bluuebunny/crossref_metadata_2025_split huggingface dataset:
H3K27ac modification and transcription characteristics of adipose and muscle tissues in Chuxiang Black pig
Authors: Kuang Renzhuo , Xu Zhixiang , Zhou Honghong , Zhang Zhao , Peng Hao , Wang Daoyuan , Xu Xuewen , Zhao Shuhong , Zhao Yunxia , Zhu Mengjin 
Published: February 2024

AbstractThe establishment of high‐quality pork breeds for improving meat quality in the pig industry is needed. The Chuxiang Black (CX) pig is a new breed developed from Chinese local pigs and Western lean pigs that has a high proportion of lean meat and excellent meat quality. However, the characteristics of cis‐regulatory elements in CX pigs are still unknown. In this study, cis‐regulatory elements of muscle and adipose tissues in CX pigs were investigated using ChIP‐seq and RNA sequencing. Compared with the reported cis‐regulatory elements of muscle and adipose tissues, 1768 and 1012 highly activated enhancers and 433 and 275 highly activated promoters in CX muscle and adipose tissues were identified, respectively. Motif analysis showed that transcription factors, such as MEF2A and MEF2C, were core regulators of highly activated enhancers and promoters in muscle. Similarly, the transcription factors JUNB and CUX1 were identified as essential for highly activated enhancers and promoters in CX adipose tissue. These results enrich the resources for the analysis of cis‐regulatory elements in the pig genome and provide new basic data for further meat quality improvement through breeding in pigs.
Controlling Shareholders' Value and Corporate Tax Avoidance*
Authors: Cho Hyungjin , Hyun Jeong‐Hoon , Jung Taejin , Kim Yewon 
Published: February 2024

AbstractThis paper investigates whether and how controlling shareholders' value (i.e., the concentration of controlling shareholders' wealth within a business group) affects corporate tax planning using Korean chaebols. We find that firms with high controlling shareholders' value engage in a lower level of tax avoidance than other affiliates in the business group. We also find that controlling shareholders' concern about the costs of tax avoidance (i.e., regulatory penalties and reputational damages) are potential mechanisms that prevent firms with high controlling shareholders' value from aggressive tax planning. Lastly, we provide the value implication of tax avoidance for firms with high controlling shareholders' value.
Mucinous ovarian carcinoma: A survey of practice in Australia and New Zealand
Authors: Rajadevan Niveditha , Flinkier Ariane , Saunders Hugo , Lee Yeh Chen , Scott Clare , Khaw Pearly , Allan Prue , Davies Claire , Andrews John , Wilson Michelle , Lombard Janine M , Harrison Michelle , Nesfield Heshani , DeFazio Anna , Meniawy Tarek , Gorringe Kylie L 
Published: February 2024

AbstractBackgroundMucinous ovarian carcinoma (MOC) is a rare ovarian cancer with limited evidence to support clinical care.AimsWe undertook a clinician survey to better understand current practice in treating MOC in Australia and New Zealand, and to determine any features associated with variation in care. In addition, we aimed to understand future research priorities.MethodsA RedCap survey was distributed to clinician members of the Australia New Zealand Gynaecological Oncology Group (ANZGOG). Questions included respondent demographics, three case studies and future research priorities. Clinicians were asked questions specific to their speciality.ResultsRespondents (n = 47) were commonly experienced gynae‐oncology specialists, most often surgical (38%) or medical (30%) oncologists. There was good consensus for surgical approaches for stage I disease; however, variation in practice was noted for advanced or recurrent MOC. Variation was also observed for medical oncologists; in early‐stage disease there was no clear consensus on whether to offer chemotherapy, or which regimen to recommend. For advanced and recurrent disease a wide range of chemotherapy options was considered, with a trend away from an ovarian‐type toward gastrointestinal (GI)‐type regimens in advanced MOC. This practice was reflected in future research priorities, with ‘Is a GI chemotherapy regimen better than an ovarian regimen?’ the most highly ranked option, followed by ‘Should stage 1C patients receive chemotherapy?’ConclusionsAlthough the number of respondents limited the analyses, it was clear that chemotherapy selection was a key point of divergence for medical oncologists. Future research is needed to establish well‐evidenced guidelines for clinical care of MOC.
Results of an international survey on the current organization of care for pregnant women with cancer
Authors: Heimovaara Joosje H. , van Calsteren Kristel , Lok Christianne A. R. , Evens Andrew M. , Hoegl Jorge , Ferber Andres , Fernandes Andreina , Vriens Ingeborg , van Zuylen Lia , Amant Frédéric 
Published: February 2024

