bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic exocrine insufficiency after non-pancreatic upper gastrointestinal surgery: meta-analysis
Authors: Hall Lewis A , Powell-Brett Sarah , Halle-Smith James , Ward Liz , Wiggins Tom , Markar Sheraz R , Roberts Keith J 
Published: December 2023

Abstract

Background
Untreated pancreatic exocrine insufficiency (PEI) results in substantial patient harm. Upper gastrointestinal surgery (bariatric metabolic surgery and oesophagogastric resection) affects the delicate physiology of pancreatic exocrine function and may result in PEI. The aim of this study was to assimilate the literature on incidence, diagnosis, and management of PEI after bariatric metabolic surgery and oesophagogastric resection.

Methods
A systematic review of PubMed, MEDLINE, and Embase databases identified studies investigating PEI after non-pancreatic upper gastrointestinal surgery. Meta-analyses were undertaken for incidence of PEI and benefit of pancreatic enzyme replacement therapy.

Results
Among 1620 patients from 24 studies included in quantitative synthesis, 36.0% developed PEI. The incidence of PEI was 23.0 and 50.4% after bariatric metabolic surgery and oesophagogastric resection respectively. Notably, the incidence of PEI was 44% after biliopancreatic diversion with duodenal switch and 66.2% after total gastrectomy. The most common diagnostic test used was faecal elastase 1 (15 of 31 studies), with less than 200 µg/g being diagnostic of PEI. A total of 11 studies considered the management of pancreatic exocrine insufficiency, with 78.6% of patients responding positively to pancreatic enzyme replacement when it was prescribed.

Conclusion
PEI is common after non-pancreatic upper gastrointestinal surgery and patients may benefit from enzyme replacement therapy.
Broadening the clinical spectrum: molecular mechanisms and new phenotypes of ANO3-dystonia
Authors: Ousingsawat Jiraporn , Talbi Khaoula , Gómez-Martín Hilario , Koy Anne , Fernández-Jaén Alberto , Tekgül Hasan , Serdaroğlu Esra , Schreiber Rainer , Ortigoza-Escobar Juan Dario , Kunzelmann Karl 
Published: December 2023

Abstract
Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form phospholipid scramblases and ion channels. A large number of ANO3 variants were identified as the cause of craniocervical dystonia, but the underlying pathogenic mechanisms remain obscure. It was suggested that ANO3 variants may dysregulate intracellular Ca2+ signalling, as variants in other Ca2+ regulating proteins like hippocalcin were also identified as a cause of dystonia.
In this study, we conducted a comprehensive evaluation of the clinical, radiological and molecular characteristics of four individuals from four families who carried heterozygous variants in ANO3. The median age at follow-up was 6.6 years (ranging from 3.8 to 8.7 years). Three individuals presented with hypotonia and motor developmental delay. Two patients exhibited generalized progressive dystonia, while one patient presented with paroxysmal dystonia. Additionally, another patient exhibited early dyskinetic encephalopathy. One patient underwent bipallidal deep brain stimulation (DBS) and showed a mild but noteworthy response, while another patient is currently being considered for DBS treatment. Neuroimaging analysis of brain MRI studies did not reveal any specific abnormalities. The molecular spectrum included two novel ANO3 variants (V561L and S116L) and two previously reported ANO3 variants (A599D and S651N).
As anoctamins are suggested to affect intracellular Ca2+ signals, we compared Ca2+ signalling and activation of ion channels in cells expressing wild-type ANO3 and cells expressing anoctamin variants. Novel V561L and S116L variants were compared with previously reported A599D and S651N variants and with wild-type ANO3 expressed in fibroblasts isolated from patients or when overexpressed in HEK293 cells. We identified ANO3 as a Ca2+-activated phospholipid scramblase that also conducts ions. Impaired Ca2+ signalling and compromised activation of Ca2+-dependent K+ channels were detected in cells expressing ANO3 variants. In the brain striatal cells of affected patients, impaired activation of KCa3.1 channels due to compromised Ca2+ signals may lead to depolarized membrane voltage and neuronal hyperexcitability and may also lead to reduced cellular viability, as shown in the present study.
In conclusion, our study reveals the association between ANO3 variants and paroxysmal dystonia, representing the first reported link between these variants and this specific dystonic phenotype. We demonstrate that ANO3 functions as a Ca2+-activated phospholipid scramblase and ion channel; cells expressing ANO3 variants exhibit impaired Ca2+ signalling and compromised activation of Ca2+-dependent K+ channels. These findings provide a mechanism for the observed clinical manifestations and highlight the importance of ANO3 for neuronal excitability and cellular viability.
Differential cortical gray matter changes in early- and late-onset patients with amyotrophic lateral sclerosis
Authors: Ai Yuan , Li Fei , Hou Yanbing , Li Xiuli , Li Wenbin , Qin Kun , Suo Xueling , Lei Du , Shang Huifang , Gong Qiyong 
Published: December 2023

