bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of delay of local control in nonmetastatic extremity primary osteosarcoma
Authors: Halalsheh Hadeel , Ismael Taleb , Boheisi Mohammad , Shehadeh Ahmad , Sultan Iyad 
Published: October 2023

AbstractIntroductionThe timing of local control (LC) is not well studied in osteosarcoma. We assessed the impact of the delay of LC on the survival outcome of patients with osteosarcoma.MethodsWe conducted a retrospective analysis of children (≤18 years) with nonmetastatic extremity primary osteosarcoma at King Hussein Cancer Center from January 2005 until March 2020. Patients’ demographics, disease characteristics, and outcomes were collected. Events were defined as death, progression, or relapse. Cox proportional hazards regression was used for univariable and multivariable comparisons of different covariates.ResultsEighty‐two patients were included; 41 (50%) were females; the median age was 12.5 years (range: 5.9–18). Sixty‐four patients (78%) underwent LC by limb‐salvage surgery. Fifteen patients (18%) had a delay of LC greater than or equal to 18 weeks. After a median follow‐up of 54 months (range: 8–188), the 5‐year event‐free survival (EFS) and overall survival (OS) were 55.3% ± 5.8% and 66.6% ± 6%, respectively. On univariable analysis, LC greater than or equal to 18 weeks, progression before LC, amputation, and poor histologic response were associated with worse EFS (p = .007, .007, .006, .002) and OS (p = .01, .001, .006, .004). On multivariable analysis, LC greater than or equal to 18 weeks, progression before LC, and poor histologic response were associated with worse EFS (p < .001, .007, .002); and OS (p < .001, .007, .008). Male gender was associated with worse OS on univariable and multivariable analysis (both p = .02). After exclusion of patients with early progression before Week 11, good histologic response and LC less than 18 weeks were associated with better EFS (p = .04 and .03). While good histologic response was associated with better OS (p = .02), LC less than 18 weeks was not significant (p = .2).ConclusionsOur findings suggest that delay in LC could have an impact on the outcomes in patients with osteosarcoma. However, further investigations involving larger sample sizes and longer follow‐up are necessary to fully comprehend the extent of this influence.
Pediatric arterial thrombosis: A single‐institution cohort study of patient characteristics and thrombosis outcomes
Authors: Abdelghani Eman , Agarwal Shreya , Stanek Joseph , Sankar Amanda , Kerlin Bryce A. , Rodriguez Vilmarie 
Published: October 2023

AbstractBackgroundArterial thrombosis (AT) is an increasingly recognized complication in pediatrics. Consensus clinical practice guidelines suggest immediate removal of the indwelling arterial catheter and a short course (5‐7 days) of anticoagulation. The optimal duration and modality of antithrombotic therapy in children are yet to be determined.AimsDescribe treatment patterns and outcomes in pediatric patients with AT and explore predictors for complete thrombus resolution or long‐term complications.MethodsSingle‐institution retrospective study. Patients were identified by ICD‐9 and ICD‐10 codes for the diagnosis of AT or reports of AT on ultrasound from January 1, 2012, to October 1, 2022. Descriptive and logistic regression analyses were used.Results101 patients were included. The median age was 2.2 months. The most common underlying diagnoses were congenital heart disease (39.6%) and infection (22.8%). A majority of patients had symptomatic thrombosis in an extremity, and 78% were catheter‐associated. 81% of patients received anticoagulation with a median duration of 35 days. Out of the 70 patients who were treated with anticoagulation alone and had a follow‐up imaging, 70% had complete resolution after 90 days of anticoagulation. No clear predictors of complete resolution were identified. Eighteen patients had long‐term sequelae secondary to arterial insufficiency. Those with infection‐associated AT were more likely to have long‐term complications. The major and clinically relevant non‐major bleeding rate was 11%.ConclusionDuration of anticoagulation was widely variable, and 70% of patients achieved complete resolution by 90 days of anticoagulation. A significant proportion of patients developed long‐term sequelae secondary to arterial insufficiency. Sepsis/infection at the time of diagnosis with AT was more likely to be associated with long‐term complications.
CRISPR/Cas9‐mediated mutagenesis of the white gene in an ectoparasitic wasp, Habrobracon hebetor
Authors: Bai Xue , Yu Kaili , Xiong Shijiao , Chen Jin , Yang Yi , Ye Xinhai , Yao Hongwei , Wang Fang , Fang Qi , Song Qisheng , Ye Gongyin 
Published: October 2023

