bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Trajectory Tracking Control of a Differentially Flat Overhead Crane Using Sliding Mode
Authors: Finta Barnabás , Kiss Bálint 
Published: January 2024

The control of overhead cranes is a benchmark problem, since it is an underactuated mechanism and its mathematical model is nonlinear. During operation the mass of the load is unknown, representing an uncertainty in the inertial parameters, which requires robustness of the controlled system. Our paper proposes a novel robust control method, that combines the differentially flat property of the dynamics with the robustness of the sliding mode control. The sliding surface is constructed to ensure the tracking of the configuration variables whose accelerations is calculated using the flatness property of the dynamic model. This formulation also allows achieving the matching conditions of the parameter uncertainties. Considering a simplified overhead crane model where the load motion is restricted in a vertical plane, two sliding surfaces are defined for the rope angle and rope length, since the cart position can be calculated from the previous two. The suggested control method is successfully validated in simulations as well as using a reduced-size overhead crane. For the real crane, the rope angle was estimated by utilizing the dynamical model, which uses the estimated cart acceleration.
Intervención fisioterapéutica en pacientes con quemaduras, una revisión narrativa
Authors: Vinueza Orozco Ernesto Fabián , López Merino María Fernanda , Robalino Morales Liliana Margot , Rodríguez Espinosa Jorge Ricardo 
Published: January 2024

Introducción: se considera como quemadura al daño que sufre la piel y tejidos frente a un estímulo caliente, se dividen dependiendo el daño, que va desde el 1er grado hasta el 4to grado. En Ecuador, se realizó un estudio en el Hospital Baca Ortiz de la ciudad de Quito donde existe una referencia que, de un total de 343 pacientes pediátricos con quemaduras. Las cicatrices por quemaduras siguen siendo un problema crónico después de lesiones por quemaduras, y las cicatrices sintomáticas se desarrollan con mayor frecuencia después de quemaduras profundas o de gran superficie que tardan más de tres semanas en sanar. Se consideró a la rehabilitación era un tratamiento posterior, pero ahora se ha demostrado que es eficaz y beneficiosa para una variedad de enfermedades y trastornos y se reconoce como un aspecto esencial del buen pronóstico funcional de los pacientes. Objetivo: Revisar la evidencia científica disponible sobre la intervención fisioterapéutica temprana para la recuperación y rehabilitación del paciente quemado. Metodología: Se realizó una revisión narrativa de la literatura desde perspectiva profesional Fisioterapeuta – Psicología. La revisión bibliográfica de documentos en las bases de datos Scopus, Google Scholar y SciELO. Fueron seleccionaron un total de 20 artículos, en inglés y español, se emplearon los descriptores Fisioterapia, kinesioterapia, ejercicio y quemaduras. Discusión: Se proponen protocolos y pautas de tratamiento, desde las quemaduras leves hasta graves que requieren de hospitalización e intervención quirúrgica con un equipo de salud multidisciplinario para que el paciente tenga atención integral. Conclusión: Podemos sostener que el tratamiento de fisioterapia y rehabilitación en pacientes con quemaduras independiente del grado es oportuno y eficaz siempre y cuando tenga la valoración respectiva y el enfoque rehabilitador como puede ser recuperar rangos de movilidad o a su vez mejorar calidad de vida en los pacientes desde el punto de vista rehabilitación integral con equipo multidisciplinario. Área de estudio general: Fisioterapia. Área de estudio específica: Tratamiento Rehabilitador en pacientes con quemaduras. Tipo de estudio: Artículo Original.
Рекомендації щодо запровадження системи моніторингу прикордонного простору
Authors: Федик Андрій , Калюжний Володимир 
Published: January 2024

Мета роботи: формулювання змісту рекомендацій щодо запровадження системи моніторингу прикордонного простору.
Метод дослідження: аналіз, декомпозиція та синтез.
Результати дослідження: визначено, основними завданнями інженерно-технічного облаштування кордону є: забезпечення дистанційного моніторингу технічного оснащення прикордонного району, ускладнення незаконного перетину кордону та забезпечення його контролю, охорони відповідного прикордонного підрозділу на кордоні від видів засобів травмування; забезпечення можливих умов дій своїх сил (військ) та застосування засобів.
Теоретична цінність дослідження: полягає у компіляції популярних наукових поглядів із проблеми дослідження.
Практична цінність дослідження: полягає у тому, що сформульовано зміст рекомендацій щодо запровадження системи моніторингу прикордонного простору.
Тип статті: теоретичний.
Порівняння законів розподілу (моделей відмов) для опису процесів, що відбуваються у математичній моделі експлуатації (зберігання) засобів ураження на стадіях життєвого циклу “використання” та “підтримка”
Authors: Куртсеітов Тимур , Копашинський Сергій , Яблонський Петро 
Published: January 2024

