bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Performance of Manufacturing Companies in Indonesia is Reviewed From The Characteristics of The Board of Directors, Audit Committee and Ownership
Authors: Yanto Wedi , Juliani Meily , Candra Rudi 
Published: January 2024

Purpose - This research aims to prove the influence of the characteristics of the board of directors, audit committee, and ownership on the performance of manufacturing companies in Indonesia.
Research Method - Manufacturing companies that are registered on the IDX are used as objects in this research using a purposive sampling method and were obtained from 124 manufacturing companies in 2018-2022. Testing and analysis used Eviews 12 and IBM SPSS Statistics 25 software.
Findings - The results of this study are ownership concentration which has a significant positive effect and independent audit committee, independent board of directors have a significant negative effect on company performance. The results of this research are that ownership concentration has a significant positive effect on company performance. Independent audit committees and independent boards of directors have a significant negative effect on company performance. Meanwhile, other variables do not have a significant effect on company performance.
Implication - GCG can help companies create effective policies. It also can help companies build the trust of stakeholders and shareholders.
Comparative Analysis Of Financial Performance Of Bank Bpd Diy And Bank Jateng For The 2019-2022 Period
Authors: Wende Maria Emerlinda , Paramitalaksmi Ratri 
Published: January 2024

This research aims to determine the comparison of financial performance between BPD DIY and Bank Jateng (formerly: BPD Jateng) in the 2019-2022 period. Research Method – This study uses descriptive analysis, this study uses financial ratio analysis tools, normality test, independent Sample T-test if the data is normally distributed, and Mann Whitney test if the data is not normally distributed. Findings - The conclusion of the research and discussion above, it can be said that Bank BPD DIY and Bank Jateng show significantly different financial performance as shown by the CAR ratio, while the ratio of NIM, ROA, NPL, and BOPO has no significant difference in financial performance. Implication – This research is expected to be a reference for consideration to analyze the comparison of BPD DIY and Bank Jateng and other banks in the future.
التعليم البيزنطي من القرن الخامس حتى العاشر الميلادي
Authors: الطيب أ.فتحية ميمون 
Published: January 2024

كان التعليم أحد الجوانب الحضارية للإمب ا رطورية البيزنطية، وقد عُرف المجتمع البيزنطي بأنَ أغلبهكان مجتمعاً مثقف اً، وظهر فيه الكثير من المهتمين بالعلم والمعرفة، كما وضح دور كثير من الأباطرة في دعمهذا المجال. وجاءت أهمية الموضوع في أن الجوانب الحضارية البيزنطية لم تُدْرس بشكل مفصل، ومن هنا تمتسليط الضوء على التعليم وجوانبه المتعددة سواء الأساتذة أو الطلاب أو العلوم التي دُرست، وقد ا عتمدتُالد ا رسة المنهج السردي التحليلي، وواجهتها صعوبات تمثلت في قلة المصادر البيزنطية والم ا رجع التي تطرقتللجوانب الحضارية، إذ إن أغلب ما وُجد من كتب كان يهتم بالجانب السياسي والعسكري للإمب ا رطورية البيزنطية.توصلت الد ا رسة لعدة نتائج أهمها:
1. إن التعليم البيزنطي كان ساميا في كثير من جوانبه، حيث إنه جسدالواقع الذي عاشته البلاد في تلك الفت ا رت، ولكن من ناحية أخرى نجده في كثير من الأحيان مكملا لنهج منسبقوه من الإغريق والرومان.
2. كان التعليم في بدايته يعتمد بشكل أساسي على الدين، وذلك لقوة العاملالديني في العصور الوسطي، ولكن سيطرة الكنيسة وقوتها بدأت تتلاشي في أواخر العصر البيزنطي.
3. اهتم كثير من الأباطرة بالتشجيع على التعليم والمعرفة، وكان لهم دور كبير في بناء الم ا ركز التعليمية، وإيجادالمعلمين الماهرين للتدريس فيها.
4. ظهر لدى البيزنطيين العديد من العلماء والشخصيات البارزة، التي كانلها بصمتها في كثير من المجالات
انتشار الطاعون في أوروبا في العصر الوسيط
Authors: الطيب د.فتحية ميمون , الدرسي د.عزالدين 
Published: January 2024

