bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of P‐selectin in radiation‐induced intestinal inflammatory damage
Authors: Mollà Meritxell , Gironella Meritxell , Salas Azucena , Miquel Rosa , Pérez‐del‐Pulgar Sofia , Conill Carles , Engel Pablo , Biete Albert , Piqué Josep M. , Panés Julián 
Published: October 2002

AbstractThe aims of our study were to characterize the dose‐ and time‐dependent changes in endothelial P‐selectin expression and the role of this adhesion molecule as a mediator of radiation‐induced inflammation. For that purpose, endothelial P‐selectin expression was measured by the radiolabeled antibody technique in control and irradiated mice at 2, 6, and 24 hr following abdominal irradiation with 4 or 10 Gy; leukocyte endothelial cell interactions were assessed using intravital microscopy in intestinal venules following irradiation at the aforementioned doses and times in C57BL/6 and P‐selectin‐deficient mice. In wild‐type mice, radiation induced a time‐ and dose‐dependent up‐regulation of P‐selectin and a significant increase in the flux of rolling leukocytes 2 hr after irradiation. Irradiation induced a significant increase in leukocyte adhesion that was dose‐dependent. Following irradiation, P‐selectin‐deficient mice did not show any increase in leukocyte rolling but did demonstrate a response in leukocyte adhesion similar to that of the wild‐type mice. Radiation‐induced dose‐dependent histological inflammatory damage that did not differ between P‐selectin‐deficient and wild‐type mice. We conclude that P‐selectin is up‐regulated following irradiation and is a key molecular determinant of leukocyte rolling but not leukocyte adhesion in this inflammatory condition. Therefore, isolated neutralization of this adhesion molecule is not an effective means for preventing radiation‐induced inflammation. © 2001 Wiley‐Liss, Inc.
Adjuvant radiotherapy following radical prostatectomy is more effective and less toxic than salvage radiotherapy for a rising prostate specific antigen
Authors: Anscher Mitchell S. 
Published: October 2002

AbstractDespite the trend toward earlier diagnosis of adenocarcinoma of the prostate, approximately 25% of men undergoing radical prostatectomy will have pathologic evidence of cancer extending outside of the prostate. These patients are at high risk for subsequent recurrence. Such relapses are almost always manifested initially as a rise in the Prostate Specific Antigen (PSA). Currently utilized PSA assays, however, will not detect a recurrence smaller than 107 to 108 cells, nor does PSA identify the site of recurrence. In contrast, the pathologic findings at the time of surgery can be used to reliably distinguish patients at risk for local recurrence from those more likely to fail distantly. Furthermore, adjuvant pelvic radiotherapy after prostatectomy, given to patients with an undetectable PSA who are at high risk for local recurrence, results in a higher disease free survival and fewer side effects than if radiotherapy is delayed until the PSA begins to rise. Thus, patients at high risk for local failure following radical prostatectomy, but at low risk for distant metastases (i.e., those with positive surgical margins and an undetectable PSA) should be offered immediate adjuvant radiotherapy. © 2001 Wiley‐Liss, Inc.
Radiation therapy (RT) after prostatectomy: The case for salvage therapy as opposed to adjuvant therapy
Authors: Schild Steven E. 
Published: October 2002

AbstractPatients with pathologic stage T3 or T4 prostate cancer who have undetectable PSA levels following radical retropubic prostatectomy (RRP) have a substantial risk of recurrence. Radiotherapy (RT) can be administered immediately following the RRP (immediate adjuvant RT) or may be postponed until the PSA level has risen to a level that is indicative of residual or recurrent prostate cancer (salvage RT). Immediate adjuvant RT can significantly reduce the risk of relapse, but does not appear to increase the rate of survival. Approximately two‐thirds of patients with rising PSA levels after RRP can be salvaged with RT alone. This result was achieved in patients treated with an adequate dose of radiation before the PSA rose to > 1.1 ng/ml. While no one can be certain which approach (adjuvant or salvage RT) is better, future studies should examine this issue. Whether immediate postoperative adjuvant RT is of value to patients is the subject of two randomized prospective studies. The benefit of adjuvant RT is a matter of controversy. Salvage RT treats only those patients with proven residual prostate cancer. The salvage RT approach has several advantages. This approach spares approximately 40% of patients who have had an RRP for T3 or T4 prostate cancer and eliminates the risks and costs associated with adjuvant RT. Additionally, it appears that the results of immediate adjuvant RT are similar to those achieved with early salvage RT. © 2001 Wiley‐Liss, Inc.
Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas
Authors: Ozaki Toshifumi , Schaefer Karl‐Ludwig , Wai Daniel , Buerger Horst , Flege Silke , Lindner Norbert , Kevric Matthias , Diallo Raihanatou , Bankfalvi Agnes , Brinkschmidt Christian , Juergens Heribert , Winkelmann Winfried , Dockhorn‐Dworniczak Barbara , Bielack Stefan S. , Poremba Christopher 
Published: October 2002

