bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le curatif, le palliatif… quelle importance ?

L’expérience de parents ayant accompagné leur enfant dans la grande
maladie et la fin de vie
Authors: Fortin Sylvie , Lessard Sabrina , Lajeunesse Alizée 
Published: January 2024

Cadre de la recherche : Dans la grande maladie,
la prolifération des possibilités thérapeutiques retarde souvent le moment où la mort est
envisagée et où les soins palliatifs, trop souvent associés à la fin de vie et à la mort,
sont introduits dans les trajectoires des malades. Dans ce contexte, les soins palliatifs
pédiatriques tentent de jouer un rôle actif dans la relation de soins, au-delà de l’idée
de traitements pour la guérison.
Objectifs : Notre article cherche à mieux
comprendre le moment où les soins palliatifs deviennent une possibilité dans la
trajectoire de la grande maladie, et comment ils sont représentés. Nous nous intéressons à
la place que ces soins occupent dans le vécu des parents, ainsi que la manière dont
s’exprime leur expérience de la grande maladie, et plus précisément la dimension
relationnelle de la fin de vie.
Méthodologie : Nous nous appuyons sur les
témoignages de parents dont les enfants ont souffert de maladies graves et de décès. Par
le biais d’entretiens individuels semi-dirigés entre 2017 et 2019, nous avons recueilli
les histoires de 16 enfants et adolescents montréalais d’origine migrante ou non-migrante
(10 garçons et 6 filles âgés de quelques semaines à
19 ans),
atteints d’une maladie génétique ou rare, d’un cancer ou de plusieurs maladies
chroniques.
Résultats : Non seulement le type de maladie
est une composante importante dans le parcours des soins palliatifs, mais le care et le profil des familles sont également déterminants dans la
perception d’une expérience (néanmoins) positive de la fin de vie de leur enfant.
Conclusions : Les perspectives thérapeutiques
curatives/palliatives ont peu d’influence sur la satisfaction de nos participants quant
aux soins de fin de vie, tant qu’un lien de confiance thérapeutique est présent entre la
famille et l’équipe soignante. Que ce soit positif ou négatif, ce lien de confiance
influence les relations de soins pédiatriques et les trajectoires de maladies graves,
ainsi que les expériences de fin de vie vécues par les proches.
Contribution : À travers les expériences
d’enfants en fin de vie telles que partagées (principalement) par les mères, cet article
aborde les perspectives curatives et palliatives telles que choisies par les parents
d’enfants confrontés à un sombre pronostic. Au-delà des différentes philosophies qui
habitent ces approches, la qualité (et la continuité) des relations établies avec les
soignants est un facteur déterminant dans la qualité des expériences documentées par notre
étude.
L’accompagnement d’un enfant atteint de cancer :
une expérience aux multiples contextes pour les familles habitant loin des centres
spécialisés
Authors: Simard Chantale 
Published: January 2024

Cadre de la recherche : Le cancer est la maladie
potentiellement mortelle la plus fréquente chez les enfants canadiens. Il s’agit d’une
expérience familiale traumatique. Des auteurs soulignent que les familles touchées sont
plus vulnérables si elles ne disposent pas de ressources suffisantes pour favoriser leur
processus de résilience. Or, celles habitant une localité éloignée des centres
hospitaliers spécialisés en oncologie pédiatrique (CHSOP) sont confrontées à des défis
additionnels en raison de leur accès limité à des ressources et services pouvant répondre
à leurs besoins immédiats. Alors que l’expérience familiale du cancer pédiatrique est
abondamment décrite dans les écrits scientifiques, celle liée à l’éloignement des CHSOP
demeure peu explorée. L’approche de soins fondée sur les forces de la personne et la
famille de Gottlieb et la théorie du renforcement de la résilience familiale de Walsh
(2012 ; 2016b) ont guidé cette étude. Cet article présente des résultats issus de la
première phase d’une plus vaste étude, conduite entre 2015 et 2021, soit ceux liés aux
différents contextes pouvant exacerber la vulnérabilité des familles.
Objectif : Explorer les facteurs liés au
processus de résilience de familles accompagnant un enfant atteint de cancer en contexte
d’éloignement (FAECCÉ).
Méthodologie : Une approche qualitative
descriptive a été adoptée à l’aide de 26 entrevues semi-structurées individuelles et de
groupe (n= 50 personnes : 39 membres de 11 familles, 11 infirmières).
Résultats : Parmi l’ensemble des résultats
obtenus lors de la plus vaste étude, deux principaux contextes d’éloignement ont été
dégagés et sont ici présentés : (1) lorsque les FAECCÉ sont dans leur localité, lors du
diagnostic de l’enfant, des retours du CHSOP et au quotidien, et (2) lorsqu’elles sont au
CHSOP, loin des personnes qui leur sont chères et de leurs repères habituels. Des
contextes aux facteurs de risque spécifiques, qui peuvent compromettre leur processus de
résilience.
Conclusions : L’éloignement est une expérience
multicontextuelle, persistante, qui touche tous les membres de la famille. Elle exige une
évaluation familiale particulière, et est favorisée par une meilleure communication et
collaboration entre les centres hospitaliers spécialisés et régionaux.
Contribution : La proposition de précieuses
pistes pour des soins plus adaptés à la réalité des FAECCÉ.
Perceived Organizational Support as Mediation of Work Engagement and Self-efficacy on Employee Performance
Authors: Nugraha Desta , Kharismasyah Alfato Yusnar 
Published: January 2024

