bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Aplikasi Pejabat Pengelolaan Informasi dan Dokumentasi dalam Pelayanan Informasi Publik di Dinas Komunikasi dan Informatika Kabupaten Tanjung Jabung Barat Provinsi Jambi
Authors: Pramesti Anisa Anggun , Mardhatillah Yudha 
Published: October 2023

Judul penelitian yaitu “Efektivitas Aplikasi Pejabat Pengelolaan Informasi dan Dokumentasi Dalam Pelayanan Informasi Publik”. Penelitian ini bertujuan untuk mengetahui keefektifan penerapan aplikasi PPID dalam pelayanan informasi publik serta memahami apa saja yang menjadi kendala serta upayanya. Teori yang digunakan adalah teori efektivitas dari Duncan dimana ada 3 indikator yakni pencapaian tujuan, integrasi, dan adaptasi serta Keputusan Menteri Pendayagunaan Aparatur Negara yang memiliki 4 indikator tentang pelayanan publik yakni prosedur pelayanan, waktu penyelesaian, produk pelayanan, dan kompetensi petugas. Peneliti menggunakan metode deskriptif dengan pendekatan induktif. Sumber datanya ada dua yaitu sumber data primer dan sumber data Adapun Teknik pengumpulan data dilakukan dengan dokumentasi. Teknik analisis data yang digunakan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Mengacu pada hasil pengamatan serta wawancara yang dilakukan, penulis menemukan efektivitas aplikasi pejabat pengelolaan informasi dan dokumentasi dalam pelayanan informasi publik di Dinas Komunikasi dan Informatika Kabupaten Tanjung Jabung Barat masih belum efektif karena masih terdapat banyak kekurangan dan hambatan dalam pelaksanaanya. Keterlambatan pengelolaan permohonan informasi melalui aplikasi PPID, masih kurang dalam pelaksanaan sosialisasi, kurangnya informasi terbaru, serta minimnya fasilitas sarana dan prasarana. Penulis menyarankan Dinas Komunikasi dan Informatika Kabupaten Tanjung Jabung Barat bisa meningkatkan sosialisasi dalam pengoperasian aplikasi PPID ke seluruh OPD di Pemerintahan Kabupaten Tanjung Jabung Barat, kemudian melakukan monitoring serta evaluasi pelayanan informasi publik melalui aplikasi PPID, serta meningkatkan fasilitas SDM dan sarana/prasarana untuk mendukung jalannya aplikasi PPID dalam pelayanan informasi publik yang diperlukan publik.

Kata kunci: Efektivitas, Pejabat Pengelolaan Informasi dan Dokumentasi, Pelayanan Informasi Publik.
Penerapan Aplikasi E-Samsat Dan Sipolin Kantor Cabang Pelayanan Pendapatan Daerah Kota Banjar
Authors: Salama Timoty Yusuf , Tahir Irwan 
Published: October 2023

Penelitian ini memfokuskan untuk mendeskripsikan dan menganalisa Penerapan Aplikasi E-Samsat Dan Sipolin Kantor Cabang Pelayanan Pendapatan Daerah Kota Banjar. Dengan beberapa permasalahan minimnya kesadaran masyarakat Kota Banjar dalm membayar pajak kendraan bermotor, belum jelasnya mekanisme E-Samsat dan Sipolin dan kurangnya pengetahuan masyarakat tentang E-Samsat dan Sipolin. Tujuan dari penelitian ini ialah untuk menganalisis penerapan aplikasi E-Samsat dan Sipolin Kantor Cabang Pelayanan Pendapatan Daerah Kota Banjar. Penelitian ini menggunakan pendekatan deskriptif berdasarkan metode kualitatif. Dalam proses pengumpulan informasi, peneliti melakukan observasi, wawancara, dan menghimpun dokumen terkait penerapan aplikasi E-Samsat dan Sipolin di Kantor Cabang Pelayanan Pendapatan Daerah Kota Banjar. Hasil penelitian menunjukkan bahwa IT Principles berfungsi secara optimal sebagai pendorong dan pengarah (guiding principles) dalam berbagai usaha pemanfaatan IT di organisasi secara umum, khususnya E-Samsat dan Sipolin. Integrasi dan standarisasi dari Sistem aplikasi E-Samsat dan Sipolin Kota Banjar sudah sesuai dengan IT architecture decisions. IT infrastructure meliputi Prasarana dan fasilitas teknologi informasi yang berkaitan dengan jaringan, komputer, perangkat lain, dan perangkat lunak merupakan sekumpulan komponen yang diharapkan dapat mempercepat proses komputasi dan transmisi dalam waktu singkat dalam berbagai media. Proses pendaftaran efisien, aplikasi busseness needs pada sistem E-Samsat dan Sipolin yang dilaksanakan CPDPDP Wilayah Kota Banjar, dalam penerapannya memang membutuhkan kreativitas dan disiplin guna mewujudkan nilai baru bagi organisasi yang berdampak pada pelayanan prima pada masyarakat serta berkaitan dengan IT Investment and prioritization diketahui bahwa dalam penerapan E-Samsat dan Sipolin di CPDPDP Wilayah Kota Banjar, pelaksanaannya sudah menjalankan inisiatif yang perlu diprioritaskan. Kesimpulannya bahwa penerapan aplikasi E-Samsat dan Sipolin Kantor Cabang Pelayanan Pendapatan Daerah Kota Banjar sudah sesuai dengan aturan dan kebijakan dari pusat, namun masih memiliki kendala dalam ketersediaan anggaran.
Kata kunci: E-Samsat, Sipolin, Pelayanan Pendapatan Daerah.
The Effect of Dysmenorrhea Gymnastics on the Pain Scale of Dysmenorrhea in Young Women in Youth Development Social Services (PSBR)
Authors: Ekapuspitasari Dita Yanuar , Sari Yeni Kartika , Widigdo Trio 
Published: October 2023

