bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic analysis of the modern inhibitors of the renin‑angiotensin system in patients with arterial hypertension in the Russian Federation
Authors: Nedogoda S. V. , Salasyuk A. S. , Barykina I. N. , Lutova V. O. , Popova E. A. 
Published: November 2023

Objective. To evaluate the cost-effectiveness of the use of modern inhibitors of the renin-angiotensinaldosterone system (RAAS) in patients with arterial hypertension (HTN) in the Russian Federation.Design and methods. An analytical decision-making model was built in MS Excel, which enables to evaluate the additional benefit in reducing blood pressure and preventing cardiovascular outcomes when prescribing the most effective RAAS inhibitors in patients with HTN over 65 years of age on the background of antihypertensive therapy (AHT) (as a basic RAAS blocker the following agents were considered: valsartan 80 mg, enalapril 20–40 mg, lisinopril 10–20 mg, perindopril 2,5–5 mg, candesartan 8–32 mg, irbesartan 150 mg, losartan 50–100 mg, olmesartan 10 mg and telmisartan 40 mg).Results. Azilsartan medoxomil 80 mg is the most effective and will prevent 3,86 cases of myocardial infarction, 2,48 cases of acute cerebrovascular accident and 1,66 deaths from all causes per 1000 patient-years. At the same time, reducing the cost of managing complications and saving lives makes therapy with modern RAAS inhibitors economically feasible, reducing the total costs of illness. Taking into account the direct costs of treating adverse events, as well as the indirect costs of disability benefits and gross domestic product losses, the maximum potential savings can be achieved when using irbesartan 300 mg — 10,384,47 rubles/year of therapy, azilsartan 20 mg — 9 035,90 rubles/year of therapy, azilsartan 40 mg — 8 500,82 rubles/year of therapy, azilsartan 80 mg — 8 384,14 rubles/year of therapy, telmisartan 80 mg — 8 721,41 rubles/year of therapy and candesartan 32 mg — 8 204,21 rubles/year of therapy.Conclusions. The use of modern RAAS inhibitors, including azilsartan medoxomil in hypertensive patients, leads to a reduction in healthcare costs, the achievement of the targets of the national project “Fight against cardiovascular diseases”, while significantly improving the prognosis of patients and their quality of life.
Investigating the relationship between changes in blood glucose, glycosylated hemoglobin (HbA1c), lipids and changes in hepatic enzymes in patients
Authors: talebi mahboobeh , rahanjam adel 
Published: November 2023

Abstract
BACKGROUND & AIMS: The main risk factors for non-alcoholic fatty liver disease are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes’ activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, in this study investigated the relationship between changes FBS, cholesterol, HbA1c, and triglyceride and changes in hepatic enzymes in patients Fajr Hospital in Tehran.
Methods
Samples with SGPT levels > 40 U/L were selected and blood samples from the same individuals were collected in testing six months later. The changes in four factors of FBS, HbA1c, cholesterol, and triglyceride were calculated in these two consecutive visits, and finally, they were compared with changes in the hepatic enzymes and the relationship between them was evaluated by SPSS.
Results
Fifty-seven individuals with a mean age of 48 ± 15 years and SGPT > 40 U/L were included in the present study. Six samples were female (10.52 %) and 51 samples were male (89.48 %). The results showed that there was no significant relationship between FBS and HbA1c changes and hepatic enzymes. However, there was a significant relationship between cholesterol and triglyceride changes and hepatic enzymes of SGPT and SGOT (p ˂ 0.05).
Conclusions
Results of study show, changes in FBS and HbA1c in two consecutive visits cannot be used to follow up on the treatment of fatty liver .However, changes in cholesterol and triglyceride can be used for monitoring the treatment in people with abnormal levels of hepatic enzymes.
Aminocoumarin-based heme oxygenase activity fluorescence probe reveals novel aspects of HO-1 regulation
Authors: Boyle Joseph , Chiappo Derick , Cooper Saul , Sinha Shivani , Tapeng Lunnathaya , Walter Edward , Lai Titan , Long Nicholas J. 
Published: November 2023

