bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of different concentrations of chlorhexidine-iodophor composite solution on human skin fibroblasts
Authors: YiXin Luo , ShaoNa Niu , LiFang Mai , XingZhou Liu , Chuan Yang 
Published: February 2024

Objective: Chlorhexidine-iodophor (CHX-IP) composite solution is a polymer of chlorhexidine and iodophor produced with new technology, for use in diabetic foot infection. However, the effect of CHX-IP on the growth activity of fibroblasts remains unknown, thus the effects of different concentrations of CHX-IP composite solution on the viability and micromorphology of human skin fibroblasts were studied in vitro cell culture in this study. Method: A cell viability assay was applied to calculate cell viability and an inverted fluorescence microscope was used to observe cell morphology over five days. Results: The results showed that the toxic effect of CHX-IP on fibroblasts was solution concentration-dependent and decreased over time. When the concentration of CHX-IP was 5.0mg/ml, 2.5mg/ml, 0.625mg/ml, 0.15625mg/ml, 0.078125mg/ml or 0mg/ml, the difference of optical density (OD) value on different days was statistically significant (p<0.05). There were statistically significant differences in the OD value of fibroblasts among different concentrations of CHX-IP on: day 2 (F=4.809, p=0.004); day 3 (F=21.508, p<0.001); day 4 (F=63.952, p<0.001); and day 5 (F=160.407, p<0.001). In addition, a concentration of 5.0mg/ml CHX-IP resulted in a fibroblastic viability rate of 0% on day 4, when CHX-IP was diluted to 2.5mg/ml or 1.25 mg/ml, fibroblastic viability rate decreased to 0% day 5. However, when the CHX-IP was diluted to 0.15625mg/ml or 0.078125mg/ml, the fibroblastic cell viability rate increased slightly on day 5. The morphology of cells observed under microscope indirectly supported this result. Conclusion: The findings of this study showed that the toxic effect of CHX-IP on fibroblasts was solution concentration-dependent and decreased over time.
Hybrid air-bulk multi-pass cell compressor for high pulse energies with full spatio-temporal characterization
Authors: Omar Alan , Hoffmann Martin , Galle Geoffrey , Sylla François , Saraceno Clara J. 
Published: February 2024

Multi-pass cell (MPC) compressors have proven to be the method of choice for compression of high average power long-pulse Yb lasers. Yet, generating sub-30 fs pulses at high pulse energy with compact and simple components remains a challenge. This work demonstrates an efficient and cost-effective approach for nonlinear pulse compression at high pulse energy using a hybrid air-bulk MPC. By carefully balancing the relative nonlinear contributions of ambient air and fused silica, we achieve strong spectral broadening without dispersion engineering or pressure-control inside the cell at 400-µJ pulse energy. In this way, we compress pulses from 220 fs to 27 fs at 40.3 W of average power (100 kHz repetition rate), enhancing the peak power from 1.6 GW to 10.2 GW while maintaining 78% of the energy within the main pulse. Our approach combines the strengths of gas-filled and bulk compression schemes and exhibits excellent overall optical transmission (91%) and spectral uniformity. Moreover, we utilize the INSIGHT technique to investigate spatio-temporal couplings and geometrical aberrations of the compressed pulse. Our results demonstrate remarkable temporal homogeneity, with an average Strehl ratio of 0.97 consistently observed throughout the entire spectral profile. Additionally, all spectrally-integrated Zernike coefficients for geometrical aberrations maintain values below 0.02λ.
The effect of obligatory Padua prediction scoring in hospitalized medically ill patients: A retrospective cohort study
Authors: Drozdinsky Genady , Zusman Oren , Kushnir Shiri , Leibovici Leonard , Gafter-Gvili Anat 
Published: February 2024

Background
Venous thromboembolism (VTE) is considered a preventable cause of mortality. The evidence for the benefit of VTE prophylaxis in acute medical patients is non-conclusive. Meta-analysis of RCTs failed to demonstrate reduction of all-cause mortality, while showing higher risk of bleeding. The Israeli Ministry of Health has instructed to assess all acute medical patients for the risk for VTE using the Padua Prediction Score, without mandating prophylaxis.

