bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnóstico de melanoma y nuevas tecnologías
Authors: Acosta Ana Clara , Chiappe César 
Published: December 2023

Se sabe que todas las lesiones tumorales, incluidas las melanocíticas, comienzan con alteraciones genéticas variadas que aumentan en número y características desde la benignidad hasta la malignidad.
En los últimos años, y en base a esas alteraciones genéticas definidas, se han desarrollado otros métodos de diagnóstico. Estos nuevos test moleculares serían de utilidad en aquel limitado número de lesiones donde la histología y la inmunohistoquímica convencional no diferencian benignidad de malignidad, y por lo tanto podríamos estar tratando en más o en menos una lesión melanocítica.
Con esta combinación de un diagnóstico más certero y temprano, y los tratamientos dirigidos al blanco específico, podremos lograr un mejor pronóstico para los pacientes con melanoma. El objetivo es conseguir que estos nuevos estudios moleculares tengan una utilidad clínica.
Tratamiento de una cicatriz hipopigmentada con solución oftálmica de bimatoprost al 0,3% con microneedling y tacrolimus al 0,1%
Authors: Minaudo Carla 
Published: December 2023

Se comunica el caso de una paciente de 32 años, de piel negra, con una cicatriz hipopigmentada en el brazo, de 40 × 15 cm, posterior a una quemadura con agua hirviendo 5 meses antes del inicio del tratamiento.
En primer término, se indicó tacrolimus ungüento al 0,1% una vez por día durante un mes, con el resultado de una hiperpigmentación perifolicular. A partir de ese momento se realizaron 8 sesiones de microneedling y aplicación de solución oftálmica de bimatoprost al 0,3%.
El microneedling se aplicó con un dispositivo manual motorizado con una profundidad de 0,25 mm para obtener un petequiado puntiforme. Luego se aplicó la solución oftálmica hasta su absorción y se realizó un segundo ciclo de microneedling. Las primeras 6 sesiones fueron mensuales y las últimas 2, trimestrales.
Al mismo tiempo, la paciente mantuvo el tratamiento con tacrolimus hasta 4 meses después de finalizar el microneedling.
El resultado fue exitoso, con una repigmentación completa.
El bimatoprost, un análogo de las prostaglandinas, se utiliza como tratamiento oftalmológico para el glaucoma de ángulo abierto y en dermatología para la hipotricosis. Es conocido su efecto adverso de hiperpigmentación de la piel circundante y del iris. Este se relaciona con el aumento de la melanogénesis y la proliferación de melanocitos y sus dendritas debido al efecto proinflamatorio con liberación de prostaglandinas, situación similar a la inflamación con hiperpigmentación resultante de la exposición a la radiación UV. Aprovechando esta reacción adversa, se lo ha empleado como tratamiento fuera de prospecto (off label) en pacientes con vitiligo.
Por su parte, se aplicó el microneedling con la finalidad de aumentar la permeabilidad cutánea al fármaco a través de las pequeñas incisiones generadas por esa técnica. Asimismo, los autores comentan que se mantuvo el tacrolimus por su efecto antiinflamatorio para permitir la recuperación y regeneración de los melanocitos.
PERAN KOMUNIKASI KELUARGA DALAM PENDAMPINGAN BELAJAR DARING ANAK AUTIS
Authors: Nurrezqia Agnessya , Ramadhana Maulana Rezi 
Published: December 2023

Sejak adanya pandemi Covid-19 pada awal tahun 2020, maka seluruh kegiatan belajar dialihkan kerumah melalui sistem pembelajaran daring. Dalam situasi tersebut, peran komunikasi orang tua menjadi lebih penting dalam membantu proses belajar daring anak, namun akan menjadi lebih menantang ketika anak-anak yang mereka damping memiliki gangguan autis. Penelitian ini bertujuan untuk menggambarkan peran komunikasi orang tua dalam pendampingan belajar daring anak autis selama masa pandemi Covid-19. Penelitian ini menggunakan metode penelitian kualitatif, data hasil wawancara terhadap 6 (enam) ibu di Yayasan Biruku Indonesia Kota Bandung. Analisis data menggunakan analisis tematik dibantu dengan ATLAS.ti versi 8. Hasil penelitian menunjukan bahwa peran percakapan orang tua dalam pendampingan belajar daring selama masa pandemi Covid-19 muncul melalui pemberian pengulangan pesan, penyampaian komunikasi nonverbal dan pemberian apresiasi pada anak autis, serta peran konformitas muncul melalui pemberian partisipasi orang tua, penanaman sikap, pola asuh orang tua dan penanaman keseragaman. Adanya umpan balik berupa reaksi emosional anak selama pendampingan belajar daring menjadi temuan yang melengkapi konsep. Penerapan konformitas yang tinggi dalam pendampingan belajar anak membentuk reaksi afektif dan kognitif yang meningkat selama masa pembelajaran daring.
EVALUASI PROGRAM PELATIHAN GOOGLE CERTIFIED EDUCATOR DALAM PENINGKATAN PROFESIONALITAS GURU: STUDI KASUS SEKOLAH KRISTEN KETAPANG
Authors: Jojor Anita , Murniarti Erni 
Published: December 2023

