bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan English Conversation Bagi Guru dan Siswa
Authors: Siti Maria Ulfa  , Moh. Arief Wahyudi  
Published: December 2023

This activity is carried out with the aim of conveying information about how English conversation must be carried out by both teachers and students in order to achieve the desired goals, namely being able to communicate well and effectively. The participants in this activity were three English teachers and twelfth grade students totaling thirty seven students and took place in the school’s classroom. The method used starts from introduction, delivery of theory, discussion, implementation of trials, reflection and evaluation. Each stage was well executed and as a result, this activity had a tremendous effect on teachers and students. Teachers can find strategies that they had not previously thought of in teaching speaking skills to students and they feel comfortable when they are taught by adjusting the topics of discussion that are appropriate to their domain. Therefore, it is necessary to carry out activities that are continuous and sustainable so that what is the main goal of students to be able to master English conversation for the world career and a better opportunity to study can be achieved.
Membangun Jiwa Enterpreneur Bidang Elektronika Dengan Memanfaatkan LED Strip
Authors: Kurniawan Chandra , Rida Samdara  , Riska Ekawita  
Published: December 2023

Madrasah Aliyah Mambaul Ulum merupakan salah satu madrasah swasta di bawah kementerian agama yang berlokasi di Jl. Masjid Al-Muttaqin No.92 Desa Harapan Makmur, Kecamatan Pondok Kubang, Kabupaten Bengkulu Tengah, Provinsi Bengkulu. Sekolah yang sudah berdiri sejak 2016 ini memiliki unit usaha mandiri yang keuntungannya digunakan untuk mendukung operasional sekolah seperti biaya listrik, keberlangsungan kegiatan belajar mengajar, dan pembayaran gaji guru serta tenaga kependidikan. Namun usaha yang sudah berjalan selama ini belum optimal memenuhi operasional sekolah. Berdasarkan kondisi tersebut, tim pengabdian berasumsi bahwa perlu adanya unit usaha tambahan yang dapat dijalankan oleh sekolah. Salah satu unit usaha yang belum pernah dijalankan oleh MA Mambaul Ulum adalah unit usaha berbasis elektronika berupa pemanfaatan LED (Light Emitting Diode) Strip. Pemilihan unit usaha ini berdasarkan bidang keahlian tim pengabdian yaitu bidang fisika instrumentasi (elektronika). LED Strip dijadikan sebagai bahan utama dalam pembuatan souvenir berupa lampu hias dan lampu akrilik yang bernilai jual. Souvenir berbasis LED Strip tersebut diharapkan mampu menarik minat pasar dan menjadikannya sebagai sarana promosi unit usaha sekolah. Metode yang dilaksanakan dalam mencapai tujuan adalah pelatihan dan pendampingan pembuatan souvenir. Kegiatan ini diikuti oleh 12 orang peserta siswa/i MA Mambaul Ulum yang tergabung dalam 4 kelompok kecil. Di akhir pelatihan, peserta mampu membuat souvenir berbasis LED yang telah dikustomisasi sesuai dengan kreativitas masing-masing siswa.
Application of X-ray Fluorescence and Radiation Methods for the Analysis of Medicinal Plant Raw Materials on the Example of <i>Achilleae millefolii herba</i>
Authors: Kalikina I. Yu. , Turyshev A. Yu. , Belonogova V. D. , Kuritsyn A. V. , Puchnina S. V. , Buzmakova N. A. 
Published: December 2023

