bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Neural Network Algorithms for Improved Performance: A
Computational Study
Authors: Ramaj Vehbi , Elezaj Rame , Čajić Elvir 
Published: January 2024

Abstract
Machine learning is an area of artificial intelligence that deals with the development of algorithms and models for automatically detecting patterns and making inferences from data. Neural networks are one of the most popular machine learning models that simulate the learning process of the brain and are widely used in various fields such as pattern recognition, prediction and control. Matlab is a popular programming language in the field of machine learning due to its ease of use and numerous libraries that contain the implementation of various machine learning algorithms.
In this paper, we will present the simulation of machine learning in neural networks using different algorithms in Matlab. We will describe several algorithms such as feedforward neural network, convolutional neural network and deep neural network. Also, we will show how these algorithms are applied in practice using different datasets. Finally, we will compare the performance of different algorithms and analyze their advantages and disadvantages.
Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma
Authors: Mao Xiaomin , Xu Shumin , Wang Huan , Xiao Peng , Li Shumin , Wu Jiaji , Sun Junhui , Cheng Jin , Shen Mo , Shi Yueli , Tang Bufu , Yang Ying , Chen Weiyu , Xu Zhiyong , Xu Yun 
Published: January 2024

Abstract
Cisplatin resistance remains a significant barrier in treating lung adenocarcinoma (LUAD). While the search for predictive biomarkers in LUAD prognosis has seldom focused on cisplatin resistance genes. In this study, we analyzed 181 cisplatin resistance genes from LUAD-related cell lines RNA sequences data using the TCGA and GEO databases, identifying two pivotal genes, E2F7 and FAM83A. Utilizing these genes, we established comprehensive models for diagnosis, prognosis, and recurrence risk in LUAD. Notably, our analysis revealed that the high-risk group, as defined by these models, displayed elevated levels of CD4 + T cells and CD8 + T cells, along with increased expression of PD-L1 and PD-L2, compared to their low-risk counterparts. Our in vitro studies demonstrated that inhibiting E2F7 in lung cancer cells significantly inhibited cell proliferation, decreased cell migration and invasion, while also increasing apoptosis rates. Corresponding in vivo experiments indicated that E2F7 knockdown suppressed tumor growth and lung metastasis in both subcutaneous tumor-bearing and tail-vein metastasis models. These findings underscore the diagnostic and prognostic efficacy of our E2F7 and FAM83A-based models, paving the way for more personalized treatment approaches in LUAD.
Applicability and Optimization of Viscous Dampers on Rc Frame Structure Against Seismic Loading
Authors: M Chandan , P Bhagyashri , K Chethan , Gopalaiah. Achutha Herur 
Published: January 2024

Abstract
In the present, the design and construction of high rise buildings against lateral loading are often equipped with suitable isolation techniques and use of dampers to terminate excess amount of responses in the building. The use of such techniques on the existing buildings is found to be effective in their performance. In this paper buildings of varying height with the different configurations based on the location and number of damper are modelled for the seismic analysis (response spectrum analysis). The results have shown that it is not only the number of dampers but also the position of dampers that contributes in the response reduction.
Emerging Factors Affecting Supply Chain Management of Horticulture Produce: A Systematic Literature Review
Authors: Kumar Vikas 
Published: January 2024

Abstract
Purpose
The management of supply chains for horticultural produce faces emerging factors that necessitate adaptation. This systematic literature review identifies and synthesizes key findings on the impacts of emerging technological, sustainability, consumer, climate, policy, cost, and competitive factors on the supply chain management of fruits, vegetables, and other horticulture products.
Design/methodology/approach
Searches of academic databases were conducted using defined keywords and selection criteria.
Findings
The findings indicate that blockchain, artificial intelligence, Internet of Things, automation, and other technologies can benefit traceability, quality control, and efficiency but require investment and skill development.
Research Implications
As per the finding, sustainability concerns like emissions, energy use, and waste are prompting supply chain innovation in production, packaging, transport, and distribution. Shifting consumer preferences toward local, organic, sustainable produce require flexibility and responsiveness. Climate change effects on agriculture production and globalization of markets are testing the resilience and agility of supply chains. Labor issues, rising input costs, and intense retail competition are squeezing profit margins across the fresh produce supply chain. Recommendations include investment in emerging technologies, collaboration for sustainability, data-driven supply chain optimization, and adaptable retail strategies.
Originality value
This review provides insights for researchers and supply chain managers seeking to improve the performance and competitiveness of horticultural produce supply chains.
Features of gynecological status and concomitant morbidity in menopausal women with resistant rheumatoid arthritis and obesity
Authors: Panevin T. S. , Matyanova E. V. , Ledina A. V. , Zotkin E. G. 
Published: January 2024

