bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provably secure lightweight certificateless lattice‐based authenticated key exchange scheme for IIoT
Authors: Tan Zuowen , Jiao Jintao , Chen Yanliang 
Published: December 2023

SummaryThrough the Industrial Internet of Things (IIoT), the manufacturing enterprises have significantly enhanced the production efficiency. The transmission of data in IIoT over public channels has brought about information leakage issues. Therefore, it is crucial to agree on a session key among the participants. In recent years, numerous authenticated key exchange (AKE) schemes have been designed. However, those AKE schemes which adopt the certificateless approach to tackle certificate management and key escrow may remain vulnerable to quantum attacks, and other AKE schemes which are based on lattice hard problem so as to achieve the post quantum security may incur key management issues. To simultaneously address the aforementioned challenges, we propose a lightweight certificateless lattice‐based authenticated key exchange (C2LAKE) scheme. Upon the hardness assumptions of the inhomogeneous small integer solution (ISIS) and computational bilateral inhomogeneous small integer solution (CBi‐ISIS) problems, the C2LAKE scheme has been demonstrated to be secure in the eCK model and the random oracle model (ROM). Better trade‐off among security and functionality features, and communication and computation costs make the C2LAKE scheme suitable and applicable in the IIoT environment.
Coalition theory based task scheduling algorithm using DLFC‐NN model
Authors: Mishra Ashis Kumar , Mohapatra Subasish , Sahu Pradip Kumar 
Published: December 2023

SummaryResource management and job scheduling are essential in today's cloud computing world. Due to task scheduling and users' diverse submission of large‐scale requests, co‐located VM instances negatively impacted the performance of leased VM instances. This workload further led to resource rivalry across co‐located VMs. In order to address the aforementioned problems, numerous strategies have been presented, however, they fail to take the asynchronous nature of the cloud environment into account. To address this issue, a novel “CTA using DLFC‐NN model” is proposed. This proposed approach combines the coalition theory and DLFC‐NN techniques by including IRT‐OPTICS for task size clustering, digital metrology based on ionized information (DMBII) for defect detection in virtue machines (VM), and the dynamic levy flight hamster optimization algorithm for processing time optimization of the clusters. However, the implementation of task scheduling in an online environment is limited by a number of presumptions or oversimplifications made by current scheduling systems. As a result, a unique coalition theory is applied to efficiently schedule activities. In addition, the DLFC‐NN model is used to reduce resource consumption, span time, and be highly accurate and energy‐efficient when working on both online and offline jobs. Nevertheless, while optimizing the clusters' overall execution time, earlier approaches only decreased the make‐span time for task scheduling. However, the DLFC‐NN model solves the computation problem by using a fully weighted bipartite graph and the pseudo method to determine the fitness of the least makespan time. The enhanced methodology used in this study reduces the scheduling cost and minimizes job completion times according to different task counts when compared to the existing techniques.
Study of Geometrical, Electronic Structure, Spectral, and NLO Properties of Phenyl‐Based Azo Dyes of Dye Sensitizer for Solar Cells: A Theoretical Study
Authors: Dhivya K.S. , Karthika K. , Jothibasker N. , Srinivasan P. 
Published: December 2023

AbstractThe molecular geometry, electronic structure, and absorption spectra of some important phenyl derivatives are investigated by using DFT and TD‐DFT with B3LYP and CAM‐B3LYP functional. The highest HOMO–LUMO energy gap, Non‐linear optical properties of dipole moment, polarizability, and hyperpolarizability are calculated. In both methods hyperpolarizability PDP values (16.77 × 10−30 and 16.59 × 10−30 esu) are higher than PDNA, PDN, and MPAN dye. The Molecular electrostatic potential shows that PDNA dye has more electronegative potential. Comparing all the dyes, PDP dye shows a higher light harvesting efficiency in the UV–vis region. The vibrational frequencies are assigned based on the potential energy distribution (PED) using the VEDA‐4 program.
Smart pillar[5]arene‐based PDMAEMA/PES beads for selective dye pollutants removal: design, synthesis, chemical‐physical characterization, and adsorption kinetic studies
Authors: Rando Giulia , Sfameni Silvia , Milone Marco , Mezzi Alessio , Brucale Marco , Notti Anna , Plutino Maria Rosaria 
Published: December 2023

