bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Cationic Hyperbranched Polyaminoglycosides that Target Multiple Mediators for Severe Abdominal Trauma Management
Authors: Xiao Yongqiang , Fang He , Zhu Yuefei , Zhou Jie , Dai Zhanzhan , Wang Hongxia , Xia Zhaofan , Tu Zhaoxu , Leong Kam W. 
Published: November 2023

AbstractTrauma and its associated complications, including dysregulated inflammatory responses, severe infection, and disseminated intravascular coagulation (DIC), continue to pose lethal threats worldwide. Following injury, cell‐free nucleic acids (cfNAs), categorized as damage‐associated molecular patterns (DAMPs), are released from dying or dead cells, triggering local and systemic inflammatory responses and coagulation abnormalities that worsen disease progression. Harnessing cfNA scavenging strategies with biomaterials has emerged as a promising approach for treating posttrauma systemic inflammation. In this study, the effectiveness of cationic hyperbranched polyaminoglycosides derived from tobramycin (HPT) and disulfide‐included HPT (ss‐HPT) in scavenging cfNAs to mitigate posttrauma inflammation and hypercoagulation is investigated. Both cationic polymers demonstrate the ability to suppress DAMP‐induced toll‐like receptor (TLR) activation, inflammatory cytokine secretion, and hypercoagulation by efficiently scavenging cfNAs. Additionally, HPT and ss‐HPT exhibit potent antibacterial efficacy attributed to the presence of tobramycin in their chemical composition. Furthermore, HPT and ss‐HPT exhibit favorable modulatory effects on inflammation and therapeutic outcomes in a cecal ligation puncture (CLP) mouse abdominal trauma model. Notably, in vivo studies reveal that ss‐HPT displayed high accumulation and retention in injured organs of traumatized mice while maintaining a higher biodegradation rate in healthy mice, contrasting with findings for HPT. Thus, functionalized ss‐HPT, a bioreducible polyaminoglycoside, holds promise as an effective option to enhance therapeutic outcomes for trauma patients by alleviating posttrauma inflammation and coagulation complications.
Spider‐Silk‐Inspired Tough, Self‐Healing, and Melt‐Spinnable Ionogels
Authors: Sun Lijie , Huang Hongfei , Zhang Luzhi , Neisiany Rasoul Esmaeely , Ma Xiaopeng , Tan Hui , You Zhengwei 
Published: November 2023

AbstractAs stretchable conductive materials, ionogels have gained increasing attention. However, it still remains crucial to integrate multiple functions including mechanically robust, room temperature self‐healing capacity, facile processing, and recyclability into an ionogel‐based device with high potential for applications such as soft robots, electronic skins, and wearable electronics. Herein, inspired by the structure of spider silk, a multilevel hydrogen bonding strategy to effectively produce multi‐functional ionogels is proposed with a combination of the desirable properties. The ionogels are synthesized based on N‐isopropylacrylamide (NIPAM), N, N‐dimethylacrylamide (DMA), and ionic liquids (ILs) 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMI][TFSI]). The synergistic hydrogen bonding interactions between PNIPAM chains, PDMA chains, and ILs endow the ionogels with improved mechanical strength along with fast self‐healing ability at ambient conditions. Furthermore, the synthesized ionogels show great capability for the continuous fabrication of the ionogel‐based fibers using the melt‐spinning process. The ionogel fibers exhibit spider‐silk‐like features with hysteresis behavior, indicating their excellent energy dissipation performance. Moreover, an interwoven network of ionogel fibers with strain and thermal sensing performance can accurately sense the location of objects. In addition, the ionogels show great recyclability and processability into different shapes using 3D printing. This work provides a new strategy to design superior ionogels for diverse applications.
Mechanical Intercellular Communication via Matrix‐Borne Cell Force Transmission During Vascular Network Formation
Authors: Davidson Christopher D. , Midekssa Firaol S. , DePalma Samuel J. , Kamen Jordan L. , Wang William Y. , Jayco Danica Kristen P. , Wieger Megan E. , Baker Brendon M. 
Published: November 2023

