bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defective DNA repair: a putative nexus linking immunological diseases, neurodegenerative disorders, and cancer
Authors: Andarawi Safaa , Vodickova Ludmila , Uttarilli Anusha , Hanak Petr , Vodicka Pavel 
Published: January 2025

Abstract
DNA damage is a common event in cells, resulting from both internal and external factors. The maintenance of genomic integrity is vital for cellular function and physiological processes. The inadequate repair of DNA damage results in the genomic instability, which has been associated with the development and progression of various human diseases. Accumulation of DNA damage can lead to multiple diseases, such as neurodegenerative disorders, cancers, immune deficiencies, infertility, and ageing. This comprehensive review delves the impact of alterations in DNA damage response genes (DDR) and tries to elucidate how and to what extent the same traits modulate diverse major human diseases, such as cancer, neurodegenerative diseases, and immunological disorders. DDR is apparently the trait connecting important complex disorders in humans. However, the pathogenesis of the above disorders and diseases are different and lead to divergent consequences. It is important to discover the switch(es) that direct further the pathogenic process either to proliferative, or degenerative diseases. Our understanding of the influence of DNA damage on diverse human disorders may enable the development of the strategies to prevent, diagnose, and treat these diseases. In our article, we analysed publicly available GWAS summary statistics from the NHGRI-EBI GWAS Catalog and identified 12 009 single-nucleotide polymorphisms (SNPs) associated with cancer. Among these, 119 SNPs were found in DDR pathways, exhibiting significant P-values. Additionally, we identified 44 SNPs linked to various cancer types and neurodegenerative diseases (NDDs), including four located in DDR-related genes: ATM, CUX2, and WNT3. Furthermore, 402 SNPs were associated with both cancer and immunological disorders, with two found in the DDR gene RAD51B. This highlights the versatility of the DDR pathway in multifactorial diseases. However, the specific mechanisms that regulate DDR to initiate distinct pathogenic processes remain to be elucidated.
Effects of hydrazone-based G-quadruplex ligands on FANCJ/BRIP1-depleted cancer cells and a Caenorhabditis elegans dog-1−/− strain
Authors: Germoglio Marcello , D’Aria Federica , Cortone Giuseppe , Prodomo Antonello , Mahtab Mohammad , Morigi Rita , Amato Jussara , Pisani Francesca M , Giancola Concetta 
Published: January 2025

Abstract
G-quadruplex (G4) DNAs are alternative nucleic acid structures, proposed to play important roles in regulating DNA replication, gene transcription, and translation. Several specialized DNA helicases are involved in cellular G4 metabolism, in some cases with redundant functions. Among them, human FANCJ/BRIP1, which has orthologs in all metazoans, is one of the most powerful G4 resolvases, believed to act mainly at DNA replication forks. Here, we tested the effects of a set of hydrazone-derivative G4 ligands in a FANCJ-knocked-out HeLa cell line and in a Caenorhabditis elegans strain, where DOG-1, a FANCJ ortholog, was disrupted, as a whole organism model system. Our results revealed that loss of FANCJ specifically sensitized cancer cells to FIM-15, a mono-guanylhydrazone derivative bearing the diimidazopyrimidine core, among the tested hydrazone-based compounds and induced enhanced DNA damage in different chromosomal sites including telomeric ends. Moreover, dietary administration of FIM-15 to dog-1−/− nematodes stabilized G4 structures in gonadal cell nuclei and resulted in compromised embryonic development in the first-generation post-treatment. Collectively, our findings unveil a specific vulnerability of FANCJ-knocked-out cancer cells (and DOG-1-lacking worms) to G4 stabilization by the FIM-15 compound. This study provides an important proof-of-principle for use of G4 ligands in synthetic lethality-based therapeutic approaches targeting FANCJ-defective cancer cells.
CircPRKD3-loaded exosomes concomitantly elicit tumor growth inhibition and glioblastoma microenvironment remodeling via inhibiting STAT3 signaling
Authors: Zhang Xiaoming , Jiang Mengyuan , Niu Wanxiang , Xu Ben , Zhang Ce , Yang Minglong , Hu Shanshan , Niu Chaoshi 
Published: January 2025

Abstract

Background
Glioblastoma stem cells (GSCs) and their exosomes (exos) are involved in shaping the immune microenvironment, which is important for tumor invasion and recurrence. However, studies involving GSC-derived exosomal circular RNAs (GDE-circRNAs) in regulating tumor microenvironment (TME) remain unknown. Here, we comprehensively evaluated the significance of a novel immune-related GDE-circRNA in glioma microenvironment.

