bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation and Cancer Development: Basic Mechanisms and Evidence
of its Regulation by Hibiscus sabdariffa Natural Extracts
Authors: Espinosa-Sánchez Astrid , López-Santillán Iris Cristina , Duarte José Antonio Estefes , García-Cordero Antonio Luis , Muñóz-Pérez Victor Manuel , Castro-Rosas Javier 
Published: January 2025

Background:
Hibiscus sabdariffa is a plant used in traditional medicine for intestinal
treatments and nowadays for critical diseases like hypertension, diabetes, and cancer. Multidisciplinary
approaches have demonstrated, through Hibiscus sabdariffa extracts, anti-inflammation and
anti-cancer beneficial properties from compounds like phenols, flavonoids, and anthocyanins that are
ubiquitously distributed in whole plants.

Objective:
The objective of this study is to identify the bioactive compounds and their underlying
mechanisms of action that drive the anti-cancer and anti-inflammatory properties of Hibiscus sabdariffa
extracts

Methods:
We searched databases for publications in English from all years that reported beneficial
anti-inflammation and anti-cancer properties from Hibiscus sabdariffa extracts and their proposed
mechanism of action. We used Pubmed, Google Scholar, Scopus, and ScienceDirect for original
articles that included different Hibiscus sabdariffa extracts evaluated for their anti-inflammation, and
anti-cancer properties, using the following search terms: “H. sabdariffa”, “H. sabdariffa extracts”,
“H. sabdariffa and inflammation”, and “H. sabdariffa and cancer”. Some articles from the reference
list were used to collect additional information, and we used 73 articles in total.

Results:
In general, extracts from Hibiscus sabdariffa are obtained by different methods that affect
the final concentration of the compounds. Several in vivo and in vitro experiments show their antiinflammatory
and anti-cancer properties.

Conclusion:
Hibiscus sabdariffa extracts have the potential bioactivity to modulate inflammation
and cancer in several cellular and molecular mechanisms of action involving the downregulation of
key signaling pathways such as NFκB, MAPK, BCL-2, p53, among others, and the upregulation of
protective pathways such as Nrf2. However, research needs to be further evaluated on the exact
compounds that have this effect, in order to know if the extracts work individually or synergistically.
Synthesis and Catalytic Application of Cu2O Nano Hollow Arrays in RingExpansion Aromatization Reactions
Authors: Ebrahimzadeh Farzaneh 
Published: January 2025

Introduction:
Aromatization of dithioacetal derivatives is essential for the synthesis of
bioactive compounds and drug design, playing a key role in pharmaceuticals, agrochemicals, and
materials science. This study explores the synthesis and catalytic application of Cu2O nano hollow
arrays in ring-expansion aromatization reactions of cyclic dithioacetal derivatives obtained from
cyclohexanones.

Methods:
By using Cu2O nano hollow arrays prepared through molecular templates and a simple
hydrothermal process, the electrophilicity of N-bromosaccharin was enhanced, allowing for efficient and selective production of aromatic compounds with yields ranging from 63-96%. Copper
acetate is transformed into Cu2O nano hollow arrays in aqueous media, with polyvinylpyrrolidone
acting as a capping agent and (+)-L-tartaric acid as a structure-directing surfactant and multidentate
ligand.

Results:
The synthesized Cu2O nano hollow arrays were characterized using transmission electron
microscopy (TEM), field emission scanning electron microscopy (FESEM), energy-dispersive Xray spectroscopy (EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) to
verify their morphology, structure, and composition.

Conclusion:
This method not only offers a cost-effective and environmentally friendly approach to
synthesizing Cu2O with unique nano hollow structures, but also demonstrates their efficacy as catalysts in organic synthesis, particularly in the rarely reported ring-expansion aromatization of cyclic
dithioacetal derivatives of cyclohexanone, emphasizing their broader applicability in materials science and catalysis.
Ricinus Communis: Unlocking the Potential of a Medicinal Powerhouse
Authors: Goel Vrinda , Kumar Vijay , Bajaj Sakshi , Garg Kalpana , Kamboj Mohit , Chopra Bhawna 
Published: January 2025

Background:
The Euphorbiaceae family comprises over 7,500 species and 300 gen-era, with the castor bean plant, Ricinus communis, being one of the most valuable traditional and medicinal plants. Phytochemical assessments have shown that R. communis possesses a broad variety of chemical compounds with interesting pharmacological properties. This plant exhibits numerous beneficial properties, including effects against implantation failure, anti-fertility, antinociceptive, anticancer, antioxidant, hepatoprotective, immunomodulatory, anti-diabetic, antimicrobial, antiulcer, insecticidal, molluscicidal and larvicidal, bone regeneration, central analgesic, antihistaminic, antiasthmatic, cytotoxic, lipolytic, anti-inflammatory, and wound healing activities.

