bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Drug Monitoring of Voriconazole in Children with Hematologic
Malignancy and Invasive Fungal Infections: An RCT from a Tertiary Care
Centre in India
Authors: Sharad Neha , Singh Gagandeep , Xess Immaculata , Agarwal Reshu , Seth Tulika , Reeta K.H. , Kothari Sweta 
Published: December 2023

Introduction:
Voriconazole is a triazole anti-fungal with non-linear kinetics and a
narrow therapeutic range. The objective of our study was to monitor the voriconazole serum levels
in children with hematological malignancy and clinically suspected invasive fungal infections.

Methods:
The study was a prospective, randomized controlled trial conducted from June 2016 to
December 2017. All children who had haematologic malignancies with clinically suspected invasive
fungal infections and received voriconazole as the only anti-fungal were included in the
study. The children were randomly allotted into two groups; one was the group that underwent
TDM, and the other, TDM, was not done. Bioassay was the method employed for TDM. The
trough levels were evaluated on a sample obtained on the fifth day of starting the drug. The institute's
ethics committee approved the study.

Result:
A total of 30 children were included in the study: 15 in the TDM group and 15 in the
non-TDM group. The most common underlying malignancy was AML. Neutropenia due to
chemotherapy sessions was these patients' most common risk factor. A favorable outcome was
seen in 13/15 (86.7%) in the TDM group and 11/15 in the non-TDM group (73.3%).

Conclusion:
Only five out of 15 (33.3%) children had voriconazole serum levels within the therapeutic
range. Alterations in dose had to be done in the remaining to achieve the recommended
serum levels. Thus, we recommend TDM for all children of hematologic malignancy receiving
voriconazole for better management. Our findings also revealed that children with AML had
lower than recommended levels of voriconazole on TDM evaluation, whereas those with ALL
had normal to elevated levels of voriconazole.
Recent Trends on Synthesis of Benzimidazoles
Authors: El-Rashedy Ahmed A. , Magd El-Din Asmaa A. , Yousif Nabil M. , Yousif Mahmoud N. M. 
Published: December 2023

Abstract:
Preparation of benzimidazole derivatives have become the interest of many chemists because of the versatile therapeutic activity of benzimidazoles as antiulcer, antimicrobial, anti-viral, anticancer, anti-inflammatory, analgesic and anthelmintic drugs. This review will de-scribe the most recent research on benzimidazole synthesis.
Assessment of the influence of vitamin D level on the course of chronic hepatitis C in comorbidity with chronic pancreatitis
Authors: Derbak M.A. , Buchok O.V. , Ganych T.M. , Rishko O.A. , Timashev V.V. 
Published: December 2023

Background. Chronic hepatitis C (СHC) is often complicated by the presence of concomitant gastrointestinal diseases, one of which is chronic pancreatitis (CP). This has a negative impact on the clinical course of both diseases, contributes to nutrient deficiencies, in particular vitamin D, and worsens the quality of life of patients. The aim of the research was to study the features of the clinical course of CHC in comorbidity with CP and to evaluate the quality of life in patients with different levels of vitamin D in blood serum. Materials and methods. The study included 120 patients who were divided into 2 groups: group 1 — 72 patients with CHC and CP and group 2 — 48 patients with CHC. In turn, patients of group 1, depending on the enzymatic activity of the pancreas, were divided into group 1a (n = 52), which included patients with CHC and CP with exocrine insufficiency (EI), and group 1b (n = 20) — patients with CHC and CP with preserved exocrine function of the pancreas. In all patients, fecal coproscopy was performed, the level of fecal elastase (FE-1), vitamin D, viral load was determined, and the degree of fibrosis and necroinflammatory activity was evaluated using FibroTest and ActiTest. Situational anxiety was assessed according to the Spielberger-Hanin method, and quality of life using the SF-12 questionnaire. The analysis and processing of the results of the examination of patients was carried out using the computer program Jamovi 2.3.2.1, Microsoft Office Excel for Windows 2016 using the Kruskal-Wallis method, the Mann-Whitney-Wilcoxon criterion and the Pearson correlation coefficient. The difference was considered to be statistically significant at p < 0.05. Results. A significantly lower level of vitamin D was found in patients of group 1a than in patients of groups 1b and 2. Patients of group 1 with higher stages of fibrosis (F2–3 and F3–4), a higher degree of necroinflammatory activity in the liver (> A2) and a high viral load have lower levels of vitamin D than those with initial stages of fibrosis and less severe necroinflammatory process in the liver. Patients with CHC, CP and exocrine insufficiency complained of mood changes, increased anxiety, rapid fatigue, and muscle weakness significantly more often than those with preserved exocrine function and patients with CHC. The level of vitamin D in people with CHC, CP and exocrine insufficiency positively correlates with the level of FE-1. In all patients with CHC in comorbidity with CP, a negative effect of low levels of vitamin D on indicators of quality of life and anxiety was found. Conclusions. A reduced level of vitamin D in the blood of patients with CHC and CP worsens the course of the disease and is associated with a decrease in quality of life.
Impairment of auditory function in persons with type 2 diabetes mellitus depending on the level of peripheral myelin protein 22
Authors: Shydlovska T.A. , Navalkivska N.Y. , Kostitska I.O. 
Published: December 2023

