bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and validation of an individualized metabolic prognostic signature for predicting the biochemical recurrence of prostate cancer based on the immune microenvironment
Authors: Hu Bintao , Zhang Xi , Zhu Shiqing , Wang Chengwei , Deng Zhiyao , Wang Tao , Wu Yue 
Published: January 2024

Abstract
Background
Prostate cancer (PCa) is the most prevalent genitourinary malignancy in men, with a significant proportion of patients developing biochemical recurrence (BCR) after treatment. The immune microenvironment and metabolic alterations have crucial implications for the tumorigenesis and progression of PCa. Therefore, identifying metabolic genes associated with the immune microenvironment holds promise for predicting BCR and improving PCa prognosis.

Methods
In this study, ssGSEA and hierarchical clustering analysis were first conducted to evaluate and group PCa samples, followed by the use of the ESTIMATE and CIBERSORT algorithms to characterize the immunophenotypes and tumor microenvironment. The differential metabolic genes (MTGs) between groups were utilized to develop a prognostic-related signature. The predictive performance of the signature was assessed by principal component analysis (PCA), receiver operating characteristic (ROC) curve analysis, survival analysis, and the TIDE algorithm. A miRNA-MTGs regulatory network and predictive nomogram were constructed. Moreover, the expression of prognostic MTGs in PCa was detected by RT‒qPCR.

Results
PCa samples from the TCGA cohort were separated into two groups: the immune-low group and immune-high group. Forty-eight differentially expressed MTGs between the groups were identified, including 37 up-regulated and 11 down-regulated MTGs. Subsequently, CEL, CYP3A4, and PDE6G were identified as the genes most strongly associated with the BCR of PCa patients and these genes were utilized to establish the MTGs-based prognostic signatures. PCA, ROC curves analysis, Kaplan–Meier survival analysis, and the nomogram all showed the good predictive ability of the signature regardless of clinical variables. Furthermore, the MTGs-based signature was indicated as a potential predictive biomarker for immunotherapy response. Nine miRNAs involved in the regulation of prognostic MTGs were determined. In addition to the CEL gene, the PDE6G and CYP3A4 genes were expressed at higher levels in PCa samples.

Conclusions
The MTGs-based signature represents a novel approach with promising potential for predicting BCR in PCa patients.
Making Our Way Out
Authors: Fischer Anne Gray , Matthiesen Sara , LeBrón Marisol 
Published: January 2024

Abstract
The massive and multiscaled scope of state violence—religious and racist genocide, medical apartheid, colonial dispossession, global austerity, and capitalist resource extraction that accelerates our climate catastrophe—indexes the immense potential of state infrastructures. Global systems that can accumulate and wield such sprawling powers might instead be used to redistribute resources on that same scale. This issue of Radical History Review, organized around the theme “Feminists Confront State Violence,” asks about the capacity of the state to affirm life given its structural investments in violence, paying specific attention to how activists have theorized and devised strategies to win redress from extant institutions. Ultimately, contributing authors document how feminists have negotiated a fundamental contradiction: how, and why, does one make demands for the equitable distribution of care, safety, and life on a state that unequally distributes violence, immiseration, and death? Together, these essays provide an archival toolkit of Black, abolitionist, anarchist, anticolonial, and anticapitalist feminist strategies to radically remake worlds inside this one.
From “Armies of Love” to Demanding Legal Abortion
Authors: Green Rioja Romina A. 
Published: January 2024

Abstract
This article argues that Argentina’s recent feminist “green wave” emerged from the political militancy of working-class women responding to the economic violence of the 1990s neoliberal reforms and the nation’s financial collapse in 2001. The first section details the gendered experience of the 1990s neoliberal crisis from the “feminization” of the workforce, the rise in child mortality due to malnutrition, and, as a result, the increase in deaths from clandestine abortions. The second section details the development of gendered consciousness among working-class women through the formation of espacios de mujeres (women’s spaces) after 2001. The espacios allowed piqueteras (unemployed women) to organize against patriarchal violence and gendered marginalization in their homes and organizations. The third section examines how working-class women’s participation in the yearly National Women’s Encounter transformed it from a small women’s gathering to a conference that brought together social movements under a shared feminist abortion rights banner.
Taking Over, Living-In
Authors: Gill-Sadler Randi , Edwards Erica R. 
Published: January 2024

