bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tobacco product flavour policies in the USA
Authors: Whitacre Travis R , Crippen Alyssa , Monthrope Mayah , Narine Tanisha , Liber Alex C , Friedman Abigail S 
Published: January 2025

ObjectivesCharacterise US residents’ exposure to restrictions on sales of flavoured electronic nicotine delivery system (ENDS), cigars and menthol cigarettes across states and time, and assess correlations between these policies.MethodsFrom 2022 to 2024, we compiled flavour policy locations from advocacy groups and online searches, located corresponding legal texts and reviewed these to identify policy details, including effective dates. Using census data, we calculated the proportion of state residents covered by each policy quarterly from 2009 to 2024 and estimated correlations between them and cigarette taxes.ResultsBy January 2024, menthol cigarettes, flavoured cigars and flavoured ENDS sales restrictions covered 17.6%, 18.1% and 28.1% of US residents. About 1 in 10 US residents is subject to flavoured ENDS restrictions without concurrent restrictions on flavoured cigar and menthol cigarette sales. Strong correlations between flavour policy coverage and cigarette tax rates indicate a need to adjust for exposure to a range of tobacco control policies in analyses evaluating any one of these regulations’ effects.ConclusionsWhile state and local adoption of restrictions on flavoured tobacco product sales has proliferated, flavour policy coverage for combustible tobacco products lags well behind that for ENDS. If this leads some people who vape flavoured ENDS to substitute towards flavoured cigars and/or menthol cigarettes, this policy combination could harm population health.Policy implicationsRapid implementation of proposed US Food and Drug Administration rules barring flavoured cigar and menthol cigarette sales is needed to ensure that regulation of more lethal, combustible tobacco products is not more lenient than restrictions on less harmful nicotine products.
Psychological, social and cultural influences on smoking among lesbian, bisexual and queer women
Authors: Grant Ruby , Mooney-Somers Julie , McNair Ruth , Pennay Amy , Segan Catherine , Power Jennifer , Bourne Adam 
Published: January 2025

BackgroundSmoking rates have declined markedly in Australia over time; however, lesbian, bisexual and queer (LBQ) women continue to smoke at higher rates than heterosexual women. Understanding the factors influencing smoking in this population is crucial for developing targeted cessation interventions and other supports.MethodsExperiences of and motivations for smoking among 42 LBQ cisgender and transgender women and non-binary people in Australia who currently or previously smoked were explored through semi-structured interviews. Participants were primarily white Australian cisgender women in their 30s–40s. Thematic analysis was used to identify common psychological, social and cultural influences on smoking.ResultsWhile coping with minority stress was a common factor influencing some participants’ smoking behaviours, participants also described how smoking offered pleasurable opportunities for gender expression, affirmation and rebellion. Smoking also enabled participants to experience ‘marginalised connectivity’, a form of social solidarity fostered through the sharing of a stigmatised practice by an oppressed or stigmatised community.ConclusionThis article identifies factors contributing to the ongoing socio-cultural relevance of smoking for some LBQ women in Australia. These specific psychological, social and cultural contexts remain salient for LBQ women’s smoking and must be factored into smoking cessation campaigns and programme designs for this population. Tailored messaging that emphasises alternative self-care strategies and the benefits of quitting in the context of supportive communities may be more effective in engaging LBQ women than long-term health risk messages.
RA-MOSAIC
: Resource Adaptive Edge AI Optimization over Spatially Multiplexed Video Streams
Authors: Gokarn Ila , Hu Yigong , Abdelzaher Tarek , Misra Archan 
Published: January 2025

