bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic evolution and driven path of digital economy, green technology innovation and ecological resilience: An empirical analysis based on city clusters in the middle reaches of the Yangtze River in China
Authors: Wang Linyan , Hu Haiqing , Wang Xianzhu , Zhang Xincheng , Liang Zhikang , Yan Zhishan 
Published: December 2023

Abstract

In the background of the synergistic development of digitalization and greening, how to achieve the synergistic development of digital economy, green technology innovation and ecological resilience has become an important research issue. This study combines the TOE theory to construct a theoretical framework for the synergistic development of digital economy, green technology innovation and ecological resilience. Combined with the data of 28 cities in the city cluster in the middle reaches of the Yangtze River from 2011 to 2021, the level of synergistic evolution of digital economy, green technological innovation and ecological resilience was measured by using the Haken model, and the driven path of synergistic development was analyzed with the help of fsQCA. The results of the study show that: (1) the synergistic evolution level of the city cluster in the middle reaches of the Yangtze River in the observation period has a rising trend, and there is a significant difference between the cities. (2) The difference in the level of synergistic evolution, the second stage of the first stage of synergistic level has been improved, but more than half of the cities are still in the low-level synergistic stage, and there is still a large space for the future to rise. (3) Four paths have evolved from low-level to high-level synergistic evolution, the digital economy-led path, the green technology innovation and digital economy synergy-driven path, the digital economy and ecological resilience synergy-driven path, and the multi-dimensional synergy-driven path, respectively.
Low salt skin preservation with Gossypium hirstum seed-a cleaner approach
Authors: Mahmud Yead , Sarker Shashanka Shekhar , Hossain Md. Mokarom , Ahmed Sharmin , Hossain Md. Khabir , Azad Md. Abul Kashem , Razzaq Md. Abdur 
Published: December 2023

Abstract

Hides and skin preservation has been prominently undergoing salt curing technique for centuries which uses high amount of NaCl (40%) that causes huge amount of total dissolved solids (TDS) and salinity in soaking wastewater of leather processing. Recently, Phyto based preservation is getting emphasis due to being sustainable with less environmental impact. In this study, Gossypium hirstum (cotton) seed powder (5%-7.5%) with 10% salt were applied as a novel source for goatskin preservation. Curing efficiency was monitored by checking organoleptic property, physiochemical property (moisture content, shrinkage temperature, bacterial count, nitrogen content, etc.) at regular interval. Accomplishing the preservation period, preserved skins were processed into shoe upper leather. The pollution parameters were checked from soaking waste liquor to evaluate the environmental impact. SEM analysis and physical properties of the were evaluated to the quality of the produced shoe upper leather. The results revealed that newly developed preservative can preserve goatskin up to 28 days without any deterioration. Experiments reduced pollution by lowering chloride levels 65.33%-66.91%, total dissolved solids by 41.06%-35.2%, biochemical oxygen demand by 30.86%-34.28% percent, and chemical oxygen demand by 41.06%-35.2%. According to the correlation study, there were significant dependencies between the goatskin preservation efficacy parameters, with various strong correlation (r = − 0.976, p<0.001) found between shrinkage temperature and moisture content. Surface topography, physical strength of the produced leather was compatible to conventional shoe upper leather. Thus the introduced seed powder could be one of the valuable sources of eco-friendly leather preservation to reduce environmental pollution.
Bayesian Optimization Acquisition Functions for Accelerated Search of Energy Convex Hull of Multi-Component Alloys
Authors: Wen Dongsheng , Tucker Victoria , Titus Michael 
Published: December 2023

