bluuebunny/crossref_metadata_2025_split huggingface dataset:
Визначення вмісту металів (Cu, Fe, Zn) у фармацевтичній сировині, лікарських засобах і в дієтичній добавці методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою
Authors: Брицун В. М. , Нємчінова І. В. , Тарасенко Н. Л. , Савіна Н. О. , Останіна Н. В. 
Published: November 2023

Мета дослідження – визначення вмісту металів міді – (Cu), заліза (Fe), цинку (Zn) – методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою у фармацевтичній сировині, лікарських засобах і дієтичній добавці, які були передані для випробовувань у Державну науково-дослідну лабораторію контролю якості лікарських засобів.
Визначення концентрацій Cu, Fe, Zn проведено методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою на оптико-емісійному спектрометрі Agilent 5800 ICP-OES. Вимірювання вмісту металів проведено шляхом порівняння емісії досліджуваних розчинів з емісією стандартних розчинів на довжинах хвиль: Cu 327,395 нм, Fe 238,204 нм, Zn 213,857 нм. Як зразки для дослідження використовували фармацевтичну сировину (аскорбінову кислоту, аскорбат натрію, сульфіт натрію, вугілля активоване та інші), лікарські засоби антибіотичної й антидіабетичної дії, упаковочний матеріал для лікарських форм, дієтичну добавку.
Усього було перевірено на вміст металів 37 зразків: Cu – 19, Fe – 4, Zn – 32. Концентрації, які більші, ніж межа виявлення приладу, зафіксовані для Сu – 89,5 % випробуваних зразків, для Fe і Zn – 100 % випробуваних зразків.
Встановлено, що вміст Cu і Fe у фармацевтичній сировині, лікарських засобах, упаковці фармацевтичної продукції відповідає вимогам нормативних документів у 100 % зразків. Уміст Zn відповідає вимогам нормативних документів у 96,9 % зразків (у дієтичній добавці встановлено перевищення вмісту Zn в 2,1 разу). Дієтична добавка за вмістом Zn не відповідає вимогам НД.
Причини відповідності вмісту металів у фармацевтичній продукції – жорсткі вимоги, які прописані в фармакопеях, й обов’язковість їхнього виконання. Дієтичні добавки не відносяться до лікарських засобів чи фармацевтичної сировини, тому виробники не обтяжують себе дотриманням точного складу своєї продукції. Тому в перспективі слід підвищувати обов’язковість контролю за дієтичними добавками на предмет відповідності реального вмісту тих чи інших речовин заявленій рецептурі, подібно до того, як це є з продукцією фармацевтичної промисловості.
Pengalaman LSL Dalam Pemanfataan Pelayanan Voluntary Counseling And Testing (VCT)
Authors: Nugraha Nandang Jamiat , Rismalinda Ajeng Sri , Hidayat Yayat 
Published: November 2023

Penelitian ini dilatarbelakangi oleh pengalaman peneliti secara langsung mendapatkan informasi dari hasil wawancara bahwa sikap LSL terhadap adanya pelayanan program VCT ini berbeda-beda, sebagian menyatakan kesenangannya terhadap VCT dan sebagian memperlihatkan sikap ketidakpeduliannya terhadap program VCT, hal ini disebabkan oleh beberapa alsan, diantaranya ketakutan akan identitasnya sebagai LSL diketahui banyak orang, ketakutan akan hasil diagnosis yang di dapat, dan rasa malu untuk melakukan pemeriksaan. Penelitian ini bertujuan untuk mendapatkan gambaran tentang pengalaman LSL dalam pemanfaatan VCT di Kota Bandung. penelitian ini dilaksanakan mulai Mei sampai Juli 2018 dengan menggunakan metode penelitian kualitatif dan menggunakan pendekatan fenomenologi. Data didapat dengan teknik wawancara mendalam terhadap 5 partisipan laki-laki, usia 22 sampai 37 tahun. Hasil penelitian didapatkan 3 tema yaitu faktor pendukung pemanfaatan VCT, faktor penghambat pemanfaatan VCT dan harapan partisipan untuk VCT ke depan. Berdasarkan penelitian ini dapat disimpulkan bahwa LSL mengalami hambatan dalam pemanfaatan VCT di karenakan rendahnya persepsi terhadap layanan VCT serta ketersediaan waktu pelayanan dimana waktu pelaksanaan berada pada jam aktif kerja. Sebagai harapan dalam penelitian ini tidak ada lagi petugas kesehatan yang mendiskriminasi di setiap tempat layanan VCT serta diperlukan upaya-upaya dan strategi kembali untuk meningkatkan sosialisasi kepada komunitas untuk pelayanan program VCT.
A proximal sensing cart and custom cooling box for improved hyperspectral sensing in a desert environment
Authors: Thompson Alison L. , Thorp Kelly R. , Conley Matthew M. , Pauli Duke 
Published: November 2023

