bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Differential Contribution of Muscle Contraction and Migraine Symptoms to Problem Headache in the General Population
Authors: Kaganov Judith A. , Bakal Donald A. , Dunn Bruce E. 
Published: June 2005

SYNOPSISThe present study examined the prevalence of musculoskeletal, vascular and autonomic symptoms in headache sufferers in the general population. The differential contribution of these different categories of symptoms to varying degrees of problem headache was also examined. The symptoms were assessed by a 14–item questionnaire that permitted the respondents to indicate the extent to which each of the symptoms was perceived to be present across all headache attacks. In addition, a single item was included to assess the extent to which the respondents perceived their headache attacks to be a problem. Questionnaires were obtained from a systematic random sample of 1551 urban‐based households. Thirteen of the 14 symptoms showed a positive relationship between the frequency of occurrence and the extent to which headaches were perceived to be a problem. In addition a positive relationship emerged between the number of muscle contraction symptoms reported and the number of migraine symptoms reported. Additional analyses demonstrated that a reversal in symptom dominance occurred across the problem dimension in that musculoskeletal symptoms were more prevalent for headache sufferers who never or seldom perceived their headaches to be a problem while vascular symptoms were more prevalent for headache suffers who often or always perceived their headaches to be a problem. The reversal was only partial however, since the musculoskeletal symptoms of neck pain, back of head pain and feelings of tightness and pressure were found to differentiate the problem headache sufferer from the nonproblem headache sufferer. Overall, the data were viewed as providing additional support for the severity model of headache.
Behavioral Assessment Considerations in the Management of Headache
Authors: Lake Alvin E. 
Published: June 2005

SYNOPSISEffective behavioral and psychophysiological treatment requires careful assessment of three components of the headache experience: (1) observable behavior, including activity, verbal complaints, moaning and grimmacing, and medication use, (2) cognitions, including self–statements and images, and (3) physiological functioning, including symptoms associated with various levels of skeletal, autonomic, end cortical arousal. In addition, behavioral assessment includes functional analysis of the antecedents and consequents of headache episodes. Antecedents include factors external to the person, from social situations to meteorological changes, as well as internal factors including behavior patterns, thoughts, and physiological arousal. Consequents – events following the occurrence of headache – include the response of other people in the patient's environment, patterns of avoiding activities because of headache, as well as the person's own subsequent behavior, thoughts, and emotional reactions.The importance of these assessment considerations in the design of appropriate treatments is illustrated with examples from patient records. These cases suggest that effective behavioral and psychophysiological intervention may depend more on the profile revealed by this type of assessment than on the diagnosis of headache type.
The Effect of Infused Prostacyclin in Migraine and Cluster Headache
Authors: Peatfield R.C. , Gawel M.J. , Rose F. Clifford 
Published: June 2005

SYNOPSISProstacyclin appears to be the most active of the vasodilating prostaglandins with inflammatory and hyperalgesic properties. Its actions are very similar to those of prostaglandin E1, which has long been known to cause “vascular‐type” headaches. We have assessed the role of prostacyclin by infusing it into eight patients with migraine and eight with cluster headache. Most of the subjects developed a dull throbbing headache during the infusion. In most cases the nature of the induced headaches was different from those usually experienced, and not significantly different from those induced in three normal subjects.Prostacyclin, therefore, does not appear to act as sole mediator of vascular headaches, though may still do so synergistically with one of a variety of amines and peptides.
Vertigo, Motion Sickness and Migraine
Authors: Kuritzky Arieh , Ziegler Dewey K. , Hassanein Ruth 
Published: June 2005

