bluuebunny/crossref_metadata_2025_split huggingface dataset:
PECULIARITIES OF PAIN MANAGEMENT IN PATIENTS WITH GUNSHOT WOUNDS IN MEDICAL AND NURSING TEAMS
Authors: KUCHYN YU.L. , POSTERNAK G , GOVSEEV D.O. 
Published: October 2023

Summary. During the Anti-Terrorist Operation/Joint Forces Operation in eastern Ukraine, gunshot wounds account for about 74% of the casualties. Such injuries are accompanied by high intensity pain. At the stage of treatment in medical and nursing teams, effective pain management is important, because in the long term, more than 70% of these patients suffer from chronic pain. Therefore, studying the features of pain management at this stage of treatment can play an important role in improving the results of their treatment.
Objective. To study the peculiarities of pain treatment in patients after gunshot wounds at the stage of treatment in medical and nursing teams.
Methods. Study of patients with gunshot and mine-blast wounds. A visual analog scale was used to study the intensity of pain. The results of the study were analyzed using the EZR v.1.35 package (R statistical software version 3.4.3, R Foundation for Statistical Computing, Vienna, Austria). The Shapiro-Wilk, Mann-Whitney, Friedman, and Bonferroni correction criteria were used.
Results. The results of the study of 769 patients after gunshot wounds indicate that: 1) upon admission to the nursing teams (before anesthesia), the VAS pain intensity in group 1 was statistically different from group 2 (p<0.001) – in group 2, this indicator was higher; 2) the dynamics of VAS pain intensity during 2 days of observation shows no difference between the observation groups: 1 day – p=0.636, 2 days – p=0.465; 3) intervals between analgesia during the 1st day indicate a statistically significant difference between the groups (p=0.001), and on the 2nd day of observation no such difference was observed (p=0.818).
Conclusion. At the time of admission to the medical and nursing team, the pain intensity according to the VAS was 7-8 points, which meets the criteria for high intensity. This intensity of pain is likely to affect the chronicization of pain in the future. The number of injured anatomical areas of the body is important for determining the tactics of pain treatment in patients with gunshot wounds, because the intervals between the administration of painkillers indicate that those patients who were injured in 3 or more anatomical areas of the body more often needed the administration of painkillers.
MULTIMODAL LOW-OPIOID GENERAL ANESTHESIA FOR ELECTIVE CAESAREAN SECTION
Authors: PADALKO A. , DZIUBA D. 
Published: October 2023

Introduction: The frequency of general anaesthesia during caesarean section is up to 15 %. The main disadvantages of general anaesthesia during caesarean section are: a high percentage of consciousness during surgery and a pronounced hemodynamic reaction to surgical trauma. The most dangerous part of this surgical intervention is the period before the birth of a child.
Purpose: To compare the "routine" technique of total intravenous anaesthesia with artificial lung ventilation for elective caesarean section and multimodal low-opioid general anaesthesia.
Materials and methods: Our study is based on an examination of 60 patients. All patients were divided into 2 groups. The first group is a "routine" method of general anaesthesia, the second group is multimodal low-opioid general anaesthesia. Intravenous forms of medical drugs were used as adjuvants: paracetamol (1000 mg), clonidine (100 μg), 30 minutes before surgery and intravenous infusion of lidocaine (after the childbirth). Perioperative monitoring and treatment were based on the recommendations of the Enhanced Recovery After Caesarean Section and the American Association of Anaesthesiologists, the bispectral index and determination of the stress-induced substances (glucose, cortisol) blood levels were added. The newborns were evaluated with the Apgar scale and umbilical venous blood gas analysis was carried out. In the postoperative period, the intensity of pain, the time of patient activation and transfer from the intensive care unit were evaluated. The two-sided Student's t-test was used for statistical data processing (p value = 0.001; t > ± 3,466).
Results: The obtained data showed the presence of statistically significant differences between the two groups: mean blood pressure (t = 18.25); heart rate (t = 9.2); bispectral index (t = 5.9); assessment of newborns with the Apgar scale at 1 minute (t = - 4.2); parameters of umbilical venous blood gas analysis (t = - 6,5); glucose (t = 14.5); cortisol (t = 26,2); patient activation time (t = 8.12); the time of transferring from the intensive care unit (t = 8.67); pain assessment on a numerical rating scale (t = 13.4); using of opioids intraoperatively (t = 9.9); using of intravenous anaesthetics (t = 5.25); using of opioids after surgery (t = 8.78). Better indicators were determined in the multimodal low-opioid general anaesthesia group.
Conclusions: Based on the obtained results, the multimodal low-opioid general anaesthesia has reasonable (statistically significant) advantages over the "routine" technique of total intravenous anaesthesia with artificial lung ventilation for elective caesarean section.
Honeypot-as-a-Service dengan Kubernetes Cluster
Authors: Purwoko Rahmat , Priambodo Dimas Febriyan , Permana Ghiffari Adhe , Saptomo Wawan Laksito Yuly , Siswanti Sri , Hasbi Muhammad 
Published: October 2023

