bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of total glucosides of paeony on Chinese patients with systemic lupus erythematosus: a propensity-matched study
Authors: Li Qi , Yu Honghong , Yu fangyuan , Jin Ziyi , Geng Linyu , Feng Xuebing 
Published: October 2023

Abstract

Background To evaluate the real-world efficacy of total peony glycoside (TGP) treatment in patients with systemic lupus erythematosus (SLE). Methods A retrospective cohort analysis was conducted to evaluate the efficacy of TGP (administered for a minimum of 3 months) in SLE patients hospitalized to Nanjing Drum Tower Hospital between 2009 and 2021, using propensity score matching method. A total of 244 patients were included, of which differences in variables between the TGP-treated and non-TGP-treated groups were compared. To minimize the effect of confounding factors, multivariate logistic regression analysis was applied. Results Baseline variables were similar between the TGP and non-TGP groups, except for lower rates of cyclophosphamide and tripterygium glycoside administration in the TGP group. The median follow-up times for the two groups were 28.9 and 24.8 months, respectively. Compared with the control group, TGP treatment resulted in significantly improved musculoskeletal and mucocutaneous involvement. Meanwhile, patients in the TGP group exhibited elevated serum albumin levels and reduced total bile acid levels even after adjustment (OR = 2.43 and 2.44, p < 0.01). Conclusion TGP has shown potential beneficial in certain SLE patients, particularly those with musculoskeletal and mucocutaneous manifestations, as well as individuals liver dysfunction. Trial registration The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Nanjing Drum Tower Hospital (No. 2022-220-02).
Comparative Investigation of Hellenistic Period Fortification Structures in Ayasuluk Hill and Şirince Valley
Authors: NOBERİ Cansu , BARANAYDIN Fırat 
Published: October 2023

Abstract
During the Archaic and Classical periods, the acropolis of the city, which grew around Artemision and towards Mount Pion, was presumably Ayasuluk. After the Persian domination, Hellenistic activity continued on the Ayasuluk hill for a while. Afterwards, the city was moved by Lysimakhos between the mountains of Pion and Koressos. Pion and Koressos which dominate almost all the angles seen by Ayasuluk. However, not a single point is within the field of view of these two hills. The valley of Şirince, which was the bed of a large river in geologic periods to the east of Ayasuluk Hill, is only within the field of view of Ayasuluk Hill. This study, which examines the connection between the Hellenistic period fortification structures of Ayasuluk Hill and Şirince Valley, which constitute the subject of this study, firstly dates these two fortification structures by using archaeological methods. Then, it makes assertions on their construction techniques and material supply. With the help of different disciplines, samples taken from different parts of two regions are examined by using SEM and XRD analyzes. According to the analysis results, it has been proved that the building materials used in Ayasuluk Hill and Şirince Valley are similar.
Fabrication and Evaluation of Gallic Acid-encapsulated Curdlan Gum Nanoparticles for Effective Treatment of Breast Cancer
Authors: Pandi Ezhilarasi , Proskhan Bazeera Ferdhous , Kunjiappan Selvaraj , Sundar Krishnan , Balakrishnan Vanavil 
Published: October 2023

Abstract

Curdlan gum (CG) is a β-(1→3)-linked glucan insoluble exopolysaccharide produced by marine bacteriaEnterobacter cloacaesubsp.dissolvensRSW2n. In this study, CG was used to fabricate gallic acid-encapsulated curdlan gum nanoparticles (GA-CG NPs) for effectively delivering the drug into breast cancer cells (MCF-7) using glutaraldehyde as the crosslinking agent and a modified desolvation method was adopted. The fabricated GA-CG NPs were characterized by UV-visible spectra, FT-IR, XRD, particle size analyzer and HR-TEM. The stability of GA-CG NPs was evaluated at various pH and simulated body fluids.In vitrodrug release and its kinetics were examined through the dissolution mechanism using mathematical prediction models. The antioxidant and cytotoxic potential of GA-CG NPs were evaluated throughin vitroassays. The IC50of GA-CG NPs against MCF-7 cells was found to be 16.75 µg × mL− 1. The induction of apoptosis in MCF-7 cells was confirmed through flow cytometry. Nuclei condensation, loss of mitochondrial membrane potential, and deformed cell membranes were visualized by staining. Curdlan gum effectively controls the release of gallic acid as the gel matrix slowly degrades and releases the encapsulated gallic acid. Hence, the curdlan gum produced byE. cloacaecould be considered as promising candidate for drug delivery application for degenerative disorder.
Comparison of reconstruction of lateral femoral wall or not to operative effect of femoral intertrochanteric fracture treated with PFNA
Authors: Xia Guofeng , Li Xiaoliang , Tao Chunsheng , Liu Qi , Sun Peifeng 
Published: October 2023

