bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solution strategy for sustainable additive manufacturing design problem using Pythagorean fuzzy MCGDM methodology
Authors: Momena Alaa Fouad 
Published: February 2024

AbstractTo solve difficulties involving various groups’ decision-making problems, this work has been proposed to develop a logical aggregation approach to aggregate decision-makers’ crisp data into Pythagorean fuzzy numbers. By combining the established strategy with the Pythagorean fuzzy TOPSIS method, a hybrid Pythagorean fuzzy multiple criteria group decision-making methodology is presented. Based on fuzzy rules inference and the Takagi–Sugeno technique, a novel function is created to represent the degrees of uncertainty in decision-makers’ data. As an example, the material selection process in practical additive manufacturing designs is provided to show how the proposed methodology may be applied to actual applications. Sensitivity analysis is used to evaluate the effectiveness of the suggested methodology. The outcomes demonstrate that the plan was successful in producing a PFN that accurately reflects the decision-maker’s knowledge.
Pseudospheres: combinatorics, topology and distributed systems
Authors: Alberto Luis 
Published: February 2024

AbstractPseudospheres are simplicial complexes defined in the late 1990s to model some aspects of distributed systems. Since then, combinatorial properties of pseudospheres combined with topological properties have been very useful to derive distributed computability results. The goal of this paper is to study pseudospheres in more depth as mathematical objects and to give an overview of the properties that have been used in distributed computing. In this work we focus in combinatorial and topological aspects of pseudospheres. While doing so, the paper shows that these structures can be viewed from different perspectives, in addition to models of distributed computing. We show that the properties of pseudospheres that have been proved in distributed computing, as well as new ones, can be derived using combinatorial topology techniques and other combinatorial techniques taken from matroids and partial orders. A subclass of pseudospheres is related to universal bundles, and the Borsuk–Ulam theorem can be extended to apply to them.
The Transition Layer and Remnant Transition Layer of the Western Arctic Ocean: Stratification, Vertical Diffusivity, and Pacific Summer Water Heat Fluxes
Authors: Cole Sylvia T. , Roemer Peter A. 
Published: February 2024

AbstractThe exchange of heat and other tracers between the ocean interior and sea ice cover depends on vertical diffusion through the thin and strongly stratified Arctic Ocean transition layer and remnant transition layer. Ice‐Tethered Profiler observations during 2004–2021 were used to characterize and investigate the active and remnant transition layers in the Beaufort Gyre region. Transition layers evolved seasonally, with the deepest, densest, and warmest transition layers observed in spring. In a composite view, the summer mixed layer shoaled over a timescale of approximately 2 weeks, leaving behind a remnant transition layer whose stratification had already begun to weaken. The stratification maximum of the remnant transition layer continued to weaken and broaden throughout the summer, including changes associated with storm events. The weakening stratification was used to estimate an effective vertical turbulent diffusivity which ranged from 10−8 to 10−6 m2/s for individual ITP records; a value of 6 × 10−7 m2/s is representative of the Beaufort Gyre region. Vertical heat fluxes through the active and remnant transition layers were estimated over 90‐day timescales. Springtime vertical heat fluxes increased from 0.3 ± 0.3 W/m2 during 2006–2011 to 1.1 ± 0.7 W/m2 during 2017–2021. Summertime vertical heat fluxes through the remnant transition layer were somewhat less, but also increased interannually. Vertical gradients of density during spring and summer, and so diffusion of density through the active and remnant transition layers, did not increase interannually. Pacific Summer Water warming has increased ocean to ice heat fluxes, which may continue to become more significant in the future.
The Structure and Dynamics of an Estuarine Tidal Intrusion Front
Authors: Geyer W. R. , Ralston D. K. , Haller M. C. , Bassett C. , Honegger D. 
Published: February 2024

