bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sugar intake on body weight: a review
Authors: Vermunt S. H. F. , Pasman W. J. , Schaafsma G. , Kardinaal A. F. M. 
Published: December 2004

SummaryWeight reduction programmes are mainly focused on reducing intake of fat and sugar. In this review we have evaluated whether the replacement of dietary (added) sugar by low‐energy sweeteners or complex carbohydrates contributes to weight reduction. In two experimental studies, no short‐term differences in weight loss were observed after use of aspartame as compared to sugar in obese subjects following a controlled energy‐restricted diet. However, consumption of aspartame was associated with improved weight maintenance after a year. In two short‐term studies in which energy intake was not restricted, substitution of sucrose by artificial sweeteners, investigated mostly in beverages, resulted in lower energy intake and lower body weight. Similarly, two short‐term studies, comparing the effect of sucrose and starch on weight loss in obese subjects did not find differences when the total energy intake was equal and reduced. An ad libitum diet with complex carbohydrates resulted in lower energy intake compared to high‐sugar diets. In two out of three studies, this was reflected in lower body weight in subjects consuming the complex carbohydrate diet. In conclusion, a limited number of relatively short‐term studies suggest that replacing (added) sugar by low‐energy sweeteners or by complex carbohydrates in an ad libitum diet might result in lower energy intake and reduced body weight. In the long term, this might be beneficial for weight maintenance. However, the number of studies is small and overall conclusions, in particular for the long term, cannot be drawn.
Pneumonitis complicating methotrexate therapy for pustular psoriasis
Authors: Ameen M , Taylor DA , Williams IP , Wells AU , Barker JNWN 
Published: December 2004

AbstractWe report a patient with pustular psoriasis who developed interstitial pneumonitis after receiving weekly methotrexate (MTX) therapy at an average dose of 20 mg for 26 years. The patient responded dramatically to withdrawal of the drug and administration of corticosteroids. Pulmonary toxicity is a rare adverse effect of MTX therapy and is particularly uncommon in psoriatics. As interstitial pneumonitis is a potentially fatal but reversible complication, early respiratory symptoms even in patients on low‐dose MTX treatment should be appropriately investigated.
Palmoplantar pustulosis: a clinicoepidemiological study. The relationship between tobacco use and thyroid function
Authors: Giménez‐García R , Sánchez‐Ramón S , Cuellar‐Olmedo LA 
Published: December 2004

ABSTRACTBackground Palmoplantar pustulosis (PPP) is a skin disease characterized by chronically recurring sterile pustules on the palms and the soles. Although the aetiology of PPP is unknown, it is interesting to note the high prevalence of tobacco use in these patients. It would seem that there may be a relationship between PPP, autoimmune diseases and alterations of thyroid function.Methods We studied a total of 17 patients with ages ranging from 28 to 67 years, diagnosed with PPP. Patients were interviewed about: autoimmune diseases, psoriasis and thyroid disease, tobacco use (classified as: A, non‐smoker; B, ex smoker; C, smoker of less than 20 cigarettes/day; D, smoker of more than 20 cigarettes/day). The patients were interviewed regarding the possible existence of a personal or family history of thyroid disease, determined using thyroid‐stimulating hormone, thyroxine, antithyroid antibodies (antimicrosomal and antithyroglobulin antibodies).Results The majority of the patients smoked cigarettes (according to classification). Of the 12 patients for whom a thyroid study was performed three had been diagnosed with thyroid diseases, an increase in thyroid‐stimulating hormone in one case and two showed an increase in antimicrosomial antibodies.Conclusions We have been able to demonstrate a high prevalence of thyroid dysfunction and tobacco use in patients with PPP.
Chronic cutaneous sclerodermoid graft‐versus‐host disease: evaluation by 20‐MHz sonography
Authors: Gottlöber P , Leiter U , Friedrich W , Bunjes D , Schulz A , Kerscher M , Peter Ru 
Published: December 2004

