bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of repetitive transcranial magnetic stimulation on upper limb motor function in stroke patients with right hemiplegia based on EEG microstates and EMG
Authors: Xin Rong , Zhao Shanguang , Yu Xianxian , Cheng Siman , Xie Jiale , Ling Gengqiang , Wei Xin , Wang Pu , Chen Steve SHYH-Ching 
Published: December 2023

Abstract

Stroke is a neurological disorder that profoundly affects patients' neural function and daily life. Although rehabilitation methods have made significant progress, there is still a need for innovative treatment strategies to improve the recovery outcomes of stroke patients. In this study, we employed electroencephalography (EEG) microstate analysis to investigate the influence of transcranial magnetic stimulation (TMS) on upper limb functional Rehabilitation in stroke patients with right hemiplegia, while also exploring the relationship between microstate patterns and improvements in muscle strength. The study involved 20 stroke patients with right-sided hemiparesis and 20 healthy right-handed control subjects recruited. All subjects underwent EEG and EMG data collection in a resting state. Before and after treatments，using the Upper Extremity Section of the Fugl-Meyer Assessment(FMA-UE) and the Action Research Arm Test (ARAT) to assess the upper extremity function of stroke patients. After one week of TMS treatment, data collection was repeated for patients. After TMS intervention, the FMA-UE scores and ARAT scores of stroke patients were significantly improved compared to the pre-treatment period (p < 0.05). Microstate B exhibited reduced time coverage and occurrence frequency in stroke patients (p < 0.05), but following TMS treatment, there was a significant increase in time coverage, approaching levels seen in the healthy control group (p < 0.05). Furthermore, we observed a significant reduction in the duration and time coverage of Microstate C and Microstate D following TMS treatment (p < 0.05). Encouragingly, the improvement in time coverage and occurrence frequency of Microstate B was positively correlated with the enhanced abilities of specific muscle groups, including upper limb muscles such as the flexor carpi ulnaris and extensor carpi ulnaris, highlighting the close relationship between Microstate B and improvements in motor control and muscle coordination. Changes in Microstate C were positively correlated with increased upper limb muscle strength, suggesting that Microstate C may play a crucial role in motor control and muscle coordination. This suggests that TMS may have a positive impact on neurorehabilitation in stroke patients, particularly concerning rehabilitation goals associated with Microstate B. In conclusion, our study underscores TMS can effectively promote upper limb motor function in stroke patients with right-sided hemiplegia and the critical link between microstate analysis and motor function recovery in stroke patients. Microstate B and Microstate C may serve as physiological indicators for assessing the progress of motor rehabilitation, providing valuable insights for developing more effective rehabilitation strategies and personalized rehabilitation plans.
A statistical analysis of the impact of gun ownership on mass shootings in the United States between 2013 and 2022
Authors: Kerns Lucy , Daraklis Madison , Pol Mehul , Johnson Lindsey , Salvatora Cianna 
Published: December 2023

Abstract
Mass shootings are becoming more frequent in the United States, posing a significant threat to public health and safety in the country. In the current study, we intended to analyze the impact of state-level prevalence of gun ownership on mass shootings - both the frequency and severity of these events. We applied the negative binomial generalized linear mixed model to investigate the association between gun ownership rate, as measured by a proxy (i.e, the proportion of suicides committed with firearms to total suicides), and population-adjusted rates of mass shooting incidents and fatalities at the state level from 2013 to 2022. Gun ownership was found to be significantly associated with the rate of mass shooting fatalities. Specifically, our model indicated that for every 1-SD increase - that is, for every 12.5% increase - in gun ownership, the rate of mass shooting fatalities increased by 34% (p-value < 0.001). However, no significant association was found between gun ownership and rate of mass shooting incidents. These findings suggest that restricting gun ownership (and therefore reducing availability to guns) may not decrease the number of mass shooting events, but it may save lives when these events occur.
Adaptation and validation of moral distress thermometer in Chinese nurses
Authors: Tian Xu , Gan Xiuni , Ren Yi , Li Feili , Herrera Maria F Jimenez , Liu Fangrong 
Published: December 2023

