bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of effectiveness and safety of the CorPath GRX robotic system in endovascular embolization procedures of cerebral aneurysms
Authors: Mendes Pereira Vitor , Rice Hal , De Villiers Laetitia , Sourour Nader , Clarencon Frédéric , Spears Julian , Tomasello Alejandro , Hernandez David , Cancelliere Nicole M , Liu Xiao Yu Eileen , Nicholson Patrick , Costalat Vincent , Gascou Gregory , Mordasini Pasquale , Gralla Jan , Martínez-Galdámez Mario , Galvan Fernandez Jorge , Killer-Oberpfalzer Monika , Liebeskind David S , Turner Raymond D , Blanc Raphael , Piotin Michel 
Published: October 2023

BackgroundRobotic-assisted neurointervention was recently introduced, with implications that it could be used to treat neurovascular diseases.ObjectiveTo evaluate the effectiveness and safety of the robotic-assisted platform CorPath GRX for treating cerebral aneurysms.MethodsThis prospective, international, multicenter study enrolled patients with brain aneurysms that required endovascular coiling and/or stent-assisted coiling. The primary effectiveness endpoint was defined as successful completion of the robotic-assisted endovascular procedure without any unplanned conversion to manual treatment with guidewire or microcatheter navigation, embolization coil(s) or intracranial stent(s) deployment, or an inability to navigate vessel anatomy. The primary safety endpoint included intraprocedural and periprocedural events.ResultsThe study enrolled 117 patients (74.4% female) with mean age of 56.6 years from 10 international sites,. Headache was the most common presenting symptom in 40/117 (34.2%) subjects. Internal carotid artery was the most common location (34/122, 27.9%), and the mean aneurysm height and neck width were 5.7±2.6 mm and 3.5±1.4 mm, respectively. The overall procedure time was 117.3±47.3 min with 59.4±32.6 min robotic procedure time. Primary effectiveness was achieved in 110/117 (94%) subjects with seven subjects requiring conversion to manual for procedure completion. Only four primary safety events were recorded with two intraprocedural aneurysm ruptures and two strokes. A Raymond-Roy Classification Scale score of 1 was achieved in 71/110 (64.5%) subjects, and all subjects were discharged with a modified Rankin Scale score of ≤2.ConclusionsThis first-of-its-kind robotic-assisted neurovascular trial demonstrates the effectiveness and safety of the CorPath GRX System for endovascular embolization of cerebral aneurysm procedures.Trial registration numberNCT04236856
The Potwar Siwaliks: an impressive Neogene record of terrestrial rocks and fossils
Authors: Flynn Lawrence J. , Raza S. Mahmood , Morgan Michèle E. , Barry John C. , Pilbeam David 
Published: October 2023

Abstract
Outcropping sedimentary deposits of the Potwar Plateau in northern Pakistan comprise the most complete record of Neogene Siwalik rocks and faunas to be found in the Indian subcontinent documenting an extraordinary record of terrestrial vertebrate fossils for the Miocene Epoch. The Potwar Plateau is a portion of the Siwalik Hills, the mountainous terrane of the outer Himalayas extending over 2000 km across the northern margin of the Indian subcontinent. Siwalik strata accumulated as a molassic sedimentary wedge shed southward with the erosion of the rising crust as it was uplifted via plate tectonics. The long Potwar record of numerous superposed assemblages of fossil vertebrates preserves a history spanning many millions of years, and constitutes a unique geoheritage resource for Asia and for the world. The record can be dated and interpreted with a high degree of precision rarely achieved in terrestrial settings. The Potwar Siwalik sediments document 18 million years of change in the subtropical ecosystem of South Asia, in which global to regional climate change directly impacted terrestrial palaeofloras and palaeofaunas, forcing coevolution of elements of the terrestrial food web, and with that the modernization of mammalian groups. The potential to trace coincidence of abiotic changes with evolution within lineages is unusual.
Enabling Binary Neural Network Training on the Edge
Authors: Wang Erwei , Davis James J. , Moro Daniele , Zielinski Piotr , Lim Jia Jie , Coelho Claudionor , Chatterjee Satrajit , Cheung Peter Y. K. , Constantinides George A. 
Published: October 2023

