bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiopulmonary exercise test combined with red blood cell distribution width to predict cardiovascular complication of thoracic surgery
Authors: Lin Quanqiang , Zhao Qingheng , Xiao Qiang , Li Yuanmin 
Published: February 2024

AbstractCardiovascular complications in patients undergoing thoracic surgery, which physicians have a limited ability to predict, are often unavoidable and resulting in adverse outcome. Cardiopulmonary exercise testing (CPET), the gold standard of cardiopulmonary function evaluation, has also been proved to be a preoperative risk assessment tool. Meanwhile, elevated red blood cell distribution width (RDW) has surged as a biochemical marker in the occurrence of cardiovascular disease. However, it is yet unclear the value of CPET combined with RDW in predicting cardiovascular complications after thoracic surgery. 50 patients with cardiovascular complications after thoracic surgery were collected as the case group, and 100 thoracic surgery patients were recruited as the control group, with the same gender, age ± 2 years old, and no postoperative complications. After admission, all patients underwent CPET and RDW inspection before surgery, and the results were recorded. The CPET parameter oxygen pulse (VO2/HR) and RDW of the case group were lower than those of the control group (P < 0.05), and the ventilation/carbon dioxide production (VE/VCO2 slope) was significantly higher than control group (P < 0.01). The biochemical parameters hemoglobin (Hb) and Glomerular filtration rate (GFR)) of the case group were lower than those of the control group (P < 0.05), the homocysteine (hCY), creatinine (Cr), operation time and blood loss of the case group were higher than those of the control group (P < 0.05). The RDW had a negative correlation with VO2 max in both overall and control group. The combination of VO2/kg and RDW had the highest diagnostic value in predicting cardiovascular complications. The combination of VO2/kg and RDW has predictive diagnostic value and is more suitable for predicting postoperative complications of thoracic surgery.
Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy
Authors: Kuo Pin-Yan , Tsai Hsin-Hsi , Lee Bo-Ching , Chiang Pu-Tien , Liu Chia-Ju , Chen Ya-Fang , Jeng Jiann-Shing , Yen Ruoh-Fang , Tsai Li-Kai 
Published: February 2024

AbstractLobar cerebral microbleeds are a characteristic neuroimaging finding in cerebral amyloid angiopathy (CAA) but can also be found in hypertensive arteriolosclerosis. We aimed to investigate whether CAA is more associated with intracortical lobar microbleeds than hypertensive arteriosclerosis. Ninety-one survivors of spontaneous intracerebral hemorrhage with at least one lobar microbleed were included and underwent brain MRI and amyloid PET. We categorized lobar microbleeds as intracortical, juxtacortical, or subcortical. We assessed the associations between the lobar microbleed categories and microangiopathy subtypes or cerebral amyloid load based on the Pittsburgh Compound-B PET standardized uptake value ratio (SUVR). Patients with CAA had a higher prevalence of intracortical lobar microbleeds (80.0% vs. 50.8%, P = 0.011) and lower prevalence of subcortical lobar microbleeds (13.3% vs. 60.1%, P < 0.001) than patients with hypertensive arteriolosclerosis. Strictly intracortical/juxtacortical lobar microbleeds were associated with CAA (OR 18.9 [1.9–191.4], P = 0.013), while the presence of subcortical lobar microbleeds was associated with hypertensive arteriolosclerosis (OR 10.9 [1.8–68.1], P = 0.010). Amyloid retention was higher in patients with strictly intracortical/juxtacortical CMBs than those without (SUVR = 1.15 [1.05–1.52] vs. 1.08 [1.02–1.19], P = 0.039). Amyloid retention positively correlated with the number of intracortical lobar microbleeds (P < 0.001) and negatively correlated with the number of subcortical lobar microbleeds (P = 0.018). CAA and cortical amyloid deposition are more strongly associated with strictly intracortical/juxtacortical microbleeds than subcortical lobar microbleeds. Categorization of lobar microbleeds based on anatomical location may help differentiate the underlying microangiopathy and potentially improve the accuracy of current neuroimaging criteria for cerebral small vessel disease.
New reference genomes to distinguish the sympatric malaria parasites, Plasmodium ovale curtisi and Plasmodium ovale wallikeri
Authors: Higgins Matthew , Manko Emilia , Ward Daniel , Phelan Jody E. , Nolder Debbie , Sutherland Colin J. , Clark Taane G. , Campino Susana 
Published: February 2024

