bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive structure seeking dialogues
Authors: Fontaine Matthieu 
Published: February 2025

Abstract
In dialogical logic, the proof process is conceived in terms of argumentative games in which a proponent of a thesis and an opponent interact. Different levels of rules allow to define different logical contexts of argumentation. This provides to dialogical logic a genuine pluralistic dimension. In this paper, we introduce the rules of a new modal dialogical approach referred to as “Adaptive Structure Seeking Dialogues” (A-SSD). A-SSD have their roots in Structure Seeking Dialogues (SSD), on the one hand, and in adaptive logics, on the other hand. SSD are dialogues in which assumptions concerning the underlying modal frame can be introduced during the argumentative game. These are structural assumptions. A-SSD are based on a distinction of dialogical moves, between unconditional moves and conditional moves. Unconditional moves are performed without structural assumptions, whereas conditional moves are subject to the defence of further conditions imposed by these structural assumptions. These assumptions will be expressed in a hybrid modal language. This distinction yields the dialogical understanding of the adaptive logic inspired notions of lower limit dialogical logic and upper limit dialogical logic. Conditional moves always suppose a jump to a more permissive upper limit dialogical logic. It is interesting to note that we can think of A-SSD as some kind of diagrammatic-based reasoning, in relation to lattices representing the map of the different modal logics.
Burn injury–induced G-CSF secretion reduces spic+ erythroblastic island macrophages in the bone marrow and impairs medullary erythropoiesis
Authors: Noel John G , Goetzman Holly , Sengupta Satarupa , Medvedovic Mario , Seu Katie G , Gardner Jason C 
Published: February 2025

Abstract
The erythroblastic island (EBI) functions as a niche in which erythroblastic island macrophages (EBIMφs) are positioned within rings of erythroblasts, providing support and signals that orchestrate efficient erythropoiesis. We postulated burn injury impacts the EBI niche, given the nearly universal presence of anemia and inflammation in burn patients, and a divergent myeloid transcriptional signature that we observed in murine bone marrow following burn injury, in which granulocyte colony-stimulating factor (G-CSF) secretion broadly attenuated the expression of EBIMφ marker genes. Notably, we identified the heme-induced transcription factor Spi-C as a robust marker of EBIMφs in Spicigfp/igfp mice. Two bone marrow cell populations, macrophages and Gr1-low monocytes, possessed cell-intrinsic Spic-GFP. Spic+ macrophages were distinguished by higher levels of green fluorescent protein, autofluorescence, F4/80, and CD163 while CD115 staining was negligible compared with Gr1-low monocytes. Application of Spicigfp/igfp mice in studies revealed a G-CSF–dependent reduction of Spic+ macrophages in postburn marrow, which coincided with a loss of erythroid cells and that G-CSF administration was sufficient to reduce Spic+ macrophages in the marrow. These results provide the first evidence that burn injuries impact the EBI niche through G-CSF–dependent reduction of Spic+ EBIMφs and support the use of Spicigfp/igfp mice in investigation of EBIMφs.
Role of 18F-fluorodeoxyglucose accumulation in radiological ground-glass opacity of non-small cell lung cancer
Authors: Otabe Masaya , Mimae Takahiro , Miyata Yoshihiro , Tsubokawa Norifumi , Kudo Yujin , Nagashima Takuya , Ito Hiroyuki , Ikeda Norihiko , Okada Morihito 
Published: February 2025

Abstract

Background
This study aimed to elucidate the significance of the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) by radiological ground glass opacity (GGO) tumors of non-small cell lung cancer (NSCLC), particularly in tumors assumed to be pathologically non-invasive.

Methods
Overall, 709 consecutive patients with GGO-dominant NSCLC who underwent complete resections at three institutions between 2017 and 2022 were included. GGO-dominant tumors and pure GGO tumors were evaluated based on the SUVmax. The adenocarcinoma subtypes were categorized into low, medium, and high grade. The correlation between the SUVmax, pathological malignant grade, and pathological invasive diameter was examined.

Results
In GGO-dominant lung adenocarcinoma, the SUVmax correlated positively with the pathological malignant grade and the pathological invasive diameters (respectively, (P = .0001), (P &lt; .0001)). Similarly, in pure GGO lung adenocarcinoma, the SUVmax correlated positively with the pathological malignant grade. The median pathological invasive diameter was higher in patients with SUVmax ≥ 1.0 compared to those with SUVmax &lt; 1.0 [10 mm vs 0 mm, respectively, (P = .017)].

