bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying new safety risk of human serum albumin: a retrospective study of real-world data
Authors: Lu Hui , Zhang Yuwei , Liu Pengcheng 
Published: January 2024

Objective: To mine and analyze the adverse reaction signals of human serum albumin (HSA) using the FDA adverse event reporting system (FAERS) database for the safe clinical use of this drug.Methods: Data cleaning and analysis of adverse event reports in the FAERS database for a total of 76 quarters from Q1 2004 to Q4 2022 were performed using the reporting odds ratio (ROR), Medicines and Healthcare Products Regulatory Agency (MHRA), and Bayesian confidence propagation neural network (BCPNN). Gender-differentiated signal detection was used to investigate the gender differences in the occurrence of HSA adverse events.Results: Through a combination of three methods, a total of 535 adverse event reports were identified. These reports involved 1,885 cases of adverse reactions, with respiratory, thoracic, and mediastinal disorders, as well as general disorders and administration site conditions, as the most common. One noteworthy new signal was the occurrence of transfusion-related acute lung injury. Additionally, gender-differentiated signals were present, with females experiencing paraesthesia, hypertension, pulmonary oedema, loss of consciousness, and vomiting.Conclusion: This study has revealed that HSA poses a risk of causing transfusion-related acute lung injury. It has also been observed that adverse reactions, including paraesthesia, hypertension, pulmonary oedema, loss of consciousness, and vomiting, are more prevalent in females. These findings should be taken into account when using HSA in a clinical setting.
Hepatic transcriptome analyses of juvenile white bass (Morone chrysops) when fed diets where fish meal is partially or totally replaced by alternative protein sources
Authors: Fuller S. Adam , Abernathy Jason W. , Sankappa Nithin Muliya , Beck Benjamin H. , Rawles Steven D. , Green Bartholomew W. , Rosentrater Kurt A. , McEntire Matthew E. , Huskey George , Webster Carl D. 
Published: January 2024

White bass (Morone chrysops) are a popular sportfish throughout the southern United States, and one parent of the commercially-successful hybrid striped bass (M. chrysops ♂ x M. saxatilis ♀). Currently, white bass are cultured using diets formulated for other carnivorous fish, such as largemouth bass (Micropterus salmoides) or hybrid striped bass and contain a significant percentage of marine fish meal. Since there are no studies regarding the utilization of alternative proteins in this species, we evaluated the global gene expression of white bass fed diets in which fish meal was partially or totally replaced by various combinations of soybean meal, poultry by-product meal, canola meal, soy protein concentrate, wheat gluten, or a commercial protein blend (Pro-Cision™). Six isonitrogenous (40% protein), isolipidic (11%), and isocaloric (17.1 kJ/g) diets were formulated to meet the known nutrient and energy requirements of largemouth bass and hybrid striped bass using nutrient availability data for most of the dietary ingredients. One of the test diets consisted exclusively of plant protein sources. Juvenile white bass (40.2 g initial weight) were stocked into a flow-through aquaculture system (three tanks/diet; 10 fish/tank) and fed the test diets twice daily to satiation for 60 days. RNA sequencing and bioinformatic analyses revealed significant differentially expressed genes between all test diets when compared to fish meal control. A total of 1,260 differentially expressed genes were identified, with major ontology relating to cell cycle and metabolic processes as well as immune gene functions. This data will be useful as a resource for future refinements to moronid diet formulation, as marine fish meal becomes limiting and plant ingredients are increasingly added as a reliable protein source.
Prosocial and externalizing behaviors in children raised by different-and same-gender parent families: new directions in parenting research
Authors: Baiocco Roberto , Favini Ainzara , Pistella Jessica , Carone Nicola , Speranza Anna Maria , Lingiardi Vittorio 
Published: January 2024

