bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron‐triggered signaling via ETS1 and the p38/JNK MAPK pathway regulates Bmp6 expression
Authors: Zurawska Gabriela , Jończy Aneta , Niklewicz Marta , Sas Zuzanna , Rumieńczyk Izabela , Kulecka Maria , Piwocka Katarzyna , Rygiel Tomasz P. , Mikula Michal , Mleczko‐Sanecka Katarzyna 
Published: January 2024

AbstractBMP6 is an iron‐sensing cytokine whose transcription in liver sinusoidal endothelial cells (LSECs) is enhanced by high iron levels, a step that precedes the induction of the iron‐regulatory hormone hepcidin. While several reports suggested a cell‐autonomous induction of Bmp6 by iron‐triggered signals, likely via sensing of oxidative stress by the transcription factor NRF2, other studies proposed the dominant role of a paracrine yet unidentified signal released by iron‐loaded hepatocytes. To further explore the mechanisms of Bmp6 transcriptional regulation, we used female mice aged 10–11 months, which are characterized by hepatocytic but not LSEC iron accumulation, and no evidence of systemic iron overload. We found that LSECs of aged mice exhibit increased Bmp6 mRNA levels as compared to young controls, but do not show a transcriptional signature characteristic of activated NFR2‐mediated signaling in FACS‐sorted LSECs. We further observed that primary murine LSECs derived from both wild‐type and NRF2 knock‐out mice induce Bmp6 expression in response to iron exposure. By analyzing transcriptomic data of FACS‐sorted LSECs from aged versus young mice, as well as early after iron citrate injections, we identified ETS1 as a candidate transcription factor involved in Bmp6 transcriptional regulation. By performing siRNA‐mediated knockdown, small‐molecule treatments, and chromatin immunoprecipitation in primary LSECs, we show that Bmp6 transcription is regulated by iron via ETS1 and p38/JNK MAP kinase‐mediated signaling, at least in part independently of NRF2. Thereby, these findings identify the new components of LSEC iron sensing machinery broadly associated with cellular stress responses.
Investigating surface integrity and mechanical behavior of selective laser melting for dental implants
Authors: Rezayat Mohammad , Ashkani Omid , Fadaei Raheleh 
Published: January 2024

AbstractSelective laser melting (SLM) is a contemporary manufacturing method that offers numerous advantages for producing various components. This research focuses on the examination of a dental implant sample fabricated using the SLM method. The investigation encompasses multiple aspects, including hardness, dimensional accuracy, strength, and surface properties. The results demonstrate that the hardness of the SLM sample is comparable to that of machined samples, establishing it as a viable alternative to traditional production methods. Dimensional tests reveal that the SLM sample adheres to the required acceptance limits for critical dimensions. The strength of the sample, with a value of 700 MPa, proves to be acceptable for medical applications. The presence of surface porosity and holes in the SLM sample highlights its potential for enhanced bone ossification. However, challenges associated with thread construction in the SLM process require further attention. Overall, this research showcases the promising aspects of the SLM method for dental implant production, while also identifying areas for future investigation and improvement.
Modulating Ce3+ Sites in Ce‐Zr Oxide Nanocatalysts through Protamine Biomineralization for Organophosphate Dephosphorylation
Authors: Jiang Junjie , Peña Jhair , Hadinata Lie William , Yang Yuwei , Thong Grace , Wright Joshua , Thomsen Lars , Gallington Leighanne C. , Scott Jason A. , Bedford Nicholas M. 
Published: January 2024

