bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microstructure and properties evolutions of porous Inconel718 alloy by selective laser melting
Authors: Wang Zhiyun , Zhao Zhanyong , Bai Peikang , Ren Juanna , Liu Baosheng , Naik Nithesh , Liu Bin , Qu Hongqiao 
Published: October 2023

Abstract
Nickel-based porous materials possess excellent mechanical properties and can be utilized in the fabrication of diverse lightweight structural materials, holding great potential for applications in the aerospace and automotive sectors. This study focuses on the preparation of porous Inconel718 alloy through selective laser melting and investigates the influence of heat treatment (standard heat treatment, homogenization heat treatment, and homogenization + standardization heat treatment) on the microstructure and properties of the alloy. Inconel718 is a precipitation-strengthened, high-temperature nickel-based alloy. The results indicate that the compressive properties of the porous structures were significantly improved through homogenization heat treatment (the compressive property and energy absorption capacity were increased by 21.8% and 40.4%, respectively). This enhancement can be attributed to the dissolution of a considerable amount of δ phases (Ni3Nb) and Laves phase ((Ni,Cr,Fe)2(Nb,Mo,Ti)) as the solution temperature increased, thereby releasing the strengthening phase -forming element Nb, These Nb elements diffuse uniformly at a high solution temperature, and a large number of nano-sized γ" phases (Ni3Nb) are precipitated in the alloy grains, playing a role of dispersion strengthening and making the strength increase significantly. Moreover, after homogenization heat treatment, the dislocation density is decreased, the crack sensitivity is decreased, and the toughness of the alloy is increased. Consequently, homogenization heat treatment facilitates the dispersion, which thus strengthens the alloy and enhances its compression performance. This study holds significant theoretical and practical implications as it contributes to the advancement of fundamental research on porous high-temperature nickel-based alloys and broadens their range of applications.
Synthesis, structure, Hirschfeld surface analysis and Molecular docking studies of polymorphus of 4-amino 3-nitrobenzoic acid
Authors: Narmanova F. S. , Turaev Kh. Kh. , Kasimov Sh. A. , Ibragimov A. B. , Normamatov A. S. , Balakrishnan C. , Mengnorov I. J. , Eshimbetov A. G. , Ashurov J. M. 
Published: October 2023

Abstract
Single crystals of 4-amino-3-nitrobenzoic acid polymorphic structure (4-A3NBA-P) suitable for X-ray analysis were obtained by the slow evaporation method. New compound structure were studied by IR and UV spectroscopy, thermogravimetric analysis, elemental analysis, as well as Hirshfeld surface analysis and Molecular Docking. Two independently crystallographically distinct molecules that differ only slightly in their geometrical properties make up the compound's asymmetric unit. Depicts the compound's packing diagram, which is made up of four molecules of 4-A3NBA-P. The previously reported 4-A3NBA-P belongs to the monoclinic crystal system with centric space group P21/c (at 100 K) and one molecule in the asymmetric unit, whereas the crystal packs in the triclinic system with a centrosymmetric space group Pī. The cumulative expanse of the Hirschfeld surface encompasses 362.65 Å2. Within this intricate mosaic, a substantive 41.9% is ascribed to interactions of the O•••H/H•••O ilk, while a notable 21.8% is attributable to H•••H interactions. According to molecular docking experiments, the ligand has a strong propensity to bind to KDM4 proteins and the binding energy has improved. The obtained antimicrobial activity data attest that the compounds under study have some antibiotic potential and can be used to make preparations to slow the growth and development of pathogenic bacteria.
Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes
Authors: Cinti Francesca , Leccisotti Lucia , Sorice Gian Pio , Capece Umberto , D'Amario Domenico , Lorusso Margherita , Gugliandolo Shawn , Morciano Cassandra , Guarnieri Andrea , Guzzardi Mariangela , Mezza Teresa , Capotosti Amedeo , Indovina Luca , Ferraro Pietro Manuel , Iozzo Patricia , Crea Filippo , Giordano Alessandro , Giaccari Andrea 
Published: October 2023

