bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Baduanjin Qigong on Sleep Quality and Hyperarousal State in Adults With Chronic Insomnia: Protocol for a Randomized Controlled Trial
Authors: Xie Chaoqun , Xie Fangfang , Ma Jianwen , Yue Hongyu , You Yanli , Yao Fei 
Published: December 2023

Background
Chronic insomnia (CI) is a mind-body disease that is commonly defined as a state of having disturbed daytime activities due to poor nighttime sleep quality. Baduanjin qigong (BDJQG) is widely used for CI in China. However, there is little scientific evidence to evaluate its effects on the hyperarousal state, which is closely associated with improved sleep quality.

Objective
The objective of the trial is to assess the therapeutic effects of BDJQG on sleep quality in patients with CI.

Methods
A randomized controlled trial will be conducted on 86 patients, who will be divided into a BDJQG group and a cognitive behavioral therapy for insomnia group at a ratio of 1:1. Interventions in both groups will be given to the participants 7 times a week for 8 weeks, and the participants will be followed up for 4 weeks. The primary outcome is the change in the Pittsburgh Sleep Quality Index from baseline to week 8. The secondary outcomes are the changes in the Hyperarousal Scale, Insomnia Severity Index, Fatigue Scale-14, wrist actigraphy, salivary cortisol level, and functional magnetic resonance imaging from baseline to week 8. All main analyses will be carried out on the basis of the intention-to-treat principle.

Results
This study was funded from January 2023. As of the submission of the manuscript, there were 86 participants. Data collection began in April 2023 and will end in January 2024. Data analysis is expected to begin in January 2024, with the publication of results expected in February 2024.

Conclusions
This study will present data concerning the clinical effects of BDJQG on CI. The results will help to demonstrate whether BDJQG is an effective therapy for improving sleep quality in association with a decreased hyperarousal level as a possible underlying mechanism. This study will provide much-needed knowledge for complementary and alternative therapy for patients with CI.

Trial Registration
China Clinical Registration Agency ChiCTR2300069241; https://chictr.org.cn/bin/project/ChiCTR2300069241

International Registered Report Identifier (IRRID)
PRR1-10.2196/53501
Incidence and Characteristics of the Hyperosmolar Hyperglycemic State: A Danish Cohort Study
Authors: Rosager Emilie V. , Heltø Amalia Lærke K. , Fox Maule Cathrine U. , Friis-Hansen Lennart , Petersen Janne , Nielsen Finn E. , Haugaard Steen B. , Gregersen Rasmus 
Published: December 2023

OBJECTIVE
The hyperosmolar hyperglycemic state (HHS) is a rare and life-threatening complication of diabetes. We aimed to estimate the incidence of HHS and describe the clinical and biomarker profiles of patients with HHS, including subgroups with acidosis and acute kidney injury.

RESEARCH DESIGN AND METHODS
This nationwide, descriptive cohort study used Danish registry data during years 2016–2018 to identify acutely admitted patients fulfilling the hyperglycemia and hyperosmolarity criteria of HHS (glucose ≥33 mmol/L and osmolarity [2 × sodium + glucose] ≥320 mmol/L).

RESULTS
We identified 634 patients (median age, 69 years (first quartile; third quartile: 58; 79) who met the criteria of HHS among 4.80 million inhabitants aged ≥18 years. The incidence rates were 16.5 and 3.9 per 10,000 person-years among people with known type 1 (n = 24,196) and type 2 (n = 251,357) diabetes, respectively. Thirty-two percent of patients with HHS were not previously diagnosed with diabetes. Patients were categorized as pure HHS (n = 394) and combined HHS and diabetic ketoacidosis (HHS-DKA; n = 240). The in-hospital mortality rate for pure HHS was 17% and 9% for HHS-DKA.

CONCLUSIONS
The incidence of HHS was higher among patients with type 1 diabetes compared with type 2 diabetes. HHS is a spectrum of hyperglycemic crises and can be divided in pure HHS and HHS-DKA. In one-third of patients, HHS was the debut of their diabetes diagnosis.
Assessment of Glycemic Control by Continuous Glucose Monitoring, Hemoglobin A1c, Fructosamine, and Glycated Albumin in Patients With End-Stage Kidney Disease and Burnt-Out Diabetes
Authors: Kaminski Candice Y. , Galindo Rodolfo J. , Navarrete Jose E. , Zabala Zohyra , Moazzami Bobak , Gerges Amany , McCoy Rozalina G. , Fayfman Maya , Vellanki Priyathama , Idrees Thaer , Peng Limin , Umpierrez Guillermo E. 
Published: December 2023

OBJECTIVE
Patients with diabetes and end-stage kidney disease (ESKD) may experience “burnt-out diabetes,” defined as having an HbA1c value &lt;6.5% without antidiabetic therapy for &gt;6 months. We aim to assess glycemic control by continuous glucose monitoring (Dexcom G6 CGM) metrics and glycemic markers in ESKD patients on hemodialysis with burnt-out diabetes.

