bluuebunny/crossref_metadata_2025_split huggingface dataset:
CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway
Authors: Anderson Marsha S , Knall Cindy , Thurman Gail , Mann Don , Cusack Nancy , Johnson Gary L , Ambruso Daniel R 
Published: May 2004

AbstractCP-64131 (CP), an aminobenzazepine with cytokine-like, physiologic effects similar to granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage (GM)-CSF, increases the number of neutrophils and stimulates marrow recovery after doxirubicin ablation. CP can also function as a neutrophil agonist, like formyl-Met-leu-Phe (fMLP). In these studies, we show that CP is unique in that it stimulates the p38-mitogen-activated protein kinase (MAPK) pathway but not extracellular signal-regulated kinase (ERK)1/2 or c-jun N-terminal kinase MAPKs in human neutrophils from peripheral blood. This is in contrast to other neutrophil agonists such as fMLP, interleukin (IL)-8, or GM-CSF, which stimulate multiple MAPK pathways. Like fMLP and IL-8, CP is capable of stimulating superoxide (O2−) production, CD11b expression, and cell polarization in human neutrophils. CP-stimulated O2− production is completely dependent on p38-MAPK activation, as determined by sensitivity to the p38-MAPK inhibitor SB203580. In contrast, SB203580 only partially inhibits expression of CD11b and has no effect on cell polarization stimulated by CP. Therefore, CP treatment of neutrophils activates p38-MAPK but has effects independent of p38-MAPK activation. In human embryonic kidney 293 cells, a human kidney epithelial cell line CP stimulates p38-MAPK and modestly activates ERK1/2. The findings define CP as a novel, small molecule, which has little cellular toxicity in vitro. CP has the ability to activate specific MAPK pathways in different cell types and should prove to be an effective agonist in combination with inhibitors to study biological responses regulated by MAPKs.
P-selectin inhibition suppresses muscle regeneration following injury
Authors: Baker Wallace , Schneider Barbara A St Pierre , Kulkarni Anhurunda , Sloan Gloria , Schaub Robert , Sypek Joseph , Cannon Joseph G 
Published: May 2004

AbstractThis investigation sought to determine if P-selectin-mediated mechanisms contributed to macrophage localization in damaged muscle, an essential process for muscle regeneration. Mice were injected intravenously (i.v.) with soluble P-selectin glycoprotein ligand-1 (sPSGL-1) at 5, 50, or 200 μg/mouse or with 100 μl vehicle alone, and then, lengthening contractions were induced in hindlimb plantar-flexor muscles. The contractions caused fiber damage in soleus muscles, with maximal invasion by CD11b+ mononuclear cells at 24 h post-injury and substantial accumulation of CD11b+ mononuclear cells in the extracellular matrix up to 7 days post-injury. sPSGL-1 treatment caused a dose-dependent decrease in the number of regenerating fibers (P=0.021), as determined by developmental myosin heavy chain (dMHC) expression. This expression was reduced 93% at 7 days post-injury by the highest dose of sPSGL-1, which had no significant influence on intrafiber or extracellular accumulation of cells expressing CD11b, a general marker for phagocytic cells. Additional mice were injected i.v. with 20 μg anti-P-selectin or isotype-control immunoglobulin G and were then subjected to lengthening contractions as before. At 7 days post-injury, soleus muscles from anti-P-selectin-treated mice contained 48% fewer mononuclear cells that bound ER-BMDM1 (P=0.019), a marker for mature macrophages and dendritic cells, and 84% fewer fibers expressing dMHC (P = 0.006), compared with muscles from isotype-injected, control mice. The number of CD11b+ cells was not significantly different between groups. The results are consistent with the concept that P-selectin is involved in the recruitment, maturation, and/or activation of cells that are critical for muscle fiber regeneration.
Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination
Authors: López-Giral Sonia , Quintana Nuria E , Cabrerizo María , Alfonso-Pérez Manuel , Sala-Valdés Mónica , de Soria Valle Gómez Garcia , Fernández-Rañada José María , Fernández-Ruiz Elena , Muñoz Cecilia 
Published: May 2004

