bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning activities of students with hearing disabilities in the digital environment: features, problems and styles
Authors: Ponomarenko E. P. , Krasavina Yu. V. , Gareyev A. A. , Shishkina A. A. 
Published: December 2023

Due to the development of digitalization in education, it is important to study the potential of the digital environment in the training of students with hearing disabilities. The primary task is to study the features of learning activities of students with this pathology in interaction with the digital environment and the impact of active use of digital technologies on students’ cognitive sphere to optimize the conditions of digital learning and prevent its negative impact.The views on the properties of the human cognitive sphere developing in the conditions of deafness, including the peculiarities of working memory, have been analyzed. A brief review of research on the organization of e-learning for hearing impaired and deaf students of different countries during the pandemic period was carried out. Special attention is paid to the problems of transition to distance learning and the risks of cognitive performance in the digital environment for students with hearing loss.The results of the study of cognitive difficulties of students with hearing disabilities in the digital environment and their cognitive styles are presented. Based on the analysis of in-depth interviews data, motivational, cognitive, activity, organizational, and technical problems are formulated. Using the grounded theory method, three learning styles were identified: proactive, practical, and passive. Knowing the distinctive features of each style will allow creating of more personalized learning systems as part of the digitalization of inclusive education.
About the methods of the students competences analysis in distance and blended learning
Authors: Savin M. A. 
Published: December 2023

The rapid development of distance and blended learning formats poses a serious problem for instructors to objectively and reliably assess students’ knowledge. Modern learning management systems often do not provide comprehensive information about the quality of learning in a convenient form for the teacher. A brief review of the leading distance learning systems used in universities of the Russian Federation allows us to make sure of this. The capabilities of popular learning management systems, their advantages and disadvantages in processing information about students’ progress are analyzed. According to the results of the analysis, the necessity of further custom data processing becomes obvious.The methodology of evaluating the quality of students’ knowledge is shown in the example of an own development — the Abins.NET learning management system created at Perm National Research Polytechnic University. The necessity of using a minimum of two independent criteria for evaluating the quality of learning by conducting a correlation analysis between the grade, work time, and bonus points is confirmed.The comparison of bonus points accrual methods in own-developed learning management system, iSpring, and WebTutor was carried out and the conclusion was made about the necessity of automated bonus management (accrual, write-off) according to the criteria that are predetermined by the developer. The conclusions and suggestions on the selection of significant criteria and their calculation when working with any learning management system to assess the success of university students’ learning are formulated.
EVALUASI TATA KELOLA TEKNOLOGI INFORMASI MENGGUNAKAN FRAMEWORK BALANCED SCORECARD DAN COBIT 5
Authors: Ayu Andini Dwi Yana , Aziz R.Z.  Abdul 
Published: December 2023

Pemanfaatan Teknologi Informasi (TI) merupakan sebagian penting dan sangat dibutuhkan di hampir semua sektor bisnis termasuk institusi Perguruan Tinggi atau Universitas. Tata kelola TI yang tepat dan sesuai kebutuhan instansi sangat diperlukan untuk menjamin efisiensi dan tercapainya kualitas layanan yang baik. Tetapi saat ini masih sering terjadi ketidaksesuaian dalam penggunaan teknologi informasi yaitu kurangnya efektifitas bimbingan teknis terkait penggunaan teknologi informasi, masalah virus yang mengakibatkan hilangnya data-data, dan kegagalan sistem yang terjadi secara tidak terduga. Dengan kondisi tersebut, dibutuhkan evaluasi tata kelola teknologi informasi dimana pada akhirnya dapat membuahkan hasil temuan serta rekomendasi yang dapat menjadi masukan bagi UAP guna peningkatan pengelolaan IT. Metode yang digunakan yaitu framework Balanced Scorecard untuk melakukan identifikasi antara tujuan strategis perusahaan dengan keempat perspektif yang terdapat dalam Balanced Scorecard yaitu financial, internal, custimer, learning and growth. Kemudian dilakukan identifikasi enterprise goals dengan COBIT 5 yang terpilih. Temuan analisis kuesioner untuk responden manajemen dan pengguna mendapatkan nilai current rata-rata pada proses EDM03, EDM04, APO01, APO04, APO07, APO13, BAI05, dan DSS02 yaitu 2,77 yang berarti hasil penialain pada sistem informasi akademik UAP memiliki capability level 3 (established).
A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus
Authors: Ahmed abed Baydaa , Othman Farhan Layla , Noori Salman Isam , Ehssan Safaa 
Published: December 2023

