bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of High Discharge Specific Capacity Zinc Ion Battery Cathode Materials by Regulating VO 2 with Rare Earth Ions
Authors: Chai Dianhong , Liu Juan , Zhao Xiaoyu , Li Haozhen , Xiao Pengbo , Yuan Qionghua , Li Xiaocheng C. 
Published: December 2023

Abstract

Vanadium oxides, as one of the cathode materials of great interest for aqueous zinc ion batteries (AZIBs), suffer from the disadvantages of low electrical conductivity, easy structural collapse, and poor cycling ability, so in this paper, the strategy of combining vanadium oxides with rare earth elements is used to improve their electrochemical properties. In this paper, a one-step hydrothermal method is proposed to prepare Ce-VO2 cathode material and use it as the cathode material for aqueous zinc ion batteries.The spherical morphology of Ce-VO2 has the advantages of large lattice spacing, structural stability, many active sites, and high specific discharge capacity.As the cathode material for aqueous zinc ion batteries, Ce-VO2 can discharge a high specific discharge capacity of 388 mAh g− 1 at 0.1 A g− 1. The electrode still has a specific capacity of 157 mAh g− 1 after 1000 cycles at 1 A g− 1. This work confirms that rare earth elements can be applied in the field of aqueous zinc ion batteries and provides new ideas for designing more advanced electrode materials.
Role of the Sirt6/Hmgb1 pathway in neuroinflammation of Sleep deprivation-induced depressed mice
Authors: Cao Dandan , Wei Dongyun , Wang Yuting , Yan Minhao , Su Shijie , Pan Huashan , Wang Qi 
Published: December 2023

Abstract
Many depressed patients exhibit sleep disorders, which in turn are a driver of the onset of depression. There is substantial evidence that neuroinflammation plays a key role in the pathophysiology and treatment of depression. Here, we investigated the mechanisms by which sleep deprivation (SD) induced anxiety-depressive-like behaviors in mice and the role of neuroinflammation in it. Adult male C57BL/6J mice were selected for the construction of a depression model by SD instrumentation. Five behavioral tests were used to evaluate the anxiety and depressive-like behaviors of the mice. H＆E staining and Nissl staining were utilized to detect cellular morphology and neuronal changes. Real-time quantitative fluorescence PCR (RT-qPCR) was carried out to regulate the mRNA levels of the clock gene, Silent information regulators 6 (Sirt6), High mobility group box-1 (Hmgb1), and pro-inflammatory factors. Western blot and immunofluorescence proved that SD increased the levels of clock genes and Sirt6/Hmgb1 pathway proteins. Our research showed that SD can be used as a reliable mouse model of depression. The pathological mechanism may be that SD regulated the Sirt6/Hmgb1 pathway and affected the transcription of clock genes, leading to inflammatory infiltration in the mPFC region of mice.
Structure and dynamics of the RF-amide QRFP receptor GPR103
Authors: Nureki Osamu , Iwama Alka , Akasaka  Hiroaki , Sano Fumiya , Oshima Hidetaka , Shihoya Wataru 
Published: December 2023

Abstract

Pyroglutamylated RF amide peptide (QRFP) is a type of peptide hormone with a C-terminal RF-amide motif. QRFP selectively activates class-A categorized GPCR, GPR103 to exert various physiological functions such as energy metabolism and appetite regulation. Here, we report the cryo-electron microscopy structure of the QRFP-GPR103-Gq complex at 3.3 Å resolution. Unlike class-A GPCR, QRFP adopts an extended structure baring no secondary structure, with its N-terminal and C-terminal sides recognized by extracellular and transmembrane domains, respectively, of GPR103. The C-terminal heptapeptide of QRFP penetrates into the orthosteric pocket to act in receptor activation. Particularly, the residues that recognize the RF-amide are highly conserved in the RF-amide receptors. Notably, the unique N-terminal helix-loop-helix of the receptor traps the N-terminal side of QRFP with the pendulum-like motion to guide QRFP into the ligand-binding pocket. This movement, reminiscent of class B1 GPCRs except for orientation and structure of the ligand, is critical for the high affinity binding and receptor specificity of QRFP. Structural comparisons with closely related receptors, including RY-amide peptide-recognizing GPCRs, revealed conserved and diversified peptide recognition mechanisms, providing profound insights into the biological significance of RF-amide peptides. This study not only advances our understanding of GPCR-ligand interactions, but also paves the way for the development of novel therapeutics targeting metabolic and appetite disorders and emergency medical care.
Optimization of Glow Discharge Cleaning for Enhanced Plasma Performance in ITER: A Study on Discharge Similarity and Electrode Configuration
Authors: Zhang Song , Duan Zemin , Miao Pengcheng , Si Xiaoliang 
Published: December 2023

