bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEI Method
Authors: Mei Kenneth K. 
Published: April 2005

AbstractThe basic principles of the measured equation of invariance (MEI) are presented. To apply the method, one needs to have fundamental knowledge of the finite difference and the integral representation of Maxwell's equations. The details of the formulas needed for solving specific problems are all contained in the cited references, so they are not included in this article. The purpose of this article is to inform the readers of the assumptions and reasoning of the method, the misgivings expressed by other researchers, what type of problems have already been solved by the method, and the latest developments in this method.
Wideband Slot and Printed Antennas
Authors: Elsherbeni Atef Z. , Eldek Abdelnasser A. , Smith Charles E. 
Published: April 2005

AbstractWideband antennas are in great demand for many of today's and future applications. This chapter presents new types of printed and slot antennas that support wideband applications centered at 10 GHz. The slot antennas are fed by coplanar waveguides and the printed antennas are fed by a microstrip lines. Sixteen elements of the printed antenna provides 71% bandwidth with scanning capabilities up to 50° without grating lobes. Sample designs of reconfigurable slot and microstrip patch antennas are also presented to provide mechanism for using narrow bandwidth antennas in wideband applications.
Bioequivalence evaluation of two brands of meloxicam tablets (promotion® and mobicox®): pharmacokinetics in a healthy female Mexican population
Authors: Marcelín‐Jiménez G. , Hernández José A. , Ángeles Alionka P. , Contreras L. , García A. , Hinojosa M. , Morales M. , Rivera L. , Martínez‐Rossier L. , Fernández A. 
Published: April 2005

AbstractWe conducted a randomized, crossover study in 23 healthy young female volunteers to compare the bioavailability of two brands of meloxicam (7.5 mg) tablets and to obtain pharmacokinetic parameters of this molecule in Mexican population not reported previously. Two tablets (15 mg) were administered as a single dose on 2 treatment days separated by a 1‐week washout period. After dosing, serial blood samples were collected for a period of 72 h. Plasma harvested was analyzed for meloxicam by a modified and validated high‐performance liquid chromatography (HPLC) method previously reported. Pharmacokinetic parameters AUC0–t, AUC0–α, Cmax, Tmax, ke, MRT and t1/2 were determined from plasma concentrations of both formulations, resulting in a Cmax 120% larger than and a Tmax 65% faster than those reported in other populations. AUC0–t, AUC0–α, and Cmax were statistically tested for bioequivalence after log transformation data in a non‐balanced design, and no significant differences were found either in 90% classical confidence interval (90% CI) or in Schuirmann test (p<0.05); thus, we concluded that bioequivalence existed between both formulations. Copyright © 2005 John Wiley & Sons, Ltd.
Craniofacial and axial skeletal defects induced by the fungicide triadimefon in the mouse
Authors: Menegola Elena , Broccia Maria Luisa , Di Renzo Francesca , Massa Valentina , Giavini Erminio 
Published: April 2005

AbstractBACKGROUND: Triadimefon is an antifungal derived from triazole. In in vitro whole‐rodent embryo cultures, triazole‐derivatives showed specific teratogenic effects at the branchial apparatus. The aim of the present work was to test in vivo triadimefon (FON), in order to verify a relationship between triazole exposure, embryonic abnormalities, and/or fetal malformations. METHODS: Pregnant CD‐1 mice were treated with 0–300 mg/kg FON by gavage on day 8 post coitum (p.c.) at 10:00 AM, and sacrificed on day 8 p.c. at 1:00 PM, on day 9 p.c. at 10:00 AM, on day 10 p.c. at 10:00 AM, and at term of gestation (day 18 p.c.). At midgestation, the embryos were processed for specific immunostainings to visualize the hindbrain segmentation (day 8 p.c.) and the neural crest cell migration (days 8 and 9 p.c.). Fetuses explanted at term were all processed for skeletal examination after double‐staining of osseous and cartilaginous tissues. RESULTS: At midgestation, the immunostaining of rhombomeres 3 and 5 showed a light scattering of the immunostained areas; the neural crest cell migration was unaffected, but their localization at the branchial arch level was abnormal. At term, several severe malformations were observed at the craniofacial and at the axial skeletal level. Ectopic cartilage was observed at the upper jaw. CONCLUSIONS: Triadimefon is teratogenic. The observed craniofacial malformations could be explained by an alteration of the rhombomeric organization and neural crest migration to the branchial arches; the axial abnormalities could be explained by the abnormal segmental identity specification. Birth Defects Res B 74:185–195, 2005. © 2005 Wiley‐Liss, Inc.
50‐Hz magnetic field (0.1‐mT) alters c‐fos mRNA expression of early post implantation mouse embryos and serum estradiol levels of gravid mice
Authors: Shi Yijun , Bao Xiuqi , Huo Xiaolin , Shen Zheng , Song Tao 
Published: April 2005

