bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binjai Train Ticket Counter Queue Simulation Using Weibull Service Distribution
Authors: Agtalia Refirda , Akim M H Pardede  , Magdalena Simanjuntak  
Published: October 2023

This research aims to improve the efficiency of train ticket counter services at Binjai Station through the use of Weibull service distribution-based queuing simulations. Long queues and excessive waiting times are often problems at many train stations, and this research aims to address these problems.This study collects queuing data from train ticket booths at Binjai Station over a certain period and analyzes them to identify existing queuing patterns. The Weibull service distribution was chosen as the appropriate model to describe the ticket counter service time, because this distribution has the flexibility to handle variations in service time well.

Queue simulation is carried out using simulation software that models the queuing process at the train ticket counter. Weibull distribution parameters are integrated into the simulation to predict service time at the ticket counter. In this simulation, various scenarios and strategies for improving service efficiency are evaluated to identify the best alternative that can be implemented at Binjai Station. The results of this study will provide guidance to the management of the Binjai train station in making decisions regarding increasing the efficiency of ticket counter services. By optimizing service time and reducing customer waiting time, it is expected to increase customer satisfaction and operational efficiency of train stations.
El Grupo Parlamentario Mixto de la Asamblea de Madrid
Authors: Arévalo Gutiérrez Alfonso 
Published: October 2023

La normativa reguladora de los Grupos Parlamentarios de la Asamblea de Madrid —ex artículos 13.2 del Estatuto de Autonomía y 40, 42, 43.2 y 3, 44 y 45 del Reglamento de la Cámara— no contempla la posibilidad de que un miembro de la misma no esté integrado en una formación parlamentaria, es decir, lo que se conoce en otras Asambleas Legislativas con la denominación de “Diputado no adscrito”.
El Reglamento de la Asamblea dispone, en efecto, que los Grupos Parlamentarios deben constituirse dentro de los cinco días siguientes a la sesión constitutiva de la Cámara, de tal modo que los Diputados que no se integren en ninguna formación dentro de dicho plazo se incorporarán, de forma automática y ope legis, en el denominado Grupo Mixto durante todo el tiempo que reste de Legislatura.
Con dicho presupuesto normativo, de las ocho Legislaturas que ha visto nacer la Asamblea de Madrid cuatro han contemplado la constitución de un Grupo Mixto: la I (1983-1987), la II (1987-1991), la IV (1995-1999) y la efímera VI (2003).
En la I, II y IV Legislaturas la constitución del referido Grupo no lo fue ab origine, es decir, al inicio de la Legislatura, sino durante su desarrollo y como consecuencia de migraciones parlamentarias propias del denominado “transfugismo político”.
Nuevos roles de los Parlamentos autonómicos en la integración europea tras las reformas estatutarias
Authors: Guillem Carrau Javier 
Published: October 2023

El proceso de integración comunitario adolece, junto a cierto desconocimiento del hecho regional de gran parte de los Estados miembros, de la falta de participación de los Parlamentos regionales.
En nuestro ámbito, los Parlamentos autonómicos no han sido tradicionalmente una referencia de debate o decisión ni en el marco de la llamada fase ascendente de este proceso, ni en el de la descendente.
En estas líneas, se recogen algunas reflexiones sobre el lugar de los mismos en el marco de las cuestiones de la UE ante los nuevos retos que plantean las recientes reformas estatutarias y reglamentarias.
Effect of the index of cardiac electrophysiological balance on major adverse cardiovascular events in patients with diabetes complicated with coronary heart disease
Authors: Lin Yuan , Zhou Fang , Wang Xihui , Guo Yaju , Chen Weiguo 
Published: October 2023

Purpose
To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease.

Methods
A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF), and sudden cardiac arrest (SCA). Patients were followed for a median period of 3.26 years, and the associations between ICEB levels and various outcomes were evaluated.

Results
Over the follow-up period, 46 (5.0%) MACE were observed in the normal ICEB group, 57 (6.2%) in the low ICEB group, and 62 (6.8%) in the high ICEB group. Elevated ICEB levels were found to be associated with a higher risk of MACE and cardiovascular death. A significant relationship between ICEB levels and the risk of MACE was observed for both genders. The risk of MACE increased with each unit increment in the ICEB index. However, the two-stage linear regression model did not outperform the single-line linear regression models in determining the threshold effect.

