bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attributions of emission-reduction and meteorological conditions to typical heavy pollution episodes in a cold metropolis, northeast China
Authors: Li Junfei , Sun Li , Yao Xin , Zang Shuying , Wang Jiao , Ma Dalong 
Published: December 2023

Heavy pollution episodes frequently occurred in winter in northeast China due to the multiple anthropogenic emissions coupled with adverse meteorological conditions, which increased the difficulty of environmental pollution control. To better enact strategies for mitigating air pollution in the post-pandemic era, daily pollutant concentration monitoring and meteorological data were used to evaluate the changes and meteorological factors of air pollutants before (2019) and during (2020) the lockdown in Harbin City, northeast China. Moreover, typical pollution episodes under COVID-19 lockdown were identified, and their emission sources, meteorology conditions, and regional pollution transportation were analyzed. The results showed significant decreases in NO2, PM10 and CO, while O3 increased, and no differences in PM2.5 and SO2 during the lockdown compared with non-lockdown periods. It indicated that reduced activities of transportation resulted in reductions of NO2 concentrations by 16%, and stationary emission sources were less affected. Correlation between PM2.5 and O3 tended to change from positive to negative as the threshold of PM2.5 = 90 μg m−3, with the main controlling factor changed from their common gaseous precursors to meteorological conditions (temperature &lt;0°C and wind speed &lt;2 m s−1). Pollution days were concentrated in the COVID-19 lockdown period with PM2.5 as the primary pollutant. SO2 dominant pollution and PM2.5 dominant pollution were distinguished from six sustained heavy pollution events. PM2.5 and SO2 played essential roles in SO2 dominant pollution, which derived from local emissions of coal combustion and firework discharge. PM2.5 dominant pollution might be chemical transformed from coal burning, vehicle exhaust, and other secondary precursors, which was affected and aggravated by CO, NO2, high relative humidity and low wind speed affected by local emission and long-distance transport.
Association between glycemic traits and melanoma: a mendelian randomization analysis
Authors: Zhang Yun-Chao , Lu Cen-Di , Li Quan-Yao , Shi Jin-Na , Shi Jun , Yang Min 
Published: December 2023

Background: The causation of Glycemic Traits and risks of Melanoma remains unknown. We used Mendelian Randomization (MR) to assess the links between Glycemic Traits and Melanoma.Method: Pooled data from Genome-Wide Association Studies (GWAS) were utilized to examine the relationships that exist between Fasting Insulin (n = 26), 2-h Glucose (n = 10), Fasting Glucose (n = 47), HbA1c (n = 68), and Type-2 Diabetes (n = 105) and Melanoma. We evaluated the correlation of these variations with melanoma risk using Two-Samples MR.Result: In the IVW model, Fasting Glucose (OR = 0.99, 95%CI = 0.993–0.998, p &lt; 0.05, IVW), Type-2 Diabetes (OR = 0.998, 95%CI = 0.998–0.999, p &lt; 0.01, IVW) and HbA1c (OR = 0.19, 95%CI = 0.0415–0.8788, p &lt; 0.05, IVW) was causally associated with a lower risk of Melanoma. In all models analyzed, there was no apparent causal relationship between Fasting Insulin and Melanoma risk. There was no obvious causal difference in the IVW analysis of 2-h Glucose and Melanoma, but its p &lt; 0.05 in MR Egger (OR = 0.99, 95%CI = 0.9883–0.9984, p &lt; 0.05, MR Egger), and the direction was consistent in other MR analyses, suggesting that there may be a causal relationship.Conclusion: The results of this study suggest that a higher risk of Fasting Glucose, Type-2 Diabetes, 2-h Glucose, and HbA1c may be associated with a lower risk of Melanoma. However, no causal relationship between fasting insulin and melanoma was found. These results suggest that pharmacological or lifestyle interventions that regulate plasma glucose levels in the body may be beneficial in the prevention of melanoma.
Menstruation-related symptoms are associated with physical activity and midpoint of sleep: a pilot study
Authors: Masuda Hazuki , Okada Shima 
Published: December 2023

