bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions
Authors: Szabo Georgina , Szigeti F. Judit , Sipos Miklos , Varbiro Szabolcs , Gonda Xenia 
Published: December 2023

AbstractInfertility has a multifactorial background, where, besides somatic factors, psychological contributors also play a role in development and outcome. While affective temperaments have been associated with development, course, and outcome as well as treatment success in various somatic conditions, their association with infertility and its treatment has not been investigated so far. The purpose of our retrospective cohort study was to evaluate the influence of affective temperaments on fertility treatment outcomes. Among 578 women who underwent infertility treatment in an Assisted Reproduction Centre in Budapest, Hungary, treatment success, detailed medical history, and demographic parameters were recorded, and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) was administered. Possible predictors of assisted reproduction outcome were analyzed using multivariate logistic regression models, followed by a receiver operating curve (ROC) analysis in order to define ideal affective temperament cut-off values for clinical applicability. Aside from age, BMI, and previous miscarriage, cyclothymic scores > 4 (OR = 0.51 CI 0.35–0.74, p < 0.001), depressive scores > 9 (OR = 0.59 CI 0.4–0.87, p = 0.009) and anxious scores > 9 (OR = 0.45 CI 0.31–0.66, p < 0.001) significantly decreased the odds of clinical pregnancy by 49%, 41% and 55%, respectively. Irritable and hyperthymic temperaments, as well as other somatic and socio-economic factors had no effect on infertility treatment outcomes. The results suggest that affective temperaments may be related to the outcome of infertility treatments. Thus, screening for affective temperaments may help identify high-risk patient groups and offer patient-tailored treatment, which may increase the chances of a successful pregnancy and live birth for women undergoing IVF treatment.
Numerical investigation of a typhoid disease model in fuzzy environment
Authors: Dayan Fazal , Ahmed Nauman , Ali Ali Hasan , Rafiq Muhammad , Raza Ali 
Published: December 2023

AbstractSalmonella Typhi, a bacteria, is responsible for typhoid fever, a potentially dangerous infection. Typhoid fever affects a large number of people each year, estimated to be between 11 and 20 million, resulting in a high mortality rate of 128,000 to 161,000 deaths. This research investigates a robust numerical analytic strategy for typhoid fever that takes infection protection into consideration and incorporates fuzzy parameters. The use of fuzzy parameters acknowledges the variation in parameter values among individuals in the population, which leads to uncertainties. Because of their diverse histories, different age groups within this community may exhibit distinct customs, habits, and levels of resistance. Fuzzy theory appears as the most appropriate instrument for dealing with these uncertainty. With this in mind, a model of typhoid fever featuring fuzzy parameters is thoroughly examined. Two numerical techniques are developed within a fuzzy framework to address this model. We employ the non-standard finite difference (NSFD) scheme, which ensures the preservation of essential properties like dynamic consistency and positivity. Additionally, we conduct numerical simulations to illustrate the practical applicability of the developed technique. In contrast to many classical methods commonly found in the literature, the proposed approach exhibits unconditional convergence, solidifying its status as a dependable tool for investigating the dynamics of typhoid disease.
An α-chain modification rivals the effect of fetal hemoglobin in retarding the rate of sickle cell fiber formation
Authors: Worth Eli H. , Fugate Mark K. , Grasty Kimberly C. , Loll Patrick J. , Bishop Marilyn F. , Ferrone Frank A. 
Published: December 2023

AbstractAdults with sickle cell disease bear a mutation in the β-globin gene, leading to the expression of sickle hemoglobin (HbS; α2βS2). Adults also possess the gene for γ-globin, which is a component of fetal hemoglobin (HbF, α2γ2); however, γ-chain expression normally ceases after birth. As HbF does not form the fibers that cause the disease, pharmacological and gene-modifying interventions have attempted to either reactivate expression of the γ chain or introduce a gene encoding a modified β chain having γ-like character. Here, we show that a single-site modification on the α chain, αPro114Arg, retards fiber formation as effectively as HbF. Because this addition to the repertoire of anti-sickling approaches acts independently of other modifications, it could be coupled with other therapies to significantly enhance their effectiveness.
Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection
Authors: Bonde Charlotte Smith , Mejer Helena , Myhill Laura J. , Zhu Ling , Jensen Penille , Büdeyri Gökgöz Nilay , Krych Lukasz , Nielsen Dennis Sandris , Skovgaard Kerstin , Thamsborg Stig Milan , Williams Andrew R. 
Published: December 2023

