bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating a Hybrid Lightweight Consensus Algorithm in HyperLedger Fabric
Authors: Michalopoulos Fotis , Vavilis Sokratis , Niavis Harris , Loupos Konstantinos 
Published: January 2025

Abstract
In today’s interconnected IoT ecosystems, blockchain technology acts as a facilitator for decentralization. Hyperledger Fabric (HLF) is a renounced permissioned blockchain platform designed for enterprise use. Currently, HLF supports two primary consensus algorithms: Raft and smartBFT. Despite HLF’s modular nature, integrating new consensus algorithms remains a challenging and intricate process that lacks sufficient guidelines. In this work, we bridge this gap by providing a novel, comprehensive, yet practical guide to simplify the integration of consensus algorithms into HLF. Furthermore, we demonstrate our approach by integrating a new hybrid algorithm into HLF, specifically tailored for the IoT ecosystem. Compared to the current algorithms, experiments indicate promising performance and reliability.
Leveraging the Industrial Internet of Things (IIoT) for Real-Time CO2 Monitoring, Measurement and Visualization: Technologies, Applications and Future Directions
Authors: Christensen Mads S-F. 
Published: January 2025

Abstract
Global CO2 emissions reduction requires industries to manage and understand their CO2 emission levels in real-time. This paper examines the Industrial Internet of Things (IIoT) for real-time monitoring, measurement, and visualization of reducing CO2 emissions in industrial and environmental domains.

Methodology: The methodology consists of a literature review based on peer-reviewed publications and use cases to explore the current state and practical implications. Furthermore, a technical analysis of IIoT systems, CO2 sensors, and data processing techniques is also identified.

Results: IIoT systems can support CO2 emission monitoring and accuracy optimization in industrial domains by combining CO2 sensors, wireless communication, and data fusion techniques. In addition, machine learning and artificial intelligence can be used to reduce anomalies in CO2 sensor readings and predictive maintenance of systems.

Challenges: Challenges include interoperability, data security and system scalability. To resolve these issues standardized communication protocols, data security methods and implementation barriers should be improved.

Future Directions: To enhance data processing and security features, future work should focus on integrating edge computing, artificial intelligence, machine learning, and blockchain techniques. In addition, data visualizations and cost-effective solutions should also be in focus, to provide more adoptable IIoT systems in industrial domains.

Conclusion: As IIoT systems and CO2 sensor technologies evolve, IIoT systems can contribute significantly to increasing global air quality and CO2 emission control in industry, agricultural, and urban areas.
Privacy Preserving Enablers for Data Space Ecosystems
Authors: García Natalia Borgoñós , Padilla María Hernández , Gómez Antonio Fernando Skarmeta 
Published: January 2025

Abstract
Data Spaces are ecosystems designed to allow multiple organizations or companies to share data in a secure manner. Despite the potential of these technologies, they encounter a number of challenges and privacy issues that limit their use. Privacy Preserving Enablers are mechanisms developed to tackle these difficulties, ensuring data integrity and access control. This paper aims to analyze the role of some Privacy Preserving Enablers and its integration with Connectors in the context of Data Spaces. The research will focus on key enablers, including a Self-Sovereign Identity with Zero-Knowledge Proof, which is a privacy preserving approach that allows users to verify their identity and attributes without the need to disclose underlying data, ensuring their privacy. Additionally, the usage of Sticky Policies instantiated through Attribute-Based Encryption attaches control policies into the encrypted data in order to have an attribute-based access control, enhancing its security. The application of Policies Enforcement assure the consistent application of policies and the maintenance of the security within the Data Space.
Postoperative accuracy quantification of corrective osteotomies: standardisation of Q3D-CT methodology
Authors: Tabernée Heijtmeijer Sander J. C. , Meesters Anne M. L. , Verdonschot Nico J. J. , Jutte Paul C. , Doornberg Job N. , Pijpker Peter A. J. , Kraeima Joep 
Published: January 2025

Abstract

Purpose
Currently, no gold standard exists for 3D analysis of virtually planned surgery accuracy postoperatively. The aim of this study was to present a new, validated and standardised methodology for 3D postoperative assessment of surgical accuracy in patients undergoing 3D virtually planned and guided corrective osteotomies.

Methods
All patients who underwent 3D planned corrective osteotomy in 2021–2022 at our center with a postoperative CT were included. Postoperative surgical outcome was analysed with a postoperative CT and compared to the preoperative virtual surgical planning to determine achieved accuracy. Validation of the analysis was performed by evaluating the individual assessment of six experienced observers. A postoperative quantification was performed according to the proposed innovative methodology based on rotation axes of a virtual postoperative bone model aligned to the virtual preoperative bone model and virtual surgical planned bone model. To evaluate the intra-observer variability, one observer performed the assessment twice.

