bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Scalable Production of Sodium‐Ion Batteries: Solvent‐Free Layered‐Oxide Cathodes and Aqueous‐Processed Hard Carbon Anodes for Cost‐Effective Full‐Cell Manufacturing
Authors: Kühn Johannes , Schmidt Florian , Seete Pascal , Boenke Tom , Hoffmann Florian S. , Dupuy Arthur , Schumm Benjamin , Abendroth Thomas , Althues Holger , Kaskel Stefan 
Published: January 2025

AbstractAchieving commercial viability for more sustainable sodium‐ion batteries (SIB) necessitates reducing the environmental impact of production, particularly originating from electrode drying and the use of toxic solvents like N‐methyl‐2‐pyrrolidone (NMP). This study presents the dry‐processing of commercial P2‐type Na0.75Ni0.25Fe0.25Mn0.50O2 (NFM) via the DRYtraec® process, aiming to lower the binder content of 1 wt.% polytetrafluoroethylene (PTFE) and eliminating the need for electrode drying and NMP recovery. Assessments of electrode morphology and active material crystallinity were conducted to gauge the effects of mechanical stress during processing. The resulting cathodes, loaded at a commercially relevant 2.3–2.7 mAh cm−2 loading, were successfully paired with aqueous‐processed hard carbon (HC) anodes, demonstrating stable performance in full‐cells. Comparative analysis with entirely wet‐processed electrodes revealed comparable capacity accessibility and comparable long‐term stability. This showed the competitiveness of dry‐processed cathodes. Finally, the integration of NMP‐free, dry‐processed cathodes and aqueous‐processed anodes was scaled to the commercially relevant prototype pouch‐cell. The cell demonstrates stable cycling for 400 cycles with an energy density of 102 Wh kg−1 as well as reduced processing costs and environmental footprint.
Supporting Procedural Fidelity of Behavioral Interventions for Children With Autism via an Artificial Intelligence Platform
Authors: Yagafarova Aliya , Dowling Emily , LaMonica Toni , Hantula Donald A. , Nosek John T. , Jimenez‐Gomez Corina 
Published: January 2025

ABSTRACTAccess to behavior analytic services is limited and often unavailable for many in areas with a dearth of qualified providers. Tools to support behavior‐change agents located in the natural environment of consumers may be a way to provide behavioral interventions. An artificial intelligence (AI) platform that guides the implementation of behavioral interventions may be useful for supporting procedural fidelity. The current studies evaluated whether an AI platform was effective at increasing and maintaining high levels of procedural fidelity in individuals with little to no prior training. Participants were two behavior technicians in training (Exp. 1) and three caregivers (Exp. 2). Introducing guidance provided by the AI platform GAINS improved the procedural fidelity with which behavior technicians and caregivers implemented behavioral interventions with children with autism, except for one caregiver. These results suggest AI platforms may be useful tools for supporting high levels of procedural fidelity by novice users.
Osteochondral Tissue Engineering: Scaffold Materials, Fabrication Techniques and Applications
Authors: Wang Zhenyu , Xu Jie , Zhu Jingjing , Fang Huan , Lei Wanyu , Qu Xinrui , Cheng Yuen Yee , Li Xiangqin , Guan Yanchun , Wang Hongfei , Song Kedong 
Published: January 2025

ABSTRACTOsteochondral damage, caused by trauma, tumors, or degenerative diseases, presents a major challenge due to the limited self‐repair capacity of the tissue. Traditional treatments often result in significant trauma and unpredictable outcomes. Recent advances in bone/cartilage tissue engineering, particularly in scaffold materials and fabrication technologies, offer promising solutions for osteochondral regeneration. This review highlights the selection and design of scaffolds using natural and synthetic materials such as collagen, chitosan (Cs), and polylactic acid (PLA), alongside inorganic components like bioactive glass and nano‐hydroxyapatite (nHAp). Key fabrication techniques—freeze‐drying, electrospinning, and 3D printing—have improved scaffold porosity and mechanical properties. Special focus is placed on the design of multiphasic scaffolds that mimic natural tissue structures, promoting cell adhesion and differentiation and supporting the regeneration of cartilage and subchondral bone. In addition, the current obstacles and future directions for regenerating damaged osteochondral tissues will be discussed.
Sustainability Practices Impacts on Supplier Sustainability Risks and Sustainability Performance: An Empirical Study of Brazilian Companies
Authors: Romano André Luiz , Ferreira Luis Miguel D. F. , Caeiro Sandra Sofia F. S. 
Published: January 2025

