bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disordered gambling among people with psychotic disorders: a systematic review
Authors: Sankaranarayanan Anoop , Ramanathan Preethi , Mathew Rinu , Wilding Helen , Castle David 
Published: January 2024

AbstractDisorders of gambling are more common among the mentally ill, including in people with psychotic disorders. The aim of this study was to conduct a systematic review of the literature regarding the prevalence and correlates of gambling disorders in people with psychotic disorders. We systematically reviewed English-language literature through searches of six bibliographic databases, all run on 11 November 2022: Medline ALL, Embase, Emcare, APA PsycINFO, CINAHL and the Cochrane Library. Observational studies that reported the prevalence of gambling in psychotic disorders or psychosis among gamblers were included. Studies were critically appraised using the Joanna Briggs Institute Critical Appraisal Tools. Sixteen studies, including 1,116,103 participants, from across a range of settings, were included. Most studies were done on males and recruited participants with a mean age of 40 years. Most of the studies (n = 12) were cross-sectional, and the remaining were case control in design. Most of the studies rated fair in quality. The prevalence of gambling among psychotic population ranged from 0.32 to 19.3%, with the majority of the studies reporting rates between 6.4 and 17%. The rates were 5–25 times higher than in the general population. While there were no consistent associations found with socio-demographic indices, several studies reported an association between gambling behaviours and substance use disorder among those with psychotic illnesses. Our research suggests that clinicians should assess for comorbid gambling among those with psychotic illness, particularly in those with mood symptoms, impulsivity, and substance use disorders. Gambling can negatively impact on their financial and social situations. Future research should study specific strategies or therapies among those with comorbid gambling and psychotic disorders.
A novel antibiotic class targeting the lipopolysaccharide transporter
Authors: Zampaloni Claudia , Mattei Patrizio , Bleicher Konrad , Winther Lotte , Thäte Claudia , Bucher Christian , Adam Jean-Michel , Alanine Alexander , Amrein Kurt E. , Baidin Vadim , Bieniossek Christoph , Bissantz Caterina , Boess Franziska , Cantrill Carina , Clairfeuille Thomas , Dey Fabian , Di Giorgio Patrick , du Castel Pauline , Dylus David , Dzygiel Pawel , Felici Antonio , García-Alcalde Fernando , Haldimann Andreas , Leipner Matthew , Leyn Semen , Louvel Séverine , Misson Pauline , Osterman Andrei , Pahil Karanbir , Rigo Sébastien , Schäublin Adrian , Scharf Sebastian , Schmitz Petra , Stoll Theodor , Trauner Andrej , Zoffmann Sannah , Kahne Daniel , Young John A. T. , Lobritz Michael A. , Bradley Kenneth A. 
Published: January 2024

AbstractCarbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options1. No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years1. Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. A clinical candidate derived from the MCP class, zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CRAB both in vitro and in mouse models of infection, overcoming existing antibiotic resistance mechanisms. This chemical class represents a promising treatment paradigm for patients with invasive infections due to CRAB, for whom current treatment options are inadequate, and additionally identifies LptB2FGC as a tractable target for antimicrobial drug development.
SWECO25: a cross-thematic raster database for ecological research in Switzerland
Authors: Külling Nathan , Adde Antoine , Fopp Fabian , Schweiger Anna K. , Broennimann Olivier , Rey Pierre-Louis , Giuliani Gregory , Goicolea Teresa , Petitpierre Blaise , Zimmermann Niklaus E. , Pellissier Loïc , Altermatt Florian , Lehmann Anthony , Guisan Antoine 
Published: January 2024

