bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between types of Ventricular Septal Defect and chromosomal abnormalities in Low-Risk Non-Invasive Prenatal Testing
Authors: Zhao Xiaomin , Shen Yongmei , Kong Dexuan , Li Wen , Yao Liying , Li Shanshan , Chang Ying 
Published: January 2024

Abstract
Objective
The aim of this study was to examine whether there is any association between various types of ventricular septal defect (VSD) and chromosomal abnormalities in the low-risk environment of non-invasive prenatal testing (NIPT) and to evaluate the prognosis of fetuses with different types of VSD.
Methods
From May 2017 to May 2022, Tianjin Central Obstetrics and Gynecology Hospital collected cases of prenatal diagnosis of fetal VSD by amniocentesis. Those with NIPT high-risk, such as chromosomal number abnormalities, fragment deletions or duplications, and polymorphisms, were excluded from the study. Data collected included ultrasound classification of VSD, prenatal NIPT results, copy number variations (CNVs) results, and neonatal outcomes.
Results
This study investigated the prevalence of pathogenic copy number variations (CNVs) in 74 cases, including 45 isolated ventricular septal defects (VSDs) (9 of which were muscular and 36 non-muscular) and 29 non-isolated VSDs (10 with intracardiac and 19 with extra-cardiac structural anomalies). Results revealed that the incidence of pathogenic CNVs was lower in isolated VSDs than in non-isolated VSDs in a low-risk NIPT condition (χ2 = 9.344, P = 0.002). There was no significant difference in the prevalence of pathogenic CNV between VSDs with intracardiac and extra-cardiac structural anomalies (P = 0.541). Moreover, VSDs associated with intracardiac structural anomalies had the highest rate of surgical intervention.
Conclusions
When NIPT is low-risk and VSD is isolated, the likelihood of fetal chromosomal defects is not increased. However, when there are both intra- and extracardiac structural issues in addition to VSD, the possibility of pathogenic CNV is considerably greater and therefore, invasive prenatal diagnosis is recommended. It was additionally noted that isolated muscular septal defects usually do not require surgery, which can be used as a basis for prenatal counseling regarding fetal VSD.
Stabilization of unusual platinum(III) valence state through the iodide-bridged three-center four-electron bonding
Authors: Wakizaka Masanori , Tanaka Hisaaki , Takaishi Shinya , Yamashita Masahiro 
Published: January 2024

Abstract
One of the goals in synthetic chemistry is to obtain compounds featuring unusual valence states that are stable under ambient conditions. At present, stabilizing unusual Pt(III) states is considered difficult, except through direct Pt–Pt bonding such as that in platinum-blues or organometallization using bulky ligands. Pt(III) stabilization is also very difficult in halogen-bridged metal complex chains (MX-Chains). Herein, the iodide-bridged Pt(III) dimer compound [Pt2(en)4I3]I3 (3) (en = ethylenediamine), which is prepared by iodine oxidation of [PtII(en)2] (1), has been successfully synthesized and characterized. This compound is stable and is obtained as diamond-shaped single crystals with a lustrous emerald-green color under reflected light and a red color under transmitted light. The two Pt centers are crystallographically equivalent and can be assigned as Pt(III). Density functional theory calculations reveal that the Pt(III) state is stabilized by the three-center four-electron (3c-4e) bonding in the Pt–I–Pt core (dz2–pz–dz2), in addition to the very strong antiferromagnetic state. This type of bonding stabilization does not appear in MX-Chains. The experimental polarized reflection spectra show the Pt(III) state character and are in agreement with the simulated spectra. The stabilization of Pt(III) through a 3c-4e bonding mechanism is novel; thus, this work provides new insight for stabilizing the unusual Pt(III) state.
Early Surgical Outcomes of Tetralogy of Fallot Patients Following Primary Intracardiac Repair at Uganda Heart Institute
Authors: Khainza Rebecca Esther , Oketcho Michael , Aliku Twalib , Namuyonga Judith , Ndagire Emma , Mwambu Tom , Muhoozi Rwakaryebe Mbagga , Obongnyinge Bernard , Tumwebaze Hilda , Mbabazi Nestor , Akech Teddy , Nakato Aisha , Killen Angelline , Ofumbi Geoffrey Oburu , Lwabi Peter , Omagino John , Lubega Sulaiman 
Published: January 2024

