bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular and renal diseases in type 2 diabetes patients: 5-year cumulative incidence of the first occurred manifestation and hospitalization cost: a cohort within the French SNDS nationwide claims database
Authors: Blin Patrick , Joubert Michael , Jourdain Patrick , Zaoui Philippe , Guiard Estelle , Sakr Dunia , Dureau-Pournin Caroline , Bernard Marie-Agnès , Lassalle Régis , Thomas-Delecourt Florence , Bineau Sébastien , Moore Nicholas , Droz-Perroteau Cécile 
Published: January 2024

Abstract
Background
Myocardial infarction (MI), stroke, peripheral arterial disease (PAD), heart failure (HF) and chronic kidney disease (CKD) are common cardiovascular renal diseases (CVRD) manifestations for type 2 diabetes. The objective was to estimate the incidence of the first occurring CVRD manifestation and cumulative hospitalization costs of each CVRD manifestation for type 2 diabetes without CVRD history.

Methods
A cohort study of all type 2 diabetes free of CVRD as of January 1st 2014, was identified and followed-up for 5 years within the French SNDS nationwide claims database. The cumulative incidence of the first occurring CVRD manifestation was estimated using the cumulative incidence function, with death as a competing risk. Cumulative hospitalization costs of each CVRD manifestations were estimated from the perspective of all payers.

Results
From 2,079,089 type 2 diabetes without cancer or transplantation, 76.5% were free of CVRD at baseline with a mean age of 65 years, 52% of women and 7% with microvascular complications history. The cumulative incidence of a first CVRD manifestation was 15.3% after 5 years of follow-up with a constant linear increase over time for all CVRD manifestations: The most frequent was CKD representing 40.6% of first occurred CVRD manifestation, followed by HF (23.0%), then PAD (13.5%), stroke (13.2%) and MI (9.7%). HF and CKD together reached about one patient out of ten after 5 years and represented 63.6% of first CVRD manifestations. The 5-year global cost of all CVRD hospitalizations was 3.9 billion euros (B€), i.e. 2,450€ per patient of the whole cohort, with an exponential increase over time for each specific CVRD manifestation. The costliest was CKD (2.0 B€), followed by HF (1.2 B€), then PAD (0.7 B€), stroke (0.6 B€) and MI (0.3 B€).

Conclusions/interpretation
While MI, stroke and PAD remain classic major risks of complications for CVRD-free type 2 diabetes, HF and CKD nowadays represent individually a higher risk and cost than each of these classic manifestations, and jointly represents a risk and a cost twice as high as these three classic manifestations all together. This should encourage the development of specific HF and CKD preventive strategies.
Modified Gexia-Zhuyu Tang inhibits gastric cancer progression by restoring gut microbiota and regulating pyroptosis
Authors: Zhao Tingting , Yu Zhijian 
Published: January 2024

Abstract
Background
Gexia-Zhuyu Tang (GZT), a traditional Chinese medicine formula, is used to treat a variety of diseases. However, its roles in gastric cancer (GC) remain unclear.

Objective
The aim of this study was to explore the roles and underlying molecular mechanisms of modified GZT in GC.

Methods
The effects of modified GZT on GC were investigated by constructing mouse xenograft models with MFC cell line. The fecal samples from low-dose, high-dose, and without modified GZT treatment groups were collected for the 16S rRNA gene sequencing and fecal microbiota transplantation (FMT). Histopathological alterations of mice were evaluated using the hematoxylin–eosin (HE). Immunohistochemical (IHC) analysis with Ki67 and GSDMD was performed to measure tissue cell proliferation and pyroptosis, respectively. Proteins associated with pyroptosis, invasion, and metastasis were detected by Western blotting. Enzyme-linked immunosorbent assay (ELISA) was used to assess inflammation-related factors levels.

Results
Modified GZT inhibited GC tumor growth and reduced metastasis and invasion-related proteins expression levels, including CD147, VEGF, and MMP-9. Furthermore, it notably promoted caspase-1-dependent pyroptosis, as evidenced by a dose-dependent increase in TNF-α, IL-1β, IL-18, and LDH levels, along with elevated protein expression of NLRP3, ASC, and caspase-1. Additionally, modified GZT increased species abundance and diversity of the intestinal flora. FMT assay identified that modified GZT inhibited GC tumor progression through regulation of intestinal flora.