AbstractCatalytic is a crucial reaction for environmental detoxication of pesticides and neutralization of various molecules classified as chemical warfare agents. Herein, we report on a series of tunable Ce−Zr‐based metal oxides, (ZraCe1–aOx) prepared using a facile biomineralization technique, as catalysts for organophosphates dephosphorylation. Synchrotron scattering and spectroscopy methods showcase that ZraCe1–aOx catalysts are highly defective and exhibit an abundance of Ce3+ sites that promote oxygen vacancies needed for enhanced dephosphorylation reactions. The catalytic performance was assessed using a model para‐nitrophenyl phosphate reaction and showcases a strong dependence on Zr dopant concentration and subsequent tuning of the Ce3+/Ce4+ ratio. Analysis of synchrotron datasets allowed structure‐performance correlations between the Ce3+ concentration and associated oxygen vacancies, the dephosphorylation rate constant, and Zr concentration to be established, confirming that Ce3+ as active sites is positively correlated with the rate constant. We envision that similar biomineralization approaches can be used to fabricate Ce3+‐rich Ce−Zr oxide for environmental application in dephosphorylation and other hydrolysis reactions.
Outage and ergodic capacity analysis of a full‐duplex energy‐harvesting cooperative non‐orthogonal multiple access network
Authors: Baranwal Alok , Dhar Roy Sanjay , Kundu Sumit 
Published: January 2024

SummaryThis paper considers a dual‐hop cooperative relay‐based communication with uplink (UL) and downlink (DL) non‐orthogonal multiple access (NOMA), where communication between sources to destinations takes place parallelly in the same frequency band over a Rayleigh fading channels. The energy harvesting (EH)‐based full‐duplex (FD) relay helps in forwarding the message from the source node to the destination node via superposition coding, thus calling it a multiple sources full‐duplex energy‐harvesting cooperative relay NOMA (MS‐FD‐EH‐CR‐NOMA) system. Early works focus on EH from one source node or a dedicated power station. In this article, the communication between sources and destinations occurs in two slots where first slot deals with energy harvesting while in second slot information transmission occurs. We studied the effect of imperfect successive interference cancellation (ipSIC) and residual self‐interference (RSI) in decoding the message at the relay and the destinations. We derived the closed‐form expressions for the outage probability of each pair and the system outage probability of the MS‐FD‐EH‐CR‐NOMA system. Next, we derive the closed‐form expressions of ergodic capacity under Rayleigh distributed fading channels. Further, numerical results are validated by its simulation results using Monte Carlo simulations in MATLAB. The results obtained through this work are a good step towards designing multiple source–destination communication using NOMA and EH relay.
Application of broken windows theory to identify flow disruptions in neurosurgery procedure
Authors: Khan Asfandyar , Farooq Aimen , Elfallal Wissam , Gandhi Ravi , Vinas Federico , Boquet Albert J. 
Published: January 2024

AbstractAddressing flow disruptions (FDs) in neurosurgery requires a multifaceted approach. Strategies like improved communication protocols, minimizing interruptions, improving coordination among team, optimizing operating room layout, and promoting user‐centered design can help mitigate the challenges and enhance the overall flow and safety of neurosurgical procedures. Thirty neurosurgery cases were observed at two tertiary care facilities. The data collected were from wheels into the operating room to wheels out from the operating room. Data points were categorized using a human factors taxonomy known as RIPCHORD‐TWA (Realizing Improved Patient Care Through Human‐Centered Operating Room Design for Threat Window Analysis). Of the 541 total disruptions observed, coordination issues were the most prevalent (26.25%), followed by layout issues (26.06%), issues related to interruption (22.55%), communication (22.37%), equipment issues (2.40%) and usability issues (0.37%) comprised the remainder of the observations. This translated into one disruption every 2.7 min. Instead of focusing exclusively on errors and adverse events, we propose conceptualizing the accumulation of disruptions as “threat windows” to analyze potential threats to the integrity of the care system. This perspective allows for the improved identification of system weaknesses or threats, affording us the ability to address these inefficiencies and intervene before errors and adverse events may occur.
Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease
Authors: Luque Veronica , Crespo‐Escobar Paula , Hård af Segerstad Elin M. , Koltai Tunde , Norsa Lorenzo , Roman Enriqueta , Vreugdenhil Anita , Fueyo‐Díaz Ricardo , Ribes‐Koninckx Carmen 
Published: January 2024

