bluuebunny/crossref_metadata_2025_split huggingface dataset:
Filling the gap between GRACE and GRACE follow-on observations based on principal component analysis
Authors: Gu Yanchao , Huang Feilong , Huang Jun , Yuan Hongbo , Yu Bing , Gao Chongqin 
Published: December 2023

SUMMARY
The Gravity Recovery and Climate Experiment (GRACE) and its successor, GRACE Follow-On (GRACE-FO), have revolutionized the approach to monitoring global mass variations. However, the presence of several gaps, notably the continuous 11-month gap between the two missions, has generated a disruption in observations and hindered the analysis and application of the data. To address this problem, we have proposed a spectral domain gap-filling approach based on principal component analysis (PCA). Our simulation experiments demonstrate that the PCA gap-filling technique has significant potential to successfully reconstruct global mass variation and accurately capture real signals for most basins with an accuracy of less than 2 cm. When applied to actual missing data, our methodology delivers highly consistent results with previously published filling approaches, such as singular spectrum analysis and improved multichannel singular spectrum analysis method, for most of the global basins. Noteworthy, in the case of the Nelson basin, our PCA gap-filling method outperforms other methods in capturing seasonal signals and the return to a normal level of the terrestrial water storage changes in 2018. A comparison in the spectral domain indicates that the accuracy of the PCA-filling output is comparable to the original GRACE(-FO) data. Moreover, our method exhibits high generality, allowing for direct application to continuous GRACE(-FO) data without other additional data processing and without differentiating the types of missing data. Therefore, the proposed PCA gap-filling method offers exciting opportunities to guarantee the continuity of global mass change observations and benefit subsequent applications that require continuous data records.
“The last Jew in Vinnitsa”: Reframing an Iconic Holocaust Photograph
Authors: Matthäus Jürgen 
Published: December 2023

Abstract
As scholarly sources, images require critical engagement to unlock their evidential and explanatory potential beyond what seems visually apparent. Based on newly available documentation, this research note offers corrective evidence and contextual explication for a more historically accurate as well as interdisciplinarity rewarding reading of one iconic Holocaust photograph known as “The Last Jew in Vinnitsa.”
Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function
Authors: Ikegami Shuji , Maeda Keiko , Urano Takeshi , Mu Jingxi , Nakamura Masanao , Yamamura Takeshi , Sawada Tsunaki , Ishikawa Eri , Yamamoto Kenta , Muto Hisanori , Oishi Akina , Iida Tadashi , Mizutani Yasuyuki , Ishikawa Takuya , Kakushima Naomi , Furukawa Kazuhiro , Ohno Eizaburo , Honda Takashi , Ishigami Masatoshi , Kawashima Hiroki 
Published: December 2023

Abstract

Background
Antitumor necrosis factor (TNF)-α antibodies have improved the outcome of inflammatory bowel disease (IBD); but half of patients remain unresponsive to treatment. Interleukin-18 (IL-18) gene polymorphism is associated with resistance to anti-TNF-α antibodies, but therapies targeting IL-18 have not been clinically applied. Only the mature protein is biologically active, and we aimed to investigate whether specific inhibition of mature IL-18 using a monoclonal antibody (mAb) against a neoepitope of caspase-cleaved mature IL-18 could be an innovative treatment for IBD.

Methods
The expression of precursor and mature IL-18 in patients with UC was examined. Colitis was induced in C57/BL6 mice by administering dextran sulfate sodium (DSS), followed by injection with anti-IL-18 neoepitope mAb. Colon tissues were collected and subjected to histological analysis, immunohistochemistry, immunoblotting, and quantitative polymerase chain reaction. Colon epithelial permeability and microbiota composition were analyzed.

Results
Mature IL-18 expression was elevated in colon tissues of patients with active ulcerative colitis. Administration of anti-IL-18 neoepitope mAb ameliorated acute and chronic DSS-induced colitis; reduced interferon-γ, TNF-α, and chemokine (CXC motif) ligand-2 production and epithelial cell permeability; promoted goblet cell function; and altered the intestinal microbiome composition. The suppressive effect of anti-IL-18 neoepitope mAb was superior to that of anti-whole IL-18 mAb. Furthermore, combination therapy with anti-TNF-α Ab suppressed acute and chronic colitis additively by suppressing cytokine expressions and reducing cell permeability by upregulating claudin1 and occludin expression.

