bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative study exploring the views and perceptions of parents/carers of young children with CF regarding the introduction of CFTR modulator therapy (The REVEAL study; PaRents pErspectiVEs of KAftrio in chiLdren aged 2–5)
Authors: Davies Sioned Haf , Wade Faye , Fogg Heather , Walsh Adam , Southern Kevin W 
Published: January 2025

BackgroundCystic fibrosis (CF) is associated with a historically high treatment burden which causes anxiety and exhaustion for parents of children with CF, especially in the early years of a child’s life. Recently, a new medication, elexacaftor/tezacaftor/ivacaftor (ETI), has become available to some people with CF, which has had a significant impact on the quality of life of older children and adults. This medication will soon be available for children ages 2–5 in the UK. This study investigated parents’ perspectives before their children could start ETI.Method10 parents of young children with CF participated in semistructured online focus groups. The data were analysed using thematic analysis to identify key themes.ResultsThree reviewers identified four main themes: (1) The ‘roller coaster’ of parental emotions: Shock, hope, uncertainty and anticipation, (2) The dark side of the unknown, side effects and burden of decision making, (3) The value of simple pleasures in a life with CF; treatment burden, normality, future, family life and (4) Reforming clinical care in the new era of CF care; support, communication and the future.ConclusionParents experience a range of emotions from the day of diagnosis. While ETI brings hope and positivity, parents are concerned about the medication’s safety. Parents have clear hopes and wishes for their child’s future and reflect on the need for clinicians to consider reforming clinical care in the new era of CF for those eligible for new therapies.
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure
Authors: Neijenhuis Ralph M.L. , Nederend Marieke , van Groningen Anna E. , Jongbloed Monique R.M. , Vliegen Hubert W. , Jukema J. Wouter , Kiès Philippine , Egorova Anastasia D. 
Published: January 2025

BackgroundShort-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan.MethodsIn this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire for Adult’s Health-Related Quality of Life (TAAQOL) at baseline and after starting treatment with sacubitril/valsartan. The TAAQOL was taken at structured outpatient follow-up moments after 6, 12, 24 and 36 months of treatment. Linear mixed effects models were used to evaluate the medium-term changes in 12 QOL domains.ResultsOf 40 sRV failure patients initiated on sacubitril/valsartan, 35 completed the titration phase, and 31 filled in a total of 98 TAAQOL questionnaires (response rate 77.5%). Significant improvements in gross motoric functioning (p=0.008), cognitive function (p=0.002), sleep (p=0.041), social functioning (p<0.001) and daily activities (p=0.001) were observed during follow-up. No significant changes were observed in fine motoric functioning, pain, sexuality, vitality, positive, depressive or aggressive emotions. Of interest, periods with restrictions relating to the COVID-19 pandemic did not significantly influence changes over time in any of the 12 QOL domains.ConclusionsSacubitril/valsartan treatment was associated with persistent medium-term QOL improvements in gross motoric functioning, cognitive function, sleep, social functioning and daily activities domains in sRV failure patients. Self-perceived QOL of sRV failure patients may be amenable to improvement with sacubitril/valsartan.
Warp drives and Martel–Poisson charts
Authors: Chowdhury Abhishek 
Published: January 2025

Abstract
We extend the construction of Alcubierre–Natário class of warp drives to an infinite class of spacetimes with similar properties. This is achieved by utilising the Martel–Poisson charts which closely resembles the Weak Painlevé–Gullstrand form for various background metrics (Mink, AdS, dS). The highlight of this construction is the non-flat intrinsic metric which in three dimensional spacetimes introduce conical singularities at the origin and in higher dimensions generates non-zero Ricci scalar for the spatial hypersurfaces away from the origin. We analyse the expansion/contraction of space and the (NEC) violations associated with these warp drives and find interesting scalings due to the global imprints of the conical defects. Other properties like tilting of light cones, event horizons and several generalisations are also discussed.
High Glucose Treatment Induces Nuclei Aggregation of Microvascular Endothelial Cells via the
foxo1a
-
klf2a
Pathway
Authors: Wang Xiaoning , Kang Xinyi , Li Bowen , Chen Changsheng , Chen Liping , Liu Dong 
Published: January 2025

BACKGROUND:
Hyperglycemia is a major contributor to endothelial dysfunction and blood vessel damage, leading to severe diabetic microvascular complications. Despite the growing body of research on the underlying mechanisms of endothelial cell (EC) dysfunction, the available drugs based on current knowledge fall short of effectively alleviating these complications. Therefore, our endeavor to explore novel insights into the cellular and molecular mechanisms of endothelial dysfunction is crucial for the field.

