bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refuser de travailler pour les entreprises polluantes
Authors: Delozière Gauthier , Le Lann Yann , Solnon Anaëlle , Touzet Hugo 
Published: January 2024

En mars 2018, un groupe d’étudiant·es de grandes écoles lance un « Manifeste étudiant pour un réveil écologique » qui réunit plus de 30 000 signataires issu·es d’établissements particulièrement sélectifs de l’enseignement supérieur ainsi que de filières moins prestigieuses. En parallèle, le groupe se propose d’évaluer la responsabilité environnementale des grandes entreprises pour guider les signataires dans le choix de leur futur·e employeur·se. Au-delà du succès de la pétition, nous cherchons à analyser, dans cet article, les difficultés à mettre en œuvre, concrètement, le refus de travailler pour les entreprises polluantes. La volonté de sélectionner écologiquement son employeur·se se confronte, notamment dans les écoles de commerce, à des modes de valorisation du travail en contradiction avec une approche éthique du travail. De plus, les signataires les plus impliqué·es dans la cause de l’écologie préfèrent se détourner de l’emploi dans les grands groupes et privilégier les secteurs non marchands.
L’héritage vivant de Tullia Zevi et de Liliana Segre : résistance, identité, engagement et mémoire
Authors: Comes Annalisa 
Published: January 2024

Qu’est-ce qui lie Tullia Zevi et Liliana Segre si différentes par leur origine, leur vécu, leurs expériences au-delà de leur engagement civil et politique contre le racisme, l’antisémitisme, le langage de la haine, au-delà de leur activité de témoignage de la mémoire de la Shoah ? Leur dévouement et l’engagement assumé sont assurément similaires. Avoir pris – et prendre – la parole publiquement dans des moments difficiles de notre époque, en défense de la démocratie et des valeurs les plus profondes qu’elle incarne : la liberté, la paix, la reconnaissance des droits. Toutes deux paraissent croire dans la possibilité de transmettre ces valeurs, dans la nécessité de cultiver le sentiment de responsabilité individuelle. Toutes deux mettent leur espoir dans l’avenir des nouvelles générations. Les traits qui révèlent leur proximité sont évidents, bien sûr. Pourtant, je suis convaincue que le vrai point commun entre Tullia Zevi et Liliana Segre réside avant tout dans leur aptitude au dialogue, dans le fait d’avoir privilégié la relation.
Nimrod contre Ahmed : cananéisme et réalisme social dans le champ artistique israélien
Authors: Berman Zivi , Shabat Gadi 
Published: January 2024

Deux approches artistiques et idéologiques ont posé un défi et présenté une alternative à l’establishment politique et artistique en Israël dans les dix premières années de son existence : le courant cananéen et le réalisme social. Dans le présent article, nous examinerons ces deux courants sous l’aspect de l’alternative qu’ils ont présentée au courant dominant au sein de l’art israélien. L’article étudiera les points communs et les différences entre ces mouvements artistiques, ainsi que leur influence sur le champ de l’art israélien dans les premières années après la création de l’État. Nous nous fonderons sur l’examen de plusieurs aspects et niveaux de référence : le rapport au lieu, l’intentionnalité (l’orientation politique), le rapport au temps et à l’histoire, la canonisation et l’identité. Ces deux courants, largement opposés, n’ont pas fait le poids devant l’establishment artistique et ont été relégués aux marges du champ artistique et politique en Israël.
Ce que les séries télévisées font aux études shakespeariennes
Authors: Hatchuel Sarah 
Published: January 2024

Cet article explore la manière dont les séries télévisées ont affecté l’étude de Shakespeare, ses mises en scène au théâtre et ses adaptations, appropriations et citations à l’écran. L’existence même des séries a agi non seulement sur la manière de percevoir les pièces historiques, les pièces romaines et les romances tardives (ainsi que leurs mises en scène), mais aussi sur la mise en évidence de liens structurels et ontologiques entre production shakespearienne et production sérielle.
B-1a Cells, but Not Marginal Zone B Cells, Are Implicated in the Accumulation of Autoreactive Plasma Cells in Lyn−/− Mice
Authors: Ottens Kristina , Schneider Jalyn , Satterthwaite Anne B 
Published: January 2024