AbstractStandard and easily accessible cross-thematic spatial databases are key resources in ecological research. In Switzerland, as in many other countries, available data are scattered across computer servers of research institutions and are rarely provided in standard formats (e.g., different extents or projections systems, inconsistent naming conventions). Consequently, their joint use can require heavy data management and geomatic operations. Here, we introduce SWECO25, a Swiss-wide raster database at 25-meter resolution gathering 5,265 layers. The 10 environmental categories included in SWECO25 are: geologic, topographic, bioclimatic, hydrologic, edaphic, land use and cover, population, transportation, vegetation, and remote sensing. SWECO25 layers were standardized to a common grid sharing the same resolution, extent, and geographic coordinate system. SWECO25 includes the standardized source data and newly calculated layers, such as those obtained by computing focal or distance statistics. SWECO25 layers were validated by a data integrity check, and we verified that the standardization procedure had a negligible effect on the output values. SWECO25 is available on Zenodo and is intended to be updated and extended regularly.
Study on synergistic inhibition and mechanism of flotation separation of fluorite and calcite by tannin and sodium humate
Authors: Zhu Zhi-xiong , Nie Guang-Hua , Tang Yun , Jiang Ying , Tuo Biyang , Li Jiaxin 
Published: January 2024

AbstractAt present, the separation technology of fluorite and calcite is still immature, and the research in this paper can promote the improvement of the separation technology of fluorite and calcite. The selective inhibition mechanism of tannin and humate sodium on calcite was studied by means of actual ore flotation test, single mineral flotation test, Zeta potential measurement and FT-IR spectroscopy. The results show that the mixture of tannin and sodium humate inhibitor has a good inhibitory effect on carbonate under weak alkaline condition. The reaction products of sodium humate, tannin and calcium ions in solution interact with organic compounds adsorbed on the surface of calcite, forming multilayer adsorption on the surface of calcite, making calcite more hydrophilic. Based on density functional theory, Materials Studio (MS) was used to calculate the relevant adsorption energy, and the result was as follows: (a) compared with fluorite, tannin and humate sodium molecules are more easily adsorbed on the surface of calcite. (b) Compared with calcite alone adsorption of tannin molecules or sodium humate molecules, the adsorption state will be more stable, and the effect of tannin and sodium humate synergistic inhibition of calcite is better than the effect of inhibition alone. Therefore, using tannin and sodium humate as a combination inhibitor can effectively separate fluorite and calcite, which will promote the development and utilization of fluorite ore in industry.
Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study
Authors: Coppola L. , Smaldone G. , Grimaldi A. M. , Estraneo A. , Magliacano A. , Soddu A. , Ciccarelli G. , Salvatore M. , Cavaliere C. 
Published: January 2024

AbstractAlthough clinical examination still represents the gold standard for the differential diagnosis of prolonged disorders of consciousness (pDoC), the introduction of innovative markers is essential for diagnosis and prognosis, due to the problem of covert cognition. We evaluated the brain-derived neurotrophic factor protein (BDNF) and the soluble cell adhesion molecules proteins (CAMs) in a cohort of prolonged disorders of consciousness patients to identify a possible application in the clinical context. Furthermore, peripheral blood determinations were correlated with imaging parameters such as white matter hyperintensities (WMH), cranial standardized uptake value (cSUV), electroencephalography (EEG) data and clinical setting. Our results, although preliminary, identify BDNF as a possible blood marker for the diagnosis of pDoC (p value 0.001), the soluble CAMs proteins CD44, Vcam-1, E-selectin (p value < 0.01) and Icam-3 (p value < 0.05) showed a higher peripheral blood value in pDoC compared with control. Finally, soluble Ncam protein could find useful applications in the clinical evolution of the pDoC, showing high levels in the MCS and EMCS subgroups (p value < 0. 001) compared to VS/UWS.
The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells
Authors: Lounas Amel , Breton Yann , Lebrun Ariane , Laflamme Isabelle , Vernoux Nathalie , Savage Julie , Tremblay Marie-Ève , Pelletier Martin , Germain Marc , Richard François J. 
Published: January 2024

