bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional support during pregnancy
Authors: Mozes K. B. , Elgina S. I. , Mozes V. G. , Rudaeva E. V. , Shibelgut N. M. , Chaplygina O. S. , Pomytkina T. E. 
Published: January 2024

Aim: to summarize new data regarding the effectiveness of nutritional support during pregnancy.Materials and Methods. A search for publications was carried out in the PubMed/MEDLINE, Scopus, Web of Science, RSCI databases by retrieving queries for the following keywords: nutritional support, pregnancy, micronutrients, vitamins, macronutrients, without language restrictions. 71 sources with full text access were selected for analysis.Results. Nutritional status during pregnancy markedly impacts on mother's and neonate’s health. During pregnancy, requirements for macro- and micronutrients increase to maintain maternal homeostasis and support fetal growth. Increasing calorie intake in general female population demonstrates modest effects on pregnancy and fetal outcomes, whereas for pregnant women in poor income countries it results in no long-term benefits for children by assessing their anthropometric parameters and neurocognitive development. Despite the lack of conclusive evidence, in many countries sensible calorie restriction during pregnancy is recommended. Some micronutrients are vital for mother and fetus, because their deficiency is accompanied by increased risk of adverse pregnancy outcomes. For instance, folic acid deficiency is associated with the risk of developing fetal neural tube defects, iodine deficiency is coupled to the risk of emerging pediatric intellectual development disorders associated with congenital hypothyroidism, and calcium deficiency is related to a high risk of maternal hypertensive disorders. Therefore, micronutrient supplementation represents a technology with good potential in fighting for maternal and child health. Nonetheless, despite some advances in understanding nutritional support in pregnant women, many studies provide controversial data substantiating a need to conduct further investigations.Conclusion. Overall, recent year research confirms that the supplementation of micro- and macronutrients during pregnancy is an effective tool for “fetal programming” allowing to impact on maternal and fetal health. At the same time, an analysis of the literature showed a significant lack of research in the field of creating individual nutrition programs and nutritional support for pregnant women belonging to different segments of the population, living in different geographical regions, etc.
RISK FACTORS FOR THE DEVELOPMENT OF NOSOCOMIAL PNEUMONIA AFTER AORTIC ARCH SURGERY
Authors: Kalashnikova Tatyana P. , Arsenyeva Yulia A. , Gorchakova Maria B. , Kravchenko Igor V. , Kamenshchikov Nikolay O. , Podoksenov Yuri K. , Panfilov Dmitry S. , Kozlov Boris N. , Boschenko Alla A. 
Published: January 2024

HighlightsFor the first time, the incidence and timing of the development of postoperative pneumonia in patients undergoing surgical reconstruction of the aortic arch in the post-covid period were studied. Risk factors for pneumonia and predictors of the severe course of the disease in this cohort of patients were identified. The results obtained will make it possible to differentiate patients at risk of developing pneumonia from the general population of patients undergoing surgical reconstruction of the aortic arch for targeted perioperative prevention of this complication. AbstractAim. To study the incidence of nosocomial pneumonia (NP) after aortic arch surgery, and to determine the impact of perioperative factors on the risk for its development and severity of its course.Methods. A retrospective analysis of 66 case histories of patients who underwent aortic arch surgery in 2022 was carried out. The incidence and timing of the development of pneumonia were revealed, the severity of its course was assessed. The impact of the main demographic, clinical, perioperative factors on the risk for the pneumonia development and the severity of its course was studied.Results. The incidence of pneumonia after aortic arch surgery was 24.2%. A relationship between smoking (OR 1.17; 95% CI [0.23; 1.43], p = 0.007), smoking index (OR 0.99; 95% CI [0.92; 1.07], p = 0.002) and the risk of NP developing as well as between the duration of mechanical ventilation and the severity of NP was found with a univariate logistic regression analysis (OR 1.26; 95% CI [1.0; 1.59], p = 0.049).Conclusion. The risk for NP development in patients who underwent thoracic aortic surgery is associated with smoking and smoking intensity in the preoperative period. The predictor of the severe course of NP is the duration of mechanical ventilation.
TYPE 2 MYOCARDIAL INFARCTION: MODERN DIAGNOSTIC TECHNIQUES AND TREATMENT
Authors: Motova Anna V. , Karetnikova Viktoriya N. , Osokina Anastasiya V. , Schmidt Evgenia A. , Zhidkova Irina I. , Pecherina Tamara B. , Sedykh Daria Yu. , Kochergina Anastasia M. , Polikutina Olga M. , Barbarash Olga L. 
Published: January 2024

