bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should I stay or should I go? The cerebral bases of street‐crossing decision
Authors: Baurès Robin , Leblond Solène , Dewailly Andrea , Cherubini Marta , Subramanian Lakshmi Devi , Kearney Joseph K. , Durand Jean Baptiste , Roux Franck Emmanuel 
Published: December 2023

AbstractAn observer willing to cross a street must first estimate if the approaching cars offer enough time to safely complete the task. The brain areas supporting this perception, known as Time‐To‐Contact (TTC) perception, have been mainly studied through noninvasive correlational approaches. We carried out an experiment in which patients were tested during an awake brain surgery electrostimulation mapping to examine the causal implication of various brain areas in the street‐crossing decision process. Forty patients were tested in a gap acceptance task before their surgery to establish a baseline performance. The task was individually adapted upon this baseline level and carried out during their surgery. We acquired and normalized to MNI space the coordinates of the functional areas that influenced task performance. A total of 103 stimulation sites were tested, allowing to establish a large map of the areas involved in the street‐crossing decision. Multiple sites were found to impact the gap acceptance decision. A direct implication was however found mostly for sites within the right parietal lobe, while indirect implication was found for sites within the language, motor, or attentional networks. The right parietal lobe can be considered as causally influencing the gap acceptance decision. Other positive sites were all accompanied with dysfunction in other cognitive functions, and therefore should probably not be considered as the site of TTC estimation.
Role of narL gene in the pathogenesis of Salmonella Typhimurium
Authors: Mani Pashupathi , Priyadarsini Swagatika , K. Channabasappa Nikhil , Sahoo Pravas Ranjan , Singh Rohit , Saxena Meeta , Upmanyu Vikramaditya , Agrawal Ravi Kant , Singh Praveen , Saini Mohini , Kumar Ajay 
Published: December 2023

AbstractSalmonella Typhimurium (STM) is a facultative anaerobe and one of the causative agents of nontyphoidal salmonellosis (NTS). Its anaerobic metabolism is enabled under the hypoxic environment that is encountered inside macrophages and the gut lumen of the host. In both of these niches, free radicals and oxidative intermediates are released by neutrophils as an inflammatory response. These chemical species further undergo reactions to produce nitrate, which is preferably taken up by STM as an electron acceptor in the absence of oxygen. NarL, the response regulator of the two‐component regulatory system NarX/L, and a transcription factor, gets activated under anaerobic nitrate‐rich conditions and upregulates the nitrate reduction during anaerobic respiration of STM. To understand the role of NarL in the pathogenesis of STM, we generated a narL‐knockout (STM:ΔnarL) as well as a narL‐complemented strain of STM. Anaerobically, the mutant displayed no growth defect but a significant attenuation in the swimming (26%) and swarming (61%) motility, and biofilm‐forming ability (73%) in vitro, while these morphotypes got rescued upon genetic complementation. We also observed a downregulation in the expression of genes associated with nitrate reduction (narG) and biofilm formation (csgA and csgD) in anaerobically grown STM:ΔnarL. As compared with wild STM, narL mutant exhibited a threefold reduction in the intracellular replication in both intestinal epithelial cells (INT‐ 407) and monocyte‐derived macrophages of poultry origin. Further, in vivo competitive assay in the liver and spleen of the murine model showed a competitive index of 0.48 ± 0.58 and 0.403668 ± 0.32, respectively, for STM:ΔnarL.
Small and large bowel anatomy is associated with enteral autonomy in infants with short bowel syndrome: A retrospective cohort study
Authors: Sandy Natascha S. , Roberts Amin J. , Wales Paul W. , Toma Ricardo K. , Belza Christina , Dogra Harween , Evans Helen M. , Gattini Daniela , Hind Jonathan , Mercer David , Povondra Jill M. , Turner Justine , Yap Jason , Wong Theodoric , Avitzur Yaron 
Published: December 2023

