bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH WAKTU AKTIVASI MEKANOKIMIA DAN KONSENTRASI NAOH TERHADAP KADAR AIR DAN KADAR ABU PADA ADSORBEN ZEOLIT
Authors: Mufidah Azizah Amelia , Takwanto Anang 
Published: September 2023

Zeolit merupakan kristal aluminosilikat yang mempunyai struktur pori yang teratur dan memiliki luas permukaan tinggi. Adsorben zeolit akan diaktivasi dengan metode mekanokimia dengan tujuan untuk menghilangkan pengotor-pengotor yang ada pada zeolit sehingga kemampuan adsorpsi nya bertambah. Mekanokimia merupakan proses pemanfaatan energi mekanik untuk merubah struktur bahan sehingga bahan yang dihasilkan memiliki luas permukaan yang lebih besar dan juga memiliki kemampuan mengadsorp dengan baik. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh waktu mekanokimia dan konsentrasi Natrium Hidroksida (NaOH) terhadap kualitas adsorben zeolit. Penelitian ini menggunakan metode kuantitatif dengan variabel tetap perbandingan zeolit dengan NaOH 1:4 (b/v) dan variabel berubah waktu mekanokimia 30; 60 menit dan konsentrasi NaOH 1; 2; 3 M. Analisis yang dilakukan pada pengujian adsorben zeolit adalah kadar air dan kadar abu. Hasil terbaik yang diperoleh dari kedua pengujian tersebut adalah kadar air sebesar 0,5% dan kadar abu sebesar 1,941%. Hasil tersebut menunjukkan bahwa adsorben zeolit memiliki kualitas yang baik.
PENGARUH PENAMBAHAN CHELATING AGENTS (ASAM ASKORBAT, HIDROKSILAMINA, DAN ASAM OKSALAT) DALAM FENTON-LIKE REACTION PADA PROSES DEGRADASI METILEN BIRU
Authors: Zulfani Mochamad Reza , Dewajani Heny 
Published: September 2023

Perkembangan industri tekstil di Indonesia menyebabkan semakin meningkatnya limbah pewarna yang dihasilkan. Salah satu upaya yang dilakukan dalam penanganan limbah pewarna tekstil jenis metilen biru adalah Fenton-Like Reaction. Proses ini dapat mendegradasi zat pewarna organik dengan baik, namun memiliki kekurangan berupa kondisi reaksi yang asam dan dihasilkannya presipitasi ion besi pada saat reaksi. Permasalahan tersebut dapat diatasi melalui penambahan chelating agents pada saat reaksi yang dapat mencegah terjadinya presipitasi ion besi dan meningkatkan kemampuan FePO4 dalam mengkatalis reaksi sehingga reaksi menjadi lebih cepat. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan chelating agents berupa asam askorbat (AA), hidroksilamina (HA), dan asam oksalat (AO) pada Fenton-Like Reaction untuk mendegradasi pewarna metilen biru dengan reaktan H2O2 dan katalis FePO4. Chelating agents yang memiliki kemampuan tertinggi dalam mendegradasi metilen biru selanjutnya diteliti pada konsentrasi terbaiknya dengan variasi 0,5; 1; 1,5 dan 2 mmol/L serta variasi pH awal reaksi 3, 5, 7 dan tanpa pengaturan pH awal. Hasil penelitian menunjukkan asam askorbat (AA) merupakan chelating agents dengan kemampuan mendegradasi metilen biru tertinggi dengan tingkat degradasi sebesar 99% setelah 1 jam reaksi. Konsentrasi asam askorbat (AA) terbaik dalam reaksi ini adalah sebesar 1 mmol/L dengan pH awal reaksi 3. Selain itu, penelitian ini juga menunjukkan bahwa dengan penambahan chelating agents, proses Fenton-Like Reaction dapat dilakukan pada pH yang asam dan juga pada pH netral.
STUDI KELAYAKAN PEMANFAATAN LIMBAH (BLOTONG, AMPAS TEBU, TETES) SEBAGAI BIOBRIKET
Authors: Firmansyah Ahmad Haris , Zamrudy Windi , Naryono Eko 
Published: September 2023

