bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of iodine nutritional status on the recurrence of hyperthyroidism and antithyroid drug efficacy in adult patients with Graves’ disease: a systemic review
Authors: Xie Qingxing , Zhang Xinyi , Ma Jinfang , Lu Xi , Zhang Yuwei , Tong Nanwei 
Published: October 2023

AimTo probe the appropriate iodine nutritional status for patients with Graves’disease (GD) hyperthyroidism and on antithyroid drugs (ATD) or after drugwithdrawal.MethodStudies were retrieved from three databases (Embase, Medline, and Cochrane Library) and were screened and evaluated using predefined criteria. The risk of bias of each trial was assessed using a tool from Cochrane. The iodine nutritional status of the subjects was redefined according to the World Health Organization (WHO) criteria and classified as insufficient/adequate/above requirements/excessive iodine intake.ResultTwo randomized controlled trials (RCTs) and 3 observational studies were selected from the 376 retrieved papers, which had different degrees of risk of bias in study design. The heterogeneity among them prevented us from further synthesizing effect indicators and subsequent statistical analyses. Two RCTs with high quality showed that insufficient or above requirements iodine intake was detrimental for ATD-treated GD patients; adequate iodine intake was associated with a lower risk of recurrence and better efficacy in controlling thyrotoxicosis. It could be speculated from three low-quality observational studies that excessive iodine intake may be associated with higher (or similar) recurrence rates and lower remission rates compared to above requirements iodine intake in these patients, but none of them could answer the question of the effect of insufficient or adequate iodine intake on this issue.ConclusionAlthough the available evidence is suboptimal, this systematic review tentatively suggests that in adult patients with GD hyperthyroidism receiving ATDs and according to WHO criteria for iodine nutritional status, adequate iodine intake is associated with a lower recurrence rate, a higher remission rate and a better efficacy to control thyrotoxicosis than insufficient, above requirement, or excessive iodine intake. Future RCTs with large samples are expected to elucidate the actual impact of different iodine nutritional statuses on the recurrence rate of hyperthyroidism and the efficacy of ATD to control thyrotoxicosis in these patients.Systematic review registrationidentifier CRD42022359451.
Incidence of vitamin D deficiency in adolescent idiopathic scoliosis: a meta-analysis
Authors: Llopis-Ibor Clara Inés , Mariscal Gonzalo , de la Rubia Ortí Jose Enrique , Barrios Carlos 
Published: October 2023

IntroductionThis study aimed to investigate the incidence of vitamin D deficiency in patients with adolescent idiopathic scoliosis through a meta-analysis and to analyze trends and risk factors.MethodsPotentially relevant studies were searched using the terms “Vitamin D AND scoliosis.” Data on the incidence and risk factors, such as race, curve magnitude, and sex, were extracted from the selected studies. Review Manager 5.4 software was used for the data analysis. Six studies with a total of 1, 428 patients met the inclusion criteria.ResultsThe incidence of vitamin D insufficiency in patients with idiopathic scoliosis was 36.19% (95% CI [21.93 to 50.46]. In contrast, the incidence of vitamin D deficiency was 41.43% (95% CI [16.62 66.23]. Vitamin D levels were compared between Caucasian and African patients and it was concluded that Caucasian patients had a lower risk of vitamin D deficiency [RR 0.15, 95% CI (0.03 to 0.82; P = 0.03]. There was also an association between patients with idiopathic scoliosis and lower vitamin D -5.58, 95% CI [-7.10, -4.06]. Finally, no significant differences were observed in terms of curve magnitude assessed with the Cobb angle mean difference (MD) 4.45, 95% CI [-0.55, 9.44], or sex with lower-than-normal levels of vitamin D OR 0.96, 95% CI [0.58 to 1.60].DiscussionThe incidence rates of vitamin D insufficiency and deficiency in patients with adolescent idiopathic scoliosis were 36.19% and 41.43%, respectively. The Caucasian race was associated with a lower risk of vitamin D deficiency compared to the African race. Vitamin D deficiency was not related to curve magnitude or sex.
Kappa free light chains index in multiple sclerosis very long-term prognosis
Authors: Arroyo-Pereiro Pablo , García-Serrano Lydia , Morandeira Francisco , Urban Blanca , Mas Virginia , Framil Mario , León Isabel , Muñoz-Vendrell Albert , Matas Elisabet , Romero-Pinel Lucía , Martínez-Yélamos Antonio , Martínez-Yélamos Sergio , Bau Laura 
Published: October 2023

