bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of high-speed rail on SO2 emissions—based on spatial difference-in-differences analysis
Authors: Yan Na , Sun Youshuai , Lin Shanlang , Wang Jingxian , Wu Tuolei 
Published: December 2023

AbstractSO2 emissions have brought serious hidden danger to human health and environmental quality, thus hindering sustainable economic development. The development of high-speed rail indirectly has an important impact on SO2 emissions through its economic effects. Controlling SO2 emissions from the source has increasingly become the focus of many scholars, and it is very important to assess the environmental effects of high-speed rail on SO2 emissions reduction. We use the panel data of 285 cities in China from 2007 to 2017, and adopt the spatial Difference-in-Differences model to study the impact of the opening of high-speed rail on SO2 emissions. We also introduce an improved spatial DID model that distinguishes neighboring treatment groups and neighboring control groups to test the spatial spillover effect of high-speed rail on neighboring heterogeneous samples. We find that the opening of high-speed rail significantly reduces the city’s SO2 emissions through the internal accumulation effect of technological innovation and industrial structure optimization and the urban external interaction mechanism of the cross-regional flow of production factors. Moreover, the spatial spillover effect of the opening of high-speed rail on neighboring cities is significantly positive, especially the spatial spillover effect of HSR on SO2 emissions from neighboring cities without HSR. In addition, heterogeneity analysis shows that the effect varies with the different cities’ tiers and income levels. These findings are conducive to accurately assessing the environmental effects of high-speed rail, and provide important policy references for achieving sustainable development and reducing SO2 emissions.
Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study
Authors: Negishi Yoshifumi , Kaneko Haruka , Aoki Takako , Liu Lizu , Adili Arepati , Arita Hitoshi , Hada Shinnosuke , Momoeda Masahiro , Huang Hui , Tomura Jun , Wakana Suguru , Shiozawa Jun , Kubota Mitsuaki , Someya Yuki , Tamura Yoshifumi , Aoki Shigeki , Watada Hirotaka , Kawamori Ryuzo , Negishi-Koga Takako , Okada Yasunori , Ishijima Muneaki 
Published: December 2023

AbstractWe reported that the full-length width of medial tibial osteophytes comprising cartilage and bone parts correlates with medial meniscus extrusion (MME) in early-stage knee osteoarthritis (OA). However, no data exist on the prevalence of MME and its relationship with osteophytes in the elderly population. 1191 elderly individuals (females 57%; 72.9 years old on average) in the Bunkyo Health Study underwent standing plain radiograph and proton density-weighted MRI on knee joints. MRI-detected OA changes were evaluated according to the Whole-Organ Magnetic Resonance Imaging Score. A new method of assessing the cartilage and bone parts of osteophytes was developed using pseudo-coloring images of proton density-weighted fat-suppressed MRI. Most subjects showed Kellgren-Lawrence grade 1 or 2 radiographic medial knee OA (88.1%), MME (98.7%, 3.90 ± 2.01 mm), and medial tibial osteophytes (99.3%, 3.27 ± 1.50 mm). Regarding OA changes, MME was closely associated with the full-length width of medial tibial osteophytes (β = 1.114; 95% CI 1.069–1.159; p < 0.001) in line with osteophyte width (intraclass correlation coefficient, 0.804; 95% CI 0.783–0.823). Our data revealed that MME and medial tibial osteophytes are observed in the elderly and demonstrate that the degree of MME is consistent with the full-length width of medial tibial osteophytes, suggesting that osteophytes might be implicated in MME.
Development of four-bar polycentric knee joint with stance-phase knee flexion
Authors: Phoengsongkhro Santiphap , Tangpornprasert Pairat , Yotnuengnit Pattarapol , Samala Manunchaya , Virulsri Chanyaphan 
Published: December 2023

