bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with the Number of Injured and Fatalities in Motor Vehicle Intentional Mass-Casualty Incidents: A Timely Aid for Scaling the Emergency Response
Authors: Valiño Eva Maria , Castro-Delgado Rafael , Sola Muñoz Silvia , Lynam Barry , Castro Pedro 
Published: January 2024

AbstractIntroduction:Intentional mass-casualty incidents (IMCIs) involving motor vehicles (MVs) as weapons represent a growing trend in Western countries. This method has resulted in the highest casualty rates per incident within the field of IMCIs. Consequently, there is an urgent requirement for a timely and accurate casualty estimation in MV-induced IMCIs to scale and adjust the necessary health care resources.Study Objective:The objective of this study is to identify the factors associated with the number of casualties during the initial phase of MV-IMCIs.Methods:This is a retrospective, observational, analytical study on MV-IMCIs world-wide, from 2000-2021. Data were obtained from three different sources: Targeted Automobile Ramming Mass-Casualty Attacks (TARMAC) Attack Database, Global Terrorism Database (GTD), and the vehicle-ramming attack page from the Wikipedia website. Jacobs’ formula was used to estimate the population density in the vehicle’s route. The primary outcome variables were the total number of casualties (injured and fatalities). Associations between variables were analyzed using Spearman’s correlation coefficient and simple linear regression.Results:Forty-six MV-IMCIs resulted in 1,636 casualties (1,430 injured and 206 fatalities), most of them caused by cars. The most frequent driving pattern was accelerating whilst approaching the target, with an average speed range between four to 130km/h and a distance traveled between ten to 2,260 meters. The people estimated in the MV-IMCI scenes ranged from 36-245,717. A significant positive association was found of the number affected with the estimated crowd in the scene (R2: 0.64; 95% CI, 0.61-0.67; P <.001) and the average vehicle speed (R2: 0.42; 95% CI, 0.40-0.44; P = .004).Conclusion:The estimated number of people in the affected area and vehicle’s average speed are the most significant variables associated with the number of casualties in MV-IMCIs, helping to enable a timely estimation of the casualties.
Monitoring and management of common property resources: empirical evidence from forest user groups in Ethiopia
Authors: Kahsay Goytom Abraha , Bulte Erwin 
Published: January 2024

AbstractThe presence of monitoring institutions affects quality and effort of leaders. We investigate the effect of intensified monitoring on the ability and effort of leaders for a sample of forest user groups in Ethiopia, and find experimental and non-experimental evidence of an important trade-off: monitoring increases leaders' effort but lowers their quality in terms of education and experience. This effort–ability trade-off only occurs in the presence of alternative income opportunities (affecting the opportunity cost of time) and only among a subsample of leaders with low prosocial motivation. For our context, we document that the net effect of monitoring on economic outcomes is positive.
International Perception and Local Pride in Smart City Development: The Case of Hong Kong
Authors: Lai Calvin Ming Tsun , Cole Alistair 
Published: January 2024

AbstractLocal citizens’ perceptions of their own cities are often neglected when assessing cities’ performance. Using the perceived international image and collective pride in Hong Kong as the entry point, this article aims to discover the relationship between citizens’ trust in public authorities and urban technologies. Four angles of investigation are developed: the impact of cities’ promotion of their international image on local pride; the attitudinal and demographic characteristics of proud citizens; the linkage of local pride with public trust, and digital trust. This article uses data from a Hong Kong-based territory-wide survey in 2021 to conduct the analysis. The result suggests that public trust is an elemental factor having a positive relationship with collective pride and digital trust in Hong Kong. This article also identifies the group of citizens with the least pride. Regaining the citizen's trust is the best remedy for facilitating smart city development.
Two Laterally Distant TGFs From Negative Cloud‐To‐Ground Strokes in Uchinada, Japan
Authors: Ortberg John , Smith David M. , Kamogawa Masashi , Dwyer Joseph , Bowers Gregory , Chaffin Jeffrey , Lapierre Jeff , Wang Daohong , Wu Ting , Suzuki Tomoyuki 
Published: January 2024

