bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craving among patients seeking treatment for substance use disorder
Authors: Cless Mallory M. , Courchesne-Krak Natasia S. , Bhatt Kush V. , Mittal Maria Luisa , Marienfeld Carla B. 
Published: November 2023

Abstract
Background
Craving has been implicated as a central feature of addiction and a predictor of relapse. However, a complete understanding of how craving varies across patient populations is lacking. This study aimed to better inform the effective and accurate use of craving as a clinical prognostic tool for patients with substance use disorders (SUD).

Methods
This cross-sectional study utilized information gathered on patients (n = 112) entering specialty treatment for a SUD. Craving in the prior 30 days was assessed with a single item with other intake questionnaires.

Results
Patients who reported substance use in the last 30 days were more likely to report craving compared to patients who did not report substance use in the last 30 days (AOR = 6.86 [95% CI 2.17–21.7], p-value = 0.001). Patients who reported Hispanic/Latinx ethnicity were less likely to report craving compared to patients who did not report Hispanic/Latinx ethnicity (AOR = 0.28 [95% CI 0.08–0.95], p-value = 0.04). There was no association between craving and Adverse Childhood Events (OR = 1.03 [95% CI 0.84–1.25], p-value = 0.81).

Conclusion
The association between recent substance use and craving supports previous findings. The observed variation in craving among patients who report Hispanic/Latinx ethnicity is novel and suggests socio-cultural influences and possibly genetic factors influencing reported craving amongst patients. Additional research is needed to further understand the underlying factors leading to this finding, in order for better utilization of craving as a clinical indicator across patient populations.
Addressing malaria incidence in Africa through health care expenditure and access to basic sanitation services
Authors: Eboh Alfred , Adebayo Aderonke Omotayo 
Published: November 2023

Abstract
Background
Malaria is a significant public health concern, particularly in sub-Saharan Africa. This study examined the impact of health care expenditure and access to basic sanitation services on malaria incidence in 28 selected African countries from 2000 to 2019.

Methods
The study was anchored on Health Production Function [HPF] model while General Panel Linear Model was adopted to examine the relationships between the variables. The retrospective research design was utilised. The statistical diagnostics tests were performed to check for multicollinearity, hereroskedasticity, normality and model specification using correlation matrix, Breusch Pagan/Cook Weisberg, Shapiro–Wilk and the Hausman specification. The hypotheses were tested at the 5% significance level and the analysis of the data was aided by the use of the STATA 13.0.

Results
Domestic Government General Health Expenditure [DGGHE] had a positive relationship with Malaria Incidence [MI], although it was not statistically significant [coefficient = 0.0454708, p-value = 0.604]. Out-Of-Pocket Health Expenditure [OOPHE] demonstrated a statistically significant positive association with MI [coefficient = 0.2839394, p-value = 0.009]. External Health Expenditure [EHE] showed a statistically significant negative relationship with MI [coefficient = − 0.1452344, p-value = 0.012]. Moreover, People using at least Basic Sanitation Services [PBSS] exhibited a statistically significant negative relationship with MI [coefficient = − 0.3854207, p-value = 0.000].

Conclusions
The results suggested that while government health expenditure alone may not significantly impact malaria incidence, increased out-of-pocket expenditure and external health expenditure, as well as improved access to basic sanitation services, are associated with a higher likelihood of reducing malaria incidence in the selected African countries. Addressing malaria incidence in Africa requires a comprehensive approach that includes adequate government health care expenditure, reduction of out-of-pocket costs, increased external funding, and improved access to basic sanitation services. By implementing these recommendations, policymakers can make significant progress in reducing the burden of malaria and improving public health outcomes in affected African countries.
MaSPL16 positively regulates fruit ripening in bananas via the direct transcriptional induction of MaNAC029
Authors: Wei Wei , Yang Ying-ying , Wu Chao-jie , Kuang Jian-fei , Chen Jian-ye , Shan Wei 
Published: November 2023

