bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Extended Sinus Surgery for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps, the Choice of Mucoplasty: A Systematic Review
Authors: Martin-Jimenez Daniel , Moreno-Luna Ramon , Cuvillo Alfonso , Gonzalez-Garcia Jaime , Maza-Solano Juan , Sanchez-Gomez Serafin 
Published: November 2023

Abstract
Purpose of Review
The advances in the knowledge of the molecular basis of the inflammatory response in chronic rhinosinusitis with nasal polyps (CRSwNP) have led the management of these patients towards personalized and precision medicine. Surgery has been positioned as a suitable alternative in patients who do not achieve control with appropriate medical treatment, but polypoid recurrences remain a constraint. The emergence of new surgical approaches based on patient phenotyping and the poor disease control associated with type 2 inflammatory phenotype makes it necessary to review the role of personalized and precision surgery in managing the disease.

Recent Findings
Surgical approaches based on wide resection of bony sinus structures and the treatment of mucosa lining the sinonasal cavity have been analyzed and compared with other techniques and seem to offer more favorable surgical outcomes and improved quality of life (QoL), in addition to lower relapse rates. The innovations with new complementary surgical techniques, such as reboot surgery adding an extended autologous mucosal graft from the nasal floor (mucoplasty), may benefit endoscopic and QoL outcomes in the most severe CRSwNP patients with type 2 phenotype.

Summary
Using bilateral endonasal mucoplasty as a complementary technique to reboot surgery is a suitable technical choice that has improved short- and medium-term QoL and endoscopic outcomes for patients with severe CRSwNP. These results are likely due to a combination of the extension of reboot and the inherent inflammatory and healing properties of mucoplasty. We propose this technique as a valuable surgical resource, although more robust clinical studies are needed to evaluate its long-term benefits comprehensively.
MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model
Authors: Liu Chang , Wang Yang , Li Jing-wen , Zhu Xiaoyan , Jiang Hai-song , Zhao Hong , Zhang Li-ming 
Published: November 2023

AbstractExosomes are nanoscale small vesicles (EVs) secreted by cells that carry important bio information, including proteins, miRNAs, and more. Exosome contents are readily present in body fluids, including blood, and urine of humans and animals, and thereby act as markers of diseases. In patients with Parkinson’s disease (PD), exosomes may spread alpha-synuclein and miR-184 between the cells contributing to dopaminergic neuronal loss. In this study, we detected the levels of miR-184 in urine-excreted neuronal exosomes between PD patients and age-matched healthy subjects by qRT-PCR analysis. Transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA) were also used to determine the ultracellular structures of exosomes nanoparticles. MPP + and MPTP were used to construct the cell and animal PD model. Behavioral tests were used to detect motor performance. Furthermore, the cytological experiments were measured to examine the relationship between miR-184 and ZNF865. We found that the levels of miR-184 in urine-derived neuronal exosomes from PD patients were higher, compared to aged-matched normal people. The exosomes from PD patients were larger with greater numbers than those from the age-matched healthy subjects. The difference in miR-184 in urinary exosomes between PD patients and normal people may provide a novel perspective for early diagnosis of PD. However, no difference in CD63 level was observed in Exo-control and Exo-PD groups (exosome from control or PD groups). Moreover, ZNF865 was detected as the targeted gene of miR-184. In addition, miR-184 ASO (miR-184 antisense oligodeoxynucleotide, miR-184 ASO) could rescue the damage of neuronal apoptosis and motor performance in PD mice. Our results showed the miR-184 potential to function as a diagnostic marker of PD.
Graphical Abstract
Erziehung in institutionellen Kontexten
Authors: Marks Svenja 
Published: November 2023