Introduction. Environmental monitoring is an important area of modern scientific research. This is due to the anthropogenic impact on the environment, which often negatively affects the diversity of the Russian medicinal flora. The use of modern instrumental analytical methods of medicinal plant raw materials is relevant due to the intensive development of science. The content of heavy metals, the elemental composition and the level of background radiation are important characteristics of ecological purity and safety of medicinal plant raw materials. These characteristics are of interest for assessing the possibility of harvesting and using medicinal plants at localization. The generally accepted instructions for harvesting were used.Aim. Investigation of the possibilities of using X-ray fluorescence and radiation methods for environmental monitoring of medicinal plant raw materials.Materials and methods. The research object was Achilleae millefolii herba. The harvestment of plant raw materials was carried out in the Bardymsky, Chernushinsky, Uinsky, Kishertsky, Oktyabrsky, Suksunsky, Ordinsky, Sivinsky districts of the Perm Region in the summer in 2022–2023. The X-ray fluorescence analyzer (XFA) ARL QUANT'X EDXRF was used to determine heavy metals and assess the elemental composition of plants. The analysis was carried out according to the methodology that was developed by scientists of the Pharmacognosy Department at the Perm State Pharmaceutical Academy. The radiation background in raw materials was assessed by using a special dosimeter RADEX RD1503.Results and discussion. As a result, it was found that harvesting of Achilleae millefolii herba is possible in the Perm Region studied areas. Bardymsky, Uinsky, Kishertsky, Ordinsky, Chernushinsky districts are the most recommended for harvesting plant raw materials. Samples from these areas are ecological purity and safe for use as medicinal raw materials and have a diverse elemental composition. The content of heavy metals does not exceed the maximum permissible concentrations according to the regulatory documentation requirements. The background radiation level does not exceed the threshold value compared to other areas in the Russian Federation.Conclusion. X-ray fluorescence analysis is a suitable and reliable analytical method for determining elements in plant raw materials. XFA is a multi-element express method that allows analyzing a sample with minimal sample preparation. The advantages of the method are good reproducibility, high sensitivity, and efficiency. Research continues.
Development of Methods for Identifying BAS Exhibiting Anticoagulant Activity
Authors: Berezina E. S. , Nepogodina E. A. , Sobin F. V. , Pulina N. A. , Dozmorova N. V. 
Published: December 2023

Introduction. Vascular pathologies associated with thromboembolism are common complications and the leading cause of morbidity and mortality among patients of various nosological groups. Previously, we obtained water-soluble 2-hydroxy-4-oxo-4-R-2-butenoates of hetarylammonium, which exhibit a significant pharmacological effect on the blood coagulation system». A compound with a pronounced anticoagulant effect was found in various routes of administration. It was of interest to study various methods of confirming the authenticity of a potential anticoagulant.Aim. Development of methods for identification of a potential anticoagulant 2-hydroxy-4-oxo-(4-chlorophenyl)-2-butenoate of thiazolinammonium.Materials and methods. The studies were carried out on three series of the substance 2-hydroxy-4-oxo-(4-chlorophenyl)-2-butenoate of thiazolinammonium obtained in laboratory conditions. The melting point of BAS was measured by the capillary method according to GF XV OFS.1.2.1.0011 "Melting point". The solubility of the substance was determined in accordance with GF XV of the OFS.1.2.1.0005 "Solubility". The absorption spectra in the IR region were taken in accordance with GF XV of the OFS.1.2.1.1.0002 "Spectrophotometry in the middle infrared region". Absorption spectra in the UV region were taken in accordance with GF XV of the OFS.1.2.1.1.0003 "Spectrophotometry in the ultraviolet and visible regions". In carrying out qualitative reactions, reagents prepared in accordance with GF XV of the OFS were used.1.3.0001 "Reagents. Indicators".Results and discussion. A description of the substance has been carried out. The melting point and solubility of the compound were determined. Spectra in the IR and UV regions of the spectrum were taken. Methods were selected, and qualitative reactions of authenticity of a potential anticoagulant were carried out.Conclusion. The studied characteristics of the new BAS can be used in the standardization of the substance according to the indicators "Description", "Solubility", "Identification", "Melting point". These indicators characterize the physico-chemical properties of 2-hydroxy-4-oxo-(4-chlorophenyl)-2-butenoate of thiazolinammonium, and will be included in the draft regulatory documentation for the substance in the future.
Study of the Anti-inflammatory Activity of 2-hydroxy-4-oxo-4-R-2-butenoates of Heterylammonium, which Have an Effect on the Blood Clotting System
Authors: Sobin F. V. , Pulina N. A. , Chashchina S. V. , Starkova A. V. , Rudakova I. P. , Buzmakova N. A. 
Published: December 2023

