bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Risk Factors for Lupus Nephritis
Authors: LI Shan , TIAN Qilong , WANG Hui , WANG Wenqiao , ZHANG Yan 
Published: December 2023

Abstract
Background
Lupus nephritis (LN) is the most common cause of kidney injury in systemic lupus erythematosus and a major risk factor for morbidity and mortality, genetic and environmental factors likely contribute to LN, however, the pathogenesis of LN is still unclear. The purpose of this study is to analysis the risk factors of LN and predicts clinical prognosis.
Methods
A total of 736 systemic lupus erythematosus (SLE) were included, according to urinary protein quantification have been divided into LN group and without LN group, collected their clinical characteristics and analyzed.
Results
The levels of WBC(5.24 ± 0.21vs4.47 ± 0.13)x109/L,NEU(3.72 ± 0.18vs3.00 ± 0.11)x109/L,NLR(4.50 ± 0.30vs3.66 ± 0.25),FAR(0.12 ± 0.01vs0.08 ± 0.01),BAR(0.35 ± 0.02vs0.16 ± 0.02),CAR(0.53 ± 0.07vs0.33 ± 0.03),NAR(0.14 ± 0.01vs0.09 ± 0.01),DAR(0.13 ± 0.01vs0.06 ± 0.01),ESR(61.21 ± 2.23vs46.28 ± 1.55)mm/h,ALT(58.96 ± 7.08vs40.76 ± 3.50)U/L,UA(375.64 ± 8.86vs276.93 ± 4.60)umol/L,Cr(91.10 ± 6.82vs52.47 ± 1.56)umol/L,BUN(8.83 ± 0.51vs5.48 ± 0.62)mmol/L,TC(4.38 ± 0.10vs3.65 ± 0.04)mmol/L,TG(2.13 ± 0.09vs1.56 ± 0.04)mmol/L,LDL(2.33 ± 0.06vs1.91 ± 0.03)mmol/L,Fib(3.18 ± 0.07vs2.90 ± 0.05)g/L,FDP(8.50 ± 0.61vs5.41 ± 0.34)ug/mL,D-D(3.28 ± 0.26vs2.08 ± 0.15)ug/mL, LDH(292.87 ± 12.84vs242.24 ± 7.51)U/L,α-HBDH(244.75 ± 8.66vs203.90 ± 5.69)U/L and Cys C (1.94 ± 0.07vs1.25 ± 0.02)mg/L were increased significantly in LN group (p < 0.05);the levels of RBC(3.32 ± 0.04vs3.74 ± 0.03)x1012/L,HGB(95.30 ± 1.23vs108.31 ± 0.96)g/L,ALB(28.46 ± 0.39vs35.85 ± 0.24)g/L,C3(0.48 ± 0.02vs0.68 ± 0.01)g/L and C4(0.09 ± 0.00vs0.12 ± 0.00)g/L were decreased obviously (p < 0.05),the positive rate of anti-double-stranded (ds) DNA (54.54%vs36.23%) was higher in LN group (p < 0.05). FAR(r = 0.151), CAR(r = 0.166), ALB(r = 0.290), Fib(r = 0.366) and TC(r = 0.194) were positively correlated with complement C3 (p < 0.05); BAR(r=-0.162), LDH(r=-0.129), α-HBDH(r=-0.152) and IgG(r=-0.144)were negatively correlated with complement C3 (p < 0.05); NAR(r = 0.045), DAR(r=-0.08), TG(r=-0.048), LDL-c(r = 0.113), D-D(r=-0.06) and FDP(r=-0.068) were no correlated with complement C3 (p > 0.05); CAR (OR 0.751,95%CI 0.579–0.975; p = 0.032), DAR (OR 1.063, 95%CI 1.011–1.118; p = 0.025), ALB (OR 0.807,95%CI 0.732–0.891; p = 0.001), TC (OR 1.517,95%CI 1.109–2.076; p = 0.009) and D-D (OR 0.592, 95%CI 0.369–0.950; p = 0.03) were LN risk factors.
Conclusion
The levels of WBC, NEU, NLR, FAR, BAR, CAR, NAR, DAR, ESR, ALT, UA, Cr, BUN, TC, TG, LDL, Fib, FDP, D-D, LDH,α-HBDH and Cys C were increased in LN patients, and the levels of RBC, HGB, ALB, C3 and C4 were decreased. CAR, DAR, ALB, TC and D-D were the risk factors for LN patients.
Breeding high-yield pullulan engineering strains of Aureobasidium pullulans by ARTP mutagenesis and transcriptome analysis
Authors: Bai Ruoxuan , Chen Jiale , Hao Yaqiao , Dong Yiheng , Ren Keyao , Gao Ting , Zhang Shuting , Xu Fangxu , Zhao Hongxin 
Published: December 2023

