bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of supermountain belts and climatic controls on the genesis of copper deposits in the Kupferschiefer and the Central African Copperbelt
Authors: Squire Richard J. , Keays Reid R. 
Published: November 2023

AbstractSedimentary rock–hosted stratiform copper deposits are the world’s second largest source of copper and the largest source of cobalt, with about 73% of the copper occurring in two basins: the Katangan Basin (Central African Copperbelt) and the Permian Basin (Kupferschiefer). Why these two sedimentary basins are so highly endowed in copper is puzzling because sedimentary rock–hosted stratiform copper deposits have formed since the Paleoproterozoic and they all share remarkably similar ore mineralogy, host-rock characteristics and basin settings. We suggest that this discrepancy is due to the development of these two basins close to the bases of ~ 8000-km-long supermountain belts. The supermountain belts were instrumental in raising oxygen levels in Earth’s atmosphere, as well as providing a voluminous source of groundwater and a powerful and long-lived driver for the fluid-flow system. The elevated oxygen levels facilitated the diagenetic processes that converted copper-bearing labile minerals to amorphous iron-oxides and smectite and then in turn to hematite and illite. When oxidized brines flushed through the basin successions, the liberated copper was transported to units containing carbon-rich mudstone and the metals were deposited. For the Katangan Basin, development of the Transgondwanan supermountain belt along its margins between about 525 and 510 Ma explains the delay of several hundreds of millions of years between basin formation and mineralization in the Central African Copperbelt. In contrast, development of the Mid-Pangean supermountain belt formed penecontemporaneous with the Permian Basin explains the similarity in timing between basin formation and mineralization in the Kupferschiefer.
A case study of hybrid manufacturing of a Ti-6Al-4V titanium alloy hip prosthesis
Authors: Festas António José , Figueiredo Daniel Amaral , Carvalho Sílvia Ribeiro , Vo Thang Hoang , Doutre Pierre-Thomas , Villeneuve François , Ramos António Manuel , Davim João Paulo 
Published: November 2023

AbstractHybrid manufacturing (HM) is a process that combines additive manufacturing (AM) and subtractive manufacturing (SM). It is becoming increasingly recognized as a solution capable of producing components of high geometric complexity, while at the same time ensuring the quality of the surface finish, rigour and geometric tolerance on functional surfaces. This work aims to study the surface finish quality of an orthopaedic hip resurfacing prosthesis obtained by HM. For this purpose, test samples of titanium alloy Ti-6Al-4V using two Power Bed Fusion (PBF) processes were manufactured, which were finished by turning and 5-axis milling. It was verified that, upon the machining tests, no differences in Ra and Rt were found between the various types of AM. Regarding the type of SM used, 5-axis milling provided lower roughness results with a consistent value of Ra = 0.6 µm. The use of segmented circle mills in 5-axis milling proved to be an asset in achieving a good surface finish. This work successfully validated the concept of HM to produce a medical device, namely, an orthopaedic hip prosthesis.As far as surface quality is concerned, it could be concluded that the optimal solution for this case study is 5-axis milling.
The evolution of the natural rate of interest: evidence from the Scandinavian countries
Authors: Armelius Hanna , Solberger Martin , Spånberg Erik , Österholm Pär 
Published: November 2023

AbstractIn this paper, the natural rate of interest in Denmark, Norway and Sweden is estimated. This is done by augmenting the Laubach and Williams (Rev Econ Stat 85:1063–1070, 2003) framework with a dynamic factor model linked to economic indicators––a modelling choice which allows us to better identify business cycle fluctuations. We estimate the model using Bayesian methods on data ranging from 1990Q1 to 2022Q4. The results indicate that the natural rate has declined substantially and in all countries is at a low level at the end of the sample.
Pharmacological update of mirtazapine: a narrative literature review
Authors: Hassanein Emad H. M. , Althagafy Hanan S. , Baraka Mohammad A. , Abd-alhameed Esraa K. , Ibrahim Islam M. 
Published: November 2023

AbstractMirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It also has an excellent safety and tolerability profile. The present review provides a pharmacological update on MTZ and summarizes the research findings of MTZ’s effects on different diseases. MTZ is hypothesized to have antidepressant effects because of the synergy between noradrenergic and serotonergic actions and is effective in treating major depressive disorder and depression associated with epilepsy, Alzheimer’s disease, stroke, cardiovascular disease, and respiratory disease. In cancer patients, MTZ significantly reduced sadness, nausea, sleep disruption, and pain and improved quality of life. Also, it has promising effects on Parkinson’s disease, schizophrenia, dysthymia, social anxiety disorder, alcohol dependency, posttraumatic stress disorder, panic disorder, pain syndromes, obsessive–compulsive disorder, and sleep disorders. Additionally, MTZ is potentially therapeutic in different situations associated with depression, such as liver, kidney, cardiovascular, respiratory, infertility, heavy metal-induced neurotoxicity, and pruritus. Potent antioxidative, anti-inflammatory, and anti-apoptotic bioactivities mediate these promising effects. These positive outcomes of the scientific investigations motivate more and more clinical trials for a golden exceptional antidepressant in different conditions.Graphical Abstract
A smartphone aptasensor for fipronil detection in honey samples
Authors: Svigelj Rossella , Dassi Noemi , Gorassini Andrea , Toniolo Rosanna 
Published: November 2023

Abstract In this study, an electrochemical smartphone-based aptasensor for the determination of fipronil was developed by modifying a screen-printed carbon electrode (SPCE). Fipronil is a broad-spectrum insecticide that has been widely used in various applications such as agriculture, veterinary, and household pest control. Recently, its use has raised concerns over the potential impact on the environment and human health. The absence of effective methods for this purpose poses a significant obstacle. To tackle this problem, we have developed a cutting-edge aptamer-based portable sensor capable of rapidly and conveniently detecting fipronil in situ. Considering that the detection of small molecules, such as fipronil, can be a challenging task, a competitive replacement assay was set up based on the aptamer’s preference for the free form of fipronil over the immobilized one on the electrode. The analytical performance provided by the sensor on standard solutions of a known fipronil content made it possible to estimate a limit of detection (LOD) equal to 1.07 μg kg−1 and a limit of quantification (LOQ) of 3.21 μg kg−1. Selectivity tests were conducted using atrazine as a possible interferent. The use and performance of the developed portable aptasensor was assessed on honey samples, which were simultaneously analyzed using an HPLC–MS method. This aptasensor could be an affordable and effective tool for accurately quantifying fipronil not only in honey samples but also in other food products.
Graphical abstract
Joint line position change in primary total knee arthroplasty: a radiographic analysis comparing conventional and robotic techniques
Authors: Cozzarelli Nicholas F. , DeSimone Cristian A. , D’Amore Taylor , Sherman Matthew B. , Lonner Jess H. 
Published: November 2023

Abstract
Purpose
Joint line (JL) position change in total knee arthroplasty (TKA) may alter knee biomechanics and impact function. The purpose of this study was to compare the change in JL position between robotic-assisted TKA (RA-TKA) and conventional TKA (C-TKA).

Methods
A retrospective, radiographic analysis was conducted of patients who underwent RA-TKA and C-TKA to compare JL position change. JL position was measured in consecutive RA-TKAs and C-TKAs performed by four fellowship-trained arthroplasty surgeons. Statistical analysis was done utilizing t-tests and Mann Whitney U tests, with statistical significance being defined as a p value < 0.05.

Results
Six hundred total RA-TKAs and 400 total C-TKAs were included in the analysis. There were no significant differences in patient baseline characteristics such as body mass index, range of motion, and tibiofemoral coronal alignment. RA-TKAs were associated with an average of 0.04 (2.2) mm JL position change, and C-TKAs were associated with an average 0.5 (3.2) mm JL position change (p = 0.030). There were inter-surgeon differences when comparing the change in JL position for RA-TKAs and C-TKAs between the four participating surgeons.