Aim
To evaluate the effect of filling the Padua score on clinical outcomes and VTE prophylaxis rates.

Methods
Retrospective Study was performed in Israel during the years 2014–2017. The participants were divided to Padua compliance vs non-compliance group. Primary outcome: 30-day mortality. Secondary outcomes: 90-day incidence of VTE and suspected major bleeding. A propensity-weighted logistic multiple regression was performed.

Results
18,890 patients were included in the study. The fulfillment of the Padua score was associated with an increased use of VTE prophylaxis, OR 1.66 (95% CI 1.49–1.84). However, there was no reduction of mortality or VTE events, OR 1.13 (95% CI 0.97–1.31) and OR 1.22 (95% CI 0.79–1.8) respectively. Hospitalizations related to hemoglobin decrease were not statistically different between the two groups.

Conclusions
Padua score for the assessment of VTE risk in medical wards was associated with higher administration of pharmacological prophylaxis without reduction in VTE or mortality rate. Its usage should be reassessed as a performance measure.
Frailty before and during austerity: A time series analysis of the English Longitudinal Study of Ageing 2002–2018
Authors: Pugh Carys , Eke Chima , Seth Sohan , Guthrie Bruce , Marshall Alan 
Published: February 2024

Background
Frailty is characterised by a reduced resilience to adversity. In this analysis we examined changes in frailty in people aged 50+ before and during a period of austere public spending in England.

Methods
Data from the English Longitudinal Study of Ageing 2002–2018 were analysed. Associations between austerity and frailty were examined using (1) Multilevel interrupted times series analysis (ITSA); and (2) Accelerated longitudinal modelling comparing frailty trajectories in people of the same age in 2002 and 2012.

Results
The analysis included 16,410 people (mean age 67 years, 55% women), with mean frailty index score of 0.16. Mean scores in women (0.16) where higher than in men (mean 0.14), and higher in the poorest tertile (mean 0.20) than the richest (mean 0.12). In the ITSA, frailty index scores increased more quickly during austerity than before, with the additional increase in frailty 2012–2018 being similar in magnitude to the difference in mean frailty score between people aged 65–69 and 70–74 years. Steeper increases in frailty after 2012 were experienced across the wealth–spectrum and in both sexes but were greater in the very oldest (80+). In the accelerated longitudinal analysis, frailty was lower in 2012 than 2002, but increased more rapidly in the 2012 cohort compared to the 2002 cohort; markedly so in people aged 80+.

Conclusion
The period of austerity politics was associated with steeper increases in frailty with age compared to the pre–austerity period, consistent with previously observed increases in mortality.
Experiences of being treated with autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: A qualitative interview study
Authors: Tolf Andreas , Gauffin Helena , Burman Joachim , Landtblom Anne-Marie , Flensner Gullvi 
Published: February 2024

Background
Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used as a treatment for aggressive multiple sclerosis (MS) and has the potential to induce long-term remission and resolution of disease activity. Despite the extensive research on treatment outcome after AHSCT, the experience of living with MS after AHSCT has not been previously described in the scientific literature. The aim of this study was to explore long-term lived experience of people with MS treated with AHSCT.

Methods and findings
To exclude selection bias, all persons treated with AHSCT for MS at Uppsala University Hospital, Sweden, between 2004 and 2007 (n = 10), were asked to participate in the study, and all accepted. Open-ended interviews were conducted, digitally recorded, transcribed verbatim, and then subjected to qualitative content analysis with an inductive approach. Five main themes emerged from the interviews: (I) being diagnosed with MS–an unpredictable existence; (II) a new treatment–a possibility for a new life; (III) AHSCT–a transition; (IV) reclaiming life; and (V) a bright future accompanied by insecurity. AHSCT was described by the participants in terms of a second chance and an opportunity for a new life. The treatment became a transition from a state of illness to a state of health, enabling a previous profound uncertainty to wane and normality to be restored. Although participants of different age and sex were included, the main limitation of this study is the relatively small number of participants. Also, the inclusion of persons from one centre alone could restrict transferability of the results.

