bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probiotic preparation SBT-Lacto and phytobiotic thyme extract as growth stimulants in calves
Authors: Shevchenko A. I. , Shevchenko S. A. , Zaborskikh E. Y. , Buguev E. G. 
Published: January 2024

In the conditions of a scientific and economic experiment in the mid-mountain zone of the Altai Republic, the effect on the growth performance of Simmental calves of the probiotic drug SBT-Lacto and the phytobiotic thyme extract, which were fed to the animals with milk in the first month of their life, was studied. Calves of the 1st experimental group received thyme extract from the 22nd to 42nd days of life, the 2nd group - SBT-Lacto from the 1st to 21st days, and the 3rd experimental group - SBT-Lacto from the 1st day. x to the 21st day and thyme extract from the 22nd to the 42nd day. It was found that the absolute increase in body weight in the 1st experimental group did not significantly exceed the control indicator by 5.20 %; in the 2nd experimental group, the excess was 12.49 % and was significant. The maximum effect was obtained in the 3rd experimental group. The absolute increase in body weight of animals in this group significantly exceeded the control indicator - by 16.92 %. Thus, sequential separate feeding of thyme extract and probiotics to calves had a more pronounced positive effect on their growth. The improvement in growth rates of calves in the experimental groups can be explained by the normalisation of the composition of the intestinal microflora under the influence of the probiotic drug SBT-Lacto and the activation of digestive processes by substances contained in the thyme extract. A synergistic effect was obtained with the combined sequential use of these factors.
The dependence of yield and its structure on pre-sowing treatment of spring triticale (<i>× triticosecale</i>) seeds in the Amur region
Authors: Muratov A. A. , Epifantsev V. V. , Tuaeva E. V. 
Published: January 2024

The research results (2014 - 2015) on triticale yield and its structure depending on the seed treatment are presented. The need for research is caused by increasing grain yields and gross yields in the region. This work aims to establish the dependence of yield and its structure on the pre-sowing treatment of triticale seeds by modern fungicides that are effective in extreme conditions. A two-factor field experiment was conducted on the experimental field of the Far Eastern State Agrarian University, Amur region. Options: Factor A - triticale varieties: 1. Ukro, St; 2. Yarilo; 3. Carmen. Factor B - treatment with preparations: 1. Control - water; 2. Maxim rate - 1.5 ml/l; 3. Inshur Perform - 0.4 l/ha; 4. Kinto Duo - 2 l/ha. Each variety of triticale corresponded to fourvariants of treatment with preparations. Regarding height, productive business and ear length of triticale, the differences between the preparations and the control were insignificant. The preparation of Kinto Duo increased the number of grains in the ear by 2.0 % compared with the control. Maxim and Inshur Perform by weight of 1000 grains resulted in a significant increase of 2.8 and 3.9 %, and Kinto Duo - 7.2 % compared to the control. Yield is strongly related to productive business, r = 0.798. The correlation between yield and stem length is medium r = 0.332. Between yield, ear length, number of grains in the ear, and weight of 1000 grains, the correlation dependence is weak r < 0.3. The preparation Inshur Perform increased the yield of triticale grain by 0.11 t/ha or 4.9 %, Maxim - by 0.30 t/ha or 13.4 %, and Kinto Duo - by 0.34 or 15.2 % relative to the control.
Living with Dysphagia: A Survey Exploring the Experiences of Adults Living with Neuromuscular Disease and their Caregivers in the United Kingdom
Authors: Allen Jodi , Stone-Ghariani Aoife , Quezada Gabriella , Banks Donna , Rose Frank , Knight William , Newman Jill , Newman William , Anderson Philip , Smith Christina 
Published: January 2024