Abstract
Heme oxygenase-1 (HO-1) is crucial for vascular health and heme homeostasis. Whilst protective, HO-1 is increased in numerous cardiovascular diseases, including atherosclerosis. We previously reported a prototype fluorescent probe for HO-1 enzyme activity. Here, we describe the synthesis and biological characterisation of an improved novel red-shifted HO-1 fluorescent probe, AMC-Hem. Its use yielded novel insights into HO-1 regulation in human monocyte-derived macrophages (hMDMs). AMC-Hem measured and imaged real-time HO-1 activity in live cells for the first time. HO-1 activity was concentrated at the outer edge of lysosomes containing phagocytosed erythrocytes. AMC-Hem identified two novel small molecules that regulate HO-1 enzyme activity, by non-transcriptional mechanisms, a new insight into HO-1-regulation. AMC-Hem measured HO-1 enzyme activity in serum from healthy individuals. Therefore, this study demonstrates real-time measurement and visualisation of HO-1 activity with AMC-Hem for the first time and promises to facilitate new insights into its function and clinical relevance.
Obtaining Technical Silicon From the Sand of the Quartz Deposit “Jerdanak”
Authors: Jiyanova Sayyora , Turayev Khayit , Eshmurodov Khurshid 
Published: November 2023

Abstract
In this article, the chemical and mineralogical composition of the local quartz sands of Surkhandarya region was initially determined by the method of X-ray phase analysis. The sand was then washed and dried several times in distilled water for enrichment. The resulting clean sand was crushed, sifted and returned with magnesium at temperatures of 600–1800°C at intervals of 2–10 hours, technical Silicon (93%-94%) was obtained. Silicon oxide and magnesium metal for magniothermal extraction 2:1, 1:1, 1:2, 1:3, 1:4, 1:7 the goods were taken in proportions. It was washed three to four times in distilled water, hydrochloric acid, alkali to extract Silicon from the composition of the resulting reaction mixtures. The purity of the extracted Silicon was studied using X-ray phase and element Analysis. The study found that the optimum temperature for reaction of silicon oxide with magnesium was 800°C temperature, reaction duration was 6 hours, with a molar ratio of silicon oxide and magnesium of 1:2, the reaction yield showed the highest result of 98,8%.
Identification and expression analysis of the FtsH protein family in chickpea in response to drought stress
Authors: Dey Sharmistha , Malviya Rinku , Pandey Anuradha , Banavath Hemanth Naick , Muthamilarasan Mehanathan , Gayen Dipak 
Published: November 2023

Abstract
Harsh environments continuously impact the growth and development of plants, leading to reduced productivity. Therefore, it is crucial to study the acclimation processes to understand the underlying mechanisms for developing climate-resilient plants. Chickpea (Cicer arietinum L.) is a leguminous crop known for its high protein and carbohydrate content. Though the crop is grown in arid and semi-arid regions, they are vulnerable to extreme stress conditions such as drought stress. Studies on drought-responsive genes were therefore necessary on important economical crop plant like chickpea. The filamentous temperature-sensitive protease H (ftsH) family is speculated to play roles in drought stress response. FtsH protease is a membrane-anchored, zinc metalloprotease, belonging to AAA protease family restricted to organelles of endo-symbiotic origin. FtsH is a critical gene for plant chloroplast development and its photosynthetic control. In our present study, we have identified fourteen FtsH protease-encoding genes providing a comprehensive analysis of the Ca-FtsH gene family. The structure and organization of FtsH genes and their corresponding proteins were studied using different in-silico tools and expression profiling was performed through qRT-PCR. The CaFtsH genes play a crucial role in plant growth and development under abiotic stress, revealed by their differential expression pattern during different stress conditions. The gene expression provided a basis for the functional analysis for the stress-responsive ABA signal transduction pathways. These findings contribute to a better understanding of the biological significance of the FtsH genes and requires further characterization to dissect the precise role of these genes.
Comparison of young femoral neck fractures treated by femoral neck system, multiple cancellous screws and dynamic hip screws: a retrospectively comparison study
Authors: Cai Leyi , Zheng Wenhao , Chen Chunhui , Hu Wei , Chen Hua , Wang Te 
Published: November 2023

