bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Digital Marketing dan Customer Relationship Marketing Terhadap Minat Berkunjung di Saung Angklung Udjo Bandung
Authors: Mulyana Hadi 
Published: October 2023

This research is aimed to discover the Digital Marketing and Customer Relationship Marketing of Visit Interest at Saung Angklung Udjo Bandung. It applies quantitative methode with the use of descriptive and verificative analysis as wel as the path linear regression analysis technique. The variable that has been used in the research is the digital marketing (X1), customer reletionship (X2) variable itself that hypothetically will lead to a positive and significant effect on the visit interest. The sample and population of research are 100 respondents off all tourist who visit in Saung Angklung Udjo Bandung. The testing instrument result shows that the hypothetic statement above is valid 0,30 and also reliable because it’s over 0,70. The descriptive analysis of digital (X1) variable, which is on the average of 4,0 falls into “good category”, the descriptive analysis customer relationship marketing (X2) variable, which is on average of 4,0 falls into “good category”. Meanwhile visit interest (Y) variable which is on the average of 4,1, fall into “good category”. The result of verificative analysis depects tcount 2,577 (X1), is higher than ttable which is 1,6608 and Fcount is inferred 32,623 higher than Ftable which is 3,94 so overall those variable show positive and significant result partially and simultaneously. The total of Digital Marketing and Customer Relationship Marketing of Visit Interest (R2) or the coefficient of determination is as high as 0,402 (40,2%), with the rest of 0,598 (59,8%) is affected by other factors that are not studied and covered by this research.
Immunosurveillance in clinical cancer management
Authors: Kroemer Guido , Chan Timothy A. , Eggermont Alexander M. M. , Galluzzi Lorenzo 
Published: October 2023

AbstractThe progression of cancer involves a critical step in which malignant cells escape from control by the immune system. Antineoplastic agents are particularly efficient when they succeed in restoring such control (immunosurveillance) or at least establish an equilibrium state that slows down disease progression. This is true not only for immunotherapies, such as immune checkpoint inhibitors (ICIs), but also for conventional chemotherapy, targeted anticancer agents, and radiation therapy. Thus, therapeutics that stress and kill cancer cells while provoking a tumor‐targeting immune response, referred to as immunogenic cell death, are particularly useful in combination with ICIs. Modern oncology regimens are increasingly using such combinations, which are referred to as chemoimmunotherapy, as well as combinations of multiple ICIs. However, the latter are generally associated with severe side effects compared with single‐agent ICIs. Of note, the success of these combinatorial strategies against locally advanced or metastatic cancers is now spurring successful attempts to move them past the postoperative (adjuvant) setting to the preoperative (neoadjuvant) setting, even for patients with operable cancers. Here, the authors critically discuss the importance of immunosurveillance in modern clinical cancer management.
Video-Assisted Thoracoscopic Surgery (VATS) in the Treatment of Pulmonary Bulla
Authors: Rahman S M Tajdit , Rahman Mia Md Mofizur , Hossain Mosharraf , Islam Shakil Kazi Saiful , Kibria Anwarul Anam , Biswas Manabendra , Rahim Abdur , Hossain Mobarak , Islam Md Nazmul , Razzaque A K M Razzaque 
Published: October 2023

Introduction: Video-assisted thoracoscopic surgery (VATS) has been widely applied for the treatment of intrathoracic diseases, including bullous lung disease. VATS has been evaluated to replace thoracotomy for various lung resection surgeries. This study aims to determine the efficacy, safety, and outcome VATS for bullectomy.
Method: This retrospective study was performed from January 2021 to December 2022 in the department of Thoracic Surgery at National Institute of Diseases of the Chest & Hospital, Dhaka and Green Life Hospital, Dhaka. We reviewed all the patients who underwent bullectomy through VATS within this period. The demographic and operative variables were collected. The safety and efficacy of the procedure in terms of postoperative complications and change in lung function after bullectomy was analysed.
Result: Forty patients underwent elective VATS bullectomy due either to giant bulla or pneumothorax. Among them, 36 were male with mean age 47.4 years (range 20-65 years). There was significant improvement in lung function following bullectomy. Approximately one third patients (32.5%) developed postoperative complications, majority having air leak. There was no postoperative mortality within 30 days.
Conclusion: VATS resection is a safe and effective treatment for bullous lung disease with significant improvement in symptoms and lung function following surgery.
J Bangladesh Coll Phys Surg 2023; 41(4): 287-293
PROGRAM PEMBERDAYAAN MASYARAKAT MELALUI PENGELOLAAN USAHA RUMAHAN (Studi pada Aktifitas Ibu-Ibu Rumah Tangga Di Desa Wisata Dewi Sri Di Kecamatan Jabung Kabupaten Malang)
Authors: Sigit Wahyudi  , Abdul Wahid Mahsuni  , Sulafah Fathin Khannanah  
Published: October 2023

