bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Non‐Surgical Mechanical Therapy on the Subgingival Microbiota of Brazilians With Untreated Chronic Periodontitis: 9‐Month Results
Authors: Colombo Ana Paula Vieira , Teles Ricardo Palmier , Torres Maria Cynésia , Rosalém Wilson , Mendes Maria Cláudia S. , Souto Renata M. , de Uzeda Milton 
Published: May 2005

Background: Mechanical periodontal therapy is the most common treatment of periodontal infections. It is directed primarily towards removing biofilm and calculus from the root surfaces, leading to ecological changes in the subgingival environment. Thus, the purpose of this study was to evaluate the effects of scaling and root planing (SRP) on the subgingival microbiota of Brazilian subjects with untreated chronic periodontitis over a 9‐month period.Methods: Twenty‐five untreated chronic periodontitis patients (mean age 43 ± 5 years; 20% smokers; 45% males) were selected from a Brazilian population. At baseline, probing depth (PD), clinical attachment level (CAL), visible supragingival biofilm (SB), bleeding on probing (BOP), and suppuration (SUP) were measured at six sites/tooth. Subgingival plaque samples were obtained from 10 sites with the deepest PD (≥5 mm) of each subject and tested for the presence of 25 oral species by DNA probes and the checkerboard technique. Patients received full mouth SRP and oral hygiene instructions. Clinical and microbiological assessments were repeated at 3, 6, and 9 months after therapy. During this period, all patients received maintenance therapy, including supragingival prophylaxis and reinforcement in home care procedures. The clinical and microbiological parameters examined were computed for each subject and at each visit. Differences over time were sought using the Friedman test.Results: Significant reductions in mean CAL and PD (P <0.01), percent of sites with SB (P <0.01), BOP and SUP (P <0.05) were observed during the course of the study. In general, microbial changes were more pronounced for the mean counts than for the frequency of the microorganisms, particularly at 3 months post‐therapy. Significant reductions in prevalence and levels were observed for certain periodontal pathogens including P. gingivalis (P <0.05; P <0.01), T. forsythensis (P <0.01), C. rectus (P <0.01), and A. actinomycetemcomitans (P <0.01; P <0.05). Nevertheless, the frequency of A. actinomycetemcomitans increased to baseline values at 9 months after therapy. Treponema ssp. and Prevotella spp. showed a modest decrease in prevalence, whereas marked reductions in their levels were observed. In contrast, the frequency and counts of the suspected pathogens P. micros and F. nucleatum increased after treatment. Species considered beneficial including Actinomyces spp., some oral streptococci, and V. parvula increased in prevalence, although these two last species tended to return to baseline levels at 9 months.Conclusion: In Brazilians with untreated chronic periodontitis, SRP led to clinical improvement associated with a decrease of certain periodontal pathogens, and an increase of beneficial species for up to 9 months after therapy. J Periodontol 2005;76:778‐784.
Interleukin‐18 Concentrations and the Pathogenesis of Periodontal Disease
Authors: Johnson R.B. , Serio F.G. 
Published: May 2005

Background: Interleukin‐18 (IL‐18) is reported as an important regulatory cytokine in non‐oral inflammation. Our objective was to compare the concentrations of IL‐18 within diseased and healthy human gingiva with concentrations of other TH1 and TH2 cytokines to determine possible effects of IL‐18 on gingival inflammation.Methods: Gingival biopsies were obtained prior to routine tooth extraction. Gingiva was grouped by the depth of the adjacent gingival sulcus: ≤3 healthy (featuring no bleeding on probing) and ≥3 mm diseased (featuring bleeding on probing). Diseased gingiva was subdivided into 3, 4 to 6 and >6 mm groups. Gingival interleukin (IL)‐2, IL‐4, IL‐6, IL‐10, IL‐12, IL‐18, and interferon (IFN)‐γ concentrations were assessed by enzymelinked immunosorbent assay (ELISA). Data were compared by factorial analysis of variance and the Pearson's correlation test.Results: Concentrations of IL‐2, IL‐4, IL‐6, IL‐10, IL‐18, and IFN‐γ adjacent to 4 to 6 mm diseased sites were greater than adjacent to ≤3 mm healthy sites (P <0.001). IL‐12 concentrations were lower within diseased than within healthy gingiva (P <0.001). IL‐6 and IL‐18 concentrations were greater adjacent to >6 mm sites compared to healthy sites (P <0.001); the concentrations of the other cytokines (except IL‐12) were similar to healthy sites. IL‐6 and IL‐18 concentrations were positively correlated, and IFN‐γ and IL‐12 negatively correlated, with the adjacent gingival sulcular depth.Conclusions: Periodontal inflammation may not successfully resolve because of accumulation of IL‐6 and IL‐18, and decreased concentrations of IL‐12, within diseased gingiva. Because of the highly significant correlation between IL‐18 concentration and gingival sulcular depth, IL‐18 may be a useful target for either preventive or palliative therapy for periodontitis. J Periodontol 2005;76:785‐790.
Crestal Bone Changes Around Titanium Implants. Part I: A Retrospective Radiographic Evaluation in Humans Comparing Two Non‐Submerged Implant Designs With Different Machined Collar Lengths
Authors: Hänggi Michael P. , Hänggi Daniel C. , Schoolfield John D. , Meyer Jürg , Cochran David L. , Hermann Joachim S. 
Published: May 2005

