bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic orchidopexy for the treatment of cryptorchidism in adults: a description of the technique and outcomes
Authors: Han Hu , Li Jiaxing , Lei Hong-en , Yin Hang , Tian Long 
Published: January 2024

Abstract
Background
There are few studies on cryptorchidism in adults, and its treatment is still controversial.

Methods
To summarize the surgical strategy and clinical efficacy of laparoscopic orchidopexy for the treatment of cryptorchidism in adults, 37 adult cryptorchidism patients were retrospectively analyzed between September 2017 and February 2022. All 37 patients underwent laparoscopic orchidopexy, of whom 33 underwent inguinal hernia repair without tension. The intraoperative procedures and surgical techniques were recorded in detail. Preoperative examination and regular postoperative review of color Doppler ultrasound, and reproductive hormone, alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase levels were performed.

Results
All testes descended successfully into the scrotum, including 25 through the inguinal route and 12 through Hesselbach’s triangle route. No intraoperative or postoperative complications were observed. The follow-up time was 38.6 (± 19.4) months, and no evidence of testicular malignancy was found during the follow-up period. After analyzing the reproductive hormone levels at 1 year postoperatively in 28 patients with more than 1 year of follow-up, it was found that the patients had a significant increase in testosterone levels and a decrease in follicle-stimulating hormone levels after surgery. None of the patients showed any significant improvement in semen quality after surgery.

Conclusion
Our study suggests that laparoscopic orchidopexy is a safe and feasible surgical procedure for the treatment of cryptorchidism in adults, especially high cryptorchidism, which is difficult to treat. After comprehensive consideration, preserving the testis should be preferred for treating cryptorchidism in adults to maximize the protection of the patient’s reproductive hormone secretion function.
Structure based docking and biological evaluation towards exploring potential anti-cancerous and apoptotic activity of 6-Gingerol against human prostate carcinoma cells
Authors: Khan Habiba , Azad Iqbal , Arif Zeeshan , Parveen Shama , Kumar Saurabh , Rais Juhi , Ansari Jamal Akhtar , Nasibullah Malik , Kumar Sudhir , Arshad Md 
Published: January 2024

Abstract
Background
6-Gingerol (6-G) is the primary active phytocomponent of ginger and has been shown to regulate multiple targets against cancer and its treatment. Androgen receptors (ARs) remain critical in the progression of prostate cancer (PCa). This study focuses on investigating 6-G as a promising anti-cancerous agent that inhibits AR activity significantly.

Methods
In this study, molecular docking simulation was done to investigate the binding affinity of 6-G and control drug Bicalutamide (BT) against oncogenic AR and tumor suppressor estrogen receptor β (ERβ). The crystal structure of AR and ERβ was retrieved from Protein Data Bank (PDB) and docked with 3D Pubchem structures of 6-G using iGEMDOCK and AutoDock. Further in vitro study was done to evaluate the antioxidant, anti-cancerous, apoptotic, and wound healing potential of 6-G.

Results
The result displays that 6-G shows good binding affinity with AR and ERβ. Condensation of the nucleus, change in mitochondrial membrane potential (MMP) and the ability to induce reactive oxygen species (ROS) were done in human PCa PC-3 cells. Results from the MTT assay demonstrated that 6-G and control drug BT showed significant (p < 0.01) dose and time dependent inhibition of human PCa PC-3 cells. 6-G increased the ROS generation intracellularly and decreased the MMP, and cell migration in treated PCa PC-3 cells. 6-G treated cells showed fragmented, condensed chromatin and nuclear apoptotic bodies.

Conclusions
Thus, this study validates 6-G as a potential drug candidate against human PCa. However, further study of the anticancer potency of 6-G has to be done before its use for PCa treatment.
Exploring the care experiences of hemodialysis nurses: from the cultural sensitivity approach
Authors: Jui-Chin Hsu , Fen-Fang Chung , Tso-Ying Lee , Pao-Yu Wang , Mei-Hsiang Lin 
Published: January 2024

Abstract
Background
Culturally sensitive care has been identified as a best-practice approach for improving health outcomes. Hemodialysis patients require culturally sensitive care because it involves totally changing their previous life. The purpose of this study was to explore the subjective experiences of hemodialysis nurses in providing culturally sensitive care to hemodialysis patients.

