bluuebunny/crossref_metadata_2025_split huggingface dataset:
High body-mass index a risk factor for colon and rectal cancer in Asia during 1990 to 2019: a cross-national study
Authors: Goodarzi Elham , Ghaderi Mahtab , Madadi Zahra , Ghiasi Ali , Azizi Mehrshad , Fazeli Tayebeh 
Published: February 2024

Abstract

Background:
Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer-related mortality. Epidemiological evidence consistently establishes a correlation between obesity and colorectal cancer. The study aims to examine the prevalence of colorectal cancer in relation to high body mass index (BMI) across Asian countries.
Methods:
This population-based study utilized epidemiological data on colorectal cancer attributed to high BMI sourced from the Global Burden of Diseases (GBD) 2019 database. The data encompassed deaths, disability-adjusted life years (DALYs), and age-standardized rates, stratified by gender and country within the Asian continent. We assessed trends in mortality and DALYs from 1990 to 2019. Additionally, Pearson correlation analysis explored the association between Socio-Demographic Index (SDI) and the burden of colon and rectal cancer attributable to high BMI.
Results:
Asia documented the highest DALY attributed to high BMI, reaching 774.9 per 1000. Notably, death rates and DALYs associated with high BMI exhibited an upward trajectory with age. Vietnam (557.9%) and Nepal (367.6%) demonstrated the highest percentage changes in age-standardized mortality rates (ASMR) from 1990 to 2019, while Vietnam (556.73%) and Indonesia (354.91%) led in age-standardized death rates (ASDR) changes. Results underscored a substantial increase in ASMR and ASDR attributed to high BMI in the Asian continent from 1990 to 2019, predominantly among men. Furthermore, we established a positive and significant correlation between ASMR and high BMI (r=0.72, p-value<0.0001).
Conclusion:
Given the observed rise in mortality and DALYs associated with colon and rectal cancer attributed to high BMI, particularly among men in developed countries, intervention measures aimed at mitigating this burden are imperative. This study highlights the urgency of implementing targeted interventions to reduce the impact of high BMI on colorectal cancer mortality and overall disease burden.
Acid-catalyzed transformation of orange waste into furfural: the effect of pectin degree of esterification
Authors: Rivera-Cedillo Eva Estela , González-Chávez Marco Martin , Handy Brent Edward , Quintana-Olivera Maria-Fernanda , López-Mercado Gloria Janneth , Galindo María Guadalupe Cárdenas 
Published: February 2024

Abstract
The transformation of biomasses from agro-industrial waste can significantly impact the production of green chemicals from sustainable resources. Pectin is a biopolymer present in lignocellulosic biomass as Orange Peel Waste (OPW), and has possibilities for making platform compounds such as furfural for sustainable chemistry. In this work, we studied the transformation to furfural of OPW, pectins, and D-galacturonic acid (D-GalA), which is the main component of pectin. We analyzed pectins with different degrees of esterification (DE) in a one-pot hydrolysis reaction system and studied the differences in depolymerization and dehydration of the carbohydrates. The results show that the production of furfural decreases as the DE value increases. Specifically, low DE values favor the formation of furfural since the decarboxylation reaction is favored over deesterification. Interestingly, the furfural concentration is dependent upon the polysaccharide composition of pentoses and uronic acid. The obtained concentrations of furfural, D-xylose, and L-arabinose remained the same when the galacturonic acid was fed either as a polymer or a monomer. OPW is proposed as a feedstock in a biorefinery, in which on a per kg OPW dry basis, 90 g of pectin and 15 g of furfural are produced in the most favorable case. We conclude that the co-production of pectin and furfural from OPW is economically feasible.
Impact of universal hepatitis B virus (HBV) screening using chemotherapy orders on the HBV reactivation in cancer patients
Authors: Marty Céline , Adam Jean-Philippe , Martel-Laferrière Valérie , Doucet Stéphane , Martel Dominic 
Published: February 2024

