bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Subcutaneous Spesolimab on the Prevention of Generalized Pustular Psoriasis Flares Over 48 weeks: Subgroup Analyses from the Effisayil 2 Trial
Authors: Warren Richard , Burden David , Choon Siew Eng , Gordon Kenneth , Puig Lluis , Mostaghimi Arash , Kokolakis Georgios , Hu Na , Hofmann Patrick , Thoma Christian , Anadkat Milan 
Published: November 2023

Introduction: Generalized pustular psoriasis (GPP) is characterized by flares of widespread pustulation and erythema that may be fatal. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved to treat GPP flares. Effisayil 2 trial (NCT04399837) assessed efficacy and safety of spesolimab for prevention of GPP flares over 48 weeks. Here we show the efficacy of high-dose subcutaneous (SC) spesolimab for GPP flare prevention in prespecified subgroups in Effisayil 2.
Methods: Eligible patients were randomized 1:1:1:1 to receive placebo, or low- (300 mg loading dose [LD]; 150 mg every 12 weeks [q12w]), medium- (600 mg LD; 300 mg q12w) or high-dose (600 mg LD; 300 mg every 4 weeks) SC spesolimab over 48 weeks. We assessed the efficacy of high-dose spesolimab versus placebo across prespecified subgroups (including IL36RN mutation, comorbid plaque psoriasis [PsV], and body mass index [BMI] status) for the primary endpoint, time to first GPP flare by Week 48 (defined as a ≥2 GPPGA total score increase from baseline and ≥2 GPPGA pustulation score increase from baseline; subsequent use of rescue SC spesolimab also indicated a GPP flare), using a Cox regression analysis stratified by systemic use of GPP medications at randomization. Key secondary endpoint was proportion of patients with ≥1 GPP flare by Week 48.
Results: 123 patients were randomized (placebo, N=31; high-dose spesolimab, N=30). Hazard ratios (95% CI) for the primary endpoint favored high-dose spesolimab vs placebo in most prespecified subgroups, including: with IL36RN mutation, 0.04 (0.002, 1.152); without IL36RN mutation, 0.41 (0.109, 1.537); PsV absent at baseline, 0.14 (0.031, 0.629); PsV present at baseline, 0.22 (0.025, 1.883); and BMI <25 kg/m2, 0.22 (0.057, 0.816); 25 to <30 kg/m2, 0.12 (0.005, 2.817); and ≥30 kg/m2, 0.23 (0.008, 6.033). For the key secondary endpoint, adjusted risk differences (95% CI) by Week 48 were lower in those receiving high-dose spesolimab vs placebo in these prespecified subgroups: with IL36RN mutation, -0.75 (-1.000, -0.326); without IL36RN mutation, -0.22 (-0.504, 0.074); PsV absent at baseline, -0.41 (-0.672, -0.154); PsV present at baseline, -0.32 (-0.830, 0.191); and across all BMI subgroups.
Conclusion: Over 48 weeks, high-dose spesolimab was effective at preventing GPP flares irrespective of IL36RN mutation, comorbid PsV and BMI status at baseline.
Flare Frequency and Duration in Patients with Generalized Pustular Psoriasis (GPP)
Authors: Jullien Denis , Azura Affandi , Misery Laurent , Jyh Jong Tang , Turki Haminda , Muniandy Pubalan , Tan Wooi Chiang 
Published: November 2023

