bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographics and Clinical Characteristics Associated with the Spread of New‐Onset Laryngeal Dystonia
Authors: Ghanouni Arian , Jona Nikitha , Jinnah Hyder A. , Kilic‐Berkmen Gamze , Shelly Sandeep , Klein Adam M. 
Published: November 2023

ObjectivesAdult‐onset idiopathic laryngeal dystonia (LD) can be associated with the risk of spread to muscles in the body. Subjects with extralaryngeal onset of dystonia have exhibited spread to the larynx. Previous studies analyze the spread of other dystonias but emphasis has not been placed on LD. The objective was to identify demographic and clinical factors contributing to the spread of dystonia to and from the larynx.MethodsData were obtained from the Dystonia Coalition (DC)‐patients from 49 international clinical centers. Clinical and demographic data was taken from 143 out of 409 patients with diagnosed LD. Patient criteria included adult‐onset LD diagnosed on exam with no co‐morbid neurologic conditions and no dystonia in other locations.ResultsAmong the 143 patients, 94 (65.7%) patients were diagnosed with focal laryngeal onset, with the remainder having extralaryngeal onset. Family history and age at study were statistically significant indicators of a patient developing laryngeal versus extralaryngeal onset of dystonia. Among the laryngeal onset group, 21 cases (22.3%) had an average time of 5.81 ± 5.79 years to spread from diagnosis, most commonly to neck (61.9%). Among extralaryngeal onset patients, mean time of larynx spread was 7.92 ± 7.737 years, most commonly to neck (22.7%).ConclusionsOur data indicates approximately a quarter of patients with laryngeal‐onset dystonia will exhibit spread. There were no demographic or clinical factors that were statistically predictive of the likelihood of spread from larynx. Patients with dystonia elsewhere in the body should be counseled on the possibility of spread to larynx, and vice versa.Level of Evidence4 Laryngoscope, 134:2295–2299, 2024
Dual‐responsive polycarbonate micelles for activating intracellular drug release
Authors: Qiu Yuqing , Guo Yuzhe , Yin Wang , Mao Anrong , Zhou Yan , Lang Meidong 
Published: November 2023

AbstractStimulus‐responsive drug carriers have significant potential for enabling smart drug delivery within the intricate microenvironment of tumors. However, a single stimulus source and complex synthesis process limit its application. In this study, we successfully synthesized a pH/GSH‐stimulated responsive polycarbonate (PSSA) through ring‐opening polymerization and post‐esterification reactions. PSSA can self‐assemble into homogeneous and stable micelles, effectively encapsulating the anticancer drug doxorubicin (DOX). The carbon backbone of PSSA contains disulfide and acetal linkages, which allow for extensive responsiveness to changes in pH and GSH. This results in variations in particle size and micellar morphology. The micelles loaded with DOX demonstrate responsive drug‐releasing properties when stimulated by pH/GSH. The dual‐response micelles exhibit superior drug release compared to single stimulus sources. The blank micelles are non‐cytotoxic, while the DOX‐loaded micelles show dose‐dependent cytotoxicity towards HepG2 cells. Importantly, DOX‐loaded micelles enable precise intracellular drug release by responding to the microenvironment of tumor cells. Therefore, this dual‐responsive micellar nano‐carrier, which maintains extracellular stability but activates intracellular drug release, presents a novel approach for smart anti‐tumor drug delivery applications.
Core–sheath structured polystyrene‐ethylene‐butene‐styrene/carbon nanotubes/carbonyl iron particlecomposite fiber with high stretchability for strain and magnetic field dual‐mode sensing
Authors: Li Dongliang , Zhao Jiaqing , Guo Xu , Jiang Jiaqi , Jiang Liang , Chen Shaojuan , Zhou Yanfen , Zhou Feng‐lei 
Published: November 2023