AbstractA conventional 4-bar polycentric knee and solid ankle cushion heel foot (SACH foot) have been commonly used in developing countries. However, they cannot perform stance-phase knee flexion, which makes a person with an amputation walk unnaturally and with less stability. This research proposes a novel design of a 4-bar polycentric knee with stance-phase knee flexion ability (4BSF), which can perform both stance and swing-phase knee flexion, like able-bodied gait. In the proposed conceptual design, the instantaneous center of rotation (ICR) path is repositioned during the stance phase. The ICR was placed in front of the ground reaction force (GRF) to initiate knee flexion during the loading response. The prototype was validated by a single-subject pilot study at the Gait analysis laboratory. The results showed that a person with an amputation walks with stance-phase knee flexion using the proposed 4BSF. The maximum knee flexion angle is more than 10° during the stance phase. Furthermore, when the 4BSF was used with a SACH foot, the amount of time to achieve the foot flat was shorter, and the foot flat duration time was twice as long as the conventional 4-bar polycentric knee.
An anomaly detection method for identifying locations with abnormal behavior of temperature in school buildings
Authors: Wickramasinghe Ashani , Muthukumarana Saman , Schaubroeck Matt , Wanasundara Surajith N. 
Published: December 2023

AbstractTime series data collected using wireless sensors, such as temperature and humidity, can provide insight into a building’s heating, ventilation, and air conditioning (HVAC) system. Anomalies of these sensor measurements can be used to identify locations of a building that are poorly designed or maintained. Resolving the anomalies present in these locations can improve the thermal comfort of occupants, as well as improve air quality and energy efficiency levels in that space. In this study, we developed a scoring method to identify sensors that shows collective anomalies due to environmental issues. This leads to identifying problematic locations within commercial and institutional buildings. The Dynamic Time Warping (DTW) based anomaly detection method was applied to identify collective anomalies. Then, a score for each sensor was obtained by taking the weighted sum of the number of anomalies, vertical distance to an anomaly point, and dynamic time-warping distance. The weights were optimized using a well-defined simulation study and applying the grid search algorithm. Finally, using a synthetic data set and the results of a case study we could evaluate the performance of our developed scoring method. In conclusion, this newly developed scoring method successfully detects collective anomalies even with data collected over one week, compared to the machine learning models which need more data to train themselves.
Reduced period from follicular wave emergence to luteolysis generated greater steroidogenic follicles and estrus intensity in dairy cows
Authors: Minela T. , Gibb P. , McBeth S. , Santos A. , Pursley J. R. 
Published: December 2023

AbstractThe onset of productive life in dairy cattle, concomitant to parturition, is accompanied by a substantial decrease in fertility in comparison with non-lactating, nulliparous heifers. Follicular growth patterns differ between parous and nulliparous dairy cattle. Nulliparous heifers ovulate follicles with reduced antral age (RAA). This study aimed to exogenously reduce ovulatory follicle age in lactating dairy cows from 7 to 5 days old. Cows (n = 80) had their estrous cycles synchronized with the Double-Ovsynch program. At the final portion of this program, luteolysis was induced at either 5 (RAA) or 7 (Control) days following follicular wave emergence. RAA outcomes were estimated in comparison with Controls. RAA resulted in smaller follicles 2 days post-treatment. Despite lower serum concentrations of 17β-estradiol before treatment compared with Controls, the rate of increase in this hormone was greater for the RAA treatment. There was no difference in luteolysis rates between treatments. Proestrus (luteolysis onset to estrus onset) was prolonged in RAA cows. Cows with RAA had more intense estruses. Collectively, these results indicate that decreasing the age of the ovulatory follicle may improve the steroidogenic capacity of the dominant follicle and estrus expression intensity in lactating dairy cows.
The application of machine learning approaches to determine the predictors of anemia among under five children in Ethiopia
Authors: Kebede Kassaw Abdulaziz , Yimer Ali , Abey Wondwosen , Molla Tibebu Legesse , Zemariam Alemu Birara 
Published: December 2023

