bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental cerebral aneurysm after takotsubo cardiomyopathy: A case report
Authors: Amaro Tânia , Sgarbi Taynara , Vieira Raísa , Santos Rafael Reis , Matos Priscila , Oliveira Adilson 
Published: October 2023

AbstractTakotsubo syndrome (TS) is an acute heart disease that mimics the typical features of acute coronary syndrome (ACS). TS is generally reported after subarachnoid hemorrhage (SAH) due to a ruptured aneurysm, and has an incidence rate of 0.8 (17%). Here, we report a rare case of TS with unruptured intracranial aneurism. A 54‐year‐old woman had a history of systemic arterial hypertension and migraine. She went to a secondary hospital 2 h after sudden‐onset chest pain, which irradiated to the left upper limb and back. The initial electrocardiogram (ECG) was normal but showed a troponin curve, which led us to suspect acute non‐ST elevation myocardial infarction. Serial ECG showed dynamic changes in ST‐segment elevation in DIII, AvF, V5, and V6. Emergency cardiac catheterisation was performed and did not show any obstructive lesions. However, ventriculography revealed hypokinesia of the inferoapical wall. During hospitalization, the patient had a severe refractory headache. Computed tomography (CT) and CT angiography were performed, which identified “mirror” saccular aneurysms. A supraclinoid internal carotid artery aneurysm was embolized with two stents. The patient's condition progressed satisfactorily. The association between takotsubo syndrome and aneurysmal SAH with some populations has already been reported. Due to this prior knowledge, and severe headache, it was necessary to perform screening for SAH and the discovery of an unruptured aneurysm in this case report. The present case report differs from most reported cases of takotsubo syndrome described in the literature because it presents unruptured mirror aneurysms, while most cases are diagnosed after intracranial hemorrhage.
From Rags to Riches: Exploiting the Calvin‐Benson‐Bassham Cycle for Biomanufacturing
Authors: Federici Filippo , Orsi Enrico , Nikel Pablo Iván 
Published: October 2023

AbstractIndustrial chemical production largely relies on fossil fuels, resulting in the unavoidable release of carbon dioxide (CO2) into the atmosphere. The concept of a circular carbon bioeconomy has been proposed to address this issue, wherein CO2is captured and used as a raw material for manufacturing new chemicals. Microbial cell factories and, in particular, autotrophic microorganisms capable of utilizing CO2as the sole carbon source, emerged as potential catalysts for upcycling CO2to valuable products. The Calvin‐Benson‐Bassham cycle (CBBc), the best‐known CO2fixation pathway, is widely distributed in Nature. While extensively studied, microbial engineering programmes based on the CBBc remains relatively underexplored. In this review, we discuss avenues towards biotechnological exploitation of the CBBc to engineer CO2‐utilizing microbial cell factories, with a focus on chemically‐derived electron donors. We also highlight the advantages and challenges of implementing the CBBc in heterotrophic microbial hosts and its potential to advance a true circular carbon bioeconomy. Moreover, based on the pathway's architecture, we argue about the ideal value‐added products to generate from this metabolic route. Altogether, studying and engineering the CBBc in both natural‐ and synthetic‐autotrophs will enhance our understanding on this CO2fixation pathway, enabling further exploration of biomanufacturing avenues with CO2as feedstock.
Tuning the Electrochemical Properties of Poly‐thiophenes with a 2,5‐Dithienil‐N‐subtituted‐pyrrole Bearing an Aniline Moiety for Electrochromic Devices
Authors: Nicolini Tommaso , Frontana‐Uribe Bernardo A. , Kuhn Alexander , Salinas Gerardo 
Published: October 2023

AbstractConducting polymers find applications as active materials in electrochromic devices thanks to their tunable optoelectronic and electrochemical properties. Such versatility can be further enhanced by copolymerizing various aromatic monomers in order to produce new materials. In this work, we present different copolymers obtained by electropolymerization of an N‐substituted dithienylpyrrole (SNSBA) with either 3,4‐ethylendioxythiophene (EDOT) or bithiophene (BTh). The electrochemical, spectroscopic, and electrical properties were characterized across their different neutral and charged states by means of ex‐situ and in‐situ spectroelectrochemical techniques. The peculiar feature of SNSBA lies in the aniline bearing substituent of the central pyrrole unit that allows polymerization to occur at three different sites, yielding a cross‐linked polymer network. Our findings show that the SNSBA comonomer not only influences the optoelectronic properties of the final materials with respect to their homopolymers, but also induces a lowering of the hysteresis of the insulating/conducting transition (ΔEG<280 mV), likely due to the cross‐linked nature of the polymer layer. These features are promising to develop a new class of copolymers for electrochromic devices with stable, reversible, and fast operation.
Chromatographic method development for simultaneous determination of serotonin, melatonin, and L‐tryptophan: Mass transfer modeling, chromatographic separation factors, and method prediction by artificial neural network
Authors: Tamili Dipshikha , Jana Susovan , Bhattacharjee Paramita 
Published: October 2023

