bluuebunny/crossref_metadata_2025_split huggingface dataset:
The changing landscape of thyroid eye disease: current clinical advances and future outlook
Authors: Moledina Malik , Damato Erika M. , Lee Vickie 
Published: February 2024

Abstract
Aims
This review aims to provide an overview of the current understanding of TED and its pathophysiology. To describe the evidence base for current consensus treatment recommendations and newer biological therapies available as well as to present future therapeutic research.

Methods
We reviewed and assessed the peer-reviewed literature placing particular emphasis on recent studies evaluating the pathophysiology of TED, landmark trials forming the basis of current management and recent clinical trials informing future therapeutics. Searched were made in MEDLINE Ovid, Embase Ovid, US National Institutes of Health Ongoing Trials Register and EU Clinical Trials Register. Keywords included: “Thyroid Eye Disease”, “Graves Orbitopathy”, “Thyroid Orbitopathy” and “Graves’ Ophthalmopathy”.

Results and conclusions
The pathophysiology of TED involves a complex array of cellular and humoral based autoimmune dysfunction. Previous therapies have been broad-based acting as a blunt instrument on this mechanism with varying efficacy but often accompanied with a significant side effect profile. The recent development of targeted therapy, spearheaded by Teprotumumab has led to an array of treatments focusing on specific components of the molecular pathway optimising their impact whilst possibly minimising their side effect profile. Future challenges involve identifying the most effective target for each patient rather than any single agent being a panacea. Long-term safety profiles will require clarification as unintended immunological consequence downstream may become manifest as seen in other diseases. Finally, future novel therapeutics will entail significant expenditure and may lead to a divergence of available treatment modalities between healthcare systems due to funding disparities.
A SPLICS reporter reveals $${{{{{\boldsymbol{\alpha }}}}}}$$-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation
Authors: Giamogante Flavia , Barazzuol Lucia , Maiorca Francesca , Poggio Elena , Esposito Alessandra , Masato Anna , Napolitano Gennaro , Vagnoni Alessio , Calì Tito , Brini Marisa 
Published: February 2024

AbstractMitochondrial and lysosomal activities are crucial to maintain cellular homeostasis: optimal coordination is achieved at their membrane contact sites where distinct protein machineries regulate organelle network dynamics, ions and metabolites exchange. Here we describe a genetically encoded SPLICS reporter for short- and long- juxtapositions between mitochondria and lysosomes. We report the existence of narrow and wide lysosome-mitochondria contacts differently modulated by mitophagy, autophagy and genetic manipulation of tethering factors. The overexpression of α-synuclein (α-syn) reduces the apposition of mitochondria/lysosomes membranes and affects their privileged Ca2+transfer, impinging on TFEB nuclear translocation. We observe enhanced TFEB nuclear translocation in α-syn-overexpressing cells. We propose that α-syn, by interfering with mitochondria/lysosomes tethering impacts on local Ca2+regulated pathways, among which TFEB mediated signaling, and in turn mitochondrial and lysosomal function. Defects in mitochondria and lysosome represent a common hallmark of neurodegenerative diseases: targeting their communication could open therapeutic avenues.
Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases
Authors: Bazzani Davide , Heidrich Vitor , Manghi Paolo , Blanco-Miguez Aitor , Asnicar Francesco , Armanini Federica , Cavaliere Sara , Bertelle Alberto , Dell’Acqua Federico , Dellasega Ester , Waldner Romina , Vicentini Daniela , Bolzan Mattia , Tomasi Cristiano , Segata Nicola , Pasolli Edoardo , Ghensi Paolo 
Published: February 2024

AbstractWe performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling methods, we identified the most discriminative species between healthy and diseased subjects at baseline, evaluated their change over time, and provided evidence that clinical treatment had a positive effect on plaque microbiome composition in patients affected by mucositis and peri-implantitis.
Transomics2cytoscape: an automated software for interpretable 2.5-dimensional visualization of trans-omic networks
Authors: Nishida Kozo , Maruyama Junichi , Kaizu Kazunari , Takahashi Koichi , Yugi Katsuyuki 
Published: February 2024