Abstract
This article places Toni Cade Bambara at the center of a history of Black feminist culture and its radical politics of repair through a close reading of Bambara’s and Louis Massiah’s film treatment Come as You Are. In its depiction of a group of poor, unhoused Philadelphians taking over a luxury apartment building for a live-in, Come as You Are posits taking over and living-in as practices of refusal of the state care offered through social workers, the housing authority, welfare agencies, and the police. Bambara’s cinematic work points to Black feminist representations of state violence and contra-state forms of repair that complicate how feminist theory encounters the problem of reparative appeal.
Organizing for the Decriminalization of Sex Work in South Africa
Authors: Thusi India 
Published: January 2024

Abstract
Sex worker organizations in South Africa have engaged in significant advocacy to eliminate the current laws that criminalize the sale of sexual services there. Advocates argue that criminalization stigmatizes sex workers by labeling their conduct as unlawful, pushing them further to the margins of society, and making it difficult for sex workers to access health and welfare services. They claim that removing the threat of imminent arrest and caging would improve the material conditions under which sex workers live. But South Africa is a nation that struggles with income inequality, and many people live in poverty. There is xenophobia. There is social inequality. There is sexism. Decriminalization of sex work would not eliminate all these systemic problems. However, it might be a necessary first step for sex workers to live in a material world where they feel safer and in better control of their lives: a world where they are free to imagine a better future for themselves without the threat of state confinement for their labor choices.
Quantitative somatosensory assessments in patients with persistent pain following groin hernia repair: A systematic review with a meta-analytical approach
Authors: Dubayev Akhmedkhan , Jensen Elisabeth Kjær , Andersen Kenneth Geving , Bjurström Martin F. , Werner Mads U. 
Published: January 2024

Objectives
Quantitative sensory testing (QST) provides an assessment of cutaneous and deep tissue sensitivity and pain perception under normal and pathological settings. Approximately 2–4% of individuals undergoing groin hernia repair (GHR) develop severe persistent postsurgical pain (PPSP). The aims of this systematic review of PPSP-patients were (1) to retrieve and methodologically characterize the available QST literature and (2) to explore the role of QST in understanding mechanisms underlying PPSP following GHR.

Methods
A systematic literature search was conducted from JAN-1992 to SEP-2022 in PubMed, EMBASE, and Google Scholar. For inclusion, studies had to report at least one QST-modality in patients with PPSP. Risk of bias assessment of the studies was conducted utilizing the Newcastle Ottawa Scale and Cochrane’s Risk of Bias assessment tool 2.0. The review provided both a qualitative and quantitative analysis of the results. A random effects model was used for meta-analysis.

Results
Twenty-five studies were included (5 randomized controlled trials, 20 non-randomized controlled trials). Overall, risk of bias was low. Compared with the contralateral side or controls, there were significant alterations in somatosensory function of the surgical site in PPSP-patients. Following thresholds were significantly increased: mechanical detection thresholds for punctate stimuli (mean difference (95% CI) 3.3 (1.6, 6.9) mN (P = 0.002)), warmth detection thresholds (3.2 (1.6, 4.7) °C (P = 0.0001)), cool detection thresholds (-3.2 (-4.9, -1.6) °C (P = 0.0001)), and heat pain thresholds (1.9 (1.1, 2.7) °C (P = 0.00001)). However, the pressure pain thresholds were significantly decreased (-76 (-123, -30) kPa (P = 0.001)).