Abstract
Objective To compare the clinical efficacy of PFNA combined with locking reconstruction plate and PFNA for femoral intertrochanteric fractures of lateral wall fractue.
Methods A retrospective study was conducted on 50 patients who received PFNA for femoral intertrochanteric fractures complicated with lateral wall fractures in our department from January 2017 to December 2021. According to the preoperative doctor-patient communication, 26 patients underwent PFNA and lateral wall reconstruction with a locking plate (group A), while the other 24 patients received PFNA alone (group B). The perioperative period, follow-up and imaging data of the two groups were compared.
Results All the patients were operated on smoothly without nerve and vascular injury. Although there were no significant differences in operation time, intraoperative blood loss, total incision length, intraoperative fluoroscopy times, success rate of the first nail placement, screw blade length, incision healing grade and hospital stay between the two groups (P>0.05), the group A resumed ambulation significantly earlier than the group B [((14.01±1.62) days vs (18.83±2.94) days, P< 0.05]. All patients in both groups were followed up for an average of (23.98±4.41) months, and the reconstruction group returned to full weight- bearing activity significantly earlier than the non-reconstructed group [(13.46±3.51) weeks vs (16.5±3.02) weeks, P<0.05]. The Harris score, hip extension-flexion range of motion (ROM) and adduction- abduction ROM significantly increased in both groups with postoperative time (P<0.05), which in the group A proved significantly better than those in group B at all time points accordingly (P<0.05). Radiologically, there was no significant difference in reduction quality between the two groups (P>0.05). At the last follow- up, the group A was also significantly superior to the group B in terms of neck-shaft angle (NSA) [(127.54±2.76)° vs (125.79±1.44)°, P<0.05] and extent of femoral head-neck shortening [(4.06±0.70) mm vs (5.04± 0.62) mm, P<0.05].
Conclusion The lateral wall reconstruction in PFNA fixation of femoral intertrochanteric fractures does enhance the stability of fixation, facilitate the functional recovery of hip joint and reduce complications in this study.
Phytochemical Composition, Antimicrobial, Anticancer Properties and Molecular Docking Profiles of Tragopogon coelesyriacus Boiss. Extracts
Authors: Unver Tuba , Uzuner Ugur , Celik-Uzuner Selcen , Gurhan Ismet , Sivri Nur Sena , Ozdemir Zeynep 
Published: October 2023

Abstract
Tragopogon coelesyriacus is a biennial herbaceous plant of the Asteraceae family that grows mainly in Europe and Asia and is consumed as a vegetable in Turkey. This study aimed to obtain methanol and water extracts from aerial parts (stem, leaf, and flower) of the T. coelesyriacus to determine its phenolic compounds and subsequently to determine the antimicrobial and anticancer activities of T. coelesyriacus extracts as well as in silico molecular docking profiles for targets. T. coelesyriacus methanol extract had a higher inhibitory effect against S. aureus, P. aeruginosa, and K. pneumonia (MIC: 0.83, 1.67 and 1.67 mg/mL, respectively) than E. coli and E. aerogenes (MIC: 53.3 mg/mL). Antifungal activity was observed against all Candida species, with the highest inhibition against C. krusei (MIC: 0.83 mg/mL). In contrast, T. coelesyriacus water extract had no inhibitory effect. Furthermore, both extracts of T. coelesyriacus showed a significant cytotoxic effect on AR42J pancreatic cancer cells. However, HeLa cervical and MDA-MB-231 breast cancer cells were more resistant to the cytotoxic effect of methanol and water extract, respectively. In silico analyses showed the inhibitory effects of Keracyanin chloride within the extracts on S. aureus MurB protein and the remarkable inhibitory potential of the Naringin molecule on FYN kinase protein regarding AR42J pancreatic cells. This study is the first in vitro and in silico analysis to show T. coelesyriacus antimicrobial and anticancer effects along with molecular docking profiles, and it suggests that T. coelesyriacus can be used as a potent pharmacological and therapeutic-protective agent.
Tracing the maternal lineage of Sus scrofa in Northern India and its correlation with ancient human migration patterns
Authors: Sahu Khusbu , Gupta Sandeep Kumar 
Published: October 2023