AbstractBiochemical network visualization is one of the essential technologies for mechanistic interpretation of omics data. In particular, recent advances in multi-omics measurement and analysis require the development of visualization methods that encompass multiple omics data. Visualization in 2.5 dimension (2.5D visualization), which is an isometric view of stacked X-Y planes, is a convenient way to interpret multi-omics/trans-omics data in the context of the conventional layouts of biochemical networks drawn on each of the stacked omics layers. However, 2.5D visualization of trans-omics networks is a state-of-the-art method that primarily relies on time-consuming human efforts involving manual drawing. Here, we present an R Bioconductor package ‘transomics2cytoscape’ for automated visualization of 2.5D trans-omics networks. We confirmed that transomics2cytoscape could be used for rapid visualization of trans-omics networks presented in published papers within a few minutes. Transomics2cytoscape allows for frequent update/redrawing of trans-omics networks in line with the progress in multi-omics/trans-omics data analysis, thereby enabling network-based interpretation of multi-omics data at each research step. The transomics2cytoscape source code is available at https://github.com/ecell/transomics2cytoscape.
Spatially reconfigurable antiferromagnetic states in topologically rich free-standing nanomembranes
Authors: Jani Hariom , Harrison Jack , Hooda Sonu , Prakash Saurav , Nandi Proloy , Hu Junxiong , Zeng Zhiyang , Lin Jheng-Cyuan , Godfrey Charles , Omar Ganesh ji , Butcher Tim A. , Raabe Jörg , Finizio Simone , Thean Aaron Voon-Yew , Ariando A. , Radaelli Paolo G. 
Published: February 2024

AbstractAntiferromagnets hosting real-space topological textures are promising platforms to model fundamental ultrafast phenomena and explore spintronics. However, they have only been epitaxially fabricated on specific symmetry-matched substrates, thereby preserving their intrinsic magneto-crystalline order. This curtails their integration with dissimilar supports, restricting the scope of fundamental and applied investigations. Here we circumvent this limitation by designing detachable crystalline antiferromagnetic nanomembranes of α-Fe2O3. First, we show—via transmission-based antiferromagnetic vector mapping—that flat nanomembranes host a spin-reorientation transition and rich topological phenomenology. Second, we exploit their extreme flexibility to demonstrate the reconfiguration of antiferromagnetic states across three-dimensional membrane folds resulting from flexure-induced strains. Finally, we combine these developments using a controlled manipulator to realize the strain-driven non-thermal generation of topological textures at room temperature. The integration of such free-standing antiferromagnetic layers with flat/curved nanostructures could enable spin texture designs via magnetoelastic/geometric effects in the quasi-static and dynamical regimes, opening new explorations into curvilinear antiferromagnetism and unconventional computing.
Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells
Authors: Kamen Yasmine , Evans Kimberley Anne , Sitnikov Sergey , Spitzer Sonia Olivia , de Faria Omar , Yucel Mert , Káradóttir Ragnhildur Thóra 
Published: February 2024

AbstractIn the central nervous system, oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, allowing for ongoing myelination and myelin repair. With age, differentiation efficacy decreases and myelin repair fails; therefore, recent therapeutic efforts have focused on enhancing differentiation. Many cues are thought to regulate OPC differentiation, including neuronal activity, which OPCs can sense and respond to via their voltage-gated ion channels and glutamate receptors. However, OPCs’ density of voltage-gated ion channels and glutamate receptors differs with age and brain region, and correlates with their proliferation and differentiation potential, suggesting that OPCs exist in different functional cell states, and that age-associated states might underlie remyelination failure. Here, we use whole-cell patch-clamp to investigate whether clemastine and metformin, two pro-remyelination compounds, alter OPC membrane properties and promote a specific OPC state. We find that clemastine and metformin extend the window of NMDAR surface expression, promoting an NMDAR-rich OPC state. Our findings highlight a possible mechanism for the pro-remyelinating action of clemastine and metformin, and suggest that OPC states can be modulated as a strategy to promote myelin repair.
Green chemistry routed sugar press mud for (2D) ZnO nanostructure fabrication, mineral fortification, and climate-resilient wheat crop productivity
Authors: Verma Lahur Mani , Kumar Ajay , Kumar Ashwani , Singh Garima , Singh Umesh , Chaudhary Shivani , Kumar Sachin , Sanwaria Anita Raj , Ingole Pravin P. , Sharma Satyawati 
Published: February 2024