Introduction. The use of anticoagulants is relevant in therapeutic, cardiological, neurological practice, geriatrics, obstetrics and gynecology, as well as in complications associated with COVID-19 infection and vaccination. In-depth studies of additional pleiotropic effects of existing anticoagulants are being conducted. The anti-inflammatory effect of heparins and direct oral anticoagulants was found. Special emphasis is placed on the existing close relationship between coagulation and inflammatory processes. The interaction of anticoagulants with nonsteroidal anti-inflammatory drugs when taken together is actively discussed. The combination of anticoagulant and anti-inflammatory action in one chemical molecule can solve the problem of polypragmasia.Aim. To study the anti-inflammatory activity of promising 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium, which have an effect on the blood clotting system.Materials and methods. For further study of anti-inflammatory activity, 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium, which have an effect on the blood clotting system, were selected. The anti-inflammatory effect was studied on a model of acute inflammatory edema in mongrel rats of both sexes weighing 180–250 g. The studied compounds were administered intragastrically. Diclofenac sodium and nimesulide substances administered similarly were used as comparison drugs. Acute toxicity of substances that showed activity was studied on white nonlinear mice of both sexes weighing 18–22 g with the definition of LD50.Results and discussion. All the studied 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium have anti-inflammatory effects of varying severity. Data on the study of acute toxicity during intragastric administration, allow us to attribute the studied compounds to the 4.5 class of the hazard classification of chemical products.Conclusion. The anti-inflammatory activity of 14 2-hydroxy-4-oxo-4-R2-butenoates of heterylammonium has been studied. Five butanoate have an effect lower than comparison drugs, eight compounds are comparable to the effect of reference drugs, one compound is superior to nimesulide. The studied compounds can be assigned to class 4,5 of the hazard classification of chemical products. Medicinal candidates have been selected for further pharmacological, toxicological and technological study.
Synthesis and Antihypoxic Activity of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic Acids and Their Reaction Products with Substituted Hydrazines
Authors: Namyatova K. V. , Zykova S. S. , Ovchinnikov D. S. , Shurov S. N. 
Published: December 2023

Introduction. Hypoxia is a violation of oxidative processes in tissues that occur when oxygen is insufficiently supplied to them or when its utilization is disrupted during biological oxidation. Chronic hypoxic damage plays an important role in the occurrence and development of various diseases, which necessitates the synthesis of new compounds with antihypoxic activity.Aim. The purpose of this study is to synthesize and investigate the antihypoxic activity of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids and their reaction products with substituted hydrazines.Materials and methods. 2-Aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids (I–VI) were obtained with high yields as a result of the interaction of 4-aroyl-2,4-dioxobutane acids with 3-amino-5,5-dimethylcyclohex-2-enone. Interaction of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids with benzyl- and (2-phenylethyl)hydrazines 5-aryl-2-benzyl- and 2-(2-phenylethyl)-8,8-dimethyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]cinnoline-3-ones (VII–XII) were obtained. As a result, 12 compounds were synthesized. The study of the antihypoxic activity of the obtained compounds was carried out in vivo on a model of normobaric hypoxia with hypercapnia.Results and discussion. The synthesized compounds were tested for the presence of antihypoxic action. The most pronounced antihypoxic activity is characteristic of compounds VI and VIII, which have a methoxy group and a methyl radical in the para-position of the phenyl substituent at C5, respectively. The presence of chlorine in the structure of compound III, fluorine in compound X and the absence of substituents (compounds I and VII) contribute to the prohypoxic effect. According to the results of the study, both quinolincarboxylic acids and pyridocinnolines are potential antihypoxants.Conclusion. A comparative analysis of the antihypoxic activity of the synthesized compounds was carried out, the relationship between their structure and severity of action was established, the most active substances were identified.
The Effect of New Water-soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates on the Hemostasis System <i>In vitro</i>
Authors: Starkova A. V. , Sobin F. V. , Rudakova I. P. , Pulina N. A. , Dozmorova N. V. , Luzhanin V. G. 
Published: December 2023