AbstractBACKGROUND: We exposed pregnant mice to magnetic or sham fields for 24 hr/day during Gestation Day (GD) 5.5–8.5 to study the effects of 50‐Hz 0.1‐mT sinusoidal magnetic fields on early pregnancy in mouse embryos and mice. METHODS: Mice were sacrificed on GD 8.5. Embryos and blood samples were collected. Reverse transcription polymerase chain reaction (RT‐PCR) was used to detect the expression of embryo c‐fos mRNA. The blood samples were tested through radioimmunoassay for serum estradiol levels and general examinations. RESULTS: We found that the expression of c‐fos mRNA of embryos under exposure was enhanced. We reported that 50‐Hz 0.1‐mT magnetic exposure induced the decline of serum estradiol levels of pregnancy mice on GD 8.5. General examinations of blood including white blood cell (WBC) count, red blood cell (RBC) count, and hemoglobin (HGB) did not show significant differences between the exposure group and the control group (sham exposure). CONCLUSIONS: Under the experimental conditions, 50‐Hz 0.1‐mT sinusoidal magnetic fields affected the development of early pregnancy mouse embryos and the dams to some extent. Birth Defects Res B 74:196–200, 2005. © 2005 Wiley‐Liss, Inc.
Tobacco smoke as inducer for gas phase‐controlled transgene expression in mammalian cells and mice
Authors: Weber Wilfried , Spielmann Manuela , Daoud El‐Baba Marie , Keller Bettina , Aubel Dominique , Fussenegger Martin 
Published: April 2005

