bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery
Authors: Mehta Parth , Shende Pravin 
Published: November 2023

AbstractOpsonization plays a pivotal role in hindering controlled drug release from nanoformulations due to macrophage‐mediated nanoparticle destruction. While first and second‐generation delivery systems, such as lipoplexes (50–150 nm) and quantum dots, hold immense potential in revolutionizing disease treatment through spatiotemporal controlled drug delivery, their therapeutic efficacy is restricted by the selective labeling of nanoparticles for uptake by reticuloendothelial system and mononuclear phagocyte system via various molecular forces, such as electrostatic, hydrophobic, and van der Waals bonds. This review article presents novel insights into surface‐modification techniques utilizing macromolecule‐mediated approaches, including PEGylation, di‐block copolymerization, and multi‐block polymerization. These techniques induce stealth properties by generating steric forces to repel micromolecular‐opsonins, such as fibrinogen, thereby mitigating opsonization effects. Moreover, advanced biological methods, like cellular hitchhiking and dysopsonic protein adsorption, are highlighted for their potential to induce biological camouflage by adsorbing onto the nanoparticulate surface, leading to immune escape. These significant findings pave the way for the development of long‐circulating next‐generation nanoplatforms capable of delivering superior therapy to patients. Future integration of artificial intelligence‐based algorithms, integrated with nanoparticle properties such as shape, size, and surface chemistry, can aid in elucidating nanoparticulate‐surface morphology and predicting interactions with the immune system, providing valuable insights into the probable path of opsonization.
Investigation Of The Biosynthesis Pathway That Generates cis‐Jasmone
Authors: Inoue Shiro , Tsuzuki Hiromu , Matsuda Kazuhiko , Kitaoka Naoki , Matsuura Hideyuki 
Published: November 2023

AbstractResearchers have established that (+)‐7‐iso‐jasmonic acid ((+)‐7‐iso‐JA) is an intermediate in the production of cis‐jasmone (CJ); however, the biosynthetic pathway of CJ has not been fully described. Previous reports stated that CJ, a substructure of pyrethrin II produced by pyrethrum (Tanacetum cinerariifolium), is not biosynthesized through this biosynthetic pathway. To clarify the ambiguity, stable isotope‐labelled jasmonates were synthesized, and compounds were applied to apple mint (Mentha suaveolens) via air propagation. The results showed that cis‐jasmone is not generated from intermediate (+)‐7‐iso‐JA, and (+)‐7‐iso‐JA is not produced from 3,7‐dideydro‐JA (3,7‐ddh‐JA); however, 3,7‐didehydro‐JA and 4,5‐didehydro‐7‐iso‐JA were converted into CJ and JA, respectively.
Chimeric Small Molecules for Detouring Drugs into Mitochondria to Engender Apoptosis in Cancer Cells
Authors: Mishra Tripti , Gautam Abhinav , Ingle Jaypalsing , Basu Sudipta 
Published: November 2023

AbstractMitochondrion has appeared as one of the important targets for anti‐cancer therapy. Subsequently, small molecule anti‐cancer drugs are directed to the mitochondria for improved therapeutic efficacy. However, simultaneous imaging and impairing mitochondria by a single probe remained a major challenge. To address this, herein Chimeric Small Molecules (CSMs) encompassing drugs, fluorophore and mitochondria homing moiety were designed and synthesized through a concise strategy. Screening of the CSMs in a panel of cancer cell lines (HeLa, MCF7, A549, and HCT‐116) revealed that one of the CSMs comprising Indomethacin V exhibited remarkable cervical cancer cell (HeLa) killing (IC50=0.97 μM). This lead CSM homed into the mitochondria of HeLa cells within 1 h followed by mitochondrial damage and reactive oxygen species (ROS) generation. This novel Indomethacin V‐based CSM‐mediated mitochondrial damage induced programmed cell death (apoptosis). We anticipate these CSMs can be used as tools to understand the drug effects in organelle chemical biology in diseased states.
Physicochemical characteristics and popping efficiencies of popping beans from different breeding programs and grow‐out locations
Authors: Rezaey Mahvash , Heitholt Jim , Miles Carol , Ganjyal Girish M. 
Published: November 2023