Introduction: Generalized pustular psoriasis (GPP) is a rare, neutrophilic, chronic skin disease in which an overactivation of inflammatory pathways causes widespread erythema and eruption of sterile pustules that may coalesce into ‘lakes of pus’. GPP flares are heterogeneous, and there is no standard clinical definition. GPP flares are painful; severe cases may require emergency treatment and can lead to life-threatening complications such as sepsis. The objective of this study was to characterize the frequency, number, and duration of flares in patients with GPP.
Methods: We conducted a retrospective chart review including patients of all ages with a confirmed diagnosis of GPP after 2011 receiving care at 27 sites in France, Malaysia, and Tunisia.
Results: Data from 175 patients were included (France: 58.9%, Malaysia: 31.4%, Tunisia: 9.7%). Mean (SD) follow-up was 5.0 (3.1) years. Flare-related care was the second most common reason for patient visits, accounting for 200 of 1378 follow-up visits after GPP diagnosis, surpassed only by routine follow-up. The mean (SD) annual number of flare episodes was 2.3 (2.0); the total number of flare episodes since the initial flare leading to diagnosis ranged from 0 to 9. Eighty-three (47.4%) patients experienced ≥1 flare episode after diagnosis, though individual country data suggested a higher flare burden in Tunisia (70.6%) and Malaysia (54.5%) versus France (39.8%). Twenty-eight patients (16.0%) had ≥2 flare episodes (60 visits); median (min, max) time between episodes was 11.6 (0.1, 52) months. The mean (SD) duration of flares was 34.3 (41.3) days during follow-up. Of 254 hospitalizations, 128 (50.4%) were flare-related inpatient admissions. Overall, 37.5% of GPP flares required inpatient care. The mean (SD) duration of flare-related admissions was almost twice as long as non-flare admissions at 19.2 (23.1) days versus 10.5 (8.1) days. Mean (SD) time between flare-related hospitalizations among 66 patients (128 hospitalizations) was 14.1 (17.1) months, with a median of 9.5 months indicating a skew distribution.
Conclusion: Flare episodes are a heavy burden for patients with GPP, with flares recurring as often as once a year and lasting up to 2 weeks or more. Flares account for >50% of hospitalizations for patients with GPP and are an important cause of follow-up care visits. The frequency of flares varied between patients, with some individuals experiencing up to 10 episodes over the study period. Heterogeneity of flares and rarity of GPP make diagnosis and clinical study challenging, while the severity of acute episodes and the burden of flare reoccurrence demonstrate the need for more effective treatment options.
Real-World Switch Rates for Patients With Psoriasis Initiating Risankizumab Stratified by Body Mass Index
Authors: Wu Jashin , Patel Manish , Photowala Huzefa , Li Chao , Armstrong April 
Published: November 2023

Introduction: Psoriasis (PsO) is a chronic, inflammatory skin disorder that affects 1%–4% of adults in the US. While PsO typically affects the skin, it is also associated with other systemic comorbidities, such as psoriatic arthritis, cardiometabolic disease, diabetes, and obesity. Switching therapies is common in patients with PsO due to poor treatment outcomes, such as lack of efficacy or safety/tolerability issues that are notably more pronounced in refractory patients. This study aims to quantify real-world switch rates for patients with PsO treated with risankizumab, stratified by body mass index (BMI) categories.
Methods: The Optum® Market Clarity data, which includes insurance claims linked with electronic medical records data, was used to identify biologic-naïve adult patients who initiated risankizumab between May 1, 2019 and September 30, 2022, with ≥1 PsO diagnosis (ICD codes) on or prior to biologic initiation. Patients had ≥6 months of continuous insurance benefits pre- and ≥12 months post-biologic initiation, and BMI data available on or in the 12 months before the start of risankizumab. Assessed outcomes included switch rates over 12 months among all risankizumab initiators and stratified by BMI category (BMI <25 Kg/m2, 25 to <30 Kg/m2, ≥30 Kg/m2).
Results: A total of 367 patients were included in this analysis. The mean (SD) age of patients was 47.7 (14.3) years, 194 (52.9%) were female, 20 (5.5%) were Black, and 305 (83.1%) were White. Of all patients, 71 (19.4%) had a BMI of <25 Kg/m2, 111 (30.2%) had a BMI of 25 to <30 Kg/m2, and 185 (50.4%) had a BMI ≥30 Kg/m2. The switch rate by 12 months for all patients initiating risankizumab was 3.8%. Switch rates by BMI category were 5.6% (BMI <25 Kg/m2), 2.7% (BMI 25 to <30 Kg/m2), and 3.8% (BMI ≥30 Kg/m2); there were no significant differences in switch rates between BMI categories (P = 0.589 from Fisher's exact test).
Conclusions: In this real-world study, treatment patterns through 12 months among patients initiating risankizumab were consistent regardless of BMI category.
Aesthetic Efficacy of a Novel Topical Combination Brightening Regimen to Treat Facial Hyperpigmentation
Authors: Goberdhan Lisa , Schneider Katie , Bautista Arielle , Makino Elizabeth , Mehta Rahul 
Published: November 2023

