bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress in Age Estimation Based on DNA Methylation
Authors: Huang Yihang , Qu Shengqiu , Xiao Yuanyuan , Jian Hui , Liang Weibo 
Published: December 2023

Abstract
In forensic practice, the age of suspects or victims is crucial information that aids in the resolution of cases. In recent years, age estimation based on DNA methylation has gained significant attention in forensic science. DNA methylation, an epigenetic marker, undergoes specific changes with age, making it a valuable tool for inferring the age of samples left at crime scenes. Therefore, the identification of age-related DNA methylation markers and the development of novel age estimation models are of great importance in forensic medicine. Numerous studies in the past decade have successfully established age estimation models based on DNA methylation, demonstrating excellent sensitivity and accuracy. To provide a comprehensive review, the authors of this paper conducted a systematic review of relevant articles published from 2012 to the present. We used keywords such as “forensic,” “DNA methylation,” and “age estimation” to retrieve pertinent articles from the Web of Science database. The review covers various aspects, including the sources of sample tissues used for age estimation, DNA methylation conversion methods, and different techniques for DNA methylation detection. In addition, the paper reviews the modeling methods for age estimation based on DNA methylation and factors that can influence DNA methylation. Overall, this review serves as a valuable reference for forensic genetics, offering insights into the latest advancements in age estimation using DNA methylation. As the field of forensic science continues to evolve, the integration of DNA methylation-based age estimation into practice is expected to enhance the accuracy and reliability of age determination in criminal investigations.
Pinpointing the Short-tandem Repeats Alleles for Ethnic Inferencing in Forensic Identification by K-medoids Approach
Authors: Syukriani Yoni Fuadah , Hidayat Yuyun 
Published: December 2023

Abstract

Background:
The role of DNA analysis for ethnicity inferencing is a topic that attracts much interest from researchers in forensic identification, especially for identifying unknown bodies and trace evidence. So far, the approaches considered effective for ethnic inferencing are autosomal single-nucleotide polymorphisms, Y-chromosome short-tandem repeats (STRs), and mitochondrial DNA haplotyping, which successfully demonstrates the association of specific nucleotides or patterns with population groups. Ethnic inferencing based on autosomal STRs is complex due to the nature of recombination in gamete formation.

Aim:
This study attempts to use clustering analysis to associate alleles and loci of autosomal STRs with population groups.

Materials and Methods:
We examined the allele frequency data from 19 STRs loci from the Malay Indonesian population (n = 470) to compare with other populations, namely, Chinese Indonesian (n = 133) and four reference populations (Malay Malaysian, Filipino, Chinese, and Caucasian). K-Medoids clustering analysis was carried out to pinpoint alleles and loci affecting the population clustering process.

Results:
The first stage of clustering results placed Malay Indonesians and four other Asian populations, namely, Chinese Indonesian, Malay Malaysian, Filipino, and Chinese, in Cluster 1, whereas the Caucasian group was in Cluster 2. It indicates that the CSF1PO, D5S818, and D8S1179 loci significantly distinguished the five Asian population groups from the Caucasian group, whereas D2S441, D8S1179, and D22S1045 were the three loci that significantly influenced the separation between Malay Indonesians and other groups.

Conclusions:
We conclude that K-medoids clustering analysis has the potential to play a role in ethnicity estimation by pinpointing specific STRs alleles.
Matematiksel Tabu (TabuMaT) Oyununun Tasarlanması, Uygulanması ve Kavram Bilgisine Etkisi
Authors: ERGENE Özkan , YILMAZ Aybüke , HÖBEK Ömer Faruk , GÖKPINAR Bekir , OLTULU Mehmet Kemal 
Published: December 2023