Abstract
Glow discharge is characterized by its uniform cleaning ability and simplicity in system structure, and has been a standard method for wall conditioning and treatment in Tokamak devices, particularly during the maintenance phase and following atmospheric exposure of the vacuum chamber. This study presents a two-dimensional fluid model of glow discharge that incorporates temperature parameters. The model simulates discharge characteristics under two scaled-down scenarios, revealing that during the sub-glow and normal glow discharge stages, both systems exhibit similar distributions of electron and positive ion densities, satisfying the criteria for discharge similarity. Furthermore, the temperature differences induced by the discharge are found to significantly influence the spatially reduced electric fields. This variation in reduced field strength leads to distinct distributions of charged particles, which is identified as the primary cause for the deviation from similarity during abnormal glow discharge phases.
Seroprevalence and Risk Factors of Toxoplasma Gondii Infection in Cattle, Sheep and Goats in Katsina, State Nigeria
Authors: Orpin James Bemshima , Oyeyi Tinuke , Abdullahi Nura 
Published: December 2023

Abstract
Toxoplasmosis is still an important health problem in developing nations including Nigeria. Studies were taken in order to assess the Seroprevalence of Toxoplasma gondii infection in Cattle, Sheep and goats in Katsina State in order to provide valuable baseline information that will facilitate the design of an effective control strategy. A farmhouse based, cross-sectional seroprevalence study was carried out to establish the seroprevalence of toxoplasmosis in Cattle, Sheep and goats in Katsina State from August 2019 to July 2020 based on animal’ owners willingness. Laboratory techniques employed were separation of sera by centrifugation at 3200 RPM for 10 minutes and then the use of Rapid Diagnostic Toxo IgG Test kits for the detection of anti T. gondii antibodies IgG. Questionnaire survey was done in farmhouses visited to determine risk factors associated with T. gondii infection. Data was analysed using chi square, odds ratio, risk ratio and bivariate analysis for the risk factors. The seroprevalence of T. gondii infection in the domestic ruminants was found to be 17.57%. Strong associations were found amongst the sex, age, drinking habits of the animals, presence of cats on farms and house types (P˂0.05). The prevalence of female animals (17.97%) to the males (16.49%) was significant (P˂0.05) as well as the younger ruminants of less than one-year-old (37.37%) recording higher infection than the older ones (7.45%) (P˂0.05). Toxoplasmosis seropositivity was higher in the ruminants in the wet season than in the dry season, which showed significant difference (P˂0.05) in infection between the seasons. Based on the regions/zones, there was significant difference (P˂0.05) for seropositivity in the animals. From this result, it can be concluded that there was prevalence of T. gondii infection in the domestic ruminants in all the farmhouses visited, this warns on the public health safety problems. There is therefore the urgent need for the implementation of biosecurity measures, public awareness campaign for workers at farmhouses in Katsina State.
Smart stimulus-responsive mesoporous silicon combined with chemotherapy and photothermal therapy reverses tumor immunosuppressive microenvironment to enhances antitumor immunity
Authors: Chen Shuai , Huang Rui , Shen Feiyang , Wu Yijia , Lin Yao , Yang Xiaoyu , Shen Jianfeng , Fang Yan 
Published: December 2023

