bluuebunny/crossref_metadata_2025_split huggingface dataset:
OCOSO2: study protocol for a single-blinded, multicentre, randomised controlled trial assessing a central venous oxygen saturation-based goal-directed therapy to reduce postoperative complications in high-risk patients after elective major surgery
Authors: Pastene Bruno , Bernat Matthieu , Baumstark Karine , Bezulier Karine , Gricourt Yann , De Guibert Jean-Manuel , Charvet Aude , Colin Manon , Leone Marc , Zieleskiewicz Laurent 
Published: October 2023

Abstract
Background
Fluid loading-based goal-directed therapy is a cornerstone of anaesthesia management in major surgery. Its widespread application has contributed to a significant improvement in perioperative morbidity and mortality. In theory, only hypovolemic patients should receive fluid therapy. However, to achieve such a diagnosis, a surrogate marker of cardiac output adequacy must be used. Current methods of fluid loading-based goal-directed therapy do not assess cardiac output adequacy. Nowadays, new devices make it possible to continuously monitor central venous oxygen saturation (ScvO2) and therefore, to assess the adequacy of perioperative cardiac output during surgery. In major surgery, ScvO2-based goal-directed therapy can be used to enhance fluid therapy and improve patient outcomes.

Methods
We designed a prospective, randomised, single-blinded, multicentre controlled superiority study with a 1:1 allocation ratio. Patients to be included will be high-risk major surgery patients (> 50 years old, ASA score > 2, major intra-abdominal or intra-thoracic surgery > 90 min). Patients in the control group will undergo standard fluid loading-based goal-directed therapy, as recommended by the guidelines. Patients in the intervention group will have ScvO2-based goal-directed therapy and receive fluid loading only if fluid responsiveness and cardiac output inadequacy are present. The primary outcome will be the Comprehensive Complication Index on day five postoperatively.

Discussion
This study is the first to address the issue of cardiac output adequacy in goal-directed therapy. Our hypothesis is that cardiac output optimisation during major surgery achieved by continuous monitoring of the ScvO2 to guide fluid therapy will result in a reduction of postoperative complications as compared with current goal-directed fluid therapy practices.

Trial registration
ClinicalTrials.gov. NCT03828565. Registered on February 4, 2019.
FlowDIR: a MATLAB tool for rapidly and probabilistically forecasting the travel directions of volcanic flows
Authors: Tennant Eleanor , Jenkins Susanna F. , Biass Sébastien 
Published: October 2023

AbstractWe present FlowDIR, a MATLAB tool that rapidly and objectively quantifies future travel direction probabilities for topographically controlled hazardous flows, based on analysis of summit topography. FlowDIR can achieve probabilistic forecasts of future travel directions in minutes and provides a basis for choosing the starting co-ordinates required by empirical flow models. In this work we describe the development of FlowDIR, perform a sensitivity analysis to determine the influence of input parameters on forecasted probabilities, and demonstrate its effectiveness in the retrospective forecasting of travel directions for block-and-ash flows and lava flows at three volcanoes with different summit morphologies (Shinmoedake, Colima and Merapi). In all case studies, the higher probability flow directions identified using FlowDIR agreed with the travel direction of historically observed flows. Given its intuitive outputs and rapid execution time, FlowDIR can be used to supplement existing modelling strategies for hazard assessment of topographically controlled hazardous flows prior to and during crisis. We demonstrate this by coupling FlowDIR output probabilities with an empirical hazard model to estimate probability of block-and-ash flow inundation at Gede volcano, Indonesia.
Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
Authors: Thiruvengadam Ramachandran , Rizvi Zaigham Abbas , Raghavan Sreevatsan , Murugesan Deepika Rathna , Gosain Mudita , Dandotiya Jyotsna , Ayushi  , Samal Sweety , Pandey Anil K. , Wadhwa Nitya , Bhatnagar Shinjini , Awasthi Amit , Garg Pramod Kumar 
Published: October 2023

Abstract
Objectives
To study clinical disease outcomes in both human and animal models to understand the pathogenicity of omicron compared to the delta variant.

Methods
In this cross-sectional observational study, clinical outcomes of adults who tested positive at 2 testing centres in Delhi National Capital Region between January 2022 and March 2022 (omicron-infected; N = 2998) were compared to a similar geographical cohort (delta-infected; N = 3292). In addition, disease course and outcomes were studied in SARS-CoV-2-infected golden Syrian hamsters and K-18 humanized ACE2 transgenic mice.

Results
Omicron variant infection was associated with a milder clinical course [83% (95% CI 61, 94) reduced risk of severity compared against delta] adjusting for vaccination, age, sex, prior infection and occupational risk. This correlated with lower disease index and vir comparing omicron with other variants in animal models.

