bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists
Authors: Rho Nark Kyoung , Han Kwang Ho , Cho Minah , Kim Hei Sung 
Published: December 2023

AbstractBackgroundSkin boosters denote injectables that promote global improvement of the skin which includes skin texture, elasticity, hydration, and overall appearance. Polynucleotide (PN) products have become popular, but there is surprisingly little guidance on their use. We aimed to maximize the safety and efficacy of injectable PN by providing information on their pattern of practice among board‐certified dermatologists.MethodsA total of 235 Korean board‐certified dermatologists familiar with skin boosters participated in a survey which questioned the participant's years of practice, selection of skin boosters in one's clinic, and range of lasers and light sources as well as skin care devices that are available. For those who use PN, one was asked to check all its aesthetic indications, mode of delivery, injection depth, treatment interval as well as options for combined therapy.ResultsSeventy‐one percent of the survey participants had at least 5 years of professional experience as a board‐certified dermatologist, and among the different skin boosters, 88% replied that they practiced PN injection. The top six indications for PN were fine lines on the cheek followed by infraorbital fine lines, periorbital fine lines, uneven skin texture, dry skin, and fine lines on the forehead. Many opted for a 33G needle and the serial puncture technique targeting the dermis. A total of three sessions of PN injection spaced 4 weeks apart is most often recommended. 79 percent of PN users blended PN injection with lasers and light therapy with the most popular being radiofrequency (non‐invasive, needle RF) and high‐intensity focused ultrasound (HIFU).ConclusionPN is a skin booster which is widely practiced among Korean dermatologists. According to our survey, the best indication of PN is facial fine lines, and as such PN injection is often repeated and combined with a variety of non‐surgical rejuvenation procedures. We hope our data help dermatologists better understand and utilize PN injection.
Patients' and Nurses' experiences of caring in nursing: An integrative literature review across clinical practices
Authors: Hynnekleiv Ingerd Irgens , Jensen Jørghild K. , Giske Tove , Lausund Hilde , Mæland Elisabeth , Heggdal Kristin 
Published: December 2023

AbstractAimTo summarise, interpret and synthesize research findings on patients' and nurses' experiences of caring in nursing across clinical practices.BackgroundCaring is a universal element of nursing; however, economic restrictions often negatively impact health services, and time shortages and limited numbers of staff may characterize care encounters. It is unclear how these contextual conditions affect patients' and nurses' experiences of caring.Design and MethodsThis integrative literature review covers papers published between 2000 and 2022. Four databases—PubMed, PsycINFO (via Ovid), MEDLINE (via Ovid) and CINAHL (via EBSCO)—were systematically searched for eligible papers in May 2022. The included studies were critically appraised. Content analysis was performed to interpret and synthesize the findings. In accordance with the EQUATOR guidelines, the PRISMA 2020 and PRISMA‐S checklists were used. An Integrative review methodology guided the process.FindingsIn total, 33 studies were included in the review. Three themes captured the experiences of caring in nursing: (1) the complexity of the nursing care context, (2) the professionalism of the nurse, and (3) the trusting patient–nurse relationship.ConclusionThe experience of caring in nursing depended on nurses' competence and discretion in the personal encounter framed by the nursing context. The caring relationship was based on reciprocity, but it remains asymmetrical, as the nurse had the power and responsibility to empower the patient. Barriers, such as increased demands for efficiency and resource scarcity, may hinder the experience of caring in nursing.Implications for the profession and patient careBy promoting an ongoing discussion of caring in nursing, nurse management can systematically support nurses in reflecting on their practice in diverse and complex clinical contexts.Patient or public contributionNo patient or public contribution was made due to the study design.
RAD‐seq data provide new insights into biogeography, diversity anomaly, and species delimitation in eastern Asian–North American disjunct clade Benthamidia of Cornus (Cornaceae)
Authors: Du Zhi‐Yuan , Cheng Jin , Xiang Qiu‐Yun (Jenny) 
Published: December 2023

