bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Faktor Kecelakaan Kerja Pada Rumah Industri Kampung Tahu Kota Kediri
Authors: Semnasti Titin Trimintarsih , Semnasti Muhammad Hakulyakien Dimyathi , Semnasti Kinanti Resmi Hayati , Semnasti Nur Rahmawati 
Published: November 2023

Terdapat 30 rumah industri di Kampung Tahu Kota Kediri. Kebutuhan produksi kedelai 2 hingga 4 kuintal per hari. Suhu panas dan ruang yang terbatas membuat pekerja tidak peduli terhadap penggunaan Alat Pelindung Diri. Hal ini tentu menjadi rentan terjadi kecelakaan kerja yang disebabkan oleh manusia dan lingkungannya. Penelitian ini termasuk penelitian observasional, t case study dan analisis deskriptif. Adapun populasi sebanyak 234 orang. Sampel teknik purposive sampling dengan kriteria sampel yaitu pekerja yang terlibat kecelakaan kerja terjadi. Penelitian dilakukan bulan Agustus, pengolahan data September 2023. Pengambilan data Agustus dan September 2023. Variabel penelitian frequency rate, severity rate , incidence rate serta faktor yang mempengaruhi kecelakan meliputi immediati cause, faktor basic cause dan faktor lack of control. Cara pengumpulan data dengan wawancara dan pengumpulan data sekunder. Angka kecelakaan kerja nilai Frequency Rate (FR), Severity Rate (SR) dan Incidence Rate (IR). Nilai Frequency Rate (FR) pada tahun 2020–2022 adalah 476,82. Angka FR pada tahun 2020-2023 berpengaruh pada angka severity rate (SR). Severity Rate (SR) pada proses produksi tahu pada 2020-2022 adalah 0, disebabkan kejadian kecelakaan pada proses produksi berakibat Lost Time Injuries (LTI) yaitu kecelakaan kerja yang tidak sampai menimbulkan jam kerja hilang lebih dari 2 × 24 jam.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 6 No. 3 August 2023
Authors: Borneo J Pharm Chief Editor of 
Published: November 2023

Assalamu’alaikum Wr. Wb.
Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published at August 2023. This edition contains ten articles: Pharmacology-Toxicology, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Microbiology Pharmacy, and Clinical-Community Pharmacy. This edition includes writings from five countries: Cyprus, Indonesia, Malaysia, Nigeria, and the Democratic Republic of the Congo. The authors come from several institutions, including University of Maiduguri, Cyprus International University, Newcastle University Medicine Malaysia, Ahmadu Bello University, Adamawa State Polytechnic, Modibbo Adama University, Politeknik ATI Padang, Universitas Andalas, Politeknik Teknologi Kimia Industri Medan, Université de Kinshasa, Universitas Airlangga, Universitas Ahmad Dahlan, Universitas Islam Negeri Maulana Malik Ibrahim, Universitas Udayana, Institut Teknologi dan Kesehatan Bali, Sekolah Tinggi Farmasi Mahaganesha, and Universitas Gadjah Mada.
Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors, could re-participate for the publication in the next edition on November 2023.
Wassalamu’alaikum Wr. Wb.
THEORETICAL BASICS OF MONITORING THE CONDITION OF THE ELECTRODES OF CHEMICAL CURRENT SOURCES BY THE METHOD OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY
Authors: Ryabokin Oleg 
Published: November 2023

