bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic diversity and population differentiation in Earliella scabrosa, a pantropical species of Polyporales
Authors: Olou Boris Armel , Hègbè Apollon D. M. T. , Piepenbring Meike , Yorou Nourou Soulemane 
Published: December 2023

AbstractEarliella scabrosa is a pantropical species of Polyporales (Basidiomycota) and well-studied concerning its morphology and taxonomy. However, its pantropical intraspecific genetic diversity and population differentiation is unknown. We initiated this study to better understand the genetic variation within E. scabrosa and to test if cryptic species are present. Sequences of three DNA regions, the nuclear ribosomal internal transcribed spacer (ITS), the large subunit ribosomal DNA (LSU), and the translation elongation factor (EF1α) were analysed for 66 samples from 15 geographical locations. We found a high level of genetic diversity (haplotype diversity, Hd = 0.88) and low nucleotide diversity (π = 0.006) across the known geographical range of E. scabrosa based on ITS sequences. The analysis of molecular variance (AMOVA) indicates that the genetic variability is mainly found among geographical populations. The results of Mantel tests confirmed that the genetic distance among populations of E. scabrosa is positively correlated with the geographical distance, which indicates that geographical isolation is an important factor for the observed genetic differentiation. Based on phylogenetic analyses of combined dataset ITS-LSU-EF1α, the low intraspecific divergences (0–0.3%), and the Automated Barcode Gap Discovery (ABGD) analysis, E. scabrosa can be considered as a single species with five different geographical populations. Each population might be in the process of allopatric divergence and in the long-term they may evolve and become distinct species.
Psychometric evaluation and cross-cultural adaptation of the Australian Pelvic Floor Questionnaire (APFQ-IR) in Iranian reproductive age women
Authors: Mashayekh-Amiri Sepideh , Asghari Jafarabadi Mohammad , Rashidi Fatemeh , Mirghafourvand Mojgan 
Published: December 2023

AbstractPelvic floor disorders (PFDs), as a silent alert, is one of the pervasive debilitating health concerns among women all over the world, such that in developed countries, one in four women, suffers from PFDs. Validity and reliability of the Australian Pelvic Floor Questionnaire (APFQ) has not been determined in Iran, so to determine APFQ’s psychometric characteristics, we decided to conduct this study on women of reproductive age in Tabriz city, Iran. This methodological cross-sectional study was intended to determine the psychometric properties of the Persian version of the APFQ-IR in 5 steps including “translation process, content validity, face validity, construct validity (exploratory and confirmatory factor analyses and examination of ceiling and floor effects) and reliability” on 400 reproductive age women referring to health centers in Tabriz city, Iran, with cluster random sampling method in the period between May 2022 to September 2022. The translation process was done based on two approaches, Dual panel, and Beaton et al.’s five steps. Then, in order to evaluate content validity, face validity, and construct validity, 10 instrument and PFDs experts, 10 women from the target group investigated the instrument's items, and 400 eligible women completed the instrument. Finally, to determine the reliability, two internal consistency methods, (Cronbach's alpha and McDonald's omega) and test–retest method (ICC) were used. In the present study, content validity assessment of APFQ-IR, showed a good level of validity (CVR = 0.96, CVI = 0.94). To assess construct validity, exploratory factor analysis results on 36 items, led to the identification of 4 factors including bladder function, bowel function, prolapse symptom and sexual function, which explained 45.53% of the cumulative variance and indicated the sufficiency of the sample size (Kaiser–Meyer–Olkin = 0.750). Implementing confirmatory factor analysis, (RMSEA = 0.08, SRMR = 0.08, TLI = 0.90, CFI = 0.93, χ2/df = 3.52) confirmed the model fit indices. Finally the internal consistency and reliability was high for the entire instrument (Cronbach’s alpha = 0.85; McDonald's omega (95% CI) = 0.85 (0.83–0.87) and Intraclass Correlation Coefficient (95% CI) = 0.88 (0.74–0.94)). The Persian version of the APFQ-IR, has a good validity and reliability and has acceptable psychometric properties, thus can be used both for research purposes and for clinical evaluation of pelvic floor disorders symptoms in health centers.
Effect of renin angiotensin system inhibitors on long-term major cardiovascular outcomes in patients with high atherosclerotic cardiovascular risk
Authors: Wongcharoen Wanwarang , Osataphan Nichanan , Gunaparn Siriluck , Srimahachota Suphot , Porapakkham Pornwalee , Dutsadeevettakul Somchai , Phrommintikul Arintaya 
Published: December 2023

