bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of sucrose and 6-benzylaminopurine on shoot propagation and vitrification in Aronia melanocarpa (black chokeberry)
Authors: Bayhan Nida , Yücesan Buhara 
Published: January 2024

AbstractVitrification is one of the most significant issues encountered in plant tissue culture applications. It diminishes the quality of in vitro plants, causing their leaves and stems to appear watery and translucent, and it may impede the success of the acclimatization step. In this respect, this study investigates the impact of sucrose and 6-Benzylaminopurine (BAP) concentrations on shoot regeneration and vitrification development in Aronia melanocarpa, known for its high antioxidant content and health benefits. Initially, the presence of BAP, in combination with varying sucrose concentrations, leads to a substantial increase in shoot number, and the largest number (7 shoots per nodal explant) was observed in the Murashige and Skoog (MS) medium containing 3% sucrose and 5.0 mg/L BAP. Furthermore, sucrose concentration plays a crucial role in shoot growth, with higher concentrations promoting more extensive shoot development. However, when 3% sucrose was combined with higher BAP (from 1.0- to 5.0 mg/L), an increased incidence of vitrification was observed over time. Interestingly, lower sucrose concentrations (1% or 2%) combined with 0.5 mg/L or 2.5 mg/L BAP initially delayed vitrification but eventually led to its occurrence. Microscopic analysis of leaf samples with varying levels of vitrification indicates significant differences in the density of stomata, further confirming the detrimental impact of vitrification on cellular structures and physiological processes. The recovery of vitrified plants was evaluated using different growth media combinations. The absence of BAP in the medium led to higher recovery percentages (min 96%) without necrosis, while the addition of 0.5 mg/L BAP promoted shoot growth but potentially inhibited root development. It has been found that media with 1 mg/L BAP and either 10 g/L or 20 g/L sucrose, as well as media with 30 g/L sucrose and 0.5 mg/L BAP, are the most suitable for efficient shoot regeneration with minimal vitrification risk. However, increasing BAP levels for faster shoot regeneration also raises the risk of vitrification. During acclimatization, vitrified plants exhibited stunted shoot growth, shorter and narrower leaves, reduced root numbers and lengths, and decreased survival rates, particularly under lower humidity conditions. The cultivation period required for the recovery of the crop was determined to be 6 weeks under greenhouse conditions for a sustainable plant propagation.
Optimization of Process Parameters Affecting Glycoalkaloids in Potato Chips Using the Taguchi Method
Authors: Koyuncu Dilek , Duran Ayhan 
Published: January 2024

AbstractThis study presents the experimental and statistical examination of different process applications in the production process of the glycoalkaloid level in potato chips to which consumers are exposed. In the first stage, slice washing temperature (swt), frying temperature (ftemp) and frying time (ft) were determined as factors that could affect the glycoalkaloid level. Considering industrial applications, three different slice washing temperatures (25, 55 and 85 °C), frying temperatures (180, 185 and 190 °C) and frying times (165, 185 and 205 s) were evaluated for the study. The L9 orthogonal array of the Taguchi method, which has been successfully applied in the analysis of multiple parameters, was used as the experimental design. Examining the S/N (signal/noise) ratios, the optimum process parameters for minimum content of α-solanine (As) were obtained as 25 °C swt, 190 °C ftemp and 165 s ft. The optimum process parameters were determined for minimum content of α-chaconine (Ac) as 55 °C swt, 190 °C ftemp and 165 s ft. In the analysis results, as swt decreased, ftemp increased, and ft was shortened; the glycoalkaloid ratio in the chips decreased. Analysis of variance results showed the most effective process parameter was the frying time for α-solanine and α-chaconine with 68.2% and 76.5%, respectively. Then comes ftemp with an effectiveness rate of 17.35% and 16.77%. In addition, the regression model developed to estimate the output parameters (As and Ac) yielded successful results with high determination coefficients (R2) of 90.6% and 92.5%.
Bariatric Surgery and Weight Gain: Bibliometric Analysis
Authors: Seckin Damla , Cebeci Fatma 
Published: January 2024

Abstract
Purpose
Bariatric surgery is the most successful method for weight loss; however, weight regain may occur in the long term. It depends on eating habits and self-management. The study aimed to conduct a bibliometric analysis on bariatric surgery and weight gain and to determine the content and trends in the literature.

