bluuebunny/crossref_metadata_2025_split huggingface dataset:
The chromosome-level genome of Chinese praying mantis Tenodera sinensis (Mantodea: Mantidae) reveals its biology as a predator
Authors: Yuan Ruizhong , Zheng Boying , Li Zekai , Ma Xingzhou , Shu Xiaohan , Qu Qiuyu , Ye Xiqian , Li Sheng , Tang Pu , Chen Xuexin 
Published: October 2023

Abstract

Background
The Chinese praying mantis, Tenodera sinensis (Saussure), is a carnivorous insect that preys on a variety of arthropods and small vertebrates, including pest species. Several studies have been conducted to understand its behavior and physiology. However, there is limited knowledge about the genetic information underlying its genome evolution, digestive demands, and predatory behaviors.

Findings
Here we have assembled the chromosome-level genome of T. sinensis, representing the first sequenced genome of the family Mantidae, with a genome size of 2.54 Gb and scaffold N50 of 174.78 Mb. Our analyses revealed that 98.6% of BUSCO genes are present, resulting in a well-annotated assembly compared to other insect genomes, containing 25,022 genes. The reconstructed phylogenetic analysis showed the expected topology placing the praying mantis in an appropriate position. Analysis of transposon elements suggested the Gypsy/Dirs family, which belongs to long terminal repeat (LTR) transposons, may be a key factor resulting in the larger genome size. The genome shows expansions in several digestion and detoxification associated gene families, including trypsin and glycosyl hydrolase (GH) genes, ATP-binding cassette (ABC) transporter, and carboxylesterase (CarE), reflecting the possible genomic basis of digestive demands. Furthermore, we have found 1 ultraviolet-sensitive opsin and 2 long-wavelength-sensitive (LWS) opsins, emphasizing the core role of LWS opsins in regulating predatory behaviors.

Conclusions
The high-quality genome assembly of the praying mantis provides a valuable repository for studying the evolutionary patterns of the mantis genomes and the gene expression profiles of insect predators.
Radioelement abundances and heat production in the Paleoarchaean and early Neoarchaean granitoids of the Singhbhum Craton, eastern India: Thermal and geodynamic implications
Authors: Ray Labani , Dey Sukanta , Chopra Nishu 
Published: October 2023

SUMMARY
Distributions of long-lived radioelements (Th, U and K) in the upper crust play a vital role in lithospheric thermal modelling and understanding of underlying geodynamic processes. In the present study, we report abundances of Th, U, K and radiogenic heat production (A) in Paleoarchaean and early Neoarchaean granitoids from the Singhbhum Craton, located in the eastern part of the Indian shield, for the first time in a systematic way, using laboratory gamma-ray spectrometric set-up. We have studied 204 samples consisting of Paleoarchaean gneiss, three phases of Paleoarchaean Singhbhum Granite and early Neoarchaean granitoid. Th, U, K and A in the Paleoarchaean Singhbhum Granite are found to be marginally higher (10.8 ppm, 1.4 ppm, 2.4 per cent and 1.3 μWm−3) than the Paleoarchaean gneiss (9.6 ppm, 1.7 ppm, 1.8 per cent and 1.3 μWm−3). In comparison, such values are much higher in the early Neoarchaean granitoid (31.1 ppm, 4.2 ppm, 3.9 per cent, and 3.6 μWm−3). The surface heat production (1.36 μWm−3) of this craton is comparatively low compared to most cratons worldwide. In addition, it has the lowest average crustal heat production (0.42 µWm−3), due to which it will contribute little to the observed surface heat flow. Moreover, Th is a dominant component in heat production, followed by U and K in these granitoids. Spatially, radioelement ratios Th/U and K/U show similar trends as the radioelements, indicating systematic depletion of Th and U, compared to K. The study also indicates that the spatially separated coeval granitoids are formed from different magma sources in the heterogeneous crust that prevailed during the Archaeans. The lower radioelement abundances in the Paleoarchaean granitoids mostly resulted from the partial melting of mafic sources, whereas higher radioelement abundances in the early Neoarchaean granitoids resulted from the partial melting of the felsic source.
The burden of very early dropout in infertility care: a nationwide population-based cohort study
Authors: Ben Messaoud Khaoula , Bouyer Jean , Guibert Juliette , de La Rochebrochard Elise 
Published: October 2023

Abstract

STUDY QUESTION
What is the frequency and the associated factors of very early dropout following unsuccessful clomiphene citrate (CC)/gonadotropin treatment in the context of full coverage of treatment cost.

