bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic lethality from the combination of a histone methyltransferase, SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma
Authors: Toyohara Yusuke , Sone Kenbun , Kumegawa Kohei , Yamamoto Yoko , Hachijo Ryuta , Tanimoto Saki , INOUE FUTABA , Kukita Asako , Taguchi Ayumi , Ikemura Masako , Miyamoto Yuichiro , Tanikawa Michihiro , Iriyama Takayuki , MORI-UCHINO Mayuyo , Hamamoto Ryuji , Ushiku Tetsuo , Oda Katsutoshi , HIROTA Yasushi , Maruyama Reo , Osuga Yutaka 
Published: February 2024

Abstract

Background:
Uterine leiomyosarcoma (uLMS) has a poor prognosis owing to its high recurrence rate and resistance to chemotherapy. Therefore, novel therapeutic targets for uLMS need to be discovered.
SUV39H2 is a histone methyltransferase that promotes the repair of double-stranded DNA breaks by recruiting phosphorylated H2AX (γH2AX). In this study, we investigated the potential therapeutic targets of SUV39H2 in uLMS and the mechanism of synthetic lethality between PARP inhibitors and SUV39H2 inhibitors, OTS186935.
Methods:
First, we analyzed the mRNA and protein expression of SUV39H2 in clinical tissues of uLMS, normal myometrium, and leiomyomas using real-time polymerase chain reaction and immunohistochemistry, respectively. Next, we conducted drug sensitivity assays for OTS186935 alone and in combination with olaparib, a poly (ADP-ribose) polymerase inhibitor, using uLMS cell lines, SK-LMS-1 and SK-UT-1. We conducted an annexin assay to investigate the mechanisms of cellular death. We performed Western blotting, immunofluorescence, and chromatin immunoprecipitation sequencing (ChIP-seq) to investigate γH2AX following OTS186935 treatment in addition to in vivo experiments using nude mice with subcutaneously implanted uLMS.
Results:
SUV39H2 expression was significantly increased in uLMS compared to that in normal myometrium and leiomyomas. OTS186935 decreased cell viability in both cell lines, and its combination with olaparib resulted in synthetic lethality in SK-UT-1 cells (combination index = 0.87). Annexin assay revealed that the combination therapy induced apoptosis. After treatment with OTS186935, γH2AX accumulation decreased. ChIP-seq also showed downregulated γH2AX following OTS186935 treatment. Notably, the combination with OTS186935 and PARP inhibitor was significantly more effective in vivo.
Conclusion:
OTS186935 inhibits double-stranded DNA break repair as evidenced by γH2AX downregulation through ChIP-seq and other assays. OTS186935 combined with olaparib induces synthetic lethality in patients with uLMS.
Periodic phase shifts of longitudinally resolved terahertz radiation along two-color filament in air
Authors: LONG Juan , WANG TIE-JUN , YIN FUKANG , LIU YAOXIANG , WEI YINGXIA , LIU CHENGPU , LENG YUXIN 
Published: February 2024

Abstract

The evolution of THz waveform generated from the two-color air filament was experimentally investigated by moving an iris along the plasma channel. By taking the differentiation of the measured THz waveforms, the longitudinally resolved THz waves along 54 mm long filament were obtained. The local THz pulse undergoes periodic phase shifts. Theoretical deduction indicates that the phase shifts are mainly caused by the dispersion in the plasma channel which plays a dominant role in the evolution of the local THz waveforms.
Assessing air pollution as a risk factor for early menopause in Korea
Authors: Kim Joyce Mary , Min Jieun , Lee Jungsil , Jeong Kyungah , Ha Eun-Hee 
Published: February 2024

