bluuebunny/crossref_metadata_2025_split huggingface dataset:
Very young children are insensitive to picture‐ but not object‐orientation
Authors: Pierroutsakos Sophia L. , DeLoache Judy S. , Gound Mary , Bernard E. Nicole 
Published: June 2005

Abstract In two experiments on very young children's response to the orientation of pictures and objects, 18‐, 24‐ and 30‐month‐old children showed no preference for upright pictures over inverted ones. More importantly, we found that children in all three age groups were equally accurate and equally fast at identifying depicted objects regardless of orientation. These studies further established that young children's insensitivity to picture orientation does not extend to objects. These results, in combination with the earlier ones, indicate that only gradually do young children come to share the picture orientation preference of adults and older children and that their adoption of the orientation convention is not based on changes in their ability to process upright and inverted images.
A7445G mtDNA mutation present in a Portuguese family exhibiting hereditary deafness and palmoplantar keratoderma
Authors: Caria H , Matos T , Oliveira‐Soares R , Santos AR , Galhardo I , Soares‐Almeida L , Dias O , Andrea M , Correia C , Fialho G 
Published: June 2005

ABSTRACTMitochondrial DNA (mtDNA) A7445G point mutation has been shown to be responsible for familial nonepidermolytic palmoplantar keratoderma (NEPPK) associated with deafness without any additional features. To date, only a few cases have been described. We report a Portuguese pedigree presenting an inherited combination of NEPPK and sensorineural deafness compatible with maternal transmission. Clinical expression and age of onset of NEPPK and deafness were variable. Normal expression patterns of epidermal keratins and filaggrin, intercellular junction proteins including connexin 26, loricrin and cornified envelope proteins, were observed. Molecular analysis revealed that all the affected members, previously screened for Cx26 mutations with negative results, presented the mtDNA A7445G point mutation in the homoplasmic form. To our knowledge, this is the fifth family in whom inherited NEPPK and hearing loss are related to this mitochondrial mutation.
Multiple myeloma with scleroderma‐like changes
Authors: Paredes‐Suárez C , Fernández‐Redondo V , Blanco M Vázquez , Sánchez‐Aguilar D , Toribio J 
Published: June 2005

ABSTRACTWe present a case of a patient who presented concomitantly with generalized pruritus, brownish sclerodermatous plaques, sclerodactyly and a monoclonal band for IgG‐kappa. The patient was diagnosed as having multiple myeloma by bone marrow examination. The rapidly progressive evolution with acute anuric renal failure, malignant hypertension and the skin sclerosis seem to be related to the neoplastic disorder. The scleroderma‐like changes have to be differentiated from systemic scleroderma.
Erythema dyschromicum perstans in children: a report of 14 cases
Authors: Torrelo Antonio , Zaballos Pedro , Colmenero Isabel , Mediero Imelda G. , De Prada Inmaculada , Zambrano Antonio 
Published: June 2005

ABSTRACTBackground  Erythema dyschromicum perstans (EDP) or ashy dermatosis is a peculiar, slowly progressive, macular hyperpigmentation, which leaves a permanent discoloration. It is an acquired dermatosis that occurs most frequently in Central and South America. EDP usually appears in adults, but some isolated cases and small series have been reported in prepubertal children.Methods  A retrospective review of cases of EDP in 10‐year‐old children or younger, attended in a pediatric hospital between 1990 and 2003.Results  We present 14 cases of EDC in children 10 years and younger. With an additional 25 cases reported so far in the English language literature, a total of 39 children have been described. Unlike adult patients, who are most commonly of Hispanic origin, children with EDP are usually Caucasian. Other important facts in children with EDP are the absence of consistent trigger factors and an eventual improvement or resolution of the lesions in 50% of prepubertal patients.Conclusion  We suggest that EDP is a distinctive clinical entity, different from lichen planus and lichen planus pigmentosus, which may be identical to the so‐called idiopathic eruptive macular pigmentation.
Screening of Chlamydia trachomatis urogenital infections among the male and female population of the Republic of Macedonia
Authors: Spasovski Miroslav S. , Simjanovska Liljana J. , Taleski Vaso , Petrova Nada , Lazetic Liljana , Popeska Zaneta , Gaydos Charlotte A. , Quinn Thomas C. , Efremov Georgi D. 
Published: June 2005

