bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence of postpartum manic or mixed episodes in women with bipolar I disorder: A systematic review and meta‐analysis
Authors: Sharma Verinder , Wood Katelyn N. , Weaver Bruce , Mazmanian Dwight , Thomson Michael 
Published: January 2024

AbstractObjectiveAccurate information on the frequency and prevalence of manic or mixed episodes is important for therapeutic, prognostic, and safety concerns. We aimed to estimate the risk of relapse of manic and mixed episodes after delivery in women with bipolar I disorder or schizoaffective disorder—bipolar type.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, a comprehensive literature search in PubMed, PsycINFO, Embase, and Cochrane databases was carried out on November 17, 2022, using the terms ((bipolar disorder) OR (manic depressive illness)) AND (mania)) AND (postpartum)) AND (recurrence)) AND (relapse). The search was updated on March 29, 2023. Case studies and qualitative analyses were excluded. Twelve studies reporting on 3595 deliveries in 2183 women were included in the quantitative analysis.ResultsThe overall pooled estimate of postpartum relapse risk was 39% (95% CI = 29, 49; Q(11) = 211.08, p < 0.001; I2 = 96.31%). Among those who had a relapse, the pooled estimate of risk for manic and mixed episodes was 38% (95% CI = 28, 50; Q(11) = 101.17, p < 0.001; I2 = 91.06%). Using data from the nine studies that reported the percentage of medication use during pregnancy, we estimated a meta‐regression model with the percent medication use as a continuous explanatory variable. The estimated prevalence of relapse was 58.1% (95% CI, 9.6 to 39.3 to 76.8) for studies with no medication use and 25.9% (95% CI, 10.5–41.3) for studies with 100% medication use. The difference between the two prevalence estimates was statistically significant, z = −2.099, p = 0.0359.ConclusionsOur findings suggest an overall pooled estimate of postpartum relapse risk of 39%, while the pooled estimate of risk for manic and mixed episodes was 38%. These findings highlight the need to educate patients with bipolar I disorder, and their healthcare professionals about the high risk of relapse of manic or mixed episodes after delivery.
The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis
Authors: Steinmaurer Anja , Riedl Christian , König Theresa , Testa Giulia , Köck Ulrike , Bauer Jan , Lassmann Hans , Höftberger Romana , Berger Thomas , Wimmer Isabella , Hametner Simon 
Published: January 2024

AbstractActivation of Bruton's tyrosine kinase (BTK) has been shown to play a crucial role in the proinflammatory response of B cells and myeloid cells upon engagement with B cell, Fc, Toll‐like receptor, and distinct chemokine receptors. Previous reports suggest BTK actively contributes to the pathogenesis of multiple sclerosis (MS). The BTK inhibitor Evobrutinib has been shown to reduce the numbers of gadolinium‐enhancing lesions and relapses in relapsing–remitting MS patients. In vitro, BTK inhibition resulted in reduced phagocytic activity and modulated BTK‐dependent inflammatory signaling of microglia and macrophages. Here, we investigated the protein expression of BTK and CD68 as well as iron accumulation in postmortem control (n = 10) and MS (n = 23) brain tissue, focusing on microglia and macrophages. MS cases encompassed active, chronic active, and inactive lesions. BTK+ and iron+ cells positively correlated across all regions of interests and, along with CD68, revealed highest numbers in the center of active and at the rim of chronic active lesions. We then studied the effect of BTK inhibition in the human immortalized microglia‐like HMC3 cell line in vitro. In particular, we loaded HMC3 cells with iron‐dextran and subsequently administered the BTK inhibitor Evobrutinib. Iron treatment alone induced a proinflammatory phenotype and increased the expression of iron importers as well as the intracellular iron storage protein ferritin light chain (FTL). BTK inhibition of iron‐laden cells dampened the expression of microglia‐related inflammatory genes as well as iron‐importers, whereas the iron‐exporter ferroportin was upregulated. Our data suggest that BTK inhibition not only dampens the proinflammatory response but also reduces iron import and storage in activated microglia and macrophages with possible implications on microglial iron accumulation in chronic active lesions in MS.
Interleukin‐4 induced 1‐mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma
Authors: Hirose Shiho , Mashima Tetsuo , Yuan Xunmei , Yamashita Makiko , Kitano Shigehisa , Torii Shinichi , Migita Toshiro , Seimiya Hiroyuki 
Published: January 2024