AbstractDespite Plasmodium ovale curtisi (Poc) and wallikeri (Pow) being important human-infecting malaria parasites that are widespread across Africa and Asia, little is known about their genome diversity. Morphologically identical, Poc and Pow are indistinguishable and commonly misidentified. Recent rises in the incidence of Poc/Pow infections have renewed efforts to address fundamental knowledge gaps in their biology, and to develop diagnostic tools to understand their epidemiological dynamics and malaria burden. A major roadblock has been the incompleteness of available reference assemblies (PocGH01, PowCR01; ~ 33.5 Mbp). Here, we applied multiple sequencing platforms and advanced bioinformatics tools to generate new reference genomes, Poc221 (South Sudan; 36.0 Mbp) and Pow222 (Nigeria; 34.3 Mbp), with improved nuclear genome contiguity (> 4.2 Mbp), annotation and completeness (> 99% Plasmodium spp., single copy orthologs). Subsequent sequencing of 6 Poc and 15 Pow isolates from Africa revealed a total of 22,517 and 43,855 high-quality core genome SNPs, respectively. Genome-wide levels of nucleotide diversity were determined to be 2.98 × 10–4 (Poc) and 3.43 × 10–4 (Pow), comparable to estimates for other Plasmodium species. Overall, the new reference genomes provide a robust foundation for dissecting the biology of Poc/Pow, their population structure and evolution, and will contribute to uncovering the recombination barrier separating these species.
Optimizing jet pump efficiency via drag reducing polymers and enhanced efficiency definitions
Authors: AlSarkhi Abdelsalam , Kassar Abdulelah , Sahu Qasim , Gajbhiye Rahul 
Published: February 2024

AbstractLiquid jet pumps are widely used in various industrial applications for fluid mixing, circulation, and transport. The efficiency and performance of liquid jet pumps play a crucial role in determining their overall effectiveness and economic viability. The performance of liquid jet pumps is primarily affected by parameters such as motive fluid pressure, nozzle design, and entrainment ratio. Liquid jet pumps exhibit a notable drawback in terms of comparatively lower efficiency when compared to alternative pump types. The reduced overall efficiency of liquid jet pumps stems primarily from energy dissipation incurred during the entrainment process. To address this obstacle, a water-water loop system was implemented in conjunction with a liquid jet pump, followed by the introduction of drag-reducing polymers (DRPs) into the suction flow of the liquid jet pump using a specific configuration. This configuration led to a significant reduction in drag within the liquid jet pump, raising its efficiency in some cases from 13.8% to 26.7% with a drag reduction of 46%, subsequently improving its overall performance. The resulting enhancement was evaluated using various efficiency models documented in the existing literature to comprehensively assess the overall performance of the liquid jet pump. A new interpretation of jet pump efficiency has been shared, along with a comparison of the various efficiencies.
A possibility to infer frustrations of supported catalytic clusters from macro-scale observations
Authors: Korobov Alexander 
Published: February 2024

AbstractRecent experimental and theoretical studies suggest that dynamic active centres of supported heterogeneous catalysts may, under certain conditions, be frustrated. Such out-of-equilibrium materials are expected to possess unique catalytic properties and also higher level of functionality. The latter is associated with the navigation through the free energy landscapes with energetically close local minima. The lack of common approaches to the study of out-of-equilibrium materials motivates the search for specific ones. This paper suggests a way to infer some valuable information from the interplay between the intensity of reagent supply and regularities of product formation.
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
Authors: Andronikou Christina , Burdova Kamila , Dibitetto Diego , Lieftink Cor , Malzer Elke , Kuiken Hendrik J , Gogola Ewa , Ray Chaudhuri Arnab , Beijersbergen Roderick L , Hanzlikova Hana , Jonkers Jos , Rottenberg Sven 
Published: February 2024