Background: Dysphagia is common in adults living with neuromuscular disease (NMD). Increased life expectancy, secondary to improvements in standards of care, requires the recognition and treatment of dysphagia with an increased priority. Evidence to support the establishment of healthcare pathways is, however, lacking. The experiences of people living with NMD (pplwNMD) and their caregivers are valuable to guide targeted, value-based healthcare. Objective: To generate preliminary considerations for neuromuscular dysphagia care and future research in the United Kingdom, based on the experiences of those living with, or caring for, people with NMD. Methods: Two surveys (one for adults living with NMD and dysphagia, and a second for caregivers) were co-designed with an advisory group of people living with NMD. Surveys were electronically distributed to adults living with NMD and their caregivers between 18th May and 26th July 2020. Distribution was through UK disease registries, charity websites, newsletters, and social media. Results: Adults living with NMD receive little information or education that they are likely to develop swallowing difficulties. Most respondents report wanting this information prior to developing these difficulties. Difficulties with swallowing food and medication are common in this group, and instrumental assessment is considered a helpful assessment tool. Both adults living with NMD and caregivers want earlier access to neuromuscular swallowing specialists and training in how best to manage their difficulties. Conclusions: Improvement is needed in the dysphagia healthcare pathway for adults living with NMD to help mitigate any profound physical and psychological consequences that may be caused by dysphagia. Education about swallowing difficulties and early referral to a neuromuscular swallowing specialist are important to pplwNMD and their caregivers. Further research is required to better understand the experiences of pplwNMD and their caregivers to inform the development of dysphagia healthcare pathways.
Analisis Performansi Jaringan dengan Metode Per Connection Queue (PCQ) dan Hierarchical Token Bucket (HTB) di SMK Latanro Enrekang
Authors: Iskandar M. Iqbal , Satra Ramdan , Syafie Lukman 
Published: January 2024

Smk Latanro Enrekang merupakan salah satu sekolah kejuruan yang berada di kota Enrekang. Saat ini ada beberapa guru dan siswa yang memanfaatkan jaringan internet dari sekolah. Namun manajemen bandwidth di sekolah ini belum dapat digunakan secara optimal dalam mencukupi kebutuhan pengguna, dimana ketika banyaknya pengguna akses internet pada saat jam belajar dan kepentingan administrasi akan menyebabkan penggunaan banwdwith menjadi lambat. Salah satu cara untuk mengurangi penurunan performansi adalah dengan mengatur pembagian bandwidth antar pengguna dengan tepat. Penelitian ini bertujuan untuk mengukur performansi jaringan di SMK Latanro Enrekang dengan metode Per Connection Queue (PCQ) dan Hierarchical Token Bucket (HTB) serta menganalisa parameter pengukuran performansi jaringan dengan menggunakan Quality of Service (QoS). Hasil penelitian menunjukkan nilai rata-rata throughput dengan metode PCQ 1,2 Mbps dengan kategori TIPHON “Bagus” serta nilai rata-rata throughput dengan metode HTB 1,0 Mbps dengan kategori TIPHON “Bagus”, nilai rata-rata packet loss dengan metode PCQ 0,3% dengan kategori TIPHON “Sangat Bagus” serta nilai rata-rata packet loss dengan metode HTB 0,3% dengan kategori TIPHON “Sangat Bagus” dan nilai rata-rata delay dengan metode PCQ 6.42 ms dengan kategori TIPHON “Sangat Bagus” serta nilai rata-rata delay dengan metode HTB 5.92 ms dengan kategoriTIPHON “Sangat Bagus”.
SOSTENIBILIDAD DE LA CUENTA CORRIENTE: CAMBIO ESTRUCTURAL Y RAÍCES UNITARIAS
Authors: Donoso Donoso Vicente , Martín Barroso Víctor 
Published: January 2024

La existencia de elevados y persistentes dé?cits exteriores en un conjunto amplio de países desarrollados a lo largo de las últimas décadas, ha incentivado la aparición de diversos estudios que analizan su sostenibilidad. Una parte importante de estos estudios se instrumenta mediante la aplicación de los denominados tests de raíces unitarias. El presente trabajo tiene por objeto utilizar los citados tests, tomando como referencia el caso español, para contrastar si los dé?cits en el largo plazo son sostenibles o no, permitiendo la presencia de cambio estructural en la tendencia estocástica de la serie de saldo por cuenta corriente, así como en su orden de integración. Asimismo, se contempla la posibilidad de que el saldo tenga un comportamiento no lineal. Sobre la base de esta metodología, se muestra que, a lo largo del periodo considerado (1975-2010), la evidencia es contraria a la hipótesis de sostenibilidad del dé?cit exterior español, a partir de la introducción del euro. La metodología empleada en el trabajo es fácilmente extrapolable al estudio de la sostenibilidad exterior de economías, que presentan dé?cits exteriores persistentes como Grecia, Portugal o los Estados Unidos.
Factores determinantes de la emisión de inversión directa extranjera: un proceso de acumulación de capacidades
Authors: Álvarez Isabel , Torrecillas Celia 
Published: January 2024

