bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence of extraintestinal manifestations in Inflammatory Bowel Disease
Authors: Madej Aleksandra , Senat Hanna , Grabowska Patrycja , Bolla Patrycja , Senat Aleksandra , Marczyńska Zuzanna 
Published: February 2024

INTRODUCTION: The term inflammatory bowel disease (IBD) refers to a chronic inflammatory disease of the gastrointestinal tract of unclear pathogenesis. IBD consists of ulcerative colitis (UC) and Crohn's disease (CD). The two most common manifestations of the disorder, both have a chronic course with episodes of acute activity. Their underlying pathogenesis and symptoms, however, are quite distinct. IBD has a multiple factor etiology involving genetics, immunological dysregulation and dysbiosis of the intestinal microbiome. The resulting chronic inflammation of the entire body is the cause of the symptoms and signs of the condition. Extraintestinal manifestations (EIM) occur in 5% to 50% of IBD patients over the course of their lifetime.
PURPOSE: The aim of the study is to present the current state of knowledge about the prevalence of extraintestinal manifestations in Inflammatory Bowel Disease.
MATERIALS AND METHOD: The available literature in PubMed was reviewed to write the article, using the keywords ,,inflammatory bowel disease”, ,,Crohn’s disease”, ,, ulcerative colitis”, ,,extraintestinal manifestations IBD”.
CONCLUSION: Extraintestinal manifestations are evidence that IBD is not only confined to the intestine, these may involve many different organs other than the gut and may be more devastating than the IBD. Screening for EIM in these patients and prompt adequate treatment are essential. To adequately manage EIM and improve the quality of life of our patients, appropriate treatment regimens and therapies are required in a multidisciplinary team approach. Due to the lack of available dedicated diagnostic biomarkers for EIM, consideration of concomitant extraintestinal conditions in patients with inflammatory bowel disease might help in the selection and management of them. Clinicians caring for patients with IBD must be aware of these various systemic manifestations, as failure to diagnose and treat them early can result in significant morbidity.
Exploring Future Horizons in Osteoarthritis Relief: Unveiling the Potential of Slow-Acting Drugs and Innovative Medications
Authors: Sokołowska Katarzyna , Bereza Dawid , Kulak Maria , Moreau Igor , Polańska Paulina , Lang Miriam , Woch Barbara 
Published: February 2024

Introduction:
The existing treatment options for osteoarthritis (OA) fall short of addressing the significant challenges this disease imposes on patients in today's society. It markedly diminishes the quality of life of those affected and is one of the leading causes of disability. While conventional pharmacological interventions such as non-steroidal anti-inflammatory drugs (NSAIDs) and opioids effectively address pain, they are not intended to halt disease progression and are associated with potential health risks. Symptomatic Slow-Acting Drugs for Osteoarthritis (SYSADOA) and innovative medications, rooted in our expanding understanding of OA pathogenesis, offer promising prospects for discovering improved treatment modalities.

State of knowledge:
The evolving understanding of OA's etiology highlights the necessity for tailored treatments that consider distinct disease phenotypes. This review critically examines SYSADOA, specifically focusing on chondroitin sulfate, glucosamine, and avocado-soybean unsaponifiables, as agents designed to address the underlying pathology of OA. Chondroitin sulfate demonstrates potential disease-modifying effects, however with conflicting study results that underscore the extent of its efficacy. Glucosamine exhibits varying disease-modifying effects, with short-term trials demonstrating more promising outcomes in pain reduction. Avocado-soybean unsaponifiables show promise in alleviating knee OA pain, yet their impact on hip OA symptoms remains inconclusive. The review extends its scope to novel drugs with potential disease-modifying effects, exploring proteinase inhibitors, fibroblast growth factors, Wnt-signaling pathway inhibitors, senolytic agents, anti-nerve growth factor agents, and transforming growth factor-β.