AbstractThe global incidence of cancer is increasing, including its incidence in women of reproductive age. Still, physicians encounter this situation rarely, which could lead to substandard care. This research sought to explore opportunities to improve future care for pregnant women with cancer, by describing the outcomes of a survey distributed to physicians all over the world focusing on clinical experience with pregnant women with cancer, the organization of care and current gaps in knowledge. We included 249 responses from physicians working across 36 countries. Responses demonstrate a wide variation in the organization of care – generally lacking centralization, and the physicians' acknowledgement of insufficient knowledge on the management of pregnant women with cancer. There is a need for improvement through national centralization and/or establishing advisory boards for cancer in pregnancy. Seeing the paucity of cancer in pregnancy experience, the importance of global multidisciplinary collaboration is emphasized.
Pks‐positive Escherichia coli in tumor tissue and surrounding normal mucosal tissue of colorectal cancer patients
Authors: Miyasaka Toshimitsu , Yamada Takeshi , Uehara Kay , Sonoda Hiromichi , Matsuda Akihisa , Shinji Seiichi , Ohta Ryo , Kuriyama Sho , Yokoyama Yasuyuki , Takahashi Goro , Iwai Takuma , Takeda Kohki , Ueda Koji , Kanaka Shintaro , Ohashi Ryuji , Yoshida Hiroshi 
Published: February 2024

AbstractA significant association exists between the gut microbiome and colorectal carcinogenesis, as well as cancer progression. It has been reported that Escherichia coli (E. coli) containing polyketide synthetase (pks) island contribute to colorectal carcinogenesis by producing colibactin, a polyketide‐peptide genotoxin. However, the functions of pks+ E. coli in initiation, proliferation, and metastasis of colorectal cancer (CRC) remain unclear. We investigated the clinical significance of pks+ E. coli to clarify its functions in CRC. This study included 413 patients with CRC. Pks+ E. coli of tumor tissue and normal mucosal tissue were quantified using droplet digital PCR. Pks+ E. coli was more abundant in Stages 0–I tumor tissue than in normal mucosal tissue or in Stages II–IV tumor tissue. High abundance of pks+ E. coli in tumor tissue was significantly associated with shallower tumor depth (hazard ratio [HR] = 5.0, 95% confidence interval [CI] = 2.3–11.3, p < 0.001) and absence of lymph node metastasis (HR = 3.0, 95% CI = 1.8–5.1, p < 0.001) in multivariable logistic analyses. Pks+ E. coli‐low and ‐negative groups were significantly associated with shorter CRC‐specific survival (HR = 6.4, 95% CI = 1.7–25.6, p = 0.005) and shorter relapse‐free survival (HR = 3.1, 95% CI = 1.3–7.3, p = 0.01) compared to the pks+ E. coli‐high group. Pks+ E. coli was abundant in Stages 0–I CRC and associated with CRC prognosis. These results suggest that pks+ E. coli might contribute to carcinogenesis of CRC but might not be associated with tumor progression.
Equine common variable immunodeficiency: Lessons from 100 clinical cases
Authors: Felippe M. Julia B. 
Published: February 2024