AbstractBackground and ObjectiveCoeliac disease is a chronic, immune‐mediated disorder for which the only treatment consists of lifelong strict adherence to gluten‐free diet (GFD). However, there is a lack of evidence‐based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroenterology Hepatology, and Nutrition, supported by the Nutrition Committee and the Allied Health Professionals Committee, aims to present evidence‐based recommendations on the GFD as well as how to support dietary adherence.MethodsA wide literature search was performed using the MeSH Terms: “diet, gluten free,” “gluten‐free diet,” “diets, gluten‐free,” “gluten free diet,” and “coeliac disease” in Pubmed until November 8th, 2022.ResultsThe manuscript provides an overview of the definition of the GFD, regulations as basis to define the term “gluten‐free,” which foods are naturally gluten‐free and gluten‐containing. Moreover, it provides recommendations and educational tips and infographics on suitable food substitutes, the importance of reading food labels, risk of gluten cross‐contact at home and in public settings, nutritional considerations as well as factors associated to dietary adherence based on available evidence, or otherwise clinical expertise.ConclusionsThis position paper provides guidance and recommendations to support children with coeliac disease to safely adhere to a GFD.
Idiopathic fibrosing pancreatitis: A rare cause of obstructive jaundice
Authors: Huynh Mindy , Silva Rodolfo , Thiruvengadam Nikhil , Parashette Kalyan 
Published: January 2024

AbstractJaundice is an important physiologic manifestation of both benign and insidious diseases. We report on the case of an 11‐year‐old male who presented with diffuse pruritis, jaundice, and later abdominal pain. Initial work‐up revealed an obstructive cholestatic pattern, warranting investigation for structural anomalies. Extensive imaging revealed a lesion on the pancreatic head, and biopsy of the lesion confirmed the diagnosis of idiopathic fibrosing pancreatitis (IFP). Temporary stenting of the common bile duct successfully treated our patient's symptomatic IFP.
How to promote the construction of low‐carbon cities in China? An urban complex ecosystem perspective
Authors: Zhu Xiongwei , Li Dezhi 
Published: January 2024

AbstractThe escalation of carbon emissions has propelled global warming into a global issue requiring urgent attention. As primary contributors to global carbon emissions, cities constitute the central battleground for efforts aimed at carbon emission reduction. Notably, China, the world's largest carbon emitter, has channeled substantial human and financial resources towards the development of low‐carbon cities. However, the multifaceted challenges confronting Chinese low‐carbon city construction (LCC), including the lack of clearly defined construction strategies and deficiencies in government policy implementation, underscore the need for a systematic exploration of the influencing factors and mechanisms to overcome these obstacles. In response to this pressing need, this study utilizes a conceptual framework that is deeply rooted in the complex urban social‐economic‐natural‐management ecosystem. Within this framework, the study meticulously identified 12 influencing factors and, employing the pressure‐state‐response (PSR) model, categorized them to elucidate the dynamic and multidimensional nature of low‐carbon city construction. Subsequently, the DEMATEL method was employed to explore the causality and centrality of these 12 factors, and the ISM method was used to analyze the hierarchical structure and influencing factors and mechanisms of LCC. Three paths from LCC pressure to LCC response were established. Finally, three major implications were proposed to help Chinese LCC: (i) improve urban strategic planning applicability in a one‐city‐one‐policy manner, (ii) strengthen the green economy's long‐term development mechanism, and (iii) use the enthusiasm of market forces and public participation.
Seismic behavior of prefabricated frame with special‐shaped concrete‐filled steel tubular columns and H‐shaped steel beams
Authors: Zhang Yujie , Wang Lai , Dong Xitong , Xu Zhifeng , Guan Shangshang , Liu Liyuan , Chen Haitao 
Published: January 2024

AbstractTo realize the prefabricated structure of special‐shaped concrete‐filled steel tubular (CFST) column frame and enhance the level of indoor room utilization, this paper proposed a novel prefabricated frame with special‐shaped CFST columns and H‐shape steel beams connection with side plate. To investigate seismic behavior of this prefabricated frame structure, a 2‐story and 2‐bay CFST frame specimen was fabricated and tested under reversed cyclic loading. The failure mode, hysteresis behavior, degradation of lateral stiffness and bearing capacity, ductility and energy dissipation were analyzed. Experiment results indicated that failure mode presented strong columns and weak beams. Hysteresis curve of frame showed fully shuttle‐shaped. The mean story drift angle was 1/36 at ultimate stage. Equivalent viscous damping coefficient was 0.038–0.464. The bearing capacity degradation was relatively gentle, but the overall stiffness degradation was more obvious. It suggested that the frame had proper seismic and energy dissipation property. After the test, the seismic property of test frame was further investigated through the numerical simulation approach. The failure mode and skeleton curve obtained from the simulation were nearly consistent with test results, indicating that numerical analysis results were precise and with high reference meaning.
Use of chemotherapy in Syrian hamsters (Mesocricetus auratus) with epitheliotropic T‐cell lymphoma: Two cases (2021–2022)
Authors: Chan Shih Chieh , McDermott Colin T. , Wyre Nicole 
Published: January 2024

