bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amplified Production of a DNA Decoy Catalyzed by Intracellular MicroRNA
Authors: Yasuda Soshu , Morihiro Kunihiko , Koga Shuichiro , Okamoto Akimitsu 
Published: February 2025

AbstractDNA decoys inhibit cellular transcription factors and are expected to be among the nucleic acid drugs used to downregulate the transcription process. However, spatially controlling the on/off efficacy of DNA decoys to avoid side effects on normal cells is challenging. To reduce undesired decoy function in normal cells, we adopted catalytic hairpin assembly (CHA) to produce a DNA duplex from a hairpin DNA pair in response to a specific microRNA (miRNA). We designed the DNA hairpin pairs to form a DNA decoy that binds to nuclear factor kappa B (NF‐κB), whose overexpression is related to many diseases, including cancer. The transformation of the DNA hairpin pair to the NF‐κB DNA decoy was catalyzed by miR‐21, which is expressed in various types of cancers. Intracellular CHA progression and the inhibitory effect against NF‐κB were observed only in miR‐21 overexpressing cancer cells. The intracellular miR‐21‐catalyzed production of the NF‐κB DNA decoy has the potential to reduce side effects on normal cells, thereby strengthening the therapeutic profile of the CHA‐decoy system. The ability to customize the combination of catalytic miRNA and target transcription factors would allow our technology to serve as a “personalized drug discovery system” for a variety of challenging diseases, including cancer.
Identical Grain Atomic Force Microscopy Elucidates Facet‐Dependent Restructuring of Copper for CO2 Electroreduction
Authors: Wang Hui , Mandemaker Laurens D. B. , de Ruiter Jim , Yu Xiang , van der Stam Ward , Weckhuysen Bert M. 
Published: February 2025

AbstractStudies on the catalyst restructuring during the electrochemical CO2 reduction reaction (eCO2RR) are limited and mostly focused on Cu (001) or (111) single crystals as model systems. A comprehensive overview of the dynamic restructuring of different Cu facets is lacking. Here, we first reveal the facet‐dependent restructuring of polycrystalline Cu electrodes through electron backscatter diffraction (EBSD) and identical grain atomic force microscopy (AFM). This combined analysis provides new insights into the evolution of crystal domains (EBSD) and surface topography (AFM) at varying conditions (e.g., applied potential and oxidative‐reductive pulses). The statistic slope distribution function was applied to study the restructuring asymmetry on five Cu facets (i.e., planar vs. atom stepped). We find that planar Cu (001) shows a square‐shaped morphology after eCO2RR with 4‐fold asymmetry restructuring behavior, while triangular features dominate on Cu (111), evidenced by surface changes with 3‐fold asymmetry. 2‐fold restructuring is observed for Cu (114), (212), and (124) with atom steps, resulting in forming elongated structures. Therefore, the surface restructuring is dominated by the asymmetry of its facet lattice structure (i.e., planar vs. atom‐stepped). This work underscores the potential of combining techniques to elucidate the relationship between surface restructuring and crystal facets on different length scales.
Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic‐Gated Molecular Imaging
Authors: Tu Tingting , Huan Shuangyan , Feng Xueyan , Ke Guoliang , Li Lele , Zhang Xiao‐Bing 
Published: February 2025

AbstractDespite intense interest in design of DNAzyme sensors for molecular detection and imaging in living cells, their intracellular applications are still hampered by limited spatial control and poor bio‐stability. Here we present controlled spatial confinement of a rationally designed, microRNA (miRNA)‐activatable DNAzyme sensor probe (mDz) within the cavity of DNA nanocage, enabling efficient intracellular delivery with improved bio‐stability for AND‐gate molecular imaging. The mDz that possesses inactive DNAzyme activity is designed by the introduction of a blocking DNA strand, while miR‐21 mediated strand displacement reaction allows for the formation of an intact DNAzyme structure for metal‐ion‐mediated catalytic reaction. Furthermore, the DNA nanocage serves as a nanocarrier for intracellular delivery of mDz, in which the cavity is accessible to the dual targets for logic‐gated molecular imaging, while the confinement effect can provide steric protection of mDz by obstructing nuclease from entering the cavity of the DNA nanocage, resulting in enhanced bio‐stability and improved molecular imaging precision. This strategy paves a way for the engineering of activatable DNA nanosensors with both self‐delivery and self‐protection capabilities to detect diverse intracellular targets.
Triplet Exciplex Mediated Multi‐Color Ultra‐Long Afterglow Mate‐rials
Authors: Ma Liangwei , Liu Yiwei , Jin Xin , Jiang Tao , Zhou Lei , Wang Qiaochun , Tian He , Ma Xiang 
Published: February 2025