Conclusion
Our review demonstrates a plethora of methods used regarding outcome assessments, data processing, and data interpretation. From a pathophysiological perspective, the most consistent findings were postsurgical cutaneous deafferentation and development of a pain generator in deeper connective tissues.

Trial registration
CRD42022331750.
A Rare Case of Cornelia De Lange Syndrome
Authors: Surya Rao Rao Venkata Mahipathy  , Manoj Ananthappan  , Praveen Ganesh Natarajan  , Mamta Singaram  , Alagar Raja Durairaj  
Published: January 2024

An 8-year-old female child was referred to our Cleft and Craniofacial centre, Department of Plastic & Reconstructive Surgery, Saveetha Medical College & Hospital, after being diagnosed with cleft palate and hyper nasal speech. She is the first child born from a non- consanguineous marriage with a birth weight of 2.6 kg. Following her, a girl and a boy were born and exhibited no apparent abnormalities. Both parents maintain a normal status, and there is no history of deformities in their family lineage. The patient underwent a typical vaginal delivery and was born at full term. At the time of birth, the child was differentially diagnosed with a neurogenic tumour in the occipital region of the skull. The child was not treated for the growth in the occiput. Patient had growth retardation, global developmental delays and features of facial dysmorphism like microcephaly, bushy and uni eyebrow, long eyelashes, low set ears, small nose, concave nasal bridge, and hirsutism. The child was subjected to an MRI brain scan in our unit and it suggested a hyperechoic lesion in the midline at C3, C4 level with an impression of Arnold Chiari malformation. Clinically, on palpation of the lesion, it approximately measured 4x3 cm, soft in consistency and the lesion hardened while coughing or sneezing and regressed back to normalcy within a few minutes. USG abdomen was done and a well-defined hypoechoic dumbbell shaped bilobed solid lesion with smooth margins with no significant vascularity was noted in the gastrohepatic region. Echocardiogram was done and it ruled out cardiac anomalies like patent ductus arteriosus or coarctation of aorta. Inspection of the oral cavity was done to diagnose the cleft of the secondary palate. (Fig. 1) Based on all features in examination and investigation, a diagnosis of Cornelia de Lange syndrome was made. The surgery was planned after a routine blood workup. The child was advised for CECT of abdomen to confirm the USG findings of abdominal anomalies, however, the report suggested cystic lymphangioma. (Fig. 2) Fitness for palatoplasty surgery was obtained from paediatrician, paediatric surgeon, neurosurgeon, cardiologist and anaesthesiologist. Under antibiotic cover, the child was operated under general anaesthesia for palatoplasty by Sommerlad’s technique. (Fig. 3 & 4) The post-operative period was uneventful.
Profinite genus of fundamental groups of compact flat manifolds with the cyclic holonomy group of square-free order
Authors: Nery Genildo de Jesus 
Published: January 2024

Abstract
In this article, we study the extent to which an n-dimensional compact flat manifold with the cyclic holonomy group of square-free order may be distinguished by the finite quotients of its fundamental group. In particular, we display a formula for the cardinality of profinite genus of the fundamental group of an n-dimensional compact flat manifold with the cyclic holonomy group of square-free order.
Educación y Habilidades desde el Contexto de la Educación Infantil
Authors: Portilla Benavides Milton Mauricio 
Published: January 2024