IntroductionMenstruation-related symptoms (MRSs) significantly impact women's health and contribute to economic burdens worldwide. Current interventions, primarily pharmacological ones, have limitations and side effects that underscore the need for alternative management strategies. This study explores the association between MRSs and lifestyle factors, specifically physical activity and sleep timing across menstrual cycle phases, to inform non-pharmacological intervention development.MethodsFourteen female students from Ritsumeikan University, Japan, with regular menstrual cycles (25–38 days), not on hormonal treatment or engaged in shift work, participated in this observational study. Using a Fitbit Inspire 2, total daily energy expenditure (TDEE) and sleep timing were monitored over a complete cycle. Menstrual cycle phases were defined based on ovulation day, predicted using home luteinizing hormone tests. Participants completed daily electronic questionnaires rating MRSs using a modified menstrual distress questionnaire. Data were analyzed using a generalized linear mixed model with a gamma distribution and logarithmic link function, examining the relationship of TDEE and the midpoint of sleep time (MS time) with MRS severity.Results and discussionThe following observations were noted: first, MRS severity, except for behavioral change symptoms, significantly increased during the menstrual and luteal phases compared to the follicular phase. Second, delayed MS time was associated with reduced pain, concentration symptoms, water retention, and negative affect during the menstrual phase and reduced negative affect during the luteal phase. Finally, an increase in TDEE was associated with reduced concentration symptoms, autonomic reaction symptoms, and negative affect during the menstrual and luteal phases and reduced water retention only during the luteal phase. This study provides insights into the relationship between MRSs and TDEE/MS time, suggesting potential non-therapeutic approaches for symptom management, though further research is needed to substantiate these findings for practical applications.
Evaluation of the humoral and mucosal immune response of a multiepitope vaccine against COVID-19 in pigs
Authors: Mosqueda Juan , Hernández-Silva Diego Josimar , Vega-López Marco Antonio , Vega-Rojas Lineth J. , Beltrán Rolando , Velasco-Elizondo Andrés , Ramírez-Estudillo María del Carmen , Fragoso-Saavedra Mario , Pérez-Almeida Chyntia , Hernández Jesús , Melgoza-González Edgar A. , Hinojosa-Trujillo Diana , Mercado-Uriostegui Miguel Ángel , Mejía-López Alma Susana , Rivera-Ballesteros Carlos , García-Gasca Teresa 
Published: December 2023

IntroductionThis study evaluated the immune response to a multiepitope recombinant chimeric protein (CHIVAX) containing B- and T-cell epitopes of the SARS-CoV-2 spike’s receptor binding domain (RBD) in a translational porcine model for pre-clinical studies.MethodsWe generated a multiepitope recombinant protein engineered to include six coding conserved epitopes from the RBD domain of the SARS-CoV-2 S protein. Pigs were divided into groups and immunized with different doses of the protein, with serum samples collected over time to determine antibody responses by indirect ELISA and antibody titration. Peptide recognition was also analyzed by Western blotting. A surrogate neutralization assay with recombinant ACE2 and RBDs was performed. Intranasal doses of the immunogen were also prepared and tested on Vietnamese minipigs.ResultsWhen the immunogen was administered subcutaneously, it induced specific IgG antibodies in pigs, and higher doses correlated with higher antibody levels. Antibodies from immunized pigs recognized individual peptides in the multiepitope vaccine and inhibited RBD-ACE2 binding for five variants of concern (VOC). Comparative antigen delivery methods showed that both, subcutaneous and combined subcutaneous/intranasal approaches, induced specific IgG and IgA antibodies, with the subcutaneous approach having superior neutralizing activity. CHIVAX elicited systemic immunity, evidenced by specific IgG antibodies in the serum, and local mucosal immunity, indicated by IgA antibodies in saliva, nasal, and bronchoalveolar lavage secretions. Importantly, these antibodies demonstrated neutralizing activity against SARS-CoV-2 in vitro.DiscussionThe elicited antibodies recognized individual epitopes on the chimeric protein and demonstrated the capacity to block RBD-ACE2 binding of the ancestral SARS-CoV-2 strain and four VOCs. The findings provide proof of concept for using multiepitope recombinant antigens and a combined immunization protocol to induce a neutralizing immune response against SARS-CoV-2 in the pig translational model for preclinical studies.
Screening and validation of double allele-specific binding F-primers for the measurement of antihypertensive pharmacogenomics
Authors: Ping Yang , Quanlin Su , Yue Hu , Jing Zhang , Wenjun Lan 
Published: December 2023

