bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetra-primers ARMS-PCR-based analyses of the involvement of intronic variation in the FTO gene for the risk of developing knee osteoarthritis
Authors: Khan Bushra , Kumar Ranjeet , Sahar Najmus , Saifullah Saifullah 
Published: October 2023

Abstract
Genetic polymorphism in FTO was reported to disturb energy homeostasis, mediating obesity that may lead to OA. Therefore, the study aims to detect the presence of the FTO genetic variant, rs8044769, in patients of OA and to analyze the association of the genetic polymorphism with the disease. Case-control research was conducted at the University of Karachi between March to September 2022. Diagnosed OA patients, based on the ACR criteria, were enrolled from the T.O. Clinic and SouthCity Hospital, Karachi, Pakistan. Blood samples were collected from 125 OA patients and 125 healthy individuals with informed consent. Genomic- DNA was isolated, and genetic variations were analyzed. A significant association was observed between rs8044769 genotypes and susceptibility to OA (χ2 = 7.82, df = 2, P < 0.05). The minor allele of the FTO-rs8044769 had a significant association with the disease risk among the studied participants (OR = 1.729, 95% CI = 1.214 − 2.464, P = 0.002). In the female cohorts, rs8044769 conferred the disease susceptibility at the co-dominant, CC v/s TT (OR = 2.71, 95% CI = 1.09 − 6.76, P = 0.03); recessive, TT v/s CC + CT (OR = 2.17, 95% CI = 1.03 − 4.56, P = 0.04); additive, 2TT + CT v/s 2CC + CT (OR = 1.65, 95% CI = 1.05 − 2.61), P = 0.02) and allelic C v/s T (OR = 1.81, 95% CI = 1.11 − 2.96, P = 0.01) levels. There is a positive association of the FTO gene polymorphism with disease development in OA patients.
Spatial distribution and health risk assessment of soil petroleum hydrocarbons at an oil refinery in northwest China
Authors: Bai Jinjing , Jiang Jing , Yan Zengguang , Wang Qihao , Zhang Chao , Yang Pingguo , Yang Min 
Published: October 2023

Abstract
In the present study, the concentrations of six petroleum hydrocarbons, including n-alkane hydrocarbons (total petroleum hydrocarbons [TPH] (C6–C9) and (C10–C40)), BTEX(benzene, toluene, ethylbenzene, and m- and p-xylene), in 261 soil (0–14 cm), 31 groundwater, and 4 soil gas samples were measured to determine their spatial distribution and human health risks. The study integrated the model by Johnson and Ettinger and the HJ 25.3–2019 technical standards for risk assessment of soil contamination with localized parameters using Chinese demographic characteristics and site features to determine Health risk assessments. The results revealed that TPH (C6–C9) was the main contaminant in oil refineries, and the m- and p-xylene concentrations exceeded the screening values in groundwater and soil gas but not in soil. According to the spatial distribution characteristics, the contaminants were mainly concentrated in the refining workshop and around the storage tank, and the migration ability of linear-chain petroleum hydrocarbons in the soil was stronger than that of BTEX. TPH (C6–C9), TPH (C10–C40), and benzene in soil and groundwater pose a threat to human health. The pathway of steam invasion in soil gas and the carcinogenic risk and hazard quotient assessment of benzene in soil gas were 0–4 and 1–3 orders of magnitude higher than those in soil. Aliphatic hydrocarbons [AHCs] (C10–C12) had the highest non-carcinogenic risk among all TPH (C10–C40) parts. The present study provides a reference to accurately determine the toxicological parameters of TPH (C6–C9) and TPH (C10–C40) and to improve the BTEX risk assessment methods.
Chromosomes and the Mitotic Cell Cycle Phase in Onion Roots
Authors: Gupta Shalini 
Published: October 2023