IntroductionLimited research focused on the association between parenting practices and children’s prosocial and externalizing behaviors comparing same- and different-gender parent families. The present study considered 76 Italian families (73% same-gender and 27% different-gender parent families) with 8-year-old (SD = 2.17; 49% assigned female at birth) children born through assisted reproductive techniques, to explore parenting practices and children’s prosocial and externalizing behaviors.MethodWe ran a Multiple-group-by-couple Structural Equation Model in which we estimated the predictive role of parenting on children’s behaviors, controlling for age, gender, and family socioeconomic status using the Maximum Likelihood estimation.ResultsResults showed that both same- and different-gender parent families reported high levels of parental warmth and very low levels of hostility and rejection; regarding children’s behaviors, both same- and different-gender parent families reported high levels of prosociality and low levels of externalizing behaviors. In addition, same-gender parents reported significantly higher levels of children’s prosociality and parental warmth than different-gender parents. Regarding associations between parenting practices and behaviors, we found a positive association between positive parenting practices and increasing children’s prosocial behaviors and decreasing children’s externalizing behaviors, in both same- and different-gender families, controlling for family background characteristics.ConclusionThe present study encourages future research to investigate how specific parenting practices can influence behavioral adjustment in children, focusing on same-gender parent families.
Disaster-related deaths with alcohol-related diseases after the Fukushima Daiichi nuclear power plant accident: case series
Authors: Kitazawa Kemmei , Sawano Toyoaki , Uchi Yuna , Kawashima Moe , Yoshimura Hiroki , Murakami Michio , Nonaka Saori , Saito Hiroaki , Sakakibara Mamoru , Yagiuchi Kazuko , Otsuki Mako , Ozaki Akihiko , Yamamoto Chika , Zhao Tianchen , Uchiyama Taiga , Oikawa Tomoyoshi , Niwa Shinichi , Tsubokura Masaharu 
Published: January 2024

IntroductionThe health of patients with mental disorders, such as alcohol-related diseases, often deteriorates after disasters. However, the causes of death among those with alcohol-related diseases during and after radiation disasters remain unclear.MethodsTo minimize and prevent alcohol-related deaths in future radiation disasters, we analyzed and summarized six cases of alcohol-related deaths in Minamisoma City, a municipality near the Fukushima Daiichi nuclear power plant.ResultsPatients were generally treated for alcohol-related diseases. In one case, the patient was forced to evacuate because of hospital closure, and his condition worsened as he was repeatedly admitted and discharged from the hospital. In another case, the patient’s depression worsened after he returned home because of increased medication and drinking for insomnia and loss of appetite.DiscussionThe overall findings revealed that, in many cases, evacuation caused diseases to deteriorate in the chronic phase, which eventually resulted in death sometime after the disaster. To mitigate loss of life, alcohol-related diseases must be addressed during the chronic phases of future large-scale disasters, including nuclear disasters.
Sex differences in patients with COVID-19 after bariatric surgery: a multicenter cross-sectional study
Authors: Wang Senlin , Jang Qiubai , Wang Han , Yang Yunning , Ruan Min , Yu Juan , Li Xiuying , Luo Dan 
Published: January 2024

ObjectivesThis multicenter, cross-sectional study aimed to investigate whether sex differences persist among patients who have undergone bariatric surgery and tested positive for the coronavirus disease (COVID-19).MethodsWe conducted a multicenter cross-sectional study via an online electronic questionnaire to collect data. Categorical data were presented as absolute and relative frequencies. Data for continuous variables were expressed as mean and standard deviation (SD) or median [interquartile range (IQR)]. We employed ordered logistic regression to assess whether females had higher odds of an increased self-reported duration of the most severe symptom compared to males. Using a modified Poisson regression model with robust standard errors to assess the differences in clinical characteristics among COVID-19 cases.ResultsStatistical analysis revealed significant differences in the prevalence rates of various comorbidities. Among participants who reported their temperature during COVID-19 infection, more than half engaged in vitamin supplementation and regular exercise, while 4.2% remained asymptomatic. The probability of females experiencing a longer duration of severe symptoms increased compared to males [adjusted Odds Ratio (aOR) = 1.92, 95% confidence interval (CI) 1.73–2.12]. In the multivariate mixed-effects Poisson regression analysis, compared to males, females exhibited a lower prevalence rate of asymptomatic infection [adjusted prevalence ratio (aPR 0.40, 95% CI 0.28–0.58), lower prevalence of infection without therapeutic medication use (aPR 0.76, 95% CI 0.70–0.82), and lower prevalence of multiple infections (aPR 0.39, 95% CI 0.20–0.74)].ConclusionThis cross-sectional study indicates the persistence of sex differences among patients with COVID-19 who have undergone bariatric surgery. Further research is needed to explore the underlying factors contributing to this disparity.
Demand for emergency services during the COVID-19 pandemic and disease burden: a case study in Portugal
Authors: Nunes Alcina , Costa Catarina , Martins João P. , Ferreira Pedro L. , Pimenta Rui 
Published: January 2024

