bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of organization of cervical and breast cancer screening programmes in the Latin American and the Caribbean states: The CanScreen5 framework
Authors: Mosquera Isabel , Barajas Clara B. , Zhang Li , Lucas Eric , Benitez Majano Sara , Maza Mauricio , Luciani Silvana , Basu Partha , Carvalho Andre L. 
Published: September 2023

AbstractBackgroundIn the Community of Latin American and Caribbean States (CELAC), breast cancer and cervical cancer are the first and third causes of cancer death among females. The objectives are to assess the characteristics of the cervical and breast cancer screening programmes in CELAC, their level of organization, and the association of screening organization and coverage of essential health services.MethodsRepresentatives of the Ministries of Health of 33 countries were invited to the CanScreen5 project. Twenty‐seven countries participated in a “Train The Trainers” programme on cancer screening, and 26 submitted data using standardized questionnaires. Data were discussed and validated.The level of organization of the screening programmes was examined adapting the list of essential elements of organized screening programmes identified in a recently published IARC study.ResultsTwenty‐one countries reported a screening programme for cervical cancer and 15 for breast cancer. For cervical cancer, 14 countries dedicated budget for screening (66.7%), and women had to pay in 3 countries for screening (14.3%), 9 for diagnosis (42.9%) and 8 for treatment (38.1%). Only 4 countries had a system to invite women individually (19.0%). For breast cancer, 8 countries dedicated budget for screening (53.3%), and women had to pay for screening in 3 countries (20.0%), diagnosis in 7 (46.7%) and treatment in 6 (40.0%). One country (6.7%) invited women individually.There was variability in the level of organization of both cancer screening programmes. The level of organization of cervical cancer screening and coverage of essential health services were correlated.ConclusionLarge gaps were identified in the organization of cervical and breast cancer screening services. CELAC governments need pragmatic public health policies and strengthened health systems. They should guarantee sustainable funding, and universal access to cancer diagnosis and treatment. Moreover, countries should enhance their health information system and ensure adequate monitoring and evaluation.
Clinical characteristics and risk factors of acute lymphoblastic leukemia in children with severe infection during maintenance treatment
Authors: Yin Tiantian , Han Juan , Hao Jinjin , Yu Hui , Qiu Yining , Xu Jiawei , Peng Yun , Wu Xiaoyan , Jin Runming , Zhou Fen 
Published: September 2023

AbstractBackgroundInfection is the most common adverse event of acute lymphoblastic leukemia (ALL) treatment and is also one of the main causes of death.MethodsTo investigate the clinical characteristics and risk factors of severe infections during the maintenance phase of ALL treatment, we conducted a retrospective study.ResultsA total of 181 children were eligible and 46 patients (25.4%) suffered from 51 events of severe infection, most of which occurred in the first half year of the maintenance phase (52.9%). The most common infection was pulmonary infection (86.3%) followed by bloodstream infection (19.6%). The main symptoms of ALL patients with pulmonary infection were fever, cough, and shortness of breath. The main manifestations of computer tomography (CT) were ground glass shadow (56.8%), consolidation shadow (27.3%), and streak shadow (25%). Multivariate binary logistic regression analysis showed that agranulocytosis, agranulocytosis ≥7 days, anemia, and low globulin level were independent risk factors for severe infection during the maintenance phase (all p < 0.05).ConclusionsTaken together, blood routine examinations and protein levels should be monitored regularly for ALL patients in the maintenance phase, especially in the first 6 months. For ALL patients with risk factors, preventive anti‐infective or supportive therapies can be given as appropriate to reduce the occurrence of severe infections.
Risk factors for the failure of first‐line PARP inhibitor maintenance therapy in patients with advanced ovarian cancer: Gynecologic Oncology Research Investigators Collaboration Study (GORILLA‐3004)
Authors: Kim Nam Kyeong , Kim Yeorae , Kim Hee Seung , Park Soo Jin , Hwang Dong Won , Lee Sung Jong , Yoo Ji Geun , Chang Suk‐Joon , Son Joo‐Hyuk , Kong Tae‐Wook , Kim Jeeyeon , Shim Seung‐Hyuk , Lee A Jin , Suh Dong Hoon , Lee Yoo‐Young 
Published: September 2023

