bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Sodium Bicarbonate and Bone Turnover in CKD: A Secondary Analysis of the BASE Pilot Trial
Authors: Raphael Kalani L. , Katz Ronit , Larive Brett , Kendrick Cynthia , Isakova Tamara , Sprague Stuart , Wolf Myles , Raj Dominic S. , Fried Linda F. , Gassman Jennifer , Hoofnagle Andy , Cheung Alfred K. , Ix Joachim H. 
Published: December 2023

Significance Statement
In CKD, metabolic acidosis is commonly treated with alkali in the hope that it will improve bone health. In a post hoc analysis of the Bicarbonate Administration to Stabilize eGFR Pilot Trial, we investigated whether sodium bicarbonate affects serum levels of bone turnover markers and other hormones related to bone health in individuals with CKD who have normal to slightly reduced total CO2 (20–28 mEq/L). Sodium bicarbonate increased serum levels of α-klotho but had no significant effect on other bone health markers, including intact fibroblast growth factor-23 (iFGF-23), intact parathyroid hormone (iPTH), and bone-specific alkaline phosphatase (B-SAP). Further study is needed to determine the effect of bicarbonate administration on clinical aspects of bone health.

Background
Treatment with alkali has been hypothesized to improve bone health in CKD by mitigating adverse effects of acid on bone mineral. We investigated the effect of treatment with sodium bicarbonate on bone turnover markers and other factors related to bone metabolism in CKD.

Methods
This is a post hoc analysis of the Bicarbonate Administration to Stabilize eGFR Pilot Trial in which 194 individuals with CKD and serum total CO2 20–28 mEq/L were randomly assigned to placebo or one of two doses of sodium bicarbonate (0.5 or 0.8 mEq/kg lean body weight per day) for 28 weeks. The following serum measurements were performed at baseline, week 12, and week 28: B-SAP, c-telopeptide, procollagen type I intact N-terminal propeptide, iPTH, iFGF-23, soluble klotho, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and tartrate-resistant acid phosphatase 5b. The difference (sodium bicarbonate versus placebo) in mean change of each bone biomarker from baseline was determined using linear mixed models.

Results
One hundred sixty-eight participants submitted samples for post hoc investigations. Mean eGFR was 37±10 ml/min per 1.73 m2 and mean total CO2 was 24±3 mEq/L at baseline. Sodium bicarbonate induced a dose-dependent increase in soluble klotho levels compared with placebo. There was no significant effect of treatment with either dose of sodium bicarbonate on any of the other bone biomarkers, including iFGF-23, iPTH, and B-SAP. Effects on bone biomarkers were similar in those with baseline serum total CO2 <24 mEq/L compared with those with total CO2 ≥24 mEq/L.

Conclusions
In this pilot trial of individuals with CKD and total CO2 20–28 mEq/L, sodium bicarbonate treatment increased serum klotho levels but did not affect other bone health markers over 28 weeks.

Clinical Trial registry name and registration number
ClinicalTrials.gov, NCT02521181.
Ameliorative Potential of Azadirachta indica and Gongronema latifolium on Plasmodium-induced Gonadotoxicity in Swiss Mice
Authors:   Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria., Peter Alice J. , Edagha Innocent A. ,   Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.,   Department of Human Anatomy, School of Medicine, Moi University, Eldoret, Kenya, Peter Aniekan I. ,   Department of Human Anatomy, School of Medicine, Moi University, Eldoret, Kenya, Udobang John A. ,   Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, University of Uyo, Uyo, Nigeria., Kia Balakumo E. ,   Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria., Asuquo Ikanna E. ,   Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria., Ataben Moses A. ,   Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria., Edem David O. ,   Department of Biochemistry, Faculty of Science, University of Uyo, Uyo, Nigeria.
Published: December 2023

