bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergent growth of system self‐organization and self‐control: Contextual system design, steering, and transformation
Authors: Henshaw Jessie Lydia 
Published: October 2023

AbstractIn physics, subjects not explained by formulas were often avoided, like how uncontrolled systems change form. Weather, businesses, societies, environments, communities, cultures, groups, relationships, lives, and livelihoods all change form by variations of “S” curve progressions. It is a slow‐fast‐slow process of self‐animated contextual energy‐system emergence of working designs. They also appear to develop by “find and connect” in three stages, starting small to first (a) grow designs of increasing power, then (b) diversify, adapt, respond, to harmonize internally and with others, and then (c) take on one or more roles in their climax environments. It starts as a long life‐curve of increasing syntropic success that later ends with a continuity of entropic decline. Life is particularly risky for small startups, but many do succeed. Many powerful civilizations have emerged, some never growing up but growing as endless startups, only to become fragile, fail, and vanish. Here, we explore these systems with the premise that dynamic self‐organization and adaptation are also inherently processes of self‐direction.
Circularity of resources in the craft brewery segment: An analysis supported by innovation
Authors: Julkovski Dulcimar José , Sehnem Simone , Lara Ana Cláudia , Ramos Maria da Conceição Pereira 
Published: October 2023

AbstractThis article analyzes how the circularity of resources occurs in Brazilian craft breweries supported by innovation and proposes the creation of alternative craft breweries to promote circular economy. Data were collected through 11 interviews with entrepreneurs in the craft brewery segment, checklist application, and access to the website of the cases investigated. Our results expand the relationship with innovation suggesting that: (a) the circularity of resources is still focused on several long‐cycle practices; (b) short cycles, which are the most desired for the retention of resource value in the production chain, are already present, but demand more attention from the enterprises surveyed; (c) innovation practices can become barriers to or drivers for the feasibility of circular economy in the beer context; (d) technical cycles are consolidated in most of the researched cases, while biological cycles still demand greater engagement from all stakeholders; (e) the nature and content of circular practices imply different adoption stages in the cases investigated; (f) companies invest in strengthening the relationship with consumers and suppliers in order to obtain support for current circular strategies in their ventures.
Whole‐genome sequencing analysis in fetal structural anomalies: novel phenotype–genotype discoveries
Authors: Qi Q. , Jiang Y. , Zhou X. , Lü Y. , Xiao R. , Bai J. , Lou H. , Sun W. , Lian Y. , Hao N. , Li M. , Chang J. 
Published: October 2023

ABSTRACTObjectivesThe identification of structural variants and single‐nucleotide variants is essential in finding molecular etiologies of monogenic genetic disorders. Whole‐genome sequencing (WGS) is becoming more widespread in genetic disease diagnosis. However, data on its clinical utility remain limited in prenatal practice. We aimed to expand our understanding of implementing WGS in the genetic diagnosis of fetal structural anomalies.MethodsWe employed trio WGS with a minimum coverage of 40× on the MGI DNBSEQ‐T7 platform in a cohort of 17 fetuses presenting with aberrations detected by ultrasound, but uninformative findings of standard chromosomal microarray analysis (CMA) and exome sequencing (ES).ResultsCausative genetic variants were identified in two families, with an increased diagnostic yield of 11.8% (2/17). Both were exon‐level copy‐number variants of small size (3.03 kb and 5.16 kb) and beyond the detection thresholds of CMA and ES. Moreover, to the best of our knowledge, we have described the first prenatal instance of the association of FGF8 with holoprosencephaly and facial deformities.ConclusionsOur analysis demonstrates the clinical value of WGS in the diagnosis of the underlying etiology of fetuses with structural abnormalities, when routine genetic tests have failed to provide a diagnosis. Additionally, the novel variants and new fetal manifestations have expanded the mutational and phenotypic spectrums of BBS9 and FGF8. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.
The state‐of‐art review of ultra‐precision machining using text mining: Identification of main themes and recommendations for the future direction
Authors: YIP Wai Sze , Yan Hengzhou Edward , Zhang Baolong , To Suet 
Published: October 2023

