bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ANEMIA PADA REMAJA PUTRI
Authors: Zuiatna Dian 
Published: October 2023

AbstrakPendahuluan: Menurut WHO prevalensi anemia di dunia diperkirakan 1,32 miliar jiwa atau sekitar 25% dari populasi manusia di dunia. Data Riskesdas RI menunjukkan prevalensi anemia pada wanita perempuan dewasa (≥15 tahun) sebanyak 19,7% dan pada remaja (15-24 tahun) sebesar 18,4%. Tujuan: Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan kejadian anemia pada remaja di Puskesmas Babahrot Kecamatan Babahrot Kabupaten Aceh Barat Daya tahun 2020. Metode: Penelitian ini merupakan survey analtik dengan pendekatan cross sectional. Penelitian dilakukan di wilayah kerja Puskesmas Babahrot dari bulan Maret-Juli 2020. Populasi dalam penelitian ini adalah remaja putri berumur 12-15 tahun sebanyak 385 orang dan sampel 80 orang. Data diperoleh dengan menggunakan lembar observasi, analisis data terdiri dari analisis univariat dan bivariat. Analisis bivariat menggunakan uji statistik Chi Square pada α = 5%. Hasil: Hasil penelitian menunjukkan pengetahuan responden mayoritas kategori baik berjumlah 31 responden (38.8%), indeks massa tubuh responden mayoritas kategori normal berjumlah 34 responden (42.5%), dan kualitas tidur responden mayoritas kategori baik berjumlah 55 responden (68.8%). Hasil uji chi square, diperoleh nilai p value = 0,000< α 0,05, maka hipotesis diterima. Kesimpulan: Kesimpulan penelitian ini ada Hubungan Pengetahuan, IMT dan Kualitas Tidur dengan Kejadian Anemia Pada Remaja Putri di wilayah kerja Puskesmas Babahrot Kecamatan Babahrot Kabupaten Aceh Barat Daya Tahun 2020. Disarankan kepada responden agar menambah pengetahuannya tentang penyebab anemia agar mengetahui dan dapat mengendalikan faktor-faktor yang dapat menyebabkan terjadinya anemia.Kata Kunci : Pengetahuan, Indeks Massa Tubuh, Kualitas Tidur, Anemia
ANALISA FAKTOR YANG MEMPENGARUHI PERTUMBUHAN BALITA USIA 2- 4 TAHUN
Authors: Sikumbang Sri Rintani , Wardani Fina Kusuma Wardani Kusuma , Aisyah Siti Aisyah , Sinaga Hiransia 
Published: October 2023

Persentase balita usia 6-59 bulan yang ditimbang di Indonesia adalah 68,37% anak per bulan.Persentase tertinggi di Bali sebesar 84,71% dan terendah di Kalimantan Tengah sebesar 32,51%. Pertumbuhan balita dapat dilihat dari penimbangan dan pengukuran tinggi badan balita. Penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi pertumbuhan balita usia 2-4 tahun di Klinik Bidan Rosdiana Kelurahan Tanjung Mulia Kecamatan Medan Deli Tahun 2021.Metode yang di gunakan pada penelitian ini merupakan survey analitik dengan pendekatan cross sectional. Populasi sebanyak 37 balita. Sampel penelitian ini diambil dari seluruh populasi sebanyak 37 responden dengan menggunakan Accidental Sampling. Hasil penelitian ini yaitu pada 37 balita (100%) diketahui balita usia 2-4 tahun tidak sesuai dengan pertumbuhan sebanyak 13 (35,1%) dan balita usia 2-4 tahun yang sesuai dengan pertumbuhan sebanyak 24 (64,9 %). Kesimpulan dari hasil penelitian ada pengaruh pengetahuan (p value 0,002), ada pengaruh pekerjaan (p value 0,017), ada pengaruh motivasi (p value 0,015) dan tidak ada pengaruh pendidikan (p value 0,275)terhadap pertumbuhan balita usia 2-4 tahun di Klinik Bidan Rosdiana Kelurahan Tanjung Mulia Kecamatan Medan Deli Tahun 2021. Disarankan untuk tenaga kesehatan di Klinik Bidan Rosdiana Kelurahan Tanjung Mulia Kecamatan Medan Deli untuk memberikan informasi kepada ibu balita yang berkunjung ke klinik tentang pertumbuhan balita.
PENGARUH PENYULUHAN MENGGUNAKAN MEDIA LEAFLET TENTANG STUNTING TERHADAP PENGETAHUAN DAN SIKAP REMAJA PUTRI
Authors: Kinanti Baiq Meisha Indah Melia , Marliana Yunita , Suwanti Suwanti 
Published: October 2023