AbstractCapitalizing on components evolved to metabolize ethanol in Aspergillus nidulans, we previously designed the first molecular gas–gene expression interface using gaseous acetaldehyde as the major inducer. This fungus‐derived acetaldehyde‐inducible gene regulation (AIR) system operated perfectly and enabled precise and reversible transgene expression dosing in a variety of mammalian cells. We now validate the use of mainstream cigarette smoke typically containing acetaldehyde at regulation‐effective nontoxic concentrations as a noninvasive modality to adjust transgene transcription in mammalian cells and mice. Indeed, tobacco smoke‐induced expression fine‐tuning of AIR‐driven transgenes was successful in mammalian cells. Even mice implanted with cells transgenic for AIR‐controlled SEAP (human secreted alkaline phosphatase) production showed serum SEAP levels correlating with inhaled tobacco smoke doses. Tobacco smoke‐controlled gene expression may foster clinical opportunities as well as advances in understanding smoke‐related pathologies. © 2005 Wiley Periodicals, Inc.
Two Novel Transition‐Metal Phosphite Compounds with 4‐, 6‐ and 12‐Membered Rings: Hydrothermal Syntheses, Crystal Structures and Magnetic Properties of Na2[M(HPO3)2] (M: Fe, Co).
Authors: Liu Wei , Chen Hao‐Hong , Yang Xin‐Xin , Zhao Jing‐Tai 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
LnCl(CN2) with Ln: La, Ce, and Pr: Synthesis and Structure of a New Lanthanide Chloride Cyanamide Related to the PbFCl‐Type Structure.
Authors: Srinivasan Radhakrishnan , Glaser Jochen , Tragl Sonja , Meyer H.‐Juergen 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation and Properties of the Full Series of Cuboidal Clusters [MoxW4‐xSe4(H2O)12] n+ (n = 4—6) and Their Derivatives.
Authors: Sokolov M. , Esparza P. , Hernandez‐Molina R. , Platas J. G. , Mederos A. , Gavin J. A. , Llusar R. , Vicent C. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Amberlyst‐15®‐Promoted Efficient 2‐Halogenation of 1,3‐Keto‐Esters and Cyclic Ketones Using N‐Halosuccinimides.
Authors: Meshram H. M. , Reddy P. N. , Sadashiv K. , Yadav J. S. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Amination of Ethers Using Chloramine‐T Hydrate and a Copper(I) Catalyst.
Authors: Albone David P. , Challenger Stephen , Derrick Andrew M. , Fillery Shaun M. , Irwin Jacob L. , Parsons Christopher M. , Takada Hiroya , Taylor Paul C. , Wilson D. James. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
NaNO2‐Mediated Transformation of Aliphatic Secondary Nitroalkanes into Ketones or Oximes under Neutral, Aqueous Conditions: How the Nitro Derivative Catalyzes Its Own Transformation.
Authors: Gissot Arnaud , N'Gouela Silvere , Matt Christophe , Wagner Alain , Mioskowski Charles 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Structure, and Characteristics of 1,2‐Dichlorovinyl Alkyl Ketones.
Authors: Bozhenkov G. V. , Leckovskaya G. G. , Larina L. I. , Ushakov P. E. , Dolgushin G. V. , Mirskova A. N. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Synthesis of Functionalized 4‐Hydroxycyclopent‐2‐en‐1‐ones by Cyclization of 1,3‐Bis(silyl) Enol Ethers and 1,3‐Dicarbonyl Dianions with 1,2‐Diketones.
Authors: Holtz Edith , Koehler Valentin , Appel Bettina , Langer Peter 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Entry to Functionalized Cycloalkylamines: Diastereoselective Intramolecular Amidoalkylation of N,O‐Acetal TMS Ether Possessing Allylsilane.
Authors: Jung Jong‐Wha , Shin Dong‐Yun , Seo Seung‐Yong , Kim Seok‐Ho , Paek Seung‐Mann , Jung Jae‐Kyung , Suh Young‐Ger 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design, Synthesis and Pharmacological Evaluation of Some Novel 2‐(4‐Nitrophenyl)‐3‐methylthio‐3‐(substituted)arylamino Acrylamides as Potential Antiinflammatory Agents.
Authors: Chhabria M. T. , Patel C. K. , Jani M. H. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reductive Debromination of 1,2‐Bis(bromomethyl)arenes Using Tetrakis(dimethylamino)ethylene (TDAE).
Authors: Nishiyama Yutaka , Kawabata Hiroshi , Kobayashi Akihiro , Nishino Toshiki , Sonoda Noboru 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selective [2 + 2 + 2] Cycloaddition of Nickel‐Benzyne and an Asymmetric 1,3‐Diyne: An Iterative Route to Substituted [n]Acenes.
Authors: Deaton Kimberly R. , Strouse Christopher S. , Gin Mary S. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Example of the C‐Alkylation of Indoles with Baylis—Hillman Acetates.
Authors: Yadav J. S. , Reddy B. V. Subba , Basak A. K. , Narsaiah A. V. , Prabhakar A. , Jagadeesh B. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
N—H Insertion Reactions of Primary Ureas: The Synthesis of Highly Substituted Imidazolones and Imidazoles from Diazocarbonyls.
Authors: Lee Sang‐Hyeup , Yoshida Kazuhiro , Matsushita Hana , Clapham Bruce , Koch Guido , Zimmermann Juerg , Janda Kim D. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Photochromic 4,5‐Dithienyl‐1,3‐oxathiol‐2‐ones.
Authors: Ivanov S. N. , Krayushkin M. M. , Lichitskii B. V. , Vorontsova L. G. , Starikova Z. A. , Dudinov A. A. , Martynkin A. Yu. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Functionalized Benzopyrans by Sequential [3 + 3]‐Cyclization—Williamson Reactions of 1,3‐Bis(trimethylsilyloxy)‐7‐chlorohepta‐1,3‐dienes.
Authors: Nguyen Van Thi Hong , Langer Peter 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of New Non‐Symmetrical Substituted 7,7′‐Bisindolizines by the Direct Reaction of 4,4′‐Bipyridinium‐ylides with Dimethyl Acetylenedicarboxylate.
Authors: Rotaru Alexandru V. , Danac Ramona P. , Druta Ioan D. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Substituted and Fused Spiro[benzo‐2‐azepine‐3,1′‐cyclohexanes].
Authors: Varlamov A. V. , Grudinin D. G. , Chernyshev A. I. , Levov A. N. , Lobanov I. Yu. , Borisov R. S. , Zubkov F. I. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New and Efficient Synthesis of 6,11‐Dihydro‐11‐ethyl‐5H‐dibenz[b,e]azepine Derivatives Starting from N‐Benzylanilines via Amino‐Claisen and Friedel—Crafts Methodologies.
Authors: Palma Alirio , Barajas Jacqueline Jaimes , Kouznetsov Vladimir V. , Stashenko Elena , Bahsas Ali , Amaro‐Luis Juan 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐Phenyl‐5,6,7,8‐tetrahydro‐1,6‐naphthyridines and 5‐Phenyl‐6,7,8,9‐tetrahydro‐5H‐pyrido[3,2‐c]azepines as Potential D1 Receptor Ligands.
Authors: Hussenether Thomas , Troschuetz Reinhard 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of Benzo[e]1,4‐oxathiepin‐5‐ones under Solvent‐Free Condition via Self‐Promoted Thiolysis of 1,2‐Epoxides.
Authors: Fringuelli Francesco , Pizzo Ferdinando , Tortoioli Simone , Vaccaro Luigi 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Three‐Component Joining Reaction of Primary Amines, Electron‐Deficient Olefins, and α‐Halogen‐Substituted Allylsilanes Catalyzed by Copper(I) Chloride.
Authors: Kozuka Makoto , Inoue Akihiko , Tsuchida Teruko , Mitani Michiharu 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
2‐Diethoxyphosphoryl‐4‐nitroalkanoates — Versatile Intermediates in the Synthesis of α‐Alkylidene‐γ‐lactones and Lactams.
Authors: Blaszczyk Edyta , Krawczyk Henryk , Janecki Tomasz 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimicrobial Activity of N‐(Substituted)‐N′‐ [1,2,4,8,10,11‐hexachloro‐6‐oxido‐12H‐dibenzo(d,g) (1,3,2)dioxaphosphocin‐6‐yl]ureas.
Authors: Haranath P. , Anasuyamma U. , Reddy P. Vasu Govardhana , Reddy C. Suresh 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3‐Acyl‐1‐alkyl‐2‐alkylseleno‐1‐cyclobutene Using Alkyneselenolate.
Authors: Koketsu Mamoru , Mizutani Kayo , Ogawa Tomoko , Takahashi Ayako , Ishihara Hideharu 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleosides Analogues.
Authors: Chatgilialoglu Chryssostomos , Ferreri Carla , Gimisis Thanasis , Roberti Marinella , Balzarini Jan , De Clercq Erik 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Phosphoramidate Protides of Carbocyclic 2′,3′‐Dideoxy‐2′,3′‐didehydro‐7‐deazaadenosine with Potent Activity Against HIV and HBV
Authors: Gudmundsson Kristjan S. , Wang Zhicheng , Daluge Susan M. , Johnson Lance C. , Hazen Richard , Condreay Lynn D. , McGuigan Christopher 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Biocoumarins from the Leaves of Murraya exotica
Authors: Teshima Naoko , Tsugawa Mayumi , Tateishi Akiko , Tokumaru Mariko , Matsubara Rie , Kimachi Tetsutaro , Ju‐ichi Motoharu , Ito Chihiro , Furukawa Hiroshi 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Activity of Rhodium‐Siloxide Complexes in Hydrosilylation of Allyl Ethers and Allyl Esters
Authors: Marciniec Bogdan , Walczuk Edyta , Blazejewska‐Chadyniak Paulina , Chadyniak Dariusz , Kujawa‐Welten Malgorzata , Krompiec Stanislaw 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats
Authors: Xu Lin , Liu Shao‐Lin , Zhang Jun‐Tian 
Published: April 2005

