bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and effectiveness of a two-tiered intervention involving training and a new consultation model for patients with palliative care needs in primary care: A before-after study
Authors: Seiça Cardoso Carlos , Prazeres Filipe , Oliveiros Bárbara , Nunes Cátia , Simões Pedro , Aires Carolina , Rita Patrícia , Penetra Joana , Lopes Paulo , Alcobia Sara , Baptista Sara , Venâncio Carla , Gomes Barbara 
Published: January 2024

Background: Evidence suggests that involving General Practitioners in the care of patients with palliative care needs may improve patient outcomes. Aim: To evaluate whether a two-tiered intervention involving training in palliative care and a new consultation model in primary care for patients with palliative care needs is feasible and could reduce patients’ symptom burden. Design: Before-after study including an internal pilot. Setting/participants: Nine general practitioners working in a health region in Portugal and 53 patients with palliative care needs from their patient lists were recruited. General Practitioners received training in palliative care and used a new primary palliative care consultation model, with medical consultations every 3 weeks for 12 weeks. The primary outcome was physical symptom burden, self-reported using the Integrated Palliative care Outcome Scale (IPOS) patient version (min.0–max.1000). Secondary outcomes included emotional symptoms (min.0–max.400) and communication/practical issues (min.0–max.300). Results: Of the 35/53 patients completed the 12-week intervention (mean age 72.53 years, SD = 13.45; 54.7% female). All had advanced disease: one third had cancer ( n = 13), one third had congestive heart failure ( n = 12); others had chronic kidney disease and chronic obstructive pulmonary disease. After the 12 weeks of intervention, there was a reduction in physical symptom burden [mean difference from baseline of 71.42 (95%CI 37.01–105.85) with a medium-large effect size (0.71], and in emotional symptom burden [mean difference 42.86 (95%CI 16.14–69.58), with a medium effect size (0.55)]. No difference was found for communication/practical issues. Conclusions: Our intervention can be effective in reducing patients’ physical and emotional symptoms. Trial registration: ClinicalTrials.gov ID – NCT05244590. Registration: 14th February 2022.
The diagnostic value of ultrasonography in evaluation of the intraneural vascular anomalies of peripheral nerves
Authors: Chen Wen , Wang Yeting , Qi Hengtao , Wang Tiezheng 
Published: January 2024

Background The imaging diagnosis of intraneural vascular anomalies of peripheral nerves mostly depended on magnetic resonance imaging (MRI), whereas high-frequency ultrasonography evaluation of intraneural vascular anomalies has been seldom done. Purpose To evaluate the diagnostic value of ultrasonography in the diagnosis of intraneural vascular anomalies of peripheral nerves. Material and Methods A total of 69 consecutive patients seen at Shandong Provincial Hospital Affiliated to Shandong First Medical University between February 2013 and June 2022, each with a clinical suspicion of intraneural vascular anomaly, were included. The ultrasonographic images of intraneural vascular anomalies of peripheral nerves were analyzed and the ultrasonographic features were summarized. These data were compared with MRI, which served as the gold standard for the diagnosis of intraneural vascular anomalies. The kappa statistic was adopted to determine the level of agreement. The sensitivity, specificity, positive and negative predictive values, accuracy, and Youden index of high-frequency ultrasonography as a diagnostic tool were assessed. Results Ultrasonography findings were positive in 20 of 69 patients with a clinical suspicion of intraneural vascular anomaly. The diagnosis was confirmed by MRI in 21 patients. There was one false-positive result and two false-negative results by ultrasonography. The κ value was 0.896. The sensitivity, specificity, positive and negative predictive values, accuracy, and Youden index of ultrasonography were 90.5%, 97.9%, 95%, 95.9%, 95.7%, and 0.884, respectively. Conclusion Ultrasonography could be an accurate, reliable, and convenient imaging tool for the diagnosis of intraneural vascular anomalies of peripheral nerves.
Does realizing strengths, insight, and behavioral practice through a psychological intervention promote personality change? An intensive longitudinal study
Authors: Allemand Mathias , Olaru Gabriel , Stieger Mirjam , Flückiger Christoph 
Published: January 2024

