bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes
Authors: Ghaderi Mehran , Wallin Keng‐Ling , Wiklund Fredrik , Zake Liene Nikitina , Hallmans Göran , Lenner Per , Dillner Joakim , Sanjeevi Carani B. 
Published: October 2002

AbstractThe genes encoding human leukocyte antigens (HLA) have shown to be associated with cervical neoplasia. To obtain reliable data on HLA associations with cervical tumors, the study should be performed within a strictly defined cohort. To investigate the population attributable risk of cervical cancer associated with the HLA class II haplotypes DR15 and DQ6 (DQA1*0102 and DQB1*0602), we performed a nested case‐control study of 85 women who developed invasive cervical cancer and 120 healthy women from a population‐based cohort of Swedish women. The relative risks of cervical cancer among DR15 and DQ6‐positive women were 3.73 [confidence interval (CI): 1.8–7.4] and 4.33 (CI: 2.1–8.5), corresponding to population attributable proportions of 27.9% and 30.8%, respectively. A susceptibility locus in the HLA class II region is involved in a substantial fraction of the etiology of cervical cancer. © 2002 Wiley‐Liss, Inc.
The importance of maternal state of mind regarding attachment and infant age at placement to foster mothers' representations of their foster infants
Authors: Bates Brady C. , Dozier Mary 
Published: October 2002

AbstractPrevious research has found that foster mother state of mind with respect to attachment and infant age at placement into foster care influence the developing foster mother–foster child relationship (Dozier, Albus, Stovall, & Bates, 2000; Stovall & Dozier, 2000). This study extends prior research by assessing factors related to foster mothers' representations of their foster infants. Participants were 48 foster mother–foster infant dyads in two mid‐Atlantic cities. We expected that foster mothers' states of mind and infant age at placement would be associated with foster mothers' acceptance of infants, commitment to infants, and belief in their influence on infants' development. Consistent with hypotheses, foster mothers' states of mind interacted with infant age at placement in predicting foster mothers' acceptance of their babies, and the extent to which foster mothers believed they could influence their infants' development. Specifically, autonomous foster mothers of babies placed before 12 months of age were more accepting and more likely to believe they could influence their infants' development compared to autonomous foster mothers of babies placed after 12 months of age, a pattern not seen for nonautonomous foster mothers. These results converge with other findings suggesting that timing of placement in foster care, and foster mothers' states of mind, are important to the developing foster mother–child relationship. ©2002 Michigan Association for Infant Mental Health.
Six‐month follow‐up of two mother–infant psychotherapies: Convergence of therapeutic outcomes
Authors: Cohen Nancy J. , Lojkasek Mirek , Muir Elisabeth , Muir Roy , Parker Carol Jane 
Published: October 2002

AbstractFifty‐eight mothers and infants participating in two infant–mother psychotherapeutic interventions in a comparative infant–mother clinical intervention study were followed six months after treatment ended. One treatment was an infant‐led psychotherapy, Watch, Wait, and Wonder (WWW). The other was a more traditional mother–infant psychodynamic psychotherapy (PPT). Infants ranged in age from 10 to 30 months at the outset of treatment, which took place in weekly sessions over approximately five months. Results indicated that positive effects observed from the beginning to the end of treatment in both treatment groups in infant symptoms, parenting stress, and mother–infant interaction were maintained or improved further at six‐month follow‐up. Additionally, decreased maternal depression, gains in infant cognitive development and emotion regulation, and improved infant–mother attachment security or organization had been observed posttreatment only in the WWW group. Interestingly, between the posttreatment to follow‐up period the PPT group also showed such gains. Thus, for these variables it would be more accurate to say that the outcomes were similar for the two treatment groups but change emerged at a different pace. Nevertheless, an advantage persisted in the WWW group in relation to mothers' comfort dealing with infant behaviors and their ratings of parenting stress which improved more in this group from the end of treatment to follow‐up. The direct inclusion of the infant as an initiator in WWW was set forth as an explanation of differentially timed treatment effects. ©2002 Michigan Association for Infant Mental Health.
E‐controlling: Ten Challenges for Controlling and Management Accounting
Authors: Erben Roland Franz 
Published: October 2002