Abstract

Introduction
Hepatitis B virus (HBV) reactivation (HBVr) induced by chemotherapy in patients with resolved or chronic infection can lead to severe consequences. Despite recommendations, rates of HBV screening before chemotherapy are low due to poor recognition of risk factors by clinicians. The aim of the study is to assess whether routine HBV screening using universal HBV screening on chemotherapy orders (CO) could reduce HBVr incidence.
Methods
This is a one-year retrospective single-center observational study of patients who received intravenous chemotherapy post implementation of CO. We compared the incidence of HBVr in three groups of patients: those screened through CO (group 1), those screened by the medical team (group 2) and those not screened (group 3).
Results
On a total of 1374 patients, 179 of 206 patients were screened as requested on CO (group 1) and 421 by the medical team (group 2), whereas 747 patients were not screened (group 3). Only 1 HBVr occurred, and no difference was seen on the incidence of HBVr between group 1 and group 3 (0% vs 0.1%; p=1.00), probably because of a lack of follow‑up after chemotherapy. Follow‑up for HBVr was imperfect in group 1 and group 2 (16.7% vs 5.6%; p=0.32). Screening was done for 92% of patients on anti‑CD20 therapy. In group 3, 89 patients had ALT elevation during chemotherapy but only 17 (19%) were tested for HBVr.
Conclusion
Universal HBV screening on CO is useful to implement HBV detection and can help to prevent HBVr. Nevertheless, this screening method do not guarantee optimal follow‑up and requires improvements.
Uncovering Causal Associations of Immune Cells with Rheumatoid Arthritis: A Mendelian Randomization Study
Authors: 王 淑娴 , Su Sensen , Zhang Deyou , Pan Tingting , Wu Hao 
Published: February 2024

Abstract
Background
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by progressive joint damage and functional limitations, often accompanied by comorbidities. While the impact of immune cells on the development of RA is recognized, the precise causal relationships with various immunophenotypes are yet to be fully understood.
Methods
We performed a comprehensive two-sample Mendelian randomization (MR) study to explore the associations between immunophenotypes and RA. Utilizing publicly available genetic datasets, we examined causal links involving 731 immune cell traits, categorized into four groups: relative cell counts (RC), median fluorescence intensities (MFI), morphological parameters (MP), and absolute cell counts (AC). Extensive sensitivity analyses were carried out to validate the robustness of our results. These analyses aimed to assess heterogeneity and investigate the potential influence of horizontal pleiotropy.
Results
After applying FDR correction, two specific immunophenotypes were found to be associated with RA: CD33dim HLA-DR + CD11b+ %CD33dim HLA-DR + and CD33dimHLA-DR + CD11b-%CD33dimHLA-DR+. The odds ratios (ORs) for RA risk forthese immunophenotypes, calculated using the inverse variance weighting(IVW) method, were 0.970 (95% CI = 0.955–0.985, P = 1.09×10− 4, PFDR = 0.058) and 1.027 (95% CI = 1.011–1.042, P = 5.05×10− 4, PFDR = 0.074), respectively. In contrast, without FDR correction, six additional immunophenotypes showed significant associations with RA: CD14 on CD33dim HLA-DR + CD11b+, CD16 on CD14 + CD16 + monocytes, CD11b on basophils, CD3 on TD CD4+, PDL-1 on CD14- CD16 + monocytes, and CD4 on HLA-DR + CD4+. Of these, the first two were linked to increased RA risk, while the latter four exhibited protective characteristics.
Conclusions
This study highlights a strong genetic link between immune cell profiles and RA, illuminating potential targets for innovative therapeutic strategies.
Successful treatment of severe renal failure caused by malignant hypertension using a combination of renin-angiotensin-aldosterone system inhibitors: a case report
Authors: Harada Wataru , Maeoka Yujiro , Takahashi Akira , Yoshida Mahoko , Osaki Yosuke , Ishiuchi Naoki , Sasaki Kensuke , Masaki Takao 
Published: February 2024