The mechanisms of change underlying the effectiveness of personality change interventions are largely unclear. In this study, we used data from a three-month digital intervention with an intensive longitudinal design to test whether a greater realization of general change factors is partly responsible for personality change. Participants ( N = 679, 53.0% female; age: M = 25.3 years, SD = 7.1) seeking to increase either Emotional Stability, Conscientiousness, or Extraversion provided self-ratings on their weekly personality states and the three generic change factors of strengths, insights, and behavioral practice. We found a single-factor structure of change factors within and between individuals. Results showed within-person increases in Emotional Stability, Extraversion, and Conscientiousness states as well as increases in change factors across the intervention. Changes in personality states were coupled with changes in generic change factors. Finally, the results provide initial support for the hypothesis that the realization of general change factors is partly responsible for the effects of the intervention. Within-person increases in the change factors were associated with subsequent increases in Extraversion and Emotional Stability states during the following week. The present findings highlight the need to better understand how and why people change in personality as a result of interventions.
Improving partner notification for sexually transmitted infections: Interviews with key informants in Aotearoa New Zealand
Authors: Murray Catriona , Rose Sally B 
Published: January 2024

Background Partner notification is a vital part of sexually transmitted infection (STI) control but evidence suggests that its practice in Aotearoa New Zealand (NZ) is inconsistent. This study sought to explore barriers to partner notification for STIs, identify areas for improvement and draw on lessons learnt from Covid-19. Methods Semi-structured interviews with key informants working in primary care, sexual health, public health, management, and research were undertaken between December 2021 and March 2022. Interviews were audiorecorded, transcribed, coded, and analysed using thematic analysis. Results The overarching theme was that partner notification for STIs needs to be improved, and must be a more acceptable experience for providers, cases and their contacts. Four themes described how this could be achieved: (i) destigmatise and increase understanding of STIs, (ii) ensure engagement with services is easy and affirming, (iii) prioritise and resource evidence-based services and (iv) develop tools to optimise partner notification. Conclusions Sexually transmitted infection partner notification in NZ needs prioritisation, resourcing and innovation. The inadequate resourcing of STI management in NZ contrasts with the well-funded response to Covid-19. Without a well-resourced action plan, NZ’s high rates of STIs will persist and continue to inequitably impact Māori, Pacific, gay and bisexual men and young people.
Complement C4d as a biomarker for systemic lupus erythematosus and lupus nephritis
Authors: Qin Sihao , Wang Xueyao , Wang Jiahui , Wu Hao 
Published: January 2024

Background: Increasing studies in the last decade have led to the widespread understanding that C4d, a split product of complement component 4 (C4), is a potential biomarker for systemic lupus erythematosus (SLE) and lupus nephritis (LN). Purpose: The aim of this review is to summarize the highlights of studies investigating the use of C4d as a biomarker for diagnosing and monitoring SLE and LN patients. Data collection: we searched PubMed/Medline and Wanfang databases using the terms “C4d and systemic lupus erythematosus”, “C4d and lupus nephritis”, and “Complement C4d”. Results: The deposition of C4d on circulating blood cells has been shown in several clinical studies to be a potential diagnostic marker that can be used to monitor patients with SLE. In addition, C4d deposits on circulating blood cells may be a helpful diagnostic marker for LN, one of the most severe complications of SLE. Meanwhile, studies utilizing renal biopsy specimens have indicated that C4d deposition in the renal peritubular capillaries of LN patients may predict more severe LN or a worse patient prognosis. Generally, a high plasma C4d level and a high plasma C4d/C4 ratio may also be promising indicators that can be used to monitor patients with SLE and LN. Conclusions: C4d detection may be a novel strategy for further clinical prediction and therapy.
Healthcare Students’ Anxiety, Cognitive Load, and Trait-mindfulness during Interprofessional obstetric Simulation Training
Authors: Takhdat Kamal , Rebahi Houssam , Eddabbah Mohamed , El Fadely Abdelmonim , Lamtali Saloua , El Adib Ahmed Rhassane 
Published: January 2024