Salah satunya kalangan wanita bisa tingkatkan keselamatan keluarganya dengan melaksanakan aktivitas upaya produktif rumah tangga, dengan memproduksi serta menjual makan rumahan,agar meningkatkan perekonomian. Kesempatan bidang usaha hidangan rumahan tengah terbuka karna hidangan rumahan ialah hidangan penting penduduk, dimana hidangan itu diperlukan tiap saat. Bidang usaha santapan rumahan tidak sangat susah dicoba, sebab ibu- ibu rumah tangga bisa melaksanakan aktivitas pembuatan ataupun memasak sekalian buat keluarganya serta materi bakunya gampang didapat di pasar- pasar konvensional. Aktivitas dedikasi warga ini, bermaksud buat ( 1) menggunakan kemampuan ibu rumah tangga guna mendapatkan pemasukan tambahan untuk menopang ekonomi keluarga.( 2) Tingkatkan perekonomian atau keselamatan keluarga. Luaran aktivitas dedikasi warga ini merupakan Ibu- ibu Rumah Tangga Desa Sidorejo, Kabupaten Malang bisa membenarkan manajemen upaya serta mencari kesempatan upaya yang bisa dicoba dari rumah tanpa wajib meninggalkan keluarga.
Kata Kunci: Pemberdayaan, Ibu Rumah Tangga, Upaya Rumahan, Ekonomi Keluarga

One of them is that women can increase the safety of their families by carrying out household productive activities, by producing and selling home-cooked meals, in order to boost the economy. The opportunity for the home-cooked meal business is opening up because home-cooked meals are the main dish of the people, where these dishes are needed at any time. The home-based food business is not too difficult to try, because housewives can carry out manufacturing or cooking activities at the same time for their families and the raw materials are easily available in conventional markets. This community dedication activity intends to (1) use the ability of housewives to get additional income to support the family economy. (2) Improve the economy or family safety. The output of this community dedication activity is that the housewives of Sidorejo Village, Malang Regency can justify business management and look for business opportunities that can be tried from home without having to leave the family.
Keywords: Empowerment, Housewife, Home Effort, Family Economy
An Analysis on Indonesian—English Abstract Translation to Enhance Multicultural Language in Accounting Department, State Polytechnic of Malang
Authors: Maulidiyah Fitrotul 
Published: October 2023

Thesis writing is one compulsory subject which must be completed by students at State Polytechnic of Malang particularly in Accounting Department. Moreover, an abstract is an inseparable part of thesis which must be written by all students. The abstracts must be written both in Indonesian and English. Students have to translate their Indonesian abstract into English. From the preliminary study, it was found out that students have many difficulties in translating their thesis abstract from Indonesian into English. Hence, this research seeks to investigate what type of errors committed by the students during the process of English abstract writing. A descriptive qualitative design was used in this research. Documents in the form of 25 abstracts were used in the data analysis. The results showed that during the process of English abstract writing completion, students tend to have problems in abstract translation, grammar, vocabularies, sentence structures and writing mechanics. Detailed results were presented and discussed in the coming sections, followed by recommendations for further research.
Keywords: abstract writing, translation, machine translation, Google Translate
Bone density optimized pedicle screw insertion
Authors: Tsagkaris Christos , Calek Anna-Katharina , Fasser Marie-Rosa , Spirig José Miguel , Caprara Sebastiano , Farshad Mazda , Widmer Jonas 
Published: October 2023