AbstractCancer cells adopt multiple strategies to escape tumor surveillance by the host immune system and aberrant amino acid metabolism in the tumor microenvironment suppresses the immune system. Among the amino acid‐metabolizing enzymes is an L‐amino‐acid oxidase called interleukin‐4 induced 1 (IL4I1), which depletes essential amino acids in immune cells and is associated with a poor prognosis in various cancer types. Although IL4I1 is involved in immune metabolism abnormalities, its effect on the therapeutic efficacy of immune checkpoint inhibitors is unknown. In this study, we established murine melanoma cells overexpressing IL4I1 and investigated their effects on the intratumor immune microenvironment and the antitumor efficacy of anti‐programmed death‐ligand 1 (PD‐L1) antibodies (Abs) in a syngeneic mouse model. As a result, we found that IL4I1‐overexpressing B16‐F10‐derived tumors showed resistance to anti‐PD‐L1 Ab therapy. Transcriptome analysis revealed that immunosuppressive genes were globally upregulated in the IL4I1‐overexpressing tumors. Consistently, we showed that IL4I1‐overexpressing tumors exhibited an altered subset of lymphoid cells and particularly significant suppression of cytotoxic T cell infiltration compared to mock‐infected B16‐F10‐derived tumors. After treatment with anti‐PD‐L1 Abs, we also found a more prominent elevation of tumor‐associated macrophage (TAM) marker, CD68, in the IL4I1‐overexpressing tumors than in the mock tumors. Consistently, we confirmed an enhanced TAM infiltration in the IL4I1‐overexpressing tumors and a functional involvement of TAMs in the tumor growth. These observations indicate that IL4I1 reprograms the tumor microenvironment into an immunosuppressive state and thereby confers resistance to anti‐PD‐L1 Abs.
‘This is what happens to people who don't spank their kids’: An analysis of YouTube comments to news reports of child to parent violence
Authors: Cortina Helena , Holt Amanda 
Published: January 2024

AbstractChild to parent violence (CPV) is a form of family violence that has seen a growth in research attention over the past decade. However, little research has examined how this problem is understood by those outside of academia. This is despite recognition that public understandings of a particular social problem shape the landscape in which that problem plays out. To address this research gap, we analysed data from 463 public comments posted on YouTube in response to four UK news broadcasts that reported on the problem. Using a discourse analytic approach, we examined how posted comments framed the cause of, and solutions to, CPV. While a range of causes were identified, the posts predominantly blamed the parents, mobilizing child development discourses to attribute the cause of CPV to either parental use of violence, or to a lack of parental violence, towards children. The solutions offered reflect a penal populism that supports extremely punitive sanctions against children who engage in CPV. This study suggests that public campaign and education initiatives need to do more than raise public awareness about CPV—they must also inform the public about how broader social policy operates in relation to children, families and the state.
Harm perceptions of vaping nicotine relative to cigarette smoking among sexual and gender minority young adults
Authors: Lipperman‐Kreda Sharon , Sanders Emile , Annechino Rachelle , Peterkin Elaina , Antin Tamar M. J. 
Published: January 2024

AbstractIntroductionTo address gaps in existing research, the current study used a mixed‐methods approach to describe, contextualise and understand harm perceptions of vaping nicotine relative to cigarette smoking and associations with nicotine and tobacco (NT) use among young adults who identify their genders and sexualities in ways that classify them as sexual and gender minorities (SGM).MethodsResults are based on cross‐sectional surveys and online qualitative interviews with 98 SGM young adults (18–25 years old) in California's San Francisco Bay Area who currently or formerly used combustible tobacco. We generated a measure assessing participants' relative harm perceptions of e‐cigarette use versus cigarette smoking and identified those who perceived cigarette smoking as more harmful than e‐cigarette use compared to those who perceived it to be equally or less harmful.ResultsWe found that relative harm perceptions of cigarette smoking versus e‐cigarette use are likely related to much uncertainty and confusion about the harms of e‐cigarette use. Moreover, findings illustrate that public health messages regarding the risks of e‐cigarette use may have unintended consequences of increasing cigarette use to replace e‐cigarette use for some SGM young adults, a practice that is incongruent with scientific evidence demonstrating that cigarettes and other combustible tobacco products are riskier than e‐cigarettes and other forms of NT use.Discussion and ConclusionsResults suggest the need for evidence‐based, clear, and direct messaging about the relative harms of cigarettes versus e‐cigarettes to reduce NT‐related inequities in SGM populations.
Non‐biologic immunosuppressive drugs for inflammatory and autoimmune skin diseases
Authors: Kanatoula Danai Dionysia , Bodner Euna , Ghoreschi Kamran , Meier Katharina , Solimani Farzan 
Published: January 2024