On the basis of the conducted critical review of modern physical models of the porous electrode, it сan be stated that under the conditions of non-uniform mass transfer taking into account the depth of the electrode, it is possible not only to develop new porous electrodes for a certain application, but also to control the state of electrochemical systems as a whole using the non-destructive method of electrochemical impedance spectroscopy. The presence of a macroscopic model of porous electrode allows one to use the integration of parameters over the surface of the electrode and obtain the average values of current, resistance and capacity within the electrode using the method of averaging in the volume ele­ment within the electrode, where porosity is the volume fraction of the void within the element, which is filled with electrolyte solution. This is the theoretical basis for using electrochemical impedance spectroscopy to assess the state of electrodes in electrochemical current sources. To take into account the influence of the aqueous electrolyte, it is possible to use a model taking into account the area of the effective wetted surface, which makes it possib­le to relate the wetting of the electrode pores with the electrolyte solution to the change in electrical conductivity and polarization of the electrode surface. In this case, when usingelectrochemical impedance spectroscopy, it is possible to obtain information about the following changes in primary current sources: 1– the effect of temperature, which leads to a decrease in the areas of the electrode wetted by the electrolyte, which affect the value of the capacity of the DEL, 2 – chemical processes that lead to the destruction of hydrophilic pores and pores with hydrophilic-hydrophobic walls, an increase in the hydrophobic component on the surface of the electrode, 3 – mechanical destruction of the electrodes. The use of models that take into account the geometry of pores makes it possible to obtain correct data for the analysis of the porous surface in the presence of an electrolyte and in cases of gas phase adsorption in presence of closed pores, as well as to use the value of the capacity on the surface of electrodes to assess the state of their performance.
Efficacy of treatment of patients with psoriasis with anxiety and depression with interleukin‑23 inhibitor guselkumab
Authors: Vladimirova I. S. , Kruglova L. S. , Sviridov O. V. , Samushiya M. A. 
Published: November 2023

Psoriasis is a chronic immune-mediated systemic disease that is closely associated with comorbid depression and anxiety disorders. Today, a new direction of therapy is represented by biological therapy. One of the effective and safe drugs is the IL‑23 inhibitor guselkumab.Purpose of the study. To study the effectiveness of therapy with the interleukin‑23 inhibitor (guselkumab) and the dynamics of indicators of symptoms of anxiety and depression in patients with moderate and severe psoriasis.Material and methods. A retrospective study of 25 patients diagnosed with widespread vulgar psoriasis was conducted. Initial indicators were assessed using the PASI, BSA, sPGA, DLQI, and VAS (itching scale) indices. Anxiety and depression scores were assessed using the HADS and GAD‑7 scales. All patients received treatment with guselkumab according to the standard regimen. The effectiveness of therapy was assessed by the dynamics of PASI, BSA, sPGA, DLQI, VAS, HADS, GAD‑7 indicators after 12 weeks of therapy with the interleukin‑23 inhibitor (guselkumab).Results. Biological therapy with guselkumab resulted in significant reductions in all parameters at 12 weeks for each patient (p < 0.0001). Only improvement in PASI was significantly correlated with lower depression and anxiety scores (p < 0.0050), whereas decrease in DLQI was not (p > 0.9550).Conclusions. Biological therapy with the interleukin‑23 inhibitor guselkumab is highly effective in both reducing disease severity and alleviating symptoms of depression and anxiety in psoriasis.
Vulvoscopy: anachronism or a time-tested method?
Authors: Ignatovsky A. V. 
Published: November 2023

Objective. Due to the growing number of patients with various diseases of the vulva, there is a need to evaluate the available diagnostic tools. Vulvoscopy is one of the widely used methods, the diagnostic sensitivity and specificity of which varies significantly.Purpose of the work. Based on the analysis of publications to determine the diagnostic significance of vulvoscopy.Material and methods. The data of modern research and publications were used in the preparation of the work.Results. The authors of a number of publications warn against considering vulvoscopy as a variant of colposcopy. A high percentage of false positive results when performing tests with acetic acid may be due to a variety of reasons and is not highly specific for papillomavirus infection. The use of the test with toluidine blue is not recommended due to low sensitivity.Conclusions. A positive aspect of vulvoscopy is the ability to examine the vulva area with optical magnification, in a position convenient for examining the patient, which makes it possible to identify areas to be biopsied. The use of additional tests with acetic acid should be limited, and tests with toluidine blue and Lugol solution are not recommended due to low sensitivity.
Poly-3-hydroxybutyrate production from acetate by recombinant Pseudomonas stutzeri with blocked L-leucine catabolism and enhanced growth in acetate
Authors: Zhu Jieni , Liu Wei , Wang Mengjiao , Di Haiyan , Lü Chuanjuan , Xu Ping , Gao Chao , Ma Cuiqing 
Published: November 2023

