bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets
Authors: Dalba Paul A. , Kane Stephen R. , Isaacson Howard , Fulton Benjamin , Howard Andrew W. , Schwieterman Edward W. , Thorngren Daniel P. , Fortney Jonathan , Vowell Noah , Beard Corey , Blunt Sarah , Brinkman Casey L. , Chontos Ashley , Dai Fei , Giacalone Steven , Hill Michelle L. , Kosiarek Molly , Lubin Jack , Mayo Andrew W. , Močnik Teo , Akana Murphy Joseph M. , Petigura Erik A. , Rice Malena , Rubenzahl Ryan A. , Van Zandt Judah , Weiss Lauren M. , Dragomir Diana , Kipping David , Payne Matthew J. , Roy Arpita , Teachey Alex , Villanueva Steven 
Published: February 2024

Abstract
Discovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines. Nonetheless, a sample of giant exoplanets on orbits longer than 100 days has been identified by transit hunting missions. We present long-term Doppler spectroscopy for 11 such systems with observation baselines spanning a few years to a decade. We model these radial velocity observations jointly with transit photometry to provide initial characterizations of these objects and the systems in which they exist. Specifically, we make new precise mass measurements for four long-period giant exoplanets (Kepler-111 c, Kepler-553 c, Kepler-849 b, and PH-2 b), we place new upper limits on mass for four others (Kepler-421 b, KOI-1431.01, Kepler-1513 b, and Kepler-952 b), and we show that several confirmed planets are in fact not planetary at all. We present these findings to complement similar efforts focused on closer-in short-period giant planets, and with the hope of inspiring future dedicated studies of cool giant exoplanets.
Extraskeletal Mesenchymal Chondrosarcoma of Central Nervous System – A Rare but Aggressive Tumor
Authors: Chatterjee Debajyoti , Radotra Bishan D , Madan Renu , Gupta Sunil K 
Published: February 2024

Background:
Extraskeletal mesenchymal chondrosarcoma (MCS) of the central nervous system (CNS) is extremely rare. Herein, we present the clinicopathological features of five CNS extraskeletal MCS.

Material and Methods:
Over the past 10 years, five cases of CNS MCS have been retrieved from in the archives of histopathology department. All biopsies were stained with vimentin, S-100, CD99, desmin, GFAP, INI1, WT1, STAT6, and EMA.

Results:
There were four males and one female patient in the age group of 1.5–35 years. The clinical and radiological impression was meningioma in three cases, glomus jugulare and primitive neuroectodermal tumor in one case each. All showed classic biphasic morphology, areas of undifferentiated small blue round cells sharply demarcated from the island of cartilage. Three patients experienced multiple recurrences and died subsequently.

Conclusion:
Extraskeletal MCS of CNS is rare and favors children and young adults. They show aggressive behavior and tend to recur despite surgery and radiotherapy.
Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway
Authors: Mary S. Jeslin , Veeravarmal Veeran , Thankappan Prasanth , Arumugam Paramasivam , Augustine Percy Ida , Franklin R. 
Published: February 2024

Background:
Oral cancer remains one of the most dreadful diseases in developing nations. Currently, there has been a rise in the prevalence of tongue squamous cell carcinoma (SCC), with a poor prognosis. The use of standard treatment approaches against oral cancer patients brings about several side effects. In recent years, nanomedicine has provided a versatile platform for developing new targeted therapeutic modalities. However, safety remains a concern in the synthesis of nanoparticles (NPs). Therefore, the present study aims to synthesize safer phytoconstituent-mediated gold NPs (AuNPs) utilizing leaf extracts of Annona
muricata, where the biochemical components of the plant leaf act as the reducing and capping agents in the synthesis of NPs, and to evaluate its anti-cancer activity against SCC.

Materials and Methods:
In this in vitro experimental study, AuNPs were synthesized through an effective, simple, and ecologically sound green synthesis method. After characterization of these synthesized AuNPs, in vitro assays such as 3-(4, 5-dimethylthiazole2-yl)-2, 5-biphenyl tetrazolium bromide, wound healing, and clonogenic assays were carried out to investigate the anti-cancer potential of green synthesized AuNPs in the human tongue SCC cell line (SCC-15), and the possible mechanism of action was evaluated through gene and protein expression analysis of Bax, Bcl-2, and p53 genes. The results were expressed as mean ± standard deviation using Statistical Package for Social Sciences (SPSS) 20.0 software and Student's t-test was performed for experimental data. P ≤0.05 were considered statistically significant.

