bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Effect of drain placement in short‐level spinal surgery on postoperative wound infection: A meta‐analysis
Authors: Zhan Baoming , Fang Shiqiang , Lv Xiuhong , Xie Xuesheng , Wang Xing 
Published: December 2023

AbstractIn the meta‐analysis, we evaluated the efficacy of placing drainage channels following single‐ or double‐level spine surgery in order to decrease the incidence of postoperative injury. We conducted the analysis with the help of four databases: PubMed, Embase, Cochrane Library and Web of Science. A review of related studies was carried out after evaluating the quality of the literature against the classification and exclusion criteria set for the trial. Calculation of 95% CI, OR and MD was performed with fixed‐effect models. A meta‐analysis of the data was carried out with RevMan 5.3. Meta‐analyses of randomized controlled trial (RCT) did not indicate that there were a statistically significantly different incidence of postoperative wound infections among those who received drainage compared to those who did not receive drainage (OR, 2.29; 95% CI, 0.50, 10.41 p = 0.28). Moreover, there were no statistically significant differences in post‐operation hematoma (OR, 1.20; 95% CI, 0.27, 5.28 p = 0.81) and visual analogue scale score (MD, −0.01; 95% CI, −1.34, 1.33 p = 0.99). Thus, placing drainage in short‐levels of spine operation did not significantly influence the outcome of postoperative wound complications. Nevertheless, because of the limited sample size chosen for this meta‐analysis, caution should be exercised when treating these data. More high‐quality RCT trials with a large number of samples are required to confirm the findings.
Primary care nurse's role and educational preparedness in skin cancer screening and early detection: A scoping review
Authors: Beames Chelsea , Adelson Pamela , Sharplin Greg , Eckert Marion 
Published: December 2023

AbstractAimTo identify the available evidence regarding nursing roles in skin cancer screening and early detection and the reported education and training undertaken to do so.DesignScoping review, reported in accordance with PRISMA‐ScR.Data SourcesA database search of Medline, CINAHL, Scopus, Embase, Emcare and JBI was conducted in November 2021. A grey literature search was conducted in February 2022. Searches were updated in August 2023.Review MethodsThe data were extracted and synthesized into themes related to nursing roles and education.ResultsOf the 2285 identified studies, 54 were included in the review. Nursing roles included screening and early detection, prevention and patient education or counselling. Except for specialized nurse practitioners, nurses working in primary clinical care mostly engage in skin cancer supportive/administrative roles rather than leading collaborators in screening and early detection. The education and training for nurses were identified around themes of didactic education, clinical experience, training in dermoscopy, performance and knowledge assessment and self‐efficacy.ConclusionThe roles and responsibilities of nurses working in skin cancer screening and early detection are highly variable, as are the reported training and education programmes. Little research has been conducted to explore this nursing role or the educational requirements needed for proficiency. With appropriate best practice education, it is within most primary care nurses’ scope of practice to obtain competence in delivering opportunistic skin cancer screening.Impact

While most nurse specialists in dermatology will be proficient in dermoscopy and skin cancer screening, nurses who work in general practice are often underutilized due to a lack of opportunity and a clear pathway to becoming proficient in dermoscopic skin cancer screening.

Most nurses involved in skin cancer screening are employed in advanced roles, and only a few studies investigating educational interventions utilized dermoscopy among advanced nurses.

With specific training, nurses can work within their full scope of practice and increase access to skin cancer screening and early detection.

Reporting MethodAdhered to JBI Guidance for Conducting Systematic Scoping Reviews.Protocol RegistrationOpen Science Framework, https://doi.org/10.17605/OSF.IO/XUNE6Patient or Public ContributionN/A; a literature review.
m6A‐related lncRNAs as potential biomarkers and the lncRNA ELFN1‐AS1/miR‐182‐5p/BCL‐2 regulatory axis in diffuse large B‐cell lymphoma
Authors: Yang Qinglong , Lu Yingxue , Du Ashuai 
Published: December 2023

