bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty Acid Methyl Ester Profiling of Californian Xylella fastidiosa Strains
Authors: Wallis Christopher M. , Chen Jianchi 
Published: November 2023

Xylella fastidiosa ssp. fastidiosa ( Xff) is the causal agent of Pierce's disease of grapevine, a management-intensive and potentially deadly disease. However, different stains and other subspecies, such as Xylella fastidiosa ssp. multiplex ( Xfm), exist in the same regions and vary in capacity to cause disease. All strains differ in the fatty acids that comprise cell membranes, as these allow adaptations to specific host microenvironments. Therefore, studies were initiated to observe the fatty acid profiles of different Californian Xf isolates via fatty acid methyl ester (FAME) analysis. Observations revealed that the four Xff strains had similar FAME profiles that were distinct from those of the three Xfm strains, even in isolates that originated from the same host plant species. These data show consistent differences between Xff and Xfm strains and demonstrate the potential that FAME profiling has for Xylella subspecies identification of novel isolates. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.
Impact of Intraoperative Fluctuations of Cardiac Output on Cerebrovascular Autoregulation: An Integrative Secondary Analysis of Individual-level Data
Authors: Kahl Ursula , Krause Linda , Amin Sabrina , Harler Ulrich , Beck Stefanie , Dohrmann Thorsten , Mewes Caspar , Graefen Markus , Haese Alexander , Zöllner Christian , Fischer Marlene 
Published: November 2023

Background:
Intraoperative impairment of cerebral autoregulation (CA) has been associated with perioperative neurocognitive disorders. We investigated whether intraoperative fluctuations in cardiac index are associated with changes in CA.

Methods:
We conducted an integrative explorative secondary analysis of individual-level data from 2 prospective observational studies including patients scheduled for radical prostatectomy. We assessed cardiac index by pulse contour analysis and CA as the cerebral oxygenation index (COx) based on near-infrared spectroscopy. We analyzed (1) the cross-correlation between cardiac index and COx, (2) the correlation between the time-weighted average (TWA) of the cardiac index below 2.5 L min−1 m−2, and the TWA of COx above 0.3, and (3) the difference in areas between the cardiac index curve and the COx curve among various subgroups.

Results:
The final analysis included 155 patients. The median cardiac index was 3.16 [IQR: 2.65, 3.72] L min−1 m−2. Median COx was 0.23 [IQR: 0.12, 0.34]. (1) The median cross-correlation between cardiac index and COx was 0.230 [IQR: 0.186, 0.287]. (2) The correlation (Spearman ρ) between TWA of cardiac index below 2.5 L min−1 m−2 and TWA of COx above 0.3 was 0.095 (P=0.239). (3) Areas between the cardiac index curve and the COx curve did not differ significantly among subgroups (<65 vs. ≥65 y, P=0.903; 0 vs. ≥1 cardiovascular risk factors, P=0.518; arterial hypertension vs. none, P=0.822; open vs. robot-assisted radical prostatectomy, P=0.699).

Conclusions:
We found no meaningful association between intraoperative fluctuations in cardiac index and CA. However, it is possible that a potential association was masked by the influence of anesthesia on CA.
Distribution of Pathogenic Bacteria and Antimicrobial Resistance after Plastic Surgery for Microtia
Authors: Hu Jintian , Chen Qi , Jiang Fengli , Wu Yuanyuan , Su Xueshang , Zhuang Jun , Zhan Sien 
Published: November 2023

Background:
Microtia, or congenital malformation (smallness or absence) of the outer ear, can be treated with ear prosthetics and/or surgery.

Methods:
Between January 2011 and December 2021, following plastic surgery, microbial strains from patients with microtia were collected, identified, and counted. WHONET 5.6 was used to analyze in vitro drug resistance of the microbial strains, according to procedures outlined by the Clinical and Laboratory Standards Institute (document M100, 2021). Data regarding surgical techniques, the duration of infection, and other clinical details were also collected.