Sustaining real-time, high fidelity AI-based vision perception on edge devices is challenging due to both the high computational overhead of increasingly “deeper” Deep Neural Networks (DNNs) and the increasing resolution/quality of camera sensors. Such high-throughput vision perception is even more challenging in multi-tenancy systems, where video streams from multiple such high-quality cameras need to share the same GPU resource on a single edge device. Criticality-aware
canvas-based processing
is a promising paradigm that decomposes
multiple concurrent
video streams into Regions of Interest (RoI) and spatially channels the limited computational resources to selected RoI with higher “resolution”, thereby moderating the trade-off between computational load, task fidelity, and processing throughput.
RA-MOSAIC (Resource Adaptive MOSAIC)
employs such canvas-based processing, while further tuning the incoming video streams and available resources on-demand to allow the system to adapt to dynamic changes in workload (often arising from variations in the number or size of relevant objects observed by individual cameras).
RA-MOSAIC
utilizes two distinct and synergistic concepts. First, at the camera sensor, a
bandwidth-adaptive
and lightweight Bandwidth Aware Camera Transmission (BACT) method applies differential down-sampling to create mixed-resolution individual frames that preferentially preserve resolution for critical ROIs, before being transmitted to the edge node. Second, at the edge, BACT video streams received from multiple cameras are decomposed into multi-scale RoI tiles and spatially packed using a novel
workload-adaptive
bin-packing strategy into a single ‘canvas frame’. Notably, the canvas frame itself is dynamically sized such that the edge device can opportunistically provide higher processing throughput for selected high-priority tiles during periods of lower aggregate workloads. To demonstrate
RA-MOSAIC’s
gains in processing throughput and perception fidelity, we evaluate
RA-MOSAIC
on a single NVIDIA Jetson TX2 edge device for two benchmark tasks: Drone-based Pedestrian Detection and Automatic License Plate Recognition. In a bandwidth-constrained wireless environment,
RA-MOSAIC
employs a batch size of 1 to pack up to 6 concurrent video streams on a dynamically sized canvas frame to provide (i) 14.3% gain in object detection accuracy and (ii) 11.11% gain in throughput on average (up to 20 FPS per camera, cumulatively 120 FPS), over our previous work MOSAIC, a naïve canvas-based baseline. Compared to prior state of the art baselines such as batched inference over extracted RoI,
RA-MOSAIC
provides a very-significant, 29.6% gain in accuracy for a comparable throughput. Similarly,
RA-MOSAIC
dramatically outperforms bandwidth adaptive baselines, such as FCFS (

\(\leq 1\%\)

accuracy gain but

\(5.6\)

x or 566.67% throughput gain) and uniform grid packing (17% accuracy improvement and 5% throughput gain).
LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
Authors: Martires Lauren Catherine M. , Ahronian Leanne G. , Pratt Charlotte B. , Das Nikitha M. , Zhang Xiaobin , Whittington Douglas A. , Zhang Hongxiang , Shen Binzhang , Come Jon , McCarren Patrick , Liu Mu-Sen , Min Chengyin , Feng Tianshu , Jahic Haris , Ali Janid A. , Aird Daniel R. , Li Fang , Andersen Jannik N. , Huang Alan , Mallender William D. , Nicholson Hilary E. 
Published: January 2025

Abstract
Synthetic lethality approaches in BRCA1/2-mutated cancers have focused on PARP inhibitors, which are subject to high rates of innate or acquired resistance in patients. In this study, we used CRISPR/Cas9-based screening to identify DNA ligase I (LIG1) as a novel target for synthetic lethality in BRCA1-mutated cancers. Publicly available data supported LIG1 hyperdependence of BRCA1 mutant cells across a variety of breast and ovarian cancer cell lines. We used CRISPRn, CRISPRi, RNAi, and protein degradation to confirm the lethal effect of LIG1 inactivation at the DNA, RNA, and protein level in BRCA1 mutant cells in vitro. LIG1 inactivation resulted in viability loss across multiple BRCA1-mutated cell lines, whereas no effect was observed in BRCA1/2 wild-type cell lines, demonstrating target selectivity for the BRCA1 mutant context. On-target nature of the phenotype was demonstrated through rescue of viability with exogenous wild-type LIG1 cDNA. Next, we demonstrated a concentration-dependent relationship of LIG1 protein expression and BRCA1 mutant cell viability using a titratable, degradable LIG1 fusion protein. BRCA1 mutant viability required LIG1 catalytic activity, as catalytically dead mutant LIG1K568A failed to rescue viability loss caused by endogenous LIG1 depletion. LIG1 perturbation produced proportional increases in PAR staining in BRCA1 mutant cells, indicating a mechanism consistent with the function of LIG1 in sealing ssDNA nicks. Finally, we confirmed LIG1 hyperdependence in vivo using a xenograft model in which LIG1 loss resulted in tumor stasis in all mice. Our cumulative findings demonstrate that LIG1 is a promising synthetic lethal target for development in patients with BRCA1-mutant cancers.
Assessing Knowledge Claims in Scientific Controversies: On the Origins of COVID-19
Authors: Panagiotou Aristeidis 
Published: January 2025