AbstractThe effect of clausenamide on synaptic transmission in the dentate gyrus of rats in vivo and its possible mechanism of action were investigated in this study. Four of 16 enantiomers showed potentiating effects on basal synaptic transmission in anesthetized animals. By comparing one pair of enantiomers, (−)‐clausenamide and (+)‐clausenamide, we can report three primary findings: (1) (−)‐clausenamide potentiated synaptic transmission in both anesthetized and freely moving animals while (+)‐clausenamide showed no or little effect; (2) (−)‐clausenamide increased the magnitude of long‐term potentiation (LTP) induced by high‐frequency stimulation (HFS) in anesthetized animals whereas (+)‐clausenamide had no effect; (3) voltage‐dependent calcium channels (VDCCs) calcineurin and calpain are involved in (−)‐clausenamide‐induced potentiation of synaptic transmission. Because hippocampal LTP is thought to reflect a cellular mechanism involved in learning and memory, our findings may provide the pharmacological basis for understanding the nootropic mechanisms of (−)‐clausenamide, which is the first chiral nootropic agent developed in China. Chirality 17:239–244, 2005. © 2005 Wiley‐Liss, Inc.
Anisotropic meshes and streamline‐diffusion stabilization for convection–diffusion problems
Authors: Linß Torsten 
Published: April 2005