Conclusion
This study demonstrates the potential utility of ICEB, derived from a standard non-invasive ECG, as a prognostic tool for predicting MACE and cardiovascular death in diabetic patients complicated with CVD. The associations between ICEB levels and the risk of MACE highlight the importance of understanding cardiac electrophysiological imbalances and their implications in CVD.
Analysis of factors influencing the pathological complete remission (ipCR) in patients with internal mammary lymph node metastasis after neoadjuvant chemotherapy
Authors: Li Yang , Fei Yang 
Published: October 2023

Objective
To investigate the factors impacting pathological complete remission (ipCR) of the internal mammary lymph nodes in patients with internal mammary lymph node metastasis (IMLN) after adjuvant chemotherapy.

Methods
Sixty-five cases of primary breast cancer (BC) with IMLN metastasis who had received neoadjuvant chemotherapy (NAC) were retrospectively analyzed. Postoperative pathology was used to divide the patients into ipCR and non-ipCR groups. Univariate and multivariate analyses were performed on ipCR after NAC. A receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the factors related to ipCR and a Kaplan-Meier curve was used to analyze prognosis.

Results
Twenty-nine (44.62%) of the 65 female patients received ipCR after NAC. Significant differences in hormone receptor (HR) negative and axillary pathological complete response (apCR) rates between the ipCR and non-ipCR group (P < 0.05). Multivariate logistic regression analysis showed that HR (OR = 2.698) and apCR (OR = 4.546) were the most significant factors that influenced ipCR (P < 0.05). The ROC curves showed that the area under the curves (AUC) for HR and apCR for the prediction of ipCR were 0.744 and 0.735 respectively. The AUC for the combined detection was 0.905. The average disease free survival (DFS) for patients in the ipCR group was 94.0 months which was significantly longer compared to patients in the non-ipCR group (64.2 months) (χ2 = 4.265, P = 0.039). No significant difference in OS was detected between the two groups (P > 0.05).

Conclusions
ipCR after NAC is correlated with HR and apCR. HR combined with apCR has value in predicting ipCR. ipCR has prognostic value in patients with IMLN metastasis and may have the potential to inform clinical decision-making. Further validation of these findings is required through larger-scale prospective studies.
KSFinder—a knowledge graph model for link prediction of novel phosphorylated substrates of kinases
Authors: Anandakrishnan Manju , Ross Karen E. , Chen Chuming , Shanker Vijay , Cowart Julie , Wu Cathy H. 
Published: October 2023

Background
Aberrant protein kinase regulation leading to abnormal substrate phosphorylation is associated with several human diseases. Despite the promise of therapies targeting kinases, many human kinases remain understudied. Most existing computational tools predicting phosphorylation cover less than 50% of known human kinases. They utilize local feature selection based on protein sequences, motifs, domains, structures, and/or functions, and do not consider the heterogeneous relationships of the proteins. In this work, we present KSFinder, a tool that predicts kinase-substrate links by capturing the inherent association of proteins in a network comprising 85% of the known human kinases. We also postulate the potential role of two understudied kinases based on their substrate predictions from KSFinder.

Methods
KSFinder learns the semantic relationships in a phosphoproteome knowledge graph using a knowledge graph embedding algorithm and represents the nodes in low-dimensional vectors. A multilayer perceptron (MLP) classifier is trained to discern kinase-substrate links using the embedded vectors. KSFinder uses a strategic negative generation approach that eliminates biases in entity representation and combines data from experimentally validated non-interacting protein pairs, proteins from different subcellular locations, and random sampling. We assess KSFinder’s generalization capability on four different datasets and compare its performance with other state-of-the-art prediction models. We employ KSFinder to predict substrates of 68 “dark” kinases considered understudied by the Illuminating the Druggable Genome program and use our text-mining tool, RLIMS-P along with manual curation, to search for literature evidence for the predictions. In a case study, we performed functional enrichment analysis for two dark kinases - HIPK3 and CAMKK1 using their predicted substrates.