BackgroundAdvancements in field spectrometry have the potential to increase understanding of crop growth and development in response to hot and dry environments. However, as with any instrument used for scientific advancement, it is important to continue developing and optimizing data collection protocols to promote efficiency, safety, and data quality. The goal of this study was to develop a novel data collection method, involving a proximal sensing cart with onboard cooling equipment, to improve deployments of a field spectroradiometer in a hot and dry environment. Advantages and disadvantages of the new method were compared with the traditional backpack approach and other approaches reported in literature.ResultsThe novel method prevented the spectroradiometer from overheating and nearly eliminated the need to halt data collection for battery changes. It also enabled data collection from a significantly larger field area and from more field plots as compared to the traditional backpack method. Use of a custom cooling box to stabilize operating temperatures for the field spectroradiometer also improved stability of white panel data both within and among collections despite outside air temperatures in excess of 30°C.ConclusionsAs compared to traditional data collection approaches for measuring spectral reflectance of field crops in a hot and dry environment, use of a proximal sensing cart with a customized equipment cooling box improved spectroradiometer performance, increased practicality of equipment transport, and reduced operator safety concerns.
Study of mechanical effects of lumbar disc arthroplasty on facet joints at the index level/adjacent levels by using a validated finite element analysis
Authors: Zot François , Ben-Brahim Estelle , Severyns Mathieu , Ledoux Yann , Mesnard Michel , Caillé Laëtitia , Swennen Cécile , Teyssédou Simon , Moufid Abdollah-Yassine , Germaneau Arnaud , Vendeuvre Tanguy 
Published: November 2023

Introduction: Lumbar disc arthroplasty is a surgical procedure designed to treat degenerative disc disease by replacing the affected disc with a mobile prosthesis. Several types of implants fall under the term total disc replacement, such as ball-and-socket, mobile core or elastic prostheses. Some studies have shown that facet arthritis can develop after arthroplasty, without much precision on the mechanical impact of the different implant technologies on the facet joints. This study aims to create validated patient-specific finite element models of the intact and post-arthroplasty lumbar spine in order to compare the mechanical response of ball-and-socket and elastic prostheses.Methods: Intact models were developed from CT-scans of human lumbar spine specimens (L4-S1), and arthroplasty models were obtained by replacing the L4-L5 disc with total disc replacement implants. Pure moments were applied to reproduce physiological loadings of flexion/extension, lateral bending and axial rotation.Results: Models with ball-and-socket prosthesis showed increased values in both range of motion and pressure at the index level and lower values at the adjacent level. The mechanical behaviour of the elastic prosthesis and intact models were comparable. The dissipated friction energy in the facet joints followed a similar trend.Conclusion: Although both implants responded to the total disc replacement designation, the mechanical effects in terms of range of motion and facet joint loads varied significantly not only between prostheses but also between specimens. This confirms the interest that patient-specific surgical planning using finite element analysis could have in helping surgeons to choose the appropriate implant for each patient.
Estimation of radon and natural radioactive emissions from two of the most widely used construction materials in Egypt
Authors: Abd-Elghany Amr A. , Diab Hassan M. , Yousef Ahmed M. M. , Saleh Hosam M. 
Published: November 2023

As the risk of lung cancer increases with increasing radon exposure, the preferred measure of this risk is the long-term average radon level. The assessment of the radiation risk in workplaces in Egypt is constrained by the lack of experimental data about the measurements of natural radioactivity emitted from some common building materials and radon concentration within the buildings. The natural radioactive Ra-226, Th-232 series, and K-40 were computed in (Bq/kg) by a pure hyperactive germanium detector based on gamma spectroscopy to determine the potential health risk from exposure to gamma radiation induced by commonly used construction materials in Egypt such as ceramics and granite materials. The spatial variations of radon concentrations within two buildings, in over 50 rooms, made from two different types of building materials were surveyed using nuclear detectors (CR-39) to assess radon concentration for two successive 6 months. To analyze the relationship through radon concentration and floor levels for the use of ceramic tile improved construction materials, tier average ratios respecting the ground floor as a reference-grade consideration were also computed. All the findings of this research were analyzed and contrasted with the traditional ceramic construction material and it was clear that the “ceramics tile construction building” is a hygienic workplace which may be attributed to the use of improved construction materials and radiation shielding.
Size-correlated polymorphisms in phyllotaxis-like periodic and symmetric tentacle arrangements in hydrozoan Coryne uchidai
Authors: Sarper Safiye E. , Kitazawa Miho S. , Nakanishi Tamami , Fujimoto Koichi 
Published: November 2023

