bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unravelling the Complex Interplay: Understanding Drug-induced Diseases
and Teratogenicity from a Comprehensive Perspective
Authors: Prakash Kartikay , Tiwari Shashank 
Published: January 2024

Abstract:
Iatrogenic diseases, also referred to as drug-induced diseases (DIDs), represent a recognized yet inadequately investigated phenomenon that may result in enduring afflictions, hospital admissions, pharmacological interventions, protracted pharmaceutical reliance, and health
complications. In the contemporary era of personalized medicine, it is imperative for prescribers
to remain abreast of the dynamic advancements in the field of toxicology. Iatrogenic disorders
may manifest as a result of medical interventions, including diagnostic procedures, therapeutic
interventions, or preventative measures. Key factors to be taken into consideration encompass
the patient's chronological age, dietary patterns, genetic predisposition, pre-existing medical
conditions, diminished host response mechanisms, and pharmacological tolerance. Teratogenicity pertains to the prevalence of congenital anomalies and disorders resulting from exposure to
teratogenic agents, environmental influences, and pharmacological interventions. The primary
objective of this review is to provide individuals with comprehensive knowledge regarding the
potential risks associated with iatrogenic diseases, thereby facilitating the prevention of unforeseen adverse outcomes.
A Novel DWT-ERT-based Fault Location for Distribution Network
Authors: Rahangdale Roshni , Gupta Archana 
Published: January 2024

Background:A new DWT-ERT-based fault location method is suggested in the IEEE test feeder.Objective:The fault location approach in the distribution network has been proposed in this pa-per that utilizes the discrete wavelet transform (DWT) and ensemble regression tree (ERT).Methods:The fault location methodology has been validated by simulations conducted on an IEEE 13 bus node test feeder.Results:The results show that the suggested solution has low compute burden and memory re-quirements, and is unaffected by system and fault situations.Conclusion:In this study, the fault location approach for the distribution system employing DWT and ERT has been proposed.
CNN-FastText Multi-Input (CFMI) Neural Networks for Social Media
Clickbait Classification
Authors: Sharma Chirag , Singh Gurneet , Muttum Pratibha Singh , Mahajan Shubham 
Published: January 2024

Introduction:
User-generated video portals, such as YouTube, are facing the chal-lenge of Clickbait. These are used to lure viewers and gain traffic on specific content. The real content inside the video deviates from its title. and a thumbnail. The consequence of this is poor user experience on the platform.

Methods:
The existing identification techniques either use pre-trained models or are restricted to text only. Other video metadata is not considered. To tackle this situation of clickbait, we propose a CNN-Fast Text Multi-Input (CFMI) Neural Network. The method employs a self-developed convolutional model, combined with different other video metadata. The thumbnail of any video plays a vital role in gathering user attention; hence, it should also be addressed. With greater expressiveness, it depicts and captures the parallels between the title and thumb-nail and the video content.

Results:
This research also compares the proposed system with the previous works on various parameters. With the usage of the proposed network, the platforms can easily analyze the vide-os during the uploading stage. The future belongs to Post Quantum Cryptography (PWC), we reviewed various encryption standards in this paper.

Conclusion:
In Industry 4.0, every data bit is crucial and must be preserved carefully. This in-dustry will surely benefit from the model as it will eliminate false and misleading videos from the platform.
In silico Evaluation of Anacyclus pyrethrum Composition for Inhibition of
Spike RBD-ACE-2 Interaction to Treat COVID-19
Authors: Pandey Anand Kumar , Awasthi Jayanti , Chaturvedi Kislay , Mishra Ayush , Yadav Shivangi , Rathore Soumya , Birwal Preeti 
Published: January 2024

Background:
The spike glycoprotein of SARS-CoV-2, via its S1-subunit, binds with host
angiotensin-converting enzyme 2 (ACE-2) receptors, and its S2-subunit mediates the fusion of the
virus to the host cell. The entry of SARS-CoV-2 inside the host cell can be prevented by inhibition of
the receptor binding domain (RBD) of S1-subunit of the spike. Anacyclus pyrethrum, a native herb
of Algeria, Spain and Morocco has antidepressant, analgesic, antimicrobial, anesthetic, antioxidant,
anti-inflammatory, aphrodisiac, antidiabetic and immunostimulant effects. Still, its antiviral effect
has not been established yet.