ABSTRACTThis study explores the influence of sustainability practices on supplier sustainability risks and sustainability performance in Brazilian companies, offering key insights into how behavioral and technical practices impact these crucial areas. Data were collected from 152 Brazilian companies across various sectors. The theoretical framework was tested using partial least squares structural equation modeling. The research findings highlight that implementing behavioral sustainability practices has a positive effect on reducing supplier sustainability–related risks and improving overall sustainability performance in supply chains. These practices, focused on fostering sustainable behaviors within organizations and among suppliers, play a critical role in mitigating sustainability risks and enhancing long‐term performance. Unexpectedly, the study did not confirm the predicted relationship between technical sustainability practices and improvements in supplier sustainability–related risks and performance. This surprising result challenges traditional assumptions about the effectiveness of technical practices in improving supply chain sustainability performance. By uncovering the distinct impact of behavioral versus technical sustainability practices, the study provides valuable insights for both researchers and practitioners. It emphasizes the importance of promoting behavioral change to achieve meaningful sustainability outcomes. The findings have practical implications for companies aiming to enhance their sustainability strategies and manage sustainability risks more effectively within their supply chains, making this research a significant contribution to sustainable management and supply chain theory.
Pre‐folding purification procedures for inclusion body‐derived non‐tagged cationic recombinant proteins with multiple disulfide bonds for efficient refolding
Authors: Kimura Shuichiro , Yamamoto Wataru , Miyamoto Ai , Imamura Koreyoshi , Futami Junichiro 
Published: January 2025

AbstractThe production of disulfide‐containing recombinant proteins often requires refolding of inclusion bodies before purification. A pre‐refolding purification step is crucial for effective refolding because impurities in the inclusion bodies interfere with refolding and subsequent purification. This study presents a new pre‐refolding procedure using a reversible S‐cationization technique for protein solubilization and purification by reversed‐phase high performance liquid chromatography. This pre‐folding purification step improves refolding yield by effectively removing the refolding inhibitors from contaminates from bacterial inclusion bodies, and reducing proteolytically degraded products. Because this procedure does not require a peptide tag for affinity purification, it is a superior technique to subsequently perform a simplified downstream process wherein the affinity tag needs to be removed. This study reports improved refolding and purification procedure to obtain the highly cationic (pI = 9.25) mouse vascular endothelial cell growth factor (188 amino acids form) that is used as a model protein in our study; this protein shows a homodimeric conformation and possesses multiple disulfides.
Pyridine Derivatives and Furan Derivatives Identified From the Medicinal Mushroom Irpex lacteus SY1002
Authors: Yu Guihong , Shang Zhaomeng , Li Wanting , Peng Jixing , Mo Xuhua , Yang Song , Tan Lingling 
Published: January 2025

ABSTRACTThree new pyridine derivatives, irpelactedines A–C (1–3), and a new furan derivative, irpelactedine D (5), along with two structurally related known compounds, irpexidine A (4) and 5‐carboxy‐2‐furanpropanoic acid (6), were isolated from the medicinal fungus Irpex lacteus SY1002. Their structures were elucidated through nuclear magnetic resonance and mass spectral analyses, combined with density functional theory calculations of electronic circular dichroism data. Evaluation of angiotensin‐converting enzyme (ACE) inhibitory activity revealed that compounds 1 and 3 displayed moderate inhibition, with IC50 values of 31.49 ± 3.41 and 80.96 ± 6.93 µg/mL, respectively. Molecular docking suggested that compound 1 is bound to the active site of ACE, leading to a reduction in its activity. Furthermore, cytotoxicity and antimicrobial activity tests revealed the low toxicity of these compounds. This is the first report on the ACE inhibitory activity of this class of pyridine derivatives, providing valuable insights into exploring the medicinal potential of I. lacteus and offering a structural template for developing new ACE inhibitors. Future efforts will focus on optimizing their structure and conducting in vivo testing to assess their therapeutic potential.
An Alignment‐Agnostic Methodology for the Analysis of Designed Separations Data
Authors: Sorochan Armstrong Michael , Camacho José 
Published: January 2025