AbstractThe big‐bracted dogwood clade Benthamidia of Cornus is a typical example of the well‐known eastern Asia (EA) and North America (NA) floristic disjunction, with greater species diversity in EA than in NA. The lineage provides an opportunity to explore factors contributing to the plant diversity unevenness between EA and NA and test hypotheses on the origin of disjunct distribution from a phylogenetic perspective. We generated RAD‐seq data, conducted phylogenomic and biogeographic analyses for the clade with sampling of all species (9) and subspecies (10) currently recognized in floras. We also assessed species delineation and calculated phylogenetic diversity to evaluate the diversity unevenness between EA and NA. Finally, we examined variation of diversification rates and ecological niches on the phylogeny to explore potential causes underlying the observed diversity pattern. Our results revealed phylogenetic relationships congruent with previous studies and suggested a trans‐Beringian ancestral distribution of the clade Benthamidia in the mid‐Oligocene, dispersal from Mexico to eastern United States in the mid‐Miocene, and early diversification of the EA clade in SW China. Our results also confirmed greater phylogenetic diversity and diversification rate of the EA clade. Species delimitation analysis suggested 17 species in the clade Benthamidia, including all recognized subspecies. By integrating the results of molecular data with morphology, we proposed to retain the subspecies without changing their ranks. Our data suggested increased diversification rate in EA as an intrinsic factor explaining the greater species diversity in the region driven mainly by biogeographic isolation and partially by niche divergence.
Metabolic syndrome risk among adolescents in the Deep South and the relationships with behavioral health, food insecurity, and physical activity
Authors: Duck Angela A. , Karimi Masoumeh , Watkins LaDaryl L. , Tacy Joseph W. , Savell Christy L. , Hall Katherine C. 
Published: December 2023

AbstractPurposeA combination of physical and psychosocial risk factors put adolescents at risk for poor cardiometabolic health and chronic disease burden, often recognized as metabolic syndrome. The purposes of this study were to (1) identify the prevalence of metabolic syndrome risk among adolescents, utilizing the metabolic syndrome severity index, and (2) determine the relationship between metabolic syndrome risk and behavioral health, food insecurity, and physical inactivity among adolescents.Methods and DesignA cross‐sectional, descriptive, correlational design was deployed in an inner‐city high school in the Deep South. An 8‐month recruitment and enrollment period yielded a sample of 55 adolescents. A battery of measures included assessment of demographic data, anthropometric, cardiovascular, and psychosocial data. Utilizing these data elements, a progressive methodological approach was used to identify metabolic severity risk as a continuous variable for use in the adolescent population.ResultsAll participants identified as African American/Black. Among them, 71% (N = 39) were female and an average age of 16 (SD = 1.3) years old, with 67.3% (N = 37) of the sample at risk for metabolic syndrome. There was not a statistically significant relationship between metabolic syndrome severity score and behavioral health risk, food insecurity, and physical inactivity in this sample.Practice ImplicationsFuture use of the continuous metabolic syndrome severity score may guide practice by utilizing longitudinal data to assess the trends of metabolic syndrome severity scores in relation to disease outcomes in adolescents. This may promote the identification of psychosocial and physical interrelationships with metabolic syndrome, thus improving overall health through the development of age‐appropriate interventions.
Aquaculture practices in Bangladesh: A synopsis on prospects, productivity, and problems
Authors: Samanta Chandan Chironjib Singha , Roy Puja 
Published: December 2023

AbstractAquaculture is one of the most prominent sectors of Bangladesh regarding nutrition, livelihood, and revenues. Although this nation has made promising improvements in aquaculture, several existing and imminent challenges can disrupt further development. Until now, no studies have extensively reviewed the existing aquaculture practices of this nation. Thus, this article elucidates the prospects, production, and problems of common aquaculture practices for the establishment of sustainable aquaculture in Bangladesh. The culture units are mainly natural bodies of water including earthen ponds, seasonal floodplains, baor, and gher. Although pond farming is the oldest and most dominant practice in this nation, the use of pen and cage cultures has also been intensified in the last decade. Regarding farmed fish species, indigenous major carps, exotic carps, tilapia, pangas catfish, and climbing perch are the major runners. Among crustaceans, giant freshwater prawns and tiger shrimp are the leading farmed species. Mud crab, biofloc, and seaweed farming are a growing focus that can evolve as artisanal and commercial‐scale farming practices in the near future. Major challenges that are potent enough to impede the establishment of viable aquaculture practices in Bangladesh are inadequate seed production, disease outbreaks, climate change, mediocre management practices, and limited mariculture propagations.
Logoisk impact structure, Belarus: Shock transformation of zircon
Authors: Glazovskaya L. I. , Shcherbakov V. D. , Piryazev A. A. 
Published: December 2023