Peningkatan produksi gula di Indonesia sebanding dengan limbah yang dihasilkan, salah satunya adalah limbah blotong. Limbah jenis ini menyebabkan pencemaran lingkungan dan menimbulkan bau menyengat yang menganggu masyarakat sekitar sehingga perlu diolah lebih lanjut. Pemanfaatan limbah blotong dipadukan dengan ampas tebu dan tetes sebagai biobriket diharapkan dapat menjadi solusi penanganan limbah industri dan untuk pencarian energi alternatif. Penelitian ini bertujuan untuk mengetahui perbandingan variasi arang blotong dan ampas tebu terbaik dalam pembuatan biobriket limbah produksi gula dan mengetahui kelayakan biobriket dari blotong tebu ditinjau dari aspek ekonomi dan sosial. Pembuatan biobriket dilakukan dengan metode kuantitatif eksperimental diawali dengan pengeringan, dilanjutkan dengan karbonisasi dan pembriketan. Pembuatan biobriket dilakukan dengan variasi perbandingan bahan baku arang blotong dan ampas tebu sebesar 100:0, 95:5, 90:10, 85:15, 80:20. Hasil terbaik biobriket diperoleh pada variasi perbandingan blotong dan ampas tebu (90:10) yang menghasilkan kadar air briket 4,35%, laju pembakaran 0,107 g/menit dan nilai kalor 3.2520 kal/g. Analisis ekonomi yang telah dilakukan menunjukkan adanya prospek ekspor yang cukup besar diberbagai negara. Selain itu, produksi biobriket ini diproyeksikan menghasilkan laba bersih sebesar Rp 1.676.372.932,60 dan titik impas sebesar 75% dengan waktu pengembalian modal selama 2,1 tahun. Analisis aspek sosial lingkungan menunjukkan adanya peningkatan mutu hidup dan penyerapan tenaga kerja untuk masyarakat sekitar. Studi yang telah dilakukan menunjukkan bahwa bisnis biobriket berbahan baku blotong dan ampas tebu layak dilakukan jika ditinjau dari segi ekonomi dan sosial.
PRODUKSI LIPJAR (LIP BALM PARIJOTO) UNTUK PEMBERDAYAAN EKONOMI KELOMPOK NASYIATUL AISYIYAH KECAMATAN KOTA KABUPATEN KUDUS
Authors: Maulida Iffana Dani , Mundriyastutik Yayuk 
Published: September 2023

Lip balm merupakan kosmetik yang sudah populer terutama di kalangan wanita bermanfaat untuk melembabkan bibir. Pewarna yang digunakan di dalamnya pada umumnya adalah zat warna sintetis yang dapat menimbulkan sejumlah efek samping dan masih sedikit yang memanfaatkan zat warna alami yang lebih ramah kebermanfaatannya. Zat warna alami dari Parijoto yang sangat terkenal sebagai buah khas Kudus selama ini potensinya belum tergali maksimal. Inovasi dalam kegiatan ini yaitu penggunaan zat warna alami Parijoto untuk pewarna lip balm. Tujuan kegiatan pengabdian kepada masyarakat ini adalah pemberdayaan ekonomi masyarakat mitra yaitu kelompok Nasyiatul Aisyiyah kecamatan Kota Kabupaten Kudus dengan pembekalan pengetahuan dan keterampilan kepada mitra serta mendorong mitra untuk semakin berdaya secara ekonomi melalui produksi dan pemasaran lip balm Parijoto (LIPJAR) secara mandiri. Rangkaian kegiatan dilaksanakan dalam 3 tahap dalam bentuk workshop (pelatihan), meliputi tahap pengetahuan tentang kosmetik dan buah Parijoto, praktik pembuatan LIPJAR, dan tata cara perijinan kosmetik langsung oleh Dinas Kesehatan Kabupaten Kudus. Hasil dari kegiatan ini adalah mitra menjadi lebih teredukasi tentang pembuatan lip balm, penggunaannya, mampu membuat lip balm Parijoto secara mandiri, lebih memahami tata cara serta strategi tahapan pemasaran produk lip balm Parijoto (LIPJAR), baik secara online maupun offline.

Lip balm is very popular for woman as lip moisturizer. This product commonly using synthetic pigment for charming pigmentation, but we know that synthetic pigment has many side effects. It is still rare for lip balm product using natural pigment that more friendly and useful for consumer and environment. Parijoto fruits that very familiar as special fruits from Kudus, its natural pigment hasn’t been explored. In this community service activity, innovation is using Parijoto juice extract for lip balm pigment. The aim of this community service is to empowering Nasyiatul Aisyiyah community in Kudus as partner in economic development via Parijoto lip balm (LIPJAR) production and marketing. Three stages workshop activities has been carried out, first about knowledge of cosmetic and Parijoto fruit, LIPJAR manufacturing practice, and procedure to get cosmetic product license, especially LIPJAR. The outcome of this activity are partner have been more educated about lip balm production, its application, can make Parijoto lip balm by themselves, more figure out to get a license for lip balm product and step of LIPJAR marketing, both online and offline.
Menumbuhkan Kesadaran dan Keterlibatan Sosial Mahasiswa: Best Practice Dalam Perkuliahan Mata Kuliah Filantropi Pendidikan
Authors: Novi Andriani  , Heru Sulistya  , Sedya Santosa  , Adrian  
Published: September 2023