HighlightsPatients with type 2 myocardial infarction have a more favorable course of the disease in the long-term postinfarction period compared with patients with type 1 myocardial infarction. We have determined the differences in clinical and anamnestic characteristics of patients with type 1 and type 2 MI. AbstractAim. To determine the prevalence of patients with type 2 myocardial infarction (MI) and their features in clinical practice.Methods. The prospective study involved 204 patients with acute coronary syndrome (ACS). The inclusion criteria were as follows: diagnosed ACS at admission followed by a confirmed MI during the inpatient period according to the Fourth Universal definition of MI. The following parameters were analyzed: anthropometric parameters, clinical and anamnestic characteristics, results of laboratory tests, biochemical markers of myocardial necrosis, results of instrumental diagnostics and coronary angiography. A follow-up telephone survey was carried out a year after ACS, noting the following endpoints: repeated coronary events, death, repeated hospitalizations, adherence to medical recommendations, medication taken by the patient.Results. Type 2 MI was diagnosed in 22 (10.8%) patients. The results of coronary angiography revealed either the absence of coronary artery (CA) stenosis or the presence of stenosis of less than 50% without indications of thrombosis in 16 (72.7%) of those patients. Chronic total occlusion of a non-infarct-related artery was found in 6 (27.3%) patients. Patients with type 2 MI were comparable in age with patients with type 1 MI. The group of patients with type 2 MI included more women (p = 0.029), fewer smokers (p = 0.037) and more cases of atrial fibrillation (AF) (p = 0.003) compared to patients with type 1 MI. The factors that were associated with type 2 MI were as follows: sinus tachycardia in 3 (13.6%) patients, paroxysmal atrial flutter or AF with ventricular tachysystole in 4 patients (18.2%).Conclusion. Patients with type 1 MI presented with a less favorable course of the disease: we noted higher number of recurrent MI and deaths one year after the index event compared with patients with type 2 MI. The group of patients with type 2 MI consisted mostly of women, fewer smokers and patients with dyslipidemia, as well as a more frequent indication of AF compared with patients with type 1 MI.
Why do I like Schumann more than Chopin? A Physiological Analysis of Pianists' Affinities for Composers
Authors: Watanabe Yuriko , Takeda Shutaro 
Published: January 2024

Understanding students' physiological characteristics is essential in piano teaching. However, how can teachers in the field know what music suits their students physiologically? This paper explores a new theory in sport science called, "the Four-Stance Theory" to provide teachers with a simple yet practical method to understand students' physiological nature. A survey-based experiment with 20 research participants (10 male and 10 female pianists) was conducted. Research participants were physically tested for their physiological "Stance Types" to see if pianists' physiological characteristics can predict their preferences for certain composers' music. Chi-square tests of independence showed that Stance Type can indeed predict what type of composers they favor (p < .05); further, this simple 10-minute physical test could also predict what types of composer's works they feel most technically comfortable to perform (p < .01) and feel are easier to understand (p < .05). These results indicate that this remarkably simple method could effectively discern pianists' physiological nature and predict which composer's music suits them physiologically. The authors envision that this 10-minute test could be useful for bringing physiological preparedness to both teachers and students.
The role of recombination variability to the formation of the population the HIV‐1 population circulating in the Primorsky Krai, Russia
Authors: Halikov M. R. , Ekushov V. E. , Totmenin A. V. , Gotfrid L. G. , Sklyar L. F. , Soloveva N. P. , Serdtseva E. N. , Shportova M. I. , Martynchenko Zh. A. , Beniova S. N. , Ermolickaja S. A. , Gorelova I. S. , Gashnikova N. M. 
Published: January 2024

