bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cobalt-60 Treatment Dose Rate on Arteriovenous Malformation Obliteration After Stereotactic Radiosurgery With Gamma Knife
Authors: Anthes Victoria B. , Schwartz Michael , Cusimano Michael , Radovanovic Ivan , Kulkarni Abhaya V. , Laperriere Normand , Payne David , Heaton Robert , van Prooijen Monique , Das Sunit , Tsang Derek S. 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Stereotactic radiosurgery (SRS) marginal dose is associated with successful obliteration of cerebral arteriovenous malformations (AVM). SRS dose rate—how old the cobalt-60 sources are—is known to influence outcomes for some neurological conditions and benign tumors. The objective of this study was to determine the association between cobalt-60 treatment dose rate and cerebral AVM obliteration in patients treated with SRS.

METHODS:
We performed a retrospective cohort study of 361 patients undergoing 411 AVM-directed SRS treatments between 2005 and 2019 at a single institution. Lesion characteristics, SRS details, obliteration dates, and post-treatment toxicities were recorded. Univariate and multivariate regression analyses of AVM outcomes regarding SRS dose rate (range 1.3-3.7 Gy, mean = 2.4 Gy, median = 2.5 Gy) were performed.

RESULTS:
At 10 years post-SRS, 68% of AVMs were obliterated on follow-up imaging. Dose rates >2.9 Gy/min were found to be significantly associated with AVM obliteration compared with those <2.1 Gy/min (P = .034). AVM size, biologically effective dose, and SRS marginal dose were also associated with obliteration, with obliteration more likely for smaller lesions, higher biologically effective dose, and higher marginal dose. Higher dose rates were not associated with the development of post-SRS radiological or symptomatic edema, although larger AVM volume was associated with both types of edema.

CONCLUSION:
Patients with cerebral AVMs treated with higher SRS dose rates (from newer cobalt-60 sources) experience higher incidences of obliteration without a significant change in the risk of post-treatment edema.
Chinese Neurosurgical Randomized Controlled Trials: Dynamics in Trial Implementation and Completion
Authors: Liu Tao , Liu Mingqi , Sha Zhuang , Wu Chenrui , Zhao Zhihao , Yuan Jiangyuan , Feng Dongyi , Nie Meng , Jiang Rongcai 
Published: October 2023

BACKGROUND AND OBJECTIVES:
The focus on evidence-based neurosurgery has led to a considerable amount of neurosurgical evidence based on randomized controlled trials (RCTs) being published. Nevertheless, there has been no systematic appraisal of China's contribution to RCTs. Information about the changes in characteristics of Chinese neurosurgical RCTs before and during the COVID-19 pandemic is limited. This study aims to perform a detailed examination and comprehensive analysis of the characteristics of Chinese neurosurgical RCTs and to examine the differences before and during the COVID-19 pandemic.

METHODS:
We conducted a comprehensive database search including PubMed, Web of Science, Embase, and Cochrane Library up to March 2023, with a criterion of inclusion based on an impact factor above 0. We subsequently examined the design and quality parameters of the included RCTs and assessed the differences before and during the COVID-19 pandemic (based on follow-up ending before or after January 2020). Moreover, we investigated potential factors that may affect the quality and developmental trends of neurosurgical RCTs in China.

RESULTS:
The main focus of the 91 neurosurgical RCTs was vascular disease (47.3%) and trauma (18.7%). Over half of the trials used Consolidated Standards of Reporting Trial diagrams (69.2%), and the majority compared nonsurgical treatments (63.7%). Larger trials tended to have better quality scores, but those with significant efficacy were less likely to have power calculations. Over time, there was an increase in the use of Consolidated Standards of Reporting Trial diagrams and well-specified outcomes. The COVID-19 pandemic may have hindered the completion of neurosurgical RCTs in China, but it has had little impact on the design and quality so far.