AbstractIntercellular communication is critical to the formation and homeostatic function of all tissues. Previous work has shown that cells can communicate mechanically via the transmission of cell‐generated forces through their surrounding extracellular matrix, but this process is not well understood. Here, mechanically defined, synthetic electrospun fibrous matrices are utilized in conjunction with a microfabrication‐based cell patterning approach to examine mechanical intercellular communication (MIC) between endothelial cells (ECs) during their assembly into interconnected multicellular networks. It is found that cell force‐mediated matrix displacements in deformable fibrous matrices underly directional extension and migration of neighboring ECs toward each other prior to the formation of stable cell‐cell connections enriched with vascular endothelial cadherin (VE‐cadherin). A critical role is also identified for calcium signaling mediated by focal adhesion kinase and mechanosensitive ion channels in MIC that extends to multicellular assembly of 3D vessel‐like networks when ECs are embedded within fibrin hydrogels. These results illustrate a role for cell‐generated forces and ECM mechanical properties in multicellular assembly of capillary‐like EC networks and motivates the design of biomaterials that promote MIC for vascular tissue engineering.
Challenges hindering emergency physicians; involvement in multicenter collaborative studies in Japan: A nationwide survey analysis
Authors: Yasuda Manaho , Saito Ayaka , Goto Tadahiro , Yamamoto Ryohei , Liu Keibun , Kuriyama Akira , Kondo Yutaka , Kasugai Daisuke ,   RED‐PAM study investigators
Published: November 2023

AbstractAimMulticenter collaborative research accelerates patient recruitment and strengthens evidence. Nevertheless, the factors influencing emergency and critical care physicians’ involvement in such research in Japan remain unclear.MethodsA nationwide web‐based survey conducted in early 2023 targeted emergency physicians working a minimum of 3 days per week in Japan. The survey descriptively assessed their backgrounds, work and research environments, experiences, and perceived impediments and motivators for multicenter research.ResultsOf the 387 respondents, 348 were included in the study, yielding a 5.1% response rate. Women comprised 11% of the participants; 33% worked in university hospitals, 65% served in both emergency departments and intensive care units, and 54% did shift work. Only 12% had designated research time during working hours, with a median of 1 hour per week (interquartile range 0–5 h), including time outside of work. While 73% had participated in multicenter research, 58% noted barriers to participation. The key obstacles were excessive data entry (72%), meeting time constraints (59%), ethical review at each facility (50%), and unique sample collection, such as bronchoalveolar lavage specimens or pathological tissues (51%). The major incentives were networking (70%), data sets reuse (65%), feedback on research results (63%), and recognition from academic societies (63%). Financial rewards were not highly prioritized (38%).ConclusionsWhile valuing clinical research, emergency physicians face barriers, especially data entry burden and limited research time. Networking and sharing research findings motivate them. These insights can guide strategies to enhance collaborative research in emergency and critical care in Japan.
Altered Impulsivity Across Drug‐Naïve Parkinsonism, Isolated Rapid Eye Movement Sleep Behavior Disorder, and Their High‐Risk Relatives
Authors: Zhou Li , Li Shirley Xin , Chau Steven WH , Huang Bei , Wang Jing , Tang Shi , Chan Joey WY , Zhang Jihui , Yu Mandy WM , Tsang Jessie CC , Hu Michele TM , Mok Vincent CT , Wing Yun Kwok , Liu Yaping 
Published: November 2023

ObjectiveTo determine multidimensional impulsivity levels across different early stages of α‐synucleinopathy.MethodsThis cross‐sectional study investigated motor and decisional impulsivity levels using a panel of computerized tasks among drug‐naïve parkinsonism patients, isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) patients and their first‐degree relatives (iRBD‐FDRs), and control participants. Trait impulsivity and impulse control behaviors were assessed by self‐reported questionnaires.ResultsA total of 27 drug‐naïve parkinsonism patients, 157 iRBD patients, 66 iRBD‐FDRs, and 82 control participants were recruited. Parkinsonism and iRBD patients had fewer numbers of extracted beads in beads task 1 and 2 (both p < 0.001), and a higher rate of irrational choice in task 1 (p = 0.046) before making decisions, and fewer numbers of pumps of unexploded blue balloons in the balloon analog risk task (p = 0.004) than control participants, indicating a higher level of reflection impulsivity and a lower level of risk taking, respectively. iRBD patients had more no‐go errors in the go/no‐go task than control participants (padjusted = 0.036), suggesting a higher level of motor impulsivity. iRBD‐FDRs with dream‐enactment behaviors had fewer numbers of extracted beads (p = 0.047) in beads task 2 than FDRs without dream‐enactment behaviors, suggesting a possible higher level of reflection impulsivity.InterpretationA complex construct of altered impulsivity with decreased risk taking, but increased reflection and motor impulsivity, has already occurred at the prodromal and early stages of α‐synucleinopathy, which have implications for underlying pathophysiology and clinical management of α‐synucleinopathy, especially for impulse control behaviors upon dopaminergic drug treatment. ANN NEUROL 2024;95:544–557
Discrimination of Turkish Gemlik virgin olive oils by growing regions and environmental conditions
Authors: Keceli Turkan Mutlu , Celik Fulya Harp 
Published: November 2023

