bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Ocean Thermocline Temperatures on the Earth’s Surface Climate
Authors: Oglesby Robert J. , Stephens Monica Y. , Saltzman Barry 
Published: August 2005

Abstract
A coupled mixed layer–atmospheric general circulation model has been used to evaluate the impact of ocean thermocline temperatures (and by proxy those of the deep ocean) on the surface climate of the earth. Particular attention has been devoted to temperature regimes both warmer and cooler than at present. The mixed layer ocean model (MLOM) simulates vertical dynamics and thermodynamics in the upper ocean, including wind mixing and buoyancy effects, and has been coupled to the NCAR Community Climate Model (CCM3). Simulations were made with globally uniform thermocline warmings of +2°, +5°, and +10°C, as well as a globally uniform cooling of −5°C. A simulation was made with latitudinally varying changes in thermocline temperature such that the warming at mid- and high latitudes is much larger than at low latitudes. In all simulations, the response of surface temperature over both land and ocean was larger than that expected just as a result of the imposed thermocline temperature change, largely because of water vapor feedbacks. In this respect, the simulations were similar to those in which only changes in atmospheric carbon dioxide were imposed. In fact, when carbon dioxide was explicitly changed along with thermocline temperatures, the results were not much different than if only the thermocline temperatures were altered. Land versus ocean differences are explained largely by latent heat flux differences: the ocean is an infinite evaporative source, while land can be quite dry. The latitudinally varying case has a much larger response at mid- to high latitudes than at low latitudes; the high latitudes actually appear to effectively warm the low latitudes. Simulations exploring scenarios of glacial inception suggest that the deep ocean alone is not likely to be a key trigger but must operate in conjunction with other forcings, such as reduced carbon dioxide. Moist upland regions at mid- and high latitudes, and land regions adjacent to perennial sea ice, are the preferred locations for glacial inception in these runs. Finally, the model combination equilibrates very rapidly, meaning that a large number of simulations can be made for a fairly modest computational cost. A drawback to this is greatly reduced sensitivity to parameters such as atmospheric carbon dioxide, which requires a full response of the ocean. Thus, this approach can be considered intermediate between fixing, or prescribing, sea surface temperatures and a fully coupled modeling approach.
A Bayesian Climate Change Detection and Attribution Assessment
Authors: Lee Terry C. K. , Zwiers Francis W. , Hegerl Gabriele C. , Zhang Xuebin , Tsao Min 
Published: August 2005

Abstract
A Bayesian analysis of the evidence for human-induced climate change in global surface temperature observations is described. The analysis uses the standard optimal detection approach and explicitly incorporates prior knowledge about uncertainty and the influence of humans on the climate. This knowledge is expressed through prior distributions that are noncommittal on the climate change question. Evidence for detection and attribution is assessed probabilistically using clearly defined criteria. Detection requires that there is high likelihood that a given climate-model-simulated response to historical changes in greenhouse gas concentration and sulphate aerosol loading has been identified in observations. Attribution entails a more complex process that involves both the elimination of other plausible explanations of change and an assessment of the likelihood that the climate-model-simulated response to historical forcing changes is correct. The Bayesian formalism used in this study deals with this latter aspect of attribution in a more satisfactory way than the standard attribution consistency test. Very strong evidence is found to support the detection of an anthropogenic influence on the climate of the twentieth century. However, the evidence from the Bayesian attribution assessment is not as strong, possibly due to the limited length of the available observational record or sources of external forcing on the climate system that have not been accounted for in this study. It is estimated that strong evidence from a Bayesian attribution assessment using a relatively stringent attribution criterion may be available by 2020.
Sensitivity of the Ocean’s Climate to Diapycnal Diffusivity in an EMIC. Part II: Global Warming Scenario
Authors: Dalan Fabio , Stone Peter H. , Sokolov Andrei P. 
Published: August 2005

