bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
Authors: Saggese Pasquale , Pandey Aparamita , Alcaraz Martín , Fung Eileen , Hall Abbie , Yanagawa Jane , Rodriguez Erika F. , Grogan Tristan R. , Giurato Giorgio , Nassa Giovanni , Salvati Annamaria , Shirihai Orian S. , Weisz Alessandro , Dubinett Steven M. , Scafoglio Claudio 
Published: November 2023

Abstract

Increased utilization of glucose is a hallmark of cancer. Sodium-glucose transporter 2 (SGLT2) is a critical player in glucose uptake in early-stage and well-differentiated lung adenocarcinoma (LUAD). SGLT2 inhibitors, which are FDA approved for diabetes, heart failure, and kidney disease, have been shown to significantly delay LUAD development and prolong survival in murine models and in retrospective studies in diabetic patients, suggesting that they may be repurposed for lung cancer. Despite the antitumor effects of SGLT2 inhibition, tumors eventually escape treatment. Here, we studied the mechanisms of resistance to glucose metabolism-targeting treatments. Glucose restriction in LUAD and other tumors induced cancer cell dedifferentiation, leading to a more aggressive phenotype. Glucose deprivation caused a reduction in alpha-ketoglutarate (αKG), leading to attenuated activity of αKG-dependent histone demethylases and histone hypermethylation. The dedifferentiated phenotype depended on unbalanced EZH2 activity that suppressed prolyl-hydroxylase PHD3 and increased expression of hypoxia-inducible factor 1α (HIF1α), triggering epithelial-to-mesenchymal transition. Finally, a HIF1α-dependent transcriptional signature of genes upregulated by low glucose correlated with prognosis in human LUAD. Overall, this study furthers current knowledge of the relationship between glucose metabolism and cell differentiation in cancer, characterizing the epigenetic adaptation of cancer cells to glucose deprivation and identifying targets to prevent the development of resistance to therapies targeting glucose metabolism.

Significance:
Epigenetic adaptation allows cancer cells to overcome the tumor-suppressive effects of glucose restriction by inducing dedifferentiation and an aggressive phenotype, which could help design better metabolic treatments.
ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma
Authors: Neri Paola , Barwick Benjamin G. , Jung David , Patton Jonathan C. , Maity Ranjan , Tagoug Ines , Stein Caleb K. , Tilmont Remi , Leblay Noemie , Ahn Sungwoo , Lee Holly , Welsh Seth J. , Riggs Daniel L. , Stong Nicholas , Flynt Erin , Thakurta Anjan , Keats Jonathan J. , Lonial Sagar , Bergsagel P. Leif , Boise Lawrence H. , Bahlis Nizar J. 
Published: November 2023

Abstract

Immunomodulatory drugs (IMiD) are a backbone therapy for multiple myeloma (MM). Despite their efficacy, most patients develop resistance, and the mechanisms are not fully defined. Here, we show that IMiD responses are directed by IMiD-dependent degradation of IKZF1 and IKZF3 that bind to enhancers necessary to sustain the expression of MYC and other myeloma oncogenes. IMiD treatment universally depleted chromatin-bound IKZF1, but eviction of P300 and BRD4 coactivators only occurred in IMiD-sensitive cells. IKZF1-bound enhancers overlapped other transcription factor binding motifs, including ETV4. Chromatin immunoprecipitation sequencing showed that ETV4 bound to the same enhancers as IKZF1, and ETV4 CRISPR/Cas9-mediated ablation resulted in sensitization of IMiD-resistant MM. ETV4 expression is associated with IMiD resistance in cell lines, poor prognosis in patients, and is upregulated at relapse. These data indicate that ETV4 alleviates IKZF1 and IKZF3 dependency in MM by maintaining oncogenic enhancer activity and identify transcriptional plasticity as a previously unrecognized mechanism of IMiD resistance.