ABSTRACTBackground  Noninvasive urine screening for Chlamydia trachomatis infections offers a valuable public health tool, that could be of vast importance in Chlamydia control programs.Objective  The goal was to determine the prevalence of C. trachomatis infections among a sexually active population, to define the epidemiological factors associated with it, and to develop potential selective screening strategies among asymptomatic individuals in the Republic of Macedonia, using a highly sensitive and specific DNA amplification method for C. trachomatis.Study design  A total of 1435 urine samples, divided into two main groups: asymptomatic individuals (n = 1210) and symptomatic patients (n = 225), were tested. Samples from the asymptomatic group were collected during routine screening programs, while the symptomatic group consisted of patients with symptoms of urogenital tract infection, attending sexually transmitted diseases (STD) clinics. The presence of C. trachomatis was determined using commercial AMPLICOR C. trachomatis Assay (Roche Diagnostic Systems, Inc., Branchburg, NJ, USA).Results  The prevalence of C. trachomatis infections among different groups was: recruits 0%, soldiers 0.4%, policemen 3.5%, clerks 4.6%, pregnant women 4%, and students 4.4%. The average prevalence for both groups (asymptomatic and symptomatic) was 2.3%[95% confidence interval (CI): 1.5–3.1%]. The average prevalence for the asymptomatic group was 1.6% (95% CI: 0.8–2.4%), while the average prevalence for the symptomatic group was 6.2% (95% CI: 3.1–9.3%) which were significantly different (P = 0.00003).Conclusion  Testing first void urine specimens by AMPLICOR C. trachomatis assay is a highly sensitive and specific method for diagnosing C. trachomatis infections in men and women. This method provides health care workers and public health officials with a new molecular amplification assay that uses noninvasive urine specimens for population‐based screening purposes. The prevalence of C. trachomatis was relatively low among asymptomatic individuals. However, selective screening strategies are highly recommended for testing the student population in the Republic of Macedonia.
Epidermal stem cells
Authors: Barthel R , Aberdam D 
Published: June 2005

ABSTRACTThe identification of adult epidermal stem cells that are capable of self‐renewal and can reconstitute not only the epidermis but also the cutaneous appendages opens new perspectives for the treatment of a variety of human skin disorders including severe burns, cutaneous cancers, alopecia and acne. However, the implementation and improvement of these novel treatment strategies require a better understanding of the biology of stem cells, in particular regarding their isolation and the maintenance of their unique characteristics in culture. In this review, we summarize the main features of epidermal stem cells and we present the most recent advances in our understanding of the development and maintenance of these cells. In addition, we discuss some of the challenges and the potential clinical applications of epidermal stem cell technology.
Stroke and Orgasmic Cephalgia
Authors: Levy Richard L. 
Published: June 2005

SYNOPSISA 24‐year‐old man suffered a stroke in association with orgasmic cephalgia, without evidence of intracranial hemorrhagic disease. It is postulated that this is an example of complicated migraine coincident with sexual climax and that benign orgasmic cephalgia is a migraine variant.
Personality Profiles in Cluster Headache and Migraine
Authors: Cuypers J. , Altenkirch H. , Bunge S. 
Published: June 2005

SYNOPSIS40 cluster headache patients and 49 migraine patients described their personality using the Freiburg Personality Inventory (FPI). Cluster headache patients had a slightly elevated score in scale 1 (nervousness) and a slightly diminished score on scale M (masculinity). On scale 1 migraine patients displayed a score at the upper borderline of the average range. Both groups evidenced normal values in all the other scales. Our results do not favour the view that neurotic mechanisms play a decisive role in these patients.
Lithium Carbonate Has No Measurable Effect on Cerebral Hemodynamics in Cluster Headaches
Authors: Okayasu Hiroyuki , Meyer John Stirling , Mathew Ninan T. , Amano Takahiro , Hardenberg Jeffrey 
Published: June 2005

