bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoablation of the adenohypophysis in the treatment of chronic pain syndrome in patients with stage IV malignant neoplasms
Authors: Tsyhankov O.V. , Chyzh M.O. , Hladkykh F.V. 
Published: October 2023

Background. The data of the European Society For Medical Oncology (ESMO) indicate that 64.0% of cancer patients with the fourth stage of cancer have chronic pain syndrome, which is the main factor that significantly affects the quality of life. In 46.0% of patients, it is not possible to obtain a stable analgesic effect with modern methods of analgesia, including interventional methods and pharmacotherapy. Refractory oncological pain stimulates the search for new methods of pain relief.
Purpose – retrospective assessment of the effectiveness of the selective stereo- tactic transnasal transsphenoidal cryoablation of the adenohypophysis in the treatment of chronic pain syndrome in patients with stage IV malignant neoplasms.
Materials and methods. 45 microsurgeries were performed – stereotactic selective transnasal transsphenoidal cryoablation of the adenohypophysis with endoscopy. Over the period from 2014 to 2018, 45 patients with stage IV malignant hormone- dependent neoplasms of various somatic organs and chronic pain syndrome underwent microsurgery.
Results. The analgesic effect appeared 4–6 hours after the microsurgery. In 95.6% of patients, an analgesic effect was achieved to a greater extent (according to the numeric rating scale (NRS) for pain, its intensity decreased from 7–9 points to 1–3 points); in other patients, the analgesic effect was achieved to a lesser extent (according to the NRS, pain intensity decreased from 7–9 points to 3–5 points), regardless of the condition and age of the patient. Accordingly, the dosage was reduced or opioid analgesics were discontinued. Severe complications after the cryoablation of adenohypophysis, such as meningitis, diabetes insipidus, and hypopituitary syndrome were not observed. In the postoperative period, three patients were treated for mild hypopituitary syndrome, and two patients were treated for liquorrhea with conservative therapy for 3–5 days.
Conclusions. Stereotactic selective transnasal transsphenoidal cryoablation of the adenohypophysis is an effective microsurgery in the treatment of chronic pain syndrome in stage IV cancer patients. It improves the patient’s condition and quality of life. The analgesic effect appears in the first hours after surgery. Due to the use of cryoprobes with a diameter of 1.2 mm and 1.8 mm, the surgery is minimally traumatic and can be performed on patients in critical condition.
Oncolytic potential of autonomous parvoviruses
Authors: Buchatskyi L.P. 
Published: October 2023

Background. In many countries, more than 40 oncolytic viruses from 10 different families are undergoing clinical trials (phase I, II, III) against various types of cancer; some of them have already been approved for use. The results of the experimental studies that deal with the development of oncolytic drugs based on autonomous parvoviruses deserve special attention.
Purpose. The purpose of the study was to analyze and summarize literature sources that are concerned with the development of oncolytic drugs based on autonomous parvoviruses.
Materials and Methods. Publications were selected using keywords in PubMed (https://pubmed.ncbi.nlm.nih.gov/) and Google Scholar (https://scholar.google.com/) databases published over the period from 2010 to 2023.
Results. Among autonomous parvoviruses, protoparvoviruses are the most promising for the development of anticancer drugs. They detect CPE mainly in tumor cells, CPE is absent or limited in non-transformed human and rodent cell lines. Many of them are capable of actively replicating in cancer cells without destroying normal body cells. They primarily block the pathways of activation of type I interferons. The main non-structural viral protein NS1 plays a significant role in the manifestations of oncolytic activity of protoparvoviruses.
Conclusions. Numerous studies continue to be directed at studying the mechanisms associated with the oncolytic properties of autonomous parvoviruses. The use of recombinant parvoviruses allows their oncolytic potential to be enhanced.
Validity Test of Hamstring Muscle Strength Test for Handball Athletes
Authors: Firmansyah Awang , Ardy Kusuma Donny , Prijo Budijono Agung , Wahyudi Heri , Rusdiawan Afif , Lutfiatus Solikah Nur , Bayu Putro Andika 
Published: October 2023

