bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Density-Lipoprotein Cholesterol and Mortality Outcomes Among Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Authors: Zhou Zhen , Tonkin Andrew M , Curtis Andrea J , Murray Anne , Zhu Chao , Reid Christopher M , Williamson Jeff D , Ryan Joanne , McNeil John J , Beilin Lawrence J , Ernst Michael E , Stocks Nigel , Lacaze Paul , Shah Raj C , Woods Robyn L , Wolfe Rory , Gall Seana , Zoungas Sophia , Orchard Suzanne G , Nelson Mark R 
Published: December 2023

Abstract

Background
The prognostic implication of cholesterol levels in older adults remains uncertain. This study aimed to examine the relationship between low-density-lipoprotein cholesterol (LDL-c) and mortality outcomes in older individuals.

Methods
This post hoc analysis examined the associations of LDL-c levels with mortality risks from all-cause, cardiovascular disease (CVD), cancer, and combined non-CVD/noncancer conditions in a cohort of individuals aged ≥65 years from the ASPirin in Reducing Events in the Elderly trial (NCT01038583). At baseline, participants had no diagnosed dementia, physical disability, or CVD, and were not taking lipid-lowering agents. Outcome analyses were performed using multivariable Cox models.

Results
We analyzed 12 334 participants (mean age: 75.2 years). Over a median 7-year follow-up, 1 250 died. Restricted cubic splines found a U-shaped relation for LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVE mortality (nadir: 3.3–3.4 mmol/L); the risk of CVD mortality was similar at LDL-c below 3.3 mmol/L and increased above 3.3 mmol/L. Similar trends were observed in analyses modeling LDL-c by quartiles. When modeling LDL-c as a continuous variable, the risk of all-cause mortality, cancer mortality, and noncancer/non-CVD mortality was decreased by 9%, 16%, and 18%, respectively, per 1-mmol/L higher LDL-c, and the risk of CVD mortality was increased by 19% per 1-mmol/L higher LDL-c. Reduced all-cause and non-CVD/noncancer mortality risks were only significant in males but not females (pinteraction &lt; .05).

Conclusions
There were U-shaped relationships between LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVD mortality in healthy older adults. Higher LDL-c levels were associated with an increased risk of CVD mortality. Future studies are warranted to confirm our results.
Association Between Trajectory of Socioeconomic Position and Regional Brain Volumes Related to Dementia: Results From the NEIGE Study
Authors: Morita Ayako , Fujiwara Takeo , Murayama Hiroshi , Machida Masaki , Inoue Shigeru , Shobugawa Yugo 
Published: December 2023

Abstract

Background
Low socioeconomic position (SEP) has been linked to an increased risk of dementia. However, little is known about the association between SEP trajectory and regional brain volumes related to dementia.

Methods
A random sample of community-dwelling older adults (n = 428, age = 73.1 ± 5.5) living in Tokamachi City (Niigata Prefecture, Japan) without medical histories of dementia, Parkinson’s disease, and depression who underwent automated assessment of brain volumes on magnetic resonance imaging and responded to a self-administered questionnaire survey in 2017. We measured SEP in childhood (household SEP at age 15), young adulthood (education), mid-adulthood (the longest occupation), and late adulthood (current wealth), and further performed group-based trajectory analysis to identify lifetime trajectory patterns on SEP. Multivariate regression models were employed to investigate the association between SEP trajectories and 4 regional brain volumes related to the development of Alzheimer’s disease (ie, entorhinal cortex, hippocampus, amygdala, and the parahippocampus), the most common type of dementia.

Results
We found 3 distinct SEP trajectories (stable middle class [68%], downward [23%], and upward [9%]). Compared to those who experienced stable middle class, older adults who experienced the upward SEP mobility had significantly larger hippocampus (β: 213.2, 95% confidence interval: 14.7, 411.8). On the other hand, older adults who experienced downward SEP mobility showed no significant differences in any of the 4 brain structural volumes.

