bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is noncoplanar plan more robust to inter‐fractional variations than coplanar plan in treating bilateral HN tumors with pencil‐beam scanning proton beams?
Authors: Yi ByongYong , Jatczak Jenna , Deng Wei , Poirier Yannick P. , Yao Weiguang , Witek Matthew E. , Molitoris Jason K. , Zakhary Mark J. , Zhang Baoshe , Biswal Nrusingh C. , Ferris Matthew J. , Mossahebi Sina 
Published: November 2023

AbstractPurposeNoncoplanar plans (NCPs) are commonly used for proton treatment of bilateral head and neck (HN) malignancies. NCP requires additional verification setup imaging between beams to correct residual errors of robotic couch motion, which increases imaging dose and total treatment time. This study compared the quality and robustness of NCPs with those of coplanar plans (CPs).Methods and MaterialsUnder an IRB‐approved study, CPs were created retrospectively for 10 bilateral HN patients previously treated with NCPs maintaining identical beam geometry of the original plan but excluding couch rotations. Plan robustness to the inter‐fractional variation (IV) of both plans was evaluated through the Dose Volume Histograms (DVH) of weekly quality assurance CT (QACT) sets (39 total). In addition, delivery efficiency for both plans was compared using total treatment time (TTT) and beam‐on time (BOT).ResultsNo significant differences in plan quality were observed in terms of clinical target volume (CTV) coverage (D95) or organ‐at‐risk (OAR) doses (p > 0.4 for all CTVs and OARs). No significant advantage of NCPs in the robustness to IV was found over CP, either. Changes in D95 of QA plans showed a linear correlation (slope = 1.006, R2 > 0.99) between NCP and CP for three CTV data points (CTV1, CTV2, and CTV3) in each QA plan (117 data points for 39 QA plans). NCPs showed significantly higher beam delivery time than CPs for TTT (539 ± 50 vs. 897 ± 142 s; p < 0.001); however, no significant differences were observed for BOT.ConclusionNCPs are not more robust to IV than CPs when treating bilateral HN tumors with pencil‐beam scanning proton beams. CPs showed plan quality and robustness similar to NCPs while reduced treatment time (∼6 min). This suggests that CPs may be a more efficient planning technique for bilateral HN cancer proton therapy.
Phytic Acid‐Promoted Exfoliation of Black Phosphorus Nanosheets for the Fabrication of Photothermal Antibacterial Coatings
Authors: Wu Ziyi , Huang Tao , Sathishkumar Gnanasekar , He Xiaodong , Wu Huajun , Zhang Kai , Rao Xi , Kang En‐Tang , Xu Liqun 
Published: November 2023

AbstractMedical device‐associated infections (MDAI) caused by planktonic pathogens are of serious concern worldwide due to the emergence of drug resistance resulting from continuous overuse or misuse of antibiotics. Therefore, the design of non‐antibiotics‐based treatment for MDAI is of crucial importance. Black phosphorus (BP), a novel 2D material, has recently received much attention owing to its remarkable physical, chemical, mechanical, and functional features. However, the intricacy of the fabrication process has severely hampered the development of BP in prospective applications. In this study, a simple and eco‐friendly liquid‐phase exfoliation method of phytic acid (PA)‐promoted exfoliation of BP nanosheets (PA@BP NSs) is developed for their potential application in antibacterial photothermal therapy. To impart the antimicrobial effects, the polydimethylsiloxane surfaces are functionalized with quaternized polymer (polyquaternium‐2 or PQ) and PA@BP NSs, leading to the formation of PA‐BP‐PQ composite coatings. In addition to the contact‐killing antibacterial effect of the cationic PQ, the PA‐BP‐PQ coating exhibits remarkable near‐infrared irradiation‐triggered bactericidal effects with low cytotoxicity both in vitro and in vivo. This study proposes a simple liquid‐phase exfoliation technique for the fabrication of BP NSs and a one‐step approach for the construction of PA‐BP‐PQ composite coatings for bi‐modal (contact‐killing and photothermal) antimicrobial therapy.
Near‐Infrared Light‐Triggered Thermoresponsive Pyroptosis System for Synergistic Tumor Immunotherapy
Authors: Zhu Guoqing , Zheng Pan , Wang Man , Xie Yulin , Sun Qianqian , Gao Minghong , Li Chunxia 
Published: November 2023

