bluuebunny/crossref_metadata_2025_split huggingface dataset:
HECTOR: multimodal deep learning predicts recurrence risk in endometrial cancer
Authors: Fremond-Volinsky Sarah , Horeweg Nanda , Andani Sonali , Wolf Jurriaan Barkey , Lafarge Maxime W , de Kroon Cor , Ørtoft Gitte , Høgdall Estrid , Dijkstra Jouke , Jobsen Jan J , Lutgens Ludy CHW , Powell Melanie E , Mileshkin Linda R , Mackay Helen , Leary Alexandra , Katsaros Dionyssios , Nijman Hans W , de Boer Stephanie M , Nout Remi A , de Bruyn Marco , Church David , Smit Vincent THBM , Creutzberg Carien L , Koelzer Viktor H , Bosse Tjalling 
Published: November 2023

AbstractPredicting distant recurrence of endometrial cancer (EC) is crucial for personalized adjuvant treatment. The current gold standard of combined pathological and molecular profiling is costly, hampering implementation. We developed HECTOR (Histopathology-basedEndometrialCancerTailoredOutcomeRisk), a multimodal deep learning prognostic model using hematoxylin-and-eosin-stained whole-slide-images and tumor stage as input, on 1,912 patients from seven EC cohorts including the PORTEC-1/-2/-3 randomized trials. HECTOR demonstrated C-indices in internal (n= 353) and external (n= 151) test sets of 0.788 and 0.816 respectively, outperforming the current gold-standard, and identified patients with markedly different outcomes (10-year distant recurrence-free probabilities of 97.0%, 77.7% and 58.1% for HECTOR low, intermediate and high risk groups). HECTOR also predicted adjuvant chemotherapy benefit better than current methods. Morphological and genomic feature extraction identified correlates of HECTOR risk groups, some with therapeutic potential. HECTOR improves on the current gold-standard and may help delivery of personalized treatment in EC.
A population genomics approach to unlock the genetic potential of lablab (Lablab purpureus), an underutilized tropical forage crop
Authors: Teshome A. , Habte E. , Cheema J. , Mekasha A. , Lire H. , Muktar M.S. , Quiroz-Chavez J. , Domoney C. , Jones C.S. 
Published: November 2023

AbstractBackgroundIn Sub-Saharan Africa (SSA) livestock production and productivity are severely restricted by the scarce supply of feedstuffs and forage crops, while those available are often of low nutritional quality resulting in poor animal productivity and leading to widespread malnutrition among the public, particularly women and children. Traditionally, several tropical forage crops have been used in the region both in the rangelands and as cut-and-carry cropping systems, but limited research attention has been paid to improve the quality of and access to these animal feeds. Lablab (Lablab purpureus(L.) is one of the conventionally grown multi-purpose underutilized crops that originated in Africa. It is an annual or short-lived perennial multi-purpose forage legume which has versatile uses (as a vegetable and dry seed), and as feed for animals, or as green manure. To develop new and highly productive lablab varieties, using genomics-assisted selection, the present study aimed to identify quantitative trait loci (QTL) associated with agronomically important traits in lablab and to assess the stability of these traits across two different agro-ecologies in Ethiopia.ResultsOne hundred and forty-two cultivated and wild lablab accessions displayed significant agro-morphological variation in eight analysed traits, including plant height, total fresh weight, and total dry weight. Further, the agronomic performance of the accessions was significantly different across locations and years, highlighting the substantial genotype-by-environment interactions. The population genetic structure of the lablab accessions, based on half a million high quality single nucleotide polymorphisms (SNPs), revealed an independent domestication pattern for two-seeded and four-seeded lablab accessions. Furthermore, based on multi-environmental trial data, a genome-wide association study (GWAS) identified useful SNPs andk-mers for yield-related traits, such as plant height and total dry weight.ConclusionsGenomic-assisted breeding is playing a key role in accelerating trait improvement in temperate forages, such as perennial ryegrass and alfalfa. Here we show that a similar approach could benefit underutilized crops such as lablab. The publicly available genomic tools and field evaluation data from this study will offer a valuable resource for plant breeders and researchers, to initiate genomic-assisted breeding in lablab which will fast-track genetic gain per unit time and ultimately contribute towards achieving food/nutritional security in the region.
Aging impairs skeletal muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution via fibro-adipogenic progenitors
Authors: Garcia-Carrizo Francisco , Gohlke Sabrina , Lenihan-Geels Georgia , Jank Anne-Marie , Leer Marina , Soultoukis George A. , Oveisi Masoome , Herpich Catrin , Garrido Claudia A. , Kotsaris Georgios , Pöhle-Kronawitter Sophie , Tsamo-Tetou Arnold , Graja Antonia , Ost Mario , Villacorta Laura , Knecht Raphael S. , Klaus Susanne , Schürmann Annette , Stricker Sigmar , Schmidt-Bleek Katharina , Cipitria Amaia , Duda Georg N. , Benes Vladimir , Müller-Werdan Ursula , Norman Kristina , Schulz Tim J. 
Published: November 2023

