bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time, momentum, and energy resolved pump-probe tunneling spectroscopy of two-dimensional electron systems
Authors: Yoo H. M. , Korkusinski M. , Miravet D. , Baldwin K. W. , West K. , Pfeiffer L. , Hawrylak P. , Ashoori R. C. 
Published: November 2023

AbstractReal-time probing of electrons can uncover intricate relaxation mechanisms and many-body interactions in strongly correlated materials. Here, we introduce time, momentum, and energy resolved pump-probe tunneling spectroscopy (Tr-MERTS). The method allows the injection of electrons at a particular energy and observation of their subsequent decay in energy-momentum space. Using Tr-MERTS, we visualize electronic decay processes, with lifetimes from tens of nanoseconds to tens of microseconds, in Landau levels formed in a GaAs quantum well. Although most observed features agree with simple energy-relaxation, we discovered a splitting in the nonequilibrium energy spectrum in the vicinity of a ferromagnetic state. An exact diagonalization study suggests that the splitting arises from a maximally spin-polarized state with higher energy than a conventional equilibrium skyrmion. Furthermore, we observe time-dependent relaxation of the splitting, which we attribute to single-flipped spins forming skyrmions. These results establish Tr-MERTS as a powerful tool for studying the properties of a 2DES beyond equilibrium.
The seafloor from a trait perspective. A comprehensive life history dataset of soft sediment macrozoobenthos
Authors: Meijer Kasper J. , Gusmao Joao Bosco , Bruil Lisa , Franken Oscar , Grimm Ise A. , van der Heide Tjisse , Hijner Nadia , Holthuijsen Sander J. , Hübner Lisa , Thieltges David W. , Olff Han , Eriksson Britas Klemens , Govers Laura L. 
Published: November 2023

AbstractBiological trait analysis (BTA) is a valuable tool for evaluating changes in community diversity and its link to ecosystem processes as well as environmental and anthropogenic perturbations. Trait-based analytical techniques like BTA rely on standardised datasets of species traits. However, there are currently only a limited number of datasets available for marine macrobenthos that contain trait data across multiple taxonomic groups. Here, we present an open-access dataset of 16 traits for 235 macrozoobenthic species recorded throughout multiple sampling campaigns of the Dutch Wadden Sea; a dynamic soft bottom system where humans have long played a substantial role in shaping the coastal environment. The trait categories included in this dataset cover a variety of life history strategies that are tightly linked to ecosystem functioning and the resilience of communities to (anthropogenic) perturbations and can advance our understanding of environmental changes and human impacts on the functioning of soft bottom systems.
Clinical efficacy of electroacupuncture-like magnetic therapy compared to conventional transcutaneous electrical nerve stimulation in individuals with carpal tunnel syndrome
Authors: Lo Sui-Foon , Chou Li-Wei , Chung Huynh , Lin Hsiu-Chen 
Published: November 2023

AbstractThis study aimed to evaluate the clinical efficacy of an electroacupuncture-like magnetic therapy (ELMT) and conventional transcutaneous electrical nerve stimulation (TENS) in patients with carpal tunnel syndrome (CTS). A prospective randomized controlled trial in single-centre was conducted. Thirty-four CTS patients confirmed by electrodiagnostic study were randomized into TENS or ELMT group and completed a six-week treatment program. TENS or ELMT treatment was applied on acupuncture point PC-6 (Neiguan) and one selected hand acupoint. Therapeutic exercises were also included after the electrophysical modality. Their physical signs, motor and sensory performances, Boston Carpal Tunnel Questionnaire (BCTQ) scores, and results of electrodiagnostic study were evaluated. After treatments, both groups demonstrated significantly decreased BCTQ scores and positive rate of Tinel’s sign in the major symptomatic side, which indicated improvements in the symptom severity and physical functions. Significant increases in distal sensory amplitude and nerve conduction velocity of the median nerve were only found in the ELMT group. Our study found either conventional TENS or ELMT plus therapeutic exercises could improve the symptomatology and physical provocation sign of CTS. The ELMT has additional improvement in the nerve conduction in patients with CTS.
Interactions between functional networks in Parkinson's disease mild cognitive impairment
Authors: Delgado-Alvarado Manuel , Ferrer-Gallardo Vicente J. , Paz-Alonso Pedro M. , Caballero-Gaudes César , Rodríguez-Oroz María C. 
Published: November 2023