Background: Experimental studies demonstrated that peri‐implant crestal hard and soft tissues are significantly influenced in their apico‐coronal position by the rough/smooth implant border as well as the microgap/ interface between implant and abutment/restoration. The aim of this study was to evaluate radiographically the crestal bone level changes around two types of implants, one with a 2.8 mm smooth machined coronal length and the other with 1.8 mm collar.Methods: In 68 patients, a total of 201 non‐submerged titanium implants (101 with a 1.8 mm, 100 with a 2.8 mm long smooth coronal collar) were placed with their rough/smooth implant border at the bone crest level. From the day of surgery up until 3 years after implant placement crestal bone levels were analyzed digitally using standardized radiographs.Results: Bone remodeling was most pronounced during the unloaded, initial healing phase and did not significantly differ between the two types of implants over the entire observation period (P >0.20). Crestal bone loss for implants placed in patients with poor oral hygiene was significantly higher than in patients with adequate or good plaque control (P <0.005). Furthermore, a tendency for additional crestal bone loss was detected in the group of patients who had been diagnosed with aggressive periodontitis prior to implant placement (P = 0.058). In both types of implants, sand‐blasted, large grit, acid‐etched (SLA) surfaced implants tended to have slightly less crestal bone loss compared to titanium plasma‐sprayed (TPS) surfaced implants, but the difference was not significant (P >0.30).Conclusion: The implant design with the shorter smooth coronal collar had no additional bone loss and may help to reduce the risk of an exposed metal implant margin in areas of esthetic concern. J Periodontol 2005;76:791‐802.
Reactive Correction of a Maxillary Incisor in Single‐Tooth Crossbite Following Periodontal Therapy
Authors: Huang Chih‐Hao , Brunsvold Michael A. 
Published: May 2005

Background: The reactive correction of a singletooth anterior crossbite following periodontal therapy is described. This case report provides new information regarding correction of a crossbite relationship and con‐ firms existing reports of tooth movement following periodontal therapy.Methods: A 39‐year‐old woman in good general health presented with a history of recurrent periodontal abscesses of a maxillary incisor. Probing depths of the abscessed tooth ranged from 5 to 12 mm, and class 1 mobility was noted. Radiographs revealed that the tooth had previously been treated endodontically. The patient's periodontal diagnosis was generalized chronic moderate to severe periodontitis. Treatment considerations were complicated by a single‐tooth crossbite relationship of the involved incisor and clinical evidence that the periodontal abscess communicated with an apical infection. Treatment of the abscess consisted of cause‐related therapy, bone grafting, and occlusal adjustment.Results: Five months after surgical treatment, an edge‐to‐edge incisal relationship was observed, the first indicator of tooth movement. Further correction to a normal incisal relationship resulted 1 year after modi‐ fication of the proximal contact. At this time, there was normal probing depth with only slight recession and mobility. Bone fill was radiographically noted.Conclusion: It appears that some cases of maxillary incisor crossbite that are complicated by periodontal disease may be corrected, without orthodontic appliances, following periodontal treatment. J Periodontol 2005;76:832‐836.
Tertiary microvascular territories define lacunar infarcts in the basal ganglia
Authors: Feekes Joel A. , Hsu Shih‐Wei , Chaloupka John C. , Cassell Martin D. 
Published: May 2005