AbstractTidal intrusion fronts are surface convergences that occur at constrictions in estuaries during the flood tide, separating incoming higher‐salinity water from lower‐salinity, stratified estuarine water. Previous observations of tidal intrusion fronts describe a V‐shaped planform, with the apex of the V pointing into the estuary, however the significance of this structure has not been previously explained. Observations near the mouth of the James River estuary during the flood tide reveal the development of a quasi‐steady, V‐shaped front. Considering a reference frame oriented normal to the front, the velocity and density structure are consistent with gravity‐current dynamics, but the oblique orientation of the front relative to the impinging flow indicates strong, along‐front shear, which results from vorticity produced by flow separation at the lateral boundaries as well as topographic torque from upstream. The combination of convergence and along‐front shear leads to enhanced mixing, as revealed by acoustic backscatter images of shear instability and persistent subcritical gradient Richardson number in the frontal zone. Oblique fronts such as this tidal intrusion front are common features of estuaries, and they play an important role in vertical exchange due to subduction and mixing of surface water.
TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target
Authors: Shi Lingxue , Wang Xiaohong , Guo Shang , Gou Hongyan , Shang Haiyun , Jiang Xiaojia , Wei Chunxian , Wang Jia , Li Chao , Wang Lihong , Zhao Zengren , Yu Weifang , Yu Jun 
Published: February 2024

AbstractCopy number alterations are crucial for the development of gastric cancer (GC). Here, we identified Transmembrane Protein 65 (TMEM65) amplification by genomic hybridization microarray to profile copy-number variations in GC. TMEM65 mRNA level was significantly up-regulated in GC compared to adjacent normal tissues, and was positively associated with TMEM65 amplification. High TMEM65 expression or DNA copy number predicts poor prognosis (P < 0.05) in GC. Furtherly, GC patients with TMEM65 amplification (n = 129) or overexpression (n = 78) significantly associated with shortened survival. Ectopic expression of TMEM65 significantly promoted cell proliferation, cell cycle progression and cell migration/invasion ability, but inhibited apoptosis (all P < 0.05). Conversely, silencing of TMEM65 in GC cells showed opposite abilities on cell function in vitro and suppressed tumor growth and lung metastasis in vivo (all P < 0.01). Moreover, TMEM65 depletion by VNP-encapsulated TMEM65-siRNA significantly suppressed tumor growth in subcutaneous xenograft model. Mechanistically, TMEM65 exerted oncogenic effects through activating PI3K-Akt-mTOR signaling pathway, as evidenced of increased expression of key regulators (p-Akt, p-GSK-3β, p-mTOR) by Western blot. YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase) was identified as a direct downstream effector of TMEM65. Direct binding of TMEM65 with YWHAZ in the cytoplasm inhibited ubiquitin-mediated degradation of YWHAZ. Moreover, oncogenic effect of TMEM65 was partly dependent on YWHAZ. In conclusion, TMEM65 promotes gastric tumorigenesis by activating PI3K-Akt-mTOR signaling via cooperating with YWHAZ. TMEM65 overexpression may serve as an independent new biomarker and is a therapeutic target in GC.
circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation
Authors: Wang Yan , Wang Yihao , Wu Chunjie , Ji Yunfei , Hou Pingfu , Wu Xueqing , Li Zhongwei , Li Minle , Chu Sufang , Ning Qianqian , Xu Bo , Zheng Junnian , Bai Jin 
Published: February 2024

AbstractThe metastasis of non-small cell lung cancer (NSCLC) is the leading death cause of NSCLC patients, which requires new biomarkers for precise diagnosis and treatment. Circular RNAs (circRNAs), the novel noncoding RNA, participate in the progression of various cancers as microRNA or protein sponges. We revealed the mechanism by which circEPB41L2 (hsa_circ_0077837) blocks the aerobic glycolysis, progression and metastasis of NSCLC through modulating protein metabolism of PTBP1 by the E3 ubiquitin ligase TRIP12. With ribosomal RNA-depleted RNA seq, 57 upregulated and 327 downregulated circRNAs were identified in LUAD tissues. circEPB41L2 was selected due to its dramatically reduced levels in NSCLC tissues and NSCLC cells. Interestingly, circEPB41L2 blocked glucose uptake, lactate production, NSCLC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically, acting as a scaffold, circEPB41L2 bound to the RRM1 domain of the PTBP1 and the E3 ubiquitin ligase TRIP12 to promote TRIP12-mediated PTBP1 polyubiquitylation and degradation, which could be reversed by the HECT domain mutation of TRIP12 and circEPB41L2 depletion. As a result, circEPB41L2-induced PTBP1 inhibition led to PTBP1-induced PKM2 and Vimentin activation but PKM1 and E-cadherin inactivation. These findings highlight the circEPB41L2-dependent mechanism that modulates the “Warburg Effect” and EMT to inhibit NSCLC development and metastasis, offering an inhibitory target for NSCLC treatment.
Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model
Authors: Locke Emily , Flores-Garcia Yevel , Mayer Bryan T. , MacGill Randall S. , Borate Bhavesh , Salgado-Jimenez Berenice , Gerber Monica W. , Mathis-Torres Shamika , Shapiro Sarah , King C. Richter , Zavala Fidel 
Published: February 2024

