bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Characterization of Novel Diethylenetriamine Based Sulfonamide Ligands and Their Bidentate Platinum(II) Complexes Toward Anticancer Drug Leads
Authors: Theshini Perera  , Dinithi Kaluthanthiri  , Umapriyatharshini Rajagopalan  , Sameera Samarakoon  , Laksiri Weerasinghe  , Inoka C. Perera  
Published: December 2023

Diethylenetriamine (dienH) is one of the most biologically compatible chelate frameworks. Its hydrophilic amine moiety was functionalized via N-sulfonylation with sulfonyl chloride to produce two novel ligands; N(SO2)(bzd)dienH (L1) and N(SO2)(4-Mebip)dienH (L2) and two reported ligands; N(SO2)(1-nap)dienH (L3) and N(SO2)(2-nap)dienH (L4). Treatment of cis-Pt(DMSO)2Cl2with L1, L2, L3 and L4 afforded four novel neutral complexes [Pt(N(SO2)(bzd)dienH)Cl2] (C1), [Pt(N(SO2)(4-Mebip)dienH)Cl2] (C2), [Pt(N(SO2)(1-nap)dienH)Cl2] (C3) and [Pt(N(SO2)(2-nap)dienH)Cl2] (C4) respectively. All synthesized compounds were characterized by 1H NMR, UV-Vis, FTIR and fluorescence spectroscopy. Aliphatic diethylenetriamine protons of the ligands appeared in the 3.00 -2.30 ppm region in 1H NMR spectra recorded in DMSO-d6. Upon complexation, the appearance of two broad NH peaks between 5.00 -7.00 ppm region and another broad peak between 7.00-8.00 ppm confirmed the bidentatedenticity of the ligands vs tridentate. The formation of metal complexes was further supported by FTIR spectra in which the S-N stretching band for the metal complexes appears at lower wavenumbers compared to that of the corresponding free ligands. Emission spectra were recorded in methanol and intense fluorescence properties were observed in the 331-364 nm range for the ligands, whereas the corresponding Pt complexes showed quenched fluorescence. In vitro cytotoxic effects were investigatedusing sulforhodamine B assay, where L2 (< 10 μg/mL) demonstrated increased levels of cytotoxicity followed by C2 (< 25 μg/mL) and C4 (< 50 μg/mL) to non-small cell lung cancer cells in dose and time-dependent manner, with less or no cytotoxic effects to normal lung cells tested. Among the compounds tested, C1 and C3 displayed comparatively lower but more potent cytotoxic effects on lung cancer cells. Notably, these compounds did not exhibit any toxicity towards normal cells. Thus, they hold promise as lead compounds for the development of chemotherapeutic agents targeting lung cancer.
Keywords: Platinum, Sulfonamide, Biphenyl, Benzodioxan, aphthalene
AVALIAÇÃO “IN VITRO” DO AMINOFOSFITO DE COBRE® EM FUNGOS FITOPATOGÊNICOS
Authors: Maciel Terra Leonardo 
Published: December 2023

Os fosfitos são compostos à base de fósforo que atuam como indutores do sistema de defesa das plantas, ou são diretamente tóxicos aos patógenos, constituindo uma das alternativas no manejo integrado de doenças. Este trabalho avalia o efeito in vitro do Aminofosfito de Cobre® (Ubyfol) sobre os fungos fitopatogênicos: Sclerotinia sclerotiorum, Exserohilum turcicum, Fusarium oxysporum, Stenocarpella maydis. O delineamento foi inteiramente casualizado, realizado em duplicata, com 5 tratamentos e 5 repetições, constituídos das doses de 0; 0,25; 0,5; 0,75 e 1,0 L.ha-1 de Aminofosfito de Cobre®, acrescidas em meio de cultura BDA. O experimento foi realizado no Laboratório de Microbiologia das Faculdades Associadas de Uberaba (FAZU), mensurando-se o Índice de Velocidade de Crescimento Micelial (IVCM) e o Percentual de Inibição de Crescimento (PIC) micelial dos fungos. A dose de 0,25 L.ha-1 reduziu significativamente o IVCM dos fungos S. sclerotiorum e S. maydis, e apresentou valores consideráveis de PIC micelial. Os fungos E. turcicum e F. oxysporum apresentaram redução significativa do IVCM apenas a partir da dose 1,0 L.ha-1. Esse foi o primeiro estudo com a avaliação do Aminofosfito de Cobre® no controle dos fungos citados. Os resultados indicam que o uso desse produto apresenta efeito direto sobre determinados microrganismos causadores de doenças em plantas.
POTENTIAL IMPACTS OF CLIMATE CHANGE ON AGRICULTURAL PRODUCTION IN THE LONG XUYEN QUADRANGLE, VIETNAMESE MEKONG DELTA
Authors: Dinh Tran The , Nhan Nguyen Thi Thanh , Nguyen Ho 
Published: December 2023