ABSTRACTChemical separations data are typically analyzed in the time domain using methods that integrate the discrete elution bands. Integrating the same chemical components across several samples must account for retention time drift over the course of an entire experiment as the physical characteristics of the separation are altered through several cycles of use. Failure to consistently integrate the components within a matrix of samples and variables creates artifacts that have a profound effect on the analysis and interpretation of the data. This work presents an alternative where the raw separations data are analyzed in the frequency domain to account for the offset of the chromatographic peaks as a matrix of complex Fourier coefficients. We present a generalization of the factorization, permutation testing, and visualization steps in ANOVA‐simultaneous component analysis (ASCA) to handle complex matrices and use this method to analyze a synthetic dataset with known significant factors and compare the interpretation of a real dataset via its peak table and frequency domain representations.
Colorimetric Detection of Naphthalene Enabled by Intra‐ to Intermolecular Charge Transfer Interplay Induced by π‐hole⋅⋅⋅π Interactions of a TPA‐Attached Pyrazinacene
Authors: Nakada Kazushi , Richards Gary James , Hori Akiko 
Published: January 2025

AbstractA new Donor‐Acceptor type pyrazinacene derivative (1) featuring strong ICT was synthesized by linking electron‐donating triphenylamine (TPA) and electron‐accepting CN groups via a pyrazinacene core. The compound exhibits a dramatic color change from greenish blue to red‐violet upon selective recognition of naphthalene (3) to form a 1:1 co‐crystal (1•3). This color change is induced by intermolecular CT between pyrazinacene and naphthalene's aromatic moieties, driven by π‐hole⋅⋅⋅π interactions. Crystal structure analysis and DFT calculations confirm that the molecular recognition process is facilitated by the unique π‐hole⋅⋅⋅π interactions, leading to a reversible color switching mechanism. The findings offer new insights into selective molecular recognition and ICT‐CT interplay in nonporous adaptive crystals.
Power Imbalance Analysis and Minimum Imbalance Power Based Power Balance Control for Nonagonal MMC in FFTS‐Based Offshore Wind Farm
Authors: Liu Wenjun , Xu Bicheng , Huang Wenhui , Wang Yaoqiang , Chen Genxu , Chen Yan 
Published: January 2025

ABSTRACTNonagonal modular multilevel converter (MMC) can achieve three‐port direct AC‐AC conversion and has good low frequency performance. Additionally, due to its highly branch‐reused structure, it is advantageous in cost and size for the application in FFTS‐based offshore wind farm. However, the instantaneous power of the branches in nonagonal MMC has an inherent DC component which would result in power imbalance and system instability. The traditional way to suppress the imbalance power is to insert DC neutral point bias voltages and indirectly generating a DC component in circulating current. Together, they can offset the imbalance power. Nonetheless, this would significantly increase the voltage and current stress of converter switching devices and hence weakening its advantages in cost. To address this issue, the generating mechanism of power imbalance is analyzed by comparing nonagonal MMC with other power balanced converters. The formerly neglected phase angle difference of the same frequency ports is also considered and is proved to have a significant influence on the overall imbalance power. Accordingly, a parameter adjustment method is proposed to obtain minimum imbalance power for nonagonal MMC. The effectiveness of the parameter adjustment method is verified by RTlab results, and the overall imbalance power can be reduced by as great as 99.35%.
Peganum harmala Polysaccharide Mitigates LPS‐Induced Inflammatory Response in Macrophages by Activating Autophagy Pathway
Authors: Rejiepu Manzeremu , Shen Jun , Liang Junqing , Maitikabili Alaili , Yang Jian , Zhang Ling , Mi Na 
Published: January 2025

ABSTRACTPeganum harmala, a member of the Zygophyllaceae family, is known for its diverse biological activities, including anti‐inflammatory properties. The mechanisms through which P. harmala polysaccharide (LTP) induces autophagy, however, remain largely unexplored. This study aims to elucidate the role of LTP in autophagy induction and its efficacy in mitigating inflammation within macrophages. Autophagosome formation was evaluated using GFP‐LC3 vectors, and LC3‐II levels induced by LTP were analyzed through laser scanning confocal microscopy. Western blotting assessed the expression of autophagy‐related proteins and the phosphorylation state of p70S6K in NRK cells, treated both with and without LTP, alongside autophagy inducers and inhibitors. Additionally, RAW264.7 cells were treated with 1 μg/mL lipopolysaccharides (LPS), followed by Western blotting and ELISA assays to quantify inflammatory markers. The study's outcomes demonstrate that LTP facilitates an increase in autophagic activity, as evidenced by the enhanced expression of LC3‐II and reduced levels of p62 in both NRK and RAW264.7 macrophages. This effect is mediated through the activation of the AMPK‐mTOR signaling pathway, without inhibiting the autophagosome–lysosome fusion process. In vitro experiments with RAW264.7 cells treated with 1 μg/mL LPS showed that LTP markedly decreased the levels of TNF‐α and IL‐6. Our findings indicate that LTP effectively reduces inflammation in LPS‐stimulated macrophages by promoting autophagy via an mTOR‐dependent mechanism.
Spatial–Temporal Variation of Grain Magnesium, Calcium and Their Response to Phosphorus Nutrition in Sweet Corn
Authors: Su Da , Jin Zhiya , Ou Jie , Muneer Muhammad Atif , Jiang Yunfei , Ye Delian , Wu Liangquan , Yan Xiaojun 
Published: January 2025