Abstract

Background Implant choice for the fixation of femoral neck fracture is one of the most important management controversies. The goal of the current study is to compare the short-term outcomes of the femoral neck system (FNS) with multiple cancellous screws (MCS) and dynamic hip screws (DHS) in the treatment of young femoral neck fractures. Methods From June 2018 to June 2021, a total of 120 surgeries for a primary femoral neck fracture were retrospectively analyzed. Demographic data of patient and mechanism of injury were recorded. Also, we recorded the operation time, intraoperative blood loss, time of fluoroscopy and time of hospitalization. Surgical technique was showed. All patients were followed up at 6 weeks, 3 months, 6 months, and 12 months postoperatively. Avascular necrosis of the femoral head (AVN), nonunion, malreduction, implant failure or other complications were noted. The functional status at the last follow-up was assessed using the Harris functional scoring criteria. Results There were 90 males and 30 females, with a mean age of 40.4 years. As to patient characteristics, there were no significant differences between the three groups. DHS group showed longer operation time(52.15 ± 4.80 min), more blood loss(59.05 ± 5.87 ml) and longer time of hospitalization(7.6 ± 0.90 d) than FNS group (39.65 ± 2.84 min, 45.33 ± 9.63 ml and 4.87 ± 0.48 d) and MCS group (39.45 ± 3.10 min, 48.15 ± 7.88 ml and 5.04 ± 0.49 d) (p < 0.05). In addition, the time of fluoroscopy in FNS group (15.45 ± 3.67) was less than that in MCS group (26.3 ± 4.76) and DHS group (27.1 ± 5.67) (p < 0.05). The cost of FNS group(44.51 ± 2.99 thousand RMB) was significantly higher than the MCS and DHS groups. The FNS, MCS and DHS groups showed a similar mean length of femoral neck shortening (LFNS) and Harris score. The FNS, MCS and DHS groups showed a similar mean rate of AVN and internal fixation failure. Conclusions FNS, MCS, and DHS are effective for in the young femoral neck fractures. No difference was found in complications between the three groups. However, a lower time of fluoroscopy of the FNS shortens the operation time. Minimally invasive procedures are associated with less blood loss and less hospital stay. The disadvantage can be an economic burden.
Exploring hybrid models for identifying locations for active mobility pathways using Real-Time Spatial Delphi and GANs
Authors: Calleo Yuri , Giuffrida Nadia , Pilla Francesco 
Published: November 2023

Abstract

The spatial planning process is considered an extremely complex system, as it is made up of different variables that interrelate and interact with each other. Effectively addressing this spatial complexity necessitates a multidisciplinary approach, as unified methodologies may prove insufficient. Specifically, in urban planning, it is increasingly crucial to prioritize bike lanes, bike stations, and pedestrian zones, for functional transportation infrastructures. This approach can enhance cities by improving air quality, reducing emissions, and boosting public health and safety through physical activity and accident prevention. However, implementing these changes requires careful planning, community engagement, and collaboration with stakeholders. This paper proposes a hybrid model for identifying optimal locations for bike lanes, bike stations, and pedestrian zones adopting Real-Time Spatial Delphi and Generative Adversarial Networks (GANs). The Real-Time Spatial Delphi is a modified version of the traditional Delphi method that incorporates real-time feedback and visualization of group response in real-time, aiming to achieve a convergence of opinions among experts on the territory. Nevertheless, these judgments are a spatial representation not visible in reality, and with the spread of AI models, different implementations can support the planning process, such as the use of Generative Adversarial Networks (GANs). In this case, the GANs models can be exploited by adopting pre-existing location images resulting from experts’ judgments to illustrate the proposed intervention’s visual impact. This approach can help stakeholders, policymakers and citizens visualize the proposed changes and assess their potential impact more accurately. To demonstrate the effectiveness of our hybrid model, we apply it to the city of Dublin.
An immune-related prognostic risk model for colorectal cancer was constructed based on next-generation sequencing
Authors: Zhang Zhengxin , Chen Yan , Chen Qianhui , Li Yuhong , Yang Hongbin , Zhang Li , Liu Chengyi , Xu Qian , Liu Lei 
Published: November 2023

