bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenteric Ischemia
Authors: Audu Christopher O. , Schechtman David W. , Davis Frank M. 
Published: December 2023

AbstractMesenteric ischemia occurs when perfusion of the visceral organs fails to meet normal metabolic requirements and subsequently results in abdominal symptoms such as diffuse postprandial pain, peritonitis, food fear, and weight loss. While generally divided into acute and chronic manifestations, mesenteric ischemia is commonly misdiagnosed at initial presentation due to the significant overlap with symptoms of other abdominal pathologies. Prompt recognition and diagnosis, mesenteric revascularization, and critical care management remain the mainstay of treatment in these patients for optimal outcomes. This review will highlight acute versus chronic mesenteric ischemia, their etiology, diagnostic criteria, treatment options, and will emphasize the joint role of the gastrointestinal and vascular surgeon in the timely management of this condition to prevent devastating outcomes.
Obesity and Miscarriage
Authors: McLean Samantha , Boots Christina E. 
Published: December 2023

AbstractObesity affects nearly 40% of reproductive-aged women and has serious implications for women's overall and reproductive health. Women with an elevated body mass index (BMI) have higher rates of anovulation and irregular menses, lower success with fertility treatment, and significantly higher rates of pregnancy complications, such as hypertension/preeclampsia, gestational diabetes, and preterm delivery. Many studies have also shown an association between obesity and early pregnancy loss. However, the causal association between BMI and miscarriage has not been elucidated, likely due to the multifactorial effects that BMI may have on early pregnancy development. In addition, BMI as an isolated variable fails to capture other relevant confounding health risk factors, such as nutrition, physical activity, and insulin resistance. In this review, we will summarize the current literature demonstrating the association between BMI and miscarriage, highlight the research that attempts to explain the association, and finally provide data on therapeutic interventions to improve reproductive outcomes in women suffering from obesity and early pregnancy loss.
International market concentration of fresh blueberries in the period 2001—2020
Authors: Macha Huamán Roberto , Navarro Soto Fabiola Cruz , Ramírez Ríos Alejandro , Alfaro Paredes Emigdio Antonio 
Published: December 2023

AbstractThere were no studies about the structure of the international fresh blueberry market in developing countries for contributing to the development of strategies and policies for the production, imports, and exports of fresh blueberries in the involved countries. The purpose of the study was to evaluate the structure of the international fresh blueberry market in the period 2001–2020. The research design was non-experimental, and longitudinal, with trends on per capita consumption, the market concentration index, and a multiple linear regression model. It was concluded that per capita consumption is led by Canada and the USA and that the concentration indices of the four main countries [CR(4)] of production, imports, and exports went from very high concentration levels to high concentration levels. The eight main countries [CR(8)] of production and exports were at a very high level and imports went from a very high level to a high level; in addition, the Herfindal–Hirschman-Index (HHI) of production was at a highly concentrated level: (a) highly concentrated level in imports in the period 2001–2018, (b) moderately concentrated from 2019 in imports, (c) highly concentrated in exports in the period 2001–2009, (d) moderately concentrated in exports in the period 2010–2018, and (e) not concentrated in exports as of 2019; in addition, the multiple linear regression model showed that per capita consumption, market share, price, and production contribute with 94.3% of the explanation of the variability of fresh blueberry exports. Finally, it was recommended to study the blueberry consumption habits and access restrictions to other international markets for increasing blueberry exports.
Meta-thematic analysis of quality in early childhood education and care
Authors: Sağlam Mehmet , Çelik Osman Tayyar , Tunç Yunus , Kahraman Ümit , Açar Davut , Candemir Burcu 
Published: December 2023

AbstractQuality in early childhood education and care (ECEC) has drawn the attention of researchers and practitioners due to its correlation with positive individual, societal, and economic results. In ECEC, however, there is no consensus on quality metrics. This meta-thematic study seeks to provide a framework for quality indicators in ECEC and to identify the contextual factors that influence the perception of quality. The study’s data source comprises 14 published papers conducted in 11 countries using qualitative or mixed methods on quality in ECEC. As a consequence of the analysis, 16 early childhood education and care quality indicators were identified. As a result of the second-level studies, the underlying or associated syntheses in the ECEC quality indicators were uncovered. These include child-centeredness, teacher qualifications, culture and atmosphere of the ECEC center, holistic development, and leadership. In addition, it was concluded that cultural values and beliefs, the centralization degree of the education system, and the expectations of stakeholders are contextual elements that influence the quality and perceptions of quality in ECEC.
The representation of migration in parliamentary settings: critical cross-linguistics corpus-assisted discourse analyses
Authors: Calzada Pérez María 
Published: December 2023