Abstract
Age at onset may be an important feature associated with distinct subtypes of amyotrophic lateral sclerosis (ALS). Little is known about the neuropathological mechanism of early-onset ALS (EO-ALS) and late-onset ALS (LO-ALS). Ninety ALS patients were divided into EO-ALS and LO-ALS group, and 128 healthy controls were matched into young controls(YCs) and old controls (OCs). A voxel-based morphometry approach was employed to investigate differences in gray matter volume (GMV). Significant age at onset-by-diagnosis interactions were found in the left parietal operculum, left precentral gyrus, bilateral postcentral gyrus, right occipital gyrus, and right orbitofrontal cortex. Post hoc analysis revealed a significant decrease in GMV in all affected regions of EO-ALS patients compared with YCs, with increased GMV in 5 of the 6 brain regions, except for the right orbitofrontal cortex, in LO-ALS patients compared with OCs. LO-ALS patients had a significantly increased GMV than EO-ALS patients after removing the aging effect. Correspondingly, GMV of the left postcentral gyrus correlated with disease severity in the 2 ALS groups. Our findings suggested that the pathological mechanisms in ALS patients with different ages at onset might differ. These findings provide unique insight into the clinical and biological heterogeneity of the 2 ALS subtypes.
Behavioral syndromes in paper wasps: Links between social and non-social personality in Polistes fuscatus
Authors: Jomaa Fatima W , Laub Emily C , Tibbetts Elizabeth A 
Published: December 2023

Abstract
Although much work has focused on non-social personality traits such as activity, exploration, and neophobia, there is a growing appreciation that social personality traits play an important role in group dynamics, disease transmission, and fitness and that social personality traits may be linked to non-social personality traits. These relationships are important because behavioral syndromes, defined here as correlated behavioral phenotypes, can constrain evolutionary responses. However, the strength and direction of relationships between social and non-social personality traits remain unclear. In this project, we examine social and non-social personality traits, and the relationships between them, in the paper wasp Polistes fuscatus. With a novel assay, we identify 5 personality traits, 2 non-social (exploration and activity), and 3 social (aggression, affiliation, and antennation) personality traits. We also find that social and non-social personality traits are phenotypically linked. We find a positive correlation between aggression and activity and a negative correlation between affiliation and activity. We also find a positive correlation between exploration and activity. Our work is an important step in understanding how phenotypic linkage between social and non-social behaviors may influence behavioral evolution. As a burgeoning model system for the study of genetic and neurobiological mechanisms of social behavior, Polistes fuscatus has the potential to add to this work by exploring the causes and consequences of individual behavioral variation.
Coronary artery disease in atrial fibrillation ablation: impact on arrhythmic outcomes
Authors: Cappello Ida Anna , Pannone Luigi , Della Rocca Domenico Giovanni , Sorgente Antonio , Del Monte Alvise , Mouram Sahar , Vetta Giampaolo , Kronenberger Rani , Ramak Robbert , Overeinder Ingrid , Bala Gezim , Almorad Alexandre , Ströker Erwin , Sieira Juan , La Meir Mark , Belsack Dries , Sarkozy Andrea , Brugada Pedro , Tanaka Kaoru , Chierchia Gian Battista , Gharaviri Ali , de Asmundis Carlo 
Published: December 2023

Abstract

Aims
Catheter ablation (CA) is an established treatment for atrial fibrillation (AF). A computed tomography (CT) may be performed before ablation to evaluate the anatomy of pulmonary veins. The aim of this study is to investigate the prevalence of patients with coronary artery disease (CAD) detected by cardiac CT scan pre-ablation and to evaluate the impact of CAD and revascularization on outcomes after AF ablation.

