bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of non-invasive brain stimulation on cancer-related pain: evidence from meta-analyses of randomized controlled trials
Authors: Zhang Yaqi , He Xiuyun , Gong Chen , Wang Yafei , You Longfei , Lin Yangyang , Wang Yuling , Feng Beibei 
Published: January 2025

Abstract

Purpose
Cancer-related pain (CRP) is one of the most challenging disorders among cancer survivors. Non-invasive brain stimulation (NIBS) is an emerging technique for alleviating pain. Although there is evidence suggesting that NIBS can alleviate CRP, higher level evidence is still required to further substantiate its efficacy and safety. This study aimed to evaluate the efficacy of NIBS interventions for CRP via a meta-analysis.

Methods
Databases such as MEDLINE, PubMed, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, China National Knowledge Infrastructure were systematically searched using key terms related to pain, cancer, and NIBS. The primary outcome was pain intensity and the secondary outcome was depression. After extracting and assessing data from the included literature, we performed Meta-analysis using RevMan 5.4.1 software.

Results
The results encompassed 11 randomized controlled trials papers, involving 714 patients. The Meta-analysis findings indicated that NIBS demonstrated a significant reduction in pain intensity scores {SMD −0.72 [95% confidence interval (CI), −1.00 to −0.43], P &lt; 0.00001}. NIBS also had a notable effect on depression [SMD −0.62 (95% CI, −0.93 to −0.31), P = 0.0004]. However, subgroup analysis revealed that one single session of NIBS did not show statistical significance in analgesic effect. Furthermore, no matter targeting the M1 and DLPFC areas, as well as using either rTMS or tDCS, resulted in significant reductions in pain intensity.

Conclusion
NIBS exhibited a promising trend in alleviating CRP and enhancing treatment effectiveness. Nonetheless, due to limitations in the quantity and quality of the included studies, these findings warrant further validation through additional research.
Effects of Credit Expansions on Stock Market Booms and Busts
Authors: Hansman Christopher , Hong Harrison , Jiang Wenxi , Liu Yu-Jane , Meng Juan-Juan 
Published: January 2025

Abstract
There is causal evidence that mortgage credit expansions increase house prices. Does an expansion of margin lending increase stock prices? Because unconstrained arbitrageurs are more important for pricing stocks than homes, the impact is not obvious. Tests are limited because sizable shocks to margin lending are rare. We examine a major Chinese margin-lending expansion between 2010 and 2015. Institutional holding, regression discontinuity, and event study evidence—exploiting the rollout of margin lending across stocks—shows that arbitrageurs anticipated and bought in advance of a significant causal effect of credit. We develop a model to rationalize our findings. Our estimates suggest that margin debt contributes to stock market fluctuations.
Increased default mode network activation in depression and social anxiety during upward social comparison
Authors: Acuña Alejo , Morales Sebastián , Uriarte-Gaspari Laura , Aguirre Nara , Brandani Antonella , Huart Natalia , Mattos Javier , Pérez Alfonso , Cuña Enrique , Waiter Gordon , Steele Douglas , Armony Jorge L , García-Fontes Margarita , Cabana Álvaro , Gradin Victoria B 
Published: January 2025

Abstract
Social comparisons are a core feature of human life. Theories posit that social comparisons play a critical role in depression and social anxiety triggering negative evaluations about the self, as well as negative emotions. We investigated the neural basis of social comparisons in participants with major depression and/or social anxiety (MD-SA, n = 56) and healthy controls (n = 47) using functional magnetic resonance imaging. While being scanned participants performed a social comparison task, during which they received feedback about their performance and the performance of a coplayer. Upward social comparisons (being worse than the coplayer) elicited high levels of negative emotions (shame, guilt, and nervousness) across participants, with this effect being enhanced in the MD-SA group. Notably, during upward comparison the MD-SA group showed greater activation than the control group in regions of the default mode network (DMN). Specifically, for upward comparison MD-SA participants demonstrated increased activation in the dorsomedial prefrontal cortex and reduced deactivation in the posteromedial cortex, regions linked to self-referential processing, inferences about other people’s thoughts, and rumination. Findings suggest that people with depression and social anxiety react to upward comparisons with a more negative emotional response, which may be linked to introspective processes related to the DMN.
Dexmedetomidine plays a protective role in sepsis-associated myocardial injury by repressing PRMT5-mediated ferroptosis
Authors: Wang Dan , Wang Jun , Yang Li , Wang Xin , Huang Sijian 
Published: January 2025