SYNOPSISThe frequency of vestibular symptoms in 104 headache patients during the headache‐free phase was studied. The group was comprised of 84 patients with migraine (24 classical and 60 common) 12 with tension and 8 with cluster headache. Fifty‐four headache‐free subjects served as controls. All the participants filled out a vestibular symptom questionnaire.Patients with classical migraine reported significantly more vestibular symptoms than the controls. Specifically they had more dizzy spells (r = 0.002) and vertigo episodes (r = 0.01) not associated with the headache. They also had more frequent motion sickness spells. Of the classical migraine patients reporting motion sickness 87% experienced it at least once in 6 weeks compared to only 11% of the controls. Classical migraine patients also probably have an especially “sensitive” vestibular system, as evidenced by increased tendency to visual vertigo (r = 0.005) and significantly increased dizziness when they themselves were spinning.The common migraine patients showed a tendency to vestibular impairment that was not statistically significant. Recent findings of vestibular function abnormalities in this group may suggest an evolving dysfunction that is not yet symptomatic. Patients with tension and cluster headache did not differ from the controls in all the vestibular symptoms studied.In summary, our findings indicate clearly a vestibular impairment in classical migraine. The relation to “benign recurrent vertigo,” problems in the relationship of the occurrence of motion sickness to migraine and the possible mechanism causing the vestibular dysfunction are discussed.
Tyramine Sensitivity in Dietary Migraine: A Critical Review
Authors: Kohlenberg Robert J 
Published: June 2005

SYNOPSISThe hypothesis that oral tyramine causes migraine headache in certain patients was proposed by Hanington in 1967. In all, there are 11 published reports that experimentally test the hypothesis. Six of these studies provide support for the hypothesis whereas the results of four studies are clearly not supportive. All of the supporting evidence was generated in one laboratory (Hanington). In an attempt to evaluate this conflicting evidence, a comparison was made of outcome measures, subject selection procedures, and various methodological differences. There were some anomalous findings, most notably that there were marked differences in "placebo" headaches elicited by lactose capsules from study to study. Further, methodological differences among the studies preclude direct comparisons of the results. Taking these differences into account, the tyramine hypothesis appears to have some validity. The implications of these findings were discussed.
Variation in Meaning of Pain Descriptors for Different Headache Types as Revealed by Psychophysical Scaling
Authors: Blanchard Edward B. , Andrasik Frank , Arena John G. , Teders Steven J. 
Published: June 2005

SYNOPSISTursky's (1976) set of pain descriptors for the intensity and reactivity dimensions were psychophysically scaled by patients with either tension, migraine, combined migraine and tension or cluster headaches and by a group of non‐headache sufferers. The reactivity descriptors consistently discriminated headache from non‐headache subjects and tended to be aligned consistent with the severity of the pain experienced in the various kinds of headaches.
Clues in the Tempos of Cluster Headache
Authors: Kunkle E. Charles 
Published: June 2005

SYNOPSISThree striking features of the usual time patterns of cluster headache, each involving a trade‐off, offer provocative clues to headache mechanisms: (1) The high intensity is consistent with involvement of the internal carotid within its canal in an unproven but plausible process of dilatation with edema and possible sterile inflammation; the brevity of the attack may result from factors instrinsic to this arterial segment or from unusually effective pain‐suppressing feedback. (2) Rarely, in the patient with cluster headache a separate kind of pain develops, even more intense but tic‐like, possible arising from compromise of the trigeminal ganglion by the subjacent “carotid process”. (3) The major enigmatic tempo, clustering of attacks of headache separated by prolonged remissions, may denote fluctuations in autonomic vasomotor function, secondary in some individuals to changing life stress and in others to endogenous biologic rhythms. A search is warranted for biochemical evidence for cycles in activating or suppressor mechanisms, through serial assays, as of serum, in patients accessible to long‐term study.
Brainstem Influences on the Cephalic Circulation: Experimental Data From Cat and Monkey of Relevance to the Mechanism of Migraine
Authors: Lance J.W. , Lambert G.A. , Goadsby P.J. , Duckworth J.W. 
Published: June 2005