Methodology:
The present study deals with ADMET (Absorption, Distribution, Metabolism, Excretion
and Toxicity), molecular docking and molecular dynamic simulation based investigation to
evaluate the potential of Anacyclus pyrethrum constituents for effective spike RBD inhibition.

Results:
ADMET analysis revealed that 10 out of 12 significant constituents belongs to toxicity class
4 to 6 proving least toxicity of the plant extract with high LD50 values. Molecular docking analysis
of 10 considered compounds revealed that morphinan-6-one, 4,5.alpha.-epoxy-3-hydroxy-17-methyl,
a derivative of morphine (well-known analgesic and anti-inflammatory compound) gave the maximum
negative binding energy of -6.9Kcal/mol in best-docked conformation with spike RBD having
2 hydrogen bonds. Molecular dynamic simulation disclosed effective RMSD, RMSF, and Rg values
over the simulation trajectory with significant hydrogen bonding proving stable interaction of the
compound with that of the spike RBD.

Conclusion:
Hence, all these outcomes revealed the outstanding potential of the Anacyclus pyrethrum
extract to inhibit the spike RBD of SARS-CoV-2. Therefore, further in-vitro investigation can
develop natural and effective treatments against COVID-19 disease.
Therapeutic Significance of Cornin in Medicine for Their Biological Importance and Pharmacological Activity: An Overview of Iridoid Glycosides of Verbena Officinalis L.
Authors: Patel Kanika , Patel Dinesh Kumar 
Published: January 2024

Background:
Plant products have been used for the treatment of numerous kinds of
human disorders since the very ancient age. Iridoid glycosides are secondary plant metabolites of
medicinal importance that have been well investigated in the scientific field for their role in plants.
Numerous iridoid class phytochemicals have cardiovascular, anti-viral, anti-hepatotoxic, anti-inflammatory,
anti-cancer, immunomodulatory, anti-spasmodic, hypolipidemic, choleretic, purgative,
and hypoglycaemic activity.

Methods:
Here in the present work, we have collected scientific information on cornin and presented
it with respect to its medicinal importance and pharmacological activities with their analytical
aspects. Scientific information on cornin has been collected from numerous scientific databases
such as PubMed, Science Direct, Google, and Scopus to know the biological potential of
cornin in medicine. Further, pharmacological activity scientific data of cornin has been presented
in this work with proper citations.

Results:
The scientific data of the present paper described the biological significance of cornin in
medicine. The further detailed pharmacological activity of cornin signified its therapeutic effectiveness
on cerebral ischemia, angiogenesis, autophagy, myocardial injury, cerebral injury, oxidative
injury, lipid peroxidation, proliferation, and cytochrome p450. Analytical data signified the
separation, isolation, and identification techniques of cornin in medicine.

Conclusion:
The scientific information of the present work will be beneficial for all scientific
people to explore the therapeutic effectiveness of cornin in medicine.
Gender and Access to Justice in the Informal Court System in Ghana: A
Descriptive Phenomenology in a Patriarchal Society
Authors: Adongo Awinaba Amoah , Dapaah Jonathan Mensah , Azumah Francess Dufie 
Published: January 2024

Background:
Women and access to justice are global issues, especially in patriarchal
societies. There is a surprisingly small body of research on access to justice in the informal court
system in patriarchal societies. The purpose of this paper is to conduct an empirical qualitative
study on a local court case and use the findings to provide a critical analysis of women and access
to justice in the informal court setting in Ghana.

Method:
The exploratory qualitative research approach and phenomenological research design
were used in the study, which followed Colaizzi's process of descriptive phenomenological data
analysis. The study collected data from fifteen women who had used the informal court system to
address their grievances using in-depth interviews and focus group discussions as data collection
techniques. The data was collected via tape recording and then transcribed word for word.