Adipokines are essential for maintaining cardiovascular and metabolic balance. The term "adipokines" refers to peptides in the pancreas, brain, vascular system, liver, immune system and muscle. adipokines regulate numbers of factors, such as energy expenditure, hunger, satiety, insulin sensitivity, and blood pressure, insulin secretion, adipogenesis and fat distribution, and that might make them play a role in future pharmacological treatment strategies for obesity and metabolic diseases. Isthmin-1 (Ism-1) is a recently discovered insulin-like adipokine that suppresses hepatic lipids. According to recent research, Ism-1 can enhance lipid metabolism and treat metabolic disorders linked to type 2 diabetic mellitus (T2DM). The primary source of the protein subfatin (SUB) is white adipose tissue. Subfatin (SUB) is expressed in these following tissues: adipose tissue, brain tissue, thymus gland, liver, activated human monocytes, spleen, omental adipose tissue, muscle, salivary glands and heart tissues. The SUB lowers insulin resistance to control glucose metabolism. Isthmian-1 is a novel biomarker for early management and diagnosis of T2DM and has a beneficial effect in glucose homeostasis and might be therapeutic for diabetes. Subfatin also plays a role in glucose metabolism and insulin sensitivity, so it has significant effect in pathogenesis and complication of diabetes.
The age and sources of stream water in a boreal forest watershed in the permafrost region: a case study of a watershed in northeast China
Authors: Xiao Xiang , Cai Tijiu , Duan Liangliang 
Published: December 2023

Determining the age and sources of stream water is critical for understanding the watershed hydrological processes and biogeochemical cycle. In this study, daily isotope data of rainfall and runoff, as well as continuously monitored conductivity data from June to October in 2019 in-Laoyeling(LYL) watershed located in permafrost region of northeastern China were used to separate streamflow components through the application of two independent methods: isotope-based hydrograph separations (IHS) and the conductivity mass balance (CMB) methods. The results showed that stream water in a boreal forest watershed with permafrost of the Daxing’an Mountains is mainly composed of pre-event water. Although the IHS method is more sensitive and provides more details than the CMB method, the results of both methods show a similar trend. The average value of the young water fractions (Fyw) for those aged less than 65 days is 5.6%, while the mean transit time (MTT) was calculated to be 3.33 years. These findings enhance our understanding of the fundamental characteristics of runoff generation mechanisms and changes in runoff components in permafrost regions. Such knowledge is crucial for effective regional water resource management under the context of climate change, such as construction of water conservancy facilities and prediction of flood and drought disasters.
Analysis and quantitative identification of guided wave propagation mechanism in concrete
Authors: Su Chenhui , Zhang Yuhang , Tang Lin , Zhang Wenchao 
Published: December 2023

Concrete is widely used in bridges, tunnels, nuclear power plants and other buildings, the damage of concrete will bring significant safety hazards for the building, therefore, detecting concrete damage is of great significance. In this paper, the propagation characteristics of guided waves in concrete plates are investigated, and finite element simulation is used to analyze the sensitivity of guided waves to the damage of concrete materials under different excitation frequencies. Simulation experiments on guided wave propagation are performed on concrete materials containing damage in the excitation frequency range from 25 to 100 kHz. The signals received by the sensors are analyzed in the time domain, while the reflected wave signals resulting from the contact of the signals with the damage are analyzed in the frequency domain. The results show that the excitation frequencies of 25 and 60 kHz are more sensitive to damage, and the quantitative identification of damage without reference can be realized by using the peak signals in the frequency domain at different excitation frequencies.
Ultrasonographic manifestations and misdiagnosis analysis of ovarian leiomyoma
Authors: Zhang Min , Hong Yan , Wang Li , Qin Ling-Ling , Jing Xiang-xiang 
Published: December 2023