AbstractEpitheliotropic cutaneous T‐cell lymphoma (ETCL) is rarely described in golden or Syrian hamsters (Mesocricetus auratus), and no effective treatments or outcomes have previously been published. This study includes two cases of epitheliotropic cutaneous T‐cell lymphoma that were diagnosed via skin biopsy. Clinical presentation, diagnosis, treatment and outcome were reported. Both cases received chemotherapy, including prednisolone, lomustine, L‐asparaginase and chlorambucil. One Syrian hamster that received prednisolone (0.5 mg/kg per os every 24 hours) and chlorambucil (0.4 mg/kg per os every 24 hours) survived 276 days after diagnosis. Another Syrian hamster treated with prednisolone (1 mg/kg per os every 24 hours) survived 81 days after diagnosis. The effectiveness of lomustine and L‐asparaginase remains unknown for Syrian hamsters, and more studies are needed to determine appropriate dose ranges for chlorambucil. The combination of chlorambucil (0.4 mg/kg per os every 24 hours) and prednisolone (0.5–1 mg/kg per os every 24 hours) may assist in managing epitheliotropic cutaneous T‐cell lymphoma in Syrian hamsters.
Ocular canine transmissible venereal tumour: Report of three cases
Authors: Nuwanshika‐Naduni R. M. N. S. , Bandaranayake‐Nishadhi B. M. L. N. , De Silva‐Niranjala D. D. N. , Ariyarathna‐Harsha H. M. H. S. , Wijayawardhane‐Nayana K. A. N. 
Published: January 2024

AbstractThis study investigated three cases of transmissible venereal tumour in dogs. In Case 1, a 5‐year‐old male dog presented with an eye mass and penile growths, unresponsive to previous treatment. Case 2 involved a 4.5‐year‐old male dog with bilateral ocular masses and penile lesions. Case 3 featured a stray dog with ocular and skin masses. All cases were confirmed as transmissible venereal tumour through impression smear cytology. Treatment with vincristine sulphate resulted in significant remission, with complete recovery after the fourth injection. This study contributes valuable knowledge for veterinarians in diagnosing and treating transmissible venereal tumour in dogs, emphasising the significance of an approach to case management and careful consideration of the varying clinical manifestations of the disease.
Assesing the knowledge, perception, and attitude of wildlife management students toward biodiversity conservation in Nigeria
Authors: Ajayi Omolola O. , Coker Oluwakayode M. , Agbon Zion 
Published: January 2024

AbstractDespite intensified media campaigns and heightened emphasis on classroom instruction, recent international research has reported that young people are still failing to acknowledge biodiversity conservation as an issue of high priority. This study assessed students' knowledge, perception, and attitude toward biodiversity conservation in three Federal Universities offering Wildlife Management course in Southwestern Nigeria. A total of 159 respondents (15% sampling intensity) were surveyed using a structured questionnaire between July and December 2021. The findings revealed that most students had low knowledge of biodiversity conservation. This result is quite shocking given that they were enrolled in wildlife management courses. On the other hand, they had favorable attitudes and perceptions. The result further revealed that students in University of Ibadan had better attitude and perception. We concluded that there is a need to develop and teach programs and curricula that encourage and sustain the interests of wildlife students in biodiversity conservation.
Surveying the Effects of Aging a High C-Containing Co-Based Superalloy From the As-Cast and Solution Heat-Treated Conditions
Authors: Moffat James P. , Christofidou Katerina A. , Pek Ming En , Jones Nicholas G. , Jackson Paul , Stone Howard J. 
Published: January 2024

