bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience profiles and related factors among colorectal cancer inpatients with an enterostomy: A cross- sectional study
Authors: Sun Dandan , Zhang Yan , Ma Hui , Wu Jinqiu 
Published: November 2023

Abstract
Purpose
This study aimed to explore psychological resilience subgroups of colorectal cancer inpatients with an enterostomy through latent profile analyses and to identify the sociodemographic, clinical and psychological characteristics among resilience subgroup members.
Methods
A cross-sectional study was conducted. 226 colorectal cancer patients after enterostomy were recruited in the study. Data were collected with a general information questionnaire, Conner Davidson Resilience Scale, Medical Coping Modes Questionnaire, Stoma Self-Efficacy Scaleand Social Support Rating Scale.
Results
Three distinct subgroups of resilience were identified: “adaptation difficulty group” (33.6%), “moderate adaptation group” (29.2%) and “complete adaptation group” (37.2%). Monthly per capita family income, social support, and self-efficacy were predictors of resilience subgroups.
Conclusion
The resilience of colorectal cancer patients after enterostomy can be divided into several subgroups. The decrease in family income per month, self-efficacy and social support will increase the risk of patients belonging to the adaptation difficulty group or moderate adaptation group. Clinical nurses should develop targeted intervention programmes based on the characteristics of subgroups at high risk of resilience to further improve patient resilience.
Bladder cancer risk stratification with the Oncuria 10-plex bead-based urinalysis assay using three different Luminex xMAP instrumentation platforms
Authors: Furuya Hideki , Sakatani Toru , Tanaka Sunao , Murakami Kaoru , Waldron Richard T , Hogrefe Wayne , Rosser Charles J 
Published: November 2023

Abstract
Background: No single marker of bladder cancer (BC) exists in urine samples with sufficient accuracy for disease diagnosis and treatment monitoring. The multiplex Oncuria BC assay noninvasively quantifies the concentration of 10 protein analytes in voided urine samples to quickly generate a unique molecular profile with proven BC diagnostic and treatment-tracking utility. Test adoption by diagnostic and research laboratories mandates reliably reproducible assay performance across a variety of instrumentation platforms used in different laboratories.
Methods: We compared the performance of the clinically validated Oncuria BC multiplex immunoassay when data output was generated on three different analyzer systems. Voided urine samples from 36 subjects (18 with BC and 18 Controls) were reacted with Oncuria test reagents in three 96‑well microtiter plates on Day 1, and consecutively evaluated on the LED/image‑based MagPix, and laser/flow based Luminex 200 and FlexMap 3D (all xMAP instruments from Luminex Corp., Austin, TX) on Day 2. The BC assay uses magnetic bead‑based fluorescence technology (xMAP, Multi-analyte profiling; Luminex) to simultaneously quantify 10 protein analytes in urine specimens [i.e., angiogenin (ANG), apolipoprotein E (ApoE), carbonic anhydrase IX (CA9), CXCL8/interleukin-8 (IL-8), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-10 (MMP-10), serpin A1/alpha-1 anti-trypsin (A1AT), serpin E1/plasminogen activator inhibitor-1 (PAI-1), CD138/syndecan-1 (SDC1), and vascular endothelial growth factor-A (VEGF-A)].
Results: All three platforms categorized all 10 analytes in identical samples at nearly identical concentrations, with variance across systems typically <5%. While the most contemporary instrument, the FlexMap 3D, output higher raw fluorescence values than the two comparator systems, standard curve slopes and analyte concentrations determined in urine samples were concordant across all three units. Forty-four percent of BC samples registered ≥1 analyte above the highest standard concentration, i.e., A1AT (n=7/18), IL-8 (n=5), and/or ANG (n=2). In Controls, A1AT was higher in one sample.
Conclusion: Multiplex BC assays generate detailed molecular signatures useful for identifying BC, predicting treatment responsiveness, and tracking disease progression and recurrence. The similar performance of the Oncuria assay across three different analyzer systems supports test adaptation by clinical and research laboratories using existing xMAP platforms.
Trial Registration:This study was registered at ClinicalTrials.gov as NCT04564781, NCT03193528, NCT03193541, and NCT03193515.
The Effect of Dialysis Modality on Annual Mortality: a Prospective Cohort Study
Authors: Kim Yae Hyun , Kim Yeonjin , Ha Nayoung , Cho Jang-Hee , Kim Yon Su , Kang Shin-Wook , Kim Nam-Ho , Yang Chul Woo , Kim Yong-Lim , Lee Jung Pyo , Lee Woojoo , Oh Hyung Jung 
Published: November 2023

