bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and optimization of a relativistic magnetron with transparent cathode and output mode
Authors: Sawert David , Vallejos Pablo , Nyberg Frans , Hurtig Tomas 
Published: February 2024

Abstract
This paper outlines the results of particle-in-cell simulations of a relativistic magnetron with six cavities and a transparent cathode configuration. Excitation of the π mode in the interaction region was attained, which in turn led to

$\textrm{TE}_{11}$

mode emission of microwaves to the waveguide. This mode transformation was achieved with a non-symmetric diffraction output, consisting of four large and two small tapered cavities. Simulations were performed with a voltage across the anode-cathode gap varying from 164 to 356 kV, and axial magnetic field strengths between 0.24 and 0.34 T. Maximum efficiency of 37% was obtained with a peak output power of 590 MW, having a voltage of 261 kV and a magnetic field of 0.30 T. Furthermore, a frequency of 2.57 GHz and a rise time of microwaves at the waveguide of 15 ns were demonstrated. The electron leakage current was shown to decrease from ∼10

$\%$

to less than

$1\%$

when employing a longer interaction region, while still exhibiting good performance. Additionally, we show that there is an optimal range of voltages given a magnetic field, for which π mode excitation with high efficiency is attained.
Towards integration? Considering social aspects with large-scale computational models for nature-based solutions
Authors: Schulte Ingrid , Yowargana Ping , Nielsen Jonas Ø. , Kraxner Florian , Fuss Sabine 
Published: February 2024

Abstract

Non-Technical Summary
Information on social aspects of climate change intervention, such as behavioral choices and public acceptance, are often not included in global climate models. As a result, they have been critiqued for not adequately reflecting ‘real world’ conditions. At the same time, these models are important and influential policy tools. To improve these models, calls are being made for more interaction – or integration – between the social science and modelling research communities. Yet, it remains unclear how to achieve this. Responding to this gap, we explore what kind of integration is currently taking place, how, and opportunities for further development.

Technical Summary
The importance of social drivers of climate change interventions, or social aspects, is currently underrepresented in computational modelling projections. These parameters are largely excluded from estimates of technical mitigation potential, feasibility, and tools like integrated assessment models (IAMs) and other large-scale models that influence the development of climate policies and notable bodies like the Intergovernmental Panel on Climate Change. This paper contributes to calls being made within the research community to address this gap and strengthen linkages between modelling practices and social science insights. Using nature-based solutions (NbS) as a framing, we present the results of a critical literature review and interviews with multidisciplinary experts reflecting on the current state of integration around IAMs and opportunities to better capture social aspects within large-scale modelling processes. Our findings confirm the need to incorporate social aspects in IAMs, but highlight that how this happens in practice may depend on context, project objectives, or pragmatic choices rather than conceptual notions about what ‘good’ integration is. Nevertheless, some integration strategies are better than others, and concerns about data limitations and low capacity of the IAM community for engaging in integration can be overcome with sufficient support and complementary efforts from the broader research community.

Social Media Summary
Integrating social aspects in large-scale models requires complementary efforts from the broader research community.
Mixing of Rain and River Water in the Bay of Bengal From Basin‐Scale Freshwater Balance
Authors: Jarugula Sreelekha , Sengupta Debasis , Shroyer Emily , Papa Fabrice 
Published: February 2024

AbstractWe construct freshwater balance in the Bay of Bengal (BoB) within a control volume (CV) bounded by 1,018 kg/m3 isopycnal surface using observations and ocean reanalysis during 2011–2015. Freshwater in CV is maximum in October–November due to monsoonal rain and river inflows, and minimum in April–May. Water lighter than 1,018 kg/m3 is not transported out of BoB, implying that freshwater lost from CV is mixed away entirely within the basin. From freshwater budget, we infer moderate diapycnal mixing rates (∼0.8 × 10−5 m2/s) in boreal spring and summer; in winter (December–January), the rate of freshwater loss to subsurface ocean is 0.015 m/day, corresponding to a median turbulent diffusivity of 4.2 × 10−5 m2/s, with standard error of 25%. We show that enhanced winter mixing across the shallow pycnocline is due to reduced shortwave radiation and subseasonal episodes of surface buoyancy loss when cool, dry northeast monsoon winds blow over BoB.
Climatic Drivers of Ice Slabs and Firn Aquifers in Greenland
Authors: Brils M. , Munneke P. Kuipers , Jullien N. , Tedstone A. J. , Machguth H. , van de Berg W. J. , van den Broeke M. R. 
Published: February 2024

