bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health of children with chronic arthritis: Relationship of different measures and the quality of parent proxy reporting
Authors: Brunner Hermine I. , Klein‐Gitelman Marisa S. , Miller Michael J. , Trombley Michael , Baldwin Nicole , Kress Angela , Johnson Anne L. , Barron Andrea C. , Griffin Thomas A. , Passo Murray H. , Lovell Daniel J. 
Published: October 2004

AbstractObjectiveTo examine the strength of the association between different measures of health‐related quality of life (HRQOL), disability, pain, and well‐being in children with chronic arthritis. To evaluate whether HRQOL scores vary as a function of disability status beyond chance. To assess the quality of the parent proxy report for HRQOL as compared with disability, pain, and well‐being.MethodsMeasures of HRQOL (visual analog scale [VAS] of health, Pediatric Quality of Life Inventory [PedsQL], Juvenile Arthritis Quality of Life Questionnaire (JAQQ), and modified standard gamble technique [SG]), disability (Childhood Health Assessment Questionnaire), VAS of pain, and VAS of well‐being (VAS‐well) were completed by the parents (n = 119) and patients ≥8 years (SG: ≥12 years).ResultsHRQOL was highest when measured by the SG, whose utilities were no more than weakly correlated with any of the other outcomes. The values of all other HRQOL measures were at least moderately correlated with each other and with the VAS‐well. Irrespective of the measure used, disability was associated with significantly decreased HRQOL. There was fair to good agreement and moderate consistency of the HRQOL ratings (SG: fair consistency) between patients and parents with marked differences between health domains.ConclusionHRQOL measured by the PedsQL, JAQQ, and VAS are moderately to highly correlated with each other in children with chronic arthritis. The children's HRQOL significantly decreases with increasing disability. Despite more pronounced differences for some health domains, parents are moderate to good proxy reporters of HRQOL, disability, and well‐being of children with chronic arthritis.
Identification of modifiable work‐related factors that influence the risk of work disability in rheumatoid arthritis
Authors: Lacaille Diane , Sheps Samuel , Spinelli John J. , Chalmers Andrew , Esdaile John M. 
Published: October 2004

AbstractObjectiveTo define work‐related factors associated with increased risk of work disability (WD) in people with rheumatoid arthritis (RA).MethodsQuestionnaires were mailed to all RA patients who used a province‐wide arthritis treatment program between 1991 and 1998 (n = 1,824). The association between risk factors and WD (defined as no paid work due to RA for at least 6 months) was assessed using multiple logistic regression analysis, controlling for significant sociodemographic and disease‐related variables.ResultsOf the original 1,824 patients, 581 were eligible and responded to the questionnaire. Work survival analysis revealed a steady rate of WD starting early, with 7.5%, 18%, and 27% work disabled at 1, 5, and 10 years, respectively. Significant determinants in multiple logistic regression were physical function (Health Assessment Questionnaire), pain (visual analog scale), and 6 work‐related factors: self employment, workstation modification, work importance, family support toward employment, commuting difficulty, and comfort telling coworkers about RA.ConclusionWork disability occurs early in RA. Novel work‐related factors were identified, which are potentially modifiable, to help RA patients stay employed.
Psychosocial and geriatric correlates of functional status after total hip replacement
Authors: Bischoff‐Ferrari H. A. , Lingard E. A. , Losina E. , Baron J. A. , Roos E. M. , Phillips C. B. , Mahomed N. N. , Barrett J. , Katz J. N. 
Published: October 2004

