bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multisoliton interactions approximating the dynamics of breather solutions
Authors: Agafontsev Dmitry , Gelash Andrey , Randoux Stephane , Suret Pierre 
Published: December 2023

AbstractNowadays, breather solutions are generally accepted models of rogue waves. However, breathers exist on a finite background and therefore are not localized, while wavefields in nature can generally be considered as localized due to the limited sizes of physical domain. Hence, the theory of rogue waves needs to be supplemented with localized solutions, which evolve locally as breathers. In this paper, we present a universal method for constructing such solutions from exact multisoliton solutions, which consists in replacing the plane wave in the dressing construction of the breathers with a specific exact N‐soliton solution converging asymptotically to the plane wave at large number of solitons N. On the example of the Peregrine, Akhmediev, Kuznetsov–Ma, and Tajiri–Watanabe breathers, we show that constructed with our method multisoliton solutions, being localized in space with characteristic width proportional to N, are practically indistinguishable from the breathers in a wide region of space and time at large N. Our method makes it possible to build solitonic models with the same dynamical properties for the higher order rational and super‐regular breathers, and can be applied to general multibreather solutions, breathers on a nontrivial background (e.g., cnoidal waves), and other integrable systems. The constructed multisoliton solutions can also be generalized to capture the spontaneous emergence of rogue waves through the spontaneous synchronization of soliton norming constants, though finding these synchronization conditions represents a challenging problem for future studies.
When a key innovation becomes redundant: Patterns, drivers and consequences of elytral reduction inColeoptera
Authors: Goczał Jakub , Beutel Rolf G. , Gimmel Matthew L. , Kundrata Robin 
Published: December 2023

AbstractThe transformation of the fore wings into strongly sclerotized protective covers (elytra) is considered a fundamental evolutionary innovation of the megadiverse order Coleoptera. Surprisingly, these multifunctional structures have been reduced in many distantly related groups of beetles. Patterns, drivers and the evolutionary implications of this modification have never been comprehensively discussed. In the present study, we surveyed the entire order Coleoptera to analyse the patterns of elytral shortening and loss, with a special focus on prevalence, forms, degree of reduction and the functional background of this significant deviation from the coleopteran ground plan. Our analysis revealed that about 20% of all extant species (roughly 88,000 out of 442,275 spp.), distributed across all four suborders, have shortened or even absent elytra. The elytral loss was more frequent within the polyphagan series Elateriformia and Staphyliniformia. Moreover, we found that elytral reduction has independently occurred multiple times in the evolutionary history of Coleoptera and that it has been driven by a wide array of selective drivers. One of the main drivers is the improved flexibility of the uncovered abdomen and the correlated increased manoeuvrability in narrow spaces, as well as the option of using the flexible abdomen as a steering organ or to facilitate mating. Another common driver is mimicry, where exposed metathoracic wings potentially improve the overall similarity to hymenopteran models. Exposure of the abdomen can facilitate the targeted release of defensive abdominal gland secretions and was most likely a crucial step towards establishing relations with social insects enhanced by chemical communication. In the Elateriformia, and rarely in other lineages, elytral loss is a consequence of paedomorphosis, related to a specific resource‐allocation strategy. In many groups of beetles with reduced elytra, alternative defensive strategies can be found. This includes, for instance, aposematic coloration, chemical defence, mimicry or bioluminescence. Direct drivers of elytral loss in many groups remain unclear, and more studies are needed to understand the evolutionary background and implications of this significant morphological modification in Coleoptera.
A highly sensitive biotin‐based probe for small RNA northern blot and its application in dissecting miRNA function in pepper
Authors: Wang Hongzheng , Yu Ruimin , Zhu Qiangqiang , Tian Zhendong , Li Feng 
Published: December 2023