El proceso de internacionalización de la empresa vía inversión directa extranjera (IDE) obedece a una decisión individual y, como tal, ha sido generalmente analizada desde una perspectiva microeconómica que justifica la emergencia de empresas multinacionales (EMN) en la existencia de determinadas ventajas de propiedad. Los condicionantes de país, por su parte, han intervenido fundamentalmente en la explicación de los factores determinantes de la localización de la IDE. Sin embargo, aún es escasa la evidencia empírica disponible que emana del análisis de los factores determinantes de la emisión de IDE en el plano agregado, aspecto al que se dedica este trabajo. La reciente emergencia de EMN en países en desarrollo acentúa aún más la importancia de analizar tales factores y su relación con la relevancia de las ventajas de propiedad. En este artículo se utiliza una muestra integrada por 48 países, incluyendo tanto economías desarrolladas como en desarrollo. Los resultados permiten afirmar la existencia de un conjunto de factores que desde una perspectiva macro condicionan el proceso de acumulación de capacidades que influye positivamente en las salidas de inversión, y que éstos difieren entre los dos grupos de países estudiados.
El turismo como factor del crecimiento económico: un estudio comparativo de los países del MERCOSUR
Authors: Brida Gabriel Juan , Lanzilotta Bibiana , Pereyra Juan Sebastián , Pizzolon Fiorella 
Published: January 2024

Este artículo estudia la relación entre turismo y crecimiento económico para los cuatro países del bloque regional MERCOSUR. A partir de un análisis empírico, se investiga si el turismo promueve –en el largo plazo– el crecimiento económico, si es la expansión económica la que conduce al crecimiento de la actividad turística, o si existe una relación bidireccional entre ambas variables. Los resultados indican, en primer lugar, que el turismo promueve el crecimiento económico en todas las economías consideradas. En segundo lugar, al estudiar en cada país la elasticidad del PIB respecto al turismo, se encuentra que los valores más elevados corresponden a los países más pequeños (Paraguay y Uruguay), mientras que la mayor economía del bloque (Brasil) presenta la menor elasticidad; Argentina se encuentra entre estos dos extremos. Por último, en casi todos los países, la causalidad es unidireccional (desde la actividad turística al crecimiento); la excepción es Uruguay, en donde la relación hallada es bidireccional.
Impacto de la crisis mundial en el empleo y la productividad de las PYMES: El caso de las grandes economías europeas
Authors: Kokocinska Malgorzata , Rekowski Marek 
Published: January 2024

La crisis económica mundial iniciada en 2008 ha producido efectos econó-micos negativos en muchas áreas de la economía europea. Una de estas áreas se refiere al sector de las PYMES, que desempeñan un papel importante en cada economía debido a su creación de empleo y valor añadido. En este artículo, se muestran los cambios que han tenido lugar en el ámbito del empleo y la productividad laboral en las PYMES de las grandes economías de la Unión Europea, es decir, Alemania, Francia, Italia, Reino Unido, España y Polonia. Para este análisis, las PYMES fueron divididas en tres grupos, micro, pequeñas y medianas empresas. El período de análisis ha sido 2002-2010, y los datos proceden de Eurostat. Este período ya permite observar los efectos de la crisis económica mundial y evaluar la adaptación de los empresarios a las cambiantes condiciones económicas. La evolución del índice de crecimiento del empleo y de la productividad laboral también permite indicar las diferencias entre los seis países. Las diferencias observadas indican indirectamente no solo la importancia de las estructuras económicas sino de la política económi-ca puesta en funcionamiento por cada país.
Long-term results of ablation index guided atrial fibrillation ablation: insights after 5+ years of follow-up from the MPH AF Ablation Registry
Authors: Fitzpatrick N. , Herczeg S. , Hong K. , Seaver F. , Rosalejos L. , Boles U. , Jauvert G. , Keelan E. , O’Brien J. , Tahin T. , Galvin J. , Széplaki G. 
Published: January 2024