Conclusions
Modified GZT treatment may promote pyroptosis by modulating gut microbiota in GC. This study identifies a new potential approach for the GC clinical treatment.
Characterization of a nuclear transport factor 2-like domain-containing protein in Plasmodium berghei
Authors: Niikura Mamoru , Fukutomi Toshiyuki , Mitobe Jiro , Kobayashi Fumie 
Published: January 2024

Abstract
Background
Plasmodium lacks an mRNA export receptor ortholog, such as yeast Mex67. Yeast Mex67 contains a nuclear transport factor 2 (NTF2)-like domain, suggesting that NTF2-like domain-containing proteins might be associated with mRNA export in Plasmodium. In this study, the relationship between mRNA export and an NTF2-like domain-containing protein, PBANKA_1019700, was investigated using the ANKA strain of rodent malaria parasite Plasmodium berghei.

Methods
The deletion mutant Δ1019700 was generated by introducing gene-targeting vectors into the P. berghei ANKA genome, and parasite growth and virulence were examined. To investigate whether PBANKA_1019700 is involved in mRNA export, live-cell fluorescence imaging and immunoprecipitation coupled to mass spectrometry (IP-MS) were performed using transgenic parasites expressing fusion proteins (1019700::mCherry).

Results
Deletion of PBANKA_1019700 affected the sexual phase but not the asexual phase of malaria parasites. Live-cell fluorescence imaging showed that PBANKA_1019700 localizes to the cytoplasm. Moreover, IP-MS analysis of 1019700::mCherry indicated that PBANKA_1019700 interacts with ubiquitin-related proteins but not nuclear proteins.

Conclusions
PBANKA_1019700 is a noncanonical NTF2-like superfamily protein.
MET fusions are targetable genomic variants in the treatment of advanced malignancies
Authors: Sun Dantong , Xing Xiaoming , Wang Yongjie , Hou Helei 
Published: January 2024

AbstractTargeted therapy for malignancies has developed rapidly in recent years, benefiting patients harboring genetic mutations sensitive to relevant tyrosine kinase inhibitors (TKIs). With the development of targeted sequencing techniques, an increasing number of detectable genomic alterations in malignancies, including MET fusions, have been revealed. MET fusions, although rare among malignancies, might be functional driver genes that participate in activating downstream signaling pathways and promoting cell proliferation. Therefore, it is believed that MET fusions could be targetable genomic variants of MET, and inhibition of MET is considered an optionable therapeutic choice for patients harboring MET fusions. According to the summary presented in this review, we recommend MET-TKIs as suitable treatment agents for patients harboring primary MET fusions. For patients harboring acquired MET fusions after the development of resistance to TKIs targeting primary genomic alterations, such as sensitive EGFR mutations, treatment with a MET-TKI alone or in combination with TKIs targeting primary genomic alterations, such as EGFR-TKIs, is hypothesized to be a reasonable option for salvage treatment. In summary, MET fusions, despite their low incidence, should be taken into consideration when developing treatment strategies for cancer patients.
Mutual regulation of PD-L1 immunosuppression between tumor-associated macrophages and tumor cells: a critical role for exosomes
Authors: Wang Banglu , Cheng Daoan , Ma Danyu , Chen Rui , Li Dong , Zhao Weiqing , Fang Cheng , Ji Mei 
Published: January 2024

AbstractTumor cells primarily employ the PD-1/PD-L1 pathway to thwart the anti-tumor capabilities of T lymphocytes, inducing immunosuppression. This occurs through the direct interaction of PD-L1 with PD-1 on T lymphocyte surfaces. Recent research focusing on the tumor microenvironment has illuminated the pivotal role of immune cells, particularly tumor-associated macrophages (TAMs), in facilitating PD-L1-mediated immunosuppression. Exosomes, characterized by their ability to convey information and be engulfed by cells, significantly contribute to promoting TAM involvement in establishing PD-L1-mediated immunosuppression within the tumor microenvironment. Exosomes, characterized by their ability to convey information and be engulfed by cells, significantly contribute to promoting TAM involvement in establishing PD-L1-mediated immunosuppression within the tumor microenvironment. In addition to receiving signals from tumor-derived exosomes that promote PD-L1 expression, TAMs also exert control over PD-L1 expression in tumor cells through the release of exosomes. This paper aims to summarize the mechanisms by which exosomes participate in this process, identify crucial factors that influence these mechanisms, and explore innovative strategies for inhibiting or reversing the tumor-promoting effects of TAMs by targeting exosomes.
New absolute paleomagnetic intensity data from Cenozoic basalts of Northeast China and exploring rock-magnetic parameters for efficient sample preselection on the Tsunakawa–Shaw paleointensity method
Authors: Ahn Hyeon-Seon , Lee Youn Soo , Yamamoto Yuhji 
Published: January 2024