SUMMARYSmall RNAs play important roles in regulation of plant development and response to various stresses. Northern blot is an important technique in small RNA research. Isotope‐ and biotin‐ (or digoxigenin) labeled probes are frequently used in small RNA northern blot. However, isotope‐based probe is limited by strict environmental regulation and availability in many places in the world while biotin‐based probe is usually suffered from low sensitivity. In this study, we developed a T4 DNA polymerase‐based method for incorporation of a cluster of 33 biotin‐labeled C in small RNA probe (T4BC33 probe). T4BC33 probe reaches similar sensitivity as 32P‐labeled probe in dot blot and small RNA northern blot experiments. Addition of locked nucleic acids in T4BC33 probe further enhanced its sensitivity in detecting low‐abundance miRNAs. With newly developed northern blot method, expression of miR6027 and miR6149 family members was validated. Northern blot analysis also confirmed the successful application of virus‐based miRNA silencing in pepper, knocking down accumulation of Can‐miR6027a and Can‐miR6149L. Importantly, further analysis showed that knocking‐down Can‐miR6027a led to upregulation of a nucleotide binding‐leucine rich repeat domain protein coding gene (CaRLb1) and increased immunity against Phytophthora capsici in pepper leaves. Our study provided a highly sensitive and convenient method for sRNA research and identified new targets for genetic improvement of pepper immunity against P. capsici.
The effect of inequality of opportunity on entrepreneurship: Evidence from China
Authors: Zhou Guangsu , Liu Lizhong 
Published: December 2023

AbstractDespite the rich literature on income inequality, its impact on entrepreneurship is inconclusive, especially regarding the effect of different structures of inequality. In this research, we endeavour to explain such a phenomenon by formalising the inequality of opportunity. Utilising micro‐level data from China, we argue that it is inequality of opportunity that is negatively correlated with people's engagement in entrepreneurship, and this conclusion is consistent under a series of robustness checks. Our heterogeneity analysis indicates that the association between inequality of opportunity and entrepreneurship is stronger for self‐employment than for bigger‐scale private companies. It is also the strongest in regions with the lowest GDP per capita, the lowest fiscal expenditures and the smallest tertiary sector. These results suggest that economic development quality, economic structure and public service are important factors that influence the correlations between inequality of opportunity (IO) and entrepreneurial activities. Finally, we seek to understand the channels through which IO may be linked to entrepreneurship. Our results find that IO may discourage engagement in entrepreneurship by depressing human capital accumulation, access to credit, social capital and risk taking.
Evaluation of thoracic duct ligation and unilateral subphrenic pericardiectomy via a left fourth intercostal approach in normal canine cadavers
Authors: Price Anya K. , Mathews Kyle G. , Lawver Jody E. , Scharf Valery F. 
Published: December 2023

AbstractObjectiveTo investigate a left‐sided fourth intercostal approach to thoracic duct (TD) ligation and unilateral subphrenic pericardiectomy in dogs.Study designRetrospective computed tomography (CT) review and cadaveric study.AnimalsThirteen dogs with idiopathic chylothorax and 10 canine cadavers.MethodsA retrospective study of CT lymphangiograms in client‐owned dogs with idiopathic chylothorax evaluated location and branching of the TD at the left fourth intercostal space. A cadaveric study evaluated the efficacy of TD ligation at this site. Following methylene blue mesenteric lymph node injection, TDs were identified through a left fourth intercostal thoracotomy, ligated, and sealed. Unilateral subphrenic pericardiectomy was performed through the same incision. Computed tomography scans were performed to determine the success of TD ligation.ResultsA review of lymphangiograms revealed a single TD in 10/13 clinical cases at the fourth intercostal space. Three cases had additional branches. Thoracic duct ligation via a left fourth intercostal thoracotomy was successful in nine out of 10 cadavers. A single branch was noted intraoperatively in six out of 10, and two branches were noted in four out of 10 cadavers. All branches were observed on the left side of the esophagus.ConclusionTD ligation at the left fourth intercostal space was successfully performed in 9/10 canine cadavers and appeared feasible in a retrospective review of 10/13 clinical cases. Unilateral subphrenic pericardiectomy can also be performed via this approach.Clinical significanceFewer thoracic duct branches at this location in comparison with the standard caudal location may simplify TD ligation. If elected, unilateral subphrenic pericardiectomy can be performed through the same incision. Further investigation in clinical patients is warranted.
Hawking radiation under generalized uncertainty principle
Authors: Chau Tin-Long , Ho Pei-Ming , Kawai Hikaru , Shao Wei-Hsiang , Wang Cheng-Tsung 
Published: December 2023

