bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of the Inflammatory Profile of Blood Serum in Human Breast Cancer: Prominent Roles for TNF-alpha and RPR Pathways on Breast Surgery
Authors: Mahfuddin Ahmad Za'im Muhtar , Prajoko Yan Wisnu , Sofyan Harahap Mohamad , Rachmawati Banundari , Istanto Nurcahyo Widya 
Published: February 2025

Background: The objective of this study is to compare the effects between the combination of PECS Block II with GA and GA alone on the inflammation levels in breast cancer, measure by Tumor Necrosis Factor-Alpha (TNF-α) and the red blood cell distribution width to platelet ratio (RPR).
Methods: Experimental analytical study with parallel randomized control trial was done in 48 breast cancer patients who underwent breast removal surgery at Dr. Kariadi Hospital between August – October 2023. Patients were randomly allocated into 2 groups, control (GA only) and treatment (PECS Block II + GA). Demographic data were obtained preoperatively, blood samples were collected 24 hours before and after surgery. TNF-α levels were analyzed using enzyme-linked immunosorbant assay (ELISA), while RPR were obtained from complete blood count. Independent t and mann-whitney tests were used, with a p-value <0,05 was considered significant.
Results: Postoperative TNF-α levels were similar in both groups (8.15 ± 5.31 vs 6.21 ± 5.58; p=0,135), but the difference between TNF-α levels was significantly higher in treatment group (-5.08 ± 3.70; p = 0.001). Postoperative RPR levels were higher in control group than treatment group (0,64 ± 0,28 vs 0,50 ± 0,20; p=0,031), where the difference between RPR levels was higher in treatment group (-0,07 ± 0,19; p = 0,037).
Conclusion: Inflammatory biomarkers, in the form of TNF-α and RPR in breast cancer surgery were found to be lower with the usage of the combination of PECS Block II with general anesthesia than with general anesthesia only.
Breast Cancer after Hodgkin's Lymphoma: An Observational Study
Authors: Milardi Francesco , Michieletto Silvia , Bozza Fernando , Rigato Lisa , Saibene Tania , Cagol Matteo , Ferrucci Massimo , Passeri Daniele , Toffanin Mariacristina , Kraljic Tajna , Marchet Alberto , Evangelista Laura 
Published: February 2025