Climate change and its impacts have become a serious and concerning global issue. The Vietnamese Mekong Delta, is identified as one of the deltas most adversely affected by climate change. This study aims to assess the potential impacts of climate change on seven major agricultural production systems in the Long Xuyen Quadrangle region within the Vietnamese Mekong Delta. Utilizing the Analytic Hierarchy Process (AHP) in conjunction with calculating climate change impact indices, the research classifies the degree of climate change impact on agriculture, aquaculture and forestry. The study results indicate that different agricultural production systems will experience varying impacts from climate change. For rice cultivation, flooding and drought are identified as the factors with the highest impact. Factors such as temperature increase, changes in rainfall and salinity intrusion have the most significant effects on aquaculture. In contrast, cultivated and natural forests in the research area are less affected by climate change. This assessment outcome could be highly valuable for policymakers in developing local agricultural development plans.
Keywords: climate change effects; land use; rice cultivation; saline intrusion.

Impacto potencial das alterações climáticas na produção agrícola no Quadrilátero Long Xuyen, Delta vietnamita do Mekong

RESUMO: As alterações climáticas e os seus impactos tornaram-se uma questão global séria e preocupante. O Delta vietnamita do Mekong é identificado como um dos deltas asiáticos mais afetados pelas alterações climáticas. Este estudo visa avaliar os impactos das alterações climáticas em sete grandes sistemas de produção agrícola na região do Quadrilátero Long Xuyen, no Delta do Mekong, Vietnã. Utilizando o Processo de Hierarquia Analítica (AHP), em conjunto com o cálculo dos índices de impacto das alterações climáticas, a investigação classifica o grau de impacto das alterações climáticas na agricultura, aquicultura e silvicultura. Os resultados do estudo indicam que diferentes sistemas de produção agrícola sofrerão impactos variados das alterações climáticas. Para o cultivo do arroz, as inundações e a seca são identificadas como os fatores de maior impacto. Fatores como o aumento da temperatura, as mudanças nas chuvas e a intrusão de salinidade têm os efeitos mais significativos na aquicultura. Em contraste, as florestas cultivadas e naturais na área de investigação são menos afetadas pelas alterações climáticas. O resultado desta avaliação poderá ser altamente valioso para as decisões políticas no desenvolvimento de planos de desenvolvimento agrícola local.
Palavras-chave: efeitos das alterações climáticas; uso da terra; cultivo de arroz; intrusão salina.
Water availability analysis of Walanae River
Authors: Lias Syamsul Arifin , Assegaf A , Sakka Sakka , Paharuddin Paharuddin , Syamsuddin E 
Published: December 2023

The Walanae Watershed plays an essential role as a water provider for irrigation and industry in the central part of South Sulawesi Province, Indonesia. The Walanae River flows through Enrekang, Soppeng, and Bone Regencies. This paper describes the availability of water in the Walanae watershed. Water discharge of the Walanae river recorded at Tampangeng station from 2000 to 2014 is analyzed using descriptive statistics to obtain a flow duration curve. The calculation results show that the available discharge is quite extensive throughout the year with a range of 16.5 m3.s–1–316 m3.s–1, and an average of 138 m3.s–1. The minimum discharge generally occurs from September to November, while the peak discharge generally occurs in January and July. The results show that water availability for 9, 10, 11 months, and all years are: 92.2 m3.s–1, 83.4 m3.s–1, 66.3 m3.s–1, and 15.8 m3.s–1, respectively.
Effect of temperature and drying time on physicochemical of beetroot (Beta vulgaris L. var. Rubra L.) flour
Authors: Prabowo Ulya Sarofa , Aprilia Rina 
Published: December 2023