SummarySkeletal muscle regeneration depends on the function of fibro/adipogenic progenitors (FAPs). Here we show that aging impairs myogenic stem cells by disrupting the integration of extracellular matrix and immunomodulatory functions within the stem cell niche, thereby promoting fibro/fatty degeneration. We identify the FAP-secreted protein Periostin as a niche factor that is decreased in aged muscle and in circulation of aged humans with low-exercise lifestyle. Periostin controls FAP-expansion after injury and its depletion fate-regulates FAPs towards adipogenesis. This leads to delayed pro- to anti-inflammatory macrophage transition during regeneration. Transplantation of young FAPs with high Periostin secretion, but not Periostin-deficient FAPs, into aged muscle restores inflammation resolution and successful regeneration. Mechanistically, Periostin activates Focal adhesion kinase- and AKT-signaling in macrophages via integrins to promote an anti-inflammatory profile, which synchronizes matrix-derived mechanosensory signaling and immunomodulation. These results uncover a novel role of FAP-based regulation that orchestrates successful muscle regeneration and prevents fibro/fatty degeneration.
Genetically-clustered antifungal phytocytokines and receptor proteins function together to trigger plant immune signaling
Authors: Lintz Julie , Goto Yukihisa , Bender Kyle W. , Bchini Raphaël , Dubrulle Guillaume , Cawston Euan , Zipfel Cyril , Duplessis Sebastien , Petre Benjamin 
Published: November 2023

SummaryPhytocytokines regulate plant immunity via cell-surface receptors.Populus trichocarpaRUST INDUCED SECRETED PEPTIDE 1 (PtRISP1) exhibits an elicitor activity in poplar, as well as a direct antimicrobial activity against rust fungi.PtRISP1gene directly clusters with a gene encoding a leucine-rich repeat receptor protein (LRR-RP), that we termed RISP- ASSOCIATED LRR-RP (PtRALR).In this study, we used phylogenomics to characterize the RISP and RALR gene families, and functional assays to characterize RISP/RALR pairs.BothRISPandRALRgene families specifically evolved in Salicaceae species (poplar and willow), and systematically cluster in the genomes. Two divergent RISPs, PtRISP1 andSalix purpureaRISP1 (SpRISP1), induced a reactive oxygen species (ROS) burst and mitogen- activated protein kinases (MAPKs) phosphorylation inNicotiana benthamianaleaves expressing the respective clustered RALR. PtRISP1 triggers a rapid stomatal closure in poplar, and both PtRISP1 and SpRISP1 directly inhibit rust pathogen growth.Altogether, these results suggest that plants evolved phytocytokines with direct antimicrobial activities, and that the genes coding these phytocytokines co-evolved and physically cluster with their cognate receptors.
Investigating social communication in mice: a Two-intruders test approach
Authors: Morozova Maryana V. , Boldyreva Lidiya V. , Borisova Maria A. , Kozhevnikova Elena N. 
Published: November 2023