AbstractDespite being essential in determining absolute paleomagnetic field intensity (API) with high fidelity over Earth science research topics, API determination still suffers little quantitative success. This is due to common nonideal magnetic behaviors in experiments using natural rocks caused by physiochemical changes in the magnetic minerals contained. Although linking rock-magnetic parameters to API results may be fundamental, negligible effort has been made using the Tsunakawa–Shaw (TS) API method despite its potentially high experimental success rate in overcoming nonideal magnetic effects. Here, we explore the relationships between rock-magnetic parameters retrieved using relatively rapid and widely pre-conducted measurements and TS API results from late Cenozoic basaltic rocks. We selected rock-magnetic parameters quantified from strong-field high-temperature thermomagnetic curves, magnetic hysteresis loops, and back-field isothermal remanent magnetization demagnetizations. We provide new data pairs of rock-magnetic parameters and TS API results for 41 basaltic rock samples from 8 sites (cooling units) in Northeast China. Then, by compiling them with published data of similar quality, we compiled 133 pairs of rock-magnetic and TS API data at the sample level (38 sites). Using this data compilation, the following topics of interest were identified: Magnetic coercivity (Bc) and remanence coercivity (Bcr) among the hysteresis parameters, and the thermomagnetic parameter ITC|m| (an index of thermal change quantifying an average of the differences in saturation magnetization at a full temperature range of during a single heating–cooling run) allow meaningful and efficient discrimination between data subsets divided by “success” or “failure” in the API results. We propose sample preselection criteria for the TS experiment: a minimal set of Bc ≥ 13 mT (or Bcr ≥ 26 mT) and ITC|m|≤ 0.15. Moreover, extended consideration based on the preselection criteria may allow the screening of potentially biased specimen/sample-level API estimates in the site-averaged determination of such a site with a large within-site API dispersion.
Graphical Abstract
Variation in Hospital Mortality After Complex Cancer Surgery: Patient, Volume, Hospital or Social Determinants?
Authors: Munir Muhammad Musaab , Woldesenbet Selamawit , Endo Yutaka , Dillhoff Mary , Cloyd Jordan , Ejaz Aslam , Pawlik Timothy M. 
Published: January 2024

Abstract
Introduction
We sought to define the individual contributions of patient characteristics (PCs), hospital characteristics (HCs), case volume (CV), and social determinants of health (SDoH) on in-hospital mortality (IHM) after complex cancer surgery.

Methods
The California Department of Health Care Access and Information database identified patients who underwent esophagectomy (ES), pneumonectomy (PN), pancreatectomy (PD), or proctectomy (PR) for a malignant diagnosis between 2010 and 2020. Multi-level multivariable regression was performed to assess the proportion of variance explained by PCs, HCs, CV and SDoH on IHM.

Results
A total of 52,838 patients underwent cancer surgery (ES: n = 2,700, 5.1%; PN: n = 30,822, 58.3%; PD: n = 7530, 14.3%; PR: n = 11,786, 22.3%) across 294 hospitals. The IHM for the overall cohort was 1.7% and varied from 4.4% for ES to 0.8% for PR. On multivariable regression, PCs contributed the most to the variance in IHM (overall: 32.0%; ES: 21.6%; PN: 28.0%; PD: 20.3%; PR: 39.9%). Among the overall cohort, CV contributed 2.4%, HCs contributed 1.3%, and SDoH contributed 1.2% to the variation in IHM. CV was the second highest contributor to IHM among ES (5.3%), PN (5.3%), and PD (5.9%); however, HCs were a more important contributor among patients who underwent PR (8.0%). The unexplained variance in IHM was highest among ES (72.4%), followed by the PD (67.5%) and PN (64.6%) patient groups.

