bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing staff and supervisors perceptions on stress and resilience: a qualitative study
Authors: Helaß Madeleine , Greinacher Anja , Genrich Melanie , Müller Andreas , Angerer Peter , Gündel Harald , Junne Florian , Nikendei Christoph , Maatouk Imad 
Published: January 2025

Abstract

Background
Supervisor–subordinate relationship is high relevant in dealing with work-related stress and providing a compassionate, high-quality, and safe nursing care while meeting the needs of the hospital. Our aim was to assess the predisposing risk and resilience factors of the stress of nursing staff as well as to explore the common and distinctive perceptions of these factors between nurses without a managerial position (nursing staff) and employees in a supervising position (nurse managers, ward nurses).

Design
Generic qualitative study using half-standardized interviews.

Methods
Fifty nurses and supervisors from different departments from a German hospital of maximum medical care participated in this study between August and November 2018. Nineteen face-to-face interviews and five focus groups were conducted. Transcripts were subjected to structured qualitative content analysis.

Results
Systematised in Lazarus’s transactional model, nurses, and supervisors mentioned similar risk and resilience factors of stress. Disagreement in suggested responsibility for nurses’ stress or health and an evaluation of implemented measures meeting the nurses’ needs are discussed.

Conclusion
Nursing staff and supervisors should enforce exchange to reduce disagreements in perceptions and to improve mutual understanding. Furthermore, measures to meet nurses’ needs to minimize stress and to improve collaboration and job satisfaction should be developed in close coordination with the target group. The focus should be placed on restructuring training and education programs with supplementation of self-responsibility promotion.

Trail registration
The study was registered with the German Register for Clinical Studies (DRKS 00013482) on 09 March 2018.
Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease
Authors: Xue Jing , Nian Miaomiao , Liang Yangyang , Zhu Zeqin , Hu Zhenyu , Jia Yuanyuan , Chi Shuhong , Chen Juan 
Published: January 2025

Abstract

Background
Neutrophil extracellular trap (NET) formation has been implicated as a pathogenic mechanism in both rheumatoid arthritis (RA) and interstitial lung disease (ILD). However, the role of NETs in RA-associated ILD (RA-ILD) and the mechanisms driving NET formation remain unclear. This study aimed to assess the involvement of NETs in RA-ILD and elucidate the underlying mechanisms.

Methods
Single-cell sequencing was used to identify changes in the quantity and function of neutrophils in the lung tissue of a zymosan A (ZYM)-induced interstitial pneumonia arthritis model. Additionally, nuclear receptor 4A3 (NR4A3) interference was performed in HL-60 cells to assess its impact on NET formation and the transformation of MRC-5 cells into myofibroblasts. The clinical relevance of plasma myeloperoxidase-DNA (MPO-DNA), citrullinated histone 3 (Cit-H3), and cell-free DNA was evaluated in RA-ILD patients with different imaging types via a commercial enzyme-linked immunosorbent assay (ELISA).

Results
In the ZYM-treated SKG mouse model, which recapitulates key features of RA-ILD, an increased population of neutrophils in the lung tissue was primarily responsible for NET formation. Mechanistically, we found that interference with NR4A3 expression enhanced NET formation in HL-60 cells, which in turn promoted the differentiation of MRC-5 cells into myofibroblasts. Clinically, plasma MPO-DNA levels are elevated in patients with RA-nonspecific interstitial pneumonia (RA-NSIP), whereas Cit-H3 levels are elevated in RA-usual interstitial pneumonia (RA-UIP) patients compared with healthy subjects. ROC curve analysis further revealed that the combination of plasma MPO-DNA, rheumatoid factor (RF), and anti-citrullinated protein (anti-CCP) and the combination of Cit-H3, RF, and anti-CCP were superior diagnostic panels for NSIP and UIP in RA-ILD patients, respectively. Moreover, compared with those from healthy controls, neutrophils from patients with RA-UIP and RA-NSIP demonstrated a significantly increased ability to form NETs and induce the differentiation of MRC-5 cells into myofibroblasts. Specifically, RA-UIP patients exhibited a greater capacity for NET formation and the differentiation of MRC-5 cells into myofibroblasts than did RA-NSIP patients.