AbstractObjectiveTo determine whether psychosocial factors, chronic diseases, and common geriatric problems are associated with poor physical function 3 years after primary total hip replacement (THR).MethodsWe studied a sample of Medicare recipients in Ohio, Pennsylvania, and Colorado (n = 922) who underwent primary THR in 1995 (mean ± SD age 73.1 ± 5.6 years, 32% men). Participants completed a questionnaire regarding lifestyle factors, medical history, and quality of life ∼3 years after the surgery. Physical function was measured using the function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index. We assessed the relationship between functional outcome 3 years postsurgery and 4 predictor domains: pain or complications in the operated hip, other musculoskeletal comorbidity, medical factors (obesity, chronic medical comorbidity, rheumatoid arthritis, and such common geriatric problems as falls, poor balance, or incontinence), and psychosocial factors (mental health, regular alcohol consumption, smoking, provider role, living alone, and education).ResultsTen percent of subjects had poor functional status. In a logistic regression model controlling for sex and age, the following factors were associated with an increased risk for poor functional status (in order of importance): pain in the back or lower extremity, severe pain in the operated hip, poor mental health, more than 1 common geriatric problem, obesity, and less than college education.ConclusionPain in the operated hip was strongly associated with poor functional status 3 years after THR. However, other factors associated with poor functional status were not related to the hip. Our results suggest that a comprehensive assessment of functional status in elderly THR patients should include assessment of common geriatric problems, mental health status, and weight.
Reliability and validity of the proposed American College of Rheumatology neuropsychological battery for systemic lupus erythematosus
Authors: Kozora Elizabeth , Ellison Misoo C. , West Sterling 
Published: October 2004

AbstractObjectiveTo examine the reliability and validity of the proposed American College of Rheumatology (ACR) neuropsychological battery for patients with systemic lupus erythematosus (SLE).MethodsThirty‐one SLE patients with a history of neuropsychiatric symptoms (NPSLE), 22 SLE patients without a history of neuropsychiatric symptoms (non‐NPSLE), and 25 healthy controls completed measures of cognition at baseline and after 1 month. The 1‐hour proposed ACR‐SLE battery was compared with a 4‐hour comprehensive battery (CB).ResultsSeven of 12 measures from the ACR‐SLE battery were lower in SLE patients compared with controls. Overall agreement between impairment on the ACR‐SLE battery and the CB was 90%. This was established using previously defined impairment on the CB and 4 of 12 scores impaired on the ACR‐SLE battery. Almost perfect agreement between the 2 batteries was found for non‐NPSLE patients and healthy controls (95–96%) and moderate agreement was reported for NPSLE patients (81%). Intraclass correlation coefficients for ACR‐SLE tests ranged from 0.40 to 0.90, indicating adequate reliability.ConclusionReliability and validity of the ACR‐SLE battery was established in this study. Agreement regarding classification for impairment was almost perfect for non‐NPSLE and moderate for the NPSLE patients. The ACR battery is well designed for general classification of cognitive impairment in SLE. However, comprehensive testing may be useful in identifying specific deficits in NPSLE.
Are there more than cross‐sectional relationships of social support and support networks with functional limitations and psychological distress in early rheumatoid arthritis? The European Research on Incapacitating Diseases and Social Support Longitudinal Study
Authors: Demange V. , Guillemin F. , Baumann M. , Suurmeijer T. P. B. M. , Moum T. , Doeglas D. , Briançon S. , van den Heuvel W. J. A. 
Published: October 2004

AbstractObjectiveTo investigate whether greater social support and support network are cross‐sectionally associated with less functional limitations and psychological distress in patients with early rheumatoid arthritis (RA); whether this association is constant over time; and whether increases in social support or support network are associated with less functional limitations and psychological distress.MethodsSubjects were from the European Research on Incapacitating Diseases and Social Support cohort and had early RA. Social support, support network, functional limitations (Health Assessment Questionnaire), and psychological distress (General Health Questionnaire) were assessed annually. Variance and covariance analyses with repeated measures were performed.ResultsA total of 542 subjects were assessed for 3 years. On average, patients with a greater amount of specific social support or a stronger specific support network experienced less functional limitation and less psychological distress. Changes in a given subject's functional limitations and psychological distress did not depend on his or her baseline social support or support network. Neither social support nor support network change over time.ConclusionThere may be a cross‐sectional link between specific social support or support network and functional limitations and psychological distress, but no longitudinal association could be evidenced.
Longitudinal comparison of the Health Assessment Questionnaire (HAQ) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Authors: Bruce Bonnie , Fries James 
Published: October 2004

