bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer
Authors: Tan Yan Qin , Chiou Yi-Shiou , Guo Hui , Zhang Shuwei , Huang Xiaoming , Dukanya Dukanya , Kumar Arun M. , Basappa Shreeja , Liu Suling , Zhu Tao , Basappa Basappa , Pandey Vijay , Lobie Peter E. 
Published: January 2024

AbstractAberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC. Herein, the phosphorylated to non-phosphorylated ratio of BAD, an effector of PI3K/AKT promoting cell survival, was observed to be correlated with worse clinicopathologic indicators of outcome, including higher grade, higher proliferative index and lymph node metastasis. The structural optimization of a previously reported inhibitor of BAD-Ser99 phosphorylation was therefore achieved to generate a small molecule inhibiting the phosphorylation of BAD at Ser99 with enhanced potency and improved oral bioavailability. The molecule 2-((4-(2,3-dichlorophenyl)piperazin-1-yl)(pyridin-3-yl)methyl) phenol (NCK) displayed no toxicity at supra-therapeutic doses and was therefore assessed for utility in TNBC. NCK promoted apoptosis and G0/G1 cell cycle arrest of TNBC cell lines in vitro, concordant with gene expression analyses, and reduced in vivo xenograft growth and metastatic burden, demonstrating efficacy as a single agent. Additionally, combinatorial oncology compound library screening demonstrated that NCK synergized with tyrosine kinase inhibitors (TKIs), specifically OSI-930 or Crizotinib in reducing cell viability and promoting apoptosis of TNBC cells. The synergistic effects of NCK and TKIs were also observed in vivo with complete regression of a percentage of TNBC cell line derived xenografts and prevention of metastatic spread. In patient-derived TNBC xenograft models, NCK prolonged survival times of host animals, and in combination with TKIs generated superior survival outcomes to single agent treatment. Hence, this study provides proof of concept to further develop rational and mechanistic based therapeutic strategies to ameliorate the outcome of TNBC.
Treating Pediatric Feeding Disorders and Dysphagia: Evidence-Based Interventions for School-Based Clinicians
Authors: West Kristen M. 
Published: January 2024

Purpose:
Children with pediatric feeding disorder (PFD) and dysphagia are increasingly prevalent in school-based caseloads. This tutorial discusses the current best practices for treating children with PFD and dysphagia as well as considerations for service delivery in educational settings.

Method:
The rationale for treating PFD and dysphagia in an educational setting is discussed. A review of various interventions for PFD and dysphagia and a discussion of the available evidence are provided. The principles of experience-dependent neuroplasticity and theory-driven practice are discussed in light of the need for additional empirical research. Practical considerations to enhance evidence-based practice for PFD and dysphagia in educational settings are explored.

Results:
The reader will be able to identify evidence-based interventions for students with PFD and dysphagia and plan for the implementation of these approaches in the school setting.

Conclusions:
Students with PFD and dysphagia require skilled interventions to support their participation in educationally relevant activities and to promote continued development of feeding and swallowing skills while at school. A discussion of the current evidence for various interventions is provided to promote the utilization of evidence-based interventions in school-based settings.
Die Transanale Endoskopische Mikrochirurgie (TEM) ist eine chirurgische Option zur Erhaltung der Stuhlkontinenz bei ausgewählten tiefsitzenden Rektumkarzinomen
Authors: Schaffitzel Katrin Marlene , zu Putlitz Stephanie , Gölder Stefan Karl , Kurek Ralf , Siech Marco 
Published: January 2024