ABSTRACTBackground Chronic graft‐versus‐host disease (GVHD) is an immunological disorder frequently occurring as a late consequence of allogeneic bone marrow transplantation. Two variants, cutaneous lichenoid and sclerodermoid, have been described, based on clinical and histopathological examinations. It is, however, difficult to determine non‐invasively the degree of cutaneous GVHD in vivo. Ultrasonographic methods have recently provided us with the means for objective and non‐invasive monitoring of the dynamics of many chronic skin diseases.Aim, patients and methods In five patients with chronic cutaneous sclerodermoid GVHD skin thickness was measured with a 20‐MHz B‐mode ultrasound scanner (DUB 20S, taberna pro medicum, Lüneburg, Germany) in a clinically well‐defined target skin lesion. Additionally cutaneous GVHD was assessed histologically before and after treatment.Results In all patients before treatment the corium of sclerotic skin was thicker than the corresponding areas of healthy skin. The skin thickness was increased from 45% to 83%. In the subcutaneous tissue proper echo‐rich reflexes were prominent, representing the correlate of subcutaneous fibrotic trabeculae. In all patients ultrasonographic evidence of regression was shown (decrease of skin thickness by 18–83%). Moreover, it was demonstrated that quantitative assessment of skin thickness is feasible.Conclusions In this paper we describe the detailed sonographic features of cutaneous sclerodermoid GVHD for the first time. As the method is simple and non‐invasive, repeated examinations are possible. This provides the basis for monitoring treatment effects and efficient follow‐up in these chronically progressive clinical conditions after bone marrow transplantation.
Ano‐genital granulomatosis: the counterpart of oro‐facial granulomatosis1
Authors: Van De Scheur MR , Van Der Waal RIF , Van Der Waal I , Stoof TJ , Van Deventer SJH 
Published: December 2004

ABSTRACTAno‐genital granulomatosis encompasses the previously recognized clinical entities of vulvitis granulomatosa, posthitis granulomatosa, and ano‐perineitis granulomatosa. We report three patients with ano‐genital granulomatosis. The pathological features of the disease are lymphoedema and the presence of non‐caseating giant cell granulomas. These granulomas are histologically indistinguishable from those found in both Crohn's disease and sarcoidosis, therefore, patients with ano‐genital granulomatosis with accompanying gastro‐intestinal or pulmonary symptoms should be investigated for the presence of Crohn's disease or sarcoidosis, respectively. The value of ano‐genital granulomatosis as a unifying clinicopathologic concept is to provide a label for the affliction as well as to stimulate a careful search for possibly underlying systemic disorders, thus also permitting a more specific approach to therapy.
Dyskeratosis congenita associated with three malignancies
Authors: Baykal C , Kavak A , Gülcan P , Büyükbabani N 
Published: December 2004

ABSTRACTDyskeratosis congenita is a rare inheritable disorder characterized by abnormalities of the skin, nails and oral mucosa. Aplastic anaemia resulting from bone marrow hypoplasia is a frequent cause of death. Squamous cell carcinoma developing from leukoplakia and visceral malignancies are other complications of the disease. We report here a case of dyskeratosis congenita in a man who developed three neoplasias of different systems over a period of many years. Squamous cell carcinoma and gastric adenocarcinoma manifested 17 years after the man was diagnosed with Hodgkin's disease.
Acantholytic dyskeratotic naevi following Blaschko's lines: a mosaic form of Darier's disease
Authors: Gilaberte M , Puig L , Vidal D , Alomar A 
Published: December 2004

ABSTRACTDarier's disease (DD) is an autosomal‐dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Several patients with unilateral, linear, ‘zosteriform’ or localized lesions have been reported. We report three cases of DD in a localized pattern corresponding to mosaicism type 1 according to Happle's classification and review the literature about the genetic cause of DD and DD in a ‘zosteriform’ pattern.
Perforating calcific elastosis
Authors: Caldas Lopes L , Lobo L , Bajanca R 
Published: December 2004

ABSTRACTA 69‐year‐old white multiparous woman presented a reticulated yellowish patch with scattered keratotic papules on her abdomen. Histopathological examination demonstrated pseudoxanthoma elasticum (PXE)‐like changes. The diagnosis of perforating calcific elastosis (PCE) was made based on the absence of a personal and familial history of PXE. PCE is a localized acquired dermatosis and is considered to be a distinct clinical entity.
Hypertrichosis in females applying minoxidil topical solution and in normal controls
Authors: Dawber RPR , Rundegren J 
Published: December 2004