Conclusions
A higher accumulation of FDG than in the background lung reflects invasive components even in pure GGO areas where only non-invasive components are expected. An FDG-PET/CT can complement the qualitative diagnosis in predicting invasive components with limitations in high-resolution computed tomography alone.
Validation of objective performance metrics via an intelligent medical network in gynecological oncology robotic surgery
Authors: Yanazume Shintaro , Kobayashi Yusuke , Furuzono Nozomi , Fukuda Mika , Togami Shinichi , Kobayashi Hiroaki 
Published: February 2025

Abstract

Background
Automated performance metrics (APMs) are potentially useful to accurately assess and improve surgeon skills and patient outcomes, while their clinical use is currently limited. We report on the use of the Medicaroid Intelligent Network System (MINS™), a network support system platform used together with the “hinotori” surgical robot system (hinotori™) for the collection of data logs from surgeries, and discuss its potential to improve surgical outcomes.

Methods
This study prospectively evaluated the efficacy of MINS™ for collecting data logs in gynecologic oncologic robotic surgery between December 2022 and February 2024 in nine patients. MINS™ regularly communicated with the hinotori™ via a secure network to collect and send system logs to a cloud server, quantifying various performance data for the evaluation of surgical outcomes.

Results
Clinical data on hinotori™ movement were successfully extracted. The number of operation arm (OA) changes was significantly higher in Patient No. 7, who underwent pelvic lymph node dissection. OA3 monopolar was used more frequently than OA1 bipolar for coagulation (mean: 6.7% vs 2.5%, P ˂0.001). The error count and percentage of inactive time associated with OA collisions decreased dramatically after Patient No. 6, following the version upgrade in July 2024.

Conclusion
MINS™ utilizes technology to connect the hinotori™ to various systems via the Internet, allowing objective evaluations of surgical procedures from data logs. MINS™ is a clinically applicable APM system that objectively analyzes a surgeon's individuality and has the potential to improve surgical techniques and promote standardization.
ENO1–BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism
Authors: Li Zhikun , Fan Kaixiang , Suo Caixia , Gu Xuemei , Zhu Chuxu , Wei Haoran , Chen Liang , Gao Ping , Sun Linchong 
Published: February 2025

Abstract
Enolase 1 (ENO1) is a glycolytic enzyme involved in tumour progression that performs a variety of classical and nonclassical functions. However, the mechanism by which it promotes tumour progression is still not fully understood. Here, we found that ENO1 can bind to β-site amyloid precursor protein cleaving enzyme 2 (BACE2), a codependent gene of ENO1, in liver cancer cells. By suppressing lysosomal-dependent degradation, ENO1 stabilises BACE2 protein level without affecting its mRNA level. Further analysis revealed that ENO1 and BACE2 promote low-density lipoprotein receptor (LDLR) cleavage, leading to decreased absorption of exogenous cholesterol. To maintain intracellular cholesterol levels, ENO1 and BACE2 upregulate the expression of genes involved in de novo cholesterol synthesis through a negative feedback mechanism. Both in vitro and in vivo, BACE2 mediates the tumour-promoting effect of ENO1 in liver cancer. Finally, high expression levels of ENO1 and BACE2 and low expression levels of LDLR were detected in clinical HCC samples, and abnormal expression of the ENO1–BACE2–LDLR axis was significantly associated with poor prognosis in patients with liver cancer. These data collectively demonstrated that ENO1 functions in protein cleavage by binding to BACE2 and promotes liver cancer progression by reprogramming cholesterol metabolism.
Health effects of indium compounds in animal experiments
Authors: Tanaka Akiyo 
Published: February 2025