Teknologi menjadi alat bantu yang sangat penting dalam dunia pendidikan, sehingga kemajuan teknologi harus diseimbangi dengan kompetensi pendidik terhadap penggunaannya di dalam proses pembelajaran. Penelitian ini bertujuan untuk mengkonfirmasi hasil evaluasi program pelatihan google certified educator dalam peningkatan profesionalitas guru (Studi Kasus Sekolah Kristen Ketapang). Metode penelitian menggunakan penelitian kualitatif dengan pendekatan experiential learning yaitu dengan 4 tahapan: tahap pengalaman nyata, tahap observasi refleksi, tahap konseptualisasi dan tahap implementasi. Subjek dalam penelitian ini ialah 116 guru Sekolah Kristen Ketapang mulai dari tingkat KB-TK sampai SMA. Hasil penelitian menunjukkan bahwa pelatihan google certified educator dapat meningkatkan profesionalitas guru dalam melaksanakan proses pembelajaran berbasis digital dengan didukung pengukuran dari kematangan penggunaan teknologi berbasis substitusi, augmentasi, modifikasi dan redefinisi (SAMR).
OS VALORES POLÍTICOS, JURÍDICOS E IDEOLÓGICOS DO CONSTITUCIONALISMO BRASILEIRO
Authors: Lima Amauri Ferreira de 
Published: December 2023

O artigo aborda o constitucionalismo brasileiro, destacando sua importância na consolidação das bases políticas, jurídicas e ideológicas do país. Inicialmente, apresenta uma breve análise geral dessas vertentes através da bibliografia especializada no assunto. A pesquisa foi realizada no método qualitativo e a metodologia utilizada foi em banco de teses, doutrinas e legislação e revistas renomadas, principalmente o site da SciELO. Sob o prisma político, o constitucionalismo brasileiro tem como marco a busca por uma representação democrática e pela garantia dos direitos fundamentais. Juridicamente, o artigo sublinha a forma como o Brasil adotou e adaptou princípios universais, tais como o devido processo legal, os direitos e garantias individuais e a supremacia da Constituição. Essa evolução jurídica é evidenciada pelas mudanças nas constituições ao longo dos anos, refletindo as transformações sociopolíticas e culturais do país. Do ponto de vista ideológico, o texto destaca a influência de movimentos sociais, como as Diretas Já, e o papel do constitucionalismo em consolidar uma nação comprometida com valores democráticos e com o respeito aos direitos humanos. Como resultado, o artigo reforça a relevância do constitucionalismo como instrumento de afirmação dos valores políticos, jurídicos e ideológicos no Brasil. Ao mesmo tempo, ressalta a importância de se manter um diálogo constante sobre esses valores, de forma a garantir a evolução e o aprimoramento do Estado Democrático de Direito brasileiro.
PERCEPÇÕES DE CIÊNCIAS E EDUCAÇÃO: COLABORAÇÕES DA CIÊNCIA PARA A FORMAÇÃO DE PROFESSORES
Authors: Silva Maria José da , Freitas Ednalda Morais de , Santos Maria Pricila Miranda dos 
Published: December 2023

A ciência na educação corrobora para a formação de professores, em específico do pedagogo nos seus processos de formação e repercussões na aprendizagem dos conhecimentos teórico-prático do ser professor. Este artigo objetivou compreender a história da ciência na formação de professores dos anos iniciais do ensino fundamental. Logo defende-se que os pedagogos apresentem conhecimentos acerca da Ciência da Educação, bem como, o conhecimento das práticas pedagógicas. Optamos pelo percurso teórico-metodológico embasado numa revisão bibliográfica de artigos, livros e autores que versam sobre a temática supracitada. Os procedimentos adotados para finalizar o texto em tela foram análises de explicações de autores que estão descritos no decorrer deste trabalho. Portanto, fica evidente a necessidade do conhecimento sobre ciências na educação, que irá contribuir de forma significativa na formação docente em específico destes trabalhos dos pedagogos.
Trends in polar ozone loss since 1989: potential sign of recovery in the Arctic ozone column
Authors: Pazmiño Andrea , Goutail Florence , Godin-Beekmann Sophie , Hauchecorne Alain , Pommereau Jean-Pierre , Chipperfield Martyn P. , Feng Wuhu , Lefèvre Franck , Lecouffe Audrey , Van Roozendael Michel , Jepsen Nis , Hansen Georg , Kivi Rigel , Strong Kimberly , Walker Kaley A. 
Published: December 2023

