bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrapulmonary schwannoma presenting as an asymptomatic lung mass: a case report
Authors: Abbas Manzar , Fatimi Asad Saulat , Hassan Syed Imad , Aamir Faiqa Binte , Arshad Sidra , Fatimi Saulat Hasnain 
Published: December 2023

Abstract
Background
Schwannomas are solitary well-circumscribed encapsulated benign tumors that exhibit Schwann cell differentiation, and arise directly from myelinated peripheral or central nerves. Although they are usually asymptomatic and found incidentally, schwannomas can cause symptoms due to compression of nearby structures which, depending on the location, can make clinical presentations widely variable. Despite their rarity, schwannomas have been documented in a number of locations including the limbs, cerebellopontine angle, posterior mediastinum, and, far more infrequently, the lungs.

Case presentation
In this article, we report an incidental finding of an intrapulmonary schwannoma in a 59-year-old Pakistani woman who was grossly asymptomatic upon presentation to the cardiothoracic surgery clinic. An [18F]fluorodeoxyglucose positron emission tomography/computed tomography scan revealed a lobulated soft-tissue lesion measuring 23 mm × 23 mm in the lower lobe of the right lung. A computed tomography-guided core biopsy of the mass was performed, which revealed a benign spindle cell lesion based on histopathological examination and immunohistochemical staining. The mass was surgically resected via a right lower lobectomy, and subsequently confirmed to be an encapsulated neoplastic lesion composed of well-differentiated Schwann cells. There were no short- or long-term complications, morbidities, or recurrences based on 1-year follow-up.

Conclusion
This report underscores the predominantly asymptomatic nature of schwannomas and reemphasizes the efficacy of surgical resection as a safe and curative procedure for a tumor of this nature. Albeit very rare, intrapulmonary schwannomas can be considered a differential diagnosis when encountering solitary asymptomatic pulmonary nodules or masses.
Application of culturomics in fungal isolation from mangrove sediments
Authors: Li Meng , Raza Mubashar , Song Shuang , Hou Lingwei , Zhang Zhi-Feng , Gao Min , Huang Jun-En , Liu Fang , Cai Lei 
Published: December 2023

Abstract
Background
Fungi play a crucial role in ecosystems, and they have been widely considered a promising source for natural compounds that are crucial for drug discovery. Fungi have a high diversity, but about 95% of them remain unknown to science. The description rate of fungi is very low, mainly due to the inability of most fungi to grow in artificial media, which could not provide a sufficiently similar environment to their natural habitats. Moreover, many species in nature are in a state of low metabolic activity which cannot readily proliferate without proper resuscitation. Previously developed culturomics techniques are mostly designed and applicable for bacteria, with few attempts for fungal isolation because of their significantly larger cell size and hyphal growth properties.

Results
This study attempted to isolate previously uncultured and rare fungi from mangrove sediments using newly developed fungal enrichment culture method (FECM) and fungal isolation chips (FiChips). Comparison of fungal community composition at different enrichment stages showed that FECM had great influence on fungal community composition, with rare taxa increased significantly, thus improving the isolation efficiency of previously uncultured fungi. Similarly, in situ cultivation using FiChips has a significant advantage in detecting and culturing rare fungi, as compared to the conventional dilution plate method (DPM). In addition, based on morphological comparisons and phylogenetic analyses, we described and proposed 38 new ascomycetous taxa, including three new families, eight new genera, 25 new species, and two new combinations (presented in additional file 1).

Conclusions
Our study demonstrated that mangrove sediments harbor a high diversity of fungi, and our new isolation approaches (FECM and FiChips) presented a high efficiency in isolating hitherto uncultured fungi, which is potentially usable for fungal isolation in other similar environments﻿.
Microbial corrosion on underwater pottery relics with typical biological condensation disease
Authors: Zhao Meng , Zhai Yang , Zhao Jing , Zhou Wenhui , Zhao Luo , Ge Yan , Zhang Kexin , Luo Hongjie 
Published: December 2023