Conclusions
Our findings indicate that upward life-course SEP mobility is associated with larger volumes of hippocampus in old age. SEP trajectory may offer us a useful lens to enhance our understanding of the etiology of dementia.
Prescription drug monitoring program use by opioid prescribers: a cross-sectional study
Authors: Sacarny Adam , Williamson Ian , Merrick Weston , Avilova Tatyana , Jacobson Mireille 
Published: December 2023

Abstract
Clinician use of prescription drug monitoring programs (PDMPs) has been linked to better patient outcomes, but state requirements to use PDMPs are unevenly enforced. We assessed PDMP use in Minnesota, which requires opioid prescribers to hold accounts and, in most cases, search the PDMP before prescribing, but where enforcement authority is limited. Using 2023 PDMP data, we found that 4 in 10 opioid prescribers did not search and 2 in 10 did not hold an account. PDMP use was strongly associated with prescribing volume, but even among the top decile of opioid prescribers, 8% never searched the PDMP. Thirty-two percent of opioid fills came from clinicians who did not search the PDMP. Failures to use the PDMP may be driven by a lack of information about state requirements, beliefs that these requirements are not enforced, and the costs of accessing the PDMP relative to the benefits. These results highlight the potential for policy makers to promote safer and better-informed prescribing of opioids and other drugs by addressing the forces that have limited PDMP use so far.
Geographic variations in driving time to US mental health care, digital access to technology, and household crowdedness
Authors: Negaro Sophia N D , Hantman Rachel M , Probst Janice C , Crouch Elizabeth L , Odahowski Cassie L , Andrews Christina M , Hung Peiyin 
Published: December 2023

Abstract
Rural residents face significant barriers in accessing mental health care, particularly as the demand for such services grows. Telemedicine has been proposed as an answer to rural gaps, but this service requires both access to appropriate technology and private space in the home to be useful. Our study documented longer travel time to mental health facilities in rural areas and greater barriers to digital devices for telemedicine access in those same areas. However, urban areas demonstrated greater household crowdedness than rural noncore areas when looking at private space within the home. Across ZIP Code Tabulation Areas located more than an estimated 30 minutes from the nearest outpatient care, 675 950 (13.1%) rural households vs 329 950 (6.4%) urban households had no broadband internet. The current Affordable Connectivity Program should target mental health–underserved communities, especially in rural America, where the scarcity of digital access compounds travel burdens to mental health care.
MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice
Authors: Zheng Ya-Bin , Sheng Xiao-Ming , Jin Xiang , Guan Wei 
Published: December 2023

Abstract

Background
Depression is a neuropsychiatric disease with a high disability rate and mainly caused by the chronic stress or genetic factors. There is increasing evidence that microRNAs (miRNAs) play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far.

Methods
We first established a chronic social defeat stress (CSDS) mice model of depression, and depression-like behaviors of mice were evaluated by a series of behavioral tests. Next, we detected several abundantly expressive miRNAs suggested in previous reports to be involved in depression and found miR-182-5p was selected as a candidate for analysis in the hippocampus. Then western blotting and immunofluorescence were used together to examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated chronic stress–induced decrease in hippocampal Akt/GSK3β/cAMP-response element binding protein (CREB) signaling pathway and increase in neurogenesis impairment and neuroinflammation. Furthermore, CREB inhibitor was adopted to examine if blockade of Akt/GSK3β/CREB signaling pathway abolished the antidepressant actions of AAV-siR-182-5p in mice.

Results
Knockdown of miR-182-5p alleviated depression-like behaviors and impaired neurogenesis of CSDS-induced mice. Intriguingly, the usage of agomiR-182-5p produced significant increases in immobility times and aggravated neuronal neurogenesis damage of mice. More importantly, it suggested that 666-15 blocked the reversal effects of AAV-siR-182-5p on the CSDS-induced depressive-like behaviors in behavioral testing and neuronal neurogenesis within hippocampus of mice.