Organisasi Kesehatan dunia (WHO) mengestimasikan prevalensi balita kerdil (stunting) diseluruh dunia sebesar 22% atau sebanyak 149,2 juta pada tahun 2020 dan pemerintah menetapkan stunting sebagai salah satu prioritas dalam program pembangunan nasional karena stunting memiliki dampak yang berpengaruh terhadap masa depan anak apabila tidak dilakukan pencegahan sejak dini. Tujuan penelitian ini untuk menganalisa pengaruh penyuluhan menggunkan media leaflet terhadap pengetahuan dan sikap remaja putri mengenai stunting. Metode Penelitian ini menggunakan metode Pre Experimental dengan pendekatan one group pretest-posttest design. Penelitian dilaksanakan bulan Mei-Juni 2021. Populasi siswi kelas X di MA Ad Diinul Qayyim. Sampel jumlah 30 siswi Analisis data menggunakan Uji Mc Nemar dan Marginal Homogenity. Hasil Penelitian menunjukkan sebelum diberikan penyuluhan sebagian besar pengetahuan remaja putri cukup sebanyak 47%, kurang sebanyak 23% dan sikap negative sebanyak 67%, setelah diberikan penyuluhan mayoritas pengetahuan menjadi baik sebanyak 40%, cukup sebanyak 60% dan sikap menjadi positif sebanyak 77% dan negative sebanyak 23%. Berdasarkan hasil uji statistic didapatkan nilai pengetahuan (p=0,012) dan sikap (p=0,000). Adapun Kesimpulan pada penelitian ini ada pengaruh penyuluhan menggunakan media leaflet terhadap perubahan pengetahuan dan sikap remaja putri.
HUBUNGAN TINGKAT PENGETAHUAN IBU PUS TENTANG KANKER SERVIKS DENGAN PEMERIKSAAN IVA
Authors: Rale Masyuji , Kisid Kristiani Murti , Rizka Fidiya 
Published: October 2023

Introduction: According to WHO there are 530,000 new cases representing 7.5% of all cancer deaths that occur in women, and every year thousands of women die because of cervical cancer. The main strategy to reduce mortality from cervical cancer is to perform early detection. Objectif: The purpose of this study was to determine the relationship between the level of knowledge on women of childbearing age (PUS) about cervical cancer with IVA checkup in Seteluk Tengah Village, West Sumbawa Regency.Method: This study uses an analytical survey method with a cross sectional approach with the research instrument, namely a questionnaire. The study population was 789. The sample in this study was PUS women aged 15-49 years with technique cluster random sampling total of 100 samples. Data anlysis using chi-square statistical test with SPSS.Result: The results showed that the majority of respondents with high school education status were 36 people (36%) and at 17 respondents were college graduates (17%), the lowest age of respondents was 21 years and the highest was 49 years, as many as 58 respondents (58%) did IVA checkup, and 42 respondents (42%) did not do IVA checkup. Respondents with good knowledge as many as 18 people (18%) did not do IVA and 34 people (34%) did IVA checkup. It can be concluded that there is no significant relationship between the level of knowledge on women childbearing age (PUS) about cervical cancer and the IVA checkup with the results of the chi-square test p-value 0.297 (> 0,05).Conclusion: Based on these results, it is recommended that health workers can make health promotion efforts in increasing knowledge about early detection of cervical cancer and to women who are in childbearing age (PUS) are expected to continue to try to obtain information about cervical cancer and undergo IVA checkup as an effort to detect cervical cancer early.
ANALISIS FAKTOR DETERMINAN STUNTING DI NUSA TENGGARA BARAT
Authors: Handayani Baiq Nining , Setyawati Irni 
Published: October 2023