Abstract. Ozone depletion over the polar regions is monitored each year by satellite- and ground-based instruments. In this study, the vortex-averaged ozone loss over the last 3 decades is evaluated for both polar regions using the passive ozone tracer of the chemical transport model TOMCAT/SLIMCAT and total ozone observations from Système d'Analyse par Observation Zénithale (SAOZ) ground-based instruments and Multi-Sensor Reanalysis (MSR2). The passive-tracer method allows us to determine the evolution of the daily rate of column ozone destruction and the magnitude of the cumulative column loss at the end of the winter. Three metrics are used in trend analyses that aim to assess the ozone recovery rate over both polar regions: (1) the maximum ozone loss at the end of the winter, (2) the onset day of ozone loss at a specific threshold, and (3) the ozone loss residuals computed from the differences between annual ozone loss and ozone loss values regressed with respect to sunlit volume of polar stratospheric clouds (VPSCs). This latter metric is based on linear and parabolic regressions for ozone loss in the Northern Hemisphere and Southern Hemisphere, respectively. In the Antarctic, metrics 1 and 3 yield trends of −2.3 % and −2.2 % per decade for the 2000–2021 period, significant at 1 and 2 standard deviations (σ), respectively. For metric 2, various thresholds were considered at the total ozone loss values of 20 %, 25 %, 30 %, 35 %, and 40 %, all of them showing a time delay as a function of year in terms of when the threshold is reached. The trends are significant at the 2σ level and vary from 3.5 to 4.2 d per decade between the various thresholds. In the Arctic, metric 1 exhibits large interannual variability, and no significant trend is detected; this result is highly influenced by the record ozone losses in 2011 and 2020. Metric 2 is not applied in the Northern Hemisphere due to the difficulty in finding a threshold value in enough of the winters. Metric 3 provides a negative trend in Arctic ozone loss residuals with respect to the sunlit VPSC fit of −2.00 ± 0.97 (1σ) % per decade, with limited significance at the 2σ level. With such a metric, a potential quantitative detection of ozone recovery in the Arctic springtime lower stratosphere can be made.
An open-path observatory for greenhouse gases based on near-infrared Fourier transform spectroscopy
Authors: Schmitt Tobias D. , Kuhn Jonas , Kleinschek Ralph , Löw Benedikt A. , Schmitt Stefan , Cranton William , Schmidt Martina , Vardag Sanam N. , Hase Frank , Griffith David W. T. , Butz André 
Published: December 2023

Abstract. Monitoring the atmospheric concentrations of the greenhouse gases (GHG) carbon dioxide (CO2) and methane (CH4) is a key ingredient for fostering our understanding of the mechanisms behind the sources and sinks of these gases and for verifying and quantitatively attributing their anthropogenic emissions. Here, we present the instrumental setup and performance evaluation of an open-path GHG observatory in the city of Heidelberg, Germany. The observatory measures path-averaged concentrations of CO2 and CH4 along a 1.55 km path in the urban boundary layer above the city. We combine these open-path data with local in situ measurements to evaluate the representativeness of these observation types on the kilometer scale. This representativeness is necessary to accurately quantify emissions, since atmospheric models tasked with this job typically operate on kilometer-scale horizontal grids. For the operational period between 8 February and 11 July 2023, we find a precision of 2.7 ppm (0.58 %) and 18 ppb (0.89 %) for the dry-air mole fractions of CO2 (xCO2) and CH4 (xCH4) in 5 min measurements, respectively. After bias correction, the open-path measurements show excellent agreement with the local in situ data under atmospheric background conditions. Both datasets show clear signals of traffic CO2 emissions in the diurnal xCO2 cycle. However, there are particular situations, such as under southeasterly wind conditions, in which the in situ and open-path data reveal distinct differences up to 20 ppm in xCO2, most likely related to their different sensitivity to local emission and transport patterns. Our setup is based on a Bruker IFS 125HR Fourier transform spectrometer, which offers a spacious and modular design providing ample opportunities for future refinements of the technique with respect to finer spectral resolution and wider spectral coverage to provide information on gases such as carbon monoxide and nitrogen dioxide.
Thermophilisation of Afromontane forest stands demonstrated in an elevation gradient experiment
Authors: Ntirugulirwa Bonaventure , Zibera Etienne , Epaphrodite Nkuba , Manishimwe Aloysie , Nsabimana Donat , Uddling Johan , Wallin Göran 
Published: December 2023