Results
KSFinder shows improved performance over other kinase-substrate prediction models and generalized prediction ability on different datasets. We identified literature evidence for 17 novel predictions involving an understudied kinase. All of these 17 predictions had a probability score ≥0.7 (nine at >0.9, six at 0.8–0.9, and two at 0.7–0.8). The evaluation of 93,593 negative predictions (probability ≤0.3) identified four false negatives. The top enriched biological processes of HIPK3 substrates relate to the regulation of extracellular matrix and epigenetic gene expression, while CAMKK1 substrates include lipid storage regulation and glucose homeostasis.

Conclusions
KSFinder outperforms the current kinase-substrate prediction tools with higher kinase coverage. The strategically developed negatives provide a superior generalization ability for KSFinder. We predicted substrates of 432 kinases, 68 of which are understudied, and hypothesized the potential functions of two dark kinases using their predicted substrates.
Fluoride Levels in Borehole Water: The Case of Chiradzulu District in Malawi
Authors: Wesley Yohane A. , Njewa Joel B. , Makawa Kelvin , Maurice Stanley , Moteni Esinta , Majamanda James , Chirambo Lloyd , Chimphepo Lifa 
Published: October 2023

Aims: The objective of this study was to determine the levels of fluoride in borehole water samples.
Study Design: The total of eight samples were collected from five villages in Chiradzulu and transported in cooler ice-bath to the laboratory for the analysis.
Place and Duration of Study: The study was conducted in the Department of Chemistry and Chemical Engineering Laboratories, at University of Malawi in the month of June.
Methodology: The ion selective electrode technique was used to assess fluoride levels. Physicochemical water parameters were measured with multi-meters.
Results: The results obtained ranged from 2.26 to 3.08 mg/L, 136 to 561 mg/L, 261-1212 μs/cm and 6.27 to 6.97, for Fluorides, TDS, conductivity and pH, respectively. Levels of fluorides exceeded permissible limits for borehole water established by WHO and were below the standards for MBS
Conclusion: The results attained in the scope of the study support coloration of teeth observed amongst individuals in study communities, helping to understand that groundwater is not suitable for consumption. Therefore, the study provides recommendation for urgent implementation of defluoridation measures to provide clean and safe water for the existing community members.
Production of Copper Nanoparticles by Aspergillus niger and Evaluation of their Biomedical Applications
Authors: Hussain Syed Bilal , Aslam Maria , Aslam Asad , Noor Sadaf , Zubair Muhammad 
Published: October 2023

Nanotechnology is a well advanced area and different types of nanoparticles are now produced. The most revolutionary topic of the twenty-first century is nanotechnology. Recently, metallic nanoparticles (NPs) have gained a lot of attention. In this study a straightforward, safe, and economical method is used for synthesizing copper nanoparticles (CuNPs) by using cell free filtrate of Aspergillus niger. Fungi secretes enormous amount of enzymes which act as reducing as well stabilizing agents. Synthesized CuNPs were characterized by different techniques. Ultraviolet (UV)-visible spectrophotometer showed a characteristic peak at 380nm, Dynamic Light Scattering (DLS) analysis indicated that CuNPs have average size of 570nm with 0.480 PDI. SEM (Scanning Electron Microscopy) revealed CuNPs are of cubic shape. As per FTIR (Fourier Transform Infrared Analysis) two functional groups i.e., -O-H- and C=C- on the surface of CuNPs. Genetic analysis of Aspergillus niger revealed the presence of nitrate reductase enzyme that may involve in reduction of metal into NPs. Furthermore, CuNPs showed significant antibacterial action against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Klebsiella pneumoniae with 17mm, 20mm, 17mm and 20mm respectively. CuNPs also showed antioxidant potential with 59.41µg/ml.
Fungi secretes valuable enzymes with inherent ability to reduce metal ions into NPs. This reduced the cost of NPs synthesis and also synthesized NPs exhibit greater biomedical applications.
Study on the Correlation of Insect Pest Infestation of Guinea Corn (Sorghum bicolor) Stored in Kasarawa and Kuffa Food Ware-Houses in Sokoto Metropolis, Sokoto State, Nigeria
Authors: Lema S. Y. , Ibrahim J. , Suleiman J. 
Published: October 2023