Materials and Methods
The scan was performed using the keywords “bariatric surgery” and “weight gain” in the Web of Science database. The years of publications and citations, the distribution of publications according to journals, research areas, and countries, co-authorship, co-occurrence, and co-citation were analyzed. The VOSviewer program was used for the analysis. Grey literature, books, and book sections were not included.

Results
A total of 988 articles were included. The results showed that the most published and cited journal was Obesity Surgery, and the most published country was the USA with 313 publications. The most commonly used keywords were “bariatric surgery,” “obesity,” and “weight regain.” Harvard University was the most publishing institution with 50 publications. The most published year was 2022 since 1993 (n:118).

Conclusion
In the study, current publications and research trends related to bariatric surgery and weight gain were analyzed through bibliometric analysis. It was concluded that weight regain after bariatric surgery should be focused on since it adversely affects the life of individuals, reduces the probability of success of surgical treatment, and imposes additional burdens on the healthcare system.

Graphical Abstract
Electronic sanitary database: a new potential tool to identify occult chronic liver disease in general population
Authors: Cagnin Silvia , Martini Andrea , Donato Daniele , Angeli Paolo , Pontisso Patrizia 
Published: January 2024

AbstractChronic liver disease (CLD) is a leading global cause of mortality, morbidity, and healthcare resource utilization. However, the burden of CLD is underestimated because the course of the disease is often asymptomatic until clinical decompensation and the development of life-threatening complications. In this study, we assessed the use of available blood tests from electronic medical records for identifying individuals with undiagnosed CLD in the general population. We analyzed a total of 202,529 blood tests obtained from 99,848 adults recorded in the Electronic Health Records of the Padova Teaching Hospital. Transaminases levels > 1.5 times the normal value indicated occult CLD, while platelet counts < 120,000/μL identified occult cirrhosis. We characterized patients using Italian Medical Exemptions (IME), excluding oncologic cases. Overt and occult cirrhosis prevalence was 1% and 4.18%, respectively, while overt and occult CLD affected 2.85% and 4.61% of the population. The epidemiology of patients with overt and occult cirrhosis was similar but significantly different from that of the controls. Among subjects aged 60–70 years, working disability was twofold higher in those with occult cirrhosis compared to those with overt cirrhosis. Occult CLD and cirrhosis had higher prevalence rates than diagnosed cases in the general population. Electronic medical record data may serve as a valuable tool for CLD identification, potentially reducing cirrhosis development and clinical decompensation. This, in turn, may lead to a decrease in the economic impact on the healthcare system.
Optimal semiclassical spectral asymptotics for differential operators with non-smooth coefficients
Authors: Mikkelsen Søren 
Published: January 2024

AbstractWe consider differential operators defined as Friedrichs extensions of quadratic forms with non-smooth coefficients. We prove a two-term optimal asymptotic for the Riesz means of these operators and thereby also reprove an optimal Weyl law under certain regularity conditions. The methods used are then extended to consider more general admissible operators perturbed by a rough differential operator and to obtain optimal spectral asymptotics again under certain regularity conditions. For the Weyl law, we assume that the coefficients are differentiable with Hölder continuous derivatives, while for the Riesz means we assume that the coefficients are twice differentiable with Hölder continuous derivatives.
The Use of Artificial Intelligence in Writing Scientific Review Articles
Authors: Kacena Melissa A. , Plotkin Lilian I. , Fehrenbacher Jill C. 
Published: January 2024