AbstractUltra‐precision machining (UPM), one of the most advanced machining techniques that can produce exact components, significantly impacts the technological community. The significance of UPM attracts the attention of academic and industrial partners. As a result of the rapid development of UPM caused by technological advancement, it is necessary to revisit the current stages and evolution of UPM to sustain and advance this technology. The state of the art in UPM is first investigated systematically in this study by identifying the current four major UPM themes. The UPM thematic network is then built, along with a structural analysis of the network, to determine the interactions between each theme and the primary roles of theme members responsible for the interactions. Furthermore, the “bridge” role is assigned to the specific UPM theme content. On the other hand, Sentiment analysis is conducted to determine how the academic community at UPM feels about the themes for UPM research to focus on those themes with a need for more confidence. Considering the above findings, the future perspective of UPM and suggestions for its advancement are discussed and provided. This study provides a comprehensive understanding and the current state‐of‐the‐art review of UPM technology by a text mining technique to critically analyze its research content, as well as suggestions to enhance UPM development by focusing on its current challenges, thereby assisting academia and institutions in leveraging this technology to benefit society.This article is categorized under:
Algorithmic Development > Text Mining
Application Areas > Science and Technology
Application Areas > Industry Specific Applications
Teilhabe als Gesundheitsfaktor
Authors: Wacker Elisabeth , Beck Iris , Brandt Martina , Köbsell Swantje , Lippke Sonia , Niehaus Mathilde 
Published: October 2023

Zusammenfassung
Teilhabechancen

spielen im Kontext von Gesundheit eine wichtige Rolle. Diesen Zusammenhang betont das

bio-psycho-soziale Modell von Behinderung

, das auch Grundlage des Bundesteilhabe- und des

Teilhabestärkungsgesetz

es ist. Gleichzeitig machen die dort zum Tragen kommenden Definitionen von Behinderung deutlich, dass diese nicht naturwüchsig ist, sondern erst im Zusammenspiel von individuellen Beeinträchtigungen und gesellschaftlichen Barrieren entsteht. Im Zuge der Veränderung der

Sozialgesetzgebung

rückt auch das Thema „Behinderung und Gesundheit“ mehr in den Fokus. Das Kapitel klärt zunächst die zentralen Begriffe, stellt dann statistische Daten rund um das „Leben mit Beeinträchtigungen und Behinderung in Deutschland“ vor und verbindet diese mit dem Thema Gesundheit. Mit Hilfe der

Teilhabeberichterstattung

der Bundesregierung wird auf die noch unbefriedigende Datenlage zum Zusammenhang von Beeinträchtigungen, Behinderung und Gesundheit verwiesen. Das Kapitel betrachtet im Licht der ICF der WHO, welche Rolle das BTHG in diesem Kontext spielt und welche Bedeutung dabei Prävention haben muss. Ein Exkurs zur

Prävention

in besonderen Wohnformen zeigt mit einer

Feldstudie

exemplarisch auf, welche Perspektiven das Fachpersonal und auch die dort lebenden Menschen mit Beeinträchtigungen auf

Prävention

haben. Unter Bezug auf den Ansatz der

Salutogenese

wird die Bedeutung des

demographischen Wandel

s für das Thema Gesundheit und Behinderung behandelt sowie die Frage, was beeinträchtigte Menschen im Laufe ihres Lebens gesund hält. Schließlich wird ausgelotet, wie

Gesundheitskompetenz

en von Menschen mit Beeinträchtigungen durch den Abbau von Barrieren erweitert werden können. Eine Auswertung erster Ergebnisse der repräsentativen

Teilhabebefragung

rundet das Kapitel ab. Mit diesen Daten soll es möglich werden, die Sicht von Menschen mit und ohne Beeinträchtigungen auf den Zugang zur gesundheitlichen Versorgung zu vergleichen. Damit werden zahlreiche Versorgungslücken bzw. Zugangsbarrieren deutlich. Für die Umsetzung von Art. 25 UN-BRK – die Inanspruchnahme von

Gesundheitsangebote

n gleichberechtigt mit der Mehrheitsgesellschaft – bedarf es demnach noch großer Anstrengungen.
Impact of hyaluronic acid injection on the knee joint friction
Authors: de Roy Luisa , Eichhorn Kerstin , Faschingbauer Martin , Schlickenrieder Klaus , Ignatius Anita , Seitz Andreas Martin 
Published: October 2023