AbstractThe study of mild cognitive impairment (MCI) is critical to understand the underlying processes of cognitive decline in Parkinson’s disease (PD). Functional connectivity (FC) disruptions in PD-MCI patients have been observed in several networks. However, the functional and cognitive changes associated with the disruptions observed in these networks are still unclear. Using a data-driven methodology based on independent component analysis, we examined differences in FC RSNs among PD-MCI, PD cognitively normal patients (PD-CN) and healthy controls (HC) and studied their associations with cognitive and motor variables. A significant difference was found between PD-MCI vs PD-CN and HC in a FC-trait comprising sensorimotor (SMN), dorsal attention (DAN), ventral attention (VAN) and frontoparietal (FPN) networks. This FC-trait was associated with working memory, memory and the UPDRS motor scale. SMN involvement in verbal memory recall may be related with the FC-trait correlation with memory deficits. Meanwhile, working memory impairment may be reflected in the DAN, VAN and FPN interconnectivity disruptions with the SMN. Furthermore, interactions between the SMN and the DAN, VAN and FPN network reflect the intertwined decline of motor and cognitive abilities in PD-MCI. Our findings suggest that the memory impairments observed in PD-MCI are associated with reduced FC within the SMN and between SMN and attention networks.
Noise analysis of Grover and phase estimation algorithms implemented as quantum singular value transformations for a small number of noisy qubits
Authors: Ijaz Muhammad Abdullah , Faryad Muhammad 
Published: November 2023

AbstractThe quantum singular value transformation (QSVT) algorithm is a general framework to implement most of the known algorithms and provides a way forward for designing new algorithms. In the present work, the impact of noise on the QSVT algorithm is examined for bit flip, phase flip, bit-phase flip, and depolarizing noise models for a small number of qubits. The small number of noisy qubits approximates the currently available noisy quantum computers. For simulation results, the QSVT implementation of the Grover search and quantum phase estimation (QPE) algorithms is considered. These algorithms are among the basic quantum algorithms and form the building blocks of various applications of quantum algorithms. The results showed that the QSVT implementation of the Grover search and QPE algorithms has a consistently worse dependence upon noise than the original implementation for all four noise models. The probability of success of the Grover algorithm and phase measured by the QPE algorithm were found to exponentially depend upon the error probability in the noisy channels but only linearly dependent on the number of qubits.
An open-label study evaluating the safety and efficacy of budesonide in patients with IgA nephropathy at high risk of progression
Authors: Obrișcă Bogdan , Vornicu Alexandra , Mocanu Valentin , Dimofte George , Andronesi Andreea , Bobeică Raluca , Jurubiță Roxana , Sorohan Bogdan , Caceaune Nicu , Ismail Gener 
Published: November 2023

AbstractWe sought to evaluate the efficacy and safety of budesonide (Budenofalk) in the treatment of patients with IgA Nephropathy. We conducted a prospective, interventional, open-label, single-arm, non-randomized study that enrolled 32 patients with IgAN at high risk of progression (BUDIGAN study, ISRCTN47722295, date of registration 14/02/2020). Patients were treated with Budesonide at a dose of 9 mg/day for 12 months, subsequently tapered to 3 mg/day for another 12 months. The primary endpoints were change of eGFR and proteinuria at 12, 24 and 36 months. The study cohort had a mean eGFR and 24-h proteinuria of 59 ± 24 ml/min/1.73m2 and 1.89 ± 1.5 g/day, respectively. Treatment with budesonide determined a reduction in proteinuria at 12-, 24- and 36-months by -32.9% (95% CI − 53.6 to − 12.2), − 49.7% (95% CI − 70.1 to − 29.4) and − 68.1% (95% CI − 80.6 to − 55.7). Budesonide determined an eGFR preservation corresponding to a 12-, 24- and 36-months change of + 7.68% (95% CI − 4.7 to 20.1), + 7.42% (95% CI − 7.23 to 22.1) and + 4.74% (95%CI − 13.5 to 23), respectively. The overall eGFR change/year was + 0.83 ml/min/y (95% CI − 0.54 to 4.46). Budesonide was well-tolerated, and treatment emergent adverse events were mostly mild in severity and reversible. Budesonide was effective in the treatment of patients with IgAN at high-risk of progression in terms of reducing proteinuria and preserving renal function over 36 months of therapy.
Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
Authors: Welch Darcy L. , Fridley Brooke L. , Cen Ling , Teer Jamie K. , Yoder Sean J. , Pettersson Fredrik , Xu Liping , Cheng Chia-Ho , Zhang Yonghong , Alexandrow Mark G. , Xiang Shengyan , Robertson-Tessi Mark , Brown Joel S. , Metts Jonathan , Brohl Andrew S. , Reed Damon R. 
Published: November 2023

AbstractOsteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a source of therapeutic resistance. In this study, we develop and evaluate an in vitro model of osteosarcoma heterogeneity based on phenotype and genotype. Cancer cell populations vary in their environment-specific growth rates and in their sensitivity to chemotherapy. We present the genotypic and phenotypic characterization of an osteosarcoma cell line panel with a focus on co-cultures of the most phenotypically divergent cell lines, 143B and SAOS2. Modest environmental (pH, glutamine) or chemical perturbations dramatically shift the success and composition of cell lines. We demonstrate that in nutrient rich culture conditions 143B outcompetes SAOS2. But, under nutrient deprivation or conventional chemotherapy, SAOS2 growth can be favored in spheroids. Importantly, when the simplest heterogeneity state is evaluated, a two-cell line coculture, perturbations that affect the faster growing cell line have only a modest effect on final spheroid size. Thus the only evaluated therapies to eliminate the spheroids were by switching therapies from a first strike to a second strike. This extensively characterized, widely available system, can be modeled and scaled to allow for improved strategies to anticipate resistance in osteosarcoma due to heterogeneity.
Comparative study of rainfall prediction based on different decomposition methods of VMD
Authors: Zhang Xianqi , Yin Qiuwen , Liu Fang , Li Haiyang , Qi Yu 
Published: November 2023

AbstractRainfall forecasting is an important means for macro-control of water resources and prevention of future disasters. In order to achieve a more accurate prediction effect, this paper analyzes the applicability of the "full decomposition" and "stepwise decomposition" of the VMD (Variational mode decomposition) algorithm to the actual prediction service; The MAVOA (Modified African Vultures Optimization Algorithm) improved by Tent chaotic mapping is selected; and the DNC (Differentiable Neural Computer), which combines the advantages of recurrent neural networks and computational processing, is applied to the forecasting. The different VMD decompositions of the MAVOA-DNC combination together with other comparative models are applied to example predictions at four sites in the Huaihe River Basin. The results show that SMFSD (Single-model Fully stepwise decomposition) is the most effective, and the average Root Mean Square Error (RMSE) of the forecasts for the four sites of SMFSD-MAVOA-DNC is 9.02, the average Mean Absolute Error (MAE) of 7.13, and the average Nash-Sutcliffe Efficiency (NSE) of 0.94. Compared with the traditional VMD full decomposition, the RMSE is reduced by 7.42, the MAE is reduced by 4.83, and the NSE is increased by 0.05; the best forecasting results are obtained compared with other coupled models.
Analysis of factors associated with the use of Korean medicine after spinal surgery using a nationwide database in Korea
Authors: Kim Doori , Lee Yoon Jae , Jang Bo-Hyoung , Park Jeong-Su , Park Sunju , D’Adamo Christopher R. , Shin Yong Cheol , Ko Seong-Gyu 
Published: November 2023

AbstractMany patients in Korea use Korean Medicine (KM) after spine surgery, but related research is lacking. Therefore, this retrospective cohort study aimed to analyze factors affecting the use and costs of KM using nationally representative data from the National Health Insurance Service-National Sample Cohort, South Korea. Patients who underwent spinal surgery for spinal diseases from 2011 to 2014 were followed up for 5 years, and their medical care was described. The association between patient and spinal surgery characteristics and the use of KM was analyzed. A two-part model was used to analyze factors affecting the use of KM in patients undergoing spinal surgery. Of 11,802 patients who underwent spinal surgery, 11,367 who met the inclusion criteria were included. Overall, 55.5% were female, 32.3% were aged ≥ 70 years, and 50.2% received KM treatment during the follow-up period. Open discectomy was the most common surgical procedure performed (58.6%), and 40.2% of surgeries were performed because of lumbar disc disorder. Female sex, older age, high Charlson Comorbidity Index score, and use of KM before surgery were associated with increased KM use and expenditure after surgery. In conclusion, patient characteristics, rather than surgical characteristics, appeared to be more strongly associated with the use of KM after surgery, particularly prior experience with KM use. This study is significant in that it analyzed the entire spine surgery to provide a comprehensive view of the use of KM after spine surgery and analyzed the impact of various factors related patients and surgical characteristics on KM use. The results of this study may be useful to patients with spinal diseases, clinicians, and policymakers.
Micelle assisted synthesis of bismuth oxide nanoparticles for improved chemocatalytic degradation of toxic Congo red into non-toxic products
Authors: Pious Aleena , Muthukumar Shreya , Singaravelu Dharshini Karnan , Nantheeswaran Periyappan , Mariappan Mariappan , Sivasubramanian Arvind , Ameen Fuad , Gancarz Marek , Veerappan Anbazhagan 
Published: November 2023