Abstract
Onions (Allium cepa) are commonly employed in vitro to evaluate the effects of chemical agents. Onion chromosomes have long been prepared using the acetic orcein staining technique. However, aceto-orcein stain is corrosive and deadly since it contains oxidizing agents like organic peroxides, toxic compounds like cyanides, acid corrosives, and radioactive materials. This study examined the mitotic activity in the roots of onion plants to ascertain the impact of the aceto orcein dye's soaking period on actively dividing root cells. Using the aceto-orcein squash procedure, a number of root tips from each bulb were collected, soaked for 1, 3, and 24 hours in aceto-orcein stain, and then processed further for cytological analyses. The purpose of the research was to examine the impact of chromosomal aberration and mitotic index on onion roots. It will reveal how many cells are actually going through mitosis. The tip of onion root cells was observed going through mitosis while actively undergoing mitotic division using the usual methods. There are various phases involved in mitotic divisions, including prophase, metaphase, anaphase, telophase, and interphase. At each soaking time, the experiment was run six times. The outcome shown that different soaking time durations had a substantial impact on the decline in mitotic index value.
Adsorptive removal of Cr(VI) and Cu(II) ions from aqueous solutions by a natural moss
Authors: Ozeken Sengul Tugba , Ozdes Duygu , Duran Celal 
Published: October 2023

Abstract

The aim of the present research is to develop a new, fast, and easily applicable adsorption method for the removal of hazardous Cr(VI) and Cu(II) ions from the polluted industrial wastewater by using Racomitrium ericoides (Brid.) Brid. (REB), a type of moss. Although there are studies in the literature in which different moss species were used for the removal of heavy metals (HMs), REB was used for the first time in this study. Adsorption experiments were carried out through a batch system. The impact of significant experimental parameters showed that the optimum values of initial pH were 2.0 for Cr(VI) retention and 5.0 for Cu(II), and 360 min was selected as the optimum contact time for both HMs. An artificial neural network (ANN) model was applied to create a predictive model for the uptake efficiency of HMs. Adsorption kinetics of Cr(VI) and Cu(II) ions followed the pseudo-second order model. The maximum adsorption capacities of REB identified through the Langmuir model were 41.2 mg g−1 for Cr(VI) and 22.7 mg g−1 for Cu(II) ions. The results of the study demonstrated that REB can be utilized as an abundant, low-cost, and effective adsorbent in removal of HMs from aqueous solutions.
In-silico Assessment of Polyherbal Oils as Anti-diabetic Therapeutics
Authors: Bahl Amul S. , Verma Vipin Kumar , Prajapati Vaishali , Bhatia Jagriti , Arya Dharamvir Singh 
Published: October 2023

Background:
Diabetes mellitus (DM) is characterized by elevated blood glucose levels
either due to insufficient insulin production, defective insulin action, or both. It affects nearly
537 million individuals worldwide. Pharmacological treatment involves the use of oral antidiabetic
agents as mono or combination therapy that effectively aids in controlling hyperglycemia.
Despite providing therapeutic benefits, these medications limit their use owing to adverse
side effects. Certain natural products, including essential oils, have promising anti-diabetic
properties.

Objective:
The present study explores the effectiveness of two polyherbal oils and their compound
towards the treatment of DM based on an In-silico approach to drug investigations.

Methods:
Compounds present in the polyherbal oil formulation were identified using GCMS/
MS analysis. Selected compounds undergo molecular docking with the receptor, and proteins
play an important role in DM. The potential compounds showing higher interactions than
the known inhibitors or inducers were evaluated using molecular dynamic simulations RMSD
values.

Results:
The compounds identified through GC-MS analysis possess anti-diabetic and antiinflammatory
properties. With the aid of in silico prediction methods, compounds such as geraniol,
cinnamaldehyde, anethole, caryophyllene, terpinyl acetate, cymene, linalool, menthol,
Phenol,2-methoxy-3-(2-propenyl), and 2,6- octadienal,3,7-dimethyl were identified as strong
binders of GLUT4 and insulin receptor proteins. Geraniol and Phenol,2-methoxy-3-(2-propenyl)
interaction with GLUT4 were of particular importance owing to their conformational stability.

Conclusion:
Our data suggest an agonistic effect of compounds on target proteins aiding in enhanced
insulin activity and could serve as a potential anti-diabetic agent.
Assessment of utilized species of macrofungi and evaluation of mycochemical composition and bioactive properties of Phellinus robiniae collected from Benguet Province, Philippines
Authors: De Leon Angeles , Evangelista TRL , Morales, Jr. ND , Undan Jerwin , Kalaw Sofronio 
Published: October 2023