Farming of Guinea corn in Sokoto is face with a lot of Crop protection problems which prevent full scale production of this crop in the state and Nigeria at large. A study was conducted to assess the correlation of insect pest infestation of Guinea corn stored in Kasarawa and Kuffa Food Ware-houses in Sokoto Metropolis Sokoto State-Nigeria. A total of Two Hundred and Fourty (240) grain samples were collected and examined for insect pest infestation using compound microscope and the result was analyzed using Chi-square statistical tool. The result of this study showed that 172/240 (71.67%) were positive for insect pest infestation. There were significance difference between the infestation and nature of the food ware-house (P<0.05). The result of infestation in relation to the location were the samples are collected from the food ware-houses shows that, top location 71/80 (88.75%) has the highest rate of the Infestation, followed by the middle location 53/80 (66.25%) and the least Infestation was recorded in the bottom location of the food ware-houses 30/80 (37.50%). There is also a significance difference between the infestation and locations where the samples are collected from the food ware-house (P<0.05). Of the two species identified, Tribolium confusum is found in all the three food ware-houses with the frequency of 0.7 and 0.6 respectively while Tribolium casteneum was found only in Kuffa/Old Kara food ware-house with the frequency of 0.2. This may be related to the nature of food ware-houses. Used of resistance varieties, Improve sanitation, proper maintenance and fumigation of the food ware-house in and out during storage and while receiving new produce will help to reduce the rate of insect pest infestation in the study area, Sokoto State and Nigeria at large.
Effect of Organic Sources and Fertilizer Levels on Physiological Response of Garlic by Using Infrared Gas Analysis (IRGA) in Western Rajasthan, India
Authors: Kumawat Suresh , Yadav S. R. , Rathore R. S. , Sharma B. D. , Kumawat Sumitra 
Published: October 2023

Crop growth and yields are negatively affected by sub-optimal water supply and abnormal temperatures due to physical damages, physiological disruptions, and biochemical changes. A better understanding of garlic responses to organic and inorganic sources conducted A two years field experiment was conducted at Agricultural Research Farm, SKRAU, Bikaner during Rabi 2020-21 and 2021-22. The experiment comprising total 32 treatment combinations; eight sources of organic materials (Control (M0), FYM @ 20 t ha-1 (M1), Groundnut husk (GNH) @ 20 t ha-1 (M2), Wool waste (WW) @ 20 t ha-1 (M3), FYM @ 10 tha-1 + GNH @ 10 t ha-1 (M4), WW @ 10 t ha-1 + GNH @ 10 t ha-1 (M5), WW @ 10 t ha-1 + FYM @ 10 t ha-1 (M6), WW @ 6.67 t ha-1 + FYM @ 6.67 t ha-1 + GNH @ 6.67 t ha-1 (M7) and four fertilizer levels (Control (F0), 50% RDF (F1), 75% RDF (F2) and 100% RDF (F3) in split plot design with three replications. Result indicated that maximum improvement in photosynthetic rate was recorded under the wool waste applied @ 20 t ha-1 with 100% recommended dose of fertilizer.
Causes and Strategies for Reducing Road Traffic Accidents in the Bongo District of Ghana
Authors: Agebure Andrews Baba , Amedorme Sherry Kwabla , Johnson Amoanab Norbert 
Published: October 2023

Aim: This study intends to assess drivers’ state of knowledge on the main causes and the best strategies capable of reducing road traffic accidents in the Bongo District of Ghana.
Study Design: The study was a descriptive design.
Place and Duration of Study: The study was conducted in the Bongo District of the Upper East Region of Ghana between July 2023 and August 2023.
Methodology: The researcher conducted a survey involving 100 drivers who were randomly selected from a driver population of 120 in the Bongo District. The data were analyzed using Microsoft Excel [Version 19]. The results of the data analysis were presented as tables and charts.
Results: The study found that the main causes of road traffic accidents emanate from human error such as low driving skills, excessive speeding, and poor vision of driver. Also, road conditions like bad road networks, no lane markings, and no speed limit signs were found as causal factors of road traffic accidents. Faulty vehicles with causative factors such as defective tyres, brakes, and lights were noted to be also responsible for road accidents. Nevertheless, the least factor was environmental conditions such as bad weather conditions and stray animals being enumerable as environmental conditions which cause road accidents. The study further found that the best strategies for curbing road traffic accidents were enforcement of traffic laws, education and training of drivers, obeying traffic rules by drivers, and maintaining vehicles well.
Conclusion: The study, therefore, concluded that human factors play a central role in contributing to road accidents and curbing road traffic accidents. The research findings can be used to guide stakeholders in formulating and prioritizing interventions that are more human-centred for the curbing of road traffic accidents in the Bongo District of Ghana.
Website User Behavior at the Semarang Health Data Repository - Udinus Campus (SEHARIKU)
Authors: Haikal  , Yuantari M. G. Catur , Rachmani Enny , Ariyanto Amelia Devi Putri , Prasetya Jaka , Isworo Slamet 
Published: October 2023

