bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Insulin Secretion in the Turner Metabolic Syndrome
Authors: Bakalov Vladimir K. , Cooley Margaret M. , Quon Michael J. , Luo Mei Lin , Yanovski Jack A. , Nelson Lawrence M. , Sullivan Gail , Bondy Carolyn A. 
Published: July 2004

Abstract
An increased prevalence of impaired glucose homeostasis (IGH) and diabetes mellitus is reported in monosomy X, or Turner syndrome (TS). To determine whether IGH is an intrinsic feature of this syndrome, independent of obesity or hypogonadism, we compared results of a standard oral glucose challenge in age- and body mass index-matched women with TS and with karyotypically normal premature ovarian failure (POF). Fasting glucose levels were normal in both groups, but glucose values after oral glucose challenge were higher in TS [2-h glucose, 135 ± 36 mg/dl (7.5 ± 2.0 mmol/liter) in TS and 97 ± 18 mg/dl (5.4 ± 1.0 mmol/liter) in POF; P &lt; 0.0001]. Glucose-stimulated insulin secretion was lower in TS; e.g. the initial insulin response (ΔI/ΔG30) was decreased by 60% compared with POF (P &lt; 0.0001). We also compared responses to a standard iv glucose tolerance test in women with TS and in age- and body mass index-matched normal women and found that the insulin area under the curve was 50% lower in women with TS (P = 0.003). Insulin sensitivity measured by the quantitative insulin sensitivity check index was higher in women with TS compared with both control groups. Thus, IGH is not secondary to obesity or hypogonadism in TS, but it is a distinct entity characterized by decreased insulin secretion, suggesting that haploinsufficiency for X-chromosome gene(s) impairs β-cell function and predisposes to diabetes mellitus in TS.
Comparing Direct Thrombin Inhibitors Using aPTT, Ecarin Clotting Times, and Thrombin Inhibitor Management Testing
Authors: Gosselin Robert C , King Jeffrey H , Janatpour Kim A , Dager William E , Larkin Edward C , Owings John T 
Published: July 2004

BACKGROUND: Patients with heparin-induced thrombocytopenia and thrombosis may be acutely anticoagulated with direct thrombin inhibitors (DTIs). The anticoagulation is typically monitored using the activated partial thromboplastin time (aPTT) or ecarin clotting time (ECT). OBJECTIVE: To compare 14 methods for measuring aPTT, as well as ECT and thrombin inhibitor management test (TIM), in samples containing DTIs. METHODS: DTIs were added to pooled normal plasma to achieve low (0.1–1.2 μg/mL) and high (1.5–8.0 μg/mL) drug concentrations. Each low-concentration DTI sample was tested using all aPTT reagents, while each low- and high-concentration DTI was tested using the ECT and TIM. RESULTS: All aPTT reagents had a significant dose-dependent correlation with drug concentration. Only Actin FSL and APTT-S demonstrated equivalent aPTT ratios obtained from any DTI. The TAS-aPTT was the most sensitive aPTT reagent to argatroban, with the aPTT ranging from 52.7 to 121.2 seconds corresponding to 0.1 to 1.2 μg/mL of drug concentration. The TAS-aPTT and Pathromtin were the most sensitive aPTT reagents to bivalirudin, with aPTTs of 87.4 seconds and 101.5 seconds, respectively, at 1.2 μg/mL of drug. Pathromtin was the most sensitive aPTT reagent to lepirudin, with a maximum aPTT of 108.9 seconds at 1.2 μg/mL of drug. There was no statistically significant difference between the TIM and ECT clotting times for each DTI. Lepirudin and bivalirudin ECT and TIM clotting times were equivalent. CONCLUSIONS: There are unique differences between reagent manufacturers in the monitoring of DTIs. Acceptable alternatives to aPTT monitoring of DTI anticoagulation include the ECT and TIM.
Self-Reported Morisky Score for Identifying Nonadherence with Cardiovascular Medications
Authors: Shalansky Stephen J , Levy Adrian R , Ignaszewski Andrew P 
Published: July 2004