Results:
A total of 261 patients were included in the study. Among these, 235 Gram-positive bacteria were detected, with Staphylococcus aureus (140/235) and coagulase-negative staphylococci (84/235) accounting for the majority. There were also 26 Gram-negative bacteria, of which Enterobacter (11/26) and Pseudomonas aeruginosa (7/26) were the most common. According to the results of testing for antimicrobial resistance, S. aureus was highly sensitive to cotrimoxazole, levofloxacin, vancomycin, chloramphenicol, and linezolid, whereas coagulase-negative staphylococci were highly sensitive to vancomycin and linezolid. Both were highly resistant to penicillin and erythromycin. In this study, the pathogenic bacteria involved in postoperative infections varied overall, but the most prevalent was S. aureus. The infections appeared mainly in the late postoperative period. A total of 24,548 procedures were performed in the same period, and the infection rate was 1.06%.

Conclusions:
Gram-positive bacteria are the major cause of infection following plastic surgery for microtia. The bacterial species, degrees of antimicrobial resistance, and length of infection varied among the various surgical procedures.
Donor Risk Factors and Environmental Conditions Associated With Poor-Quality Corneas: An Analysis of the Central Eye Bank of Iran (2018–2021)
Authors: Javadi Fatemeh , Khorrami Zahra , Ashrafi Sadra , Abolhosseini Mohammad , Kanavi Mozhgan Rezaei , Safi Sare 
Published: November 2023

Purpose:
The purpose of this study was to investigate the donor risk factors and environmental conditions associated with poor-quality corneas using the database of the Central Eye Bank of Iran over 4 years.

Methods:
This cohort study was conducted on the recorded data of all donated corneas at the Central Eye Bank of Iran database from March 2018 to March 2022. Donors' characteristics and tissue variables were extracted from the database. The final corneal quality was determined based on slitlamp biomicroscopic observations and the results of specular microscopy. Environmental variables were also obtained from reliable resources. Risk factors for poor-quality corneas were calculated using logistic mixed-effect regression analysis. All analyses were performed with STATA 17.0. The significance level of 0.05 was considered for all the analyses.

Results:
The data of 20,625 eyes of 10,601 donors were evaluated. We found that donor age had an inverse correlation with endothelial cell density (r = −0.28, P < 0.001). The trend of donated corneal poor quality decreased between 2018 and 2021. Several factors, including intoxication (odds ratio [OR] = 1.29), obesity (OR = 1.34), diabetes mellitus (OR = 1.63), hypertension (OR = 1.52), and pseudophakic eyes (OR = 1.56), were associated with the poor quality of donated corneal tissues. The outdoor temperature over 26°C was associated with higher odds of poor corneal quality (OR = 1.31), whereas high relative humidity decreased the odds of poor corneal quality (OR = 0.82).

Conclusions:
This study revealed that the cause of donor death, obesity, donor comorbidities, pseudophakia, and environmental factors could affect the corneal quality and make the donated corneas less suitable for transplantation.
Quality and Agreement With Scientific Consensus of ChatGPT Information Regarding Corneal Transplantation and Fuchs Dystrophy
Authors: Barclay Kayson S. , You Jane Y. , Coleman Michael J. , Mathews Priya M. , Ray Vincent L. , Riaz Kamran M. , De Rojas Joaquin O. , Wang Aaron S. , Watson Shelly H. , Koo Ellen H. , Eghrari Allen O. 
Published: November 2023

Purpose:
ChatGPT is a commonly used source of information by patients and clinicians. However, it can be prone to error and requires validation. We sought to assess the quality and accuracy of information regarding corneal transplantation and Fuchs dystrophy from 2 iterations of ChatGPT, and whether its answers improve over time.

Methods:
A total of 10 corneal specialists collaborated to assess responses of the algorithm to 10 commonly asked questions related to endothelial keratoplasty and Fuchs dystrophy. These questions were asked from both ChatGPT-3.5 and its newer generation, GPT-4. Assessments tested quality, safety, accuracy, and bias of information. Chi-squared, Fisher exact tests, and regression analyses were conducted.

Results:
We analyzed 180 valid responses. On a 1 (A+) to 5 (F) scale, the average score given by all specialists across questions was 2.5 for ChatGPT-3.5 and 1.4 for GPT-4, a significant improvement (P < 0.0001). Most responses by both ChatGPT-3.5 (61%) and GPT-4 (89%) used correct facts, a proportion that significantly improved across iterations (P < 0.00001). Approximately a third (35%) of responses from ChatGPT-3.5 were considered against the scientific consensus, a notable rate of error that decreased to only 5% of answers from GPT-4 (P < 0.00001).