Abstract

Background:Moral distress seriously affects professional nurses, and a number of instruments have been developed to measure the level of moral distress. The moral distress thermometer (MDT) is one of the commonly used instruments that can rapidly measure real-time moral distress; however, it remains unclear whether it is still useful in the Chinese cultural context.Aim:This study aimed to adapt and validate the MDT among Chinese registered nurses.Research design:An online, cross-sectional, survey study of adapting and validating Chinese version of MDT.Participants and research context:A total of 182 registered nurses effectively finished this survey. The correlation between MDT score and the score of the moral distress scale-revised version (MDS-R) was used for evaluating convergent validity, and MDT scores of registered nurses who working in different departments and who made different actions to the final question of the MDS-R were compared by using one-way ANOVA to evaluate construct validity.Ethical considerations:The Ethics Committee of Chongqing Traditional Chinese Medicine Hospital approved this study (XYMS-20).Results:The Chinese version of MDT was described as relevant to measure moral distress. The mean MDT score and mean MDS-R score were 2.54 and 38.66, respectively, and the correlation between these two scores was significantly moderate (r= 0.41). Nurses working different departments reported different levels of moral distress, and those working in intensive care unit reported the highest level of moral distress than those working in other departments (p = 0.04). The MDT scores between nurses who presented different actions to their position were also significantly different, and those who had ever left and those who had considered leaving but did not leave reported significantly higher moral distress.Conclusion:The MDT is a reliable, valid, and easy-to-use instrument to rapidly measure the real-time moral distress of registered nurses in China.
Reproducible Neuronal Components found using Group Independent Component Analysis in Resting State Electroencephalographic Data
Authors: Ochoa-Gómez John Fredy , Mantilla-Ramos Yorguin-José , Isaza Verónica Henao , Tobón Carlos Andrés , Lopera Francisco , Aguillón David , Suárez Jazmín Ximena 
Published: December 2023

Abstract

Objective: Evaluate the reliability of neural components obtained from the application of the group ICA (gICA) methodology to resting-state EEG datasets acquired from multiple sites.
Methods: Five databases from three sites, covering a total of 292 healthy subjects, were analyzed. Each dataset was segmented into groups of 15 subjects, for a total of 19 groups. Data were pre-processed using an automatic pipeline leveraging robust average referencing, wavelet-ICA and automatic rejection of epochs. On each group, stable gICA decompositions were calculated using the ICASSO methodology through a range of orders of decompositions. Each order was characterized by reliability and neuralness metrics, which were evaluated to select a single order of decomposition. Finally, using the decompositions of the selected order, a clustering analysis was performed to find the common components across the 19 groups. Each cluster was characterized by the mean scalp map, its dipole generator with its localization in Talairach coordinates, the spectral behavior of the associated time-series of the components, the assigned ICLabel class and metrics that reflected their reproducibility.
Results: Lower order of decompositions benefits the gICA methodology. At this, using an order of ten, the number of reproducible components with high neuronal information tends to be around nine. Of these, the bilateral motor, frontal medial, and occipital neuronal components were the most reproducible across the different datasets, appearing in more than 89% of the 19 groups evaluated.
Conclusion: We developed a workflow that allows finding reproducible spatial filters between different data sets. This contributes to the improvement of the spatial resolution of the EEG as a brain mapping technique.
DNA Methylation is associated with oxidative stress and genomic deregulation in diabetes mellitus
Authors: Sen Subhrojit 
Published: December 2023