AbstractTo keep pace with a rapidly changing and increasingly complex business environment, companies need to adapt and

modify their tool sets for strategic management accounting. On an operational level, the widespread use of modern

information and communication technologies has enabled a radical redesign of business processes. Modern

information and communication technologies can help leverage the efficiency of accounting and controlling

processes. © 2002 Wiley Periodicals, Inc.
Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line
Authors: Hall J. Perry , Davis Roger J. 
Published: October 2002

AbstractMitogen‐activated protein (MAP) kinases have been implicated as important mediators of the inflammatory response. Here we report that c‐Jun NH2‐terminal kinase (JNK), extracellular signal‐regulated kinase (ERK), and p38 MAP kinase activities are reprogrammed during the IL‐6 induced macrophage‐like differentiation of the murine myeloid M1 cell line. Moreover, p38 inhibition upregulates JNK and ERK activity in M1 cells and in thioglycollate‐elicited peritoneal exudate macrophages. IL‐6‐induced M1 differentiation also induces expression of the anti‐inflammatory cytokine IL‐10, and p38 inhibition potentiates this increase in IL‐10 expression in an ERK‐dependent manner. Thus, we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and ERK activity and inhibit IL‐10 expression. These data highlight the importance of p38 in the molecular mechanisms of macrophage function. J. Cell. Biochem. 86: 1–11, 2002. © 2002 Wiley‐Liss, Inc.
Nuclear matrix proteins as biomarkers in prostate cancer
Authors: Leman Eddy S. , Getzenberg Robert H. 
Published: October 2002

AbstractThe nuclear matrix (NM) is the structural framework of the nucleus that consists of the peripheral lamins and pore complexes, an internal ribonucleic protein network, and residual nucleoli. The NM contains proteins that contribute to the preservation of nuclear shape and its organization. These protein components better known as the NM proteins have been demonstrated to be tissue specific, and are altered in many cancers, including prostate cancer. Alterations in nuclear morphology are hallmarks of cancer and are believed to be associated with changes in NM protein composition. Prostate cancer is the most frequently diagnosed cancer in American men and many investigators have identified unique NM proteins that appear to be specific for this disease. These NM protein changes are associated with the development of prostate cancer, as well as in some cases being indicative of cancer stage. Identification of these NM proteins specific for prostate cancer provides an insight to understanding the molecular changes associated with this disease. This article reviews the role of NM proteins as tumor biomarkers in prostate cancer and the potential application of these proteins as therapeutic targets in the treatment of this disease. J. Cell. Biochem. 86: 213–223, 2002. © 2002 Wiley‐Liss, Inc.
1,25(OH)2D3‐mediated phosphate uptake in isolated chick intestinal cells: Effect of 24,25(OH)2D3, signal transduction activators, and age
Authors: Zhao Bin , Nemere Ilka 
Published: October 2002

AbstractWe have previously reported an absence of a 1,25(OH)2D3‐mediated effect on 45Ca handling by intestinal epithelial cells isolated from normal chicks (Nemere and Campbell [2000] Steroids 65:451–457). In the current work, we provide evidence that in similar cell preparations, 1,25(OH)2D3 increased 32P uptake within 5 min of addition, and reached 150% of controls after 10 min (P < 0.05). Both isolated enterocytes and the perfused duodenal loop system exhibited apparent biphasic dose–response curves for 1,25(OH)2D3‐stimulated 32P uptake and transport, and inhibition of stimulation by 24,25(OH)2D3. A comparison of signal transduction activators demonstrated the following parallels in both isolated intestinal cells and perfused duodena: lack of effect of forskolin (a protein kinase (PK) A activator) on 32P handling, but simulation by BAY K8644 (a calcium channel activator) and phorbol ester (a PKC activator). Finally, we tested the effect of 1,25(OH)2D3 on phosphate uptake in epithelial cells isolated from birds of increasing ages (7, 14, and 28 wk). In contrast to the robust response of cells from young, growing chicks, 1,25(OH)2D3 had no effect on enterocytes from 14 or 28 wk birds. Western analyses with Ab 099 against the 1,25(OH)2D3 (1,25D3)‐Membrane‐Associated Rapid Response Steroid (MARRS) binding protein revealed a decrease in average density of the immunoreactive band with age. PKC activity determined in isolated epithelial cells exhibited a decrease in average basal (control) activity with age, as well as a decrease in response to 1,25(OH)2D3 activation. In enterocytes from 7–14‐ or 28‐week birds, PKC was enhanced 170, 120, and 105% of controls, respectively. The combined data validate 32P uptake in isolated enterocytes as a model system to study 1,25D3‐MARRS protein function, and indicate that for phosphate transport, the rapid actions of 1,25(OH)2D3 are physiologically more important in growing animals than immature ones. J. Cell. Biochem. 86: 497–508, 2002. © 2002 Wiley‐Liss, Inc.
FA(I):Au+andFA(II):Cu+laser activity and photographic sensitization at the low coordinated surfaces of AgBrab initiocalculations
Authors: Shalabi A. S. 
Published: October 2002