Background. One of the priority tasks of modern medicine is early diagnosis and treatment of micro- and macrovascular complications of diabetes mellitus (DM) which cause a decrease in the quality of life of working age people and an increase in mortali­ty. Variability of carbohydrate metabolism indicators, metabolic dysfunction are leading factors in the development and progression of disabling complications of type 2 DM with hearing loss due to degenerative changes in nerve fibers. An important aspect of diagnostic and treatment algorithms of sensorineural hearing disorders in patients with type 2 DM is early detection of demyelinating processes to prevent damage to neuronal structures. The purpose of the study is to determine the relationship between the level of peripheral myelin protein 22 (PMP 22) and the condition of the auditory analyzer according to the data of instrumental examination in patients with type 2 DM combined with hearing impairment. Materials and methods. There were examined 30 patients with type 2 DM (15 men and 15 women aged 56.28 ± 4.54 years) associated with degree I–II sensorineural disorders of the auditory function; 15 people with signs of sensorineural hearing loss (SNHL) (8 men, 7 women aged 59.33 ± 2.65 years) without diabetes and 15 controls. During the examination, the patients with type 2 DM and SNHL, depending on the severity of the underlying disease, were divided into groups: the first group (n = 15) with or without isolated microvascular complications of type 2 DM, the second group (n = 15) with neuro-, nephro- and retinopathy. All patients underwent a set of laboratory tests to determine the content of PMP 22 in the blood serum, clinical and instrumental diagnosis of the auditory function. The obtained data were processed statistically, and correlations were identified. Results. The analysis of the results revealed that in patients with type 2 DM and SNHL (groups 1 and 2), the level of peripheral myelin protein 22 significantly increased compared to both controls and the comparison group, and more significantly in those with microangiopathies. The correlations were found bet­ween the most informative indicators reflecting the state of various structures of the hearing analyzer and the content of PMP 22 in the blood serum. Conclusions. A significant increase was revealed in the content of PMP 22 and manifestations of sensorineural hearing loss in patients with type 2 diabetes mellitus associated with microangiopathies that indicate demyelinating processes in the neural structures of the auditory analyzer.
Persepsi Tamu Terhadap Kinerja Karyawan Restoran
Authors: Dwipayana Ida Bagus Made Aditya Ananta , Ismail Deden , Aprinica Ni Putu Isha 
Published: December 2023

Penelitian ini dilakukan untuk mengetahui persepsi tamu terhadap kinerja karyawan berdasarkan 5 indikator (Tangible, Reliability, Responsiveness, Assurance, dan Empathy) dan mengetahui indicator apa saja yang menjadi prioritas bagi pelanggan yang berkunjung ke Rollpin Casual Smart Dine Mataram – Lombok melalui diagram kartesius. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dengan menggunakan kuesioner. Berdasarkan hadil olah kuesioner yang peneliti ajukan ke 32 responden dan kuesioner menunjukan bahwa tingkat harapan tamu terhadap kinerja karyawan berdasarkan 5 indikator masih lebih besar dari pada tingkat kenyataan di lapangan. Dan berdasarkan hasil yang didapat dari diagram kartesius indikator empathy merupakan indikator yang menjadi prioritas bagi tamu namun pelaksanaanya perlu ditekankan lagi. Indikator reliability merupakan indikator yang dianggap kurang penting bagi tamu namun pelaksanaanya dianggap cukup, sedangkan indikator tangible, assurance, dan responsiveness dianggap tidak terlalu penting akan tetapi pelaksanaannya tergolong sangat baik.