Beetroot is a food source that is rich in nutrient value, including carbohydrates, minerals, vitamin C and betalains as a source of antioxidants. The high-water content causes the beetroot to be easily damaged, therefore a suitable method, is needed to preserve it. Like being processed into intermediate goods such as flour. The aim of this research was to determine the effect of temperature and drying time on the chemical characteristics and color of beetroot flour. This research used a completely randomized design (CRD) in factorial with two factors, namely the drying temperature range (50 °C, 60 °C, and 70 °C) and the drying time range (6, 7, and 8 hours). ANOVA and DMRT advanced test were used to test the resulting data. The results showed that the best treatment was obtained from sample treated a drying temperature of 50oC and a drying time of 6 hours, the yield value was 13.53%, with water content of 12.61%, ash 2.65%, fat 0.73%, protein 11, 16%, carbohydrate 72.85%, antioxidant activity 69.80%, anthocyanin 69.81 mg.100 g–1, Vitamin C 31.92 mg.100 g–1, color intensity L* 15,825, a* 7.82, b* 2.78.
EDUCAÇÃO INFANTIL: A CONTRIBUIÇÃO DA BRINCADEIRA PARA O PROCESSO DE ENSINO E APRENDIZAGEM
Authors: ARAÚJO JANAINA DE OLIVEIRA , BRINGEL MARICÉLIA FÉLIX ANDRADE 
Published: December 2023

Este estudo tem como objetivo central a investigação do processo de ensino e aprendizagem na educação infantil, com ênfase na fase inicial da vida escolar das crianças e na importância da brincadeira nesse contexto, analisamos minuciosamente como a brincadeira desempenha um papel fundamental no desenvolvimento cognitivo, emocional e social das crianças durante sua experiência na Educação Infantil. Portanto, a integração da brincadeira no currículo da educação infantil é essencial para promover um ambiente de aprendizagem rico e estimulante para as crianças, contribuindo para o seu desenvolvimento holístico. Além disso, examinamos cuidadosamente as estratégias que os educadores podem adotar para integrar a brincadeira de forma eficaz em suas práticas pedagógicas, considerando as distintas etapas de desenvolvimento das crianças. A nossa trajetória acadêmica enriqueceu o entendimento sobre a ludicidade, especialmente por meio das leituras. Esse aprendizado nos estimulou o desejo de desenvolver atividades que ampliem o processo de ensino para além do ambiente da sala de aula. Este projeto de pesquisa segue uma abordagem qualitativa e compreenderá a perspectiva das professoras que atuam com crianças de 04 e 05 anos de idade na Escola Municipal Santa Rosa, situada na cidade de Serrita-PE. Utilizamos questionários e observações detalhadas de atividades que incorporam a brincadeira como instrumento de aprendizado. Por fim, conclui que a brincadeira é uma contribuição valiosa para o processo de ensino e aprendizagem na educação infantil, fornecendo uma base sólida para o desenvolvimento integral das crianças, ou seja, no desenvolvimento cognitivo, emocional e social das crianças, incentivando a criatividade e a exploração do ambiente ao seu redor. Isso, por sua vez, estabelece uma base sólida para o desenvolvimento infantil.
Education Using Animated Videos and Leaflets on Preventing The Risk of Nomophobia in High School Adolescents
Authors: Nurhaeni Heni , Putri Clarisa Setyo , Chairani Reni 
Published: December 2023

Background: Nomophobia is an experience due to not being able to use a mobile phone. Nomophobia can be caused by excessive use of mobile phones with a duration of 3 hours/day, and most of the sufferers are junior high school students. Purpose: To describe the effectiveness of education using animated videos and leaflets on preventing the risk of nomophobia among junior high school adolescents in South Jakarta.Methods: Quasi-experimental with a pretest-posttest used in control group to determine the effectiveness of adolescent education with the risk of nomophobia at SMPN 218 Jakarta and SMP PGRI 12. The sample size was 45 respondents.Results: There was a significant difference in reducing the risk of nomophobia before and after interventions, in the intervention group with. A significant decrease also occurred between the intervention group and the control group before and after the intervention with a difference mean score (6.33 points). The difference between the two groups was substantially significant to the possibility of reducing the incidence of nomophobia in adolescents with a value of p-0.041.Conclusion: Using different educational methods, such as inviting respondents to do positive thing to reduce the perceived gadget addiction.
Modified high strength lightweight-aggregate concrete based on expanded clay: composition, structure, properties
Authors: Kaverin Kostyantin , Bondarenko Olga , Anopko Dmytro , Levkivskyi Dmytro , Antoshchuk Tetiana 
Published: December 2023