Abstract
Sepsis rapidly contributed to multiorgan failure, most typically damaging the cardiovascular system, and there were no effective treatments. Dexmedetomidine (Dex) has good therapeutic effects on sepsis-induced organ injury. Our work aimed to probe the pharmacological effects of Dex on ferroptosis in sepsis-associated myocardial injury (S-MI) and define underlying mechanism of action. Cardiomyocytes were exposed to lipopolysaccharide (LPS) for mimicking S-MI model in vitro. The septic mice were constructed by cecum ligation and puncture operation. The mRNA and protein expressions were assessed using quantitative real-time polymerase chain reaction or western blot. Cell survival was determined by cell counting kit-8, lactic dehydrogenase release, and flow cytometry assays. 2′,7’-Dichlorodihydrofluorescein diacetate staining measured cellular reactive oxygen species level. The secretion levels of inflammatory cytokines, ferroptosis-related indicators were analyzed by enzyme-linked immunosorbent assay. The N6-methyladenosine (m6A) modification level of protein arginine methyltransferase 5 (PRMT5) mRNA was examined by methylated RNA binding protein immunoprecipitation (Me-RIP) assay. The interaction between methyltransferase like 3 (METTL3)/fat mass and obesity-associated protein (FTO) and PRMT5 was analyzed by RNA immunoprecipitation assay. Dex treatment alleviated LPS-induced cardiomyocyte injury and ferroptosis, while these effects of Dex were reversed by Erastin treatment. Mechanically, Dex ameliorated PRMT5 expression in LPS-induced cardiomyocytes by regulating METTL3/FTO catalyzed m6A modification on PRMT5 mRNA. Rescue experiments confirmed that PRMT5 overexpression abolished Dex-mediated inhibitory roles on LPS-induced cardiomyocyte injury and ferroptosis. Moreover, Dex administration alleviated inflammation, ferroptosis, and myocardial injury in septic mice. Taken together, Dex repressed PMRT5 expression in a m6A-dependent manner, thus lightening LPS-triggered ferroptosis to alleviate cardiomyocyte injury.
Managing advanced pigmentary glaucoma when medical and laser treatment has failed
Authors: Larsen Christine L. , Nakatsuka Austin , Nguyen Bac , Yung Edward , Schehlein Emily , Van Tassel Sarah H. , Kamat Shivani , Havens Shane 
Published: January 2025

A 50-year-old dentist was referred for management of advanced pigmentary glaucoma in his left eye. He reported onset of blurring in the left eye approximately 9 months ago, when he was found to have intraocular pressure (IOP) in the 40s. He presented on maximum topical medical therapy to include fixed combination netarsudil + latanoprost, brimonidine + brinzolamide, and timolol in the left eye. He used latanoprost alone in the right eye. The referring ophthalmologist had performed selective laser trabeculoplasty (SLT) 3 months earlier, which was deemed ineffective. Ocular history was notable for moderate myopia and long-term contact lens wear; the patient stated he required contact lenses underneath his procedural loupes for work purposes. Medical history and medication use was otherwise unremarkable.
Examination revealed a corrected distance visual acuity (CDVA) of 20/25. A relatively afferent pupillary defect was found in the left eye. The IOP was 18 mm Hg in the right eye and 30 mm Hg in the left eye in the setting of mean pachymetry at 552 and 548 in the right and left eyes, respectively. The patient displayed classic findings of pigment dispersion, including Krukenberg spindles in both eyes and midperipheral iris transillumination defects in the left eye. Gonioscopy revealed open angles in both eyes with dense trabecular meshwork pigment. Posterior bowing of the iris near the insertion was evident in both eyes but more dramatic in appearance in the left. This finding was demonstrated on anterior segment imaging (Figures 1 and 2