Abstract. The response of tropical trees and tree communities to climate change is crucial for the carbon storage and biodiversity of the terrestrial biosphere. Trees in tropical montane rain forests (TMFs) are considered particularly vulnerable to climate change, but this hypothesis remains poorly evaluated due to data scarcity. To reduce the knowledge gap in the response of TMF trees to warming, we established a field experiment along a 1300–2400 m elevation gradient as a proxy for warming in Rwanda. Seedling-size trees of 20 species native to montane forests in eastern and central Africa were planted in multi-species plots at three sites along the gradient. They have overlapping distributions but primarily occur in either transitional rain forests (∼ 1600–2000 ma.s.l.) or mid-elevation TMFs (∼ 2000–3000 ma.s.l.), with both early- (ES) and late-successional (LS) species represented in each elevation origin group. Tree growth (diameter and height) and survival were monitored regularly over 2 years. We found that ES species, especially from lower elevations, grew faster at warmer sites, while several of the LS species, especially from higher elevations, did not respond or grew slower. Moreover, a warmer climate increased tree mortality in LS species, but not much in ES species. ES species with transitional rain forest origin strongly increased proportional to stand basal area at warmer sites, while TMF species declined, suggesting that lower-elevation ES species will have an advantage over higher-elevation species in a warming climate. The risk of higher-elevation and LS species of becoming outcompeted by lower-elevation and ES species due to a thermophilisation response in a warmer climate has important implications for biodiversity and carbon storage of Afromontane forests.
Warming drove the expansion of marine anoxia in the equatorial Atlantic during the Cenomanian leading up to Oceanic Anoxic Event 2
Authors: Abraham Mohd Al Farid , Naafs Bernhard David A. , Lauretano Vittoria , Sgouridis Fotis , Pancost Richard D. 
Published: December 2023

Abstract. Oceanic Anoxic Event 2 (OAE 2) (∼ 93.5 Ma) is characterized by widespread marine anoxia and elevated burial rates of organic matter. However, the factors that led to this widespread marine deoxygenation and the possible link with climatic change remain debated. Here, we report long-term biomarker records of water-column anoxia, water-column and photic zone euxinia (PZE), and sea surface temperature (SST) from Demerara Rise in the equatorial Atlantic that span 3.8 Myr of the late Cenomanian to Turonian, including OAE 2. We find that total organic carbon (TOC) content is high but variable (0.41 wt %–17 wt %) across the Cenomanian and increases with time. This long-term TOC increase coincides with a TEX86-derived SST increase from ∼ 35 to 40 ∘C as well as the episodic occurrence of 28,30-dinorhopane (DNH) and lycopane, indicating warming and expansion of the oxygen minimum zone (OMZ) predating OAE 2. Water-column euxinia persisted through much of the late Cenomanian, as indicated by the presence of C35 hopanoid thiophene but only reached the photic zone during OAE 2, as indicated by the presence of isorenieratane. Using these biomarker records, we suggest that water-column anoxia and euxinia in the equatorial Atlantic preceded OAE 2 and this deoxygenation was driven by global warming.
Transpiration rates from mature Eucalyptus grandis  ×  E. nitens clonal hybrid and Pinus elliottii plantations near the Two Streams Research Catchment, South Africa
Authors: Kaptein Nkosinathi David , Everson Colin S. , Clulow Alistair David , Toucher Michele Lynn , Germishuizen Ilaria 
Published: December 2023

