bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of the innate immune response profile in patients with coronary heart disease at different terms after coronary artery stenting
Authors: Shlyk I. F. , Evsegneeva I. V. , Besedina D. Yu. , Makarchuk I. V. 
Published: February 2024

Atherosclerosis is accompanied by damage to the vascular endothelium of arteries followed by development of inflammatory response and formation of atherosclerotic plaques. Innate immunity is an important component of this response being the earliest non-specific key mechanism. Our objective was to perform a comprehensive assessment of the cellular link of innate immunity, and to compare the results obtained at various terms after coronary stenting.The study involved 50 patients with coronary atherosclerosis (Group 1), who had clinical indications for stenting of coronary arteries, and 20 volunteers (Group 2), who have no signs of coronary artery disease. The study of immune parameters was carried out before surgery, at 4-5, 9-10 and 28-30 days after operation (during early postoperative period), as well as 6 and 12 months after stenting, i.e. over the late post-surgical period. Phenotyping of peripheral blood monocytes and lymphocytes was performed by flow cytometry using monoclonal antibodies (Beckman Coulter, USA). Intracellular content of Granzyme B was carried out with an FC500 flow laser cytofluorimeter. Metabolic activity of neutrophils was assessed by the NBT test. Alpha defensin was determined in blood plasma by ELISA technique (Hycult Biotech, USA). Statistical analysis was performed using the Statistica 12.0 program (StatSoft, USA). Statistical significance was considered significant at p ≤ 0.05.The numbers of natural killer cells and their activity, as well as those of monocytes, were increased in patients with coronary atherosclerosis. We have also shown a suppression of antigen presentation processes, an imbalance in microbicidal activity of neutrophils, with predominant secretion of antimicrobial peptides. Over the early post-surgical period, significant changes included only decreased content of intracellular Granzyme B on days 4-5, and expression of TLR4 and HLA-DR on days 4-5 and 9-10. During the late period, the patients with coronary artery disease exhibited a significant decrease in the content of some lymphocyte subsets: CD3+CD16+, CD16+Gr+ as well as amounts of monocytes: CD14+CD282+, CD14+CD284+, CD14+CD289+, along with HBT-test activity and α-defensin contents, and increased numbers of HLA-DR-expressing monocytes.There are changes in cellular component of innate immunity, indicating persistent inflammation in patients with coronary heart disease. The dynamics of revealed changes following coronary artery stenting may reflect a lability of assessed indicators mostly over the late postoperative period, thus serving a basis for predicting the outcome of coronary stenting.
Polymorphism of proinflammatory inerleukin genes in primary open-angle glaucoma
Authors: Barycheva L. Yu. , Kakulia D. M. , Minasyan M. M. , Kuznecova V. V. , Kozmova N. A. 
Published: February 2024