Conclusions
These findings suggest that targeting NETs may be a novel therapeutic approach for treating ILD in RA patients.
Estimating mortality attributable to alcohol or tobacco – a cohort study from Germany
Authors: John Ulrich , Rumpf Hans-Jürgen , Hanke Monika , Meyer Christian 
Published: January 2025

Abstract

Background
Little is known about mortality from four disorder combinations: fully attributable to alcohol or tobacco, partly attributable to both alcohol and tobacco, to tobacco only, to alcohol only.

Aim
To analyze whether residents who had disclosed risky alcohol drinking or daily tobacco smoking had a shorter time to death than non-risky drinkers and never daily smokers twenty years later according to the disorder combinations.

Methods
A random adult general population sample (4,075 study participants) of a northern German area had been interviewed in the years 1996–1997. Vital status and death certificate data were gathered 2017–2018. The data analysis included estimates of alcohol- or tobacco-attributable mortality using all conditions given in the death certificate and alternatively the underlying cause of death only.

Results
Among 573 deaths, 71.9–94.1% had any alcohol- or tobacco-attributable disorder depending on the estimate. Risky alcohol consumption and daily tobacco smoking at baseline were related to disorders in the death certificate according to the combinations. Deaths with an alcohol- and tobacco-attributable disorder were related to risky alcohol consumption (subhazard ratio 1.57; 95% confidence interval 1.25–1.98) and to daily tobacco smoking at baseline (subhazard ratio 1.85; 95% confidence interval 1.42–2.41).

Conclusion
First, more than 70% of the deceased persons had one or more alcohol- or tobacco-attributable disorders. This finding suggests that total mortality seems to be the suitable outcome if potential effects of alcohol or tobacco consumption in a general population are to be estimated. Second, the relations of risky alcohol consumption and tobacco smoking with time to death speak in favor of the validity of alcohol- and of tobacco-attributable disorders in death certificates and of considering both alcohol consumption and tobacco smoking if attributable deaths are to be estimated.
Diagnostic delay in cerebral creatine deficiency disorders: lessons learned from a cross-sectional single center study, and guanidinoacetate and creatine measurements in Switzerland between 2015 and 2023
Authors: Kaufman Christina , D’Andrea Anaïs , Hackenberg Annette , Poms Martin , Braissant Olivier , Häberle Johannes 
Published: January 2025

Abstract

Background
Cerebral creatine deficiency disorders (CCDD) are rare diseases caused by defects in the enzymes L-arginine: glycine amidinotransferase (AGAT) or guanidinoacetate-N-methyltransferase (GAMT), which are involved in synthesis of creatine; or by a defect in the creatine transporter (CRTR), which is essential for uptake of creatine as important energy source into the target cells. Patients with CCDD can present with a variety of unspecific symptoms: global developmental delay, speech-language disorder, behavioral abnormalities and seizures. Early treatment initiation is essential in AGAT and GAMT deficiencies to achieve a favorable outcome. This study describes the CCDD patient cohort in a single center, and an analysis of the referrals to two Swiss laboratories in Lausanne and Zurich between 2015 and 2023 for the two marker metabolites guanidinoacetate and creatine.

Results
The patient cohort comprised 6 patients (defects: 2 GAMT, 4 CRTR), who were initially seen by different subspecialties depending on first symptoms. There was a diagnostic and therapeutic delay between 3 and 32 months (mean 13.8). Numbers of biomarker requests showed a constant increase during the study period, with a majority of tests performed in urine, the preferred sample for CCDD detection. Almost all samples (93.3%) were sent in by large hospitals (mainly from neurology, developmental pediatrics and metabolism) and only few (5.2%) by pediatricians in private practice, although those usually see the patients first.

