bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral Hepatitis: HBV-HCV co-infection
Authors: Ahmed Syed Minhaj Uddin , Quazi Manjurul Haque  , Kazi Shihab Uddin  , Md Zulfikar Ali  
Published: January 2024

Co-infection with HBV and HCV is a complex clinical existence which estimated prevalence is reported 0.7% to 16% worldwide. HCV superinfection is very common due to viral replication in HCV is more dominant over HBV. Most of the clinical studies reported that disease progression is faster in HBV and HCV co-infected patients in compare to those with mono-infection. Therefore, early diagnosis and proper treatment is important for withholding the disease progression. Here a case of 45 years old male with fever, anorexia, vomiting and mucus mixed stool. HBsAg and anti-HCV are positive. USG of whole abdomen suggesting chronic liver disease with chronic kidney disease. Endoscopy of upper GIT revealed grade III esophageal varices. There are no established guidelines for treatment of HBV-HCV co-infection. Only symptomatic treatment was given.
KYAMC Journal Volume: 14, No: 03, October 2023: 178-180.
Analisis Perancangan Stasiun Kerja dalam Memproduksi Produk Inalcafa Jacket dengan Lima Metode Line Balancing
Authors: Kusuma Harun Indra , Purnomo Hadi 
Published: January 2024

Perencanaan proses adalah prosedur untuk menentukan operasi atau tindakan yang diperlukan untuk mengubah materi dari satu bentuk ke bentuk yang lain. Adapun penelitian ini memiliki enam tujuan yaitu dapat membuat lembar rencana proses produk, precedence diagram, assembly chart, bill off material, operating process chart dan melakukan penyusunan stasiun kerja melalui lima metode line balancing. Metode line balancing adalah metode yang tepat untuk meningkatan keefisiensian dari suatu sistem kerja. Agar proses produksi sangat efisien, diperlukan metode-metode line balancing. Metode yang digunakan adalah, metode Ranked Postional Weight (RPW), metode Mirror RPW, metode Largest Candidate Rule (LCR), metode J.Wagon dan metode Region Approach. Adapun metode line balancing yag terbaik yaitu metode RPW & mirror RPW dengan hasil line efficency sebesar 86,67% & smoothing index sebesar 7. Semakin besarnya line efficiency makan akan semakin baik pula hasil perancangan stasiun kerja maupun semakin rendah smoothing index akan berpengaruh terhadap baiknya perancangan stasiun kerja tersebut.
Development of Engineering Team Performance Management Applications in Apartments Using Extreme Programming Methods
Authors: Sihombing Denny Jean Cross 
Published: January 2024

This research aims to analyze and develop a performance management application for a team of technicians in an apartment using the Extreme Programming (XP) method. The initial phase involved in-depth data collection on the technician team's needs, challenges, and dynamics. Next, the application was developed with XP principles, providing features such as task tracking, job assignments, real-time status updates, and daily performance reporting. The final stage involved analyzing technology acceptance through internal trials and collecting feedback from the technician team and potential users. Technology acceptance simulations with data showed that the app successfully coped with operational scenarios and received positive feedback. The application was tested by users, with the number of users being 50% of the total number of users, with a user satisfaction rate of 85%. The conclusions of this study indicate that the engineering team successfully accepted the application, has the potential to improve performance management efficiency, and contributes to the understanding of the application of XP in application development for the property industry.
PENGARUH DISIPLIN DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN FARMERS MARKET ONE BELPARK JAKARTA SELATAN
Authors: Harsono Yhonanda , Sugiyanto Eko , Pertiwi Indah 
Published: January 2024