Methods
A qualitative study was carried out in the hemodialysis center of a teaching hospital in northern Taiwan. Purposive sampling and semi-structured interview guidelines were employed to interview 23 hemodialysis nurses. The interviews were recorded and transcribed verbatim, and the resulting data were analyzed and summarized using content analysis by constant comparative methods.

Results
Hemodialysis nurses exhibited the characteristics for delivering culturally sensitive care, which comprised five aspects: finding the true meaning of the behavior of the participants, recognizing and honoring individual psychological states, culturally sensitive communication in line with patients’ values, customizing care content through cultural transformation strategies, and empowerment rather than prohibition.

Conclusions
The findings of this study on the culturally sensitive care provided by hemodialysis nurses can be utilized by nursing educators and administrators as a reference to develop and enhance the nursing education related to culturally sensitive care for hemodialysis professionals.
The role of psychosocial well-being and emotion-driven impulsiveness in food choices of European adolescents
Authors: Do Stefanie , Didelez Vanessa , Börnhorst Claudia , Coumans Juul M.J. , Reisch Lucia A. , Danner Unna N. , Russo Paola , Veidebaum Toomas , Tornaritis Michael , Molnár Dénes , Hunsberger Monica , De Henauw Stefaan , Moreno Luis A. , Ahrens Wolfgang , Hebestreit Antje ,   on behalf of the IDEFICS/I.Family consortia
Published: January 2024

Abstract
Background
It is unclear whether a hypothetical intervention targeting either psychosocial well-being or emotion-driven impulsiveness is more effective in reducing unhealthy food choices. Therefore, we aimed to compare the (separate) causal effects of psychosocial well-being and emotion-driven impulsiveness on European adolescents’ sweet and fat propensity.

Methods
We included 2,065 participants of the IDEFICS/I.Family cohort (mean age: 13.4) providing self-reported data on sweet propensity (score range: 0 to 68.4), fat propensity (range: 0 to 72.6), emotion-driven impulsiveness using the UPPS-P negative urgency subscale, and psychosocial well-being using the KINDLR Questionnaire. We estimated, separately, the average causal effects of psychosocial well-being and emotion-driven impulsiveness on sweet and fat propensity applying a semi-parametric doubly robust method (targeted maximum likelihood estimation). Further, we investigated a potential indirect effect of psychosocial well-being on sweet and fat propensity mediated via emotion-driven impulsiveness using a causal mediation analysis.

Results
If all adolescents, hypothetically, had high levels of psychosocial well-being, compared to low levels, we estimated a decrease in average sweet propensity by 1.43 [95%-confidence interval: 0.25 to 2.61]. A smaller effect was estimated for fat propensity. Similarly, if all adolescents had high levels of emotion-driven impulsiveness, compared to low levels, average sweet propensity would be decreased by 2.07 [0.87 to 3.26] and average fat propensity by 1.85 [0.81 to 2.88]. The indirect effect of psychosocial well-being via emotion-driven impulsiveness was 0.61 [0.24 to 1.09] for average sweet propensity and 0.55 [0.13 to 0.86] for average fat propensity.