AbstractThis work endeavored to develop a high performance liquid chromatography (HPLC) method for simultaneous quantification of three important biotherapeutic molecules namely, L‐tryptophan, serotonin, and melatonin, present in low amounts in agro‐commodities. In the first approach, using pure chemical standards of the same in a mixture, chromatogram separation parameters such as peak sharpness, peak shouldering, and peak separation were judged by a human panel and biasness‐cum‐decision uncertainties were averted using fuzzy logic analysis. In the second approach, the separation parameters such as peak resolution and separation factors were evaluated to obtain a well‐resolved chromatogram. The parameters of the said separation process were successfully modeled by dimensionless numbers of mass transfer of the analytes in the column; and post‐fitting of mass transfer equations, high R2 was obtained suggesting successful development of the chromatographic process. Euclidean distances between the values of each chromatographic separation parameter and their respective ideal values; the defuzzified scores; findings of mass transfer study; and separation factors concomitantly established that the mobile phase of composition 1% acetic acid in HPLC water (A)–HPLC grade methanol (B) in gradient elution conditions (90% A–10% B) at a flow rate of 1 mL/min could simultaneously quantify the three molecules (μg) in button mushrooms with good resolution. The presence of the said biomolecules in the extract of button mushrooms was also confirmed by electrospray ionization (ESI)‐mass spectrometer (MS). An artificial neural network model (high R2) was also developed for chromatographic users, which would allow accurate prediction of the chromatographic parameters by varying mobile phase composition and flow rates.
Silage production potential of winter cereals and spring corn in rice‐based crop rotations
Authors: Brar Navjot Singh , Hundal Jaspal Singh , Kaur Simerjeet 
Published: October 2023

AbstractRice (Oryza sativa L.)–wheat (Triticum aestivum L. emend. Fiori et Paol.) is the main crop rotation in subtropical conditions of northwestern Indo‐Gangetic plains. To meet fodder demand, corn (Zea mays L.) is grown in spring (February–June) for silage making after short duration oilseed crop (Brassica rapa ssp. oleifera) in rice‐based crop rotation. To fulfill the increasing silage demands, production potential of winter cereals for silage making under rice‐based crop rotations was explored. Rice–wheat (for silage)–spring corn (for silage) (R‐W‐SpM) and rice–barley (for silage) (Hordeum vulgare L.)–spring corn (for silage) (R‐B‐SpM) crop rotations were evaluated for silage production in randomized complete block design with four replications during 2020–2021 and 2021–2022. Rice–wheat (for grains) (R‐W) crop rotation was also evaluated for economic comparison of silage production in rice‐based crop rotations. The silage yield of barley was 15.21% higher as compared with wheat, while silage yield of spring corn grown after barley and wheat was statistically similar. The quality of barley silage was better than wheat. The system silage yield (winter cereal + spring corn) was 9.61% higher in R‐B‐SpM than R‐W‐SpM crop rotation. Rice equivalent yield and gross margin of R‐B‐SpM crop rotation (based on silage yield) were 6.54% and 11.02%, respectively higher than R‐W‐SpM. Silage‐based R‐W‐SpM and R‐B‐SpM crop rotations resulted in 79.19% and 98.93%, respectively higher gross margin than R‐W crop rotation.
Eight‐Membered Palladacycle Intermediate Enabled Synthesis of Cyclic Biarylphosphonates
Authors: Yang Xin‐Xin , Wu Ming‐Ying , Wang Shao‐Qiu , Yang Shang‐Dong 
Published: October 2023

AbstractTransition‐metal‐catalyzed coupling reactions that involve the direct functionalization of insert C−H bond represent one of the most efficient strategies for forming carbon‐carbon bonds. Herein, a palladium‐catalyzed intramolecular C−H bond arylation of triaryl phosphates is reported to access seven‐membered cyclic biarylphosphonate targets. The reaction is achieved via a unique eight‐membered palladacyclic intermediate and shows good functional group compatibility. Meanwhile, the product can be readily converted into other valuable phosphate compounds.
Halogen Bonding Tripodal Metallo‐Receptors for Phosphate Recognition and Sensing in Aqueous‐Containing Organic Media
Authors: Bagha Hena , Hein Robert , Lim Jason Y. C. , Durr Christopher B. , Sambrook Mark R. , Beer Paul D. 
Published: October 2023