Objective: Employee performance in the context of the government agency sector is a significant concern, considering their vital role in providing public services and achieving development goals. The understanding of how perceived organizational support (POS) functions as mediation in the context of an agency still needs to be improved. Therefore, this research aims to fill the gap in previous research and explain the role of POS as a mediator that facilitates the influence of work engagement and self-efficacy on employee performance in the agency environment.
Study Design: In this research, perceived organizational support (POS) is considered a mediating mechanism that can explain the relationship between work engagement, self-efficacy, and employee performance.
Place and Duration of Study: Water Resources Management Center of Serayu Citanduy, Indonesia, between November 2023 and January 2024.
Methodology: This research involved 105 respondents who were employees at the Serayu Citanduy Water Resources Management Center. Data was collected through questionnaires, and data analysis was carried out using SmartPLS 4.0 software.
Results: There is a significant positive effect of work engagement on employee performance (β= .228, P value= .011), self-efficacy on employee performance (β= .238, P value= .017), POS on employee performance (β= .366, P value= .001), work engagement on employee performance through POS (β= .154, P value= .016), and self-efficacy on employee performance through POS (β= .122, P value= .004).
Conclusion: Partially, work engagement, self-efficacy, and POS have a positive and significant relationship with employee performance. Employees who feel involved in work will easily be used as capital by the organization or company to increase productivity. Employee who feels confident in their abilities will find it easier to develop themselves and later perform well. In addition, this research found that POS acts as a mediator, connecting work engagement and self-efficacy with employee performance indirectly.
Studies on Fresh and Cryopreserved Seminal Attributes in Beetal Bucks Outside their Breeding Tract
Authors: Keshav . , Dutta Mitali , Rongmei Soihem Diana , Yadav Anand Kumar , Jadav Ravindra 
Published: January 2024

The objectives of the present research were to assess fresh and cryopreserved. seminal characteristics of breeding Beetal buck semen outside of its breeding tract. Semen was collected twice in a week from twelve Beetal bucks for 6 weeks. The mean value of ejaculate volume(ml), mass motility(o-5 scale), progressive motility(%), sperm viability (%), intact acrosome(%), sperm abnormality(%) and plasma membrane integrity(%) were ranged from 0.73 ± 0.08 ml to 1.17 ± 0.27 ml; 4.17+ to 4.67+, 80.83 ± 1.54 to 87.50 ± 2.14; 83.83 ± 0.95 to 90.33 ± 0.80; 87.00 ± 0.86 to 94.67 ± 0.33; 6.83 ± 0.31 to 10.33 ± 0.67 and 59.33 ± 1.52 to 66.67 ± 1.17, respectively. The mean value of post thaw sperm motility, post thaw sperm viability, post thaw acrosome integrity, post thaw sperm abnormalities and post thaw plasma membrane integrity were ranged from 52.50± 1.12 to 66.67 ± 1.67; 60.00 ± 1.24 to 69.67 ± 1.05; 66.00 ± 0.77 to 78.83 ± 2.15; 9.00 ± 0.45 to 12.83 ± 0.60 and 41.50 ± 1.18 to 53.50 ± 1.23, respectively. It was determined that, even outside of the breeding tract, the foundational characteristics of Beetal bucks are within the range defined for other Indian breeds of goat.
Mixture‐based adaptive probabilistic control
Authors: Kárný Miroslav , Böhm Josef , Guy Tatiana V. , Nedoma Petr 
Published: March 2003

