bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced optoelectronic properties with aromatic bridges: A computational study on N‐methyl pyridinium and phenolate types of push‐pull zwitterions
Authors: Pant Divya , Sitha Sanyasi 
Published: January 2024

AbstractA series of zwitterions with varying bridges, connecting N‐methyl pyridinium acceptor, with phenolate donor, are investigated using various methodologies like, HF, B3LYP, CAM‐B3LYP and ωB97xD. In this systematic study effects of various mono aromatic rings as bridges, on the response properties like, the dipole moments (μ), polarizabilities (α), hyperpolarizabilities (β) and adiabatic absorptions were analyzed using CPHF and TDDFT (or TDHF) theories. Compared to many traditional bridges, as well as without a bridge, enhanced nonlinear optical (2ND order NLO) responses were observed for these aromatically bridged zwitterions (with benzene ring as bridge ~5.3 times and ~7.9 times enhanced hyperpolarizabilities were observed compared to either the ethylene bridge or without any bridge cases, respectively). Also, many significant differences and large enhancements in response properties were observed compared to our earlier works on non‐zwitterionic system (~4.3 times enhanced hyperpolarizability—benzene as bridge case). For some bridge cases, 10‐ to 15‐fold enhanced hyperpolarizabilities were observed compared to without any bridge case. This work reports a class of non‐TICT chromophores, promoting bridge aromaticity control on structure–property correlation, as a suitable and efficient chromophore design strategy to create a wide range of function molecular chromophores. Also, unidirectional natures of response properties and large dipole moments can make these zwitterions suitable 1D‐molecular materials for various contemporary technological applications, as poled polymer‐based materials.
Decentralized model reference adaptive control for interconnected systems with time‐varying delays and unknown dead‐zone inputs
Authors: Yang Chen , Xu Shengyuan , Zhang Zhengqiang 
Published: January 2024

AbstractIn this study, the decentralized model reference adaptive control (DMRAC) problem is tackled for a class of time‐varying delay interconnect systems that comprise unknown system matrices and unknown dead‐zone inputs. Two robust adaptive control methods are proposed for state tracking based on the moderate matching time‐varying delay nonlinear assumptions and the matching between the controlled system and reference model matrices, respectively. The control gain function is explicitly expressed, and it is applied to the adaptive law gains simultaneously. Moreover, a Lyapunov–Krasovskii functional with two integral functions is developed. Besides the properties of the type‐B Nussbaum function, the circumstance where the system parameters are fully unknown is considered. As indicated by the results, all signals in the closed‐loop system are bounded while fulfilling asymptotically tracked control objectives. The simulation example of this study verifies the effectiveness and feasibility of the proposed design method.
Associations among posttraumatic stress disorder symptoms, suicidal ideation, suicide attempts, and reward discounting
Authors: McManimen Stephanie L. , Hay Jarrod , Long Cameron , Bryan Craig J. , Aase Darrin M. 
Published: January 2024

AbstractPosttraumatic stress disorder (PTSD) is associated with suicidal thoughts and behaviours. Decision‐making processes and risk‐taking are prominent for coping in both, but the implications for guaranteed and probabilistic reward discounting, important components in behavioural decision‐making processes, are unclear. This study explored the relationships between PTSD and suicide risk with tendencies towards devaluing guaranteed rewards that are larger but delayed (i.e., delay discounting; DD) and devaluing larger but uncertain rewards (i.e., probability discounting; PD) for immediate but smaller rewards. The current study evaluated 498 participants (majority male [51.4%] and white [63.8%]; 33.3% screening positive for probable PTSD; 19.2% with lifetime suicide attempts; 30.8% with recent suicide ideation) on both delayed discounting and PD tasks. Provisional PTSD diagnosis, but not suicide attempts or ideation, was associated with increased PD (i.e., more devaluation of uncertain rewards). Conversely, PTSD interacted with both attempt history and ideation to predict increased delayed discounting (i.e., more devaluing of greater but delayed rewards). These results highlight how those with PTSD symptoms assign valuations to rewards, as well as how the addition of suicide risk interacts to impact these decision‐making processes. While further research is needed, this suggests potential implications for treatment as they may benefit from structuring progress in smaller, more immediate goals.
Dual Activation for Tuning N, S Co‐Doping in Porous Carbon Sheets Toward Superior Sodium Ion Storage
Authors: Zhang Dingyue , Zhang Hao , Gao Fan , Huang Gang , Shang Zhoutai , Gao Caiqin , Chen Xianchun , Wei Jingjiang , Terrones Mauricio , Wang Yanqing 
Published: January 2024

