bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotionally based school non‐attendance: Development of a local authority, multi‐agency approach to supporting regular attendance
Authors: Corcoran Shannon , Kelly Catherine , Bond Caroline , Knox Louise 
Published: December 2023

AbstractAccording to Government guidance in the UK, improving attendance is everyone's business. This article sets out the work of one local authority to develop their own multi‐agency approach to reduce rates of emotionally based school non‐attendance. The Research and Development in Organisations model provided a structure for the action research process, which consisted of cycles of action and reflection, including awareness raising, reflections on current practice, and the integration of stakeholder views, resulting in an organisational culture shift and the production of professional guidance materials. Content analysis suggests that the development of a localised approach required time, with multi‐agency collaboration to promote shared ownership of the products and processes across all stakeholders and to enhance uptake of positive changes to practice. Factors that facilitated the process included response to local need, multi‐agency collaboration and positive feedback, while diminished capacity and misconceptions about roles and responsibilities in monitoring and improving attendance were barriers to change. The findings provide further evidence for the role of multi‐agency working in the development of strategic support for school attendance difficulties to promote organisational change. Future research should evaluate the effectiveness of these approaches to better inform future support at an organisational level.
Phosphorylated vimentin at Ser72 is associated with epithelial–mesenchymal transition in lupus nephritis
Authors: Wang Daji , Zhang Fan , He Jing , Li Chuyi , Liu Xingjiao , Zhang Meng , Huang Haihui , Xiong Zuying , Duan Hongxia , Huang Xiaoyan , Wang Meiying 
Published: December 2023

AbstractObjectivesTo measure the expression of vimentin and its phosphorylated forms in lupus nephritis (LN) and explore their potential role in LN development.MethodsLupus renal biopsies from LN patients and normal renal biopsies from kidney transplant donors were collected. The expression of vimentin and its phosphorylated forms (p‐vimentin (Ser39, Ser56, Ser72, Ser83, and Tyr117)) were measured by Western blots and immunohistochemistry. To construct stable cell line that overexpress vimentin and its phosphorylated forms, an immortalized proximal tubule epithelial cell line (HK‐2 cells) was utilized. The roles of vimentin and its phosphorylated forms on the migration of HK‐2 cells were examined by transwell migration assay and wound healing analysis.ResultsWe first observed a significant upregulation of vimentin protein in TGFβ1‐induced HK‐2 cells. This finding was further confirmed in renal tissues obtained from LN patients and animal model. Interestingly, among the five phosphorylated forms of vimentin, only vimentin phosphorylated at Ser72 was upregulated in LN. Through the establishment of stable vimentin and its phosphorylated forms overexpression in HK‐2 cells, we found that the overexpression of vimentin and its phosphorylated forms at Ser72 significantly enhances the cell migration.ConclusionsVimentin phosphorylated on Ser72 is important for renal epithelial cell migration, which would enhance the progression of vimentin‐induced epithelial–mesenchymal transition during LN development.
Clinical and sociodemographic features in offspring aged 0–3 years of mothers with schizophrenia spectrum disorders. A descriptive cross‐sectional study
Authors: Edvardsen Emilie , Moszkowicz Mala , Olsen Anne Lise , Heinrichsen Michella , Pagsberg Anne Katrine 
Published: December 2023

