bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functions
Authors: Ahor Hubert Senanu , Vivekanandan Monika , Harelimana Jean De Dieu , Owusu Dorcas O. , Adankwah Ernest , Seyfarth Julia , Phillips Richard , Jacobsen Marc 
Published: February 2024

AbstractHost immune response is key for protection in tuberculosis, but the causative agent, Mycobacterium (M.) tuberculosis, manages to survive despite immune surveillance. Key mechanisms of immune protection have been identified, but the role of immunopathology in the peripheral blood of tuberculosis patients remains unclear. Tuberculosis immunopathology in the blood is characterised by patterns of immunosuppression and hyperinflammation. These seemingly contradictory findings and the pronounced heterogeneity made it difficult to interpret the results from previous studies and to derive implications of immunopathology. However, novel approaches based on comprehensive data analyses and revitalisation of an ancient plasma milieu in vitro assay connected inflammation with immunosuppressive factors in tuberculosis. Moreover, interrelations between the aberrant plasma milieu and immune cell pathology were observed. This review provides an overview of studies on changes in plasma milieu and discusses recent findings linking plasma factors to T‐cell and monocyte/macrophage pathology in pulmonary tuberculosis patients.
Sex‐specific gene expression in eastern oyster, Crassostrea virginica, gonad and mantle tissues
Authors: Proestou Dina A. , Delomas Thomas A. , Sullivan Mary E. , Markey Lundgren Kathryn 
Published: February 2024

AbstractThe eastern oyster (Crassostrea virginica) is a protandrous hermaphrodite of commercial importance. As with many marine invertebrates, little is known about sex determination and differentiation systems in this species. Such knowledge has important implications not only for understanding the evolution of sex but also for applied questions in aquaculture. In order to examine mechanistic differences in reproductive development between the sexes, we compared the transcriptomes of gonad and mantle tissues from six male and six female oysters. A total of 7675 transcripts were differentially expressed between male and female gonads (3936 and 3739 were upregulated in males and females, respectively). Transcripts identified include those associated with sex in other invertebrate and vertebrate species such as Dmrt1, Sox‐30, Bindin, Dpy‐30, and Histone H4 in males and Foxl2, Vitellogenin, and Bystin in females. GO terms associated with transcripts upregulated in male gonads include protein modification, reproductive process, and cell projection organization, whereas RNA metabolic process and amino acid metabolic process were associated with transcripts upregulated in females. Far fewer transcripts were differentially expressed between male and female mantle tissues, with 87 transcripts upregulated in females and 16 upregulated in males. However, 41% of transcripts identified as differentially expressed between mantle tissues were also differentially expressed between male and female gonads including Histone H4 and Bystin. This study represents the first characterization of eastern oyster male and female gonad transcriptomes. We further identify differing expression profiles between male and female mantle tissues, which provides evidence for sex‐specific functions of the mantle and suggests that this tissue could harbor biomarkers for identifying oyster sex non‐destructively.
Progenesis in dicyemids
Authors: Furuya Hidetaka 
Published: February 2024

AbstractDicyemids (Phylum Dicyemida) are the most common and characteristic endosymbiont living in the renal sac of benthic cephalopod molluscs. Precocious development of a hermaphroditic gonad occurs in the larvae and smaller juveniles of 40 dicyemid species from 17 cephalopod species so far and is the usual phenomenon in dicyemids. Based on the developmental and morphological features of precocious individuals, progenesis (a form of heterochrony) is the appropriate term for such precocious development. In general, progenetic individuals have much lower fecundity than normal ones because of their smaller body size, and therefore, it appears to be a disadvantageous reproductive trait. Nonetheless, the number of progenetic individuals consists of 30%–50% of the population, a relatively large proportion suggesting that the presence of progenetic individuals probably plays an important role in life history strategy. Precocious development significantly reduces growth time and enables early maturation. Progenetic individuals are common in short‐living cephalopod species, in which precocious development seems appropriate for dicyemids, enabling fast larval release before the end of the host's life span.
Regional detection and assessment of chilling damage on maize considering land surface temperature, crop growth status and solar radiation changes
Authors: Zhang Jingxiao , Cai Jiabing , Xu Di , Chang Hongfang , Zhang Baozhong , Wei Zheng 
Published: February 2024