Methods
GDE-circPRKD3 was screened out through high-throughput sequencing and verified by RT-PCR, sanger sequencing and RNase R assays. A series of in vitro and in vivo experiments were performed to investigate the function of GDE-circPRKD3. RNA-seq, RNA immunoprecipitation, multicolor flow cytometry and western blotting were used to explore the regulation of GDE-circPRKD3 on STAT3 signaling-mediated TME remodeling.

Results
We have characterized a circRNA PRKD3 in GSC exosomes, and lower circPRKD3 expression predicts a worse prognosis for glioblastoma patients. Overexpression of GDE-circPRKD3 significantly impairs the biological competence of glioma and prolongs the survival of xenograft mice. GDE-circPRKD3 binds to HNRNPC in an m6A-dependent manner, accelerates mRNA decay of IL6ST and inhibits downstream target STAT3. Notably, GDE-circPRKD3 promotes CXCL10 secretion by reprogramming tumor-associated macrophages, which in turn recruits CD8+ tumor infiltrating lymphocytes against GBM. Moreover, brain-targeted lipid nanoparticle delivery of circPRKD3 combined with immune checkpoint blockade therapy achieves significant combinatorial benefits.

Conclusion
This study provides a novel mechanism by which GDE-circPRKD3 relies on STAT3 signaling to remodel immunosuppressive TME and offers a potential RNA immunotherapy strategy for GBM treatment.
Tracking Magmatism and Metasomatism in Continental Arc Crust Root: Significance from Western Central Qilian Belt in NE Tibet, China
Authors: Sun XiaoKui , Wang Chao , Scott James M , Liu Liang , Yu ZunPu , Yang WenQiang , Li Hang , Liu Ke 
Published: January 2025

Abstract
Mantle peridotites and pyroxenites from arc crust root record vital information about petrogenetic processes in supra–subduction environments, which are commonly obscured by subsequent metamorphic and/or metasomatic overprints. The Heigou Complex from the western Central Qilian arc root (NE Tibet, China) includes peridotites and pyroxenites. Petrography, bulk–rock and mineral geochemistry, zircon and titanite U–Pb ages, and bulk–rock Sr–Nd–Hf isotopes are presented to decipher its petrogenetic and metasomatic history. The peridotites display highly refractory compositions of low SiO2, Al2O3, CaO, but high MgO contents. Geochemical modeling indicates that these are the residues after up to ~22% melt extraction. The geochemical and isotopic data (87Sr/86Sr i = 0.7116–0.7179, εNd(t) = −4.2 to −7.1 and εHf(t) = −5.3 to −5.4) suggest the pyroxenitic protoliths were derived from a subduction-metasomatized mantle source. Combining petrographic and fractional crystallization simulation, the pyroxenites formed as cumulates through 50% to 80% differentiation of primitive basaltic magma in the arc root at ca. 523 Ma. Elevated LILEs (Rb, Sr, Pb, etc.) and LREE in bulk-rock and mineral compositions, together with microstructure evidence, suggest that mantle peridotite experienced mantle metasomatism. Subsequent hydrous melt (fluid) metasomatism during exhumation then reacted with the preexisting clinopyroxenite, leading to local Mg-hornblende, titanite and epidote formation. The timing of retrograde melt infiltration is constrained by a titanite U–Pb crystallization age of ca. 485 Ma. The combined evidence reveals a picture of continental arc magmatism and metasomatism at arc crust roots. Dehydration of the Proto-Tethys oceanic slab could induce flux melting in the mantle wedge that had undergone metasomatism, resulting in the generation of hydrous arc magmas. These arc magmas intruded the overlying lithospheric mantle, segregating pyroxenite cumulates. The ultramafic rocks at the arc crust root were subsequently modified by hydrous melt (fluid).
Behavior changes influence mpox transmission in the United States, 2022–2023: Insights from homogeneous and heterogeneous models
Authors: Zhang Wei , Zhang Juan , Liu Quan-Hui , Zhao Shi , Li Wei-Qiang , Ma Jun-Jie , Lu Xin , Boccaletti Stefano , Sun Gui-Quan 
Published: January 2025