Conclusions
These findings indicated that hippocampal miR-182-5p/Akt/GSK3β/CREB signaling pathway participated in the pathogenesis of depression, and it might give more opportunities for new drug developments based on the miRNA target in the clinic.
Evaluation of prescription review and feedback policy on rational antibiotic use in primary healthcare settings in Beijing, China: a qualitative study using the Theoretical Domains Framework and the behaviour change wheel
Authors: Wushouer Haishaerjiang , Du Kexin , Chen Shicai , Li Huangqianyu , Zhang Wanmeng , Yang Yaoyao , Hu Lin , Zhou Yue , Sun Hui , Zheng Bo , Guan Xiaodong , Shi Luwen 
Published: December 2023

Abstract

Objectives
To decelerate antibiotic resistance driven by inappropriate antibiotic prescribing, a prescription review and feedback (PRF) policy is implemented in primary healthcare institutions (PHIs) in Beijing, China. However, evaluation of PRF implementation in PHIs is scarce. This study aims to systematically identify the barriers and facilitators of PRF policy implementation to provide evidence for antimicrobial stewardship.

Methods
We conducted key informant interviews with 40 stakeholders engaged in the implementation of PRF in Beijing, including physicians, pharmacists and administrators. Interviews were audio recorded and transcribed verbatim. We coded the interview transcripts and mapped informant views to domains of the Theoretical Domains Framework. We then used a behaviour change wheel to suggest possible behavioural interventions.

Results
Procedural knowledge (Knowledge) and skills (Skill) of PRF were possessed by stakeholders. They felt responsible to promote the appropriate use of antibiotics (Social/professional role and identity) and believed that PRF could help to change inappropriate provider behaviours (Behavioural regulation) in prescribing antibiotics (Beliefs about consequences) under increased intention on antibiotic use (Stages of change). Moreover, informants called for a more unified review standard to enhance PRF implementation (Goals). Frequently identified barriers to PRF included inadequate capacity (Skill), using punishment mechanism (Behaviour regulation), reaching consistently lower antibiotic prescription rates (Goals), lack of resources (Environmental context and resources) and perceived pressure coming from patients (Social influences).

Conclusions
Stakeholders believed that PRF implementation promoted the rational use of antibiotics at PHIs in Beijing. Still, PRF was hampered by inconsistencies in review process and resources needed for PRF implementation.
Methods for studying medication safety following electronic health record implementation in acute care: a scoping review
Authors: Pereira Nichole , Duff Jonathan P , Hayward Tracy , Kherani Tamizan , Moniz Nadine , Champigny Chrystale , Carson-Stevens Andrew , Bowie Paul , Egan Rylan 
Published: December 2023

Abstract

Objectives
The objective of this scoping review is to map methods used to study medication safety following electronic health record (EHR) implementation. Patterns and methodological gaps can provide insight for future research design.

Materials and methods
We used the Joanna Briggs Institute scoping review methodology and a custom data extraction table to summarize the following data: (1) study demographics (year, country, setting); (2) study design, study period, data sources, and measures; (3) analysis strategy; (4) identified limitations or recommendations; (5) quality appraisal; and (6) if a Safety-I or Safety-II perspective was employed.

Results
We screened 5879 articles. One hundred and fifteen articles met our inclusion criteria and were assessed for eligibility by full-text review. Twenty-seven articles were eligible for extraction.

Discussion and conclusion
We found little consistency in how medication safety following EHR implementation was studied. Three study designs, 7 study settings, and 10 data sources were used across 27 articles. None of the articles shared the same combination of design, data sources, study periods, and research settings. Outcome measures were neither defined nor measured consistently. It may be difficult for researchers to aggregate and synthesize medication safety findings following EHR implementation research. All studies but one used a Safety-I perspective to study medication safety. We offer a conceptual model to support a more consistent approach to studying medication safety following EHR implementation.
Digital Breast Tomosynthesis With Synthetic Mammography: Are We Missing Calcifications That Matter?
Authors: Nguyen Adrien , Mirchandani Anicia , Joseph Sumita , Mapkar Zaiba , Singh Evita 
Published: December 2023

Abstract

Objective
To determine whether there are differences in the biopsy outcomes for suspicious calcifications detected with screening mammography using the digital breast tomosynthesis and synthetic 2D (DBT/SM) technique compared to calcifications detected using the full-field digital (DM) technique.

Methods
This retrospective study was IRB approved. The records for all stereotactic biopsies performed for suspicious calcifications detected on screening mammograms using DM in 2011–2014 and DBT/SM in 2017–2020 were reviewed. We collected patient, imaging, and pathology data from the breast imaging database and from retrospective review of a subset of mammograms. The biopsy outcome results were categorized as benign, benign with upgrade potential (BWUP), and malignant based on final pathology. Frequencies and proportions of outcomes were calculated and compared using Mann-Whitney U tests and Wilcoxson signed-rank tests with P-values and 95% confidence intervals (95% CIs).