RESEARCH DESIGN AND METHODS
In this pilot prospective study, glycemic control was assessed by continuous glucose monitoring (CGM), HbA1c measures, and glycated albumin and fructosamine measurements in patients with burnt-out diabetes (n = 20) and without a history of diabetes (n = 20).

RESULTS
Patients with burnt-out diabetes had higher CGM-measured daily glucose levels, lower percent time in the range 70–180 mg/dL, higher percent time above range (&gt;250 mg/dL), and longer duration of hyperglycemia &gt;180 mg/dL (hours/day) compared with patients without diabetes (all P &lt; 0.01). HbA1c and fructosamine levels were similar; however, patients with burnt-out diabetes had higher levels of glycated albumin than did patients without diabetes.

CONCLUSIONS
The use of CGM demonstrated that patients with burnt-out diabetes have significant undiagnosed hyperglycemia. CGM and glycated albumin provide better assessment of glycemic control than do values of HbA1c and fructosamine in patients with ESKD.
Assessing Genetic Variability in Wheat (Triticum aestivum L.) Under Timely and Late Sown Conditions for Tolerance Towards Terminal Heat Stress
Authors: Karla Uttej , Choudhary Vinay Kumar , Singh Satish Kumar , Vignesh S. , Ellandula Anvesh 
Published: December 2023

A field experiment was conducted at wheat experimental farm, Post Graduate College of Agriculture, DRPCAU, Pusa, Bihar to quantify the genetic variability among twenty-nine wheat genotypes under timely and late sowing conditions for tolerance towards terminal heat stress during rabi 2020–2021. The trial was performed in three replications using Randomized Block Design. The study included estimates of genetic variability parameters such as mean, range, phenotypic coefficient of variability, genotypic coefficient of variability, broad-sense heritability, and genetic advance over % of mean. The ANOVA estimations showed that there’s considerable variation across genotypes for all twelve traits investigated across both environments. Traits like grains spike-1 and harvest index displayed considerable genotypic and phenotypic variances across both environments indicating the relevance of these traits in stress conditions. Tillers plant-1 and grain yield plant-1 displayed high genotypic and phenotypic coefficient of variation in timely and late conditions respectively. High heritability reported for traits like days to 50% flowering, canopy temperature, harvest index, grain yield plant-1, tillers plant-1, thousand grain weight and grains spike-1 in both conditions. Under both conditions, tillers plant-1, grains spike-1, harvest index and grain yield plant-1 reported strong heritability along with high genetic advance over % of mean. As a result, direct selection may be made using these features for further genotype improvement under stress conditions for improved heat tolerance.
Pengaruh jalinan lalu-lintas terhadap tundaan di Jalan Imam Bonjol dengan metode gap acceptance
Authors: Rama Muhammad Ichsan Syaditya , Junaedi Tas’an , Sulistyorini Rahayu 
Published: December 2023

Di Jalan Imam Bonjol terdapat jalinan simpang dari Jalan Mangkubumi ke Jalan Sultan Badarudin, yang pada saat jam sibuk menyebabkan kemacetan dengan antrian yang panjang dan lamanya waktu tundaan. Oleh sebab itu, penelitian ini bertujuan untuk menganalisis tundaan menggunakan metode gap acceptance dan mengetahui tingkat pelayanan di simpang Jalan Imam Bonjol. Beberapa karakteristik di simpang yang di analisis adalah kecepatan, gap, gap kritis dan tundaan. Hasil penelitian menunjukkan ke-cepatan kendaraan sangat terpengaruh oleh weaving menyebabkan kecepatannya lebih rendah. Selain itu, besarnya rata-rata tundaan di pagi hari sebesar 42,3 detik dan di sore hari sebesar 52,8 detik pada interval waktu tiap 5 menit, sehingga tingkat pelayanan simpang pada Jalan Imam Bonjol adalah E. Setelah solusi pelebaran jalan 0,5 m per lajur disimulasikan menggunakan software vissim, didapatkan tingkat pelayanan simpang menjadi B.
Antibacterial Potential of Chitosan Scaffolds Incorporated with Oregano and Thyme Essential Oils against Escherichia coli
Authors: Torres José Lucas Medeiros , Silva Sonaly de Lima , Medeiros Maria Alice Araújo de , Alves Millena de Souza , Bezerra Márcia Maria de Siqueira Leite , Mariz Waldo Silva , Oliveira Elaine Bezerra de , Silva Emanoel Vitor Alves da , Guênes Gyselle Tenório , Guênes Gymenna Maria Tenório , Medeiros Luanna Abílio Diniz Melquíades de , Fook Marcus Vinicius Lia , Sousa Wladymyr Jéfferson Bacalhau de , Oliveira Filho Abrahão Alves de 
Published: December 2023

