bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized chemotherapy and efficacy analysis of hepatoblastoma in children
Authors: Hu Huimin , Zhang Weiling , Zhang Yi , Gao Yanan , Zhi Tian , Li Fan , Li Jing , Gu Huali , Liao Ru , Wu Runhui , Huang Dongsheng 
Published: November 2023

AbstractPurposeWe aimed to assess the clinical utility of the mini patient‐derived xenograft (MiniPDX) model in screening individualized chemotherapy regimens for pediatric hepatoblastoma.Materials and methodsWe included 31 children with hepatoblastoma who had unsatisfactory decreases in alpha‐fetoprotein levels during neoadjuvant chemotherapy or poor clinical control of recurrence with or without metastasis. We established a MiniPDX model using surgically resected tumor tissue specimens. The sensitivities of five chemotherapeutic regimens were tested to determine the one with the lowest tumor proliferation rate, which was then set as the experimental group. We compared the clinical characteristics and efficacy with those of conventional chemotherapy regimens.ResultsThe median follow‐up period for the experimental group was 27 months, with a complete remission (CR) rate of 80.64%. Among stage IV cases, there was a significant between‐group difference in CR rate (experimental [73.68%] vs. control [37.5%]) and 3‐year event‐free survival rate (79.3% vs. 26.7%). The most effective individualized chemotherapy regimens were ifosfamide + pirarubicin + etoposide + carboplatin (54.84%), followed by pirubicin + cyclophosphamide + cisplatin (16.13%), ifosfamide + carboplatin + etoposide (12.90%), cisplatin + 5‐fluorouracil + vincristine + adriamycin (12.90%), and vincristine + irinotecan + cyclophosphamide + cisplatin (3.23%).ConclusionUsing the MiniPDX model to screen individualized chemotherapy regimens for pediatric hepatoblastoma can significantly improve the CR rate.
The impact of radiation therapy variables on pediatric high‐grade glioma outcomes: A National Cancer Database analysis
Authors: Williamson Christopher , Williamson Shayla , Jiang Renjian , Sudmeier Lisa , Esiashvili Natia , Eaton Bree R. 
Published: November 2023

AbstractPurposeThe purpose of this analysis is to report patterns of care for pediatric patients with high‐grade glioma (pHGG) and evaluate the impact of radiotherapy (RT) variables on outcomes using the National Cancer Database (NCDB).MethodsEligibility criteria included age < 22 years, histologically diagnosed WHO grade III‐IV gliomas treated with ≥50 Gy and < 76 Gy RT between 2004 and 2013, and RT initiation within 90 days of diagnosis. RT variables including RT dose, RT timing, and RT modality were analyzed along with baseline demographic, tumor, and treatment variables to assess the impact on overall survival.ResultsA total of 498 pHGG patients were included. The median age was 15 years (range, 0‐21), common diagnoses were astrocytoma (55%) and glioblastoma (30%), 73.5% underwent surgical resection and 90.2% received chemotherapy. The median RT dose was 59.4 Gy (SD 2.9 Gy) starting at a median of 4.4 weeks from diagnosis (SD 2.5 weeks). Fourteen patients were treated with proton therapy. Median follow‐up was 19.6 months with 1‐ and 3‐year overall survival of 78.4% and 40.4%, respectively. On multivariable analysis, female gender, older age, and RT delay of ≥6 weeks were significantly associated with a lower rate of death; glioblastoma histology, no surgical resection/biopsy only, and earlier RT initiation < 6 weeks from diagnosis were associated with a higher rate of death. There was no relationship between RT dose or proton versus photon therapy and overall survival.ConclusionsOutcomes for pHGG are poor. There was no benefit to early RT timing when RT is initiated within 90 days of diagnosis or higher RT dose in this dataset.
Buckling analysis of composite plates surface bonded with graphene‐reinforced piezoelectric actuators
Authors: Jin Qilin , Leng Longlong , Yang Shengqi 
Published: November 2023