AbstractNanotechnology appears to be a promising tool to redefine crop nutrition in the coming decades. However, the crucial interactions of nanomaterials with abiotic components of the environment like soil organic matter (SOM) and carbon‒sequestration may hold the key to sustainable crop nutrition, fortification, and climate change. Here, we investigated the use of sugar press mud (PM) mediated ZnO nanosynthesis for soil amendment and nutrient mobilisation under moderately alkaline conditions. The positively charged (+ 7.61 mv) ZnO sheet-like nanoparticles (~ 17 nm) from zinc sulphate at the optimum dose of (75 mg/kg blended with PM (1.4% w/w) were used in reinforcing the soil matrix for wheat growth. The results demonstrated improved agronomic parameters with (~ 24%) and (~ 19%) relative increases in yield and plant Zn content. Also, the soil solution phase interactions of the ZnO nanoparticles with the PM-induced soil colloidal carbon (− 27.9 mv and diameter 0.4864 μm) along with its other components have influenced the soil nutrient dynamics and mineral ecology at large. Interestingly, one such interaction seems to have reversed the known Zn-P interaction from negative to positive. Thus, the study offers a fresh insight into the possible correlations between nutrient interactions and soil carbon sequestration for climate-resilient crop productivity.
Geothermal power generation and positive impact in the greater bay area: a case study of Huizhou City, Guangdong Province
Authors: Cai Wenquan , Li Jianying , Xiao Chuantao 
Published: February 2024

AbstractGeothermal resources, as abundant renewable and clean natural resources on Earth, have been utilized for geothermal power generation in 29 countries. Guangdong Province, as one of the most developed, economically vibrant, and attractive investment regions in China, has experienced rapid economic growth. However, further development is constrained by resource limitations and severe ecological environmental pressures. The issue of energy consumption and economic growth imbalance needs to be urgently addressed. Geothermal energy, as a clean and stable form of energy, can reduce reliance on fossil fuels, decrease dependence on imported energy, and enhance national energy security. In this study, geological survey, geophysical survey, geochemical survey, remote sensing detection and drilling were carried out in the Shiba–Huangshadong area of Huizhou, and by analyzing the data on geothermal energy reserves in the study area, the available geothermal energy and its potentials in the study area were identified and its impact on the current energy consumption in Huizhou City was assessed, to validate the feasibility of the detailed application of the geothermal energy in the Greater Bay Area, which will enable the energy structure of Huizhou City optimize the energy structure.
GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation
Authors: Mendonça-dos-Santos Marcelo , Gonçalves Thaís Cristina Teixeira , Falconi-Sobrinho Luiz Luciano , dos Anjos-Garcia Tayllon , Matias Ivair , de Oliveira Rithiele Cristina , dos Santos Sampaio Maria de Fátima , dos Santos Cardoso Fabrízio , dos Santos Wagner Ferreira , Machado Helio Rubens , Coimbra Norberto Cysne 
Published: February 2024

