnaire on arm function, appearance, pain and prosthesis wear. Of 154 eligible participants, 58 (38%) responded. Their scores were not different from the general population. All had been offered prostheses, and 56 (97%) had been fitted at a median age of 1 year (interquartile range 0–2.8). Of the participants, 37 (64%) were still prosthesis wearers, while 21 (36%) were non-wearers or using gripping devices only. Prosthesis wearers had higher levels of ‘vitality’ as assessed by the RAND-36 and rated their arm appearance higher, but there were no other score differences, indicating that prosthesis rejection is not associated with worse functional outcomes. Level of evidence: III
Treatment of Dynamic Claw Toe Deformity Through Lengthening of the Flexor Tendons of the Hallux and Toes at the Midfoot Level
Authors: Mansur Henrique , Lucas Phelipe Pinheiro Alves , Maranho Daniel Augusto 
Published: December 2023

The claw toe deformity is characterized by the flexion of interphalangeal joints (IPJs) with hyperextension of the metatarsophalangeal (MTP) joint. It can be flexible and reducible or rigid and irreducible, or dynamic. The most common cause of dynamic claw toes is a neurological disorder, like sequelae of an ischemic contracture of the muscle belly after a compartment syndrome. Most of the surgical techniques require multiple procedures and may be associated with complications such as toe stiffness, persisting metatarsalgia, and toe malalignment. The aim of this study is to present an option for the surgical treatment of the dynamic claw toe deformity, by simultaneous tenodesis and lengthening of the flexor hallucis longus (FHL) and flexor digitorum longus (FDL) tendons at Henry’s knot through a single midfoot incision. Levels of Evidence: V; Therapeutic Study; Expert Opinion
One-pot, degradable, silica nanocarriers with encapsulated oligonucleotides for mitochondrial specific targeting
Authors: Trayford Chloe , Wilhalm Alissa , Habibovic Pamela , Smeets Hubert , van Tienen Florence , van Rijt Sabine 
Published: December 2023

AbstractMutations in nuclear and mitochondrial genes are responsible for severe chronic disorders such as mitochondrial myopathies. Gene therapy using antisense oligonucleotides is a promising strategy to treat mitochondrial DNA (mtDNA) diseases by blocking the replication of the mutated mtDNA. However, transport vehicles are needed for intracellular, mitochondria-specific transport of oligonucleotides. Nanoparticle (NP) based vectors such as large pore mesoporous silica nanoparticles (LP) often rely on surface complexation of oligonucleotides exposing them to nucleases and limiting mitochondria targeting and controlled release ability. In this work, stable, fluorescent, hollow silica nanoparticles (HSN) that encapsulate and protect oligonucleotides in the hollow core were synthesized by a facile one-pot procedure. Both rhodamine B isothiocyanate and bis[3-(triethoxysilyl)propyl]tetrasulfide were incorporated in the HSN matrix by co-condensation to enable cell tracing, intracellular-specific degradation and controlled oligonucleotide release. We also synthesized LP as a benchmark to compare the oligonucleotide loading and release efficacy of our HSN. Mitochondria targeting was enabled by NP functionalization with cationic, lipophilic Triphenylphosphine (TPP) and, for the first time a fusogenic liposome based carrier, previously reported under the name MITO-Porter. HSN exhibited high oligonucleotide incorporation ratios and release dependent on intracellular degradation. Further, MITO-Porter capping of our NP enabled delayed, glutathione (GSH) responsive oligonucleotide release and mitochondria targeting at the same efficiency as TPP functionalized NP. Overall, our NP are promising vectors for anti-gene therapy of mtDNA disease as well as many other monogenic disorders worldwide.
Graphical Abstract
A rapid, non-invasive, clinical surveillance for CachExia, sarcopenia, portal hypertension, and hepatocellular carcinoma in end-stage liver disease: the ACCESS-ESLD study protocol
Authors: Nasr Patrik , Forsgren Mikael , Balkhed Wile , Jönsson Cecilia , Dahlström Nils , Simonsson Christian , Cai Shan , Cederborg Anna , Henriksson Martin , Stjernman Henrik , Rejler Martin , Sjögren Daniel , Cedersund Gunnar , Bartholomä Wolf , Rydén Ingvar , Lundberg Peter , Kechagias Stergios , Leinhard Olof Dahlqvist , Ekstedt Mattias 
Published: December 2023