ABSTRACTBackground  Hypertrichosis has been reported more frequently in females than in males who use minoxidil topical solution (MTS) for the treatment of androgenetic alopecia (AGA). This article examines the occurrence of MTS‐induced hypertrichosis in females.Methods  Data from placebo‐controlled clinical trials in females (up to 5% MTS) were analysed based on spontaneous reports of hypertrichosis/facial hair and investigators’ inquiries (solicited) about the presence of any new hair growth on body parts other than the scalp. A postmarketing drug surveillance database for MTS was also examined for reports of hypertrichosis/facial hair.Results  In the clinical trials involving a total of 1333 females, spontaneous reports of hypertrichosis/facial hair were noted for 50 (4%) females in a dose‐related pattern of response (5% MTS > 2% MTS > placebo). Nine females (seven and two in the 5% MTS and 2% MTS groups, respectively) discontinued treatment because of hypertrichosis/facial hair. Solicited reports of excessive hair growth (primarily facial) also showed a dose‐related pattern of response. Post‐marketing data showed a lower occurrence (0.5%) of hypertrichosis/facial hair than in the clinical trials. Of interest, in one clinical trial, 27% of the females enrolled (MTS and placebo treated) had facial hair growth reported at baseline.Conclusions  Females with some hirsutism are particularly prone to seek treatment for AGA, and this may explain the high occurrence of hypertrichosis/facial hair found in the MTS clinical trials. Furthermore, some demographic groups of females are prone to develop facial hair and the problem of unwanted facial hair growth seems to be underestimated. Some females may have hair follicles that are very sensitive to MTS and should use the lowest strength of MTS (2%) to help avoid unwanted hair growth. The hypertrichotic effect of MTS on other sites than the scalp, including the face, is reversible and does not always require discontinuation of therapy.
Tufted hair folliculitis associated with pemphigus vulgaris
Authors: Jappe U , Schröder K , Zillikens D , Petzoldt D 
Published: December 2004

ABSTRACTTufted hair folliculitis (THF) is a rare disease which is characterized by the emergence of multiple hairs from widely dilated follicular orifices surrounded by an inflammatory infiltrate resulting in scarring alopecia. The pathogenesis is not yet fully understood. Although colonization with Staphylococcus aureus could not always be detected and systemic treatment with antibiotics alone is not sufficient, this microorganism is considered to play an important role. Around 30 patients with THF have been reported since the first publication. We present a patient with pemphigus vulgaris who developed THF. To our knowledge, this is the fourth case with an association of these two entities. Amongst other causing mechanisms, the autoimmune reaction may play an important role for the development of THF.
Erythema measurements may allow early diagnosis of diabetes mellitus in adult psoriatics
Authors: Avci O , Caliskan S , Caliskan M 
Published: December 2004

ABSTRACTBackground  We have observed that the erythema in subjects with psoriasis vulgaris associated with non‐insulin‐dependent diabetes mellitus (NIDDM) presents a mostly deep‐red to purple hue instead of the typical pink to red tones. We carried out a descriptive clinical study, including 141 patients with psoriasis vulgaris to quantify these colour differences.Methods  Mean erythema index values were established for the psoriatic plaques of adult subjects using an optoelectronic method. Non‐diabetic psoriatics underwent an oral glucose tolerance test (OGTT), and based on the results of the oral OGTTs, the subjects were divided into three groups: 18 psoriatics with NIDDM, 16 psoriatics with impaired glucose tolerance (IGT) and 107 psoriatics with normal glucose tolerance. The mean erythema index value was calculated for each group and the findings were compared.Results  The differences in the erythema were found to be highly significant between the group of subjects with psoriasis having normal glucose tolerance and both those with IGT and those with NIDDM (P < 0.01 and P < 0.01). The differences in the erythema were also highly significant between the psoriatic group with normal glucose tolerance and the group of 34 psoriatics with IGT and NIDDM all together (P < 0.01).Conclusions  Individuation of the various hues of erythema in psoriatics by careful dermatological examination or routine measurements of lesional erythema may alert the physician to possible IGT in the presenting subject, and this may affect disease severity.
Chronic radiodermatitis following percutaneous coronary interventions: a report of two cases
Authors: Aerts A , Decraene T , Van Den Oord JJ , Dens J , Janssens S , Guelinckx P , Flour M , Degreef H , Garmyn M 
Published: December 2004