AbstractQuasi‐Bayes algorithm, combined with stabilized forgetting, provides a tool for efficient recursive estimation of dynamic probabilistic mixture models. They can be interpreted either as models of closed‐loop with switching modes and controllers or as a universal approximation of a wide class of non‐linear control loops.Fully probabilistic control design extended to mixture models makes basis of a powerful class of adaptive controllers based on the receding‐horizon certainty equivalence strategy.Paper summarizes the basic elements mentioned above, classifies possible types of control problems and provides solution of the key one referred to as ‘simultaneous’ design. Results are illustrated on mixtures with components formed by normal auto‐regression models with external variable (ARX). Copyright © 2003 John Wiley & Sons, Ltd.
Rapid platelet inhibition after a single capsule of Aggrenox®: Challenging a conventional full‐dose aspirin antiplatelet advantage?
Authors: Serebruany Victor L. , Malinin Alex I. , Sane David C. 
Published: March 2003

AbstractAggrenox® is a novel combination of 25 mg of aspirin with 200 mg of sustained release dipyridamole. In a recent large trial (ESPS‐2), Aggrenox® was twice as effective for secondary stroke prevention as either aspirin or dipyridamole alone, suggesting superior platelet inhibition for combination therapy. We sought to compare the time course of platelet inhibition with Aggrenox® compared with escalating doses of non‐enteric coated aspirin. Data from 10 healthy volunteers were analyzed. Fasting subjects sequentially ingested aspirin in the following order: 325 mg, 81 mg, 25 mg, and then one pill of Aggrenox® after a 3‐week interval for aspirin washout. Platelet function was assessed at baseline, 15, 30, 60, and 120 min post‐medication with 5 μM epinephrine and 5 μM ADP using conventional aggregometry. Aspirin provided significant (P < 0.01) reduction of platelet aggregation at 15 min post 325 mg, 30 min post 81 mg, and unexpectedly within 60 min after taking 25 mg of aspirin. A single pill of Aggrenox® also inhibited platelet aggregation within 1 hr after administration. Aspirin inhibits platelets remarkably fast. Both Aggrenox® and a matching dose of aspirin (25 mg) exhibit significant antiplatelet properties within 60 min after ingestion. These findings could be relevant for the optimal balance between the reduction of vascular events via sufficient and rapid platelet inhibition and low risk of bleeding complications associated with the Aggrenox® therapy. Am. J. Hematol. 72:280–281, 2003. © 2003 Wiley‐Liss, Inc.
A novel mechanism underlying drug resistance in chronic epilepsy
Authors: Remy Stefan , Gabriel Siegrun , Urban Bernd W. , Dietrich Dirk , Lehmann Thomas N. , Elger Christian E. , Heinemann Uwe , Beck Heinz 
Published: March 2003

AbstractThe development of resistance to pharmacological treatment is common to many human diseases. In chronic epilepsy, many patients develop resistance to anticonvulsant drug treatment during the course of their disease, with the underlying mechanisms remaining unclear. We have studied cellular mechanisms underlying drug resistance in resected hippocampal tissue from patients with temporal lobe epilepsy by comparing two groups of patients, the first displaying a clinical response to the anticonvulsant carbamazepine and a second group with therapy‐resistant seizures. Using patch‐clamp recordings, we show that the mechanism of action of carbamazepine, use‐dependent block of voltage‐dependent Na+ channels, is completely lost in carbamazepine‐resistant patients. Likewise, seizure activity elicited in human hippocampal slices is insensitive to carbamazepine. In marked contrast, carbamazepine‐induced use‐dependent block of Na+ channels and blocked seizure activity in vitro in patients clinically responsive to this drug. Consistent with these results in human patients, we also show that use‐dependent block of Na+ channels by carbamazepine is absent in chronic experimental epilepsy. Taken together, these data suggest that a loss of Na+ channel drug sensitivity may constitute a novel mechanism underlying the development of drug‐resistant epilepsy. Ann Neurol 2003
[123I]‐FP‐CIT‐SPECT demonstrates dopaminergic deficit in orthostatic tremor
Authors: Katzenschlager Regina , Costa Durval , Gerschlager Willibald , O'Sullivan John , Zijlmans Jan , Gacinovic Svetoslav , Pirker Walter , Wills Adrian , Bhatia Kailash , Lees Andrew J. , Brown Peter 
Published: March 2003