AbstractThis study examines migration representation in three parliamentary chambers: the Spanish Chamber, the European Parliament, and the British House of Commons. The time span of its analysis coincides with the eighth Legislature of Spain (2004–2008). The reasons for this decision are straightforward. If parliaments portray or construct ideological debates in democratic societies, it seems logical to turn our attention to them as a means of assessing the nature and quality of comparable but different multicultural environments in which migration is a major defining feature. Furthermore, this time span allows for an examination of such societies at different ideological phases, for example, Spain’s conceptualisation of migration in the initial stages of parliamentary representation. The study expands the method of corpus-assisted analysis through a critical theoretical framework proposed by the socio-political scientist Zapata-Barrero. Data were obtained from the European Comparable and Parallel Corpus Archive of Parliamentary Speeches. Well-established tools in corpus linguistics, such as frequency and collocation, were employed, leading to an examination of Zapata-Barrero’s reactive and proactive discourses. The quantitative methods used were especially in-depth, undertaking an exhaustive descriptive and statistical treatment and aiming to strengthen the validity of subsequent qualitative analyses. Consequently, a virtuous circle was achieved: the corpus linguistic procedures reached higher levels of theoretical abstraction, while Zapata-Barrero’s framework gained robustness and more potential for generalisation. The study’s originality, thus, lies in the mutual synergies activated by this theoretical and methodological combination.
Research on Pulsar Time Steered Atomic Time Algorithm Based on DPLL
Authors: Zheng Ze-Hao , Liu Yang , Shen Dan , Feng Fan , Liu Jiu-Long , Ma Yue-Xin , Zhu Xiang-Wei 
Published: December 2023

Abstract
In today’s society, there is a wide demand for high-precision and high-stability time service in the fields of electric power, communication, transportation and finance. At present, the time standard in various countries is mainly based on atomic clocks, but the frequency drift of atomic clocks will affect the long-term stability performance. Compared with atomic clocks, millisecond pulsars have better long-term stability and can complement with the excellent short-term stability of atomic clocks. In order to improve the long-term stability of the atomic timescale, and then improve the timing accuracy, this paper proposes an algorithm for steering the atomic clock ensemble (ACE) by ensemble pulsar time (EPT) based on digital phase locked loop (DPLL). First, the ACE and EPT are generated by the ALGOS algorithm, then the ACE is steered by EPT based on DPLL to calibrate the long-term frequency drift of the atomic clock, so that the generated steered atomic time follows both the short-term stability characteristics of ACE and the long-term stability characteristics of EPT, and finally, the steered atomic time is used to calibrate the local cesium clock. The experimental results show that the long-term stability of atomic time after steering is improved by 2 orders of magnitude compared with that before steering, and the daily drift of a local cesium clock after calibration is less than 9.47 ns in 3 yr, 3 orders of magnitude higher than that before calibration on accuracy.
GAABind: a geometry-aware attention-based network for accurate protein–ligand binding pose and binding affinity prediction
Authors: Tan Huishuang , Wang Zhixin , Hu Guang 
Published: December 2023

Abstract
Protein–ligand interactions are increasingly profiled at high-throughput, playing a vital role in lead compound discovery and drug optimization. Accurate prediction of binding pose and binding affinity constitutes a pivotal challenge in advancing our computational understanding of protein–ligand interactions. However, inherent limitations still exist, including high computational cost for conformational search sampling in traditional molecular docking tools, and the unsatisfactory molecular representation learning and intermolecular interaction modeling in deep learning-based methods. Here we propose a geometry-aware attention-based deep learning model, GAABind, which effectively predicts the pocket–ligand binding pose and binding affinity within a multi-task learning framework. Specifically, GAABind comprehensively captures the geometric and topological properties of both binding pockets and ligands, and employs expressive molecular representation learning to model intramolecular interactions. Moreover, GAABind proficiently learns the intermolecular many-body interactions and simulates the dynamic conformational adaptations of the ligand during its interaction with the protein through meticulously designed networks. We trained GAABind on the PDBbindv2020 and evaluated it on the CASF2016 dataset; the results indicate that GAABind achieves state-of-the-art performance in binding pose prediction and shows comparable binding affinity prediction performance. Notably, GAABind achieves a success rate of 82.8% in binding pose prediction, and the Pearson correlation between predicted and experimental binding affinities reaches up to 0.803. Additionally, we assessed GAABind’s performance on the severe acute respiratory syndrome coronavirus 2 main protease cross-docking dataset. In this evaluation, GAABind demonstrates a notable success rate of 76.5% in binding pose prediction and achieves the highest Pearson correlation coefficient in binding affinity prediction compared with all baseline methods.
Epilepsy in childhood and school performance: a nation-wide cohort study
Authors: Dreier Julie W , Trabjerg Betina B , Plana-Ripoll Oleguer , Skipper Niels , Agerbo Esben , Cotsapas Chris , Berg Anne T , Christensen Jakob 
Published: December 2023