AbstractGeographic origins together with environmental conditions (temperature, rainfall, humidity, altitude) during harvest, could alter the olive oil quality, nutritional value, and traceability. The impact of geographic region (Bursa PDO, Hatay, Mersin, and Izmir NPDO) and conditions at harvest years (2016 and 2017) on the quality and traceability of Gemlik virgin olive oils were investigated. Environmental conditions (high temperature and relative humidity, low rainfall) resulted in low quality due to increase in FFA, linoleic acid, PUFA, Δ7‐stigmastenol, stigmasterol and total sterols in oils obtained from southeast (Hatay and Mersin) NPDO regions. Bursa PDO and Izmir NPDO Gemlik virgin olive oils were high in oleic acid, MUFA, hydroxtytyrsol, tyrosol, antioxidant activity and, ∆5‐avenesterol and discriminated by 99% accuracy with discriminant analysis. PCA and DA can easily detect and distinguish differences in virgin olive oils quality and purity coming from different growing regions and subjected to inverse environmental conditions. Bursa PDO and Izmir NPDO growing regions have better conditions for Gemlik olives cultivation to obtain high quality and oxidative resistant Gemlik virgin olive oils.
A new deal for dynamic psychotherapies: The psychoanalyst as street‐level bureaucrat
Authors: Clarke Jeremy 
Published: November 2023

AbstractIn the UK in 2007 a national experiment was initiated with the aim of tackling “Britain's Biggest Social Problem”—Depression. Improving Access to Psychological Therapies (IAPT) was devised as the solution. A universal free‐to‐access talking therapies program would make available evidence‐based treatment to all adults with depression. NICE (National Institute for Health and Care Excellence), the body that decides on what is cost‐effective, said CBT, not antidepressants, should be its first line offer. The starting gun was fired. The promise from IAPT was 3‐fold: to scale up access to CBT rapidly; to achieve recovery targets that would reduce the prevalence of depression over time; and—most ambitious of all—to ensure the Treasury would see a return on its investment by reducing the economic burden from depression. People who were on invalidity benefits due to depression would be supported back into employment. It was a New Deal for depression. As well as for CBT. But did it work? A decade and a half on with IAPT, are we in any position to give an answer? This paper will seek to draw lessons about “What Worked”, and what didn't, to askourselvesa question: arewe—those of us in the applied psychoanalytic community—willing to garner what can be learned from IAPT to advocate a new deal for evidence‐based psychoanalysis? Faced with challenges from unemployment and widening inequalities, against a backdrop where global economic recovery must heed the existential threats from climate change and ongoing warfare, to say nothing of the scale of loss and grief for those already impacted by bereavement due to the pandemic, the need for some such deal could not be more urgent.
From academic to media capital: To what extent does the scientific reputation of universities translate into Wikipedia attention?
Authors: Arroyo‐Machado Wenceslao , Díaz‐Faes Adrián A. , Herrera‐Viedma Enrique , Costas Rodrigo 
Published: November 2023

AbstractUniversities face increasing demands to improve their visibility, public outreach, and online presence. There is a broad consensus that scientific reputation significantly increases the attention universities receive. However, in most cases estimates of scientific reputation are based on composite or weighted indicators and absolute positions in university rankings. In this study, we adopt a more granular approach to assessment of universities' scientific performance using a multidimensional set of indicators from the Leiden Ranking and testing their individual effects on university Wikipedia page views. We distinguish between international and local attention and find a positive association between research performance and Wikipedia attention which holds for regions and linguistic areas. Additional analysis shows that productivity, scientific impact, and international collaboration have a curvilinear effect on universities' Wikipedia attention. This finding suggests that there may be other factors than scientific reputation driving the general public's interest in universities. Our study adds to a growing stream of work which views altmetrics as tools to deepen science–society interactions rather than direct measures of impact and recognition of scientific outputs.
Modellbasierte Etagenlogistikplanung für die Ausbauphase im Hochbau – Teil 1: Erarbeitung des Konzepts
Authors: Jaster Isabell , Placzek Gerrit , Schwerdtner Patrick 
Published: November 2023