BACKGROUND: The Morisky medication adherence scale is a commonly used adherence screening tool. It is composed of 4 yes/no questions about past medication use patterns and is thus quick and simple to use during drug history interviews. OBJECTIVE: To evaluate the use of the self-reported Morisky score as a screening tool for identifying patients who have been nonadherent with chronic cardiovascular medications. METHODS: Patients who had taken an angiotensin-converting enzyme inhibitor or lipid-lowering agent for at least 3 consecutive months were interviewed using a structured questionnaire including the Morisky scale. Nonadherence was defined as taking <80% of chronic cardiovascular medications based on prescription refill data over the previous 14 months. RESULTS: Forty-nine of 377 (13%) patients were categorized as nonadherent; however, only 12 (3%) patients had Morisky scores suggesting a high likelihood of nonadherence (3 or 4). While the Morisky score was a significant independent predictor of nonadherence by multivariate analysis, there was no threshold score or individual question that yielded concurrent high sensitivity and positive predictive values (PPVs) for identifying nonadherent patients. The internal consistency of the questions was low (α 0.32), as were item-to-total score correlations, suggesting that the individual questions were not measuring the same attribute. CONCLUSIONS: Using the Morisky scale to identify patients who have been nonadherent with chronic cardiovascular medications may be reasonable in some settings; however, the threshold score would have to be chosen based on a trade-off between sensitivity and PPV. These results were likely influenced by the low rate of nonadherence in this cohort. Rewording the questions, increasing the number of questions, and the use of graded response options may improve consistency.
Erythropoietin and Erythropoietin Receptor: History, Structure, Interactions, and Intracellular Signal Transduction
Authors: Ghaffari Saghi , Constantinescu Stefan N. 
Published: July 2004

AbstractErythropoietin (Epo) is essential for formation of red blood cells. Recombinant Epo has been improving life of thousands of patients with anemia such as renal patients around the world. More recently, it has become clear that Epo may also regulate the behavior of other cell types such as neuronal cells, where Epo exerts an antiapoptotic effect. Understanding the modality of action of Epo in erythroid cells will help in characterizing the role of Epo in other cell types where Epo‐receptor (EpoR) is expressed.
Giant omphalocele and “prune belly” sequence as components of the Beckwith–Wiedemann syndrome
Authors: Sinico Martine , Touboul Claudine , Haddad Bassam , Encha‐Razavi Féréchté , Paniel Jean‐Bernard , Gicquel Christine , Gérard‐Blanluet Marion 
Published: July 2004

AbstractWe report a case of severe Beckwith–Wiedemann syndrome (BWS) in a fetus at 16 weeks of gestation. This presentation, incompatible with life, included a giant omphalocele and absence of abdominal wall musculature with extremely dilated bladder, as in the “prune belly” sequence. Adrenal cytomegaly pointed to BWS. Molecular analysis confirmed the diagnosis of BWS and showed an isolated demethylation of the KCNQ1OT1 gene. This report demonstrates that lethal fetal abdominal wall defects associated with adrenal cytomegaly are linked to epigenetic change of the 11p15 imprinted region. © 2004 Wiley‐Liss, Inc.
A de novo complex karyotype with two independent balanced translocations and a double inversion of chromosome 6 presenting with multiple congenital anomalies
Authors: Kline Antonie D. , Griffin Constance A. , Haddadin Mary H. , Chudoba Ilse , Morsberger Laura A. , Hawkins Anita L. , Amato R. Stephen , Munshi Gaurang , Cohen Maimon M. 
Published: July 2004

AbstractWe report a 4‐year‐old female with a de novo complex karyotype with multiple chromosomal rearrangements and a distinctive phenotype. Her medical history is significant for having been a twin born at 35 weeks gestation, breech presentation, with feeding problems and poor growth as an infant, gastroesophageal reflux disease, peripheral pulmonic stenosis, omphalocele, high myopia, and severe mental retardation. She is small for her age with microcephaly, posteriorly sloping forehead, shallow orbits, long palpebral fissures, prominent nose, wide mouth, absent uvula, kyphosis, brachydactyly, bridged palmar crease, and hypertonia. Peripheral blood lymphocytes revealed a karyotype of 46,XX,t(1;12)(p22.3;q21.3),inv(6)(p24q23),t(7;18)(q11.2;q21.2) in all cells. Parental karyotypes and that of her twin were normal. Spectral Karyotyping™ (SKY) and fluorescence in situ hybridization (FISH) with whole chromosome paints for chromosomes 1, 6, 7, 12, and 18 did not reveal additional rearrangements. Prometaphase G‐banding analysis suggested that the “inverted” chromosome 6 might contain a cryptic rearrangement. Although no deletion nor duplication was detected using metaphase comparative genomic hybridization (CGH), multicolor high resolution banding (mBAND) demonstrated a double inversion of chromosome 6, resulting in a final karyotype as above but including der(6)(pter → p23::q21 → q22.3::q21 → p23::q22.3 → qter). © 2004 Wiley‐Liss, Inc.
Renal defects and limb deficiencies in 197 infants: Is it possible to define the “acrorenal syndrome”?
Authors: Kroes Hester Y. , Olney Richard S. , Rosano Aldo , Liu Yecai , Castilla Eduardo E. , Cocchi Guido , De Vigan Catherine , Martínez‐Frías María L. , Mastroiacovo Pierpaolo , Merlob Paul , Mutchinick Osvaldo , Ritvanen Annukka , Stoll Claude , van Essen Anthonie J. , Cobben Jan Maarten , Cornel Martina C. 
Published: July 2004