Results:
The major themes that emerged from the research were as follows: (i) traditional gender
roles as impediments to justice (ii) social harmony-based adjudication, and (iii) the social consequences
of the court's decisions on the family households. Sub-themes are used to discuss these
major themes. According to the findings, women cooking and taking care of children, behavioural
socialisation norms, women as housewives, informal court decisions based on social harmony,
masculine rulings, lack of appeal for cases, women experiencing marital divorce, and lack of enforcement
for rulings were identified as significant factors influencing gender and access to justice
among women in the informal court system.

Conclusion:
Informal courts are accessible and affordable to women who do not have the privilege
of using formal courts due to the cost involved; however, the courts' decisions are reconciliatory
and do not provide women with equal access to justice. To provide fair justice to all people
in rural communities, the informal courts should be integrated with the formal procedure. As a
result of the findings, it is recommended that a comprehensive training programme for traditional
court judges on land issues, inheritance, and family law, dispute resolution, as well as international
human rights standards be implemented so they can handle cases in their respective jurisdictions.
Targeting Histamine and Histamine Receptors for Memory Regulation:
An Emotional Perspective
Authors: Fang Zhuowen , Chen Jiahui , Zheng Yanrong , Chen Zhong 
Published: January 2024

Abstract:
Histamine has long been accepted as a pro-cognitive agent. However, lines of evidence
have suggested that the roles of histamine in learning and memory processes are much more complex
than previously thought. When explained by the spatial perspectives, there are many contradictory results.
However, using emotional memory perspectives, we suspect that the histaminergic system may
interplay with stress, reward inhibition, and attention to modulate emotional memory formation. The
functional diversity of histamine makes it a viable target for clinical management of neuropsychiatric
disorders. Here, we update the current knowledge about the functions of histamine in emotional memory
and summarize the underlying molecular and neural circuit mechanisms. Finally, we review the main
clinical studies about the impacts of histamine-related compounds on memory and discuss insights into
future research on the roles of histamine in emotional memory. Despite the recent progress in histamine
research, the histaminergic emotional memory circuits are poorly understood, and it is also worth verifying
the functions of histamine receptors in a more spatiotemporally specific manner.
Astrocytes and Memory: Implications for the Treatment of
Memory-related Disorders
Authors: Wang Juan , Cheng Ping , Qu Yan , Zhu Guoqi 
Published: January 2024

:
Memory refers to the imprint accumulated in the brain by life experiences and represents
the basis for humans to engage in advanced psychological activities such as thinking and imagination.
Previously, research activities focused on memory have always targeted neurons. However, in addition
to neurons, astrocytes are also involved in the encoding, consolidation, and extinction of memory. In
particular, astrocytes are known to affect the recruitment and function of neurons at the level of local
synapses and brain networks. Moreover, the involvement of astrocytes in memory and memory-related
disorders, especially in Alzheimer’s disease (AD) and post-traumatic stress disorder (PTSD), has been
investigated extensively. In this review, we describe the unique contributions of astrocytes to synaptic
plasticity and neuronal networks and discuss the role of astrocytes in different types of memory processing.
In addition, we also explore the roles of astrocytes in the pathogenesis of memory-related disorders,
such as AD, brain aging, PTSD and addiction, thus suggesting that targeting astrocytes may
represent a potential strategy to treat memory-related neurological diseases. In conclusion, this review
emphasizes that thinking from the perspective of astrocytes will provide new ideas for the diagnosis
and therapy of memory-related neurological disorders.
Radiographic signs and hip pain 5 years after THA with a cemented stem predict future revision for aseptic loosening: a prospective cohort study
Authors: Lübbeke Anne , Barea Christophe , Zingg Matthieu , Lauper Nicolas , Hannouche Didier , Garavaglia Guido 
Published: January 2024

