bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who Needs to Tell the Truth? – Epistemic Injustice and Truth and Reconciliation Commissions for Minorities in Non-Transitional Societies
Authors: Reibold Kerstin 
Published: January 2024

Abstract
Truth and Reconciliation Commissions (TRCs) have become a widely used tool to reconcile societies in the aftermath of widespread injustice or social and political conflict in a state. This article focuses on TRCs that take place in non-transitional societies in which the political and social structures, institutions, and power relations have largely remained in place since the time of injustice. Furthermore, it will focus on one particular injustice that TRCs try to address through the practice of truth-telling, namely the eradication of epistemic injustice. The article takes the Canadian and Norwegian TRCs as two examples to show that under conditions of enduring injustice, willful ignorance of the majority, and power inequality, TRCs might create a double bind for victims which makes them choose between epistemic exploitation and continued injustices based on the majority's ignorance. The article argues that the set-up and accompanying measures of TRCs are of the utmost importance if TRCs in non-transitional societies are to overcome epistemic injustice, instead of creating new relations of exploitation.
Toward the Unified Theory of SAID‐Linked Subauroral Arcs
Authors: Mishin Evgeny V. , Streltsov Anatoly V. 
Published: January 2024

AbstractWe present a unified approach to subauroral arcs within intense subauroral ion drifts (SAID), which explains the observed transition of a precursor Stable Auroral Red (SAR) arc into Strong Thermal Emission Velocity Enhancement (STEVE). This approach is based on the short‐circuiting concept of fasttime SAID as an integral part of a magnetospheric voltage generator between the innermost boundaries of the freshly injected plasma sheet electrons and ring current ions. Here, enhanced plasma turbulence rapidly heats the bulk plasma and accelerates suprathermal non‐Maxwellian “tails.” Heat and suprathermal electron transport rapidly elevate the ionospheric electron temperature—the source of a bright SAR arc. Through a substorm, the density altitude profile within the evolving ionospheric SAID channel transforms into a “fresh” F‐region trough with the E‐region valley. The ionospheric feedback instability within the depleted‐density SAID channel generates small‐scale, field‐aligned currents with parallel electric fields sufficient to produce the suprathermal electron population, exciting the STEVE and Picket Fence emissions. This approach also explains the inner electromagnetic structure of intense SAID, which is consistent with fine optical structures in STEVE and Picket Fence.
Systematic review of microplastics and nanoplastics in indoor and outdoor air: identifying a framework and data needs for quantifying human inhalation exposures
Authors: Eberhard Tiffany , Casillas Gaston , Zarus Gregory M. , Barr Dana Boyd 
Published: January 2024

Abstract
Background
Humans are likely exposed to microplastics (MPs) in a variety of places including indoor and outdoor air. Research to better understand how exposure to MPs correlates to health is growing. To fully understand the possible impacts of MPs on human health, it is necessary to quantify MP exposure and identify what critical data gaps exist.

Objectives
The current paper provides a human exposure assessment of microplastics in the air using systematically reviewed literature that provided concentration of MPs in air as well as doses used in toxicology studies to calculate inhalation exposure dose.

Methods
All published peer-reviewed journal articles, non-published papers, and grey literature that focused on micro- or nano-plastics in indoor and outdoor air were systematically searched using PRISMA guidelines. Literature that defined specific concentrations and size of MPs in air or exposed to human lung cells, animals, or humans with measurable health impacts were included in data extraction. Inhalational exposures were calculated for different age groups using published MP concentrations from the included literature using exposure dose equations and values from U.S. ATSDR and EPA.

Results
Calculated mean indoor inhalational exposures from passive sampling methods were higher than those calculated from active sampling methods. When comparing indoor and outdoor sampling, calculated inhalation exposures from indoor samples were greater than those from outdoor samples. Inhalation exposures of MPs differed between age groups with infants having the highest calculated dose values for all locations followed by preschool age children, middle-school aged children, pregnant women, adolescents, and non-pregnant adults. MP doses used in toxicology studies produced higher calculated mean inhalational exposures than those from environmental samples.