Purpose: Hyperpigmentation is a multifaceted condition that is often challenging to treat. Due to this complexity, a combination therapy providing a holistic approach of removal and prevention of pigmentation has shown greater efficacy than a monotherapy treatment. A clinical usage study was conducted to assess the cosmetic changes of a combination take-home skincare topical regimen of a novel brightening platform in subjects with mild to severe facial hyperpigmentation.
Procedure: Participants received a take-home multimodal brightening skincare regimen (EC Regimen) that consisted of twice-daily use of EC brightening Pads and EC serum, and once-daily evening use of EC spot cream. Clinical Efficacy and tolerability assessments, and participant self-assessments of facial skin appearance were conducted.
Results: Nineteen participants aged 31-69 years, with Fitzpatrick Skin Types I-IV, who self-identified their ethnicity as Asian, White, American Indian, and Hispanic, were included in the study. The EC Regimen provided statistically significant improvements as early as week 1 in Dark Spot Severity and Dark Spot Contrast grades with continued significant improvements through week 12 versus baseline (p<0.01). There were significant improvements in Overall Hyperpigmentation and the validated Modified Melasma Area and Severity Index scores as early as week 2 with continued significant improvements through week 12 versus baseline (p<0.03). Additionally, improvements in a variety of photoaging concerns such as Overall Photodamage, Tactile Roughness, Skin Tone Evenness, Fine and Coarse Lines/Wrinkles and Radiance were observed at all time points.
The EC Regimen was highly rated by participants with an overall satisfaction of 94% by week 12. At week 12, participants stated that EC Regimen “faded the dark spots that I have had for more than 5 years” (89%), “helped prevent new dark spots” (94%), and “improved my most stubborn spots that bother me the most” (89%). At week 12, EC Regimen improved quality-of-life parameters and participants stated that EC Regimen “makes me feel happier with how I look” (83%) and “makes me more confident” (83%). EC Regimen was well-tolerated as tolerability assessments remained mild for the duration of the study.
Conclusions: Combination therapy of EC Regimen provides a well-tolerated, effective treatment for multiple hyperpigmentation and photoaging parameters with high patient satisfaction.
PREVALENCE OF PLASMID MEDIATED QNRA, QNRB AND QNRS AMONG CLINICAL ESCHERICHIA COLI ISOLATED FROM URINARY TRACT INFECTIONS IN DUHOK, KURDISTAN REGION OF IRAQ
Authors: Ibrahim Delveen R. 
Published: November 2023

Excessive use of antibiotics (such as fluoroquinolone) and inadequate infection control practices have turned antibiotics resistance (AMR) into a global, public health peril. The current study emphasizes on the prevalence of qnrA, qnrB, and qnrS plasmid in fluroquinolone (FQ) resistant Escherichia coli (E. coli) isolates from urinary tract samples and their correlation with the burden of resistance in these isolates. In this research, several E. coli strains were isolated from outpatients having urinary tract infections (UTIs) from Duhok province, Kurdistan Region of Iraq. Biochemical and Molecular confirmations were performed to confirm the isolates. Antibiotics susceptibility test was performed to detect the isolates antibiogram. Furthermore, polymerase chain reaction (PCR) amplification was used to detect the qnrA, B and S genes. Bioinformatics tools were used to perform the analysis of the results and data visualization. Forty isolates (out of 55) have been confirmed as E. coli. Antibiograms revealed that 70%, 65% and 63% of the isolates were resistant to Ciprofloxacin, Enrofloxacin and Levofloxacin, respectively. While there was variation in resistance to other antibiotics tested. The FQ resistant genes were detected in 17 (42.5%) isolates, with some isolates carrying more than one gene. The variant qnrS was the most predominant, as it has been detected in 14 isolates. The increasing rates of multidrug resistance E. coli isolates from UTIs, including FQ antibiotics, emphasizes the importance of carefully monitoring their use for UTI treatment.
Première grossesse avec succès en dialyse péritonéale à La Réunion
Authors: Aizel Ali , Omarjee Asma , Hebmann Delphine 
Published: November 2023