Glaucoma is a degenerative disease of the optic nerve, accompanied by the death of retinal ganglion cells (RGCs) and loss of vision. An important role in the pathogenesis of glaucoma is ascribed to activated microglia, which produce pro-inflammatory interleukins and initiate GCS apoptosis. It has been established that single nucleotide polymorphisms of interleukin genes modify the development of neuroinflammation, but their effect on the risk of developing glaucoma is not yet fully established. Our aim was to determine the pathogenetic role of gene polymorphisms in TNFα and IL1β in the development of primary open-angle glaucoma.We have observed 56 patients of Russian nationality from the South of Russia with primary open-angle glaucoma (POAG), 28 patients with stage I, 16 with stage II, 12 with stage III POAG. The single nucleotide polymorphisms TNFα 308G>A (rs1800629) and IL1β -31 Т>С (rs1143627) were studied by restriction fragment analysis of PCR products. The level of pro-inflammatory cytokines (TNFα and IL1β) in the lacrimal fluid of patients with POAG was evaluated by enzyme-linked immunosorbent assay (Vector-Best test system). To perform optical coherence tomography by analysing the thickness of retinal nerve fiber layer (RNFL) with volume and area of the neuroretinal rim using Torson 3D OST 1000 apparatus.Results: in patients with POAG, we have found more common incidence of TNFα 308A (OR = 5.21, p = 0.001), and IL1β-31 T alleles (OR = 1.99, p = 0.04). An increased risk of developing POAG was found in carriers of genotypes 308A/A (OR = 6.30, p = 0.049), 308G/A (OR = 3.60, p = 0.049) and -31T/T (OR = 2.67, p = 0.04). The highest levels of TNFα were determined in the 308A/A group (190 (153.0-220.0) pg/mL), IL1β were in the group (-31) T/T – 6.50 (4.10-7.00) pg/mL. A decreased thickness of the retinal nerve fibers was observed in the patients with TNFα G308A genotype (59.5; 40.0 to 78.0 µm, p = 0.03), and in TNFα A308A carriers (79.0; 65.0 to 80.0 µm, p = 0.001).The TNFα 308 G/A (rs1800629), along with IL1β, -31Т/C (rs1143627) cytokine gene polymorphisms are associated with development of primary open-angle glaucoma. TNFα 308A, IL1β -31T alleles, as well as the 308G/A, 308A/A and -31T/T genotypes seem to be the risk factors for POAG in Russian population. High content of TNFα in the lacrimal fluid was found in the carriers of 308A/A genotype and -31T/T IL1β genotype. The lowest thickness of the retinal nerve fiber layer was observed in the carriers of tTNFα A308A and TNFα G308A genotypes.
Potential targets of heparin during progression and metastasis of malignant neoplasms
Authors: Malashchenko V. V. , Khlusov I. A. , Yurova K. A. , Khaziakhmatova O. G. , Todosenko N. M. , Litvinova L. S. 
Published: February 2024

In the modern world, oncological diseases occupy the leading positions in the structure of mortality. An integrated approach to oncotherapy is not only aimed at immediate affection of malignant tumors, but also directed at reducing the risk of tumor recurrence and metastasis, as well as alleviating side effects of chemotherapy and radiotherapy of the disease. In oncologic disorders, blood viscosity increases, thus being associated with hypercoagulation syndrome. To prevent its consequences, the direct and indirect anticoagulants, especially heparin and its derivatives, are actively used. Biological functions and structural features of heparin make it a potential universal platform of a drug development for broad application, including oncology. With the advent of heparin fractionation technology and preparation of low-molecular weight forms and their derivatives, it has become possible to focus not only on anticoagulant activity but also to obtain fractions with targeted pharmacological activity. Usage of the anticoagulants has shown their antitumor activity in some cases, thus providing a basis for a more detailed study of pharmacotherapeutic effects of this group of drugs. Currently, some data suggest various pathways of interaction between heparin and tumor cells. There are multiple common features in development of a primary tumor and formation of secondary distant metastases, which may be attributed to similar molecular cellular mechanisms. The molecules mediating intercellular interactions, both between the tumor cells and between malignant cells and tumor-associated immune cells (e.g., lymphocytes and macrophages) may serve as targets for heparin thus helping the tumor to evade immune surveillance. The cytokines that stimulate tumor angiogenesis represent another important therapeutic target. Heparin derivatives are able to suppress tumor activity and prevent metastatic processes at various stages by inhibiting heparanase, P-/L-selectin, and angiogenesis activity, modulating the CXCL12-CXCR4 chemokine axis, and regulating OAM activity.This brief review addresses the current understanding and application of the potentially antimetastatic properties of heparin and its derivatives in malignant bone tumors since the heparin-based drugs are used as anticoagulants in arthroplasty of large joints and bone defects in patients with osteosarcoma.
Preservation of Gastronomic Heritage ''Brongkos Kambing'' in Nglipar Gunung Kidul District, Yogyakarta
Authors: Karni Karni , Larasaati Arinta Destri , Astuti Yuli , Turgarini Dewi 
Published: February 2024