BackgroundThe COVID-19 pandemic brought changes in the pattern of care use. A significant increase in the volume of emergencies was expected. However, a significant decrease was observed worldwide.MethodsAn observational, analytical and cross-sectional study of all records of emergency episodes of patients aged 18 years or older admitted to the emergency services of the University of Porto Hospital Centre (2018–2022) were analysed.ResultsDuring the pandemic, a significant reduction in emergency episode admissions (up to 40% during lockdowns), an increase in pre-emergency services, and discharges from Infectious Diseases and Internal Medicine was observed. The discharges from General Practice and General Practice and Family Medicine were residual.ConclusionThe lower use and type of use of emergency services during the COVID-19 pandemic had a negative impact on the disease burden. This could be prevented in future pandemics through the development of strategies to promote confidence in the use of health resources and establishing contingency plans for virtual assistance.
Effect of larval handling on black soldier fly life history traits and bioconversion efficiency
Authors: Loiotine Zaira , Gasco Laura , Biasato Ilaria , Resconi Andrea , Bellezza Oddon Sara 
Published: January 2024

IntroductionThe black soldier fly is considered the most promising insect species for mass production; however, information on the effects of handling, which is unavoidable during experimental trials and rearing practices, is still limited.Materials and methodsTo address this gap, three different manipulation intensities were tested on 100 6-day-old larvae per replica (6 replicates/treatments) fed on Gainesville diet: (1) hard-handled (HH), larvae underwent continuous manipulation until the end of larval stage, (2) soft-handled (SH), larvae were manipulated after the appearance of the first prepupa, (3) no-handled (NH), larvae remained untouched. Every 4 days from the beginning to the end of the larval stage, the manipulations lasted 30 min and occurred under laboratory conditions (20°C). During the sampling operations, at least 30 larvae were randomly extracted, washed, dried, and weight-mimicked. At the end of larval stage, all the boxes remained untouched until the adult fly stage, and the emergency rate and sex ratio were evaluated on dead flies. Data were statistically analyzed using IBM SPSS V20.0.0 software and the considered significance level was p &lt; 0.05.ResultsThe larval stage lasted 8.2 days for both HH and SH (p &gt; 0.05). Despite the HH larvae being the most manipulated, no difference was also observed in final weight (HH, 160 mg; SH, 150 mg; p &gt; 0.05) and survival rate (HH, 96.2%; SH, 94.5%; p &gt; 0.05). The manipulation did not influence the bioconversion capacity of the larvae (bioconversion efficiency corrected for the residue: HH, 14.3%; SH, 12.91%; reduction rate: HH, 58.4%; SH, 55.9%; waste reduction index: HH, 7.28%/day; SH, 7.25%/day; p &gt; 0.05). Finally, the development time from larva to fly (about 20.7; p &gt; 0.05), the emergency rate (NH: 92.8%; SH: 89.5%; HH: 82.7%) and sex ratio (~1.2% to male flies) were not affected by the handling (p &gt; 0.05).DiscussionIn conclusion, the handling procedures used in the current study did not influence the life history traits of the black soldier fly. However, further studies are needed to evaluate if different experimental protocols on various scales, the colony strain or other handling procedures may suggest a different scenario or confirm the results.
Expanding the Distribution of Prosthechea jauana (Orchidaceae) in the Pantepui and Highlighting the Urgent Need for Conservation Strategies in the Region in Face of Climate Change
Authors: Vieira Tiago L. , Barbosa-Silva Rafael G. , Acosta André L. , van den Berg Cássio 
Published: January 2024