Introduction. The hemostasis system is a set of functional, morphological and biochemical mechanisms of a living organism that ensure the preservation of the liquid state of the blood, the prevention and stopping of bleeding, as well as the integrity of blood vessels. Anticoagulants and hemostatic agents can significantly change the mechanism of hemostasis. Interest in the synthesis and search for compounds that affect the blood coagulation system remains high. Substances exhibiting anticoagulant and hemostatic effects have been found. The search for compounds among the products of organic synthesis that affect the hemostasis system seems relevant.Aim. To study the effect of new water-soluble 2-amino heteryl-3-ium 4-(get)aryl-2-hydroxy-4-oxobut-2-enoates on the hemostasis system using an in vitro model.Materials and methods. Direct interaction 4-(het)aryl-2-hydroxy-4-oxobut-2-enoic acids with heterocyclic amines have been obtained new water soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates. The study of the effect of substances on the hemostasis system was carried out using the coagulometer "APK 4-02-P". Ethamsylate and sodium heparin were used as comparison drugs for hemostatic and anticoagulant activity, respectively. Acute toxicity of the compounds was determined by intravenous administration of aqueous solutions of the compounds to non-linear white mice of both sexes with the definition of LD50.Results and discussion. 10 New 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates have been synthesized. In vitro screening of the effect of compounds on the hemostasis system found that 3 substances have a pronounced anticoagulant effect, and 4 compounds showed hemostatic activity. Some patterns of the "structure-pharmacological action" relationship have been found. The studied butenoates can be classified as moderately toxic compounds according to the classification of chemical toxicity.Conclusion. Pharmacological screening in vitro of the effect of compounds on the hemostasis system was carried out. It was found that all the studied compounds have an effect on the blood coagulation system of varying degrees of severity. The combination of a pronounced pharmacological effect, low acute toxicity and water solubility of butenoates may become a prerequisite for further search and possible development of new domestic medicines that have an effect on the hemostasis system.
UNMASKING FRAUDSTERS: Ensemble Features Selection to Enhance Random Forest Fraud Detection
Authors: Akazue Maureen Ifeanyi , Debekeme Irene Alamarefa , Edje Abel Efe , Asuai Clive , Osame Ufuoma John 
Published: December 2023

Fraud detection is used in various industries, including banking institutes, finance, insurance, government agencies, etc. Recent increases in the number of fraud attempts make fraud detection crucial for safeguarding financial information that is confidential or personal. Many types of fraud problems exist, including card-not-present fraud, fake Marchant, counterfeit checks, stolen credit cards, and others. An ensemble feature selection technique based on Recursive feature elimination (RFE), Information gain (IG), and Chi-Squared (X2) in concurrence with the Random Forest algorithm, was proposed to give research findings and results on fraud detection and prevention. The objective was to choose the essential features for training the model. The Receiver Operating Characteristic (ROC) Score, Accuracy, F1 Score, and Precision are used to evaluate the model's performance. The findings show that the model can differentiate between fraudulent transactions and those that are not, with an ROC Score of 95.83% and an Accuracy of 99.6%. The F1 Score of 99.6%% and precision of 100% further sustain the model's ability to detect fraudulent transactions with the least false positives correctly. The ensemble feature selection technique reduced training time and did not compromise the model's performance, making it a valuable tool for businesses in preventing fraudulent transactions.
El TDAH en Niños y las Técnicas de Intervención en la Terapia Cognitivo Conductual: Revisión Documental entre 2014 y 2021
Authors: Guzmán Pacheco Juan Felipe , Jiménez Blanco Karen Dayanna , Rueda Gómez Yulieth Maritza , Prada Rodríguez Aduin Alexander 
Published: December 2023