Tujuan penelitian ini adalah untuk mengetahui seberapa pengaruh disiplin dan motivasi kerja terhadap kinerja karyawan Farmers Market One Belpark Jakarta Selatan. Metode yang digunakan dalam penelitian ini adalah metode Kuantitatif Asosiatif. Teknik pengambilan sampel menggunakan sampling jenuh dimana seluruh populasi dijadikan responden dan diperoleh sampel dalam penelitian ini berjumlah 52 responden. Analisis data menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi berganda, Uji Koefisien Korelasi berganda, Uji Koefisien Determinasidan uji hipotesis (Uji t dan Uji f). Berdasarkan hasil perhitungan di peroleh nilai t hitung > t tabel atau (6,289 >2,009). Dengan demikian H01 ditolak dan Ha1 diterima, artinya terdapat pengaruh yang signifikan secara parsial antara disiplin kerja terhadap kinerja karyawan Farmers Market One Belpark Jakarta Selatan . Berdasarkan hasil perhitungan di peroleh nilai t hitung > t tabel atau (8,620 > 2,009). Dengan demikian H02ditolak dan Ha2diterima, artinya terdapat pengaruh yang signifikan secara parsial antara motivasi kerja terhadap kinerja karyawan Farmers Market One Belpark Jakarta Selatan. Berdasarkan hasil perhitungan Disiplin (X1) dan Motivasi (X2) berpengaruh positif terhadap kinerja karyawan dengan persamaan Y = 5,930 + 0,088X1 - 0,184X2 nilai koefisien korelasi atau tingkat pengaruh antara variabel bebas dan terikat diperoleh sebesar 0,794 memiliki hubungan yang kuat. Dengan koefisien korelasi atau determinasi pengaruh secara simultan sebesar 0,630 atau sebesar 63% dan sisanya sebesar 37% di pengaruhi oleh faktor lain. Uji hipotesis di peroleh F hitung > F tabel atau (41,674 > 3,19), Dengan demikian H03 di tolak dan Ha3 diterima artinya terdapat pengaruh yang signifikan secara simultan antara disiplin (X1) dan Motivasi kerja (X2) terhadap kinerja karyaawan (Y) pada Farmers Market One Belpark Jakarta Selatan.
Prevalence of Urinary Incontinence and Coping Attitudes in Women With and Without Incontinence in Turkey
Authors: DÖNMEZ Sevgül , TÜMER Adile , AKDOLUN BALKAYA Nevin 
Published: January 2024

Aim: Coping strategies are thought to be important in dealing with a problem that affects women's well-being and quality of life, such as incontinence (UI). This study was done to investigate the incidence of UI and coping attitudes in women without and with UI in Turkey.
Material and Methods: The descriptive study was carried out with 417 women who were applied in a Healthy Life Center located in Turkey. The study data were obtained using the International Consultation on Incontinence Questionnaire (Short Form) (ICIQ-SF) and Coping Orientations to Problems Experienced (COPE).
Results: It was found that 34.8% of women had UI. It was determined that women used more common problem and emotion-focused coping attitudes” which are functional coping attitudes. It was found that women with UI used "withdrawal" which are problem-functional coping attitude "acceptance" which are emotion-functional coping attitude and "denial" and "behavioral disengagement" which are dysfunctional coping attitudes more than women without UI.
Conclusion: It was determined that one third of the women had UI and they used more common problem-and emotion-focused coping attitudes. Although urinary incontinence has a chance of being treated, it is a condition that has major physical, psychosocial and economic effects on society, and is often reported to the health institution by women, and treatment is delayed.
Pendidikan Karakter dalam Perspektif Al-Qur’an (Analisis Corak Tafsir Tarbawi dalam Qs. Luqman Ayat 12-19)
Authors: Farid Miftah , Al-Kautsary Muhammad Iqbal , Sidik Asep Hilmi Muhamad 
Published: January 2024