Abstract

Despite several studies on the effect of each dialysis modality on mortality, the subject is still controversial. We investigated the hazard rate of mortality for patients with incident end-stage renal disease with respect to initial dialysis modality (hemodialysis vs. peritoneal dialysis). We used a nationwide, multicenter, prospective cohort of patients with end-stage renal disease who were undergoing dialysis in South Korea. Among the 2 207 patients, 1 647 (74.6%) underwent hemodialysis. We performed the intention-to-treatment analysis, and employed inverse probability treatment weighting to reduce bias and the weighted Fine and Gray model over the follow-up period. Landmark analysis was used to identify the changing effect of the dialysis modality on individuals who remained event-free at each landmark point. No significant difference in hazard rate was observed between the two dialysis modalities when all participants were considered. However, the hazard rate in the peritoneal dialysis group was significantly higher than that in the hemodialysis group among patients aged <65 years after 4- and 5-year follow-up. A similar pattern was observed among patients with diabetes mellitus. Landmark analysis showed that the hazard ratio in the peritoneal dialysis group was significantly higher than that in the hemodialysis group at 2 years in both the education-others and married groups. This study could be useful for choosing a dialysis modality for young patients, especially in the presence of diabetes. Moreover, hemodialysis may be preferred to peritoneal dialysis when the follow-up duration is >3 years.
360-Degree Virtual Reality Video to Teach Neonatal Resuscitation: An Exploratory Development Study.
Authors: Tachejian Sevag , Moussa Ahmed 
Published: November 2023

Abstract

Simulation is an effective training method for neonatal resuscitation (NR). However, the limitations brought about by the COVID-19 pandemic, and other resource constraints, have necessitated exploring alternatives. Virtual reality (VR), particularly 360-degree VR videos, have gained traction in medical training due to their immersive qualities. The primary objectives of the study were to produce a high quality 360-degree virtual reality (VR) video capturing neonatal resuscitation (NR) and to determine if it could be an acceptable adjunct to teach NR. The secondary objective was to determine which aspects of NR could benefit from the incorporation of such a video in training. This was an exploratory development study. The first part consisted of producing the video using a GoPro action camera, Adobe Premiere Pro, and Unity Editor. In the second part participants were recruited, based on level of experience, to watch the video and answer questionnaires to determine acceptability (user experience and cognitive load) and aspects of NR which could benefit from the video. The video was successfully developed. Forty-six participants showed a strong general appreciation. User experience revealed high means (> 6) in the positive subscales and low means (< 4) for immersion side effect, with no difference between groups. Cognitive load was higher than anticipated. Participants indicated that this video could be effective for teaching crisis resource management principles, human and environment interactions, and procedural skills. The 360-degree VR video could be a potential new simulation adjunct for NR. Future studies are needed to evaluate learning outcomes of such videos.
A novel classification for guiding the surgical approach for cranio-orbital lesions: A single institution case series of 45 cases and a literature review.
Authors: Xie Bo , Qin Chaoying , Zhang Sen , Zhang Chi , He Yi , Tang Guodong , Wang Xiangyu , Liu Qing 
Published: November 2023