AbstractThe anion recognition and electrochemical anion‐sensing properties of halogen‐bonding (XB) tripodal zinc(II) receptors strategically designed and constructed for tetrahedral anion guest binding are described. The XB tris(iodotriazole)‐containing hosts exhibit high affinities and selectivities for inorganic phosphate over other more basic, mono‐charged oxoanions such as acetate and the halides in a competitive CD3CN/D2O (9 : 1 v/v) aqueous solvent mixture. 1H NMR anion binding and electrochemical voltammetric anion sensing studies with redox‐active ferrocene functionalised metallo‐tripodal receptor analogues, reveal each of the XB tripods as superior anion complexants when compared to their tris(prototriazole)‐containing, hydrogen bonding (HB) counterparts, not only exemplifying the halogen bond as a strong alternative interaction to the traditional hydrogen bond for molecular recognition but also providing rare evidence of the ability of XB receptors to preferentially bind the “harder” phosphate oxoanion over the “softer” and less hydrated halides in aqueous containing media.
Marktchancen für den Anlagenbau in der Wasserstoffproduktion
Authors: Haid Michael , Gandert Etwina 
Published: October 2023

AbstractFür die Energiewende ist der Anlagenbau der Schlüssel zum Erfolg. Der Anlagenbauexperte Michael Haid, CEO der EDL Anlagenbaugesellschaft, erklärt im CITplus‐Interview mit Etwina Gandert, welche Voraussetzungen für das Hochlaufen eine nennenswerten Wasserstoffwirtschaft zu erfüllen sind. Er sieht vor allem in den regulatorischen Anforderungen größere Hindernisse, weniger in den technischen Fragen. Außerdem gibt er eine Ausblick auf die effizienten Nutzung von Wasserstoff als Energieträger und zur Produktion klimaschonenderer Chemieprodukte.
Kühlwassersysteme ohne Biozideinsatz betreiben
Authors: Lindemann Eduard , Havighorst Lars 
Published: October 2023

AbstractIn der Wasserbehandlung von industriellen Verdunstungskühlanlagen gab es über Jahre relativ wenige Innovationen. Doch heute können Biozide durch gutartige Mikroorganismen substituiert werden. Mit der Technologie von Blueactivity und dem Service von Lindemann lässt sich die Kühlwasserbehandlung auf natürliche Mikroorganismen umstellen, was Personal und Kosten spart.
Smart Service für Druckluft und Vakuum
Authors: Brand Andreas 
Published: October 2023

AbstractKann Smart Services durch eigenes Personal oder durch Druckluft‐Dienstleister erbracht werden. In der VDMA Orientierungshilfe liegt der Fokus danach auf einzelnen Anwendungsszenarien und beinhaltet auch eine Risikoabschätzung durch erfahrende Druckluft‐ und IT‐Experten.
Design and Synthesis of Novel 2‐Acetamido, 6‐Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors – In vitro Evaluation of their Antiproliferative Activity
Authors: Batsi Yakinthi , Antonopoulou Georgia , Fotopoulou Theano , Koumaki Kassandra , Kritsi Eftichia , Potamitis Constantinos , Goulielmaki Maria , Skarmalioraki Salomi , Papalouka Chara , Poulou‐Sidiropoulou Eleni , Kosmidou Vivian , Douna Stavroula , Vidali Maria‐Sofia , Gkotsi Eleni‐Fani , Chatziioannou Aristotelis , Souliotis Vassilis L. , Pletsa Vasiliki , Papadodima Olga , Zoumpourlis Vassilis , Georgiadis Panagiotis , Zervou Maria , Pintzas Alexander , Kostas Ioannis D. 
Published: October 2023

