bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global tests in patients with Ph-negative myeloproliferative neoplasms
Authors: Silina N. N. , Korsakova N. E. , Golovina O. G. , Matvienko O. U. , Tarkovskaya L. R. , Efremova E. V. , Voloshin S V. 
Published: November 2023

Introduction: A frequent clinical manifestation of Ph-negative myeloproliferative neoplasms (MPN) is the development of thrombosis. To identify the state of hypercoagulation it is relevant and promising to introduce global tests for evaluating the hemostasis — the thrombin generation test (TGT) and thromboelastography (TEG). Aim: to evaluate the parameters of thrombin generation and thromboelastography in patients with Ph-negative MPN. Material and methods. In total, 62 patients with MNP were included in the study: 27 with polycythemia vera (PV), 14 with essential thrombocythemia (ET) and 21 with primary myelofibrosis (PMF). The control group included 55 practically healthy individuals, comparable in gender and age (19 people in the study of TEG, 36 people in the study of TGT). The TEG was performed using a “TEG 5000” thromboelastograph. TGT was measured with Calibrated Automated Thrombinography. Results: Ly30 and Ly60 in TEG in patients were significantly lower (0.35 (0.20–0.48), 0.00 (0.00–0.40) and 0.00 (0.00 — 0.43) and 3.15 (2.45–3.60), 1.25 (0.10–3.58) and 0.60 (0.00–3.05) respectively), than in the control (1.60 (1.05–2.75) and 6.20 (4.15–8.30), respectively), which indicates the ineffectiveness of fibrinolysis. The values of MA and G in patients with ET and PV significantly exceeded the control (69.15 (67.98–70.78) mm and 65.20 (59.65–63.83) mm versus 62.00 (57.75–6.75) mm and 11.20 (10.60–12.15) din/cm2 and 9.40 (7.40–11.60) din/cm2 versus 8.20 (6.85–8.75) din/cm2, respectively. The most pronounced change in sensitivity to TM was observed in patients with ET (27.94 (17.35–43.58) % and 13.29 (-3.48–23.60) %, respectively; p < 0.05). A significant decrease in ETP was observed in patients with PV and PMF. Conclusion. The study of hemostasis in patients with MPN using TEG and TGT revealed the presence of multidirectional changes associated with the disease. The TEG showed that an increase in the time required for the onset of fibrin formation is combined with increased clot strength and inhibited fibrinolysis, which are risk factors for the development of thromboembolic complications. The study of TGT determined a decrease in the quantitative characteristics of thrombin generation and at the same time the failure of the anticoagulant system of protein C, leading to the development of hypercoagulation.
(أثر أسلوب طاولة روبين في تحصيل تلميذات الصف الخامس الابتدائي في مادة العلوم)
Authors: زينب ثائر محمد  , أ.م.د كفاح محسن عبد الله  
Published: November 2023

يهدف البحث إلى لتعرف على أثر أسلوب طاولة روبين في تحصيل تلميذات الصف الخامس الابتدائي في مادة العلوم؛ ولتحقيق هدف البحث وفرضية اعتمدت الباحثتان تصميماً تجريبياً يقع في حقل التصاميم التجريبية ذات الضبط الجزئي للاختبار البعدي في تحصيل تلميذات الصف الخامس الابتدائي لمجموعتي البحث (التجريبية والضابطة). تمثل مجتمع البحث الحالي بتلميذات الصف الخامس الابتدائي في المدارس الثانوية والإعدادية للبنات الصباحية التابعة لمديرية العامة لتربية الصويرة للعام الدراسي (2022 – 2023)م، وبالاختيار القصدي اختيرت (انوار الزهراء للبنات) من بين مدارس المجتمع الحالي، وأجرت الباحثتان تكافؤاً بين تلميذات مجموعتي البحث في المتغيّرات الآتية: (درجات التحصيل للعام الدراسي السابق في مادة العلوم، اختبار المعلومات السابقة، اختبار الذكاء)، وللتحقق من هدف البحث أعدت الباحثتان أداة للبحث، إذ تمثلت باختبار التحصيلي في مادة العلوم من نوع الاختيار من متعدد، تكون من (30) فقرة وتم التأكد من صدقه ومستوى صعوبة فقراته، وقوة تمييزها، وفاعلية البدائل الخاطئة للفقرات، والتأكد من ثباتة باستخدام طريقة التجزئة النصفية، استعملت الباحثتان الوسائل الإحصائية المناسبة، وبعد تحليل النتائج إحصائياً توصلت الباحثتان إلى تفوق تلميذات المجموعة التجريبية على تلميذات المجموعة الضابطة بالطريقة الاعتيادية في اختبار التحصيل، وأوصت الباحثتان بعدد من التوصيات والمقترحات التي تم ذكرها في الفصل الرابع.
Konflik Hukum di Sektor Pertambangan: Perspektif Pengelolaan Sumber Daya Alam yang Berkelanjutan
Authors: Zulkarnain Zulkarnain 
Published: November 2023