Abstract
Mice deficient in Lyn, a tyrosine kinase that limits B cell activation, develop a lupus-like autoimmune disease characterized by the accumulation of splenic plasma cells and the production of autoantibodies. Lyn−/− mice have reduced numbers of marginal zone (MZ) B cells, a B cell subset that is enriched in autoreactivity and prone to plasma cell differentiation. We hypothesized that this is due to unchecked terminal differentiation of this potentially pathogenic B cell subpopulation. However, impairing MZ B cell development in Lyn−/− mice did not reduce plasma cell accumulation or autoantibodies, and preventing plasma cell differentiation did not restore MZ B cell numbers. Instead, Lyn−/− mice accumulated B-1a cells when plasma cell differentiation was impaired. Similar to MZ B cells, B-1a cells tend to be polyreactive or weakly autoreactive and are primed for terminal differentiation. Our results implicate B-1a cells, but not MZ B cells, as contributors to the autoreactive plasma cell pool in Lyn−/− mice.
Triggered Pemphigus with Koebner Phenomenon: A Coincidence?
Authors: Prachi Bhandare , Fernandes Elreema , Thara G S Nayana , Rakhi Ghodge 
Published: January 2024

Abstract
Pemphigus includes a group of autoimmune bullous diseases of skin and/or mucous membranes characterized by intraepidermal acantholytic blisters. The onset and course of pemphigus vulgaris (PV) depend on a variable interaction between predisposing and inducing/triggering factors. Genetic predisposition has an important role and is alone not sufficient to initiate the autoimmune mechanism. The interference of inducing or triggering environmental factors seems to be crucial to set out the disease. Triggering of PV by physical agents, contact allergens, dietary factors, and emotional stress are rare, but well-documented events. The Koebner phenomenon (KP), which is described as the appearance of typical skin lesions of a certain dermatosis in uninvolved skin as a result of different kinds of trauma, is rarely documented in pemphigus. We would like to report this case due to the unusual coexistence of thermal burns triggering pemphigus and KP occurring in the same patient.
Assessment of Clinical VIDA Score, Lesional and Perilesional Dermoscopy to Evaluate Stability of the Disease in Vitiligo
Authors: Ramawanshi Smrutirama Maloji , Chandela Manisha , Manjegowda Divya , Kumar Smriti , Potdar Swaraj 
Published: January 2024

Abstract

Introduction:
Vitiligo is a complex dermatosis with an uncertain etiology, variable clinical presentations, an unpredictable course and prognosis, and difficult to treat. Surgical intervention is recommended for patients with a stable, nonprogressive vitiligo. Dermoscopy can detect the subtle changes in the pigmentary pattern and aid in the diagnosis of evolving lesions. This study was undertaken to measure the stability of the disease by classifying the patients as clinically stable and active and observing dermatological parameters.

Objective:
The aim of the study is to evaluate assess the correlation between the clinical and dermoscopic features in stable and active cases of vitiligo.

Materials and Methods:
Forty patients of vitiligo. Clinical VIDA score and six lesional and perilesional dermoscopic parameters were analyzed. Statistical analysis was done to determine their correlation.

Results:
Altered pigment network (91.6%) was the most observed dermoscopic feature followed by perifollicular depigmentation (66.7%) in clinically unstable patients and altered pigment network (87.5%) followed by leucotrichia (68.8%) was seen in clinically stable patients. However, vascularity and Koebner’s phenomena failed to produce the same.

Conclusion:
Lesional and perilesional dermoscopic examination together for the above four parameters (pigmentary network, perifollicular changes, perilesional hypopigmentary macules, and leucotrichia) will produce reliable diagnostic approach for differentiating patients as clinically stable or unstable along with clinical VIDA score.
Patch Test in Chronic Urticaria as a Diagnostic Investigative Tool – A Study in a Tertiary Care Center
Authors: Dyamannavar Shwetha F , Surendran K A K , Sori Tukaram , Dyavannanavar Veeresh 
Published: January 2024

Abstract

Background:
Chronic urticaria (CU) is associated with diverse clinical presentations and varied etiology. Contact allergy plays a critical role in the etiopathogenesis of CU; thus, a patch test can be helpful in identifying potential contact allergens.

Aims and Objectives:
The aim and objective of this study were to study the causative contact allergen in CU using the Indian Standard Battery allergens approved by the Contact and Occupational Dermatoses Forum of India and to establish the use of patch test in CU.

Materials and Methods:
One hundred clinically diagnosed cases of CU patients attended to the dermatology department for 2 years were evaluated with detailed history and clinical examination and a patch test was done using the Indian standard series. The patches were removed after 48 h and a reading was taken after 30 min. Observations were graded according to the International Contact Dermatitis Research Group recommendations.

Results:
Hospital-based prevalence of CU among patients attending the dermatology outpatient department was 3%. A positive patch test was observed in 30% of our study cases. Nickel sulfate was the most common allergen followed by fragrance mix. Patch test positivity was more in housewives, followed by farmers, teachers, and construction workers.