Abstract
In 2022, an unprecedented mpox epidemic rapidly swept the globe, primarily transmitted through sexual contact among men who have sex with men (MSM). However, our understanding of how changes in human behavior influence this outbreak remains incomplete. In this study, we introduce a two-layer network model to investigate the impact of human behavior on mpox transmission within the United States during 2022–2023, leveraging surveillance data. We theoretically explore mpox transmission under behavioral changes using homogeneous and heterogeneous mean-field approximations. While the heterogeneous model captures differences in individual behavior, its variations do not significantly affect the overall spread, validating the feasibility of using only homogeneous models to study behavioral changes. Utilizing infection data, we exhibit the influence of behavior changes across varying transmission levels of mpox, emphasize the significant role of sexual behavior among MSM, and recommend enhancing surveillance of nonsexual cases to enable timely control of spread. Utilizing vaccination data, we demonstrate the critical impact of behavior changes on the transmission capacity of mpox virus, contrasting the limited effectiveness of vaccine campaigns. This study highlights the importance of human behavior in controlling the spread of future outbreaks, offering valuable insights for the strategic development of public health interventions aimed at mitigating such occurrences.
On corrective and distributive requirements: The case of the beneficiary pays principle
Authors: Fornaroli Giulio 
Published: January 2025

Abstract
According to the beneficiary pays principle (BPP), following an injustice that has produced damages, agents that have received benefits from it may incur a duty to redress the victim even if they are not at fault for it. In this paper, I do not offer either a full-blown defense or a refutation of the principle. Instead, I take issue with the common view, accepted by both sympathetic and critical authors, according to which the BPP is a matter of corrective justice. In the end, I am going to argue that the sole way of defending the BPP is as a principle of distributive justice. Far from a merely semantic dispute, the issue of whether the BPP is corrective or distributive is going to lead to significant normative implications regarding the sense in which we can meaningfully say that beneficiaries owe it to victims to redress the unfairness existing between them.
Parental union dissolution and children’s emotional and behavioral problems: addressing selection and considering the role of post-dissolution living arrangements
Authors: Nielsen Mikkeline Munk , Fallesen Peter , Gähler Michael 
Published: January 2025

Abstract
Increasingly children whose parents no longer live together are living in two households, alternating between family contexts. A growing literature documents strong, descriptive heterogeneities in children’s wellbeing across living arrangements. We combine longitudinal survey and administrative population data on 6000 Danish children born in 1995 to study how children’s emotional and behavioral problems change following parental union dissolution. Extending the existing, predominantly descriptive literature, we use several panel regression strategies that aim to control for unobservable confounding together with repeated measurement of the Strength and Difficulties Questionnaire to study children’s problems increase after parental union dissolution and examine heterogeneity across post-dissolution living arrangements. We find a substantial increase in emotional and behavioral problems following union dissolution, but only little evidence for substantial heterogeneity existing across post-dissolution family constellations and living arrangements. Our findings indicate that not only there is casual effect of parental union dissolution on children’s long-term wellbeing, but also that existing descriptive findings on differences across living arrangements likely are due to selection.
Social Workers’ Attitudes and Beliefs about MDMA-Assisted Therapy for Adolescents with PTSD
Authors: Mian Maha N , Horan Jordan , Hunter Taweh , Davis Alan K , Armstrong Stacey B 
Published: January 2025