Background Simulation anxiety can hinder healthcare students' learning. Trait-mindfulness may help reduce learners' anxiety and improve their cognitive load during simulation training. However, the relationship between healthcare students' anxiety, trait mindfulness, and cognitive load has not been studied together during undergraduate interprofessional obstetric emergency simulation training. Methods This observational correlational research examined the relationship between healthcare students' anxiety, trait-mindfulness, and cognitive load. Furthermore, it examined whether healthcare students' trait-mindfulness can moderate the effect of anxiety on cognitive load during undergraduate interprofessional obstetric emergency simulation training. Forty-six undergraduate medical and nursing students were enrolled in this study. Each participant (in a team of 3 to 4) completed one postpartum hemorrhage scenario. The French versions of the State-Trait Anxiety Inventory (STAI-Y; Gauthier & Bouchard, 1993), the Mindfulness Attention Awareness Scale (Germann et al., 2009), and Paas’s cognitive load scale (Paas, 1992) were used to measure anxiety, trait-mindfulness, and cognitive load, respectively. Results The study results show a positive correlation between healthcare students’ state-anxiety and cognitive load. Additionally, healthcare students’ mindfulness moderated the effect of state-anxiety on cognitive load during simulation training. Discussion As a personality trait, healthcare students’ mindfulness is associated with reduced simulation anxiety and improved cognitive load during obstetric emergency simulation training. Besides the learning tasks and simulation environment characteristics, simulation instructors should consider healthcare students’ anxiety and mindfulness to optimize their cognitive load during simulation training. Conclusion The study demonstrated that healthcare students’ trait mindfulness mitigates the magnitude of simulation anxiety on cognitive load during emergency simulation training. It suggests further examining healthcare students’ personality traits to detect potential interactions of their traits with the simulation learning process.
Feline ventral abdominal wall angiosarcoma: haemangiosarcoma or lymphangiosarcoma? Clinical and pathological characteristics in nine cases
Authors: Bellamy Edward , Larsen Moberg Hanne , Suárez-Bonnet Alejandro , Palma Stefano Di , Murgia Daniela , Pittaway Rachel , Verganti Sara 
Published: January 2024

Objectives Angiosarcomas are rare malignant mesenchymal neoplasms of endothelial cell origin with a predilection to the ventral abdominal wall in cats. Larger case series describing this entity are lacking. Methods Two referral centre laboratory databases were searched for angiosarcoma of the ventral abdominal wall. Nine cases with a histological diagnosis were included. Immunohistochemistry (factor VIII and PROX-1 antibodies) was used to phenotype them as haemangiosarcoma or lymphangiosarcoma. Results All cats presented with a ventral abdominal mass, five of which were producing a serosanguinous discharge. Eight underwent tumour staging and pulmonary metastases were suspected in one cat (but not histologically confirmed). With histopathology alone, a diagnosis of angiosarcoma and lymphangiosarcoma was made in four and five cases, respectively. After immunohistochemistry, five cases had a haemangiosarcoma phenotype and four had a lymphangiosarcoma phenotype, including two cases of lymphangiosarcoma that were reclassified as hemangiosarcoma. Eight cats received treatment (either surgery with or without adjuvant therapies or medical management alone). Six cats were euthanased due to local disease progression. The median survival time for haemangiosarcoma was 166 days (range 137–381), and for lymphangiosarcoma it was 197 days (range 67–208). Two cats with haemangiosarcoma remained alive for a follow-up period of 329 and 580 days, respectively. Conclusions and relevance Feline ventral abdominal angiosarcomas are rare locally aggressive neoplasms. While histology often provides a diagnosis of angiosarcoma, immunohistochemistry is ultimately required to differentiate between haemangiosarcoma and lymphangiosarcoma phenotypes. Further studies are required to evaluate whether the different phenotypes have an impact on treatment response and outcome.
Vertical stiffness limit of 400 km/h high-speed railway simple-supported bridge considering excitation randomness
Authors: Chen Xuli , Xiang Huoyue , Zhu Jin , Li Yongle 
Published: January 2024