SUMMARY ANSWER
Despite free treatment, almost one in four women had a very early dropout following unsuccessful CC/gonadotropin treatment, with patients below the poverty line being more likely to drop out early.

WHAT IS KNOWN ALREADY
Success of infertility care is tarnished by very high dropout rates. Infertility care dropout has been considered as resulting principally from financial barriers because of the high cost of treatment. Nearly all previous work addressed dropout following IVF/ICSI. Factors associated with dropout following CC/gonadotropins may be different and also need to be investigated.

STUDY DESIGN, SIZE, DURATION
Nationwide population-based cohort study.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Using the French national health insurance and hospital databases, we included in the cohort 27 416 women aged 18–49 years unsuccessfully treated with CC/gonadotropins in 2017. The main outcome was very early dropout, defined as discontinuation of all infertility treatment after unsuccessful treatment for 1–3 months. Very early treatment dropout was analysed by multivariate logistic regression.

MAIN RESULTS AND THE ROLE OF CHANCE
Among women unsuccessfully treated with CC/gonadotropins, 22% dropped out of infertility care within 3 months. In multivariate analysis, higher early dropout following unsuccessful CC/gonadotropin treatment was associated with older and younger ages (≥35 and &lt;25 years), being below the poverty line, being treated with CC prescribed by a general practitioner and lack of infertility tests or monitoring.

LIMITATIONS, REASONS FOR CAUTION
This study is based on health administrative data that do not include reasons for dropout and record only a limited amount of information. It is thus not possible to analyse the reason for early dropout.

WIDER IMPLICATIONS OF THE FINDINGS
Despite full coverage of all infertility treatment, women under the poverty line have a higher risk of very early dropout following unsuccessful CC/gonadotropin treatment. Better understanding is needed of the non-financial barriers and difficulties faced by these patients. To address disparities in infertility treatment, practitioner training could be reinforced to adapt to patients from different social and cultural backgrounds.

STUDY FUNDING/COMPETING INTEREST(S)
This work was supported by the ANR StimHo project, grant ANR-17-CE36-0011-01 from the French Agence Nationale de la Recherche. The authors have no conflict of interest to declare.

TRIAL REGISTRATION NUMBER
N/A.
Strategies for smoothing power fluctuations in lithium-ion battery–supercapacitor energy storage systems
Authors: Liu Zenglei , Lu An 
Published: October 2023

Abstract
Onshore wind power has received attention from governments, including China and Europe, as a renewable energy generation technology. Still, it is highly influenced by weather factors and often requires energy storage systems to smooth its power. The hybrid energy storage system (HESS), comprising a lithium-ion battery and a supercapacitor (SC), fully uses the advantages of both the lithium-ion battery and SC with high energy and high power density. The contribution of this paper is to give a control strategy for internal power coordination and smoothing power fluctuation in HESS. For internal power coordination, when the state of charge (SOC) of a lithium-ion battery and SC are not in the normal range simultaneously, the lithium-ion battery power limit must be adjusted to regulate their SOC. In contrast, for smoothing power fluctuation, a low-pass filter is used to reduce the charge/discharge depth of the lithium-ion battery and maintain the SOC of SC. The trigonometric factor is used to optimize the particle swarm optimization (PSO) to obtain a better power distribution value. The proposed strategy is optimized using onshore wind power generation and load 1-day power variation, and the results achieve the desired goal with superior application.
Prevalence of antibiotic prescribing in COVID-19 patients in China and other low- and middle-income countries during the pandemic (December 2019—March 2021): a systematic review and meta-analysis
Authors: Cong Wenjuan , Cheng Hung-Yuan , Stuart Beth , Liu Binjuan , Tang Yunyi , Wang Yi , AIhusein Nour , Wang Hexing , Manchundiya Amit , Lambert Helen 
Published: October 2023

Abstract

Objectives
Low- and middle-income countries (LMICs) are particularly vulnerable to the threat of antimicrobial resistance (AMR). Use of antibiotics to treat COVID-19 patients during the pandemic may have contributed to increasing the AMR burden, but systematic evidence is lacking.