AbstractWe observed two Terrestrial Gamma‐ray Flashes (TGFs) in Uchinada, Japan associated with negative cloud‐to‐ground lightning strokes exactly 1 year apart on 18 December 2020 and 2021. The events were remarkable for their lateral distance from the associated strokes—each about 5 km away from the detector site. Not only was that lateral distance remarkable on its own for a ground based detection, but the low‐altitude profile of winter thunderstorms in Japan would suggest the detections occurred at unprecedented nadir angles—73.3° off axis for the 2020 event with the standard assumption of a vertically oriented TGF. Unsurprisingly, Monte Carlo simulations of the straightforward interpretation of these events yield fluences 2 orders of magnitude lower than observed data. We investigate a variety of ways to attempt to resolve the contradiction between expected and observed behavior.
Evolution of a Surge Cycle of the Bering‐Bagley Glacier System From Observations and Numerical Modeling
Authors: Trantow Thomas , Herzfeld Ute C. 
Published: January 2024

AbstractThe Bering‐Bagley Glacier System (BBGS), Alaska, Earth's largest temperate surging glacier, surged in 2008–2013. We use numerical modeling and satellite observations to investigate how surging in a large and complex glacier system differs from surging in smaller glaciers for which our current understanding of the surge phenomenon is based. With numerical simulations of a long quiescent phase and a short surge phase in the BBGS, we show that surging is more spatiotemporally complex in larger glaciers with multiple reservoir areas forming during quiescence which interact in a cascading manner when ice accelerates during the surge phase. For each phase, we analyze the simulated elevation‐change and ice‐velocity pattern, infer information on the evolving basal drainage system through hydropotential analysis, and supplement these findings with observational data such as CryoSat‐2 digital elevation maps. During the quiescent simulation, water drainage paths become increasingly lateral and hydropotential wells form indicating an expanding storage capacity of subglacial water. These results are attributed to local bedrock topography characterized by large subglacial ridges that dam the down‐glacier flow of ice and water. In the surge simulation, we model surge evolution through Bering Glacier's trunk by imposing a basal friction representation that mimics a propagating surge wave. As the surge progresses, drainage efficiency further degrades in the active surging‐zone from its already inefficient, end‐of‐quiescence state. Results from this study improve our knowledge of surging in large and complex systems which generalizes to glacial accelerations observed in outlet glaciers of Greenland, thus reducing uncertainty in modeling sea‐level rise.
NON-pharmacological Approach Less Invasive Surfactant Administration (NONA-LISA) trial: protocol for a randomised controlled trial
Authors: Breindahl Niklas , Henriksen Tine Brink , Heiring Christian , Bay Emma Therese , Haaber Jannie , Salmonsen Tenna Gladbo , Carlsen Emma Louise Malchau , Zachariassen Gitte , Agergaard Peter , Viuff Anne-Cathrine Finnemann , Bender Lars , Grønnebæk Tolsgaard Martin , Aunsholt Lise 
Published: January 2024

Abstract
Introduction
Using pre-procedure analgesia with the risk of apnoea may complicate the Less Invasive Surfactant Administration (LISA) procedure or reduce the effect of LISA.

Methods
The NONA-LISA trial (ClinicalTrials.gov, NCT05609877) is a multicentre, blinded, randomised controlled trial aiming at including 324 infants born before 30 gestational weeks, meeting the criteria for surfactant treatment by LISA. Infants will be randomised to LISA after administration of fentanyl 0.5–1 mcg/kg intravenously (fentanyl group) or isotonic saline solution intravenously (saline group). All infants will receive standardised non-pharmacological comfort care before and during the LISA procedure. Additional analgesics will be provided at the clinician’s discretion. The primary outcome is the need for invasive ventilation, meaning mechanical or manual ventilation via an endotracheal tube, for at least 30 min (cumulated) within 24 h of the procedure. Secondary outcomes include the modified COMFORTneo score during the procedure, bronchopulmonary dysplasia at 36 weeks, and mortality at 36 weeks.

Discussion
The NONA-LISA trial has the potential to provide evidence for a standardised approach to relief from discomfort in preterm infants during LISA and to reduce invasive ventilation. The results may affect future clinical practice.

Impact

Pre-procedure analgesia is associated with apnoea and may complicate procedures that rely on regular spontaneous breathing, such as Less Invasive Surfactant Administration (LISA).

This randomised controlled trial addresses the effect of analgesic premedication in LISA by comparing fentanyl with a placebo (isotonic saline) in infants undergoing the LISA procedure. All infants will receive standardised non-pharmacological comfort.