SYNOPSISAny effects of lithium carbonate (oral dosage 900 mg/day) on measurements of cerebral hemodynamics were examined in 10 carefully selected patients meeting criteria of chronic cluster headache, i.e., headache‐free intervals were less than 3 weeks in duration per year. Cerebral blood flow (CBF) was measured by the 133Xe inhalation method before and 2‐4 weeks after (mean 3 weeks) standard recommended lithium carbonate administration, as a dose of 300 mgs give orally three times per day (total 900 mg/24 hours).Cerebral vasoconstrictor responsiveness was tested by repeated CBF measurements during serial inhalations of 100% O2 followed by 5% CO2 in air mixtures. Mean values for hemispheric gray matter flow were 70.9 ml/100g brain/min measured over the side of the cluster headaches and 70.0 ml over the contralateral side prior to lithium and 68.0 ml for sides of the head after lithium treatment. These differences before and after treatment were not significant. Cerebral vasodilator responsiveness to 5% CO2 was expressed as per cent gray matter flow change per mmHg change of measured PECO2 . Compared to values measured in normal age‐matched controls, CO2 responsiveness was diminished bilaterally, both prior to and during lithium administration and there were no significant changes induced after treatment with the drug. Likewise cerebral vasoconstrictor responses during 100% oxygen inhalation were not altered by lithium treatment.
Migraine, Seizures and Epileptic Focal E.E.G. Abnormalities in a Young Adult: a Nine‐year Follow‐up
Authors: Gil R. , Lefevre J.P. , Burelout Y. 
Published: June 2005

SYNOPSISWe have studied a 24‐year‐old woman followed over a nine year period for episodes of migrainous aura sometimes preceding convulsive seizures and associated with persistent and fluctuant focal and paroxysmal E.E.G. abnormalities: the latter appeared on most recordings and involved the left occipital region. All others investigations remained normal and the clinical course was benign. This case resembles the four cases reported by Camfield et al and an additional case reported by Panayiotopoulos. However our case shows that this syndrome may occur in adults (all the previously reported cases concerned adolescents); moreover our observation shows that convulsive seizures may be or not preceded by migrainous aura, that E.E.G. abnormalities may fluctuate when observed during a long term period (nine years); finally, such as in one case reported by Camfield et al the E.E.G. abnormalities were focal.
Migraine and Cluster Headache: Links Between Platelet Monoamine Oxidase Activity, Smoking and Personality
Authors: Littlewood Julia T. , Glover Vivette , Sandler M. , Petty R. , Peatfield R. , Rose F. Clifford 
Published: June 2005

SYNOPSISThe incidence of smoking in a group of male cluster headache patients (95%) was significantly (P<0.001) greater than in a matched group of male migrainous patients (26%). Both groups had significantly lower platelet monoamine oxidase activity than controls. This finding may be connected genetically with certain personality characteristics, including predisposition to smoke. It is possible that migrainous patients smoke less than those with cluster headache because the process of smoking has a greater tendency to provoke their headache attacks.
Development of a Computer‐assisted Headache Diagnostic and Treatment System
Authors: Francis James H. , Pennal Billy E. , Wadsworth Wynelle 
Published: June 2005

SYNOPSISThe use of a computer for the diagnosis and treatment of headache has been limited; however, studies have suggested its feasibility. In the severe chronic headache sufferer there is difficulty in obtaining and assimilating the diagnostic data. This report describes the first phase of a three‐phase project in implementation of a computer as an aid in actual diagnosis and treatment planning for the chronic headache patient. Input into the computer is accomplished with a patient and a physician questionnaire. The computer sorts, analyzes and compares the data with known diagnostic and treatment criteria and weights the relationships numerically. The results are printed in reports including diagnostic impression and differential diagnosis based on the total value accumulated toward those diagnoses. In addition, information is printed to provide physician and patient information specific to the headache diagnoses. A recommended treatment protocol is given for each headache type. For differential diagnoses, specific confirming tests are recommended. References are provided on the report for the diagnoses found and treatment protocols recommended.
Further Evidence on the Association of Mitral Valve Prolapse and Migraine
Authors: Gamberini G. , D'Alessandro R. , Labriola E. , Poggi V. , Manzoni G.C. , Carpeggiana P. , Sacquegna T. 
Published: June 2005

SYNOPSISTwo populations of patients, one with common migraine and the other with mitral valve prolapse (MVP), were analyzed to define the relationship between these conditions. Of 100 consecutive patients with migraine, 20 had MVP; of 100 consecutive patients with MVP, 51 suffered from migraine headache. As for features of migraine are concerned, the patients with MVP‐migraine association did not significantly differ from the patients with migraine alone. On the basis of reports in the literature, it remains to be seen whether this association involves a greater risk of cerebrovascular events.
Subcutaneous Sumatriptan in Cluster Headache: A Time Study of the Effect on Pain and Autonomic Symptoms
Authors: Hardebo Jan Erik 
Published: June 2005