AbstractPurposeThe purpose of this in vitro study was to investigate whether or not hyaluronic acid supplementation improves knee joint friction during osteoarthritis progression under gait‐like loading conditions.MethodsTwelve human cadaveric knee joints were equally divided into mild and moderate osteoarthritic groups. After initial conservative preparation, a passive pendulum setup was used to test the whole joints under gait‐like conditions before and after hyaluronic acid supplementation. The friction‐related damping properties given by the coefficient of friction µ and the damping coefficient c (in kg m2/s) were calculated from the decaying flexion–extension motion of the knee. Subsequently, tibial and femoral cartilage and meniscus samples were extracted from the joints and tested in an established dynamic pin‐on‐plate tribometer using synthetic synovial fluid followed by synthetic synovial fluid supplemented with hyaluronic acid as lubricant. Friction was quantified by calculating the coefficient of friction.ResultsIn the pendulum tests, the moderate OA group indicated significantly lower c0 values (p < 0.05) under stance phase conditions and significantly lower µ0 (p = 0.01) values under swing phase conditions. No degeneration‐related statistical differences were found for µend or cend. Friction was not significantly different (p > 0.05) with regard to mild and moderate osteoarthritis in the pin‐on‐plate tests. Additionally, hyaluronic acid did not affect friction in both, the pendulum (p > 0.05) and pin‐on‐plate friction tests (p > 0.05).ConclusionThe results of this in vitro study suggested that the friction of cadaveric knee joint tissues does not increase with progressing degeneration. Moreover, hyaluronic acid viscosupplementation does not lead to an initial decrease in knee joint friction.
Protective effects of Gαi3 deficiency in a murine heart-failure model of β1-adrenoceptor overexpression
Authors: Schröper Tobias , Mehrkens Dennis , Leiss Veronika , Tellkamp Frederik , Engelhardt Stefan , Herzig Stefan , Birnbaumer Lutz , Nürnberg Bernd , Matthes Jan 
Published: October 2023

AbstractWe have shown that in murine cardiomyopathy caused by overexpression of the β1-adrenoceptor, Gαi2-deficiency is detrimental. Given the growing evidence for isoform-specific Gαi-functions, we now examined the consequences of Gαi3 deficiency in the same heart-failure model. Mice overexpressing cardiac β1-adrenoceptors with (β1-tg) or without Gαi3-expression (β1-tg/Gαi3−/−) were compared to C57BL/6 wildtypes and global Gαi3-knockouts (Gαi3−/−). The life span of β1-tg mice was significantly shortened but improved when Gαi3 was lacking (95% CI: 592–655 vs. 644–747 days). At 300 days of age, left-ventricular function and survival rate were similar in all groups. At 550 days of age, β1-tg but not β1-tg/Gαi3−/− mice displayed impaired ejection fraction (35 ± 18% vs. 52 ± 16%) compared to wildtype (59 ± 4%) and Gαi3−/− mice (60 ± 5%). Diastolic dysfunction of β1-tg mice was prevented by Gαi3 deficiency, too. The increase of ANP mRNA levels and ventricular fibrosis observed in β1-tg hearts was significantly attenuated in β1-tg/Gαi3−/− mice. Transcript levels of phospholamban, ryanodine receptor 2, and cardiac troponin I were similar in all groups. However, Western blots and phospho-proteomic analyses showed that in β1-tg, but not β1-tg/Gαi3−/− ventricles, phospholamban protein was reduced while its phosphorylation increased. Here, we show that in mice overexpressing the cardiac β1-adrenoceptor, Gαi3 deficiency slows or even prevents cardiomyopathy and increases shortened life span. Previously, we found Gαi2 deficiency to aggravate cardiac dysfunction and mortality in the same heart-failure model. Our findings indicate isoform-specific interventions into Gi-dependent signaling to be promising cardio-protective strategies.
Computed tomography radiomics identification of T1–2 and T3–4 stages of esophageal squamous cell carcinoma: two-dimensional or three-dimensional?
Authors: Li Yang , Yang Li , Gu Xiaolong , Wang Qi , Shi Gaofeng , Zhang Andu , Yue Meng , Wang Mingbo , Ren Jialiang 
Published: October 2023

Abstract
Background
To evaluate two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) radiomics analysis for the T stage of esophageal squamous cell carcinoma (ESCC).