Background: Breast cancer (BC) counts for half of the excess risk of second cancer after Hodgkin Lymphoma (HL), but evidence about the clinical and pathological features of these cancers is lacking. The aim of this study was to evaluate whether these secondary BCs have distinctive characteristics compared to sporadic ones.
Methods: This is a case-control study comparing patients who developed BC after receiving treatment for HL with an age-matched cohort of non-irradiated patients. All the cases were treated at the Veneto Institute of Oncology (Padua, Italy) between 2002 and 2017. We analyzed the clinical and pathologic features of BCs and compared treatment modalities using Chi-squared tests. Kaplan-Meier survival analyses were conducted to investigate overall and disease-free survival in the two groups.
Results: 35 patients who were treated for HL and subsequently developed BCs were identified. BC occurred after a mean interval of 19.65 years (SD=10.08 years) from the HD diagnosis. 4 of the patients treated for HL (11.4%) had a bilateral presentation. 80% of the cases and 63% of the controls were ER+/HER- (p=0.516), while 20% of the HL group and 5.7% of the sporadic group were ER- /HER- (p=0.116). Ipsilateral BC recurrence (17.1% vs 8.6% in the sporadic BC group, p=0.346) and death events were more frequent in the HL group (11.4% vs 5.7% in the sporadic BC group, p=0.433), with a mean follow-up of 70 months (standard deviation=42.8months).
Conclusions: Our data show that BC arising after HL often presented with bilateral localization, aggressive biological profiles, and had high recurrence rates. Dedicated treatment modalities should be considered and evaluated in a multidisciplinary setting.
Analisis Kualitas Pelayanan pada Cafe Zona Drink terhadap Kepuasan Konsumen Ayam Geprek di Kota Ruteng
Authors: Sikone Hilarius Yosef 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui tingkat kepuasan konsumen ayam geprek berdasarkan kualitas pelayanan yang diberikan para karyawan. Penelitian ini dilaksanakan pada bulan Juli s/d Agustus 2024 di Cafe Zona Drink kota Ruteng-Manggarai. Metode yang digunakan adalah survey, dengan melakukan wawancara langsung terhadap konsumen yang datang ke lokasi penelitian menggunakan alat bantu kuisioner. Penentuan responden dilakukan dengan metode accidental sampling, yaitu metode pengambilan sampel yang dilakukan secara acak pada responden yang datang berkunjung. Metode analisis data menggunakan analisis deskriptif dan analisis uji regresi linear berganda untuk menggambarkan pengaruh kualitas pelayanan terhadap kepuasan konsumen/pelanggan. Hasil penelitian menunjukkan bahwa konsumen yang berkunjung dan menikmati menu makanan di Cafe Zona Drink Ruteng didominasi oleh pengunjung dengan tingkat umur antara 26-32 tahun (40%), berpendidikan sarjana (S1) (48%), pekerjaan sebagai PNS/TNI/Polri (52%), dan memiliki tingkat pendapatan pada kisaran Rp 1.500.000,- hingga kurang dari Rp 2.000.000,- per bulan (45%). Dari lima variabel pengukuran kualitas pelayanan yang memengaruhi tingkat kepuasan konsumen/penlanggan adalah variabel bukti fisik, variabel keandalan dan variabel perhatian yang dominan memengaruhi kepuasan konsumen/pelanggan.
Study on Serum Cholesterol in Female Type 2 Diabetes Mellitus Patients
Authors: Hussain Maria 
Published: February 2025

The relationship between diabetes and cardiovascular risk is closely linked to dyslipidaemia, a condition where there is an abnormal amount of lipids (cholesterol, triglycerides, etc.) in blood. In female diabetic patients, understanding the lipid profile is essential due to the unique physiological and hormonal differences compared to males. A cross-sectional, descriptive study was carried out in the Department of Physiology, Mymensingh Medical College, Bangladesh, between July 2016 and June 2017, to see the cholesterol levels in type 2 diabetes mellitus female patients and compare with that of normal subjects. A total of 210 subjects were selected. They were grouped as control group (group-I) consisting of 70 healthy females of reproductive age, (21-45 years) and study group (group-II), which was again subdivided to group-IIA (70 diabetic females of reproductive age, 21-45 years) and group-IIB (70 diabetic females of post-menopausal age, 45-70 years). Estimation of serum cholesterol was done by enzymatic colorimetric method. The mean serum total cholesterol in group I, group IIA and group IIB were found 171.05±12.07 mg/dl, 217.75±36.87 mg/dl 239.28±48.01 mg/dl respectively. The difference between group I and group IIA was found statistically highly significant (p<0.0001). Similarly, the difference between group IIA and group IIB was also statistically significant (p<0.05). Our data suggests that serum total cholesterol observed in control group of normal healthy females was within normal physiological range. However, in type 2 diabetic females, both in reproductive age group and postmenopausal group, serum total cholesterol levels were found elevated.
CBMJ 2025 January: Vol. 14 No. 01 P: 61-65
Patterns of Prescribed Drugs and Knowledge of Use of Drug Delivery Devices among Adult Bronchial Asthma Patients in a Tertiary Hospital in Bangladesh
Authors: Nishi Manira Khanam , Akter Sonia , Naher Halimoon , Tania Israt Jahan , Shams Nadia 
Published: February 2025

