bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research protocol of the Laval-ROSA Transilab: a living lab on transitions for people living with dementia
Authors: Dufour Isabelle , Arsenault-Lapierre Geneviève , Guillette Maxime , Dame Nathalie , Poitras Marie-Eve , Lussier Marie-Thérèse , Fortier Annie , Brunet Julie , Martin Julie , Laverdure Micheline , Brousseau Ginette , Bergman Howard , Couturier Yves , Quesnel-Vallée Amélie , Vedel Isabelle 
Published: November 2023

Abstract
Background
The Laval-ROSA Transilab is a living lab that aims to support the Laval Integrated Health and Social Services Centres (Quebec, Canada) in consolidating the Quebec Alzheimer Plan. It aims to improve care transitions between different settings (Family Medicine Groups, home care, and community services) and as such improve the care of people living with dementia and their care partners. Four transition-oriented innovations are targeted. Two are already underway and will be co-evaluated: A) training of primary care professionals on dementia and interprofessional collaboration; B) early referral process to community services. Two will be co-developed and co-evaluated: C) developing a structured communication strategy around the dementia diagnosis disclosure; D) designation of a care navigator from the time of dementia diagnosis. The objectives are to: 1) co-develop a dashboard for monitoring transitions; 2) co-develop and 3) co-evaluate the four targeted innovations on transitions. In addition, we will 4) co-evaluate the impact and implementation process of the entire Laval-ROSA Transilab transformation, 5) support its sustainability, and 6) transfer it to other health organizations.

Methods
Multi-methods living lab approach based on the principles of a learning health system. Living labs are open innovation systems that integrate research co-creation and knowledge exchange in real-life settings. Learning health systems centers care improvement on developing the organization's capacity to learn from their practices. We will conduct two learning cycles (data to knowledge, knowledge to practice, and practice to data) and involve various partners. We will use multiple data sources, including health administrative databases, electronic health records data, surveys, semi-structured interviews, focus groups, and observations.

Discussion
Through its structuring actions, the Laval-ROSA Transilab will benefit people living with dementia, their care partners, and healthcare professionals. Its strategies will support sustainability and will thus allow for improvements throughout the care continuum so that people can receive the right services, at the right time, in the right place, and from the right staff.
Predicting micropapillary or solid pattern of lung adenocarcinoma with CT-based radiomics, conventional radiographic and clinical features
Authors: Wang Zhe , Zhang Ning , Liu Junhong , Liu Junfeng 
Published: November 2023

Abstract
Background
To build prediction models with radiomics features, clinical/conventional radiographic signs and combined scores for the discrimination of micropapillary or solid subtypes (high-risk subtypes) of lung adenocarcinoma.

Methods
This retrospective study enrolled 351 patients with and without high-risk subtypes. Least Absolute Shrinkage and Selection Operator (LASSO) regression with cross-validation was performed to determine the optimal features of radiomics model. Missing clinical data were imputed by Multiple Imputation with Chain Equations (MICE). Clinical model with radiographic signs was built and scores of both models were integrated to establish combined model. Receiver operating characteristics (ROC) curves, area under ROC curves and decision curve analysis (DCA) were plotted to evaluate the model performance and clinical application.

Results
Stratified splitting allocated 246 patients into training set. MICE for missing values obtained complete and unbiased data for the following analysis. Ninety radiomic features and four clinical/conventional radiographic signs were used to predict the high-risk subtypes. The radiomic model, clinical model and combined model achieved AUCs of 0.863 (95%CI: 0.817–0.909), 0.771 (95%CI: 0.713–0.713) and 0.872 (95%CI: 0.829–0.916) in the training set, and 0.849 (95%CI: 0.774–0.924), 0.778 (95%CI: 0.687–0.868) and 0.853 (95%CI: 0.782–0.925) in the test set. Decision curve showed that the radiomic and combined models were more clinically useful when the threshold reached 37.5%.