AbstractHealth professionals need a strong prediction system to reach appropriate disease diagnosis, particularly for under-five child with health problems like anemia. Diagnosis and treatment delay can potentially lead to devastating disease complications resulting in childhood mortality. However, the application of machine learning techniques using a large data set provides scientifically sounded information to solve such palpable critical health and health-related problems. Therefore, this study aimed to determine the predictors of anemia among under-5 year’s age children in Ethiopia using a machine learning approach. A cross-sectional study design was done using the Ethiopian Demographic and Health Survey 2016 data set. A two-stage stratified cluster sampling technique was employed to select the samples. The data analysis was conducted using Statistical Package for Social Sciences/SPSS version 25 and R-software. Data were derived from Ethiopian Demographic and Health Survey. Boruta algorism was applied to select the features and determine the predictors of anemia among under-5 years-old children in Ethiopia. The machine learning algorism showed that number of children, distance to health facilities, health insurance coverage, youngest child’s stool disposal, residence, mothers’ wealth index, type of cooking fuel, number of family members, mothers’ educational status and receiving rotavirus vaccine were the top ten important predictors for anemia among under-five children. Machine-learning algorithm was applied to determine the predictors of anemia among under- 5 year’s age children in Ethiopia. We have identified the determinant factors by conducting a feature importance analysis with the Boruta algorithm. The most significant predictors were number of children, distance to health facility, health insurance coverage, youngest child’s stool disposal, residence, mothers’ wealth index, and type of cooking fuel. Machine learning model plays a paramount role for policy and intervention strategies related to anemia prevention and control among under-five children.
Developing a new multi-featured chitosan-quinoline Schiff base with potent antibacterial, antioxidant, and antidiabetic activities: design and molecular modeling simulation
Authors: Abdel-Baky Yasser M. , Omer Ahmed M. , El-Fakharany Esmail M. , Ammar Yousry A. , Abusaif Moustafa S. , Ragab Ahmed 
Published: December 2023

AbstractA new chitosan Schiff base was developed via the reaction of chitosan (CH) with 2-chloro-3-formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and morphology of CHQ derivative was confirmed by 1H NMR, FT-IR spectroscopy and SEM analysis. The antibacterial activity was considerably promoted with increasing quinoline concentration up to 1 M with maximal inhibition reached 96 and 77% against Staphylococcus haemolyticus and Escherichia coli, respectively. Additionally, CHQ derivative afforded higher ABTS·+ radical scavenging activity reached 59% compared to 13% for native chitosan, approving its acceptable antioxidant activity. Moreover, the developed CHQ derivative can stimulate the glucose uptake in HepG-2 and yeast cells, while better inhibition of α-amylase and α-glucosidase was accomplished with maximum values of 99.78 and 92.10%, respectively. Furthermore, the molecular docking simulation clarified the binding mode of CHQ derivative inside the active site of α-amylase and α-glucosidase, suggesting its potential use as diabetes mellitus drug. The DFT calculations indicated an improvement in the electronic properties of CHQ with a lower energy band gap reached 4.05eV compared to 5.94eV for CH. The cytotoxicity assay revealed the safety of CHQ towards normal HSF cells, hypothesizing its possible application as non-toxic antibacterial, antioxidant, and antidiabetic agent for biomedical applications.
Drug monomers from Salvia miltiorrhiza Bge. promoting tight junction protein expression for therapeutic effects on lung cancer
Authors: Zhu Guanghui , Li Daorui , Wang Xueqian , Guo Qiujun , Zhao Yuanchen , Hou Wei , Li Jie , Zheng Qi 
Published: December 2023

AbstractSalvia miltiorrhiza Bge. is a traditional Chinese medicine (TCM) that has been used for treatment of various diseases, including cancer by activating blood circulation and removing blood stasis. Tanshinone (TanIIA) and cryptotanshinone (CPT) are major lipophilic compounds extracted from the root of Salvia miltiorrhiza Bge., which are considered to be the effective compounds affecting the efficacy of the anti-tumor therapy of Salvia miltiorrhiza Bge. We have explored the mechanism of CPT and TanIIA exerting inhibition in non-small cell lung cancer (NSCLC) to provide experimental data support for guiding the translational development and clinical application of anti-tumor components of TCM. The subcutaneous tumor model and in vitro culture model of A549 cells was constructed to evaluate CPT and TanIIA's tumour-inhibitory effect respectively. RNA sequencing (RNA-seq) and bioinformatics analysis were conducted to identify differentially expressed genes (DEGs) and signalling pathways related to CPT and TanIIA treatment. qRT-PCR and Western blot were used to explore the mechanism of CPT and TanIIA intervention on NSCLC. Both CPT and TanIIA significantly inhibited the proliferation of A549 tumor cells and tumor growth in animal models. After intervention, the migration ability decreased and the level of apoptosis increased. RNA-seq results showed that both CPT and TanIIA could cause gene differential expression, miR-21-5p as one of the most significant gene expression differences between the two groups, and could act on cell connectivity. CPT and TanIIA play a regulatory role in regulating tight junction proteins (Occludin and ZO1), and Occludin mRNA and protein levels were reduced in an in vitro miR-21-5p overexpression A549 cell model. The mechanisms may be related to the reduction of miR-21-5p expression to increase the level of promoted tight junction protein expression for the purpose of inhibiting proliferation and invasion of NSCLC.
DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management
Authors: Ndetei David M. , Mutiso Victoria , Musyimi Christine , Momanyi Reinpeter , Nyamai Pascalyne , Tyrer Peter , Mamah Daniel 
Published: December 2023