AbstractThe microstructure of the high carbon-containing cobalt-based superalloy, Co-101, has been studied in the as-cast state and following a variety of heat treatments. In the as-cast state both M7C3 and Mo-rich M23C6 carbides were observed in the interdendritic regions. After thermal exposure at temperatures between 1000 °C and 1250 °C for 1, 10, and 100 hours, the M7C3 interdendritic carbide network was observed to transform into a Mo-lean M23C6 carbide. These changes were rationalized with thermodynamic calculations. The carbide transformation liberated carbide-forming elements that resulted in the precipitation of intragranular carbides in the dendritic regions at temperatures below 1150 °C. These carbides in the cast-aged material preferentially formed at the dendrite peripheries early during exposure, leading to wide particle size distributions. Peak hardness in the cast-aged material was attained within the first 10 hours of exposure and softening was observed thereafter. After solution heat treating at 1250 °C for 10 hours, the microstructure of Co-101 comprised an M23C6 interdendritic carbide network and solid solution dendrites supersaturated with carbide-forming elements. Subsequent aging of this microstructure for 100 hours at 900 °C led to a high number density and narrow particle size distribution of intragranular carbides. The characteristics of these carbides in the solution-aged material resulted in greater hardness, which was retained for longer durations of exposure, than the cast-aged specimens.
Stein’s identities and the related topics: an instructive explanation on shrinkage, characterization, normal approximation and goodness-of-fit
Authors: Kubokawa Tatsuya 
Published: January 2024

AbstractThe Stein-type identities are widely recognized for their substantial utility and potency in deriving shrinkage estimators improving on crude estimators in normal, gamma, Poisson, and negative binomial distributions. Additionally, these identities serve to characterize these distributions themselves. The Stein identities are also used to demonstrate normal approximation. Moreover, they are instrumental in constructing statistical tests to assess the goodness-of-fit for normality, exponentiality, and Poissonity of distributions. This article offers an instructive and comprehensive explanation of the applications of Stein-type identities in the aforementioned contexts.
Investigation of thermomagnetic convective flow in vertical layers between water and kerosene based magnetic fluids
Authors: Rahman Md. Habibur , Hossain Md. Rakib , Mondal Sushmita , Rahman Hasibur 
Published: January 2024

AbstractIn this article, the convective flow in a vertical layer subjected to a consistent magnetic field with nonzero gravity condition is investigated. One side of the vertical walls is heated, while the opposite side is cooling. The magnetic field strength, field orientation angle, magnetization effect, and thermal deviation of vertical walls play important roles as controlling parameters on the flow stabilization. The goal of this investigation is to analyze the flow characteristics and find out the significant distinction between water and kerosene based magnetic fluids under the variation of thermal and magnetic effects. The numerical results are obtained by the pseudo-spectral Chebyshev expansion method. The properties of all instability modes caused by three major mechanisms, namely; thermomagnetic, thermogravitational and magneto-gravitational are analyzed. In the normal magnetic field, the wave speed responds faster, and it is recognized by a relatively small wave number in water based fluid than that in kerosene based fluid. In oblique magnetic field, the waves propagate faster in both kerosene and water based fluids with the field inclination angle increases, but they still propagate slower in kerosene based fluid comparatively in water based fluid. According to the linear or non-linear magnetization law, both upward and downward propagating waves in kerosene based fluid propagate slower, and they are recognized by greater wave numbers than that in water based fluid. It is found that the basic flow in water based fluid is much more stable than in kerosene based fluid.
Perspective/Commentary: The Transformation of STEMI Care with Thrombolysis in Paramedicine
Authors: Maria Sonja Jane 
Published: January 2024

AbstractThe integration of thrombolysis into paramedicine practice has brought about a significant paradigm shift in the treatment and prognosis of patients with STEMI (ST-Elevation Myocardial Infarction). This innovative approach has led to a notable increase in patient survival rates, demonstrating its effectiveness. A crucial aspect of this transformative change is the noteworthy reduction in “door-to-needle” time, a critical benchmark in STEMI management. As we delve deeper into examining this shift, it becomes increasingly evident that its impact extends beyond the immediate and convenient on-scene medical intervention. Instead, it fundamentally alters the trajectory of patient outcomes, highlighting the evolving role of paramedicine within the realm of medical care.