AbstractTargeting poly(ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic approach to treat various cancer types, but we have a poor understanding of the specific genetic vulnerabilities that would make cancer cells susceptible to such a tailored therapy. Moreover, the identification of such vulnerabilities is of interest for targeting BRCA2;p53-deficient tumors that have acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) through loss of PARG expression. Here, by performing whole-genome CRISPR/Cas9 drop-out screens, we identify various genes involved in DNA repair to be essential for the survival of PARG;BRCA2;p53-deficient cells. In particular, our findings reveal EXO1 and FEN1 as major synthetic lethal interactors of PARG loss. We provide evidence for compromised replication fork progression, DNA single-strand break repair, and Okazaki fragment processing in PARG;BRCA2;p53-deficient cells, alterations that exacerbate the effects of EXO1/FEN1 inhibition and become lethal in this context. Since this sensitivity is dependent on BRCA2 defects, we propose to target EXO1/FEN1 in PARPi-resistant tumors that have lost PARG activity. Moreover, EXO1/FEN1 targeting may be a useful strategy for enhancing the effect of PARG inhibitors in homologous recombination-deficient tumors.
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors
Authors: Santofimia-Castaño Patricia , Fraunhoffer Nicolas , Liu Xi , Bessone Ivan Fernandez , di Magliano Marina Pasca , Audebert Stephane , Camoin Luc , Estaras Matias , Brenière Manon , Modesti Mauro , Lomberk Gwen , Urrutia Raul , Soubeyran Philippe , Neira Jose Luis , Iovanna Juan 
Published: February 2024

AbstractWe find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancreatic cancer cells since genetic or pharmacological inhibition by ZZW-115 of NUPR1 activity impeded SGs formation. The KrasG12D mutation induced oncogenic stress, NUPR1 overexpression, and promoted SGs development. Notably, enforced NUPR1 expression induced SGs formation independently of mutated KrasG12D. Mechanistically, KrasG12D expression strengthened sensitivity to NUPR1 inactivation, inducing cell death, activating caspase 3 and releasing LDH. Remarkably, ZZW-115-mediated SG-formation inhibition hampered the development of pancreatic intraepithelial neoplasia (PanINs) in Pdx1-cre;LSL-KrasG12D (KC) mice. ZZW-115-treatment of KC mice triggered caspase 3 activation, DNA fragmentation, and formation of the apoptotic bodies, leading to cell death, specifically in KrasG12D-expressing cells. We further demonstrated that, in developed PanINs, short-term ZZW-115 treatment prevented NUPR1-associated SGs presence. Lastly, a four-week ZZW-115 treatment significantly reduced the number and size of PanINs in KC mice. This study proposes that targeting NUPR1-dependent SGs formation could be a therapeutic approach to induce cell death in KrasG12D-dependent tumors.
A tetrahedron-shaped polyoxoantimotungstate encapsulating a hexanuclear octahedral lanthanide-oxo cluster for an amperometric bromate sensor
Authors: Yu Lan , Ye Jing , Li Da-Huan , Sun Yan-Qiong , Li Xin-Xiong , Zheng Shou-Tian 
Published: February 2024

An inorganic antimotungstate 1 is constructed from tetrahedron-shaped two-shell {Nd6(OH)6(H2O)6(B-α-SbW9O33)4} polyanions. Compound 1 exhibits electrochemical activity for the reduction of BrO3− with good selectivity, high sensitivity and low detection limit.
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys
Authors: Dissanayake Lashodya V. , Kravtsova Olha , Lowe Melissa , McCrorey Marice K. , Van Beusecum Justin P. , Palygin Oleg , Staruschenko Alexander 
Published: February 2024

Abstract
The development of the kidney involves essential cellular processes, such as cell proliferation and differentiation, which are led by interactions between multiple signaling pathways. Xanthine dehydrogenase (XDH) catalyzes the reaction producing uric acid in the purine catabolism, which plays a multifaceted role in cellular metabolism. Our previous study revealed that the genetic ablation of the Xdh gene in rats leads to smaller kidneys, kidney damage, decline of renal functions, and failure to thrive. Rats, unlike humans, continue their kidney development postnatally. Therefore, we explored whether XDH plays a critical role in kidney development using SSXdh-/- rats during postnatal development phase. XDH expression was significantly increased from postnatal day 5 to 15 in wild-type but not homozygote rat kidneys. The transcriptomic profile of renal tissue revealed several dysregulated pathways due to the lack of Xdh expression with the remodeling in inflammasome, purinergic signaling, and redox homeostasis. Further analysis suggested that lack of Xdh affects kidney development, likely via dysregulation of epidermal growth factor and its downstream STAT3 signaling. The present study showed that Xdh is essential for kidney maturation. Our data, alongside the previous research, suggests that loss of Xdh function leads to developmental issues, rendering them vulnerable to kidney diseases in adulthood.
Abdominal Wall Hernias Following High-intensity Focused Ultrasound Therapy: Three Case Reports
Authors: Han Woo Yeon , Kim Yeongsong , Kim Pyeong Hwa , Kim Eun Key 
Published: February 2024

