bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the status of tertiary lymphoid structures in invasive pulmonary adenocarcinoma based on chest CT radiomic features
Authors: Yu Ye , Yang Tianshu , Ma Pengfei , Zeng Yan , Dai Yongming , Fu Yicheng , Liu Aie , Zhang Ying , Zhuang Guanglei , Zhou Yan , Wu Huawei 
Published: January 2025

Abstract

Objectives
The aim of this study was to determine the status of tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA).

Methods
In this retrospective study, patients with IA from November 2015 to March 2024 were recruited from two independent centers (center 1, training and internal test data set; center 2, external test data set). TLS was divided into two groups according to hematoxylin-eosin staining. Radiomic features were extracted, and support vector machine (SVM) were implemented to predict the status of TLSs. Receiver operating characteristic (ROC) curves were used to analyze diagnostic performance. Furthermore, visual assessments of the test set were also conducted by two thoracic radiologists and compared with the radiomics results.

Results
A total of 456 patients were included (training data set, n = 278; internal test data set, n = 115; external test data set, n = 63). The area under the curve (AUC) of the radiomics model on the validation set, the internal test set, and the external test set were 0.781 (95% confidence interval (CI): 0.659–0.905;), 0.804 (95% CI: 0.723–0.884;) and 0.747 (95% CI: 0.621–0.874;), respectively. In the visual assessments, the mean CT value and air bronchogram were important indicators of TLS, the AUC was 0.683. In the external test set, the AUC of the clinical model was 0.632.

Conclusions
The radiomics model has a higher AUC than the clinical model and effectively discriminates TLSs in patients with IA.

Critical relevance statement
This study demonstrates that the radiomics-based model can differentiate TLSs in patients with IA. As a non-invasive biomarker, it enhances our understanding of tumor prognosis and management.

Key Points

TLSs are closely related to favorable clinical outcomes in non-small cell lung cancer.

Radiomics from Chest CT predicted TLSs in patients with IA.

This study supports individualized clinical decision-making for patients with IA.

Graphical Abstract
Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males
Authors: Liu Rachel , Galiwango R. M. , Park Daniel , Huibner Sanja , Aziz Maliha , Anok Aggrey , Nnamutete James , Isbirye Yahaya , Wasswa John Bosco , Male Deo , Kigozi Godfrey , Tobian Aaron A. R. , Prodger Jessica L. , Liu Cindy , Coburn Bryan , Kaul Rupert 
Published: January 2025

Abstract

Background

Genital inflammation increases HIV susceptibility and is associated with the density of pro-inflammatory anaerobes in the vagina and coronal sulcus. The penile urethra is a critical site of HIV acquisition, although correlates of urethral HIV acquisition are largely unknown. While Streptococcus mitis is a consistent component of the urethral flora, the presence of Gardnerella vaginalis has been linked with prior penile-vaginal sex and urethral inflammation. Here, we use a flow cytometry-based bacterial assay to quantify urethral IgA and IgG that bind G. vaginalis and S. mitis in a cross-sectional cohort of 45 uncircumcised Ugandan men and to evaluate their association with the urethral microbiome and local soluble immune factors.

Results
Urethral antibodies binding both bacterial species were readily detectable, with G. vaginalis predominantly bound by IgA, and S. mitis equivalently by IgA and IgG. Gardnerella vaginalis-binding IgA was elevated in participants with detectable urethral Gardnerella, with the latter only present in participants who reported prior penile-vaginal sex. In contrast, detectable urethral S. mitis was not associated with sexual history or levels of S. mitis-binding IgA/IgG. The time from the last penile-vaginal sex was inversely correlated with the urethral concentrations of total IgA, G. vaginalis-binding IgA, and chemokines IL-8 and MIP-1β; these inflammatory chemokines were independently associated with higher total IgA concentration, but not with G. vaginalis-binding IgA.

