bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral cavity squamous cell carcinoma and readmission: rates, causes, and risk factors
Authors: Rammal Almoaidbellah , Alqutub Abdulsalam , Alsulami Omar , Mozahim Naif , Mozahim Sarah , Awadh Mohammed , Alqutub Sadiq 
Published: February 2024

Abstract

Background
Oral cancer is a prevalent form of cancer worldwide. Unplanned readmission exposes patients to hospital-acquired complications. The readmission rate is a metric for quality of care. We aimed to identify the rate, causes, and predictors of hospital readmission within 60 days after discharge following oral cancer surgery.
Methods
This 15-year retrospective study included all patients who underwent oral oncologic surgery at a single tertiary center between 2008 and 2023. Patient charts were reviewed for demographic information, comorbidities, and causes for readmission.
Results
Of the 93 patients who underwent oral oncologic surgery, nine (9.70%) were readmitted within 60 days after discharge. The most common reason for readmission was surgical site infection (33.33%), followed by wound bleeding (25%). The significant predictors were unmarried status (P = 0.003), T4 disease status (P = 0.004), a higher cumulative illness rating scale (CIRS) (P = 0.011), radical excisions (P = 0.028), a higher American Society of Anesthesiology (ASA) score (P = 0.029), a lower preoperative serum albumin (P = 0.028), and a greater neutrophil count (P = 0.03).
Conclusion
One in every ten patients was readmitted following oral cancer surgery. The most common cause is surgical site infection. Significant predictors included T4 disease, preoperative hypoalbuminemia, higher neutrophil counts, unmarried status, extensive surgery, and higher baseline comorbidity indices. Future guidelines to lower readmission rates should focus on high-risk patients and involve earlier follow-up, more rigorous postdischarge monitoring, and delayed discharge.
Deep Learning-Based Small Sample Body Vein Recognition and Its Implementation
Authors: Tang Chaoying , Prasad Shitala , Zhang Yufeng 
Published: February 2024

Abstract
In scenarios like forensic investigations, only RGB images of body parts, especially limbs, are available from surveillance. Traditional biometric methods like face, fingerprints, and iris scans are not applicable in such cases. Additionally, hand veins, typically captured using NIR imaging, are not accessible either. To address this challenge, body vein recognition technology has been introduced. Different techniques have been proposed to uncover and extract vein patterns from RGB images. However, handcrafted features are sensitive to image noise, and deep learning methods require extensive training data, which is lacking in forensic investigations. In this study, we presented a small-sample body vein recognition approach based on deep learning. A data augmentation method utilizing Gabor filtering and vein line traction was introduced to enhance generalization performance and tackle the limitation of training samples. A new model combining improved DenseNet and Arcface loss was developed for body vein recognition. Furthermore, a feature retrieval scheme based on binary hash coding was introduced to optimize recognition accuracy and retrieval efficiency. Experimental results using images from 250 forearms and 230 thighs demonstrated the superiority of our small-sample body vein recognition method over other matching techniques. Ablation studies confirmed the effectiveness of the data augmentation and feature retrieval schemes. Finally, the model was deployed on a portable system, leading to the implementation of a contactless body vein recognition system.
Cordycepin: A Molecular Trojan Horse Against Fusarium oxysporum f. sp. cubense - A Computational Perspective
Authors: Showkat Mansoor , Nagesha N , Ashraf Suhail , Nayana Krishna , Bashir Shahida , Nair Athulya S , Hussain Abid , Krishnan Priya , V Rajesh R 
Published: February 2024

Abstract

Fusarium oxysporumis a notorious plant pathogen responsible for devastating losses in agricultural and horticultural crops worldwide. To combat the economic and ecological challenges posed by this pathogen, there is a pressing need for novel antifungal agents. Cordycepin, a natural compound derived from Cordyceps species, has exhibited promising antifungal properties against various pathogens. In this study, we employed molecular docking techniques to investigate the potential inhibitory activity of cordycepin against three critical proteins inFusarium oxysporum f. sp. cubense(Foc) SIX13, Fosp9, and FocTR4. Through computational analysis, we elucidated the binding interactions between cordycepin and these target proteins. Our results revealed that cordycepin can effectively dock into the active sites of SIX13, Fosp9, and FocTR4, forming stable complexes with favorable binding energies. These interactions involve key amino acid residues crucial for the biological function of these proteins. Furthermore, we explored the binding modes and potential hydrogen bond interactions, shedding light on the mechanisms through which cordycepin may disrupt the function of these vital proteins inFusarium oxysporum. These findings provide valuable insights into the potential of cordycepin as a novel antifungal agent targeting specific proteins inFusarium oxysporum, which could pave the way for the development of innovative strategies for managing this devastating plant pathogen and mitigating its impact on global agriculture. Further experimental validation and in vivo studies are warranted to confirm the therapeutic potential of cordycepin in controllingFusarium oxysporuminfections.
Effects of Erythropoietin on Cardiac Morphometry in Exercised Adolescent Rats
Authors: Ates Mehmet Burak , Akcakavak Gokhan , Ozdemir Ozgur , Ozdemir Mehmet , Bozkurt Ibrahim 
Published: February 2024