Results
Quantification of 13 patients according resulted in measurements with a median range (and its interquartile range) for 3D translation of: 2.43 mm (3.17), for the angle deviations: 3D rotation, 2D coronal, 2D sagittal and 2D axial were: 0.66° (1.66°), 0.74° (0.44°), 0.99° (1.27°), 2.37° (5.00°), respectively. The inter- and intraobserver reliability established with the Intraclass correlation coefficient was for all measurements excellent (> 0.76).

Conclusion
The proposed 3D CT technique provides an significant more accurate and objective method for assessment of surgical outcome of a guided corrective osteotomy. The present proposed novel methodology showed excellent inter- and intra-observer reliability with clinically acceptable absolute surgical outcome measurements.
Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study
Authors: Lalla Louisa Telsche , Czorlich Patrick , Fischer Marlene , Schweingruber Nils , Cramer Christopher , Frosch Karl-Heinz , Gempt Jens , Kluge Stefan , Grensemann Jörn 
Published: January 2025

Abstract

Purpose
In patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO2) only leads to minor increase in cerebral oxygen delivery but can cause numerous pathophysiological disturbances. Therefore, we aimed to study effects of hyperoxia on patient outcome and identify optimum PaO2 ranges.

Methods
This retrospective, single-center cohort study included TBI patients receiving mechanical ventilation for ≥ 72 h. Time-weighted mean PaO2 and integrals above thresholds of 80, 100, 120, and 150 mmHg were calculated over periods of 1, 3, 7, and 14 days. The effects on in-hospital mortality and favorable functional outcome defined as Glasgow Outcome Scale (GOS) ≥ 4 were explored at discharge and after 3–6 months.

Results
From 01/2013 until 12/2021, 290 patients fulfilled the inclusion criteria. Hyperoxia was dose-dependently associated with a worsened functional outcome 3–6 months post-injury. Regarding the first 24 h, odds ratios were 0.959 (95% confidence intervals: 0.932–0.990; p = 0.009) for time-weighted mean PaO2 and 0.955 (0.923–0.988; p = 0.008), 0.939 (0.897–0.982; p = 0.006), 0.923 (0.871–0.978; p = 0.007) and 0.922 (0.858–0.992; p = 0.029) per mmHg above 80, 100, 120 and 150 mmHg, respectively. For exposure within 72 h, odds ratios were 0.897 (0.819–0.983; p = 0.020), 0.842 (0.738–0.961; p = 0.011) and 0.832 (0.705–0.981; p = 0.029) per mmHg per day over 100, 120 and 150 mmHg, respectively. No significant association could be established between PaO2-exposure and in-hospital mortality, GOS at discharge or the 7- and 14-day periods.

Conclusion
In this cohort, hyperoxia within 72 h after admission was dose-dependently associated with an unfavorable neurological outcome after 3–6 months.
On the Enumeration of Arf Numerical Semigroups with Given Multiplicity and Conductor
Authors: Karakaş Halil İbrahim , Tutaş Nesrin 
Published: January 2025

Abstract
Let

$$N_{ARF}(m,\mathscr {C})$$

N

ARF

(
m
,
C
)

denote the number of Arf numerical semigroups with multiplicity m and conductor

$$\mathscr {C}$$

C

. In an earlier paper of the first author (Semigroup Forum 105:478–487, 2022), it was proved that

$$N_{ARF}(m,\mathscr {C})$$

N

ARF

(
m
,
C
)

depends only on the congruence class of

$$\mathscr {C}$$

C

modulo m if m is prime. In the same paper, it was noticed that there are composite numbers m for which

$$N_{ARF}(m,\mathscr {C})$$

N

ARF

(
m
,
C
)

depends only on the congruence class of

$$\mathscr {C}$$

C

modulo m for some congruence classes, and the author had posed the question of characterizing such m and congruence classes of m for which

$$N_{ARF}(m,\mathscr {C})$$

N

ARF

(
m
,
C
)

is an invariant of those classes. We prove that

$$N_{ARF}(m,\mathscr {C})$$

N

ARF

(
m
,
C
)

is an invariant of the congruence class of

$$\mathscr {C}$$

C

(mod m) if and only if

$$m = p^n$$

m
=

p
n

and

$$\mathscr {C} \equiv (tp^{n-1}+1) \ (\textrm{mod}\ p^n)$$

C
≡

(
t

p

n
-
1

+
1
)