Impact
This study is the first known systematic review of inhalational MP exposure from indoor and outdoor air. It also provides inhalational exposures calculated from previously published environmental samples of MPs as well as from toxicology studies.
Reconstructing individual-level exposures in cohort analyses of environmental risks: an example with the UK Biobank
Authors: Vanoli Jacopo , Mistry Malcolm N. , De La Cruz Libardi Arturo , Masselot Pierre , Schneider Rochelle , Ng Chris Fook Sheng , Madaniyazi Lina , Gasparrini Antonio 
Published: January 2024

Abstract
Recent developments in linkage procedures and exposure modelling offer great prospects for cohort analyses on the health risks of environmental factors. However, assigning individual-level exposures to large population-based cohorts poses methodological and practical problems. In this contribution, we illustrate a linkage framework to reconstruct environmental exposures for individual-level epidemiological analyses, discussing methodological and practical issues such as residential mobility and privacy concerns. The framework outlined here requires the availability of individual residential histories with related time periods, as well as high-resolution spatio-temporal maps of environmental exposures. The linkage process is carried out in three steps: (1) spatial alignment of the exposure maps and residential locations to extract address-specific exposure series; (2) reconstruction of individual-level exposure histories accounting for residential changes during the follow-up; (3) flexible definition of exposure summaries consistent with alternative research questions and epidemiological designs. The procedure is exemplified by the linkage and processing of daily averages of air pollution for the UK Biobank cohort using gridded spatio-temporal maps across Great Britain. This results in the extraction of exposure summaries suitable for epidemiological analyses of both short and long-term risk associations and, in general, for the investigation of temporal dependencies. The linkage framework presented here is generally applicable to multiple environmental stressors and can be extended beyond the reconstruction of residential exposures.

Impact
This contribution describes a linkage framework to assign individual-level environmental exposures to population-based cohorts using high-resolution spatio-temporal exposure. The framework can be used to address current limitations of exposure assessment for the analysis of health risks associated with environmental stressors. The linkage of detailed exposure information at the individual level offers the opportunity to define flexible exposure summaries tailored to specific study designs and research questions. The application of the framework is exemplified by the linkage of fine particulate matter (PM2.5) exposures to the UK Biobank cohort.
Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma
Authors: Fischer Luise , Grieb Nora , Born Patrick , Weiss Ronald , Seiffert Sabine , Boldt Andreas , Fricke Stephan , Franz Paul , Heyn Simone , Kubasch Anne Sophie , Baber Ronny , Weidner Heike , Wang Song Yau , Bach Enrica , Hoffmann Sandra , Ussmann Jule , Kirchberg Janine , Hell Saskia , Schwind Sebastian , Metzeler Klaus H. , Herling Marco , Jentzsch Madlen , Franke Georg-Nikolaus , Sack Ulrich , Reiche Kristin , Köhl Ulrike , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian 
Published: January 2024

AbstractB-cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells revolutionized the treatment of relapsed/refractory multiple myeloma (RRMM). However, data on cellular (CAR) T cell dynamics and the association with response, resistance or the occurrence of cytokine release syndrome (CRS) are limited. Therefore, we performed a comprehensive flow cytometry analysis of 27 RRMM patients treated with Idecabtagene vicleucel (Ide-cel) to assess the expansion capacity, persistence and effects on bystander cells of BCMA-targeting CAR T cells. Additionally, we addressed side effects, like cytokine release syndrome (CRS) and cytopenia. Our results show that in vivo expansion of CD8+ CAR T cells is correlated to response, however persistence is not essential for durable remission in RRMM patients. In addition, our data provide evidence, that an increased fraction of CD8+ T cells at day of leukapheresis in combination with successful lymphodepletion positively influence the outcome. We show that patients at risk for higher-grade CRS can be identified already prior to lymphodepletion. Our extensive characterization contributes to a better understanding of the dynamics and effects of BCMA-targeting CAR T cells, in order to predict the response of individual patients as well as side effects, which can be counteracted at an early stage or even prevented.
Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential
Authors: Zhang Chunye , Stelloo Ellen , Barrans Sharon , Cucco Francesco , Jiang Dan , Tzioni Maria-Myrsini , Chen Zi , Li Yan , Swennenhuis Joost F. , Makker Jasmine , Rásó-Barnett Lívia , Liu Hongxiang , El-Daly Hesham , Soilleux Elizabeth , Shah Nimish , Nagumantry Sateesh Kumar , Kyaw Maw , Prahladan Mahesh Panatt , Tooze Reuben , Westhead David R. , Feitsma Harma , Davies Andrew J. , Burton Catherine , Johnson Peter W. M. , Du Ming-Qing 
Published: January 2024

AbstractMYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit (TH). DLBCL-MYC/BCL2-DH/TH are largely germinal centre B-cell like subtype, but show variable clinical outcome, with IG::MYC fusion significantly associated with inferior survival. While DLBCL-MYC/BCL6-DH are variable in their cell-of-origin subtypes and clinical outcome. Intriguingly, only 40-50% of DLBCL with MYC translocation show high MYC protein expression (>70%). We studied 186 DLBCLs with MYC translocation including 32 MYC/BCL2/BCL6-TH, 75 MYC/BCL2-DH and 26 MYC/BCL6-DH. FISH revealed a MYC/BCL6 fusion in 59% of DLBCL-MYC/BCL2/BCL6-TH and 27% of DLBCL-MYC/BCL6-DH. Targeted NGS showed a similar mutation profile and LymphGen genetic subtype between DLBCL-MYC/BCL2/BCL6-TH and DLBCL-MYC/BCL2-DH, but variable LymphGen subtypes among DLBCL-MYC/BCL6-DH. MYC protein expression is uniformly high in DLBCL with IG::MYC, but variable in those with non-IG::MYC including MYC/BCL6-fusion. Translocation breakpoint analyses of 8 cases by TLC-based NGS showed no obvious genomic configuration that enables MYC transactivation in 3 of the 4 cases with non-IG::MYC, while a typical promoter substitution or IGH super enhancer juxtaposition in the remaining cases. The findings potentially explain variable MYC expression in DLBCL with MYC translocation, and also bear practical implications in its routine assessment.
Phase transitions in 2D multistable mechanical metamaterials via collisions of soliton-like pulses
Authors: Jiao Weijian , Shu Hang , Tournat Vincent , Yasuda Hiromi , Raney Jordan R. 
Published: January 2024

AbstractIn recent years, mechanical metamaterials have been developed that support the propagation of an intriguing variety of nonlinear waves, including transition waves and vector solitons (solitons with coupling between multiple degrees of freedom). Here we report observations of phase transitions in 2D multistable mechanical metamaterials that are initiated by collisions of soliton-like pulses in the metamaterial. Analogous to first-order phase transitions in crystalline solids, we observe that the multistable metamaterials support phase transitions if the new phase meets or exceeds a critical nucleus size. If this criterion is met, the new phase subsequently propagates in the form of transition waves, converting the rest of the metamaterial to the new phase. More interestingly, we numerically show, using an experimentally validated model, that the critical nucleus can be formed via collisions of soliton-like pulses. Moreover, the rich direction-dependent behavior of the nonlinear pulses enables control of the location of nucleation and the spatio-temporal shape of the growing phase.
Moving event detection from LiDAR point streams
Authors: Wu Huajie , Li Yihang , Xu Wei , Kong Fanze , Zhang Fu 
Published: January 2024

