bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic ultrasound‐guided gallbladder drainage with long‐term lumen‐apposing metal stent indwell: 1‐year results from a prospective nationwide observational study
Authors: Bazaga Sergio , García‐Alonso Francisco Javier , Aparicio Tormo Jose Ramon , Martinez Moreno Belen , Sanchiz Vicente , Gornals Joan B , Loras Carme , Terán Álvaro , Vazquez‐Sequeiros Enrique , Pedraza Sanz Rafael , Súbtil José Carlos , Pérez‐Millan Antonio , Uceda Porta Francisco , Vila Juan J , de la Serna‐Higuera Carlos , Couto‐Worner Ignacio , Guarner‐Argente Carlos , Perez‐Miranda Manuel ,   the RNPAL (Registro nacional de prótesis de aposición luminal, national lumen‐apposing metal stent registry) study group
Published: November 2023

AbstractBackground and AimThis study aimed to determine safety and risk factors for adverse events (AEs) of endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) with long‐term indwell of lumen‐apposing metal stents (LAMS).MethodsThis study is a multicenter prospective observational study on consecutive high surgical‐risk patients requiring gallbladder drainage who underwent EUS‐GBD with LAMS over 12 months. Centralized telephone follow‐up interviews were conducted every 3 months for 1 year. Patients were censored at LAMS removal, cholecystectomy, or death. AE‐free survival was determined using log–rank tests. Cumulative risks were estimated using life‐table analysis.ResultsEighty‐two patients were included (53.7% male, median [interquartile range] age of 84.6 [76.5–89.8] years, and 85.4% with acute cholecystitis). Technical success was achieved in 79 (96.3%), and clinical success in 73 (89%). No patient was lost to follow‐up; 45 patients (54.9%) completed 1‐year follow‐up with in situ LAMS. Median (interquartile range) LAMS indwell time was 364 (47–367) days. Overall, 12 (14.6%) patients presented 14 AEs, including 5 (6.1%) recurrent biliary events (3 acute cholangitis, 1 mild acute pancreatitis, and 1 acute cholecystitis). Patients with pancreatobiliary malignancy had an increased risk of recurrent biliary events (33% vs 1.5%, P = 0.001). The overall 1‐year cumulative risk of recurrent biliary events was 9.7% (4.1–21.8%). The 1‐year risk of AEs and of severe AEs was 18.8% (11–31.2%) and 7.9% (3.3–18.2%), respectively. Pancreatobiliary malignancy was the single risk factor for recurrent biliary events; LAMS misdeployment was the strongest risk factor for AEs.ConclusionsLong‐term LAMS indwell does not increase the risk of delayed AEs following EUS‐GBD.
Intervention with Screening in Panic‐Based Runs
Authors: SHEN LIN , ZOU JUNYUAN 
Published: November 2023

ABSTRACTPolicymakers frequently use guarantees to mitigate panic‐based runs in the financial system. We analyze a binary‐action coordination game under the global games framework and propose a novel intervention program that screens investors based on their heterogeneous beliefs about the system's stability. The program only attracts investors who are at the margin of running, and their participation boosts all investors' confidence in the financial system. Compared with government guarantee programs, our proposed program is as effective at mitigating runs but features two advantages: it costs less to implement and it is robust to moral hazard.
Children's scabies survey indicates high prevalence and misdiagnosis in Auckland educational institutions
Authors: Thornley Simon , Sundborn Gerhard , Engelman Daniel , Roskvist Rachel , Pasay Cielo , Marshall Roger , Long Wei , Dugu Noela , Hopoi Natalie , Moritsuka Shunsuke , McCarthy James , Morris Arthur J 
Published: November 2023