Abstract

Pullulan is a microbial exopolysaccharide produced by Aureobasidium sp. with excellent physical and chemical properties, resulting in great application value. In this study, a novel strain of Aureobasidium pullulans with high pullulan yield up to 51.03 ± 1.03 g·L− 1 isolated from the rhizosphere soil of plants in Taihu Lake in Wuxi, China was subjected to atmospheric and room temperature plasma (ARTP) mutagenesis, followed by selective and optimization to obtain high-yield and high-quality strains. Finally, two pullulan high-yielding and stable genetic mutants Mu0816 and Mu1519 were obtained, with polysaccharide yields after 72-hour fermentation were of 58.71 ± 0.78 and 60.03 ± 0.75 g·L− 1, representing 15.05 and 17.64% increases compared with the original strain, respectively. Transcriptome sequencing was performed on the mutants and the original strain. Transcriptional analysis revealed that the high expression of abhd, gh18 and spMFS in the mutants may be related to the synthesis and secretion of pullulan. These results demonstrated the effectiveness of ARTP mutagenesis in A. pullulans, providing a basis for the investigation of genes related to pullulan production and metabolism.
Tenuifolin suppresses mitophagy via the PINK1/Parkin pathway as a potential therapeutic approach for Parkinson's disease models
Authors: Zhang Xinyue , Yao Menglin , Wang Ting , Chen Hao , Zeng Rui , Hao Guanghui , Wu Dan , Li Huayun , Yang Sijin , Zhao Yueshui , Shen Hongping , Sun Qin 
Published: December 2023

Abstract
Objective
The occurrence of Parkinson's disease (PD) may be caused by mitophagy, and we tried to find out the clues that Tenuifolin (TEN) alters mitophagy.
Methods
The effects of TEN on mitophagy and PINK1/Parkin pathway were detected by ELISA, RT-qPCR, western blot and electron microscopy in rotenone-induced PD rats and PC12 cells.
Results
ROT can establish a rat model of PD, with PD-related behavioral and brain pathological changes. TEN administration can improve the appearance and behavior of PD model rats, reduce the expression of Parkin, PINK1, Beclin-1, LC3II/I and other related autophagy proteins in the brain tissue of PD model rats and PC12 cells, alleviate the damage of cell mitochondria, and protect the brain nerve.
Conclusion
PINK1/Parkin pathway may be one of the mechanisms of TEN to treat PD via alleviating the damage of cell mitochondria and protecting the brain nerve, and it provides a new way to treat Parkinson's disease.
Reseña de “Love, friendship and storytelling. Talking with young people about the best-loved works of their generation”
Authors: Fernández Fernández Iñigo 
Published: December 2023

El texto es una breve reseña del siguiente libro:González Gaitano, N., Bellido, G. y Galatolo, C. (2023). Love, friendship and storytelling. Talking with young people about the best-loved works of their generation. EDUSC.
Tigres, morenos y pragmáticos en el Facebook. Los ethos de los candidatos a gobernador de Coahuila en 2023
Authors: Andrade del Cid Patricia , Pablo Contreras Mariangel 
Published: December 2023

Con el objetivo de identificar ámbitos de la cultura política se analizaron los enunciados emitidos en los perfiles de Facebook por tres candidatos a la gubernatura de Coahuila del 2023 en México: Manolo Jiménez (PRI/PAN/PRD), Armando Guadiana (Morena) y Ricardo Mejía (PT), durante la campaña electoral realizada durante los meses de abril y mayo de 2023. Con la herramienta Search de la aplicación de Meta Crowdtangle se buscaron las publicaciones emitidas por esos tres candidatos. La base descargada incluye el texto de la publicación, el número de reacciones, el número de comentarios, la fecha de creación y el URL a la publicación en Facebook. Los resultados exploran los discursos donde los candidatos expresan sus ethos -o imágenes que se construyen de sí mismos- a través de hipérboles y sinécdoques de la argumentación, representando de esa manera las esferas la cultura política de esa región de México.
Silt Density Index
Authors: Duranceau Steven J. 
Published: December 2023

