bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Photodynamic Therapy Properties of a Water-Soluble Hypocrellin Modified by Cyclodextrin
Authors: Ou Zhi-Ze , Chen Jing-Rong , Wang Xue-Song , Zhang Bao-Wen , Cao Yi 
Published: March 2003

Abstract
For improving water solubility of hypocrellin B (HB), a cyclodextrin modified hypocrellin B (HBCD) was designed and synthesized. Electron spin resonance (ESR) measurement indicated that this HB derivative remained photodynamically active in terms of type I and type II mechanisms. HBCD is water-soluble and possesses stronger photosensitized damage ability to calf thymus DNA than hypocrellin B.
Di- and Trinuclear Nickel(II) Complexes Containing Tripodal Hexadentate Ligands
Authors: Ohta Hiromi , Harada Kenji , Irie Koji , Kashino Setsuo , Kambe Takashi , Sakane Genta , Shibahara Takashi , Takamizawa Satoshi , Mori Wasuke , Nonoyama Matsuo , Hirotsu Masakazu , Kojima Masaaki 
Published: March 2003

Abstract
The reaction of Ni2+ with a tripodal hexadentate ligand (H3L = 1,1,1-tris(N-salicylideneaminomethyl)ethane) afforded the O–H···O bridged dinuclear [Ni2(HL)2] complex. When Ni2+ was allowed to react with H3L in the presence of triethylamine (3 : 2 : 6), the linear trinuclear [Ni3(L)2] complex formed, where the central nickel(II) ion is bridged by six phenolate oxygen atoms to the terminal nickel(II) ions.
EPR Study of Cu(II) in N-Terminal Lobe Fragment of Hen Ovotransferrin
Authors: Kawabata Teruyuki , Fujisawa Masayoshi , Hida Akira I , Okada Shigeru 
Published: March 2003

Abstract
The N-terminal lobe fragment of hen ovotransferrin was prepared by trypsin digestion and the following gel filtration and ion-exchange chromatography. EPR spectra of Cu(II) complex of the N-terminal fragment were recorded independently from the C-terminal lobe and a major spectrum of the copper(II) complex showed g// = 2.300 and g⊥ = 2.061 with ACu// = 14.0 mT, ACu⊥ = 2.20 mT, which had a superhyperfine splitting (AN⊥ = 1.44 mT) of a nitrogen ligand, which may correspond to type A-1 site of copper binding position in the N-terminal lobe of hen ovotransferrin.
A Novel Lanthanide–Transition Metal Complex Constructed by Orotic Acid
Authors: Sun Daofeng , Cao Rong , Liang Yucang , Hong Maochun 
Published: March 2003

Abstract
Hydrothermal reaction of Cu(CH3COO)2·5H2O and NdCl3·6H2O with orotic acid (2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, H3dtpc) in water gave rise to a novel polymeric complex, [Nd2Cu3(Hdtpc)6(H2O)4]n, with two-dimensional layer structure. Nd(III) atom is nine-coordinated by nitrogen and oxygen atoms of Hdtpc ligands and water molecules and Cu(II) atom is four-coordinated by two chelated Hdtpc in a square planar geometry. The hydrogen bond interactions among layers lead to the formation of three-dimensional network structure.
An Efficient and Mild Procedure for the Preparation of Benzoic Acids via Oxidation of Aromatic Carbonyl Compounds by Employing N-Bromoimides and Mercuric Acetate System
Authors: Anjum Amena , Srinivas P 
Published: March 2003

Abstract
Aromatic carbonyl compounds are efficiently converted into the corresponding benzoic acids under mild reaction conditions by employing N-bromoimide and mercuric acetate in good to excellent yields. This procedure works efficiently at room temperature for aromatic aldehydes as well as aromatic ketones to give the corresponding benzoic acids.
Self-Assembly of a Novel Infinite Triple Helices Coordination Polymer {[Co(4,4′-bipyridine)(4,4′-azobispyridine)2(NCS)2]·H2O}n via Hydrogen-Bonding Interaction
Authors: Li Baolong , Liu Huibiao , Xu Yan , Chen Jietong , Xu Zheng 
Published: March 2003

