bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interactions and Biological Pathways Among Metabolomics Products of Patients with Coronary Heart Disease Analyzed Using the Bioinformatics Methods
Authors: Chu Chun , Liu Shengquan , Nie Liangui , Hu Hongming , Liu Yi , Yang Jun 
Published: February 2024

Abstract
Background: Metabolome products are small molecules resulting from cellular metabolism. Studies has used advanced methods of molecular detection to analysis samples of ill patients. Based on bioinformatics analysis, the interactions and biological pathways among metabolome products in patients with coronary heart disease (CHD) were investigated.
Methods: Related studies focusing on the metabolomics analysis of patients with CHD published on CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Nature, Web of Science, Spring, and Science Direct were retrieved. The metabolites in the literature were analyzed statistically and summarized, the differential metabolites were selected and their pathways were analyzed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular annotation of metabolites and related enzymes or transporters were analyzed with the HMDB. Their related properties were visualized using the metPA.
Results: A total of 12 literatures which satisfying the criteria for enrollment were included here. Total 136 metabolites related to CHD were preliminarily screened, and 83 effective metabolites were obtained after the unrecognized metabolites were excluded. 45 pathways were involved. Through the topology analysis (TPA) of pathways, their influence values were calculated, and 14 major metabolic pathways were selected, which were phenylalanine (Phe), tyrosine and tryptophan biosynthesis (TTB), Aminoacyl-tRNA biosynthesis (ATB), and arginine biosynthesis (ABS). These results indicated that glucose metabolism, fatty acid (FA) metabolism, amino acid (AA) transporting to proteins to cells, and tricarboxylic acid (TCA) cycle were involved in the occurrence of CHD.
Conclusion: this study showed cellular and molecular pathways involved in the process of CHD. This information can be used for different drug development and diagnostic studies.
Rare Presentation of Acute Lower Limb Ischemia: Saddle Aortic Embolus with Paraplegia - Case Report
Authors: Almadwahi Nabeel Y. , Alshujaa Mohamed A. , Al-Hashedi Aref A. , Jowah Haitham Mohammed 
Published: February 2024

Abstract
Introduction:
This case report presents a unique and noteworthy occurrence of acute lower limb ischemia (ALI) accompanied by paraplegia in a 60-year-old male patient with a medical history of diabetes mellitus, hypertension, and ischemic heart disease. The novelty of this case lies in the rare association of ALI with paraplegia, which is an unusual and infrequently reported condition.
Case presentation:
A patient who underwent coronary artery bypass graft (CABG) surgery presented 12 days post-surgery with sudden onset right lower limb pain followed by paralysis in both lower limbs. Initially, Guillain-Barré syndrome (GBS) was suspected; however, further evaluation revealed occlusion in the abdominal aorta, common iliac artery, and external iliac arteries. The patient's management involved prompt diagnosis, administration of intravenous heparin, bilateral leg fasciotomy, and thrombectomy. These interventions resulted in the restoration of pulses and improvement in the patient's condition. Nonetheless, postoperative complications in the form of acute kidney injury were observed.
Conclusions
In conclusion, this case highlights the importance of maintaining a broad differential diagnosis when encountering rapidly progressing lower limb paralysis, especially in patients with vascular risk factors. Timely diagnosis and intervention in patients with acute limb ischemia can significantly impact patient outcomes. A multidisciplinary approach involving vascular surgeons, interventional radiologists, critical care specialists, and neurologists is crucial for optimizing patient outcomes in complex scenarios.
Manipulating Spin-Torque Dynamics in Atomic Media Using Kerr Field with Two-Wave Interference
Authors: Tariq Muhammad , Khan Abuzar 
Published: February 2024