AbstractBACKGROUNDThe ectoparasitic wasp Habrobracon hebetor (Hymenoptera, Braconidae) can parasitize various species of lepidopteran pests. To maximize its potential for biological control, it is necessary to investigate its gene function through genome engineering.RESULTSTo test the effectiveness of genome engineering system in H. hebetor, we injected the mixture of clustered regularly interspaced short palindromic repeats (CRISPR) ‐associated (Cas) 9 protein and single guide RNA(s) targeting gene white into embryos. The resulting mutants display a phenotype of eye pigment loss. The phenotype was caused by small indel and is heritable. Then, we compared some biological parameters between wildtype and mutant, and found there were no significant differences in other parameters except for the offspring female rate and adult longevity. In addition, cocoons could be used to extract genomic DNA for genotype during the gene editing process without causing unnecessary harm to H. hebetor.CONCLUSIONOur results demonstrate that the CRISPR/Cas9 system can be used for H. hebetor genome editing and it does not adversely affect biological parameters of the parasitoid wasps. We also provide a feasible non‐invasive genotype detection method using genomic DNA extracted from cocoons. Our study introduces a novel tool and method for studying gene function in H. hebetor, and may contribute to better application of H. hebetor in biocontrol. © 2023 Society of Chemical Industry.
Current and potential pest threats for canola in the Canadian Prairies
Authors: Cornelsen Justine EJ , Ort Nathaniel WW , Gabert R Keith , Epp Ian , Rempel Curtis B 
Published: October 2023

AbstractCanola/oilseed rape (Brassica napus L.) production in Canada has increased to become a foundational crop in the Canadian Prairies and an important economic driver of this region. The increase in seeded area, and by association its reduction in‐crop rotation frequency, has made it easier for pests to overcome current recommended agronomic management practices. The Canola Council of Canada has been successful in involving the entire commodity value chain in promoting and strengthening the Canadian canola industry; however, because of this production increase it is critically important to understand, evaluate and mitigate the potential risks of canola yield losses to current and potential pests. This Perspective provides an overview of what are currently the most damaging insects, pathogens and weeds to canola in the Canadian Prairies, potential future threats and opportunities farmers, agronomists and researchers can take to minimize these risks. © 2023 Society of Chemical Industry.
Quantifying the impact of Psylliodes chrysocephala injury on the productivity of oilseed rape
Authors: Coston Duncan J , Clark Suzanne J , Breeze Tom D , Field Linda M , Potts Simon G , Cook Samantha M 
Published: October 2023

AbstractBACKGROUNDCurrent European Union and United Kingdom legislation prohibits the use of neonicotinoid insecticidal seed treatments in oilseed rape (OSR, Brassica napus). This ban, and the reduction in efficacy of pyrethroid insecticide sprays due to resistance, has exacerbated pest pressure from the cabbage stem flea beetle (Psylliodes chrysocephala) in winter OSR. We quantified the direct impact of P. chrysocephala injury on the productivity of OSR. Leaf area was removed from young plants to simulate differing intensities of adult feeding injury alone or in combination with varying larval infestation levels.RESULTSOSR can compensate for up to 90% leaf area loss at early growth stages, with no meaningful effect on yield. Significant impacts were observed with high infestations of more than five larvae per plant; plants were shorter, produced fewer flowers and pods, with fewer seeds per pod which had lower oil content and higher glucosinolate content. Such effects were not recorded when five larvae or fewer were present.CONCLUSIONThese data confirm the yield‐limiting potential of the larval stages of P. chrysocephala but suggest that the current action thresholds which trigger insecticide application for both adult and larval stages (25% leaf area loss and five larvae/plant, respectively) are potentially too low as they are below the physiological injury level where plants can fully compensate for damage. Further research in field conditions is needed to define physiological thresholds more accurately as disparity may result in insecticide applications that are unnecessary to protect yield and may in turn exacerbate the development and spread of insecticide resistance in P. chrysocephala. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Neighbourhood socioeconomic position, prenatal care and fulfilment of postpartum permanent contraception: Findings from a multisite cohort study
Authors: Berg Kristen A. , Bullington Brooke W. , Gunzler Douglas D. , Miller Emily S. , Boozer Margaret , Serna Tania , Bailit Jennifer L. , Arora Kavita S. 
Published: October 2023