AbstractDieker and Opitz in 1969 described the simultaneous occurrence of limb deficiencies (LDs) and renal anomalies (RAs) in three patients. Curran and Curran introduced in 1972 the term “acrorenal syndrome.” Since then, the term “acrorenal syndrome” is used occasionally, but a well‐circumscribed definition has never been established. On the other hand, the concept of an acrorenal polytopic developmental field defect was postulated by Opitz and others to explain the association between RAs and LDs. We undertook this study to investigate whether this acrorenal “syndrome” could be identified in a large group of cases with congenital RAs and a limb deficiency. Eleven birth defect registries that are part of the International Clearinghouse for Birth Defects Monitoring (i.e., registries of ICBDMS in Finland, France [Paris and Strasbourg], Israel, Italy [IPIMC and Emilia Romagna], Mexico, Northern Netherlands, South America, Spain, and the United States [Atlanta]) provided data on 815 infants who had a LD and at least one other major congenital anomaly. These 815 cases were ascertained among 5,163,958 births. We selected the 197 cases who had both a limb deficiency and a renal or urinary tract anomaly. In about 50% of these cases a diagnosis or a recognized phenotype was reported, with chromosomal aberrations and VACTERL being most frequent. In the group with no diagnosis or recognized phenotype (95 cases), we looked for (a) clustering of specific types of LDs and RAs, and (b) for clustering of associated anomalies, in order to find evidence for and be able to define better the term “acrorenal syndrome.” Our data suggest that an association exists between LDs and RAs, possibly explained by the concept of the acrorenal polytopic developmental field defect. However, our dataset does not yield evidence for the existence of one distinct “syndrome,” defined as a pattern of causally related multiple anomalies. Therefore, use of the term “acrorenal syndrome” should be avoided. © 2004 Wiley‐Liss, Inc.
Synthesis and Cytostatic Properties of Some 6H‐Indolo[2, 3‐b][1, 8]naphthyridine Derivatives
Authors: Mastalarz Henryk , Jasztold‐Howorko Ryszard , Rulko Felicja , Croisy Alain , Carrez Daniele 
Published: July 2004

AbstractThe new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2‐chloro‐1, 8‐naphthyridines. The synthesized 6H‐indolo[2, 3‐b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
Prognosen bei Beobachtungsmethoden
Authors: Gudehus Gerd 
Published: July 2004

AbstractDie Beobachtungsmethode nach Peck und diejenige der neuen DIN 1054 setzen übliche geotechnische Prognosen voraus. Die kurz vorgestellte Hypoplastizität ermöglicht Prognosen in einem weiteren Anwendungsbereich. Dies wird von Beispielen Pecks ausgehend konkretisiert und diskutiert. Dabei kommen eingeschränkte Duktilität und verzögerter Kriechbruch zur Sprache. Varianten der Beobachtungsmethode werden dargelegt, am Schluß auch eine mit Hypoplastizität.
Empfehlung Nr. 2 des Arbeitskreises “Geotechnik historischer Bauwerke und Naturdenkmäler” der DGGT: Baugrundbedingte Risse und Verformungen an historischen Bauwerken
Authors: Smoltczyk Ulrich 
Published: July 2004

AbstractDer Arbeitskreis “Geotechnik historischer Bauwerke und Naturdenkmäler” der Deutschen Gesellschaft für Geotechnik e.V. erarbeitet Empfehlungen für das Vorgehen beim Auftreten von Schäden an historischen Bauwerken, die auf Effekte im Untergrund bzw. Gründungsbereich zurückzuführen sind.
RECP: A Reactor Designed to Test the Effect of a Catalyst on Soot Oxidation in a Diesel Particulate Filter
Authors: Nguyen Huu Nhon Y. , Brilhac J.‐F. , Petit C. 
Published: July 2004

AbstractA new reactor designed to test soot combustion on a filter coated with an oxidation catalyst is described. It is designed to achieve screening investigations of catalysts in realistic conditions, i.e., close to those prevailing in a diesel particulate filter (DPF). In a DPF a soot layer is formed at the surface of a porous wall (filtration area) which may or may not be covered with a catalytic layer. In this new setup, the soot is deposited on a sample of a DPF which can be easily impregnated with oxidation catalysts. A model soot (commercial carbon black) is used for the investigation, and different procedures for the soot &#132;deposit on the filter are tested.
Translation of MAT Kinetic Data to Model Industrial Catalytic Cracking Units
Authors: Maya‐Yescas R. , León‐Becerril E. , Salazar‐Sotelo D. 
Published: July 2004

