bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical performance of short 6‐mm implants supporting single crowns in the posterior region: A 10‐year cohort study
Authors: Bregagnol Raphaela Brambilla , Coltro Maria Paula de Lima , Villarinho Eduardo Aydos , Triches Diego Fernandes , Alonso Fernando Rizzo , Mezzomo Luís André Mendonça , de Macedo Bianca Brandelli , Teixeira Eduardo Rolim , Vigo Alvaro , Shinkai Rosemary Sadami Arai 
Published: October 2023

AbstractIntroductionLong‐term clinical success of non‐splinted, posterior, and short implants still is unclear. This prospective cohort study reports the 10‐year follow‐up of 6‐mm implants supporting single crowns in the posterior region, and patient‐reported outcomes.MethodsBaseline sample comprised 20 patients treated with 46 screw‐retained crowns supported by 6‐mm implants with moderately rough implant surface. Participants were recalled for a 10‐year clinical follow‐up to assess survival rates, biologic and mechanic conditions, quality of life (OHIP‐14), and treatment satisfaction. Data were collected with clinical‐radiographic exams and analyzed using descriptive and inferential statistics.ResultsFourteen patients with 35 implant‐crown units were examined after 127.6 ± 11.8 months. For the entire cohort period, 7/46 implants were lost (survival estimate: 77.7% at 133 months), and mechanic complications occurred in 14/46 units (survival estimate: 66.4% at 116 months). In the Cox models, “maximum occlusal force” had a significant effect for implant loss (p = 0.038) and for prosthetic screw loosening (p = 0.038); “arch” and “bruxism” were not significant. Peri‐implant bone loss was 0.4 ± 0.6 mm at 10 years. For peri‐implant bone level, “crown‐to‐implant ratio” (p < 0.001) and “time” (p = 0.001) were significant. Bone levels differed from baseline to 12, 48, and 120 months. Satisfaction VAS was 94.0 ± 7.9 mm and OHIP‐14 was 2.3 ± 2.2.ConclusionSingle screw‐retained crowns supported by 6‐mm implants have an acceptable long‐term clinical performance, with stable peri‐implant bone levels after 10 years of function.
Associations between patient factors and successful colon capsule endoscopy – A prospective cohort study
Authors: MacLeod C. , Foxton A. , Wilson P. , Treweek S. , Watson A. J. M. 
Published: October 2023

AbstractAimTo establish patient factors associated with a successful colon capsule endoscopy (CCE) test.MethodThis prospective cohort study used data collected from patients who underwent CCE as part of the ScotCap evaluation prior to April 2020. A CCE was defined as successful if the capsule visualized the whole colon and rectum (complete test) with sufficient bowel cleansing to permit assessment of the colonic mucosa (adequate bowel preparation). Factors from patients in symptomatic and surveillance groups were analysed for associations with a successful test, complete test, adequate bowel preparation and requirement for further procedure using univariate, multivariate logistic, least absolute shrinkage and selection operator regression.ResultsData from 263 symptomatic and 137 surveillance patients were analysed. There was an association between a symptomatic patient's age and a successful test (OR = 0.97, 95% CI: 0.95–0.99), adequate bowel preparation (OR = 0.97, 95% CI: 0.94–1.00) and further procedure requirement (OR = 1.04, 95% CI: 1.02–1.06). An association was found, for symptomatic patients, between a faecal immunochemical test result in the range 10–399 μg/g and a further procedure (OR = 2.32, 95% CI: 1.23–4.48). In patients undergoing surveillance for previous colorectal cancer (OR = 0.42, 95% CI: 0.18–0.97), had previous bowel resection surgery (OR = 0.43, 95% CI: 0.19–0.98) or took a beta blocker medication (OR = 0.32, 95% CI: 0.11–0.88), an association was found with further procedure requirement.ConclusionsAmong symptomatic patients, younger age was associated with obtaining a successful CCE test. Clinicians could consider patient selection based on these results to improve the rate of successful testing in clinical practice.
High sensitivity troponin I as a biomarker for cardiac allograft vasculopathy: Evaluation of diagnostic potential and clinical utility
Authors: Patel Krishan , Yadalam Adithya , DeStefano Robert , Desai Shivang , Almuwaqqat Zakaria , Ko Yi‐An , Alras Zahran , Martini Mohamed Afif , Ejaz Kiran , Alvi Zain , Varounis Christos , Murtagh Gillian , Gupta Divya , Book Wendy , Quyyumi Arshed A. 
Published: October 2023