AimHere, we present results of a survey of scabies prevalence in childcare centres and primary schools in Auckland.MethodsChildren whose parents agreed to take part in participating centres in the Auckland region were examined for scabies by general practitioners and given questionnaires of relevant symptoms. Diagnoses of clinical or suspected scabies were made according to the International Alliance for the Control of Scabies (IACS) criteria. The survey was a stratified random sample of schools and early childcare centres. A quantitative polymerase chain reaction (PCR) test was also used to complement the IACS criteria.ResultsA total of 181 children were examined, with 145 children with history information, 16 of whom (11.0%) met the criteria for ‘clinical’ or ‘suspected’ scabies. Weighted analysis, accounting for the survey design, indicated that the prevalence of scabies in early childcare centres was 13.2% (95% CI: 4.3 to 22.1), with no school‐aged children fulfilling these criteria. A higher proportion had clinical signs of scabies with 23 (12.7%) having typical scabies lesions and a further 43 (23.8%) had atypical lesions. A total of 64 PCR tests were taken and 15 (23%) were positive. None of these cases were receiving treatment for scabies. Five were undergoing topical skin treatment: three with topical steroid and two with calamine lotion.ConclusionsThe prevalence of children with scabies is high in early childcare centres in Auckland. Misdiagnosis is suggested by several PCR positive cases being treated by topical agents used to treat other skin conditions.
Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition
Authors: Havlickova Lenka , He Zhesi , Berger Madeleine , Wang Lihong , Sandmann Greta , Chew Yen Peng , Yoshikawa Guilherme V. , Lu Guangyuan , Hu Qiong , Banga Surinder S. , Beaudoin Frederic , Bancroft Ian 
Published: November 2023

SummaryRapeseed is a crop of global importance but there is a need to broaden the genetic diversity available to address breeding objectives. Radiation mutagenesis, supported by genomics, has the potential to supersede genome editing for both gene knockout and copy number increase, but detailed knowledge of the molecular outcomes of radiation treatment is lacking. To address this, we produced a genome re‐sequenced panel of 1133 M2 generation rapeseed plants and analysed large‐scale deletions, single nucleotide variants and small insertion–deletion variants affecting gene open reading frames. We show that high radiation doses (2000 Gy) are tolerated, gamma radiation and fast neutron radiation have similar impacts and that segments deleted from the genomes of some plants are inherited as additional copies by their siblings, enabling gene dosage decrease. Of relevance for species with larger genomes, we showed that these large‐scale impacts can also be detected using transcriptome re‐sequencing. To test the utility of the approach for predictive alteration of oil fatty acid composition, we produced lines with both decreased and increased copy numbers of Bna.FAE1 and confirmed the anticipated impacts on erucic acid content. We detected and tested a 21‐base deletion expected to abolish function of Bna.FAD2.A5, for which we confirmed the predicted reduction in seed oil polyunsaturated fatty acid content. Our improved understanding of the molecular effects of radiation mutagenesis will underpin genomics‐led approaches to more efficient introduction of novel genetic variation into the breeding of this crop and provides an exemplar for the predictive improvement of other crops.
Experimental evidence on the determinants of citizens' expectations toward public services
Authors: Bellé Nicola , Belardinelli Paolo , Cucciniello Maria , Nasi Greta 
Published: November 2023

AbstractWe conducted three randomized experiments to investigate whether and to what extent citizens' expectations toward waiting times for public service delivery are influenced by reference points, either in the form of social or numerical references. Consistent with our theoretical expectations, our results provide convergent evidence of reference dependence. Specifically, informing citizens that waiting times are longer (shorter) relative to a social reference causes an increase (decrease) in expected waiting times. Additionally, due to an anchoring bias, priming citizens with a higher numerical value for waiting times extends their expected waiting times. Furthermore, in line with the expectancy‐disconfirmation model, citizens' satisfaction with the service is causally impacted by the extent to which actual performance exceeds their expectations.
Donor pregnancies and transfusion recipient mortality: A role for red blood cell storage?
Authors: Valk Sarah J. , Caram‐Deelder Camila , Evers Dorothea , de Vooght Karen M. K. , van de Kerkhof Daan , Wondergem Marielle J. , Péquériaux Nathalie C. V. , Hudig Francisca , Zwaginga Jaap Jan , de Korte Dirk , van de Watering Leo M. G. , Middelburg Rutger A. , van der Bom Johanna G. 
Published: November 2023