Abstract
The most widely accepted and historically used predictor of the fouling potential of reverse osmosis feedwater is the plugging factor (PF), now commonly known as the Silt Density Index (SDI). The SDI procedure was standardized by ASTM International and is intended to be used as a measure of the fouling capacity of feedwater to reverse osmosis systems. The SDI is an index calculated from a test that measures the rate at which a 0.45-micrometer (μm) filter is plugged when subjected to a constant water pressure of 206.8 kPa (30 psi). The SDI gives the percent drop per minute in the flow rate of the water through the filter, averaged over a specified time-period, typically 15 minutes. Because the SDI is a relatively simple procedure and inexpensive to implement, it has been universally applied since the 1960s to assess the particulate fouling tendency of a feedwater intended for treatment by reverse osmosis (RO) membrane processes. Many facilities in the United States rely on automated SDI systems that are microprocessor controlled and fully automatic to allow operators to regularly monitor the feedwater. Care must be taken when employing the SDI with regards to accuracy and reproducibility, as the index is not based on any filtration mechanism and is not proportional with colloidal or particle concentration, in addition to the fact that there is no correlation factor for temperature nor for variations in membrane resistance. Even though there are legitimate concerns regarding the predictive value of the SDI, the index continues to be successfully used in the planning of RO facilities to guide the selection of pretreatment processes, and is often the basis of membrane guarantees and other plant performance contracts.
Screening and Retaining Adolescents Recruited Through Social Media: Secondary Analysis from a Longitudinal Clinical Trial
Authors: Weisblum Margaret , Trussell Emma , Schwinn Traci , Pacheco Andrea R , Nurkin Paige 
Published: December 2023

Background
Social media has become a popular method to recruit participants, particularly for studies with hard-to-reach populations. These studies still face challenges in data quality and, for longitudinal studies, sample retention. However, in addition to aiding in recruitment, social media platforms can help researchers with participant verification and tracking procedures during the study. There is limited previous research describing how longitudinal studies can use social media to screen and retain participants.

Objective
This paper describes strategies implemented to screen and retain a nationwide sample of sexual minority youth who were recruited through social media platforms for a longitudinal study testing a drug abuse prevention program.

Methods
Our screening strategies for participants included collecting necessary demographic information (name, phone, email, and social media accounts), verifying this information using publicly available web-based records, and sending confirmation emails to ensure working email addresses and correct dates of birth. Retention strategies included communications designed to develop positive participant relationships, incentives for survey completion, regular updating of participant contact information, targeting hard-to-reach participants, and using social media as an alternative means of contacting participants.

Results
During enrollment, although the only demographic data required were a phone number and an email address, 87.58% (1065/1216) of participants provided their Instagram as an alternative means of contact. This form of alternative communication remains the most preferred with 87.40% (1047/1198) of participants continuing to provide an Instagram username as of January 2023, about 3 years after recruitment began. In comparison, other alternative means of contact (eg, Facebook and alternative email) were provided by only 6.43% (77/1198) to 56.18% (673/1198) of participants. Direct messaging on Instagram was used to successfully confirm participant identity, remind participants to take annual follow-up surveys, and update lost participant contact information. Screening and retention strategies used in the study have helped achieve 96.30% (1171/1216) to 96.79% (1177/1216) sample retention across 3 waves of data collection.

Conclusions
Though social media can be a helpful tool to recruit participants, attrition and participant authenticity difficulties may be associated with this method. Screening and retention strategies can be implemented to improve retention. Internet searches are effective for screening youth to ensure they meet eligibility requirements. Additionally, social media—Instagram in this study—can help to track and locate participants who do not respond to traditional contact methods.

Trial Registration
ClinicalTrials.gov NCT03954535; https://clinicaltrials.gov/study/NCT03954535
ANTIOXIDANTS SUPPLEMENTATION BASED ON NATURAL PRODUCTS IN THE TREATMENT OF THE THERMAL SKIN INJURY
Authors: Krstić Miloš , Krstić Bojana 
Published: December 2023

Thermal injuries are a major medical, economic and social problem, whose severity, morbidity, mortality, prognosis and treatment outcome directly depend on the surface and depth of the burn, but also on the patient's age, health status and accompanying complications. The treatment of thermal injury is long and complex, and the outcome is often uncertain with a very complex rehabilitation process, because the injury damages both physical and psychological health. Constant innovations in the protocol of medical treatment and the search for new mechanisms involved in the pathogenesis of burns can be helpful in successful treatment. Therefore, there is a constant search for adjuvant therapies that will improve results like HBO, AO, platelet- rich plasma, negative pressure wound therapy and others. In recent years, the application of antioxidants as adjuvant therapy for the care and treatment of wounds has been the subject of various researche. Antioxidants are biologically active molecules that prevent the creation of free radicals in the body and at the same time neutralize the existing ones, this way participating in maintaining the oxidative status at the desired level. Antioxidant -rich natural products may provide a solution to improve wound healing. The application of antioxidant therapy has shown numerous benefits in improving the outcome of burns. However, more information is needed from the clinical trials on the use of natural products, especially in combination with other therapies. Keywords: thermal skin injury, hyperbaric oxygen therapy, antioxidant rich natural products
Latihan keterampilan sosial: Teknik meningkatkan kemampuan interaksi sosial skizofrenia
Authors: Putri Anisa Novita 
Published: December 2023