AbstractThe 17 km diameter, 30 Ma old Logoisk structure in Belarus (54°12′ N, 27°48′ E) was intensively drilled within the crater area. We summarize geological structure and petrologic information previously published mostly in Russian and describe shock deformation of zircon for the first time. The shock deformation features of zircon in the Logoisk suevite include the transition to reidite, the formation of planar fractures and granular textures, and the thermal decomposition to ZrO2 and SiO2. The presence of reidite in two grains in suevite was confirmed by micro‐Raman spectroscopy and EBSD (electron backscattered diffraction). Reidite was found in suevite glass of the Logoisk structure in grains containing zircon and in the ZrO2‐enriched rims on zircon. Granular zircon is commonly associated with ZrO2 and occurs as rims on zircon with interstitial impact melt, as dendritic rims, and in the inner parts of a zircon grain. A granular zircon from Logoisk represents the highest documented temperature of zircon transformation. The new data expands the knowledge of the P‐T conditions of formation of the Logoisk structure.
Analysis of layered boulders on asteroid (101955) Bennu and their implications for fluid flow on the parent body
Authors: Ishimaru K. , Lauretta D. S. 
Published: December 2023

AbstractThe observation of carbonate veins on asteroid Bennu supports the idea that large‐scale water flow may have occurred in carbonaceous asteroids in the early solar system. We identified and analyzed 11 boulders with layered structures on asteroid Bennu's surface using high‐resolution (centimeter‐scale) image and altimetry data obtained by the OSIRIS‐REx mission. The boulders' linear layer boundaries and parallel bedding follow the principle of original horizontality and suggest that they formed from sediment deposition by fluid flow on Bennu's parent body. We developed a simple model of the parent body (100‐km diameter with the density of CM chondrite material) and found that the water flow velocity had to be at least 21.1 cm s−1 to transport the largest clast observed embedded in a layered rock, which is 85 cm in average length. The flow velocity could have been as high as 26.5 cm s−1 if a larger clast observed on top of a layered rock was once embedded therein. Our results strongly support open‐system aqueous alteration on carbonaceous chondrite parent bodies.
Does planning to mixed feed undermine breastfeeding?
Authors: Michalopoulou Stamatia , Garcia Ada L. , Wolfson Linda , Wright Charlotte M. 
Published: December 2023

AbstractContinued breastfeeding is important for infants' health, but it is unclear whether mixed feeding increases the risk of breastfeeding cessation. We aimed to explore associations of mixed feeding and lactation problems with early cessation of breastfeeding. We analysed data from mothers who completed the Scottish National Maternal and Infant Feeding Survey and had previously breastfed their infants. At age 8–12 weeks, mothers (N = 1974) reported their feeding history and intentions, lactation problems and reasons for giving formula milk. The main outcome measure was cessation of breastfeeding before 6–8 weeks and time to cessation. By 6 weeks, 65% had mixed fed at some point, 32% had ceased breastfeeding, 22% were currently mixed feeding and 46% were exclusively breastfeeding. Lactation problems before 2 weeks were common (65%), and strongly associated with stopping breastfeeding (relative risk [RR]: 3.23, 95% confidence interval [CI]: 2.0–5.3) and with mixed feeding (RR: 3.14, 95% CI: 2.5–4.0). However, even after adjustment for breastfeeding problems mothers who planned to mixed feed (RR: 3.39, 95% CI: 2.4–4.9) and those who introduced formula for practicalities (RR: 3.21, 95% CI: 2.3–4.4) were more likely to stop breastfeeding. These variables also predicted later lactation insufficiency (planned mixed feeding RR: 1.39, 95% CI: 1.0–2.0; formula for practicalities RR: 1.76, 95% CI: 1.3–2.3). Mothers who received specialist lactation support were less likely to cease breastfeeding (RR: 0.63, 95% CI: 0.5–0.9) but nonspecialist input was unrelated to risk of cessation (RR: 1.06, 95% CI: 0.2–4.9). In conclusion, choosing to mix feed an infant is strongly associated with stopping breastfeeding, even in the absence of lactation problems.
Unilateral segmental presentation and a novel EPHB4 gene variant in capillary malformation–arteriovenous malformation type 2
Authors: Valente C. , Caldeira M. B. , Duarte B. , Batista J. , Cordeiro A. I. 
Published: December 2023