AbstractDiffuse large B‐cell lymphoma (DLBCL) is the most common lymphoid subtype. However, unsatisfactory survival outcomes remain a major challenge, and the underlying mechanisms are poorly understood. N6‐methyladenosine (m6A), the most common internal modification of eukaryotic mRNA, participates in cancer pathogenesis. In this study, m6A‐associated long non‐coding RNAs (lncRNA) were retrieved from publicly available databases. Univariate, LASSO, and multivariate Cox regression analyses were performed to establish an m6A‐associated lncRNA model specific to DLBCL. Kaplan–Meier curves, principal component analysis, functional enrichment analyses and nomographs were used to study the risk model. The underlying clinicopathological characteristics and drug sensitivity predictions against the model were identified. Risk modelling based on the three m6A‐associated lncRNAs was an independent prognostic factor. By regrouping patients using our model‐based method, we could differentiate patients more accurately for their response to immunotherapy. In addition, prospective compounds that can target DLBCL subtypes have been identified. The m6A‐associated lncRNA risk‐scoring model developed herein holds implications for DLBCL prognosis and clinical response prediction to immunotherapy. In addition, we used bioinformatic tools to identify and verify the ceRNA of the m6A‐associated lncRNA ELFN1‐AS1/miR‐182‐5p/BCL‐2 regulatory axis. ELFN1‐AS1 was highly expressed in DLBCL and DLBCL cell lines. ELFN1‐AS1 inhibition significantly reduced the proliferation of DLBCL cells and promoted apoptosis. ABT‐263 inhibits proliferation and promotes apoptosis in DLBCL cells. In vitro and in vivo studies have shown that ABT‐263 combined with si‐ELFN1‐AS1 can inhibit DLBCL progression.
Genetic mutations and phenotype characteristics in peripheral vascular malformations: A systematic review
Authors: Stor M. L. E. , Horbach S. E. R. , Lokhorst M. M. , Tan E. , Maas S. M. , van Noesel C. J. M. , van der Horst C. M. A. M. 
Published: December 2023

AbstractVascular malformations (VMs) are clinically diverse with regard to the vessel type, anatomical location, tissue involvement and size. Consequently, symptoms and disease impact differ significantly. Diverse causative mutations in more and more genes are discovered and play a major role in the development of VMs. However, the relationship between the underlying causative mutations and the highly variable phenotype of VMs is not yet fully understood. In this systematic review, we aimed to provide an overview of known causative mutations in genes in VMs and discuss associations between the causative mutations and clinical phenotypes. PubMed and EMBASE libraries were systematically searched on November 9th, 2022 for randomized controlled trials and observational studies reporting causative mutations in at least five patients with peripheral venous, lymphatic, arteriovenous and combined malformations. Study quality was assessed with the Newcastle‐Ottawa Scale. Data were extracted on patient and VM characteristics, molecular sequencing method and results of molecular analysis. In total, 5667 articles were found of which 69 studies were included, reporting molecular analysis in a total of 4261 patients and 1686 (40%) patients with peripheral VMs a causative mutation was detected. In conclusion, this systematic review provides a comprehensive overview of causative germline and somatic mutations in various genes and associated phenotypes in peripheral VMs. With these findings, we attempt to better understand how the underlying causative mutations in various genes contribute to the highly variable clinical characteristics of VMs. Our study shows that some causative mutations lead to a uniform phenotype, while other causal variants lead to more varying phenotypes. By contrast, distinct causative mutations may lead to similar phenotypes and result in almost indistinguishable VMs. VMs are currently classified based on clinical and histopathology features, however, the findings of this systematic review suggest a larger role for genotype in current diagnostics and classification.
Comparison of gut bacterial communities ofOedaleus decorus asiaticus(Orthoptera: Acrididae) ingesting on different grasses
Authors: Ma Yaling , Yu Binhua , Wang Zhiye 
Published: December 2023