AbstractOocyte maturation is a key process during which the female germ cell undergoes resumption of meiosis and completes its preparation for embryonic development including cytoplasmic and epigenetic maturation. The cumulus cells directly surrounding the oocyte are involved in this process by transferring essential metabolites, such as pyruvate, to the oocyte. This process is controlled by cyclic adenosine monophosphate (cAMP)-dependent mechanisms recruited downstream of follicle-stimulating hormone (FSH) signaling in cumulus cells. As mitochondria have a critical but poorly understood contribution to this process, we defined the effects of FSH and high cAMP concentrations on mitochondrial dynamics and function in porcine cumulus cells. During in vitro maturation (IVM) of cumulus-oocyte complexes (COCs), we observed an FSH-dependent mitochondrial elongation shortly after stimulation that led to mitochondrial fragmentation 24 h later. Importantly, mitochondrial elongation was accompanied by decreased mitochondrial activity and a switch to glycolysis. During a pre-IVM culture step increasing intracellular cAMP, mitochondrial fragmentation was prevented. Altogether, the results demonstrate that FSH triggers rapid changes in mitochondrial structure and function in COCs involving cAMP.
Significant reduction of blackfly densities in persistent onchocerciasis area following pilot implementation of an environment friendly approach (Slash and Clear)
Authors: Domche André , Nana Djeunga Hugues C. , Nwane Philippe B. , Njitchouang Guy R. , Nono Fesuh Betrand , Njiokou Flobert , Jacob Benjamin , Pion Sébastien D. , Kamgno Joseph 
Published: January 2024

AbstractThe effectiveness of the “Slash and Clear” method in reducing blackfly populations in low transmission areas is established, but its impact in high transmission settings with large rivers and dense vectors is yet to be proven. A community-based intervention study was conducted in the Mbam Valley, Centre Cameroon, involving two sites: Bayomen (control) and Biatsota (intervention). In each arm, baseline blackfly densities were collected over one year using the human landing method. The intervention consisted of destroying the trailing vegetation where blackflies breed. Blackfly densities were collected post-intervention to assess the impact of the intervention. Post-intervention data showed a 50.8% reduction in blackfly density in Biatsota (mean number of collected blackflies from 1936 to 953), while a reduction of 26.7% was observed in Bayomen (mean number of collected blackflies from 2418 to 1774). The reduction rate attributable to the intervention was 32.9%. Statistical analysis confirmed that the reduction in blackfly density was significantly greater in the intervention site. This study demonstrates the feasibility and significant impact of the “Slash and Clear” method in high transmission areas. However, further research is required to assess its long-term effects and determine how this strategy can be scaled up and sustained until onchocerciasis elimination is achieved.
Forecasting stock prices changes using long-short term memory neural network with symbolic genetic programming
Authors: Li Qi , Kamaruddin Norshaliza , Yuhaniz Siti Sophiayati , Al-Jaifi Hamdan Amer Ali 
Published: January 2024

AbstractThis study introduces an augmented Long-Short Term Memory (LSTM) neural network architecture, integrating Symbolic Genetic Programming (SGP), with the objective of forecasting cross-sectional price returns across a comprehensive dataset comprising 4500 listed stocks in the Chinese market over the period from 2014 to 2022. Using the S&P Alpha Pool Dataset for China as basic input, this architecture incorporates data augmentation and feature extraction techniques. The result of this study demonstrates significant improvements in Rank Information coefficient (Rank IC) and IC information ratio (ICIR) by 1128% and 5360% respectively when it is applied to fundamental indicators. For technical indicators, the hybrid model achieves a 206% increase in Rank IC and an impressive surge of 2752% in ICIR. Furthermore, the proposed hybrid SGP-LSTM model outperforms major Chinese stock indexes, generating average annualized excess returns of 31.00%, 24.48%, and 16.38% compared to the CSI 300 index, CSI 500 index, and the average portfolio, respectively. These findings highlight the effectiveness of SGP-LSTM model in improving the accuracy of cross-sectional stock return predictions and provide valuable insights for fund managers, traders, and financial analysts.
Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery
Authors: Kim Hyunjung , Kim Tae Gyu , Park Byungdo , Kim Jeongho , Jun Si-Youl , Lee Jun Ho , Choi Hee Jun , Jung Chang Shin , Lee Hyoun Wook , Lee Jae Seok , Nam Hyun Yeol , Shin Seunghyen , Kim Sung Min , Kim Haeyoung 
Published: January 2024