AbstractIntroductionCardiac allograft vasculopathy (CAV) limits long‐term survival in heart transplant (HTx) recipients. The use of biomarkers in CAV surveillance has been studied, but none are used in clinical practice. The predictive value of high‐sensitivity troponin I (hsTnI) has not been extensively investigated in HTx recipients.MethodsHTx patients undergoing surveillance coronary angiograms and enrolled in the Emory Cardiovascular Biobank had plasma hsTnI measured. CAV grade was assessed using ISHLT nomenclature. Multivariable cumulative link mixed modeling was performed to determine association between hsTnI level and CAV grade. Patients were followed for adverse outcomes over a median 10‐year period. Kaplan‐Meier survival analysis and Cox proportional hazard modeling were performed.ResultsThree hundred and seventy‐two angiograms were analyzed in 156 patients at a median 8.9 years after transplant. hsTnI levels were positively correlated with concurrent CAV grade after adjustment for age, age at transplant, sex, BMI, hypertension, diabetes, hyperlipidemia, estimated glomerular filtration rate, and history of acute cellular rejection (p = .016). In an adjusted Cox proportional hazard model, initial hsTnI level above the median (4.9 pg/mL) remained a predictor of re‐transplantation or death (hazard ratio 1.82; 95% confidence interval 1.16–2.90; p = .01).ConclusionAn elevated hsTnI level reflects severity of CAV and is associated with poor long‐term outcomes in patients with HTx.
Impact of changes in skeletal muscle mass and quality during the waiting time on outcomes of lung transplantation
Authors: Hagiyama Akikazu , Sugimoto Seiichiro , Tanaka Shin , Matsubara Kei , Miyoshi Kentaroh , Katayama Yoshimi , Hamada Masanori , Senda Masuo , Toyooka Shinichi 
Published: October 2023

AbstractIntroductionThe association of changes in skeletal muscle mass and quality during the waiting time with outcomes of lung transplantation (LT) remains unclear. We aimed to examine the association of changes in skeletal muscle mass and quality during the waiting time, as well as preoperative skeletal muscle mass and quality, with outcomes of LT.MethodsThis study included individuals who underwent LT from brain‐dead donors. Skeletal muscle mass (cm2/m2) and quality (mean Hounsfield units [HU]) of the erector spinae muscle at the 12th thoracic level were evaluated using computed tomography. Preoperative skeletal muscle mass and quality, and their changes during the waiting time were calculated. We evaluated the associations among mechanical ventilation (MV) duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, 6‐minute walk distance at discharge, and 5‐year survival after LT.ResultsThis study included 98 patients. The median waiting time was 594.5 days (interquartile range [IQR], 355.0–913.0). The median changes in skeletal muscle mass and quality were −4.4% (IQR, −13.3–3.1) and −2.9% (IQR, −16.0–4.1), respectively. Severe low skeletal muscle mass at LT was associated with prolonged ICU LOS (B = 8.46, 95% confidence interval [CI]: .51–16.42) and hospital LOS (B = 36.00, 95% CI: 3.23–68.78). Pronounced decrease in skeletal muscle mass during the waiting time was associated with prolonged MV duration (B = 7.85, 95% CI: .89–14.81) and ICU LOS (B = 7.97, 95% CI: .83–15.10).ConclusionMaintaining or increasing skeletal muscle mass during the waiting time would be beneficial to improve the short‐term outcomes of LT.
Pharmacokinetic similarity of switching SAR341402 insulin aspart biosimilar and NovoLog insulin aspart versus continuous use of NovoLog in adults with type 1 diabetes: The GEMELLI X trial
Authors: Shah Viral N. , Al‐Karadsheh Amer , Barnes Cathy , Mandry Jose , Nakhle Samer , Wernicke‐Panten Karin , Kramer Daniel , Schmider Wolfgang , Pierre Suzanne , Teichert Lenore , Rotthaeuser Baerbel , Mukherjee Bhaswati , Bailey Timothy S. 
Published: October 2023