Conclusions
An intervention targeting emotion-driven impulsiveness, compared to psychosocial well-being, would be marginally more effective in reducing sweet and fat propensity in adolescents.
Towards a standardized program of transitional care for adolescents with juvenile idiopathic arthritis for Turkey: a national survey study
Authors: Sözeri Betül , Şahin Nihal , Açarı Ceyhun , Avar Aydın Pinar Ozge , Baba Ozge , Bağlan Esra , Bakkaloğlu Sevcan , Bakırcı Sibel , Bilginer Yelda , Bozkaya Burcu Yücel , Çağlayan Şengül , Çakan Mustafa , Çakmak Figen , Coşkuner Taner , Demir Ferhat , Demirkan Fatma Gül , Doğantan Şeyda , Adıgüzel Dündar Hatice , Ersözlü Emine Duygu , Gücenmez Sercan , Gürler Oğuz , İşgüder Rana , Küçük Adem , Kalyoncu Mukaddes , Kılıç Levent , Kılıç Sara Şebnem , Kısaoğlu Hakan , Paç Kısaarslan Ayşenur , Kızıldağ Zehra , Kurtuluş Duygu , Özdel Semanur , Öztürk Kübra , Şenol Pelin , Tanatar Ayşe , Taşkın Sema Nur , Tuncer Kuru Fatma , Türkuçar Serkan , Ulu Kadir , Ünsal Erbil , Yazıcı Ayten , Gezgin Yıldırım Deniz , Yüksel Selçuk , Kasapçopur Özgür , Özen Seza , Aktay Ayaz Nuray , Sönmez Hafize Emine 
Published: January 2024

Abstract
Background
Juvenile idiopathic arthritis (JIA) is a prevalent childhood chronic arthritis, often persisting into adulthood. Effective transitional care becomes crucial as these patients transition from pediatric to adult healthcare systems. Despite the concept of transitional care being recognized, its real-world implementation remains inadequately explored. This study aims to evaluate the thoughts and practices of healthcare providers regarding transitional care for JIA patients.

Methods
A cross-sectional survey was conducted among pediatric and adult rheumatologists in Turkey. Based on the American Academy of Pediatrics’ six core elements of transitional care, the survey included 86 questions. The respondents’ demographic data, attitudes towards transitional care, and practical implementation were assessed.

Results
The survey included 48 rheumatologists, with 43.7% having a transition clinic. The main barriers to establishing transition programs were the absence of adult rheumatologists, lack of time, and financial constraints. Only 23.8% had a multidisciplinary team for transition care. Participants agreed on the importance of coordination and cooperation between pediatric and adult healthcare services. The timing of the transition process varied, with no consensus on when to initiate or complete it. Participants advocated for validated questionnaires adapted to local conditions to assess transition readiness.

Conclusions
The study sheds light on the challenges and perspectives surrounding transitional care for JIA patients in Turkey. Despite recognized needs and intentions, practical implementation remains limited due to various barriers. Cultural factors and resource constraints affect the transition process. While acknowledging the existing shortcomings, the research serves as a ground for further efforts to improve transitional care and ensure better outcomes for JIA patients transitioning into adulthood.
An aging-related immune landscape in the hematopoietic immune system
Authors: Lv Jianjie , Zhang Chun , Liu Xiuxing , Gu Chenyang , Liu Yidan , Gao Yuehan , Huang Zhaohao , Jiang Qi , Chen Binyao , He Daquan , Wang Tianfu , Xu Zhuping , Su Wenru 
Published: January 2024

Abstract
Background
Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, while the spleen, as the most important extramedullary hematopoietic immune organ, maintains homeostasis of the human hematopoietic immune system (HIS) in cooperation with the bone marrow. However, the overall changes in the HIS during aging have not been described. Here, we describe a hematopoietic immune map of the spleen and bone marrow of young and old mice using single-cell sequencing and flow cytometry techniques.

Results
We observed extensive, complex changes in the HIS during aging. Compared with young mice, the immune cells of aged mice showed a marked tendency toward myeloid differentiation, with the neutrophil population accounting for a significant proportion of this response. In this change, hypoxia-inducible factor 1-alpha (Hif1α) was significantly overexpressed, and this enhanced the immune efficacy and inflammatory response of neutrophils. Our research revealed that during the aging process, hematopoietic stem cells undergo significant changes in function and composition, and their polymorphism and differentiation abilities are downregulated. Moreover, we found that the highly responsive CD62L + HSCs were obviously downregulated in aging, suggesting that they may play an important role in the aging process.

