bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education can reassure people with rotator cuff–related shoulder pain: a 3-arm, randomised, online experiment
Authors: Zadro Joshua R. , Ferreira Giovanni E. , Muller Ryan , Sousa Filho Luis Fernando , Malliaras Peter , West Courtney A. , O'Keeffe Mary , Maher Christopher G. 
Published: December 2023

Abstract
We aimed to investigate the immediate effect of best practice education (with and without pain science messages) and structure-focused education on reassurance among people with rotator cuff–related shoulder pain. We conducted a 3-arm, parallel-group, randomised experiment. People with rotator cuff–related shoulder pain were randomised (1:1:1) to (1) best practice education (highlights that most shoulder pain is not serious or a good indicator of tissue damage and recommends simple self-management strategies); (2) best practice education plus pain science messages (which attempt to improve understanding of pain); and (3) structure-focused education (highlighting that structural changes are responsible for pain and should be targeted with treatment). Coprimary outcomes were self-reported reassurance that no serious condition is causing their pain and continuing with daily activities is safe. Secondary outcomes measured management intentions, credibility and relevance of the education, and similarity to previous education. Two thousand two hundred thirty-seven participants were randomised and provided primary outcome data. Best practice education increased reassurance that no serious condition is causing their pain (estimated mean effect 0.5 on a 0-10 scale, 95% confidence interval [CI] 0.2-0.7) and continuing with daily activities is safe (0.6, 95% CI 0.3-0.8) compared with structure-focused education. Adding pain science messages to best practice education slightly increased both measures of reassurance (0.2, 95% CI 0.0-0.4). Clinicians treating patients with rotator cuff–related shoulder pain should highlight that most shoulder pain is not serious or a good indicator of tissue damage and recommend simple self-management strategies. The benefit of adding pain science messages is small.
Updated recommendations on measures for clinical trials in pediatric chronic pain: a multiphase approach from the Core Outcomes in Pediatric Persistent Pain (Core-OPPP) Workgroup
Authors: Palermo Tonya M. , Li Rui , Birnie Kathryn A. , Crombez Geert , Eccleston Christopher , Kashikar-Zuck Susmita , Stone Amanda L. , Walco Gary A. 
Published: December 2023

AbstractMany gaps remain in finding effective, safe, and equitable treatments for children and adolescents with chronic pain and in accessing treatments in different settings. A major goal of the field is to improve assessment of pain and related experience. Valid and reliable patient-reported outcome measures are critical for advancing knowledge of clinical interventions for pediatric chronic pain. Building on the work of the Ped-IMMPACT group, we previously updated a core outcome set (COS) for pediatric chronic pain clinical trials using stakeholder feedback from providers, youth, and parents. The new COS includes 3 mandatory domains: pain severity, pain-related interference with daily living, and adverse events and 4 optional domains: overall well-being, emotional functioning, physical functioning, and sleep quality. The aim of this study was to use a multiphased approach to recommend specific measures for each of the 7 domains identified in our new COS for pediatric chronic pain. We synthesized evidence through conducting the following: (1) a Delphi study of experts to identify candidate measures for the new COS domains, (2) a review phase to gather evidence for measurement properties for candidate measures, and (3) an expert consensus conference to reach agreement on measurement recommendations. Final recommendations included 9 patient-reported measures. Important contextual considerations are discussed, and guidance is provided regarding strengths and limitations of the recommendations. Implementation of these recommendations may be enhanced by widespread dissemination and ease of access to measurement tools.
Giant pilomatricoma with coexisting angiomyxoid stroma histopathology: a case report
Authors: Mazzarella Francesca , Del Forno Biancamaria , Caporali Enrico , Costa Alfio Luca , Vindigni Vincenzo , Bassetto Franco , Brambullo Tito 
Published: December 2023

Introduction:
Pilomatricoma, also known as benign calcifying epithelioma of Malherbe, is a follicular tumor originating from cells in the hair follicle matrix. It usually manifests as a firm subcutaneous mass up to 3 cm in size. Less commonly, it may measure >5 cm and in such cases is called giant pilomatricoma.
We herein present a case of a subcutaneous lesion that was characterized by aggressive biological behavior and initially thought to be malignant but subsequently found to be a rare angiomyxoid variant of giant pilomatricoma.