AbstractThis article reports on the synthesis of an innovative smart polymer, P5‐QPDMAEMA, opportunely developed with the aim of combining the responsiveness of PDMAEMA polymer and the host‐guest properties of covalently linked pillar[5]arenes. Thanks to a traditional Non‐Induced Phase Separation (NIPS) process performed at various coagulation pH, the blending of P5‐QPDMAEMA with polyethersulfone gave rise to the formation of functional beads for the removal of organic dyes in water. Adsorption tests are carried out on all the produced blend‐based beads by employing two representative dyes, the cationic methylene blue (MB), and the anionic methyl orange (MO). In particular, the P5‐QPDMAEMA based beads, prepared at acidic pH, featured the best MO removal rate (i. e., 91.3 % after 150 minutes starting from a 20 mg ⋅ L−1 solution) and a high selectivity towards the removal of the selected anionic dye. Based on the adsorption kinetics and isotherm calculations, the pseudo‐first order and Freundlich models were shown to be the most suitable to describe the MO adsorption behavior, achieving a maximum adsorption capacity of 21.54 mg ⋅ g−1. Furthermore, zwitterionic beads are obtained by a post‐functionalization of the PDMAEMA and the P5‐QPDMAEMA based beads, to test their removal capability towards both anionic and cationic dyes, as shown.
The role of geoarchaeology in the interpretation of fragmented buildings and occupation surfaces: The case of coastal settlements in northeast Scotland
Authors: Reid Vanessa , Milek Karen , O'Brien Charlotte , Sveinbjarnarson Óskar G. , Noble Gordon 
Published: December 2023

AbstractAround the world, poorly preserved buildings and occupation deposits often represent the primary evidence for archaeological structures and settlements. Integrated geoarchaeological methods, such as soil chemistry and micromorphology, can be used to maximise the information obtained from such deposits regarding site preservation and the use of space. However, archaeologists are often reluctant to apply these methods if they suspect that preservation is poor or stratigraphy is not visible in the field. To assess the role that geoarchaeology can play in the interpretation of fragmented and poorly preserved structures, this paper presents the results of two case studies in which multiple geoarchaeological methods (microrefuse analysis, pH, electrical conductivity, magnetic susceptibility, loss‐on‐ignition, portable XRF and micromorphology) were applied to poorly preserved occupation deposits and fragmented buildings in early medieval coastal settlements in northeast Scotland. Micromorphology proved to be fundamental for recognising and understanding the composition of occupation deposits that had formerly been floor surfaces. It also aided interpretations for the use of space and maintenance practices and improved an understanding of the post‐depositional processes that had affected stratigraphic visibility at the macroscale. When subjected to principal component analysis, the geochemical, magnetic and microrefuse data were able to provide new details about activity areas, and successfully identified and filtered out the effects of post‐medieval contamination. Most significantly, the integrated approach demonstrates that fragmented buildings and poorly preserved occupation surfaces can retain surviving characteristics of the use of space, even if the floor surfaces were not preserved well enough to be clearly defined in the field or in thin section.
Intensification of multiphase systems with a jet‐loop reactor: characterization of mass transfer, mixing time, drop oil size, and biomass growth
Authors: Bourguett‐Rosas Paola Gabriela , Arenas‐García Mario Alfonso , Vergara‐Porras Berenice , Guerrero‐Barajas Claudia , Ordaz Alberto 
Published: December 2023