Conclusions
Overall, aging extensively alters the cellular composition and function of the HIS. These findings could potentially give high-dimensional insights and enable more accurate functional and developmental analyses as well as immune monitoring in HIS aging.
Inequalities in unmet health care needs under universal health insurance coverage in China
Authors: Wu Jingxian , Yang Yongmei , Sun Ting , He Sucen 
Published: January 2024

Abstract
Background
Expanding health insurance is a critical step towards universal health coverage due to its positive effect on reducing unmet health care needs and enhancing equitable access to health care. Despite previous studies on the socioeconomic factors associated with unmet health care needs, few studies have analysed the inequalities in such needs and the impact of universal health insurance coverage on addressing them. This study aimed to measure the contribution of social health insurance (SHI) coverage to inequalities in financially and non-financially constrained unmet health care needs among middle-aged and elderly Chinese adults.

Methods
The study data were obtained from the China Health and Retirement Longitudinal Study (2011–2015). A total of 11,592 respondents reporting outpatient care needs and 6320 reporting inpatient care needs were included. The concentration index (CI) was employed to measure the extent of income-related inequalities in unmet health care needs. A decomposition method based on a probit model was used to investigate the contribution of SHI to the inequalities.

Results
The incidence rates of unmet outpatient needs due to financial and non-financial constraints were 4.68% and 24.78%, respectively; these rates were 18.69% and 15.73% for unmet inpatient needs. The CIs of unmet outpatient needs due to financial and non-financial constraints were − 0.1872 and 0.0195, respectively; these values were − 0.1558 and 0.0352 for unmet inpatient needs. The percentages of the contribution of SHI to the CIs of financially constrained unmet outpatient and inpatient needs were 0.2639% and 1.8898%, respectively. Moreover, the percentages of the contribution of SHI to the CIs of non-financially constrained unmet outpatient and inpatient needs were − 0.4513% and − 6.4192%, respectively.

Conclusion
The universal coverage of SHI in China increased pro-poor inequalities in financially constrained unmet health care needs but decreased pro-rich inequalities in non-financially constrained unmet needs. Additionally, the contribution of SHI to inequalities in financially constrained unmet needs for inpatient care was stronger than that for outpatient care. Policy-makers are advised to introduce favourable reimbursement policies for patients with poor socioeconomic conditions and address both financial and non-financial barriers to promote equitable access to health care for the entire population.
Weight stigma in healthcare settings: the experience of Arab and Jewish bariatric surgery candidates in Israel
Authors: Zahra-Zeitoun Yara , Elran-Barak Roni , Salameh-Dakwar Rawan , Froylich Dvir , Sroka Gideon , Assalia Ahmed , Latzer Yael 
Published: January 2024

Abstract
Background
Weight-related stigma and discrimination are prevalent in our society with adverse biopsychosocial outcomes to people with obesity and morbid obesity. Studies suggest that weight bias in healthcare settings are quite prevalent, but there have been, as far as we know, lack of studies examining prevalence and correlates of weight bias experiences among bariatric surgery candidates in Israel. We aim to understand the nature and prevalence of weight stigma among bariatric surgery candidates. To identify differences between Jewish and Arab candidates. To examine the impact of weight stigma experiences on weight bias internalization (WBI).

Methods
A cross-sectional study was performed among 117 adult bariatric surgery candidates from three hospitals in northern Israel (47.8% Jews, 82.4% females, average BMI 42.4 ± 5.2 Kg/meter2). Patients who agreed to participate completed a structured questionnaire on the same day that the bariatric surgery committee met. WBI was measured using a validated 10-item scale. Experiences of weight stigma were measured using items adapted from prior international studies.

Results
About two thirds of the participants had at least one experience of weight stigma (teased, treated unfairly, or discriminated against because of their weight). As many as 75% of participants reported that weight served as a barrier to getting appropriate health care and as many as half of participants felt in the last year that a doctor judged them because of their weight. No significant differences were found between Arabs and Jews in the prevalence of weight stigma experiences and WBI. However, a trend towards more stigma experiences among Jews was noted. WBI was predicted by female gender and experiences of weight stigma, both in general and within healthcare settings.