Conclusions
Radiomics features could facilitate the prediction of subtypes of lung adenocarcinoma. A simple combination of radiomics and clinical scores generated a robust model with high performance for the discrimination of micropapillary or solid subtype of lung adenocarcinoma.
Simultaneous upper and lower body perfusion using hypothermia during thoracoabdominal aortic surgery
Authors: Kise Yuya , Kuniyoshi Yukio , Ando Mizuki , Miyaishi Keita , Higa Shotaro , Maeda Tatuya , Nakaema Moriyasu , Inafuku Hitoshi , Furukawa Kojiro 
Published: November 2023

Abstract
Background
In open thoracoabdominal aortic aneurysm (TAAA) repair, we have been performing vascular reconstruction under moderate to deep hypothermia and assisted circulation using simultaneous upper and lower body perfusion. This method is effective for protecting the spinal cord and the brain, heart, and abdominal organs and for avoiding lung damage.

Methods
TAAA repair was performed under hypothermia at 20–28 °C in 18 cases (Crawford type I in 0 cases, type II in 5, type III in 3, type IV in 4, and Safi V in 6) between October 2014 and January 2023. Cardiopulmonary bypass was conducted by combined upper and lower body perfusion, with perfusion both via the femoral artery and either transapically or via the descending aorta or the left brachial artery.

Results
The ischemic time for the artery of Adamkiewicz and the main segmental arteries was 40–124 min (75 ± 33 min). No spinal cord ischemic injury or brain or heart complications occurred. One patient with postoperative right renal artery occlusion and one with an infected aneurysm required tracheostomy, but the intubation time for the other 16 was 32 ± 33 h. The duration of postoperative intensive care unit stay was 6.5 ± 6.2 days, the length of hospital stay was 29 ± 15 days, and no in-hospital deaths occurred.

Conclusions
Simultaneous upper and lower body perfusion under moderate to deep hypothermia during thoracoabdominal aortic surgery may avoid not only spinal cord injury, but also cardiac and brain complications.
An anatomical approach to the tarsal tunnel syndrome: what can ankle's medial side anatomy reveal to us?
Authors: Lopes Jorge Gomes , Rodrigues‐Pinho André , Neves Maria Abreu , Pinto Filipe Fonseca , Relvas‐Silva Miguel , Vital Luísa , Serdoura Francisco , Nogueira‐Sousa António , Madeira Maria Dulce , Pereira Pedro Alberto 
Published: November 2023

AbstractBackgroundThe heel is a complex anatomical region and is very often the source of pain complaints. The medial heel contains a number of structures, capable of compressing the main nerves of the region and knowing its anatomical topography is mandatory. The purpose of this work is to evaluate if tibial nerve (TN) and its main branches relate to the main anatomical landmarks of the ankle's medial side and if so, do they have a regular path after emerging from TN.MethodsThe distal part of the legs, ankles and feet of 12 Thiel embalmed cadavers were dissected. The pattern of the branches of the TN was registered and the measurements were performed according to the Dellon–McKinnon malleolar‐calcaneal line (DML) and the Heimkes Triangle (HT).ResultsThe TN divided proximal to DML in 87.5%, on top of the DML in 12,5% and distal in none of the feet. The Baxter's nerve (BN) originated proximally in 50%, on top of the DML in 12,5% and distally in 37.5% of the cases. There was a strong and significant correlation between the length of DML and the distance from the center of the medial malleolus (MM) to the lateral plantar nerve (LPN), medial plantar (MPN) nerve, BN and Medial Calcaneal Nerve (MCN) (ρ: 0.910, 0.866, 0.970 and 0.762 respectively, p <  0.001).ConclusionsIn our sample the TN divides distal to DML in none of the cases. We also report a strong association between ankle size and the distribution of the MPN, LPN, BN and MCN. We hypothesize that location of these branches on the medial side of the ankle could be more predictable if we take into consideration the distance between the MM and the medial process of the calcaneal tuberosity.
Professional prehospital clinicians’ experiences of ethical challenges associated with the collaboration with organised voluntary first responders: a qualitative study
Authors: Sørensen Oliver Beierholm , Milling Louise , Laerkner Eva , Mikkelsen Søren , Bruun Henriette 
Published: November 2023

Abstract
Background
Volunteer First Responders are used worldwide. In the Region of Southern Denmark, two types of programs have been established. One of these programs consists of voluntary responders without any requirements of education or training who are summoned to prehospital cardiac arrests. The other type of program is established primarily in the rural areas of the region and consists of volunteers with some mandatory education in first aid. These volunteers are summoned to all urgent cases along with the ambulances. Cooperation between professional healthcare workers and nonprofessionals summoned through official channels may be challenging. This study aimed to explore prehospital clinicians’ experiences of ethical challenges in cooperation with volunteer first responders.