Conclusions
Anti-IL-18 neoepitope mAb ameliorates acute and chronic colitis, suggesting that this mAb will be an innovative therapeutic option for IBD.
Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats
Authors: Kurban Nurhumar , Qin Yu , Zhao Hui-Ling , Hu Xiao , Chen Xi , Zhao Yi-Yi , Peng Yu-Shuo , Wang Hong-Bo , Cui Su-Ying , Zhang Yong-He 
Published: December 2023

Abstract

Background
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that projects throughout the central nervous system, including the noradrenergic locus coeruleus (LC). Our previous study suggested that MCH/MCH receptor 1 (MCHR1) in the LC may be involved in the regulation of depression. The present study investigated whether the role of MCH/MCHR1 in the LC in depression-like behaviors is associated with the regulation of norepinephrine.

Method
Chronic unpredictable stress (CUS) and an acute intra-LC microinjection of MCH induced depression-like behaviors in rats. The MCHR1 antagonist SNAP-94847 was also microinjected in the LC in rats that were suffering CUS or treated with MCH. The sucrose preference, forced swim, and locomotor tests were used for behavioral evaluation. Immunofluorescence staining, enzyme-linked immunosorbent assay, western blot, and high-performance liquid chromatography with electrochemical detection were used to explore the mechanism of MCH/MCHR1 in the regulation of depression-like behaviors.

Results
CUS induced an abnormal elevation of MCH levels and downregulated MCHR1 in the LC, which was highly correlated with the formation of depression-like behaviors. SNAP-94847 exerted antidepressant effects in CUS-exposed rats by normalizing tyrosine hydroxylase, dopamine β hydroxylase, and norepinephrine in the LC. An acute microinjection of MCH induced depression-like behaviors through its action on MCHR1. MCHR1 antagonism in the LC significantly reversed the MCH-induced downregulation of norepinephrine production by normalizing MCHR1-medicated cAMP-PKA signaling.

Conclusions
Our study confirmed that the MCH/MCHR1 system in the LC may be involved in depression-like behaviors by downregulating norepinephrine production. These results improve our understanding of the pathogenesis of depression that is related to the MCH/MCHR1 system in the LC.
An Implied Term of Procedural Fairness During Disciplinary Processes: Into Contracts of Employment and Beyond?
Authors: Collins Philippa , Golding Gabrielle 
Published: December 2023

Abstract
The implication of a new term by law into contracts of employment is significant and relatively rare. In somewhat of a revelation, members of the Court of Appeal in Burn v Alder Hey Children’s NHS Foundation Trust were receptive to the introduction of a duty that would require employers to act in accordance with procedural fairness during disciplinary processes. This article offers the first detailed examination of this development, commencing by exploring the nature, scope and necessity of such a term in the context of contracts of employment. The relationship between this emergent duty and the ‘Johnson exclusion zone’, which limits the remedies available at common law if the breach of the employer’s obligations alleged is the manner or fact of an employee’s dismissal, will be considered. We argue that the real potential of this duty lies in the prospect that it could be extended beyond contracts of employment and implied into, for example, contracts between workers and their employers. Such a development would be novel for the common law and make a substantial contribution to the regulation of a wider category of working relationships and to the pursuit of the objectives and aims of employment law.
Respiratory Syncytial Virus Infects Peripheral and Spinal Nerves and Induces Chemokine-Mediated Neuropathy
Authors: Pollard Kevin J , Traina-Dorge Vicki , Medearis Stephen M , Bosak Alexander , Bix Gregory J , Moore Michael J , Piedimonte Giovanni 
Published: December 2023