SYNOPSISA subcutaneous injection of 6 mg sumatriptan rapidly and effectively stopped attacks of cluster headache. After a time lag of 4–14 minutes (mean 7 minutes) pain dramatically dropped to zero within seconds to single minutes (mean 56 seconds). This rapid effect may indicate that mere vasoconstriction is the mechanism behind the beneficial effect of sumatriptan in cluster pain. The findings support a scenario in cluster headache where an inflammation in the cavernous sinus affects the sympathetic fibers traversing the cavernous region. This leads to the miosis, ptosis and forehead anhidrosis but also to a dilated internal carotid arterial tree distal to the lesion. The dilatation, in combination with an obliterated drainage of the cavernous sinus by the inflammatory process, leads to progressive stasis in the sinus, to cause the painful attack. The attack terminates when the enhanced load on the sinus is reduced by constriction of vessels supplying the sinus, as is achieved by administration of sumatriptan. The present observation that other accompanying symptoms during attacks (nasal congestion, rhinorrhea, lacrimation and swelling of eyelids) disappeared in parallel with the pain points to the possibility that these symptoms may be directly related to venous stasis or activation of pain fibers, rather than resulting from a primary parasympathetic activation.
Suggestibility and Headache Reports in Schoolchildren: A Problem in Epidemiology
Authors: Passchier J. , Hunfeld J.A.M. , Jelicic M , Verhage F. 
Published: June 2005

SYNOPSISIn a sample from the general population of school children of 15 years of age, we studied whether receiving information about the prevalence of headaches had any effect on their subsequent headache report. Sixty children in the fourth year at four secondary schools were allocated at random to two conditions: a biased condition emphasizing the high prevalence of headaches and a neutral condition. Subjects in the biased condition reported more headaches but they did not report more other physical symptoms than the subjects in the neutral condition. The results are discussed in terms of Pennebaker's theory on reporting symptoms. It is concluded that epidemiological research using the general population should deal more explicitly with the way in which subjects are motivated to participate.
Computed Tomography in the Headache Patient: Is Routine Evaluation Really Necessary?
Authors: Mitchell Craig S. , Osborn Robin E. , Grosskreutz Scott R. 
Published: June 2005

SYNOPSIS Objective. To determine the likelihood ratio of a positive computed tomogram of the brain in the routine evaluation of headache patients. Design. Consecutive patients with a chief complaint of headache were prospectively evaluated with computed tomography of the brain. Patients with headaches complicating other clinical disorders such as trauma, postictal state or known intracranial neoplasm were excluded. Setting. Military tertiary care center. Patients. Consecutive sample of 350 patients with a chief complaint of headache, regardless of the presence or absence of physical or neurologic signs, were referred for computed tomography of the brain. The patients were referred from a variety of inpatient and outpatient settings. Results. Seven (2%) of the 350 patients had computed tomographic findings that were clinically significant. An additional 25 (7%) had positive computed tomographic findings, which were clinically insignificant for findings. All of the patients with significant computed tomographic findings had an abnormal physical or neurologic exam or unusual clinical symptoms. Conclusion. Routine computed tomography of the brain in headache patients with normal physical and neurologic exams and no unusual clinical symptoms has a low likelihood ratio for discovering significant intracranial disease.
Subcutaneous Sumatriptan in the Treatment of Acute Episodes of Posttraumatic Headache
Authors: Gawel Marek J. , Rothbart Peter , Jacobs Howard 
Published: June 2005

SYNOPSISSeven patients with posttraumatic headaches refractory to other medical treatment were treated with sumatriptan, 6 mg subcutaneously, at the peak of a headache. In all, the throbbing temporal part of the headache disappeared leaving a persistent occipital pain. It is postulated that involvement of the trigeminovascular system is involved in part of the pain of posttraumatic headache, making it amenable to treatment with sumatriptan.
Psychological Status During Migraine Attack and Interval Before and After Treatment With a Selective 5‐HT1‐Agonist
Authors: Göbel Hartmut , Krapat Susanne 
Published: June 2005