Significance:
We show that IKZF1-bound enhancers are critical for IMiD efficacy and that the factor ETV4 can bind the same enhancers and substitute for IKZF1 and mediate IMiD resistance by maintaining MYC and other oncogenes. These data implicate transcription factor redundancy as a previously unrecognized mode of IMiD resistance in MM.
See related article by Welsh, Barwick, et al., p. 34.
See related commentary by Yun and Cleveland, p. 5.
This article is featured in Selected Articles from This Issue, p. 4
Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2
Authors: Dorey Tristan W. , Liu Yingjie , Jansen Hailey J. , Bohne Loryn J. , Mackasey Martin , Atkinson Logan , Prasai Shuvam , Belke Darrell D. , Fatehi-Hassanabad Ali , Fedak Paul W.M. , Rose Robert A. 
Published: November 2023

BACKGROUND:

β-AR (β-adrenergic receptor) stimulation regulates atrial electrophysiology and Ca
2+
homeostasis via cAMP-dependent mechanisms; however, enhanced β-AR signaling can promote atrial fibrillation (AF). CNP (C-type natriuretic peptide) can also regulate atrial electrophysiology through the activation of NPR-B (natriuretic peptide receptor B) and cGMP-dependent signaling. Nevertheless, the role of NPR-B in regulating atrial electrophysiology, Ca
2+
homeostasis, and atrial arrhythmogenesis is incompletely understood.

METHODS:

Studies were performed using atrial samples from human patients with AF or sinus rhythm and in wild-type and NPR-B-deficient (NPR-B
+/−
) mice. Studies were conducted in anesthetized mice by intracardiac electrophysiology, in isolated mouse atrial preparations using high-resolution optical mapping, in isolated mouse and human atrial myocytes using patch-clamping and Ca
2+
imaging, and in mouse and human atrial tissues using molecular biology.

RESULTS:

Atrial NPR-B protein levels were reduced in patients with AF, and NPR-B
+/−
mice were more susceptible to AF. Atrial cGMP levels and PDE2 (phosphodiesterase 2) activity were reduced in NPR-B
+/−
mice leading to larger increases in atrial cAMP in the presence of the β-AR agonist isoproterenol. NPR-B
+/−
mice displayed larger increases in action potential duration and L-type Ca
2+
current in the presence of isoproterenol. This resulted in the occurrence of spontaneous sarcoplasmic reticulum Ca
2+
release events and delayed afterdepolarizations in NPR-B
+/−
atrial myocytes. Phosphorylation of the RyR2 (ryanodine receptor) and phospholamban was increased in NPR-B
+/−
atria in the presence of isoproterenol compared with the wildtypes. C-type natriuretic peptide inhibited isoproterenol-stimulated L-type Ca
2+
current through PDE2 in mouse and human atrial myocytes.

CONCLUSIONS:
NPR-B protects against AF by preventing enhanced atrial responses to β-adrenergic receptor agonists.
Using Paleoclimate Analogues to Inform Climate Projections
Authors: Watkins Aja 
Published: November 2023

Abstract
Philosophers of science have paid close attention to climate simulations as means of projecting the severity and effects of climate change, but have neglected the full diversity of methods in climate science. This paper shows the philosophical richness of another method in climate science: the practice of using paleoclimate analogues to inform our climate projections. First, I argue that the use of paleoclimate analogues can offer important insights to philosophers of the historical sciences. Rather than using the present as a guide to the past, as is common in the historical sciences, paleoclimate analogues involve using the past as a guide to the future. I thereby distinguish different methods in the historical sciences and argue that these distinctions bear on debates over whether the historical sciences can produce generalizations or predictions. Second, I suggest that paleoclimate analogues might actually be considered a type of climate model, and, as such, their use expands on common characterizations of models to include those that are full-scale, naturally occurring, and non-manipulable.
A Debilitating Colonial Duration: Reconfiguring Fanon
Authors: Al-Saji Alia 
Published: November 2023