Aim. To research the molecular epidemiological features of the territorial spread of HIV infection and the influence of recombination variability on the formation of the HIV‐1 population in the Primorsky Krai, Russia. Materials and Methods. A comprehensive analysis of the molecular genetic characteristics of HIV‐1 and clinical‐epidemiological data of 127 HIV‐infected residents of Primorsky Krai was performed. The nucleotide sequences of the pol gene region encoding protease, reverse transcriptase and integrase of HIV‐1 were obtained by the sequencing of amplified fragments of the virus. Genotyping, phylogenetic, and mutational analyses were performed using specialised software resources. Results. In the samples studied of HIV‐1 isolated in the Primorsky Krai, the dominance of HIV‐1 subtype A6 was detected as 40.9 %. The prevalence of subtype B viruses is high compared to other Russian regions – 29.9 %. The HIV‐1 subtype C was found in 6.3 % of the samples studied; circulating recombinant forms CRF63_02A6 – 6.3 %, CRF02_AG – 0.8 %. Unique viruses resulting from the recombination of HIV subtypes A6 and B, A6 and C, C and B were found in 15.7 % of cases (URF_A6C, URF_CB, URF_BA6). Of the 18 HIV‐1 URFs described, 14 were variants of URF_A6C (11 %). Analysis of the near full‐length genome (NFLG) of URF_A6C made it possible to find and describe a new HIV genovariant spreading in Primorye ‐ CRF157_A6C. Conclusion. The analysis of HIV‐1 circulating in the Primorsky Krai confirmed that a specific molecular epidemic situation is developing in the region, which is characterized by active transmission of viruses not only of subtype A6, but also of subtypes B and C, which is not observed in other regions of Russia. For the first time in the Far East, a high frequency of HIV‐1 new unique recombinant forms occurrence has been described, some variants of which are beginning to spread among residents of the Primorsky Krai. An increase in the genetic heterogeneity of the viral population due to recombination variability of HIV is a negative prognostic factor for the territorial epidemic progress of HIV infection in the Far East.
Rust resistance of wheat and triticale samples in different plant growing stages
Authors: Volkova G. V. , Kudinova O. A. , Ignatieva O. O. , Agapova V. D. , Gladkova E. V. , Vaganova O. F. , Matveeva I. P. 
Published: January 2024

Aim. To study resistance to leaf, yellow and stem rusts of winter and spring wheat and winter triticale samples from the collection of the N. I. Vavilov All‐Russian Institute of Plant Genetic Resources (VIR) and breeding centres of southern Russia in different phases of ontogenesis and to identify new sources with group resistance. Material and Methods. The resistance of 158 wheat and triticale samples from the VIR collection and southern breeding centres to populations of leaf, stem and yellow rusts in different plant growth stages was analysed. In the juvenile phase the samples studied were inoculated with populations of rust fungi in climate chambers of the Federal Research Centre of Biological Plant Protection and the type of plant reaction to lesions was noted. In field conditions the samples were evaluated according to the CIMMYT scale on an artificial infectious background. Results. In the adult plant stage under field conditions 79 wheat and triticale samples with group resistance to leaf, yellow and stem rusts were identified, and in the juvenile stage 26 samples. 22 samples showed resistance to three rusts in both phases of ontogenesis. Of these, 5 samples belong to the VIR collection, 3 winter triticale varieties (Dozor, Knyaz, Svat) and the Kavalerka wheat variety selection of the P.P. Lukyanenko National Grain Centre, 9 lines from the Donskoy Agrarian Research Centre and the Federal Rostov Agrarian Research Centre, and 4 winter triticale varieties (Ataman Platov, Zimogor, Kapral, Legion) of selections of the Federal Rostov Agrarian Research Centre. Conclusion. The samples of wheat and winter triticale with group resistance which have been identified are promising for use in breeding for immunity to rust diseases.
Fauna of sone groups of invertebrates of Erebuni State Reserve (Armenia
Authors: Mirumyan L. S. , Harutyunyan R. G. , Marjanyan M. A. , Hovhannisyan V. S. , Avetisyan A. A. , Akopyan N. Ch. , Magomedova M. Z. , Magomedova P. D. , Ghasabyan M. G. , Harutyunova L. D. 
Published: January 2024

