bluuebunny/crossref_metadata_2025_split huggingface dataset:
Issues of methodology, standardization and metabolite recognition for 25-hydroxyvitamin D when comparing the DiaSorin radioimmunoassay and the Nichols Advantage automated chemiluminescence protein-binding assay in hip fracture cases
Authors: Glendenning Paul , Noble Jane M , Taranto Mario , Musk Alexander A , McGuiness Marjory , Goldswain Peter R , Fraser William D , Vasikaran Samuel D 
Published: September 2003

Background: Deficiency of vitamin D is commonly associated with hip fracture and treatment with vitamin D reduces hip fracture rates. Consequently, the demand for assays to measure 25-hydroxyvitamin D (25-OHD) has increased. The Nichols Advantage chemiluminescence protein-binding assay (CLPBA) for 25-OHD is a first-generation automated immunoassay with decreased turnaround time, reduced manual handling and non-radioactive label. Methods: We compared the CLPBA to the DiaSorin radioimmunoassay (RIA) and high-performance liquid chromatography (HPLC) for the measurement of 25-OHD using 161 samples from hip fracture patients and samples before and after institution of ergocalciferol (vitamin D2) therapy. Results: A negative bias for the CLPBA at concentrations below 30 nmol/L and a positive bias at 25-OHD values above 30 nmol/L compared with the RIA resulted in diagnostic discordance for one in three samples when using 30 and 50 nmol/L as decision limits. HPLC analysis confirmed the presence of a negative bias for the CLPBA at low values. Both immunoassays under-estimate 25-hydroxyvitamin D2. Conclusions: The discordance between 25-OHD values may be due to differences in standardization of each assay relative to HPLC. Our results emphasize the need for assay-specific clinical decision limits.
Capillary blood gas analysis in complex regional pain syndrome: a pilot study
Authors: Tan ECTH , de Keijzer MH , Goris RJA 
Published: September 2003

Background: The pathophysiology of complex regional pain syndrome type 1 (CRPS 1) is still a matter of debate. An inflammatory reaction may cause the syndrome. Increasing evidence points to a role for impairment of oxygen metabolism in the affected limb. Methods: In this pilot study (16 patients) we performed capillary blood gas analysis in extremities with acute CRPS 1, in order to assess oxygen saturation and lactate concentrations. Comparison was made with the unaffected limb for capillary blood pH, pO2, SaO2, and lactate and glucose concentrations. Results: No statistically significant differences could be found. Conclusions: Capillary blood gas analysis is not useful to detect changes in oxygen saturation and lactate concentrations in CRPS 1.
Superhydrophobic and Highly Elastic Strain‐Sensing Fiber Embedded with Carbon Nanotubes and Aerogels Based on the Dipping and Drying Method
Authors: Seo Keumyoung , Jeong Sang‐Mi , Seo Hee Sung , Yang Jonguk , Ju Sanghyun , Lim Taekyung 
Published: January 2024

AbstractFor a fiber‐based strain sensor to be used as a wearable device, its conductivity and sensing characteristics should be stably maintained even during repeated mechanical movements. Additionally, the sensing characteristics should remain unaffected by external contaminants, such as water or sweat, as the sensor is expected to be in contact with the human body. In this study, a superhydrophobic and highly elastic strain‐sensing fiber with durability against continuous tension and contraction while maintaining a stable sensing performance even when in contact with water and sweat is developed. A carbon nanotube is embedded, which is a highly conductive material, inside a spandex fiber with high elasticity and shape recovery rate, enabling the stable measurement of repetitive joint movements under various strain conditions. Furthermore, a superhydrophobic silica aerogel is embedded inside the spandex fiber to facilitate stable sensing without malfunction even when exposed to external contaminants. The proposed strain‐sensing fiber can monitor joints of the human body during various movements, such as dumbbell pressing, squatting, walking, and running. Therefore, the study findings can contribute to the development of wearable healthcare devices that warrant reliable sensing.
Bioresorbable Resistive Switching Device Based on Organic/Inorganic Hybrid Structure for Transient Memory Applications
Authors: Nguyen Tan Hoang Vu , Shaikh Mohammad Tauquir Alam Shamim , Jeon Ho Jung , Vu Thi Thanh Huong , Prasad Chowdam Venkata , Labed Madani , Kim Sangmo , Rim You Seung 
Published: January 2024