(
mod

p
n

)

where

$$n\in {\mathbb {N}}$$

n
∈
N

, p is prime,

$$t \in \{1, \ldots , p-1\}$$

t
∈
{
1
,
…
,
p
-
1
}

.
Central nervous system involvement in Waldenström macroglobulinemia: a comparative population-based study of Bing-Neel syndrome and histological transformation
Authors: Østergaard Simon , Munksgaard Lars , Hammer Troels , Nielsen Torsten Holm , Pedersen Mette Ølgod , Gjerdrum Lise Mette Rahbek 
Published: January 2025

Abstract
Central nervous system (CNS) involvement in Waldenström macroglobulinemia (WM) is a rare complication that can manifest as Bing-Neel syndrome (BNS) or as histological transformation (HT) to diffuse large B-cell lymphoma (DLBCL). We report data from a single-center cohort of 469 patients consecutively diagnosed with WM between 2000 and 2022. BNS was identified in 1.5% (n = 7) and HT with CNS involvement (CNS-HT) in 1.7% (n = 8) of patients. The cumulative incidence of BNS and CNS-HT at 15 years was 2.6% and 2.7%, respectively, with CNS-HT more likely to develop in closer proximity to the initial WM diagnosis. One patient with CNS-HT exhibited a preceding phase of BNS before transformation. In general, patients with BNS and CNS-HT presented with diverse neurological symptoms and clinical features. Parenchymal lesions were uniformly found in all patients with CNS-HT, while neuroimaging findings were less consistent in patients with BNS. Involvement of multiple extramedullary sites was observed in approximately half of the patients with both BNS and CNS-HT. Patients with CNS-HT had poor outcomes, with a median overall survival of 10 months following the onset of CNS involvement, whereas BNS was associated with a more favorable prognosis, particularly in patients treated with ibrutinib. This study is the first to present a comparative analysis of BNS and CNS-HT in WM, providing novel insights into their incidence, clinical features, and outcomes.
HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC
Authors: Funaishi Kunihiko , Yamaguchi Kakuhiro , Tanahashi Hiroki , Kurose Koji , Sakamoto Shinjiro , Horimasu Yasushi , Masuda Takeshi , Nakashima Taku , Iwamoto Hiroshi , Hamada Hironobu , Oga Toru , Oka Mikio , Hattori Noboru 
Published: January 2025

Abstract

Background
The expression of anti-programmed cell death ligand-1 (PD-L1) in tumors is widely used as a biomarker to predict the therapeutic efficacy of anti-programmed cell death-1(PD-1)/PD-L1 antibodies. However, the predictive accuracy of this method is limited. High-mobility group box 1 (HMGB1) is known to modulate cancer immunity. Therefore, we investigated the potential of circulatory HMGB1 in combination with PD-L1 expression to predict the efficacy of anti-PD-1/PD-L1 antibody monotherapy.

Patients and methods
This multicenter retrospective study analyzed blood samples collected from 114 patients with non-small cell lung cancer (NSCLC) prior to anti-PD-1/PD-L1 antibody monotherapy at two university hospitals (Hiroshima University Hospital and Kawasaki Medical School Hospital) between December 2015 and October 2020. We evaluated the association of serum HMGB1 levels with tumor response and progression-free survival (PFS).

Results
Serum HMGB1 levels were significantly higher in patients with complete or partial response than in those with stable or progressive disease. Using receiver operating characteristic analysis, the cut-off level of serum HMGB1 to predict tumor response was determined to be 3.83 ng/mL. PFS was significantly longer in the HMGB1high group than that in the HMGB1low group in the entire cohort (4.3 months vs. 2.3 months) and in patients with NSCLC with PD-L1 tumor proportion score (TPS) ≥ 50% (12.4 months vs. 4.4 months), but not in those with PD-L1 TPS < 50% or unknown.

Conclusion
HMGB1 may serve as a predictive biomarker for the efficacy of anti-PD-1/PD-L1 antibody therapy in the patients with NSCLC, especially in those with PD-L1 TPS ≥ 50%.
Transurethral resection of the prostate across continents: a meta-analysis evaluating quality of gold standard in the twenty-first century
Authors: Porto Joao G. , Bhatia Ansh M. , Bhat Abhishek , Suarez Arbelaez Maria Camila , Blachman-Braun Ruben , Shah Khushi , Malpani Ankur , Lopategui Diana , Herrmann Thomas R. W. , Marcovich Robert , Shah Hemendra N. 
Published: January 2025

Abstract

Purpose
To compare outcomes of transurethral resection of the prostate (TURP) across different regions worldwide over the past two decades.