AbstractRecent observations revealed the existence of ice slabs and aquifers on the Greenland ice sheet (GrIS). Both affect the ice sheet's hydrology: ice slabs facilitate runoff and aquifers modulate drainage to the bed. However, their climatic drivers and history remain unclear, as most observations cover only two decades. Here, we present a model simulation of the evolution of GrIS ice slabs and aquifers (1980–2020), evaluated using radar measurements. The results show that accumulation, melt and rain rates are good predictors for the spatial distribution of ice slabs and aquifers. Both features were already present in the late 1980s, and their extent remained relatively constant until the beginning of this century, after which increased melt led to their expansion. We show that almost any transect from the coast to the ice‐sheet interior will cross either an ice slab region, or an aquifer, or both.
Dust Source Activation Frequency in the Horn of Africa
Authors: Kunkelova Tereza , Crocker Anya J. , Wilson Paul A. , Schepanski Kerstin 
Published: February 2024

AbstractMineral dust aerosols play an important role in Earth's climate through interactions with incoming solar radiation, clouds, and the atmosphere. However, dust sources in the Horn of Africa (HoA) and controls on their activation are poorly documented. Here, we use fifteen‐minute Meteosat Second Generation Spinning Enhanced Visible and Infrared Imager dust index images to identify HoA dust source areas and to quantify their activation frequency in 1° × 1° resolution from 2006 to 2010. Around half of all recorded dust events occur in boreal summer, mostly between 8:00 and 16:00 local time. They are driven by meso‐ to regional scale meteorological mechanisms including the breakdown of the nocturnal low‐level jets, land‐sea breezes, and haboobs. By far the most dust‐active region in the HoA is the Afar Triangle (>77% of all recorded dust events) which features the Afar and Danakil depressions and is fed by the Awash River. Despite experiencing strong and persistent southwest summer monsoon winds, dust activation on the Somali Peninsula is less significant. A composite of our map with data for North Africa and westernmost Asia shows that the HoA is a striking latitudinal anomaly with dust activation extending deep into the equatorial belt. Our data also reveal that dust activation is unusually seasonal with ∼40% of events occurring in June and July. Our findings show that aridity and mean wind strength alone are poor predictors of dust activation and underscore the strong control exerted by the availability of readily deflated unconsolidated riverine and lacustrine sediments.
Increasing Occurrence of Sudden Turns From Drought to Flood Over China
Authors: Wang Hao , Wang Shanshan , Shu Xinya , He Yongli , Huang Jianping 
Published: February 2024

AbstractThis study focuses on a new compounding concern, the sudden turn from drought to flood (STDF), that is becoming increasingly prominent. This study investigates the long‐term trends and variability of STDFs in China during 1961–2020. The findings indicate that STDFs are prevalent in north and northeast China, and the Yangtze River Delta (YRD). The probability of a drought being followed by a severe flood is approaching 35% in northern and northeastern China. Since 1961, the number of STDFs in China has increased at a rate of average 2.8 events per decade. This increase mainly has occurred in late spring and early summer. The likelihood that a drought being followed by a significant pluvial is also increasing. The increasing STDF in northern China is mainly attributable to the increasing flood frequency and volatility of precipitation. Changes in the STDF trend is more dependent on the drought frequency in the YRD.
Mapping Geoelectric Field Hazards in Ireland
Authors: Malone‐Leigh John , Campanyà Joan , Gallagher Peter T. , Hodgson Jim , Hogg Colin 
Published: February 2024