AbstractBench‐ and laboratory‐scale reactors are required to infer kinetic data for catalytic cracking units. One of the most common methods is the microactivity test (MAT, ASTM D‐3902–92), that emulates the catalyst‐to‐oil ratio using a fixed‐bed reactor and a semibatch accumulator of liquids. Translation of data obtained from MAT tests in order to infer kinetic parameters to model continuous industrial units is, consequently, difficult and uncertain. In this work, the extraction of kinetic data obtained in a MAT reactor is analyzed. Estimation of a kinetic rate equation to evaluate instantaneous conversion in MAT reactors is performed. The activation energy obtained is kinetic and can be used during the modeling of riser reactors. It was possible, also, to infer values of the remaining catalytic activity after each experiment; these values were used to adjust a hyperbolic deactivation function, useful to model industrial riser reactors.
Gas Cleaning Systems of Decentralized Hazardous Waste Incinerators in the Chemical Industry
Authors: Lehner M. , Hoffmann A. 
Published: July 2004

AbstractGaseous and/or liquid residues of chemical production processes are frequently disposed of in comparatively small hazardous waste incinerators directly on‐site. With respect to the extremely high pollutant emissions, multistage wet gas cleaning processes are used that consist in most cases of a quench, one or more wet scrubbers and an optional aerosol separation stage. In order to select a suitable design of the gas cleaning process and equipment, besides the specific technical performance of each apparatus, particularly economic criteria have to be considered, like maintenance as well as investment costs. Additionally, the choice of the suitable material of construction plays a major role, especially at the transition section of dry to wetted gas in the quench. The paper compares qualitatively or quantitatively different equipment and process alternatives towards their performance. The present comparison indicates that only the consideration of all relevant parameters yields an optimal solution.
Dissociation Potential Curves of Low‐Lying States in Transition Metal Hydrides. Part 2. Hydrides of Groups 3 and 5
Authors: Koseki Shiro , Ishihara Yohei , Fedorov Dmitri G. , Umeda Hiroaki , Schmidt Michael W. , Gordon Mark S. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Infrared Signature of Structures Associated with the H+(H2O)n (n = 6 to 27) Clusters.
Authors: Shin J.‐W. , Hammer N. I. , Diken E. G. , Johnson M. A. , Walters R. S. , Jaeger T. D. , Duncan M. A. , Christie R. A. , Jordan K. D. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Comparison of the Crystal Structures of the Tetraammoniates of Lithium Halides, LiBr×4NH3 and LiI×4NH3, with the Structure of Tetramethylammonium Iodide, N(CH3)4I.
Authors: Jacobs Herbert , Barlage Holger , Friedriszik Martin 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantiomerically Pure Amines as Substrates for the Ti‐Catalyzed Hydroamination of Alkynes.
Authors: Pohlki Frauke , Bytschkov Igor , Siebeneicher Holger , Heutling Andreas , Koenig Wilfried A. , Doye Sven 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of (E,Z)‐3‐Chloro‐2‐propenamides, Acids, and Esters from 2,3‐Acetylenic Acids with Oxalyl Chloride in DMF.
Authors: Urdaneta Neudo A. , Salazar Jose , Herrera Julio C. , Lopez Simon E. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Aerobic Oxidation of Cycloalkanes, Alcohols and Ethylbenzene Catalyzed by the Novel Carbon Radical Chain Promoter NHS (N‐Hydroxysaccharin).
Authors: Baucherel Xavier , Gonsalvi Luca , Arends Isabel W. C. E. , Ellwood Simon , Sheldon Roger A. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pd/C‐Catalyzed Transfer‐Hydrogenation of Benzaldehydes to Benzyl Alcohols Using Potassium Formate as the Selective Hydrogen Donor.
Authors: Baidossi Mubeen , Joshi Ashutosh V. , Mukhopadhyay Sudip , Sasson Yoel 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Zirconium(IV) Chloride Catalyzed Ring Opening of Epoxides with Aromatic Amines.
Authors: Swamy N. Raghavendra , Goud T. Venkateshwar , Reddy S. Malla , Krishnaiah P. , Venkateswarlu Y. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel and Highly Selective Conversion of Alcohols, Thiols, and Silyl Ethers to Azides Using the Triphenylphosphine/2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ)/n‐Bu4NN3 System.