AbstractOsteosarcomas are the most frequent bone sarcomas. The molecular chromosomal aberrations in osteosarcomas were analyzed by comparative genomic hybridization (CGH). We studied 47 frozen tumors (41 primary samples, 6 relapses) in osteosarcoma patients registered in the Cooperative Osteosarcoma Study (COSS) protocol. Genomic imbalances were detected in 40 of 41 primary tumors and 6 of 6 relapsed tumors. Gains were more frequent than losses (ratio of 1.3:1). The median number of changes was 16 and 12 in primary and relapsed osteosarcomas, respectively. The median number of aberrations in primary high‐grade osteosarcomas (17.0) was significantly higher than in low‐ or intermediate‐grade osteosarcoma subtypes (3.0) (p = 0.038). The most frequent gains included 8q, 1p21‐p31 and 1q21‐q24, and the most frequent losses were 10q, 5q and 13q. High‐level gains were observed on 8q23‐q24, 17p13 and 1q21‐q24. A gain of 19p (p < 0.001) or loss of 9p (p = 0.027) was more frequent in poor responders than in good responders. Univariate analysis revealed that patients with primary metastases (p = 0.002), poor histologic responses (p = 0.005), high‐level gains of 19p (p = 0.012) or losses of 13q14 (p = 0.042) had significantly lower event‐free survival (EFS), whereas patients with a loss of 5q (p = 0.007) or a loss of 10q21‐22 (p = 0.017) had significantly higher EFS than patients without these aberrations. Multivariate analysis demonstrated that primary metastasis, loss of 13q14 and loss of 5q were independent prognostic factors. The findings of our study seem to be useful for evaluating the prognosis of patients and may finally lead to treatment strategies based on genetic background of osteosarcoma. © 2002 Wiley‐Liss, Inc.
Prostate stem cell antigen: Identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients
Authors: Kiessling Andrea , Schmitz Marc , Stevanovic Stefan , Weigle Bernd , Hölig Kristina , Füssel Monika , Füssel Susanne , Meye Axel , Wirth Manfred P. , Rieber Ernst Peter 
Published: October 2002

AbstractIdentification of TAAs recognized by CD8+ CTLs paved the way for new concepts in cancer therapy. In view of the heterogeneity of tumors and their diverse escape mechanisms, CTL‐based cancer therapy largely depends on an appropriate number of TAAs. In prostate cancer, the number of antigens defined as suitable targets of CTLs remains rather limited. PSCA is widely distributed in prostate cancer. In this report, we define immunogenic peptides of PSCA which are recognized by circulating CD8+ T cells from prostate cancer patients and able to activate CTLs in vitro. Screening the amino acid sequence of PSCA for peptides containing a binding motif for HLA‐A*0201 resulted in 8 candidate peptides. Specificity and affinity of peptide binding were verified in a competition assay. Frequencies of CD8+ T lymphocytes reactive against selected epitopes were determined in the blood of prostate cancer patients using the ELISPOT assay. Increased frequencies were revealed for CD8+ T cells recognizing the peptides ALQPGTALL and AILALLPAL. CTLs from prostate cancer patients were raised against these 2 peptides in vitro when presented by autologous DCs. They specifically recognized peptide‐pulsed T2 target cells and prostate cancer cells that were HLA‐A*0201‐ and PSCA‐positive, indicating that these peptides were naturally generated by tumor cells. These data suggest that PSCA is a promising target for the immunotherapy of prostate cancer. © 2002 Wiley‐Liss, Inc.
Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis
Authors: Martini Maurizio , Ciccarone Mariavita , Garganese Giorgia , Maggiore Claudia , Evangelista Antonella , Rahimi Siavash , Zannoni Gianfranco , Vittori Giorgio , Larocca Luigi Maria 
Published: October 2002