Objective:
The review aims to examine the pharmacological properties, phytochemical com-position, and potential applications of Ricinus communis as a plant source. Given its diverse range of phytochemicals and pharmacological activities, R. communis may be a promising option for the discovery of innovative complementary medicines.

Methods:
This review will involve an extensive analysis of existing literature on Ricinus com-munis. Sources will include peer-reviewed journals, clinical studies, and traditional medicine texts. The focus will be on identifying the pharmacological properties, therapeutic potential, and safety profile of the plant, along with its phytochemical composition.

Result:
The pharmacological, therapeutic, and safety potential of Ricinus communis and its phytochemicals as herbal and complementary medicine for treating various illnesses and dis-orders require further investigation through advanced clinical and experimental research.

Conclusion:
This review underscores the need for continued exploration of R. communis to unlock its full potential as a source of innovative medicinal therapies.
The Effects of Credit Risk, Liquidity Risk, And Capital on Profitability in State-Owned Bank Association with Credit Restructuring as The Moderator
Authors: Aghata Christy Cahya Widhi Andini  , Indraswari Citra Rahayu 
Published: January 2025

Credit restructuring is an important things for managing credit risk and improving bank financial stability. However, the effect on profitability varies depending on the context and how this process affects credit risk, liquidity risk, and capital adequacy. This research aims to determine how the new policy of Indonesian Financial Accounting Standard 71 (PSAK 71) which regulates Allowance for Impairment Losses (CKPN) helps in supporting optimal credit restructuring, so that the variables analyzed include NPL, LDR, and CAR which affect ROA with credit restructuring as a moderation. The data analysis technique used is Moderated Regression Analysis (MRA). The data used is secondary data from Himbara's financial reports covering data from 2016 to 2023 on a quarterly basis. The research results found that partially NPL and CAR had an effect on ROA while LDR had no effect on ROA. While credit restructuring weakens the influence of NPL and CAR on ROA, credit restructuring strengthens the influence of LDR on ROA. In this research, credit restructuring acts as a pure moderator.

Abstrak
Restrukturisasi kredit adalah alat penting untuk mengelola risiko kredit dan meningkatkan stabilitas keuangan bank. Namun, efeknya terhadap profitabilitas bervariasi tergantung pada konteks dan bagaimana proses ini mempengaruhi resiko kredit, resiko likuiditas, dan kecukupan modal. Penelitian ini bertujuan untuk mengetahui bagaimana kebijakan baru Standar Akuntansi Keuangan Indonesia 71 (PSAK 71) yang mengatur tentang Cadangan Kerugian Penurunan Nilai (CKPN) membantu dalam mendukung restrukturisasi kredit yang optimal, sehingga variabel yang dianalisis meliputi NPL, LDR, dan CAR yang mempengaruhi ROA dengan restrukturisasi kredit sebagai moderasi. Teknik analisis data yang digunakan adalah Moderated Regression Analysis (MRA). Data yang digunakan adalah data sekunder laporan keuangan Himbara mencakup data dari tahun 2016 hingga 2023 secara triwulan. Hasil penelitian menemukan bahwa secara parsial NPL dan CAR berpengaruh terhadap ROA sedangkan LDR tidak berpengaruh terhadap ROA. Serta restrukturisasi kredit memperlemah pengaruh NPL dan CAR terhadap ROA, namun restrukturisasi kredit memperkuat pengaruh LDR terhadap ROA. Dalam penelitian ini restrukturisasi kredit berperan sebagai moderator murni.
The state and development trends of the creative economy
Authors: Polishchuk O. A. , Gracheva N. A. , Dushkina V. A. , Kovaleva M. V. 
Published: January 2025