Case presentation:
This case involved a young, healthy woman with a rapidly growing subcutaneous lesion on the distal lateral side of her right arm. An incisional biopsy was performed, and the lesion was diagnosed as hyperplasia of the epidermis and subcutaneous tissue, likely of reactive nature. After radical excision, analysis of the entire specimen led the pathologist to diagnose a rare variant of giant pilomatricoma with angiomyxoid stroma.

Discussion:
Classic pilomatricoma is an indolent, slow-growing lesion that is well defined and not fixed to the underlying tissue planes. However, after showing no signs of enlargement for 6 months, the lesion in the present case began to grow in a very unusual and concerning manner, suggesting a skin malignancy. The patient’s young age and the rapid development and large dimensions of the lesion led us to suspect a sarcoma.

Conclusion:
This case highlights the importance of cooperation between the dermatosurgeon and the pathologist to ensure thorough evaluation of such misleading cases. Such cooperation will guide appropriate management decisions and avoid overtreatment of benign lesions.
Characteristics of Canadians living with long-term health conditions or disabilities who had unmet rehabilitation needs during the first wave of the COVID-19 pandemic: A cross-sectional study
Authors: DeSouza Astrid , Wang Dan , Wong Jessica J. , Furlan Andrea D. , Hogg-Johnson Sheilah , Macedo Luciana , Mior Silvano , Côté Pierre 
Published: December 2023

ABSTRACT

Objective
To describe the characteristics associated with unmet rehabilitation needs in a sample of Canadians with long-term health conditions or disabilities during the first wave of the COVID-19 pandemic.

Design
Data from the Impacts of COVID-19 on Canadians – Living with Long-Term Conditions and Disabilities, a national cross-sectional survey with 13,487 respondents. Unmet needs were defined as needing rehabilitation (i.e., physiotherapy/massage/chiropractic, speech therapy, occupational therapy, counselling services, or support groups) but not receiving due to the pandemic. We used multivariable modified Poisson regression to examine the association between demographic, socioeconomic, and health-related characteristics, and unmet rehabilitation needs.

Results
More than half of the sample were ≥ 50 years (52.3%), female (53.8%), and 49.3% reported unmet rehabilitation needs. Those more likely to report unmet needs were females, those with lower socio-economic status (receiving disability benefits or social assistance, job loss, increased work hours, decreased household income or earnings), and those with lower perceived general health or mental health status.

Conclusions
Among Canadians with disabilities or chronic health conditions, marginalized groups are more likely to report unmet rehabilitation needs. Understanding the systemic and upstream determinants is necessary to develop strategies to minimize unmet rehabilitation needs and facilitate the delivery of equitable rehabilitation services.
Protocol to evaluate the efficacy and safety of tolvaptan in patients with refractory ascites after liver resection: an open-label, single-arm phase I/II study
Authors: Namba Yosuke , Kobayashi Tsuyoshi , Kuroda Shintaro , Hashimoto Masakazu , Takei Daisuke , Fukuhara Sotaro , Oshita Ko , Matsubara Keiso , Honmyo Naruhiko , Nakano Ryosuke , Sakai Hiroshi , Tahara Hiroyuki , Ohira Masahiro , Ide Kentaro , Ohdan Hideki 
Published: December 2023

Background:
In patients with chronic liver diseases such as cirrhosis, massive ascites after hepatic resection is the cause of prolonged hospitalization and worsening prognosis. Recently, the efficacy of tolvaptan in refractory ascites has been reported; however, there are no reports on the efficacy or safety of tolvaptan for refractory ascites after hepatic resection. This study aims to evaluate the efficacy of early administration of tolvaptan in patients with refractory ascites after hepatic resection.

Materials and methods:
This is an open-label, single-arm phase I/II study. This study subject will comprise patients scheduled for hepatic resection of a liver tumor. Patients with refractory ascites after hepatic resection (drainage volume on postoperative day 1 ≥5 ml/body weight 1 kg/day) will be treated with tolvaptan. The primary endpoint will include the maximum change in body weight after hepatic resection relative to the preoperative baseline. The secondary endpoints will include drainage volume, abdominal circumference, urine output, postoperative complication rate (heart failure and respiratory failure), number of days required for postoperative weight gain because of ascites to decrease to preoperative weight, change in improvement of postoperative pleural effusion, total amount of albumin or fresh frozen plasma transfusion, type and amount of diuretics used, and postoperative hospitalization days.

