bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dolphins from a prehistoric midden imply long-term philopatry of delphinids around Tokyo Bay
Authors: Kishida Takushi , Namigata Sakiko , Nakanishi Toshimichi , Niiyama Yasukazu , Kitagawa Hiroyuki 
Published: November 2023

Abstract
Cetaceans of the family Delphinidae are widely distributed throughout the global ocean, and it has been suggested that females exhibit philopatry. However, the duration of time that a maternal group of these highly mobile creatures spends inhabiting a particular region remains unknown. The objective of this study is to examine the genetic diversity of delphinids in the past and to shed light on the above question. In this study, we amplified and sequenced the mitochondrial DNA D-loop region from the skeletal remains of delphinids that were excavated from the Shomyoji Midden, a site situated on the western coast of Tokyo Bay and dating to 5000–3000 years before the present. We acquired prehistoric D-loop sequences of seven bottlenose dolphins, six Pacific white-sided dolphins, and a false killer whale. Notably, one or more haplotypes from the prehistoric individuals were detected in the geographically proximate modern conspecific populations across all three species. Whilst the genetic diversity of prehistoric and modern Pacific white-sided dolphin populations appears to be comparable, the modern bottlenose dolphin population demonstrates significantly lower genetic diversity when compared to its prehistoric counterpart in the vicinity of Tokyo Bay. The maternal groups of these species are speculated to have persisted in the same habitat for at least 4000 years.
Characteristic research of regeneration process of particulate filter medium in vibrated fluidized bed
Authors: Liu Bing , He Lixin , Zhao Xianglong , Guo Yi 
Published: November 2023

Abstract
The vibrational fluidized bed is innovatively adopted to regenerate the particulate filter medium for the purification of crude synthesis gas from the coal gasification process. Characteristic research of vibrated fluidized beds during dust-containing particulate filter medium regeneration has been carried out. The ideal transport model of particulate filter medium on the distributor is established and verified by using experiments. The mean residence time of the particulate filter medium can be reduced by 72% from 5.5 to 1.5 min with an increase in the working frequency from 50 to 60 Hz. The thickness of the bed layer is linearly increased with the feeding rate of the particulate filter medium under ideal working conditions. The resistance models of the fluidizing air are built up and validated, and they can be used to calculate the pressure drop of the static bed layer of the particulate filter medium on the fluidizing air distributor, which is the maximum value of the dynamic bed layer with the same thickness. The fluidizing air makes the mean residence time of the particulate filter medium decrease by 50% and reduces the difference in the particulate mean residence time under different feeding-rate conditions. The regeneration effect of dust-containing filter medium particles in a vibrated fluidized bed is evaluated. Fluidizing air with superficial velocity ranging from 0 to 0.6~0.9 m·s–1 makes the regeneration efficiency increase from 29.41% to 70.59~88.24%. This article provides a reference for the industrial application of a vibrated fluidized bed for the particulate filter medium recycling system.
The Opacity of the World: Zadie Smith’s Swing Time
Authors: Nandi Miriam 
Published: November 2023

Abstract
Zadie Smith’s novel Swing Time explores the complex ways in which women relate to each other across cultural difference and generational gaps, as mothers and daughters, as rivals and friends. My article traces the friction between Black feminist group solidarity and aesthetic distance in Swing Time to suggest that the novel can be brought into dialogue with a postcolonial aesthetics of opacity, as coined by Édouard Glissant. The tension between opacity and transparency is the organizing principle of Swing Time, as the novel engages with movement and change, postcolonial spaces, and the mysteries of friendship, while vacillating between ironic narrative commentary and a more elusive aesthetics of concealment. Reading Smith’s work through a Glissantian lens also sheds light on affinities between her essayistic writing and her fiction.
An ingenious musical machine from the imagination of Leonardo da Vinci
Authors: Chinaglia Walter 
Published: November 2023