Abstract
Underwater pottery relics salvaged from shipwrecks are vulnerable to physical, chemical and biological corrosion. In this study, the microscopic morphology and structural composition of glazed pottery fragments excavated from the South China Sea as well as purple clay teapot samples from the Yangtze River Estuary II shipwreck were analyzed by means of optical microscopy, scanning electron microscope equipped with energy dispersive spectrometer, X-ray diffraction, X-ray photoelectron spectroscopy, Fourier infrared transform spectroscopy and photoluminescence spectroscopy. According to the research results, the corrosion products deposited on the surface of the glazed pottery fragment from the South China Sea mainly included FeOOH and MnO2, whereas those on the surface of the purple clay teapot fragment from the Yangtze River Estuary II shipwreck primarily incorporated FeS2 and FeS. According to the corrosion phenomenon, it was speculated that the underwater pottery relics were mainly corroded by different microorganisms in the underwater environment, including manganese-oxidizing bacteria, dissimilatory metal-reducing bacteria and sulfate-reducing bacteria. As the corrosion process of these cultural artifacts was described and related models were established, this study provides valuable reference for the disease removal and protection of pottery relics.
Personality-based tailored explainable recommendation for trustworthy smart learning system in the age of artificial intelligence
Authors: Takami Kyosuke , Flanagan Brendan , Dai Yiling , Ogata Hiroaki 
Published: December 2023

AbstractIn the age of artificial intelligence (AI), trust in AI systems is becoming more important. Explainable recommenders, which explain why an item is recommended, have recently been proposed in the field of learning technology to improve transparency, persuasiveness, and trustworthiness. However, the methods for generating explanations are limited and do not consider the learner’s cognitive perceptions or personality. This study draws inspiration from tailored intervention research in public health and investigates the effectiveness of personality-based tailored explanations by implementing them for the recommended quizzes in an explainable recommender system. High school students (n = 217) were clustered into three distinct profiles labeled Diligent (n = 77), Fearful (n = 72), and Agreeable (n = 68), based on the Big Five personality traits. The students were divided into a tailored intervention group (n = 106) and a control group (n = 111). In the tailored intervention group, personalized explanations for recommended quizzes were provided based on student profiles, with explanations based on quiz characteristics. In the control group, only non-personalized explanations based on quiz characteristics were provided. An 18-day A/B experiment showed that the tailored intervention group had significantly higher recommendation usage than the control group. These results suggest that personality-based tailored explanations with a recommender approach are effective for e-learning engagement and imply improved trustworthiness of AI learning systems.
Magnitude determination using cumulative absolute absement for earthquake early warning
Authors: Wu Yih-Min , Mittal Himanshu , Lin Yueh-Ho , Chang Yu-Hsuan 
Published: December 2023

AbstractThe cumulative absolute absement (CAA) of the 3 s window after P-wave arrival can be used to estimate the magnitude ($${M}_{CAA}$$MCAA) of an earthquake. This method can achieve good results even when only the six stations nearest to the epicenter are used. The standard deviation between the estimated CAA magnitude ($${M}_{CAA}$$MCAA) and the moment magnitude ($${M}_{w}$$Mw) is found to be 0.3 when using either 6 or 20 stations. This means that$${M}_{CAA}$$MCAAcan be reliably predicted using the closest 6 stations. On the other hand, the magnitude ($${M}_{Pd}$$MPd) derived from$${P}_{d}$$Pdusing the closest 20 stations has a standard deviation of 0.4 between the estimated$${M}_{Pd}$$MPdand$${M}_{w}$$Mw. This suggests that CAA is a better magnitude determination parameter for the EEW system than$${P}_{d}$$Pd.
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Authors: Jiang Meng-Yuan , Man Wan-Rong , Zhang Xue-Bin , Zhang Xiao-Hua , Duan Yu , Lin Jie , Zhang Yan , Cao Yang , Wu De-Xi , Shu Xiao-Fei , Xin Lei , Wang Hao , Zhang Xiao , Li Cong-Ye , Gu Xiao-Ming , Zhang Xuan , Sun Dong-Dong 
Published: December 2023

Abstract
Background
Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role in the pathogenesis of DCM. The aim of this study is to investigate the regulatory effect of Adipsin on DCM lipotoxicity and its molecular mechanism.

Methods
A high-fat diet (HFD)-induced type 2 diabetes mellitus model was constructed in mice with adipose tissue-specific overexpression of Adipsin (Adipsin-Tg). Liquid chromatography-tandem mass spectrometry (LC–MS/MS), glutathione-S-transferase (GST) pull-down technique, Co-immunoprecipitation (Co-IP) and immunofluorescence colocalization analyses were used to investigate the molecules which can directly interact with Adipsin. The immunocolloidal gold method was also used to detect the interaction between Adipsin and its downstream modulator.