IntroductionThe role of the kappa-free light chain (kFLC) in the diagnosis of multiple sclerosis (MS) and, to a lesser extent, its role as a medium-term prognostic marker have been extensively studied. This study aimed to explore its potential as a long-term prognostic marker for MS.MethodsWe performed an exploratory retrospective observational study by selecting patients systemically followed up in our MS unit with available cerebrospinal fluid and serum samples at the time of initial evaluation. Two groups were defined: benign MS (bMS), defined as patients with Expanded Disability Status Scale (EDSS) ≤ 3 at 10 years of follow-up, and aggressive MS (aMS), defined as patients with EDSS ≥ 6 at 15 years of follow-up. Clinical variables were collected, and the immunoglobulin G (IgG) index, kFLC index, and oligoclonal bands (OCB) were determined for all patients and compared between the groups.ResultsTwenty bMS and 15 aMS patients were included in this study. Sixty percent (21/35) were female, and the mean age at the time of the first symptom was 31.5 ± 9.45 years, with no statistical differences between groups. Median follow-up time was 19.8 years (Interquartile range, IQR 15.9–24.6). The median EDSS scores at the last follow-up were 1.5 and 7.5 in the bMS and the aMS group, respectively. No statistically significant differences were found in the kFLC index between the two groups (136.6 vs. 140.27, p=0.59). The IgG index was positive in 62.9% of patients (55% bMS vs. 73.3% aMS, p&gt;0.05), and OCB was positive in 88.6% (90% bMS vs. 86.7% aMS, p&gt;0.05). A significant positive correlation was found between IgG and kFLC indices (rs = 0.85, p&lt;0.001).ConclusionGiven the absence of differences between the two groups with opposite disease courses, it is unlikely that the kFLC index is a reliable and powerful marker of long-term prognosis in MS.
Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2
Authors: Ihedioha Olivia C. , Sivakoses Anutr , Beverley Stephen M. , McMahon-Pratt Diane , Bothwell Alfred L. M. 
Published: October 2023

BackgroundPlatelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a quintessential Wnt antagonist produced by a variety of cell types including platelets, endothelial cells, and is known to modulate pro-inflammatory responses in infectious diseases and cancer. Moreover, DKK1 is critical for forming leukocyte-platelet aggregates and induction of type 2 cell-mediated immune responses. Our previous publication showed activated platelets release DKK1 following Leishmania major recognition.ResultsHere we probed the role of the key surface virulence glycoconjugate lipophosphoglycan (LPG), on DKK1 production using null mutants deficient in LPG synthesis (Δlpg1- and Δlpg2-). Leishmania-induced DKK1 production was reduced to control levels in the absence of LPG in both mutants and was restored upon re-expression of the cognate LPG1 or LPG2 genes. Furthermore, the formation of leukocyte-platelet aggregates was dependent on LPG. LPG mediated platelet activation and DKK1 production occurs through TLR1/2.ConclusionThus, LPG is a key virulence factor that induces DKK1 production from activated platelets, and the circulating DKK1 promotes Th2 cell polarization. This suggests that LPG-activated platelets can drive innate and adaptive immune responses to Leishmania infection.
Aspartate metabolic flux promotes nitric oxide to eliminate both antibiotic-sensitive and -resistant Edwardsiella tarda in zebrafish
Authors: Xiang Jiao , Li Min-yi , Li Hui 
Published: October 2023

