bluuebunny/crossref_metadata_2025_split huggingface dataset:
Completion thyroidectomy: A safe option for high‐volume surgeons
Authors: Issa Peter P. , Hossam Eslam , Cheng Jack H. , Magazine Brandon M. , Hussein Mohammad , Luo Xinyi , Abdelhady Ali , Staav Jonathan , LaForteza Alexandra , Albuck Aaron L. , Shama Mohamed , Toraih Eman , Kandil Emad 
Published: October 2023

AbstractBackgroundThe risk of complication in patients undergoing completion thyroidectomy (cT) is mixed. Several studies report increased risk in comparison to total thyroidectomy (TT) and still others reporting a comparatively decreased risk. We compared the rates of complication in patients at our institution undergoing thyroid lobectomy (TL), (TT), and cT by a single high‐volume surgeon.MethodsWe performed a single‐institution retrospective cohort study. Patients undergoing TL, TT, or cT by a high‐volume surgeon were included. Rates of complication were collected and compared between the three cohorts.ResultsA total of 310 patients were included. The overall rate of complication was 4.2%. The complication rates in the TL, TT, and cT cohorts were 1%, 7.1%, and 4.5%, respectively (p = 0.10). Transient hypocalcemia was slightly more common in the TT cohort (6.1%) as opposed to the TL (0%) or cT (0.9%) cohort (p = 0.01). The cohorts also had similar rates of recurrent laryngeal nerve signal loss leading to transient dysphonia (TL: 0% vs. TT: 1% vs. cT: 3.6%, p = 0.10).ConclusionsWhile rates of complication tended to predictably decrease as approaches became less extensive, there were no significant differences in complication rates among the three surgical approaches when performed by a high‐volume surgeon. Considering the low rates of complication overall, patient counseling and preference should be emphasized to provide appropriate and tailored treatment plans.
Transformation to diffuse large B‐cell lymphoma and its impact on survival in patients with marginal zone lymphoma: A population‐based study
Authors: Du Yu , Wang Ying , Li Qinlu , Chang Xiaona , Shen Kefeng , Zhang Heng , Xiao Min , Xing Shugang 
Published: October 2023

AbstractSome patients with marginal zone lymphoma (MZL) experience histological transformation to diffuse large B‐cell lymphoma (DLBCL). Because of the paucity of long‐term data on transformation, we conducted a population‐based study to estimate the risk of transformation and its impact on survival in MZL. Using the Surveillance, Epidemiology and End Results database, we identified 23 221 patients with histology‐proven MZL between 2000 and 2018. Competing risk method, Kaplan‐Meier and Cox proportional hazards regression were performed to analyze time‐to‐event outcomes. Based on 420 events of transformation, the 10‐year cumulative incidence rate of transformation is 2.23% (95% CI: 2.00%‐2.46%) in MZL, 1.5% (95% CI: 1.3%‐1.8%), 2.7% (95% CI: 2.3%‐3.2%) and 5.8% (95% CI: 4.6%‐7.1%) in extranodal, nodal and splenic MZL (EMZL, NMZL and SMZL), respectively. Patients with SMZL (subdistribution hazard ratio [SHR], 2.96; 95% CI: 2.21‐3.96) or NMZL (SHR, 1.49; 95% CI: 1.17‐1.90) have a higher risk of transformation than those with EMZL. For each MZL subtype, patients with transformation had a significantly shorter overall survival. Patients with transformation >18 months since MZL diagnosis had longer OS than those who presented within 18 months (5‐year rate, 87.4% [95% CI: 83.7%‐91.2%] vs 47.9% [95% CI: 38.8%‐59.0%]; P < .001). Compared to patients with matched de novo DLBCL, those whose DLBCL was transformed from MZL had a shorter OS (5‐year rate, 56.6% [95% CI: 51.9%‐61.8%] vs 46.1% [95% CI: 40.9%‐51.9%]; P < .001). We concluded that patients with SMZL had the highest risk of transformation. Regardless of MZL subtype, transformation resulted in significantly increased mortality.
Usefulness of a low‐cost simulation model for teaching internal manual aortic compression. A survey‐based mannequin evaluation
Authors: Nieto‐Calvache Albaro José , Otero Andy Felipe , Nieto‐Calvache Alejandro Solo , Aryananda Rozi , Ortiz‐Lizcano Edgar Iván , Meade‐Triviño Paulo , Maya Juliana , Sarria‐Ortiz Daniela , Muñoz‐Córdoba Laura , Yanque‐Robles Omar , Posadas Alejandro , Zea‐Prado Francisco , Burgos‐Luna Juan Manuel , Vasco Mauricio , Messa‐Bryon Adriana 
Published: October 2023