Abstract

Objective
Screening the immune-related genes of colorectal cancer based on clinical next generation sequencing and construction of an immune-related prognostic risk model, so as to provide an immediate indicator for evaluating the prognosis and efficacy of immunotherapy of CRC patients.
Methodology:
Univariate and multivariate Cox risk regression analysis was used to analyze the correlation between immune-related genes, clinicopathological features, and prognosis of CRC patients, and a prognostic risk model was established.
Results
A total of 57 mutant genes were detected in 150 CRC patients, of which SNV and Indel had the highest mutation frequency, (92.67% and 47.33%, respectively). The genes with the highest number of mutations were TP53 and APC. In all 150 CRC patients, 12 mutation genes were detected, including 6 drug-treatable genes: KRAS, PIK3CA, PTEN, BRAF, NRAS, and TP53.TP53 and PIK3CA were the genes with the most drug-treatable mutation sites, and KRAS, NRAS, and BRAS had the highest medication grade. The mutation rates of 36 CRC common detection genes in the NGS and TCGA clinical databases were very consistent, and they were enriched in negative regulation of cell proliferation, negative regulation of apoptosis, and kinase pathways such as PI3K-AKT signaling pathway. Through the correlation analysis of immune infiltration, 14 immune-related genes TP53, JAK1, MTHFR, EGFR, KDR, APC, KRAS, TSC2, PMS2, KIT, ALK, BRAF, CTNNB1, and FBXW7 were obtained. The Cox univariate analysis and Cox multivariate analysis showed that late clinical stage (stage), late T stage and ALK gene mutation increased the risk of death and were independent prognostic factors affecting the risk of death. A Cox proportional-hazards model was constructed : h(t,x)/h0(t) = EXP(0.835 clinical stage + 0.878T + 1.094ALK). Among the 112 clinical follow-up patients, the survival time of CRC patients with high-risk scores was significantly shorter than that of CRC patients with low-risk scores. In addition, the risk score of the MSI-L group was significantly higher than that of the MSS group in the 92 CRC patients data sets of the TCGA database.
Conclusion
ALK gene mutation may be related to immune and prognostic survival in CRC patients; the constructed prognostic risk model can be used to evaluate the prognosis and efficacy of immunotherapy in CRC patients.
Multidimensional 3T structural magnetic resonance imaging study of individuals with methamphetamine use disorder: extensive structural abnormalities in frontal cortex and their relationship to cognitive function
Authors: Zhou Yanan , Yang Winson Fu Zun , Wu Qiuxia , Ma Yuejiao , Ren Honghong , Hao Yuzhu , Li Manyun , Wang Yunfei , Peng Pu , Yuan Ning , Xiong Yifan , Wang Yizhuo , Wang Qianjin , Liu Tieqiao 
Published: November 2023

Abstract
Background
Methamphetamine (MA) is widely abused worldwide, but the brain imaging mechanisms underlying its cognitive function are unclear. This study aimed to explore the cognitive function characteristics of individuals with MA use disorders (MUDs) and their relationship with structural brain images from a multidimensional perspective.
Methods
45 MUDs and 43 health control (HCs) were included in this study. The MATRICS Consensus Cognitive Battery was performed to assess the cognitive function among the subjects, and a 3.0T magnetic resonance imaging scanner was utilized for structural data acquisition.
Results
Compared with the HC group, the MUD group had small gray matter volume in the left middle frontal, right insula, left postcentral, and bilateral angular gyrus, while the left superior frontal, left precentral, left postcentral, left supramarginal, left parstriangularis, and left parsopercularis had thin cortical thickness (PFDR-corr < 0.05, cluster > 100). The digit-symbol coding test (DSCT) regression model demonstrated a significant interaction of the group with the cortical thickness of the left parsopercularis (p = 0.04) and left precentral (p = 0.01). For neuropsychology assessment battery-mazes (NAB-Mazes), cortical thickness of the left parsopercularis was positively correlated with NAB-Mazes scores (p = 0.02), and the group interaction was significant (p = 0.001). For the continuous performance test (CPT), cortical thickness of the left superior frontal was negatively correlated with CPT scores (p = 0.03).
Conclusion
MUDs exhibit altered gray matter morphology in several brain regions, where alterations in frontal cortex thickness may underlie the neuroanatomy of cognitive deficits common to MUDs.
Coordinated medical care program for neurofibromatosis type 1 children and adolescents in Poland influences the future of their affected parents: a single academic reference center experience and national program description.
Authors: Karwacki Marek W. 
Published: November 2023

Abstract

Neurofibromatosis type 1 (NF-1) is an inherited neoplastic syndrome. Adults affected by NF-1 in Poland are mostly unaware of the disease-related risk of cancer. During a year since the Ministry of Health settled a national coordinated medical care program for NF-1 children, 388 NF-1 patients up to 30 years of age were admitted to our Center and 187 had an affected parent (48.1% of familial cases). Only 18 NF-1 parents (9.6%) had any knowledge concerning the risk of malignancy, yet 22 (11.7%) were informed about their primary diagnosis for the first time simultaneously with their child. Asymptomatic tumors were revealed in 3 (1.6%) individuals who underwent preventive ultrasonography recommended during the first visit in the Center: abdominal pheochromocytoma in 2 (a 36-year-old man and a 33-year-old woman) and 1b breast cancer in 1 (a 32-year-old woman) case. Concluding, the early successful prevention of malignancy in professionally counselled NF-1 patients, proven currently, necessitates the urgent extension of prophylaxis and coordinated medical care program to the whole NF-1 population, not only in Poland, but worldwide. Precise knowledge concerning the disease-related medical risks should become a subject of the training of medical professionals regardless of their specialty.
Association between the atherogenic index of plasma and coronary collateral circulation in patients with chronic total occlusion
Authors: Dong Shutong , Qiao Jiaming , Gao Ang , Zhao Zehao , Huang Xin , Kan Yi , Yang Zhiqiang , Ma Meishi , Fan Chu , Han Hongya , Zhou Yujie 
Published: November 2023