AbstractIncreased frequency and severity of chilling damage events pose potential risks to crop performance and productivity due to climate change. Accurate and real‐time access to chilling damage is important for crop growth and yield stability based on field's actual environment. To precisely identify regional chilling events and evaluate the impacts on crops, this study presents a model to estimate field air temperature in view of field crop situations. Land surface temperature, enhanced vegetation index, solar‐induced chlorophyll fluorescence and solar declination were involved in the model. With field simultaneous continuous monitoring and multisource fused remote sensing data, the model was calibrated and validated in Jiefangzha Irrigation Area (JIA) and Changchun City (CC) in North China, accompanied by the determination coefficient ≥0.756, root mean square error ≤0.782°C, relative error ≤0.041 and consistency index ≥0.902. Meanwhile, sensitivities of the model factors were determined through path analysis, where the factors performed according to the order solar‐induced chlorophyll fluorescence >solar declination >land surface temperature > enhanced vegetation index. Using the validated model, chilling damage to maize was further detected in JIA and CC from 2010 to 2020. Results showed that the severity of chilling damage was greater in CC than in JIA, along with the sterile‐type occurring three events in JIA and seven in CC, while the delayed‐type only twice in JIA in 2012 and 2016, but five times in CC in 2013, 2014, 2016, 2017 and 2019, respectively, being consistent with local statistics. In response to chilling damage, enhanced vegetation index and solar‐induced chlorophyll fluorescence demonstrated the negative chilling effects on greenness and light use efficiency for fluorescence. Serious yield losses were caused, with yield‐reducing by 5.00% (Dehui, 2013), 19.00% (Jiutai, 2014), 21.65% (Suburban district, 2016), 8.83% (Shuangyang, 2017) and 2.19% (Jiutai, 2019) in CC. The linear relationship between yield and growing degree days was a bit weakened by chilling damage, with the determination coefficient varying from 0.614 to 0.531. The increasing rate of yield with growing degree days decreased from 20.365 kg/(°C·d) in non‐chilling damage years to 9.670 kg/(°C·d) in chilling damage years. These findings indicate that the presented model is especially adaptive for agricultural field environments, enabling rapid precision detection of chilling damage on crops at regional scales. It will provide references for gauging the impact of chilling damage on crops, finding efficient solutions to the stress and ensuring sustainable development of agriculture.
Understanding nurses' experience of climate change and then climate action in Western Canada
Authors: Rempel Hannah , Kalogirou Maya R. , Dahlke Sherry , Hunter Kathleen F. 
Published: February 2024

AbstractAimTo understand nurses' personal and professional experiences with the heat dome, drought and forest fires of 2021 and how those events impacted their perspectives on climate action.DesignA naturalistic inquiry using qualitative description.MethodTwelve nurses from the interior of British Columbia, Canada, were interviewed using a semi‐structured interview guide. Thematic analysis was employed. No patient or public involvement.ResultsData analysis yielded three themes to describe nurses' perspective on climate change: health impacts; climate action and system influences. These experiences contributed to nurses' beliefs about climate change, how to take climate action in their personal lives and their challenges enacting climate action in their workplace settings.ConclusionsNurses' challenges with enacting environmentally responsible practices in their workplace highlight the need for engagement throughout institutions in supporting environmentally friendly initiatives.ImpactThe importance of system‐level changes in healthcare institutions for planetary health.
Decomposing drivers in avian insectivory: Large‐scale effects of climate, habitat and bird diversity
Authors: Schillé Laura , Valdés‐Correcher Elena , Archaux Frédéric , Bălăcenoiu Flavius , Bjørn Mona Chor , Bogdziewicz Michal , Boivin Thomas , Branco Manuela , Damestoy Thomas , de Groot Maarten , Dobrosavljević Jovan , Duduman Mihai‐Leonard , Dulaurent Anne‐Maïmiti , Green Samantha , Grünwald Jan , Eötvös Csaba Béla , Faticov Maria , Fernandez‐Conradi Pilar , Flury Elisabeth , Funosas David , Galmán Andrea , Gossner Martin M. , Gripenberg Sofia , Grosu Lucian , Hagge Jonas , Hampe Arndt , Harvey Deborah , Houston Rick , Isenmann Rita , Kavčič Andreja , Kozlov Mikhail V. , Lanta Vojtech , Le Tilly Bénédicte , Lopez‐Vaamonde Carlos , Mallick Soumen , Mäntylä Elina , Mårell Anders , Milanović Slobodan , Molnár Márton , Moreira Xoaquín , Moser Valentin , Mrazova Anna , Musolin Dmitrii L. , Perot Thomas , Piotti Andrea , Popova Anna V. , Prinzing Andreas , Pukinskaya Ludmila , Sallé Aurélien , Sam Katerina , Sedikhin Nickolay V. , Shabarova Tanja , Tack Ayco J. M. , Thomas Rebecca , Thrikkadeeri Karthik , Toma Dragoș , Vaicaityte Grete , van Halder Inge , Varela Zulema , Barbaro Luc , Castagneyrol Bastien 
Published: February 2024