Abstract
Objective: We recently demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve in patients with type 2 diabetes (T2D) with stable coronary artery disease (CAD). The mechanism by which this occurs is, however, unclear. One of the risk factors for cardiovascular disease is inflammation of epicardial adipose tissue (EAT). Since the latter is often increased in type 2 diabetes patients, it could play a role in coronary microvascular dysfunction. It is also well known that SGLT-2i modify adipose tissue metabolism.
We aimed to investigate the effects of the SGLT-2i dapagliflozin on visceral and subcutaneous adipose tissue thickness and metabolism in T2D patients with stable coronary artery disease and to verify whether these changes could explain the observed myocardial flow changes.
Methods: We performed a single-center, prospective, randomized, double-blind, controlled clinical trial including 14 patients with T2D randomized 1:1 to SGLT-2i dapagliflozin (10 mg daily) or placebo. The thickness of visceral (epicardial, mediastinal, perirenal) and subcutaneous adipose tissue and glucose uptake were assessed at baseline and 4 weeks after treatment initiation by 2-deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography during hyperinsulinemic euglycemic clamp.
Results: The two groups were well-matched for baseline characteristics (age, diabetes duration, HbA1c, BMI, renal and heart function). Dapagliflozin treatment significantly reduced EAT thickness by 19% (p= 0.03). There was a significant 21.6% reduction in EAT glucose uptake during euglycemic hyperinsulinemic clamp in the dapagliflozin group compared with the placebo group (p=0.014). We did not observe any significant effect on adipose tissue thickness/metabolism in the other depots explored.
Conclusions: SGLT-2 inhibition selectively reduces EAT thickness and EAT glucose uptake in T2D patients, suggesting a reduction of EAT inflammation. This could explain the observed increase in myocardial flow reserve, providing new insights into SGLT-2i cardiovascular benefits.
Microwave radiation-induced interfacial gradient effect of 3D printing CF/PA12 composite for enhancing mechanical performance
Authors: Zhang Huifang , Zhi Jieying , Lu Xiaoxuan , Peng Xuanzhi , Gao Xiaoqing , Yang Yv , Liu Zixuan , Cao Yang , Liu Qichao , Sun Youyi 
Published: October 2023

Abstract
A new carbon fiber/polyamide12 (CF/PA12) composite with ordered orientation is fabricated by combining with 3D printing and microwave radiation. It is found that the tensile strength and modulus of 3D printing CF/PA12 composite with microwave radiation are obviously improved by 23.8% and 10.2% comparing with the original specimen, respectively. The effect of microwave radiation on micro-structure and fiber-matrix interface of 3D printing CF/PA12 composite are investigated by nanoindentation and 3D X-ray computed tomography. The enhanced mechanical properties are mainly attributed to the microwave radiation-induced interfacial gradient effect of 3D printing CF/PA12 composite. The work does not only confirm the formation of 3D printing CF/PA12 composite with good mechanical properties, but also comprehensively clarifies the mechanism of the microwave radiation effect on 3D printing polymer composite based on carbon fiber.
Practice on Framework for Product Quality Analysis Based on User Feedback Data
Authors: Chen Kexuan , Zhang Yanbin , Jiang Chao , Hu Tao , Wang Wei , Su Bin 
Published: October 2023

Abstract
Online products generate vast amounts of user feedback data, which has become crucial for companies to improve product quality and customer satisfaction. This paper proposes the FPQA-UFD (framework to analyze product quality based on user feedback data) using data mining algorithms, natural language processing, multi-classification methods, and statistical analysis, providing detailed data support for product development teams' decision-making. The framework effectively extracts information from user feedback, accurately dividing 305,311 user feedback data into 44 effective topics and extracting explanatory keywords. A multi-classification experiment achieved a classification accuracy and recall rate of 83%. This study offers valuable insights for businesses and academia to enhance decision-making and software development through user feedback analysis.
Serum Elabela expression is decreased in hypertensive patients and could be associated with the progression of hypertensive renal damage
Authors: Tian Geng , Zheng Qian , Zhang Qingru , Liu Xiaoyu , Lu Xuehong 
Published: October 2023