Methods and results
All consecutive patients with AF diagnosis, hospitalized at Universitair Ziekenhuis Brussel, Belgium, between 2015 and 2019, were prospectively screened for enrolment in the study. Inclusion criteria were (i) AF diagnosis, (ii) first procedure of AF ablation with cryoballoon CA, and (iii) contrast CT scan performed pre-ablation. A total of 576 consecutive patients were prospectively included and analysed in this study. At CT scan, 122 patients (21.2%) were diagnosed with CAD, of whom 41 patients (7.1%) with critical CAD. At survival analysis, critical CAD at CT scan was a predictor of atrial tachyarrhythmia (AT) recurrence during the follow-up, only in Cox univariate analysis [hazard ratio (HR) = 1.79] but was not an independent predictor in Cox multivariate analysis. At Cox multivariate analysis, independent predictors of AT recurrence were as follows: persistent AF (HR = 2.93) and left atrium volume index (HR = 1.04).

Conclusion
In patients undergoing CT scan before AF ablation, critical CAD was diagnosed in 7.1% of patients. Coronary artery disease and revascularization were not independent predictors of recurrence; thus, in this patient population, AF ablation should not be denied and can be performed together with CAD treatment.
Cannabigerolic Acid (CBGA) Inhibits the TRPM7 Ion Channel Through its Kinase Domain
Authors: Suzuki Sayuri , Wakano Clay , Monteilh-Zoller Mahealani K , Cullen Aaron J , Fleig Andrea , Penner Reinhold 
Published: December 2023

Abstract
Cannabinoids are a major class of compounds produced by the plant Cannabis sativa. Previous work has demonstrated that the main cannabinoids cannabidiol (CBD) and tetrahydrocannabinol (THC) can have some beneficial effects on pain, inflammation, epilepsy, and chemotherapy-induced nausea and vomiting. While CBD and THC represent the two major plant cannabinoids, some hemp varieties with enzymatic deficiencies produce mainly cannabigerolic acid (CBGA). We recently reported that CBGA has a potent inhibitory effect on both Store-Operated Calcium Entry (SOCE) via inhibition of Calcium Release-Activated Calcium (CRAC) channels as well as currents carried by the channel-kinase TRPM7. Importantly, CBGA prevented kidney damage and suppressed mRNA expression of inflammatory cytokines through inhibition of these mechanisms in an acute nephropathic mouse model. In the present study, we investigate the most common major and minor cannabinoids to determine their potential efficacy on TRPM7 channel function. We find that approximately half of the tested cannabinoids suppress TRPM7 currents to some degree, with CBGA having the strongest inhibitory effect on TRPM7. We determined that the CBGA-mediated inhibition of TRPM7 requires a functional kinase domain, is sensitized by both intracellular Mg⋅ATP and free Mg2+ and reduced by increases in intracellular Ca2+. Finally, we demonstrate that CBGA inhibits native TRPM7 channels in a B lymphocyte cell line. In conclusion, we demonstrate that CBGA is the most potent cannabinoid in suppressing TRPM7 activity and possesses therapeutic potential for diseases in which TRPM7 is known to play an important role such as cancer, stroke, and kidney disease.
Carotenoid retention during post-harvest storage of Capsicum annuum: the role of the fruit surface structure
Authors: Holden Alexandra C , Cohen Hagai , Berry Harriet M , Rickett Daniel V , Aharoni Asaph , Fraser Paul D 
Published: December 2023

Abstract
In this study, a chilli pepper (Capsicum annuum) panel for post-harvest carotenoid retention was studied to elucidate underlying mechanisms associated with this commercial trait of interest. Following drying and storage, some lines within the panel had an increase in carotenoids approaching 50% compared with the initial content at the fresh fruit stage. Other lines displayed a 25% loss of carotenoids. The quantitative determination of carotenoid pigments with concurrent cellular analysis indicated that in most cases, pepper fruit with thicker (up to 4-fold) lipid exocarp layers and smooth surfaces exhibit improved carotenoid retention properties. Total cutin monomer content increased in medium/high carotenoid retention fruits and subepidermal cutin deposits were responsible for the difference in exocarp thickness. Cutin biosynthesis and cuticle precursor transport genes were differentially expressed between medium/high and low carotenoid retention genotypes, and this supports the hypothesis that the fruit cuticle can contribute to carotenoid retention. Enzymatic degradation of the cuticle and cell wall suggests that in Capsicum the carotenoids (capsanthin and its esters) are embedded in the lipidic exocarp layer. This was not the case in tomato. Collectively, the data suggest that the fruit cuticle could provide an exploitable resource for the enhancement of fruit quality.
Comparison of Laboratory Diffraction Contrast Tomography and Electron Backscatter Diffraction Results: Application to Naturally Occurring Chromites
Authors: Chen Xiao , Godel Belinda , Verrall Michael 
Published: December 2023

