bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Non-Medical Use of Prescription Drugs and Emotional and Behavioral Problems among Chinese Adolescents: The Mediating Effects of Social Support
Authors: chen ya , Wang Wanxin , Zhang Yexiang , Lai Wenjian , Guo Lan , Lu Ciyong , Huang Guoliang 
Published: February 2024

Abstract
Background
Less is known about the underlying role of social support in the association between non-medical use of prescription drugs (NUMPD) and emotional and behavioral Problems (EBPs). This study sought to explore association among NMUPD, social support and EBPs in Chinese youth.
Methods
A multi-stage, stratified-cluster, random-sampling method was utilized to invite 23,364 adolescents aged 10–21 years from Guangdong province to complete standard questionnaires. Data on EBPs and social support were collected using the Strengths and Difficulties Questionnaire (SDQ) and the Adolescent Social Support Scale.
Results
The reported prevalence of sedative misuse, opioid misuse and any prescription drug use (APDU) was 1.3%, 0.4% and 1.5%, respectively. Multivariable linear regression models showed that non-medical use of opioid (adjusted β estimate = 2.06, 95%CI = 1.53–2.60), sedative (adjusted β estimate = 2.15, 95%CI = 1.20–3.09) and APDU (adjusted β estimate = 1.89, 95%CI = 1.40–2.37) maintained a positive association with total difficulties. Mediation analyses showed that the standardized indirect effects of NMUPD on total difficulties mediated by social support had statistical significance (P < 0.001) and mediating effect was between 14.75% and 27.50%.
Conclusions
Significant associations exist between NMUPD and EBPs. Social support significantly mediated association between NMUPD and EBPs. Drug abuse monitoring system targeted at adolescents could be established and social support from parents, teachers and peers are highly recommended to facilitate the mental health of adolescents.
A new higher-order finite element model for free vibration and buckling of functionally graded sandwich beams with porous core resting on a two-parameter elastic foundation using quasi-3D theory
Authors: Mohamed Ibrahim , Kahya Volkan , Şimşek Sebahat 
Published: February 2024

Abstract

In this paper, a new higher-order finite element model is proposed for free vibration and buckling analysis of functionally graded (FG) sandwich beams with porous core resting on a two-parameter Winkler-Pasternak elastic foundation based on quasi-3D deformation theory. The material properties of FG sandwich beams vary gradually through the thickness according to the power-law distribution. The governing equation of motion is derived from the Lagrange's equations. Three different porosity patterns including uniform, symmetric, and asymmetric are considered. The accuracy and convergence of the proposed model are verified with several numerical examples. A comprehensive parametric study is carried out to explore the effects of the boundary conditions, skin-to-core thickness ratio, power-law index, slenderness, porosity coefficient, porous distribution of the core, and elastic foundation parameters on the natural frequencies and critical buckling loads of FG sandwich beams.
Listening to Each Other: A collaborative 2D hydraulic model to examine water and sediment availability in an inland delta
Authors: Sabokruhie Pouya , Duffy Ashleigh , Mohammadiazar Azza , Carriere Gary , McKay Kelvin , Lindenschmidt Karl-Erich , Strickert Graham , Jardine Timothy , Bradford Lori 
Published: February 2024

Abstract

The Saskatchewan River Delta is the largest inland freshwater delta in North America. The delta has been inhabited by humans for at least 7,000 years, but this complex social-ecological system has been disrupted by reduced water and sediment flows due to upstream water resource development. To follow up on previous on-land participant observations and semi-structured interviews that documented changes to the delta, a two-dimensional (2D) hydraulic HEC-RAS model was set up to collaboratively determine future scenarios. The model domain contains the main channel, floodplains, and hinterland areas while observed meteorological and hydrological data were used to force and calibrate the model. The model considered recent observations, examining scenarios with and without different mitigation measures to improve water availability and sediment transport within the delta. Modellers and residents jointly chose to focus on the strategic placement of weirs to raise the water depth in the delta's largest lake (Cumberland Lake) as a practical method. The model's ability to visualize and animate results has been serving as a boundary object, allowing crucial conversations about water to occur within and between community members and upstream water decision-makers. This paper discusses lessons learned from collaborative modelling that may provide insight beyond this important delta system.
CpCOR1 gene positively regulates cold tolerance and antioxidant activity of papaya fruit under postharvest cold shock treatment
Authors: Nian yuwei , Aslam Muhammad Muzammal , Zou shicheng , Jia wenjun , Li rui , wen li , Shao yuanzhi 
Published: February 2024