Abstract
Background
Tetralogy of Fallot (TOF) is the commonest form of cyanotic congenital heart disease (CHD) worldwide and accounts for 7% of CHD in Uganda. Without surgery, the natural history is nearly always fatal in the long term.
Surgery is recommended in infancy to avoid complications of chronic cyanosis and right sided heart failure. In developing countries like Uganda, surgery is usually delayed due several challenges.
Objective
This study was to determine the early surgical outcomes of TOF patients following primary intracardiac repair at Uganda Heart Institute (UHI) and identify factors associated with these surgical outcomes.
Methodology
This was a retrospective chart review of primary TOF repair patients at UHI between February 2012 and October 2022. The patient’s outcomes were reviewed from the time of surgery until 30 days in the post operative period.
Results
A total of 104 patients underwent primary TOF repair at UHI, records of 88 patients (84.6%) were available for review. Males accounted for 48.9% (n=43) of the cases. The median age at the time of operation was 4 years (interquartile range 5.46 years), age range of 9 months to 16years.
Children with phenotypic syndromes accounted for 5.7% (n=5), 2 with Down’s and 2 Noonan’s syndromes, followed by 1with Di George syndrome.
Early post operative outcomes included residual ventricular septal defects (VSDs) 39.8% (35/88), right ventricular (RV) dysfunction 37.5% (33/88), residual pulmonary regurgitation 30.7% (27/88), residual right ventricular outflow tract obstruction (RVOTO) 30.0% (27/88), pleural effusion 27.3% (24/88), arrhythmias 27.3% (24/88), left ventricular (LV) systolic dysfunction 10.2% (9/88).
Overall, 7 children (8%) died in the first 30 days and were all operated on after the age of one year.
At multivariate analysis mortality was associated significantly with prolonged mechanical ventilation time post procedure.
Conclusion
The commonest post operative outcomes were residual ventricular septal defects and RV failure. Our 30-day mortality following TOF repair was 8 %. Prolonged mechanical ventilation time was associated with mortality in this study.
GI-CO-FT confers microgravity response through Potential Regulatory Modules of Arabidopsis plants grown in Space
Authors: Zheng Huiqiong , junyan xie , Zhu Jiachen , Wang Lihua , Jiao Yuwei , Dou Yanhui , Zhao Zhongtian , Luo Boyu , Ha Meifan 
Published: January 2024

Abstract

Our previous studies suggested that FLOWERING LOCUS (FT) can serve as a central hub, integrating microgravity signals into the photoperiodic flowering pathway in Arabidopsis. However, the exact mechanisms remain unclear. In this study, we present findings from our recent experiments on the Chinese Space Station. Transcriptomic changes of space-grown plants, including wild-type (WT), gigantea (gi) mutant, CONSTANS overexpressing plants (35S:CO), and transgenic plants expressing FT with the green fluorescent protein gene controlled by a heat shock-inducible promoter (pHSP:GFP;pHSP:FT, FG), were compared with their ground-based controls. Analysis revealed a conserved transcriptional response signature primarily across the genotypes investigated. We pinpointed a new set of microgravity-responsive genes with a significant enrichment in flowering controlling pathways. In addition, this study highlighted bZIP, bHLH, BES1, and SBP family transcription factors, which are known integrators of hormone, light, and photoperiodic signals, as key mediators of the microgravity response in space.
Experimental study of surface residual stress and hardness of TiBw mesh reinforced titanium matrix composites in rotary ultrasonic grinding
Authors: Dong Guojun , Guo Zhiqing , Dai Yong , Lai Ruida , Liu Rongsong 
Published: January 2024