Abstract
I argue that the temporality of colonialism is a disabling duration. To elaborate, I focus on a site in Frantz Fanon’s Black Skin, White Masks where disability/debility and racism intertwine – Fanon’s refusal of “amputation” in his experience of cinema. While such disability metaphors have been problematized as ableist, I argue that amputation is more than a metaphor of lack. It extends what racializing debilitation means and makes tangible the prosthetics that colonialism imposes and the phantoms and affects of colonized life that it attempts to sever. Engaging with disability studies, especially Black and anticolonial theories, I articulate racism and (dis)ability as more than parallel or analogy and conceptualize a debilitating colonial duration, as instanced in our pandemic time. By reconfiguring the possibilities foreclosed through colonialism, I ask what routes there may be to make colonial duration hesitate and destabilize its inevitability, while dwelling with its wounds and ruptures.
Atlantic Mobilities and the Defiance of the Early Quakers
Authors: Pestana Carla Gardina 
Published: November 2023

Abstract
By the mid-1650s, the Quakers participated in an astounding campaign to spread the news of their movement. Bent on convincing everyone, they traveled through Europe, the Mediterranean, and the English Atlantic colonies. This missionary campaign was unusual in that individual converts made the decision to travel of their own accord and they did so extensively for over a decade. This travel was unstructured, even chaotic, and yet it had a major impact by spreading convincement far and wide. Quaker mobility increased the number and the spread of adherents, establishing widely scattered communities of Friends. In response to Quaker success, in the mid-1660s English authorities tried to adapt coerced transportation to rid communities of Quakers. This effort revealed a “moral economy of transportation,” in which moves to dispatch individuals were judged and, at times, resisted. Both the movement of Quakers and the efforts of officials depended upon new routes of travel and practices of coerced migration, indicative of changes in the movement of peoples that the seventeenth century witnessed.
Chinese Migration to and within Europe: Continuity and Renewal in the Light of Demographic Factors and the Impact of Covid-19
Authors: 王 思萌 
Published: November 2023

Abstract
Under the changing demographic effects of Chinese migratory waves in Europe and in the global context of the Covid-19 pandemic, Chinese migratory patterns to Europe as well as the lives of migrants and their descendants in European countries have been renewed since the 2010s, both in material and symbolic or emotional ways. This special issue includes five articles shedding new light on the patterns of Chinese migration to Europe, and on the dynamics of their everyday lives in and beyond the European countries. As the special issue editor, I first argue that Chinese overseas, as an important part of global China, offer a privileged site of study for understanding Chinese society from inside and outside. Then, based on the literature review on Chinese migration to and within Europe from the 1980s to post-2020, I introduce specificities of contemporary Chinese migration to Europe and the Chinese presence in European countries, and highlight four main demographic features: the growth in the population of descendants, the aging of the first-generation migrants, the massive arrival of students and skilled migrants, and the feminization of migration. Thirdly, I provide an overview of the five articles included in this special issue. Finally, I conclude the introduction by underlying the contributions of this volume, the theoretical frameworks that they borrow and consolidate, and new avenues for research opened up by this special issue.
The Impact of International Education and Cultural Empowerment in the Global Job Market
Authors: Astarita Claudia 
Published: November 2023

Abstract
This article challenges the idea that international education only has positive spillover effects on the students going through it, assessing students’ capacity to understand and, if possible, explore new working opportunities in the host country. It discusses to what extent an international education experience and regular exposure to an alternative educational, social, and working environment could provide opportunities for students to broaden and deepen their views and perceptions of the world, and to use cultural capital gained from international mobility to increase their employability in the global job market.
Based on a study conducted among a small group of Chinese students based in France, this article highlights when, how, and under which circumstances students’ mobility capital is understood and explored as a new source of economic opportunities, discussing motivations and integration in the experiences of Chinese international students.
The Local and Global Scope of The Year of the Ox
Authors: Lamas-Abraira Laura , Vilarrasa Alba Colombo 
Published: November 2023

Abstract
The arrival of the Covid-19 pandemic brought significant life changes and acted as a point of rupture for many people around the world. Using mixed methods research, this article explores how the pandemic scenario affected the organization and conceptualization of the Chinese New Year Festival in Barcelona, as well as how people participated in the festivities. Having been canceled in 2020, when everything was ready to go in 2021, its transition to a virtual event entailed changes in its format, content, and scope, leading to new synergies and ways of understanding the festival. First, the virtual format enabled the participation of new actors within and beyond the Chinese diaspora, resulting in a shift of visibility. Second, new (non-folkloric) spaces for participation served to diversify the esthetics, aims and scope of the festival, with the global economic crisis and its local impacts as key factors. Finally, while the virtual format limited the festival’s local impact, it stimulated new transnational dynamics and facilitated an increase in the number of global attendees.
Migration of ‘Somebody’s Children’: Entangled Histories of Motherhood through Chinese Adoption in the United States in the 1990s
Authors: Zhang Alice (Yang) 
Published: November 2023