Abstract

Atomistic simulations such as density functional theory and embedded-atom method calculations are essential for predicting many materials properties in the integrated computational materials engineering framework. For many thermodynamic properties, searching the convex hull is necessary to obtain phase stability information for materials selection, synthesis, and characterization in simulations/experiments. With increasingly complicated structures and compositions of materials, the computational cost of the expensive density functional theory calculations has become a barrier to materials design. Thus, there is a need to maximize information gained from each calculation while simultaneously identifying subsequent high-value calculations. In this work, we show that new data acquisition strategies can consider the geometry of the convex hull to maximize the yield of batch experiments done with limited computational resources. Based on Bayesian-Gaussian optimization, we developed uncertainty-based acquisition functions for weighing the conﬁgurations of multi-component alloys to learn the ground-state line. The proposed acquisition methods were validated by learning the formation energy convex hulls of the Co-Ni metallic system, the Zr-O ionic compound system, the Ni-Al-Cr ternary alloys, and the intermetallic (Ni 1−x ,Co x ) 3 Al planar defect system. By comparing to the conventional acquisition scheme using the genetic algorithm models, we demonstrated that the proposed strategies have the advantages of reducing training parameters and user interactions for selecting candidate batch experiments. We show that new acquisition functions can reduce the number of experiments required to obtain the ground-state line error by more than 30%. The new strategies can be extended to multicomponent systems and coupled with cost functions.
A comprehensive investigation of the interactions of human serum albumin with polymeric and hybrid nanoparticles
Authors: Ural Merve Seray , Joseph Joice Maria , Wien Frank , Li Xue , Tran My-An , Taverna Myriam , Smadja Claire , Gref Ruxandra 
Published: December 2023

Abstract
Nanoparticles (NPs) engineered as drug delivery systems continue to make breakthroughs as they offer numerous advantages over free therapeutics. However, the poor understanding of the interplay between the NPs and biomolecules, especially blood proteins, obstructs NP translation to clinics. Nano-bio interactions determine the NPs’ in vivo fate, efficacy and immunotoxicity, potentially altering protein function. To fulfill the growing need to investigate nano-bio interactions, this study provides a systematic understanding of two key aspects: i) protein corona (PC) formation and ii) NP-induced modifications on protein’s structure and stability. A methodology was developed by combining orthogonal techniques to analyze both quantitative and qualitative aspects of nano-bio interactions, using human serum albumin (HSA) as a model protein. Protein quantification via, liquid chromatography-mass spectrometry, and capillary zone electrophoresis (CZE) clarified adsorbed protein quantity and stability. CZE further unveiled qualitative insights into HSA forms (native, glycated HSA and cysteinylated), while synchrotron radiation circular dichroism enabled analyzing HSA’s secondary structure and thermal stability. Comparative investigations of NP cores (organic vs hybrid), and shells (with or without polyethylene glycol (PEG)) revealed pivotal factors influencing nano-bio interactions. Polymeric NPs based on poly(lactic-co-glycolic acid) (PLGA) and hybrid NPs based on metal-organic frameworks (nanoMOFs) presented distinct HSA adsorption profiles. PLGA NPs had protein-repelling properties while inducing structural modifications on HSA. In contrast, HSA exhibited a high affinity for nanoMOFs forming a PC altering thereby the protein structure. A shielding effect was gained through PEGylation for both types of NPs, avoiding the PC formation as well as the alteration of unbound HSA structure.
Energy recovery from the wastes collecting from a biorefining process for butyrate production
Authors: Li Jianzheng , Liu Jiazhi , Pan Zhen , Gao Wenlin , Zhang Yupeng , Meng Jia , Li Jiuling 
Published: December 2023

Abstract

A novel process of alkali-heat pretreatment - mixed culture fermentation was proposed to produce butyric acid from rice straw, but generating alkali-heat pretreatment waste (PW) and butyric acid fermentation waste (FW). In this study, the feasibility of methane fermentation from the wastes was confirmed, with the methane production from PW and FW of 351.1 ± 11.8 and 741.5 ± 14.2 mLCH4/gVS, respectively. The initial pH and VFW/VPW of methane fermentation using the mixed waste of PW and FW were optimized at 7.5 and 1.8, respectively. The methane fermentation using the mixed waste was also verified by operating two anaerobic digesters in sequencing batch mode. At the VFW/VPW of 0.25 (actual ratio), methane production was 301.20 mLCH4/gVS with the waste load of 0.64 kgVS/m³/d. When the VFW/VPW was 1.8 (optimal ratio), methane production reached 396.45 mLCH4/gVS at the waste load of 1.20 kgVS/m3/d. This study facilitates the comprehensive utilization of all components within rice straw.
A case report of diffuse renal cortical necrosis in sickle cell trait
Authors: Alnasrallah Basil , Alqawain Abdullah , Alabbad Eman , Aljishi Manaf , Alzayer Husam , Khuraidah Zainab Al , Aljishi Mohammed Mansour , Alrubh Jafar , Alkhamees Osama , Alfaraj Shatha 
Published: December 2023

