bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les « communs négatifs » et se démettre en commun
Authors: Stavo-Debauge Joan 
Published: December 2023

Cet article s’emploie à problématiser la manière dont les « communs négatifs » interrogent l’hospitalité, en nous posant les questions suivantes : sommes-nous prêts à accueillir la fin de mondes auxquels nous ne parvenons pas à désappartenir ? Comment penser une communauté qui se constitue en se démettant d’attaches écologiquement néfastes ?
Mutualismes diffus
Authors: Sharma Kriti , Bigé Emma 
Published: December 2023

Les reconfigurations du biologique et du naturel peuvent ouvrir bien des possibilités politiques et ontologiques qui s’opposent aux lieux communs qui y voient des contraintes limitant les possibilités politiques. Cet article commence au fond des océans, où les recherches sur la vie microbienne dans les sédiments marins suggèrent un excès qui ne peut être contenu dans les récits biologiques de la compétition individualiste pour la survie. Nous remontons à la surface pour converser avec Sylvia Wynter, dont la critique acérée du naturalisme qui fonde et perpétue le capitalisme racial détermine un argument fondateur pour la nécessité éthique et politique de reconfigurer l’humain, le naturel et le biologique. La théorie écologique des « mutualismes diffus » répond à l’appel de Wynter à développer des « sciences hérétiques » capables de déplacer la vision de l’Homme comme être bioéconomique.
« Nous sommes la contre-nature qui se défend »
Authors: Bigé Emma 
Published: December 2023

Les écologies queers sont pleines de créatures indociles, non seulement aux schémas binaires mâle/femelle, hétéro/homo, cis/trans, mais encore aux mondes compétitifs individualistes sur lesquels ces schémas sont fondés. Elles sont ainsi « la contre-nature qui se défend » d’être contre-nature , c’est-à-dire qu’elles montrent que les formes réputées déviantes du genre, de la sexualité, de la parenté et de famille, sont bien plus répandues que les sciences hétéropatriarcales n’ont bien voulu l’admettre. Mais elles sont aussi « la contre-nature qui se défend » contre les assauts du capitalisme extractiviste , en montrant le caractère idéologique des idées de prédation, de lutte pour la survie et pour la transmission du patrimoine génétique individuel. À la place, suivant les leçons de la bactériologie de Lynn Margulis et des théoriciennes queer qui s’en sont inspirées, il s’agit de penser des formes de parentés et de solidarités pour vivre et mourir sur une planète symbiotique.
Humaines fractures, cercles soignants, cercles de formation
Authors: Gennart Michèle , Vannotti Marco 
Published: December 2023

Notre dispositif de formation à la psychothérapie est intérieurement travaillé par notre façon de penser « l’objet » du soin : l’humain qu’à la fois nous sommes et avons à traiter. La première partie de cette étude qui fait l’objet du présent article vise à commenter ce nœud qui fait la singularité de la psychothérapie. Qu’est-ce qui, dans l’existence humaine, nous expose à la (psycho)pathologie ? Qu’est-ce qui, dans la rencontre interhumaine, peut s’avérer soignant ? En référence à la pensée phénoménologique, les auteurs examinent le statut singulier du phénomène pathique autour duquel s’articulent psychopathologie et psychothérapie. Le « pathique » renvoie à la vulnérabilité multiforme qui marque notre condition humaine. Il signe aussi notre ouverture, notre sensibilité fondamentale à ce qui se produit dans la rencontre ; comme tel, il est constitutif de la fonction thérapeutique. Dans une seconde partie, nous aborderons la question de savoir comment développer une formation à la psychothérapie qui tienne rigoureusement compte de cette implication du soignant.
Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Clinicopathological Features and Short-Term Outcome in Well-Differentiated Thyroid Cancer
Authors: Malapure Sumeet Suresh , Oommen Sibi , Bhushan Shivanand , Suresh Sucharitha , Devaraja K. 
Published: December 2023

Purpose of the Study:
To assess the association of inflammatory markers with known risk factors and short-term outcome of well-differentiated thyroid cancer.