Abstract
This article is based on a talk I was asked to give during the conference Leonardo, la musica, la scena (Leonardo: the music and the scene) held at the Accademia di Brera, Milan, in November 2019. On that occasion I was able to illustrate my wooden reconstruction of Leonardo’s portative organ, as illustrated on fol.76r of the codex Madrid II. In the article I present and analyse Leonardo’s drawings of this organ in their original context, as well as exploring the distinctive traits of the instrument. With the aim of making possible a historically informed reconstruction, I identify an appropriate interpretative methodology and principles of construction consistent with the historical period in which Leonardo worked, both as musicus and maker of instruments. At the same time I trace an analogy with the portative organ of the late Middle Ages. For this instrument, which works in a very similar way to the late medieval portative organ, some traits have been derived from the portative organ, in particular the scaling of the pipes. Finally, individual parts of Leonardo’s organ design are interpreted and their modern reconstruction illustrated, leading to the presentation of the complete instrument.
Explicating Ageism in the Productive Aging Framework
Authors: Morrow-Howell Nancy , Gonzales Ernest 
Published: November 2023

Abstract
This essay argues for a fuller integration of ageism and age discrimination into the productive aging framework. We briefly review the productive aging scholarship and the extent to which ageism has been considered in regard to working, volunteering, education, and caregiving. We suggest that ageism has not been adequately considered, and we identify how it permeates productive engagement in later life. We introduce modifications to the productive aging framework to more directly capture the roles of ageism and age discrimination in activity engagement and the outcomes achieved. We argue for the integration of key concepts from minority stress theory and critical race theory that may yield important insights for an increasingly diverse older population. We conclude with research directions that will guide intervention development to reduce ageism at the societal, organizational, and individual level.
Innovation and the labor market: theory, evidence, and challenges
Authors: Corrocher Nicoletta , Moschella Daniele , Staccioli Jacopo , Vivarelli Marco 
Published: November 2023

Abstract
This paper deals with the complex relationship between innovation and the labor market, analyzing the impact of new technological advancements on overall employment, skills, and wages. After a critical review of the extant literature and the available empirical studies, novel evidence is presented on the distribution of labor-saving automation [namely robotics and artificial intelligence (AI)], based on natural language processing of US patents. This mapping shows that both upstream high-tech providers and downstream users of new technologies—such as Boeing and Amazon—lead the underlying innovative effort.
Assessing the impact of discordant antibiotic treatment on adverse outcomes in community-onset UTI: a retrospective cohort study
Authors: Aryee Anna , Rockenschaub Patrick , Robson John , Ahmed Zaheer , Nic Fhogartaigh Caoimhe , Ball David , Hayward Andrew , Shallcross Laura 
Published: November 2023

Abstract

Objectives
To investigate the risk of adverse outcomes following discordant antibiotic treatment (urinary organism resistant) for culture-confirmed community-onset lower urinary tract infection (UTI).

Methods
Cohort study using routinely collected linked primary care, secondary care and microbiology data from patients with culture-confirmed community-onset lower UTI (COLUTI). Antibiotic treatment within ±3 days was considered concordant if the urinary organism was sensitive and discordant if resistant.
The primary outcome was the proportion of patients experiencing urinary infection-related hospital admission (UHA) within 30 days. Secondary outcomes were the proportion of patients experiencing reconsultation within 30 days, and the odds of UHA and reconsultation following discordant treatment, adjusting for sex, age, risk factors for complicated UTI, previous antibiotic treatment, recurrent UTI and comorbidities.

Results
A total of 11 963 UTI episodes in 8324 patients were included, and 1686 episodes (14.1%, 95% CI 13.5%–14.7%) were discordant. UHA occurred in 212/10 277 concordant episodes (2.1%, 95% CI 1.8%–2.4%) and 88/1686 discordant episodes (5.2%, 95% CI 4.2%–6.4%). Reconsultation occurred in 3961 concordant (38.5%, 95% CI 37.6%–39.5%) and 1472 discordant episodes (87.3%, 95% CI 85.6%–88.8%). Discordant treatment compared with concordant was associated with increased odds of UHA (adjusted OR 2.31, 95% CI 1.77–3.0, P &lt; 0.001) and reconsultation (adjusted OR 11.25, 95% CI 9.66–13.11, P &lt; 0.001) on multivariable analysis. Chronic kidney disease and diabetes mellitus were also independently associated with increased odds of UHA.

Conclusions
One in seven COLUTI episodes in primary care were treated with discordant antibiotics. In higher risk patients requiring urine culture, empirical antibiotic choice optimization could meaningfully reduce adverse outcomes.
Inhibitor activity of Lactiplantibacillus plantarum LP5 on thermotolerant campylobacter with different biofilm-forming capacities
Authors: Ruiz María J , Sirini Noelí E , Stegmayer María Á , Soto Lorena P , Zbrun María V , Olivero Carolina R , Werning María L , Acosta Federico F , Signorini Marcelo L , Frizzo Laureano S 
Published: November 2023

Abstract

Aims
To evaluate the biofilm-forming capacity of thermotolerant Campylobacter (TC) strains from poultry production and to analyse the inhibitory capacity of Lactiplantibacillus plantarum LP5 against TC on different materials.