Conclusions:
Although preliminary studies indicate potential for certain novel agents, challenges and adverse effects necessitate further investigation through rigorous, high-quality research.
Use of horse riding in chronic pain therapy
Authors: Mazur Sylwia , Mazur Agata , Madera Magdalena , Bizan Aleksy , Nagórska Emilia , Marcinkowski Krzysztof , Strus Karolina , Kublińska Aleksandra , Zdunek Roksana , Dąbrowska Natalia 
Published: February 2024

Introduction and purpose: Chronic pain is a struggle itself and also a symptom in many common conditions. Its complexity requires diverse treatment methods including some that might seem unconventional, for example, horse riding. This study gathers information about the use of equine assisted therapy in pain relief.
Brief description of the state of knowledge: Hippotherapy is known as an important part of care for patients with cerebral palsy, attention deficit and autism. The rhythmical, multidimensional movements of the horse are transmitted to the rider’s pelvis and help in strengthening and stretching the muscles which result in better posture stabilization and balance. The positive effects of equine assisted therapy are not limited to only physical ones but positive social, cognitive and psychological effects can be observed as well. In order to lower the cost and time of the therapy, horse riding simulators were invented. So far, horse riding has been tested as a pain relief tool in entities like nonspecific low back pain, multiple sclerosis and arthritis.
Summary: Horse riding sessions had beneficial effects on pain levels among patients with nonspecific back pain and arthritis. There is a need to conduct further research in order to properly compare the use of real horses versus horse simulators. Hippotherapy was well perceived by different patient groups so maybe it has the potential to be an important part of pain management in various conditions.
Basal cell carcinoma - the most common form of skin cancer. Methods of treatment
Authors: Iwańczuk Paweł 
Published: February 2024

Introduction: Basal cell carcinoma is the most common form of skin cancer. The lifetime risk is estimated as 33% to 39% in white men and 23% to 28% in white women. Because of that it is a very crucial disease for public health. In this article will be described main pathways of treatment which are especially recommended and are the most wide used for different types of basal cell carcinoma. Main division of interventions type used in treatment of basal cell carcinoma are surgical (physical) and non-surgical (medical). Surgical (physical) includes surgical standard excision, Mohs micrographic surgery, curettage and cautery, cryosurgery and laser therapy (ablative lasers, pulsed dye lasers). Non-surgical (medical) includes radiotherapy, topical imiquimod, topical 5- fluorouracil, photodynamic therapy, intralesional interferon.

Aim of study: Literature review of the most recommended treatment of basal cell carcinoma.

State of knowledge: In this publication will be desribed a current state of knowledge about basic and the most crucial basal cell carcinoma treatment.

Conclusion: Because of incidence rate of basal cell carcinoma which is very high- there are many reports about treatment of this disease. Treatment of this disease, especially among low risk patients, is very effective.
A Comprehensive Review on the Latest Insights into Cold Therapies and Their Impact on the Human Body, with a Focus on Neurophysiological Responses
Authors: Stachyrak Karol , Gregułą Anna , Mazur Bartosz , Mika Dawid , Kłos Aleksandra , Turek Kamila , Lambach Maciej , Pawlicki Mateusz , Mazurek Aleksandra , Wilanowska Wiktoria 
Published: February 2024

Introduction
In contemporary medicine, increasing attention is being devoted to alternative forms of therapy. Immersing oneself in cold water, cryotherapy, or cold showers are practices that have long sparked interest due to their potential health benefits.
Aim of the study
The aim of this comprehensive review is to analyze the impact of cold exposure on the human body, with particular emphasis on its effects on the nervous system. Through the synthesis of available research, the paper seeks to identify health benefits and areas requiring further investigation in the context of various cold application practices.
Materials and methods
An analysis of scientific articles available in the Pubmed and Google Scholar databases was conducted. Publications from recent years that most relevantly addressed the discussed topic were utilized for this study. The search process involved the use of the following keywords: “cold,” “cold showering,” “cold water,” “cryotherapy.”
Results
The results of the literature review unequivocally indicate a positive, multifaceted impact of cold on the human body, particularly with an emphasis on the nervous system. Significant therapeutic effects observed in various fields suggest that the application of cold may be a promising alternative in promoting health and treating numerous medical conditions.
Summary
The focused literature review on the impact of cold on the human body, especially the nervous system, presents various therapies such as cryotherapy or cold water immersion, emphasizing their beneficial effects on the nervous, cardiovascular, endocrine, lymphatic, musculoskeletal, and joint systems. However, despite the observed benefits, further research is needed to gain a more detailed understanding of the mechanisms of action and to ensure the safety of these practices.
Higher and Sustained Cell-Mediated Immune Responses after Three Doses of mRNA COVID-19 Vaccine In Patients with Inflammatory Bowel Disease on Anti-TNF Therapy
Authors: Caldera Freddy , Rolak Stacey , Farraye Francis A. , Necela Brian M. , Cogen Davitte , Zona Emily E. , Schell Trevor L. , Ramirez Oscar Ramirez , Almasry Mazen , Chun Kelly , Hayney Mary S. , Knutson Keith L. 
Published: February 2024