The purpose of this study was to test the validity of hamstring muscle strength of handball athletes. A total of 30 handball athletes with categories of 15 male athletes (18.0 ± 5.1 years, weight 62.6 ± 20.7 kg, height 173.6 ± 5.0 cm, BMI 22.1 ± 4.0 kg / m2) and female (18.0 ± 5.1 years, weight 54.6 ± 17.4 kg, height 164.7 ± 6.9 cm, BMI 21.4 ± 2.2 kg/m2). No history of lower extremity injuries participated in a hamstring strength test. Hamstring strength tests are performed isometrically with ISO Prone and ISO 60 tests using nordbord tools and load cells tied using hooks called pabletest. From the test results there is a validity level of 0.000 with reliability of 0.8, so that the data can be said to be valid on both tests, namely ISO Prone and ISO 60. Load cells on pabletes are able to measure hamstring muscle strength in handball athletes. The advantages of load cells on pabletes can be made simply but not everyone can make arrangements so as to output data that can be interpreted. Subsequent research can be done using different contractions such as eccentrics and increasing the number of research subjects more by developing better software.
Keywords: validity, hamstring, muscle, strength, isometric
Efecto de un programa de ejercicio físico con enfoque sanológico en población universitaria (Effect of a physical exercise program with a sanológico focus on university population)
Authors: Andrés Sergio 
Published: October 2023

Objetivo: Determinar el efecto del programa de ejercicio físico, del proyecto institucional Usco saludable con enfoque sanológico, en universitarios con sobrepeso. Materiales y métodos: estudio cuasi experimental con valoración antes y después de un solo grupo con enfoque mixto, se seleccionaron 40 estudiantes con IMC (índice de masa corporal) entre los rangos de 25 a 30 kg/m2 de las revisiones de las historias clínico-sanológicas. Se utilizó un instrumento denominado Historia clínico-sanológica diseñada, ajustada y estandarizada por los investigadores Pedro Reyes Gaspar y Dolly Arias Torres. Los datos se trabajaron a través de entrevista semiestructurada mediante la creación de códigos, y categorías con el programa Software Atlas Ti 6, para la comparación del IMC se empleó la prueba de Wilcoxon y el tamaño del efecto mediante la G de Hedges en el programa SPSS versión 24. Resultados: se identificaron cambios significativos en el concepto de salud, estado de salud actual y en la comprensión del ejercicio físico como herramienta para el cuidado de la salud y envejecimiento. Conclusiones: La estrategia de ejercicio físico desde un enfoque sanológico es factible y eficaz debido a los cambios reveladores en el pensamiento y comportamiento en la salud de estudiantes universitarios con sobrepeso.
Palabras claves: promoción de la salud, universitarios, sobrepeso, ejercicio físico, estilo de vida.
Abstract. Objective: Determine the effect of the physical exercise program, of the healthy Usco institutional project with a sanológico approach, on overweight university students. Materials and methods: quasi-experimental study with before and after assessment of a single group with a mixed approach, 40 students with BMI (body mass index) between the ranges of 25 to 30 kg/m2 were selected from the reviews of clinical records sanológicas. An instrument called Clinical-Sanológica History designed, adjusted and standardized by researchers Pedro Reyes Gaspar and Dolly Arias Torres was used. The data were worked through a semi-structured interview by creating codes and categories with the Atlas Ti 6 Software program. For the comparison of BMI, the Wilcoxon test was used and the effect size was used using Hedges' G. SPSS program version 24. Results: significant changes were identified in the concept of health, current health status and in the understanding of physical exercise as a tool for health care and aging. Conclusions: The physical exercise strategy from a health approach is feasible and effective due to the revealing changes in the thinking and health behavior of overweight university students.
Keywords: health promotion, university students, overweight, physical exercise, lifestyle.
Nuevo registro del oso andino (Tremarctos ornatus, Carnivora: Ursidae) para el departamento de Caldas, Colombia
Authors: Aristizabal Daniela , Zúñiga-Baos Jorge A. 
Published: October 2023

En Colombia la fragmentación de ecosistemas naturales, las actividades agrícolas y ganaderas han generado perdida en el hábitat natural del oso andino (Tremarctos ornatus), por lo cual, sus registros no son frecuentes. Aquí reportamos un nuevo registro del oso para el municipio de Salamina, Norte del departamento de Caldas. El reporte fue obtenido por una cámara trampa, en un sector de relictos de bosque de galería en el orobioma Andino de la Cordillera Central.
The Implementation of Strategic Management: Using Balance Scorecard Method at The Department of Islamic Education of IAIN Kerinci
Authors: Zebua Ali Marzuki , Anwar Khairul 
Published: October 2023