AbstractBackground and ObjectivesPopping beans are genotypes developed from crosses between nuña beans and common beans adapted to temperate climates. Toasted popping beans are a potential snack with a nutty flavor and malted milk ball‐like texture. Except for moisture content, the influence of other factors of raw beans on their popping efficiency has remained understudied. Thus, this study aimed to evaluate the proximate composition, functional properties, and their impact on the popping efficiency of 20 popping bean samples from different lines, harvest seasons, and locations.FindingsResults showed significant differences (p < .05) in physicochemical characteristics and functional properties among the samples, including differences in starch, protein, fiber, fat, moisture, and ash content. The water absorption index, the water solubility index, and flour swelling power also significantly differed between samples. The highest popping efficiency was 98.3%, while the lowest popping efficiency was 24.0%, with no significant correlation between physicochemical characteristics and popping efficiency. However, the study did find a correlation between pericarp color and popping percentage.ConclusionThere was no significant correlation between physicochemical characteristics and popping efficiency in popping beans.
Physicochemical properties of buckwheat flours and their influence on focaccia bread quality
Authors: Nalbandian Elizabeth , Karkle Elisa , Ganjyal Girish M. 
Published: November 2023

AbstractBackground and ObjectivesThe effects of buckwheat/wheat flour blends on bread production were investigated. Focaccia bread was prepared with 25%, 50%, and 75% substitution rates of whole (WBK) and dehulled buckwheat flour (DBK) with refined wheat bread flour. The physicochemical properties of the flours, their dough properties, and focaccia quality were studied.FindingsThe flours showed differences in protein content; the WBK was high in fiber, while the DBK was composed mainly of starch. The peak time in the mixograph increased, and the height at peak time decreased as the buckwheat substitution rate increased. Gluten dilution partially explains these results. The specific volume of the focaccia decreased with 50% and 75% substitution rates of WBF, possibly attributable to fiber particles limiting the expansion of gas cells in the bread. The number of such cells, measured by the C‐cell, increased and cell diameters decreased as the buckwheat substitution levels increased. These trends were also evident in the decrease in bread density.ConclusionsFocaccia, with 25% WBK and 25% and 50% DBK, had acceptable quality attributes comparable to those of the control.Significance and NoveltyThis research furthers understanding of the functional behavior of buckwheat flour in baked products.
Additively custom‐made 3D‐printed subperiosteal implants for the rehabilitation of the severely atrophic maxilla (a case report)
Authors: Arshad Mahnaz , Khoramshahi Nourin , Shirani Gholamreza 
Published: November 2023

Key Clinical MessageSubperiosteal implants might be the future first‐line treatment in patients with compromised alveolar ridges, although the use of proper techniques and pre‐surgical imaging is required to ensure treatment success.AbstractSevere bone loss puts the success of endosseous implants at risk. This technical report aims to introduce the subperiosteal implants (SPIs) created through additive manufacturing. A case study is presented, outlining the process and strategies employed to fully restore a maxillary structure using a customized subperiosteal implant. The patient, who had previously faced disappointment with traditional endosseous implants, received a customized SPI. A detailed 3‐year follow‐up is also provided. The design of the subperiosteal framework and abutments is based on digital records of the patient's jaw structure and a radiographic stent during occlusion. This ensures optimal placement within the dental arch. The implant and abutments are then three‐dimensional (3D) printed using a titanium alloy, while a provisional denture is 3D‐printed using polymer materials. SPIs offer a viable alternative for individuals with severe jaw bone degeneration, as demonstrated in this report detailing their application in complete maxillary restoration. This patient‐specific, prosthesis‐driven approach avoids the need for bone grafting and enables immediate functional recovery through a single surgical procedure.
Impact of the Electrochemically Inert Furan Ring on the Oxidation of the Alcohol and Aldehyde Functional Group of 5‐Hydroxymethylfurfural (HMF)
Authors: Sobota Lennart , Bondue Christoph J. , Hosseini Pouya , Kaiser Christoph , Spallek Marius , Tschulik Kristina 
Published: November 2023

