bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some Under Heaven
Authors: Saussy Haun 
Published: January 2025

Abstract
The extension of World Literature, a profoundly valuable concept, implies a degree of homogeneity among its objects which undermines the promise of this disciplinary field. Enlarging the scope of World Literature to include the vast corpus of Chinese writing only raises the stakes, for this corpus is internally heterogeneous, temporally differentiated, and does not always answer to the generic labels most commonly assumed in the constitution of comparables by investigators in World Literature. The present article pleads for a deeper temporal range and a greater categorical flexibility in the theory of World Literature, and above all for a suspension of the privilege tacitly granted to European neoclassical ideas of genre and style.
Influence of printing orientation on properties of 3D-printed parts produced by polymer jetting technology
Authors: Bellamkonda Prasanna Nagasai , Dwivedy Maheshwar 
Published: January 2025

This study investigates the impact of printing orientation on the mechanical properties and surface characteristics of parts produced using VeroWhitePlus RGD835 polymer material in a layer-based Polymer Jetting Technology process. Tensile, hardness, and surface roughness tests were conducted to evaluate the influence of different printing orientations on the properties of the printed samples. The results show that printing orientation significantly affects both the mechanical strength and surface roughness of the parts. Specifically, samples printed in the XZ, YZ, and vertical orientations exhibited 20–30% higher tensile strength and 15–25% greater hardness compared to those printed in XY and other orientations. Surface roughness values varied by up to 10 µm across orientations but did not directly correlate with tensile strength and hardness, suggesting a complex interaction between orientation, layer bonding, and material properties. This anisotropic behavior is attributed to the non-uniform absorption of light energy during the jetting process, which causes varying layer bonding and material density across different regions of the printed parts. Additionally, areas with higher energy absorption, such as the edges of layers, exhibited smoother surfaces and enhanced mechanical properties, while regions with lower energy absorption showed rougher surfaces and reduced strength. Fracture surface analysis revealed brittle fracture characteristics with localized pressures and voids between layers, weakening the material’s ability to withstand deformation. These findings provide valuable insights into the optimization of Polymer Jetting Technology processes, particularly in selecting printing orientations and adjusting process parameters such as light exposure intensity, to improve mechanical performance and surface quality.
Effects of a home-based pelvic floor muscle training with and without action and cue observation on urinary incontinence after prostatectomy: A randomized controlled trial
Authors: Russo Filippo , Temporiti Federico , Cifoletti Damiana , Benaglia Elisabetta , Franzini Claudia , Fasulo Vittorio , Paciotti Marco , Buffi Nicolò Maria , Gatti Roberto 
Published: January 2025

Objective To investigate the effects of a home-based pelvic floor muscle training with and without action and cue observation on urinary incontinence after prostatectomy. Design Two-armed single-blind randomized controlled trial. Setting Humanitas Research Hospital, Milan, Italy. Participants Ninety-two participants with age between 40 and 80 years and urinary incontinence after robot-assisted laparoscopic prostatectomy. Intervention Participants were randomized into an action and cue observation ( n = 46) or control ( n = 46) group undergoing an 8-week home-based pelvic floor muscle training. Action and cue observation group observed video clips showing exercises synchronized with a visual cue indicating the correct pelvic floor muscle activation timing and imitated the observed tasks. Control group observed landscape video clips and performed the same exercises of experimental group. Main measures A blinded physiotherapist assessed participants for urinary leakages (24-h pad test), symptom severity (International Prostate Symptoms Score and International Prostate Symptoms Score - Quality of Life), quality of life (International Consultation on Incontinence Questionnaire - Short Form), and erectile dysfunction (International Index of Erectile Function) before and after the training. Results All participants improved urinary leakages, symptom severity, and quality of life after training. Action and cue observation group revealed significantly larger improvements in 24-h pad test (mean difference: 106.1 g, 95% CI: 13.4 g, 199.1 g, p = .037) than control group. Conclusions Home-based pelvic floor muscle training with action and cue observation led to larger improvements in urinary continence compared to the same training without action and cue observation after prostatectomy.
Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study
Authors: Shahzil Muhammad , Chaudhary Ammad Javaid , Javaid Saad , Moond Vishali , Tepe Gokturk , Faisal Muhammad Saad , Khaqan Muhammad Ali , Kutait Anas 
Published: January 2025