AbstractAimClimate is a major driver of large‐scale variability in biodiversity, as a likely result of more intense biotic interactions under warmer conditions. This idea fuelled decades of research on plant‐herbivore interactions, but much less is known about higher‐level trophic interactions. We addressed this research gap by characterizing both bird diversity and avian predation along a climatic gradient at the European scale.LocationEurope.TaxonInsectivorous birds and pedunculate oaks.MethodsWe deployed plasticine caterpillars in 138 oak trees in 47 sites along a 19° latitudinal gradient in Europe to quantify bird insectivory through predation attempts. In addition, we used passive acoustic monitoring to (i) characterize the acoustic diversity of surrounding soundscapes; (ii) approximate bird abundance and activity through passive acoustic recordings; and (iii) infer both taxonomic and functional diversity of insectivorous birds from recordings.ResultsThe functional diversity of insectivorous birds increased with warmer climates. Bird predation increased with forest cover and bird acoustic activity but decreased with mean annual temperature and functional richness of insectivorous birds. Contrary to our predictions, climatic clines in bird predation attempts were not directly mediated by changes in insectivorous bird diversity or acoustic activity, but climate and habitat still had independent effects on predation attempts.Main ConclusionsOur study supports the hypothesis of an increase in the diversity of insectivorous birds towards warmer climates but refutes the idea that an increase in diversity would lead to more predation and advocates for better accounting for activity and abundance of insectivorous birds when studying the large‐scale variation in insect‐tree interactions.
The relationships between species age and range size
Authors: Guo Qinfeng , Qian Hong , Zhang Jian , Liu Pengcheng 
Published: February 2024

AbstractSpecies range size is a central topic in macroecology, biogeography and conservation biology. Species age has been frequently regarded as a contributor to range size in previous studies on range size, but this has rarely been specifically examined. Using global data from four living terrestrial vertebrate classes (birds, mammals, reptiles and amphibians) as a case study, we examine how species range size might be related to species age at a global scale. We found statistically significant positive, albeit weak, species age–range size relationships for all four species groups. However, although the age–range relationships were positive, species with young ages had very different range sizes (both large and small), and those with very old ages always had small ranges. The observed age–range relationships were more complex than expected. The weak, rather than strong, species age–range relationships could be because our data set included all living species with different stages of their life spans (durations) that are either expanding or fluctuating or contracting, which would necessarily have minimized or cancelled species age–range relationship when all species in a group are considered collectively. Our findings shed new light on temporal dimension and macroecological correlates of species ranges.
Reversal of cardiac and renal damage in a teenager with hypertension: A case report
Authors: Du Huiyu , Gao Shilei , Dong Wenyong , Huang Qi , Qu Huiyun , Zhang Chen , Guo Linya , Liu Zhilan , Liu Min 
Published: February 2024