AbstractThe twofold potentials ofFA(I):Au+andFA(II)Cu+color centers at the low coordinated surfaces of AgBr thin films in providing tunable laser activity and photographic sensitization were investigated usingab initiomethods of molecular electronic structure calculations. Clusters of variable size were embedded in simulated Coulomb fields that closely approximated the Madelung fields of the host surfaces, and the nearest neighbor ions to theFAdefect site were allowed to relax to equilibrium in each case. Based on the calculated Stokes shifted optical transition bands and horizontal shifts along the configuration coordinate diagrams, bothFA(I):Au+andFA(II):Cu+color centers were found to be laser active. The laser activity faded quickly as the bromide ion coordination decreased from 5 (flat) to 4 (edge) to 3 (corner) and as the size of the impurity cation increased from Cu+to Au+. The latter relation was explainable in terms of the axial perturbation of the impurity cation. The smallest calculated Stokes‐shift at the corner surface suggested that emission had the same oscillator strength as absorption. All relaxed excited states RESs of the defect containing surfaces were deep below the lower edges of the conduction bands of the defect free ground state surfaces, indicating thatFA(I):Au+andFA(II):Cu+are suitable laser defects. The probability of orientational destruction of the two centers attributed to the assumed RES saddle point ion configurations along the 〈110〉 axis was found to be directly proportional to the size of the impurity cation, with activation energy barriers of about 0.655–3.294 eV for Cu+, and about 1.887–3.404 eV for Au+. The possibility of exciton (energy) transfer from the sites of higher coordination to those of lower coordination is demonstrated. The more laser activeFA(II):Cu+center was more easily formed than the less laser activeFA(I):Au+center. The Glasner‐Tompkins empirical relation was generalized to includeFAcenters at the low coordinated surfaces of silver bromide thin film. As far as color photographic sensitization is concerned, the lowest unoccupied molecular orbitals of the selected dye molecules in the excited states were high enough for electron injection.FAdefect formation and rotational diffusion of silver clusters reduced the energy gaps between the excited dye molecules and the lower edges of the conduction bands and allowed for hole injection. About 54–60% of the reduction of silver ions at the flat surface of AgBr was attributed to the host anions andFAdefect formation, leaving about 40–46% for the reduction of photoelectrons as well as the electrons of the developer or dye molecules. The unrelaxed rotational diffusions of the central Ag4by 90° decreased the latter percentage, but were severely hindered by activation energy barriers. © 2002 Wiley Periodicals, Inc. J Comput Chem 23: 1104–1120, 2002
Relationships among perceptions of parent involvement, time allocation, and demographic characteristics: Implication for policy formation
Authors: Ritblatt Shulamit N. , Beatty James R. , Cronan Terry A. , Ochoa Alberto M. 
Published: October 2002