AbstractB cell neoplasms present heterogeneous patterns of lymphoid organ involvement, which may be a result of the differential expression of chemokine receptors. We found that chemokine receptor (CCR)7, CXC chemokine receptor (CXCR)4, or CXCR5, the main chemokine receptors that mediate B cell entry into secondary lymphoid tissues and their homing to T cell and B cell zones therein, were highly expressed in B malignancies with widespread involvement of lymph nodes. Conversely, those pathologies with little or no nodular dissemination showed no expression to very low levels of CCR7 and CXCR5 and low to moderate levels of CXCR4. These findings provide evidence for the role of CCR7, CXCR4, and CXCR5 in determining the pattern of lymphoid organ involvement of B tumors. Functional studies were performed on B malignancies expressing different levels of CCR7, CXCR5, and CXCR4. Multiple myeloma (MM) cells did not express CCR7 nor CXCR5 and did not migrate in response to their ligands; a moderate expression of CXCR4 on MM cells was accompanied by a migratory response to its ligand, CXCL12. By contrast, cells from B cell chronic lymphocytic leukemia (B-CLL) expressed the highest levels of these chemokine receptors and efficiently migrated in response to all ligands of CCR7, CXCR4, and CXCR5. In addition, the migration index of B-CLL cells in response to both of the CCR7 ligands correlated with the presence of clinical lymphadenopathy, thus indicating that the high expression of functional chemokine receptors justifies the widespread character of B-CLL, representing a clinical target for the control of tumor cell dissemination.
Fitting hidden semi-Markov models to breakpoint rainfall data
Authors: Sansom John , Thomson Peter 
Published: May 2004

The paper proposes a hidden semi-Markov model for breakpoint rainfall data that consist of both the times at which rain-rate changes and the steady rates between such changes. The model builds on and extends the seminal work of Ferguson (1980) on variable duration models for speech. For the rainfall data the observations are modelled as mixtures of log-normal distributions within unobserved states where the states evolve in time according to a semi-Markov process. For the latter, parametric forms need to be specified for the state transition probabilities and dwell-time distributions.Recursions for constructing the likelihood are developed and the EM algorithm used to fit the parameters of the model. The choice of dwell-time distribution is discussed with a mixture of distributions over disjoint domains providing a flexible alternative. The methods are also extended to deal with censored data. An application of the model to a large-scale bivariate dataset of breakpoint rainfall measurements at Wellington, New Zealand, is discussed.
Accuracy of Abstracts for Original Research Articles in Pharmacy Journals
Authors: Ward Leah G , Kendrach Michael G , Price Sherry O 
Published: May 2004

BACKGROUND: Accuracy of abstracts representing original research articles is imperative since these are readily available and biomedical literature readers may not have access to the full-text article. Furthermore, previous reports document discrepancies in published original research abstracts compared with the full-text article. OBJECTIVE: To determine the accuracy of abstracts for original research articles published in nationally represented, widely circulated pharmacy-specific journals ( American Journal of Health-System Pharmacy, The Annals of Pharmacotherapy, The Consultant Pharmacist, Hospital Pharmacy, Journal of the American Pharmacists Association, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy) from June 2001 through May 2002. METHODS: Outcome measures included an omission, defined as data in the abstract not located in the article. In addition, abstracts were considered deficient if these included an omission, inaccurate factual (ie, qualitative and quantitative) information presented in the abstract that differed from information contained within the text, an inconsistency in following the “Instructions for Authors” for the respective journal, or a discrepancy between the placement of text in the manuscript and a structured abstract. RESULTS: A total of 243 abstracts for original research articles were published in selected journal issues. Evaluation of these abstracts identified 60 (24.7%) abstracts containing omissions; 81 (33.3%) abstracts contained either an omission or inaccuracy. A total of 147 (60.5%) abstracts were classified as deficient. CONCLUSIONS: Results of this analysis demonstrate that improvements are needed within abstracts for original research articles published in pharmacy-specific journals. Authors and peer reviewers should analyze the abstract contents closely to ensure that the abstract accurately represents the full-text article.
The distress experienced by voice hearers is associated with the perceived relationship between the voice hearer and the voice
Authors: Vaughan Sam , Fowler David 
Published: May 2004