Abstract

Background:
Retrotransposons may undergo aberrant methylation leading to genomic deregulation in diabetes mellitus. The present study evaluated the methylation of retrotransposons namely Alu, B1, and LINE-1 elements in glucose-induced endothelial cells (ECs) and T1DM. The correlation between methylation of these retrotransposons and oxidative stress was investigated. Additionally, methylation of FN1, VEGFa, and EDN1 genes was analyzed.
Methods:
Hot start PCR of the bisulfite converted DNA isolated from the ECs and kidneys for the methylation of retrotransposons was analyzed. Quantification of methylated DNA in ECs was performed by ELISA. The methylation of the FN1, VEGFa, and EDN1 genes was examined. Oxidative stress was evaluated by measuring the superoxide anion, mitochondrial reactive oxygen species (ROS), 8-Hydroxyguanosine (8-OHdG), and NF-kappaB p(65).
Results:
Hypermethylation of Alu and LINE-1 elements occurred in the high glucose- induced ECs. B1 hypermethylation was observed in the kidneys of T1DM mice. Hyperglycemia resulted in LINE-1 hypermethylation in the kidneys of T1DM mice. Hypermethylation of the FN1, VEGFa and EDN1 genes occurred in the high glucose-induced ECs and diabetic kidneys. Hypermethylation of the retrotransposons, oxidative stress and NF-kappaB p(65) were inhibited by 5-Aza-Dc and ginseng treatment.
Conclusion:
This study illustrated that retrotransposon hypermethylation and oxidative stress were evident in the glucose-induced ECs and T1DM along with hypermethylation of the FN1, VEGFa and EDN1 genes. The study also demonstrated the association between hypermethylation of these retrotransposons and oxidative stress in diabetes.
The Next-Generation Ecosystem Experiment Arctic Rainfall Simulator: a tool to understand the effects of changing rainfall patterns in the Arctic
Authors: Renner Caleb , Conroy Nathan , Thaler Evan , Collins Adam , Thomas Lauren , Dillard Shannon , Rowland Joel , Bennett Katrina 
Published: December 2023

Abstract

Rainfall frequency and intensity are expected to increase in the Arctic, with potential detrimental impacts on permafrost, leading to enhanced thawing and carbon release to the atmosphere. However, there have been very few studies on the effect of discrete rain events on permafrost in the Arctic and sub-Arctic. Conducting controlled rainfall experiments within permafrost landscapes can provide an improved understanding of the effect of changing intensity, duration, and timing of rain events on permafrost tundra ecosystems. Here, we describe the design and implementation of the Next-Generation Ecosystem Experiment Arctic Rainfall Simulator (NARS), a variable intensity (4–82 mm/h) rainfall simulator that can be used to study the effects of rainfall on permafrost stability. The NARS design includes a 3D-printed 4 cm H-flume and uses an eTape resistivity sensor that was calibrated (R2 = 0.9–0.96) to measure discharge from the system. NARS is designed to be lightweight, simple to construct, and can be easily deployed in remote locations. As a field validation of updated rainfall simulator design and modernized controls, NARS was tested on the Seward Peninsula, AK. Because of its portability, versatility in deployment, dimensions, and rainfall intensity, NARS represents a methodological innovation for researching the impacts of rainfall on permafrost environments.
Water environment response of urban water networks in the Pearl River Delta (China) under the influence of typhoon rain events
Authors: Shen Weiping , Jin Yuhao , Cong Peitong , Li Gengying 
Published: December 2023

Abstract
Identifying water quality parameter concentrations and their drivers is important for the prevention and control of water environment pollution. In this study, we constructed an inverse model of water quality parameters based on measured water quality parameters and remote sensing spectral data for this study area using artificial neural networks. We investigated the water environment response of the urban water network in the Pearl River Delta under the influence of typhoon rain events and explored their spatial heterogeneity using a multiscale geographically weighted regression model. The results indicate that in regions with a high level of urbanization, the dissolved oxygen (DO) concentration in river water is lower, and the ammonia nitrogen (NH3-N) concentration is higher. Under the influence of typhoon rain events of varying intensities, the response of water quality parameters in the urban water network of Zhongshan City varies. The intensity of rainfall determines the impact of typhoon rain events on water quality parameter concentrations. Our results are expected to improve the understanding of water quality trends under the influence of typhoon rain events and help policymakers and planners better develop water environment control strategies during typhoon transit.
Reducing particle accumulation in sewers for mitigation of combined sewer overflow impacts on urban rivers: a critical review of particles in sewer sediments
Authors: Wu Jun , Ma Yan , Song Shanshan 
Published: December 2023