AbstractVariables that facilitate or hinder parent involvement (PI) in education and schools were explored, along with the amounts of time parents spent in various activities. A total of 506 participants from San Diego and Imperial Counties completed the first part of the study (1) designed to assess parents' beliefs about involvement with their child's school and education. Of these same participants, 357 self‐selected parents also chose to complete a second part of the study (2) that assessed the amount of time parents spend in education‐related activities. Factor analysis of the 506 participant responses revealed four school perception factors related to parent attitudes: (a) communication, (b) familiarity, (c) sensitivity, and (d) support. Factor analysis of the 357 participant responses to the time factors also revealed four involvement areas: (a) general school issues, (b) specific school issues, (c) extracurricular school activities, and (d) specific help. Significant relationships were found among three of the attitudinal factors (sensitivity, familiarity, and support) and various time factors, including total involvement time, general issues, specific problems, and extracurricular issues. Further, significant differences among means were found for both the school perception factors and the time factors based on ethnic background, income, and marital status. Recommendations for increasing parent involvement and formulating public policy are discussed. © 2002 Wiley Periodicals, Inc.
Interagency teams: A vehicle for service delivery reform
Authors: Allen Nicole E. , Foster‐Fishman Pennie G. , Salem Deborah A. 
Published: October 2002

AbstractHuman service delivery organizations often have great difficulty implementing new service delivery technologies. This study examines the extent to which interagency service delivery teams facilitate the implementation of a popular reform that significantly challenges the status quo: family‐centered service delivery. Survey data from 121 providers representing 25 agencies within one county suggest that interagency teams may promote provider implementation of new service delivery practices. Teams members were more likely than nonteam members to implement practices consistent with family‐centered service delivery. Consumer focus group data support these findings, with consumers noting that services received from providers in the team context were more individualized, empowering, and comprehensive than the services they typically received in the county. The implications of these findings for practitioners and scholars interested in facilitating human service delivery reform are discussed. © 2002 Wiley Periodicals, Inc.
Epidermal expression of the full‐length extracellular calcium‐sensing receptor is required for normal keratinocyte differentiation
Authors: Komuves Laszlo , Oda Yuko , Tu Chia‐ling , Chang Wen Han , Ho‐Pao Chrystal L. , Mauro Theodora , Bikle Daniel D. 
Published: October 2002

AbstractThe importance of the extracellular calcium‐sensing receptor (CaR) in the stringent control of extracellular Ca2+ concentration is well established. However, the presence of CaR in tissues not directly involved in regulating mineral ion homeostasis such as the epidermis suggests a role for CaR in other cellular functions. Although extracellular Ca2+ regulates the differentiation of epidermal keratinocytes, the role of CaR in this process in the epidermis is not fully understood. In this study we showed using in situ hybridization and immunohistochemistry that CaR is expressed in suprabasal keratinocytes of the mammalian epidermis. We then evaluated the changes in epidermal keratinocyte morphology and differentiation in Casr−/− mice lacking the full‐length CaR. These mice show increased expression of an alternatively spliced form of CaR which lacks acute Ca2+‐signaling properties. The absence of the full‐length CaR in the epidermis resulted in ultrastructural changes (abnormal keratohyalin granule formation and precocious lamellar body secretion) in the terminally differentiated granular keratinocytes. Furthermore, the expression of both mRNA and protein for the calcium inducible keratinocyte differentiation markers, filaggrin and loricrin, were down‐regulated in the epidermis of Casr−/− mice, whereas the number of proliferating cells were increased even though the calcium gradient within the epidermis was enhanced. Our results demonstrate that the epidermal expression of the full‐length CaR is required for the normal terminal differentiation of keratinocytes. © 2002 Wiley‐Liss, Inc.
Ras family genes: An interesting link between cell cycle and cancer
Authors: Macaluso M. , Russo G. , Cinti C. , Bazan V. , Gebbia N. , Russo A. 
Published: October 2002