Abstract

TiBw mesh reinforced titanium matrix composites were investigated by rotary ultrasonic grinding experiments using nickel-based electroformed diamond grinding wheel and building a single diamond abrasive grain model and a 2D rotary ultrasonic grinding finite element model. Surface residual stress is obtained by simulation and verified by univariate experiments. Combined with nanoindentation experiments, the changes of residual stress and hardness were acquired. The results show that the reinforced phase fibers will be subjected to high mechanical stress which break the fibers and turn into chips with matrix material. The residual stress of TiBw-rich region is closer to the actual value due to the high elastic modulus and low residual strain of TiB. Residual compressive stress around -500MPa exists in the surface of workpiece under different process parameters. The residual stress decreases remarkably as the spindle speed increases. Meanwhile, the work hardening of workpieces changes similarly as the residual stress. The subsurface microstructure of titanium matrix composites after processing was tested by nanoindentation experiments and backscattered electron diffraction (EBSD). It was found that the surface hardness and dislocation density of the workpiece increased after machining, and the affected depth was about 10~15μm. XRD was further used to measure the surface phase of the workpiece under different processing parameters, the results show that the content of TiB reinforcements on the workpiece surface increases and the grain refinement decreases with the increase of spindle speed.
Effective Optical Zone Diameter, Decentration and High-Order Aberrations Following LIKE in Correcting Moderate to High Hyperopia
Authors: Zhang Bo , Chen Baihua , Wu Jiawei , Xiong Lu , Wang Zheng 
Published: January 2024

Abstract

Background
To compare the changes in effective optical zone (EOZ), centration offset and higher-order aberrations between femtosecond laser–assisted lenticule intrastromal keratoplasty (LIKE) and femtosecond-assisted laser in-situ keratomileusis (LASIK) for correcting hyperopia.
Methods
This is a retrospective unpaired nested case-control study reviewing data of series cases for hyperopia treatment in our department from 2018 to 2023. It mainly includes two surgeries and sets up two groups: LIKE and Hyperopic-LASIK group. Data primarily includes corrected minimum hyperopia ≥ + 1.00D and examination results within three months of follow-up at least.
Results
Cases included in LIKE group were mainly corrected for moderate-to-high- hyperopia (SEQ = + 6.14D), and in HLASIK group were corrected for low-to-moderate- hyperopia (SEQ = + 3.54D). The programmed optical zone diameter in LIKE was significantly smaller than postoperative result in HLASIK (6.27mm VS. 6.56mm). Through a novel measuring method of EOZ based on the ImageJ software, EOZ diameter obtained after LIKE procedure was significantly larger than that obtained after HLASIK (5.22mm VS. 4.61mm). The centration offset of the EOZ generated by LIKE was similar to that in HLASIK (0.27mm VS. 0.24mm). In LIKE, 95% of eyes had decentration within 0.5mm. The negative induction of corneal asphericity and spherical aberration after LIKE was significant, but even if it was correcting the higher hyperopia, that still has no significant difference with HLASIK.
Conclusion
Compared with HLASIK, LIKE has the potential to get larger EOZ and relative natural corneal morphology in correcting moderate to high hyperopia. And we propose a novel method for analyzing EOZ, which will help to improve the efficiency, accuracy, and convenience of graphical analysis.
Healthcost and Clinical Benefits of Rituximab in Steroid Sensitive Nephrotic Syndrome: Perspective From a Middle-Income Country (MyRITUX)
Authors: Tan Hai Liang , Yap Yok Chin , Bakar Karmila Abu , Eng Caroline Siew Yin 
Published: January 2024

Abstract
Background
The use of Rituximab for frequently relapsing (FRNS) and steroid dependent nephrotic syndrome (SDNS) is increasingly established. However, the use of Rituximab in resource-limited settings is constrained by its prohibitive cost.
Methods
This retrospective study included all children aged 1 to 18 years with FRNS and SDNS. The costs incurred when using either Rituximab or cyclosporine were calculated and compared. Clinical data retrieved from medical records.
Results
Twelve patients received rituximab while 11 patients were treated with cyclosporine. Annualised relapse rate reduced from 5.07 to 1.52 in the Rituximab and 1.01 in the cyclosporine group. Total healthcost was MYR 75,339.81 in the rituximab group and MYR83,098.25 in the cyclosporine group. Cost to reduce one relapse with Rituximab was MYR 1,104.95 /episode compared to Cyclosporine, MYR 1,500.42 /episode. We observed greater reduction in the amount of prednisolone use in the rituximab group (114.33mg/kg versus 99.91mg/kg in the cyclosporine group). Both demonstrated significant reduction in their body mass index z score. There were no infusion related reactions in the rituximab group and cyclosporin was also well tolerated.
Conclusion
This is the first study to compare the healthcare costs of using rituximab to be carried out in a middle income country. Findings suggest that in such setting, a single infusion of Rituximab as a steroid sparing agent among children with steroid sensitive nephrotic syndrome remains efficacious and feasible.
Influence of Circle of Willis Anatomy on the Safety of Carotid Endarterectomy under Regional Block
Authors: Ferreira Dantas Mageste , Dellaretti Marcos , Schumann Taianne Fiore , Gonçalves Vitor de Deus da Rocha Ribeiro , Silva Jéssica Aguilar 
Published: January 2024

