bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reservoir damage mechanism and “Double protection” drilling fluid of tight sandstone gas reservoir in central SiChuan Basin
Authors: Fan Yu , Huang Weian , Guo Jianhua , Bai Ruiyu , Lin Jiang , Wang Zengbao 
Published: January 2024

Abstract
It is very important to clarify the reservoir damage characteristics and damage characteristics and damage mechanism of tight sandstone gas reservoirs in Jinhua-Zhongtai mountain area of central SiChuan Basin, and put forward the technical countermeasures of “Double protection” drilling fluid to protect the reservoir and the environment, which is very important for the efficient well construction in this area. Through X-ray diffraction, scanning electron microscopy, casting thin sections and other testing methods, the mineral composition and microstructure characteristics of the block were analyzed, and the potential damage factors of the reservoir were clarified. Based on the sensitivity evaluation, it was revealed that the overall sensitivity damage of the block was weak. The main damage type was salt-sensitive damage, and the critical salinity was 9472.5 mg/L. On the basis of the environmental protection drilling fluid system used in this block, the surfactant which can effectively prevent gas invasion and reduce surface tension is selected, and the “Double protection” drilling fluid system is constructed. Through comprehensive performance test and reservoir protection performance evaluation, the core permeability damage rate of the optimized drilling fluid system is reduced from 88.77–18.66%, and the cuttings recovery rate is increased to more than 66%, and the cuttings expansion rate is reduced to less than 3.2%, which can effectively solve the problem of reservoir damage in drilling in Jinhua-Zhongtai mountain block in central Sichuan.
Numerical analysis of flow past five inline square cylinders at various gap spacing with Strouhal number
Authors: Manzoor raheela , perveen Sajida , Akhtar Yasmeen , Panezai Neelam 
Published: January 2024

Abstract
A two dimensional numerical study is carried out for flow past five inline square cylinders of similar size ‘D’ at Re = 150 for studding flow behavior. The gap spacing (g) between the cylinders is varied from g = 0.25–5. The flow structure mechanism is analyzed in terms of vorticity contour visualization, time-history analysis of drag and lift coefficients and physical parameters. Under the effect of gap spacing, four distinct flow modes are identified. These are, i). Shear layer reattachment flow mode, ii). Semi-developed irregular vortex shedding flow mode, iii). Fully-developed two rows vortex shedding flow mode and iv). Two rows single bluff body flow mode for cylinders C1-C5. In Force Statistics, the values of Cdmean, Cdrms, Clrms and St are calculated. The mean drag coefficient represents mixed trend by increasing the values of gap spacing for cylinders C3, C4 and C5. The maximum value of Cdmean is found at g = 5 for cylinder C1, that is 1.4594, while the minimum value of Cdmean is for cylinder C3 at g = 0.25. There may also observed some negative values of Cdmean for cylinder C2 at g = 0.25–2.25 and for cylinder C3 at g = 0.25–1.25 due to effect of thrust. Furthermore, St shows increasing behavior at small and large gap spacing i.e = 0.25–0.75 and = 1.5-5. While decreasing behavior at moderate gap spacing. The greatest value of Strouhal number is examined at g = 5 for cylinder C5, i.e 0.1521.
N-acetylaspartate from fat cells regulates postprandial body temperature
Authors: Felix Jessica , Saha Pradip , de Groot Evelyn , Tan Lin , Sharp Robert , Anaya Elizabeth , Li Yafang , Quang Holly , Saidi Nooshin , Abushamat Layla , Ballantyne Christie , Amos Christopher , Lorenzi Philip , Klein Samuel , Gao Xia , Hartig Sean 
Published: January 2024