Abstract
Background
Liver cirrhosis, the advanced stage of many chronic liver diseases, is associated with escalated risks of liver-related complications like decompensation and hepatocellular carcinoma (HCC). Morbidity and mortality in cirrhosis patients are linked to portal hypertension, sarcopenia, and hepatocellular carcinoma. Although conventional cirrhosis management centered on treating complications, contemporary approaches prioritize preemptive measures. This study aims to formulate novel blood- and imaging-centric methodologies for monitoring liver cirrhosis patients.

Methods
In this prospective study, 150 liver cirrhosis patients will be enrolled from three Swedish liver clinics. Their conditions will be assessed through extensive blood-based markers and magnetic resonance imaging (MRI). The MRI protocol encompasses body composition profile with Muscle Assement Score, portal flow assessment, magnet resonance elastography, and a abbreviated MRI for HCC screening. Evaluation of lifestyle, muscular strength, physical performance, body composition, and quality of life will be conducted. Additionally, DNA, serum, and plasma biobanking will facilitate future investigations.

Discussion
The anticipated outcomes involve the identification and validation of non-invasive blood- and imaging-oriented biomarkers, enhancing the care paradigm for liver cirrhosis patients. Notably, the temporal evolution of these biomarkers will be crucial for understanding dynamic changes.

Trial registration
Clinicaltrials.gov, registration identifier NCT05502198. Registered on 16 August 2022. Link: https://classic.clinicaltrials.gov/ct2/show/NCT05502198.
Efficacy comparison of 7- and 14-day P-CAB based bismuth-containing quadruple regimen with PPI based bismuth-containing quadruple regimen for Helicobacter pylori infection: rationale and design of an open-label, multicenter, randomized controlled trial
Authors: Oh Chang Kyo , Lim Hyun , Seo Seung In , Lee Sang Pyo , Bang Chang Seok , Shin Woon Geon , Kim Jin Bae , Jang Hyun Joo , Baik Gwang Ho 
Published: December 2023

Abstract
Background
Owing to its strong acid inhibition, potassium-competitive acid blocker (P-CAB) based regimens for Helicobacter pylori (H. pylori) eradication are expected to offer clinical advantages over proton pump inhibitor (PPI) based regimens. This study aims to compare the efficacy and adverse effects of a 7-day and a 14-day P-CAB-based bismuth-containing quadruple regimen (PC-BMT) with those of a 14-day PPI-based bismuth-containing quadruple regimen (P-BMT) in patients with high clarithromycin resistance.

Methods
This randomized multicenter controlled clinical trial will be performed at five teaching hospitals in Korea. Patients with H. pylori infection who are naive to treatment will be randomized into one of three regimens: 7-day or 14-day PC-BMT (tegoprazan 50 mg BID, bismuth subcitrate 300 mg QID, metronidazole 500 mg TID, and tetracycline 500 mg QID) or 14-day P-BMT. The eradication rate, treatment-related adverse events, and drug compliance will be evaluated and compared among the three groups. Antibiotic resistance testing by culture will be conducted during the trial, and these data will be used to interpret the results. A total of 366 patients will be randomized to receive 7-day PC-BMT (n = 122), 14-day PC-BMT (n = 122), or 14-day P-BMT (n = 122). The H. pylori eradication rates in the PC-BMT and P-BMT groups will be compared using intention-to-treat and per-protocol analyses.