Abstract
Inappropriate low temperatures can induce harmful effects on post-harvest papaya fruit, a phenomenon known as "chilling injury." This study aims to elucidate the role of CpCOR1, a gene encoding a cold-regulated protein, in the manifestation of low temperature-induced chilling injury in papaya fruit. Our results demonstrate that cold shock treatment (CST, 2 ℃ ice-water for 0.5 h) significantly reduced the chilling injury index (CII), concurrently preserving the cell microstructure and mitigating the increase in cell membrane permeability during both 5 ℃ and 25 ℃ storage. Transcriptome analysis and qRT-PCR revealed a substantial up-regulation of the CpCOR1 gene in CST papaya fruit compared to the control fruit. Furthermore, bioinformatics and phylogenetic tree analysis identified CpCOR1 as a basic hydrophobic protein with a coding sequence of 606 bp and an amino acid sequence of 201 aa, classifying it under the COR413 subgroup. Sub-cellular localization assays confirmed that CpCOR1 is primarily localized to the cell membrane. Moreover, overexpression of CpCOR1 in tobacco leaves and papaya fruit significantly alleviated chilling injury symptoms, suppressed yellowing, reduced malondialdehyde (MDA) accumulation, and maintained higher activities of antioxidant enzymes, including catalase (CAT) and ascorbate peroxidase (APX), compared to the control group. In summary, our findings suggest that cold shock treatment is an effective strategy to retard the onset of low-temperature damage, with CpCOR1 playing a pivotal role in enhancing cold resistance and delaying ripening by activating antioxidant activity in papaya fruit.
Survival outcomes in HER2-low versus HER2-zero breast cancer after neoadjuvant chemotherapy:a meta-analysis
Authors: Xia Lin-Yu , Cao Xu-Chen , Yu Yue 
Published: February 2024

Abstract
Background
The survival outcomes in HER2-low versus HER2-zero breast cancer after neoadjuvant chemotherapy (NACT) remain unclear. The meta-analysis was conducted to summarize current evidence about the survival outcomes in HER2-low versus HER2-zero breast cancer.
Methods
We conducted a systematic search in PubMed and EMBASE databases to identify relevant studies.
Results
A total of 14 studies with 53726 patients were included. Overall, 34037 patients (63.37%) were HER2-low, and 19677 patients (36.63%) were HER2-zero. Patients with HER2-low tumors had a significantly lower pathological complete response (pCR) rate than patients with HER2-zero tumors, regardless of the hormone receptor status. Compared with HER2-zero breast cancer, the overall survival (OS) and disease-free survival (DFS) of HER2-low breast cancer were longer in the overall cohort ((HR = 0.72; 95% CI = 0.61–0.85; P < 0.0001; HR = 0.83; 95% CI = 0.75–0.92; P = 0.0002); however, no differences were observed in terms of OS and DFS between HER2-low and HER2-zero breast cancer in the HR-negative group. In the HR-positive group, HER2-low status had no significant impact on OS, while significantly associated with increased DFS (HR = 0.85; 95% CI = 0.76–0.96; P = 0.007).
Conclusion
These results suggest that HER2-low breast cancer was correlated with favorable OS and DFS after NACT in the overall cohort as well as longer DFS in the HR-positive group; however, there were no significant differences noted for OS or DFS in other groups.
Inspiratory Crackles in Idiopathic Pulmonary Fibrosis – Friend or Foe for Early Diagnosis?
Authors: Lang David , Lamprecht Bernd , Bishop Nesrin Mogulkoc , Sterclova Martina , Lewandowska Katarzyna , Kramer Mordechai , Bartos Vladimir , Plackova Martina , Müller Veronika , Ovesna Petra , Studnicka Michael , Vasakova Martina Koziar 
Published: February 2024