Acetate is a low-cost feedstock for the production of different bio-chemicals. Electrochemical reduction of CO2 into acetate and subsequent acetate fermentation is a promising method for transforming CO2 into value-added chemicals. However, the significant inhibitory effect of acetate on microbial growth remains a barrier for acetate-based biorefinery. In this study, the deletion of genes involved in L-leucine degradation was found to be beneficial for the growth of Pseudomonas stutzeri A1501 in acetate. P. stutzeri (Δpst_3217), in which the hydroxymethylglutaryl-CoA lyase catalyzing β-hydroxy-β-methylglutaryl-CoA into acetyl-CoA and acetoacetate was deleted, grew faster than other mutants and exhibited increased tolerance to acetate. Then, the genes phbCAB from Ralstonia eutropha H16 for poly-3-hydroxybutyrate (PHB) biosynthesis were overexpressed in P. stutzeri (∆pst_3217) and the recombinant strain P. stutzeri (∆pst_3217-phbCAB) can accumulate 0.11 g L−1 PHB from commercial acetate. Importantly, P. stutzeri (∆pst_3217-phbCAB) can also use CO2-derived acetate to produce PHB and the accumulated PHB accounted for 5.42% (w/w) of dried cell weight of P. stutzeri (∆pst_3217-phbCAB).
Prediction of resting energy expenditure in Italian older adults with severe obesity
Authors: Danielewicz Ana Lúcia , Lazzer Stefano , Marra Alice , Abbruzzese Laura , D’Alleva Mattia , Martino Maria De , Isola Miriam , Avelar Núbia Carelli Pereira , Mendonça Vanessa Amaral , Lacerda Ana Cristina Rodrigues , Sartorio Alessandro 
Published: November 2023

BackgroundIn the last decade a large number of studies proposed and/or validated equations to estimate the Resting Energy Expenditure (REE) in adults and/or older adults, however, no equation currently available showed good accuracy for older adults with severe obesity. Thus, this study aimed to develop and validate new predictive equations for REE, based on data from the indirect calorimetry, in Italian older adults with severe obesity.MethodsA retrospective study was as conducted with 764 Caucasian older adults with severe obesity (age range: 60-74 years and BMI ≥ 35 kg/m/²). Four models were used to test the accuracy of anthropometry and body composition variables in multivariable prediction of REE. All models were derived by stepwise multiple regression analysis using a calibration group of 382 subjects [295 females and 87 males] and the equations were cross-validated in the remaining 382 subjects [295 females and 87 males] as validation group. The new prediction equations and the other published equations were tested using the Bland-Altman method. Prediction accuracy was defined as the percentage of subjects whose REE was predicted within ± 10% of measured REE.ResultsAll the equations analyzed predicted higher energy requirements for males than females, and most of them underestimated the energy requirement values of our sample. The highest accuracy values were observed in the new equations, with 62% in the anthropometric model and 63% in the body composition model.ConclusionAlthough the accuracy of our equations was slightly higher in comparison with the other taken into consideration, they cannot be considered completely satisfactory for predicting REE in Italians older adults with severe obesity. When predicting equations cannot guarantee precise or acceptable values of REE, the use of indirect calorimetry (if available) should be always recommended, especially in clinical practice.
Traditional Chinese exercises on pain and disability in middle-aged and elderly patients with lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials
Authors: Zhang Weiye , Wang Gewen , Xie Rong , Zhan Jiawen , Zhu Liguo , Wan Chunyou , Xie Hualong , Cai Chuhao , Du Yuxuan 
Published: November 2023