Conclusions
This first description of microbe-binding antibodies in the penile urethra suggests that urethral colonization by Gardnerella after penile-vaginal sex specifically induces a G. vaginalis-binding IgA response. Prospective studies of the host-microbe relationship in the urethra may have implications for the development of vaccines against sexually-transmitted bacteria.
A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome
Authors: Xiong Sujie , Hu Guangyao , Zhou Yao , Sun Fei , Ma Yanlin 
Published: January 2025

Abstract

Background
The dynein cytoplasmic two heavy chain 1 (DYNC2H1) gene encodes a cytoplasmic dynein subunit. Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the “retrograde” cellular motor. Mutations in DYNC2H1 are the main causative mutations of short rib-thoracic dysplasia syndrome type III with or without polydactyly (SRTD3). Early diagnosis of SRTD3 prenatally by ultrasound alone is difficult. In this case, a couple who gave birth to three consecutive babies with SRTD3 requested fertility guidance to avoid having another baby with SRTD3.

Methods
Cytogenetic and molecular genetic analyses of amniotic fluid via whole-genome sequencing (WGS), routine G-banded karyotype analysis, fluorescent quantitative polymerase chain reaction, and whole-exome sequencing (WES) were performed at 19 weeks. Peripheral blood samples from the parents were also screened by Sanger sequencing for SRTD3-related mutations.

Results
Two compound heterozygous mutations, c.10,594 C > T and c.7720G > A, in the DYNC2H1 gene were identified, which were inherited from the mother and father, respectively. The foetus’s mother is heterozygous for the c.10,594 C > T variant, and the foetus’s father is heterozygous for the c.7720G > A variant. The mutation c.10,594 C > T, which is a nonsense mutation believed to be pathogenic, has been previously reported. The mutation c.7720G > A, which is a missense mutation, has yet to be reported. Moreover, no chromosomal abnormalities or pathogenic copy number variations (CNVs) were detected in the foetus. The patient did not become pregnant after PGT-M and IVF-ET. This family subsequently accepted donated eggs; a successful pregnancy occurred, and a healthy girl was born.

Conclusion
The compound heterogeneous mutations in DYNC2H1 ultimately accounts for the diversity of disease phenotypes reported in this study and can be used to guide future pregnancies. Our findings expand the mutation spectrum of DYNC2H1 in this rare disease and highlight the value of WES in the diagnosis of skeletal dysplasia with unclear prenatal indications.
CompositIA: an open-source automated quantification tool for body composition scores from thoraco-abdominal CT scans
Authors: Cabini Raffaella Fiamma , Cozzi Andrea , Leu Svenja , Thelen Benedikt , Krause Rolf , Del Grande Filippo , Pizzagalli Diego Ulisse , Rizzo Stefania Maria Rita 
Published: January 2025

Abstract

Background
Body composition scores allow for quantifying the volume and physical properties of specific tissues. However, their manual calculation is time-consuming and prone to human error. This study aims to develop and validate CompositIA, an automated, open-source pipeline for quantifying body composition scores from thoraco-abdominal computed tomography (CT) scans.

Methods
A retrospective dataset of 205 contrast-enhanced thoraco-abdominal CT examinations was used for training, while 54 scans from a publicly available dataset were used for independent testing. Two radiology residents performed manual segmentation, identifying the centers of the L1 and L3 vertebrae and segmenting the corresponding axial slices. MultiResUNet was used to identify CT slices intersecting the L1 and L3 vertebrae, and its performance was evaluated using the mean absolute error (MAE). Two U-nets were used to segment the axial slices, with performance evaluated through the volumetric Dice similarity coefficient (vDSC). CompositIA’s performance in quantifying body composition indices was assessed using mean percentage relative error (PRE), regression, and Bland–Altman analyses.

Results
On the independent dataset, CompositIA achieved a MAE of about 5 mm in detecting slices intersecting the L1 and L3 vertebrae, with a MAE < 10 mm in at least 85% of cases and a vDSC greater than 0.85 in segmenting axial slices. Regression and Bland–Altman analyses demonstrated a strong linear relationship and good agreement between automated and manual scores (p values < 0.001 for all indices), with mean PREs ranging from 5.13% to 15.18%.

Conclusion

CompositIA facilitated the automated quantification of body composition scores, achieving high precision in independent testing.

Relevance statement

CompositIA is an automated, open-source pipeline for quantifying body composition indices from CT scans, simplifying clinical assessments, and expanding their applicability.

Key Points

Manual body composition assessment from CTs is time-consuming and prone to errors.

CompositIA was trained on 205 CT scans and tested on 54 scans.

CompositIA demonstrated mean percentage relative errors under 15% compared to manual indices.

CompositIA simplifies body composition assessment through an artificial intelligence-driven and open-source pipeline.