AbstractObjectiveTo compare the measurement properties of the generic Health Assessment Questionnaire (HAQ) and the disease‐specific Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).MethodsPhysical function, pain, and radiographic progression were assessed in knee or hip osteoarthritis patients (n = 271) who had 2 radiographs that were at least 6 months apart from 6 ARAMIS (Arthritis, Rheumatism, and Aging Medical Information System) databanks. Data were compared at baseline and after a mean of 3.2 (SE 0.10) years. Correlation coefficients and standardized effect sizes (SES) were used to assess their relationship and responsiveness.ResultsThe majority of items in the 2 function and pain scales overlapped and were highly and significantly correlated with each other at baseline and last assessments (function at baseline rs = 0.71 and function at last assessment rs = 0.79, P < 0.0001; pain at baseline rs = 0.70 and pain at last assessment rs = 0.76, P < 0.0001). The HAQ disability index and total knee score were more sensitive to detection of disease progression than the WOMAC (SES for HAQ = 0.27; SES for WOMAC = −0.05).ConclusionBoth instruments showed favorable measurement properties, with the HAQ having the advantages of being more sensitive to change and adaptable to a wide variety of diseases and conditions, which contribute to the generalizability of findings.
Serum levels of matrix metalloproteinase 3 and macrophage colony‐stimulating factor 1 correlate with disease activity in ankylosing spondylitis
Authors: Yang Chunhua , Gu Jieruo , Rihl Markus , Baeten Dominique , Huang Feng , Zhao Miansong , Zhang Hanwei , Maksymowych Walter P. , De Keyser Filip , Veys Eric M. , Yu David T. Y. 
Published: October 2004

AbstractObjectiveTo assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP‐3) and macrophage colony‐stimulating factor (M‐CSF) in patients with ankylosing spondylitis (AS).MethodsSerum levels of MMP‐3 and M‐CSF were measured in AS patients who did and did not receive infliximab treatment. These were compared with those of 28 healthy subjects.ResultsIn the group of AS patients not treated with biologics, both M‐CSF and MMP‐3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other. Logistic regression analysis showed that MMP‐3 values were high in those with severely active disease. Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP‐3, but no change in the serum M‐CSF values.ConclusionMMP‐3 and M‐CSF are potentially useful markers of AS disease activity.
Randomized, double‐blind, placebo‐controlled glucosamine discontinuation trial in knee osteoarthritis
Authors: Cibere Jolanda , Kopec Jacek A. , Thorne Anona , Singer Joel , Canvin Janice , Robinson David B. , Pope Janet , Hong Paul , Grant Eric , Esdaile John M. 
Published: October 2004

AbstractObjectiveTo assess the efficacy of glucosamine sulfate in knee osteoarthritis (OA).MethodsA 4‐center, 6‐month, randomized, double‐blind, placebo‐controlled glucosamine discontinuation trial was conducted in 137 current users of glucosamine with knee OA who had experienced at least moderate improvement in knee pain after starting glucosamine. Study medication dosage was equivalent to the dosage of glucosamine taken prior to the study (maximum 1,500 mg/day). Followup continued for 6 months or until disease flare, whichever occurred first. The primary outcome was the proportion of disease flares in the glucosamine and placebo groups using an intent‐to‐treat analysis. Secondary outcomes included time to disease flare; analgesic medication use; severity of disease flare; and change in pain, stiffness, function and quality of life in the glucosamine and placebo groups.ResultsDisease flare was seen in 28 (42%) of 66 placebo patients and 32 (45%) of 71 glucosamine patients (difference −3%; 95% confidence interval [95% CI] −19, 14; P = 0.76). In the Cox regression analysis, after adjustment for sex, study site, and OA radiographic severity, time to disease flare was not significantly different in the glucosamine compared with placebo group (hazard ratio of flare = 0.8; 95% CI 0.5, 1.4; P = 0.45). At final study visit, acetaminophen was used in 27% and 21% of placebo and glucosamine patients, respectively (P = 0.40), nonsteroidal antiinflammatory drugs were used in 29% and 30% (P = 0.92), and both were used in 20% and 21% (P = 0.84). No differences were found in severity of disease flare or other secondary outcomes between placebo and glucosamine patients.ConclusionIn patients with knee OA with at least moderate subjective improvement with prior glucosamine use, this study provides no evidence of symptomatic benefit from continued use of glucosamine sulfate.
A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: A meta‐analysis
Authors: Lee Chin , Straus Walter L. , Balshaw Robert , Barlas Suna , Vogel Suzanne , Schnitzer Thomas J. 
Published: October 2004