Conclusions
PCs are the greatest underlying contributor to variations in IHM following cancer surgery. These data highlight the need to focus on optimizing patients and exploring unexplained sources of IHM to improve quality of surgical care.
Για την τύχη του έργου του Johannes Leunclavius Juris Graeco-romani στην Ανατολή
Authors: Apostolopoulos Dimitris G. 
Published: January 2024

Sur le sort de l’oeuvre de Johannes Leunclavius Juris Graeco-romani en Orient. Le premier exemplaire de 1612
Le sort d’un livre imprimé rassemblant des textes en langue grecque, édité à Francfort en 1596, a déjà été évoqué dans des recherches scientifiques. L’æuvre de Johannes Leunclavius, Juris graeco-romani, tam canonici quam civilis, en deux volumes, contenant des textes de droit canon byzantin en version gréco-latine, a été utilisé en 1712 par le patriarcat de Constantinople pour une affaire du droit de la famille, comme on le savait déjà, et, presque à la même époque a été invoqué par un prêtre qui vivait dans le Péloponnèse, dans la ville de Mistra, afin de réaliser sa volonté de gravir les échelons de la hiérarchie. Le nouvel élément introduit par la présente étude tient à la redatation de l’époque d’apparition du livre en Orient : au lieu de 1712, il faut la placer en 1612. Un exemplaire de cet ouvrage, qui est conservé aujourd’hui dans la bibliothèque du monastère athonite de la Grande Lavra, provient de la bibliothèque de celui qui fut le patriarche de Constantinople au XVIIe siècle, du 21 juin 1662 au 21 octobre 1665. Ce patriarche, Dionysios III, a voulu léguer une partie de sa bibliothèque au monastère athonite. D’après les notes bibliographiques conservées dans le deuxième volume de l’ouvrage, on sait d’abord que Dionysios a acquis l’imprimé en 1650, avant même de devenir patriarche ; plus important encore, cet exemplaire a été acheté en 1612 en Pologne, à Lublin, par un marchand d’Épire Jean Simotas, afin de l’offrir au « seigneur » originaire de Chio, Michel Kavakos, habitant alors de Constantinople. En raison des relations étroites de Kavakos avec le patriarcat de Constantinople, on peut raisonnablement supposer que l’ouvrage a été connu par la chancellerie patriarcale, car quelques années plus tôt les traces d’un recueil légal similaire, celui qui a été appelé « Le ‘‘Nomimon’’ de la Grande Église » avaient été perdues. C’ est là une hypothèse de travail dont je pense qu’elle mérite d’être étudiée.
Τα κατασχεμένα του Πούπλιου Μαρκίδη Πούλιου
Authors: Athini Stessi 
Published: January 2024

Les livres confisqués de Pouplios Markidis Poulios. Une clé pour le trafic du livre français pendant les années de maturation des Lumières néo-helléniques
L’aventure de l’imprimeur Pouplios Markidis Poulios à Bucarest en 1797 est bien connue : le fond de livres en langue étrangère qu’il avait illégalement importé a été confisqué par le consulat autrichien à la suite des actions entreprises par le souverain de Valachie, Alexandre Ypsilanti. Grâce à la liste des titres de ces livres conservée dans les archives autrichiennes(publiée par Hurmuzaki) et, surtout, grâce à la possibilité que nous avons d’accéder par Internet aux bibliographies, aux catalogues de bibliothèques et aux copies numérisées, il nous a été possible de reconstituer l’identité bibliographique de la quasi-totalité des æuvres confisquées. On constate que les livres français de l’Ancien Régime (traités philosophiques et/ou sur l’athéisme, ouvrages de politique et d’économie, satires anticléricales, chroniques scandaleuses, littérature érotique/pornographique, etc.) en constituent la plus grande partie. Il s’agit de «livres philosophiques» clandestins qui recensent l’inventaire de la mythologie de la décadence, du despotisme, de la corruption des mæurs, de l’hypocrisie sociale et de la transgression religieuse, tout en démasquant la spéculation et les scandales. Grâce à un réseau bien organisé ayant comme point de départ des imprimeries qui s’activaient hors des frontières françaises –la plus connue étant la Société Typographique de Neuchâtel– ils étaient distribués dans toute l’Europe. Une partie des livres confisqués de Poulios pourrait provenir du stock de Thomas Trattner, imprimeur notoire qui vendait des livres français clandestins à Vienne et des réimpressions pirates de ces livres sur le territoire des Habsbourg. Mais il se peut aussi que ces ouvrages soient des contrefaçons provenant de l’imprimerie de Poulios. À en juger par les traductions et les références repérées (Rétif de la Bretonne, Delisle de Sales, Mercier, D. Katartzis) il semble que le «monde souterrain» du livre philosophique français –dont une partie importante avait été interdite par la censure autrichienne– avait réussi à pénétrer les cercles non seulement de la diaspora grecque mais aussi des Principautés Danubiennes et ceci avant la «décennie cruciale des années 1790». L’interdiction de la circulation des livres en 1797 est liée à la conversion idéologique d’Ypsilanti et à son alignement sur la politique anti-française des Habsbourg. Les ouvrages confisqués de Poulios ouvrent un champ de recherche fructueux sur la contribution des livres clandestins français à la maturation des Lumières. Une liste des titres des livres confisqués est jointe en annexe.
Ιδιωτικός και δημόσιος βίος του Γρηγοράκη Σούτσου, Φαναριώτη (1796;-1829)
Authors: Politis Alexis 
Published: January 2024

