bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a tailored concussion education program for athletes: a pragmatic multimethods design and integrated knowledge translation approach from needs assessment to design
Authors: Black Amanda M , Turcotte Kate , Fidanova Alex , Sadler Karen , Bruin Samantha , Cheng Phoebe , Karmali Shazya , Taylor Taryn , Halliday Drew , Babul Shelina 
Published: November 2023

ObjectivesTo understand Canadian university athletic programme concussion management needs, and to describe development and content of a tailored online concussion education tool for Canadian university/college athletes.DesignAn integrated knowledge translation multiphased, multimethods approach was used. Phases included a needs assessment survey with university representatives and athletes, content selection, mapping behavioural goals to evidenced-based behaviour change techniques, script/storyboard development, engagement interviews with university athletes and tool development using user-centred design techniques.SettingCanadian U SPORTS universities (n=56).ParticipantsOverall, 64 university representatives (eg, administrators, clinicians) and 27 varsity athletes (52% male, 48% female) completed the needs assessment survey. Five athletes participated in engagement interviews.Outcome measuresSurveys assessed previous athlete concussion education, recommendations for concussion topics and tool design, concussion management challenges and interest in implementing a new course.ResultsInstitutions used a median (Med) of two (range 1–5) approaches when educating athletes about concussion. Common approaches were classroom-style education (50%), online training (41%) and informational handouts (39%). University representatives rated most important topics as: (1) what is a concussion, (2) how to recognise a concussion and (3) how to report a concussion (Medall=4.8/5). Athletes felt symptom recognition (96%) and effects on the brain (85%) were most important. The majority of athletes preferred learning via computer (81%) and preferred to learn alone (48%) versus group learning (7%). The final resource was designed to influence four behaviours: (1) report symptoms, (2) seek care, (3) encourage teammates to report symptoms and (4) support teammates through concussion recovery. Examples of behaviour change techniques included: knowledge/skills, problem-solving scenarios, verbal persuasion and social comparison. Athletes are guided through different interactions (eg, videos, flip cards, scenarios, testimonials) to maximise engagement (material review takes ~30 min).ConclusionsThe Concussion Awareness Training Tool for athletes is the first Canadian education tool designed to address the needs of Canadian university/college athletes.
Outcome of long-term biliary stenting for stones in the 2010s: beware the cholecystectomised!
Authors: Ahmed Jamal , Prakash Priyanka , Mehta Gney , Davies Tessa , Lim Yin Yin , Cross Nicholas D , Czajkowski Marek Alexander , Allison Miles Clifford 
Published: November 2023

ObjectiveEndoscopic retrograde cholangiopancreatography (ERCP) is the mainstay of management for most patients with common bile duct stones (CBDS). Duct clearance at initial ERCP may not be achieved in a third of patients, many of whom may be elderly with multiple comorbidities rendering them at potentially high risk for further procedures. We aimed to quantify the rate of biliary sequelae and mortality among a large cohort undergoing a single ERCP with sphincterotomy and stent insertion without having undergone complete ductal clearance (permanent stent insertion, PSI), and to examine factors that may predispose to adverse outcomes.Design/methodOutcomes of all ERCPs undertaken on the intact papilla between February 2010 and January 2020 were distilled to identify a cohort who had undergone PSI for initially irretrievable CBDS. These were subjected to retrospective follow-up until the development of biliary sequelae, death or survival into 2023.ResultsThere were 2175 index ERCPs for CBDS, of whom 114 met the PSI criteria. Eleven did not survive their index hospitalisation, leaving 103 for follow-up. Of these, 25 (24%) developed late biliary sequelae, 19 (18%) required at least one further ERCP and 8 (8%) died from biliary sequelae. Adverse outcomes were found to be more common among those who had undergone cholecystectomy prior to ERCP, and those with periampullary diverticula.ConclusionsLong-term biliary stenting following sphincterotomy remains a valid option for selected patients with initially irretrievable bile duct stones who could be at high risk from repeat procedures.
Immune checkpoint inhibitor rechallenge in patients who previously experienced immune-related inflammatory arthritis: a multicentre observational study
Authors: Ladouceur Alexandra , Barnetche Thomas , Mouterde Gael , Tison Alice , Bitoun Samuel , Prey Sorilla , Dutriaux Caroline , Gerard Emilie , Pham-Ledard Anne , Beylot-Barry Marie , Zysman Maeva , Veillon Rémi , Domblides Charlotte , Daste Amaury , Gross-Goupil Marine , Sionneau Baptiste , Lefort Felix , Larroquette Mathieu , Richez Christophe , Truchetet Marie-Elise , Schaeverbeke Thierry , Kostine Marie 
Published: November 2023