Honeypot merupakan salah satu strategi yang digunakan untuk melindungi jaringan dari serangan siber. Honeypot digunakan untuk menarik penyerang agar menyerang honeypot tersebut daripada perangkat-perangkat jaringan. Namun, penggunaan honeypot masih jarang terjadi di tingkat korporat maupun individu karena membutuhkan tenaga profesional dan infrastruktur khusus untuk mengelolanya selama implementasi. Berdasarkan permasalahan ini, peneliti mengusulkan solusi Software-as-a-Service (SaaS) yang disebut Honeypot-as-a-Service (HaaS). HaaS adalah layanan honeypot berbasis cloud yang dikelola oleh orkestrasi kontainer Kubernetes Cluster. Penggunaan Kubernetes Cluster dirancang untuk mengotomatiskan konstruksi, penjadwalan, pemeliharaan, dan penghapusan honeypot berkontainer. Otomatisasi ini dimaksudkan untuk membantu pelanggan yang ingin menggunakan sistem pertahanan berbasis honeypot dalam jaringan mereka tanpa harus menjalankan honeypot mereka sendiri. Pengguna dapat mendaftar akun dan mengonfigurasi honeypot menggunakan dashboard yang langsung terhubung ke cloud honeypot. Sistem ini sedang dikembangkan di lingkungan pusat data Departemen Keamanan Siber dari Politeknik Siber dan Sandi Negara, yang dikelola dengan manajemen virtualisasi Proxmox Virtual Environment. Komponen-komponen dari sistem HaaS terdiri dari honeypot di Kubernetes Cluster, HaaS-proxy, dan HaaS Dashboard. Sistem yang telah dibuat kemudian diuji availability, performance, functionality, and scenario. Hasil evaluasi sistem menunjukkan bahwa sistem HaaS membutuhkan pengembangan lebih lanjut. Meskipun ketersediaan dan performa sistem HaaS telah memenuhi kriteria layanan berbasis cloud, namun fungsionalitas sistem tidak memenuhi standar layanan SaaS secara umum. Namun, honeypot dibangun untuk memenuhi tujuan honeypot dalam menarik penyerang.
Tiftiğin Ankara’dan Silinişi (1880-1920)
Authors: KAYNAR İhsan Seddar 
Published: October 2023

Sanayi Devrimi öncesinde tekstil sektörünün en önemli hammaddelerinde biri olan tiftiğin üretim alanı Osmanlı İmparatorluğunun toprakları içinde yer alan Ankara Vilayetidir. Bir hammadde olarak tiftiğin, kırsalda hayvan yetiştiricileri ile başlayan iktisadi süreci, ipe dönüştürülmesi, iplerin renklendirilmesi, kumaşa dönüştürülmesi ve tezgahlarda gündelik kullanım malzemelerine dönüştürülmesini içeren uzun aşamaları barındırmaktadır.
Bir liman şehri olmamasına rağmen Ankara, 19.yy’ın sonuna kadar tiftik ürünlerinin ticaret merkezi olmuş, bu merkezde hakim ürün tiftik keçisi yetiştiriciliği olmuştur. İstanbul-Ankara Demiryolunun 1893 yılında faaliyete başlaması ile eş zamanlı olarak, bölgede hububat üretimi artmaya başlamış ve 1896 yılında hububat ihracı tiftik ihracını geçmiştir. 20.yy’ın ilk çeyreğinde Ankara çevresinde hayvancılıktan hububat üretimine hızlı bir geçiş yaşanmış; tiftik keçisi yetiştiriciliği önemini yitirmiştir. Demiryolunun gelişi, tiftiğin dış talebinden bağımsız olarak Anadolu’dan silinmesinde önemli bir aşamadır. Zamanla tiftik keçisi tür özelliklerine kaybetmeye başlamıştır. Birinci Dünya Savaşının başlaması ve Osmanlının dağılma sürecinin son aşaması olan Milli Mücadelenin en önemli savaşlarının 1919-1922 yılları arasında Ankara ve çevresinde gerçekleşmesi, tiftik açısından geri gidiş sürecinin son aşaması olmuştur.
Tiftik Türkiye’de ve Ankara’da silinirken, dünyada üretim alanları genişlemeye başlamıştır. Bu çalışmada Anadolu’nun kendi içsel dinamikleri ile başlayan tiftiğin gerileme süreci incelenecek ve tarımsal değişimin yereldeki dinamikleri ile uluslararası etkenlerin rolleri karşılaştırılacaktır. Önemli bir ihraç malı olarak tiftiğin Anadolu’da geçirdiği 40 yıllık dönüşüm İstanbul’daki Osmanlı Arşivinden ve Londra’daki İngiliz Arşivlerinden elde edilecek arşiv kaynakları ile açığa çıkarılmaya çalışılacaktır.
Immunological disorders in patients with mammary gland pathology in infertility associated with anovulation
Authors: Gladenko S.Е. , Netskar I.P. , Susidko O.M. , Kovalishin O.A. 
Published: October 2023