Abstract: This study aims to analyze whether the educational philanthropy learning model can foster student awareness and social engagement. The research used a qualitative approach. Data collection techniques are carried out by participatory observation techniques, where researchers are directly involved during lectures through presentation activities and in-depth interviews. The resource persons in this study were lecturers who taught educational philanthropy, students of the Islamic Religious Education Management (MPI) study program classes A, B and C. After the data is collected it is then analyzed by data reduction. Then the presentation of the data is used so that it can be accessed and understood easily. The next stage draws conclusions. The results of this study show that the educational philanthropy learning model can foster student awareness and involvement and can create an independent character, but there are still several factors that become obstacles in learning educational philanthropy courses, namely students are still not on time in collecting mini research report assignments that have been determined by lecturers who teach educational philanthropy courses.

Abstrak: Penelitian ini bertujuan untuk menganalisis apakah model pembelajaran filantropi pendidikan dapat menumbuhkan kesadaran dan keterlibatan sosial mahasiswa. Penelitian menggunakan pendekatan kualitatif. Teknik pengumpulan data dilakukan dengan teknik observasi partisipatif, yaitu peneliti terlibat langsung selama perkuliahan melalui kegiatan presentasi dan wawancara mendalam. Narasumber dalam penelitian ini adalah dosen pengampu mata kuliah filantropi pendidikan dan mahasiswa program studi Manajemen Pendidikan Agama Islam (MPI) kelas A, B dan C. Setelah data dikumpulkan kemudian dianalisis dengan reduksi data. Kemudian penyajian data tersebut digunakan agar dapat diakses dan dipahami dengan mudah. Tahap selanjutnya menarik kesimpulan. Hasil dari penelitian ini menunjukkan bahwa model pembelajaran filantropi pendidikan dapat menumbuhkan kesadaran dan keterlibatan mahasiswa serta dapat menciptakan karakter yang mandiri, akan tetapi masih ada beberapa faktor yang menjadi kendala dalam pembelajaran mata kuliah filantropi pendidikan yaitu mahasiswa masih belum tepat waktu dalam pengumpulan tugas laporan mini research yang telah ditentukan dosen pengampu mata kuliah filantropi pendidikan.
Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery
Authors: Asher Shyamal R. , Ong Chin Siang , Malapero Raymond J. , Heydarpour Mahyar , Malzberg Gregory W. , Shahram Jasmine T. , Nguyen Thy B. , Shook Douglas C. , Shernan Stanton K. , Shekar Prem , Kaneko Tsuyoshi , Citro Rodolfo , Muehlschlegel Jochen D. , Body Simon C. 
Published: September 2023

ObjectivesIt is uncertain whether concurrent mitral valve repair or replacement for moderate or greater secondary mitral regurgitation at the time of coronary artery bypass graft or aortic valve replacement surgery improves long-term survival.MethodsPatients undergoing coronary artery bypass graft and/or aortic valve replacement surgery with moderate or greater secondary mitral regurgitation were reviewed. The effect of concurrent mitral valve repair or replacement upon long-term mortality was assessed while accounting for patient and operative characteristics and mitral regurgitation severity.ResultsOf 1,515 patients, 938 underwent coronary artery bypass graft or aortic valve replacement surgery alone and 577 underwent concurrent mitral valve repair or replacement. Concurrent mitral valve repair or replacement did not alter the risk of postoperative mortality for patients with moderate mitral regurgitation (hazard ratio = 0.93; 0.75–1.17) or more-than-moderate mitral regurgitation (hazard ratio = 1.09; 0.74–1.60) in multivariable regression. Patients with more-than-moderate mitral regurgitation undergoing coronary artery bypass graft-only surgery had a survival advantage from concurrent mitral valve repair or replacement in the first two postoperative years (P = 0.028) that did not persist beyond that time. Patients who underwent concurrent mitral valve repair or replacement had a higher rate of later mitral valve operation or reoperation over the five subsequent years (1.9% vs. 0.2%; P = 0.0014) than those who did not.ConclusionsThese observations suggest that mitral valve repair or replacement for more-than-moderate mitral regurgitation at the time of coronary artery bypass grafting may be reasonable in a suitably selected coronary artery bypass graft population but not for aortic valve replacement, with or without coronary artery bypass grafting. Our findings are supportive of 2021 European guidelines that severe secondary mitral regurgitation “should” or be “reasonabl[y]” intervened upon at the time of coronary artery bypass grafting but do not support 2020 American guidelines for performing mitral valve repair or replacement concurrent with aortic valve replacement, with or without coronary artery bypass grafting.
Impact of a heart failure multidisciplinary clinic on the reduction of healthcare-related events and costs: the GEstIC study
Authors: Rego Rita , Pereira Nuno , Pinto António , Pereira Sofia , Marques Irene 
Published: September 2023