The prevalence of asthma has grown steadily over the decades in developing countries like Bangladesh. A cross-sectional, observational study was carried out in the Department of Pharmacology & Therapeutics in collaboration with the Department of Respiratory Medicine and Internal Medicine of Mymensingh Medical College Hospital, Mymensingh, Bangladesh, from July 2017 to June 2018, to explore drug prescription pattern and knowledge of use of drug delivery devices among bronchial asthma patients. A total of 160 adult patients (≥18 years) were selected non-randomly for this study. A total of 225 metered dose inhaler (MDI) were prescribed, which constituted the most common mode of administration of drugs to the asthmatic patients (48.07%), followed by oral tablet 223(47.66%) and accuhaler inhaler 20(4.27%). Out of 160 patients, 139 patients were treated with inhalation therapy. Among 139 patients, 46(33.09%) patients received an MDI with spacer; all of them knew how to use the device properly. 73(52.52%) patients received only MDI; among them, only 30(41%) patients could use the device properly. 20(14.39%) patients received accuhaler and all of them could use the device properly.
CBMJ 2025 January: Vol. 14 No. 01 P: 115-117
Epidermal Invagination with Distinctive Cornoid Lamella: A Case Study of Porokeratosis in A Middle-Aged Male
Authors: Islam Nahida , Shakil Mohammad Imdadul Hoque 
Published: February 2025

Porokeratosis is a rare keratinization disorder with specific pathologic findings involving abnormally processed epidermal keratin and presenting with the cornoid lamella. The current case report involves a 38-year-old male patient, who was communicating with a cutaneous lesion on the back of his left side, which best illustrates this condition. A 0.8x0.5x0.4 cm full-thickness skin biopsy was subjected to histopathological examination that showed an intradermal epidermal invagination with hyperkeratosis and parakeratosis. The characteristic diagnostic feature, the cornoid lamella, was described; the granular layer near the parakeratotic column was reduced. Further observations were that basal melanocytes were increased in areas immediately adjacent to the arterialized vessels and perivascular accumulation of chronic inflammatory cells in the dermis, while granulomas or malignancy were absent. The case also demonstrated the role of histopathological examination in increasing diagnostic rates and the need for the integration of various management approaches. With the risks of malignant transformation reported, primarily to squamous cell carcinoma, the concept incorporates compliance with follow-up examinations, photoprotective interventions, patient counseling, and/or adapted therapy perspectives. The case also shows multi-factorial etiology of porokeratosis through the presence of both genetic mutations of MVK and MVD and environmental factors, and immunological state. This case study adds a rare evidence along with its specific histopathological characteristics that help to define porokeratosis and direct relevant therapeutic management.
CBMJ 2025 January: Vol. 14 No. 01 P: 168-171
Generalized Anxiety in Uninvestigated Dyspepsia Patients: A Single Centre Cross-Sectional Study
Authors: Mahbub Imteaz , Karim Md Enamul , Hossain Md Altaf , Rahman Chowdhury Md Moshfiqur , Appolo Al Mahmood , Rahim Sayeda 
Published: February 2025

Introduction: Generalized anxiety is the most common mental disorder worldwide. Psychological stress like anxiety may cause gastrointestinal distress and lead to dyspeptic symptoms. Moreover, dyspepsia especially uninvestigated dyspepsia in turn may cause anxiety among the patients by creating uncertainty about the disease and its future. Objective: To measure anxiety among patients suffering from uninvestigated dyspepsia. Materials and Methods: This study was conducted at the outpatient department of Medical Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital from December 2023 to May 2024 over six months. A total of 164 patients of uninvestigated dyspepsia patients were enrolled and by dint of GAD-7 validated Bengali questionnaire their generalized anxiety level was measured and categorized. Demographic variables were analyzed by chi square test and correlation with anxiety and number of symptoms was done by Pearson correlation. P value < 0.05 was regarded as statistically significant. Results: One hundred and sixty-four patients with uninvestigated dyspepsia attending the outpatient department of Sheikh Russel National Gastroliver Institute and Hospital from December 2023 to May 2024 were enrolled. Among the patients, 92 patients were female and 72 were male without any significant difference (P = 0.06). The common age group with dyspepsia and anxiety was 18-40 years. The difference with higher age groups was significant (P =0.02). Most participants were service holders or businessman professions without significant differences (P = 0.97). There was a significant positive correlation between anxiety and an increasing number of symptoms of dyspepsia (P = 0.007, r = +.9929). Conclusion: Anxiety and dyspepsia have a positive relationship. Younger age, female sex and stressed professions like service may contribute to dyspepsia.
Medicine Today 2025, Vol.37 (1): 57-60
Educação Ambiental e as tecnologias digitais: análise das produções de teses e dissertações de 2010 até 2017
Authors: Carmo Amanda Amália Araújo do , Almeida Patrícia Vasconcelos , Sá Brenda Amaral Morais Sarmento de 
Published: February 2025