AbstractMicrobiota that live in gut of the insects have a wide range of effects on host physiology, nutrition, and behaviour. To characterize the gut bacterial community of orthopteran pests comprehensively, we selectedOedaleus decorus asiaticus as a representative pest to more explicitly test the influence of host dietary niche on the gut bacterial community. Illumina high‐throughput sequencing technology was used to study the gut bacterial community ofO. d. asiaticus, a key pest on natural grasslands in China. The results showed that the gut bacterial community ofO. d. asiaticusingesting on Poa poophagorum had the highest diversity but lowest richness, and Proteobacteria and Firmicutes were dominant phylum. There were significant differences in the gut bacterial structure ofO. d. asiaticusafter ingesting different grasses. Most of functional prediction pathways were concentrated in metabolism and cellular processes. The diversity of the gut bacterial community associated withCarex sutschanensis,Sipapurpurea, andAgropyron cristatumwas positively associated with crude protein (Ca) (p < 0.05), phosphorus (P) (p < 0.05), and ether extract (EE) (p < 0.05). The abundance ofPantoea,Wolbachia,Enterobacter,Escherichia, andEnterococcuswas positively related to P and EE. The abundance ofPantoea,Wolbachia,Enterobacter,Enterococcus,Succiniclasticum,Lactobacillus, andAcinetobacterwas positively related to crude protein. The abundance ofEscherichia,Muribaculum,Succiniclasticum,Lactobacillus,Acinetobacterwas positively related to Ca and dry matter. The abundance ofMuribaculum,Succiniclasticum,Lactobacillus,Acinetobacterwas positively related to acid detergent fibre, neutral detergent fibre, and crude ash. These results suggest that the grass with higher overall nutritional content has higher abundance of immune bacteria. This investigation of the gut bacterial community may provide insights into the relationships between grasses, pests, and their gut bacterial communities, and find new ways to control locust outbreaks by targeting the insect bacterial community.
Memory performance mediates subjective sleep quality associations with cerebrospinal fluid Alzheimer's disease biomarker levels and hippocampal volume among individuals with mild cognitive symptoms
Authors: Stankeviciute Laura , Blackman Jonathan , Tort‐Colet Núria , Fernández‐Arcos Ana , Sánchez‐Benavides Gonzalo , Suárez‐Calvet Marc , Iranzo Álex , Molinuevo José Luis , Gispert Juan Domingo , Coulthard Elizabeth , Grau‐Rivera Oriol 
Published: December 2023

SummarySleep disturbances are prevalent in Alzheimer's disease (AD), affecting individuals during its early stages. We investigated associations between subjective sleep measures and cerebrospinal fluid (CSF) biomarkers of AD in adults with mild cognitive symptoms from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study, considering the influence of memory performance. A total of 442 participants aged >50 years with a Clinical Dementia Rating (CDR) score of 0.5 completed the Pittsburgh Sleep Quality Index questionnaire and underwent neuropsychological assessment, magnetic resonance imaging acquisition, and CSF sampling. We analysed the relationship of sleep quality with CSF AD biomarkers and cognitive performance in separated multivariate linear regression models, adjusting for covariates. Poorer cross‐sectional sleep quality was associated with lower CSF levels of phosphorylated tau and total tau alongside better immediate and delayed memory performance. After adjustment for delayed memory scores, associations between CSF biomarkers and sleep quality became non‐significant, and further analysis revealed that memory performance mediated this relationship. In post hoc analyses, poorer subjective sleep quality was associated with lesser hippocampal atrophy, with memory performance also mediating this association. In conclusion, worse subjective sleep quality is associated with less altered AD biomarkers in adults with mild cognitive symptoms (CDR score 0.5). These results could be explained by a systematic recall bias affecting subjective sleep assessment in individuals with incipient memory impairment. Caution should therefore be exercised when interpreting subjective sleep quality measures in memory‐impaired populations, emphasising the importance of complementing subjective measures with objective assessments.
Urine sodium concentration after intravenous furosemide in dogs with acute congestive heart failure and correlation with treatment efficacy
Authors: Convey Victoria , Huh Terry , Achilles Erin J. , Massey Laura K. , McKaba Victoria F. , Loughran Kerry A. , Kraus Marc S. , Gelzer Anna R. , Crooks Alexandra V. , Oyama Mark A. 
Published: December 2023