AbstractBrown seaweeds have a rich bioactive content known to modulate biological processes, including the mucosal immune response and microbiota function, and may therefore have the potential to control enteric pathogens. Here, we tested if dietary seaweed (Saccharina latissima) supplementation could modulate pig gut health with a specific focus on parasitic helminth burdens, gut microbiota composition, and host immune response during a five week feeding period in pigs co-infected with the helminths Ascaris suum and Oesophagostomum dentatum. We found that inclusion of fermented S. latissima (Fer-SL) at 8% of the diet increased gut microbiota α-diversity with higher relative abundances of Firmicutes, Tenericutes, Verrucomicrobia, Spirochaetes and Elusimicrobia, and lower abundance of Prevotella copri. In the absence of helminth infection, transcription of immune-related genes in the intestine was only moderately influenced by dietary seaweed. However, Fer-SL modulated the transcriptional response to infection in a site-specific manner in the gut, with an attenuation of infection-induced gene expression in the jejunum and an amplification of gene expression in the colon. Effects on systemic immune parameters (e.g. blood lymphocyte populations) were limited, indicating the effects of Fer-SL were mainly localized to the intestinal tissues. Despite previously documented in vitro anti-parasitic activity against pig helminths, Fer-SL inclusion did not significantly affect parasite egg excretion or worm establishment. Collectively, our results show that although Fer-SL inclusion did not reduce parasite burdens, it may modify the gut environment during enteric parasite infection, which encourages continued investigations into the use of seaweeds or related products as novel tools to improve gut health.
Understanding the association between county-level unemployment and health stratified by education and income in the southwestern United States
Authors: Majeed Hamnah , Baumann Shyon , Majeed Haris 
Published: December 2023

AbstractPast research on the relationship between unemployment rates and population health has produced mixed findings. The relationship can be influenced by the kinds of health outcomes observed, time frame, level of geographic aggregation, and other factors. Given these mixed findings, there is a need to add to our knowledge about how unemployment rates and population health are related. There is limited research that examines the association of unemployment rates with both physical and mental health, while simultaneously stratifying populations by income and education levels. Using survey-based self-reported data, this first population-based study examined the association between unemployment rates and physically and mentally unhealthy days in the southwestern United States, by county-level stratification of income (high and low) as well as education (high and low), from 2015 to 2019. After controlling for covariates, associations were modelled using negative binomial regression, with autocorrelative residuals, and were reported as rate ratios (RR). Overall, we found that a 1% rise in unemployment rates was significantly associated with an increase in physically unhealthy days [adjusted RR 1.007; 95% CI, 1.004–1.011, P < 0.001] and mentally unhealthy days [RR 1.006; 95% CI, 1.003–1.009, P  < 0.001]. Upon stratification, a significant risk was found among the high education and high income category [RR 1.035; 95% CI, 1.021–1.049, P  < 0.001], as well as for the high education and low income category [RR 1.026; 95% CI, 1.013–1.040, P  < 0.001]. A better understanding of how unemployment is associated with the health of communities with different education and income levels could help reduce the burden on society through tailored interventions and social policies not only in the United States, but also in other developed nations.
Temporal stability and correlation of EEG markers and depression questionnaires scores in healthy people
Authors: Põld Toomas , Päeske Laura , Hinrikus Hiie , Lass Jaanus , Bachmann Maie 
Published: December 2023