ABSTRACTWe describe two patients in whom chronic radiodermatitis with therapy‐resistant ulceration of the right scapular region developed, following percutaneous coronary intervention with fluoroscopic imaging. Contrary to most reported cases in the literature, which involve numerous cardiac catheterization procedures, in both patients described here the total radiation dose was given during two successive procedures, involving difficult and prolonged coronary intervention with stent implantation. In both cases, local treatment of the ulcerative lesions was insufficient, necessitating excision of the radiodermatitis area and replacement with a skin graft, with good therapeutic result. The incidence of radiodermatitis after percutaneous coronary interventions is rising with the increasing number and complexity of these procedures. The main risk factor is a long duration of fluoroscopy using the same incidence. The skin lesions encompass a wide spectrum, ranging from erythema, telangiectasia, atrophy, hyperpigmentation and hypopigmentation to necrosis, chronic ulceration and squamous cell carcinoma. The lesions can appear from 15 days to 10 years after the procedure. To prevent radiation‐induced injury, the radiation dose has to be limited and monitored. Also, careful inspection of the skin at the site of exposure is necessary and the radiographic beam has to be restricted to the smallest field size. A good clinical follow‐up at regular intervals is important after long and complicated procedures.
Erythema induratum of Bazin and Poncet's disease – successful treatment with antitubercular drugs
Authors: Heinemann C , Kaatz M , Elsner P 
Published: December 2004

ABSTRACTErythema induratum of Bazin (EIB) is considered a tuberculide reaction and consists of recurrent painful nodules predominantly on the calves. Clinically it has common features with diseases like nodular vasculitis, perniosis, polyarteritis nodosa and erythema nodosum. Poncet's disease is a reactive arthritis that may accompany tuberculosis. We report a case of a young woman in which the simultaneous occurrence of erythema induratum of Bazin and Poncet's disease led to a clinical picture very similar to Löfgren's syndrome. The final diagnosis was obtained by polymerase chain reaction detection of mycobacterial DNA in a skin biopsy. A systemic therapy with tuberculostatic drugs led to the disappearance of symptoms. The presented case shows the usefulness of polymerase chain reaction diagnostics in EIB patients without other clinical signs of tuberculosis and a confusing combination of symptoms, and further confirms the presence of mycobacterial DNA in EIB lesions.
Onycholysis and subungual haemorrhages secondary to systemic chemotherapy (paclitaxel)
Authors: Ghetti E , Piraccini BM , Tosti A 
Published: December 2004

ABSTRACTPaclitaxel is a chemotherapic agent of the taxane family used in treatment of malignant solid tumory. We report here the case of a 40‐year old woman referred to our clinic for nail changes involving all 20 digits and developed after 5 months of paclitaxel intake, due to a breast carcinoma.Clinical examination revealed red‐brown discoloration of the nails associated with hematomas and onycholysis. The nail changes were very painful and the patient complained of discharge of bad‐smelling yellow brown opaque fluid from underneath the nail plate.Hemorrhagic onycholysis and subungual abscesses are a possible side effect of taxane treatment that should be early recognized to prevent serious complications.
Ingrowing nails and carbon dioxide laser surgery
Authors: Andre P 
Published: December 2004

ABSTRACTBackground Ingrown nails are common in young people, surgery is often required and recurrence rates are high.Objective To evaluate the efficacy of CO2 laser surgery.Methods Three hundred and two patients were operated with the CO2 laser under local anaesthesia.Results They were evaluated one year later: nine cases (3%) recurred and we observed 15 cases (5%) of spicules.Conclusion Ingrown nails are easily operated with the CO2 laser; bleeding is minimal, post‐operative pain is low, infection is rare, the wounds heal without exhudative drainage and cosmetic results are good.
Cutaneous melanoma extirpated with insufficient surgical margins
Authors: Serrano‐Ortega S , Ruiz‐Villaverde R , Blasco‐Melguizo J , Linares Solano J 
Published: December 2004

ABSTRACTA major controversy in the treatment of melanoma is the width of the surgical margin necessary for complete excision. We have reviewed the case histories of 1125 patients at the Melanoma Unit of the Dermatology Department of the San Cecilio Clinical Hospital in Granada from 1988 to 2000. The first aim was to verify whether there is a statistically significant correlation between occupied margins and other prognosis factors. We also analyse the situation after re‐excising the scar from the previous extirpation with a minimum margin of 1 cm.
Granuloma annulare associated with prostate carcinoma
Authors: Akyol M , Kiliçarslan H , Göze F , Emre S 
Published: December 2004