AbstractNew strategies are needed to reduce the incidence of malaria, and promising approaches include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria vaccine, RTS,S/AS01, it is essential to standardize preclinical assays to measure the potency of next-generation vaccines against this benchmark. We focus on RTS,S/AS01-induced antibody responses and functional activity in conjunction with robust statistical analyses. TransgenicPlasmodium bergheisporozoites containing full-lengthP. falciparumCSP (tgPb-PfCSP) allow two assessments of efficacy: quantitative reduction in liver infection following intravenous challenge, and sterile protection from mosquito bite challenge. Two or three doses of RTS,S/AS01 were given intramuscularly at 3-week intervals, with challenge 2-weeks after the last vaccination. Minimal inter- and intra-assay variability indicates the reproducibility of the methods. Importantly, the range of this model is suitable for screening more potent vaccines. Levels of induced anti-CSP antibody 2A10 equivalency were also associated with activity: 105 μg/mL (95% CI: 68.8, 141) reduced liver infection by 50%, whereas 285 μg/mL (95% CI: 166, 404) is required for 50% sterile protection from mosquito bite challenge. Additionally, the liver burden model was able to differentiate between protected and non-protected human plasma samples from a controlled human malaria infection study, supporting these models’ relevance and predictive capability. Comparison in animal models of CSP-based vaccine candidates to RTS,S/AS01 is now possible under well controlled conditions. Assessment of the quality of induced antibodies, likely a determinant of durability of protection in humans, should be possible using these methods.
A benchmark GaoFen-7 dataset for building extraction from satellite images
Authors: Chen Peimin , Huang Huabing , Ye Feng , Liu Jinying , Li Weijia , Wang Jie , Wang Zixuan , Liu Chong , Zhang Ning 
Published: February 2024

AbstractAccurate building extraction is crucial for urban understanding, but it often requires a substantial number of building samples. While some building datasets are available for model training, there remains a lack of high-quality building datasets covering urban and rural areas in China. To fill this gap, this study creates a high-resolution GaoFen-7 (GF-7) Building dataset utilizing the Chinese GF-7 imagery from six Chinese cities. The dataset comprises 5,175 pairs of 512 × 512 image tiles, covering 573.17 km2. It contains 170,015 buildings, with 84.8% of the buildings in urban areas and 15.2% in rural areas. The usability of the GF-7 Building dataset has been proved with seven convolutional neural networks, all achieving an overall accuracy (OA) exceeding 93%. Experiments have shown that the GF-7 building dataset can be used for building extraction in urban and rural scenarios. The proposed dataset boasts high quality and high diversity. It supplements existing building datasets and will contribute to promoting new algorithms for building extraction, as well as facilitating intelligent building interpretation in China.
Chromosome-level genome assembly and annotation of rare and endangered tropical bivalve, Tridacna crocea
Authors: Li Jun , Ma Haitao , Qin Yanpin , Zhao Zhen , Niu Yongchao , Lian Jianmin , Li Jiang , Noor Zohaib , Guo Shuming , Yu Ziniu , Zhang Yuehuan 
Published: February 2024