AbstractBackgroundAchievement of enteral autonomy (EA) is the ultimate treatment goal in pediatric intestinal failure (IF). We aimed to assess predictors of EA in pediatric short bowel syndrome (SBS) and explore the impact of residual small bowel (SB) and large bowel (LB) length on EA.MethodsA retrospective cohort study was performed on infants aged <12 months (n = 367, six centers) with SBS referred between 2010 and 2015. The cohort was stratified based on the achievement of EA. Statistical testing was completed using t‐test, chi‐square, Cox proportional hazards regression model, and Kaplan‐Meier analysis.ResultsEA was achieved in 229 patients. In the multivariable analysis, the percentage of residual LB (hazard ratio [HR] = 1.02; 95% CI = 1.01–1.02) and SB (HR = 1.01; 95% CI = 1.01–1.02) length, presence of the ileocecal valve (HR = 2.02; 95% CI=1.41–2.88), and not coming from a high‐volume transplantation center (HR = 2.42; 95% CI = 1.68–3.49) were positively associated with EA, whereas a negative association was seen with the presence of stoma at the time when shortest remnant was documented (HR = 0.72; 95% CI = 0.52–1.00). EA achievement was significantly different between the anatomical subgroups (log‐rank test P < 0.001) with an EA rate of 80.4% in infants with ≥50% SB and LB (median time 209 days); 62.5% with ≥50% SB and <50% LB (397 days); 58.3% with <50% SB and ≥50% LB (1192 days), and 25.9% with <50% SB and LB. Necrotizing enterocolitis (NEC) was not associated with a better achievement of EA (NEC vs other etiologies: log‐rank test P = 0.33).ConclusionsOverall, 62% of infants with IF secondary to SBS achieved EA over a mean time of follow‐up of 2.3 years. A colon length of >50% can compensate for the loss of small bowel (<50%) and account for similar EA rates as those in children with residual SB > 50%.
Preparation, characterization, and bioavailability evaluation of antioxidant phosvitin peptide‐ferrous complex
Authors: Song Lushan , Zhu Linxian , Qiao Saifeng , Song Li , Zhang Mingran , Xue Tianrui , Lv Binfei , Liu Huiping , Zhang Xiaowei 
Published: December 2023

AbstractBACKGROUNDIron deficiency anemia (IDA) is one of the commonest global nutritional deficiency diseases, and the low bioavailability of iron is a key contributing factor. The peptide‐iron complex could be used as a novel iron supplement to improve iron bioavailability.RESULTSIn this study, antioxidant low molecular weight (<3 kDa) phosvitin peptide (named PP‐4) was separated to prepare a phosvitin peptide‐ferrous complex (named PP‐4‐Fe); then the structural conformation of PP‐4‐Fe was characterized and its bioavailability by in vitro digestion was evaluated. The results showed that PP‐4 had good ferrous‐binding activity with 96.14 ± 2.86 μg Fe2+ mg−1, and had a strong antioxidant effect with 995.61 ± 79.75 μmol TE mg−1 in 2,2'‐azinobis'3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) and 62.3 ± 3.95 μmol FeSO4 mg−1 in ferric ion reducing antioxidant power (FRAP). After ferrous binding, the FRAP activity of PP‐4‐Fe, enhanced by 1.8 times, formed a more ordered structure with an increase in α‐helix and decrease in γ‐random coil. The ferrous binding sites of PP‐4 involved were the amino, carboxyl, imidazole, and phosphate groups. The PP‐4‐Fe complex displayed excellent gastrointestinal stability and antioxidant effects during digestion. The iron dialysis percentage of PP‐4‐Fe was 74.59% ± 0.68%, and increased to 81.10% ± 0.89% with the addition of 0.25 times vitamin C (VC). This indicated that PP‐4‐Fe displayed excellent bioavailability and VC in sufficient quantities had a synergistic effect on improving bioavailability.CONCLUSIONSThis study demonstrated that antioxidant phosvitin peptide was an efficient delivery system to protect ferrous ions and suggested that the phosvitin peptide‐ferrous complex has strong potential as a ferrous supplement. © 2023 Society of Chemical Industry.
Alternatives to English only in scholarly publishing: Emerging trends of language policies among non‐Anglophone journals?
Authors: Li Xiangdong 
Published: December 2023

Key points
Publish in English or perish is becoming a reality in many non‐Anglophone countries.
Non‐Anglophone journals are facing a dilemma: losing appeal to authors/reviewers if published in local languages or losing linguistic/cultural identity if published in English.
This article analyses language policies those journals may use and positions them on a capital‐identity matrix to highlight their advantages and disadvantages.
The article elaborates on two emerging language policies (bilingual publishing and extended English summary), both helping preserve their identity and take advantage of the capital of the English language.
The article provides insights into the pros and cons of different language policies and how to select policies that best support journal survival and development.
Study of sample preparation influence on bacterial lipids profile in matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Authors: Arendowski Adrian , Sibińska Ewelina , Miśta Wioletta , Fijałkowski Piotr , Złoch Michał , Gabryś Dorota , Pomastowski Paweł 
Published: December 2023