AbstractThe oncogenic BRAFV600E kinase leads to abnormal activation of the MAPK signaling pathway and thus, uncontrolled cellular proliferation and cancer development. Based on our previous virtual screening studies which issued 2‐acetamido‐1,3 benzothiazole‐6‐carboxamide scaffold as active pharmacophore displaying selectivity against the mutated BRAF, eleven new substituted benzothiazole derivatives were designed and synthesized by coupling of 2‐acetamidobenzo[d]thiazole‐6‐carboxylic acid with the appropriate amines in an effort to provide even more efficient inhibitors and tackle drug resistance often developed during cancer treatment. All derived compounds bore the benzothiazole scaffold substituted at position‐2 by an acetamido moiety and at position‐6 by a carboxamide functionality, the NH moiety of which was further linked through an alkylene linker to a sulfonamido (or amino) aryl (or alkyl) functionality or a phenylene linker to a sulfonamido aromatic (or non‐aromatic) terminal pharmacophore in the order −C6H4−NHSO2−R or reversely −C6H4−SO2N(H)−R. These analogs were subsequently biologically evaluated as potential BRAFV600E inhibitors and antiproliferative agents in several colorectal cancer and melanoma cell lines. In all assays applied, one analog, namely 2‐acetamido‐N‐[3‐(pyridin‐2‐ylamino)propyl]benzo[d]thiazole‐6‐carboxamide (22), provided promising results in view of its use in drug development.
What are the most effective exercise, physical activity and dietary interventions to improve body composition in women diagnosed with or at high‐risk of breast cancer? A systematic review and network meta‐analysis
Authors: Kudiarasu Christine , Lopez Pedro , Galvão Daniel A. , Newton Robert U. , Taaffe Dennis R. , Mansell Lorna , Fleay Brianna , Saunders Christobel , Fox‐Harding Caitlin , Singh Favil 
Published: October 2023

AbstractBackgroundObesity has been recognized as a risk factor in the development and recurrence of breast cancer and is also associated with poor prognostic outcomes. This systematic review and network meta‐analysis aimed to identify the most effective exercise, physical activity, and dietary interventions to reduce fat mass, body fat percentage and body weight as well as potentially increase lean mass in women diagnosed with or at high risk of breast cancer.MethodsA systematic search of databases was performed up to May 2022. Eligible randomized controlled trials examined the effects of exercise, physical activity and/or dietary interventions on fat mass and lean mass in women diagnosed with or at high risk of breast cancer. A random‐effects network meta‐analysis was conducted to determine the effects of different interventions across outcomes when sufficient studies were available.ResultsEighty‐four studies (n = 6428) were included in this review. Caloric restriction and combined exercise + caloric restriction significantly reduced fat mass (range, –3.9 to –3.7 kg) and body weight (range, –5.3 to –4.7 kg), whereas physical activity + caloric restriction significantly reduced body fat percentage (–2.4%; 95% confidence interval [CI], –3.4% to –13%) and body mass index (–2.2 kg × m–2; 95% CI, –3.0 to –1.4 kg × m–2) in breast cancer patients. Resistance exercise was the most effective intervention to increase lean mass (0.7 kg; 95% CI, 0.5–1.0 kg) in breast cancer patients.ConclusionMultimodal exercise and diet programs were the most effective interventions to reduce fat mass, body fat percentage, and body weight and increase and/or preserve lean mass.
Electronic Properties of Transition and Alkaline Earth Metal Doped CuS: A DFT Study
Authors: Oppong‐Antwi Louis , Huang Bosi , Hart Judy N. 
Published: October 2023

AbstractCuS is a unique semiconductor with potential in optoelectronics. Its unusual electronic structure, including a partially occupied valence band, and complex crystal structure with an S−S bond offer unique opportunities and potential applications. In this work, the use of doping to optimize the properties of CuS for various applications is investigated by density functional theory (DFT) calculations. Among the dopants studied, Ni, Zn, and Mg may be the most practical due to their lower formation energies. Doping with Fe, Ni, or Ca induces significant distortion, which may be beneficial for achieving materials with high surface areas and active states. Significantly, doping alters the conductor‐like behavior of CuS, opening a band gap by increasing bond ionicity and reducing the S−S bond covalency. Thus, doping CuS can tune the plasmonic properties and transform it from a conductor to an intrinsic fluorescent semiconductor. Ni and Fe doping give the lowest band gaps (0.35 eV and 0.39 eV, respectively), while Mg doping gives the highest (0.86 eV). Doping with Mg, Ca, and Zn may enhance electron mobility and charge separation. Most dopants increase the anisotropy of electron‐to‐hole mass ratios, enabling device design that exploits directional‐dependence for improved performance.
Adsorption Mechanism of Benzene Derivatives by Pagoda[n]arenes
Authors: Xi Ziqing , Yang Zhenshan , Zhang Xuecheng , Yuan He , Wang Wanting , He Maoxia , Xie Ju 
Published: October 2023