Methods
We conducted 16 semi-structured interviews at four different ambulance stations in the Region of Southern Denmark. Five emergency physicians and 11 emergency medical technicians/paramedics were interviewed. The interviews were transcribed, and the data were analysed using systematic text condensation.

Results
The study's 16 interviews resulted in the identification of some specific categories that challenged the cooperation between the two parties. We identified three main categories: 1. Beneficence, the act of doing good, 2. The risk of harming patients’ autonomy 3. Non-maleficence, which is the obligation not to inflict harm on others.

Conclusion
This study provides an in-depth insight into the ethical challenges between prehospital clinicians and voluntary first responders from the perspective of the prehospital clinicians. Both programs are considered to have value but only when treating patients with cardiac arrest. Our study highlights potential areas of improvement in the two Danish voluntary programs in their current form.
Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors
Authors: Snyder Mackenzie , Njie Binta Y. , Grabenstein Ilana , Viola Sara , Abbas Hatoon , Bhatti Waqas , Lee Ryan , Traficante Rosalie , Yeung Siu Yan Amy , Chow Jonathan H. , Tabatabai Ali , Taylor Bradley S. , Dahi Siamak , Scalea Thomas , Rabin Joseph , Grazioli Alison , Calfee Carolyn S. , Britton Noel , Levine Andrea R. 
Published: November 2023

Abstract
Background
The mortality benefit of VV-ECMO in ARDS has been extensively studied, but the impact on long-term functional outcomes of survivors is poorly defined. We aimed to assess the association between ECMO and functional outcomes in a contemporaneous cohort of survivors of ARDS.

Methods
Multicenter retrospective cohort study of ARDS survivors who presented to follow-up clinic. The primary outcome was FVC% predicted. Univariate and multivariate regression models were used to evaluate the impact of ECMO on the primary outcome.

Results
This study enrolled 110 survivors of ARDS, 34 of whom were managed using ECMO. The ECMO cohort was younger (35 [28, 50] vs. 51 [44, 61] years old, p < 0.01), less likely to have COVID-19 (58% vs. 96%, p < 0.01), more severely ill based on the Sequential Organ Failure Assessment (SOFA) score (7 [5, 9] vs. 4 [3, 6], p < 0.01), dynamic lung compliance (15 mL/cmH20 [11, 20] vs. 27 mL/cmH20 [23, 35], p < 0.01), oxygenation index (26 [22, 33] vs. 9 [6, 11], p < 0.01), and their need for rescue modes of ventilation. ECMO patients had significantly longer lengths of hospitalization (46 [27, 62] vs. 16 [12, 31] days, p < 0.01) ICU stay (29 [19, 43] vs. 10 [5, 17] days, p < 0.01), and duration of mechanical ventilation (24 [14, 42] vs. 10 [7, 17] days, p < 0.01). Functional outcomes were similar in ECMO and non-ECMO patients. ECMO did not predict changes in lung function when adjusting for age, SOFA, COVID-19 status, or length of hospitalization.