Abstract
Understanding how minerals are spatially distributed within natural materials and their textures is indispensable to understanding the fundamental processes of how these materials form and how they will behave from a mining engineering perspective. In the past few years, laboratory diffraction contrast tomography (LabDCT) has emerged as a nondestructive technique for 3D mapping of crystallographic orientations in polycrystalline samples. In this study, we demonstrate the application of LabDCT on both chromite sand and a complex chromitite sample from the Merensky Reef (Bushveld Complex, South Africa). Both samples were scanned using LabDCT and Electron Backscatter Diffraction (EBSD), and the obtained results were rigorously evaluated using a comprehensive set of qualitative and quantitative characterization techniques. The quality of LabDCT results was accessed by using the “completeness” value, while the inaccuracies were thoroughly discussed, along with proposed potential solutions. The results indicate that the grain orientations obtained from LabDCT are comparable to that of 2D EBSD but have the advantage of collecting true 3D size, shape, and textural information. This study highlights the significant contribution of LabDCT in the understanding of complex rock materials from an earth science perspective, particularly in characterizing mineral texture and crystallography in 3D.
UOCS – XI. Study of blue straggler stars in open cluster NGC 7142 using UVIT/AstroSat
Authors: Panthi Anju , Vaidya Kaushar , Vernekar Nagaraj , Subramaniam Annapurni , Jadhav Vikrant , Agarwal Manan 
Published: December 2023

ABSTRACT
We present a study of blue straggler stars (BSSs) of open cluster NGC 7142 using AstroSat/UVIT data and other archival data. Using a machine-learning-based algorithm, ML-MOC, on Gaia DR3 data, we find 546 sources as cluster members. Based on the location on the Gaia colour–magnitude diagram, we identify 10 BSS candidates, also detected in UVIT/F148W filter. We study the variable nature of BSSs by constructing their light curves using the Transiting Exoplanet Survey Satellite data. Two BSSs reported as eclipsing binaries in Gaia DR3 are confirmed to be eclipsing binaries based on our analysis and also show the presence of hot companions as per the multiwavelength spectral energy distributions (SEDs). The physical parameters of the hot companions of these two BSSs derived by fitting binary models to their light curves and those derived from the SEDs are found to be in good agreement. Additionally, five more BSSs in the cluster shows UV excess, four of which are likely to have a hot companion based on SEDs. The hot companions with the estimated temperatures ∼14 000–28 000 K, radii ∼0.01–0.05 R⊙, and luminosities ∼0.03–0.1 L⊙ are inferred to be extremely low-mass (&lt;0.2 M⊙), low-mass (0.2–0.4 M⊙), normal-mass (0.4–0.6 M⊙), and high-mass (&gt;0.6 M⊙) white dwarfs (WDs). For the first time in an open cluster, we find the entire range of masses in WDs found as hot companions of BSSs. These masses imply that the Case-A/Case-B mass transfer and merger are responsible for the formation of at least 60 per cent of the BSSs of this cluster.
Geometry of the LMC based on multiphase analysis of multiwavelength Cepheid light curves using OGLE-IV and Gaia DR3 data
Authors: Bhuyan Gautam , Deb Sukanta , Kanbur Shashi M , Bellinger Earl P , Deka Mami , Bhardwaj Anupam 
Published: December 2023

