bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes
Authors: Barrett Alison , Shingare Manisha R. , Rechtsteiner Andreas , Wijeratne Tilini U. , Rodriguez Kelsie M. , Rubin Seth M. , Müller Gerd A. 
Published: October 2023

AbstractHistone deacetylases (HDACs) are pivotal in transcriptional regulation, and their dysregulation has been associated with various diseases including cancer. One of the critical roles of HDAC-containing complexes is the deacetylation of histone tails, which is canonically linked to transcriptional repression. Previous research has indicated that HDACs are recruited to cell-cycle gene promoters through the RB protein or the DREAM complex via SIN3B and that HDAC activity is essential for repressing G1/S and G2/M cell-cycle genes during cell-cycle arrest and exit.In this study, we sought to explore the interdependence of DREAM, RB, SIN3 proteins, and HDACs in the context of cell-cycle gene repression. We found that genetic knockout of SIN3B did not lead to derepression of cell-cycle genes in non-proliferating HCT116 and C2C12 cells. A combined loss of SIN3A and SIN3B resulted in a moderate upregulation in mRNA expression of several cell-cycle genes in arrested HCT116 cells, however, these effects appeared to be independent of DREAM or RB. Furthermore, HDAC inhibition did not induce a general upregulation of RB and DREAM target gene expression in arrested transformed or non-transformed cells. Our findings provide evidence that E2F:RB and DREAM complexes can repress cell-cycle genes without reliance on HDAC activity.
Willingness of Japanese people in their 20s, 30s and 40s to pay for genetically modified foods
Authors: Mine Akihiro , Okamoto Sawako , Myojin Tomoya , Hamada Miki , Imamura Tomoaki 
Published: October 2023

AbstractThe application of genetically modified (GM) technology to food products has increased worldwide. The adaptation has extended to conventional grains and animal products, such as salmon. However, in Japan, the public’s acceptance of GM foods is low and experts and policymakers need to know the public’s preference for various types of GM foods. Therefore, this study aims to clarify and compare the preferences for various GM foods among Japanese people in their 20s, 30s, and 40s, using the Willingness-to-pay (WTP) indicator. An online survey with 1122 valid responses from people in their 20s-40s was used for analysis. The results showed that the percentages of willingness to purchase various items were as follows – GM blue roses (n = 628; 56%), tomatoes fertilized with GM oil cake (n = 519; 46.3%), potato chips made from GM potatoes (n = 489; 43.6%), chicken thighs fed on GM corn (n = 472; 42.1%), corn flakes made from GM corn (n = 471; 42.0%), GM apples (n = 420; 37.4%), wine brewed with GM yeast (n = 416; 37.1%), GM tomatoes (n = 408; 36.4%), GM chicken thighs (n = 360; 32.1%), GM salmon (n = 349; 31.1%). Comparing the WTP discount rates for animal and plant foods, it was around 20% for animal products (GM chicken thighs = 17.8% and GM salmon = 19.5%), and 15–35% for plant foods (GM corn flakes = 24.1%, GM tomatoes = 17.2%, GM potato chips = 16.4%, GM yeast wine = 36.7%, GM apples = 25.3%). The WTP discount rates were 11.9% for tomatoes fertilized with GM oil cake compared with 17.2% for GM tomatoes, and 21.5% for GM-fed animal products compared with 17.8% for chicken thighs fed with GM corn. Therefore, the WTP values of GM animal foods were lower than GM plant foods and ornamental products.
Does Physician Over-Service Improve the Quality of Care? A Standardised Patient Audit Study
Authors: Si Yafei , Bateman Hazel , Chen Shu , Hanewald Katja , Li Bingqin , Su Min , Zhou Zhongliang 
Published: October 2023

AbstractPhysicians’ “know-do gaps” are a key factor driving the poor quality of healthcare in many developing countries, but there is little guidance on how to address these gaps. We designed a standardised patient audit study in China to evaluate the impact of physician over-service on their investment in learning and disease management decisions. We find that physicians’ total over-service leads to a 19.2%, 15.6% and 10.8% significant increase in consultation length, adherence to checklists, and patient-centred communication, respectively, but no significant improvement in giving a correct diagnosis, drug prescription or referral. The effects on physicians’ investment in learning are driven by over-service in drug prescription rather than over-service in medical tests. Moreover, over-service in drug prescription significantly leads to a 28.0 percentage-point increase in the prescription of a correct drug. Our findings imply that physician over-service reduces their “know-do gaps” and improves healthcare quality despite the related inefficient use of medical resources.JEL classificationD82; H75; I10; I11; I18; J45
Investigating the importance of surface exposed loops in the gonococcal HpuB transporter for hemoglobin binding and utilization
Authors: Awate Olivia A. , Ng Dixon , Stoudenmire Julie L. , Moraes Trevor F. , Cornelissen Cynthia N. 
Published: October 2023