The NONA-LISA trial has the potential to provide evidence for a standardised approach to relief from discomfort or pain in preterm infants during LISA and to reduce invasive ventilation. The results may affect future clinical practice regarding analgesic treatment associated with the LISA procedure.
Pediatric invasive device utility and harm: a multi-site point prevalence survey
Authors: Takashima Mari , Gibson Victoria , Borello Eloise , Galluzzo Lily , Gill Fenella J. , Kinney Sharon , Newall Fiona , Ullman Amanda J. 
Published: January 2024

Abstract
Background and aims
Invasive devices are widely used in healthcare settings; however, pediatric patients are especially vulnerable to invasive device-associated harm. This study aimed to explore invasive device utility, prevalence, harm, and clinical practice across three Australian pediatric tertiary hospitals.

Methods
In 2022–2023, a multi-center, observational, rolling-point-prevalence survey was conducted. Fifty-per-cent of inpatients were systemically sampled by random allocation. Patients with devices were then followed for up to 3-days for device-related complications/failures and management/removal characteristics.

Results
Of the 285 patients audited, 78.2% had an invasive device (n = 412 devices), with a median of 1 device-per-patient (interquartile range 1–2), with a maximum of 13 devices-per-patient. Over half of devices were vascular access devices (n = 223; 54.1%), followed by gastrointestinal devices (n = 112; 27.2%). The point-prevalence of all device complications on Day 0 was 10.7% (44/412 devices) and period-prevalence throughout the audit period was 27.7% (114/412 devices). The period-prevalence of device failure was 13.4% (55/412 devices).

Conclusions
The study highlighted a high prevalence of invasive devices among hospitalized patients. One-in-ten devices failed during the audit period. These findings underscore the need for vigilant monitoring and improved strategies to minimize complications and enhance the safety of invasive devices in pediatric hospital settings.

Impact

A high prevalence of invasive devices among hospitalized patients was reported. Of the 285 patients audited, almost 80% had an invasive device (total 412 devices), with a median of 1 device-per-patient and a maximum of 13 devices-per-patient.

The most common devices used in pediatric healthcare are vascular access devices (n = 223; 54.1%), however, 16% (n = 36) of these devices failed, and one-third had complications.

The point prevalence of all device complications at day 0 was 10.7% (44 out of 412 devices), with a period prevalence of 27.7% (114 out of 412 devices) throughout the audit period.
Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation
Authors: Yan Xuejing , Wu Shen , Liu Qian , Cheng Ying , Teng Yufei , Ren Tianmin , Zhang Jingxue , Wang Ningli 
Published: January 2024

AbstractGlaucoma is a highly heritable disease, and myocilin was the first identified causal and most common pathogenic gene in glaucoma. Serine-to-proline mutation at position 341 of myocilin (MYOCS341P) is associated with severe glaucoma phenotypes in a five-generation primary open-angle glaucoma family. However, the underlying mechanisms are underexplored. Herein, we established the MYOCS341P transgenic mouse model and characterized the glaucoma phenotypes. Further, we systematically explored the functional differences between wild-type and MYOCS341P through immunoprecipitation, mass spectrometry, and RNA-seq analyses. We found that MYOCS341P transgenic mice exhibit glaucoma phenotypes, characterized by reduced aqueous humor outflow, elevated intraocular pressure, decreased trabecular meshwork (TM) cell number, narrowed Schlemm’s canal, retinal ganglion cell loss, and visual impairment. Mechanistically, the secretion of dysfunctional MYOCS341P accumulated in the endoplasmic reticulum (ER), inducing ER stress and dysregulation of autophagy, thereby promoting TM cell death. We describe an effective transgenic model for mechanistic studies and the screening of therapeutic targets. Our data generated from high-throughput analyses help elucidate the mechanism underlying mutant MYOC-related glaucoma.
Selective synthesis of α-vinyl-ω-vinylidene-oligoisoprene as a macromonomer via ethenolysis of polyisoprene
Authors: Tanaka Ryo , Shimmei Akane , Otsuka Riki , Nakayama Yuushou , Shiono Takeshi 
Published: January 2024