The ever-growing computational demands of increasingly complex machine learning models frequently necessitate the use of powerful cloud-based infrastructure for their training. Binary neural networks are known to be promising candidates for on-device inference due to their extreme compute and memory savings over higher-precision alternatives. However, their existing training methods require the concurrent storage of high-precision activations for all layers, generally making learning on memory-constrained devices infeasible. In this article, we demonstrate that the backward propagation operations needed for binary neural network training are strongly robust to quantization, thereby making on-the-edge learning with modern models a practical proposition. We introduce a low-cost binary neural network training strategy exhibiting sizable memory footprint reductions while inducing little to no accuracy loss
vs
Courbariaux & Bengio’s standard approach. These decreases are primarily enabled through the retention of activations exclusively in binary format. Against the latter algorithm, our drop-in replacement sees memory requirement reductions of 3–5×, while reaching similar test accuracy (± 2 pp) in comparable time, across a range of small-scale models trained to classify popular datasets. We also demonstrate from-scratch ImageNet training of binarized ResNet-18, achieving a 3.78× memory reduction. Our work is open-source, and includes the Raspberry Pi-targeted prototype we used to verify our modeled memory decreases and capture the associated energy drops. Such savings will allow for unnecessary cloud offloading to be avoided, reducing latency, increasing energy efficiency, and safeguarding end-user privacy.
Community Outreach and Engagement at U.S. Cancer Centers: Notes from the Third Cancer Center Community Impact Forum
Authors: Leader Amy E. , Brandt Heather M. , Briant Katherine J. , Curry Gina , Ellis Kiara , Gonzalez Evelyn T. , Guerra Carmen E. , Harding Garrett , Hull Pamela C. , Israel Aimee , Mellilo Rebecca , Mesia Rachel J. , Schiffelbein Jenna E. , Song Yawei , Surani Zul , Tiro Jasmin A. , Vadaparampil Susan T. , Vanderpool Robin C. , Paskett Electra D. 
Published: October 2023

Abstract
Community outreach and engagement (COE) is a fundamental activity of cancer centers as they aim to reduce cancer disparities in their geographic catchment areas. As part of COE, NCI-Designated Cancer Centers must monitor the burden of cancer in their catchment area, implement and evaluate evidence-based strategies, stimulate catchment area relevant research, support clinical trial enrollment, and participate in policy and advocacy initiatives, in addition to other responsibilities. The Cancer Center Community Impact Forum (CCCIF) is a national annual meeting of COE professionals who work at or with cancer centers across the country. CCCIF grew out of earlier discussions at American Society of Preventive Oncology (ASPO) annual meetings, where COE was often discussed, but not exclusively. The third annual CCCIF meeting—hosted by the Sidney Kimmel Cancer Center at Thomas Jefferson University—was held in June 2022 in Philadelphia, PA, where more than 200 participants listened to dynamic presentations across 12 COE-related panel sessions. CCCIF leadership and ASPO AD/PL Workshop Planners worked together on the agenda. The 12 sessions used a COE lens to focus on: Diversity, Equity, and Inclusion; Policy; State Cancer Coalitions; Evaluation and Metrics; Implementation Science; In-reach; Outreach; Training and Education; Funding, Personnel and Resources; Clinical Trials; Innovative Methods; and Lessons from the COVID-19 pandemic. This article is a summary of main points and key lessons from each session, as well as a summary of overarching themes that were evident across the sessions.
Tumor-Agnostic Approvals: Insights and Practical Considerations
Authors: Lu Chengxing Cindy , Beckman Robert A. , Li Xiaoyun Nicole , Zhang Weidong , Jiang Qi , Marchenko Olga , Sun Zhiping , Tian Hong , Ye Jingjing , Yuan Shuai Sammy , Yung Godwin ,   on behalf of the Master Protocol subteam of the Statistical Methods in Oncology Scientific Working Group, Biopharmaceutical Session, American Statistical Association
Published: October 2023