Abstract
Respiratory syncytial virus (RSV) primarily infects the respiratory epithelium, but growing evidence suggests that it may also be responsible for neurologic sequelae. In 3-dimensional microphysiologic peripheral nerve cultures, RSV infected neurons, macrophages, and dendritic cells along 2 distinct trajectories depending on the initial viral load. Low-level infection was transient, primarily involved macrophages, and induced moderate chemokine release with transient neural hypersensitivity. Infection with higher viral loads was persistent, infected neuronal cells in addition to monocytes, and induced robust chemokine release followed by progressive neurotoxicity. In spinal cord cultures, RSV infected microglia and dendritic cells but not neurons, producing a moderate chemokine expression pattern. The persistence of infection was variable but could be identified in dendritic cells as long as 30 days postinoculation. This study suggests that RSV can disrupt neuronal function directly through infection of peripheral neurons and indirectly through infection of resident monocytes and that inflammatory chemokines likely mediate both mechanisms.
Making International Things:Designing World Politics Differently
Authors: Austin Jonathan Luke , Leander Anna 
Published: December 2023

AbstractCan we make international things—maps, algorithms, museums, visualizations, computer games, virtual reality tools? Objects that criss-cross global space, exert political influence, and produce novel forms of knowledge? This article, and the special issue it introduces, suggests that scholars of international relations can and should engage in the task of making concrete material, aesthetic, and technological objects that exceed the epistemic, logocentric, or textual. It joins a growing conversation focused on the potential of expanding the praxis of the social sciences into multimodal formats of design, craft, and making. In this article, we explore the intellectual, social, and political stakes of beginning to make international things, unpack the disciplinary reticence to engage in this task, and the potential dangers it entails. Most importantly, we suggest five central benefits moving in this direction holds: (i) generating a future-oriented social science; (ii) cultivating an “atmospheric” social science faithful to new materialist, feminist, and practice theories; (ii) embracing a radical collaborationist ethos more-suited to the demands of the day; (iv) investing us in sociopolitically committed scientific praxis; and (v) inaugurating a radically new disciplinary architecture of scholarly praxis.
Elucidating the potential of chlorogenic acid for controlling Morganella psychrotolerans growth and histamine formation
Authors: Wang Di , Zhao Yongqiang , Chen Shengjun , Wei Ya , Yang Xianqing , Li Chunsheng , Wang Yueqi 
Published: December 2023

Abstract

Aim
To investigate the inhibitory impact of chlorogenic acid (CGA) on the growth of Morganella psychrotolerans and its ability to form histamine.

Methods and Results
The antimicrobial effect of CGA on M. psychrotolerans was evaluated using the minimum inhibitory concentration (MIC) method, revealing an MIC value of 10 mg ml−1. The alkaline phosphatase (AKP) activity, cell membrane potential, and scanning electron microscopy images revealed that CGA treatment disrupted cell structure and cell membrane. Moreover, CGA treatment led to a dose-dependent decrease in crude histidine decarboxylase (HDC) activity and gene expression of histidine decarboxylase (hdc). Molecular docking analysis demonstrated that CGA interacted with HDC through hydrogen bonds. Furthermore, in situ investigation confirmed the efficacy of CGA in controlling the growth of M. psychrotolerans and significantly reducing histamine formation in raw tuna.

Conclusion
CGA had good activity in controlling the growth of M. psychrotolerans and histamine formation.
Variation in Botanical Reference Materials: Similarity of Actaea Racemosa Analyzed by Flow Injection Mass Spectrometry
Authors: Harnly James , Upton Roy 
Published: December 2023

Abstract

Background
Botanical reference materials (BRMs) generally account for the species, cultivar, and year and location of harvest that result in variability in the chemical composition that may lead to statistically significant differences using chemometric methods.

Objective
To compare the chemical composition of five species of Actaea root BRMs, four herbal sources of A. racemosa root BRMs, and A. racemosa BRMS, and commercial roots and supplements using chemometric methods and selected pre-processing approaches.

Method
Samples were analyzed by flow injection mass spectrometry (FIMS), principal component analysis (PCA), and factorial multivariate analysis of variance (mANOVA).

