bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term outcome of patients with proximal left anterior descending coronary artery in‐stent restenosis treated with rotational atherectomy
Authors: Moreno Raúl , García Eulogio , Soriano Javier , Acosta Julio , Abeytua Manuel 
Published: August 2002

AbstractOnce a first interventional procedure has failed, patients with proximal left anterior descending in‐stent restenosis are frequently sent for surgical revascularization. Data on long‐term outcome in selected patients with proximal left anterior descending in‐stent restenosis treated with RA are lacking. The study's objective was to evaluate the long‐term outcome of patients with proximal left anterior descending artery in‐stent restenosis treated with rotational atherectomy. The study population is constituted by 42 patients with proximal left anterior descending in‐stent restenosis treated with rotational atherectomy. Patients were followed up for 2.1 ± 0.9 years (range, 6–54). Restenosis length was 16.5 ± 9.2 mm, and restenosis was diffuse (> 10 mm in length) in 30 (71.4%). The rotational atherectomy procedure was guided by intravascular ultrasound in 18 patients (42.9%). Maximum burr/artery ratio was > 0.7 in 24 (57.1%) patients. One patient suffered a periprocedural non–Q‐wave infarction, but no deaths, Q‐wave infarction, or new target vessel revascularization occurred during hospitalization. There were no deaths or myocardial infarctions after discharge. Sixteen patients (38.1%) needed a new revascularization, but only five (11.9%) underwent coronary bypass grafting at the end of the follow‐up (2.1 ± 0.9 years). The rate of surgical revascularization at 6 months, 1 year, and 3 years was 4.8%, 7.4%, and 18.4%, respectively. The rate of new target vessel revascularization at 6 months, 1 year, and 3 years was 16.7%, 36.5%, and 40.5%, respectively. Patients with ≤ 5 months since stent implantation had a significantly higher rate of new target vessel revascularization. Patients with proximal left anterior descending in‐stent restenosis may be safely treated with rotational atherectomy. This strategy is associated with a very good long‐term outcome, with few patients undergoing surgical revascularization. Cathet Cardiovasc Intervent 2001;52:435–442. © 2001 Wiley‐Liss, Inc.
Severe thrombocytopenia possibly related to readministration of eptifibatide
Authors: Paradiso‐Hardy Fran L. , Madan Mina , Radhakrishnan Sam , Hurden Susan , Cohen Eric A. 
Published: August 2002

AbstractThrombocytopenia following eptifibatide therapy is a rare event, and acute severe thrombocytopenia following readministration has not been reported. We describe a case of acute severe thrombocytopenia following reexposure to eptifibatide during percutaneous coronary intervention. We continue to monitor platelet counts at 2–4 hr and 16–24 hr following administration of any glycoprotein IIb/IIIa inhibitor. Cathet Cardiovasc Intervent 2001;54:63–67. © 2001 Wiley‐Liss, Inc.
Electromechanical assessment of left ventricular function following successful percutaneous coronary revascularization
Authors: Koch Karl‐Christian , Wenderdel Monika , Stellbrink Christoph , Hanrath Peter , vom Dahl Juergen 
Published: August 2002