Abstract
Due to the tumor immunosuppressive microenvironment and potential systemic toxicity, chemotherapy often fails to trigger satisfactory anti-tumor results, so how to activate anti-tumor immunity to improve the therapeutic effect remains a challenging problem. Photothermal therapy (PTT) is an efficient method of inducing the tumor neoantigen release in situ, which offers potential for application in cancer immunotherapy. In this study, we constructed mesoporous silicon nanoparticles (MSNs) containing tetrasulfide bonds loaded with the traditional drug doxorubicin (DOX) inside and modified the outer layer with polydopamine (DOX/MSN-4S@PDA) for both in vivo and in vitro anti-tumor studies. Additionally, the mesoporous silicon core contains GSH-sensitive tetrasulfide bonds, which not only enhances the release of DOX but also generates hydrogen sulfide (H2S) which greatly improves the therapeutic effect of DOX. The polydopamine (PDA) in the outer layer provides the nanoparticles with acid sensitivity as well as a mild photothermal effect when exposed to near-infrared (NIR) light irradiation. Furthermore, the outermost layer is modified with hyaluronic acid (HA), allowing for targeted delivery to CD44-expressing tumor cells, further improving the accumulation of drugs at the tumor site and reducing toxic side effects. Results of our in vivo studies indicated that DOX/MSN@PDA-HA can reverse the immunosuppressive tumor microenvironment and improve the anti-tumor effect by triggering powerful immunogenic cell death (ICD) of tumor cells. Meanwhile, in vivo results showed that DOX/MSN@PDA-HA can significantly inhibit tumor metastasis to the lungs and liver. In summary, DOX/MSN@PDA-HA exhibits controlled release of therapeutic drugs, excellent biocompatibility, and significant tumor inhibition capabilities through synergistic chemical/photothermal combined therapy.
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
Authors: Zeng Chenxi , Yue Huihui , Wang Congjian , Ju Xuetao , Wang Tianlai , Fu Xiangning , Zhou Qing , Zhang Huilan , He Long , Yu Jun , Wang Yi 
Published: December 2023

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disorder for which effective treatments remain limited. Recent investigations revealed a potential link between altered glucose metabolism and the activation of fibroblasts, the key cells responsible for generating and depositing extracellular matrix proteins within the lung interstitium during IPF development.
Method
In this study, we aimed to investigate the potential therapeutic impact of albendazole on fibroblast to myofibroblast transition in IPF. We assess albendazole ‘s effectiveness in attenuating the activation of fibroblasts. We focused on elucidating the mechanism underlying albendazole's impact on TGF-β1-induced aerobic glycolysis in both lung tissues and fibroblasts obtained from patients with IPF and other lung fibrosis types. Furthermore, the antifibrotic effects of oral administration of albendazole were investigated in mouse models of pulmonary fibrosis induced by BLM or SiO2. Human precision-cut lung slices were employed to evaluate the impact of albendazole following TGF-β1 stimulation.
Result
In this work, we demonstrated that albendazole, a first-line broad-spectrum anthelmintic drug, effectively attenuated fibroblast to myofibroblast transition through alleviating TGF-β1-induced aerobic glycolysis dependent on the LRRN3/PFKFB3 signaling pathway. Additionally, LRRN3 expression was downregulated in both lung tissues and fibroblasts from patients with IPF and other types of lung fibrosis. Importantly, the levels of LRRN3 correlated with the progression of the disease. Notably, oral administration of albendazole exerted potent antifibrotic effects in mouse models of pulmonary fibrosis induced by BLM or SiO2, and in human precision-cut lung slices after TGF-β1 stimulation, as evidenced by improvements in lung morphology, reduced myofibroblast formation, and downregulation of α-SMA, collagen type 1 and FN expression in the lungs.
Conclusion
Our study implies that albendazole can act as a potent agonist of LRRN3 during fibroblast to myofibroblast differentiation and its oral administration shows potential as a viable therapeutic approach for managing IPF in clinical scenarios.
Noninvasive Evaluation of Myocardial Work in Hemodialysis Patients By Left Ventricular Pressure-Strain Loop Technique
Authors: Miao Yunxiang , Fan Lin , Zhou Bingyuan , Chen Fengling , Liao Yuping 
Published: December 2023