AbstractFruit ripening (FR) is attributed to the selective expression of several genes precisely governed by various specific transcription factors (TFs). The NAC (NAM, ATAF, and CUC) TF, MaNAC029, positively regulated banana ripening by directly inducing ethylene biosynthesis and transcription of fruit quality-related genes. However, its upstream regulatory mechanism still needs to be clarified. Herein, yeast one-hybrid screening revealed that a SQUAMOSA promoter binding protein-like (SPL) TF, MaSPL16, was a potentially upstream regulator of Musa acuminata NAC (NAM, ATAF, CUC) 029 (MaNAC029). Furthermore, gel mobility shift assay revealed that MaSPL16 can directly bound with the “GTAC” element of the MaNAC029 promoter. The gene expression and promoter activity assays demonstrated that Musa acuminata SPL (SQUAMOSA promoter binding protein-like) 16 (MaSPL16) expression was inducible by ethylene and ripening. MaSPL16 was localized to the nucleus, displayed a potenial capacity for transcriptional activation of MaNAC029. More critically, the transient expression of MaSPL16 in bananas accelerated FR via the upregulation of MaNAC029 and its downstream genes. Collectively, the mechanistic basis of a regulatory cascade involving MaSPL16-MaNAC029 that governed ethylene biosynthesis and fruit quality throughout the entire process of banana fruit ripening was unveiled. These outcomes increase the understanding of the gene-transcriptional regulatory mechanisms in FR. They are envisaged to help devise molecular techniques to regulate maturation and improve future fruit quality.
Antibiotic stewardship in Indian palliative care: a single-center retrospective study
Authors: Thomas David , Kamalumpundi Vijayvardhan , Thampi Amirtha , Lockman Kashelle , Carter Mary B. , Vidwan Navjyot , Broderick Ann 
Published: November 2023

Abstract

Objective:
Characterize antibiotic prescribing behaviors at an Indian palliative care center after the initiation of the Antibiotic Order Form (AOF): an antibiotic stewardship program involving a paper form to track antibiotic use and to provide prescription guidelines.

Design:
Retrospective chart review.

Setting:
Trivandrum Institute of Palliative Sciences (TIPS) is a palliative care organization in Kerala, India.

Methods:
Antibiotic prescription data and patient data were collected for adult patients treated at TIPS between January 1, 2017, and October 31, 2019. Descriptive statistics and a Zero-Inflated Poisson regression model were used to analyze antibiotic prescriptions. AOF completion and prescription concordance with institutional guidelines were also evaluated.

Results:
Out of 7,450 unique patients, 675 (9%) were prescribed 1,448 antibiotics. Age was the strongest factor in determining the number of antibiotic courses with each additional year of age decreasing the expected antibiotic prescription count by 2% per year. The most common antibiotics prescribed were topical metronidazole (44%) and penicillins (29%). Among patients who died, 5% were prescribed antibiotics within the final month of life. In total, 32% of antibiotic prescriptions were documented in AOFs, and 18% were concordant with all institutional antibiotic prescribing guidelines.

Conclusions:
This study is the first to analyze an antibiotic stewardship intervention in a palliative care setting within a low- and middle-income country. This retrospective study provides a benchmark of antibiotic use within Indian palliative care and highlights areas for future stewardship research including topical metronidazole use within palliative care and higher rates of antibiotic use among younger palliative care patients.
We’ll take it from here: Veterans Affairs OPAT management of home IV therapy initiated at community hospitals
Authors: Tiemann Allison R. , Guastadisegni Jessica M. , Kouma Marcus A. , Kelly Kevin C. , Arasaratnam Reuben J. , Storey Donald F. 
Published: November 2023

Abstract
An outpatient parenteral antimicrobial therapy team from a Veterans Affairs facility managed patients discharged from their own facility and neighboring community hospitals. There were no significant differences in adverse outcomes between the groups, but a majority of regimens were modified from those initially proposed by community providers.
Hospital-onset bacteremia and fungemia: examining healthcare-associated infections prevention through a wider lens
Authors: Schrank Gregory M. , Snyder Graham M. , Leekha Surbhi 
Published: November 2023

