bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory action of resveratrol in the central nervous system in relation to glucose concentration - an in vitro study on a blood-brain barrier model
Authors: Komorowska Justyna , Watroba Mateusz , Bednarzak Małgorzata , Grabowska Anna D. , Szukiewicz Dariusz 
Published: January 2024

Abstract
Objective and Design: This study aimed to investigate the anti-inflammatory properties of resveratrol (RSV) on astrocyte cytokine profiles within the in vitro model of blood-brain barrier (BBB) under varying glucose concentrations (2.2, 5.0, and 25.0 mmol/L).
Material:The subjects comprised the in vitro co-cultures of endothelial cells and astrocytes within the BBB model with 0.4-µm-wide pores between them.
Treatment:RSV was administered at a dosage of 50 μM to the microvascular compartment (MC), and the duration of the intervention was 24 hours.
Methods: Cytokine levels (IL-1 α, IL-1 β, IL-2, IL-4, IL-6, IL-8) in the brain compartment (BC) were assessed using a Multi-Analyte ELISArray Kit before and after the addition of LPS and RSV. Statistical analysis was conducted to determine significance levels.
Results: RSV significantly reduced the concentration of all studied cytokines in the BC, regardless of glucose levels. The most substantial decrease occurred under normoglycemic conditions. The concentration of RSV in the BC was highest in normoglycemic conditions compared to hypo- and hyperglycemia.
Conclusions:Administration of RSV in the MC demonstrated anti-inflammatory effects within BC, particularly in normoglycemia-simulating conditions. Future in vivostudies, including animal and human research, are needed to explore the bioavailability of RSV within the CNS.
Integrated assessment of a coastal lagoon ecological status based on benthic macroinvertebrates
Authors: Boutahar Loubna , Maanan Mehdi , Bououarour Oussama , Kamcha Reda El , Maanan Mohamed , Bazairi Hocein 
Published: January 2024

Abstract
Coastal lagoons are considered as one of the most productive ecosystems worldwide but are also vulnerable to the growing human-made stressors. This study aimed at assessing, for the first time, the ecological status of the Oualidia lagoon (Atlantic coast of Morocco) using benthic macroinvertebrates as bioindicators. An integrative ecological monitoring approach based on spatial diversity patterns of species assemblages (examined using taxonomic indices, structural trophic guilds as indicators of the functional biodiversity, and marine biotic indices) in relation to sedimentary and hydrological descriptors was performed. Results showed that hydrodynamic conditions, represented by intra-lagoon currents and the watershed, govern the entire sediment distribution within the lagoon and establish a longitudinal downstream-upstream gradient and transverse right-left banks, which explained 66% of the total variation observed in benthic assemblage composition. Seagrass meadows affect positively the abundance of dominant species but do not support high diversity. Overall, macrozoobenthos spatial pattern consists in modification of the relative abundance of species, independently of species composition. The average score of the ecological classes obtained from five biotic indices (AMBI, BENTIX, H’, MAMBI and ITI) showed an acceptable status of the benthic assemblages. This integrated analysis resulted in a holistic view of the benthic-ecosystem that will serve in implementing an ecosystem-based approach to the management of the Oualidia lagoon.
Digital storytelling online: A case report exploring virtual design, implementation opportunities and challenges
Authors: Mansfield Elizabeth , Jalal Nafeesa , Sanderson Rani , Shetty Geeta , Hylton Andrea , D'Silva Chelsea 
Published: January 2024

Abstract
Background: Digital storytelling is an arts-informed approach that engages short, first-person videos, typically three to five minutes in length, to communicate a personal narrative. Prior to the pandemic, digital storytelling initiatives in health services research were often conducted during face-to-face workshops scheduled over multiple days. However, throughout the COVID-19 lockdowns where social distancing requirements needed to be maintained, many digital storytelling projects were adapted to online platforms.
Methods: As part of a research project aiming to explore the day surgery treatment and recovery experiences of women with breast cancer in Peel region, we decided to pivot our digital storytelling process to an online format. During the process, we observed that the online digital storytelling format had multiple opportunities and challenges to implementation.
Results: This paper outlines our promising practices and lessons learned when designing and implementing an online digital storytelling project including pre-production, production and post-production considerations.
Conclusions: We provide lessons learned for future teams intending to conduct an online digital storytelling project.
Low Temperature NO2 Gas Sensing by Delafossite-Structured AgFeO2 Nanograins
Authors: More Neha , Bhise Rahul , Zirpe Maheshwari , Padvi Mukesh , Thakur Jyotsna 
Published: January 2024