El TDAH es un trastorno con alta prevalencia en población infantil, conllevando desde la psicología, a implementación de tratamientos con importante nivel de eficacia. Se planteó como propósito investigativo describir las técnicas de intervención de la terapia cognitivo conductual en el tratamiento del TDAH en niños. Se encontraron 77 documentos; luego de aplicar criterios de inclusión y exclusión se seleccionaron en total 53, siendo de tipo científico como artículos e informes de investigación. Metodológicamente se plantea un paradigma cualitativo, diseño documental, alcance descriptivo, mediante revisión documental entre los años 2014 a 2021. Una de las limitaciones observadas fue, que no se encontraron suficientes artículos de tipo científico. Se halló que el TDAH es definido a través de tres bases teóricas como la neurobiológica, la neuroconductual y la de los trastornos comórbidos, en las cuales se aplica el uso de ciertas técnicas específicas para su tratamiento.
The Prevalence of Trichuriasis in School-age Children in Asia: A Systematic Review
Authors: Purba Ivan Elisabeth , Girsang Vierto Irennius , Amila Amila , Wandra Toni 
Published: December 2023

Introduction: Trichuris trichiura, hookworms, and Ascaris lumbricoides are known as soil-transmitted helminths that commonly infect humans. Transmission is more common in areas with poor personal hygiene and environmental sanitation. Objectives: The aim of this study was to determine available information on the prevalence of T. trichiura infection in school-age children in Asia. This information can be used for additional studies to evaluate the prevalence and risk factors for T. trichiura infection locally that can inform regional control programs and look at laboratory examination techniques to diagnose this parasite disease. Methods: Multiple databases (Web of Science, PubMed, ProQuest, Scopus, and Google Scholar) were searched for literature on the trichuriasis prevalence published from 2011 to January 2021. Results: A total of 13,836 studies were identified through database searches. The included studies represent 16 countries, with the highest number of study conducted in Yemen. Conclusions: The prevalence of trichuriasis in school-age children was found to vary widely by country. The Kato-Katz technique was commonly used to detect T. trichiura eggs in school-age children in Asia. Health sector should implement surveillance programs, particularly in countries with high infection prevalence. Educational programs aimed at improving personal hygiene and environmental sanitation to decrease trichuriasis transmission.
ProvGRP: A Context-Aware Provenance Graph Reduction and Partition Approach for Facilitating Attack Investigation
Authors: Li Jiawei , Zhang Ru , Liu Jianyi 
Published: December 2023

Attack investigation is a crucial technique in proactively defending against sophisticated attacks. Its purpose is to identify attack entry points and previously unknown attack traces through comprehensive analysis of audit data. However, a major challenge arises from the vast and redundant nature of audit logs, making attack investigation difficult and prohibitively expensive. To address this challenge, various technologies have been proposed to reduce audit data, facilitating efficient analysis. However, most of these techniques rely on defined templates without considering the rich context information of events. Moreover, these methods fail to remove false dependencies caused by the coarse-grained nature of logs. To address these limitations, this paper proposes a context-aware provenance graph reduction and partition approach for facilitating attack investigation named ProvGRP. Specifically, three features are proposed to determine whether system events are the same behavior from multiple dimensions. Based on the insight that information paths belonging to the same high-level behavior share similar information flow patterns, ProvGRP generates information paths containing context, and identifies and merges paths that share similar flow patterns. Experimental results show that ProvGRP can efficiently reduce provenance graphs with minimal loss of crucial information, thereby facilitating attack investigation in terms of runtime and results.