AbstractAimTo assess whether multiple switches between SAR341402 biosimilar insulin aspart (SAR‐Asp) and the insulin aspart reference product (NovoLog; NN‐Asp) leads to equivalent pharmacokinetic (PK) exposure compared with continuous use of NN‐Asp in adults with type 1 diabetes (T1D).Materials and MethodsThis multicentre, open‐label, phase 3 study randomized (1:1) 210 subjects with T1D treated with once‐daily insulin glargine U100 as basal insulin to four 4‐week periods of alternating multiple daily injections of SAR‐Asp and NN‐Asp (NN‐Asp for the first 4 weeks, SAR‐Asp in the last 4 weeks; switching group) versus 16 weeks of continuous NN‐Asp (non‐switching group). At week 16, a single dose (0.15 U/kg) of SAR‐Asp in the switching group (n = 95) or NN‐Asp in the non‐switching group (n = 105) was given in the morning before breakfast. Primary PK endpoints were area under the plasma concentration curve (AUC) and maximum plasma concentration (Cmax) of SAR‐Asp versus NN‐Asp after the single dose at week 16.ResultsThe extent of PK exposure was similar between the two treatments (SAR‐Asp in the switching group and NN‐Asp in the non‐switching group) at week 16, with point estimates of treatment ratios close to 1. The 90% confidence intervals for AUC treatment ratios were contained within 0.8‐1.25. For Cmax in the primary analysis set, the upper confidence limit was 1.32. This was because of the profiles of three participants with implausible high values. A prespecified sensitivity analysis excluding implausible values showed results contained within 0.8‐1.25.ConclusionsPK exposure of SAR‐Asp (switching group) and reference NN‐Asp (non‐switching group) were similar, supporting interchangeability between these two insulin aspart products.
Slowness as warfare: Towards a relational approach to political violence in the West Bank
Authors: Golańska Dorota 
Published: October 2023

AbstractEngaging with recent applications of the concept of slow violence to the ongoing political developments in the West Bank, this review article argues that the relational approach offered by feminist geopolitics facilitates the conception of slow violence and warfare as part of a single complex of violence. The article traces feminist geopolitics' contribution to research on geographies of slow violence on the one hand, and to the analyses produced within the fields of critical geopolitics and critical war studies on the other, exposing that scholarly work exploiting the relational approach generated within and across these areas of research enables a broader understanding of political violence's tangled operations. Based on the analysis of the recent scholarly engagement with slow violence in the West Bank, the article proposes that thinking of slowness as a form of warfare captures the complex entanglement of different modalities of violence as they materialize in specific spatio‐temporal circumstances. Moreover, such an approach contributes to the further reinvigoration of feminist geopolitics with insights generated within (settler) colonial studies.
The introduction of the CGRP monoclonal antibodies and their effect on the prescription patterns of chronic migraine preventive medications in a tertiary headache center: A retrospective, observational analysis
Authors: Moskatel Leon S. , Graber‐Naidich Anna , He Zihuai , Zhang Niushen 
Published: October 2023

AbstractObjectiveTo determine the effect of the introduction of the calcitonin gene–related peptide monoclonal antibodies (CGRP mAbs) in 2018 on the prescribing of older medications for the prevention of chronic migraine.BackgroundPrior to 2018, the preventive treatment of migraine borrowed from medications intended to treat other illnesses with the last medication, onabotulinumtoxinA, receiving Food and Drug Administration (FDA) approval for the prevention of chronic migraine in 2010. The FDA approval of three CGRP mAbs in 2018 provided the ideal natural experiment to assess how the introduction of these medications, and a fourth in 2020, affected the generally stable migraine preventive medications market.MethodsWe performed a retrospective cohort analysis using the aggregated de‐identified data of 6595 patients. The percentage of patients with chronic migraine who had been prescribed one of ten most prescribed oral preventive medications or onabotulinumtoxinA, or any of the four CGRP mAbs, were calculated relative to the total number of patients with chronic migraine who received a prescription for any medication from our clinic during the pre‐CGRP mAb years of 2015–2017 and post‐approval years of 2019–2021.ResultsWe observed a statistically significant decrease in the prescription of the top 10 most prescribed medications after the introduction of the CGRP mAbs overall (1456/3144, 46.3%, to 1995/4629, 43.1%, p = 0.001), as well as with most individual medications, including large decreases in verapamil (230/3144, 7.3%, to 125/4629, 2.7%; p < 0.001), the tricyclic antidepressants (494/3144, 15.7%, to 532/4629, 11.5%; p < 0.001), topiramate (566/3144, 18.0%, to 653/4629, 14.1%; p < 0.001), and onabotulinumtoxinA (861/3144, 27.4%, to 1134/4629, 24.5%; p = 0.001).ConclusionThe introduction of the CGRP mAbs during 2018 resulted in a decrease in utilization of most oral medications and onabotulinumtoxinA for the prevention of migraine. Future work should continue to observe how the prescription patterns of these medications evolve with time.
“A lot of work needs to be done”—Service provider perspectives of mental health services available to Croatia‐ and Bosnia‐born migrants
Authors: Karakas Gabriella , du Plooy Daniel R. 
Published: October 2023