AbstractObjectiveOffspring of parents with schizophrenia spectrum disorders (SSD) have an increased risk of neurodevelopmental disturbances. However, the ability to provide very early interventions to support these children and their families requires profound knowledge regarding characteristic features of both the parents and their offspring. Information on this subject is currently sparse. The aim of the present study is to investigate clinical and sociodemographic variables in offspring in the age range of 0–3 years of mothers diagnosed with SSD.MethodsThe study is descriptive with a cross‐sectional design and includes parent‐child dyads consisting of mothers diagnosed with SSD (ICD‐10: F20‐29) and their offspring aged 0‐3 years, who were referred for examination and intervention at the infant and toddler psychiatric units, at the Mental Health Services, Capital Region, Copenhagen University Hospitals in two locations (Bispebjerg and Glostrup). Clinical and sociodemographic data were extracted from the Copenhagen “Infant Psychiatric Database” and processed by descriptive analysis.ResultsOut of 95 parent–child dyads considered for the study population, 85 were included. 27.8% of the mothers had psychiatric comorbidities, and 18.9% of the fathers had a psychiatric diagnosis at the time of investigation. Of the children, 89.7% were born full term (≥37th week) and most of them had a birth weight of ≥2500 g (81.8%). Of the mothers, 50% had experienced pregnancy complications of varying severity. Birth complications were seen in 62.9% of the dyads. Psychopathology was identified in 50% of the children at age 0–3 years, and 62.2% of the parent–child dyads appeared to have an affected relationship.ConclusionResults show widespread psychopathology in offspring aged 0–3 years of mothers with SSD. Moreover, several psychosocial stressors, clinical parental features, and relational disturbances are identified. These results contribute to a better understanding and identification of early risk markers of long‐term psychopathology in this infant patient group, and hence serve as potential targets for early interventions.
Anthropology's good beyond the discipline
Authors: Deeb Lara , Winegar Jessica 
Published: December 2023

AbstractIn July 2023, the American Anthropological Association's (AAA) members voted to boycott Israeli academic institutions until they end their complicity in violating Palestinian rights as stipulated in international law. The AAA's adoption of this resolution shows the potential good of anthropology, both within and beyond the academy. Anthropology's disciplinary scholarly processes, methods, and theoretical frameworks paved the way for this resolution, providing one answer to the question, What good is anthropology?
An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs
Authors: Moyer Jarrett C. , Chivukula Venkat Keshav , Taheri‐Tehrani Parsa , Sandhu Sukhveer , Blaha Charles , Fissell William H. , Roy Shuvo 
Published: December 2023

AbstractBackgroundSilicon nanopore membrane‐based implantable bioartificial organs are dependent on arteriovenous implantation of a mechanically robust and biocompatible hemofilter. The hemofilter acts as a low‐resistance, high‐flow network, with blood flow physiology similar to arteriovenous shunts commonly created for hemodialysis access. A mock circulatory loop (MCL) that mimics shunt physiology is an essential tool for refinement and durability testing of arteriovenous implantable bioartificial organs and silicon blood‐interfacing membranes. We sought to develop a compact and cost‐effective MCL to replicate flow conditions through an arteriovenous shunt and used data from the MCL and swine to inform a bond graph mathematical model of the physical setup.MethodsFlow physiology through bioartificial organ prototypes was obtained in the MCL and during extracorporeal attachment to swine for biologic comparison. The MCL was tested for stability overtime by measuring pressurewave variability over a 48‐h period. Data obtained in vitro and extracorporeally informed creation of a bond graph model of the MCL.ResultsThe arteriovenous MCL was a cost‐effective, portable system that reproduced flow rates and pressures consistent with a pulsatile arteriovenous shunt as measured in swine. MCL performance was stable over prolonged use, providing a cost‐effective simulator for enhanced testing of peripherally implanted bioartificial organ prototypes. The corresponding bond graph model recapitulates MCL and animal physiology, offering a tool for further refinement of the MCL system.
Meaning in life following service among post‐9/11 military veterans: A latent growth mixture model analysis
Authors: Kumar Shaina A. , Borowski Shelby , Vogt Dawne 
Published: December 2023

AbstractMeaning in life refers to the “sense made of, and significance felt regarding, the nature of one's being and existence.” Meaningful living promotes well‐being, resilience, and personal growth. Yet, much remains unknown about how meaning changes over time and determinants of meaning, particularly during major life transitions. We identified distinct trajectories of meaning using latent growth mixture models and examined prospective predictors of class membership in a military veteran cohort assessed at multiple time points throughout the first 3 years after leaving service. Three trajectories were identified: consistently high meaning (89.5%; n = 7025), diminishing meaning (6.1%; n = 479), and strengthening meaning (4.4%; n = 348). Veterans with greater posttraumatic stress symptoms, depression symptoms, and moral injury experienced increased odds of a less adaptive trajectory (i.e. diminishing and/or strengthening vs. consistently high meaning), whereas veterans who reported greater psychological resilience, community relationship satisfaction, and intimate relationship satisfaction experienced lower odds of a less adaptive trajectory. Several gender differences were also observed. Results provide insight into veteran subgroups that are more likely to experience lower meaning after leaving military service and thus may benefit from additional support to reduce their risk for poor longer‐term health and well‐being outcomes.
Exploring the impact of ethnicity on drug pharmacokinetics using PBPK models: A case study with lansoprazole in Japanese subjects
Authors: Ezuruike Udoamaka , Curry Liam , Hatley Oliver , Gardner Iain 
Published: December 2023