Conclusion
RA-TKA leads to better preservation of the JL position than C-TKA, and this seems to be dependent on the arthroplasty surgeon’s preferences and techniques during TKA. Whether this statistically significant difference is clinically relevant needs to be further investigated.
Enhanced photocatalytic properties of graphene oxide/polyvinylchloride membranes by incorporation with green prepared SnO2 and TiO2 nanocomposite for water treatment
Authors: Mousa Sahar A. , Abdallah Heba , Ibrahim S. S. , Khairy S. A. 
Published: November 2023

AbstractPhotocatalytic membranes (PMR) have significant potential for utilization in energy-efficient water purification and wastewater treatment. The integration of membrane filtration's physical separation with photocatalysis's organic degradation is facilitated by their respective capabilities. In the present study, a more advanced graphene oxide (GO) membrane with improved photocatalytic properties was developed. This was achieved by incorporating tin dioxide (SnO2) and titanium dioxide (TiO2) nanoparticles (NPs) into a polyvinyl chloride (PVC) matrix, resulting in the fabrication of a microfiltration flat sheet membrane. The hydrophilicity of the membrane surface was investigated. The existence of NPs on membrane surfaces was demonstrated by FESEM images, Raman spectra, and FT-IR measurements. The porosity was affected by the addition of NPs; it increased from 59 to 76, and 92 for GO/TiO2, and GO/SnO2 respectively. The relationship between photocatalysis and filtration was investigated. Each nanocomposite membrane displayed a greater water flux and removal efficiency than a blank PVC membrane. Whereas the water flux enhanced from 1.3 to 17.6, and 20.5 for GO/TiO2, and GO/SnO2 respectively. Sunlight improves water flow and rejection compared to darkness. This research provides an alternative and highly efficient photocatalytic membrane for removing organic compounds from water, as the GO/SnO2 nanocomposites membrane exhibits the highest photocatalytic degradation up to a rejection rate of 98% when compared to an unmodified membrane.
The acute vestibular syndrome: prevalence of new hearing loss and its diagnostic value
Authors: von Werdt Moritz , Korda Athanasia , Zamaro Ewa , Wagner Franca , Kompis Martin , Caversaccio Marco D. , Mantokoudis Georgios 
Published: November 2023

Abstract
Objectives
To assess the prevalence of new hearing losses in patients with acute vestibular syndrome (AVS) and to start to evaluate its diagnostic value for the differentiation between peripheral and central causes.

Design
We performed a cross-sectional prospective study in AVS patients presenting to our Emergency Department (ED) from February 2015 to November 2020. All patients received an MRI, Head-impulse test, Nystagmus test and Test of skew (‘HINTS’), caloric testing and a pure-tone audiometry.

Results
We assessed 71 AVS patients, 17 of whom had a central and 54 a peripheral cause of dizziness. 12.7% had an objective hearing loss. ‘HINTS’ had an accuracy of 78.9% to diagnose stroke, whereas ‘HINTS’ plus audiometry 73.2%. ‘HINTS’ sensitivity was 82.4% and specificity 77.8% compared to ‘HINTS’ plus audiometry showing a sensitivity of 82.4% and specificity of 70.4%. The four patients with stroke and minor stroke had all central ‘HINTS’. 55% of the patients did not perceive their new unilateral hearing loss.

Conclusions
We found that almost one-eighth of the AVS patients had a new onset of hearing loss and only half had self-reported it. ‘HINTS’ plus audiometry proved to be less accurate to diagnose a central cause than ‘HINTS’ alone. Audiometry offered little diagnostic accuracy to detect strokes in the ED but might be useful to objectify a new hearing loss that was underestimated in the acute phase. Complete hearing loss should be considered a red flag, as three in four patients suffered from a central cause.
Targeting sleep and the circadian system as a novel treatment strategy for Parkinson’s disease
Authors: Feigl Beatrix , Lewis Simon J. G. , Rawashdeh Oliver 
Published: November 2023

AbstractThere is a growing appreciation of the wide range of sleep–wake disturbances that occur frequently in Parkinson’s disease. These are known to be associated with a range of motor and non-motor symptoms and significantly impact not only on the quality of life of the patient, but also on their bed partner. The underlying causes for fragmented sleep and daytime somnolence are no doubt multifactorial but there is clear evidence for circadian disruption in Parkinson’s disease. This appears to be occurring not only as a result of the neuropathological changes that occur across a distributed neural network, but even down to the cellular level. Such observations indicate that circadian changes may in fact be a driver of neurodegeneration, as well as a cause for some of the sleep–wake symptoms observed in Parkinson’s disease. Thus, efforts are now required to evaluate approaches including the prescription of precision medicine to modulate photoreceptor activation ratios that reflect daylight inputs to the circadian pacemaker, the use of small molecules to target clock genes, the manipulation of orexin pathways that could help restore the circadian system, to offer novel symptomatic and novel disease modifying strategies.
Implant-supported crowns on maxillary laterals and canines—a long-term follow-up of aesthetics and function
Authors: Sanatnama Elnaz , Frantz Lena , Ahlin Erik , Naoumova Julia 
Published: November 2023

