bluuebunny/crossref_metadata_2025_split huggingface dataset:
Little evidence for color- or size-based mating preferences by male strawberry poison frogs (Oophaga pumilio)
Authors: Lehman Mik R. , González-Santoro Marco , Richards-Zawacki Corinne L. 
Published: February 2024

Abstract
While there are many studies documenting female mating preferences across taxa, male mate choice remains relatively understudied. Male mate choice often develops when there is variation in female quality and thus the fitness benefits of mating with particular females. Specifically, males tend to prefer females with traits that confer direct fitness benefits such as large body size, which may be linked with high fecundity. Prior work has shown that females of the strawberry poison frog, Oophaga pumilio, prefer males bearing certain coloration (most often the female’s own color), and that this preference can be learned through maternal imprinting. Females have been shown to prefer larger males as well. Here we test whether similar mate preferences for color and size exist in males of this species using two-way choice tests on captive bred male O. pumilio. In each test focal males were placed in an arena with two stimulus females: either both of the same size but differing in color, or both of the same color but differing in size. We found only weak evidence for behavioral biases toward particular colors and no evidence for biases toward larger females, suggesting that males of O. pumilio do not predictably choose mates based on these female traits. Despite several aspects of their natural history that suggest males have reasons to be choosy, our findings suggest that the cost of mate rejection may outweigh any fitness benefits derived from being selective of mates. Studies of additional populations, ideally conducted on wild individuals, are needed to better understand the range of conditions under which males may exhibit mate choice and the types of traits on which they base these choices.

Significance statement
To fully understand the fitness landscapes and evolutionary trajectories that result from sexual selection, we need to understand when and how the mate preferences of the two sexes act and interact. While female mate choice has been widely studied, male mate choice remains poorly understood. To help bridge this gap, we studied male mate preferences in the strawberry poison frog Oophaga pumilio, a small brightly colored frog for which female preferences for male color and size have been well-documented. We found no evidence that male O. pumilio exhibit mate preferences based on female size and little evidence for male mate preferences based on female color. This is surprising given that larger females are often more fecund, male O. pumilio are known to exhibit color-based behavioral biases in the context of male-male competition, and both sexes provide parental care.
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Authors: Krumm Laura , Pozner Tatyana , Zagha Naime , Coras Roland , Arnold Philipp , Tsaktanis Thanos , Scherpelz Kathryn , Davis Marie Y. , Kaindl Johanna , Stolzer Iris , Süß Patrick , Khundadze Mukhran , Hübner Christian A. , Riemenschneider Markus J. , Baets Jonathan , Günther Claudia , Jayadev Suman , Rothhammer Veit , Krach Florian , Winkler Jürgen , Winner Beate , Regensburger Martin 
Published: February 2024

AbstractBiallelic loss of SPG11 function constitutes the most frequent cause of complicated autosomal recessive hereditary spastic paraplegia (HSP) with thin corpus callosum, resulting in progressive multisystem neurodegeneration. While the impact of neuroinflammation is an emerging and potentially treatable aspect in neurodegenerative diseases and leukodystrophies, the role of immune cells in SPG11–HSP patients is unknown. Here, we performed a comprehensive immunological characterization of SPG11–HSP, including examination of three human postmortem brain donations, immunophenotyping of patients’ peripheral blood cells and patient-specific induced pluripotent stem cell-derived microglia-like cells (iMGL). We delineate a previously unknown role of innate immunity in SPG11–HSP. Neuropathological analysis of SPG11–HSP patient brain tissue revealed profound microgliosis in areas of neurodegeneration, downregulation of homeostatic microglial markers and cell-intrinsic accumulation of lipids and lipofuscin in IBA1+ cells. In a larger cohort of SPG11–HSP patients, the ratio of peripheral classical and intermediate monocytes was increased, along with increased serum levels of IL-6 that correlated with disease severity. Stimulation of patient-specific iMGLs with IFNγ led to increased phagocytic activity compared to control iMGL as well as increased upregulation and release of proinflammatory cytokines and chemokines, such as CXCL10. On a molecular basis, we identified increased STAT1 phosphorylation as mechanism connecting IFNγ-mediated immune hyperactivation and SPG11 loss of function. STAT1 expression was increased both in human postmortem brain tissue and in an Spg11–/– mouse model. Application of an STAT1 inhibitor decreased CXCL10 production in SPG11 iMGL and rescued their toxic effect on SPG11 neurons. Our data establish neuroinflammation as a novel disease mechanism in SPG11–HSP patients and constitute the first description of myeloid cell/ microglia activation in human SPG11–HSP. IFNγ/ STAT1-mediated neurotoxic effects of hyperreactive microglia upon SPG11 loss of function indicate that immunomodulation strategies may slow down disease progression.
Partitioning of highly siderophile elements between monosulfide solid solution and sulfide melt at high pressures
Authors: Fonseca Raúl O. C. , Beyer Christopher , Bissbort Thilo , Hartmann Rebecca , Schuth Stephan 
Published: February 2024