AimsThe aim of this study is to demonstrate the use of PBPK modelling to explore the impact of ethnic differences on drug PK.MethodsA PBPK model developed for lansoprazole was used to predict the clinical PK of lansoprazole in Japanese subjects by incorporating the physiological parameters of a Japanese population into the model. Further verification of the developed Japanese population with clinical studies involving eight other CYP substrates—omeprazole, ticlopidine, alprazolam, midazolam, nifedipine, cinacalcet, paroxetine and dextromethorphan—was also carried out.ResultsThe PK of lansoprazole in both Caucasian and Japanese subjects was well predicted by the model as the observed data were within the 5th and 95th percentiles across all the clinical studies. In age‐ and sex‐matched simulations in both the Caucasian and Japanese populations, the predicted PK (mean ± SD) of a single oral dose of 30‐mg lansoprazole was higher in the Japanese population in all cases, with more than twofold higher AUC of 5.98 ± 6.43 mg/L.h (95% CI: 4.72, 7.24) vs. 2.46 ± 2.45 mg/L.h (95% CI: 1.98, 2.94) in one scenario. In addition, in two out of the nine clinical DDIs of lansoprazole and the additional CYP substrates simulated using the Japanese population, the predicted DDI in Japanese was more than 1.25‐fold that in Caucasians, indicating an increased DDI liability.ConclusionsBy accounting for various physiological parameters that characterize a population in a PBPK model, the impact of the different identified interethnic differences on the drug's PK can be explored, which can inform the adoption of drugs from one region to another.
Mode of birth and long‐term maternal mental health: A follow‐up study in the Danish National Birth Cohort
Authors: Hjorth Sarah , Skov Stina Kruse , Kirkegaard Helene , Olsen Jørn , Nohr Ellen Aagaard 
Published: December 2023

AbstractBackgroundCesarean birth has been associated with increased risks of short‐term mental health problems. Little is known about whether these associations persist in the long term. This study aimed to estimate the associations between mode of birth and maternal mental health in midlife while considering mental health before and during pregnancy.MethodsCohort study among mothers in the Danish National Birth Cohort. Birth mode for each woman's entire reproductive history was obtained from Danish national registries. Symptoms of depression and stress in midlife were self‐reported using validated scales. Log binomial regression was used to calculate risk ratios (RR) with 95% confidence intervals (CI) for the association between birth mode and depressive symptoms. Linear regression was used to calculate mean difference in stress score by birth mode.ResultsAmong 42,872 women, 15.5% reported depressive symptoms at follow‐up, where they were, on average, 43.9 years and 11.2 years after their last birth. Compared with women who only ever had spontaneous vaginal births, women who only had cesarean births, or had both cesarean and vaginal births with the last birth by cesarean, reported slightly more symptoms of depression (RR 1.10, 95% CI 1.01;1.20) and stress (mean difference 0.68 on a 100‐point scale, 95% CI 0.10;1.26).ConclusionWhether due to the birth experience or underlying factors, depression and stress in midlife were more frequent in women with only cesarean births or whose last birth was by cesarean compared with women with vaginal births.
Reduced Ca2+ mobilization in neonatal human platelets involves SARAF and pannexin‐1
Authors: Rosado Juan A. 
Published: December 2023