AbstractPyroptosis, as an inflammatory cell death, has been widely applied in tumor therapy, but its systemic adverse reactions caused by nonspecific activation still seriously hinder its application. Herein, a near‐infrared (NIR) light‐triggered thermoresponsive pyroptosis strategy is designed for on‐demand initiation of pyroptosis and synergistic tumor immunotherapy. Specifically, glucose oxidase (GOx) loaded and heat‐sensitive material p(OEOMA‐co‐MEMA) (PCM) modified mesoporous Pt nanoparticles (abbreviated as PCMPt/GOx) are prepared as the mild‐temperature triggered pyroptosis inducer. Pt nanoparticles can not only serve as nanozyme with catalase‐like activity to promote GOx catalytic reaction, but also act as photothermal agent to achieve mild‐temperature photothermal therapy (PTT) and thermoresponsive GOx release on‐demand under the irradiation of NIR light, thereby activating and promoting pyroptosis. In vitro and in vivo experiments prove that NIR light‐triggered thermoresponsive pyroptosis system exhibits excellent antitumor immunity activity as well as significantly inhibits tumor growth. The precise control of pyroptosis by NIR light as well as pyroptosis cooperated with mild‐temperature PTT for synergistically attenuated tumor immunotherapy are reported for the first time. This work provides a new method to initiate pyroptosis on demand, which is of great significance for spatiotemporally controllable pyroptosis and immunotherapy.
Modulating Charge Separation of Oxygen‐Doped Boron Nitride with Isolated Co Atoms for Enhancing CO2‐to‐CO Photoreduction
Authors: Liang Jianli , Zhang Huabin , Song Qianqian , Liu Zheyang , Xia Jing , Yan Binhang , Meng Xiangmin , Jiang Zhifeng , Lou Xiong Wen (David) , Lee Chun‐Sing 
Published: November 2023

AbstractTo alleviate the greenhouse effect and address the related energy crisis, solar‐driven reduction of carbon dioxide (CO2) to value‐added products is considered as a sustainable strategy. However, the insufficient separation and rapid recombination of photogenerated charge carriers during photocatalysis greatly limit their reduction efficiency and practical application potential. Here, isolated Cobalt (Co) atoms are successfully decorated into oxygen‐doped boron nitride (BN) via an in situ pyrolysis method, achieving greatly improved catalytic activity and selectivity to the carbon monoxide (CO) product. X‐ray absorption fine spectroscopy demonstrates that the isolated Co atoms are stabilized by the O and N atoms with an unsaturated CoO2N1 configuration. Further experimental investigation and theoretical simulations confirm that the decorated Co atoms not only work as the real active center during the CO2 reduction process, but also perform as the electron pump to promote the electron/hole separation and transfer, resulting in greatly accelerated reaction kinetics and improved activity. In addition, the CoO2N1 coordination geometry is favorable to the conversion from *CO2 to *COOH, which shall be considered as a selectivity‐determining step for the evolution of the CO products. The surface modulation strategy at the atomic level opens a new avenue for regulating the reaction kinetics for photocatalytic CO2 reduction.
Self‐Rectifying Memristors for Three‐Dimensional In‐Memory Computing
Authors: Ren Sheng‐Guang , Dong A‐Wei , Yang Ling , Xue Yi‐Bai , Li Jian‐Cong , Yu Yin‐Jie , Zhou Hou‐Ji , Zuo Wen‐Bin , Li Yi , Cheng Wei‐Ming , Miao Xiang‐Shui 
Published: November 2023

AbstractCostly data movement in terms of time and energy in traditional von Neumann systems is exacerbated by emerging information technologies related to artificial intelligence. In‐memory computing (IMC) architecture aims to address this problem. Although the IMC hardware prototype represented by a memristor is developed rapidly and performs well, the sneak path issue is a critical and unavoidable challenge prevalent in large‐scale and high‐density crossbar arrays, particularly in three‐dimensional (3D) integration. As a perfect solution to the sneak‐path issue, a self‐rectifying memristor (SRM) is proposed for 3D integration because of its superior integration density. To date, SRMs have performed well in terms of power consumption (aJ level) and scalability (>102 Mbit). Moreover, SRM‐configured 3D integration is considered an ideal hardware platform for 3D IMC. This review focuses on the progress in SRMs and their applications in 3D memory, IMC, neuromorphic computing, and hardware security. The advantages, disadvantages, and optimization strategies of SRMs in diverse application scenarios are illustrated. Challenges posed by physical mechanisms, fabrication processes, and peripheral circuits, as well as potential solutions at the device and system levels, are also discussed.
Highly Stable Layered Coordination Polymer Electrocatalyst toward Efficient CO2‐to‐CH4 Conversion
Authors: Chen Xiao , Jia Shuaiqiang , Chen Chunjun , Jiao Jiapeng , Zhai Jianxin , Deng Ting , Xue Cheng , Cheng Hailian , Dong Mengke , Xia Wei , Zeng Jianrong , Xing Xueqing , Wu Haihong , He Mingyuan , Han Buxing 
Published: November 2023