Objectives Central nervous system complications of acute pancreatitis (AP) can result in cerebral edema (CE). We assessed the risk of serious outcomes and health care features associated with CE in patients hospitalized with AP. Methods We conducted a retrospective cohort study using the National Inpatient Sample database. Patients were divided into the AP-CE group that developed CE and the AP-only group that did not. Outcome data were analyzed using Stata software. Results Among 543,464 patients hospitalized with AP, 220 (0.04%) developed CE. In multivariate analysis, primary outcomes included increased length of hospital stay (adjusted odds ratio [aOR] 10.1; 95% confidence interval [CI] 0.50–19.70), hospital charges (aOR USD 208,713; 95% CI 27,095–390,330), and risk of death (aOR 17.17; 95% CI 5.88–50.07) in the AP-CE group. Secondary outcomes showed patients with AP-CE had a significantly increased risk of serious complications, particularly cardiac arrest (aOR 64.24; 95% CI 24.27–170.02), and higher hospital resource utilization. Conclusion Patients with AP who develop CE face worse outcomes, including increased mortality risk, prolonged hospital stay, and greater resource utilization. Timely identification and effective management of CE in AP may reduce mortality and ease the health care burden associated with this neurological complication.
Associations of Traumatic Brain Injury and Mild Behavioral Impairment With Cognitive Function and Dementia
Authors: Richey Lisa N. , Daneshvari Nicholas O. , Young Lisa , Bray Michael J. C. , Gottesman Rebecca F. , Mosley Thomas , Walker Keenan A. , Schneider Andrea L. C. , Peters Matthew E. 
Published: January 2025

Objective Traumatic Brain Injury (TBI) may contribute additional complexity to the clinical picture of mild behavioral impairment (MBI). MBI, a behavioral analog to mild cognitive impairment (MCI), is comprised of five neuropsychiatric domains: decreased motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, and abnormal perception/thought content. We investigated (1) if cross-sectional associations of cognitive status with MBI symptoms differ by TBI status and (2) if prospective associations of MBI domain positivity with incident dementia risk differ by TBI status. Methods 2246 participants without dementia from the Atherosclerosis Risk in Communities Study were included (mean age = 75.6 years, 59.0% female). TBI was defined by self-report/ICD-9/10 codes, MBI via an established algorithm based on the Neuropsychiatric Inventory Questionnaire, and baseline cognitive status/incident dementia using neuropsychological tests, informant interviews, and hospital/death certificate codes. Results Cross-sectionally, although MCI status was associated with greater odds of MBI, this did not differ based on TBI status (MCI with TBI: OR = 2.04, 95% CI = 1.44-2.88, MCI without TBI: OR = 1.60, 95% CI = 1.20-2.14). Individuals with MCI (with or without TBI) were more likely to have decreased motivation, affective dysregulation, and impulse dyscontrol. Prospectively, positivity in 1+ MBI domains was associated with increased risk of incident dementia, not differing by TBI status (no TBI and MBI: HR = 2.15, 95% CI = 1.55-2.99, TBI and MBI: HR = 2.62, 95% CI = 1.81-3.80). Conclusions Neither cross-sectional associations between cognitive status and MBI domain positivity nor prospective associations of MBI domain positivity with incident dementia risk differed by TBI status. How TBI may relate to neuropsychiatric symptomatology in the context of neurodegenerative processes requires further clarification.
Investigating the role of IL-6 in the pathogenesis of systemic lupus erythematosus: Insights from bone marrow mesenchymal stem cells
Authors: Zhang Zhiwen , Zhu Silang , Li Qian , Wei Shanshan , Yin Li , Zhu Junhao , Yang Shan , Zhang Wenjing , Lai Kuan 
Published: January 2025