IntroductionMetabolic reprogramming potentiates host protection against antibiotic-sensitive or -resistant bacteria. However, it remains unclear whether a single reprogramming metabolite is effective enough to combat both antibiotic-sensitive and -resistant bacteria. This knowledge is key for implementing an antibiotic-free approach.MethodsThe reprogramming metabolome approach was adopted to characterize the metabolic state of zebrafish infected with tetracycline-sensitive and -resistant Edwardsiella tarda and to identify overlapping depressed metabolite in dying zebrafish as a reprogramming metabolite.ResultsAspartate was identify overlapping depressed metabolite in dying zebrafish as a reprogramming metabolite. Exogenous aspartate protects zebrafish against infection caused by tetracycline-sensitive and -resistant E. tarda. Mechanistically, exogenous aspartate promotes nitric oxide (NO) biosynthesis. NO is a well-documented factor of promoting innate immunity against bacteria, but whether it can play a role in eliminating both tetracycline-sensitive and -resistant E. tarda is unknown. Thus, in this study, aspartate was replaced with sodium nitroprusside to provide NO, which led to similar aspartate-induced protection against tetracycline-sensitive and -resistant E. tarda.DiscussionThese findings support the conclusion that aspartate plays an important protective role through NO against both types of E. tarda. Importantly, we found that tetracycline-sensitive and -resistant E. tarda are sensitive to NO. Therefore, aspartate is an effective reprogramming metabolite that allows implementation of an antibiotic-free approach against bacterial pathogens.
Analysis of patients’ privacy and associated factors in the perioperative period
Authors: Tan Mingyang , Li Hongyu , Wang Xiaofei 
Published: October 2023

BackgroundHealthcare professionals recognize how to protect patient privacy in order to effectively reduce the occurrence of conflict between the two parties. Therefore, understanding the protection of patient privacy during the perioperative period and the relevant factors affecting privacy is essential to improving healthcare delivery.MethodsThis was a cross-sectional survey of a convenience sample of 400 perioperative patients. General demographic information, the perioperative privacy scale (PPS), and the Amsterdam preoperative anxiety and information scale (APAIS) were used for the survey. And factors affecting patient privacy were investigated by ANOVA or t-test analysis, Pearson correlation analysis, and linear regression models.ResultsThis study found that perioperative patient privacy satisfaction scores were (53.51 ± 12.54). The results of the univariate analysis showed that factors affecting privacy satisfaction included gender, age, and the number of surgeries (p &lt; 0.05). Preoperative anxiety and Information Needs Scale was negatively associated with the perioperative patient privacy satisfaction (r = −0.807, p &lt; 0.01). Further analysis was performed using linear regression models to finally obtain five factors affecting perioperative patient privacy: gender, age, anesthesia modality, the number of surgeries, and the Amsterdam preoperative anxiety and information.ConclusionHealthcare professionals working in healthcare facilities need to be aware of the sensitivity of different populations to privacy when protecting patient privacy. Patients’ preoperative anxiety and information need status affect privacy satisfaction. This will mean that healthcare professionals will be able to identify key privacy concerns early and take appropriate action.
Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies
Authors: Kalamara Tsampika-Vasileia , Dodos Konstantinos , Vlachaki Efthymia 
Published: October 2023

IntroductionThromboembolism (TE) and pulmonary hypertension (PH) constitute frequently occurring complications in patients with transfusion-dependent thalassemia and have been associated with splenectomy in different studies. Nevertheless, the size of the possible association varies greatly in literature. Herein, we sought to provide pooled effect estimates regarding the impact of splenectomy on TE and PH in transfusion dependent thalassemia (TDT) by retrieving relevant, available studies.MethodsWe systematically searched articles published in PubMed, Cochrane library, Scopus and gray literature from inception until the 30th of May, 2023. Pooled estimates in terms of odds ratios (OR) and 95% confidence intervals (CI) were calculated according to outcome measures. Risk of bias and quality of studies were evaluated.ResultsRegarding TE, 4 studies were selected for meta-analysis and the pooled data demonstrated that splenectomy was significantly associated with this outcome in TDT patients [OR = 4.08, 95% CI (1.03, 16.11), p = 0.04]. On the other hand, we pooled data from seven investigating PH, and, interestingly, the quantitative analysis revealed no association between splenectomy and PH [OR = 1.76, 95% CI (0.91, 3.41), p = 0.1].ConclusionSplenectomy is associated with higher risks of TE, but not with PH in patients with TDT.
Assessing the diagnostic accuracy of CT perfusion: a systematic review
Authors: Thirugnanachandran Tharani , Aitchison Sean G. , Lim Andy , Ding Catherine , Ma Henry , Phan Thanh 
Published: October 2023