Abstract
Background:
Sickle cell disorders are the most common hereditary hematological disorders; they are characterized by a genetic mutation at the ß-globin locus, the heterozygous inheritance leads to sickle cell trait (SCT), a largely benign phenotype with mild clinical manifestations, if any. Unlike sickle cell disease (SCD), clinical presentations for SCT patients are rarely attributed to their underlying hematological status. Different types of renal manifestations have been identified in SCT. Renal cortical necrosis (RCN) is a rare and severe form of kidney injury that has not been associated in the literature with SCT. We report a case of diffuse RCN with stage 3 of acute kidney injury in a patient with SCT with no apparent trigger and partial recovery.
Case presentation:
A 41-year-old non-smoker male, with a background of SCT and no other medical history presented with acute abdominal pain and an initial serum creatinine of 530 μmol/L. His toxicology, viral, and immunological screen were negative with a normal renal ultrasound scan. His urea was 14 mmol/L, hemoglobin of 12 g/dL, normal platelet levels and no schistocytes. His urine protein to creatinine ratio was 1040 mg/g. Lactate dehydrogenase (LDH) and total bilirubin were elevated at 2606 U/L and 31 umol/L, respectively. His kidney biopsy showed diffuse renal cortical necrosis. The patient received conservative therapy and had partial recovery of renal function; his creatinine improved to 176 micromol/L six months later with an eGFR of 42 ml/min/1.73m2
Conclusions:
SCT has long been considered a benign condition. However, recent evidence suggests that, although uncommon, vaso-occlusive manifestations can occur, especially in the context of stressors such as dehydration or physical exhaustion. This is the first described case of diffuse RCN in SCT, highlighting the need for vigilance in managing SCT and its potential severe clinical manifestations.
The development of a complex digital and behavioural Antimicrobial Stewardship intervention for hospitals in England
Authors: Mureyi Dudzai , Cresswell Kathrin , Sivyer Katy , Heed Andrew , Weir Christopher J , Adamestam Imad , Sharp Rona , Ennis Holly , Dogar Omara , Pontefract Sarah , Coleman Jamie , Lilford Richard , Watson Neil , Price David , Hinder Susan , Slee Ann , Chuter Antony , Beggs Jillian , Slight Sarah , Mason James , Sheikh Aziz , Williams Robin 
Published: December 2023