Abstract
Given the widespread interest and ongoing study on MDMA-assisted therapy (MDMA-AT) for PTSD, its implications for unique populations—such as adolescents—require further understanding. Social workers will likely play a crucial role in the potential implementation of this intervention, but their perspectives remain unknown. The study includes 222 social workers randomized to read one of two vignettes about MDMA-AT or selective serotonin reuptake inhibitor–assisted therapy (SSRI-AT) for treating adolescent treatment-resistant PTSD. Participants rated each treatment’s acceptability, appropriateness, and feasibility, followed by drug stigma, perceptions of drug risk, and psychedelic knowledge. Participants in the SSRI-AT condition reported significantly higher mean ratings of treatment acceptability (p &lt; .001; d = .72), appropriateness (p &lt; .001; d = .72), and feasibility (p &lt; .001; d =. 64). In the MDMA-AT condition, perceptions of MDMA risk were greater (p &lt; .001; d = .59) and psychedelic stigma positively correlated with perceived risk of MDMA (r = .46, p &lt; .001). Moreover, greater psychedelic knowledge was significantly related to less stigma (r = –.33, p &lt; .001) and less perceived risk of MDMA (r = –.21, p &lt; .001). Concerns among social workers about the acceptability, appropriateness, and feasibility of MDMA-AT for adolescents with PTSD may limit clinical trial recruitment, engagement, and future implementation.
How to monitor the side effects of treatments in cancer patients
Authors: Di Palma Mario 
Published: January 2025

Purpose of review
Monitoring the side effects of treatments in cancer patients is a key challenge in clinical practice, especially with the development of oral therapies.
The impact on patients is multifaceted: morbidity or even life-threatening risks in the case of severe side effects; deterioration in quality of life and functional abilities; lower adherence to treatments; reduced dose intensity, which can affect the efficacy of therapies.

Recent findings
The availability of digital tools for remote patient monitoring is transforming our ability to track these patients effectively. These tools enable monitoring of a large number of patients while identifying those experiencing difficulties; early detection of side effects.

Summary
The aim of this article is to provide an overview of the use of digital tools for patient follow-up, their relevance, benefits, and the impact on both patients and healthcare organization.
Cancer-associated thrombosis: what is new?
Authors: Mahé Isabelle , Benarroch Samuel , Djennaoui Sadji , Hakem Rabiaa , Ghorbel Abdallah , Helfer Hélène , Chidiac Jean 
Published: January 2025

Purpose of review
The life expectancy of patients suffering from thrombosis associated with cancer has improved significantly, making them a chronic disease. Patients with thrombosis and cancer are fragile. Treated with anticoagulants, they remain at risk of complications.

Recent findings
Consequently, news issues emerge for clinical practice: anticoagulation therapy personalization is required to optimize the benefit ratio, involving patient characteristics and cancer characteristics. During follow-up, prediction score are designed and investigated to help identify and discriminate patients at risk of venous thromboembolism recurrences and major bleedings. Considering the improved prognosis of patients with cancer and cancer-associated thrombosis, the question of extended treatment arises, representing a major unmet need to date. Finally, new strategies, in particular anti-XI agents that appear attractive options, are currently being evaluated in the treatment of thrombosis associated with cancer.

Summary
The improved prognosis of patients with cancer-associated thrombosis is accompanied by new therapeutic strategies to improve the benefit-risk ratio of anticoagulant treatment in these fragile patients, at risk of both venous thromboembolic recurrence and haemorrhagic complication.
Guidelines on Application of Artificial Liver Blood Purification System (Version 2023)
Authors: Lanjuan Li 
Published: January 2025

Abstract
The artificial liver blood purification system (ALBPS), referred to as the artificial liver system, has been extensively used for treatment of patients with liver failure or other organ failures, and its efficacy has been well-documented. To further standardize the clinical application of ALBPS, the Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association and other institutions invited experts to update the 2016 version of ALBPS guidelines and develop the Guidelines on Application of Artificial Liver Blood Purification System (version 2023). In line with the latest international research advancements, this updated version comprehensively elaborates on various aspects of ALBPS, including treatment mode selection, anticoagulation program implementation, nursing and operational procedures, indications and relative contraindications, common complications and their management, as well as management regulations of the system. These guidelines will provide guidance for the effective application of ALBPS for treatment of critically ill patients.
Persistence and Patterns of Combat-Related PTSD, Medical, and Social Dysfunction in Male Military Veterans 50 Years After Deployment to Vietnam
Authors: Stellman Steven D. , Kaiser Anica Pless , Smith Brian N. , Spiro Avron , Stellman Jeanne Mager 
Published: January 2025

ABSTRACT

Objectives
We examined long-term patterns of PTSD and behavioral outcomes in Vietnam veterans.