This research was conducted to determine guest perceptions of employee performance based on 5 indicators (Tangible, Reliability, Responsiveness, Assurance, and Empathy) and find out what indicators are priorities for customers who visit Rollpin Casual Smart Dine Mataram – Lombok via Cartesian diagram. Data collection techniques used in this research is to use a questionnaire. Based on processing results questionnaire that the researcher submitted to 32 respondents and the questionnaire showed that the level of hope guests on employee performance based on 5 indicators is still greater than the level reality on the ground. And based on the results obtained from the Cartesian diagram of empathy indicators is an indicator that is a priority for guests, but its implementation needs to be emphasized again. The reliability indicator is an indicator that is considered less important for guests however implementation is considered sufficient, while the indicators are tangible, assurance and responsiveness considered not very important, but its implementation is considered very good.
Implementasi Kebijakan Kurikulum Kondisi Khusus Pandemi Covid-19 Pada Pembelajaran Pendidikan Agama Islam Di SMA Negeri 1 Bangkinang Kota
Authors: Farih Imam , Ramli Ramli 
Published: December 2023

Tujuan penelitian untuk mengetahui implementasi kurikulum kondisi khusus pada pembelajaran Pendidikan Agama Islam di SMA Negeri 1 Bangkinang Kota, Faktor pendukung dan penghambat, dan solusi yang diambil apabila didapati faktor penghambat. Penelitian ini menggunakan pendekatan kualitatif, tehnik pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Analisis data menggunakan analisis deskriptif yang menggunakan metode mereduksi data, menganalisa data, dan menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa Implementasi kurikulum yang digunakan di SMA Negeri 1 Bangkinang Kota adalah kurikulum darurat dengan kompetensi inti dan kompetensi dasar yang disederhanakan untuk Kondisi Khusus. Guru membuat perencanaan pembelajaran dengan mengacu kepada kurikulum darurat, pembelajaran dilaksanakan dengan cara pembelajaran jarak jauh (daring), terdapat faktor pendukung yakni sarana dan prasarana yang memadai, dan faktor penghambat adalah kemampuan guru dalam melaksanakan pembelajaran berbasis didgital, solusi yang diambil adalah melakukan pelatihan guru dalam hal pembelajaran berbasis digital.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Analisis Strategi Multiliterasi sebagai Pembelajaran PAI di Sekolah/Madrasah
Authors: Harahap Sri Wahyuni , Mardianto Mardianto , Padli Nasution Muhammad Irwan 
Published: December 2023

This study aims to analyze multiliteracy learning strategies in schools. The research method used is a literature study with a descriptive and analytical approach. The results of the study show that the use of multiliteracy learning strategies in schools has many benefits, such as improving reading, writing and speaking skills in different languages, as well as increasing the development of digital literacy. In addition, multiliteracy learning strategies can also improve critical and creative thinking skills, and facilitate the integration of different cultures. However, the implementation of this strategy has challenges that must be faced, such as a lack of understanding of the concept of multiliteracy by educators, availability of resources, and difficulties in determining what type of literacy should be taught. Therefore, it is recommended that schools pay attention to this multiliteracy learning strategy so that it can provide a holistic and effective learning experience for students.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Kesabaran terhadap Self Acceptance pada Mahasiswa Fakultas Psikologi Universitas Islam Riau
Authors: Islam Dea Nurul , Hidayat Ahmad 
Published: December 2023