Abstract
Background: Marked activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role in hypertensive emergencies, in particular malignant hypertension, by worsening hypertension and renal function. The rates of readmission for severe hypertension and cardiovascular disease in such emergencies are high, suggesting that suppression of the RAAS may be not adequate during the acute phase in some cases. Although treatment with a combination of RAAS inhibitors decreases blood pressure (BP) to a greater extent than monotherapy, its specific impact on malignant hypertension has not been reported.
Case presentation: A 41-year-old woman presented with malignant hypertension complicated with renal insufficiency (creatinine 3.93 mg/dL) and massive proteinuria (4.0 g/day). Renal biopsy confirmed malignant nephrosclerosis and thrombotic microangiopathy. Antihypertensive therapy was administered, including an angiotensin receptor blocker (ARB), aliskiren (a direct renin inhibitor), and spironolactone, a nonselective mineralocorticoid receptor antagonist, which preserved renal function effectively and normalized BP. Plasma renin activity was extremely high (131.9 ng/mL/h) on admission but normalized within almost 2 weeks after initiation of antihypertensive treatment. Although aliskiren and spironolactone were discontinued before discharge, BP was well controlled and renal function was further improved (creatinine 1.14 mg/dL) at follow-up 24 months after discharge.
Discussion: This case of renal failure induced by malignant hypertension was successfully treated with a combination of RAAS inhibitors (i.e., a direct renin inhibitor, an angiotensin receptor blocker, and a nonselective mineralocorticoid receptor antagonist). The controlled BP and improved renal function during both the short term and long term in this patient suggest that adequate suppression of the RAAS cascade during the acute phase of malignant hypertension is potentially effective in terms of breaking the vicious circle of malignant hypertension and hyperreninemia.
Service Quality Optimization in Entrepreneurial Ventures: A Sustainable Approach Amidst Inflation and Price Hike
Authors: Gupta Reena 
Published: February 2024

Abstract
This research explores the nuanced landscape of service quality optimization in entrepreneurial ventures amid the challenges posed by inflation and price hikes. The study employs a qualitative approach, utilizing in-depth interviews and focus group discussions with entrepreneurs from diverse industries. Through a thematic analysis, the findings shed light on the dynamic strategies employed by entrepreneurs to adapt and thrive in the face of economic uncertainties. Entrepreneurs universally recognize the substantial impact of inflation and price hikes on their ventures. The rise in operational costs, particularly in raw materials, energy, and labor, poses significant challenges to profit margins. However, the study unveils a remarkable capacity for adaptation and resilience among entrepreneurs. Flexibility in pricing strategies, exploration of alternative suppliers, and continuous reassessment of business models emerge as common adaptive responses. Technological innovation emerges as a key theme, with entrepreneurs leveraging automation, artificial intelligence, and digital platforms to enhance operational efficiency and maintain service quality. Customer-centric approaches remain paramount, emphasizing the importance of understanding and meeting customer expectations transparently. A notable finding is the integration of sustainable practices as a strategic response. Entrepreneurs increasingly adopt environmentally friendly and socially responsible business practices, recognizing sustainability not only as a moral imperative but also as a source of differentiation and long-term resilience. Emotional intelligence in leadership, collaboration, and strategic pricing also feature prominently in the findings. Effective leadership, collaborative networks, and strategic pricing strategies are identified as crucial elements in navigating the intricate challenges posed by economic uncertainties. Despite the positive strategies employed, entrepreneurs identify challenges to sustaining entrepreneurship, including access to capital, regulatory hurdles, and the need for a supportive policy environment. The study concludes by highlighting the broader implications of the findings for theory, practice, and policy, offering valuable insights for entrepreneurs, policymakers, and researchers navigating the complex terrain of service quality optimization in entrepreneurial ventures amid economic uncertainties.
Ground vibration and air overpressure prediction applied to a blasting operation in a Gneiss quarry in southern Brazil
Authors: Lima Key Fonseca , Meireles Anderson da Cunha , Barbieri Nilson , Fiorentin Luan Demarco 
Published: February 2024