Vertical stiffness of the bridge is of paramount importance in guaranteeing optimal driving performance for high-speed railway (HSR) trains. Initially, the Auto Regression and Moving Average model with eXogenous input (ARMAX) model is employed as the surrogate model for the train-bridge (TB) coupling system. Then, the framework for analyzing vertical bridge stiffness is proposed employing the surrogate model, and the relationship between the train response affected by excitation randomness and the vertical stiffness indicators of the bridge is established. Finally, the influence of various factors such as train speed, train type, car body mass, and bridge span on stiffness limit of 400 km/h HSR simple-supported bridge (SSB) is examined. The results indicate that the surrogate model offers a notable advantage in computational efficiency, while maintaining a satisfactory accuracy in predicting the train response. With higher train speeds, lighter car body masses, and longer spans, the demand for stricter bridge stiffness limits becomes more pronounced. Based on the driving performance of the train types analyzed, the recommended stiffness limit is proposed for the prestressed concrete simply supported beam (SSB) bridges used in HSR, with a span length of less than 40 m and operating at a speed of 400 km/h.
Designing technology to support greater participation of people living with dementia in daily and meaningful activities
Authors: Wilson Michael , Doyle Julie , Turner Jonathan , Nugent Ciaran , O’Sullivan Dympna 
Published: January 2024

BackgroundPeople living with dementia should be at the center of decision-making regarding their plans and goals for daily living and meaningful activities that help promote health and mental well-being. The human–computer interaction community has recently begun to recognize the need to design technologies where the person living with dementia is an active rather than a passive user of technology in the management of their care.MethodsData collection comprised semi-structured interviews and focus groups held with dyads of people with early-stage dementia (n = 5) and their informal carers (n = 4), as well as health professionals (n = 5). This article discusses findings from the thematic analysis of this qualitative data.ResultsAnalysis resulted in the construction of three main themes: (1) maintaining a sense of purpose and identity, (2) learning helplessness and (3) shared decision-making and collaboration. Within each of the three main themes, related sub-themes were also constructed.DiscussionThere is a need to design technologies for persons living with dementia/carer dyads that can support collaborative care planning and engagement in meaningful activities while also balancing persons living with dementia empowerment and active engagement in self-management with carer support.
Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
Authors: Ahsan Nuzhat , Shariq Mohd , Surolia Avadhesha , Raj Reshmi , Khan Mohammad Firoz , Kumar Pramod 
Published: January 2024

AbstractTRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains. These proteins are efficient regulators of autophagy, apoptosis, and innate immune responses and confer immunity against viruses and bacteria. TRIMs function as receptors or scaffold proteins that target substrates for autophagy-mediated degradation. Most TRIMs interact with the BECN1-ULK1 complex to form TRIMosomes, thereby efficiently targeting substrates to autophagosomes. They regulate the functions of ATG proteins through physical interactions or ubiquitination. TRIMs affect the lipidation of MAP1LC3B1 to form MAP1LC3B2, which is a prerequisite for phagophore and autophagosome formation. In addition, they regulate MTOR kinase and TFEB, thereby regulating the expression of ATG genes. TRIM proteins are efficient regulators of apoptosis and are crucial for regulating cell proliferation and tumor formation. Many TRIM proteins regulate intrinsic and extrinsic apoptosis via the cell surface receptors TGFBR2, TNFRSF1A, and FAS. Mitochondria modulate the anti- and proapoptotic functions of BCL2, BAX, BAK1, and CYCS. These proteins use a multipronged approach to regulate the intrinsic and extrinsic apoptotic pathways, culminating in coordinated activation or inhibition of the initiator and executor CASPs. Furthermore, TRIMs can have a dual effect in determining cell fate and are therefore crucial for cellular homeostasis. In this review, we discuss mechanistic insights into the role of TRIM proteins in regulating autophagy and apoptosis, which can be used to better understand cellular physiology. These findings can be used to develop therapeutic interventions to prevent or treat multiple genetic and infectious diseases.Graphical Abstract
Kinase inhibitor pulldown assay (KiP) for clinical proteomics
Authors: Saltzman Alexander B. , Chan Doug W. , Holt Matthew V. , Wang Junkai , Jaehnig Eric J. , Anurag Meenakshi , Singh Purba , Malovannaya Anna , Kim Beom-Jun , Ellis Matthew J. 
Published: January 2024