Materials and Methods:
Well-differentiated nonmetastatic thyroid cancer patients diagnosed and treated between September 2015 and December 2019 at Kasturba Hospital, Manipal, India, were retrieved for the study. Patients’ presurgical blood parameters were noted, and neurtrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were calculated. Clinicopathological details along with tumor markers at baseline and at 6 months’ follow-up were tabulated. Patients were categorized as complete disease clearance if their clinical examination was normal, stimulated thyroglobulin (Tg) was <1 ng/ml, Anti-thyroglobulin antibodies <65 IU/L or showing a decreasing trend, and follow-up I-131 whole-body scan was negative. The association of the inflammatory markers with known risk factors and short-term outcomes were compared.

Results:
A total of 272 patients were analyzed in the study. The median NLR in our study cohort was 2.55 (mean = 3.96 with standard deviation [SD] =4.20) and the median LMR was 3.72 (mean = 3.79 with SD = 1.94). The disease clearance rate of our study cohort was 73.9%. The median NLR (2.4 vs. 3.1) and LMR (3.13 vs. 3.93) were significantly different among the patients with complete disease clearance and those with persistent disease (P = 0.008 and P = 0.003, respectively). The known risk factors such as multifocality (P = 0.04), tumor size (P = 0.013), lymph node metastases (P = 0.001), and baseline Tg (P ≤ 0.001) were significantly associated with persistent disease at 6 months. The NLR showed a positive correlation and LMR had a negative correlation with the known risk factors, however, the associations were not statistically significant.

Conclusions:
The NLR and LMR are simple yet potential prognostic tools in well-differentiated thyroid cancer.
Current concepts of mesenchymal stem cell-derived exosome therapy in degenerative rotator cuff tear arthropathy
Authors: Vankdoth Krishna Kanth 
Published: December 2023

Abstract
Ruptures of the rotator cuff are a prevalent issue that are responsible for a sizeable portion of the morbidity that affects the adult population. We can bring the high recurrence rate down by increasing our understanding of the method by which entheses recover. There have been several studies done on mesenchymal stem cells (MSCs) and their influence on the healing of wounds; nevertheless, there are several challenges associated with their application. Recent research has suggested that exosomes may be responsible for the beneficial effects of MSCs on wound healing. Researchers have discovered that exosomes can boost collagen synthesis and angiogenesis. This is accomplished by increasing the expression of mRNA for collagen 1 and elastin, as well as proteins that promote angiogenesis. As a result, scar formation is reduced and tissue regeneration is enhanced. Although there has only been a modest amount of study done on exosome functions and the potential roles they can play in wound healing, it is possible that exosomes are responsible for the underlying mechanisms that give MSCs their healing abilities. Because of this, it is necessary to conduct additional research on their capacity to speed up the healing process of the enthesis in rotator cuff models. When it comes to rotator cuff repair, more research is required to determine which distribution technique of exosomes is the most effective. These issues will be answered as further research and understanding of the role of exosomes is conducted, which will also lead to improvements in the efficiency of tissue regeneration and regenerative medicine.
Management of late presented thoracolumbar spine fracture: Comparison of clinical and radiological outcome in anterior and posterior approach
Authors: Das Subhendu , Chakraborty Abhishek , Mahato Prasanta , Santra Sabyasachi 
Published: December 2023

Abstract

Background:
Between 5% and 10% of polytrauma patients suffer spinal fractures or dislocations. The vast majority of these injuries affect the motion segments between T11 and L2 at the thoracolumbar junction. A few thoracolumbar fractures may be treated conservatively by rigid orthosis and prompt mobilisation, but a large number of such injuries are better managed surgically. A variety of surgical approaches viz. Anterior, posterior or circumferential/combined are used to decompress and stabilise injured thoracolumbar spine. The ideal method is still a matter of some debate, and in most cases, the operative plan is influenced by both clinical and radiological conditions. The purpose of this study was to compare the results of anterior versus posterior decompression and reconstruction of the spine in late presentation (>3 weeks).

Materials and Methods:
A prospective and randomised study was conducted from September 2012 to August 2014. Thirty patients with thoracolumbar spinal fractures (D11–L2) were taken for the study as per inclusion/exclusion criteria. The patients were operated 3 weeks after the injury due to late presentation. All patients underwent decompression and fixation of the spine using various methods either by anterior approach or posterior approach (15 patients in each group). All patients had Thoracolumbar Injury Classification and Severity Score 5 or more with age belonging to the age group of 15–65 years. On admission, American Spinal Injury Association Impairment Score (ASIA score) was evaluated and Frankel grade was assigned to each patient. Operative time, intraoperative blood loss, intraoperative and postoperative complications were noted. Neurology was assessed again at the time of discharge after surgery and at follow-up at month and then at 3-month intervals. Radiological evaluation is done based on a kyphotic angle before surgery and at follow-up visits. Clinical outcome variables analysis was done using an Unpaired t test and Graph Pad software. Significance was set at the P < 0.05 level.