AbstractObjectiveTo perform a meta‐analysis comparing the efficacy and safety of recommended dosages of nonsteroidal antiinflammatory drugs (NSAIDs), including cyclooxygenase 2 inhibitors, versus acetaminophen in the treatment of symptomatic hip and knee osteoarthritis.MethodsMedline and EMBASE searches were performed for original clinical trials directly comparing NSAIDs with acetaminophen. A standardized form was used to abstract all data, including outcome measures of pain at rest, walking pain, and dropouts due to adverse effects. Inverse‐variance‐weighted mean differences (WMDs) and 95% confidence intervals (95% CI) for pain measures were determined for treatment groups. Odds ratios (ORs) and 95% CIs were calculated for withdrawals due to adverse events. Results were compared using a random effects model.ResultsSeven articles met inclusion criteria with sufficient data for analysis. Participants had a mean age of 61.1 years and 71.1% were women. Test of heterogeneity was not significant for either rest (P = 0.73) or walking (P = 0.76) pain. The scores for overall pain at rest (WMD −6.33 mm on a 100‐mm visual analog scale [VAS], 95% CI −9.24, −3.41) and walking pain (WMD –5.76 mm on a 100‐mm VAS, 95% CI –8.99, –2.52) favored the NSAID‐treated group. Although NSAIDs elevated the risk of withdrawals due to adverse events, the difference was not statistically significant (OR 1.45, 95% CI 0.93, 2.27).ConclusionNSAIDs are statistically superior in reducing rest and walking pain compared with acetaminophen for symptomatic osteoarthritis. Safety, measured by discontinuation due to adverse events, was not statistically different between NSAID‐ and acetaminophen‐treated groups.
A crossover trial of custom‐made and commercially available wrist splints in adults with inflammatory arthritis
Authors: Haskett Sandra , Backman Catherine , Porter Barbara , Goyert Jill , Palejko Gillian 
Published: October 2004

AbstractObjectiveTo compare the effect of 3 wrist splints (2 prefabricated commercial splints and 1 custom made) on perceived wrist pain, hand function, and perceived upper extremity function in adults with inflammatory arthritis.MethodsSubjects (n = 45, mean age 49 years, mean disease duration 8.6 years) were randomly assigned to treatment order in a 3‐phase crossover trial. Splints were worn for 4 weeks, separated by 1‐week washouts. Outcomes were assessed at baseline, after each splint phase and washout period, and at 6 months' followup using a pain visual analog scale (VAS), the Arthritis Hand Function Test, and McMaster‐Toronto Arthritis Patient Function Preference questionnaire. Data were analyzed with multivariate analyses of variance (MANOVAs), t‐tests, and chi‐square tests.ResultsThere did not appear to be order or carryover effects. MANOVA indicated that wrist splints significantly reduced pain (P = 0.007). The custom leather splint was most effective in reducing pain, from 4.1 cm to 2.8 cm on the VAS (P = 0.001). All splints improved hand strength, and the commercial Rolyan splint provided significantly stronger grip than the Anatech commercial splint (P = 0.04). In contrast to previous studies, splints did not compromise dexterity. There were several significant differences among splints, depending on the outcome measure. Improvements were maintained at 6 months.ConclusionAfter 4 weeks' use, wrist splints reduce pain, improve strength, and do not compromise dexterity. Similar improvements were achieved with the custom leather splint and Rolyan commercial splint, which were superior to the Anatech commercial splint.
Utilization of low‐volume hospitals for total hip replacement
Authors: Losina Elena , Barrett Jane , Baron John A. , Levy Matthew , Phillips Charlotte B. , Katz Jeffrey N. 
Published: October 2004