Zusammenfassung
Einleitung Trotz der Erfindung vor über 40 Jahren hat sich die TEM nicht flächendeckend durchgesetzt. Gründe sind vor allem hohe Anschaffungskosten, die anspruchsvolle Technik und alternative Therapiemöglichkeiten (radikale Resektionsverfahren), die eine größere onkologische Sicherheit bieten. Allerdings kann die Vermeidung großer Bauchoperation mit Stomaanlage und häufigeren Komplikationen das höhere Rezidivrisiko für einige Patienten aufwiegen.Wir untersuchten die Resultate der modifizierten und in der Anschaffung kostengünstigeren V-TEM bei der Resektion von Adenomen und Karzinomen und diskutieren den heutigen Stellenwert des Verfahrens anhand der Literatur.
Methode Zwischen 2003 und 2019 wurden 154 Patienten an 170 Befunden mittels V-TEM operiert. Die Daten zu Operation und Follow-up wurden retrospektiv erhoben und ausgewertet.
Ergebnisse Das mediane Alter betrug 67 Jahre, 89 Patienten waren männlich und 65 weiblich. Die V-TEM wurde bei 79 Karzinomen, 77 Adenomen und 14 sonstigen Befunden eingesetzt. Die Komplikationsrate betrug 21,1%, eine R0-Resektion gelang in 78,8% der Fälle. Die Adenomrezidivrate betrug 7,3%, die Gesamtrezidivrate bei Karzinomen 11,9%, Lokalrezidive traten bei 6,8% auf. Das krankheitsspezifische Überleben betrug 100% nach 5 und 94,2% nach 10 Jahren.
Diskussion Der erfolgreiche Einsatz der TEM bei Adenomen und Frühkarzinomen ist unumstritten. Bei Karzinomen ab einem T1 high risk-Stadium muss jedoch mit Rezidivraten von über 10% gerechnet werden, wohingegen mit radikalen Verfahren bessere Ergebnisse erzielt werden können, weshalb diese als Therapie der Wahl in diesen Fällen gelten. Es gibt jedoch kaum Unterschiede bezüglich der Überlebensraten, zudem bietet die TEM eine bessere postoperative Lebensqualität. Insbesondere auch die Kombination neoadjuvanter Verfahren mit der TEM konnten in der Vergangenheit vielversprechende Ergebnisse bei fortgeschritteneren Stadien liefern. Weitere Studien und die geringeren Anschaffungskosten durch Modifikation zur V-TEM könnten der Methode in Zukunft größere Popularität verleihen.
Special Characteristics of Alpha Generation Children Behavior in Dentistry: A Literature Review
Authors: Hutajulu Jose Mario , Agustiani Hendriati , Setiawan Arlette Suzy 
Published: January 2024

AbstractTechnological developments and advances have influenced the emergence of a new generation, known as Generation Alpha. This generation comprises those born between 2010 and 2025. Born into a digital-savvy era, this generation has different characteristics from previous generations. This study aims to identify their special characteristics so that an approach can be taken, especially in managing children of the alpha generation in dentistry. A systematic search for articles, published between 2013 and 2023 analyzing the characteristics and behavior of the alpha generation and management behavior found in dentistry was conducted through PubMed, Google Scholar, SCOPUS, and EBSCO. The final analysis was carried out on 47 articles consisting of 10 articles discussing the characteristics of the alpha generation in general and 37 articles discussing the management of their behavior in dentistry. All the published articles found that an alpha child's characteristics are closely related to behavior management in dentistry. The ease with which alpha children adapt to technology is one of the strategies for managing the behavior of alpha children. However, apart from this, the alpha children tend to be unappreciative of the process, which can affect dental behavior management. Specific characteristics of the alpha generation, such as increased exposure to technology, digital media consumption habits, and lack of respect for the process, have important implications for communication and adaptation to patient behavior management in dentistry. Understanding these characteristics is crucial for designing an effective communication strategy and adjusting appropriate behavior management to maintain the quality of dental care for this generation in the dentistry environment.
Effect of Surface Treatment and Resin Cement on the Bond Strength of an Advanced Lithium Disilicate
Authors: Lu Yuqing , Bierman Thera Elisa , Dal Piva Amanda Maria de Oliveira , Tribst João Paulo Mendes , Feilzer Albert J. , Kleverlaan Cornelis J. 
Published: January 2024