تتناول الدراسة بالبحث موضوع انتشار الطاعون في أوربا في العصر الوسيط، قد تم تسجيل ثلاثة أوبئة عالمية كبيرة من الطاعون في العالم تمثلت في الأعوام 541م - 1347 م -1894 م وتسبب كل منها في وفيات مدمرة للناس والحيوانات, وفي كل منها كان الكُتاب والمؤرخين يُسهب في وصف أعراض المرض ونسبة الضحايا وأعمال وتدابير الحكومات إزاءه.
توصلت هذه الدراسة لعدة نتائج من أهمها: (1) إن الطاعون مرض معد وكان أخطرها هو الطاعون الرئوي والذي ينتقل بسرعة عبر الهواء والتنفس. (2) كان سبب انتشار الوباء في أوروبا كان في أغلبها عن طريق التجارة والتجار الذين يأتون من المناطق المصابة بالطاعون بسفنهم وبوخراهم ويستقروا في بعض الموانئ الأوروبية ويكونوا بذلك بؤر وبائية في هذه المناطق. (3) اجتاح الطاعون اوروبا كالنار في الهشيم وأصبح يتنقل بين مدنها وخسر الاوربين الملايين من الناس نتيجة هذا الوباء. (4) أثر الطاعون على الحياة الاوربية وأثر على الاقتصاد والزراعة والصناعة وكان له نتائجه الاجتماعية والنفسية على الناس.
أثر حفظ القران الكريم في التحصيل الدراسي لدى طلبة المرحلة الابتدائية (دراسة حالة لمراكز تحفيظ القران بمنطقة الجبل الاخضر)
Authors: عبدالله العوامي أ.علاء بشير 
Published: January 2024

تهدف الدراسة الى التعرف على أثر حفظ القران الكريم في التحصيل الدراسي لدى طلبة المرحلة الابتدائية بمنطقة الجبل الاخضر وذلك من خلال معدلاتهم الدراسية التي تحصلوا عليها خلال العام الدراسي (2019-2020).
استخدم الباحث المنهج الوصفي المقارن لوصف الوضع الحالي وتفسيره، وابتدأ بذكر مقدمة في فضل القران وحفظه مدعمة بالآيات والأحاديث واقوال العلماء ثم ذكر نبذة تاريخية عن تعليم القران في اقليم برقة من حيث نشأة الكتاتيب في البادية والحضر، مع ذكر بعض الدراسات السابقة التي تناولت موضوع الدراسة، كما قام الباحث باستخدام الأساليب الإحصائية لمقارنة بيانات الطلبة المتمثلة في نتائج المواد الدراسية (الحساب واللغة العربية والتربية الإسلامية) وذلك باستخراج التكرارات والنسب والمتوسط الحسابي والانحراف المعياري.
وقد تكونت عينة الدراسة من 100 طالب وذلك بالرجوع الى سجلاتهم الدراسية بالمدارس الحكومية والخاصة الملتحقين بها، 50 منهم تم اختيارهم بطريقة قصدية كونهم ملتحقين بمراكز التحفيظ بمنطقة الجبل الأخضر بمدينتي البيضاء وشحات بالتحديد، و50 تم اختيارهم بطريقة عشوائية، جميع عينة الدراسة مقيدين في الفصول الدراسية من الصف الثالث الى الصف السادس.
ولقد أظهرت النتائج أثرا إيجابيا وتفوقا واضحا للطلبة المنتسبين لمراكز التحفيظ، وانتهت الدراسة الى مجموعة من التوصيات أهمها: زيادة عدد سور القران المقررة على الطلبة في مناهج المرحلة الابتدائية مع الحرص بان يكون معلمي التربية الإسلامية واللغة العربية من حفظة كتاب الله، وكذلك الاهتمام بإعداد محفظي القران والعمل على تطويرهم عن طريق إعداد دورات تدريبية في طرق التدريس واستخدام التقنية الحديثة. تشجيع الأطفال بجميع أعمارهم على الالتحاق بمراكز تحفيظ القران.
Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic
Authors: Mitrokhin S. D. , Aleshkin A. V. , Galitskiy A. A. , Shkoda A. S. 
Published: January 2024