AbstractBiocompatible and biodegradable resistive random‐access memory devices using Mg/agarose/Al2O3/Mg‐based organic/inorganic structures are reported, showing nonvolatile bipolar resistive switching memory behavior. The organic/inorganic‐based hybrid active layer has large working windows (≈106) and is highly stable up to 200 continuous sweeps. The device can be also tuned into multilevel memory by varying the compliance current from a few microamperes to several milliamperes. The formation of metallic filaments inside the active layer during SET and RESET stages using an X‐ray photoelectron spectroscopy depth profile and magnesium (Mg) metallic ions that penetrate the agarose layer is confirmed. For the bioresorbable test in both deionized water and phosphate‐buffered saline solution, the erasing time of whole devices can be adjusted by using an ultrathin ALD‐grown Al2O3 film.
CYCLOIDEA paralogs function partially redundantly to specify dorsal flower development in Mimulus lewisii
Authors: Dunivant Taryn S. , Singh Vibhuti , Livingston Kaylee E. , Ross Jack D. , Hileman Lena C. 
Published: January 2024

AbstractPremiseDuplicated genes (paralogs) are abundant in plant genomes, and their retention may influence the function of genetic programs and contribute to evolutionary novelty. How gene duplication affects genetic modules and what forces contribute to paralog retention are outstanding questions. The CYCLOIDEA(CYC)‐dependent flower symmetry program is a model for understanding the evolution of gene duplication, providing multiple examples of paralog partitioning and novelty. However, a novel CYC gene lineage duplication event near the origin of higher core Lamiales (HCL) has received little attention.MethodsTo understand the evolutionary fate of duplicated HCL CYC2 genes, we determined the effects on flower symmetry by suppressing MlCYC2A and MlCYC2B expression using RNA interference (RNAi). We determined the phenotypic effects on flower symmetry in single‐ and double‐silenced backgrounds and coupled our functional analyses with expression surveys of MlCYC2A, MlCYC2B, and a putative downstream RADIALIS (MlRAD5) ortholog.ResultsMlCYC2A and MlCYC2B jointly contribute to bilateral flower symmetry. MlCYC2B exhibits a clear dorsal flower identity function and may additionally function in carpel development. MlCYC2A functions in establishing dorsal petal shape. Further, our results suggest an MlCYC2A–MlCYC2B regulatory interaction, which may affect pathway homeostasis.ConclusionsOur results suggest that CYC paralogs specific to higher core Lamiales may be selectively retained for their joint contribution to bilateral flower symmetry, similar to the independently derived CYC paralogs in the Lamiales model for bilateral flower symmetry research, Antirrhinum majus (snapdragon).
Synthesis Of Dipyrrolobenzo[1,2‐a : 2′,1′‐c][1,4]diazepine Scaffold Via Three‐Component Reaction
Authors: Zinoveva Anna D. , Borisova Tatiana N. , Podchufarova Valeria A. , Novikov Anton P. , Romanycheva Anna A. , Shetnev Anton A. , Titov Alexander A. , Varlamov Alexey V. , Voskressensky Leonid G. 
Published: January 2024

AbstractA three component reaction employing readily available starting materials: 2‐(1‐pyrrolyl)benzylamine, arylglyoxal monohydrates and electron‐deficient alkenes in the synthesis of dipyrrolobenzo[1,2‐a : 2′,1′‐c][1,4]diazepines ‐ previously undescribed system and indolo[2,1‐c]pyrrolo[1,2‐a][1,4]benzodiazepine derivatives have been shown. Domino reactions of pyrrolo[1,2‐a][1,4]benzodiazepines with electron‐deficient alkenes has been proposed as another approach. The applicability of the three‐component reaction for the synthesis of indolizino[8,7‐b]indole derivatives from tryptamine has been studied. The in vitro biological activity of title compounds has been tested.
Effect of home‐based resistance training on chemotherapy relative dose intensity and tolerability in colon cancer: The FORCE randomized control trial
Authors: Caan Bette J. , Brown Justin C. , Lee Catherine , Binder Alexandra M. , Weltzien Erin , Ross Michelle C. , Quesenberry Charles P. , Campbell Kristin L. , Cespedes Feliciano Elizabeth M. , Castillo Adrienne , Quinney Sara , Yang Shengping , Meyerhardt Jeffrey A. , Schmitz Kathryn H. 
Published: January 2024