Oftentimes, women with RA experience remission during pregnancy. The beneficial effect of pregnancy on the RA course is associated with a specific hormonal status, including high levels of estriol and progesterone that have known anti-inflammatory effects. After childbirth, decreased endogenous production of steroids can trigger the onset or exacerbation of RA.Objective. Studying of the characteristics of the gynecological status and concomitant extragenital diseases in postmenopausal women with rheumatoid arthritis (RA) depending on the presence of obesity.Materials and methods. 394 postmenopausal women with RA (diagnosed according to ACR/EULAR 2010 criteria) were included. By decision of the medical commission, all patients were approved for therapy with genetically engineered biological drugs and/or JAK kinase inhibitors. Before inclusion in the study, all patients had a detailed medical history, an allergic history, registered comorbidities, and a physical and laboratory-instrumental examination. Depending on the BMI values, the study participants were divided into groups. Group A included 103 obese patients of any severity (BMI ≥ 30 kg/m2). Group B included 291 women with BMI <30 kg/m2. Patients with an inflammatory process were found to have groups of inflammation by age and duration of RA (p > 0.05).Results. In patients of group A, more often than in patients of group B, comorbidities were detected: hypertension (p < 0.0001), coronary heart disease (p = 0.03), history of “vascular accidents” (p = 0.0009), especially acute cerebrovascular accident (p = 0.004), type 2 diabetes mellitus (p = 0.0005), which manifest themselves over the age of 45, that is, during the perimenopause. When correcting the gynecological history data, he draws attention to the fact that group A patients are more likely to operate surgically and on the pelvic organs: more had the uterus removed (p = 0.002) or ovarian resection was performed (p < 0.0001), and the frequency of surgical menopause in group A was higher than in group B (p = 0.0009). The debut of RA on average chronologically coincided with the onset of menopause (p = 0.01). At the same time, in the average age of the onset of menopause, it is rare (p > 0.05). The number of women who had a history of pregnancy, childbirth, miscarriages and abortions in the groups were repeated (p > 0.05). But in group A, the average number of pregnancies (p = 0.003) and abortions (p = 0.004) per woman was higher than in group B.Conclusion. The results of the study revealed the identification of clinical manifestations of inflammation and the severity of rheumatoid arthritis, depending on the presence of concomitant obesity in postmenopausal women, as well as a rarer occurrence of osteoporosis in women with RA and concomitant obesity.
Changes in vaginal secretion lipidom as a result of therapy in patients with vulvovaginal atrophy
Authors: Kazakova S. N. , Tokareva A. O. , Novoselova A. V. , Chagovets V. V. , Apolikhina I. A. , Frankevich V. E. 
Published: January 2024

Introduction. Vulvovaginal atrophy is a chronic progressive disease that includes physiological and anatomical changes as a result of a decrease in the level of sex hormones. VVA affects approximately 50% of middle-aged and older women and has a detrimental effect on interpersonal relationships, sexual health, and overall quality of life. Dynamic quadripolar radiofrequency (DRF) is a non-invasive procedure that may be a potential treatment for vulvar diseases.Aim. To study the metabolites of vaginal swabs in postmenopausal women treated with DRF.Materials and methods. The study included 180 women divided into 3 groups: treatment with DRF; treatment with a combination of DRF and estradiol, and estradiol treatment. In all patients, vaginal swabs were taken before the start of treatment and a month after treatment, and clinical parameters were assessed at 6 time points. Lipids were extracted from the cervico-vaginal fluid by the Folch method followed by liquid chromatography-mass spectrometric analysis. A comparative analysis of the clinical data of each of the groups and lipid profiles after treatment with a zero time point and their changes and a correlation analysis of changes in lipid levels and changes in clinical parameters before treatment and after 1 month was carried out.Results. There was a statistically significant reduction in the severity of VVA symptoms one month after treatment in all groups. The most pronounced effect of the therapy was observed in groups with the use of DRF with the preservation of the effect up to 12 months. In the first and second groups, a statistically significant difference was found in the levels of 2 lipids, in the third – in 4. In the first group, a correlation was found with lipids related with pain and lubrication, in the second – with vaginal pH, in the third – with the index of vaginal health, orgasm, satisfaction and pain.Conclusions. VVA therapy by DRF and local hormonal treatment triggers an inflammatory cascade in tissues. The use of the strategy of treatment with physical methods of influence has a mechanism of influence similar to the local application of estrogen in VVA. DRF therapy leads to the normalization of the vaginal microbiota and can compete with the use of estrogen in this therapeutic effect.
Complex therapy of the evaporative form of dry eye syndrome in patients after keratorefractive surgery
Authors: Korneeva A. V. , Akhmedova L. I. , Kotova L. K. , Bagirov A. M. 
Published: January 2024