ABSTRACTNeisseria gonorrhoeaeis the etiological agent of the sexually-transmitted infection gonorrhea and a global health challenge since no protective immunity results from infection and far fewer treatment options are available with increasing antimicrobial resistance. With no efficacious vaccines, researchers are exploring new targets for vaccine development and innovative therapeutics. The outer membrane TonB-dependent transporters (TdTs) produced byN. gonorrhoeaeare considered promising antigen targets as they are highly conserved and play crucial roles in overcoming nutritional immunity. One of these TdTs, the hemoglobin transport system comprised of HpuA and HpuB, allowsN. gonorrhoeaeto acquire iron from hemoglobin (hHb). In the current study, mutations in thehpuBgene were generated to better understand the structure-function relationships in HpuB. This study is one of the first to demonstrate thatN. gonorrhoeaecan bind to and utilize hemoglobin produced by animals other than humans. This study also determined that when HpuA is absent, mutations targeting extracellular loop 7 of HpuB led to defective hHb binding and utilization. However, when the lipoprotein HpuA is present, these loop 7 mutants recovered their ability to bind hHB, although their growth phenotype remained significantly impaired. Interestingly, loop 7 contains putative heme binding motifs and a hypothetical α-helical region. Taken together, these results highlight the importance of loop 7 in the functionality of HpuB in binding hHb, and extracting and internalizing iron.
The C-word: how critical cartography, critical GIS and critical data studies can repoliticise disaster-related maps
Authors: Carraro Valentina 
Published: October 2023

PurposeMapping and Geographic Information Systems (GIS) are widely used in disaster research and practice. While, in some cases, these practices incorporate methods inspired by critical cartography and critical GIS, they rarely engage with the theoretical discussions that animate those fields.Design/methodology/approachIn this commentary, the author considers three such discussions, and draws out their relevance for disaster studies: the turn towards processual cartographies, political economy analysis of datafication and calls for theorising computing of and from the South.FindingsThe review highlights how these discussions can contribute to the work of scholars engaged in mapping for disaster risk management and research. First, it can counter the taken-for-granted nature of disaster-related maps, and encourage debate about how such maps are produced, used and circulated. Second, it can foster a reflexive attitude towards the urge to quantify and map disasters. Third, it can help to rethink the role of digital technologies with respect to ongoing conversations on the need to decolonise disaster studies.Originality/valueThe paper aims to familiarise disaster studies scholars with literature that has received relatively little attention in this field and, by doing so, contribute to a repoliticisation of disaster-related maps.
Relaxed gradient-based iterative solutions to coupled Sylvester-conjugate transpose matrix equations of two unknowns
Authors: Bayoumi Ahmed M. E. 
Published: October 2023

PurposeThis article proposes a relaxed gradient iterative (RGI) algorithm to solve coupled Sylvester-conjugate transpose matrix equations (CSCTME) with two unknowns.Design/methodology/approachThis article proposes a RGI algorithm to solve CSCTME with two unknowns.FindingsThe introduced (RGI) algorithm is more efficient than the gradient iterative (GI) algorithm presented in Bayoumi (2014), where the author's method exhibits quick convergence behavior.Research limitations/implicationsThe introduced (RGI) algorithm is more efficient than the GI algorithm presented in Bayoumi (2014), where the author's method exhibits quick convergence behavior.Practical implicationsIn systems and control, Lyapunov matrix equations, Sylvester matrix equations and other matrix equations are commonly encountered.Social implicationsIn systems and control, Lyapunov matrix equations, Sylvester matrix equations and other matrix equations are commonly encountered.Originality/valueThis article proposes a relaxed gradient iterative (RGI) algorithm to solve coupled Sylvester conjugate transpose matrix equations (CSCTME) with two unknowns. For any initial matrices, a sufficient condition is derived to determine whether the proposed algorithm converges to the exact solution. To demonstrate the effectiveness of the suggested method and to compare it with the gradient-based iterative algorithm proposed in [6] numerical examples are provided.
Beyond zero-sum thinking in teacher education: cognitive science, educational neuroscience, and the history of education
Authors: Low Remy 
Published: October 2023