Abstract
In the field of Science and Technology Studies (STS), scientific controversies (SCs) are often viewed as essential steps in the development of knowledge and technoscientific artifacts. This paper addresses the lack of an orchestrated epistemological effort to assess the quality of knowledge claims (KCs) articulated during SCs. This study proposes a framework that bridges ontology with appropriate methodological techniques to evaluate KCs, considering them as ontological hybrids in which the social and epistemic are interwoven. This paper argues for the rehabilitation of the existential autonomy of the natural world, which has been overshadowed by an overreaction to positivism. By employing methodological bracketing, specifically that of positive and normative analyses, this study aims to assess KCs in terms of their proximity to intransitive reality and the socio-political dynamics that influence their emergence respectively. The second part of the paper applies this framework to the SC on the origins of the COVID-19 pandemic, suggesting a nuanced understanding that goes beyond the dichotomy of zoonosis and genetic engineering. This study highlights the impact of social factors on scientists’ epistemic stances, and the importance of public deliberation in policy formation. The contributions of this study are both epistemological and policy-oriented.
Three-Plane Calcaneal Osteotomy With Joint Preservation vs Subtalar Arthrodesis to Treat Painful Calcaneal Fracture Malunions
Authors: Feng Hui , Ji Dong-Dong , Yang Xin-Quan , Yue Yang , Wang Zhe , Zhang Yan , Liu Pei-Long , Liang Jing-Qi , Zhao Hong-Mou 
Published: January 2025

Background: Calcaneal fracture malunion (CFM) commonly occurs with multiple pathologic changes and progressive pain and difficulty walking. The purpose of this study was to propose a modified 3-plane joint-preserving osteotomy for the treatment of CFM with subtalar joint incongruence, and to compare its efficacy to subtalar arthrodesis. Methods: A retrospective comparative analysis of the data of 56 patients with CFM admitted from January 2017 to December 2022 was performed. Twenty-six patients were in the osteotomy group and 30 in the arthrodesis group. Computed tomographic (CT) scans were used for measurement of the intraarticular steps. Radiologic parameters, visual analog scale (VAS) score for pain, 12-Item Short Form Health Survey (SF-12) mental component summary (MCS) and physical component summary (PCS) scores were compared between the 2 groups of patients to assess the outcome preoperatively and at last follow-up, which averaged 22.6 ± 3.6 months and 27.6 ± 3.6 months for the osteotomy and arthrodesis groups, respectively. Results: Improvements in pain, function, and overall quality of life were obtained in both groups compared with the preoperative values at last follow-up. The VAS and SF-12 scores were similar between the groups at the last follow-up. In the osteotomy group, the average CT scan–measured intraarticular step-offs were significantly reduced from 3.7 ± 1.2 mm to 0.9 ± 0.3 mm. The osteotomy group showed improvement in pronation and supination range of motion (ROM) of the feet ( P < .01). The correction of the ankle height and Meary angle were slightly better in the osteotomy group. Conclusion: In this short-term follow-up study, good results were achieved in both joint-preserving osteotomy and subtalar arthrodesis groups for the treatment of CFM with subtalar joint incongruence. The osteotomy group preserved the subtalar joint and achieved improvements in pronation and supination ROM.
Neonatal inpatient stays longer than one year: Who was admitted, what happened, and how much did it cost?
Authors: Shah Nihaal , Sunny Angel , Dapaah-Siakwan Fredrick 
Published: January 2025