Education plays a crucial role as a means to enhance the quality of human resources. However, the challenge faced by education today is the occurrence of moral decadence. The Quran, as the source of Islamic teachings related to all aspects of human life, contains answers to various issues, including the educational aspect. Nevertheless, not everyone can easily understand it. Hence, commentators or experts in interpretation, known as mufassir, emerged to facilitate our understanding of the Quran. The verses under study in this research are from Surah Luqman, specifically from verse 12 to verse 19. The research applies a literature approach, where information and data are gathered from various library sources. The data is divided into two types: primary data from the Tafsir Al-Mishbah by M. Quraish Shihab, and secondary data from relevant articles and books. The analysis process involves data collection, classification based on the research formula, citation of references to organize findings, abstraction to obtain concrete information, and interpretation of data with conclusions drawn. The result of this research is the pattern of tarbawi interpretation with a specific orientation toward interpreting Quranic verses related to education and educational goals. One form of tarbawi interpretation is M. Quraish Shihab's interpretation of Surah Luqman verses 12-19, which discusses the teaching of wisdom and advice provided by Luqman to his son. This interpretation is relevant to modern character education values, supplemented with Islamic teachings. In the Islamic perspective, character is not only identified with morality. Noble character or morality is produced through the application of Sharia (worship and transactions) based on a strong foundation of faith ('aqidah).
Keywords: Education Character, Al-Qur’an, Analyizing Tafsir Tarbawi
El Fenómeno Emprendedor y La Convergencia Norte-Sur en Europa: evidencias del Obse rvatorio GEM.
Authors: Ruiz Navarro José , García Montesinos Cristina 
Published: January 2024

La preocupación por el emprendimiento y su relación con la salida de la crisis económica está presente en la mayoría de los discursos de los responsables políticos de Europa y hay un amplio consenso en que las iniciativas emprendedoras de calidad, su desarrollo y consolidación, están estrechamente relacionadas con la salida de la crisis, el crecimiento económico y la creación de empleo. Sin embargo, estos planteamientos no tienen suficientemente en consideración las diferencias territoriales en Europa. En esta investigación se ofrece una serie de evidencias del fenómeno emprendedor desde la perspectiva territorial norte-sur de Europa y se plantea que la convergencia europea no se está produciendo en esta materia. La información de las dos zonas geográficas europeas contempladas, los países Nórdicos (Dinamarca, Finlandia, Islandia, Noruega y Suecia) y los países Medi-terráneos (España, Grecia, Italia y Portugal) ha sido extraída del observatorio Global Entrepreneurship Monitor (GEM).
Cytokine and microbiota profiles in obesity-related hypertension patients
Authors: Aguirre-García María Magdalena , Amedei Amedeo , Hernández-Ruiz Paulina , Gómez-García Ana Pamela , Niccolai Elena , Moreno-Rodríguez Aura M. , Pinto-Cardoso Sandra , Alviter-Plata Adriana , Escalona-Montaño Alma R. , Ordaz-Robles Erick R. , González-Salazar María del C. , Springall Del Villar Rashidi , Berrios-Bárcenas Enrique A. , Ávila-Vanzzini Nydia 
Published: January 2024

BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension.
Research on porosity characterization methods of shale oil reservoirs in Lianggaoshan Formation, Sichuan Basin
Authors: Su Shute , Wang Liang , Li Jun , Lu Jing , Luo Yang , Jia Jun 
Published: January 2024