Relevance. In the modern world, due to the development of digital technologies and artificial intelligence, jobs are being cut. One of the ways to save jobs and create new ones is creative industries related to human creative activity, which cannot be automated.The relevance of creative industries is also expressed in expanding the tax base, by entering international and regional markets of high-quality products with higher added value; in reducing the imbalances of socio-economic development, increasing the comfort level of the urban environment, by using the potential of creative industries.The purpose of the article is to study the impact of the creative sector on the economy of the country and its regions.Objectives. To study the regulatory framework for regulating creative industries; to assess interest in creative industries; to consider the history of the formation of the creative economy; to study foreign experience; to analyze the state of development of creative industries in Russia and the regions of the Black Earth region; to consider the opinions of experts on the prospects for the development of the creative economy in the country and regions.Methodology. During the scientific research empirical, theoretical, statistical methods and methods of graphical representation were used.Results: the theoretical aspects of the development of the creative economy were studied, and the popularity of this sector in the modern world was shown. The state and development trends of creative industries in general in Russia and individual regions are analyzed. Foreign experience in the development of the creative economy has also been studied. Examples of the positive effect of the development of the creative sector are shown.Conclusions. The article highlights the relevance and importance of the topic under consideration, taking into account current trends and development prospects. The possibilities offered by the development of the creative economy, which is the engine of the rest of the economy, are considered. The successful development of creative industries requires a comprehensive government policy aimed at creating favorable conditions for creative activity, financing creative projects and training specialists.
Peculiarities of the development of the digital twins market
Authors: Kravchenko A. A. 
Published: January 2025

Relevance. The current state and prospects for further diffusion of digital twins into the business processes of industrial companies indicate a growing interest in the digital twin technology market. First of all, this is due to scientific and technological progress, increasing the maturity of technological solutions themselves, which opens up new business opportunities. Secondly, due to the expansion of the competencies of managers in the field of extracting commercial benefits, achieving social, environmental and technological effects, solutions in the form of twins contribute to the growth of the company's competitiveness in the context of digital transformation.The purpose of the study is to identify the features inherent in the digital twin’s market.Objectives: to study the digital twins’ market; to analyze the cases of the introduction of digital twins in the global and Russian markets; to identify trends in the digital twins’ marketMethodology. The research methodology includes the analysis of market dynamics data, analytical reports, methods of systematization, graphical representation of data.Results. The peculiarities in the development of the digital twins’ market were identified both at the global level and in Russia. When analyzing the financial indicators of the DT market, there is a positive increase year-on-year, which highlights not only the great potential of the technology, but also the growing demand for digital solutions based on twins. The analysis revealed a growing trend of companies to introduce “holistic digital twins”, which increases dependence on a single supplier.Conclusions. The global digital twin technology market is represented by industrial digital giants. The Russian market is currently very dependent on government orders, private business does not generate much demand. However, Russian CD's have great export potential. There is a trend in the market to move from installing separate data center elements from different providers to implementing a single platform data center from one supplier and integrating all corporate systems into it
Occupational Infections Among Workers in Europe: Protocol for a Scoping Review
Authors: Dini Guglielmo , Curti Stefania , Rahmani Alborz , Durando Paolo , Mattioli Stefano 
Published: January 2025

Background
Workers may be exposed to different infectious agents, putting them at risk of developing occupational diseases. This can occur in many ways, through deliberate use of speciﬁc microorganisms or through potential exposure from close contact with biological material. Infection prevention and control measures against biohazards can reduce the risk of infection among workers. During the last few decades, an increasing proportion of workers in Europe have been exposed to infectious biological agents in their workplace. Knowledge gaps on this topic in Europe have limited our understanding of the overall phenomenon in occupational settings.

Objective
This study aims to understand the extent and type of evidence on the epidemiology of occupational or work-related infections caused by bacterial, viral, fungal, and parasitical agents in European countries, the factors affecting their occurrence among workers, and the burden of disease among workers due to occupational risk.

Methods
The review will be conducted following the Joanna Briggs Institute methodology for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. This review will consider studies that include data on the epidemiology of occupational infections, risk factors and determinants, and burden of disease among workers employed in specific occupational sectors in European countries in the period 2010-2023. The search will include MEDLINE, Web of Science, and Scopus databases. Independent reviewers (including GD, SC, AR, PD, and SM) will screen the titles, abstracts, and full texts of the selected studies. Data extraction will be performed using a tool developed by the researchers. The data will be mapped and analyzed according to the type of extracted data.

