bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multisource data‐driven combined forecasting model based on internet search keyword screening method for interval soybean futures price
Authors: Luo Rui , Liu Jinpei , Wang Piao , Tao Zhifu , Chen Huayou 
Published: September 2023

AbstractAccurate soybean futures price prediction is critical to related agricultural production, warehousing, and trading. Interval forecasting can avoid the loss of fluctuation information and evaluate the uncertainty of futures prices. However, most previous studies only consider the single‐type auxiliary variable, which will cause the deficiency of valued information. Moreover, the research concentrating on internet search index ignores the search habits of investors, resulting in subjectivity in keyword selection. Therefore, a novel multisource data‐driven combined forecasting model is proposed that consists of four parts: unstructured data processing, interval multi‐scale decomposition, interval combination forecasting, and model evaluation. First, sentiment analysis technology is used to convert news text into sentiment scores. The internet search keyword screening method based on latent Dirichlet allocation is then constructed to achieve the quantification of investor attention. Second, a decomposition method is applied to decompose the original interval‐valued series into finite more stationary components. Third, interval prediction results are obtained by machine learning‐based multiple predictors. Finally, the model evaluation module comprising error evaluation indicators and comparison experiments is presented to verify the effectiveness. The experimental results show that the proposed model has higher prediction accuracy, which indicates that multisource data and designed keyword screening methods can enhance the forecasting performance of the model.
Tislelizumab augment the efficacy of CD19/22 dual‐targeted chimeric antigen receptor T cell in advanced stage relapsed or refractory B‐cell non‐Hodgkin lymphoma
Authors: Zhang Ying , Geng Hongzhi , Zeng Liangyu , Li Jiaqi , Yang Qin , Jia Sixun , Zong Xiangping , Cai Wenzhi , Liu Shuangzhu , Lu Yutong , Yu Lei , Li Caixia , Wu Depei 
Published: September 2023

AbstractDual‐targeted chimeric antigen receptor T (CAR‐T) cell is an important strategy to improve the efficacy of CD19 CAR‐T cell against refractory or relapsed B cell non‐Hodgkin lymphoma (R/R B‐NHL). However, durable responses are not achieved in most patients, in part owing CAR‐T cell exhaustion caused by PD‐1/PD‐L1 pathway. We conducted a prospective, single‐arm study of dual‐targeted CD19/22 CAR‐T cell combined with anti‐PD‐1 antibody, tislelizumab, in R/R B‐NHL (NCT04539444). Tislelizumab was administrated on +1 day after patients received infusion of CD19/22 CAR‐T cell. Responses, survival and safety were evaluated. From 1 August 2020 to 30 March 2023, 16 patients were enrolled. The median follow‐up time is 16.0 (range: 5.0–32.0 months) months. Overall response was achieved in 14 of 16 (87.5%) patients, and the complete response (CR) was achieved in 11 of 16 (68.8%) patients. The 1‐year progression‐free survival and overall survival rates were 68.8% and 81.3%, respectively. Of the 14 patients responded, 9 patients maintained their response until the end of follow‐up. Among the 15 out of 16 (93.8%) patients who had extranodal involvement, 14 (93.3%) patients achieved overall response rate with 11 (73.3%) patients achieving CR. Eight (50%) patients experienced cytokine release syndrome. No neurologic adverse events were reported. Gene Ontology‐Biological Process enrichment analysis showed that immune response‐related signaling pathways were enriched in CR patients. Our results suggest that CD19/22 CAR‐T cell combined with tislelizumab elicit a safe and durable response in R/R B‐NHL and may improve the prognosis of those patients.
Viscoelastic effects on the oscillatory flow in a fluid‐saturated porous layer
Authors: Raghunatha K. R. , Inc Mustafa , Vinod Y. 
Published: September 2023