AbstractIntroductionResearch suggests neighbourhood socioeconomic vulnerability is negatively associated with women's likelihood of receiving adequate prenatal care and achieving desired postpartum permanent contraception. Receiving adequate prenatal care is linked to a greater likelihood of achieving desired permanent contraception, and access to such care may be critical for women with Medicaid insurance given that the federally mandated Medicaid sterilization consent form must be signed at least 30 days before the procedure. We examined whether adequacy of prenatal care mediates the relationship between neighbourhood socioeconomic position and postpartum permanent contraception fulfilment, and examined moderation of relationships by insurance type.MethodsThis secondary analysis of a retrospective cohort study examined 3012 Medicaid or privately insured individuals whose contraceptive plan at postpartum discharge was permanent contraception. Path analysis estimated relationships between neighbourhood socioeconomic position (economic hardship and inequality, financial strength and educational attainment) and permanent contraception fulfilment by hospital discharge, directly and indirectly through adequacy of prenatal care. Multigroup testing examined moderation by insurance type.ResultsAfter adjusting for age, parity, weeks of gestation at delivery, mode of delivery, race, ethnicity, marital status and body mass index, having adequate prenatal care predicted achieving desired sterilization at discharge (β = 0.065, 95% confidence interval [CI]: 0.011, 0.117). Living in neighbourhoods with less economic hardship (indirect effect −0.007, 95% CI: −0.015, −0.001), less financial strength (indirect effect −0.016, 95% CI: −0.030, −0.002) and greater educational attainment (indirect effect 0.012, 95% CI: 0.002, 0.023) predicted adequate prenatal care, in turn predicting achievement of permanent contraception by discharge. Insurance status conditioned some of these relationships.ConclusionContact with the healthcare system via prenatal care may be a mechanism by which neighbourhood socioeconomic disadvantage affects permanent contraception fulfilment, particularly for patients with Medicaid. To promote reproductive autonomy and healthcare equity, future inquiry and policy might closely examine how neighbourhood social and economic characteristics interact with Medicaid mandates.
Comparison of entropion outcome with and without intervention in Romane and Ile de France sheep breeds
Authors: Esmaeili Hossein , Alinejad Amir Hossein , Hamedi Mona , Villanueva‐Saz Sergio , de Arcaute Marta Ruiz , Pérez Diana , Ibañez Juan , Lacasta Delia 
Published: October 2023

AbstractBackgroundCongenital entropion is the most frequent ocular disorder in newborn lambs of certain sheep breeds, which, if not treated, can result in complete blindness and death due to starvation.ObjectivesThe aims of this study were to compare the spontaneous healing of entropion in two breeds and assess the outcome of cases with and without therapeutic intervention.MethodsA total of 158 entropion cases (119 Ile de France and 39 Romane) were investigated, and swab samples were collected from the cornea and conjunctiva of 73 of the affected lambs for bacteriological investigation. In addition, an ocular intervention was carried out in 123 affected animals.ResultsThe Romane breed developed entropion at an average age of 7 days compared to the Ile de France, which developed it at an average age of 1 day. Likewise, significant differences were found between bilateral and unilateral involvement in both breeds. Meanwhile, 22.1% of cases recovered spontaneously, and the highest rate of spontaneous recovery without intervention was observed in the Romane breed (66%). Bacteria isolated from ocular samples included Staphylococcus spp. (42.5%), Bacillus spp. (21.9%), Trueperella pyogenes (13.7%), Corynebacterium spp. (12.3%) and Escherichia coli (9.6%).ConclusionsThe results of the study showed that the onset time of entropion, bilateral involvement, the severity of the process and the need for re‐treatment were higher in the Ile de France breed than in the Romane breed. Likewise, the Romane breed showed a higher degree of spontaneous recovery of entropion.
Inverse Magnus Effect in a Rarefied Gas
Authors: Taguchi Satoshi , Tsuji Tetsuro 
Published: October 2023