ZusammenfassungInnerhalb einer Gesellschaft ist das Zusammenleben mitunter über unterschiedliche, teilweise miteinander konkurrierende Lebensformen und darin eingelagerte Sinnsysteme (was das „Richtige“ oder „Gute“ sei) arrangiert. In dieser Perspektive hat Erziehung etwas damit zu tun, die Novizen (Kinder, aber auch ‚Fremde‘) in eben jenes „richtige“ oder „gute“ Leben einzuführen. Somit ist Erziehung niemals neutral, sondern mit ihrem Rekurs auf Lebensformen ist sie hochgradig normativ. Mit dieser Perspektive werden Erziehungsprozesse in Institutionen untersucht, in diesem Beitrag am Beispiel Schule.
Breaking the Taboo: Determinants of Sexual Knowledge and Attitudes Among Egyptian Women
Authors: Shousha Nayera Mohamed 
Published: November 2023

AbstractDrawing on 32 semi structured in-depth interviews with Egyptian women, this paper discusses determinants of sexual knowledge and attitudes among premarital and married women and women's agency in presenting sexual desires and gaining sexual knowledge in Egypt. Three main themes emerged as follows: (1) Attitudes toward being sexually educated; the findings show that most women have a positive attitude toward sexual knowledge and being sexually educated. However, there is still some embarrassment and shame associated with expressing their sexual needs or seeking more information about them. (2) Gender inequity in sexual knowledge: respondents have reported that they face social oppression and challenges when expressing their sexual desires, and there is gender inequity in obtaining knowledge about sex. Additionally, women agreed that men have the right to obtain knowledge about sex and that Egyptian society supports men in acquiring such knowledge. (3) General knowledge about sex; the internet is the most common source of information about sex. There is agreement that intimate relationships should be an enjoyable experience for both partners. Furthermore, women have stated that there are some indicators of successful sexual relationships. The current research contributes by filling a gap in the knowledge about women’s sexual education in Egypt, where empirical literature on women’s sexual knowledge in such conservative culture is lacking.
Tinten für die Biofabrikation–Druckbarkeit vs. Biokompatibilität?
Authors: Kuth Sonja , Lorke Markus , Frischknecht Renato , Boccaccini Aldo R. 
Published: November 2023

AbstractIn biomaterial ink development, achieving optimal performance is a complex process. A biomaterial ink that shows excellent printability may be inferior in terms of cell compatibility. Properties facilitating printability of biomaterial inks include, among others, viscosity and stiffness. Research shows that stiffness plays a pivotal role in dictating cell response. Neurons used in this study require an exceptionally low matrix stiffness, which may not show best printability results when realized in a biomaterial ink.
Modellierung der Bauchspeicheldrüse aus hPS-Zellen
Authors: Merz Sarah , Kleger Alexander 
Published: November 2023

AbstractHuman pluripotent stem cells can be differentiated into the pancreatic lineage, providing a human pancreas model to study diseases and development. We improved the differentiation protocol to generate pancreatic progenitors, the common ancestor of the endocrine and exocrine pancreas. We classified the glycoprotein-2 high-expressing subpopulation as truly multipotent, thereby making it particularly suitable to engineer acinar cells. Its capability of developing simultaneously into endocrine, ductal and acinar lineages qualifies it as a useful tool for pancreatic disease modelling.
An online surrogate-assisted neighborhood search algorithm based on deep neural network for thermal layout optimization
Authors: Zhao Jiliang , Wang Handing , Yao Wen , Peng Wei , Gong Zhiqiang 
Published: November 2023

AbstractThermal layout optimization problems are common in integrated circuit design, where a large number of electronic components are placed on the layout, and a low temperature (i.e., high efficiency) is achieved by optimizing the positions of the electronic components. The operating temperature value of the layout is obtained by measuring the temperature field from the expensive simulation. Based on this, the thermal layout optimization problem can be viewed as an expensive combinatorial optimization problem. In order to reduce the evaluation cost, surrogate models have been widely used to replace the expensive simulations in the optimization process. However, facing the discrete decision space in thermal layout problems, generic surrogate models have large prediction errors, leading to a wrong guidance of the optimization direction. In this work, the layout scheme and its temperature field are represented by images whose relation can be well approximated by a deep neural network. Therefore, we propose an online deep surrogate-assisted optimization algorithm for thermal layout optimization. First, the iterative local search is developed to explore the discrete decision space to generate new layout schemes. Then, we design a deep neural network to build an image-to-image mapping model between the layout and the temperature field as the approximated evaluation. The operating temperature of the layout can be measured by the temperature field predicted by the mapping model. Finally, a segmented fusion model management strategy is proposed to online updates the parameters of the network. The experimental results on three kinds of layout datasets demonstrate the effectiveness of our proposed algorithm, especially when the required computational budget is limited.
Indoor replication of outdoor climbing routes: fidelity analysis of digital manufacturing workflow
Authors: Bacciaglia Antonio , Falcetelli Francesco , Di Sante Raffaella , Liverani Alfredo , Ceruti Alessandro 
Published: November 2023