AbstractTridacna crocea is an ecologically important marine bivalve inhabiting tropical coral reef waters. High quality and available genomic resources will help us understand the population structure and genetic diversity of giant clams. This study reports a high-quality chromosome-scale T. crocea genome sequence of 1.30 Gb, with a scaffold N50 and contig N50 of 56.38 Mb and 1.29 Mb, respectively, which was assembled by combining PacBio long reads and Hi-C sequencing data. Repetitive sequences cover 71.60% of the total length, and a total of 25,440 protein-coding genes were annotated. A total of 1,963 non-coding RNA (ncRNA) were determined in the T. crocea genome, including 62 micro RNA (miRNA), 58 small nuclear RNA (snRNA), 83 ribosomal RNA (rRNA), and 1,760 transfer RNA (tRNA). Phylogenetic analysis revealed that giant clams diverged from oyster about 505.7 Mya during the evolution of bivalves. The genome assembly presented here provides valuable genomic resources to enhance our understanding of the genetic diversity and population structure of giant clams.
Functional trait dataset of European groundwater Amphipoda: Niphargidae and Typhlogammaridae
Authors: Premate Ester , Fišer Cene 
Published: February 2024

AbstractGroundwater represents a vast, but mostly hidden and inaccessible ecosystem. Although often overlooked in freshwater research, groundwater organisms form a significant part of freshwater biodiversity, whereas their functions are crucial in different ecosystem processes. Knowledge on functional traits is generally lacking for most groundwater species worldwide, yet European groundwater amphipods, particularly the family Niphargidae, are an exception. They are well-researched and used as a model system in ecological and evolutionary studies. We focused on this group to assemble a first functional trait dataset dedicated to groundwater species. We gathered data for eight morphological functional traits quantified through 27 measurements for 1123 individuals which represent 180 species and 314 MOTUs. Besides functional trait data, every entry is accompanied with locality information, including habitat type, and DNA sequences if available. The structure of the dataset and data processing information provided along enable wide applicability and extension to other amphipod taxa. When coupled with phylogeny, the dataset may further enhance different aspects of groundwater research, including biodiversity patterns, community assembly processes, and trait evolution.
A dataset of behavioral measures on Chinese word production in picture naming
Authors: Feng Chen , Damian Markus F. , Qu Qingqing 
Published: February 2024

AbstractMost studies of language production have been conducted with speakers of alphabetic languages, but relatively little research has examined languages with non-alphabetic scripts, such as Chinese. Moreover, most work on language word production has investigated phonological output processing (i.e., speaking), whereas comparatively little research has focused on orthographic output, such as writing and typing. Work on non-alphabetic languages and/or written production is particularly promising, given that it speaks to universalities vs. specificity in terms of architectures and mechanisms underlying language processing across all world languages and modalities. The current article reports a dataset of word production in Chinese with spoken and written responses, which includes reaction times of 193,851 trials of naming 403 pictures obtained from 667 participants across 23 Chinese word production experiments. All data were collected in the same experimental environment and from participants with relatively homogenous characteristics, using the same protocols and parameters. The dataset enables researchers to explore how Chinese speakers produce spoken and/or written words, and to identify language-specific features underlying word production.
Precise single column resection and reconstruction with femoral head plus total hip replacement for primary malignant peri-acetabulum tumors
Authors: Yang Yongkun , Li Yuan , Liu Weifeng , Niu Xiaohui 
Published: February 2024

AbstractTo evaluate whether single acetabular column can be reserved and the effect of reconstruction with femoral head plus total hip replacement (THR) for primary malignant peri-acetabulum tumors. From 2007 to 2015, nineteen patients with primary malignant peri-acetabulum tumors were enrolled. All cases underwent single column resection with clear surgical margins. Ten of the 19 tumor’s resections were assisted by computer navigation. Femoral heads were applied to reconstruct anterior or posterior column defects; THR was used for joint reconstruction. The surgical safety, oncologic outcome and prosthesis survivorship and function were evaluated by regular follow-up. The average follow-up period was 65.9 months. Surgical margins contained wide resection in 12 cases and marginal resection in 7 cases. One patient with Ewing's sarcoma died 14 months postoperative due to lung metastasis. One case with chondrosarcoma had recurrence. One prosthesis was removed due to infection. The average MusculoSkeletal Tumor Society (MSTS) function score was 83.7%. Due to the relative small number of cases, there was no significant difference in the recurrence rate and prosthesis failure rate between the navigation group and non-navigation group. Single column resection and reconstruction with femoral head autograft plus THR is an effective, safe method with less complication rate and better functional outcome for patients with peri-acetabular tumors.
Facilitating long-term cell examinations and time-lapse recordings in cell biology research with CO2 mini-incubators
Authors: Talebipour Ali , Saviz Mehrdad , Vafaiee Mohaddeseh , Faraji-Dana Reza 
Published: February 2024