Abstract
Background
Elabela, a recently discovered hormonal peptide containing 32 amino acids, is a ligand for the apelin receptor. It can lower blood pressure and attenuate renal fibrosis. However, the clinicopathological relationship between the Elabela level and renal damage caused by benign hypertension (BHT) and malignant hypertension (MHT) has not been elucidated. Therefore, we discussed the clinicopathological correlation between the serum Elabela level and renal damage caused by BHT and MHT in patients.
Methods
The participants comprised 50 patients and 25 age-matched healthy adults. The 50 patients were separated into two groups: the MHT (n = 25) and BHT groups (n = 25). We analyzed their medical histories, demographics, and clinical examinations, including physical and laboratory tests.
Results
The results showed that the serum Elabela level decreased gradually with a continuous increase in blood pressure from the healthy control group, BHT, to MHT. Moreover, the Elabela levels negatively correlated with BMI(R = − 0.27, P = 0.02), SBP (R = − 0.64, P < 0.01), DBP (R = − 0.58, P < 0.01), Uric acid(R = − 0.39, P < 0.01), BUN (R = − 0.53, P < 0.01), and Scr (R = − 0.53 P < 0.01) but positively correlated with eGFR (R = 0.54, P < 0.01). Stepwise multivariate linear regression analysis showed that SBP was the variable most related to Elabela (t = − 7.029, P < 0.01).
Conclusions
Serum Elabela levels decreased in patients with hypertension, especially malignant hypertension, and had a significant negative correlation with systolic blood pressure.
Trial registration: retrospectively registered approval number:2020076.
Organic matter degradation in the deep, sulfidic waters of the Black Sea: Insights into the ecophysiology of novel anaerobic bacteria
Authors: Yadav Subhash , Koenen Michel , Bale Nicole J , Reitsma Wietse , Engelmann Julia C , Damsté Jaap S. Sinninghe , Villanueva Laura 
Published: October 2023

Abstract
Background:
Recent studies have reported the identity and functions of key anaerobes involved in the degradation of organic matter (OM) in deep (>1,000 m) sulfidic marine habitats. However, due to the lack of available isolates, detailed investigation of their physiology has been precluded. In this study, we cultivated and characterized the ecophysiology of a wide range of novel anaerobes potentially involved in OM degradation in deep (2,000 m depth) sulfidic waters of the Black Sea.
Results:
We have successfully cultivated a diverse physiological group of novel anaerobes belonging to various phyla, including Fusobacteriota (strain S5), Bacillota (strains A1T and A2), Spirochaetota (strains M1T, M2, and S2), Bacteroidota (strains B1T, B2, S6, L6, SYP and M2P), Cloacimonadota (Cloa-SY6), Planctomycetota (Plnct-SY6), Mycoplasmatota (Izemo-BS), Chloroflexota (Chflx-SY6) and Desulfobacterota (strains S3T and S3-i). These microorganisms were able to grow at an elevated hydrostatic pressure of up to 50 MPa.
Moreover, this study revealed that different anaerobes were specialized in degrading specific types of OM. For instance, strains affiliated with the phyla Fusobacteriota, Bacillota, Planctomycetota, and Mycoplasmatota were found to be specialized in the degradation of cellulose, cellobiose, chitin, and DNA, respectively. While strains affiliated with Spirochaetota, Bacteroidota, Cloacimonadota, and Chloroflexota preferred to ferment simpler OM sources. We also identified members of the phylum Desulfobacterota as terminal oxidizers, potentially involved in the consumption of hydrogen produced during fermentation. These results were further supported by the presence of specific metabolic pathways in the (meta)genomes of the cultivated microbial taxa. Additionally, we analyzed the lipid profiles of selected taxa, which could be critical for their survival in the harsh environment of the deep sulfidic waters and could potentially be used as signatures for these strains in the sulfidic waters of the Black Sea.
Conclusions
This is the first report that demonstrates the cultivation and ecophysiology of such a diverse group of microorganisms from any sulfidic marine habitat. Collectively, this study provides a step forward in our understanding of the microbes thriving in the extreme conditions of the deep sulfidic waters of the Black Sea.
Cumulative risk factors, Problematic smartphone use and Depressive symptoms in Nursing Students：a cross-sectional study
Authors: Yang Ya-juan , Granlund Mats , Tao Fang-biao , Tao Shu-man , Zou Li-wei , Wu Xiao-yan , Hong Jing-Fang , Enskar Karin 
Published: October 2023