Conclusions:
The quality of responses in ChatGPT significantly improved between versions 3.5 and 4, and the odds of providing information against the scientific consensus decreased. However, the technology is still capable of producing inaccurate statements. Corneal specialists are uniquely positioned to assist users to discern the veracity and application of such information.
The Managerial Role and Psychosocial Factors of Job Satisfaction
Authors: Colin-Chevalier Rémi , Pereira Bruno , Dewavrin Samuel , Cornet Thomas , Zak Marek , Benson Amanda Clare , Dutheil Frédéric 
Published: November 2023

Objective
Job satisfaction is an emerging indicator for measuring workers’ occupational well-being; however, this has been poorly studied in managers. We aimed to explore job satisfaction between managers and employees and assess its factors.

Methods
Data from Wittyfit’s users were collected between January 2018 and February 2020. Volunteers anonymously provided their sociodemographic profile, their sense of job satisfaction, and their psychosocial feelings (ambiance, meaning, organization, recognition, values, work-life balance).

Results
Data of 10,484 employees and 836 managers were collected. Job satisfaction was higher in managers than employees. All psychosocial factors had an impact on job satisfaction in workers. There was a higher prevalence of satisfied managers than employees. Managerial position and other sociodemographic variables influenced this prevalence.

Conclusions
Managers seem to be more satisfied than employees. Psychosocial and sociodemographic factors can influence workers’ job satisfaction.
Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits
Authors: Nematollahi Amy J. , Fisher Julia M. , Furlong Melissa A. , Beamer Paloma I. , Goodrich Jaclyn M. , Graber Judith M. , Calafat Antonia M. , Botelho Julianne Cook , Beitel Shawn C. , Littau Sally R. , Gulotta John J. , Wallentine Darin D. , Burgess Jefferey L. 
Published: November 2023

Objective
Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits.

Methods
Serum PFAS concentrations were measured in 99 incumbent and 55 recruit firefighters at enrollment in 2015–2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models.

Results
Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations.

Conclusions
Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.
Case report and literature review: Fabry disease misdiagnosing as polymyalgia rheumatica
Authors: Yanfang Wu , Juanjuan He , Shengli Zhang , Lei Yin , Fei Gao 
Published: November 2023

Rationale:
The clinical manifestations of Fabry disease affect the nerves, kidneys, heart, skin, gastrointestinal tract and eyes. Our aim is to familiarize people with the FD diagnostic process by reporting this case.

Patient concerns:
A 79-year-old-male patient presented with muscle pain and weakness in the extremities, also with an increasing erythrocyte sedimentation rate and C-reactive protein. Further examinations revealed that multiple organ involvement, such as rash, myocardial hypertrophy, peripheral neuropathy.

Diagnoses:
Cardiac MR demonstrated hypertrophic cardiomyopathy, myocardial fibrosis and low myocardial T1 value. The patient was eventually diagnosed with Fabry disease through proteomics and genetic testing.

Interventions:
The treatment is enzyme replacement therapy (ERT). But this patient could not afford ERT and was given only general symptomatic treatment, pregabalin, and a gradual reduction in glucocorticoid.

Outcomes:
The patient’s symptoms of joint pain and muscle weakness reduced significantly, and ESR and CRP had decreased to normal.

Lessons:
FD is a rare disease and difficult to diagnose, but rare does not mean invisible. FD may present with signs and symptoms of rheumatic diseases. Rheumatologists should be aware and concerned about this disease.
A modern approach with follower-leading clustering algorithm for visualizing author collaborations and article themes in skin cancer research: A bibliometric analysis
Authors: Lai Po-Chih , Chou Willy , Chien Tsair-Wei , Lai Feng-Jie 
Published: November 2023

Background:
Skin cancers (SCs) arise due to the proliferation of atypical cells that have the potential to infiltrate or metastasize to different areas of the body. There is a lack of understanding regarding the country-based collaborations among authors (CBCA) and article themes on SCs. A clustering algorithm capable of categorizing CBCA and article themes on skin cancer is required. This study aimed to apply a follower-leading clustering algorithm to classify CBCA and article themes and present articles that deserve reading in recent ten years.