AbstractGraphene is a highly conductive and exceptional material that has shown potential for significantly improving the piezoelectric and mechanical properties of piezoelectric matrix. This paper examines the stability of composite plates surface bonded with graphene‐reinforced composite piezoelectric (GRCP) actuators. However, the significant differences in material characteristics at the interfaces will pose some challenges in analyzing the buckling behavior of piezoelectric composite plates by means of existing higher‐order shear deformation theories. To address this issue, a refined plate theory is developed for the buckling analysis of piezoelectric composite plates. The developed theory includes a new interlaminar shear stress field that precisely describes the distribution of interlaminar shear stresses, which differs from earlier higher‐order theories. It should be emphasized that the finite element formulation can be simplified by removing the second‐order derivatives of in‐plane displacement parameters from interlaminar shear stresses. In terms of the developed theory, a four‐node C0 quadrilateral plate element is introduced to examine the buckling behavior of piezoelectric composite plates. Furthermore, the modified interlaminar shear stress field is absorbed into the strain energy, significantly improving the ability to predict the critical loads of composite plates with GRCP actuators. The refined plate model is evaluated through the utilization of three‐dimensional (3D) elasticity solutions and results obtained from other associated theories. Numerical results demonstrate that the refined plate model is capable of producing favorable results, and a comprehensive examination is conducted to analyze the effects of significant parameters on the buckling behaviors of piezoelectric composite plates. This study sets a solid foundation for future research and development on the application of graphene‐reinforced composite piezoelectric actuators in composite structures.Highlights
Buckling analysis of composite plates with GRCP actuators is conducted.
A refined plate theory with modified interlaminar shear stresses is developed.
The ability to predict critical loads can be significantly improved.
The finite element formulation can be simplified based on the proposed model.
Comprehensive parametric studies on buckling behavior are caried out.
Mapping oft the optimal mechanical responses in commercial‐grade HTPB‐based binders
Authors: Cardoso Renata Fraga , Kawachi Elizabete Yoshie , Dias Villar Luciene 
Published: November 2023

AbstractAlternative binders for composite solid propellants (CSP) have always been a concern. One of the closest alternative to the broadly used military‐grade hydroxyl‐terminated polybutadiene (HTPB) would be its commercial‐grade. Factorial design of experiments (DoE) was applied to optimize the mechanical properties of the binder. Commercial‐grade HTPB was used, in addition to 1,4‐butanediol (BDO) as chain extender, and either isophorone diisocyanate (IPDI) or 4,4’‐methylenedicyclohexyl diisocyanate (H12MDI) as curing agents. The effect of simultaneously varying two factors: [NCO]/[OH] molar ratio, and BDO:HTPB mass fraction on the mechanical properties of the binder was evaluated. DoE gave the optimal conditions at 0.68 molar ratio, and 0.71 % BDO:HTPB mass fraction for IPDI; and at 0.66 and 0.57 %, respectively, for H12MDI. Higher strength was observed for binders formulated with H12MDI. At the optimal conditions, CSP formulated with commercial HTPB showed higher strength than CSP formulated with military HTPB. Moreover, with H12MDI higher elongation was observed (28±4 %) when compared to IPDI (19±1%). Thus, the former is a promising diisocyanate for tailoring CSP formulations with commercial‐grade HTPB.
Capturing the science behind the craft: a reporting framework to improve quality and confidence in nonsimulated models
Authors: Turner Benjamin L. , Goodman Michael 
Published: November 2023

AbstractQualitative nonsimulated models (causal loop diagrams, stock‐flow diagrams, or hybrids of both) have been used since within a decade after the inception of system dynamics (SD). In this article, we assert that the well‐known weaknesses of nonsimulated models need to be balanced against the contexts, purposes, and strengths that nonsimulated models provide. We propose a framework consisting of a set of best practices for model reporting and documentation that would improve the quality, consistency, and transparency of nonsimulated models. Several high‐quality examples are described and referenced in the framework to illustrate support of each criterion. The framework's purpose is help improve the transparency around the creation and evaluation of nonsimulated models, thereby enhancing their confidence and legitimate use in SD practice. Ultimately, high‐quality nonsimulated models can offer broader access to the powerful body of SD knowledge to audiences likely never to have access to formal SD simulation models. © 2023 System Dynamics Society.
A Combined Theoretical and Experimental Investigation of 3D Ternary Perovskite‐Like Silver Iodobismuthate
Authors: Nair Shruthi , Kashid Vikas , Punde Ashvini , Shah Shruti , Waghmare Ashish , Hase Yogesh , Shinde Pratibha , Bade Bharat , Doiphode Vidya , Ladhane Somnath , Rahane Swati , Rondiya Sachin , Pathan Habib , Prasad Mohit , Jadkar Sandesh 
Published: November 2023