Results:
Of 30 patients, 15 belonged to each group. Group A (operated with an anterior approach) and group B (operated with a posterior approach) were comparable in terms of patient demographics, type of fracture, and follow-up duration. No patient suffered from neurological deterioration post-surgery. ASIA score improvement in group A is 66 points and in group B is 59 points. Frankel grade improvement is up to 1.3 in group A and 1.2 in group B. Cosmetic results were better in a posterior group with the shorter incision.

Conclusion:
With this comparative study, we find that the anterior approach is better in overall outcome if operated after 3 weeks of injury.
Midfoot Charcot neuroarthropathy: An overview
Authors: Simon Rajesh , Zachariah Sunnish 
Published: December 2023

Abstract
Charcot’s neuroarthropathy is a progressive disorder of the foot and ankle involving soft tissue, bones and joints. If not identified and treated in early stages, it can lead to multiple ulcerations, loss of shape of foot with inability to walk or may even lead to amputation. If diagnosed in the early stages, non-operative treatment is very useful in the early stages of disease. Surgical treatment aims at the correction of deformities and halting disease progression, eventually giving a plantigrade osseous stable foot.
Significance of epsilon sign in preoperative planning and surgical reduction of unstable variant of intertrochanteric fracture femur
Authors: Mohan Gopi 
Published: December 2023

Abstract

Introduction:
Intertrochanteric (IT) fractures of the hip are a common variety of fractures seen elderly people. Early mobilisation and ambulation can prevent significant functional disability in these patients. A particularly unstable variant of IT fracture, which appears on radiological examination as an epsilon ‘ε’ sign on the left side and reverse epsilon ‘3’ on the right side, further worsen outcomes. In this study, 354 IT fractures treated at our institution from September 2020 to July 2021, including 15 patients with the unstable fracture type, were retrospectively examined.

Materials and Method:
The Whitman’s technique for fracture reduction by traction, disimpaction and internal rotation of the affected limb was attempted in all patients,. In 13 of these cases, attempts at closed reduction were not successful by any manoeuvre of rotation, whereas in 2 cases a suboptimal closed reduction was achieved following which intramedullary fixation was performed. In all cases where open reduction was required, a lateral approach was performed to expose the fracture site, which was then examined and revealed the soft tissue interposition. Such structures that prevented reduction were then retracted anteriorly and kept away from the fracture site. The fracture was reduced by external rotation of the distal fragment following which the DHS screw was inserted, manual compression was performed to correct any distraction followed by stabilisation using de-rotation screw and application of top nut.

Results:
Of the 354 patients who presented with IT fractures, 15 were identified with the unstable variant. Closed fracture reduction was partially achieved in only 2 of these 15 patients. In the remaining patients, open reduction was required following the failure of closed reduction. The patients with unstable IT fractures who underwent surgical correction following retraction of soft tissue structures and reduction by external rotation of distal fragment showed radiological signs of union post-operatively. In the two patients who achieved suboptimal partial reduction by closed technique, failure of fixation was observed in follow up.

Conclusion:
In our study, we found that the early radiological determination of epsilon ‘ε’ sign on the left side and reverse epsilon ‘3’ on right side could decrease unnecessary attempts at closed reduction and subsequent failure of the same. Prompt open reduction of such fractures can prevent unnecessary attempts at closed reduction, which may fail completely or yield suboptimal results as in our study. The surgical techniques for optimum open reduction in these cases were also elucidated in our study.
Immunohistochemical expression of SOX2 in OKC and ameloblastoma: A comparative study
Authors: Pereira Treville , Shetty Subraj J. , Punjabi Vishal , Vidhale Rutuja G. , Gotmare Swati S. , Kamath Pooja 
Published: December 2023

Introduction:
Odontogenic, non-inflammatory maxillofacial cysts and tumours vary greatly in their ability to grow and cause local tissue destruction. Despite their common embryologic origin, the biologic mechanisms responsible for this diverse array of clinical behaviour are largely unknown. Unfortunately, even with accurate tissue diagnosis and appropriate surgical management, these tumours have relatively high recurrence rates. While this may be related to surgical technique, it may also be due to intrinsic tumour biology. SOX2 is differentially expressed in odontogenic cysts and tumours, which has an impact over patient prognosis. This could be related to their diverse cells of origin or stages of histogenesis. SOX2 is expressed in OKC and ameloblastoma, and in this study, we look forward to find altered levels and intensity of SOX2 in the above-mentioned lesions.