The study is devoted to the development of increased strength lightweight concrete based on Portland cement modified with a complex organo-siliceous additive containing a polycarboxylate superplasticizer and an active fine-ground siliceous component. The effect of this complex additive on the physical and chemical characteristics of the hydration and structure formation processes was investigated and it was shown that the high kinetics of the strength gain is provided by directional formation of low-basic calcium hydrosilicates, hydrogranates and plazolite, which are crystallo chemically similar to each other, and provide a dense and strength cement stone matrix.
Modification by a complex additive makes possible to obtain concrete mixes with S4 consistency while a portland cement consumption per 1m3 of not more than 330 kg, with a compressive strength of 55 MPa, watertightness up to W8, frost resistance up to F400, corrosion resistance coefficients Kc in the magnesium sulfate, sodium and ammonium solutions by 10 to 24%. The introduction of a complex additive also helps to reduce the relative shrinkage by 16 ... 19% compared to the control composition, which has a positive effect on the durability of the resulting concrete.
Digital and Clinical evaluation of temporomandibular disorders in full dentition and free end extension patients.
Authors: Adel Ahmed , Aswad Fawaz , Nusrath Muzzammil 
Published: December 2023

Background: Temporomandibular disorders (TMD) Which are a subgroup of craniofacial pain disorders involving chronic pain, dysfunction of the temporomandibular joint (TMJ), masticatory muscles and associated musculoskeletal structures of the head and neck. Pain is one of the most frequent clinical features for these TMD in addition to the clicking, limitation of mouth opening and deviation. This study aimed to evaluate Digital evaluation of the occlusal instability parameters (Disclusion Time, Occlusion Time, trajectory of force Index and Occlusal Interferences).
Method: the study including 180 patients with free end extension and full dentition (kennedy classification class I and II) their age was between (20-50) years old .they had either disc displacement or myofascial pain dysfunction syndrome according to shiffman criteria.and also examined by digital T scan.
Result: the result showed significant pain difference between free end extension and full dentition patients.
Conclusion: The trajectory of force distribution is highly variable between the two major groups, the full dentition exhibit more posterior force while The free end patients tend to establish more anterior force which lead to a series of temporomandibular disorders.
Salivary antioxidents in relation to caries severity among a group of young adults
Authors: Faris Abdel Aziz Samara , Ali Jasim Wesal 
Published: December 2023

Background: Saliva represents the body's stages of toxicological, hormonal, immunological, and markers of many infectious disease and disorders, so that it's an ideal tool for monitoring oral and systemic health.
Antioxidants help the body's defensive system by reducing oxidative stress.

Aims of the study: The study was directed to estimate the carious lesion experience (DMFS) in relation to salivary superoxide dismutase and total protein among adults by age and gender.

Materials and methods: Caries experiences was assessed according to DMFS index, after investigation eighty peoples of an age 19-22 years for both genders. Stimulated salivary samples were together and chemically assessed to detect selected salivary antioxidants (superoxide dismutase, total protein), under standardized condition. Total protein and superoxide dismutase were measured by spectrophotometric examination.

Results: With not-significant differences, total protein was found to be higher in the caries active group than in the caries free group, but salivary superoxide dismutase was the opposite. with statistically not-significant differences, females had a greater average of the salivary total protein than men, whereas men had a greater average of salivary superoxide dismutase than females. the first group (19-20 years) had a not-significant greater average salivary total protein and salivary superoxide dismutase than the second group (21-22 years).
Conclusion: Salivary superoxide dismutase is the important factor in dental caries prevention. As a result, alterations in salivary content are crucial in the development and progression of dental caries.
Osteopathic status and quality of life of healthy pregnant women
Authors: Davletshina L. T. , Nenashkina E. N. 
Published: December 2023