Background Systemic lupus erythematosus is a common autoimmune disease. Studies have suggested that defective stem cells could be involved in the pathogenesis of systemic lupus erythematosus, which leads to changes in the function of immune cells. By observing the cell morphology, autophagy, and senescence of bone marrow mesenchymal stem cells (BMSCs) from lupus mice and normal controls, this study investigated the role of IL-6 in autophagy and senescence of BMSCs and explored relevant mechanisms. Method Female MRL/lpr and C57 mice with similar weights and sizes at 20–22 weeks old were selected. BMSCs were isolated using the whole bone marrow adherent method. Quantitative real-time polymerase chain reaction, β-galactosidase staining, western blotting, and ELISA were used to detect autophagy and senescence. Result Compared with BMSCs from normal mice, BMSCs from lupus mice exhibited low autophagy and premature senescence with a senescence-associated secretory phenotype. The addition of exogenous IL-6 increased the protein levels of p-STAT3 and Bcl-2, and in the IL-6-treated group, the premature senescence of cells increased and autophagy decreased. Conclusion The biological functions of BMSCs from MRL/lpr lupus mice were impaired. IL-6 prevents autophagy and subsequently promotes the senescence of BMSCs by activating the IL-6/STAT3 pathway.
Low rate of healing and high incidence of complications in benign pediatric bone tumors treated with synthetic calcium sulfate–calcium phosphate bone graft
Authors: Siddiqui Ali A , Andras Lindsay M , Myers Annika Y , Fan Bensen B , Bennett James , Illingworth Kenneth D , Skaggs David L , Tolo Vernon T 
Published: January 2025

Background: Synthetic calcium sulfate–calcium phosphate bioceramic composite has been developed as a material for bone grafting; however, the literature is limited on outcomes of benign bone tumors treated with bone grafting. This study aims to investigate the outcomes of benign pediatric bone tumors treated with a calcium sulfate–calcium phosphate composite bone graft. Methods: A retrospective review at a tertiary pediatric hospital with benign bone tumors treated with curettage and bone grafting with a calcium sulfate–calcium phosphate synthetic bone graft from 2008–2018 was included. Minimum follow-up was 6 months. Results: Twenty-seven patients met inclusion criteria with a mean age of 10.3 ± 4.5 years and follow-up was 37.2 ± 22.3 months. Diagnoses were unicameral bone cysts ( n = 16) and aneurysmal bone cysts ( n = 11). Pathologic fracture was present in 48% (13/27) of patients on admission. All patients were treated using synthetic bone grafts and 37% (10/27) with internal fixation. Following index treatment, 96% (26/27) had resolution of pain and returned to full activity at 13.4 ± 10.7 weeks. Complications occurred in 33% (9/27) of patients; one developed chronic hip pain resulting in decreased physical activity, seven had a tumor recurrence without fracture, and one had tumor recurrence with pathologic fracture. Revision surgery was required in 26% (7/27) of cases. Per the modified Neer outcomes rating system, 52% of patients had a healed bone lesion, 4% had a healing lesion with a bone defect, and 44% had a persistent/recurrent cyst. Conclusions: Children with benign bone tumors treated with curettage and bone grafting using a calcium sulfate–calcium phosphate composite had a high incidence of complications and revision surgery. Level of evidence: IV.
Interest, uptake, and feasibility trial of a real-life digital health intervention to improve lifestyle in Brazil
Authors: De Boni Raquel B , Mota Jurema C , Duncan Michael , Linconl Leonardo , Costa Giovanna Lucieri Alonso , Pimentel Sofia , Sales Kamila P , Gaspar Fabiana , Adaes Fernanda , Schuch Felipe B , Balanzá-Martinez Vicent , Kapczinski Flavio , Lima Renato S 
Published: January 2025