AbstractMental disorders, especially depression, have become a rising problem in modern society. The development of methods and markers for the early detection of mental disorders is an actual problem. Psychological questionnaires are the only tools for evaluating the symptoms of mental disorders in clinical practice today. The electroencephalography (EEG) based non-invasive and cost-effective method seems feasible for the early detection of depression in occupational and family medicine centers and personal monitoring. The reliability of the EEG markers in the early detection of depression assumes their high temporal stability and correlation with the scores of depression questionnaires. The study was been performed on 17 healthy people over three years. Two hypotheses have been evaluated in the current study: first, the temporal stability of EEG markers is close to the stability of the scores of depression questionnaires, and second, EEG markers and depression questionnaires’ scores are not correlated in healthy people. The results of the performed study support both hypotheses: the temporal stability of EEG markers is high and close to the stability of depression questionnaires scores and the correlation between the EEG markers and depression questionnaires scores is not detected in healthy people. The results of the current study contribute to the interpretation of results in depression EEG studies and to the feasibility of EEG markers in the detection of depression.
Development and evaluation of a colorimetric LAMP-based biosensor for rapid detection of a nosocomial infection agent, Citrobacter freundii
Authors: Mollasalehi Hamidreza , Esmaili Faezeh , Minai-Tehrani Dariush 
Published: December 2023

AbstractSimple and fast diagnosis of Citrobacter freundii which is an important cause of nosocomial infection in human is crucial to achieve early treatment. We have developed and evaluated an optical LAMP-based biosensor for the visual detection of C. freundii for the first time. The efficiency of the assay was investigated and compared to PCR method. The selectivity and specificity of the biosensor were analyzed using Morganella morganii, Enterobacter aerogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, Shigella sonnei, Serratia marcescens, Burkholderia cepacia and Klebsiella pneumoniae and a mixed-culture medium. Endpoint analysis using hydroxy naphthol blue was applied, and the color change to sky blue and no color change from violet indicated positive and negative results, respectively. The absorption at 650 nm was measured 0.39 for the positive sample, while the mean absorption of the test samples, including water, was 0.23. The specificity of the method was equal to that of PCR. However, the sensitivity was determined as 12.24 fg/µL of the genomic content of C. freundii, higher than PCR assay. The developed LAMP-based method provided a rapid and accurate technique for molecular diagnostics of C. freundii, making it a suitable technique for point-of-care diagnostics in cases of urgent situations.
Label-free electrochemical cancer cell detection leveraging hemoglobin-encapsulated silver nanoclusters and Cu-MOF nanohybrids on a graphene-assisted dual-modal probe
Authors: Zare Ali-Akbar , Naderi-Manesh Hossein , Naghib Seyed Morteza , Shamsipur Mojtaba , Molaabasi Fatemeh 
Published: December 2023

AbstractBreast cancer detection at an early stage significantly increases the chances of successful treatment and survival. This study presents an electrochemical biosensor for detecting breast cancer cells, utilizing silver nanoclusters encapsulated by hemoglobin and Cu (II)-porphyrin-metal organic framework (BioMOF) in a graphene-incorporated nanohybrid probe. This Hb-AgNCs@MOF-G probe demonstrates high electrochemical activity, superior dispersity, porosity, and a large surface area for effective functionalization. Using a green ultrasonic-assisted stirring method, we fabricate ultra-small 5 nm particles that readily immobilize on a glassy carbon electrode, generating a detection signal when interacting with ferricyanide/ferrocyanide redox probes. The resulting immunosensor detects as few as 2 cells/mL using Electrochemical Impedance Spectroscopy (EIS) “signal on” and 16 cells/mL via Square Wave Voltammetry (SWV) “signal off”, within a broad range of cell concentrations (102–5 × 104 cells/mL). Our designed sensor shows improved selectivity (5- to 16-fold) and robust detection in human blood with a recovery efficiency between 94.8–106% (EIS method) and 95.4–111% (SWV method). This sensor could streamline early cancer diagnosis and monitor patient treatment without requiring labelling or signal amplification. As a pioneering endeavor, we've utilized integrated porous MOFs with Hb-encapsulated silver nanoclusters in cancer detection, where these components collectively enhance the overall functionality.
Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome
Authors: Porta-Sánchez Andreu , Mazzanti Andrea , Tarifa Carmen , Kukavica Deni , Trancuccio Alessandro , Mohsin Muhammad , Zanfrini Elisa , Perota Andrea , Duchi Roberto , Hernandez-Lopez Kevin , Jáuregui-Abularach Miguel Eduardo , Pergola Valerio , Fernandez Eugenio , Bongianino Rossana , Tavazzani Elisa , Gambelli Patrick , Memmi Mirella , Scacchi Simone , Pavarino Luca F. , Franzone Piero Colli , Lentini Giovanni , Filgueiras-Rama David , Galli Cesare , Santiago Demetrio Julián , Priori Silvia G. 
Published: December 2023