AbstractA 2 mm resection margin is considered adequate for ductal carcinoma in situ (DCIS). We assessed the effectiveness of a tailored radiation dose for margins < 2 mm and the appropriate margin width for high-risk DCIS. We retrospectively evaluated 137 patients who received adjuvant radiotherapy after breast-conserving surgery for DCIS between 2013 and 2019. The patients were divided into three– positive, close (< 2 mm), and negative (≥ 2 mm) margin groups. Radiation dose to the tumor bed in equivalent dose in 2 Gy fractions were a median of 66.25 Gy, 61.81 Gy, and 59.75 Gy for positive, close, and negative margin groups, respectively. During a median follow-up of 58 months, the crude rates of local recurrence were 15.0%, 6.7%, and 4.6% in the positive, close, and negative margin groups, respectively. The positive margin group had a significantly lower 5-year local recurrence-free survival (LRFS) rate compared to the close and negative margin groups in propensity-weighted log-rank analysis (84.82%, 93.27%, and 93.20%, respectively; p = 0.008). The difference in 5-year LRFS between patients with the high- and non-high-grade tumors decreased as the margin width increased (80.4% vs. 100.0% for margin ≥ 2 mm, p < 0.001; 92.3% vs. 100.0% for margin ≥ 6 mm, p = 0.123). With the radiation dose tailored for margin widths, positive margins were associated with poorer local control than negative margins, whereas close margins were not. Widely clear margins (≥ 2 mm) were related to favorable local control for high-grade DCIS.
Feeding kinematics of a surgeonfish reveal novel functions and relationships to reef substrata
Authors: Mihalitsis Michalis , Wainwright Peter C. 
Published: January 2024

AbstractBiting to obtain attached benthic prey characterizes a large number of fish species on coral reefs, and is a feeding mode that contributes to important ecosystem functions. We use high-speed video to reveal the mechanisms used by a surgeonfish,Acanthurus leucosternon, to detach algae. After gripping algae in its jaws, the species pulls it by ventrally rotating both the head and the closed jaws, in a novel use of the intra-mandibular joint. These motions remain in the plane of the fish, reducing the use of a lateral head flick to detach the algae. The novel ability to bite and pull algae off the substrate without bending the body laterally minimizes exposure to high water flows, and may be an adaptation to feeding in challenging reef habitats such as the crest and flat. Therefore, our results could potentially represent a key milestone in the evolutionary history of coral reef trophodynamics.
Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival
Authors: Hauck J. Spencer , Moon David , Jiang Xue , Wang Mu-En , Zhao Yue , Xu Lingfan , Quang Holly , Butler William , Chen Ming , Macias Everardo , Gao Xia , He Yiping , Huang Jiaoti 
Published: January 2024

AbstractThere are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the conversion of homocysteine to cystathionine in the transsulfuration pathway by altering levels of cystathionine-β-synthase (CBS). We find that HSF1 directly binds the CBS gene and upregulates CBS mRNA levels. Targeting CBS decreases PCa growth and induces tumor cell death while benign prostate cells are largely unaffected. Combined inhibition of HSF1 and CBS results in more pronounced inhibition of PCa cell proliferation and reduction of transsulfuration pathway metabolites. Combination of HSF1 and CBS knockout decreases tumor size for a small cell PCa xenograft mouse model. Our study thus provides new insights into the molecular mechanism of HSF1 function and an effective therapeutic strategy against advanced PCa.
Routine Echocardiography is not Required in Neonates with Arterial Ischemic Stroke
Authors: Bhagat Indira , Sarkar Rohan , Bapuraj Jayapalli R. , Sarkar Subrata 
Published: January 2024