AbstractWe study a convection‐diffusion problem with dominant convection. Anisotropic streamline aligned meshes with high aspect ratios are recommended to resolve characteristic interior and boundary layers and to achieve high accuracy. We address the question of how the stabilization parameter in the streamline‐diffusion FEM (SDFEM) and the Galerkin least‐squares FEM (GLSFEM) should be chosen inside the layers. Using a residual free bubbles approach, we show that within the layers the stabilization must be drastically reduced. Copyright © 2005 John Wiley & Sons, Ltd.
An approach to understanding avalanche statistics in mean‐field driven threshold systems
Authors: Preston Eric F. , Sá Martins Jorge S. 
Published: April 2005

AbstractDriven threshold models that produce complex histories of avalanches are used to simulate the dynamics of many complex interacting systems, such as earthquake generating faults and neural networks. A mean‐field model may be formulated in a way that makes avalanches Abelian, so the final size of the avalanche depends only on the initial conditions, not the algorithm. If the initial stress distribution is statistically stationary, the avalanche size distribution is generated by the first intersection of a random process with a curvilinear boundary. Solutions show that such mean‐field models are never truly critical, but always exhibit dissipation or finite‐size effects. © 2005 Wiley Periodicals, Inc. Complexity 10:68–72, 2005
Quantum calculation of thermal effect in quantum‐dot cellular automata
Authors: Sturzu Ioan , Khatun Mahfuza 
Published: April 2005

AbstractWe present a theoretical study of thermal effect in quantum‐dot cellular automata (QCA). An extended Hubbard‐type model for the Hamiltonian of the QCA arrays, and canonical distribution were used to obtain thermal average of polarization for the QCA cells. A full‐basis quantum method has been used for the calculation of response function for a two‐ and a three‐cell array system. Each cell is composed of four dots located at the corners of the cells. Results show that the nonlinear behavior of the response function functions decay with the temperature as well as with the number of cells in the array. © 2005 Wiley Periodicals, Inc. Complexity 10: 73–78, 2005
Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two‐choice drug discrimination task
Authors: Prus Adam J. , Philibin Scott D. , Pehrson Alan L. , Stephens Chad L. , Cooper Rhiannon N. , Wise Laura E. , Porter Joseph H. 
Published: April 2005