AbstractObjectiveTo identify the risk factors for failure of first‐line poly (ADP‐ribose) polymerase inhibitor (PARPi) maintenance therapy in patients with advanced ovarian cancer.MethodPatients with stage III‐IV epithelial ovarian cancer who received first‐line PARPi maintenance therapy were retrospectively reviewed. Clinicopathologic factors were compared between two groups—recur/progression of disease (PD) and non‐recur/PD.ResultsIn total, 191 patients were included. Median follow‐up was 9.9 months, and recurrence rate was 20.9%. BRCA mutations were found in 63.4% patients. Postoperative residual tumor (60.5% vs. 37.8%), non‐high grade serous carcinoma (HGSC) (15.0% vs. 6.0%), neoadjuvant chemotherapy (NAC) (55.0% vs. 35.8%), and pre‐PARPi serum CA‐125 levels ≥23.5 U/mL (35.9% vs. 15.2%) were more frequently observed in the recur/PD group. Multivariate Cox‐regression analysis revealed pre‐PARPi serum CA‐125 levels ≥23.5 U/mL (HR, 2.17; 95%CI, 1.03–4.57; p = 0.042), non‐HGSC (3.28; 1.20–8.97; p = 0.021), NAC (2.11; 1.04–4.26; p = 0.037), and no BRCA mutation (2.23; 1.12–4.44; p = 0.023) as independent risk factors associated with poor progression‐free survival (PFS). A subgroup analysis according to BRCA mutation status showed that pre‐PARPi serum CA‐125 levels ≥26.4 U/mL were the only independent risk factor for poor PFS in women with BRCA mutations (2.75; 1.03–7.39; p = 0.044). Non‐HGSC (5.05; 1.80–14.18; p = 0.002) and NAC (3.36; 1.25–9.04; p = 0.016) were independent risk factors in women without BRCA mutations.ConclusionHigh pre‐PARPi serum CA‐125 levels, non‐HGSC histology, NAC, and no BRCA mutation might be risk factors for early failure of first‐line PARPi maintenance therapy. In women with BRCA mutations, high pre‐PARPi serum CA‐125 levels, which represent a large tumor burden before PARPi, were the only independent risk factor for poor PFS.
Longitudinal associations among physical activity and sitting with endocrine symptoms and quality of life in breast cancer survivors: A latent growth curve analysis
Authors: Lucas Alexander R. , Kim Youngdeok , Lanoye Autumn , Franco R. Lee , Sutton Arnethea L. , LaRose Jessica G. , Ross Masey , Sheppard Vanessa B. 
Published: September 2023

AbstractPurposeAdjuvant endocrine therapy (AET) often causes debilitating endocrine symptoms that compromise quality of life (QOL) in women diagnosed with hormone receptor positive breast cancer (BC). We examined whether greater levels of physical activity (PA) or prolonged sitting were associated with reduced side effects or worse side effects of AET, respectively.MethodsWe used parallel process latent growth curve models to examine longitudinal patterns in PA and sitting behaviors, and their association with endocrine symptoms and QOL over 3 years of follow‐up in 554 female BC survivors undergoing AET.ResultsAt baseline, women were a mean age of 59 years, mostly white (72%), with overweight/obesity (67%), and approximately 50% were within 1 year of diagnosis. Unconditional models showed significant increases in PA (p < 0.01) over time but no change in sitting. Endocrine symptoms, general and BC‐specific QOL all significantly worsened over time (p < 0.01). Parallel process models showed no cross‐sectional or longitudinal associations between PA and endocrine symptoms. Higher levels of baseline PA were associated with higher baseline QOL scores (p = 0.01) but changes in PA were not associated with changes in QOL. Conversely, more sitting at baseline was associated with worse endocrine symptoms, general and BC specific QOL (ps <0.01). At baseline, having better QOL scores was associated with increases in sitting (ps <0.01), while having worse endocrine symptoms was associated with a slower rate of increase in sitting (p < 0.01). Increases in sitting time were also associated with a slower rate of increase in endocrine symptoms (p = 0.017). Model fit statistics (x2, CFI, TLI, SRMR) were acceptable.ConclusionBoth PA and sitting behaviors are important for the management of symptoms and in maintaining QOL in BC survivors. Women with already high symptom burden do not increase sitting time further but having better general and BC specific QOL to begin with means a greater decline over time.
Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report
Authors: Shiravani Zahra , Bahrami Samaneh , Najib Fateme Sadat , Alavi Seyed Mohammad Amin 
Published: September 2023