CONCLUSION:
Chinese neurosurgeons have made significant progress in advancing neurosurgical RCTs despite challenges. However, shortcomings in sample size and power calculation need attention. Improving the rigor, rationality, and completeness of neurosurgical RCT design is crucial.
Neurological Surgery Residency Programs in the United States: A National Cross-Sectional Survey
Authors: Ng Patrick R. , Yearley Alexander G. , Eatz Tiffany A. , Ajmera Sonia , West Timothy , Razak Shahaan S. , Lazaro Tyler , Urakov Timur , Jones Pamela S. , Coumans Jean-Valery , Stapleton Christopher J. , Shankar Ganesh , Chen H. Isaac , Komotar Ricardo J. , Patel Akash J. , Nahed Brian V. 
Published: October 2023

BACKGROUND AND OBJECTIVES:
The Accreditation Council for Graduate Medical Education has approved 117 neurological surgery residency programs which develop and educate neurosurgical trainees. We present the current landscape of neurosurgical training in the United States by examining multiple aspects of neurological surgery residencies in the 2022–2023 academic year and investigate the impact of program structure on resident academic productivity.

METHODS:
Demographic data were collected from publicly available websites and reports from the National Resident Match Program. A 34-question survey was circulated by e-mail to program directors to assess multiple features of neurological surgery residency programs, including curricular structure, fellowship availability, recent program changes, graduation requirements, and resources supporting career development. Mean resident productivity by program was collected from the literature.

RESULTS:
Across all 117 programs, there was a median of 2.0 (range 1.0-4.0) resident positions per year and 1.0 (range 0.0-2.0) research/elective years. Programs offered a median of 1.0 (range 0.0-7.0) Committee on Advanced Subspecialty Training–accredited fellowships, with endovascular fellowships being most frequently offered (53.8%). The survey response rate was 75/117 (64.1%). Of survey respondents, the median number of clinical sites was 3.0 (range 1.0-6.0). Almost half of programs surveyed (46.7%) reported funding mechanisms for residents, including R25, T32, and other in-house grants. Residents received a median academic stipend of $1000 (range $0-$10 000) per year. Nearly all programs (93.3%) supported wellness activities for residents, which most frequently occurred quarterly (46.7%). Annual academic stipend size was the only significant predictor of resident academic productivity (R2 = 0.17, P = .002).

CONCLUSION:
Neurological surgery residency programs successfully train the next generation of neurosurgeons focusing on education, clinical training, case numbers, and milestones. These programs offer trainees the chance to tailor their career trajectories within residency, creating a rewarding and personalized experience that aligns with their career aspirations.
Mapping oto-pharyngeal development in a human inner ear organoid model
Authors: Steinhart Matthew R. , van der Valk Wouter H. , Osorio Daniel , Serdy Sara A. , Zhang Jingyuan , Nist-Lund Carl , Kim Jin , Moncada-Reid Cynthia , Sun Liang , Lee Jiyoon , Koehler Karl R. 
Published: October 2023

ABSTRACT
Inner ear development requires the coordination of cell types from distinct epithelial, mesenchymal and neuronal lineages. Although we have learned much from animal models, many details about human inner ear development remain elusive. We recently developed an in vitro model of human inner ear organogenesis using pluripotent stem cells in a 3D culture, fostering the growth of a sensorineural circuit, including hair cells and neurons. Despite previously characterizing some cell types, many remain undefined. This study aimed to chart the in vitro development timeline of the inner ear organoid to understand the mechanisms at play. Using single-cell RNA sequencing at ten stages during the first 36 days of differentiation, we tracked the evolution from pluripotency to various ear cell types after exposure to specific signaling modulators. Our findings showcase gene expression that influences differentiation, identifying a plethora of ectodermal and mesenchymal cell types. We also discern aspects of the organoid model consistent with in vivo development, while highlighting potential discrepancies. Our study establishes the Inner Ear Organoid Developmental Atlas (IODA), offering deeper insights into human biology and improving inner ear tissue differentiation.
Effects of Different Weekly Set Progressions on Muscular Adaptations in Trained Males: Is there a Dose-Response Effect?
Authors: Enes Alysson , De Souza Eduardo O. , Souza-Junior Tácito P. 
Published: October 2023

ABSTRACT

Purpose
This study investigated the effect of progressively adding sets for the lower- limb every two weeks versus performing a constant set volume in resistance-trained males.