Abstract
N-acetylaspartate (NAA), the brain's second most abundant metabolite, provides essential substrates for myelination through its hydrolysis. However, activities and physiological roles of NAA in other tissues remain unknown. Here, we show aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs systemic NAA levels for postprandial body temperature regulation. Proteomics and mass spectrometry revealed NAA accumulation in WAT of Aspa knockout mice stimulated the pentose phosphate pathway and pyrimidine production. Stable isotope tracing confirmed higher incorporation of glucose-derived carbon into pyrimidine metabolites in Aspa knockout cells. Additionally, serum NAA positively correlates with the pyrimidine intermediate orotidine and this relationship predicted lower body mass index in humans. Using whole-body and tissue-specific knockout mouse models, we demonstrate that fat cells provided plasma NAA and suppressed postprandial body temperature elevation. Furthermore, exogenous NAA supplementation reduced body temperature. Our study unveils WAT-derived NAA as an endocrine regulator of postprandial body temperature and physiological homeostasis.
Developments in the molecular basis of heterosis to evaluate the quality and yield production of F1 garden peas using novel genetic resources
Authors: Aman Faiza , Basit Abdul , Ara Neelam , Shah Syed Mehar Ali , Khan Waleed , Khan Ayesha , Shah Syed Tanveer 
Published: January 2024

Abstract
The utilization of novel germplasm in hybridization programs presents a valuable opportunity for crop breeders to explore the potential of heterosis in key agronomic traits. This study aimed to evaluate the extent of heterosis for maturity and yield characteristics by employing new pea accessions in hybridization. The experimental material consisted of 51 F1 pea hybrids obtained through crossbreeding of parents in all possible combinations. The F1 cross UAP-47×UAP-29 demonstrated the highest metrics for seeds per pod (12.3), 100-green seed weight (g), 100-green pod weight (g), and green pod yield (tons ha− 1). Similarly, the F1 hybrids Green Gold×UAP-47 and UAP-29×UAP-47 exhibited the greatest pod length (cm) and pods per plant (66.0), respectively. The most noteworthy negative better-parent heterosis (-30.9%) for days to first picking was evident in the UAP-29×Leena Pak cross. Meanwhile, the F1 cross UAP-7×UAP-35 showcased the highest positive better-parent heterosis (%) for pods per plant. UAP-29×UAP-47 displayed the highest better-parent heterosis (%) for pod length. The F1 hybrid Leena Pak×UAP-31 exhibited significantly better parent heterosis (%) for seeds per pod. Similarly, the cross UAP-32×UAP-7 displayed remarkably better parent heterosis (%) for 100-green seed weight. For 100-green pod weight, the Leena Pak×UAP-31 cross demonstrated the highest better-parent heterosis (%). The cross combination UAP-47×UAP-29 showcased the maximum better-parent heterosis for green pod yield (%). The segregating generations from crosses like UAP-29×Leena Pak for early maturity and those such as UAP-29×UAP-47, UAP 47×UAP-29, UAP-7×UAP-35, Leena Pak×UAP-31, and UAP-32×UAP-7 for yield traits could be advanced for the development of early maturing and high-yielding pea cultivars.
Predictive Value of ICU Patients' Mortality Based on Serum Ionized Ca Rather Than Total Ca in Acute Ischemic Stroke: Insights from MIMIC-IV Database Analysis
Authors: Wu Caijiao , Li Xiaorong , Li Jiaxing , Huo Ruiling , zhao huihan , Ying Yanping 
Published: January 2024

Abstract
Background
While serum Ca has proven to be a reliable predictor of mortality across various diseases, its connection with the clinical outcomes of ischemic stroke (IS) remains inconclusive. Our research aimed to explore the relationships between serum total Ca (tCa) and serum ionized Ca (iCa) and mortality among acute IS (AIS) patients.
Methods
We gathered data from 1773 AIS patients in the Medical Information Mart for Intensive Care Database IV, including baseline demographic data, comorbidities, vital signs, laboratory-based data, and scoring systems. Endpoints for the study encompassed 30-d, 90-d, and 365-d all-cause mortalities. Employing restricted cubic spline Cox regression, we explored potential nonlinear relationships between admission serum iCa and tCa levels and mortality. Participants were categorized into four groups based on serum iCa and tCa quartiles. Multivariable Cox regression analysis was then conducted to evaluate the independent association of iCa and tCa quartiles with all-cause mortality.
Results
The restricted cubic spline revealed a U-shaped association between iCa and 30-d and 90-d mortality (P < 0.05), while the relationship between iCa and 365-d mortality was linear (P < 0.05). After adjusting for confounders, multivariable Cox analysis demonstrated that the lowest serum iCa level quartile was independently associated with increased risks of 30-d, 90-d, and 365-d mortality. Similarly, the highest serum iCa level quartile was independently associated with increased risks of 30-d and 90-d mortality, but not 365-d mortality. Notably, serum tCa level showed no association with increased risks of 30-d, 90-d, and 365-d mortality.
Conclusions
Our findings suggest that serum iCa, rather than tCa, is linked to ischemic stroke prognosis. Both high and low serum iCa levels are associated with poor short-term prognosis, while only low serum iCa is associated with poor long-term prognosis in AIS patients.
Concurrent Scaling: Evaluating AWS Lambda Performance through Load Testing
Authors: Balakrishna Balasubrahmanya 
Published: January 2024