AbstractThis study aims to evaluate the advantages and criticalities of applying additive manufacturing to produce climbing holds replicating real rocky surfaces. A sample of a rocky surface has been reproduced with a budget-friendly 3D scanner exploiting structured light and made in additive manufacturing. The methodology is designed to build a high-fidelity replica of the rocky surface using only minor geometry modifications to convert a 2D triangulated surface into a 3D watertight model optimised for additive manufacturing. In addition, the research uses a novel design and uncertainty estimation approach. The proposed methodology proved capable of replicating a rocky sample with sub-millimetre accuracy, which is more realistic than conventional screw-on plastic holds currently used in climbing gyms. The advantages can be addressed in terms of customisation, manufacturing cost and time reduction that could lead to real outdoor climbing experiences in indoor environments by coupling additive manufacturing techniques and reverse engineering (RE). However, operating the scanner in a rocky environment and the considerable size of the climbing routes suggest that further research is needed to extend the proposed methodology to real case studies. Further analysis should focus on selecting the best material and additive manufacturing technology to produce structural components for climbing environments.
Male marriage squeeze and a sociodemographic portrait of involuntary bachelors in rural China
Authors: Yang Liuqing , Guo Zhen , Liang Haili , Samuel Persis , Dong Lin , Peng Yuan , Li Shuzhuo 
Published: November 2023

AbstractThis study uses, primarily, the 2020 National Population Census data to comprehensively examine the phenomenon of the “male marriage squeeze” and provide a socio-demographic portrait of involuntary bachelors in rural China. The descriptive findings make clear the pronounced male marriage squeeze in rural China. In 2020, China recorded its highest historical sex ratio of marriageable population, reaching 110. The age-specific proportions of never-married men surpass those of women, particularly in rural areas where a significant proportion of men remain unmarried throughout their lives. Between 2010 and 2020, men in rural areas exhibited a notable trend of delayed marriage. The likelihood of rural men getting married steadily declined during this decade, with rural men significantly less likely to get married than urban men. In China, the concentration of involuntary bachelors is mainly in rural areas, characterized by lower socioeconomic status, and inferior living conditions. While educational qualification among involuntary bachelors in rural areas has improved, it still lags behind that of currently or previously married men. Another problem is that the elderly population in rural areas faces resource scarcity, increasing the reliance on the minimum subsistence allowance. Elderly involuntary bachelors are generally in poorer health than their married peers, and the health disparity is widening. To make matters worse, a high percentage of these men live alone.
A review of optimization modeling and solution methods in renewable energy systems
Authors: Yu Shiwei , You Limin , Zhou Shuangshuang 
Published: November 2023

AbstractThe advancement of renewable energy (RE) represents a pivotal strategy in mitigating climate change and advancing energy transition efforts. A current of research pertains to strategies for fostering RE growth. Among the frequently proposed approaches, employing optimization models to facilitate decision-making stands out prominently. Drawing from an extensive dataset comprising 32806 literature entries encompassing the optimization of renewable energy systems (RES) from 1990 to 2023 within the Web of Science database, this study reviews the decision-making optimization problems, models, and solution methods thereof throughout the renewable energy development and utilization chain (REDUC) process. This review also endeavors to structure and assess the contextual landscape of RES optimization modeling research. As evidenced by the literature review, optimization modeling effectively resolves decision-making predicaments spanning RE investment, construction, operation and maintenance, and scheduling. Predominantly, a hybrid model that combines prediction, optimization, simulation, and assessment methodologies emerges as the favored approach for optimizing RES-related decisions. The primary framework prevalent in extant research solutions entails the dissection and linearization of established models, in combination with hybrid analytical strategies and artificial intelligence algorithms. Noteworthy advancements within modeling encompass domains such as uncertainty, multienergy carrier considerations, and the refinement of spatiotemporal resolution. In the realm of algorithmic solutions for RES optimization models, a pronounced focus is anticipated on the convergence of analytical techniques with artificial intelligence-driven optimization. Furthermore, this study serves to facilitate a comprehensive understanding of research trajectories and existing gaps, expediting the identification of pertinent optimization models conducive to enhancing the efficiency of REDUC development endeavors.
Evaluation of a Pilot: Inspection Facilitation and Collaboration Using a Mixed Reality Device
Authors: Baker Peter , Cathey Tamika , Auclair Jared R. 
Published: November 2023