AbstractCapillary malformation–arteriovenous malformation is a rare autosomal dominant disorder associated with EPHB4 loss‐of‐function mutations. We report the unique presentation of a 6‐year‐old girl with multiple capillary malformations in a unilateral segmental distribution affecting the right hemiface, right upper chest, and right arm associated with overgrowth. Targeted next‐generation sequencing on a tissue sample revealed a novel heterozygotic variant in the EPHB4 gene (NM_004444.5 (EPHB4): c.715T>A, p.[Cys239Ser]). This case highlights a distinct presentation of CM‐AVM type 2 and showcases a new variant in EPHB4 not previously reported in the literature.
Early versus late onset interstitial lung disease in rheumatoid arthritis: An observational study of risk factors and mortality in Ontario, Canada
Authors: Fidler Lee , Widdifield Jessica , Fisher Jolene , Shapera Shane , Gershon Andrea S. 
Published: December 2023

AbstractBackground and ObjectiveInterstitial lung disease (ILD) can occur as a manifestation of rheumatoid arthritis (RA) at various times in the disease course. We aimed to identify factors associated with early versus late onset RA‐ILD and how the timing of RA‐ILD influenced surgical lung biopsy completion and mortality.MethodsWe performed a retrospective observational study using health services data from Ontario, Canada. We identified RA cases between 2000 and 2020 using the Ontario Rheumatoid Arthritis Database. RA‐ILD diagnosis required repeat physician visits for ILD, with early RA‐ILD defined as within 1 year of RA diagnosis. We performed multivariable logistic regression to identify factors associated with early RA‐ILD and surgical lung biopsy completion, and multivariable cox‐proportional hazards regression to evaluate the association of early versus late RA‐ILD on all‐cause and RA‐ILD related mortality.ResultsIn total, we identified 3717 cases of RA‐ILD. Older age at RA diagnosis [OR 1.04 (95%CI 1.03–1.05), p < 0.0001], female sex [OR 1.16 (95%CI 1.01–1.35), p = 0.04] and immigrating to Ontario [OR 1.70 (95%CI 1.35–2.14), p < 0.0001] was associated with early RA‐ILD. Patients with early versus late RA‐ILD experienced similar odds of undergoing a surgical lung biopsy [OR 1.34 (95%CI 0.83–2.16), p = 0.23]. Early RA‐ILD was associated with increased all‐cause mortality [HR 1.17 (95%CI 1.07–1.29), p = 0.0009], primarily driven by an increase in RA‐ILD related mortality [HR 1.45 (95%CI 1.19–1.76), p = 0.0003].ConclusionAge at RA onset, female sex and immigration status are associated with early RA‐ILD. Patients with early RA‐ILD experience increased all‐cause and RA‐ILD related mortality after adjusting for demographics and comorbidities.
Which indices of cardiorespiratory fitness are more strongly associated with brain health in children with overweight/obesity?
Authors: Haapala Eero A. , Lubans David R. , Jaakkola Timo , Barker Alan R. , Plaza‐Florido Abel , Gracia‐Marco Luis , Solis‐Urra Patricio , Cadenas‐Sanchez Cristina , Esteban‐Cornejo Irene , Ortega Francisco B. 
Published: December 2023

AbstractPurposeTo compare the strength of associations between different indices of cardiorespiratory fitness (CRF) and brain health outcomes in children with overweight/obesity.MethodsParticipants were 100 children aged 8–11 years. CRF was assessed using treadmill exercise test (peak oxygen uptake [V̇O2peak], treadmill time, and V̇O2 at ventilatory threshold) and 20‐metre shuttle run test (20mSRT, laps, running speed, estimated V̇O2peak using the equations by Léger et al., Mahar et al., and Matsuzaka et al.). Intelligence, executive functions, and academic performance were assessed using validated methods. Total gray matter and hippocampal volumes were assessed using structural MRI.ResultsV̇O2peak/body mass (β = 0.18, 95% CI = 0.01–0.35) and treadmill time (β = 0.18–0.21, 95% CI = 0.01–0.39) were positively associated with gray matter volume. 20mSRT laps were positively associated with executive functions (β = 0.255, 95% CI = 0.089–0.421) and academic performance (β = 0.199–0.255, 95% CI = 0.006–0.421), and the running speed was positively associated with executive functions (β = 0.203, 95% CI = 0.039–0.367). Estimated V̇O2peak/Léger et al. was positively associated with intelligence, executive functions, academic performance, and gray matter volume (β = 0.205–0.282, 95% CI = 0.013–0.500). Estimated V̇O2peak/Mahar et al. and V̇O2peak/Matsuzaka et al. (speed) were positively associated with executive functions (β = 0.204–0.256, 95% CI = 0.031–0.436).ConclusionAlthough V̇O2peak is considered the gold standard indicator of CRF in children, peak performance (laps or running speed) and estimated V̇O2peak/Léger et al. derived from 20mSRT had stronger and more consistent associations with brain health outcomes than other indices of CRF in children with overweight/obesity.
Efficacy and safety of a hydrocortisone aceponate‐containing ear spray solution in dogs with erythemato‐ceruminous otitis externa: A randomised, multicentric, single‐blinded, controlled trial
Authors: Rigaut Delphine , Briantais Philippe , Jasmin Pierre , Bidaud Alice 
Published: December 2023