Abstract
Backgrounds
Ambient air pollution has become a serious public health issue that affects fertility rates in women worldwide. Therefore, there is a need to evaluate the risk factors associated with menopause to be able to inform women of the associated health risks.
Methods
We collected data from KHANES (The Korea National Health and Nutrition Examination Survey) between 2010 and 2020, from the Korean Center for Disease Control and Prevention, Ministry of Health and Welfare, and linked it with summary pollution data from AiMS-CREATE (AI-Machine Learning and Statistics Collaborative Research Ensemble for Air Pollution, Temperature, and All Types of Environmental Exposures) from 2002 to 2020. This summary data encapsulates the monthly average air pollution predictions for 226 si-gun-gu (cities, counties, and districts) in Korea. A total of 8,616 participants who had experienced menopause (early menopause: 20–45 years, N = 679; normal menopause: 46–60 years, N = 7,937) between 2002 and 2020 were included in the analysis. We employed survey logistic regression analyses to determine the associations between ambient air pollution and menopause after adjusting for covariates.
Results
There was an association between particulate matter 2.5 (PM2.5) and early menopause (adjusted odds ratio [aOR]: 1.27, 95% confidence interval [CI]: 1.23–1.32), between particulate matter 10 (PM10) and early menopause (aOR: 1.17, 95% confidence interval [CI]: 1.15–1.20), and between nitrogen dioxide (NO2) and early menopause (aOR: 1.05, 95% confidence interval [CI]: 1.02–1.09).
Conclusion
Our results are consistent with the proposed hypothesis regarding an association between exposure to ambient air pollution and early menopause. This study provides substantial quantitative evidence that further supports the need for public health interventions to improve air quality, which is a risk in promoting early menopause.
Impurity propagation in urban area with complex surface relief
Authors: Evgrafova Anna , Sukhanovskii Andrey 
Published: February 2024

Abstract
The paper presents a new approach to study of the pollution process in systems with complex surface relief. As a case study, laboratory modeling of impurity transport in an idealized urban landscape was considered. As an experimental model, we used a three-dimensional layout of the central part of Perm city (the area of five square kilometers) at the scale of 1:4000. The model was placed in a watertight container with water, and aqueous solution of sodium chloride was used as an admixture. Estimation of the governing parameters for the urban area was done using typical values of turbulent viscosity for an urban area without mean circulation. Experimental modeling provides qualitative description of the air pollution by a mixture of carbon dioxide/air from heavy traffic. It is shown that the terrain features play a significant role in the process of the pollution spreading. The admixture tends to fill the lowest areas of the model. At the same time, the presence of buildings prevents the impurity transport. A qualitative comparison of experimental results and in-situ observations is presented.
Headache or Disturbed Smell and Taste During Acute COVID-19 as Predictors of Long COVID at One Year
Authors: Agergaard Jane 
Published: February 2024

Abstract
Purpose: Long coronavirus disease (COVID) poses a significant health concern for a substantial proportion of COVID-19 patients. Viral pathogenesis studies suggest the potential of central nervous system (CNS) affection in the acute phase of COVID-19 predicting long COVID.
This study investigates whether acute COVID-19 symptoms, particularly headache and disturbed smell and taste, predict manifestations of long COVID.
Methods: This prospective cohort study included COVID-19 patients hospitalized between March 2020, and May 2021. One year after discharge, patients responded to a symptom questionnaire. Logistic regression analysis was used to determine the odds ratio (OR) for these outcomes.
Results: Of 288 eligible patients, 111 responded to the follow-up questionnaire. At 1 year follow-up, disturbed smell and taste during acute COVID-19 did not elevate the risk of long COVID. However, patients with acute headache demonstrated a tendency towards an elevated risk of CNS-related long COVID. Notably, this risk significantly increased in patients reporting dizziness (adjusted OR=4.20; 95% confidence interval (CI) 1.19 - 14.85). Neither disturbed smell and taste nor headache during acute COVID-19 indicated a statistically significant risk of worsening in fatigue, health, or total symptom score at 1-year follow-up.
Conclusion: Headache, and not disturbed smell and taste, predicted CNS-related long COVID. Further research is warranted to clarify pathways connecting CNS-related symptoms during acute COVID-19 with long COVID, aiding the efforts of addressing the range of symptoms observed among long COVID patients and developing effective interventions.
Questionnaire survey of Healthcare Professionals on Taxane-Induced Nail Change in Japan
Authors: Yamamoto Kazumasa , Tanabe Yuko , Nonogaki Kiyomi , Watanabe Shogo , Takemura Kohji , Yamanaka Taro , Kizawa Rika , Yamaguchi Takeshi , Suyama Koichi , Hayashi Nobukazu , Miura Yuji 
Published: February 2024