AbstractThe COVID-19 pandemic forced industry and national regulatory authorities (NRAs) to think about innovative ways to ensure business continuity, including Good Manufacturing Practices (GMP) inspections. Even prior to COVID-19, it was understood that GMP site inspections, especially redundant inspections, are a time and resource-intensive process for both industry and regulators in high-income countries and often prohibitive to resource-challenged countries. Thus, we investigated the use of a mixed reality device and Microsoft (MS) Teams as a platform for mixed reality (hybrid) remote inspection. This pilot involved a mock GMP inspection of a drug manufacturing facility in the United States. The mock inspection was conducted by two former USFDA (US Food and Drug Administration) investigators, facilitated by representatives from Northeastern University along with The Bill and Melinda Gates Foundation. Also participating in the inspection were inspectors from national regulatory agencies (NRAs) from the African continent, including Nigeria, South Africa, Uganda, and Zimbabwe, and representatives from the Pre-Qualification Inspection Unit at the World Health Organization (WHO). Harmonized inspectional guidance from PIC/s (GMP Guide) and WHO (TRS 823) were used as the standards for conducting the mock inspection. We found that mixed reality, used in conjunction with a collaborative text messaging system, is a viable tool to facilitate remote inspections and allows inspectors participating remotely to write their own independent inspection reports.
IOP volunteerism: Acting as individuals, acting as a community
Authors: Adler Seymour , Bazigos Michael N. , Desrosiers Erica , Goldberg Andrea , Heaton Laura , Kamin Allen , Nelson Miriam 
Published: November 2023

AbstractTippins et al. (2023) challenge I-O psychologists to more actively – in Miller’s oft-quoted APA presidential address – “give psychology away.” Their article provides stirring examples of the impact several of our colleagues have made in giving psychology away. In thinking about how to encourage and facilitate more of us to volunteer, we’d like to share several thoughts on our roles as I-Os, both as individuals and as a community. In particular, we propose that volunteerism is an expression of our calling as I-Os; suggest five roles we can play as individuals; discuss three roles for the community at-large; and conclude with a call to action.
On the representability of actions of Leibniz algebras and Poisson algebras
Authors: Cigoli Alan S. , Mancini Manuel , Metere Giuseppe 
Published: November 2023

AbstractIn a recent paper, motivated by the study of central extensions of associative algebras, George Janelidze introduces the notion of weakly action representable category. In this paper, we show that the category of Leibniz algebras is weakly action representable and we characterize the class of acting morphisms. Moreover, we study the representability of actions of the category of Poisson algebras and we prove that the subvariety of commutative Poisson algebras is not weakly action representable.
Juan Donoso Cortés and Political Theology
Authors: Steilen Felix 
Published: November 2023