AbstractThe advantage of angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) in patients with preserved LV systolic function is uncertain. We aimed to investigate the effects of ACEI/ARB in high atherosclerotic risk patients without overt heart failure (HF) on long-term major cardiovascular outcomes (MACEs). The Cohort Of patients with high Risk for cardiovascular Events (CORE-Thailand) registry is a prospective, multicenter, observational, longitudinal study of Thai patients with high atherosclerotic risk. The patients with ejection fraction < 50% were excluded. Among 8513 recruited patients, there were 4246 patients included into final analysis after propensity score matching. At 5-years follow-up, Cox regression analysis showed that ACEI/ARB was significantly associated with reduced risk of all-cause mortality or non-fatal myocardial infarction, non-fatal stroke and HF hospitalization (HR 0.82, 95% CI 0.70–0.96, P = 0.011). The benefit was driven by the reduced all-cause mortality and HF. Subgroup analysis demonstrated that ACEI/ARB decreased risk of long-term MACEs in patients with diabetes (HR 0.77, 95% CI 0.63–0.94, P = 0.011) and patients not taking statin (HR 0.57, 95% CI 0.40–0.82, P = 0.002). We demonstrated that the use of ACEI/ARB was associated with reduced risk of long-term MACEs in a large cohort of high atherosclerotic risk patients. Reduction of all-cause mortality and HF were likely the main contributors to the benefit of ACEI/ARB.
Pseudorabies virus causes splenic injury via inducing oxidative stress and apoptosis related factors in mice
Authors: Sun Wei , Liu Shanshan , Yan Yi , Wang Qingyan , Fan Yu , Okyere Samuel Kumi 
Published: December 2023

AbstractPseudorabies virus (PRV) is an immunosuppressive virus that causes significant damage to the pig industry. This study aimed to investigate the effects of PRV on oxidative stress and apoptotic related in the spleen of mice to provide basis knowledge for further research on the pathogenesis of PRV in mice model. 36 mice were randomly two groups, the control group which only received 200 μL PBS and infection group which was subcutaneously infected with 200 μL of 1 × 103 TCID50/100 μL PRV, respectively. Spleen tissues in each group were collected for further experiments at 48, 72, and 96 h post-infection (hpi). Pathological observation was performed by hematoxylin and eosin Y staining. Biochemical and Flow cytometry methods were used to determine the reactive oxygen species profile and apoptosis of the spleen post-infection and apoptosis detection. In addition, q-PCR and Western blot were adopted to measure the apoptotic conditions of the spleen infected with PRV. The results indicated that the reactive oxygen species (ROS) level in the PRV infection group was remarkedly increased (p < 0.01) at a time-dependent pattern. Furthermore, the Malondialdehyde levels in the spleen of mice in the infection group increased (p < 0.01) in a time-dependent mode. However, the activity of Catalase, Superoxide dismutase, and glutathione peroxidase and the content of Glutathione in the infection group were decreased with the control group (p < 0.01) at a time-dependent manner. In addition, the ratio of splenocyte apoptosis in the infection group significantly increased (p < 0.01) in a time-dependent manner. In conclusion, PRV infection causes apoptosis of the spleen via oxidative stress in mice.
Microbial processes with the potential to mobilize As from a circumneutral-pH mixture of flotation and roaster tailings
Authors: Pakostova Eva , Hilger David M. , Blowes David W. , Ptacek Carol J. 
Published: December 2023

