bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disconnected: Electronic Patient-Reported Outcome Measure Collection in Orthopaedic Patients is Less Successful Than In-Person Collection at an Urban Safety Net Trauma Center
Authors: Tucker Nicholas J. , Shah Ananya , Mauffrey Cyril , Hammerberg E. Mark , Parry Joshua A. 
Published: October 2023

Objectives:
Electronic patient-reported outcome measure (E-PROM) collection is a technological advancement that has the potential to facilitate PROM collection in orthopaedic trauma. The purpose of this study was to compare E-PROM versus in-person PROM collection.

Design:
This is a retrospective comparative study.

Setting:
Urban Level I trauma center.

Patients/Participants:
One hundred and fifty consecutive operative orthopaedic trauma patients.

Intervention:
The Percent of Normal single assessment numerical evaluation and patient-reported outcomes measurement information system physical function were collected through automated e-mails from an online patient-engagement platform (PatientIQ, Chicago, IL) 2-week, 6-week, 3-month, and 6-month postoperatively. The Percent of Normal was also administered to patients in clinic at the same time intervals.

Main Outcome Measurements:
Completion of PROMs; Loss to follow-up.

Results:
The median clinical follow-up time was 4 months (interquartile range: 1.3–6 months), and 42.7% (64/150) were lost to follow-up. Loss to follow-up was associated with a more disadvantaged area deprivation index [observed difference, 7.0, 95% confidence interval, 1.0 to 13.0; P = 0.01] and noncommercial/no insurance (observed difference 34.8%, confidence interval, 20.9%–45.5%; P < 0.0001). In-person PROM collection was more successful than E-PROM collection at all intervals [2-week (51.3% vs 20.7), 6-week (46.7% vs 20.0%), 3-month (50.0% vs 18.7%), and 6-month (38.0% vs 18.7%), P < 0.0001]. Patients who completed 3-month E-PROMs had longer clinical follow-up (5.2 vs. 3.0 months, P = 0.004) and a trend of being less likely to be lost to follow-up (28.6% vs 45.9%, P = 0.13).

Conclusion:
E-PROMs were less successful than in-person PROM collection in trauma patients at an urban safety net trauma center.

Level of Evidence:
Diagnostic Level III.
Use of 3D Printing Technology in Fracture Management: A Review and Case Series
Authors: Richard Raveesh D. , Heare Austin , Mauffrey Cyril , McGinley Beau , Lencioni Alex , Chandra Arjun , Nasib Vareesha , Chaiken Brian L. , Trompeter Alex 
Published: October 2023

Summary:
Three-dimensional (3D) offers exciting opportunities in medicine, particularly in orthopaedics. The boundaries of 3D printing are continuously being re-established and have paved the way for further innovations, including 3D bioprinting, custom printing refined methods, 4D bioprinting, and 5D printing potential. The quality of these applications have been steadily improving, increasing their widespread use among clinicians. This article provides a review of the current literature with a brief introduction to the process of additive manufacturing, 3D printing, and its applications in fracture care. We illustrate this technology with a case series of 3D printing used for correction of complex fractures/nonunion. Factors limiting the use of this technology, including cost, and potential solutions are discussed. Finally, we discuss 4D bioprinting and 5D printing and their potential role in fracture surgery.
Effectiveness of placing prophylactic mesh with the Sugarbaker technique via laparoscopic abdominoperineal resection for rectal cancer: 1-year results
Authors: Vinh Ngoc Truong Pham , Nguyen Thinh Huu , Le Triet Minh , Tran Huy Duc 
Published: October 2023

Abstract

Background
The aim of this study was to assess the efficacy of parastomal hernia prevention with the Sugarbaker technique via laparoscopic abdominoperineal resection for rectal cancer after a 1-year follow-up at University Medical Center in Ho Chi Minh City, Vietnam.

Materials and Methods
Prospective study. Between November 2018 and July 2022, 43 patients with low rectal cancer underwent laparoscopic abdominoperineal resection and were divided into 2 groups: study (n = 15) with prophylactic mesh placement with the Sugarbaker technique and control (n = 28). All patients were tracked for at least a year and had an abdominal computed tomography scan. The Kaplan-Meier method was used to calculate the rate of parastomal hernia after 1 year. To compare the rates of parastomal hernia in 2 groups, the log-rank test was used.