The aim of this study was to evaluate the antibacterial potential of chitosan-based scaffolds associated with the essential oils of Origanum vulgare L. and Thymus vulgaris L. against a strain of Escherichia coli. The antibacterial potential was assessed by reading the inhibition halos formed around the chitosan-based scaffolds incorporated with thyme EO, oregano EO and thyme and oregano EO against the Escherichia coli strain, using the Mueller Hinton agar diffusion methodology per well. To do this, Mueller Hinton Agar was used as the culture medium in Petri dishes, and holes 6 mm in diameter were formed using a mold to create the wells. The plates were inoculated with the microorganism using a swab, then incubated in a bacteriological oven at 37 °C for 24 hours. Scaffolds, in the form of disks, were aseptically deposited in the wells of the inoculated media, which were incubated at 37 °C for 24 hours. After incubation, the plates were observed for homogeneity of bacterial growth and the diameter of the inhibitory halo was measured using a millimeter ruler in cases where inhibition of bacterial growth was verified. The tests were carried out in duplicate and the results correspond to the average values. The association of chitosan with Origanum vulgare L. and Thymus vulgaris L. EOs was found to have antibacterial activity against the Escherichia coli strain. For the scaffolds incorporated with Origanum vulgare L. EO, Thymus vulgaris L. EO and associated Origanum vulgare L. and Thymus vulgaris L. EOs, 16 mm inhibition halos were formed against the Escherichia coli strain. The association of chitosan with the EOs of Origanum vulgare L. and Thymus vulgaris L. has antibacterial activity, acting as a bactericide against the Escherichia coli strain tested.
АССОЦИАЦИЯ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНОВ HHIP, ADRB2 И ИЛ-33 С КЛИНИЧЕСКИМИ ПРОЯВЛЕНИЯМИ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ
Authors: Алиева Юлия , Фурман Евгений , Кондратьева Елена , Лошкова Елена , Шелудько Валерий , Соколовский Владимир , Хузина Екатерина , Пономарева Мария , Айшауова Раушан 
Published: December 2023

Проведенное исследование полиморфизмов генов HHIP, ADRB2 и IL-33 у детей, страдающих БА, с разными фенотипами заболевания выявило ассоциацию между полиморфизмами генов и тяжестью заболевания, а также с сопутствующими заболеваниями.
Показано, что генотип ТТ генетического варианта rs12504628 (T>C) гена HHIP снижает риск реализации тяжелой БА, однако увеличивает в 2,8 раза риск сочетанного с БА атопического дерматита. Генотип СС+СТ гена HHIP в 2,9 раза увеличивает риск реализации лекарственной аллергии на фоне БА.
Генотипа АА гена ADRB2 ассоциирован со снижением риска реализации врожденных пороков развития трахеобронхиального дерева на фоне БА. Полиморфные варианты в 4 и 6 экзонах гена IL-33 чаще сочетаются со среднетяжелой и тяжелой астмой, а замены нуклеотидов в экзонах 4 и 6 ассоциированы с тяжелым течением БА.
Таким образом, в данном исследовании установлены ассоциации полиморфных вариантов генов HHIP, ADRB2 и IL-33 с клиническими проявлениями бронхиальной астмы у детей, которые могут учитываться при персонализированном наблюдении за этими пациентами, и могут помочь в достижении полного контроля над заболеванием.
Analisis Faktor- Faktor Yang Memotivasi Mahasiswa Dalam Berinvestasi Saham Pada Aplikasi Ajaib (Studi Kasus Pada Mahasiswa Universitas Muhammadiyah Metro)
Authors: Japlani Ardiansyah , Dupri Muhammad Demsi , Anita Ria 
Published: December 2023