AbstractThe transverse force exerted on a rotating sphere immersed in an otherwise uniform flow of a rarefied gas is investigated based on the Bhatnagar–Gross–Krook (BGK) model of the Boltzmann equation assuming the Maxwell boundary condition on the sphere. In several existing studies, it has been shown that the transverse force acting on the sphere, also known as the Magnus force, has opposite signs in the free molecular and continuum flows. The present study intends to clarify the force’s transition in terms of the Knudsen number (i.e., the reciprocal ratio of the sphere radius to the molecular mean free path) with a particular interest in the impact of the sphere’s surface accommodation. It is found that the threshold of the Knudsen number, at which the transverse force changes the sign, depends only weakly on the accommodation coefficient, suggesting certain robustness in the threshold. The present study is an extension of the previous work [S. Taguchi and T. Tsuji, J. Fluid. Mech. 933, A37 (2022)], in which the case of complete accommodation (diffuse reflection) is exclusively considered.
Behavioral and morphological traits influencing variation in task performance of Camponotus vagus ants
Authors: Trigos-Peral G. , Maák I. E. , Ślipiński P. , Witek M. 
Published: October 2023

AbstractThe colony performance of social insects is supported by an efficient allocation of tasks among workers in the colony. The division of labor among ant workers is linked to age and caste polyethism, however, only a few studies have shown the relationship between workers’ behavioral variation and task performance. In this study, we investigated the task syndrome by testing the relationship between behavioral traits with task performance andlocation switching(switching the performance of tasks from inside to outside the nest) in the same-age workers ofCamponotus vagusants. We also investigated the division of labor in workers with and withoutlocation switchingby checking if each caste is characterized by specific behavioral traits or tasks. Moreover, we checked whether the difference in the worker’s body size and its lifespan can influence task performance. Our results support the existence of task syndrome in ant workers by showing how individuals with specific behavioral traits are more likely to perform specific tasks within the colony. Moreover, the time oflocation switchingwas correlated with the tasks performed by the workers (brood care,selfgroomingandwalking) and their behavioral traits (aggressivenessandtotal distance). In addition, worker size and lifespan are shown to influence task performance by the workers. Altogether, our study underpins the relationship between the behavioral traits and the task allocation and performance of workers within an ant colony.
Grasping AI: experiential exercises for designers
Authors: Murray-Rust Dave , Lupetti Maria Luce , Nicenboim Iohanna , Hoog Wouter van der 
Published: October 2023

AbstractArtificial intelligence (AI) and machine learning (ML) are increasingly integrated into the functioning of physical and digital products, creating unprecedented opportunities for interaction and functionality. However, there is a challenge for designers to ideate within this creative landscape, balancing the possibilities of technology with human interactional concerns. We investigate techniques for exploring and reflecting on the interactional affordances, the unique relational possibilities, and the wider social implications of AI systems. We introduced into an interaction design course (n = 100) nine ‘AI exercises’ that draw on more than human design, responsible AI, and speculative enactment to create experiential engagements around AI interaction design. We find that exercises around metaphors and enactments make questions of training and learning, privacy and consent, autonomy and agency more tangible, and thereby help students be more reflective and responsible on how to design with AI and its complex properties in both their design process and outcomes.
Tidal harmonics retrieval using GNSS-R dual-frequency complex observations
Authors: Rajabi Mahmoud , Hoseini Mostafa , Nahavandchi Hossein , Asgarimehr Milad , Semmling Maximilian , Ramatschi Markus , Goli Mehdi , Wickert Jens 
Published: October 2023