AbstractBACKGROUNDThe development of processes for transforming vegetable oils into useful products has received increasing attention in the biotechnological field. The reactor used for this purpose should meet adequate mass transfer, mixing, and oil dispersion conditions. In this work, comprehensive research into the use of a jet‐loop reactor as a potential alternative to airlift and stirred tank reactors was conducted in the presence of avocado oil in a water‐air system. Additionally, the assessment of the jet‐loop for biomass growth in the presence of oil was performed.RESULTSThe increase of avocado oil from 1% to 5% v/v resulted in a reduction in the performance of the three reactors. Despite the airlift reactor having the lowest power input, it exhibited the worst performance in terms of mass transfer, mixing, and oil dispersion. The estimation of the energetic oxygen transfer efficiency (Kg O2 KW−1 h−1) allowed the determination that the jet‐loop reactor was superior to the stirred tank. This superiority was attributed to the low values of the mixing time and oil droplet diameter observed in the jet‐loop reactor. Finally, all these parameters had a positive impact on the growth of Wautersia eutropha in the jet‐loop reactor compared with the other two reactors.CONCLUSIONThe results showed that the jet‐loop reactor presented superior performance in most cases compared to the stirred tank and airlift reactors. Particularly, the jet‐loop exhibits an interesting potential to reduce the size of the avocado oil droplets, which could lead to a significative increase in the growth rate of Wautersia eutropha. © 2023 Society of Chemical Industry (SCI).
Immunogenicity and safety of inactivated SARS‐CoV‐2 vaccines in people living with HIV: A longitudinal cohort study
Authors: Li Jie , Nie Ling , Guo Caiping , Deng Yuchuan , Guo Qiong , Pang Can , Xin Ruolei , Li Jia , Lu Hongyan , Huang Chun 
Published: December 2023

AbstractTo clarify the characteristics in immunogenicity and safety of inactivated SARS‐Cov‐2 vaccines among HIV‐infected individuals, a longitudinal cohort study was performed on HIV‐infected and HIV‐uninfected participants with no history of COVID‐19 infection and COVID‐19 vaccine inoculation. Participants information and adverse events were collected. Blood samples were collected on the same day before vaccination, 21 days after the first shot, 28 days after the second shot, 6 months after the second vaccination and 14 days after the third dose to test anti‐receptor‐binding domain IgG antibody, viral load, CD4+, CD8+ T cell count. Our result showed that although HIV‐infected adults with low nadir CD4+ T cell count ≤ 350 cells/mm3 generate significantly lower immune response after three shots of vaccine compared with HIV‐negative controls, 100% of all the HIV‐infected and healthy controls were seroconverted after the third shot. Seroconversion ratio and antibody level of 190 days after two shots of vaccination for HIV‐infected with nadir CD4+ T cell count ≤ 350 were significantly lower than that of healthy controls. No significant difference was found in viral load among blood samples collected at each time points. CD4 and CD4/CD8 ratio value were found increased greatly after each shot of inoculation in HIV‐infected individuals with nadir CD4+ T cell count ≤ 350. Multiple logistic regression analysis showed that among HIV‐infected individuals, PLWH with CD4+ T cell count ≤ 350 were less likely experience seroconversion 21 days after the first shot, and less likely maintained antibody immunity 6 months post 2nd dose. Adverse events after each inoculation were not serious and recovered within 1 week. In conclusion, inactivated COVID‐19 vaccine was safe and effective in people living with HIV after three shots of vaccination. HIV‐infected individuals with low nadir CD4+ T cell count ≤ 350 was associated with a nonoptimal antibody response. Further vaccination strategies could be developed for those with low CD4+ T cell counts.
IL‐36 signaling pathway dysregulation in Crimean–Congo hemorrhagic fever virus patients: A potential therapeutic avenue
Authors: Doğan Kübra , Büyüktuna Seyit A. 
Published: December 2023

AbstractCrimean–Congo hemorrhagic fever (CCHF) is a severe viral disease. The scientific literature is growing, emphasizing the significance of the interleukin (IL)‐36 family in the proinflammatory signaling pathway. However, to date, no research has explored the potential of IL‐36 family members as biomarkers in CCHF. This study aims to bridge this gap by evaluating IL‐36α, IL‐36β, and IL‐36γ levels in CCHF patients and healthy controls and investigating their association with disease severity and prognosis. Sixty confirmed CCHF patients and 29 healthy controls were enrolled in this case‐control study. Serum levels of IL‐36α, IL‐36β, and IL‐36γ were measured using enzyme‐linked immunosorbent assays. Significantly higher levels of IL‐36α and IL‐36β were observed in CCHF patients compared to healthy controls (p < 0.05). However, no statistically significant changes were found in IL‐36γ levels between the two groups. Among the CCHF patients, those who did not survive exhibited significantly elevated IL‐36α and IL‐36γ levels compared to survivors (p < 0.01). Positive correlations were identified between IL‐36α and IL‐36γ levels with activated partial thromboplastin time, and D‐dimer (p < 0.01). Conversely, platelet levels showed a negative correlation with IL‐36α and IL‐36γ levels (p < 0.01). The increased levels of IL‐36α, IL‐36β, and IL‐36γ in patients indicate their participation in proinflammatory reactions in CCHF patients. Understanding the role of IL‐36 family members in CCHF pathogenesis could offer valuable insights into disease progression and facilitate the development of targeted therapeutic strategies.
Sarcoma in patients with Lynch syndrome and response to immunotherapy
Authors: Shehata Michael S. , Lofftus Serena Y. , Park Joon Y. , Singh Arun S. , Federman Noah C. , Eilber Fritz C. , Crompton Joseph G. , McCaw Tyler R. 
Published: December 2023