Abstract
The sensitivity of the ocean’s climate to the diapycnal diffusivity in the ocean is studied for a global warming scenario in which CO2 increases by 1% yr−1 for 75 yr. The thermohaline circulation slows down for about 100 yr and recovers afterward, for any value of the diapycnal diffusivity. The rates of slowdown and of recovery, as well as the percentage recovery of the circulation at the end of 1000-yr integrations, are variable, but a direct relation with the diapycnal diffusivity cannot be found. At year 70 (when CO2 has doubled) an increase of the diapycnal diffusivity from 0.1 to 1.0 cm2 s−1 leads to a decrease in surface air temperature of about 0.4 K and an increase in sea level rise of about 4 cm. The steric height gradient is divided into thermal component and haline component. It appears that, in the first 60 yr of simulated global warming, temperature variations dominate the salinity ones in weakly diffusive models, whereas the opposite occurs in strongly diffusive models.
The analysis of the vertical heat balance reveals that deep-ocean heat uptake is due to reduced upward isopycnal diffusive flux and parameterized-eddy advective flux. Surface warming, induced by enhanced CO2 in the atmosphere, leads to a reduction of the isopycnal slope, which translates into a reduction of the above fluxes. The amount of reduction is directly related to the magnitude of the isopycnal diffusive flux and parameterized-eddy advective flux at equilibrium. These latter fluxes depend on the thickness of the thermocline at equilibrium and hence on the diapycnal diffusion. Thus, the increase of deep-ocean heat uptake with diapycnal diffusivity is an indirect effect that the latter parameter has on the isopycnal diffusion and parameterized-eddy advection.
The Water and Energy Budget of the Arctic Atmosphere
Authors: Semmler Tido , Jacob Daniela , Schlünzen K. Heinke , Podzun Ralf 
Published: August 2005

Abstract
The Arctic plays a major role in the global circulation, and its water and energy budget is not as well explored as that in other regions of the world. The aim of this study is to calculate the climatological mean water and energy fluxes depending on the season and on the North Atlantic Oscillation (NAO) through the lower, lateral, and upper boundaries of the Arctic atmosphere north of 70°N. The relevant fluxes are derived from results of the regional climate model (REMO 5.1), which is applied to the Arctic region for the time period 1979–2000. Model forcing data are a combination of 15-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-15) data and analysis data. The annual and seasonal total water and energy fluxes derived from REMO 5.1 results are very similar to the fluxes calculated from observational and reanalysis data, although there are some differences in the components. The agreement between simulated and observed total fluxes shows that these fluxes are reliable. Even if differences between high and low NAO situations occur in our simulation consistent with previous studies, these differences are mostly smaller than the large uncertainties due to a small sample size of the NAO high and low composites.
On the nature of cancer and why anticancer vaccines don't work
Authors: Prehn Richmond T 
Published: August 2005

Abstract
In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The lack of antigenicity, despite extensive genomic instability, could be explained if most tumor mutations occur in silenced genes. A further problem is that an immune reaction against tumor antigens, especially in moderate or low amount, may be stimulatory rather than inhibitory to tumor growth.
Psychosocial predictors of eating habits among adults in their mid-30s: The Oslo Youth Study follow-up 1991–1999
Authors: Kvaavik Elisabeth , Lien Nanna , Tell Grethe S , Klepp Knut-Inge 
Published: August 2005

Abstract
Background
The predictive value of the psychosocial constructs of Theory of Planned Behaviour (TPB) on subsequent dietary habits has not been previously investigated in a multivariate approach that includes demographic factors and past dietary behaviour among adults. The aim of this study was to investigate to what extent TPB constructs, including intention, attitudes, subjective norms, perceived behavioural control, and perceived social norms, measured at age 25 predicted four eating behaviours (intake of fruits and vegetables, whole grains, total fat and added sugar) eight years later.

Methods
Two hundred and forty men and 279 women that participated in the Oslo Youth Study were followed from 1991 to 1999 (mean age 25 and 33 years, respectively). Questionnaires at baseline (1991) included the constructs of the TPB and dietary habits, and at follow-up (1999) questionnaires included demographic factors and diet. For the assessment of diet, a food frequency questionnaire (FFQ) with a few food items was used at baseline while an extensive semi-quantitative FFQ was used at follow-up.

