bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hagioterapia jako sposób uzdrawiania zranień osobowych
Authors: Werbiński Ireneusz 
Published: January 2024

Samo sformułowanie tytułu artykułu i postawienie problemu badawczego wynikają z interdyscyplinarnych zainteresowań badawczych z dziedziny teologii duchowości i psychologii oraz podjętej praktyki już od lat studenckich, kiedy autor zauważył niewystarczalność metod psychologicznych w uzdrawianiu i leczeniu zranień osobowych. Próbując odkryć przyczynę owej niewystarczalności, autor zauważył, że jednak główne nurty współczesnej psychoterapii przejawiają duże zainteresowanie duchowością, choć – trzeba przyznać – niekoniecznie w wymiarze chrześcijańskim. Artykuł ma strukturę panoramiczną i otwartą i ze względu na ograniczoną objętość tekstu dotyka tylko w sposób skrótowy powyższego zagadnienia. Podjęty problem autor próbuje nakreślić w sposób syntetyczny, oparty na fachowej literaturze, nie dając gotowych rozwiązań, lecz wskazując propozycje wyjścia z sytuacji kryzysowej.
Artykuł składa się z 13 punktów. W punkcie pierwszym autor syntetycznie wyjaśnia terminy, którymi posługuje się w artykule. Kolejny punkt, głównie oparty na wiedzy współczesnej psychologii, przedstawia rozumienie zaburzeń osobowościowych. Następne zagadnienie przedstawia rodzaje zaburzeń osobowościowych, aby w punkcie czwartym podać przyczyny tychże zaburzeń. Ponieważ artykuł uwzględnia również zaburzenia osobowości na poziomie duchowym, więc w punkcie piątym autor omawia zaburzenia osobowości, które są znane z lektury Pisma Świętego. W punkcie szóstym zamieszczony wykres przedstawia sfery uzdrowień. W następnym punkcie są wyliczone czynniki wspomagające leczenie zaburzeń osobowych. W kolejnych punktach artykułu wskazano najpierw na etapy procesu uzdrowienia, a potem na warunki uzdrawiania oraz na istotę uzdrawiania duszy. Końcowe punkty wyjaśniają, na czym polega proces zarówno uzdrawiania i wyleczenia, jak i uzdrawiania i przebaczenia. W punkcie zaś ostatnim zasygnalizowano temat istoty przebaczenia i istoty pojednania.
On the $S$-asymptotically $\omega$-periodic mild solutions for multi-term time fractional measure differential equations
Authors: Gou Haide 
Published: January 2024

In this paper, based on regulated functions and fixed
point theorem, a class of nonlocal problem of multi-term time-fractional measure
differential equations
involving nonlocal conditions in Banach spaces. Firstly, we introduce the concept
of $S$-asymptotically $\omega$-periodic mild solution, on the premise
of by utilizing $(\beta,\gamma_k)$-resolvent family and	measure functional
(Henstock-Lebesgue-Stieltjes integral), the existence of
$S$ -asymptotically $\omega$ periodic mild solutions for the mentioned system
are obtained. Finally, as the application of abstract results, the existence
$S$-asymptotically $\omega$-periodic mild solution for a classes of measure
driven differential equation are discussed.
ICONICIDADE E INFORMATIVIDADE NA CODIFICAÇÃO DO SINTAGMA NOMINAL: UMA ANÁLISE DE NOTÍCIAS SOBRE A CAMPANHA ELEITORAL DE 2022 / ICONICITY AND INFORMATIVITY ON NOMINAL PHRASES ENCONDING: AN ANALYSIS OF NEWS ABOUT 2022 ELECTIONS
Authors: Cordeiro Fernando da Silva , Morais Mateus Sales de 
Published: January 2024