Abstract
Background:
Velcro crackles (VCR) are frequent in idiopathic pulmonary fibrosis (IPF) patients and have been advocated as a tool for early diagnosis. We assessed their association with clinical features, progression, and survival in the European MultiPartner IPF Registry (EMPIRE).
Methods:
Clinical, imaging, and pulmonary function data were collected at baseline and followed up at least every six months. Cross-sectional analyses of baseline characteristics were performed for all and separately for incident IPF patients diagnosed within 6 months before inclusion. Progression-free (PFS) and overall survival (OS) were calculated by Kaplan–Meier estimates, progression was defined using different thresholds of FVC and DLCO decline, lung transplantation, and death. Annual FVC decline was calculated using a restricted maximum likelihood estimation based on a random slope and intercept model.
Results:
Of 4583 IPF patients (71% men, median age 70 (IQR 64–75)), 89% had VCR at enrollment. Patients with VCR were older, had a longer symptom duration and a higher prevalence of exertional dyspnea, cough, and finger clubbing. Also, they presented with lower FVC and DLCO, with a higher GAP stage, and more frequently had a definite usual interstitial pneumonia pattern on computed tomography. Neither PFS nor OS differed significantly according to presence of VCR in all and in incident patients. Adjusted FVC decline rate was significantly higher in all patients with velcro crackles (-0.102mL (95% CI -0.113; -0.091) vs. -0.056mL (-0.09; -0.023), p = 0.011).
Conclusions:
Most patients in EMPIRE presented with VCR and patients without VCR had less severe functional impairment and a shorter symptom duration. This supports the current role of auscultation as a primary care diagnostic tool but may challenge its alleged role in early diagnosis of IPF.
Toward a Frontierless Collaboration in Neurosurgery: A Systematic Review of Remote Augmented and Virtual Reality Technologies
Authors: Bocanegra-Becerra Jhon E. , Sánchez José Luis Acha , Castilla-Encinas Adriam M. , Rios-Garcia Wagner , Mendieta Cristian D. , Quiroz-Marcelo Diego A. , Alhwaishel Khaled , Aguilar-Zegarra Luis , Lopez-Gonzalez Miguel Angel 
Published: February 2024

Abstract

Introduction Augmented Reality (AR) and Virtual Reality (VR) technologies have been introduced to Neurosurgery with the goal of improving the experience of human visualization. In recent years, the application of remote AR and VR has opened new horizons for neurosurgical collaboration across diverse domains of education and patient treatment. Herein, we aimed to systematically review the literature about the feasibility of this technology and discuss the technical aspects, current limitations, and future perspectives.Methods Following the PRISMA guidelines, four databases (PubMed, Embase, Scopus, and Cochrane Library) were queried for articles discussing the use of remote AR and VR technologies in Neurosurgery. Data were collected in various fields, including surgery type, application type, subspecialty, software and hardware descriptions, haptic device utilization, visualization technology, internet connection, remote site descriptions, technical outcomes, and limitations. Data were summarized as counts and proportions and analyzed using IBM® SPSS® software.Results Our search strategy generated 466 records, out of which 9 studies satisfied the inclusion criteria. The majority of AR and VR applications were used in cranial procedures (77.8%), mainly in education (63.6%), followed by telesurgical assistance (18.2%), patient monitoring (9.1%), and surgical planning (9.1%). Local collaborations were established in 55.6% of the studies, while national and international partnerships were formed in 44.4% of the studies. AR was the main visualization technology, and 3G internet connection was predominantly used (27.5%). All studies subjectively reported the utility of remote AR and VR for real-time interaction. The major technical challenges and limitations included audiovisual latency, the requirement for higher-fidelity and resolution image reconstructions, and the level of proficiency of the patient with the software.Conclusion The results from this systematic review suggest that AR and VR technologies are dynamically advancing to offer remote collaboration in Neurosurgery. Although still incipient in development and with an imperative need for technical improvement, remote AR and VR hold a frontierless potential for patient monitoring, neurosurgical education, and long-distance surgical assistance.
Hypofractionated radiotherapy with simultaneous tumor bed boost (Hi-RISE) in breast cancer patients receiving upfront breast-conserving surgery: study protocol for a phase III randomized controlled trial
Authors: Jin Kairui , Luo Jurui , Yu Xiaoli , Guo Xiaomao 
Published: February 2024