AbstractProtein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein kinase ERBB2 is critical for therapeutic decisions. While immunohistochemistry (IHC) is the current clinical diagnostic approach, it is only semiquantitative. Mass spectrometry-based proteomics offers quantitative assays that, unlike IHC, can be used to accurately evaluate hundreds of kinases simultaneously. The enrichment of less abundant kinase targets for quantification, along with depletion of interfering proteins, improves sensitivity and thus promotes more effective downstream analyses. Multiple kinase inhibitors were therefore deployed as a capture matrix for kinase inhibitor pulldown (KiP) assays designed to profile the human protein kinome as broadly as possible. Optimized assays were initially evaluated in 16 patient derived xenograft models (PDX) where KiP identified multiple differentially expressed and biologically relevant kinases. From these analyses, an optimized single-shot parallel reaction monitoring (PRM) method was developed to improve quantitative fidelity. The PRM KiP approach was then reapplied to low quantities of proteins typical of yields from core needle biopsies of human cancers. The initial prototype targeting 100 kinases recapitulated intrinsic subtyping of PDX models obtained from comprehensive proteomic and transcriptomic profiling. Luminal and HER2 enriched OCT-frozen patient biopsies subsequently analyzed through KiP-PRM also clustered by subtype. Finally, stable isotope labeled peptide standards were developed to define a prototype clinical method. Data are available via ProteomeXchange with identifiers PXD044655 and PXD046169.
Adherence to commercial food thickener in patients with oropharyngeal dysphagia
Authors: Peñalva-Arigita Amaya , Lecha Maria , Sansano Anna , Prats Rosa , Vásquez Aida , Bascuñana Helena , Vila Lluis 
Published: January 2024

Abstract
Background
Oropharyngeal dysphagia (OD), a common symptom in the elderly, uses commercial thickener (CT) as part of its treatment. This is often accompanied of dislike and poor compliance.

Aim
Describe adherence to CT and possible differences according to dwelling location in an area of influence of approximately 400.0000 inhabitants.

Methods
Cohort prospective observational study. Randomized patients from Nutrition and Dietetic (NDU)-database (4 calls-interviews/year). Variables: Age, diagnostic, gender, dwelling/location: Home (H) / Nursing Home (NH), viscosity (nectar, honey, pudding), days with CT. Adherence measured with a questionnaire, considering implementation of treatment by combining CT use and consumption data, categorised in three groups good, moderate and poor. Change in patterns (improvement, maintenance, worsening) and non-adherence reasons.

Results
One hundred sixty-eight patients recruited with indicated viscosity: Nectar 39.7%, honey 29.3% and pudding 30.8%. Average age of 82.6 ± 11.1 years; 57.8% women (46.4% at H vs. 67% at NH, p < 0.01). Dwelling/location: 80 (47.6%) live at H and 88 (52.4%) at NH. Days with CT prior study were 509 ± 475.28. Implementation found in first call: good in 50%, moderate in 20.2% and poor in 29.8%. At first call, adherence parameters were more favourable in NH compared to H. However these parameters were reversed during the study period as there was an improvement at H vs. NH. Also in terms of change in patterns a significant improvement of implementation was found in patients living at H, 31.1% vs. those living at NH, 15.7%, p < 0.05. CT persistence throughout study was 89.7%.

Conclusions
Low adherence to CT found in our community. Telephone follow-up resulted in improved adherence, especially in the H population. Our data provides valuable insights into the variability and changes in CT adherence among patients with OD. Adherence is complex and subject to many factors and dwelling/location is one of them. This study reveals the need to approach CT treatment for OD differently in NH.