AbstractLittle is known about the prevalence of Conduct Disorder (CD) and symptoms of CD in high risk psychosis persons at both clinical and community populations in LMICs and in particular Kenya. This study aimed to document (1) the prevalence of CD diagnosis and symptoms in youth who screened positive for psychosis and (2) the associated mental disorders and substance use in the same cohort in LMIC. The sample size was 536 students who had screened positive on the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) from a population of 9,742 high school, college and university students, but had not converted to a psychotic disorder. We collected data on socio-demographic characteristics and used the following tools: Economic indicators tool; the Diagnostic Interview Schedule (DIS) tool for DSM-5 diagnosis; World Health Organization (WHO) Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). Basic descriptive statistics, chi-square test, Fisher's exact test, Pearson correlation and Poisson regression were conducted. Five percent (5%) of the respondents met the criteria for DSM-5 CD. Indeterminate CD comprised 10.1%. Male gender, all substances except hallucinogens lifetime, obsessive compulsive disorder, psychosis, agoraphobia, social phobia, drug abuse/dependence, antisocial personality disorder, oppositional defiant disorder, suicidality, WERCAP screen for bipolar disorder and WERCAP screen for schizophrenia were significantly (p < 0.05) associated with CD. Deceitfulness or theft criteria symptoms showed that CD had no significant gender difference. Criteria symptoms in aggression to people and animals, destruction of property and serious violations of rules were more common among males. Our findings suggest the need to screen for and diagnose CD, mental disorders and substance use in high risk psychosis youths in Kenya. This will inform integrated management.
A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease
Authors: Liao En-Chih , Yu Ching-Hsiang , Lai Jian-Han , Lin Ching-Chung , Chen Chih-Jen , Chang Wen-Han , Chien Ding-Kuo 
Published: December 2023

AbstractHelicobacter pylori (H. pylori) infection can lead to various digestive system diseases, making accurate diagnosis crucial. However, not all available tests are equally non-invasive and sensitive. This study aimed to compare the efficacy of non-invasive and invasive diagnostic tools for H. pylori infection and assess their correlation with esophagogastroduodenoscopic (EGD) findings. The study utilized the Campylobacter-Like Organism (CLO) test, serum anti-HP IgG blood test, and C-13-urea breath test (UBT) to diagnose H. pylori infection. A total of 100 patients with peptic ulcer symptoms, including 45 males and 55 females, were recruited for the study. Symptomatic patients between the ages of 20–70, eligible for EGD examination, were enrolled. Each diagnostic test and any combination of two positive tests were considered the reference standard and compared against the other diagnostic methods. Additionally, the relationship between these diagnostic tests and EGD findings was evaluated. Among the participants, 74.0% were diagnosed with peptic ulcer disease through EGD. The UBT demonstrated the highest Youden's index, ranging from 58 to 100%, against all the non-invasive tests. The IgG blood test displayed the highest sensitivity at 100%, with a specificity of 60–70%. On the other hand, the CLO test exhibited the highest specificity at 100% and a sensitivity of 50–85%. Furthermore, only the CLO test showed a significant association with esophageal ulcers (p-value = 0.01). The IgG blood test holds promise as a primary screening tool due to its exceptional sensitivity. While the UBT is relatively expensive, its non-invasive nature and high sensitivity and specificity make it a potential standalone diagnostic test for H. pylori infection. Moreover, the noteworthy negative correlation between the CLO test and esophageal ulcers provides evidence of the differing effects of H. pylori infection on antral-predominant and corpus-predominant gastritis.
Hybrid surgery can improve neurocognitive function in patients with internal carotid artery occlusion
Authors: Tang Yudi , Yang Yunna , Feng Junqiang , Geng Yibo , Wang Yang , Wang Rong , Zhang Dong , Zhao Jizong 
Published: December 2023