ObjectivesOvarian leiomyomas (OLs) are rare and account for only 0.5 to 1% of benign ovarian tumors. This study investigated the ultrasonographic manifestations of OL and the potential reasons for misdiagnosis.MethodsBetween July 2018 and July 2023, 7 patients diagnosed with OL by surgical pathology and immunohistochemistry were enrolled in this retrospective analysis. Ultrasound (US) examinations were performed before surgery. Clinical characteristics, pathological findings, ultrasonographic manifestations, and treatment were reviewed.ResultsThe mean age of the 7 patients was 39.0 ± 11.57 years, with a disease course of 0.1 to 24 months. All ovarian leiomyomas were unilateral. Four cases occurred in the right ovary, and three cases occurred in the left ovary. All lesions presented as hypoechogenic, well-circumscribed, round or oval in shape, and regular in morphology. No significant blood flow signal was detected peripheral to or inside the mass in 3 cases (42.8%), and a minimal flow signal was detected peripheral to or inside the mass in 4 cases (58.2%). A total of 7 ultrasonographic images of OL were misdiagnosed: 1 patient was misdiagnosed with subserosal uterine leiomyoma, and 6 patients were misdiagnosed with a tumor in the ovarian thecoma–fibroma group.ConclusionThe imaging manifestation of OL lacks specificity; thus, preoperatively distinguishing OL from other ovarian tumors and subserosal uterine leiomyomas is difficult. Immunohistochemistry may be helpful for the definitive diagnosis of OL. The possibility of ovarian leiomyoma should be considered in patients with uterine leiomyomas coexisting with an adnexal ovarian solid mass.
Pemphigus: trigger and predisposing factors
Authors: Moro Francesco , Sinagra Jo Linda Maria , Salemme Adele , Fania Luca , Mariotti Feliciana , Pira Anna , Didona Biagio , Di Zenzo Giovanni 
Published: December 2023

Pemphigus is a life-threatening autoimmune blistering disease affecting skin and mucous membranes. Despite its etiopathogenesis remains largely unknown, several trigger and predisposing factors have been reported. Pemphigus is caused by autoantibodies that target desmoglein 1 and desmoglein 3, impacting desmosome function. However, circulating autoantibodies are often the consequence of a precipitating factor that occurs in predisposed individuals. This review aims to describe and discuss almost all trigger and predisposing factors reported as possible or probable cause of the disease. Among the reported trigger factors that may induce or exacerbate pemphigus, we have found of particular interest: drug intake (especially thiol- and phenol-containing compounds), vaccines, infections, as well as some reports about pregnancy, radiations, emotional stress, pesticides and physical trauma. Moreover, we discuss the possible role of food intake in pemphigus onset and particular attention is given to dietary factors containing thiol, phenol and tannin compounds. A trigger factor is “the straw that breaks the camel’s back,” and often acts together with predisposing factors. Here we discuss how pemphigus onset may be influenced by genetic susceptibility and comorbidities like thyroid diseases, malignancies and other autoimmune disorders.To identify other hitherto unknown trigger and predisposing factors, well designed prospective studies are needed. In this context, future research should explore their connection with the aim to advance our understanding of pemphigus pathogenesis.
Research on the quality markers of antioxidant activity of Kai-Xin-San based on the spectrum–effect relationship
Authors: Shan Xiaoxiao , Yang Xuan , Li Dawei , Zhou Lele , Qin Shaogang , Li Junying , Tao Wenkang , Peng Can , Wei Jinming , Chu Xiaoqin , Wang Haixuan , Zhang Caiyun 
Published: December 2023

