bluuebunny/crossref_metadata_2025_split huggingface dataset:
IncRNA AC004943.2 regulates miR‐135a‐5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
Authors: Zhu Xiaowen , Dong Wenming , Zhang Meijia 
Published: February 2024

AbstractLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real‐time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were applied to detect LSCC cell viability, proliferation, migration and invasion, respectively. The interaction among AC004943.2, miR‐135a‐5p, and protein tyrosine kinase 2 (PTK2) were analyzed by bioinformatics prediction and luciferase assay. AC004943.2 was highly expressed in LSCC cells compared with normal human bronchial epithelial cells, while miR‐135a‐5p was lowly expressed. AC004943.2 knockdown or miR‐135a‐5p overexpression inhibited LSCC cell viability, proliferation, migration and invasion. Mechanistically, AC004943.2 increased PTK2 expression in LSCC cells by sponging miR‐135a‐5p. Furthermore, miR‐135a‐5p knockdown inverted the inhibitory effect of AC004943.2 silencing on LSCC cell malignant behaviors. MiR‐135a‐5p upregulation attenuated the PTK2/PI3K pathway to inhibit progression of LSCC. AC004943.2 facilitated the cancerous phenotypes of LSCC cells by activating the PTK2/PI3K pathway through targeting miR‐135a‐5p, which furnished a therapeutic candidate for LSCC treatment.
Regulation of Fluorescence and Self‐assembly of a Salicylaldehyde Azine‐Containing Amphiphile by Pillararene
Authors: Xia Danyu , Cheng Yujie , Zhang Meiru , Ma Jiaxin , Liang Bicong , Wang Pi 
Published: February 2024

AbstractRegulation of fluorescence and self‐assembly of a salicylaldehyde azine‐containing amphiphile by a water‐soluble pillar[5]arene via host–guest recognition in water was realized. The fluorescence and the self‐assembled aggregates of the bola‐type amphiphile G can be tailored by adding different amounts of water‐soluble pillar[5]arene (WP5). In addition, the emission property and self‐assembly behavior of G and WP5 are responsive to pH conditions. Furthermore, the fluorescence emission property of G and the regulation by WP5 or pH conditions was applied as information encryption material, rewritable paper, and erasable ink. We believe that this fluorescence regulation strategy is promising for the construction of advanced fluorescent organic materials.
Hydrogeochemical investigation of irrigation water in the vicinity of metallic ore deposits in Kiraz‐İzmir, Turkey: Understanding the crucial nexus between “geology and food safety”
Authors: Somay‐Altas Melis 
Published: February 2024

AbstractThe increasing drought due to climate change poses a threat to issues such as safe and accessible drinking water, food safety, and protection from diseases. The provision of water supply is vital for agricultural and livestock activities, which are commonly practiced around natural ore deposits. Examining traditional “irrigation water quality” methods alone is insufficient; investigating potentially toxic metal content in the region's waters is vital, especially around metallic ore deposits. This study focused on the Kiraz district in Turkey, known for its agricultural activities, to assess the impact of geogenic water pollution on irrigation water quality and its implications for food safety and human health. Geology determines nutrient availability, water resources, and land suitability for agriculture. Conventional irrigation water quality parameters indicate groundwater suitability for irrigation in the study area, considering Na%, sodium adsorption ratio, residual sodium carbonate, permeability index, Kelly ratio, magnesium hazard, and potential salinity. However, when examining the potential toxic metal content in the region, it was determined that the values of Al ranged from 96 to 8676 ppb, Ni values ranged from 27 to 360 ppb, and Sb concentrations varied between 9 and 53 432 ppb. Utilizing geogenically contaminated water for irrigation and its indiscriminate use in livestock, dairy, and food industries can lead to foodborne illnesses (cancer, endocrine disruptors, tuberculosis, antimony spots, thyroid tumors, goiter, neurologic and cardiovascular diseases) that endanger human health. The use of low‐quality water throughout the agricultural sector and food production chain increases food safety risks.
Safety and effectiveness of the radium‐223–taxane treatment sequence in patients with metastatic castration‐resistant prostate cancer in a global observational study (REASSURE)
Authors: Higano Celestia S. , Dizdarevic Sabina , Logue John , Richardson Timothy , George Saby , de Jong Igle , Tomaszewski Jeffrey J. , Saad Fred , Miller Kurt , Meltzer Jeffrey , Sandström Per , Verholen Frank , Tombal Bertrand , Sartor Oliver 
Published: February 2024