AbstractEndometriosis is a common gynecologic disease, which generally follows a benign course. Notwithstanding, several clinical and histologic studies as well as molecular data show that endometriosis could be a precursor of sporadic endometrioid and clear cell carcinomas at extrauterine loci. Several reports have implicated alterations of the hMLH1 and p16ink4a
(p16) genes, in particular hypermethylation of the promoter region, and of the PTEN gene, principally genetic mutations, in endometrial and ovarian cancers and have indicated that these alterations are already present in precancer conditions. In this report, we analyzed the methylation status of hMLH1 and p16 and the protein expression of PTEN and hMLH1 in 46 cases of endometriosis stages III and IV to better define the possible involvement of these genes in the malignant transformation of endometriosis. We found abnormal methylation of hMLH1 in 4 of the 46 cases (8.6%). In addition, these cases had no detectable hMLH1 protein expression. Regarding patients with hMLH1 alterations, 2 were classified as stage IV and 2 showed coexistent endometriosis and carcinoma. Only 1 case of endometriosis (2.17%), classified as atypical, showed abnormal methylation of p16. Reduced PTEN protein expression was detected in 7 of 46 cases (15.21%): 5 were clinically classified as stage IV, and the other 2 presented both cancer and hypermethylated hMLH1. Our preliminary study suggests that reduced expression of both hMLH1 and PTEN may be involved in the malignant evolution of endometriosis and should be used as markers of neoplastic transformation in aggressive endometriosis with elevated tumor markers. © 2002 Wiley‐Liss, Inc.
Alcohol drinking outside meals and cancers of the upper aero‐digestive tract
Authors: Dal Maso Luigino , La Vecchia Carlo , Polesel Jerry , Talamini Renato , Levi Fabio , Conti Ettore , Zambon Paola , Negri Eva , Franceschi Silvia 
Published: October 2002

AbstractIn our integrated series of case‐control studies conducted in Italy and Switzerland (324 oral, 397 pharyngeal, 271 oesophageal, 506 laryngeal cancers and 3,263 controls), individuals who also drank alcoholic beverages outside meals showed an increased risk compared to those who drank at meals only. At any alcohol intake level, subjects also drinking between meals showed a more elevated risk of developing an upper aero‐digestive tract cancer than subjects drinking only at meals. After adjustment for potential covariates, and, after allowance for the number of daily drinks to adjust for different alcohol‐intake levels, the odds ratios for subjects reporting drinking outside meals were 1.5 (95% confidence interval [CI]: 1.0–2.2) for oral, 1.8 (95% CI: 1.3–2.5) for pharyngeal, 1.7 (95% CI: 1.2–2.5) for oesophageal and 1.2 (95% CI: 0.9–1.7) for laryngeal cancers. Our findings show that drinking pattern with respect to food consumption may influence alcohol carcinogenesis in the upper digestive and respiratory tract. An “alcohol washing effect” by chewing and swallowing is suggested. © 2002 Wiley‐Liss, Inc.
Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells
Authors: Sutter Andreas P. , Maaser Kerstin , Höpfner Michael , Barthel Bettina , Grabowski Patricia , Faiss Siegbert , Carayon Pierre , Zeitz Martin , Scherübl Hans 
Published: October 2002

AbstractEsophageal cancer is the most markedly increasing tumor entity in Western countries. Due to very poor 5‐year‐survival, new therapeutic approaches are mandatory. Peripheral benzodiazepine receptors (PBR) have been implicated in growth control of various tumor models, but they have not been studied yet in esophageal cancer. We used esophageal cancer cell lines and primary cell cultures of human esophageal cancers and evaluated (i) expression and localization of PBR; (ii) PBR‐ligand‐induced inhibition of cell growth; (iii) induction of apoptosis; and (iv) alterations in cell cycle. Expression of PBR was detected both in cell lines and in primary cell cultures of human esophageal cancers. PBR was localized in the mitochondria. The PBR‐specific ligands FGIN‐1‐27 and PK 11195, but not the centrally acting benzodiazepine clonazepam or the indolacetamide FGIN‐1‐52, neither of which displaying any affinity to the PBR, inhibited cell proliferation. FGIN‐1‐27 and PK 11195, but not clonazepam, potently induced apoptosis. FGIN‐1‐27 was shown to sequentially decrease the mitochondrial membrane potential, then to activate caspase‐3 and finally to cause DNA fragmentation. In addition, PBR‐specific ligands induced cell cycle arrest in the G1/G0 phase. Our data qualify PBR‐specific ligands as innovative proapoptotic and antiproliferative substances. They might prove suitable for the treatment of esophageal cancer. © 2002 Wiley‐Liss, Inc.
Cancer incidence patterns among Vietnamese in the United States and Ha Noi, Vietnam
Authors: Le Gem M. , Gomez Scarlett L. , Clarke Christina A. , Glaser Sally L. , West Dee W. 
Published: October 2002