Background: Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidant activity. However, the antioxidant material basis and quality markers (Q-makers) of KXS have not been studied. Objective: The objective of this study is to explore the Q-makers of antioxidant activity of KXS based on spectrum-effect relationship.Methods: Specifically, the metabolites in KXS extracts were identified by UPLC-Q-Exactive Orbitrap MS/MS. The fingerprint profile of KXS extracts were established by high-performance liquid chromatography (HPLC) and seven common peaks were identified. Meanwhile, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test was used to evaluate the free radical scavenging ability of KXS. The spectrum-effect relationship between its HPLC fingerprint and DPPH free radical scavenging activity was preliminarily examined by the Pearson correlation analysis, grey relation analysis (GRA), and orthogonal partial least squares discrimination analysis (OPLS-DA). Further, the antioxidant effect of KXS and its Q-makers were validated through human neuroblastoma (SH-SY5Y) cells experiment.Results: The results showed that 103 metabolites were identified from KXS, and the similarity values between HPLC fingerprint of twelve batches of KXS were greater than 0.900. At the same time, the results of Pearson correlation analysis showed that the peaks 8, 1, 14, 17, 18, 24, 16, 21, 15, 13, 6, 5, and 3 from KXS were positively correlated with the scavenging activity values of DPPH. Combined with the results of GRA and OPLS-DA, peaks 1, 3, 5 (Sibiricose A6), 6, 13 (Ginsenoside Rg1), 15, and 24 in the fingerprints were screen out as the potential Q-makers of KXS for antioxidant effect. Besides, the results of CCK-8 assay showed that KXS and its Q-makers remarkably reduced the oxidative damage of SH-SY5Y cells caused by H2O2. However, the antioxidant activity of KXS was decreased significantly after Q-makers were knocked out.Conclusion: In conclusion, the metabolites in KXS were successfully identified by UPLC-Q-Exactive Orbitrap MS/MS, and the Q-makers of KXS for antioxidant effect was analyzed based on the spectrum-effect relationship. These results are beneficial to clarify the antioxidant material basis of KXS and provide the quality control standards for new KXS products development.
Variety ACEs and risk of developing anxiety, depression, or anxiety-depression co-morbidity: the 2006–2022 UK Biobank data
Authors: Yu Peilin , Jiang Zhou , Zheng Chu , Zeng Ping , Huang Lihong , Jin Yingliang , Wang Ke 
Published: December 2023

ObjectivesAdverse childhood experiences (ACEs) and anxiety-depression co-morbidity are attracting widespread attention. Previous studies have shown the relationship between individual psychiatric disorders and ACEs. This study will analyze the correlation between anxiety-depression co-morbidity and different levels of ACEs.MethodsSeven categories of ACE and four classifications of psychiatric disorders were defined in a sample of 126,064 participants identified by the UK Biobank from 2006–2022, and correlations were investigated using logistic regression models. Then, to explore nonlinear relationships, restricted spline models were developed to examine differences in sex and age across cohorts (n = 126,064 for the full cohort and n = 121,934 for the European cohort). Finally, the impact of the category of ACEs on psychiatric disorders was examined.ResultsAfter controlling for confounders, ACEs scores showed dose-dependent relationships with depression, anxiety, anxiety-depression co-morbidity, and at least one (any of the first three outcomes) in all models. ACEs with different scores were significantly positively correlated with the four psychiatric disorders classifications, with the highest odds of anxiety-depression co-morbidity (odds ratio [OR] = 4.87, 95% confidence intervals [CI]: 4.37 ~ 5.43), p = 6.08 × 10−178. In the restricted cubic spline models, the risk was relatively flat for females at ACEs = 0–1 and males at ACEs = 0–2/3 (except in males, where ACEs were associated with a lower risk of anxiety, all other psychiatric disorders had an increased risk of morbidity after risk smoothing). In addition, the risk of having anxiety, depression, anxiety-depression co-morbidity, and at least one of these disorders varies with each category of ACEs.ConclusionThe prevalence of anxiety-depression comorbidity was highest across ACE scores after controlling for confounding factors and had a significant effect on each category of ACEs.
Is the Invasive Plant Amaranthus spinosus L. More Competitive than the Native Plant A. tricolor L. When Exposed to Acid Deposition with Different Sulfur–Nitrogen Ratios?
Authors: Li Yue , Li Chuang , Zhong Shanshan , Xu Zhelun , Liu Jun , Xu Zhongyi , Zhu Mawei , Wang Congyan , Du Daolin 
Published: December 2023