The objective: to study the state of the immune system in women with pathology of the mammary glands and infertility, and on the background of menstrual cycle disorders.Materials and methods. The research was performed in two stages. The first (1) stage included examination of women with infertility associated with anovulation who had breast pathology. These patients were divided into three groups: 1.1 group – 44 patients with diffuse fibrocystic breast disease (FBD), 1.2 group – 4 patients with fibroadenoma of the mammary glands, 1.3 group (control one) – 37 patients without pathological changes in the mammary glands.During the second (2) stage of the study, 110 women were examined: 2.1 group – 52 patients with regular menstruations and luteal phase insufficiency (LPI) and 2.2 group – 58 patients with anovulatory cycles.During two research stages, the immune status (CD3, CD4, CD8, immunoregulatory index (CD4/CD8), CD72, CD16, circulating immune complexes) and cytokine profile (IL-1, IL-2, IL-6, TNF-α, INF) in venous blood were determined. Differences were considered statistically significant at p<0.05.Results. A significant increase in the CD8 index was found in the group of patients with normal mammary glands (34.7±6.9 pg/ml; p<0.05) and with a diffuse form of FBD (35.13±6.9 pg/ml; p<0.05) versus its normal level in the group of patients with fibroadenoma (26.5±15.9 pg/ml; p>0.05).During the analysis of the CD16 level, it was determined its significantly increased to 18.8±3.1 pg/ml (р<0.05) in patients with LPI and regular menstrual cycle and to 26.3±4.8 pg/ml (р< 0.05) – in patients with anovulation without LPI, the difference between the groups was significant. The level of CD16 was significantly higher in anovulatory menstrual cycle disorder without LPI compared to patients with menstrual cycle disorder and LPI.The concentration of TNF-α in patients with a regular menstrual cycle (998.1±166.3 pg/ml; p<0.05) and with an anovulatory cycle without LPI (1029.3±187.1 pg/ml; p<0.05) was significantly higher compared to normal values (778.5±64.0 pg/ml). The level of IL-2 was significantly lower than normal indices. Thus, in the group of women with LPI, this indicator was 17.13±2.85 pg/ml (р<0.05), and by anovulation without LPI – 16.84±3.07 pg/ml (р<0.05) versus normal parameter 22.29±0.81 pg/ml.Conclusions. In patients with diseases of the mammary glands and infertility associated with anovulation without LPI, a significant decrease in the activity of T2-helpers (IL-2) and an increase in the activity of T1-helpers (TNF-α) were determined in cases of anovulation without LPI compared with cases of luteal phase insufficiency.
ANONİM ŞİRKETLERİN KAHRAMANMARAŞ MERKEZLİ DEPREMLERDEN SONRA YAPTIKLARI BAĞIŞLARA İLİŞKİN HUKUKİ DEĞERLENDİRMELER
Authors: KIRAN Süleyman 
Published: October 2023