METHODS:

In this study, we performed a high-resolution imaging and time-lapse imaging analysis of the behavior of ECs in
Tg(kdrl:ras-mCherry::fli1a:nGFP
) zebrafish embryos upon high glucose treatment. Genetic manipulation and chemical biology approaches were utilized to analyze the underlying mechanism of high glucose–induced nuclei aggregation and aberrant migration of zebrafish ECs and cultured human ECs. Bioinformatical analysis of single-cell RNA-sequencing data and molecular biological techniques was performed to identify the target genes of
foxo1a
.

RESULTS:

In this study, we observed that the high glucose treatment resulted in nuclei aggregation of ECs in zebrafish intersegmental vessels. Additionally, the aberrant migration of microvascular ECs in high glucose–treated embryos, which might be a cause of nuclei aggregation, was discovered. High glucose induced aggregation of vascular endothelial nuclei via
foxo1a
downregulation in zebrafish embryos. Then, we revealed that high glucose resulted in the downregulation of
foxo1a
expression and increased the expression of its direct downstream effector,
klf2a
, through which the aberrant migration and aggregation of vascular endothelial nuclei were caused.

CONCLUSIONS:

High glucose treatment caused the nuclei of ECs to aggregate in vivo, which resembles the crowded nuclei of ECs in microaneurysms. High glucose suppresses
foxo1a
expression and increases the expression of its downstream effector,
klf2a
, thereby causing the aberrant migration and aggregation of vascular endothelial nuclei. Our findings provide a novel insight into the mechanism of microvascular complications in hyperglycemia.
Abstract TP281:

Prevalence of stroke in individuals with Migraine: A risk analysis accounting for comorbidities using participant information from the All of Us database
Authors: Seah Nick , Dumitrascu Oana , Schwedt Todd , Wu Teresa , Chong Catherine 
Published: January 2025

Introduction:
We assess the risk of stroke in individuals with and without a migraine diagnosis, adjusting for demographic variables and stroke risk factors using participant information from the All of Us database.

Method:
Diagnoses of migraine, stroke and comorbidities were identified using ICD9 and ICD10 codes. A multivariable logistic regression analysis was performed to assess the association between migraine and risk of stroke adjusting for comorbidities including hypertension, atrial fibrillation, hyperlipidemia, diabetes, tobacco use, depression and demographics (age, sex at birth, race and ethnicity). To compare the prevalence of stroke between individuals with and without migraine, odds ratios using a 95% confidence interval (CI) were calculated.

Results:
Within the
All of Us
database, 31,444 individuals received a migraine diagnosis (female=25,374/81%, male=5,391/17%, other=679/2%; mean (std) age=54.9 (15.6)) and 379,283 did not have a migraine diagnosis (female=222,104/59%, male=149,182/39%, other=7,997/2%; mean (SD) age=55.9 (17.2)), see Figure 1 for detailed demographics.

The migraine cohort had a greater proportion of women (81% vs 59%, p<0.001), a higher proportion of white individuals (61% vs. 55%, p<0.001) fewer African American individuals (15% vs. 19%, p<0.001) and a lower proportion of individuals who were 61 or older (39% vs 45%, p<0.001) compared to the non-migraine cohort.
Compared to the non-migraine cohort, individuals with migraine had significantly higher rates of comorbidities, including depression (13% vs. 4%, p<0.001), diabetes (16% vs. 7%), tobacco use (23% vs. 9%, p<0.001), hyperlipidemia (48% vs. 22%, p<0.001), hypertension (57% vs. 27%, p<0.001), and atrial fibrillation (7% vs. 4%, p<0.001).
A multivariate regression model adjusted for differences between cohort demographics and comorbidities found that individuals with migraine had 2.14 higher odds of overall stroke compared to the non-migraine cohort (OR 2.14, 95% CI [ 2.04, 2.24].