Shale oil, an important component of unconventional oil and gas resources, mainly exists in the storage spaces such as shale pores, microfractures, etc. Porosity is commonly used to quantitatively describe the storage space of shale oil and is a key parameter in reservoir evaluation. However, there are significant differences in the results by existing experimental methods for porosity measurement, and moreover, it is difficult to compare the porosity obtained by the experimental measurement method with the logging calculation method. It is urgent to explore reasons for the differences in porosity measurement between various porosity experiments and logging calculations of the shale oil reservoir, and propose an effective method for shale oil reservoir to characterize porosity. In this research, core samples of shale oil reservoirs from the Lianggaoshan Formation of the Sichuan Basin were selected to measure the porosity by means of experimental methods including helium gas charging, saturation liquid method, nuclear magnetic resonance (NMR), etc. Meanwhile, porosity was calculated using the combination method of lithology scanning (LS) logging and conventional logging as well as the NMR logging method. Subsequently, porosity experimental results and logging calculation results were compared to clarify the applicability of various porosity characterization methods. The research results indicate that: 1) The porosity measurement results by the saturation liquid method and the NMR experimental method are close, both greater than that using the helium gas charging method; 2) The hydrogen signal of the dry-state sample is significant in the NMR experiment, mainly originating from organic matter and clay minerals; 3) The NMR short relaxation component in the water-saturated state primarily reflects the signal of organic matter and clay mineral matrix, while the long relaxation component reflects the pore fluid component; 4) After deducting the NMR signal of the dry-state core, the core NMR porosity measurement results under the water-saturated state agree well with that using the saturation liquid method, which is an indicative of effective reservoir porosity; 5) The NMR logging is limited by its echo spacing and cannot reflect the signal from organic matter and the crystal water in clay minerals at T2 &lt; 0.3 ms. Taken together, the porosity measurement method of subtracting the dry-state NMR signal from the water-saturated state NMR signal is considered effective and can be used to reflect the porosity of shale oil reservoirs in the Lianggaoshan Formation of the Sichuan Basin.
Master–slave game operation scheduling strategy of an integrated energy system considering the uncertainty of wind and solar output
Authors: Zhang Xiaohan , Shen Jin 
Published: January 2024

Introduction: With the development of the energy market and the gradual rise of emerging market players, the linkage of interests between energy sources and loads in the Integrated Energy System (IES) has become increasingly complex. Additionally, the reliability of the system has been impacted by the growing proportion of renewable energy output.Methods: To address the challenges posed by the above issues. This paper first proposes an operational strategy for an integrated energy system that incorporates the uncertainty of wind and solar output using a master-slave game approach. To enhance system robustness and cost-effectiveness, the paper introduces the information gap decision theory (IGDT). Second, building on this foundation, the system operator is considered as the leader, adding a tiered carbon trading mechanism and cloud energy storage system, and building a system revenue maximization model. Then, the user is regarded as the follower, and an optimization model is developed based on integrated demand response (IDR). Finally, the two-layer model is converted into a mixed-integer linear programming problem (MILP) to be solved by the Karush-Kuhn-Tucker conditions (KKT) combined with the big M method.Results: The analysis of the example shows that according to the difference of the decision maker’s attitude towards risk, different scheduling schemes can be obtained through the two perspectives of risk-seeking and risk-avoiding, which can provide guidance for the dynamic operation of the system, and at the same time, the users can be guided by the energy differentials to reasonably use the energy under this strategy.Discussion: Therefore, the proposed strategy in this paper can balance the economy and robustness of the system.
Antitumoral effect of local injection of TLR-9 agonist emulsified in Lipiodol with systemic anti-PD-1 in a murine model of colorectal carcinoma
Authors: Grindel Anne-Laure , Fretellier Nathalie , Soares Miguel , Bouzakher Nabiha , Millot Maysounabe Vincent , Santus Robin , Bawa Olivia , Wintrebert Melody , Couquelet Clémence , Robert Philippe , Emile Jean-Francois , Capron Claude 
Published: January 2024

IntroductionLocal treatments of cancer, including transarterial chemoembolization, could enhance responses to systemic immune checkpoint inhibitors such as anti-PD-1 antibodies. Lipiodol, a radiopaque oil, is widely used for transarterial chemoembolization as a tumor-targeting drug carrier and could be used in emulsion with immunomodulators. This study aimed at evaluating the antitumoral effect of intra-tumoral injection of Lipiodol-immunomodulator emulsions combined with systemic anti-PD-1 therapy in a murine model of colorectal carcinoma. MethodMice (male BALB/c) with anti-PD-1-resistant subcutaneous CT26 tumors were injected with immunomodulators, emulsified or not with Lipiodol (N=10-12/group).ResultsThe TLR-9 agonist CpG displayed antitumor effects, while Poly I:C and QS21 did not. The Lipiodol-CpG emulsion appeared to be stable and maintained CpG within tumors for a longer time. Repeated intra-tumoral injections, combined with anti-PD-1, induced responses towards the tumor as well as to a distant metastatic-like nodule. This treatment was associated with an increase in proliferative CD8+ T cells and of IFN-γ expression, a decrease in proliferative regulatory T cells but also, surprisingly, an increase in myeloid derived suppressor cells.ConclusionsLocal administration of CpG emulsified with Lipiodol led to an effective antitumoral effect when combined to systemic anti-PD-1 therapy. Lipiodol, apart from its radiopaque properties, is an efficient drug-delivery system. The formulated oil-in-water emulsion allows efficient loading and control release of CpG, which induces favorable immune modifications in this murine tumor model.
miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells
Authors: Zhou Yang , Nomigni Milène Tetsi , Gaigneaux Anthoula , Tolle Fabrice , Wright Helen L. , Bueb Jean-Luc , Bréchard Sabrina 
Published: January 2024