Abstract
Purpose of Review
With the recent explosion in the use of artificial intelligence (AI) and specifically ChatGPT, we sought to determine whether ChatGPT could be used to assist in writing credible, peer-reviewed, scientific review articles. We also sought to assess, in a scientific study, the advantages and limitations of using ChatGPT for this purpose. To accomplish this, 3 topics of importance in musculoskeletal research were selected: (1) the intersection of Alzheimer’s disease and bone; (2) the neural regulation of fracture healing; and (3) COVID-19 and musculoskeletal health. For each of these topics, 3 approaches to write manuscript drafts were undertaken: (1) human only; (2) ChatGPT only (AI-only); and (3) combination approach of #1 and #2 (AI-assisted). Articles were extensively fact checked and edited to ensure scientific quality, resulting in final manuscripts that were significantly different from the original drafts. Numerous parameters were measured throughout the process to quantitate advantages and disadvantages of approaches.

Recent Findings
Overall, use of AI decreased the time spent to write the review article, but required more extensive fact checking. With the AI-only approach, up to 70% of the references cited were found to be inaccurate. Interestingly, the AI-assisted approach resulted in the highest similarity indices suggesting a higher likelihood of plagiarism. Finally, although the technology is rapidly changing, at the time of study, ChatGPT 4.0 had a cutoff date of September 2021 rendering identification of recent articles impossible. Therefore, all literature published past the cutoff date was manually provided to ChatGPT, rendering approaches #2 and #3 identical for contemporary citations. As a result, for the COVID-19 and musculoskeletal health topic, approach #2 was abandoned midstream due to the extensive overlap with approach #3.

Summary
The main objective of this scientific study was to see whether AI could be used in a scientifically appropriate manner to improve the scientific writing process. Indeed, AI reduced the time for writing but had significant inaccuracies. The latter necessitates that AI cannot currently be used alone but could be used with careful oversight by humans to assist in writing scientific review articles.
Water Loss: A Postharvest Quality Marker in Apple Storage
Authors: Hasan Mahmood Ul , Singh Zora , Shah Hafiz Muhammad Shoaib , Kaur Jashanpreet , Woodward Andrew 
Published: January 2024

AbstractApple fruit can be stored for long periods of time, especially with the use of controlled atmosphere storage, but like many fruits and vegetables are susceptible to water loss. Water loss can result in compromised appearance such as skin shriveling, as well as loss of firmness, and reduced saleable weight, which in turn affect the income of growers and other industry stakeholders. Preharvest factors that can influence water loss in apples during the postharvest period include climate, cultivar, fruit size, tree age, orchard practices, and harvest maturity. Postharvest factors such as the storage temperature, relative humidity, storage type, and duration can also affect water loss in apple fruit during storage. The mechanisms of cuticle biosynthesis in water permeance, the role of stomata and lenticels, microcracking, crosstalk with mechanical injuries, storage disorders, and decay incidence during the storage of apples are reviewed. Additionally, the review summarizes: preharvest and postharvest factors influencing water loss; recent management strategies including pre-cooling, cold storage, controlled atmospheres, packaging, and anti-senescence chemicals; the use of edible coatings, as well as other non-chemical approaches for modulating water loss and maintaining storage quality. The review also provides direction for the industry to manage this destructive problem in the postharvest supply chain of apple fruit.
Energy Stability for a Class of Semilinear Elliptic Problems
Authors: Afonso Danilo Gregorin , Iacopetti Alessandro , Pacella Filomena 
Published: January 2024

AbstractIn this paper, we consider semilinear elliptic problems in a bounded domain$$\Omega $$Ωcontained in a given unbounded Lipschitz domain$${\mathcal {C}} \subset {\mathbb {R}}^N$$C⊂RN. Our aim is to study how the energy of a solution behaves with respect to volume-preserving variations of the domain$$\Omega $$Ωinside$${\mathcal {C}}$$C. Once a rigorous variational approach to this question is set, we focus on the cases when$${\mathcal {C}}$$Cis a cone or a cylinder and we consider spherical sectors and radial solutions or bounded cylinders and special one-dimensional solutions, respectively. In these cases, we show both stability and instability results, which have connections with related overdetermined problems.
Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis
Authors: Maas genannt Bermpohl Frederic , Kucharczyk-Bodenburg Ann-Cathrin , Martin Alexandra 
Published: January 2024

Abstract
Background
The systematic aggregation of research on cognitive behavioral therapy (CBT) in chronic fatigue syndrome (CFS) needs an update. Although meta-analyses evaluating interventions typically focus on symptom reduction, they should also consider indicators of treatment acceptability, e.g., drop-out rates.