AbstractBackgroundRadium‐223 and taxane chemotherapy each improve survival of patients with metastatic castration‐resistant prostate cancer (mCRPC). Whether the radium‐223–taxane sequence could extend survival without cumulative toxicity was explored.MethodsThe global, prospective, observational REASSURE study (NCT02141438) assessed real‐world safety and effectiveness of radium‐223 in patients with mCRPC. Using data from the prespecified second interim analysis (data cutoff, March 20, 2019), hematologic events and overall survival (OS) were evaluated in patients who were chemotherapy‐naive at radium‐223 initiation and subsequently received taxane chemotherapy starting ≤90 days (“immediate”) or >90 days (“delayed”) after the last radium‐223 dose.ResultsFollowing radium‐223 therapy, 182 patients received docetaxel (172 [95%]) and/or cabazitaxel (44 [24%]); 34 patients (19%) received both. Seventy‐three patients (40%) received immediate chemotherapy and 109 patients (60%) received delayed chemotherapy. Median time from last radium‐223 dose to first taxane cycle was 3.6 months (range, 0.3–28.4). Median duration of first taxane was 3.7 months (range, 0–22.0). Fourteen patients (10 in the immediate and four in the delayed subgroup) had grade 3/4 hematologic events during taxane chemotherapy, including neutropenia in two patients in the delayed subgroup and thrombocytopenia in one patient in each subgroup. Median OS was 24.3 months from radium‐223 initiation and 11.8 months from start of taxane therapy.ConclusionsIn real‐world clinical practice settings, a heterogeneous population of patients who received sequential radium‐223–taxane therapy had a low incidence of hematologic events, with a median survival of 1 year from taxane initiation. Thus, taxane chemotherapy is a feasible option for those who progress after radium‐223.Clinical Trial RegistrationClinicalTrials.gov identifier NCT02141438.Plain Language Summary

Radium‐223 and chemotherapy are treatment options for metastatic prostate cancer, which increase survival but may affect production of blood cells as a side effect.
We wanted to know what would happen if patients received chemotherapy after radium‐223.
Among the 182 men treated with radium‐223 who went on to receive chemotherapy, only two men had severe side effects affecting white blood cell production (neutropenia) during chemotherapy.
On average, the 182 men lived for 2 years after starting radium‐223 and 1 year after starting chemotherapy.
In conclusion, patients may benefit from chemotherapy after radium‐223 treatment without increasing the risk of side effects.
Ivosidenib significantly reduces triazole levels in patients with acute myeloid leukemia and myelodysplastic syndrome
Authors: Dinh Ashley , Savoy J. Michael , Kontoyiannis Dimitrios P. , Takahashi Koichi , Issa Ghayas C. , Kantarjian Hagop M. , DiNardo Courtney D. , Rausch Caitlin R. 
Published: February 2024

AbstractBackgroundIvosidenib is primarily metabolized by CYP3A4; however, it induces CYP450 isozymes, including CYP3A4 and CYP2C9, whereas it inhibits drug transporters, including P‐glycoprotein. Patients with acute myeloid leukemia are at risk of invasive fungal infections, and therefore posaconazole and voriconazole are commonly used in this population. Voriconazole is a substrate of CYP2C9, CYP2C19, and CYP3A4; therefore, concomitant ivosidenib may result in decreased serum concentrations. Although posaconazole is a substrate of P‐glycoprotein, it is metabolized primarily via UDP glucuronidation; thus, the impact of ivosidenib on posaconazole exposure is unknown.MethodsPatients treated with ivosidenib and concomitant triazole with at least one serum trough level were included. Subtherapeutic levels were defined as posaconazole <700 ng/mL and voriconazole <1.0 µg/mL. The incidences of breakthrough invasive fungal infections and QTc prolongation were identified at least 5 days after initiation of ivosidenib with concomitant triazole.ResultsSeventy‐eight serum triazole levels from 31 patients receiving ivosidenib‐containing therapy and concomitant triazole were evaluated. Of the 78 concomitant levels, 47 (60%) were subtherapeutic (posaconazole: n = 20 of 43 [47%]; voriconazole: n = 27 of 35 [77%]). Compared to levels drawn while patients were off ivosidenib, median triazole serum levels during concomitant ivosidenib were significantly reduced. There was no apparent increase in incidence of grade 3 QTc prolongation with concomitant azole antifungal and ivosidenib 500 mg daily.ConclusionsThis study demonstrated that concomitant ivosidenib significantly reduced posaconazole and voriconazole levels. Voriconazole should be avoided, empiric high‐dose posaconazole (>300 mg/day) may be considered, and therapeutic drug monitoring is recommended in all patients receiving concomitant ivosidenib.
Cr‐ and Ga‐Modified ZSM‐5 Catalyst for the Production of Renewable BTX from Bioethanol
Authors: Saini Swati , Oluokun Tolulope , Sharma Bhawna , Verma Akash , Vorontsov Alexander , Smirniotis Panagiotis G. , Singh Raghuvir , Viswanadham Nagabhatla , Kumar Umesh 
Published: February 2024