AbstractWe investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS GABAergic interneurons and noradrenergic pathways from the locus coeruleus (LC) in these phenomena. The NTS-lateral nucleus reticularis paragigantocellularis (lPGi)-LC pathway was studied by evaluating neural tract tracer deposits in the lPGi. NMDA and GABAergic receptors agonists and antagonists were microinjected into the NTS, followed by pharmacologically induced seizures. The effects of LC neurotoxic lesions caused by DSP-4, followed by NTS-NMDA receptor activation, on both tonic‒clonic seizures and postictal antinociception were also investigated. The NTS is connected to lPGi neurons that send outputs to the LC. Glutamatergic vesicles were found on dendrites and perikarya of GABAergic interneurons in the NTS. Both tonic‒clonic seizures and postictal antinociception are partially dependent on glutamatergic-mediated neurotransmission in the NTS of seizing rats in addition to the integrity of the noradrenergic system since NMDA receptor blockade in the NTS and intrathecal administration of DSP-4 decrease the postictal antinociception. The GABAA receptor activation in the NTS decreases both seizure severity and postictal antinociception. These findings suggest that glutamatergic inputs to NTS-GABAergic interneurons, in addition to ascending and descending noradrenergic pathways from the LC, are critical for the control of both seizures and postictal antinociception.
Synchronous recording of magnetocardiographic and electrocardiographic signals
Authors: Pȩczalski Kazimierz , Sobiech Judyta , Buchner Teodor , Kornack Thomas , Foley Elizabeth , Janczak Daniel , Jakubowska Małgorzata , Newby David , Ford Nancy , Zajdel Maryla 
Published: February 2024

AbstractWe present a system for simultaneous recording of the electrocardiogram and the magnetocardiogram. The measurement system contained of printed carbon electrodes and SERF magnetometer. The use of this system confirms that the position of the end of the magnetic T wave extends further than the electric T wave, which is an important indicator for the diagnosis of cardiological patients and for drug arrhythmogenicity. We analyze this phenomenon in depth, and demonstrate, that it originates from the fundamental difference between electric and magnetic measurements. The measured value is always bipolar since the electric measurements require two electrodes. We demonstrate how the dual electric and magnetic measuring system adds a new information to the commonly used electrocardiographic diagnosis. The ECG should be interpreted as the spatial asymmetry of the electric cardiac potential, and not as the potential itself. The results seem to prove, that the relation between the magnetic and the electric imaging of neural activities may be broadly applied for the benefit of medical diagnosis in cardiology and many other fields, where the neural activity is measured. This is a pilot study which requires further confirmation at the clinical level.
Numerical study of the laser isotope separation of optically pumped 102Pd
Authors: Suryanarayana M. V. , Sankari M. 
Published: February 2024

AbstractThe feasibility of laser isotope separation of 102Pd through pulsed laser optical pumping followed by isotope selective photoionization has been studied through density matrix formalism. The effect of various parameters such as bandwidth of the excitation lasers, intensity of the lasers and Doppler broadening of the atomic ensemble on the efficiency of optical pumping and isotope selective photoionization have been evaluated. The optimum number density in the laser-atom interaction region has been derived from the studies of the effect of charge exchange collisions on the degree of enrichment. It has been shown that it is possible to enrich 102Pd up to ~ 23.7% at a production rate of 1.1 mg /h. The achievable degree of enrichment through this photoionization scheme is higher than the previously reported laser isotope separation process. The radionuclidic purity of the irradiated enriched mixture has been found to be suitable for medical applications.
Understanding how personality traits, experiences, and attitudes shape negative bias toward AI-generated artworks
Authors: Grassini Simone , Koivisto Mika 
Published: February 2024

AbstractThe study primarily aimed to understand whether individual factors could predict how people perceive and evaluate artworks that are perceived to be produced by AI. Additionally, the study attempted to investigate and confirm the existence of a negative bias toward AI-generated artworks and to reveal possible individual factors predicting such negative bias. A total of 201 participants completed a survey, rating images on liking, perceived positive emotion, and believed human or AI origin. The findings of the study showed that some individual characteristics as creative personal identity and openness to experience personality influence how people perceive the presented artworks in function of their believed source. Participants were unable to consistently distinguish between human and AI-created images. Furthermore, despite generally preferring the AI-generated artworks over human-made ones, the participants displayed a negative bias against AI-generated artworks when subjective perception of source attribution was considered, thus rating as less preferable the artworks perceived more as AI-generated, independently on their true source. Our findings hold potential value for comprehending the acceptability of products generated by AI technology.
Ultrasonic and conversion-based inline fouling measurements for continuous emulsion copolymerisation of vinyl acetate in a tubular reactor
Authors: Rust Sören , Osenberg Marco , Musch Thomas , Pauer Werner 
Published: February 2024