AbstractBackgroundPoor natriuresis is a potential marker of diuretic resistance in dogs with acute congestive heart failure (CHF) but little is known about the relationship between urine sodium concentration (uNa) and frequency of successful decongestion. Supplemental O2 is a common treatment in dogs with severe CHF. The time from start to discontinuation of supplemental O2 therapy (DCSO2) typically reflects the time course and ease of decongestion.Hypothesis/ObjectivesUrine Na concentration after IV administration of furosemide will be correlated with duration of treatment with supplemental O2 (timeO2) and the cumulative frequency of successful DCSO2 during hospitalization.AnimalsFifty‐one dogs with acute CHF.MethodsRetrospective observational single center study.ResultsDogs with low uNa had significantly longer mean timeO2 than dogs with high uNa (uNa <87 mmol/L, 24.2 ± 2.6 hours vs uNa ≥87 mmol/L, 16.6 ± 1.7 hours; P = .02). Low uNa was correlated with lower cumulative frequency of DCSO2 (12 hour, 28%; 24 hour, 42%; 36 hour, 73%) compared to high uNa (12 hour, 28%; 24 hour, 88%; 36 hour, 96%; P = .005). History of PO loop diuretics, low serum chloride concentration (sCl), and high PCV were associated with low uNa. Urine Na concentration outperformed other metrics of diuretic responsiveness including weight loss.Conclusions and Clinical ImportanceUrine Na concentration after IV furosemide predicted timeO2 and cumulative frequency of DCSO2 in dogs with acute CHF, which likely reflects important aspects of diuretic responsiveness. Urine Na can assess diuretic responsiveness and treatment efficacy in dogs with CHF.
Common and atypical presentations of Anaplasma phagocytophilum infection in equids with emphasis on neurologic and muscle disease
Authors: Aleman Monica , Vedavally Ujwala , Pusterla Nicola , Wensley Fiona , Berryhill Emily , Madigan John E. 
Published: December 2023

AbstractBackgroundComprehensive descriptions of equids with granulocytic anaplasmosis (EGA) with neurologic or muscle disease and other atypical presentations are scarce in the literature.ObjectiveDescribe the clinical signs, laboratory findings, treatment, and outcome of equids with EGA with emphasis on neurologic and muscle disease.AnimalsThirty‐eight horses, 1 donkey.MethodsRetrospective study. Equids with EGA were included. The electronic data base was searched from January 2000 to December 2022 using the words anaplasmosis, ehrlichiosis, granulocytic, and rickettsia. Signalment and clinical data were reviewed. Data were evaluated for normality using Shapiro‐Wilk test. Parametric and nonparametric statistics were used for normally and non‐normally distributed data.ResultsCommon (41%) and other (59%) presentations were seen in horses ≥ 4 years of age (median, 14 years) with an overrepresentation of males (77%). Neurologic disease was common (41%), mainly presenting as diffuse symmetrical proprioceptive ataxia. Brain disease was less common manifesting as obtundation and cranial nerve deficits. Muscle disease was less common, with QH breeds with the variant causing myosin heavy chain myopathy (MYHM) having severe disease. Cavitary effusion, cardiomyopathy and disseminated intravascular coagulation (DIC) were uncommon. Clinical laboratory results varied depending on disease stage. Muscle enzyme activities were significantly higher in horses with muscle disease. Outcome was favorable with prompt tetracycline treatment. Death and long‐term sequelae were not reported.Conclusions and Clinical ImportanceCommon and atypical presentations of EGA have a favorable outcome with prompt tetracycline treatment. Quarter horse breeds with muscle disease should be genotyped for MYHM.
Genetic and molecular landscapes of the generalist phytopathogen Botrytis cinerea
Authors: Singh Ritu , Caseys Celine , Kliebenstein Daniel J. 
Published: December 2023

AbstractBotrytis cinerea Pers. Fr. (teleomorph: Botryotinia fuckeliana) is a necrotrophic fungal pathogen that attacks a wide range of plants. This updated pathogen profile explores the extensive genetic diversity of B. cinerea, highlights the progress in genome sequencing, and provides current knowledge of genetic and molecular mechanisms employed by the fungus to attack its hosts. In addition, we also discuss recent innovative strategies to combat B. cinerea.TaxonomyKingdom: Fungi, phylum: Ascomycota, subphylum: Pezizomycotina, class: Leotiomycetes, order: Helotiales, family: Sclerotiniaceae, genus: Botrytis, species: cinerea.Host rangeB. cinerea infects almost all of the plant groups (angiosperms, gymnosperms, pteridophytes, and bryophytes). To date, 1606 plant species have been identified as hosts of B. cinerea.Genetic diversityThis polyphagous necrotroph has extensive genetic diversity at all population levels shaped by climate, geography, and plant host variation.PathogenicityGenetic architecture of virulence and host specificity is polygenic using multiple weapons to target hosts, including secretory proteins, complex signal transduction pathways, metabolites, and mobile small RNA.Disease control strategiesEfforts to control B. cinerea, being a high‐diversity generalist pathogen, are complicated. However, integrated disease management strategies that combine cultural practices, chemical and biological controls, and the use of appropriate crop varieties will lessen yield losses. Recently, studies conducted worldwide have explored the potential of small RNA as an efficient and environmentally friendly approach for combating grey mould. However, additional research is necessary, especially on risk assessment and regulatory frameworks, to fully harness the potential of this technology.
New species and new record of the genus Poa L. (Poaceae, Pooideae, Poeae) from India
Authors: Sharma Sangam , Prasad Dileshwar , Jaiswal Shubham , Agnihotri Priyanka 
Published: December 2023