SummaryThe clinical manifestation of recurrent fevers and infections alerts the clinician to the possibility of an underlying immunodeficiency. Common variable immunodeficiency (CVID) in the horse is a rare late‐onset, nonfamilial immunological disorder of B cell depletion and/or dysfunction with resultant inadequate antibody production. The most common clinical presentations in horses with CVID are recurrent upper and/or lower respiratory infections, meningitis and/or ataxia, cholangiohepatitis, infectious colitis, infectious dermatitis and severe gastrointestinal parasitism. Immune‐mediated and lymphoproliferative conditions are additional clinical features. The diagnosis of CVID in horses is based on a persistent hypogammaglobulinaemia primarily caused by a serum IgG concentration below 10.00 g/L in at least two different measurements, often accompanied by a serum IgM concentration below 0.50 g/L. Most horses with CVID show a persistent peripheral blood B cell distribution below 6% of total circulating lymphocytes, indicating severe B cell paucity or depletion, but the B cell distribution can be within the normal reference interval. Post‐mortem findings add diagnostic information about the distribution of B and T cells in lymphoid tissues. Clinical management of horses with immunodeficiency is intense and expensive, and these factors weigh on the difficult decision of elective euthanasia. To date, no genetic mutation has been identified in horse patients with CVID, and the large number of breeds of single‐affected individuals in a same herd or immediate lineage from various parts of the United States and the world do not point at an obvious inheritable mechanism of disease or environmental risk factors. This article describes the clinical and immunological findings in 100 equine cases, and comparisons with the disease in human patients.
Being stranded with fossil fuel reserves? Climate policy risk and the pricing of bank loans
Authors: Delis Manthos D. , Greiff Kathrin de , Iosifidi Maria , Ongena Steven 
Published: February 2024

AbstractDo banks price the risk of stranded fossil fuel reserves? To address this question, we hand collect global data on corporate fossil fuel reserves from 2002 to 2016, match it with syndicated loans, and subsequently compare the loan rate charged to fossil fuel firms — along their climate policy exposure — to other firms. We find that banks price climate policy exposure, especially after 2015. We also uncover that our main effect further increases for loans with longer maturity, that loan size to fossil fuel firms increases, and that ‛Green’ banks also charge higher loan rates to fossil fuel firms.
The atmospheres of massiveness: The politics and times of the maybe in Southern megaregions
Authors: Akoth Steve Ouma , Anwar Nausheen , Bathla Nitin , Cavalcanti Mariana , El‐Husseiny Momen , Güney K. Murat , Irawaty Dian Tri , Kaker Sobia Ahmad , Kihato Caroline Wanjiku , Lawanson Taibat , Saguin Kristian Karlo , Simone AbdouMaliq 
Published: February 2024

AbstractIn this introduction to the special issue on massive urbanisation, the collective that has prepared this issue reviews the thinking and experiences that have been important to them. The reflections centre on the use of ‘massive’ in Jamaican patois, where it has two countervailing meanings. On the one hand, it means an inordinate lack of sensitivity to the real conditions taking place, a sense of extreme self‐inflation beyond reason. On the other, it means a collectivity coming into being without a set form, but reflective of a desire for collaboration and mutuality. Massive urbanisation thus means here both the voluminous expansion of speculative accumulation, extraction of land value, replication of vast inequities and disfunction, and the continuous emergence of new forms of urban inhabitation, a constant remaking of the social field by what has been called the urban majority. All of the contributions attempt to work with this sense of doubleness, amplifying the creation of particular atmospheres of the urban as a materiality of its heterogeneity.
Retailer information sharing with green manufacturer encroachment in a hybrid supply chain
Authors: Lin Xiaogang , Zhu Ying , Lin Zhangzheng , Li Wenzhuo , Lin Qiang* 
Published: February 2024

AbstractWe consider a hybrid supply chain with a manufacturer and an online retailer with rich demand information. The manufacturer invests in green products and sells them not only through retailers that then sell to customers (reselling) but also directly to consumers via retailers by paying a proportional fee (agency selling). The retailer first decides whether to share demand information with the manufacturer, who then decides whether to encroach. We show that a manufacturer is willing to encroach when the entry cost is small if the retailer chooses not to share information. However, with the increase in the entry cost, the manufacturer could still encroach if the retailer shares information. We also find that a manufacturer that is more efficient at producing green products is more likely to encroach. Moreover, when the entry cost is sufficiently small or large, the retailer prefers to share information with the manufacturer when the greening investment efficiency is high or the efficiency is low but the proportional fee is large. Nevertheless, when the entry cost is moderate and the competition intensity is small, sharing information is better for the retailer even if the efficiency is low and the proportional fee is small. Finally, we observe that consumer sensitivity to the direct channel, differences in agency selling price and direct selling price, and imperfect retailer information do not influence decisions in specific circumstances. Furthermore, adjusting the encroachment order or ex post sharing impacts the decision‐making, with the magnitude of impact depending on certain supply chain parameters.
Key elements to support primary healthcare nurses to thrive at work: A mixed‐methods sequential explanatory study
Authors: Moloney Willoughby , Cheung Gordon , Jacobs Stephen 
Published: February 2024