Results
The expression of Adipsin was significantly downregulated in the HFD-induced DCM model (P < 0.05). Adipose tissue-specific overexpression of Adipsin significantly improved cardiac function and alleviated cardiac remodeling in DCM (P < 0.05). Adipsin overexpression also alleviated mitochondrial oxidative phosphorylation function in diabetic stress (P < 0.05). LC–MS/MS analysis, GST pull-down technique and Co-IP studies revealed that interleukin-1 receptor-associated kinase-like 2 (Irak2) was a downstream regulator of Adipsin. Immunofluorescence analysis also revealed that Adipsin was co-localized with Irak2 in cardiomyocytes. Immunocolloidal gold electron microscopy and Western blotting analysis indicated that Adipsin inhibited the mitochondrial translocation of Irak2 in DCM, thus dampening the interaction between Irak2 and prohibitin (Phb)-optic atrophy protein 1 (Opa1) on mitochondria and improving the structural integrity and function of mitochondria (P < 0.05). Interestingly, in the presence of Irak2 knockdown, Adipsin overexpression did not further alleviate myocardial mitochondrial destruction and cardiac dysfunction, suggesting a downstream role of Irak2 in Adipsin-induced responses (P < 0.05). Consistent with these findings, overexpression of Adipsin after Irak2 knockdown did not further reduce the accumulation of lipids and their metabolites in the cardiac myocardium, nor did it enhance the oxidation capacity of cardiomyocytes expose to palmitate (PA) (P < 0.05). These results indicated that Irak2 may be a downstream regulator of Adipsin.

Conclusions
Adipsin improves fatty acid β-oxidation and alleviates mitochondrial injury in DCM. The mechanism is related to Irak2 interaction and inhibition of Irak2 mitochondrial translocation.
Analysis of patients’ thoughts and background factors influencing attitudes toward Deprescribing: interviews to obtain hints for highly satisfying and valid prescriptions
Authors: Arai Sayaka , Ishikawa Takahiro , Arai Kenichi , Suzuki Takaaki , Ishii Itsuko 
Published: December 2023

Abstract
Background
Prescribing with high levels of medical appropriateness and patient satisfaction improves adherence. However, its appropriateness does not always match patient preference. Deprescription is important for ensuring the safety of medication therapy, but is not straightforward. Although successful deprescribing requires knowledge of patients’ thoughts on their prescriptions and factors that influence their acceptance of deprescribing, few comprehensive studies have been conducted on this topic. The aim of this study was to identify factors that influence patients’ attitudes toward deprescribing and obtain hints on how to achieve higher patient satisfaction and prescribing adequacy.

Methods
A questionnaire was administered to hospitalized patients and a logistic regression analysis was conducted to examine factors that influence their attitude toward deprescribing. Individual factors affecting patients’ thoughts and wishes regarding prescribing were extracted and analysed in detail.

Results
The analysis included 106 patients, of whom 40 (37.7%) wished deprescribing. Logistic regression analysis showed that “Age”, “Wish to reduce the number and types of medications”, “Satisfaction”, “Concerns about side effects”, and “Wish not to have certain medications changed” were factors influencing attitudes toward deprescribing. The results suggested that the factors were influenced by patients’ perceptions and individual patient backgrounds. There was a gap between willingness to reduce medication and to change their medications. Seventy-eight percent of all respondents indicated that they would like to reduce the number and type of pills they take if possible. However, only 44.6% of these patients indicated that they would actually like to change their medication.

Conclusions
This study is the only one to comprehensively investigate prescription content, patient background, and patients’ thoughts on factors influencing attitudes toward deprescribing. This study revealed five factors that can influence inclination toward deprescribing. In addition, the results suggest that patients want to be able to feel well with fewer medications if possible. This information may be useful in determining prescriptions that have high validity and patient satisfaction. Further research is needed on the gap between willingness to reduce medications and to change medications.
Pharmacokinetics of nanoparticles: current knowledge, future directions and its implications in drug delivery
Authors: Haripriyaa Muthukrishnan , Suthindhiran Krishnamurthy 
Published: December 2023

Abstract
Background
Nanoparticles have emerged as a viable biological candidate with the possibility to be employed as drug carriers. They acquire high surface-to-volume ratios and unique physicochemical features such as biochemical, magnetic, optical, and electrical changes at the cellular, atomic, and molecular levels. This phenomenon has proven extensive utility for biomedical applications, as their biological activity has fewer adverse effects than traditional medications.