Platelets from neonates have been shown to exhibit a reduced response to physiological agonists, such as thrombin; however, the mechanism behind these findings is poorly understood. Berna‐Erro et al. now provide differences in SARAF and pannexin‐1 expression and function between neonatal and maternal platelets that might shed some light on the underlying mechanism.Commentary on: Berna‐Erro. SARAF overexpression impairs thrombin‐induced Ca2+ homeostasis in neonatal platelets. Br J Haematol 2024;204:988‐1004.
Front Cover
Authors: Perakakis Nikolaos , Bornstein Stefan R. , Birkenfeld Andreas L. , Linkermann Andreas , Demir Münevver , Anker Stefan D. , Filippatos Gerasimos , Pitt Bertram , Rossing Peter , Ruilope Luis M. , Kolkhof Peter , Lawatscheck Robert , Scott Charlie , Bakris George L. ,   FIDELIO‐DKD and FIGARO‐DKD investigators
Published: December 2023

The cover image is based on the Original Article Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis by Nikolaos Perakakis MD et al., https://doi.org/10.1111/dom.15305.image
Incremental prognostic value of speckle tracking echocardiography and early follow‐up echo assessment in predicting left ventricular recovery after reperfusion for ST‐segment elevation myocardial infarction (STEMI)
Authors: Yehia Ahmed , Zaki Amr , Sadaka Mohamed , Azeem Ahmed Mokhtar Abd El 
Published: December 2023

AbstractPurposeUp to 50% of patients do not achieve significant left ventricular ejection fraction (LVEF) recovery after primary percutaneous intervention (PPCI) for STEMI. We aimed to identify the echocardiographic predictors for LVEF recovery and assess the value of early follow‐up echocardiography (Echo) in risk assessment of post‐myocardial infarction (MI) patients.MethodsOne hundred one STEMI patients undergoing PPCI were enrolled provided EF below 50%. Baseline echocardiography assessed LVEF, volumes, wall motion score index (WMSI), global longitudinal strain (GLS), global circumferential strain (GCS), and E/e’. Follow‐up echocardiography after 6 weeks reassessed left ventricular volumes, LVEF and GLS.GCS was not assessed at follow up. Patients were classified into recovery and non‐recovery groups. Predictors of LVEF recovery and major adverse cardiovascular events (MACE) at 6 months were analysed.ResultsThe mean change of EF was 8.04 ± 3.32% in group I versus ‐.39 ± 5.09 % in group II (p < .001). Recovered patients had better baseline GLS, baseline GCS, E/e’, and follow‐up GLS. Multivariate regression analysis revealed E/e’, GCS, and follow‐up GLS after 6 weeks to be strong independent predictors for LVEF recovery. Composite MACE was considerably higher in group II (32.7% vs. 4.1%, p < .001) mainly driven by higher heart failure hospitalisation Multivariate regression analysis revealed baseline GLS, E/e’, and ejection fraction (EF) percentage recovery as strong independent predictors for MACE.ConclusionsMultiparametric echocardiographic approach incorporating LVEF, strain parameters, and diastolic function could allow early optimal risk stratification after STEMI treated with PPCI. Follow‐up GLS and LVEF percentage change are the strongest predictors for early LV recovery and long term clinical outcome, respectively.
Linking pollen limitation and seed dispersal effectiveness
Authors: Leal Laura C. , Koski Matthew H. 
Published: December 2023

AbstractSeed production and dispersal are crucial ecological processes impacting plant demography, species distributions and community assembly. Plant–animal interactions commonly mediate both seed production and seed dispersal, but current research often examines pollination and seed dispersal separately, which hinders our understanding of how pollination services affect downstream dispersal services. To fill this gap, we propose a conceptual framework exploring how pollen limitation can impact the effectiveness of seed dispersal for endozoochorous and myrmecochorous plant species. We summarize the quantitative and qualitative effects of pollen limitation on plant reproduction and use Optimal Foraging Theory to predict its impact on the foraging behaviour of seed dispersers. In doing so, we offer a new framework that poses numerous hypotheses and empirical tests to investigate links between pollen limitation and seed dispersal effectiveness and, consequently, post‐dispersal ecological processes occurring at different levels of biological organization. Finally, considering the importance of pollination and seed dispersal outcomes to plant eco‐evolutionary dynamics, we discussed the implications of our framework for future studies exploring the demographic and evolutionary impacts of pollen limitation for animal‐dispersed plants.
What drives closed‐end fund discounts? Evidence from COVID‐19
Authors: Ma Liang 
Published: December 2023