JOURNAL/jcrsoc/04.03/02158035-202501000-00012/figure1/v/2025-01-30T210536Z/r/image-tiff

JOURNAL/jcrsoc/04.03/02158035-202501000-00012/figure2/v/2025-01-30T210536Z/r/image-tiff

). Lenses were clear, and the fundus examination was otherwise unremarkable except for an enlarged cup-to-disc ratio of 0.7 in the right eye and a near total cup with diffusely thin neuroretinal rim in the left. Optical coherence tomography of the nerve fiber layer and retinal ganglion cell layer was received from the referring provider. It was normal in the right eye and showed diffuse thinning of both scans in the left. A visual field was also normal in the right eye. The 24-2 visual field in the left eye showed a central island, and subsequent 10-2 testing demonstrated similar dense constriction (Figure 3

JOURNAL/jcrsoc/04.03/02158035-202501000-00012/figure3/v/2025-01-30T210536Z/r/image-tiff

).
Please comment on your management of the patient's left eye.
The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective
Authors: Huong Nguyen Xuan , Harrison Michelle , Kasahara Erena , Marais Ben , Putri Nina Dwi , Williams Phoebe CM 
Published: January 2025

Purpose of review
The densely populated Asia Pacific region is home to 600 million children, and suffers from a significant burden of morbidity and mortality due to infections associated with antimicrobial resistance (AMR). We aimed to identify the drivers, challenges and potential opportunities to alter the burden of AMR within the region.

Recent findings
Despite the high AMR burden borne by the Asia Pacific region, there are limited (and geographically imbalanced) published data to delineate the contemporary epidemiology of serious multidrug-resistant bacterial infections in children. Furthermore, the region is impacted by overcrowded and poorly resourced healthcare facilities, insufficient microbiological resources, and widespread community and environmental antibiotic use leading to limited efficacy for frequently prescribed antibiotics. Vaccine coverage is also inadequate and inequitable, further driving the burden of infectious disease (and antibiotic overuse) in children.

Summary of implications
There are many challenges in implementing antimicrobial stewardship and infection prevention and control programs to reduce the excessive AMR disease burden in children across the Asia Pacific region, yet locally-driven strategies have successfully reduced antibiotic overuse in some settings, and should be replicated. Reducing the AMR disease burden will require improved healthcare resourcing, including better access to microbiological diagnosis, and multidisciplinary approaches to enhance infection prevention and antibiotic prescribing.
Transforming RN-Baccalaureate Education Using Insights From a National Faculty Needs Assessment
Authors: Heywood Natalie , Williams Rhonda , Blackwell Deborah , Hommes Tiffany , Franklin Sherri , Nichols Lynn Stover 
Published: January 2025

Background:
The recent American Association of Colleges of Nursing (AACN) Essentials revision emphasizes direct clinical experiences across 4 spheres of care in RN-Baccalaureate (RN-B) education, creating challenges for online, asynchronous programs. Differentiating between prelicensure and postlicensure education complicates the integration of these requirements. Understanding RN-B faculty needs is critical for curricular transformation.

Purpose:
This needs assessment examines challenges faced by RN-B faculty in integrating the AACN Essentials into nursing curricula and provides resources critical for the transition to them.

Methods:
A web-based needs assessment was conducted with RN-B faculty across the United States. It included a demographic questionnaire, 5 quantitative questions, and 3 qualitative items.

Results:
The assessment revealed a need for enhanced academic support, resources, communication, and collaboration to facilitate implementation.

Conclusion:
This article offers insights, recommendations, and resources for RN-B faculty engaged in curricular transformation, emphasizing targeted support for adopting the AACN Essentials.
Analysis of Timely Follow-Up in the Evaluation of Postmenopausal Bleeding
Authors: Atkins Sage , Nolin Angela , Unnithan Shakthi , Myers Evan R. , Kruse Danielle E. , Erkanli Alaattin , Havrilesky Laura J. 
Published: January 2025

OBJECTIVE:
To characterize guideline-adherent follow-up in patients evaluated with transvaginal ultrasonography (TVUS) for postmenopausal bleeding.