ObjectivePrevious studies have proposed that genetic polymorphisms of CYP2D6*10, ADRB1, NPPA, CYP3A5*3, ACE, CYP2C9*3, and AGTR1 are involved in antihypertensive pharmacogenomics. The purpose of this study is to develop an amplification analysis using double allele-specific (AS) binding primers for accurate measurement of antihypertensive pharmacogenomics.MethodsTo establish a quadruplex quantitative PCR (qPCR) analysis for genotyping of CYP2D6*10, ADRB1 (1165 G&gt;C), NPPA (2238 T&gt;C) and CYP3A5*3, and a triplex qPCR analysis for genotyping of ACE (I/D), CYP2C9*3 and AGTR1 (1166 A&gt;C), mismatch AS F-primers were screened by detection of plasmid/gDNA, and were validated by agreement analysis/reproducibility evaluation, in which the ΔCq (differences in threshold cycles between the wild-type F-primer-based amplification assay and the mutant-type F-primer-based amplification assay) was employed to determine genotypes.ResultsSeven pairs of primers were successfully selected through three rounds of F-primers screening. Except for ADRB1, the robustness assessment showed the amplification efficiency ranging from 0.9 to 1.1. In agreement analysis, two specimens in the training set (n = 203) were defined by the triplex analysis rather than NGS as heterozygotes for ACE, which was evidenced by gel electrophoresis. Reproducibility evaluation demonstrated that the coefficient of variation (CV) was &lt;5%.ConclusionMultiplex amplification analysis using screened AS binding primers is a simple, reliable, and accurate tool to guide drug delivery in antihypertensive personalized treatment.
Personality traits and Chinese college students’ satisfaction with physical education classes: the mediating role of trait fluency and the moderating role of physical education class difficulty
Authors: Chen Zhiduo , Tian Yuge , Li Min , Yang Shangjian 
Published: December 2023

BackgroundThis study aims to investigate the impact mechanism of personality traits on physical education satisfaction among college students, validating the mediating effect of trait flow and the moderating effect of physical education difficulty. By analyzing the influence mechanism of personality traits on college students’ satisfaction with physical education classes, it helps to explore more channels to enhance satisfaction with physical education classes.MethodsA questionnaire survey was conducted using the Big Five Personality Scale, the Physical Education Class Satisfaction Scale, the Trait Fluency Scale, and the Physical Education Class Difficulty Scale with 868 public physical education students in 10 universities in Shanghai. Moderated mediation modeling was conducted using Hayes’ PROCESS macro.ResultsPersonality traits are positively correlated with physical education satisfaction, and the predictive effect is significant (β = 0.786, p &lt; 0.001). This association is mediated by trait fluency (indirect effect: β = 0.797, p &lt; 0.001), accounting for 62.7% of the total effect. Physical education difficulty significantly moderates the predictive effects of personality traits on physical education satisfaction (β = −0.183, p &lt; 0.01) and trait fluency (β = −0.130, p &lt; 0.001). Additionally, physical education difficulty significantly moderates the predictive effect of trait fluency on physical education satisfaction (β = 0.172, p &lt; 0.001).ConclusionPersonality traits predict physical education satisfaction, with trait fluency playing a mediating role, and physical education difficulty moderates the direct and indirect paths through which personality traits influence physical education satisfaction.
High psychological stress levels related to delivery can increase the occurrence of postpartum mental disorders
Authors: Sun Ruixue , Zhao Mingzhe , Ma Liangkun , Duan Yanping , Wei Jing 
Published: December 2023