O presente artigo de revisão bibliográfica tem por objetivo observar, a partir das pesquisas, a presença das tecnologias para o ensino da Educação Ambiental (EA) e na formação de professores, no contexto da educação básica e cursos de formação para professores (pós-graduação stricto sensu). Para isso, realizamos uma pesquisa de teses e dissertações em duas bases de banco de dados que foram publicadas no período de 2010 a 2017. Para análise dos trabalhos foram criadas categorias utilizando os pressupostos da Análise de Conteúdo. As categorias encontradas foram: “Os discursos do ensino da Educação Ambiental”, “O ensino da Educação Ambiental a e Tecnologias Digitais” e “Tecnologias digitais na formação de professores na Educação Ambiental”. Constatamos que existem poucos trabalhos que a discutem a EA com a utilização das tecnologias. De maneira geral percebemos ao analisar os trabalhos que o discurso da EA perpassa pela análise crítica da realidade. Quanto o ensino da EA através das tecnologias digitais pode ser promissor desde que os professores tenham um objetivo claro e não veja as tecnologias como salvadoras do ensino.
Ekphrases, Autopsies, Diffusions: Detail in A. C. Swinburne’s Poetry
Authors: Pancrazi Andria 
Published: January 2025

The posterity of A. C. Swinburne’s body of work, be it dramatic, critical or poetic, has been fluctuating over the last 150 years, since the publication of his first works in the 1860s. One of the main points of critical discussion has been the dimension of dilution and digression of Swinburne’s poetry. Swinburnean longueurs, described as either the crowning glory or the downfall of the poet’s art, encourage us to consider the poem as a space of expansion, rather than a space for concision. Through ekphrases, blazons and autopsies, this article proposes to study the importance of detail in the endeavour of poetic diffusion undertaken by Swinburne.
Le proche et le lointain : peinture panoramique et regards londoniens à l’aube du dix-neuvième siècle
Authors: Ibata Hélène 
Published: January 2025

L’invention du panorama par Robert Barker à la fin du dix-huitième siècle témoigne d’une évolution radicale de l’appréhension de l’espace et de sa représentation, dans le contexte d’une urbanisation sans précédent. Les premières peintures panoramiques, consacrées à deux centres urbains en rapide expansion, Edimbourg et Londres, font apparaître le souci d’ordonner le flux accru de stimuli visuels qui caractérise désormais l’expérience citadine. On voit s’affirmer ce que Michel de Certeau décrit comme un désir de surplomb, et la quête d’un regard totalisant, désincarné, libéré des pratiques quotidiennes de la ville et avec elles du détail et du particulier.La présente étude examine les nouvelles attitudes spectatorielles qui se manifestent dans le panorama, en mettant l’accent sur leur ancrage intellectuel, social et politique, mais aussi en soulignant la façon dont la vue panoramique participe de la démocratisation de la sphère culturelle et de la création d’un espace public qui transcende le particulier. Elle avance que ce nouveau regard et ses tensions — notamment entre le proche et le lointain, l’unité visuelle et la fragmentation — traduisent une modernisation de la vision qu’on voit ainsi à l’œuvre dès l’aube du dix-neuvième siècle.
HUBUNGAN UNSAFE CONDITION DENGAN KECELAKAAN KERJA PADA FOUNDRY DI PT. BARATA INDONESIA (PERSERO)
Authors: Rusdiana Salvi Khilda , Pasca B Nugrahadi Dwi 
Published: February 2025