METHODS:
We conducted a retrospective study of patients with an intact uterus and postmenopausal bleeding who presented to a single academic institution and underwent TVUS between January 2013 and December 2022. Primary outcome measures were prompt follow-up, defined as receipt of endometrial sampling within 3 months of a finding of thickened or inadequately visualized endometrium, diagnosis of endometrial cancer, cancer stage at diagnosis, and rates of tissue sampling. Associations between sociodemographic variables and prompt follow-up were assessed. A Pareto analysis was performed to describe reasons for lack of prompt follow-up.

RESULTS:
Of 1,671 patients with thickened endometrium, 307 (18.4%) did not receive prompt follow-up; of 389 patients with inadequately visualized endometrium, 128 (33.0%) did not receive prompt follow-up. Sociodemographic variables were not associated with prompt follow-up. Clinician-related factors, including misinterpretation of ultrasound results, accounted for 46.1% of delayed or absent follow-up for thickened endometrium and 58.4% of inadequately visualized endometrium. The rates of diagnosing endometrial cancer within 1 year were similar after findings of thickened endometrium (8.8%; 95% CI, 7.5–10.3%) compared with inadequately visualized (7.7%; 95% CI, 5.3–10.9%) endometrium.

CONCLUSION:
Clinician misinterpretation of TVUS performed for postmenopausal bleeding was the most common reason for delayed or absent follow-up. Given observed suboptimal rates of prompt follow-up after findings of thickened or inadequately visualized endometrium on ultrasonography and similar rates of an eventual cancer diagnosis in these cohorts, efforts should be focused on clinician understanding of ultrasonographic endometrial evaluation. To simplify the diagnostic process and reduce the risk of missing a cancer diagnosis, universal endometrial sampling for patients with postmenopausal bleeding could be considered.
68Ga-FAPI-04 Versus 18F-FDG PET/CT in Duodenal Synovial Sarcoma
Authors: Zhan Fenglin , Liu Xin , Zhou Hangcheng , Wang Xuemei , Yao Xiaobo 
Published: January 2025

Abstract
A previously healthy 18-year-old man with a 9-month history of upper abdominal pain and significant weight loss underwent gastroscopy, revealing an ulcerative lesion in the duodenal bulb. Enrolled in a clinical trial, both 18F-FDG and 68Ga-FAPI-04 PET/CT demonstrated similar metabolic activity, though 68Ga-FAPI-04 offered superior lesion delineation. Pathology confirmed synovial sarcoma. This case highlights the potential utility of 68Ga-FAPI-04 as a radiopharmaceutical for evaluating rare gastrointestinal synovial sarcomas.
Swarm systems as a platform for open-ended evolutionary dynamics
Authors: Sayama Hiroki 
Published: January 2025

Artificial swarm systems have been extensively studied and used in computer science, robotics, engineering and other technological fields, primarily as a platform for implementing robust distributed systems to achieve pre-defined objectives. However, such swarm systems, especially heterogeneous ones, can also be utilized as an ideal platform for creating open-ended evolutionary dynamics that do not converge toward pre-defined goals but keep exploring diverse possibilities and generating novel outputs indefinitely. In this article, we review Swarm Chemistry and its variants as concrete sample cases to illustrate beneficial characteristics of heterogeneous swarm systems, including the cardinality leap of design spaces, multi-scale structures/behaviours and their diversity, and robust self-organization, self-repair and ecological interactions of emergent patterns, all of which serve as the driving forces for open-ended evolutionary processes. Applications to science, engineering and art/entertainment as well as the directions of further research are also discussed.
This article is part of the theme issue ‘The road forward with swarm systems’.
Swarm shepherding using bearing-only measurements
Authors: Li Aiyi , Ogura Masaki , Wakamiya Naoki 
Published: January 2025