Graphical Abstract
Concomitant Exacerbation of Graves Orbitopathy and Double-Seronegative Myasthenia Gravis after SARS-CoV-2 Infection
Authors: Nakano Yuto , Takeshima Ken , Furukawa Yasushi , Morita Shuhei , Sakata Mayumi , Matsuoka Taka-Aki 
Published: January 2025

Abstract
SARS-CoV-2 infection could trigger autoimmune disease. We report a case of concomitant exacerbation of Graves orbitopathy (GO) and myasthenia gravis (MG) after SARS-CoV-2 infection. A 43-year-old woman had diplopia, proptosis, and swollen eyelids. Blood tests showed thyrotoxicosis and positive thyroid-stimulating hormone receptor antibodies, and orbital magnetic resonance imaging (MRI) showed enlarged extraocular muscles. She was therefore referred to our hospital with diagnosis of GO. Methylprednisolone pulse therapy (MPT) in combination with orbital radiotherapy were performed for 3 weeks, and ocular symptoms improved. At 41 weeks, the patient was infected with SARS-CoV-2 and felt sudden worsening of diplopia and ptosis. MRI showed an enlarged right inferior rectus muscle. MPT and orbital radiotherapy were performed again for 3 weeks for the suspected GO, but there was insufficient improvement of the ptosis. Serum antiacetylcholine receptor and anti–muscle-specific tyrosine kinase antibodies were negative, but the patient was further evaluated with repetitive nerve stimulation test and ice pack test, and diagnosis was double-seronegative MG. Pyridostigmine treatment led to dramatic improvement of the ptosis. SARS-CoV-2 infection could exacerbate MG as well as GO. Careful diagnosis is required for ocular symptoms after SARS-CoV-2 infection, especially when there is double-seronegative MG.
Mapping a South Asian Sacred Journey
Authors: Poddar Neeraja 
Published: January 2025

Abstract
From at least the sixteenth century, bilampau—horizontal, scroll-like paintings recounting mythological tales—were produced in Nepal. They typically comprise two or three registers where the narrative unfolds sequentially from left to right, top to bottom. A bilampau from circa 1800 is distinctive in that it portrays the pilgrimage—undertaken to this day—to the holy lake of Gosainkund. My article analyzes this singular work of art and imagines how viewers might have engaged with it. It probes how the format of this painting lends itself to the creation of a sacred map, with towns, rivers, and monuments plotted in relation to each other as they might be encountered on a journey. Like the pilgrims in the painting who make their way north through the Kathmandu Valley, the bilampau invites viewers to walk along its length in the direction of Gosainkund; they may choose to stop at any of the numerous sacred spots scattered throughout the landscape. The remnants of ritual substances smeared and sprinkled on the deity represented within the holy lake are still visible, suggesting the painting was once an icon and that worshipping it was perhaps a potent stand-in for a physical pilgrimage.
Cognitive Benefits of Open-Skill Sports in Childhood: Evidence from the ABCD Study
Authors: Shih Chia-Hao , Broadnax Michaela , Eckner James , Veliz Philip , Varangis Eleanna 
Published: January 2025

ABSTRACT

Background
Sports participation in childhood is known to benefit physical health, but its impact on cognitive development, particularly comparing open-skill and closed-skill sports, is less understood.

Methods
This study analyzed baseline data from the Adolescent Brain Cognitive Development (ABCD) study, comprising 11,869 children aged 9-10 years. Participants were categorized into open-skill sports group (OSG), closed-skill sports group (CSG), and non-sport group (NSG). Cognitive performance was assessed using seven tasks from the NIH Toolbox, covering executive function, processing speed, and language domains. Group differences were examined using ANCOVA, controlling for sex, race, parental education, income, Area Deprivation Index (ADI), body mass index (BMI), and total time spent in activities.

Results
In the final analytical sample of 9,898 ABCD participants, the OSG outperformed both the CSG and NSG on executive function tasks, including the Flanker task (p < .01) and List Sorting Working Memory task (p < .01). No significant group differences were found on tasks assessing processing speed, or language domains.

