bluuebunny/crossref_metadata_2025_split huggingface dataset:
“World”-Traveling in Tule Canoes: Indigenous Philosophies of Language and an Ethic of Incommensurability
Authors: Meissner Shelbi Nahwilet 
Published: December 2023

AbstractIndigenous language activists talk about incommensurability all the time—in interesting ways that link language and knowledge as components of Indigenous lifeways that can't be disentangled. According to many of these scholar-activists, what is untranslatable about Indigenous languages is often what is incommensurate about Indigenous worlds. Drawing upon resources from Indigenous language-reclamation work, I outline here a nonexhaustive taxonomy of incommensurability in the literature about Indigenous philosophy of language, and gesture at the ways coalitional relationships might be built that hold space for these different varieties of incommensurability. For ease of explication and to honor Indigenous ways of knowing, I employ here an organizational metaphor rooted in my own communities’ traditions of canoe-voyaging to organize three forms of incommensurability that emerge from Indigenous philosophies of language:impassable incommensurabilityandstrategic impassable incommensurability(big water through a rock garden), as well asincommensurability with technical passage:(heavy water through a rock garden). These forms of incommensurability, as they spring from Indigenous philosophies of language, lend themselves toward nuanced insights for careful and considerate world-traveling (à la Lugones) that holds space for epistemic and linguistic sovereignty.
Wives’ Work: Gender and Status in a List from the Mishnah
Authors: Gopalakrishnan Pratima 
Published: December 2023

AbstractA curious list from the Mishnah lists seven labors that a woman does for her husband. The juxtaposition of these seven tasks in a list creates a hierarchy among them, which dictates the order in which the performance of a task is transferred to an enslaved woman as the size of the woman’s dowry increases. Scholars read this text to understand how wealth shapes a woman’s labor obligations, but they have taken the form and contents of the list as a given. This article argues that the list establishes the category of wives’ work in rabbinic literature and defines it as work that is performed interchangeably by the wife or enslaved women. The form of the list can be compared to other lists within the Mishnah as well as lists of housework in contemporary traditions. These comparisons allow for a more critical stance toward the interplay of slavery and status in the Mishnah. The Mishnah’s framing of a wife’s work as interchangeable belies how the individual tasks were embedded in broader social, economic, and technological transformations.
Multi‐Instrumental Observation of an Upward Cloud‐To‐Air Discharge Above a Mediterranean Storm
Authors: Hausknost Gabriel , Ventre Axel , Soula Serge , Coquillat Sylvain , Mlynarczyk Janusz , Hermant Alex 
Published: December 2023

AbstractOn the night of 1 November 2022, a luminous discharge was produced above a storm over the northwestern Mediterranean Sea. An unprecedented set of optical and electrical data makes it possible to characterize this event. It is embedded in a lightning flash which starts with a positive discharge producing a high‐power very high frequency (VHF) source at 6 km followed by VHF sources at 10 and 4 km within the cloud. The luminous event above the cloud is identified as a negative leader emerging from the cloud and reaching 14.2 km, topped with streamers up to about 17.2 km, and followed by channel rebrightening phases connected to the negative charge of a positive dipole. It is preceded by a convective surge and a production of positive flashes within the same storm region. Its polarity and its triggering conditions show similarities with those of gigantic jets.
Real-world prevalence of homologous recombination repair mutations in advanced prostate cancer: an analysis of two clinico-genomic databases
Authors: Shui Irene M. , Burcu Mehmet , Shao Changxia , Chen Cai , Liao Chi-Yin , Jiang Shan , Cristescu Razvan , Parikh Ravi B. 
Published: December 2023

Abstract
Background
Homologous recombination repair mutation (HRRm) status may guide risk-stratification and treatment decisions, including polyadenosine diphosphate–ribose polymerase inhibitor use, in advanced prostate cancer. Although HRRm prevalence has been reported in single-institution studies or clinical trials, real-world HRRm prevalence in diverse populations is unknown. We describe HRRm in the clinical setting using two real-world clinicogenomic databases: the Flatiron Health and Foundation Medicine, Inc. Clinico-Genomic Database (CGDB), a national electronic health record-derived database, and the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (GENIE).