AbstractThe oscillating flow of the viscoelastic fluid‐saturated porous layer has been useful in many areas, including the petroleum, chemical, and bioengineering industries. It is studied using the modified Darcy‐Oldroyd‐B model in this article. The exact solution is obtained utilizing a simpler and more reasonable method. According to this velocity solution, the time‐velocity profile of one kind of viscoelastic fluid is analyzed. From the analysis, it was found that the flow behaves like the Newton fluid when the oscillating frequency is low, and the flow reversal occurs when the oscillating frequency is high. Further, velocity, temperature, shear stress, and the rate of heat transfer are exponential solutions that are obtained and analyzed for different values of known physical parameters. Finally, we recognize that the relaxation and retardation parameters in this model act in the opposite manner.
Bank crisis management and resolution after SVB and Credit Suisse: Perspectives from India and the European Union
Authors: Shikha Neeti , Kapsis Ilias 
Published: September 2023

AbstractThe March 2023 bank failures of Silicon Valley Bank, Signature, and Credit Suisse, which caused turmoil in financial markets and led to regulatory and central bank intervention, revived the debate about the effectiveness of the bank crisis management, resolution, and deposit insurance legal framework established after the Global Financial Crisis. Although the March 2023 events did not escalate into a full‐blown financial crisis, they drew attention to certain areas of the current framework, where improvements may be needed. These areas include the need for financial regulation and supervision to focus more on small‐ and medium‐sized banks as potential sources of systemic market events; to review the adequacy of the current deposit insurance regime and the treatment of uninsured deposits; and to provide more clarity about the order of creditor claims in case of bank resolution/insolvency. This article reviews the events of March 2023 and the key lessons from these events and discusses how these lessons could shape the frameworks for bank crisis management and resolution in India and the European Union. The two jurisdictions are in the process of updating their laws in this area, and the March 2023 events could influence the relevant decisions.
Maternal and perinatal outcomes in women aged 42 years or older
Authors: Landry Maeva , Allouche Mickael , Vayssière Christophe , Guerby Paul , Groussolles Marion 
Published: September 2023

AbstractObjectiveTo describe maternal and fetal outcomes of pregnancies after 42 years and to compare maternal and fetal morbidities according to the conception mode; comparing pregnancies obtained spontaneously and those resulting from assisted reproductive technology (ART).MethodsThis retrospective cohort study was conducted in a level 3 maternity hospital. This study covered all women, aged 42 years or older, who gave birth between January 1, 2014 and December 31, 2019. Univariate and multivariate analyses with logistic regression models were used to compare maternal and perinatal outcomes depending on conception mode: spontaneous or using ART.ResultsA sample of 532 women, including 335 spontaneous pregnancies (63%) and 147 pregnancies after ART (27.6%) were studied. Conception mode was missing for 50 (9.4%). We found increased rates not only of maternal complications such as maternal overweight and obesity, pre‐eclampsia, and gestational diabetes, but also of interventions such as hospitalization during pregnancy, cesarean section, postpartum hemorrhage, and perinatal outcome like preterm birth. There were also more maternal and perinatal negative outcomes among the ART group. After multivariate analysis, pre‐eclampsia was predominant in the ART group (odds ratio 0.25, 95% confidence interval 0.07–0.85, P = 0.02).ConclusionWhile maternal and fetal risks increase for late pregnancies, there also appears to be a difference depending on the conception mode, with pregnancies resulting from ART having more pregnancy‐related complications than those obtained spontaneously.
Expectant management of tubal pregnancies with human chorionic gonadotropin up to 2000 mIU/mL
Authors: Kugelman Nir , Cohen Bracha , Yossef Fayrooz , Margieh Nadine , Regev Noam , Shani Uria , Bart Yossi 
Published: September 2023