AbstractLipids are one of the cell components therefore it is important to be able to accurately assess them. One of the analytical techniques used to study lipid profiles is matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI TOF MS). The present study attempted to select optimal conditions for sample preparation and MALDI MS analysis of bacterial lipidome in both positive and negative ion modes using different extraction protocols—Folch, Matyash, and Bligh & Dyer, solvents used to apply samples, and matrices such as 9‐aminoacridine (9‐AA), α‐cyano‐4‐hydroxycinnamic acid (CHCA), 2,5‐dihydroxybenzoic acid (DHB), 2‐mercaptobenzothiazole (MBT), and 2,4,6‐trihydroxyacetophenone (THAP). The obtained results allowed concluding that DHB or CHCA matrices are suitable for lipid analysis in the positive mode, and in the negative mode THAP or 9‐AA. The most appropriate protocol for extracting lipids from bacterial cells was the Bligh & Dyer method in both ionization modes. The use of the solvent TA30, which was a mixture of acetonitrile and 0.1% trifluoroacetic acid in water, provided on the spectra a significant number of signals from lipids in all groups analyzed, such as fatty acyls, glycerolipids, and glycerophospholipids.
Metastatic pancreatic cancer mimicking medication related osteonecrosis of the jaw—A rare clinical presentation
Authors: Gurav Sandeep , Singh Gurkaran Preet , Ostwal Vikas , Sharma Madhura , Jagtiani Kiran 
Published: December 2023

AbstractPancreatic cancer is a highly aggressive malignancy with a poor prognosis owing to its rapid progression, high mortality rate, and alarming 5‐year survival rate of 5%. Skeletal metastases represent an understated site of metastasis in patients with pancreatic cancer, occurring in about 5%–20% of these patients. The clinical presentation of metastasis to the jaws and osteonecrosis of jaw can exhibit similarities, which may lead to an erroneous diagnosis or create a diagnostic dilemma. We present a case of a 62‐year‐old male patient diagnosed with pancreatic adenocarcinoma and a prior history of bisphosphonate administration who displayed symptoms such as jaw pain, numbness, reduced mouth opening, and an extra‐oral swelling involving a recent tooth extraction site, likely due to medication‐related osteonecrosis of the jaw (ONJ). Despite initial conservative treatment, the patient's symptoms persisted, prompting further investigation. Depending on the specific context and clinical scenario, it is crucial to employ a comprehensive approach such as clinical examination, radiographic imaging, histopathological examination and monitoring the progression of symptoms over time for accurate diagnosis and timely management. This article presents a rare case of metastatic pancreatic cancer mimicking medication related ONJ, highlighting the clinical dilemma and challenges encountered when presenting symptoms and signs are ambiguous. While the prognosis for such cases is generally poor, dentists and healthcare providers should remain vigilant regarding potential sites of metastasis in cases of pancreatic adenocarcinoma.
3D characterization of abnormal grain growth in nanocrystalline nickel
Authors: Zhu Wanquan , Huang Xiaobing , Cai Wei , Huang Tianlin , Wu Guilin , Huang Xiaoxu 
Published: December 2023

AbstractAbnormal grain growth, a pervasive phenomenon witnessed during the annealing of nanocrystalline metals, precipitates a swift diminution of the distinctive properties inherent to such materials. Historically, conventional transmission electron microscopy has struggled to efficiently procure comprehensive five‐parameter crystallographic information from a substantial number of grain boundaries in nanocrystalline metals, thus inhibiting a deeper understanding of abnormal grain growth behavior within nanocrystalline materials. In this study, we utilize a high‐throughput characterization method—three‐dimensional orientation mapping in the TEM (3D‐OMiTEM) to characterize the crystallographic five‐parameter character of grain boundaries with an area of over 3.4 × 106 nm2 in an abnormally grown nanocrystalline nickel sample. When coupled with existing theoretical simulation results, it is discerned that the grain boundary population shows a relatively large scatter when it is correlated to the calculated grain boundary energy; the grain boundaries of abnormally grown grains exhibit lower grain boundary energy compared to those that have not undergone abnormal growth. Merging high‐throughput grain boundary information obtained from three‐dimensional orientation mapping data with grain boundary properties derived from high‐throughput theoretical calculations following the concept of materials genome engineering will undoubtedly facilitate further advancements in comprehending and discerning the interfacial behaviors of crystalline materials.
Multi‐Omics Analysis Reveals Sphingomyelin Accumulation, Glycerolipids Loss, and Disorders of Lipid Metabolism Regulated by Leucine Deprivation in the Liver of Mice
Authors: Yu Haonan , Niu Yaorong , Lei Xinyu , Xie Chunlin , Yan Xianghua 
Published: December 2023