Мета роботи: дослідити вплив параметрів моделей відмов на показник ефективності технічного обслуговування. Це дослідження може бути використано організаторами виробництва та науковим персоналом при виборі моделі відмов для проведення власних досліджень у сфері озброєння та військової техніки.
Метод: основними методами дослідження є: статистичного аналізу, чисельний метод, порівняльного аналізу.
Результати дослідження: запропоновані рекомендації щодо вибору моделі відмов дозволяють обґрунтувати вибір закону розподілу та, на відмінну від відомих, базується на дослідженні впливу законів розподілу на комплексний показник надійності – коефіцієнт технічного використання, що дозволяє обґрунтувати доцільність використання дифузійних законів розподілу у якості моделі відмов відповідних зразків засобів ураження однократного застосування, які містять різнорідні складові частини, а саме: радіоелектронні, електромеханічні, гідравлічні та гумо-технічні.
Теоретична цінність дослідження: в роботі представлено спосіб порівняння законів розподілу (моделей відмов) для опису процесів, що відбуваються у математичній моделі експлуатації (зберігання) засобів ураження на стадіях життєвого циклу “використання” та “підтримка”. При цьому для опису процесів, що відбуваються у математичній моделі, застосовується напівмарковський випадковий процес. В якості комплексного показника надійності технічної експлуатації авіаційних засобів ураження обрано коефіцієнт технічного використання, а також визначено критерії ефективності. Проведенні розрахунки свідчать про перевагу дифузійних законів перед експоненціальним, що в свою чергу підвищує точність подальших розрахунків з використанням дифузійних розподілів.
Тип статті: науково-практична.
Una interpretación del débil crecimiento de la economía alemana en el período 1995-2007
Authors: Luque de Haro Víctor , Palazuelos Manso Enrique 
Published: January 2024

Este trabajo se propone explica las características del proceso de transformación productiva y de lento crecimiento económico de Alemania entre 1995 y 2007 mediante el análisis de un conjunto de variables que vinculan la evolución de la demanda y la distribución del ingreso con la estructura productiva. El análisis combina el estudio del comportamiento económico agregado con la desagregación por grupos de ramas productivos. De esta manera se pueden constatar las grandes diferencias que registran casi todas las variables analizadas entre, por un lado, las ramas de mayor intensidad tecnológica y el resto. El análisis permite formular una explicación de la forma en que la economía alemana experimentó a la vez una profunda transformación productiva y un lento crecimiento durante el período anterior a la crisis financiera.
Durvalumab with or without tremelimumab for patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a systematic review and meta-analysis
Authors: Han Xiao , Zhang Haidong , Sun Kai , Li Jing , Wu Wanjuan , Liu Kai , Yu Zhenkun 
Published: January 2024