ABSTRACTGranuloma annulare occurs as an idiopathic and benign condition, although it may be associated with some neoplasms. We describe a 60‐year‐old man with granuloma annulare on dorsal hands who developed prostate carcinoma. To the best of our knowledge, this is the first case report of granuloma annulare with prostate carcinoma. Granuloma annulare, especially in older age groups, may be classified as a sign of various carcinomas.
Isolation of polymorphic microsatellite loci in Plantago major and P. intermedia
Authors: Squirrell J. , Wolff K. 
Published: December 2004

Abstract Plantago major and P. intermedia are two closely related inbreeding species. The isolation of polymorphic codominant microsatellite markers will provide valuable tools to investigate the reproductive isolation and the evolution of the two species. The isolation of microsatellite loci was achieved using a membrane enrichment method. Primers were designed to microsatellite flanking sequences and were analysed using fluorescent labels. Results indicated that nine out of the 10 loci amplified in both species, and that all the loci were polymorphic. The amplification of the loci was tested in a variety of Plantago species and was shown to be limited.
Transferability and genome specificity of a new set of microsatellite primers among Brassica species of the U triangle
Authors: Lowe Andrew J. , Jones Alexandra E. , Raybould Alan F. , Trick Martin , Moule Carolyn L. , Edwards Keith J. 
Published: December 2004

AbstractWe present a new set of 12 highly polymorphic simple sequence repeat primer sequences for use with Brassica species. These new primers, and four from A.K.S. SzewcMcFadden and colleagues, were tested in four Brassica species (B. rapa, B. napus, B. oleracea and B. nigra). Most primers successfully amplified products within all species and were polymorphic. Due to the risk of gene flow from GM oilseed rape to its wild relatives, hybrid formation in the Brassicaceae is of great interest. We identify six primer pairs as specific to the A, B or C genomes that could be used to identify such hybrids.
Polymorphic microsatellite markers for stock identification in Japanese anchovy (Engraulis japonica)
Authors: Chiu Tai‐Sheng , Lee Yann‐Jium , Huang Shiao‐Wei , Yu Hon‐Tsen 
Published: December 2004

AbstractJapanese anchovy (Engraulis japonica) is a migratory marine fish of high economic significance in Taiwan. The adult Japanese anchovies migrate from the East China sea to spawn in coastal waters of Taiwan; the larvae then drift back to the East China Sea to complete their life cycle. We developed six highly polymorphic microsatellites for E. Japonica (expected heterozygosity ranging from 0.751 to 0.971) and these microsatellites can be used as genetic markers for identifying stocks to establish regulations in fishing management. Moreover, the markers will be useful in inferring the stock origins and migration routes in the future.
Microsatellite primers for three Western AtlanticFarfantepenaeusprawn species
Authors: Maggioni R. , Rogers Alex D. 
Published: December 2004

AbstractMicrosatellite loci were identified for three closely related penaeid species,Farfantepenaeus subtilis,F. paulensisandF. sp., from genomic libraries enriched for CA repeats. Seven out of nine highly polymorphic loci detected were amplified across all three species. Between four and 64 alleles were recorded per locus (average = 36). The average observed heterozygosity ranged from 0.094 to 0.897 (mean = 0.613), while the expected heterozygosity ranged from 0.091 to 0.985 (mean = 0.822).
New microsatellites primers for plaice, Pleuronectes platessa L. (Teleostei: Pleuronectidae)
Authors: Hoarau G. , Cook D. , Stam W. T. , Olsen J. L. 
Published: December 2004

AbstractSeven microsatellite loci were developed for Pleuronectes platessa, a commercially important flatfish found throughout northern European waters. The number of alleles per locus ranged from 11 to 33 and heterozygosities from 0.74 to 0.96. Cross‐reactivity was tested against six other flatfish species. Significant amplification was found in all species from one to all seven of the loci.
Isolation and characterization of microsatellite markers from the Hypoptychus dybowskii (Pisces, Gasterosteiformes)
Authors: Munehara Hiroyuki , Nagai Noriko , Narimatsu Yoji 
Published: December 2004

Abstract Hypoptychus dybowskii (Gasterosteiformes) exhibits allopaternal care frequently caused by various types of male reproductive tactics (sneaking, egg desertion and taking over). In order to understand this interesting reproductive system, we isolated microsatellites loci from H. dybowskii. Five microsatellites showed 2–10 alleles and expected heterozygosities ranged from 0.15 to 0.84. These were not significant deviations from Hardy–Weinberg expectations. These results suggest that these novel polymorphic loci should be useful for parentage analysis of H. dybowskii.