Methods
Thirty-one resistance-trained males (age 24.4 ± 2.9 years; height 175.5 ± 6.5 cm; body mass 80.1 ± 9.4 kg; body fat 14.4 ± 3.1%; resistance training [RT] experience 5.1 ± 2.2 years; one repetition maximum (1-RM) barbell back squat:body mass ratio 1.7 ± 0.1 a.u.) were randomly allocated into a Constant Group (CG, n = 10), a four sets progression group (4SG, n = 10) or a six sets progression group (6SG, n = 11). After a 2-week washout period and another 2-week familiarization period, participants performed a lower-limb training program twice a week for 12 weeks. Maximum dynamic strength (1-RM) in the barbell back squat, vastus lateralis cross-sectional area (CSA), and the sum of lateral thigh muscle thickness (∑MT) at 30, 50 and 70% of the femur length were assessed at baseline and after the 12-week training program.

Results
Regarding 1-RM, multiple comparisons revealed that 6SG elicited higher muscle strength gains than 4SG (p = 0.002) and CG (p < 0.0001), and 4SG had greater improvements than CG (p = 0.023). CSA and ∑MT showed no between-group differences (p = 0.067 and p = 0.076, respectively). However, an inspection of 95% confidence intervals suggests a potential dose-response relationship, with results appearing to plateau in the higher volume conditions.

Conclusions
Our results suggest that progressively adding four or six sets per week every two weeks elicited greater lower-limb strength in resistance-trained individuals over a 12-week training period. While our findings indicate a possible small benefit for higher volume conditions regarding hypertrophic adaptations in this population, the limited certainty of our findings warrants caution.
Impact of brand equity and service quality on the reputation of universities and students’ intention to choose them: The case of IIUM and UIN
Authors: Rizard Sylvia Rozza , Waluyo Bambang , Jaswir Irwandi 
Published: October 2023

Background:Numerous studies have been carried out on the impacts of brand equity and service quality of higher education institutions (HEIs) on their reputation and students’ satisfaction. This research aimed to compare the impact of brand equity and service quality on universities’ reputations, namely Universitas Islam Negeri (UIN) in Indonesia and International Islamic University Malaysia (IIUM) in Malaysia, and Indonesian students’ intention to choose the universities, which is moderated by study expense (price). UIN and IIUM are HEIs with a similar university concept, and Indonesian students have recently shown a high interest in them. The two universities have faculties not only in the field of Islamic studies but in general fields of studies as well, which are usually held by non-Islamic Universities. Therefore, their competitiveness against non-Islamic universities, especially the University of Indonesia (UI) has increased.Methods:The statistical measurement tool used was structural equation modeling (SEM). The number of items stated in the questionnaire was 45. Therefore, minimum data to be collected were 5 × 45 or 225 which rounded up to 228 from Indonesian students at UIN and IIUM (114 UIN students, and 114 Indonesian student respondents from IIUM).Results:The study results show that the universities’ reputations are strongly affected by their brand equity and service quality, which then affect students’ intention to choose the universities. Students had a higher intention to choose IIUM than UIN. The limitation of this research is that the effect of study expense on the intention of Indonesian students to study at UIN or IIUM has not yet been conducted. It will be conducted in the next study.Conclusions:These results are expected to be useful to UIN, IIUM, and especially Politeknik Negeri Jakarta (PNJ) in determining a strategy to enhance their reputations and the intention of Indonesian students to study there.
Treatment of acute sub-massive pulmonary embolism with balloon angioplasty and thrombolysis simultaneously
Authors: Arokiaraj Mark Christopher 
Published: October 2023