Abstract
Before 2000, very little attention had been paid to the health effects of indium, a rare metal, because there was very little information in the literature on its toxicity. A fatal case of indium-tin oxide (ITO) inhalation occurred in 2001, followed by concerns regarding occupational exposure to indium compounds and their health effects. Epidemiological studies and case reports have established a causal relationship between the inhalation of insoluble indium compounds, mainly ITO and the development of lung damage. This review has focused on the results of animal studies of ITO and other insoluble indium compounds. Available data indicate that insoluble indium compounds such as ITO, indium arsenide (InAs), indium phosphide (InP), copper indium gallium, and diselenium (CIGS) solar cell materials are toxic to the lungs of animals. In addition to lung damage, ITO nanoparticles have been found to cause kidney damage, while InAs, InP, and ITO cause testicular damage. Furthermore, InP has demonstrated compelling evidence of its carcinogenic potential in long-term inhalation studies using rats and mice, which was evident in rats exposed to ITO. Based on the results of these animal experiments, the International Agency for Research on Cancer evaluated InP as probably carcinogenic to humans (Group 2A) and ITO as possibly carcinogenic to humans (Group 2 B). Hence, occupational exposure of humans to insoluble indium compounds not only causes lung damage, but also lung carcinogenesis and kidney or testicular damage. Greater attention should be directed towards human occupational exposure to insoluble indium compounds.
Interosseous impasse: a unique case of bullet lodgement between the radius and ulna
Authors: Omari Rand Y , Mohammedali Shiyas , Quazi Sohail J , El-Debs Mohammed , Al-Omari Ahmad Y , Mohammed Mazin , Muneer Mohammed 
Published: February 2025

Abstract
Gunshot injuries to the upper limb are complex, particularly when a projectile lodges between the radius and ulna. These cases demand a detailed approach due to the complicated anatomy and potential for severe functional impairment. A 42-year-old female presented with severe right upper limb pain and motor impairment following a gunshot injury. The bullet entered through the posterior shoulder, shattered the mid-humerus and proximal radius, and lodged between the distal radius and ulna. Multidisciplinary surgical intervention included external fixator application and removal, open reduction, and internal fixation of the humerus, complete nerve decompression, and vascular repair using an interposition reversed saphenous vein graft. The patient’s postoperative course was uneventful, and follow-up showed sensory improvement and some motor recovery. This case highlights the complexity of managing gunshot injuries with bullets lodged between the radius and ulna. Multidisciplinary care is essential for addressing the varied challenges posed by such injuries. Further research is needed to refine treatment strategies and improve patient outcomes in similar cases.
Spontaneous brachiocephalic artery dissection: a case report
Authors: Murray Lewis William 
Published: February 2025

Abstract
Spontaneous dissection of the brachiocephalic artery is incredibly rare event with only six reported cases in the medical literature. These dissections are associated with significant morbidity and mortality. Given the rarity, there is currently no clear consensus on the management and this present a significant challenge to clinicians. This case reports the successful management of a spontaneous brachiocephalic dissection in a 63-year-old male with pre-existing coronary disease.
Memoryscapes of Martyrdom: Nineteenth-Century Poetry and the Death of Emily Wilding Davison in the Suffragette (1913)
Authors: Van Remoortel Marianne 
Published: February 2025

ABSTRACT
This article examines the reuse of nineteenth-century poetry in the Suffragette (1912–15), the official paper of the Women’s Social and Political Union (WSPU) edited by Christabel Pankhurst, as part of the reportage on the death and funeral of suffragette Emily Wilding Davison (1872–1913). Davison was fatally injured when she stepped in front of the King’s horse during a protest at the Epsom Derby on 4 June 1913, and was hailed by the WSPU as a martyr to the cause of women’s suffrage. Previous scholarship has argued that Davison’s martyrdom was grounded in religion, with the WSPU portraying her as a female Christ or modern Joan of Arc. This article presents a more complex picture by drawing attention to the many instances of both secular and religious martyr poetry – often quoted from nineteenth-century poets – published in the Suffragette in the two weeks following Davison’s death. Considering the Suffragette’s coverage of the Derby event and its aftermath as activist memoryscape, it brings recent scholarship in memory studies into conversation with insights from the field of periodical studies. In doing so, the article aims to demonstrate that the image of Davison that the WSPU sought to project into the future was constructed from a wide range of martyr traditions and was particularly intertwined with the memories of martyrdom preserved in poetry by two major nineteenth-century social movements: socialism and abolitionism.
Gas accretion at high redshift: cold flows all the way
Authors: Waterval Stefan , Cannarozzo Carlo , Macciò Andrea V 
Published: February 2025