Results
Statistically significant (P = 0.05) compositional differences were found between three genera (Actaea, Panax, and Ginkgo), five species of Actaea (A. racemosa, A. cimicifuga, A. dahurica, A. pachypoda, and A. rubra) root BRMs, four herbal sources of A. racemosa root BRMs, and A. racemosa BRMS and commercial roots and supplements. The variability of 6% of the BRM variables was found to be quantitatively conserved and reduced the compositional differences between the four sources of root BRMs. Compositional overlap of A. racemosa and other Actaea BRMs was influenced by variation in technical repeats, pre-processing methods, selection of variables, and selection of confidence limits. Sensitivity ranged from 94 to 97% and specificity ranged from 21 to 89% for the pre-processing protocols tested.

Conclusions
Environmental, genetic, and chemometric factors can influence discrimination between species and authentic botanical reference materials.

Highlights
Frequency distribution plots derived from soft independent modeling of class analogy provide excellent means for understanding the impact of experimental factors.
Is there a right time for dairy Alpine goat kid weaning: How does the weaning age of dairy Alpine goat kids affect their growth and behavior?
Authors: Bélanger-Naud Stéphanie , Wolfe Tania , Zambelis Athena , Lévesque Janie , Julien Carl , Vasseur Elsa 
Published: December 2023

Abstract
In dairy goat kids, weaning is often associated with poor growth leading to a decline in welfare and performance; however, little is known about optimal weaning practices. This study aimed to determine the optimal weaning age for dairy goat kids to maximize outcome measures of welfare related to growth, feed intake, and behavior. Thirty-six newborn female Alpine kids were blocked by weight and birth date, paired with a similar male companion and randomly allocated to one of the three weaning age treatments: 6 (6W), 8 (8W), and 10 wk (10W). Kids had ad libitum access to acidified milk replacer refilled twice daily, concentrates, hay, and water. Milk consumption was measured daily, and concentrate consumption, weekly. Ten behaviors were live observed on days −8, −4, 0, 6, and 12 relative to weaning (i.e., weaning day = 0). Kruskal–Wallis tests were used to assess differences from baseline between the 6W, 8W, and 10W treatments. Post hoc analysis using the Dwass, Steel, Critchlow-Fligner (DSCF) multiple comparison analysis was used to evaluate pairwise treatment differences based on two-sample Wilcoxon comparisons. Kids weaned at 10 wk had the greatest increase compared to baseline in concentrate consumption (P = 0.0160), and greatest decrease compared to baseline in vocalization (P = 0.0008) while both 8- and 10- wk kid’s groups had the greatest increase compared to baseline in self-grooming time (P &lt; 0.0001), and cross-sucking time (P = 0.0006). Kids weaned at 6 wk of age were found to have the smallest increase compared to baseline in concentrate consumption (P = 0.0160) and self-grooming time (P &lt; 0.0001), and the greatest increase compared to baseline in allogrooming time (P = 0.0032) and in redirected behaviors aimed towards the environment (biting and licking time [P = 0.0173]; displacement at the nipple frequency [P = 0.0236]). No negative impact of weaning on growth of either group was identified. Overall, our results tend towards a higher degree of discomfort behaviors (allogrooming, biting/licking, displacement, and vocalizations) in kids weaned earlier compared to later weaning, while kids weaned later showed higher levels of positive behaviors (lying time and self-grooming).
Vitamin D Deficiency Is Associated With Increased Length of Stay After Acute Burn Injury: A Multicenter Analysis
Authors: Zavala Sarah , Pape Kate O , Walroth Todd A , Reger Melissa , Hoyte Brittany , Thomas Wendy , Adams Beatrice , Hill David M 
Published: December 2023