Conclusions
Infections caused by the omicron variant were milder compared to those caused by the delta variant independent of previous immunity.
Chromosomal organization of multigene families and meiotic analysis in species of Loricariidae (Siluriformes) from Brazilian Amazon, with description of a new cytotype for genus Spatuloricaria
Authors: Almeida Bruno Rafael Ribeiro de , Farias Souza Luciano , Alves Thyana Ayres , Cardoso Adauto Lima , de Oliveira Juliana Amorim , Augusto Ribas Talita Fernanda , Dos Santos Carlos Eduardo Vasconcelos , do Nascimento Luís Adriano Santos , Sousa Leandro Melo , da Cunha Sampaio Maria Iracilda , Martins Cesar , Nagamachi Cleusa Yoshiko , Pieczarka Julio Cesar , Noronha Renata Coelho Rodrigues 
Published: October 2023

ABSTRACT
In the Amazon, some species of Loricariidae are at risk of extinction due to habitat loss and overexploitation by the ornamental fish market. Cytogenetic data related to the karyotype and meiotic cycle can contribute to understanding the reproductive biology and help management and conservation programs of these fish. Additionally, chromosomal mapping of repetitive DNA in Loricariidae may aid comparative genomic studies in this family. However, cytogenetics analysis is limited in Amazonian locariids. In this study, chromosomal mapping of multigenic families was performed in Scobinancistrus aureatus, Scobinancistrus pariolispos and Spatuloricaria sp. Meiotic analyzes were performed in Hypancistrus zebra and Hypancistrus sp. “pão”. Results showed new karyotype for Spatuloricaria sp. (2n=66, NF=82, 50m-10sm-6m). Distinct patterns of chromosomal organization of histone H1, histone H3 and snDNA U2 genes were registered in the karyotypes of the studied species, proving to be an excellent cytotaxonomic tool. Hypotheses to explain the evolutionary dynamics of these sequences in studied Loricariidae were proposed. Regarding H. zebra and H. sp. “pão”, we describe the events related to synapse and transcriptional activity during the meiotic cycle, which in both species showed 26 fully synapsed bivalents, with high gene expression only during zygotene and pachytene. Both Hypancistrus species could be used may be models for evaluating changes in spermatogenesis of Loricariidae.
Adverse Event Assessment and Reporting in Exercise Oncology: A Review
Authors: Dunn Riley M. , Hayes Sandra C. , Sandler Carolina X. , Spence Rosalind R. 
Published: October 2023

ABSTRACT
Exercise oncology trials report few adverse events, but the extent to which these adverse events are assessed and reported has yet to be quantified. The aim of this review was to evaluate adverse events assessment and reporting in exercise oncology trials that informed the American College of Sports Medicine’s 2019 Exercise Guidelines for Cancer Survivors, the leading guidelines document in exercise oncology. All trials that inform the Exercise Guidelines for Cancer Survivors were sourced for evaluation. In total, 231 clinical trials were identified. Approximately one-in-two trials included no detail of adverse event assessment methods and did not report intervention-related harms. Trials that described an adverse event assessment protocol reported higher numbers of adverse events compared with trials that did not. Many trials reported that adverse events were related to exercise; however, the majority of the trials did not define how this relationship was determined. Although the benefit of exercise postcancer is well established, findings from this review highlight the inadequacies of adverse events reporting within the exercise oncology field. The development and evaluation of a standardized adverse events assessment and reporting protocol for use in exercise oncology trials is needed.
Gender gaps in research: a systematic review
Authors: Rivera-Lozada Isabel Cristina , Rivera-Lozada Oriana , Escobar Gissel Carolina 
Published: October 2023

Background: Despite significant advancements in closing the global gender gap, there is still much progress to be made, particularly in the field of science and scientific research. Numerous studies have addressed this issue and identified a variety of factors that contribute to gender asymmetries in research. Methods: This study aimed to identify the determinants of gender gaps in scientific research present in the most cited studies of the past ten years as a first step towards closing these differences. Through a systematic literature review that incorporated the Proknow-C Knowledge Development Process and Constructivism methodology. Results: The results lead us to identify four dimensions to classify the determinants of the gaps in scientific research: academic supply, research policies, scientific production and researcher profile with their respective quantitative or qualitative indicators. Conclusions: As a potential basis for further modeling that offers greater analytical and correlational depth, as well as the identification of targeted strategies aimed at reducing gender gaps in research.
«QUIET» TRENDS IN HR MANAGEMENT: NEW TERMS OR NEW PROBLEMS?
Authors: Konovalova Valeriya 
Published: October 2023