AbstractBackground and ObjectivesDonor characteristics have been implicated in transfusion‐related adverse events. Uncertainty remains about whether sex, and specifically pregnancy history of the blood donor, could affect patient outcomes. Whether storage duration of the blood product could be important for patient outcomes has also been investigated, and a small detrimental effect of fresh products remains a possibility. Here, we hypothesize that fresh red blood cell products donated by ever‐pregnant donors are associated with mortality in male patients.Materials and MethodsWe used data from a cohort study of adult patients receiving a first transfusion between 2005 and 2015 in the Netherlands. The risk of death after receiving a transfusion from one of five exposure categories (female never‐pregnant stored ≤10 days, female never‐pregnant stored >10 days, female ever‐pregnant stored ≤10 days, female ever‐pregnant stored >10 days and male stored for ≤10 days), compared to receiving a unit donated by a male donor, which was stored for >10 days (reference), was calculated using a Cox proportional hazards model.ResultsThe study included 42,456 patients who contributed 88,538 person‐years in total, of whom 13,948 died during the follow‐up of the study (33%). Fresh units (stored for ≤10 days) from ever‐pregnant donors were associated with mortality in male patients, but the association was not statistically significant (hazard ratio 1.39, 95% confidence interval 0.97–1.99). Sensitivity analyses did not corroborate this finding.ConclusionThese findings do not consistently support the notion that the observed association between ever‐pregnant donor units and mortality is mediated by blood product storage.
Identifying Predictors of Burnout and Health of Certified Mental Performance Consultants
Authors: Magdaleno Anthony , Meyer Barbara B. 
Published: November 2023

Researchers have established factors that impair (e.g., stress) or facilitate (e.g., occupational recovery) health among professionals operating in sport and performance (e.g., coaches). However, there is a paucity of research examining factors that impair or facilitate the health of sport psychology professionals. Given that sport psychology professionals have an obligation to manage their health to maintain effective service provision, research is needed to fill this gap. The purpose of this study was to identify predictors of burnout and health among certified mental performance consultants. Participants completed measures of perceived stress, burnout, occupational recovery, and health-related quality of life. Regression results, including a moderator analysis, indicated that perceived stress and occupational recovery predicted burnout, while occupational recovery moderated the relationship between perceived stress and burnout. Perceived stress and burnout further predicted health-related quality of life. Recommendations include certified mental performance consultants spending nonwork time in low-effort and/or physical activities, as well as exerting autonomy over nonwork time.
Draft-genome sequences of
Leptospira santarosai
strains isolated from urogenital tract of cows
Authors: Di Azevedo Maria Isabel Nogueira , Kremer Frederico , Ezepha Camila , Kraychete Gabriela Bergiante , Bourhy Pascale , Lilenbaum Walter 
Published: November 2023

ABSTRACT

Leptospira santarosai
serovar Guaricura is adapted to bovines and is associated with a chronic disease that causes reproductive disorders, leading to important economic losses. Here, we present the draft genomes of three
L. santarosai
strains isolated from vaginal fluid and one from the urine of cows with reproductive disorders from Brazil.
High-resolution geophysical and geochronological analysis of a relict shoreface deposit offshore central California: Implications for slip rate along the Hosgri fault
Authors: Kluesner Jared W. , Johnson Samuel Y. , Nishenko Stuart P. , Medri Elisa , Simms Alexander R. , Greene H. Gary , Gray Harrison J. , Mahan Shannon A. , Padgett Jason S. , Krolczyk Emma T. , Brothers Daniel S. , Conrad James E. 
Published: November 2023