Abstract
We aimed to explore the distribution and variation of porcine mitochondrial DNA (mtDNA) lineages in northern India. The mtDNA control region (417 bp) was sequenced from 83 domestic pigs from three North Indian states. The 18 haplotypes that were obtained were compared with 1518 published mtDNA control region sequences of Sus scrofa from various regions across the world. The analysis revealed complex clustering patterns of porcine haplotypes with distinct phylogeographic signals. The study unveiled diverse maternal lineages among the domestic pig populations in northern Indian states situated in the foothills of the majestic Himalayas. Additionally, the study identified the presence of two distinct subspecies of wild boar in India (W1 and W2), demonstrating their migration routes and offering a strong phylogeographic signal. Evidence for a separate domestication center in the Himalayan foothills and Indian sub-continent was found within Mixed Clade 5 (MC5). A novel clade (MC4) with a localized distribution in the Chotanagpur plateau was detected, suggesting a unique population of wild boar in this region. Diverse maternal lineages among domestic pigs were observed, which may reflect human-mediated dispersal of pigs within and into the region; hence, a hypothesis linking ancient human migration with the presence of these maternal lineage clades has been proposed. Overall, the porcine haplotypes discovered in the Indian subcontinent highlight its unique and significant contribution to genetic resources.
Optimization of the computational domain for EHL point contacts
Authors: higashitani yuko , Kawabata Sanemasa , Björling Marcus , Almqvist Andreas 
Published: October 2023

Abstract
Many investigations of the oil film thickness and friction in the EHL point contact under starved and flooded conditions are conducted. However, in these investigations the lubrication regions are limited and there is a lack of numerical investigations on the lubrication performance, which considers the transition regions between the lubrication regimes. To ensure accurate calculations that encompass the transition between the lubrication regime in the EHL point contact, we propose a normalization method for the optimized computational domain which is not based on the Hertzian radius. Furthermore, the outlet side is defined to satisfy continuity conditions, including cavitation, at the exit boundary. Hence, employing the proposed normalization method can help to improve the accuracy and reliability of the numerical analysis of machine assemblies including rolling-sliding parts, which operate under EHL conditions. This is foreseen to lead to better design of these assemblies, potentially improving their lifespan and efficiency.
Experimental tests and modeling of H2S-CO2-brine systems – a case study
Authors: Labus Krzysztof 
Published: October 2023