Unsafe condition (Kondisi tidak aman) mencakup berbagai faktor, seperti peralatan yang tidak layak pakai atau rusak, perlindungan dan penghalang yang tidak cukup, alat pelindung diri yang kurang memadai. Kecelakaan kerja dapat terjadi dikarenakan perilaku tidak aman dan kondisi lingkungan yang tidak aman. Kebaruan pada penelitian ini membahas dari faktor perawatan mesin, pengamanan pada mesin (safety guard) yang berpengaruh terhadap kejadian kecelakaan kerja. Penelitian ini bertujuan untuk menganalisis hubungan Unsafe condition dengan kecelakaan kerja pada foundry PT. Barata Indonesia (Persero). Metode penelitian yaitu kuantitatif dengan desain cross-sectional menggunakan pendekatan observasional analitik. Populasi dari penelitian ini seluruh karyawan pada foundry tahun 2023 sebanyak 126 orang. Jumlah sampel penelitian sebanyak 96 responden diambil dengan simple random sampling. Instrumen yang digunakan adalah kuesioner Unsafe condition dan riwayat kecelakaan kerja dan lembar observasi untuk suhu, kebisingan dan pencahayaan. Analisis dengan chi-square. Hasil penelitian yaitu terdapat hubungan Unsafe condition dengan kecelakaan kerja pada foundry PT. Barata Indonesia (Persero) dengan hasil uji chi-square p = 0,009 0,05. Kesimpulannya bahwa pada area Foundry PT. Barata Indonesia (Persero) Gresik tingkat Unsafe condition memiliki tinggi sebagian besar (58,3%) yang dikarenakan peralatan yang belum terawat secara konsisten, faktor pencahayaan dan suhu yang belum sesuai standar yang ditentukan dapat memicu terjadinya kecelakaan kerja.
Explicabilidade e contraditório algorítimico nas decisões automatizadas no setor público: as decisões em processos apoiados em algoritmos e o problema da redução da realidade a dados
Authors: Tavares André Afonso , Bitencourt Caroline Müller , Cristóvam José  Sérgio Da Silva' 
Published: January 2025

Diante da produção cada vez mais crescente de decisões automatizadas, sejam intermediárias ou finais, durante processos administrativos ou judiciais, o presente trabalho tem enquanto problema de pesquisa: de que forma as decisões automatizadas, em observância ao princípio da publicidade, estão sendo explicadas, isto é, tem sua lógica de programação tornada pública e transparente? Além disso, em razão da necessidade de se respeitar o princípio do contraditório, uma vez que essas decisões automatizadas podem afetar direitos ou ocasionar obrigações, de que forma se tem garantido aos interessados o direito de influenciar o resultado do processamento algorítmico? O objetivo geral consiste em investigar de que forma as decisões automatizados no âmbito de processos administrativos e judiciais que se apoiam em algoritmos têm buscado oferecer explicabilidade em respeito ao princípio da publicidade, bem como de qual maneira tem sido oportunizado ao interesse a possibilidade de influenciar no resultado do processamento automatizado algorítmico dessas decisões, em respeito ao princípio do contraditório. A pesquisa adota o método dedutivo e enquanto técnicas de pesquisa será utilizada de consulta à legislação e à literatura científica, bem como à documentação indireta, especialmente, registros e informações relacionados a casos de utilização de algoritmos para produção de decisões automatizadas no âmbito de processos administrativos e judiciais setor público apoiados em algoritmos. As conclusões desse trabalho demonstram a distinção entre algoritmo simples e algoritmo de Inteligência Artificial; as diferentes tipologias de decisões nos processos digitais: decisão humana, decisão híbrida e decisão algorítmica; o dever de explicabilidade quanto ao momento: prévia (ex ante), concomitante e posterior (ex post); e, por fim, a existência do dever de garantia ao contraditório algorítmico na legislação brasileira no âmbito de processos administrativos e judiciais apoiados em algoritmos.
Perbandingan Modal Sosial Anggota di Dua Kelompok Tani (Studi Kasus Kelompok Tani Teratai Merah dan Kelompok Tani Teratai Putih)
Authors: Hasan Juhan Mahdum , Ibrahim Jabal Tarik , Tain Anas 
Published: January 2025