Abstract
The Cross-Hosgri slope is a bathymetric lineament that crosses the main strand of the Hosgri fault offshore Point Estero, central California. Recently collected chirp seismic reflection profiles and sediment cores provide the basis for a reassessment of Cross-Hosgri slope origin and the lateral slip rate of the Hosgri fault based on offset of the lower slope break of the Cross-Hosgri slope. The Cross-Hosgri slope is comprised of two distinct stratigraphic units. The lower unit (unit 1) overlies the post–Last Glacial Maximum transgressive erosion surface and is interpreted as a Younger Dryas (ca. 12.85–11.65 ka) shoreface deposit based on radiocarbon and optically stimulated luminescence (OSL) ages, Bayesian age modeling, seismic facies, sediment texture, sediment infauna, and heavy mineral component. The shoreface was abandoned and partly eroded during rapid sea-level rise from ca. 11.5 to 7 ka. Unit 2 consists of fine sand and silt deposited in a midshelf environment when the rate of sea-level rise slowed between ca. 7 ka and the present. Although unit 2 provides a thin, relatively uniform cover over the lower slope break of the older shoreface, this feature still represents a valuable piercing point, providing a Hosgri fault slip rate of 2.6 ± 0.8 mm/yr. Full-waveform processing of chirp data resulted in significantly higher resolution in coarser-grained strata, which are typically difficult to interpret with more traditional envelope processing. Our novel combination of offshore radiocarbon and OSL dating is the first application to offshore paleoseismic studies, and our results indicate the utility of this approach for future marine neotectonic investigations.
Low-dose nivolumab and cabozantinib in recurrent intestinal-type papillary adenocarcinoma of the sinonasal region
Authors: Thomas Zachariah , Jambunathan Prashant , Jibi Anjali , John Ajoy Oommen , Singh Ashish 
Published: November 2023

Intestinal-type sinonasal adenocarcinoma is a rare epithelial malignancy primarily treated with surgery and chemoradiation. The combination of low-dose immunotherapy and a tyrosine kinase inhibitor in recurrent disease has not been previously studied.A man in his 20s with papillary adenocarcinoma of the sinonasal region, following surgical resection, was treated with six cycles of concurrent chemoradiotherapy, followed by four cycles of docetaxel, cisplatin and capecitabine. While on treatment, he was found to have extensive residual disease and he was started on low-dose nivolumab and cabozantinib. Repeat imaging after ten months of treatment revealed a significant reduction in lesions.Non-squamous head and neck cancers are often excluded from major trials, and the effect of immunotherapy in these histologies is poorly understood. The response seen with low-dose immunotherapy underscores the need for further research in this setting.
Perception of and legal compliance with the law prohibiting cigarette sales to minors in Thailand following the raising of the minimum selling age to 20 years: a cross-sectional survey
Authors: Phetphum Chakkraphan , Chomson Supatana , Wangwonsin Artittaya , Prajongjeep Atchara , Keeratisiroj Orawan 
Published: November 2023

ObjectivesThe minimum age for cigarette sales in Thailand was increased from 18 to 20 years, as stipulated in the Tobacco Products Control Act B.E. 2017. This study investigated tobacco retailers’ perceptions, cigarette sales behaviour and other factors relevant to selling cigarettes to people younger than 20 years in areas surrounding schools in Thailand.DesignCross-sectional survey.SettingTobacco shops within a radius of 500 m of secondary schools across four regions of Thailand. Data collection took place between May and August 2019.Participants1440 tobacco retailers (grocery or convenience stores) were sampled via a stratified, two-stage cluster sampling method. 1021 retailers completed the self-administered questionnaire.Outcome measuresTobacco sales to people younger than 20 years.ResultsThe prevalence of the retailers’ cigarette sales to youth younger than 20 years was 38.20% (95% CI 35.2% to 41.3%). Multivariable logistic regression analysis revealed associations with sale of single cigarettes (adjusted OR (AOR) 23.14, 95% CI 15.13 to 35.39), self-service sale of cigarettes (4.21, 2.59 to 6.86) and display of cigarettes at the point of sale (2.39, 1.47 to 3.89). Cigarette sales to underage youth were higher among retailers located in the northeast region (AOR 2.09, 95% CI 1.20 to 3.64) and among those who did not perceive the prosecution of violators in the past year (1.85, 1.16 to 2.96).ConclusionA large percentage of cigarette retailers violated the laws related to underage cigarette sales. Measures to minimise retailers’ legally non-compliant sales behaviours should be implemented along with improved legal enforcement.
Predictive model for estimating the risk of high-altitude pulmonary edema: a single-centre retrospective outcome-reporting study
Authors: Suona Yangzong , Gesang Luobu , Danzeng Zhuoga , Ci Bai , Zhaxi Quzong , Huang Ju , Zhang Rui 
Published: November 2023