Nous rapportons la première grossesse menée avec succès en dialyse péritonéale (DP), en 2023, dans les territoires et départements outre-mer (DOM-TOM) de France, à la REUNION, chez une femme de 34 ans, infirmière de profession. Elle été traitée par dialyse péritonéale continue ambulatoire (DPCA) depuis février 2022. La néphropathie d’origine était un syndrome d’Alport.
La grossesse a débuté vingt mois après le début de la dialyse. La patiente a souhaité poursuivre sa grossesse en DPCA afin d’effectuer les échanges durant la journée à son cabinet pour être plus disponible en famille le soir.
Le premier trimestre de la grossesse a été sans évènement particulier. Durant cette période la patiente a été informée des risques de la grossesse et nous avons défini ensemble nos objectifs avec les moyens disponibles. Les prescriptions médicamenteuses adjuvantes (calcium, aspirine, fer, acide folique, vitamine D..) ont été adaptées au cours du deuxième trimestre ainsi que le protocole de DP en suivant certains objectifs définis. Le troisième trimestre a nécessité une prise en charge en grande partie hospitalière
Les volumes d’infusion ont été progressivement diminués conjointement à une augmentation de leur fréquence qui a permis d’augmenter le volume quotidien total de dialyse. Elle a conservé une fonction rénale résiduelle stable pendant tout la durée de la grossesse et le taux d’urée plasmatique a pu être maintenu inférieur à 20 mmol/L
L’accouchement a été réalisé par césarienne sous rachianesthésie à 33 semaines et 4 jours d’aménorrhée avec naissance d’un garçon de 1800g dont le coefficient d’Apgar était de 5 à 1min, de 8 à 3min et de 9 à 5min. Le développement du bébé, et sa croissance ont été très satisfaisants.
Le respects des choix de la patiente, son autonomie et sa participation au traitement ont été des facteurs déterminants de réussite.
RAHASIA DI BALIK KESUKSESAN DALAM MEMPERTAHANKAN EKSISTENSI ANEKA OLAHAN BANDENG
Authors: Hapsari Aqilah Cindy , Mulyantomo Edy , Triyani Dian 
Published: November 2023

<p>Di Indonesia terkenal dengan berbagai kearifan lokal. Mulai dari budaya, bahasa, wisata, bahkan makanannya. Indonesia kaya akan hal tersebut, mengingat bahwa negara ini merupakan negara besar. Kearifan lokal yang dapat di temui pun cukup banyak, dan tersebar diberbagai wilayah. Terdapat makanan yang cukup terkenal, dan dapat di jumpai di Kabupaten Pati, Desa Raci. Kabupaten Pati terletak di Provinsi Jawa Tengah. Salah satu makanan atau oleh-oleh yang sangat diminati masyarakat sekitar bahkan luar daerah yang ada di Desa Raci yang cukup terkenal adalah “Aneka Olahan Bandeng”. Penelitian ini dilakukan pada usaha olahan Bandeng Berkah, yang sudah bertahan selama bertahun-tahun didesa Raci, Kabupaten Pati. Penelitian ini dilakukan dengan tujuan untuk mengetahui apa saja hal yang dilakukan usaha ini sehingga masih bisa bertahan hingga sekarang dan masih digemari oleh para pecinta kuliner dan bisa berhasil hingga saat ini. Penelitian ini menggunakan metode penelitian kualitatif dengan menggunakan analisis data triangulasi sumber serta triangulasi teknik. Teknik pengumpulan data yang digunakan yaitu melalui teknik wawancara mendalam, observasi dan dokumentasi. Pemilihan informan didasarkan pada kebutuhan penelitian. Dalam penelitian ini terdapat 5 informan yang terdiri dari informan kunci, informan utama serta informan pendukung, sebab jumlah <em>sample</em> sudah mencukupi. Hasil penelitian menunjukkan bahwa pada usaha aneka olahan Bandeng Berkah ini terdapat beberapa faktor yang membuat usaha ini masih bertahan dan sukses hingga saat ini yaitu dari segi kualitas produk, kualitas bahan baku, kualitas pelayanan yang baik, harga yang terjangkau, produksi yang baik, serta rasa yang tetap dan tidak berubah-ubah.</p>
ANALISIS GAYA HIDUP SEBAGAI VARIABEL MEDIASI PADA PERILAKU KONSUMTIF BELANJA ONLINE
Authors: Widiastuti C Tri , Universari Nuria , Setiawan Irene Nathalia 
Published: November 2023