Abstract
Objectives
We aim to share our experience of the removal of COLs, and propose a novel classification to guide the approach selection.
Methods
We retrospectively reviewed 45 consecutive patients with COLs who underwent surgery performed by the same neurosurgeon between November 2010 and November 2022. The surgical approach was selected according to the anatomical region classification of the COLs. For lesions limited to space A (lateral superior orbital fissure, SOF), the pterion or extended pterion approach (PA or EPA) was used. For lesions limited to space B (extraconal compartment medial SOF, and cavernous sinus CS) and C (intraconal compartment, medial SOF, and CS), the pretemporal transcavernous approach (PTCA) was used. For lesions limited to space D (intraconal compartment and optic canals), the subfrontal approach (SA) was used. For lesions extending into the infratemporal fossa (ITF), the cranio-orbito-zygomatic approach (COZA) was used. For lesions involving pterygopalatine fossa (PPF), the endoscopic transnasal approach (ETNA) was used. We analyzed the clinical manifestations, imaging data, surgical approaches, surgical outcomes, neurological outcomes, and follow-up data.
Results
Gross total resection was performed in 35 patients (35/45, 77.8%). SA, PA, EPA, PTCA, COZA, and ETNA were performed in 9, 9, 10, 10, 6, and 1 case(s), respectively. Progression of the residual tumor was observed in 6 cases (1 adenoid cystic carcinoma and 5 meningiomas).
Conclusion
Surgical approach selection plays a vital role in patient prognosis. This novel classification based on the involvement of anatomic space could help surgeons select an appropriate approach to remove the COLs.
Novel physiological paradigm for assessing reward anticipation and extinction using cortical direct current potential responses in rats
Authors: Matsuda Yoshiki , Ozawa Nobuyuki , Shinozaki Takiko , Tatebayashi Yoshitaka , Honda Makoto , Shinba Toshikazu 
Published: November 2023

Abstract

Anhedonia is characterized by reduced motivation, decreased sensitivity to rewards, and diminished pleasure. However, no direct neurophysiological method is available to assess motivational anhedonia with disrupted reward anticipation. We established a novel physiological paradigm using cortical direct current (DC) potential responses in rats to assess reward anticipation. This paradigm consisted of five daily 1-h sessions with two tones, where the rewarded tone was followed by electrical stimulation of the medial forebrain bundle every second, while the unrewarded tone was not. On day 1, both tones led to a negative DC shift immediately after auditory responses. This negative shift progressively increased and peaked on day 4, with the rewarded tone exhibiting a significantly larger magnitude. The DC shift from 600 to 1000 ms significantly increased following the rewarded tone compared with that following the unrewarded tone on day 3. This DC shift was prominent in the frontal cortex and played a crucial role in discriminative anticipation. During the extinction sessions, the shift diminished significantly on day 1. These findings suggest that cortical DC potential is related to reward anticipation and could be a valuable tool for evaluating animal models of depression, providing a testing system for anhedonia.
Spatial Heterogeneity study of Early Child Marriages before and after implementation of Prohibition of Child Marriage Act (2006) in India: Evidence from National Family Health Survey, 2015-16
Authors: Mayank Mayank Singh , ANUJ ANUJ SINGH , Jagriti Jagriti Gupta 
Published: November 2023

Abstract

Background
Despite numerous laws, rights, and well-known health concerns, child marriage remains to be prevalent in developing countries such as India. This practice is fueled by a complex interaction of social and normative attitudes and values that are understated in national and even state-level assessments of child marriage drivers. This study aims to assess the spatial pattern and associated factors of early-marriage before and after Prohibition of Child Marriage Act in Indian districts among reproductive aged women.
Methods
Univariate and Bivariate analysis, Multiple logistic regression, Moran’s I Statistics and Regression analysis (OLS and Spatial Error/Lag Model) were carried out for the analysis of data in our study. The data came from the fourth round of the National Family Health Survey (2015-16).
Results
This study finds wide inter districts heterogeneity in levels of child marriage, one decade before and after prohibition of child marriage across India. The prevalence of child marriage has substantially declined (nearly 21%) after implementation of prohibition of child marriage act. Bivariate Moran’s I value for rural was found to be highest 0.76 and 0.72 before and after implemented act respectively suggesting high spatial auto-correlation of early-marriages in the rural-districts of India.
Conclusions
The findings of this study show that the prevalence of child marriage has substantially declined after implementation of child marriage act but this declining trend of child marriage has been accompanied by many factors apart from enforcement of laws against child marriage practice. Furthermore, future child marriage programs and policies should take into account improving economic status, enhancing female sovereignty and marital decision-making in the home, as well as the geographic, social, and normative aspects of the local community.
Study on the mechanism of action of Wu Mei Pill in inhibiting rheumatoid arthritis through TLR4-NF-κB pathway
Authors: Fu Yuheng , Gao Chunyu , Teng Hongbo , Sun Xialin , Zhao Yaru , Zhang Wenxin , Li Siwen , Huang Liang , Fan Bowen , Zhao Yan , Zhang Haibo 
Published: November 2023