Abstract

Sewer sediments contain various hazardous compounds, leading to significant pollution risks when combined sewer overflows (CSOs) occur without appropriate controls. This paper presents a comprehensive review of the issues associated with particles in sewers, specifically focusing on the non-negligible contribution of particulate matter to CSOs, which leads to pollution in urban rivers. Therefore, the sources of particulate matter in sewers, their contributions to the overflow particles, and the specific areas of concern when it comes to managing particulate matter during particle transportation are outlined. Overall, carefully considering the goal of avoiding sedimentation during the drainage system design is the most effective prevention and control method for pipeline sediment, where minimum velocity and minimum shear stress are the core parameters. The establishment of a flexible and adaptive particle simulation method in drainage pipelines requires reliable simulation of particle sedimentation and erosion, the development of sediment prevention facilities with strong adaptability, and a comprehensive evaluation of economic and environmental benefits. With the ongoing enhancement of urbanization in developing countries, such studies will have more practical significance.
Interprofessional practice and health care: a study in a Multi-professional Health residence
Authors: Silva Ana Beatriz Ferreira Barros da , Cardoso Talita Miranda Pitanga Barbosa , Leal Juliana Alves Leite , Araújo Mariana de Oliveira , Merces Magno Conceição das , Souza Marcio Costa de 
Published: December 2023

Objetivo: analisar as práticas de cuidado na perspectiva interprofissional em uma residência multiprofissional em saúde. Método: Pesquisa qualitativa de natureza exploratória realizada em um Programa de Residência Multiprofissional em Saúde de uma universidade pública do estado da Bahia, Brasil. As ferramentas para a produção dos dados foram a entrevista semi estruturada e o diário de campo. A amostra foi definida por meio da saturação dos dados composta por 13 residentes entrevistados distribuídos em cinco campos de atuação da residência (Saúde da Família, Saúde Mental, Nutrição Clínica, Oncologia e Terapia Intensiva). Os dados das entrevistas foram interpretados por meio de análise de conteúdo, onde emergiu uma categoria: Prática Interprofissional na Residência: experiências ou políticas? Resultados: As atividades práticas de caráter interprofissional ocorrem de acordo com o ponto de atenção para o cuidado, e essas vivências dependem dos trabalhadores desses locais, o que demonstra que não há uma política institucional. Na atenção básica, permite ao residente ter uma visão ampliada da saúde e, assim, sobressai à subjetividade, o que permite associar a formação ainda pautada no modelo biomédico. Considerações finais: As práticas interprofissionais acontecem principalmente com residentes de saúde da família e que o processo de formação do residente possibilita o desenvolvimento de uma perspectiva subjetiva sobre o cuidado, diferente dos demais módulos.
Palavras-Chave: Formação Profissional; Cuidado Centrado no Paciente; Educação Interprofissional.
O manejo peri-hospitalar de pacientes com Doença de Parkinson e pneumonia broncoaspirativa: relato de experiência
Authors: Faria Cristiane de Almeida , Almeida Yasmin Saba de , Tavares Felipe Guimarães 
Published: December 2023

Considerada a segunda doença neurodegenerativa mais prevalente na população idosa, a Doença de Parkinson é uma patologia crônica, de causa multifatorial, que dentre outros sintomas, provoca desordens do movimento. Advindas secundariamente, as alterações respiratórias podem ocasionar as pneumonias broncoaspirativas que levam a internações hospitalares recorrentes e podem compreender uma das principais causas de morte na Doença de Parkinson. Este estudo tem como objetivo descrever uma experiência exitosa, discutindo os principais aspectos relacionados ao manejo peri-hospitalar de pacientes com DP em tratamento de pneumonia broncoaspirativa, a partir da perspectiva de um profissional de fisioterapia. Trata-se de um relato de experiência sobre a atuação de um profissional de fisioterapia em uma Unidade de Internação na especialidade de Clínica Médica de um hospital de referência da Região Norte do Brasil, com pacientes com Doença de Parkinson em tratamento de pneumonia broncoaspirativa. O cuidado do paciente com Doença de Parkinson por seus familiares/cuidadores é envolto de desafios. O medo e a insegurança se tornam presentes no dia-a-dia quando se trata de um paciente acamado em domicílio com necessidade de cuidados que, muitas vezes, não é de experiência diária de um parente cuidador. Nesse contexto, o fisioterapeuta, juntamente dos demais membros da equipe multiprofissional, possui um papel fundamental no que tange a assistência peri-hospitalar do paciente parkinsoniano, de forma a garantir o treinamento adequado dos familiares/cuidadores para atuarem na aspiração de vias aéreas do paciente em uso de traqueostomia, para que seja possivel dar continidade nos cuidados domiciliares e reduzir a taxa de reinternação.
Palavras-Chave: Doença de Parkinson; Pneumonia Aspirativa; Manuseio das Vias Aéreas; Assistência Integral à Saúde.
Repercussões da violência doméstica contra mulher para crianças sob ótica de agentes comunitários de saúde
Authors: Couto Maria Vitória Oliveira , Morais Roberta Laíse Gomes Leite de , Luz Rosália Teixeira , Rodrigues Vanda Palmarella , Vilela Alba Benemérita Alves , Machado Juliana Costa 
Published: December 2023