Abstract
The success of carotid endarterectomy, an effective surgery in managing carotid stenosis, relies on reducing procedure complications. Therefore, prior understanding of the anatomy of the Circle of Willis is crucial to prevent complications.
Objective: To evaluate the anatomy of the Circle of Willis to determine the safety of endarterectomy in patients with carotid stenosis.
Methodology: A retrospective study in patients aged 18 or older with carotid stenosis indicating endarterectomy. Descriptive analysis, chi-square test, and Fisher's exact test were performed, adopting a significance level of p < 0.05.
Results: A total of 69 patients were evaluated, with an average age of 68.48 years; males represented 59.4% (n=41) of the sample, and 4.3% (n=3) did not tolerate the carotid artery cross-clamping test. Patients with patency of the anterior communicating artery and posterior communicating arteries were 18.2 times more likely to tolerate the cross-clamping test (p=0.026; 95% CI: 2.789-370.720).
Conclusion: The results of this study demonstrate that carotid endarterectomy is safe. In the evaluation of the Circle of Willis anatomy, it was evident that patients with an absent anterior communicating artery and absent posterior communicating arteries had a higher risk of carotid artery cross-clamping test intolerance, and the absence of the anterior communicating artery was associated with occurrences of complications in CEA. These findings emphasize the importance of assessing Circle of Willis anatomy preoperatively to determine the safety of the procedure.
Prediction of response to promising first-line chemotherapy in ovarian cancer patients with residual peritoneal tumors: Practical biomarkers and robust multiplex models
Authors: Kawabata-Iwakawa Reika , Iwasa Norihiro , Satoh Kenichi , Colinge Jacques , Shimada Muneaki , Takeuchi Satoshi , Fujiwara Hiroyuki , Eguchi Hidetaka , Oishi Tetsuro , Sugiyama Toru , Suzuki Mitsuaki , Hasegawa Kosei , Fujiwara Keiichi , Nishiyama Masahiko 
Published: January 2024

Abstract
Background: Platinum/taxane chemotherapy with debulking surgery stays the mainstay of the treatment in ovarian cancer patients with peritoneal metastasis. Recently its novel modality, intraperitoneal carboplatin with dose-dense paclitaxel (ddTCip), was shown to have greater therapeutic impact, but consequent recurrence or relapse still often occurs. Discovery of therapeutic response predictor to ddTCip therapy is eagerly awaited to improve current treatment strategy for disseminated ovarian cancer patients.
Methods: Using datasets in 76 participants in this study and 189 patients published in The Cancer Genome Atlas, we first validated a total of 75 previously suggested markers, sought out more active biomarkers through the association analyses of genome-wide transcriptome and genotyping analyses with progression-free survival (PFS)and adverse events, and then developed multiplex statistical prediction models for PFS and toxicity by mainly using multiple regression analysis and the classification and regression tree (CART) algorithm.
Results: The association analyses revealed that SPINK1 expression could be a potent biomarker of ddTCip efficacy, while ABCB1 rs1045642 and ERCC1rs11615 would be a predictor of hematologic toxicity and peripheral neuropathy, respectively. Multiple regression analyses and CART algorithm finally provided a potent efficacy prediction model using 5 gene expression data and robust multiplex prediction models for adverse events: CART models using a total of 4 genotype combinations and multiple regression models using 15 polymorphisms on 12 genes.
Conclusion: Our proposed biomarkers and multiplex models composed here would work well in the response prediction of ddTCip therapy, which might contribute to realize optimal selection of the key therapy.
Identifying immune cell infiltration and diagnostic biomarkers for nasopharyngeal carcinoma through bioinformatic analysis
Authors: zhao yahui , Qiu Zhaofeng , ye shengnan 
Published: January 2024