AbstractPercutaneous electromechanical mapping was applied to evaluate the impact of coronary revascularization on electrical and mechanical parameters in patients with prior myocardial infarction. In 15 patients with prior (≥ 4 weeks) myocardial Q‐wave infarction and regional wall motion abnormalities, left ventricular endocardial mapping was performed immediately prior to percutaneous coronary revascularization. Patients underwent repetitive mapping during 6‐month follow‐up angiography with good revascularization results in all patients. Mean regional unipolar electrogram (UP) amplitude of all regions remained unchanged (10.4 ± 4.2 mV prerevascularization vs. 10.2 ± 4.4 mV postrevascularization), whereas mean local shortening (LS) of all regions increased from 6.0% ± 5.8% to 9.7% ± 5.3% (P < 0.001). The percentage of electromechanical match regions (LS < 6% and UP < 9 mV) remained unchanged after revascularization (15% vs. 10%; NS), whereas the percentage of mismatch regions (LS < 6% and UP > 9 mV) declined from 38% to 10% (P < 0.0001). We conclude that electromechanical mapping allows the sensitive detection of improved mechanical function after successful revascularization. Electrical activity remains unchanged 6 months after revascularization and the number of regions with an electromechanical mismatch decrease. Cathet Cardiovasc Intervent 2001;54:466–472. © 2001 Wiley‐Liss, Inc.
Percutaneous closure of postmyocardial infarction ventricular septal defect with the CcardioSEAL septal occluder implant
Authors: Pienvichit Pavit , Piemonte Thomas C. 
Published: August 2002

AbstractPostinfarction ventricular septal rupture carries a poor prognosis with medical or surgical treatment. We report on successful deployment of CardioSEAL septal occluder implant for postinfarct septal defect in a high‐surgical‐risk patient. Cathet Cardiovasc Intervent 2001;54:490–494. © 2001 Wiley‐Liss, Inc.
Towards multiporphyrinic α‐helices with a polypeptidic backbone as system endowed with light harvesting capabilities
Authors: Solladié Nathalie , Hamel Arnaud , Gross Maurice 
Published: August 2002

AbstractStarting from a porphyrin functionalized derivative of the L‐lysine, three peptides, bearing, respectively, two, four, and eight chromophores, were synthesized using an iterative synthetic strategy based on the choice of mild conditions for the deprotection steps. Chirality 13:736–738, 2001. © 2001 Wiley‐Liss, Inc.
Stereospecific pH‐dependent degradation kinetics of R‐ and S‐naproxen‐β‐l‐O‐acyl‐glucuronide
Authors: Mortensen Rasmus Worm , Sidelmann Ulla Grove , Tjørnelund Jette , Hansen Steen Honoré 
Published: August 2002

AbstractThe hydrolysis and acyl migration of biosynthetic S‐naproxen‐β‐l‐O‐acyl glucuronide (I) and R‐naproxen‐β‐l‐O‐acyl glucuronide (II) was followed by HPLC. Nine first‐order kinetic rate constants for the hydrolysis and acyl migration between the β‐l‐O‐acyl glucuronide, its α/β‐2, α/β‐3‐, α/β‐4‐, and α‐1‐O‐acyl isomers and naproxen aglycone were determined for I and II at pH 7.00, 7.40 and 8.00 at 37°C by kinetic simulation. For I the 3‐O‐acyl isomer was the most stable isomer as the pseudo‐equilibrium ratio for the major acyl‐migrated isomers was 1:1.5:0.9 (2‐O‐acyl isomer:3‐O‐acyl isomer:4‐O‐acyl isomer). The 3‐ and 4‐O‐acyl isomers of II were equally stable as the pseudo‐equilibrium ratio for the major acyl‐migrated isomers was 1:1.4:1.4 (2‐O‐acyl isomer:3‐O‐acyl isomer:4‐O‐acyl isomer). For both I and II, the pseudo‐equilibrium ratio between the major 2‐O‐acyl isomer and the minor α‐l‐O‐acyl isomer was 10:1 (2‐O‐acyl isomer:α‐l‐O‐acyl isomer). The pseudo‐equilibrium found for the major acyl‐migrated isomers of I and II in the present study corresponds with the pattern previously published for R‐ and S‐ketoprofen‐β‐l‐O‐acyl glucuronide acyl‐migrated isomers, suggesting that these findings may be general for acyl‐migrated β‐l‐O‐acyl glucuronides of enantiomeric 2‐arylpropionic acids. Chirality 14:305–312, 2002. © 2002 Wiley‐Liss, Inc.
Enantioselective conjugate addition of diethylzinc to cyclic enones catalyzed by copper complexes of methylene‐bridged P‐chirogenic diphosphines
Authors: Taira Shin'ichi , Crépy Karen V.L. , Imamoto Tsuneo 
Published: August 2002