Abstract
Since the first approval of a tumor-agnostic indication in 2017, a total of seven tumor-agnostic indications involving six drugs have received approval from the FDA. In this paper, the master protocol subteam of the Statistical Methods in Oncology Scientific Working Group, Biopharmaceutical Session, American Statistical Association, provides a comprehensive summary of these seven tumor-agnostic approvals, describing their mechanisms of action; biomarker prevalence; study design; companion diagnostics; regulatory aspects, including comparisons of global regulatory requirements; and health technology assessment approval. Also discussed are practical considerations relating to the regulatory approval of tumor-agnostic indications, specifically (i) recommendations for the design stage to mitigate the risk that exceptions may occur if a treatment is initially hypothesized to be effective for all tumor types and (ii) because drug development continues after approval of a tumor-agnostic indication, recommendations for further development of tumor-specific indications in first-line patients in the setting of a randomized confirmatory basket trial, acknowledging the challenges in this area. These recommendations and practical considerations may provide insights for the future development of drugs for tumor-agnostic indications.
Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial
Authors: Kawai Akira , Ishihara Mikiya , Nakamura Tomoki , Kitano Shigehisa , Iwata Shintaro , Takada Kohichi , Emori Makoto , Kato Koji , Endo Makoto , Matsumoto Yoshihiro , Kakunaga Shigeki , Sato Eiichi , Miyahara Yoshihiro , Morino Kunihiko , Tanaka Shinya , Takahashi Shuichi , Matsuo Fujio , Matsumine Akihiko , Kageyama Shinichi , Ueda Takafumi 
Published: October 2023

Abstract

Purpose:
To determine, for patients with advanced or recurrent synovial sarcoma (SS) not suitable for surgical resection and resistant to anthracycline, the safety and efficacy of the infusion of autologous T lymphocytes expressing NY-ESO-1 antigen-specific T-cell receptor (TCR) gene and siRNA to inhibit the expression of endogenous TCR (product code: TBI-1301).

Patients and Methods:
Eligible Japanese patients (HLA-A*02:01 or *02:06, NY-ESO-1-positive tumor expression) received cyclophosphamide 750 mg/m2 on days −3 and −2 (induction period) followed by a single dose of 5×109 (±30%) TBI-1301 cells as a divided infusion on days 0 and 1 (treatment period). Primary endpoints were safety-related (phase I) and efficacy-related [objective response rate (ORR) by RECIST v1.1/immune-related RECIST (irRECIST); phase II]. Safety- and efficacy-related secondary endpoints were considered in both phase I/II parts.

Results:
For the full analysis set (N = 8; phase I, n = 3; phase II, n = 5), the ORR was 50.0% (95% confidence interval, 15.7–84.3) with best overall partial response in four of eight patients according to RECIST v1.1/irRECIST. All patients experienced adverse events and seven of eight patients (87.5%) had adverse drug reactions, but no deaths were attributed to adverse events. Cytokine release syndrome occurred in four of eight patients (50.0%), but all cases recovered with prespecified treatment. Immune effector cell-associated neurotoxicity syndrome, replication-competent retrovirus, and lymphocyte clonality were absent.

Conclusions:
Adoptive immunotherapy with TBI-1301 to selectively target NY-ESO-1-positive tumor cells appears to be a promising strategy for the treatment of advanced or recurrent SS with acceptable toxicity.
Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer
Authors: Eisenmann Eric D. , Sparreboom Alex 
Published: October 2023

SummaryA recent article characterized dosing recommendations for cabozantinib in people living with HIV (PLWH) and cancer, a group that is often excluded from clinical trials. This study suggests cabozantinib is effective in cancers disproportionately impacting PLWH and has translational implications for the design of studies evaluating drug-drug interactions.See related article by Haigentz et al., p. 5038
Traditional and Novel Methods of Rainfall Observation and Measurement: A Review
Authors: Wang Xing , Shi Shuaiyi , Zhu Litao , Nie Yunfeng , Lai Guojun 
Published: October 2023

Abstract
Because of its high spatial and temporal variability, rainfall remains one of the most challenging meteorological variables to measure accurately. Obtaining high-quality rainfall products is essential for flood monitoring, disaster warning, and weather forecasting systems, but this is not always possible on the basis of current rainfall observation networks. Innovative alternatives draw inspiration from “citizen science” and “crowdsourcing,” allowing for opportunistic sensing of rainfall from existing measurements at a low cost, which has become a popular topic and is beginning to play an important role in developing rainfall observation systems. This paper reviews the current state of new rainfall observation approaches and explores their opportunities to complement more traditional ways of rainfall data collection in a hydrological context. Furthermore, the challenges of each new approach are discussed. Although these new options show great potential in enhancing the current rainfall network, they still face problems in terms of their accuracy, real-time accessibility, and limited applicability when individually employed. In contrast, the fusion of new measurements with traditional observation networks is feasible and will be effective for regional rainfall monitoring. This study also serves as an important reference in developing monitoring techniques for other environmental factors.