AbstractThe generalized uncertainty relation is expected to be an essential element in a theory of quantum gravity. In this work, we examine its effect on the Hawking radiation of a Schwarzschild black hole formed from collapse by incorporating a minimal uncertainty length scale into the radial coordinate of the background. This is implemented in both the ingoing Vaidya coordinates and a family of freely falling coordinates. We find that, regardless of the choice of the coordinate system, Hawking radiation is turned off at around the scrambling time. Interestingly, this phenomenon occurs while the Hawking temperature remains largely unmodified.
The Effect of Teaching Physical Programming on Computational Thinking Skills and Self-Efficacy Perceptions Towards Computational Thinking
Authors: Yurdakök Ezgi Arzu , Kalelioğlu Filiz 
Published: December 2023

The study examined the effect of teaching text-based programming with a physical programming tool on secondary school students’ computational thinking skills and self-efficacy perceptions. The study was conducted according to a sequential explanatory design as a mixed method research. The study group consisted of 85 secondary school students. Within the scope of the study, a physical programming tool called Micro:bit was used to teach Python programming for a period of 6 weeks. Data were collected using the Self-Efficacy Perception Scale for Computational Thinking Skill, Bebras: International Challenge on Informatics and Computational Thinking Tasks, tests focused on programming tool, concepts, and processes, and through semi-structured interview questioning. According to the findings obtained from pretests and posttests, a significant and positive difference was found in the students’ computational thinking skills and self-efficacy perceptions towards computational thinking skill. As a result of having received instruction in programming, the students satisfactorily learnt the required programming concepts and processes. Through learning Python programming with a physical programming tool, the students not only gained the skills required to write appropriate syntax, and to test and debug code, but they also learnt programming concepts such as variables, conditional expressions, loops, and functions.
Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report
Authors: Prelog Polona Rus , Palandacic Anja Kokalj 
Published: December 2023

Abstract
Background
Cariprazine is a third-generation antipsychotic with a unique mechanism of action. It functions as a partial agonist with high affinity for dopamine D2 and D3 and serotonin 5-HT1A receptors, an antagonist for 5-HT2A (moderate affinity) and 5-HT2B (high affinity) receptors. It binds to histamine H1 receptors and has a low affinity for 5-HT2C and alpha 1A-adrenergic receptors and no affinity for muscarinic (cholinergic) receptors. Among the troubling side effects, symptoms related to impulse control, such as hypersexuality, pathological gambling, compulsive shopping, compulsive eating etc., have been reported with the use of antipsychotic medications. However, no reports have been published regarding impulse control symptoms associated with cariprazine. We report a case of cariprazine-induced hypersexuality in a patient with schizophrenia, which was resolved by discontinuation of the medication.

Case presentation
A 67-year-old Caucasian woman with schizophrenia was admitted to the hospital inpatient unit after she discontinued olanzapine and psychotic symptoms reappeared. Prior to that, she was in remission, taking olanzapine for approximately one year. After discontinuation, she experienced auditory hallucinations with persecutory delusions and became anergic and withdrawn, with blunted affect. Olanzapine was reintroduced, as it was proven successful in her past treatments. However, since there were no changes, especially in negative symptoms, cariprazine was added. Seven days after the introduction of cariprazine, the patient developed compulsive sexual behaviour. Therefore, cariprazine was discontinued, and the hypersexual behaviour was resolved.

Conclusions
In this case report, we describe hypersexual behaviour that could potentially be induced by cariprazine. As a single case study, conclusions cannot be drawn. Controlled studies are warranted to better determine causality and the significance of this possible side-effect of cariprazine.
Experiences of UK and Irish family carers of people with profound and multiple intellectual disabilities during the COVID-19 pandemic
Authors: Linden Mark , Leonard R , Forbes T , Brown M , Marsh L , Todd S , Hughes N , Truesdale M 
Published: December 2023

Abstract
Background
People with profound and multiple intellectual disabilities (PMID) have high and intensive support needs that ordinarily place significant strain on family carers. This was further heightened by the removal of many external supports during the COVID-19 pandemic. We sought to explore the experiences of family carers of people with PMID during the COVID-19 pandemic and understand what the longer-term impact might be on their lives.