AbstractResearch suggests that migrants have higher rates of mental health disorders but are less likely to access mental health services, which highlights both their vulnerability to mental illness and inequity in service provision. Despite being large and established culturally similar migrant cohorts in Australia, Croatians and Bosnians are invisible in mental health research. This qualitative study collected practice‐based evidence from eight mental health service providers who have had direct professional contact with these communities, in order to understand how they engage with services, barriers to uptake and provide suggestions for service improvements. Thematic analysis was used to identify themes across interviews, which were then compared against Yang and Hwang's Migrant Mental Health Service Utilisation Model. The study identified unique factors specific to Croatia‐ and Bosnia‐born migrants that impact how they engage with services, including mandated/prescribed services, religious resources, knowledge resources, referral pathways and procedures, and service provider competencies. This study will promote a better understanding of the limitations of the current mental health service offerings for Croatia‐ and Bosnia‐born migrants, making it significant to practitioners, mental health organizations, policymakers and the general public.
CD57 T cells associated with immunosenescence in adults living with HIV or AIDS
Authors: Elias Junior Erivaldo , Gubert Vanessa T. , Bonin‐Jacob Camila M. , Puga Marco Antonio M. , Gouveia Cláudia G. , Sichinel Angela H. , Tozetti Inês A. 
Published: October 2023

AbstractDespite the advancement of human immunodeficiency virus (HIV)‐related discoveries, new HIV infections still persist. With the advent of antiretroviral therapy, prognosis has migrated from acute to chronic HIV infection and inflammation, with the possibility of increased immune aging. We aimed to assess such immunosenescence by analysing CD27 and CD57 expression on the surface of T cells. This cross‐sectional study was conducted between 2017 and 2018 on people living with HIV/AIDS (PLWHA) who attended an outpatient clinic of the Infectious Diseases Service of a university hospital and a geriatric reference service in Brazil. A standardized interview was conducted, and venous peripheral blood was collected for flow cytometry analysis. To assess immunosenescence, we compared CD27 and CD57 expression on the surface of T cells between adult and elderly individuals without HIV and adult PLWHA. All results for cells in terminal senescent stages in adult PLWHA more closely resembled those of elderly than adult participants without HIV (p > 0.05). The presence of CD27+ cells did not differ statistically among the three study groups when comparing immunological responders (IR) and immunological non‐responders (INR); for the entire CD4+ T‐cell population (including CD4 + CD8+ and CD4 + CD8– cells), the median count (25–75th) was higher in the INR (79.6%) than the IR (68.0%) group. HIV‐infected individuals possessed a higher number of T lymphocytes with a molecular phenotype associated with immunosenescence, a lower proportion of T cells in the early stages of senescence (median 25–75th: 27.0%), and a higher proportion of T cells in the intermediate and final stages of senescence (median 25–75th: 16.1%) than adults without HIV (median 25–75th: 42.0% and 18.4%, respectively). Considering the higher number of senescent T lymphocytes, we observed in our PLWHA population—especially in the INR group (CD8CD57+ cells: 39.3% INR vs. 23.4% IR; CD4CD57+ cells: 44.0% INR vs. 27.7% IR)—may indicate a similar mortality risk phenotype from immune‐preventable diseases
Interview With Adrian Raftery
Authors: Alkema Leontine , Murphy Thomas Brendan , Raftery Adrian E. 
Published: October 2023

