bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on a multi-dimensional image information fusion algorithm based on NSCT transform
Authors: Su Yuxiang , Liang Xi , Cao Danhua , Yang Zhenyu , Peng Yuanlong , Zhao Ming 
Published: January 2024

AbstractTraditional inspection cameras determine targets and detect defects by capturing images of their light intensity, but in complex environments, the accuracy of inspection may decrease. Information based on polarization of light can characterize various features of a material, such as the roughness, texture, and refractive index, thus improving classification and recognition of targets. This paper uses a method based on noise template threshold matching to denoise and preprocess polarized images. It also reports on design of an image fusion algorithm, based on NSCT transform, to fuse light intensity images and polarized images. The results show that the fused image improves both subjective and objective evaluation indicators, relative to the source image, and can better preserve edge information and help to improve the accuracy of target recognition. This study provides a reference for the comprehensive application of multi-dimensional optical information in power inspection.
Graphical Abstract
Insights into the influences of biochar on the fate and transport of pesticides in the soil environment: a critical review
Authors: Twagirayezu Gratien , Cheng Hongguang , Wu Yanyou , Lu Hongyu , Huang Shenglan , Fang Xin , Irumva Olivier 
Published: January 2024

AbstractPesticide misuse and overuse severely pollute agricultural soils, water, and crop yields, harming people and animals. This situation raises serious concerns about environmental pollution on a global scale. As an eco-friendly material for soil remediation, biochar can efficiently immobilize pesticides in the soil. Several studies have focused on the feasibility of biochar in remediating polluted soil. However, its influences during the remediation of pesticide-polluted soils remain indistinct. The present review illuminates the positive and negative influences of biochar on the dissemination of pesticides, the underlying mechanisms, the regulating factors, and critical considerations in the ongoing development of biochar for pesticide use. It also delineates the positive and negative impacts of biochar on pesticides in the soil, evaluates potential pitfalls based on recent research, and offers suggestions for prospective biochar applications crucial for remediating contaminated soil. This review reveals that the fate and types of pesticides, along with the physicochemical properties of soil and biochar types, can significantly influence the remediation of pesticide-polluted soil using biochar. Biochar has the potential to enhance the abundance of certain bacteria and the colonization of arbuscular mycorrhizal fungi, both of which play crucial roles in soil remediation. Biochar can also modify soil moisture, microbial communities, and other factors that impact the rate of pesticide degradation while simultaneously reducing other types of arbuscular mycorrhizal fungi. This review underscores the importance of thoroughly understanding the properties of biochar before its application to polluted soils. This review can serve as a basis for subsequent studies on the biochar-mediated remediation of contaminated soils.
Graphical Abstract
Multivariate analysis of pedestrian-related crashes on Vienna’s roads
Authors: Magusic Radmila 
Published: January 2024

AbstractPedestrians are the least protected traffic group when compared to other participants. When compared to moto riders (independent of engine power) they have head protection provided by helmet or vehicle metal shield along with airbag that is providing highest level of body protection for personal vehicles drivers. This vulnerable group is characterized by the high presence of very young participants whose psychological characteristics place them in a vulnerable risky subgroup. According to the police original data on crashes involving pedestrians in the town of Vienna, since 2010 there was highest number of crashes in 2012 and after slow decrease is recorded but still high in total number of crashes involving only pedestrians is an extremely worrying problem.This research is essential to address leading characterizations in crashes with the aim to answer what is current trend in crash occurrence during 2010–2020 inside Vienna municipality, and what is predicted trend. Is there significant and distinctive difference based on gender and age with specific conditions under which crashes are occurring influencing different injury degree. Multiple regression undoubtedly points fields for action in statistically based findings providing the most important answer to this research: why crashes do occur so frequently and what is leading cause of injured pedestrians. Stepwise procedure in discriminant analysis at statistically significant level shows what differentiates injured and not injured pedestrians.
Nutritional considerations for people living with a Fontan circulation: a narrative review
Authors: Clode Melanie , Tran Derek , Majumdar Avik , Ayer Julian , Ferrie Suzie , Cordina Rachael 
Published: January 2024