AbstractOrganic long‐lived phosphorescent materials demonstrating ultra‐long photoluminescence have practical advantages owing to their flexible design and easy processability. However, the exact photophysical process underpinning the persistent‐luminescent continues to elude full understanding, and the principles governing the compatibility of hosts and guests remain elusive. In this work, a new type of nonradiative energy transfer mechanism is proposed for the bi‐component RTP system. Different from Förster resonance energy transfer or Dexter‐type energy transfer, this energy transfer mechanism primarily relies on a triplet exciplex to exchange the electron. This facilitates the formation of triplet excitons that are otherwise difficult to excite directly. An evaluation methodology is devised to gauge the potential of a specific dopant‐host combination toward generating pronounced afterglow. According to this framework, the enhancement of the afterglow is proportional to the decrease in the activation energy (ΔG≠) associated with the electron transfer reaction between the dopant and the host. Notably, when the ΔG≠ too larger, no observable afterglow occurs, as higher ΔG≠ values significantly impede the electron transfer reaction between the two components. Furthermore, the remarkable dependence of afterglow intensity on the dopant concentration renders the bi‐component RTP system highly promising for applications requiring ultra‐high sensitivity and broad‐spectrum detection capabilities.
Advancing Breath Biomarker Detection with Chemiresistive Metal Oxide Nanostructures: A Pathway to Next‐Generation Diagnostic Tools
Authors: Amu‐Darko Jesse Nii Okai 
Published: February 2025

AbstractBreath biomarker detection represents a transformative frontier in non‐invasive diagnostics, offering rapid, real‐time insights into health conditions ranging from metabolic disorders to cancer. Metal oxide nanostructures (MONs) have emerged as key materials in this research because of their large surface area, adjustable electrical characteristics, and sensitivity to gaseous biomarkers at trace quantities. This paper examines current advances in chemiresistive MON‐based sensors, focusing on the importance of structural optimization, hybrid material systems, and functionalization strategies in improving performance. Exploring the study of complicated datasets, the prediction of biomarker signatures, and dynamic aims in tuning the quality of the sensors. Functionalization strategies also play a vital role in enhancing the performance of MON‐based sensors. By modifying the surface chemistry of chemiresistive metal oxides, researchers can tailor the sensors to preferentially adsorb certain gaseous biomarkers while minimizing interference from other compounds present in breath. Future opportunities include the development of multimodal sensors, simplified and portable devices, and durable, reusable platforms capable of long‐term operation in real‐world environments. With the confluence of nanotechnology and data‐driven analytics, MON‐based breath sensors have the potential to transform customized healthcare by providing worldwide early detection, illness monitoring, and preventative medication.
Evaluating the Drug Delivery Capacity of 3D Coordination Polymer for Anticancer Drugs
Authors: Saqlain Madiha , Muhammad Zohaib Hafiz , Ahmad Khan Maroof , Qamar Samina , Masood Sara , Lauqman Muhammad , Ilyas Mubashar , Irfan Muhammad , Li Hui 
Published: February 2025