Abstract: One of the main concerns of religious universities is the modernisation of education in terms of the quality of educational services. The transformation of the educational system with a focus on a competitive and high-quality output market necessitates strategic change management. This study aims to discover, characterize, and evaluate strategic management models in terms of quality. Presently, the Balanced Scorecard is considered to be an efficient quality measurement concept. This qualitative study employed comparative and interactive models design with both financial and non-monetary factors are being examined. The results demonstrated that the effectiveness of the Islamic Education program was preferable than that of its competitors (program). Furthermore, the Islamic Education Program is better compared to other undergraduate study programs in both financial and non-financial management.
Abstrak: Salah satu problematika perguruan tinggi keagamaan adalah respon terhadap modernisasi pendidikan pada sektor mutu layanan pendidikan. Untuk itu diperlukan manajemen strategi terhadap perubahan adalah transformasi sistem pendidikan dengan orientasi pasar output yang kompetitif dan berkualitas. Penelitian ini bertujuan untuk menganalisis, mendeskripsikan dan menemukan model manajemen strategi dalam perspektif mutu. Saat ini metode Balanced Scorecard dinilai sebagai model pengukuran mutu yang efektif. Penelitian berjenis kualitatif metode studi kasus dengan model komparatif dan interaktif. Analisis dilakukan terhadap aspek keuangan dan non keuangan. Hasil penelitian menunjukkan efektivitas pelaksanaan program prodi PAI berada pada posisi agresif (maju) dalam menghadapi para kompetitornya. Prodi PAI juga lebih baik dari aspek pengelolaan keuangan dan non-keuangan dibandingkan prodi lain di lingkungan IAIN Kerinci.
Family Planning Village-based Family Education Management
Authors: Asvio Nova , Tamégnon YAOU , Firman Arham Junaidi , Ni’mah Ulfatun 
Published: October 2023

Abstract: The Family Planning Village was launched in 2016 and is used to implement family education to minimize and overcome KKBPK problems. This research explains the management of family education based on Family Planning Village. This research used a qualitative study design which was conducted purposively in 2018. Analysis was done descriptively for qualitative data. The results showed; that the management of family education based on the Family Planning Village includes aspects of conformity criteria for declaration and formation, utilization of family data collection, participation and commitment of local government and across sectors, as well as the form and implementation of family education activities based on the Family Planning Village.
Abstrak: Kampung Keluarga Berencana diluncurkan pada tahun 2016 dan digunakan untuk melaksanakan pendidikan keluarga untuk meminimalkan dan mengatasi masalah KKBPK. Penelitian ini menjelaskan tentang manajemen pendidikan keluarga berbasis kampung KB. Penelitian ini menggunakan desain penelitian kualitatif yang dilakukan secara purposive pada tahun 2018. Analisis dilakukan secara deskriptif untuk data kualitatif. Hasilnya menunjukkan; bahwa penyelenggaraan pendidikan keluarga berbasis kampung KB meliputi aspek kriteria kesesuaian deklarasi dan pembentukan, pemanfaatan pendataan keluarga, partisipasi dan komitmen pemerintah daerah dan lintas sektor, serta bentuk dan pelaksanaan kegiatan pendidikan
The Quality of Leadership: A Model of Merit-Based Culture in East Borneo
Authors: Muadin Akhmad , Akmalia Rizky 
Published: October 2023

Abstract: A successful educational institution depends on effective leadership. To close the achievement gap between high-performing schools and low-performing schools, principals are essential players. The purpose of this study is to identify the principal's leadership position in creating an accomplishment culture at SMA Negeri 1 Anggana. This study's methodology employs a qualitative descriptive paradigm. Data were gathered using observational, documentation, and interview methods. Condensing data, presenting data, and drawing inferences or performing verification are the processes taken during the data analysis stage. The outcomes demonstrated the principal's democratic leadership approach. The outcomes of identifying a leader's style include their personality/example, communication skills, ability to make decisions, and ability to inspire adherents.
Abstak: Kepemimpinan yang efektif akan menjadi penopang dalam keberhasilan suatu lembaga pendidikan. Kepala Sekolah berperan fundamental mengatasi kesenjangan antara sekolah yang berprestasi tinggi dengan sekolah berprestasi rendah. Penelitian ini bertujuan untuk mengetahui peran kepemimpinan kepala sekolah dalam pengembangan budaya berprestasi di SMA Negeri 1 Anggana. Metode dalam penelitian ini menggunakan paradigma kualitatif jenis deskriptif. Data dikumpulkan melalui teknik wawancara, observasi, dan studi dokumentasi. Tahap analisis data dilakukan melalui serangkaian langkah terdiri dari kondensasi data, menyajikan data, dan menarik simpulan atau verifikasi. Hasil penelitian menunjukkan gaya kepemimpinan kepala sekolah identic dengan kepemimpinan demokratis. Hasil identifikasi terhadap gaya kepemimpinan antara lain kepribadian/keteladanan, kemampuan berkomunikasi, kapasitas pengambilan keputusan, dan kemampuan memotivasi bawahan.
The Role of Guidance and Counseling Teacher in Developing Students’ Religious Moderation Behavior at Madrasah
Authors: Ni’mah Ulfatun , Susanti Try , Firman Arham Junaidi , Onia Saifaldin Idris , Asvio Nova 
Published: October 2023