Subject is a man. He is 34 years old. He often alone and do not want to interact with the people around him. The assessments use interviews, observations and psychological tests (Sack Sentence Completion Test, Wechsler Adult Intelligence Scale, Grafis, Wartegg, Thematic Apperception Test). The results of the assessment and referral from the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) concluded that the subject met the diagnostic criteria for 295.90 (F20.9) schizophrenic disorder with behavioral problems. Subject was did not want to interact with people around him, the subject often daydreams and speak by his selves. The intervention was carried out social skills training. Social skills training can improve social interaction. The social interaction that is taught aims to enable the subject to interact with people around him, establish communication or inviting people to speak and make eye contact during interactions. The research results showed that subject began to be able to interact with the people around him, but did not last long because sometimes the subject still choose to be alone. However, the subject is still accompanied with people around him.

Subyeknya adalah seorang laki-laki. Dia berusia 34 tahun. Ia sering menyendiri dan tidak mau berinteraksi dengan orang-orang disekitarnya. Penilaiannya menggunakan wawancara, observasi dan tes psikologi (Sack Sentence Completion Test, Wechsler Adult Intelligence Scale, Grafis, Wartegg, Thematic Apperception Test). Hasil asesmen dan rujukan dari Diagnostic and Statistical Manual of Mental Disorders (DSM-5) menyimpulkan bahwa subjek memenuhi kriteria diagnostik gangguan skizofrenia 295,90 (F20.9) dengan masalah perilaku. Subjek tidak mau berinteraksi dengan orang disekitarnya, subjek sering melamun dan berbicara sendiri. Intervensi yang dilakukan adalah pelatihan keterampilan sosial. Pelatihan keterampilan sosial dapat meningkatkan interaksi sosial. Interaksi sosial yang diajarkan bertujuan agar subjek dapat berinteraksi dengan orang disekitarnya, menjalin komunikasi atau mengajak orang berbicara dan melakukan kontak mata saat berinteraksi. Hasil penelitian menunjukkan bahwa subjek mulai dapat berinteraksi dengan orang-orang disekitarnya, namun tidak bertahan lama karena terkadang subjek masih memilih untuk menyendiri. Namun subjek tetap ditemani oleh orang-orang disekitarnya.
Speech Your Colors!: Mengurangi Kecenderungan Social Withdrawal Pada Anak Usia 6-10
Authors: Levi Tifara , Jesslyn Anastasia , Hadibroto Marissa Gabriele , Cheriselyn Jessica Natalie , Yulianto Jony  Eko 
Published: December 2023

This study conducts an intervention in the form of an innovative and interactive game titled Speech Your Colors! to reduce the tendency of social withdrawal in children aged 6-10. The participants for this intervention consisted of 33 second grade students from Sekolah Citra Berkat, Surabaya. This game was conducted for a single session with the duration of 90 minutes with supervision and direct data collection done by the research team and homeroom teacher as a spectator. A one-group posttest design was used which included items from the HQ-25 scale for social withdrawal. Results received from the observation, feedback, and posttest show that participants developed the desire to continuously interact with their peers whereas they tend to avoid social interactions beforehand. In addition, participants report positive feelings towards the intervention process as well as towards their peers. Therefore, it can be concluded that Speech Your Colors! can effectively decrease social withdrawal tendencies in children aged 6-10.

Penelitian ini melakukan intervensi berupa permainan inovatif dan interaktif bertajuk Speech Your Colors! untuk mengurangi kecenderungan penarikan diri dari pergaulan pada anak usia 6-10 tahun. Peserta intervensi ini terdiri dari 33 siswa kelas dua Sekolah Citra Berkat, Surabaya. Permainan ini dilakukan dalam satu sesi dengan durasi 90 menit dengan pengawasan dan pengumpulan data langsung yang dilakukan oleh tim peneliti dan wali kelas sebagai penonton. Desain posttest satu kelompok digunakan yang mencakup item dari skala HQ-25 untuk penarikan diri dari sosial. Hasil yang diperoleh dari observasi, feedback, dan posttest menunjukkan bahwa partisipan mengembangkan keinginan untuk terus berinteraksi dengan teman sebayanya sedangkan mereka cenderung menghindari interaksi sosial sebelumnya. Selain itu, peserta melaporkan perasaan positif terhadap proses intervensi serta terhadap rekan-rekan mereka. Oleh karena itu, dapat disimpulkan bahwa Speech Your Colors! dapat secara efektif mengurangi kecenderungan penarikan diri dari pergaulan pada anak usia 6-10 tahun.
Yoga em contextos escolares como instrumental da aprendizagem e da saúde coletiva
Authors: Sales Pires Cristiane , De Almeida Pimenta Maria Alzira 
Published: December 2023