Conclusions
The results give a first insight into lived experience following a highly effective induction treatment for MS, and the experience of not having MS anymore. Underpinned by previously described outcome following AHSCT, the results of this study challenge the current view on MS as a chronic disease with no possible cure.
ANALYSIS OF DEMOGRAPHIC INDICATORS IN AGRICULTURE-BASED AND RAW MATERIALS-BASED REGIONS OF THE RUSSIAN FEDERATION
Authors: Danilova S. V. , Maslikhova E. A. , Maratkanova I. V. 
Published: February 2024

In recent decades, there has been some reduction in the working age population in most regions of the Russian Federation (influenced by the “demographic pit” of the 90s of the 20th century). The decline in the population is certainly a negative factor in the socio-economic development of any territory. The present study conducted a comparative analysis of the main demographic indicators of the two regions — agriculture-based (Altai region) and raw materials-based (Khanty-Mansi autonomous region — Ugra). The choice of these constituent entities of the Russian Federation is due to their specialization, industry, agriculture, food industry, oil and gas production are the main groups of economic progress of the entire state. The analysis of demographic processes was based on the data posted in official open sources (Federal State Statistics Service).
According to the authors, without the sufficient number of working age population, without maintaining the optimal ratio of men and women, the level of marriage, the number of women of fertile age, the development rate of the territories will decrease. Preserving the population, increasing the birth rate and life expectancy is the main task of the authorities, which is reflected in the programs of socio-economic development approved by all levels of government of the Russian Federation.
КВАЛІМЕТРИЧНА ОЦІНКА ФАКТОРІВ ПОРУШЕНЬ ОПОРНО-РУХОВОГО АПАРАТУ У ЮНИХ СПОРТСМЕНІВ-ЧЕРЛІДЕРІВ НА ЕТАПІ ПОЧАТКОВОЇ ПІДГОТОВКИ
Authors: Юрій Крикун , Вако Ілля , Довганінець Олег 
Published: February 2024

Мета. Визначити структуру факторів, які призводять до порушень опорно-рухового апарату в навчально-тренувальному процесі на етапі початкової підготовки (на прикладі черліденгу). Методи. Для досягнення поставленої мети використали аналіз документальних матеріалів, кваліметрію – метод експертних оцінок. Експертну оцінку проводили за участю 19 експертів (тренерів зі стажем 5 років) Всеукраїнської федерації черліденгу груп підтримки спортивних команд. При проведенні експертизи методом надання переваги розрахункове значення коефіцієнта конкордації W становило 0,85 при (p < 0,05), тобто результатам проведеної експертизи можна довіряти, саму експертизу можна вважати такою, що відбулася, а думку експертів – узгодженою. Результати. Дослідження показало, що головними причинами, які призводять до порушень опорно-рухового апарату юних черлідерів на етапі початкової підготовки, а відтак і низької ефективності тренувального процесу є відсутність системи профілактики функціональних порушень (перше рангове місце) та незначна увага тренерів до функціонального стану опорно-рухового апарату юних (друге рангове місце). Висновок. Отже, проведена експертна оцінка дозволила виокремити найголовніші фактори (відсутність обґрунтованих технологій профілактики функціональних порушень опорно-рухового апарату юних черлідерів, незначна увага тренерів до функціонального стану опорно-рухового апарату юних черлідерів), які негативно впливають на опорно-руховий апарат під час навчально-тренувальних занять.
ЗМІСТ ЦІЛЬОВИХ СОЦІАЛЬНИХ ПРОГРАМ РОЗВИТКУ ФІЗИЧНОЇ КУЛЬТУРИ ТА СПОРТУ В ІВАНО-ФРАНКІВСЬКІЙ ОБЛАСТІ
Authors: Лисейко Костянтин , Яців Ярослав , Пітин Мар’ян 
Published: February 2024