Conclusions
The data from this study demonstrate a relevant delay in identifying patients with these rare conditions, and a predominance of biomarker analysis requested from pediatric subspecialties that are involved in patient management often long after occurrence of symptoms. To reduce the diagnostic delay and the outcome of patients, the current practice of sample referral should be reflected and first-contact healthcare providers should be encouraged to initiate selective screening.
Ferroelectric capacitive memories: devices, arrays, and applications
Authors: Zhou Zuopu , Jiao Leming , Zheng Zijie , Chen Yue , Han Kaizhen , Kang Yuye , Zhang Dong , Wang Xiaolin , Kong Qiwen , Sun Chen , Xie Jiawei , Gong Xiao 
Published: January 2025

Abstract
Ferroelectric capacitive memories (FCMs) utilize ferroelectric polarization to modulate device capacitance for data storage, providing a new technological pathway to achieve two-terminal non-destructive-read ferroelectric memory. In contrast to the conventional resistive memories, the unique capacitive operation mechanism of FCMs transfers the memory reading and in-memory computing to charge domain, offering ultra-high energy efficiency, better compatibility to large-scale array, and negligible read disturbance. In recent years, extensive research has been conducted on FCMs. Various device designs were proposed and experimentally demonstrated with progressively enhanced performance, showing remarkable potential of the novel technology. This article summarizes several typical FCM devices by introducing their mechanisms, comparing their performance, and discussing their limitations. We further investigate the capacitive crossbar array operation and review the recent progress in the FCM integration and array-level demonstrations. In addition, we present the computing-in-memory applications of the FCMs to realize ultra-low-power machine learning acceleration for future computing systems.
Diurnal and daily fluctuations in levels of the urinary oxidative stress marker 8-hydroxyguanosine in spot urine samples
Authors: Li Yun-Shan , Fujisawa Koichi , Kawai Kazuaki 
Published: January 2025

Abstract

Background
Urinary 8-hydroxyguanosine (8-OHGuo) levels serve as a biomarker for oxidative stress and hydroxyl radical–induced RNA damage. Evaluating the diurnal and daily fluctuations in urinary 8-OHGuo excretion levels is essential for understanding its implications. However, research in this area remains limited. In this study, we aim to investigate the diurnal and daily fluctuations in 8-OHGuo levels as well as the factors that influence these variations, using spot urine samples.

Methods
Urine samples were collected from seven healthy participants during each urination from the time of awakening until 24:00 h to evaluate diurnal variations. To assess daily fluctuations, urine samples were collected from 18 healthy participants at the time of awakening for 23 consecutive days. The urinary 8-OHGuo levels were measured using an HPLC-ECD method.

Results
No significant variations were observed in the diurnal levels of urinary 8-OHGuo among non-smokers. Conversely, the daily variation of 8-OHGuo in the urine of the smoker was significant, with a coefficient of variation of 18.71%. Each individual maintained a characteristic value despite some diurnal fluctuations. Furthermore, the daily levels of 8-OHGuo exhibited a range of variations influenced by lifestyle factors, including mental state, sleep duration, smoking, menstrual cycle, and dietary habits.

Conclusion
As a specific marker of RNA oxidation, 8-OHGuo provides unique insights distinct from those provided by the widely used DNA oxidation marker 8-hydroxydeoxyguanosine as an indicator of oxidative stress. Urinary 8-OHGuo could serve as a valuable biomarker for managing and preventing oxidative stress–related diseases, provided that the specific range of daily variations is established. The high daily variation in urinary 8-OHGuo levels necessitates the use of multiple samples to accurately determine individual levels. However, further research with large sample sizes will help to validate these findings.
Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients
Authors: Abdelsalam Ramy A. , El-Shawaf Ibrahim M. , Abdel-Aziz Azza , Bismar Tarek A. , Yussif Shaimaa M. 
Published: January 2025

Abstract

Background
Wnt/β-catenin pathway has an important role in hepatocarcinogenesis. It has been involved in progression, growth, epithelial mesenchymal transition and metastasis of hepatocellular carcinoma (HCC). This pathway may represent a potential target for evolving treatment strategies. β-catenin gene (CTNNB1) has been identified as an important oncogene involved in hepatocarcinogenesis in previous trials to understand the pathogenesis of HCC. This study aimed to spot light on the role of Wnt/ β-Catenin and CTNNB1 gene mutation in HCC development and its relation with different clinicopathological features.