AbstractPorous carbon has been widely focused to solve the problems of low coulombic efficiency (ICE) and low multiplication capacity of Sodium‐ion batteries (SIBs) anodes. The superior energy storage properties of two‐dimensional(2D) carbon nanosheets can be realized by modulating the structure, but be limited by the carbon sources, making it challenging to obtain 2D structures with large surface area. In this work, a new method for forming carbon materials with high N/S doping content based on combustion activation using the dual activation effect of K2SO4/KNO3 is proposed. The synthesized carbon material as an anode for SIBs has a high reversible capacity of 344.44 mAh g−1 at 0.05 A g−1. Even at the current density of 5 Ag−1, the capacity remained at 143.08 mAh g−1. And the ICE of sodium‐ion in ether electrolytes is ≈2.5 times higher than that in ester electrolytes. The sodium storage mechanism of ether/ester‐based electrolytes is further explored through ex‐situ characterizations. The disparity in electrochemical performance can be ascribed to the discrepancy in kinetics, wherein ether‐based electrolytes exhibit a higher rate of Na+ storage and shedding compared to ester‐based electrolytes. This work suggests an effective way to develop doubly doped carbon anode materials for SIBs.
A Mott–Schottky Heterojunction with Strong Chemisorption and Fast Conversion Effects for Room‐Temperature Na–S Batteries
Authors: Wang Ting , Li Wenqi , Fu Yujun , Wang Dongjiao , Wu Liang , Sun Kai , Liu Dequan , Ma Runze , Shi Yujie , Yang Gang , Wu Ying , He Deyan 
Published: January 2024

AbstractThe practical application of the room‐temperature sodium–sulfur (RT Na–S) batteries is currently limited by low reversible capacity and serious capacity decay due to the sluggish reaction kinetics and shuttle effect. It is necessary to design a suitable sulfur host integrated with electrocatalysts to realize effective chemisorption and catalysis of sodium polysulfides (NaPSs). Herein, under the guidance of theoretical calculation, the Mott–Schottky heterojunction with a built‐in electric field composed of iron (Fe) and iron disulfide (FeS2) components anchored on a porous carbon matrix (Fe/FeS2‐PC) is designed and prepared. The enhanced chemisorption effect of Fe, the fast electrocatalytic effect of FeS2, and the fast transfer effect of the built‐in electric field within the Fe/FeS2 heterojunction in the cathode of RT Na–S batteries work together to effectively improve the electrochemical performance. As a result, the Fe/FeS2‐PC@S cathode exhibits high reversible capacity (815 mAh g−1 after 150 cycles at 0.2 A g−1) and excellent stability (516 mAh g−1 after 600 cycles at 5 A g−1, with only 0.07% decay per cycle). The design of the Fe/FeS2 heterojunction electrocatalyst provides a new strategy for the development of highly stable RT Na‐S batteries.
RETRACTED: Integrated RNA expression and alternative polyadenylation analysis identified CPSF1‐CCDC137 oncogenic axis in lung adenocarcinoma
Authors: Xudong Xiang , Heng Li , Benchao Chen , Wenjie Chen , Bao Lei , Gaofeng Li 
Published: January 2024

AbstractThis study aims to analyze the RNA expression and alternative polyadenylation (APA) events and identify APA tuned genes with prognostic significance in lung adenocarcinoma (LUAD). Genome‐wide RNA expression profile and APA events were acquired in LUAD cancer and normal samples in GSE197346. Comparative analysis screened common deregulated genes and transcripts. All 11 and 19 transcripts were up and down expressed and polyadenylated in cancer samples, respectively. Clinical analysis found eight genes with prognostic significance, such as coiled‐coil domain containing 137 (CCDC137). Role of CCDC137 in LUAD was first reported in this study. The cellular and animal experiments indicated that downregulated CCDC137 suppressed the malignant tumor phenotype and tumor growth in LUAD. Then, to identify APA regulators for elevated CCDC137, we analyzed the expression of 26 APA regulators in GSE197346 and The Cancer Genome Atlas (TCGA), and found 4 differential regulators: CPSF1, CELF2, NUDT21, and ELAVL1. At last, the correlation of eight genes with four differential APA regulators was analyzed, and CPSF1 showed a strong positive correlation with CCDC137. Based on the above results, we propose an oncogenic axis of CPSF1‐CCDC137 in LUAD. This study first constructed a polyadenylation tuned RNA expression map in LUAD, and the proposed oncogenic axis of CPSF1‐CCDC137 would shed light on the pathogenesis of LUAD.
Epstein‐Barr virus in tonsillar tissue of Iranian children with tonsillar hypertrophy: Quantitative measurement by real‐time PCR
Authors: Kalantari Shirin , Zadheidar Sevrin , Heydarifard Zahra , Nejati Ahmad , Sadeghi Kaveh , Shatizadeh Malekshahi Somayeh , Ghavami Nastaran , Mokhtari‐Azad Talat , Shafiei‐Jandaghi Nazanin‐Zahra 
Published: January 2024