AbstractThere is increasing evidence of a potential role of the dopaminergic system in orthostatic tremor (OT): Association with parkinsonism and treatment effects of L‐dopa and dopamine agonists have been reported. Eleven patients with isolated OT had single‐photon emission computed tomography (SPECT) using 123I‐FP‐CIT ([123I]‐2β‐carbomethoxy‐3β‐(‐4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane) as dopamine transporter tracer. Results were compared with 12 age‐matched normal controls and 12 patients with Parkinson's disease (PD). A marked reduction in striatal tracer binding was found in OT compared to normal controls (p < 0.001). Tracer uptake was significantly higher and more symmetrical than in PD, and caudate and putamen were equally affected. L‐dopa challenges, performed in seven patients, showed a small but non‐significant improvement on EMG and a small but significant improvement in clinical parameters on blinded video rating. Two‐month open‐label L‐dopa treatment (600 mg/day) led to a small improvement in two of five patients but no significant overall change. Olfactory function on University of Pennsylvania Smell Identification Test was normal. Our finding of a marked tracer uptake reduction on dopamine transporter SPECT supports a role of the dopaminergic system in OT. Lack of evidence of a clinically relevant therapeutic response to L‐dopa suggests that other mechanisms must also be involved in the pathogenesis. Ann Neurol 2003
Phenotype modulators in myophosphorylase deficiency
Authors: Martinuzzi Andrea , Sartori Elena , Fanin Marina , Nascimbeni Annachiara , Valente Lucia , Angelini Corrado , Siciliano Gabriele , Mongini Tiziana , Tonin Paola , Tomelleri Giuliano , Toscano Antonio , Merlini Luciano , Bindoff Laurence A. , Bertelli Stefano 
Published: March 2003

AbstractMyophosphorylase deficiency is characterized by exercise intolerance, muscle cramps, and recurrent myoglobinuria. Some patients are severely affected, whereas others are minimally affected or asymptomatic. The molecular basis of the disease has been elucidated but does not provide an explanation for the clinical variability. In a large cohort of patients with myophosphorylase deficiency, we tested the hypothesis that polymorphic variants in either myoadenylate deaminase (MADA) or angiotensin‐converting enzyme (ACE) could act as modulators of phenotype expression. Forty‐seven patients were evaluated. Clinical severity was assessed according to a severity scale of four grades. MADA activity was studied by histochemical and biochemical analysis of muscle, and the Q12X mutation in the adenine monophosphate deaminase 1 gene (AMPD1) and the insertion/deletion polymorphism in the ACE gene were assessed genetically. A complete MADA defect together with the Q12X mutation was detected in one severely affected patient. Eleven patients were heterozygous for the Q12X mutation. There was no association between clinical grading and MADA status. In contrast, we found a highly significant (p < 0.01) association between ACE genotype and clinical severity, with strong correlation between severe phenotype and number of D alleles. We show that ACE insertion/deletion polymorphism may play a significant role as phenotype modulator in McArdle's disease. Ann Neurol 2003
Efficient three‐drug cocktail for disease induced by mutant superoxide dismutase
Authors: Kriz Jasna , Gowing Geneviève , Julien Jean‐Pierre 
Published: March 2003

AbstractThere is currently no effective pharmacological treatment for amyotrophic lateral sclerosis (ALS). Because evidence suggests that multiple pathways may contribute to ALS pathogenesis, we tested in a mouse model of ALS (SOD1G37R mice) a combination approach consisting of three drugs for distinct targets in the complex pathway to neuronal death: minocycline, an antimicrobial agent that inhibits microglial activation, riluzole, a glutamate antagonist, and nimodipine, a voltage‐gated calcium channel blocker. The efficacy of this three‐drug cocktail was remarkable when administered in the diet from late presymptomatic stage (8–9 months). It delayed the onset of disease, slowed the loss of muscle strength, and increased the average longevity of SOD1G37R mice by 6 weeks. The protective effect of the treatment was corroborated by the reduced immunodetection signals for markers of gliosis and neurodegeneration in the spinal cord of SOD1G37R mice. These results indicate that such three‐drug combination may represent an effective strategy for ALS treatment. Ann Neurol 2003
Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia
Authors: Albin Roger L. , Cross Donna , Cornblath Wayne T. , Wald John A. , Wernette Kristine , Frey Kirk A. , Minoshima Satoshi 
Published: March 2003

AbstractStriatal dysfunction is thought to underlie many dystonias. We used [123I]iodobenzovesamicol single‐photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [131I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia. Ann Neurol 2003;53:528–532
A randomized sequential trial of creatine in amyotrophic lateral sclerosis
Authors: Jan Groeneveld Geert , Veldink Jan H. , van der Tweel Ingeborg , Kalmijn Sandra , Beijer Cornelis , de Visser Marianne , Wokke John H. J. , Franssen Hessel , Berg Leonard H. van den 
Published: March 2003