Introduction. Meibomian gland dysfunction (MGD) is considered as the leading cause of the evaporative dry eye syndrome (DES). At the same time the standard methods of DES treatment often allow to achieve only a short-term effect and the search of alternative methods to achieve remission for a longer period is required.Aim. To evaluate the effectiveness of a combined treatment of DES with MGD using transdermal Intense Pulsed Light (IPL) method combined with preservative-free sodium hyaluronate 0.18% eyedrops.Materials and methods. The study involved 60 patients (120 eyes) after refractive surgery (femtoLASIK) with DES and MGD aged 20 to 40 years with a follow-up period of 3 months. The patients were divided into two groups: main (30 patients) and control (30 patients). Patients of both groups were administered a preservative-free form of 0.18% sodium hyaluronate four times a day for 3 months. All studied patients underwent standard examination methods, indicators of DES were assessed along with an objective valuation of tear film parameters and the meibomian glands condition by mean of digital biomicroscopy using a MediWorks slit lamp before surgery and 7 days, 1, 2 and 3 months after refractive surgery.Results and discussion. A comparative analysis of therapy effectiveness in the main and control groups showed that OSDI scores (ocular surface disease index), non-invasive tear breakup time (NITBUT) and meibomian gland function improved after treatment in both groups, but in the main group (IPL) positive dynamics of indicators were more pronounced with a cumulative increase of effectiveness after subsequent sessions.Conclusion. A course of IPL therapy in combination with a course of sodium hyaluronate 0.18% for dry eye syndrome due to MGD reduces the time, allows for longer-term results of therapy and promotes earlier elimination of discomfort.
The effectiveness of the introduction of dietary therapeutic foods in the eradication of <i>Helicobacter pylori</i> in patients with chronic gastritis
Authors: Minushkin O. N. , Nikityuk D. B. , Pilat T. L. , Zverkov I. V. , Maslovskii L. V. , Evsikov А. E. , Kuznetsova Yu. G. , Inevatova V. S. , Klochkova S. V. 
Published: January 2024

Introduction. In recent years, a high resistance of H. pylori infection to antibiotics has been recorded both worldwide and in the Russian Federation. This was the basis for introducing diets that increase the sensitivity of H. pylori to antibiotics into eradication schemes.Aim. To evaluate the effect of specialized therapeutic nutrition products LEOVIT GASTRO on the eradication of H. pylori.Materials and methods. Two study groups were formed: the main group – 22 patients and the control group – 20 patients. The groups were randomized from 42 patients suffering from chronic gastritis associated with H. pylori, by random sampling. To assess the tolerability of treatment, in particular, biochemical blood tests were studied.Results. Therapeutic nutrition provides a significant eradication effect against the background of antibiotic therapy. In 92% of patients, a complete absence of H. pylori contamination was detected, and in 8% of patients the degree of contamination was very weak, although initially it was pronounced, while in the control group, a complete absence of H. pylori contamination was detected in 80% of patients. Analysis of the use of specialized food products indicates the possibility of their use in diseases of the gastrointestinal tract associated with H. pylori, as they promote epithelization, healing of the mucosa, reduction and elimination of inflammation, pain, and discomfort in the gastrointestinal tract.Conclusion. Therapeutic dietary nutrition LEOVIT GASTRO is one of the important factors positively influencing the success rate of eradication treatment.
Analysis of the temporal variations in glaciers’ surface area in Alaknanda River Basin, Uttarakhand
Authors: Nunchhani V. , Hazarika Sujit , Murtem Rimum , Bandyopadhyay Arnab , Bhadra Aditi 
Published: January 2024