AbstractDie Baulogistik besitzt für Bauprojekte eine zentrale Bedeutung. Insbesondere in der Ausbauphase mehrgeschossiger Gebäude kann das häufig bestehende „Chaos“ durch eine verbesserte Etagenlogistik behoben werden. Die Planung einer Etagenlogistik ermöglicht eine insgesamt effizientere Arbeitsplatzgestaltung bei der Errichtung mehrgeschossiger Gebäude. Nicht wertschöpfende Tätigkeiten können im Sinne des Lean‐Gedankens reduziert und die Produktivität in der Ausführungsphase erhöht werden. In diesem Beitrag wird ein modellbasiertes Konzept zur Planung der Etagenlogistik für Ausbauprozesse im Hochbau vorgestellt. Im ersten Teil wird der Bedarf einer modellbasierten Vorgehensweise formuliert und das Grundgerüst des Konzepts dargestellt. Das entwickelte Konzept zeigt die großen Potenziale zur effizienteren Arbeitsplatzgestaltung und Arbeitsorganisation bei der Errichtung mehrgeschossiger Gebäude auf. Im zweiten Teil wird das Konzept anhand eines Beispielprojekts und ‐gewerks (Trockenbau) diskutiert.
Tragverhalten von Balkenreihentragwerken
Authors: Steinbock Oliver , Mertzsch Olaf , Hampel Torsten 
Published: November 2023

AbstractDie Nachweisformate aus der Nachrechnungsrichtlinie und ihrer Ergänzung sind bei zahlreichen Brückensystemen der alten Bundesländer anwendbar. Problematisch ist die Übertragbarkeit auf einen großen Teil der älteren Brückentragwerke, welche auf dem Gebiet der ehemaligen Deutschen Demokratischen Republik (DDR) liegen. Die Konstruktionen weisen besondere Spezifikationen auf, wie sie lediglich in der ehemaligen DDR ausgeführt wurden. Insbesondere die sogenannten Balkenreihentragwerke sind, sowohl im Bestand der Landesbauverwaltungen als auch dem von Kommunen, noch weit verbreitet. Aufgrund ihrer Häufigkeit und ihrer besonderen Konstruktion würden angepasste Rechenansätze die Bewertung dieser Tragwerke stark erleichtern. In der DDR wurde fast ausschließlich Spannstahl aus Hennigsdorfer Produktion verwendet, der als spannungsrisskorrosionsanfällig gilt. Im Vergleich mit Ortbetonbauwerken wird bei Fertigteilkonstruktionen jedoch von einer besseren Fertigungsqualität ausgegangen, sodass aktuell von einer Nichtbetroffenheit dieses Tragwerktyps ausgegangen wird. Der Beitrag beschreibt entsprechende Hintergründe und Berechnungsempfehlungen zu diesem besonderen Brückentyp. Die Erkenntnisse beruhen auf Erfahrungen aus einem Rückbau an einem Balkenreihentragwerk im Zuge der A 19. Hier ergab sich die bisherig einmalige Möglichkeit, Untersuchungen an einem Brückenüberbau durchzuführen, welcher als Balkenreihentragwerk ausgeführt war. Es werden die elementaren Ergebnisse überblicksartig zusammengefasst und Empfehlungen für die rechnerische Bewertung gegeben.
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis
Authors: Karunarathne Wisurumuni Arachchilage Hasitha Maduranga , Lee Kyoung Tae , Choi Yung Hyun , Kang Chang‐Hee , Lee Mi‐Hwa , Kim Sang‐Hun , Kim Gi‐Young 
Published: November 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic lung condition characterized by the abnormal regulation of extracellular matrix (ECM) and epithelial‐mesenchymal transition (EMT). In this study, we investigated the potential of rutin, a natural flavonoid, in attenuating transforming growth factor‐β (TGF‐β)‐induced ECM regulation and EMT through the inhibition of the TGF‐β type I receptor (TβRI)‐mediated suppressor of mothers against decapentaplegic (SMAD) signaling pathway. We found that non‐toxic concentrations of rutin attenuated TGF‐β‐induced ECM‐related genes, including fibronectin, elastin, collagen 1 type 1, and TGF‐β, as well as myoblast differentiation from MRC‐5 lung fibroblast cells accompanied by the downregulation of α‐smooth muscle actin. Rutin also inhibited TGF‐β‐induced EMT processes, such as wound healing, migration, and invasion by regulating EMT‐related gene expression. Additionally, rutin attenuated bleomycin‐induced lung fibrosis in mice, thus providing a potential therapeutic option for IPF. The molecular docking analyses in this study predict that rutin occludes the active site of TβRI and inhibits SMAD‐mediated fibrotic signaling pathways in lung fibrosis. These findings highlight the potential of rutin as a promising anti‐fibrotic prodrug for lung fibrosis and other TGF‐β‐induced fibrotic and cancer‐related diseases; however, further studies are required to validate its safety and effectiveness in other experimental models.
White matter microstructure is differently associated with executive functioning in youth born with congenital heart disease and youth born preterm
Authors: Easson Kaitlyn , Khairy May , Rohlicek Charles V. , Gilbert Guillaume , Majnemer Annette , Nguyen Kim‐Anh , Luu Thuy Mai , Couture Élise , Nuyt Anne‐Monique , Deoni Sean C. L. , Descoteaux Maxime , Brossard‐Racine Marie 
Published: November 2023