Abstract
The novel complex {[Co(bpy)(azpy)2(NCS)2]·H2O}n (where bpy = 4,4′-bipyridine, azpy = 4,4′-azobispyridine) comprising unprecedented three parallel interpenetrating two-dimensional (4,4) networks and forming novel infinite triple helices via hydrogen-bonding interaction, has been synthesized and characterized.
Highly Stereoselective 7-Membered Ring Synthesis Based upon the Oxidopyrylium–Alkene [5+2]Cycloaddition Reaction
Authors: Ohmori Naoki , Miyazaki Toru , Kojima Satoshi , Ohkata Katsuo 
Published: March 2003

Abstract
The [5+2]cycloaddition reaction of 2-substituted-3-oxidopyrylium betaine with dialkyl fumarates was found to proceed with stereoselectivity up to 15.5 : 1. The stereoselectivity became higher as either the 2-substituent of the 3-oxidopyrylium or the alkoxy group of the fumarate became larger. The stereoselectivity could be rationalized by considering these steric effects.
ZnO Marker for a Radio Frequency ESR Spectrometer
Authors: Ito Tomohiro , Sugawara Michio , Ogata Tateaki 
Published: March 2003

Abstract
The marker for quantitative determination of free radicals by a radio frequency (RF) electron spin resonance (ESR) spectrometer operating at about 700 MHz was found for the first time. It is zinc(II) oxide (ZnO) with the ESR signal due to oxygen vacancy. The g-value was about 1.96 and also the line shape was sharp. When this marker was measured together with TEMPOL aqueous solution by using the RF ESR spectrometer, each signal did not overlap. Furthermore, the signal intensity ratio of TEMPOL to ZnO unchanged even if Q-value of a resonator was decreased.
Crystallization of Calcium Oxalate in Liposome Solutions of Different Carboxylates
Authors: Ouyang Jian-Ming , Duan Li , He Jian-Hua , Tieke Bernd 
Published: March 2003

Abstract
The effects of tri-, di- and monocarboxylate on the growth of nanoparticles of calcium oxalate (CaOxa) were first investigated in liposome system. Sodium acetate (NaAc) only induced calcium oxalate monohydrate (COM), while sodium tartrate (Na2tart) and sodium citrate (Na3cit) could induce calcium oxalate dihydrate (COD) with a preferential growth of (213) crystal face. The promotion effectiveness to COD followed this order: Na3cit &gt; Na2tart &gt; NaAc.
Sequential Carbometalation/Elimination Reaction Takes Place between Gallium Enolate and Chloroethyne
Authors: Amemiya Ryo , Fujii Akiko , Arisawa Mieko , Yamaguchi Masahiko 
Published: March 2003

Abstract
In the presence of GaCl3, silyl enol ethers are sequentially ethynylated at the α-carbon atom with chlorotrimethylsilylethyne giving α-enynylated, α-endiynylated and α-entriynylated ketones.
Temperature Effect on Layer-by-Layer Self-assembly of Linear Polyions and Silica Multilayers
Authors: Shi Jingshi , Hua Feng , Cui Tianhong , Lvov Yuri M 
Published: March 2003

Abstract
Alternate layer-by-layer self-assembly of linear polyions and colloidal silica at elevated temperatures has been investigated by QCM and SEM. A growth step at 90 °C for these multilayers was about 100–200% larger than the one at 20 °C.
7,7-Dicyano-8,8-bis[4-(N,N-dimethylamino)phenyl]-meta-xylylenes: The First Stable Zwitterionic Metaxylylene Derivatives
Authors: Kawase Takeshi , Iwata Tohru , Oda Masaji 
Published: March 2003

Abstract
Treatment of 3-lithiophenyldicyanomethide ions with Michler’s ketone afforded the title compounds as stable crystals upon weak-acidic work-up. The molecular structure and spectroscopic data reveal the zwitterionic nature of the compounds.
An Open-framework Zincophosphate with Intersecting Channels
Authors: Zhao Yongnan , Son Jung-Ho , Kwon Young-Uk 
Published: March 2003

Abstract
An open-framework zincophosphate has been synthesized under hydrothermal conditions; its structure is constructed by PO4, ZnO4 and ZnO6 groups; the linkage of PO4 and ZnO4 give rise to a sheet structure that is pillared by ZnO6 forming a two-dimensional intersecting channel system.
Thin Silica Film with a Network Structure as Prepared by Surface Sol-Gel Transcription on the Poly(styrene-b-4-vinylpyridine) Polymer Film
Authors: Fujita Norifumi , Otsuka Hideyuki , Takahara Atsushi , Shinkai Seiji 
Published: March 2003