Discussion:
After adjusting for cohort imbalances in demographics and comorbidities, individuals with migraine had a 2.14 times higher risk of stroke compared to those without a migraine diagnosis. Our analysis, using data from the All of Us database, confirms previous findings and suggests that while comorbidities are more prevalent in those with migraine, they do not fully account for the increased stroke risk.
Abstract WP251: Middle meningeal artery embolization using Onyx and particles for chronic subdural hematoma: A single center experience.
Authors: Reid Graham , Noss Eric , Bramlage Luke , Ludwig Bryan , Terry John , Cheng-Ching Esteban 
Published: January 2025

Chronic subdural hematoma (cSDH) represents a relatively treatment-resistant pathologic process with a large impact on quality-adjusted life years. This risk is increased in the elderly, and the prevalence is expected to rise as the population ages. Expectant management and classical surgical treatment are associated with increased recurrence rate as well as complications. Middle meningeal artery (MMA) embolization is being utilized more frequently as adjunctive and primary treatment. It has demonstrated beneficial effects on recurrence and progression of cSDH. Here, we present the outcomes of this technique with different embolic agents in our patient population.
IRB approval was obtained for this study. Retrospectively, all patients at a single institution who underwent endovascular MMA embolization with or without open surgical intervention for cSDH were included. Vulnerable populations were excluded. Demographic and medical data were collected at initial, 1-month, and 3-month time points if available and analyzed for differences with unpaired T-test, paired-T test, and chi-square test.
Between 2020 and 2024, a total of 50 patients were treated with MMA embolization for cSDH. Mean age was 73 years. Majority were male. Most were on antithrombotic therapy. Of these, 34 had history of prior SDH, and 38 had history of head trauma. Of the 50 patients, 29 patients underwent combined open surgery and MMA embolization, while 21 underwent MMA embolization alone. The cSDH was bilateral in 23 patients and unilateral in 27 (13 right, 14 left) for a total of 73 cSDHs. Surgical evacuation was performed in 44 cSDHs. Liquid embolic agent (Onyx) was utilized for 32 patients, while particulate embolic agents (250-500 um) were utilized for 18 patients. Of the patients who had follow-up CTs at 1 month, there were 21 cSDHs treated with particles and 39 with Onyx. There was no significant difference in the proportions of patients undergoing surgery in addition to MMA embolization between the groups treated with Onyx and those treated with particle embolization. Additionally, there was no significant difference in the proportions of treated hemispheres with ≥ 50% reduction or ≥ 75% reduction between those treated with Onyx and those treated with particles.
At our institution, there was no difference in reduction of cSDH with Onyx as compared to particle embolization. MMA embolization was associated with no recurrence or progression of cSDH at 3 months.
Ten-Year Trends in Last Known Well to Arrival Time in Acute Ischemic Stroke Patients: 2014 to 2023
Authors: Ferrone Nicholas G. , Sanmartin Maria X. , O’Hara Joseph , Ferrone Sophia R. , Wang Jason J. , Katz Jeffrey M. , Sanelli Pina C. 
Published: January 2025

BACKGROUND:
Many national initiatives focus on promoting early hospital arrival of patients with acute ischemic stroke (AIS) because treatment effectiveness is time-dependent. However, several studies reported time-delays in hospital arrival, especially during the COVID-19 pandemic. Our purpose was to evaluate the 10-year trends in last known well to arrival (LKWA) time and assess disparities in patients with AIS.

METHODS:
A retrospective study of consecutive patients with AIS in the United States admitted to a large, socioeconomically diverse health care system in the New York metropolitan area was performed from 2014 to 2023. LKWA time groups were categorized according to treatment eligibility: 0 to 4.5, >4.5 to 24, and >24 hours. Demographic and clinical characteristics, treatment utilization, and modified Rankin Scale at discharge were extracted from electronic health records. Trend, bivariable, and multivariable logistic regression analyses were conducted.