AbstractLacunar infarcts are commonly found in the basal ganglia, though little is known about the organization of small‐scale microvascular territories that presumably subtend lacunae. We investigated microvascular territories of the lenticulostriate arteries, the recurrent artery of Heubner, the anterior choroidal artery, and striate branches of the anterior cerebral and anterior communicating arteries in perfusion‐fixed human brains by simultaneous injection of fluorescent dyes and a radio‐opaque substance in 5% gelatin. Territories were defined by ultraviolet illumination of dye and high‐resolution mammography of radio‐opaque substance. Brains were sectioned coplanar with the Talairach proportional grid system and vascular data were plotted, allowing for application to any human brain. The data suggest first that the lenticulostriate artery, recurrent artery of Heubner, and anterior choroidal artery supply distinct territories of the basal ganglia with minimal overlap and sparse anastomoses between major penetrating vessels. Individual territories are spatially consistent across brains and match the extent of major/minor infarcts. Second, branching patterns of parental, second‐, and third‐order vessels leading to circumscribed terminal vascular beds could account structurally for “lacunar” infarcts. Ann Neurol 2005
Inhibitoren der Proteintyrosinphosphatasen: Kandidaten für zukünftige Wirkstoffe?
Authors: Bialy Laurent , Waldmann Herbert 
Published: May 2005

AbstractProteintyrosinphosphatasen (PTPs) bilden eine Familie eng verwandter regulatorischer Schlüsselenzyme, die Phosphotyrosinreste in ihren Proteinsubstraten dephosphorylieren. Fehlfunktionen der PTPs wurden mit mehreren Krankheiten in Verbindung gebracht, darunter mit Krebs, neurologischen Störungen und Diabetes, weshalb PTPs seit einigen Jahren als Angriffspunkte (Targets) therapeutischer Eingriffe untersucht werden. Dieser Aufsatz diskutiert allgemeine Aspekte von PTPs sowie akademische und pharmazeutisch‐industrielle Forschungsaktivitäten zur Entwicklung niedermolekularer Inhibitoren von PTPs. Zur Identifizierung wirksamer und selektiver Inhibitoren wurden unterschiedliche Strategien erfolgreich angewendet. Diese Studien bilden die Grundlage für eine mögliche künftige Entwicklung von PTP‐Inhibitoren als Wirkstoffen.
Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: Dynamic cell seeding and construct development
Authors: Zhao Feng , Ma Teng 
Published: May 2005

AbstractHuman mesenchymal stem cells (hMSCs) have great potential for therapeutic applications. A bioreactor system that supports long‐term hMSCs growth and three‐dimensional (3‐D) tissue formation is an important technology for hMSC tissue engineering. A 3‐D perfusion bioreactor system was designed using non‐woven poly (ethylene terepthalate) (PET) fibrous matrices as scaffolds. The main features of the perfusion bioreactor system are its modular design and integrated seeding operation. Modular design of the bioreactor system allows the growth of multiple engineered tissue constructs and provides flexibility in harvesting the constructs at different time points. In this study, four chambers with three matrices in each were utilized for hMSC construct development. The dynamic depth filtration seeding operation is incorporated in the system by perfusing cell suspensions perpendicularly through the PET matrices, achieving a maximum seeding efficiency of 68%, and the operation effectively reduced the complexity of operation and the risk of contamination. Statistical analyses suggest that the cells are uniformly distributed in the matrices. After seeding, long‐term construct cultivation was conducted by perfusing the media around the constructs from both sides of the matrices. Compared to the static cultures, a significantly higher cell density of 4.22 × 107 cell/mL was reached over a 40‐day culture period. Cellular constructs at different positions in the flow chamber have statistically identical cell densities over the culture period. After expansion, the cells in the construct maintained the potential to differentiate into osteoblastic and adipogenic lineages at high cell density. The perfusion bioreactor system is amenable to multiple tissue engineered construct production, uniform tissue development, and yet is simple to operate and can be scaled up for potential clinical use. The results also demonstrate that the multi‐lineage differentiation potential of hMSCs are preserved even after extensive expansion, thus indicating the potential of hMSCs for functional tissue construct development. The system has important applications in stem cell tissue engineering. © 2005 Wiley‐Periodicals, Inc.
Low‐molecular‐weight heparin vs. unfractionated heparin in percutaneous coronary intervention: A combined analysis
Authors: Borentain Maria , Montalescot Gilles , Bouzamondo Anissa , Choussat Rémi , Hulot Jean‐Sébastien , Lechat Philippe 
Published: May 2005