IntroductionHeart failure (HF) is the leading cause of hospitalization in the elderly in developed countries and significantly impacts public health expenditures. Patients with HF usually have associated comorbidities that require multidisciplinary management. This study aims to demonstrate the benefits of a multidisciplinary clinic in reducing all-cause hospitalizations and HF events (HF hospitalizations and urgent HF visits) in a real-world setting. Finally, the study evaluates the associated costs of HF events.MethodsThis observational study included patients admitted to GEstIC, a multidisciplinary Portuguese HF clinic, from January 2013 to February 2019, who had one-year follow-up. Hospitalizations and HF events, total days spent in the hospital during HF hospitalizations, and HF events-related costs, in the year before and the year after GEstIC admission, were compared.ResultsOf the 487 patients admitted to the GEstIC, 287 were eligible for the study sample. After one year of HF patients' multidisciplinary management at GEstIC, there was a 53.7% reduction in all-cause hospitalizations (462 vs. 214), a 71.7% reduction in HF hospitalizations (392 vs. 111), and a 39.1% reduction in urgent HF visits (87 vs. 53). As a result, there was a significant decrease of 12.6 days in the length of hospital stay due to HF per patient (15.6 vs. 3.0, p &lt; 0.001). This translated into the release of 9.9 hospital beds in the year following admission to GEstIC. The average total savings associated with the reduction of HF events was €5,439.77 per patient (6,774.15 vs. 1,334.38, p &lt; 0.001), representing a total cost reduction of €1,561,213. Furthermore, the significant reduction in the number of all events was independent of the patient's left ventricular ejection fraction (LVEF).DiscussionSignificant reductions in all-cause and HF hospitalizations and urgent HF visits were observed with the implementation of this multidisciplinary clinic for HF patients' management. This was particularly important for patients with LVEF &gt;40%. Before GEstIC, there was no medical intervention to improve the prognosis of these patients. The reduction of over one million euros in health-related costs after only one year of person-centered multidisciplinary management highlights the need to replicate this approach in other national healthcare institutions.
A retrospective audit of young adults who received permanent pacemakers at a teaching hospital in the Western Cape, South Africa
Authors: Hugo Elrike , Doubell Anton , Steyn Jan , Moses Jane 
Published: September 2023

IntroductionWhile most pacemaker implantations occur in older individuals, younger patients also receive pacemakers. In these, degenerative conduction system disease is less likely to be the cause of atrioventricular block (AVB), with other diseases being more common. There is, however, a paucity of data on this group as well as on younger pacemaker recipients that have undergone pacemaker implantation for reasons other than AVB. The aim of this study was to perform an audit of young adult permanent pacemaker recipients.MethodThis was a retrospective record review, conducted in the Division of Cardiology at Tygerberg Hospital, Cape Town, South Africa. We included 169 adult patients between the ages of 18 and 60, who received permanent pacemakers between 2010 and 2020. A subgroup analysis of patients 55 years and younger was also performed.ResultsThird degree AVB was the most common indication for pacemaker implantation (n = 115; 68%), followed by high degree AVB (n = 23; 13.6%) and sick sinus syndrome (SSS; n = 14; 8.3%). A specific underlying cause for conduction system abnormalities was found in only 25.4% of patients (n = 43), with most of them being 55 years or younger (n = 32; 30.8% of patients ≤ 55 years). Specific causes that were identified included prosthetic valve implantation and/or valve repair (n = 14; 8.3%), myocardial infarction (n = 6; 3.6%), cardiac sarcoidosis (n = 5; 3.0%), coronary artery bypass grafting (n = 3; 1.8%), cardiomyopathy (n = 2; 1.2%), muscular dystrophy (n = 2; 1.2%), congenital heart disease (ventricular septal defect; atrioventricular septal defect; Tetralogy of Fallot; bicuspid aortic valve; n = 6; 3.6%), acute myocarditis (n = 1; 0.6%), atrial myxoma removal (n = 1; 0.6%), planned AV node ablation (n = 2; 1.2%), and following a previous stab in the chest (n = 1; 0.6%).ConclusionGiven that the mean age of our study population was high, the low number of identified underlying causes in the whole cohort (≤60 years) may reflect some AVB due to age related degeneration of the conductions system in the patients 56 to 60 years age, but also raises the possibility that these patients may be less likely to be extensively investigated for an underlying cause than those ≤55 years, where diseases such as sarcoidosis were more readily confirmed. As access to advanced diagnostic tools improves, the percentage of young pacemaker recipients with an underlying cause identified may increase.
Clinical outcomes of takotsubo syndrome in patients with cancer: a systematic review and meta-analysis
Authors: Osawa Takumi , Tajiri Kazuko , Ieda Masaki , Ishizu Tomoko 
Published: September 2023