AbstractOligoisoprene macromonomer, which bears a terminal vinyl group, was prepared by the metathesis degradation of high-molecular-weight polyisoprene with ethylene for coordination polymerization. The ethenolysis of polyisoprene using the 2nd-generation Grubbs catalyst (G2) at ambient pressure gave heterotelechelic (α-vinyl-ω-vinylidene) oligoisoprene, keeping the stereoregularity in high yield, whereas the 1st generation Grubbs catalyst was immediately deactivated. In such metathesis degradation, an intramolecular side reaction giving cyclic oligomers may be competitive, but ethenolysis proceeded with high selectivity, probably because of the least steric effect of ethylene. The ethenolysis is also applicable for the degradation of natural rubber-derived polyisoprene, although the catalytic activity decreased. The prepared oligoisoprene macromonomer was successfully copolymerized with ethylene using a phenoxyimine-ligated titanium catalyst, and the reactivity of the macromonomer was almost the same as that of 1-hexadecene. The oligoisoprene-grafted polyethylene showed a typical stress‒strain curve, of which the tensile modulus and yielding stress are comparable to those of linear low-density polyethylene.
Sensorimotor adaptation of locomotor synergies to gravitational constraint
Authors: Guillaud Etienne , Leconte Vincent , Doat Emilie , Guehl Dominique , Cazalets Jean-René 
Published: January 2024

AbstractThis study investigates the impact of gravity on lower limb muscle coordination during pedaling. It explores how pedaling behaviors, kinematics, and muscle activation patterns dynamically adapts to changes in gravity and resistance levels. The experiment was conducted in parabolic flights, simulating microgravity, hypergravity (1.8 g), and normogravity conditions. Participants pedaled on an ergometer with varying resistances. The goal was to identify potential changes in muscle synergies and activation strategies under different gravitational contexts. Results indicate that pedaling cadence adjusted naturally in response to both gravity and resistance changes. Cadence increased with higher gravity and decreased with higher resistance levels. Muscular activities were characterized by two synergies representing pull and push phases of pedaling. The timing of synergy activation was influenced by gravity, with a delay in activation observed in microgravity compared to other conditions. Despite these changes, the velocity profile of pedaling remained stable across gravity conditions. The findings strongly suggest that the CNS dynamically manages the shift in body weight by finely tuning muscular coordination, thereby ensuring the maintenance of a stable motor output. Furthermore, electromyography analysis suggest that neuromuscular discharge frequencies were not affected by gravity changes. This implies that the types of muscle fibers recruited during exercise in modified gravity are similar to those used in normogravity. This research has contributed to a better understanding of how the human locomotor system responds to varying gravitational conditions, shedding light on the potential mechanisms underlying astronauts’ gait changes upon returning from space missions.
Diffuse reflectance spectroscopy and imaging for non-invasive objective assessment of genitourinary syndrome of menopause: a pilot study
Authors: Dinish U. S. , Logan Susan , Balasundaram Ghayathri , Xinhui Valerie Teo , Vinod Ram Keertana , Ruochong Zhang , Renzhe Bi , Silvani Steffie , Hua Cheng Kee , Xia Xu , Giap Hean Goh , Choolani Mahesh , Olivo Malini 
Published: January 2024

AbstractThe genitourinary symptom of menopause (GSM) affects up to 65% of women, resulting in symptoms such as vulvovaginal dryness, discomfort, and dysuria, which significantly impacts quality of life. The current assessment methods rely on subjective questionnaires that can be influenced by individual differences, as well as invasive measurements that are time-consuming and not easily accessible. In this study, we explore the potential of a non-invasive and objective assessment tool called diffuse reflectance spectroscopy and imaging (DRSI) to evaluate tissue chromophores, including water, lipid, oxyhemoglobin, and deoxyhemoglobin. These measurements provide information about moisture content, lipid levels, oxygen saturation, and blood fraction, which can serve as surrogate markers for genital estrogen levels. Our findings reveal distinct differences in these chromophores among pre, peri, and postmenopausal subjects. By using lipid and blood fraction tissue chromophores in a K-Nearest Neighbour classifier model, we achieved a prediction accuracy of 65% compared to vaginal maturation index (VMI) that is clinically used to assess estrogen-related hormonal changes. When age was included as the third feature, the accuracy increased to 78%. We believe that by refining the study protocol and configuring the fiber probe to examine tissue chromophores both in the superficial vulva skin for epidermal water content and the deeper layers, DRSI has the potential to provide objective diagnosis and aid in monitoring the treatment outcome of GSM.
Lactate-induced autophagy activation: unraveling the therapeutic impact of high-intensity interval training on insulin resistance in type 2 diabetic rats
Authors: Pirani Hossein , Soltany Afsaneh , Hossein Rezaei Maryam , Khodabakhshi Fard Adeleh , Nikooie Rohollah , Khoramipoor Kimya , Chamari Karim , Khoramipour Kayvan 
Published: January 2024