Conclusion:
The patch test can be used as a diagnostic investigative tool for the etiological diagnosis of CU.
Survival outcomes of epithelial ovarian cancer treated at a tertiary-level hospital in India
Authors: Chandy Rachel G. , Thomas Vinotha , Sebastian Ajit , Mani Thenmozhi , Thomas Anitha , Joel Anjana , Ram Thomas S. , Peedicayil Abraham 
Published: January 2024

Abstract

Background:
One needs to choose wisely between primary neoadjuvant chemotherapy and primary cytoreductive surgery in ovarian cancer. The aim was to determine the recurrence free survival and overall survival after surgery for epithelial ovarian cancer and also the risk factors for recurrence and death.

Methods:
Electronic medical records of 322 women operated for ovarian, fallopian or primary peritoneal cancer between 2011 and 2015 were reviewed. Descriptive statistics were used to describe patients and their clinical outcomes. Cox proportional hazard models were used for risk factor analysis. Adjusted hazard ratios were obtained for recurrence and death, adjusted for stage, primary treatment modality, residual disease and histology. Kaplan-Meier curves were drawn for probability of recurrence-free survival and overall survival. The log rank test was used to compare survival probabilities.

Results:
The majority were stage III or stage IV (78%), serous histology (71%) and high grade (64%). Primary cytoreduction was done in 48% and interval cytoreduction in 52%. The median duration of follow up (survival) was 77 months (95% CI 72-82). There were 179 known recurrences (55.6 %). The estimated median time to recurrence was 22 (95% CI 14.5- 29.5) months. The independent risk factors for recurrence were neoadjuvant chemotherapy [HR 2.14, 95% CI 1.48-3.09], stage III/IV [HR 2.75; 95% CI 1.40-5.41], high grade serous histology [HR 1.69; 95% CI 1.12-2.54] and sub-optimal debulking [HR 3.15, 95% CI 2.19-4.55]. There were 78 known deaths (24.2 %) with a mean time to death of 24.3 (SD 16.1) months. The independent risk factors for death were sub-optimal debulking [HR 3.07; 95% CI 1.78-5.29] and stages III and IV cancer [HR 3.07; 95% CI 1.14-8.27].

Conclusions:
Most ovarian cancers recur within 2 years. Risk factors for mortality are advanced stage and sub-optimal debulking. Maximal efforts at down staging and surgical resection will increase survival.
The Slitscope
Authors: Chandrakanth Prithvi , Akkara John Davis , Joshi Saloni M , Gosalia Hirika , Chandrakanth K S , Narendran V 
Published: January 2024

Abstract
Slit lamp biomicroscope is the right hand of an Ophthalmologist. Even though precise, its bulky design and complex working process are limiting constraints, making it difficult for screening at outreach camps, which are an integral part of this field for the purpose of eliminating needless blindness. The torchlight is the main tool used for screening. Recently, the integration of smartphones with instruments and the digitization of slit lamp has been explored, to provide simple and easy hacks. By bringing the slit of the slit lamp to traditional torchlight, we have created “The Slitscope”. It combines the best of both worlds as a simple innovative do-it-yourself novel technique for precise cataract screening. It is especially useful in peripheral centers, vision centers, and outreach camps. We present two prototypes which can also be 3D printed.
Hemi-retinal vein occlusion: Characterizing a rare retinal vasculopathy
Authors: Kadam Yogita , Thaku Pratima , Das Anthony Vipin , Narayanan Raja , Senthil Sirisha , Takkar Brijesh 
Published: January 2024

Abstract

Purpose:
To characterize hemi-retinal vein occlusion (HRVO) in patients presenting to a multi-tier ophthalmology hospital network.

Methods:
This retrospective, hospital-based study analyzed 2,834,616 new patients between August 2010 and June 2021. Patients with a clinical diagnosis of HRVO in at least one eye were included as cases. Data were collected using an electronic medical record system. Data were compared to the findings noted in branch RVO (BRVO) and central RVO (CRVO) patients.

Results:
HRVO constituted 0.9% (n = 191) of all the retinal vein occlusions (RVOs), with the mean age being 60.55 ± 10.14 years. Most patients were male (125, 65.45%) with unilateral (92.67%) affliction. Majority presented during the sixth (31.41%) or seventh (32.46%) decade of life. Most patients reported mild (37.07%) or moderate (27.32%) visual impairment, with vision < 20/200 being less common in HRVO (25.8%) and BRVO (17.2%) compared to CRVO (44.1%) (P < 0.00001). Glaucoma was diagnosed and treated in 49 (23.90%) eyes, which was much higher than CRVO (11.45%) and BRVO (5.04%) (P < 0.001), though neovascular glaucoma was much less than CRVO (2.9% vs. 9.2%) (P = 0.0037). On follow-up, HRVO eyes (12.2%) had lesser vision loss compared to CRVO eyes (13.7%) (this difference does not look very significant to me), though BRVO had the least (9.1%) vision loss.