ObjectiveAnother course of immune checkpoint inhibitors (ICIs) is often considered in patients with cancer progression and previous immune-related adverse events, including inflammatory arthritis (ICI-IA), but there are limited data regarding safety of ICI rechallenge in this setting. We aimed to assess the rate and clinical features associated with ICI-IA flare/recurrence on ICI rechallenge.MethodsWe conducted a multicentre observational study including cancer patients with ICI-IA who started a second course of ICI more than 3 months after ICI discontinuation in four French university hospitals. Primary outcome was the frequency of ICI flare/recurrence after ICI rechallenge.ResultsTwenty-three patients were included. At the time of ICI rechallenge, 18 patients reported no symptoms of ICI-IA (78%) and 5 had grade 1 (22%), 11 patients (48%) were not receiving any ICI-IA treatment, 11 (48%) were still on prednisone, 2 (9%) were on conventional synthetic disease-modifying antirheumatic drugs and 1 (4%) on anti-IL-6. ICI-IA flare/recurrence occurred in 12 patients (52%) with a median time of 1 month after ICI rechallenge. ICI-IA phenotype, disease activity and ICI-IA treatment at the time of ICI rechallenge did not differ according to ICI-IA flare/recurrence status.ConclusionIn this first observational study of ICI-IA patients rechallenged with ICI, about half of the patients experienced ICI-IA flare/recurrence with a similar phenotype but occurring earlier than the initial ICI-IA, warranting close monitoring during the first month of retreatment. Risk of flare did not differ according to baseline immunosuppressive treatment at the time of rechallenge.
PATHOLOGICAL HUMERAL FRACTURE FROM BONE METASTASIS OF A GASTROINTESTINAL STROMAL TUMOR: FIRST REPORTED CASE
Authors: Tam Johnson Pok-Him , Leung Anderson Siu-Ming 
Published: November 2023

Background: Gastrointestinal stromal tumor (GIST) is the most prevalent mesenchymal tumor of the GI tract. Metastases commonly occur in the liver and peritoneum, with very rare reported cases of bone metastases, hence, no therapeutic standard has been established for the management of bone metastases. Modern targeted therapy has improved patient survival, and although there are only a small number of reported GIST bone metastases, the incidence will likely continue to increase. Further understanding of GIST bone metastases is required for the implementation of an accurate and effective treatment plan. Case presentation: We report a 56-year-old patient who has a history of bleeding duodenal GIST resected with a Whipple operation. Post-operatively, Imatinib was started, but she developed liver metastasis 6 years later, requiring segmentectomy. She reported pain over the left humerus 2.5 years later and sustained a trivial injury to the left arm, resulting in a distal humerus shaft spiral fracture associated with a radial nerve palsy (Holstein-Lewis injury). Images showed a lytic lesion with cortical erosion and soft tissue extension at the fracture site. Biopsy confirmed GIST bone metastases. She underwent an open reduction and internal fixation with plating and curettage of the lytic lesion and made a good functional recovery afterward. Conclusion: This is the first reported case of a GIST bone metastases pathological Holstein–Lewis fracture. It highlights the potential for bone metastasis to present a long time after the diagnosis of a GIST. Although bone metastases are rare, they are now increasing due to the prolonged survival of patients and the introduction of targeted therapy. It is important to conduct long-term surveillance in specific patient demographics and future studies should be carried out to facilitate the development of a surveillance protocol in patients with GIST.
Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma
Authors: Mouhieddine Tarek H. , Nzerem Chidimma , Redd Robert , Dunford Andrew , Leventhal Matthew , Sklavenitis-Pistofidis Romanos , Tahri Sabrin , El-Khoury Habib , Steensma David P. , Ebert Benjamin L. , Soiffer Robert J. , Keats Jonathan J. , Mehr Shaadi , Auclair Daniel , Ghobrial Irene M. , Sperling Adam S. , Stewart Chip , Getz Gad 
Published: November 2023