BackgroundCatheter ablation (CA) for symptomatic atrial fibrillation (AF) offers the best outcomes for patients. Despite the benefits of CA, a significant proportion of patients suffer a recurrence; hence, there is scope to potentially improve outcomes through technical innovations such as ablation index (AI) guidance during AF ablation. We present real-world 5-year follow-up data of AI-guided pulmonary vein isolation.MethodsWe retrospectively followed 123 consecutive patients who underwent AI-guided CA shortly after its introduction to routine practice. Data were collected from the MPH AF Ablation Registry with the approval of the institutional research board.ResultsOur patient cohort was older, with higher BMI, greater CHA2DS2-VASc scores, and larger left atrial sizes compared to similar previously published cohorts, while gender balance and other characteristics were similar. The probability of freedom from atrial arrhythmia with repeat procedures is as follows: year 1: 0.95, year 2: 0.92, year 3: 0.85, year 4: 0.79, and year 5: 0.72. Age &gt;75 years (p = 0.02, HR: 2.7, CI: 1.14–6.7), BMI &gt;35 kg/m2 (p = 0.0009, HR: 4.6, CI: 1.8–11.4), and left atrial width as measured on CT in the upper quartile (p = 0.04, HR: 2.5, CI: 1–5.7) were statistically significant independent predictors of recurrent AF.ConclusionAI-guided CA is an effective treatment for AF, with 95.8% of patients remaining free from atrial arrhythmia at 1 year and 72.3% at 5 years, allowing for repeat procedures. It is safe with a low major complication rate of 1.25%. Age &gt;75 years, BMI &gt;35 kg/m2, and markedly enlarged atria were associated with higher recurrence rates.
Catheter ablation in patients with atrial fibrillation and dilated cardiomyopathy
Authors: Siow Yoon-Kee , Lin Chin-Yu , Chung Fa-Po , Lin Yenn-Jiang , Chang Shih-Lin , Lo Li-Wei , Hu Yu-Feng , Liao Jo-Nan , Chang Ting-Yung , Tuan Ta-Chuan , Kuo Ling , Wu Cheng-I , Liu Chih-Min , Liu Shin-Huei , Li Guan-Yi , Kuo Ming-Jen , Wu Shang-Ju , Bautista Jose Antonio , Huang Yu-Shan , Nguyen Dinh Son Ngoc , Chen Shih-Ann 
Published: January 2024

IntroductionCatheter ablation is an effective and safe strategy for treating atrial fibrillation patients. Nevertheless, studies on the long-term outcomes of catheter ablation in patients with dilated cardiomyopathy are limited. This study aimed to assess the electrophysiological characteristics of atrial fibrillation patients with dilated cardiomyopathy and compare the long-term clinical outcomes between patients undergoing catheter ablation and medical therapy.MethodPatient baseline characteristics and electrophysiological parameters were examined to identify the predictors of atrial fibrillation recurrence following catheter ablation. The clinical outcomes of catheter ablation and medical therapy were compared using the propensity score matched method.ResultsA total of 343 patients were enrolled, with 46 in the catheter ablation group and 297 in the medical therapy group. Among the catheter ablation group, 58.7% (n = 27) had persistent atrial fibrillation. The recurrence rate of atrial arrhythmia was 30.4% (n = 14) after an average follow-up duration of 7.7 years following catheter ablation. The only predictive factor for atrial fibrillation recurrence after catheter ablation was the left atrial diameter. When compared to medical therapy, catheter ablation demonstrated significantly better outcomes in terms of overall survival, freedom from heart failure hospitalization, improvement in left ventricular ejection fraction, and a greater reduction in left ventricular diameter and left atrial diameter after propensity score matching.ConclusionsTherefore, catheter ablation proves to be effective in providing long-term control of atrial fibrillation in patients with dilated cardiomyopathy. In addition to standard heart failure care, catheter ablation significantly enhanced both morbidity and mortality outcomes and reversed structural remodeling when compared to heart failure medication alone.
Impact of precipitation on Beishan landslide deformation from 1986 to 2023
Authors: Liu Meng , Yang Wentao , Xu Chong , Yang Yuting , Taylor Liam , Shi Peijun 
Published: January 2024

Investigating the response of landslide activity to climate change is crucial for understanding the disastrous effects of climate change on high mountains. However, the lack of long-term, spatial–temporal consistent measurement of landslide activity prohibits the study of this relationship. In this work, we used two methods to derive the time series of a landslide’s deformation and study its relationship with precipitation in the northeastern Tibetan Plateau. The small baseline subset-interferometric synthetic aperture radar (SBAS-InSAR) method with Sentinel-1A images is first applied to derive time series of the landslide’s deformation from 2020 to 2021. A recently developed method to derive cumulative deformations of optical images was used with Landsat 5 and Sentinel-2 images to derive the long-term deformation time series from 1986 to 2023. Centimeter-scale deformations detected by using the InSAR method are mainly located in the upper and eastern parts of the landslide, whereas meter-scale deformations detected by using the optical method are in the middle of the landslide. Time-series results from both methods show that intra-annual initiations of the landslide’s deformation occurred in rainy months (from July to October). Although there seems to be no direct relations between inter-annual deformations and precipitation, significant displacements since 2020 occurred after exceptionally wet years from 2018 (with a record-breaking precipitation year in 2020). With optical images, we found that the maximum cumulative deformation of the landslide has been &gt;35 m since 1986 with major deformations (&gt;20 m) found after 2020, which may indicate an imminent risk to the Lijie town near the toe of the landslide. With climate change, increased precipitation is expected in future, which may trigger more similar landslides in the vicinity of this region. This work demonstrates an executable framework to assess landslide hazard risk under climate change.
Single-cell disulfidptosis regulator patterns guide intercellular communication of tumor microenvironment that contribute to kidney renal clear cell carcinoma progression and immunotherapy
Authors: Xu Kangjie , Li Dongling , Qian Jinke , Zhang Yanhua , Zhang Minglei , Zhou Hai , Hou Xuefeng , Jiang Jian , Zhang Zihang , Sun Hang , Shi Guodong , Dai Hua , Liu Hui 
Published: January 2024