ABSTRACTSweet corn (Zea mays L. saccharata) is gaining global popularity as a staple crop and a vegetable due to its high nutritional value. However, information on grain magnesium (Mg) and calcium (Ca) status and their response to phosphorus (P) fertilization in sweet corn is still insufficient. In the current study, we combined the genotype evaluation and P gradient experiments to investigate how P supply influences the spatio‐temporal variation of grain mineral nutrition (Mg and Ca) and their bioavailabilities in sweet corn. Increasing P decreased grain Ca by 16.7%, from 0.18 to 0.15 g kg−1, but increased phytic acid phosphorus (PAP) concentration by 7.4%. Optimal P levels increased grain Mg concentration by 14.7%, from 1.36 to a peak of 1.56 g kg−1; however, excessive P reduced it by 3.8% to 1.50 g kg−1. Spatially, optimal P increased the grain Mg concentration across all cob positions and in the germ, with the largest variation observed at the upside position (Coefficient of variation (cv) = 11.88%). Conversely, high P decreased Mg concentration in middle‐cob grains and the germ. High P also reduced Ca in the upper/middle‐cob grain and in both germ and endosperm. P consistently increased grain PAP but reduced Mg and Ca bioavailability across all growth stages, all grain fractions, and the middle/bottom cob positions. Notably, PAP showed the largest variation at the late growth stage in bottom cob grains (CV = 8.75%). Mg and Ca bioavailabilities exhibited significant variations, primarily in upper grains during the early filling stage, with CVs reaching 14.5% and 43.23%, respectively. Temporally, early grain growth stage was more sensitive to P‐induced changes in Mg, Ca and their bioavailabilities, while later growth stage was more responsive to grain PAP alterations. These findings suggest that reducing P input can be advantageous for achieving high Mg and Ca biofortified sweet corn grain.
Association between body mass index, obesity, and vulvar cancer recurrence
Authors: Tzur Yossi , Magri Angela , Meyer Raanan , Brodeur Melica Nourmoussavi , Salvador Shannon , Lau Susie , Gotlieb Walter , Levin Gabriel 
Published: January 2025

AbstractObjectiveThe objective of this paper is to study the association between obesity and tumor recurrence in patients with vulvar cancer.MethodsThis is a retrospective study including vulvar cancer patients from 2003 to 2022. Our primary outcome was progression‐free survival (PFS) stratified by status of obesity, defined as body mass index (BMI) >30.0 kg/m2.ResultsOverall, 48 patients were included in the study, with 32 (66.7%) diagnosed at early stages (I–II). The median BMI was 28.0 kg/m2 [interquartile range 24.9–32.3 kg/m2]. There were 13 obese patients (27%), and the median follow‐up time was 55 months [interquartile range 14–102]. Most patients (80%) were HPV‐independent of human papilloma virus. Surgical intervention was the primary treatment modality for 88% (n = 42) of the cohort, and 26 patients (54%) received adjuvant chemoradiation. Disease recurrence was identified in 28 patients (58%). The median PFS was 68 months, and the median overall survival was 109 months. There was no difference in the median PFS between obese patients and non‐obese patients (P = 0.370). In a Cox regression analysis, after adjusting for patient age, margin‐free distance, and stage of disease, BMI was not associated with PFS hazard ratio 1.06 (0.99–1.12).ConclusionObesity is not associated with PFS in patients with vulvar cancer, and BMI might not be considered a risk factor for recurrence.
MicroRNA‐microbiota interactions: Emerging strategies for modulating intestinal homeostasis and enhancing host health
Authors: He Tianle , Ma Jiaying , Liu Shuai , Ma Boyan , You Jingtao , Wang Jingjun , Li Mengmeng , Wang Wei , Wang Ya Jing , Li Shengli , Cao Zhijun 
Published: January 2025