AbstractBase metal sulfides (Fe–Ni–Cu–S) are ubiquitous phases in mantle and subduction-related lithologies. Sulfides in the mantle often melt incongruently, which leads to the production of a Cu–Ni-rich sulfide melt and a solid residue called monosulfide solid solution (mss). Even though peridotite-hosted sulfides, which tend to be more Ni-rich, are likely completely molten at mantle potential temperatures, the same is not true for eclogite-hosted Ni-poor, Fe-rich sulfides. Because of this, solid crystalline mss may persist at higher pressures and equilibrate with co-existing sulfide melt along colder geotherms, like those associated with subduction zones. Because highly siderophile elements (HSE—Pt, Pd, Rh, Ru, Os, Ir, and Re) are known to fractionate as a result of mss/sulfide-melt equilibrium, the persistence of an mss/sulfide-melt assemblage to higher pressures may lead to the fractionation of these elements during the subduction process. In this contribution, we carried out an experimental investigation of the partitioning behavior of the HSE, as well as Cu and Ni, between mss and sulfide melt over a pressure and temperature range relevant to equilibration between Earth’s surface and transition zone depths (0.1 MPa to 14 GPa; 930–1530 $$^{\circ }$$

∘

C), and variable Ni contents in sulfide. Results show that at higher pressures, the HSE are considerably less fractionated as a result of mss and sulfide melt equilibrium compared to lower pressure conditions. This is exemplified by a lowering of the $$D_{i}^\mathrm{mss/melt}$$

D

i

mss
/
melt

for the more compatible HSE (Ru, Os, Ir, Rh and Re) from around 10 at 0.1 MPa to just above or below unity at 14 GPa. Moreover, the higher the Ni content of the bulk sulfide assemblage, the larger the degree of change in the magnitude of HSE fractionation seen over the pressure range studied. The exchange coefficient ($$K_D^{\textrm{Ru}-\textrm{Pt}}$$

K
D

Ru
-
Pt

) between highly compatible HSE (Ru) and less compatible Pt illustrates a notable contrast. In the Ni-poor composition (E1), $$K_D^{\textrm{Ru}-\textrm{Pt}}$$

K
D

Ru
-
Pt

changes from 27 at 0.1 MPa to 6 at 14 GPa. In contrast, the Ni-rich composition exhibits a broader range, with $$K_D^{\textrm{Ru}-\textrm{Pt}}$$

K
D

Ru
-
Pt

ranging from 150 to 17 across the same pressure interval. Our results highlight key differences between experimental data obtained at lower and higher pressure, and how composition, namely the Ni content of sulfide, affects HSE partitioning behavior.
The effectiveness of E-health interventions promoting physical activity in cancer survivors: a systematic review and meta-analysis of randomized controlled trials
Authors: Xiao Kangjiao , Tang Li , Chen Yingtong , Zhou Jiahui , Yang Qiaolan , Wang Rui 
Published: February 2024

Abstract
Purpose
This systematic review and meta-analysis aimed to identify whether E-health interventions effectively improve physical activity (PA) in cancer survivors.

Methods
PubMed, Web of Science, and Cochrane Library databases were searched from inception to October 21, 2023. Randomized controlled trials reporting the effect of E-health interventions on PA among cancer survivors were included. Random-effect models were used to calculate standardized mean differences (SMD) and the 95% confidence interval (CI).

Results
In total, 15 trials with 2,291 cancer survivors were included in this meta-analysis. The results showed that E-health interventions improved moderate to vigorous physical activity (MVPA) among cancer survivors (SMD = 0.26, 95% CI 0.08, 0.43, N = 8, p < 0.001, I2 = 37%), as well as moderate physical activity (MPA) (SMD = 0.22, 95% CI 0.05, 0.38, N = 9, p < 0.001, I2 = 28%) and vigorous physical activity (VPA) (SMD = 0.34, 95% CI 0.15, 0.54, N = 6, p < 0.001, I2 = 11%).