Abstract
Sol-gel polycondensation of tetraethyl orthosilicate (TEOS) was carried out on the cast film of poly(styrene-b-4-vinylpyridine) under basic (benzylamine), acidic (AcOH), and neutral (no catalyst) conditions. It was found that only under the acidic and neutral conditions, the phase-separated periodic structure of the copolymer is finely transcribed into the silica. This is a new, convenient method to create the thin, mosaic film from inorganic materials.
Use of 111In–L–LDL radiotracers to detect human pancreatic and mice melanoma tumors
Authors: Urizzi Pascale , Souchard Jean‐Pierre , Ratovo Ginette , Coulais Yvon , Nepveu Françoise , Hollande Etienne 
Published: March 2003

AbstractThe present study was designed to evaluate the potential of labeled low‐density lipoprotein with 111In using a lipid chelating agent (bis(stearylamide) of diethylenetriaminepentaacetic acid: L) to detect pancreatic tumors and melanoma in mice by gamma‐scintigraphy. We compare the biodistribution of radioactivity and scintigraphic images in nude mice heterotransplanted with human cancerous pancreatic duct cells (Capan‐1) and in mice transplanted with murine tumor cells (B16 melanoma). Biodistribution studies showed that radioactivity was twice as high in the Capan‐1 xenograft after injection of the radiolabel than after injection of radiometal alone, and 34‐fold higher in the B16 tumor. On gamma‐scintigraphic imaging, the Capan‐1 tumor was just visible, whereas the B16 melanoma was clearly imaged. The lack of contrast of the Capan‐1 tumor compared with the B16 melanoma could be due to a poor vascularization. Copyright © 2003 John Wiley & Sons, Ltd.
Non‐Metathetic Behavior Patterns of Grubbs' Carbene
Authors: Alcaide Benito , Almendros Pedro 
Published: March 2003

AbstractGrubbs' carbene complex [Cl2(Cy3P)2RuCHPh] and its second‐generation counterpart [Cl2(Im)(Cy3P)RuCHPh] have demonstrated remarkable efficiency metathesizing olefins. Furthermore, a growing number of newly discovered catalytic processes mediated by this complex broaden its synthetic utility beyond olefin metathesis. In addition, the ready availability of these stable ruthenium‐based catalysts coupled with their tolerance toward a wide variety of common functional groups make Grubbs' catalysts very convenient synthetic tools. This paper presents recent advances in the non‐metathetic behavior patterns of Grubbs' carbene.
Total Synthesis of Mannosyl Tryptophan and Its Derivatives
Authors: Manabe Shino , Marui Yoshihiko , Ito Yukishige 
Published: March 2003

AbstractGlycosylation is one of the most important post‐ or co‐translational modifications of proteins, which affects the biological activities of the parent proteins by influencing the higher‐order structure. Recently, a highly novel variant of glycoproteins that incorporate a C‐glycosylated amino acid was identified in various proteins. The total synthesis of one such C‐glycosyl amino acid, namely, C 2‐α‐D‐C‐mannosylpyranosyl‐L‐tryptophan and related peptides were successfully achieved. The mannose and tryptophan moieties were connected via ring opening of benzyl‐protected 1,2‐anhydro‐mannose by a lithiated indole derivative. After the functional group conversion and deprotection steps, the glyco‐amino acid was synthesized in a concise and stereoselective manner, in high overall yields. The stereoisomer, C 2‐α‐D‐C‐glycosylpyranosyl‐L‐tryptophan was synthesized in a similar way. Furthermore, it was revealed that the intermediate azido acid can serve as a useful building block for peptide elongation. A synthetic route for the peptide bond formation of a glycopeptide, without protection of the hydroxyl groups, using the triazine salt derivative as a coupling reagent is also reported.
Synthesis of Perfluoroalkyl‐Substituted Bis(oxazolines) as Ligands for Catalytic Enantioselective Reactions
Authors: Annunziata Rita , Benaglia Maurizio , Cinquini Mauro , Cozzi Franco , Pozzi Gianluca 
Published: March 2003