Methods
A systematic review and meta-analysis of randomized clinical trials indexed to PubMed that assessed TURP. A total of 102 studies with 8,454 patients were included and grouped by continents: Europe, Asia, Africa, and Others (North America, South America, and Australia). International Prostate Symptom Score (IPSS), peak flow (Qmax), postvoid residual urine (PVR), PSA levels, prostate volume, and Sexual Health Inventory for Men scores (at 3, 12, and 36 months) were assessed, along with postoperative complications. Heterogeneity across studies was classified as low (I2 < 25%), moderate (I2 = 25–75%), or high (I2 > 75%).

Results
TURP consistently exhibited significant enhancements in IPSS, Qmax, and PVR across various regions. Notably, PVR demonstrated high heterogeneity (I²=100%). TURP presented low complication rates with TURP syndrome (2%), bleeding (8%), and blood transfusion (6%). However, significant heterogeneity was observed, particularly for clot evacuation (I2 = 87%), irritative symptoms (I2 = 96%), and incontinence (I2 = 84%). The retreatment rates at 1 and 3 years were 5% and 7%, respectively, with significant differences across regions.

Conclusion
Global outcomes of TURP lack a discernible trend. The substantial heterogeneity observed among continents suggests a lack of standardization. Nevertheless, uniform symptomatic improvements among patients still support TURP as the gold-standard surgical treatment for benign prostatic hyperplasia, despite variations in its results worldwide.
Enlargement of the human prefrontal cortex and brain mentalizing network: anatomically homogenous cross-species brain transformation
Authors: Amano Hideki , Tanabe Hiroki C. , Ogihara Naomichi 
Published: January 2025

Abstract
To achieve a better understanding of the evolution of the large brain in humans, a comparative analysis of species differences in the brains of extant primate species is crucial, as it allows direct comparisons of the brains. We developed a method to achieve anatomically precise region-to-region homologous brain transformations across species using computational neuroanatomy. Utilizing three-dimensional neuroimaging data from humans (Homo sapiens), chimpanzees (Pan troglodytes), and Japanese macaques (Macaca fuscata), along with the anatomical labels of their respective brains, we aimed to create a cross-species average template brain that preserves neuroanatomical correspondence across species. Homologous transformation of the brain from one species to another can be computed using the cross-species average brain. Applying this transformation to human and chimpanzee brains revealed that, compared to chimpanzees, humans had significantly larger and more expanded prefrontal cortex, middle and posterior temporal gyrus, angular gyrus, precuneus, and cortical areas associated with mentalization. This neuroanatomically homologous brain transformation enables the systematic investigation of the similarities and differences in brain anatomy and structure across different species.
Fast and fair randomized wait-free locks
Authors: Ben-David Naama , Blelloch Guy E. 
Published: January 2025

Abstract
We present a randomized approach for wait-free locks with strong bounds on time and fairness in a context in which any process can be arbitrarily delayed. Our approach supports a tryLock operation that is given a set of locks, and code to run when all the locks are acquired. A tryLock operation may fail if there is contention on the locks, in which case the code is not run. Given an upper bound

$$\kappa $$

κ

known to the algorithm on the point contention of any lock, and an upper bound L on the number of locks in a tryLock’s set, a tryLock will succeed in acquiring its locks and running the code with probability at least

$$1/(\kappa L)$$

1
/
(
κ
L
)

. It is thus fair. Furthermore, if the maximum step complexity for the code in any lock is T, the operation will take

$$O(\kappa ^2 L^2 T)$$

O
(

κ
2

L
2

T
)

steps, regardless of whether it succeeds or fails. The operations are independent, thus if the tryLock is repeatedly retried on failure, it will succeed in

$$O(\kappa ^3 L^3 T)$$

O
(

κ
3

L
3

T
)

expected steps. If the algorithm does not know the bounds

$$\kappa $$

κ

and L, we present a variant that can guarantee a probability of at least

$$1/\kappa L\log (\kappa L T)$$

1
/
κ
L
log
(
κ
L
T
)