AbstractImpaired autophagy is a hallmark of diabetes. The current study proposed to investigate if high intensity interval training (HIIT) induced lactate accumulation could stimulate autophagy in type 2 diabetic male rats. 28 male Wistar rats were randomly assigned into four groups: Healthy Control (CO), Diabetes Control (T2D), Exercise (EX), and Diabetes + Exercise (T2D + EX). Diabetes was induced by feeding high-fat diet and administrating single dose of streptozotocin (35 mg/kg). After becoming diabetic, the animals in the exercise groups (EX and T2D + EX) performed an eight-week HIIT (4–10 interval, 80–100% Vmax, 5 days per week). Serum levels of lactate, glucose and insulin as well as the levels of lactate, pyruvate, lactate transporter monocarboxylate transporter 1 (MCT1), phosphorylated mitogen-activated protein kinases (p-MAP 1 and 2), phosphorylated extracellular signal-regulated protein kinases 1 and 2 (p-ERK 1 and 2), mammalian target of rapamycin (p-mTOR), ribosomal protein S6 kinase beta-1 (p-70S6k), p90 ribosomal S6 kinases (p-90RSK), autophagy related 7 (ATG7), Beclin-1, microtubule-associated protein 1A/1B, and 2A/2B -light chain 3 levels (LC3-I), (LC3- II), (LC3I/LC3II) in soleus muscle were measured. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and serum glucose was lower in T2D + EX compared to T2D group (P < 0.0001). While serum and soleus muscle levels of lactate was not different between T2D and T2D + Ex, the levels of Pyruvate (P < 0.01), MCT1, p-ERK1/2, p-mTOR, p70S6k, P-90RSK, ATG7, LC3-II, and LC3-II/LC3I ratios were higher in T2D + EX compared to T2D group (P < 0.0001). We concluded that eight weeks of high-intensity interval training could activated ERK/P90SRK while inhibiting mTOR/P70S6K signaling pathway in lactate dependent manner. It means increased autophagy which resulted in improve insulin resistance (IR) and reduce blood glucose.
Probiotic consortium modulating the gut microbiota composition and function of sterile Mediterranean fruit flies
Authors: Haytham Hamden , Kamel Charaabi , Wafa Djobbi , Salma Fadhel , Naima Bel Mokhtar , George Tsiamis , Ameur Cherif , Msaad Guerfali Meriem 
Published: January 2024

AbstractThe sterile insect technique (SIT) remains a successful approach in managing pest insects. However, the long-term mass rearing and sterilizing radiation associated with SIT have been observed to induce physiological and ecological fitness decline in target insects. This decline may be attributed to various factors, including commensal microbiota dysbiosis, selection procedures, loss of heterozygosity, and other complex interactions.. There is evidence that the bacterial symbiont of insects may play critical roles in digestion, development, reproduction, and behavior. Probiotics are an increasingly common approach for restoring the intestinal microbiota structure and fitness parameters of sterile insects, particularly in the Vienna 8 genetic sexing strain (V8-GSS) of the Mediterranean fruit fly (medfly), Ceratitis capitata. Here, we explore the influence of the previously isolated bacterial strain, Lactococcus lactis, Enterobacter sp., and Klebsiella oxytoca, administration as probiotic consortia (LEK-PC) to the larvae and/or adult diet over the course of 20 rearing generations on fitness parameters. The experiment was carried out in four colonies: a control colony (C), one to which probiotics were not added, one to which probiotics were added to the larval medium (L+), one to which probiotics were added to the adult medium (A+), and one to which probiotics were added to both the larval and adult mediums (AL+). Emergence, flight ability, survival under stress conditions, and mating competitiveness, were all significantly improved by the LEK-PC treatment independently of the administration stage. The intestinal microbiota structure of various medfly V8-GSS colonies also underwent a significant shift, despite the fact that the core microbial community was unaffected by the LEK-PC administration stage, according to 16S metagenomics sequencing. Comparison of the metabolic function prediction and associated carbohydrate enzymes among colonies treated with “LEK-PC” showed an enrichment of metabolic functions related to carbohydrates, amino acids, cofactors, and vitamins metabolism, as well as, glycoside hydrolase enzymes in the AL+ colony compared to the control. This study enriches the knowledge regarding the benefits of probiotic treatment to modulate and restore the intestinal microbiota of C. capitata sterile males for a better effectiveness of the SIT.