Results
Among men, attitudes, subjective norms and previous eating behaviour were significant predictors of fruit and vegetable intake, while education and past eating behaviour were predictive of whole grain intake in multivariate analyses predicting dietary intake at follow-up. For women, perceived behavioural control, perceived social norms and past behaviour were predictive of fruit and vegetable intake, while subjective norms, education and past eating behaviour were predictive of whole grain intake. For total fat intake, intention was predictive for men and perceived behavioural control for women. Household income and past consumption of sugar-rich foods were significant predictors of added sugar intake among men, while past intake of sugar-rich foods was a significant predictor of added sugar intake among women.

Conclusion
After adjusting for potential confounding factors, all psychosocial factors assessed among young adults appeared predictive of one or more eating behaviours reported eight years later. Results point to the influence of psychosocial factors on future eating behaviours and the potential for interventions targeting such factors.
HIV/AIDS: global trends, global funds and delivery bottlenecks
Authors: Coovadia Hoosen M , Hadingham Jacqui 
Published: August 2005

AbstractGlobalisation affects all facets of human life, including health and well being. The HIV/AIDS epidemic has highlighted the global nature of human health and welfare and globalisation has given rise to a trend toward finding common solutions to global health challenges. Numerous international funds have been set up in recent times to address global health challenges such as HIV.However, despite increasingly large amounts of funding for health initiatives being made available to poorer regions of the world, HIV infection rates and prevalence continue to increase world wide. As a result, the AIDS epidemic is expanding and intensifying globally. Worst affected are undoubtedly the poorer regions of the world as combinations of poverty, disease, famine, political and economic instability and weak health infrastructure exacerbate the severe and far-reaching impacts of the epidemic.One of the major reasons for the apparent ineffectiveness of global interventions is historical weaknesses in the health systems of underdeveloped countries, which contribute to bottlenecks in the distribution and utilisation of funds. Strengthening these health systems, although a vital component in addressing the global epidemic, must however be accompanied by mitigation of other determinants as well. These are intrinsically complex and include social and environmental factors, sexual behaviour, issues of human rights and biological factors, all of which contribute to HIV transmission, progression and mortality. An equally important factor is ensuring an equitable balance between prevention and treatment programmes in order to holistically address the challenges presented by the epidemic.
Urinary diseases and ethnobotany among pastoral nomads in the Middle East
Authors: Abu-Rabia Aref 
Published: August 2005

Abstract
This article is derived from a broad, twenty-year study of ethnobotany and folk medicine among pastoral nomads in the Middle East which took place from 1984 to 2004. The article presents examples of different treatments of diseases and disorders of the urinary tract carried out by healer herbalists. The preparation of remedies includes boiling infusions, extraction of dry or fresh leaves, flowers, seeds or whole plants. Some of these plants were used both as food and as medicine, by ingesting different parts of the plants, such as leaves, flowers, fruits, and so on, either while soft, cooked or dried. Data were collected by using unstructured interviews and by observation. These plants were identified by healers, patients, and university botanists. This paper identified eighty-five plant species, which belong to thirty-six families. The most representative families are: Asteraceae (8), Brassicaceae (6), Poaceae (6), Umbelliferae (6).
Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression
Authors: Carvalho Inês , Milanezi Fernanda , Martins Albino , Reis Rui M , Schmitt Fernando 
Published: August 2005

Abstract
Introduction
Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers. Platelet-derived growth factor receptors (PDGFRs) are receptors with intrinsic tyrosine kinase activity that regulate several functions in normal cells and are widely expressed in a variety of malignancies. After the demonstration that gastrointestinal stromal tumours without c-Kit mutations harbour PDGFR-α-activating mutations and that PDGFR-α is also a therapeutic target for imatinib mesylate, the interest for this receptor has increased considerably. Because breast cancer is one of the most frequent neoplasias in women worldwide, and only one study has reported PDGFR-α expression in breast carcinomas, the aim of this work was to investigate the potential significance of PDGFR-α expression in invasive mammary carcinomas.