Prosthechea jauana has been recognized as an orchid species endemic to the Venezuelan tepui. The first record of P. jauana in Brazil is presented here, also from a tepui in the Southern phytogeographical district of Pantepui in the Serra do Aracá, at the northern border of the Amazonas state. A detailed morphological description and images of the specimen are presented, as well as an updated distribution map, preliminary conservation status assessment, and taxonomic notes about the species. In addition, we provide species’ distribution models for P. jauana based on current and future bioclimatic data. Future projections suggest that the geographic distribution of P. jauana will likely be severely affected, with ~79% of its suitable habitat being reduced by 2041–2060 and ~92% by 2061–2080. Prosthechea jauana could represent a flag species and an example of how climate change may affect the endemic Pantepui flora.
Relationship between Cumulative Temperature and Light Intensity and G93 Parameters of Isoprene Emission for the Tropical Tree Ficus septica
Authors: Oku Hirosuke , Iqbal Asif , Oogai Shigeki , Inafuku Masashi , Mutanda Ishmael 
Published: January 2024

The most widely used isoprene emission algorithm, G93 formula, estimates instantaneous leaf-level isoprene emission using the basal emission factor and light and temperature dependency parameters. The G93 parameters have been suggested to show variation depending on past weather conditions, but no study has closely examined the relationship between past meteorological data and the algorithm parameters. Here, to examine the influence of the past weather on these parameters, we monitored weather conditions, G93 parameters, isoprene synthase transcripts and protein levels, and MEP pathway metabolites in the tropical tree Ficus septica for 12 days and analyzed their relationship with cumulative temperature and light intensity. Plants were illuminated with varying (ascending and descending) light regimes, and our previously developed Ping-Pong optimization method was used to parameterize G93. The cumulative temperature of the past 5 and 7 days positively correlated with CT2 and α, respectively, while the cumulative light intensity of the past 10 days showed the highest negative correlation with α. Concentrations of MEP pathway metabolites and IspS gene expression increased with increasing cumulative temperature. At best, the cumulative temperature of the past 2 days positively correlated with the MEP pathway metabolites and IspS gene expression, while these factors showed a biphasic positive and negative correlation with cumulative light intensity. Optimized G93 captured well the temperature and light dependency of isoprene emission at the beginning of the experiment; however, its performance significantly decreased for the latter stages of the experimental duration, especially for the descending phase. This was successfully improved through separate optimization of the ascending and descending phases, emphasizing the importance of the optimization of formula parameters and model improvement. These results have important implications for the improvement of isoprene emission algorithms, particularly under the predicted increase in future global temperatures.
RESEARCH OF THE BINDER SYSTEM STRUCTURE BASED ON THERMAL ACTIVATED EXPANDED CLAY DUST
Authors: Knyazeva S. , Yakovlev G. , Bur'yanov A. , Zhukov A. , Kirshin I. 
Published: January 2024

The production of Portland cement is associated with a high consumption of mineral raw materials and significant emissions of carbon dioxide into the atmosphere. Therefore, the partial replacement of cement with technogenic mineral additive in cement compositions is a rational way of utilizing production waste. Besides, the use of industrial waste products as mineral additives allows solving environment problems and reducing the consumption of primary natural resources.
This paper presents the study on the hydraulic activity of thermally activated expanded clay dust used as an active mineral additive in cement compositions. Expanded clay dust is an industrial waste formed during the production of ceramsite gravel, and captured in the dust cleaning systems of kilns: dust chambers, cyclones, filters.
A comprehensive study of the composition, containing expanded clay dust and water, was carried out using the IR spectral analysis, differential scanning calorimetry and scanning electron microscopy with X-ray microanalysis.
It was established that the strength of baked samples increased by 80% after immersion in water. The main hydration products of baked expanded clay dust are three types of compounds - fibrous crystals of calcium hydrosulfoaluminate, calcium hydroaluminates in the form of cruciform twins, amorphized spherulite-like formations based on low-base calcium silicate hydrates.
MOBILE ROBOT MOTION CONTROL FOR DIFFERENT PATHS ON THE BASIS OF THE PRINCIPLE OF REDUCTION OF THE THEORY OF FUZZER
Authors: Lazarev M. , Ezhkova V. 
Published: January 2024