Yogyakarta is cultural heritage tourism destination in Indonesia. There are many traditional food as part of gastronomic tourism heritage was not being known by tourist. There is research gap was found to developing Goat Brongkos such as the lack of Goat Brongkos producers who are concerned about the Brongkos Kambing business, Limited market coverage, Business management is still conventional. This research conduct to developing tourist attraction while preserving culture based on traditional which is existed in Gunung (Mount) Kidul. Based on preliminary survey, there is finding that Brongkos Kambing is a typical food of Nglipar Regency that needs to be preserved because it is authentic food taste, easy processing, and ask-to-find ingredients. Also the taste is very authentic, distinctive flavor with a dominant sweet, and savory. The method using descriptive analytic approach using gastronomic tourism component, and also deep interviewed to nine stakeholders (nona helix). There is a result that Brongkos Kambing has the value of philosophy, history. The raw material was can be found in local area, the process is interesting because first the spices were only mixed into the pot to the boiling goat bones or in the local language brongkos. The taste and serving experience have educational, nutrition and ethic value. This food has the potential to be developed as comprehensive tour package and become a gastronomic tourism attraction.
Assessment of quality of life among antenatal women with gestational diabetes mellitus
Authors: Malik Renu , Roy Susha Mary 
Published: February 2024

Background: Pregnancy is challenging for every woman and if it is complicated with conditions like gestational diabetes mellitus (GDM), it may reduce her quality of life (QoL) significantly which increases the potential risks related to the physical and psychological health aspects related to the mother as well as for the baby thus causing a negative impact on her overall health and wellbeing. Hence, it should be given more importance by healthcare professionals.
Methods: The study design adopted to assess the QoL of antenatal women with GDM was a cross-sectional research design.110 antenatal women with GDM attending antenatal OPD at selected hospitals in Bengaluru were chosen using a Non-probability convenient sampling technique. A standardized GDM questionnaire (GDMQ-36) was used to assess QoL and the data analysis was done using descriptive and inferential statistics techniques. The study was conducted from July 2022 to August 2023.
Results: The study results were as follows, 74.5% of antenatal women with GDM had a moderate level of QoL, 25.5% had a high level of QoL and no antenatal women was found to have low level of QoL. 60% of antenatal women had high level of QoL in support domain and 25.5% of the antenatal women had low level of QoL in complications of GDM domains. A significant association was found between QoL and selected socio-demographic variables.
Conclusions: The present Study concluded that the majority of the antenatal women (74.5%), had moderate levels of QoL and a significant association was found between QoL and socio-demographic variables.
Phytochemical and Cytotoxic Properties of Gum and Leaf Extracts of Ferula assafoetida in Breast Cancer
Authors: Alireza Moulazadeh , Razieh Ranjbar , Amin Dakhili Ardestani , Kamran Ranjbar , Amin Kouhpayeh Seyed , Maryam Maghbool , Sohrab Najafipour , Fatemeh Najafipour 
Published: February 2024

Background & Objectives: Breast cancer, a significant threat to women's health, is associated with a high annual mortality rate. Oxidative stress, characterized by the accumulation of reactive oxygen species, plays a pivotal role in cancer development. Ferula assafoetida, a traditional medicinal plant, has been widely used in cancer treatment. This study aims to compare the cytotoxic effects, phytochemical profiles, and antioxidant activities of Ferula assafoetida gum (FAGE) and leaf (FALE) extracts.
Materials & Methods: The herbal extracts from FAGE and FALE were prepared using the maceration method in 70% v/v ethanol. The phenolic content and radical scavenging activity of the extracts were assessed using the Folin-Ciocalteu and diphenylpicrylhydrazyl (DPPH) assays, respectively. The cytotoxic effects of the extracts were examined on the MDA-MB-231 and MCF-7 cell lines through the MTT assay. Additionally, the morphological changes of the cell lines were observed using an inverted microscope.

Results: The phenolic content in FAGE (142.25± 19.35 µgGAE/mg) was significantly higher (P=0.01) than that in FALE (48.15± 3.01 µgGAE/mg). Additionally, the radical scavenging activity and cytotoxic effects of FAGE were also significantly stronger than those of FALE (P< 0.05). Regarding the cytotoxic effects of the extracts, FAGE exhibited IC50 values of 80.59± 10.98 and 59.39± 15.89 µg/mL for MCF-7 and MDA-MB-231 cells, respectively, after 72 hours of incubation.
Conclusions: FAGE exhibited a greater cytotoxic effect on the MDA-MB-231 cell line than on the MCF-7, possibly following an estrogen-independent pattern. It appears that FAGE holds significant potential in refining oxidative stress, thereby inhibiting cell proliferation.
The Sacroiliac Joint
Authors: Polly David W. 
Published: February 2024