AbstractNearly 600,000 persons have immigrated to the United States from Vietnam since the end of the Vietnam War. Despite the rapid growth of the U.S. Vietnamese population, little is known about cancer incidence in this migrant group. Using population‐based data from the Surveillance, Epidemiology and End Results program, California Cancer Registry and International Agency for Research on Cancer, we compared cancer incidence rates for Vietnamese in the United States (1988–1992) to rates for residents of Ha Noi, Vietnam (1991–1993); non‐Hispanic whites were included to serve as the U.S. reference rates. Lung and breast cancers were the most common among Vietnamese males and females, respectively, regardless of geographic region. Rates of cancers more common to U.S. whites, such as breast, prostate and colon cancers, were elevated for U.S. Vietnamese compared to residents in Ha Noi but still lower than rates for U.S. whites. Rates of cancers more common to Asian countries, such as stomach, liver, lung and cervical cancers, were likewise elevated for U.S. Vietnamese compared to residents of Ha Noi and exceeded corresponding rates for whites. Incidence patterns for stomach, liver, lung and cervical cancers may reflect increased risk of exposures in this migrant population and should be further explored to uncover the relative contributions of environmental and genetic factors to cancer etiology. © 2002 Wiley‐Liss, Inc.
Association of genotypes of carcinogen‐activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N‐acetyltransferase NAT2, with urothelial cancer in a Japanese population
Authors: Ozawa Shogo , Katoh Takahiko , Inatomi Hisato , Imai Hirohisa , Kuroda Yoshiki , Ichiba Masayoshi , Ohno Yasuo 
Published: October 2002

AbstractCarcinogenic aromatic amines such as 4‐aminobiphenyl, which is contained in tobacco smoke, are one of the causal factors of urothelial epithelial cancers. 4‐Aminobiphenyl has been shown to be bioactivated through N‐hydroxylation by hepatic cytochrome (CYP) 1A2 and subsequently through O‐sulfation and O‐acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N‐acetyltransferase, NAT2, respectively. In a case‐control study for urothelial epithelial cancers, low activity alleles of NAT2 are overall high‐risk alleles (OR 2.11; 95% CI 1.08–4.26). Wild‐type ST1A3*1 (213Arg) alleles were slightly overrepresented in nonsmoking urothelial cancer patients (82.6% vs. 69.7%) and in smoking cancer patients (76.7% and 74.3%) compared to a variant ST1A3*2 (213His) allele. In combination of ST1A3 and NAT2 genotypes for analyses of urothelial cancer risk, the highest OR of 2.45 (95% CI 1.04–5.98) was obtained with ST1A3*1 and NAT2 slow genotype among the 4 combinations. Recombinant ST1A3*1 enzyme showed a tendency of catalyzing higher in vitro 3′‐phosphoadenosine 5′‐phosphosulfate‐dependent DNA adduct formation than ST1A3*2 (2.84 ± 0.49 and 2.22 ± 0.11 adducts/108 nucleotides). Combined analyses of different alleles of carcinogenic aromatic amine‐activating phase II enzymes were applied to urothelial cancer risk for the first time and showed the highest risk combination of ST1A3 and NAT2 alleles. © 2002 Wiley‐Liss, Inc.
How to profit from new trends in treasury management
Authors: Danko Dori , Godwin Joseph H. , Goldberg Stephen R. 
Published: October 2002

AbstractWhat are the latest trends in treasury management? The authors take a comprehensive look at what's
happening today, and how you can profit from it. By staying ahead of the curve, you can manage successfully in
any business environment. © 2002 Wiley Periodicals, Inc.
Ten working capital blunders to avoid
Authors: Payne Stephen M. 
Published: October 2002

AbstractWith the economy in the doldrums, it's tough to access traditional sources of operating capital. So many
companies try to generate as much cash as they can internally. And one of the best ways to do that is to better
manage your working capital. But are you falling prey to these common working capital blunders?
© 2002 Wiley Periodicals, Inc.
How are worldwide accounting standards changing?
Authors: Reinstein Alan , Weirich Thomas R. 
Published: October 2002