Methods
This cross-sectional analysis included 3757 individuals diagnosed with prostate cancer who had next generation sequencing (NGS) as standard of care. The CGDB included men with advanced/metastatic prostate cancer and genetic data included both germline and somatic pathogenic mutations. The GENIE analysis included men with prostate cancer whose received NGS as standard of care, but the data were filtered to include somatic mutations only. Due to key differences among databases, direct comparisons were not possible. Overall prevalence of HRRm was calculated and stratified by demographic and clinical characteristics.

Results
HRRm prevalence (combined germline and somatic) in CGDB (n = 487) was 24.6% (95% CI 20.9–28.7%), with no major differences across demographic and disease characteristic subgroups. HRRm prevalence (somatic) in GENIE (n = 3270) was 11.0% (95% CI 10.0–12.1%), which varied between 9.5% and 18.4% across treatment centers.

Conclusions
Approximately one-quarter of patients with advanced/metastatic prostate cancer in the CGDB had germline and/or somatic HRRm, which is consistent with clinical trials such as the PROfound study that used a similar NGS platform and algorithm to define HRRm. In the GENIE database, HRRm prevalence varied by treatment center or NGS platform. More research is needed to understand real-world HRRm prevalence variations.
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
Authors: Zakkak N. , Barclay M. E. , Swann R. , McPhail S. , Rubin G. , Abel G. A. , Lyratzopoulos G. 
Published: December 2023

Abstract
Background
Understanding relationships between presenting symptoms and subsequently diagnosed cancers can inform symptom awareness campaigns and investigation strategies.

Methods
We used English National Cancer Diagnosis Audit 2018 data for 55,122 newly diagnosed patients, and examined the relative frequency of presenting symptoms by cancer site, and of cancer sites by presenting symptom.

Results
Among 38 cancer sites (16 cancer groups), three classes were apparent: cancers with a dominant single presenting symptom (e.g. melanoma); cancers with diverse presenting symptoms (e.g. pancreatic); and cancers that are often asymptomatically detected (e.g. chronic lymphocytic leukaemia). Among 83 symptoms (13 symptom groups), two classes were apparent: symptoms chiefly relating to cancers of the same body system (e.g. certain respiratory symptoms mostly relating to respiratory cancers); and symptoms with a diverse cancer site case-mix (e.g. fatigue). The cancer site case-mix of certain symptoms varied by sex.

Conclusion
We detailed associations between presenting symptoms and cancer sites in a large, representative population-based sample of cancer patients. The findings can guide choice of symptoms for inclusion in awareness campaigns, and diagnostic investigation strategies post-presentation when cancer is suspected. They can inform the updating of clinical practice recommendations for specialist referral encompassing a broader range of cancer sites per symptom.
Deliberately making miskates: Behavioural consistency under win maximization and loss maximization conditions
Authors: Zhang Yajing , Huynh Thi Kim Truc , Dyson Benjamin James 
Published: December 2023

AbstractWe argue that the feedback traditionally used to indicate negative outcomes causes future detrimental performance because of the default goal of win maximization. In gaming paradigms where participants intentionally performed as well (win maximization) and as poorly (loss maximization) as possible, we showed a double dissociation where actions following wins were more consistent during win maximization, but actions following losses were more consistent during loss maximization. This broader distinction between goal-congruent and goal-incongruent feedback suggests that individuals are able to flexibly redefine their definition of ‘success’, and provide a reconsideration of the way we think about ‘losing’.
Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution
Authors: Xie Hao , Han Xiaofei , Xiao Guihua , Xu Hanyun , Zhang Yuanlong , Zhang Guoxun , Li Qingwei , He Jing , Zhu Dan , Yu Xinguang , Dai Qionghai 
Published: December 2023

AbstractFluorescence microscopy allows for the high-throughput imaging of cellular activity across brain areas in mammals. However, capturing rapid cellular dynamics across the curved cortical surface is challenging, owing to trade-offs in image resolution, speed, field of view and depth of field. Here we report a technique for wide-field fluorescence imaging that leverages selective illumination and the integration of focal areas at different depths via a spinning disc with varying thickness to enable video-rate imaging of previously reconstructed centimetre-scale arbitrarily shaped surfaces at micrometre-scale resolution and at a depth of field of millimetres. By implementing the technique in a microscope capable of acquiring images at 1.68 billion pixels per second and resolving 16.8 billion voxels per second, we recorded neural activities and the trajectories of neutrophils in real time on curved cortical surfaces in live mice. The technique can be integrated into many microscopes and macroscopes, in both reflective and fluorescence modes, for the study of multiscale cellular interactions on arbitrarily shaped surfaces.
Single-molecule electron spin resonance by means of atomic force microscopy
Authors: Sellies Lisanne , Spachtholz Raffael , Bleher Sonja , Eckrich Jakob , Scheuerer Philipp , Repp Jascha 
Published: December 2023