Methods
Focus group interviews (n = 32) were conducted with family carers (n = 126) from the four countries of the UK and the Republic of Ireland. Participants were asked questions relating to their experiences of the COVID-19 pandemic, coping strategies, and challenges faced. All focus groups were conducted using the online platform, Zoom. These were audio recorded, transcribed verbatim and analysed employing inductive thematic analysis.

Findings
Three main themes were generated from the data including (1.0) COVID-19 as a double-edged sword (2.0), The struggle for support (3.0), Constant nature of caring. These included 11 subthemes. (1.1) ‘COVID-19 as a catalyst for change’, (1.2) ‘Challenges during COVID-19: dealing with change’, (1.3) ‘Challenges during COVID-19: fear of COVID-19’, (1.4); ‘The online environment: the new normal’ (2.1) ‘Invisibility of male carers’, (2.2) ‘Carers supporting carers’, (2.3) ‘The only service you get is lip service: non-existent services’, (2.4); ‘Knowing your rights’ (3.1) ‘Emotional response to the caring role: Feeling devalued’, (3.2) ‘Emotional response to the caring role: Desperation of caring’, (3.3) ‘Multiple demands of the caring role.’

Conclusions
The COVID-19 pandemic presented immense challenges to family carers of people with PMID but also provided some opportunities. Families had already struggled to receive many of the supports and services to which they were entitled to only to have these removed at the onset of the pandemic. The experiences of male carers have been largely absent from the literature with this research showing they want to be included in decision making and require tailored support services. Service providers should see the end of the COVID-19 pandemic as providing opportunity to re-examine current provision and design services with family carers. As the direct threat from COVID-19 diminishes and the experiences of those who lived through this period come to the fore, there is a need to re-examine current models and provision of support to family carers to better meet their needs.
Research gaps identified in Iran’s health technology assessment reports
Authors: Mohtasham Farideh , Yazdizadeh Bahareh , Mobinizadeh Mohammadreza 
Published: December 2023

Abstract
Introduction
Identifying gaps in the evidence is a useful byproduct of conducting a health technology assessment (HTA). This study aims to identify research gaps in Iran’s HTA reports.

Method
We reviewed the HTA reports published between 2014 and 2016. Then, we developed two separate questionnaires for principal investigators (PIs) and independent HTA researchers. The questionnaire for independent HTA researchers consisted of four main parts. However, the PIs’ questionnaire consisted of two main parts. We also conducted a literature search in the PubMed database in November 2017 to find frameworks for prioritizing research gaps. We also conducted a semi-structured interview with the head of the Iran’s HTA Office at that time and sought feedback based on his expert opinion about questionnaires, the priority-setting tool and our process for extracting research gaps.

Results
A total of 11 HTA reports published between 2014 and 2016 by Iran’s HTA Office were selected for the study. Of these 11 reports, 5 involved technologies related to medical equipment, while 6 involved medical and surgical interventions. Assessing the outcomes of technology use in various indications and updating HTAs when new evidence arises; evaluating the viewpoints of patients, clinicians and key technology users; conducting post-marketing evaluations of technology; comparing the impact of the technology in question to other treatments for the same condition; and requesting long-term clinical and cost–effectiveness data for technologies with limited follow-up periods were identified as the main gaps by independent HTA researchers and PIs.