Eğitsel bir oyun türü olan Tabu oyunu kavram öğretimi ve kelime kullanımı konularında kullanılmaktadır. Alanyazın incelendiğinde, Tabu oyunun anlatım ve dil kullanımı becerilerini geliştirmesine, kavram yanılgılarının tespit edilmesine, kavramsal anlama sürecine yardımcı olduğu görülmektedir. Bu araştırmada beşinci ve altıncı sınıf seviyesine yönelik Matematiksel Tabu (TabuMaT) oyununun tasarlanması, kullanılması ve öğrencilerin matematiğe yönelik kavram bilgilerine etkisinin incelenmesi hedeflenmiştir. Nicel araştırma ile yürütülen araştırmada ön test-son test kontrol gruplu yarı deneysel desen kullanılmıştır. Araştırmanın çalışma grubu 94 öğrenciden oluşmaktadır. Araştırmanın verileri, araştırmacılar tarafından geliştirilen ve geçerlik ve güvenirlik çalışmaları yapılan TabuMaT kavram testleri ve TabuMaT Değerlendirme Formu yardımıyla toplanmıştır. TabuMaT kavram testlerinden elde edilen veriler normallik sayıltısını sağlamasının ardından bağımsız örneklem t-testi, ilişkili örneklem t-testi ve betimsel istatistikler kullanılarak analiz edilmiştir. Araştırma sonunda, öğretim uygulamaları öncesinde matematiksel kavram bilgileri bakımından benzer olan beşinci ve altıncı sınıf deney ve kontrol grubunun uygulama sonunda son test puan ortalamaları arasında deney grupları lehine istatistiksel olarak anlamlı bir farklılığın olduğu görülmüştür. Ayrıca deney grubu öğrencilerinin TabuMaT oyununu öğretici olduğuna
ve sonraki matematik derslerinde de kullanılmasını istediklerine yönelik görüş bildirmişlerdir. Araştırma sonuçlarına dayalı olarak, TabuMaT oyunun farklı sınıf seviyeleri için tasarlanması ve mobil uygulama olarak dijitalleştirilmesi önerilebilir.
Grammatical Error Made By Students in Speaking English
Authors: Zahid Hurain 
Published: December 2023

Purpose: In today's world English is by far the most important language than any other and more spoken than it ever has been. English speaking plays a vital role in every human's life as it means to express ideas thoughts and feelings. This study is aimed to reveal the types of grammatical error and the cause of errors made by students while speaking English. Communication in English as a second language with the right use of grammar is not an easy task because a learner has to deal with so many problems to overcome and improve grammar.
Methodology: So it is important to classify and describe the various grammatical error to build a standardized structure for students to use and to know the rules of grammar.
Findings: The student highest grammatical errors were omission, misinformation. The Interlingua factors were misinformation and overuse of prepositions and incorrect word order which were based on their first language L1 transfer. Lastly, the last cause was the monotonous learning environment that cause anxiety which lack student confidence and they commit error in speaking.
Unique contributor to theory, policy and practice: Therefore, the present study aimed to examine grammatical errors made by students in speaking A quantitative method paradigm was applied utilizing questionnaire as a tool to collect data. The participants of the research are the students of BS all department of a private university. This method uses to analyze the data through purposive sampling. The study reveals the grammatical error that student strategies to a great extent and will focus on speaking, grammar and vocabulary.
Findings from Clinical, Historical, and Educational Research Conducted at the HOHM Foundation Office of Research
Authors: Gray Alastair , Straiges Denise 
Published: December 2023

Background: This presentation provides an overview of the research work at HOHM Foundation and the most inspiring results from the last 5 years, highlighting important findings from our numerous published and ongoing research projects. Methods: HOHM Foundation officially launched its Office of Research (HOHM Research) in 2017 in keeping with the mission to enrich and support homeopathy, and an overarching aim to build infrastructure whereby rigorous outcomes-based research supports the deepening and expansion of the discipline of Homeopathy. Results: Recent peer-reviewed publications include five papers on the education of complementary and integrative medicine practitioners, as well as three observational case series of selected COVID-19 cases from the HHN Clinic. Additional papers based on the 5000+ dataset of acute cases from the Homeopathy Help Network (HHN) clinic are currently being prepared. From the Practitioner Generated Research Network (PGRN) – an organization promoting practice-based, patient-focused, practitioner-generated research that potentizes the profession of homeopathy and expands it into the larger scientific and integrative medical communities - a paper exploring attitudes to and uptake of repertory software in homeopathy clinical practice was published in Homeopathy in 2023. Current papers from the PGRN in the publication phase include an observational clinical case series using MYMOP 2017-20, and an observational clinical case series using MYCaW 2020-22 data, both collected from clients who attended the Academy of Homeopathy Education (AHE) chronic clinic. Other current research work focusses on artificial intelligence in Homeopathy, on the characteristics, demographics and perceptions of users of homeopathy in the US, the 2022 North American homeopathy education surveys, the 2023 North American workforce survey, and a clinical trial on Homeopathy in the management of Silicosis taking place in Brazil. Discussion: HOHM Research produces robust, relevant publications, and bring awareness of the effectiveness of homeopathy through real-world, outcomes-based research, focusing on clinical, historical, and educational research outputs.
Chihuahua: 40 años de alternancia y participación ciudadana.
Authors: Borunda Escobedo José Eduardo , Camargo González Ignacio , Márquez Regalado Socorro 
Published: December 2023