Methods and results
Biofilm-forming capacity by Campylobacter jejuni and Campylobacter coli was analysed by cell adhesion in polystyrene plates. TC were classified as non-biofilm-forming (NBF, 1.3%), weak biofilm-forming (WBF, 68.4%), moderate biofilm-forming (MBF, 27.6%), and strong biofilm-forming (SBF, 2.7%). The inhibitory capacity of L. plantarum LP5 against TC was tested on stainless-steel, nylon, aluminium, and glass disks (treated group) and compared with biofilm-forming TC (control group). Lactiplantibacillus plantarum LP5 was inoculated, and then TC. Biofilm was removed in both experimental groups and TC and LP5 bacterial counts were performed. The L. plantarum LP5 presence reduced the formation of TC biofilm (P &lt; 0.001). The material type and strain category influenced biofilm formation, with stainless-steel and the SBF strain being the material and TC having the highest adhesion (P &lt; 0.001). Lactiplantibacillus plantarum LP5 formed a similar biofilm on all materials (P = 0.823).

Conclusions
This trial showed very promising results; L. plantarum LP5 could be incorporated as a bio-protector of TC on different surfaces.
Management of a complex cholecystocutaneous fistula with laparoscopic retrieval of gallstones embedded in the abdominal wall
Authors: Saunders Jada , Kapsampelis Panagiotis , Chouari Tarak , Nip Lawrence , Gerogiannis Ioannis N 
Published: November 2023

Abstract
Cholecystocutaneous fistula is a rare surgical entity caused by an abnormal connection between the gallbladder epithelium and the skin. These complex cases have historically required an open surgical approach and are difficult to manage. We present a rare case of a 65-year-old male patient, with chronic lithiasic cholecystitis and cholecystocutaneous fistula. The patient underwent a laparoscopic subtotal cholecystectomy, dissection of the fistula tract, and removal of the impacted stones from the abdominal wall. With appropriate expertize, a completely laparoscopic approach is acceptable and the technical challenges can be predicted and overcome through careful pre-operative planning.
Receptor-like kinases OsRLK902-1 and OsRLK902-2 form immune complexes with OsRLCK185 to regulate rice blast resistance
Authors: Liang Jiahui , Lu Ling , Zhou Houli , Fang Jianbo , Zhao Yaofei , Hou Hongna , Chen Lizhe , Cao Chang , Yang Dewei , Diao Zhijuan , Tang Dingzhong , Li Shengping 
Published: November 2023

Abstract
Receptor-like kinases (RLKs) are major regulators of the plant immune response and play important roles in the perception and transmission of immune signals. RECEPTOR LIKE KINASE 902 (RLK902) is at the key node in leucine-rich repeat receptor-like kinase interaction networks and positively regulates resistance to the bacterial pathogen Pseudomonas syringae in Arabidopsis. However, the function of RLK902 in fungal disease resistance remains obscure. In this study, we found that the expression levels of OsRLK902-1 and OsRLK902-2, encoding two orthologues of RLK902 in rice, were induced by Magnaporthe oryzae, chitin, and flg22 treatment. osrlk902-1 and osrlk902-2 knockout mutants displayed enhanced susceptibility to M. oryzae. Interestingly, the osrlk902-1 rlk902-2 double mutant exhibited similar disease susceptibility, hydrogen peroxide production, and callose deposition to the two single mutants. Further investigation showed that OsRLK902-1 interacts with and stabilizes OsRLK902-2. The two OsRLKs form a complex with OsRLCK185, a key regulator in chitin-triggered immunity, and stabilize it. Taken together, our data demonstrate that OsRLK902-1 and OsRLK902-2, as well as OsRLCK185 function together in regulating disease resistance to M. oryzae in rice.
Tmem88 plays an essential role in pharyngeal pouch progenitor specification by inhibiting Wnt/β-catenin signaling
Authors: Liu Jingwen , Yang Liping , Lu Zidong , Wang Qiang 
Published: November 2023