AbstractIn recent years, microscopy has revolutionized the study of dynamic living cells. However, performing long-term live cell imaging requires stable environmental conditions such as temperature, pH, and humidity. While standard incubators have traditionally provided these conditions, other solutions, like stagetop incubators are available. To further enhance the accessibility of stable cell culture environments for live cell imaging, we developed a portable CO2 cell culture mini-incubator that can be easily adapted to any x–y inverted microscope stage, enabling long-term live cell imaging. This mini-incubator provides and maintains stable environmental conditions and supports cell viability comparable to standard incubators. Moreover, it allows for parallel experiments in the same environment, saving both time and resources. To demonstrate its functionality, different cell lines (VERO and MDA-MB-231) were cultured and evaluated using various assays, including crystal violet staining, MTT, and flow cytometry tests to assess cell adhesion, viability, and apoptosis, respectively. Time-lapse imaging was performed over an 85-h period with MDA-MB-231 cells cultured in the mini-incubator. The results indicate that this device is a viable solution for long-term imaging and can be applied in developmental biology, cell biology, and cancer biology research where long-term time-lapse recording is required.
The current state of artificial intelligence generative language models is more creative than humans on divergent thinking tasks
Authors: Hubert Kent F. , Awa Kim N. , Zabelina Darya L. 
Published: February 2024

AbstractThe emergence of publicly accessible artificial intelligence (AI) large language models such as ChatGPT has given rise to global conversations on the implications of AI capabilities. Emergent research on AI has challenged the assumption that creative potential is a uniquely human trait thus, there seems to be a disconnect between human perception versus what AI is objectively capable of creating. Here, we aimed to assess the creative potential of humans in comparison to AI. In the present study, human participants (N = 151) and GPT-4 provided responses for the Alternative Uses Task, Consequences Task, and Divergent Associations Task. We found that AI was robustly more creative along each divergent thinking measurement in comparison to the human counterparts. Specifically, when controlling for fluency of responses, AI was more original and elaborate. The present findings suggest that the current state of AI language models demonstrate higher creative potential than human respondents.
Advancing spinal cord injury care through non-invasive autonomic dysreflexia detection with AI
Authors: Pancholi Sidharth , Everett Thomas H. , Duerstock Bradley S. 
Published: February 2024

AbstractThis paper presents an AI-powered solution for detecting and monitoring Autonomic Dysreflexia (AD) in individuals with spinal cord injuries. Current AD detection methods are limited, lacking non-invasive monitoring systems. We propose a model that combines skin nerve activity (SKNA) signals with a deep neural network (DNN) architecture to overcome this limitation. The DNN is trained on a meticulously curated dataset obtained through controlled colorectal distension, inducing AD events in rats with spinal cord surgery above the T6 level. The proposed system achieves an impressive average classification accuracy of 93.9% ± 2.5%, ensuring accurate AD identification with high precision (95.2% ± 2.1%). It demonstrates a balanced performance with an average F1 score of 94.4% ± 1.8%, indicating a harmonious balance between precision and recall. Additionally, the system exhibits a low average false-negative rate of 4.8% ± 1.6%, minimizing the misclassification of non-AD cases. The robustness and generalizability of the system are validated on unseen data, maintaining high accuracy, F1 score, and a low false-negative rate. This AI-powered solution represents a significant advancement in non-invasive, real-time AD monitoring, with the potential to improve patient outcomes and enhance AD management in individuals with spinal cord injuries. This research contributes a promising solution to the critical healthcare challenge of AD detection and monitoring.