bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing the global water crisis: a comprehensive review of nanobiohybrid applications for water purification
Authors: Kalyan I. , Nayak A. K. , Khobragade M. U. 
Published: January 2024

Abstract
Systematic and organized handling of pre-existing and ever-emerging pollutants, which are continuously contaminating the freshwater resources and causing severe problems in aquatic bodies, aerial environments, and earthbound flora and fauna, is an absolute must. These pollutants contribute to one of the major global problems of scarcity of pristine water for daily use. In the last decades, different types of water cleaning and purification techniques have been embraced to address the issue. Traditional and standard water purification techniques have several shortcomings, like high time consumption, expensive operation and maintenance, and lower affinity with low efficiency toward newly emerging micropollutants. The circumstances demand that we adopt and develop a relatively new purification approach through ‘nanobiohybrids.’ Though for a long time, nanomaterials, nanohybrids, and enzymes have previously been used for water treatment, each of these materials has its unique challenges. Advance oxidation processes, production of toxic intermediates, lesser selectiveness and sensitivity toward dilute solutions, catalyst leaching and for enzymes shorter shelf life, extreme sensitiveness toward mechanical stress, and separation difficulties for reuse are some major problems. Now, the combination of nanomaterials with biomolecules (especially enzymes), known as ‘nanobiohybrids,’ is a powerful combination that holds the potential to overcome the abovementioned issues due to their synergistic properties. In the synthesis of nanobiohybrids, carbon nanotubes or graphene oxide, offer an excellent support matrix for enzymes, and play a significant role. This chapter discusses the background of nanobiohybrids, their recent development as a favorite candidate for novel water purification techniques, and their future.
Assessing the feasibility of inorganic nanomaterials for nanohybrids formation
Authors: Pande Ranjana , Patil Anirudh Gururaj 
Published: January 2024

Abstract
Pollutant removal from industrial effluents is a big challenge for industries and these pollutants can have a great risk to the environment. Traditional methodologies for nanomaterials fabrication have drawbacks such as high energy consumption and use of toxic agents. But there is an option of green nanobiotechnology that synthesizes biogenic metal nanoparticles (Bio-Me NPs) with microbes. Biogenic metal NPs are produced at ambient biosynthesis conditions, and exhibit unique surface properties and crystalline structures, which can eliminate various contaminants from water. Microbes-based nanomaterials exhibit high-quality catalytic performance because of their greater number of active sites and higher surface area as compared to polycrystalline materials. Hence, microorganisms used for nanomaterial production can provide a novel approach for wastewater treatment and decontamination. This chapter focuses on the feasibility of nanomaterials for microbes to fabricate nanohybrids for wastewater treatment and decontamination. Apart from this, the use of microbial fuel cells to not only treat wastewater but also generate electricity in the process is discussed.
Feasibility of nanomaterials to support electroactive microbes in nanobiohybrids
Authors: Chen Zheng , Zeng Yanqiong , Wang Feng , Huang Peng , Li Jian , Chen Yibin 
Published: January 2024

Abstract
Electrochemically active bacteria (EAB) harboring extracellular electron transfer capabilities display great potential for applications in wastewater treatment and energy recovery. However, limited biocatalytic efficiency can curtail their practical engineering applications. Building on the merits of nanomaterials (NMs) that are biocompatible with EAB, engineered nanobiohybrids that are synergistically integrated with specific bacterial components and NMs provide a novel design for engineering an advanced biocatalyst complex. In this chapter, we summarize the efficacy of NMs for their suitability in constructing nanobiohybrids. Favorable engineered nanobiohybrids attributes include high electrical conductivity, large specific surface area, desirable photocatalytic capability, stimulated production of cellular components related to electron transfer, and cytoprotection capabilities. Considering the mechanisms of interfacial electron transport and electron flux generation, the configuration of nanobiohybrids with NMs can be implemented through both endogenous and exogenous bioaugmentation, wherein nanobiohybrids are constructed at a single cell-based or biofilm-based scale with different interfacial connections. Finally, we summarize the current challenges for nanobiohybrid construction and envision the future prospects for nanobiohybrid development and applications.
Unlocking the potential of nanobiohybrids to combat environmental pollution
Authors: Gholap Amol D. , Hatvate Navnath T. , Sawant Sampada D. , Khemka Palak N. , Vora Lalitkumar K. 
Published: January 2024