Modal sosial memiliki peranan penting dalam mencapai tujuan kelompok tani. Setiap anggota kelompok tani memiliki modal sosial berbeda, meskipun kelompok tani berada dalam satu wilayah yang sama. Penelitian ini bertujuan untuk menganalisis perbandingan modal sosial anggota Kelompok Tani Teratai Merah dan Kelompok Tani Teratai Putih di Desa Cinandang, Kecamatan Dawarblandong, Kabupaten Mojokerto dan untuk menganalisis hubungan modal sosial dengan kelas kelompok tani. Metode penelitian menggunakan metode kuantitatif. Pengambilan sampel dilakukan melalui pendekatan stratified random sampling. Data yang digunakan adalah data hasil wawancara dengan 40 orang anggota Kelompok Tani Teratai Merah dan 27 anggota Kelompok Tani Teratai Putih. Teknik analisis yang digunakan adalah uji mann-whitney dan software yang digunakan adalah IBM SPSS Statistics 22. Berdasarkan hasil penelitian terdapat perbedaan modal sosial (kepercayaan, norma sosial, jaringan dan partisipasi) anggota Kelompok Tani Teratai Merah dan Kelompok Tani Teratai Putih. Perbedaan anggota Kelompok Tani Teratai Merah dan Kelompok Teratai Putih karena skor indikator kepercayaan, norma sosial, jaringan dan partisipasi anggota kelompok tani berbeda . Pada uji korelasi modal sosial menunjukkan adanya hubungan antara modal sosial dengan kelas kelompok tani.
Pembimbingan dan Analisis Kesulitan Membaca pada Siswa Kelas III dan IV SDN PUTRA PANJALU dengan Strategi Service Learning untuk Peningkatan Kemampuan Membaca siswa
Authors: Mia Rasmiaty  , Ilma Nurmisa  , Riska Al Anisa  , Samsul Hidayat  , Annisa Farida  , Muhammad Ihsana  , Iwan Satriyo Nugroho  
Published: February 2025

Pengabdian kepada masyarakat ini bertujuan untuk menganalisis dan memberikan pembimbingan dalam penanganan kesulitan membaca yang dialami oleh kelas 3 dan 4 SDN Panjalu. Pengabdian kepada masyarakat ini menggunakan Metode Service Learning dengan mengintegrasikan pembelajaran ke dalam kegiatan pengabdian masyarakat atau Kemitraan Universitas–Masyarakat (KUM). Pengabdian berbasis penelitian menggunakan metode deskriptif kualitatif dengan pendekatan studi kasus. Hasil pengabdian kepada masyarakat menunjukkan bahwa siswa kelas III dan IV di SDN Putra Panjalu menghadapi beragam tantangan dalam kemampuan membaca, terutama terkait pengenalan huruf, pengejaan, serta pembacaan huruf konsonan, vokal, diftong, dan suku kata. Faktor penyebab adalah minimnya dukungan orang tua, lingkungan yang kurang mendukung, serta rendahnya minat siswa untuk belajar. Hasil pengabdian yang berdampak kepada masyarakat adalah peningkatan kemampuan membaca siswa, keberhasilan dalam identifikasi masalah membaca, meningkatnya kesadaran guru, peningkatan dukungan orang tua, pengembangan bahan ajar membaca, serta peningkatan kesadaran masyarakat.