ScopeBranched‐chain amino acids, especially leucine, have been reported to play a role in regulating lipid metabolism. This study aims to examine the effects of leucine deprivation on hepatic lipid metabolism.Methods and resultsC57BL/6 mice are fed with a chow diet (control group, n = 8) or a leucine‐free diet (‐Leu group, n = 8) for 7 days. Histology, lipidomics, targeted metabolomics, and transcriptomics are performed to analyze the liver tissue. Compared to control group, ‐Leu group exhibits a notably reduced liver weight, accompanied by hepatic injury, and disorders of lipid metabolism. The level of sphingomyelin (SM) is significantly increased in the liver of ‐Leu group, while the glycerolipids (GL) level is significantly decreased. The expression of sphingomyelin synthase 1 (SGMS1) is upregulated by leucine deprivation in a time‐dependent manner, leading to hepatic SM accumulation. Moreover, leucine deprivation results in hepatic GL loss via suppressing fatty acid synthase (FASN) and acetyl‐CoA carboxylase 1 (ACC1) expression.ConclusionThe findings demonstrate that leucine deprivation results in abnormal lipid metabolism in the liver, mainly manifested as SM accumulation and GL loss. These results provide insights into the role of leucine in regulating lipid metabolism.
Combination of stem cells and nerve guide conduit for the treatment of peripheral nerve injury: A meta‐analysis
Authors: Cao Siyang , Yihao Wei , Qi Tiantian , Xiong Ao , Liu Peng , Chen Yingqi , Zeng Hui , Yu Fei , Weng Jian 
Published: December 2023

AbstractIntroduction/AimsMany small‐sized, single‐center preclinical studies have investigated the benefits of introducing stem cells into the interior of nerve conduit. The aims of this meta‐analysis are to review and contrast the effects of various types of stem cells in in vivo models used to reconstruct peripheral nerve injuries (PNIs) and to assess the reliability and stability of the available evidence.MethodsA systematic search was conducted using Cochrane Library, Embase, PubMed, and Web of Science to identify studies conducted from January 1, 2000, to September 21, 2022, and investigate stem cell therapy in peripheral nerve reconstruction animal models. Studies that met the relevant criteria were deemed eligible for this meta‐analysis.ResultsFifty‐five preclinical studies with a total of 1234 animals were incorporated. Stem cells demonstrated a positive impact on peripheral nerve regeneration at different follow‐up times in the forest plots of five outcome indicators: compound muscle action potential (CMAP) amplitude, latency, muscle mass ratio, nerve conduction velocity, and sciatic functional index (SFI). In most comparisons, stem cell groups showed substantial differences compared with the control groups. The superior performance of adipose‐derived stem cells (ADSCs) in terms of SFI, CMAP amplitude, and latency (p < .001) was identified.DiscussionThe findings consistently demonstrated a favorable outcome in the reconstruction process when utilizing different groups of stem cells, as opposed to control groups where stem cells were not employed.
Biofouling resistant materials based on micro‐structured surfaces with liquid‐repellent properties
Authors: Jitniyom Thanaphun , Gaddam Anvesh , Williams Georgia , Churm James , Dearn Karl , Banzhaf Manuel , de Cogan Felicity , Dimov Stefan , Gao Nan 
Published: December 2023