Conclusions
There were no significant differences in the FVC% predicted, or other markers of pulmonary, neurocognitive, or psychiatric functional recovery outcomes, when comparing a contemporaneous clinic-based cohort of survivors of ARDS managed with ECMO to those without ECMO.
Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst
Authors: Sherafati Alireza , Moradi Shahram , Mahdavi Mohammad 
Published: November 2023

AbstractIn this pared, an efficient method is introduced for the synthesis of 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives. These novel products have both 1,2,3-triazole and quinazolinone in their structures. For the synthesis of these products, a novel catalyst is designed, synthesized, and characterized by the immobilization of copper onto modified magnetic iron oxide. The catalyst (denoted: Cu@Py-Oxa@SPION) was characterized by several characterization techniques. In this regard, 16 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized in high isolated yields (77–86%). As an advantage, the catalyst is highly recoverable and its activity has not decreased after 7 sequential runs. The method is very efficient for the synthesis of the products in high isolated yields under mild reaction conditions in a green solvent. The scope of the method is broad and several examples were successfully synthesized using starting materials with different functional groups.
Effect of exercise interventions based on family management or self-management on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Dong Chenyang , Liu Ruoya , Huang Zhiyang , Yang Yang , Sun Shiyuan , Li Ran 
Published: November 2023

Abstract
Background
Most studies about exercise interventions for patients with type 2 diabetes mellitus (T2DM) have been conducted in hospitals or labs, but it is unclear whether study findings from this specific condition can be generalised to real-life T2DM communities. If patients with T2DM can exercise on their own or with family members, it may also reduce the need for patient supervision by medical staff, thereby reducing the burden of medical treatment and improving condition management's cost-effectiveness and practicability. Much of the current research on exercise interventions for T2DM was focused on the type of exercise and less on the mode of management, so we aimed to examine the effect of exercise interventions based on family management or self-management on glycaemic control in patients with T2DM.

Methods
Articles were searched from eight Chinese and English databases. Randomized control trials (RCTs) published in English and Chinese, from inception to October 17, 2022, were included in this review. The methodological quality of the included studies was assessed using the RCT risk of bias assessment tool provided by the Cochrane Collaboration’s tool. Meta-analysis was performed using Rev Man 5.4 and Stata 15.0 software. Heterogeneity was investigated using sensitivity analysis and subgroup analyses. Publication bias was tested by funnel plot and Egger's asymmetry tests.

Results
A total of 10 studies with a total of 913 subjects were finally included in this review. The Meta-analysis showed that exercise interventions based on family management or self-management were more effective than control groups in reducing HbA1c (Z = 3.90; 95% CIMD = − 0.81; − 1.21 to − 0.40; P < 0.0001), fasting glucose (Z = 4.63; 95% CI MD = − 1.17; − 1.67 to − 0.68; P < 0.00001), 2-h plasma glucose (Z = 5.53; 95% CI MD = − 1.84; − 2.50 to − 1.19; P < 0.00001), and Low-density lipoproteins levels (Z = 3.73; 95% CIMD = − 0.38; − 0.58 to − 0.18; P = 0.0002).

Conclusions
Exercise interventions based on family management or self-management can significantly reduce glycosylated haemoglobin, fasting glucose, 2-h plasma glucose, and Low-density lipoproteins levels in patients with T2DM, which can effectively delay disease progression and reduce the risk of developing complications. In the future, for exercise interventions based on family or self-management, this review recommended that exercise intervention programmes should be formulated according to 30–60 min per session, more than three times per week, for more than six months of aerobic exercise or aerobic combined with resistance exercise.
A novel tetra-primer ARMS-PCR for genotyping of the OPRM1 gene rs1799971 variant associated with opioid use disorders
Authors: Wijekumar P. J. , Ranadeva N. D.K. , Jayamaha A. R. , Herath H. M.N.D.M. , Noorden N. , Fernando S. S.N. 
Published: November 2023

Abstract
Objectives
A SNV is a single nucleotide change that can occur at any point in the genome. SNVs are the most common genetic variants that occur in the human genome, and a number of SNVs have been found to be associated with human traits and disease. Researchers genotype SNVs using TaqMan technology, DNA microarray, MALDI-TOF mass spectrometry, and automated sequencing, which are expensive and time-consuming. The OPRM1 gene rs1799971 (A118G) has been identified for its association with Opioid use disorder (OUD). The present study focused on developing a single step identification test using Tetra-Primer Amplification Refractory Mutation System-PCR (T-ARMS-PCR) to detect the presence of SNV OPRM1 rs1799971 (A118G). This study was performed to optimize the protocol for the designed four primers and validate it using a total of 52 buccal samples from volunteers who are currently under rehabilitation for the drug abuse disorder.