Abstract
Background
Wu Mei Pills (WMP) is a traditional Chinese medication that exhibits considerable anti-inflammatory effects. While WMP has been documented for its efficacy in treating RA, its mechanism of action on the condition remains unestablished.
Methods
The chemical composition of WMP was analysed through UPLC-MS. Next, the ELISA, cell scratch, Transwell, and Western blotting techniques were used to investigate its intrinsic mechanism. Lastly, the effect of WMP in inhibiting RA was explored by applying it to CIA rats.
Result
UPLC-MS analysis detected 181 compounds in WMP. RA-FLS migration and invasion mechanisms were significantly hindered by serum containing WMP (2%, 8%). Moreover, WMP (0.5 g/kg, 2 kg/kg) restricted arthritis and immune organ indices in CIA rats with type II collagen-induced rheumatoid arthritis by blocking TLR4-NF-κB inflammatory pathway activation.
Conclusions
WMP is valuable in mitigating the course of RA through inhibiting the classical TLR4-NF-κB inflammatory pathway and reducing the secretion of inflammatory factors in the serum of RA-FLS and CIA rats. Moreover, it regulates the dynamic balance of MMP-2/TIMP-2, MMP-9/TIMP-1, modulates the mechanism of RA-FLS invasion, and safeguards articular cartilage tissues in RA.
Implants equipped with blades aiming to control the lateral pressure on the cortical bone. An experimental study in dogs
Authors: Kanayama Masatsugu , Ferri Mauro , Guzon Fernando M. Muñoz , Asano Akihisa , Alccayhuaman Karol Alí Apaza , De Rossi Ermenegildo Federico , Botticelli Daniele 
Published: November 2023

Abstract
Background
To avoid cortical compression, several implant systems have included dedicated drills aimed at widening the cortical region of osteotomy. However, the manual execution of this operation does not guarantee the necessary precision. Hence, the present study aimed to determine the optimal size of the recipient site at the level of the alveolar crest in relation to the size of the coronal region of the implant to achieve the best healing result. Materials and methods: Blades of different diameters were incorporated into the coronal part of the implant to prepare the cortical region of the bone crest in different dimensions in relation to the collar of the implant. The differences in diameter of the blades in relation to the collar of the implant were as follows: one control group, -175 µm, and three test groups, 0 µm, + 50 µm, or + 200 µm. Results: The marginal bone loss (MBL) at the buccal aspect was 0.7 mm, 0.5 mm, 0.2 mm, and 0.7 mm in the − 175 µm, 0.0 µm, + 50 µm, + 200 µm groups, respectively. The differences were statistically significant between group + 50 µm and control group − 175 µm (p = 0.019), and between + 50 µm and + 200 µm (p < 0.01) groups. The level of osseointegration at the buccal aspect was more coronally located in the test groups than in the control group, whereas the bone-to-implant contact percentage was higher in the + 50 µm and + 200 µm groups. However, these differences were not statistically significant. Conclusions: The lowest bone crest resorption and highest levels of osseointegration were observed in the 0.0 µm and + 50 µm groups. Only the difference between the + 50 µm and control + 200 µm groups was significant. The cortical region where the blades had performed their cutting action showed regular healing with perfect sealing in all the groups. Cortical blades gathered bone particles, particularly in the + 200 µm group, which were incorporated into the newly formed bone. The results from the present experiment provide support to the use of blades that produce a marginal gap of 50 µm after implant insertion.
A Review of Additive Usage in Polymer Manufacturing: Case Study Phenolic Antioxidants
Authors: Orndoff Derek , Lone Sohail , Beymer-Farris Betsy , Wood Morgan , Sadler Jennifer , Ternes Mary Ellen , Hester Tracy , Miller Kevin M. , Seay Jeffrey 
Published: November 2023