» The sacroiliac joint (SIJ) is a common cause of low back pain and should be included in the differential diagnosis.» Nonoperative treatment of sacroiliac pain is always the first line of therapy; however, when it is unsuccessful and becomes chronic, then recurrent nonoperative treatment becomes expensive.» Surgical treatment is cost-effective in appropriately selected patients. High-quality clinical trials have demonstrated statistically and clinically significant improvement compared with nonsurgical management in appropriately selected patients.» Spinal fusion to the sacrum increases degeneration of the SIJ and frequency of SIJ pain.
Numerical Study on Characteristics of Stick-Slip Instability of Coal-Rock Parting-Coal Structure under Lateral Unloading
Authors: Zhang Heng , Liu Guang-Jian , Ji Xian-Jun , Cao Wen-Hao , Zhu Ya-Wei , Bacha Sher 
Published: February 2024

Abstract
Unloading excavation can increase the possibility of rock burst, especially for coal seam with rock parting. In order to explore the evolution process of rock burst under lateral unloading, the combination of in situ measures and numerical experiments is used to study. The following four points were addressed: (1) the coal seam with rock parting easily causes the stick-slip and instability along the interface, and the process of stick-slip and instability has hysteresis characteristics; (2) the greater the degree of unloading or the smaller the interface friction angle of the Coal-Rock Parting-Coal Structure (CRCS), the more likely it is for stick-slip and instability to occur; (3) the abnormal increase of shear stress and slip dissipation energy can be used as the precursory information of the stick-slip and instability of CRCS; (4) the damage intensity of rock burst induced by stick-slip and instability of CRCS can be reduced by reducing the unloading speed or increasing the roughness of interface. The research results can be used for early warning and controlling of dynamic disaster induced by stick-slip instability in coal seam with rock parking.
Implementasi Profil Pelajar Pancasila dalam Membentuk Karakter Peserta Didik Sekolah Dasar
Authors: Dewi Rulynda Tiara , Ardhyantama Vit , Khalawi Hasan 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui: (1) implementasi Profil Pelajar Pancasila dalam membentuk karakter peserta didik sekolah dasar, (2) faktor pendukung implementasi Profil Pelajar Pancasila, (3) faktor penghambat implementasi Profil Pelajar Pancasila. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan model Miles dan Huberman. Hasil menunjukan bahwa: (1) Implementasi Profil Implementasi Profil Pelajar Pancasila dalam membentuk karakter peserta didik SD Negeri 2 Baleharjo dilaksanakan secara menyeluruh mulai dari kegiatan pembelajaran, pembiasaan, ekstrakurikuler, dan kokurikuler yang menjadikan siswa memiliki karakter sesuai dengan nilai-nilai Pancasila. (2) Faktor pendukung implementasi Profil Pelajar Pancasila yaitu sarana dan prasarana yang baik, terdapat tenaga pengajar yang mengikuti program guru penggerak dan kondisi lingkungan belajar yang nyaman dan kondusif. (3) faktor penghambat implementasi Profil Pelajar Pancasila yaitu keterbatasan guru dalam menyusun RPP, keterbatasan guru dalam menggunakan media IT serta sumber belajar yang bervariasi, dan menurunya minat belajar siswa.
Penerapan Model POE Berbantuan Media Realia untuk Meningkatkan Kemampuan Berpikir Kreatif Siswa
Authors: Safitri Islamiati , Sulistri Emi , Prihatiningtyas Nindy Citroresmi 
Published: February 2024