AbstractLight aromatics (benzene, toluene, and xylene, collectively known as BTX) are essential commodity chemicals in the petrochemical industry. The present study examines the aromatization of bioethanol with Cr‐ and Ga‐modified ZSM‐5. Both Cr and Ga were incorporated by the ion‐exchange method. Cr‐modified ZSM‐5 outperforms the Ga‐modified ZSM‐5 and H‐ZSM‐5 catalysts. Cr−H‐ZSM‐5 almost doubled the carbon yield of aromatics compared to H‐ZSM‐5 at an optimum reaction temperature of 450 °C. Cr−H‐ZSM‐5 produced aromatics with a yield of ~40 %. The effect of dilution in feed on BTX production is also studied. Cr−H‐ZSM‐5 was found to be more active than H‐ZSM‐5. Complete ethanol conversion was obtained with both pure and dilute bioethanol. The Bronsted‐Lewis acid (BLA) pair formed after metal incorporation is responsible for dehydrogenation followed by aromatization, leading to increased aromatic production.
Copper Vacancy and LSPR‐Activated MXene Synergistically Enabling Selective Photoreduction CO2 to Acetate
Authors: Liao Chen , Zhou Hongwei , Zhang Shunxin , Wang Feng , Liu Ya , Guo Liejin 
Published: February 2024

AbstractPhotocatalytic CO2 conversion towards C2+ fuels is a promising technology for simultaneously achieving carbon neutrality and alleviating the energy crisis. However, this strategy is inefficient due to the difficulty of both multi‐electron transfer and C−C coupling during C2+ formation. In this work, CuInS2/MXene heterostructure with Cu vacancy is rationally designed by in situ hydrothermal synthesis. The VCu−CuInS2/MXene heterostructure has a suitable band structure and tight interface contact. Catalytic performances under different testing conditions, in situ spectroscopy, and COMSOL simulation reveal that LSPR‐activated MXene promotes the formation of crucial intermediate CH2* and triggers the C−C coupling process under near‐infrared light, as the key to acetate. Moreover, in situ XPS analysis, DFT calculations, and photoelectrochemical characterizations unveil that copper vacancy can promote charge transfer from CuInS2 to MXene and boost local electron aggregation on the MXene, further enhancing the photocatalytic efficiency and selectivity of C2 products. Contributing to the synergistic effect of copper vacancy and plasmonic MXene, VCu−CuInS2/MXene achieved excellent CO2RR activity with an acetate evolution rate of 250.0 μmol/h/g and a selectivity of 97.5 % under the full spectrum irradiation, which is 38.8 and 3.3 times higher than that of VCu−CuInS2 and CuInS2/MXene, respectively.
Differences between Riemann–Liouville and Caputo calculus definitions in analyzing fractional boost converter with discontinuous‐conduction‐mode operation
Authors: Chen Yanfeng , Wang Xin , Zhang Bo , Xie Fan , Chen Sheng 
Published: February 2024

SummaryFractional‐order calculus is an extension of the integer‐order calculus in that its order is not limited to integers but can be noninteger as well, thus making the application of fractional‐order calculus more flexible. It has been shown that actual reactive elements such as capacitors and inductors have fractional‐order properties and that the theory of fractional‐order calculus can be utilized to more accurately characterize circuits and systems containing reactive elements. However, there is no uniform definition of fractional order calculus. Different definitions will yield different results in solving the same fractional‐order circuits and systems, and it is worth exploring whether these differences have an impact on the accuracy of solving fractional‐order systems. Taking a fractional‐order boost converter running in discontinuous conduction mode (DCM) as an example, this paper focuses on the differences between the Riemann–Liouville (R–L) and the Caputo fractional calculus definitions. Effects of the two definitions on the division of the converter's CCM (continuous conduction mode) and DCM operating regions are analyzed, as well as their impact on the characterization of a fractional‐order boost converter in DCM operation, including the DC (direct current) operating point, current ripple, and voltage gain. Simulations and experiments show that the analytical results based on the R–L definition can more accurately describe the operation of a real fractional‐order converter than those based on the Caputo definition.
Letter to the Editor: Does fetal movement shape the maternal brain?
Authors: Ayala Kathy , Voegtline Kristin , Rutherford Helena JV 
Published: February 2024