Abstract
In the dynamic environment of serverless computing, efficient concurrency management and reasonable utilization of load testing techniques closely correlate with performance improvement. This paper, aiming to offer practitioners practical insights and contribute to the theory of serverless architectures, intends to illuminate the intricate connection between concurrency settings and load testing results within AWS Lambda. The paper thoroughly explores load testing and concurrency control in AWS Lambda. We specified a range of concurrency settings, including provisioned and unreserved, and meticulously selected representative Lambda functions. We subjected these functions to diverse simulated workloads using industry-standard load testing methods. We methodically measured and recorded performance metrics, including response times, throughput, and resource consumption, to identify significant patterns and correlations. The article shows discrete performance quirks associated with various concurrency settings by exposing necessary trade-offs and optimization techniques. In addition to providing helpful advice for developers and architects, this research advances our theoretical knowledge of how concurrency affects the performance of serverless functions. Focusing on the unique features of AWS Lambda, the need for customized load-testing approaches is emphasized, offering practitioners practical advice on how to improve the efficiency and scalability of their serverless apps. This article uniquely enriches the confluence of theory, practice, and policy in serverless computing. Defining the complex relationship between concurrency and load testing and providing a platform for future research enhances theoretical underpinnings. The results provide developers and architects with explicit guidelines on configuring concurrency settings to meet workload needs. Additionally, the study supports a sophisticated approach to load testing and concurrency control in the larger context of cloud computing, which adds to policy discussions surrounding serverless best practices.
Environmental assessment by vulnerability analysis of water intended for human consumption in urban environments using GIS methods: Case of the N'djili River (Kinshasa/DR Congo)
Authors: MUFUNGIZI Innocent , LOOLA Ruben , AKILIMALI Aymar 
Published: January 2024

Abstract
The Water Distribution Administration of the Democratic Republic of Congo (REGIDESO) continues to face numerous problems linked in particular to unregulated human activities throughout the river in general and in particular around the watershed of the N River 'djili. Domestic and industrial activities, agricultural activities, commercial activities, and road transport contribute to the pollution of the N'djili River and groundwater. Contaminated water constitutes a health danger for the population because it accentuates water-borne diseases such as cholera, diarrhea, and even malaria, which caused a total of 619,000 deaths in Africa in 2021. It is with this motivation that we are given the task of carrying out an environmental study to analyze the vulnerability of water in this area in order to propose a Water Security Plan (PSG). During the environmental investigation, we listed several sources of water contamination, mainly chemicals used in agricultural areas to increase profitability, domestic wastewater, industrial wastewater, and feces. Subsequently, we calculated the water protection perimeters of the N'djili River and the drilling observed in the study area using geographic information systems (GIS) techniques. It was noted that the immediate protection perimeter is occupied by activities likely to pollute water; this is the case for the close protection perimeter. To combat these problems, the government of the Democratic Republic of Congo must put in place a solid water safety plan, which will help combat several consequences that these problems present for the health of the population.
A Metanalysis of Burden of Stroke for HIV population in Africa: Current and Future perspectives
Authors: Zulu Francis , Webster Munengo , Sandra Situmbeko , Musonda Banda , Mavis Bwalya , Moonga Mirriam , Bwalya Nsofwa , Spelile Siamulandabala , Patience Phiri Mwanida , Shamapongo Shambana 
Published: January 2024

