bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteogenic Effects of Bioactive Compounds Found in Fruits on Mesenchymal Stem Cells: A Review
Authors: Sodré Lia Igel , Gall Maria Eduarda Cordebello , Elias Monique de Barros , Oliveira Luana Oeby de , Lobo Francine Albernaz Teixeira Fonseca , Carias Rosana Bizon Vieira , Teodoro Anderson Junger 
Published: January 2025

Abstract
Phytochemicals, which are bioactive compounds contained in fruits, vegetables, and teas, have a positive effect on human health by having anti-inflammatory, antioxidant, and anticarcinogenic effects. Several studies have highlighted the ability of bioactive compounds to activate key cellular enzymes associated with important signaling pathways related to cell division and proliferation, as well as their role in inflammatory and immunological responses. Some phytochemicals are associated with increased proliferation, differentiation, and expression of markers related to osteogenesis, bone formation, and mineralization by activating various signaling pathways. The objective of this study was to clarify which bioactive compounds present in fruits have osteogenic effects on mesenchymal stem cells and the possible associated mechanisms. A literature search was conducted in the LILACS, MEDLINE, and PubMed databases for pertinent articles published between 2014 and 2024. This review included 34 articles that report the osteogenic effects of various bioactive compounds found in different fruits. All the articles reported that phytochemicals play a role in enhancing the regenerative properties of mesenchymal cells, such as proliferation, osteogenic differentiation, secretion of angiogenic factors, and extracellular matrix formation. This review highlights the potential of these phytochemicals in the prevention and treatment of bone diseases. However, more studies are recommended to identify and quantify the therapeutic dose of phytochemicals, investigate their mechanisms in humans, and ensure their safety and effectiveness for health, particularly for bone health.
Effects of Probiotics and Diet Management in Patients With Irritable Bowel Syndrome: A Systematic Review and Network Meta-analysis
Authors: Lei Yupeng , Sun Xuemei , Ruan Tiechao , Lu Wenting , Deng Bixin , Zhou Ruixi , Mu Dezhi 
Published: January 2025

Abstract

Context
The efficacy of probiotics and diet management in irritable bowel syndrome (IBS) is controversial, and their relative effectiveness remains unclear.

Objective
This study aimed to evaluate the effects of probiotics, diet management, and their combination on IBS.

Data Sources
PubMed, Embase, Cochrane, and Web of Science were searched from inception to July 10, 2023, for relevant studies, including symptom relief, IBS–symptom severity score (-SSS), and IBS–quality of life measure (-QOL).

Data Extraction
Two investigators independently performed the data extraction and quality assessment.

Data Analysis
A network meta-analysis was performed using a frequentist approach and a random-effects model to estimate the relative risk (RR) and 95% CI.

Results
Forty-four articles were eligible for this study. In relieving IBS symptoms, compared with a sham diet, a low–fermentable oligosaccharide, disaccharide, monosaccharide, and polyols (low-FODMAP) diet (RR: 3.22; 95% CI: 1.70–6.26) and low-FODMAP diet combined with probiotics (RR: 17.79; 95% CI: 3.27–112.54) significantly relieved IBS symptoms. The control group showed significantly lower effectiveness than the probiotics group (RR: 0.47; 95% CI: 0.32–0.69). According to the surface under the cumulative rank curve (SUCRA), a low-FODMAP diet combined with probiotics (80.4%) had the best effect in relieving IBS symptoms, followed by a low-FODMAP diet (70.8%), probiotics (65.1%), and a gluten-free diet (54.3%). In reducing the total IBS-SSS, the low-FODMAP diet (90.5%) was the most effective, followed by the low-FODMAP diet combined with probiotics (76.6%), probiotics alone (62.3%), and gluten-free diet (28.3%). In reducing total IBS-QOL, probiotics (72.1%) ranked first, followed by gluten-free (57.0%) and low-FODMAP (56.9%) diets. Probiotics (34.9%) were associated with the lowest risk of adverse effects.

Conclusion
A low-FODMAP diet combined with probiotics is most effective in relieving IBS symptoms. A low-FODMAP diet is the most recommended diet for alleviating IBS severity, and probiotics were associated with improving the QOL of patients with IBS, with the fewest adverse events.