Macrofungi have long been used as food, medicine and other purposes. Several studies have been conducted on various macrofungi, however little is known about the wild useful macrofungi from the mountainous areas in the Philippines. Therefore, this study was conducted to document the diversity of wild utilized macrofungi in Kabayan, Benguet to come up with the species listing of wild utilized macrofungi in the area and assessment of the mycochemical composition, anti-oxidant activity and cytotoxic property of the basidiocarps of Phellinus robiniae. Seven wild utilized macrofungi were documented, all were identified morphologically, while four were subjected through molecular techniques to confirm identity; of the 7 mushrooms identified, five are edible (Hypholoma capnoides, Lentinula lateritia, Tremella fuciformis, Tremella mesenterica and Albatrellus confluens) and two are medicinal (Heterobasidion annosum and Phellinus robiniae). The identified mushrooms were: Hypholoma capnoides 92% (MF511082), Lentinula lateritia 99% (AF031192), Tremella fuciformis 94% (KY105682), Albatrellus confluens, Heterobasidion annosum 97% (KU645332), Tremella mesenterica and Phellinus robiniae. Assessment of bioactive properties of P. robiniae showed that the basidiocarp contains eleven bio-active secondary metabolites (essential oils, phenols, sugars, triterpenes, coumarines, anthraquinones, anthrones, tannins, alkaloids, flavonoids and steroids). This study also revealed that P. robiniae exhibited anti-oxidant activity with a DPPH radical scavenging activity of 34.59% and a total phenolic content of 49.42 mg GAE/g. Moreover, the ethanolic extract of P. robiniae showed an LC50 of 328.05 ppm which is considered as moderately toxic. This study provides baseline information on the utilized species of wild mushrooms that are found in the area.
MEMBONGKAR SISI GELAP FINTECH PEER-TO-PEER LENDING (PINJAMAN ONLINE) PADA MAHASISWA DI YOGYAKARTA
Authors: Hidayah Ahmad 
Published: October 2023

This study aims to discuss dismantling the dark side of fintech peer-to-peer lending (online lending) to college students in Yogyakarta. This study uses qualitative research methods and was conducted in the city of Yogyakarta. The results of this study state that the reason why college students in Yogyakarta City use and borrow money at illegal peer-to-peer lending fintech (online lending) is the ease of registration and disbursement of funds as well as their hedonism needs. After all, they have to accept how the dark side of fintech peer-to-peer lending (online lending) is illegal which is so detrimental. Therefore, it is necessary to inculcate the value of financial literacy from an early age therefore that this does not happen again.
PERAN INDONESIA DALAM PERGOLAKAN KAPITALIS BARU: PLATFORM PENYEDIA JASA PENGINAPAN OYO HOTELS DAN REDDOORZ
Authors: Saputra Hanafi 
Published: October 2023

This study reads the phenomenon of new platform capitalism from a sociological perspective. This study will critically discuss what is a platform based business model? How has the development of a platform based business model developed and has a positive impact on the Indonesian economy in the field of lodging services? and whether Indonesia is in the position of a player or even just as a worker in the digital economy era in the era of the industrial revolution 4.0, especially on the platforms of lodging service providers Oyo Hotels and RedDoorz. Furthermore, the authors can conclude that technological developments and economic globalization have given birth to a new form of capitalism, namely economic digitization in the form of platforms especially in the field of lodging service providers, namely Oyo Hotels and RedDoorz.
The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin
Authors: Tandi Joni , Marsella Mimi , Suarsana I Made Agus , Dewi Niluh Puspita , Magfirah Magfirah , Handayani Tien Wahyu , Kanan Maria 
Published: October 2023

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.
Narrative Imagination of Islam in Nusantara: A Study on Islam in Babad Tanah Jawi and Babad Giyanti
Authors: Achmad Fawaid  , Wening Udasmoro  , Sri Margana  , Miftahul Huda  
Published: October 2023

The lack of research on literary elements in "babad" is in line with the limited study of Islamic elements within this genre. This research aims to analyze the Javanese poets' depictions of Islam in "Babad Tanah Jawi" and "Babad Giyanti." The study operates under the assumption that "babad" as literary works can allegorically create a contested space where Islam interacts with other traditions. A qualitative paradigm with a comparative structural approach is employed in this study, focusing on the narratives that shape the author's understanding of Islam in the 18th century. The findings of this research reveal that the court poet's portrayal of Islam in "Babad Tanah Jawi" shares similarities with another work in the same genre, "Babad Giyanti." These commonalities encompass the utilization of Islamic verses in the "bhabuka" text and "asmaul husna," the depiction of "walisongo's" role, the practice of "tawajjuh," moral Islamic teachings, and the political positioning characterized by ambivalence and negotiation among different traditions.
Deskripsi Teknik Permainan Gitar Klasik Karya Antonio Lauro: Vals Venezolano no. 2
Authors: Waruwu Dian Kurnia Cristin , Tulus Handra Kadir  
Published: October 2023