Conclusions
Our findings suggest that participation in open-skill sports may be associated with enhanced cognitive performance in childhood, particularly in executive function and working memory. These results support the idea that dynamic and cognitively demanding activities could play a role in cognitive development during key developmental periods
Alteration in central vascular and cognitive functions during simulated work conditions in males – a secondary analysis from a randomised controlled trial
Authors: Shruthi P Poovitha , Chandran M Obhuli , Chandrasekaran Baskaran , K. Vaishali , Sugumar Suresh , Kadavigere Rajagopal 
Published: January 2025

Background Alteration in the central vascular hemodynamics is speculated to influence cognitive functions, including executive functions in young adults. Prolonged sitting is associated with compromised central vascular functions, which activity micro-breaks could mitigate. However, the association between the carotid vascular hemodynamic alteration and the executive functions is yet to be explored. Methods We administered a randomised controlled trial investigating the effects of various intensities' micro-breaks on central vascular and cognitive functions during simulated work conditions for four hours. The carotid artery hemodynamics and cognitive functions were measured by Duplex ultrasound at 0th, 2nd and 4th hour and computer-based Flanker tests at 0th, 1st, 2nd, 3rd and 4th hour of visit days, respectively. From the randomised controlled trial, we extracted the secondary data of carotid artery hemodynamics and cognitive functions change at the 4th hour from the baseline and analysed for any relation. Results Though we observed linear relation between the carotid artery hemodynamics and the executive functions, the relation was not statistically significant. we found a significant reduction in carotid artery diameter during prolonged sitting (0.03 cm [95%CI 0.01, 0.05]), velocity (10.35 cm/s [95%CI -2.85, 17.86]) and shear rate during interrupted sitting (174.39 [95%CI 65.67, 283.11]) We found increased accuracy during prolonged sitting (12.7% [95%CI 0.66, 24.81]) and sitting with light-intensity activity breaks (6.92% [95%CI 1.39, 12.44]). We did not find any significant relation between the change in central vascular functions (carotid artery diameter, velocity, shear rate and blood flow) and the cognitive functions during three different work conditions. Conclusion Though a significant relation between carotid artery function and cognitive function could not be established, microbreaks can mitigate the vascular and cognitive risks associated with prolonged sitting.
Work Participation of Autistic Adolescents
Authors: Menezes Michelle , Pappagianopoulos Jessica , Mazurek Micah O. 
Published: January 2025

Abstract
This study sought to compare frequency of paid work by autistic adolescents to paid work by adolescents with other neurodevelopmental disorders and typically developing adolescents, and to examine whether demographic and clinical characteristics were associated with autistic adolescent employment with data from 2016–2019 National Survey of Children’s Health. Rate of paid work was significantly lower in the autistic group (22.01%) than typically developing (49.38%) and other neurodevelopmental disorders (44.27%) groups. Younger age, lower household income, co-occurring intellectual disability, and more severe autism were associated with lower odds of an autistic adolescent having worked. This study indicates that work disparities impacting autistic individuals begin in youth and highlights the need for improved vocational support to address employment barriers for autistic youth.
Combined Anterograde and Retrograde Endoscopic Management of Complete Esophageal Obstruction in Absence of Fluoroscopic Guidance
Authors: Maan Muhammad Hassaan Arif , Medina Morales John Esli , Choi Catherine , Ahmad Muhammad Mursaleen , Hajifathalian Kaveh , Wang Weizheng William 
Published: January 2025

ABSTRACT
Complete esophageal obstruction is a major side effect of radiotherapy for head and neck cancers. We present a 65-year-old man with complete esophageal obstruction due to chemoradiotherapy and 7 years of gastric tube dependence. A combined anterograde and retrograde endoscopic procedure was successfully performed using direct transillumination from the anterograde scope to visualize and excise the obstructing mucosa, without fluoroscopic guidance. The patient tolerated the procedure well, with no major complications on follow-up. This fluoroscopy-free rendezvous approach is a safe, effective option with practical applications, particularly in resource-limited settings.
HUBUNGAN STRATEGI MANAJEMEN SUMBER DAYA MANUSIA DAN KINERJA ORGANISASI: STRATEGI ORGANISASI SEBAGAI VARIABEL MODERATING
Authors: Suharnomo Suharnomo , Mas'ud Fuad 
Published: January 2025