Abstract
Background Noninvasive left ventricular pressure-strain loop was used to evaluate the changes of myocardial work index in maintenance hemodialysis (MHD) patients.Methods We included 62 patients undergoing regular hemodialysis (HD) at the First Affiliated Hospital of Soochow University from July 2020 to October 2022. Left ventricular ejection fraction (LVEF) was measured by Simpson biplane method. Pulsed Doppler was used to calculate cardiac output (CO). Left ventricular longitudinal strain was obtained by two-dimensional speckle tracking imaging (2D-STI). Systolic blood pressure and diastolic blood pressure were input to obtain global work index (GWI), global constructive work (GCW), global wasted work (GEE) and global work efficiency (GWE). The differences of echocardiographic parameters before and after HD treatment were compared.Results After HD treatment, the size of cardiac chambers, LVEF and cardiac output decreased compared with those pre-HD (P < 0.05); Heart rate was faster than pre-HD (P < 0.05). Left ventricular diastolic function parameters (E-wave, A-wave, Septal e', Lateral e', E/e’ and PASP) were lower than pre-HD; GLS, GWI and GCW decreased after HD treatment (P < 0.05); There were no significant changes in GWW and GWE between HD sessions (P > 0.05).Conclusion Hemodialysis removed excessive fluids, the heart chambers became smaller. LVEF and CO declined, but remained within normal ranges. Left ventricular diastolic function was improved compared with pre-HD. PSL technique can effectively evaluate left ventricular myocardial work, and can provide a new approach for evaluating volume load and left ventricular myocardial function in HD patients. It is further verified that the myocardial work parameters have good repeatability.
Gene expression in metastatic breast cancer – patterns with prognostic potential in primary tumors and metastatic tissue
Authors: Tutzauer Julia , Larsson Anna-Maria , Aaltonen Kristina , Bergenfelz Caroline , Bendahl Pär-Ola , Rydén Lisa 
Published: December 2023

Abstract

Background
Metastatic breast cancer (MBC) is the main cause of breast cancer-related death. The outcome of MBC varies, and there is a lack of biomarkers to aid in prognostication. The primary aim of this study was to evaluate the prognostic value of gene expression (GEX) signatures in the primary tumor (PT) and distant metastasis (DM) for progression-free survival (PFS) and overall survival (OS). The secondary aim was to describe GEX changes through MBC evolution and to identify MBC subtypes.
Methods
RNA was extracted from the PT, lymph node metastases (LNM), and DM from MBC patients in a prospective observational study (n = 142; CTC-MBC NCT01322893) and was subjected to GEX analysis retrospectively using the NanoString Breast Cancer 360™ panel. 31 continuous GEX variables in DMs and PTs were analyzed for PFS and OS by Cox regression analysis and Kaplan-Meier estimates. Multivariable Cox regressions were adjusted for number of DM sites and CTCs, visceral metastasis, ECOG status, age at MBC diagnosis and, in additional analyses, PAM50 subtype. Differential GEX analyses and Euclidean distances were used to describe subgroup differences and visualize within-patient heterogeneity.
Results
Compared to DM GEX, GEX of the PT was at least equally useful for prognosticating MBC outcome. The strongest marker for a favorable PFS, both when expressed in the PT and the DM was AR, even after adjustment for prognostic markers including PAM50. GEX signatures related to hormone responsiveness, including ESR1, FOXA1, PGR, and AR were favorable prognostic markers, and the p53 signature was unfavorable for PFS when expressed in PT or DM. The previously published PAM50MET signature was prognostic for both PFS and OS. We established five distinct DM GEX profiles where two associated with liver and bone metastases, respectively. Finally, we identified four DM GEX profiles able to identify MBCs with poor OS in this cohort.
Conclusion
GEX of both DM and PT are useful in MBC prognostication. GEX of AR adds prognostic information for MBC. Our descriptive analyses illuminate the biological differences between MBCs in relation to outcome and metastatic site.
Proprioceptive Training Methods (PTM) in Female Soccer Players – A Systematic Review
Authors: Stanković Mima , Čaprić Ilma , Katanić Borko , Špirtović Omer , Maljanović Džejla , Nailovic Hamza , Mukovic Iso , Jelaska Igor , Trajković Nebojša 
Published: December 2023