AbstractClozapine (CLZ) drug discrimination is used as a preclinical model to evaluate compounds for putative atypical antipsychotic properties. In rats, a 1.25 mg/kg CLZ training dose appears to have greater pharmacological specificity for atypical antipsychotic drugs than the traditional 5.0 mg/kg CLZ training dose; however, methodological differences among studies have precluded a direct comparison between these training doses. In the present study, rats were trained to discriminate a 5.0 mg/kg CLZ dose from vehicle in a two‐choice drug discrimination task using methods similar to those in a previous study from our laboratory that used a 1.25 mg/kg CLZ training dose. Clozapine produced full substitution (≥80% CLZ‐lever responding) for itself at the training dose (5.0 mg/kg). The atypical antipsychotics olanzapine, quetiapine, and ziprasidone also produced full substitution for 5.0 mg/kg CLZ, whereas the atypical antipsychotics risperidone and sertindole produced partial substitution (≥60% CLZ‐lever responding). The typical antipsychotic, thioridazine, produced full substitution for the 5.0 mg/kg CLZ training dose, but the typical antipsychotics chlorpromazine, fluphenazine, and haloperidol failed to substitute for clozapine. In a subgroup of 1.25 mg/kg CLZ‐trained rats, ziprasidone produced strong partial substitution (73.0 % CLZ‐lever responding) for the 1.25 mg/kg CLZ training dose. Based on these findings, some atypical antipsychotic drugs (i.e., quetiapine and ziprasidone) produce full substitution only for the 5.0 mg/kg CLZ training dose, whereas other atypical antipsychotic drugs (i.e., sertindole and risperidone) produce full substitution only for the 1.25 mg/kg CLZ training dose. Thus, both of these training doses are important for the screening of putative atypical antipsychotic drugs with the clozapine drug discrimination assay. Drug Dev. Res. 64:55–65, 2005. © 2005 Wiley‐Liss, Inc.
Antinociceptive and antiinflammatory effects of ketoprofen are potentiated by a vitamin B mixture in the rat
Authors: Rodríguez‐Silverio Juan , Aguilar‐Carrasco José Carlos , Reyes‐García Gerardo , Medina‐Santillán Roberto , Flores‐Murrieta Francisco J. 
Published: April 2005

AbstractKetoprofen is a nonsteroidal antiinflammatory drug (NSAID) widely used in therapeutics. However, gastrointestinal toxicity may limit its use. To reduce the requirements of NSAIDs and hence their toxicity, these compounds have been combined with several drugs. B vitamins increase the analgesic activity of NSAIDs, but conflicting results have been obtained. The purpose of this study was to establish whether a vitamin B mixture can increase the antinociceptive effect of ketoprofen in the thermal paw stimulation model and in antiinflammatory activity in carrageenan‐induced paw edema in the rat. Ketoprofen produced a dose‐dependent antinociception, whereas a mixture of B vitamins produced a very limited antinociceptive effect. However, B vitamins were able to increase the antinociceptive effect of ketoprofen, reaching effects similar to those obtained with the maximal dose of ketoprofen tested. Ketoprofen produced a dose‐dependent antiinflammatory activity and B vitamins also produced significant antiinflammatory effects. When ketoprofen was combined with a mixture of B vitamins, an increase in the antiinflammatory action was observed. These results indicate that coadministration of B vitamins with ketoprofen can increase both antihyperalgesic and antiinflammatory effects. Thus, B vitamins are effective as analgesic adjuvants in the models tested. Drug Dev. Res. 64:66–70, 2005. © 2005 Wiley‐Liss, Inc.