SummaryNon‐biologic immunosuppressive drugs, such as azathioprine, dapsone or methotrexate are fundamental treatment options for a wide range of autoimmune and chronic inflammatory skin diseases. Some of these drugs were initially used for malignancies (e.g., azathioprine or methotrexate) or infectious diseases (e.g., hydroxychloroquine or dapsone) but are nowadays mostly used for their immunosuppressive/immunomodulating action. Although dermatologists have years of clinical experience with these drugs, some of the mechanisms of action are not fully understood and are the subject of research. Although these drugs are commonly used, lack of experience or knowledge regarding their safety profiles and management leads to skepticism among physicians. Here, we summarize the mechanism of action and detailed management of adverse effects of the most commonly used immunosuppressive drugs for skin diseases. Furthermore, we discuss the management of these drugs during pregnancy and breastfeeding, as well as their interaction and handling during vaccination.
O‐Health‐Edu: A viewpoint into the current state of oral health professional education in Europe: Part 2: Curriculum structure, facilities, staffing and quality assurance
Authors: Dixon Jonathan , Tubert‐Jeannin Stephanie , Davies Julia , van Harten Maria , Roger‐Leroi Valerie , Vital Sibylle , Paganelli Corrado , Akota Ilze , Manzanares‐Cespedes Maria Cristina , Murphy Denis , Gerber Gabor , Quinn Barry , Field James 
Published: January 2024

AbstractIntroductionOral health professional (OHP) education is likely to vary across Europe in accordance with an EU directive that is open to broad interpretation. It is not clear how OHP curricula are structured or delivered across Europe. The objectives of Part 2 of this paper series are: (i) to provide an overview of common practices in curriculum structure, the availability of facilities, staffing (faculty) and quality assurance processes and (ii) to consider how the existing programme structures align to stakeholder guidance documents.MethodsA total of 27 questions from a 91‐item questionnaire were used for this manuscript. The questionnaire was developed following the Delphi method to establish consensus from a group of experts. Members of the research team and colleagues from other countries in Europe completed a multi‐step piloting process. An online data hub was created to allow the respondents to be data controllers and respond to the questionnaire. ADEE member schools (n = 144) were invited to provide data.ResultsTotally, 71 institutions from 25 European countries provided data between June 2021 and April 2023, which represents a response rate of 49.3% of ADEE members. Data on curriculum approaches, teaching methods, integration of topics of interest, clinical education, staff–student ratios, access to facilities and new technologies, teaching staff (faculty) and quality assurance processes are presented for Primary Dental Degree Programmes.ConclusionTo the best of our knowledge, this series of papers are the first attempts to provide a comprehensive overview of OHP education in Europe. Results showed that the majority of European dental programmes are engaged in providing innovative and scientifically grounded education in order to develop quality future OHPs. Nevertheless, significant variability in the delivery of clinical education across the European OHP schools was notable in this dataset. A comprehensive view of the state of OHP education in Europe is not yet available but the O‐Health‐Edu data hub provides a means for all education providers in Europe to contribute data to reach this goal. It is anticipated that the data hub will be updated and built upon over time to continually establish a clearer picture of the state of OHP education in Europe.
Population links between an insectivorous bird and moths disentangled through national‐scale monitoring data
Authors: Evans Luke Christopher , Burgess Malcolm D. , Potts Simon G. , Kunin William E. , Oliver Tom H. 
Published: January 2024