AbstractBackgroundErythemato‐ceruminous otitis externa (ECOE) is frequently seen in dogs affected with an allergic skin disease, with recurrent secondary bacteria and yeast overgrowths (detected on cytological examination).ObjectivesThe objective of the study was to compare the efficacy and safety of an ear spray containing only hydrocortisone aceponate glucocorticoid diester (HCA) to a control product (CTRL), an approved otic formulation containing prednisolone‐miconazole‐polymyxin combination, in dogs with ECOE.AnimalsIn total, 97 and 104 dogs with ECOE were respectively randomly assigned to the tested ear treatment product group (HCA) or the commercially available ear treatment control product group (CTRL).Materials and MethodsDogs were treated for 7–14 days, as needed. At Day (D)0, D7, D14, D28 and D42, Otitis Index Score‐3, hearing test, pruritus and pain visual analogue scales, and cytological scores were graded. The overall response to treatment also was assessed.ResultsAll clinical parameters decreased rapidly and in a similar way without any significant difference at any time between treatment groups. A good‐to‐excellent response to treatment was seen in >90% of dogs of both groups as early as D14. The treatment was considered safe in all dogs.Conclusions and Clinical RelevanceA 7‐ to 14‐day ear topical application of HCA alone to dogs with ECOE accompanied with bacterial and/or fungal (yeast) overgrowth was safe and led to no statistical difference in improvement of clinical scores relative to the CTRL combination. Based on these results, it may be necessary to reconsider the routine use of antimicrobial drugs such as antibiotics and antifungals as a first‐line treatment for ECOE that is likely to have been caused by an allergic reaction.
Targeted genetic therapies for inherited disorders that affect both cardiac and skeletal muscle
Authors: Psaras Yiangos , Toepfer Christopher N. 
Published: December 2023

AbstractSkeletal myopathies and ataxias with secondary cardiac involvement are complex, progressive and debilitating conditions. As life expectancy increases across these conditions, cardiac involvement often becomes more prominent. This highlights the need for targeted therapies that address these evolving cardiac pathologies. Musculopathies by and large lack cures that directly target the genetic basis of the diseases; however, as our understanding of the genetic causes of these conditions has evolved, it has become tractable to develop targeted therapies using biologics, to design precision approaches to target the primary genetic causes of these varied diseases. Using the examples of Duchenne muscular dystrophy, Friedreich ataxia and Pompe disease, we discuss how the genetic causes of such diseases derail diverse homeostatic, energetic and signalling pathways, which span multiple cellular systems in varied tissues across the body. We outline existing therapeutics and treatments in the context of emerging novel genetic approaches. We discuss the hurdles that the field must overcome to deliver targeted therapies across the many tissue types affected in primary myopathies.
Draft genome sequence of
Thermococcus waiotapuensis
WT1
T
, a thermophilic sulfur-dependent archaeon from the order
Thermococcales
Authors: Manners Sarah H. , Carere Carlo R. , Dhami Manpreet K. , Dobson Renwick C. J. , Stott Matthew B. 
Published: December 2023

ABSTRACT

Thermococcus waiotapuensis
WT1
T
is a thermophilic, peptide, and amino acid-fermenting archaeon from the order
Thermococcales
. It was isolated from Waiotapu, Aotearoa-New Zealand, and has a genome size of 1.80 Mbp. The genome contains 2,000 total genes, of which 1,913 encode proteins and 46 encode tRNA.