Methods:
Between 2013 and 2022, a total of 6526 articles focusing on SC were extracted from the Web of Science core collection. The descriptive, diagnostic, predictive, and prescriptive analytics model was employed to visualize the study results. Various visualizations, including 4-quadrant radar plots, line charts, scatter plots, network charts, chord diagrams, and impact beam plots, were utilized. The category, journal, authorship, and L-index score were employed to assess individual research achievements. Diagnostic analytics were used to cluster the CBCA and identify common article themes. Keyword weights were utilized to predict article citations, and noteworthy articles were highlighted in prescriptive analytics based on the 100 most highly cited articles on SC (T100SC).

Results:
The primary entities contributing to SC research include the United States, the University of California, San Francisco in US, dermatology department, and the author Andreas Stang from Germany, who possess higher category, journal, authorship, and L-index scores. The Journal of the American Academy of Dermatology has published the highest number of articles (n = 336, accounting for 5.16% of the total). From the T100SC, 7 distinct themes were identified, with melanoma being the predominant theme (92% representation). A strong correlation was observed between the number of article citations and the keyword weights (F = 81.63; P < .0001). Two articles with the highest citation counts were recommended for reading.

Conclusion:
By applying the descriptive, diagnostic, predictive, and prescriptive analytics model, 2 noteworthy articles were identified and highlighted on an impact beam plot. These articles are considered deserving of attention and could potentially inspire further research in the field of bibliometrics, focusing on relevant topics related to melanoma.
The impact of two dietary patterns on hyperuricemia in adults: A meta analysis of observational studies
Authors: Liu Can , Kuang Xin , Gu Mingxiao , Liu Xuancheng , Lu Jiao , Yu Haiqing 
Published: November 2023

Background:
Hyperuricemia (HUA) is a crucial factor contributing to some chronic diseases among adults. In past observational literatures, scholars have debated the effectiveness of dietary pattern on HUA and inconsistencies exist. Given this condition, the study aimed to provide a comparative assessment of the relation between dietary pattern and HUA risk and offer implications to policy makers.

Methods:
A systematic research was undertaken in PubMed, Web of Science, Cochrane, Embase, Medicine, ScienceDirect and Medline to identify observational studies examining the effect of dietary pattern on HUA, and search period was from past to January 2022. Meta analysis was applied by using the Stata version 11.0 software.

Results:
A total of 34,583 adults from 8 observational studies, 45,525 adults from 6 observational studies were included to examine the effectiveness of “healthy” and “meat/western” dietary patterns on HUA risk respectively. The findings suggested that “healthy” dietary pattern significantly decreased the HUA risk (OR = 0.73; 95% CI: 0.61–0.88) both in Eastern countries (OR = 0.79; 95% CI: 0.64–0.98) and Western countries (OR = 0.53; 95% CI: 0.30–0.92) while the “Meat/Western” pattern increased the HUA possibilities (OR = 1.26; 95% CI: 1.17–1.37). Stratified analysis exhibited that “healthy” pattern reduced HUA risk in adults was more effective in cohort study (OR = 0.79; 95% CI: 0.72–0.86).

Conclusions:
This study’s findings highlighted the potential benefit of healthy dietary pattern in decreasing HUA risk. Accordingly, implementing policy makers of countries should enhance to appeal adults to keep a healthy diet, offer financial support to low-income staff, or provide guidelines for adult’s dietary behavior changes.

Trial registration number:
INPLASY: INPLASY202290034.
The association between circulating Hcy and Lp-PLA2 levels and poststroke depression: A meta-analysis
Authors: Tao Yongjun , Wang Wenmin , Zhao Jiang , Xu Xiaohui , Ke Jinfeng , Ke Xiaoyong 
Published: November 2023

Objective:
To analyze the correlation between circulating homocysteine (Hcy) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and poststroke depression (PSD).