Ülkemizde yaşanan Kahramanmaraş merkezli depremlerin oluşturduğu tahribat oldukça fazladır. İlan edilen olağanüstü hâl ile birlikte, kamu kurumları da anılan doğal afetlerin ortaya çıkardığı olumsuz sonuçların ortadan kaldırılmasına yönelik kendi çalışma alanlarına ilişkin olarak birtakım tedbirleri içeren kararlar almışlardır. Ancak alınan kararlar, olumsuz sonuçların ortadan kaldırılmasına yönelik daha çok pratik çözümler içeren kararlardır. Alınan kararların insan hayatını ve hayat mücadelesini doğrudan ilgilendirmesi sebebiyle toplumda çok fazla hukuka uygunluk değerlendirilmesine tabi tutulmamıştır.
İçlerinde bankaların ve hatta Türkiye Cumhuriyet Merkez Bankası’nın da bulunduğu anonim şirketler Kahramanmaraş merkezli depremlerden sonra aralarında yürütülen yardımlaşma ve dayanışma kampanyalarına yüksek miktarlarda bağışlar yapmışlardır. Bu durum, doktrinde çok fazla çalışma konusu yapılmayan anonim şirketlerin doğal afetlerin sonrasında yaptıkları bağışlara ilişkin hukuki değerlendirme yapılması gerekliliğini ortaya çıkarmıştır. Bu ihtiyaca binaen, çalışmamızda Kahramanmaraş merkezli depremlerden sonra getirilen düzenlemelere ilişkin hukuki değerlendirmeler yapılacaktır.
Çalışmamızda mevcut hukuki durum, ortaya çıkması muhtemel hukuki sorunlar ve çözüm önerilerimizi ortaya koymaya çalışacağız. Hukuki sorumluluk kısmı ise, çalışmanın hacmi gözetilerek bu çalışmanın kapsamının dışında bırakılmıştır.
DEVELOPING INTERCULTURAL COMPETENCE OF FUTURE GEOGRAPHY TEACHERS IN UKRAINIAN HIGHER EDUCATION INSTITUTIONS
Authors: Vishnikina Liubov , Hlukhota Vitalii 
Published: October 2023

Formation of intercultural competence in the modern world and contemporary conditions is a relevant scientific and pedagogical issue. The manifestation of modern integration processes leads to a change in perspectives on the necessity of tolerant relations among representatives of different cultures, religions, and viewpoints. Currently, within the context of international development, there is cultural exchange at personal, national, and international levels. Therefore, education has seen the emergence of a need for a culture of communication and cultural dialogue between different countries and their citizens. Considering multiculturalism and multi-ethnicity becomes a pedagogical priority for global civilization and nations. Adhering to it is an essential condition for democratizing civil society. The features of forming intercultural competence largely extend beyond pedagogy and depend on the influence of social and political institutions, but higher education institutions are the very establishments that can help shape a new multicultural, democratic, and civic society.The problem of forming intercultural competence is particularly pertinent for future geography teachers. Precisely, the prospective geography teacher should become a multicultural individual who will shape a tolerant, multicultural, conscious, and civic society in our nation. The article delves into the specifics of forming intercultural competence in higher education institutions, using the example of analyzing educational programs for the specialization “Secondary Education. Geography”. An analysis of scientific literature is conducted to systematize information about the particularities of cultivating multiculturalism in future educators. Researchersʼ viewpoints regarding the implementation specifics of intercultural competence in the educational process are scrutinized. The educational programs of five pedagogical universities are characterized in terms of the place of intercultural competence in the preparation of future geography teachers.
Keywords: educational program; professional training; general competencies; professional competencies; multiculturalism; intercultural competence; teacher; geography.
β-TCP from 3D-printed composite scaffolds acts as an effective phosphate source during osteogenic differentiation of human mesenchymal stromal cells
Authors: Hatt Luan P. , van der Heide Daphne , Armiento Angela R. , Stoddart Martin J. 
Published: October 2023

Introduction: Human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are often combined with calcium phosphate (CaP)—based 3D-printed scaffolds with the goal of creating a bone substitute that can repair segmental bone defects. In vitro, the induction of osteogenic differentiation traditionally requires, among other supplements, the addition of β-glycerophosphate (BGP), which acts as a phosphate source. The aim of this study is to investigate whether phosphate contained within the 3D-printed scaffolds can effectively be used as a phosphate source during hBM-MSC in vitro osteogenesis.Methods: hBM-MSCs are cultured on 3D-printed discs composed of poly (lactic-co-glycolic acid) (PLGA) and β-tricalcium phosphate (β-TCP) for 28 days under osteogenic conditions, with and without the supplementation of BGP. The effects of BGP removal on various cellular parameters, including cell metabolic activity, alkaline phosphatase (ALP) presence and activity, proliferation, osteogenic gene expression, levels of free phosphate in the media and mineralisation, are assessed.Results: The removal of exogenous BGP increases cell metabolic activity, ALP activity, proliferation, and gene expression of matrix-related (COL1A1, IBSP, SPP1), transcriptional (SP7, RUNX2/SOX9, PPARγ) and phosphate-related (ALPL, ENPP1, ANKH, PHOSPHO1) markers in a donor dependent manner. BGP removal leads to decreased free phosphate concentration in the media and maintained of mineral deposition staining.Discussion: Our findings demonstrate the detrimental impact of exogenous BGP on hBM-MSCs cultured on a phosphate-based material and propose β-TCP embedded within 3D-printed scaffold as a sufficient phosphate source for hBM-MSCs during osteogenesis. The presented study provides novel insights into the interaction of hBM-MSCs with 3D-printed CaP based materials, an essential aspect for the advancement of bone tissue engineering strategies aimed at repairing segmental defects.
Three decades of glacial lake research: a bibliometric and visual analysis of glacial lake identification
Authors: Liu Zhengquan , Yang Zhiquan , He Na , Wei Lai , Zhu Yingyan , Jiao Wenqi , Wang Zhengxian , Zhang Tao , Zhang Jiantao , Zou Xiang 
Published: October 2023