AbstractThe copper‐catalyzed enantioselective conjugate addition of diethylzinc to 2‐cyclohexen‐1‐one was investigated using (R,R)‐bis‐(t‐butylmethylphosphino)methane (1c) as a chiral ligand. The reaction was carried out at 0°C in THF‐toluene as the solvent system and in the presence of 1.2 mol% of CuOTf afforded (S)‐3‐ethylcyclohexan‐1‐one with 85% ee. Chirality 14:386–392, 2002. © 2002 Wiley‐Liss, Inc.
Video‐microscopy observations of fast dynamic processes in the protozoon Giardia lamblia
Authors: Campanati Loraine , Holloschi Andreas , Troster Helmut , Spring Herbert , Souza Wanderley de , Monteiro‐Leal Luiz Henrique 
Published: August 2002

AbstractVideo‐microscopy in combination with digital image processing was used to analyze dynamic processes associated to the life cycle of Giardia lamblia trophozoites. These parasites swim and attach to the epithelial cells, producing the disease known as Giardiasis. Giardia is a multiflagellar cell, presenting 4 pairs of flagella. With the use of analogue and digital tools, we observed that in cells attached to glass slides only 2 of the 4 pairs present active beating (wave propagation). The frequency observed was 17–18 Hz to the anterior and 8–11 Hz to the ventral flagella. These data resulted from several hours of recording using both analogue video and high‐speed digital camera. The caudal pair did not show active beating patterns and the same holds true for the posterior one. In this latter pair, oscillations were observed, but they were always associated to the transit of the wave produced by the ventral pair. The analysis performed with free moving cells showed that during its forward dislocation, Giardia lamblia presented either a lateral rocking or a complete rotational (tumbling) movement around its longitudinal axis. A dislocation of the caudal region of the cell both in the lateral and dorso‐ventral direction was observed. This movement was completely independent from the flagellar beating and it is likely to be produced by a microtubular complex located in the caudal portion of the cell. The adhesion process of Giardia lamblia was also followed by video‐microscopy and the data showed that the ventral disk had an active participation in this process. Cell Motil. Cytoskeleton 51:213–224, 2002. © 2002 Wiley‐Liss, Inc.
Kinesin‐II is not essential for mitosis and cell growth in Chlamydomonas
Authors: Matsuura Kumi , Lefebvre Paul A. , Kamiya Ritsu , Hirono Masafumi 
Published: August 2002

AbstractThe FLA10 gene product (Fla10p) in Chlamydomonas, a heterotrimeric kinesin‐II, plays a crucial role in flagellar assembly as a motor protein driving intraflagellar transport. This protein has also been suggested to play a role in mitosis based on its localization to mitotic spindle. A role for Fla10p in mitosis has been difficult to test because to date only conditional (temperature‐sensitive) mutant alleles were available, and it is not known whether these retain residual function for mitosis at the non‐permissive temperature. In this report, we describe a null allele of fla10 produced by insertional mutagenesis. This mutant does not assemble flagella, but proliferates at a rate identical to that of wild type cells. Observation of microtubule organization in the cell body revealed that normal mitotic spindles are formed in dividing mutant cells. Thus, we conclude that FLA10 kinesin plays no significant roles in mitosis. Cell Motil. Cytoskeleton 52:195–201, 2002. © 2002 Wiley‐Liss, Inc.
Construction of a NMR‐MOUSE with short dead time
Authors: Anferova S. , Anferov V. , Adams M. , Blümler P. , Routley N. , Hailu K. , Kupferschläger K. , Mallett M.J.D. , Schroeder G. , Sharma S. , Blümich B. 
Published: August 2002