Abstract
The destructive effects of the world's population growth, which have led to the overuse of primary resources, are evident today. Recently, the world has hit an 8 billion population mark, which is accompanied by an increase in waste generation. Anthropogenic activities lead to environmental pollution that is a problem of great importance, and it is essential to develop economically sound, eco-friendly, and sustainable technologies to tackle this ever-increasing problem of the 21st century. Innovations are required since they can contribute to the creation of sophisticated, sustainable, and novel goods for ecological repair. Such properties can be seen in the current advancements of nanotechnologies and new performing nanomaterials. They have a substantial surface area, enzymatic activity, and responsiveness and are easily functionalized to chemically modify their characteristics. This chapter examines current advancements in bioremediation methods used in conjunction with various nanocomposites and nanobiohybrids to recover the environment from pollution. Special focus is placed on environmentally friendly and regenerative nanosolutions, as well as their secure properties.
Role of Amphotericin B in the Treatment of Mucormycosis
Authors: Sachdeva Alisha , Targhotra Monika , Kanwar Chauhan Meenakshi , Chopra Monica 
Published: January 2024

Background:
Regardless of the most recent inclusion of mold-active agents (isavuconazole and
posaconazole) to antifungal agents against mucormycosis, in conjunction with amphotericin B (AMB) items,
numerous uncertainties still exist regarding the treatment of this rare infection. The order Mucorales contains a
variety of fungi that cause the serious but uncommon fungal illness known as mucormycosis. The moulds are
prevalent in nature and typically do not pose significant risks to people. Immunocompromised people are affected
by it.

Objective:
This article's primary goal is to highlight the integral role that AMB plays in this condition.

Methods:
Like sinusitis (including pansinusitis, rhino-orbital, or rhino-cerebral sinusitis) is one of the many
signs and symptoms of mucormycosis. The National Center for Biotechnology Information (NCBI) produces a
variety of online information resources for review articles on the topic-based mucormycosis, AMB, diagnosis
of mucormycosis and the PubMed® database of citations and abstracts published in life science journals. These
resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov.

Results:
The article provides a summary of the pharmacological attributes of the various AMB compositions
accessible for systemic use.

Conclusion:
The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability,
and other features, and illustrates their most useful characteristics for clinical application.
Recent Advances in the Synthesis and Applications of Phenylquinoline-4-carboxylic
Acid Derivatives: A Comprehensive Review
Authors: Saha Sunam , Pathak Devender , Shah Kamal 
Published: January 2024

Abstract:
Phenylquinoline-4-carboxylic acid derivatives have garnered significant attention
in recent years due to their diverse pharmacological and industrial applications. This comprehensive
review summarizes the latest advancements in the synthesis and diverse range of
applications of phenylquinoline-4-carboxylic acid derivatives. This review provides a brief
overview of the significance of phenylquinoline-4-carboxylic acid derivatives in medicinal
chemistry. It also explores the structural diversity achievable through modifications at various
positions of the phenylquinoline-4-carboxylic acid scaffold. The pharmacological applications
of phenylquinoline-4-carboxylic acid derivatives, such as anticancer, antimicrobial,
anti-inflammatory, and antiviral activities, are highlighted, underscoring their potential
as promising drug candidates. This comprehensive review provides a thorough overview of
the recent advances in the synthesis and applications of phenylquinoline-4-carboxylic acid derivatives. The
integration of synthetic methodologies, structural modifications and diverse applications makes this review a
valuable resource for researchers, scientists and professionals working in the fields of medicinal chemistry.
CT109-SN-38, a Novel Antibody-drug Conjugate with Dual Specificity for
CEACAM5 and 6, Elicits Potent Killing of Pancreatic Cancer Cells
Authors: Arias Cardenas Kelly C. , Enos Clinton W. , Spear Mark R. , Austin Dana E. , Almofeez Raghad , Kortchak Stephanie , Pincus Lauren , Guo Hua-bei , Dolezal Samuel , Pierce J. Michael , Furth Emma , Gineste Cyrille , Kwon Yongjun , Gelber Cohava 
Published: January 2024

Background:
CEACAM5 and CEACAM6 are glycosylphosphatidylinositol (GPI)-
linked members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family,
which are frequently upregulated in epithelial cancers where they contribute to invasion, metastasis,
immune evasion, and resistance to anoikis. CT109 is a novel antibody with dual specificity to
both CEACAM5 and 6.