AbstractCu2+‐based materials, a class of promising catalysts for the electrocatalytic carbon dioxide reduction reaction (CO2RR) to value‐added chemicals, usually undergo inevitable and uncontrollable reorganization processes during the reaction, resulting in catalyst deactivation or the new active sites formation and bringing great challenges to exploring their structure–performance relationships. Herein, a facile strategy is reported for constructing Cu2+ and 3, 4‐ethylenedioxythiophene (EDOT) coordination to stabilize Cu2+ ions to prepare a novel layered coordination polymer (CuPEDOT). CuPEDOT enables selective reduction of CO2 to CH4 with 62.7% Faradaic efficiency at the current density of 354 mA cm−2 in a flow cell, and the catalyst is stable for at least 15 h. In situ spectroscopic characterization and theoretical calculations reveal that CuPEDOT catalyst can maintain the Cu2+‐EDOT coordination structurally stable in CO2RR and significantly promote the further hydrogenation of *CO intermediates, favoring the formation of CH4 instead of dimerization to C2 products. The strong coordination between EDOT and Cu2+ prevents the reduction of Cu2+ ions during CO2RR. The finding of this work provides a new perspective on designing molecularly stable, highly active catalysts for CO2RR.
Spatiotemporal Immunomodulation and Biphasic Osteo‐Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration
Authors: Qiao Yusen , Yu Lei , Yang Peng , Chen Miao , Sun Haifu , Wang Lingjie , Wu Bangzhao , Oh Chun‐do , Yang Huilin , Bai Jiaxiang , Geng Dechun 
Published: November 2023

AbstractUnder diabetic conditions, blood glucose fluctuations and exacerbated immunopathological inflammatory environments pose significant challenges to periosteal regenerative repair strategies. Responsive immune regulation in damaged tissues is critical for the immune microenvironment, osteogenesis, and angiogenesis stabilization. Considering the high‐glucose microenvironment of such acute injury sites, a functional glucose‐responsive immunomodulation‐assisted periosteal regeneration composite material—PLA（Polylactic Acid）/COLI(Collagen I）/Lipo(Liposome）‐APY29 (PCLA)—is constructed. Aside from stimulating osteogenic differentiation, owing to the presence of surface self‐assembled type I collagen in the scaffolds, PCLA can directly respond to focal area high‐glucose microenvironments. The PCLA scaffolds trigger the release of APY29‐loaded liposomes, shifting the macrophages toward the M2 phenotype, inhibiting the release of inflammatory cytokines, improving the bone immune microenvironment, and promoting osteogenic differentiation and angiogenesis. Bioinformatics analyses show that PCLA enhances bone repair by inhibiting the inflammatory signal pathway regulating the polarization direction and promoting osteogenic and angiogenic gene expression. In the calvarial periosteal defect model of diabetic rats, PCLA scaffolds induce M2 macrophage polarization and improve the inflammatory microenvironment, significantly accelerating periosteal repair. Overall, the PCLA scaffold material regulates immunity in fluctuating high‐glucose inflammatory microenvironments, achieves relatively stable and favorable osteogenic microenvironments, and facilitates the effective design of functionalized biomaterials for bone regeneration therapy in patients with diabetes.
Growth analysis of Kentucky bluegrass cultivars from six classification groups
Authors: Folck Amanda J. , Bigelow Cale A. , Jiang Yiwei , Patton Aaron J. 
Published: November 2023

AbstractKentucky bluegrass (Poa pratensis L.) cultivars are diverse in their phenotype with a common classification system used to describe their growth habit but it is unclear why their growth differs. Growth analysis measurements have been used to explain growth rate differences among grass species and cultivars. The objective of this experiment was to study the growth of six commercially available Kentucky bluegrass cultivars from different growth habit classifications using classical growth analysis. Kentucky bluegrass seed was germinated and transplanted into cone‐tainers and transferred to a growth chamber maintained at 25/15°C (day/night) and a 12‐h photoperiod. Thirty plants per cultivar were used with six whole plants of each cultivar harvested 8 weeks after transplanting and once per week for the next 4 weeks for a total of five harvests. Barvette HGT produced the largest plants, and Moonlight SLT produced the smallest plants by the end of the experiment, although the relative growth rate and absolute growth rate did not vary between the cultivars. Results from the growth analysis revealed that Moonlight SLT had the highest leaf area ratio (89.4 cm2 g−1), specific leaf area (200.1 cm2 g−1), and rhizome weight ratio (0.101 g g−1), but the lowest stem weight ratio (0.120 g g−1) and root weight ratio (0.338 g g−1). Final plant weights and leaf area measurements were closely aligned with Kentucky bluegrass classification information. Unfortunately, classical growth analysis provided little insight into why some cultivars possess more aggressive growth characteristics or compact growth habits.
How mutual aid proliferation developed solidarity and sense of collective responsibility in the early months of COVID‐19
Authors: Bender Kimberly , Saavedra Kate , Milligan Tara , Littman Danielle Maude , Becker‐Hafnor Trish , Dunbar Annie Zean , Boyett Madi , Holloway Brendon , Morris Karaya 
Published: November 2023