Abstract
A hospital-onset bacteremia and fungemia (HOB) metric will expand hospital surveillance of bloodstream infections beyond current state and provide an opportunity to re-evaluate infection prevention strategies. Here we consider the added value and potential pitfalls of HOB surveillance and present a framework for the standardized assessment of HOB events.
Coastal management in Brazil from the perspective of the public policy cycle: Analysis of the “multiscale management” proposed in the National Coastal Management Plan
Authors: Pinheiro Giuliana Dos Santos , Tupiassu Lise , Reymão Ana Elizabeth Neirão 
Published: November 2023

Abstract
This article explores the institutionalization of multiscale management in the Brazilian coastal zone, following the National Coastal Management Plan. It employs Secchi’s COQ3 framework to analyze and shed light on this subject. The study uses an exploratory and qualitative approach, employing case studies. It examines the evolution of coastal management in Brazil and highlights the challenges of multiscale management institutionalization. Drawing from Saravia’s public policy cycle insights, it assesses coastal management as a public policy, emphasizing variables and deficiencies in the process. The findings indicate fragmentation and regulatory shortcomings. To achieve integrated management, political cooperation is necessary for aligning interests and effective policy implementation across federal scales, contributing to sustainable coastal resource development in Brazil.
THE SIZE INHERITED AGE EFFECT ON RADIOCARBON DATES OF ALLUVIAL DEPOSITS: REDATING CHARCOAL FRAGMENTS IN A SAND-BED STREAM, MACDONALD RIVER, NSW, AUSTRALIA
Authors: Wood Rachel , King Fleur , Esmay Rebecca , Chen Qianyang , Schneider Larissa , Dotte-Sarout Emilie , Fallon Stewart , Fryirs Kirstie , Gillespie Richard , Blong Russell 
Published: November 2023

ABSTRACTRadiocarbon dates on charred plant remains are often used to define the chronology of archives such as lake cores and fluvial sequences. However, charcoal is often older than its depositional context because old-wood can be burnt and a range of transport and storage stages exist between the woodland and stream or lake bed (“inherited age”). In 1978, Blong and Gillespie dated four size fractions of charcoal found floating or saltating in the Macdonald River, Australia. They found larger fragments gave younger age estimates, raising the possibility that taphonomic modifications could help identify the youngest fragments. In 1978 each date required 1000s charcoal fragments. This study returns to a sample from the Macdonald River to date individual charcoal fragments and finds the inherited age may be more than 1700 years (mode 250 years) older than the collection date. Taphonomic factors, e.g., size, shape or fungal infestation cannot identify the youngest fragments. Only two fragments on short-lived materials correctly estimated the date of collection. In SE Australia, this study suggests that wood charcoal will overestimate the age of deposition, taphonomic modifications cannot be used to identify which are youngest, and multiple short-lived materials are required to accurately estimate the deposition age.
Association between ultra-processed food and flavonoid intakes in a nationally representative sample of the US population
Authors: Leitão Alice Erwig , Roschel Hamilton , Oliveira-Júnior Gersiel , Genario Rafael , Franco Tathiane , Monteiro Carlos Augusto , Martinez-Steele Euridice 
Published: November 2023

AbstractConsumption of ultra-processed food (UPF) has been associated with several chronic diseases and poor diet quality. It is reasonable to speculate that the consumption of UPF negatively associates with flavonoid dietary intake; however, this assumption has not been previously examined. The present study aims to assess association between the dietary contribution of UPF and flavonoid intake in the US population aged 0 years and above. We performed a cross-sectional analysis of dietary data collected by 24-h recalls from 7640 participants participating in the National Health and Nutrition Examination Survey 2017–2018. Foods were classified according to the Nova classification system. The updated US Department of Agriculture (USDA) Database for the Flavonoid Content of Selected Foods (Release 3.3) database was used to estimate total and six classes of flavonoid intakes. Flavonoid intakes were compared across quintiles of dietary contribution of UPF (% of total energy intake) using linear regression models. The total and five out of six class flavonoid intakes decreased between 50 and 70 % across extreme quintiles of the dietary contribution of UPF (Pfor linear trend < 0·001); only isoflavones increased by over 260 %. Our findings suggest that consumption of UPF is associated with lower total and five of six class flavonoid intakes and with higher isoflavone intakes, supporting previous evidence of the negative impact of UPF consumption on the overall quality of the diet and health outcomes.
Taste preferences, cardiometabolic diseases and mild cognitive impairment: a prospective cohort analysis of older Chinese adults
Authors: Yuan Dianqi , Tang Huameng , Yang Peisen , Guo Chao 
Published: November 2023