Kemajuan teknologi informasi telah mempengaruhi perubahan kebiasaan belanja masyarakat, beralih dari belanja tradisional ke online. Pergeseran perilaku belanja berdampak pada semua generasi, termasuk Generasi Z dan akan menjadi konsumen terbesar dalam waktu dekat. Generasi Z berperilaku berbeda dibandingkan generasi sebelumnya, Generasi Z gemar melakukan belanja online. Penelitian ini bertujuan untuk menganalisis pengaruh literasi keuangan terhadap perilaku konsumtif belanja online yang dimediasi gaya hidup. Populasi penelitian generasi Z di kota Semarang. Sampel penelitian Generasi Z pada rentang usia 18-24 tahun atau generasi yang berada pada tingkat perguruan tinggi dengan status mahasiswa, menggunakan Instagram sebanyak 102 responden. Data dikumpulkan melalui kuesioner dan dianalisis menggunakan skala likert. Analisis data menggunakan <em>Partial Least Square</em>s (PLS) dengan aplikasi SmartPLS 3.0. Hasil penelitian menunjukkan bahwa 1) literasi keuangan berpengaruh positif terhadap perilaku belanja online. Literasi keuangan memiliki dampak besar pada kebiasaan pembelian online, memahami literasi keuangan dapat membantu generasi Z menghindari pengeluaran berlebihan. 2) gaya hidup berpengaruh positif terhadap perilaku belanja online konsumtif. Gaya hidup hedonis sebagai sarana untuk memuaskan keinginan dan keinginannya secara instan, generasi ini tergoda melakukan pembelian impulsif karena strategi pemasaran yang menawarkan pengalaman baru 3) literasi keuangan berpengaruh positif terhadap gaya hidup hedonis. Dengan literasi keuangan yang baik dapat membantu generasi ini untuk tidak terpengaruh belanja barang yang tidak dibutuhkan, dan 4) gaya hidup hedonis dapat memediasi literasi keuangan pada perilaku belanja online yang konsumtif. Sangat penting bagi Generasi Z memiliki financial literacy agar dapat mengetahui dampak dari gaya hidup dan perilaku konsumtif Generasi Z terhadap keuangan pribadi
SAR Change Detection Algorithm Combined with FFDNet Spatial Denoising
Authors: Wu Yuqing , Xu Qing , Zhang Zheng , Ma Jingzhen , Zhao Tianming , Zhu Xinming 
Published: November 2023

Objectives: When detecting changes in synthetic aperture radar (SAR) images, the quality of the difference map has an important impact on the detection results, and the speckle noise in the image interferes with the extraction of change information. In order to improve the detection accuracy of SAR image change detection and improve the quality of the difference map, this paper proposes a method that combines the popular deep neural network with the clustering algorithm.Methods: Firstly, the SAR image with speckle noise was constructed, and the FFDNet architecture was used to retrain the SAR image, and the network parameters with better effect on speckle noise suppression were obtained. Then the log ratio operator is generated by using the reconstructed image output from the network. Finally, K-means and FCM clustering algorithms are used to analyze the difference images, and the binary map of change detection results is generated. Results: The experimental results have high detection accuracy on Bern and Sulzberger's real data, which proves the effectiveness of the method.
Penyuluhan Pemanfaatan Media Sosial dalam Pemasaran Tenun Sutera bagi Siswa SMA dan SMK di Kabupaten Garut
Authors: Susanti Santi 
Published: November 2023