Background Anecdotal evidence suggests that some preterm infants remain hospitalized for more than a year, but little is known about this population. We aimed to describe the characteristics, the hospital course, and the hospital costs for preterm hospitalizations with length of stay (LOS) ≥365 days. Methods This was a retrospective, descriptive cohort study of the 2016 and 2019 Kids Inpatient Database. ICD-10 codes were used to identify preterm infants, their comorbidities, and surgical interventions. The study population was dichotomized into LOS ≤364 days (PT364) and LOS ≥365 days (PT365) and compared using Chi-square or Mann-Whitney U test as appropriate. The exposure was PT365, and the outcomes were the characteristics, comorbidities, discharge disposition, and inflation-adjusted hospital costs. Results Among 688,995 preterm infants, 111 had LOS ≥365 days (0.016%). Compared to PT364, PT365 were more likely to be males (74.6% vs 53.2%), of gestational age ≤27 weeks (71.5% vs 4.7%), and <1000 gm birthweight (64.2% vs 4.0%). PT365 were more likely to have a higher prevalence of comorbidities in each organ system, surgical and procedural interventions, and neonatal chronic complex conditions (872% vs 13.3%). PT365 were less likely to be discharged home (45.7% vs 93.4%) and more likely to be discharged to home healthcare (28.0% vs 5.7%) or to a skilled nursing facility (16.0% vs 0.8). The median hospital cost per surviving PT365 was $1,616,336. Conclusion PT365 was rare but was associated with complex chronic conditions, increased morbidity and surgical burden, and high inflation-adjusted hospital costs.
Long-term sublingual bacterial immunotherapy prevents ear, nose and throat infections: A real-life study
Authors: Aarestrup Paula F , Aarestrup Matheus F , JV Aarestrup Beatriz , Cheloni Edir P , Aarestrup Fernando M 
Published: January 2025

Objective: Bacterial extracts have been used for many years to prevent airway infections. Recent findings suggest that immunity can be trained by inducing an immunological memory in both the innate and acquired immune response. This real-life observational study investigated the potential of sublingual bacterial immunotherapy in the prevention of ear, nose, and throat infections. Methods: Patients received sublingual bacterial immunotherapy for 12 months and were followed for 24 months. The number of ear, nose, and throat infection episodes from the previous year was recorded during the initial visit based on the patient’s clinical history. Patients were then followed up with visits every 2 months, and the occurrence of ear, nose, and throat infection episodes was documented at 6, 12, 18, and 24 months after the start of the study. Results: The results demonstrated a strong potential for preventing ear, nose, and throat infections, with a reduction in the number of episodes by 75.68%, 82.27%, 82.78%, and 89.88% at 6, 12, 18, and 24 months, respectively. No adverse effects related to sublingual bacterial immunotherapy administration were reported. Conclusion: The results suggested that long-term sublingual bacterial immunotherapy is safe and effectively prevents ear, nose, and throat infections, even after treatment ends.
Standardizing Sonography Pre-clinical Instruction Utilizing Peyton’s 4-Step Approach
Authors: Wampler Kathryn , Sundberg Brandy , Ridenour Angela , Michael Kimberly 
Published: January 2025

Objective: The aim of this quality improvement project was to use Peyton’s 4-step approach to standardize sonography pre-clinical lab instruction between diagnostic medical sonography (DMS) educational sites and instructors. Materials and Methods: The participants included DMS students (n = 26) enrolled at a Midwestern university during academic years of 2020–2022. Pre-survey and post-survey were used to collect and analyze data related to sonography lab instruction with Peyton’s 4-step approach. Results: Pre-survey data found no students were familiar with Peyton’s approach. Semester end post-surveys showed students found all steps of Peyton’s approach helpful in learning sonography skills, but results varied by semester. Conclusion: Peyton’s approach with modifications was used to standardized pre-clinical lab instruction in a DMS program across multiple educational sites and all lab sessions. While the approach required more initial planning and preparatory time than a traditional teaching method, the approach provided a structured sequence and order to the learning process, which most students found helpful.
Masquelet’s induced membrane technique in the upper limb: a systematic review of the current outcomes
Authors: Pederiva Davide , De Luca Lapo , Faldini Cesare , Vergano Luigi Branca 
Published: January 2025

Abstract

Background
The Masquelet induced membrane technique is a surgical procedure that allows the reconstruction of segmental bone defects using a relatively simple approach that requires minimal resources from both the healthcare facility and the patient. Historically applied to the lower limb, this technique is gaining increasing attention in the literature for its use in the upper limb.

Methods
A systematic review of the literature was conducted using the PubMed and Google Scholar databases to identify all studies reporting the outcomes of the Masquelet induced membrane technique in the long bones of the upper limb (humerus, radius, and ulna) with a sample size of at least 3 patients. The papers had to include the length of the bone defect, a description of the protocol used for treatment, the complications of each case, and the anatomical location of the defect. The studies that did not meet the above inclusion criteria were excluded.