Background: Spinal fusion is the most common surgical treatment for the management of degenerative spinal disease. However, complications such as screw loosening lead to painful pseudoarthrosis, and are a common reason for revision. Optimization of screw trajectories to increase implant resistance to mechanical loading is essential. A recent optimization method has shown potential for determining optimal screw position and size based on areas of high bone elastic modulus (E-modulus).Aim: The aim of this biomechanical study was to verify the optimization algorithm for pedicle screw placement in a cadaveric study and to quantify the effect of optimization. The pull-out strength of pedicle screws with an optimized trajectory was compared to that of a traditional trajectory.Methods: Twenty-five lumbar vertebrae were instrumented with pedicle screws (on one side, the pedicle screws were inserted in the traditional way, on the other side, the screws were inserted using an optimized trajectory).Results: An improvement in pull-out strength and pull-out strain energy of the optimized screw trajectory compared to the traditional screw trajectory was only observed for E-modulus values greater than 3500 MPa cm3. For values of 3500 MPa cm3 or less, optimization showed no clear benefit. The median screw length of the optimized pedicle screws was significantly smaller than the median screw length of the traditionally inserted pedicle screws, p &lt; 0.001.Discussion: Optimization of the pedicle screw trajectory is feasible, but seems to apply only to vertebrae with very high E-modulus values. This is likely because screw trajectory optimization resulted in a reduction in screw length and therefore a reduction in the implant-bone interface. Future efforts to predict the optimal pedicle screw trajectory should include screw length as a critical component of potential stability.
Physicochemical properties and cell proliferation and adhesive bioactivity of collagen-hyaluronate composite gradient membrane
Authors: Li Zhaoxuan , Song Xue , Fan Yan , Bao Yuming , Hou Hu 
Published: October 2023

Membrane materials were widely used in guided tissue regeneration (GTR) to prevent fibroblast invasion and form a confined area for preferentially growing of osteoblast. A novel collagen-hyaluronate composite gradient membrane was prepared by Tilapia (Oreochromis mossambicus) skin collagen and sodium hyaluronate for potential GTR applications and their bioactivities were investigated by cellular viability. SEM results indicated the membrane showed a dense outer and a porous inner surface for effectively guiding the growth of bone tissue. Physicochemical and biosafety experiments showed the tensile strength of membrane was 466.57 ± 44.31 KPa and contact angle was 74.11°, and the membrane showed perfect biocompatibility and cytocompatibility as well, which met the requirements of GTR material. Cell morphology revealed that the membrane could facilitate the adherence and proliferation of fibroblast and osteoblast. The results of qRT-PCR and ELISA demonstrated that the membrane could effectively activate TGF-β/Smad pathway in fibroblast, and promote the expressions of TGF-β1, FN1 and VEGF. Remarkably, RUNX2 was stimulated in BMP2 pathway by the membrane to regulate osteoblast differentiation. In summary, the collagen-hyaluronate composite gradient membrane not only fulfills the prerequisites for use as a GTR material but also demonstrates substantial potential for practical applications in the field.
Factors associated with chronic kidney disease in patients with diabetes in French Guiana
Authors: Sacareau Christopher , Nacher Mathieu , Drak Alsibai Kinan , Ntoutoum Andre , Adenis Antoine , Hounnou Marianne , Liebart Marion , Cardoso Clara Salasar , Aurelus Jean-Markens , Demar Magalie , Casse Olivier , Amokrane Samia , Carod Jean-François , Hafsi Nezha , Sabbah Nadia 
Published: October 2023