AbstractThe Northwest Tailings Containment Area at the inactive Giant Mine (Canada) contains a complex mixture of arsenic-containing substances, including flotation tailings (84.8 wt%; with 0.4 wt% residual S), roaster calcine wastes (14.4 wt% Fe oxides), and arsenic trioxide (0.8 wt%) derived from an electrostatic precipitator as well as As-containing water (21.3 ± 4.1 mg L−1 As) derived from the underground mine workings. In the vadose zone the tailings pore water has a pH of 7.6 and contains elevated metal(loid)s (2.37 ± 5.90 mg L−1 As); mineral oxidizers account for 2.5% of total 16S rRNA reads in solid samples. In the underlying saturated tailings, dissolved Fe and As concentrations increase with depth (up to 72 and 20 mg L−1, respectively), and the mean relative abundance of Fe(III)-reducers is 0.54% of total reads. The potential for As mobilization via both reductive and oxidative (bio)processes should be considered in Giant Mine remediation activities. The current remediation plan includes installation of an engineered cover that incorporates a geosynthetic barrier layer.
Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs
Authors: Martínez-Domínguez Samuel J. , García-Mateo Sandra , Sainz-Arnal Pilar , Martínez-García Javier , Gallego-Llera Beatriz , Lozano-Limones María Jesús , Hidalgo Sandra , Gargallo-Puyuelo Carla J. , Latre-Santos Marta , Nocito-Colon Maria Mercedes Lourdes , Martínez-Lostao Luis , Refaie Engy , Arroyo-Villarino Maria Teresa , del Rio-Nechaevsky Marcela , Ramirez-Labrada Ariel , Pardo Julián , Gomollón Fernando , Baptista Pedro M. 
Published: December 2023

AbstractSuboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy.
Delaunay meshes simplification with multi‐objective optimisation and fine tuning
Authors: Fan Linkun , Wu Caiyun , He Fazhi , Fan Bo , Liang Yaqian 
Published: December 2023

Abstract3D meshes simplification plays an important role in many industrial domains. The two goals of Delaunay mesh simplification are maintaining high geometric fidelity and reducing mesh complexity. However, they are conflicting and cannot solved by gradient. Such limitation prevents existing Delaunay mesh simplification to obtain a small enough number of vertices and promising fidelity at the same time. To address these issues, this paper proposes an evolutionary multi‐objective approach for Delaunay mesh simplification. Firstly, the authors replace the previous fixed error‐bound threshold by the designed adaptive segment‐specific thresholds. Secondly, a constrained simplification is performed through a series of edge collapses that satisfy both Delaunay and error constraints. Next, the non‐dominated sorting genetic algorithm II (NSGA‐II) is employed to solve the multi‐objective problem to search for the optimal trade‐off threshold sequences. Finally, a fine‐tuning method is designed to further enhance the geometric fidelity of the simplified mesh. Experimental results demonstrate that the authors’ method consistently achieves a satisfactory balance between the approximation error and number of vertices, outperforming existing state‐of‐the‐art methods.
Assessing the moisture content of oil‐impregnated paper bushings with a simple and fast method
Authors: Ansari Hossein Taghizade , Vahedi Abolfazl 
Published: December 2023