Abstract

Background
Although previous studies have reported that proprioceptive training methods (PTM) have positive effects, there are a relatively small number of studies on the impact of PTM in women's soccer, and there is a need to systematize the given results. In this regard, this systematic review aimed to investigate the effect of proprioceptive training methods in female soccer players.
Methods
The studies' search and analysis were done according to the PRISMA guidelines. An electronic databases search (Google Scholar, PubMed Cochrane, ProQuest, and Research Gate), yielded 175 relevant studies conducted from 2000 to 2023.
Results
A total of 7 studies were included in the quantitative synthesis. Based on the analysis of previous research and detailed discussion, the main findings of the study resulted in the improvement of strength and muscle imbalance and the prevention and reduction of lower extremity injuries in female soccer players. PTM also improved agility, speed and accuracy in female soccer players.
Conclusion
The obtained results indicate the necessity of implementing proprioceptive training in female soccer training programs, in order to influence the prevention and reduction of injuries and improve balance and proprioceptive ability, and improve body control.
Water Quality Influences Cerrado Odonata Larval Assemblages
Authors: Melo Gabrielly Silva , Ferreira Victor Rennan Santos , Juen Leandro , Batista Joana Darc , Giehl Nubia França da Silva , Cabette Helena Soares Ramos , de Resende Bethânia Oliveira 
Published: December 2023

Abstract
Changes in water quality and stream habitats can significantly impact Odonata larvae dynamics as a result of their specific ecological requirements. This study investigated the effects of water quality and microhabitats on the structure of Odonata larval communities. During the same period, substrate types, water variables, and Odonata larvae were sampled. Our findings reveal that substrate type had no impact on community structure. However, the presence of ammonia and oxygen levels, among other water quality, influenced the abundance of Odonata larvae. While Odonata organisms are sensitive to the local environment, the intermittent flow of the creek and seasonal changes may be responsible for the lack of substrate influence on the Odonata community. Abiotic factors also play a critical role since Odonata larvae have limits to which they can tolerate. Variations in these factors can have a profound impact on the persistence and survival of the larvae. Additionally, the larvae's physiological responses, such as respiration, are influenced by these factors. Zygoptera larvae, which have branchial respiration, necessitate a water environment with low temperatures and high levels of dissolved oxygen. Therefore, the abiotic variables of the stream significantly affect the Odonata larvae community. Incorporating natural environmental changes and variations into monitoring and conservation programs is essential. By doing so, we can enhance our understanding of biodiversity and its distribution patterns, leading to more effective preservation efforts.
Exploring Patient Perspectives on EQ-5D-5L Data Visualization within an Individualized Decision Aid for Total Knee Arthroplasty (TKA) in Alberta, Canada
Authors: Johnson Jeffrey , Itiola Ademola , Rahman Shakib , Smith Christopher , Soprovich Allison , Wozniak Lisa , Marshall Deborah 
Published: December 2023

Abstract
Background
Decision aids can help patients set realistic expectations. In this study, we explored alternative presentations to visualise patient-reported outcomes (EQ-5D-5L) data within an online, individualized patient decision aid for total knee arthroplasty (TKA) to enhance usability prior to implementation into routine clinical practice.
Methods
We used data visualization techniques to modify the presentation of EQ-5D-5L outcomes data within the decision aid. The EQ-5D-5L data was divided into two parts allowing patients to compare themselves to similar individuals (1) pre-surgery and (2) 1-year post-surgery. We created 2 versions for each part and sought patient feedback on comprehension, usefulness, and visual appeal. Patients from an urban orthopedic clinic were recruited and their ratings and comments were recorded using a researcher-administered checklist. Data were managed using Microsoft Excel, R version 3.6.1 and ATLAS.ti V8 and analyzed using descriptive statistics and directed content analysis.
Results
A total of 24 and 25 patients participated in Parts 1 and 2, respectively. Overall, there was a slight preference for Version 1 in Part 1 (58.3%) and Version 2 in Part 2 (64%). Most participants demonstrated adequate comprehension for all versions (range 50–72%) and commented that the instructions were clear. While 50–60% of participants rated the content as useful, including knowing the possible outcomes of surgery, some participants found the information interesting only, were unsure how to use the information, or did not find it useful because they had already decided on a treatment. Participants rated visual appeal for all versions favorably but suggested improvements for readability, mainly larger font and image sizes and enhanced contrast between elements.
Conclusions
Based on the results, we will produce an enhanced presentation of EQ-5D-5L data within the decision aid. These improvements, along with further usability testing of the entire decision aid, will be made before implementation of the decision aid in routine clinical practice. Our results on patients’ perspectives on the presentation of EQ-5D-5L data to support decision making for TKA treatments contributes to the knowledge on EQ-5D-5L applications within healthcare systems for clinical care.