Results
The search identified 1044 studies, of which 15 met the inclusion criteria. These studies described a total of 156 patients with a mean age of 42 years. The affected bone segments included the humerus in 22 cases and the forearm in 134 cases. In 108 cases, the bone defect was septic. The average defect length was 4.5 cm. PMMA was used as a spacer in all cases, with antibiotics added in 77% of them. The average time interval between the first and second phases of the procedure was 9.5 weeks, and bone union took an average of 5.5 months. The mean follow-up duration was 48 months, and the complication rate was 21%, ranging from 0% to 75%.

Conclusions
The Masquelet induced membrane technique is a viable surgical option for managing segmental bone defects of the upper limb. However, the complication rate remains significant. Further research is needed to identify strategies to improve the outcomes of this technique.

Level of Evidence: Level 2.
Prevalence and dynamics of antimicrobial resistance in pioneer and developing Arctic soils
Authors: Roy Shamik , Dawson Robin A. , Bradley James A. , Hernández Marcela 
Published: January 2025

Abstract
Antimicrobial resistance (AMR) in soil is an ancient phenomenon with widespread spatial presence in terrestrial ecosystems. However, the natural processes shaping the temporal dissemination of AMR in soils are not well understood. We aimed to determine whether, how, and why AMR varies with soil age in recently deglaciated pioneer and developing Arctic soils using a space-for-time approach. Specifically, we assess how the magnitude and spread of AMR changes with soil development stages, including antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and antibiotic-resistant bacteria (ARB). We showed that ARGs, MGEs, and ARB are present, and exhibit a non-uniform distribution in the developing soils. Their abundance generally increases with soil age but at different rates overall and across different glacier forefields. Our analyses suggest a strong positive relationship between soil age and ARGs and ARB, which we attribute to increased competition between microbes in older soils. We also observed a strong negative relationship between soil age and ARG diversity mediated by soil organic matter – suggesting facilitation due to the alleviation of nutrient limitation. These contrasting results suggest that both competition and facilitation can regulate AMR spread through time in the Arctic, but competition might be the stronger determinant of AMR spread.
Rationale and design of the multicenter, national, randomized, open labeled phase III trial: allogeneic stem cell transplantation as a potential curative treatment for patients with relapsed or progressed multiple myeloma (AlloRelapseMM Study)
Authors: Glöckner Annemarie , Schönland Stefan , Einsele Hermann , Kröger Nicolaus 
Published: January 2025

Abstract

Background
Even though major improvements have been made in the treatment of myeloma, the majority of patients eventually relapse or progress. Patients with multiple myeloma who relapse after initial high-dose chemotherapy with autologous stem cells have a median progression free survival up to 2–3 years, depending on risk factors such as previous remission duration. In recent years, growing evidence has suggested that allogeneic stem cell transplantation could be a promising treatment option for patients with relapsed or progressed multiple myeloma. However, prospective randomized trials including allogeneic stem cell transplantation as second-line therapy do not exist to date and therefore urgently needed to demonstrate the value of this therapy in the overall setting of patients with multiple myeloma.

Methods
This clinical trial is a national, multicenter, randomized, open labeled phase III study conducted in 30 hospitals spread all over Germany. After study inclusion, all patients will receive 3 cycles of salvage therapy with one of the currently approved triplet regimens for first relapse. After 3 cycles of salvage therapy, remission status will be assessed. If the patient achieves at least stable disease, partial or complete remission and an HLA compatible stem cell donor could be identified, he/she will be randomized (1:1) to the control or interventional study arm. Approximately 400 patients will be enrolled to enable a randomization of 280 patients. The primary endpoint is overall survival at five years after randomization. The main secondary objectives and endpoints are progression-free survival rate, time-to first occurrence of an infection with CTCAE grade 3–5, non-relapse mortality rate and incidence of acute and chronic graft-versus-host disease after allogeneic stem cell transplantation.

Discussion
The present clinical study is designed to evaluate the superiority of allogeneic stem cell transplantation compared to conventional therapy (triplet chemotherapy) for the difference in overall survival at 5 years, toxicity and quality of life in patients with multiple myeloma who have relapsed or progressed after first-line autologous stem cell therapy.

Trial registration
ClinicalTrials.gov (NCT05675319) registered on January 9, 2023.