Introduction:
Studies suggest that the generation of durable T cell immunity following COVID-19 vaccination protects against severe disease. The aim of this study was to measure cell mediated immune response (CMIR) one to two months and six months after a third dose of a COVID-19 mRNA vaccine.

Methods:
This prospective study (HERCULES) evaluated CMIR at 28–65 days (t1) after dose 2, 28–65 days (t2) (n=183) and six months (+/-45 days) (t3) (n=167) after a third dose of an mRNA COVID-19 vaccine. A small cohort had blood available 28-65 days (t4) (n=55) after a fourth dose. Primary outcomes were CMIR at (t2) and (t3). Secondary outcomes included the effect of immunosuppressing IBD medications on CMIR and response at (t4).

Results:
All patients had measurable CMIR at all time points. CMIR increased at t2 compared to t1 (median 1467 responding cells per million (interquartile range (IQR) 410-5971) vs 313 (94-960) p< 0.001). There was no significant waning when comparing t2 vs t3 or significant boosting at t4. Those on anti-TNF monotherapy had a higher CMIR compared to those not on this therapy at t2 (4132 ( IQR 1136-8795) vs. 869 (IQR 343-3221) p <0.001) and t3 (2843 (IQR 596-6459) vs 654 (IQR 143-2067) p<0.001). In univariable analysis, anti-TNF monotherapy was associated with a higher CMIR at t2 (p< 0.001) and t3 (p< 0.001) and confirmed in a multivariable model (p< 0.001).

Conclusion:
A third dose of a COVID-19 vaccine boosts CMIR, and the response is sustained in patients with IBD.
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Authors: Eggers Kai M. , Batra Gorav , Lindahl Bertil , Ghukasyan Lakic Tatevik , Lindbäck Johan , Budaj Andrzej , Cornel Jan H. , Giannitsis Evangelos , Katus Hugo A. , Storey Robert F. , Becker Richard C. , Siegbahn Agneta , Wallentin Lars 
Published: February 2024

Abstract

Objectives
Biomarker concentrations and their changes during acute coronary syndrome (ACS) provide clinically useful information on pathophysiological processes, e.g. myocardial necrosis, hemodynamic stress and inflammation. However, current evidence on temporal biomarker patterns early during ACS is limited, and studies investigating multiple biomarkers are lacking.

Methods
We measured concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI), NT-terminal pro-B-type natriuretic peptide, C-reactive protein, and growth-differentiation factor-15 (GDF-15) in plasma samples obtained at randomization in ACS patients from the PLATelet inhibition and patient Outcomes (PLATO) trial. Linear regressions with interaction analyses were used to investigate the associations of biomarker concentrations with the time from symptom onset and to model temporal biomarker concentration patterns.

Results
The study population consisted of 16,944 patients (median age 62 years; 71.3 % males) with 6,853 (40.3 %) having ST-elevation myocardial infarction (STEMI) and 10,141 (59.7 %) having non-ST-elevation ACS (NSTE-ACS). Concentrations of all biomarkers were associated with time from symptom onset (pinteraction<0.001), apart for GDF-15 (pinteraction=0.092). Concentration increases were more pronounced in STEMI compared to NSTE-ACS. Temporal biomarker patterns for hs-cTnT and hs-cTnI were different depending on sex whereas biomarker patterns for the other biomarkers were similar in cohorts defined by age and sex.