IntroductionAs a vital component within glacier systems, the occurrences of glacial lake disasters in high mountain regions have progressively emerged as one of the most destructive natural calamities amid the backdrop of global warming. The swift advancement of glacial lake identification techniques offers a pivotal perspective for forecasting and mitigating the perils of glacial lake outburst disasters.MethodsTo evaluate the thematic evolution, research focal points, and forthcoming directions within the glacier identification domain, a comprehensive bibliometric analysis was conducted on glacial lake identification-related literature from 1991 to 2023 in the Web of Science Core Collection database.Results1) The United States, the United Kingdom, and China stand as principal nations propelling the field's advancement. The Chinese Academy of Sciences demonstrates the highest activity in terms of article publications and international collaborations. 2) Climate change, compilation of glacial lake inventories, methodologies for risk assessment, glacial lake outburst floods, comprehensive disaster management strategies, and hydrodynamic models constitute the domain's research hotspots. It is a typical multidisciplinary field. 3) Persistently high-impact topics over an extended period include “hazard”, “Late Pleistocene”, “environmental change”, “ice sheet”, and “lake sediments”. Keywords indicating the present cutting-edge research encompass “inventory”, “glacial lake outburst flood”, “risk”, “dynamics”, “Tibetan Plateau”, “evolution”, and “high mountain Asia”.DiscussionThis paper delves into the current status and pivotal concerns of glacial lake identification techniques, methodologies, and the scale of identification research themes. Further Research should concentrate on avenues like “recognition methods grounded in machine learning and deep learning”, “multisource data fusion datasets”, “novel algorithms and technologies adaptable to scale transformation and data expansion”, as well as “enhancing spatiotemporal data resolution”. This will ultimately enable precise, prolonged, and multiscalar identification of glacial lakes. his study provides valuable guidance and reference for future research in the field of glacial lake identification.
Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds
Authors: Minias Piotr , Edwards Scott V. , Babik Wiesław 
Published: October 2023

IntroductionThe Major Histocompatibility Complex (MHC) of vertebrates is a dynamically evolving multigene family primarily responsible for recognizing non-self peptide antigens and triggering a pathogen-specific adaptive immune response. In birds, the MHC was previously thought to evolve via concerted evolution with high degree of gene homogenization and the rapid loss of orthology. However, the discovery of two ancient avian MHC-IIB gene lineages (DAB1 and DAB2) originating before the radiation of extant birds indicated that despite the action of concerted evolution, orthology may be detectable for long evolutionary periods.MethodsHere, we take advantage of rapidly accumulating digital genomic resources to search for the signal of an ancient duplication at the avian MHC-IIA genes, as well as to compare phylogenetic distribution and selection between MHC-IIA and IIB gene lineages.ResultsThe analysis of MHC sequences from over 230 species representing ca. 70 bird families revealed the presence of two ancient MHC-IIA gene lineages (DAA1 and DAA2) and showed that their phylogenetic distribution matches exactly the distribution of DAB1 and DAB2 lineages, suggesting tight coevolution. The early post-duplication divergence of DAA1 and DAA2 was driven by positive selection fixing radical amino acid differences within the membrane-proximal domain and, most probably, being functionally related to the interactions between α2 and β2 chains of the MHC-II heterodimer. We detected no evidence for an overall (gene-wide) relaxation or intensification of selection at either DAA1/DAB1 or DAA2/DAB2, but codon-specific differences in selection signature were found at the peptide-binding sites between the two gene lineages, perhaps implying specialization to different pathogen regimes.DiscussionOur results suggest that specific pairing of MHC-II α and β chains may have an adaptive significance, a conclusion that advances knowledge on the macroevolution of the avian MHC-II and opens exciting novel directions for future research.