Мета: вивчити досвід планування цільової соціальної програми розвитку фізичної культури та спорту в Івано-Франківській області.
Методи: теоретичний аналіз та узагальнення та аналіз документальних матеріалів.
Результати. Подальший розвиток фізичної культури та спорту на місцевому рівні зіткнувся зі значними ускладненнями внаслідок дії кризових явищ для сучасного українського суспільства. Тому актуальним є вивчення досвіду планування цільової соціальної програми розвитку фізичної культури та спорту в Івано-франківській області. Механізми державного регулювання фізичної культури та спорту будуються на засадах децентралізації. Серед основних напрямів розвитку фізичної культури та спорту в Івана-Франківській області після 2016 року відбулися певні структурні та змістові зміни, які в більшій мірі відображаються специфіку предметної сфери діяльності за визначеним напрямом.
Висновки. Для Програм розвитку фізичної культури та спорту в межах Івано-Франківської області упродовж 2012−2022 рр. Виявлено сталість визначень та формулювань базових положень при цьому фінансове забезпечення реалізації напрямів в їхніх межах систематично зростає. В окремих періодах систематично збільшується на 3,16−12,47%, проте спостерігаються роки найбільших відсоткових змін 36,48 та 109,57% порівняно з останнім роком попереднього періоду планування.
Probabilistic Linkage Creates a Novel Database to Study Bronchiolitis Care in the PICU
Authors: Flaherty Brian F. , Smith Mckenna , Dziorny Adam , Srivastava Rajendu , Cook Lawrence J. , Keenan Heather T. 
Published: February 2024

OBJECTIVES
Lack of a comprehensive database containing diagnosis, patient and clinical characteristics, diagnostics, treatments, and outcomes limits needed comparative effectiveness research (CER) to improve care in the PICU. Combined, the Pediatric Hospital Information System (PHIS) and Virtual Pediatric Systems (VPS) databases contain the needed data for CER, but limits on the use of patient identifiers have thus far prevented linkage of these databases with traditional linkage methods. Focusing on the subgroup of patients with bronchiolitis, we aim to show that probabilistic linkage methods accurately link data from PHIS and VPS without the need for patient identifiers to create the database needed for CER.

METHODS
We used probabilistic linkage to link PHIS and VPS records for patients admitted to a tertiary children’s hospital between July 1, 2017 to June 30, 2019. We calculated the percentage of matched records, rate of false-positive matches, and compared demographics between matched and unmatched subjects with bronchiolitis.

RESULTS
We linked 839 of 920 (91%) records with 4 (0.5%) false-positive matches. We found no differences in age (P = .76), presence of comorbidities (P = .16), admission illness severity (P = .44), intubation rate (P = .41), or PICU stay length (P = .36) between linked and unlinked subjects.

CONCLUSIONS
Probabilistic linkage creates an accurate and representative combined VPS-PHIS database of patients with bronchiolitis. Our methods are scalable to join data from the 38 hospitals that jointly contribute to PHIS and VPS, creating a national database of diagnostics, treatment, outcome, and patient and clinical data to enable CER for bronchiolitis and other conditions cared for in the PICU.
Analysis of endogenous benzoic acid content in different jujube varieties, maturity stages, and processing types: Implications for the agri-food industry
Authors: Zheng X.D. , Pan S.X. , Cao N. , Yan X.H. , Liu X.M. , Tan M.N. , Wu M.Y. , Song Y. 
Published: February 2024

AbstractBenzoic acid naturally exists in a variety of plants and fermented foods, and jujube contains natural benzoic acid. This study scrutinises the content of benzoic acid in diverse jujube cultivars, and its modulation by variables such as harvest timing, product types, and drying techniques. The methodology encompasses tracking the progressive augmentation of benzoic acid throughout the maturation process of jujube, with the apex content being 144.4 mg kg−1 in the Junzao cultivar. It further investigates the substantial fluctuations in benzoic acid content in jujube powder under disparate processing conditions, with the zenith content observed in drum-dried jujube powder at 127.6 mg kg−1, and an unexpectedly elevated level of 66.2 mg kg−1 in freeze-dried jujube powder. As long as it is not consumed excessively, it will not cause harm to the human body. The conclusion drawn from this research posits can be employed to resolve consumer grievances, or as a benchmark for testing services for product quality control.
Experimental study of failure of glulam-concrete composite beams
Authors: Juhász Tamás , Lee Yishi , Holtzman Rose , Balogh Jeno 
Published: February 2024