AbstractAlthough mutual aid organizing is a social movement practice long sustained by queer/trans people, immigrants, people of color, and disability communities, among other communities pushed to the margins of society, with the emergence of the COVID‐19 pandemic, and subsequent government failures in addressing unmet needs, mutual aid proliferated into new (and more socially privileged) communities in the United States and across the world. Amidst this landscape of extraordinary and unique crises, our study sought to understand the benefits experienced by those engaged in mutual aid in the early months of the COVID‐19 pandemic in the state of Colorado, United States. Our team conducted semistructured individual interviews with 25 individuals participating in mutual aid through groups organized on social media or through intentional communities. We found that participants, who engaged in mutual aid in the early months of the COVID‐19 pandemic, built empathy, a sense of nonjudgement, and critical consciousness as they created common ground as humans. Participants also found mutual aid engagement to provide nourishing support, to hold pain among more people, and, simply to “feel good.” We discuss the potential implications of these benefits for sustaining mutual aid movements through the ongoing COVID‐19 pandemic in the United States and beyond.
Cat eye syndrome: Clinical, cytogenetics and familial findings in a large cohort of 43 patients highlighting the importance of congenital heart disease and inherited cases
Authors: Jedraszak Guillaume , Jobic Florence , Receveur Aline , Bilan Frédéric , Gilbert‐Dussardier Brigitte , Tiffany Busa , Missirian Chantal , Willems Marjolaine , Odent Sylvie , Lucas Josette , Dubourg Christele , Schaefer Elise , Scheidecker Sophie , Lespinasse James , Goldenberg Alice , Guerrot Anne‐Marie , Joly‐Helas Géraldine , Chambon Pascal , Le Caignec Cédric , David Albert , Coutton Charles , Satre Véronique , Vieville Gaëlle , Amblard Florence , Harbuz Radu , Sanlaville Damien , Till Marianne , Vincent‐Delorme Catherine , Colson Cindy , Andrieux Joris , Naudion Sophie , Toutain Jérome , Rooryck Caroline , de Fréminville Bénédicte , Prieur Fabienne , Daire Valérie Cormier , Amram Daniel , Kleinfinger Pascale , Raabe‐Meyer Gisela , Courage Carolina , Lemke Johannes , Stefanou Eunice G. , Loretta Thomaidis , Emmanouil Manolakos , Tzeli Sophia Kitsiou , Sodowska Henryka , Anderson Jasen , Nandini Adayapalam , Copin Henri , Garçon Loïc , Liehr Thomas , Morin Gilles 
Published: November 2023

AbstractCat Eye Syndrome (CES) is a rare genetic disease caused by the presence of a small supernumerary marker chromosome derived from chromosome 22, which results in a partial tetrasomy of 22p‐22q11.21. CES is classically defined by association of iris coloboma, anal atresia, and preauricular tags or pits, with high clinical and genetic heterogeneity. We conducted an international retrospective study of patients carrying genomic gain in the 22q11.21 chromosomal region upstream from LCR22‐A identified using FISH, MLPA, and/or array‐CGH. We report a cohort of 43 CES cases. We highlight that the clinical triad represents no more than 50% of cases. However, only 16% of CES patients presented with the three signs of the triad and 9% not present any of these three signs. We also highlight the importance of other impairments: cardiac anomalies are one of the major signs of CES (51% of cases), and high frequency of intellectual disability (47%). Ocular motility defects (45%), abdominal malformations (44%), ophthalmologic malformations (35%), and genitourinary tract defects (32%) are other frequent clinical features. We observed that sSMC is the most frequent chromosomal anomaly (91%) and we highlight the high prevalence of mosaic cases (40%) and the unexpectedly high prevalence of parental transmission of sSMC (23%). Most often, the transmitting parent has mild or absent features and carries the mosaic marker at a very low rate (<10%). These data allow us to better delineate the clinical phenotype associated with CES, which must be taken into account in the cytogenetic testing for this syndrome. These findings draw attention to the need for genetic counseling and the risk of recurrence.
A novel variant in CYFIP2 in a girl with severe disabilities and bilateral perisylvian polymicrogyria
Authors: Salokivi Tommi , Parkkola Riitta , Rajendran Yasmin , Bharadwaj Thashi , Acharya Anushree , Leal Suzanne M. , Järvelä Irma , Arvio Maria , Schrauwen Isabelle 
Published: November 2023