Background: Polyherbal decoctions are frequently utilized by some Africans for anti-malaria treatment because they are readily accessible, and assumed low toxicity despite possible gonadotoxicities. We investigated ameliorative potential of anti-plasmodial plants Azadirachta indica (AI) and Gongronema latifolium (GL) on Plasmodium-induced gonadotoxities. Materials and methods: Adult male Swiss mice (n = 50) were allotted into 10 groups of (n = 5) animals. All groups were parasitized with 1 × 106P. berghei inoculum for three days except for groups 1 and 10; (normal control [NC]) and (non-parasitized mice administered Arthemeter-Lumefantrine [AL]). Group 2 was parasitized non-treated (PNT), groups 3 and 4 received low and high doses AI (86.60 and 259.81 mg), groups 5 and 6 received low and high doses GL (337.27 and 1011.80 mg), Groups 7, and 8 received low doses AI + GL (86.60 + 337.27 mg), and high doses AI + GL (259.81 + 1011.80 mg), while Group 9 received AL (8 mg), all odes via oral gavage per kg body weights, respectively. Rectal temperature, seminal/hormonal, testicular morphometry and histology assessments were evaluated using standard protocols. Results: Concurrent administration of AI and GL alleviated pyrexia and parasitemia in test groups, compared to NC and PNT groups. Testosterone concentrations were reduced in parasitized groups compared to NC, while sperm parameters significantly decreased (p < 0.05) in PNT and high AI + GL extract groups, but improved in combined low dose with testicular histoarchitecture. Conclusions: AI and GL concurrently administered at low doses mitigate P. berghei-induced gonadotoxicity better than as singly.	KEYWORDS: Anti-Malaria, Azadirachta Indica, Gongronema Latifolium, Gonadotoxicity, Histology.
Social and economic system of regional entrepreneurship as the object of strategizing
Authors: Korchagina I. V. , Pytchenko K. V. 
Published: December 2023

To realize the potential of regional entrepreneurship as a system of small and medium-sized enterprises (SMEs) of the region it is essential to develop a successful winning strategy oriented towards rapid exploitation of new opportunities. To this end, it is necessary to clarify the essence, boundaries, structure, and functions of the object of strategizing. The research is based on the general theory of strategy and methodology of strategizing, the theories of entrepreneurship, the systematic approach. The authors study approaches and theories that explain the essence, the functions and the structure of the system of regional entrepreneurship by applying systematization and content analysis methods. While analyzing the theories of entrepreneurship four components of the strategic mission of SMEs have been defined as follows: providing guarantees to partners, movement and productive use of factors of production, implementation of innovation, creation of gazelle companies (with the average annual increase in revenue or employment of more than 20% over 3 years). The study has shown that they are not fully implemented, and so the situation requires developing a new strategy or improving the old one. And the strategy of development of entrepreneurship in the region should contribute to the implementation of higher-level strategies (regional and sectoral). Moreover, the strategy should define the basic policies for strategizing the components of regional entrepreneurship – individual enterprises, clusters, different types of activities. The study offers a structural and logical scheme of relationship of the strategy of development of regional entrepreneurship (on the example of Kemerovo region – Kuzbass) with other strategic planning documents. Also, the authors justify the expediency of differentiation of strategic priorities of traditional and innovative entrepreneurship in the region. The analysis of theoretical foundations of exploring entrepreneurship as the object of strategizing has made it possible to clarify the basic components of its mission and justify the place of the corresponding strategy in the general system of strategic planning documents. Clarification of the boundaries and the content of the system under study ensures moving on to the strategic OTSW-analysis. The findings of the study can be used in justification of strategic decisions of entrepreneurs and regional authorities.
Gestión de la calidad en los Centros de Desarrollo Tecnológicos (CDT): revisión sistemática
Authors: Meneses-Mejía Oscar , De la Hoz-Toscano Milton , Pacheco-Molina Antonio 
Published: December 2023

El propósito de este artículo es presentar el analisis de los principales factores asociados a los procesos y procedimientos llevados a cabo en la gestión de la calidad y la operación integral de los CDT, teniendo en cuenta que la implementación de estándares y procesos de calidad permiten garantizar la fiabilidad y eficiencia en las actividades de investigación y desarrollo. Para lo anterior, se llevó a cabo un análisis documental de las normas de gestión de calidad y la guía técnica para el reconocimiento de actores establecida por Minciencias, en el que se analizaron las categorias de gestión de la calidad y Centros de Desarrollo Tecnológico. Como resultado de esto, se destacan algunas de las mejores prácticas en la gestión de la calidad que los centros de desarrollo tecnológicos implementan tales como: planeación estrategica, sistema de gestión de calidad documentado, formación y capacitación del personal en temas de calidad, y la participación activa en programas de certificación reconocidos. Finalmente, este artículo propone una metodología conceptual siguiendo el ciclo PHVA que podría ser implementado por los CDT para adoptar mejores prácticas en la gestión de la calidad, alcanzar buenos estándares de rendimiento y mantener su posición dentro del sistema de ciencia y tecnología.
Variables de condición física predictivas de sintomatología depresiva en estudiantes universitarios de Cali, Colombia
Authors: Carrillo Arango Hugo Alejandro , Atencio-Osorio Miguel Alejandro , Vidarte Claros José Armando 
Published: December 2023

Objetivo: Determinar las variables de condición física saludable predictoras de sintomatología depresiva en jóvenes universitarios.