Background: Acute sub-massive pulmonary embolism is a common clinical condition, and it is associated with high mortality and morbidity. This condition is commonly associated with various co-morbidities and clinical circumstances. Methods: This is a case report series of 4 patients, wherein the thrombolysis and balloon angioplasty was performed simultaneously using a Cordis 6F diagnostic catheter and later exchanged with a 6F guide catheter in the respective pulmonary artery when a larger balloon was required. Results: All these four patients achieved successful revascularization of the respective pulmonary artery. One patient expired 30 hours after the procedure with a significant reduction in the symptoms suddenly, which was likely a second episode of pulmonary embolism. No bleeding manifestations were observed in any of the patients. The other three patients are on follow-up. Conclusion: Simultaneous coronary balloon dilatation and thrombolysis is a useful method in the treatment of sub-massive acute pulmonary embolism. If needed, higher caliber balloons can be used for the same technique using guide catheters.
Determining current approaches to the evaluation of the quality of healthcare simulation-based education provision: a scoping review.
Authors: Pogson Rachel , Henderson Helen , Holland Matt , Sumera Agnieszka , Sumera Kacper , Webster Carl A. 
Published: October 2023

Background: With an increase in simulation being used in healthcare education, there is a need to ensure the quality of simulation-based education is high. This scoping review was conducted to answer the question: What are the current approaches to the evaluation of the quality of health-care simulation-based education provision? Methods: Databases PubMed, Cochrane, ERIC, CINAHL and Medline were searched in March 2023 to retrieve peer-reviewed healthcare research and review articles written in the English language within the last 20 years. All data were extracted from six studies, themed and presented in the main text and in tabular form. Results: Two scoping reviews, one systematic review and three research articles were included. Three main themes were found: adherence to existing design frameworks, lack of validation of these frameworks and lack of evaluation frameworks, and a proposed evaluation framework. Many of the excluded articles focussed on gaining participant feedback to evaluate simulation activities, rather than evaluating the quality of the design and implementation of the simulation. Conclusions: Benchmarking of current United Kingdom (UK) healthcare simulation against UK and international simulation standards is required to increase its quality, therefore, an agreed UK template framework to evaluate simulation packages is recommended.
Routing Replenishment Workers: The Prize Collecting Traveling Salesman Problem in Scattered Storage Warehouses
Authors: Bock Stefan , Boysen Nils 
Published: October 2023

Many online retailers apply scattered (or mixed-shelves) storage in the picking areas of their warehouses. Instead of keeping unit loads together, individual pieces of stock keeping units (SKUs) are stored on various shelves throughout the warehouse. This storage strategy increases the probability that—whatever it is that customers order jointly—somewhere in the warehouse these products will be located in close proximity. Hence, a picker can retrieve them without excessive unproductive walking. The price for this advantage on the picking side, however, is additional effort for the replenishment workers (also denoted as stowers) when restocking the shelves. Instead of moving only a single homogeneous unit load toward an SKU’s designated storage position, each stower has to travel along multiple open shelf spaces until all products on the cart are stored on shelves. The resulting stower routing problem is equivalent to the well-known prize collecting traveling salesman problem (PCTSP). While the PCTSP for general graphs is known to be strongly [Formula: see text]-hard, we show that in a warehousing environment, where all open storage positions are located along parallel aisles, it is only binary [Formula: see text]-hard. The special parallel-aisle structure allows us to derive an exact solution algorithm with pseudo-polynomial runtime, which solves even instances with hundreds of open storage positions to proven optimality in just a few seconds. Our computational tests show that the performance gains of an optimized stowing process over the status quo, where stowers operate without decision support, are significant. Especially, when the fill level of a warehouse is high, directing stowers on optimized routes promises huge improvements. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms – Discrete. Funding: This work was supported by the German Science Foundation/Deutsche Forschungsgemeinschaft (DFG) by the grant “Routing of human and automated order pickers in modern warehouses” (BO 3148/14-1 and BO 1972/2-1). Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoc.2022.0173 .
Group Equality in Adaptive Submodular Maximization
Authors: Tang Shaojie , Yuan Jing 
Published: October 2023