Patients and methods
This study was conducted on 121 HCC cases that were obtained from liver explants from pathology laboratory at Mansoura Gastroenterology center retrospectively in the period between 2006-2017. Tissue Microarray (TMAs) were prepared. β-Catenin and Wnt immunohistochemical (IHC) staining was performed on these blocks. Detection and scoring of CTNNB1 gene mutation were done by Chromogenic In Situ Hybridization (CISH). The relation between aberrant β-Catenin, Wnt2 IHC staining and CTNNB1 mRNA expression and different clinicopathological characteristics was studied.

Results
A significant association was detected between aberrent β-catenin IHC staining and larger tumor size (p = 0.011), multiple tumor nodules (p = 0.021), higher stages of the tumor (p = 0.03) and with presence of lymphovascular emboli (LVE) (p = 0.034). However, no significant association was detected with tumor site, presence of lymph node spread, distant metastasis, tumor necrosis, local recurrence and alpha-fetoprotein level. No significant association was seen between Wnt2 IHC staining with either tumor site, tumor size, number of tumor nodules, presence of LVE, tumor necrosis, tumor grade, TNM stage or presence of local recurrence. A significant association was seen between CTNNB1 mRNA expression and larger tumor size (> 5 cm) (p = 0.041), higher tumor stages (Stages III and IV) (p = 0.005) and presence of distant metastasis (p = 0.008).). No significant association between CTNNB1 mRNA expression and LVE, tumor necrosis, tumor grade or occurrance of local recurrence.

Conclusion
Aberrant β-catenin IHC staining and CTNNB1 gene mutation in HCC correlate significantly with tumor size, number of tumor nodules, tumor stage and presence of LVE. All of these items confer poor prognosis in HCC. A highly significant correlation was detected between CTNNB1 gene mutation and aberrant β-catenin expression in HCC cases.
“The First Duty of Charity”
Authors: Fallas Amy 
Published: January 2025

Abstract
From its conceptualization during the late nineteenth century to its grand opening in 1927 and through subsequent decades, the Coptic Hospital has been a fixture in the geographies and genealogies of sectarianism in Cairo. When Boutros Ghali Pasha established the Great Coptic Benevolent Society with other Coptic laity in 1881, he and the board of directors envisioned medical care for the Coptic poor as the organization's first and primary duty. When they faced a myriad of challenges in erecting the hospital, they pivoted to a broader purview of the society's mandate by expanding service to all Egyptians regardless of religious affiliation amid the most polemical sectarian encounters and debates of the early twentieth century. They mediated these tensions by employing a language of sectarian neutrality and claiming to contribute to Egypt's march toward “civilization” through the establishment of the country's first Egyptian-established and -operated private hospital. Yet many aspects of the hospital's development—from appointing department directors to tracking patients—continued to center religious identity as a salient category of medical management. This article examines the discursive and material trajectories of the Coptic Hospital through the prism of medical philanthropy and sectarian infrastructures in modern Cairo.
Religion and Its Publics in South Asia
Authors: Chopra Rohit , Sundaram Dheepa 
Published: January 2025

Abstract
This introduction to the special section of the issue outlines the genesis of the section, provides a brief history of publics and counterpublics in South Asian contexts, and highlights key themes and questions that the section covers. It discusses its contributions, how they trouble the concept of the South Asian public, and the new vistas of inquiry that the section invites. It also presents a survey of relevant literature on South Asian publics to situate the special section in the context of existing scholarly work on religion and publics as well as the specific affordances and aspects that shape how we understand the concept of the public within South Asian spaces. The introduction also describes each article in the section and concludes with a discussion what the special section may tell us about the possible futures of religion and its publics in South Asia, the value and scope of theorizing publics within South Asia, and future areas of inquiry that could prove productive in building on the themes, issues, and concerns raised here.
Determinants of circular migration patterns to Badung regency
Authors: Pebrian I Kadek Rio Dwi , Mustika Made Dwi Setyadhi 
Published: January 2025