The functional differences between invasive plants and coexisting native plants can affect the invasion process of the former because invasive plants and coexisting native plants are exposed to similar or even identical environmental pressures. Acid deposition is an important component of atmospheric pollution, and acid deposition with different sulfur–nitrogen ratios may affect the invasion process of invasive plants by shifting the functional differences and differences in the growth performance between the invasive and coexisting native plants. It is crucial to analyze the functional indices and growth performance of these plants when exposed to acid deposition with different chemical compositions to assess the ecological impacts of atmospheric pollution on the growth performance of invasive plants. This study aimed to evaluate the functional differences and growth performance between the invasive plant Amaranthus spinosus L. and the native plant A. tricolor L. in mono- and mixed culture when exposed to an acid deposition with different sulfur–nitrogen ratios, including sulfur-rich acid deposition (sulfur–nitrogen ratio = 5:1), nitrogen-rich acid deposition (sulfur–nitrogen ratio = 1:5), and mixed acid deposition (sulfur–nitrogen ratio = 1:1). The acidity of the three types of simulated acid deposition was set at pH = 5.6 and pH = 4.5, respectively, with distilled water as a control (pH = 7.0). The competition experiment between A. spinosus and A. tricolor was conducted in the greenhouse. Amaranthus spinosus exhibited a strong growth performance over A. tricolor in the mixed culture, mainly via the increased leaf photosynthetic capacity. The competitiveness for light acquisition, leaf photosynthetic capacity, and enzymatic defense capacity under stress of A. spinosus may be vital to its growth performance. The lower pH acid deposition had imposed a greater reduction in the growth performance of both Amaranthus species than the higher pH acid deposition. Sulfur-rich acid deposition was more toxic to the growth performance of both Amaranthus species than nitrogen-rich acid deposition. Amaranthus spinosus was more competitive than A. tricolor, especially when exposed to acid deposition, compared with just distilled water. Thus, acid deposition, regardless of the sulfur–nitrogen ratio, may facilitate the invasion process of A. spinosus via the stronger growth performance.
Comprehensive Recovery of Point Defect Displacement Field Function in Crystals by Computer X-ray Diffraction Microtomography
Authors: Chukhovskii Felix N. , Konarev Petr V. , Volkov Vladimir V. 
Published: December 2023

In the case of the point defect in a crystal, the inverse Radon’s problem in X-ray diffraction microtomography has been solved. As is known, the crystal-lattice defect displacement field function f(r) = h·u(r) determines phases − (±h)-structure factors incorporated into the Takagi–Taupin equations and provides the 2D image patterns by diffracted and transmitted waves propagating through a crystal (h is the diffraction vector and u(r) is the displacement field crystal-lattice-defects vector). Beyond the semi-kinematical approach for obtaining the analytical problem solution, the difference-equations-scheme of the Takagi–Taupin equations that, in turn, yield numerically controlled-accuracy problem solutions has been first applied and tested. Addressing the inverse Radon’s problem solution, the χ2-target function optimization method using the Nelder–Mead algorithm has been employed and tested in an example of recovering the Coulomb-type point defect structure in a crystal Si(111). As has been shown in the cases of the 2D noise-free fractional and integrated image patterns, based on the Takagi–Taupin solutions in the semi-kinematical and difference-scheme approaches, both procedures provide the χ2-target function global minimum, even if the starting-values of the point-defect vector P1 is chosen rather far away from the reference up to 40% in relative units. In the cases of the 2D Poisson-noise image patterns with noise levels up to 5%, the figures-of-merit values of the optimization procedures by the Nelder–Mead algorithm turn out to be high enough; the lucky trials number is 85%; and in contrast, for the statistically denoised 2D image patterns, they reach 0.1%.
Living Algal Community Voucher and Taxonomy in Dickinson County Iowa: A Case for Collection-Based Research
Authors: Johnson Katherine M. , Manoylov Kalina M. 
Published: December 2023

Integrative taxonomy is necessary for advancing the field of phycology and understanding regional algal diversity. Collection-based studies for the purposes of providing descriptive voucher flora of living algal communities inform future long-term monitoring and genetic barcoding studies. In this study, littoral composite samples were taken from eight sites (Center Lake, Emerson Bay, Freda Haffner Kettlehole State Preserve, Millers Bay, East Okoboji Lake, West Okoboji Lake, Big Spirit Lake, Upper Gar Lake) in Dickinson County, Iowa, for the purposes of fine level taxonomy. This region has a history of eutrophication, and algal blooms have caused Iowa water resource issues in the past. Micrography for these voucher floras was conducted for taxa representing at least 10% or more of the total estimated algal biomass of evaluated slides. Our voucher floras comprise micrographs of living cells across nine different algal groups and 54 unique taxonomic entities. Unique taxa from these sites include Glaucocystis nostochinearum Itzigsohn, Draparnaldia acuta (C.Agardh) Kützing, and Chaetophoropsis elegans (Roth) B. Wen Liu, Qian Xiong, X.Dong Liu, Z. Yu Hu & G. Xiang Liu. We also document species belonging to toxin-producing Cyanobacteria genera Mycrocystis and Dolichospermum.