Key Clinical MessageTo date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor.AbstractBrenner tumor is a rare epithelial ovarian neoplasm responsible for 2%–3% of all ovarian tumors. These tumors are usually asymptomatic and can usually be found incidentally in pathological studies. They can also manifest themselves as abdominal pain or abnormal uterine bleeding. A 41‐year‐old female with a history of anemia referred to the hospital suffering from abdominal pain for at least 1 month before the referral period. Physical examination revealed a mobile palpable mass in the left lower abdomen. Ultrasound and pelvic computed tomography scan (CT scan) revealed a left ovarian complex cyst. Left salpingo‐oophorectomy was performed on the patient, and the cyst was removed. Pathological findings revealed an atypical proliferative Brenner tumor with mucinous metaplasia. To date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor.
Choriocarcinoma in tubal pregnancy: A case report
Authors: Najib Fateme Sadat , Bahrami Samaneh , Shiravani Zahra , Alavi Seyed Mohammad Amin 
Published: September 2023

Key Clinical MessageChoriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.AbstractChoriocarcinoma is a malignant epithelial tumor of the chorionic villi that often manifests after a normal or molar pregnancy. The primary tubal choriocarcinoma associated with ectopic pregnancy is extremely rare and can be misdiagnosed as an ectopic pregnancy since symptoms including vaginal bleeding, amenorrhea, elevated beta‐human chorionic gonadotropin (BHCG) levels, and pelvic pain are shared. A 34‐year‐old G4P3003 woman presented with a one‐week history of vaginal bleeding and right lower abdominal pain, which had intensified a day before admission. Clinical and paraclinical examinations pointed to a ruptured tubal pregnancy; hence, an emergency laparotomy was performed, and a right salpingectomy was carried out on the patient. However, a nonsignificant decline in BHCG level was observed, and histological examination revealed tubal choriocarcinoma; hence, a metastasis workup was carried out, yet no metastasis was detected. Six sessions of chemotherapy consisting of Etoposide, Methotrexate, Dactinomycin, Cyclophosphamide, and Vincristine (EMA‐CO) were administered without complication, in such a way that the BHCG level normalized after three sessions of chemotherapy. Evaluations after 1 year from the completion of chemotherapy revealed that the patient had no subsequent problems. Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Metastasis workup should be considered for all individuals with choriocarcinoma. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.
Rare non‐trophoblastic vascular placental tumor: A diagnostic challenge
Authors: Limaiem Faten , Amor Anissa Ben , Saffar Khalil , Halouani Ahmed 
Published: September 2023

Key Clinical MessagePathologists should consider the differential diagnoses of placental chorioangioma, which encompass chorangiosis, chorangiomatosis, chorangiocarcinoma, intervillous thrombus, and placental infarct.AbstractChorioangiomas are rare non‐trophoblastic vascular neoplasms of the placenta, occurring in approximately 1% of pregnancies. Large chorioangiomas (>4 cm) are infrequent and associated with an increased risk of pregnancy complications. There are limited reports in the literature regarding uncomplicated cases of large placental chorioangiomas.
Elucidating the Effect of Nitrogen Occupancy on the Hydrogen Evolution Reaction for a Series of Titanium Oxynitride Electrocatalysts
Authors: Yang Guangmeimei , Zhou Yuxiang , Wang Mengnan , Murawski James , Oldham Louise I. , Tian Tian , Stephens Ifan E. L. , Kafizas. Andreas 
Published: September 2023

AbstractTitanium nitride (TiN) shows desirable properties for use as an electrocatalyst and catalyst support, as it possesses high electrical conductivity and excellent corrosion resistance. However, the effect of oxygen content in the nitride lattice on its ability to drive the hydrogen evolution reaction (HER) is not well understood. Here, a series of titanium oxynitrides (TiNxO1‐x) with varied nitrogen occupancy (0.53≤x≤1.0) in the bulk have been fabricated by ammonolysis. Their specific activities towards the HER were normalised by the surface areas determined by BET and electrochemical methods. We show that the specific activities of these oxynitrides are strongly correlated with the bulk nitrogen occupancy, despite the similar surface composition derived from XPS analysis. Furthermore, a removal of the oxygen content in the bulk or at the surface was attributed to the upgraded performance (up to 25 % increase) seen during extended chronoamperometry (CA) tests. Our results show that minimising bulk oxygen content in this class of material is critical to achieve a more conductive and active material for the HER.
Oxidative Dehydrogenation of Propane over Supported Nickel Single‐Atom Catalyst†
Authors: Zhang Qian , Jiang Xunzhu , Li Yangyang , Tan Yuanlong , Jiang Qike , Liu Xiaoyan , Qiao Botao 
Published: September 2023