Las elecciones en México han tenido una gran cantidad de variantes, sin embargo, el estado de Chihuahua representa una tierra de alteridad, de diferenciación política, de alternancia política en el poder ejecutivo estatal, de desplazamiento de las fuerzas políticas tradicionales y nuevas alianzas políticas que han roto con el bipartidismo dominante que había prevalecido durante gran parte del México contemporáneo, principalmente después de las primeras derrotas para el partido hegemónico en la década de 1980.
El arribo al gobierno federal del partido MORENA en el 2018 marcó una gran ruptura del electorado con los partidos tradicionales en la entidad (PAN – PRI) e impulsaron el voto por un cambio político que permeó de lo nacional a lo local. El PRI, que había dominado el escenario político entre los primeros lugares fue prácticamente ubicado en un tercero y cuarto lugar en el año 2021.
La geografía electoral del estado pasó de un color monocromático y/o bicolor a un espectro geográfico de diversos colores con triunfos regionales que marcaron las grandes diferencias ideológicas, económicas, culturales y sociales de un comportamiento electoral que se ha transformado en el escenario local.
Las preguntas de investigación que se plantean en el presente documento son ¿Porqué de los once partidos políticos que estuvieron en la boleta electoral del 2021 sólo cuatro lograron mantener su registro a nivel estatal? ¿Qué hay en la micro-política que impacta el comportamiento electoral en el Estado de Chihuahua como laboratorio de lo sub-nacional? ¿Cuál ha sido el comportamiento electoral en la elección de gobernador? ¿Existe realmente un cambio en las alternancias en el poder ejecutivo en el estado de Chihuahua?
Archibald Marshall’s “Motley Mixture of Crying Contradictions”: Upsidonia as Utopian Farce
Authors: Sinnema Peter W. 
Published: December 2023

ABSTRACT
Karl Marx’s acerbic observation in the opening lines of The Eighteenth Brumaire that “all facts and personages of great importance in world history occur the first time as tragedy, the second as farce” may be profitably applied to a reconsideration of literary farce sui generis, a genre represented in this article by a long-neglected work of utopian fiction, Archibald Marshall’s Upsidonia (1915). Although Upsidonia’s current disregard is arguably undeserved, the article’s chief interest is not to reclaim the novel on aesthetic grounds but to illuminate the mechanics of what Marx would call its “serious buffoonery.” In its persistent reversal of capitalist principles and relations, Upsidonia naturally invites readers to revisit Marx, whose mordant gambit may serve as a key to Marshall’s own farcical plot and praxis, rooted in return and repetition, the essential maneuvers of farce itself.
Determination of Indicators in the Information System Development for Monitoring and Evaluating Nutritional Interventions for Stunting Children
Authors: Wiliyanarti Pipit , Wulandari Yuanita , Nasrullah Dede 
Published: December 2023

Stunting is a serious problem that requires sustainable management and commitment from the state and all levels of society. Stunting data needs to be collected properly to develop strategies to eliminate the incidence of stunting. the information system for monitoring and evaluating nutritional interventions for stunting children is an information system that can be used for accelerated programs to eliminate the incidence of stunting. This study's aim was to analyze factors related to the use of the information system for monitoring and evaluating nutritional interventions for stunting children. A cross-sectional correlational design was used in this study. The variables were knowledge, data management, infrastructure, and the information system for monitoring and evaluating nutritional interventions for stunting children. One hundred and five stunting cadres were selected using a random sampling technique. Data collection was performed using self-report questionnaires. The Logistic Regression test was used to analyze the data. This study found that data management (p-value: 0.009), knowledge (p-value (0.000), and infrastructure (p-value: 0.018) elements affect the utilization of the information system for monitoring and evaluating stunting child nutrition interventions. In sum, the continuity of the information system for monitoring and evaluating stunting child nutrition interventions is expected to eliminate the incidence of stunting. Information systems for monitoring and evaluating stunting child nutrition interventions can be used as evidence to recommend strategies to eliminate stunting incidence. Therefore, community participation and government commitment are needed.
A COMPREHENSIVE ANALYSIS OF MICROBIAL CONTAMINATION ON MEDICAL PROFESSIONALS ATTIRE AND DEVICES
Authors: SHAIKH M , ZAMEER S , DEVI D , AHMED Z , KHOSO FM , SHAIKH AP , AAMIR K , RAMZAN A 
Published: December 2023