AbstractThe population of people living with a Fontan circulation are highly heterogenous, including both children and adults, who have complex health issues and comorbidities associated with their unique physiology throughout life. Research focused on nutritional considerations and interventions in the Fontan population is extremely limited beyond childhood. This review article discusses the current literature examining nutritional considerations in the setting of Fontan physiology and provides an overview of the available evidence to support nutritional management strategies and future research directions. Protein-losing enteropathy, growth deficits, bone mineral loss, and malabsorption are well-recognised nutritional concerns within this population, but increased adiposity, altered glucose metabolism, and skeletal muscle deficiency are also more recently identified issues. Emergencing evidence suggets that abnormal body composition is associated with poor circulatory function and health outcomes. Many nutrition-related issues, including the impact of congenital heart disease on nutritional status, factors contributing to altered body composition and comorbidities, as well as the role of the microbiome and metabolomics, remain poodly understood.
The effects of percutaneous branch pulmonary artery interventions on exercise capacity, lung perfusion, and right ventricular function in biventricular CHD: a systematic review
Authors: Joosen Renée S. , Frissen Jules P. B. , van den Hoogen Agnes , Krings Gregor J. , Voskuil Michiel , Slieker Martijn G. , Breur Johannes M. P. J. 
Published: January 2024

AbstractBackground:Branch pulmonary artery stenosis is common after surgical repair in patients with biventricular CHD and often requires reinterventions. However, (long-term) effects of percutaneous branch pulmonary artery interventions on exercise capacity, right ventricular function, and lung perfusion remain unclear. This review describes the (long-term) effects of percutaneous branch pulmonary artery interventions on exercise capacity, right ventricular function, and lung perfusion following PRISMA guidelines.Methods:We performed a systematic search in PubMed, Embase, and Cochrane including studies about right ventricular function, exercise capacity, and lung perfusion after percutaneous branch pulmonary artery interventions. Study selection, data extraction, and quality assessment were performed by two researchers independently.Results:In total, 7 eligible studies with low (n = 2) and moderate (n = 5) risk of bias with in total 330 patients reported on right ventricular function (n = 1), exercise capacity (n = 2), and lung perfusion (n = 7). Exercise capacity and lung perfusion seem to improve after a percutaneous intervention for branch pulmonary artery stenosis. No conclusions about right ventricular function or remodelling, differences between balloon and stent angioplasty or specific CHD populations could be made.Conclusion:Although pulmonary artery interventions are frequently performed in biventricular CHD, data on relevant outcome parameters such as exercise capacity, lung perfusion, and right ventricular function are largely lacking. An increase in exercise capacity and improvement of lung perfusion to the affected lung has been described in case of mild to more severe pulmonary artery stenosis during relatively short follow-up. However, there is need for future studies to evaluate the effect of pulmonary artery interventions in various CHD populations.
Human milk polyunsaturated fatty acids are related to neurodevelopmental, anthropometric, and allergic outcomes in early life: a systematic review
Authors: Mitguard Saori , Doucette Olivia , Miklavcic John 
Published: January 2024

AbstractPolyunsaturated fatty acids are critically important for newborn nutrition and in the trajectory of growth and developmental processes throughout early life. This systematic review (PROSPERO ID: CRD42023400059) critically analyzes literature pertaining to how omega-3 and omega-6 fatty acids in human milk are related to health outcomes in early life. Literature selected for the review were published between 2005 and 2020 and included assessments in healthy term children between 0 and 5 years of age. The studies reported the relation between human milk fatty acids docosahexaenoic acid (C22:6n-3, DHA), eicosapentaenoic acid (C20:5n-3, EPA), alpha-linolenic acid (C18:3n-3, ALA), arachidonic acid (C20:4n-6, AA), and linoleic acid (C18:2n-6, LA) with three domains of health outcomes: neurodevelopment, body composition, and allergy, skin & eczema. Results from the 21 studies consistently suggested better health outcomes across the three domains for infants consuming milk with higher concentrations of total n-3, DHA, EPA, and ALA. Negative health outcomes across the three domains were associated with higher levels of total n-6, AA, and LA in milk. N-3 and n-6 content of milk were related to neurodevelopmental, body composition, and allergy, skin & eczema outcomes with moderate certainty. Maternal diet impacting milk fatty acid content and fatty acid desaturase genotype modifying physiologic responses to fatty acid intake were prominent gaps identified in the review using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and GRADE approach. This research study can inform baby nutrition product development, and fatty acid intake recommendations or dietary interventions for mothers and children.
Copyright Protection for AI-Generated Works: Exploring Originality and Ownership in a Digital Landscape
Authors: GAFFAR Hafiz , ALBARASHDI Saleh 
Published: January 2024