Teenager women experience growth and development, one of which is characterized by the occurrence of haid. Dysmenorrhoea is often found at the beginning of menstruation young women experience menstrual pain. Exercise in this case gymnastics dysmenorrhea is shown to increase b-endorphin 4 to 5 times in the blood. Data obtained from the youth poly of UPT Puskesmas Kec. Sananwetan in September 2020 showed that 2 out of 5 PSBR teenagers who came to the UPT Puskesmas Kec. Sananwetan experienced complaints of dysmenorrhea every month. Research aims to determine the effect of giving Dysmenorrhea gymnastics on young women in PSBR Blitar City. This study included a quasi-experimental study with a population of 35 young women and samplingusing Purposive Sampling. Based on the results of a study conducted using a dependent T-test statistical test (dependent T-test), the time of dysmenorrhea pain before dysmenorrhea gymnastics in young women was 4 (16%) adolescents experiencing mild dysmenorrhea pain, 12 (48%) adolescents experiencing moderate pain, and 9 (36%) adolescents experiencing severe pain scale, dysmenorrhea pain scale after dysmenorrhea gymnastics in young women is 3 (12%) adolescents do not experience dysmenorrhea pain, 22 (88%) adolescents experience moderate pain. This study proves that dysmenorrheagymnastics has a significant influence on the scale of dysmenorrhea pain in adolescents in the Social Service of Youth Development (PSBR) of Blitar City.
Association between weight-adjusted-waist index and the risk of hyperuricemia in adults: a population-based investigation
Authors: Ding Yunyi , Xu Zhuohan , Zhou Xue , Luo Yichen , Xie Ruijie , Li Yayu 
Published: October 2023

ObjectiveThis investigation sought to elucidate the potential correlation between a recently characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and hyperuricemia.MethodsA cross-sectional design was employed in this study, featuring both hyperuricemic and non-hyperuricemic subjects with complete WWI data, sourced from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to March 2020. WWI was calculated utilizing the formula which involves the division of waist circumference (WC) by the square root of the body weight. In order to determine the relationship between WWI and hyperuricemia, both univariate and multivariate logistic regression models, appropriately weighted, were employed in the analysis. The linearity of relationships was validated using smooth curve fitting. Additionally, subgroup evaluations and interaction assessments were conducted.ResultsThe study sample comprised 7437 subjects, yielding a hyperuricemia prevalence of 18.22%. Stratifying WWI into tertiles, a progressive rise in hyperuricemia prevalence was evident with increasing WWI (Tertile 1: 11.62%, Tertile 2: 17.91%, Tertile 3: 25.13%). The odds ratio (OR) demonstrated that individuals within the highest WWI tertile were significantly more prone to hyperuricemia than those in the lowest tertile (OR = 2.41, 95% CI: 1.88-3.08).ConclusionThis study provides evidence that an elevated WWI is correlated with an increased risk of hyperuricemia in the adult population of the United States. These results suggest that WWI may serve as a viable anthropometric indicator for predicting hyperuricemia.
Causal effects of walking pace on osteoarthritis: a two-sample mendelian randomization study
Authors: Qiu Peng , Wu Junyu , Kui Lihong , Chen Mingxian , Lv Shuaibing , Zhang Zhongkai 
Published: October 2023