AbstractObjectiveTo evaluate the users' opinion on internal manual aortic compression (IMAC) training, using a low‐cost simulation model.MethodsAn educational strategy was designed to teach IMAC, which included: (1) guided reading of educational material and viewing an explanatory video of IMAC; (2) an introductory lecture with the anatomical considerations, documentation of the cessation of femoral arterial flow during IMAC, and real clinical cases in which this procedure was used; and (3) simulated practice of IMAC with a new low‐cost manikin. The educational strategy was applied during three postpartum hemorrhage workshops in three Latin American countries and the opinions of the participants were measured with a survey.ResultsAlmost all of the participants in the IMAC workshop, including the simulation with the low‐cost mannikin, highlighted the usefulness of the strategy (scores of 4/5 and 5/5 on the Likert scale) and would recommend it to colleagues.ConclusionWe present a low‐cost simulation model for IMAC as the basis of an educational strategy perceived as very useful by most participants. The execution of this strategy in other populations and its impact on postpartum hemorrhage management should be evaluated in further studies.
Looking back to light the path forward: Ghosts in the Nursery revisited
Authors: Slade Arietta 
Published: October 2023

AbstractThe infant health movement was launched nearly 50 years ago with the publication of the now classic paper, Ghosts in the Nursery: A psychoanalytic approach to the problems of impaired infant‐mother relationships, written by Selma Fraiberg, Edna Adelson, and Vivian Shapiro (1975). This paper offers us lessons for infant mental health practice that have been proven true time and again over the last 50 years. These lessons both underscore the factors essential to clinical progress across a range of interventions, and remind us of the significant challenges we face in these times of massive, global trauma and oppression, extreme economic hardship, and systemic racism. This commentary reviews the key lessons of Fraiberg and her colleagues’ classic paper, addresses some of the challenges inherent in retaining the breadth and substance of Fraiberg's model in contemporary practice, and proposes a model for conceptualizing infant and early childhood mental health practice that is geared toward building the relational foundations of reflection (Slade, 2023).
Penalized sieve estimation of zero‐inefficiency stochastic frontiers
Authors: Cai Jun , Horrace William C. , Parmeter Christopher F. 
Published: October 2023

SummaryStochastic frontier models for cross‐sectional data typically assume that the one‐sided distribution of firm‐level inefficiency is continuous. However, it may be reasonable to hypothesize that inefficiency is continuous except for a discrete mass at zero capturing fully efficient firms (zero‐inefficiency). We propose a sieve‐type density estimator for such a mixture distribution in a nonparametric stochastic frontier setting under a unimodality‐at‐zero assumption. Consistency, rates of convergence and asymptotic normality of the estimators are established, as well as a test of the zero‐inefficiency hypothesis. Simulations and two applications are provided to demonstrate the practicality of the method.
Protection of schisantherin A against dictamnine‐induced hepatotoxicity: Pharmacokinetic insights
Authors: Chang Xiaojin , Li Guangyao , Yang Bufan , Lin Dongju 
Published: October 2023

AbstractDictamnine (DIC), as the most abundant furoquinoline alkaloid ingredient of the herbal medicine Cortex Dictamni (CD), can induce severe liver injury. A previous study found that DIC‐induced liver injury was initiated by cytochrome P4503A (CYP3A)‐mediated metabolic activation and subsequent formation of adducts with cellular proteins. Schisantherin A (SchA) is the major lignan component of the herbal medicine Schisandra chinensis (SC). SC is frequently combined with CD used in numerous Chinese medicinal formulas for the treatment of eczema and urticaria. Furthermore, SC could protect against CD‐induced hepatotoxicity. The objective of the study was to investigate the protective effect of SchA on DIC‐induced hepatotoxicity based on pharmacokinetic interactions. The studies found that SchA exerted a protective effect on DIC‐induced hepatotoxicity in a dose‐dependent manner. Pharmacokinetic studies showed that pretreatment with SchA enhanced the area under concentration‐time curve (AUC) and maximal concentration (Cmax) values of DIC in the serum and liver tissue of mice, indicating that SchA could augment the accumulation of DIC in the circulation. In vitro metabolism assays with mouse liver microsomes (MLMs) showed that SchA reduced the production of DIC–glutathione (GSH) conjugate. In addition, SchA significantly reduced the excretion of DIC–GSH conjugate in the urine of mice and relieved hepatic GSH depletion induced by DIC. These results suggested that SchA could inhibit the metabolic activation of DIC in vitro and in vivo. In summary, our findings showed that the observed pharmacokinetic interactions might be attributable to the inhibition of the metabolism of DIC by SchA, which might be responsible for the protection of SchA against DIC‐induced hepatotoxicity. Therefore, the development of a standardized combination of DIC and SchA may protect patients from DIC‐induced liver injury.
The role of tocilizumab in the treatment of post‐transfusion hyperhaemolysis
Authors: Desai Naeem , Peters Jayne , Davies Elizabeth , Sharif Joseph 
Published: October 2023