Methods
Randomized controlled trials (RCTs) investigating CBT in adults with CFS compared to inactive and non-specific control groups were included. First, efficacy was examined, considering fatigue, depression, anxiety, and perceived health. Secondly, drop-out rates through different trial stages were analyzed: Non-completion of all mandatory sessions, drop-out (primary study definition), treatment refusal (non-starters), and average of sessions completed.

Result
We included 15 RCTs with 2015 participants. CBT was more effective than controls in fatigue (g = -0.52, 95%CI -0.69 to -0.35), perceived health, depression, and anxiety at post-treatment. At long-term follow-up the effects were maintained for fatigue and anxiety. Rates of non-completion (22%, 95%CI 3–71), drop-out (15%, 95%CI 9–25), and treatment refusal (7%, 95%CI 3–15) were relatively low, with a high average proportion of sessions completed. Total time of therapy moderated the effect on fatigue, while the number of sessions moderated the effect on perceived health. Fatigue severity influenced adherence.

Conclusion
The results indicate that CBT for CFS is effective in reducing fatigue, fatigue related impairment, and severity of depression and anxiety. Conclusions on efficacy at follow-ups are still limited. However, adherence is high in CBT. The results may help to inform clinical practice. Future research should focus on examining the maintenance of effects, while also emphasizing the importance of treatment acceptance.
Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype
Authors: Zhu Mengting , Rovella Valentina , Scimeca Manuel , Mauriello Alessandro , Shi Yufang , Bischof Julia , Woodsmith Jonathan , Anselmo Alessandro , Melino Gerry , Tisone Giuseppe , Agostini Massimiliano 
Published: January 2024

AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying chronic liver disease and cirrhosis. Here, we describe a case of a 62-year-old man that was admitted to our hospital and diagnosed with HCC where the cancer has already metastasized to the retroperitoneum and peritoneum. In order to better characterize the HCC, both the cancerous liver tissue and the adjacent normal liver tissue of the patient were collected and subjected to a genomic, transcriptomic and proteomic analysis. Our patient carries a highly mutated HCC, which is characterized by both somatic mutation in the following genes ALK, CDK6, TP53, PGR. In addition, we observe several molecular alterations that are associated with potential therapy resistance, for example the expression of the organic-anion-transporting polypeptide (OATP) family members B1 and B3, that mediate the transport of the anticancer drugs, has been found decreased. Overall, our molecular profiling potentially classify the patient with poor prognosis and possibly displaying resistance to pharmacological therapy.
Potential dosimetric error in the adaptive workflow of a 1.5 T MR-Linac from patient movement relative to immobilisation systems
Authors: Liu Min , Tang Bin , Orlandini Lucia Clara , Li Jie , Wang Xianliang , Peng Qian , Thwaites David 
Published: January 2024

AbstractIn magnetic resonance- (MR-) based adaptive workflows for an MR-linac, the treatment plan is optimized and recalculated online using the daily MR images. The Unity MR-linac is supplied with a patient positioning device (ppd) using pelvic and abdomen thermoplastic masks attached to a board with high-density components. This study highlights the dosimetric effect of using this in such workflows when there are relative patient-ppd displacements, as these are not visualized on MR imaging and the treatment planning system assumes the patient is fixed relative to the ppd. The online adapted plans of two example rectum cancer patients treated at a Unity MR-linac were perturbed by introducing relative patient-ppd displacements, and the effect was evaluated on plan dosimetry. Forty-eight perturbed clinical adapted plans were recalculated, based on online MR-based synthetic computed tomography, and compared with the original plans, using dose-volume histogram parameters and gamma analysis. The target volume covered by the prescribed dose ($${\text{D}}_{\text{p}\text{r}\text{e}}$$