AbstractUnderstanding and controlling decoherence in open quantum systems is of fundamental interest in science, whereas achieving long coherence times is critical for quantum information processing1. Although great progress was made for individual systems, and electron spin resonance (ESR) of single spins with nanoscale resolution has been demonstrated2–4, the understanding of decoherence in many complex solid-state quantum systems requires ultimately controlling the environment down to atomic scales, as potentially enabled by scanning probe microscopy with its atomic and molecular characterization and manipulation capabilities. Consequently, the recent implementation of ESR in scanning tunnelling microscopy5–8 represents a milestone towards this goal and was quickly followed by the demonstration of coherent oscillations9,10 and access to nuclear spins11 with real-space atomic resolution. Atomic manipulation even fuelled the ambition to realize the first artificial atomic-scale quantum devices12. However, the current-based sensing inherent to this method limits coherence times12,13. Here we demonstrate pump–probe ESR atomic force microscopy (AFM) detection of electron spin transitions between non-equilibrium triplet states of individual pentacene molecules. Spectra of these transitions exhibit sub-nanoelectronvolt spectral resolution, allowing local discrimination of molecules that only differ in their isotopic configuration. Furthermore, the electron spins can be coherently manipulated over tens of microseconds. We anticipate that single-molecule ESR-AFM can be combined with atomic manipulation and characterization and thereby paves the way to learn about the atomistic origins of decoherence in atomically well-defined quantum elements and for fundamental quantum-sensing experiments.
TAF15 amyloid filaments in frontotemporal lobar degeneration
Authors: Tetter Stephan , Arseni Diana , Murzin Alexey G. , Buhidma Yazead , Peak-Chew Sew Y. , Garringer Holly J. , Newell Kathy L. , Vidal Ruben , Apostolova Liana G. , Lashley Tammaryn , Ghetti Bernardino , Ryskeldi-Falcon Benjamin 
Published: December 2023

AbstractFrontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer’s disease, and is often also associated with motor disorders1. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins2. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes3,4. The presence of amyloid filaments and their identities and structures in the remaining approximately 10% of FTLD cases are unknown but are widely believed to be composed of the protein fused in sarcoma (FUS, also known as translocated in liposarcoma). As such, these cases are commonly referred to as FTLD–FUS. Here we used cryogenic electron microscopy (cryo-EM) to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with FTLD–FUS. Surprisingly, we found abundant amyloid filaments of the FUS homologue TATA-binding protein-associated factor 15 (TAF15, also known as TATA-binding protein-associated factor 2N) rather than of FUS itself. The filament fold is formed from residues 7–99 in the low-complexity domain (LCD) of TAF15 and was identical between individuals. Furthermore, we found TAF15 filaments with the same fold in the motor cortex and brainstem of two of the individuals, both showing upper and lower motor neuron pathology. The formation of TAF15 amyloid filaments with a characteristic fold in FTLD establishes TAF15 proteinopathy in neurodegenerative disease. The structure of TAF15 amyloid filaments provides a basis for the development of model systems of neurodegenerative disease, as well as for the design of diagnostic and therapeutic tools targeting TAF15 proteinopathy.
Direct purification and immobilization of his-tagged enzymes using unmodified nickel ferrite NiFe2O4 magnetic nanoparticles
Authors: Lau Elizabeth C. H. T. , Dodds Kimberley C. , McKenna Catherine , Cowan Rhona M. , Ganin Alexey Y. , Campopiano Dominic J. , Yiu Humphrey H. P. 
Published: December 2023