AbstrakMasalah gizi merupakan masalah kesehatan masyarakat yang terkait dengan masalah kesejahteraan masyarakat (pendidikan, sosial ekonomi, budaya dan politik). Salah satu masalah gizi di Indonesia saat ini adalah stunting. Sekitar 27 persen anak usia balita di provinsi Nusa Tenggara Barat mengalami stunting. Penelitian ini bertujuan untuk mempelajari gambaran dan determinan yang mempengaruhi stunting. Data yang digunakan adalah Riskesdas tahun 2018 dengan unit analisis anak usia balita. Analisis dilakukan dengan metode regresi logistik biner. Hasil analisis menunjukkan bahwa karakteristik anak usia balita (konsumsi makanan, pernah menderita sakit, umur); karakteristik rumah tangga (tingkat pendidikan ibu) dan lingkungan (ibu mencuci tangan dengan sabun) secara statistik signifikan mempengaruhi stunting. ANALYSIS OF STUNTING DETERMINANT FACTORS IN NUSA TENGGARA BARAT AbstractNutritional problems are public health problems related to community welfare issues (education, socio-economic, cultural and political). One of the nutritional problems in Indonesia today is stunting. Around 27 percent of children under five in the province of West Nusa Tenggara are stunted. This study aims to study the features and determinants that affect stunting. The data used is the 2018 Riskesdas with an analysis unit for children under five. The analysis was performed by binary logistic regression method. The results of the analysis show that the characteristics of children under five (consumption of food, ever suffering from illness, age); household characteristics (mother's education level) and environment (mother washing hands with soap) statistically significantly affected stunting.
SISTEM PENDUKUNG KEPUTUSAN PEMBERIAN INFRASTRUKTUR PEMBELAJARAN PASCA PANDEMI UNTUK SEKOLAH DI LINGKUP DINAS PENDIDIKAN KABUPATEN MADIUN DENGAN METODE ANALYTICAL HIERARCHY PROCESS (AHP) DAN TECHNIQUE FOR ORDER PREFERENCE BY SIMILARITY TO IDEAL SOL
Authors: Bimantara Eka Bayu , Nugrahanti Fatim , Sofyana Latjuba 
Published: October 2023

Decision Support System is a system that is used to assist in making decisions on a semi-structured type of problem, such as choosing an appropriate school to given learning infrastructure. The AHP method is a more efficient decision-making method because it presents detailed data by comparing all criteria and alternative. Calculations used to solve problem use multiplication to connect preference values, where the value for each criteria and alternative must be searched for the eigen / priority vector, after which the consistency proven using RI table (ratio index), if result proof is less than 10% (0.1) then it’s declared consistent and calculation can be continued, but if results prove more than 10% (0.1) then calculation is considered inconsistent and needs to be repeated from the beginning. As for the TOPSIS method, it’s a ranking decision against the best alternative because it calculates positive and negative ideal solutions. This support system using web base, where the data entered will be stored in MySQL database. The test results of Decision Support System for Providing Post-Pandemic Learning Infrastructure for Schools in the Madiun Regency Education Office Using Web-Based Analytical Hierarchy Process and Technique For Order Preference By Similarity To Ideal Solution Methods get results that are as expected with Black Box testing.
Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis
Authors: Bai Xiyuan , Verma Deepshikha , Garcia Cindy , Musheyev Ariel , Kim Kevin , Fornis Lorelenn , Griffith David E. , Li Li , Whittel Nicholas , Gadwa Jacob , Ohanjanyan Tamara , Eggleston Matthew J. , Galvan Manuel , Freed Brian M. , Ordway Diane , Chan Edward D. 
Published: October 2023

IntroductionA strong epidemiologic link exists between cigarette smoke (CS) exposure and susceptibility to tuberculosis (TB). Macrophage and murine studies showed that CS and nicotine impair host-protective immune cells against Mycobacterium tuberculosis (MTB) infection. While CS and nicotine may activate T regulatory cells (Tregs), little is known about how CS may affect these immunosuppressive cells with MTB infection.MethodsWe investigated whether CS-exposed Tregs could exacerbate MTB infection in co-culture with human macrophages and in recipient mice that underwent adoptive transfer of Tregs from donor CS-exposed mice.ResultsWe found that exposure of primary human Tregs to CS extract impaired the ability of unexposed human macrophages to control an MTB infection by inhibiting phagosome-lysosome fusion and autophagosome formation. Neutralizing CTLA-4 on the CS extract-exposed Tregs abrogated the impaired control of MTB infection in the macrophage and Treg co-cultures. In Foxp3+GFP+DTR+ (Thy1.2) mice depleted of endogenous Tregs, adoptive transfer of Tregs from donor CS-exposed B6.PL(Thy1.1) mice with subsequent MTB infection of the Thy1.2 mice resulted in a greater burden of MTB in the lungs and spleens than those that received Tregs from air-exposed mice. Mice that received Tregs from donor CS-exposed mice and infected with MTB had modest but significantly reduced numbers of interleukin-12-positive dendritic cells and interferon-gamma-positive CD4+ T cells in the lungs, and an increased number of total programmed cell death protein-1 (PD-1) positive CD4+ T cells in both the lungs and spleens.DiscussionPrevious studies demonstrated that CS impairs macrophages and host-protective T effector cells in controlling MTB infection. We now show that CS-exposed Tregs can also impair control of MTB in co-culture with macrophages and in a murine model.
Correlation of left atrial function and pulmonary edema in patients with left heart failure on cardiopulmonary ultrasonography
Authors: Li Hong , Hu Ping-Xiang , Chen Jian 
Published: October 2023