Objective Promoting healthy lifestyle behaviors is essential for preventing and managing chronic and mental health conditions. This study aims to present a digital health platform accessible via PC or smartphone, VIVA!, designed to foster lifestyle change among the Brazilian population. It evaluates interest, uptake, acceptability, usability, adherence, and retention over 12 weeks. Methods A fully online feasibility trial was conducted from April to December 2023. Participants were adults who lived in Rio de Janeiro and reported using the Brazilian Public Health System. Interest in VIVA! and uptake were assessed via recruitment metrics. Acceptability and usability were measured using the Mobile App Rating Scale (MARS). Adherence was calculated as the percentage of completed challenges over 12 weeks, and retention was tracked at 4, 8, and 12 weeks. Results Of 3812 individuals reached, 27.2% expressed interest in the app, with an uptake rate of 65.4%. A total of 401 participants were enrolled, predominantly women (73.3%) with higher education (61.6%). MARS acceptability scores were 2.9 for quality and 3.5 for specificity. Usability scores averaged around 3, with aesthetics rated the highest. Retention at 12 weeks was 4.5%, and the average adherence rate was 11.2%. Conclusion The VIVA! attracted women and highly-educated individuals, but its effectiveness was constrained by high attrition. These findings highlight key challenges in DHI implementation, including the need for robust outreach, iterative improvements, and strategies to sustain engagement. Addressing digital access, literacy inequities, and strengthening regulations are critical for the future success and equity of DHIs in public health systems. Trial registration The trial was registered at the Brazilian Clinical Trials Registry (Registro Brasileiro de Ensaios Clínicos -REBEC)—number RBR-2ssyb6q.
Comprehensive transcriptomic analysis reveals turnip mosaic virus infection and its aphid vector Myzus persicae cause large changes in gene regulatory networks and co-transcription of alternative spliced mRNAs in Arabidopsis thaliana
Authors: Herath Venura , Casteel Clare L. , Verchot Jeanmarie 
Published: January 2025

Abstract

Background
Virus infection and herbivory can alter the expression of stress-responsive genes in plants. This study employed high-throughput transcriptomic and alternative splicing analysis to understand the separate and combined impacts on host gene expression in Arabidopsis thaliana by Myzus persicae (green peach aphid), and turnip mosaic virus (TuMV).

Results
By investigating changes in transcript abundance, the data shows that aphids feeding on virus infected plants intensify the number of differentially expressed stress responsive genes compared to challenge by individual stressors. This study presents evidence that the combination of virus-vector-host interactions induces significant changes in hormone and secondary metabolite biosynthesis, as well as downstream factors involved in feedback loops within hormone signaling pathways. This study also shows that gene expressions are regulated through alternative pre-mRNA splicing and the use of alternative transcription start and termination sites.

Conclusions
These combined data suggest that complex genetic changes occur as plants adapt to the combined challenges posed by aphids and the viruses they vector. This study also provides more advanced analyses that could be used in the future to dissect the genetic mechanisms mediating tripartite interactions and inform future breeding programs.
Radioresistance in rectal cancer: can nanoparticles turn the tide?
Authors: Coelho Diogo , Estêvão Diogo , Oliveira Maria José , Sarmento Bruno 
Published: January 2025

Abstract
Rectal cancer accounts for over 35% of the worldwide colorectal cancer burden representing a distinctive subset of cancers from those arising in the colon. Colorectal cancers exhibit a continuum of traits that differ with their location in the large intestine. Due to anatomical and molecular differences, rectal cancer is treated differently from colon cancer, with neoadjuvant chemoradiotherapy playing a pivotal role in the control of the locally advanced disease. However, radioresistance remains a major obstacle often correlated with poor prognosis. Multifunctional nanomedicines offer a promising approach to improve radiotherapy response rates, as well as to increase the intratumoral concentration of chemotherapeutic agents, such as 5-Fluorouracil. Here, we revise the main molecular differences between rectal and colon tumors, exploring the complex orchestration beyond rectal cancer radioresistance and the most promising nanomedicines reported in the literature to improve neoadjuvant therapy response rates.

Graphical Abstract
Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study
Authors: Wang Dong-Dong , Jia Ming-Qian , Xu He-Li , Li Yu , Liu Jia-Xin , Liu Jia-Cheng , Sun Jia-Nan , Cao Fan , Wu Lang , Liu Fang-Hua , Li Yi-Zi , Wei Yi-Fan , Li Xiao-Ying , Xiao Qian , Gao Song , Huang Dong-Hui , Zhang Tao , Gong Ting-Ting , Wu Qi-Jun 
Published: January 2025

Abstract

Background
The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce.

Objective
This study aimed to investigate these associations in a prospective cohort of Chinese patients with OC.

Methods
In this prospective cohort study, patients with epithelial OC completed a food frequency questionnaire at diagnosis and 12 months post-diagnosis, and were followed from 2015 to 2023. Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Dose–response relationships were evaluated by restricted cubic splines.