AbstractLead‐free ternary bismuth halide perovskites A3Bi2X9 have gained much attention as a solution for toxic and unstable lead halide perovskites due to their facile solution processability, high optical absorption coefficient, and high stability. However, their photovoltaic performance remains poor due to their wide bandgap (∼2 eV), and poor charge transport properties stem from their low‐dimensional crystal structure. To promote the 3D structure and reduce the bandgap of ternary Bi‐halide perovskites, we replace the alkali elements at the A‐site with the transition element Ag+ to obtain a new class of perovskite‐like materials named rudorffites AgaBibIa+3b. We investigated the photophysical properties of AgBiI4 by a combined theoretical and experimental approach. Our DFT‐PBE‐SOC predicted band gap for cubic defect spinel AgBiI4 is 2.01 eV, while that obtained for spin‐coated AgBiI4 film is 1.67 eV. Furthermore, the strong p‐p band edge transition leads to high optical absorption in this material. Finally, a photodetector device fabricated using AgBiI4 shows excellent photoresponsivity (183 μA/W) and detectivity (20.93×108 Jones) with a fast rise/decay time of 0.27 s/0.29 s. This newly explored semiconductor class can be a promising and stable choice for advanced optoelectronic devices.
Microwave‐Assisted Soft Method for Synthesis of Poly (Acrylic Acid)/Organo‐clay Composites: Application As Superabsorbent For Phenol and Cr (VI)
Authors: Djamaa Zoulikha , Chebout Redouane , Bachari Khaldoun , Lerari Djahida 
Published: November 2023

AbstractA series of superabsorbent composites (PAA/HDTMA‐MMT) based on poly (acrylic acid) (PAA) and different content of organo‐modified natural clay HDTMA‐MMT (1,3 and 5 wt.%) were synthesized via in‐situ radical polymerization using microwave method. This eco‐friendly route was chosen to avoid the use of toxic solvents and reduce polymerization time. In addition, it can be considered an efficient approach for industrial‐scale polymer synthesis. The microstructure of the obtained hydrogels was evidenced by Fourier transformation infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and scanning electron microscopy (SEM). Thermal stability was examined according to nano‐filler content on the matrix. The composite (PAA/HDTMA‐MMT) at 3 wt % exhibits an important swelling capacity value (833.33 g g−1). The efficiency of the synthesized hydrogel composites for phenol and Cr (VI) uptakes from aqueous solutions was studied in batch experiments. The main reason for their selection is their remarkable industrial use, despite their high toxicity and persistence in the environment. In order to underline the mechanism of the phenol and Cr (VI) adsorptions on the (PAA/HDTMA‐MMT), respectively, the zeta potential of the hydrogel was evaluated. Maximum adsorption capacity values of 170.7 mg g−1 and 197.3 mg g−1 were screened for phenol and Cr(VI), respectively. The adsorption process concurs with pseudo‐second‐order kinetics and with the Langmuir isotherm equation. A very high adsorption capacity (qmax=225.2 mg g−1) and a correlation coefficient of 0.998 calculated from isotherm equations show the high efficiency of the adsorbent and thus expected to be a good adsorbent candidate for wastewater treatment. The thermodynamic studies evidenced the exothermic character of the adsorption reactions of the studied pollutants.
Thermoelectric Generator Through Dual‐Direction Thermal Regulation by Thermal Diodes for Waste Heat Harvesting
Authors: Li Tian , Jiang Weitao , Tong Yufeng , Jiang Wei , Yin Lei , Chen Bangdao , Shi Yongsheng , Zhang Lei , Liu Hongzhong 
Published: November 2023

AbstractThermal energy harvesting provides an opportunity for multi‐node systems to achieve self‐power autonomy. Thermoelectric generators (TEGs), either by thermocouple arrangement with higher‐aspect‐ratios or thermoelectric films overlay, are limited by the small temperature difference and its short‐duration (less than dozens of minutes), hindering the harvesting efficiency. Here, by introducing thermal diodes with dual‐direction thermal regulation ability to optimize the heat flux path, the proposed TEGs exhibit enhanced power‐supply capability with unprecedented long‐duration (more than hours). In contrast with conventional TEGs with fixed‐leg dimensions enabled single output, these compact‐TEGs can supply up to fourteen output‐channels for selection, the produced power ranges from 1.11 to 921.99 µW, open circuit voltage ranges from 8.07 to 51.32 mV, when the natural temperature difference is 53.84 °C. Compared to the most recent TEGs, the proposed TEGs in this study indicate higher power (more than hundreds times) and much longer output duration (2.4–120 times) in a compact manner.
Title High Solar‐Thermal Conversion Aerogel for Efficient Atmospheric Water Harvesting
Authors: Wang Xiangbing , Ma Guofu , Cui Shuzhen , Sun Kanjun , Li Wenbin , Peng Hui 
Published: November 2023