Results
This study included 43 patients, the male-to-female ratio was approximately equal to 1:1, the median age was 62 years, the youngest age was 40 years, and the oldest age was 92 years. Rectal cancer stage III was found in 41.8% of people. Neoadjuvant chemoradiotherapy was used in 27.9% of cases. The average duration of operation was 184 minutes. The average time for mesh placement was 15 minutes. The overall complication rate was 16.4%. There were no issues with mesh placement. At 1 year, the control group had a higher cumulative rate of parastomal hernia than the study group (35.7% vs 0%; log-rank test, 6.4; P = 0.01).

Conclusions
Prophylactic mesh placement with the Sugarbaker technique via laparoscopic abdominoperineal resection for rectal cancer is safe, does not increase complications, and reduces the cumulative rate of a parastomal hernia at 1 year in patients who have undergone prophylactic mesh placement.
Minimal posterior pole vitrectomy and fixing the inverted ILM flap with DisCoVisc® for macular hole: no gas or air tamponade
Authors: Liu Yajun , Jiang Feng , Chen Feifei , Liu Yuanyuan , Zhang Wenwen , Zhang Si , He Zifang , Cheng Xinxuan , Xie Zhenggao 
Published: October 2023

Abstract

Purpose:
To investigate an alternative surgical method for macular hole (MH) repair without fluid-air exchange, gas tamponade, and prone positioning.

Methods:
Eighteen eyes of 17 patients with MHs underwent minimal posterior pole vitrectomy with an inverted internal limiting membrane (ILM) flap technique. Ophthalmic viscosurgical device(OVD) was used to fix the inverted ILM flap in the balanced salt solution. No fluid-air exchange, gas tamponade, or prone positioning was needed. Follow-ups were performed at 1 day, 1 week, and the last visit (ranging from 3 to 6 months) after surgery. Optical coherence tomography (OCT) examination, intraocular pressure (IOP), and best-corrected visual acuity (BCVA) measurements were performed preoperatively and at every follow-up postoperatively.

Results:
Primary closure of the MH was observed in all 18 eyes (100%). OCT showed U-type closure in 12 eyes, V-type closure in 5 eyes, and W-type closure in 1 eye. Preoperative, postoperative 1 week, and last follow-up BCVA were 0.90 (Snellen equivalent 20/159) ± 0.31 LogMAR, 0.72 (Snellen equivalent 20/105) ± 0.33 LogMAR, and 0.48 (Snellen equivalent 20/60) ± 0.32 LogMAR, respectively. Postoperative visual acuity was significantly improved compared with preoperative values (F=19.250, P=0.000). No significant difference in IOP was found compared with preoperative values (F=1.933, P=0.168). No significant complications were observed.

Conclusion:
This surgical method can effectively close MHs, improve visual acuity, enhance surgical efficiency, reduce surgical complications, and improve patients' postoperative experience without the need for fluid-air exchange, gas tamponade, or prone positioning.
Hyperreflective Foci not seen as Hyperpigmentary Abnormalities on Color Fundus Photographs in Age-Related Macular Degeneration
Authors: Goh Kai Lyn , Wintergerst Maximilian W.M. , Abbott Carla J. , Hadoux Xavier , Jannaud Maxime , Kumar Himeesh , Hodgson Lauren A.B. , Guzman Gabriela , Janzen Simon , van Wijngaarden Peter , Finger Robert P. , Guymer Robyn H. , Wu Zhichao 
Published: October 2023

ABSTRACT

Purpose:
To investigate the prognostic value of quantifying optical coherence tomography (OCT)-defined hyperreflective foci (HRF) that do not correspond to hyperpigmentary abnormalities (HPAs) on color fundus photographs (CFPs) - HRF

(OCT+/CFP-)

- when considered in addition to HPA extent, for predicting late age-related macular degeneration (AMD) development. We also sought to understand the impact of HRF(OCT+/CFP-) extent on visual sensitivity.

Methods:
280 eyes from 140 participants with bilateral large drusen underwent imaging and microperimetry at baseline, and then 6-monthly for 3-years. The extent of HPAs on CFPs and HRF(OCT+/CFP-) on OCT was quantified at baseline. Predictive models for progression to late AMD, accounting for drusen volume and age, were developed using HPA extent, with and without HRF(OCT+/CFP-) extent. The association between HPA and HRF(OCT+/CFP-) extent with sector-based visual sensitivity was also evaluated.