The object of the study is the control of the movement of a mobile robot along a line. To build automatic control systems for robots, various algorithms are used, for example, PID controllers, as well as algorithms based on fuzzy logic methods. Methods of the fuzzy theory form one of the universal approaches to the analysis and modeling of applied problems, including in matters of robot control.
In any study, problems arise immediately as soon as events (facts) are accepted as fuzzy, for example, due to inaccurate measurement, fuzzy description, etc. The concept of fuzziness is intuitively clear to everyone, but its formalization causes difficulties, which are always of a fundamental nature. Consideration of the foundations of the theory is caused by the search for possible solutions to problems in the experimental part of the study, which addresses the issues of speed regulation and dynamic accuracy of the movement of a mobile robot.
The article puts forward a hypothesis about the effectiveness of the method of controlling the movement of a mobile robot based on the fuzzy theory in comparison with the PID controller. To substantiate the hypothesis, a description of the movement of the robot in terms of fuzzy theory is given, the features of the movement of the robot depending on the type of tracks are considered, a fragment of the program for implementing a controller based on fuzzy logic is presented, and a number of experiments are carried out.
Experimental verification showed a more stable and faster movement of the robot along the tracks and confirmed the hypothesis of the study. The results of the experiments made it possible to correct the fuzzy inference rules and the robot motion control program. The results obtained open up new possibilities for the wide application of fuzzy theory in robotics.
Parada cardiorrespiratória em raquianestesia – relato de caso
Authors: Siqueira Lyza Alencar , Vieira Raquel Cristina Freire de Deus 
Published: January 2024

A raquianestesia é uma técnica anestésica considerada segura devido ao baixo índice de complicações. No entanto, apesar de infrequentes, alguns riscos e efeitos indesejados podem ser relacionados a essa técnica. Como exemplo, pode-se citar as repercussões no sistema cardiovascular, que pode culminar em parada cardiorrespiratória (PCR). A PCR na raquianestesia é algo incomum, tendo cerca de 0,4 a 7 casos a cada 10.000 anestesias. O objetivo deste artigo é relatar o caso de paciente que apresentou episódio de parada cardiorrespiratória após a raquianestesia em uma cirurgia ortopédica de urgência. Conclui-se que a parada cardiorrespiratória em raquianestesia é um evento multifatorial que, mesmo com a identificação precoce desses fatores, pode ser inevitável.
Ganacias de peso de bovinos en pastoreo en la epoca seca en el trópico de México
Authors: Quiroz Javier Francisco Enríquez , Aguilar Eduardo Daniel Bolaños , Islas Abraham Fragoso , Lagunes Maribel Montero , Vadillo Julio Cesar Vinay 
Published: January 2024

El objetivo fue conocer el rendimiento de forraje y ganancias de peso de bovinos en pastoreo en una pradera de gramínea en monocultivo y en asociación gramínea-leguminosa en la época seca del año. El estudio se realizó en el Campo Experimental La Posta, en Medellín, Veracruz, México. En mayo 2018 se establecieron 4 hectáreas de praderas, 2 hectáreas fueron para monocultivo, y 2 hectáreas para la asociación gramínea-leguminosa. Las especies establecidas fueron; Mombaza Megathyrsus maximus, Kudzú Pueraria phaseoloides y Clitoria ternatea. El pastoreo de becerros se realizó durante la época seca feb – mayo del 2020. Se empleó un pastoreo rotacional de 14/42 días de ocupación y descanso. Una vez estabilizado el pastoreo se inició con las evaluaciones. En los animales se evaluó la ganancia de peso vivo, y en la pradera la disponibilidad de materia verde seca de la gramínea (MVSG), la leguminosa (MVSL), material muerto (MMG), contenido de proteína, FDN, FDA, lignina y cenizas de los componentes antes descritos. Como resultados, las ganancias de peso de los animales no fueron diferentes (P>0.05) entre tratamientos, pero superiores a los 500 g/animal/día. La carga animal promedio fue 0.87 UA, lo cual fue acorde a la disponibilidad de forraje. No fue posible observar los beneficios que tienen las leguminosas en la producción animal, ya que la disponibilidad fue baja. La composición química de la biomasa fue similar entre tratamientos (P>0.05) el porcentaje de proteína cruda en la MVSG y MMG tuvo promedios de 7.86 y 3.07%, respectivamente y 12.86% la biomasa de leguminosa. Se concluye que el pasto Mombaza permitió importantes ganancias de peso de becerros en pastoreo (600 g/animal/día) en la época seca del año, aun cuando la disponibilidad de la leguminosa en la pradera fue baja.