Conclusion:
HRVO is a rare RVO, presenting more in males. It causes less-severe visual impairment compared to CRVO. Large majority of patients with HRVO do not have identifiable systemic risk factors other than age. Preexisting glaucoma was more associated with HRVO compared to other RVOs.
VKH disease in the elderly: Variations in clinical course as compared to VKH disease in adults
Authors: Kaza Hrishikesh , Cherukuri Navya , Tyagi Mudit , Basu Soumyava , Pappuru Rajeev R , Murthy Somasheila 
Published: January 2024

Purpose:
To describe disease characteristics and outcomes of Vogt–Koyanagi–Harada (VKH) disease in elderly patients.

Methods:
Retrospective analysis of patients older than 50 years with VKH disease at two referral centers in India. Demographics, extraocular and ocular involvement, treatment, complications, and visual acuity outcomes were noted.

Results:
In total, 69 patients (mean age at presentation: 56.4 ± 4.7 years) were analyzed; 6/69 patients had diabetes mellitus at presentation, and 10/69 had hypertension. Clinical signs included anterior chamber cells >2+ (29%), granulomatous keratic precipitates (23%), disc hyperemia (26%), neurosensory retinal detachment (34.7%), and “sunset-glow” fundus (52.1%). Patients were classified as probable (n = 50, 72.4%), incomplete (n = 18, 26%), and complete VKH (n = 1, 1.4%). The mean follow-up period was 20.2 ± 19.4 months. Improvement in mean BCVA of (0.63 LogMAR, 6 Snellen lines) was noted on the last follow-up. Patients receiving systemic steroids with immunosuppressants (P < 0.0001) had better visual outcomes at final follow-up compared to steroids alone (P = 0.103). Eight patients (11.6%) had complications due to systemic immunosuppressants, and 17 patients (24.6%) developed diabetes mellitus or had worsening of diabetes while on systemic corticosteroids.

Conclusion:
Few patients presented with systemic manifestations in our cohort. Those treated with steroids and concurrent immunosuppressants had better outcomes. However, therapy with immunosuppressants was encountered with major dose-limiting complications in a significant number of elderly patients with VKH syndrome.
Comparison of cosmesis, mydriasis, fundus visibility, and anterior chamber depth following single-pass four-throw pupilloplasty in congenital and traumatic iris defects
Authors: Singh S P , Gupta Shweta , Chaudhary Aparajita , Dwivedi Kshama , Singh Vinod K , Singh Shivangi 
Published: January 2024

Purpose:
To compare postoperative cosmesis, mydriasis, fundus visibility, and anterior chamber depth (ACD) in congenital and traumatic iris defects after single-pass four-throw pupilloplasty (SFTP).

Settings and Design:
Hospital-based non-randomized interventional study.

Methods:
SFTP was done along with phacoemulsification in six patients each with congenital and traumatic iris defects, and the patients were followed for a minimum period of 3 months. The postoperative pupil shape, size, mydriasis, and ACD were compared between the two groups.

Results:
Tissue approximation was successful in 11 out of 12 patients (91.7%), whereas it failed to do so in one patient with traumatic iris tear (8.3%). A central round pupil was attained in all six patients with congenital defects (group 1), whereas in the traumatic group (group 2), a central round pupil was attained in four cases. Group 1 did not show a significant reduction in horizontal pupil diameter, but group 2 had a significant reduction in pupil diameter postoperatively. Mydriasis and fundus visibility were satisfactory in all cases. There was a significant deepening of ACD in both groups.

Conclusion:
Traumatic mydriasis usually requires SFTP at two opposite poles to achieve a central pupil with a significant reduction in pupil size, whereas congenital coloboma requires SFTP to be done at the site of coloboma with occasional enlargement at the opposite pole if the pupil is eccentric.
Ophthalmic manifestations in hematological malignancies: An observational study from a tertiary care health center in Eastern India
Authors: Thareja Japesh , Minj Anita , Samal Priyanka , Panigrahi Pradeep Kumar 
Published: January 2024

Purpose:
This study aimed to document the spectrum of ocular manifestations of hematological malignancies presenting to a tertiary health center in Eastern India and their association with blood parameters.