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal disease with no cure. In a transgenic mouse model of ALS, creatine monohydrate showed a promising increase in survival. We performed a double‐blind, placebo‐controlled, sequential clinical trial to assess the effect of creatine monohydrate on survival and disease progression in patients with ALS. Between June 2000 and December 2001, 175 patients with probable, probable‐laboratory supported, or definite ALS were randomly assigned to receive either creatine monohydrate or placebo 10gm daily. A sequential trial design was used with death, persistent assisted ventilation, or tracheostomy as primary end points. Secondary outcome measurements were rate of decline of isometric arm muscle strength, forced vital capacity, functional status, and quality of life. The trial was stopped when the null hypothesis of indifference was accepted. Creatine did not affect survival (cumulative survival probability of 0.70 in the creatine group vs 0.68 in the placebo group at 12 months, and 0.52 in the creatine group vs 0.47 in the placebo group at 16 months), or the rate of decline of functional measurements. Creatine intake did not cause important adverse reactions. This placebo‐controlled trial did not find evidence of a beneficial effect of creatine monohydrate on survival or disease progression in patients with ALS. Ann Neurol 2003;53:437–445
Maternal neuronal antibodies associated with autism and a language disorder
Authors: Dalton Paola , Deacon Robert , Blamire Andy , Pike Michael , McKinlay Ian , Stein John , Styles Peter , Vincent Angela 
Published: March 2003

AbstractNeurodevelopmental disorders could be caused by maternal antibodies or other serum factors. We detected serum antibodies binding to rodent Purkinje cells and other neurons in a mother of three children: the first normal, the second with autism, and the third with a severe specific language disorder. We injected the serum (0.5–1.0ml/day) into pregnant mice during gestation and found altered exploration and motor coordination and changes in cerebellar magnetic resonance spectroscopy in the mouse offspring, comparing with offspring of mice injected with sera from mothers of healthy children. This evidence supports a role for maternal antibodies in some forms of neurodevelopmental disorder. Ann Neurol 2003;53:533–537
Cyclohex‐1‐ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase
Authors: Baston Eckhard , Salem Ola I. A. , Hartmann Rolf W. 
Published: March 2003

AbstractIn search of novel nonsteroidal mimics of steroidal inhibitors of 5α reductase, 4‐(2‐phenylethyl)cyclohex‐1‐ene carboxylic acids 1—5 were synthesized with different substituents in para position of the phenyl ring (1: N, N‐diisopropylcarbamoyl, 2: phenyl, 3: phenoxy, 4: benzoyl, and 5: benzyl). The principal synthetic approach for the desired compounds consisted of a Wittig olefination between 1, 4‐dioxaspiro [4.5]‐decane‐8‐carbaldehyde (4g and the appropriate phosphonium salts. The compounds were tested for inhibition of human 5α reductase isozymes 1 and 2 using DU 145 cells and preparations from prostatic tissue, respectively. They turned out to be good inhibitors of the prostatic isozyme 2 with compound 1 being the most potent one (IC50 = 760 nM). Isozyme 1 was only slightly inhibited. It is concluded that the novel structures are appropriate for being further optimized, aiming at the development of a novel drug for the treatment of benign prostatic hyperplasia.
Unique reactivity of α,β‐unsaturated carboxylic acid imidazolides: Catalytic asymmetric synthesis of α,β‐epoxy esters and α,β‐epoxy carboxylic acid derivatives
Authors: Nemoto Tetsuhiro , Tosaki Shin‐Ya , Ohshima Takashi , Shibasaki Masakatsu 
Published: March 2003

AbstractCatalytic asymmetric synthesis of α,β‐epoxy esters and α,β‐epoxy carboxylic acid derivatives is described. Catalytic asymmetric epoxidation of α,β‐unsaturated carboxylic acid imidazolides using La–BINOL–Ph3As=O complex gave the corresponding α,β‐epoxy peroxy tert‐butyl esters, which were directly converted to the α,β‐epoxy methyl esters by adding methanol to the reaction. This catalytic system had broad generality for epoxidation of various substrates. With the use of 5–10 mol% of the catalyst, both β‐aryl and β‐alkyl‐substituted‐α,β‐epoxy methyl esters were obtained in up to 91% yield and in up to 93% enantiomeric excess. In addition, efficient transformations of α,β‐epoxy peroxy tert‐butyl esters into the α,β‐epoxy amides, α,β‐epoxy aldehydes, and γ,δ‐epoxy β‐keto esters are also reported. Chirality 15:306–311, 2003. © 2003 Wiley‐Liss, Inc.