Abstract
Objectives
To assess the long-term aesthetic and functional aspects of implant-supported crowns in lateral (ISC-L) and canine positions (ISC-C).

Materials and methods
Thirty-two patients (14 males, 18 females, mean age: 23.1, SD:2.0) with an ISC-L or ISC-C participated in this prospective cohort study at baseline (T0) and in the long-term follow-up (T1, mean years: 11.1, SD: 1.0). Twenty-four patients (11 males, 13 females) participated in T1. Patient-reported outcomes (PROM) were rated using surveys with questions related to aesthetics and function. The colour of the implant crown and the buccal gingiva, the appearance of the papilla, periodontal health and temporomandibular disorder (TMD) outcomes were assessed in a clinical examination. The Mann-Whitney, Chi-square and Signed Rank tests were performed.

Results
Patients with an ISC-L and ISC-C were equally satisfied with the crown shape and colour at T0 and T1. No differences in TMD outcomes were reported by the patients and no clinical signs of TMD were observed. At T1, ISC-C had more bleeding on probing and a three mm greater pocket depth than ISC-L (p = 0.03, p = 0.01, respectively). At T0, operators graded the crown colour of ISC-L as being too dark (35%) and ISC-C as being too light (40%). At T1, no difference was seen between the two groups regarding crown colour, gingiva colour and the papilla (p = 0.2749, p = 0.2099, p = 0.8053, respectively).

Conclusions
The PROM and clinical examination show that ISC-L and ISC-C are equivalent with regard to aesthetics and function in the long term.

Clinical relevance
Although ISC-L and ISC-C are aesthetically and functionally comparable in the long term, ISC-Cs are more likely to impact periodontal health.
Walking back from the edge: thresholds of change reveal options for adaptation to water scarcity under climate change in the Murray–Darling Basin, Australia
Authors: Lesslie Ellen , Colloff Matthew J. , Pittock Jamie 
Published: November 2023

AbstractClimate change has increased the variability of river inflows in the Murray–Darling Basin, threatening the viability of irrigated agriculture, food processing industries and ecological condition of wetlands. With increasing water scarcity, decision-makers and communities face heightened contestation over scarce water resources and trade-offs and adaptation have become increasingly necessary. We used a social-ecological systems approach to identify thresholds of change in the Goulburn–Broken Catchment, a major food-producing region, to reveal options for adaptation to climate change. We developed systems models whereby feedbacks are identified between sub-systems of cultural paradigms, policies, human well-being and environmental condition. Models were constructed using data from semi-structured interviews with managers and decision-makers, industry reports and the scientific literature. We found environmental thresholds are fixed, but whether they are exceeded is socially determined. Environmental condition can be maintained by relaxing constraints on volumes of water released into the highly regulated river system and easing rules on the distribution of water among users in the dairy and horticulture industries. Socio-economic thresholds were more flexible. Industries have adapted to water scarcity through irrigation efficiency measures, inter-industry relationships for water-sharing and feed substitutes in dairy production. However, industry interdependence indicates potential for maladaption, whereas investment in adaptation and diversification offers more sustainable options. Current policy and management disconnects between water for the environment and water for food production reveal opportunities for co-benefits between environmental and socio-economic domains. Realising these benefits requires a systemic, inclusive adaptation pathways approach to design and implement options for change.
Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics
Authors: Dong Yao , Han Mei , Fei Teng , Liu Huan , Gai Zhonghui 
Published: November 2023