AbstractBackgroundMany patients with colon cancer cannot fully adhere to postoperative chemotherapy due to dose‐limiting toxicities, resulting in lower relative dose intensity (RDI) and potentially compromising overall survival. This study examined whether home‐based resistance training (RT) during adjuvant chemotherapy improves RDI and patient‐reported toxicities versus usual care (UC) in colon cancer patients.MethodsMulticenter, randomized control trial (RCT) conducted at community and academic practices. Enrollment of patients receiving postoperative chemotherapy for colon cancer occurred between February 23, 2018, and September 29, 2021; final follow‐up was March 21, 2022. Participants were randomized to RT (n = 90) or UC (n = 91) for the duration of chemotherapy. Participants in the RT group engaged in twice weekly home‐based progressive RT. At the end of the study, UC was given an online exercise program.ResultsAmong 181 randomized patients (mean age, 55.2 [SD, 12.8] years, 95 [52.5%] were men), there were no differences in the mean RDI among those in RT (79% [SD, 19%]) and those in UC (82% [SD, 19%]); (mean difference –0.04 [95% confidence interval (CI), –0.09 to 0.02]). Assignment to RT did not significantly reduce the number of moderate/severe symptoms per week across follow‐up (relative rate: 0.94 [95% CI, 0.72–1.22]). Additionally, time since randomization did not significantly modify the effect of RT on the overall number of symptoms (p = .06).ConclusionsAmong patients with colon cancer, these results do not support home‐based RT as an adjunct to chemotherapy specifically to improve planned treatment intensity.
Squirrel Henry Gas Solubility Optimization driven Deep Maxout Network with multi‐texture feature descriptors for digital image forgery detection
Authors: Nirmala Priya G. , Suresh Kumar K. , Suganthi N. , Muppidi Satish 
Published: January 2024

SummaryThe ability to detect image forgeries is a crucial component in solving many problems, especially social ones that arise in legal proceedings, on Facebook, and so forth. Generally, forgery detection attempts to predict the artifacts through evaluating the differences in texture properties of an image. One division of an image is copied in a comparable image, typically at a different position, in a process known as copy move forgery. The two main types of copy move forgery prediction are keypoint‐based and block‐based techniques. While the block‐based approach takes more time, the keypoint‐based model performs poorly. The goal of this research was to develop a method for detecting image counterfeiting called the Squirrel Henry Gas Solubility Optimization algorithm‐based Deep Maxout Network (SHGSO‐based DMN). Here, Steerable Pyramid Transform (SPT) decomposition is done in order to obtain quantity of multi‐scale and multi‐oriented sub bands. For the purpose of detecting forgeries, the Deep Maxout Network which was constructed using the SHGSO model is deployed. With accuracy of 0.9507, True Negative Rate (TNR) of 0.9568, and True Positive Rate (TPR) of 0.9517, the new method outperformed other current forgery detection techniques.
Performance analysis of a bridgeless power factor correction (PFC) buck–boost LED driver with ripple diversion scheme for extended lifespan
Authors: Ashok Kumar Kanithi , Narasimharaju Beeramangalla Lakshminarasaiah 
Published: January 2024

SummaryIn the state of the art of AC‐fed light‐emitting diode (LED) drivers, power factor correction (PFC), second harmonic LED current ripple elimination, low current total harmonic distortion (iTHD), removal of electrolytic capacitors (EC) and flicker‐free operation are the major challenging issues. This paper proposes a bridgeless universal voltagerange AC‐fed LED driver that overcome the major issues of LED driver. The bridgeless buck–boost PFC configuration minimizes the losses relative to the front‐end bridge rectifier‐based configurations. Operating in discontinuous conduction mode (DCM), the source current tracks the input voltage shape for a wide operating range, achieves inherent PFC and maintains low input current THD. Also, this provides significant reduction in the output current ripple with the ripple diversion circuit (RDC) connected in shunt across the LED load, which relatively reduces and utilizes low value of output capacitance. Hence, a flicker‐free operation is achieved without the use of electrolytic capacitors. In addition, the elimination of ECs improves the operating lifespan of the proposed LED driver. A detailed theoretical analysis and results of the proposed LED driver are validated on DSP and analog controller platforms with a 62 W/62 V experimental laboratory prototype. The experimental results confirm that the proposed LED driver achieves a power factor of 0.94–0.997, input current THD of maximum 6.8%, output current ripple of 5%, and a peak efficiency of 91.25% for the wide range of input voltage variation. These indices also satisfy IEC‐61000‐3‐2 and IEEE 1789‐2015 standard limits.
Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials
Authors: Di Xingpeng , Chen Jiawei , Li Ya , Wang Menghua , Wei Jingwen , Li Tianyue , Liao Banghua , Luo Deyi 
Published: January 2024