Abstract

Purpose: Taxanes are widely used chemotherapeutic agents that frequently cause nail changes and have a significant impact on patients’ quality of life. Despite the prevalence of taxane-induced nail toxicity, limited data are available regarding evidence-based management strategies for the prevention or treatment of taxane-induced nail changes. Therefore, we aimed to disseminate a questionnaire survey to physicians, pharmacists, and nurses involved in oncology treatment to gain accurate insights into the prevention, treatment, and evaluation of nail changes in patients with cancer in Japan.
Methods: Questions addressed prophylactic methods, evaluation practices, and treatment approaches for various nail disorders. Questionnaires were distributed on March 1, 2022, with a response deadline of December 1, 2022.
Results: Of the 120 distributed questionnaires, 88 (73.3%) responses were deemed valid. The respondents included 69 physicians (32 oncologists, 26 breast surgeons, 6 dermatologists, 3 obstetricians/gynecologists, 1 gastroenterological surgeon, and 1 urologist), 9 pharmacists, and 10 nurses. Prophylactic measures included moisturizing (58.0%), protection (42.0%), cooling therapy (37.5%), and cleanliness (33.0%). Approximately 70% of the respondents used the Common Criteria for Adverse Events (CTCAE), while approximately 30% did not use a specific evaluation method. Opinions regarding treatment with antimicrobial or corticosteroid ointments varied; however, all severe cases were referred by dermatologists.
Conclusion: This survey revealed that the management of chemotherapy-induced nail changes varies in clinical practice in Japan. These findings emphasize the need for standardized management strategies and further research.
Investigation of the Prognostic Significance of Immunohistochemical Expression of p16 and p27 in Bladder Tumors
Authors: Ezer Mehmet , Yıldız Barış 
Published: February 2024

Abstract
Objective:The most important prognostic factors in Urothelial tumors of the bladder are pathological stage and histological grade. In this study, p16 and p27 immunohistochemical expressions were investigated and it was aimed to examine their relationship with clinicopathological parameters.
Materials and Methods: In this study, 112 patients were diagnosed with bladder urothelial tumor in the Pathology Department of Kafkas University Faculty of Medicine between 2015 and 2020, were sent as transurethral bladder tumor resection material, and had clinicopathological information, paraffin blocks and hematoxylin-eosin (H&E) stained sections in the archive. case was included. P16 and p27 immunohistochemical staining was applied to the sections obtained from paraffin blocks.
Results: The data obtained showed that the P16 IHC staining scores of the protein in the cytoplasm and nucleus did not differ statistically significantly according to the gender factor in the patients included in the study. However, it is noteworthy that the protein staining frequency distribution in female patients is high, especially in weak and medium staining, while in male patients, strong staining has the highest frequency distribution (31.0%). Although the IHC staining score frequency distributions of the P27 protein are similar, the statistical analysis showed that the distributions of this protein differ according to gender to the level of p < 0.05; This difference is similar to the nuclear distribution of P16 protein; male patients mostly had strong P27 nuclear staining (35.7%), while female patients showed strong staining at low frequencies (7.1%).
Conclusion: Many parameters are used to predict prognosis in bladder tumors. As a result, it is thought that p16, p27 immunoreactivities may be helpful in predicting the clinicopathological behavior of bladder tumors, and studies involving more cases are needed.
Design and Chracterization of Prazosin Hcl Hydrogel Drug Delivery system
Authors: P.Roopasri  , V.Anjaneyullu  , VIJAYKUMAR GAMPA 
Published: February 2024

Abstract
The purpose of the present study was to get the floating microspheres of Prazosin hydrochloride and to sustain the drug to overcome the side effects as postural hypotension.A central composite design based on the response surface method was used.The preparations were made by emulsion-solvent evaporation method.In this study, a three-factors, three levels Central composite design with drug-polymer ratio (X1), Solvent ratio (X2) and Speed (X3) as independent variables were chosen for the formulation. The microspheres were evaluated for physicochemical parameters as shape, size, buoyancy percentage and drug entrapment efficiency. SEM studies showed good topology of microspheres. The cumulative % drug release of optimized formulation after 24 hours was 99.87%. Model fitting analysis revealed the release pattern followed Korsmeyer.The results demonstrated a good relationship between the predicted and experimental values, supporting the validity of the model.FTIR and DSC studies showed that there was no interaction between drug and polymers. The optimized formulation was found to be stable when subjected to accelerated stability studies. The results obtained indicated that response surface methodology may be successfully used to analyze the effect of formulation variables and develop an optimized formulation thereby reducing the severaltrials, time and cost of formulation development.
Experimental vs. natural fulgurite: A comparison and implications for the formation process
Authors: Çalişkanoğlu A. Zeynep , Cimarelli Corrado , Dingwell Donald B. , Camara Alessandra S.B. 
Published: February 2024