AbstractThe authors describe the case of a 16‐year‐old male who was incidentally found to have a blood pressure of 200/? mmHg 6 months previously due to blurred vision and was diagnosed with “high risk of hypertension grade 3, renal insufficiency, hypertensive encephalopathy, hypertensive heart disease, and fundus hemorrhage” after relevant examinations were performed. His blood pressure fluctuated around 120/90 mmHg after beginning antihypertensive treatment. While the diagnostic work‐up of his hypertension was inconclusive, he had severe hypertension with brachydactyly type E and short stature on physical examination. The patient's cardiac damage and renal insufficiency ultimately returned to normal after strict blood pressure control, suggesting that hypertension and brachydactyly syndrome alone do not cause cardiac and renal damage.
The survival of periodontally treated molars in long‐term maintenance: A systematic review and meta‐analysis
Authors: Chen Xiao , Xu Chunmei , Wu Yafei , Zhao Lei 
Published: February 2024

AbstractAimThis systematic review and meta‐analysis aimed to determine the survival of periodontally treated molars during maintenance care and identify the risk factors associated with molar loss among patients with periodontitis who received professional periodontal therapy and maintenance.Materials and MethodsLongitudinal studies with a minimum follow‐up duration of 5 years published until 28 August 2023 were retrieved from the following databases: the Cochrane Library, Embase, MEDLINE and Web of Science. All included studies reported data on molar retention. Meta‐analysis was performed using Review Manager 5.4. A modified version of the Newcastle–Ottawa Scale was used to evaluate the study quality. Statistical results of analyses of the overall survival rate and molar loss are presented as estimated standardized mean differences, whereas the results of the analyses of risk factors are presented as risk ratios with 95% confidence intervals (95% CIs).ResultsFrom among the 1323 potentially eligible reports, 41 studies (5584 patients, 29,908 molars retained at the beginning of maintenance therapy, mean follow‐up duration of 14.7 years) were included. The pooled survival rate of the molars during maintenance therapy was 82% (95% CI: 80%–84%). The average loss of molars was 0.05 per patient per year (95% CI: 0.04–0.06) among the patients receiving long‐term periodontal maintenance (PM) therapy. Fifteen factors were examined in this meta‐analysis. Six patient‐related factors (older age, lack of compliance, smoking, bruxism, diabetes and lack of private insurance) and five tooth‐related factors (maxillary location, high probing pocket depth, furcation involvement, higher mobility and lack of pulpal vitality) were identified as risk factors for molar loss during maintenance therapy.ConclusionsThe findings of the present study suggest that the long‐term retention of periodontally compromised molars can be achieved. The average number of molars lost per decade was <1 among the patients receiving long‐term PM therapy. Older age, noncompliance, smoking, bruxism, diabetes, lack of private insurance coverage, maxillary location, furcation involvement, higher mobility, increase in the probing pocket depth and loss of pulpal vitality are strong risk factors for the long‐term prognosis of molars.
Postoperative adjuvant chemotherapy is important for improving long‐term survival in patients with colorectal cancer liver metastases undergoing simultaneous resection
Authors: Zhong Wenhui , Xu Bowen , Lu Yiming , Chang Jianping , Xu Lin , Zhao Hong , Che Xu 
Published: February 2024