AbstractPurification of valuable engineered proteins and enzymes can be laborious, costly, and generating large amount of chemical waste. Whilst enzyme immobilization can enhance recycling and reuse of enzymes, conventional methods for immobilizing engineered enzymes from purified samples are also inefficient with multiple-step protocols, regarding both the carrier preparation and enzyme binding. Nickel ferrite magnetic nanoparticles (NiFe2O4 MNPs) offer distinct advantages in both purification and immobilization of enzymes. In this work, we demonstrate the preparation of NiFe2O4 MNPs via a one-step solvothermal synthesis and their use in direct enzyme binding from cell lysates. These NiFe2O4 MNPs have showed an average diameter of 8.9 ± 1.7 nm from TEM analysis and a magnetization at saturation (Ms) value of 53.0 emu g–1 from SQUID measurement. The nickel binding sites of the MNP surface allow direct binding of three his-tagged enzymes, d-phenylglycine aminotransferase (d-PhgAT), Halomonas elongata ω-transaminase (HeωT), and glucose dehydrogenase from Bacillus subtilis (BsGDH). It was found that the enzymatic activities of all immobilized samples directly prepared from cell lysates were comparable to those prepared from the conventional immobilization method using purified enzymes. Remarkably, d-PhgAT supported on NiFe2O4 MNPs also showed similar activity to the purified free enzyme. By comparing on both carrier preparation and enzyme immobilization protocols, use of NiFe2O4 MNPs for direct enzyme immobilization from cell lysate can significantly reduce the number of steps, time, and use of chemicals. Therefore, NiFe2O4 MNPs can offer considerable advantages for use in both enzyme immobilization and protein purification in pharmaceutical and other chemical industries.
Microbial and potentially toxic elements risk assessment in high Andean river water based on Monte Carlo simulation, Peru
Authors: Custodio María , Peñaloza Richard , Ochoa Salomé , De la Cruz Heidi , Rodríguez Ciro , Cuadrado Walter 
Published: December 2023

AbstractThe study evaluated microbial and Potentially Toxic Elements—PTEs risks in high Andean river water in Peru using Monte Carlo simulation. A total of 144 water samples were collected from four rivers and evaluated for physicochemical parameters, PTEs and bacterial pathogens. The microbial risk analysis for exposure to pathogens present in the water was based on the probability of occurrence of diseases associated withEscherichia coli,Pseudomonas aeruginosaand enterococci. PTEs risk analysis was performed using a Monte Carlo simulation approach. The results showed that the highest microbial risk due to exposure to water contaminated byE. coli,P. aeruginosaand enterococci was recorded in the Miraflores and Chia rivers. Meanwhile, the analysis of carcinogenic and non-carcinogenic risk by PTEs in adults and children revealed that the Chia river presents a high risk of contamination by PTEs, especially the carcinogenic risk for children. The Monte Carlo simulation indicated a 56.16% and 94.85% probability of exceeding the limit value of 0.0001 for carcinogenic risk in adults and children, respectively. It can be concluded that children consuming the waters of the Chia river are potentially at risk of As toxicity.
Tracing the Iceland plume and North East Atlantic breakup in the lithosphere
Authors: Gómez Dacal María Laura , Scheck-Wenderoth Magdalena , Faleide Jan Inge , Abdelmalak Mohamed Mansour , Bott Judith , Anikiev Denis 
Published: December 2023

AbstractPlumes are domains where hotter material rises through Earth´s mantle, heating also the moving lithospheric plates that may experience thinning or even continental breakup. In particular, the Iceland plume in the NE Atlantic (NEA) could have been instrumental in facilitating the breakup between Europe and Laurentia in the earliest Eocene. Here we present an open access three-dimensional density model of the NEA crust and uppermost mantle that is consistent with previously un-integrated available data. We propose that high-density anomalies in the crust represent the preserved modifications of the lithosphere in consequence of the plate’s journey over the hot mantle plume. Besides, low-density anomalies in the uppermost mantle would represent the present-day effect of the mantle plume and its interaction with the mid-ocean ridges. Overall, the model indicates that the presence of the plume together with the pre-existing crustal configuration controlled the timing, mechanisms and localization of the NEA breakup.
Impact of radial interplanetary magnetic fields on the inner coma of comet 67P/Churyumov-Gerasimenko
Authors: Gunell Herbert , Goetz Charlotte , Fatemi Shahab 
Published: December 2023