Results:
The in vitro assays demonstrated that the synthesized AuNPs are exhibiting anti-cancer activity by apoptosis of SCC-15 cells in a dose-dependent manner. Further, it also revealed a highly significant decrease in anti-apoptotic Bcl-2 gene expression, whereas pro-apoptotic genes p53 and Bax revealed a highly significant increase, which is statistically significant compared to the control (P < 0.05).

Conclusion:
Our findings demonstrated that the AuNPs synthesized from A.
muricata leaf extract could act as a novel anticancer agent, particularly against SCC, after further scrutiny.
Schwannoma-like pleomorphic adenoma: A pathological quandary
Authors: Gautam Rashmi , Tomar Reena , Rana Deepika , Khurana Nita , Singh Ishwar 
Published: February 2024

ABSTRACT
Pleomorphic adenoma usually presents as a painless growing mass in locations of the salivary glands and is notorious for local recurrence if previous surgical resection is incomplete. Schwannoma is a benign peripheral nerve tumor with microscopic features of sheets of spindle-shaped cells with nuclear palisading. However, when a pathologist encounters a salivary gland tumor with microscopic morphological features of biphasic components with areas of schwannoma-like morphology, it is crucial to make a prudent diagnosis by differentiating Schwannoma-like pleomorphic adenoma and its differential diagnosis as they have remarkably different outcome in patients. We herein present a case of Schwannoma-like pleomorphic adenoma and discuss its approach to diagnosis and literature search.
A Multi-centric retrospective study into the epidemiological distribution of breast cancer patients in India
Authors: Reddy Vijay Anand , Sarin Ramesh , Panda Dipanjan , Hanitha RNM , Jain Jugnu , Chatterjee Soma , Annapurneswari S , Saipillai Mohamed Zehran , Gupta Shaikat , Khan Enamuddin , Bhattacharya Jibak , Bhandari Trilok Prasad Singh , Prasad S. V. S. S. , Swain Meenakshi 
Published: February 2024

ABSTRACT

Background:
A multicentric private hospital-based retrospective study was conducted to understand the epidemiology of breast cancer in terms of demographics and clinical characteristics (staging and hormone receptor status) at the time of diagnosis.

Methods:
The data for 5,688 female breast cancer patients were collected from the hospital and clinical records of four study centres. All statistical analysis was performed using Microsoft Excel 2016 and R software. Survival was estimated by the Kaplan-Meier method and compared by the log-rank test. A P value of <.05 was considered statistically significant.

Results:
The mean and median age of the study population was 52.6 (± 12.4) years and 53.0 (range 51-54 across the four centers) years, respectively. About 68% of patients were in the age category of 41 65 years, 17.6% were <40 years old among whom 23.4% of patients reported a positive family history. Most of the patients (66.3%) were diagnosed at an early stage (Stage I and II). The 3-year OS probability was 100%, 97.5%, 94.1%, and 74.7% for TNM Stages I, II, III, and IV, respectively. The 3-year RFS was 95.7%, 95.5%, 84.5%, and 49% for TNM Stages I, II, III, and IV, respectively.

Conclusion:
The present study highlights the epidemiological distribution of breast cancer patients. It emphasizes the importance of disease awareness among the urban and educated female population as most patients were diagnosed at earlier stages and demonstrated higher OS and RFS than reported in government registries.
Pretreament neutrophil-lymphocyte ratio (NLR): A felicitous prognostic marker in carcinoma lung
Authors: Sehgal Shailley A. , Malik Garima , Sachdeva Aman , Chauhan Ashok K. , Kaushal Vivek , Kaur Paramjeet , Atri Rajeev 
Published: February 2024

ABSTRACTS

Background:
Mechanics of inflammation and oncogenesis are intertwined with each other. Thus, the role of inflammatory markers like neutrophil-lymphocyte ratio (NLR) as a foreteller of lung carcinoma is retrospectively appraised in this study.