AbstractAimDevelop evidence‐based recommendations for managers to support primary healthcare nurses to thrive at work.DesignA mixed‐methods sequential explanatory design.MethodsNational data were collected in 2020 via an e‐survey based on a meta‐analysis of antecedents of thriving from 213 primary healthcare nurses across New Zealand. Structural equation modelling analysis identified the key factors supporting primary healthcare nurses to thrive. This informed a second open‐ended e‐survey in 2022 of 19 nurses from one primary healthcare organization. The thematic analysis provided recommendations for improving management strategies to support thriving primary healthcare nurses.ResultsThe vitality component of thriving significantly reduced burnout and intention to leave organization and profession. In contrast, the learning component of thriving had a significant positive effect on burnout. The key factors that support thriving at work are empowering leadership and perceived organizational supports (decreases burnout and intention to leave organization and profession through enhanced vitality). Recommendations for improving thriving were made in eight key areas: communication, effective management, professional development, scope of practice, autonomy, effective orientation, reward and work–life balance.ConclusionsVitality is important in reducing burnout and turnover intentions. While learning was identified as increasing burnout, professional development and training for managers were identified as essential. Hence, the vitality dimension of the thriving at work construct should be studied at the dimension level, but more research is needed into the impact of learning on thriving over time. Primary healthcare nurses have identified that empowering leadership and perceived organizational support are critical factors in supporting them to thrive, and they provide specific recommendations for managers to improve these factors in the clinical setting.No Patient or Public ContributionThis study collected data from Registered Nurses only.What Is Already Known

A plethora of existing research focuses on resilience in nurses rather than thriving at work.

Enabling employees to thrive at work contributes to improved well‐being and sustainable organizational performance.

What This Paper Adds

Empowering leadership and perceived organizational support are the key factors that support primary healthcare nurses to thrive at work.

The vitality dimension of the thriving at work construct should be studied at the dimension level, and further research is needed into the impact of learning on thriving over time.

Primary healthcare nurses recommend that managers focus on improving communication, management efficiency, professional development, scope of practice, autonomy, orientation, reward and work–life balance.
Evaluating the usefulness of a wordless picture book for adults with intellectual disabilities about the COVID‐19 vaccination programme using co‐production: The CAREVIS study
Authors: Wythe Helena , Attavar Raj , Jones Julia , Kelly Jackie , Palmer Claire , Jenkins Louise , Dekker Romanie , Fearns Debra , Watkins Scott , Hunt Anne , Pattison Natalie 
Published: February 2024

AbstractAimTo explore the usefulness of a co‐designed wordless book showing processes of receiving COVID‐19 vaccines designed by, and for, adults with intellectual disabilities.MethodsA qualitative evaluation of the resource using mixed methods. Semi‐structured interviews were conducted with people with intellectual disabilities, carers and health professionals about resource content, and use. This was analysed thematically. A survey was circulated to intellectual disabilities networks to understand resource need, use, sharing and content.ResultsUnderstanding the COVID‐19 vaccine was a process, not a single event using one resource. A visual resource had a place in facilitating conversations about vaccines between people with intellectual disabilities and carers. Differing perspectives were expressed regarding personal needs, existing awareness of vaccine programmes and communication preferences. Changes were suggested to improve the suggested storyline and relevance around COVID‐19 restrictions changing.ConclusionA visual resource may help conversations about the COVID‐19 vaccine for people with intellectual disabilities.
Multimodal optical mesoscopy reveals the quantity and spatial distribution of Gram‐positive biofilms in ex vivo tonsils
Authors: Clapperton Megan , Kunanandam Tash , Florea Catalina D. , Douglas Catriona M. , McConnell Gail 
Published: February 2024