Background: Osteoarthritis (OA) is one of the most common joint diseases worldwide, imposing a substantial burden on individuals and society. Numerous pieces of evidence suggest that walking pace (WP) can serve as a predictive indicator for the risk of various diseases, and observational studies have also found a potential link between WP and the risk of OA. However, the causal relationship between WP and the risk of OA remains unclear.Methods: We conducted a mendelian randomization (MR) study using data from the European Genome-wide Association Study, which included WP (including 459,915 participants), OA (including 10,083 cases and 40,425 controls), knee OA (including 24,955 cases and 378,169 controls), and hip OA (including 15,704 cases and 378,169 controls). Single nucleotide polymorphisms (SNPs) associated with WP were utilized to infer causal associations with OA and its subtypes. The Inverse Variance Weighted (IVW) technique served as the primary causal analysis method. Three auxiliary MR methods - MR-Egger, weighted median, and maximum likelihood - were used to substantiate the IVW results. Sensitivity analyses were performed to examine heterogeneity and pleiotropy. In addition, multivariate MR (MVMR) analysis was used to assess causality after adjustment for three potential confounders.Results: According to the results of the IVW method, every 1 standard deviation increased in genetic WP corresponds to an 89% reduction in the risk of OA (odds ratio (OR) = 0.11; 95% confidence interval (CI), 0. 06–0.19; p = 1.57 × 10−13), an 83% reduction in the risk of knee OA (OR = 0.17; 95% CI, 0.11–0.28; p = 2.78 × 10−13), and a 76% reduction in the risk of hip OA (OR = 0.24; 95% CI, 0.14–0.43; p = 1.51 × 10−6). These results were confirmed by the three additional MR methods and validated by the sensitivity analysis. Ultimately, the MVMR analysis confirmed that the role of WP in reducing the risk of OA and its subtypes remains consistent regardless of potential confounders.Conclusion: The results of our MR study highlight a significant causal association between WP and the susceptibility to OA, including its knee and hip subtypes. These findings propose that WP could be utilized as a potential prognostic factor for OA risk.
Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection
Authors: Brady Tyler , Cayatte Corinne , Roe Tiffany L. , Speer Scott D. , Ji Hong , Machiesky LeeAnn , Zhang Tianhui , Wilkins Deidre , Tuffy Kevin M. , Kelly Elizabeth J. 
Published: October 2023

IntroductionNirsevimab is an extended half-life (M252Y/S254T/T256E [YTE]-modified) monoclonal antibody to the pre-fusion conformation of the respiratory syncytial virus (RSV) Fusion protein, with established efficacy in preventing RSV-associated lower respiratory tract infection in infants for the duration of a typical RSV season. Previous studies suggest that nirsevimab confers protection via direct virus neutralization. Here we use preclinical models to explore whether fragment crystallizable (Fc)-mediated effector functions contribute to nirsevimab-mediated protection.MethodsNirsevimab, MEDI8897* (i.e., nirsevimab without the YTE modification), and MEDI8897*-TM (i.e., MEDI8897* without Fc effector functions) binding to Fc γ receptors (FcγRs) was evaluated using surface plasmon resonance. Antibody-dependent neutrophil phagocytosis (ADNP), antibody-dependent cellular phagocytosis (ADCP), antibody-dependent complement deposition (ADCD), and antibody-dependent cellular cytotoxicity (ADCC) were assessed through in vitro and ex vivo serological analyses. A cotton rat challenge study was performed with MEDI8897* and MEDI8897*-TM to explore whether Fc effector functions contribute to protection from RSV.ResultsNirsevimab and MEDI8897* exhibited binding to a range of FcγRs, with expected reductions in FcγR binding affinities observed for MEDI8897*-TM. Nirsevimab exhibited in vitro ADNP, ADCP, ADCD, and ADCC activity above background levels, and similar ADNP, ADCP, and ADCD activity to palivizumab. Nirsevimab administration increased ex vivo ADNP, ADCP, and ADCD activity in participant serum from the MELODY study (NCT03979313). However, ADCC levels remained similar between nirsevimab and placebo. MEDI8897* and MEDI8897*-TM exhibited similar dose-dependent reduction in lung and nasal turbinate RSV titers in the cotton rat model.ConclusionNirsevimab possesses Fc effector activity comparable with the current standard of care, palivizumab. However, despite possessing the capacity for Fc effector activity, data from RSV challenge experiments illustrate that nirsevimab-mediated protection is primarily dependent on direct virus neutralization.
Case report: Genotype-phenotype characteristics of nine novel PKD1 mutations in eight Chinese patients with autosomal dominant polycystic kidney disease
Authors: Zhuang Jing , Aierken Ailima , Yalikun Dilina , Zhang Jun , Wang Xiaoqin , Ren Yongfang , Tian Xuefei , Jiang Hong 
Published: October 2023

IntroductionAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder. The PKD1 gene is responsible for the majority of ADPKD cases, and the mutations in this gene exhibit high genetic diversity. This study aimed to investigate the association between genotype and phenotype in ADPKD patients with PKD1 gene mutations through pedigree analysis.MethodsEight Chinese pedigrees affected by ADPKD were analyzed using whole-exome sequencing (WES) on peripheral blood DNA. The identified variants were validated using Sanger sequencing, and clinical data from the patients and their families were collected and analyzed.ResultsNine novel mutation sites in PKD1 were discovered across the pedigrees, including c.4247T &gt; G, c.3298_3301delGAGT, c.4798A &gt; G, c.7567G &gt; A, c.11717G &gt; C, c.7703 + 5G &gt; C, c.3296G &gt; A, c.8515_8516insG, and c.5524C &gt; A. These mutations were found to be associated with a range of clinical phenotypes, including chronic kidney disease, hypertension, and polycystic liver. The age of onset and disease progression displayed significant heterogeneity among the pedigrees, with some individuals exhibiting early onset and rapid disease progression, while others remained asymptomatic or had milder disease symptoms. Inheritance patterns supported autosomal dominant inheritance, as affected individuals inherited the mutations from affected parents. However, there were instances of individuals carrying the mutations who remained asymptomatic or exhibited milder disease phenotypes.ConclusionThis study highlights the importance of comprehensive genotype analysis in understanding the progression and prognosis of ADPKD. The identification of novel mutation sites expands our knowledge of PKD1 gene mutations. These findings contribute to a better understanding of the disease and may have implications for personalized therapeutic strategies.
Relationship between rumen bacterial community and milk fat in dairy cows
Authors: Si Boxue , Liu Kaizhen , Huang Guoxin , Chen Meiqing , Yang Jiyong , Wu Xufang , Li Ning , Tang Wenhao , Zhao Shengguo , Zheng Nan , Zhang Yangdong , Wang Jiaqi 
Published: October 2023

IntroductionMilk fat is the most variable nutrient in milk, and recent studies have shown that rumen bacteria are closely related to milk fat. However, there is limited research on the relationship between rumen bacteria and milk fatty. Fatty acids (FAs) are an important component of milk fat and are associated with various potential benefits and risks to human health.MethodsIn this experiment, forty-five healthy Holstein dairy cows with alike physiological and productive conditions were selected from medium-sized dairy farms and raised under the same feeding and management conditions. The experimental period was two weeks. During the experiment, raw milk and rumen fluid were collected, and milk components were determined. In this study, 8 high milk fat percentage (HF) dairy cows and 8 low milk fat percentage (LF) dairy cows were selected for analysis.ResultsResults showed that the milk fat percentage in HF group was significantly greater than that of the dairy cows in the LF group. 16S rRNA gene sequencing showed that the rumen bacterial abundance of HF dairy cows was significantly higher than that in LF dairy cows; at the genus level, the bacterial abundances of Prevotellaceae_UCG-001, Candidatus_Saccharimonas, Prevotellaceae_UCG-003, Ruminococcus_1, Lachnospiraceae_XPB1014_group, Lachnospiraceae_AC2044_group, probable_genus_10 and U29-B03 in HF group were significantly higher than those in the LF group. Spearman rank correlation analysis indicated that milk fat percentage was positively related to Prevotellaceae_UCG-001, Candidatus_Saccharimonas, Prevotellaceae_UCG-003, Ruminococcus_1, Lachnospiraceae_XPB1014_group, Lachnospiraceae_AC2044_group, probable_genus_10 and U29-B03. Furthermore, Prevotellaceae_UCG-001 was positively related to C14:0 iso, C15:0 iso, C18:0, Ruminococcus_1 with C18:1 t9, Lachnospiraceae_AC2044_group with C18:1 t9 and C18:1 t11, U29-B03 with C15:0 iso.DiscussionTo sum up, rumen bacteria in dairy cows are related to the variation of milk fat, and some rumen bacteria have potential effects on the deposition of certain fatty acids in raw milk.
Benefits of using digital thoracic drainage systems for post-operative treatment in pediatric populations: personal experience and review of literature
Authors: Frediani Simone , Romano Giorgia , Pardi Valerio , Aloi Ivan Pietro , Bertocchini Arianna , Accinni Antonella , Zarfati Angelo , Inserra Alessandro 
Published: October 2023