Abstract

Clonal hematopoiesis (CH) at time of autologous stem cell transplant (ASCT) has been shown to be associated with decreased overall survival (OS) and progression-free survival (PFS) in patients with multiple myeloma not receiving immunomodulatory drugs (IMiD). However, the significance of CH in newly diagnosed patients, including transplant ineligible patients, and its effect on clonal evolution during multiple myeloma therapy in the era of novel agents, has not been well studied. Using our new algorithm to differentiate tumor and germline mutations from CH, we detected CH in approximately 10% of 986 patients with multiple myeloma from the Clinical Outcomes in MM to Personal Assessment of Genetic Profile (CoMMpass) cohort (40/529 transplanted and 59/457 non-transplanted patients). CH was associated with increased age, risk of recurrent bacterial infections and cardiovascular disease. CH at time of multiple myeloma diagnosis was not associated with inferior OS or PFS regardless of undergoing ASCT, and all patients benefited from IMiD-based therapies, irrespective of the presence of CH. Serial sampling of 52 patients revealed the emergence of CH over a median of 3 years of treatment, increasing its prevalence to 25%, mostly with DNMT3A mutations.

Significance:
Using our algorithm to differentiate tumor and germline mutations from CH mutations, we detected CH in approximately 10% of patients with newly diagnosed myeloma, including both transplant eligible and ineligible patients. Receiving IMiDs improved outcomes irrespective of CH status, but the prevalence of CH significantly rose throughout myeloma-directed therapy.
Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer
Authors: Malhi Vikram , Agarwal Priya , Gates Mary R. , Liu Lichuan , Wang Jianshuang , De Bruyn Tom , Lam Scott , Eng-Wong Jennifer , Perez-Moreno Pablo , Chen Ya-Chi , Yu Jiajie 
Published: November 2023

Abstract

Purpose:
We describe the clinical pharmacology characterization of giredestrant in a first-in-human study.

Experimental Design:
This phase Ia/Ib dose-escalation/-expansion study (NCT03332797) evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of giredestrant in estrogen receptor–positive HER2-negative locally advanced/metastatic breast cancer. The single-agent dose-escalation stage evaluated giredestrant 10, 30, 90, or 250 mg once daily. The dose-expansion stage evaluated single-agent giredestrant at 30, 100, and 250 mg once daily. Dose-escalation and -expansion phases also evaluated giredestrant 100 mg combined with palbociclib 125 mg.

Results:
Following single-dose oral administration, giredestrant was rapidly absorbed and generally showed a dose-proportional increase in exposure at doses ranging from 10 to 250 mg. At the 30 mg clinical dose, maximum plasma concentration was 266 ng/mL (50.1%) and area under the concentration–time curve from 0 to 24 hours at steady state was 4,320 ng·hour/mL (59.4%). Minimal giredestrant concentrations were detected in urine, indicating that renal excretion is unlikely to be a major elimination route for giredestrant. Mean concentration of 4beta-hydroxycholesterol showed no apparent increase over time at both the clinical dose (30 mg) and a supratherapeutic dose (90 mg), suggesting that giredestrant may have low CYP3A induction potential in humans. No clinically relevant drug–drug interaction was observed between giredestrant and palbociclib. Giredestrant exposure was not affected by food and was generally consistent between White and Asian patients.

Conclusions:
This study illustrates how the integration of clinical pharmacology considerations into early-phase clinical trials can inform the design of pivotal studies and accelerate oncology drug development.