Adequate knowledge of the correct investment methods is crucial to avoid losses wheninvesting in stock market applications, such as Ajaib. The growth of investors in Ajaib'sapplication is considered quite good. However, when compared to other countries, theinvestment awareness among the Indonesian population is still relatively low. The presenceof numerous new companies can be one of the driving factors for increasing the number ofinvestors, especially in stock market investments through Ajaib's application. However, thesheer number of companies alone may not significantly impact the growth of investors if theawareness of investment among students remains low. The purpose of this research is todetermine the combined influence of interest, profit, and self-efficacy on stock marketinvestments through Ajaib's application among students at Muhammadiyah University Metro.This research uses a quantitative approach, and the research method involves the Slovin formula for sample determination. The sample consists of 56 students from the 2018 class inthe Faculty of Economics and Business at Muhammadiyah University Metro. The dataanalysis techniques include validity testing, reliability testing, normality testing, linearitytesting, and homogeneity testing. The analytical model used in this research includes multiplelinear regression analysis, T-test, F-test, and R-squared determination. Based on theresearch results, the T-test indicates that interest significantly influences stock marketinvestments through Ajaib's application among students at Muhammadiyah University Metro.Profit also has a significant influence on stock market investments through Ajaib'sapplication among these students. On the other hand, self-efficacy does not have a significanteffect on stock market investments through Ajaib's application among students atMuhammadiyah University Metro. The F-test results show that interest, profit, and selfefficacy together have a significant influence on stock market investments through Ajaib'sapplication among students at Muhammadiyah University Metro
Pengaruh Kepercayaan, Keamanan Transaksi, Harga, Kualitas Pelayanan, Dan Persepsi Akan Risiko Terhadap Keputusan Pembelian Pada Konsumen E-Commerce Shopee Studi Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Muhammadiyah Metro
Authors: Widodo Deny Edy , Ratmono Ratmono , Mustakim Rahmat 
Published: December 2023

The development and progress of information technology is currently growing very rapidlyand is very influential in everyday life, especially life in Indonesia. All of this can be seenfrom the large and large number of internet users in Indonesia, there must be a reason, oneof which is the development of infrastructure and the second is easy to get gadgets at lowprices. This study aims to 1) To find out whether there is an influence of trust on purchasingdecisions on Shopee E-commerce consumers on students at the University of Muhamadiyah Metro. 2) To find out whether there is a security effect on purchasing decisions on Shopee Ecommerce consumers at the University of Muhamadiyah Metro students. 3) To find outwhether there is an effect of price on purchasing decisions on Shopee E-commerceconsumers at the University of Muhamadiyah Metro students. 4) To find out whether there isan effect of service quality on purchasing decisions for E-commerce consumers throughShopee for students at the University of Muhammadiyah Metro. 5) To find out whether thereis an effect of perception of risk on purchasing decisions on Shopee E-commerce consumersfor students at the University of Muhammadiyah Metro. 6) To find out whether there is aneffect of trust, security, price, service quality, and perception of risk on purchasing decisionson Shopee E-commerce consumers at Muhamadiyah Metro University students... In thisstudy, the population was FEB students, Muhammadiyah University Metro Teknik samplingusing accidental sampling with a total sample of 72 people. Data collection techniques usinga questionnaire with a Likert scale. The results show that 1) there is a positive and significantinfluence between trust on purchasing decisions. 2) there is a positive and significantinfluence between security on purchasing decisions. 3) there is a positive and significanteffect of price on purchasing decisions 4) there is a positive and significant influence on thequality of service on purchasing decisions 5) there is a positive and significant influence onthe perception of risk on purchasing
Comportamiento de visitantes en el Sendero Laguna Esmeralda, Ushuaia
Authors: Villegas Maria Lucrecia , Cárdenas Romero Silvina Adriana , Vereda Marisol 
Published: December 2023

La actividad del senderismo en su desarrollo como práctica turística se relaciona con las tendencias turísticas actuales, vinculadas con la vuelta a la naturaleza, la mejora del bienestar psico-físico y la búsqueda de experiencias significativas. En base a este contexto, el presente estudio se centra en analizar el comportamiento de turistas en el Sendero Laguna Esmeralda, ubicado en las afueras de Ushuaia, provincia de Tierra del Fuego, A.I.A.S. Se aplicó un enfoque metodológico cualitativo mediante la observación directa no participante, con un posterior análisis cuantitativo descriptivo. Los resultados demuestran que, en términos generales, los caminantes poseen una baja experiencia en senderismo y, sin embargo, generan una interacción positiva y altamente satisfactoria con el ambiente de montaña y sus componentes. Los hallazgos obtenidos resultan útiles para contribuir con la planificación y gestión, tanto del sendero de estudio como para la actividad de senderismo en la región.
Gainza, C. y Zúñiga, C. Cartografía de la literatura digital latinoamericana. Visualización, archivo y preservación de obras literarias digitales, 2018-2021
Authors: Botero Betancur Constanza 
Published: December 2023