AbstractHere, we debate that fetal behavior may contribute to the dynamic changes observed in the maternal brain during the perinatal period. We call for future research to explore this perspective to understand the complex maternal–fetal relationship and how fetal signals influence the preparation for parenthood.
Plasma‐derived exosomal miRNA profiles associated with type 1 diabetes
Authors: Pang Haipeng , Fan Wenqi , Pi Linhua , Shi Xiajie , Wang Zhen , Luo Shuoming , Xiao Yang , Li Xia , Huang Gan , Xie Zhiguo , Zhou Zhiguang 
Published: February 2024

AbstractAimsRecently, exosomal miRNAs have been shown to play important roles in multiple diseases, including type 1 diabetes (T1D). To assess the biomarker potential of exosomal miRNAs for T1D, we measured the expression profiles of plasma‐derived exosomal miRNAs in T1D and explored their potential functions by bioinformatic analysis.Materials and methodsIn the discovery phase, exosome samples were isolated from plasma by size exclusion chromatography from 10 T1D patients and 10 sex‐ (p = 0.36), age‐ (p = 0.97), and body mass index‐matched (p = 0.47) healthy control subjects. Exosomal miRNA expression profiles were measured using the Illumina NovaSeq 6000 platform. With verification by quantitative real‐time PCR (qRT‒PCR), we used multiple bioinformatics approaches to explore the potential biological functions of the identified differentially expressed miRNAs. The diagnostic signature of exosomal miRNAs was evaluated by least absolute shrinkage and selection operator (LASSO) regression and evaluated based on the area under the receiver operating characteristic curve (AUC).ResultsIn total, 43 differentially expressed miRNAs, among which 34 were upregulated and 9 were downregulated, were identified in T1D. After correcting for multiple testing using false discovery rate, 11 identified exosomal miRNAs still showed statistical significance. Among the 5 selected miRNAs, 3 miRNAs (miR‐103a‐3p, miR‐144‐5p and miR‐454‐3p) were successfully validated by qRT‒PCR. The biological analysis‐enriched terms included protein autophosphorylation and the Hedgehog signalling pathway. The highest AUC of exosomal miRNA was 0.889 under the LASSO model. The expression levels of 5 selected exosomal miRNAs were correlated with multiple clinical characteristics such as fasting C‐peptide and postprandial C‐peptide.ConclusionsOur results indicated that plasma‐derived exosomal miRNAs could serve as promising diagnostic biomarkers of T1D.
The impact of sodium‐glucose co‐transporter‐2 inhibitors on dementia and cardiovascular events in diabetic patients with atrial fibrillation
Authors: Chen Yun‐Yu , Chang Hao‐Chih , Lin Yenn‐Jiang , Chien Kuo‐Liong , Hsieh Yu‐Cheng , Chung Fa‐Po , Lin Ching‐Heng , Lip Gregory Y. H. , Chen Shih‐Ann 
Published: February 2024

AbstractAimsThe effectiveness of sodium‐glucose co‐transporter‐2 inhibitors (SGLT2i) on incident dementia in patients with diabetes and atrial fibrillation (AF) remains unknown. This study aimed to investigate the association between SGLT2i and the risk of incident dementia in diabetic patients with AF, and to explore the interactions with oral anticoagulants or dipeptidyl peptidase‐4 inhibitors (DPP4i).Materials and MethodsWe conducted a cohort study using Taiwan's National Health Insurance Research Database. Patients with diabetes and AFwithout a prior history of established cardiovascular diseases, were identified. Using propensity score matching, 810 patients receiving SGLT2i were matched with 1620 patients not receiving SGLT2i. The primary outcome was incident dementia, and secondary outcomes included composite cardiovascular events and mortality.ResultsAfter up to 5 years of follow‐up, SGLT2i use was associated with a significantly lower risk of incident dementia (hazard: 0.71, 95% confidence interval: 0.51–0.98), particularly vascular dementia (HR: 0.44, 95% CI: 0.24–0.82). SGLT2i was related to reduced risks of AF‐related hospitalisation (HR: 0.72, 95% CI: 0.56–0.93), stroke (HR: 0.75, 95% CI: 0.60–0.94), and all‐cause death (HR: 0.33, 95% CI: 0.24–0.44). The protective effects were consistent irrespective of the concurrent use of non‐vitamin K antagonist oral anticoagulants (NOACs) or DPP4i.ConclusionsIn diabetic patients with AF, SGLT2i was associated with reduced risks of incident dementia, AF‐related hospitalisation, stroke, and all‐cause death. The protective effects were independent of either concurrent use of NOACs or DPP4i.
Drivers of geophagy by red brocket deer (Mazama americana) at Amazonian interior forest mineral licks
Authors: Griffiths Brian M. , Griffiths Lesa G. , Jin Yan , Gilmore Michael P. 
Published: February 2024