Abstract

Nitrogen Dioxide (NO2) gas monitoring has become increasingly important to ensure the safety of human lives and the environment. The present study investigates the potential of low-cost delafossite-structured AgFeO2 nanoparticles to detect NO2 gas at low temperature. Highly porous, grain-like AgFeO2 nanoparticles were prepared by simple co-precipitation method and characterized using XRD, FESEM-EDS, TEM and BET analysis.AgFeO2 nanograins synthesized by conventional method, demonstrated gas-sensing performance with respect to sensitivity (1.89%), short response (51s) and, selectivity at low temperature of 50 oC, towards 8 ppm NO2 gas.
Patient Perceptions of the Benefits of Physical Activity Throughout the Cancer Continuum in Cancer Survivor Populations
Authors: Dean Kristin , Stamp Elizabeth , Morris Mhairi 
Published: January 2024

Abstract
Purpose
Physical activity (PA) and exercise have multiple benefits throughout the cancer continuum, including alleviating treatment side effects, improving quality of life, and preventing secondary recurrence. Despite these benefits being well-documented, most cancer survivors do not meet the minimum exercise guidelines.
Method
To assess cancer survivors’ beliefs and experiences surrounding exercise during treatment, a 12-question survey was disseminated to a range of cancer survivors. Free-form comments were reviewed to identify common themes.
Results
Out of the 275 initial respondents, 198 male and female cancer survivors completed the questionnaire, upon which qualitative and quantitative analysis was conducted revealing a reduction in feelings of depression and anxiety in 83.36% of respondents. Physical barriers were the most common reported theme, followed by healthcare-related barriers due to lack of knowledge and guidance, with 99% of respondents agreeing a greater emphasis on this aspect is needed. Stretching/yoga-based activities were the most favoured type of exercise amongst respondents.
Conclusions
The findings presented herein comprehensively demonstrate the benefits of and barriers to participating in PA throughout the cancer continuum. Healthcare practitioners working with cancer survivors need to be cognisant of these barriers when designing interventions aimed at improving PA adherence.
Implications for Cancer Survivors: Individualised exercise programmes that consider all aspects of an individual’s cancer journey (cancer type, treatment modalities, etc.) may be able to correct the disconnect between knowledge of the benefits of PA and adherence to current guidelines amongst cancer survivors.
The ABCs of Russia's post-transition growth: What went wrong?
Authors: Ogloblin Constantin , Brock Gregory 
Published: January 2024

Abstract
The study uses industry-level data to examine the drivers of Russia’s economic growth in 2000–2008, when the average annual growth rate was 6.45%, in comparison with 2010–2016, when it fell to 1.75%. We apply the stochastic frontier method to quantify input-driven, technology-driven, and efficiency-driven growth. The influence of the world oil price on Russia’s growth is estimated from the perspective of its effects on both expansion of inputs (extensive growth) and production efficiency (intensive growth). The oil price movements affected capital and labor growth, but the government used a rent management system to mitigate these effects. As a result, the rate of extensive growth in 2000–2008, when the oil price was rising, was about the same (around 3%) as in 2010–2016 when the oil price was falling. The intensive (TFP-driven) growth rate fell from an average of 2.7% per year in 2000–2008 to − 1% in 2010–2016 due to a substantial decline in production efficiency during the latter period. Although the world price of oil could be partly responsible for this trend, we found the evolution of Russia’s economic system from generally market-oriented to largely controlled by kleptocracy to be the main factor behind it. Despite some changes in the economy’s industrial structure that occurred during both periods, the structural transformation had a negligible effect on growth.
NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10
Authors: Sun Huimin , Fu Meiling , Li Jinxin , Xuan Zuodong , Bai Yang , Zheng Zeyuan , Liu Yankuo , Zhang Zeyi , Xue Yi , Zheng Jianzhong , Zhong Min , Liu Bin , Du Yifan , Sui Suiyuan , Zhang Lei 
Published: January 2024