BackgroundTraditional Chinese exercises (TCEs) have played a significant role in treating various diseases. However, there is limited research assessing the efficacy of TCEs in treating Lumbar disc herniation (LDH). This study aimed to systematically evaluate the effects of four commonly used TCEs (Baduanjin, Yijinjing, Taichi, and Wuqinxi) on pain and disability in elderly patients with LDH.ObjectivesTo assess the quality of relevant randomized controlled trials (RCTs) to provide evidence support for the treatment of LDH.MethodsRCTs were identified through eight databases. Meta-analysis and trial sequence analysis (TSA) were conducted using RevMan 5.4, Stata 17.0, and TSA 0.9.ResultsA total of 22 RCTs, involving 1931 patients, were included in the analysis. TCEs exhibited a superior effectiveness in treating LDH compared to the control group. However, the TSA analysis suggested the possibility of false positives, indicating the need for more high-quality RCT evidence. Nevertheless, TCEs showed reliable results in significantly improving the VAS score and JOA score of LDH patients.ConclusionCurrent evidence indicates that the four TCEs have advantages in treating LDH in middle-aged and elderly individuals. However, considering the limitations of this study, we need to exercise caution in drawing conclusions, and further research is required to validate these findings.Systematic Review Registrationhttp://www.crd.york.ac.uk/PROSPERO, identifier [CRD42023431633].
Submuscular plating vs. elastic stable intramedullary nailing for diaphyseal femur fractures in children: a systematic review and meta-analysis
Authors: Li Donghui , Wang Xiangyue , Lu Jialing , Xue Mingfeng 
Published: November 2023

ObjectivesThis review evaluates the safety and efficacy of submuscular plating (SMP) vs. elastic stable intramedullary nailing (ESIN) in the treatment of pediatric femur shaft fracture.MethodStudies comparing the efficacy and safety of SMP and ESIN in pediatric shaft fracture were retrieved from five databases (PubMed, Embase, Cochrane, OVID, and Web of Science) from inception to March 2023 using a systematic literature search strategy. A total of 13 outcome measures, such as perioperative parameters, clinical outcomes, and radiographic results, were included in the meta-analysis.ResultsEight eligible studies involving 491 patients were included in the narrative synthesis. There were no significant differences in baseline characteristics between the two groups. Meta-analysis showed reduced radiation time (RT), soft tissue irritation and angular deformation in the SMP group than in the ESIN group. However, the SMP group had greater estimated blood loss (EBL) than the ESIN group. The duration of surgery, length of hospital stay (LOS), implant removal, complications requiring surgery, Flynn score, incidence of infection, fracture healing time, and limb length discrepancy (LLD) were similar between the two groups. Only one study reported higher incidences of fracture nonunion or delayed healing in the ESIN group.ConclusionSMP is an effective and safe intervention superior to ESIN in reducing soft tissue irritation, angular deformation and radiation time. Given the presence of potential bias and heterogeneity, surgeons should select the treatment that would provide the best outcomes for EBL, LOS, operation time, and bone nonunion or delayed healing based on their experience.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023404118, Identifier PROSPERO (CRD42021228512).
Identification of a Male-Produced Aggregation Sex Pheromone in Rosalia batesi, an Endemic Japanese Longhorn Beetle
Authors: Fukaya Midori , Kiriyama Satoshi , Yagami Saki , Iwata Ryûtarô , Yasui Hiroe , Tokoro Masahiko , Zou Yunfan , Millar Jocelyn G. 
Published: November 2023

