bluuebunny/crossref_metadata_2025_split huggingface dataset:
The DNA-repair protein APE1 participates with hnRNPA2B1 to motif-enriched and prognostic miRNA secretion
Authors: Mangiapane Giovanna , Notarangelo Michela , Canarutto Giulia , Fabbiano Fabrizio , Dalla Emiliano , Degrassi Monica , Antoniali Giulia , Gualandi Nicolò , De Sanctis Veronica , Piazza Silvano , D’Agostino Vito Giuseppe , Tell Gianluca 
Published: February 2024

ABSTRACTThe base excision repair (BER) Apurinic/apyrimidinic endonuclease 1 (APE1) enzyme is endowed with several non-repair activities including miRNAs processing. APE1 is overexpressed in many cancers but its causal role in the tumorigenic processes is largely unknown. We recently described that APE1 can be actively secreted by mammalian cells through exosomes. However, APE1 role in EVs or exosomes is still unknown, especially regarding a putative regulatory function on small non-coding RNAs vesicular secretion. Through dedicated transcriptomic analysis on cellular and vesicular small RNAs of different APE1-depleted cancer cell lines, we found that miRNAs loading into EVs is a regulated process, dependent on APE1, distinctly conveying RNA subsets into vesicles. We identified APE1-dependent secreted miRNAs characterized by enriched sequence motifs and possible binding sites for APE1. In 33 out of 34 APE1-dependent-miRNA precursors, we surprisingly found EXO-motifs and proved that APE1 cooperates with hnRNPA2B1 for the EV-sorting of a subset of miRNAs, including miR-1246, through direct binding to GGAG stretches. Using TCGA-datasets, we showed that these miRNAs identify a signature with high prognostic significance in cancer. In summary, we provided evidence that APE1 is part of the protein cargo of secreted EVs, suggesting a novel post-transcriptional role for this ubiquitous DNA-repair enzyme that could explain its role in cancer progression.
Targeting Heterochromatin Eliminates Chronic Myelomonocytic Leukemia Malignant Stem Cells Through Reactivation of Retroelements and Innate Immune pathways
Authors: Hidaoui Donia , Porquet Audrey , Chelbi Rabie , Bohm Mathieu , Polyzou Aikaterini , Alcazer Vincent , Depil Stéphane , Imanci Aygun , Morabito Margot , Renneville Aline , Sélimoglu-Buet Dorothée , Thépot Sylvain , Itzykson Raphael , Laplane Lucie , Droin Nathalie , Trompouki Eirini , Elvira-Matelot Emilie , Solary Eric , Porteu Françoise 
Published: February 2024

AbstractChronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate the malignant clone. Hematopoietic stem cell (HSC) aging involves heterochromatin reorganization, evidenced by alterations in histone marks H3K9me2 and H3K9me3. These repressive marks together with DNA methylation are essential for suppressing transposable elements (TEs). In solid cancers, the antitumor efficacy of HMAs involves the derepression of TEs, mimicking a state of viral infection. In this study, we demonstrate a significant disorganization of heterochromatin in CMML HSCs and progenitors (HSPCs) characterized by an increase in the repressive mark H3K9me2, mainly at the level of TEs, and a repression of immune and age-associated transcripts. Combining HMAs with G9A/GLP H3K9me2 methyltransferase inhibitors reactivates these pathways, selectively targeting mutated cells while preserving wild-type HSCs, thus offering new therapeutic avenues for this severe myeloid malignancy.
Hexagons all the way down: Grid cells as a conformal isometric map of space
Authors: Schøyen Vemund , Bechkov Constantin , Pettersen Markus Borud , Hermansen Erik , Holzhausen Konstantin , Malthe-Sørenssen Anders , Fyhn Marianne , Lepperød Mikkel Elle 
Published: February 2024