AbstractInsects are key components of food chains, and monitoring data provides new opportunities to identify trophic relationships at broad spatial and temporal scales. Here, combining two monitoring datasets from Great Britain, we reveal how the population dynamics of the blue titCyanistes caeruleusare influenced by the abundance of moths – a core component of their breeding diet. We find that years with increased population growth for blue tits correlate strongly with high moth abundance, but population growth in moths and birds is less well correlated; suggesting moth abundance directly affects bird population change. Next, we identify moths that are important components of blue tit diet, recovering associations to species previously identified as key food sources such as the winter mothOperoptera brumata. Our work provides new evidence that insect abundance impacts bird population dynamics in natural communities and provides insight into spatial diet turnover at a national‐scale.
Semiautomated electric source imaging determines epileptogenicity of encephaloceles in temporal lobe epilepsy
Authors: Antal Dorin‐Cristian , Altenmüller Dirk‐Matthias , Dümpelmann Matthias , Scheiwe Christian , Reinacher Peter C. , Crihan Eliza‐Theona , Ignat Bogdan‐Emilian , Cuciureanu Iulian‐Dan , Demerath Theo , Urbach Horst , Schulze‐Bonhage Andreas , Heers Marcel 
Published: January 2024

AbstractObjectiveWe aimed to assess the ability of semiautomated electric source imaging (ESI) from long‐term video‐electroencephalographic (EEG) monitoring (LTM) to determine the epileptogenicity of temporopolar encephaloceles (TEs) in patients with temporal lobe epilepsy.MethodsWe conducted a retrospective study involving 32 temporal lobe epilepsy patients with TEs as potentially epileptogenic lesions in structural magnetic resonance imaging scans. Findings were validated through invasive intracerebral stereo‐EEG in six of 32 patients and postsurgical outcome after tailored resection of the TE in 17 of 32 patients. LTM (mean duration = 6 days) was performed using the 10/20 system with additional T1/T2 for all patients and sphenoidal electrodes in 23 of 32 patients. Semiautomated detection and clustering of interictal epileptiform discharges (IEDs) were carried out to create IED types. ESI was performed on the averages of the two most frequent IED types per patient, utilizing individual head models, and two independent inverse methods (sLORETA [standardized low‐resolution brain electromagnetic tomography], MUSIC [multiple signal classification]). ESI maxima concordance and propagation in spatial relation to TEs were quantified for sources with good signal quality (signal‐to‐noise ratio > 2, explained signal > 60%).ResultsESI maxima correctly colocalized with a TE in 20 of 32 patients (62.5%) either at the onset or half‐rising flank of at least one IED type per patient. ESI maxima showed propagation from the temporal pole to other temporal or extratemporal regions in 14 of 32 patients (44%), confirming propagation originating in the area of the TE. The findings from both inverse methods validated each other in 14 of 20 patients (70%), and sphenoidal electrodes exhibited the highest signal amplitudes in 17 of 23 patients (74%). The concordance of ESI with the TE predicted a seizure‐free postsurgical outcome (Engel I vs. >I) with a diagnostic odds ratio of 2.1.SignificanceSemiautomated ESI from LTM often successfully identifies the epileptogenicity of TEs and the IED onset zone within the area of the TEs. Additionally, it shows potential predictive power for postsurgical outcomes in these patients.
How dual language bilingual education preservice teachers draw upon and develop students' sociocultural competence
Authors: Domke Lisa M. , May Laura A. , Cerrato María A. , Sanders Elizabeth H. , Kung Melody , Bingham Gary E. 
Published: January 2024

AbstractUS dual language bilingual education (DLBE) programs have a goal to develop students' sociocultural competence, but little is known about how preservice teachers (PSTs) do this. This descriptive study involved quantitative and qualitative analysis of 82 videos of instruction and 76 lesson plans from nine Latinx PSTs placed in Spanish DLBE classrooms across 3 years. PSTs focused more on students' interests or background knowledge than specific family/community and/or cultural practices. Few lessons incorporated culturally relevant/sustaining literature. Findings help teacher educators consider contextual constraints in teacher preparation and ways to better support PSTs in recognizing and developing students' sociocultural competence.
Climate match is key to predict range expansion of the world's worst invasive terrestrial vertebrates
Authors: Du Yuanbao , Wang Xuyu , Ashraf Sadia , Tu Weishan , Xi Yonghong , Cui Ruina , Chen Shengnan , Yu Jiajie , Han Lixia , Gu Shimin , Qu Yanhua , Liu Xuan 
Published: January 2024