Main body of the abstract
The new spectrum of nanomaterials—nanomedicines—has accomplished disease management by detecting, restoring, and regeneration of damaged tissues. Therefore, designing appropriate nanomaterial-based drug delivery systems for final clinical evaluations requires accurate knowledge of pharmacokinetic factors relevant to the LADME in order to meet the required criteria (liberation, adsorption, distribution, metabolism, and elimination). To identify and predict the in vivo reaction of nanoparticles, a deeper understanding of the link between the physicochemical properties of nanomaterials and their contact with the body is necessary. This will allow a distinguished comparison of traditional medicines and nanoparticles.

Short conclusion
This review paper attempts to analyze the basic pharmacokinetic potential of nanoparticles in depth. Therefore, profiling the pharmacokinetic analysis will enable us to review the treatment outcome to overcome their adverse properties, provide a broad overview, and deliver remarkable ways to advance the use of nanoparticles in the biomedical industry.

Graphical abstract
Lisocabtagene Maraleucel in Relapsed/Refractory Mantle Cell Lymphoma: Primary Analysis of the Mantle Cell Lymphoma Cohort From TRANSCEND NHL 001, a Phase I Multicenter Seamless Design Study
Authors: Wang Michael , Siddiqi Tanya , Gordon Leo I. , Kamdar Manali , Lunning Matthew , Hirayama Alexandre V. , Abramson Jeremy S. , Arnason Jon , Ghosh Nilanjan , Mehta Amitkumar , Andreadis Charalambos , Solomon Scott R. , Kostic Ana , Dehner Christine , Espinola Ricardo , Peng Lily , Ogasawara Ken , Chattin Amy , Eliason Laurie , Palomba M. Lia 
Published: December 2023

PURPOSE To report the primary analysis results from the mantle cell lymphoma (MCL) cohort of the phase I seamless design TRANSCEND NHL 001 (ClinicalTrials.gov identifier: NCT02631044 ) study. METHODS Patients with relapsed/refractory (R/R) MCL after ≥two lines of previous therapy, including a Bruton tyrosine kinase inhibitor (BTKi), an alkylating agent, and a CD20-targeted agent, received lisocabtagene maraleucel (liso-cel) at a target dose level (DL) of 50 × 106 (DL1) or 100 × 106 (DL2) chimeric antigen receptor-positive T cells. Primary end points were adverse events (AEs), dose-limiting toxicities, and objective response rate (ORR) by independent review committee per Lugano criteria. RESULTS Of 104 leukapheresed patients, liso-cel was infused into 88. Median (range) number of previous lines of therapy was three (1-11) with 30% receiving ≥five previous lines of therapy, 73% of patients were age 65 years and older, 69% had refractory disease, 53% had BTKi refractory disease, 23% had TP53 mutation, and 8% had secondary CNS lymphoma. Median (range) on-study follow-up was 16.1 months (0.4-60.5). In the efficacy set (n = 83; DL1 + DL2), ORR was 83.1% (95% CI, 73.3 to 90.5) and complete response (CR) rate was 72.3% (95% CI, 61.4 to 81.6). Median duration of response was 15.7 months (95% CI, 6.2 to 24.0) and progression-free survival was 15.3 months (95% CI, 6.6 to 24.9). Most common grade ≥3 treatment-emergent AEs were neutropenia (56%), anemia (37.5%), and thrombocytopenia (25%). Cytokine release syndrome (CRS) was reported in 61% of patients (grade 3/4, 1%; grade 5, 0), neurologic events (NEs) in 31% (grade 3/4, 9%; grade 5, 0), grade ≥3 infections in 15%, and prolonged cytopenia in 40%. CONCLUSION Liso-cel demonstrated high CR rate and deep, durable responses with low incidence of grade ≥3 CRS, NE, and infections in patients with heavily pretreated R/R MCL, including those with high-risk, aggressive disease.
Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda
Authors: Tusubira Andrew K. , Ssinabulya Isaac , Kalyesubula Robert , Nalwadda Christine K. , Akiteng Ann R. , Ngaruiya Christine , Rabin Tracy L. , Katahoire Anne , Armstrong-Hough Mari , Hsieh Evelyn , Hawley Nicola L. , Schwartz Jeremy I. 
Published: December 2023

Background
Implementing effective self-care practices for non-communicable diseases (NCD) prevents complications and morbidity. However, scanty evidence exists among patients in rural sub-Saharan Africa (SSA). We sought to describe and compare existing self-care practices among patients with hypertension (HTN) and diabetes (DM) in rural Uganda.