Este trabalho estuda a codificação do sintagma nominal (SN), particularmente em textos do gênero notícia. Temos como principal objetivo analisar, à luz dos princípios de iconicidade e informatividade, as formas de estruturação do Sintagma Nominal e sua possível correlação com fatores de natureza semântico-cognitiva e discursivo-pragmática. O estudo encontra suporte teórico-metodológico na Linguística Funcional Centrada no Uso (LFCU). Metodologicamente, este estudo baseia-se no raciocínio dedutivo e é de natureza quali-quantitativa. O corpus de análise foi constituído por 20 notícias, cujo foco era a campanha dos principais candidatos à Presidência da República em 2022: Luiz Inácio Lula da Silva e Jair Messias Bolsonaro. Foram analisados 264 sintagmas nominais. Os achados revelam que há uma larga preferência por SN lexicais, já que eles se adequam melhor aos propósitos do gênero. Observando a extensão desses SN, os resultados apontam uma maior frequência de SN mínimos, dado que os referentes são amplamente conhecidos. Observamos que o status informacional do referente é crucial para sua codificação no discurso, uma vez que SN mais extensos tendem a aparecer quando o referente é uma informação nova no discurso, enquanto SN menores são identificados em casos de status informacional dado/evocado/disponível ou, ainda, inferível. Dessa forma, o estudo mostra que a estrutura do (SN) está intimamente ligada a fatores semântico-cognitivos e discursivo-pragmáticos, comprovando que a premissa funcionalista de que há uma forte correlação entre forma e função.
EVALUATION OF CLINICAL OUTCOMES AND ACCURACY IN TRANSPEDICULAR SCREW FIXATION USING INTRAOPERATIVE CT-GUIDED NAVIGATION FOR LUMBAR SPONDYLOLISTHESIS
Authors: Vadalà G. , Papalia G.F. , Russo F. , Ambrosio L. , Franco D. , Brigato P. , Papalia R. , Denaro V. 
Published: January 2024

The use of intraoperative navigation and robotic surgery for minimally invasive lumbar fusion has been increasing over the past decade. The aim of this study is to evaluate postoperative clinical outcomes, intraoperative parameters, and accuracy of pedicle screw insertion guided by intraoperative navigation in patients undergoing lumbar interbody fusion for spondylolisthesis. Patients who underwent posterior lumbar fusion interbody using intraoperative 3D navigation since December 2021 were included. Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and Short Form Health Survey-36 (SF-36) were assessed preoperatively and postoperatively at 1, 3, and 6 months. Screw placement accuracy, measured by Gertzbein and Robbins classification, and facet joint infringement, measured by Yson classification, were assessed by intraoperative Cone Beam CT scans performed at the end of instrumentation. Finally, operation time, intraoperative blood loss, hospital stay, and screw insertion time were evaluated. This study involved 50 patients with a mean age of 63.7 years. VAS decreased from 65.8±23 to 20±22 (p<.01). ODI decreased from 35.4%±15 to 11.8%±14 (p<.01). An increase of SF-36 from 51.5±14 to 76±13 (p<.01) was demonstrated. The accuracy of “perfect” and “clinically acceptable” pedicle screw fixation was 89.5% and 98.4%, respectively. Regarding facet violation, 96.8% of the screws were at grade 0. Finally, the average screw insertion time was 4.3±2 min, hospital stay was 4.2±0.8 days, operation time was 205±53 min, and blood loss was 169±107 ml. Finally, a statistically significant correlation of operation time with hospital stay, blood loss and placement time per screw was found. We demonstrated excellent results for accuracy of pedicle screw fixation and violation of facet joints. VAS, ODI and SF-36 showed statistically significant improvements from the control at one month after surgery.Navigation with intraoperative 3D images represents an effective system to improve operative performance in the surgical treatment of spondylolisthesis.
DEPRESSION INFLUENCES POSTOPERATIVE PAIN AND DISABILITY IN PATIENTS UNDERGOING LUMBAR SPINAL FUSION: PRELIMINARY DATA OF A PROSPECTIVE STUDY
Authors: Petrucci G. , Papalia G. F. , Russo F. , Ambrosio L. , Papalia R. , Vadalà G. , Denaro V. 
Published: January 2024