Abstract
Childhood epilepsy has been linked to poor academic performance, but large-scale studies are lacking. In this nation-wide study of school-aged children, we examined the association between childhood epilepsy and school performance in standardized tests according to phenotypic and treatment-related characteristics.
We performed a matched register-based cohort study of children born in Denmark (1997–2009) who participated in the Danish National School Test Programme between 2010 and 2019. We used population and health registers to identify children with epilepsy and a randomly sampled sex- and age-matched reference cohort without epilepsy (ratio 1:10). Norm-based test scores from language and mathematics reflecting performance as a percentile of the nation-wide distribution of scores (scale 1–100) were used to assess academic performance. Adjusted differences in mean standardized scores between children with and without epilepsy were estimated using linear regression models.
Among 582 840 children participating in the School Test Programme, we identified 4659 (0.8%) children with epilepsy (52.8% males) and 46 590 matched reference children. Median age at epilepsy onset was 7.5 years (interquartile range: 4.0–10.6). Childhood epilepsy was associated with poorer school performance overall (mean score = 48.2 versus references = 56.7; adjusted difference = −6.7, 95% CI: −7.4 to −6.0), and worse performance was found in all epilepsy subgroups, including in 3534 children with uncomplicated epilepsy (i.e. no other pre-existing neurologic or intellectual disabilities and no identified possible cause for epilepsy; adjusted difference = −6.0, 95% CI: −6.8 to −5.2). No major variation by sex, age or subject was observed, but larger score differences were seen in children using antiseizure medication at time of testing (e.g. valproate monotherapy, adjusted difference = −9.3, 95% CI: −11.5 to −7.0 and lamotrigine monotherapy, adjusted difference = −13.1, 95% CI: −15.0 to −11.3) and in children with psychiatric comorbidity, especially epilepsy with comorbid intellectual disability (adjusted difference = −27.0, 95% CI: −30.0 to −23.9) and epilepsy with comorbid attention deficit/hyperactivity disorder (adjusted difference = −15.7, 95% CI: −19.0 to −12.4). Children with epilepsy scored significantly lower than their unaffected siblings (adjusted difference = −6.2, 95% CI: −7.1 to −5.4).
In conclusion, childhood epilepsy was associated with impaired academic performance throughout schooling, which suggest that there is a widespread need for educational support of children with epilepsy, even when the child has no other comorbidities and when the epilepsy appears well-managed.
Abnormalities of structural covariance of insular subregions in drug-naïve OCD patients
Authors: Zhang Xuedi , Xie Minyao , Li Wangyue , Xu Zhihan , Wang Zhongqi , Jiang Wenjing , Wu Yu , Liu Na 
Published: December 2023

Abstract
The insula plays a significant role in the neural mechanisms of obsessive-compulsive disorder. Previous studies have identified functional and structural abnormalities in insula in obsessive-compulsive disorder patients. The predictive coding model in the context of interoception can explain the psychological and neuropathological manifestations observed in obsessive-compulsive disorder. The model is based on the degree of laminar differentiation of cerebral cortex. The interindividual differences in a local measure of brain structure often covary with interindividual differences in other brain regions. We investigated the anatomical network involving the insula in a drug-naïve obsessive-compulsive disorder sample. We recruited 58 obsessive-compulsive disorder patients and 84 matched health controls. The cortical thickness covariance maps between groups were compared at each vertex. We also evaluated the modulation of Yale–Brown Obsessive-Compulsive Scale scores and obsessive-compulsive disorder duration on thickness covariance. Our findings indicated that the thickness covariance seeded from granular and dysgranular insula are different compared with controls. The duration and severity of obsessive-compulsive disorder can modulate the thickness covariance of granular and dysgranular insula with posterior cingulate cortex and rostral anterior cingulate cortex. Our results revealed aberrant insular structural characteristics and cortical thickness covariance in obsessive-compulsive disorder patients, contributing to a better understanding of the involvement of insula in the pathological mechanisms underlying obsessive-compulsive disorder.
Adaptive adjustment after conflict with group opinion: evidence from neural electrophysiology
Authors: Mao Rui , Long Changquan 
Published: December 2023