Background and purpose: We aimed to evaluate the long-term predictive value of radiographic abnormality and/or hip pain assessed 5 years following primary total hip arthroplasty (THA) and the occurrence of revision for aseptic loosening between 5 and 25 years postoperatively.Patients and methods: We included all primary THAs performed between 1996 and 2011 (same uncemented cup, polyethylene-ceramic bearing, 28 mm head, cemented stem) and prospectively enrolled in the institutional registry, for whom baseline and follow-up radiographs were available. At 5 years radiographically we assessed femoral osteolysis and/or stem migration. Pain was evaluated with the Harris Hip pain subscore. Kaplan–Meier survival and Cox regression analyses were performed.Results: 1,317 primary THAs were included. 25 THAs (2%) were revised for aseptic stem loosening. Any abnormal radiographic sign at 5 years was present in 191 THAs (14%). Occasional hip pain was reported by 20% and slight to severe pain by 12% of patients at 5 years. In patients < 60 years, 10 of the 12 later revised for aseptic stem loosening had abnormal radiographs at 5 years vs. 5 of the 13 later revised in those ≥ 60 years. Hazard ratios (HR) were 34 (95% confidence interval [CI] 7–155) in younger vs. 4 (CI 1–11) in the older group. HR for association of hip pain at 5 years with future revision was 3 (CI 1–5).Conclusion: The presence of abnormal radiographic signs 5 years after THA was strongly associated with later revision for aseptic stem loosening, especially in patients < 60 years. The association between pain at 5 years and future revision was much weaker.
Enhancement of nutraceutical components of mushroom by uv exposure and extension of their shelf-life using edible coating material adopting online assessment of keeping quality by Magnetic Resonance Imaging (MRI) technique
Authors: Tidke Shashank , B Pooja , B.V Manjula , Singh Roma , Shora R , HA Arush , S Sinosh , Geethanath Sairam , S Kiran , G.A Ravishankar 
Published: January 2024

To enhance the nutraceutical value and preservation of mushrooms, this study focused on augmenting two widely consumed mushroom varieties in India namely the Button Mushroom (Pleurotus ostreatus) and Oyster Mushroom (Agaricus bisporus). These mushrooms were subjected to UV light exposure to evaluate their impact on phytochemical content, including phenolics, flavonoids, folic acid, and Vitamin D2. The percent increase in phenolic content after 120 minutes of UV treatment was 0.6-fold for Agaricus bisporus and 0.7-fold for Pleurotus ostreatus. Notably, A. bisporus exhibited a particularly high phenolic content of up to 13.5 mg per gram dry weight of mushroom after 120 minutes of UV exposure, in contrast to P. ostreatus, which displayed 8.7 mg per gram dry weight of mushroom under the same conditions. This study also revealed a threefold increase in flavonoid content in Pleurotus ostreatus, rising from 1.2 mg of quercetin/g in the control to 4.1 mg of quercetin/g after UV exposure for 120 minutes. Conversely, a sevenfold increase in quercetin content was observed in Agaricus bisporus, surging from 0.45 g (control) to 3.2 g following 120 minutes of UV exposure. The exposure of UV light for 60 minutes resulted in the highest absorbance of vitamin D2 at 0.81 OD in Pleorotus osteatus compared to 0.46 in Agaricus bisporus. Additionally, applying agar or gelatine coatings led to a shelf-life extension of up to 14 days under standard storage conditions. The use of MRI for quality determination of mushrooms by evaluating the lipid profile in the samples was reported for the first time. This study has shown a significant enhancement of nutraceutical components of mushrooms with special reference to phenolics, flavonoids, folic acid, and vitamin D2 for value addition, with a simple intervention of UV treatment. Moreover, the shelf life of mushrooms could be enhanced by agar and gelatin coating thereby extending the keeping quality. The use of MRI for evaluating the quality of mushrooms has also been the hallmark of this study. The practical utility of all the above findings has immense industrial application in the large-scale production of highly nutritive mushrooms.
Source Code Features and their Dependencies: An Aggregative Statistical Analysis on Open-Source Java Software Systems
Authors: Toosi Farshad Ghassemi 
Published: January 2024