Authors: Iranpoor Nasser , Firouzabadi Habib , Akhlaghinia Batool , Nowrouzi Najmeh 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereoselective Preparation of Conjugated E‐Enynes from E‐Vinylic Tellurides and Terminal Alkynes via Sonogashira Cross‐Coupling.
Authors: Zeni Gilson , Alves Diego , Pena Jesus M. , Braga Antonio L. , Stefani Helio A. , Nogueira Cristina W. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sulfamic Acid as a Cost‐Effective and Recyclable Catalyst for Liquid Beckmann Rearrangement, a Green Process to Produce Amides from Ketoximes Without Waste.
Authors: Wang Bo , Gu Yanlong , Luo Cheng , Yang Tao , Yang Liming , Suo Jishuan 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Zirconium(IV) Chloride as a New, Highly Efficient, and Reusable Catalyst for Acetylation of Phenols, Thiols, Amines, and Alcohols under Solvent‐Free Conditions
Authors: Chakraborti Asit K. , Gulhane Rajesh 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ru(II)‐Catalyzed Chemo‐ and Regioselective Cyclotrimerization of Three Unsymmetrical Alkynes Through Boron Temporary Tether. One‐Pot Four‐Component Coupling via Cyclotrimerization/Suzuki—Miyaura Coupling.
Authors: Yamamoto Yoshihiko , Ishii Jun‐ichi , Nishiyama Hisao , Itoh Kenji 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of Cycloalkenyl and Alkenyloxiranes from Allylic Sulfoximines and Aldehydes and Application to Solid‐Phase Synthesis.
Authors: Gais Hans‐Joachim , Babu Gadamsetti S. , Guenter Markus , Das Parthasarathi 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enzymatic Resolution of 5‐Phenylselanyltetrahydro‐2‐furanone. Enantioselective Preparation of (R)‐ and (S)‐γ‐Valerolactone.
Authors: Clososki Giuliano C. , Costa Carlos E. , Missio Lauri J. , Cass Quezia B. , Comasseto Joao V. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sulfonamido, Azidosulfonyl and N‐Acetylsulfonamido Analogues of Rofecoxib: 4‐[4‐(N‐Acetylsulfonamido)phenyl] ‐3‐(4‐methanesulfonylphenyl)‐2(5H)furanone is a Potent and Selective Cyclooxygenase‐2 Inhibitor.
Authors: Zarghi Afshin , Rao P. N. Praveen , Knaus Edward E. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Practical Two‐Step Synthesis of 3‐Alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones.
Authors: Ruan Yuan‐Ping , Chen Ming‐De , He Ming‐Zhu , Zhou Xiang , Huang Pei‐Qiang 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crude D‐(+)‐Glyceraldehyde Obtained from D‐Mannitol‐Diacetonide by Oxidative Cleavage with Sodium Periodate: Its Reactions with Nucleophilic Species.
Authors: de O. Domingos Jorge L. , de A. Vilela Guilherme V. M. , Costa Paulo R. R. , Dias Ayres G. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Umpolung of the 5‐Alkyl‐2‐dimethylamino‐1,3‐dithiolium‐4‐thiolate Mesoion and Its Application in the Synthesis of Some New Tetrathiafulvalenes.
Authors: Hellberg Jonas , Dahlstedt Emma , Woldegiorgis Andreas 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3,4,5,6‐Tetrahydro‐2H‐1,3,4‐oxadiazin‐2‐ones Employing a Metal Hydride and Diethyl Carbonate: An Alternative Cyclization Method over 1,1′‐Carbonyldiimidazole.
Authors: Casper David M. , Kieser David , Blackburn Jennifer R. , Hitchcock Shawn R. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Structure—Activity Relationships of Untenone A and Its Derivatives for Inhibition of DNA Polymerases.
Authors: Saito Fumiyo , Takeuchi Ryo , Kamino Tomoyuki , Kuramochi Kouji , Sugawara Fumio , Sakaguchi Kengo , Kobayashi Susumu 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Series of Estrogen Receptor Modulators: Effect of Alkyl Substituents on Receptor‐Binding Affinity.
Authors: Kamada Atsushi , Sasaki Atsushi , Kitazawa Noritaka , Okabe Tadashi , Nara Kazumasa , Hamaoka Shinichi , Araki Shin , Hagiwara Hiroaki 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Neutron Scattering Studies of Nanomagnetism and Artificially Structured Materials
Authors: Fitzsimmons M. R. , Bader S. D. , Borchers J. A. , Felcher G. P. , Furdyna J. K. , Hoffmann A. , Kortright J. B. , Schuller Ivan K. , Schulthess T. C. , Sinha S. K. , et al. et al. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.