Conclusions
Temporal concentration patterns differ for various biomarkers early during ACS, reflecting the variability in the activation and duration of different pathophysiological processes, and the amount of injured myocardium. Our data emphasize that the time elapsed from symptom onset should be considered for the interpretation of biomarker results in ACS.
Gender Differences in the use of Social Capital for Entrepreneurial Activity Within Contexts of Poverty
Authors: Proaño Sánchez Fernando X. , Bojica Ana M. 
Published: February 2024

Abstract
Previous research has pointed to differences in the use of social capital between male and female entrepreneurs that may explain, in part, the different outcomes they obtain. Adopting a gender perspective, this study analyses whether these differences depend on the contextual configurations in which their businesses operate, specifically the degree of hostility of the context and their household structure. Thirty male and female entrepreneurs who set up their businesses in poor neighbourhoods in and around the city of Guayaquil (Ecuador) were interviewed. Data was analysed using content analysis and comparative qualitative fuzzy set analysis. The results show that women rely on bridging and bonding social capital for favourable entrepreneurial outcomes, while men rely mainly on bonding social capital, with the structure of the household being one of the influences that condition whether or not they go outside their immediate environment to mobilise resources. This work contributes to a better understanding of how the relational behaviour of male and female entrepreneurs is conditioned by gender and context. These results differ from those obtained in previous research focusing more on developed countries and suggest that gender differences in social capital are at least partly explained by the contextual configurations in which entrepreneurs find themselves, and especially by the needs and agency space available to them, rather than by the faithful reproduction of gender roles and the behavioural patterns derived from them.
Tunable hyperbolic polaritons with plasmonic phase-change material In3SbTe2
Authors: Lu Dunzhu , Zeng Ying , Yan Qizhi , Chen Qiyu , Ma Weiliang , Luo Xiao , Xu Ming , Yang Xiaosheng , Li Peining 
Published: February 2024

Abstract
Hyperbolic polaritons that originate from the extreme optical anisotropy in van der Waals (vdW) crystals have gained much attention for their potential in controlling nanolight. For practical use, there has been a strong interest to develop various manipulation strategies to customize the propagation of hyperbolic polaritons on a deeply sub-diffractional scale. In this regard, phase-change materials (PCMs) that possess two phases with different refractive indices offer suitably a tunable dielectric environment. Here, we report on the tuning of hyperbolic phonon polaritons in natural vdW crystals, hexagonal boron nitride (hBN), and alpha-phase molybdenum trioxide (α-MoO3), using the plasmonic phase-change material In3SbTe2 (IST). Unlike conventional PCMs whose both phases are dielectric, IST features a metallic crystalline phase that is stable at room temperature. The coupling between polaritons with their mirror charges in the underneath crystalline IST triggers an even stronger field confinement for polaritons. Moreover, benefited from the metallicity of laser-writable crystalline IST, we show an all-optical material platform in which crystalline IST boundaries efficiently excite and focus hyperbolic phonon polaritons in α-MoO3. Our experiments highlight the possibility to obtain new degrees of freedom in polariton engineering with plasmonic PCMs, thereby expanding the toolkit of tunable nanophotonics with flexible, on-demand fabrication and reconfiguration capabilities.
Climate resilience plastic degradation potential of Pseudomonas putida isolated from the soil of plastic waste dumping sites to reduce GHG emissions
Authors: Majeed Hammad , Iftikhar Tehreema , Abbas Qamar 
Published: February 2024