AbstractHyperhaemolysis syndrome (HHS) is a serious complication of transfusion mostly reported in patients with sickle cell disease. HHS is characterised by the destruction of both donor and autologous red blood cells. Tocilizumab is a recombinant humanised monoclonal antibody that inhibits the binding of interleukin‐6 and has been used in the treatment of severe/critical coronavirus disease 2019 infection but also some cases of HHS. We describe two further cases of HHS successfully treated with tocilizumab and propose a decision aid for when to consider this treatment.
Characterization of the marine‐air intrusion Marinada in the eastern Ebro sub‐basin
Authors: Jiménez Maria A. , Grau Antoni , Martínez‐Villagrasa Daniel , Cuxart Joan 
Published: October 2023

AbstractThe eastern Ebro basin is composed of an extensive irrigated plain, surrounded by rainfed slopes and wooden mountain ranges and open to the west to the agricultural western Ebro basin. The sea breeze generated at the coast is able to surmount the Catalan prelitoral range through its lowest heights, reaching the basin by its easternmost part. It is a well‐known feature in the region, called Marinada. A network of Automatic Weather Stations is used here to analyse a period of 19 years (2003–2021). A filtering procedure is developed which selects the events when the Marinada is present, based on detecting clear sky, weak wind conditions and the wind direction from the coast in the afternoon. The analysis of these days show that the Marinada propagates along the basin in the afternoon meanwhile observations of the specific humidity show a sudden increase as the temperature cools down, resulting on a cold and humid advection. It is also found that the timing of the arrival of the Marinada depends on the mesoscale/synoptical circulations already present in the region (westerlies or a thermal low).
Characteristics of distal femoral articular cartilage in 6 weeks posttraumatic osteoarthritis by a subcritical impact
Authors: Mantebea Hannah , Singh Amanveer , Badar Farid , Abdelmessih Gabrielle , Sebastian Talia Marie , Baker Kevin , Newton Michael , Xia Yang 
Published: October 2023

AbstractTraumatized knee greatly contributes to osteoarthritis (OA) of the knee in young adults. To intervene effectively before the onset of severe structural disruption, detection of the disease at the early onset is crucial. In this study, we put together the findings for the detection of OA from the femoral knee joint cartilage of the rabbit at 6 weeks posttrauma. Articular cartilage samples are taken from the impacted and nonimpacted joints at 0 week (serving as the control group) and at 6 weeks posttrauma by minimal force. The samples were imaged using microscopic magnetic resonance imaging (µMRI) at 11.7 µm/pixel and polarized light microscopy (PLM) at 1 µm/pixel. In addition, an inductively coupled plasma ‐ optical emission spectrometry analysis was performed using the adjacent cartilage samples. The outcomes of this study demonstrate an increase in T2 values in 6 weeks samples compared to the 0 week samples by µMRI technique, indicating a general increase of tissue hydration within cartilage. PLM detects a decrease in the average thickness of the superficial zones in the posttraumatic osteoarthritis samples, significant in the impacted femurs. There was an average increasing trend of maximum retardation in the tide mark in comparison to the reported calcium concentration (mg/L) in impacted samples suggesting a possible rise in mineralization in the 6 weeks samples. Qualitatively, physical observation of the joint after 6 weeks showed signs of reddening in the anterior femur suggesting the disease process is a localized phenomenon. Through microscopic imaging, we are able to detect these changes at 6 weeks posttrauma qualitatively and quantitatively.
East African highland cooking banana: towards an efficient selection of hybrids with user‐preferred food quality traits
Authors: Nowakunda Kephas , Khakasa Elizabeth , Ceballos Hernan , Kenneth Akankwasa , Tumuhimbise Robooni , Bugaud Christophe , Asasira Moreen , Uwimana Brigitte , Bouniol Alexandre , Nuwamanya Ephraim , Forsythe Lora , Marimo Pricilla , Dufour Dominique , Tushemereirwe Wilberforce 
Published: October 2023