Abstract
Explosives are applied as a mining tools where mechanical processes are not applicable or economically feasible. The proximity and coexistence of these blasting processes with housing units present a problem in the operational context. Part of the non-absorbed energy from the rock blasting causes vibration and noise that propagated through the ground or the atmosphere, which can cause distress to the people living or working nearby. A methodology was proposed to predict the physical parameters resulting from the effects of ground vibration (PPV) and air overpressure (AOp) in safe blasting operations in a Gneiss open-pit mine in the South of Brazil. An engineering seismograph monitored shock waves for 31 detonations over three years. The seismograph reports obtained were evaluated using SPSS Statistics IBM 25 and Microsoft Excel 2016, to develop the multiple linear regression (MLR) models, and GeneXproTools 5.0 to build the shock wave prediction model using Gene Expression Programing (GEP). Based on the computational analysis was possible to create two methods of analysis and two computational models to predict shock waves: MLR and GEP. Through the performance analysis, the model obtained from the GEP proved to be more effective and assertive for predicting PPV and AOp.
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
Authors: 李 双 , Yang Lina , Ding Xiaoyan , Sun Hongxiao , Dong Xiaolei , Yang Fanghao , Wang Mengjun , Zhang Huhu , Li Ya , Li Bing , Liu Chunyan 
Published: February 2024

Abstract
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our research, USP32 was strongly expressed in NSCLC cell lines and tissues and was linked to a bad prognosis for NSCLC patients. Interference with USP32 resulted in a significant inhibition of NSCLC cell proliferation, migration potential, and EMT development; on the other hand, USP32 overexpression had the opposite effect. To further elucidate the mechanism of action of USP32 in NSCLC, we screened H1299 cells for interacting proteins and found that USP32 interacts with BAG3 (Bcl2-associated athanogene 3) and deubiquitinates and stabilizes BAG3 in a deubiquitinating activity-dependent manner. Functionally, restoration of BAG3 expression abrogated the antitumor effects of USP32 silencing. Furthermore, USP32 increased the phosphorylation level of the RAF/MEK/ERK signaling pathway in NSCLC cells by stabilizing BAG3. In summary, these findings imply that USP32 is critical to the development of NSCLC and could offer a theoretical framework for the clinical diagnosis and management of NSCLC patients in the future.
Functional morphology of the Dufour gland in the queenless ant Dinoponera quadriceps
Authors: Billen Johan , Monnin Thibaud 
Published: February 2024

Abstract

Colonies of the queenless ponerine antDinoponera quadricepsare characterized by a social hierarchy among the workers, in which the gamergate occupies the alpha rank. She may be challenged, however, by a beta worker in an attempt to take over reproductive control in the colony. The gamergate does not engage in a direct conflict, however, but only smears secretion from her Dufour gland onto the beta worker. This secretion then stimulates the low-ranked workers to immobilize the beta worker and thus prevent it from overthrowing the gamergate. Our histological and ultrastructural examination of the Dufour gland in gamergates, one-week-old workers and low-ranked foragers clearly shows that the gamergate has the most developed gland containing an abundant smooth endoplasmic reticulum and an obvious microvillar differentiation of the apical cell membrane. These findings are in line with the already existing chemical and behavioural observations of the peculiar pretender punishment in this species.
Interaction of AURKA with TRIM28 revives dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis
Authors: Yang Liyun , Geng Liang , Zhang Xinxin , zhao runyu , Qiao Peipei , Zhang Hao , Wu Geping 
Published: February 2024

Abstract

Background
Specific molecular mechanisms by which AURKA promoted LSCC metastasis were still unknown.
Methods
Bioinformatic analysis was performed the relationship between TRIM28 and LSCC. Immunohistochemistry, Co-IP assay, Rt-PCR and Western Blot were used to examine the expression of related molecular. Flow cytometry was used to examine cell numbers of G0/G1 phase. Plate colony formation, wound healing, migration, invasion and tail vein injection in nude mice assays were applied to examine the proliferation, movement, migration, invasion and metastasis of LSCC.
Results
TRIM28 was significantly correlated with LSCC. TRIM28 highly expressed in LSCC and the high TRIM28 expression was related to TNM stage and poor clinical prognosis. Furthermore, AURKA could regulate TRIM28. In addition, deprivation TRIM28 expression induced LSCC cells into dormant state and inhibited LSCC metastasis. Akt signaling pathway played an essential role in promoting the tumor-promoting effects induced by TRIM28.
Conclusion
AURKA mediated TRIM28 to revive dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis, targeting TRIM28 might provide a potential treatment strategy for LSCC.
Bibliometric analysis of emerging trends and research foci in brainstem tumor field over thirty years (1992-2023)
Authors: Geng Yibo , Xie Luyang , Li Jinping , Wang Yang , Li Xiong 
Published: February 2024