Conclusion
E-health interventions are effective at promoting PA among cancer survivors. As current research primarily focuses on immediate post-intervention measurements with limited follow-up data, further investigation is required to explore the long-term effects of E-health interventions on PA.
A subregion-based RadioFusionOmics model discriminates between grade 4 astrocytoma and glioblastoma on multisequence MRI
Authors: Wei Ruili , Lu Songlin , Lai Shengsheng , Liang Fangrong , Zhang Wanli , Jiang Xinqing , Zhen Xin , Yang Ruimeng 
Published: February 2024

Abstract
Purpose
To explore a subregion-based RadioFusionOmics (RFO) model for discrimination between adult-type grade 4 astrocytoma and glioblastoma according to the 2021 WHO CNS5 classification.

Methods
329 patients (40 grade 4 astrocytomas and 289 glioblastomas) with histologic diagnosis was retrospectively collected from our local institution and The Cancer Imaging Archive (TCIA). The volumes of interests (VOIs) were obtained from four multiparametric MRI sequences (T1WI, T1WI + C, T2WI, T2-FLAIR) using (1) manual segmentation of the non-enhanced tumor (nET), enhanced tumor (ET), and peritumoral edema (pTE), and (2) K-means clustering of four habitats (H1: high T1WI + C, high T2-FLAIR; (2) H2: high T1WI + C, low T2-FLAIR; (3) H3: low T1WI + C, high T2-FLAIR; and (4) H4: low T1WI + C, low T2-FLAIR). The optimal VOI and best MRI sequence combination were determined. The performance of the RFO model was evaluated using the area under the precision-recall curve (AUPRC) and the best signatures were identified.

Results
The two best VOIs were manual VOI3 (putative peritumoral edema) and clustering H34 (low T1WI + C, high T2-FLAIR (H3) combined with low T1WI + C and low T2-FLAIR (H4)). Features fused from four MRI sequences ($${F}_{seq}^{\mathrm{1,2},\mathrm{3,4}}$$

F

seq

1
,
2

,

3
,
4

) outperformed those from either a single sequence or other sequence combinations. The RFO model that was trained using fused features $${F}_{seq}^{\mathrm{1,2},\mathrm{3,4}}$$

F

seq

1
,
2

,

3
,
4

achieved the AUPRC of 0.972 (VOI3) and 0.976 (H34) in the primary cohort (p = 0.905), and 0.971 (VOI3) and 0.974 (H34) in the testing cohort (p = 0.402).

Conclusion
The performance of subregions defined by clustering was comparable to that of subregions that were manually defined. Fusion of features from the edematous subregions of multiple MRI sequences by the RFO model resulted in differentiation between grade 4 astrocytoma and glioblastoma.
Structure of putative epidermal sensory receptors in an acoel flatworm, Praesagittifera naikaiensis
Authors: Sakagami Tosuke , Watanabe Kaho , Hamada Mayuko , Sakamoto Tatsuya , Hatabu Toshimitsu , Ando Motonori 
Published: February 2024

AbstractAcoel flatworms possess epidermal sensory-receptor cells on their body surfaces and exhibit behavioral repertoires such as geotaxis and phototaxis. Acoel epidermal sensory receptors should be mechanical and/or chemical receptors; however, the mechanisms of their sensory reception have not been elucidated. We examined the three-dimensional relationship between epidermal sensory receptors and their innervation in an acoel flatworm, Praesagittifera naikaiensis. The distribution of the sensory receptors was different between the ventral and dorsal sides of worms. The nervous system was mainly composed of a peripheral nerve net, an anterior brain, and three pairs of longitudinal nerve cords. The nerve net was located closer to the body surface than the brain and the nerve cords. The sensory receptors have neural connections with the nerve net in the entire body of worms. We identified five homologs of polycystic kidney disease (PKD): PKD1-1, PKD1-2, PKD1-3, PKD1-4, and, PKD2, from the P. naikaiensis genome. All of these PKD genes were implied to be expressed in the epidermal sensory receptors of P. naikaiensis. PKD1-1 and PKD2 were dispersed across the entire body of worms. PKD1-2, PKD1-3, and PKD1-4 were expressed in the anterior region of worms. PKD1-4 was also expressed around the mouth opening. Our results indicated that P. naikaiensis possessed several types of epidermal sensory receptors to convert various environmental stimuli into electrical signals via the PKD channels and transmit the signals to afferent nerve and/or effector cells.
Robot-assisted surgery in thoracic and visceral indications: an updated systematic review
Authors: Grössmann-Waniek Nicole , Riegelnegg Michaela , Gassner Lucia , Wild Claudia 
Published: February 2024

Abstract
Background
In surgical advancements, robot-assisted surgery (RAS) holds several promises like shorter hospital stays, reduced complications, and improved technical capabilities over standard care. Despite extensive evidence, the actual patient benefits of RAS remain unclear. Thus, our systematic review aimed to assess the effectiveness and safety of RAS in visceral and thoracic surgery compared to laparoscopic or open surgery.