Materials and methods:
Chinese (Chinese National Knowledge Infrastructure, Wanfang, and VIP) and English (PubMed, EMBASE, MEDLINE, and Cochrane Library) databases on the correlation between circulating Hcy and Lp-PLA2 and PSD were collected. Meta-analysis was performed to compare the distinctions in circulating Hcy and Lp-PLA2 levels between PSD and non-PSD groups. Meta-analysis was conducted by using STATA 15.0 software.

Results:
A total of 20 literatures were included in this study. The level of circulating Lp-PLA2 in the PSD group was obviously higher than that in the non-PSD group (weighted mean differences: 2.75, 95%CI: 0.10–5.39, P = .002), which was an independent predictor of PSD (effect size = 0.05, 95%CI: 0.03, 0.07, P < .001). The level of circulating Hcy in the PSD group was obviously higher than that in the non-PSD group (weighted mean differences = 1.41, 95%CI: 1.01, 1.81, P < .001), which was an independent influencing factor for the occurrence of PSD (effect size = 0.07, 95%CI: 0.04, 0.09, P = .011).

Conclusion:
Circulating Hcy and Lp-PLA2 levels are linked to the development of PSD, and can be applied as predictive or diagnostic indicators.
Establishment and validation of a clinical diagnostic model for gastric low-grade intraepithelial neoplasia
Authors: Sun Ting , Ke Xi-quan , Wang Meng , Wang Qi-zhi 
Published: November 2023

Objective:
A clinical diagnostic model of gastric low-grade intraepithelial neoplasia (LGIN) was developed and validated to improve the identification of precancerous lesions in gastric cancer.

Methods:
A retrospective analysis of 1211 patients with chronic atrophic gastritis (CAG) and 1089 patients with LGIN admitted to the Endoscopy Center of the First Affiliated Hospital of Bengbu Medical College from January 2016 to December 2021 was performed to record basic clinical and pathological information.
A total of 1756 patients were included after screening and were divided unequally and randomly into 2 groups, one for establishing an LGIN predictive nomogram (70% of patients) and the other for external validation of the model (30% of patients). R software was used for statistical analysis.

Results:
The nomogram was built with 10 predictors: age, sex, lesion location, intestinal metaplasia, multiple location, lesion size, erosion, edema, surface white fur, and form. The calibration curves showed good agreement between the predicted and actual diagnoses. The C-indexes were 0.841 (95% CI: 0.820–0.863) in the training dataset, 0.833 in the internal validation dataset, and 0.842 in the external validation dataset (Hosmer–Lemeshow test, P = .612), showing satisfactory stableness.

Conclusions:
This study provides a visual mathematical model that can be used to diagnose high-risk LGIN, improve follow-up or endoscopic treatment and the detection rate of precancerous gastric cancer lesions, reduce the incidence of gastric cancer, and provide a reliable basis for the treatment of LGIN.
Establishment and assessment of a nomogram for predicting prognosis in bone-metastatic prostate cancer
Authors: Liu Wenfei , Wang Zhiyong , Wu Yanying , Li Lingchao 
Published: November 2023

Objective:
For the purposes of patients’ consultation, condition assessments, and guidance for clinicians’ choices, we developed a prognostic predictive model to evaluate the 1-, 3-, and 5-year overall survival (OS) rates of bone-metastatic prostate cancer (PCa) patients.

Methods:
We gathered data from 5522 patients with bone metastatic PCa registered in the Surveillance, Epidemiology, and End Results (SEER) database to develop a nomogram. A total of 359 bone metastatic PCas were collected from 2 hospitals to validate the nomogram and assess its discriminatory ability. In addition, we plotted the actual survival against the predicted risk to assess the calibration accuracy. Moreover, we designed a web calculator to quickly obtain accurate survival probability outcomes.

Results:
Univariate and multivariate Cox hazard regression analyses suggested that age, marital status, prostate-specific antigen (PSA) level, Gleason score, clinical T stage, N stage, surgery, and chemotherapy were closely associated with OS rates. The calibration charts of the training and validation groups showed a high accuracy and reliability. The decision curve analysis (DCA) suggested a favorable clinical net benefit.

Conclusion:
Based on demography and clinical pathology, we developed a reliable nomogram to help clinicians more accurately predict the 1-, 3-, and 5-year OS rates of patients with bone metastatic PCa to guide evaluation and treatment.