Significance Statement
New rainfall observation techniques provide a meaningful supplement to current rainfall networks in terms of spatiotemporal resolution and accuracy. In this paper, we present a comprehensive overview of the innovations in rainfall observation and their popularity in different regions around the world. Then, the application value and future opportunities that new techniques bring to hydrological research are analyzed. It is anticipated that this paper will be of value to researchers with an interest in improving the quality of rainfall data, thus paving the way to accelerate these studies, as well as the application and implementation of their findings, to the next stage. Furthermore, we expect to prompt a rethink on utilizing and exploiting these new rainfall products to enhance our understanding and optimization of current rainfall sensing systems.
Role of Midlatitude Baroclinic Condition in Heavy Rainfall Events Directly Induced by Tropical Cyclones in South Korea
Authors: Park Chanil , Son Seok-Woo , Takayabu Yukari N. , Park Sang-Hun , Cha Dong-Hyun , Cha Eun Jeong 
Published: October 2023

Abstract
Recurving tropical cyclones (TCs) in the western North Pacific often cause heavy rainfall events (HREs) in East Asia. However, how their interactions with midlatitude flows alter the characteristics of HREs remains unclear. The present study examines the synoptic–dynamic characteristics of HREs directly resulting from TCs in South Korea with a focus on the role of midlatitude baroclinic condition. The HREs are categorized into two clusters based on midlatitude tropopause patterns: strongly (C1) and weakly (C2) baroclinic conditions. C1, which is common in late summer, is characterized by a well-defined trough–ridge couplet and jet streak at the tropopause. As TCs approach, the trough–ridge couplet amplifies, but is anchored by divergent TC outflow. This leads to phase locking of the upstream trough with TCs and thereby prompts substantial structural changes of TCs reminiscent of extratropical transition. The synergistic TC–midlatitude flow interactions allow for widely enhanced quasigeostrophic forcing for ascent to the north of the TC center. This allows HREs to occur even before TC landfall with more inland rainfall than C2 HREs. In contrast, C2, which is mainly observed in midsummer, does not accompany the undulating tropopause. In the absence of strong interactions with midlatitude flows, TCs rapidly dissipate after HREs while maintaining their tropical features. The upward motion is confined to the inherent TC convection, and thus HREs occur only when TCs are located in the vicinity of the country. These findings suggest that midlatitude baroclinic condition determines the spatial extent of TC rainfall and the timing of TC-induced HREs in South Korea.

Significance Statement
This study suggests that the midlatitude flows can substantially modulate heavy rainfall events directly caused by tropical cyclones. By analyzing the 42-yr tropical cyclone–induced heavy rainfall events in South Korea, it is found that tropical cyclones and midlatitude flows strongly interact with each other, especially when the midlatitude flows meander in conjunction with a strong jet stream. Their synergistic interactions result in a poleward expansion of the tropical cyclones’ precipitation shields, leading to heavy rainfall events even before they make landfall in the country. Consequently, it is advisable to carefully monitor the midlatitude conditions as well as tropical cyclones themselves as earlier heavy rainfall warnings may be necessary depending on the former.
Toward Improved Short-Term Forecasting for Lake Victoria Basin. Part I: A Radar-Based Convective Mode Analysis
Authors: del Moral Méndez Anna , Weckwerth Tammy M. , Roberts Rita D. , Wilson James W. 
Published: October 2023

Abstract
East African countries benefit economically from the largest freshwater lake in Africa: Lake Victoria (LV). Around 30 million people live along its coastline, and 5.4 million people subsist on its fishing industry. However, more than 1000 fishermen die annually by high-wave conditions often produced by severe convective wind phenomena, which marks this lake one of the deadliest places in the world for hazardous weather impacts. The World Meteorological Organization launched the 3-yr High Impact Weather Lake System (HIGHWAY) project, with the main objective to reduce loss of lives and economic goods in the lake basin and improve the resilience of the local communities. The project conducted a field campaign in 2019 aiming to provide forecasters with high-resolution observations and to study the storm life cycle over the lake basin. The research discussed here used the S-band polarimetric Tanzania radar from the field campaign to investigate the diurnal cycle of the convective mode over the lake. We classified the lake storms occurring during the two wet seasons into six different convective modes and present their diurnal evolution, organization, and main radar-based attributes, thereby extending the knowledge of convection on the lake. The result is the creation of a “convection catalog for Lake Victoria,” using the operational forecast lake sectors, and defining the exact times for the different timeslots resulting from the HIGHWAY project for the marine forecast. This will inform methods to improve the marine operational forecasts for Lake Victoria, and to provide the basis for new standard operation procedures (SOP) for severe weather surveillance and warning.