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pre

) and by at least 107% of $${\text{D}}_{\text{p}\text{r}\text{e}}$$

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varied up to − 1.87% and + 3.67%, respectively for 0.5 cm displacements, and to − 3.18% and + 4.96% for 2 cm displacements; whilst 2%–2 mm gamma analysis showed a median value of 92.9%. The use of a patient positioning system with high-density components in a Unity MR-based online adaptive treatment workflow can introduce unrecognized errors in plan dosimetry and it is recommended not to use such a device for such treatments, without modifying the device and the workflow, followed by careful clinical evaluation, or alternatively to use other immobilization methods.
A model for problem creation: implications for teacher training
Authors: Burgos María , Tizón-Escamilla Nicolás , Chaverri Jorhan 
Published: January 2024

Abstract
The invention of problems is a fundamental competence that enhances the didactic-mathematical knowledge of mathematics teachers and therefore should be an objective in teacher training plans. In this paper, we revise different proposals for categorizing problem-creation activities and propose a theoretical model for problem posing that, based on the assumptions of the Onto-Semiotic Approach, considers both the elements that characterize a problem and a categorization of different types of problem-posing tasks. In addition, the model proposes a description of the mathematical processes that occur during the sequence of actions carried out when a new problem is created. The model is illustrated by its application to analyze the practices developed by pre-service teachers in three problem-posing tasks aimed at specific didactic-mathematical purposes (mobilizing certain mathematical knowledge or reasoning, contributing to achieving learning goals, or addressing students’ difficulties). We conclude discussing the potential of our model to analyze the mathematical processes involved in problem creation from the perspective of teacher education.
On structures of normal forms of complex points of small $${\mathcal {C}}^{2}$$-perturbations of real 4-manifolds embedded in a complex 3-manifold
Authors: Starčič Tadej 
Published: January 2024

AbstractWe extend our previous result on the behaviour of the quadratic part of a complex points of a small $${\mathcal {C}}^{2}$$

C

2

-perturbation of a real 4-manifold embedded in a complex 3-manifold. We describe the change of the structure of the quadratic normal form of a complex point. It is an immediate consequence of a theorem clarifying how small perturbations can change the bundle of a pair of one arbitrary and one symmetric $$2\times 2$$

2
×
2

matrix with respect to an action of a certain linear group.
The isomorphism problem for basic modules and the divisibility profile of the algebra of polynomials
Authors: Aydoğdu P. , Arellano C. A. , López-Permouth S. R. , Muhammad R. , Zailaee M. 
Published: January 2024

AbstractWhile mutual congeniality of bases is known to guarantee that basic modules from so-related bases are isomorphic, the question of what can be said about isomorphism of basic modules in general has remained open. We show that, for some algebras, basic modules may be non-isomorphic. We also show that it is possible, for some algebras, for all basic modules to be isomorphic, regardless of congeniality. In the process, and as a byproduct, we introduce the notion of domains of divisibility of modules over arbitrary rings. The mechanism employed here to differentiate non-isomorphic basic modules is by showing that they have different domains of divisibility. Domains of divisibility measure how divisible a module can be; for those cases when divisibility is equivalent to injectivity, domains of divisibility provide a way to gauge injectivity of modules as an alternative to the domains of injectivity and other mechanisms in the literature. We focus on the algebra of polynomials with one variable, and observe that F[x] has a full divisibility profile for any field F. When F is algebraically closed, we see that the direct product and the direct sum of all Pascal basic modules have the smallest divisibility domain. We also analyze the diversity of the family of basic modules as we explore how many of those divisibility domains correspond to basic modules. We show that, for an arbitrary infinite field F, F[x] has infinitely many pairwise non-isomorphic basic modules, the divisibility profile of F[x] is complete, and for an algebraically closed field F, the collection of basic modules has any subset S of F with a non-empty at most countable complement, the set $$\{ x + \alpha | \alpha \notin S \}$$

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x
+
α
|
α
∉
S
}

as a domain of divisibility for some basic F[x]-module.