Método: Este estudio presenta un diseño observacional descriptivo de corte transversal con una fase multivariada, que utilizó el cuestionario autoadministrado BECK (BDI-2) con el objetivo de determinar sintomatología depresiva, en una muestra de 344 estudiantes universitarios entre 18 y 39 años, matriculados en cuatro diferentes universidades de la ciudad de Santiago de Cali, Colombia. La condición física relacionada con la salud se valoró a partir de la batería Alpha Fit Adultos; con los análisis correlacionales se construyó un modelo de regresión logística binario que pudiera establecer cuáles variables de condición física se asocian a una sintomatología depresiva en este tipo de población.

Resultados: Correlaciones inversas y estadísticamente significativas fueron observadas entre el puntaje de depresión del inventario de Depresión de Beck-II, con los indicadores de condición física aeróbica r = -0,202, p=0,000; fuerza prensil media r = -0,113, p=0,036; salto alto r = -0,177, p=0,000; flexión de brazos r = -0,158, p=0,003; y test de figura en 8 r = -0,146, p=0,006). Universitarios con mayores niveles de sintomatología depresiva presentan un fenotipo de menor condición física, principalmente en el indicador de resistencia cardiorrespiratoria (β= -0,059; p<0,004 Exp (B) 0,942).

Conclusiones: Los resultados obtenidos en el presente estudio muestran que un fenotipo asociado a menor condición física cardiorrespiratoria se asocia con mayores niveles de sintomatología depresiva.
Abuso sexual en niños, niñas y adolescentes: factores de riesgo y sintomatología
Authors: Mebarak Chams Moises , Aragón – Barceló Jeremías , Álvarez – Alzate Ivanna , Oliveros Charris Jesús , Mejía Rodríguez Dania Liz 
Published: December 2023

Objetivo: Analizar avances en la literatura científica sobre factores de riesgo y sintomatología a corto y largo plazo del abuso sexual en niños, niñas y adolescentes.

Método: Mediante una revisión de artículos científicos en inglés y en español, se seleccionaron 27 investigaciones disponibles en APA PsycArticles, Dialnet, Springer y ScienceDirect, entre 2011 y 2020 con información cuantitativa o cualitativa sobre factores de riesgo y sintomatología del abuso sexual en niños, niñas y adolescentes.

Resultados: Se identifican factores de riesgo asociados a grupos etarios, principalmente entre 6-7 y 12-13 años, tipos de familias reconstituidas, así como a la presencia de cuidadores distintos a los padres. Entre los síntomas a corto plazo, se identifican cambios bruscos de comportamiento, dificultades en las relaciones interpersonales, angustia, miedo y culpa. Además, se registran lesiones físicas y alteraciones somáticas. A largo plazo se identifican síntomas asociados a estrés postraumático, conductas suicidas, trastornos alimenticios, dificultades de interacción social y en menor medida drogodependencia.

Conclusiones: Respecto a los factores de riesgo se visibiliza el uso de redes sociales como un referente a considerar en las dinámicas actuales. Sin embargo, la literatura enfatiza en seguir consolidando el análisis de estos factores y su articulación con acciones pertinentes para la prevención y atención oportuna del abuso. En cuanto a la sintomatología se evidencian avances en el análisis a corto plazo, pues no sólo se aborda lo físico y fisiológico sino también desde lo psicosocial. Similarmente, el análisis de la sintomatología a largo plazo se orienta principalmente a procesos psicosociales.
Russia-Czech Republic Relations on Television of the Czech Republic
Authors: Lapuk Ekaterina 
Published: December 2023