RESULTS:

A total of 11 563 patients with AIS were included with 53% (6163) LKWA 0 to 4.5, 34% (3988) LKWA >4.5 to 24, and 12% (1412) LKWA >24 groups. From 2014 to 2023, there was a significant downtrend in the early LKWA 0 to 4.5 (61%–46%) with uptrends in the later LKWA >4.5 to 24 (31%–43%) and LKWA >24 (8%–11%) groups (
P
<0.001). In the LKWA >4.5 groups, the gap widened between racial categories after COVID (2021–2023;
P
=0.004). Compared with LKWA 0 to 4.5, the LKWA >4.5 to 24 group was less likely to receive endovascular thrombectomy (
P
<0.001) and more likely to have worse outcomes (modified Rankin Scale, 2–5;
P
<0.001). LKWA >4.5 groups were more likely to be older >80 years of age (odds ratio, 1.33 [95% CIs, 1.11–1.58]), men (1.11 [1.03–1.20]), Black patients (1.21 [1.09–1.34]), Asian patients (1.20 [1.03–1.39]), Medicaid insurance (1.18 [1.08–1.29]), and low-income <$80 000 (1.39 [1.20–1.61]).

CONCLUSIONS:
In the past decade, there was a significant uptrend in patients with AIS arriving in the late LKWA >4.5 groups. Socioeconomic disparities were observed with a persistent uptrend in non-White patients in the late LKWA >4.5 groups after the COVID pandemic. These findings highlight the need to implement targeted efforts to improve disparities in LKWA time in patients with AIS.
An Ex-Ante Analysis of the Effect of Morocco’s Commitment to African Continental Free Trade Area on Trade with African Countries, Using Panel Data
Authors: Fakhouri Mohamed Yassine , Ait soussane Jihad , Mansouri Zahra 
Published: January 2025

Abstract
This paper presents an ex-ante analysis forecasting the potential effects of the full implementation of the African Continental Free Trade Area (AfCFTA) on trade between Morocco and other African countries. Using panel data from 53 African countries over the period from 1990 to 2022, and employing Dynamic Ordinary Least Squares (DOLS), the findings indicate that a 1-point reduction in the average weighted and effectively applied tariff on Morocco’s exports to African countries is associated with a 0.6 % increase in exports. Similarly, a 1-point reduction in the average weighted and effectively applied tariff on Morocco’s imports from African countries results in a 0.45 % increase in imports. These findings suggest that the effective implementation of AfCFTA could improve Morocco’s trade balance with African countries in the long run.
Understanding the motivations and barriers to adoption of environmentally sustainable activities around Kibale National Park, Uganda
Authors: Ainebyona Bruce , Kendall Corinne , Flauro Aimee , John Tinka , Folta Elizabeth , Perry Laura 
Published: January 2025

Abstract
Kibale National Park (KNP) is a biodiversity hotspot. Covering 795 km2 it is home to the most diverse population of primates in Africa including 13 species and the largest populations of Eastern Chimpanzees (Pan troglodytes schweinfurthii) in East Africa. Rural communities around the park rely heavily on subsistence agriculture and natural resources that surround the park for survival. Population density near the park is greater than 300 people per kilometer, exacerbating pressure on natural resources around and within the park. UNITE for the Environment (UNITE) is a conservation organization working with KNP that provides communities with conservation education programs that address local environmental needs and promotes sustainable solutions to support the protection of this important primate habitat. In prior work, UNITE found considerable variation in how well these sustainable activities are adopted. To understand the factors that influence uptake of different sustainable practices by households, we conducted a community survey on participants’ motivations and barriers. Results highlight a number of factors influencing adoption including education and awareness, access, convenience, economic and direct benefits associated with the practices as well as community influence. These results imply that efforts to promote the widespread adoption of sustainable practices should focus on creating more awareness on sustainable behaviors in the targeted communities, which can change their perceptions and attitudes towards the practices and emphasize the direct benefits that arise from adoption of such practices.
Power Dynamics and Gender Discourse
Authors: Muchova Adela 
Published: January 2025