Abstract
In burn patients, vitamin D deficiency has been associated with increased incidence of sepsis and infectious complications. The objective of this study was to assess the impact of vitamin D deficiency in adult burn patients on hospital length of stay (LOS). This was a multicenter retrospective study of adult patients at 7 burn centers admitted over a 3.5-year period, who had a 25-hydroxyvitamin D concentration drawn within the first 7 days of injury. Of 1147 patients screened, 412 were included. Fifty-seven percent were vitamin D deficient. Patients with vitamin D deficiency had longer LOS (18.0 vs 12.0 days, P &lt; .001), acute kidney injury (AKI) requiring renal replacement therapy (7.3 vs 1.7%, P = .009), more days requiring vasopressors (mean 1.24 vs 0.58 days, P = .008), and fewer ventilator-free days of the first 28 days (mean 22.9 vs 25.1, P &lt; .001). Univariable analysis identified burn center, AKI, TBSA, inhalation injury, admission concentration, days until concentration drawn, days until initiating supplementation, and dose as significantly associated with LOS. After controlling for center, TBSA, age, and inhalation injury, vitamin D deficiency was associated with longer LOS. In conclusion, patients with thermal injuries and vitamin D deficiency on admission have increased LOS and worsened clinical outcomes when compared with patients with nondeficient vitamin D concentrations.
Branding the Order of Texts and Bodies in Medieval South India
Authors: Peterson Jonathan 
Published: December 2023

Abstract
Branding is a popular mode of bodily marking among several Vaiṣṇava traditions in southern India. This article examines how a practice with no discernible basis in the Vedas was transformed into a marker of Vaidika piety and Brahman identity. I examine the first known Sanskrit treatise about devotional branding, a short essay titled Protective Amulet of Righteous Conduct (Saccaritrarakṣā) written by the influential Śrīvaiṣṇava scholar Vedānta Deśīka (c. 14th/15th CE). Like most of Vedānta Deśika’s writings, The Protective Amulet is an exemplar of high scholarship. But unlike many works of Sanskrit scholarship, the Protective Amulet seems to have bubbled up from a world of popular practice. This article is about the Vedicization of bodily branding and the process in which forms of reading and interpretation were used to transform new practices into allegedly timeless markers of identity and devotion. The close connection between branding as both a bodily and scholarly practice means that this article is also about the connection between words and flesh. Branding is, of course, material. It entails fire, metal, ash, sweat, skin, and scars. But branding is also semiotic and discursive, both in the many meanings grafted onto a single branded symbol as well as in the enormous volume of writing and debate that bodily branding provoked. A study of branding pushes us to think about texts and bodies as connected in ways that intellectual history and material studies have yet to fully acknowledge.
Site occupation and range expansion by the endangered, Mexican microendemic San Quintín Kangaroo Rat (Dipodomys gravipes)
Authors: Andrade-Sánchez Jorge , Mellink Eric , Riojas-López Mónica E , Tremor Scott , Vanderplank Sula E 
Published: December 2023

Abstract
The San Quintin Kangaroo Rat, a rodent species microendemic to the San Quintin–El Rosario region in Baja California that was considered potentially extinct in the wild, was recently rediscovered. This stimulated subsequent searches by us throughout its known distribution range and on sites that seemed suitable beyond its limits. We captured the species at 19 out of 42 localities surveyed, of which 6 are beyond its historically known distribution range, expanding the latter by ~60 km. Most sites occupied by the species occur on abandoned farmland in early ecological successional stages. Our data support that in the highly transformed agricultural landscape into which the region was converted in the 20th century, the species was able to survive undetected and colonize/recolonize sites once habitat became adequate after agricultural abandonment. This exhibits that the species is highly resilient and persisted as a metapopulation. Further research and conservation actions must be framed within context of the region’s agricultural development.
Types of administrative burden reduction strategies: who, what, and how
Authors: Benish Avishai , Tarshish Noam , Holler Roni , Gal John 
Published: December 2023

Abstract
This article contributes to the growing body of research on administrative burdens by providing a theoretically and empirically driven typology of governments’ burden reduction strategies. Despite the mounting interest in burden reduction, the literature still lacks a typology for systematically identifying and classifying such strategies. The article identifies three analytical dimensions of burden reduction: distributive (who bears the burden), intensiveness (what the level of burden is), and relational (how burden is experienced in bureaucratic encounters). Based on these dimensions, and drawing on a systematic analysis of the case of social security in Israel, we identify, define, and characterize seven distinct strategies of burden reduction: shifting, sharing, discarding, simplifying, expediting, communicating, and respecting. The article concludes with a discussion of these strategies, their applicability, practical implications, and directions for the research agenda on burden reduction.