A significant increase in sales of antibacterial drugs in pharmacies and their purchases by medical institutions of the Russian Healthcare System was observed against the background of the past pandemic of a novel coronavirus infection in Russia. Microbiological monitoring that was carried out at City Clinical Hospital No. 67 named after. L. A. Vorokhobov (Moscow) in 2020–2021, revealed a pressing problem — primarily gram-negative bacteria, with a predominance of multidrug-resistant (MDR) strains, were isolated from patients with healthcare-associated infections (HAIs). As shown by pharmacoeconomic studies conducted by the authors, the cost of one course of targeted antibacterial therapy for HAI in this case could increase by 6–12 times compared to a similar course of therapy in the absence of both MDR strains and XDR strains of hospital pathogens. In order to achieve a reduction in the cost of antibacterial therapy developed and used by the authors, in addition to the development of effective antibacterial therapy regimens for HAIs caused by MDR/XDR pathogens, another study was carried out as a continuation of the work on creating and improving biotherapy regimens for HAIs, namely the development of personalized phage therapy regimens for patients with hospital-acquired pneumonia caused by MDR bacterial strains. Based on the data obtained, the concept of a personalized approach to phage therapy of various nosological forms of HAIs caused by hospital-acquired MDR pathogens in patients of a multidisciplinary hospital was proposed and tested. As a result of this approach, the effectiveness of phage therapy for various nosological forms of HAIs caused by MDR and XDR strains of hospital pathogens in City Clinical Hospital No. 67 named after. L. A. Vorokhobov increased by 30%, and the effectiveness of the initial antibiotic regimen was 70%. The economic effect of the combination of antibiotic therapy and phage therapy («booster therapy») amounted to 3,000,000 rubles, compared with the use of antibiotics alone in the treatment of patients with HAIs caused by MDR/XDR strains of hospital pathogens.
Study of Molecular Parameters and Antibacterial Activity of a Peptide Preparation Derived from Human Leukocytes
Authors: Volkov A. G. , Kononova L. I. , Korobov V. P. , Volkova L. V. 
Published: January 2024

Background. The study of new antimicrobial substances isolated from the living organism tissues is of particular importance for medicine and the biopharmaceutical industry. Leukocyte peptides can act as an alternative to traditional antibiotics to overcome the bacterial antibiotic resistance problem.Aim. Evaluation of molecular weight and biological activity of ultrasound-derived leukocyte peptides.Methods. Separation of leukocyte peptide complexes into particular fractions by reverse phase chromatography and evaluation of their antibacterial activity by serial dilution and diffusion methods.Results. Studies have shown that one peptide fraction with a molecular weight of 440–570 Da has pronounced antibacterial activity.Conclusion. The obtained experimental data testify to the high therapeutic potential of the leukocyte protein-peptide complex, which has a wide spectrum of antibacterial activity.
Study of Antibacterial Drugs’ Nephrotoxicity in the RPTEC Cell Line
Authors: Evteev V. A. , Semenova I. S. , Bunyatyan N. D. , Prokofiev A. B. , Kukes V. G. 
Published: January 2024

The created cell line of human proximal renal tubules RPTEC/TERT1 showed maximum compliance with primary human RPTEC, which makes it optimal for use in studies of the nephrotoxic properties of xenobiotics. Transepithelial resistance measurement (TEER) is a valuable non-invasive method that can be used to quantify the integrity of the cell barrier at various stages of cell growth and differentiation, as well as to predict the toxicity and permeability of drugs.The aim of the study was to examine the dynamics of changes in transepithelial resistance in the model of the RPTEC/TERT1 cell line during incubation with drugs with nephrotoxic effects.Material and methods. The human proximal renal tubule cell line RPTEC/TERT was obtained from the ATCC cell culture bank. Cells at passage 14 were used in the experiment. The following drugs were studied: cisplatin: 2.5 mcg/ml; vancomycin: 50 mcg/ml; doripenem — 20mcg/ml; cefepim — 150mcg/ml. 4–5 repetitions were performed for each concentration of the drug in the experiment. THEER measurements were carried out 4–5 times for each well.Results. Cisplatin, vancomycin, doripenem, and cefepim in the concentrations used do not show a cytotoxic effect on the RPTEC cell line according to TEER dynamics.
Study of the Protective Activity of Thymogen® Dosed Nasal Spray on a Model of Experimental Influenza Pneumonia in Laboratory Animals
Authors: Zarubaev V. V. , Garshinina A. V. , Esaulkova Ya. L. , Mihalskij M. G. , Smirnov V. S. , Kudryavtseva T. A. , Petlenko S.  V. , Zaplutanov V. A. 
Published: January 2024