The influence of migration causes the growth of the population in a region. Migration occurs due to imbalances in development, especially in the economic sector. Whereby people migrate to obtain employment due to high wages and job opportunities in the destination area. This research analyzes the factors influencing the population's decision to engage in circular migration to Badung Regency. The analytical tool used is logistic regression analysis, specifically Binary Logistic Regression. The sample consists of 123 respondents. The research results indicate that variables such as wage levels, number of family dependents, gender, activities in the area of origin, distance, age, and squared age collectively and significantly influence the decision of the population to engage in circular migration to Badung Regency. Partially, the research results show that the number of family dependents, gender, activities in the area of origin, and age significantly positively affect the decision of the population to engage in circular migration to Badung Regency. Meanwhile, wage levels, distance, and squared age significantly negatively affect the population's decision to engage in circular migration to Badung Regency.
Promiscuous, diseased and unfit: Discourses and embodiments of Indian indentured women across the British Empire, c. 1840–1920
Authors: Wright Morag Flora 
Published: January 2025

Abstract
Indian women represented something of a persistent problem for colonial officials. The Indian Government consistently emphasized the importance of obtaining high numbers of indentured women, as the lack of women on plantations was portrayed as leading to so-called vice and ‘immoral’ sexual relations. For the plantation colonies, women represented the social reproduction of the workforce, through their domestic and reproductive labour. I chart three imperial discourses which attempted to embody indentured women in markedly different ways: as promiscuous wives, as diseased and as possessors of unfit wombs. Through these embodiments I explore how the increasing violences and failures of the indenture system interacted with nineteenth-century understandings of race to map these problems not onto the system of indenture but onto the bodies of indentured women. I look at how a particularly medicalized language around women created by colonial officials sought to control, border and embody the concept of the woman worker as inherently racially deficient. In doing so the colonial states involved in indentured labour positioned themselves as father, as correctors of racial deviancy and indenture as a system, by extension, as a means of stepping into subjecthood, history and civility.
Ghostly (re)visions: Embodying the Indian Caribbean churile
Authors: Ballengee Christopher L. 
Published: January 2025

Abstract
In Indian Caribbean folklore, a churile is the spirit of a woman who has died while pregnant or during childbirth. She is a ‘jumbie’ in limbo between the natural and supernatural realms. This article traces the migration of churile folklore from South Asia to the Caribbean and examines its relevance in Indian Caribbean culture today. I highlight how embodiments and evocations of the churile have been reinterpreted to navigate intergenerational trauma and reimagine Indian Caribbean femininity. Using four key examples — Vanessa Godden’s performance film Churile (2016), Sabiyha Rasheed’s song ‘Choorile’ (2020), Kevin Jared Hosein’s short story ‘Maiden of the Mud’ (2016) and Ryan Persadie’s drag persona Tifa Wine in his ongoing Coolieween project — I discuss how the churile becomes a potent symbol for confronting the legacies of indenture. These works transform the horrifying symbolism of the churile, using her to address historical and personal wounds, while expressing resilience and reclaiming agency, underscoring the enduring relevance of embodied experiences in shaping complex identities.
Indentured impressions: The embodied materiality of artistic practices in Mauritius
Authors: Ghosh Baishali 
Published: January 2025

Abstract
This article ponders the ways contemporary Mauritius art negotiates the lives and afterlives of indentured labour histories and how artists explore visual, textual and sensorial materials to connect and counter their indentured ancestors’ narratives. The article aims to contribute to the epistemological and methodological scope of studying underrepresented visual and sensorial materials of indentured labour histories. It also reflects upon a decade-long engagement with Mauritian artists who are descendants of indentured labourers and who were involved in building a new identity following the independence of Mauritius in 1968. The first part of the text discusses how the artists appropriate colonial records, familial objects and sensorial evidences in executing their works and articulating their methods; it argues that the artistic praxes deliberately process embodied indentured labour histories. The second part thinks with and through a collaborative mural installed in the Renganaden Seeneevassen Building, a hub of government and corporate enterprises in Mauritius. It discusses how the mural can be understood as a critique of the stigmatization of the indentured labourers’ bodies and how it subverts the colonial gaze that tried to frame and limit indentured bodies. Reading the mural becomes a way to unravel colonial forms of spectatorship, and instead focus on how the artists voice their subaltern indentured ancestors and coeval communities.