Abstract

Background
Computerised prescribing systems, which are becoming widely adopted, have the potential to improve antimicrobial stewardship, but often lack relevant in-built components to optimally facilitate good antimicrobial stewardship practices.
Objectives
To co-develop with stakeholders, a complex ePrescribing antimicrobial stewardship intervention (ePAMS+) comprising multiple technological and non-technological components, designed to integrate with commercial computerised prescribing (ePrescribing) systems and work processes in hospitals in England.
Methods
ePAMS+’s development was informed by a qualitative person-based approach. This involved literature reviews, structured stakeholder workshops and interviews with policymakers, practitioner and patient representatives, vendors and international experts. Engagements and interviews focused on identifying key barriers to and facilitators of appropriate prescribing and post-prescription reviewing of antimicrobial therapy by users of ePrescribing systems in hospitals. Qualitative data were thematically analysed and, where feasible, used to inform the design ePAMS + features .
Results
Several barriers exist to the implementation of appropriate prescribing and post-prescription review of antimicrobial therapy for users of computerised prescribing systems. These mainly relate to beliefs about what constitutes appropriate antimicrobial use and the inaccessibility of information within ePrescribing systems that would facilitate appropriate prescribing and review. ePAMS + addresses these barriers by making relevant information and tools accessible from within the ePrescribing system.
Conclusions
ePrescribing systems have the potential to facilitate good antimicrobial prescribing and review practice if they incorporate features that make relevant informational resources accessible to healthcare practitioners within ePrescribing systems. Such features can be determined through iterative and structured stakeholder engagement, which can be effective in eliciting requirements for developing interventions, although further adaptations may be necessary after evaluation of early implementation.
The Oncogenic Role and Prognostic Value of PXDN in Human Stomach Adenocarcinoma
Authors: Tian Yuan , Qiu Shenghui , Yang Song , Jiang Yuanjian , Hu Hao , Yang Chengcheng , Cao Jinyong , Chen Shaomin , Hao Mingqing , Li Hongling , Zhu Jianlin 
Published: December 2023

Abstract

Stomach adenocarcinoma (STAD), recognized for its prevalence and poor prognostic profile, necessitates the urgent identification of novel therapeutic targets. Peroxidasin (PXDN), an enzyme with documented peroxidase activity, has been implicated in oncogenesis according to preceding research. However, its specific implications in STAD remain insufficiently characterized. In our investigation, we utilized public databases and clinical specimens to ascertain that PXDN expression is markedly elevated in STAD tissues and serves as an independent prognostic indicator for patient outcomes. Subsequently, our in vitro assays substantiated that PXDN silencing substantially attenuated proliferation, invasion and migration abilities in STAD. Mechanistically, we discovered that PXDN promote epithelial-mesenchymal transition and angiogenic capabilities in STAD cells, and may be regulated by the PI3K/AKT. Further scrutiny unveiled that PXDN levels influence the susceptibility of STAD cells to various chemotherapeutic and small molecule drugs. Moreover, we discerned a significant association between PXDN levels and the abundance of diverse immune cell types within STAD. Crucially, our study elucidated a profound linkage between PXDN level and the tumor immune microenvironment (TIM), proposing PXDN as a viable metric for evaluating the response to immune checkpoint inhibitors. Advancing beyond these findings, we found that PXDN exhibits significant associations with multiple immune checkpoints. In summary, our investigation suggested that PXDN plays critical roles in STAD and its levels could serve as a potential prognostic biomarker. Furthermore, targeting PXDN could offer an effective treatment strategy for STAD.
Using photogrammetry to assess the recovery of a cypress forest and its impact on water-borne erosion. Case study: Guadalupe Island.
Authors: Vera-Ortega Laura Abigail , Hinojosa-Corona Alejandro , Luna Luciana , Gudiño-Elizondo Napoleón 
Published: December 2023

Abstract

We used photogrammetry to assess and monitor the recovery of the cypress forest on Guadalupe Island, Mexico, an ecosystem impaired by fires and overgrazing. Two drone surveys were conducted over the forest area during the summers of 2016 and 2019 with natural color (RGB) and near infrared (NIR) cameras. It is the first complete 3D reconstruction of the cypress forest on the island. The image process products were the canopy height model (CHM), digital surface model (DSM), and digital terrain model (DTM), which were used to calculate the number, density, and height of the trees. The CHM highly correlates with the forest's structure, R = 0.92, according to field measurements of the trees' heights and geo-position. Results account for ~ 67,340 trees higher than two meters in 2019 and a horizontal expansion of 134 ha from 2016 to 2019. Over 90% of the cypress population were young trees between 2 and 3 m that recovered after an extensive fire in 2008. We developed a novel method to calculate the C cover factor of the Revised Universal Soil Loss Equation (RUSLE) using CHM and DSM obtained by photogrammetry. Modeled erosion rates vary from 0 to 2 Kg m− 2y− 1in areas with trees of different ages to values ​greater than 15 Kg m− 2y− 1in areas with steep slopes. According to our results, the derived products from photogrammetry point clouds allow us to describe the vertical structure of the cypress forest with high accuracy and resolution and calculate the cover factor of RUSLE.
Determinants Of Unintended Pregnancy Among Women Attending Antenatal Clinic At AIIMS Patna – A Cross-Sectional Study
Authors: Roy Nilanjan , Kumar Purusottam , Kumari Anuradha , Ahmad Shamshad , Sinha Pragya kumar 
Published: December 2023