Abstract
Erythropoietin (EPO) is a glycoprotein hormone primarily synthesised in the kidneys. Its main function is to stimulate the proliferation and maturation of erythroid cells in the bone marrow. Although EPOs are prominent with their anti-inflammatory, anti-oxidant, anti-apoptotic and angiogenic effects in addition to anaemia treatment, they are sometimes used by athletes for doping purposes. In the present study, the morphometric effects of EPO on the hearts of exercised adolescent rats were investigated. In the four-week study, 48 40-day-old rats were divided into four main groups: Control, Swimming exercise, Drug, and Swimming + Drug, and eight subgroups based on sex. The control group received intraperitoneal (IP) saline four times a week, while the swimming exercise group received 30 minutes of swimming exercise in addition to saline. The drug control group was administered with epoetin alfa (50 IU/kg, IP, four times a week), while the Swimming + Drug group received 30 minutes of swimming exercise after drug administration. The measurements taken after the study showed that EPO administration did not cause significant changes in important parameters for left ventricular hypertrophy. However, the study found that EPO-treated females exhibited acute cardiac dilatation, which was characterized by thinning of the right heart wall and interventricular septum due to intraventricular haemoconcentration. In conclusion, left heart hypertrophy was not detected morphologically with short-term exercise and EPO administration, but findings that may affect cardiac functions and even progress to hypertrophic cardiomyopathy were observed.
Research on Optimization Design Method of Building Structure Based on Genetic Algorithm
Authors: Zhou Yu 
Published: February 2024

Abstract
Building structural design is a complex process essential for producing safe, functional and visually stunning procedures. An additional important aspect of this design strategy is the choice of building materials and techniques. Ensuring that the chosen materials follow the building's goals requires considering variables including the availability of materials, economics and structural integrity. The current developments in the use of algorithms in the field of building structural design and performance evaluation are examined in this study. Different model architectures may be appropriate for training datasets with particular feature sets. Daily weather profiles in the history database contain a variety of characteristics. A collection of rules for development-based feature extraction allows the use of Restricted Boltzmann Machines (RBM). The study demonstrates how Genetic Algorithms (GA) operators work on potential converting solutions, while the concept could include member and structure-level approaches. The findings indicate that 97% of the localization accuracy is categorized. To evaluate the recommended classification technique, five distinct construction types (concrete sheer wall, steel, brick masonry, concrete frame and concrete frame-sheer wall) were categorized using the precision, recall and F1-score evaluation criteria. When the suggested approach is contrasted with existing algorithms, our method produces sufficient findings.
Non-Crohn's complex and multirelapsed perianal fistulas treated with sphincter sparing surgical procedures and adjuvant adipose tissue injection
Authors: Guillaumes Salvador , Hidalgo Nils Jimmy , Bachero Irene , Pena Romina , Tavares Sara , Ardid Jordi , Pera Miguel 
Published: February 2024

Abstract
Purpose
The purpose of this study was to evaluate the results obtained by the treatment of non-Crohn’s-related complex and multirelapsed perianal fistulas using a surgical sphincter-sparing technique with adjuvant adipose tissue injection, a rich source of progenitor and immunomodulatory cells.
Methods
A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2020 to December 2022. Nine patients were enrolled and assessed after a minimum of twelve months of follow-up. All patients underwent removal of the setons, excision, or curettage of the fistula tract and mucosal flap or internal opening suture. The collection and processing of adipose tissue to be injected was performed using a commercially available system.
Results
Selected cases included six men and three women with a mean age of 42. All patients had an extended disease course period, ranging from 3 to 13 years (mean 6.6 years), and a history of multiple previous surgeries, including two to eight interventions (an average of 4.4 per case). All fistulas were high transsphincteric, in four cases in horseshoe and two cases with secondary suprasphincteric or peri-elevator tract fistulas. At a mean follow-up of 18 months (range 12–36), a complete healing rate was documented in six cases (66%) and a remarkable improvement in three cases (33,3%).
Conclusions
In the group of patients described with complex fistulas with multiple recurrences, many from palliative treatments with setons, the adjuvant injection of adipose tissue associated with a sphincter-sparing surgical procedure might help to achieve closure or improvement in a significant percentage of cases.
The study protocol was prospectively registered on Clinicaltrials.gov (NCT 04750499).
UVB-aged microplastics and cellular damage : An in vitro study
Authors: MAESTRA SEBASTIANO LA , Benvenuti Mirko , Alberti Stefano , Ferrea Linda , D'Agostini Francesco 
Published: February 2024