El avance vertiginoso de la sociedad, lleva a repensar la importancia del desarrollo de habilidades en el contexto educativo; de esta manera, el presente artículo se centra en proponer las habilidades iniciales que los niños deben desarrollar desde la perspectiva de la formación y se presentan de forma cotidiana en la educación infantil, proponiéndolas como habilidades-competencias que son necesarias en la labor docente. De igual manera, es importante manifestar que no se desconoce la propuesta del Ministerio de Educación Nacional de Colombia [MEN], ya que aquí se exponen y se explicitan sus aportes.
Es importante manifestar que se hace un recorrido por las diferentes habilidades que se deben desarrollar en especial en la escuela, sin desconocer los contextos familiar y social; de allí que el pre-texto de este escrito, no tenga otra intención que mostrar si la escuela está respondiendo a esta dinámica, que permite desarrollos cognitivos y socioculturales, que son necesarios para comprender el mundo y sus relaciones, desde la educación infantil.
Pregnant Women's Knowledge Regarding Healthy Nutrition During Pregnancy at Shahid Hama Rash Primary Health Center, Sulaimaniyah, Iraq
Authors: Qadir Shwan , Saeed Mahabat , Kakabra Cheeman , Ahmad Livyar 
Published: January 2024

Background: In the antenatal period, the nutritional demand of women upsurges to compensate for physiological and psychological changes and nutritional computations by the growing fetus for energy, macro, and micronutrients. Nutrition knowledge is essential in conscious of ample nutrition intake among pregnant women.

Objective: This study aimed to assess pregnant women’s knowledge of healthy nutrition.

Materials and Methods: The non-probability convenient method was used as the sampling technique in this descriptive study. The process of data collection was continued from 26th July 2022 to 26th September 2022. A hundred women were selected from Shahid Hama Rash Primary Health Center, Sulaimaniyah, Iraq. A well-designed questionnaire was constructed, in which its first part includes sociodemographic characteristics and the second part includes questions regarding participants' knowledge.

Results: We showed that 82% of participants had good knowledge, as well as 18% of them, had fair knowledge regarding healthy nutrition. At the same time, none of the pregnant women had poor knowledge.

Conclusions: We concluded that most study participants had good knowledge, and no significant association was found between knowledge of pregnant mothers and their sociodemographic variables.
Assessment of Postoperative Nurse’s Intervention in Patients with Laparoscopic Cholecystectomy at Teaching Hospitals in Sulaimaniyah, Iraq
Authors: Hassan Heshu , Saeed Kamal 
Published: January 2024

Background: Laparoscopic cholecystectomy is the standard gold treatment for gallstones. However, its postoperative complications can be overcome through high-quality knowledge and practice of health care providers, especially nurses working at surgical wards that play major roles in post-operated patient management.

Objective: This descriptive cross-sectional study aimed to assess the postoperative nurses' intervention for patients with laparoscopic cholecystectomy and to determine the relationship between nurses' interventions and their sociodemographic characteristics.

Patients and Methods: A total of 65 experienced nurses at surgical wards in Sulaimaniyah Teaching Hospitals were included from March to August 2022 to determine nurses' intervention domains in laparoscopic cholecystectomy. For this purpose, a well-designed questionnaire was used to collect the participant's data, including sociodemographic data and clinical data.

Results: Most participating nurses (38.5%) were aged 30-39 years, females (66.2%), from the urban region (87.7%), married (66.2%), completed nursing institute (76.9%), and full-time hospital staff (66.2%). Also, most (36.9%) had 1-5 years of work experience and did not take part in training courses (50.8%). In comparison, 41.5% of them participated in the training courses for <6 months. Furthermore, most of the studied variables for the postoperative nurses’ intervention items were significantly/highly significantly associated between the first and second assessments. Moreover, a significant difference between gender, education, and residency in the overall assessment of postoperative nurses’ intervention in the first assessment and a significant association only for residency was reported for the second assessment.

Conclusions: Nurses who worked at surgical wards were professional in relieving pain, improving respiratory status, maintaining skin integrity/drainage, improving nutritional status, and monitoring/managing potential complications for patients who underwent laparoscopic cholecystectomy, regardless of their sociodemographic variables.
Self-care and Quality of Life in Patients with Chronic Renal Failure Undergoing Hemodialysis at Sulaimaniyah Province, Kurdistan Region of Iraq
Authors: Ibrahim Khalil , Ismael Niyan 
Published: January 2024

Background: Chronic renal failure (CRF) is a significant and growing public health issue globally with a negative impact on self-care and quality of life (QoL). Self-care and QoL are essential aspects of controlling the adverse effects of the illness.