AbstractTo meet the requirement of high stretchability, high sensitivity, and multifunction for flexible sensors, core–sheath structured polystyrene‐ethylene‐butene‐styrene (SEBS)/carbon nanotubes (CNTs)/carbonyl iron particle (CIP) fiber with SEBS/CNTs as the sheath and SEBS/CIP as the core was prepared through wet spinning. The contents of CNTs and CIP in the composite fiber were adjusted by changing the extrusion speed of the SEBS/CNTs and SEBS/CIP spinning solutions. The morphology, electromechanical sensing, and magnetic precepting performances of the fiber were studied. The SEBS/CNTs/CIP fiber sensor showed high stretchability with a maximum strain sensing range of 0%–216.9%, high sensitivity with a gauge factor (GF) of up to 1068.28, as well as excellent durability. In addition, the SEBS/CNTs/CIP fiber sensor exhibited excellent magnetic sensing performance by changing the relative resistance of 35.2% with a magnetic flux density variation of 1.2 T. The applications of SEBS/CNTs/CIP fiber in stretchable circuits, human body motion monitoring, and magnetic field perception were demonstrated.Highlights
SEBS/CNTs/CIP fiber for strain and magnetic field sensing was fabricated.
The SEBS/CNTs/CIP fiber sensor could sense 216.9% strain with GF up to 1068.28.
Relative resistance of SEBS/CNTs/CIP fiber sensor changed by 35.2% under 1.2 T.
SEBS/CNTs/CIP fiber was used in human motion monitoring and magnetic perception.
An energy storage composite using cellulose grafted polyethylene glycol as solid–solid phase change material
Authors: Guo Xi , Jiang He , Qiu Chendong , Lu Tonghua , Wei Renzhong , Fan Mizi , Zhang Yi , Sun Weisheng 
Published: November 2023

AbstractPhase‐change material (PCM) has great thermal energy ability, which has been used as building material for energy conservation. While the most widely used solid–liquid PCM usually appeared leakage during the phase change transition. In order to overcome the leakage of solid–liquid PCM and prepare a viable building energy‐saving materials for indoor temperature regulation, thermal energy storage composites were prepared by utilizing cellulose grafted PEG as phase change material (PCM) and high‐density polyethylene (HDPE) as the substrate. The liquid leakage of PEG was solved after graft to fabricate solid–solid PCM. HDPE is beneficial for solving the leakage and improving the mechanical property by its secondary encapsulation. The synthesized Cellulose‐PEG was characterized by scanning electron microscopy (SEM), X‐ray diffractometer (XRD), and differential scanning calorimetry (DSC). Thermal and mechanical characteristics of the composite were explored. The outcomes revealed that: (1) PEG was successfully grafted to the surface of cellulose and Cellulose‐PEG showed solid–solid phase change behavior. (2) Both the melting‐cooling temperatures and the thermal stability of solid–solid wood plastic composite (SSWPC) had the potential as thermal energy storage material for temperature regulating. (3) The addition of Cellulose‐PEG adversely affected moisture resistance, flexural property, and impact strength due to the weak interface bonding. The physical and mechanical degradation was tolerable for applying situation where mechanical performance is less crucial.Highlights
Cellulose‐PEG showed solid–solid phase change behavior without liquid leakage.
High‐density polyethylene (HDPE) was used as the matrix to realize the second encapsulation of PCM.
Cellulose‐PEG negatively influenced the physical and mechanical property of HDPE.
Solid–solid wood plastic composite presented great thermal storage capacity for indoor temperature regulating.
Effect of BMI and hemoglobin A1c on survival of veterans with metastatic castration‐resistant prostate cancer treated with abiraterone or enzalutamide
Authors: Govindan Srinivas , Cheranda Nina , Riekhof Forest , Luo Suhong , Schoen Martin W. 
Published: November 2023