AbstractBackgroundLynch syndrome (LS) is an autosomal dominant genetic predisposition to multiple malignancies and is characterized by deficient DNA mismatch repair. Increased incidence of sarcomas is not formally ascribed to LS; however, increasing evidence suggests a preponderance of these malignancies in affected families. Sarcomas typically possess a low tumor mutational burden and incite a poor immune infiltrate, thereby rendering them poorly responsive to immunotherapy.MethodsWe searched the University of California, Los Angeles (UCLA) sarcoma program database for patients with a diagnosis of sarcoma and LS from 2016 to 2023. Three such patients were identified and all three were treated with PD1 blockade.ResultsWe present three cases of LS‐associated sarcomas (two soft tissue sarcoma and one osteosarcoma) with increased tumor mutational burdens. These patients were each treated with an anti‐PD1 antibody and experienced a response far superior to that reported for non‐LS‐associated sarcomas.ConclusionsIncreased mutational burden and immune infiltrate are observed for sarcomas associated with LS. Although unselected patients with sarcoma have demonstrated poor response rates to immunotherapy, our findings suggest that patients with Lynch‐associated sarcomas are more likely to respond to treatment with anti‐PD1. These patients should be given consideration for immunotherapy.
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives
Authors: Zhao Jintao , Li Xinming , Ma Tao , Chang Bingbing , Zhang Baoxin , Fang Jianguo 
Published: December 2023

AbstractThe burgeoning prodrug strategy offers a promising avenue toward improving the efficacy and specificity of cytotoxic drugs. Elevated intracellular levels of glutathione (GSH) have been regarded as a hallmark of tumor cells and characteristic feature of the tumor microenvironment. Considering the pivotal involvement of elevated GSH in the tumorigenic process, a diverse repertoire of GSH‐triggered prodrugs has been developed for cancer therapy, facilitating the attenuation of deleterious side effects associated with conventional chemotherapeutic agents and/or the attainment of more efficacious therapeutic outcomes. These prodrug formulations encompass a spectrum of architectures, spanning from small molecules to polymer‐based and organic–inorganic nanomaterial constructs. Although the GSH‐triggered prodrugs have been gaining increasing interests, a comprehensive review of the advancements made in the field is still lacking. To fill the existing lacuna, this review undertakes a retrospective analysis of noteworthy research endeavors, based on a categorization of these molecules by their diverse recognition units (i.e., disulfides, diselenides, Michael acceptors, and sulfonamides/sulfonates). This review also focuses on explaining the distinct benefits of employing various chemical architecture strategies in the design of these prodrug agents. Furthermore, we highlight the potential for synergistic functionality by incorporating multiple‐targeting conjugates, theranostic entities, and combinational treatment modalities, all of which rely on the GSH‐triggering. Overall, an extensive overview of the emerging field is presented in this review, highlighting the obstacles and opportunities that lie ahead. Our overarching goal is to furnish methodological guidance for the development of more efficacious GSH‐triggered prodrugs in the future. By assessing the pros and cons of current GSH‐triggered prodrugs, we expect that this review will be a handful reference for prodrug design, and would provide a guidance for improving the properties of prodrugs and discovering novel trigger scaffolds for constructing GSH‐triggered prodrugs.
Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice
Authors: Wang Xuezhu , Guo Rui , Yu Zhuoli , Zikela Lalai , Li Jiaomei , Li Songtao , Han Qiang 
Published: December 2023