AbstractTwo chiral perfluoroalkyl‐substituted bis(oxazolines) (F‐box) have been prepared for the first time by a reaction sequence that involved formation of the properly functionalized box followed by introduction of two (ligand 9) or four (ligand 6) n‐C8F17 residues. The fluorine content of these F‐box was 49.2 and 55.5%, respectively. These ligands were employed in the ene reaction between α‐methylstyrene and ethylglyoxalate carried out in the presence of [Cu(OTf)2] (up to 67% ee), and in the cyclopropanation of styrene in combination with CuOTf (up to 78% ee). In both cases the F‐box with the lower fluorine content performed better than the more fluorinated one in terms of chemical yield and enantioselectivity. Ligand 9 was recovered by flash chromatography; ligand 6 by phase separation of the reaction solvents. Comparisons between the use of perfluoroalkyl groups and of soluble and insoluble polymers as solubility devices for the recovery and recycling of the bis(oxazoline) ligand are also reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Cover Picture: Titanium‐Mediated Carboxylation of Alkynes With Carbon Dioxide (Eur. J. Org. Chem. 7/2003)
Authors: Six Yvan 
Published: March 2003

AbstractThe cover picture shows the titanium‐mediated carboxylation of alkynes. A titanacyclopropene intermediate is generated by a ligand exchange reaction. This species reacts with carbon dioxide to give a five‐membered complex, which can be trapped with various electrophiles. Tri‐ or tetra‐substituted vinylcarboxylic acids of well‐defined stereochemistry and butenolides are thus obtained. In the course of this work, a practical procedure was developed for the preparation of (η2‐cyclopentente)diisopropyloxytitanium, which was also shown to react with carbon dioxide. Details are discussed in the article by Y. Six on p. 1157 ff.
First Intramolecular Aglycon Delivery onto a D‐Fucofuranosyl Entity for the Synthesis of α‐D‐Fucofuranose‐Containing Disaccharides
Authors: Gelin Muriel , Ferrières Vincent , Lefeuvre Martine , Plusquellec Daniel 
Published: March 2003

AbstractIntramolecular aglycon delivery was performed for the first time starting from n‐pentenyl glycofuranoside as a donor. p‐Methoxybenzyl‐assisted aglycon transfer required very mild reaction conditions and was promoted by N‐iodosuccinimide without assistance of any Lewis acid catalyst. As a result, rare α‐D‐fucofuranose‐containing disaccharides were obtained. Moreover, structure elucidation led to the conclusion that an N‐succinimidyl residue was still present in the resulting products. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Structurally diagnostic ion–molecule reactions: acylium ions with α‐, β‐ and γ‐hydroxy ketones
Authors: Moraes L. A. B. , Eberlin Marcos N. 
Published: March 2003

AbstractGas‐phase reactions of four acylium ions and a thioacylium ion with three isomeric α‐, β‐ and γ‐hydroxy ketones are performed by pentaquadrupole mass spectrometric experiments. Novel structurally diagnostic reactions are observed, and found to correlate directly with interfunctional group separation. All five ions tested (CH3CO+, CH2CHCO+, PhCO+, (CH3)2NCO+ and (CH3)2NCS+) react with the γ‐hydroxy ketone (5‐hydroxy‐2‐pentanone) to form nearly exclusively a cyclic oxonium ion of m/z 85 that formally arises from hydroxy anion abstraction. With the β‐hydroxy ketone (4‐hydroxy‐2‐pentanone), CH2CHCO+, PhCO+ and (CH3)2NCO+ form adducts that undergo fast cyclization via intramolecular water displacement, yielding resonance‐stabilized cyclic dioxinylium ions. With the α‐hydroxy ketone (3‐hydroxy‐3‐methyl‐2‐butanone), PhCO+, (CH3)2NCO+ and (CH3)2NCS+ form stable adducts. Evidence that these adducts display cyclic structures is provided by the triple‐stage mass spectra of the (CH3)2NCS+ adduct; it dissociates to (CH3)2NCO+ via a characteristic reaction–dissociation pathway that promotes sulfur‐by‐oxygen replacement. If cyclizations are assumed to occur with intramolecular anchimeric assistance, relationships between structure and reactivity are easily recognized. Copyright © 2001 John Wiley & Sons, Ltd.
Automated deconvolution and deisotoping of electrospray mass spectra
Authors: Wehofsky Marco , Hoffmann Ralf 
Published: March 2003