AbstractBackgroundAbiraterone acetate and enzalutamide are two common therapies for metastatic castration‐resistant prostate cancer (mCRPC) that have shown improved overall survival (OS). The drugs have different mechanisms of action with limited comparative trials to evaluate treatment in patients with comorbidities such as obesity and diabetes. This is important since abiraterone requires the co‐administration of prednisone. We assessed the relationship between body mass index (BMI), hemoglobin A1c (HbA1c), treatment, and survival in mCRPC.MethodsVeterans treated with abiraterone or enzalutamide within the Veterans Health Administration between September 10, 2014 and June 2, 2017 with BMI and HbA1c were identified. Additional variables included age, baseline prostate‐specific antigen at first treatment for mCRPC, race, and the Charlson comorbidity index. Differences in survival were compared using the Kaplan–Meier method. Cox proportional hazards regression modeling was used to assess the association between initial treatment, BMI, and HbA1c while adjusting for confounding variables.ResultsA total of 5231 patients were identified with a mean age of 75.2 years and 1241 (23.7%) were of black race. BMI was associated with OS with longest median survival of 29.8 months in BMI ≥ 30 (n = 1903), 23.9 months in BMI 25–30 (n = 1879), 15.9 months in BMI 18.5–25 (n = 1336), and 9.2 months in BMI < 18.5 (n = 113, p < 0.001). In a multivariable model compared to normal BMI, increased mortality was observed in BMI < 18.5 (adjusted hazard ratio (aHR) = 1.583, 95% confidence interval [CI]: 1.29–1.94) and a decreased mortality in BMI 25–30 (aHR = 0.751, 95% CI: 0.69–0.81) and BMI > 30 (aHR = 0.644, 95% CI: 0.59–0.70). In 3761 patients with BMI > 25, there was longer OS in patients treated with enzalutamide (28.4 months, n = 1615) compared to abiraterone (25.8 months, n = 2146, p = 0.002). In 1470 patients with BMI < 25, there was no difference in OS between patients treated with enzalutamide (16.0 months, n = 597, p = 0.513) or abiraterone (16.1 months, n = 873). In 1333 veterans with HbA1c ≥ 6.5%, initial prescription of enzalutamide was associated with longer OS compared with abiraterone (24.4 vs. 20.5 months, p = 0.0005). In 2088 patients with HbA1c < 6.5%, there was no difference in OS in patients who were initially prescribed enzalutamide versus abiraterone (25.7 vs. 23.5 months, p = 0.334).ConclusionsIn veterans with mCRPC, increased BMI was associated with longer survival. Veterans with BMI > 25 had longer survival with enzalutamide compared to abiraterone. In patients with HbA1c ≥ 6.5%, enzalutamide was associated with longer survival compared to abiraterone. These results may facilitate prognostication of survival and improve treatment selection based on patient comorbidities.
The oriental hornet (Vespa orientalis) as a potential vector of honey bee's pathogens and a threat for public health in North‐East Italy
Authors: Zucca Paolo , Granato Anna , Mutinelli Franco , Schiavon Eliana , Bordin Fulvio , Dimech Marco , Balbo Roberto Andrea , Mifsud David , Dondi Maurizio , Cipolat‐Gotet Claudio , Rossmann Marie Christin , Ocepek Metka Pislak , Scaravelli Dino , Palei Manlio , Zinzula Luca , Spanjol Kimberly 
Published: November 2023

AbstractBackgroundOriental hornets are large predatory hymenoptera that occur in the southern part of Asia and the southeastern Mediterranean. Among many pests of bee colonies, Vespa orientalis was recorded to be one of the most destructive.ObjectivesThe aim of this study was to: (1) monitor the presence of pathogens carried by V. orientalis that could potentially threaten honey bees and public health; (2) describe the hornet's predatory behavior on honey bee colonies and (3) collect the medical history of a V. orientalis sting suffered by a 36‐year‐old woman.MethodsObservations of V. orientalis predatory behavior and the catches of hornets for parasitological and microbiological examination, using molecular and bacteriological analyses, were carried out in three experimental apiaries, both in spring in order to capture the foundress queens and during the summer to capture the workers. Furthermore, the medical history and photographic documentation of a V. orientalis sting suffered by a 36‐year‐old woman have been collected.ResultsThe results obtained highlight that V. orientalis is capable of causing serious damage to beekeeping by killing bees, putting under stress the honey bee colonies and by potentially spreading honey bee pathogens among apiaries. These hornets may also become a public health concern, since they are capable of inflicting multiple, painful stings on humans.ConclusionsOnly the development of an Integrated Management Control Program will be able to contain the negative effects of anomalous population growth and the potentially negative impact on honey bees and public health of V. orientalis.
Iterative Geographic Entity Alignment with Cross-Attention
Authors: Dsouza Alishiba , Yu Ran , Windoffer Moritz , Demidova Elena 
Published: November 2023

AbstractAligning schemas and entities of community-created geographic data sources with ontologies and knowledge graphs is a promising research direction for making this data widely accessible and reusable for semantic applications. However, such alignment is challenging due to the substantial differences in entity representations and sparse interlinking across sources, as well as high heterogeneity of schema elements and sparse entity annotations in community-created geographic data. To address these challenges, we propose a novel cross-attention-based iterative alignment approach called IGEA in this paper. IGEA adopts cross-attention to align heterogeneous context representations across geographic data sources and knowledge graphs. Moreover, IGEA employs an iterative approach for schema and entity alignment to overcome annotation and interlinking sparsity. Experiments on real-world datasets from several countries demonstrate that our proposed approach increases entity alignment performance compared to baseline methods by up to 18% points in F1-score. IGEA increases the performance of the entity and tag-to-class alignment by 7 and 8% points in terms of F1-score, respectively, by employing the iterative method.
Ontology Repositories and Semantic Artefact Catalogues with the OntoPortal Technology
Authors: Jonquet Clement , Graybeal John , Bouazzouni Syphax , Dorf Michael , Fiore Nicola , Kechagioglou Xeni , Redmond Timothy , Rosati Ilaria , Skrenchuk Alex , Vendetti Jennifer L. , Musen Mark ,   members of the OntoPortal Alliance
Published: November 2023