Results
From 2011 to 2014 (DM), 1274 stereotactic biopsies of calcifications yielded 74.2% (945/1274) benign, 11.5% (147/1274) BWUP, and 14.3% (182/1274) malignant outcomes. From 2017 to 2020 (DBT/SM), 1049 stereotactic biopsies yielded 65.2% (684/1049) benign, 15.6% (164/1049) BWUP, and 19.2% (201/1049) malignant outcomes. With DBT/SM, benign biopsy outcomes decreased (9.0%, 95% CI 0.87–11.53, P &lt; 0.05), whereas malignant biopsy outcomes increased (4.9%, 95% CI 0.94–8.36, P &lt; 0.05). There was no significant difference in BWUP biopsy outcomes and total biopsy rates between techniques (P &gt; 0.05).

Conclusion
Calcifications detected with screening DBT/SM technique were significantly more likely to be malignant than those found using DM. These results support using the DBT/SM technique without obtaining concurrent DM images.
Starbursts driven by central gas compaction
Authors: Cenci Elia , Feldmann Robert , Gensior Jindra , Moreno Jorge , Bassini Luigi , Bernardini Mauro 
Published: December 2023

ABSTRACT
Starburst (SB) galaxies are a rare population of galaxies with star formation rates (SFRs) greatly exceeding those of the majority of star-forming galaxies with similar stellar mass. It is unclear whether these bursts are the result of either especially large gas reservoirs or enhanced efficiencies in converting gas into stars. Tidal torques resulting from gas-rich galaxy mergers are known to enhance the SFR by funnelling gas towards the centre. However, recent theoretical works show that mergers do not always trigger an SB and not all SB galaxies are interacting systems, raising the question of what drives an SB. We analyse a large sample of SB galaxies and a mass- and redshift-matched sample of control galaxies, drawn from the FIREbox cosmological volume at z = 0–1. We find that SB galaxies have both larger molecular gas fractions and shorter molecular depletion times than control galaxies, but similar total gas masses. Control galaxies evolve towards the SB regime by gas compaction in their central regions, over time-scales of ∼70 Myr, accompanied by an increase in the fraction of ultradense and molecular gas. The driving mechanism behind the SB varies depending on the mass of the galaxy. Massive ($M_\star \gtrsim 10^{10}~\rm {M}_\odot$) galaxies undergoing intense, long-lasting SBs are mostly driven by galaxy interactions. Conversely, SBs in non-interacting galaxies are often triggered by a global gravitational instability, which can result in a ‘breathing’ mode in low-mass galaxies.
Jellyfish galaxies with the IllustrisTNG simulations – citizen-science results towards large distances, low-mass hosts, and high redshifts
Authors: Zinger Elad , Joshi Gandhali D , Pillepich Annalisa , Rohr Eric , Nelson Dylan 
Published: December 2023

ABSTRACT
We present the ‘Cosmological Jellyfish’ project – a citizen-science classification program to identify jellyfish (JF) galaxies within the IllustrisTNG cosmological simulations. JF are satellite galaxies that exhibit long trailing gas features – ‘tails’ – extending from their stellar body. Their distinctive morphology arises due to ram-pressure stripping (RPS) as they move through the background gaseous medium. Using the TNG50 and TNG100 simulations, we construct a sample of $\sim 80\, 000$ satellite galaxies spanning an unprecedented range of stellar masses, $10^{8.3}{-}10^{12.3}\, \mathrm{M_\odot }$, and host masses, $M_\mathrm{200,c}=10^{10.4}{-}10^{14.6}\, \mathrm{M_\odot }$ back to z = 2. Based on this sample, $\sim 90\, 000$ galaxy images were presented to volunteers in the citizen-science Zooniverse platform, who were asked to determine whether the galaxy image resembles a JF. Based on volunteer votes, each galaxy received a score determining if it is a JF or not. This paper describes the project, the inspected satellite sample, the methodology, and the classification process that resulted in a data set of 5307 visually identified JF galaxies. We find that JF is common in nearly all group- and cluster-sized systems, with the JF fraction increasing with host mass and decreasing with satellite stellar mass. We highlight JF galaxies in three relatively unexplored regimes: low-mass hosts of $M_\mathrm{200,c}\sim 10^{11.5}{-}10^{13}\, \mathrm{M_\odot }$, radial positions within hosts exceeding the virial radius R200, c, and at high redshift up to z = 2. The full data set of our JF scores is publicly available and can be used to select and study JF galaxies in the IllustrisTNG simulations.
Impact of More Intense Smoking Parameters and Flavor Variety on Toxicant Levels in Emissions of a Heated Tobacco Product
Authors: Davigo Michele , Klerx Walther N M , van Schooten Frederik-Jan , Opperhuizen Antoon , Remels Alexander H V , Talhout Reinskje 
Published: December 2023