Abstract. Pine plantations are the dominant species currently planted within the South African commercial forestry industry. Improvements in bio-economy markets for dissolving wood pulp products have seen an expansion in fast-growing Eucalyptus plantations due to their higher productivity rates and better pulping properties than pine. This has raised concerns regarding the expansion of Eucalyptus plantations and how they will affect water resources as they have been reported to have higher water use (quantified using transpiration rates) than pine. We measured transpiration rates (mm yr−1), diameter at breast height (quantified as quadratic mean diameter, Dq, m) and leaf area index of an 8-year-old Eucalyptus grandis × Eucalyptus nitens clonal hybrid (GN) and a 20-year-old Pinus elliottii. Transpiration rates were measured for two consecutive hydrological years (2019/20 and 2020/21) using a heat ratio sap-flow method, calibrated against a lysimeter. In the 2019/20 year, annual transpiration for P. elliottii exceeded GN by 28 %, while for the 2020/21 hydrological year, there was no significant difference between the transpiration of the two species, despite a 17 % and 21 % greater leaf area index for P. elliottii than GN in 2019/20 and 2020/21 measurement years respectively. Quadratic mean diameter increments were statistically similar (p > 0.05) in 2019/20, whereas the 2020/21 year produced significant differences (p<0.05). Tree transpiration is known to be influenced by climatic variables; therefore, a random forest regression model was used to test the level of influence between tree transpiration and climatic parameters. The soil water content, solar radiation and vapour pressure deficit were found to highly influence transpiration, suggesting these variables can be used in future water-use modelling studies. The profile water content recharge was influenced by rainfall events. After rainfall and soil profile water recharge, there was a rapid depletion of soil water by the GN trees, while the soil profile was depleted more gradually at the P. elliottii site. As a result, trees at the GN site appeared to be water stressed (reduced stem diameters and transpiration), suggesting that there was limited access to alternative water source (such as groundwater). The study concluded that previous long-term paired catchment studies indicate that eucalypts use more water than pine; however, periods of soil water stress and reduced transpiration observed in this study must be accommodated in hydrological models. Long-term total soil water balance studies are recommended in the same region to understand the long-term impact of commercial plantations on water resources.
Earth's core variability from magnetic and gravity field observations
Authors: Saraswati Anita Thea , de Viron Olivier , Mandea Mioara 
Published: December 2023

Abstract. The motions of the liquid within the Earth's outer core lead to magnetic field variations together with mass distribution changes. As the core is not accessible for direct observation, our knowledge of the Earth’s liquid core dynamics only relies on indirect information sources. Mainly generated by the core dynamics, the surface geomagnetic field provides information about the variations of the fluid motion at the top of the core. The dynamic of the fluid core is also associated with mass distribution changes inside the core and produces gravitational field time fluctuations. By applying several statistical blind source separation methods to both the gravity and magnetic field time series, we investigate the common space–time variabilities. We report several robust interannual oscillations shared by the two observation sets. Among those, a common mode of around 7 years looks very significant. Whereas the nature of the driving mechanism of the coupled variability remains unclear, the spatial and temporal properties of the common signal are compatible with a core origin.
phénoménologie de la souffrance enseignante
Authors: Fanizzi Caroline 
Published: December 2023

Cet article présente une réflexion à propos de la souffrance des professeurs des écoles au Brésil. L’examen de ce phénomène a été réalisé à partir de la définition que Paul Ricœur propose de la « souffrance », à l’occasion de sa conférence « La souffrance n’est pas la douleur ». Dans le pays étudié, la souffrance est souvent liée à la précarité de l’exercice du métier d’enseignant : les classes en sureffectifs, les bas salaires, le cumul des postes, les ressources matérielles dégradées et insuffisantes. Nous visons, cependant, à examiner les phénomènes de la souffrance à partir de la condition désignée dans nos recherches comme « précarité symbolique du métier d’enseignant ». De cette condition découle un changement dans la possibilité pour l’enseignant d’exercer ses capacités en tant qu’agent humain, ainsi que dans sa relation avec les autres. C’est donc à partir de ces deux axes que nous proposons une phénoménologie de la souffrance enseignante.
Praktik Jual Beli Emas Anggota Majelis Ta'lim Al-Hijrah Gunung Binjai Balikpapan
Authors: Masykur Marhamah , Safrina Adara Elthani , Rukmana Rukmana 
Published: December 2023

Islam groups gold and silver as usury objects. Consequently, the exchange (buying and selling) of such objects must pay attention to the provisions that have been outlined by Shari'a so as not to fall into the practice of usury. Therefore, there are special rules in the gold and silver business. The purpose of this study is to find out the practice of buying and selling gold for members of Majelis Ta'lim Al-Hijrah of Gunung Binjai, and also to find out how the practice is from the perspective of Islamic law.
This type of research is a field research that uses a descriptive qualitative analysis pattern through a phenomenological approach. The researcher chose to use this approach because through this approach the researcher tried to bring out reality naturally through provocation questions, then the research subject was left to describe all kinds of dimensions of his experience based on the phenomena that occurred.
The results of this study are that there are two methods used by members of MT al-Hijrah to trade the gold. First, the cash method (cash) at the gold shop. Second, the arisan method. The two methods used are in accordance with the Shari'ah, because they meet the legal requirements of the gold trade contract. There are two purposes of the gold transaction, namely as savings (investment) and used for jewelry.