Methods
We searched Web of Science, EMBASE, PubMed, China National Knowledge Infrastructure (CNKI) and VIP databases from 1 December 2019 to 31 March 2021. Interventional and observation studies across all settings that reported antibiotic use in at least 10 COVID-19 patients were included. We restricted publications to English and Chinese languages. Screening and data extraction were undertaken by at least two independent reviewers. Results were synthesized using random-effects meta-analyses. Subgroup analyses and meta-regression were used to explore heterogeneities. This review was registered with PROSPERO (CRD42021288291).

Results
We included 284 studies involving 210 611 participants in 19 countries. The antibiotic prescribing rates (APRs) in COVID-19 inpatients were 71.7% (95% CI 66.7%–76.5%) in China and 86.5% (77.1%–93.9%) in other LMICs, respectively. APR was lower in mild/moderate cases in China [66.9% (57.9%–75.4%) compared with 91.8% (71.4%–100%) in other LMICs]. High APRs were found among pregnant women and the elderly in China. Disparities in APRs of other patient groups were identified. In studies reporting bacterial infections, the prevalence was 17.3% (10.0%–25.9%) in China and 24.9% (0.1%–68.8%) in other LMICs. Several antibiotics on the WHO ‘Watch’ and ‘Reserve’ lists were prescribed frequently in LMICs.

Conclusions
Inappropriate antibiotic use and high prevalence of antibiotic prescribing were found in COVID-19 inpatients in many LMICs.
Prediction of short-acting beta-agonist usage in patients with asthma using temporal-convolutional neural networks
Authors: Hirons Nicholas , Allen Angier , Matsuyoshi Noah , Su Jason , Kaye Leanne , Barrett Meredith A 
Published: October 2023

Abstract

Objective
Changes in short-acting beta-agonist (SABA) use are an important signal of asthma control and risk of asthma exacerbations. Inhaler sensors passively capture SABA use and may provide longitudinal data to identify at-riskpatients. We evaluate the performance of several ML models in predicting daily SABA use for participants with asthma and determine relevant features for predictive accuracy.

Methods
Participants with self-reported asthma enrolled in a digital health platform (Propeller Health, WI), which included a smartphone application and inhaler sensors that collected the date and time of SABA use. Linear regression, random forests, and temporal convolutional networks (TCN) were applied to predict expected SABA puffs/person/day from SABA usage and environmental triggers. The models were compared with a simple baseline model using explained variance (R2), as well as using average precision (AP) and area under the receiving operator characteristic curve (ROC AUC) for predicting days with ≥1–10 puffs.

Results
Data included 1.2 million days of data from 13 202 participants. A TCN outperformed other models in predicting puff count (R2 = 0.562) and day-over-day change in puff count (R2 = 0.344). The TCN predicted days with ≥10 puffs with an ROC AUC score of 0.952 and an AP of 0.762 for predicting a day with ≥1 puffs. SABA use over the preceding 7 days had the highest feature importance, with a smaller but meaningful contribution from air pollutant features.

Conclusion
Predicted SABA use may serve as a valuable forward-looking signal to inform early clinical intervention and self-management. Further validation with known exacerbation events is needed.
Understanding the Drivers of Cost and Length of Stay in a Cohort of 21,875 Patients with Severe Burn
Authors: Hauc Sacha C , Stögner Viola Antonia , Ihnat Jacqueline M , Hosseini Helia , Huelsboemer Lioba , Kauke-Navarro Martin , Rivera Jean C , Williams Mica , Glahn Joshua Z , Savetamal Alisa , Pomahac Bohdan 
Published: October 2023

AbstractBurn management has significantly advanced in the past 75 years, resulting in improved mortality rates. However, there are still over one million burn victims in the United States each year, with over 3,000 burn-related deaths annually. The impacts of individual patient, hospital, and regional demographics on length of stay (LOS) and total cost have yet to be fully explored in a large nationally representative cohort. Thus, this study aimed to examine various hospital and patient characteristics using a sample of over 20,000 patients. Inpatient data from the National Inpatient Sample from 2008 to 2015 were analyzed, and only patients with an ICD-9 code for second- or third-degree burns were included. In addition, a major operating room procedure must have been indicated on the discharge summary for patients to be included in the final dataset, ensuring that only severe burns requiring complex care were analyzed. Analysis of covariance models was used to evaluate the impact of various patient, hospital, and regional variables on both LOS and cost. The study found that skin grafts and fasciotomy significantly increased the cost of hospitalization. Having burns on the face, neck, and trunk significantly increased costs for patients with second-degree burns, while burns on the trunk resulted in the longest LOS for patients with third-degree burns. Infections in the hospital and additional procedures, such as flaps and skin grafts, also led to longer stays. The study also found that the prevalence of postoperative complications, such as electrolyte imbalance, was high among patients with burn surgery.
Loss of the vitamin D receptor triggers senescence in chronic myeloid leukemia via DDIT4-mediated DNA damage
Authors: Xu Yan , Qi Wentao , Zheng Chengzu , Li Yuan , Lu Zhiyuan , Guan Jianmin , Lu Chunhua , Zhao Baobing 
Published: October 2023