Significance Statement
In this work we use new radar data over Lake Victoria, Africa, to study convective mode organization and its diurnal cycle over the lake. This work is of particular importance due to the numerous hazardous weather events and related accidents on the lake, including capsized boats, plane crashes, floods, and hailstorms on the shore settlements, that are responsible for a high annual fatality toll. Results of our analyses provide updated information for operational marine forecasts using relevant time segments and sectors of the lake to improve nowcasting operations in Lake Victoria.
A Pilot Study: Free Flap Atrophy in Tongue Reconstruction Using 3D Volumetric Analysis
Authors: Gewirtz Jordan I. , Zhao Songzhu , Brock Guy , Luttrull Michael D. , Sethuraman Shruthi , Kang Stephen Y. , VanKoevering Kyle K. , Seim Nolan B. 
Published: October 2023

Objective: To identify factors influencing volume change in non-osseous oral free flap reconstruction using postoperative cross-sectional imaging and 3-dimensional segmentation of the free flap’s muscular and adipose tissue content. Methods: Oral tongue free flap reconstruction cases (2014-2019) were reviewed with inclusion of patients with 3 postoperative, cross-sectional imaging studies with 1 within 6 months, 1 within 1 year, and 1 that spanned 2 years post-reconstruction. Exclusion criteria included recurrence, significant dental artifact, bony reconstruction, and flap failure. Demographics, risk factors, and surgical/clinical treatments were identified. Flap volumes were measured using Materialise MIMICS. Results: Twenty-two patients met strict inclusion criteria. Four flaps were anterolateral thighs and 18 radial forearms. Median percent volume loss greater than 2 years post-reconstruction was 53.2% overall, 58.1% for radial forearms, and 45.4% for ALTs (21.4% for adipose tissue and 57.4% for muscular tissue). Univariate analysis revealed glossectomy amount was associated with percent volume loss ( P = .0417). Each successive postoperative month, the flap decreased by 1.54% ( P < .0001). Checking for the interaction effect, the percent of flap loss across time was different for glossectomy amount ( P = .0093), obesity status ( P = .0431), and base of tongue involvement ( P = .0472). Conclusion: Glossectomy type, and thus flap size, is a positive predictor for flap atrophy. Obesity and base of tongue involvement are negative predictors for flap atrophy. The amount of tissue loss may differ from classical teachings with median atrophy 53.2% greater than 2 years post-reconstruction.
Hepatic ultrastructural alterations induced by copper oxide nanoparticles: In vivo electron microscopy study
Authors: Jarrar Qais , Almansour Mansour , Jarrar Bashir , Al-Doaiss Amin , Shati Ali 
Published: October 2023

Copper oxide nanomaterials (CuO NPs) have been widely utilized in many fields, including antibacterial materials, anti-tumor, osteoporosis treatments, imaging, drug delivery, cosmetics, lubricants for metallic coating, the food industry, and electronics. Little is known about the potential risk to human health and ecosystems. The present work was conducted to investigate the ultrastructural changes induced by 20 ± 5 nm CuO NPs in hepatic tissues. Adult healthy male Wister albino rats were exposed to 36 intraperitoneal (ip) injections of 25 nm CuO NPs (2 mg/kg bw). Liver biopsies from all rats under study were processed for transmission electron microscopy (TEM) processing and examination for hepatic ultrastructural alterations. The hepatic tissue of rats exposed to repeated administrations of CuO NPs exhibited the following ultrastructural alterations: extensive mitochondrial damage in the form of swelling, crystolysis and matrix lysis, formation of phagocytized bodies and myelin multilayer figures, lysosomal hyperplasia, cytoplasmic degeneration and vacuolation, fat globules precipitation, chromatin clumping, and nuclear envelope irregularity. The findings indicated that CuO NPs interact with the hepatic tissue components and could induce alterations in the hepatocytes with the mitochondria as the main target organelles of copper nanomaterials. More work is recommended for better understanding the pathogenesis of CuO NPs.