Grégoire Soutzo, Phanariote
Grégoire Soutzo est né en Constantinople vers 1796. Les premiers renseignements sur sa jeunesse nous sont connus par les divers mémoires du comte de Marcellus, qui était consul de France à l’Empire Ottoman les années avant 1821. Ces renseignements portent sur des détails, souvent inconnus et intéressants, de la vie contemporaine et littéraire.
Fin 1819 ou début 1820, Grégoire Soutzo est appelé à Bucarest par son oncle Alexandre N. Soutzo, prince de Moldavie. Il travaille làcomme son secrétaire, il devient membre de la “Société Amicale” [Philiki Etaireia], il prend part aux mouvements révolutionnaires d’Alexandre Hypsilanti. Il s’échappe à Odessa, et à 1822 il va à Paris, où il fait des études de droit et il s’associe aux circuits philhelléniques.
Au printemps de 1826 il vient en Grèce, et il sert comme juge, et, avec ses collaborateurs il prépare l’organisation juridique du nouvel état. Capodistrias le nomme membre de “Panhellénion” et lui confie des fonctions juridiques, mais leur collaboration est suspendue à cause des comportements amoureux de Soutzo qui ne sont pas acceptés par les mæurs de l’époque. Il meurt pendant l’épidémie de typhus à Nauplie en Octobre 1827.
Ο Αίσωπος στην οθωμανική γραμματεία του 19ου αι.
Authors: Balta Evangelia 
Published: January 2024

Aesop in the Ottoman Literature of the 19th century
The study based on the Karamanlidika version of Aesop’s fables printed by Evangelinos Misailidis in 1854 offers a review of the Ottoman perception of Aesop in the 19th century. The Turkish versions of the fables released in various alphabets (Cyrillic, Arabic), and the Vita of Aesop, are presented and explored. The study also discusses the Turkish manuscript written in Greek characters, located by Ernst Otto Blau in Mariupol, today in southern Ukraine. His discovery proves that Aesop appeared in the handwritten form at least as far back as the 18th century and also indicates that Aesop was introduced to the Ottoman literature by the Turkish-speaking Rums. Unfortunately, the manuscript has not survived, but Blau added excerpts from the life of Aesop and two of his fables in his study published in 1874.
The institutional fate of Uexküll’s umwelt theory at the University of Hamburg
Authors: Kirschner Stefan 
Published: January 2024

Due to Jakob von Uexküll’s umwelt theory, the Institute for Umwelt Research at the University of Hamburg, that was founded in 1928, was a unique institution worldwide for holistic research into animal behaviour and perception. However, Uexküll’s vitalistic-teleological approach and his uncompromising anti- Darwinian stance increasingly isolated him. When the closure of his institute was imminent as part of his statutory retirement in 1935, Uexküll ingratiated himself with the National Socialists in a letter to the Reich Minister for Science, Education, and Culture, which serves as a starting point for the article’s detailed discussion of his relationship to National Socialism.
Since umwelt theory could be used for the training of guide dogs and other animals useful for military purposes, the institute survived. Still, finding a suitable successor to Uexküll proved difficult because hardly anyone among the German zoologists believed Friedrich Brock, Uexküll’s preferred candidate, would live up to Uexküll’s originality. The most important opponent to Brock’s appointment was Berthold Klatt, professor of zoology at the University of Hamburg, who did not expect any significant progress in zoology from Uexküll’s umwelt theory. After Brock’s death in 1958, the sworn circle of supporters of Uexküll’s umwelt theory tried in vain to push through a successor from their ranks. At the instigation of Curt Kosswig, Klatt’s successor in the Chair of Zoology, Franz Sauer succeeded Brock in 1959. However, a polemical article written by Gösta von Uexküll provoked a scandal, in the wake of which Sauer resigned. In 1960 the Institute for Umwelt Research became a department of the Zoological Institute, existing in the lecture timetables until 1966.
Thus, the fate of Uexküll’s research institution depended mainly on external and personal factors or, to speak in Uexküllian terms, on the umwelten of the protagonists and antagonists.