Objective:
In this study, we aimed to perform the preclinical characterization of CT109 and antibody-
drug conjugate (ADCs) derivatives of CT109, focusing on CT109-SN-38.

Methods:
CT109’s cognate epitope was characterized by scanning mutagenesis. CT109 specificity
and internalization kinetics were assessed by immunoblot and flow cytometry, respectively. Cognate
antigen expression prevalence in colorectal cancer and normal tissue arrays was determined by
immunohistochemistry. CT109 conjugations were generated by the reaction of reduced CT109 cysteines
with maleimide-functionalized payload linkers. In vitro cytotoxic activity of CT109 ADCs
was characterized on antigen-positive and negative pancreatic ductal adenocarcinoma cell (PDAC)
lines using a luminometric viability assay. In vivo efficacy of CT109-SN-38 was assessed on a
PDAC tumor xenograft model at 10 and 25 mg/kg concentrations.

Results:
CT109 was shown to bind a glycoepitope centered on N309. CT109 is internalized in the
CEACAM5+/CEACAM6+ double-positive PDAC line, BxPC-3, with a t1/2 of 2.3 hours. CT109
ADCs elicit a dose and antigen-dependent cytotoxic effect, with CT109-SN-38 exhibiting an IC50
value of 21 nM in BxPC-3 cells. In a BxPC-3 tumor xenograft model, CT109-SN-38 reduced tumor
growth and induced regression in 3/10 mice at a concentration 25 mg/kg.

Conclusions:
These data suggest that further preclinical and clinical development of CT109-SN-38
is warranted.
Establishment and Validation of a Blood Test-based Nomogram
to
Diagnose Patients with AFP-negative HCC
Authors: Wu Yujing , Liu Shuang , Fan Zhijuan , Tian Yaqiong , Zhang Lei , Liu Shuye 
Published: January 2024

Background:
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer
death worldwide. Alpha-protein (AFP) is the most widely used blood biomarker for HCC. However,
elevated serum AFP is only observed in part of HCC.

Aims:
This study aimed to develop an efficient nomogram model to distinguish patients with alpha-
protein-negative HCC and liver cirrhosis.

Objective:
A total of 1130 patients (508 HCC patients + 622 cirrhosis patients) were enrolled in
the training cohort. A total of 244 HCC patients and 246 cirrhosis patients were enrolled in the
validation cohort.

Methods:
A total of 41 parameters about blood tests were analyzed with logistic regression. The
nomogram was based on independent factors and validated both internally and externally.

Results:
Independent factors were eosinophils %, hemoglobin concentration distribution width,
fibrinogen, platelet counts, total bile acid, and mitochondria aspartate aminotransferase. The calibration
curve for the probability of HCC showed good agreement between prediction by nomogram
and actual observation. The concordance index was 0.851. In the validation cohort, the nomogram
distinguished HCC from liver cirrhosis with an area under the curve of receiver operating
characteristic of 0.754. Conclusion: This proposed nomogram was an accurate and useful method
to distinguish patients with AFP-negative HCC from liver cirrhosis.

Conclusion:
This proposed nomogram was an accurate and useful method to distinguish patients
with AFP-negative HCC from liver cirrhosis.
Factors Affecting Early Retirement Intentions With the Mediating Mechanism of Job Engagement
Authors: Khan Asfand Yar , Bilal Dr. Atif , Daud Nadia , Daniyal Muhammad , Ahmed Bilal , Ishaq Atiq 
Published: January 2024

The main objective of this study is to empirically examine the associations between work goals (intrinsic and extrinsic) and early retirement intentions, with the mediating mechanism of work passion and the moderating role of flexible HR practices, spouse’s health, and position level (employees’ position level in organizations, e.g., junior manager at lower level, deputy manager at middle level, or senior manager at upper level etc.). Data for the study was collected through survey-based questionnaires distributed to a sample of 350 female employees from different public and private sector organizations in Pakistan. Testing of the hypotheses was conducted using structural equation modeling (SEM) with WarpPLS software. The findings indicate that employees’ work goals are positively related to the level of passion they feel about their work. However, this has a negative impact on their early retirement intentions. Besides, the results show that this work passion mediates the relationship between work goals and early retirement intentions. Furthermore, flexible HR practices, position level, and spouse’s health moderate the relationship between work passion and early retirement intentions. The study’s theoretical and managerial contributions and limitations are also discussed at the end of the article.
Succinate, silicon dioxide, aluminium oxide, and silver nano- and microparticle influence on the model organism Drosophila melanogaster
Authors:   University of Latvia, Institute of Biology, Ažēna Elīna , Krasņevska Nikole , Grauda Dace , Butkauskas Dalius ,   Nature Research Centre
Published: January 2024