Abstract

Prostate cancer (PCa) is one of the most common male genitourinary system malignancies. The reasons for the poor therapeutic efficacy of anti-PD-L1 immune checkpoint inhibitor therapy in PCa, despite its significant benefits in other cancers, are unclear. NDR1 plays an important role in innate immunity, but its role in tumor immunity and immunotherapy has not been investigated. The role of NDR1 in the immune microenvironment of PCa and the related mechanisms are unknown. Here, we found a positive correlation between NDR1 and PD-L1 expression in PCa. NDR1 significantly inhibited CD8 + T cell infiltration and function and promoted PCa immune escape. More importantly, NDR1 inhibition significantly enhanced CD8 + T cell activation, which enhanced the therapeutic effect of anti-PD-L1. Mechanistic studies revealed that NDR1 inhibits ubiquitination-mediated PD-L1 degradation via the deubiquitinase USP10, upregulates PD-L1, and promotes PCa immune escape. Thus, our study suggests a unique PD-L1 regulatory mechanism underlying PCa immunotherapy failure. The significance of NDR1 in PCa immune escape and its mechanism of action were clarified, and combined NDR1/PD-L1 inhibition was suggested as an approach to boost PCa immunotherapy effectiveness.
Egalitarian preferences in young children depend on the sexes of the interacting partners
Authors: Wingerden Marijn van , Oberliessen Lina , Kalenscher Tobias 
Published: January 2024

Abstract

In decisions between equal and unequal resource distributions, women are often believed to be more prosocial than men. Previous research showed that fairness attitudes develop in childhood, but their – possibly gendered, developmental trajectory remains unclear. We hypothesized that gendered fairness attitudes might depend not only on the sex of the actor, but also on that of the interaction partner. To examine this, we tested 332 three to eight-year-old children in a paired resource allocation task, with both boys and girls acting as allocators and recipients. We found sex effects that gradually emerged during childhood: girls more than boys aimed to reduce advantageous inequality, and allocators of both sexes were more averse against male recipients being better off. Notably, girls exhibited an envy bias, i.e., they tolerated less when the resource allocation was in favour of boys than if it favoured other girls. We also observed a sex spite gap: unlike girls, even the oldest boys treated other boys with spite, i.e., they valued unfair distributions in their own favour over equal outcome alternatives. This pattern hints at contextualized gendered fairness preferences that evolve with age and are, next to other factors, possibly sharpened by same- and cross-sex past interaction experiences.
The uniform structure of g⊗4
Authors: Avetisyan Maneh , Isaev Alexey P. , Krivonos Sergey , Mkrtchyan Ruben 
Published: January 2024

Abstract
We obtain a uniform decomposition into Casimir eigenspaces (most of which are irreducible) of the fourth power of the adjoint representation g⊗4 for all simple Lie algebras. We present universal, in Vogel’s sense, formulae for the dimensions and split Casimir operator’s eigenvalues of all terms in this decomposition.We assume that a similar uniform decomposition into Casimir eigenspaces with universal dimension formulae exists for an arbitrary power of the adjoint representations.
Discovery of a deadly species of box jellyfish Chironex indrasaksajiae in Palk Bay, southeast coast of India
Authors: Saravanan R. , Ranjith L. , Thirumalaiselvan S. , Sadiq I. Syed , Vinod K. 
Published: January 2024

Abstract
The current study documents the occurrence of Chironex indrasaksajia, a potentially deadly box jellyfish species, in Palk Bay. This is the first time a species of Chironex has been discovered along the Indian coast, and up to now, no box jellyfish from the genus Chironex has been documented. As a result, fishermen need to be aware of how to manage stings in an emergency and prevent severe envenomation. Further study on the species distribution around Indian coastal water is required to understand its distribution. This study confirms the westward distribution range of this species from its previously reported area Gulf of Thailand. Among the three species of Chironex, this is the first species reported from Indian waters.
Research on Optimization and dispatch of Non cooperative Games among Four Parties in the Comprehensive Energy Market under the Mapping of Stepped Carbon Tax
Authors: Zhang Shuaibo , He Fei 
Published: January 2024