AbstractWe synthesized {[Cd2(dTMP)2(4,4'‐azpy)2(H2O)2] ⋅ 3(O)}n a novel three‐dimensional metal nucleotide coordination polymer (CP‐1). An assessment of the CP‐1 binding affinity for anticancer drugs was conducted using molecular dynamic simulations. The virtual screening results depict that CP‐1 has a lot of potential for encapsulating the anthracycline anticancer drug doxorubicin (DOX). It hasn′t yet been investigated how to accomplish high loading capacity, efficiency, and controlled release of DOX in dTMP‐based 3D metal coordination polymers. Utilizing DOX as a drug model and our system as a drug‐loading vehicle, we used UV‐visible and circular dichroism titrations to examine the effects of its encapsulation and release. The mechanism of drug loading and release was investigated through pH‐responsive behavior by adjusting the pH value to 8, 7, 6, and 5. The results indicate the CP‐1 has a robust affinity for DOX at pH 7, which facilitates its loading on 3D porous coordination polymer. However, the maximum cumulative drug release of 87.11 % was observed at pH 5. The higher correlation coefficient (R2) was obtained at pH 5 with the Higuchi equation. It indicated that the drug released was primarily controlled with the diffusion mechanism. The CP‐1 polymer‘s ability to encapsulate DOX while also permitting a possible controlled‐release mechanism is confirmed by the combined insights from the experimental findings, energy graphs, RMSD analysis, and radius of gyration (Rg) data from MD simulations.
Natural and Magnetic Circular Dichroism from the Infrared to the UV of a Hetero[4]Helicene Radical Cation
Authors: Fusè Marco , Lupi Michela , Machalska Ewa , Mazzeo Giuseppe , Abbate Sergio , Bloino Julien , Viglianisi Caterina , Menichetti Stefano , Longhi Giovanna 
Published: February 2025

Dithiabridged triarylamine hetero[4]helicenes are an interesting class of chiral compounds characterized by a high racemization barrier which makes them an attractive material for several applications. Their rich redox chemistry allows one to obtain radical cations stable at room temperature, that can be isolated in two configurationally stable enantiomers. While several studies have been reported on systems with transition metals possessing low‐lying electronic states, the characterization of purely organic openshell systems by VCD is still scarce. This may be due to the instability of radical‐cation species and to the dark color assumed by the solution at the high concentration required by VCD. The oxidation of this molecular system shifts the first electronic transition towards the Near‐IR (NIR) region, at approximately 1250 nm. By combining ECD, VCD, MCD, NIR‐CD and computational methodologies rooted in density functional theory, we have investigated one molecule of this class of compounds and shed some light on the chiroptical properties accessible via redox‐switch.
Hydrothermal Synthesis of Single‐Crystal Europium Tungstate Hydroxide Nanobelts for Enhanced Humidity Sensing
Authors: Bao Jusheng , Yang Haiying , Xie Weicheng , Xu Kun , Zhang Ting , Li Shaojun , Chen Junming , Liu You 
Published: February 2025

AbstractHumidity sensing is crucial for environmental monitoring and industrial processes; however, existing sensors often face challenges in sensitivity and response time. This study addresses these challenges by introducing a novel material, EuWO4(OH) nanobelts, synthesized through a hydrothermal method. These nanobelts exhibit exceptional sensing performance, with a response value of 2.3×103 at 85 % RH, a rapid response time of 6.3 s, and a recovery time of 0.6 s. Unlike traditional materials, EuWO4(OH) nanobelts offer superior stability and reproducibility, making them a promising candidate for advanced humidity sensors. The distinctive electronic properties and high crystallinity of EuWO4(OH) nanobelts contribute to their high sensitivity and rapid response, which sets them apart from existing sensors. This study not only elucidates the potential of EuWO4(OH) nanobelts for humidity sensing but also provides a new direction for the development of next‐generation humidity sensors.
A study on the social integration of international secondary students in Canadian high schools
Authors: Lou Yingling 
Published: February 2025

AbstractResearch on the international secondary students (ISS) is scarce compared with the proliferating literature on their tertiary counterparts. This paper focuses on social integration experiences of ISS from diverse ethnic backgrounds, the undergirding macro‐, meso‐, and micro‐mechanisms, and the supports needed for their successful integration. It draws on a subset of data from a longitudinal qualitative study through an interdisciplinary conceptual framework. This study employs multiple case study designs with critical intercultural hermeneutics as an interpretive approach. Research methods involve (a) serial interviews with six ISS that spanned the 2022–2023 school year; (b) in‐depth interviews with their parents, homestays, teachers, and agents; (c) online observations of the students’ virtual communities; (d) documents; and (e) research journals. It uncovers three mechanisms undergirding ISS’ social integration challenges: lack of ethnic proximity, a departmentalised classroom system and capital defence. This study suggests that stakeholders and researchers of ISS must obviate deficit‐oriented and assimilationist perspectives, which attribute social integration challenges solely to ISS’ limited knowledge of mainstream culture and language. Instead, a paradigm shift is necessary to redefine the criteria for successful social integration as harmonious interaction with students from diverse ethno‐cultural backgrounds, encompassing both culturally dominant and minority groups, with educators playing a central role in fostering this integration.
Board Supervision Capability and Sustainability Report Disclosure Quality: Evidence From Small‐ and Medium‐Sized Enterprises in Taiwan's Construction Industry
Authors: Yu Hui‐Cheng 
Published: February 2025