Sustainable management of natural resources is one of the major challenges faced by Indonesia, one sector that is often a source of conflict is the mining sector. The purpose of this study is to analyze the factors that cause legal conflicts in the mining sector in Indonesia and examine the implications of legal conflicts for sustainable natural resource management. This research uses qualitative research methods. Data collection techniques in this research using literature studies. The data that has been collected is then analyzed using three stages, namely data reduction, data presentation and conclusion drawing. The results showed that legal conflicts in the mining sector in Indonesia were caused by several factors, including unfair profit sharing, environmental damage, and violations of community rights. Legal conflicts in the mining sector have negative implications for sustainable natural resource management. Legal conflicts can hamper investment, reduce productivity, and damage the environment.
Terapias Farmacológicas para o Tratamento da Dor Neuropática: Uma Análise Integrativa
Authors: Simões Montefuscolo Bheatriz , Leão França Débora , Cavaco Gonçalves Pereira Isabella , Polachini da Silva Amanda Augusta , Barrancos Barbosa Mello José Victor 
Published: November 2023

A dor neuropática representa um desafio significativo na prática clínica devido à sua complexidade e impacto na qualidade de vida dos pacientes. Neste contexto, diversas terapias farmacológicas têm sido exploradas como estratégias para aliviar os sintomas associados a essa condição. A presente análise integrativa busca examinar e consolidar as evidências científicas disponíveis sobre as terapias farmacológicas utilizadas no tratamento da dor neuropática, oferecendo uma visão abrangente do atual panorama terapêutico.
Dentre as abordagens farmacológicas, destaca-se a pesquisa sobre inibidores de histona deacetilases (HDACs) e inibidores de bromodominio 4 (BRD4), evidenciando sua promissora eficácia no alívio da dor neuropática ao modular a resposta inflamatória em células microgliais. Além disso, a análise também abrange os avanços recentes no uso de agentes que interferem no sistema renina-angiotensina para prevenir a neuropatia periférica induzida por quimioterapia, destacando a importância dessas intervenções inovadoras no manejo da dor neuropática associada a tratamentos oncológicos.
A compreensão mais profunda das estratégias farmacológicas para a dor neuropática, abordando desde os mecanismos moleculares até os resultados clínicos, proporciona insights valiosos para os profissionais de saúde na escolha de abordagens terapêuticas personalizadas. Esta análise integrativa busca, assim, contribuir para o desenvolvimento de abordagens mais eficazes e abrangentes no tratamento dessa condição desafiadora, destacando o papel crucial das terapias farmacológicas na gestão da dor neuropática e seus potenciais impactos positivos na qualidade de vida dos pacientes.
Avaliação de Técnicas Cirúrgicas na Ressecção de Tumores Colorretais: uma revisão abrangente
Authors: Camargo do Carmo Edilayne , Lopes de Azevedo Renzo , Andrade Ana Carolina , Salmen Eller Miranda Calebe , Teodoro da Cunha Jardim Samara Roberta 
Published: November 2023