AbstractBACKGROUNDDeterminants of culinary qualities of East African highland cooking bananas (EAHCB) are not well known. This constrains the inclusion of user‐preferred traits in breeding. The present study aimed to quantify key indicators of user‐preferred characteristics to enable selection of acceptable hybrids.RESULTSQualitative characteristics that drive preference were big bunches (15–34 kg), long straight/slightly curved fingers (12–23 cm), yellowness and soft texture. Descriptive sensory analysis of the intensity of colour and texture the 23 genotypes revealed that landraces Kibuzi, Mbwazirume, Nakitembe and Mpologoma had higher intensity of yellowness and lower intensity of hardness (softer) and a low score (≤ 1.0) of astringency taste. A preference test showed that they had higher acceptability scores. Biochemical, instrumental and sensory data revealed correlations between sensory firmness and instrumental hardness (r = 0.5), sensory firmness and amylopectin (r = −0.54), suggesting that qualitative descriptions can be predicted by instrumental and biochemical indicators. Significant (P < 0.05) variations in amylose and total starch content were observed in different varieties. Moderate correlations between instrumental hardness and firmness in mouth (r = 0.55), cohesiveness and firmness in the mouth (r = 0.57), and adhesiveness and firmness in the mouth (r = 0.64) were observed. Surprisingly, carotenoids content was not correlated with yellowness in cooked matooke. However, positive correlations were observed between chroma (b*) parameters of raw matooke and sensorial assessed color on cooked samples.CONCLUSIONQualitative characteristis; the bunch, pulp colour and texture; that drive users‐preference in the EAHCB were quantified, paving way for breeders to use them to select genotypes with these attributes early in the breeding process. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The role of KDM4A‐mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis
Authors: Li Xi‐Xi , Xu Jia‐Kun , Su Wei‐Jie , Wu Hong‐Lin , Zhao Kun , Zhang Chang‐Ming , Chen Xiang‐Kun , Yang Li‐Xuan 
Published: October 2023

AbstractTemozolomide (TMZ) resistance presents a significant challenge in the treatment of gliomas. Although lysine demethylase 4A (KDM4A) has been implicated in various cancer‐related processes, its role in TMZ resistance remains unclear. This study aims to elucidate the contribution of KDM4A to TMZ resistance in glioma cells and its potential implications for glioma prognosis. We assessed the expression of KDM4A in glioma cells (T98G and U251MG) using qRT‐PCR and Western blot assays. To explore the role of KDM4A in TMZ resistance, we transfected siRNA targeting KDM4A into drug‐resistant glioma cells. Cell viability was assessed using the CCK‐8 assay and the TMZ IC50 value was determined. ChIP assays were conducted to investigate KDM4A, H3K9me3, and H3K36me3 enrichment on the promoters of ROCK2 and HUWE1. Co‐immunoprecipitation confirmed the interaction between HUWE1 and ROCK2, and we examined the levels of ROCK2 ubiquitination following MG132 treatment. Notably, T98G cells exhibited greater resistance to TMZ than U251MG cells, and KDM4A displayed high expression in T98G cells. Inhibiting KDM4A resulted in decreased cell viability and a reduction in the TMZ IC50 value. Mechanistically, KDM4A promoted ROCK2 transcription by modulating H3K9me3 levels. Moreover, disruption of the interaction between HUWE1 and ROCK2 led to reduced ROCK2 ubiquitination. Inhibition of HUWE1 or overexpression of ROCK2 counteracted the sensitization effect of si‐KDM4A on TMZ responsiveness in T98G cells. Our findings highlight KDM4A's role in enhancing TMZ resistance in glioma cells by modulating ROCK2 and HUWE1 transcription and expression through H3K9me3 and H3K36me3 removal.
Interannual variability of ground surface thermal regimes in Livingston and Deception islands, Antarctica (2007–2021)
Authors: de Pablo M. A. , Ramos M. , Vieira G. , Molina A. , Ramos R. , Maior C. N. , Prieto M. , Ruiz‐Fernández J. 
Published: October 2023