AbstractThere's been a difference between U.S., GAAP, and accounting standards elsewhere in the world. But the
IASB has proposed a major revision of its standards. How would things change? And what is the role of the
IASB in “harmonizing” global standards? © 2002 Wiley Periodicals, Inc.
To ensure ethical reporting and better corporate governance, attack the causes
Authors: Player Steve 
Published: October 2002

AbstractTightening accounting rules and even jailing executives who abuse them will not completely solve all the
problems of corporate governance and executive misbehavior we've witnessed over the past few years. The author
argues that investors and regulators would be better served by finding out why executives—and managers at all
levels—engage in such practices and suggests how to attack the disease itself, not just the symptoms.
© 2002 Wiley Periodicals, Inc.
Building public trust and optimizing finance
Authors: Goldberg Stephen R. , Godwin Joseph H. 
Published: October 2002

AbstractDiPiazza, Samuel A. Jr., and Robert G. Eccles. 2002. Building Public Trust, the Future of Corporate
Reporting (New York: John Wiley & Sons).Donegan, Michael C. 2002. Growth and Profitability: Optimizing the Finance Function for Small and
Emerging Businesses (New York: John Wiley & Sons).
A LINC demonstrator based on switchable phase shifters
Authors: Tan Jee Seet , Gardner Peter 
Published: October 2002

AbstractThis paper presents a 2 GHz LINC transmitter demonstrator that generates a 16‐QAM (Quadrature Amplitude Modulation) signal using switchable phase shifters fabricated on a low cost substrate (FR4, 1.6 mm, εr = 4.6). The number of switch elements required has been reduced from 16 per branch to 6 per branch by a careful analysis of the complete set of combinations required. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 262–264, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10577
NF‐FF transformation with cylindrical scanning from a minimum number of data
Authors: D'Agostino F. , Ferrara F. , Gennarelli C. , Riccio G. , Savarese C. 
Published: October 2002

AbstractIn this paper, an efficient sampling representation for reconstructing the voltage measured by a probe over a cylinder in the antenna NF region from a minimum number of data is proposed, and properly exploited to develop two probe compensated NF–FF transformation techniques. They are based on the theoretical results relevant to the nonredundant representation of electro‐magnetic fields. Numerical examples assess the accuracy and stability of the techniques. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 264–270, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10578
Experimental studies of X‐band leaky‐wave antenna performances
Authors: Ivanchenko I. , Ivanchenko D. , Korolyov A. , Popenko N. 
Published: October 2002

AbstractIn this paper, we present the results of measuring the near‐field and radiation patterns of a novel leaky‐wave antenna. Although the first higher order mode in the antenna can be successfully excited in a wide frequency band, the leaky‐wave radiation is limited to a relatively narrow frequency band of about 1.8 GHz. Outside this band, the antenna radiates as a phased array of local oscillators and demonstrates a multi‐beam radiation pattern. Investigations of modified antenna design have revealed new opportunities to improve antenna characteristics by changing the width and location of the impedance transformer, as well as by inserting electrical dipoles at the fixed locations of standing waves formed along the radiating microstrip line. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 277–281, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10581
Apodized long‐period grating with low insertion loss
Authors: Yang Xiufeng , Guo Xin , Lu Chao , Hiang Cheng Tee 
Published: October 2002

AbstractThe characteristics of an apodized long‐period grating are studied experimentally and theoretically. It has no side‐lobes and almost zero insertion loss in the pass band. Changing the dc and maximum ac index along the z direction of LPG can conveniently control wavelength and the value of peak loss. Suitable spectral profile of gain‐flattening filter with low insertion loss is obtained by writing two or three consecutive apodized sub‐gratings in one fiber with the different UV power level in the second exposure. The experiment results are in good agreement with the simulation results. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 283–286, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10583
Printed dual‐band monopole antenna for 2.4/5.2 GHz WLAN access point
Authors: Tung Hao‐Chun , Fang Shyh‐Tirng , Wong Kin‐Lu 
Published: October 2002

AbstractA new design of the printed trident monopole antenna for applications in 2.4/5.2 GHz dual‐band wireless local area network (WLAN) access points is presented. The trident monopole antenna comprises a central arm for the 2.4 GHz band (2.4–2.484 GHz) operation and two side arms for the 5.2 GHz band (5.15–5.35 GHz) operation. The obtained impedance bandwidth (1.5:1 VSWR) for a constructed prototype covers the required bandwidths of the 2.4 and 5.2 GHz bands, and the maximum antenna gain reaches about 4.0 and 5.5 dBi across the 2.4 and 5.2 GHz bands, respectively. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 286–288, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10585