Os tumores colorretais englobam cânceres que afetam o cólon ou o reto, sendo notáveis pela sua prevalência global e impacto significativo na saúde, sendo a ressecção cirúrgica uma abordagem fundamental no tratamento desses tumores, visando remover as áreas afetadas e potencialmente curar a doença. Diversas técnicas cirúrgicas são exploradas, desde abordagens tradicionais, como a ressecção convencional, até procedimentos mais recentes, como a cirurgia laparoscópica e robótica. A escolha da técnica cirúrgica apropriada é crucial para otimizar os resultados clínicos e a qualidade de vida pós-operatória dos pacientes.
Alguns estudos abordam as potenciais diferenças fisiopatológicas entre as duas técnicas anastomóticas. Acredita-se que a EA esteja associada a um trauma cirúrgico mais significativo, devido a incisões cutâneas mais longas necessárias para acessar manualmente o intestino. A realização da EA em um ambiente extrabdominal também pode contribuir para uma maior tração no mesentério, aumentando o risco de lesões serosas e sangramento intraoperatório, o que pode prejudicar a recuperação pós-operatória e aumentar as taxas de morbidade.
A escolha da técnica cirúrgica adequada é crucial para alcançar resultados clínicos favoráveis e aprimorar a qualidade de vida dos pacientes. Além disso, ao identificar lacunas no conhecimento e áreas que demandam pesquisas adicionais, este trabalho contribui para o avanço contínuo na área, promovendo o desenvolvimento de estratégias terapêuticas mais eficazes. O presente estudo tem como objetivo investigar as técnicas mais utilizadas para ressecção de tumores colorretais, assim como sua eficácia e complicações.
Predicting Quality of life of Schizophrenia Patients
Authors: Insiyah Insiyah , Rohimah Yeni Tutu , Astuti Sri Lestari Dwi , Lestari Siti , Suyanto Suyanto , Sulistyowati Endang Caturini 
Published: November 2023

Background: Previous studies on sociodemographic characteristics connected to quality of life in schizophrenia discovered inconsistent results. This study aims to analyze predicting factors of quality of life (QoL) of schizophrenia patients.
Methods: A quantitative study included 153 respondents who were selected using random sampling at the State Psychiatric Hospital Surakarta. The research instruments were a questionnaire containing questions about demographics consisting of age, age at first experiencing schizophrenia, gender, education level, work status, marital status, frequency of treatment, duration of suffering from schizophrenia, insight, physical health problems and quality of life by using WHOQOL-BREF. The analyses used were Spearmen's rank (rho) and the Pearson Chi-Square to analyze factors connected to QoL of schizophrenia patients and multiple logistic regression tests to analyze predictors of QoL of schizophrenia patients. This study was conducted in the State Psychiatric Hospital of Surakarta from September 2020 to March 2021.
Results: There were 4 characteristics of sociodemographic that have a positive significant relationship with the overall quality of life of schizophrenia patient, namely work status (p = 0.000), marital status with p = 0.000, gender (p=0.032), and adherence to take medicine with p=0.015 (p <0.05). marital status and work status that influence the quality of life (p=0.000 and p=0.001). Marital status and work status influence the quality of life (p=0.000 and p=0.001), the largest OR value obtained is 25.499. It means that married patients have a 25.499 times chance of having a better quality of life controlled by work status.
Conclusion: Marital status and work status are predictors of QoL of schizophrenia. In providing services to schizophrenic patients, health professional need to pay attention in assessing social demographics such as work status and marital status so that appropriate action can be taken with an approach to these aspects.
Transgender health is a vital component in healthcare
Authors: Sethi Divya , Kiran Swosti , Pal Debkumar , Sahoo Bimal Kumar , Taywade Manish 
Published: November 2023

Abstract
The term “transgender” is used to describe individuals whose innate sense of one’s own gender, expression or behavior is not in alignment with the sociocultural expectations emerging from the gender assigned to them at birth, legally and medically. The term encompasses such a wide spectrum of gender identities and expressions that it has not been possible to completely understand the dynamics of a “transgender” individual’s experiences. A transgender faces injustice and discrimination at every turn in life. They are victims of sexual abuse, violence, social stigma and harassment, intense poverty, substance abuse, and overall poor physical and mental health. A transgender has both routine healthcare needs like the rest of the population and unique healthcare needs such as gender-affirming hormone therapy and surgeries. A transgender-friendly healthcare system with healthcare staff competent in knowledge and interest in transgender care is the need of the hour to address the health concerns of this population.
Seroprevalence of Coxiella burnetii in an Indigenous Population from the Sierra Nevada De Santa Marta, Colombia
Authors: Oakley Regina , Dreyfus Anou , Concha Gustavo , Poppert Sven , Plag Michèle , Meile Celine , Graves Stephen , Paris Daniel H. , Kann Simone 
Published: November 2023