Material and Methods:
Retrospective assessment of hospital records of carcinoma lung patients was done between January 2018 and January 2020 and pretreatment NLR was calculated. Median NLR was taken as cut off and thereafter correlation was studied between pretreatment NLR and overall survival, using Kaplan-Meier survival analysis. Cox regression analysis was applied to identify factors affecting survival.

Results:
Study population included 135 eligible patients with median age of 60 years and male to female ratio of 8.6:1. 47.41% patients were of stage III and 52.59% patients belonged to stage IV. The duration of follow-up ranged between 0.5 and 22 months. Median NLR was 3.1 (range, 0.90–11.25) and median overall survival in patients with NLR <3.1 and ≥3.1 was 6 months versus 3 months, respectively (P-value = 0.001). NLR value in nonsmall cell and small cell lung cancer was analyzed separately and showed significant variation in median survival in nonsmall cell lung cancer patients only (P-value = 0.001).

Conclusions:
Study results summarized that pretreatment NLR can be taken as a cheap and easily available predictor of prognosis in carcinoma lung cases and more so in nonsmall cell lung carcinoma cases. Large prospective trials are warranted to further potentiate this fact.
Global and promoter specific hypermethylation of tumor suppressor genes P16, SOCS1, and SHP1 in oral squamous cell carcinoma and oral submucous fibrosis
Authors: Ukey Shweta , Jain Ankit , Dwivedi Shailendra , Vishnoi Jeewan Ram , Chugh Ankita , Purohit Purvi , Pareek Puneet , Elhence Poonam , Misra Sanjeev , Sharma Praveen 
Published: February 2024

ABSTRACTS
Aberrant methylation pattern leads to altered gene expression, that is, involved in the transformation of various cancers, including oral squamous cell carcinoma (OSCC). In the present study, an attempt has been made to examine the association of global and promoter-specific methylation of tumor suppressor genes in patients with OSCC and oral submucous fibrosis (OSMF). Promoter-specific methylation of tumor suppressor genes P16, SOCS1, and SHP1 had been studied earlier for their aberrant methylation patterns in other cancers; however, these studies were mainly conducted in-vitro or in animal models, and as such, only a few studies are available on human samples. In the present study evaluation of promoter-specific methylation of genes P16, SOCS1, and SHP1 in 76 patients’ blood and tissue samples was done and compared with methylation of 35 healthy control samples using qPCR. Further, these samples were analyzed for global methylation patterns using ELISA. The results have shown a significant decreasing trend of promoter methylation (OSCC > OSMF > Controls); the methylation indices (MI) were significantly higher in OSCC than in the controls. The median MI of three genes for OSCC were P16MI (0.96), SHP1MI (0.79), and SOCS1 (0.80). Similarly, median MIs for OSMF were P16MI (0.18), SHP1 MI (0.19), and SOCS1 MI (0.5) against controls with MI (0) for each of the three genes. The global methylation %mC values were 1.9, 0.5, and 0.1, respectively. The values of MI and %mC were found to correlate with various risk factors such as tobacco, smoking, and alcohol consumption, which are positively involved in OSMF pathogenesis followed by oral cancer progression. Further, the methylation trend in tissue was reflected in blood samples, proving a window for methylation load to be used as a lesser invasive biomarker. The sensitivity and specificity of methylation load were also found reasonable. Therefore, the current study suggests that there may be a role of global and promoter-specific methylation load in the transition of OSMF to OSCC.
Factors associated with knowledge of health care workers toward COVID-19 in health facilities West Guji zone, Southern Ethiopia, 2020
Authors: Wayessa Zelalem Jabessa , Wako Wako Golicha 
Published: February 2024

BACKGROUND:
Coronavirus pandemic puts healthcare workers (HCWs) at high risk and challenges the abilities of healthcare systems to respond to the crisis. This study aimed to assess the level of knowledge of HCWs and associated factors in West Guji zone public health facilities in southern Ethiopia.