The Communist past is perceived negatively by modern Czechs and since Russia is the successor of the Soviet Union, a negative image can effect the coverage of Russian-Czech relations and the image of modern Russia in the Czech media. The study applied qualitative and quantitative content analysis to study the coverage of Russian-Czech relations by the leading television channels of the Czech Republic Česká televize 1 and Prima. The findings of the analysis of 1,195 video news illustrate that Russia plays a significant role on the international agenda of Česká televize 1 and Prima. The main feature of the coverage is a focus on the political and historical element of the Russian-Czech relations. 49 % of video news about Russian-Czech relations by Česká televize 1 were dedicated to politics, 28 % were about history, 8 % to sports and culture. A recurring theme in analyzed news about Russian-Czech relations is freedom’s theme. Česká televize 1 and Prima primarily focus on coverage of events inside the Czech Republic (at least 60 % of the analyzed news stories). Czech TV channels have a tendency to create heroic images of people criticizing authorities of the Russian Federation (B. Nemtsov, A. Politkovskaya after whom the Czechs named two city facilities in Prague). Another feature is the indirect creation of Russia’s image as a large militarized country, which played the role of an oppressor for the Czechs in the recent past.
Systematic Literature Review: Could Plasma Convalescent Prevent Death on COVID-19?
Authors: Widjaja Jordan Steven , Utami Prawesty Diah , Putri Jeanaya Hedya Alfara , Kusbijantoro Yemima Billyana 
Published: December 2023

The COVID-19 pandemic is still a global health problem, and the lack of effective and efficient treatment standards is one of the causes of the high morbidity and mortality rates. One approach often used in various cases of COVID-19 is convalescent plasma therapy. The administration of convalescent plasma is one of the treatment options that are often used in cases of COVID-19 with mild, moderate, severe, chronic, and critical symptoms. The article review aims to analyze how convalescent plasma transfusion in various cases of COVID-19 can prevent death and improve clinical outcomes. The PRISMA flowchart is applied to filter the literature that meets the inclusion criteria: published articles with experimental or observational research discussing the use of convalescent plasma in COVID-19 patients; published January 2020 - March 2021. We conducted article searches through PubMed, Google Scholar, and Science Direct. Assessment of the quality of the articles using the EPHPP form, and we chose ten articles. The results of the qualitative analysis prove that convalescent plasma administration in various COVID-19 cases significantly reduces viral load, clinical improvement and prevents death in mild, moderate, and severe COVID-19s, but for terminal or critical cases, it does not show significant results. The success rate of convalescent plasma therapy is determined by the high antibody titer in plasma donors, the distance between its administration and the onset of symptoms, and the patient's baseline condition before plasma administration. Based on these results, further research is needed to determine the standard dose and method of administration of convalescent plasma referring to the varied baseline conditions of patients.
Prevention of Postpartum Urinary Retention with Peppermint Oil Vapor
Authors: Aryanti Dewi , Triguna Yudi 
Published: December 2023

Urinary retention in the postpartum period (PPUR) is one of the health problems commonly handled using catheterization and antibiotic prophylaxis. This study aimed to look at the influence of peppermint oil on PPUR prevention. This quasi-experimental study with a control group design included 60 postpartum subjects (29 in the control group and 31 in the intervention group) with vaginal delivery (ages 17-50 years). The intervention group obtained treatment by giving 2 mL of peppermint oil, while the controlled group used mineral water in the closet before subjects sat on it for 5-10 minutes and voided. The bladder condition was further checked subjectively and manually by palpation before and after the exposure to peppermint oil (distention or no distention). The relationships between variables were analyzed using the Fisher Exact statistical test, obtaining no significant effect of peppermint oil administration variables on PPUR prevention (p = 0.495, CI 95%). PPUR is related to oxidative stress, tissue inflammation, and nerve impulse blocks. Peppermint oil is estimated to be one of the modalities in preventing health problems through antioxidant, anti-inflammatory, and antispasmodic effects. Further research is needed to validate the effect of peppermint oil on PPUR prevention. In addition, support of screening information on the condition of the bladder objectively using a bladder scanner is also needed to measure the post-void residual volume (PVRV). This study showed that peppermint oil on PPUR prevention has no significant effect and may require further investigation.
The Relationship of Psychological Well-being with a Cardiac Diet Self Efficacy in Acute Coronary Syndrome Patients
Authors: Fahmi Ismail , Suryaman Ade , Mashudi Mashudi , Ganefianty Amelia 
Published: December 2023