Introdução: Comportamentos violentos em famílias com a presença de crianças traz repercussões adversas na sua saúde e no seu desenvolvimento. Objetivou-se averiguar as concepções dos agentes comunitários de saúde sobre as repercussões da violência doméstica contra a mulher para as crianças que convivem nesse contexto. Materiais e Métodos: Trata-se de uma pesquisa de cunho descritivo e exploratório de natureza qualitativa, cujos dados foram coletados de maio a agosto de 2019, em 11 Unidades de Saúde da Família, de um município do interior da Bahia, com 30 agentes comunitários de saúde e analisados a partir da técnica de análise de conteúdo modalidade temática. Resultados e Discussão: As repercussões da violência doméstica contra as mulheres interferem nas áreas físicas, cognitivas, emocionais e sociais de desenvolvimento infantil, afetando diretamente suas relações futuras. O uso de álcool e a dominação também se apresentaram como fatores precipitadores da violência entre mulheres e crianças. Constatou-se a negligência no cuidado à criança pela mãe, em decorrência da violência doméstica contra a mulher. Considerações finais: Os agentes comunitários de saúde podem corroborar para a ampliação de conhecimentos sobre as repercussões da violência na vida de mulheres e crianças. De modo que, sua atuação também possibilita o aperfeiçoamento de intervenções, por meio da promoção e prevenção à saúde de mulheres e crianças expostas à violência doméstica.
Palavras-chaves: Violência contra a Mulher; Exposição à Violência; Criança; Saúde da Família; Agentes Comunitários de Saúde.
Incidência e prognóstico das neoplasias de pâncreas: uma revisão integrativa da literatura
Authors: Rodrigues de Oliveira Silva Brendo , Lima de Moraes Ludmila , Conceição de Siqueira Emilio 
Published: December 2023

As neoplasias são patologias genéticas e/ou fenotípicas que muitas vezes levam à morte, sendo a neoplasia de pâncreas umas das mais insidiosas e de rápida evolução.O objetivo geral do presente artigo foi estudar a incidência e prognóstico das neoplasias de pâncreas, considerando suas manifestações clínicas, tratamentos de acordo estadiamento e respostas terapêuticas.Para tal, foi realizada uma pesquisa bibliográfica em bases de dados virtuais, na qual foram selecionados trabalhos que fundamentam o objetivo proposto.O estudo observou que ainda não há métodos eficazes para detecção precoce da patologia, levando a prognósticos reservados, uma vez que a localização retroperitonial da glândula torna a doença neoplásica assintomática até uma fase avançada e que não há marcadores diagnósticos específicos.
Palavras-chave: Neoplasias Pancreáticas; Incidência; Prognóstico.
The Interplay Between Gut Microbiota and Central Nervous System
Authors: Gervasi Teresa , Mandalari Giuseppina 
Published: December 2023

Abstract:
This review highlights the relationships between gastrointestinal microorganisms and the brain. The
gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling
mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic
nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this
context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and consequently
in neurodegenerative disorders. Several factors influence the susceptibility to oxidative stress by altering
the antioxidant status or free oxygen radical generation. Amongst these, of interest is alcohol, a commonly
used substance which can negatively influence the central nervous system and gut microbiota, with a key role
in the development of neurodegenerative disorder. The role of “psychobiotics” as a novel contrast strategy for
preventing and treating disorders caused due to alcohol use and abuse has been investigated.