ObjectivePatients with heart failure with pulmonary edema may have declining left atrial (LA) function. Left atrial strain (LAS) imaging enables quantitative assessment of LA function. The aim of this prospective study was to assess the LA function and pulmonary edema in patients with heart failure evaluated by cardiopulmonary ultrasonography.MethodsTwo-dimensional speckle-tracking echocardiography for LAS was performed in 115 consecutive patients with congestive heart failure. A semiquantitative B-lines score of pleural effusions was derived by pulmonary ultrasound almost at the same time by combined cardiopulmonary ultrasound.ResultsCompared with those who did not have pulmonary edema, patients with pulmonary edema had lower LAS (LASreservoir, 21.5 ± 4.9% vs. 9.2 ± 3.7% [P &lt; 0.001]; LASconduit, 10.7 ± 3.5% vs. 5.1 ± 2.1% [P &lt; 0.001]; LASpump, 11.3 ± 5.4% vs. 4.0 ± 2.7% [P &lt; 0.001]), lower LVEF, TAPSE; and higher SPAP, E/e′, larger LA, LV, RV; more severe MR. However, there were no signiﬁcant between-group differences with respect to sex and body surface area. In patients with pulmonary edema, B-lines score was independently associated with LASreservoir (R = −0.71, P &lt; 0.001); LASpump (R = −0.66, P &lt; 0.001) and LASconduit (R = −0.56, P &lt; 0.001). On multiple linear regression, decreased LASreservoir (beta = −0.61, B = −0.71, P &lt; 0.001) and elevated SPAP (beta = 0.31, B = 0.13, P = 0.01) were significantly associated with B-lines score in heart failure.ConclusionDeclining LA function, especially the reservoir function, assessed by speckle-tracking echocardiography is related to the degree and occurrence of pulmonary edema in patients with left heart failure.
Effect of interval time between hysterosalpingography and intrauterine insemination on the pregnancy outcome of infertile patients
Authors: Ling Li , Chen Mengzhu , Shen Tao , Yang Fang , Jin Yihan , Liang Yuanjiao 
Published: October 2023

BackgroundHysterosalpingography (HSG) is the most commonly applied tubal patency test in clinical practice. Although some studies have found an increased pregnancy rate after HSG, no studies to date have specifically characterized the effect of interval time between HSG and IUI on pregnancy outcome.ObjectivesTo investigate the effect of interval time between HSG and intrauterine insemination (IUI) on live birth rates of infertile patients.MethodsRetrospective cohort study. The reproductive medical record system was used to identify patients who completed ≥1 IUI cycle between January 2017 and October 2021. According to the interval time between HSG and IUI, patients were divided into three groups: &lt;6months interval group,6-12 months interval group and &gt;12 months interval group. The generalized estimating equation with Poisson distribution was used to estimate the risk ratios (RRs) and 95% confidence intervals (CIs) of different groups.ResultsA total of 413 patients completed 701 IUI cycles during the study period, &lt;6months interval group, 415 cycles; 6-12 months interval group, 138 cycles; &gt;12 months interval group, 148 cycles. The live birth rate of &lt;6 months group was higher than other two groups (17.35% vs. 12.32% vs. 8.11%, P=0.017); Similarly, the clinical pregnancy rate of &lt;6 months group was also higher than other two groups (19.76% vs. 14.49% vs.11.49%, P=0.049). When adjusted separately for FSH, AMH, infertility type, duration of infertility, infertility diagnosis, total motile count (TMC) of sperm, medications, endometrium size and dominant follicle size, the live birth rate of &gt;12 months group severally significantly decreased by 60% (adjusted RR = 0.40, 95% CI [0.19–1.40]). The cumulative clinical pregnancy and live birth rates of &lt;6 months group were higher than other two groups (P&lt;0.05), but the cumulative pregnancy rate among three groups were not statistically different (log rank test: P=0.06).ConclusionThe interval time between hysterosalpingography and IUI is related to pregnancy outcome. The clinical pregnancy and live birth rates were the highest when the time interval was less than 6 months. Therefore, IUI should be recommend as soon as possible after HSG if the patient couple meets the IUI indication.
Effects of sleep duration and changes in body mass index on diabetic kidney disease: a prospective cohort study
Authors: Liu Cong , Zhang Jia , Wei Xing , Shi Juan , Fang Qianhua , Zhou Weiwei , Sun Lin , Hu Zhuomeng , Hong Jie , Gu Weiqiong , Wang Weiqing , Peng Ying , Zhang Yifei 
Published: October 2023