Abstract
Objectives The aim of the study was to evaluate the effect of surface treatment and resin cement on the bond strength of conventional and advanced lithium disilicates (ALDs).
Materials and Methods Ceramic slices (2 × 13 × 15 mm) of conventional lithium disilicate (LD) (IPS e.max CAD) and ALD (CEREC Tessera) were sectioned, polished, and divided into 16 groups (n = 10) according to the factors: ceramic, surface treatment, and resin cement (Panavia V5 and Variolink Esthetic DC). Surface treatments consisted of hydrofluoric acid 4.9% etching for 20 seconds (Hf20) or 30 seconds (Hf30), self-etching ceramic primer (Se), and sandblasting (Sb). Then, a resin cement cylinder (Ø = 2.5 mm) was manufactured on each specimen's surface. The specimens were then submitted to a shear bond strength (SBS) test. Surface roughness was evaluated through a contact profilometer, and surface morphology was evaluated under scanning electron microscopy for qualitative analysis.
Statistical Analysis Two-way analysis of variance (ANOVA) was used to analyze the data of SBS and surface roughness. For bond strength, the effects of surface treatment, resin cement, and the interaction were analyzed for each ceramic. For roughness, analyzed factors include ceramic and surface treatment.
Results ANOVA revealed that ceramic (p = 0.047) and surface treatment (p < 0.001) factors affected the bond strength, while the cements performed similarly. Both materials showed adequate bond strength (ALD 19.1 ± 7.7 MPa; LD 17.1 ± 7.9 MPa). Sb protocol showed the lowest mean value (9.6 ± 2.9 MPa) compared with Hf20 (22.0 ± 7.1 MPa), Hf30 (21.7 ± 7.4 MPa), and Se (19.3 ± 6.0 MPa).
Conclusion For both ceramics, the highest performance was obtained after applying Se and Hf20 or Hf30. Therefore, longer etching time is unnecessary. Sb protocol must be avoided.
Antifungal Resistance in Pulmonary Aspergillosis
Authors: Verweij Paul E. , Song Yinggai , Buil Jochem B. , Zhang Jianhua , Melchers Willem J.G. 
Published: January 2024

AbstractAspergilli may cause various pulmonary diseases in humans, including allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), and acute invasive pulmonary aspergillosis (IPA). In addition, chronic colonization may occur in cystic fibrosis (CF). Aspergillus fumigatus represents the main pathogen, which may employ different morphotypes, for example, conidia, hyphal growth, and asexual sporulation, in the various Aspergillus diseases. These morphotypes determine the ease by which A. fumigatus can adapt to stress by antifungal drug exposure, usually resulting in one or more resistance mutations. Key factors that enable the emergence of resistance include genetic variation and selection. The ability to create genetic variation depends on the reproduction mode, including, sexual, parasexual, and asexual, and the population size. These reproduction cycles may take place in the host and/or in the environment, usually when specific conditions are present. Environmental resistance is commonly characterized by tandem repeat (TR)-mediated mutations, while in-host resistance selection results in single-resistance mutations. Reported cases from the literature indicate that environmental resistance mutations are almost exclusively present in patients with IA indicating that the risk for in-host resistance selection is very low. In aspergilloma, single-point mutations are the dominant resistance genotype, while in other chronic Aspergillus diseases, for example, ABPA, CPA, and CF, both TR-mediated and single-resistance mutations are reported. Insights into the pathogenesis of resistance selection in various Aspergillus diseases may help to improve diagnostic and therapeutic strategies.
Microbiology of Severe Community-Acquired Pneumonia and the Role of Rapid Molecular Techniques
Authors: Pickens Chiagozie I. , Gao Catherine A. , Morales-Nebreda Luisa , Wunderink Richard G. 
Published: January 2024

AbstractThe microbiology of severe community acquired pneumonia (SCAP) has implications on management, clinical outcomes and public health policy. Therefore, knowledge of the etiologies of SCAP and methods to identify these microorganisms is key. Bacteria including Streptococcus pneumoniae, Staphylococcus aureus and Enterobacteriaceae continue to be important causes of SCAP. Viruses remain the most commonly identified etiology of SCAP. Atypical organisms are also important etiologies of SCAP and are critical to identify for public health. With the increased number of immunocompromised individuals, less common pathogens may also be found as the causative agent of SCAP. Traditional diagnostic tests, including semi-quantitative respiratory cultures, blood cultures and urinary antigens continue to hold an important role in the evaluation of patients with SCAP. Many of the limitations of the aforementioned tests are addressed by rapid, molecular diagnostic tests. Molecular diagnostics utilize culture-independent technology to identify species-specific genetic sequences. These tests are often semi-automated and provide results within hours, which provides an opportunity for expedient antibiotic stewardship. The existing literature suggests molecular diagnostic techniques may improve antibiotic stewardship in CAP, and future research should investigate optimal methods for implementation of these assays into clinical practice.
Expecting the Unexpected: Schistosomial Appendicitis in Nonendemic Area
Authors: Aravessery Abdul Rasak , Raza Maroof , Azfar Mohammad 
Published: January 2024