AbstractDespite the widespread use in industrial production, benzene derivatives are harmful to both human beings and the environment. The control of these substances has become an important subject of scientific research. This study introduces a new approach for adsorption and separation of benzene derivatives utilizing pagoda[n]arene based supramolecular materials. Density functional theory calculations were employed to investigate the molecular recognition mechanism of benzene derivatives by pagoda[4]arenes and pagoda[5]arenes (Pa[4]As and Pa[5]As). Results indicate that Pa[4]As and Pa[5]As can effectively accommodate benzene derivatives through non‐covalent interactions, leading to the formation of stable host‐guest complexes. Additionally, molecular dynamics simulations revealed that both crystalline and non‐crystalline supramolecular aggregates of Pa[4]As and Pa[5]As possess the ability to adsorb benzene derivatives and maintain the stability of the adsorption. Moreover, increasing the temperature causes benzene derivatives to desorb from the adsorbing aggregates, and thus the material can be reutilized.
Environmental influence on reproductive traits of buffel grass facultative apomictic genotypes and its implication in plant breeding
Authors: Sánchez Miguel A. , Bruno Cecilia I. , Quiroga Mariana P. , Grunberg Karina A. , Griffa Sabrina M. 
Published: October 2023

AbstractCenchrus ciliaris L., a perennial C4 grass, is one of the most widely used forage species in warm and dry regions worldwide. The widespread use of the cultivar Texas raises concerns about genetic homogeneity and vulnerability. Hybridizations among facultative individuals could widen the genic pool. Therefore, a reproductive characterization of available genotypes is required. The objective of this study was to determine the reproductive mode, potential sexual expressivity, and seed fertility of four facultative apomictic genotypes throughout the flowering season, considering the influence of bioclimatic variables. We assessed the reproductive mode and potential sexual expressivity using the pistil clearing technique and seed fertility based on the production of seeds per panicle under open pollination and self‐pollination. All the assessed genotypes behaved mainly as out‐crossers throughout the flowering season and showed the highest potential sexual expressivity at the beginning of flowering. We confirmed the environmental influence on reproductive traits. At the beginning of the flowering season, the facultative apomictic genotypes exhibited the highest potential as female parent for hybridizations programs.
Scaling up BiVO4 Photoanodes on Porous Ti Transport Layers for Solar Hydrogen Production
Authors: Patil Kunturu Pramod , Lavorenti Marek , Bera Susanta , Johnson Hannah , Kinge Sachin , van de Sanden Mauritius C. M. , Tsampas Mihalis N. 
Published: October 2023

AbstractCommercialization of photoelectrochemical (PEC) water‐splitting devices requires the development of large‐area, low‐cost photoanodes with high efficiency and photostability. Herein, we address these challenges by using scalable fabrication techniques and porous transport layer (PTLs) electrode supports. We demonstrate the deposition of W‐doped BiVO4 on Ti PTLs using successive‐ionic‐layer‐adsorption‐and‐reaction methods followed by boron treatment and chemical bath deposition of NiFeOOH co‐catalyst. The use of PTLs that facilitate efficient mass and charge transfer allowed the scaling of the photoanodes (100 cm2) while maintaining ~90 % of the performance obtained with 1 cm2 photoanodes for oxygen evolution reaction, that is, 2.10 mA cm−2 at 1.23 V vs. RHE. This is the highest reported performance to date. Integration with a polycrystalline Si PV cell leads to bias‐free water splitting with a stable photocurrent of 208 mA for 6 h and 2.2 % solar‐to‐hydrogen efficiency. Our findings highlight the importance of photoelectrode design towards scalable PEC device development.
Fully Bio‐Based Ionic Liquids for Green Chemical Modification of Cellulose in the Activated‐State
Authors: Marcos Celada Lukas , Martín Judith , Dvinskikh Sergey V. , Olsén Peter 
Published: October 2023

AbstractBiopolymers, especially cellulose, are vital to transitioning to a circular economy and reducing our reliance on fossil fuels. However, for many applications a high degree of cellulose hydroxyl modification is necessary. The challenge is that the chemical features of the hydroxyls of cellulose and water are similar. Therefore, chemical modification of cellulose is often explored under non‐aqueous conditions with systems that result in high hydroxyl accessibility and reduce cellulose aggregation. Unfortunately, these systems depend on hazardous and complex solvents from fossil resources, which diverge from the initial sustainability objectives. To address this, we developed three new betaine‐based ionic liquids that are fully bio‐based, scalable, and green. We found that a specific ionic liquid had the perfect chemical features for the chemical activation of cellulose without disturbing its crystalline ordering. The high activation in heterogeneous conditions was exemplified by reacting cellulose with succinic anhydride, resulting in more than 30 % conversion of all hydroxyls on cellulose. Overall, this work opens new perspectives for the derivatization of cellulosic materials while simultaneously “keeping it green”.