AbstractThe NMR‐MOUSE is a nuclear magnetic resonance (NMR) sensor for unilateral NMR of materials suitable for process and quality control. Practical aspects of the sensor construction are described, in particular radiofrequency coil design and shielding procedures to reduce probe ringing. Dead times of less than 20 μs can be achieved at frequencies in the vicinity of 20 MHz with permanent magnets within sensitive volumes up to 4 mm deep. First applications of the NMR‐MOUSE to the analysis of historical books are reported. © 2002 Wiley Periodicals, Inc. Concepts in Magnetic Resonance (Magn Reson Engineering) 15: 15–25, 2002.
Closed‐loop feedback control of phased‐array microwave heating using thermal measurements from magnetic resonance imaging
Authors: Behnia B. , Suthar M. , Webb A. G. 
Published: August 2002

AbstractMicrowave heating is a promising technique for hyperthermia treatment of tumors, but is not yet a standard clinical method. Problems include the inability to control automatically and noninvasively the temporal and spatial temperature behavior. Magnetic resonance imaging (MRI) can be used to map thermal changes via phase shifts in gradient‐echo images and has recently been incorporated into simple feedback systems for ultrasound heating. In this paper, we show the first demonstration of closed‐loop feedback control of microwave heating using MRI‐derived maps of both temperature and specific absorption rate as the inputs to a feedback algorithm. © 2002 Wiley Periodicals, Inc. Concepts in Magnetic Resonance (Magn Reson Engineering) 15: 101–110, 2002.
Adapting a hall probe controller for current control of an air‐core magnet
Authors: Rinard George A. , Quine Richard W. , Eaton Gareth R. , Eaton Sandra S. 
Published: August 2002

AbstractAir‐core magnets are preferable to iron‐core magnets for electron paramagnetic resonance (EPR) magnetic fields less than ∼150 G (15 mT). The preferred way to control the field of an air‐core magnet is by direct control of the current. For imaging applications, magnetic fields produced by the gradient coils interfere with the use of the Hall sensor. Direct current control of the field avoids this problem. However, most suppliers of commercial EPR spectrometer systems provide only Hall effect control of the magnetic field. To provide direct current control of an air‐coil magnet interfaced to a commercial console, an adapter was constructed that effectively converts the Hall effect probe into a current sensor by measuring the field produced in coils carrying the same current as the main magnet coils, but positioned away from and shielded from the main magnet. The effectiveness of this approach is demonstrated. © 2002 Wiley Periodicals, Inc. Concepts in Magnetic Resonance (Magn Reson Engineering) 15: 47–50, 2002.
Magnet and gradient coil system for low‐field EPR imaging
Authors: Rinard George A. , Quine Richard W. , Eaton Gareth R. , Eaton Sandra S. , Barth Eugene D. , Pelizzari Charles A. , Halpern Howard J. 
Published: August 2002

AbstractAir‐core coils are more practical than iron‐core magnets for producing the required magnetic field distribution for electron paramagnetic resonance imaging at frequencies of a few hundred megahertz. An air‐core, air‐cooled magnet/gradient coil system is presented in this paper, which is optimum in the sense that mathematically it produces fields, which for the number of coils specified, are as uniform (for the magnet) and as linear (for the gradient coils) as is possible over a spherical volume. The magnet is four‐coil (eighth‐order), the z‐coordinate gradient coil system is two‐coil, Maxwell (fifth order), and the transverse gradient coils are four‐coil, Anderson (fifth order). The design tradeoffs included homogeneity and linearity specifications, compatibility with access needed for physiological studies, power requirements, and provisions for rapid scanning. Incremental adjustments of the positions of the magnet coils, based on uniformity measurements, facilitated the meeting of design specifications at a reasonable cost. The 81 cm magnet can operate continuously at 90 G and can scan to 140 G. A 15 cm diameter working volume has a homogeneity of about 40 ppm. Three‐dimensional gradient coils are designed for 10 G/cm. © 2002 Wiley Periodicals, Inc. Concepts in Magnetic Resonance (Magn Reson Engineering) 15: 51–58, 2002.
Early gastric carcinoma with signet ring cell histology
Authors: Hyung Woo Jin , Noh Sung Hoon , Lee Jun Ho , Huh Jihun J. , Lah Ki Hyeok , Choi Seung Ho , Min Jin Sik 
Published: August 2002