Objectives: To explore the relationship between distress and the perceptions that voice hearers have of their relationship with the voice they hear. We predicted that a dominant style of relating by the voice and a submissive and distancing style of relating by the voice hearer would be linked with distress.Method: Thirty people who were hearing voices took part in the study. Information was gathered about the characteristics of the voice‐hearing experience, the level of distress experienced in relation to the voice, the relationship between the voice hearer and the voice, and level of depression.Results: The tendency for the voice to relate in a dominating, insulting manner and the tendency of individuals to react with suspicion and lack of communication with the voice were uniquely associated with distress.Conclusions: Appraisals of the relationship between the voice and voice hearer made by voice hearers are associated with differing emotional responses to voices. Clinical assessments of people who have distressing voices may be enhanced by a detailed consideration of the sort of relationship that exists between the client and their voice.
Influence of Soaking on Stress-Strain Characteristics of Fly Ash
Authors: Zhou C , Yin J-H , Ming J-P 
Published: May 2004

Abstract
A series of confined uniaxial compression (oedometer) tests and triaxial compression tests were conducted to study the influence of soaking on the stress-strain characteristics of coal fly ash widely used in Mainland China. The focus was on the collapsibility of fly ash with porous structure under different conditions, such as different relative density, initial water content, stress state, stress level, consolidation stress ratio, and soaking history. Main results of the test program are presented in this paper. It is determined that soaking collapsibility of fly ash depends on the relative density, initial water content, stress state, stress level, consolidation stress ratio, and soaking history, which the fly ash has experienced. The larger the relative density, the initial water content, and the consolidation stress ratio σ′3/σ′1 are, the smaller the soaking collapsibility is. The soaking collapsibility increases with stress level, which has a strong influence on the stress-strain characteristics of the fly ash.
Effect of Compaction Conditions on the Seismic Compression of Compacted Fill Soils
Authors: Whang DH , Stewart JP , Bray JD 
Published: May 2004

Abstract
Seismic compression is defined as the accrual of contractive volumetric strains in unsaturated compacted soil during earthquake shaking. Existing seismic compression analysis procedures are based on laboratory test results for clean uniform sands, and their applicability to compacted soils with fines is unclear. We evaluate seismic compression from cyclic simple shear laboratory testing of four compacted soils having fines contents that are sufficiently large that fines control the soil behavior, but possessing varying levels of fines plasticity. Each soil material is compacted to a range of formation dry densities and degrees-of-saturation. The test results show that seismic compression susceptibility decreases with increasing density and decreasing shear strain amplitude. Saturation is also found to be important for soils with moderately plastic fines (plasticity index, PI ≈ 15), but relatively unimportant for soils with low plasticity fines (PI ≈ 2) across the range of saturations tested (≥54%). The saturation effect appears to be linked to the presence or lack of presence of a clod structure in the soil, the clod structure being most pronounced in plastic soils compacted dry of the line-of-optimums or at low densities. Comparisons of test results for soils with and without low- to moderately-plastic fines suggest that fines can decrease the seismic compression potential relative to clean sands.
Critical Review of Through-Wall Attenuation of Mechanical Properties in RPV Steels
Authors: English CA , Server WL , Rosinski ST 
Published: May 2004