n the study we subjected for biological testing succinate (5–3000 nm), silica (200–300 nm), aluminium (2500 nm), and silver (500–1000 nm) particles potentially applicable in the production of novel 3D biotextile. The effects of selected particles were evaluated in drosophila model by measuring the parameters potentially to be affected during the development. At the concentrations tested (0.01% and 0.1%), no clear adverse effects on egg to imago viability and locomotor activity, size, and phenotype of enclosed flies were found.
Macrophyte Fucus vesiculosus as habitat forming species in the Gulf of Riga, Baltic Sea
Authors:   University of Latvia, Institute of Biology, Boikova Elmīra , Kuļikova Irina 
Published: January 2024

In the Gulf of Riga the long-term studies of macrophyte communities and related environmental parameters started at 1999 till 2021. This is first research monitoring combining both species identification, productivity, by SCUBA diving and ecological mapping of two different subregions in the Gulf of Riga. The Fucus vesiculosus as habitat forming key species in relation to environment factors described.
Preliminary studies on natural enemies of hard ticks and methods of their population control in Latvia
Authors:   University of Latvia, Institute of Biology, Šilaks Artūrs , Salmane Ineta , Grodskis Eduards , Jankevica Līga ,   “Kukaiņu garāža” LTD
Published: January 2024

Hard ticks Ixodidae (Acari) transmit pathogens causing dangerous diseases such as tick-borne encephalitis and Lyme disease. These tick species in Latvia are dog tick Ixodes ricinus and taiga tick Ixodes persulcatus. The use of acaricides to control tick populations raises concerns over environmental pollution. Environmentally friendly way to control ticks is necessary to develop. Parasitoid tick wasp Ixodiphagus hookeri (Hymenoptera, Encyrtidae) are natural enemies of Ixodidae ticks. The aim of the current research was to study natural enemies of Ixodes spp. and determine causes of tick mortality, and development of methods for tick rearing in laboratory conditions. In order to carry out the artificial feeding of ticks, a prototype of a tick feeding device using skin-imitating membrane was created.
Typical berries of the hemiboreal zone: traditional use and the potential for cultivation – a short review
Authors:   University of Latvia, Institute of Biology, Laboratory of Plant Mineral Nutrition, Āboliņa Laura , Osvalde Anita ,   Latvia University of Life Sciences and Technologies
Published: January 2024

Wild berries – bilberry, lingonberry, cranberry, and cloudberry are typical boreal forest species and have been a source of food and traditional medicine since ancient times. Based on the SCOPUS database, this review evaluates the popularity of wild berries in Latvia and the world, comparing the latest scientific research on each species. The literature highlights the global popularity of bilberry and a notable research interest on cloudberry in Latvia. The large proportion of articles in health-related fields emphasizes the importance of using wild berries for health benefits.
The Upper Daugava meanders on the way to the World Heritage nomination
Authors:   University of Latvia, Institute of Biology, Boikova Elmīra 
Published: January 2024

In 2011 the UNESCO World Heritage Committee approved the Upper Daugava landscape area with nine impressive river meanders on the UNESCO Tentative List. This means that this area belongs to the UNESCO National Heritage. Although the protected landscape area “Augšdaugava” was established in 1991 and belongs to the NATURA 2000 network from 2004, the nature protection plan was designed only for the nature park “Daugavas loki” (2010–2022). The new protected Landscape nature protection plan (2023–2035) covers 52 098 ha, including the nature park “Daugavas loki”. The new protection plan presents the research results of EU habitat types, their quality, flora and fauna species lists, as well as the level of threats and challenges. Landscape planning, functional zonation and large programme of management activities are offered for Augšdaugava and Krāslava municipalities for the first time to promote tourism industry in future and protect the nature values. This area under UNESCO umbrella was nominated as mixed because of unique combination of nature, geology, long time history of different nations, their religion, culture. The nomination criteria are enriched both for nature and culture in a protection plan process, meaning that the scientific background is high and it is time to start the process to the nomination of the Upper Daugava and meanders to the UNESCO World Heritage list.
Husaini M. Hasan dan Konsep Islamic State dalam Konteks Sosial Politik Aceh
Authors: Bustami Bustami , Katimin Katimin , Harahap Elly Wanisyah 
Published: January 2024