AbstractThe brain’s ability to navigate is often attributed to spatial cells in the hippocampus and entorhinal cortex. Grid cells, found in the entorhinal cortex, are known for their hexagonal spatial activity patterns and are traditionally believed to be the neural basis for path integration. However, recent studies have cast grid cells as a distance-preserving representation. We further investigate this role in a model of grid cells based on a superposition of plane waves. In a module of such grid cells, we optimise their phases to form a conformal isometry (CI) of two-dimensional flat space. With this setup, we demonstrate that a module of at least seven grid cells can achieve a CI, with phases forming a regular hexagonal arrangement. This pattern persists when increasing the number of cells, significantly diverging from a random uniform distribution. In particular, when optimised for CI, the phase distribution becomes distinctly regular and hexagonal, offering a clear experimentally testable prediction. Moreover, grid modules encoding a CI maintain constant energy expenditure across space, providing a new perspective on the role of energy constraints in normative models of grid cells. Finally, we investigate the minimum number of grid cells required for various spatial encoding tasks, including a unique representation of space, the population activity forming a torus, and achieving a CI, where we find that all three are achieved when the module encodes a CI. Our study not only underscores the versatility of grid cells beyond path integration but also highlights the importance of geometric principles in neural representations of space.
Semi-automated ontology development scheme via text mining of scientific records
Authors: Tamjid Somayeh , Nooshinfard Fatemeh , Hosseini Beheshti Molouk Sadat , Hariri Nadjla , Babalhavaeji Fahimeh 
Published: February 2024

Purpose
The purpose of this study is to develop a domain independent, cost-effective, time-saving and semi-automated ontology generation framework that could extract taxonomic concepts from unstructured text corpus. In the human disease domain, ontologies are found to be extremely useful for managing the diversity of technical expressions in favour of information retrieval objectives. The boundaries of these domains are expanding so fast that it is essential to continuously develop new ontologies or upgrade available ones.

Design/methodology/approach
This paper proposes a semi-automated approach that extracts entities/relations via text mining of scientific publications. Text mining-based ontology (TmbOnt)-named code is generated to assist a user in capturing, processing and establishing ontology elements. This code takes a pile of unstructured text files as input and projects them into high-valued entities or relations as output. As a semi-automated approach, a user supervises the process, filters meaningful predecessor/successor phrases and finalizes the demanded ontology-taxonomy. To verify the practical capabilities of the scheme, a case study was performed to drive glaucoma ontology-taxonomy. For this purpose, text files containing 10,000 records were collected from PubMed.

Findings
The proposed approach processed over 3.8 million tokenized terms of those records and yielded the resultant glaucoma ontology-taxonomy. Compared with two famous disease ontologies, TmbOnt-driven taxonomy demonstrated a 60%–100% coverage ratio against famous medical thesauruses and ontology taxonomies, such as Human Disease Ontology, Medical Subject Headings and National Cancer Institute Thesaurus, with an average of 70% additional terms recommended for ontology development.

Originality/value
According to the literature, the proposed scheme demonstrated novel capability in expanding the ontology-taxonomy structure with a semi-automated text mining approach, aiming for future fully-automated approaches.
Metaverse adoption: a systematic literature review and roadmap for future research
Authors: Dhingra Sanjay , Abhishek Abhishek 
Published: February 2024

Purpose
This study aims to explore and conceptualize metaverse adoption using a systematic literature review (SLR). It also aims to propose a conceptual model that identifies significant factors affecting metaverse adoption in the entertainment, education, tourism and health sectors.

Design/methodology/approach
A SLR was conducted using the “preferred reporting items for systematic reviews and meta-analyses” report protocol and the “theory, context, characteristics, methods” framework to include all relevant articles published up to March 2023, which were sourced from the Scopus and Web of Science databases.

Findings
The reviewed literature revealed that the countries with the highest publications in the field of metaverse were China and the USA. It was also found that the technology acceptance model was the most used theoretical framework. Survey-based research using purposive and convenience sampling techniques emerged as the predominant method for data collection, and partial least square-structural equation modeling was the most used analytical technique. The review also identified the top six journals and the variables that help to develop a proposed model.

Originality/value
This review presents a novel contribution to the literature on metaverse adoption by forming a conceptual model that incorporates the most used variables in the entertainment, education, tourism and health sectors. The possible directions for future research with identified research gaps were also discussed.
AI platform model on 4IR megatrend challenges: complex thinking by active and transformational learning
Authors: Sanabria-Z Jorge , Olivo Pamela Geraldine 
Published: February 2024

Purpose
The objective of this study is to propose a model for the implementation of a technological platform for participants to develop solutions to problems related to the Fourth Industrial Revolution (4IR) megatrends, and taking advantage of artificial intelligence (AI) to develop their complex thinking through co-creation work.

Design/methodology/approach
The development of the model is based on a combination of participatory action research and user-centered design (UCD) methodologies, seeking to ensure that the platform is user-oriented and based on the experiences of the authors. The model itself is structured around the active and transformational learning (ATL) framework.