Methods
A random sample of 12,400 veterans was surveyed in 1984, 1998, and a deployed subset (n = 729) in 2020. Outcomes included PTSD, psychological well-being, health functioning, and disability.

Results
Four PTSD patterns emerged over 35 years: current PTSD (9.1%, rising to 15.5% in heavy combat), prior PTSD (9.7%), sub-threshold PTSD (25.2%), and never PTSD (56.0%). A strong combat-PTSD dose-response relationship persisted across timepoints. Veterans with current PTSD showed the worst outcomes; those with sub-threshold or prior PTSD had intermediate outcomes, while never-PTSD veterans fared best. Community support mitigated adverse effects.

Conclusions
Findings highlight the enduring impact of combat, with PTSD and related dysfunction affecting veterans even below clinical thresholds, leaving many ineligible for DVA programs.
Scaffolding Case Studies
Authors: Ainslie Marcy , Hebert Danielle , Miller Joseph , Griffith Patricia B. , Moore Jeanne , Luke Sheba , Venzke Margaret Hadro 
Published: January 2025

Background:
Nursing education is transitioning to competency-based education (CBE). A key principle of CBE is scaffolding curricula from simple to complex to facilitate student learning.

Problem:
There is no standardized method of scaffolding nurse practitioner (NP) curricula.

Approach:
A workgroup of NP educators analyzed visit types—such as wellness, acute, chronic, and transition of care visits—to determine the appropriate placement of case scenarios for early, middle, or late-stage learners. Each case was then aligned with the educational preparation requirements for specific NP populations to identify which populations would benefit most from the scenario.

Outcomes:
A structured classification system, using predefined criteria, was developed to scaffold case scenarios in NP education. This systematic arrangement supports the implementation of CBE and facilitates learning.

Conclusions:
The scaffolding model can be used with a variety of learning resources and provides a standardized method for scaling complexity within NP curricula.
Validation of Tumor Budding as a Prognostic Factor in Ovarian Clear Cell Carcinoma Using an Independent Cohort
Authors: Lin Lawrence H. , Irshaid Lina , Matulonis Ursula A. , Kolin David L. 
Published: January 2025

Ovarian clear cell carcinoma (OCCC) is an endometriosis-related neoplasm, in which traditional histologic grading does not show prognostic significance. Tumor budding was associated with poorer outcomes in OCCC in previous studies. We aimed to evaluate the prognostic significance of tumor budding in OCCC in an independent cohort. Seventy patients diagnosed with OCCC were retrospectively identified. Slides from primary ovarian resections were reviewed by 2 pathologists blinded to outcomes. Tumor budding was defined as single or clusters of <5 tumor cells in peritumoral and/or intratumoral nonhyalinized stroma. Most patients were diagnosed at an early stage (stage I: 69%; II: 20%; III: 10%; IV: 1%). Twenty-one patients experienced recurrences (30%) and 2 progressive disease (3%). At the last follow-up, 52 patients had no evidence of disease, 6 were alive with disease, and 12 died of disease. The median follow-up time was 66.7 mo. Tumor budding was identified in 41 cases (59%) with a kappa coefficient of 0.60. On univariate analysis, tumor budding (P=0.022) and stage (P=0.0005) were associated with shorter progression-free survival (PFS), but only stage was independently associated with shorter PFS on multivariate analysis (P=0.003). Higher stage was the only variable associated with shorter overall survival (P=0.037). Tumor budding was associated with higher stage (P=0.039), absence of endometriosis (P=0.042) and adenofibroma (P=0.046), tumor-associated inflammation (P=0.002), and higher mitotic activity (P=0.022). There was no association between tumor budding and molecular characteristics in 32 cases with somatic tumor sequencing. Tumor budding was not independently associated with worse outcomes in this cohort of OCCC, although it was significantly associated with specific clinicopathologic features, including higher stage. Stage was the only independent variable predictive of poorer survival, which appears to drive the prognostic significance of tumor budding.