Chronic low back pain (CLBP) is the most common cause of disability worldwide, and lumbar spine fusion (LSF) is often chosen to treat pain caused by advanced degenerative disease when clinical treatment failed certain cases, the post-surgical outcomes are not what was expected. Several studies highlight how important are. In psychological variables during the postoperative spine surgery period. The aim of this study is to assess the role of preoperative depression on postoperative clinical outcomes. We included patients who underwent LSF since December 2021. Preoperative depression was assessed administering Beck Depression Inventory questionnaire (BDI). And pain and disability were evaluated at 1, 3, and 6 months, administering respectively Visual Analogic Scale (VAS) and Oswestry Disability Index (ODI). As statistical analysis Mann-Whitney test was performed. We included 46 patients, 20 female (43,5%) and 26 male (56,5%) with an average age of 64,2. The population was divided in two groups, fixing the BDI cut-off point at 10. Patients with BDI < 10 points (N=28) had normal mental health status, instead patients with BDI > 10 points (N=16) had depressive disorders. At 3 months patients with healthy mental status reported statistically significant reduction of pain (U = 372,5, p = .006) and improvement of disability but without statistical significancy (U = 318, p = 0,137). At 6 months patients without psychological disease reported statistically significant reduction of pain (U = 342, p = 0,039) and disability (U = 372,5, p = 0,006).This study demonstrates the correlation between pre-existing depressive state and poorer clinical outcomes after spine surgery. These results are consistent with the literature. Therefore, during the surgical decision making it is crucial to take psychological variables into account in order to predict the results after surgery and inform patients on the potential influence of mental status.
METAL-ON-METAL HIP PROSTHESIS: A RETROSPECTIVE STUDY OF 681 IMPLANTS WITH A FOLLOW-UP OF BETWEEN 12 AND 22 YEARS
Authors: Ciatti C. , Quattrini F. , Asti C. , Maniscalco P. 
Published: January 2024

Previous scientific studies have highlighted how coupling is an important element affecting total hip arthroplasty's survival.This study aims to evaluate whether metal-on-metal (MOM) coupling could be a statistically significant risk factor.The data from the regional joint registry (Registro dell'Impiantologia Protesica Ortopedica, RIPO) was used for analysis. The data collection accuracy of this registry was 97.2% in 2017.We retrospective evaluate all MOM total hip arthroplasties (THAs) implanted in our department between January 01st 2000 and December 31st 2011. We used a control group composed by all other prosthesis implanted in our Department in the same time lapse.We registered 660 MOM THAs. Mean age of patients was 66.9 years. 603 patients have a >36mm head, while 78 a <36 mm one. Neck modularity was present in half of patients. 676 implants were cementless. We registered 69 revisions, especially due to aseptic mobilization (16 THAs), implant breakage (9 THAs) and periprosthetic fracture (6 THAs).The MOM THAs overall Kaplan-Meier survival rate was 87.2 at 15 years, and the difference between MOM THAs and other implants two curves is statistically significant (p<0.05). Male sex is a significant risk factors. Further evaluations are in progress to establish the presence of any additional risk factors. We think weight and/or BMI may be included in this category.Our study confirms the data currently present in the literature regarding a lower survival of metal-on-metal hip prostheses.The male sex is a statistically significant risk factor (p<0.05), while age, head size and modularity of the prosthetic neck are not statistically significant (p>0.05).Any new finds will be presented at the congress venue.
BIOMECHANICAL AND RADIOLOGICAL ASSESSMENT OF AN ALIF STAND-ALONE DEVICE WITH INTEGRATED SCREWS AND ANGULAR-STABLE LOCKING PLATE AT L5/S1 AND ITS ASSOCIATION WITH LUMBAR BONE MINERAL DENSITY
Authors: Jacob A. , Heumann M. , Zderic I. , Varga P. , Caspar J. , Lauterborn S. , Haschtmann D. , Fekete T. , Gueorguiev B. , Loibl M. 
Published: January 2024