AbstractBACKGROUNDThere has been much controversy surrounding the biologic behavior and prognosis of early stage gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of early stage gastric SRC (early SRC), we compared the clinicopathologic features and prognosis of early SRC with other histologic types.METHODSA total of 933 patients with early gastric carcinoma who had undergone gastrectomy from 1987 to 1995 were retrospectively analyzed. Among them, 263 patients with SRC were compared to 670 patients with other histologic types.RESULTSYounger patients more often had SRC than non‐SRC. Additionally, the proportion of females was greater in SRC than in non‐SRC. Signet ring cell carcinoma had a larger proportion of mucosa‐confined lesions and a lower rate of lymph node metastasis than non‐SRC. Even after stratifying the clinicopathologic characteristics, SRC showed a lower rate of lymph node metastasis than non‐SRC. When the lymph node metastasis rate was compared between SRC and undifferentiated histology other than SRC, SRC demonstrated a lower lymph node metastasis rate. Multivariate analysis showed that SRC histology was a negative independent risk factor for lymph node metastasis in early gastric carcinoma. The prognosis of SRC was significantly better than that of non‐SRC (P = 0.0104).CONCLUSIONSEarly gastric carcinoma with SRC is a distinct type of gastric carcinoma in terms of clinicopathologic features and prognosis. The favorable prognosis and lower rate of lymph node metastasis in early SRC suggest that the patients with early gastric carcinoma with SRC could be candidates for less invasive surgeries for an improved quality of life. Cancer 2002;94:78–83. © 2002 American Cancer Society.
Survival after recurrence of Ewing Tumors
Authors: Rodriguez‐Galindo Carlos , Billups Catherine A. , Kun Larry E. , Rao Bhaskar N. , Pratt Charles B. , Merchant Thomas E. , Santana Victor M. , Pappo Alberto S. 
Published: August 2002

AbstractBACKGROUNDDespite improved therapies, 30–40% of patients with Ewing tumors (ET) experience recurrence and have a poor prognosis. The authors analyzed factors prognostic of survival in patients with recurrent ET.METHODSThe authors assessed the relation between postrecurrence survival (PRS) and demographic, disease, and treatment factors in 71 patients who experienced recurrent ET after treatment on one of three consecutive institutional protocols.RESULTSThirty‐four patients (47.9%) had distant recurrence, 25 patients (35.2%) had local recurrence, and 12 patients (16.9%) had both distant and local recurrence at a median of 1.7 years after diagnosis. The probability of 5‐year PRS (± 1 standard error) was 17.7% ± 4.5%. Recurrence ≥ 2 years after diagnosis predicted a significantly better outcome (5‐year PRS, 34.9% ± 8.5%) compared with earlier recurrence (5.0% ± 2.8%; P < 0.001). Patients who had both local and distant recurrence fared worse (5‐year PRS, 12.5% ± 8.3%) compared with patients who had local recurrence alone (21.7% ± 7.8%) or distant recurrence alone (17.6 ± 6.1%). Among patients with local recurrence alone, those who underwent salvage with radical surgery had significantly higher 5‐year PRS estimates (31.4% ± 11.6%) compared with the other patients (9.1% ± 6.1%; P = 0.023). Pulmonary irradiation significantly improved the outcomes of patients with isolated pulmonary recurrence (5‐year PRS estimate, 30.3% ± 12.5% vs. 16.7% ± 10.8%, respectively; P = 0.018).CONCLUSIONSAlthough outcomes are generally poor after patients experience recurrence of ET, certain patient groups differ appreciably in their likelihood of survival. Patients who experience recurrence ≥ 2 years after diagnosis and patients who have local recurrence that can be treated with radical surgery and intensive chemotherapy have the most favorable outcomes. Cancer 2002;94:561–9. © 2002 American Cancer Society.
Lifestyle interference and emotional distress in family caregivers of advanced cancer patients
Authors: Cameron Jill I. , Franche Rene‐Louise , Cheung Angela M. , Stewart Donna E. 
Published: August 2002