AbstractUnderstanding the complex dynamics of social communication behaviors, such as exploration, communication, courtship, mating, and aggression in animal models is crucial to reveal key neural and hormonal mechanisms underlying these behaviors. The Two-intruders test is designed to investigate residents’ behavior toward a male and female intruders. During this test imitating natural conditions, several aspects of social interaction were investigated: exploration, courtship, mating, and aggressive behavior. As mating and aggression involve overlapping neural circuits, the behavioral setup testing both behaviors is best at reflecting their competitive nature. Our findings demonstrate that male mice exhibit strong preference to communicate with a female intruder, which correlates with baseline testosterone levels of test males. Relevant female preference in the Two-intruder test was also found in BALB/c males. Behavioral breakdown revealed the anogenital sniffing as a key behavioral feature that discriminates test male behavior toward intruders of different genders. At the same time, female preference was accompanied by neuronal activation in the ventromedial hypothalamus. We demonstrate that odor recognition underlies preference toward females in male residents, as experimental anosmia reduced communication with a female intruder. However, there was no correlation between female animal preference in the contact Two-intruder test and smell preference in the social odor preference test. We assume the Two-intruders test setup to be a useful tool to study the neurological basis of social communication in animal models. Combined with odor preference tests, this experimental paradigm can help to decipher neural circuits involved in social deficiency phenotypes in animal models of human diseases.Significance StatementThe Two-intruders test proves to be a highly reproducible and robust approach to assess social communication in mice. We demonstrate that the results obtained in this experimental setting replicate in different mouse groups and strains. This test is indispensable in studies assessing the competitive nature of male- and female-driven behaviors and the underlying neural mechanisms. Resident’s social interactions in the described here set up reflects odor processing and circulating testosterone – the key physiological drivers of animal communication with conspecifics. While easy to perform, this test provides a broad spectrum of behavioral patterns to study in the models of complex neurological diseases. Largely overseen in the literature as compared to the resident-intruder setup, the Two-intruders test can provide superior performance when used to understand the neural mechanisms of mating, aggression and social communication.
Assessing language impoliteness of primary school teachers in Indonesia
Authors: Yusri Yusri , Mantasiah R. , Anwar Muhammad 
Published: November 2023

PurposeThis study investigated the use of language impoliteness of primary school teachers in communicating with their students during the learning process.Design/methodology/approachThe methodology of this study used a mixed-method approach by involving 100 primary school teachers in the fifth and sixth grades. The researcher used the language politeness/impoliteness scale developed by Mantasiah et al. (2019) to measure teachers' language impoliteness. This scale was developed based on Brown and Levinson's theory who divided politeness maxims into six consisting of tact maxim, generosity maxim, approbation maxim, appreciation maxim, agreement maxim and sympathy maxim. The levels of teachers' language impoliteness were divided into five categories (5 = always, 4 = often, 3 = sometimes, 2 = rarely, 1 = never).FindingsThe finding shows that 28% of teachers were in the sometimes category and 33% of teachers were in the rarely category. The results signify that some teachers tend to speak impolitely with the students during the learning process. They considered that it was acceptable as they did not know the negative effects caused by their impolite language. Moreover, teachers were more likely to violate sympathy, tact and agreement maxims than other maxims.Practical implicationsThe finding of this study can be applied generally at all levels of education, ranging from primary education to higher education, as a base to develop a program to improve the soft skills of teachers especially the way teachers communicate with their students in the learning process. By understanding language politeness theory, the awareness of teachers in communicating in the learning process can be improved, which can affect positively to the quality of learning process.Originality/valueNumerous studies conducted on communication skills of teachers focused on using communication sciences approach. This study tried to use another approach to portray the communication skills of teachers based on language politeness uttered using linguistics approach. Moreover, previous studies preferred to conduct language politeness and impoliteness of teachers in senior high schools and lecturers in university, and there is still lack of studies focusing on language politeness of primary school teachers.
Circular supply chain valorisation through sustainable value mapping in the post-consumer used clothing sector
Authors: Pal Rudrajeet , Sandberg Erik 
Published: November 2023