SYNOPSISThe study recorded the quantitative changes in psychological status during migraine attack and interval in 20 migraine patients. It further determined their psychological status after administration of the selective 5‐HT1‐agonist sumatriptan and placebo during migraine interval and migraine attack. Psychological status was classified with the aid of an adjective list enabling quantitative description of 15 essential aspects of the subjects' current disposition. The results demonstrate a drastic deterioration in psychological status during an acute migraine attack as compared to the migraine interval and plainly show how badly migraine affects the patients, as almost all the aspects of psychological status are impaired.Administration of placebo did not significantly Influence current disposition either in the migraine interval or during the attack. Sumatriptan minimally increased Inactivity and dizziness during the migraine interval. During an attack sumatriptan completely normalized current disposition within 30 minutes by significantly improving the impaired dimensions. It is conceivable that this rapid normalization is due to the reduction in pain severity and is only a secondary effect of the rapid alleviation of pain. It is also possible that a direct effect of the selective 5‐HT1‐agonist on the central nervous system may be the cause of this rapid normalization of current disposition.
Exteroceptive Silent Periods of Temporalis Muscle Activity: Correlation with Neuropsychological Findings
Authors: Wallasch Thomas‐Martin , Niemann Ulrike , Kropp Peter , Weinschütz Thomas 
Published: June 2005

SYNOPSISThe latency and duration of the early (ES 1) and late (ES 2) exteroceptive silent period of temporalis muscle activity were determined in 51 neurological patients. We investigated whether these electrophysiologicalparameters correlated with neuropsychological variables of the patients using standardized scores for personality index, state of well‐being and physical symptoms. There were no correlations between personality traits and the electrophysiological parameters, while we found significant correlations between the duration of ES 2 and momentary psychological and physical well‐being variables. Moreover, the score of the momentary well‐being item ‘general feeling of well‐being’ was demonstrated to moderate significantly the ES 2 duration (P = 0.018). Therefore, neuropsychological factors prove to be of great relevance to the exteroceptive silent periods of temporalis muscle activity.
Deficiency In Serum Ionized Magnesium But Not Total Magnesium In Patients With Migraines. Possible Role Of Ica2+/IMg2+ Ratio
Authors: Mauskop A. , Altura B.T. , Cracco R.Q. , Altura B.M. 
Published: June 2005

SYNOPSISIt has been suggested that magnesium (Mg) may play a role in the pathogenesis of headaches. Serum and intracellular measurements of Mg in headache patients have produced inconsistent results. The recent development of an ion‐selective electrode for Mg2+ allowed precise measurement of serum ionized magnesium (IMg2+) in patients with various headache syndromes. Low serum Img2+ and a high ICa2+/IMg2+ ratio were found in 42% of patients having an attack of migraine, but only in 23% of patients with e severe continuous headache. Total serum Mg was normal in both groups of patients. However, in patients with low serum IMg2+ total serum Mg was lower than in patients with normal serum IMg2+. These results are compatible with the serotonin and vascular concepts of migraine pathogenesis. Low IMg2+ and a high ICa2+/Img2+ would result in cerebral vasospasm and reduced blood flow in the brain. The activity of serotonin receptors can also be affected by changes in IMg2+ levels. The finding of a difference in IMg2+ levels in two different headache types suggests a possible novel classification of headaches and that migraine patients with a low serum IMg2+ or a high ICa2+/IMg2+ ratio may benefit from Mg supplementation.
Psychophysiological and MMPI Personality Assessment of Headaches: An Integrative Approach
Authors: Williams D.E. , Raczynski J.M. , Domino Julia , Davig J.P. 
Published: June 2005

SYNOPSISMultiple psychophysiological measures and personality assessment techniques were combined to facilitate the diagnosis of headache type and improve upon existing methodology. Twenty‐four migraine, 24 chronic tension headache patients, and 24 normal age‐ and gender‐matched controls were assessed with bilateral measures of frontalis and occipitalis EMG and blood volume pulse. All subjects completed the MMPI. Results suggest that headache subjects could be differentiated on baseline heart rates and MMPI scales 1,2,3, and 7. Only one physiological measure served as an index of psychological distress, suggesting issues of an interaction between psychophysiological and personality variables, as well as the chronicity of the headache.