AbstractThere is an explosion in the number of ontologies and semantic artefacts being produced in science. This paper discusses the need for common platforms to receive, host, serve, align, and enable their reuse. Ontology repositories and semantic artefact catalogues are necessary to address this need and to make ontologies FAIR (Findable, Accessible, Interoperable, and Reusable). The OntoPortal Alliance (https://ontoportal.org) is a consortium of research and infrastructure teams dedicated to promoting the development of such repositories based on the open, collaboratively developed OntoPortal software. We present the OntoPortal technology as a generic resource to build ontology repositories and semantic artefact catalogues that can support resources ranging from SKOS thesauri to OBO, RDF-S, and OWL ontologies. The paper reviews the features of OntoPortal and presents the current and forthcoming public and open repositories built with the technology maintained by the Alliance.
5d to 3d compactifications and discrete anomalies
Authors: Sacchi Matteo , Sela Orr , Zafrir Gabi 
Published: November 2023

Abstract
Much insight into the dynamics of quantum field theories can be gained by studying the relationship between field theories in different dimensions. An interesting observation is that when two theories are related by dimensional reduction on a compact surface, their ’t Hooft anomalies corresponding to continuous symmetries are also related: the anomaly polynomial of the lower-dimensional theory can be obtained by integrating that of the higher-dimensional one on the compact surface. Naturally, this relation only holds if both theories are even dimensional. This raises the question of whether similar relations can also hold for the case of anomalies in discrete symmetries, which might be true even in odd dimensions. The natural generalization to discrete symmetries is that the anomaly theories, associated with the lower and higher dimensional theories, would be related by reduction on the compact surface. We explore this idea for compactifications of 5d superconformal field theories (SCFTs) to 3d on Riemann surfaces with global-symmetry fluxes. In this context, it can be used both as a check for these compactification constructions and for discovering new anomalies in the 5d SCFTs. This opens the way to applying the same idea of dimensional reduction of the anomaly theory to more general types of compactifications.
Estimating the cost of functional requirements for tolerance allocation on mechanical assemblies
Authors: Armillotta Antonio 
Published: November 2023

AbstractWhen allocating tolerances to geometric features of machine parts, a target variation must be specified for some functional requirements on the assembly. Such decision, however, is usually made from experience without consideration of its effect on manufacturing cost. To allow such an assessment, the paper describes a method for estimating the cost of a requirement as a function of its variation. The estimation can be done before solving a tolerance allocation problem, at the time the variation on the requirement is chosen as an optimization constraint. A simple expression for the cost of requirements of various types is obtained using the extended reciprocal-power function for the cost of part tolerances, and the optimal scaling method for tolerance allocation. As a result, the costs of both requirement variations and part tolerances can be treated in the same way; this allows a hierarchical approach to tolerance allocation, which can simplify the problem when dealing with complex dimension chains. Furthermore, simple calculations based on the proposed method suggest general cost reduction criteria in the design of assemblies.
Antibacterial Activity of Essential Oils Combinations based on Thymus broussonnetii, and Their Synergism with some Antibiotics
Authors: Amassmoud Oumaima , Abbad Imane , Iriti Marcello , Hassani Lahcen , Mezrioui Noureddine , Abbad Abdelaziz 
Published: November 2023