ObjectiveThe study sought to explore the relationship between high psychological stress levels related to delivery and postpartum mental disorders.MethodsA total of 284 parturients were included in the study from July 2021 to January 2022. The stress level at 1 month postpartum was assessed by the Impact of Event Scale-Revised (IES-R). Parturients with an IES-R score ≤ 9 were included in the low psychological stress level group, and those with an IES-R score &gt; 9 were included in the high psychological stress level group. The Edinburgh Postnatal Depression Scale (EPDS), Union Physio-Psycho-Social Assessment Questionnaire (UPPSAQ-70), Symptom Checklist-90 (SCL-90) and Mini-International Neuropsychiatric Interview (M.I.N.I.) were conducted at 42 ± 7 days postpartum to assess the mental health of parturients.The parturients’ mental health after birth was assessed by the EPDS, UPPSAQ-70, and SCL-90. Semi-structured diagnostic interviews were conducted at 42 ± 7 days postpartum by using the M.I.N.I.ResultsThe incidence rate of postpartum mental disorders was 20.42% (58/284), the incidence rates of postpartum depression, anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder were 17.96% (51/284), 11.97% (34/284), 4.58% (13/284) and 1.41% (4/284), respectively, and the comorbidity rate was 58.62% (34/58). A history of mental disorders and pregnancy complications were risk factors for postpartum depression (p = 0.028, p = 0.040, respectively); a history of mental disorders, a lack of physical exercise, partner violence and pregnancy complications were risk factors for postpartum anxiety disorders (p = 0.003, p = 0.007, p = 0.031, p = 0.048, respectively); and the delivery of female infants was a risk factor for postpartum obsessive-compulsive disorder (p = 0.022).The risk of postpartum depression, anxiety disorders and obsessive-compulsive disorder was 9.125 times (95% CI = 3.900 ~ 21.349, p &lt; 0.01), 7.310 times (95% CI = 2.588 ~ 20.649, p &lt; 0.01) and 6.259 times (95% CI = 1.347 ~ 29.093, p &lt; 0.01) higher in postpartum women with high psychological stress levels related to delivery than in those with low psychological stress levels, respectively.ConclusionThe incidence of postpartum mental disorders is high and has a positive correlation with the level of psychological stress. This may lead to a new perspective of the effect of psychological stress on postpartum mental disorders and attract more attention to other mental disorders in addition to postpartum depression.
Personality traits and the degree of work addiction among Polish women: the mediating role of depressiveness
Authors: Rachubińska Kamila , Cybulska Anna Maria , Kupcewicz Ewa , Panczyk Mariusz , Grochans Szymon , Walaszek Ireneusz , Grochans Elżbieta 
Published: December 2023

ObjectivesWorkaholism is an addiction, however the obsessive-compulsive components alone may prove insufficient in determining its nature. The aim of the following study was to determine the mediating role of depressiveness in the relationships between workaholism and personality traits according to the five-factor model among Polish women.MethodsThe research study was carried out among 556 women residing in the West Pomerania Voivodeship in Poland. The research was based on a survey performed using a questionnaire technique. The following research instruments adapted to Polish conditions were employed to assess the incidence of work addiction among female adults: The NEO Five-Factor Inventory (NEO-FFI), The Work Addiction Risk Test (WART) Questionnaire, and The Beck Depression Inventory–BDI I-II.ResultsA positive correlation between the intensity of neuroticism and the work addiction risk was revealed (β = 0.204, p &lt; 0.001). A partial mediation (35%) with the severity of depression symptoms as a mediating factor was observed (β = 0.110, p &lt; 0.001). Respondents characterized by high neuroticism showed a greater severity of the symptoms of depression (β = 0.482, p &lt; 0.001), which is a factor increasing the work addiction risk (β = 0.228, p &lt; 0.001). No effect of extraversion intensity on the work addiction risk was found (β = 0.068, p = 0.081). Respondents characterized by a high level of extraversion displayed lower severity of the symptoms of depression (β = −0.274, p &lt; 0.001). A negative correlation between the intensity of agreeableness and the work addiction risk was revealed (β = −0.147, p &lt; 0.001). A partial mediation (27.8%) was observed. A positive correlation between the intensity of conscientiousness and the work addiction risk was revealed (β = 0.082, p = 0.047). Respondents characterized by a high level of conscientiousness showed a lower severity of depression symptoms (β = −0.211, p &lt; 0.001).ConclusionDepressiveness plays the role of a mediator between neuroticism, extraversion, agreeableness as well as conscientiousness, and work addiction. Depressiveness is a factor which increases the risk of work addiction.
CONTENT OF VASYL LOBURETS’ SCIENTIFIC AND PEDAGOGICAL ACTIVITY
Authors: Yermolenko O. 
Published: December 2023