AbstractTimothy syndrome 1 (TS1) is a multi-organ form of long QT syndrome associated with life-threatening cardiac arrhythmias, the organ-level dynamics of which remain unclear. In this study, we developed and characterized a novel porcine model of TS1 carrying the causative p.Gly406Arg mutation in CACNA1C, known to impair CaV1.2 channel inactivation. Our model fully recapitulated the human disease with prolonged QT interval and arrhythmic mortality. Electroanatomical mapping revealed the presence of a functional substrate vulnerable to reentry, stemming from an unforeseen constitutional slowing of cardiac activation. This signature substrate of TS1 was reliably identified using the reentry vulnerability index, which, we further demonstrate, can be used as a benchmark for assessing treatment efficacy, as shown by testing of multiple clinical and preclinical anti-arrhythmic compounds. Notably, in vitro experiments showed that TS1 cardiomyocytes display Ca2+ overload and decreased peak INa current, providing a rationale for the arrhythmogenic slowing of impulse propagation in vivo.
Enhancing PV distributed generator planning in medium‐voltage DC distribution networks: A multi‐design techno‐economic analysis with load demand response
Authors: Zellagui Mohamed , Belbachir Nasreddine , Lasmari Adel , Molu Reagan Jean Jacques , Kamel Salah 
Published: December 2023

AbstractDistributed generators have grown in significance for the technical and financial operation of electric power systems in recent years. The integration of these generators into the electrical distribution network (EDN) has experienced rapid growth, primarily driven by advancements in renewable energy sources (RESs), particularly photovoltaic distributed generators (PVDGs). With the increasing implementation of solar energy as a RES, designing the optimal integration of PVDGs into medium voltage direct current (MVDC) networks is crucial to comprehensively analyzing technical and economic factors. To address this issue, a new multiple objective function (MOF) is proposed, which combines various techno‐economic parameters such as total active power loss (APL), voltage deviation (VD), and the investment cost of PVDGs (ICPVDG) installed in the test system. The objective is to minimize the MOF simultaneously to achieve the optimal incorporation of PVDGs. This study aims to solve the allocation problems related to the location and size of PVDG units in the modified MVDC test systems IEEE 27 and 33‐bus. Simulation results demonstrate the superior accuracy and effectiveness of the equilibrium optimization algorithm (EOA) in achieving the minimum MOF. The utilization of multiple PVDG units reduces overall active power losses and improves voltage profiles across all buses.
Improving the performance of high‐sensitivity surface plasmon resonance biosensor with 2D nanomaterial coating (BP‐WS2) based on hybrid structure: Theoretical analysis
Authors: Didar Rita Fatanat , Vahed Hamid 
Published: December 2023

AbstractThe authors theoretically designed a highly sensitive SPR biosensor with a hybrid structure using two‐dimensional nanomaterials (BP‐WS2). Using the transfer matrix method (TMM), the performance of the sensor in terms of reflection, sensitivity, detection accuracy, and quality factor is investigated, and by changing the structural parameters of the sensor, the obtained results are further analysed so that an optimal structure with optimal performance can be achieved. The sensor was optimised with four layers of BP and a single layer of WS2. This composite structure is placed on a 50 nm thick gold layer and concluded with a maximum sensitivity of 234 deg/RIU with a FOM of 26.53 RIU−1. This biosensor is designed by considering the advantages and characteristics of biosensors in their resistance and high electrical properties, as well as the ability to detect diseases quickly.
Bearing‐only motion analysis of target based on low‐quality bearing‐time recordings map
Authors: Zhang Yanhou , Wang Chao , Zhang Qi , Da Lianglong , Jiang Zhaozhen 
Published: December 2023