AbstractThe electrochemical oxidation of bio‐based 5‐hydroxymethylfurfural (HMF) results in 2,5‐furandicarboxylic acid (FDCA), which is a renewable and environmentally friendly alternative to terephthalic acid. Using a gold electrode, we compare the electrochemical oxidation of the aldehyde and alcohol functionality in HMF to the isolated functionalities represented by ethanol and acetaldehyde. Thereby, we investigate the effect of the inert furan ring on the electrochemical reaction. The linear sweep voltammogram (LSV) of HMF in a weakly adsorbing electrolyte differs only marginally from the superposition of LSVs obtained in ethanol and acetaldehyde containing electrolytes. However, in the presence of strong adsorbates, only the kinetics of ethanol and acetaldehyde oxidation but not of HMF oxidation are hampered. We assign this to a stronger adsorption of HMF through the furan ring than through the alcohol and carbonyl functionality of ethanol and acetaldehyde. Hence, HMF is better equipped to compete for adsorption sites than aliphatic compounds.
Pretreatment Process Before Heat Pyrolysis of Plant‐based Precursors Paving Way for Fabricating High‐Performance Hard Carbon for Sodium‐Ion Batteries
Authors: Zhang Tianyun , Zhang Tian , Wang Fujuan , Ran Fen 
Published: November 2023

AbstractThe increasing demand for sodium‐ion batteries has risen due to sodium resources that are inexpensive and abundant compared with its counterpart of lithium‐ion batteries. Development of anode materials with high performance is central issue for sodium‐ion batteries. Plant‐based hard carbon material is a promising anode material for sodium ion batteries due to its green preparation process, favorable ions transport channel, and special porous structure. Previous studies have not systematically correlated the material's inherent structure limitation with its electrochemical properties, resulting in a complex classification and a lack selection of pretreatment methods. In this review, the intrinsic limitations in the structure of plant‐based precursors are divided into four parts, including impure components, single chemical structure, uncontrollable crystalline texture, and irregular porous structure. The previous pretreatment methods are reclassified, including purification component aiming at plant‐based precursors, optimized structure, and precabornized process aiming at intermediate products. Furthermore, the pretreatment strategies are discussed according to the preferred structures of plant‐based hard carbon and the relationship between structure and performance is systematically expounded. This review provides deep understanding of the mechanism of pretreatment and a guide for selecting appropriate pretreatment strategies to optimize the structure of plant‐based hard carbon for sodium ion batteries.
Ultrathin Metal–Organic Framework Nanosheets for Selective Photocatalytic C2H2 Semihydrogenation in Aqueous Solution
Authors: Dai Haojie , Zhang Ruolan , Liu Zhengyao , Jiang Wenfeng , Zhou Yongfeng 
Published: November 2023

AbstractThe selective semihydrogenation of C2H2 to C2H4 in crude C2H4 (with ~1 vol % C2H2 contamination) is a crucial process in the manufacture of polyethylene. Comparing to conventional thermalcatalytic route with Pd as catalyst under high temperature with H2 as hydrogen source, photocatalytic C2H2 reduction reaction with H2O as hydrogen source can achieve high selectivity under milder conditions, but has rarely been reported. Here, we present a kind of ultrathin metal–organic framework nanosheets (Cu‐Co‐MNSs) that demonstrate excellent catalytic activities in the semihydrogenation of C2H2. Employing Ru(bpy)32+ as the photosensitizer, this catalyst attains a noteworthy turnover number (TON) of 2124 for C2H4, coupled with an impressive selectivity of 99.5 % after 12 h visible light irradiation. This performance is comparable to molecular catalysts and notably surpasses the efficiency of bulk metal–organic framework materials. Furthermore, Cu‐Co‐MNSs achieve a 99.95 % conversion of C2H2 under industrial relevant conditions (1.10 % C2H2 in C2H4) with 90.3 % selectivity for C2H4 over C2H6, demonstrating a great potential for polymer‐grade C2H4 production.
Gd3TeBO9: A Rare‐Earth Borate with Significant Magnetocaloric Effect
Authors: Zhou Changqing , Li Rukang 
Published: November 2023