ABSTRACT.
Coxiella burnetii is an underreported zoonotic pathogen in many rural regions globally. We investigated C. burnetii exposure in a remote indigenous tribe residing in the Sierra Nevada de Santa Marta, Colombia. The high seroprevalence of 35% (95% CI, 27–43%) demonstrates the need for One Health studies to identify risk factors, clinical impact, and potential medical, veterinary, and environmental interventions.
Effectivity of Mobile Health as Progressive Muscle Relaxation Training Media to Premenstrual Symptoms in Adolescents
Authors: Dewi Marfuah  , Dewi Srinatania  , Nunung Nurhayati  , Nuraini Fauziah  
Published: November 2023

Premenstrual syndrome (PMS) is a disease characterized by mood or emotional, bodily, and behavioral symptoms of reproductive women that increase in the menstrual cycle during the luteal phase and disappear within a few days after menstruation. Approximately 50% - 80% of reproductive women suffer from PMS (approximately 3% to 8%) can cause severe mood swings, which interfere with their lifestyle and quality of life. Progressive Muscle Relaxation (PMR) is an effective way to achieve a balance between the sympathetic and the parasympathetic nervous system so reducing the impact of stress on the body. This study aim to evaluate effectivity of progressive muscle relaxation by mobile health to premenstrual syndrome in adolescent. A quantitative study using a Quasy-experimental with two Group Pre-Posttest design. Samples are 52 adolescents have experience PMS, have reguler menstrual cycle, are able to communicate well, can read and write, have cellphones/other communication tools, and willing be a respondent. Instruments using PSST for Screening of PMS and DRSP for evaluate PMS at experimental and control groups. Experimental Group given PMR by mobile health during 10 days. Bivariat analysis using Mann-Whitney test. The result of study found that grade of PMS at pretest was 15% mild, 38,5% Moderate and Severe among 48,5%. The Mann-Whitney value showed that there was a significant difference found between experimental and control group at level of p <0,001. This is reveals that there was a significant decrease to premenstrual syndrome in the experimental group after PMR. This study showed that there is a strong need for further reproductive health education. So there should be a regular service and health education programme on premenstrual syndrome and progressive muscle relaxation or exercises at all hospitals or clinic and nurses or another caregivers have an important role to do it.
PENGARUH GAYA KEPEMIMPINAN TERHADAP SEMANGAT KERJA PEGAWAI PADA KANTOR DINAS PENDIDIKAN OKU TIMUR
Authors: Subarjono Subarjono , Kurniawan Deni , Sahlan Sahlan , Solikhan Solikhan 
Published: November 2023