Abstract

This study presented detailed analysis of glacier surface extent in the Alaknanda river basin, Western Himalaya, using Landsat series data, land surface temperature and digital elevation model (DEM). The clean glaciers were delineated using automatic glacier extraction index (AGEI) and the debris-covered glaciers were extracted by utilizing slope and land surface temperature. The generated glaciers map was compared and cross-checked with Randolph Glacier Inventory (RGI v5.0) and sharp google earth image. The reduction in glacier surface area was observed by 367.364 sq. km from 1994 (1150.471 sq. km) to 2015 (783.107 sq. km) at the shrinkage rate of 1.45% per annum. The shrinkage rate was higher from 2006 to 2015 (2.43% per annum) than from 1994 to 2006 (0.78% per annum). The glacier count expanded from 314 (1994) to 360 (2015) due to the fragmentation of individual glaciers. The elevation range of 5000–5500 m above m.s.l. hosted maximum number of glaciers and glacial coverage. The debris-covered glaciers showed deglaciation at the rate of 0.59% per annum from 1994 to 2015. The total area occupied by glacier extent was about 25% of the total basin in the year 1994, 23% in the year 2006 and 17% in the year 2015.
Pilot clinical trial of DNA vaccination against neuroblastoma: study design and preliminary results
Authors: Proleskovskaya I. V. , Meleshko A. N. , Vashkevich E. P. , Konoplya N. E. 
Published: January 2024

Introduction. We report preliminary results of a pilot clinical trial of therapeutic DNA vaccination of patients with neuroblastoma (NCT04049864).The aim of the study – is to test the safety and immunogenicity of DNA vaccination against neuroblastoma.Materials and methods. The results of 6 patients who completed vaccination are summarized in the article. Inclusion and exclusion criteria for patients are defined. The clinical protocol included vaccine form and doses, timed vaccination regimen, and concomitant therapy. Minimal residual disease was analyzed for all patients by quantitative polymerase chain reaction, measurement of T-cell immune response by ELISpot and antisense response by ELISA.Results. The vaccine was well tolerated by patients with minimal adverse symptoms. T-cell immune response was evaluated two weeks after each course of vaccination and was positive in 5 of 6 patients. An antisense immune response was detected in 1 patient. 5 out of 6 patients are alive and in clinical remission as of 11/01/2022. Event-free survival of vaccinated patients was 82 ± 18 % vs 29 ± 11 % of controls (p = 0.03).
The relevance of genetic testing in young patients with breast fibroadenomas
Authors: Mikhailova S. N. , Semenova V. V. , Nasedkina T. V. , Valiev T. T. , Khestanov D. B. , Varfolomeeva S. R. 
Published: January 2024

Introduction. Fibroadenomas are the most common benign tumors of the mammary glands in children and adolescents. In some cases, they may be part of hereditary tumor predisposition syndromes associated with a high risk of developing malignant neoplasms throughout life, and therefore genetic testing is relevant.The purpose of the study is to discribe the spectrum of genetic mutations in cancer-associated genes according to the results of next generation sequencing (NGS) in young patients with breast fibroadenomas.Matherials and methods. Sixteen teenage girls with fibroadenomas of the breast who were followed up in Research Institute of Pediatric Oncology and Hematology from 2020 to 2023 were enrolled in this study. Genetic testing by NGS was performed.Results. Pathogenic variants in cancer-associated genes were found in 4 (25 %) patients. In two cases, fibroadenomas were a part of Cowden’s syndrome associated with PTEN inactivation; two patients carried pathogenic variants in the BRCA1 and BRCA2 genes.Conclusion. Genetic testing of young patients with breast fibroadenomas is important to optimize the management strategy in order to reduce cancer risk in high-risk groups of patients.
Autophagy Inhibition and Sensitization to Cisplatin in Esophageal
Cancer Stem-Like Cells via All-trans Retinoic Acid-induced miR-30a
Authors: Abbasi Asadollah , Hosseinpourfeizi Mohammadali , Safaralizadeh Reza 
Published: January 2024

Aim:
Providing insights into the chemoresistance of esophageal squamous
cell carcinoma (ESCC) and its dependence on chemotherapy-induced autophagy.

Background:
Autophagy is induced during chemotherapy of cancer cells, promoting resistance
to anti-cancer treatments.

Objective:
The objective of this study is to investigate the modulation of microRNA-30a
(miR-30a), a known regulator of autophagy, in ESCC cells by all-trans retinoic acid (ATRA).