AbstractBackgroundThe impact of fibroblasts on the immune system provides insight into the function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes interact with immunocytes by secreting growth factors, cytokines, and chemokines, leading to wound healing, fibrosis, and escape of cancer immune surveillance. However, the specific mechanisms involved in the fibroblast‐immunocyte interaction network have not yet been fully elucidated.Main body and conclusionTherefore, we systematically reviewed the molecular mechanisms of fibroblast‐immunocyte interactions in fibrosis, from the history of cellular evolution and cell subtype divisions to the regulatory networks between fibroblasts and immunocytes. We also discuss how these communications function in different tissue and organ statuses, as well as potential therapies targeting the reciprocal fibroblast‐immunocyte interplay in fibrosis. A comprehensive understanding of these functional cells under pathophysiological conditions and the mechanisms by which they communicate may lead to the development of effective and specific therapies targeting fibrosis.
Universal dynamic fitting of magnetic resonance spectroscopy
Authors: Clarke William T. , Ligneul Clémence , Cottaar Michiel , Ip I. Betina , Jbabdi Saad 
Published: January 2024

AbstractPurposeDynamic (2D) MRS is a collection of techniques where acquisitions of spectra are repeated under varying experimental or physiological conditions. Dynamic MRS comprises a rich set of contrasts, including diffusion‐weighted, relaxation‐weighted, functional, edited, or hyperpolarized spectroscopy, leading to quantitative insights into multiple physiological or microstructural processes. Conventional approaches to dynamic MRS analysis ignore the shared information between spectra, and instead proceed by independently fitting noisy individual spectra before modeling temporal changes in the parameters. Here, we propose a universal dynamic MRS toolbox which allows simultaneous fitting of dynamic spectra of arbitrary type.MethodsA simple user‐interface allows information to be shared and precisely modeled across spectra to make inferences on both spectral and dynamic processes. We demonstrate and thoroughly evaluate our approach in three types of dynamic MRS techniques. Simulations of functional and edited MRS are used to demonstrate the advantages of dynamic fitting.ResultsAnalysis of synthetic functional 1H‐MRS data shows a marked decrease in parameter uncertainty as predicted by prior work. Analysis with our tool replicates the results of two previously published studies using the original in vivo functional and diffusion‐weighted data. Finally, joint spectral fitting with diffusion orientation models is demonstrated in synthetic data.ConclusionA toolbox for generalized and universal fitting of dynamic, interrelated MR spectra has been released and validated. The toolbox is shared as a fully open‐source software with comprehensive documentation, example data, and tutorials.
Assessment of the possibility of quantitative identification of the Mannesmann effect using ductile fracture criteria
Authors: Bulzak Tomasz , Wójcik Łukasz , Lis Konrad , Kusiak Tomasz 
Published: January 2024

AbstractThis article presents a study to estimate the possibility of determining the shape and size of a Mannesmann effect crack using the finite element method. Experimental tests were carried out to obtain reference specimens with a crack. A rotational compression test of cylindrical specimens in a channel was used for the experimental studies. Finite element tests were carried out using nine ductile fracture criteria. In the first stage of the study, using the rotational compression test and the finite element method, the limit values of the fracture criteria were determined. In the second stage, the development of a Mannesmann effect crack was simulated using the limit values of the fracture criteria using the finite element method. Based on the analysis, it was found that the greatest agreement in terms of void shape and size obtained in finite element method and experiment was obtained for the Ayada criterion. Analysis of the progression of the shape of the void formed using the Ayada criterion showed that crack initiation occurs as a result of maximum principal stress. The development of the resulting void is the result of the action of the maximum shear stress as well as the maximum principal stress.
Adsorption studies of toxic organic pesticides from aqueous medium by sodium alginate‐cl‐poly (allyl amine‐co‐acrylic acid)/copper oxide nanocomposite hydrogel: Isotherms, kinetics, and thermodynamics
Authors: Samanta Santu Kumar , Adak Shubhadeep , Tripathy Tridib 
Published: January 2024