Abstract
Fulgurites are glassy structures formed when lightning strikes the ground, causing ground material (e.g., rocks, sediments, or soil) to melt and fuse. While fulgurites are relatively rare, they provide valuable insights into paleoecology and may play a key role in prebiotic chemistry. Despite their significance in nature, understanding the conditions underlying the formation of fulgurites poses severe challenges, as the physical parameters and timing of the fulgurite-generating lightning event still need to be discovered.
Here, we use a unique opportunity from the recent in situ discovery of a natural fulgurite still embedded in its protolith. (The natural fulgurite-generating event is visible in the World Wide Lightning Network data.) Using a high-voltage setup, we further compare this natural fulgurite with the experimentally generated fulgurite obtained from the original protolith. The natural and experimental fulgurites exhibit evidence of similar melting sequences and post-melting recrystallization structures. Using Raman spectroscopy applied to the quartz phase transition, we estimate the thermal gradient present in the fulgurite during formation to be a minimum of 1600 °C at the inner wall of the fulgurite and ca. 600 °C at the outer wall of the fulgurite. Those findings suggest that the current responsible for the cloud-to-ground lightning discharges that generated the natural fulgurite lay in the range of 11 960 to 14 473 kA. The state of the experimental fulgurites matched that of the natural fulgurite, validating the experimental option for studying fulgurite generation.
Wenlanzhangite–(Y) from the Yushui deposit, South China: A potential proxy for tracing the redox state of ore formation
Authors: Liu Peng , Li Guowu , Sun Ningyue , Yao Wei , Yu Hong , Tian Yongfei , Yang Wenqiang , Zhao Fengshang , Cook Nigel J. 
Published: February 2024

Abstract
Mineral phases in which vanadium (V) and heavy-rare-earth elements (HREEs) coexist are rarely documented. Here, we report a new V-HREE-bearing silicate mineral species, wenlanzhangite-(Y), which is a vanadiferous derivate of jingwenite-(Y) [Y2Al2V24+(SiO4)2O4(OH)4] coexisting with jingwenite-(Y) in bedded/massive ores at Yushui, South China. Wenlanzhangite-(Y) forms as a dark brown, 70–100 μm thick rim on a core domain of jingwenite-(Y), which occurs as 100–200 μm columnar crystals. The color, streak, luster, and hardness (Mohs) are dark brown, yellow-gray, vitreous, and ~4, respectively. Compared to jingwenite-(Y), wenlanzhangite-(Y) has higher vanadium and lower aluminum contents. Calculated on the basis of 8 cations, the empirical formula is (Y1.26Dy0.17Er0.11 Gd0.09Yb0.09Nd0.09Sm0.06Sc0.04Ho0.03Ce0.02Tb0.02Tm0.02Pr0.01)Σ2.00(V1.463+Al0.54)Σ2.00V24+(SiO4)2O4(OH)4, which can be simplified to the ideal formula Y2V23+V24+(SiO4)2O4(OH)4.
Wenlanzhangite-(Y) is triclinic, with space group P1(#2), Z = 2, and unit-cell parameters a = 5.9632(7) Å, b = 9.599(1) Å, c = 9.9170(9) Å, α = 90.033(8)°, β = 98.595(2)°, γ = 90.003(9)°, and V = 561.28(10) Å3. Wenlanzhangite-(Y) is approved by the International Mineralogical Association Commission on New Minerals, Nomenclature and Classification (IMA2022-142). The structure of wenlanzhangite-(Y) is composed of a-axis-oriented chains of [VO6] octahedra consisting of edge-sharing octahedra linked by insular [SiO4] tetrahedra, leaving open channels occupied by rare earth elements. Observed compositional variation and crystal structure demonstrate that V3+ can substitute for Al3+ in jingwenite-(Y), forming wenlanzhangite-(Y). The occurrence of wenlanzhangite-(Y) indicates a relatively more reducing hydrothermal environment, causing a reduction of V5+ in oxidized fluids to V3+ and thus represents a useful proxy for tracing the redox state of ore formation.
An Examination of Socio-Religious Practices of Sufi Adherents in Bida, Niger State
Authors: Yahaya Abdulrahman 
Published: February 2024