Systematic Review Registration
PROSPERO registration no. CRD42024499113.
Better not to vote to restore democracy? Boycotting the 2023 national referendum as a manifestation of (anti)party identification: The case of Poles voting abroad
Authors: Musiał-Karg Magdalena , Kapsa Izabela 
Published: January 2025

Abstract
This article explores the attitudes of Poles living abroad who decided not to participate in the national referendum, even though they voted in simultaneously held parliamentary elections. Their abstention is viewed as a manifestation of their (anti) party identification. The ruling right-wing populist party had hoped that raising fears about immigrants, the retirement age, and the sale of Polish assets would boost support for the referendum and—consequently—parliamentary elections. However, this strategy backfired by mobilizing the party’s opponents, who boycotted the referendum in protest. Through quantitative analysis, we explore how the 2023 referendum deepened societal divisions fueled by polarization. We investigate the connection between voters’ decisions and their party affiliations. Using data from a sample of 1087 individuals, our analysis shows significant correlations between party identification and referendum abstention. The findings suggest that strong party allegiance can drive strategic nonparticipation, often as a form of protest or civil disobedience against opposing political forces.
Safety and health care utilization following COVID-19 vaccination (BNT162b2) among children and youth with juvenile idiopathic arthritis and inflammatory bowel disease: A population-based study
Authors: Lee Jennifer J Y , Bernatsky Sasha , Benchimol Eric I , Kwong Jeffrey C , Li Qing , Yeung Rae S M , Widdifield Jessica 
Published: January 2025

Abstract

Objectives
To evaluate among Ontario children and youth (&lt;16 years old) with juvenile idiopathic arthritis (JIA) or inflammatory bowel disease (IBD), whether COVID-19 vaccines (Monovalent BNT162b2) were associated with adverse events of special interest (AESI) or health care utilization.

Methods
Using health administrative databases, all children/youth with JIA or IBD who received at least one vaccine were identified from November 2020 to December 2021 with follow-up until August 31, 2022. Self-controlled case series analyses were used to determine the relative incidence rates (RIR) of events in any 3-week period [AESI, Emergency Department (ED) visits, hospitalizations] and in any 1-month period [specialist visits] post-vaccine compared to control periods.

Results
We studied 1629 JIA and 1050 IBD patients. In the JIA cohort, the median age at vaccination was 12.0 years [Interquartile range (IQR): 10.0 to 14.0], and the median disease duration was 4.3 years (IQR: 2.0 to 7.5). By December 2021, 67.1% (n = 1093) received two doses and 24.1% (n = 393) received three doses. In the IBD cohort, the median age at vaccination was 13.0 (IQR: 11.0 to 14.0) with a median disease duration of 2.4 years (IQR: 1.1 to 4.8). Fifty-four percent (n = 565) received two doses and 36.3% (n = 381) received three doses. During risk periods, AESI was rarely reported. Relative to control periods, JIA and IBD patients demonstrated similar rates of hospitalizations [JIA: RIR: 0.76 (95% confidence interval [CI]: 0.25 to 2.33), IBD: RIR: 0.64 (95% CI: 0.29 to 1.41)], ED visits [JIA: RIR: 1.11 (95% CI: 0.77 to 1.59), IBD: RIR: 0.93 (95% CI: 0.61 to 1.43)], and specialist visits [JIA: RIR: 1.06 (95% CI: 0.89 to 1.26), IBD: RIR: 0.56 (95% CI: 0.22 to 1.43)].

Conclusions
Overall, this study demonstrates the safety of the BNT162b2 vaccine in children/youths with JIA and IBD, with no associated increase in AESI or health care use.
Development of START, a novel multimedia-based symptom appraisal tool for autoimmune rheumatic diseases
Authors: Xiang Ling , Low Andrea H L , Leung Ying Ying , Fong Warren , Lau Tang Ching , Koh Dow Rhoon , Yoon Sungwon , Thumboo Julian 
Published: January 2025

Abstract

Objectives
To facilitate earlier diagnosis of autoimmune rheumatic diseases (ARDs), we aimed to (i) develop Symptom Testing for Autoimmune RheumaTic diseases (START), a novel multimedia-based symptom appraisal tool for ARDs and (ii) pilot test START among established ARD cases and non-ARD controls.

Methods
We developed START using a social cognitive theory–based theoretical framework and consensus-based lists of ARDs and manifestations from our previous work. START was revised through reviews by an expert panel of rheumatologists and cognitive debriefing interviews (CDIs) with patients newly referred for assessment of ARDs. We pilot tested START to evaluate its sensitivity, specificity and test–retest reliability in detecting patients with known ARDs.