Reseña crítica del proyecto de las investigadoras Carolina Gainza y Carolina Zúñiga et al. Cartografía de la literatura digital latinoamericana. Visualización, archivo y preservación de obras literarias digitales. Laboratorio Digital de la Facultad de Comunicación y Letras de la Universidad Diego Portales. https://www.cartografiadigital.cl/
A new method using deep transfer learning on ECG to predict the response to cardiac resynchronization therapy
Authors: He Zhuo , Si Hongjin , Zhang Xinwei , Chen Qinghui , Zou Jiangang , Zhou Weihua 
Published: December 2023

Background: Cardiac resynchronization therapy (CRT) has emerged as an effective treatment for heart failure patients with electrical dyssynchrony. However, accurately predicting which patients will respond to CRT remains a challenge. This study explores the application of deep transfer learning techniques to train a predictive model for CRT response. Methods: In this study, the short-time Fourier transform (STFT) technique was employed to transform ECG signals into two-dimensional images. A transfer learning approach was then applied to the MIT-BIT ECG database to pre-train a convolutional neural network (CNN) model. The model was fine-tuned to extract relevant features from the ECG images and then tested on our dataset of CRT patients to predict their response. Results: Seventy-one CRT patients were enrolled in this study. The transfer learning model achieved an accuracy of 72% in distinguishing responders from non-responders in the local dataset. Furthermore, the model showed good sensitivity (0.78) and specificity (0.79) in identifying CRT responders. The performance of our model outperformed clinic guidelines and traditional machine learning approaches. Conclusion: The utilization of ECG images as input and leveraging the power of transfer learning allows for improved accuracy in identifying CRT responders. This approach offers potential for enhancing patient selection and improving the outcomes of CRT.
Rules for the construction of firebreaks along public roads in selected European countries
Authors: Tyburski Łukasz , Szczygieł Ryszard 
Published: December 2023

Abstract
Firebreaks are one of the protective measures used to safeguard forests in case of fire. Their purpose is to limit the possibility of fire spreading. This article describes how these protective measures are implemented along public roads in selected European countries. Based on the information gathered, it was found that there is a wide variety of approaches to firebreaks’ construction, mostly due to different climatic and geomorphological conditions that influence the overall risk of forest fires. The forms of firebreaks used in Europe along public roads are either a mineralised belt (without vegetation) or a cleared belt of materials that are particularly susceptible to ignition and fire spread. Methods combining both are also used.
In Poland, there is a Type A belt, that is, a 30-m-wide belt at the border of a roadway or a facility that is free of dead trees, lying branches and felled or broken trees. In the absence of pan-European rules on preventive measures to protect forests from road fires, it might be helpful to establish a set of best practices that could assist in the revision of guidelines in individual countries.
Enhancing PV Systems with Intelligent MPPT and Improved control strategy of Z-Source Inverter
Authors: Bettahar Fares , Sabrina Abdeddaim , Achour Betka 
Published: December 2023

Abstract
The Improved Z-Source Inverter (IZSI) has gained attention in the photovoltaic industry for its ability to boost PV voltage with a single-stage topology, simplifying system design and reducing costs. However, research on integrating IZSI into PV systems, particularly regarding the Maximum Power Point Tracker (MPPT) and IZSI control strategy, is limited. This study proposes an Intelligent Improved Particle Swarm Optimization (IPSO) algorithm as an MPPT method for PV systems under constant and varying irradiance conditions. The IPSO algorithm is compared to the FPA, CSA, and traditional MPPT algorithm (PSO), and the results demonstrate that IPSO outperforms all algorithms in terms of speed, efficiency, and convergence in finding the Maximum Power Point (MPP). Two methods, Simple Boost Control (SBC) and Maximum Constant Boost Control with Third Harmonic Injection (THIMCBC), are employed to control IZSI. Simulation results using MATLAB-Simulink show that both strategies successfully find and track the MPP, but THIMCBC exhibits superior voltage-boosting performance compared to SBC. Overall, the proposed IZSI topology with the IPSO MPPT method and THIMCBC IZSI control strategy offers several advantages, including improved voltage boost ability, reduced z-source capacitor voltage stress, inherent inrush current limitation, and cost-effectiveness. These advantages make the proposed system a promising solution for photovoltaic systems.