IntroductionWith over half of the population living under the poverty threshold, the social and health context in French Guiana is more difficult than in mainland France. The prevalence of diabetes is twice as great and end-stage renal failure is 45% higher than in mainland France.ObjectiveOur objective was to describe the profile of diabetic patients with chronic kidney disease in French Guiana and search for possible risk factors.MethodWe conducted a multicenter cross-sectional observational study based on the CODIAM cohort (Cohort of Diabetes in French Amazonia). We analyzed 1,287 patients followed up between May 2019 and June 2021 at Cayenne Hospital, Saint Laurent Hospital, and delocalized health centers.ResultsIn our cohort, chronic kidney disease was present after an average of 12 years of diabetes. Compared with the French population, 41% of diabetic patients had chronic kidney disease (i.e., 12% more), and had an average age of 56 years (i.e., 10 years younger). Forty-eight per cent of these patients were obese (i.e., 7% more). Seventy-four per cent of patients were precarious and 45% were foreigners but neither was associated with chronic kidney disease, contrary to countries where the health system is not universal.ConclusionScreening of patients with chronic kidney disease among diabetics in French Guiana remains a real challenge. Patients were younger and more obese than in other French territories. In this cohort, precariousness and immigration were not associated with the presence of chronic kidney disease. However, particular attention should be paid to hypertensive patients and those over 65 years of age, which are, with diabetes itself, the two most obvious risk factors for developing chronic kidney disease among diabetic patients in our territory.
Clinical manifestations of human leptospirosis: bacteria matter
Authors: Rajaonarivelo Jeanne Arline , Desmoulin Anissa , Maillard Olivier , Collet Louis , Baudino Fiona , Jaffar-Bandjee Marie-Christine , Blondé Renaud , Raffray Loïc , Tortosa Pablo 
Published: October 2023

IntroductionA high incidence of human leptospirosis is recorded on Mayotte, an oceanic island located in southwestern Indian Ocean, but the severity of the disease appears relatively mild in terms of mortality rate and admission to the intensive care unit. It has been proposed that mild leptospirosis may result from a limited virulence of some of the occurring Leptospira species to which the population is exposed.MethodsClinical and biological data of patients admitted to the Centre Hospitalier de Mayotte were collected and the infecting Leptospira species were determined through molecular typing.ResultsLeptospira interrogans was detected in the minority of admitted patients but most of these patients suffered from severe forms, with 50% admitted to intensive care unit and suffering from organ failures. Nineteen percent of patients infected with Leptospira borgpetersenii were admitted to the intensive care, with 13% displaying organ failures, and one patient died. Leptospira mayottensis was found in 28% of the patients and not a single severe case was observed.DiscussionThe distribution of Leptospira species in patients was not different from that reported 10-15 years ago and bacterial genotypes were very closely related to those previously reported. These results highlight the importance of the diversity of pathogenic Leptospira circulating on Mayotte island and are in keeping with distinct outcome of the disease depending on the infecting Leptospira. Altogether, presented data support that the infecting Leptospira species is an important driver of disease severity in humans.
Diagnostic value of inflammatory indicators for surgical site infection in patients with breast cancer
Authors: Li Dongmei , Ding Shanshan , Li Jie , Liao Xianglu , Ru Kun , Liu Lisheng , Shang Wenjing 
Published: October 2023

BackgroundBreast cancer is the most commonly diagnostic cancer in women worldwide. The main treatment for these patients is surgery. However, there is a high incidence of surgical site infection (SSI) in breast cancer patients. The aim of this study was to identify effective infection-related diagnostic markers for timely diagnosis and treatment of SSI.MethodsThis retrospective study included 263 breast cancer patients who were treated between July 2018 and March 2023 at the Shandong Cancer Hospital and Institute. We analyzed differences between the SSI group and control group and differences before and during infection in the SSI group. Finally, we tested the distribution of pathogenic microorganisms and their susceptibility to antibiotics.ResultsCompared with preoperative inflammatory indicators, white blood cells (WBC), neutrophils (NEU), absolute neutrophil count to the absolute lymphocyte count (NLR), D2 polymers (D-Dimer) and fibrinogen (FIB) were significantly increased, while lymphocytes (LYM), albumin (ALB) and prealbumin (PA) were significantly decreased in the SSI group. Compared with uninfected patients, WBC, NEU, NLR and FIB were significantly increased, ALB and PA were significantly decreased in SSI patients, while LYM and D-Dimer did not differ significantly. The distribution of infection bacteria in SSI patients showed that the proportion of patients with Staphylococcus aureus infection was as high as 70.41%; of those patients, 19.33% had methicillin-resistant Staphylococcus aureus (MRSA) infection. The area under the curves (AUCs) of the receiver operating curves (ROCs) for WBC, NEU, NLR, FIB, ALB and PA were 0.807, 0.811, 0.730, 0.705, 0.663 and 0.796, respectively. The AUCs for other inflammatory indicators were not statistically significant. There was no significant difference in antibiotic resistance for Staphylococcus aureus when compared to that of gram-positive bacteria. The resistance of gram-positive bacteria to ceftriaxone (CRO), cefoxitin (FOX), chloramphenicol (CHL), minocycline (MNO) and tetracycline (TCY) was lower than that of gram-negative bacteria, while the resistance to gentamicin (GEN) was higher.ConclusionThis study demonstrated that WBC, NEU, NLR, FIB and PA have good predictive value for identifying patients at risk of SSI. The cut-off values of inflammatory indicators can be helpful in the prevention and diagnosis of SSI.
Physician experience with once-weekly somatrogon versus once-daily rhGH regimen in pediatric patients with growth hormone deficiency: a cross-sectional survey of physicians from the global phase 3 study
Authors: Gomez Roy , Lamoureux Roger , Turner-Bowker Diane M. , Loftus Jane , Maghnie Mohamad , Miller Bradley S. , Polak Michel , Yaworsky Andrew 
Published: October 2023

IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing. We describe physicians’ preference for, experiences, and satisfaction with once-weekly somatrogon vs once-daily rhGH.MethodsEnglish-speaking investigators from somatrogon’s global phase III study (NCT02968004) with prior experience using once-daily rhGH were included. Participants answered an online survey containing 14 closed- and open-ended items.ResultsTwenty-four pediatric endocrinologists (41.7% men; 79.2% practiced at public/private hospitals) from 12 countries with 25.8 ± 12.0 years’ experience treating pGHD completed the survey. In terms of the time and effort required to explain device instructions, injection regimen, procedure for missed injection, and address patients’/caregivers’ concerns, a similar proportion of physicians chose once-weekly somatrogon and once-daily rhGH; 62.5% physicians indicated that once-daily rhGH required greater effort to monitor adherence. Overall, 75% preferred once-weekly somatrogon over once-daily rhGH, 79.2% considered once-weekly somatrogon to be more convenient and less burdensome, and 83.3% were likely to prescribe somatrogon in the future. Overall, 50% felt that once-weekly somatrogon was more beneficial to patients, while 50% chose “No difference”. Most physicians (62.5%) felt both regimens were equally likely to support positive long-term growth outcomes and reduce healthcare utilization. More physicians were “very satisfied” with once-weekly somatrogon (62.5%) than with once-daily rhGH (16.7%). Reduced injection frequency, patient and caregiver burden, increased convenience, and improved adherence were reasons for these choices.ConclusionPhysicians had a positive experience with, and perception of, treating pGHD with once-weekly somatrogon.
Deep neural network for discovering metabolism-related biomarkers for lung adenocarcinoma
Authors: Fu Lei , Li Manshi , Lv Junjie , Yang Chengcheng , Zhang Zihan , Qin Shimei , Li Wan , Wang Xinyan , Chen Lina 
Published: October 2023

IntroductionLung cancer is a major cause of illness and death worldwide. Lung adenocarcinoma (LUAD) is its most common subtype. Metabolite-mRNA interactions play a crucial role in cancer metabolism. Thus, metabolism-related mRNAs are potential targets for cancer therapy.MethodsThis study constructed a network of metabolite-mRNA interactions (MMIs) using four databases. We retrieved mRNAs from the Tumor Genome Atlas (TCGA)-LUAD cohort showing significant expressional changes between tumor and non-tumor tissues and identified metabolism-related differential expression (DE) mRNAs among the MMIs. Candidate mRNAs showing significant contributions to the deep neural network (DNN) model were mined. Using MMIs and the results of function analysis, we created a subnetwork comprising candidate mRNAs and metabolites.ResultsFinally, 10 biomarkers were obtained after survival analysis and validation. Their good prognostic value in LUAD was validated in independent datasets. Their effectiveness was confirmed in the TCGA and an independent Clinical Proteomic Tumor Analysis Consortium (CPTAC) dataset by comparison with traditional machine-learning models.ConclusionTo summarize, 10 metabolism-related biomarkers were identified, and their prognostic value was confirmed successfully through the MMI network and the DNN model. Our strategy bears implications to pave the way for investigating metabolic biomarkers in other cancers.