Abstract
This research explores AI-generated originality's impact on copyright regulations. It meticulously examines legal frameworks such as the Berne Convention, EU Copyright Law, and national legislation. Rigorously analyzing cases, including Infopaq International A/S v Danske Dagblades Forening and Levola Hengelo BV v Smilde Foods BV, illuminates evolving originality and human involvement in AI creativity. The study also contemplates global perspectives, drawing from esteemed organizations such as the World Intellectual Property Organization and the European Court of Justice and exploring diverse approaches adopted by individual nations. The paper emphasizes the imperative need for legislative updates to address the challenges and opportunities of AI-generated works. It highlights the pivotal role of international collaboration and public awareness in shaping copyright policies for the AI-driven creativity era. It also offers insights and recommendations for policymakers and researchers navigating this complex terrain.
Uncertainty Analysis of the Prediction of Massive Ash Fallout From a Large Explosive Eruption at Sakurajima Volcano
Authors: Rahadianto Haris , Tatano Hirokazu , Iguchi Masato 
Published: January 2024

AbstractVolcanic ash hazards present life‐threatening dangers to populations near volcanoes during large explosive eruptions. Vulnerable infrastructures demand a comprehensive disaster risk reduction strategy to protect residents from enormous ashfall accumulations. To prepare for the next large eruption of Sakurajima volcano, authorities in Kagoshima City are developing a countermeasure plan utilizing ash dispersal prediction 24 hr before an eruption. However, the absence of large eruptions in the last century makes it challenging to confirm the accuracy of predictions for hazard area designation. To ensure established protocols are effective, uncertainties in ashfall predictions must be addressed, enabling authorities to make appropriate responses. We simulated the previous large eruption of Sakurajima volcano using multiple wind forecast lead times as historical predictions from July 2018 to December 2022. The uncertainty in prediction results was evaluated by comparing simulation outputs with validation data from the ash dispersal data set. We examined uncertainty in hazard area assignment and its variation depending on risk items, wind field states, and the influences of seasonal patterns and events. Updating ashfall predictions with improved wind forecasts reduces uncertainty for all risk items and increases the precision of identified hazard zones. Furthermore, uncertainty levels are influenced by seasonality and can shift significantly with varying wind strengths controlling ash dispersal process. Providing uncertainty information is vital for decision‐making during ash fallout events, and it is recommended to update response decisions 12 hr after the initial prediction. This study's outcomes will aid in developing better disaster risk management strategies, focusing on volcanic ash hazards.
Simulated Tree‐Grass Competition in Drylands Is Modulated by CO2 Fertilization
Authors: Verbruggen Wim , Schurgers Guy , Meunier Félicien , Verbeeck Hans , Horion Stéphanie 
Published: January 2024

AbstractInterannual variability in climatic drivers can have a strong impact on dryland ecosystem functioning globally. While interannual variations in dryland ecosystem processes are mainly driven by rainfall, other global change drivers such as CO2 fertilization and rising temperatures can play an increasingly important role for these ecosystems. Yet, the high complexity of dryland ecosystems makes it difficult to unravel the individual and interactive impacts of these different drivers. In this work we study the impacts of interannual climatic variability on the dryland ecosystems of the Sudano‐Sahel region for the period 1950–2022. By using a dynamic vegetation model (LPJ‐GUESS v4.0), we show that the year‐to‐year variability in dryland ecosystems that originates from interannual variability in rainfall is modulated by effects of CO2 fertilization, which can strongly impact woody encroachment and resource competition between vegetation types. In contrast, we found that increased temperatures had a relatively low influence at the ecosystem level. We also show that this response varies with aridity subtype, depending on the amount and type of woody cover. By untangling the impacts of climatic drivers on dryland vegetation, this study helps us to understand the different sensitivities of dryland ecosystems to climatic variability under global change.
More Frequent Abrupt Marine Environmental Changes Expected
Authors: Heinze C. , Michel C. , Torsvik T. , Schwinger J. , Tjiputra J. F. 
Published: January 2024