AbstractThe shortage of freshwater is a global problem, however, the gel that can be used for atmospheric water harvesting (AWH) in recent years studying, suffer from salt leakage, agglomeration, and slow water evaporation efficiency. Herein, a solar‐driven atmospheric water harvesting (SAWH) aerogel is prepared by UV polymerization and freeze‐drying technique, using poly(N‐isopropylacrylamide) (PNIPAm), hydroxypropyl cellulose (HPC), ethanolamine‐decorate LiCl (E‐LiCl) and polyaniline (PANI) as raw materials. The PNIPAm and HPC formed aerogel networks makes the E‐LiCl stably and efficiently loaded, improving the water adsorption‐desorption kinetics, and PANI achieves rapid water vapor evaporation. The aerogel has low density ≈0.12–0.15 g cm−3, but can sustain a weight of 1000 times of its own weight. The synergist of elements and structure gives the aerogel has 0.46–2.95 g g−1 water uptake capability at 30–90% relative humidity, and evaporation rate reaches 1.98 kg m−2 h−1 under 1 sun illumination. In outdoor experiments, 88% of the water is harvesting under natural light irradiation, and an average water harvesting rate of 0.80 gwater gsorbent−1 day−1. Therefore, the aerogel can be used in arid and semi‐arid areas to collect water for plants and animals.
Extraction, Characterization, Antioxidant and Hypoglycemic of Pectic Polysaccharides from Cantaloupe (Cucumis melo L.) Peels
Authors: Sun Hui , Chen Ruizhan , Meng Fanlei , Bai Helong , Tian Li , Lu Juan , Bai Chunlong , Li Dongxue , Wu Wenjing , Wang Yongtang , Gong Mingze 
Published: November 2023

AbstractIn this study, microwave extraction (ME) of pectic polysaccharides (M‐CPPs) from cantaloupe peels (CPs) is optimized using response surface methodology (RSM) with a Box–Behnken design (BBD). The optimum ME parameters are liquid–solid ratio 26.04 mL g−1, microwave power 543.04 W, irradiation time 6.38 min, and pH 1.5. Compared heat reflux extraction polysaccharides (H‐CPPs), the yield, the contents of neutral sugars (TSC), uronic acids (UAC), total flavonoids (TFC), total phenolics (TPC), sulfate groups (SGC) of M‐CPPs increased by 156.06%, 15.33%, 7.27%, 1019.05%, 1.75%, and 57.89%, but the molecular weight (Mw) and degree of esterification (DE) reduced by 29.08% and 24.81%, respectively. M‐CPPs exhibit superior antioxidant and hypoglycemic activities than H‐CPPs, which may be attributed to its higher UAC, TFC and SGC, lower Mw, and DE. There is almost no change in the monosaccharide types of isolated polysaccharides, only a change in molar ratio. Results proved that ME is an efficient technique for the extraction and modification of pectic polysaccharides (CPPs) from CPs with high yield, strong antioxidant, and hypoglycemic activities for applications in medical and food industries.
Investigation of photocatalytic performance of single layer superhydrophilic film: TEOS/PF‐127
Authors: Ramakrishnan Swathi , Jayaraj Shanthi , Ragupathy Chandralekha Nanjan 
Published: November 2023

AbstractMultifunctional antireflective coatings (ARC) have great importance in various applications such as optical devices, flat panel displays, solar cell devices, and so on. Here in this work, highly transparent superhydrophilic film was developed on a cleaned glass substrate by depositing porous TEOS/PF‐127 using the spin coating technique. The coating shows a maximum transparency of 95% in the visible region (400–800 nm). The morphology and porous nature of the prepared sample was analyzed using FESEM and BET analysis respectively. The prepared film exhibited a water contact angle of 9° ensures its superhydrophilic nature. It is also noteworthy that TEOS/PF‐127 coating possesses photocatalytic activity by showing good photo degradation against MB (Methylene Blue) dye under UV‐B (280–315 nm, 50 W) and halogen (340–850 nm, 50 W) light irradiation. The present work provides a simple cost‐effective method to enhance the optical transparency of the glass substrate along with good self‐cleaning properties via photocatalytic activity.
Mapping the extraordinary measure disease outbreak (EMDO): An analysis of health regulations in Indonesia 2000–2023
Authors: Fahadayna Adhi Cahya , Hair Abdul 
Published: November 2023