PurposeI take as a starting point the disparaging comments about the place of history and philosophy of education in initial teacher education (ITE) made by the chair of the Teacher Education Expert Panel established by the Australian Government in 2023, which I take to be the most recent attempt at resurrecting the tired debate over “the art versus science of teaching”. I draw on an example from my own ITE classroom to tease possibilities for how historical research and research in the sciences of learning can be in dialogue and collaborate to deepen educational scholarship.Design/methodology/approachThe purpose of this essay is to reflect on the scholarly discussions and debates in the sciences of learning that historical researchers of education have largely been absent or excluded from. I argue that historical researchers have an important role to play as “critical friends” to the burgeoning fields of cognitive science and educational neuroscience.FindingsFrom my cursory and singular account, I highlight two key areas of education where historical research and the sciences of learning can be fruitfully in dialogue and collaboration: Firstly, on the cultural dimension that prefigures learners' approach to learning; and secondly, on the factors that enable or disable effective learning.Originality/valueThis essay sets an agenda for historical researchers in education to exercise “critical friendship” with the cognitive and brain sciences of learning, specifically by adding temporal considerations to the way biology, psychology, and sociality interact to produce different educational outcomes. This will be of “practical” service to ITE – and to students in schools.
The ABC of history education: a comparison of Australian, British and Canadian approaches to teaching national and First Nations histories
Authors: Bedford Alison 
Published: October 2023

PurposeThis essay engages with scholarship on history as a discipline, curriculum documents and academic and public commentary on the teaching of history in Australian, British and Canadian secondary contexts to better understand the influence of the tension between political pressure and disciplinary practice that drives the history wars in settler-colonial nations, how this plays out in secondary history classrooms and the ramifications this may have on students' democratic dispositions.Design/methodology/approachThis article aims to compare secondary history curricula and pedagogies in Australia, Britain and Canada to better articulate and conceptualise the influence of the “history wars” over the teaching of national histories upon the intended and enacted curriculum and how this contributes to the formation of democratic dispositions within students. A conceptual model, drawing on the curriculum assessment of Porter (2006) and Gross and Terra's definition of “difficult pasts” has been developed and used as the basis for this comparison. This model highlights the competing influences of political pressure upon curriculum creation and disciplinary change shaping pedagogy, and the impact these forces may have upon students' experience.FindingsThe debate around what content students learn, and why, is fraught because it is a conversation about what each nation values and how they construct their own national identity(ies). This is particularly timely when the democratic self-identification of many nations is being challenged. The seditious conspiracy to storm the US Capitol on 6 January 2021, Orban's “illiberal democracy” in Hungary and the neo-Nazis in Melbourne, Australia are examples of the rise of anti-democratic sentiment globally. Thus, new consideration of how we teach national histories and the impact this has on the formation of democratic dispositions and skills is pressing.Originality/valueThe new articulation of a conceptual model for the impact of the history wars on education is an innovative synthesis of wide-ranging research on: the impacts of neoliberalism and cultural restorationism upon the development of intended curriculum; discipline-informed inquiry pedagogies used to enact the curriculum; and the teaching of national narratives as a political act. This comprehensive comparison of the ways in which history education in settler-colonial nations has developed over time provides new insight into the common elements of national history education, and the role this education can play in developing democratic dispositions.
The interplay of sustainability reporting and management control – an exploration of ways for dovetailing to develop reporting beyond accountability
Authors: Traxler Albert Anton , Schrack Daniela , Greiling Dorothea , Feldbauer Julia , Lautner Michaela 
Published: October 2023

PurposeCompanies must no longer just report on corporate sustainability (CS) performance but also demonstrate that they are aligning their strategies with sustainability. However, suitable management control systems (MCS) are required to implement a sustainability strategy. Thereby, sustainability reporting (SR) can also be employed for control purposes. On the other hand, existing MCS can be used to develop SR that goes beyond accountability. Accordingly, this paper explores how this interplay can be designed.Design/methodology/approachFor the study, 20 semi-structured interviews were conducted with persons from ATX and DAX companies. Since the interplay should be examined from a holistic control perspective, the authors used the MCS package of Malmi and Brown as an analysis framework.FindingsNowadays, merely focusing on reporting is too narrow a view. It is therefore not surprising that the investigation was able to reveal various possible linkages between MCS and SR that span the full range of the MCS package of Malmi and Brown.Research limitations/implicationsFuture research should also consider non-listed companies to investigate potential differences and take a closer look at the proposed reciprocal nature of the interplay.Practical implicationsThe findings expand the knowledge of how companies can use SR for control purposes and how existing MCS can help develop a reporting that goes beyond accountability.Originality/valueThe study contributes by highlighting the potential of SR to control CS performance from a holistic MCS perspective and likewise the impact of existing MCS on reporting. In addition, different theoretical perspectives are used to explain why the interplay can be designed differently in practice.
Fostering supply chain agility by prominent enablers’ identification and developing conceptual modeling based on the ISM-MICMAC approach
Authors: Can Saglam Yesim 
Published: October 2023

Purpose
Today’s marketplace has witnessed intense competitive pressures and high levels of uncertainty and disruption. Therefore, supply chains require agility to obtain a sustainable competitive advantage and cope with uncertainties as well as disruptions. Although a wide range of studies exists on supply chain agility (SCA) from the perspective of antecedents or consequences, there is little research on the investigation of enablers of SCA and their relations among them. Furthermore, the literature has investigated proactive and reactive enablers for enhancing SCA, but most studies have not sufficiently framed their analysis of both aspects synchronically. This paper aims to find out the interrelationships among the proactive and reactive enablers for enhancing SCA.