AbstractIn dynamic environments, robots require instantaneous detection of moving events with microseconds of latency. This task, known as moving event detection, is typically achieved using event cameras. While light detection and ranging (LiDAR) sensors are essential for robots due to their dense and accurate depth measurements, their use in event detection has not been thoroughly explored. Current approaches involve accumulating LiDAR points into frames and detecting object-level motions, resulting in a latency of tens to hundreds of milliseconds. We present a different approach called M-detector, which determines if a point is moving immediately after its arrival, resulting in a point-by-point detection with a latency of just several microseconds. M-detector is designed based on occlusion principles and can be used in different environments with various types of LiDAR sensors. Our experiments demonstrate the effectiveness of M-detector on various datasets and applications, showcasing its superior accuracy, computational efficiency, detection latency, and generalization ability.
Remotely sensing potential climate change tipping points across scales
Authors: Lenton Timothy M. , Abrams Jesse F. , Bartsch Annett , Bathiany Sebastian , Boulton Chris A. , Buxton Joshua E. , Conversi Alessandra , Cunliffe Andrew M. , Hebden Sophie , Lavergne Thomas , Poulter Benjamin , Shepherd Andrew , Smith Taylor , Swingedouw Didier , Winkelmann Ricarda , Boers Niklas 
Published: January 2024

AbstractPotential climate tipping points pose a growing risk for societies, and policy is calling for improved anticipation of them. Satellite remote sensing can play a unique role in identifying and anticipating tipping phenomena across scales. Where satellite records are too short for temporal early warning of tipping points, complementary spatial indicators can leverage the exceptional spatial-temporal coverage of remotely sensed data to detect changing resilience of vulnerable systems. Combining Earth observation with Earth system models can improve process-based understanding of tipping points, their interactions, and potential tipping cascades. Such fine-resolution sensing can support climate tipping point risk management across scales.
Mechanism of anion exchange and small-molecule inhibition of pendrin
Authors: Wang Lie , Hoang Anthony , Gil-Iturbe Eva , Laganowsky Arthur , Quick Matthias , Zhou Ming 
Published: January 2024

AbstractPendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO3−) exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the kidney, lung, and cochlea. Pendrin also exports iodide (I−) in the thyroid gland. Pendrin mutations in humans lead to Pendred syndrome, causing hearing loss and goiter. Inhibition of pendrin is a validated approach for attenuating airway hyperresponsiveness in asthma and for treating hypertension. However, the mechanism of anion exchange and its inhibition by drugs remains poorly understood. We applied cryo-electron microscopy to determine structures of pendrin from Sus scrofa in the presence of either Cl−, I−, HCO3− or in the apo-state. The structures reveal two anion-binding sites in each protomer, and functional analyses show both sites are involved in anion exchange. The structures also show interactions between the Sulfate Transporter and Anti-Sigma factor antagonist (STAS) and transmembrane domains, and mutational studies suggest a regulatory role. We also determine the structure of pendrin in a complex with niflumic acid (NFA), which uncovers a mechanism of inhibition by competing with anion binding and impeding the structural changes necessary for anion exchange. These results reveal directions for understanding the mechanisms of anion selectivity and exchange and their regulations by the STAS domain. This work also establishes a foundation for analyzing the pathophysiology of mutations associated with Pendred syndrome.
Unfamiliarity generates costly aggression in interspecific avian dominance hierarchies
Authors: Leighton Gavin M. , Drury Jonathan P. , Small Jay , Miller Eliot T. 
Published: January 2024

AbstractDominance hierarchies often form between species, especially at common feeding locations. Yet, relative to work focused on the factors that maintain stable dominance hierarchies within species, large-scale analyses of interspecific dominance hierarchies have been comparatively rare. Given that interspecific behavioral interference mediates access to resources, these dominance hierarchies likely play an important and understudied role in community assembly and behavioral evolution. To test alternative hypotheses about the formation and maintenance of interspecific dominance hierarchies, we employ an large, participatory science generated dataset of displacements observed at feeders in North America in the non-breeding season. Consistent with the hypothesis that agonistic interference can be an adaptive response to exploitative competition, we find that species with similar niches are more likely to engage in costly aggression over resources. Among interacting species, we find broad support for the hypothesis that familiarity (measured as fine-scale habitat overlap) predicts adherence to the structure of the dominance hierarchy and reduces aggression between species. Our findings suggest that the previously documented agonistic hierarchy in North American birds emerges from species-level adaptations and learned behaviors that result in the avoidance of costly aggression.
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats
Authors: Gao Cheng , Wang Qingfu , Ding Yuanfu , Kwong Cheryl H. T. , Liu Jinwei , Xie Beibei , Wei Jianwen , Lee Simon M. Y. , Mok Greta S. P. , Wang Ruibing 
Published: January 2024