AbstractBiofilms are known to be present in tonsils, but little is known about their spatial location and size distribution throughout the tonsil. Studies of the location and distribution of biofilms in tonsil specimens have thus far been limited to either high‐magnification methods such as electron microscopy, which enables high‐resolution imaging but only from a tiny tissue volume, or lower magnification techniques such as light microscopy, which allow imaging of larger specimens but with poor spatial resolution. To overcome these limitations, we report the use of multimodal optical mesoscopy to visualise and quantify the number and spatial distribution of Gram‐positive biofilms in fresh, excised paediatric tonsils. This methodology supports simultaneous imaging of both the tonsil host and biofilms in whole mounts of tissue up to 5 mm × 5 mm × 3 mm with subcellular resolution throughout. A quantitative assessment of 36 tonsil specimens revealed no statistically significant difference between biofilm presence on the tonsil surface and the interior of the tonsil. This new quantitative mesoscale imaging approach may prove useful in understanding the role of biofilms in tonsillar diseases and other infections.
Living the Janus Face: The Promise and Perils of Role‐Distancing for Middle Managers
Authors: Gjerde S. , Alvesson M. 
Published: February 2024

AbstractMiddle managers often find themselves in a challenging position: They have to impress different audiences in somewhat incompatible ways and represent and enact managerial ideals and expectations that may be detrimental to their work identities. This study explores role distancing as an alluring coping strategy. Role distancing – acts that express separateness between the individual and the enacted role – may enable the professional to do management and give an impressive managerial performance, without becoming a manager. This may seem like the perfect strategy to impress others while escaping identity struggles. Or maybe not. In this study we take a closer look at role distancing among a group of middle managers in higher education and focus on one manager, Manny, in particular over a period of time. We find that what first seemed to be a promising strategy applauded by a backstage audience, turns into a problem in need of its own solution, as backstage also becomes a frontstage. The paper contributes to theory about middle managers, role distancing in professional work and front−/backstage acting.
Clinical and imaging predictors for hemorrhagic transformation of acute ischemic stroke after endovascular thrombectomy
Authors: Kuang Yongyao , Zhang Lingtao , Ye Kunlin , Jiang Zijie , Shi Changzheng , Luo Liangping 
Published: February 2024

AbstractBackground and PurposeHemorrhagic transformation (HT) is a common complication of endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS). Our study aims to investigate the clinical and imaging predictors of HT and symptomatic intracranial hemorrhage (sICH) in patients who underwent EVT.MethodsA retrospective analysis of 118 patients undergoing EVT for acute anterior circulation stroke was performed. Potential clinical and imaging predictors of all patients were collected and multivariate logistic regression was performed. The risk prediction system was constructed according to the multivariate logistic regression results.ResultsThe incidence of HT and sICH after EVT were 46.6% and 15.3%, respectively. The multivariate logistic regression results showed that Alberta Stroke Program Early CT Score (ASPECTS) (p = .001, odds ratio [OR] = 0.367, 95% [confidence interval] CI, 0.201‐0.670), collateral status (p<.001, OR = 0.117, 95% CI, 0.042‐0.325), relative cerebral blood flow (CBF) ratio (p = .025, OR = 0.943, 95% CI, 0.895‐0.993), and blood glucose on admission (p = .012, OR = 1.258, 95% CI, 1.053‐1.504) were associated with HT. While for sICH, collateral circulation (p = .007, OR = 0.148, 95% CI, 0.037‐0.589), ASPECTS (p = .033, OR = 0.510, 95% CI, 0.274‐0.946), and blood glucose (p = .005, OR = 1.304, 95% CI, 1.082‐1.573) were independent factors. The predictive model for HT after EVT was established, and the sensitivity and specificity of it were 90.9% and 79.4%, respectively, with the area under the curve of 90.0% (84.5%‐95.4%).ConclusionCollateral status, ASPECTS, relative CBF ratio, and blood glucose on admission were predictors for HT in AIS patients, while collateral status, ASPECTS, and blood glucose on admission were also predictors for sICH. In addition, the established predictive model showed good diagnostic value for prediction of HT after EVT.