AbstractBackground and ObjectivesEpstein‐Barr virus (EBV) infection is ubiquitous all around the world. Tonsils seem to be candidate replication sites for EBV, and these tissues can be infected acutely or chronically. Some studies reported an association between EBV infection and tonsillar hypertrophy. In this study, we aimed to evaluate the presence and copy number of the EBV genome in tonsil tissue specimens of patients with tonsillar hypertrophy.MethodsA cross‐sectional study was performed on 50 fresh tonsil tissue samples from children, who underwent tonsillectomy because of tonsillar hypertrophy. Patients' tonsil tissues were evaluated using real‐time polymerase chain reaction for EBV genome and viral load. Finally, the results were analyzed using SPSS software.ResultsEBV genome was detected in 58% (29/50) of tonsillar tissues. The relationship between EBV genome detection rate and age groups was in the statistical significance range (P = 0.051). Among 29 positive cases, the average EBV viral load was (3.1 × 105) copy/g ± (0.5 × 105) copy/g. No significant difference was observed among different sex and age groups for EBV viral load.ConclusionHerein, EBV genome detection could support the colonization of EBV in the tonsils, which may have a direct or indirect association with the pathogenesis of tonsillar hypertrophy.
The Marine Carbon Footprint: Challenges in the Quantification of the CO2 Uptake by the Biological Carbon Pump in the Benguela Upwelling System
Authors: Rixen Tim , Lahajnar Niko , Lamont Tarron , Koppelmann Rolf , Martin Bettina , Meiritz Luisa , Siddiqui Claire , Van der Plas Anja K. 
Published: January 2024

AbstractQuantifying greenhouse gas (GHG) emissions is essential for mitigating global warming, and has become the task of individual countries assigned to the Paris agreement in the form of National Greenhouse Gas Inventory Reports (NIR). The NIR informs on GHG emissions and removals over national territory encompassing the 200-mile Exclusive Economic Zone (EEZ). However, apart from only a few countries, who have begun to report on coastal ecosystems, mostly mangroves, salt marshes, and seagrass meadows, the NIR does not cover or report on GHG sources and sinks of the 200-mile exclusive economic zone which, for Namibia and South Africa includes the Benguela Upwelling System (BUS). Based on our results, we estimated a CO2 uptake by the biological carbon pump of 18.5 ± 3.3 Tg C year−1 and 6.0 ± 5.0 Tg C year−1 for the Namibian and South African parts of the BUS, respectively. Even though it is assumed that the biological carbon pump already responds to global change and fisheries, uncertainties associated with estimates of the CO2 uptake by the biological carbon pump are still large and hamper a thorough quantification of human impacts on the biological carbon pump. Despite these uncertainties, it is suggested to include parameters such as preformed nutrient supply, carbon export rates, Redfield ratios, and CO2 concentrations measured at specific key sites into the NIR to stay focussed on the biological carbon pump and to support research addressing open questions, as well as to improve methods and observing concepts.
Extensions of a scale-separated AdS4 solution and their mass spectrum
Authors: Andriot David , Tringas George 
Published: January 2024

Abstract
We consider two extensions of the so-called DGKT solution, a 4d scale-separated anti-de Sitter (AdS) solution obtained as a compactification on a 6d torus orbifold. Each extension consists in a specific large n expansion beyond the DGKT solution, where n is the unbounded F4-flux parameter. One of the extensions considered generalizes the known warped, partially backreacted solution. We analyse the two extensions in 10d massive type IIA supergravity as well as in a 4d effective theory, using a general warped compactification formalism, including axions. On top of known corrections to DGKT, we mainly get new ones from F4; other fluxes are very constrained by flux quantization. In each extension, one would expect corresponding corrections to the mass spectrum, before reaching contributions from α′-corrections. But the mass spectrum turns out to be robust, and conformal dimensions remain unchanged.
Dyonic black strings and the charge lattice in Salam-Sezgin model
Authors: Ma Liang , Pang Yi , Lü H. 
Published: January 2024