AbstractWe quantify an elevated occurrence of abrupt changes in ocean environmental conditions under human‐induced climate forcing using Earth system model output through a novel analysis method that compares the temporal evolution of the forcings applied with the development of local ocean state changes for temperature, oxygen concentration, and carbonate ion concentration. Through a multi‐centennial Earth system model experiment, we show that such an increase is not fully reversible after excess greenhouse gas emissions go back to zero. The increase in occurrence of regional abrupt changes in marine environmental conditions has not yet been accounted for adequately in climate impact analyses that usually associate ecosystem shifts large‐scale variability or extreme events. Estimates for remaining greenhouse gas emission targets need thus to be more conservative.
Light People: Professor Laura Na Liu
Authors: Wang Hui , Yu Cun 
Published: January 2024

EditorialThe DNA nanotechnology outlines a new chapter in biological sciences, opening a new era of scientific and technological advancements. A pioneer of DNA nanotechnology, Professor Liu from the University of Stuttgart in Germany, our latest Light People, has been working at the interface, where nanophotonics meets biology and chemistry. On the path of scientific explorations, she believes in hard working and persistency, as indicated by a line of Chinese poetry she likes, “Don’t stop chasing the wind and the moon, the spring mountain is at the end of the plain.” She is an outstanding female researcher, radiating wisdom. She is a pioneer in exploring the power of DNA nanotechnology and applying it to other disciplines. Meanwhile, she struggles with work–life balance. Apart from being determined and persistent, Prof. Liu is also introspective. One sees the brilliance of a scientist and the struggles of a mother, as Prof. Laura Na Liu explains to us her very personal “philosophy of life”.
Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma
Authors: Chien Ming-Hsien , Yang Yi-Chieh , Ho Kuo-Hao , Ding Yi-Fang , Chen Li-Hsin , Chiu Wen-Kuan , Chen Ji-Qing , Tung Min-Che , Hsiao Michael , Lee Wei-Jiunn 
Published: January 2024

AbstractThe matrix metalloprotease A disintegrin and metalloprotease with thrombospondin motifs 1 (ADAMTS1) was reported to be involved in tumor progression in several cancer types, but its contributions appear discrepant. At present, the role of ADAMTS1 in oral squamous cell carcinoma (SCC; OSCC) remains unclear. Herein, The Cancer Genome Atlas (TCGA) database showed that ADAMTS1 transcripts were downregulated in head and neck SCC (HNSCC) tissues compared to normal tissues, but ADAMTS1 levels were correlated with poorer prognoses of HNSCC patients. In vitro, we observed that ADAMTS1 expression levels were correlated with the invasive abilities of four OSCC cell lines, HSC-3, SCC9, HSC-3M, and SAS. Knockdown of ADAMTS1 in OSCC cells led to a decrease and its overexpression led to an increase in cell-invasive abilities in vitro as well as tumor growth and lymph node (LN) metastasis in OSCC xenografts. Mechanistic investigations showed that the cyclic increase in ADAMTS1-L1 cell adhesion molecule (L1CAM) axis-mediated epidermal growth factor receptor (EGFR) activation led to exacerbation of the invasive abilities of OSCC cells via inducing epithelial-mesenchymal transition (EMT) progression. Clinical analyses revealed that ADAMTS1, L1CAM, and EGFR levels were all correlated with worse prognoses of HNSCC patients, and patients with ADAMTS1high/L1CAMhigh or EGFRhigh tumors had the shortest overall and disease-specific survival times. As to therapeutic aspects, we discovered that an edible plant-derived flavonoid, apigenin (API), drastically inhibited expression of the ADAMTS1-L1CAM-EGFR axis and reduced the ADAMTS1-triggered invasion and LN metastasis of OSCC cells in vitro and in vivo. Most importantly, API treatment significantly prolonged survival rates of xenograft mice with OSCC. In summary, ADAMTS1 may be a useful biomarker for predicting OSCC progression, and API potentially retarded OSCC progression by targeting the ADAMTS1-L1CAM-EGFR signaling pathway.
MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner
Authors: Shu Jianfeng , Jiang Jinni , Wang Xiaofang , Yang Xuejie , Zhao Guofang , Cai Ting 
Published: January 2024