Methods:
Treatment involved ESCC cells KYSE-30 and TE8 with cis-dichloro-diamine
platinum (CDDP), enriching CDDP-surviving cells (CDDP-SCs). qRT-PCR and dual luciferase
reporter assay (DLRA) were employed to evaluate miR-30a expression and its
interaction with Beclin-1 (BECN1) in both CDDP-SCs and those treated with ATRA.

Results:
Chemotherapy using CDDP led to a significant decrease in miR-30a expression
within ESCC cells. Increased autophagy levels were identified in cancer cells exhibiting
stem cell-like properties, characterized by the overexpression of specific stem cell markers.
These results suggest that the downregulation of miR-30a induced by CDDP treatment
may represent a potential underlying mechanism for increased autophagic activity,
as evidenced by the upregulation of autophagy-related proteins, such as BECN1 and an
elevated LC3-II/LC3-I ratio. ATRA treatment elevated miR-30a expression and disrupted
hallmark cancer stem cell (CSC) features in ESCC cells. Further investigations demonstrated
that increased miR-30a expression led to a reduction in the expression of its
target gene, BECN1, and attenuated BECN1-mediated autophagy. This resulted in an
augmentation of CDDP-induced apoptosis in ESCC cells and a G2/M cell cycle arrest.

Conclusion:
CDDP chemotherapy reduced miR-30a, promoting ESCC cell resistance
through autophagy and CSC-like features, a process that may be modulated by ATRA.
Konsep Sustainable Design Pada Interior Loma Kafe Prambanan
Authors: Bitutomo Martinus , Ambarwati Dwi Retno Sri 
Published: January 2024

Penelitian ini memiliki tujuan yaitu untuk merancang sebuah kafe yang memiliki konsep Sustainable Design. Penerapan konsep Sustainable Design pada perancangan Loma Kafe Prambanan ini dilakukan dalam rangka penyelamatan bumi. Hasil penelitian penerapan konsep Sustainable Design pada perancangan interior meliputi 1) Penerapan konsep Sustainable Design, meliputi: pemilihan dan penerapan material yang bersifat alam dan renewable, pemaksimalan penggunaan dan penerapan sistem pencahayaan alami dan penghawaan alami sebagai langkah penghematan energi, menggunakan finishing yang bersifat durable dan ramah lingkungan pada semua elemen interior pada perancangan Loma Kafe Prambanan. 2) Penerapan konsep Sustainable Design pada perancangan interior Loma Kafe Prambanan tidak mengalami perubahan setelah dilakukan validasi desain oleh ahli desain dan pemilik Loma Kafe Prambanan karena sudah memenuhi kriteria sebagai bangunan kafe yang menerapkan konsep Sustainable Design dan dinyatakan layak. 3) Hasil perancangan desain berupa gambar kerja 2 dimensi, gambar perspektif 3 dimensi, serta video presentasi.
Multimedia pembelajaran prakarya kerajinan serat alam berbasis Website Glide App
Authors: Nurrohma Isti , Martono Martono 
Published: January 2024

Dalam pelaksanaan pembelajaran masih ditemukan faktor media belajar yang kurang mendukung. Karena itu penelitian bertujuan untuk: (1) mengembangkan materi, (2) mengembangkan multimedia pembelajaran menggunakan Website Glide App untuk mengikuti perkembangan transformasi digital, (3) mendeskripsikan penerapan multimedia Website Glide App. Serta (4) mendeskripsikan kelayakan multimedia Website Glide App. Metode penelitian yang digunakan adalah Research and development (RD) dengan model pengembangan ADDIE. Penelitian dilakukan di SMP Negeri 32 Purworejo. Pengumpulan data dilakukan menggunakan metode observasi dan angket. Hasil penelitian menunjukkan: (1)Materi Prakarya Kerajinan bebasis Website Glide App dikembangkan melalui 5 tahap yaitu a) Analisis; b)Desain; c)Development; d)Impementasi; e)Evaluasi. (2) Multimedia Pembelajaran Website Glide App layak digunakan berdasarkan penilaian dari a) Ahli materi, b) Ahli media, c) Praktisi Pembelajaran dengan rata-rata hasil kelayakan adalah 91,53% (Sangat Layak) (3) Hasil penilaian siswa terhadap media pada ujicoba perorangan 88,3% (Sangat Layak), uji coba kelompok kecil 96,1% (Sangat Layak) dan ujicoba lapangan 91,4% (Sangat Layak). Berdasarkan analisis peningkatan hasil pretest dan posttest dengan menggunakan gain score, Media Pembelajaran Website Glide App efektif digunakan.