Abstract

Introduction
IQOS HEETS are promoted as reduced-risk alternatives to cigarettes. Although some studies have investigated the chemical composition of HEETS emissions, little is known on whether toxicant levels in such emissions are affected by different puffing parameters and flavor varieties. This has important implications when assessing actual human exposure, since IQOS users develop a specific and personalized puffing behavior and may use different HEETS variants.

Methods
This study measured the levels of nicotine, total particulate matter, carbonyl compounds, and tobacco-specific nitrosamines (TSNAs) in the emissions of nine differently flavored HEETS and two cigarettes (1R6F and Marlboro Red, MR). Emissions from Yellow HEETS, 1R6F, and MR were collected using the World Health Organization Intense smoking regime and four more intense smoking regimes.

Results
Yellow HEETS aerosol contained lower levels of toxicants compared to 1R6F and MR smoke. More intense smoking regimes increased carbonyl release in cigarette smoke, whereas only higher puff frequency led to lower levels of toxicants in Yellow HEETS aerosol. Some HEETS varieties exhibited higher levels of formaldehyde and TSNAs in their aerosols compared to Yellow HEETS.

Conclusions
Puff frequency was identified as the only smoking parameter that significantly lowered the release of almost all toxicants in Yellow HEETS, whereas a combination of higher puff volume and puff duration led to increased levels of some carbonyls. Differences in toxicant levels between various commercially available HEETS have important implications when assessing their health impact, as their consumption might induce different toxicant exposure and health effects.

Implications
HEETS release about half as much nicotine and substantially lower levels of toxicants compared to cigarettes. Literature data showed that puffing intensity is increased in cigarette smokers switching to HEETS, maybe in reaction to these lower nicotine levels. Our results show a differential impact of increased puff frequency, puff duration, and puff volume in the release of toxicants from HEETS. Thus, industry-independent studies on puff topography are critical to make choices for the most relevant puffing regime for heated tobacco product regulation. Regulators should consider evaluating the health impact of multiple HEETS varieties, as the tobacco filler composition significantly affects the release of certain toxicants.
Forces driving transposable element load variation during Arabidopsis range expansion
Authors: Jiang Juan , Xu Yong-Chao , Zhang Zhi-Qin , Chen Jia-Fu , Niu Xiao-Min , Hou Xing-Hui , Li Xin-Tong , Wang Li , Zhang Yong E , Ge Song , Guo Ya-Long 
Published: December 2023

Abstract
Genetic load refers to the accumulated and potentially life-threatening deleterious mutations in populations. Understanding the mechanisms underlying genetic load variation of transposable element (TE) insertion, a major large-effect mutation, during range expansion is an intriguing question in biology. Here, we used 1,115 global natural accessions of Arabidopsis (Arabidopsis thaliana) to study the driving forces of TE load variation during its range expansion. TE load increased with range expansion, especially in the recently established Yangtze River basin population. Effective population size, which explains 62.0% of the variance in TE load, high transposition rate, and selective sweeps contributed to TE accumulation in the expanded populations. We genetically mapped and identified multiple candidate causal genes and TEs, and revealed the genetic architecture of TE load variation. Overall, this study reveals the variation in TE genetic load during Arabidopsis expansion and highlights the causes of TE load variation from the perspectives of both population genetics and quantitative genetics.