BackgroundRecent studies suggested a relationship between Takotsubo syndrome (TTS) and malignancy. However, clinical outcomes of TTS associated with cancer have not been assessed completely. This study was aimed to investigate the outcomes of patients with TTS and cancer.MethodsWe performed a systematic review and meta-analysis to evaluate the clinical outcomes of TTS in patients with and without malignancy. We systematically reviewed and analyzed 14 studies (189,210 patients) published in PubMed and Cochrane Library databases until December 2022. The primary outcome was all-cause mortality at the longest follow-up.ResultsThe prevalence of current or previous malignancy in patients with TTS was 8.7% (16,461 patients). Patients with TTS and malignancy demonstrated a higher risk of mortality at the longest follow-up than those with TTS alone (odds ratio [OR], 2.41; 95% confidence interval [CI]; 1.95–2.98; P &lt; 0.001). Moreover, cancer was significantly associated with an increased risk of in-hospital or 30-day mortality (OR 2.36; 95% CI, 1.67–3.33; P &lt; 0.001), shock (OR 1.42; 95% CI, 1.30–1.55; P &lt; 0.001), mechanical respiratory support (OR 1.68; 95% CI, 1.59–1.77; P &lt; 0.001), arrhythmia (OR 1.27; 95% CI, 1.21–1.34; P &lt; 0.001), and major adverse cardiac events (OR 1.69; 95% CI, 1.18–2.442; P &lt; 0.001).ConclusionsThis study revealed significant associations between previous or active cancer and an increased risk of all-cause mortality and in-hospital adverse events in patients with TTS.
A genome-wide association study coupled with machine learning approaches to identify influential demographic and genomic factors underlying Parkinson’s disease
Authors: Rahman Md Asad , Liu Jinling 
Published: September 2023

Background: Despite the recent success of genome-wide association studies (GWAS) in identifying 90 independent risk loci for Parkinson’s disease (PD), the genomic underpinning of PD is still largely unknown. At the same time, accurate and reliable predictive models utilizing genomic or demographic features are desired in the clinic for predicting the risk of Parkinson’s disease.Methods: To identify influential demographic and genomic factors associated with PD and to further develop predictive models, we utilized demographic data, incorporating 200 variables across 33,473 participants, along with genomic data involving 447,089 SNPs across 8,840 samples, both derived from the Fox Insight online study. We first applied correlation and GWAS analyses to find the top demographic and genomic factors associated with PD, respectively. We further developed and compared a variety of machine learning (ML) models for predicting PD. From the developed ML models, we performed feature importance analysis to reveal the predictability of each demographic or the genomic input feature for PD. Finally, we performed gene set enrichment analysis on our GWAS results to identify PD-associated pathways.Results: In our study, we identified both novel and well-known demographic and genetic factors (along with the enriched pathways) related to PD. In addition, we developed predictive models that performed robustly, with AUC = 0.89 for demographic data and AUC = 0.74 for genomic data. Our GWAS analysis identified several novel and significant variants and gene loci, including three intron variants in LMNA (p-values smaller than 4.0e-21) and one missense variant in SEMA4A (p-value = 1.11e-26). Our feature importance analysis from the PD-predictive ML models highlighted some significant and novel variants from our GWAS analysis (e.g., the intron variant rs1749409 in the RIT1 gene) and helped identify potentially causative variants that were missed by GWAS, such as rs11264300, a missense variant in the gene DCST1, and rs11584630, an intron variant in the gene KCNN3.Conclusion: In summary, by combining a GWAS with advanced machine learning models, we identified both known and novel demographic and genomic factors as well as built well-performing ML models for predicting Parkinson’s disease.