Mahasiswa yang menempuh pendidikan di perguruan tinggi akan mengalami berbagai kesulitan seperti permasalahan ingin memiliki citra tubuh yang ideal dan sulitnya menemukan teman yang cocok atau mengalami kesepian. Salah satu faktor yang dapat meningkatkan self acceptance adalah dengan adanya sifat sabar. Kesabaran memiliki pengaruh terhadap pengendalian diri serta pengendalian emosi yang dirasakan sehingga menjadikan mahasiswa dapat menerima dirinya dengan sepenuhnya tanpa syarat. Penelitian dilakukan untuk mengetahui pengaruh kesabaran terhadap self acceptance pada mahasiswa Fakultas Psikologi Universitas Islam Riau. Subjek penelitian berjumlah 135 mahasiswa. Teknik sampling yang digunakan adalah teknik incidental sampling. Metode pengumpulan data menggunakan skala 3-Factor Patience Scale terdiri dari 11 aitem untuk mengukur kesabaran. Self acceptance diukur menggunakan skala Berger’s self-acceptance scale yang terdiri dari 36 aitem. Data dianalisis menggunakan Partial Least Square (PLS) dengan software smartPLS 3.0. Berdasarkan penelitian yang telah dilakukan menunjukkan hasil bahwa kesabaran memiliki pengaruh positif dan signifikan terhadap self acceptance. Artinya, semakin tinggi kesabaran maka semakin tinggi pula self acceptance pada mahasiswa Fakultas Psikologi Universitas Islam Riau.
Conscientiousness dan Self-Regulated Learning Terhadap Prokrastinasi Akademik pada Mahasiswa Jurusan Sistem Komputer
Authors: Syahrina Isna Asyri , Muarifah Alif 
Published: December 2023

Prokrastinasi akademik yang dialami oleh mahasiswa salah satunya disebabkan oleh rasa lelah atau rasa bosan pada proses pembelajaran. Di sisi lain, mahasiswa membutuhkan kemampuan mengorganisasikan diri untuk mencapai tujuannya. Conscientiousness menggambarkan ketekunan seseorang, bekerja keras, mempunyai motivasi, bertanggung jawab, teratur, berorientasi pada hasil, dan memiliki tekad yang kuat. Sedangkan self-regulated learning adalah kemampuan mengatur dan mengarahkan diri, mengelola diri dalam menghadapi tugas-tugas yang sulit dalam belajar. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh conscientiousness dan self-regulated learning terhadap prokrastinasi akademik mahasiswa di jurusan sistem komputer Universitas Putra Indonesia-YPTK Padang. Sampel penelitian ini berjumlah 152 mahasiswa angkatan 2016 sampai 2019 berstatus aktif dengan menggunakan teknik pengambilan sampel simple random sampling. Penelitian dikumpulkan dengan menggunakan tiga skala, yakni skala conscientiousness, skala self-regulated learning dan skala prokrastinasi akademik. Hasil analisis data penelitian menunjukkan conscientiousness dan self-regulated learning berpengaruh simultan terhadap prokrastinasi akademik, conscientiousness berpengaruh negatif dan signifikan terhadap prokrastinasi akademik, self-regulated learning berpengaruh negatif dan signifikan terhadap prokrastinasi akademik. Dengan demikian, conscientiousness dan self-regulated learning mahasiswa akan membuat prokrastinasi akademik menurun dalam proses pembelajaran.
Higher Education Instructor Perception of Helpfulness of Inclusive and Equitable Online Teaching Strategies
Authors: Martin Florence , Oyarzun Beth , Sadaf Ayesha 
Published: December 2023

Online learners are increasingly diverse (NCES, 2022), which underlines the need for instructors to be inclusive and equitable in online teaching. Inclusion refers to providing opportunities for all learners in the online course, so they can actively participate and feel welcomed and belong in the course, and equity ensures that all learners have fair treatment and access to the opportunities and resources needed to succeed. In this survey-based research, we developed an Inclusive and Equitable Online Teaching Strategies (IEOTS) instrument with 45 strategies and examined instructor perceptions of the helpfulness of these strategies. These strategies focused on instructor self-awareness and commitment, getting to know the learners, course design, course facilitation, and evaluation. Based on the 478 online instructor survey responses, descriptive statistics showed that the instructors rated the strategies between somewhat helpful and helpful. In the open-ended question, student choice was described as an important aspect of the online course being inclusive and equitable. Analysis conducted based on the learner (student level), instructor (gender, ethnicity, teaching experience and teaching expertise), course (delivery modality), and organizational differences (required training, collaboration with instructional designer) found that instructor perceptions of helpfulness was higher for the course design subscale for instructors who taught online asynchronously rather than synchronously; higher for the know your learner subscale for instructors who taught graduate students rather than those who taught undergraduate students, and between those who attended training for online teaching compared to those who had not. In addition to supporting diverse online students, this study has implications for online instructors, instructional designers, and administrators who provide support to integrate these strategies effectively.
Anesthetic efficacy of dexmedetomidine-ketamine in eastern box turtles (Terrapene carolina carolina) is enhanced with the addition of midazolam and when administered in the forelimb versus the hindlimb
Authors: Heniff Ashlyn C. , Petritz Olivia A. , Carpenter Rachel G. , Lewbart Gregory A. , Balko Julie. A. 
Published: December 2023