Results
Of the 59 manifestations of ARDs identified from our previous work, 33 reached expert consensus for content validity, 26 were removed because they were non-specific or late features of ARDs. Similar manifestations were grouped, resulting in 19 items. The phrasing and formatting of items in START were revised based on findings from the CDIs with 36 patients and expert panel review. Visual illustrations such as photos and drawings were included to improve comprehension of items in START, using an online platform for implementation. Pilot testing in 145 patients with ARDs, 133 patients with non-ARDs and 155 healthy controls found that the sensitivity, specificity and test–retest reliability in detecting patients with any ARDs were 86.2%, 80.9% and 0.789, respectively.

Conclusion
A novel multimedia-based symptom appraisal tool for ARDs was developed, which addresses the limitations of existing tools and exhibited promising sensitivity and specificity in detecting patients with known ARDs.
Imaging tests as predictors of progression to rheumatoid arthritis in clinically suspect arthralgia: a systematic review and meta-analysis
Authors: Gupta Ankita , Anis Sulaiman , de Pablo Paola 
Published: January 2025

Abstract

Objectives
To determine and compare the diagnostic accuracy of imaging tests for the prediction of RA progression in people with inflammatory joint pain or clinically suspect arthralgia (CSA).

Methods
We searched MEDLINE, Embase and Web of Science from 1987 to March 2024. Studies evaluating any imaging tests in participants with inflammatory joint pain or CSA without clinical synovitis were eligible. Reference standards included RA classification criteria, methotrexate initiation or development of inflammatory arthritis (IA). Two authors independently extracted data and assessed validity according to QUADAS-2. We estimated summary sensitivities and specificities for each imaging characteristic and fitted bivariate and hierarchical SROC models for meta-analysis where possible.

Results
We found 39 eligible studies including 42 cohorts, of which 12 evaluated MRI (n = 2782; 19% with RA/IA), 26 evaluated ultrasound (US) (n = 6805; 25% with RA/IA) and 10 evaluated other imaging tests (n = 3362; 20% with RA/IA). Summary sensitivity and specificity for US Power Doppler ≥1 in at least one joint were 37% (95%CI 18%–60%) and 90% (95%CI 82%–94%), respectively (seven studies). Summary sensitivity and specificity for MRI synovitis in at least one joint were 45% (95%CI 29%–62%) and 84% (95%CI 66%–94%), respectively (four studies). Lack of consensus regarding positive threshold definitions limited meta-analysis for other imaging features.

Conclusion
Evidence for MRI or US in predicting RA/IA in people with CSA is heterogeneous and of variable quality. Further studies with larger sample sizes, longer follow-up times and uniform imaging test scoring are warranted to determine whether imaging characteristics, in combination with clinical information, can predict RA in this population.

Systematic review registration
PROSPERO: https://www.crd.york.ac.uk/prospero, CRD42024501243
Predictive value of insulin resistance metabolic score for cardiovascular disease in Chinese arthritis patients: a prospective cohort study
Authors: Ke Wen-kai , Xu Ling-ling , Luo Ni 
Published: January 2025

Abstract

Objectives
Although patients with arthritis have significantly increased cardiovascular disease (CVD) risk, effective prediction tools remain limited. This study aimed to evaluate the predictive value of the Metabolic Score for Insulin Resistance (METS-IR) for CVD events among Chinese patients with arthritis.

Methods
Using data from the China Health and Retirement Longitudinal Study (CHARLS), we conducted a 7-year prospective cohort study (2011–2018) involving 1,059 patients with arthritis. The primary exposure was baseline METS-IR, and the primary outcome was incident CVD. Multivariate Cox regression models were used to analyze the association between METS-IR and CVD risk, adjusting for demographic characteristics and lifestyle factors.

Results
After adjusting for confounding factors, each quartile increase in METS-IR was associated with a 36% increased risk of CVD (HR = 1.36,95%CI : 1.14–1.61, p&lt; 0.001). Compared with the lowest quartile, the highest quartile showed a 63% increased risk (HR = 1.63,95%CI : 1.12–2.37, p&lt; 0.05), demonstrating a significant dose-response relationship (p for trend &lt; 0.05).