Abstract
In this article, Spin density and Torque of two interfering waves are controlled and manipulated by applying two interacting control fields in which one is the Kerr field with Rabi frequency Ω2 and a probe field using a four-level N-type atomic configuration of Rubidium-87 isotope. The spin density of light can be controlled coherently in the atomic medium by electromagnetically induced transparency (EIT). When the strong interacting control fields and the weak probe field are applied to the atomic medium, the Rubidium atoms become transparent to the probe field. It is due to the control fields that ”dress” the atoms, creating a new energy state that the weak probe field can interact with. As a result, the weak probe field can pass through the Rubidium atomic medium without being absorbed. Substantial variations can be seen in the electric SAM and Torque of two interfering waves with variations in the angle β between the two interfering waves, the Rabi frequencies of the control fields, the detuning of the probe field, and the phase difference δϕ between waves. By introducing these changes of parameters in the atomic medium, the spin density of two interfering waves can be made to rotate in a specific direction or at a specific rate. The parameters of control fields and probe field detuning play an essential role in the modification of electric SAM and electric spin vector field distribution of the probe field. The modified work of this manuscript is useful for Quantum computing, Optical communication, Quantum information processing.
Teacher noticing: exploring the nexus between effective implementation and academic performance of basic 12 students in geometry in Builsa South District
Authors: Enoch Enoch Kabinaa 
Published: February 2024

Abstract
Teachers' noticing has become a crucial topic in recent studies because many believe that the teacher’s noticing, interpretation, and attention to students during lesson activities have a great impact on students’ learning and academic performance. This study therefore aimed to explore the nexus between effective noticing implementation and the academic performance of basic 12 students in geometry. The study was purely quantitative descriptive research with a population and sample size of 360 and 186, respectively. A simple random sampling technique was used to select the sample members. Data for the study were collected using a questionnaire survey and a Geometry Achievement Test. Data analysis was done using SPSS’s descriptive procedures and the simple linear regression model. The study found that: 1) there was a significant relationship between effective implementation of noticing in teaching and students’ academic performance in geometry, p(.019). 2). the study recommended that teachers should effectively implement their noticing skills during geometry and mathematics lessons so as to enhance students’ learning and academic performance.
Gravity model applied to intra-community trade in SADC and COMESA
Authors: Sandambi Nerhum , João Mário Augusto Caetano 
Published: February 2024

Abstract
We studied trade flows between the member states of SADC and COMESA, analyzing 27 countries that make up the two regions. In particular, we used a set of data from 1999-2022, specifying 4 different models, and the Hausman-Taylor estimator proved to be relevant in explaining intra-community trade between the two economic integration zones. However, the results suggest that there are positive impacts in the SADC countries. The pull factors translated into physical distance are relevant to intra-community trade between the SADC and COMESA member states. There is strong negative evidence related to the countries' industrial capacity, although there are negative impacts, mainly associated with the countries' low level of industrialization. On the other hand, external influence negatively affects intra-Community trade flows. We also estimated an alternative model, and the results show strong evidence of trade potential in the countries of South Africa, Namibia, Tanzania and Congo Brazzavile. On the other hand, SADC has lower trade potential compared to COMESA, for example, and we measured the intensity of trade between the member states and found higher trade intensity between Angola, Namibia and South Africa and significantly higher trade intensity between South Africa, Botswana, Lesotho, Malawi and Mozambique, i.e. considering bilateral intra-community trade.
JEL classification: F00; C01; C02; C33 & C40.
Unravelling the Metastatic Niche in Breast Cancer Patients with Bone Metastasis through Single-cell RNA Sequencing
Authors: Li Xiangyu , Gao Ziyu , Yang Meiling , Yang Ciqiu , Yang Dongyang , Cui Wenhui , Wu Dandan , Zhou Jie 
Published: February 2024

Abstract
Breast cancer (BRCA) is characterized by a unique metastatic pattern and often presents with bone metastasis (BoM), which poses significant clinical challenges. This study employed single-cell RNA sequencing (scRNA-seq) and TCGA data analysis to compare primary tumor (PT), lymph node metastasis (LN), and BoM data. Our investigation identified a metastatic niche in BoMs marked by an increased abundance of cancer-associated fibroblasts (CAFs) and a reduced immune cell count. A distinct subtype (State 1) of BRCA BoM cells associated with adverse prognosis was identified. State 1, characterized by heightened stemness traits, may represent an initiation phase for BoM in BRCA. Complex cell communications involving tumor, stromal, and immune cells were revealed. Interactions between FN1, SPP1, and MDK correlate with elevated immune cells in the BoM. CD46, MDK, and PTN interactions drive myofibroblast activation and proliferation, contributing to tissue remodelling. Additionally, MDK, PTN, and FN1 interactions influence FAP+ CAF activation, impacting cell adhesion and migration in BoMs. These insights deepen our understanding of the metastatic niche in breast cancer BoMs.
SOCIAL NETWORKS AS A LANGUAGE TEACHING TOOL
Authors: Marinković Milica M. 
Published: February 2024