Aim. The aim of the work is to research the fauna of invertebrates in the Erebuni State Reserve. Material and Methods. As research material served invertebrates gathered in the Erebuni State Reserve. The work was carried out at the Scientific Centre for Zoology and Hydroecology, National Academy of Sciences, Republic of Armenia in the period 2019–2023. The material was from our own collections, as well as from collections of insects and mollusks of the Institute of Zoology. The identification and collection of insects and mollusks were done using standard methods. Results. An overview of some groups of invertebrates in the Erebuni State Reserve is here provided for the first time. As a result of the research, 35 species of Diptera, 15 species of Coleoptera, 44 species of Lepidoptera,10 species of aphids and 12 species of mollusks were identified. Some species are listed in the “Red Book” of Armenia and are under the protection of the state, and there are rare species and species found in the Republic of Armenia only in the reserve. 15 species of insects identified by us develop on 4 plant species included in the “Red Book” of Armenia. Conclusion. The Erebuni State Reserve is represented by a rather diverse and valuable fauna of invertebrates studied by us, including a number of rare and protected species. Species of invertebrates associated in their development with valuable wild, economically important and protected plants have been identified in the reserve. Identification of species diversity and trophic relationships of some groups of insects that develop on rare and protected plants of the reserve is relevant for natural areas under state protection, of which the Erebuni State Reserve is one.
Determination of quality criteria for candidate standard for anti-D immunoglobulin
Authors: Kalinina E. N. , Vildanova N. S. , Kormshchikova E. S. , Yovdiy A. V. , Smolnikova M. V. 
Published: January 2024

Quality control of medicines is an integral part of the technological cycle, obligatory for the release of products into public distribution. Both in Russia and abroad, when carrying out of laboratory testing of the preparations, it is prescribed to use the reference materials – the certified standard samples. Currently, it is important for the Russian pharmaceutical industry to provide the methods for evaluating the specific activity of human anti-D immunoglobulin with a national standard sample. Its production is impossible without the production of stabilized concentrate of anti-D antibodies and verifying the suitability of each batch for sale. This requires the establishment of specification requirements and the development of regulatory documentation.Aim is to define the quality criteria for candidate standard for anti-D immunoglobulin.Material and methods. The national and foreign normative bases in the field of quality control of blood products, manufacturing and application of biological standards of medicines were analyzed. Three series of lyophilized concentrate of anti-D antibodies were obtained and a laboratory-experimental study of their properties was carried out.Results and discussion. As a result of the work done, technical specifications were approved, including a list of consumer characteristics, a description of the methods for their assessment and relevant norms.Conclusions. The established requirements can become the basis for the releasing quality control of the candidate standard for anti-D immunoglobulin during its serial production.
Study of the fungicidal effect of the chimeric form of interferon alpha-2b in relation to fungi-pathogens of plants and animals
Authors: Maslennikova V. S. , Miroshnichenko C. M. , Shelikhova E. V. , Tabanyukhov K. A. , Deulin I. Yu. , Pykhtina M. B. 
Published: January 2024

The purpose of this study is to evaluate the fungicidal effect of a chimeric form of recombinant interferon alpha-2b, fused with human apolipoprotein A-I, obtained by biosynthesis in the yeast Pichia рastoris, against significant fungal pathogens – pathogens of human and plant diseases.Material and methods. The fungicidal activity of the chimeric cytokine was assessed using the agar block method against fungal pathogens: Alternaria alternata, Fusarium oxysporum, Aspergillus spp. and Penicillum spp. The fungicidal effect was assessed visually and by microscopy of a section of the fungal body stained with methylene blue, the germination of fungal spores – by subculture, the cytotoxicity of interferon preparations – on Vero cell culture.Results and discussion. The studied recombinant interferons suppress the growth and reproduction of pathogenic fungi. Chimeric IFN has the greatest effect against pathogenic fungi A. alternate, Penicillum at a concentration of 15 ng/ml; inhibition of sporulation of fungi F. oxysporum and Aspergillus up to 87 % is achieved at a concentration of 150 ng/ml. The cytotoxicity of the new chimeric cytokine is 5,8 μg/ml, which is significantly more than toxic concentrations for fungi.Conclusions. The chimeric form of interferon alpha-2b can be used as an immunotherapeutic agent with fungicidal activity.
Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus
Authors: Mozgovaya E. E. , Bedina S. A. , Trofimenko A. S. , Spitsina S. S. , Mamus M. A. , Zborovskaya I. A. 
Published: January 2024