AbstractOne of the serious challenges for the implementation of continuous emulsion polymerisation is their significant fouling. The elucidation of time-dependent fouling processes and the development of inline analysis methods for fouling mass quantification are crucial to making progress in this area. Inline-sensor concepts based on ultrasonic measurements as well as residence time and conversion analysis were investigated regarding their suitability for the detection of time-dependent fouling formation and compared with gravimetrical results in order to validate their precision. Both a set-up using a turnover analysis for determination of losses in reaction volume by fouling and an ultrasound-based measurement system detecting deposit-caused changes by evaluating the average sound velocity could be used as suitable sensor concepts. The accuracies of both sensors are below 10% deviation to fouling references.
Combining independent component analysis and source localization for improving spatial sampling of stereoelectroencephalography in epilepsy
Authors: Medina Villalon Samuel , Makhalova Julia , López-Madrona Victor J. , Garnier Elodie , Badier Jean-Michel , Bartolomei Fabrice , Bénar Christian G. 
Published: February 2024

AbstractStereoelectroencephalography is a powerful intracerebral EEG recording method for the presurgical evaluation of epilepsy. It consists in implanting depth electrodes in the patient’s brain to record electrical activity and map the epileptogenic zone, which should be resected to render the patient seizure-free. Stereoelectroencephalography has high spatial accuracy and signal-to-noise ratio but remains limited in the coverage of the explored brain regions. Thus, the implantation might provide a suboptimal sampling of epileptogenic regions. We investigate the potential of improving a suboptimal stereoelectroencephalography recording by performing source localization on stereoelectroencephalography signals. We propose combining independent component analysis, connectivity measures to identify components of interest, and distributed source modelling. This approach was tested on two patients with two implantations each, the first failing to characterize the epileptogenic zone and the second giving a better diagnosis. We demonstrate that ictal and interictal source localization performed on the first stereoelectroencephalography recordings matches the findings of the second stereo-EEG exploration. Our findings suggest that independent component analysis followed by source localization on the topographies of interest is a promising method for retrieving the epileptogenic zone in case of suboptimal implantation.
An epidemiological study on early orthodontic treatment need among eastern Saudi Arabian children in the mixed dentition stage
Authors: Madiraju Guna Shekhar , Almugla Yousef Majed , Mohan Rohini , Alnasser Basil Mohammed 
Published: February 2024

AbstractEstimation of early orthodontic treatment need among children is essential for planning orthodontic interventions in the mixed dentition stages thereby reducing the burden in a publicly funded healthcare system. The present study aimed to assess the early orthodontic treatment need among children with mixed dentition in the Eastern Saudi Arabia. A descriptive cross-sectional study was conducted among Saudi children visiting the outpatient clinics in a University dental setting, and data were collected based on Index for preventive and interceptive orthodontic need (IPION). Descriptive statistics, chi-square test and Fisher’s exact test were used for data analysis with statistical significance set at p < 0.05. The category of ‘no treatment need’ accounted for 11.3% while ‘moderate treatment need’ and ‘definite treatment need’ categories accounted for 29.3% and 59.4% respectively. There was no statistical difference between males and females in the distribution of the three categories of treatment need (p = 0.513). This study demonstrated a very high need for early orthodontic treatment among Saudi children in the mixed dentition stage. Emphasis should be placed on increased awareness and benefits of seeking early orthodontic treatment involving preventive and interceptive procedures in the mixed dentition.