Aim and Objectives:

To profile the expression of SOX2 in odontogenic keratocyst (OKC) and ameloblastomaTo compare the intensity of these lesions, analyse their intrinsic feature and predict their recurrence

Material and Methods:
Histopathologically diagnosed cases of OKC and ameloblastoma will be selected (n = 40). Paraffin-embedded, formalin-fixed sections of these lesions will be stained for SOX2 marker using a standard immunohistochemical technique. Positive control will be taken as oral squamous cell carcinoma and negative control will be taken as normal oral mucosa.

Results:
A comparison between the stained cell types in odontogenic keratocyst and ameloblastoma revealed statistically significant differences. The immunoreactivity scores of SOX2 were analysed in both groups. The results indicated that 45% of OKC cases exhibited strongly positive reactivity, while 65% of ameloblastoma cases were negative. Statistical analysis demonstrated highly significant differences in the frequency of SOX2 expression between the two groups, with a higher frequency of negative expression in ameloblastoma.

Conclusion:
Stem cell markers have been observed in these lesions, suggesting the acquisition of stem-like properties by tumour cells, which can affect patient prognosis. Specifically, the marker SOX2 shows differential expression in odontogenic cysts and tumours. High expression of SOX2 in OKC indicates the presence of stem cells with significant self-renewal and proliferative properties, potentially signifying neoplastic behaviour. In contrast, weak or absent expression of SOX2 in ameloblastoma suggests different molecular pathways involved in its neoplastic behaviour.
Establishing the reliability of incisive papilla and palatal rugae patterns in individual identification
Authors: Satelur Krishnanand P. , Annegowda Vidya M. , Murali Arpitha , Sirisha R. 
Published: December 2023

Context:
The study of palatal rugae forms an important basis of human identification, especially due to mass disasters where routinely used techniques may not be helpful.

Aims:
This study aimed at evaluating the palatal rugae and incisive papilla on the basis of shape.

Settings and Design:
The study was conducted in 280 individuals (males and females) among dental students of Dayananda Sagar College of Dental Sciences.

Materials and Methods:
The study included 280 students from Dayananda Sagar College and out-patients from the orthodontics department. Pictures of rugae and the incisive papilla were taken from individuals aged 10–36 using a camera, mirror, and lighting. Two investigators analysed the shape of the rugae and incisive papilla using classification systems by Thomas and Kotze, and Ortman and Tsao, respectively.

Statistical Analysis Used:
The data were statistically analysed using SPSS 20.0 software, and a significance level of P ≤ 0.05 was used.

Results:
The results suggested that rugae showing a wavy shape were the most common pattern in both the genders. Significant differences were observed in the curved rugae type between males and females. In incisive papillae evaluation, the pear shape was the most common, with the triangular shape being the least common.

Conclusions:
It can be concluded that evaluation of palatal rugae along with the incisive papilla can be an important tool for identification of an individual and for evaluating various ethnic populations.
Assessment of the mineralisation stages of third molars and validation of Mincer et al.’s age estimation method: A retrospective, cross-sectional study in Western India population
Authors: Pillai Jayasankar P. , Dodia Vaishali , Monpara Pooja , Shah Khushali , Odedra Sima 
Published: December 2023

Context:
Age estimation is one of the prime requisites in forensic human identification cases and the criminal justice system. There are several age estimation methods using dental parameters. A method proposed by Mincer et al. which uses the mineralization stages of third molars based on Demirjian’s developmental stages is less tested in the Indian population.

Aim:
The present study aimed to assess the developmental status of the third molars and to apply and validate Mincer et al.’s method on the Western India population.