ObjectiveTo develop the first prediction model based on the common clinical symptoms of high-altitude pulmonary edema (HAPE), enabling early identification and an easy-to-execute self-risk prediction tool.MethodsA total of 614 patients who consulted People’s Hospital of Tibet Autonomous Region between January 2014 and April 2022 were enrolled. Out of those, 508 patients (416 males and 92 females) were diagnosed with HAPE and 106 were patients without HAPE (33 females and 72 males). They were randomly distributed into training (n=431) and validation (n=182) groups. Univariate and multivariate analysis were used to screen predictors of HAPE selected from the 36 predictors; nomograms were established based on the results of multivariate analysis. The receiver operating characteristic curve (ROC) was developed to obtain the area under the ROC curve (AUC) of the predictive model, and its predictive power was further evaluated by calibrating the curve, while the Decision Curve Analysis (DCA) was developed to evaluate the clinical applicability of the model, which was visualised by nomogram.ResultsAll six predictors were significantly associated with the incidence of HAPE, and two models were classified according to whether the value of SpO2(percentage of oxygen in the blood) was available in the target population. Both could accurately predict the risk of HAPE. In the validation cohort, the AUC of model 1 was 0.934 with 95% CI (0.848 to 1.000), and model 2 had an AUC of 0.889, 95% CI (0.779 to 0.999). Calibration plots showed that the predicted and actual HAPE probabilities fitted well with internal validation, and the clinical decision curve shows intervention in the risk range of 0.01–0.98, resulting in a net benefit of nearly 99%.ConclusionThe recommended prediction model (nomogram) could estimate the risk of HAPE with good precision, high discrimination and possible clinical applications for patients with HAPE. More importantly, it is an easy-to-execute scoring tool for individuals without medical professionals’ support.
Impact of quality improvement interventions on facility readiness, quality and uptake of maternal and child health services in developing regions of Ethiopia: a secondary analysis of programme data
Authors: Dadi Tegene Legese , Abebo Teshome Abuka , Yeshitla Aklilu , Abera Yared , Tadesse Derebe , Tsegaye Sentayehu , Gerbaba Mulusew Jebena , Worke Mulugeta Dile , Tadesse Daniel , Medhin Girmay 
Published: November 2023

BackgroundQuality improvement intervention (QI) was implemented from 2018 to 2021 in health facilities of developing regional states of Ethiopia. The main objective of this study was to examine the impact of QI interventions on facility readiness, service availability, quality and usage of health services in these regions.MethodsWe used district health information system data of 56 health facilities (HFs). We also used baseline and endline QI monitoring data from 28 HFs. Data were summarised using descriptive statistics and various tests. Regression analysis was employed to examine the impact of QI interventions on various outcomes.ResultThe QI intervention improved readiness of HFs, service availability and quality of maternal and child health service delivery. The mean availability of basic amenities increased from 1.89 to 2.89; HF cleanliness score increased from 4.43 to 5.96; family planning method availability increased from 4 to 5.75; score for emergency drugs at labour ward increased from 5.32 to 7.00; and the mean score for basic emergency obstetric and newborn care service availability increased from 5.68 to 6.75; intrauterine contraceptive devices removal service increased from 39.3% to 82.1%; and partograph use increased from 53.6% to 92.9%. HFs that use partograph for labour management increased by 39.3%. The QI intervention increased the quality of antenatal care by 29.3%, correct partograph use by 51.7% and correct active third-stage labour management, a 19.6% improvement from the baseline. The interventions also increased the service uptake of maternal health services, but not significantly associated with improvement in contraceptive service uptake.ConclusionThe integrated QI interventions in HFs could have an impact on facility readiness for service delivery, service accessibility and quality of service delivery. The effectiveness of the QI intervention should be evaluated using robust methods, and efforts to enhance contraceptive services through a QI approach requires further study.