Findings
This study highlights the importance of addressing 4IR megatrends in education to prepare students for a technology-driven world. The proposed model, based on ATL and supported by AI, integrates essential competencies for tackling challenges and generating innovative solutions. The integration of AI into the platform fosters personalized learning, collaboration and reflection and enhances creativity by offering new insights and tools, whereas UCD ensures alignment with user needs and expectations.

Originality/value
This research presents an innovative educational model that combines ATL with AI to foster complex thinking and co-creation of solutions to problems related to 4IR megatrends. Integrating ATL ensures engagement with real-world problems and critical thinking while AI provides personalized content, tutoring, data analysis and creative support. The collaborative platform encourages diverse perspectives and collective intelligence, benefiting other researchers to better conceive learner-centered platforms promoting 21st-century skills and co-creation.
Does mandatory expenditure on CSR affect firm value? Empirical evidence from Indian firms
Authors: Bhagawan Praveen , Mukhopadhyay Jyoti Prasad 
Published: February 2024

PurposeThe purpose of this study is to examine the impact of mandatory corporate social responsibility (CSR) spending on firm value in the Indian context.Design/methodology/approachUsing firm-level data over the period 2012–2017, this study uses the difference-in-differences (DID) technique combined with matching to control for potential endogeneity of the decision to comply with the CSR Act since the Act in its current form is applicable as a comply-or-explain obligation.FindingsThe results of this study suggest that mandatory CSR spending has a positive and statistically significant impact on firm value. These results remain robust to alternative econometric techniques such as regression discontinuity design (RDD) and randomization inference test as well as to alternative empirical specifications. Furthermore, the study demonstrates that the positive effect of CSR spending on firm value is more pronounced for firms with higher information asymmetry problem and lower institutional holdings.Originality/valueThis study explicitly considers the “comply-or-explain” flexibility option, in terms of spending on CSR, provided to Indian firms for the initial two to three years and investigates whether spending on CSR helps firms enhance their firm value. The study also finds that the positive effect of CSR spending on firm value is more pronounced for firms with higher information asymmetry problems and lower institutional holdings.
The living religious heritage of displaced communities: conservation problematics and use-related challenges
Authors: Sabri Reyhan , Sakallı Belgin 
Published: February 2024

PurposePlaces of worship have historically been maintained using traditional building management techniques, including regular monitoring, upkeep and maintenance provided by their religious communities. This paper examines the conservation issues arising after the forced displacement of the traditional custodians, which is a significant concern in conflict-ridden environments.Design/methodology/approachAs a unique example of a long-term conflict, the divided Cyprus provides this research with illustrative cases to derive the data. The research employs content analysis of official documents, physical observations and interviews with conservation professionals.FindingsThis research demonstrates the human and environmental factors impacting the conservation of the material fabric and the use-related challenges stemming from the intangible significance of the religious legacy belonging to displaced communities. It highlights the urgency to formulate more effective mechanisms and regulatory frameworks to address vulnerability issues promptly.Originality/valuePreservation problems on religious heritage buildings arising from the loss of traditional custodians after conflicts are an under-researched area in conservation literature. Drawing on research that was conducted several decades after the displacement of Cypriot communities, this paper reveals new insights into the magnitude of the conservation problems and the use-related complexities that need to be addressed to formulate mutually acceptable solutions for a sustainable future.
Envisioning sustainability through (un)shared professional visions of the “visual” materials of a design situation: a CCO approach
Authors: Reumont Marie , Cooren François , Déméné Claudia 
Published: February 2024

PurposeCommunicating a clear, precise, interpretable and unambiguous visual message usually relies on a cross-disciplinary team of professionals. Their complementary visions can uncover which information matter and how it could be visually displayed to inform, sensitize and encourage people to act toward sustainability. While design studies generally claim that this team has to come to a shared vision, the authors question this assumption, which seems to contradict the benefits of cross-disciplinarity. The purpose of this study is to reveal how simple visual representations displayed in a PowerPoint actively participate in the expression of various and sometimes divergent visions. Recognizing the agency of visuals also leads this study to propose the notion of (un)shared professional vision, which shows that the richness of visual representations can only reveal itself through the capacity of professional visions to maintain their differences while confronting each other.Design/methodology/approachOver a 20-month ethnography, this study documented its own cross-disciplinary reflective design process, which aimed to design collectively an experimental environmental label, focusing on interactions occurring between professionals and visuals displayed on five key PowerPoint slides.FindingsThis study first demonstrates how, in practice, a cross-disciplinary reflective design conversation with visuals concretely unfolds through boundary-objects. This study shows how these visuals manage to ex-press themselves through the multiple visions represented in the discussions, revealing their complexity. Second, this study introduces the notion of (un)shared professional vision which underlines that unsharing a vision nurtures the team’s collective capacity to express the complexity of a design situation, while sharing a vision is also necessary to confront these respective expressions to allow the professional uncovering of what should be visually communicated.Originality/valueThe Communication as Constitutive of Organization lens the authors chose to understand the reflective design conversation illustrates that, even though each collaborator’s vision was “(un)shared,” their many voices expand the understanding of the situation and lead them to develop an unexpected and creative environmental information ecosystem that can positively transform society through visuals.
One-to-one coaching and coachee personality trait change
Authors: Jones Rebecca J. , Woods Stephen A. 
Published: February 2024