Stand-alone anterior lumbar interbody fusion (ALIF) provides the opportunity to avoid supplemental posterior fixation. This may reduce morbidity and complication rate, which is of special interest in patients with reduced bone mineral density (BMD). This study aims to assess immediate biomechanical stability and radiographic outcome of a stand-alone ALIF device with integrated screws in specimens of low BMD.Eight human cadaveric spines (L4-sacrum) were instrumented with SynFix-LR™ (DePuy Synthes) at L5/S1. Quantitative computed tomography was used to measure BMD of L5 in AMIRA. Threshold values proposed by the American Society of Radiology 80 and 120 mg CaHa/mL were used to differentiate between Osteoporosis, Osteopenia, and normal BMD. Segmental lordosis, anterior and posterior disc height were analysed on pre- and postoperative radiographs (Fig 1). Specimens were tested intact and following instrumentation using a flexibility protocol consisting of three loading cycles to ±7.5 Nm in flexion-extension, lateral bending, and axial rotation. The ranges of motion (ROM) of the index level were assessed using an optoelectronic system.BMD ranged 58–181mg CaHA/mL. Comparison of pre- and postoperative radiographs revealed significant increase of L5/S1 segmental lordosis (mean 14.6°, SD 5.1, p < 0.001) and anterior disc height (mean 5.8mm, SD 1.8, p < 0.001), but not posterior disc height. ROM of 6 specimens was reduced compared to the intact state. Two specimens showed destructive failure in extension. Mean decrease was most distinct in axial rotation up to 83% followed by flexion-extension.ALIF device with integrated screws at L5/S1 significantly increases segmental lordosis and anterior disc height without correlation to BMD. Primary stability in the immediate postoperative situation is mostly warranted in axial rotation. The risk of failure might be increased in extension for some patients with reduced lumbar BMD, therefore additional posterior stabilization could be considered.For any figures or tables, please contact the authors directly.
INFLUENCE OF MG-CYLINDERS ON BONE AND CARTILAGE IN OSTEOARTHRITIS
Authors: Angrisani N. , Helmholz H. , Windhagen H. , von der Ahe C. , Scheper V. , Willumeit-Römer R. , Chathoth B.M. , Reifenrath J. 
Published: January 2024

There are no efficient treatment options for osteoarthritis (OA) that delay further progression. Besides osteoinduction, there is growing evidence of also anti-inflammatory, angiogenetic and neuroprotective effects of biodegradable magnesium-based biomaterials. Their use for the treatment of cartilage lesions in contrast is not well-evaluated yet.Mg-cylinders were analysed in an in vitro and in vivo OA model. In vitro, SCP-1 stem cell line was analysed under inflammatory conditions and Mg-impact. In vivo, small Mg- and WE43 alloy-cylinders (1mm × 0,5mm) were implanted into the subchondral bone of the knee joint of 24 NZW rabbits after establishment of OA. As control, another 12 rabbits received only drill-holes. µCT-scan were performed and assessed for changes in bone volume and density. After euthanasia, cartilage was evaluated macroscopically and histologically after Safranin-O-staining. Furthermore, staining with CD271 directed antibody was performed to assess neuro-reactivity.In vitro, an increased gene expression of extracellular matrix proteins as collagen II or aggrecan even under inflammatory conditions was observed under Mg-impact. In vivo, µCT evaluation revealed twice-elevated values for bone volume in femoral condyles with Mg-cylinders compared to controls while density remained unchanged. Cartilage showed no significant differences between the groups. Mg- and WE-samples showed significantly lower levels of CD271+ cells in the cartilage and bone of the operated joints than in non-operated joints, which was not the case in the Drilling-group. Furthermore, bone in operated knees of Drilling-group showed a strong trend to an increase in CD271+ cells compared to both Cylinder-groups. Counting of CD271+ vessels revealed that this difference was attributable to a higher amount of these vessels.The in vitro results indicate a potential cartilage regenerative activity of the degradable Mg-based material. While so far there was no positive effect on the cartilage itself in vivo, implantation of Mg-cylinders seemed to reduce pain-mediating vessels.Acknowledgements: This work is funded by the German Research Foundation (DFG, project number 404534760). We thank Björn Wiese for production of the cylinders.
REACTIVATION OF THE NUCLEUS PULPOUS CELLS BY PLATELET DERIVATIVES AS A NEW TOOL IN INTERVERTEBRAL DISC REGENERATION
Authors: Nardini M. , Gentili C. , Muraglia A. , Zanirato A. , Ferrari P. , Formica M. , Cancedda R. , Mastrogiacomo M. 
Published: January 2024