AbstractVarious approaches have been used to study the relationship between prebiotics and probiotics. The utilization of different carbohydrates by probiotics depends on the biochemical properties of the enzymes and substrates required by the microbial strain. However, few studies have systematically analyzed the ability of probiotics to utilize different prebiotics. Here, we investigated the effects of prebiotics from different manufacturers on the proliferation of 13 strains of the Lactobacillus group and the genus Bifidobacterium co-cultured in vitro. Inulin, fructose-oligosaccharide (FOS), and galactose-oligosaccharide (GOS) had broad growth-promoting effects. FOS significantly promoted the proliferation of B. longum. When strains from Lactobacillus group and Bifidobacterium were co-cultured, FOS caused each strain to proliferate cooperatively. GOS was effectively used by L. rhamnosus and L. reuteri for energy and growth promotion. L. casei and L. paracasei fully metabolized inulin; these strains performed better than other strains from Lactobacillus group and Bifidobacterium. Media containing a mixture of oligosaccharides had stronger effects on the growth of B. animalis subsp. lactis, L. acidophilus, and L. rhamnosus than media containing single oligosaccharides. Thus, different oligosaccharides had different effects on the growth of probiotics, providing a scientific basis for the use of synbiotics in health and related fields.
Coppice reintroduction in the Czech Republic: extent, motivation and obstacles
Authors: Kozdasová Anežka , Galčanová Batista Lucie , Hédl Radim , Szabó Péter 
Published: November 2023

AbstractCoppicing is a form of forest management in European broadleaved forests. While it is still practised in south-eastern Europe, in central and western Europe it was almost completely replaced by high forest management. Currently, there are increasing efforts to reintroduce coppice management into former coppice woods. However, little comprehensive knowledge is available about the extent and management of coppice reintroduction and the processes governing it. In this paper, we present an overview of localities in the Czech Republic where coppice reintroduction was taking place in 2020. We identified 8 localities and conducted 10 semi-structured interviews with experts involved in their management in order to understand what motivated them to restart coppicing and what obstacles they have had to face. The main motivation of site managers is nature conservation, while the most important obstacles are operational issues, such as bureaucracy, complicated land ownership and legal responsibilities or lack of workforce. Other motivating factors identified in other European countries (production of a renewable energy source and potential for rural employment) have so far played a minor role in the Czech Republic. We conclude that a major challenge for future forest policies will be to utilise the economic experiences of regions with active coppicing to foster the spread of coppice woods in order to combine renewable energy production with biodiversity conservation.
The integrated curriculum and student empathy: a longitudinal multi-cohort analysis
Authors: Herber-Valdez Christiane R. , Blow Julie A. , Salazar Tammy T. , Horn Kathryn V. , Herrera Dyanne G. , Lacy Naomi L. , Beinhoff Lisa , de la Rosa J. Manuel 
Published: November 2023

AbstractResearch has demonstrated erosion of empathy in students during medical education. Particularly, U.S. studies have demonstrated empathy declines during clinical training in the third and fourth year of traditional medical programs. Yet, studies conducted outside the U.S. have not confirmed this trend. Timing and extent of patient interactions have been identified as empathy-protective factors. The need to examine empathy within different learning contexts has been noted, as has the need for longitudinal and time-series research designs to analyze trajectories. Between fall 2010 and spring 2019, we assessed empathy longitudinally among six student cohorts (N = 493) at a U.S. medical school, where patient interaction occurs early and throughout an integrated curriculum. Empathy levels of students in each cohort were assessed at five time points utilizing the Jefferson Scale of Physician Empathy-Student version. We hypothesized empathy levels will not degrade by program end, and trajectories will not show patterns of decline in Years Three and Four. Analysis of Variance (ANOVA) and Linear Mixed Model (LMM) analyses were used to analyze differences at baseline and changes in empathy trajectories. ANOVA analyses revealed statistically significant differences at baseline by class cohort (F(5, 487) = [23.28], p < 0.001). LMM analyses indicated empathy was either significantly higher or not different at the end of the program (F(19, 1676) = [13.97], p < 0.001). Empathy trajectories varied among cohorts; yet, none resulted in an overall empathy decline by the end of the program. Findings demonstrate empathy in U.S. medical students can be unchanged or higher by the end of medical education. Outcomes are consistent with reports of non-declining medical student empathy outside the U.S. and support the notion of context-specificity. Results further support recent research, suggesting decreases in empathy during training can stabilize or increase by program end. These findings have important implications for future empathy research context and design considerations, as well as program planning.