AbstractThe present study aimed to evaluate the antibacterial activity of the essential oil (EO) of Moroccan endemic Thymus broussonnetii alone, and in combination with EOs obtained from selected medicinal plants, namely Myrtus communis, Artemisia herba alba, Thymus pallidus, Thymus satureioides, Teucrium polium, and Rosmarinus officinalis. The synergistic interactions between the most effective combinations based on T. broussonnetii EO with two conventional antibiotics (streptomycin and ciprofloxacin) were also investigated. T. broussonnetii EO possessed a higher inhibitory activity against tested pathogenic bacteria with inhibition zone diameter (IZ) ranging from 21.61 ± 0.03 to 40.09 ± 0.02 mm, and MIC values between 0.140 mg/mL and 0.280 mg/mL. M. communis, A. herba alba, T. pallidus, T. satureioides, T. polium, and R. officinalis EOs showed moderate to weak antibacterial activity. Among tested EO mixtures, the highest synergistic antibacterial effect was recorded with the EO combination of T. broussonnetii and T. pallidus against S. aureus, E. coli, and S. enterica (FICI = 0.258). This EO combination was also the most effective mixture to synergistically enhance the antibacterial activity of the two antibiotics with up to a 128-fold increase, particularly against the gram-negative E. coli. These findings suggest that T. broussonnetii EO may be an interesting source of natural antimicrobials, for use in combination therapies with other plant EOs, and with conventional antimicrobial drugs to tackle the emergence of multidrug-resistant bacteria.
A validation study of the 30-day questionnaire in the national Norwegian Tonsil Surgery Register: can we trust the data reported by the patients?
Authors: Wennberg Siri , Amundsen Marit Furre , Bugten Vegard 
Published: November 2023

Abstract
Purpose
The aim of this study was to validate the Patient Reported Outcome Measure (PROM) in the Norwegian Tonsil Surgery Register (NTSR) and to examine whether any improvements to the questionnaire could be useful.

Methods
This is a prospective, descriptive study. NTSR collects data from patients who undergo tonsil surgery and the intention of the register is to improve the quality of treatment and to contribute to research. The patients answers questions about admission due to postoperative haemorrhage, infection and pain 30 days after surgery. 305 patients were contacted on phone 1–2 weeks after answering the questionnaires electronically (ePROM) and asked the same questions. 180 of 305 patients we contacted had some kind of complications after surgery. They were asked additional questions to search for possible points for improvement of the questionnaire.

Results
When comparing the results on the ePROM with the answers on phone, we found that 12 out of 14 variables achieve almost perfect agreement (AC1 ≥ 0.81). Two variables are categorized to be substantial agreement (AC1 = 0.61–0.80). The additional questions showed us that the questionnaire can be improved with more detailed information regarding the severity of the postoperative haemorrhage and the need of better treatment against postoperative pain.

Conclusion
This study shows that the information from the 30-day ePROM has high reliability. The questions were understood as they were intended, and the answers reflect what the patients had of complications. Some changes can be done to improve the questionnaire and to open up for more research around the tonsillectomy procedure.
The outcome of polyethylene glycol fusion augmented by electrical stimulation in a delayed setting of nerve repair following neurotmesis in a rat model
Authors: Acharya Nanda , Acharya A. M. , Bhat Anil K. , Upadhya Dinesh , Punja Dhiren , Suhani Sumalatha 
Published: November 2023

Abstract
Purpose
Polyethylene glycol is known to improve recovery following its use in repair of acute peripheral nerve injury. The duration till which PEG works remains a subject of intense research. We studied the effect of PEG with augmentation of 20Htz of electrical stimulation (ES) following neurorrhaphy at 48 h in a rodent sciatic nerve neurotmesis model.

Method
Twenty-four Sprague Dawley rats were divided into 4 groups. In group I, the sciatic nerve was transected and repaired immediately. In group II, PEG fusion was done additionally after acute repair. In group III, repair and PEG fusion were done at 48 h. In group IV, ES of 20Htz at 2 mA for 1 h was added to the steps followed for group III. Weekly assessment of sciatic functional index (SFI), pinprick, and cold allodynia tests were done at 3 weeks and euthanized. Sciatic nerve axonal count and muscle weight were done.

Results
Groups II, III, and IV showed significantly better recovery of SFI (II: 70.10 ± 1.24/III: 84.00 ± 2.59/IV: 74.40 ± 1.71 vs I: 90.00 ± 1.38) (p < 0.001) and axonal counts (II: 4040 ± 270/III: 2121 ± 450/IV:2380 ± 158 vs I: 1024 ± 094) (p < 0.001) at 3 weeks. The experimental groups showed earlier recovery of sensation in comparison to the controls as demonstrated by pinprick and cold allodynia tests and improved muscle weights. Addition of electrical stimulation helped in better score with SFI (III: 84.00 ± 2.59 vs IV: 74.40 ± 1.71) (p < 0.001) and muscle weight (plantar flexors) (III: 0.49 ± 0.02 vs IV: 0.55 ± 0.01) (p < 0.001) in delayed repair and PEG fusions.

Conclusion
This study shows that PEG fusion of peripheral nerve repair in augmentation with ES results in better outcomes, and this benefit can be demonstrated up to a window period of 48 h after injury.