Poa sachensis, a new species from the Sach Pass, Western Himalaya, is described and illustrated. It is a member of P. subg. Ochlopoa sect. Alpinae, and closely allied to P. alpina, but differs from the latter by its lower glume one‐nerved, callus scantly hairy, lemma (3.87–) 4.18–4.54 (–4.65) mm long, purplish, surface between nerves glabrous, palea proliferate and keels ciliate 1/2nd to 1/3rd part, and two stamens in fertile floret with anther (2.42–) 2.67–3.08 (–3.21) mm long. Further, we have added P. diaphora var. alpina for the first time to the flora of India based on specimens collected from the semiarid habitats of Spiti Valley. Information on the distribution, habitat, flowering, and fruiting cycles is provided along with a distribution map for each taxon.Keywords: alpine grasses, Poa alpina, P. subg. Pseudopoa, P. subg. Ochlopoa, Western Himalaya
Sir2‐mediated cytoplasmic deacetylation facilitates pathogenic fungi infection in host plants
Authors: Zhang Ning , Hu Jicheng , Liu Zhishan , Liang Wenxing , Song Limin 
Published: December 2023

Summary
Lysine acetylation is an evolutionarily conserved and widespread post‐translational modification implicated in the regulation of multiple metabolic processes, but its function remains largely unknown in plant pathogenic fungi.
A comprehensive analysis combined with proteomic, molecular and cellular approaches was presented to explore the roles of cytoplasmic acetylation in Fusarium oxsysporum f.sp. lycopersici (Fol).
The divergent cytoplasmic deacetylase FolSir2 was biochemically characterized, which is contributing to fungal virulence. Based on this, a total of 1752 acetylated sites in 897 proteins were identified in Fol via LC–MS/MS analysis. Further analyses of the quantitative acetylome revealed that 115 proteins representing two major pathways, translational and ribosome biogenesis, were hyperacetylated in the ∆Folsir2 strain. We experimentally examined the regulatory roles of FolSir2 on K271 deacetylation of FolGsk3, a serine/tyrosine kinase implicated in a variety of cellular functions, which was found to be crucial for the activation of FolGsk3 and thus modulated Fol pathogenicity. Cytoplasmic deacetylation by FolSir2 homologues has a similar function in Botrytis cinerea and likely other fungal pathogens.
These findings reveal a conserved mechanism of silent information regulator 2‐mediated cytoplasmic deacetylation that is involved in plant‐fungal pathogenicity, providing a candidate target for designing broad‐spectrum fungicides to control plant diseases.
Group‐specific redistribution, inequality, and subjective well‐being in China
Authors: Deng Peihua , Schöb Ronnie 
Published: December 2023

AbstractUsing survey data from the China Family Panel Studies (CFPS) from 2010 to 2018, this paper analyzes the relationship between income inequality, group‐specific income redistribution, and subjective well‐being among China's urban, rural, and migrant populations. Income redistribution significantly reduces the within‐group inequality for urban residents while widening the income gap among urban residents, rural residents, and migrants. Using narrowly defined reference groups, our findings indicate that there is no significant correlation of within‐group inequality and subjective well‐being of the respective group members. By contrast, the increased income gap between urban and rural residents is positively correlated with the rural residents' subjective well‐being. More importantly, the group‐specific redistribution inherent in the Hukou system that widens the income gap between urban residents and both migrants and rural residents makes both the aforementioned worse off. The existing Hukou system thus bars the way to implement the concept of “common prosperity” of the Chinese government that aims to foster a more balanced and sustainable development.