Abstract
The March 2, 2022, United Nations Resolution 5/14: “End plastic pollution: Towards a legally binding instrument” by 2024 provides an important path forward for addressing global plastic pollution, beginning with monomer design and production through the value chain to the final fate of plastic products, including resource recovery. Of the many goals set for this effort, simplifying the polymer and additive universe is one of the most significant. One of the primary obstacles to resource recovery from plastic waste is the variability of the plastic universe, which renders post-use plastic inherently waste-like and virtually unrecoverable. The toxicity levels of chemical additives in plastics are a significant threat to human and ecosystem health. Another obstacle is leakage of microplastic generated during the recovery and recycling process and is now traceable in our ecosystems, our food, and even our bodies. Thus, while simplification measures will not address microplastic and leaching of chemicals during use of plastic, such as for tires, synthetic fibers and coatings, these measures simplify the plastic universe and mitigate microplastic leakage that is fundamentally critical to ensuring a circular use of plastic in our society. This study provides a proof of concept for simplification of the plastic universe through elimination of additives revealed as problematic due to unnecessary redundancy and variability, as well as persistence, bioaccumulation, and toxicity. Further, this study provides a specific focus on to revealing potential paths toward both simplifying and reducing the variability in polymers, plastic waste streams and ultimately plastic pollution, while preserving critical uses and supporting circularity. This study focuses on phenolic antioxidants to prove this concept, however, the same principles discussed and illustrated herein can be applied to other additive classes.
Associational effects of Desmodium intercropping on maize resistance and secondary metabolism
Authors: Bass Ethan , Mutyambai Daniel , Midega Charles , Khan Zeyaur R , Kessler André 
Published: November 2023

Abstract
Intercropping is drawing increasing attention as a strategy to increase crop yields and manage pest pressure; however the mechanisms of associational resistance remain controversial. We conducted a controlled experiment to assess the impact of co-planting with silverleaf Desmodium (Desmodium uncinatum) on maize secondary metabolism and resistance to herbivory by the spotted stemborer (Chilo partellus). Two maize varieties were grown either with Desmodium or adjacent to it in separate pots. Our findings indicate that co-planting with Desmodium influences secondary metabolism and herbivore resistance through both above and below-ground mechanisms. Stronger effects were generally observed when maize and Desmodium shared the same pot, implying that direct root contact or soil-borne cues play an important role in mediating associational effects on plant resistance in this system.
Accuracy of the recording of pneumonia events in English electronic healthcare record data in patients with chronic obstructive pulmonary disease
Authors: Adamson Alexander J , Kallis Constantinos , Douglas Ian , Quint Jennifer K. 
Published: November 2023

Abstract

BACKGROUND
In primary care, identifying pneumonia events in people with chronic obstructive pulmonary disease (COPD) may be challenging due to similarities in symptoms with COPD exacerbations and lack of diagnostic testing. This study explored the accuracy of pneumonia diagnosis coded in primary care by comparing diagnosis in primary care with diagnosis in hospital.
METHODS
A study population of people with COPD in England was created using the Clinical Practice Research Datalink Aurum database linked with Hospital Episode Statistics inpatient data. Pneumonia codes only, and pneumonia code with associated clinical and/or treatment codes (chest x-ray, symptoms, antibiotics, sputum and blood culture) were used to determine pneumonia events in primary care. Events that were followed by hospitalisation within 7 days were used to estimate the positive predictive value (PPV) of pneumonia coding in primary care, using primary diagnosis of pneumonia in secondary care as the gold standard. The PPV of primary care recording of hospitalised pneumonia was also calculated.
RESULTS
274,156 COPD patients were eligible for inclusion, of whom 7,560 had an eligible pneumonia event in primary care diagnosed between 2015–2019 which was not ‘hospital-acquired’ and was diagnosed and entered on the same day. Of the 2,094 events which were followed by hospitalisation within 7 days, 1,208 had a primary diagnosis of pneumonia in hospital, representing a PPV of pneumonia coding in primary care of 57.7% (95% CI 55.6%-59.8%). Another 284 (13.6%) were diagnosed as a COPD exacerbation and 114 (5.4%) were diagnosed as another respiratory disease. Use of additional pneumonia clinical and treatment codes had a modest effect on the PPV but substantially lowered the number of events. Of the 33,603 eligible pneumonia events identified in secondary care, only 11,445 were recorded in primary care within 42 days, representing a sensitivity of 34.1% (95% CI 33.6%-34.6%).
CONCLUSIONS
Use of primary care pneumonia codes and associated clinical and treatment codes to determine pneumonia is not recommended due to significant levels of misdiagnosis and many hospitalised events failing to be recorded in primary care.