AbstractThis paper is dedicated to the memory of Dr. Miklós Iványi, who instilled in the authors an appreciation for experimental investigations, which are foundational to understanding material and structural behavior. Timber-concrete composite structures are increasingly adopted for new buildings due to their favorable sustainability parameters and the increased availability of cross laminated timber. For larger spans, however, solid timber floors lead to higher timber volumes and the use of glulam beams may become necessary for a more efficient use of wood. This paper presents laboratory tests of glulam-concrete composite beams and is the first in a series of two papers on investigating the associated failure mechanisms. Three full-scale glulam-concrete beam specimens were studied. The glulam and concrete are monolithically interconnected using a continuous layer of adhesive. Shear reinforcement was added to the glulam beams to allow for failure mode control. Static load tests to failure were conducted along with acoustic emission monitoring to track the progression of the failure. The results indicate that the shear reinforcement of the glulam layer affects the load capacity of the composite beam through shifting the failure from a shear to a tension failure mode. Similar glulam-concrete beams can enable larger span applications for buildings and bridges while maintaining an attractive sustainability performance.
ANALYSIS OF THE APPLICATION OF THE STATEMENT OF FINANCIAL ACCOUNTING STANDARDS (PSAK) 106 CONCERNING MUSYARAKAH FINANCING AT BANK BRI SYARIAH BRANCH OFFICE BANDUNG CITARUM
Authors: Hardiansyah Dimas , Aufa In’amul 
Published: February 2024

AbstractThis study aims to determine the suitability of applying accounting treatment regarding the recognition, measurement, presentation, and disclosure of financial statements of musyarakah financing transactions with PSAK No. 106 at BRI Syariah Branch Office Bandung Citarum in 2019. This research is a field study with a qualitative approach. The subject of research is at BRI Syariah Branch Office Bandung Citarum. In contrast, the object of research is the recognition, measurement, presentation, and disclosure of financial statements of musyarakah financing transactions in 2019. Data collection techniques in research using interviews and documentation. The results of this study show that : (1) the recognition of musyarakah financing accounting is not entirely by PSAK No. 106 because profit sharing income is calculated based on projections and losses due to accidents are the responsibility of customers, with discounts given; (2) accounting measurement of musyarakah financing by PSAK No. 106; (3) the presentation of musyarakah financing accounting is not by PSAK No. 106 because the cash handed over to customers is presented as musyarakah financing: (4) the disclosure of musyarakah financing accounting is not by PSAK No. 106 because BRI Syariah Branch Office Bandung Citarum does not make notes to the financial statements.Keywords: Musyarakah Financing, Statement of Financial Accounting Standards (PSAK) No. 1
Assessment of compassion and empathy in students of health care professions
Authors: Rao Nallapu Samson Sanjeeva , Bhanu Sundeep G. 
Published: February 2024

Compassion is one of the most important qualities expected and anticipated by patients from their healthcare professionals. Empathy is the ability to recognize and respond to others’ emotions. What differentiates compassion from empathy is the creation of a strong desire to reduce suffering. To assess and compare compassion levels in students of MBBS, BSc Nursing and Bachelors in Physiotherapy (BPT) in a medical college. This is a descriptive study done at the NRI Medical College in Guntur district of Andhra Pradesh state in India, The study involved students of 6 Semester MBBS (126), BSc Nursing 4 year (89) and 4 year BPT (48). The study instruments included the Compassion Score questionnaire & Toronto Empathy Questionnaire (TEQ) 3 which are both available freely in the public domain. Compassion scores in male students had a mean of 58.6 (range 22 to 78 and SD 9.2). Compassion scores in female students have a mean of 59.0 (range 29 to 80 and SD 9.1). Overall compassion scores were highest in MBBS students, both males and females when compared to Nursing and Physiotherapy students. Empathy scores also followed the same statistically significant pattern. Among compassion components, kindness was highest in BPT students while common humanity was higher in the medical students.MBBS students were seen to have significantly higher scores in all three negative components; indifference, separation and disengagement. It is proposed that the nature of training of nursing and physiotherapy students involves practical hands-on involvement in day to day care of their patients, while medical students are more involved in academic pursuits and less involvement with their patients during undergraduate training. Efforts must be made to encourage all healthcare students to inculcate empathy and compassion when communicating with patients. Empathy can be enhanced by adding training courses and workshops to the curriculum to teach empathy to develop interpersonal skills. There is a need to use innovative and creative approaches like simulation, role playing, storytelling and reflective discussion.