Comprehensive SummaryOxidative dehydrogenation of propane has been an ever‐growing field for propylene production due to its exothermic properties, of which overoxidation is the major drawback, with CO and even CO2 as undesired by‐products. For the purpose of getting higher propylene selectivity as well as yield, herein, we report Ni single atoms supported on calcium aluminate as an efficient catalyst candidate for propane oxidative dehydrogenation. Beneficial from higher valence states of Ni1 species, it shows 2—3 times as much propylene selectivity as that of Ni nanoparticles. About 14.2% C3H6 yield with 47.3% propylene selectivity has been achieved on Ni single atom catalyst and a good stability during 20 h test can be obtained as well.
Thixotropic Hydrogels Based on Laponite® and Cucurbituril for Delivery of Lipophilic Drug Molecules
Authors: Massaro Marina , Cinà Giuseppe , Borrego‐Sánchez Ana , Sainz‐Díaz C. Ignacio , Viseras‐Iborra César , Sánchez‐Espejo Rita , de Melo Barbosa Raquel , Leone Federica , Pibiri Ivana , Noto Renato , Riela Serena 
Published: September 2023

AbstractNowadays the use of hydrogels for biomedical purposes is increasing because of their interesting features that allow the development of targeted drug delivery systems. Herein, hydrogel based on Laponite® (Lap) clay mineral as gelator and cucurbit[6]uril (CB[6]) molecules were synthetized for the delivery of flufenamic acid (FFA) for potential topical application. Firstly, the interaction between CB[6] and FFA was assessed by UV‐vis spectroscopic measurements and molecular modeling calculations. Then, the obtained complex was used as filler for Lap hydrogel (Lap/CB[6]/FFA). The properties of the hydrogel in terms of viscosity and, self‐repair abilities were investigated; its morphology was imaged by scanning electron and polarized optical microscopies. Furthermore, the changes in the hydrodynamic radii and in the colloidal stability of CB[6]/Lap mixture were investigated in terms of translational diffusion from dynamic light scattering and ζ‐potential measurements. Finally, the kinetic in vitro release of FFA, from Lap/CB[6]/FFA hydrogel, was studied in a medium mimicking the pH of skin and the obtained results were discussed both by an experimental point of view and by molecular modeling calculations.
Analytical assay validation for acute myeloid leukemia measurable residual disease assessment by multiparametric flow cytometry
Authors: Tettero Jesse M. , Dakappagari Naveen , Heidinga Maaike E. , Oussoren‐Brockhoff Yvonne , Hanekamp Diana , Pahuja Anil , Burns Kerri , Kaur Pavinder , Alfonso Zeni , van der Velden Vincent H. J. , te Marvelde Jeroen G. , Hobo Willemijn , Slomp Jennichjen , Bachas Costa , Kelder Angele , Nguyen Kevin , Cloos Jacqueline 
Published: September 2023

AbstractBackgroundMeasurable residual disease (MRD) assessed by multiparametric flow cytometry (MFC) has gained importance in clinical decision‐making for acute myeloid leukemia (AML) patients. However, complying with the recent In Vitro Diagnostic Regulations (IVDR) in Europe and Food and Drug Administration (FDA) guidance in the United States requires rigorous validation prior to their use in investigational clinical trials and diagnostics. Validating AML MRD‐MFC assays poses challenges due to the unique underlying disease biology and paucity of patient specimens. In this study, we describe an experimental framework for validation that meets regulatory expectations.MethodsOur validation efforts focused on evaluating assay accuracy, analytical specificity, analytical and functional sensitivity (limit of blank (LoB), detection (LLoD) and quantitation (LLoQ)), precision, linearity, sample/reagent stability and establishing the assay background frequencies.ResultsCorrelation between different MFC methods was highly significant (r = 0.99 for %blasts and r = 0.93 for %LAIPs). The analysis of LAIP specificity accurately discriminated from negative control cells. The assay demonstrated a LoB of 0.03, LLoD of 0.04, and LLoQ of 0.1%. Precision experiments yielded highly reproducible results (Coefficient of Variation <20%). Stability experiments demonstrated reliable measurement of samples up to 96 h from collection. Furthermore, the reference range of LAIP frequencies in non‐AML patients was below 0.1%, ranging from 0.0% to 0.04%.ConclusionIn this manuscript, we present the validation of an AML MFC‐MRD assay using BM/PB patient specimens, adhering to best practices. Our approach is expected to assist other laboratories in expediting their validation activities to fulfill recent health authority guidelines.
DBU Promoted Deformylative/Dehalogenative Difunctionalization to Access β‐Bromovinyl Aldehydes Derived from Tetralones**
Authors: Sau Madan , Dubey Sapana , Roy Shreya , Samanta Shubhankar , Das Tapas 
Published: September 2023