AbstractElectrospray ionization (ESI) of peptides and proteins produces a series of multiply charged ions with a mass/charge (m/z) ratio between 500 and 2000. The resulting mass spectra are crowded by these multiple charge values for each molecular mass and an isotopic cluster for each nominal m/z value. Here, we report a new algorithm simultaneously to deconvolute and deisotope ESI mass spectra from complex peptide samples based on their mass‐dependent isotopic mean pattern. All signals corresponding to one peptide in the sample were reduced to one singly charged monoisotopic peak, thereby significantly reducing the number of signals, increasing the signal intensity and improving the signal‐to‐noise ratio. The mass list produced could be used directly for database searching. The developed algorithm also simplified interpretation of fragment ion spectra of multiply charged parent ions. Copyright © 2002 John Wiley & Sons, Ltd.
Characterization of geometrid sex pheromones by electrospray ionization time‐of‐flight mass spectrometry
Authors: Yamazawa Hiroyuki , Yamamoto Masanobu , Karasawa Kaoru Iida , Pu Guan‐Qin , Ando Tetsu 
Published: March 2003

AbstractThe utility of liquid chromatography combined with time‐of‐flight mass spectrometry (LC/TOFMS) was demonstrated for studies on chiral unsaturated epoxy compounds, sex pheromones produced mainly by female moths in the family Geometridae. By electrospray ionization (ESI), each synthetic epoxyalkadiene derived from (Z,Z,Z)‐3,6,9‐triene with a C18–C23 straight chain showed three ion series, [M + NH4]+, [M + H]+ and [M − OH]+, with high resolution and good sensitivity, indicating its molecular formula. In addition to these, characteristic fragment ions at m/z M − 57 and M − 71 for the 3,4‐epoxides and at m/z M − 123 and 123 for the 9,10‐epoxides were detected, whereas the 6,7‐epoxides did not produce fragment ions that reflected their structures. Monitoring these diagnostic ions during the LC/MS analysis of a gland extract, the natural sex pheromone of the mulberry looper was confirmed to be (Z,Z)‐cis‐9,10‐epoxy‐3,6‐octadecadiene, which was separable from the other positional isomers on an ODS column. Furthermore, (Z,Z)‐cis‐3,4‐epoxy‐6,9‐nonadecadiene secreted by the Japanese giant looper was analyzed with a chiral column, and the stereochemistry was determined directly. Copyright © 2003 John Wiley & Sons, Ltd.
Interactions among nitric oxide and Bcl‐family proteins after MPP+ exposure of SH‐SY5Y neural cells II: Exogenous NO replicates MPP+ actions
Authors: Dennis Jameel , Bennett James P. 
Published: March 2003

AbstractIn the preceding companion article, we showed that the neurotoxin methylpyridinium (MPP+) increases mitochondrial nitric oxide (NO), causes a post‐transcriptional, NO‐dependent increase in Bax protein and produces caspase‐dependent apoptosis and caspase‐independent cell death. In the present study, we show that exogenous NO replicates these findings. The long‐term NO generator diethylenetriamine‐NO (DETA‐NO) reproduced the post‐transcriptional Bax protein increase, but did not increase Bcl‐2 or Bcl‐XL proteins. Like MPP+, DETA‐NO caused an early decrease in Bcl‐2 mRNA, did not increase Bax protein in ρ0 cells and caused caspase‐ and cycloheximide‐dependent apoptosis and caspase‐independent cell death. We developed cell lines with inducible overexpression of Bcl proteins, at levels relevant to those we found in cells exposed to MPP+ or DETA‐NO. Inducible overexpression (∼2‐fold) of Bcl‐2 or Bcl‐XL proteins reduced MPP+ or NO‐induced apoptosis but did not affect cell death. Inducible Bax overexpression (∼5‐fold) slightly increased cell death. Our results show that exogenous NO mimics actions of MPP+ on SH‐SY5Y neuroblastoma cells and supports the mediation of MPP+ neurotoxicity by NO generated intracellularly in mitochondria. © 2003 Wiley‐Liss, Inc.
Involvement of the α7 subunit of the nicotinic receptor in morphogenic and trophic effects of acetylcholine on embryonic rat spinal motoneurons in culture
Authors: Catone Christelle , Ternaux Jean‐Pierre 
Published: March 2003