AbstractThis research focused on the Indonesian Government's global pandemic policy mapping from 2000 to 2023 (n = 979). Indonesia has been affected by diseases such as H1N1, H5N1, SARS‐Cov‐1, and the current SARS‐CoV‐2 (COVID‐19). This research will focus on these outbreaks to see the readiness of Indonesian government policy mapping to emergencies. This research will measure Indonesian health policy mapping based on its capability to adapt to local contexts, construct a care delivery value chain, leverage shared delivery infrastructure, and improve health delivery and economic development. This study implemented feasibility analysis with a method scoring system for all the pillars above. Findings indicate that most health policies developed by the Indonesian Government are oriented toward responding to current conditions, not preparing for future health challenges. This research also provides patterns regarding the development of health policymaking to deal with emergency conditions.
Phase space renormalization and finite BMS charges in six dimensions
Authors: Capone Federico , Mitra Prahar , Poole Aaron , Tomova Bilyana 
Published: November 2023

Abstract
We perform a complete and systematic analysis of the solution space of six-dimensional Einstein gravity. We show that a particular subclass of solutions — those that are analytic near $$ \mathcal{I} $$
I
+ — admit a non-trivial action of the generalised Bondi-Metzner-van der Burg-Sachs (GBMS) group which contains infinite-dimensional supertranslations and superrotations. The latter consists of all smooth volume-preserving Diff×Weyl transformations of the celestial S4. Using the covariant phase space formalism and a new technique which we develop in this paper (phase space renormalization), we are able to renormalize the symplectic potential using counterterms which are local and covariant. The Hamiltonian charges corresponding to GBMS diffeomorphisms are non-integrable. We show that the integrable part of these charges faithfully represent the GBMS algebra and in doing so, settle a long-standing open question regarding the existence of infinite-dimensional asymptotic symmetries in higher even dimensional non-linear gravity. Finally, we show that the semi-classical Ward identities for supertranslations and superrotations are precisely the leading and subleading soft-graviton theorems respectively.
Surface Houghton groups
Authors: Aramayona Javier , Bux Kai-Uwe , Kim Heejoung , Leininger Christopher J. 
Published: November 2023

AbstractFor every $$n\ge 2$$

n
≥
2

, the surface Houghton group$${\mathcal {B}}_n$$

B
n

is defined as the asymptotically rigid mapping class group of a surface with exactly n ends, all of them non-planar. The groups $${\mathcal {B}}_n$$

B
n

are analogous to, and in fact contain, the braided Houghton groups. These groups also arise naturally in topology: every monodromy homeomorphism of a fibered component of a depth-1 foliation of closed 3-manifold is conjugate into some $${\mathcal {B}}_n$$

B
n

. As countable mapping class groups of infinite type surfaces, the groups $$\mathcal {B}_n$$

B
n

lie somewhere between classical mapping class groups and big mapping class groups. We initiate the study of surface Houghton groups proving, among other things, that $$\mathcal {B}_n$$

B
n

is of type $$\text {F}_{n-1}$$

F

n
-
1

, but not of type $$\text {FP}_{n}$$

FP
n

, analogous to the braided Houghton groups.
Reporting of adverse events of treatment interventions in multiple myeloma: an overview of systematic reviews
Authors: Mainou Maria , Bougioukas Konstantinos I. , Malandris Konstantinos , Liakos Aris , Klonizakis Philippos , Avgerinos Ioannis , Haidich Anna-Betinna , Tsapas Apostolos 
Published: November 2023

AbstractThe present study is an overview of systematic reviews focusing on adverse events of antimyeloma treatments. It provides a systematic description of adverse events as they are reported in the systematic reviews as well as a critical appraisal of included reviews. We conducted a comprehensive literature search in the most widely used electronic databases looking for systematic reviews that had an adverse event of an antimyeloma treatment intervention as primary outcome. Two independent reviewers conducted selection of included studies and data extraction on predesigned online forms and assessed study quality using AMSTAR 2. Overall corrected covered area (CCA) was calculated to examine the overlap of primary studies across systematic reviews. After screening eligible studies, 23 systematic reviews were included in this overview. Seven reviews with overall CCA of 14.7% examined cardiovascular adverse events of different drugs, including immunomodulatory drugs and proteasome inhibitors (mainly carfilzomib). Nine focused on infections, presenting with overall CCA of 5.8%, each one focused on a different drug or drug class. Three studied thromboembolism in patients treated either with lenalidomide, any immunomodulatory drug, or with daratumumab and had an overall CCA equal to 1.5%. Four more reviews focused on bortezomib-associated neurotoxicity, carfilzomib-associated renal toxicity, or second primary malignancies as an adverse event of lenalidomide or anti-CD38 monoclonal antibody treatment. The quality of included studies as judged by AMSTAR 2 was mostly critically low. Absence of a priori registered protocol and formal assessment of risk of bias of included primary studies were the most common shortcomings. Reporting of antimyeloma drug-associated toxicity is supported by multiple systematic reviews; nevertheless, methodological quality of existing reviews is mostly low.