Abstract
Pharyngeal pouches, which are endodermal outpockets that segment the pharyngeal arches, play a crucial role in the development of craniofacial skeletons in vertebrate embryos. Our previous study successfully identified pharyngeal pouch progenitors (PPPs) in zebrafish embryos and emphasized the significance of BMP2b signaling in their specification. However, the specific mechanism by which these progenitors originate from endodermal cells remains largely unknown. Here we found that the pharmacological activation of Wnt signaling pathway disrupts the emergence of PPPs and subsequently hinders the formation of pharyngeal pouches. Moreover, we have identified the expression of tmem88a and tmem88b (collectively known as tmem88a/b) in PPPs during the early-somite stages. Furthermore, the deficiency of tmem88a/b leads to an excessive accumulation of β-catenin in both the cytoplasm and nucleus of endodermal cells that are intended to differentiate into PPPs. Importantly, suppressing the hyperactivation of Wnt/β-catenin signaling through pharmacological treatment, the defects in PPP specification in tmem88a/b−/− mutants are successfully rescued. In summary, our findings establish a clear connection between the specification of PPPs and the regulation of Wnt signaling mediated by Tmem88. These results underscore the pivotal role of Tmem88 in the development of pharyngeal pouches.
Neonatal Hyperbilirubinemia Admissions Following Clinical Practice Guideline Implementation
Authors: Smith Morgan , Ridgway Austin , Mullikin Dolores 
Published: November 2023

ABSTRACT

Introduction
Treatment of neonatal hyperbilirubinemia remains one of the most common reasons for readmission following delivery. Revised clinical practice guidelines (CPGs) for the treatment of neonatal hyperbilirubinemia were published on August 5, 2022. This report describes the preliminary outcomes following implementation of the new CPGs at Tripler Army Medical Center.

Materials and Methods
A retrospective chart review was performed for the 12 months prior to implementation and the 5 months post implementation.

Results
Bilirubin admissions decreased from 15.6% of total admissions during the 12 months prior to the new guidelines (69/441) to 4.1% of admissions (8/194) during the 5 months after implementation of the new guidelines (P &lt; 0.001). This corresponds to a 74% reduction (risk ratio = 0.26, 95% confidence interval [CI] 0.13 to 0.54). The decrease in admissions was found to correlate to greater than $140,000 in annual savings.

Conclusion
Adhering to the revised CPGs has the potential to increase resource availability at a time when nursing shortages and financial instability are impacting health care systems nationwide. No short-term adverse events were noted; however, long-term follow up will be needed.
Microbiome dynamics in rheumatic diseases
Authors: Wang Yiqing , Wang Zijun , Lu Qianjin 
Published: November 2023

Purpose of review
Rheumatic disease are characterized by their autoimmune nature, frequently affecting joints, bones, muscles, blood vessels, and connective tissues. The onset of these conditions typically unfolds gradually and subtly. It is noteworthy that individuals with rheumatic diseases often experience shifts in their microbiome, specifically on mucosal surfaces. The purpose of this review is to delve into the intricate interplay between the microbiome, encompassing bacteria, viruses and fungi, and its role in the development and aggravation of various rheumatic diseases. Additionally, it aims to offer insights into microbiome-centered therapeutic approaches for patients in the field of rheumatology.

Recent findings
The advent of next-generation sequencing has significantly improved our understanding of microbiome changes. Numerous studies have consistently revealed a strong link between rheumatism and the microbiome, especially in the oral and gut microbiota.

Summary
A deeper comprehension of the microbiome's connection to rheumatism holds potential for enhancing disease diagnosis and treatment. Targeted therapeutic approaches, including probiotics, fecal microbiota transplantation, and combination therapies with medications, offer promising avenues for disease management.
Volumization and Global Biostimulation Using Calcium Hydroxyapatite Filler: A Dual Approach for Hand Rejuvenation
Authors: Adel Noury 
Published: November 2023