Abstract

Background:
Unintended pregnancies remain a global health challenge, impacting women, families, and societies. This study explores the determinants of unintended pregnancies among 289 participants at AIIMS Patna's Antenatal Care clinic.
Methods:
Using a cross-sectional design, data was collected through a structured questionnaire covering sociodemographic details, obstetric parameters, contraceptive practices, and knowledge about contraception. Logistic regression analysis was employed to identify independent predictors of unintended pregnancies.
Results:
Out of 289 participants attending AIIMS Patna's Antenatal Care clinic, 33.2% reported experiencing unplanned pregnancies, highlighting the persistent challenge of unintended pregnancies in the region. Sociodemographic analyses unveiled significant associations with pregnancy planning. Women married before the age of 20 showed a higher likelihood of unintended pregnancies, and those with partners aged 20-29 were more prone to such outcomes. Partner's education and socioeconomic status also played crucial roles, with higher educational attainment and upper socioeconomic status associated with a reduced risk of unplanned pregnancies.
Obstetric parameters exhibited noteworthy associations. Participants with an age at first sexual behavior after 18 years and those with more than one living child were less likely to experience unintended pregnancies. Surprisingly, education demonstrated a paradoxical relationship, as illiterate women had a higher likelihood (56.5%) of unintended pregnancies.
Conclusion:
This study provides comprehensive insights into the determinants of unintended pregnancies among women attending AIIMS Patna's Antenatal Care clinic. The findings emphasize the complex interplay of sociodemographic and obstetric factors in shaping pregnancy intentions. Addressing these multifaceted determinants is crucial for the development of targeted interventions aimed at reducing the prevalence of unintended pregnancies and improving overall reproductive health outcomes in Bihar, India.
Pesticide, trace metal and microbiological analyses of open field and greenhouse–harvested crops from Trinidad before and after processing
Authors: Maharaj Rohanie , Mathura Farrah , Alli Inteaz 
Published: December 2023

Abstract

Greenhouse–grown crops are generally considered safer than open field crops. The study objectives were to determine whether greenhouse–grown crops in Trinidad were safer than open field crops by monitoring microbiological, trace metal and pesticide levels via a “farm-to-fork” approach. Open field tomatoes were compared to those grown in greenhouses over a two-year period. Additionally, greenhouse–grown tomatoes and sweet peppers from the university experimental station were analysed for food safety. Quantitative analyses were based on the presence of 45 pesticide residues, trace metals (lead and cadmium) and microbiological contaminants (faecal coliforms, Staphylococcus aureus and Salmonella sp.). Meals prepared from open field tomatoes in year 2 were analysed for food safety. Neither greenhouse–grown crops (tomatoes and sweet peppers) nor open field tomatoes had a hazardous quantity of the microbes screened or trace metals, except for a batch of open field tomatoes that contained 0.12 mg/kg lead. Eight pesticides (profenofos, ethion, lambda cyhalothrin, cypermethrin, bifenthrin, iprodione, permethrin, and endosulfan) detected in both the open field and greenhouse–grown crops over a two-year period were present below the EU and Codex MRLs, except for a batch of the university experimental station greenhouse–grown tomatoes and sweet peppers, which exceeded the Codex MRL for lambda cyhalothrin. More pesticides were found in year two due to possible additive effects. Meals prepared using tomatoes posed no health risk to children. Overall, the quality of the open field and greenhouse crops was acceptable for consumers, but annual monitoring of these parameters can assure food safety.