PurposeThe purpose of this study is to explore the antecedents of uncaptured sustainable value and strategies to generate opportunities to capture it in the circular supply chain of post-consumer used clothing.Design/methodology/approachThis study is based on an inductive analysis of 21 semi-structured interviews conducted with various stakeholders in the circular clothing supply chain (for-profit and not-for-profit) using the value mapping approach, as previously applied in the literature on sustainable business models.FindingsFifteen antecedents of uncaptured sustainable value, and thirteen value opportunity strategies were revealed that hinder or generate multi-dimensional value types. Economic value is impacted the most, while there is lack of explicit understanding of the impact of these antecedents and strategies on environmental and social value capture. From a multi-stakeholder perspective, the ecosystem is emerging as new for-profit actors are developing novel process technologies, while not-for-profit actors are consolidating their positions by offering new service options. There is also an emerging “coopetition” between the different stakeholders.Research limitations/implicationsMore granularity in the different types of uncaptured value could be considered, and external supply chain stakeholders, such as the government, could be included, leading to more detailed value mapping.Practical implicationsThis research provides practitioners with a value-mapping tool in circular clothing supply chains, thus providing a structured approach to explore, analyse and understand uncaptured value and value opportunities.Originality/valueThis extended value perspective draws upon the value-mapping approach from the sustainable business model literature and applies it in the context of the circular clothing supply chain. In doing so, this research illustrates circular clothing supply chains in a new way that facilitates an improved understanding of multi-dimensional and multi-stakeholder value for embedded actors.
Logistics outsourcing to provide supply chain agility in crisis time: an action research
Authors: Benatiya Andaloussi Manal 
Published: November 2023

Purpose
The aim of this research is to underscore the pivotal role of warehouse management in the current turbulent global landscape exacerbated by the confluence of a health crisis and geopolitical instability in Europe. In today's interconnected global economy, the turbulence of the global supply chain causes a lack of its resilience among companies. Facing this critical crisis context, companies are refocusing on business processes and outsourcing support processes such as logistics. In this paper we have empirical and methodological objectives. Methodologically, we employ a qualitative research approach utilizing action research in a collaborative framework that involves academics and practitioners. The purpose of this methodology is to empirically investigate warehouse outsourcing as a solution for enhancing a company's performance and agility within the crisis context.

Design
The authors’ action research based on case study approach is conducted through an immersion within the ALCL French multinational company located in Morocco. The authors mobilize the theory of constraints, which allows us to set up a process of identification and optimization of managerial constraints (Goldratt, 1990). The approach allows to set up a retroactive loop to increase the performance of the constraint.

Findings
The study shows that ALCL has a storage over-dimension constraint due to the decrease of physical flows caused by the global crisis. The results of action research protocol show that the optimization of warehousing constraint is achieved by the total outsourcing of the process.

Originality
The study provides new insights into how action research can improve management practices within companies and explore concrete solutions to the logistical challenges faced by businesses.
Forgotten classics: Principles of Merchandising by Melvin T. Copeland (1924)
Authors: Shaw Eric H. , Liu Walter 
Published: November 2023

Purpose
The purpose of this paper is to show that forgotten classics, such as Melvin T. Copeland’s (1924) Principles of Merchandising, can still teach lessons to students of the history of marketing thought.

Design/methodology/approach
The method involved using various key words on several internet search engines. The extensive internet search produced more than a dozen contemporaneous reviews and commentaries. Additionally, there was an intensive search through the histories of marketing thought literature. The extensive and intensive searches allowed a meta-analysis reexamining Copeland’s principles in light of future historical developments from the mid-1920s to the 21st century.

Findings
Historically, Copeland’s principles established the commodity school of marketing thought. (One of the three traditional approaches to understanding marketing taught to generations of students from the mid-1920s until the mid-1960s.) Although the traditional approaches/schools have long gone out of favor, Copeland’s classification of consumer and industrial (business) goods (products and services) have stood the test of time and are still in use 100 years later. Long overlooked, Copeland’s (1924) Principles of Merchandising also anticipated the marketing management/strategy as well as the consumer/buyer behavior schools of marketing thought, dominant in the discipline since the 1960s, for which he has seldom – if ever – been acknowledged.