ABSTRACT
We study in detail how massive galaxies accrete gas through cosmic time using cosmological hydrodynamical simulations from the High-z Evolution of Large and Luminous Objects (HELLO) and the Numerical Investigation of a Hundred Astrophysical Objects (NIHAO) projects. We find that accretion through cold filaments at high z ($z\approx 2$–4) is a key factor in maintaining the high star-formation rates ($\gtrsim 100\, {\mathrm{M}}_{\odot }\, \mathrm{yr}^{-1}$) observed in these galaxies, and that more than 75 per cent of the total gas participating in the star formation process is accreted via this channel at high z even in haloes well above $10^{12}$ ${\mathrm{M}}_{\odot }$. The low volume occupancy of the filaments allows plenty of space for massive gas outflows generated by the vigorous star formation and AGN activity, with the cold incoming gas and the hot outflowing gas barely interacting. We present a model based on Bayesian hierarchical formalism able to accurately describe the evolution of the cold fraction accretion with redshift and halo mass. Our model predicts a relatively constant critical mass ($M_{\mathrm{c}}$) for cold-to-hot transition up to $z\sim 1.3$ and an evolving critical mass $\log (M_{\mathrm{c}}) \propto \log (1+z)^{1.7}$ at higher redshift. Overall, our findings provide deeper insight into the cosmic evolution of gas accretion modes and offer a robust framework for understanding how cold accretion contributes to galaxy growth across different epochs.
Survey of radiative, two-temperature magnetically arrested simulations of the black hole M87* I: turbulent electron heating
Authors: Chael Andrew 
Published: February 2025

ABSTRACT
We present a set of 11 two-temperature, radiative, general relativistic magnetohydrodynamic simulations of the black hole M87* in the magnetically arrested state, surveying different values of the black hole spin $a_*$. Our 3-D simulations self-consistently evolve the temperatures of separate electron and ion populations under the effects of adiabatic compression/expansion, viscous heating, Coulomb coupling, and synchrotron, bremsstrahlung, and inverse Compton radiation. We adopt a subgrid heating prescription from gyrokinetic simulations of plasma turbulence. Our simulations have accretion rates $\dot{M}=(0.5-1.5)\times 10^{-6}\dot{M}_{\rm Edd}$ and radiative efficiencies $\epsilon _{\rm rad}=$ 3–35 per cent. We compare our simulations to a fiducial set of otherwise identical single-fluid general relativistic magnetohydrodynamic (GRMHD) simulations and find no significant changes in the outflow efficiency or black hole spin-down parameter. Our simulations produce an effective adiabatic index for the two-temperature plasma of $\Gamma _{\rm gas}\approx 1.55$, larger than the $\Gamma _{\rm gas}=13/9$ value often adopted in single-fluid GRMHD simulations. We find moderate ion-to-electron temperature ratios in the 230 GHz emitting region of $R=T_{\rm i}/T_{\rm e}\,{\approx }\,5$. While total intensity 230 GHz images from our simulations are consistent with Event Horizon Telescope (EHT) results, our images have significantly more beam-scale linear polarization ($\langle |m|\rangle \approx 30~{{\rm per\ cent}}$) than is observed in EHT images of M87* ($\langle |m|\rangle \lt 10~{{\rm per\ cent}}$). We find a trend of the average linear polarization pitch angle $\angle \beta _2$ with black hole spin consistent with what is seen in single-fluid GRMHD simulations, and we provide a simple fitting function for $\angle \beta _2(a_*)$ motivated by the wind-up of magnetic field lines by black hole spin in the Blandford–Znajek mechanism.
V498 Hya, a new candidate for a period bouncer cataclysmic variable
Authors: Tovmassian Gagik , Inight Keith , Pala Anna Francesca , Gänsicke Boris T , Chandra Vedant , Green Matthew , Toloza Odette , Schreiber Matthias R 
Published: February 2025

ABSTRACT
V498 Hya (SDSS J084555.07+033929.2) was identified as a short-period cataclysmic variable (CV) by the Catalina Real-Time Transient Survey (CRTS) in 2008. The superhump period was measured during the detected single superoutburst of V498 Hya. The quiescent spectrum subsequently taken by the Sloan Digital Sky Survey-V Milky Way Mapper survey suggested that the CV donor may be a brown dwarf. We present time-resolved follow-up spectroscopy of V498 Hya in quiescence, obtained with the Gran Telescopio Canarias (GTC) Optical System for Imaging and low-intermediate-resolution Integrated Spectroscopy (OSIRIS) spectrograph, from which we derived the 86.053 min spectroscopic period, systemic radial velocity, and the gravitational redshift of the Mg ii line. We also modelled the spectral energy distribution to constrain the system parameters, including the ≥0.82 $\mathrm{ M}_\odot$ mass of the white dwarf and the best-fitting value $0.043\pm 0.004\ \mathrm{M}_\odot$ of the donor star mass. This combination of parameters implies that V498 Hya has evolved past the period minimum and is a relatively rare ‘period bouncer’.
Structure of gaps induced by retrograde satellites embedded in accretion discs
Authors: Sánchez-Salcedo F J , Santillán A 
Published: February 2025