Abstract
This paper reviews the current state of knowledge on attenuation of damage parameters in reactor pressure vessels (RPVs). There are two methods for evaluating attenuation of properties through a reactor pressure vessel wall. The first is by direct measurement of the change in mechanical properties from decommissioned RPV sections or from simulated RPV wall experiments. It is shown that, although this approach is appealing, issues associated with knowledge of the start-of-life properties throughout the vessel wall sample and material property data scatter have made past measurements non-definitive in establishing attenuation changes. There is a need for further data on the direct measurement of attenuation, and an experiment is described, that is planned in 2002 under IAEA sponsorship. An alternative method for evaluating embrittlement is the use of a neutron damage exposure parameter and attenuation model coupled with an embrittlement correlation developed from surveillance capsule testing. The significant change in neutron flux spectrum when neutrons are attenuated through the RPV wall defines the need for a suitable neutron exposure damage parameter. The best available neutron exposure damage parameter is dpa. It is shown that plant-specific calculation of dpa through the RPV wall is the best method to be used for the neutron exposure. However, it can lead to slightly less attenuated values for damage at ¼-T and ¾-T for the vessel, as compared to using the simple exponential model quoted in Regulatory Guide 1.99, Rev. 2. Finally it is concluded that when using a surveillance correlation model to predict the attenuation of mechanical properties through the RPV wall, the use of a mechanistically guided model appears to be more appropriate than the embrittlement correlation provided in Regulatory Guide 1.99, Revision 2.
Mechanical and Structural Property Changes of Monolithic SiC and Advanced SiC/SiC Composites due to Low Temperature He+-Ion Irradiation and Post-Irradiation High Temperature Annealing
Authors: Nogami S , Miwa S , Hasegawa A , Abe K 
Published: May 2004

Abstract
The hardness and elastic modulus of monolithic β-SiC and advanced SiC/SiC composites irradiated to He-concentrations of from 1000 to 20 000 at.ppm at a temperature below 100°C were investigated. Changes in the hardness and elastic modulus were correlated with He release behavior and with irradiation-induced microstructural changes and swelling. The hardness and elastic modulus of the irradiated specimens decreased with He concentration. Amorphized regions were observed in the He-irradiated monolithic β-SiC. The mechanical property changes likely were due to irradiation-induced amorphization. By the annealing at 1200°C, nearly full recovery was achieved. He release peaks from the pyrolitic graphite, monolithic SiC, and the SiC/SiC composites at 250, 700, 1000, and 1150°C, were identified. The correlation between the mechanical property and microstructural changes and the He release behavior are discussed.
Dependence of Re-embrittlement Rate After Annealing on the Copper, Nickel and Phosphorus Contents in Model Alloys
Authors: Valo M , Ehrnstén U , Kohopää J , Debarberis L , Kryukov A , Rintamaa R 
Published: May 2004

Abstract
Irradiation embrittlement rate as well as the re-embrittlement rate after annealing of pressure vessel steels can in general be described by the copper, phosphorus and nickel contents of the materials. In the current study embrittlement and re-embrittlement rate of 32 different model alloys were measured using sub-size CH-V specimens of dimensions 3 × 4 × 27 mm. The impurity and alloy elements of the model alloys were varied within the limits Cu: 0−1.0 wt-%, P = 0−0.040 wt-% and Ni: 0−2.0 wt-% relatively evenly. The specimens were originally irradiated in the high flux reactor in Petten into a neutron fluence of 0.3×1019n/cm2, E &gt;1 MeV and re-irradiated after the annealing treatment in the Loviisa power reactor into a fluence of 1.0 × 1019n/cm2, E &gt; 1 MeV. In the paper the irradiation and re-irradiation embrittlement rate has been modeled based on the Cu, P and Ni contents of the alloys. Re-irradiation rate was found to be clearly lower than the original irradiation rate except for small corner in the element space, i.e., no nickel, low copper and high phosphorus alloys. Phosphorus coefficient in the re-irradiation shift function is relatively two times higher than in the original irradiation shift function. Many of the alloys in the IAI-condition show intergranular type fracture (IGF). However, the effect of the change of the fracture mode from cleavage to IGF on transition temperature shift remains open. The dependence of irradiation embrittlement, annealing and re-embrittlement behavior on the copper, phosphorus and nickel contents is still not solved, one reason being the relatively limited variation of the key elements in the materials. Model alloys offer a good variation matrix of the elements even, if the measured data cannot be directly applied to real steels.
“Homicide by Heart Attack” Revisited
Authors: Turner SA , Barnard JJ , Spotswood SD , Prahlow JA 
Published: May 2004