Bi2O3 NPs catalyze congo red decolourization and make it non-toxic.
GDF5
Authors: Piétri-Rouxel France , Falcone Sestina , Traoré Massiré 
Published: November 2023

La sarcopénie est une maladie musculaire complexe liée à l’âge qui affecte entre 10 à 16 % des personnes âgées de plus 65 ans. Elle se caractérise par une perte excessive de la masse musculaire et de la force. Malgré la multitude d’études visant à comprendre les mécanismes physiologiques qui sous-tendent cette pathologie, la physiopathologie de la sarcopénie reste encore mal comprise. A ce jour, il n’existe pas de traitement pharmacologique pour lutter contre cette pathologie. Dans ce contexte, notre équipe développe des approches thérapeutiques basées sur l’utilisation de la protéine GDF5 pour contrecarrer la perte de la masse et de la fonction musculaire dans diverses conditions pathologiques dont la sarcopénie. Après avoir décrypté un des mécanismes moléculaires régulant l’expression du GDF5, nous avons démontré le potentiel thérapeutique de cette protéine dans la préservation de la masse et la force musculaire chez les souris âgées.
Réseau microtubulaire et fonctionnalité du muscle strié squelettique
Authors: Castellano Léa , Gache Vincent 
Published: November 2023

Les muscles striés squelettiques sont constitués de cellules post-mitotiques et multinucléées : les fibres musculaires, dans lesquelles les noyaux sont régulièrement espacés et positionnés à leur périphérie. Ce positionnement spécifique des noyaux, nécessaire au bon fonctionnement du muscle, est essentiellement régulé par le réseau microtubulaire et ses partenaires protéiques. De nombreuses pathologies musculaires présentent une altération à la fois de l’organisation du réseau microtubulaire et du positionnement nucléaire, comme observé dans la Dystrophie Musculaire de Duchenne, les myopathies centronucléaires ou certaines maladies neuromusculaires. L’importance de l’interactome microtubulaire et son influence dans le maintien de l’homéostasie du muscle strié squelettique est un enjeu capital dans la compréhension des pathologies musculaires.
Anti-NMDA Autoimmune Encephalitis Post-COVID-19 Vaccination in a Pediatric Patient: A Case Report
Authors: Alabssi Haila , Almulhim Nouf F. , Al-Omari Mohammed , Safar Ayat H. 
Published: November 2023

AbstractPost-coronavirus disease 2019 (COVID-19) vaccination encephalitis is rarely reported particularly in the pediatric population. Herein, we report the first case of postvaccination anti-N-methyl-d-aspartate (NMDA) encephalitis in close temporal association with receiving COVID-19 vaccine in a pediatric patient. The patient is a 13-year-old female who received the first dose of the Pfizer–BioNTech COVID-19 vaccine and presented with subacute neurological and psychiatric symptoms and eventually confirmed the diagnosis of anti-NMDA autoimmune encephalitis. The patient recovered after receiving intravenous immunoglobulins and steroids.
Small-Molecule CO2 Donors Accelerate Three-Component Peptide/Protein Bioconjugation with Alkylazides and Phosphines in Ionic Liquids
Authors: Ohata Jun , Colella Brandon M. 
Published: November 2023

AbstractDevelopment of chemical modification techniques for peptides and proteins has been facilitated by a set of multicomponent reactions to date. This Letter demonstrates the use of small-molecule CO2 donors to promote reaction efficiency of the coupling of alkylamine on peptides and proteins with azide-derived iminophosphorane and carbon dioxide.
Nickel-Catalyzed Hydroalkynylation of 1,3-Dienes with Simple Alkynes
Authors: Xiao Li-Jun , Yao Bo-Ying , Xiao Wei-Guo , Zhou Qi-Lin 
Published: November 2023