Background and purposeComputed tomography perfusion (CTP) has successfully extended the time window for reperfusion therapies in ischemic stroke. However, the published perfusion parameters and thresholds vary between studies. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy Studies (PRISMA-DTA) guidelines, we conducted a systematic review to investigate the accuracy of parameters and thresholds for identifying core and penumbra in adult stroke patients.MethodsWe searched Medline, Embase, the Cochrane Library, and reference lists of manuscripts up to April 2022 using the following terms “computed tomography perfusion,” “stroke,” “infarct,” and “penumbra.” Studies were included if they reported perfusion thresholds and undertook co-registration of CTP to reference standards. The quality of studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool and Standards for Reporting of Diagnostic Accuracy (STARD) guidelines.ResultsA total of 24 studies were included. A meta-analysis could not be performed due to insufficient data and significant heterogeneity in the study design. When reported, the mean age was 70.2 years (SD+/−3.69), and the median NIHSS on admission was 15 (IQR 13–17). The perfusion parameter identified for the core was relative cerebral blood flow (rCBF), with a median threshold of &lt;30% (IQR 30, 40%). However, later studies reported lower thresholds in the early time window with rapid reperfusion (median 25%, IQR 20, 30%). A total of 15 studies defined a single threshold for all brain regions irrespective of collaterals and the gray and white matter.ConclusionA single threshold and parameter may not always accurately differentiate penumbra from core and oligemia. Further refinement of parameters is needed in the current era of reperfusion therapy.
Cognitive neural responses in the semantic comprehension of sound symbolic words and pseudowords
Authors: Sasaki Kaori , Kadowaki Seiichi , Iwasaki Junya , Pijanowska Marta , Okamoto Hidehiko 
Published: October 2023

IntroductionSound symbolism is the phenomenon of sounds having non-arbitrary meaning, and it has been demonstrated that pseudowords with sound symbolic elements have similar meaning to lexical words. It is unclear how the impression given by the sound symbolic elements is semantically processed, in contrast to lexical words with definite meanings. In event-related potential (ERP) studies, phonological mapping negativity (PMN) and N400 are often used as measures of phonological and semantic processing, respectively. Therefore, in this study, we analyze PMN and N400 to clarify the differences between existing sound symbolic words (onomatopoeia or ideophones) and pseudowords in terms of semantic and phonological processing.MethodsAn existing sound symbolic word and pseudowords were presented as an auditory stimulus in combination with a picture of an event, and PMN and N400 were measured while the subjects determined whether the sound stimuli and pictures match or mismatch.ResultsIn both the existing word and pseudoword tasks, the amplitude of PMN and N400 increased when the picture of an event and the speech sound did not match. Additionally, compared to the existing words, the pseudowords elicited a greater amplitude for PMN and N400. In addition, PMN latency was delayed in the mismatch condition relative to the match condition for both existing sound symbolic words and pseudowords.DiscussionWe concluded that established sound symbolic words and sound symbolic pseudowords undergo similar semantic processing. This finding suggests that sound symbolism pseudowords are not judged on a simple impression level (e.g., spiky/round) or activated by other words with similar spellings (phonological structures) in the lexicon, but are judged on a similar contextual basis as actual words.
Study on the metabolic process of phthalic acid driven proliferation of Rhizoctonia solani
Authors: Ju Jidong , Zhou Bingqian , Yang Guohong , Fu Xinyu , Wang Xiao , Guo Lanping , Liu Wei 
Published: October 2023