Design/methodology/approach
An extensive literature review has been conducted to identify SCA enablers and a Delphi study has been performed to elucidate SCA enablers in the manufacturing industry in Turkey. Interpretive structural modeling (ISM) has been used to identify the contextual relationship among the SCA enablers, and the model has been validated based on Matriced Impact Croises Multiplication Appliquee a un Classement (MICMAC) analysis.

Findings
On theoretical and practical levels, the proposed ISM model in this study can help organizations analyze and interpret interrelationships among enablers of SCA. For managers, it can provide better insights and understanding of the facilitators of SCA to enhance the effectiveness of the supply chain and cope with uncertainties and turbulence. According to results, enhancing “supply and demand side competency”, “delivery speed” and “strategic sourcing” are the most significant enablers of SCA.

Originality/value
The study extends the existing literature related to the enablers of SCA by modeling the proactive and reactive enablers of SCA based on the Al Humdan et al. (2020) classification. Arranging the enablers of SCA in a hierarchy and classifying the enablers into different levels with the help of the ISM-MICMAC approach is an exclusive effort to achieve successful management of the supply chain.
Investigation of herding behavior using machine learning models
Authors: Asim Muhammad , Khan Muhammad Yar , Shafi Khuram 
Published: October 2023

PurposeThe study aims to investigate the presence of herding behavior in the stock market of UK with a special emphasis on news sentiment regarding the economy. The authors focus on the news sentiment because in the current digital era, investors take their decision making on the basis of current trends projected by news and media platforms.Design/methodology/approachFor empirical modeling, the authors use machine learning models to investigate the presence of herding behavior in UK stock market for the period starting from 2006 to 2021. The authors use support vector regression, single layer neural network and multilayer neural network models to predict the herding behavior in the stock market of the UK. The authors estimate the herding coefficients using all the models and compare the findings with the linear regression model.FindingsThe results show a strong evidence of herding behavior in the stock market of the UK during different time regimes. Furthermore, when the authors incorporate the economic uncertainty news sentiment in the model, the results show a significant improvement. The results of support vector regression, single layer perceptron and multilayer perceptron model show the evidence of herding behavior in UK stock market during global financial crises of 2007–08 and COVID’19 period. In addition, the authors compare the findings with the linear regression which provides no evidence of herding behavior in all the regimes except COVID’19. The results also provide deep insights for both individual investors and policy makers to construct efficient portfolios and avoid market crashes, respectively.Originality/valueIn the existing literature of herding behavior, news sentiment regarding economic uncertainty has not been used before. However, in the present era this parameter is quite critical in context of market anomalies hence and needs to be investigated. In addition, the literature exhibits varying results about the existence of herding behavior when different methodologies are used. In this context, the use of machine learning models is quite rare in the herding literature. The machine learning models are quite robust and provide accurate results. Therefore, this research study uses three different models, i.e. single layer perceptron model, multilayer perceptron model and support vector regression model to investigate the herding behavior in the stock market of the UK. A comparative analysis is also presented among the results of all the models. The study sheds light on the importance of economic uncertainty news sentiment to predict the herding behavior.
Employment and technology: Creative creation or creative destruction? An asymmetric analysis
Authors: Irandoust Manuchehr 
Published: October 2023

AbstractTheoretical predictions of the effect of technological change on employment are ambiguous and depend on the extent to which new technology is embodied in new jobs. This paper separates positive and negative shocks and examines the extent to which technological shocks have an asymmetric effect on unemployment in nine European countries by using hidden cointegration analysis within a likelihood‐based panel framework. The findings are consistent with the hypothesis that technological changes have had an unequal effect on unemployment because negative and positive shocks have different impacts on unemployment in terms of sign and size. It is interesting to note that women appear to be the group most negatively impacted by technological shocks. The estimates also show that the results are inconsistent because technological advancement has resulted in ‘creative destruction’ in four countries while ‘creative creation’ has occurred in five of them. It is worth mentioning that the methodological framework utilized in this paper can be a useful tool for predicting the behaviour of technological shocks. Policy implications are discussed.