ABSTRACT
Using 2D simulations, we investigate how a non-accreting satellite on a fixed retrograde circular orbit affects the structure of the accretion disc in which it is embedded. We vary the satellite-to-primary mass ratio q, the disc viscosity $\nu$, and the inner boundary conditions. A viscous criterion for gap opening is derived, which is broadly consistent with the simulations. We find a scaling relation of the gap depth with q and $\nu$. Unlike the prograde case, the satellite is located at the gap’s inner edge, resulting in a surface density at the satellite’s orbital radius up to 20 times higher than at the gap’s minimum. As the viscosity decreases, the gap depth increases, while the radial shift of the gap and the satellite’s orbital radius decreases. Gap-opening satellites may drive radial motions in the disc, producing eccentric gaps. Positioned at the gap edge, satellites experience a rapidly fluctuating environment. Migrating satellites can develop orbital eccentricities comparable to the disc’s aspect ratio. In a 3D simulation with $q=0.01$, the flow velocity exhibits a notorious vertical component in the gap’s inner edge. A comparison between 2D and 3D simulations reveals a slight radial offset in gap position, resulting in a lower surface density at the perturber’s orbital radius in the 3D simulation.
Large serine integrases utilise scavenged phage proteins as directionality cofactors
Authors: Alsaleh Abdulrazak , Holland Alexandria , Shin Heewhan , Reyes Tania Pena , Baksh Aron , Taiwo-Aiyerin Oluwateniola T , Pigli Ying , Rice Phoebe A , Olorunniji Femi J 
Published: February 2025

Abstract
Recombination directionality factors (RDFs) for large serine integrases (LSIs) are cofactor proteins that control the directionality of recombination to favour excision over insertion. Although RDFs are predicted to bind their cognate LSIs in similar ways, there is no overall common structural theme across LSI RDFs, leading to the suggestion that some of them may be moonlighting proteins with other primary functions. To test this hypothesis, we searched for characterized proteins with structures similar to the predicted structures of known RDFs. Our search shows that the RDFs for two LSIs, TG1 integrase and Bxb1 integrase, show high similarities to a single-stranded DNA binding (SSB) protein and an editing exonuclease, respectively. We present experimental data to show that Bxb1 RDF is probably an exonuclease and TG1 RDF is a functional SSB protein. We used mutational analysis to validate the integrase-RDF interface predicted by AlphaFold2 multimer for TG1 integrase and its RDF, and establish that control of recombination directionality is mediated via protein–protein interaction at the junction of recombinase’s second DNA binding domain and the base of the coiled-coil domain.
A gate-clamp mechanism for ssDNA translocation by DdmD in Vibrio cholerae plasmid defense
Authors: Li Ruoyu , Liu Yusong , Gao Haishan , Lin Zhonghui 
Published: February 2025

Abstract
The DdmDE antiplasmid system, consisting of the helicase-nuclease DdmD and the prokaryotic Argonaute (pAgo) protein DdmE, plays a crucial role in defending Vibrio cholerae against plasmids. Guided by DNA, DdmE specifically targets plasmids, disassembles the DdmD dimer, and forms a DdmD–DdmE handover complex to facilitate plasmid degradation. However, the precise ATP-dependent DNA translocation mechanism of DdmD has remained unclear. Here, we present cryo-EM structures of DdmD bound to single-stranded DNA (ssDNA) in nucleotide-free, ATPγS-bound, and ADP-bound states. These structures, combined with biochemical analysis, reveal a unique “gate-clamp” mechanism for ssDNA translocation by DdmD. Upon ATP binding, arginine finger residues R855 and R858 reorient to interact with the γ-phosphate, triggering HD2 domain movement. This shift repositions the gate residue Q781, causing a flip of the 3′ flank base, which is then clamped by residue F639. After ATP hydrolysis, the arginine finger releases the nucleotide, inducing HD2 to return to its open state. This conformational change enables DdmD to translocate along ssDNA by one nucleotide in the 5′ to 3′ direction. This study provides new insights into the ATP-dependent translocation of DdmD and contributes to understanding the mechanistic diversity within SF2 helicases.