AbstractObjectiveTo describe outcomes of expectant management (EM) versus methotrexate (MTX) treatment in tubal pregnancies with pretreatment human chorionic gonadotropin (hCG) less than 2000 mIU/mL.MethodsThis retrospective cohort from two tertiary hospitals included women with confirmed tubal pregnancies and pretreatment hCG <2000 mIU/mL. Exclusion criteria were unrecorded pregnancy site, unconfirmed diagnosis, and surgical treatment upon diagnosis. The primary outcome was eventual rate of surgical treatment.ResultsBetween December 2009 and June 2021, 545 of 2114 (25.8%) women diagnosed with a tubal pregnancy met our inclusion criteria. We compared women who underwent EM (N = 201) with women who received MTX (N = 344). All women in the EM group had a declining trend of hCG. The MTX group had higher pretreatment hCG and higher rates of yolk sac or embryo presence on ultrasound. Eventual surgical treatment rate was higher in the MTX group compared with the EM group (39 [11.3%] vs. 9 [4.5%], P = 0.006), with no difference in the treatment failure rate or tubal rupture rate. In a subgroup analysis of women with pretreatment hCG between 1000 and 2000 mIU/mL, eventual surgical treatment, treatment failure, and tubal rupture rates did not differ between groups. Logistic regression analysis revealed that eventual surgical treatment was independently associated with hCG levels less than 1000 mIU/mL (adjusted odds ratio [aOR] 0.28, 95% confidence interval [CI] 0.14–0.56) and endometriosis (aOR 9.20, 95% CI 3.55–23.81).ConclusionExpectant management of tubal pregnancies with pretreatment hCG levels less than 2000 mIU/mL and even between 1000 and 2000 mIU/mL and with a declining trend of hCG demonstrated lower or comparable rates of eventual surgical treatment, when compared with MTX treatment.
Per‐ and polyfluoroalkyl substances in water treatment residuals: Occurrence and desorption
Authors: Gravesen Caleb R. , Lee Linda S. , Alukkal Caroline R. , Openiyi Elijah O. , Judy Jonathan D. 
Published: September 2023

AbstractPer‐ and polyfluoroalkyl substances (PFAS) in surface and ground waters supplying municipal drinking water are a growing concern. However, PFAS concentrations in water treatment residuals (WTRs)—a solid by‐product of water treatment—have yet to be explored. In a first of its kind assessment, we examine PFAS occurrence in seven calcium (Ca)‐, iron‐, and aluminum‐based drinking water treatment residuals (DWTRs) and one wastewater effluent treatment residual (WWETR) produced using aluminum chlorohydrate (ACH). Only perfluoroalkyl acids (PFAAs) were detected, with total PFAA concentrations in the seven DWTRs produced from naturally recharged water sources ranging from 0 to ∼3.3 μg kg−1; no PFAS were detected in either of the Ca‐DWTRs. The ACH‐WWETR contained the highest number and concentration of PFAAs (34 μg kg−1). Desorption of resident PFAAs from the WTRs was negligible for the carboxylates (PFCAs). Some desorption of the sulfonates (PFSAs) was detected, particularly for PFOS which had the highest concentration among all resident PFAAs. The ACH‐WWETR was further evaluated for its potential to attenuate additional PFAAs (3500 μg mL−1 total PFAAs) in a biosolid‐derived porewater matrix. Sorption was highest for long‐chain PFAAs and subsequent desorption of the adsorbed PFAAs ranged from 0% to no more than 26%, with the WWETR mass added strongly affecting both PFSA and PFCA sorption/desorption. These findings suggest that WTRs, if introduced into the environment, are unlikely to be a major source of PFAS. Also, the use of particular WTRs as amendments may provide a beneficial reduction in PFAS mobility.
Whole Muscle and Single Motor Unit Twitch Profiles in a Healthy Adult Cohort Assessed With Phase Contrast Motor Unit MRI (PC‐MUMRI)
Authors: Birkbeck Matthew G. , Heskamp Linda , Schofield Ian S. , Hall Julie , Sayer Avan A. , Whittaker Roger G. , Blamire Andrew M. 
Published: September 2023