Methods
Between April and August 2019, we executed a cross-sectional investigation involving 385 adult patients diagnosed with HTN and/or DM. These participants were systematically randomly selected from three outpatient NCD clinics in the Nakaseke district. Data collection was facilitated using a structured survey that inquired about participants’ healthcare-seeking patterns, access to self-care services, education on self-care, medication compliance, and overall health-related quality of life. We utilized Chi-square tests and logistic regression analyses to discern disparities in self-care practices, education, and healthcare-seeking actions based on the patient’s conditions.

Results
Of the 385 participants, 39.2% had only DM, 36.9% had only HTN, and 23.9% had both conditions (HTN/DM). Participants with DM or both conditions reported more clinic visits in the past year than those with only HTN (P = 0.005). Similarly, most DM-only and HTN/DM participants monitored their weight monthly, unlike those with only HTN (P<0.0001). Participants with DM or HTN/DM were more frequently educated about their health condition(s), dietary habits, and weight management than those with only HTN. Specifically, education about their conditions yielded adjusted odds ratios (aOR) of 5.57 for DM-only and 4.12 for HTN/DM. Similarly, for diet, aORs were 2.77 (DM-only) and 4.21 (HTN/DM), and for weight management, aORs were 3.62 (DM-only) and 4.02 (HTN/DM). Medication adherence was notably higher in DM-only participants (aOR = 2.19). Challenges in self-care were significantly more reported by women (aOR = 2.07) and those above 65 years (aOR = 5.91), regardless of their specific condition(s).

Conclusion
Compared to rural Ugandans with HTN-only, participants with DM had greater utilization of healthcare services, exposure to self-care education, and adherence to medicine and self-monitoring behaviors. These findings should inform ongoing efforts to improve and integrate NCD service delivery in rural SSA.
Factors associated with low school readiness, a linked health and education data study in Wales, UK
Authors: Bandyopadhyay Amrita , Marchant Emily , Jones Hope , Parker Michael , Evans Julie , Brophy Sinead 
Published: December 2023

Background
School readiness is a measure of a child’s cognitive, social, and emotional readiness to begin formal schooling. Children with low school readiness need additional support from schools for learning, developing required social and academic skills, and catching-up with their school-ready peers. This study aims to identify the most significant risk factors associated with low school readiness using linked routine data for children in Wales.

Method
This was a longitudinal cohort study using linked data. The cohort comprises of children who completed the Foundation Phase assessment between 2012 and 2018. Individuals were identified by linking Welsh Demographic Service and Pre16 Education Attainment datasets. School readiness was assessed via the binary outcome of the Foundation Phase assessment (achieved/not achieved). This study used multivariable logistic regression model and a decision tree to identify and weight the most important risk factors associated with low school readiness.

Results
In order of importance, logistic regression identified maternal learning difficulties (adjusted odds ratio 5.35(95% confidence interval 3.97–7.22)), childhood epilepsy (2.95(2.39–3.66)), very low birth weight (2.24(1.86–2.70), being a boy (2.11(2.04–2.19)), being on free school meals (1.85(1.78–1.93)), living in the most deprived areas (1.67(1.57–1.77)), maternal death (1.47(1.09–1.98)), and maternal diabetes (1.46(1.23–1.78)) as factors associated with low school readiness. Using a decision tree, eligibility for free school meals, being a boy, absence/low attendance at school, being born late in the academic year, being a low birthweight child, and not being breastfed were factors which were associated with low school readiness.

Conclusion
This work suggests that public health interventions focusing on children who are: boys, living in deprived areas, have poor early years attendance, have parents with learning difficulties, have parents with an illness or have illnesses themselves, would make the most difference to school readiness in the population.