SYNOPSISStimulation of the locus ceruleus produces vasoconstriction in the intracerebral circulation and vasodilatation in the extracerebral circulation. The latter is mediated by the seventh cranial nerve, involving a non‐cholinergic transmitter. These vascular changes are reminiscent of those occurring in migraine. Stimulation of the trigeminal ganglion or of the trigeminal divisions produces a reflex dilatation in the external carotid territory also mediated by non‐cholinergic fibers in the seventh nerve.It is postulated that, in migraine, activation of the locus ceruleus would produce vasoconstriction in the cerebral circulation and dilatation extracerebrally. Such an effect would account for both the neurological symptoms of migraine and the observed changes in blood flow and vascular reactivity. Dilatation in the external carotid territory could lead to further reflex changes by activation of the central pathways described. Changes in locus ceruleus activity could be responsible for the pain of the headache phase of migraine, by disrupting a descending pain control system.
Behavioral Assessment and Treatment of Child Migraine: Implications for Clinical Research and Practice
Authors: Hoelscher Timothy J. , Lichstein Kenneth L. 
Published: June 2005

SYNOPSISBehavioral assessment and treatment strategies for adult migraine have gained wide acceptance during the past decade. However, very little research exists on the use of behavioral methods for child migraine. The present paper reviews clinical research and practice in the behavioral assessment and treatment of child migraine. Based on the available medical literature, it appears thatchild migraine closely parallels adult migraine, excepting for some neurological signs, a higher proportion of affected males, and the greater prominence of gastrointestinal upset characterizing the former. Assessment methods that have proven useful with adult migraineurs, including interview data and headache diaries, have yet to be validated with a child population. Several behavioral and social validation measures are proposed as additional assessment strategies for child migraine. Although recent studies evaluating the use of relaxation, biofeedback, and other behavioral approaches for child migraine have been encouraging, methodological shortcomings in these studies make the drawing of firm conclusions premature. It is concluded that child migraine presents a very promising research domain in light of recent successes in therapeutic trials with children and the background of successful behavioral interventions established with adults.
Is the Muscular Model of Headache Still Viable? A Review of Conflicting Data
Authors: Pikoff Howard 
Published: June 2005

SYNOPSISRecent behavioral studies have called into question the accepted model of muscle contractionheadache. This review examines origins of the model, supportive and disconfirming findings,methodological issues, and an alternative view of muscle contraction as precipitant, consequence, oraltogether absent in headache. It is concluded that overuse has weakened but not completelydiscredited the muscular model. Although some headaches are doubtless caused by muscularhyper‐activity, true muscle contraction headache is probably far less common than traditionallyassumed.
Predisposing, Precipitating and Relieving Factors in Different Categories of Headache
Authors: Drummond P.D. 
Published: June 2005

SYNOPSISSix hundred headache patients were questioned systematically about factors which precipitated, aggravated or relieved headache, their personal well‐being, symptoms of muscular contraction, and other features thought to be associated with headache (migraine in the immediate family, ice cream headache, icepick‐like pains, symptoms of orthostatic hypotension, travel sickness, and allergies). These items were analysed in relation to the clinical diagnosis (classical migraine, common migraine, tension‐vascular, tension or cluster headache), to two sets of migrainous features (symptoms of common migraine and neurological disturbances during headache), as well as the time course of headache (episodic, constant dull with more severe episodes, or constant). Differences between cluster and noncluster headache in age and sex distribution, precipitating and relieving factors, and family history of migraine supported the view that cluster headache is a distinct entity. The results of other analyses emphasized the continuum between migraine, tension‐vascular and tension headache. Indications of neurovascular involvement both during and between headache episodes were most apparent toward the migraine end of the headache spectrum, whereas psychological factors and symptoms of muscular contraction were associated more frequently with constant than with episodically‐recurring headache.
Migraine and the Noradrenergic Control of Vasomotricity: A Study With Alpha‐2 Stimulant and Alpha‐2 Blocker Drugs
Authors: Martucci N. , Manna V. , Porto C. , Agnoli A. 
Published: June 2005