Methods
We used immunohistochemistry to detect PDGFR-α overexpression on a series of 181 formalin-fixed paraffin-embedded invasive ductal breast carcinomas and in two breast cancer cell lines: MCF-7 and HS578T. We associated its expression with known prognostic factors and we also performed polymerase chain reaction–single-stranded conformational polymorphism and direct sequencing to screen for PDGFR-α mutations.

Results
PDGFR-α expression was observed in 39.2% of the breast carcinomas and showed an association with lymph node metastasis (P = 0.0079), HER-2 expression (P = 0.0265) and Bcl2 expression (P = 0.0121). A correlation was also found with the expression of platelet-derived growth factor A (PDGF-A; P = 0.0194). The two cell lines tested did not express PDGFR-α. Screening for mutations revealed alterations in the PDGFR-α gene at the following locations: 2500A→G, 2529T→A and 2472C→T in exon 18 and 1701G→A in exon 12. We also found an intronic insertion IVS17-50insA at exon 18 in all sequenced cases. None of these genetic alterations was correlated with PDGFR-α expression. The cell lines did not reveal any alterations in the PDGFR-α gene sequence.

Conclusion
PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness. The genetic alterations described were not correlated with protein expression, but other mechanisms such as gene amplification or constitutive activation of a signalling pathway inducing this receptor could still sustain PDGFR-α as a potential therapeutic target.
Tumoral and Immunologic Response After Vaccination of Melanoma Patients With an ALVAC Virus Encoding MAGE Antigens Recognized by T Cells
Authors: van Baren Nicolas , Bonnet Marie-Claude , Dréno Brigitte , Khammari Amir , Dorval Thierry , Piperno-Neumann Sophie , Liénard Danielle , Speiser Daniel , Marchand Marie , Brichard Vincent G. , Escudier Bernard , Négrier Sylvie , Dietrich Pierre-Yves , Maraninchi Dominique , Osanto Susanne , Meyer Ralf G. , Ritter Gerd , Moingeon Philippe , Tartaglia Jim , van der Bruggen Pierre , Coulie Pierre G. , Boon Thierry 
Published: August 2005

PurposeTo evaluate the toxicity, antitumoral effectiveness, and immunogenicity of repeated vaccinations with ALVAC miniMAGE-1/3, a recombinant canarypox virus containing a minigene encoding antigenic peptides MAGE-3168-176and MAGE-1161-169, which are presented by HLA-A1 and B35 on tumor cells and can be recognized by cytolytic T lymphocytes (CTLs).Materials and MethodsThe vaccination schedule comprised four sequential injections of the recombinant virus, followed by three booster vaccinations with the MAGE-3168-176and MAGE-1161-169peptides. The vaccines were administered, both intradermally and subcutaneously, at 3-week intervals.ResultsForty patients with advanced cancer were treated, including 37 melanoma patients. The vaccines were generally well tolerated with moderate adverse events, consisting mainly of transient inflammatory reactions at the virus injection sites. Among the 30 melanoma patients assessable for tumor response, a partial response was observed in one patient, and disease stabilization in two others. The remaining patients had progressive disease. Among the patients with stable or progressive disease, five showed evidence of tumor regression. A CTL response against the MAGE-3 vaccine antigen was detected in three of four patients with tumor regression, and in only one of 11 patients without regression.ConclusionRepeated vaccination with ALVAC miniMAGE-1/3 is associated with tumor regression and with a detectable CTL response in a minority of melanoma patients. There is a significant correlation between tumor regression and CTL response. The contribution of vaccine-induced CTL in the tumor regression process is discussed in view of the immunologic events that could be analyzed in detail in one patient.
Erythrocyte Zinc Protoporphyrin Is Elevated With Prematurity and Fetal Hypoxemia
Authors: Lott David G. , Zimmerman M. Bridget , Labbé Robert F. , Kling Pamela J. , Widness John A. 
Published: August 2005