MATERIALS AND METHODS:
A health facility-based quantitative cross-sectional study was undertaken from June 10 to July 10, 2020. Two hundred and eighty-three HCWs were involved in the study using a systematic sampling method. The instrument was pretested on 5% of the sample in Yabello Hospital. Data were analyzed using bivariate and multivariate logistic regression.

RESULTS:
The HCW who had good knowledge was 84.7%. HCWs who had degree holders, masters and above holders, work experience of 2–4 years, and >4 years of experiences, had training on Coronavirus, and medical diseases were significantly associated with good knowledge of Coronavirus.

CONCLUSIONS:
This study indicated that HCWs’ knowledge about the Coronavirus was good. Improving the educational status of HCWs and giving updated training on the Coronavirus will improve HCW's knowledge of the Coronavirus.
Smartphone usage and addiction among undergraduate dental students in Malaysia
Authors: Arora Ankita , Wong Wan Wen , Yee Ng See , Lee Rui Yin , Soe Htoo Htoo Kyaw 
Published: February 2024

BACKGROUND:
Behavioral addiction to smartphones is a common phenomenon in the present digital age, wherein indulgence in these devices is compulsive and impacts physical, social, and psychological health of the population. The smartphones effect on a dental student's life is detrimental to their academics, health, and efficiency in providing clinical patient care. To assess use and addiction of smartphones among dental students under six major domains and to compare this based on their gender, ethnicity, and year of study.

MATERIALS AND METHODS:
A cross-sectional study using a validated questionnaire, Smartphone addiction scale was conducted among 349 undergraduate students (N = 349) at a private dental school in Malaysia.

RESULTS:
Overall results are presented as mean scores under six domains with total score as 142.40 (33.65). The total scores compared between two genders did not show statistical difference, however on comparing individual domains, females (25.25) had higher mean score for daily life disturbance (P = 0.013) and males (30.17) for cyberspace-oriented relationship (P = 0.001). Chinese students had higher scores with respect to withdrawal (32.45) and cyberspace-oriented relationship (29.48) as compared to other ethnicities. Year 4 students show higher scores than other years in daily life disturbance (27.44), tolerance (16.81), and overuse (16.51).

CONCLUSION:
Our research presents the extent and pattern of smartphone of usage and addiction among the undergraduate students at a dental school in Malaysia. The indicators of addiction highlighted in the study are pivotal in spreading awareness regarding this overuse and addiction as well as planning further research in this area.
Effect of Commercial Probiotics on Growth Performance of Sabaki tilapia, Oreochromis spilurus
Authors: Chithambaran Sambhu , Al Harbi Mamdouh , Ali Ghurab Afnan 
Published: February 2024

The use of beneficial bacteria to improve fish health and growth is an innovative method in aquaculture practice. A study was conducted to test the efficiency of two commercial probiotics, such as Sanolife Pro-W and Protexin Balance on the microbial load in culture water and growth performance of Sabaki tilapia, Oreochromis spilurus in fiber glass tanks (400 liters) for a period of 75 days. Sanolife was supplied at 3ppm in the rearing water daily, and designated as Treatment 1. Protexin was incorporated at the rate of 1ppm in a supplementary feed, containing 35% protein in diet and considered as treatment 2. A control was also maintained without treating with probiotics in culture water or feed. Healthy and uniform size fish (3.1 ± 0.5g) were stocked at the rate of 25peaces/tank and both treatments and control tanks were set on a randomized design and triplicated. Water quality parameters (physical and chemical), microbial load in water, growth performance and body composition (nutrients) of fish were assessed during the culture period. Significant difference (p<0.01) on growth was observed between control and treatments, the highest growth was recorded in Protexin treated fish. Water quality parameters did not show significant variations. Carcass protein and lipid content showed significant difference between control and treatments. Considerable reduction in bacterial population and improved growth were observed in Sanolife Pro W treated water, when compared to Control. The result shows that Sanolife significantly reduce the bacterial population in culture water and Protexin improves the growth of fish. The outcome of the study has great application in the field of tilapia aquaculture sector in the Kingdom.
KEPEMIMPINAN, LINGKUNGAN KERJA TERHADAP STRES DAN PERFORMANSI KARYAWAN RESTORAN MENGGUNAKAN PLS
Authors: Abnur Asman , Wibowo Agung Edy , A.Nasution M.Nur 
Published: February 2024