Abstract: Indonesia is currently facing extremism, radicalism, hate speech, and the breakdown of interfaith relations, which require that teachers fulfill their roles in developing students' religious moderation behavior. This study aims to describe the role of Guidance and Counseling teachers in developing students' religious moderation behavior at MAN Bintan. This research is classified as qualitative research when viewed from the aspect of data. The research activity was conducted at MAN Bintan from January to April 2022. The subjects for data collection in this study were Guidance and Counseling teachers. Data collection was performed through interviews, observation, and documentation. Data analysis was carried out by reducing, presenting, and verifying the data. The findings of this study demonstrate that Guidance and Counseling teachers play a central role in the development of students' religious moderation behavior at MAN Bintan, which is reflected in their roles as informants, facilitators, motivators, and mentors.
Abstrak: Bangsa Indonesia sedang menghadapi ekstremisme, radikalisme, ujaran kebencian, hingga retaknya hubungan antarumat beragama sehingga guru dituntut untuk melaksanakan perannya dalam rangka mengembangkan perilaku moderasi beragama siswa. Penelitian ini mempunyai tujuan untuk mendeskripsikan peran guru Bimbingan dan Konseling dalam mengembangkan perilaku moderasi beragama peserta didik di MAN Bintan.Penelitian ini tergolong kepada penelitian kualitatif bila dilihat dari aspek datanya. Kegiatan penelitian ini dilaksanakan di MAN Bintan dari bulan Januari hingga April tahun 2022. Subyek untuk perolehan sumber data dalam penelitian ini ialah guru Bimbingan dan Konseling. Pengumpulan data terlaksana melalui kegiatan wawancara, observasi, dan dokumentasi. Analisis data dilakukan dengan reduksi, display dan verifikasi data. Temuan penelitian ini memperlihatkan bahwa guru Bimbingan dan Konseling memainkan posisi sentral dalam pengembangan perilaku moderasi beragama peserta didik di MAN Bintan yang tercermin dari perannya sebagai informator, fasilitator, motivator, dan pembimbing.
MEMBANGUN TERAS IMPIAN MELALUI KULIAH KERJA NYATA DI DESA SAPTA MULIA
Authors: Habibah Nur , Aldino Aldino , Guswita Reni , Saputra Gusril Ihza 
Published: October 2023

KKN Merupakan salah satu bentuk tridharma yang nyata dilakukan yaitu pengabdian. Melaui kegiatan pengabdian masyarakat ini maka terjadilah sinergi antara masyarakat dan perguruan tinggi. Desa Sapta Mulia yang terletak di kecamatan Tebo Merupakan desa yang cukup luas karena terdiri dari delapan dusun. Berdasarkan data pendidikan terakhir warga desa Sapta Mulia, rata-rata warga desa berpendidikan akhir SD dan SLTP. Rendanhya pendidikan membuat penduduk desa kurang memahami pentingnya pendidikan bagi sebuah kemajuan. Banyaknya penduduk juga didukung dengan banyaknya sarana pendidikan yang ada. Hanya saja belum terdapat bimbingan belajar bagi anak-anak desa sapta mulia diluar sekolah. Pengabdian dilakukan dengan membangun teras impian. Dimana teras impian menghasilkan beberapa kegiatan pendidikan diantaranya; sosialisasi pentingnya pendidikan bagi anak dan pendampingan pembelajaran diluar jam sekolah. Kegiatan ini menghasilakan peningkatan pemahaman bagi warga desa Sapta Mulia tentang pentingnya pendidikan bagi anak dan meningkatnya semangat belajar anak-anak desa Sapta Mulia dari tingkat SD hingga SMP dalam belajar.
How False Social Media Beauty Standards Lead To Body Dysmorphia
Authors: Hafeez Erum , Zulfiqar Fatima 
Published: October 2023