AbstractThis meta‐analysis assessed the rates of the efficacy and safety endpoints with intravenous low‐molecular‐weight heparin (LMWH) compared with unfractionated heparin (UFH) in patients undergoing percutaneous coronary intervention (PCI). Subcutaneous LMWH has compared favorably with UFH, but limited experience exists with intravenous LMWH for immediate anticoagulation in PCI. The meta‐analysis included data from eight randomized trials in which patients received LMWH (n = 1,037) or UFH (n = 978) during PCI. Seven additional nonrandomized studies/registries were analyzed to assess the efficacy and safety of LMWH during PCI. Efficacy endpoints were ischemic events (usually a composite of death, myocardial infarction, and urgent revascularization) and the safety endpoint was bleeding (major, minor, or all bleeding). In the randomized studies, LMWH was comparable with UFH in terms of efficacy (6.2% vs. 7.5%) and major bleeding (0.9% vs. 1.8%). The analysis of pooled data, randomized or not, suggests potential improved efficacy (5.8% vs. 7.6%) and reduced major bleeding (0.6% vs. 1.8%) with LMWH (n = 3,787) compared with UFH (n = 978). During PCI, intravenous LMWH without coagulation monitoring has the potential to be at least as safe and efficacious as intravenous UFH. Further studies of LMWHs in PCI are therefore required. © 2005 Wiley‐Liss, Inc.
Novel method for extraction of a massive refractory coronary thrombus after stent implantation
Authors: Yang Yi‐Ming , Stone Gregg W. , Moses Jeffrey W. , Leon Martin B. , Mintz Gary S. 
Published: May 2005

AbstractPercutaneous treatment of thrombotic coronary lesions is associated with an increased incidence of complications. In particular, management of massive coronary thrombus refractory to traditional methods of removal may be especially problematic. We report a novel application of the FilterWire distal protection device to retrieve a massive refractory native coronary thrombus present after drug‐eluting stent implantation. Catheter Cardiovasc Interv 2005. © 2005 Wiley‐Liss Inc.
Precursors of Biological Cofactors from Ultraviolet Irradiation of Circumstellar/Interstellar Ice Analogues
Authors: Meierhenrich Uwe J. , Muñoz Caro Guillermo M. , Schutte Willem A. , Thiemann Wolfram H.‐P. , Barbier Bernard , Brack André 
Published: May 2005

AbstractBiological cofactors include functionalized derivatives of cyclic tetrapyrrole structures that incorporate different metal ions. They build up structural partnerships with proteins, which play a crucial role in biochemical reactions. Porphyrin, chlorin, bacteriochlorin, and corrin are the basic structures of cofactors (heme, chlorophyll, bacteriochlorophyll, siroheme, F 430, and vitamin B12). Laboratory and theoretical work suggest that the molecular building blocks of proteins (α‐amino acids) and nucleic acids (carbohydrates, purines, and pyrimidines) were generated under prebiotic conditions. On the other hand, experimental data on the prebiotic chemistry of cofactors are rare. We propose to search directly for the pathways of the formation of cofactors in the laboratory. Herein we report on the detection of N‐heterocycles and amines in the room‐temperature residue obtained after photo‐ and thermal processing of an interstellar ice analogue under high vacuum at 12 K. Among them, hexahydro‐1,3,5‐triazine and its derivatives, together with monopyrrolic molecules, are precursors of porphinoid cofactors. Hexahydropyrimidine was also detected. This is the first detection of these compounds in experiments simulating circumstellar/interstellar conditions. Except for 2‐aminopyrrole and 2,4‐diaminofuran, which were only found in 13C‐labeled experiments, all the reported species were detected in both 12C‐ and 13C‐labeled experiments, excluding contamination. The molecules reported here might be present in circumstellar/interstellar grains and cometary dust and could be detected by the Stardust and Rosetta missions.
Luminescent Platinum(II) Terpyridyl Complexes: Effect of Counter Ions on Solvent‐Induced Aggregation and Color Changes
Authors: Yam Vivian Wing‐Wah , Chan Kenneth Hoi‐Yiu , Wong Keith Man‐Chung , Zhu Nianyong 
Published: May 2005

AbstractA series of platinum(II) terpyridyl complexes [Pt(tpy)(CCCCH)]X, 1‐X (X=OTf−; PF6−; ClO4−; BF4−; BPh4−); [Pt(tpy)(CCC6H5)]X, 2‐X (X=OTf−; PF6−; ClO4−; BF4−); [Pt(tpy)(CCC6H4OCH3‐4)]OTf, 3‐OTf, and [Pt(4′‐CH3O‐tpy)(CCC6H5)]OTf, 4‐OTf (tpy=2,2′:6′,2′′‐terpyridine, OTf=trifluoromethanesulfonate) were synthesized and their photophysical properties determined. Electronic absorption and emission studies showed the formation of a new band upon increasing the diethyl ether content in an acetonitrile/diethyl ether mixture. This was ascribed to the formation of complex aggregates, the solution color of which is dependent on the nature of the anions. This indicates that counter ions play an important role in governing the degree of aggregation and the extent of interactions within these aggregates. Addition of various anions to solutions of 1‐OTf and 1‐PF6 produced anion‐induced color changes upon solvent‐induced aggregation, indicating that these complexes may serve as potential colorimetric anion probes.
Does a Stabilising Interaction Favouring theZ,ZConfiguration of S‐NSN‐S Systems Exist?
Authors: Tersago Karla , Mandado Marcos , Van Alsenoy Christian , Bagryanskaya Irina Yu. , Kovalev Mikhail K. , Makarov Alexander Yu. , Gatilov Yuri V. , Shakirov Makhmut M. , Zibarev Andrey V. , Blockhuys Frank 
Published: May 2005