AimsTo examine the associations of sleep duration and changes in BMI with the onset of diabetic kidney disease (DKD).Materials and methods2,959 participants with type 2 diabetes were divided into three groups based on sleep duration: short (&lt;7 h/day), intermediate (7-9 h/day), or long (&gt;9 h/day). Changes in BMI during follow-up were trisected into loss, stable, or gain groups. DKD was defined as either the urinary albumin/creatinine ratio (UACR) ≥ 3.39 mg/mmol or the estimated glomerular filtration rate (eGFR) &lt; 60 mL/min/1.73m², or both. Cox regression models were used to assess hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring a mean follow-up of 2.3 years, DKD occurred in 613 participants (20.7%). A J-shaped curve was observed between sleep duration and DKD. Compared to intermediate sleep duration, long sleep duration was associated with higher risks of DKD (HR 1.47; 95% CI: 1.19-1.81). In the joint analyses, compared to participants with intermediate sleep duration and stable BMI, long sleep duration with BMI gain had the highest risks of DKD (HR 2.04; 95% CI: 1.48-2.83). In contrast, short or intermediate sleep duration accompanied by decrease in BMI was associated with a reduced risk of DKD, with HRs of 0.50 (95% CI: 0.31-0.82) and 0.61 (95% CI:0.47-0.80), respectively.ConclusionsLong sleep duration is significantly associated with an increased risk of DKD, which is further amplified by obesity or BMI gain. These findings suggest that both proper sleep duration and weight control are essential to preventing DKD.
Long amplicons as a tool to identify variable regions of ribosomal RNA for improved taxonomic resolution and diagnostic assay design in microeukaryotes: using ascetosporea as a case study
Authors: Hooper Chantelle , Ward Georgia M. , Foster Rachel , Skujina Ilze , Ironside Joseph E. , Berney Cédric , Bass David 
Published: October 2023

IntroductionThere is no universally appropriate basis for delimiting species in protists, including parasites. Many molecular markers used for species delimitation are part of the ribosomal RNA (rRNA) array, with different regions of the array being used for different parasitic protist taxa. However, little is known about sequence variability across the rRNA in most organisms, and there is no standard threshold at which divergence in the sequence of a particular gene can be used as a basis for species delimitation. MethodsHere we demonstrate a method to generate the full rRNA array of parasitic protists by amplification of the array in two long, overlapping fragments followed by Illumina and Nanopore sequencing to produce high quality assemblies, to determine variations in sequence variability across the array. We apply this approach to two pairs of closely related ascetosporean parasites of crustaceans and molluscs [respectively Paramarteilia canceri/P. orchestiae and Marteilia cochillia/M. cocosarum (Rhizaria; Endomyxa; Ascetosporea)] and Bonamia ostreae and demonstrate how full-length rRNA sequences can be used to determine regions of the rRNA array that are most discriminatory, and robustly differentiate between species in combination with other lines of evidence. ResultsPhylogenetic analyses of the transcribed regions of the rRNA array demonstrate maximal support for, and separation of, all four parasite species. Sliding window global alignment analysis determined the regions of the rRNA array that had the most consistent nucleotide differences between the closely related parasites in a 1 kb region of the array. For Paramarteilia, this region was a combined internal transcribed spacer 1-5.8S-internal transcribed spacer 2 alignment, and for Marteilia, it was the external transcribed spacer. Phylogenetic analysis of these regions were able to recover the respective species, demonstrating that these regions could be used for improved diagnostic PCR assays.DiscussionOur method could be adapted to quickly generate sequence data and determine regions more suitable for diagnostic assays for a wide diversity of parasite groups. It also allows the generation of sequence data for regions of the rRNA not commonly studied (e.g. regions of the intergenic spacer), thus enabling research into their suitability as marker regions.