AbstractUnderstanding the determinants of the range expansion of invasive alien species is crucial for developing effective prevention and control strategies. Nevertheless, we still lack a global picture of the potential factors influencing the invaded range expansion across taxonomic groups, especially for the world's worst invaders with high ecological and economic impacts. Here, by extensively collecting data on 363 distributional ranges of 19 of world's worst invasive terrestrial vertebrates across 135 invaded administrative jurisdictions, we observed remarkable variations in the range expansion across species and taxonomic groups. After controlling for taxonomic and geographic pseudoreplicates, model averaging analyses based on generalized additive mixed‐effect models showed that species in invaded regions having climates more similar to those of their native ranges tended to undergo a larger range expansion. In addition, as proxies of propagule pressure and human‐assisted transportation, the number of introduction events and the road network density were also important predictors facilitating the range expansion. Further variance partitioning analyses validated the predominant role of climate match in explaining the range expansion. Our study demonstrated that regions with similar climates to their native ranges could still be prioritized to prevent the spread of invasive species under the sustained global change.
Assessment of Cryogenic Coring to Preserve Vertical Distributions of Trichloroethylene and Reaction Products in an Aquitard
Authors: Kearney Kade J. , Blount Timothy , Palmer Emma , Arvizu Rosemary , Sanford Robert , Valocchi Albert , Schaefer Charles , Werth Charles J. 
Published: January 2024

AbstractThere is not a clear understanding of the extent by which naturally occurring reactions can attenuate trichloroethene (TCE) and its daughter products within low permeability zones (LPZs), and addressing this knowledge gap requires advancement of methods to accurately measure in situ volatile chemical concentrations. In this study, a soil coring method that freezes the soil in‐situ (a.k.a., cryogenic coring) was utilized to measure depth‐discrete distributions of TCE and its volatile reaction products through a TCE‐impacted silty clay aquitard, and results were compared with those from adjacent soil cores taken using a conventional coring approach. Vertical concentration profiles of TCE, cis‐1,2‐dichloroethylene (DCE), vinyl chloride (VC), ethane, and methane were all compared between the two coring methods, and results indicate the two coring methods recovered statistically equivalent concentrations of volatiles across most depths of the fine‐grained cohesive clayey soil at the study site. Biotic reductive dechlorination was the dominant TCE reaction pathway at the site; several reduced gasses that are possible markers for abiotic reduction were detected, but their concentrations and intervals of occurrence were not sufficiently consistent to indicate whether they were from abiotic TCE reduction or unrelated biological processes. Overall, cryogenic coring yielded improved recovery of sand lenses compared to conventional coring, but offered no apparent benefits for improved recovery of TCE and its volatile reaction products in the low permeability aquitard material at the site.
Venous invasion detectable only by elastic stain shows weak prognostic value in colon cancer
Authors: Fei Linda Y N , Patel Sunil V , Popa Teodora , Boudreau Lee , Caycedo‐Marulanda Antonio , Grin Andrea , Wang Tao 
Published: January 2024

AimsLarge venous invasion (VI) is prognostically significant in colon cancer. The increased use of elastic stains by pathologists results in higher VI detection rates compared to routine stains alone. This study assesses the prognostic value of VI detected by elastic versus routine stains.Methods and resultsColon cancers resected between 2014 and 2017 underwent pathology slide review for VI. Cases without VI on routine stain were stained by elastic trichrome and re‐examined. Demographic, clinical, pathological and outcome data were gathered by retrospective review. Kaplan–Meier curves with log‐rank tests were performed for survival categorised by VI status. Cox regression was performed for multivariate analysis. Of 277 cases, 97 (35%) showed VI by routine stain alone, with an additional 58 (21%) discovered by subsequent elastic stains. Thus, elastic trichrome increased VI detection by 60%. However, only VI detected by routine stain showed worse overall survival (P < 0.001). VI detected by elastic stain only was not prognostically different from cases without VI (P = 0.428). For stage 2 cancers, VI was not prognostically significant regardless of method of detection. For stage 3 cases, only VI detected by routine stain was prognostic for overall survival (P = 0.002) with a hazard ratio of 4.04 by multivariate regression (P = 0.028).ConclusionsVI detectable only by elastic stains do not show prognostic significance for survival in colon cancer. For pathologists with high baseline VI detections rates on routine stain, reflexive use of elastic stain may be of limited value.