Background and Objectives: Efforts to use data to aid decision-making have not yet realized their full potential. The Faculty of Health, Dian Nuswantoro University (Udinus), has launched Semarang Health Data Repository - Udinus Campus (SEHARIKU) as a health data storage website in Semarang City. However, the public's use of SEHARIKU remains restricted, probably due to a variety of causes such as a lack of awareness of the presence of this site, a lack of information available on it, or features that are not optimal. The purpose of this study is to investigate user behavior on data storage websites.
Methods: This research uses a user study approach with a descriptive research design using an online survey of SEhariku website users. The survey contains a series of questions regarding user behavior when using the SEHARIKU site, for 83 users on the SEHARIKU website.
Results: The research results show that the majority of users have a low frequency of use, of which 51.8% of them 'rarely' access the SEHARIKU website, but the majority of respondents consider the search feature easy to use. Satisfaction with the graphic visualization features in SEhariku is high, with 92.3% of respondents stating they were satisfied or very satisfied. The majority of users also found the platform convenient for finding the data they needed, with 80.7% finding their searches easy. To increase the use and benefits of SEHARIKU, and overcome the low frequency of use, it is necessary to improve existing features such as the search feature, and intensify promotional efforts along with increasing awareness about the benefits of the website.
Suggestion: Motivating users to actively provide input and recommendations for future development of SEHARIKU is very important.
Vibration Suppression and Adaptive Fault‐Tolerant Control for Three‐Dimensional Flexible Rotating Manipulator With Input Signal Constraints
Authors: Wang Jiacheng , Zhang Qingzhen , Liu Jinkun , Chen Xing , Xue Cenbo 
Published: January 2025

ABSTRACTBased on a three‐dimensional flexible, rotating manipulator, this paper is dedicated to the issue of vibration suppression and angle planning subject to actuator failures and input signal constraints. Considering that a flexible link belongs to a distributed parameter system, the motion model is obtained by Hamilton's principle and described by partial differential equations (PDEs). A novel fault‐tolerant control law is proposed to eliminate the elastic deflection and vibration of the flexible link and to follow the desired angle of the rotating base and the manipulator with the appearance of actuator failures. The adaptive operator based on projection mapping is adopted to estimate the loss of the actuator. In addition, the hyperbolic tangent function is employed to constrain the input signal so that it is within an adjustable interval. The Lyapunov's method and LaSalle invariance principle are applied to prove the stability and convergence of the closed‐loop system. The simulation results are provided to demonstrate the effectiveness of the proposed method.
Dissipative Synchronization Control for Two‐Time‐Scale Markov Jump Neural Networks Subject to Redundant Channels: A Hidden‐Markov‐Model‐Based Method
Authors: Wang Yongqian , Ni Zhenghao , Wang Kang , Li Feng , Shen Hao 
Published: January 2025

ABSTRACTThis work studies the synchronization issue for two‐time‐scale Markov jump neural networks subject to redundant channels. In such systems, mode information may not be directly available (e.g., packet loss), and traditional synchronous control methods cannot meet this challenge. The hidden Markov model can deal with the situation that the systems state cannot be accessed directly, and estimate the current state of the system through the “observation” mode, so as to improve the controller design and advance the stability and robustness of the systems. Therefore, the controller is designed based on a hidden Markov model for the above scenarios. Meanwhile, the redundant channels are built to reduce the influence of packet loss. Moreover, the two‐time‐scale phenomenon of the plant is considered by using the singular perturbation parameter. Then, the Lyapunov function construction is associated with the singular perturbation parameter and some sufficient conditions to guarantee the stability of the plant are obtained. Finally, the designed control law is available which is demonstrated by two illustrative examples.