AbstractBilateral perisylvian polymicrogyria (BPP) is a structural malformation of the cerebral cortex that can be caused by several genetic abnormalities. The most common clinical manifestations of BPP include intellectual disability and epilepsy. Cytoplasmic FMRP‐interacting protein 2 (CYFIP2) is a protein that interacts with the fragile X mental retardation protein (FMRP). CYFIP2 variants can cause various brain structural abnormalities with the most common clinical manifestations of intellectual disability, epileptic encephalopathy and dysmorphic features. We present a girl with multiple disabilities and BPP caused by a heterozygous, novel, likely pathogenic variant (c.1651G>C: p.(Val551Leu) in the CYFIP2 gene. Our case report broadens the spectrum of genetic diversity associated with BPP by incorporating CYFIP2.
Diffractive Beam‐Shaping Element for Generating Multiple Structured Beams with Distinct Spatial Structures
Authors: Ebrahimi Haleh , Sabatyan Arash 
Published: November 2023

AbstractThis paper presents a novel approach for generating structured light using a diffractive beam‐shaping element that can generate multiple beams with distinct spatial structures in the focal plane. The element is constructed by restructuring a spiral zone plate with fork gratings, providing a tunable and controllable means for generating structured light. The element can create linear and 2D arrays of various structured beams, including vortices with adjustable charge and vorticity, petallike beams, and ring‐lattice structures. To control the generation of these beams, it introduces several parameters of the fork gratings, enabling tailoring of the beam properties to specific applications. The proposed approach involves significant mathematical analysis, including the derivation of complex equations and expressions to understand the behavior of the proposed element and its impact on the generated beams. It conducts simulations and experiments to validate the mathematical analysis and demonstrate the feasibility of the proposed approach.
Microsecond Timescale Conformational Dynamics of a Small‐Molecule Ligand within the Active Site of a Protein
Authors: Kotschy Julia , Söldner Benedikt , Singh Himanshu , Vasa Suresh K. , Linser Rasmus 
Published: November 2023

AbstractThe possible internal dynamics of non‐isotope‐labeled small‐molecule ligands inside a target protein is inherently difficult to capture. Whereas high crystallographic temperature factors can denote either static disorder or motion, even moieties with very low B‐factors can be subject to vivid motion between symmetry‐related sites. Here we report the experimental identification of internal μs timescale dynamics of a high‐affinity, natural‐abundance ligand tightly bound to the enzyme human carbonic anhydrase II (hCAII) even within a crystalline lattice. The rotamer jumps of the ligand's benzene group manifest themselves both, in solution and fast magic‐angle spinning solid‐state NMR 1H R1ρ relaxation dispersion, for which we obtain further mechanistic insights from molecular‐dynamics (MD) simulations. The experimental confirmation of rotameric jumps in bound ligands within proteins in solution or the crystalline state may improve understanding of host‐guest interactions in biology and supra‐molecular chemistry and may facilitate medicinal chemistry for future drug campaigns.
A semi‐supervised JITL paradigm based on manifold regularization for online soft sensor development
Authors: Zhou Junxi , Li Xu , Shao Weiming , Zhao Dongya 
Published: November 2023

AbstractJust‐in‐time learning (JITL) is often used for soft measurements of nonlinear time‐varying processes due to its desirable properties. Nevertheless, most existing JITL methods utilize only limited labeled data, ignoring abundant information of plentiful unlabeled data, which prevents the JITL‐based soft sensors from achieving the best performance. To address this issue, this paper proposes a semi‐supervised JITL paradigm based on manifold regularization, denoted as MRSsJITL. The MRSsJITL could effectively use the information of unlabeled data to make up for the deficiency of supervised JITL. Then, a weighted spatial‐temporal similarity metric is developed to calculate the relevance between samples more accurately. The performance of the MRSsJITL is assessed using both numerical example and actual industrial process. The results demonstrate that, compared with the conventional JITL approaches, the MRSsJITL can efficiently improve the predictive accuracy.