This research aimed to evaluate the level of microbiological contamination on the hands, white coats, and cell phones of healthcare workers. The study was conducted as a cross-sectional study at the Pathology Department of Civil Hospital LUMHS Hyderabad between January 2021 and June 2021. A total of 130 participants were selected using convenience sampling and provided samples. Before sample collection, informed consent was obtained from all participants. Samples were randomly collected from the hands of healthcare professionals, white coats, and various cell phones. Data analysis was performed using SPSS 23.0. In our study, 86 (66.2%) were females and 44 (33.8%) were males. There were 46 (35.4%) cases age 20-30 years, 34 (26.2%) cases aged 31-40 years, 28 (21.5%) cases had age 41-50 years, and 22 (16.9%) cases had age >50 years. 62 (47.7%) samples were taken from lab coats, 43 (33.1%) from the hand of healthcare workers, and 25 (19.2%) from cell phones. The results of the lab coat contamination analysis revealed the following: Methicillin-Resistant Staphylococcus aureus MRSA (6%), Escherichia coli (8%), Pseudomonas (2%), Klebsiella (3%), and Staphylococcus aureus (65%). Healthcare workers who were observed had a majority of MRSA (35.4%), Staphylococcus aureus (33.1%), Staphylococcus epidermidis (26.2%), and Pseudomonas (5%) on their hands. The most common bacteria found on mobile phones were MRSA (40%), followed by Staphylococcus aureus (18%), Staphylococcus epidermidis (34%), and pseudomonas (8%). This study demonstrates that a significant portion of the clothing and personal items used by healthcare professionals were tainted with different microorganisms that can cause nosocomial infections.
Приверженность городу: пилотажная оценка и предварительные психометрические показатели опросника
Authors: Потапова Юлия , Маленова Арина , Маленов Александр 
Published: December 2023

Проблема определения и изучения отношения человека к месту проживания ставится и решается через оценку приверженности городу. Приверженность раскрывается с позиций организационной психологии: выделяются общие и специфические признаки города как определенного типа организации, описывается и уточняется феноменология, позволяющая соотносить понятия городской приверженности, идентификации, идентичности. Приверженность городу понимается как особая форма отношения человека к месту жительства и окружающим, включающая городскую идентичность, выступающая предиктором степени его вовлечения в общественную жизнь, потенциального и реального миграционного поведения. Приводятся методологические предпосылки разработки структуры приверженности городу с целью создания опросника для ее оценки. Описаны процедура и результаты поискового исследования (N = 202) по валидизации опросника: разработана структура и содержание шкал (факторная модель включает три шкалы: лояльность, вовлеченность, идентификация), произведена проверка внутренней согласованности, ретестовой надежности и конвергентной валидности. Последняя проверялась путем сопоставления результатов диагностики приверженности городу с оценкой идентичности с городом С.А. Литвиной, О.И. Муравьевой и шкалой миграционных установок личности С.А. Кузнецовой, И.Ю. Кузнецова, А.В. Фещенко. В результате получены значимые средние и сильные положительные корреляции шкал опросника приверженности городу со шкалами идентичности с ним и средние отрицательные – со шкалами миграционных установок личности. Указываются перспективы применения и ограничения разработанного инструмента, допуская проекцию оценки приверженности человека конкретному городу на другие места проживания после дополнительных исследований.
A IMPORTÂNCIA DA EDUCAÇÃO CONTINUADA NA ATENÇÃO PRIMÁRIA À SAÚDE: REVISÃO NARRATIVA DA LITERATURA
Authors: Fernandes Priscila Castro Cordeiro , Dos Santos Dione Francisca , De Almeida  Jocilane Lima , da Silva Kenya Costa Rodrigues , Amaral Shirley Silva , Oliveira Julia , Horácio Vanete Ramos , Junqueira Ana Claudia Reis Oliveira , Do Nascimento Cicera Maria Alencar , Faria Gerusa Tomaz 
Published: December 2023