Conclusion
METS-IR serves as an effective tool for predicting CVD risk among Chinese patients with arthritis, providing new strategies for early risk identification and prevention.
Efficacy and safety of first-line targeted synthetic DMARDs in rheumatoid arthritis patients with chronic kidney disease
Authors: Yoshimura Yusuke , Yamanouchi Masayuki , Koizumi Ryo , Mizuno Hiroki , Oba Yuki , Kurihara Shigekazu , Suwabe Tatsuya , Tsunoda Susumu , Kishioka Ayumi , Takeuchi Toshihiro , Tanimizu Hikaru , Kamido Hisashi , Yoshimoto Masatoshi , Sugimoto Hisashi , Ikuma Daisuke , Tanaka Kiho , Inoue Noriko , Sekine Akinari , Hasegawa Eiko , Wada Takehiko , Ubara Yoshifumi , Sawa Naoki 
Published: January 2025

Abstract

Objectives
To evaluate the efficacy and safety of first-line targeted synthetic disease-modifying anti-rheumatic drugs (tsDMARDs) in patients with rheumatoid arthritis (RA) and chronic kidney disease (CKD).

Methods
This retrospective cohort study included 216 patients with RA prescribed their first tsDMARDs at two hospitals between 2013 and 2022. Dose reduction and contraindication guidelines for tsDMARDs according to kidney function were followed. The patients were categorised by kidney function and tsDMARD modality. The primary outcome was the 24-month drug retention rate, and the secondary outcomes were changes in the Disease Activity Score 28-C-reactive protein (DAS28-CRP) level, prednisolone dosage, and reasons for discontinuation.

Results
The 24-month drug retention rates according to the estimated glomerular filtration rate (eGFR) (≥60, 30–60, or &lt; 30 mL/min/1.73 m2) were as follows: all tsDMARDs (46.0, 44.1, 47.1%), tofacitinib (55.9, 53.3, 66.7%), baricitinib (64.2, 42.0%), and peficitinib (36.4, 44.1, 40.0%). Even in groups with lower kidney function, the drug retention rate was maintained (adjusted hazard ratio was 1.14 (95% confidence interval, 0.81–1.62), p= 0.45). Patients had a decreased DAS28-CRP (p&lt; 0.01) and a reduced prednisolone dosage (p&lt; 0.01) over the six-month period following tsDMARD initiation. The incidence of herpes zoster and deep vein thrombosis (DVT) was higher in the group with an eGFR &lt;30 mL/min/1.73 m2, but not statistically significant.

Conclusions
tsDMARDs have demonstrated efficacy and safety in patients with RA and CKD; however, clinicians should consider the potential for herpes zoster and DVT in patients with eGFR &lt;30 mL/min/1.73 m2.
Sick Houses: Towards a Transnational History of Housing Hygiene Surveys, 1889–1913
Authors: Strunz Stephan 
Published: January 2025

Summary
Between 1889 and 1913, housing took centre stage in hygiene enquiries. Countless surveys across Europe sought to identify specific housing problems as health hazards. This paper explores the art of housing hygiene surveys in Belgium, France and Germany. Scrutinising surveys from Berlin, Liège and Paris, I characterise two contesting survey methods. On one hand, large-scale statistical surveys such as the sanitary register of houses in Paris aimed to establish robust epidemiological evidence on the connection between structural elements (like lighting and ventilation) and tuberculosis. On the other hand, monographic surveys adopted more idiosyncratic approaches, probing the relationship of housing and health from architectural, economic, hygienic and social angles, without insisting on a single vector of explanation. Although the era of monographic housing surveys was short-lived, it illuminates the complexity of housing as an epistemic object, which even today proves challenging to assess from a public health standpoint.
Efficient and Rapid Generation of Neural Stem Cells by Direct Conversion Fibroblasts with Single microRNAs
Authors: Li Yuanyuan , Sun Jing , Xu Tingting , Dai Bo , Wang Yuesi 
Published: January 2025

Abstract
Neural stem cells (NSCs) have great potentials in the application of neurodegenerative disease therapy, drug screening, and disease modeling. However, current approaches for induced NSCs (iNSCs) generation from somatic cells are still slow and inefficient. Here we establish a rapid and efficient method of iNSCs generation from human and mouse fibroblasts by single microRNAs (miR-302a). These iNSCs exhibited morphological, molecular and functional properties resembling those of adult human and mouse NSCs, and human iNSCs can be expanded for more than 20 passages in vitro. Furthermore, miR-302a alone was demonstrated to be sufficient to reprogram both human and mouse fibroblasts into iNSCs. Our results showed that direct conversion of autologous fibroblasts with miR-302a into iNSCs, which provides a rapid and efficient strategy to generate iNSCs for both basic research and clinical applications.
Potential of accelerometers to remotely early detect bovine ephemeral fever in cattle using pattern mining
Authors: Trieu Ly Ly , Bailey Derek W , Cao Huiping , Son Tran Cao , Macor Justin , Trotter Mark G , O’Connor Lauren , Tobin Colin T 
Published: January 2025