Abstract
Background
No single risk factor is decisive in shaping an individual's healthy development. This study was to analyze that depressive symptoms are related to a cumulative risk index composed of individual, family and social variables among nursing students.
Methods
We recruited 1716 Chinese nursing students from 3 universities via a paperless survey that measured a set of individual, family and social risk factors of depressive symptoms.
Results
Regardless of the combination of factors, as the number of risk factors increased, the mean of depressive symptom scores also increased, with statistically significant difference, and the proportion of the normal group became lower, the proportion of different depressive symptoms severity groups showed an increasing trend(P <0.001). A high risk cluster of poor sleep quality combined with problematic smartphone use was associated with high levels of depressive symptom (P < 0.001).
Conclusion
The depressive symptoms of nursing students were positively related to the cumulative risk of individual, family and social variables. Among them, a cluster with poor sleep quality combined with problematic smartphone had the highest risk.
CHS-2 is involved in the response of Aedes albopictus larvae to Cadmium stress by mediating the formation of peritrophic membrane
Authors: Zhang Chen , Ding Yanjuan , Lan Ruoyun , Zhou Min , Chen Yanrong , Tang Bin , Wang Shigui 
Published: October 2023

Abstract
Heavy metal stress can affect the growth, development and behavior of insects, Cadmium (Cd) is one of the most seriously polluted heavy metals. Midgut is the main organ for insects to cope with heavy metal stress. chitin synthase-2 (CHS-2) is mainly expressed in the midgut of insects, which is closely related to the formation of the peritrophic membrane (PM) in the midgut. This study vector insects Aedes albopictus as the object, the fourth-instar larvae were exposed to three different concentrations of Cd. The results showed that Cd inhibited the expression of genes related to chitin synthesis and metabolism, and thickened the midgut PM, indicating that the larvae of Ae. albopictus could respond to Cd stress through the midgut PM. Secondly, silencing CHS-2 by RNAi combined with three concentrations of Cd stress, in the absence of the protective effect of midgut PM, Cd stress will lead to more serious vacuolization and deformity of larval midgut epithelial cells, and more intense redox reaction of the insect body, the expression of MT, HSP70 and antioxidant enzyme genes increased, and the activity of antioxidant enzymes also increased at different times. This study confirmed that CHS-2 was involved in the oxidative stress induced by Cd stress by regulating the formation of PM in the midgut of Ae. albopictus, and clarified the resistance of Ae. albopictus to Cd stress and some of the internal mechanisms, which provided a theoretical basis for the related research of using Ae. albopictus to monitor the aquatic environment.
Application Solutions of Highway Freight Information Systems based on Quantum Communication
Authors: Tang Wenliang , Gao Yifan 
Published: October 2023

Abstract
This study proposes an application plan to enhance the security of data transmission in the highway freight information system. The plan utilizes quantum communication technology to encrypt and transmit sensitive data. It involves the use of a quantum key cloud terminal for the unified management of quantum keys and providing key services for the highway freight information system. The system can be accessed through the quantum key cloud service platform. By securely using mobile terminal quantum keys, the overall security of the road freight information system is improved. This scheme ensures the security of the entire system by using a quantum encryption key that is generated only once. The plan defines a quantum key management server and a quantum key cloud platform to manage terminals and quantum keys respectively. These components work together with other hardware facilities and software to produce and distribute quantum keys, ensuring the secure transmission of key information.
Assessment and phenotypic identification of millet germplasm (Setaria italica [L.]) in Liaoning, China
Authors: LI Xin-tong , HE Wei-Feng , WANG Hong-hao , XU Min 
Published: October 2023