Results:
Incorporating HRF(OCT+/CFP-) extent did not improve the predictive performance for late AMD development (P≥0.32). Increasing HPA and HRF(OCT+/CFP-) extent in each sector were independently and significantly associated with reduced sector-based visual sensitivity (P≤0.004).

Conclusions:
The addition of HRF(OCT+/CFP-) extent to HPA extent did not improve the prediction of late AMD development. HRF(OCT+/CFP-) extent was also independently associated with local reductions in visual sensitivity, after accounting for HPAs.
Ophthalmic manifestations of Whipple's disease
Authors: Rasool Nailyn 
Published: October 2023

Purpose of review
Whipple's disease is an infectious cause of uveitis that may present with nonspecific findings of intraocular inflammation, which can precede the development of neurologic symptoms and signs. Whipple's disease, then, may evade consideration in the differential diagnosis for uveitis.

Recent findings
Molecular tests can be helpful in identifying the presence of Tropheryma whipplei from ocular specimens. The application of metagenomic sequencing for ocular specimens is promising, as it offers the opportunity to identify the pathogen when suspicion for an intraocular infection is high. Whipple's disease demonstrates the ability to abrogate the host immune response, which gives some insight into its pathogenesis.

Summary
Whipple's disease should be suspected in patients who have uveitis refractory to anti-inflammatory therapy. Knowledge of this important pathogen can help direct the timely implementation of diagnostic testing.
Fifty years of pain research and clinical advances: highlights and key trends
Authors: Basbaum Allan I. , Jensen Troels S. , Keefe Francis J. 
Published: October 2023

Abstract
This article highlights advances in basic science preclinical pain research, clinical research, and psychological research occurring over the 50 years since the International Association for the Study of Pain was founded. It presents important findings and key trends in these 3 areas of pain science: basic science preclinical research, clinical research, and psychological research.
The value of the International Association for the Study of Pain to career development: perspectives of trainee and early career members
Authors: Sharma Saurab , Birnie Kathryn A. , Wang Shan , Fernandes Gomes Francisco Isaac , Gibbs Jennifer L. , Mittinty Manasi Murthy 
Published: October 2023

Abstract
Supporting its young members has been a key priority of the International Association for the Study of Pain (IASP) for the past 5 decades. The IASP, along with its federations, chapters, and special interest groups, has provided benefits to its trainee and early career members for their career development. This article summarizes various key IASP initiatives and benefits offered to IASP members and how these benefits have positively impacted their careers, including examples from the authors of this article. Suggestions are made for future directions that the IASP could implement to enhance the value provided to its trainee and early career members, which will in turn contribute to IASP achieving its mission to stimulate and support the study of pain and to translate that knowledge into improved pain relief worldwide.
The role of evolving concepts and new technologies and approaches in advancing pain research, management, and education since the establishment of the International Association for the Study of Pain
Authors: Flor Herta , Noguchi Koichi , Treede Rolf-Detlef , Turk Dennis C. 
Published: October 2023

Abstract
The decades since the inauguration of the International Association for the Study of Pain have witnessed major advances in scientific concepts (such as the biopsychosocial model and chronic primary pain as a disease in its own right) and in new technologies and approaches (from molecular biology to brain imaging) that have inspired innovations in pain research. These have guided progress in pain management and education about pain for healthcare professionals, the general public, and administrative agencies.
Future perspectives: the next fifty years of the International Association for the Study of Pain
Authors: Sommer Claudia , Calvo Margarita , Cervero Fernando , Loeser John D. 
Published: October 2023

Abstract
The International Association for the Study of Pain (IASP) has become the leading professional association dedicated to promoting pain research and management. Through its many activities, including research funding, educational programs, advocacy initiatives, and global collaborations, the Association has significantly contributed to the understanding and treatment of pain. Looking into the future, the IASP is determined to continue its mission of reducing the burden of pain on individuals and societies worldwide. Here, we explore how current and past activities of the IASP will shape the future of pain research, treatment, education, and advocacy as well as provide a valuable service to its members across the world.
A Biomarker of Stress and Self-reported Caregiving Distress Predict Poor Quality of Life in Family Caregivers of Patients With Heart Failure
Authors: Liu Ya-Ching , Chou Man-Chun , Chiang Ming-Chu , Hang Chih-Ling , Chen Shyh-Ming , Chung Misook L. , Lin Chin-Yen , Huang Tsuey-Yuan 
Published: October 2023