Este estudo aborda a relevância da Educação Continuada na Atenção Primária à Saúde, com foco nas equipes multiprofissionais das unidades de Saúde da Família. A Educação Continuada é delineada como um processo contínuo ao longo da carreira profissional, fundamental para manter os profissionais atualizados diante das transformações em suas áreas, principalmente na Atenção Primária à Saúde. A pesquisa, conduzida por meio de uma abordagem qualitativa e narrativa, explora a evolução da Educação Continuada na Atenção Primária à Saúde, diferenciando-a da Educação Permanente. A análise destaca a necessidade de adaptação contínua das equipes diante das mudanças epidemiológicas, tecnológicas e sociais. Os resultados e discussões revelam a importância da Educação Continuada na Atenção Primária à Saúde, destacando seu papel específico em proporcionar atualizações pontuais em momentos determinados da carreira. A pesquisa ressalta a necessidade de equipes de gestão especializadas em educação continuada para monitorar e manter atualizados protocolos de atendimento e fluxogramas. Além disso, o estudo enfatiza o papel crucial da equipe multiprofissional na Educação Continuada, ressaltando a troca de saberes entre profissionais de diferentes disciplinas.
EVALUATION OF CONTINUOUS GLUCOSE MONITORING (isCGM) ON TYPE 2 DIABETES PATIENTS TREATED WITH BASAL – BOLUS INSULIN THERAPY
Authors: Nguyen Thuy Duong , Nguyen Quang Bay , Nguyễn Khoa Diệu Van 
Published: December 2023

SUMMARY
Objective: Evaluate effectiveness of continuous glucose monitoring (isCGM) on type 2 diabetes patients treated with basal – bolus insulin therapy. Method: Descriptive and interventional study on 29 type 2 diabetes patients treated with basal – bolus insulin therapy at Department of Endocrinology and Diabetes, Bachmai Hospital from 1/2023 to 7/2023. Results: Average age is 61.4 ± 17.4. The majority oral antidiabetic drug is Metformin combined with Anti DDP4 (37%), bolus insulin is Regular (73%), basal insulin is Glargine U100 (97%). Average HbA1c is 10,8 ± 2,8 %, average serum glucose on arrival is 17.2 ± 11.6 mmol/L. Time in range on 14th day 66,2 ± 16.9% higher than the 1st day 55.1 ± 29.0% (p=0.03). CGM can detect more hypoglycemia events than point-of-care capillary blood glucose (34.2% versus 17.2%). Adverse reaction rate is 3.4% only. Conclusion: Continuous glucose monitoring is not only useful in controlling blood glucose level but also in detecting more hypoglycemia events than point-of-care capillary blood glucose.
Evaluation of Conservative Breast Surgery After Neoadjuvant Chemotherapy in Early Breast Cancer
Authors: Mohammad Ahmed Abdelshafy Ibrahim , Attia Sameh Gabr , Mahmoud Mohammad Omar 
Published: December 2023

Background: The breast cancer is a frequent type of cancers. It is associated with high mortality related to cancer in women. The treatment options transferred from radical surgery to less invasive operations. This was attributed to surgical advance and available neoadjuvant chemotherapy.
Objective: This work aimed to evaluate the conservative breast surgery feasibility and outcome for early breast cancer received neoadjuvant chemotherapy (NACT) for downstaging.
Patients and Methods: Thirty women (30) with early breast cancer were included between November 2022 and May 2023. All women were assessed in systematic manner by history, clinical, laboratory and radiological investigations before chemotherapy, before and after surgery. A true cut biopsy was drawn to estimate the histopathological nature. All surgeries were performed one and half months after the last session of NACT. A regular postoperative follow up was carried out up to six months. Any complications were recorded. Effect of NACT on the tumor grading was the primary outcome, while cosmetic results and patient satisfaction were the secondary outcomes.
Results: Complications were in the form of wound infection, seroma and hematoma in 6.7%, 13.3% and 3.3% respectively. These were mild and treated conservatively. The excellent cosmetic result was achieved for 80.0% and excellent patient satisfaction was recorded for 60.0%. The effect of chemotherapy showed significant improvement of clinical and pathological post chemotherapy tumor size values when compared to clinical tumor size values before chemotherapy, the T1 grade (≤2cm) increased from 50% to 66.7%, while the T2 grade (> 2cm <5 cm) decreased from 50% to33.3%.
Conclusion: NACT was associated with excellent response regarding tumor size reduction, negativity of lymph nodes as well as pathological response of early breast cancer, before breast conservation surgery (BCS). The BCS after NACT could be considered as a safe option with acceptable aesthetic outcome.