AbstractMembrane-camouflaged nanomedicines often suffer from reduced efficacy caused by membrane protein disintegration and spatial disorder caused by separation and reassembly of membrane fragments during the coating process. Here we show that intracellularly gelated macrophages (GMs) preserve cell membrane structures, including protein content, integration and fluidity, as well as the membrane lipid order. Consequently, in our testing GMs act as cellular sponges to efficiently neutralize various inflammatory cytokines via receptor-ligand interactions, and serve as immune cell-like carriers to selectively bind inflammatory cells in culture medium, even under a flow condition. In a rat model of collagen-induced arthritis, GMs alleviate the joint injury, and suppress the overall arthritis severity. Upon intravenous injection, GMs efficiently accumulate in the inflammatory lungs of acute pneumonia mice for anti-inflammatory therapy. Conveniently, GMs are amenable to lyophilization and can be stored at ambient temperatures for at least 1 month without loss of integrity and bio-activity. This intracellular gelation technology provides a universal platform for targeted inflammation neutralization treatment.
Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension
Authors: Ulrich Anna , Wu Yukyee , Draisma Harmen , Wharton John , Swietlik Emilia M. , Cebola Inês , Vasilaki Eleni , Balkhiyarova Zhanna , Jarvelin Marjo-Riitta , Auvinen Juha , Herzig Karl-Heinz , Coghlan J. Gerry , Lordan James , Church Colin , Howard Luke S. , Pepke-Zaba Joanna , Toshner Mark , Wort Stephen J. , Kiely David G. , Condliffe Robin , Lawrie Allan , Gräf Stefan , Morrell Nicholas W. , Wilkins Martin R. , Prokopenko Inga , Rhodes Christopher J. 
Published: January 2024

AbstractPulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association with PAH in 429 individuals with PAH and 1226 controls. Three loci, at Cathepsin Z (CTSZ, cg04917472), Conserved oligomeric Golgi complex 6 (COG6, cg27396197), and Zinc Finger Protein 678 (ZNF678, cg03144189), reached epigenome-wide significance (p < 10−7) and are hypermethylated in PAH, including in individuals with PAH at 1-year follow-up. Of 16 established PAH genes, only cg10976975 in BMP10 shows hypermethylation in PAH. Hypermethylation at CTSZ is associated with decreased blood cathepsin Z mRNA levels. Knockdown of CTSZ expression in human pulmonary artery endothelial cells increases caspase-3/7 activity (p < 10−4). DNA methylation profiles are altered in PAH, exemplified by the pulmonary endothelial function modifier CTSZ, encoding protease cathepsin Z.
Donor-acceptor pairs in wide-bandgap semiconductors for quantum technology applications
Authors: Bilgin Anil , Hammock Ian N. , Estes Jeremy , Jin Yu , Bernien Hannes , High Alexander A. , Galli Giulia 
Published: January 2024

AbstractWe propose a quantum science platform utilizing the dipole-dipole coupling between donor-acceptor pairs (DAPs) in wide bandgap semiconductors to realize optically controllable, long-range interactions between defects in the solid state. We carry out calculations based on density functional theory (DFT) to investigate the electronic structure and interactions of DAPs formed by various substitutional point-defects in diamond and silicon carbide (SiC). We determine the most stable charge states and evaluate zero phonon lines using constrained DFT and compare our results with those of simple donor-acceptor pair (DAP) models. We show that polarization differences between ground and excited states lead to unusually large electric dipole moments for several DAPs in diamond and SiC. We predict photoluminescence spectra for selected substitutional atoms and show that while B-N pairs in diamond are challenging to control due to their large electron-phonon coupling, DAPs in SiC, especially Al-N pairs, are suitable candidates to realize long-range optically controllable interactions.