Acute Coronary Syndrome (ACS) is a cardiovascular disease that causes significant deaths in most countries. No study assessed the directly how this psychological well-being is related to Cardiac Diet Self-Efficacy (CDSE). This study aimed to identify the relationship between psychological well-being and cardiac diet self-efficacy in ACS patients after treatment. This cross-sectional study involved 150 patients at two hospitals in Jambi Province that treated heart disease, especially ACS. We used Cardiac Diet Self-Efficacy (CDSE) Scale and Psychological Well-Being questionnaire. The associations between psychological well-being a cardiac diet self-efficacy were confirmed by the Pearson Correlation test using SPSS 26.0. The correlation test showed a p-value of 0.018, indicating a relationship between psychological well-being and cardiac diet self-efficacy. Furthermore, the value of r obtained at 0.41 shows a reasonably strong relationship between psychological well-being and cardiac diet self-efficacy. Therefore, it is necessary to prepare for improving psychological well-being in ACS patients both from the discharge planning stage and post-hospital intervention so that ACS patients can have good cardiac diet self-efficacy after treatment.
Exploring the Antibacterial Potency of Citrus Fruit Peel Extracts Using Various Solvents
Authors: Prakash Shoba S  , Punitha A.  , Sona S. M.  , Thirunirai Selvi G.  , Venci Candida X  , Anitha C  
Published: December 2023

The study evaluates the inhibitory effect of different solvent-extracted citrus peel extracts (Citrus lemon, Citrus sinensis, Citrus maxima, Citrus reticulata and Citrus aurantiifolia) on the growth of various bacterial strains (Klebsiella. pneumonia, Staphylococcus. aureus, Pseudomonas aeruginosa, and Escherichia coli). Citrus lemon extract demonstrated the most significant inhibition with methanol and acetone showing the highest zones of inhibition. Citrus sinensis extract showed antibacterial activity, with the choice of solvent influencing the effectiveness. Methanol and acetone generally performed well. Citrus maxima extract demonstrated antibacterial activity, with methanol and butanol being effective solvents. Citrus reticulata extract's effectiveness varied depending on the solvent and bacterial strain tested. Ethanol and butanol were more effective solvents for inhibiting the growth of some bacteria, while acetone and methanol showed limited effectiveness. The Citrus aurentiifolia peel extract exhibited varying degrees of antibacterial activity against the tested bacteria. The effectiveness of the extract depended on the solvent used and the type of bacteria. For some bacteria, such as E. coli and S. aureus, the extract showed significant inhibitory effects, particularly when using Ethanol as the solvent. Further research and optimization may be necessary to enhance the antibacterial properties of Citrus aurentiifolia peel extract.
Impact of ingenious pre-treatments on performance indices and dimensional properties of kodo millet
Authors: Tatapudi Paul Pradeepa Roberts, Dr. Lt. S. Sharada  
Published: December 2023

The present study focussed on standardisation of suitable method for kodo dehulling and evaluated the outcome percentage of dehulled kodo millet. A combination of abrasive and centrifugal type of dehulling and hydrothermal treatment followed by centrifugal dehulling was applied on whole kodo millet. Only centrifugal dehulled millet was taken as control. Dehulling index, Coefficient of dehulling, degree of dehulling and overall dehulling efficiency was more compared to control samples. Principal axial dimensions, dimensional parameters such as sphericity, aspect ratio, geometric and arithmetic mean diameter was calculated and had significant difference between control and experimental samples.
Health Care Chatbot Assistant System
Authors: ADARSH H J  , Bhaskar Reddy P.V  , Suhasini S Hosamani  , Sharat S K  , Pavana Shivaram  
Published: December 2023

Rasa stack consists of many open source AI apparatuses solely utilized in plan to make a logical chatbot. It consists of incredible APIs embedded along the Rasa stack that incorporates Natural language understanding. It incorporates the sack of words calculation helping in streamlining portrayl utilized in measurable displaying and AI stages and furthermore trend setting innovation. The proposed framework is to make an option in contrast to this ordinary strategy for visiting a clinic and making a meeting with a specialist to get analysis. From the user queries chatbot will, predicts the infection and prescribes treatment along with necessary medicine. It like wise support the utilization of this RASA stage for the client specific format according to their prerequisites and furthermore elevates in building up the system for better efficiency.