Methods:
This hospital-based cross-sectional study was conducted from August 2021 to July 2022. Patients diagnosed with leukemia, lymphoma, and multiple myeloma were enrolled in the study. A comprehensive ophthalmic evaluation was done in each case.

Results:
A total of 97 patients with a confirmed diagnosis of hematological malignancies and meeting the inclusion and exclusion criteria were included in the study. Ocular manifestations were noted in 48 (49.48%) patients. Acute lymphocytic leukemia accounted for 35.4% of cases, followed by acute myeloid leukemia (31.25%), lymphoma (4.2%), and minimum manifestation in multiple myeloma (2.1%) patients. Among 48 patients with ocular manifestations, anterior segment involvement was found in 6.2% of cases, with subconjunctival hemorrhage being the most common, and the posterior segment was involved in 100% of patients, with intraretinal hemorrhages being the most common manifestation. A statistically significant association was noted between hemoglobin, total red blood cell count, and total platelet count with posterior segment manifestations (p < 0.001). On multivariable logistic regression, only total leucocyte count and total platelet count were significant predictors for ocular manifestation.

Conclusion:
Indirect involvement of the retina is the most common ocular pathology in hematological malignancies, with intraretinal hemorrhages being the most common finding. Ophthalmic examination is highly recommended as a part of the routine evaluation at the time of diagnosis of hematological malignancies and periodically thereafter to diagnose any ocular involvement.
Delayed Diagnosis of Cutaneous Larva Migrans over Face: An Unusual Case Report
Authors: Jain Kriti , Gaba Sakshi , Kar Hemanta Kumar , Bajoria Sejal , Sukhija Riya , Sethy Mitanjali 
Published: January 2024

Abstract
Cutaneous larva migrans (CLM) also known as “creeping eruption” is a parasitic zoonotic disease caused by the larval invasion and migration of soil-transmitted helminth larvae in the skin, the most common being Ancylostoma
braziliense and Ancylostoma caninum. It is more likely to occur on the feet and lower extremities. The incidence of CLM occurring over the face is relatively rare.
Dermoscopic Features of Blue Rubber Bleb Nevus Syndrome
Authors: Dhinoja Niraj , Hirma Shubhangi , Vora Rita Vipul 
Published: January 2024

Abstract
Blue rubber bleb nevus syndrome (BRBNS) usually has a sporadic onset. It is characterized as blue to purple, soft, rubbery, compressible nodules over any region in the skin or mucous membrane. It may be complicated by acute hemorrhage, iron deficiency anemia, bowel infarction, skeletal bowing, pathologic fracture, etc., Here, we present the case of a 9-year-old boy who presented with a complaint of multiple reddish to bluish nontender nodules over the tongue, chest, neck, abdomen, back, B/L upper limb, scrotum, and B/L lower limb including sole. Dermoscopic examination demonstrated red–purple globules with verrucous surface with lacunae separated by a white linear structure corresponding to fibrous demarcations. With the help of dermoscopic and clinical examination, the patient was diagnosed as having BRBNS.
Cyclosporine Monotherapy in Pediatric Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Preserving Sepsis Indicators While Promoting Recovery
Authors: Tuli Simran S. , Jain Amit , Dhamale Suyog Shashikant , Sardesai Vidyadhar R. 
Published: January 2024

Abstract
Stevens–Johnson syndrome and toxic epidermal necrolysis are severe skin reactions seen commonly following exposure to drugs. The quest for the ideal drug to treat these conditions faces significant challenges. There is an absence of head-to-head, comparative, clinical, double-blinded trials comparing the various disease-modifying agents, owing to the rarity and severity of these conditions, along with ethical issues. In such a scenario, gathering data through clinical experiences can provide valuable insights for formulating future guidelines and improving the quality of care. The following case highlights the potential of cyclosporine A to preserve sepsis signs while demonstrating therapeutic efficacy, adding to the growing body of evidence in its favor.
The curious case of milk collection under skin graft over the breast: Lessons learned!
Authors: Karmakar S , Kala PC , Humnekar A 
Published: January 2024

Abstract
Raw area on the breast, especially when it is lactating, can lead to complications, including hyperprolactinemia and development of milk fistulae. A 25-year-old female presented with raw area over the left breast after 2 months of childbirth. She had history suggestive of necrotizing disease, which had primarily been managed elsewhere with debridement and dressings. We excised the raw area and applied split thickness skin grafts with minimal meshing. Bulky dressing prevented breastfeeding. On postoperative day 3, there were blebs containing milk underneath the graft. The blebs were drained and oral cabergoline was administered for 3 months. The skin graft healed well. If expression of breast milk is not possible then suppression of lactation should be considered before definitive cover of the raw area of breast.