Methods
We performed a systematic literature search in two databases (Medline via Ovid and The Cochrane Library) in April 2023. The search was restricted to 14 predefined thoracic and visceral procedures and randomized controlled trials (RCTs). Synthesis of data on critical outcomes followed the Grading of Recommendations, Assessment, Development, and Evaluation methodology, and the risk of bias was evaluated using the Cochrane Collaboration’s Tool Version 1.

Results
For five out of 14 procedures, no evidence could be identified. A total of 20 RCTs and five follow-up publications met the inclusion criteria. Overall, most studies had either not reported or measured patient-relevant endpoints. The majority of outcomes showed comparable results between study groups. However, RAS demonstrated potential advantages in specific endpoints (e.g., blood loss), yet these findings relied on a limited number of low-quality studies. Statistically significant RAS benefits were also noted in some outcomes for certain indications—recurrence, quality of life, transfusions, and hospitalisation. Safety outcomes were improved for patients undergoing robot-assisted gastrectomy, as well as rectal and liver resection. Regarding operation time, results were contradicting.

Conclusion
In summary, conclusive assertions on RAS superiority are impeded by inconsistent and insufficient low-quality evidence across various outcomes and procedures. While RAS may offer potential advantages in some surgical areas, healthcare decisions should also take into account the limited quality of evidence, financial implications, and environmental factors. Furthermore, considerations should extend to the ergonomic aspects for maintaining a healthy surgical environment.

Graphical abstract
RSV-Prophylaxe
Authors: Resch Bernhard , Sever-Yildiz Gülsen 
Published: February 2024

ZusammenfassungHändedesinfektion und Mund-Nasen-Schutz sind hocheffektive Prophylaxemaßnahmen, wie die COVID-19-Pandemie gezeigt hat. Nach 25 Jahren medikamentöser Prophylaxe mit dem monoklonalen Antikörper Palivizumab und zahlreichen Schwierigkeiten in der Umsetzung bei Risikokindern (Compliance, saisonale Problematik, monatliche i.m.-Gaben, hohe Kosten, Schwierigkeiten mit der chefärztlichen Bewilligung) gibt es nun erfreuliche Neuentwicklungen. Ein neuer monoklonaler Antikörper mit langer Halbwertszeit (deckt 5 Monate ab) – Nirsevimab – bietet nun erstmals die Chance für alle Kinder, wie ein Impfstoff zur Verfügung zu stehen und die Erkrankung in das 2. Lebensjahr zu verschieben, wo deutlich weniger schwere Verläufe zu erwarten wären. Mit Abrysvo gibt es nun auch einen Impfstoff, der den Schwangeren im letzten Trimenon verabreicht werden kann und über die nachfolgenden Monate durch den passiven maternalen Antikörpertransfer einen respektablen Schutz in den ersten kindlichen Lebensmonaten bietet. Je nach Geburtsmonat stellen sich nun verschiedene Prophylaxemöglichkeiten (Nirsevimab alleine oder in Kombination mit Abrysvo oder am Ender der Saison Abrysvo alleine etc.) dar, die Kinder vor einer frühen und schweren RSV-Infektion zu schützen.
ARGo: augmented reality-based mobile Go stone collision game
Authors: Lee Dohui , Won Sohyun , Kim Jiwon , Kwon Hyuk-Yoon 
Published: February 2024

AbstractIn this study, we present a mobile Go stone collision game based on augmented reality, which we call ARGo, inspired by the traditional Korean board game, Alkkagi. ARGo aims to resolve two main issues: (1) the portability and space constraints of the original Alkkagi and (2) the limited sense of reality due to the touchscreen-based interface of the existing mobile Alkkagi games. To improve a sense of the reality of the game, ARGo provides a gameplay interface similar to the original Alkkagi by recognizing the user‘s hand motion based on AR. Additionally, it provides a customization mechanism for each user to improve the recognition of the hand motion and the strength of the attack considering each user‘s characteristics. Finally, we make the following three main contributions. First, we employ the automata theory to design the game and collision scenarios between stones. Consequently, we can clearly define the complicated states incurred by AR-based motion recognition and collisions between virtual objects. Second, we propose a collision equation based on Continuous Collision Detection tailored to ARGo, i.e., Go stones and their collisions. Through experimental studies, we demonstrate that the collision equation enables the simulation of the exact collision effects. Third, through user experience studies, we verify the effectiveness of ARGo by showing the effects of the functions implemented in ARGo and its superiority over the existing mobile game Alkkagi Mania.
Internalism and Culpable Irrationality
Authors: Bergman Karl Gustav 
Published: February 2024