AbstractThe absence of vegetation in most ice‐free areas of Antarctica makes the soil surface very sensitive to atmosphere dynamics, especially in the western sector of the Antarctic Peninsula, an area within the limits of the permafrost zone. To evaluate the possible effects of regional warming on frozen soils, we conducted an analysis of ground surface temperatures (GSTs) from 2007 to 2021 from different monitoring sites in Livingston and Deception islands (South Shetlands archipelago, Antarctica). The analysis of the interannual evolution of the GST and their daily regimes and the freezing and thawing indexes reveals that climate change is showing impacts on seasonal and perennially frozen soils. Freezing Degree Days (FDD) have decreased while Thawing Degree Day (TDD) have increased during the study period, resulting in a balance that is already positive at the sites at lower elevations. Daily freeze–thaw cycles have been rare and absent since 2014. Meanwhile, the most common thermal regimes are purely frozen – F1 (daily temperatures < = −0.5°C), isothermal – IS (ranging between −0.5°C to +0.5°C), and purely thawed – T1 (> = +0.5°C). A decrease in F1 days has been observed, while the IS and T1 days increased by about 60 days between 2007 and 2021. The annual number of days with snow cover increased between 2009 and 2014 and decreased since then. The GST and the daily thermal regimes evolution point to general heating, which may be indicative of the degradation of the frozen soils in the study area.
Variation of the Omo Delta between 1990 and 2018: What remote sensing data reveal and models explain
Authors: Kangi Gladys , Dondeyne Stefaan , Kleinschroth Fritz , Van Orshoven Jos 
Published: October 2023

AbstractDeltas, being areas where river sediments accumulate, are sensitive to changes in climate and anthropogenic processes that affect sediment generation. The Omo Delta, on the Ethiopia–Kenya border, is constantly changing due to fluctuating lake levels, a variable climate, and rapidly changing land use. Due to field data scarcity and the region's limited accessibility, we relied on remote sensing (RS) data to investigate delta extent between 1990 and 2018 and attempted to disentangle the effect of climatic from anthropogenic variables. We obtained a time series of delta extent from Landsat imagery using Random Forest (RF) classification. Using parametric and non‐parametric regression techniques, we regressed the delta extent on Lake Turkana levels, Omo River discharges, Omo‐Gibe Basin rainfall, tree cover loss, and irrigation extent. The RF algorithm distinguished water from land with high (>90%) accuracies and revealed Omo Delta extent fluctuations ranging from 949 km2 in 1993 to 651 km2 in 2000. Lake water level, which depends on the rainfall over the Omo‐Turkana Basin, emerged as the best predictor of delta extent. However, the annual rainfall over the Omo‐Gibe Basin showed no correlation with delta extent. The regression models further show a connection between delta extent, irrigation extent, and tree cover loss. We conclude that rainfall indirectly influences delta extent across the Omo‐Turkana Basin. Regression models indicate additional cumulative effects of human activity in the Omo‐Gibe Basin but fall short in explaining delta dynamics.
An Empirical Comparison of Commonly Used Universal Rating Scales for Dystonia
Authors: Boz Deniz , Kilic‐Berkmen Gamze , Perlmutter Joel S. , Norris Scott A. , Wright Laura J. , Klein Christine , Bäumer Tobias , Löns Sebastian , Feuerstein Jeanne S. , Mahajan Abhimanyu , Wagle‐Shukla Aparna , Malaty Irene , LeDoux Mark S. , Ondo William , Pantelyat Alexander , Frank Samuel , Saunders‐Pullman Rachel , Jinnah H.A. 
Published: October 2023

ABSTRACTBackgroundThere are several widely used clinical rating scales for documenting the severity and distribution of various types of dystonia.ObjectivesThe goal of this study was to evaluate the performance of the most commonly used scales in a large group of adults with the most common types of isolated dystonia.MethodsGlobal Dystonia Rating Scale (GDRS) and the Burke‐Fahn‐Marsden Dystonia Rating Scale (BFM) scores were obtained for 3067 participants. Most had focal or segmental dystonia, with smaller numbers of multifocal or generalized dystonia. These scales were also compared for 209 adults with cervical dystonia that had Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores and 210 adults with blepharospasm that had Blepharospasm Severity Scale (BSRS) scores.ResultsThere were strong correlations between the GDRS and BFM total scores (r = 0.79) and moderate correlations for their sub scores (r > 0.5). Scores for both scales showed positive skew, with an overabundance of low scores. BFM sub‐scores were not normally distributed, due to artifacts caused by the provoking factor. Relevant sub‐scores of the GDRS and BFM also showed moderate correlations with the TWSTRS (r > 0.5) for cervical dystonia and the BSRS (r > 0.5) for blepharospasm.ConclusionsThe BFM is more widely used than the GDRS, but these results suggest the GDRS may be preferable for focal and segmental dystonias. The overabundance of very low scores for both scales highlights challenges associated with discriminating very mild dystonia from other abnormal movements or variants of normal behavior.