Social networks constitute an intrinsic part of our lives, not only in private aspects, but also professional and academic ones. Digitalisation in various professional and scientific fields, web 2.0, universal mobility and the growing use of multimedia tools in the classroom have led to the use of social networks as teaching material and tools.
In this work, the main social networks suitable for language teaching will be illustrated and various possibilities for their use will be indicated to derive maximum benefit from them in the classroom or during the student's independent study. Activities that may include the use of digital applications and the ways in which these platforms can be inserted into the different phases of the lesson will be indicated.
Finally, various practical examples of the inclusion of social networks in the classroom will be given, accompanied by intentional reflections to encourage language teachers to include web 2.0 tools among their working methods.
LEXICAL VARIATION AMONG STANDARD LANGUAGE SPEAKERS IN REPUBLIC OF SRPSKA
Authors: Yakushkina E.I. , Crnjak D. 
Published: February 2024

This paper is a part of a larger study of regional variation of the lexicon within the Serbian standard language. About 100 questionnaires were collected for this research from educated speakers of the Serbian language from different cities. The questionnaire contains questions which uncover the use of doublets characteristic of the western and eastern parts of the Serbian linguistic territory, such as željezo and gvožđe, mahune and boranija, kino and bioskop. The paper proposes the analysis of around 60 questionnaires from the Republic of Srpska, namely from Banja Luka (47), Trebinje (7), as well as from Prijedor, Bjelina and East Sarajevo. First, the paper presents a list of investigated regional doublets (200 lexemes), and gives their typological division (phonetic or morphological variants, lexical doublets).
Further, a linguageographic analysis of the first questionnaire is proposed and previously analysed in the other paper, and conclusions about the regional characteristics of the lexicon contained in that questionnaire are presented. For example, it is noted that in Prijedor, unlike Trebinje, words as domaća zadaća, duda, hladetina, hlače, ispričnica, kuhar, kuhati, marelice, neodgojen, propuh, ručnik, tekućina, tržnica, tuka, umjetno gnojivo etc., are used.
The main content of the paper deals with the analysis of the second questionnaire. For each lexical pair presented in the questionnaire, the statistics of the use of each word in Banja-Luka and Trebinje are given, and based on this, the lexicon characteristic of one and the other city is distinguished (e.g. dan i noć, trougao in Trebinje and maćuhice, trokut in Banja Luka), as well as a group of doublet pairs whose members are used equally often in the west and in the east of the Republic of Srpska (oprosti – izvini). Words which practically do not vary are also described. Sometimes the same word is used in Banja Luka and Trebinje, and sometimes it is the same as in Serbia (putarina), or it may be different (narandža instead of pomorandža).
The main conclusion of the research is that the lexicon of the western and eastern type on the territory of the Republic of Srpska is distributed in the form of waves. This means that the use of lexical doublets in Trebinje is more similar to their use in Serbia, while for Banja Luka and Prijedor a higher concentration of western words than in Trebinje is typical.
Further research will be focused on the description of the use of these lexemes in other cities of the Republic of Srpska, as well as their variation on the territory of Serbia.
TRIP13 Activates Glycolysis to Promote Cell Stemness and
Strengthen Doxorubicin Resistance of Colorectal Cancer Cells
Authors: Liu Guangyi , Wang Huan , Ran Rui , Wang Yicheng , Li Yang 
Published: February 2024

Background:
Chemotherapy resistance is one of the main causes of clinical
chemotherapy failure. Current cancer research explores the drug resistance mechanism
and new therapeutic targets. This work aims to elucidate the mechanism of thyroid hormone
receptor interactor 13 (TRIP13) affecting doxorubicin (DOX) resistance in colorectal
cancer (CRC).