Summary:
The present study was performed to evaluate the efficacy of injecting both nondiluted and diluted calcium hydroxyapatite filler into the dorsal surface of the hands in the same session, in addition to repeating the same approach along two different postoperative intervals (2 and 4 months). The study included 40 female patients who complained about the visibility of the veins and tendons, and loss of skin elasticity in their hands. First, 0.5 mL of nondiluted calcium hydroxyapatite filler was injected in each hand using a cannula through a single entry point (total of 1 mL for both hands), and the next step was injecting a diluted calcium hydroxyapatite. The same protocol was repeated at 2 and 4 months postoperative. All patients were followed up at the following intervals for recording their satisfaction score: 14 days, 2 months, 4 months, and 6 months. Postoperative measurements of the patient satisfaction score at 14 days follow-up showed a significant increase in their satisfaction; this was maintained up to 6 months postoperative. Combining both nondiluted and diluted calcium hydroxyapatite filler injections for hand rejuvenation in the same session may provide more stable results than using each formula alone or in different sessions.
Tendon Transfers to Improve Grip and Pinch in Patients with Sporadic Inclusion Body Myositis
Authors: Hua Catherine , Bhai Salman , Cheng Jonathan , Hinojosa Jose , Wilson Lynn , Lubinus Manuel , Bhashyam Abhiram R. 
Published: November 2023

Background:
Sporadic inclusion body myositis (sIBM) is a rare and slowly progressive skeletal muscle disease that can cause hand dysfunction, which is a major source of disability. Tendon transfers have been reliably used to improve function in other neuromuscular settings. Given that sIBM patients often present with flexion impairments and mostly functioning extensors, we investigated the potential opportunity for tendon transfer surgery to improve hand dysfunction in sIBM patients.

Methods:
We conducted a scoping review for studies of sIBM and tendon transfers, extracted descriptions of hand function and surgical technique, and recorded results in terms of hand function. We also conducted an institutional review board–approved survey with 470 participants to determine baseline patient-reported function and to determine participant perceptions and expectations for tendon transfer surgery to improve hand function in sIBM.

Results:
We identified three published case reports on tendon transfers in sIBM patients with subjectively improved grip and pinch strength, but standardized measures of hand function or quality-of-life were not reported. Within the surveyed cohort, half of participants reported that they would consider surgery, yet only 8% had been referred to a hand surgeon. Fifty four percent of participants reported that they would consider surgery if there would be 1–2 years of benefit after surgery. All participants who would consider surgery also had significant upper extremity disability.

Discussion:
Tendon transfer surgery has the potential to improve quality-of-life for sIBM patients, and there is significant patient interest in this approach. To objectively assess its efficacy, we propose conducting a surgical trial.
Ultra-widefield Imaging Detection Rate in Identifying Peripheral Retinal Tears in Single versus Montage of Peripheral Sweeps
Authors: Jung Jesse J. , Lim Shen Yi , Chan Xavier , Yee Yeoh Clarice Hsin , Smolyar Karina , Oribello Alexander , Dizon Anne Grace , Hoang Quan V. 
Published: November 2023

ABSTRACT

Purpose:
To compare the detection rate of orthogonal, directed peripheral steering, and auto-montaged images with ultra-widefield (UWF) imaging and the factors influencing the ability to identify retinal breaks.

Design:
Retrospective cohort study

Methods:
376 treatment-naïve eyes (349 patients) that underwent laser retinopexy for retinal breaks between 2015-2021. Pre-treatment UWF orthogonal, peripheral steering, and auto-montage were cross-referenced to scleral-depressed examination to determine whether images successfully visualized all retinal breaks. Total retinal area visualized was divided by its optic disc area (pixels) to calculate relative retinal area (RRA). Potential associations were assessed by linear regression analysis.

Results:
162 eyes (154 patients) met inclusion criteria. Orthogonal, peripheral steering, and auto-montage images showed detection rates of 47.5%, 90.7%, and 80.0% respectively. RRA increased from orthogonal versus montage by 34.7%

26.5% (mean

SD), which increased detection rate by 90.8% (p=0.006). In linear probability models, vertical meridian tears decreased probability of identification in orthogonal, peripheral steering, and auto-montage by -26.6%, -86.2% and -68.7% respectively (p-values<0.001), and horizontal meridian tears increased the probability by 62.2%, 92.9%, and 85.5% (p-values<0.001). Tears posterior to the equator in orthogonal images increased the probability (91.4%,p<0.001). Artifacts such as lids/lashes, reflection, and faceguard decreased the probability in directed peripheral steering by -28.6%, -50.0%, and -66.7% respectively, (p=0.020, p=0.049 and p=0.016).

Conclusions:
Utilizing directed peripheral steering and auto-montage increases RRA and detection rate of identifying peripheral retinal breaks. Tears in horizontal meridians or posterior to the equator increase the probability of identification. Common UWF imaging artifacts can significantly limit the probability of identifying retinal tears.