Conclusion:
This trial will evaluate the efficacy and safety of tolvaptan prophylaxis for refractory ascites after hepatic resection. As there are no reports demonstrating the efficacy of tolvaptan prophylaxis for refractory ascites after hepatic resection, the authors expect that these findings will lead to future phase III trials and provide valuable indications for the selection of treatments for refractory postoperative ascites.
The Variation of Chargemaster Price Listings for Urogynecologic Procedures
Authors: Baban Saman , Kasoff Madison , Kadesh Amanda , Chaudhary Richard , Lui Aiden , Shi Jeanne , Ahluwalia Jai , White Michael , Giles Dobie , Petersen Timothy R. , Andiman Sarah , Grimes Cara L. 
Published: December 2023

Importance
A 2018 Executive Order calling for price transparency required hospitals to publicly provide chargemasters, which are detailed lists of standard price listings for billable medical procedures.

Objectives
The objective of this study was to evaluate price listing variations in common urogynecology procedures.

Study Design
This was a cross-sectional study of chargemasters obtained between February and April 2020 from hospitals across 5 states chosen to reflect the diversity of health systems in the United States. Hospital characteristic and quality metric data were obtained from the Homeland Infrastructure Foundation, U.S. Department of Agriculture, and U.S. Centers for Medicare & Medicaid Services websites. Current Procedural Terminology codes and procedure names for 9 urogynecologic procedures were used to search each chargemaster and extract price listings. Price listings were compared with data on quality, population demographics, and hospital characteristics to determine if any significant relationships existed.

Results
Eight hundred thirty-four chargemasters were identified. Price listings for most procedures differed significantly across the 5 states, including colpocleisis, cystoscopy with chemodenervation, diagnostic cystoscopy, diverticulectomy, sacral neuromodulation, midurethral sling, and sacrospinous ligament fixation. Price listings were significantly higher in urban hospitals than rural hospitals for 6 procedures. No significant association was seen with price listing and quality measures for most procedures.

Conclusions
Listed prices varied for several urogynecologic procedures. Some of this variation is associated with hospital characteristics such as urban setting. However, notably, price listing was not associated with quality. Further investigation of chargemaster price listings with hospital characteristics and quality metrics and with what is actually paid by patients is imperative for patients to navigate charges.
Phenotypic antibiotics susceptibility profile of clinical Enterobacteriaceae isolates from Kaduna State, North-west Nigeria
Authors: Ezeh Peace Amarachukwu , Olayinka Busayo Olalekan , Bolaji Rebecca Olajumoke , Suleiman Babangida Ahmed , Olowookere Ahmed 
Published: December 2023

Background: The increasing resistance of clinical Enterobacteriaceae infection to commonly prescribed antibiotics have been reported around the world. Data is generally lacking on the prevalence and antibiotic susceptibility profile of clinical Enterobacteriaceae isolates from Kaduna, northwest Nigeria. This study thus aimed to determine the diversity of clinical Enterobacteriaceae isolates recovered from clinical specimens of patients admitted into two selected healthcare institutions in Kaduna, Nigeria.
Methods: Non-duplicate clinical bacteria isolates recovered from various specimens were collected and identified using rapid biochemical identification kits. The susceptibility of identified Enterobacteriaceae to various antibiotics and phenotypic detection of carbapenemase enzymes were thereafter determined.
Results: Of the 500 collected bacterial isolates, 108 (21.6 %) were identified as Enterobacteriaceae, with Pantoea agglomerans (52, 48.1%), Klebsiella oxytoca (19, 17.6%) as the most prevalent. The isolates exhibited high resistance to azithromycin (69%) and ceftazidime (42%), while exhibiting low resistance to amikacin (7%) and imipenem (10%). Among the carbapenem-resistant Enterobacteriaceae (CRE) isolates, a significant proportion (66.6 %) tested positive for carbapenemase activity.
Conclusion: This study reports a high prevalence of multi-drug resistant Enterobacteriaceae in Kaduna, northwest Nigeria. The emergence of pathogenic P. agglomerans and an alarmingly high prevalence of carbapenemase-producing CRE are also observed. The presence of carbapenemase producers in an area with low carbapenem usage and resistance rates raises significant concerns. Continuous surveillance and robust antibiotic stewardship policies are imperative to preserve the efficacy of carbapenems in this region.
Arctos: Community-driven innovations for managing biodiversity and cultural collections
Authors: Cicero Carla , Koo Michelle S. , Braker Emily , Abbott John , Bloom David , Campbell Mariel , Cook Joseph A. , Demboski John R. , Doll Andrew C. , Frederick Lindsey M. , Linn Angela J. , Mayfield-Meyer Teresa J. , McDonald Dusty L. , Nachman Michael W. , Olson Link E. , Roberts Dawn , Sikes Derek S. , Witt Christopher C. , Wommack Elizabeth 
Published: December 2023