AbstractBACKGROUNDProviding end‐of‐life care at home to a family member with advanced cancer can have a negative impact on the emotional well‐being of the family caregiver. The current study examined the impact of providing care on lifestyle and emotional well‐being in a sample of caregivers to patients with advanced cancer. The mediation of lifestyle interference between the amount of care provided and emotional distress was specifically examined.METHODSForty‐four family caregivers participated in a structured quantitative interview. Lifestyle interference was assessed by the Caregiving Impact Scale, amount of care provided was assessed by the Caregiver Assistance Scale, and emotional distress was assessed by the Profile of Mood States—Short Form. Pearson and partial correlations tested whether lifestyle interference mediated the relationship between caregiving assistance and emotional distress. Regression analyses determined overall correlates of emotional distress.RESULTSThree criteria, required to substantiate mediation, were met for total mood disturbance and the depression and tension subscales. An overall regression model identified education level and lifestyle interference to be significant and unique correlates of emotional distress.CONCLUSIONSThe current results suggest that caregivers experience increased emotional distress, regardless of the amount of care provided, when limited in their ability to participate in valued activities and interests. In addition, caregivers with less than a high school education experience more emotional distress. Therefore, helping caregivers maintain valued aspects of their lifestyle should be an important element of home care. Cancer 2002;94:521–7. © 2002 American Cancer Society.
Higher doses of mitoxantrone among men with hormone‐refractory prostate carcinoma
Authors: Levine Ellis G. , Halabi Susan , Roberts John D. , Kaplan Ellen B. , Rago Randall , Atkins James N. , Vogelzang Nicholas J. 
Published: August 2002

AbstractBACKGROUNDMitoxantrone in combination with a low‐dose glucocorticoid has been shown to produce more favorable outcomes among men with hormone‐refractory prostate carcinoma than glucocorticoid alone. Therefore, the authors sought to determine the safety and activity of higher doses of mitoxantrone in combination with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) and a glucocorticoid in preparation for a possible Phase III trial comparing standard to dose‐escalated mitoxantrone.METHODSThis Phase II trial enrolled 45 patients from October 1996 to March 1998. Twenty‐one patients without pelvic irradiation (Arm I) received 21 mg/m2 of mitoxantrone every 3 weeks, and 24 patients who had received pelvic irradiation (Arm II) were given 17 mg/m2 on the same schedule. All patients received 40 mg of hydrocortisone in divided doses daily and GM‐CSF at 500 μg/daily for a minimum of 10 days per cycle beginning on the third day of the cycle.RESULTSIn Arm I, 33% of assessable patients achieved a partial response, 50% had a ≥ 50% decline in their PSA, and 35% had a ≥ 75% decline in PSA values. The comparable numbers in Arm II were 24%, 48%, and 35%, respectively. The median survival times were 12 months in Arm I and 14 months in Arm II. Treatment had to be discontinued in 13% of patients because of thrombocytopenia. No other significant toxicities were encountered.CONCLUSIONSHigher doses of mitoxantrone (17 and 21 mg/m2) were associated with activity comparable to many estramustine combinations and generally were well tolerated. However, because the degree and frequency of thrombocytopenia were greater than that observed with standard dose mitoxantrone (12–14 mg/m2), and because the median survival is apparently comparable to standard dose mitoxantrone, this approach to HRPC cannot be recommended for Phase III testing. Cancer 2002;94:665–72. © 2002 American Cancer Society.DOI 10.1002/cncr.10217