IntroductionContinuous cropping obstacle seriously affects the quality and yield of Salvia miltiorrhiza, and the synergistic effect of root exudates and rhizosphere pathogenic microorganisms may be an important cause of continuous cropping obstacle. This study aimed to explore the effects of representative organic acids on the growth and metabolism of specific microorganisms in the S. miltiorrhiza rhizosphere soil under continuous cropping, and clarify its mechanism.MethodsThe effect of phthalic acid (PA) on the growth and metabolism of Rhizoctonia solani was evaluated by mycelial growth inhibition method. Ultra-high performance liquid chromatography and tandem mass spectrometry were used to identify the differential metabolites of R. solani induced by exogenous PA.ResultsPA exerted a concentration-dependent effect on mycelial growth, biomass, intracellular polysaccharides con-tent, and total protein content in R. solani. A total of 1773 metabolites and 1040 differential metabolites were identified in the blank medium (CK), Fungi (CK + fungi), and PA-Fungi (CK + fungi + acid) groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the differential metabolites were mainly involved in the sugar, lipid, and protein metabolic pathways related to stable membrane structure and cell growth.DiscussionThe proliferation and metabolism network of R. solani induced by PA was proposed, and the enhancement of sugar, lipid, and amino acid metabolism was presumed to be related to the active resistance of cells to organic acid stress. These results offer new in-sights into the effects of PA metabolism on promoting R. solani proliferation, and provide theoretical support for further optimizing the rhizosphere microecological environment of Salvia miltiorrhiza continuous cropping soil and reducing continuous cropping obstacle.
Case report: Spontaneous mandibular body regeneration following unilateral subtotal mandibulectomy in a 3-month-old French bulldog
Authors: Wright Alexandra L. , Peralta Santiago , Fiani Nadine 
Published: October 2023

ObjectiveTo document a case of spontaneous regeneration of the mandibular body following subtotal mandibulectomy in a juvenile dog.Case summaryA 3-month-old male intact French bulldog was presented with papillary oral squamous cell carcinoma located at the dorsal aspect of the molar region of the left mandible. Initial biopsy of the mass was performed by the primary care veterinarian. Complete clinical staging revealed no signs of metastasis. Computed tomographic images of the head showed minimal contrast enhancement of the mass with no signs of periosteal or bone involvement. Subtotal mandibulectomy was performed. Histopathology indicated complete excision of the tumor. The patient returned 8-weeks later for follow up and cleft palate surgical repair, at which time bone was noted in the mandibulectomy area on palpation. Repeat computed tomography of the head revealed complete regeneration of the left mandibular body from the level of the ramus to the mandibular symphysis. No treatment for malocclusion was necessary due to the reformation of a functional mandible.Clinical relevanceThe present case demonstrates that spontaneous regeneration of the mandibular body is possible following subtotal mandibulectomy in immature dogs. Subtotal mandibulectomy is a radical procedure that can lead to long term complications including mandibular drift, malocclusion, and oral pain. This case report provides evidence that these sequelae may be mitigated or eliminated in young patients undergoing this procedure.
PENGARUH PENERAPAN APLIKASI “BIDANKU” TERHADAP PENINGKATAN PENGETAHUAN DAN EFIKASI DIRI IBU NIFAS
Authors: Farhati Farhati , Fatimah Yulia Ulfah , Sriyanti Chris 
Published: October 2023

Periode postpartum merupakan periode kritis bagi ibu, sekitar 60% kematian ibu terjadi setelah melahirkan, dan 50% kematian postpartum terjadi dalam 24 jam pertama persalinan. Masa ini merupakan masa transisi yang penting, namun dalam perawatan kesehatan wanita, ini menjadi aspek yang sering diabaikan. Persiapan masa nifas yang tidak diberikan sejak masa kehamilan, menyebabkan ibu tidak mengetahui cara perawatan diri dan bayinya dengan baik. Salah satu jembatan untuk mengoptimalkan upaya edukasi postnatal adalah melalui pengembangan aplikasi “Bidanku” yang berisi informasi dan manajemen perawatan yang dapat digunakan sebagai panduan bagi ibu nifas, sehingga dapat menjalani masa nifas dengan sehat, selamat, dan sejahtera. Tujuan penelitian ini adalah menganalisis pengaruh penerapan aplikasi “bidanku” terhadap peningkatan pengetahuan dan efikasi diri ibu nifas. Penelitian ini merupakan penelitian quasi eksperimen pre-post test design with control groups yang dilakukan di Kota Bandung dengan subjek ibu nifas yang terdiri dari kelompok intervensi dan kontrol dengan masing-masing sampel sejumlah 30 ibu nifas. Analisis menggunakan uji Mann Whitney untuk kelompok tidak berpasangan dan uji Wilcoxon untuk kelompok berpasangan. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang bermakna pengetahuan dan efikasi diri ibu nifas antara kelompok kontrol dan perlakuan dengan nilai p<0,05. Aplikasi “Bidanku” dapat dijadikan alternatif media edukasi dalam asuhan kebidanan pada ibu nifas.