AbstractThe existence of the orbital interaction presented in the literature as being the cause for the stabilisation of theZ,Zconfiguration of Ph‐S‐NSN‐S‐Ph (1) and its derivatives in the crystal phase, has been investigated. The results of theoretical calculations at the DFT/B3LYP/6‐311+G* level of theory suggest that such a stabilising interaction might not exist or be extremely weak and that packing forces must be the main cause of the observedZ,Zconfiguration in the solid. To reach this conclusion structural and energetic parameters were combined to study the bonding in these ‐S‐NSN‐S‐ systems. For the analogous Ph‐Se‐NSN‐Se‐Ph (2) in particular the isomeric equilibrium in solution found in the variable‐temperature77Se NMR spectrum indicates that, in the gas phase or in solution, the observedZ,Zconfiguration is not stabilised to a greater extent than theZ,Econfiguration.
Extended Structures and Magnetic Properties of Lanthanide–Copper Complexes with Picolinic Acids as Bridging Ligands
Authors: Wu A‐Qing , Guo Guang‐Hua , Yang Chun , Zheng Fa‐Kun , Liu Xi , Guo Guo‐Cong , Huang Jin‐Shun , Dong Zhen‐Chao , Takano Yoshihiko 
Published: May 2005

AbstractThe first examples of 3d–4f heterometallic complexes containing picolinic acid ligands were synthesized and characterized. Three series of complexes were obtained by the reaction of presynthesized “metallo ligands” Cu(pic)2 and Ln(ClO4)3 in 2:1, 3:1, and 4:1 mole ratios. Complexes 1–3 (denoted as the first series), [LnCu2(pic)4(H2O)6](ClO4)3·H2O (Ln = Sm, Nd, and Pr), are isomorphous and exhibit infinite 1D zigzag chain structures with rare earth ions in tricapped trigonal prismatic coordination. Complexes 4–10 (denoted as the second series), [Ln2Cu5(pic)10(H2O)8](ClO4)6·2H2O (Ln = Gd, Nd, Sm, Dy, Eu, Pr, and Yb), are isomorphous too, and exhibit extended 2D layered structures constituted by Cu(pic)2 moieties bridging the zigzag chains. Complex 11 (denoted as the third‐type complex), {NdCu(pic)2[CO(NH2)2]4(H2O)3}(ClO4)3·[Cu(pic)2]2, exhibits another type of nearly linear chain structure with additional Cu(pic)2 moieties trapped in the lattice by hydrogen bonds. Temperature‐dependent magnetizations of complexes 2–4, 6, and 11 indicate that these complexes follow the Curie–Weiss paramagnetic behavior down to 5 K. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Lanthanide Complexes of Disulfoxide Ligands with Varied Configurations: Influence of Lanthanide Contraction on the Structures of the Complexes
Authors: Li Jian‐Rong , Zhang Ruo‐Hua , Bu Xian‐He 
Published: May 2005

AbstractFour new disulfoxide‐LnIII complexes, [Ln(L)2(NO3)3]n {Ln = La (1), n = n; Ln = Gd (2), Dy (3) and Yb (4), n = 2}, have been prepared by the reaction of Ln(NO3)3·nH2O with meso‐1,3‐bis(ethylsulfinyl)propane (meso‐L) in methanol/triethylorthoformate, and their solid‐state structures were characterized by IR spectroscopy, elemental analyses and X‐ray diffraction. Complex 1 is a 1D double‐bridged chain in which the LaIII ions are ten‐coordinate and the L ligands adopt both meso and rac configurations, and a bis‐monodentate bridging coordination mode. While complexes 2–4 have isostructural dinuclear structures, in which the LnIII ions are nine‐coordinate and the ligands show two types of coordination fashions and configurations: bis‐monodentate bridging with a meso‐configuration, and monodentate coordination with a rac‐configuration. The structural differences between 1 and 2–4 indicate the influence of lanthanide contraction on the complex structures. In addition, a change in configuration of the ligand occurs when it reacts with metal ions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)