AbstractTaste preference is a pivotal predictor of nutrient intake, yet its impact on mild cognitive impairment (MCI) remains poorly understood. We aimed to investigate the association between taste preferences and MCI and the role of cardiometabolic diseases (CMD) in this association. The study included older adults, aged 65–90 years, with normal cognitive function at baseline who were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2008 to 2018. MCI was measured by the Mini-Mental State Examination, and multivariable Cox regression models were applied. Among 6423 participants, 2534 (39·45 %) developed MCI with an incidence rate of 63·12 - per 1000 person-years. Compared with individuals with insipid taste, those preferring sweetness or spiciness had a higher MCI risk, while saltiness was associated with a lower risk. This association was independent of objective dietary patterns and was more pronounced among urban residents preferring sweetness and illiterate participants preferring spiciness. Notably, among sweet-liking individuals, those with one CMD experienced a significant detrimental effect, and those with co-occurring CMD had a higher incidence rate of MCI. Additionally, regional variations were observed: sweetness played a significant role in regions known for sweet cuisine, while the significance of spiciness as a risk factor diminishes in regions where it is commonly preferred. Our findings emphasize the role of subjective taste preferences in protecting cognitive function and highlight regional variations. Target strategies should focus on assisting individuals with CMD to reduce excessive sweetness intake and simultaneously receiving treatment for CMD to safeguard cognitive function.
Reversibility of affine transformations
Authors: Gongopadhyay Krishnendu , Lohan Tejbir , Maity Chandan 
Published: November 2023

AbstractAn element g in a group G is called reversible if g is conjugate to g−1 in G. An element g in G is strongly reversible if g is conjugate to g−1 by an involution in G. The group of affine transformations of $\mathbb D^n$ may be identified with the semi-direct product $\mathrm{GL}(n, \mathbb D) \ltimes \mathbb D^n $, where $\mathbb D:=\mathbb R, \mathbb C$ or $ \mathbb H $. This paper classifies reversible and strongly reversible elements in the affine group $\mathrm{GL}(n, \mathbb D) \ltimes \mathbb D^n $.
Bridging Policy and Research in Eldercare
Authors: Keating Norah C. , Fast Janet E. , Connidis Ingrid A. , Penning Margaret , Keefe Janice 
Published: November 2023

AbstractA new paradigm for continuing care policy has emerged that is based on assumptions about the benefits of caring partnerships and client-centred care delivery. Such assumptions place the interface between formal and informal care squarely on the policy agenda. The authors describe how existing research can contribute to the debate stimulated by the new policy paradigm and suggest future research that is informed by the paradigm. They argue that theory is an important tool to make policy agendas more explicit and they use human ecology theory to illustrate how theory can frame the development of research to address policy. Finally, they describe barriers to be overcome in order for policy and research to inform one another.
A Model of Consumer Participation: The Canadian Breast Cancer Initiative
Authors: Parboosingh Jean , Stachenko Sylvie , Inhaber Suzanne 
Published: November 2023

AbstractThe issue of linking research and policy is not unique to health care of the elderly; it has been articulated by numerous stakeholder groups, including those with specific diseases, such as breast cancer. A method of enhancing these links is now being systematically addressed in the Canadian Breast Cancer Initiative with the input of women with breast cancer. The Initiative consists of a number of components and demonstrates a model of consumer participation at multiple levels in setting the agenda for research and policy development, thus enhancing accountability in the transfer of research findings into policy. The concept of consumer participation in linking research and policy is transferable to other diseases and other population groups, such as seniors.
Parliamentary questions as an intra-coalition control mechanism in mixed regimes
Authors: Block Sebastian 
Published: November 2023