AbstractThe morphogenic and trophic effects of acetylcholine (ACh) on embryonic cultured rat spinal cord motoneurons (MNs) through nicotinic α7 autoreceptors were assessed. α7 Subunits of the nicotinic cholinergic receptor were detected in cultures of purified rat spinal embryonic MNs sampled at E15, by both immunocytochemistry and α‐bungarotoxin binding. According to these two methods, α7 subunits are located mainly at somatic and axonal membrane. Functional involvement of the α7 subunit in survival and development of morphological properties of growing cultured MNs was tested using an antisense strategy. The antisense oligonucleotide significantly decreases the expression of the α7 protein compared with control and mismatch oligonucleotide‐treated cultures. This decrease in the expression of the α7 protein leads to a significant increase in the number of axonal branches and in the length of the axon. The antisense treatment also induces, as early as the first day in culture, a decrease of MN survival, leading to total cell death at day 5. TUNEL staining revealed that the MNs are dying through apoptotic processes. Thus, our study shows that ACh is a morphogenic and trophic factor. These effects are directly linked to the membrane expression level of α7 protein. Indeed, the lower the α7 expression, the lower the inhibition of axonal growth (i.e., axonal elongation) and the lower the MN survival. © 2003 Wiley‐Liss, Inc.
Isolation and Molecular Structure of 1,1,2,4,5,5-Hexacyano-1,4-pentadienyl Anion. An Unusual Reaction of Tetracyanoethylene with p-Xylene Mediated by a Porphyrinatomanganese(II)
Authors: Sugiura Ken-ichi , Mikami Shinji , Tanaka Takanori , Sawada Masami , Sakata Yoshiteru 
Published: March 2003

Abstract
The reaction of TCNE and meso-tetrakis(4-biphenylyl)porphyrinatomanganese(II) in p-xylene leads to the formation of the 1,1,2,4,5,5-hexacyano-3-(4′-methyphenyl)-1,4-pentadienyl anion, which was characterized by single crystal X-ray diffraction.
Highly Planar Silane [(i-Pr)3Si]3SiH and Silyl Radical [(i-Pr)3Si]3Si·
Authors: Kyushin Soichiro , Sakurai Haruaki , Matsumoto Hideyuki 
Published: March 2003

Abstract
Tris(trialkylsilyl)silane [(i-Pr)3Si]3SiH (1) was synthesized, and the molecule was found to have a nearly planar structure of the polysilane skeleton by X-ray crystallography. Hydrogen abstraction from 1 by tert-butoxyl radical gave the highly stable silyl radical [(i-Pr)3Si]3Si· (2), which also has a planar structure.
Synergistic Effect of PEG-20M and Heptakis(2,3,6-tri-o-pentyl)-β-cyclodextrin Mixed Stationary Phase in Gas Chromatography
Authors: Yuan L M , Fu R N , Chen X X , Gui S H , Dai R J 
Published: March 2003

Abstract
In open tubular column gas chromatography, by investigating the chromatographic properties of the mixed stationary phase containing heptakis(2,3,6-tri-o-pentyl)-β-cyclodextrin and PEG-20M, as well as comparing with the heptakis(2,3,6-tri-o-pentyl)-β-cyclodextrin and the PEG-20M used as individual stationary phase, the synergistic effect was observed on this mixed stationary phase. This separation effects depend on temperature and mixing ratio.
Novel Perfluorocyclohexylation with Bis(perfluorocyclohexane carbonyl) Peroxide
Authors: Sawada Hideo , Kurachi Minaka , Kawase Tokuzo , Takishita Katsuhisa , Tanedani Toshiyuki , Aoshima Kazuyoshi 
Published: March 2003

Abstract
A new bis(perfluorocyclohexane carbonyl) peroxide was prepared by the reaction of the corresponding acyl fluoride and hydrogen peroxide. This peroxide was applicable for the direct introduction of perfluorocyclohexyl group into various organic molecules such as acrylic acid oligomer, benzene and polystyrene; in particular interest, not only equatorial but also axial conformational isomers were isolated in phenylperfluorocyclohexane thus obtained.
A New Approach to Pyrrolophenanthridone Alkaloids via Intramolecular Radical Cyclization
Authors: Tsuge Otohiko , Hatta Taizo , Tsuchiyama Hiroshi 
Published: March 2003

Abstract
A new approach to the synthesis of pyrrolophenanthridone class of alkaloids is described. The method is based on intramolecular radical cyclization of easily accessible 1-aroyl-7-bromoindoles with Bu3SnH and AIBN.