Abstract
Bovine Ephemeral Fever (BEF), caused by an arthropod-borne rhabdovirus, is widespread in tropical and subtropical regions. It affects cattle with symptoms of fever, lameness, inappetence and in some situations can result in mortality. The goal of this study is to determine if accelerometer data can be used to identify the behavior patterns that occur when cattle become ill from BEF. Eight heifers in a separate experiment were monitored with 3-axis accelerometers sensors. Movement variation (MV) was calculated from accelerometer data (25 Hz) using 1-min epochs and then averaged hourly. Two different approaches, cosine similarity (CS) and deviation from previous behavioral patterns, were developed to autonomously detect patterns and recognize the onset of sickness in cattle using accelerometer data. Analyses show that one heifer had behavioral changes one day before the manager observed BEF, and another heifer had behavioral changes on the same day the manager observed BEF. The other six heifers did not display any BEF symptoms. To validate the efficacy of our analytical approaches, we employed them on a separate commercial herd of 73 cows where 4 of the 27 monitored cows were observed with BEF symptoms. Predictions were either on the day or even the day prior to the manager’s observation and diagnosis. There were likely no false positives in the first or second trials using the deviation algorithm with sum_deviation formula, but there were several false positives with the other algorithms. These case studies demonstrate the potential of accelerometer data to autonomously detect disease onset, in some cases before it was apparent to the human observer. However, more research is needed to minimize false positives that may occur from other similar diseases, abnormal weather events or cyclical changes in behavior such as estrus is required.
A systematic review on health risks of water pollutants: classification, effects and innovative solutions for conservation
Authors: Shekhar Chander , Khosya Reetu , Sharma Arvind Kumar , Thakur Kushal , Mahajan Danish , Kumar Rakesh , Kumar Sunil , Sharma Amit Kumar 
Published: January 2025

Abstract
In this developing era, increased anthropogenic activities result in the contamination of natural resources. Different kinds of pollutants threaten the water quality being crucial for the existence of life. There are different sources and routes through which different kinds of pollutants cause health consequences. This systematic review consists of the classification of water pollutants and a particular focus on toxicological studies on aquatic life, soil, plants and humans with a comparative account of conservation technologies. In this study, various databases like Scopus, Science Direct, Google Scholar, Research Gate and Web of Science were used to find the most relevant and recent literature till September 2024. Studies were selected based on their focus on classes of water pollutants, routes, their cumulative effects and remediation technologies. This review successfully managed to classify the different water pollutants and found a significant association between their exposure and disorders shown by aquatic life and human health. There is a number of evidence of neurological disorders, reproductive and endocrine disruptions. However, the effect can also be seen in both aquatic as well as terrestrial ecosystems. Long-term exposure to water pollutants presents significant health risks and indicates degrading quality of drinking water and aquatic life. This review provides insight into the emergence of pollutants in water and the need for strong preventive policies. It also suggests the necessity of developing cost-effective and advanced conservation technologies for the availability of safe water.
Bridge employment in middle vs. late life for men and women: gendered social roles or life structures?
Authors: Aksaray Gorkem , Marcus Justin 
Published: January 2025

Abstract
Utilizing longitudinal data from a stratified random sample of 15,433 retirees from Turkey, a country with uniquely large variation in postretirement work years, our study is the first to examine the phenomenology of middle vs. late life in postretirement work and demographic intersectionality in retirement. Synthesizing theory in the vocational psychology of retirement with industrial sociology of the life course, the social forces approach we advocate helps shed light on whether documented sex differences in bridge employment participation are caused by social bias or life structure. Results suggest that family and work contexts affecting the gender gap in bridge employment participation may be explained by differing communal and work factors inherent at the intersection of sex and age, and that life stage interacts with social and work opportunity structures very differently for men and women. Yet a nuanced look also points to some trends suggesting a social bias explanation.