AbstractDNA topoisomerase II (TOP2) is an enzyme that performs a critical function in manipulating DNA topology during replication, transcription, and chromosomal compaction by forming a vital intermediate known as the TOP2-DNA cleavage complex (TOP2cc). Although the TOP2cc is often transient, stabilization can be achieved by TOP2 poisons, a family of anti-cancer chemotherapeutic agents targeting TOP2, such as etoposide (VP-16), and then induce double-strand breaks (DSBs) in cellular DNA. TOP2cc first needs to be proteolyzed before it can be processed by TDP2 for the removal of these protein adducts and to produce clean DNA ends necessary for proper repair. However, the mechanism by which TOP2βcc is proteolyzed has not been thoroughly studied. In this study, we report that after exposure to VP-16, MDM2, a RING-type E3 ubiquitin ligase, attaches to TOP2β and initiates polyubiquitination and proteasomal degradation. Mechanistically, during exposure to VP-16, TOP2β binds to DNA to form TOP2βcc, which promotes MDM2 binding and subsequent TOP2β ubiquitination and degradation, and results in a decrease in TOP2βcc levels. Biologically, MDM2 inactivation abrogates TOP2β degradation, stabilizes TOP2βcc, and subsequently increases the number of TOP2β-concealed DSBs, resulting in the rapid death of cancer cells via the apoptotic process. Furthermore, we demonstrate the combination activity of VP-16 and RG7112, an MDM2 inhibitor, in the xenograft tumor model and in situ lung cancer mouse model. Taken together, the results of our research reveal an underlying mechanism by which MDM2 promotes cancer cell survival in the presence of TOP2 poisons by activating proteolysis of TOP2βcc in a p53-independent manner, and provides a rationale for the combination of MDM2 inhibitors with TOP2 poisons for cancer therapy.
Development of macrophage-associated genes prognostic signature predicts clinical outcome and immune infiltration for sepsis
Authors: Ma Guangxin , Wu Xiaolin , Qi Cui , Yu Xiaoning , Zhang Fengtao 
Published: January 2024

AbstractSepsis is a major global health problem, causing a significant burden of disease and death worldwide. Risk stratification of sepsis patients, identification of severe patients and timely initiation of treatment can effectively improve the prognosis of sepsis patients. We procured gene expression datasets for sepsis (GSE54514, GSE65682, GSE95233) from the Gene Expression Omnibus and performed normalization to mitigate batch effects. Subsequently, we applied weighted gene co-expression network analysis to categorize genes into modules that exhibit correlation with macrophage activity. To pinpoint macrophage-associated genes (MAAGs), we executed differential expression analysis and single sample gene set enrichment analysis. We then established a prognostic model derived from four MAAGs that were significantly differentially expressed. Functional enrichment analysis and immune infiltration assessments were instrumental in deciphering the biological mechanisms involved. Furthermore, we employed principal component analysis and conducted survival outcome analyses to delineate molecular subgroups within sepsis. Four novel MAAGs—CD160, CX3CR1, DENND2D, and FAM43A—were validated and used to create a prognostic model. Subgroup classification revealed distinct molecular profiles and a correlation with 28-day survival outcomes. The MAAGs risk score was developed through univariate Cox, LASSO, and multivariate Cox analyses to predict patient prognosis. Validation of the risk score upheld its prognostic significance. Functional enrichment implicated ribonucleoprotein complex biogenesis, mitochondrial matrix, and transcription coregulator activity in sepsis, with an immune infiltration analysis indicating an association between MAAGs risk score and immune cell populations. The four MAAGs exhibited strong diagnostic capabilities for sepsis. The research successfully developed a MAAG-based prognostic model for sepsis, demonstrating that such genes can significantly stratify risk and reflect immune status. Although in-depth mechanistic studies are needed, these findings propose novel targets for therapy and provide a foundation for future precise clinical sepsis management.