Abstract
Chronic myeloid leukemia (CML) is a hematopoietic malignancy driven by the fusion gene BCR::ABL1. Drug resistance to tyrosine kinase inhibitors (TKIs), due to BCR::ABL1 mutations and residual leukemia stem cells (LSCs), remains a major challenge in CML treatment. Here, we revealed the requirement of the vitamin D receptor (VDR) in the progression of CML. VDR was upregulated by BCR::ABL1 and highly expressed in CML cells. Interestingly, VDR knockdown inhibited the proliferation of CML cells driven by both BCR::ABL1 and TKI-resistant BCR::ABL1 mutations. Mechanistically, VDR transcriptionally regulated DDIT4 expression; reduced DDIT4 levels upon VDR knockdown triggered DNA damage and senescence via p53 signaling activation in CML cells. Furthermore, VDR deficiency not only suppressed tumor burden and progression in primary CML mice but also reduced the self-renewal capacity of CML-LSCs. Together, our study demonstrated that targeting VDR is a promising strategy to overcome TKI resistance and eradicate LSCs in CML.
Asymptomatic colo-ovarian fistula amidst acute psychosis: a case report
Authors: Mansour Meghan R , Kessler Steven A , Khreisat Ali , Skrzynski Justin K 
Published: October 2023

Abstract
This paper presents a rare case of an asymptomatic colo-ovarian fistula in a 45-year-old female with acute psychosis and a history of bipolar disorder, seizure disorder and substance misuse. The intricate diagnostic challenges arising from the patient’s complex medical history underscore the significance of a multidisciplinary approach. The absence of typical gastrointestinal symptoms and the presence of a tubo-ovarian abscess complicated the diagnosis of acute on chronic sigmoid diverticulitis and colo-ovarian fistula. Surgical intervention, including sigmoid resection, anastomosis and left salpingo-oophorectomy, led to successful resolution. This case highlights the need for further understanding of colo-ovarian fistula pathophysiology, improved diagnostic strategies, and the nuanced interplay between medical and psychiatric conditions in complex clinical scenarios.
Case report: repair of eventration of the diaphragm in an octogenarian
Authors: Forter-Chee-A-Tow Ninon , Smith Alan 
Published: October 2023

Abstract
Eventration of the diaphragm is a cephalad displacement of the diaphragm because of congenital or acquired causes. The diaphragm maintains its anatomical continuity and normal attachments. It may be partial or complete and unilateral or bilateral. Most adult presentations are asymptomatic, but patients may present with respiratory, gastrointestinal, or cardiac symptoms. Surgical repair is indicated in the symptomatic patient with the most common being diaphragmatic plication. We present surgical repair of a symptomatic left diaphragmatic eventration in an octogenarian.
Location: root architecture structures rhizosphere microbial associations
Authors: Galindo-Castañeda Tania , Hartmann Martin , Lynch Jonathan P 
Published: October 2023

Abstract
Root architectural phenotypes are promising targets for crop breeding, but root architectural effects on microbial associations in agricultural fields are not well understood. Architecture determines the location of microbial associations within root systems, which, when integrated with soil vertical gradients, determines the functions and the metabolic capability of rhizosphere microbial communities. We argue that variation in root architecture in crops has important implications for root exudation, microbial recruitment and function, and the decomposition and fate of root tissues and exudates. Recent research has shown that the root microbiome changes along root axes and among root classes, that root tips have a unique microbiome, and that root exudates change within the root system depending on soil physicochemical conditions. Although fresh exudates are produced in larger amounts in root tips, the rhizosphere of mature root segments also plays a role in influencing soil vertical gradients. We argue that more research is needed to understand specific root phenotypes that structure microbial associations and discuss candidate root phenotypes that may determine the location of microbial hotspots within root systems with relevance to agricultural systems.
Liver regeneration
Authors: Humar Bostjan , Humar Rok 
Published: October 2023