AbstractMuseum collections house millions of objects and associated data records that document biological and cultural diversity. In recent decades, digitization efforts have greatly increased accessibility to these data, thereby revolutionizing interdisciplinary studies in evolutionary biology, biogeography, epidemiology, cultural change, and human-mediated environmental impacts. Curators and collection managers can make museum data as accessible as possible to scientists and learners by using a collection management system. However, selecting a system can be a challenging task. Here, we describe Arctos, a community solution for managing and accessing collections data for research and education. Specific goals are to: (1) Describe the core elements of Arctos for a broad audience with respect to the biodiversity informatics principles that enable high quality research; (2) Highlight the unique aspects of Arctos; (3) Illustrate Arctos as a model for supporting and enhancing the Digital Extended Specimen; and (4) Emphasize the role of the Arctos community for improving data discovery and enabling cross-disciplinary, integrative studies within a sustainable governance model. In addition to detailing Arctos as both a community of museum professionals and a collection database platform, we discuss how Arctos achieves its richly annotated data by creating a web of knowledge with deep connections between catalog records and derived or associated data. We also highlight the value of Arctos as an educational resource. Finally, we present a financial model of fiscal sponsorship by a non-profit organization, implemented in 2022, to ensure the long-term success and sustainability of Arctos. We attribute Arctos’ longevity of nearly three decades to its core development principles of standardization, flexibility, interdisciplinarity, and connectivity within a nimble development model for addressing novel needs and information types in response to changing technology, workflows, ethical considerations, and regulations.
Circulating Inflammatory Cytokines and Risk of Intracranial Aneurysm: A Mendelian-randomization Study
Authors: Zhang Quan , Liu Tiantian , Zhang Linlin , Yang Rongcheng , Zhao Yao , Sun Xiaojing , Wang Ting , Kuang Xiaoxiao , Liu Hengfang , Liang Jiao , Liu Ya , Feng Tao 
Published: December 2023