ObjectiveHead and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent cancer worldwide, significantly impacting patients’ quality of life. Immune checkpoint inhibitors (ICI) have been employed in the treatment of recurrent/metastatic (R/M)-HNSCC patients. This meta-analysis aims to assess the efficacy and safety of durvalumab monotherapy compared to the combination of durvalumab and tremelimumab in R/M-HNSCC patients.MethodsRelevant studies were systematically searched in PubMed, Embase, and Cochrane Library databases. All articles comparing durvalumab monotherapy with the combination with durvalumab and tremelimumab in R/M-HNSCC treatment were included. Additionally, the references of identified studies were screened if necessary.ResultA total of 1298 patients from three studies comparing durvalumab with durvalumab and tremelimumab in treating R/M-HNSCC were include in this meta-analysis. Our findings revealed no significant difference in objective response rate (ORR) [odds ratio (OR): 1.15, 95% confidence interval (CI): 0.85 to 1.56, P = 0.36] and disease control rate (DCR) (OR=1.08, 95%CI: 0.86 to 1.37, P = 0.51). Similar outcomes were observed in overall survival (OS), progression-free survival (PFS), and duration of response (DoR). Regarding safety, there was no significant difference in the incidence of treatment-related adverse events (trAEs) between the two groups (OR=1.26, 95%CI: 0.81 to 1.94, P = 0.30). However, patients treated with the combination therapy exhibited a higher incidence of grade 3-4 trAEs (OR=1.93, 95%CI: 1.36 to 2.73, P = 0.0002) and a greater likelihood of discontinuing treatment due to trAEs (OR=2.07, 95%CI: 1.12 to 3.85, P = 0.02). There was no significant difference in the occurrence of severe trAEs leading to death (OR=1.36, 95%CI: 0.47 to 3.96, P = 0.57).ConclusionThis meta-analysis suggests that R/M-HNSCC patients receiving the combination of durvalumab and tremelimumab may achieve comparable outcomes in terms of ORR, DCR, OS, PFS, and DoR, without significant differences. However, the combination therapy is associated with a higher incidence of grade 3-4 trAEs and an increased likelihood of treatment discontinuation due to trAEs. These findings highlight the need for cautious consideration of the combination of durvalumab and tremelimumab in R/M-HNSCC patients, which should be further evaluated in high-quality studies.
Causal effects from inflammatory bowel disease on liver function and disease: a two-sample Mendelian randomization study
Authors: Shu Yufeng , Yang Bocheng , Liu Xuanyou , Xu Meihua , Deng Chao , Wu Hao 
Published: January 2024

BackgroundAccumulating evidence has shown that patients with inflammatory bowel disease (IBD) have liver function abnormalities and are susceptible to liver diseases. However, the existence of a causal relationship between IBD and liver function or disease remains unclear.MethodsA two-sample Mendelian randomization (MR) analysis was performed using genetic associations from publicly available genome-wide association studies (GWAS). These associations encompass ulcerative colitis (UC), Crohn’s disease (CD), liver function traits, and liver disease phenotypes. The liver function traits comprised hepatic biochemistries, percent liver fat, and liver iron content from the UK Biobank. Furthermore, the liver disease phenotypes included cholelithiasis, non-alcoholic fatty liver disease (NAFLD), primary sclerosing cholangitis (PSC), and primary biliary cholangitis (PBC) in cohorts of European ancestry. The primary estimation used the inverse-variance weighted method, with GWAS of C-reactive protein (CRP) in the UK Biobank serving as a positive control outcome.ResultsGenetically predicted UC is causally associated with decreased levels of albumin (ALB) and liver iron content, while genetically predicted CD is causally associated with increased levels of alkaline phosphatase (ALP). Moreover, genetically predicted UC or CD increases the risk of PSC, and CD increases the risk of PBC. Neither UC nor CD causally increases the risk of cholelithiasis and NAFLD.ConclusionUC affects the levels of ALB and liver iron content, while CD affects the levels of ALP. Both UC and CD increase the risk of PSC, and CD increases the risk of PBC.
Case report: Rare benign obstructive disease of the biliary tract—a rare case of eosinophilic cholangitis
Authors: Huang Xiao-Ning , Fang Qi-Min , Zhong Yu-Feng , Liu Jing 
Published: January 2024

ObjectiveEosinophilic cholangitis (EC) is an uncommon form of benign biliary obstruction. It frequently eludes accurate clinical diagnosis, leading to inappropriate treatment methods. It is our aspiration that this clinical report will impart comprehensive insights into EC and, specifically, the critical role of tomographic examination.Case summaryA 34-year-old man was urgently admitted to the hospital due to excruciating abdominal distress persisting for several hours. Following a six-day course of anti-inflammatory therapy, his symptoms displayed marginal improvement, prompting his discharge. He returned to the hospital a month later for re-examination on doctor’s orders. Based on the results of the re-examination, the patient refused steroid hormone shock therapy and subsequently underwent laparoscopic left-lateral hepatic lobectomy in order to confirm the diagnosis. The preoperative absolute counts of eosinophils in the peripheral blood were documented as 2.3 × 109/L, 3.06 × 109/L, and 1.50 × 109/L consecutively; concurrently, the corresponding percentages of eosinophils were quantified at levels of 21.90%, 30.70%, and 19.20%. The subsequent postoperative pathological assessment unveiled EC as the definitive diagnosis. The patient has since remained free from disease recurrence and is presently alive.ConclusionWhen encountering a patient presenting with persistent elevation in absolute eosinophil count in peripheral blood, coupled with imaging manifestations suggestive of intrahepatic periductal inflammation, diagnosis of EC should be highly suspected. The most optimal diagnostic and therapeutic workflow for EC could entail CT-guided liver lesion biopsy, ensued by glucocorticoid pulse therapy, and finally, short-term monitoring utilizing CT or MRI (including T1WI, T2WI, DWI, CEMRI) techniques.
A sequence-based machine learning model for predicting antigenic distance for H3N2 influenza virus
Authors: Li Xingyi , Li Yanyan , Shang Xuequn , Kong Huihui 
Published: January 2024