AbstractAccurate bearing‐time recordings play a crucial role in hydroacoustic target motion analysis and situation estimation. The target bearing estimated by vector hydrophone in the interference environment suffers from poor display and low signal‐to‐noise ratio. To solve this problem, a two‐stage bearing‐only motion analysis method is proposed. Firstly, the bearing peak information and bearing dispersion are extracted for each sampling moment of the bearing‐time recording. Custom constraint regions and adaptive parameters are then set based on this information. The order truncate average algorithm is improved to enhance the quality of the low‐quality bearing‐time recording map. Secondly, a bearing‐only target motion model is established based on the bearing‐time recording distribution features, and a bearing‐time recording trust interval is constructed. Then a modified pseudo‐linear estimation algorithm is proposed to solve the target motion situation information, including target abeam time, target abeam bearing, target course, velocity‐to‐initial‐distance ratio, and so forth. Finally, by comparing the solved values of the sea trial data with the automatic identification system calculation results, the enhancement effect of the target bearing‐time recording map is significant and the solving error of the target motion elements meets the needs of engineering applications.
Welding Fume Mitigation
Authors: Shinde Vishal , Rodge Someshwar , Vethekar Abhijit 
Published: December 2023

In order to maintain a healthy and safe work environment the global occupational exposure limits for manganese were reviewed and initiative to reduce welding fume concentrations initiated [1].
There are different techniques available to capture welding fumes, At source weld fume capture is one of the technics used in One of the John Deere Factory, Welding torch equipped with the fume absorption system to capture the fumes generated during welding. For implementation detail study of the existing robot cell infrastructure was done [2]. It results in 80% of fume filtration and 2.79 MT (Table.2) of welding harmful gases filtered and recirculated in the atmosphere [3].
The friction-induced microstructures changes of 18Cr-8Ni austenitic stainless steels with different grain sizes
Authors: Liu J , Wang H J , Huang L , Ma X , Deng X T , Wang Z D 
Published: December 2023

Abstract
The friction and wear performance, wear morphology and friction-induced subsurface microstructural characteristics of 18Cr-8Ni austenitic stainless steels with coarse-grained (CG), heterogeneous ultrafine-grained (HUFG), and nano/ultrafine-grained (NG/UFG) microstructures after dry sliding wear under room temperature were studied. The results reveal that HUFG steel with a good match between hardness and plasticity exhibits the best wear performance, followed by CG steel, while NG/UFG steel with the highest hardness exhibits the poorest wear performance. From the element distribution map, the contents of O and Si in the delamination and wear debris are relatively high. O is relatively evenly distributed on the whole wear surface of HUFG steel, and there is a continuous oxide layer on its wear surface. After the wear test, the hardness increment near the wear surface of the CG sample is the largest, and the depth affected by sliding is the largest, followed by the HUFG sample, and those of the NG/UFG steel are the smallest. The repeated frictional shear stress causes the formation of cracks between the mechanical mixed layer and the plastic deformation layer, and the continuous expansion of cracks can help oxygen elements diffuse deeply, causing the deformation layer materials to fall off.
Neurocysticercosis: Isolated Lesion in the Left Middle Frontal Gyrus
Authors: Mathew Abel S , Clark Carly , Lauro Peter M , Khalid Zain , McLaughlin Nicole C R 
Published: December 2023

Abstract

Objective
Neurocysticercosis (NCC) is one of the most common parasitic infections of the central nervous system. We present a case study of a 21-year-old African man with an isolated NCC lesion to the left middle frontal gyrus, which is also known as the dorsolateral prefrontal cortex (dlPFC).

Method
A neuropsychological evaluation was requested by the patient’s inpatient psychiatry team regarding worsening attention and depressive symptoms approximately 6 months after NCC diagnosis and treatment.

Results
Neuropsychological findings revealed deficits in the aspects of executive functioning, attention, working memory, and significant depressive symptoms.

Conclusion
To our knowledge, this is the first case study of its kind demonstrating deficits in cognitive functioning consistent with the dlPFC lesion location. Sociocultural and linguistic considerations, clinical findings, and limitations are discussed.