Abstract
Background: The effectiveness and safety of moderately hypofractionated radiotherapy (HFRT) in patients undergoing breast-conserving surgery (BCS) has been demonstrated in several pivotal randomized trials. However, the feasibility of applying simultaneous integrated boost (SIB) to the tumor bed and regional node irradiation (RNI) using modern radiotherapy techniques with HFRT needs further evaluation.
Methods: This prospective, multi-center, randomized controlled, non-inferiority phase III trial aims to determine the non-inferiority of HFRT combined with SIB (HFRTsib) compared with conventional fractionated radiotherapy with sequential boost (CFRTseq) in terms of five-year locoregional control rate in breast cancer patients undergoing upfront BCS. A total of 2904 participants will be recruited and randomized in a 1:1 ratio into the HFRTsib and CFRTseq groups. All patients will receive whole breast irradiation, and those with positive axillary nodes will receive additional RNI, including internal mammary irradiation. The prescribed dose for the HFRTsib group will be 40 Gy in 15 fractions, combined with a SIB of 48 Gy in 15 fractions to the tumor bed. The CFRTseq group will receive 50 Gy in 25 fractions, with a sequential boost of 10 Gy in 5 fractions to the tumor bed.
Discussion: This trial intends to assess the effectiveness and safety of SIB combined with HFRT in early breast cancer patients following BCS. The primary endpoint is locoregional control, and the results of this trial are expected to offer crucial evidence for utilizing HFRT in breast cancer patients after BCS.
Trial registration: This trial was registered at ClincalTrials.gov (NCT04025164) on July 18, 2019.
Impact of microRNA-122 and microRNA-370 on insulin resistance and risk of cardiovascular diseases in obese Egyptian children
Authors: Abdou Shimaa Metwally , El-Maksoud Awatif Mohammed Abd , Ahmed Gihan Fouad , El-Aziz Heba Gamal Abd 
Published: February 2024

Abstract
Background: Childhood obesity represents a serious worldwide problem with many short and long-term significant health consequences. This study aimed to assess the expression levels of microRNA-122 and microRNA-370, and their possible correlation with insulin resistance and cardiovascular diseases in obese Egyptian children.
Methods: Seventy obese children aged 5-10 years and thirty age-matched normal weight children as control were enrolled. All children were subjected to anthropometric, systolic, and diastolic blood pressure measurements as well as the expression of circulating of microRNA-122 and microRNA-370 was measured by quantitative real-time polymerase chain reaction amplification. Serum biochemical parameters (glucose, insulin, total cholesterol, triglycerides, LDL, and HDL) levels were determined. The homeostasis model assessment version 2 (HOMA2) was used to evaluate pancreatic beta cell function (HOMA2-%B), insulin resistance (HOMA2-IR), and insulin sensitivity (HOMA2-%S). Insulin sensitivity was further assessed by the single-point insulin sensitivity estimator (SPISE) index and McAuley index.
Results: Compared with control group, the weight, BMI, fasting blood glucose, triglycerides, total cholesterol, LDL, VLDL, non-HDL cholesterol, cardiac risk ratio 1, cardiac risk ratio 2, atherogenic coefficient, atherogenic index, insulin levels, HOMA2-%B, HOMA2-IR and microRNA-122 were significantly increased (P < 0.001). MicroRNA-122 showed significant positive correlations with cardiac risk ratio 1 and atherogenic coefficient, however, a significant negative correlation with HDL in obese group. On the other hand, HOMA2-%S, McAuley and SPISE insulin sensitivity indices, HDL and microRNA-370 were significantly decreased.
Conclusions: Changes in serum level of microRNA-122 and microRNA-370 in obese children may suggest a possible role in the pathogenesis of childhood obesity and their accompanied complications. Therefore, they can serve as early biomarkers and possible predictors for future metabolic dysfunction.
Prediction Study of Thermoelectric Properties of TiO2 Nanoparticles and Effect on PVA/SiO 2 Hybrid Films Synthesized by sol-gel Method
Authors: Gueridi B. , Slimani Y. , Bouferrache K. , Ghebouli M. A. , Rouabah F. , Chihi T. , Fatmi M. , Ghebouli B. , Djemli A. , Alotaibi Nouf H. , Mohammad Saikh , Benali A. 
Published: February 2024