AbstractGeoelectric fields are generated at the Earth's surface and can lead to the induction of hazardous geomagnetically induced currents (GIC) in infrastructure like power grids, railways and pipelines during geomagnetic storms. Magnitude and orientation of the geoelectric fields, in relation to the infrastructure, are key features needed to determine the intensity of GIC. Here, we developed the first geoelectric hazard map for the island of Ireland, with the aim of providing detailed information that can help stakeholders mitigate the impact of GICs. The hazard map was developed by modeling and mapping the geoelectric field across Ireland for 28 years (1991–2018) using magnetic field data with magnetotelluric transfer functions. The approach for developing the hazard map calculates the probability of exceeding a hazardous geoelectric field threshold (500 mV/km) during large geomagnetic storms, taking directionality and amplitude into account. We found hazardous geoelectric fields to be mostly localized in areas in the west, south‐west and northern coast. We observed that the geoelectric field have a stronger dominant orientation than the orientation of the geomagnetic field, often constraining the hazardous geoelectric field in particular directions only. We demonstrate a seasonal/diurnal effect is present in the geoelectric field time series. The impact of galvanic distortion was also assessed, and we demonstrate that there is a significant difference in terms of amplitude and direction between both models.
Targeting the m6A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis
Authors: Jung Hae Rim , Lee Jeonghwan , Hong Seung-Pyo , Shin Nayeon , Cho Ara , Shin Dong-Jin , Choi Jin Woo , Kim Jong-Il , Lee Jung Pyo , Cho Sung-Yup 
Published: February 2024

AbstractKidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N6-methyladenosine (m6A) RNA methylation is associated with organ fibrosis. We investigated m6A profile alterations and the inhibitory effect of RNA methylation in kidney fibrosis in vitro (TGF-β-treated HK-2 cells) and in vivo (unilateral ureteral obstruction [UUO] mouse model). METTL3-mediated signaling was inhibited using siRNA in vitro or the METTL3-specific inhibitor STM2457 in vivo and in vitro. In HK-2 cells, METTL3 protein levels increased in a dose- and time-dependent manner along with an increase in the cellular m6A levels. In the UUO model, METTL3 expression and m6A levels were significantly increased. Transcriptomic and m6A profiling demonstrated that epithelial-to-mesenchymal transition- and inflammation-related pathways were significantly associated with RNA m6A methylation. Genetic and pharmacologic inhibition of METTL3 in HK-2 cells decreased TGF-β-induced fibrotic marker expression. STM2457-induced inhibition of METTL3 attenuated the degree of kidney fibrosis in vivo. Furthermore, METTL3 protein expression was significantly increased in the tissues of CKD patients with diabetic or IgA nephropathy. Therefore, targeting alterations in RNA methylation could be a potential therapeutic strategy for treating kidney fibrosis.
Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling
Authors: Lee Seul Gi , Woo Seon Min , Seo Seung Un , Lee Chan-Hyeong , Baek Moon-Chang , Jang Se Hwan , Park Zee Yong , Yook Simmyung , Nam Ju-Ock , Kwon Taeg Kyu 
Published: February 2024

AbstractM2-like tumor-associated macrophages (TAMs) are risk factors for cancer progression and metastasis. However, the mechanisms underlying their polarization are still not fully understood. Although cathepsin D (Cat D) has been reported as a procarcinogenic factor, little is known about the functional role of Cat D in the tumor microenvironment (TME). This study aimed to explore the effect and molecular mechanisms of Cat D in the TME. Cat D knockout (KO) altered the cytokine secretion pattern and induced TAM reprogramming from the M2 to M1 subtype, thereby preventing epithelial-mesenchymal transition and tumor metastasis. Mechanistically, we identified transforming growth factor beta-induced protein (TGFBI) as a Cat D target protein that is specifically associated with TAM polarization. Elevated TGFBI expression in Cat D KO cancer cells resulted in a decline in M2-like TAM polarization. Our RNA-sequencing results indicated that the cancer cell-secreted chemokine CCL20 is a major secretory chemokine for Cat D-TGFBI-mediated TAM polarization. In contrast, Cat D overexpression accelerated TAM polarization into M2-like cells by suppressing TGFBI expression. In addition, the double Cat D and TGFBI KO rescued the inhibitory effects of Cat D KO on tumor metastasis by controlling TAM and T-cell activation. These findings indicated that Cat D contributes to cancer metastasis through TGFBI-mediated TAM reprogramming. Cat D deletion inhibits M2-like TAM polarization through TGFBI-mediated CCL20 expression, reprogramming the immunosuppressive TME. Our results open a potential new avenue for therapy focused on eliminating tumor metastasis.
Exploring the potential of Toxoplasma gondii in drug development and as a delivery system
Authors: Yoon Chanjin , Ham Yu Seong , Gil Woo Jin , Yang Chul-Su 
Published: February 2024