AbstractBackgroundMultiple studies have established the significant influence of inflammatory factors on the initiation and advancement of intracranial aneurysm (IA). However, the causality between specific inflammatory cytokines and IA remains uncertain. This study aims to elucidate it using Mendelian randomization (MR).MethodsThe genetic data of cytokines were collected from a genome-wide association study (GWAS) conducted on circulating cytokines in the Finnish population, involving the genetic characteristics of 41 cytokines obtained through a meta-analysis of 8,293 samples. The genetic data for IA were derived from the most extensive GWAS study, which included 7,495 samples from individuals of European ancestry and 71,934 healthy control subjects. The inverse variance weighted method primarily determined the causal correlation between exposures and outcomes. In addition, other robust MR analysis methods and sensitivity analyses were utilized to guarantee the accuracy of the results.ResultsOur results indicate a negative correlation between IP-10 and unruptured intracranial aneurysms (UIA) (odds ratio, OR: 0.63, 95%CI: 0.45-0.9, p=0.01). IL-10 and VEGF exhibit a positive correlation with aneurysmal subarachnoid hemorrhage (aSAH) (OR: 1.19, 95%CI: 1.02-1.39, p=0.024; OR: 1.12, 95%CI: 1.01-1.23, p=0.025). The levels of FGFBasic and TRAIL exhibit a negative correlation with aSAH. (OR: 0.62, 95%CI: 0.42-0.92, p=0.018; OR: 0.89, 95%CI: 0.8-1, p=0.041). The increased levels of IL-12p70, IL-4, IFNg, IL-10, IL-17, IL-1ra, IL-6, IL-9, VEGF, and FGFBasic were observed as the consequence of IA. (Beta: 0.18, 95%CI: 0.08-0.28, p=6.2e-4; Beta: 0.15, 95%CI: 0.07-0.23, p=2e-4; Beta: 0.15, 95%CI: 0.07-0.23, p=3.5e-4; Beta: 0.13, 95%CI: 0.05-0.21, p=1.4e-3; Beta: 0.1, 95%CI: 0.02-0.18, p=0.015; Beta: 0.17, 95%CI: 0.02-0.32, p=0.031; Beta: 0.14, 95%CI: 0.05-0.32, p=0.003; Beta: 0.13, 95%CI: 0.01-0.24, p=0.035; Beta: 0.14, 95%CI: 0.05-0.23, p=0.002; Beta: 0.09, 95%CI: 0.01-0.17, p=0.032).ConclusionOur study suggests that IP-10 may serve as a protective factor for UIA. FGFBasic and TRAIL have demonstrated a defensive impact against aSAH, while IL-10 and VEGF have been identified as factors that elevate the risk of IA rupture. Additionally, the levels of IL-12p70, IL-4, IFNg, and various cytokines are increased due to IA pathogenesis, and these cytokines may have the function of controlling inflammation in the progression of IA.
How clustering promotes biodiversity: A solution to the plankton paradox
Authors: Huruntz Karen K. , Ghukasyan Lilit E. , Gevorgyan Gor A. 
Published: December 2023

AbstractFrom a mathematical perspective, randomly assembled species-rich competitive communities exhibit a high degree of instability, as described by May’s stability theorem. This suggests that actual ecological communities should possess a significant level of organization in their competitive network structure, often with a modular topology, to withstand May’s instability. It is also known that a species-saturated ecological community driven by competitive Lotka–Volterra equations, following a path of competitive exclusion, lingers in a long-term state with species congregated in niche space into well-separated clusters, thereby competing in a modular manner. Without regard to origin, we characterize the modular network topology of interspecific competition in such a community as a hierarchical one, representing interspecific competition and the associated fragmentation of niche space among community species as a two-tiered process. That is, in pairs between species within individual groups (clusters) of ecologically related species, on the one hand, and collectively between these groups as holistic ecological units – ecological species, on the other hand. To illustrate this hierarchical organization, we introduce a generalized multi-resource multi-species competition model that recognizes this topology at the basis of its own network structure of interrelated governing equations of species dynamics. This kind of generalization substantially reduces the competitive exclusion constraints on species coexistence, offering promising potential for a conceptual resolution of the plankton paradox.
Climatic limits to Atlantic salmon population fitness at continental scales
Authors: Morris Olivia , Bárðarson Hlynur , González-Ferreras Alexia , Lauridsen Rasmus , Pawar Samraat , Rosindell James , Woodward Guy 
Published: December 2023

AbstractAnadromous fish populations are declining globally, partly due to acute pressure from rapid environmental change in their freshwater and marine habitats. A more mechanistic understanding of how climatic and land use changes impact their population-level fitness is needed to mitigate these declines. Here we develop a model that successfully captures the thermal niche of the declining Atlantic salmon. This allows us to predict the combined effects of changes in two dominant threats to this species: climate and resource availability. Specifically, the model predicts that a 50% reduction from metabolically optimal resource supply could constrict their thermal niche by ∼7°C. We also show that daily and seasonal temperature fluctuations have a relatively minor impact. A conservative increase of 1.5°C in global temperatures will cause fitness declines for populations in higher climatic regimes, across resource levels. Our results provide new and general insights into factors limiting the distribution of extant Atlantic salmon populations. They also highlight the relative importance of future threats from climatic warming, fluctuations, and changes in resource availability due to land use change.