BackgroundNeutrophils are an important source of pro-inflammatory and immunomodulatory cytokines. This makes neutrophils efficient drivers of interactions with immune and non-immune cells to maintain homeostasis and modulate the inflammatory process by notably regulating the release of cytokines. Ca2+-dependent regulatory mechanism encompassing cytokine secretion by neutrophils are not still identified. In this context, we propose to define new insights on the role of Ca2+-binding proteins S100A8/A9 and on the regulatory role of miRNA-132-5p, which was identified as a regulator of S100A8/A9 expression, on IL-8 secretion.MethodsDifferentiated HL-60 cells, a human promyelocytic leukemia cell line that can be induced to differentiate into neutrophil-like cells, were used as a model of human neutrophils and treated with N- formyl-methionyl-leucyl-phenylalanine (fMLF), a bacterial peptide that activates neutrophils. shRNA knockdown was used to define the role of selected targets (S100A8/A9 and miRNA-132-5p) on IL-8 secretion.Results and discussionDifferent types of cytokines engage different signaling pathways in the secretion process. IL-8 release is tightly regulated by Ca2+ binding proteins S100A8/A9. miRNA-132-5p is up-regulated over time upon fMLF stimulation and decreases S100A8/A9 expression and IL-8 secretion.ConclusionThese findings reveal a novel regulatory loop involving S100A8/A9 and miRNA-132-5p that modulates IL-8 secretion by neutrophils in inflammatory conditions. This loop could be a potential target for therapeutic intervention in inflammatory diseases.
Application of three-dimensional visualization technology in phacoemulsification benefits the dry eye symptoms of patients after cataract surgery
Authors: Wu Chen , Chen Qingzhong , Zhang Guangbin 
Published: January 2024

PurposeTo investigate the effects of the three-dimension visualization system on dry eye in patients after cataract phacoemulsification.MethodsSeventy-one patients (104 eyes) were enrolled in this study and assigned to the conventional microscopic group (CM group) or three-dimension group (3D group). Ocular Surface Disease Index, The Schirmer I test (SIt), lipid layer thickness (LLT), noninvasive tear breakup time (NIBUT) and other factors associated with dry eye were recorded before and 1 week and 1 month after surgery. The operation time and intraoperative light intensity (ILI) were also recorded.ResultsThe ILI in the 3D group was significantly lower than that in the CM group (33% vs. 60%, p &lt; 0.01). There was an interaction (group and time) effect for first NIBUT (NIBUT-F), average NIBUT (NIBUT-Ave), tear meniscus height (TMH) and the score of eye redness (Pinteraction &lt; 0.05). The main effects of group on SIt, LLT, NIBUT-F, NIBUT-Ave and the score of eye redness were significant (Pgroup &lt; 0.05). In the CM group, SIt, LLT, NIBUT-F, NIBUT-Ave, TMH were lower than those of the 3D group, the score of eye redness was higher than that of the 3D group at 1 week and 1 month after surgery (all p &lt; 0.05). The changes in NIBUT-F and NIBUT-Ave between before surgery and 1 week after surgery showed negative correlations with ILI (p &lt; 0.01).ConclusionCompared with microscopic surgery, the 3D visualization system can provide better tear film stability for patients after cataract surgery.