Abstract
Background Schistosomiasis is a granulomatous disease prevalent in tropical and subtropical areas. Appendicitis secondary to schistosomiasis is a rarely encountered presentation, even in endemic areas. Most acute intestinal schistosomiasis presents with abdominal pain and bloody diarrhea. Other atypical clinical presentations include intestinal obstruction, peritonitis, and acute appendicitis.
Case Description We report a case of a 37-year-old male from the Philippines who presented with the clinical picture of acute appendicitis and was treated with laparoscopic appendectomy. Pathological study revealed calcified Schistosomia japonicum's egg in a background of acute inflammation.
Conclusion Worldwide increase in immigration and tourism resulted in an increased number of schistosomiasis in nonendemic areas. Considering this, we are faced with the uncommon etiology of acute appendicitis.
Community-Based Ecotourism and Conservation in Tboli, Philippines
Authors: Alampay Ramon Benedicto A. 
Published: January 2024

Summary
This case study narrates the story of Lake Holon and the choices made by the Municipality of Tboli (and the indigenous people whose name it bears) in opening their sacred lake to tourism. Until 2013, tourism to the lake had been limited to occasional expeditions and outreach activities by local mountaineering groups. The municipal government chose to adopt a community-based tourism strategy as a means of empowering the resident Tboli – especially those in the villages leading to, and around, Lake Holon. From 2014 to 2018, the municipality worked with five rural villages to develop ecotourism attraction sites, while also preparing the residents to operate and manage the attractions themselves.
This narration of the Tboli experience comes primarily from direct interviews and published quotes from two persons directly involved in establishing the tourism program: Rodel Hilado, the municipal tourism officer of Tboli since 2013, and Nelly Nita Dillera, regional director for the Department of Tourism (DOT) from 2013 to 2019. Both have graciously granted permission for their names and statements to be cited in this case study. Additional details on the program and the subsequent outcomes come from local government documents and other secondary sources.

Information
© The Author 2024
Experiment investigation of CO2 regeneration properties for JLOX500 and 13X in various ways
Authors: Sun Yongbiao , Tang Jianfeng , Sun Yunbing , Wen Xiaojin , Su Hexin 
Published: January 2024

Abstract
This work presented a comparative study of CO2 regeneration for two kinds of X zeolites (JLOX500 and 13X) in different ways, such as vacuum, CH4 purge and heating regeneration. The materials characteristics of samples were determined by EDS and BET. The adsorption capacities of CO2 for original and regenerated samples were identified as the single-point adsorption dosing CO2 at 800 kPa. The results showed that JLOX500 had larger original adsorption capacity (OAC) of CO2 (4.83 mmol/g) than that of 13X (4.10 mmol/g). In vacuum regeneration, the regenerated adsorption capacities (RAC) of CO2 for both samples were almost same at all vacuum pressures (1 ~ 100 kPa); in CH4 purge regeneration, the regeneration degree (RD) for both samples were identical to each other with the flowrates (50 ~ 300 mL/min); in heating regeneration, JLOX500 had larger RACs than 13X at temperatures (50 ~ 300 °C), but had less RDs. The RACs and RDs for JLOX500 and 13X both increased as the regeneration time was prolonged. 13X would be more efficient adsorbent in the vacuum regeneration, whereas JLOX500 performed better in purge and heating regeneration.
CFD simulation of flyash fluidized-bed pulverization with superheated steam
Authors: Zhang Hongyang , Hong Yun , Liu Lin , Hu Bin , Li Jun 
Published: January 2024