Penelitian ini bertujuan untuk:1) untuk mengetahui peningkatan kemampuan berpikir kreatif siswa setelah diterapkan model POE berbantuan media realia pada materi gaya; 2) untuk mengetahui keterlaksanaan penerapan model pembelajaran POE berbantuan media realia pada materi gaya. Penelitian yang digunakan adalah penelitian kuantitatif dengan desain One Grup Pre Test Post Test. Populasi dalam penelitian ini adalah siswa kelas IV SDN 09 Semelagi. Sampel penelitian diambil secara purposive sampling. Analisis tes kemampuan berpikir kreatif rumusan pertama menggunakan persamaan N-gain ternormalisasi dan untuk rumusan kedua menggunakan perhitungan persentase keterlaksanaan model. Hasil penelitian menunjukkan bahwa: 1) dari hasil perhitungan rata-rata N-gain kemampuan berpikir kreatif siswa sebesar 0,6 yang berada pada kategori sedang, artinya model pembelajaran POE berbantuan media realia dapat meningkatkan kemampuan berpikir kreatif siswa setelah diterapkannya model pembelajaran POE berbantuan media realia pada materi gaya; 2) perhitungan rata-rata keterlaksanaan sebesar 88% dengan kriteria sangat baik, artinya model pembelajaran POE berbantuan media realia terlaksana dengan sangat baik pada materi gaya di kelas IV SDN 09 Semelagi.
Fractal and Multifractal Characteristics on Pore Structure of Coal-Based Sedimentary Rocks Using Nuclear Magnetic Resonance
Authors: Zhang Na , Guo Shuhui , Wang Shuaidong , Tong Yizhuo , Li Zheng , Wu Jiaqi 
Published: February 2024

Summary
Unconventional reservoirs have nanoscale pores, complex pore structures, and heterogeneity that directly affect reservoir storage performance and fluid transport capacity. In this study, shale, mudstone, and sandstone, three typical coal sedimentary rocks from the Daqiang coal mine in the Tifa Basin, were selected for nuclear magnetic resonance (NMR) and scanning electron microscopy (SEM) investigation, with the aim to investigate the pore structure and multifractal characteristics of the coal sedimentary reservoirs and to qualitatively analyze the effects of the physical property parameters and the mineralogical compositions on the multifractal parameters. The distribution data of the NMR T2 spectra were analyzed. The results showed that (1) SEM analysis concluded that the pore system of the three different lithological samples (mudstone, shale, and sandstone) was dominated by mineral matrix pores (i.e., intergranular and intragranular pores) and in the sandstone samples, there were only a few biological pores found. (2) The distribution of the NMR T2 spectrum peaks indicates that the sandstone and shale T2 spectra are bimodal, dominated by micropores, and contain a small number of transitional pores; most of the T2 spectra of mudstone are single peaks in distribution, mainly dominated by micropores. (3) Multifractal parameters are positively correlated with porosity and significantly negatively correlated with permeability; multifractal parameters are significantly positively correlated with the content of clay minerals and kaolinite, which suggests that the increase in clay minerals and kaolinite content enhances the heterogeneity of the pore space. The negative correlation with the content of quartz suggests that the enrichment of quartz reduces the irregularity of the pore space.
Professionally phubbed: a mixed-method experiment measuring the effects of phone snubbing behaviour during a job interview
Authors: Ochs Carli , Jaunin Astride , Kosnowski Nathalie , Sauer Juergen 
Published: February 2024

Abstract
Phubbing (i.e. ignoring someone while using a phone) may occur at work, having an impact on the phubbee, the phubber and the organization at large. We used a mixed method experiment to examine the impact of phubbing on different work-related variables such as objective performance, extra-role behaviour, subjective states, and first impression judgements during job interviews. Ninety-three participants took part in a simulated job interview based on the Trier Social Stress Test. In the experimental group, participants were repeatedly phubbed during both the interview and a subsequent performance test. At the end of the experiment, phubbed participants were asked to describe their experience and thematic analysis was used to evaluate their responses. Overall, results of the quantitative analysis revealed that first impressions, judgements and subjective states were negatively affected by phubbing. Regarding performance, a within-session analysis revealed that participants performed faster on a performance test (mental arithmetic task) when they were not phubbed compared to when they were phubbed. No effect of phubbing was found on extra-role behaviour. A qualitative analysis of responses revealed considerable differences between interviewees in their use of coping strategies (e.g., rationalization of phubbing). These findings suggest the need to address phubbing at the workplace.