BackgroundMotor units (MUs) control the contraction of muscles and degenerate with age. It is therefore of interest to measure whole muscle and MU twitch profiles in aging skeletal muscle.PurposeApply phase contrast MU MRI (PC‐MUMRI) in a cohort of healthy adults to measure whole anterior compartment, individual muscles, and single MU twitch profiles in the calf. Assess the effect of age and sex on contraction and relaxation times.Study TypeProspective cross‐sectional study.SubjectsSixty‐one healthy participants (N = 32 male; age 55 ± 16 years [range: 26–82]).Field Strength/Sequences3 T, velocity encoded gradient echo and single shot spin echo pulsed gradient spin echo, echo‐planar imaging.AssessmentAnterior shin compartment (N = 47), individual muscle (tibialis anterior, extensor digitorum longus, peroneus longus; N = 47) and single MU (N = 34) twitch profiles were extracted from the data to calculate contraction and relaxation times.Statistical TestsMultivariable linear regression to investigate relationships between age, sex and contraction and relaxation times of the whole anterior compartment. Pearson correlation to investigate relationships between age and contraction and relaxation times of individual muscles and single MUs. A P value <0.05 was considered statistically significant.ResultsAge and sex predicted significantly increased contraction and relaxation time for the anterior compartment. Females had significantly longer contraction times than males (females 86 ± 8 msec, males 80 ± 9 msec). Relaxation times were longer, not significant (females 204 ± 36 msec, males 188 ± 34 msec, P = 0.151). Contraction and relaxation times of single MUs showed no change with age (P = 0.462, P = 0.534, respectively).Date ConclusionOlder participants had significantly longer contraction and relaxation times of the whole anterior compartment compared to younger participants. Females had longer contraction and relaxation times than males, significant for contraction time.Evidence Level2Technical EfficacyStage 1
Comparative analysis of nonlinear behavioral models for GaN HEMTs based on machine learning techniques
Authors: Liu Bo , Cai Jialin 
Published: September 2023

AbstractA variety of novel behavioral modeling techniques have been reported to accurately capture the nonlinear characteristics of GaN devices. For the purpose of describing GaN HEMT large‐signal behavior, machine learning‐based approaches have been proposed. There is, however, a lack of comparison and analysis of their performance with different machine learning techniques in these studies. An examination of machine learning‐based large‐signal modeling techniques is presented in this article. To develop large‐signal models of GaN HEMT, a range of commonly used modeling techniques such as artificial neural networks (ANN), random sample consistency (RANSAC), support vector regression (SVR), Gaussian process regression (GPR), decision trees (DTs), and genetic algorithm‐assisted ANN (GA‐ANN) are described and employed. Afterwards, integrated modeling techniques such as Bootstrap aggregation (BA), random forests (RF), AdaBoost, and gradient tree boosting (GTB) are reviewed and tested for their capabilities in developing GaN HEMT LSM. The hyperparameters of each built model are modified using the random search optimization (RSO) method, and five‐fold cross‐validation is used during validation. In order to identify optimal algorithms for nonlinear behavioral modeling of GaN devices, the model prediction results are comprehensively analyzed.
Long‐term changes in the frequency of exceptionally cold and warm months and seasons at selected stations in Europe in the early instrumental period
Authors: Skrzyńska Magdalena , Twardosz Robert , Walanus Adam 
Published: September 2023

AbstractExtreme thermal conditions have been known for a long time as is evidenced by the oldest preserved historical accounts referring to weather. However, direct data, that is, air temperature measurements, which began in Europe in the 17th century, are the only reliable source of information. They provide insight into how climate evolved over the characteristic period of the climate timeline known as the Little Ice Age. This study focuses on extreme climatic phenomena, referred to here as exceptionally cold (EC) and exceptionally warm (EW) months and seasons that occurred in the early instrumental period (until 1830). The research is based on average monthly air temperature values (of different lengths) from five meteorological stations in Europe. The Central England Temperature series (CET) offers the longest series that spans 172 years whereas Padua has the shortest, 57 years. Consequently, the year 1659, which is the start date of the Central England Temperature series, marks the beginning of the study period for the research presented in this article. Thermally anomalous periods are identified based on the standard deviation of the average temperature from the corresponding long‐term average (1831–2020). The highlights of the study include the identification of the pronounced prevalence at all five stations of EC months and seasons when compared to EW months and seasons, especially in Western Europe (CET) during the Maunder Minimum. The study also finds a lack of synchronicity in the timing of the anomalous periods under investigation in the different parts of Europe.
Aspects of resilience for smart manufacturing systems
Authors: Fowler Daniel S. , Epiphaniou Gregory , Higgins Matthew D. , Maple Carsten 
Published: September 2023