Suatu organisasi akan berhasil atau gagal yang sebagian besar ditentukan oleh pemimpin. Hal ini dapat dilihat bagaimana seorang pemimpin dalam bersikap dan bertindak. Salah satu unsur penting kepemimpinan dalam kaitannya terhadap semangat kerja adalah gaya kepemimpinan. Gaya kepemimpinan adalah cara seorang pemimpin mempengaruhi perilaku bawahan, agar mau bekerja sama dan bekerja secara produktif untuk mencapai tujuan organisasi. Semangat kerja yang tinggi bisa dilihat dari jumlah presensi, kerja sama yang baik, dan hubungan yang harmonis. Permasalahan yang dihadapi Kantor Dinas Pendidikan OKU Timur adalah bagaimana pengaruh gaya kepemimpinan terhadap semangat kerja pegawai, sedangkan tujuan penelitian ini adalah untuk menganalisis dan membuktikan pengaruh gaya kepemimpinan terhadap semangat kerja pegawai pada Kantor Dinas Pendidikan OKU Timur. Hipotesis yang diajukan adalah Adanya hubungan yang kuat antara gaya kepemimpinan terhadap semangat kerja pegawai pada Kantor Dinas Pendidikan OKU Timur. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi, dokumentasi, dan kuisioner serta studi kepustakaan. Dari hasil perhitungan diperoleh hasil angka r = 0,249. setelah dikonsultasikan dengan standar konservatif ternyata 0,249 terletak antara 0,200 – 0,399 yang termasuk pada korelasi rendah. Kemudian untuk menjawab uji hipotesis yang diajukan pada bab sebelumnya mempunyai hubungan atau tidak, maka di uji dengan uji hipotesa dan didapat to = 0,704 maka apabila dihubungkan dengan t nilai pada tingkat kepercayaan 0,95 yang berarti tingkat kesalahannya 0,05 adalah t hitung lebih kecil dari t tabel (0,704 lebih kecil dari 1,860), maka hipotesis yang diajukan adalah TIDAK TERBUKTI yaitu menolak hipotesis alternatif ( Ha ) dan menerima hipotesis nol (Ho).
relação professor formador e professor estagiário: uma reflexão sobre afetos e poder de agir
Authors: Lopes Wescley Batista , Clemente Marina Cavalcanti Tavares , Moraes Rozania Maria Alves de 
Published: November 2023

O presente artigo tem o objetivo de investigar como os afetos gerados por professores formadores podem interferir na ampliação do poder de agir de professores em formação inicial. Para tanto, realizamos um estudo junto aos alunos do curso de Letras (língua português/francês), da Universidade Estadual do Ceará (UECE). O corpus analisado neste artigo é composto por respostas apresentadas por nossos sujeitos de pesquisa a um questionário elaborado pelos autores deste estudo. A fim de analisarmos o discurso dos discentes e de compreendermos as relações dialógicas estabelecidas, recorremos aos estudos da linguagem de Bakhtin e o Círculo (Bakhtin, 2011) e à Teoria dos Afetos (Spinoza, 2019). Em nossos resultados, foi possível concluir que, embora as questões relacionadas aos afetos não representem um tema recorrente na formação inicial dos professores do curso de Letras, a relação de alteridade estabelecida entre o professor formador e os formandos é um ato inquestionável. Além disso, observamos que os afetos estabelecidos nessa relação podem servir de alargadores das potencialidades e do poder de agir dos futuros profissionais; por isso, devem ser objeto de maior reflexão na formação inicial.
Abuse of tapentadol compared to other atypical opioids among individuals entering treatment for opioid use disorders
Authors: Severtson S. Geoff , Gurrola Marie C. , Parrino Mark W. , Ellis Matthew S. , Cicero Theodore J. , Iwanicki Janetta L. , Dart Richard C. 
Published: November 2023

Objective: Tapentadol is an atypical opioid analgesic thought to have dual mechanisms of action: μ-receptor agonism and inhibition of norepinephrine reuptake. Unlike other atypical opioids, tapentadol is a schedule II-controlled substance. We compared the prevalence of abuse (use to get high) of tapentadol to other atypical opioids used to treat pain (buprenorphine and tramadol).
Design: An observational, serial cross-sectional study.
Setting: Individuals enrolling in treatment programs for opioid use disorder in 2019. Each completed a self-administered, paper questionnaire assessing prescription drug abuse and illegal drug use within 1 week of enrollment.
Main outcome measures: Indication of past month abuse of tapentadol or comparator drugs on a self-administered questionnaire.
Results: There were 6,987 respondents. Unadjusted and utilization-adjusted logistic regression models were used to compare odds of endorsement of tapentadol to tramadol and buprenorphine products indicated for the management of pain. Unadjusted abuse prevalence was 0.20 percent for total tapentadol (0.03 percent for NUCYNTA® and 0.06 percent for NUCYNTA ER). Relative to total tapentadol, the odds of abuse of buprenorphine for pain was 2.9 times greater (95 percent CI: 1.6 to 5.3, p < 0.001), and for tramadol, 43.1 times greater (95 percent CI: 25.3 to 73.3, p < 0.001). Adjusting for prescriptions dispensed, differences in odds of abuse were not statistically significant (odds ratio (OR) = 1.6, 95 percent CI: 0.9 to 3.0, p = 0.108 for buprenorphine for pain and OR = 0.7, 95 percent CI: 0.4 to 1.2, p = 0.209 for tramadol).
Conclusions: Tapentadol use to get high is less frequent than other atypical opioids. Findings suggest tapentadol is rarely the primary drug abused by an individual.
USO DA CURCUMA LONGA LINN NO TRATAMENTO DA ARTRITE REUMATOIDE
Authors: Santos Vítor Emanuel Andrade dos , Carvalho Ana Vitória Soares da Silva , Rodrigues Maria Eduarda Santos , Moreira Maria Eduarda Silva , Metzker Cristiane 
Published: November 2023