AbstractPower outages can cause harm to both society and individual health. Among the crucial elements of power systems, power transformers play a vital role, and their failures can lead to incidents and disruptions. According to statistics, almost 50% of the explosions and fires in the power transformer are caused by oil‐impregnated paper (OIP) bushing failures. Moreover, moisture is a crucial factor that affects the health of OIP bushings, and assessing the moisture level in OIP bushings is vital to guarantee the safety of power systems. While the frequency‐domain dielectric spectroscopy (FDS) method has been widely used to assess the moisture content of OIP bushings on‐site, it has the disadvantage of requiring a long measurement time. Therefore, a novel technique was proposed in this study that involves measuring the OIP bushing dissipation factor (tanδ) at 1 Hz to estimate the moisture content in a significantly shorter time. Five samples of OIP with various moisture levels have been selected, and an equation based on the OIPs' value of tanδ at 1 Hz was proposed to assess the moisture level of OIP bushings. Furthermore, the validity of the proposed method was successfully verified, proving its precision and time efficiency.
Novel reaching law based predictive sliding mode control for lateral motion control of in‐wheel motor drive electric vehicle with delay estimation
Authors: Chiliveri Vinod Rajeshwar , Kalpana R. , Subramaniam Umashankar , Muhibbullah Md , Padmavathi L. 
Published: December 2023

AbstractThe lateral motion control of an in‐wheel motor drive electric vehicle (IWMD‐EV) necessitates an accurate measurement of the vehicle states. However, these measured states are always affected by delays due to sensor measurements, communication latencies, and computation time, which results in the degradation of the controller performance. Motivated by this issue, a novel reaching law based predictive sliding mode control (NRL‐PSMC) is proposed to maintain the lateral motion control of the IWMD‐EV subjected to unknown time delay. Initially, a PSMC framework is built, in which a predictor integrating with the sliding mode control is designed to eliminate the effect of time delay and generate the virtual control signals. Further, to alleviate the chattering phenomenon, a novel‐reaching law is developed, enabling the vehicle to track the desired states effectively. Subsequently, a dynamic control allocation technique is presented to optimally allocate the virtual control input to the actual control input. The accurate estimation of the aforementioned unknown delay is realized through a delay estimator. Finally, simulation and hardware‐in‐the‐loop experiments are performed for three specific driving manoeuvres, and the results demonstrate the effectiveness of the proposed controller design.
Gravitoelectric effect in the condensed magnetic sea
Authors: Lee Jong hoon 
Published: December 2023

AbstractTrapped graviton in magnetic seas induces magnetic fields as a function of time in the additional space. The Soon Joe generator made the Graviton set behave as free relativistic quantum particles. The current and voltage generated when the LED was turned on and off were measured five times. Measurements were made in units of 1/1000 of a second, and the measured data were summed. In the LED off‐state, the average current was −2.87E‐03 (A), and the average voltage was −1.44E‐01 (V) in VH and 6.83E‐01 (V) in VL. The average current in the LED on‐stage was −4.28E‐03, the VH was 2.14E‐01, and the VL was 6.57E‐01. The voltage difference was −8.27E‐01 in the off‐stage and −8.71E‐01 in the on‐stage. Less current was generated in the off‐stage, with less voltage difference. In this experiment, we confirmed that the graviton generates the current, and with the photons, more current is generated. This explains why the interactive induction protocol of gravitons or photons can be used to experiment with the magnetic field's ability to communicate or transfer energy with relativistic quantum particles. The gravitoelectric effect explains the photoelectric effect elements, and graviton has induced electricity as a physical entity in the magnetic sea.
Investigation on damping mechanism of machine‐side dynamics of permanent magnet synchronous generator‐based wind generation system
Authors: Zhou Xianyu , Bu Siqi , Zhou Bowen , Yang Dongsheng , Meegahapola Lasantha 
Published: December 2023

AbstractA permanent magnet synchronous generator‐based wind generation system has been predominantly applied in wind farms. With the wide application of wind generation, mechanical shafting attracts wide attention as torsional vibration problems may occur in its mechanical rotational system, which can further affect the power system. The paper first intentionally designs a two‐open‐loop two‐mass shaft subsystem model to investigate the interactions among wind turbine mass, generator mass, and machine‐side converter, that is, the machine‐side dynamics. Then, a bilateral damping contribution analysis is proposed to investigate the damping mechanism of these machine‐side dynamics. The impact mechanism of one dynamic on another through the damping contribution channel can be revealed by modal analysis, indicating the coupling of different oscillation modes and the complex interactions of machine‐side dynamics. The established two‐open‐loop two‐mass shaft subsystem model and the proposed bilateral damping contribution analysis with the identified damping contribution channel of the permanent magnet synchronous generator‐based wind generation system are validated.
Interaction between Neurogenic Pulmonary Edema and Thoracic 3 DRG Degeneration Following Spinal Subarachnoid Hemorrhage: First Experimental Study
Authors: Sirinoglu Deniz , Sarigul Buse , Kanat Ayhan , Aydin Mehmet Dumlu , Demirtas Rabia 
Published: December 2023