Abstract

Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of Reactive Oxidative Species (ROS), as indicated by the increased malondialdehyde (MDA) level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk.
In-silico investigation on the discovery of synthesized nucleoside-based antivirals against monkeypox and SARS-CoV-2 Virus
Authors: Balasubramaniyam Thananjeyan , Sreek Aparna Ganapathy Vilasam , Nathan Vinod Kumar , Rampogu Shailima 
Published: February 2024

Abstract
The monkeypox virus and the SARS-CoV-2 virus serve as illustrative instances of agents that give rise to outbreaks. In the current study, we sought new broad-spectrum nucleoside-based antivirals that target viral particle attachment and target cell penetration. We used virtual molecular docking tools to assess the binding capability of the synthesized nucleoside-based medicines to the surface viral proteins and cell receptors. The results showed that the nucleoside-based antiviral drugs bounded well with the primary protease of SARS CoV-2 Mpro (PDB ID: 6LU7) and A42R Profilin-like protein of monkeypox virus (PDB ID: 4QWO). The interaction scores were observed to be of -7.82 kcal/mol by 8-amino G for 6LU7 and -7.95 kcal/mol by 8-Bromo A for 4QWO. The ligands tested were found to have high gastrointestinal absorption, with no blood-brain barrier permeability. The binding mode analysis revealed that most of the peptides that showed high interaction score were non-mutagenic but were found to be developmental toxicant. These compounds can be taken into consideration in the future for additional optimization and in-vitro experimental validation for the development of anti-susceptible drugs and vaccines.
Examining the effectiveness of Mozart's music on reading and writing performance of pupils in a Nigerian elementary school.
Authors: OLUWAFEMI AKINTADE 
Published: February 2024

Abstract
This research study aims to investigate how Mozart's music impacts the reading and writing performance of primary school children in Nigeria. The study spanned six weeks and involved thirty children aged six to ten, whose reading and writing abilities were assessed. The participants were divided into two groups: an experimental group of fifteen children received English language lessons and test accompanied by Mozart's music as background for one month and two weeks, while the remaining fifteen children formed the control group and received similar lessons and test without the music. To evaluate the effect of background music, a t-test was conducted to compare the performance of the experimental and control groups in reading comprehension and writing tasks, both with and without M ozart's music. The results showed a statistically significant difference between the two groups, suggesting that integrating Mozart and classical music into learning could be an effective strategy for enhancing literacy development through improved reading comprehension and writing skills. This research contributes to the current understanding of the correlation between music and cognitive development, with a specific focus on literacy. It centers on primary school children in Nigeria and seeks to address a notable gap in the existing literature. While previous studies have predominantly examined the influence of Mozart's music on reading abilities, the writing aspect of language skills has received limited attention. By exploring this unexplored territory, the study aims to shed light on the advantages of integrating music into classroom learning and its potential to enhance students' motivation to learn.
Study Approaches of Campus-Based and Distance Learning Undergraduates during Emergency Remote Teaching Amid the COVID-19 Pandemic in India
Authors: SANWAL ANJU 
Published: February 2024

Abstract
One of the significant dimensions of learning design for quality student learning is the student approach to study and their learning strategies. This assumption assumes considerable importance, especially in the contemporary context of the COVID-19 pandemic and the sudden switch to remote teaching-learning. The situation is more vulnerable in developing countries where both campus and distance learning students were compulsorily involved in this new form of learning. The present study was undertaken to determine whether there were any significant differences in undergraduate students’ approaches to learning or learning strategies, or in age, sex, or mode of delivery while undertaking home study at the time of the pandemic in India. The revised version of the Study Process Questionnaire (R-SPQ-2F) was administered to 208 randomly selected undergraduate students studying at two campus-based central universities (n = 92) and one national open university (n = 116) in the national capital Delhi. The results showed that distance learning and female students adopted more deep approaches to study than did the campus students and male students respectively. In both delivery contexts, the female students had greater intrinsic motivation and used more of a deep approach to learning than did their male counterparts. The results of this study have been discussed in relation to previous studies on the student approach to study. There are also implications for national and institutional policy and the practice of teaching-learning in higher education.
Climate change and farmers' perception in Sivakasi taluk, India: a nexus and a suggestion for sustainable water reuse
Authors: Baanu B. Bharani , Babu K. S. Jinesh 
Published: February 2024