AbstractAdhesion of contaminants on various polymer‐based devices during fluid‐substrate interactions is a common problem that can cause biofouling and corrosion. In this study, hierarchical structures with submicron features on polypropylene (PP), high‐density polyethylene (HDPE), and polycarbonate (PC) are fabricated by femtosecond laser ablation. The effect of the hierarchical structures on surface wettability, droplet impact, and bacterial attachment has been examined. Our results demonstrate that the structured polymeric substrates facilitate large contact angles and minimal interfacial adhesion, allowing droplets to roll off at a low angle of inclination below 5°. Further, rendering the hierarchical structures with a low‐surface‐energy coating can enable the surfaces to exhibit superamphiphobic properties. The low interfacial adhesion properties, as accounted by the large contact angles and small contact angle hysteresis, of such surfaces prevent bacterial attachment and biofilm formation. The findings provide a design principle for creating affordable biofouling resistant surfaces with a submicron topography that can be used for engineering and biomedical devices.
Muscle fiber strain rates in the lower leg during ankle dorsi‐/plantarflexion exercise
Authors: Hooijmans Melissa T. , Veeger Thom T. J. , Mazzoli Valentina , van Assen Hans C. , de Groot Jurriaan H. , Gottwald Lukas M. , Nederveen Aart J. , Strijkers Gustav J. , Kan Hermien E. 
Published: December 2023

AbstractStatic quantitative magnetic resonance imaging (MRI) provides readouts of structural changes in diseased muscle, but current approaches lack the ability to fully explain the loss of contractile function. Muscle contractile function can be assessed using various techniques including phase‐contrast MRI (PC‐MRI), where strain rates are quantified. However, current two‐dimensional implementations are limited in capturing the complex motion of contracting muscle in the context of its three‐dimensional (3D) fiber architecture. The MR acquisitions (chemical shift‐encoded water–fat separation scan, spin echo‐echoplanar imaging with diffusion weighting, and two time‐resolved 3D PC‐MRI) wereperformed at 3 T. PC‐MRI acquisitions and performed with and without load at 7.5% of the maximum voluntary dorsiflexion contraction force. Acquisitions (3 T, chemical shift‐encoded water–fat separation scan, spin echo‐echo planar imaging with diffusion weighting, and two time‐resolved 3D PC‐MRI) were performed with and without load at 7.5% of the maximum voluntary dorsiflexion contraction force. Strain rates and diffusion tensors were calculated and combined to obtain strain rates along and perpendicular to the muscle fibers in seven lower leg muscles during the dynamic dorsi‐/plantarflexion movement cycle. To evaluate strain rates along the proximodistal muscle axis, muscles were divided into five equal segments. t‐tests were used to test if cyclic strain rate patterns (amplitude > 0) were present along and perpendicular to the muscle fibers. The effects of proximal‐distal location and load were evaluated using repeated measures ANOVAs. Cyclic temporal strain rate patterns along and perpendicular to the fiber were found in all muscles involved in dorsi‐/plantarflexion movement (p < 0.0017). Strain rates along and perpendicular to the fiber were heterogeneously distributed over the length of most muscles (p < 0.003). Additional loading reduced strain rates of the extensor digitorum longus and gastrocnemius lateralis muscle (p < 0.001). In conclusion, the lower leg muscles involved in cyclic dorsi‐/plantarflexion exercise showed cyclic fiber strain rate patterns with amplitudes that varied between muscles and between the proximodistal segments within the majority of muscles.
Practical clinical guidelines and pharmacological treatment for attention‐deficit hyperactivity disorder in Asia
Authors: Kawabe Kentaro , Horiuchi Fumie , Matsumoto Yu , Inoue Saori , Okazawa Maya , Hosokawa Rie , Nakachi Kiwamu , Soga Junya , Ueno Shu‐Ichi 
Published: December 2023

AbstractAttention‐deficit hyperactivity disorder (ADHD) is characterized by persistent symptoms of inattention, hyperactivity, and impulsivity. Both, stimulant and nonstimulant medications have been approved for the treatment of this disorder. Several Western guidelines recommend the use of prescribed Food and Drug Administration (FDA)‐approved medications for ADHD along with parental training in behavior management and behavioral classroom intervention. In 2022, new Japanese guidelines for ADHD were issued, which recommended school environment management and psychosocial treatment as the first‐line treatment, with pharmacological treatment added as the second‐line treatment. Although Japanese guidelines, including pharmacological treatments, have been established, the guidelines and utilization of ADHD medications across Asian regions are unclear. Therefore, to appropriately evaluate the strategy of pharmacological treatments for ADHD, we investigated Asian regional guidelines for ADHD medication in children. We also reviewed the guidelines in Malaysia, Singapore, India, and the Republic of Korea and found that these guidelines differ from Western guidelines.