This article explores the concept of an Islamic state in Aceh within a historical and political context. Utilizing qualitative methods that combine biographical studies and documentary analysis, the research focuses on the role of Husaini M. Hasan in the Aceh Merdeka Movement and his efforts to implement Islamic Sharia in Aceh. Tracing Aceh's history from the colonial era to the modern day, the article depicts how Aceh has strived to maintain its Islamic identity within the framework of the Republic of Indonesia. The study elucidates the relationship between Aceh's desire to implement Islamic Sharia and its aspirations for unique regional autonomy and national identity. This analysis reveals how political thought and Islamic ideology shape the social and political identity of Aceh and its interaction with Indonesia's national politics. The study concludes that the Islamic State in Aceh is not a concept of an independent nation but a form of special autonomy within the Republic of Indonesia, emphasizing the need for a holistic and contextual approach to understanding and addressing issues related to Islamic Sharia, politics, and social identity in Aceh.
Abstrak
Artikel ini mengeksplorasi konsep Islamic State di Aceh dalam konteks historis dan politik. Penelitian ini menggunakan metode kualitatif berbasis studi biografis dan analisis dokumenter, berfokus pada peran Husaini M. Hasan dalam Gerakan Aceh Merdeka dan perjuangannya untuk penerapan syariat Islam di Aceh. Artikel ini memaparkan bagaimana Aceh, sejak masa kolonial hingga era modern, telah berjuang mempertahankan identitas Islamnya dalam kerangka Negara Kesatuan Republik Indonesia. Dengan menganalisis berbagai wawancara dan dokumen, penelitian ini menunjukkan bagaimana keinginan Aceh untuk menerapkan syariat Islam berkaitan dengan aspirasinya untuk otonomi regional dan identitas nasional yang unik. Pemikiran politik dan ideologi Islam berperan dalam pembentukan identitas sosial dan politik Aceh, serta berinteraksi dengan politik nasional Indonesia. Kajian ini menyimpulkan bahwa Islamic State di Aceh bukanlah konsep negara merdeka, melainkan bentuk khusus otonomi dalam NKRI. Hal ini menunjukkan perlunya pendekatan yang lebih holistik dan kontekstual dalam memahami dan menangani isu-isu yang berkaitan dengan syariat Islam, politik, dan identitas sosial di Aceh.
Percepções sobre o desenvolvimento de atividade de Modelagem na Formação Inicial em Matemática: um relato
Authors: Silva Luana Lima da , De Moura Veloso Davi , Braga Souza Lahis 
Published: January 2024

O presente texto é um relato de experiência e tem por intuito apresentar as percepções de licenciandos em Matemática em dois primeiros desenvolvimentos de atividades de Modelagem Matemática. Tais percepções emergiram em cartas solicitadas pela docente em uma disciplina do curso de Licenciatura em Matemática da Universidade Federal do Acre, inspirada nas obras do Educador Paulo Freire, como meio de reflexão e valorização dos conhecimentos produzidos. Antes de apresentá-las, inicialmente, aborda-se o contexto de realização das atividades. Na sequência, apresenta-se a compreensão de Modelagem Matemática assumida e as percepções que surgiram ao se desenvolver uma atividade em dupla, com problematização proposta pela docente. Posteriormente, disserta-se sobre as percepções suscitadas ao realizarem uma atividade cujo tema para problematizar foi escolhido pelos participantes. Tais percepções evidenciam delimitações, ao longo da atividade, com um tema proposto pela docente; verificou-se que a escolha de um tema de interesse e a problematização são fatores dificultadores, visto que a autonomia não é algo que foi trabalhado no decorrer do processo formativo, pautado, principalmente, na memorização e na reprodução. Conjectura-se que seja necessário repensar a formação inicial em Matemática voltada a uma relação que envolva não apenas a teoria, mas também a prática com desenvolvimento de atividades de Modelagem, em um movimento indissociável entre as duas, teoria e prática, possibilitando que o licenciando vivencie o papel de aluno e reflita sobre o papel de futuro educador.