Abstract
The liver is the only mammalian organ capable of complete recovery following major tissue loss. Intense research has revealed the profound complexity behind liver regeneration, rightly considered to be one of the most intriguing processes within the human body. This chapter provides a concise overview of key findings, interpreted to highlight the general principles that underlie the restoration of liver mass. Following a descriptive view of the regenerative process, mechanistic insights are given on priming, progression, vascular reconstitution, and termination—the major phases of liver regeneration. Given the central tasks of the liver, metabolic disturbances arising following tissue loss are emerging as crucial regulators of regeneration and are likewise discussed. The chapter closes with three pressing medical issues (post-hepatectomy liver failure, steatosis, and fibrosis) that compromise successful recovery, describing potential causes associated with the underlying pathobiology.
Perioperative management and nutrition in patients with liver and biliary tract disease
Authors: Rajakumar Akila , Kaliamoorthy Ilankumaran , Kanagavelu Rathnavel G. 
Published: October 2023

Abstract
Patients with liver and biliary tract disease present unique critical challenges to the perioperative physician. Involvement of a multidisciplinary team with expertise in handling critically ill patients with cirrhosis, a thorough understanding and evaluation of the altered pathophysiology in this cohort of patients, and meticulous planning of timing and other perioperative strategies can help to achieve better outcomes during patients’ perioperative course. Risk minimization with attempts to optimize inherent conditions in various organ systems should be performed whenever possible, especially for elective surgeries. It is also important to decide when to defer surgery and the patient’s family should be involved in making an informed decision.
Modern management of liver trauma
Authors: Müller Philip C. , Neuhaus Valentin , Pfammatter Thomas , Petrowsky Henrik 
Published: October 2023

Abstract
Following trauma, the liver is one of the organs of the abdominal cavity which is most often injured. Historically, liver trauma was associated with a high morbidity and mortality mainly from an aggressive surgical approach. During the last 25 years, however, there has been a paradigm shift away from aggressive surgical techniques towards damage control surgery. With the introduction of computed tomography, non-operative management has become the standard of care for blunt liver trauma in haemodynamically stable patients. Still, surgeons often face demanding challenges in the hostile environment of actively bleeding livers, while resection techniques as in elective hepatic surgery cannot be applied. This chapter presents the current approach to hepatic trauma, describing its pathophysiology, classification, diagnostic workup, non-operative management, and surgical management.
Cholangiocarcinoma
Authors: Rela Mohamed , Reddy Mettu Srinivas 
Published: October 2023

Abstract
Cholangiocarcinomas are a group of malignancies originating from the biliary epithelium. They are classified according to their location of origin into intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, and distal cholangiocarcinoma. Cholangiocarcinomas are slow-growing tumours, seen after the sixth decade of life, which usually present late in their natural history. Surgery with negative margins is the only treatment option which is potentially curative, though less than a third of these tumours are resectable at presentation. Recent advances in preoperative optimization techniques, aggressive surgery with vascular resection, and better postoperative management has improved their resection rates and overall survival.
Secondary neoplasms of the liver
Authors: Line Pål-Dag 
Published: October 2023

Abstract
Secondary liver tumours are metastases from primary tumours elsewhere and constitute the largest group of malignant hepatic tumours. The liver involvement dictates survival probability in the majority of patients, and surgical resection is the only potential curative therapeutic option. Colorectal liver metastasis is the most common type. Liver resection is the standard of care for colorectal liver metastasis and overall 5-year survival following resection is about 42%, dependent on a range of prognostic factors. Metastases from neuroendocrine tumours may be treated by hepatic resection with a 5-year survival of 50–75%. Liver transplantation is an option for carefully selected patients with non-resectable liver metastases from neuroendocrine tumours with 5-year survival of greater than 80% and a low risk of recurrence. For other types of metastases, like breast cancer, urological and gynaecological cancer, gastrointestinal stromal tumours, and sarcomas, surgical therapy may be efficacious, particularly in young patients with oligometastatic disease, long disease-free interval, and favourable tumour biology.