Research limitations/implications
Historical research is limited because some relevant source material may no longer exist or may have been overlooked.

Originality/value
There have been no reviews of Copeland’s principles in almost a century, and no published meta-analysis of this forgotten classic exists. New discoveries reveal the value in studying marketing history and the history of marketing thought. For marketing as a social science to progress, it is invaluable to understand how ideas originated, were improved and integrated into larger conceptualizations, classification schema and theories over time.
SDG commentary: service ecosystems with the planet - weaving the environmental SDGs with human services
Authors: Teixeira Jorge Grenha , Gallan Andrew S. , Wilson Hugh N. 
Published: November 2023

Purpose
Humanity and all life depend on the natural environment of Planet Earth, and that environment is in acute crisis across land, sea and air. One of a set of commentaries on how service can address the UN’s sustainable development goals (SDGs), the authors focus on environmental goals SDG 13 (climate action), SDG 14 (life below water) and SDG 15 (life on land). This paper aims to propose a conceptual framework that incorporates the natural environment into transformative services.

Design/methodology/approach
The authors trace the evolution of service thinking about the natural environment, from a stewardship perspective of the environment as a set of resources to be managed, through an acknowledgement of nonhuman organisms as actors that can participate in service exchange, towards an emergent concept of ecosystems as integrating human social actors and other biological actors who engage fully in value co-creation.

Findings
The authors derive a framework integrating human and other life forms as co-creating actors, drawing on shared natural resources to achieve mutualism, where each actor can have a net benefit from the relationship. Future research questions are posited that may help services research address SDGs 13–15.

Originality/value
The framework integrates ideas from environmental ecosystem literature to inform the nature of ecosystems. By integrating environmental actors and ecological insights into the understanding of service ecosystems, service scholars are well placed to make unique contributions to the global challenge of creating a sustainable future.
After the ‘Black Summer’ fires: Faunal responses to megafire depend on fire severity, proportional area burnt and vegetation type
Authors: Miritis Vivianna , Dickman Chris R. , Nimmo Dale G. , Doherty Tim S. 
Published: November 2023

Abstract

Climate change and human activities have disrupted historical fire regimes, leading to complex and far‐reaching impacts on global ecosystems. Despite extensive research in fire ecology, studies exploring vertebrate responses to megafires, and to nuanced fire characteristics, remain limited.

We collected camera trap data 3–27 months following Australia's 2019–20 ‘Black Summer’ megafires from 30 burnt sites and 10 unburnt sites. Our data included 14 animal species/groups, encompassing mammalian predators, small and medium‐sized mammals, large herbivores, and birds. We used generalised additive mixed models to assess the influence of time‐since‐the‐fires, burn status, fire severity, proportional area burnt, and vegetation type on species' activity.

Models that included fire variables were well‐supported for all species. The proportional cover of low‐moderate or high‐extreme severity fire had substantial support for five species, particularly herbivores, which generally showed a preference for burnt sites but at differing fire severities. The proportional area burnt, disregarding severity, was well supported for four species. At highly burned sites fox activity peaked shortly after the fires while small to medium‐sized mammal activity increased more gradually. Vegetation type strongly influenced the response of four species to fire; in particular, wet forest birds preferred unburnt areas.

Policy implications. We document variable short‐ to medium‐term responses of a range of species to fire which could help guide management interventions. We demonstrate that animal species' responses to fire are diverse and better captured using broader landscape scale fire variables. We found that species were strongly influenced by proportional area burnt, fire severity and vegetation type. Introduced foxes were attracted to recently burnt areas, so timely predator control may benefit vulnerable prey species. Wet forest species were sensitive to fires and could benefit from preservation and restoration of these habitats. Some species exploited low‐moderate severity burnt areas, while others preferred high‐severity burns. This suggests that species will face diverse challenges and opportunities in future extreme fire events. We emphasise the importance of using multi‐faceted approaches to account for the complex responses of co‐occurring species to fire events.