Background
Family caregivers are at a high risk for low quality of life due to caregiving-related stress. Caregivers' stress is commonly assessed using self-reported measures, which reflect relatively subjective and long-term stress related to caregiving, but objective biological markers of stress are rarely used for caregivers. The purposes of this study were (1) to determine whether caregiver characteristics were associated with stress assessed using a stress biomarker (serum cortisol) and a self-reported caregiving distress measure (Caregiver Burden Inventory) and (2) to determine the predictability of both stress measures for quality of life in caregivers of patients with heart failure.

Methods
Taiwanese family caregivers (N = 113; mean age, 54.5 years; 70.8% female) of patients with heart failure completed surveys including caregiving distress and quality of life measured by the Caregiver Burden Inventory and the Short Form-36 (physical and psychological well-being subscales), respectively, and provided blood samples for serum cortisol. Independent t tests, correlation, and hierarchical regression were conducted.

Results
Single caregivers had higher serum cortisol levels than married caregivers (P = .002). Men had significantly higher serum cortisol levels than women (P = .010), but men reported lower caregiving distress than women (P = .049). Both serum cortisol (β = −0.32, P = .012) and caregiving distress (β = −0.29, P = .018) were significant predictors of quality of life in the physical well-being scale while controlling for caregivers' characteristics and depressive symptoms. Serum cortisol (β = −0.28, P = .026) and caregiving distress (β = −0.25, P = .027) also predicted quality of life in the psychological well-being scale.

Conclusions
Serum cortisol and self-reported caregiving distress have similar predictability for quality of life in family caregivers of patients with heart failure. Reducing stress and caregiving distress is critical to improving quality of life in this population.
Mediation by Fatalism of the Association Between Symptom Burden and Self-care Management in Patients With Heart Failure
Authors: Thapa Ashmita , Chung Misook L. , Wu Jia-Rong , Latimer Abigail , Lennie Terry A. , Mudd-Martin Gia , Lin Chin-Yen , Thompson Jessica Harman , Kang JungHee , Moser Debra K. 
Published: October 2023

BackgroundClinicians and researchers often assume that symptom burden is associated with self-care management (SCM) in patients with heart failure (HF). However, that association is often not borne out in simple regression analyses and may be because another variable mediates the association. Fatalism is an appropriate candidate for mediation and is the belief that circumstances are predetermined without opportunity for control by individuals.ObjectiveOur objective was to determine whether fatalism mediated the relationship of symptom burden with SCM among adults with HF.MethodsWe conducted a secondary analysis (N = 95) from a clinical trial. We used Self-care of HF Index to measure SCM, the Memorial Symptom Assessment Scale-HF for symptom burden, and the Cardiovascular Disease Fatalism Instrument to measure fatalism. We used the PROCESS macro to evaluate mediation.ResultsSymptom burden was not directly associated with SCM (effect coefficient [C'] = 0.0805; 95% confidence interval, −0.048 to 0.209;P= .217). There was, however, an indirect pathway between symptom burden and SCM through fatalism (ab= −0.040; 95% confidence interval, −0.097 to −0.002). Those with higher symptom burden were more fatalistic (a= 0.004,P= .015), and greater fatalism was associated with worse SCM (b= −9.132,P= .007).ConclusionSymptom burden, not directly associated with SCM, is associated through the mediator of fatalism. Interventions to improve SCM should include strategies to mitigate fatalistic views. Self-care management interventions should focus on promoting internal locus of control or increasing perceptions of perceived control to decrease fatalism and improve engagement in self-care.
Comparative study on clinical outcomes and cost-effectiveness of chronic subdural hematomas treated by middle meningeal artery embolization and conventional treatment: a national cross-sectional study
Authors: Tong Xin , Xue Xiaopeng , Liu Aihua , Qi Peng 
Published: October 2023