Results
The literature search through different scientific databases started in April 2024 and is expected to be completed by December 2024. The findings will be extracted using an ad hoc data extraction tool, and relevant results will be presented in narrative and tabular form.

Conclusions
This scoping review aims to provide rigorous evidence to fill the knowledge gap in the epidemiology of occupational or work-related infections in European countries, the factors affecting their occurrence, and the burden of disease in different professional settings. Such findings could improve the understanding of this complex occupational phenomenon in the European context, enabling more accurate and up-to-date surveillance of infections incurred in the workplace.

International Registered Report Identifier (IRRID)
PRR1-10.2196/59606
COMPOSITION OF CONFORMAL AND PROJECTIVE MAPPINGS OF GENERALIZED RIEMANNIAN SPACES IN EISENHART’S SENSE PRESERVING CERTAIN TENSORS
Authors: Petrović Miloš Z. 
Published: January 2025

The composition of conformal and projective mappings between Riemannian spaces that were at the same time harmonic had been studied by S. E. Stepanov,I. G. Shandra in 2003 and further developed in I. Hinterleitner’s Ph.D. thesis in 2009. Conformal and projective mappings of Riemannian spaces preserving certain tensors were studied by O. Chepurna in the 2012 Ph.D. thesis. We consider conformal and projective mappings of generalized Riemannian spaces in Eisenhart’s sense and find necessary and sufficient conditions for these mappings to preserve curvature, Ricci and traceless Ricci tensors and some of their linear combinations. Particularly, as an additional contribution to related results collected in the Ph.D. thesis by O. Chepurna, we find that the following result holds in the case of Riemannian spaces: if a conformal mapping f1 : M → M^ is preserving the traceless Ricci tensor and a projective mapping f2 : M^ → M is preserving the traceless Ricci tensor then the Yano tensor of concircular curvature is invariant with respect to the composition f3 = f1 ◦ f2 : M → M.
THE FERMAT-TORRICELLI PROBLEM IN NORMED SPACES
Authors: Ilyukhin Daniil A. 
Published: January 2025

The article studies a generalization of the classical Fermat-Torricelli problem to normed spaces of arbitrary finite dimension. Given integer n, we describe all normed spaces such that the solution of the Fermat-Torricelli problem is unique for any n points in this space. More precise conditions for normed planes and three-dimensional spaces are presented. In addition, we apply the criterion to norms whose unit balls are regular polyhedra.
La ciencia detrás de lo cotidiano: una propuesta didáctica que aborda la contaminación por plásticos en el mar
Authors: Pérez-Vázquez Alan Javier , Méndez-Vargas Nadia Teresa 
Published: January 2025

¿Alguna vez te imaginaste realizar experimentos fuera del laboratorio escolar? Para el caso de las ciencias naturales, uno de los retos es el de no desligar la parte teórica de la experimental. El propósito de este trabajo es presentar una secuencia didáctica que aborda el tema de contaminación de cuerpos de agua por plásticos, a partir de realizar cuatro experimentos caseros. Uno es sobre la densidad de líquidos, el segundo sobre cómo se calcula la densidad de un sólido, el tercero sobre el principio de Arquímedes, y el cuarto sobre corrientes marinas por convección. Así, se contempla el uso de materiales caseros y metodologías de fácil acceso que den respuesta a una problemática ambiental como la contaminación de cuerpos de agua por plásticos. Esta propuesta didáctica se implementó en estudiantes de sexto semestre durante el primer semestre del año 2021. Como resultado, se tuvo que los alumnos pudieron construir argumentos y contraargumentos, formularon hipótesis o preguntas, entre otras habilidades científicas. Se pudo constatar el mejoramiento del aprendizaje de las ciencias con apoyo de la actividad experimental casera.
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Un experimento sencillo para ilustrar las inversiones del campo magnético terrestre
Authors: Ortiz-Olvera Violeta , Calmus Thierry 
Published: January 2025