AbstractHerein we have disclosed metal‐free 1,8‐diazabicyclo(5.4.0)undec‐7‐ene (DBU)‐catalyzed protocol for the deformylative/dehalogenative carbonylation and Michael addition of β‐bromovinyl aldehydes with acrylates and carbonylation followed by etherification with benzyl bromides to synthesize δ‐oxo esters and vinyl ethers respectively in good yields under an open atmosphere with broad substrate scope. Regeneration of starting material from vinyl ethers, organo‐catalytic and nucleophilic behavior of DBU is also discussed.
Biodiesel production through the transesterification of rapeseed oil over CaO‐MgO/SBA‐15 catalysts
Authors: Lazdovica Kristine , Kampars Valdis , Gaile Anastasija 
Published: September 2023

AbstractDesigning a cost‐effective and environmentally friendly heterogeneous catalyst for biodiesel production is essential. To achieve this, new 0.3‐CaO‐MgO/SBA‐15 and 0.8‐CaO‐MgO/SBA‐15 catalysts were prepared by the impregnation method. The new 0.3‐CaO‐MgO/SBA‐15 catalyst had higher purity, larger surface area, and pore volume than 0.8‐CaO‐MgO/SBA‐15, resulting in great catalytic activity for biodiesel production by transesterification of rapeseed oil with methanol. A biodiesel yield of 97.8 wt % was attained under the optimal reaction conditions of 5 wt % catalyst concentration, 15:1 methanol/oil molar ratio, 95°C reaction temperature, and reaction time of 4 h. Most of the parameters and properties of the obtained biodiesel correspond to the EN 14212 standard. The 0.3‐CaO‐MgO/SBA‐15 catalyst could be considered a potential candidate for biodiesel production on industrial level application attributed to intriguing properties like cost‐effectiveness, ease of synthesis, and environmental greenness.
Determination of the maximum run‐off sediment transport capacity during a rainstorm flood in a small watershed on the Loess Plateau
Authors: Wang Chenguang , Li Zhanbin , Wang Shanshan 
Published: September 2023

AbstractThe channel sediment transport capacity is an important parameter in soil erosion models, and it determines the proportion of soil erosion that is sent outside the watershed. However, the calculation and judgment methods for the sediment transport capacity of channel are still incomplete, and further research is needed. Therefore, this paper takes Chabagou, a typical watershed in the hilly and gully region of the Loess Plateau, as an example and, based on the measured hydrological and sediment data collected during rainstorm floods in 1961–1969 at three hydrological stations, Caoping, Shejiagou, and Tuanshangou, studies the sediment transport capacity of channels in a small watershed from the perspective of energy dissipation. Clearly, the sediment transport capacity is better determined by using a single flood and sediment concentration peak process. The discriminant conditions are determined for the sediment concentration to reach sediment transport capacity during the flood rising and falling sections of the sediment process of the small watershed storm flood. When determining sediment transport capacity based on the characteristics of the flood and sediment concentration peak, we find that sediment transport capacity is reached in the flood discharge peak when the flood discharge peak occurs earlier than the sediment concentration peak. When determining sediment transport capacity based on the flow discharge and sediment concentration characteristics of the sediment fall section, we find that when the flood event exhibits a counterclockwise hysteresis curve and a time‐lagged effect occurs, the sediment concentration at that time reaches sediment transport capacity. In this study, the sediment concentration as a function of run‐off amount is logarithmic at different subbasin scales when run‐off reaches its maximum capacity to transport sediment. The R2 is high, ranging from 0.78 to 0.92. The results of this research provide a reference for the study of sediment transport capacity.