Abstract
Millet (Setaria italica [L.]) originated in China and is one of the oldest cultivated crops in the world. The current study aims to assess the present millet germplasms in Liaoning Province scientifically, in order to provide a theoretical basis for the collection, preservation, innovation, and use of millet germplasm resources. This study was conducted from 2018 to 2020. A total of 105 millet germplasm collections were selected from the germplasm resource bank of the Liaoning Academy of Agricultural Sciences. Thirty-one agronomic traits, including 19 qualitative traits and 12 quantitative traits, were observed and recorded. Data were comprehensively evaluated via multivariate analyses, including diversity analysis, correlation analysis, principal component analysis, grey relational analysis, and cluster analysis. Results show that millet resources have abundant diversity, traits represent ear size and ear-bearing capacity were found to be closely related to yield. In high-yield breeding, the resources with upthrow seedling leaves, more tillers, more branches, large ears, and long growth periods should be selected as cross parents. Meanwhile, one early-maturing and lower plant resource, one early-maturing and small-grain resource, one later-maturing and higher plant and big-ear resource, and one later-maturing and big-grain resource were screened for excellent millet breeding.
Association between maternal serum lipid profiles in early pregnancy and the risk of congenital heart disease in offspring: a prospective cohort study
Authors: Zhao Minli , Wang Xinrui , Zhang Danwei , Li Haibo , Sun Bin , Wu Zhengqin , Zhu Yibing , Cao Hua 
Published: October 2023

Abstract

Objective:This study aims to investigate the association of maternal serum lipid profiles in early pregnancy and the risk of congenital heart disease (CHD) in offspring.Methods:This study was based on the Fujian Birth Cohort Study (FJBCS) which was a prospective ongoing study in China. We recruited pregnant women at ≤14 weeks of gestation between 2019 and 2022, and all participants in this study filled out the questionnaire on periconceptional exposure. Simultaneously, we collected participants’ fasting blood samples to measure their lipid profiles by automatic biochemical analyzer. The outcome was defined as offspring with or without CHD. In a multivariable logistic regression model, risk estimates were calculated for associations between maternal lipid profiles and CHD in offspring. Restricted cubic splines were used to estimate the nonlinear relationship between lipid profiles levels and CHD.Results:A total of 21425 pregnant women with an average gestational age of 11.3 (± 1.40) weeks were included in the analysis. The higher triglyceride (TG) (AOR 1.201, 95%CI [1.036,1.394]), low-density lipoprotein (LDL) (AOR 1.216, 95% CI [1.048,1.410]), apolipoprotein B (Apo B) (AOR 2.107, 95% CI [1.179,3.763]) levels were correlated with increased odds of CHD in offspring. The restricted cubic spline suggested a nonlinear relationship between total cholesterol (TC) levels and the risk of CHD in offspring (P=0.0048).Conclusions: Elevated maternal serum lipid profiles levels are associated with an increased risk of CHD in offspring. Additionally, there is a non-linear relationship between TC levels and the risk of CHD in offspring.
Enhanced approach to treating chronic anal fissures: Fissurectomy with vertical non-full-thickness midline sphincterotomy and mucosal advancement flap
Authors: Tsunoda Akira , Kusanagi Hiroshi 
Published: October 2023

Abstract

Purpose Lateral internal sphincterotomy is a conventional surgical intervention for chronic anal fissures, yet the potential for postoperative anal incontinence underscores the need for an alternative approach. This study aimed to evaluate the outcomes of patients with chronic fissures who underwent a combination of fissurectomy, vertical non-full thickness midline sphincterotomy (VNMS), and mucosal advancement flap (MAF), as a means of mitigating the risk of incontinence.
Methods This retrospective analysis included forty-six consecutive patients with chronic anal fissures, unresponsive to topical diltiazem, who underwent fissurectomy combined with VNMS and MAF between April 2018 and May 2023. Primary outcome measures encompassed fissure healing rates. Continence was assessed using the Fecal Incontinence Severity Index (FISI), and manometric assessments were conducted before the procedure and three months postoperatively.
Results With a median follow-up of 27 months, there were no postoperative complications, and the overall fissure healing rate reached 96% (44/46). At three months post-procedure, FISI scores were reduced to 0, with no instances of fecal soiling. Anal resting pressure exhibited a significant reduction at 3 months [pre-op: 133 (95% CI, 128−150) vs. 3 mo: 109 (95% CI, 100−117) cm H2O; p = 0.01]. Similarly, maximum anal squeeze pressure showed a significant decrease three months post-surgery [pre-op: 317 cmH2O (95% CI, 294−380) vs. 3 mo: 291 cmH2O (95% CI, 276−359), p = 0.03].
Conclusion The combination of fissurectomy, VNMS, and MAF proved to be an effective approach for chronic anal fissures, yielding favorable medium-term outcomes without postoperative anal incontinence.