Abstract
Backgrounds: Explore the genomic and signaling pathways contributing to nasopharyngeal carcinoma, a prevalent and multifactorial cancer involving environmental, genetic, and EB virus factors. This study aims to identify potential genes associated with nasopharyngeal cancer and examine their relationship with immune cell infiltration.
Methods: The Gene Expression Omnibus (GEO) database provided three sets of nasopharyngeal cancer data: two for training and one for validation. To identify candidate genes, a Protein-Protein Interaction (PPI) network was constructed using a string database and two machine learning algorithms: the Least Absolute Selection and Shrinkage Operator (LASSO) and the Supporting Vector Machine Resource Elimination (SVM-RFE). The external validation dataset assessed the proposed levels of expression of biomarkers and the diagnostic value of the test to evaluate its effectiveness. Receiver Operating Characteristic (ROC) curves were used to measure diagnostic performance, convolutional techniques in CIBERSORT were applied for immune cell infiltration analysis, and correlation analysis was conducted using the training dataset.
Results: The GEO database provided GSE12452 and GSE13597 datasets. The limma package filtered 58 differential genes, including 13 upregulated and 35 downregulated genes, which were visualized using volcano maps, heat maps, and PCA. Enrichment analysis results indicated a significant association between inflammation and disease. The Lasso and SVM algorithms were applied to screen 9 and 37 differential genes, respectively. Overlapping genes associated with nasopharyngeal cancer include ATP12A, LAMB1, RAD51AP1, CXCL11, BINSM1, PTGS2, and SAA1. Their diagnostic significance was confirmed using the operational characteristic Receptor of the validation group, and they were found to be highly connected to the degree of immune cell infiltration.
Conclusions: These seven genes are considered promising biomarkers for diagnosing nasopharyngeal cancer, paving the way for future research on the immunological mechanisms and therapy of nasopharyngeal carcinoma.
Fredholm Nature of Orbital Frame Operators in Hilbert Spaces
Authors: Rezaei Hamid , Saeedi Zahra 
Published: January 2024

Abstract
A linear operator T on a Hilbert space H is said to be orbital frame if there exists a vector x ∈ H such that orb(T, f) constitutes a frame. This paper presents a novel examination of frames in the context of Hilbert space H, showing that orbital frame operators must be Fredholm. In particular, if an orbital frame operator T either has a dense range or is one-to-one then it is an invertible.
MSC2020 Classification: 46B15 , 47B02
Seroprevalence of Hepatitis B Infection Among Blood Donors in the Western Zone of Tanzania
Authors: Marira Gadiel J. , Kimaro Esther G. , Sauli Elingarami 
Published: January 2024

Abstract

Background
In the western zone of Tanzania, there is limited information for the prevalence of hepatitis B infection. In this study, we analyzed the dataset of blood donors to determine seroprevalence and socio-demographic factors related to Hepatitis B Virus infection among blood donors in the western regions of Tanzania.
Material and Methods
The study was a cross-sectional retrospective hospital-based. Data were retrieved from blood donor dataset given at the Zonal Blood Transfusion Center. Information analyzed from the dataset includes reported Transfusion Transmissible Infections (TTIs) including Hepatitis B, donor demographics, donor status, donor type, donation place, and the year of donation. This study focused on five years period from January 2018 to December 2022. The seroprevalence rates of hepatitis B surface antigen (HBsAg) were determined, and the univariate and multivariate analysis were conducted to determine association between infection and demographic risk factors under STATA version 15.1.
Results
A total of 9604 retrospective blood donors were screened. Majority (93.3%) were men, and most were under 45 years (89.6%). The overall, seroprevalence for HBsAg was 6.9% (661) in this study, with Katavi (7.8%) being relatively high in the study area. The highest HBsAg seroprevalence of 8.2%, was found to be in age group range of 35 to 44 years. In addition, Polygamist 9.5%, and drivers at 17.1% were shown to have relatively high seroprevalence in this case. Using multivariate analysis, the results indicate blood donors who were drivers (OR 5.44, 95% CI; 2.43 12.20, p < 0.001), and the first-time donors (OR 5.19, 95% CI 2.56 = 10.52, P 4 < 0.001), were highly associated with an increased chance of hepatitis B infection.
Conclusion
The findings demonstrate that; there is a high seroprevalence of HBV in western regions. These findings bring to the attention of more advocacy for HBV immunization for all persons at high risk, as it is the most effective way to prevent HBV infection.