O Yoga é uma prática milenar corpo-mente especializada na conscientização da atenção, na regulação do estresse e das emoções por meio de práticas respiratórias, posturas corporais, relaxação e meditação. Neste artigo, procurou-se responder à pergunta: em que estado se encontram as pesquisas que justificam o uso do Yoga com vistas à melhoria do processo de aprendizagem dos estudantes? Realizou-se pesquisa bibliográfica para compreender os fundamentos que apontam para a implantação do Yoga em contexto escolar. Dentre os resultados, foram encontrados estudos que categorizam os efeitos do Yoga; a adequação da prática às estratégias de aprendizagem socioemocional e à programas de práticas contemplativas; e as razões que apontam para o uso do Yoga com vista à aprendizagem e à saúde coletiva.
Hubungan Indonesia-Malaysia: Perspektif Budaya dan Keserumpunan Melayu Nusantara
Authors: Zed Mestika 
Published: December 2023

This working paper aims to discuss the relationship between Indonesia and Malaysia in the perspective of culture, especially in the light of the spirit of a kinship-relation of Melayu Nusantara (the Malay Archipelago). Both cultural concept and cluster spirit are basic elements and form an eternal 'determinant', but its meaning and forms could change over the time. This might be so because many contemporary issues are also clouded by many factors, either internal or external. There are many cases could be dicussed in terms of recently called as a cultural diplomacy. The most crucial cases in recent, among others, are the problem of migrant workers, border issues and cultural claims between the two countries. However, when we examined furthermore, it seems that many cases that appear on the surface recently had been actually more complicated than that of we could understand so far. This working paper will address the following questions: 1) How could we understand the concept of culture and kinship-cluster between Indonesia and Malaysia in the context of the past and present? 2) Does cultural, religion and kinship-cluster similiarities which are shaped through a long historical process colud be helpful for explaining and solving recent problems? 3) How could we read contemporary critical issues in bilateral relations between the two countries by way of using the lens a cultural diplomacy on behalf the spirit of kinship-cluster of Malay Archipelago? And 4) Based on this persepctive, what are then the concrete steps that can be done in addressing critical issues in relations between the two countries today? It will aslo discuss some of the challenges involving future bilateral relations. A conclusion will close this paper.Keywords: Melayu Nusantara, cultural diplomacy, kinship-cluster and bilateral relation.
EKSISTENSI DAN INDEPENDENSI SURAT KABAR DALAM KOMUNIKASI POLITIK PADA PILKADA DALAM RANGKA PENDIDIKAN DEMOKRASI
Authors: Saputra Edi 
Published: December 2023

Theoretically, in the context of the establishment of the democratic process, the existence of newspapers in political communication on the elections should be independent. It means that newspapers should be able to investigate in a professional, freely without bias from any parties, be objective in reporting the facts or events that occurred in the elections so as to form an opinion that does not harm anyone in increasing confidence of the people for making their choices. Methodologically, the independence of a newspaper can be measured by the Content Analysis Method in the editorial, whether the editor has the discretion to review the news, issues, or events that occur in the elections, or whether it was influenced or not influenced by certain parties, particularly candidates in the elections. In addition, the independence of the newspapers can also be seen from the attitude of the editor in the editorial, whether it be supportive, neutral, or not being supportive.Keywords: Existence, independency, political communication, local elections, demo-cratic process
在人工智能時代需要謹慎對待腦機介面技術
Authors: 張 言亮 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
The essay “The Ethics of Thinking with Machines: Brain-Computer Interfaces in the Era of Artificial Intelligence” summarizes the author’s fundamental views. It points out that we need to be cautious about brain–computer interface technology. In particular, we should be cautious when dealing with forms of such technology that may threaten human autonomy, psychological identity, personal identity, and personal privacy, and standardize the development of brain–computer interface technology in accordance with the five principles of technology ethics: improving human well-being, respecting the right to life, upholding fairness and impartiality, reasonably controlling risks, and maintaining open and transparent.