of success. We assume an oblivious adversarial scheduler, which does not make decisions based on the operations, but can predetermine any schedule for the processes, which is unknown to our algorithm. Furthermore, to account for applications that change their future requests based on the results of previous tryLock operations, we strengthen the adversary by allowing decisions of the start times and lock sets of tryLock operations to be made adaptively, given the history of the execution so far.
Elevated A2F bisect N-glycans of serum IgA reflect progression of liver fibrosis in patients with MASLD
Authors: Hanamatsu Hisatoshi , Suda Goki , Ohara Masatsugu , Ogawa Koji , Tamaki Nobuharu , Hikita Hayato , Haga Hiroaki , Maekawa Shinya , Sugiyama Masaya , Kakisaka Tatsuhiko , Nakai Masato , Sho Takuya , Miura Nobuaki , Kurosaki Masayuki , Asahina Yasuhiro , Taketomi Akinobu , Ueno Yoshiyuki , Takehara Tetsuo , Nishikaze Takashi , Furukawa Jun-ichi , Sakamoto Naoya 
Published: January 2025

Abstract

Background
Advanced liver fibrosis in cases of metabolic dysfunction-associated steatotic liver disease (MASLD) leads to cirrhosis and hepatocellular carcinoma. The current gold standard for liver fibrosis is invasive liver biopsy. Therefore, a less invasive biomarker that accurately reflects the stage of liver fibrosis is highly desirable.

Methods
This study enrolled 269 patients with liver biopsy-proven MASLD. Patients were divided into three groups (F0/1 (n = 41/85), F2 (n = 47), and F3/4 (n = 72/24)) according to fibrosis stage. We performed serum N-glycomics and identified glycan biomarker for fibrosis stage. Moreover, we explored the carrier proteins and developed a sandwich ELISA to measure N-glycosylation changes of carrier protein.

Results
Comprehensive N-glycomic analysis revealed significant changes in the expression of A2F bisect and its precursors as fibrosis progressed. The sum of neutral N-glycans carrying bisecting GlcNAc and core Fuc (neutral sum) had a better diagnostic performance to evaluate advanced liver fibrosis (AUC = 0.804) than conventional parameters (FIB4 index, aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), and serum level of Mac-2-binding protein glycol isomer (M2BPGi). The combination of the neutral sum and FIB4 index enhanced diagnostic performance (AUC = 0.840). IgM, IgA, and complement C3 were identified as carrier proteins with A2F bisect N-glycan. A sandwich ELISA based on N-glycans carrying bisecting GlcNAc and IgA showed similar diagnostic performance than the neutral sum.

Conclusions
A2F bisect N-glycan and its precursors are promising candidate biomarkers for advanced fibrosis in MASLD patients. Analysis of these glycan alterations on IgA may have the potential to serve as a novel ELISA diagnostic tool for MASLD in routine clinical practice.

Clinical trial number
UMIN000030720.
Emotion processing difficulties in ADHD: a Bayesian meta-analysis study
Authors: Soler-Gutiérrez Ana-María , Sánchez-Carmona Alberto J. , Albert Jacobo , Hinojosa José Antonio , Cortese Samuele , Bellato Alessio , Mayas Julia 
Published: January 2025

Abstract
We investigated whether there is an emotional processing deficit in ADHD and whether this only applies to specific emotional categories. In this PRISMA-compliant systematic review based on a pre-registered protocol (https://osf.io/egp7d), we searched MEDLINE, PsycINFO, ERIC, Scopus and Web of Science databases until 3rd December 2023, to identify empirical studies comparing emotional processing in individuals meeting DSM (version III to 5-TR) or ICD (version 9 or 10) criteria for Attention Deficit/Hyperactivity Disorder (ADHD) and in a non-psychiatric control group. Study quality was assessed with the Appraisal tool for Cross-Sectional Studies (AXIS). Eighty studies were included and meta-analysed (encompassing 6191 participants and 465 observations). Bayesian meta-analyses were conducted to compare individuals with ADHD and non-psychiatric controls on overall emotional processing measures (meta-analysis 1) and across emotional categories (meta-analysis 2). The type of stimulus employed, outcome measurement reported, age, sex, and medication status were analysed as moderators. We found poorer performance in both overall emotion processing (g =  − 0.65) and across emotional categories (anger g =  − 0.37; disgust g =  − 0.24; fear g =  − 0.37; sadness g =  − 0.34; surprise g =  − 0.26; happiness/positive g =  − 0.31; negative g =  − 0.20; neutral g =  − 0.25) for individuals with ADHD compared to non-psychiatric controls. Scales items and accuracy outcome being the most effective moderators in detecting such differences. No effects of age, sex, or medication status were found. Overall, these results show that impaired emotional processing is a relevant feature of ADHD and suggest that it should be systematically assessed in clinical practice.