Abstract

OBJECTIVE
To compare dexmedetomidine-ketamine (DK; 0.1 and 10 mg/kg, respectively) with midazolam (M; 1.0 mg/kg) or 0.9% sodium chloride (S; 0.2 mL/kg) administered IM in the forelimb (F) or hindlimb (H) in eastern box turtles (Terrapene carolina carolina).

ANIMALS
20 clinically healthy, captive adult eastern box turtles.

METHODS
In a randomized, blinded, complete crossover study with 1-week washout periods, turtles were administered each of 3 treatments: F-DKS, F-DKM, or H-DKM. Palpebral reflex, muscle tone, and withdrawal responses were serially assessed and used to calculate cumulative sedation scores at each 5-minute time point. The ability to intubate was evaluated. At 60 minutes, atipamezole (1.0 mg/kg) and either flumazenil (F-DKM, H-DKM; 0.05 mg/kg) or 0.9% sodium chloride (F-DKS; 0.5 mL/kg) were administered IM.

RESULTS
All treatments resulted in clinically relevant anesthetic effects. F-DKM produced significantly higher sedation scores than H-DKM or F-DKS at all time points between 10 and 60 minutes (P < .05). Sedation score variability was observed with all treatments with significantly higher variability for H-DKM (P < .05). Intubation was successful in 32, 89, and 11% of turtles in F-DKS, F-DKM, and H-DKM, respectively. Median (range) recovery time was 10 (5–22), 16 (7–45), and 12 (4–28) minutes for F-DKS, F-DKM, and H-DKM, respectively.

CLINICAL RELEVANCE
In eastern box turtles, forelimb dexmedetomidine-ketamine resulted in clinically relevant anesthetic effects that were heightened with the addition of midazolam. Hindlimb administration of midazolam-dexmedetomidine-ketamine resulted in reduced and more variable anesthetic effects compared to forelimb administration, supporting a hepatic first-pass effect.
Safe gastric wall closure in dogs using a single-layer full-thickness simple continuous suture pattern
Authors: Velay Ludivine , Thibaud Jennyfer , Rousseau Khadija Serghini , Lhuillery Eloïse , Libermann Stéphane , Gautherot Audrey , Bonneau Lucie , Etchepareborde Sébastien 
Published: December 2023

Abstract

OBJECTIVE
To evaluate different suture patterns for gastrostomy closure, with a focus on major complications and survival time. We hypothesized that using a full-thickness single-layer simple continuous pattern would be as safe as the traditional double-layer pattern and would not be associated with more major complications. To our knowledge, this is the first study to compare the suture patterns used for gastric closure in clinical situations.

ANIMALS
60 dogs that underwent gastrostomy for foreign body removal, with 20 dogs in each group.

METHODS
Dogs treated with gastrotomy from January 1, 2018, to January 1, 2023, were randomly assigned to groups based on the suture pattern used at the gastrotomy site. Gastrotomies were closed with a double-layer inverting continuous pattern (DLI) in the DLI group. Gastrotomies were closed using a double-layer simple continuous pattern (DLS) in the DLS group. Gastrotomies were closed with a full-thickness single-layer simple continuous pattern (SLS) in the SLS group.

RESULTS
All dogs were discharged from hospitalization. The survival rate did not differ among the 3 groups 1 month postoperatively, and major complications were not observed.

CLINICAL RELEVANCE
Using a full-thickness single-layer pattern is a safe alternative for gastrotomy closure.