SummaryProfessor Adrian E. Raftery is the Boeing International Professor of Statistics and Sociology and an adjunct professor of Atmospheric Sciences at the University of Washington in Seattle. He was born in Dublin, Ireland, and obtained a BA in Mathematics (1976) and an MSc in Statistics and Operations Research (1977) at Trinity College Dublin. He obtained a doctorate in mathematical statistics in 1980 from the Université Pierre et Marie Curie in Paris, France, under the supervision of Paul Deheuvels. He was a lecturer in statistics at Trinity College Dublin from 1980 to 1986, and then an associate (1986–1990) and full (1990‐present) professor of statistics and sociology at the University of Washington. He was the founding Director of the Center for Statistics and Social Sciences (1999–2009). Professor Raftery has published over 200 articles in peer‐reviewed statistical, sociological and other journals. His research focuses on Bayesian model selection and Bayesian model averaging, model‐based clustering, inference for deterministic simulation models, and the development of new statistical methods for demography, sociology, and the environmental and health sciences. He is a member of the United States National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, an Honorary Member of the Royal Irish Academy, a member of the Washington State Academy of Sciences, a Fellow of the American Statistical Association, a Fellow of the Institute of Mathematical Statistics, and an elected Member of the Sociological Research Association. He has won the Population Association of America's Clifford C. Clogg Award, the American Sociological Association's Paul F. Lazarsfeld Award for Distinguished Contribution to Knowledge, the Jerome Sacks Award for Outstanding Cross‐Disciplinary Research from the National Institute of Statistical Sciences, the Parzen Prize for Statistical Innovation, and the Science Foundation Ireland St. Patrick's Day Medal. He is also a former Coordinating and Applications Editor of the Journal of the American Statistical Association and a former Editor of Sociological Methodology. He was identified as the world's most cited researcher in mathematics for the decade 1995–2005 by Thomson‐ISI. Thirty‐three students have obtained PhD's working under Raftery's supervision, of whom 21 hold or have held tenure‐track university faculty positions. He has over 150 academic descendants. This interview took place over two sessions in March 2023.
Selectivity of acaricides to Neoseiulus barkeri (Hughes) (Acari: Phytoseiidae)
Authors: Silva Daniel L. , Lima Jayrla E. D. , Souza Pedro V. L. , Melo José W. S. , de Morais Oliveira Jose Eudes , Lima Debora B. 
Published: October 2023

AbstractNeoseiulus barkeri Hughes has been used to control several pests, including the red palm mite, Raoiella indica Hirst. However, in some situations, the exclusive use of biocontrol agents is not sufficient to prevent the damage caused by pests. In these scenarios, the integration of chemical and biological controls is desired. For that purpose, the determination of selective acaricides, avoiding or reducing deleterious effects on the biological control agent is desirable. This study evaluated the lethal and sublethal effects of acaricides (abamectin, azadirachtin, fenpyroximate and pyridaben) on the predatory mite N. barkeri. We investigated the toxicity and selectivity of the acaricides and the survival, fertility, egg viability and instantaneous growth rate (ri) of N. barkeri exposed to acaricides. Additionally, we classified the acaricides according to the scale proposed by the International Organization for Biological Control (IOBC). Among the acaricides evaluated, abamectin was selective for N. barkeri because the estimated lethal concentration (LC50) for N. barkeri was higher than that for R. indica. None of the acaricides affected predator survival curves. However, azadirachtin and fenpyroximate reduced the average predator survival time. Pyridaben was the only acaricide that reduced the fertility of N. barkeri females and, consequently, their instantaneous growth rate (ri). All the acaricides affected the viability of N. barkeri eggs. Pyridaben was classified as moderately harmful, whereas other acaricides were classified as harmless.
Influence of visual acuity, manual dexterity and handgrip strength on oral and denture hygiene ability of non‐frail older people: Development of the Gerostomatological Assessment Battery
Authors: Nitschke Ina , Altan Aylin , Roth‐Kreissl Marion , Sobotta Bernhard A. J. , Jockusch Julia 
Published: October 2023

AbstractBackgroundDue to the heterogeneity of older people, it is difficult to identify reliable factors influencing oral health.ObjectiveThe aim was to illustrate the influence of visual acuity, manual dexterity, and handgrip strength on the oral and denture hygiene ability of older non‐frail people.MethodsIn a cross‐sectional study, conducted at a specialized dental clinic, at baseline, all participants received professional prophylaxis and instruction on daily oral and denture hygiene regimes for a 6‐week intervention period. Data on the Quigley and Hein modified plaque index (QHI), respectively, the Denture Hygiene Index (DHI), visual acuity, manual dexterity and handgrip strength in non‐frail participants (≥ 65 years) were collected. Recruitment was done within the clinic's patient clientele and within the staff (control cohort).ResultsWomen showed significantly better manual dexterity than men (Mann–Whitney U, p = .01), while women's mean handgrip strength was significantly lower (Mann–Whitney U, p < .01). Manual dexterity (Mann–Whitney U, p = .003) and handgrip strength (Mann–Whitney U, p = .052) were associated with age. However, visual acuity, manual dexterity and handgrip strength had no influence on oral or denture hygiene.ConclusionVisual acuity, manual dexterity and handgrip strength have no influence on oral and denture hygiene ability in older non‐frail people. Further studies should investigate whether these factors also have no influence on oral and denture hygiene in vulnerable older patients. Therefore, an assessment tool for the evaluation of potential influencing factors of oral and denture hygiene is proposed in a dental context. This Gerostomatological Assessment Battery (G‐AB) can be used as a helpful tool to check the individual cognitive function and comprehension, dental therapy approaches and their individual adaption.