Introduction. A number of sequentially occurring genetically determined adaptive changes in the body of a pregnant woman accompany her from the moment of conception to the birth of a child, affecting not only physical well-being, but also mental health, thus changing the level of quality of life of a woman. Along with this, physiological changes during pregnancy can serve as a background for the formation of somatic dysfunctions, the severity and level of manifestation of which are determined by the compensatory capabilities of the pregnant woman′s body. Pregnancy as a whole is a crisis period in a woman′s life, and it is during this period that the identification of functional changes and violations of the quality of life can contribute to the prevention of complications during pregnancy. The aim of the study was to study the osteopathic status and quality of life in pregnant women at different stages of pregnancy. Materials and methods. A cross-sectional cohort study conducted in the period from January 2022 to March 2023 on the basis of the maternity department of the State Medical Hospital № 16 and the medical center «Medexpert» of Kazan included 75 somatically healthy pregnant women aged 25–35 years who are in different stages of pregnancy. The average age of the subjects was 30 ± 3,8 years at the time of observation. A unified osteopathic examination was performed in all pregnant women with the formation of an osteopathic conclusion and the quality of life was assessed according to the criteria of the SF-36 questionnaire. Results. The analysis of the results of the conducted studies demonstrated that as pregnancy progresses, somatic dysfunctions of the regional level (pelvic region (p=0,01) and thoracic region (p = 0,03) come to the fore, and indicators of the level of both physical and psychological components of the quality of life significantly decrease (p = 0,02). Conclusion. Functional changes occurring in the body of a pregnant woman not only have specifics associated with the period of pregnancy, but also serve as a background condition predisposing to the formation of somatic dysfunctions, as well as worsen quality of life indicators.
The physical development of modern children and teenagers of the Nizhny Novgorod region
Authors: Kalyuzhny E. A. , Bogomolova E. S. , Mukhina I. V. , Kurnikova A. A. , Vorobiev V. G. , Mustafin R. N. , Batsevich V. F. , Gorbacheva A. K. , Fedotova T. K. , Khomyakova I. A. 
Published: December 2023

Introduction. The physical development of the child population is traditionally one of the main indicators of its health and a marker of the social well-being of society. The total dimensions of the body are both hereditary and final effectors of long-term adaptation processes of the child′s body to the effects of the internal and external environment. The integral image of the proportions of the total body dimensions of the individualized and group orders is determined by the anthropometric habitus. The purpose of the study is to study the anthropometric habitus, characterize the intragroup features of the total body size of children and adolescents in the Nizhny Novgorod region. Materials and methods. In the cross-sectional observation in 2019–2021, 5 143 children and adolescents of the Nizhny Novgorod region aged 7–17 years old, 2 396 boys, 2 747 girls, took part. The program for observing the anthropometric indicators of students was approved by the local ethics committee of PIMU, carried out with the involvement of domestic, certified, trusted equipment. Results. The physical development of the population of children and adolescents of the Nizhny Novgorod region shows intra-group tendencies, differences by gender, in the general population array. The presence of three groups of different tempo somatotypes was shown: mesosomatic boys 58,2 % and girls 61,4 %, microsomatic boys 20,9 % and girls 19,7 %, macrosomatic boys 20,9 % and girls 20,9 %. The modern difference in the growth of physical development indicators from 7 to 17 years of age in the gradation of the tempo somatotype showed that: microsomatics increased body length by a greater percentage (by 45,8 %), whereas mesosomatics this percentage was 43,1 %, and macrosomatics 39,9 %; also, MiS increased body weight by a greater percentage (by 190,5 %), in months it is 179,9 % and in MaS 168,5 %; mesosomatics show a greater increase in the circumference of the chest (by 48,3 %), microsomatics by 43,7 %, macrosomatics by 43,5 %, variances of indicator distributions in habitus differentiation show statically significant differences (p < 0,01). Conclusion. Planned measures to monitor the anthropometric habitus should be carried out taking into account the belonging of individuals both to a certain age-sex group and to the tempo somatotype, that is necessary and sufficient condition for the successful planning and implementation of medical and preventive measures in the fields of pediatrics, hygiene, sports.
Pathophysiological aspects of microgravity and gravity therapy in cardiovascular diseases
Authors: Pereshein A. V. , Kuznetsova S. V. , Petrova D. A. , Potemina T. E. 
Published: December 2023

Deconditioning in space from gravity deprivation, the problems of the consequences of modern sedentary lifestyle, bed rest and changes observed in sedentary aging demonstrate similar mechanisms of development, which are interpreted as disorders of mechanotransduction. Tensegrity theory provides the framework for understanding how external and internal mechanical forces influence biological control at the molecular and cellular levels in conditions associated with a sharp and steady disappearance of the gravitational vector signal. Microgravity causes pathologies such as severe loss of bone density and skeletal muscle strength, loss of functional capacity of the cardiovascular system, immune system and other disorders. The effect on the human body for therapeutic and preventive purposes with various parameters of artificial gravity is a modern and highly effective technology of restorative medicine. The aim of this lecture is to summarize the most important findings about the effects of gravitational therapy in different, mainly vascular based pathologies according to literary sources.