AbstractThis paper investigates the impact of the onset of the COVID‐19 pandemic in the United States on closed‐end fund (CEF) discounts. I show that CEF discounts increased after the onset of the COVID‐19 pandemic in the United States, while individual investor sentiment declined. Furthermore, CEFs with higher retail ownership had a larger discount increase, which suggests that individual investor sentiment is a potential contributor to CEF discounts. This finding seems less likely to be driven by rational channels or income‐driven fire sales, as shown by further analysis. Overall, the results shed light on the CEF discount puzzle using a new setting.
Genotype by environment model predictive ability in Miscanthus
Authors: Widener Sarah , Njuguna Joyce N. , Clark Lindsay V. , Anzoua Kossonou G. , Bagmet Larisa , Chebukin Pavel , Dwiyanti Maria S. , Dzyubenko Elena , Dzyubenko Nicolay , Ghimire Bimal Kumar , Jin Xiaoli , Jørgensen Uffe , Kjeldsen Jens Bonderup , Nagano Hironori , Peng Junhua , Petersen Karen Koefoed , Sabitov Andrey , Seong Eun Soo , Yamada Toshihiko , Yoo Ji Hye , Yu Chang Yeon , Zhao Hua , Jarquin Diego , Sacks Erik , Lipka Alexander E. 
Published: December 2023

AbstractMiscanthus is a genus of perennial grasses native to East Asia that shows promise as a biofuel energy source. Breeding efforts for increasing biofuel capability in this genus have focused on two species, namely M. sinensis (Msi) and M. sacchariflorus (Msa). For these efforts to succeed, it is critical that both Msi and Msa, as well as their interspecific crosses, can be grown at a wide range of latitudes. Therefore, the purpose of this study was to investigate how well existing data from Msi and Msa trials grown at locations throughout the northern hemisphere can train state‐of‐the‐art genomic selection (GS) models to predict genomic estimated breeding values (GEBVs) of dry yield for untested Msi and Msa accessions in untested environments. We found that accounting for genotype by environment interaction in the GS model did not notably improve predictive ability. Additionally, we observed that locations at lower latitudes showed higher predictive ability relative to locations at higher latitudes. These results suggest that it is crucial to increase the number of trial locations at higher latitude locations to investigate the source of this correlation. This will make it possible to train GS models using data from environments that are similar to growing conditions at the locations targeted by Msi and Msa breeders. Such an increase of trial locations in target environments could pave the way toward advancing breeding efforts for overwintering ability in Msi and Msa, and ultimately support the potential of Miscanthus as a biofuel crop.
The value of qualitative longitudinal research for researchers and policy‐makers: Lessons learnt from exploring long‐term impacts of flooding
Authors: Philip Lorna J. , Currie Margaret , Lyon Gillian 
Published: December 2023

AbstractThis paper offers reflections about the use of a longitudinal qualitative research design in a project which explored the long term impacts of flooding in two communities in North‐East Scotland. A temporal turn in the social sciences has raised the profile of longitudinal qualitative approaches, research whose diachronic framing allows trajectories and nuanced understandings of change to emerge. With reference to research which utilised a planned prospective longitudinal design, we offer reflections on methodological and project management ‘lessons learnt’ from undertaking a longitudinal qualitative study. Our experiences highlighted the importance of: (i) participant recruitment processes, including a need to ‘oversample’ to accommodate anticipated attrition rates; (ii) developing and sustaining a relationship between participants and researchers; (iii) reporting interim findings to participants, the funder and flood risk management stakeholders via a project Steering Group in particular; and (iv) agreeing a regular reporting schedule which allowed the funder and stakeholders access to findings during the lifetime of the project which, in turn, allowed impact to be generated before the final report was presented. In sharing our experiences our intention is twofold: to open a debate in human geography about how longitudinal qualitative research could be used more widely, in natural hazards research, rural community change and other research areas; and to illustrate that longitudinal qualitative research generates insights that can contribute to evidence‐based policy development, implementation and evaluation.