ScopeTorreya grandis kernel has traditionally been used to remove intestinal parasites and increases intestinal motility. However, the effect of Torreya grandis kernel oil (TKO) on constipation has not yet been investigated. Therefore, mouse model is used to investigate the effect of TKO on slow transit constipation (STC) and its possible mechanism.Methods and resultsThe effects of TKO on intestinal motility of STC mice are evaluated by fecal weight, fecal water content, colon length, defecation test, and intestinal propulsion test. The mechanism of TKO alleviating STC is explored by detecting biochemical analysis, histological analysis, western blot, qRT‐PCR, immunohistochemistry, and gut microbiota analysis. The results reveal that TKO effectively promotes defecation and intestinal motility, increases the level of endothelin‐1, and restores the histopathological morphology of the colon under LOP pretreatment. The expression levels of occludin, claudin‐1, and zonula occludens‐1 (ZO‐1) mRNA and protein are up‐regulated in mice receiving TKO treatment. The colonic 5‐hydroxytryptamine 3R/4R (5‐HT3R/5‐HT4R) expressions are also increased by TKO supplementation. Additionally, TKO rescues LOP‐caused disorders of the gut microbiota.ConclusionConsumption of TKO is beneficial to STC recovery, and it can alleviate LOP‐induced STC by up‐regulating the colonic expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R.
Interlaminar and translaminar fracture toughness of 3D‐printed continuous fiber reinforced composites: A review and prospect
Authors: Xiang Jiangyang , Cheng Ping , Wang Kui , Wu Yaxian , Rao Yanni , Peng Yong 
Published: December 2023

AbstractFracture toughness is a critical parameter in the evaluation of a component's structural integrity and damage tolerance. For 3D‐printed continuous fiber reinforced composites (CFRCs) based on the fused deposition modeling (FDM) technique, the fracture behavior differed from that of composites manufactured by traditional processes due to the presence of voids and interfaces at different scales, receiving significant attention. Recently published research attempted to apply various testing standards (for other materials) to investigate the fracture behavior of 3D‐printed CFRCs. In these results, the fracture toughness of CFRCs was influenced by the manufacturing parameters dependent on structural porosity and interfacial bonding quality. This paper reviewed fracture toughness measurement standards compatible with CFRCs, factors influencing fracture behavior, and methods improving the fracture toughness of CFRCs. Lastly, this review explored limitations in current studies focused on fracture toughness measurement of 3D‐printed CFRCs and future perspectives for the fabrication of 3D‐printed CFRCs with improved fracture toughness.Highlights
This review focuses on fracture toughness measurement standards compatible with 3D‐printed continuous fiber reinforced composites (CFRCs).
The manufacturing parameters influencing fracture behavior and methods improving fracture toughness were summarized.
This review explores limitations in current studies focused on fracture toughness measurement of 3D‐printed CFRCs.
Enhanced thermal conductivity of electrically insulating polydimethylsiloxane composites with boron nitride nanosheet and aluminum oxide for thermal management on flexible electronics
Authors: Liu Qing‐qing , Dai Zheng‐xing , Sun De‐xiang , Qi Xiao‐dong , Yang Jing‐hui , Wang Yong 
Published: December 2023

AbstractWith the trend of integration and miniaturization of stretchable electronics, thermal management has been a crucial issue. Developing novel materials with high thermal conductivity (TC) and flexibility is urgent. Herein, we report a stretchable polydimethylsiloxane (PDMS)/boron nitride nanosheet (BNNS)@spherical aluminum oxide (Al2O3) composite with high TC and electrical insulation prepared by a two‐step strategy of sucrose‐template and hot‐pressing. An effective foam‐pressing route benefits the composites to form a three‐dimensional thermally conductive networks, improving the in‐plane TC value of the resultant composite to 4.03 W/(mK) at the filler mass fraction of 35.7 wt% and enhancing to 4.66 W/(mK) under 40% stretching ratio. Meanwhile, the composites can be restored to their former state and retain thermally conductive stability with repeated bending and twisting tests. Moreover, the composites were applied in LED with stretching, exhibiting good heat dissipation performance. These results demonstrate this PDMS composite can be potentially utilized as a high‐performance material to solve thermal management problems in flexible electronics.Highlights
The heat conduction network is prepared by sucrose‐template and hot‐pressing.
BNNS@P‐Al2O3 fillers are self‐assembled via the electrostatic interaction.
The composites exhibit good thermal conduction and superior flexibility.
The thermal conductivity of the composite increases after stretching.
The composites can retain thermal conductive stability after deformation.