Purpose A specific area of interest in the coaching literature is focused on exploring the intersection of personality and coaching; however, research has yet to explore whether coaching exerts reciprocal effects on personality traits (i.e. if personality trait change can accompany coaching). Utilizing the explanatory theoretical framing of the Demands-Affordances TrAnsactional framework (Woods et al., 2019), we propose that coaching may indirectly facilitate personality trait change by firstly enabling the coachee to reflect on their behaviors, second, implement desired behavioral changes which consequently facilitate personality trait change.Design/methodology/approachA quasi-experiment was conducted to explore coaching and personality trait change. Students participating in a demanding, work-based team simulation (N = 258), were assigned to either an intervention group (and received one-to-one coaching) or a control group (who received no intervention). Personality traits were measured before and after coaching and positioned as the dependent variable.FindingsResults indicate that participants in the coaching group exhibited significant changes in self-reported agreeableness, conscientiousness, extraversion and core self-evaluations, which all significantly decreased after coaching; however, no change was observed for the control group.Originality/valueWe provide the first exploration of coaching and personality trait change, contributing to both the coaching literature, by providing evidence regarding the efficacy of coaching to facilitate personality trait change in coachees, and the personality literature, by highlighting coaching as an important tool for those interested in personality trait change. Our research also has implications for other interventions such as mentoring, as we provide support for the notion that interventions can support personality trait change.
Untold stories of African American women entrepreneurs: research-based strategies for becoming one's own boss
Authors: Norman Joanna F. , Aiken Leah , Greer Tomika W. 
Published: February 2024

PurposeThe purpose of this research was to empirically examine the career transitions of mid-career African American women leaving traditional careers for entrepreneurship. The authors illustrate how transition theory and effectuation principles ameliorate an African American woman's transition to entrepreneurship.Design/methodology/approachThe authors conducted semi-structured interviews with nine African American woman entrepreneurs. The data collected were evaluated through the lens of transition theory and effectuation theory.FindingsThe study results show that despite being the chief officer, many African American women still face inequalities when negotiating business deals, interacting with partners and when seeking capital for their business. Effectuation theory partially supports an African American woman's career transition to entrepreneurship, but the theory does not fully address the unique experiences of this demographic.Research limitations/implicationsThe results of this study reveal that effectuation principles do not fully explain the entrepreneurial career transition experiences of African American women. Theory development and extensions of existing theories should consider the potential discriminatory practices that limit financial resources and strategic partnerships for African American women entrepreneurs. The authors also advocate for consideration of identities, particularly related to gender and race, as factors that contribute to entrepreneurial experiences.Practical implicationsThe study findings support the notion that each woman's situation will be different and unique, requiring aspiring African American woman entrepreneurs to assess their individual situation. Consistent access to minority-specific programs can help aspiring African American women entrepreneurs visualize her new identity and provide the support needed to enhance her career transition. There is no one-size-fits-all solution, so each woman will need to craft her own individualized plan.Social implicationsFindings from this study solidify the role of African American women entrepreneurs as business leaders with influence and direct impact on the US economy. Their success enables African American women to contribute to more inclusive societies through their service to diverse members of society. In addition, their attainment of success serves as a testimony to aspiring African American women that entrepreneurial success is achievable, encouraging more diversity in entrepreneurship.Originality/valueFew entrepreneurial studies exist on both women and racial minorities, resulting in a paucity of strategies to support African American women throughout their entrepreneurial journey. The results of this study revealed barriers which require specific strategies to address discriminatory lending practices and acceptance when forging new business relationships.