Background:We compared the efficacy and cost-effectiveness of middle meningeal artery embolization (MMAE) and conventional treatment for chronic subdural hematomas (cSDH).Methods:The Nationwide Readmissions Database of 9963 patients (27.2% women) with cSDH between 2016 and 2020 was analyzed. Finally, 9532 patients were included (95,7%, treated conventionally; 4,3%, treated with MMAE). Baseline demographics, comorbidities, adverse events, treatment strategies, and outcomes were compared between patients treated with MMAE and conventional treatment. After propensity score matching (PSM), we compared primary outcomes, including 90-day treatment rate, functional outcome, length of hospital stays, and cost. A Markov model estimated lifetime costs and quality-adjusted life years (QALYs) associated with different treatments. The incremental cost-effectiveness ratio (ICER) was calculated to evaluate the base-case scenario. One-way, two-way, and probabilistic sensitivity analyses were performed to evaluate the uncertainty in the results.Results:After PSM, MMAE had a lower 90-day retreatment rate (2.6% vs. 9.0%,P= 0.001), shorter length of hospital stays (4.61±6.19 vs. 5.73±5.76 d,P=0.037), similar functional outcomes compared (favorable outcomes, 80.9% vs. 74.8%,P=0.224) but higher costs ($119757.71±90378.70 vs. $75745.55±100701.28,P<0.001) with conventional treatment. MMAE was associated with an additional cost of US$19280.0 with additional QALY of 1.3. Its ICER was US$15199.8/QALY.Conclusion:MMAE is more effective in treating cSDH than conventional treatment. Based on real-world data, though MMAE incurs higher overall costs, the Markov model showed it to be cost-effective compared to conventional treatment under the American healthcare system. These comparative and economic analyses further support the consideration of a paradigm shift in cSDH treatment.
Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multi-questionnaire survey from a large cohort
Authors: Hua Yuze , Hong Xia , Dai Menghua , Li Jiayi , Yang Sen , Guo Junchao , Wang Weibin , Xu Qiang , Han Xianlin , Wang Mengyi , Huang Nan , Zheng Huaijin , Kleeff Jorg , Liu Qiaofei , Wu Wenming , Zhang Taiping , Liao Quan , Zhao Yupei 
Published: October 2023

Background:
Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare, low-grade malignant pancreatic tumor with a highly favorable prognosis. Most SPN patients are young and middle-aged women. The main controversial topic for SPN is local resection (LR) versus radical resection (RR). Theoretically, local resection could lead to better gastrointestinal function (GIF) and less mental stress. However, no data is available to support this hypothesis.

Methods:
All SPN patients undergoing surgical treatment in XXXXXXXX Hospital from 2001 to 2021 were included in the study. A cross-sectional online multi-questionnaire survey containing 110 questions was sent to them (XXXXXXX). This online multi-questionnaire survey focused on GIF and mental stress and consisted of eight questionnaires. Multiple linear regression analysis was conducted to identify independent factors impacting GIF and mental stress.

Results:
A total of 183 cases provided valid results. Among them, 46 patients (25.1%) underwent LR, and 137 (74.9%) underwent RR. Ninety-four cases (51.4%) underwent minimally invasive surgery (MIS), while 89 (48.6%) underwent open surgery. The average GSRS score of the patients was 1.9±0.7, indicating that most suffered from mild gastrointestinal dysfunction. The scores of PHQ-9 and GAD-7 in 16 patients (8.7%) and 27 (14.8%) patients, respectively, were beyond 10.0, which indicated clinical depression and anxiety. Additionally, 19 (10.4%) patients reported poor ability to work, and 31(16.9%) patients had significant body image concerns. Compared to other clinicopathological characteristics, LR (LR vs. RR: PHQ-9 score, P=0.018; WAI average score, P=0.010; EORTC-QLQ C30, nine sub-domains, P<0.05; GSRS average score, P= 0.006) and MIS (MIS vs. open surgery: EORTC-QLQ C30, three sub-domains, P<0.05; GSRS average score, P=0.006) were the most significant factors predicting improved GIF and reduced mental stress.

Conclusions:
This study systematically presents postoperative GIF and mental stress of SPN patients using validated multi-questionnaires for the first time. It provides solid evidence that LR and MIS can improve GIF and reduce mental stress after surgery for SPN patients, which could be helpful for the surgeons to make more personalized surgical plans for their patients.