AbstractMagnetic refrigeration technology based on Gd‐based paramagnets is expected to be applied to refrigeration in extremely low temperatures, thereby reducing the consumption of liquid helium. Here, we obtained a compound, Gd3TeBO9 with high Gd3+ concentration through element substitution. The Gd3+ concentration in this compound is as high as 2.4×1024 ions/kg, which is 33 % higher than the commercial Gd3Ga5O12 (GGG), and further magnetic tests show that Gd3TeBO9 has a large magnetic entropy change (57.44 J/(kg K) and 408 mJ/(cm3 K) at 2.6 K and 7 T), which is 1.5 times that of GGG, implying the possibility of its further development as an potential magnetocaloric material.
Efficacy and feasibility of vein of Marshall ethanol infusion during persistent atrial fibrillation ablation: A systematic review and meta‐analysis
Authors: Ge Wei‐Li , Li Tao , Lu Yi‐Fei , Jiang Jian‐Jun , Tung Tao‐Hsin , Yan Su‐Hua 
Published: November 2023

AbstractBackgroundCatheter ablation (CA) is currently used to treat persistent atrial fibrillation (PeAF). However, its effectiveness is limited. This study aimed to estimate the effectiveness of the vein of Marshall absolute ethanol injection (VOM‐EI) for PeAF ablation.HypothesisAdjunctive vein of Marshall ethanol injection (VOM‐EI) strategies are more effective than conventional catheter ablation (CA) and have similar safety outcomes.MethodsWe extensively searched the literature for studies evaluating the effectiveness and safety of VOM‐EI + CA compared with CA alone. The primary endpoint was the rate of acute bidirectional block of the isthmus of the mitral annulus (MIBB). The secondary endpoints were atrial fibrillation (AF) or atrial tachycardia (AT) recurrence over 30 seconds after a 3‐month blanking period. Weighted pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs) were calculated using a random effects model.ResultsBased on the selection criteria, nine studies were included in this systematic review, including patients with AF (n = 2508), persistent AF (n = 1829), perimitral flutter (n = 103), and perimitral AT (n = 165). There were 1028 patients in the VOM‐EI + CA group and 1605 in the CA alone group. The VOM‐EI + CA group showed a lower rate of AF/AT relapse (RR = 0.70; 95% CI = 0.53–0.91; p = .008) and a higher rate of acute MIBB (RR = 1.29; 95% CI = 1.11–1.50; p = .0007) than the CA alone group.ConclusionOur meta‐analysis revealed that adjunctive VOM‐EI strategies are more effective than conventional CA and have similar safety outcomes.
Characterization and LDL‐C management in a cohort of high and very high cardiovascular risk patients: The PORTRAIT‐DYS study
Authors: Gavina Cristina , Seabra‐Carvalho Daniel , Aguiar Carlos , Anastassopoulou Anastassia , Teixeira Carla , Ruivo Jorge A. , Almeida Élia , Luz‐Duarte Leonor , Corte‐Real Ana , Canelas‐Pais Mariana , Taveira‐Gomes Tiago 
Published: November 2023

AbstractAimThis study aims to characterize sociodemographic and clinical characteristics, use of lipid‐lowering therapies (LLTs), and low‐density lipoprotein cholesterol (LDL‐C) control in a population with increased cardiovascular (CV) risk.MethodsA cross‐sectional observational study that uses electronic health records of patients from one hospital and across 14 primary care health centers in the North of Portugal, spanning from 2000 to 2020 (index date). Patients presented at least (i) 1 year of clinical data before inclusion, (ii) one primary care appointment 3 years before the index date, and (iii) sufficient data for CV risk classification. Patients were divided into three cohorts: high CV risk; atherosclerotic cardiovascular disease (ASCVD) risk equivalents without established ASCVD; evidence of ASCVD. CV risk and LDL‐C control were defined by the 2019 and 2016 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidemia guidelines.ResultsA total of 51 609 patients were included, with 23 457 patients classified as high CV risk, 19 864 with ASCVD equivalents, and 8288 with evidence of ASCVD. LDL‐C control with 2016 ESC/EAS guidelines was 32%, 10%, and 18% for each group, respectively. Considering the ESC/EAS 2019 guidelines control level was even lower: 7%, 3%, and 7% for the same cohorts, respectively. Patients without any LLT prescribed ranged from 37% in the high CV risk group to 15% in patients with evidence of ASCVD.ConclusionWe found that LDL‐C control was very low in patients at higher risk of CV events. An alarming gap between guidelines on dyslipidemia management and clinical implementation persists, even in those at very high risk or with established ASCVD.
Pre‐and post‐HSCT use of TKI therapy for fusion‐driven B‐ALL: A case series of five pediatric, adolescent and young adult patients
Authors: Shumock Savannah S. , Temple William C. , Marinoff Amanda , Aaronson Kathryn , Southworth Erica , Xirenayi Simayijiang , Lee Alex G. , Leung Stanley G. , Sweet‐Cordero E. Alejandro , Hermiston Michelle , Higham Christine , Stieglitz Elliot 
Published: November 2023