Abstract
Purpose: Over the past several decades, numerous articles have been published on brainstem tumors. However, there has been limited bibliometric analysis in this field. Therefore, we conducted a bibliometric analysis to elucidate the evolution and current status of brainstem tumor research.
Methods: We retrieved 5,525 studies published in English between 1992 and 2023 from the Web of Science Core Collection database. We employed bibliometric tools and VOSviewer to conduct the analysis.
Results: We included a total of 5,525 publications for further analysis. The annual publications has exhibited steady growth over time. The United States accounted for the highest number of publications and total citations. Among individual researchers, Liwei Zhang had the highest number of publications, while Eric Bouffet received the most citations in this field. The study titled "Somatic Histone H3 Alterations in Pediatric Diffuse Intrinsic Pontine Gliomas and Non-brainstem Glioblastomas" stood out as the most cited work in this field. Keyword analysis revealed that immune therapy and epigenetic research are the focal points of this field.
Conclusions: Our bibliometric analysis underscores the enduring significance of brainstem tumors in the realm of neuro-oncology research. The field's hotspots have transitioned from surgery and radiochemotherapy to investigating epigenetic mechanisms and immune therapy.
Puerarin rescued Dex-induced Osteoblast Apoptosis via AIF-mediated Caspase-independent pathway
Authors: Yu Dongdong , Qiao Ye , Chen Haoran , Gu Haili , Qiao Long 
Published: February 2024

Abstract
GIOP is the most common secondary osteoporosis, and the increased apoptosis of osteoblasts is thought to be the main cause of GIOP. Puerarin is the major isoflavone extracted from Pueraria lobata. Our previous study indicated that Puerarin protects osteoblast apoptosis partly through the caspase-dependent pathway. So, we concluded that there existed other anti-apoptotic mechanisms in Puerarin. Therefore, in the current study, we focused on the role of the caspase-independent pathway, specifically the apoptosis-inducing factor (AIF) pathway. MTS assay, flow cytometry, TUNEL staining, Western blotting, and immunofluorescence staining were used in this study. Caspase inhibitor Z-VAD-FMK and RNA silencing (siRNA) AIF were used to assist Puerarin in detecting the anti-apoptosis mechanisms. The results showed that Puerarin significantly alleviated Dex-induced osteoblast cell proliferation inhibition and cell cycle arrest at G0/G1 phase. Puerarin can restore the protein expression of cell cycle-related proteins (cyclin D1) and cyclin-dependent kinase (CDK4). Flow cytometry and TUNEL staining revealed that the pan-caspase inhibitor Z-VAD-FMK and siRNA AIF partially inhibited Dex-induced osteoblast apoptosis, while Puerarin significantly reduced Dex-induced osteoblast cell apoptosis. Immunofluorescence and Western blotting results showed that nucleus translocation of AIF from mitochondria in Dex-treated cells also inhibited by Puerarin. Our results suggest that Puerarin can restore Dex-induced cell cycle inhibition and apoptosis of osteoblasts through the AIF-regulated caspase-independent pathway.
Formulation and Evaluation of Controlled Release Matrix Tablets of Selexipag
Authors: SRI M. , G.S.Valluri  , G.VIJAYKUMAR  
Published: February 2024

Abstract
The objective of the present study was to develop a Controlled release matrix tablets of Selexipag, an anti hypertensive drug. The Controlled release tablets were prepared by wet granulation and formulated using different drug and polymer ratios, formulations such as F1 to F9. Hydrophilic polymer like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer like Ethyl Cellulose(EC) and natural polymer like Xanthan Gum(XG) were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. The optimized formulation(F3) on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and friability. All tablets but one exhibited gradual and near completion Controlled release for Selexipag, and 96.45% released at the end of 10h. The results of dissolution studies indicated that formulation F3 (drug to polymer 1:1.5), the most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer ratio. Applying exponential equation, all the formulation tablets(except F3) showed diffusion-dominated drug release. The mechanism of drug release from F3 was diffusion coupled with erosion.