AbstractThe sodium alginate (SAG) cross‐linked poly (allyl amine‐co‐acrylic acid)/copper oxide [SAG‐cl‐poly(AAM‐co‐AA)/CuO] nanocomposite hydrogel (SNCHG) was synthesized by using a free radical initiated cross‐linked copolymerization process in‐situ. Several characterization techniques namely FTIR, PXRD, FESEM with EDAX, TGA, and BET analysis were employed to characterize the synthesized SNCHG. Water swelling properties together with swelling kinetics of SNCHG were evaluated. The highest swelling (35% after 30 minutes) was found at pH 8. The adsorption property of the developed nanocomposite hydrogel (SNCHG) was evaluated in three pesticides' solution namely chlorpyrifos (CP), phosalone (PL), and 4,4'‐ dichloro diphenyl dichloro ethane (DD) in water medium. Several factors affecting the adsorption like solution pH, time of adsorption, amount of pesticides, etc. were evaluated. The maximum adsorption were found to be 96.9% for CP at pH 7, 95.85% for PL at pH 7, and 86.72% for DD at pH 4. Pseudo‐second order kinetics and both Freundlich and Dubinin–Radushkevich adsorption isotherms were followed in all the three cases. Maximum adsorption capacity (Qm) were found to be 507.61, 158.22, and 132.97 mg g−1 for CP, PL, and DD, respectively. The adsorption process was endothermic in nature and spontaneous.Highlights
A novel CuO Nps embedded sodium alginate‐based hydrogel is developed.
Increment of surface area and water swelling property are illustrated.
The hydrogel exhibits excellent adsorption property towards pesticides.
The observed affinity of adsorption is chemisorption.
Polysulfide Anions [Sx]2− (x = 2, 3, 4, 5): Promising Functional Building Units for Infrared Nonlinear Optical Materials
Authors: Song Miao , Xiao Yan , Yang Daqing , Wang Ying , Zhang Bingbing 
Published: January 2024

AbstractInfrared nonlinear optical (IR NLO) materials play significant roles in laser technology. The novel functional building units (FBUs) are of great importance in constructing NLO materials with strong second harmonic generation (SHG). Herein, polysulfide anion [Sx]2− (x = 2, 3, 4, 5) units are investigated on NLO‐related properties and structure‐performance relationships. Theoretical calculations uncover that the [Sx]2− (x = 2, 3, 4, 5) units are potential IR NLO FBUs with large polarizability anisotropy (δ), hyperpolarizability (β) and wide HOMO–LUMO gap. Fourteen crystals including [Sx]2− (x = 2, 3, 4, 5) units are calculated and analyzed. The results show that these units can result in a wide IR transmittance range, significant SHG effects, wide band gap Eg (Na2S4: Eg = 3.09 eV), and large birefringence Δn [BaS3 (P21212): Δn = 0.70]. More importantly, it is highlighted that the crystal materials including with [Sx]2− (x = 2, 3, 4, 5) groups are good candidates for the exploration of the outstanding IR NLO materials.
A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption
Authors: Liang Ke , Nan Fuchun , Wang Jian , Zhang Yunxiu , Li Jian , Xue Xiaokuang , Chen Tiejin , Hao Yongliang , Wang Pengfei , Ge Jiechao 
Published: January 2024

AbstractNanozyme‐based metabolic regulation triggered by tumor‐specific endogenous stimuli has emerged as a promising therapeutic strategy for tumors. The current efficacy, however, is constrained by the limited concentration of endogenous substrates and the metabolic plasticity of tumors. Consequently, the implementation of efficient metabolic regulation in tumor therapy is urgently needed. Herein, a versatile nanozyme‐based nicotinamide adenine dinucleotide (NADH) circulating oxidation nanoreactor is reported. First, the synthesized cobalt‐doped hollow carbon spheres (Co‐HCS) possess NADH oxidase (NOX)‐mimicking activity for the NADH oxidation to disrupt oxidative phosphorylation (OXPHOS) pathway of tumor cells. Second, the substrate‐cycle manner of Co‐HCS can be used for NADH circulating oxidation to overcome the limitation of substrate deficiency. Finally, 2‐Deoxy‐D‐glucose (2‐DG) and 6‐aminonicotinamide (6‐AN) are introduced to block glycolysis and pentose phosphate pathway (PPP), thus creating a versatile nanozyme‐based NADH circulating oxidation nanoreactor (Co‐HCS/D/A) for tumor therapy through triple cellular metabolism disruption. In vitro and in vivo results demonstrate that the designed nanoreactor not only enhances the catalytic efficiency but also disrupts the tumor metabolic homeostasis, leading to efficient therapy outcome. This study develops a novel NADH circulating oxidation nanoreactor for tumor therapy through triple cellular metabolism disruption, which addresses the limitations of current nanozyme‐based metabolism regulation for tumor therapy.