Significance:
This work illustrates how comprehensive clinical pharmacology characterization can be integrated into first-in-human studies in oncology. It also demonstrates the value of understanding clinical pharmacology attributes to inform eligibility, concomitant medications, and combination dosing and to directly influence late-stage trial design and accelerate development.
Introduction to “Revolutionary Painting and the Palestinian Revolution,” by Mohammed Chabâa, and “Palestinian Artists and the Biennial,” from Toni Maraini's “Baghdad 1974: A Summary of the First Arab Biennial of Fine Arts” (Both 1974)
Authors: Amin Alessandra 
Published: November 2023

Abstract
In 1974, Moroccan cultural journal Intégral published a special edition on the first Arab biennial of visual arts, which had just taken place in Baghdad. The two documents translated here come from this special edition, and both of them deal with the Palestinian presence at the landmark exhibition. Moroccan artist Mohamad Chebaa and Italian-Moroccan art historian Toni Maraini each consider Palestine an ideal arena for the development of decolonial “combat art,” but express disappointment with its pavilion's emphasis on folk idioms over images of armed struggle. The introduction to these documents situates them in relation to Moroccan and Palestinian discourses surrounding heritage and colonialism, arguing that the Palestinian context erodes the distinction between “folk” and “combat” art in ways foreign to the Casablanca-based intellectuals.
Decriminalisation of Adultery in Taiwan
Authors: Huang David KC , Li Nigel NT 
Published: November 2023

Abstract
This article examines Taiwan’s decriminalisation of adultery in the landmark decision of Judicial Yuan Interpretation No. 791 [2020]. The Justices affirmed the right to freedom of sexual behaviour, ruling that imposing a criminal limit on the right in the name of marriage protection or the public interest is a disproportionate means to protect marriage, because the law cannot protect marriage. Moreover, a proviso of the law of adultery was held to be incompatible with the principle of equality, as it allowed the faithful spouse to sue only the person who fornicated with the unfaithful spouse, which was a vestige of moral vengeance rooted in the Chinese culture of nulla poena sine ‘Li’ (Chu-Li-Ru-Xing).
Effects of single and multiple bouts of eccentric exercise on immune responses to HSV-gD1 DNA vaccination in mice
Authors: Molanouri Shamsi M. , Soudi S. , Afshounpour M.T. , Jamali A. , Soleimanjahi H. , Quinn L.S. , Gharakhanlou R. , Karimi H. 
Published: November 2023

Abstract
DNA vaccines comprise one modality of novel vaccination techniques. DNA vaccines employ intramuscular injection of DNA that codes for specific antigens from a pathogen. Prolonged eccentric endurance exercise can stimulate immune responses, possibly by increasing inflammatory mediators. This study aimed to determine the effects of one or three sessions of downhill running on the effectiveness of Herpes simplex virus type I glycoprotein D (HSV-gD1) DNA vaccination. Mice without or with one and three sessions of downhill running were vaccinated intramuscularly with the DNA vaccine or the empty vector. Cellular immune responses were assessed using an in vitro assay of lymphocyte proliferation in response to recall antigens. Also, a virus neutralisation test was used to determine the levels of neutralising antibodies in serum samples. In addition, Th1 and Th2 immune responses, and the ratio of the Th1/Th2 is considered an indicator of immune responses to infection in the current study. Multiple bouts of downhill running increased humoral immune responses after immunisation, also although Th2 immune responses decreased, lymphocyte proliferation and Th1/Th2 ratio immune responses increased following the viral challenge compared to the other groups. In addition, the timing of the 3-session exercise regimen plus DNA vaccination immediately following the last exercise session, as opposed to DNA vaccination 48 h before a single session of exercise, may account for the greater efficacy of DNA vaccination in the multiple bouts of the intensive exercise group. These findings indicate that short-term repeated bouts of eccentric endurance exercise have increased immune responses to intramuscular DNA-based vaccines.
Effect of cleaning, milling, and cooking on the reduction of deoxynivalenol in freshly harvested rice
Authors: Chen X.X. , Wu D.L. , Wu X.L. , Mokoena M.P. , Olaniran A.O. , Shi J.R. , Xu J.H. , Dong F. 
Published: November 2023