Abstract

Within the context of the global "dual-carbon" policy, the study explores the low-carbon energy transactions among diverse entities in the comprehensive energy market and the constraints imposed by the design of tiered carbon tax policies. This has emerged as a research hotspot in the field of low-carbon economic dispatch. The paper comprehensively examines the coupled relationship between the energy consumption and corresponding carbon emission factors among four entities: microgrid energy operators, flexible shared energy storage, electric to heat transfer operator, and community aggregator. It maps the corresponding energy prices into the interests of a non-cooperative game among entities, thereby guiding each entity to achieve a balance between carbon emissions and economic costs. The paper utilizes an enhanced genetic-particle swarm hybrid algorithm for solving and validates the effectiveness of the dispatch strategy by analyzing the marginal and cumulative effects generated by the design of tiered carbon tax policies. The findings indicate that under continuous tiered carbon tax mapping, the formulation strategy of electricity and heat prices has been further optimized, balancing the interests of the four entities, and effectively enhancing the integration of new energy while reducing the output of fossil energy units.
Relationship Between Globalization and the Forest Area Footprint: An Ardl Approach for Brazil
Authors: Rocha Moisés S. , Ferreira Lindomayara F. , Faria Weslem R. 
Published: January 2024

Abstract
This article aims to identify the relationship between globalization and the forest product and carbon Footprint, used as proxies for the Ecological Footprint of the forestry area, for the Brazilian context. Specifically, we verify their relationships between the main dimensions of globalization (from the KOF Globalization Index). To determine the short-run and long-run relationships between the variables, the autoregressive distributed lag (ARDL) approach of time series data between 1989 and 2018 is used. The main results suggest that the general globalization index does not have a significant influence on the Ecological Footprint of the forest area. However, the dimensions of disaggregated globalization – economic, social, and political – present different relationships with the Ecological Footprint of the forest area in the short and long term. In conclusion, the results provide important evidence for developing policies that encourage society to adopt trends and habits of consumption, production, and cultural aspects to mitigate the degradation of forests and air and water pollution.
Quality of Child Care Environment among the Parents of Children with Disabilities, In the case of Khovd Province, Mongolia
Authors: Gan-Yadam Amarsanaa 
Published: January 2024

Abstract
The main purpose of this study was to assess the quality of the childcare environment among parents of children with disabilities. The study also looks at the factors that influence the childcare environment and assesses the validity of using the Index of Child Care Environment in the context of Mongolia, particularly for children with disabilities. A total of 84 parents with disabled children were surveyed based on their self-reported responses, and the child care environment was assessed using the Index of Child Care Environment. Simple descriptive analysis, the X2 test, and logistic regression analyses were used for quantitative data analysis. All the statistical analyses were performed with IBM SPSS version 27. The qualitative methods were used to obtain deeper insights into parents’ perceptions and attitudes in relation to the study subjects. Content analysis was used for qualitative data analysis. The study results revealed that the Index of Child Care Environment can be used to assess the quality of the child care environment in Mongolia. Multiple logistic regression analysis revealed that parents’ education, employment status, and accommodation type were significantly related to the child care environment. On the other hand, the children’s age was significantly related to going shopping with parents and meeting children of similar ages. The children’s gender was related to reading books with their parents. The study also revealed that the quality of the child care environment was not sufficient for the selected parents. Further studies with more diverse settings are required to identify and assess child care environments in Mongolia to identify local-based strategies and models for caring for children in a local culture-based context.
Applying Knowledge Graphs for Personalized Product Recommendation in E-commerce According to Consumers Interests
Authors: tang chuming , tao peng , li yan 
Published: January 2024