AbstractLong‐term artificial selection and environmental shifts have driven adaptive changes in both the host genome and the intestinal microbiota. The complex symbiotic relationship between these two has become essential for maintaining intestinal homeostasis and overall health. Concurrently, advancements in sequencing technology and the functional annotation of noncoding RNAs, particularly microRNAs (miRNAs), have facilitated the exploration of mechanisms regulating intestinal homeostasis. Herein, we systematically update the role of miRNA–microbiota interactions in regulating the intestinal barrier, intestinal immunity, changes in intestinal microbiota dynamics, and maintenance of intestinal homeostasis, and we further critically discuss the role of miRNA–microbiota interactions in the maintenance of host intestinal health, metabolic regularity, brain function, and neurodegenerative disease‐related disorders. Finally, we highlight the prospects and therapeutic strategies regarding miRNA–microbiota interactions in humans and animals in the context of intestinal microbiota and gene function studies. This study provides a comprehensive overview of miRNA–microbiota interactions and their influence on intestinal homeostasis and host health and offers novel therapeutic strategies for future personalized prevention and treatment of intestinal diseases.
Clinical progress note: Diagnostic approach to dizziness and vertigo
Authors: Kotwal Susrutha , Gold Daniel , Edlow Jonathan A. 
Published: January 2025

AbstractDizziness is a common clinical presentation that incurs huge financial costs. It is frequently misdiagnosed due to a wide differential involving both benign (inner ear disease) and serious (stroke) disorders. Traditional frameworks that emphasize symptom quality (dizziness/lightheadedness/vertigo) lack diagnostic utility. This Clinical Progress Note reviews the literature on acute dizziness evaluation in adult patients and presents an evidence‐based framework for hospitalists to diagnose the majority of undifferentiated dizzy patients at the bedside. Future research should assess the validity of this approach with hospitalists' ability to accurately diagnose dizzy patients, and its impact on patient care and healthcare outcomes.
Combined use of cleft and truncated triangle signs helps improve the preoperative MRI diagnosis of lateral meniscus posterior root tears in patients with ACL injuries
Authors: Yoshihara Aritoshi , Mouton Caroline , Siboni Renaud , Nakamura Tomomasa , Sekiya Ichiro , Koga Hideyuki , Seil Romain , Nakagawa Yusuke 
Published: January 2025

AbstractPurposeThis study aimed to investigate whether combining the analysis of different magnetic resonance imaging (MRI) signs enhances the diagnostic accuracy of lateral meniscus posterior root tears (LMPRTs) in patients with anterior cruciate ligament (ACL) injuries. We hypothesised that analysing the cleft, ghost and truncated triangle signs and lateral meniscus extrusion (LME) measurement together would improve the preoperative MRI‐based diagnosis of LMPRTs.MethodsThis retrospective study used prospectively collected registry data from two academic centres, including patients undergoing primary or revision ACL reconstruction (ACLR) and LMPRT repair. The control group included age‐ and sex‐matched (1:1) patients undergoing ACLR without any lateral meniscus tears. LME (mm) and the presence of cleft, ghost and/or truncated triangle signs were evaluated using preoperative MRI.ResultsIn total, 252 patients (126 per group) were included. Individually, the cleft and truncated triangle signs achieved the highest sensitivity (60% and 62%, respectively) and accuracy (>89%). The presence of either sign increased sensitivity to 79% and enabled the correct classification of 93% of ACL injuries as having or not having an LMPRT, with high specificity (95%) and good positive predictive value (74%). This combination was considered the most efficient in reducing false positives and false negatives. The LME (cutoff value: 2.2 mm) and ghost sign had lower sensitivities (50% and 14%, respectively) and accuracies (83% and 87%) and were not part of the optimal combination.ConclusionThe cleft and/or truncated triangle signs on preoperative MRI reliably detected 79% of LMPRTs in this cohort, with high specificity (95%) and good positive predictive value (74%). This combination provides an effective method for achieving reasonable sensitivity while minimising false positives, aiding surgeons in preoperative diagnosis and planning for LMPRT repair.Level of EvidenceLevel III.