Results
Utilizing 52 DNA samples, a novel T-ARMS-PCR assay was successfully developed, tested, and validated. The products of the T-ARMS PCR for rs1799971 contained 395 bp as the control band, 186 bp as G allele (variant) and 257 bp as A allele (wild type), which were observed in the gel image. The genotype frequencies for the OPRM1 gene rs1799971 (A118G) were 44% (22/52) of homozygous variant type (GG), 28.9% (15/52) of homozygous wild type (AA) and 28.9% (15/22) of heterozygous (AG). The G allele frequency was 56.7% and A allele frequency was 43.3%.
Model-based optimal action selection for Dyna-Q reverberation suppression cognitive sonar
Authors: Fu Yubin , Ma Xiaochuan , Feng Chao , Pei Xingxuan , Li Pengzhuo 
Published: November 2023

AbstractThe Doppler shift of low-speed targets is frequently disturbed by the reverberation Doppler spread clutter under the shallow sea. The clutter is generated by underwater scatterers, which increases the difficulty of Doppler estimation. To solve this problem, a reverberation target resolution function based on the Doppler spread clutter statistical model is proposed in this paper. Through the width of reverberation Doppler clutter, this function adjusts the waveform parameters by determining whether the target is discriminable. In addition, the reverberation Doppler spread clutter is time-spatial varying and affected by grazing angle, waves, wind speed, fish and other effects. Thus, the sonar waveform parameters need to be adjusted constantly. Therefore, this paper combines the cognitive sonar based on reinforcement learning with the reverberation target resolution function to evaluate different waveforms in different environments. Consequently, the sonar can adjust the waveform parameters in real-time and obtain the optimal waveform in different environments. Meanwhile, in this paper, the action selection strategy of Dyna-Q reinforcement learning is optimized, and the model-based maximum action selection Dyna-Q algorithm (Dyna-Q-Max-Action) is proposed. Compared with the traditional Dyna-Q and Q-learning algorithms, the proposed algorithm needs fewer episodes. Finally, numerical simulation verified the effectiveness of the proposed algorithm.
What is the carbon footprint of reverse osmosis in water treatment plants? A systematic review protocol
Authors: Abolli Samaneh , Ghordouei Milan Esfandiar , Bashardoust Parnia , Alimohammadi Mahmood 
Published: November 2023

Abstract
Background
“Carbon footprint” (CF) is a direct measure of greenhouse gas emissions caused by a defined activity and can demonstrate global warming effects. The emissions of Greenhouse gases (GHGs) in water projects start from the primary water sources, followed by transportation, construction, and operation phases in the final treatment plants. Due to their possible environmental impacts, the water treatment plants equipped with Reverse Osmosis (RO) units will be investigated for their carbon footprint.

Methods
The research question is “What is the carbon footprint of reverse osmosis in water treatment plants?”. The literature search in this study will be divided into two sequential sections; in the first section, the search will be limited to Scopus, Science Direct, EMBASE, and PubMed databases. The keywords of water, “water treatment plants”, “water purification”, desalination, “reverse osmosis”, RO, “carbon emission”, “carbon dioxide/CO2 emission”, “carbon footprint”, “Life Cycle Assessment” and, LCA will be used. The carbon footprint of RO will be expressed based on the direct and indirect effects based on RO capacity. In the second section, the internet and specialist search will be done, and the search will be updated. No date limitation will be considered, and the main search will be done in English. When the search is completed, the screening will be performed. After removing duplicates, the title and abstract will be examined. The full text will be read if the title and abstract are not helpful for decision-making. In addition, the bibliography and references will proceed after the full-text screening. The Collaboration for Environmental Evidence (CEE) Critical Appraisal Tool will be used for risk of bias checking and study validity assessment. After full-text evaluation, data will be collected and categorized by two authors. If there is enough data, meta-analysis will be performed.
Systematic review registration PROSPERO CRD42022327572.