Conclusions
Weight stigma towards bariatric surgery candidates in Israel is quite prevalent, and specifically in healthcare settings. It is important to adopt policy actions and intervention programs to improve awareness to this phenomenon among the general public and specifically among healthcare providers, as many healthcare providers may be unaware of the adverse effect of weight stigma and of ways in which they are contributing to the problem. Future studies may validate our findings using larger sample size and longitudinal design.
Strategies for enhancing the representation of women in clinical trials: an evidence map
Authors: Goldstein Karen M. , Kung Lindsay Chi Yan , Dailey Susan Alton , Kroll-Desrosiers Aimee , Burke Colleen , Shepherd-Banigan Megan , Lumsden Rebecca , Sims Catherine , Schexnayder Julie , Patel Dhara , Cantrell Sarah , Sheahan Kate L. , Gierisch Jennifer M. 
Published: January 2024

Abstract
Background
Equitable sex- and gender-based representation in clinical trials is an essential step to ensuring evidence-based care for women. While multi-institutional actions have led to significant improvements in the inclusion of women in trials, inequity persists in areas like sex-neutral cancers and cardiovascular disease. We sought to identify strategies described or evaluated to boost the inclusion of women in clinical trials.

Methods
We used evidence mapping methodology to examine the breadth of relevant literature. We developed an a priori protocol and followed reporting guidance from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis where applicable. We searched MEDLINE® (via PubMed) and EMBASE (via Elsevier) databases from inception through April 4, 2023, and used standardized procedures incorporating duplication and data verification. We included articles that described strategies to improve the recruitment and retention of women in clinical trials.

Results
We identified 122 articles describing recruitment and retention strategies for 136 trials (377,595 women). Only one article distinguished between the sex and gender identity of participants, and none defined their use of the terms such as “women” or “female”. The majority of articles (95%) described recruitment for only women, and 64% were conducted in the USA. Ninety-two articles (75%) described strategies in the context of sex-specific conditions (e.g., gynecologic diagnosis). The majority of included articles evaluated a behavioral intervention (52%), with 23% evaluating pharmacologic interventions and 4% invasive interventions. The most common trial phase for reported strategies was during outreach to potential participants (116 articles), followed by intervention delivery (76), enrollment (40), outcomes assessment (21), analysis and interpretation (3), and dissemination (4). We describe specific types of strategies within each of these phases.

Conclusions
Most of the existing literature describing strategies to improve the inclusion of women draws from trials for sex-specific conditions and is largely related to outreach to potential participants. There is little information about how and if studies have attempted to proportionally increase the inclusion of women in trials with both men and women or those focused on invasive and pharmacologic interventions. Future work in this area should focus on how to increase the participation of women in mixed-sex studies and on those areas with remaining inequities in trial participation.
Time series forecasting model for non-stationary series pattern extraction using deep learning and GARCH modeling
Authors: Han Huimin , Liu Zehua , Barrios Barrios Mauricio , Li Jiuhao , Zeng Zhixiong , Sarhan Nadia , Awwad Emad Mahrous 
Published: January 2024

AbstractThis paper presents a novel approach to time series forecasting, an area of significant importance across diverse fields such as finance, meteorology, and industrial production. Time series data, characterized by its complexity involving trends, cyclicality, and random fluctuations, necessitates sophisticated methods for accurate forecasting. Traditional forecasting methods, while valuable, often struggle with the non-linear and non-stationary nature of time series data. To address this challenge, we propose an innovative model that combines signal decomposition and deep learning techniques. Our model employs Generalized Autoregressive Conditional Heteroskedasticity (GARCH) for learning the volatility in time series changes, followed by Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) for data decomposition, significantly simplifying data complexity. We then apply Graph Convolutional Networks (GCN) to effectively learn the features of the decomposed data. The integration of these advanced techniques enables our model to fully capture and analyze the intricate features of time series data at various interval lengths. We have evaluated our model on multiple typical time-series datasets, demonstrating its enhanced predictive accuracy and stability compared to traditional methods. This research not only contributes to the field of time series forecasting but also opens avenues for the application of hybrid models in big data analysis, particularly in understanding and predicting the evolution of complex systems.