AbstractThe article offers a reconstruction of Donoso's idea of political theology by analyzing his main work, the 1851 Essay on Catholicism, Socialism, and Liberalism. Commentators have often confined the role of Donoso to a footnote in the literature on Carl Schmitt. To better appreciate his original thought, this article analyzes his account of the secularization of theological ideas. Donoso understands modern politics as a confrontation between the philosophies of socialism, liberalism, and Catholicism, which diverge on questions about the nature of man, of evil, and of society. Modern worldviews are thus read through simplified Catholic dogma. Donoso's vision of politics as secularized theology develops in dialogue with Pierre-Joseph Proudhon. The Donoso-Proudhon-Schmitt rapport allows a consideration of political theology in terms of metaphor and literary device. Within this larger story, Donoso represents the moment when a traditionalist figure of thought slowly detaches itself from its historical foundations.
A psychometric evaluation of the NIH Toolbox fluid cognition tests adapted for Swahili and Dholuo languages in Kenyan children and adolescents
Authors: McHenry Megan S. , Roose Anna , Abuonji Emily , Nyalumbe Mark , Ayuku David , Ayodo George , Tran Tuan M. , Kaat Aaron J. 
Published: November 2023

AbstractObjective:Our objective was to evaluate the psychometric properties of the culturally adapted NIH Toolbox African Languages® when used in Swahili and Dholuo-speaking children in western Kenya.Method:Swahili-speaking participants were recruited from Eldoret and Dholuo-speaking participants from Ajigo; all were <14 years of age and enrolled in primary school. Participants completed a demographics questionnaire and five fluid cognition tests of the NIH Toolbox® African Languages program, including Flanker, Dimensional Change Card Sort (DCCS), Picture Sequence Memory, Pattern Comparison, and List Sorting tests. Statistical analyses examined aspects of reliability, including internal consistency (in both languages) and test–retest reliability (in Dholuo only).Results:Participants included 479 children (n = 239, Swahili-speaking; n = 240, Dholuo-speaking). Generally, the tests had acceptable psychometric properties for research use within Swahili- and Dholuo-speaking populations (mean age = 10.5; SD = 2.3). Issues related to shape identification and accuracy over speed limited the utility of DCCS for many participants, with approximately 25% of children unable to match based on shape. These cultural differences affected outcomes of reliability testing among the Dholuo-speaking cohort, where accuracy improved across all five tests, including speed.Conclusions:There is preliminary evidence that the NIH Toolbox ® African Languages potentially offers a valid assessment of development and performance using tests of fluid cognition in Swahili and Dholuo among research settings. With piloting underway across other diverse settings, future research should gather additional evidence on the clinical utility and acceptability of these tests, specifically through the establishment of norming data among Kenyan regions and evaluating these psychometric properties.
Neuropsychiatric symptoms after moderate-to-severe traumatic brain injury in Vietnam: Assessment, prevalence, and impact on caregivers
Authors: Nguyen My-Ngan , Pham Rose , Nguyen Tuong-Vu , Lam-Nguyen Nha-Truc , McDonald Skye , Quang Halle 
Published: November 2023

AbstractObjective:Neuropsychiatric symptoms (NPSs) after moderate-to-severe traumatic brain injury (TBI) have been well documented in WEIRD (Western, educated, industrialized, rich, and democratic) populations. In non-WEIRD populations, such as Vietnam, however, patients with TBI clinically remain uninvestigated with potential neuropsychiatric disorders, limiting on-time critical interventions. This study aims to (1) adapt the Vietnamese Neuropsychiatric Inventory (V-NPI), (2) examine NPSs after moderate-to-severe TBI and (3) evaluate their impact on caregiver burden and well-being in Vietnam.Method:Caregivers of seventy-five patients with TBI completed the V-NPI, and other behavior, mood, and caregiver burden scales.Results:Our findings demonstrated good internal consistency, convergent validity, and structural validity of the V-NPI. Caregivers reported that 78.7% of patients with TBI had at least three symptoms and 16.0% had more than seven. Behavioral and mood symptoms were more prevalent (ranging from 44.00% to 82.67% and from 46.67% to 66.67%, respectively) and severe in the TBI group. Importantly, NPSs in patients with TBI uniquely predicted 55.95% and 33.98% of caregiver burden and psychological well-being, respectively.Conclusion:This study reveals the first evidence for the presence and severity of NPSs after TBI in Vietnam, highlighting an urgent need for greater awareness and clinical assessment of these symptoms in clinical practice. The adapted V-NPI can serve as a useful tool to facilitate such assessments and interventions. In addition, given the significant impact of NPS on caregiver burden and well-being, psychosocial support for caregivers should be established.