Abstract
This article examines the entanglement of Chinese and American motherhood through Chinese adoption in the United States in the 1990s, during what Sino-American relations scholars frame as ‘the Long Cold War era’. The Long Cold War era refers to a long durée view of the structural Cold War derivatives in Asia that defies the linear and neat Cold War periodisation from 1947 to 1991. From the 1990s to 2015, Chinese ‘revolutionary motherhood’ and American ‘fortressed motherhood’ intertwined through the adoption of Chinese children into American families. Such enmeshment challenged the conventional narratives on international adoption as either a site of exploitation or paternalistic salvation towards transnational and transracial adoptees. By centring the lived experiences of mothers in both countries, this article employs mothers’ first-person accounts to interrogate the gendered politics of Chinese adoption, complicating the simplistic narrative of passive female victimhood in family settings.
Turning Public Opinion on Immigration: the British Conservative Party and the Expulsion of Ugandan Asians in 1972
Authors: Hansen Randall 
Published: November 2023

Abstract
This article examines the Ugandan Asians’ crisis of 1972, during which President Idi Amin expelled tens of thousands of Asian nationals from the country. It explains why Ugandan Asians held, against expectations and the UK government’s intention, British citizenship. Drawing on primary sources and the social science literature on ‘framing’, the article then explores how Britain’s Conservative government secured the support of an initially hostile public for its decision to allow the Asians entry to the United Kingdom. It argues that the Conservatives succeeded by framing the Ugandan Asians as middle-class, hard-working, skilled refugees, rather than as immigrants or British citizens, and Idi Amin as a murderous monster. The press played a vital role in the government’s success. The article ends by reflecting on the case’s implications for contemporary British immigration policy and the capacity of the state to generate support for open immigration.
Korea’s Country Partnership Strategy and Bilateral Trade: Establishing a Nexus in Sub-Saharan Africa
Authors: Katoka Ben 
Published: November 2023

Abstract
Is the establishment of Korea’s Country Partnership Strategy (CPS) since 2011 associated with increases in Korea’s exports to and imports from its Sub-Saharan African (SSA) partners? Two cases of Korea’s CPS for SSA countries — Ethiopia and Mozambique — indicate that an association can be established between the CPS inception and increases in Korea’s exports of manufactured products to and imports of primary commodities from its priority partners. At the same time, the study revealed that improvement in the trade balance in favor of the priority partners depended on the type of primary commodities in which those countries specialize. Specifically, priority partners specializing in minerals exports experienced a dramatic improvement in their trade balance with Korea relative to their counterparts specializing in agricultural exports.
Multilingual and Multicultural Childhood: Robin Ha’s Almost American Girl
Authors: Dong Lan 
Published: November 2023

Abstract
Robin Ha’s Almost American Girl (2020) visualizes the narrator’s childhood in South Korea and the United States through a multilingual and multimodal lens. Taking advantage of comics’ unique formal properties, Ha’s work situates the narrator’s memories and experiences as a teen immigrant at the nexus of Korean, English, and visual languages. This article examines how Ha’s book addresses social discrimination, linguistic hybridization, and intertextual cross-cultural encounters, while telling a coming-of-age story. It discusses how Ha utilizes colors and symbols to map the young narrator’s struggles with language barriers; how her book dismantles linguistic walls and highlights the fluidity between languages and cultures; and how it blurs the boundaries among lived experiences, memories, and the fantasy world of comics. Overall, Ha’s “expansive visual vernacular” (Miller “Innovative Autobiography,” 6) helps the narrator navigate challenges as she learns English and guides the reader through a multilingual and multicultural landscape.
Atiq Rahimi’s Exophonic Entanglements: Multilingual and Multimodal Poetics
Authors: Amiri Lida 
Published: November 2023