A artrite reumatoide (AR) é uma doença autoimune crônica e progressiva caracterizada por inflamação persistente nas articulações periféricas. Sua etiologia é complexa, envolvendo fatores genéticos, ambientais, hormonais e manifestações extra intestinais. A doença causa inflamação simétrica nas articulações, especialmente nas mãos e nos pés, levando à tumefação, edema, dor e, se não tratada adequadamente, à destruição permanente das articulações. A AR afeta aproximadamente 0,5% a 1% da população e tem um impacto significativo na qualidade de vida e na economia. O tratamento da AR envolve educação do paciente, medicamentos, fisioterapia, apoio psicossocial, terapia ocupacional e, em alguns casos, cirurgias. Com o avanço da tecnologia, novas abordagens terapêuticas têm sido desenvolvidas para controlar a doença, incluindo o uso de fitoterapia. A Curcuma longa, também conhecida como cúrcuma, tem sido estudada devido às suas propriedades anti-inflamatórias e antioxidantes. Originária do Sudeste Asiático, a cúrcuma é utilizada como tempero, corante e na medicina tradicional.
O tratamento da AR envolve educação do paciente, medicamentos, fisioterapia, apoio psicossocial, terapia ocupacional e, em alguns casos, cirurgias. Com o avanço da tecnologia, novas abordagens terapêuticas têm sido desenvolvidas para controlar a doença, incluindo o uso de fitoterapia. A Curcuma longa, também conhecida como cúrcuma, tem sido estudada devido às suas propriedades anti-inflamatórias e antioxidantes. Originária do Sudeste Asiático, a cúrcuma é utilizada como tempero, corante e na medicina tradicional.
Palavras-chave: Artrite reumatoide, inflamação articular, fitoterapia, Curcuma longa, tratamento adjuvante.
ATUAÇÃO DO CIRURGIÃO DENTISTA DENTRO DO AMBIENTE HOSPITALAR: AMPLIAÇÃO DA QUALIDADE DE VIDA DOS USUÁRIOS NO BRASIL APÓS 2004
Authors: Moreira Sabrina Alves , Santos Fabrício 
Published: November 2023

O presente artigo aborda sobre a atuação do Cirurgião Dentista dentro do ambiente hospitalar, pautando na ampliação da qualidade de vida dos usuários no Brasil, após 2004. Visto que, a negligência com a saúde bucal dos pacientes hospitalizados acarretará danos na saúde geral do mesmo, dessa forma prorrogando o tempo de internação. Assim, a problemática desse trabalho consiste em: Como o cirurgião dentista pode atuar na qualidade de vida dos usuários de serviços hospitalares? E com o objetivo geral de conhecer as atividades realizada pelo cirurgião dentista no ambiente hospitalar para ampliação da qualidade do serviço. Nesse viés, os objetivos específicos consistem em contextualizar a importância do Cirurgião Dentista no ambiente hospitalar, levantar estudos que apontam a relação entre as doenças bucais e a condição sistêmica dos pacientes hospitalizados e apresentar os principais problemas enfrentados na rotina do Cirurgião Dentista em hospitais. A metodologia adotada baseia-se em uma revisão bibliográfica de artigos científicos e livros relevantes e com abordagem qualitativa. Por fim, com os resultados desse estudo torna-se evidente a importância da atuação do Cirurgião Dentista junto à equipe multidisciplinar dentro do ambiente hospitalar através dos cuidados com a saúde bucal, contribuindo efetivamente para a melhoria do quadro clínico dos pacientes.