In this paper, we study the classic submodular maximization problem subject to a group equality constraint under both nonadaptive and adaptive settings. It is shown that the utility function of many machine learning applications, including data summarization, influence maximization in social networks, and personalized recommendation, satisfies the property of submodularity. Hence, maximizing a submodular function subject to various constraints can be found at the heart of many of those applications. On a high level, submodular maximization aims to select a group of most representative items (e.g., data points). However, the design of most existing algorithms does not incorporate the fairness constraint, leading to underrepresentation or overrepresentation of some particular groups. This motivates us to study the submodular maximization problem with group equality, in which we aim to select a group of items to maximize a (possibly nonmonotone) submodular utility function subject to a group equality constraint. To this end, we develop the first constant-factor approximation algorithm for this problem. The design of our algorithm is robust enough to be extended to solving the submodular maximization problem under a more complicated adaptive setting. Moreover, we further extend our study to incorporating a global cardinality constraint and other fairness notations. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Supplemental Material: The online supplement is available at https://doi.org/10.1287/ijoc.2022.0384 .
Betting on Diversity—Occupational Segregation and Gender Stereotypes
Authors: Fischbacher Urs , Kübler Dorothea , Stüber Robert 
Published: October 2023

Gender segregation of occupations and entire industries is widespread. The segregation could be the result of perceived job-specific productivity differences between men and women. It could also result from the belief that homogeneous teams perform better or from in-group bias of male or female recruiters. We investigate these explanations in two samples: students and personnel managers. The subjects bet on the productivity of teams that are homogeneous with respect to gender at the outset and then either remain homogeneous or become diverse. The teams work on tasks that differ with respect to gender stereotypes. We obtain similar results in both samples. Women are picked more often for the stereotypically female task, and men are picked more often for the stereotypically male task. Subjects believe that gender-diverse teams perform better, especially in the task with complementarities, and they display an own-gender bias. Elicited expectations about the bets of others reveal that subjects expect the gender stereotypes of tasks but underestimate others’ bets on diversity. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: The authors acknowledge financial support from the Deutsche Forschungsgemeinschaft [Excellence Cluster EXC 2035/1 “The Politics of Inequality” (to U. Fischbacher), CRC TRR 190 “Rationality and Competition” (to D. Kübler), and the Excellence Cluster EXC 2055 “Contestations of the Liberal Script” (to D. Kübler)] and from Tamkeen [NYU Abu Dhabi Research Institute Award CG005 (to R. Stüber)]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4943 .
Determinants of podoconiosis among residents of Machakle District East Gojjam Zone Amhara Region Ethiopia
Authors: Tefera Teshome , Bogale Kassawmar Angaw , Tegegn Yiteka , Azene Abebaw Gedef , Mulatu Kebadnew , Wassie Gizachew Tadesse 
Published: October 2023

Background
Podoconiosis (endemic non-filarial elephantiasis) is a chronic disease characterized by the development of persistent swelling of plantar foot initially; which progresses to the dorsal foot and lower leg slowly or in a number of acute episodes to reach the knee. About 4 million people are said to be affected by the disease worldwide and it is deemed a serious public health problem in at least 10 African countries including Ethiopia. Therefore this study aimed to identify the determinants of podoconiosis among residence in Machakel district.

Method
Unmatched case control study design was conducted at Machakel district from August 30 to September 30, 2022. The sample size calculated using Epi-info software yielded 211 controls and 106 cases (317 study participants). Simple random sampling technique was used to select the cases using registration books of the district. Data were entered to Epi info version 7 and exported to SPSS version 22 for statistical analysis. Binary logistic regression was used to identify explanatory variables.

Result
A total of 312 study participants (104 cases and 208 controls) were included giving a response rate of 98.42%. Bare foot (AOR, 5.83 [95% CI: 2.34–14.50]), female sex (AOR, 4.25 [95% CI: 2.22–8.14]), family history of podoconiosis (AOR: 3.01(95% CI: 1.41–6.42) and age group 41–60 (AOR: 5.05(95% CI: 2.35–10.83), and 61–80 AOR 15.74 95% CI: (5.56–44.55) were determinants of Podoconiosis.

Conclusion and recommendation
Barefoot, sex, family history of podoconiosis and age were determinants of Podoconiosis. District health office should encourage at risk populations especially older people and individuals with family history of podoconiosis about shoe wearing practice all the time and not to expose their skin and feet.