Drawing inspiration from natural herding behaviours, shepherding provides a method for swarm guidance that utilizes steering agents and can be applied in biological and robotics systems at various scales. However, while most shepherding research has relied on the precise sensing capabilities of steering agents, these assumptions do not necessarily hold in real-world tasks. To fill in the gap between practice and literature, in this study, we demonstrate that swarm shepherding can be achieved via bearing-only measurements, and explore the minimum amount of information required. We initially formulate our algorithm for a single agent and subsequently expand its application to accommodate multiple agents, incorporating strategies tailored for herding multiple swarms. Numerical simulations show the effectiveness of the algorithm under various initial placements and configurations. The minimum amount of information required by the proposed algorithm for successful shepherding, i.e. a moderate angular accuracy for the steering agents and limited communication between them, is also determined. Our proposed bearing-only algorithm offers crucial insights into swarm dynamics, which may have applications across a variety of domains, such as agriculture and search and rescue.
This article is part of the theme issue ‘The road forward with swarm systems’.
Boecheraor not? Genomic insights and taxonomic reassessment of the misclassified Asian speciesB. calcarea(Brassicaceae)
Authors: Mandáková Terezie , Pouch Milan , Hloušková Petra , German Dmitry A. , Windham Michael D. , Trávníček Pavel , Lysak Martin A. 
Published: January 2025

ABSTRACTThe genusBoechera(Brassicaceae) serves as a model system for studying apomictic reproduction and ecological adaptations, with most species concentrated in North America. Rare occurrences ofBoecheraspecies beyond their typical range offers unique opportunities to investigate genome evolution in extralimital environments. One such species,B. calcarea, was described from the Chandalaz Range in northeastern Asia (Russia). This study aimed to investigate the genome structure and evolutionary history ofB. calcarea. However, our analyses reveal that the species does not belong toBoechera. Instead, an integrative approach combining cytogenetic, phylogenetic and repeatome analyses identified the species as a member of an ancestral clades within the tribe Arabideae. The diploidParryodes calcarea(Dudkin) D.A.German & Lysak (2n= 16) exhibits Arabideae-specific chromosomal signatures, including multiple centromere repositionings. These findings clarify the misattribution ofP. calcareatoBoechera, leavingBoechera falcataandBorodinia macrophyllaas the only Old World representatives of the Boechereae. This study highlights the importance of integrative methodologies in resolving taxonomic ambiguities and provides new insights into the diversification of the largest cruciferous tribe, Arabideae.
Transmissible antimicrobial resistance inEscherichia coliisolated from household drinking water in Ibadan, Nigeria
Authors: Rabiu Akeem G. , Falodun Olutayo I. , Dada Rotimi A. , Afolayan Ayorinde O. , Akinlabi Olabisi C. , Akande Elizabeth T. , Okeke Iruka N. 
Published: January 2025

AbstractContaminated household water in peri-urban urban communities is a reservoir for virulentEscherichia coli, but its role in the environmental transmission of antibiotic resistance genes (ARGs) remains poorly understood. This study characterizedE. colifrom household water and additionally aimed to investigate the transmissibility of ARGs from drug-resistant isolates. Twenty-fiveE. colifrom thirteen household well water sources were tested for resistance to 14 antibiotics by disc diffusion and whole-genome sequenced using the Illumina platform. The ARGs and plasmid replicon types were respectively predicted using ResFinder and PlasmidFinder. Multidrug-resistant strains carrying plasmid replicons found in unrelated strains were conjugated with nalidixic acid-resistant (NALR)E. coliC600using the solid plate method. Fifteen isolates displayed a multi-drug resistance (MDR) phenotype with 18 possessing ARGs that confer resistance to trimethoprim-sulfamethoxazole, macrolide, sulphonamide, aminoglycoside, chloramphenicol, β-lactams, and tetracycline. Fifteen of the 25 isolates belonged to sequence type detected more than once, and fourteen of these were multidrug resistant. Through solid plate mating, beta-lactam-resistantqnrS1-tet-dfrA14-positive strains bearing IncFI-, IncHI2, and IncHI2A successfully transferred ampicillin resistance to a nalidixic acid-resistant derivative ofE. coli-C600. This research highlights the urgent need to safeguard household water sources against fecal contamination to curb the dissemination of ARGs among bacterial populations in this environment.