Discussion
This study will demonstrate that the 7-day or 14-day PC-BMT is well tolerated and achieve similar eradication rates to those of 14-day P-BMT. Additionally, the 7-day PC-BMT will show fewer treatment-related adverse effects and higher drug compliance, owing to its reduced treatment duration.

Trial registration
Korean Clinical Research Information Service registry, KCT0007444. Registered on 28 June 2022, https://cris.nih.go.kr/cris/index/index.do.
GRB7 plays a promoting role in the progression of gastric cancer
Authors: Zhu Guomin , Cai Hu , Xiao Qiang , Zeng Shukun , Jiang Xiaohua , Liu Donglan 
Published: December 2023

Abstract
Background
Gastric cancer is a clinically common tumor, showing an upward trend of both incidence and mortality. GRB7 has been identified as a vital regulator in tumor progression. This study aims to uncover the biological function of GRB7 in gastric cancer process.

Methods
immunohistochemical (IHC) staining using a tissue microarray (TMA), quantitative reverse transcription PCR (qRT-PCR) and Western blotting were performed to detect the expression of genes. Furthermore, gastric cancer cell lines AGS and MGC-803 were transfected with short hairpin RNAs against GRB7. The biological function of GRB7 in gastric cancer cells were examined by CCK-8, flow cytometry, wound healing and Transwell assays. Then, in vivo tumor formation assay was conducted to explore the effects of GRB7 on tumor growth. Finally, expression levels of proteins related to cell functions were determined by Western blotting. Coimmunoprecipitation (CoIP) assay was performed to assess the protein-protein interaction.

Results
GRB7 was up-regulated in gastric cancer tissues and cell lines, and its expression was inversely proportional to survival of gastric cancer patients. Moreover, GRB7 knockdown inhibited proliferative, migratory abilities, as well as promoted cell apoptosis in gastric cancer cells. Further study suggested that GRB7 silencing could suppress gastric cancer tumor growth in vivo. Furthermore, our study uncovered an important interaction between GRB7 and MyD88. Silencing MyD88 was observed to alleviate the malignant phenotypes promoted by GRB7 in gastric cancer cells.

Conclusions
Together, this study provided evidence that GRB7 may be an effective molecular targets for the treatment of gastric cancer.
Appropriate dose of regorafenib based on body weight of colorectal cancer patients: a retrospective cohort study
Authors: Nakashima Masayuki , Li Kan , Chen Qichen , de Silva Sajith , Li Hal , Kawakami Koji , Wei Qingyi , Luo Sheng , Zhao Hong 
Published: December 2023

Abstract
Purpose
Previous randomized studies have shown a survival benefit of using regorafenib but a high rate of adverse events in unresectable colorectal cancer patients. To reduce these adverse events and improve the tolerability, we examined the appropriate dose of regorafenib based on body weight.

Methods
We used a nationwide claims database in Japan and examined the efficacy and safety of regorafenib for patients with metastatic colorectal cancer between groups divided by body weight (60 kg) and median average dose (120 mg) between 2013 and 2018. We also assessed overall survival (OS) and adverse events between these groups.

Results
We identified 2530 Japanese patients (heavy weight/high dose: 513, light weight/low dose: 921, heavy weight/low dose: 452, and light weight/high dose: 644). There was no significant difference in the adverse events and OS after inverse probability treatment weighting (IPTW) adjustment between heavy weight/high dose group and light weight/low dose group (hazard ratio, HR=0.97). Among the light-weight patients, higher average dose was associated with shorter OS (IPTW adjusted HR=1.21, 95% CI 1.05 – 1.39, Table 3) while among the heavy-weight patients, there was no significant difference in OS between high and low dose groups (IPTW adjusted HR=1.14, 95% CI 0.95 – 1.37).

Conclusion
The findings suggest that a low dose of regorafenib for light-weight patients may be as safe and effective as high doses for heavy-weight patients. Further studies should be conducted to identify an appropriate dose based on each patient's physique and condition.