Abstract
We obtain a class of dyonic black string solutions in 6D Salam-Sezgin model. We then calculate various thermodynamic quantities associated with this solution. Interestingly, for the thermodynamic quantities to be well defined, the temperature is bounded from above. However, the mass and entropy can still grow without any upper bound, reaching infinity at the maximal temperature. The quantization condition obeyed by various charges is also analyzed. In particular, we find that the Dirac quantization condition selects one particular sign choice for the magnetic string charges.
AdS3/RMT2 duality
Authors: Di Ubaldo Gabriele , Perlmutter Eric 
Published: January 2024

Abstract
We introduce a framework for quantifying random matrix behavior of 2d CFTs and AdS3 quantum gravity. We present a 2d CFT trace formula, precisely analogous to the Gutzwiller trace formula for chaotic quantum systems, which originates from the SL(2, ℤ) spectral decomposition of the Virasoro primary density of states. An analogy to Berry’s diagonal approximation allows us to extract spectral statistics of individual 2d CFTs by coarse-graining, and to identify signatures of chaos and random matrix universality. This leads to a necessary and sufficient condition for a 2d CFT to display a linear ramp in its coarse-grained spectral form factor.Turning to gravity, AdS3 torus wormholes are cleanly interpreted as diagonal projections of squared partition functions of microscopic 2d CFTs. The projection makes use of Hecke operators. The Cotler-Jensen wormhole of AdS3 pure gravity is shown to be extremal among wormhole amplitudes: it is the minimal completion of the random matrix theory correlator compatible with Virasoro symmetry and SL(2, ℤ)-invariance. We call this MaxRMT: the maximal realization of random matrix universality consistent with the necessary symmetries. Completeness of the SL(2, ℤ) spectral decomposition as a trace formula allows us to factorize the Cotler-Jensen wormhole, extracting the microscopic object ZRMT(τ) from the coarse-grained product. This captures details of the spectrum of BTZ black hole microstates. ZRMT(τ) may be interpreted as an AdS3 half-wormhole. We discuss its implications for the dual CFT and modular bootstrap at large central charge.
Radiation from a gluon-gluino colour-singlet dipole at N3LO
Authors: Chen Xuan , Jakubčík Petr , Marcoli Matteo , Stagnitto Giovanni 
Published: January 2024

Abstract
We compute the quantum chromodynamics (QCD) corrections to the decay of a neutralino to gluinos and partons at next-to-next-to-next-to-leading order (N3LO) in the strong coupling constant αs, integrated separately over the phase-space of two, three, four or five particles in the final state. The resulting matrix elements are related to the quark-gluon antenna functions, completing the set of integrated antenna functions in final-final kinematics required for the extension of the antenna subtraction scheme to N3LO. For a model with massless partons (quarks and gluons) and an arbitrary number of adjoint fermions, we obtained the following new results to $$ \mathcal{O}\left({\alpha}_s^3\right) $$
O

α
s
3

: the inclusive cross section for the decay of a neutralino, the renormalization of the effective coupling of a neutralino to a gluino and gluon(s), the gluino collinear anomalous dimension, the gluino contribution to the parton collinear anomalous dimensions and the neutralino-gluino-gluon(s) vertex form factors. A special case of this model is the $$ \mathcal{N} $$
N
= 1 super Yang-Mills theory, where we can relate some of our findings to known results.
An outer approximation algorithm for generating the Edgeworth–Pareto hull of multi-objective mixed-integer linear programming problems
Authors: Bökler Fritz , Parragh Sophie N. , Sinnl Markus , Tricoire Fabien 
Published: January 2024