Abstract
The sudden death of a person caused by an arrhythmia that is induced by physical and/or emotional stress provoked by the criminal activity of another person is sometimes referred to as “homicide by heart attack.” Published criteria for such an event relate to situations where no physical contact occurs between the perpetrator and the victim. Situations involving physical contact, but with absence of lethal injuries, are frequently treated in a similar fashion by forensic pathologists. Herein, we propose a set of modified criteria, which include cases where physical contact has occurred. Five examples of so-called “homicide by heart attack” are presented, including a 40-year-old man who was struck in the head with a wooden statue, a 74-year-old man who was punched in the jaw by a robber, a 66-year-old woman who was startled awake by a home-intruder, a 67-year-old woman who struggled with a would-be purse-snatcher in a parking lot, and a 52-year-old man who was in a physical altercation with a younger man. In each instance, autopsy revealed the presence of severe, underlying heart disease, as well as absence of lethal injuries. In each case, investigative information was such that the emotional and/or physical stress associated with the criminal activity of another individual was deemed contributory to the death. The presumed mechanism of death in each case was a cardiac dysrhythmia related to underlying heart disease, but initiated by the emotional and/or physical stress.
Virtopsy—Fatal Motor Vehicle Accident with Head Injury
Authors: Aghayev E , Thali M , Jackowski C , Sonnenschein M , Yen K , Vock P , Dirnhofer R 
Published: May 2004

AbstractA man wearing no protective helmet was struck by a motor vehicle while riding a bicycle. He was loaded on his left side, and the impact point of his head was his occiput on the car roof girder. He was immediately transported to the general hospital, where he passed away. Postmortem examination using multi-slice computed tomography (MSCT) revealed an extensively comminuted fracture of the posterior part and the base of the skull. Observed were deep direct and contrecoup brain bruises, with the independent fractures of the roof of the both orbits. Massive subdural and subarachnoidal hemorrhage with cerebral edema and shifting of the mid-line towards left side were also detected. MSCT and autopsy results were compared and the body injuries were correlated to vehicle damages. In conclusion, postmortem imaging is a good forensic visualization tool with great potential for documentation and examination of body injuries and pathology.
Sudden Death Associated with Food and Exercise
Authors: Flannagan LM , Wolf BC 
Published: May 2004

Abstract
Exercised-induced anaphylaxis occurs in conjunction with significant physical exertion. Anaphylaxis occurring when an individual exercises within a few hours of ingesting a particular food is an unusual variant. Cardiovascular symptoms can be the sole manifestation of exerciseinduced food allergies, in which case death may mimic sudden cardiac death during physical exertion due to other pathologic causes. We report the sudden and unexpected death of an individual following the ingestion of hazelnuts and almonds, to which the individual was not previously known to be allergic. The decedent collapsed during vigorous dancing. The death was not associated with cutaneous or laryngeal manifestations of anaphylaxis. Awareness of the variable manifestations of food-precipitated anaphylaxis is necessary to correctly establish the diagnosis. An elevated serum tryptase level may be indicative of an allergic reaction, and allergen-specific IgE levels may be used to confirm the particular antigen.
Psychiatric and Neurological Characteristics of Murder Defendants Referred for Pretrial Evaluation
Authors: Frierson RF , Finkenbine RD 
Published: May 2004

Abstract
After literature review, this paper presents the largest study to date (n = 270) of psychiatric and neurological characteristics of accused murderers in the United States. This retrospective record review of pretrial detainees undergoing competency to stand trial and criminal responsibility evaluations examined demographic characteristics, psychiatric diagnosis, substance use patterns, Intelligence Quotient (IQ), and results of electroencephalogram (EEG), neuroimaging (MRI or CT) and neurological examination. Substance use and mood/adjustment disorders were common. Neuroimaging was abnormal in 18% of subjects and was associated with lower Performance IQ. EEG and neurological exam findings were not associated with measured cognitive impairment. While 16% of subjects had a FS IQ &lt; 70, only 6% were diagnosed with mental retardation. Subjects with a psychotic disorder (p = 0.001) or an anxiety disorder (p = 0.005) were more likely to use a knife than other subjects in the study. Violence risk assessment in these patients must not only involve inquiry about firearm availability.