Social media apps, owing to their technological advancements and applications of photo editing tools, have digitalized the female body and in doing so have led to the creation of unrealistic beauty ideals. Social media along with cultural factors created a socio-digital construct in which an attractive and successful woman embodies European features. Repeated exposure to this kind of imagery has made women feel uncomfortable in their bodies. Objectification of young women to such an extent has created an environment where an increasing number of women are suffering from body image issues, such as body dysmorphic disorder. A mental health condition, whereby people utilize most of their time worrying about perceived flaws in their appearance. The excess of this disorder can lead to poor self-esteem, self-harm, depression, and even suicide. It is most common in teens and young adults. This study investigates the patterns of toxic social media trends, how they are being integrated into society and why young women are falling prey to them. The research methodology comprised of a mixed-method approach. It was conducted in two stages: the first half consisted of a Google survey which was shared online with Facebook Female-centric groups besides Instagram and WhatsApp.In the second stage, in-depth interviews of eight women, belonging to different backgrounds offitness trainer, psychologist, feminist writer, model, nutritionist, and three students from the age groups of 18, 21, and 24 were sampled. The reason for opting mixed method was to strengthen the study and enhance its authenticity through in-depth interview analysis.
Impact of Social Capital on Innovation Performance: The Mediating Role of Learning and Strategic Orientations
Authors: Ahsan Nirmal , Hafeez Muhammad Haroon 
Published: October 2023

Taking into consideration the Resource Based View (RBV) Theory and the Social Capital Theory (SCT), this research investigates how the software industry utilizes strategic resources to surpass innovative performance. This study adopted survey questionnaires to gather particulars from 780 mamagers and owners employing in the software industry in Pakistan. The accumulated information was assessed by employing SPSS and structural equation modeling (SEM) to probe designed hypotheses. We uncovered that social capital influences innovative performance. Furthermore, social capital also affects the technological and learning orientation of the software industry. Moreover, technological orientation and learning orientation both mediate the impact of social capital on innovative performance. The crucial beneficence of the research is to enrich and extend the RBV, SCT, and literature regarding innovation in the domain.
Parkinson’s disease and occupational exposure to organic solvents in Finland: a nationwide case-control study
Authors: Sallmén Markku , Burstyn Igor , Uuksulainen Sanni , Koskinen Aki , Hublin Christer , Sainio Markku 
Published: October 2023

OBJECTIVE: This study aimed to investigate the association between Parkinson’s disease (PD) and occupational exposure to organic solvents generally and chlorinated hydrocarbons (CHC) in particular.
METHODS: We assembled a Finland-wide case–control study for birth years 1930–1950 by identifying incident PD cases from the register of Reimbursement of Medical Costs and drawing two controls per case using incidence density sampling from the Population Information System, matched on sex, birth year, and residency in Finland in 1980–2014. Occupation and socioeconomic status (SES) were identified from national censuses. We assessed cumulative occupational exposures via FINJEM job-exposure matrix. Smoking was based on occupation-specific prevalence by sex from national surveys. We estimated confounder-adjusted PD incidence rate ratios (IRR) via logistic regression and evaluated their sensitivity to errors in FINJEM through probabilistic bias analysis (PBA).
RESULTS: Among ever-employed, we identified 17 187 cases (16.0% potentially exposed to CHC) and 35 738 matched controls. Cases were more likely to not smoke and belong to higher SES. Cumulative exposure (CE) to CHC (per 100 ppm-years, 5-year lag) was associated with adjusted IRR 1.235 (95% confidence interval 0.986–1.547), with stronger associations among women and among persons who had more census records. Sensitivity analyses did not reveal notable associations, but stronger effects were seen in the younger birth cohort (1940–1950). PBA produced notably weaker associations, yielding a median IRR 1.097 (95% simulation interval 0.920–1.291) for CHC.
CONCLUSION: Our findings imply that PD is unlikely to be related to typical occupational solvent exposure in Finland, but excess risk cannot be ruled out in some highly exposed occupations.