Degenerative disc disease, associated to low back pain, afflicts more than 50% of humans, and represents a major healthcare problem, especially for the pathology initiation. Current treatments range from conservative strategies to more invasive surgical techniques, such as disc removal and vertebral fusion. In the Intervertebral Disease (IVD) the nucleus pulposus (NP) degeneration is a key factor for the pathology initiation. Several tissue engineering approaches aiming to restore the appropriate NP cell (NPCs) and matrix content, were attempted by using adult stromal cells either from bone marrow or adipose tissue, chondrocytes, notochordal cells and more recently also pluripotent stem cells. However, none was fully satisfactory since the NP acid and a-vascularized environment appeared averse to the implanted heterologous cells. Several studies demonstrated the efficacy of platelet derivatives such as platelet rich plasma (PRP) in promoting the regeneration of connective tissues. We investigated the efficacy of PRP on NPCs proliferation and differentiation with the goal to propose the direct stimulation of resident cells (stimulation of endogenous cells – less invasive surgical procedure) or the implantation of NPCs expanded in vitro in the presence of PRP as therapeutic agents in IVD degeneration.NPCs were isolated from small fragments of NP explants, cultivated in medium supplemented with PRP or FCS (standard condition control) and characterized by FACS analysis for the expression of the typical mesenchymal stem cells markers CD34, CD44, CD45, CD73, CD90 and CD105. NPCs cultured in PL showed a phenotypic profile like the cells cultured in FCS. However, compared to NPCs expanded in the presence of FCS, NPCs expanded in PRP showed a much better proliferation and differentiation capacity. NPCs differentiation was evaluated by the cell ability to produce an organized metachromatic cartilaginous matrix, confirmed by the positive immunohistochemical staining for chondrogenic markers.
TRAINING WITH A NOVEL DIGITALLY ENHANCED HANDS-ON SURGICAL TRAINING (DEHST) ENHANCES THE PERFORMANCE DURING INTRAMEDULLARY NAIL DISTAL INTERLOCKING
Authors: Pastor T. , Cattaneo E. , Pastor T. , Gueorguiev B. , Windolf M. , Buschbaum J. 
Published: January 2024

Freehand distal interlocking of intramedullary nails remains a challenging task. If not performed correctly it can be a time consuming and radiation expensive procedure. Recently, the AO Research Institute developed a new training device for Digitally Enhanced Hands-on Surgical Training (DEHST) that features practical skills training augmented with digital technologies, potentially improving surgical skills needed for distal interlocking. Aim of the study: To evaluate weather training with DEHST enhances the performance of novices without surgical experience in free-hand distal nail interlocking compared to a non-trained group of novices.20 novices were assigned in two groups and performed distal interlocking of a tibia nail in an artificial bone model. Group 1: DEHST trained novices (virtual locking of five nail holes during one hour of training). Group 2: untrained novices without DEHST training. Time, number of x-rays, nail hole roundness, critical events and success rates were compared between the groups.Time to complete the task (sec.) and x-ray exposure (µGcm2) were significantly lower in Group1 414.7 (290–615) and 17.8 (9.8–26.4) compared to Group2 623.4 (339–1215) and 32.6 (16.1–55.3); p=0.041 and 0.003. Perfect circle roundness (%) was 95.0 (91.1–98.0) in Group 1 and 80.8 (70.1–88.9) in Group 2; p<0.001. In Group 1 90% of the participants achieved successful completion of the task (hit the nail with the drill), whereas only 60% of the participants in group 2 achieved this; p=0.121.Training with DEHST significantly enhances the performance of novices without surgical experience in distal interlocking of intramedullary nails. Besides radiation exposure and operation time the com-plication rate during the operation can be significantly reduced.
PRIMARY BONE TUMOURS AND METASTASES: CLINICAL APPROACH
Authors: Oliveira V. 
Published: January 2024