IntroductionThe digital chest drainage monitoring system (Medela Thopaz+), unlike analogical systems, reliably regulates the pressure applied to the patient's chest and digitally and silently monitors critical therapeutic indicators (volume of fluid and/or drained air). Its use in adulthood has been widely described, but there is still little experience in the pediatric field. The aim of this study is to test this new device in the pediatric population.Materials and methodsWe conducted a retrospective study of 160 patients undergoing chest surgery at our Hospital. These patients were divided into 82 treated with the Thopaz system in the period from January 2021 to April 2023 and 78 in whom Pleurevac, had been used in the time period from January 2020 to April 2023.ResultsThe average age of patients was 10.45 years (range: 3.1–17.2) for the Thopaz Group and 10.71 years for Pleurevac Group. The groups were homogeneus also by weight and type of intervention. The device was held in place for 10.64 days (mean) for Thopaz Group, compared to 16.87 days (mean) for Pleurevac Group (p &lt; 0.05). The median number of postoperative x-rays before the closure of the chest tube was 4.29 in the digital drainage group compared to 8.41 in the traditional draining group (p &lt; 0.05).ConclusionsThe digital chest monitoring device provides objective measurement, allows for rapid patient mobilization (with good pain control and increased compliance). In addition, the use of Thopaz in the paediatric population seems to be safe (there is no statistically significant difference in terms of complications such as prolonged air leaks and pneumothorax after the chest tube closure) and potentially beneficial.
Tanshinone IIA alleviates atherosclerosis in LDLR−/− mice by regulating efferocytosis of macrophages
Authors: Wang Jiarou , Zhang Yifan , Feng Xiaoteng , Du Min , Li Sijin , Chang Xindi , Liu Ping 
Published: October 2023

Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS). However, it remains unclear whether TIIA has the potential to enhance macrophage efferocytosis and thereby improve atherosclerosis.Objective: The focus of this examination was to determine if TIIA could reduce lipid accumulation and treat AS by enhancing efferocytosis.Methods: Firstly, we conducted in vivo experiments using LDLR knockout (LDLR−/−) mice for a period of 24 weeks, using histopathological staining, immunofluorescence and Western blot experiments to validate from the efficacy and mechanism parts, respectively; in addition, we utilized cells to validate our study again in vitro. The specific experimental design scheme is as follows: In vivo, Western diet-fed LDLR−/− mice for 12 weeks were constructed as an AS model, and normal diet-fed LDLR−/− mice were taken as a blank control group. The TIIA group and positive control group (atorvastatin, ATO) were intervened for 12 weeks by intraperitoneal injection (15 mg/kg/d) and gavage (1.3 mg/kg/d), respectively. In vitro, RAW264.7 cells were cultured with ox-LDL (50 ug/mL) or ox-LDL (50 ug/mL) + TIIA (20 uM/L or 40 uM/L). Pathological changes in aortic plaques and foam cell formation in RAW264.7 cells were evaluated using Masson and Oil Red O staining, respectively. Biochemical methods were used to detect lipid levels in mice. The immunofluorescence assay was performed to detect apoptotic cells and efferocytosis-related signal expression at the plaques. RT-qPCR and Western blot were carried out to observe the trend change of efferocytosis-related molecules in both mouse aorta and RAW264.7 cells. We also used the neutral red assay to assess RAW264.7 cells’ phagocytic capacity.Results: Compared with the model group, TIIA decreased serum TC, TG, and LDL-C levels (p &lt; 0.01), reduced the relative lumen area of murine aortic lipid-rich plaques (p &lt; 0.01), enhanced the stability of murine aortic plaques (p &lt; 0.01), reduced ox-LDL-induced lipid build-up in RAW264.7 cells (p &lt; 0.01), and upregulated efferocytosis-related molecules expression and enhance the efferocytosis rate of ox-LDL-induced RAW264.7 cells.Conclusion: TIIA might reduce lipid accumulation by enhancing the efferocytosis of macrophages and thus treat AS.