AbstractInternal carotid artery occlusion (ICAO) is a relatively uncommon but important cause of transient ischaemic attack and cerebral infarction. Hybrid surgery (HS) improves cerebral perfusion, but its impact on neurocognitive function has been controversial. Patients with symptomatic chronic ICAO treated by hybrid surgery or medical treatment from 2016 to 2019 were included. We recorded and analysed the clinical characteristics, angiographic data, outcomes and cognitive status. Functional assessments, including the National Institutes of Health Stroke Scale (NIHSS), the Barthel Index, and a battery of neuropsychological tests, including the Mini-Mental State Examination (MMSE), Alzheimer Disease Assessment Scale–Cognitive Subtest (ADAS-cog), verbal fluency, and Colour Trail test Parts 1 and 2, were administered. Significant improvements in the ADAS (before, 7.5 ± 6.2 versus after, 5.2 ± 5.7; P = 0.022), MMSE (before, 25.5 ± 2.8 versus after, 28.1 ± 2.3; P = 0.013), and Colour Trail test Part 1 (before, 118.3 ± 26.5 versus after, 96.2 ± 23.1; P = 0.016) were observed six months after HS. Moreover, the abovementioned postprocedure scales were ameliorated in the HS group. This study found that in patients with multiple symptomatic ICAO and objective ipsilateral ischaemia, successful HS leads to improvement in the scores of three cognitive tests.
Impairment of vocational activities and financial problems are frequent among German blood cancer survivors
Authors: Baum Julia , Lax Hildegard , Lehmann Nils , Merkel-Jens Anja , Beelen Dietrich W. , Jöckel Karl-Heinz , Dührsen Ulrich 
Published: December 2023

AbstractLittle is known about changes in the personal living conditions of long-term blood cancer survivors in Germany. To gather information about social relationships, work life, overall well-being, and religion, we performed a questionnaire-based retrospective study on 1551 survivors who had been on follow-up for ≥ 3 years (median, 9 years). Most survivors reported that marital status and relationships with relatives and friends remained constant before and after blood cancer. Vocational activities were temporarily impaired for 47.5%, with a median time of 11 months to return to work. More than a third of the patients (35.6%) discontinued work permanently, with disability and retirement pension rates of 7.9% and 38.1%, respectively, at the time of the survey. Financial problems due to reduced income were reported by 26.2%, in particular after relapse or allogeneic transplantation. Patient reports addressing their quality of life showed large variations. It was best in acute leukemia survivors without a history of allogeneic transplantation and worst in patients with myeloproliferative disorders. Religion tended to become more important after blood cancer. In conclusion, vocational impairment and financial problems are frequent among German blood cancer survivors. Efforts should be made at an early stage to reestablish the patients’ ability to work.
Towards automated sleep-stage classification for adaptive deep brain stimulation targeting sleep in patients with Parkinson’s disease
Authors: Carver Katrina , Saltoun Karin , Christensen Elijah , Abosch Aviva , Zylberberg Joel , Thompson John A. 
Published: December 2023

AbstractSleep dysfunction affects over 90% of Parkinson’s disease patients. Recently, subthalamic nucleus deep brain stimulation has shown promise for alleviating sleep dysfunction. We previously showed that a single-layer neural network could classify sleep stages from local field potential recordings in Parkinson’s disease patients. However, it was unable to categorise non-rapid eye movement into its different sub-stages. Here we employ a larger hidden layer network architecture to distinguish the substages of non-rapid eye movement with reasonable accuracy, up to 88% for the lightest substage and 92% for deeper substages. Using Shapley attribution analysis on local field potential frequency bands, we show that low gamma and high beta are more important to model decisions than other frequency bands. These results suggest that the proposed neural network-based classifier can be employed for deep brain stimulation treatment in commercially available devices with lower local field potential sampling frequencies.