Introduction. Due to the ability of the influenza virus to mutate, it is necessary to constantly search for new drugs with preventive and direct antiviral effects.The aim of the study is to investigate the protective antiviral properties of the drug Thymogen®, a dosed nasal spray, on a model of lethal influenza pneumonia in laboratory animals.Material and methods. White mature mice were selected for the experiment on the antiviral activity of the tested drug samples against H1N1 influenza virus; the mice were divided into the following groups (30 animals each): two negative control groups; two groups receiving Thymogen®, a dosed nasal spray (before and after infection); one group of animals received Tamiflu®, and one received Hexoral®. The mortality of animals with influenza pneumonia was assessed; histological and morphometric analyses were also carried out.Results and discussion. The morphological picture of the lungs of animals correlated with their protective activity when analyzing the survival of animals. The normalization of tissue structure was pronounced the most in the group of animals infected with the virus, pre-incubated with Thymogen®, a dosed nasal spray, and in the group receiving Tamiflu®. Moreover, the viral load in the lungs was lower by 1.5 and 1.2 orders of magnitude in the group receiving Thymogen®, dosed nasal spray, compared to the negative control group (the 3rd and the 6th days of the experiment, respectively), which corresponds to a decrease in the intensity of viral reproduction by 31.6 and 15.8 times
Predictors of the Effectiveness of Psychological Support in Addition to the Base Treatment in Pulmonary Tuberculosis
Authors: Kolomiets V. M. , Kovalenko A. L. , Pavlenko E. P. , Petrov A. Yu. , Talikova E. V. 
Published: January 2024

The aim of the study was to investigate the effect on the psycho-emotional state and adherence to treatment in patients with pulmonary tuberculosis of remaxol inclusion in the accompanying therapy regimens.Material and methods. The data from 326 patients (252 men and 74 women) with various forms of pulmonary tuberculosis treated at the Regional Clinical Tuberculosis Dispensary were analyzed; the average age of patients was 41.3±1.6 years. A low level of adherence to treatment, as well as clinical and laboratory signs of grade I hepatotoxicity were revealed in patients receiving a course of etiotropic therapy in the main group (N=72). In this regard, in addition to the psychological support for the main course of treatment, accompanying therapy was prescribed: remaxol 400 ml intravenous drip every other day (course No. 5), after-wards — 1 time a week (course No. 4). Patients in the comparison group (N=254) received standard treatment. In addition to the standard examination, the cytokine profile (the level of IL-1β, 4, 6), TNF-α and IFN-γ) was determined in dynamics according to the indications in patients. The level of adherence to the treatment was also determined in dynamics through testing according to the original methodology.Results. The study revealed that the inclusion of remaxol in the treatment regimens facilitated more pronounced positive dynamics in clinical and laboratory data compared with the standard regimen: a decrease in signs of hepatotoxicosis and a tendency towards improvement in cytokine profile parameters. This contributed to maintaining the etiotropic therapy regimen and improving the well-being of patients, which, in turn, increased the level of adherence and therefore the effectiveness of treatment in patients.Conclusions. The combination of positive effects of remaxol use in patients with pulmonary tuberculosis contributes to an increase in their psycho-emotional state and thereby increases adherence to treatment and its effectiveness.
Clinical study of domestic ZQL-type retrievable vena cava filter
Authors: XU Ke , ZHOU Yu-bin , WANG Ai-lin , XIAO Liang 
Published: January 2024

Background
Pulmonary thromboembolism (PTE) is a serious disease often leading to disability and death. Percutaneous placement of an inferior vena cava (IVC) filter is an effective method to prevent fatal PTE caused by lower extremity deep venous thrombosis (LEDVT). We developed the ZQL-type retrievable vena cava filter. The aim of this study was to evaluate the safety and effectiveness of the ZQL-type filter for prevention of fatal PTE.

Methods
A total of 144 patients with indications for placement of an IVC filter received insertion of filters via a femoral (n=37) or jugular (n=107) vein approach. Abdominal X-ray and color Doppler ultrasonography of IVC were regularly performed to visualize the position and condition of the IVC filter following filter placement. If thrombi in the lower extremity deep veins were removed within 2 weeks, the filter retrieval procedure was performed after an abdominal radiograph, an inferior vena cavogram and a pulmonary angiography. Otherwise, the filter should be kept permanently in place with regular follow-up inspections.