Objective Current guidelines suggest routine echocardiography (ECHO) in the acute phase to exclude a cardiac source for neonatal arterial ischemic stroke (NAIS). However, the commonly assumed embolic origin from a cardiac source for NAIS is challenged and the need for ECHO in NAIS remains questionable, especially during the era of standard fetal anomaly scanning. Our hypothesis is that any complex cardiac defects potentially causing NAIS would likely be detected during routine prenatal scans, thus possibly making routine postnatal ECHO redundant. This study aimed to determine the prevalence of significant cardiac risk factors and evaluate the necessity of routine postnatal ECHO in NAIS during the routine use of prenatal fetal sonography.
Study Design Retrospective review of 54 infants diagnosed with NAIS via brain magnetic resonance imaging who underwent an ECHO evaluation during the acute period to exclude potential cardiac origins for NAIS.
Results Postnatal ECHO revealed no intracardiac thrombus or vegetation, and only identified structural heart anomalies in three (5%) infants. Interestingly, these three cases had already been diagnosed with syndromic conditions or chromosomal malformations prenatally. In the remaining infants, postnatal ECHO was either normal or showed minor abnormalities unlikely to have contributed to the stroke. The detection rates of complex cardiac anomalies from prenatal scans and postnatal ECHO were statistically similar (p = 0.617).
Conclusion The probability of ECHO to exclude cardiac sources for NAIS is so low that in the era of standard fetal anomaly scanning, routine postnatal ECHO may not be necessary for all NAIS infants, except when chromosomal malformations are detected.
Key Points
Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022
Authors: Dhameliya Tejas M. , Shah Disha D. , Shah Aayushi C. , Shah Tithi S. , Patel Tanvi M. , Rana Devalben K. , Sureja Dipen K. , Bodiwala Kunjan B. 
Published: January 2024

AbstractThe versatility of aza- and oxa-heterocyclic compounds has garnered significant attention in recent times. A large number of currently approved pharmaceutical products include nitrogen- and oxygen-containing heterocycles. Recent nanotechnological developments have propelled an upsurge in the applications of nanocatalysis for heterocyclic synthesis. Metal nanoparticles (MNPs) have emerged as promising catalysts for the synthesis of aza- and oxa-heterocycles owing to their unique physicochemical properties. Various MNPs including gold, silver, nickel and palladium have been evaluated for their catalytic activities in different reaction types, including cyclisation, coupling, hydrogenation and oxidative transformations. The MNPs have exhibited remarkable catalytic efficiency when utilised under optimal conditions. These catalysts have showcased high reusability and recyclability, yielding satisfactory amounts of the desired heterocyclic compound. The present work provides a detailed overview of recent advances in the area of MNP-assisted synthetic construction of aza- and oxa-heterocycles, published during the previous calendar year, 2022. The review serves as a valuable resource and also paves the way for future investigations in the development of novel catalytic strategies for heterocycle synthesis.1	Introduction2	Nanocatalysis3	Aza- and Oxa-Heterocycle Synthesis Catalysed by MNPs3.1	AuNPs3.2	CuNPs3.3	CoNPs3.4	FeNPs3.5	NiNPs3.6	PdNPs3.7	PtNPs3.8	SiNPs3.9	ZnNPs3.10	Bimetallic NPs3.11	Other MNPs4	Summary and Outlook
The effect of fluctuations in bilateral relations on trade: evidence from China and ASEAN countries
Authors: Wang Yuren , Tao Yitao 
Published: January 2024

AbstractChina and ASEAN have strong ties and have become each other’s largest trading partners. This article uses the gravity model and a novel method of analysis, based on massive event data provided by the Global Database of Events, Language, and Tone, to empirically analyse the impact of fluctuations in bilateral relations between China and ASEAN on bilateral trade from January 2001 to December 2020. An analysis of 1,204,126 event records concluded that the improvement of bilateral relations was beneficial for trade between China and ASEAN countries. China’s export trade was more easily influenced by bilateral relations than its import trade. Compared to the one-way behavioural attitude of ASEAN countries towards China, China’s one-way reaction to ASEAN countries had a greater impact on bilateral trade. China’s trade dependence level with most ASEAN countries maintains a trend of steady growth, and trade relations show a positive trend. Therefore, China and ASEAN should maintain stable political ties, enhance mutual understanding, strengthen economic and political connectivity, take adequate measures to promote mutual trust, continue optimizing cooperation models, and promote high-quality and high-level sustainable development across the region.