Abstract
Climate change is a universal issue and plastic trash is the major cause of global warming. The present study was specifically designed to address the escalating plastic waste problem, the biodegradation of low-density polyethylene (LDPE) bags was investigated over an 8-week period using liquid culture approach. Bacterial strain (Pseudomonas putida) capable of degrading LDPE was isolated from common plastic garbage dumping sites. The strain was identified after sequencing analysis, as P. putida was evaluated for its effectiveness in degrading LDPE. Various analytical techniques, including weight loss, SEM, FTIR and GC-MS were employed to assess the degradation process. Results revealed that bacterial strain achieved 0.0776 % degradation. SEM and FTIR confirmed surface and chemical changes, while GC MS identified degradation by products in comparison to the control (where no bacteria was used).
Removal of chemicals from effluent using photobioreactor technology to improve environmental and health impacts
Authors: Karuppannan Parimala Gandhi , Paramasivam Selvakumar , Mariappan Petchiammal , Shunmugam Sivagami , Richard Paul Samuel Jabez 
Published: February 2024

Abstract
The treatment of industrial waste water using cyanobacteria in photobioreactor for the removal of sulphide, COD and phenol. The microorganisms were collected from the effluent treatment plant of a petroleum refinery and a biofilm was developed in nutrient medium. The reactor was fed with cyanobacteria. After biofilm formation and acclimatization, the same procedure was followed for 16 days in a rectangular tray type photo bioreactor for the treatment of industrial waste water. From continuous mode of operation, it was found that the phototrophic microorganisms can degrade the pollutants present in industrial waste water. The removal efficiency of hardness 75 %, sulphide 95.8 %, COD 98.7 %, phenol 99.9 % and nitrate 83.7 % was studied. The present works shows that it is feasible to use cyanobacteria in a photo bioreactor for the treatment of industrial waste water.
The COVID-19 lockdown experience suggests that restricting the supply of gambling can reduce gambling problems: An Australian prospective study
Authors: Hing Nerilee , Russell Alex M.T. , Rawat Vijay , Bryden Gabrielle M. , Browne Matthew , Rockloff Matthew , Thorne Hannah B. , Newall Philip , Dowling Nicki A. , Merkouris Stephanie S. , Stevens Matthew 
Published: February 2024

AbstractBackground and aimsCOVID-19 lockdowns limited access to gambling but simultaneously elevated psychosocial stressors. This study assessed the relative effects of these changes on gambling risk status during and after the Australian COVID-19 lockdown from late-March to late-May 2020.MethodsThe study administered three surveys to people who had gambled within the past year at T1. Wave 1 asked about before (T1, N = 2,125) and during lockdown (T2, N = 2,125). Subsequent surveys focused on one year (T3; N = 649) and two years after lockdown (T4, N = 458). The dependent variable was changes in reporting any problem gambling symptoms (PGSI 0 vs 1+). Bivariate analyses and multinomial logistic regression tested for significant associations with: demographics, psychosocial stressors (perceived stress, psychological distress, loneliness, health anxiety about COVID, financial hardship, stressful life events), gambling participation and gambling frequency.ResultsGambling participation and at-risk gambling decreased between T1 and T2, increased at T3, with little further change at T4. When gambling availability was curtailed, decreased gambling frequency on EGMs, casino games, sports betting or race betting, and lower psychosocial stress, were associated with transitions from at-risk to non-problem gambling. When gambling availability resumed, increased EGM gambling frequency, decreased online gambling frequency, and higher psychosocial stress were associated with transitions from non-problem to at-risk gambling.Discussion and conclusionsGambling availability appears a stronger influence on gambling problems, at the population level, than psychosocial risk factors. Reducing the supply of high-risk gambling products, particularly EGMs, is likely to reduce gambling harm.
Aurelia Medina: muebles mínimos de impacto máximo
Authors: Aguilar Alejandre María 
Published: February 2024

Aurelia Medina es una diseñadora andaluza contemporánea con una producción muy polifacética que abarca territorios tan diversos como el estampado textil, el diseño de complementos de moda o el diseño de interiores. Este artículo ahonda en sus trabajos en el ámbito del mobiliario y el objeto cotidiano recorriendo sus obras principales así como sus bases conceptuales y estrategia proyectual. Para ello, y primeramente, se realiza una aproximación biográfica a su figura a la vez que se contextualiza el trabajo de investigación bajo un enfoque de género. Con ello se pretende contribuir a la construcción de un legado patrimonial andaluz en materia de diseño que integre a sus figuras femeninas.