Entender y divulgar los procesos geológicos representa una dificultad pedagógica por múltiples razones, entre ellas la necesidad de conocer conceptos de diversas ciencias básicas para explicar cada proceso. Es el caso de los fenómenos relacionados con la Tectónica de Placas, como la formación de nueva corteza oceánica y cómo ocurre el desplazamiento de los continentes conforme crece el piso oceánico. Este artículo presenta un experimento sencillo, accesible y de bajo costo que permite visualizar y entender el origen, la generación y la migración de las anomalías magnéticas que se forman en las dorsales oceánicas. El experimento se acompaña de una explicación de los conceptos básicos como el campo magnético terrestre, el proceso de magnetización, la magnetización termorremanente y la estructura de la dorsal oceánica. También se resaltan las implicaciones que se tuvieron para entender este proceso durante el desarrollo de la teoría de la Tectónica de Placas.
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Importancia relativa de los conceptos erróneos sobre el cambio climático
Authors: Bastien-Montoya Gustavo , Bastien-Olvera Bernardo , Pilatowsky-Gruner Raiza , Gay-Garcia Carlos 
Published: January 2025

Los conceptos erróneos son razonamientos equivocados muy arraigados que se resisten a cambiar incluso cuando se abordan mediante la enseñanza. En el campo del cambio climático y la educación ambiental, se han estudiado los conceptos erróneos con el fin de rectificar la comprensión errónea del tema, especialmente en los estudiantes, que serán los responsables de la toma de decisiones en un mundo futuro que experimentará los mayores impactos del cambio climático. Algunos de los conceptos erróneos más dominantes están relacionados con la incomprensión de la capa de ozono, el efecto invernadero y el concepto de calentamiento global. Sin embargo, se sabe muy poco sobre cómo se relacionan estos conceptos erróneos entre sí y si existen diferentes niveles de importancia entre ellos. Aquí demostramos que los conceptos erróneos particulares sobre el cambio climático y las interacciones específicas entre ellos funcionan como predictores de la incomprensión general del tema. Para ello, analizamos las respuestas de los estudiantes universitarios a las encuestas sobre los conceptos del cambio climático utilizando métodos de bosque aleatorio. A diferencia de estudios anteriores que han proporcionado una lista categórica de conceptos erróneos sobre el cambio climático, este estudio encuentra los niveles de importancia relativa entre los conceptos erróneos, revelando que la creencia de que el agujero en la capa de ozono es la causa principal del cambio climático y que el efecto invernadero ha sido provocado por los seres humanos. Estos son conceptos erróneos significativos que también actúan como predictores de la incomprensión general del tema. Estos resultados nos permiten identificar las ideas clave con las que los alumnos tienen más dificultades. Este estudio podría servir como punto de partida para comprender la interrelación de ideas que hacen del cambio climático un campo de estudio complejo.
PERAN MAJELIS PERMUSYAWARATAN ULAMA (MPU) BANDA ACEH DALAM MEWUJUDKAN KOTA GEMILANG DALAM BINGKAI SYARIAH
Authors: Usman Bustamam 
Published: January 2025

Majelis Permusyawaratan Ulama (MPU) Kota Banda Aceh merupakan lembaga yang memiliki tujuan untuk mewujudkan kota Banda Aceh menjadi model kota gemilang dalam bingkai Syariah. Oleh karena itu MPU harus memiliki peran yang aktif dan strategis demi terwujudnya masyarakat bersyariah di Kota Banda Aceh. Penelitian ini bertujuan untuk mengetahui peran MPU dalam mewujudkan Kota gemilang dalam bingkai Syariah dan untuk mengetahui tantangan yang dihadapi MPU dalam mewujudkan Kota gemilang dalam bingkai Syariah Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif analisis. Penelitian dilaksanakan di kantor MPU Kota Banda Aceh dengan subjek penelitian delapan informan menggunakan teknik purposive sampling. Adapun teknik pengumpulan data yaitu dengan wawancara dan studi dokumentasi. Kemudian pengolahan data dilakukan dengan tahap reduksi data, penyajian data, dan gambaran kesimpulan. Hasil penelitian menunjukkan bahwa peran MPU Banda Aceh dalam mewujudkan Kota Gemilang dalam bingkai Syariah, direalisasikan melaui kegiatan mudzakarah ulama, melalui rapat kerja ulama, pengakaderan ulama, pengajian muslimat, dan melakukan penelitian. Adapun tantangan ya ng di hadapi MPU dalam mewujudkan Kota gemilang dalam bingkai Syariah berupa masyarakat Kota Banda Aceh yang majemuk, terjadinya pengeksploitasian orang lain, dan masyarakat Kota Banda Aceh yang kurang memahami terhadap visi dan misi Pemerintah Kota Banda Aeh mewujudkan Kota gemilangdalambingkai Syariah.