Abstract
Objective
Information on the current burden of stroke for HIV population in Africa is limited. The aim of this review was to comprehensively examine the current and future burden of stroke for HIV population in Africa. Methods: We systematically reviewed the available literature (PubMed) from January 1960 to September 2022 on stroke for HIV population in Africa. Percentage change in age-adjusted stroke incidence among HIV population in Africa was obtained from peer reviewed articles and entered in a data capturing tool called systematic literature HIV and Stroke review summary table. Results: Studies revealed that the prevalence of stroke among HIV population in Africa varies from country to country with the lowest being 2.3% and the highest 18%.
Conclusion
While the available study data and evidence are limited, the burden of stroke for HIV population in Africa appears to be increasing and more significantly among the young population of average age 46 years.
Successive Isolation, Identification and Antimicrobial Susceptibility Pattern of Bacteria Involved in the Processing of two Traditionally Fermented foods (Okpehe and Ogiri)
Authors: Ogbu J.C. , Ugoh S.C. 
Published: January 2024

Abstract
This research focuses on the Successive isolation and Antimicrobial Susceptibility Pattern of bacteria involved in the processing of two traditionally fermented foods (Okpehe and Ogiri). Successive Isolation of the bacteria was done on the 24 hour, 48 hour, 72 hour, 96 hour and 120 hour of the Fermented samples by innoculating the samples on Nutrient Agar, MacConkey Agar and Mannitol Salt Agar. Some Biochemical tests (Gram staining, citrate, Oxidase and Catalase) was done and the organisms obtained were Staphylococcus aureus, Escherichia coli and Staphylococcus epidermis.
WITHDRAWN: The economic effect of sex and germinated sprout feed on the growth performance of new hybrid broiler chickens for environmental adaptation in Egypt
Authors: Arafa Abdelsatar 
Published: January 2024

Abstract

In this study, a total of 360 one-day-old birds (180 males and 180 females) of a new hybrid broiler (WINZY line 105) were raised to 8 weeks of age. Birds were randomly taken to be similar in body weight (33.9 ± 0.58) and divided into four groups (90 birds in each group) in three replicates (30 birds/replicate). The experimental groups involved a 2X 2 factorial arrangement, two sex groups (male (M) and female (F)), and two types of rations (basal diet from one day up to 56 days and basal diet plus germinated sprouts from 28 to 56 days of age). The birds were reared in controlled, semi-closed houses in winter, aiming to simulate the effects of sex and ration type on productive, physiological and economic efficiency for environmental adaptation. Sex is the main determinant of broiler performance. Compared with females, males had significantly (P≤01) greater body weight, body weight gain, feed intake, feed conversion, carcass weight and economic efficiency. Body weight, feed intake and feed conversion gain were improved for the chicks fed a basal diet plus germinated sprout feed in comparison to those of the other groups fed only basic rations. The carcass yield, abdominal fat percentage, total antioxidant capacity, cholesterol and low-density lipoprotein content were greater for males fed a basal diet plus germinated sprouts than for those in the other groups, and the net return economic efficiency percentage was also greater. In conclusion, the use of germinated sprout feed improved birds' productivity and physiologic and economic efficiency, especially in males. This work highlighted the importance of breeding characteristics and feeding type on the growth performance of broilers and will help to select and improve their traits against environmental stresses.
Efficient separation of cadmium from cobalt-rich solutions using cyanex301 and P204/P507
Authors: Qian Zhen , Li Chongyang , He Limin , Chen Hufei , Peng Yanmei , Shi Qilong , Xiong Xueliang , Xia Xinbing , Wang Changhong 
Published: January 2024

Abstract
The presence of cadmium (Cd) in ternary batteries is a known detriment to both their service longevity and cycling performance. Traditional methods for reducing Cd levels in cobalt (Co) sulfate solutions can be effective but often result in significant losses of Co. This study introduces an enhanced dual-extractant system that combines 5% (V/V) di-2-ethylhexyl phosphoric acid (P204) with 5% (V/V) bis (2,4,4-trimethylpentyl) dithiophosphinic acid (Cyanex301) to effectively lower Cd content without substantial Co depletion. Conducted at a pH of 1.8 with a 1:1(V/V) organic-to-aqueous phase ratioat 25 °C for 10 minutes, our approach achieved a 99.99% extraction efficiency for Cd and limited Co extraction to just 0.53%. Subsequent stripping processes utilized 1 M sulfuric acid and 6 M hydrochloric acid to recover 87.13% of Co and 95.11% of Cd. An efficient process roadmap operated at optimized condition was constructed for plant-wide treatment of the cobalt sulfate solution containing Cd. The innovative results hold the potential to accelerate advancements in secondary resource recycling, especially Cd and Co.
The match between higher education skill supply and employers’ skill needs in Ethiopia
Authors: Teshome Asmera 
Published: January 2024