AbstractImmune-mediated inflammatory diseases are various groups of conditions that result in immune system disorders and increased cancer risk. Despite the identification of causative cytokines and pathways, current clinical treatment for immune-mediated inflammatory diseases is limited. In addition, immune-mediated inflammatory disease treatment can increase the risk of cancer. Several previous studies have demonstrated that Toxoplasma gondii manipulates the immune response by inhibiting or stimulating cytokines, suggesting the potential for controlling and maintaining a balanced immune system. Additionally, T. gondii also has the unique characteristic of being a so-called “Trojan horse” bacterium that can be used as a drug delivery system to treat regions that have been resistant to previous drug delivery therapies. In this study, we reviewed the potential of T. gondii in drug development and as a delivery system through current research on inflammation-regulating mechanisms in immune-mediated inflammatory diseases.
Population genomics of the white-beaked dolphin (Lagenorhynchus albirostris): Implications for conservation amid climate-driven range shifts
Authors: Gose Marc-Alexander , Humble Emily , Brownlow Andrew , Wall Dave , Rogan Emer , Sigurðsson Guðjón Már , Kiszka Jeremy J. , Thøstesen Charlotte Bie , IJsseldijk Lonneke L. , ten Doeschate Mariel , Davison Nicholas J. , Øien Nils , Deaville Rob , Siebert Ursula , Ogden Rob 
Published: February 2024

AbstractClimate change is rapidly affecting species distributions across the globe, particularly in the North Atlantic. For highly mobile and elusive cetaceans, the genetic data needed to understand population dynamics are often scarce. Cold-water obligate species such as the white-beaked dolphin (Lagenorhynchus albirostris) face pressures from habitat shifts due to rising sea surface temperatures in addition to other direct anthropogenic threats. Unravelling the genetic connectivity between white-beaked dolphins across their range is needed to understand the extent to which climate change and anthropogenic pressures may impact species-wide genetic diversity and identify ways to protect remaining habitat. We address this by performing a population genomic assessment of white-beaked dolphins using samples from much of their contemporary range. We show that the species displays significant population structure across the North Atlantic at multiple scales. Analysis of contemporary migration rates suggests a remarkably high connectivity between populations in the western North Atlantic, Iceland and the Barents Sea, while two regional populations in the North Sea and adjacent UK and Irish waters are highly differentiated from all other clades. Our results have important implications for the conservation of white-beaked dolphins by providing guidance for the delineation of more appropriate management units and highlighting the risk that local extirpation may have on species-wide genetic diversity. In a broader context, this study highlights the importance of understanding genetic structure of all species threatened with climate change-driven range shifts to assess the risk of loss of species-wide genetic diversity.
Associations of the utilization of household water treatment devices with mortality
Authors: Huang Shuai-Wen , Zhou Hong-Lian , Zeng Rui , Yao Ying 
Published: February 2024

AbstractThis study aimed to investigate the relationship between the utilization of household water treatment devices (UHWTD) and both overall and cause-specific mortality, addressing the lack of comprehensive prospective research in this area. The study was a population-based prospective cohort study using data from the US National Health and Nutrition Examination Survey (NHANES 1999–2010). Among the 30,322 participants included in the study, the group without UHWTD (No UHWTD) was younger but reported worse baseline health compared to the UHWTD group. During an average follow-up period of 14.3 years, 6811 participants died. After adjusting for age, sex, and other covariates, No UHWTD was significantly associated with a higher risk of overall (adjusted hazard ratio [aHR]: 1.221, 95% Confidence Interval [CI]: 1.147–1.300), heart (aHR: 1.405, 95% CI: 1.241–1.589), cancer (aHR: 1.176, 95% CI: 1.003–1.379), Alzheimer’s disease (aHR: 1.404, 95% CI: 1.027–1.919), and nephrosis (aHR: 1.613, 95% CI: 1.026–2.537) mortality compared to UHWTD. Moreover, those main association almost remained after further adjustment for water source. Additionally, we observed a lower detection rate of bromoform, chloroform, bromodichloromethane, and dibromochloromethane in tap water when household water treatment devices was used compared to No UHWTD. The utilization of household water treatment devices in this prospective cohort was associated with modest reductions in the risk of overall, heart, cancer, Alzheimer’s disease, and nephrosis mortality. These findings suggest that the use of household water treatment devices may have the potential to influence health outcomes and extend life expectancy.
Quenched lattice fluctuations in optically driven SrTiO3
Authors: Fechner M. , Först M. , Orenstein G. , Krapivin V. , Disa A. S. , Buzzi M. , von Hoegen A. , de la Pena G. , Nguyen Q. L. , Mankowsky R. , Sander M. , Lemke H. , Deng Y. , Trigo M. , Cavalleri A. 
Published: February 2024