Results
Among the total 560 patients with OC, there were 211 (37.68%) deaths during a median follow-up of 44.40 (interquartile range: 26.97–61.37) months. High pre-diagnosis TAC (HR = 0.58; 95% CI 0.38–0.8) and vitamin C intake (HRT3 vs. T1 = 0.36; 95% CI 0.21–0.61), and post-diagnosis TAC (HR = 0.57; 95% CI 0.37–0.8), CDAI (HR = 0.57; 95% CI 0.33–0.9), and β-carotene intake (HRT3 vs. T1 = 0.55; 95% CI 0.32–0.97) were significantly associated with improved OS. Compared to patients with constantly low pre- and post-diagnosis TAC and CDAI, those with consistently higher TAC (HRMedium-Medium vs. Low-Low = 0.53; 95% CI 0.29–0.97; HRHigh-High vs. Low-Low = 0.40; 95% CI 0.16–0.94) and CDAI (HRHigh-High vs. Low-Low = 0.33; 95% CI 0.12–0.88) experienced better OS.

Conclusion
High pre- and post-diagnosis TAC, and post-diagnosis CDAI were associated with improved OC survival, suggesting that consistent high-intake of antioxidant-rich food may be beneficial for the prognosis of OC.
KaRhab: an international online registry for cardiac rhabdomyomas
Authors: Herrmann Vera-Maria , Arelin Maria , Bergner Caroline G. , Herrmann Julia , Janz Paula , Kiep Henriette , Mueller Annika , Syrbe Steffen , Wagner Robert , Wannenmacher Bardo , Wolf Nadine , Weidenbach Michael , Strehlow Vincent 
Published: January 2025

Abstract

Background
Cardiac rhabdomyoma (RHM) is considered one of the most frequent benign heart tumors in children. However, encounters with cardiac RHM in clinical practice remain rare. Clinical information is primarily available in the form of single case reports or smaller studies with a shortage of large-scale reviews encompassing a substantial number of cases.

Results
In order to congregate existing and future information on cardiac RHM we established a web-based cardiac RHM online registry using an online survey tool. In addition we integrated previously published data from individual case reports and case series. The evaluation of this paper is intended to provide a brief overview of the cohort that we have been able to include so far. Our findings mainly confirm the previous knowledge on cardiac RHM. At the same time, our cohort shows a clear heterogeneity in the treatment methods with regard to rhabdomyomas requiring therapy and revealed a bias between literature data and our registry data with regard to symptoms and need for therapy.

Conclusion
In the view of the heterogeneity of treatment methods, a systematic overview of cardiac RHM is all the more important, especially as specific drug treatment options now exist. The registry should not just provide a comprehensive and informative overview of causes, time course, symptoms and therapeutic options of cardiac RHM but also facilitate information sharing among clinicians and researchers and serve as a basis for future clinical and pharmacological studies.
Development and experimental validation of a machine learning model for the prediction of new antimalarials
Authors: Kore Mukul , Acharya Dimple , Sharma Lakshya , Vembar Shruthi Sridhar , Sundriyal Sandeep 
Published: January 2025

Abstract
A large set of antimalarial molecules (N ~ 15k) was employed from ChEMBL to build a robust random forest (RF) model for the prediction of antiplasmodial activity. Rather than depending on high throughput screening (HTS) data, molecules tested at multiple doses against blood stages of Plasmodium falciparum were used for model development. The open-access and code-free KNIME platform was used to develop a workflow to train the model on 80% of data (N ~ 12k). The hyperparameter values were optimized to achieve the highest predictive accuracy with nine different molecular fingerprints (MFPs), among which Avalon MFPs (referred to as RF-1) provided the best results. RF-1 displayed 91.7% accuracy, 93.5% precision, 88.4% sensitivity and 97.3% area under the Receiver operating characteristic (AUROC) for the remaining 20% test set. The predictive performance of RF-1 was comparable to that of the malaria inhibitor prediction platform (MAIP), a recently reported consensus model based on a large proprietary dataset. However, hits obtained from RF-1 and MAIP from a commercial library did not overlap, suggesting that these two models are complementary. Finally, RF-1 was used to screen small molecules under clinical investigations for repurposing. Six molecules were purchased, out of which two human kinase inhibitors were identified to have single-digit micromolar antiplasmodial activity. One of the hits (compound 1) was a potent inhibitor of β-hematin, suggesting the involvement of parasite hemozoin (Hz) synthesis in the parasiticidal effect. The training and test sets are provided as supplementary information, allowing others to reproduce this work.