Abstract
The supersonic pulverization technology uses superheated steam generated by the boiler to generate supersonic airflow through the Laval nozzle, and accelerates the flyash fed into the crushing chamber by the screw feeder, and then the flyash can be crushed in mutual collision and friction process. The present paper conducted CFD simulation of fluidized-bed pulverization with superheated steam, and both the velocity filed and the particle tracks are obtained. Convergence test was performed firstly to verify the numerical results, and three different meshes and several different numbers of particles are employed here to show the average velocity of the particles through a certain horizontal plane. The effect of some key parameters, such as distance between the two opposite nozzles and feeding locations of the flyash to the velocity filed and the particle velocity are also numerically investigated. Results show that, the best distance between the two opposite nozzles of the four-nozzle case is 142 mm and the average particle velocity distribution varies little with the flyash feeding position for the present jet mill model.
Strategies for maintaining indoor temperature in rural residences in highland pastoral areas
Authors: Sun Chang , Ju Xiaolei , Hao Wengang , Li Chunying , Zhang Jingyuan , Dong Xu 
Published: January 2024

Abstract
Previous studies on improving indoor thermal environments focus on plain areas. However, the scattered rural residences in highland pastoral areas have special climatic conditions and living habits. This article presents an approach to utilize the abundant renewable energy in the local area to create an indoor thermal environment that residents need. A rural village in Qinghai province of China was taken as the target; we used field investigation and questionnaire survey to explore typical layout. Combined with local building codes, two envelope and two heating systems were proposed to achieve indoor thermal comfort. We also introduce building simulation models and field tests to discover four combinations’ energy-saving effects in maintaining indoor thermal comfort. The average energy-saving rate in the heating season of the four schemes is 89.31%, and the mean temperature is 16.64 °C. The results suggest the heating system has a more significant influence on energy consumption than the enclosure structure, which needs attention under the same budget situation. The solar air heating system has better indoor temperature maintenance effects than the carbon fiber floor heating system. Regarding construction, the prefabricated integrated enclosure structures improve thermal insulation performance significantly.
Analysis of students’ scientific reasoning ability on static fluid topics
Authors: Fernando T J , Parno  , Diantoro M 
Published: January 2024

Abstract
The aim of the research was to identify the Scientific Reasoning abilities of high school students on the topic of Static Fluids. This type of research is a quantitative survey design. This survey research involved 78 class XII students at a private high school in East Java, Indonesia who had taken the material. This research uses a Scientific Reasoning Test instrument in the form of an essay with 7 questions at the HOTS level with Cronbach’s Alpha reliability of 0.77. The data was analyzed using descriptive statistics followed by classification based on the Static Fluid subtopic and level of Scientific Reasoning ability. The survey results show that the average score of students is 20.15 with a concrete operational level. The results of other studies indicate that the subtopics all at the concrete operational level. Meanwhile, if we look at the scientific reasoning indicators, it is found that the proportional reasoning indicators are the most problematic, with an average of 18.43 level 1. Scientific reasoning abilities are related to the mastery of concepts and learning experienced by students, therefore it is necessary to use learning that can explore these abilities such as Science, Technology, Engineering, Art and Mathematics (STEAM).
Exploration of students’ scientific literacy in work and energy through STEM-based 7E learning cycle with formative assessment
Authors: Parno  , Putri M K , Munfaridah N , Khusaini  , Fitri N , Ali M 
Published: January 2024

Abstract
21st century education requires students to have scientific literacy competencies to overcome problems in society in the globalization era. The low scientific literacy is closely related to students’ difficulties in work and energy topic. Solution is needed to improve scientific literacy by designing appropriate learning model. This study has a purpose to analyze students’ scientific literacy on work and energy through STEM-based 7E learning cycle with formative assessment. This study used embedded experimental mixed method design. The subjects were 27 of tenth grade students of Laboratory UM high school, Indonesia. Data were collected using essays of scientific literacy test with 0.657 reliability and interviews. Data were analyzed quantitatively using paired sample t-test, N-gain, and d-effect size. While the qualitative using data collection procedures, data reduction, coding, presentation, and building a conclusion. The results indicated STEM-based 7E learning cycle with formative assessment was able to increase significantly students’ scientific literacy in medium category. The results showed that majority of students at Conceptual Level which students are able to answer related with the main concept of kinetic and potential energy but but did not go beyond the concepts of scientific discipline. However, students have difficulties on indicator of creating and evaluating the experiments. For future studies, 9E Learning Cycle or aspects of ‘Art’ could be added in STEM to gain even higher students’ scientific literacy.