Abstract

Large-scale e-commerce platforms often encompass various recommendation scenarios to cater to the diverse needs of different consumers. In recent years, the application of knowledge graph-based multi-domain recommendation (MDR) has drawn increasing attention of researchers. The state-of-the-art MDR methods have typically shared structures, shared parameters, and domain-specific components with specific parameters. However, due to the variations in data distributions across different domains, shared parameters often suffer from domain conflicts during the training process, while domain-specific parameters are prone to overfitting in sparse data domains. To address these problems, we have proposed the GDKG2D (GDKG + DN + DR) model for multi-domain recommendation of products. An unsupervised learning approach is firstly employed to construct a generalized domain knowledge graph (GDKG), in which a Local Weighted Smoothing (LWS) scheme according to consumer interests has been designed to encode the nodes. Node embeddings is then used in LWS to train encoders for consumers in the consumer-product bipartite graph. Subsequently, a Domain Negotiation (DN) strategy is employed to alleviate domain conflicts. Domain Regularization (DR) is applied finally in training in other domains to enhance the generalization performance of specific parameters. After evaluating on the product recommendation datasets from Amazon and Taobao, the GDKG2D model demonstrates significant advantages over conventional MDR methods. It exhibits superior performance, particularly in terms of AUC scores.
Anti-diabetic effect of di-caffeoylquinic acid is associated with the modulation of gut microbiota and bile acid metabolism
Authors: Huang Yujie , Xu Weiqi , Chen Guijie , Sun Yi , Zeng Xiaoxiong 
Published: January 2024

Abstract

Background The human gut microbiome plays a critical role in both health and disease. A classic example of host-gut microbial co-metabolism involves bile acids, which biosynthesis in liver are excreted into the intestine where they are deconjugated and transformed by the gut microbiota, this process, in turn, activates signaling pathways, influencing host glycolipid and energy metabolism.Ilextea exhibits properties that alleviate disruptions in lipid metabolism and inflammation by modulating the gut microbiota, yet the underlying mechanism remains unelucidated. DiCQAs is one of the most active and abundant polyphenolic pigments inIlextea. Here, we investigated diCQAs regulate diabetes through the BA-related pathway, using HFD + STZ-induced diabetic mice model and long-term mice group to exclude direct stimulatory effects, and studied gut microbiota structure and functions in mice. Results Here, we show that diCQAs alleviating symptoms of diabetic mice by alters gut microbiota carrying the BSH gene which associated with obesity and diabetes mellitus. DiCQAs protecting the intestinal barrier while increased enterohepatic circulation conjugated BAs, inhibited the FXR-FGF15 signaling axis in the ileum decreased hepatic FGFR4 protein expression, increased bile acid synthesis in liver, increased BA efflux to reduces hepatic BA stasis, decreased hepatic and plasma cholesterol levels. Moreover, diCQAs induce an upregulation of glucolipid metabolism-related proteins in the liver and muscle (AKT/GSK3β, AMPK), ultimately alleviating hyperglycemia. Additionally, they reduce inflammation by down-regulating the MAPK signaling pathway in the diabetic group. Conclusions Our findings provide insights into the mechanisms underlying the anti-diabetic effects of ilex tea. They suggest that reducing gut microbiota (specificallyAcetatifactor sp011959105andAcetatifactor muris) carrying the BSH gene could potentially serve as an anti-diabetic therapy by decreasing FXR-FGF15 signaling.
Prevalence and Predictors of Depression and Anxiety among Multidrug-Resistant Tuberculosis Patients and Their Household Contacts in Gujarat, India
Authors: M Yogesh , Parmar Dipesh V , Patel Nirmalkumar Shaileshbhai 
Published: January 2024

Abstract
Background
Mental health comorbidities worsen multidrug-resistant tuberculosis (MDR-TB) outcomes. Patients who have household contacts are also at high risk. We aimed to determine the prevalence, correlates, and predictors of depression and anxiety among MDR-TB-affected families.
Methods
A cross-sectional analytical study was conducted among 400 MDR-TB patients and 400 household contacts in Gujarat. The validated scales measured depression (PHQ-9), anxiety (HAM-A), perceived stigma (CIASS), and social support (MSPSS). Multivariate logistic regression was used to identify associated factors.
Results
The prevalence of depression and anxiety symptoms was 150 (37.5%) and 180 (45%) among patients and 80 (20%) and 100 (25%) among contacts, respectively. Stigma (OR 3.2, 95% CI 1.1–5.3), mental illness history (OR 2.1, 95% CI 1.3–3.5), and disease severity (OR 1.8, 95% CI 1.5–2.2) independently predicted greater odds of depression. Similar associations were found for anxiety.
Conclusion
High mental health comorbidity among MDR-TB patients and interconnectivity with household contacts indicate an urgent need to integrate emotional-physical wellbeing initiatives through decentralized patient-centric care models. Thus, psychosocial support and stigma mitigation should complement conventional services.