Abstract
In 2008, first-generation Afghan migrant novelist-artist Atiq Rahimi published his first translingual work in French, Syngué Sabour: Pierre de patience. This article interrogates his multilingual and multimodal aesthetics across his translingual oeuvre. In his exophonic novel Les Porteurs d’eau (2019), Rahimi valorizes a polyvocal and culturally diverse Central Asian history. The Prix Goncourt–awarded author introduces Afghanistan’s past and present beyond its intracultural challenges. The epitome of the Rahimi-esque aesthetic is the author’s publication L’Invité du miroir (2020), which acts as a revolt, a transnational dialectic crossroads where multilingual fiction meets classical Persian calligraphy and nonfiction to explore the human spirit.
The Women’s and Feminist Movements’ Role in National Protest: a Comparative Case Study of Colombia, Ecuador, and Chile
Authors: Macías Andrea Guillem , Ledesma Pamela 
Published: November 2023

Abstract
Colombia, Ecuador and Chile went through a wave of social protest during 2019 and then during 2021 and 2022. Evident in the revolt was the construction of a new feminist political subject that made visible new repertoires of action, both in the street and in the spaces of reproduction of the protest. The article explores the strategies deployed by women’s and feminist movements in these three countries. It first contextualizes the development of the movement in each country in order to understand its complexities, disputes and traditions. Then, from a comparative perspective, it takes stock of the contribution of women and feminisms in scenarios of social revolt and how these strategies were key to subsequent electoral scenarios.
The article gathers the voices of feminist activists, politicians and women who played key roles during the protest interviewed in Santiago, Bogota and Quito.
On the Reliability of L
Authors: Hagewood Lee 
Published: November 2023

Abstract
This article examines the historicity of Luke 13:10–17 and 14:1–6, both of which contain healing miracles of Jesus attested only in Luke. The article proceeds by first considering the coherence of these pericopes with material widely accepted as reflecting activity of the historical Jesus. Details within these pericopes are then examined for their potential historical significance. Finally, common objections to historicity are considered. Although the evidence for these singly attested healings is incapable of ‘proving’ their historicity, it suggests that Luke’s source for these healings contains historical information that he handled no more or less responsibly than he handled Mark.
Verbum Imaginis Dei
Authors: Torseth Robb 
Published: November 2023

Abstract
After the Enlightenment turn to the subject, various problems concerning the nature of theological articulation on the one hand and the grounds for divine revelation on the other have come to the forefront, often gravitating toward questions concerning language itself. These questions tend to revolve around the nature of God’s infinite qualitative difference, noting difficulties concerning both the capacity of finite language to express the infinite, as well as the claim that the immaterial and transcendent God ‘speaks’. It will be the contention of this article that Augustine’s theology of speech can address these debates in a unique way, establishing a primarily theological model where human language itself is related to the Triune God via the imago Dei. This article will analyze Augustine’s designative theory in balance with his theological anthropology and theology of language, synthesizing them to respond to the philosophical questions of theological and divine speech. It will be posited that an Augustinian approach allocates primacy to the Trinitarian relationship between Word and word in the human person as imago Dei, which redefines both the nature and telos of language itself as a theological and truth-bearing reality. The article will conclude with an example from Dutch theologian Herman Bavinck, who implemented this Augustinian approach in the context of modern philosophy and theology.
Stationed at the Gateway
Authors: Berends Candis 
Published: November 2023

Abstract
As a missionary with the Church Missionary Society, Claud Field lived and worked in Peshawar between the years of 1892 and 1903. At the time, Peshawar was a geopolitically sensitive and missionally strategic city, and subsequent to Field’s missionary years there, he began writing and translating publications relating to the history of mission, the Afghan people and culture, notable figures of Islamic history, and Christian-Muslim relations. However, Field is little known today. This research introduces Field and a historical puzzle regarding his shift in tone, reviews his first five published books, analyses the import of the books for his time, offers an explanation to the historical puzzle, and concludes with a call for further research into Field’s life and publications. These findings help to begin filling the gap of historical research and literary criticism of Field’s corpus of works.