Abstract
We use an ab initio approach to look into the structural, electronic band structure, and thermoelectric properties of titanium dioxide (TiO2 in rutile phase), and we then use TiO2 to create its effects on sol-gel-produced polyvinyl alcohol/silicon dioxide (PVA/SiO2) hybrid films. The synthesis of the hybrid films involved the incorporation of 1% TiO2 nanoparticles in the PVA/SiO2 matrix. The thermoelectric properties of the resulting hybrid films were characterized through measurements of the Seebeck coefficient, electrical conductivity, and thermal conductivity. The findings show that the thermoelectric performance of the PVA/SiO2 hybrid films is greatly improved by TiO2 nanoparticles are added to the rutile phase, with an optimal concentration (1%) of TiO2 nanoparticles. This study provides insights into the potential applications of TiO2 nanoparticles in enhancing the thermoelectric properties of hybrid materials and opens up avenues for further research in this area, and contributes to the growing body of knowledge on enhancing the thermoelectric properties of materials by incorporating TiO2 nanoparticles into hybrid films synthesized by the sol-gel method.
The development of WC-Co cemented carbide slurry for stereolithography- based additive manufacturing
Authors: Tan Jinlin , Chen Yongan , Ling Xile , Guo Hongshan , Sun Jinxing , Zhao Saijin , Liu Yang , Bai Jiaming , Zhou Peng , Zhang Dongyang , Gong Feng 
Published: February 2024

Abstract
Tungsten carbide-cobalt (WC-Co) cemented carbide has a wide range of application prospects in a wide range of industries because of its high strength, high hardness, excellent wear resistance, high temperature resistance, corrosion resistance, etc. Additive manufacturing (AM) makes it possible to fabricate geometrically complex tools compared to traditional manufacturing techniques. However, the preparation of high solid loading, superior stability, and optimal curing thickness of WC-Co cemented carbide slurry remains challenging for creating cemented carbide components with complex shapes via stereolithography. In this work, the dispensability, stability, and curing thickness of WC-Co cemented carbide slurry were systematically investigated. The suitable WC-Co (94-6wt.%) cemented carbide slurry for stereolithography was successfully achieved by ball milling under appropriate process parameters, and the complex-shaped WC-Co (94-6wt.%) cemented carbide green bodies were fabricated. This work aims to provide a reference for additive manufacturing of near-net-shape WC-Co cemented carbide parts by stereolithography.
A Neurosurgical Perspective on Electric Scooter Accidents
Authors: Özlü Eylem Burcu Kahraman , Mutlu Elcin Tugce , Durmus Kaan , Calisaneller Arif Tarkan 
Published: February 2024

Abstract
Purpose
Electric scooters (e-scooters) have become the preferred personal vehicles in the world with their easy accessibility and fast and even environmentally friendly features in urban transportation. E-scooters started to be used in Istanbul for the first time in Turkiye in 2019 and became popular in other metropolitans over time. We started encountering associated injuries in our clinic with the growing use of e-scooters.
Methods
This study evaluated 242 patients, who were admitted to the Emergency Department of our hospital, due to electric scooter accidents between January 2020 and May 2023, retrospectively for neurosurgical pathologies.
Results
Among the 12 patients included in the study, 8 were male and 34 were female. The mean age was 26.6 (14–50). It was determined that none of them used protective equipment (helmet, knee pad, etc.). According to the retrospective evaluation, two patients were followed up for mild head trauma, seven for moderate head trauma, and one for severe head trauma. One patient with severe head trauma required a long hospital stay and repeated surgical intervention. One patient was treated with conservative follow-up and the other required surgery.
Conclusion
Electric scooters are environmentally friendly and accelerate transportation; however, using them without complying with protective equipment and traffic rules causes severe traumas. Despite our limited number of patients, we monitored one patient with trauma progressing with severe morbidity. We think we will encounter injuries related to e-scooters more frequently in the neurosurgery emergency practice.