ABSTRACTThis study explores the effect of board supervision capability on sustainability reporting quality among publicly listed small‐ and medium‐sized enterprises in Taiwan's construction industry from 2018 to 2022. Ordinal logit regression analyses are conducted. The results reveal that board supervision capability determines whether a firm will voluntarily engage in sustainability reporting strategies, which is a key factor for effectively meeting stakeholder needs. Further analysis of board supervision capability in firms of different ages indicates that the relationship between board supervision capability and sustainability reporting quality varies by firm age. This study also provides empirical evidence confirming that board supervision capability is among the key factors affecting sustainability reporting quality.
Multimodal near‐infrared molecular imaging of ex vivo endometrial carcinoma via CD47‐based targeted tracer
Authors: Lei Jing , Tian Dianfeng , Zhang Bo , Guo Hongrui , Su Huancheng , Wei Jinzheng , Li Shuai , Li Sufen , Liu Chao , Yang Xiaofeng , Zhang Sanyuan 
Published: February 2025

AbstractThe detection and complete eradication of early‐stage small tumors during hysteroscopy remains a significant clinical challenge in preserving fertility for young women with endometrial cancer (EC). The purpose of this study is to verify the feasibility of CD47 as an optical molecular imaging (OMI) target for human EC and to achieve precise localization and identification in hysteroscopic surgery. The results demonstrated that CD47 was overexpressed in EC through bioinformatics, immunohistochemistry, and qRT‐PCR. In EC cell lines, CD47‐targeted near‐infrared photoimmunotherapy (NIR‐PIT) induced cytotoxicity in a light dose‐dependent manner. Laser confocal microscopy revealed that CD47 intervention significantly increased the phagocytic effect of macrophages on EC cells. In the mice model of partial tumor resection mediated by CD47‐targeted OMI, compared to group A (immune therapy alone), group C (NIR‐PIT treatment) mice showed a reduced tumor recurrence rate after NIR‐PIT intervention. However, the difference did not reach statistical significance. We then evaluated the effect of CD47‐targeted NIR‐PIT maintenance therapy on tumor recurrence in mice. The results indicated that, compared to untreated animals, the tumor growth rate was slower in the NIR‐PIT group using CD47‐Alexa Fluor 790 (CD47‐AF790), allowing for more sustained tumor control. The freshly isolated whole uterus specimens from EC patients were co‐incubated with CD47‐AF790, and a significantly enhanced contrast of NIR visible images of tumor tissue was observed, demonstrating high sensitivity and specificity (tumor‐to‐background ratio >5.05). Finally, under fluorescence microscopy, specific fluorescent signals are observed on tumor cells. In conclusion, accurate localization and excision of EC can be accomplished by employing CD47 optical molecular contrast agents with OMI technology. This method shows potential as a viable and promising approach for the precise diagnosis of EC.
Stem cell therapies in the clinic
Authors: Acharya Shrinivas , Shaha Suyog , Bibbey Michael Griffith , Mukherji Malini , Zhao Zongmin , Mitragotri Samir 
Published: February 2025

AbstractStem cell therapies have emerged as a transformative approach in modern medicine, with the potential to address and possibly cure a broad spectrum of diseases. These therapies utilize living stem cells that can perform complex biological functions not replicable by traditional drugs. Stem cell therapies have an expanding therapeutic landscape, with several products already approved and numerous clinical trials underway. Among the various stem cell types, hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are most widely studied. In this review, we provide a detailed analysis of the current clinical landscape of stem cell therapies. We review 27 stem cell products that have received regulatory approvals and discuss 800 ongoing clinical trials, with a focus on HSCs and MSCs. We also discuss the critical challenges to be addressed to facilitate the clinical translation of stem cell therapies.
Does Augmented Reality Apps Trigger Loyalty Toward the Brand? A Myth or Reality: The Case of UK and UAE Consumers
Authors: Irshad Waseem , Zhou Erhua , Rasheed Hafiz Muhammad Wasif , Mumtaz Muhammad Usman , Khurshid Rashid 
Published: February 2025