Tenun sutera merupakan salah satu hasil kearifan lokal masyarakat Garut yang telah dikenal secara nasional dan internasional. Namun, keberadaan tenun sutera ternyata kurang dikenal oleh masyarakat Garut. Mereka lebih mengenal batik sebagai salah satu identitas Kabupaten Garut. Untuk mengenalkan tenun sutera sekaligus pemasarannya, maka tim Pengabdian kepada Masyarakat (PPM) Universitas Padjadjaran mengadakan penyuluhan mengenai Pemanfaatan Media Sosial dalam Pemasaran Tenun Sutera bagi Siswa SMA dan SMK di Kabupaten Garut. Kegiatan diselenggarakan pada 26 Januari 2023, di Aula Kantor Kecamatan Tarogong Kidul, Kabupaten Garut. Dihadiri oleh para siswa dan guru SMA/SMK di Kecamatan Tarogong Kidul. Metode pelaksanaan PPM ini adalah pendidikan masyarakat yang disampaikan dengan metode ceramah. Kegiatan pengabdian ini, berkontribusi dalam menambah wawasan peserta mengenai tenun sutera Garut dan cara pemasarannya. Penggunaan media sosial dalam promosi dan pemasaran produk tenun sutera Garut telah dilakukan oleh para pengusaha tenun yang menjadi narasumber dalam PPM ini. Penggunaan media sosial sangat membantu para pengusaha dalam promosi dan pemasaran tenun sutera Garut. Konsistensi untuk mengunggah konten serta inovasi dalam produk maupun dalam penggunaan media sosial berperan penting dalam mempromosikan dan memasarkan produk tenun sutera Garut lebih luas.

Silk weaving is one of the local wisdoms of Garut society that has been recognized nationally and internationally. However, Garut people are less aware of the existence of silk weaving. They are more familiar with batik as one of the typical products of Garut Regency. To introduce silk weaving and its marketing, the Padjadjaran University Community Service (PPM) team held a workshop about Social Media Utilization in Marketing Silk Weaving for High School and Vocational School Students in Garut Regency. The activity was held on January 26, 2023, at the Tarogong Kidul District Office Hall, Garut Regency. Attended by high school / vocational school students and teachers in Tarogong Kidul District. This PPM implementation community education delivered by the lecture method. This community service activity contributed to increase the participants' knowledge about Garut silk weaving and its marketing methods. Social media use is very helpful for entrepreneurs in the promotion and marketing of Garut silk weaving. This PPM concluded that the consistency of uploading content as well as product innovation and the use of social media play an important role in promoting and marketing Garut silk weaving products more extensive.
Penggunaan Metode Bercerita Berbasis Kearifan Lokal untuk Meningkatkan Karakter Tanggung Jawab Anak
Authors: Ulfah, S.Pd, M.Pd St. Maria , Asdar Asdar , Nurdiyah Nurdiyah 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui implementasi metode bercerita berbasis kearifan lokal untuk meningkatkan rasa tanggung jawab anak. Subjek penelitian adalah 15 anak dari kelompok B. Adapun pelaksanaan Penelitian ini yakni pada tahun ajaran 2021/2022. Pendekatan yang digunakan yaitu kualitatif dan menggunakan penelitian tindakan kelas. Teknik pengumpulan data melalui observasi dan dokumentasi. Fokus penelitian ini adalah meningkatkan rasa tanggung jawab anak melalui metode bercerita berbasis kearifan lokal. Data yang diperoleh dianalisis dengan deskriptif dan kualitatif, melalui observasi dan dokumentasi dianalisis dengan menggunakan analisis kualitatif untuk menggambarkan hasil penelitian. Hasil penelitian di TK Fathinah menunjukkan adanya peningkatan rasa tanggung jawab anak melalui penggunaan metode bercerita berbasis kearifan lokal, terlihat dari rata-rata hasil yang diperoleh pada siklus I yang dikategorikan kurang meningkat dan pada siklus II dikategorikan baik.