Primary bone tumors are rare, complex and highly heterogeneous. Its diagnostic and treatment are a challenge for the multidisciplinary team. Developments on tumor biomarkers, immunohistochemistry, histology, molecular, bioinformatics, and genetics are fundamental for an early diagnosis and identification of prognostic factors. The personalized medicine allows an effective patient tailored treatment. The bone biopsy is essential for diagnosis. Treatment may include systemic therapy and local therapy. Frequently, a limb salvage surgery includes wide resection and reconstruction with endoprosthesis, biological or composites. The risk for local recurrence and distant metastases depends on the primary tumor and treatment response.Cancer patients are living longer and bone metastases are increasing. Bone is the third most frequently location for distant lesions. Bone metastases are associated to pain, pathological fractures, functional impairment, and neurological deficits. It impacts survival and patient quality of life. The treatment of metastatic disease is a challenge due to its complexity and heterogeneity, vascularization, reduced size and limited access. It requires a multidisciplinary treatment and depending on different factors it is palliative or curative-like treatment. For multiple bone metastases it is important to relief pain and increases function in order to provide the best quality of life and expect to prolong survival. Advances in nanotechnology, bioinformatics, and genomics, will increase biomarkers for early detection, prognosis, and targeted treatment effectiveness. We are taking the leap forward in precision medicine and personalized care.
DESIGN AND DEVELOPMENT OF A CUSTOM PLATFORM TO GROW AND CHARACTERIZE OSTEOSARCOMA SPHEROIDS
Authors: Lipreri M.V. , Cortini M. , Baldini N. , Avnet S. 
Published: January 2024

Osteosarcoma is a highly malignant primary tumor of bone tissue. The 5-year survival rate of patients with metastasis is below 20% and this scenario is unchanged in the last two decades, despite great efforts in pre-clinical and clinical research. Traditional preclinical models of osteosarcoma do not consider the whole complexity of its microenvironment, leading to poor correlation between in vitro/in vivo results and clinical outcomes. Spheroids are a promising in vitro model to mimic osteosarcoma and perform drug-screening tests, as they (i) reproduce the microarchitecture of the tumor, (ii) are characterized by hypoxic regions and necrotic core as the in vivo tumor, (iii) and recapitulate the chemo-resistance phenomena. However, to date, the spheroid model is scarcely used in osteosarcoma research.Our aim is to develop a customized culture dish to grow and characterize spheroids and to perform advanced drug-screening tests. The resulting platform must be adapted to automated image acquisition systems, to overcome the drawbacks of commercial spheroids platforms.To this purpose, we designed and developed a micro-patterned culture dish by casting agarose on a 3D printed mold from a CAD design. We successfully obtained viable and reproducible homotypic osteosarcoma spheroids, with two different cells lines from osteosarcoma (i.e., 143b and MG-63). Using the platform, we performed viability assays and live fluorescent stainings (e.g., Calcein AM) with low reagent consumption. Moreover, the culture dish was validated as drug screening platform, administrating Doxorubicin at different doses, and evaluating its effect on OS spheroids, in terms of morphology and viability. This platform can be considered an attractive alternative to the highly expensive commercial spheroid platforms to obtain homogeneous and reproducible spheroids in a high-throughput and cost effective mode.