ABSTRACT
The period–luminosity (PL) relation of Cepheids in the Large Magellanic Cloud (LMC) plays a pivotal role in extragalactic distance measurement and the determination of the Hubble constant (H0). In this work, we probe the geometry of the LMC through a detailed study of multiphase PL relations of these Cepheids, leveraging data from the OGLE-IV and Gaia DR3 data bases. We analyse the light curves of a combined sample of ∼3300 fundamental (FU) and first overtone (FO) mode classical Cepheids. We obtain multiphase data with 50 phase points over a complete pulsation cycle from the OGLE (V, I) and Gaia (G, GBP, GRP) photometric bands. We determine the distance modulus and reddening values of individual Cepheids by fitting a simultaneous reddening law to the apparent distance modulus values. We calculate the LMC viewing angle parameters: the inclination angle (i) and position angle of line of nodes (θlon) by fitting a plane of the form z = f(x, y) to the three-dimensional distribution of Cepheids in Cartesian coordinates $(x, y, z)$. The values of LMC viewing angles from multiphase PL relations are found to be: i = 22.°87 ± 0.°43 (stat.) ± 0.°53 (syst.), θlon = 154.°76 ± 1.°16 (stat.) ± 1.°01 (syst.), respectively. The use of multiphase PL relations in multiple bands results in lower uncertainties for the LMC viewing angle parameters as compared to those derived from the mean-light PL relations. This shows that the use of multiphase PL relations with multiwavelength photometry significantly improves the precision of these measurements, allowing better constraints on the morphology and the structure of the LMC.
The ALMaQUEST Survey XI: a strong but non-linear relationship between star formation and dynamical equilibrium pressure
Authors: Ellison Sara L , Pan Hsi-An , Bluck Asa F L , Krumholz Mark R , Lin Lihwai , Hunt Leslie , Corbelli Edvige , Thorp Mallory D , Barrera-Ballesteros Jorge , Sánchez Sebastian F , Scudder Jillian M , Quai Salvatore 
Published: December 2023

ABSTRACT
We present the extended ALMA MaNGA QUEnching and STar formation survey (ALMaQUEST), a combination of the original 46 ALMaQUEST galaxies plus new ALMA observations for a further 20 interacting galaxies. Three well-studied scaling relations are fit to the 19 999 star-forming spaxels in the extended sample, namely the resolved Schmidt–Kennicutt relation, the resolved star-forming main-sequence and the resolved molecular gas main sequence. We additionally investigate the relationship between the dynamical equilibrium pressure (PDE) and star formation rate surface density (ΣSFR), which we refer to as the resolved PDE (rPDE) relation. Contrary to previous studies that have focussed on normal star-forming galaxies and found an approximately linear rPDE relation, the presence of more vigourously star-forming galaxies in the extended ALMaQUEST sample reveals a marked turnover in the relation at high pressures. Although the scatter around the linear fit to the rPDE relation is similar to the other three relations, a random forest analysis, which can extract non-linear dependences, finds that PDEis unambiguously more important than either $\Sigma _{\rm H_2}$ or Σ⋆ for predicting ΣSFR. We compare the observed rPDE relation to the prediction of the pressure-regulated feedback-modulated (PRFM) model of star formation, finding that galaxies residing on the global SFMS do indeed closely follow the rPDE relation predicted by the PRFM theory. However, galaxies above and below the global SFMS show significant deviations from the model. Galaxies with high SFR are instead consistent with models that include other contributions to turbulence in addition to the local star formation feedback.
Magnetothermal evolution in the cores of adolescent neutron stars: The Grad–Shafranov equilibrium is never reached in the ‘strong-coupling’ regime
Authors: Moraga Nicolás A , Castillo Francisco , Reisenegger Andreas , Valdivia Juan A , Gusakov Mikhail E 
Published: December 2023

ABSTRACT
At the high temperatures inside recently formed neutron stars ($T\gtrsim 5\times 10^{8}\, \text{K}$), the particles in their cores are in the ‘strong-coupling’ regime, in which collisional forces make them behave as a single, stably stratified, and thus non-barotropic fluid. In this regime, axially symmetric hydromagnetic quasi-equilibrium states are possible, which are only constrained to have a vanishing azimuthal Lorentz force. In these states, the particle species deviate from chemical (β) equilibrium, which tends to be restored by β decays (Urca reactions), inducing fluid motions that change the magnetic field configuration. If the stars remained hot for a sufficiently long time, this evolution would eventually lead to a chemical equilibrium state, in which the fluid is barotropic and the magnetic field, if axially symmetric, satisfies the non-linear Grad–Shafranov equation. Here, we present a numerical scheme that decouples the magnetic and thermal evolution, enabling to efficiently perform, for the first time, long-term magnetothermal simulations in this regime for different magnetic field strengths and geometries. Our results demonstrate that, even for magnetar-strength fields $\gtrsim 10^{16} \, \mathrm{G}$, the feedback from the magnetic evolution on the thermal evolution is negligible. Thus, as the core passively cools, the Urca reactions quickly become inefficient at restoring chemical equilibrium, so the magnetic field evolves very little, and the Grad–Shafranov state is not attained. Therefore, any substantial evolution of the core magnetic field must occur later, in the ‘weak-coupling’ regime ($T\lesssim 5\times 10^8 \, \mathrm{K}$), when Urca reactions are frozen and ambipolar diffusion becomes relevant.