AbstractResearch on intra-coalition control shows that monitoring increases with the ideological distance between coalition partners. However, the focus of scholarship has been primarily on parliamentary regimes, not mixed regimes. In mixed regimes, intra-coalition control becomes more complex due to a dual executive. Parties must simultaneously monitor each other and the directly elected Head of Executive (HoE). This article examines intra-coalition control in mixed regimes by analyzing parliamentary questions from 21 German city councils. The German local level resembles a mixed regime. The executive consists of the coalition cabinet supported by the council majority and the directly elected mayor as the HoE. The results show that the division of governmental responsibilities affects intra-coalition control. When a coalition party is aligned with the HoE, the balance of power within the coalition is affected, and the other partners intensify controlling the aligned party. Additionally, policy divisiveness and issue salience are driving factors for intra-coalition control.
NUMAC: Description of the Nested Unified Model With Aerosols and Chemistry, and Evaluation With KORUS‐AQ Data
Authors: Gordon Hamish , Carslaw Ken S. , Hill Adrian A. , Field Paul R. , Abraham Nathan Luke , Beyersdorf Andreas , Corr‐Limoges Chelsea , Ghosh Pratapaditya , Hemmings John , Jones Anthony C. , Sanchez Claudio , Wang Xuemei , Wilkinson Jonathan 
Published: November 2023

AbstractWe describe and evaluate a system for regional modeling of atmospheric composition with the Met Office Unified Model (UM), suitable for climate, weather forecasting and air quality applications. In this system, named NUMAC (“Nested UM with Aerosols and Chemistry”), a global model provides boundary conditions for regional models nested within it, using the Met Office's Regional Nesting Suite for multi‐scale simulations. The regional models, which can run at convection‐permitting or cloud‐resolving scales, use the same code as the global model. The system includes double‐moment prognostic aerosol microphysics with interactive chemistry of sulfur species, ozone, NOx, and CO as in the UK Earth System Model. Double‐moment prognostic cloud microphysics is optional. To test NUMAC, we compare simulations to surface and aircraft measurements from NASA's Korea‐United States Air Quality campaign over South Korea. The performance of the regional model, which we run at 5 km resolution, is similar to the well‐evaluated global model when the regional and global models use the same emissions. Most species such as ozone, NOx, OH, or PM2.5 are simulated within a factor of 2 of observations most of the time, though they are biased low compared to monitors in polluted areas (observed surface dry PM2.5 averages 28 μgm−3 but we simulate 17 μgm−3). Meteorology and clouds are represented satisfactorily. With higher‐resolution emissions, many of the low model biases are reduced, but a tuning was required to keep NO concentrations realistic, indicating shortcomings in the chemistry scheme. We demonstrate the potential of NUMAC for studies of aerosol‐cloud interactions.
External Forcings Caused the Tripole Trend of Asian Precipitation During the Holocene
Authors: Xu Hongna , Wang Tao , Wang Huijun , Chen Shengqian , Chen Jianhui 
Published: November 2023

AbstractTo investigate the evolution of precipitation over Asian continent in the Holocene and the associated mechanisms, we used a set of simulations of the transient climate evolution over the past 21,000 years (TraCE‐21ka), multimodel results from the Paleoclimate Modeling Intercomparison Project Phase 4 (PMIP4), and proxy records in Asia. The TraCE‐21ka results showed a tripole pattern in suborbital‐scale precipitation trends over the Asian continent during the Holocene, with a trend of increase over southern parts of the monsoon regions and arid Central Asia (ACA), and a trend of decline over northern parts of the monsoon regions and their areas of transition with ACA. This tripole pattern was corroborated by proxy records from multiple regions and multimodel results from the PMIP4. Further analysis based on single‐forcing simulations of TraCE‐21ka indicated that influences from different external forcings were different on the Asian precipitation in the main rainy seasons in the Holocene and that their combined effects shaped the tripole pattern. In summer, orbital forcing, by reducing solar radiation in mid‐to‐high latitudes and weakening the land‐sea thermal contrast, has been the dominant factor in the long‐term evolution of precipitation in the monsoon region and West Asia. In winter and spring, changes in meltwater flux played dominant roles in intensifying local water cycle and horizontal moisture advection, which drove the trend of increase in precipitation in ACA. Additionally, changes in greenhouse gas concentration and continental ice sheet forcings both also contribute to the increase in precipitation in ACA.