AbstractAlthough many studies reported the safety and efficacy of high-intensity focused ultrasound (HIFU) therapy, there are still worries about internal organ injury. However, reports of abdominal wall hernias after HIFU therapy are rare.We present three cases of abdominal wall hernias without skin injury after HIFU therapy in uterine adenomyosis or fibroids. The diagnosis was often delayed because of vague symptoms, inadequate clinical suspicion, and delayed proper image studies.Abdominal wall hernia should be recognized as a possible complication after HIFU and be suspected when the patient presents with unordinary abdominal swelling and/or pain that lasts for more than a few months after the procedure.
Racial Differences in Bleeding Risk: An Ecological Epidemiological Study Comparing Korea and United Kingdom Subjects
Authors: Kang Dong-Seon , Yang Pil-Sung , Kim Daehoon , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Sung Jung Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Lip Gregory Y.H. , Joung Boyoung 
Published: February 2024

Background This study aimed to evaluate racial differences in bleeding incidence by conducting an ecological epidemiological study using data from Korea and the United Kingdom.
Methods We included healthy participants from the Korean National Health Insurance Service-Health Screening and the UK Biobank who underwent health examinations between 2006 and 2010 and had no comorbidities or history of medication use. Finally, 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44.7% men, mean age 55.0 years) were analyzed. The primary outcome was composed of intracranial hemorrhage (ICH) and bleeding from the gastrointestinal, respiratory, and genitourinary systems.
Results During the follow-up, primary outcome events occurred in 2,110 East Asians and in 6,515 Caucasians. East Asians had a 38% lower 5-year incidence rate compared with Caucasians (3.88 vs. 6.29 per 1,000 person-years; incidence rate ratio [IRR]: 0.62, 95% confidence interval [CI]: 0.59–0.65). East Asians showed a lower incidence of major bleeding (IRR: 0.86, 95% CI: 0.81–0.91), bleeding from the gastrointestinal (IRR: 0.53, 95% CI: 0.49–0.56), and genitourinary systems (IRR: 0.49, 95% CI: 0.44–0.53) compared with Caucasians. The incidence rates of ICH (IRR: 3.20, 95% CI: 2.67–3.84) and bleeding from the respiratory system (IRR: 1.28, 95% CI: 1.11–1.47) were higher in East Asians. Notably, East Asians consuming alcohol ≥3 times/week showed a higher incidence of the primary outcome than Caucasians (IRR: 1.12, 95% CI: 1.01–1.25).
Conclusion This ecological study revealed significant racial differences in bleeding incidence, influenced by anatomical sites and lifestyle habits, underscoring the need for tailored approaches in bleeding management based on race.
See who I know! Addressing the liabilities of outsidership through status signaling
Authors: Carney Michael , Dieleman Marleen 
Published: February 2024

AbstractStatus is an important intangible asset, yet when firms enter new countries, they lack standing in new social hierarchies as outsiders. Conventional wisdom suggests embeddedness in host-country networks can alleviate newcomers’ liability of outsidership. We complement this with insights from status signaling theory: Newcomers in host countries can address their liability of outsidership through the visual display of social affiliations. We utilize a novel visual qualitative research approach that analyzes annual report photographs of an emerging-market family business, depicting the firm’s leaders with high-status alters. Complementing the international business literature, which emphasizes strong ties to host-country business partners, we identify three signaling mechanisms that are more circuitous: bypass (host-country affiliations beyond the firm’s industry), allusion (global affiliations beyond the host country and industry, often celebrities), and aspiration (global industry affiliations). We also suggest that such diffuse status signaling mechanisms may be especially salient in emerging-market family firms investing in developed markets, which are accorded low status in many developed markets. These firms feature firm/owner identity overlaps, long leader tenures, and a tendency to build reputation through prosocial behavior, facilitating the activation of status signaling tactics through ephemeral affiliations with high-status actors situated in world society.
Piezoelectricity of lead-free hybrid perovskite monolayer (ATHP)2XY4 (X = Ge, Sn; Y = Cl, Br, I): Cross-scale calculation and simulation
Authors: Qiu Jian , Li Dongling , Wen Quan 
Published: February 2024