AbstractObjectiveTo identify factors associated with utilization of low‐volume hospitals for total hip replacement (THR) and to estimate differences in the distances that Medicare beneficiaries had to travel to reach low‐ or high‐volume hospitals.MethodsWe studied a population‐based sample of 1,146 Medicare beneficiaries who underwent elective THR in 1995. Using multiple data sources including medical record review, Medicare claims data, 1990 Census data, and a patient survey, we examined factors independently associated with utilization of low‐volume hospitals for elective THR. We estimated the magnitude of difference in distances for patients undergoing THR in low‐ and high‐volume hospitals. We determined the distance between each patient's residence and the treating hospital using MapQuest.ResultsRural residency, low income, and low educational attainment, as well as belief in the importance of convenient location in the choice of hospital, were associated with higher utilization of low‐volume hospitals. Rural and suburban patients who went to low‐volume hospitals traveled much less than patients operated upon in high‐volume centers.ConclusionPolicies aimed at restricting THR to high‐volume centers would differentially affect poor, less educated, and rural patients. Voluntary efforts to shift THR to high‐volume centers should involve educating these patients and their referring physicians about differences in both short‐term and longer‐term outcomes between high‐ and low‐volume centers.
Reliability and validity of the Duruöz Hand Index in persons with systemic sclerosis (scleroderma)
Authors: Brower Lisa M. , Poole Janet L. 
Published: October 2004

AbstractObjectiveTo examine the test–retest reliability and concurrent validity of the Duruöz Hand Index (DHI) in persons with scleroderma.MethodsForty patients with scleroderma and no other major medical problems completed the DHI at 2 points in time to assess test–retest reliability. To assess validity, participants were administered the Arthritis Hand Function Test (AHFT), the Hand Mobility in Scleroderma Test (HAMIS), and the Keital Function Test (KFT), all performance‐based tests. In addition, participants completed the Health Assessment Questionnaire (HAQ), a self report of functional ability.ResultsTest–retest reliability intraclass correlation coefficients for the DHI ranged from 0.81 to 0.97. Scores on the DHI did not correlate with HAMIS scores, but were significantly correlated with scores from the KFT (rs = 0.48, P < 0.01), HAQ (rs = 0.79, P < 0.01), and all sections of the AHFT (rs = 0.34–0.60, P < 0.05–0.01).ConclusionThe results from this study show the DHI to be a reliable and valid test for persons with scleroderma.
Anti–tumor necrosis factor agents for rheumatoid arthritis in the setting of chronic hepatitis C infection
Authors: Parke Frank A. , Reveille John D. 
Published: October 2004

AbstractObjectiveTo examine the safety of using anti–tumor necrosis factor (TNF) therapy in patients with rheumatoid arthritis (RA) in the setting of hepatitis C virus (HCV) infection.MethodsThe charts of 5 patients known to have RA requiring anti‐TNF therapy as well as established HCV infection were reviewed retrospectively for laboratory data of hepatic parenchymal inflammation and viral proliferation while taking these agents.ResultsIn a mean ± SD followup period of 41 months (± 28.2 months), no patient displayed evidence of sustained elevation of serum aminotransferases during therapy with anti‐TNF. Additionally, 1 patient was observed to have a decreased HCV viral load after extended treatment with only anti‐TNF (no therapy for HCV).ConclusionAnti‐TNF therapy for RA in the setting of HCV appears to be safe and well tolerated without apparent influence on the underlying HCV infection. Therefore, this approach should be further evaluated prospectively for longterm safety.
Measuring the consequences of osteoarthritis and joint pain in population‐based studies: Can existing health measurement instruments capture levels of participation?
Authors: Wilkie R. , Peat G. , Thomas E. , Croft P. R. 
Published: October 2004

AbstractObjectiveTo identify health measurement instruments to investigate levels of participation associated with joint pain in a population survey questionnaire.MethodA comprehensive electronic search of the published literature was performed to identify potential instruments that could measure participation. All items from identified instruments were assessed for the ability to measure participation by 2 experienced and 2 inexperienced assessors. Agreement was determined in terms of actual agreement (%) and agreement beyond chance (κ).ResultsTwenty‐seven instruments (912 items) were identified. Agreement between the experienced assessors occurred in 86% of items (κ = 0.70, 95% confidence interval [95% CI] 0.65–0.75) and between the inexperienced assessors in 72% (κ = 0.40, 95% CI 0.34–0.46). The greatest proportion of participation items in one instrument was 82%.ConclusionNone of the identified instruments consisted entirely of participation items. The concept of participation and its translation into measurement for use in the general population is likely to need further development.