Methods:
Bioinformatics analyses were employed to clarify TRIP13 expression in CRC
tissues and predict the correlation of the TRIP13 enrichment pathway with glycolysis-related
genes and stemness index mRNAsi. Quantitative real-time polymerase chain reaction
and western blot were adopted to analyze the expression of TRIP13 and glycolysis-
related genes. Cell Counting Kit-8 was utilized to determine the cell viability and
IC50 value. Western blot was employed to measure the expression of stemness-related
factors. Cell function assays were performed to detect cells' sphere-forming ability and
glycolysis level. Animal models were constructed to determine the effects of TRIP13 expression
on CRC tumor growth.

Results:
TRIP13 was significantly overexpressed in CRC, concentrated in the glycolysis
signaling pathway, and positively correlated with stemness index mRNAsi. High expression
of TRIP13 facilitated DOX resistance in CRC. Further mechanistic studies revealed
that overexpression of TRIP13 could promote cell stemness through glycolysis, which
was also confirmed in animal experiments.

Conclusion:
TRIP13 was highly expressed in CRC, which enhanced the DOX resistance
of CRC cells by activating glycolysis to promote cell stemness. These findings offer
new insights into the pathogenesis of DOX resistance in CRC and suggest that
TRIP13 may be a new target for reversing DOX resistance in CRC.
Immunosuppressive Microenvironment in H3K27 Mutant Pediatric
Diffuse Midline Glioma: Single-Cell and Bioinformatics Insights on
CD8A, IL7R, and ICAM1
Authors: Huang Jianhuang , You Guiting , Chen Quan , Lin Yunpeng , Lin Yijing , Liang Yu , Lin Caihou , Chen Jianwu 
Published: February 2024

Background:
Diffuse midline gliomas (DMG) pose a grave threat as a malignant tumor
primarily affecting children in the pons region. These tumors exhibit a distinct and heightened resistance to therapeutic interventions, coupled with exceptionally aggressive behavior.

Methods:
In this study, we accessed DMG data from the Gene Expression Omnibus (GEO)
database. Subsequently, we performed functional annotation and conducted pathway enrichment
analysis as well as gene set enrichment analysis (GSEA). Constructing a protein-protein interaction (PPI) network, we identified pivotal hub genes. To evaluate the impact of these hub genes on
immune infiltration, we employed the CIBERSORT algorithm. Furthermore, to bolster our findings, we conducted a single-cell analysis.

Results:
Our findings indicate the involvement of CD8A, IL7R, and ICAM1 in immune responses
targeting diverse immune cell types, such as T cells, neutrophils, NK cells, dendritic cells, γδ T
cells, and Macrophages M1. Additionally, the presence of immune checkpoints, including IDO1
and TIGIT, likely contributes to intratumoral immunosuppression, thereby fostering the development of an aggressive phenotype and resistance in pediatric DMG.

Conclusion:
In conclusion, the collective findings of our study suggest the potential role of
CD8A, IL7R, and ICAM1 as innovative biomarkers for diagnosing and prognosticating pediatric
DMG. Moreover, these molecules hold promise as therapeutic targets in the management of this
disease. The implications of our research underscore the importance of exploring these novel avenues for improved patient outcomes.
Uncovering the Mechanisms of Cinnamic Acid Treating Diabetic Nephropathy Based on Network Pharmacology, Molecular Docking, and
Experimental Validation
Authors: Dai Limiao , He Yang , Zheng Siqiang , Tang Jiyu , Fu Lanjun , Zhao Li 
Published: February 2024

Background:
Cinnamic acid (Cinn) is a phenolic acid of Cinnamomum cassia (L.) J.
Presl. that can ameliorate diabetic nephropathy (DN). However, comprehensive therapeutic targets
and underlying mechanisms for Cinn against DN are limited.

Objective:
In this study, a network pharmacology approach and in vivo experiments were
adopted to predict the pharmacological effects and mechanisms of Cinn in DN therapy.