The research of Delery and Dotty (1996) concluded that the relationship between HRM strategy and organizational performance were not simple but complicated. The purpose of this research is to reexamine the relationship between HRM strategy and organizational performance by using organizational strategy as a contingent factor in that relationship. Respondents of the research were HRM managers of 81 companies which part of the Top Companies and Big Group in Indonesia, 71h Edition published by Compassindo. The big companies were considered to perform their HRM as a strategic partner (Nurhayati, 2001). The concepts of HRM strategy used in this research based on Bae and Lawler formulation (2000) and the organizational strategy based on Porter (1980). The result of this research shows, there is only one hypothesis supported (H1) of five dimensions of HRM strategy, namely fit between extensive training and differentiation strategy is highly correlated to its organizational performance (r = - 0.401, significant of p = 0.01). On the other hand, hypothesis H2, H3, H4, and HS are not supported. It means that differentiation strategy do not moderrate the relationship between empowering, staffing, performance based pay, broad design and organizational performance. There Is only one of five HRM strategy dimensions which is supporting contingency theory in HRM strategic literature, states that the relationship between HRM strategy and organizational performance is depend on the contextual factor, namely organizational strategy. The concept of fit between HRM strategy and organizational strategy will have a superior performance (Jackson & Sculer, 1995) needs to be explored in the future.
FAKTOR - FAKTOR YANG MEMPENGARUHI KEPUASAN DAN KESETIAAN WISATAWAN
Authors: Raharso Sri 
Published: January 2025

The conceptual framework is proposed that investigates the effects of service quality, image, and price on perceptions of customer satisfaction and loyalty. To test the framework, validity and of reliability analysis, factor analysis, and multiple regresion are applied to data collected from 203 tourist in Bogar Botanical Garden. The result of the study indicate that service quality positively related to satisfaction and loyalty variables. While price and organizational image variables in the reality not have significant influence to satisfaction variable. Price variable only owning influence directly to loyalty. Besides, image variable in the reality nor have significant influence to loyalty. While satisfaction variable alone, owning weak influence to loyalty. Thereby, variable of service quality represent very dominant variable in influencing customer satisfaction and loyalty.
Synthesis and Optimization of Snake Fruit Peel Ash-Derived Silica for Iron (Fe) Removal from Batik Wastewater
Authors: Salamah Siti , Mufandi Ilham , Jumari Jumari , Fadhilah Ainun 
Published: January 2025

The byproduct of the batik industry is a liquid waste containing heavy metals like iron (Fe) which can be harmful to the environment and aquatic ecosystems. The aim of this study is to synthesize and optimize silica derived from snake fruit peel ash as an adsorbent for iron (Fe) in the liquid waste of the batik industry. Snake fruit peel is often overlooked as waste and is identified to have a high silica content. The research method was carried out in the calcination process at a temperature of 650°C for 1 hour to convert and change the snake fruit peel powder into ash, then extracted using a 2M HCl solution. The final stage of silica synthesis is drying and grinding. The Silica characterization was analyzed using the FTIR (Fourier Transform Infrared Spectroscopy) and Surface Area Analyzer (SAA) tests. The metal content in the waste was analyzed with AAS (Atomic Absorption Spectrometer). The results showed that the silica from snake fruit peel ash contains silica constituent groups, namely silanol (Si-OH), as an active site for the adsorption process. The surface area of the silica is around 56.347 m2/g, the total pore volume is about 0.0193 cc/g, and the average pore diameter is approximately 26.6745 mm. The application test on batik liquid waste showed a decrease in Fe concentration from 0.487 mg/L to 0.343 mg/L at contact time of 60 minutes. This research proves that silica from snake fruit peel ash offers an innovative and sustainable solution for the treatment of batik industry liquid waste and in other liquid waste processing.
20 Jahre Erhalt des Instituts für Bibliothekswissenschaft in Deutschland
Authors: Greifeneder Elke 
Published: January 2025

Zusammenfassung
Vor 20 Jahren beschloss das Präsidium der Humboldt-Universität zu Berlin, das Institut für Bibliothekswissenschaft zu schließen. Dieser Artikel beschreibt, was nach diesem Beschluss geschah, warum das Institut heute noch besteht, welche Wirkung Unterstützungsbriefe und Strategiepapiere haben und welche Lehren wir für universitäre Institute, aber auch für Bibliotheken aus 20 Jahre Erhalt des Instituts für Bibliothekswissenschaft ziehen können.