AbstractBackgroundThe development of tyrosine kinase inhibitors (TKIs) has significantly improved survival rates among patients with Philadelphia chromosome (Ph+) B cell acute lymphoblastic leukemia (B‐ALL). Ph‐like B‐ALL patients lack the BCR::ABL1 translocation but share gene expression profiles with Ph+ B‐ALL. The role of TKIs for Ph‐like patients pre‐ and post‐hematopoietic stem cell transplantation (HSCT) is not yet clear.CaseHere we present five cases of pediatric, adolescent, and young adult patients who presented with Ph‐like B‐ALL or CML in B‐ALL blast phase who were treated with personalized TKI regimens pre‐ and post‐HSCT.ConclusionThis report describes several novel Ph‐like fusions as well as combinations of TKIs with chemotherapy or immunotherapy not yet reported in the pediatric population. This case series provides real‐world experience highlighting the potential application of pre‐ and post‐HSCT use of TKIs in a subset of patients with targetable fusions.
Nickel‐Tin Nanoalloy Supported ZnO Catalysts from Mixed‐Metal Zeolitic Imidazolate Frameworks for Selective Conversion of Glycerol to 1,2‐Propanediol
Authors: Nimbalkar Ajaysing S. , Oh Kyung‐Ryul , Han Seung Ju , Yun Gwang‐Nam , Cha Seung Hyeok , Upare Pravin P. , Awad Ali , Hwang Dong Won , Hwang Young Kyu 
Published: November 2023

AbstractThe successful synthesis of finely tuned Ni1.5Sn nanoalloy phases containing ZnO catalyst with a small particle size (6.7 nm) from a mixed‐metal zeolitic imidazolate framework (MM‐ZIF) is investigated. The catalyst was evaluated for the efficient production of 1,2‐propanediol (1,2‐PDO) from crude glycerol and comprehensively characterized using several analytical techniques. Among the catalysts, 3Ni1Sn/ZnO (Ni/Sn=3/1) showed the best catalytic performance and produced the highest yield (94.2 %) of 1,2‐PDO at ~100 % conversion of glycerol; it also showed low apparent activation energy (15.4 kJ/mol) and excellent stability. The results demonstrated that the synergy between Ni−Sn alloy, finely dispersed Ni metallic sites, and the Lewis acidity of SnOx species‐loaded ZnO played a pivotal role in the high activity and selectivity of the catalyst. The confirmation of acetol intermediate and theoretical calculations verify the Ni1.5Sn phases provide the least energetic pathway for the formation of 1,2‐PDO selectively. The reusability of solvent for successive ZIF synthesis, along with the excellent recyclability of the ZIF‐derived catalyst, enables an overall sustainable process. We believe that the present synthetic protocol that uses MM‐ZIF for the conversion of various biomass‐derived platform chemicals into valuable products can be applied to various nanoalloy preparations.
Decoupled and compensated space vector pulse width modulation algorithm for dual‐channel PMSM with unbalanced power supplies
Authors: Yu Feng , Wang Zinuo , Wang Yao , Zhou Chenhui 
Published: November 2023

SummaryThis paper investigates an improved space vector pulse width modulation (SVPWM) and channel‐decoupled method for dual‐channel permanent magnet synchronous machine (PMSM) powered by unbalanced battery packs. Recently, individual power supplied voltage source inverter (VSI) is introduced considering insufficient power rating and unsafe driving in electrical vehicles (EVs). However, the issues of strong coupling and unbalanced power supplies exist between channels. Firstly, a modular topology is constructed to improve the reliability and security of the system. Secondly, the channel‐decoupled method is introduced based on multi‐dq rather than the conventional vector space decomposition (VSD) to eliminate coupling among multi‐channel. Thereafter, the variable distribution of voltage vectors (VVs) is corrected by the proposed SVPWM, where the switch can be operated appropriately. Finally, the comparative experiments are carried out focusing on decoupling and unbalanced power supplies, and the results present superior performance in terms of low torque fluctuation and balanced channel currents.