The article highlights the content of the scientific and pedagogical activities of the famous scientist-pedagogue, historian, local historian, and organizer of scientific work V. Loburеts. It is proved that the main feature of the V. Loburеts’ scientific and pedagogical activity was the harmonious integration of research and educational aspects. Based on the study of biographical, narrative literature, and archival materials, the main components are analyzed. They are the following: the development of the methodology of scientific and educational cognition (V. Loburets revealed the main principles of rational cognition of reality: objectivity in cognition, acceptance of the dominant role of practice in the process of cognition, holistic perception of science and the educational course, a harmonious combination of theoretical and practical aspects of cognition, the importance of the creative activity of the individual in cognition); improvement of the content, methods, and forms of teaching historical disciplines (V. Loburets improved the theoretical content of historical disciplines, which was based on the principles of scientific and cultural relevance, logical consistency, systematicity, integration of theory with practice, historicism, and the usage of the educational potential of academic disciplines); improvement of lecturing skills (V. Loburts’s lectures were characterized by scientific conceptuality, rational selection of material, logic and consistency, accuracy and flexibility of statements, optimal use of scientific terms, presentation of information that guides students’ self-study, and practical value for future activities at school). It has been determined that V. Loburets’s scientific and pedagogical activity had a general pedagogical and practice-oriented focus on the implementation of future teacher training.
THE CONCEPT OF UPDATING THE CONTENT OF FUTURE LECTURERS OF PEDAGOGICAL UNIVERSITIES TRAINING IN TERMS OF THE SOCIAL NEEDS DURING WAR AND POST-WAR TIMES
Authors: Kucheriavyi O. 
Published: December 2023

The article defines and reveals the structural elements of the concept of updating the content of professional training of future lecturers of pedagogical higher education institutions in terms of the social needs during the war and post-war period. Conceptual ideas are revealed. They are the following: 1) the need to ensure anticipatory and culturally relevant nature of the content of education, to achieve functional completeness; 2) updating the content at the intersection of the post-war needs of society in revival and cultural creation and the teacher’s needs in personal and professional development; 3) transforming the content into a carrier of the dominant values of national culture, national spirit with the priority status of the Ukrainian language; 4) choosing a strategic line for professional, psycho-pedagogical and digital fundamentalization of the content; 5) taking into account in the content of education the needs of the personality of the future teacher in holistic development throughout life; 6) expansion of the functional range of the content due to the inclusion of the valeological-psycho-pedagogical function in unity with the activity-activating one; 7) enrichment of the content with the achievements of world scientific psychological and pedagogical innovations.
The essence of the system of the teacher’s professional and digital competencies as a target guideline for updating the content of their professional training in the conditions of martial law in the country has been determined. The following principles of actual renewal of the content of the professional education of future teachers of pedagogical higher education institutions are characterized. They are the following: 1) value-content restructuring of mixed and online preparation of students for professional activities at the intersection of the needs of Ukraine in post-war revival and cultural creation and the needs of future teachers in the holistic development and quality performance of professional and civic functions; 2) cultivation of strategic lines of renewal of the content of future teachers’ pedagogical education in the context of its professional, psycho-pedagogical and digital fundamentalization in harmonious unity; 3) the dominance of the culturally dominant Ukrainian-centric direction of updating the content of professional future teacher training using digital technologies; 4) laying the value-content foundation of the reference image of the teacher-master of the pedagogical higher educational institution of the future in accordance with the requirements of Ukraine’s European progress; 5) integration in the content of future teachers’ education of humanitarian, socio-cultural, professional-subject and professional-psycho-pedagogical, valeological (prior to achieving mental health) and safety knowledge.