AbstractCrystal lattice fluctuations, which are known to influence phase transitions of quantum materials in equilibrium, are also expected to determine the dynamics of light-induced phase changes. However, they have only rarely been explored in these dynamical settings. Here we study the time evolution of lattice fluctuations in the quantum paraelectric SrTiO3, in which mid-infrared drives have been shown to induce a metastable ferroelectric state. Crucial in these physics is the competition between polar instabilities and antiferrodistortive rotations, which in equilibrium frustrate the formation of long-range ferroelectricity. We make use of high-intensity mid-infrared optical pulses to resonantly drive the Ti–O-stretching mode at 17 THz, and we measure the resulting change in lattice fluctuations using time-resolved X-ray diffuse scattering at a free-electron laser. After a prompt increase, we observe a long-lived quench in R-point antiferrodistortive lattice fluctuations. Their enhancement and reduction are theoretically explained by considering the fourth-order nonlinear phononic interactions to the driven optical phonon and third-order coupling to lattice strain, respectively. These observations provide a number of testable hypotheses for the physics of light-induced ferroelectricity.
Longevity of companion dog breeds: those at risk from early death
Authors: McMillan Kirsten M. , Bielby Jon , Williams Carys L. , Upjohn Melissa M. , Casey Rachel A. , Christley Robert M. 
Published: February 2024

AbstractThe companion dog is one of the most phenotypically diverse species. Variability between breeds extends not only to morphology and aspects of behaviour, but also to longevity. Despite this fact, little research has been devoted to assessing variation in life expectancy between breeds or evaluating the potential for phylogenetic characterisation of longevity. Using a dataset of 584,734 unique dogs located within the UK, including 284,734 deceased, we present variation in longevity estimates within the following: parental lineage (purebred = 1 breed, crossbred ≥ 2 breeds), breed (n = 155), body size (large, medium, small), sex (male, female) and cephalic index (brachycephalic, mesocephalic, dolichocephalic). Survival estimates were then partitioned amongst phylogenetic clades: providing evidence that canine evolutionary history (via domestication and associated artificial selection) is associated with breed lifespan. This information provides evidence to inform discussions regarding pedigree health, whilst helping current/prospective owners, breeders, policy makers, funding bodies and welfare organisations improve decision making regarding canine welfare.
microRNA blood signature for localized radiation injury
Authors: Ancel Lucie , Gabillot Olivier , Szurewsky Chloé , Granger Romain , Sache Amandine , Voyer Frédéric , Gruel Gaëtan , Illiano Stéphane , Benderitter Marc , Le Guen Bernard , Souidi Maâmar , Benadjaoud Mohamed Amine , Flamant Stéphane 
Published: February 2024

AbstractA radiological accident, whether from industrial, medical, or malicious origin, may result in localized exposure to high doses of ionizing radiations, leading to the development of local radiation injury (LRI), that may evolve toward deep ulceration and necrosis of the skin and underlying tissues. Early diagnosis is therefore crucial to facilitate identification and management of LRI victims. Circulating microRNAs (miRNA) have been studied as potential diagnostic biomarkers of several diseases including hematological defects following whole-body irradiation (WBI). This study aims to identify a blood miRNA signature associated with LRI in a preclinical C57BL/6J mouse model of hindlimb irradiation using different 10-MV X-ray doses that lead to injuries of different severities. To this end, we first performed broad-spectrum plasma miRNA profiling, followed by a targeted validation step, on two independent animal cohorts. Using a multivariate sparse partial least square discriminant analysis, we identified a panel of eight circulating miRNAs able to segregate mice according to LRI severity. Interestingly, these miRNAs were previously associated with WBI (miR-150-5p, miR-342-3p, miR-146a-5p), inflammation (miR-18a-5p, miR-148b-3p, miR-532-5p) and skin diseases (miR-139-5p, miR-195-5p). Our results suggest the use of circulating miRNAs as suitable molecular biomarkers for LRI prognosis and diagnosis.