SYNOPSISInvolvement of the sympathetic nervous system in the pathogenesis of migraine attack has long been hypothesized, on the basis of anatomical, clinical and biochemical data.A double‐blind placebo‐controlled randomized study was carried out on 2 groups of 20 patients each: the first was affected by common migraine, the second by tension headache. Clonidine and mianserine effects were evaluated by testing the threshold of histamine‐induced migraine, the intensity of induced pain and the migraine attacks' characteristics, after 90 days' preventive treatment. Hamilton Rating Scale for Depression was administered to evaluate anxiety and depression during the treatment. A long‐term preventive effect on migraine incidence was registered using both drugs.
Concubine Syndrome: An Example of Interactionism in the Clinical Assessment of Headache
Authors: Diamond Seymour , Maliszewski Michael 
Published: June 2005

SYNOPSISPsychological and psychiatric factors contributing to headache etiology and prevalence have been reported over the past four decades. While intrapsychic and environmental explanations have been offered, no conceptual models have been suggested which accommodate both perspectives. Proposing to remedy this deficit with the presentation of a new model, we outline a case study of what is termed the “concubine syndrome,” that is a diagnostic classification which serves to illustrate the interaction of personality traits and external stressors that contribute to a particular type of headache problem. Using an interactional model of conceptualizing and treating this disorder, a discernible improvement was noted in reduction of headache pain. Aside from presenting criteria for differential diagnosis, we recommend further research and clinical evaluations which consider using this approach to assessing and treatment of headache disorders.
Dietary Factors in Migraine Precipitation: The Physicians' View
Authors: Blau J.N. , Diamond Seymour 
Published: June 2005

SYNOPSISFive hundred and fifty questionnaires were sent to members of the American Association for the Study of Headache as well as to British physicians with a known interest in migraine. Of the 327 that replied, only 21% favored the term “dietary migraine.” To determine the presence of food sensitivity in their patients 71% relied on information from the patient's history alone. However, 21% employed special tests in addition to the history.Estimates of the percentage of patients in whom dietary factors were operative ranged from 0–80%. Seventy‐four percent were in the 0–20% range (some indicating an incidence nearer 1–5% or less). Sixteen percent estimated the range of their patients in whom diet provoked migraine was between 20–40%, three percent estimated 40–60%, and two percent 60–80%.The foods most commonly cited as triggering agents are presented in descending rate of frequency: chocolate, alcohol, cheese, monosodium glutamate, nuts, citrus fruit, meat, coffee, nitrates, fish, dairy products, onions, hot dogs, pizza, wheat products, bananas, tomatoes, apples, and various vegetables.Individual comments invited on the questionnaire are described.The consensus is that foods or alcohol can provoke occasional attacks in some patients. They conclude that the appropriate term is “dietary precipitated migraine.”
The Influence of Plasma Free Fatty Acids and Cholesterol on the Aggregation of Blood Platelets in Migraine Patients
Authors: Kozubski Wojciech , Stanczyk Lidia 
Published: June 2005

SYNOPSISThe Platelet Aggregate Ratio (PAR) was determined in 34 women with common migraine during headache‐free intervals. Fourteen of them were studied also during migraine attacks.The levels of FFA and total cholesterol in the blood were determined simultaneously to assess their influence on aggregation of blood platelets.Plasma FFA levels rose significantly during headache (r<0.001). The levels of total blood cholesterol did not show a homogenous distribution. In 20 patients blood cholesterol was elevated; in the remaining 14 patients levels were within the standard range.The migraineurs with high cholesterol showed a significantly lower PAR during headache‐free intervals than did the control subjects (r<0.001). There was no significant difference between PAR in migraineurs with normal cholesterol and the controls. A significant fall of PAR during migraine attacks was observed only in migraineurs with high cholesterol (r<0.01). There was a significant correlation between the falling of PAR and the level of blood cholesterol (r<0.05). The same correlation was found between the falling of PAR and the rising of FFA during migraine attacks (r<0.05).We suggest that FFA can raise the number of circulating platelet aggregates during migraine episodes. Total blood cholesterol is one of the factors which define migraine populations with respect to platelet aggregation.
Unnecessary Dental Treatment of Headache Patients for Temporomandibular Joint Disorders
Authors: Reik Louis 
Published: June 2005