Abstract
Source code constitutes the static and human-readable component of a software system. It comprises an array of artifacts and features that collectively execute a specific set of tasks. Coding behaviours and patterns are formulated through the orchestrated utilization of distinct features in a specified sequence, fostering inter-dependencies among these features. This study seeks to explore into the presence of specific coding behaviours and patterns within Java, which could potentially unveil the extent to which developers endeavour to leverage the facilities and services that exist in the programming language aggregatively. In pursuit of investigating behaviours and patterns, 436 open-source Java projects are selected, each having more than 150 Java files (Classes and Interfaces), in a semi-randomized manner. For every project, 39 features have been chosen, and the frequency of each individual feature has been independently assessed. By employing linear regression, the interrelationships among all features across the complete array of projects are scrutinized. This analysis intends to uncover the manifestation of distinct coding behaviours and patterns. Based on the selected features, preliminary findings suggest a notable collective incorporation of diverse coding behaviours among programmers, encompassing Encapsulation and Polymorphism. The findings also point to a distinct preference for using a specific commenting mechanism, JavaDoc, and the potential existence of Code-Clone and dead code. Overall, the results indicate a clear tendency among programmers to strongly adhere to the fundamental principles of Object -Oriented programming. However, certain less obvious attributes of object-oriented languages appear to receive relatively less attention from programmers.
Value of four-dimensional computed tomography angiography combined with stromal cell-derived factor-1 for differentiating ruptured intracranial aneurysms and assessing risk of ruptures
Authors: Xu Yiming , Liao Chengde 
Published: January 2024

Abstract
Background: To analyze the value of four-dimensional computed tomography angiography (4D-CTA) combined with stromal cell-derived factor-1 (SDF-1) for differentiating ruptured intracranial aneurysms and assessing the risk of ruptures.
Methods: Fifty patients with unruptured intracranial aneurysms and 50 patients with ruptured ones were included in non-rupture group 1 and rupture group 1, respectively. All patients underwent 4D-CTA and 3D-CTA, and the serum SDF-1 level was detected. Non-rupture group 1 was followed up for 12 months. On this basis, the patients with ruptured aneurysms were included in rupture group 2 and those without ruptured aneurysms were assigned to non-rupture group 2.
Results: The AUC values of Wn, AR, L, SR, SDF-1 and their combination for the diagnosis of ruptured intracranial aneurysms were all >0.70, especially their combination. Wn, AR, L, and SR were higher in rupture group 2 than those in non-rupture group 2 (P<0.05). The level of SDF-1 in rupture group 2 [(142.48±11.23) μg/L] was higher than that in non-rupture group 2 [(128.03±10.28) μg/L] (P<0.05). Wn, AR, L, SR, and SDF-1 and their combination all had the AUC values of >0.70 for the prediction of ruptured intracranial aneurysms, especially their combination. The CT values of the internal carotid artery and middle cerebral artery and the CT value and noise of brain parenchyma in 4D-CTA were higher than those in 3D-CTA (P<0.05).
Conclusions: 4D-CTA combined with SDF-1 can effectively differentiate ruptured intracranial aneurysms and predict the risk of ruptures.
Challenges in prophylactic therapy with Emicizumab in patients with hemophilia A: Focus on monitoring tests
Authors: Brinza Melen , Uscatescu Valentina , Hemcinschi Mihai , Chiriac Elisabeta , Gherghe Georgiana , Coriu Daniel 
Published: January 2024

Abstract
This study presents a transversal investigation that we performed at Fundeni hospital (Bucharest, Romania) into the therapeutic benefits and efficacy of Emicizumab, a non-factor therapy, in the context of hemophilia A. Ten patients diagnosed with hemophilia A were closely monitored using clinical and laboratory resources during Emicizumab treatment, with an average of 12.8 months. Among these patients, six exhibited anti-factor VIII inhibitors, changing the medical strategy and adding complexity to their clinical profiles. A comprehensive approach was adopted to assess the coagulation status of patients under Emicizumab therapy. The study employed several key coagulation monitoring tools, including thrombin generation time (TGT) and thrombelastography (TEG). These methodologies generated valuable results in evaluating the patients’ coagulation profiles during the treatment regimen. Additionally, traditional coagulation assays were utilized to gain a profound understanding of the overall coagulation dynamics and to evaluate the therapeutic response. During prophylaxis with Emicizumab all patients experienced a reduced number of bleeding events. Moreover, a subset of these patients underwent major surgical procedures (orthopedic joint replacements, cholecystectomy) with successful outcomes. These findings underscore the potential of Emicizumab therapy as an effective option for hemophilia A patients, including those with inhibitors. Our research provides physicians several insights, offering a potential avenue for improved patients’ care and treatment strategies that translate in enhanced quality of life for hemophilia A patients undergoing Emicizumab therapy.