AbstractIntroductionExecutive function deficits and adverse psychological outcomes are common in youth with congenital heart disease (CHD) or born preterm. Association white matter bundles play a critical role in higher order cognitive and emotional functions and alterations to their microstructural organization may result in adverse neuropsychological functioning. This study aimed to examine the relationship of myelination and axon density and orientation alterations within association bundles with executive functioning, psychosocial well‐being, and resilience in youth with CHD or born preterm.MethodsYouth aged 16 to 26 years born with complex CHD or preterm at ≤33 weeks of gestational age and healthy controls completed a brain MRI and self‐report assessments of executive functioning, psychosocial well‐being, and resilience. Multicomponent driven equilibrium single‐pulse observation of T1 and T2 and neurite orientation dispersion and density imaging were used to calculate average myelin water fraction (MWF), neurite density index (NDI), and orientation dispersion index values for eight bilateral association bundles. The relationships of bundle‐average metrics with neuropsychological outcomes were explored with linear regression and mediation analyses.ResultsIn the CHD group, lower MWF in several bundles was associated with poorer working memory and behavioral self‐monitoring and mediated self‐monitoring deficits relative to controls. In the preterm group, lower NDI in several bundles was associated with poorer emotional control and lower MWF in the left superior longitudinal fasciculus III mediated planning/organizing deficits relative to controls. No significant relationships were observed for psychosocial well‐being or resilience.ConclusionThe findings of this study suggest that microstructural alterations to association bundles, including lower myelination and axon density, have different relationships with executive functioning in youth with CHD and youth born preterm. Future studies should aim to characterize other neurobiological, social, and environmental influences that may interact with white matter microstructure and neuropsychological functioning in these at‐risk individuals.
Microfluidic chip as a promising evaluation method in assisted reproduction: A systematic review
Authors: Wu Tong , Wu Yangyang , Yan Jinfeng , Zhang Jinjin , Wang Shixuan 
Published: November 2023

AbstractThe aim of assisted reproductive technology (ART) is to select the high‐quality sperm, oocytes, and embryos, and finally achieve a successful pregnancy. However, functional evaluation is hindered by intra‐ and inter‐operator variability. Microfluidic chips emerge as the one of the most powerful tools to analyze biological samples for reduced size, precise control, and flexible extension. Herein, a systematic search was conducted in PubMed, Scopus, Web of Science, ScienceDirect, and IEEE Xplore databases until March 2023. We displayed and prospected all detection strategies based on microfluidics in the ART field. After full‐text screening, 71 studies were identified as eligible for inclusion. The percentages of human and mouse studies equaled with 31.5%. The prominent country in terms of publication number was the USA (n = 13). Polydimethylsiloxane (n = 49) and soft lithography (n = 28) were the most commonly used material and fabrication method, respectively. All articles were classified into three types: sperm (n = 38), oocytes (n = 20), and embryos (n = 13). The assessment contents included motility, counting, mechanics, permeability, impedance, secretion, oxygen consumption, and metabolism. Collectively, the microfluidic chip technology facilitates more efficient, accurate, and objective evaluation in ART. It can even be combined with artificial intelligence to assist the daily activities of embryologists. More well‐designed clinical studies and affordable integrated microfluidic chips are needed to validate the safety, efficacy, and reproducibility.Trial registration: The protocol was registered in the Open Science Frame REGISTRIES (identification: osf.io/6rv4a).