AbstractAccording to internalism about rationality, the ir/rationality of a subject depends only on how things appear from her subjective perspective. According to culpabilism, rationality is a normative standard such that violations of rationality are (at least sometimes) blameworthy. According to a classical line of reasoning, culpabilism entails internalism. I argue that, to the contrary, culpabilism entails that internalism is false. The internalist cannot accommodate the possibility of culpable irrationality.
Characterization and evaluation of the morphological attributes of Ethiopian mustard (Brassica carinata A. Braun) landraces
Authors: Hagos Abraha Rahiel , Shaibu Abdulwahab S. , Liang Jianli , Wu Jian , Lin Runmao , Wang Xiaowu 
Published: February 2024

AbstractEthiopian mustard (Brassica carinata A. Braun) is one of the Brassica leafy vegetables and oilseed crops, which can withstand adverse environmental conditions. This study was conducted to characterize and evaluate the leaf attributes of 313 Ethiopian mustard accessions grown in the greenhouse and field in 2018/19 in Beijing, China. Data on 18 different leaf morphological attributes were collected based on the IBPGR for Brassica and Raphanus descriptor format and Fiji Image J. The collected data were subjected to descriptive statistics using JMP version 14 software. Results indicate that the majority of the accessions had serrated leaf margin, intermediate juvenile development, rounded apex leaf shape, absence of leaf pubescence, number of lobes > 5 and had intermediate number of leaves per plant with frequencies of 101, 213, 223, 244, 183 and 289, respectively. The accessions had also white midrib color, light green leaf color, purple petiole color, purple stem color and purple apex leaf color pigments with frequencies of 168, 165, 104, 113 and 122, respectively. Significant differences were observed among the accessions for leaf size attributes (p < 0.001) indicating their potential as leafy vegetables. Furthermore, there were significant accession × environment effects for the laminal length, total leaf length, leaf area, leaf weight and petiole length. Notably, 71% of the accessions had an average of 81 days flowering time. The multivariate cluster and principal component analyses divided the 313 accessions into eight groups with distinctive information; consisting of 81, 37, 79, 38, 14, 11, 6 and 47 accessions. Thus, this study provides important information about Ethiopian mustard germplasms that is vital for further advancement and genetic improvement of the crop.
Study on the effects of pollen sources on the agronomic, biochemical, mineral, and pomological traits of date palm (Phoenix dactylifera L.) cv 'Deglet Nour' fruits in Degache Oases (Tunisia)
Authors: Kadri Karim , Jemni Monia , Mesnoua Mohammed , Sharma Shyam Sundar , Malik Anoop Anand , Makhlouf Souhayla , Elsafy Mohammed 
Published: February 2024

AbstractGiven the dioecious nature of date palms, selecting an effective pollinizer bearing a substantial quantity of high-quality pollen is imperative. In this study, we investigated the effects of 11 male date palm cultivars from Tunisia on the production of female trees, fruit sets, and the characteristics of 'Deglet Nour' cultivar dates. The comparison of pollen germination rates showed that ABD1 and P169 pollens exhibited outstanding viability, with 98.7% and 98.3%, respectively. On the other hand, P169 pollen had the highest germination rate, at 86.3%. The most remarkable fruit set (90.7%) and retention rate (69.7%) were observed in response to P13 pollen. In response to the P165 pollinator, the fruit stood out among the resulting fruits for their notable weight, averaging 11.6 g. In addition, pollination with P90 increased total soluble solids (measured at 74.4°Brix in the Tamr stage), whereas P7-pollinated fruits recorded the highest levels of reducing sugars, reaching 41%. Notably, the highest acidity levels were found in P7-pollinated fruits (0.29%), and pollen sources significantly influenced the fruits' mineral content.Moreover, regarding pomological characteristics, fruits pollinated with P4 attained maximum size, measuring 4.10 cm. Conversely, P7-pollinated fruits had a notable width of 2.02 cm. These findings illustrate the possibility of the selective application of high-value pollinizers and emphasize the direct influence of pollen sources on fruit quantity and quality.