Context. The direction of the interplanetary magnetic field determines the nature of the interaction between a Solar System object and the solar wind. For comets, it affects the formation of both a bow shock and other plasma boundaries, as well as mass-loading. Around the nucleus of a comet, there is a diamagnetic cavity, where the magnetic field is negligible. Observations by the Rosetta spacecraft have shown that, most of the time, the diamagnetic cavity is located within a solar-wind ion cavity, which is devoid of solar wind ions. However, solar wind ions have been observed inside the diamagnetic cavity on several occasions. Understanding what determines whether or not the solar wind can reach the diamagnetic cavity also advances our understanding of comet–solar wind interaction in general.
Aims. We aim to determine the influence of an interplanetary magnetic field directed radially out from the Sun – that is, parallel to the solar wind velocity – on the comet–solar wind interaction. In particular, we explore the possibility of solar wind protons entering the diamagnetic cavity under radial field conditions.
Methods. We performed global hybrid simulations of comet 67P/Churyumov-Gerasimenko using the simulation code Amitis for two different interplanetary magnetic field configurations and compared the results to observations made by the Rosetta spacecraft.
Results. We find that, when the magnetic field is parallel to the solar wind velocity, no bow shock forms and the solar wind ions are able to enter the diamagnetic cavity. A solar wind ion wake still forms further downstream in this case.
Conclusions. The solar wind can enter the diamagnetic cavity if the interplanetary magnetic field is directed radially from the Sun, and this is in agreement with observations made by instruments on board the Rosetta spacecraft.
SEAWINES: Use of macroalgae as biostimulants against fungal diseases in grapevines
Authors: Zarraonaindia Iratxe , Cantos-Villar Emma , Diez Ana , Mena-Petite Amaia , Perez-Alvarez Eva , Cretazzo Enrico , Pébarthé-Courrouilh Anthony , Bertazzon Nadia , Lacuesta Maite , Puertas Belén , Perez-Lopez Usue , Cluzet Stéphanie , Hachero-Cruzado Ismael , José Córdoba-Granados Juan 
Published: December 2023

The outlook for climate change foresees major impacts on vineyards worldwide, shifting pathogens distribution and dynamics demanding more intense plant protection measures in certain regions, increasing viticulture's dependence on phytochemicals and pesticides. However, the European Commission is applying restrictions on their use, encouraging the development of more sustainable strategies efficient for disease control. Seaweeds represent an ecological alternative for a more sustainable production. Previous studies have shown that algae extracts contain compounds capable of reducing the abundance of plant fungal pathogens. Despite it, little is known about the molecular mechanism underlying this response.
SEAWINES project is evaluating the efficacy of the foliar application of Ulva ohnoi and Rugulopteryx okamurae extracts to control powdery and downy mildew, in addition to testing their effect on grape and wine quality. To our knowledge, this is the first study evaluating R. okamurae biostimulant capacity and fungicidal effect in viticulture. This macroalgae is relevant since it is an invasive species in our coasts, causing incalculable economic and environmental burdens. We aim to 1- Reduce the usage of chemicals in grapevines; 2- Reduce fungal diseases in viticulture; 3- Valorize polysaccharides from seaweeds; 4- Increase the added-value to wines (ecological and quality); and 5- Provide an alternative use to seaweed biomass, contributing to bio-circular economy and reducing its accumulation in our coasts.
Das Lernkonzept „ViGaTu – Virtueller Gastrotutor“
Authors: Engelke Monika , Hann Alexander , Henniger Dorothea , Meining Alexander , Seufert Tina , Riemer Valentin , Ropinski Timo , Kreiser Julian 
Published: December 2023

ZusammenfassungDas Projekt ViGaTu (Virtueller Gastrotutor) umfasst das Erlernen der leitliniengerechten Vorsorgekoloskopie für Pflegende, Ärzt*innen in der gastroenterologischen Endoskopie mittels Virtual Reality in einem geschütztem Lernraum und unabhängig vom Arbeitssetting (Klinik oder Praxis), in dem der Trainee ausgebildet wird. Dazu wird eine Lernsoftware auf einem Head-Mounted-Display (Oculus Quest 2) genutzt. Erste Umfragen zur Handhabbarkeit und Anwenderfreundlichkeit ergaben ein sehr positives Feedback.