Discoid (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of the connective tissue. Along with pathogenetic features, they have common characteristics. Immune disorders and oxidative stress are involved in pathogenesis of DLE and SLE. Development of oxidative stress is closely associated with the activation of xanthine oxidoreductase (XOR) enzyme system.Aim of the study was to reveal the features of XOR activities profiles in blood of DLE and systemic lupus erythematosus (SLE) patients.Material and methods. 31 patients with DLE, 56 patients with SLE, 35 apparently healthy individuals were enrolled in study. The activities of two convertible forms of XOR (xanthine dehydrogenase (XDG; EC 1.17.1.4) and xanthine oxidase (XO; EC 1.17.3.2)) were measured in plasma, lysed WBC and lysed RBC. The level of uric acid (UA) was determined in plasma.Results and discussion. In contrast to the control, XO activity was higher and XDG activity was lower in plasma of DLE patients; activities of both XOR forms were decreased in lysed lymphocytes. Activity of XO was lower in plasma, XO and XDG activities were higher in lysed lymphocytes in DLE regardless of the SLE activity. XDG activity in plasma of and XO activity in lysed erythrocytes DLE patients was lower than in low activity SLE, but higher than in the subgroup with moderate and high disease activity. XDG activity of lysed erythrocytes in DLE was higher than in patients with low and moderate SLE activities, but lower than in patients with high diseases activity. Uric acid content in plasma of DLE patients was not differ from the control values, its level was increased at II and III degrees of SLE activity.Conclusions. Changes in XOR activity in plasma and lysed WBC in DLE and SLE are unidirectional, but are more pronounced in the systemic form of the disease. Thus, DLE and SLE are characterized by some common changes in XOR activity, at the same time, XOR blood profiles have distinctive features, which are characteristic for nosology.
Antiradical and immunomodulatory effects of gynecological capsules developed for complex treatment of diseases of the female reproductive system
Authors: Shikova Yu. V. , Kufterina A. D. , Sakhautdinova I. V. , Bortsova Yu. L. , Fagamov R. R. , Galimova S. Sh. , Galimova E. F. , Mochalov K. S. 
Published: January 2024

Aim of the study was to evaluate the antiradical and immunomodulatory effects of gynecological capsules (ovules) developed for the complex treatment of diseases of the female reproductive system.Material and methods. Antiradical activity of gynecological capsules (ovuli) was evaluated in cell-free model systems by the ability to suppress the hyperproduction of free radical agents caused by the introduction of iron sulfate. Immunomodulatory activity was determined in the whole blood by their effect on the ability of phagocytic cells to generate reactive oxygen species.Results. In cell-free model systems, the studied drug composition suppressed the activation of free radical oxidative processes induced by the iron sulfate, while at the same time enhancing the production of reactive oxygen species by leukocytes.Conclusions. The results obtained may indicate that the developed gynecological capsules have antiradical and immunomodulatory activity, which allows us to consider them as a promising tool for the treatment of diseases of the female reproductive system.
“I Really Felt the Feeling”: A Systematic Review and Qualitative Thematic Synthesis of Healthcare Workers’ Experiences of Acceptance and Commitment Therapy Training
Authors: Huish Ellen , Donnelly Olivia , Marks Elizabeth 
Published: January 2024

Purpose:Existing research suggests that Acceptance and Commitment Therapy (ACT) training is beneficial for healthcare workers’ professional practice and personal well-being. This review aimed to further understanding of healthcare workers’ experiences of ACT training by synthesizing existing qualitative studies.Methods:A systematic literature review identified papers published up until April 2022 using the Embase, Ovid MEDLINE, and PsycINFO databases as well as relevant studies within the gray literature. Nine studies were included in the review, which were analyzed using Thematic Synthesis (Thomas & Harden, 2008).Results:Three analytical themes were identified through the thematic synthesis: I am both the patient and the professional; a powerful and empowering experience; and it is not always comfortable.Conclusion:This review has highlighted the importance of experiential learning. The training was a powerful experience for staff, but as such, it was not always comfortable. Recommendations for the future delivery of ACT training are made.