AbstractMineral licks are key ecological components of the Amazon rainforest, providing critical dietary functions for herbivorous and frugivorous mammals and birds, which help maintain the structure and function of the forest itself through seed and nutrient dispersal. One of the most frequent visitors of interior forest mineral licks in the Amazon is the red brocket deer (Mazama americana), a large‐bodied ruminant frugivore and seed predator. While several hypotheses for the drivers of geophagy exist, including mineral supplementation, toxin adsorption, and habitat selection, robust data on geophagy for the red brocket deer for large numbers of mineral licks is nonexistent. We used soil data from 83 mineral licks in conjunction with camera trap data from 52 of those mineral licks and a mixed‐effects modeling approach to test the three proposed hypotheses of geophagy for the red brocket deer. We found that consumed soils at mineral licks had elevated concentrations of almost all major and minor biologically active minerals measured, including Ca, Na, Mg, K, Cu, Zn, and Mn. Model results suggest that all three hypotheses hold true to some extent for the red brocket deer, with the greatest support for the mineral supplementation hypothesis, in particular with respect to Mg, Ca, Na, Cu, and Zn. This study provides critical information on the feeding ecology of the red brocket deer in the wild, and the first robust analysis of geophagy of an Amazonian mammal involving a large sample size of interior forest mineral licks.
Arthropod diversity in the alpine tundra using metabarcoding: Spatial and temporal differences in alpha‐ and beta‐diversity
Authors: Hein Nils , Astrin Jonas J. , Beckers Niklas , Giebner Hendrik , Langen Kathrin , Löffler Jörg , Misof Bernhard , Fonseca Vera G. 
Published: February 2024

AbstractAll ecosystems face ecological challenges in this century. Therefore, it is becoming increasingly important to understand the ecology and degree of local adaptation of functionally important Arctic‐alpine biomes by looking at the most diverse taxon of metazoans: the Arthropoda. This is the first study to utilize metabarcoding in the Alpine tundra, providing insights into the effects of micro‐environmental parameters on alpha‐ and beta‐diversity of arthropods in such unique environments. To characterize arthropod diversity, pitfall traps were set at three middle‐alpine sampling sites in the Scandinavian mountain range in Norway during the snow‐free season in 2015. A metabarcoding approach was then used to determine the small‐scale biodiversity patterns of arthropods in the Alpine tundra. All DNA was extracted directly from the preservative EtOH from 27 pitfall traps. In order to identify the controlling environmental conditions, all sampling locations were equipped with automatic data loggers for permanent measurement of the microenvironmental conditions. The variables measured were: air temperature [°C] at 15 cm height, soil temperature [°C] at 15 cm depth, and soil moisture [vol.%] at 15 cm depth. A total of 233 Arthropoda OTUs were identified. The number of unique OTUs found per sampling location (ridge, south‐facing slope, and depression) was generally higher than the OTUs shared between the sampling locations, demonstrating that niche features greatly impact arthropod community structure. Our findings emphasize the fine‐scale heterogeneity of arctic–alpine ecosystems and provide evidence for trait‐based and niche‐driven adaptation. The spatial and temporal differences in arthropod diversity were best explained by soil moisture and soil temperature at the respective locations. Furthermore, our results show that arthropod diversity is underestimated in alpine‐tundra ecosystems using classical approaches and highlight the importance of integrating long‐term functional environmental data and modern taxonomic techniques into biodiversity research to expand our ecological understanding of fine‐ and meso‐scale biogeographical patterns.