SYNOPSISThe charts of 100 consecutive headache clinic patients were reviewed retrospectively to determine the frequency of prior dental treatment for TMJ disorders. Twenty had been treated, but only 4 satisfied our diagnostic criteria for the TMJ pain‐dysfunction syndrome. The other 16 satisfied conventional criteria for other headache diagnoses, and none of them had improved with dental treatment. Increased patient awareness of the TMJ syndrome, inappropriate referral by physicians and incorrect diagnosis by dentists all probably led to the unnecessary dental treatment.
A Case of Ophthalmoplegic Migraine With Ipsilateral CT‐Documented Hypodense Lesions
Authors: Moretti Giacomo , Scoditti Umberto , Rustichelli Paolo , Manzoni Gian Camillo , Parma Mario 
Published: June 2005

SYNOPSISThe case of a young woman whose clinical picture was suggestive of ophthalmoplegic migraine is reported. In light of an unprecedented finding of two CT documented transient hypodense lesions in the hemisphere ipsilateral to the oculomotor paralysis, the prevalent theories about the pathogenesis of ophthalmoplegia in this type of migraine are reviewed.
Unusual Transient High and Low Density CT Lesion in Migraine: A Case Report
Authors: Jain S. , Ahuja G.K. 
Published: June 2005

SYNOPSISIn a patient suffering from classical migraine, an unenhanced CT scan done a few hours after a recentepisode of headache revealed a low‐density area in the right occipital region. On contrast enhancement, apeculiar high‐density lesion surrounded by a large low‐density area was seen in the same region. This CTscan abnormality totally disappeared spontaneously within two months. Such lesions have been seen inpatients suffering from epilepsy. The possible pathogenetic mechanism is a localized disruption in theblood‐brain barrier during the phase of vasoconstriction. Such a CT scan abnormality in patients sufferingfrom migraine has not been reported earlier.
The Validity of the Vascular "Cold Patch" in the Diagnosis of Chronic Headache
Authors: Swerdlow Bernard , Dieter John Nathan 
Published: June 2005

SYNOPSIS“Cold patches” in the external carotid territory previously have been described to have been associatedwith vascular‐related headaches. This study utilizes electronic thermography to examine the relationship.A sample of 275 patients diagnosed as having: vascular, scalp muscle contraction, cluster, post‐traumaticor psychogenic headaches, as well as 45 headache‐free individuals, served as subjects. Each subject wasadministered electronic thermography to determine if “cold patches” were present in the external carotidterritory. A “cold patch” was defined as a region more than 0.5°C cooler than the surrounding area.Chi Square analysis determined that vascular headache patients displayed a significantly greater number(p<.001) of “cold patches” than did normal individuals, or patients having scalp muscle contraction,psychogenic, or post‐traumatic type I headaches. Mixed headaches involving a vascular component alsodisplayed a significantly greater number (p< .001) of “cold patches,” as did cluster disorders (p<.001), andpost‐traumatic type III headaches (p<.001).This evidence supports a valid relationship between "cold patches" and vascular‐related headaches. It issuggested that the vascular “cold patch” be included as part of the criteria in assessing headaches.
Headaches and Heart Disease: The Lack of a Positive Association
Authors: Featherstone Harvey J. 
Published: June 2005

SYNOPSISIn order to investigate the relationship between headaches and cardiovascular disease, 200 individuals with recurrentidiopathic headaches were compared with age‐ and sex‐matched controls for the prevalence of cardiovasculardiagnoses and electrocardiographic (ECG) abnormalities. Only hypertension was diagnosed more frequently in theheadache group; ischemic heart disease and valvular lesions were diagnosed equally in some cases and controls, aswere rhythm disturbances. Matched ECG's were available in 161 pairs. Ischemic ECG changes were more frequent inthe controls than the headache cases. There were no other differences in ECG findings. This study fails to show apredilection for cardiovascular diseases, other than hypertension, in individuals with headaches. Ischemic heart diseasemay, by ECG analysis, be less common in headache cases than nonheadache controls.