Two-dimensional (2D) piezoelectric material is the core part of all kinds of micro-piezoelectric devices (piezoelectric energy harvesters, piezoelectric sensors, etc.). Based on the first principle, this paper theoretically predicts a kind of organic–inorganic lead-free hybrid perovskite monolayer (ATHP)2XY4 (X = Ge, Sn; Y = Cl, Br, I) with a large out-of-plane piezoelectric coefficient (d31). Combined with the finite element simulation, it shows excellent performance in the piezoelectric energy harvester. Through the first-principles theoretical calculation, the density, elastic tensor, piezoelectric stress tensor, and dielectric coefficient of the (ATHP)2XY4 monolayer can be obtained. The thermodynamic stability and mechanical stability of the materials are judged by ab initio molecular dynamics and stress–strain relationship analysis, respectively. The piezoelectric coefficient of the material is calculated, in which the d31 of (ATHP)2SnBr4 is the largest (d31 = 35.04 pm/V), which is still 7 times that of the bulk AlN and at least one order of magnitude larger than that of other 2D materials. The finite element simulation results of a simple piezoelectric beam show that the voltage output of the piezoelectric beam reaches 27.79 V. Our research shows that lead-free hybrid perovskite monolayer (ATHP)2XY4 has strong competitiveness in the application of environment-friendly and bio-friendly micro-piezoelectric devices. In addition, the cross-scale simulation method from the first principles to the finite element method is of great significance for the optimization of micro-piezoelectric devices.
A secure SoC architecture design with dual DMA controllers
Authors: Wang Wei , He Cong , Shi Jiaqi 
Published: February 2024

With the continuous advancement of System-on-Chip (SoC) technologies, the burgeoning data volumes emphasize the paramount importance of safeguarding data security and integrity. In this study, by leveraging Ascon in conjunction with enhancements to the SHA-1 algorithm, two secure Direct Memory Access (DMA) controllers are designed to facilitate data encryption and comparison, respectively, culminating in the proposal of an SoC architecture featuring dual DMA controllers. Simulation outcomes demonstrate the system’s ability to achieve a maximum clock frequency of 120 MHz, offering a throughput rate of up to 3.2 GB/s. The multi-master multi-slave AHB bus matrix within the system operates impeccably, ensuring smooth functionality. Furthermore, the two DMA controllers exhibit independent operation, featuring flexible start-stop capabilities. Notably, they operate harmoniously without conflicts, optimizing the area utilization while adhering to a low power consumption design methodology. The results unequivocally affirm the feasibility of designing a secure SoC integrated with two DMA controllers. This hardware-based approach effectively ensures data security, showcasing promising prospects for real-world applications.
Dog talk
Authors: Mitchell Robert W. 
Published: February 2024

Abstract
Canid and human barks and growls were examined in videotapes of 24 humans (Homo sapiens) and 24
dogs (Canis familiaris) playing with familiar and unfamiliar cross-species play partners. Barks and growls were
exhibited by 9 humans and 9 dogs. Dogs barked and (less often) growled most frequently when being frustrated by humans and/or
engaged in competitive games, and less often when being chased or inviting chase, and being instigated or captured. Dogs never
growled when playing with an unfamiliar human, and humans did so rarely when playing with an unfamiliar dog. Humans growled and
(less often) barked most frequently when chasing and capturing the dog, less often when engaging in competitive games, being
frustrated by the dog, and/or instigating the dog, and rarely when showing or throwing an object. Dog barks were most often
requests for the human to make an object available to the dog. Dog growls were often pretend threats when competing for an object
or being frustrated by the human’s actions. Human barks and growls were typically pretend threats, and were sometimes used to
emphasize simultaneous behaviors. Human barks and growls allow humans to connect with their canid partner.
Water, lava, and wind
Authors: Peres S. Camille , Mehta Ranjana K. , Murphy Robin R. 
Published: February 2024

Abstract
Small unmanned aerial systems (sUAS) are used more regularly and widely in disaster response. Like other personnel
involved in disaster response, the sUAS pilots work for long periods, experience extreme stress and fatigue. They often arrive at
the disaster fatigued (due to long drives to get there). However, unlike other personnel in this domain, there is little research
on the effects of fatigue on sUAS pilots. Our experiences with a series of three real-world deployments highlight the challenges
of conducting human factors research during disaster response and recovery. We specifically present lessons learned from having
participant researchers embedded in three disasters with the sUAS pilot teams. These lessons result in a set of feasible and
non-interruptive methods and metrics for conducting human factors research during field events. Preliminary results and
recommended next steps are presented.