IntroductionSeasonal influenza A H3N2 viruses are constantly changing, reducing the effectiveness of existing vaccines. As a result, the World Health Organization (WHO) needs to frequently update the vaccine strains to match the antigenicity of emerged H3N2 variants. Traditional assessments of antigenicity rely on serological methods, which are both labor-intensive and time-consuming. Although numerous computational models aim to simplify antigenicity determination, they either lack a robust quantitative linkage between antigenicity and viral sequences or focus restrictively on selected features.MethodsHere, we propose a novel computational method to predict antigenic distances using multiple features, including not only viral sequence attributes but also integrating four distinct categories of features that significantly affect viral antigenicity in sequences.ResultsThis method exhibits low error in virus antigenicity prediction and achieves superior accuracy in discerning antigenic drift. Utilizing this method, we investigated the evolution process of the H3N2 influenza viruses and identified a total of 21 major antigenic clusters from 1968 to 2022.DiscussionInterestingly, our predicted antigenic map aligns closely with the antigenic map generated with serological data. Thus, our method is a promising tool for detecting antigenic variants and guiding the selection of vaccine candidates.
Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury
Authors: Rincon Sabatino Samantha , Sangaletti Rachele , Griswold Anthony , Dietrich W. Dalton , King Curtis S. , Rajguru Suhrud M. 
Published: January 2024

IntroductionPrevention or treatment for acoustic injury has been met with many translational challenges, resulting in the absence of FDA-approved interventions. Localized hypothermia following noise exposure mitigates acute cochlear injury and may serve as a potential avenue for therapeutic approaches. However, the mechanisms by which hypothermia results in therapeutic improvements are poorly understood.MethodsThis study performs the transcriptomic analysis of cochleae from juvenile rats that experienced noise-induced hearing loss (NIHL) followed by hypothermia or control normothermia treatment.ResultsDifferential gene expression results from RNA sequencing at 24 h post-exposure to noise suggest that NIHL alone results in increased inflammatory and immune defense responses, involving complement activation and cytokine-mediated signaling. Hypothermia treatment post-noise, in turn, may mitigate the acute inflammatory response.DiscussionThis study provides a framework for future research to optimize hypothermic intervention for ameliorating hearing loss and suggests additional pathways that could be targeted for NIHL therapeutic intervention.
Association of dietary fat intake with skeletal muscle mass and muscle strength in adults aged 20–59: NHANES 2011–2014
Authors: Wang Shijia , Zhang Yu , Zhang Dandan , Wang Fang , Wei Wei , Wang Qiong , Bao Yuanyuan , Yu Kang 
Published: January 2024

BackgroundSarcopenia, a progressive loss of skeletal muscle mass and strength, needs to initially prevent in the twenties. Meanwhile, there is a lack of research on the effects of fat consumption on skeletal muscle mass and strength in adults aged 20–59. We aimed to assess associations between dietary fat intake and skeletal muscle mass, as measured by appendicular lean mass adjusted for body mass index (ALMBMI), and muscle strength, as represented by handgrip strength adjusted for body mass index (GSMAXBMI), among adults aged 20–59.MethodsDietary fat intake per kilogram of actual body weight was assessed using two 24h recalls, while ALM and GSMAX were measured using DXA and a handgrip dynamometer, respectively. A weighted multiple linear regression model was employed to analyze the association between dietary fat intake and skeletal muscle mass, utilizing data from the National Health and Nutrition Examination Survey spanning from 2011 to 2014. To assess the non-linear relationship and saturation value between dietary fat intake and skeletal muscle mass, a smooth curve fitting approach and a saturation effect analysis model were utilized.ResultsThe study comprised a total of 5356 subjects. After adjusting for confounding factors, there was a positive association observed between dietary fat intake and ALMBMI as well as GSMAXBMI. The relationship between dietary fat intake and ALMBMI showed an inverted U-shaped curve, as did the association with GSMAXBMI. Turning points were observed at 1.88 g/kg/d for total fat intake and ALMBMI, as well as at 1.64 g/kg/d for total fat intake and GSMAXBMI. Furthermore, turning points were still evident when stratifying by gender, age, protein intake, and physical activity. The turning points were lower in individuals with low protein intake(&lt;0.8 g/kg/d) and high levels of physical activity.ConclusionThe moderate dietary fat intake can be beneficial for muscle mass and strength in adults aged 20–59 under specific conditions. Special attention should be directed toward the consumption of fats in individuals with low protein intake and those engaged in high levels of physical activity.
Efficacy and safety analysis of TACE + PEI + lenvatinib compared with TACE + lenvatinib for the treatment of hepatocellular carcinoma with PVTT: a retrospective study
Authors: Lu Haohao , Zheng Chuansheng , Liang Bin , Xia Xiangwen , Fan Hongjie 
Published: January 2024