A geochemical study aimed to determine the impact of CO2 and H2S, mixtures on the representative formation rocks from the Dębowiec Fm. and Paralic series of the Upper Silesian Coal Basin, and the adjacent Małopolska Block (Poland) was performed.In the way of experiments and hydrochemical modeling the following goals were achieved: determination of the impact of acid gases on the mineralogical composition and porosity, and the assessment of mineral trapping capacity of cap rocks.Dissolution of skeletal grains, as the dominant process (the most distinct in carbonates and chlorite) was determined by means of SEM analysis in all of the samples.The increase in porosity at the injection stage, depending on the mineralogy of samples was caused by the decomposition of calcite and siderite or ankerite (Dębowiec Fm.), daphnite, clinochlore, and siderite (Paralic series) and hematite, ankerite, dolomite (Małopolska Block).After 10 000 years of simulated storage, the total porosity decreased in the cap rocks by several percent points, mainly due to precipitation of saponite, muscovite, gibbsite, phlogopite and dawsonite, in favor of the rock insulating properties. Among the secondary minerals enabling the trapping of CO2 and S in simulated storage there were observed: dolomite and pyrite (Dębowiec Fm.), dolomite, calcite and pyrite (Paralic series) and siderite, anhydrite, pyrite (Małopolska Block).Maximum calculated mineral-trapping capacity, calculated based on the results of kinetic modeling, reached 43.4 kgCO2/m3 and 44.9 kgS/m3 for CO2+ H2S co-injection into the Dębowiec Fm. Miocene rock.
Synergy scenario for renewable energy production, CO2 and H2 storage in the Baltic offshore structure
Authors: Shogenov Kazbulat , Shogenova Alla 
Published: October 2023

CO2 Capture, Transport, Use and Storage (CCUS) is one of the core technologies to mitigate climate change. New techno-economic and techno-ecological concept of a synergy of CO2 geological storage (CGS), CO2 use, hydrogen (H2) production from different eco-friendly renewable energy recovery technologies and underground H2 storage (UHS), which we call here Geological Power Bank (Geo-PB), in Cambrian Deimena Formation sandstones in different compartments of the E6 structure offshore Latvia is presented for the first time. A five-phase circular economy concept of E6 geological structure energy and CO2 storage hub was developed in this study. The workflow is techno-ecological, eco-friendly, self-supporting, cost-competitive, and economically feasible. It consists of (1) CO2 transport by ships to the rig, (2) CO2 injection for CGS and CO2 Plume Geothermal technology (CPG), (3) H2 production, (4) Geo-PB, and (5) H2 transport by the same ships to the customers. The concept is supporting a win8 situation - innovative elements of techno-ecological synergy in one site: (1) CGS, (2) CPG, (3) solar energy, (4) wind energy, (5) sea currents energy, (6) H2 production (7) Geo-PB and (8) H2 transport to consumers. The proposed cycle is closed, demonstrating the principles of circular economy, which will increase the total efficiency of the concept. CGS and CPG are planned in the E6-A compartment of the E6 geological structure with an average CO2 storage capacity of 365 Mt in an optimistic approach and Geo-PB is planned in E6-B with an H2 storage capacity of 119 kt.The Baltic offshore scenario is ambitious and innovative, proposed new technologies, synergy with renewable energy (geothermal, solar, wind and sea current), large storage capacity, including CO2 storage and use captured by a CCUS clusters of emission sources from energy production, cement industry and bio-emissions from Estonia, Latvia and Lithuania. The concept aimed to decrease the artificial impact of climate change by avoiding CO2 emissions to the atmosphere and implementing circular economy principles. It will increase public and policymakers’ acceptance of new underground CO2 and energy storage technologies. The proposed synergy solution for CGS and energy storage projects will make such a business economically feasible and attractive for investors. Our study demonstrates a new era, the next generation of cost-competitive, self-supporting conceptual techno-ecological examples of a possible synergy of storage concepts with renewable energies combined using circular economy approaches.
A quality-control framework for sub-daily flow and level data for hydrological modelling in Great Britain
Authors: Fileni Felipe , Fowler Hayley J. , Lewis Elizabeth , McLay Fiona , Yang Longzhi 
Published: October 2023

Abstract
The absence of an accessible and quality-assured national flow dataset is a limiting factor in sub-daily hydrological modelling in Great Britain. The recent development of measuring authority APIs and projects such as the Floods and Droughts Research Infrastructure (FDRI) programme aim to facilitate access to such data. Basic quality-control (QC) of 15-minute data is performed by the data collection authorities and the National River Flow Archive (NRFA). Still, there is a need for a comprehensible and verifiable quality control methodology. This paper presents an initial assessment of the available data and examines what needs to be done for applicability of the data at national scale. The 15-minute flow series has many inconsistencies, and there are also inconsistencies with the NRFA Annual Maximum values. When producing a QCed dataset, decisions regarding the retention of data values need to be taken and recorded. Furthermore, QC should remove and rectify erroneous values, such as negative and above world record flows; and an assessment of homogeneity and truncated values in the stations could be beneficial to flag suspect data. The complex chain for production and changeability of flow and level data makes data curation and governance imperative to assure the longevity of the dataset.
Recent Advances in Protein Folding Pathway Prediction through
Computational Methods
Authors: Zhao Kailong , Liang Fang , Xia Yuhao , Hou Minghua , Zhang Guijun 
Published: October 2023