Introduction: Periodic organ arrangements occur during growth and development and are widespread in animals and plants. In bilaterian animals, repetitive organs can be interpreted as being periodically arranged along the two-dimensional space and defined by two body axes; on the other hand, in radially symmetrical animals and plants, organs are arranged in the three-dimensional space around the body axis and around plant stems, respectively. The principles of periodic organ arrangement have primarily been investigated in bilaterians; however, studies on this phenomenon in radially symmetrical animals are scarce.Methods: In the present study, we combined live imaging, quantitative analysis, and mathematical modeling to elucidate periodic organ arrangement in a radially symmetrical animal, Coryne uchidai (Cnidaria, Hydrozoa).Results: The polyps of C. uchidai simultaneously formed multiple tentacles to establish a regularly angled, ring-like arrangement with radial symmetry. Multiple rings periodically appeared throughout the body and mostly maintained symmetry. Furthermore, we observed polymorphisms in symmetry type, including tri-, tetra-, and pentaradial symmetries, as individual variations. Notably, the types of radial symmetry were positively correlated with polyp diameter, with a larger diameter in pentaradial polyps than in tetra- and triradial ones. Our mathematical model suggested the selection of size-correlated radial symmetry based on the activation-inhibition and positional information from the mouth of tentacle initiation.Discussion: Our established quantification methods and mathematical model for tentacle arrangements are applicable to other radially symmetrical animals, and will reveal the widespread association between size-correlated symmetry and periodic arrangement principles.
Effect of intermediate-term firewood smoke air pollution on cardiometabolic risk factors and inflammatory markers
Authors: Lanas Fernando , Saavedra Nicolás , Saavedra Kathleen , Hevia Montserrat , Seron Pamela , Salazar Luis A. 
Published: November 2023

BackgroundTemuco is a city in Southern Chile with elevated levels of air pollution (AP), mainly due to using wood as combustion throughout the cold season. The study aimed to assess the differences in cardiometabolic risk factors, estimated cardiovascular risk, and blood level of inflammatory markers between high AP (HAP) and low AP (LAP) periods.MethodsA prospective panel study was conducted between January to September 2018. Air pollution was assessed by PM2.5 concentration. Ninety individuals from the general population were included in the study. Measurements were performed in the HAP and LAP, including medical history and lifestyle, physical activity assessment, physical exam, and fasting blood samples for glucose, lipids, and circulatory inflammatory mediators.ResultsIn the high air pollution period, systolic blood pressure was 3 mmHg higher (p = 0.05). HDL-cholesterol was 14.2 mg/dl lower (p &lt; 0.001), Framingham risk score increased from 14.5 to 18.0 (p &lt; 0.001), and highly significant lower levels of interleukins, MCP1, MMP1, MMP2, sICAM, and svCAM were observed.ConclusionsHAP was associated with increased cardiometabolic risk factors and estimated cardiovascular risk. However, a lower level of circulating acute inflammatory molecules was observed. Inflammatory molecules blood levels were not associated with changes in cardiometabolic risk factors.
Serum VEGF as a predictive marker of glycemic control and diabetic nephropathy in Chinese older adults with type 2 diabetes mellitus
Authors: Jiang Yanyan , Li Jianhua , Zhang Juan , Chen Sufang 
Published: November 2023