Methods
398 patients with pathologically confirmed ESCC were divided into training and testing sets. All patients underwent chest CT scans preoperatively. For each tumor, based on CT images, a 2D region of interest (ROI) was outlined on the largest cross-sectional area, and a 3D ROI was outlined layer by layer on each section of the tumor. The radiomics platform was used for feature extraction. For feature selection, stepwise logistic regression was used. The receiver operating characteristic (ROC) curve was used to assess the diagnostic performance of the 2D radiomics model versus the 3D radiomics model. The differences were compared using the DeLong test. The value of the clinical utility of the two radiomics models was evaluated.

Results
1595 radiomics features were extracted. After screening, two radiomics models were constructed. In the training set, the difference between the area under the curve (AUC) of the 2D radiomics model (AUC = 0.831) and the 3D radiomics model (AUC = 0.830) was not statistically significant (p = 0.973). In the testing set, the difference between the AUC of the 2D radiomics model (AUC = 0.807) and the 3D radiomics model (AUC = 0.797) was also not statistically significant (p = 0.748). A 2D model was equally useful as a 3D model in clinical situations.

Conclusion
The performance of 2D radiomics model is comparable to that of 3D radiomics model in distinguishing between the T1-2 and T3-4 stages of ESCC. In addition, 2D radiomics model may be a more feasible option due to the shorter time required for segmenting the ROI.
Shaping a suitable EU HTA dossier template: why the German template is not fit for purpose
Authors: Schweitzer Maria Katharina , Dold Manuel Nico , Genet Astrid , Gossens Klaus , Klein-Hessling Thomas , Löffler Nils , Rabel Matthias , Rasch Andrej , Reuter Eva-Maria , Schmelcher Jessica , Wolfram Natalia , Werner Sebastian 
Published: October 2023

AbstractFrom 2025, Health Technology Developers (HTDs) have to submit EU HTA dossiers. The joint clinical assessment (JCA) aims to streamline HTA processes and access to medicinal products across Europe. Currently, German HTA bodies IQWiG and G-BA actively shape the JCA methodology. Here we examine if German HTA dossier requirements are suitable for the JCA. We compare the number of safety endpoint and subgroup analyses in German dossiers with analyses considered in IQWIG’s benefit assessment and evaluate if these analyses were considered by the G-BA. We further investigated how the number of analyses was affected by the latest change in the German dossier template. With the current template, HTDs report in median 2.6 times more analyses on adverse events (AE) and 1.1 times more subgroup categories than in the previous template. IQWiG does not consider 33% of AE analyses and 73% of the subgroup categories presented by the HTD under the current template. G-BA considered the same AE as IQWiG in 76% of cases. Subgroups were uncommented by G-BA in most cases, independent of the template (previous: 93%, current 85%) and unconsidered in the conclusion on additional benefit (previous: 77%, current 69%). Thus, changes in the dossier template drastically increased HTD workload, but additional analyses seem unconsidered by the HTA bodies. With a broader scope in JCA, this effect could be amplified. To mitigate duplicative efforts and ensure prompt availability of medicinal products as envisioned by the HTAR, we suggest well-chosen and precise dossier requirements, early consultations, and early HTD engagement.
A predictive model for planning emergency events rescue during COVID-19 in Lombardy, Italy
Authors: Andreella Angela , Mira Antonietta , Balafas Spyros , Wit Ernst-Jan C. , Ruggeri Fabrizio , Nattino Giovanni , Ghilardi Giulia , Bertolini Guido 
Published: October 2023

AbstractForecasting the volume of emergency events is important for resource utilization in emergency medical services (EMS). This became more evident during the COVID-19 outbreak when emergency event forecasts used by various EMS at that time tended to be inaccurate due to fluctuations in the number, type, and geographical distribution of these events. The motivation for this study was to develop a statistical model capable of predicting the volume of emergency events for Lombardy’s regional EMS called AREU at different time horizons. To accomplish this goal, we propose a negative binomial additive autoregressive model with smoothing splines, which can predict over-dispersed counts of emergency events one, two, five, and seven days ahead. In the model development stage, a large set of covariates was considered, and the final model was selected using a cross-validation procedure that takes into account the observations’ temporal dependence. Comparisons of the forecasting performance using the mean absolute percentage error showed that the proposed model outperformed the model used by AREU, as well as other widely used forecasting models. Consequently, AREU decided to adopt the new model for its forecasting purposes.
Wrong Way Risk corrections to CVA in CIR reduced-form models
Authors: Antonelli Fabio , Ramponi Alessandro , Scarlatti Sergio 
Published: October 2023