AbstractA hydroalkynylation reaction of 1,3-dienes with simple alkynes, facilitated by an efficient nickel catalyst system with the 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (Xantphos) ligand, is presented. This reaction displays a broad substrate range for alkynes, encompassing both aryl alkynes and alkyl alkynes, thereby overcoming previous constraints in 1,3-diene hydroalkynylation. The method offers a convenient and direct means for obtaining allylic alkynes with high atom and step economy.
Fetal Autopsy—A Game Changer!
Authors: Elayedatt Rinshi Abid , Krishnan Vivek , Chandraprabha Vidya 
Published: November 2023

AbstractFetal autopsy is one of the most useful investigations that can change or significantly add to the clinical diagnosis despite a prenatal ultrasonographic diagnosis of a fetal abnormality. It is often required to determine the cause of intrauterine death or miscarriages, provide recurrence risk, and is known to alter the final diagnosis and genetic counseling in nearly half of the cases. This article reviews the role of fetal autopsy and discusses its contributory role in confirming the diagnosis and its usefulness in the genetic counseling of cases with risk of recurrence in future pregnancies.
Fetal Abdominal Cyst as a Stage of Meconium Peritonitis after Fetoscopic Laser Photocoagulation
Authors: Tsikhanenka Iryna , Beluga Maxim , Semenchuk Venera , Kurlovich Ivan , Marahovskaya Ella 
Published: November 2023

AbstractFetal meconium peritonitis (FMP) is a rare form of sterile chemical peritonitis occurring in utero due to the perforation of the fetal intestine, sometimes after fetoscopic laser photocoagulation (FLP) in twin-to-twin transfusion syndrome, with the broad spectrum of prenatal ultrasound manifestations including abdominal cyst. We report a unique presentation of FMP following FLP with ascites, pseudocyst formation, and the cyst resolving probably of a fistula formation. This case report highlights unusual FMP development and gives a novel clue to antenatal diagnosis and management.
Unusual Anterior Neck Swelling: Cervical Spinal Cord Schwannoma
Authors: Özgiray Erkin , Karagöz Cihat , Bölük Serdar , Balak Naci 
Published: November 2023

AbstractSchwannomas are typically solitary, well-encapsulated, benign tumors running along or attached to a nerve. An intradural-extramedullary cervical spinal schwannoma, which first manifests as a swelling in the anterior neck, has not been reported to the best of our knowledge. We present the case of a 69-year-old patient complaining of a gradually worsening painful left cervical swelling for over 8 years. First, a posterior spinal midline approach was performed for the resection of the tumor and the tumor portion in the vertebral canal was totally removed. The second operation, the anterolateral approach, was planned to be executed in a second surgical session. The patient was discharged from the hospital without neurological deficits. Histopathological diagnosis was a schwannoma. The first aim of surgery is to treat neurological deficits in patients with cervical intraspinal schwannomas with/without extension into the extra-vertebral paravertebral neck regions. The surgical strategy combines the posterior midline and the anterolateral cervical approaches in the same session or at different times.
Raman spectrometry measurements for the 2D mapping of the degradation products on aged graphite anodes of cylindrical Li-ion battery cells
Authors: Jabri Slaheddine , Pitta Bauermann Luciana , Vetter Matthias 
Published: November 2023

Here, Raman spectroscopy is shown to be a suitable method for post-mortem analysis to localize and identify degradation products on the surface of Li-ion battery electrode layers. Cylindrical battery cells are charged and discharged at 4° C for up to 250 cycles. The degradation products detected on the surface of graphite anodes are shown in 2D Raman mapping and discussed. The battery cells were cycled in an argon-filled glove box. The air-sensitive electrode layers were covered on both sides with coverslips transparent to the Raman laser to keep them without coming into contact with air during the measurements. The LiFePO4 cathode showed no detectable degradation during the aging process. The vibrations of lithium acetylide species (Li–C≡C–X) at 1850 cm−1 are used to detect lithium-containing degradation products on the surface of graphite anodes. Vibrational modes corresponding to polyacetylene at 1118 and 1497 cm−1 were observed for the first time on the aged graphite layers. The described analytical method and electrode preparation are particularly relevant for the identification and localization of degradation products on environmentally sensitive electrodes of Li-ion battery cells.