Abstract
Fusarium mycotoxins were frequently present in freshly harvested rice samples caused by Fusarium head blight in China recently. Due to the importance of rice and the risks associated with mycotoxins, the fate of Fusarium mycotoxins in rice was evaluated by physical methods. In the present study, a total of 157 freshly harvested rice samples were collected from fields in Jiangsu Province. Mycotoxin analysis showed that only Fusarium mycotoxins were found in these samples, with deoxynivalenol (DON) being the major mycotoxin. Twenty-three freshly harvested rice samples containing concentrations of DON higher than 200 μg/kg were selected for cleaning and milling. Compared with air or gravity separation, the combined air and gravity separation was the most effective cleaning method to decrease the content of DON. After milling, brown and white rice intended for human consumption presented lower level of DON than freshly harvested rice, husks, and bran. Three types of brown and white rice with different contents of DON were chosen for cooking. Compared with other treatments, preboiled was the most effective method to reduce DON in both brown and white rice. The results of this study improve our understanding of the transfer ratios of DON and the development of effective control measures during the postharvest stage.
An investigation of different antimycotoxin additives in swine intestinal explants challenged with aflatoxin and fumonisin: ex vivo and in vitro models
Authors: Alves Sarturi J. , Tonial Simões C. , Rosa da Silva C. , Fabris Laber I. , de Lima Schlösser L.M. , Sturza D.F. , Mallmann C.A. 
Published: November 2023

Abstract
This study aimed to develop an ex vivo model to evaluate the efficacy of antimycotoxin additives (AMAs) against aflatoxin B1 (AFB1) and fumonisin B1 (FB1) using intestinal explants of growing pigs. Four assays of two treatments with 12 replicates each (24 jejunal explants used per assay) were performed using an Ussing Chamber (UC) system: two assays to evaluate two AMAs for AFB1 and two assays to evaluate two AMAs for FB1. The difference between the two assays for both AFB1 and FB1 was the composition of the additive used. The treatments for AFB1 assays were control [Buffer solution (BS) + 1 mg/l AFB1] and AMA (BS + 1 mg/l AFB1 + 0.5% AMA 1 or 2). The treatments for FB1 assays were control (BS + 50 mg/l FB1) and AMA (BS + 50 mg/l FB1 + 0.5% AMA 3 or 4). The efficacy of the four additives was also tested in vitro. The AFB1 concentrations in the explants from AMAs 1 and 2 were lower () than in the control. AMAs 1 and 2 reduced the jejunal absorption of AFB1 by 83.4 and 72.9%, respectively. Explants from AMAs 3 and 4 had lower FB1 () concentration when compared to the respective control treatment. AMAs 3 and 4 reduced the FB1 absorption by 31.9 and 17.6%, respectively. In the in vitro test, AMAs 1 and 2 provided 98.4 and 86.3% of AFB1 adsorption, respectively, while AMA 3 and 4 provided 91.2 and 80.5% FB1 adsorption, respectively. The ex vivo model can be a useful tool in evaluating the effectiveness of antimycotoxin additives for AFB1 and FB1 in swine. However, the low FB1 uptake in jejunal explants highlights the need for the development of additional information to improve the method.
Environmental conditions influencing growth and development of the black soldier fly (Hermetia illucens (L.)) (Diptera: Stratiomyidae)
Authors: Cammack J.A. , Tomberlin J.K. 
Published: November 2023

Abstract
While biotic conditions are recognised contributors to the growth and production of the black soldier fly, Hermetia illucens (L.) (Diptera: Stratiomyidae), abiotic conditions are arguably of equal or greater relevance. Shifts in key environmental conditions can be the difference between optimal production of a black soldier colony, or its collapse. As with all insects, the impact of these criteria is highly dependent on development stage of the insect and scale of application (e.g. growth chamber in a laboratory versus an industrial rearing room). Through the analysis presented herein, the impact of three abiotic factors (temperature, humidity, and photophase) on immature black soldier flies will be discussed as a means to serve as a model for investigating other abiotic factors contributing to the physiology of the species. By identifying the impact of these factors on black soldier fly development, the industry can optimise production, minimise financial investment, and enhance the economic and environmental returns of the system.