AbstractTidal analysis and methods for estimation and prediction of ocean tidal constitutes are essential in a large area of scientific disciplines, for example, navigation, onshore and offshore engineering, and production of green energy. Ground-based Global Navigation Satellite System-Reflectometry (GNSS-R) has been proposed as an alternative method for measuring sea surface height. We use 6 years of GNSS-R observations at In-phase and Quadrature levels from July 2015 to May 2021 obtained from a dedicated receiver and sea-looking left hand circular polarization antenna for estimating sea level (SL). In the first step, the multivariate least-square harmonic estimation (LS-HE) method is applied for SL estimation. Then, final SL time series are generated by combining estimated SL from all satellites at L1 and L2 frequencies in the averaging step. The 6-year root-mean-square error between GNSS-R L12 sea surface heights and a collocated tide gauge (TG) is 5.8 cm with a correlation of 0.948 for a high temporal resolution of 5 min with 15 min averaging window. Afterward, using the univariate LS-HE, we detect tidal harmonics with periods between 30 min to 1 year. The detection results highlight a good match between GNSS-R and TG. Higher harmonics, i.e., the periods shorter than 3 h, show stronger signatures in GNSS-R data. Finally, we estimate the amplitude and phase of standard tidal harmonics from the two datasets. The results show an overall good agreement between the datasets with a few exceptions.
Silver-Mixed Port Reduces Venous Access Port Related Infection Rate Compared to Non-Silver-mixed Port: A Single-center Retrospective Analysis
Authors: Suzuki Takayuki , Michimoto Kenkichi , Hasumi Jun , Kisaki Shunsuke , Hasegawa Yasuaki , Fujimori Ayako , Yoshimatsu Lynn , Ashida Hirokazu , Ojiri Hiroya 
Published: October 2023

Abstract
Purpose
Totally implantable venous access ports (TIVAPs) are increasingly used as safe and convenient central venous access devices. However, several TIVAP-related complications occur, with port/catheter infection being most common. Silver-mixed ports have recently been introduced in anticipation of reducing TIVAP infection. This study aimed to investigate the efficacy of this device in reducing port infection by examining groups with and without silver-mixed devices.

Materials and Methods
From April 2017 to July 2022, silver-mixed ports (S group) and non-silver-mixed port group (NS group) were reviewed at our institution. The incidence of TIVAP-related infections, patient characteristics, and bacteriological data were evaluated. Univariate and multivariate analyses were used to evaluate risk factors for TIVAP-related infection.

Results
A total of 607 patients (S group, n = 203; NS group, n = 404) were enrolled. The rates of TIVAP-related infection were 3.0% (n = 6) and 7.7% (n = 31) in the S and NS groups, respectively. The incidence of total infection per 1000 catheter-days were 0.114 and 0.214 the S and NS groups, respectively. In the entire group, the rates of infection were 6.1% (n = 37) and the incidence of total infection per 1000 catheter-days was 0.187. Univariate and multivariate analyses revealed a significantly lower TIVAP-related infection rate in S group than NS group (p = 0.0216, odds ratio = 2.88 confidence interval: 1.17–7.08). No gram-negative rods were detected in the S group as port infection.

Conclusion
Silver-mixed port may be feasible in preventing port infection.
Level of evidence.
Level 3, Local non-random sample.
Ventricular arrhythmia burden in ICD patients during the second wave of the COVID-19 pandemic
Authors: Rath Benjamin , Doldi Florian , Willy Kevin , Ellermann Christian , Köbe Julia , Güner Fatih , Reinke Florian , Lange Philipp Sebastian , Frommeyer Gerrit , Eckardt Lars 
Published: October 2023

Abstract
Aim
COVID-19 has been associated with cardiovascular complications including ventricular arrhythmias (VA) and an increased number of out-of-hospital cardiac arrests. Nevertheless, several authors described a decrease of VA burden in patients with an implantable defibrillator (ICD) during the first wave of the COVID-19 pandemic. The objective of this study was to determine if these observations could be transferred to later periods of the pandemic as well.

Methods
We retrospectively analyzed a total of 1674 patients with an ICD presenting in our outpatient clinic during the second wave of the COVID-19 pandemic and during a control period for the occurrence of VA requiring ICD interventions.

Results
Seven hundred ninety-five patients with an ICD had a device interrogation in our ambulatory clinic during the second wave of the COVID-19 pandemic compared to eight hundred seventy-nine patients in the control period. There was significant higher amount of adequate ICD therapies in the course of the COVID-19 period. Thirty-six patients (4.5%) received in total eighty-five appropriate ICD interventions during COVID-19, whereas only sixteen patients (1.8%) had sustained VA in the control period (p = 0.01).

Conclusion
In contrast to the first wave of COVID-19, which was characterized by a decrease or least stable number of ICD therapies in several centers, we found a significant increase of VA in ICD patients during the second wave of COVID-19. Possible explanations for this observation include higher infectious rates, potential cardiac side effects of the vaccination as well as personal behavioral changes, or reduced utilization of medical services.