Abstract
This text explores the anti-gender mobilisation initiatives by certain representatives of the Catholic hierarchy within the Czech media between 2010 and 2022. Drawing from contemporary sociological studies, it recognises anti-gender phenomena as interdisciplinary and transnational. Through an analysis of Czech case studies, the text highlights parallels with other European contexts, such as the utilisation of homophobic and conspiratorial rhetoric, while also noting significant differences, particularly the limited audience in a predominantly secular Czech society. By addressing the portrayal of the Catholic Church concerning issues of homophobia and gender inequality, it posits that the current landscape—where concerned women and minorities are often underrepresented in discussions about the church—reflects broader structural challenges tied to clericalism and hierarchicalism. It calls for meaningful dialogue about the church’s public rhetoric to encourage further discussion on gender issues within the institution, along with the appropriate use of theological anthropology and communication strategies.
Who Creates the World Author?
Authors: Sapiro Gisèle 
Published: January 2025

Abstract
Connecting translation studies and authorship studies, this article offers a theoretical framework for a sociology of world literature, which can enrich the research program on world literature established by Pascale Casanova, David Damrosch, and Franco Moretti. A sociological perspective needs to consider the network of individuals and institutions which contributes to the making of world authorship. If Bourdieu asked: “who created the creator?”, this paper asks: “who created the world author?” Focusing on literary translations, the paper makes first some theoretical propositions to distinguish different categories of actors which take part in transcultural (inter)mediation: intermediaries, translators and mediators. It then examines their respective roles in the two stages of production and reception of literary translations.
An Idealized Parameter Study of Destabilization and Convection Initiation in Coastal Regions. Part II: Onshore Synoptic-Scale Flow
Authors: Boyer Christian H. , Keeler Jason M. 
Published: January 2025

Abstract
While it has been established that pronounced sea-breeze fronts (SBFs) develop under conditions of weak or offshore flow, with the SBF serving as a focus for convection initiation (CI), less is known regarding CI processes during large-scale onshore flow, including the potential existence and influence of embedded SBFs. Challenges that have limited progress in addressing this question include the limited focus on cases under this flow regime and the coarse grid spacing used in prior model-based parameter studies, artificially decreasing the magnitude of convergence or thermodynamic gradients associated with the SBF and potentially leading to substantial errors in the representation of surface fluxes. In Part II of this two-part series, the authors address these prior challenges through execution of a suite of Cloud Model 1 (CM1) large-eddy simulations analyzing the impact of varying the magnitude of the onshore wind component (+2.5 and +5.0 m s−1), and radiative forcing and water surface temperature consistent for summertime in the Great Lakes region. In all simulations, a mesoscale enhancement of onshore flow and return flow was present, with a thermal gradient and convergence collocated with the leading edge of this enhanced flow providing evidence for the presence of a diffuse yet discernible SBF. The SBF progressed inland and separated areas where CI did and did not occur, highlighting the need for increased focus on SBFs and CI in this less-studied flow regime. In conditions of weak onshore flow, surface-based CAPE was larger, CI was more common, and it occurred closer to the coast.
An Idealized Parameter Study of Destabilization and Convection Initiation in Coastal Regions. Part I: Calm or Offshore Synoptic-Scale Flow
Authors: Boyer Christian H. , Keeler Jason M. , Rakoczy Brian C. 
Published: January 2025

Abstract
The influence of large bodies of water on convection initiation (CI) and the environment in which convection evolves is highly complex due to the wide range of parameters that control relevant processes. A substantial focus of sea-breeze front (SBF) CI research has focused on the role of mesoscale boundary or organized boundary layer circulation interactions with SBFs; however, less research has focused on heterogeneities in convective parameters and how those may affect CI coverage, timing, and location. In this two-part series, the authors present a parameter study of SBF CI through Cloud Model 1 (CM1) large-eddy simulations across a parameter space varying the cross-shore wind component and radiative forcing and water surface temperatures consistent with June, July, and August in the Great Lakes region. In Part I of this series, simulations under conditions of calm, weak, and moderate offshore flow (0, −2.5, and −5.0 m s−1) are presented. CI occurred in all calm simulations, with decreased coverage and frequency of CI in weak offshore flow. CI was least frequent during moderate offshore flow, despite stronger convergence, due to a shear profile that favored undercutting by the SBF under conditions of moderate offshore flow. Surface-based convective available potential energy (SBCAPE) maxima developed on the cool side of the SBF, with convection occurring on the cool side of the SBF in some cases. Analyses are presented with a focus on the nature of the SBF, distribution of convective parameters, and their implications on CI.