Conclusions
The research gaps identified from Iran’s HTAs could be utilized by research funding agencies.
Evaluation of self-sampling-based cervical cancer screening strategy using HPV Selfy CE-IVD test coupled with home-collection kit: a clinical study in Italy
Authors: Feltri Giulia , Valenti Giulio , Isidoro Erica , Kaur Jaspreett , Treleani Marianna , Bartelloni Aurora , Mauro Claudia , Spiga Federica , Ticich Giulia , Di Napoli Michela , Biagi Claudia , Pachetti Maria , Centonze Sandro , Castriciano Santina , Zanchiello Sara , Giudici Fabiola , Gerin Daniela , Zanconati Fabrizio 
Published: December 2023

Abstract
Background
Primary human papillomaviruses (HPV) cervical cancer screening can be strengthened by offering home-collection of biological specimen as a valuable option to increase screening coverage. As recommended by World Health Organization (WHO), screening programs should consider whether the inclusion of HPV self-sampling as a complementary option within their existing screening algorithms could address the gaps in current coverage. However, few HPV screening tests are validated for self-sampling according to international guidelines. This study aimed to test a self-sampling-based screening strategy, complementary to the main screening program based on clinician-collected cervical samples. The study took place in Trieste, Italy, and it aimed to evaluate the feasibility of self-testing at home under an opt-in system during COVID-19 pandemic in order to exploit self-sampling to reduce the screening delay generated by the lockdown.

Methods
500 women, who should have received the screening call in 2020, were asked, via phone call, to participate in the study. To whom agreed, a home-collection kit, including a vaginal dry swab for specimen collection, was sent. The recipients performed the sample self-collection and sent back the swab through traditional mail using a prepaid envelope. Once received by the hospital, the samples were analyzed with HPV Selfy (Ulisse BioMed, Italy), a CE-IVD HPV screening test specifically validated for self-collection. Results were further compared using cobas® 4800 HPV (Roche, Switzerland).

Results
80% women sent back their swab, showing one of the highest return rate obtained in comparable studies. 34 HPV-positive women were followed up and underwent the Pap test, that revealed 8 low squamous intraepithelial lesions (LSIL) cases, later triaged to colposcopy. HPV Selfy was confirmed to be an adequate test for self-sampling-based screening.

Conclusions
This study further confirmed the feasibility of self-test at home screening strategy based on self-sampling with an opt-in system as a support method to enhance cervical cancer screening coverage in Italy. Enrolled women showed a high appreciation for this approach. HPV Selfy test demonstrated to be a valuable assay for cervical cancer screening based on home self-collection.
Trial registration: ASUGI Trieste n. 16008/2018 and amendment 02-11/09/2020.
Rayleigh-Jeans prethermalization and wave condensation in a nonlinear disordered Floquet system
Authors: Haldar Prosenjit , Mu Sen , Georgeot Bertrand , Gong Jiangbin , Miniatura Christian , Lemarié Gabriel 
Published: December 2023

Abstract
Periodically driven quantum systems make it possible to reach stationary states with new emerging properties. However, this process is notoriously difficult in the presence of interactions because continuous energy exchanges generally boil the system to an infinite temperature featureless state. Here, we describe how to reach nontrivial states in a periodically kicked nonlinear disordered system. One ingredient is crucial: both disorder and kick strengths should be weak enough to induce sufficiently narrow and well-separated Floquet bands. In this case, inter-band heating processes are strongly suppressed and the system can reach an exponentially long-lived prethermal plateau described by the Rayleigh-Jeans distribution. Saliently, the system can even undergo a wave condensation process when its initial state has a sufficiently low total quasi-energy.
Delayed Giant Pseudoaneurysm With Left-to-Right Shunt Following Postinfarct Ventricular Septal Perforation Repair
Authors: Machii Yojiro , Taoka Makoto , Hayashi Yuki , Harada Atsushi , Kamata Keita , Tanaka Masashi 
Published: December 2023

Abstract
Left ventricular pseudoaneurysm with a left-to-right shunt is extremely rare, requiring surgery if symptomatic; however, surgery has a high risk. Here, the case of a 77-year-old man with heart failure symptoms is reported, in which he develops a giant left ventricular pseudoaneurysm 16 months after ventricular septal perforation repair as a result of acute myocardial infarction, with mild shunt blood flow from the pseudoaneurysm to the right ventricle. Intraoperative findings showed a free wall rupture along the area where the patch was secured during the initial surgery. The patient was discharged on postoperative day 13, and postoperative examination revealed no abnormalities.