ObjectivesRecent researches have demonstrated good correlation between vascular endothelial growth factor (VEGF) and diabetic nephropathy (DN); however, this relationship seems less clear-cut when VEGF was measured in blood samples. We tended to explore the possible association between serum VEGF and glycemic control and diabetic nephropathy severity in Chinese older adults with type 2 diabetes mellitus (T2DM).Materials and methodsThis study retrospectively enrolled 595 older T2DM adults at random. Participants were clinically grouped across the urine albumin-to-creatinine ratio (UACR) and the HbA1c tertiles by genders. Linear regressions were performed for the correlation of VEGF with HbA1c and UACR and binary logistic regressions for the odds of DN after adjusting for confounders. The receiver operating characteristic (ROC) curves were conducted for the predictive value of VEGF for DN.ResultsBoth males and females with DN exhibited higher VEGF levels than non-DN (P &lt; 0.001). Furthermore, a positive correlation of VEGF with UACR and HbA1c was presented regardless of adjusting confounding factors (P &lt; 0.001). Serum VEGF level and fasting plasma glucose (FPG) were independent risk factors of DN in older adults of both genders (P &lt; 0.05), while the risk prediction of DN by HbA1c only reflected in female patients (P &lt; 0.05). The ROC curve of VEGF for DN had the area under curve (AUC) of 0.819 for males and 0.793 for females, indicating the clinical value of serum VEGF as a predictive biomarker.ConclusionsSerum VEGF was strongly associated with UACR and HbA1c in both genders, and could be regarded as a predictive biomarker for glycemic control and diabetic nephropathy in older adults with T2DM.
Causal relationship between linoleic acid and type 2 diabetes and glycemic traits: a bidirectional Mendelian randomization study
Authors: Liang Hao , Mu Hai-Bo , Zhang Fei-Hu , Li Wen-Qiang , Li Guo-Chen , Li Wen-Dong , Liang Min , He Zeng-Lin 
Published: November 2023

ObjectiveTo investigate the causal relationships between linoleic acid and type 2 diabetes, and between linoleic acid and glycemic traits in European populations.MethodsThis study employed a two-sample Mendelian randomization approach to infer causality between linoleic acid and type 2 diabetes, as well as between linoleic acid and glycemic traits, leveraging genetic variations. Data were sourced from genome-wide association study summary datasets. Random-effects inverse-variance weighted, weighted median, and MR-Egger methods were used for the two-sample Mendelian randomization analyses. Results were presented as odds ratios with a 95% confidence interval. Multiple sensitivity analyses were conducted to assess result robustness.ResultsMR findings indicated a correlation between linoleic acid levels and the risk of type 2 diabetes, fasting blood glucose, and glycated hemoglobin (HbA1c), but not with fasting insulin. Specifically: type 2 diabetes (OR: 0.811, 95% CI: 0.688–0.956, P=0.013&lt;0.05),fasting blood glucose (β_IVW): -0.056, 95% CI: (-0.091,-0.021), P=0.002&lt; 0.0125), glycated hemoglobin (β_IVW: -0.032, 95% CI: (-0.048,-0.015), P=0.0002&lt; 0.0125) and Fasting insulin (β_IVW: -0.024, 95% CI: (-0.056,-0.008), P=0.136 &gt;0.05).Reverse MR analyses showed a correlation between type 2 diabetes and reduced levels of linoleic acid (β_IVW: -0.033, 95% CI: (-0.059,-0.006), P=0.014&lt;0.05). Multiple sensitivity analyses also detected study heterogeneity but found no evidence of horizontal pleiotropy.ConclusionHigh levels linoleic acid can reduce the risk of type 2 diabetes, fasting blood glucose, and glycated hemoglobin, but has no significant relation with fasting insulin. Type 2 diabetes can lower linoleic acid levels; however, no significant causal relationship was observed between the three glycemic traits and reduced levels of linoleic acid.
The role of bone modifying agents for secondary osteoporosis prevention and pain control in post-menopausal osteopenic breast cancer patients undergoing adjuvant aromatase inhibitors
Authors: Galvano Antonio , Gristina Valerio , Scaturro Dalila , Bazan Russo Tancredi Didier , Tomasello Sofia , Vitagliani Fabio , Carità Federica , La Mantia Maria , Fulfaro Fabio , Bazan Viviana , Mauro Giulia Letizia , Russo Antonio 
Published: November 2023