ABSTRACTWith the growing integration of digital innovations in retail, a critical challenge persists: how can augmented reality (AR) applications be utilized to entice the intended target markets to engage and remain loyal? To this end, this study aims to bridge this gap by analyzing the effects of AR‐based apps on consumers' brand loyalty in the beauty goods sector with specific reference to the UK and the UAE. Using the S‐O‐R framework as the theoretical framework of the research, the study examines the influence of experiential values such as playfulness and aesthetics in brand loyalty mediated by customer satisfaction. The results from a questionnaire completed by 550 female AR Mobile App users were examined by testing nine hypotheses. Emphasizing the research findings, it can be further determined that while evaluating the experiential value, there appears to be a significant emphasis on brand loyalty. However, aesthetic value has had minimal influence on consumers within the UAE. Also, AR psychological engagement could have been higher and interacted with satisfaction and brand loyalty in the two regions. Thus, this research extends the understanding of AR research by examining the implications for consumer behavior in the region and providing practical recommendations for managers who want to use AR apps to improve brand loyalty.
Consumer Behavior's Evolution, Emergence, and Future in the AI Age Through the Lens of MR, VR, XR, Metaverse, and Robotics
Authors: Spais George , Jain Varsha 
Published: February 2025

ABSTRACTA critical discussion of the evolution of consumer behavior, ethical consideration, and encouraging the new future directions in the AI era, we highlight the ten main ideas regarding the evolution, emergence, and future of consumer behavior in the AI Age through the lens of immersive technologies and their significance in the changing landscape of consumer behavior research. In light of the significant gaps in understanding how immersive technologies influence consumer behavior, the urgent need for in‐depth knowledge in this area in the AI era is emphasized. Analytically, (1) the literature findings based on critical studies, (2) the connection of several thought‐provoking specific and nuanced research questions, comprehensive theories, frameworks, and contextual examples and suggestions of new frameworks or adaptations for each immersive technology, and (3) the overview of the new research directions, thrusts, and methodological approaches per study area within consumer behavior literature related to metaverse, automation, and robotics serve as a crucial foundation for our objectives and expected contributions of our article. The organization of these ideas logically allows us to see a clear progression from the transformative impact of AI and immersive technologies on consumer behavior to the need for interdisciplinary research and a focus on corporate responsibility in the digital age.
Small‐Diameter Stents in Cardiovascular Applications
Authors: Raj Bhavana , PG Prajitha , Sapa Harika , Shaji Shona Sara , T Sreejith , KP Althaf Umar , K Kaladhar , Varma Praveen 
Published: February 2025

ABSTRACTSmall‐diameter stents play a crucial role in treating congenital heart diseases and variety of vascular conditions that have application from paediatrics to geriatric conditions, and a comprehensive review in this direction is lacking. This review explores historical development, design innovations, material compositions and mechanistic insights into functions of small‐diameter stents, with a specific emphasis on biodegradable options. The necessity for stents that can adapt to growth of paediatric patients is discussed, highlighting the transition from durable polymers to bioresorbable materials such as polylactic acid (PLA) and magnesium alloys. While acknowledging the advancements made in reducing complications like restenosis and thrombosis, the review addresses the challenges that persist, including the need for improved biocompatibility and minimization of late adverse cardiac events associated with certain stent technologies. A detailed examination of various stent generations emphasizes the importance of drug release kinetics, structural integrity and potential for personalized interventions based on patient‐specific factors. The exploration of novel therapeutic compounds, including nanoparticles and interfering RNA, illustrates the ongoing research aimed at enhancing stent efficacy. Ultimately, the review seeks to provide a comprehensive understanding of current landscape while identifying the gaps that future research must address to develop the ideal stent for diverse patient populations.