Methods and Material:
A total of 306 orthopantomograms (OPGs) from 128 males and 178 females with a mean age of 16.89 years ± 3.68 were analysed. Demirjian’s A-H staging was applied to record the developmental stages of 1100 third molars. Mincer et al.’s mean age of attainment was applied based on the American Whites (Caucasian) population for males and females separately using stages of #18 and #38.

Results:
There was a slight overestimation of the chronological age (CA) in both #18 and #38. The females showed more accurate estimated age (EA) than males.

Conclusions:
Mincer et al.’s method is a convenient age estimation method using the third molar’s developmental stage. The mean age of attainment mentioned in the original Mincer et al.’s study can be used in the Western Indian population, with a residual value ranging from 0.21 to 0.25 years.
Overexpression of deubiquitinase (usp 36) in oral squamous cell carcinoma
Authors: Murali Preethi , Kavitha B. , Narasimhan Malathi 
Published: December 2023

Aim:Oral cancer is one of the top three types of cancer and is of significant public health importance in India. A common post-translational modification in cells is ubiquitination/deubiquitination, and its dysregulation is closely associated with the development of cancer. Studies on the role of ubiquitination in oral squamous cell carcinoma (OSCC) are lacking. Increased expression ofusp36has been observed in various types of cancer, and this study aimed to check the gene expression ofusp36in OSCC patients. In this study, we analyzed the expression of ubiquitin-specific proteases (USPs) 36 in OSCC.Materials and Methods:A total of 15 OSCC patients at different stages of tumor differentiation and age- and sex-matched controls were recruited for the study. The patients were categorized based on their differentiation patterns. RNA was extracted from the tissues, andusp36gene expression was checked in these samples using a quantitative real-time PCR technique.Results:Our study showed increased expression ofusp36gene in OSCC patients. Theusp36mRNA was 231.8 ± 137.94 folds higher in well-differentiated squamous cell carcinoma patients, 38.18 ± 3.77 folds higher in moderately differentiated squamous cell carcinoma patients, and 25.49 ± 7.30 folds higher in poorly differentiated squamous cell carcinoma patients compared to control tissues.Conclusion:Our study reports, for the first time, an increased gene expression ofusp36in OSCC tissues.
Comparative evaluation of oral mucositis in oral cancer patients undergoing 3-dimensional conformal radiation therapy and intensity modulated radiation therapy with or without chemotherapy
Authors: Harnekar Shirin H. , Prakash Nilima , Nagarkar Raj , Pradeep GL , Mahajan Aarti , Patil Roshan Kumar A. 
Published: December 2023

Context:
Oral cancer is a significant cause of death across the world. A combined multimodal approach integrating surgery and radiation therapy (RT) with or without chemotherapy (CT) is commonly employed in advanced oral cancer to prevent recurrences and locoregional spread. Oral mucositis is a common acute toxicity reported in patients undergoing RT and CT. The delivery of optimal cancer therapy protocols is compromised due to morbidity caused by oral mucositis.

Aims:
To compare the severity of oral mucositis in oral cancer patients undergoing 3-Dimensional Conformal Radiation Therapy (3DCRT) and Intensity Modulated Radiation Therapy (IMRT) with or without concomitant CT.

Settings and Design:
This was a prospective, unicentric and longitudinal study conducted in a cancer centre.

Methods and Material:
One hundred four patients with locally advanced oral cancer were enrolled in this study. Fifty-two patients were treated with IMRT and 52 patients with 3DCRT to a dose of >60 Gy, along with concurrent cisplatin weekly CT. Mucositis was recorded before the start, in the end, 1 month, and 3 months post-chemoradiotherapy treatment.

Statistical Analysis Used:
Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) software (v. 21.0, Chicago. 2012). Descriptive and frequency statistics were performed for different parameters assessed in 3DCRT and IMRT group.

Results:
Grade 3 mucositis was the most predominant grade observed in both groups at the end of treatment. Thirty-six patients (69.3%) versus 24 patients (46.1%) developed grade 3 mucositis in 3DCRT and IMRT group, respectively (P = 0.013). Healing was better with IMRT group when compared to 3DCRT group 1 month and 3 months post-RT. Mucositis was severe in patients undergoing concomitant CT.

Conclusions:
IMRT reduced the incidence of severe mucositis and also improved the treatment-compliance compared to 3DCRT in locally advanced head neck cancer patients treated by chemoradiotherapy.