Abstract
Individuals inherently seek social consensus when making decisions or judgments. Previous studies have consistently indicated that dissenting group opinions are perceived as social conflict that demands attitude adjustment. However, the neurocognitive processes of attitude adjustment are unclear. In this electrophysiological study, participants were recruited to perform a face attractiveness judgment task. After forming their own judgment of a face, participants were informed of a purported group judgment (either consistent or inconsistent with their judgment), and then, critically, the same face was presented again. The neural responses to the second presented faces were measured. The second presented faces evoked a larger late positive potential after conflict with group opinions than those that did not conflict, suggesting that more motivated attention was allocated to stimulus. Moreover, faces elicited greater midfrontal theta (4–7 Hz) power after conflict with group opinions than after consistency with group opinions, suggesting that cognitive control was initiated to support attitude adjustment. Furthermore, the mixed-effects model revealed that single-trial theta power predicted behavioral change in the Conflict condition, but not in the No-Conflict condition. These findings provide novel insights into the neurocognitive processes underlying attitude adjustment, which is crucial to behavioral change during conformity.
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
Authors: Aakre Kristin M , Apple Fred S , Mills Nicholas L , Meex Steven J R , Collinson Paul O ,   the International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB), Aakre Kristin M , Apple Fred S , Collinson Paul O , Hammarsten Ola , Jaffe Allan S , Meex Steven J R , Mills Nicholas L , Omland Torbjørn , Sandoval Yader , Cullen Louise 
Published: December 2023

Abstract

Background
Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but require reporting cardiac troponin concentrations at low concentrations that are sometimes below the limit of quantification. Whether analytical imprecision at these concentrations contributes to misclassification of patients is debated.

Content
The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers (IFCC C-CB) provides evidence-based educational statements on analytical and clinical aspects of cardiac biomarkers. This mini-review discusses how the reporting of low concentrations of cardiac troponins impacts on whether or not assays are classified as high-sensitivity and how analytical performance at low concentrations influences the utility of troponins in accelerated diagnostic pathways. Practical suggestions are made for laboratories regarding analytical quality assessment of cardiac troponin results at low cutoffs, with a particular focus on accelerated diagnostic pathways. The review also discusses how future use of cardiac troponins for long-term prediction or management of cardiovascular disease may require improvements in analytical quality.

Summary
Clinical guidelines recommend using cardiac troponin concentrations as low as the limit of detection of the assay to guide patient care. Laboratories, manufacturers, researchers, and external quality assessment providers should extend analytical performance monitoring of cardiac troponin assays to include the concentration ranges applicable in these pathways.
Resilience and phenotypic plasticity of Arctic char (Salvelinus alpinus) facing cyclic hypoxia: insights into growth, energy stores and hepatic metabolism
Authors: Ducros Loïck , Touaibia Mohamed , Pichaud Nicolas , Lamarre Simon G 
Published: December 2023

Abstract
Arctic char (Salvelinus alpinus) is facing the decline of its southernmost populations due to several factors including rising temperatures and eutrophication. These conditions are also conducive to episodes of cyclic hypoxia, another possible threat to this species. In fact, lack of oxygen and reoxygenation can both have serious consequences on fish as a result of altered ATP balance and an elevated risk of oxidative burst. Thus, fish must adjust their phenotype to survive and equilibrate their energetic budget. However, their energy allocation strategy could imply a reduction in growth which could be deleterious for their fitness. Although the impact of cyclic hypoxia is a major issue for ecosystems and fisheries worldwide, our knowledge on how salmonid deal with high oxygen fluctuations remains limited. Our objective was to characterize the effects of cyclic hypoxia on growth and metabolism in Arctic char. We monitored growth parameters (specific growth rate, condition factor), hepatosomatic and visceral indexes, relative heart mass and hematocrit of Arctic char exposed to 30 days of cyclic hypoxia. We also measured the hepatic protein synthesis rate, hepatic triglycerides as well as muscle glucose, glycogen and lactate and quantified hepatic metabolites during this treatment. The first days of cyclic hypoxia slightly reduce growth performance with a downward trend in specific growth rate in mass and condition factor variation compared to the control group. This acute exposure also induced a profound metabolome reorganization in the liver with an alteration of amino acid, carbohydrate and lipid metabolisms. However, fish rebalanced their metabolic activities and successfully maintained their growth and energetic reserves after 1 month of cyclic hypoxia. These results demonstrate the impressive ability of Arctic char to cope with its changing environment but also highlight a certain vulnerability of this species during the first days of a cyclic hypoxia event.