Abstract
Background Neurogenic pulmonary edema (NPE) following subarachnoid hemorrhage (SAH) is still one of the most catastrophic complications with high morbidity and mortality rates. Systemic sympathetic hyperactivity has been considered in the pathogenesis, but it has not been clarified. In this study, we investigate the relationship between the degeneration of the T3 dorsal root ganglion (DRG) and the development of NPE following spinal SAH.
Methods The study was conducted on 23 rabbits. Five rabbits were used as the control group, 5 as the sham group (n = 5), and 13 as the study group. The correlation between the degenerated neuronal densities of the T3 nerve axons and neurons in the DRG and NPE scores was analyzed statistically.
Results A correlation between the neuronal degeneration of the T3 nerve, its DRG, and high NPE scores was found in the study group and the sham group. Massive NPE was detected in the study group along with neural degeneration of T3 axons and ganglia.
Conclusion The present study indicates that NPE and pulmonary artery vasospasm can be prevented by reducing T3 DRG degeneration.
Utility of Simple and Non-Invasive Strategies Alternative to Inferior
Petrosal Sinus Sampling and Peripheral CRH Stimulation in Differential Diagnosis
of ACTH-Dependent Cushing Syndrome
Authors: Attri Bhawna , Goyal Alpesh , Kalaivani Mani , Kandasamy Devasenathipathy , Gupta Yashdeep , Agarwal Shipra , Shamim Shamim A. , Damle Nishikant , Sharma Mehar Chand , Jyotsna Viveka P. , Suri Ashish , Tandon Nikhil 
Published: December 2023

AbstractWe aimed to evaluate the utility of simple, cost-effective, and non-invasive
strategies alternative to BIPSS and peripheral CRH stimulation in differential
diagnosis of ACTH-dependent CS. First, we performed ROC analysis to evaluate the
performance of various tests for differential diagnosis of ACTH-dependent CS in
our cohort (CD, n=76 and EAS, n=23) and derived their optimal
cut-offs. Subsequently, combining various demographic (gender), clinical
(hypokalemia), biochemical (plasma ACTH, HDDST, peripheral CRH stimulation) and
imaging (MRI pituitary) parameters, we derived non-invasive models with
100% PPV for CD. Patients with pituitary macroadenoma (n=14)
were excluded from the analysis involving non-invasive models. Relative percent
ACTH (AUC: 0.933) and cortisol (AUC: 0.975) increase on peripheral CRH
stimulation demonstrated excellent accuracy in discriminating CD from EAS. Best
cut-offs for CD were plasma ACTH<97.3 pg/ml,
HDDST≥57% cortisol suppression, CRH
stimulation≥77% ACTH increase and≥11% cortisol
increase. We derived six models that provided 100% PPV for CD and
precluded the need for BIPPS in 35/85 (41.2%) patients with
ACTH-dependent CS and no macroadenoma (in whom BIPSS would have otherwise been
recommended). The first three models included basic parameters and avoided both
peripheral CRH stimulation and BIPSS in 19 (22.4%) patients, while the
next three models included peripheral CRH stimulation and avoided BIPSS in
another 16 (18.8%) patients. Using simple and non-invasive alternative
strategies, BIPSS can be avoided in 41% and peripheral CRH stimulation
in 22% of patients with ACTH-dependent CS and no macroadenoma; such
patients can be directly referred for a pituitary surgery.