AbstractIn this paper, we present an outer approximation algorithm for computing the Edgeworth–Pareto hull of multi-objective mixed-integer linear programming problems (MOMILPs). It produces the extreme points (i.e., the vertices) as well as the facets of the Edgeworth–Pareto hull. We note that these extreme points are the extreme supported non-dominated points of a MOMILP. We also show how to extend the concept of geometric duality for multi-objective linear programming problems to the Edgeworth–Pareto hull of MOMILPs and use this extension to develop the algorithm. The algorithm relies on a novel oracle that solves single-objective weighted-sum problems and we show that the required number of oracle calls is polynomial in the number of facets of the convex hull of the extreme supported non-dominated points in the case of MOMILPs. Thus, for MOMILPs for which the weighted-sum problem is solvable in polynomial time, the facets can be computed with incremental-polynomial delay—a result that was formerly only known for the computation of extreme supported non-dominated points. Our algorithm can be an attractive option to compute lower bound sets within multi-objective branch-and-bound algorithms for solving MOMILPs. This is for several reasons as (i) the algorithm starts from a trivial valid lower bound set then iteratively improves it, thus at any iteration of the algorithm a lower bound set is available; (ii) the algorithm also produces efficient solutions (i.e., solutions in the decision space); (iii) in any iteration of the algorithm, a relaxation of the MOMILP can be solved, and the obtained points and facets still provide a valid lower bound set. Moreover, for the special case of multi-objective linear programming problems, the algorithm solves the problem to global optimality. A computational study on a set of benchmark instances from the literature is provided.
In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo–keto reductases
Authors: Bajraktari-Sylejmani Gzona , Oster Julia Sophie , Burhenne Jürgen , Haefeli Walter Emil , Sauter Max , Weiss Johanna 
Published: January 2024

AbstractThe most important dose-limiting factor of the anthracycline idarubicin is the high risk of cardiotoxicity, in which the secondary alcohol metabolite idarubicinol plays an important role. It is not yet clear which enzymes are most important for the formation of idarubicinol and which inhibitors might be suitable to suppress this metabolic step and thus would be promising concomitant drugs to reduce idarubicin-associated cardiotoxicity. We, therefore, established and validated a mass spectrometry method for intracellular quantification of idarubicin and idarubicinol and investigated idarubicinol formation in different cell lines and its inhibition by known inhibitors of the aldo–keto reductases AKR1A1, AKR1B1, and AKR1C3 and the carbonyl reductases CBR1/3. The enzyme expression pattern differed among the cell lines with dominant expression of CBR1/3 in HEK293 and MCF-7 and very high expression of AKR1C3 in HepG2 cells. In HEK293 and MCF-7 cells, menadione was the most potent inhibitor (IC50 = 1.6 and 9.8 µM), while in HepG2 cells, ranirestat was most potent (IC50 = 0.4 µM), suggesting that ranirestat is not a selective AKR1B1 inhibitor, but also an AKR1C3 inhibitor. Over-expression of AKR1C3 verified the importance of AKR1C3 for idarubicinol formation and showed that ranirestat is also a potent inhibitor of this enzyme. Taken together, our study underlines the importance of AKR1C3 and CBR1 for the reduction of idarubicin and identifies potent inhibitors of metabolic formation of the cardiotoxic idarubicinol, which should now be tested in vivo to evaluate whether such combinations can increase the cardiac safety of idarubicin therapies while preserving its efficacy.
Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
Authors: Montecchi Tommaso , Nannini Giulia , De Tommaso Domiziana , Cassioli Chiara , Coppola Federica , Ringressi Maria Novella , Carraro Fabio , Naldini Antonella , Taddei Antonio , Marotta Giuseppe , Amedei Amedeo , Baldari Cosima T. , Ulivieri Cristina 
Published: January 2024

Abstract
Background
The immunosuppressive tumor microenvironment (TME) of colorectal cancer (CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence characterization of the signaling pathways driving T cell exhaustion within TME is a critical need for the discovery of novel therapeutic targets and the development of effective therapies. We previously showed that (i) the adaptor protein Rai is a negative regulator of T cell receptor signaling and T helper 1 (Th1)/Th17 cell differentiation; and (ii) Rai deficiency is implicated in the hyperactive phenotype of T cells in autoimmune diseases.

Methods
The expression level of Rai was measured by qRT-PCR in paired peripheral blood T cells and T cells infiltrating tumor tissue and the normal adjacent tissue in CRC patients. The impact of hypoxia-inducible factor (HIF)-1α on Rai expression was evaluated in T cells exposed to hypoxia and by performing chromatin immunoprecipitation assays and RNA interference assays. The mechanism by which upregulation of Rai in T cells promotes T cell exhaustion were evaluated by flow cytometric, qRT-PCR and western blot analyses.

Results
We show that Rai is a novel HIF-1α-responsive gene that is upregulated in tumor infiltrating lymphocytes of CRC patients compared to patient-matched circulating T cells. Rai upregulation in T cells promoted Programmed cell Death protein (PD)-1 expression and impaired antigen-dependent degranulation of CD8+ T cells by inhibiting phospho-inactivation of glycogen synthase kinase (GSK)-3, a central regulator of PD-1 expression and T cell-mediated anti-tumor immunity.

Conclusions
Our data identify Rai as a hitherto unknown regulator of the TME-induced exhausted phenotype of human T cells.