Abstract
Climate change poses a major threat to agriculture and food security, especially in developing countries where farmers depend on rainfall and groundwater for irrigation. This paper investigates how farmers in Sivakasi taluk, Tamil Nadu, India perceive and respond to climate change – rainfall and temperature – and its impacts on agriculture. Actual rainfall and temperature data are analyzed using Mann–Kendall test and Sen's slope estimator test, and the results are compared against the farmers' perceptions obtained through a questionnaire survey. The trend analysis showed an insignificant decrease in rainfall and a significant increase in temperature. Most farmers perceived rainfall change correctly, but not temperature change. It is found that water scarcity is a major challenge for agriculture due to reduced rainfall, increased temperature, and inadequate adaptations. To address this challenge, water reuse is proposed as a sustainable alternate adaptation that involves using treated wastewater (TWW) from a decentralized sewage treatment plant for irrigation. An index named Water Reuse Index (WRI) is developed to estimate the fraction of TWW that can replace freshwater irrigation. This study provides insights into farmers' perception of climate change and suggests a novel way to enhance water security and resilience in agriculture.
Modulation of the HIF-1α-NCOA4-FTH1 Signaling Axis Regulating
Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the
Anti-hepatic Fibrosis Mechanism of Curcumol
Authors: Zheng Yang , Wang Lei , Wang Jiaru , Zhao Tiejian , Wang Jiahui 
Published: February 2024

Introduction:
Senescence of activated hepatic stellate cells (HSC) reduces extracellular
matrix expression to reverse liver fibrosis. Ferroptosis is closely related to cellular
senescence, but its regulatory mechanisms need to be further investigated. The iron
ions weakly bound to ferritin in the cell are called labile iron pool (LIP), and together
with ferritin, they maintain cellular iron homeostasis and regulate the cell's sensitivity to
ferroptosis.

Methods:
We used lipopolysaccharide (LPS) to construct a pathological model group
and divided the hepatic stellate cells into a blank group, a model group, and a curcumol
12.5 mg/L group, a curcumol 25 mg/L group, and a curcumol 50 mg/L group. HIF-1α-NCOA4-
FTH1 signalling axis, ferroptosis and cellular senescence were detected by various
cellular molecular biology experiments.

Result:
We found that curcumol could induce hepatic stellate cell senescence by promoting
iron death in hepatic stellate cells. Curcumol induced massive deposition of iron
ions in hepatic stellate cells by activating the HIF-1α-NCOA4-FTH1 signalling axis,
which further led to iron overload and lipid peroxidation-induced ferroptosis. Interestingly,
our knockdown of HIF-1α rescued curcumol-induced LIP and iron deposition in hepatic
stellate cells, suggesting that HIF-1α is a key target of curcumol in regulating iron
metabolism and ferroptosis. We were able to rescue curcumol-induced hepatic stellate
cell senescence when we reduced LIP and iron ion deposition using iron chelators.

Conclusion:
Overall, curcumol induces ferroptosis and cellular senescence by increasing
HIF-1α expression and increasing NCOA4 interaction with FTH1, leading to massive
deposition of LIP and iron ions, which may be the molecular biological mechanism
of its anti-liver fibrosis.
Design and Fabrication of Silver Nanoparticles Doped β-cyclodextrin-chitosan
Functionalized Graphene Nanocomposite Modified Electrode for
Determination of Cu(II)
Authors: Akhdhar Abdullah , Binkadem Mona Saad , El-Said Waleed Ahmed , Yakout Amr A. 
Published: February 2024

Introduction:
In this study, a nanocomposite film was prepared by doping silver nanoparticles
onto β-cyclodextrin-chitosan functionalized Reduced Graphene Oxide (RGO), denoted as Ag/
β-CD/CS/G nanocomposite. The average diameter of the Ag NPs was found to be 62±17 nm.

Methods:
The fabricated composite was applied to monitor trace levels of copper ions in different
industrial and environmental water samples. The morphology and microstructure of the fabricated
sensor were extensively investigated using different techniques, including XRD, TGA, HR-TEM,
FTIR, SEM, XPS, and EDX physicochemical techniques. For the electrochemical monitoring of
Cu(II), the Ag/β-CD/CS/G nanocomposite electrode showed remarkable performance in terms of
high sensitivity and a low limit of detection that was found to be 0.24 nmol L-1.

Results:
The developed sensors showed a linear dynamic range from 10-3 to 10-8 mol L-1 with an R2
of 0.99. The impacts of different electrochemical parameters, including medium pH, scanning rate,
and interfering ions, were investigated.

Conclusion:
Furthermore, the fabricated modified electrode showed high efficiency for Cu(II) detection
in groundwater samples.