Abstract:
The protein folding mechanisms are crucial to understanding the fundamental
processes of life and solving many biological and medical problems. By studying the
folding process, we can reveal how proteins achieve their biological functions through
specific structures, providing insights into the treatment and prevention of diseases.
With the advancement of AI technology in the field of protein structure prediction, computational
methods have become increasingly important and promising for studying protein
folding mechanisms. In this review, we retrospect the current progress in the field
of protein folding mechanisms by computational methods from four perspectives: simulation
of an inverse folding pathway from native state to unfolded state; prediction of early
folding residues by machine learning; exploration of protein folding pathways
through conformational sampling; prediction of protein folding intermediates based on
templates. Finally, the challenges and future perspectives of the protein folding problem
by computational methods are also discussed.
Purinergic Signaling and its Role in the Stem Cell Differentiation
Authors: Zaib Sumera , Areeba  , Khan Imtiaz 
Published: October 2023

Abstract:
Purinergic signaling is a mechanism in which extracellular purines and pyrimidines interact
with specialized cell surface receptors known as purinergic receptors. These receptors are divided
into two families of P1 and P2 receptors, each responding to different nucleosides and nucleotides.
P1 receptors are activated by adenosine, while P2 receptors are activated by pyrimidine and
purines. P2X receptors are ligand-gated ion channels, including seven subunits (P2X1-7). However,
P2Y receptors are the G-protein coupled receptors comprising eight subtypes
(P2Y1/2/4/6/11/12/13/14). The disorder in purinergic signaling leads to various health-related issues
and diseases. In various aspects, it influences the activity of non-neuronal cells and neurons. The
molecular mechanism of purinergic signaling provides insight into treating various human diseases.
On the contrary, stem cells have been investigated for therapeutic applications. Purinergic signaling
has shown promising effect in stem cell engraftment. The immune system promotes the autocrine
and paracrine mechanisms and releases the significant factors essential for successful stem cell therapy.
Each subtype of purinergic receptor exerts a beneficial effect on the damaged tissue. The most
common effect caused by purinergic signaling is the proliferation and differentiation that treat different
health-related conditions.
Advances in The Treatment of Intrahepatic Cholangiocarcinoma-ICLCA
Authors: Jha Anand Mohan , Vinayak B Angadi Dr , Kuriri Hadi , Manam Mani Srikanth Dr , Asmita Rohan Sakore Dr 
Published: October 2023

Intrahepatic cholangiocarcinoma (iCLCA) is a fatal hepatobiliary tumor becoming more common. For a long time, it was largely ignored as an uncommon cancer and commonly misdiagnosed as carcinoma of unidentified origin; nonetheless, significant clinical and research attention has been dedicated to it lately. First-line (gemcitabine and cisplatin), second-line (FOLFOX), and adjuvant (capecitabine) systemic chemotherapy is the accepted standard of treatment. iCLCA is genetically unique from hepatocellular carcinoma, with multiple targetable genetic abnormalities reported to be far. Indeed, FGFR2, NTRK fusions, IDH1, and BRAF targetable mutations have been thoroughly studied, and clinical evidence on pharmacologically targeting these oncogenic drivers is emerging. In addition, the role of immunotherapy has been investigated and is a hot topic. There is a need for therapeutic interventions for these ailments. Our review focuses on Intrahepatic cholangiocarcinoma, cholangiocarcinoma, Extrahepaticcholangiocarcinoma, Vascular Epidermal Growth Factor, IDH inhibitors, and Liver Cancer.