Abstract

Background: The atherogenicindex of plasma (AIP) isconsidered an independent risk factor for coronary artery disease (CAD). The present study investigated whether AIP correlates with the establishment of coronary collateral circulation (CCC) in CAD patients with chronic total occlusion (CTO).
Methods: This retrospective study included 1093 CAD patients with CTO confirmed by coronary angiography from January 2020 to December 2020 at Beijing Anzhen Hospital. Based on the Rentrop scoring system, the patients were divided into the good CCC group and the poor CCC group. AIP was calculated by log (triglyceride/high-density lipoprotein cholesterol). Meanwhile, the study population was further divided into four groups according to the quartiles of AIP.
Results: Patients in the poor CCC group had significantly higher AIP than those in the good CCC group (0.31 ± 0.27 vs. 0.14 ± 0.24, p < 0.001). Multivariate logistic regression analysis showed that there was an independent association between AIP and poor CCC, regardless of whether AIP was a continuous variable or a categorical variable(p < 0.001), after adjusting for confounding factors. Besides, this association remained stable in most subgroups. By incorporating AIP into the baseline model, the accuracy of identifying poor CCC was improved [AUC: baseline model, 0.661 vs. baseline model + AIP, 0.721, p for comparison < 0.001].
Conclusions: Elevated AIP is independently associated with an increased risk of poor CCC in CAD patients with CTO, and AIP may improve the ability to identify poor CCC in clinical practice.
Allogeneic HSCT for classical BCR::ABL1-negative myeloproliferative neoplasms in children: the retrospective study of the EBMT Pediatric Diseases WP
Authors: Wachowiak Jacek , Galimard Jacques-Emmanuel , Dalissier Arnaud , Rihani Rawad , ALSAEDI HAWAZEN , Wynn Robert , Dalle Jean-Hugues , de Latour Regis Peffault , Sedlacek Petr , Balduzzi Adriana , Schroeder Thomas , Bodova Ivana , Vicent Marta Gonzalez , Gruhn Bernd , Hamladji Rose-Marie , Kriván Gergely , Patrick Katharine , Sobkowiak-Sobierajska Agnieszka , Stepensky Polina , Unal Ali , Amrolia Persis , Perez-Martinez Antonio , Rialland Fanny , Aljurf Mahmoud D , Isgro' Antonella , Toren Amos , Bierings Marc , Corbacioglu Selim , Kalwak Krzysztof 
Published: November 2023

Abstract
This retrospective EBMT registry-based study evaluated 42 children (0.4–18 years, median 6.1) with BCR::ABL1-neg MPN (PMF, n = 33; ET, n = 3; PV, n = 1, sAML, 3; post-ET/PV-MF, n = 2) transplanted from MSD (n = 21) or non-MSD (n = 21) between 2000–2022. Conditioning was usually chemotherapy-based (n = 40; 95.2%) and myeloablative (n = 38; 92.7%). Twenty one patients received HSC from BM, 15 (36%) from PB, and 6 (14%) from CB. Day + 60 CI of neutrophil and platelet recovery was 85.7% and 78.4%. Day + 100 CI of aGvHD II-IV was 35.9% and was lower in transplanted from MSD (20% vs 52.6%, p = 0.03). Six-year CI of cGvHD was 16.6%. Six-year RI was 17.8%, PFS 64.9%, GRFS 49.1%, and OS 68.6%. Six-year RI between 2008–2022 was lower than between 2000–2007 (4.5% vs 30%, p = 0.046). In obtaining BM compared with those transplanted with HSC from BM or CB the 6-year PFS and OS was significantly higher (83.5% vs 51.4%, p = 0.04 and 80.1% vs 48.4%, p = 0.02, respectively), whereas NRM was lower (0% vs 35.3%, p = 0.004). So far, this is the largest and first one multicenter study on transplant-specific characteristics and outcomes of allo-HSCT in children with BCR::ABL1-neg MPN, which indicates need of prospective studies to establish indications for allo-HSCT and optimal transplant procedure in them.