IntroductionHormonal therapy (HT) blocks the hormone-mediated growth signal dramatically reducing estrogenic levels with aromatase inhibitors (AIs) becoming a crucial component of the treatment mainstay in patients with early breast cancer (BC). Postmenopausal BC patients receiving HT present with a significant risk of secondary osteoporosis with AIs further reducing estrogen levels and ultimately leading to an accelerated rate of bone resorption and thus decreased bone mineral density (BMD). This was an observational retrospective clinical study that consecutively enrolled early BC patients with osteopenia to compare the impact of alendronate versus denosumab on secondary osteoporosis prevention and pain control.MethodsWe identified two groups of patients treated with denosumab 60 mg by subcutaneous injection once every six months or alendronate 70 mg orally once a week. All the patients underwent a baseline physiatric evaluation (T0) and underwent a follow-up visit after 18 months (T1) together with femoral and vertebral Dual-Energy X-ray Absorptiometry (DEXA) exam evaluating T-Score marks. From September 2015 to December 2019 a total of 50 early (stage I-III) BC patients were considered eligible and consecutively enrolled in our study if they met pre-specified inclusion criteria. ResultsIn the entire observed population, the addition of treatment with alendronate or denosumab led to a significant T-score improvement at the lumbar spine level (-1.92 vs -1.52, p=0.03), with a comparable contribution from alendronate (-1.60 vs -1.45, p=0.07) and denosumab (-2.26 vs -1.58, p=0.07). Regarding the femoral region, neither alendronate (-0.98 vs -1.07, p=0.23) nor denosumab (-1.39 vs -1.34, p=0.81) were able to produce any statistically relevant effect. However, concerning pain control, BMAs had a significant impact on reducing NRS scoresin the general population (T1 3.94 vs. baseline 4.32, p=0.007), with a likelyspecific contribution from alendronate (T1 3.52 vs. baseline 3.88, p=0.004) compared to denosumab (T1 4.36 vs baseline 4.76, p=0.12), without any differences in analgesic therapy assumption over time (p=0.93).DiscussionBoth alendronate and denosumab significantly contributed to preventing secondary osteoporosis in early BC patients with low BMD undergoing AIs, mostly at the lumbar spine level. Moreover, alendronate seemed to significantly impact pain control in such patients further supporting alendronate as a cost-effective option in this frail setting, although BMAs particularities should be carefully considered on an individual basis according to specific clinical contexts.
Assessment of different classification systems for predicting the risk of superior laryngeal nerve injury during thyroid surgery: a prospective cohort study
Authors: Li Changlin , Zhang Jiao , Dionigi Gianlorenzo , Sun Hui 
Published: November 2023

BackgroundA multitude of anatomical variations have been noted in the external branch of the superior laryngeal nerve (EBSLN). In this study, intraoperative neuromonitoring (IONM) was used to assess the potential value of the different classical EBSLN classifications for predicting the risk of EBSLN injury.MethodsIn total, 136 patients with thyroid nodules were included in this prospective cohort study, covering 242 nerves at risk (NAR). The EBSLN was identified by observing the cricothyroid muscle twitch and/or typical electromyography (EMG) biphasic waveform. The EBSLNs were classified by Cernea classification, Kierner classification, and Friedman classification, respectively. The EMG parameters and outcomes of vocal acoustic assessment were recorded.ResultsThe distribution of Cernea, Kiernea, and Friedman subtypes were, respectively, Cernea 1 (40.9%), Cernea 2A (45.5%), Cernea 2B (10.7%), Kierner 1 (40.9%), Kierner 2 (45.5%), Kierner 3 (10.7%), Kierner 4 (2.9%) and Friedman 1 (15.7%), Friedman 2 (33.9%), Friedman 3 (50.4%). The amplitudes of EBSLN decreased significantly after superior thyroid pole operation, respectively, in Cernea 2A (193.7 vs. 226.6μV, P=0.019), Cernea 2B (185.8 vs. 221.3μV, P=0.039), Kierner 2 (193.7vs. 226.6μV, P=0.019), Kierner 3 (185.8 vs. 221.3μV, P=0.039), Kierner 4 (126.8vs. 226.0μV, P=0.015) and Friedman type 2 (184.8 vs. 221.6μV, P=0.030). There were significant differences in Fmax and Frange for Cernea 2A (P=0.001, P=0.001), 2B (P=0.001, P=0.038), Kierner 2 (P=0.001), Kierner 3 (P=0.001, P=0.038), and Friedman 2 (P=0.004, P=0.014). In the predictive efficacy of EBSLN injury, the Friedman classification showed higher accuracy (69.8% vs. 44.3% vs. 45.0%), sensitivity (19.5% vs. 11.0% vs. 14.0%), and specificity (95.6% vs. 89.9% vs. 89.9%) than the Cernea and Kierner classifications. However, the false negative rate of Friedman classification was significantly higher than other subtypes (19.5% vs. 11.0% vs. 14.0%).ConclusionCernea 2A and 2B; Kierner 2, 3, and 4; and Friedman 2 were defined as the high-risk subtypes of EBSLN. The risk prediction ability of the Friedman classification was found to be superior compared to other classifications.