Objective. To examine the utility of red blood cell (RBC) zinc protoporphyrin/heme ratio (ZnPP/H) as an indicator of fetal iron status, because unfavorable neurodevelopmental outcomes have been associated with poor iron status at birth, as indicated by low serum ferritin, and because few reliable indicators of fetal and early neonatal iron status exist.
Methods. Consecutively studied preterm and term fetuses at delivery included the following groups: (1) control nonhypoxic, (2) fetuses with intrauterine growth retardation (IUGR), and (3) fetuses of insulin-treated mothers (FDM). We hypothesized (1) that rapid growth velocity associated with an accelerated erythropoiesis among normal fetuses will lead to reduced iron delivery to a rapidly expanding RBC mass and higher umbilical cord blood RBC ZnPP/H and (2) that fetuses that are exposed to pathologic hypoxemia will experience an additional increase in erythropoiesis and higher cord ZnPP/H. ZnPP/H was determined on saline-washed cord blood erythrocytes by hematofluorometry and was examined for its relationship with clinical factors and cord blood laboratory measurements indicative of tissue oxygenation (plasma erythropoietin [EPO] and reticulocyte count) and iron status (plasma ferritin and erythrocyte indices). Statistical testing included 1-way analysis of variance, 2-way analysis of variance with covariates, simple linear regression, and multiple regression analysis.
Results. Among control group subjects, gestational age at birth was inversely correlated with RBC ZnPP/H and reticulocyte count and positively correlated with ferritin and EPO. Relative to control subjects, IUGR and FDM fetuses at specified gestational age groupings had higher ZnPP/H, lower plasma ferritin, and higher plasma EPO. Statistical modeling of the relationship between ZnPP/H and plasma ferritin among all study groups demonstrated significant impacts of gestational age, plasma EPO, maternal hypertension, and maternal smoking.
Conclusions. The inverse association of fetal ZnPP/H with gestational age at birth among control subjects is attributable to erythropoietic stimulation likely as a result of increasing growth velocity at the earliest gestational ages. The relatively higher ZnPP/H observed among fetuses in the IUGR and FDM groups likely is attributable to increased erythropoietic activity secondary to pathologic hypoxemia. Decreased placental iron transfer may also have limited iron availability and contributed to elevated ZnPP/H in the IUGR group. These data support the concept that increased erythropoietic activity and/or limited iron transport may place infants of diabetic mothers and infants with growth retardation at risk for developing systemic iron deficiency later in infancy and in early childhood.
Randomized, Controlled Trial of Dexamethasone in Neonatal Chronic Lung Disease: 13- to 17-Year Follow-up Study: II. Respiratory Status, Growth, and Blood Pressure
Authors: Jones Rosamond A. K. ,   on behalf of the Collaborative Dexamethasone Trial Follow-up Group
Published: August 2005

Objectives. To study the growth, health status, and respiratory outcomes at 13 to 17 years of infants enrolled in a double-blind, randomized, controlled trial of dexamethasone for the treatment of neonatal chronic lung disease.Participants. A total of 287 infants who were chronically dependent on supplementary oxygen between 2 and 12 weeks of age were recruited from 31 centers in 6 countries to a double-blind, randomized, controlled trial of dexamethasone base (0.5 mg/kg per day for 1 week) or placebo, and survivors were evaluated at 3 years. Children from the 25 British and Irish centers were traced for reassessment at 13 to 17 years of age.Outcome Measures. Respiratory symptoms, lung-function testing, height, weight, head circumference, blood pressure, health resource usage, and school absences.Results. There was no significant difference in respiratory outcomes between the dexamethasone and placebo groups. Lung function was impaired but with no difference between the 2 groups. Growth was also impaired in both groups, with height z score of −0.7, weight z score of −0.4, and head circumference z score of −1.1. Systolic blood pressure was &gt;95th percentile for age and height for 15% of children, but with no difference between the 2 groups. There was no difference in the numbers of hospital admissions for respiratory causes or other causes.Conclusions. Despite a shorter duration of neonatal assisted ventilation, there is no evidence that dexamethasone use is associated with long-term improvement in lung function. Impaired growth and poor health status are long-term consequences of neonatal chronic lung disease, irrespective of exposure to neonatal dexamethasone.