The longhorned beetle Rosalia batesi Harold (Coleoptera; Cerambycidae) is endemic to Japan, where its range extends from Hokkaido to Kyushu. The colorful adults are well-known to entomologists and collectors worldwide. It is a hardwood-boring species with larvae that develop in dead broad-leaf trees. In laboratory bioassays, females were attracted to males, which suggested that males produce a sex pheromone. The congeneric species R. alpina is native to Europe, and another congener, R. funebris, is distributed in North America. The pheromone components produced by males of these species had been previously identified as two compounds from different biosynthetic pathways. In the present study, volatiles were collected from beetles of both sexes, and the analyses of the resulting extracts revealed a single male-specific compound, which was identified as 3,5-dimethyl-6-(1-methylbutyl)-pyran-2-one; this is the same compound as the pheromone of the European R. alpina. This alkylated pyrone structure is, so far, unique among known cerambycid pheromones. In field bioassays with traps baited with the racemic synthetic pheromone, significant numbers of both sexes of R. batesi were attracted in an approximately equal ratio, indicating that the compound is an aggregation-sex pheromone rather than a sex pheromone.
Effects of Epigenetic Modification and High Hydrostatic Pressure on Polyketide Synthase Genes and Secondary Metabolites of Alternaria alternata Derived from the Mariana Trench Sediments
Authors: Peng Qingqing , Li Yongqi , Fang Jiasong , Yu Xi 
Published: November 2023

The hadal biosphere is the most mysterious ecosystem on the planet, located in a unique and extreme environment on Earth. To adapt to extreme environmental conditions, hadal microorganisms evolve special strategies and metabolisms to survive and reproduce. However, the secondary metabolites of the hadal microorganisms are poorly understood. In this study, we focused on the isolation and characterization of hadal fungi, screening the potential strains with bioactive natural products. The isolates obtained were detected further for the polyketide synthase (PKS) genes. Two isolates of Alternaria alternata were picked up as the representatives, which had the potential to synthesize active natural products. The epigenetic modifiers were used for the two A. alternata isolates to stimulate functional gene expression in hadal fungi under laboratory conditions. The results showed that the chemical epigenetic modifier, 5-Azacytidine (5-Aza), affected the phenotype, PKS gene expression, production of secondary metabolites, and antimicrobial activity of the hadal fungus A. alternata. The influence of epigenetic modification on natural products was strongest when the concentration of 5-Aza was 50 μM. Furthermore, the modification of epigenetic agents on hadal fungi under high hydrostatic pressure (HHP) of 40 MPa displayed significant effects on PKS gene expression, and also activated the production of new compounds. Our study demonstrates the high biosynthetic potential of cultivable hadal fungi, but also provides evidence for the utility of chemical epigenetic modifiers on active natural products from hadal fungi, providing new ideas for the development and exploitation of microbial resources in extreme environments.
Improving access to general practice for and with people with severe and multiple disadvantage: a qualitative study
Authors: Potter Lucy C , Stone Tracey , Swede Julie , Connell Florrie , Cramer Helen , McGeown Helen , Carvalho Maria , Horwood Jeremy , Feder Gene , Farr Michelle , Gaps Bridging 
Published: November 2023

BackgroundPeople with severe and multiple disadvantage (SMD) who experience combinations of homelessness, substance misuse, violence, abuse, and poor mental health have high health needs and poor access to primary care.AimTo improve access to general practice for people with SMD by facilitating collaborative service improvement meetings between healthcare staff, people with lived experience of SMD, and those who support them; participants were then interviewed about this work.Design and settingThe Bridging Gaps group is a collaboration between healthcare staff, researchers, women with lived experience of SMD, and a charity that supports them in a UK city. A project was co-produced by the Bridging Gaps group to improve access to general practice for people with SMD, which was further developed with three inner-city general practices.MethodNine service improvement meetings were facilitated at three general practices, and six of these were formally observed. Nine practice staff and four women with lived experience of SMD were interviewed. Three women with lived experience of SMD and one staff member who supports them participated in a focus group. Data were analysed inductively and deductively using thematic analysis.ResultsBy providing time and funding opportunities to motivated general practice staff and involving participants with lived experience of SMD, service changes were made in an effort to improve access for people with SMD. These included prioritising patients on an inclusion patient list with more flexible access, providing continuity for patients via a care coordinator and micro-team of clinicians, and developing an information-sharing document. The process and outcomes improved connections within and between general practices, support organisations, and people with SMD.ConclusionThe co-designed strategies described in this study could be adapted locally and evaluated in other areas. Investing in this focused way of working may improve accessibility to health care, health equity, and staff wellbeing.