Objectives: To assess self-care and QoL of patients with CRF who undergo hemodialysis (HD).

Patients and Methods: A descriptive-analytical design was carried out in Sulaimani Province Hemodialysis Centers/Unit from March to September 2022. About 150 patients with CRF undergoing hemodialysis consented to participate in the study. Non-probability convince sample technique was used to select the participants. The data were collected through a questionnaire by direct interview.

Results: Most patients were ≥60 years, males, married, illiterate, lived in an urban area and had barely sufficient economic status with 4-6 family members. The study's findings revealed inadequate self-care in >50% of patients. A significant correlation between self-care and QoL in limitation of activities was found for CRF patients who underwent Hemodialysis with no correlation for general health, physical and emotional, and energy and emotion. Also, there was a significant difference between QoL and age (for the general health domain), gender, and level of education (for the limitations of the activities domain). Mean self-care measurement was significantly associated between previous occupation and duration of Hemodialysis.

Conclusions: Most patients had inadequate self-care and poor QoL, which means that higher self-care performance was associated with better QoL in the limitation of activities only and no other QoL domains.
Assessment of dimensions of mandibular condyles and their correlation with jaw movements in rheumatoid arthritis patients
Authors: Jalal Ranj , Ahmed Khadija , Saeed Shahla 
Published: January 2024

Objectives: The aim of this study is to assess the condylar dimensions in Rheumatoid Arthritis (RA) patients and compare them to condylar dimensions of healthy persons and try to find out correlations between dimensional condylar changes and jaw movements in RA patients.

Methods: This case-control study was performed on 40 RA patients with ten healthy adults (control cases). Clinical examination with Cone Beam Computerized Tomography (CBCT) was done for participants. Independent and paired t-tests with correlation coefficient tests were used for data analysis by the SPSS program.

Results: There was a significant difference between RA and controls regarding the means of their unassisted and assisted maximum mouth opening and the mean of right lateral jaw excursion also. The mean condylar length in RA patients was 6.88 mm while in control cases was 7.61, and the mean condylar width in RA was 16.77 and in controls was 16.53 mm, and the mean condylar height was 18.02 mm in RA and 21.14 mm in controls without significant difference between both groups. There was a positive correlation between the condylar dimensions and the jaw movements.

Conclusions: Condylar height and width were decreased in RA patients in comparison to the control group, indicating bony changes in the upper condylar surface. In addition, RA patients have decreased range of jaw movements like mouth opening, which might result from bony changes and reduction in condylar dimensions.
Food taboo and food preference among the rural and urban lactating mothers of Paschim Medinipur district of West Bengal
Authors: Mitra Shreyosi 
Published: January 2024

Background: Food taboo is a prohibition against consuming certain foods and food preference refers to the way in which people choose from among available comestibles on the basis of biological or economic perceptions including taste, value, purity, ease or difficulty of preparation, and the availability of fuel and other preparation tools. This cultural practice can be studied from different theoretical perspectives.
Methods: For the present study total number of 948 [Hindu rural caste (347), Hindu urban caste (356), Lodha (245) rural areas] lactating mothers were chosen for collecting data regarding their socio-demographic features and the cultural practices (food taboo and food preferences during the period of lactation) followed by them. Both interview and case study method was applied for collecting data. SPSS 16.0 was used to entry and analyse the data.
Results: Reveals that hindu caste rural participants showed significantly higher preference for certain food items compared to their urban counterpart and the Lodha participants. Significantly, more number of HCR participants showed preference towards certain food items during lactation to improve the quality of breast milk. Result also shows that there were significant differences across hindu caste rural than their urban counterpart and the Lodha participants with respect to all the variables related to food taboo.
Conclusions: Cultural practices have influenced the health behaviour like breastfeeding practices of the lactating mothers.