Penelitian ini bertujuan untuk mengetahui karakteristik dan teknik yang terdapat dalam lagu Vals Venezolano. No 2 Karya Antonio Lauro melalui permainan gitar klasik oleh Ana Vidovic pada video pertunjukannya tahun 2015 di gedung Asamsaal Ettlingen, Jerman. Tavi jinariu, pada akun Youtube Elite Guitarist tahun 2018. Penelitian ini bersifat deskriptif dengan pendekatan kualitatif, dalam hal ini akan mendeskripsikan, menguraikan dan menggambarkan tentang karakteristik dan teknik serta metode latihan untuk dapat menguasai tenik tersebut. Objek penelitian menjadi pusat perhatian dan sasaran penelitian adalah teknik permainan gitar klasik dalam Vals Venezolano No. 2 karya Antonio Lauro. Instrument penelitian ini yaitu peneliti sendiri dengan dibantu beberapa perangkat alat untuk mengolah data seperti, alat perekam audio dan audio visual, lembaran pencatatan dan pedoman wawancara. Jenis data menggunakan data primer diambil dari partitur Vals Venezolano No. 2 karya Antonio Lauro dan data sekunder ambil dari video rekaman dari Youtube, buku-buku atau literatur dan wawancara dengan ahli. Langkah dalam menganalisis data adalah perolehan wawancara dari narasumber, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa teknik yang digunakan pada gitar klasik karya Antonio Lauro: Vals Venezolano No. 2 yakni apoyando, tirando, harmonic, barre, slur. Karakteristik dalam lagu ini yaitu rubato, sinkopasi, hemiola, con grazia dan waltz. Dalam tekni permainan khusus Ana Vidovic menambahkan harmonic 3 dawai pada fret 12 sebagai gaya permainan penutup dari Ana Vidovic pribadi yang tidak ada tercantum pada score.
Pembelajaran Seni Budaya (Teater) di Kelas XI IPS 3 SMA Negeri 1 Lintau Buo Utara
Authors: Permata Ayunda  , Marzam  
Published: October 2023

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan pembelajaran seni budaya (teater) di kelas XI IPS 3 di SMA Negeri 1 Lintau Buo. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Instrumen penelitian adalah peneliti sendiri dan di bantu dengan alat pendukung seperti alat tulis dan kamera. Teknik pengumpulan data meliputi observasi, studi pustaka, wawancara dan studi dokumentasi. Langkah-langkah menganalisis data adalah, reduksi data, penyajian data, dan kesimpulan. Hasil penelitian menunjukkan bahwa kegiatan pelaksanaan pembelajaran seni budaya (teater) di kelas XI IPS 3 SMA Negeri 1 Lintau Buo dengan menggunakan kurikulim 2013 belum sesuai dengan silabus dan Rencana Pelaksanaan Pembelajaran (RPP) yang di rancang oleh guru seni budaya (teater) di kelas XI IPS 3 di SMA Negeri 1Lintau Buo, sehingga berdampak pada kurangnya pemahaman peserta didik tentang pementasan seni teater sesuai dengan teknik dan prosedur perancangan pementasan seni teater. Agar tercapainya tujuan pembelajaran dan hasil belajar, guru harus memperhatikan silabus dan Rencana Pelaksanaan Pembelajaran (RPP) yang telah di rancang dan dapat di terapkan pada proses pelaksanaan pembelajaran mengenai pementasan seni teater tersebut.
Pendekatan Kreatif Penciptaan Tari Anak-Anak: Tari Kipas di Sanggar Galatiak Pitameh Kota Padang
Authors: Adinda Rahmasari Putri  , Darmawati  
Published: October 2023