Methods::
The nephroprotective effect of Cinn on DN was investigated by a streptozotocininduced
diabetes mellitus (DM) mouse model. The protein-protein interaction network of Cinn
against DN was established by a network pharmacology approach. The core targets were then
identified and subjected to molecular docking with Cinn.

Results:
Cinn treatment effectively restored body weight, ameliorated hyperglycemia, and reduced
kidney dysfunction markers in DM mice, also demonstrating a reduction in tissue injury.
Network pharmacology analysis identified 298 DN-Cinn co-target genes involved in various
biological processes and pathways. Seventeen core targets were identified, eight of which
showed significant differential expression in the DN and healthy control groups. Molecular
docking analysis revealed a strong interaction between Cinn and PTEN. Cinn treatment downregulated
the PTEN protein expression in DM mice.

Conclusion:
This study revealed the multi-target and multi-pathway characteristics of Cinn
against DN. Cinn improved renal pathological damage of DN, which was related to the downregulation
of PTEN.

other:
not applicable.
Therapeutic Potential of MSC-conditioned Medium: A Multifactorial
Approach to Enhance Wound Healing
Authors: Anbiyaiee Amir , Azizidoost Shirin , Farzaneh Maryam 
Published: February 2024

Abstract:
Wound healing is a highly intricate process that involves a coordinated interplay of
various cellular and molecular events. In recent years, mesenchymal stem cells (MSCs) have
garnered significant attention as a promising therapeutic modality due to their remarkable regenerative properties. In addition to their capacity for direct tissue repair and differentiation,
MSCs release a diverse repertoire of bioactive factors into the surrounding microenvironment,
collectively termed an MSC-conditioned Medium (MSC-CM). This review aims to elucidate the
therapeutic potential of MSC-CM as a multifactorial approach to enhance wound healing. MSCCM encompasses an extensive range of factors, including growth factors, cytokines, chemokines, extracellular matrix proteins, and non-coding RNAs, which collectively orchestrate and
stimulate multiple cellular processes crucial for effective wound healing. Notably, these factors
play pivotal roles in promoting angiogenesis, stimulating the proliferation and migration of various cell types involved in wound repair, modulating the immune response, and facilitating extracellular matrix remodeling. Moreover, compelling evidence from preclinical and clinical
studies demonstrates that MSC-CM administration accelerates wound closure, enhances reepithelialization, and improves the quality of granulation tissue. By harnessing the therapeutic
potential of MSC-CM, we can pave the way for significant advancements in wound care, ultimately leading to improved patient outcomes.
An Insight into the Traditional Uses, Phytochemicals, and Pharmacological
Properties of Polyalthia bullata King
Authors: Hamid Hazrulrizawati Abd , Giwa Hadiza Shehu 
Published: February 2024

Abstract:
Polyalthia bullata King or Tongkat Ali Hitam, a term in the Malay language, encompasses a diverse group of plants belonging to different genera of the Annonaceae family. The
native range of this species is Myanmar to Peninsula Malaysia, Borneo. It is a shrub or tree and
grows primarily in the wet tropical biome. These plants have been utilized in Malaysia and
Southeast Asia as an herbal aphrodisiac. The extracts of this plant have been reported to exert
pharmacological activities, such as antioxidant, cytotoxicity, and aphrodisiac properties. The
therapeutic properties of P. bullata are attributed to the presence of alkaloids and flavonoids.
This study thoroughly analyzes the phytochemical and pharmacological research on P. bullata
and its traditional medicinal properties. The review aims to provide a critical update on the scientific knowledge of P. bullata and to identify novel possibilities for investigating its therapeutic
potential. There is limited scientific research on the phytochemical components and pharmaceutical application of P. bullata. To date, only a few compounds have been identified and isolated.
There is a need for future studies to focus on the extraction technology, phytochemical profiling,
and isolation of bioactive compounds from P. bullata to fill the research gap as well as to provide an important theoretical basis and valuable references for researchers and pave the way for
the discovery and development of new and existing drugs.