ObjectiveThe aim of this study was to investigate the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) and lenvatinib in HCC patients with PVTT (Vp2-3), thus providing a safe and effective treatment strategy for advanced HCC patients.Materials and methodsClinical data of 227 patients with unresectable HCC and PVTT treated at the Union Hospital from January 2018 to December 2021 were retrospectively analyzed. The patients were divided into two groups according to their treatment methods: TACE+PEI+lenvatinib group (N=103) and TACE+lenvatinib group (N=124).ResultsThe proportion of patients with disappearance, shrinkage, or no change of PVTT after treatment was significantly higher in the TACE+PEI+lenvatinib group compared to the TACE+lenvatinib group, with statistical significance (P&lt;0.001). The TACE+PEI+lenvatinib group had higher objective response rate (ORR) (50.5% vs. 25.8%, P&lt;0.001) and disease control rate (DCR) (87.4% vs. 74.2%, P=0.013) than the TACE+lenvatinib group. The median progression-free survival (mPFS) of the TACE+PEI+lenvatinib group was longer than that of the TACE+lenvatinib group (8.1 months vs. 6.5 months, P&lt;0.001). Consistently, the median overall survival (mOS) of the TACE+PEI+lenvatinib group was longer than that of the TACE+lenvatinib group (17.1 months vs. 13.9 months, P&lt;0.001).ConclusionAmong HCC patients with PVTT (Vp2-3), TACE+PEI+lenvatinib is more effective comparing to TACE+lenvatinib in prolonging PFS and OS. The control of PVTT in the TACE+PEI+lenvatinib group was significantly more satisfactory than that in the TACE+lenvatinib group. TACE+PEI+lenvatinib is a safe and effective treatment strategy for HCC patients with PVTT (Vp2-3).
Trends in waking salivary alpha-amylase levels following healing lucid dreams
Authors: Yount Garret , Taddeo Sitara , Stumbrys Tadas , Kriegsman Michael , Wahbeh Helané 
Published: January 2024

IntroductionSalivary alpha-amylase (sAA) is considered a marker of autonomic nervous system activity in stress research, and atypical waking sAA responses have been reported for traumatized individuals. Lucid dreams, characterized by a dreamer’s awareness of their dream state while remaining asleep, have shown promising preliminary evidence of their potential to enhance mental health. This study’s objective was to evaluate sAA in relation to healing lucid dreams.MethodsParticipants experiencing PTSD symptoms attended a six-day workshop delivered via live video designed to teach techniques for transforming trauma through dreamwork and dream lucidity. Participants (n = 20) collected saliva samples each morning, immediately upon awakening (Time 1) and 30 min afterward (Time 2). sAA levels were determined by enzymatic assay, and the waking sAA slope was calculated as the difference of Time 2 minus Time 1. Participants completed dream reports each morning, with a dream classified as a ‘healing lucid dream’ when they reported attaining lucidity and remembered their intention to manifest a healing experience within the dreamscape.ResultsOf eight participants experiencing healing lucid dreams, four were able to provide usable saliva samples. Statistical tests on these four participants were not significant because of low power. However, nonsignificant positive associations were observed between experiencing more healing lucid dreams and increased waking sAA slope.ConclusionThe results did not reveal a consistent effect of healing lucid dreams on waking sAA slope. Identifying meaningful patterns in this relationship will require larger samples and more stringent control over saliva collection procedures in future studies.