BackgroundDisulfidptosis, an emerging type of programmed cell death, plays a pivotal role in various cancer types, notably impacting the progression of kidney renal clear cell carcinoma (KIRC) through the tumor microenvironment (TME). However, the specific involvement of disulfidptosis within the TME remains elusive.MethodsAnalyzing 41,784 single cells obtained from seven samples of KIRC through single-cell RNA sequencing (scRNA-seq), this study employed nonnegative matrix factorization (NMF) to assess 24 disulfidptosis regulators. Pseudotime analysis, intercellular communication mapping, determination of transcription factor activities (TFs), and metabolic profiling of the TME subgroup in KIRC were conducted using Monocle, CellChat, SCENIC, and scMetabolism. Additionally, public cohorts were utilized to predict prognosis and immune responses within the TME subgroup of KIRC.ResultsThrough NMF clustering and differential expression marker genes, fibroblasts, macrophages, monocytes, T cells, and B cells were categorized into four to six distinct subgroups. Furthermore, this investigation revealed the correlation between disulfidptosis regulatory factors and the biological traits, as well as the pseudotime trajectories of TME subgroups. Notably, disulfidptosis-mediated TME subgroups (DSTN+CD4T-C1 and FLNA+CD4T-C2) demonstrated significant prognostic value and immune responses in patients with KIRC. Multiple immunohistochemistry (mIHC) assays identified marker expression within both cell clusters. Moreover, CellChat analysis unveiled diverse and extensive interactions between disulfidptosis-mediated TME subgroups and tumor epithelial cells, highlighting the TNFSF12-TNFRSF12A ligand-receptor pair as mediators between DSTN+CD4T-C1, FLNA+CD4T-C2, and epithelial cells.ConclusionOur study sheds light on the role of disulfidptosis-mediated intercellular communication in regulating the biological characteristics of the TME. These findings offer valuable insights for patients with KIRC, potentially guiding personalized immunotherapy approaches.
Critical importance of patient-reported outcomes for a comprehensive assessment of psoriatic arthritis patients
Authors: Lo Monaco Marika , Mallaci Bocchio Raffaella , Natoli Giuseppe , Giardina Annarita , Cangemi Ignazio , Scibetta Salvatore , Argano Christiano , Corrao Salvatore 
Published: January 2024

IntroductionPsoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory disease that negatively impacts patients’ quality of life. Patient-reported outcome measures (PROMs) are used to capture patient perspectives in disease assessment, and physicians use the Disease Activity Index for Psoriatic Arthritis (DAPSA) to evaluate disease activity in PsA. The study aimed to assess the relationship between PROMs and the DAPSA score in consecutive outpatients affected by PsA.Materials and methodsA cross-sectional study was conducted from March 2018 to October 2020 at the PsA clinic of the ARNAS Civico in Palermo (Italy), enrolling outpatients with PsA. Patients were assessed for their disease activity according to the DAPSA score, and PROMs, such as PHQ-9, HAQ, FACIT-F, and PsAID, were evaluated. Linear regression analysis evaluated the relationship between the DAPSA Score and the included PROMs.Results158 PsA consecutive peripheral subset psoriatic arthritis outpatients were recruited. The median years of illness was 10.6 (9.3–11.9), and the median DAPSA score was 19.02 (9–33.1). The regression analysis highlighted a strong relationship between the DAPSA score and the PsAID (adjR2 26%, p &lt; 0.0001), the FACIT-F (adjR2 25.4%, p &lt; 0.0001), the HAQ (adjR2 23.7%, p &lt; 0.0001), and PHQ-9 (adjR2 15%, p &lt; 0.0001).ConclusionPROMs are strongly associated with the DAPSA score, but it allows in-depth evaluation of the impact of the disease on different domains of PsA patients’ life.