AbstractAn external disruptor to a manufacturing process (e.g., a supply chain failure, or a cyber‐attack) can affect more than a factory's output; it can have wider societal concerns, raising the issue of industrial resilience at different levels. In this work, manufacturing resilience is revisited, reviewing the applicability of the resilience concept to the industrial domain, particularly the smart factories enabled by newer digital technologies. The meaning of resilience within manufacturing is shown to be composed of several factors that operate at three levels (macro, meso, and micro). The factors have been united from a variety of sources to unify the traits within manufacturing resilience. Furthermore, a summary of the advanced digital technologies that can aid (or detract) from resilience is discussed, along with some of their challenges around digital complexity, legacy equipment support, high‐performance wireless communications, and cybersecurity. Although it is seen that digital manufacturing systems can aid resilience within the industrial sector and contribute to wider societal goals, the biggest impact is likely to be at the lowest (micro) level. Opportunities exist to quantify resilience factors and their use within manufacturing systems support software, and how to influence the resilience requirements of the wider stakeholders.
Controlling the elution order of insulin and its analogs in sub‐/supercritical fluid chromatography using methanesulfonic acid and 18‐crown‐6 as mobile phase additives
Authors: Neumann Jonas , Schmidtsdorff Sebastian , Schmidt Alexander H. , Parr Maria K. 
Published: September 2023

The purity analysis of therapeutic peptides can often be challenging, demanding the application of more than a single analytical technique. Supercritical fluid chromatography nowadays is a promising alternative to reversed‐phase liquid chromatography, providing orthogonal and complementary information. This study investigated its applicability for the separation of human insulin, its analogs and degradation products. A previously published method development protocol for peptides up to 2000 Da was successfully applied to the higher molecular weight insulins (6 kDa). A single gradient method was optimized for all insulins using a Torus DEA column (100 × 3.0 mm, 1.7 μm), carbon dioxide and a modifier consisting of methanol/acetonitrile/water/methanesulfonic acid (65:35:2:0.1, v/v/v/v). Consecutively, the crown ether 18‐crown‐6, which is well known to complex charged lysine sidechains and other amino functionalities, was added to the modifier to evaluate its impact on selectivity. A decreased retention and a shift in the elution order for the insulins were observed. An inverse effect on retention was found when combined with a neutral stationary phase chemistry (Viridis BEH).
Immune Profiling of Secreted Factors from Human Vestibular Schwannoma Cells and Tumor‐associated Macrophages
Authors: Stankovic Konstantina M. , Batts Shelley , Welling D. Bradley , Vasilijic Sasa 
Published: September 2023

ObjectivesThis study compared the immune‐related secretory capacity of human vestibular schwannoma (VS) and tumor‐assisted macrophages (TAMs) with their normal counterparts (Schwann cells [SC] and peripheral blood monocyte‐derived macrophages [Mo‐MFs], respectively), and examined relationships with presurgical hearing and tumor size.MethodsVS tumors (n = 16), auditory nerve (n = 1), blood (n = 9), and great auricular nerves (n = 3) were used. SCs (S100B+) and TAMs (CD68+) were isolated from VS tissue for culture. The secreted levels of 65 immune‐related factors were measured and compared using unpaired t‐tests with Welch correction (schwannoma vs. SCs) or Mann–Whitney tests (TAMs and Mo‐MFs). Associations between factor concentration and word recognition (WR), pure‐tone average (PTA), and tumor size were evaluated with Spearman correlation.ResultsSecreted factors with significantly higher concentrations in schwannoma versus SC supernatants included IL‐2 and BAFF, whereas MMP‐1, IL‐6, FGF‐2, VEGF‐A, MIP‐3α, and GRO‐α concentrations were significantly higher in TAMs versus Mo‐MFs (all p < 0.05). Worse WR was significantly associated with higher secretion of fractalkine, eotaxin‐3, CD30, and IL‐16 by VS cells; IP‐10, eotaxin‐3, multiple interleukins, GM‐CSF, SCF, and CD30 by TAMs; and TNF‐α and MIP‐1α by Mo‐MFs (all p < 0.05). Worse PTA was significantly correlated with higher secretion of IL‐16 by VS cells (p < 0.05). Larger tumor size was significantly correlated with higher secretion of eotaxin by VS cells, and of IL‐7, IL‐21, and LIF by TAMs (all p = 0.017).ConclusionsDifferential secretion of immune‐related factors was observed in schwannoma versus normal SCs and in TAMs versus Mo‐MFs, some of which were correlated with worse hearing and larger VS tumors.Level of EvidenceN/A Laryngoscope, 134:S1–S14, 2024