Abstract
The purpose of this study investigated the match between higher education skill supply and employers’ skill needs, with a special focus on engineering graduates in Ethiopia. Using an embedded mixed method design, the study analyzed both primary and secondary data on the match between higher education supply and employers needs for discipline-specific, technical, interpersonal, and generic skills. 275 research participants recruited from employees, employers, higher education instructors, and decision-makers took part in the study. The findings of the study revealed that higher learning institutes moderately equip graduates with discipline-specific skills, technical skills, interpersonal skills, and generic skills, while employers’ need for these skills is high. These indicate existence of a significant mismatch between higher education skill supply and employers’ needs, which was higher for technical and generic skills than interpersonal and discipline-specific academic skills. Such mismatch between higher education skill supply and employers’ skill needs negatively affect economic performance and social security through increasing rate of graduates’ unemployment. To mitigate such problems, higher learning institutes could conduct real employers’ needs assessments before preparing training curricula and need to update training styles and contents accordingly. The skills employees acquire at work, factors contributing to the mismatch between skill supply and employers’ needs, and impacts of skill mismatch could be future research areas.
Exploring Teacher Efficacy in Integrating Robotics and Concept-Based Approach for Teaching Chemistry Using the Periodic Table
Authors: MHLONGO THABO 
Published: January 2024

Abstract
This study investigates the efficacy of integrating robotics and a concept-based approach in teaching chemistry, with a focus on the periodic table. Utilizing Bandura's social-cognitive theory and situational efficacy, a multiple-case study design involves four purposefully selected chemistry teachers. Data, gathered through classroom observations and semi-structured interviews, highlights how teachers' conceptions, beliefs, and characteristics shape their integration of robotics in chemistry education. Positive outcomes include heightened learner interest, improved understanding, and increased motivation. The study emphasizes the value of interdisciplinary learning, inquiry-based activities, and continuous professional development for successful integration. The findings provide insights for enhancing teaching efficacy and improving learning outcomes in chemistry education, guiding future research and professional development initiatives.
Cord Blood Cortisol Level - A Possible Predictor for Respiratory Distress
Syndrome in Preterm Neonates
Authors: John Thomas Anup , Gunasekaran Dhandapany , Venkatesh Chandrasekaran , Chhavi Nanda , Palanisamy Soundararajan 
Published: January 2024

Background::
Respiratory Distress Syndrome (RDS) is a leading cause of death in premature
infants. There are different clinical/ biochemical markers associated with the RDS. One of
the potential biochemical markers is cortisol in cord blood.

Purpose::
This study aims to correlate cortisol levels in preterm neonates with RDS and to establish
whether cord blood cortisol is a reliable predictor for RDS.

Materials and Methods::
This prospective analytical study was conducted in a tertiary care hospital
over nine months among fifty preterm neonates. Data were collected using proforma, and cord
blood was collected at the time of delivery. Cortisol levels were compared and correlated to the development
of RDS.

Results and Discussion:
The mean ± SD cord blood cortisol level among preterm neonates was
5.97 ± 2.74 (SD) μg/dl. The levels were higher in neonates whose mothers received antenatal
steroids and were significantly lower (2.86 ± 1.66 μg/dl) in those who developed RDS. Association
between cord blood cortisol level and RDS was found with an odds ratio of 57.4, which was
statistically significant.
The percentage of babies developing RDS in mothers not covered with antenatal steroids was significantly
higher than those covered (p-value is 0.000).
The mean cord blood cortisol levels were exceptionally low (1.89 μg/dl) in neonates who expired
compared to those who survived (7.02 μg/dl).

Conclusion::
There is an association between cord blood cortisol levels and RDS. Hence, Cord
blood cortisol levels may be used to predict RDS and help initiate early treatment, thus preventing
mortality and morbidity.