AbstractIn this paper we provide an efficient methodology to compute the credit value adjustment of a European contingent claim subject to some default event concerning the issuer solvability, when the underlying and the default event are correlated. In particular, in a Black and Scholes market/CIR intensity-default model, we consider a second order expansion around the origin of a vulnerable call option with respect to a correlation parameter$$\rho$$ρ, which may be used to describe the wrong way risk of the contract, measuring the dependence between the underlying asset price and the option’s issuer default intensity. Numerical implementations of this approach are compared with the benchmark Monte Carlo simulations.
Machine learning-based multipath modeling in spatial domain applied to GNSS short baseline processing
Authors: Pan Yuanxin , Möller Gregor , Soja Benedikt 
Published: October 2023

AbstractMultipath is the main unmodeled error source hindering high-precision Global Navigation Satellite System data processing. Conventional multipath mitigation methods, such as sidereal filtering (SF) and multipath hemispherical map (MHM), have certain disadvantages: They are either not easy to use or not effective enough for multipath mitigation. In this study, we propose a machine learning (ML)-based multipath mitigation method. Multipath modeling was formulated as a regression task, and the multipath errors were fitted with respect to azimuth and elevation in the spatial domain. We collected 30 days of 1 Hz GPS data to validate the proposed method. In total, five short baselines were formed and multipath errors were extracted from the postfit residuals. ML-based multipath models, as well as observation-domain SF and MHM models, were constructed using 5 days of residuals before the target day and later applied for multipath correction. It was found that the XGBoost (XGB) method outperformed SF and MHM. It achieved the highest residual reduction rates, which were 24.9%, 36.2%, 25.5% and 20.4% for GPS P1, P2, L1 and L2 observations, respectively. After applying the XGB-based multipath corrections, kinematic positioning precisions of 1.6 mm, 1.9 mm and 4.5 mm could be achieved in east, north and up components, respectively, corresponding to 20.0%, 17.4% and 16.7% improvements compared to the original solutions. The effectiveness of the ML-based multipath model was further validated using 30 s sampling data and data from a low-cost device. We conclude that the ML-based multipath mitigation method is effective, easy to use, and can be easily extended by adding auxiliary input features, such as signal-to-noise ratio, during model training.
Evaluating the Impact of Inclined Cutoff-Wall to Control Seawater Intrusion in Heterogeneous Coastal Aquifers
Authors: Emara Sobhy R. , Gado Tamer A. , Zeidan Bakenaz A. , Armanuos Asaad M. 
Published: October 2023

AbstractSubsurface physical barriers have been effectively used to mitigate seawater intrusion (SWI). Traditionally, the primary emphasis in both numerical studies and practical implementations has been on vertical barriers. The current research aims to explore the dynamics of SWI under various cutoff-wall inclination angles and depths, as well as aquifer heterogeneity using both experimental and numerical simulations. The impact of aquifer characteristics was assessed by utilizing a low hydraulic conductivity (K) aquifer (case L), a high hydraulic conductivity aquifer (case H), and two stratified aquifers. The stratified aquifers were created by grouping different hydraulic conductivity layers into two cases: high K above low K (case H/L) and low K above high K (case L/H). The model simulations covered seven different cutoff-wall inclination angles: 45.0°, 63.4°, 76.0°, 90.0°, 104.0°, 116.6°, and 135.0°. The maximum repulsion ratio of SWI wedge length was observed at an inclination angle of 76.0° for cutoff-wall depth ratios up to 0.623. However, as the depth ratio increased to 0.811, the maximum repulsion ratio shifted to an angle of 63.4° for all aquifers studied. At an inclined cutoff depth ratio of 0.811, the cutoff-wall inclination angle of 45.0° had the most significant impact on the saltwater wedge area. This results in SWI area reductions of 74.9%, 79.8%, 74.7%, and 62.6% for case L, case H, case H/L, and case L/H, respectively. This study provides practical insights into the prevention of SWI. Nevertheless, a thorough cost–benefit analysis is necessary to assess the feasibility of constructing inclined cutoff-walls.