Penelitian ini bertujuan untuk mendeskripsikan Pendekatan Kreatif Penciptaan Tari Anak-Anak: Tari Kipas di Sanggar Galatiak Pitameh Kota Padang. Jenis penelitian menggunakan metode deskriptif dari penelitian kualitatif. Objek penelitiannya tari Kipas di sanggar Galatiak Pitameh kota Padang dan difokuskan pada pendekatan kreatif penciptaannya. Teknik pengumpulan data yaitu teknik pustaka, observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa pendekatan kreatif penciptaan tari Kipas Sanggar Galatiak Pitameh memiliki tiga tahapan, (1) Tahap eksplorasi, yaitu tahapan yang memiliki kepekaan rasa terhadap objek, dengan mendengarkan musik yang sudah dipilih sebagai musik pengiring pada tari Kipas. (2) Tahap improvisasi yaitu daya imajinasi dan daya fikir berkonsentrasi pada objek, dalam improvisas lebih luas mengembangkan daya imajinasinya yang telah didapat pada proses eksplorasi. Melakukan gerak secara spontan yang muncul dari suatu kesadaran diri sendiri, menggunakan gerakan-gerakan bebas dalam menggunakan kipas sebagai properti, dengan menunjukkan ekspresi wajah gembira. Pada tahap ini langsung dipraktekkan hasil pencarian gerak kepada penari, namun pada proses penari cilik juga memiliki daya kreatif. Dari mereka memiliki spontan terhadap gerak yang diberikan sehingga lebih bervariasi dalam pembawaannya. (3) Tahap pembentukan yaitu, proses klimak dari tahap pembentukan yang artinya sudah selesai, mengubah bentuk gerak dari tahap-tahap sebelumnya, kemudian berusaha membentuk gerak menjadi gerakan tarian yang utuh.
Analisis Korelasi Pemberian Makanan Pendamping ASI (MPASI) dengan Kejadian Diare pada Bayi Usia 0-6 Bulan
Authors: Rahman Taufiqur , Iszakiyah Nur , Amir Faisal 
Published: October 2023

Asupan nutrisi yang sehat dan seimbang diperlukan oleh bayi untuk pertumbuhan fisik, perkembangan mental dan kesehatan secara umum. Hal ini bisa tercapai salah satunya melalui pemahaman yang baik dan benar terkait kesesuaian pemberian Air Susu Ibu (ASI) eksklusif dan Makanan pendamping ASI (MPASI) terutama pada usia 0-6 bulan pertama. Penelitian ini bertujuan untuk mengetahui hubungan pemberian makanan pendamping ASI (MPASI) dengan kejadian diare pada bayi usia 0-6 bulan di Desa Teja Barat Wilayah Kerja UPT Puskesmas Teja Kabupaten Pamekasan. Design penelitian ini adalah ananalitik korelasi dengan pendekatan retrospektif. Populasi sejumlah 30 dan sampel sejumlah 22 yang diambil dengan tehknik simple random sampling. Uji statistik menggunakan Chi Square dengan α < 0,05. Hasil penelitian menunjukkan bahwa sebagian besar yaitu 59% responden yang diberikan MPASI tidak mengalami diare. Hasil uji statistik menggunakan Chi square didapatkan p value 0.217 > 0.05 . Artinya tidak ada hubungan signifikan antara pemberian MPASI dengan kejadian diare pada bayi usia 0-6 bulan di Desa Teja Barat Wilayah Kerja UPT Puskesmas Teja Kabupaten Pamekasan Tahun 2019. Hal ini mungkin karena MPASI bukan satu-satunya etiologi penyebab diare, akan tetapi banyak faktor yang mempengaruhi terjadinya diare. Selain itu ibu juga memahami kaidah pemberian MPASI, berkonsultasi dengan petugas kesehatan dan menjaga kebersihan.
Supportif Edukatif Berbasis Keluarga Berhubungan dengan Penurunan Fungsi Kognitif pada Lansia
Authors: Shafiyah Faizatus , Damayanti Cory Nelia , Hidayat Syaifurrahman , Wardita Yulia 
Published: October 2023

This study aims to determine the relationship between family-based educational support and cognitive decline in the elderly in the coastal village of Sumenep Regency, Batangbatang, East Legung. This research was conducted for three months, from May to July 2021. The subjects of this study were 60-70 years old who lived with their families.
The research method is a cross-sectional study. This study uses a sampling technique based on distrust through purposeful sampling. Data was collected using a questionnaire and a mini-test from the Mental State Survey using the Spearman's Rank Statistical Test.
As a result, of the 40 respondents, an average of 30 (75.0%) of the total respondents were elderly who received adequate family education support, and it was found that the majority of the elderly experienced moderate cognitive decline, namely 28 (70.0%) with a ranking test. Spearman's results with a value of 0.001. In conclusion, there is a relationship between family education support and cognitive decline in the coastal elderly in the villages of Sumenep, Batangbatang, and Legung Timur districts