AbstractBackground and AimA growing number of studies have demonstrated that neoadjuvant chemotherapy can improve the prognosis of patients with resectable colorectal liver metastases (CRLM). However, the routine use of postoperative adjuvant chemotherapy (POAC) for patients with CRLM after simultaneous resection remains controversial. This retrospective study investigated the impact of POAC on outcomes in patients with CRLM who underwent simultaneous resection of colorectal cancer tumors and liver metastases using propensity score matching (PSM) analysis.MethodsFrom January 2009 to November 2020, patients with CRLM who underwent simultaneous resection were retrospectively enrolled. The confounding factors and selection bias were adjusted by 2:1 PSM. Patients were stratified into the POAC and non‐POAC groups. Kaplan–Meier curves were utilized to compare overall survival (OS) and progression‐free survival (PFS) between the groups. Univariate and multivariate Cox regression analyses were used to identify independent clinicopathological factors before and after PSM analysis. The utility of the model was evaluated using receiver operating characteristic (ROC) and calibration curves after PSM analysis.ResultsIn total, 478 patients with resectable CRLM were enrolled and assigned to the POAC (n = 212, 60.9%) or non‐POAC group (n = 136, 39.1%). After 2:1 PSM, there was no significant bias between the groups. Kaplan–Meier survival analysis revealed a significant effect of POAC on OS (P < 0.001) but not PFS. Multivariate Cox regression analysis identified T stage (T3–T4), lymph node metastasis, radiofrequency ablation during surgery, operative time ≥ 325 min, and the receipt of postoperative adjuvant chemotherapy (hazard ratio = 0.447, 95% confidence interval = 0.312–0.638, P < 0.001) as independent prognostic factors for OS. The areas under the ROC curves for the nomogram model for predicting 1‐, 3‐, and 5‐year survival were 0.653, 0.628, and 0.678, respectively. Subgroups analysis suggested that POAC can enhance OS in patients with resectable CRLM with either low (1–2, P < 0.001) or high clinical risk scores (3–5, P = 0.020).ConclusionsOverall, this study identified POAC as a prognostic factor to predict OS in patients with CRLM undergoing simultaneous resection.
Diagnostic algorithm for neonatal intrahepatic cholestasis integrating single‐gene testing and next‐generation sequencing in East Asia
Authors: Hahn Jong Woo , Lee Heerah , Shin MinSoo , Seong Moon Woo , Moon Jin Soo , Ko Jae Sung 
Published: February 2024

AbstractBackground and AimAdvances in molecular genetics have uncovered causative genes responsible for neonatal cholestasis. Panel‐based next‐generation sequencing has been used clinically in infants with neonatal cholestasis. We aimed to evaluate the clinical application of single‐gene testing and next‐generation sequencing and to develop a diagnostic algorithm for neonatal intrahepatic cholestasis.MethodsFrom January 2010 to July 2021, patients suspected of having neonatal intrahepatic cholestasis were tested at the Seoul National University Hospital. If there was a clinically suspected disease, single‐gene testing was performed. Alternatively, if it was clinically difficult to differentiate, a neonatal cholestasis gene panel test containing 34 genes was performed.ResultsOf the total 148 patients examined, 49 (33.1%) were received a confirmed genetic diagnosis, including 14 with Alagille syndrome, 14 with neonatal intrahepatic cholestasis caused by citrin deficiency, 7 with Dubin–Johnson syndrome, 5 with arthrogryposis‐renal dysfunction‐cholestasis syndrome, 5 with progressive familial intrahepatic cholestasis type II, 1 with Rotor syndrome, 1 with Niemann‐Pick disease type C, 1 with Kabuki syndrome, and 1 with Phenylalanyl‐tRNA synthetase subunit alpha mutation. Sixteen novel pathogenic or likely pathogenic variants of neonatal cholestasis were observed in this study. Based on the clinical characteristics and laboratory findings, we developed a diagnostic algorithm for neonatal intrahepatic cholestasis by integrating single‐gene testing and next‐generation sequencing.ConclusionsAlagille syndrome and neonatal intrahepatic cholestasis caused by citrin deficiency were the most common diseases associated with genetic neonatal cholestasis. Single‐gene testing and next‐generation sequencing are important and complementary tools for the diagnosis of genetic neonatal cholestasis.
Integrative regulatory mechanisms of stomatal movements under changing climate
Authors: Zhang Jingbo , Chen Xuexue , Song Yajing , Gong Zhizhong 
Published: February 2024

ABSTRACTGlobal climate change‐caused drought stress, high temperatures and other extreme weather profoundly impact plant growth and development, restricting sustainable crop production. To cope with various environmental stimuli, plants can optimize the opening and closing of stomata to balance CO2 uptake for photosynthesis and water loss from leaves. Guard cells perceive and integrate various signals to adjust stomatal pores through turgor pressure regulation. Molecular mechanisms and signaling networks underlying the stomatal movements in response to environmental stresses have been extensively studied and elucidated. This review focuses on the molecular mechanisms of stomatal movements mediated by abscisic acid, light, CO2, reactive oxygen species, pathogens, temperature, and other phytohormones. We discussed the significance of elucidating the integrative mechanisms that regulate stomatal movements in helping design smart crops with enhanced water use efficiency and resilience in a climate‐changing world.