Sufis were known to have contributed to spreading Islam across the world. This paper seeks to encapsulate the early religious belief of the Nupe people in Bida, Niger state, until the introduction of Islam by the Sufis. The emergence of Sufism was assessed rightly from the time of Qadiriyyah Sufi practice and some scholars that were known with it, like Sheikh Abdulrahman Muhammad bin Sharif and Sheikh Muhammad Wazir (1882-1945), called “Waziri Mamma” before the emergence of Tijjaniyyah Sufi order through a scholar Man-Haruna, alias “Man-yisa Naku” in Banwuya, during the reign of the 2nd Etsu Nupe Muhammadu Saba (1859-1873) known as “Ma’asaba”. The paper adopted a qualitative survey where Interviews were conducted with seasoned Sufi members. The researchers purposively selected participants for the study because they are Muslims and possess knowledge about the phenomenon investigated. The paper provides an overview of some socio-religious practices of Sufis in Bida, Niger State, with the way and manner they are practised in accordance with the teachings of Islam and also reveals the effects of training on adherents by the Sufis in Bida.Contribution: This study contributes to revealing the shift of the Nupe people from polytheism to Monotheism with the role of the Sufis.
Modernism and Crisis: Seyyed Hossein Nasr's Idea on Spiritual Intelligence and Its Relevance Today
Authors: Handoko Suryawan Bagus , Suteja Suteja , Hania Irfan , Kafrawi Shalahudin 
Published: February 2024

Modern humans are experiencing various acute crises. Scientific and technological advancements have ironically become a boomerang for humanity, dominating nature and creating a materialistic and hedonistic lifestyle. This study aims to discover Seyyed Hossein Nasr's perspective on spiritual intelligence and the importance of social virtue education in dealing with modern human problems. This qualitative study employs productive interpretation to analyse the data extracted from the main works of Seyyed Hossein Nasr. This study revealed that Nasr's insights shape a fundamental understanding that promotes spiritual awareness within the educational context, encouraging the integration of spiritual values into the social domain. Such integration will create a more just, empathetic, and environmentally conscious society. Nasr's ideas also provide a pathway to address the challenges posed by modernity by returning to spiritual values and adopting a balanced approach to religion and culture.Contribution: The contribution/urgency that the article gives through this exploration is to shed light on the intricate interplay between spirituality, education, and social values, enriching Nasr's timeless contributions.
Developing a management and operation model for water and wastewater components using the equilibrium optimization algorithm
Authors: Kilic Selami , Ates Abdullah , Firat Mahmut , Yilmaz Salih 
Published: February 2024

AbstractA novel optimization model was developed using the equilibrium optimization algorithm to define the most appropriate management process according to the current state of urban water components in utilities. The basis of the optimization model is the current status analysis and management system, which consists of 11 main headings and 231 components. This model is applied for three utilities, and the results are presented in comparison with real-time data. Currently, the number of components with 0 or 1 score is 28, 19 and 69, respectively. The current average scores of the components in the utilities were obtained as 2.84, 3.43 and 2.48, respectively. Then, the improvement process of these components is optimized by the equilibrium optimization algorithm. The most appropriate targets were defined as 3.90, 4.15 and 3.71, respectively, with the optimization algorithm by considering the current scores in the utilities. The target scores for water supply, wastewater collection and treatment components are determined as 3.81, 4.05 and 3.84 for utility I; 4.03, 4.18 and 4.22 for utility II; and 3.51, 3.56 and 4.05 for utility III. The proposed model will be a reference for defining the most appropriate target and determining the management process.
The Complicated Pop-cultural Legacy of Figura Christi. Mythologization of the Christ Narrative in the Context of Current Christian Philosophy
Authors: Jemioł Maciej 
Published: February 2024

Reflecting on the many challenges facing Christianity as a religion, and particularly Christian philosophy as a way of thinking in modern, strange and unfamiliar times, one encounters time and again the grim realization that many of such challenges are simplyprovided by the current culture, the cultural sphere. Without idealizing Europe’s Christocentric culture and remembering that it was not homogeneous, we must recognize that it once existed, it was the ruling cultural norm. Today, such norms are indeed very different and vary greatly depending on the geographic region we have in mind and change from decade to decade. After the Renaissance, the Enlightenment, modernity and the postmodern era, we observe that what governs our cultural world today is pluralism more than anything else. But there are still some traces of Christocentrism in our culture and in what it has become during this period, namely popular culture. Among other aspects, research has focused on the analysis of one idea – that of the Christ-figure, which has come a long way from theology to culture to pop culture over the centuries. In this article, I will try to show why this complicated legacy can be seen, at least in part, as a challenge to Christianity in light of contemporary Christian philosophy.
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Received: 14/03/2023. Reviewed: 16/04/2023. Accepted: 30/04/2023.