ABSTRAKSI
Berlalunya wabah Covid-19 telah memberi ruang dan waktu bagi industri pariwisata untuk bangkit dan berkembang kembali. Dewasa ini pariwisata telah menjadi bagian dari sekian aspek yang diprioritaskan oleh beberapa negara dalam meningkatkan pendapatan sebuah negara. Pariwisata dapat diberikan pengertian sebagai aktivitas seseorang dari suatu tempat ke tempat yang berbeda dengan tujuan untuk berkunjung, singgah sementara waktu yang tidak terlalu lama dengan motif untuk menikmati lokasi kunjungan dalam wilayah tersebut. Bertumbuhnya kegiatan industry pariwisata tentu saja akan memberikan dampak bagi pertambahan laju atau peningkatan pendapatan suatu negara. Pada kenyataanya banyak negara membuktikan bahwa .sektor pariwisata mampu mendorong dan memberi efek penambahan perkapita sebuah negara dan memberikan daya dorong bagi ekonomi dan industri turunan pariwisata seperti munculnya industri kerajinan, industri dan produk cinderamata, Munculnya ragam dan bentuk model penginapan seperti homestay, guest house, dan unit unit usaha kecil menengah yang berhubungan dengan pariwisata seperti kuliner lokal, dan jajanan makanan khas daerah..
Tujuan dari studi ini adalah untuk mengetahui dan menganalisis kepemimpinan, lingkungan kerja terhadap stress kerja, dan pengaruh masing masing variabel tersebut terhadap performasi karyawan. restoran Sederhana dan Nasi Kapau yang terdapat di Kota Batam. Responden yang digunakan untuk mendukung studi ini sebanyak 117 partisipan. Hasil penelitian menunjukan bahwa kepemimpinan berpengaruh signifikan terhadap stres, lingkungan kerja berpengaruh signifikan terhadap performansi, lingkungan kerja berpengaruh signifikan terhadap stres dan stres berpengaruh signifikan terhadap performansi
Work Environment and Employee Turnover in the Insurance Industry in Kenya
Authors: Gichungu Teresia , Mukulu Elegwa , Simiyu Alice 
Published: February 2024

Purpose: The purpose of this study was to determine the influence of work environment on employee turnover in the insurance industry in Kenya.
Methodology: Descriptive explanatory research design was applied by the study. The study target population was 404 senior staff working in the 48 insurance companies in Kenya. Based on Krejcie and Morgan sample size determination formula the sample size for this study was 197 respondents. The 197 managers were chosen with the help of stratified random sampling technique. Primary and secondary data was collected where questionnaires were used to collect primary data. The study used SPSS version 25 software to analyse the data. Both descriptive and inferential analyses were carried out. Results from analysed data were presented in tables.
Results: The inferential statistics results revealed a negative significant relationship between work environment on employee turnover in the insurance industry in Kenya at p<0.05. Work environment on employee turnover in the insurance industry had a Pearson’s correlation of (r= -.769, p<0.05). Since the p-value (0.023) was less than the selected level of significance (0.05), the relationship was considered significant. This therefore suggests that work environment affects employee turnover in the insurance industry in Kenya. The R-squared for the relationship between work environment and employee turnover in the insurance industry in Kenya was 0.404; this is an indication that at 95% confidence interval, 40.4% variation in employee turnover in the insurance industry in Kenya can be attributed to changes in work environment. However, the remaining 59.6% variation in employee turnover in the insurance industry in Kenya suggests that there are other factors other than work environment that explain employee turnover in the insurance industry in Kenya.
Unique Contribution to Theory, Practice and Policy: Theory Z used in this study may be used to anchor future studies on describing how providing a job for life with a strong focus on the well-being of the employee, both on and off the job increases employee loyalty to the company. The study recommends that the management of insurance companies should always build a conducive work environment through emphasis on goals. Create a harmonious non-physical work environment and pay attention to the physical work environment of employees at work. According to the study, policy makers should formulate policies that will ensure that insurance companies build a work environment that attracts, retain and motivate its employees so that to help them work comfortable and increase organization productivity.