AbstractRas genes are evolutionary conserved and codify for a monomeric G protein binding GTP (active form) or GDP (inactive form). The ras genes are ubiquitously expressed although mRNA analysis suggests different level expression in tissue. Mutations in each ras gene frequently were found in different tumors, suggesting their involvement in the development of specific neoplasia. These mutations lead to a constitutive active and potentially oncogenic protein that could cause a deregulation of cell cycle. Ras protein moderates cellular responses at several mitogens and/or differentiation factors and at external stimuli. These stimuli activate a series of signal transduction pathways that either can be independent or interconnected at different points. Recent observations begin to clarify the complex relationship between Ras activation, apoptosis, and cellular proliferation. A greater understanding of these processes would help to identify the factors directly responsible for cell cycle deregulation in several tumors, moreover it would help the design of specific therapeutic strategies, for the control on the proliferation of neoplastic cells. We summarize here current knowledge of ras genes family: structural and functional characteristics of Ras proteins and their links with cell cycle and cancer. © 2002 Wiley‐Liss, Inc.
Angiopoietin‐2 plays an important role in retinal angiogenesis
Authors: Hackett Sean F. , Wiegand Stanley , Yancopoulos George , Campochiaro Peter A. 
Published: October 2002

AbstractAngiopoietin 2 (Ang2) expression in the retina is increased during physiologic and pathologic neovascularization suggesting that it may be involved. In this study, we used Ang2‐deficient mice to test that hypothesis. Mice deficient in Ang2 showed delayed and incomplete development of the superficial vascular bed of the retina, which develops primarily by vasculogenesis, and complete absence of the intermediate and deep vascular beds which develop by angiogenesis. In addition to incomplete retinal vascular development, Ang2‐deficient mice showed lack of regression of the hyaloid vasculature, resulting in a phenotype that mimics infants with persistent fetal vasculature (PFV), a relatively common congenital abnormality. Exposure to high levels of oxygen resulted in partial regression of the retinal vessels, indicating that oxygen‐induced regression of retinal vessels does not require Ang2. When these oxygen‐exposed mice with few retinal vessels were moved to room air, there was no ischemia‐induced retinal neovascularization. These data support the hypothesis that Ang2 plays a critical role in physiologic and pathologic angiogenesis, and physiologic, but not oxygen‐induced vascular regression. The data also suggest that infants with PFV should be examined for genetic modifications that would be expected to cause perturbations in Tie2 signaling. © 2002 Wiley‐Liss, Inc.
Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration
Authors: Hirata Kazuho , Kawabuchi Masaru 
Published: October 2002

AbstractThe literature concerning Schwann cells (SCs) and macrophages in myelin phagocytosis during Wallerian degeneration is reviewed. SCs carry out the first step in the removal of myelin by segmenting myelin and then incorporating the degraded myelin. The recruited macrophages then join in the myelin‐phagocytosis event, appearing to make full use of their original phagocyte abilities until the end of myelin clearance. The molecular mechanisms of the two cells underlying myelin phagocytosis are thought to be different; myelin phagocytosis by SCs being lectin‐mediated, i.e., opsonin‐independent, whereas that of macrophages is mainly opsonin‐dependent. It is important to note that SCs and macrophages cooperatively accomplish myelin phagocytosis. Microsc. Res. Tech. 57:541–547, 2002. © 2002 Wiley‐Liss, Inc.
Appraisal of Sims applicability to boron studies in plants
Authors: Dérue Cedric , Gibouin David , Verdus Marie‐Claire , Lefebvre Fabrice , Demarty Maurice , Ripoll Camille , Thellier Michel 
Published: October 2002

AbstractIn the search for a new methodological approach applicable to the determination of the still poorly known primary role of boron in plant physiology, we have undertaken to appraise the potential of the SIMS method for the analytical imaging of the boron isotopes, 10B and 11B, at physiological concentrations in plants. With our own, CAMECA IMS4F SIMS ion analyser, and using O2+ as primary ions for the detection of B+ (plus 12C+ and 40Ca+) secondary ions, we have been able to map quantitatively the two boron isotopes in control and boron‐enriched plants, to evaluate boron concentrations at the level of individual cells and to determine boron isotopic ratios. This provides the opportunity to carry out the simultaneous labeling and imaging of boron, using enrichment with the stable isotopes, 10B and 11B. The method has also the potential for the simultaneous, quantitative detection of the boron isotopes and of the borate‐binding sites in plant cells. Microsc. Res. Tech. 58:104–110, 2002. © 2002 Wiley‐Liss, Inc.