Results
One hundred and forty-four filters were implanted at the target sites with a success rate of 98.61% for one-time placement and 100% for two-time placement. Of the 137 patients followed up (follow-up rate, 95.14%), 43 patients had filters retrieved during a period of between 7 and 14 days (median, 12 days) following filter placement. The remaining 94 patients were followed for 7 days to 39 months (median follow-up period, 17 months). No filter migration or tilt, filter fracture or IVC perforation was observed. No obstruction of IVC occurred. No symptomatic PTE developed during the follow-up period.

Conclusion
The ZQL-type retrievable vena cava filter is a safe and effective device to prevent PTE. This filter possesses a distinctive stent-shape, stable design, high capture efficacy, and is easy to insert and retrieve and thus is suitable for clinical application.
Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot
Authors: KONG Bo , LIU Ying-long , LÜ Xiao-dong 
Published: January 2024

Background
The molecular mechanism of human tetralogy of Fallot (TOF) is incompletely defined. Animal models have suggested that neurotrophic tyrosine receptor kinase 3 (NTRK3) might be associated with the outflow tract defect, similar to that seen in human TOF, however, the expression pattern of NTRK3 in human TOF heart tissues has never been investigated.

Methods
Quantitative real-time PCR (qRT-PCR) and immunohistochemistry were applied to detect NTRK3 mRNA and protein levels in right ventricular outflow tract tissue samples of TOF patients, ventricular septal defect (VSD) patients and normal control infants (n=10 in each group).

Results
qRT-PCR analysis indicated that NTRK3 mRNA levels were significantly decreased in the TOF group compared to the VSD group (0.024±0.003 vs 0.085±0.004, P=0.022) and the normal control group (0.024±0.003 vs 0.091±0.002, P=0.006). Quantitative immunohistochemical analysis showed that NTRK3 protein was mainly localized in the myocardium cytoplasm in all 3 groups. The immunoreactivity of NTRK3 protein was again significantly lower in the TOF group compared to the VSD group (1.42±0.62 vs 14.12±1.83, P=0.023) and the control group (1.42±0.62 vs 16.25±2.31, P=0.008). The expression of NTRK3 in the VSD group and in the control group showed no significant differences at both mRNA and protein levels.

Conclusions
Insufficient expression of NTRK3 is associated with the outflow tract defect of human tetralogy of Fallot and may contribute to the progression of this defect.
Intraoperative monitoring for safety of total hip arthroplasty using third-generation cementing technique
Authors: LI Zi-jian , ZHANG Ke , YANG Hong , LIU Yan , LÜ Jing-qiao 
Published: January 2024

Background
Controversies on the safety of the cement application between cemented and uncemented total hip arthroplasty (THA) have been existing for decades. The purpose of this study was to observe the changes in mean arterial pressure (MAP), heart rate (HR) and oxygen pressure (PaO2) during cemented THA, and to evaluate the intraoperative safety of using the third-generation cementing technique and investigate whether the intraoperative risk is higher in acute femoral neck fracture patients than non-traumatic patients.

Methods
Forty-two patients who underwent cemented THA between November 2005 and September 2007 were prospectively included in this study. The third-generation cementing technique as vacuum mixing and pulsatile lavage was used strictly. The MAP and HR were monitored and documented during each operation. Blood gas analysis was performed at exposure, cup implantation, stem implantation and wound closure. MAP, HR and PaO2 were compared between pre- and post-cement application. Comparisons of MAP, HR and PaO2 between patients with acute femoral neck fracture and non-traumatic patiens were performed as well.

Results
No intraoperative cardiopulmonary complication occurred in these cases. No obvious changes were observed in MAP, HR and PaO2 after cement application. There was no significant difference in MAP, HR and PaO2 between acute femoral fracture patients (18 patients) and non-traumatic patients (24 patients).

Conclusions
The results of this study suggested that the invasive blood pressure monitoring and blood gas analysis are essential for patients undergoing cemented THA, especially for patients with femoral neck fracture. The third-generation cementing technique is safe to use in THA.
Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury
Authors: CAO Fu-jiang , FENG Shi-qing 
Published: January 2024

Objective
To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury.

Data sources
Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline.

Study selection
Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose.

Results
Recent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies.

Conclusions
Human umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.