The article is devoted to a study from the point of view of personnel management of the phenomenon of «quiet quitting» — a way of thinking in which employees deliberately limit their work activities to a description of their work, meet, but do not exceed pre-set expectations, never voluntarily take on additional tasks and do it all simply to maintain their current employment status, prioritizing their well-being over the achievement of organizational goals. Based on the generalization of the results of global and national studies, the main reasons for the spread of this phenomenon (including among young employees), as well as potential business risks that may arise as a result of «quiet quitting», if this phenomenon persists for a long time, are highlighted. The conclusion is substantiated that the phenomenon of «quiet quitting» is only partly a consequence of work during the pandemic, representing part of a larger picture of rethinking the institution of work. The interrelation of the problem of «quiet quitting» and the application of the practices of «quiet firing» and «quiet hiring» by organizations, their possible consequences for organizations and personnel are analyzed. Some proposals for the prevention of «quiet quitting» are presented, concerning the management of burnout, promotion of work-life balance, support for the mental health of employees and their development.
ECOSYSTEM APPROACH IN HIGHER EDUCATION IN RUSSIA IN THE ASPECT OF HUMAN RESOURCE MANAGEMENT
Authors: Ismagilova Galina , Lysenko E. 
Published: October 2023

The article is devoted to the consideration of the ecosystem approach as a new management paradigm. The need for ecosystem transformation is an attempt to ensure the sustainable functioning of an organized system by creating a system of permanent connections and continuous communication both in the external and internal environment. From the point of view of human resource management, the specifics of the ecosystem approach is the consideration of a person as a consumer, whose interests are placed at the center of change. In the ecosystem approach, the marketing focus on the person is maximally expressed. The authors show the features of ecosystem transformation in the system of higher education, based on the properties of the ecosystem: independence, uniqueness, interconnection, openness, and flexibility. The formation of an ecosystem of human resource management in the educational environment is considered as an urgent and demanded task.
CORPORATE CULTURE AND EMPLOYER BRAND IN MODERN CONDITIONS
Authors: Schanina E. , Schanina E. 
Published: October 2023

In the modern world, the successful development of any enterprise in any field depends on a number of factors, including the creation of a favorable corporate culture. Corporate culture is becoming an increasingly important aspect of doing business today. In this regard, the formation of a common vision of goals and objectives, a single strategy and sustainable values, which must be implemented at all levels and management structures, are of fundamental importance.
The article focuses on the fact that in modern conditions, the process of forming an effective corporate culture is associated with three important elements: external and internal HR-brand and social policy. The internal HR brand is a certain set of tools with which the strategy of staff retention and development is implemented, thereby developing employee loyalty. An internal HR brand is a powerful tool for creating and strengthening ties between employees and the employer, as well as ensuring their commitment to the company. In turn, an external HR brand is a set of activities aimed at attracting new personnel and strengthening the company's image in the external labor market, since it affects the perception of the company by potential employees and partners. Also, an equally important element of corporate culture is the social policy of the enterprise, which is aimed at improving working conditions and improving the quality of life of employees. Social policy includes elements such as bonuses, benefits and other programs that are aimed at showing the company's concern for its employees and creating a positive image. All these factors together give uniqueness to the corporate culture of the enterprise and influence its success in the long term.
Is Full Price the Full Story When Consumers Have Time and Budget Constraints?
Authors: Li Simin , Lariviere Martin A. , Bassamboo Achal 
Published: October 2023

Problem definition: A canonical model in service management assumes that consumers base the purchase of a service on its full price, that is, a linear combination of the monetary price and the expected time commitment. Although analytically convenient, when this assumption holds is an unexplored question. Methodology/results: We present a model of consumers allocating their time and money between working, overhead activities that do not provide utility, one continuous leisure activity, and one discrete service. Both continuous leisure activity and discrete service increase utility. Consumers can allocate any nonnegative amount of time or money to the leisure activity. Consumption of the discrete service requires a specific amount of time and money. We examine when the decision to purchase the discrete service depends only on its full price. We show that the full-price assumption does hold in specific cases. To be precise, it depends on how consumers are paid. If consumers completely control the amount of time that they work and earn a constant wage, they base their purchase decision on the full price. If, however, they must work a fixed shift length, then the assumption fails, and the full price is not sufficient to determine the consumer’s action. This leads to systematic differences in sellers’ strategies when they serve consumers with different compensation structures. If the consumers must work longer than would be optimal if they controlled their schedule and earned the same hourly wage, that is, the consumers are overemployed shift workers, then a seller restricts sales (relative to selling to consumers who control their work hours), and the system is less congested. The reverse holds if the consumers would prefer to work longer at the offered wage; that is, the consumers are underemployed shift workers. Managerial implications: We show that sellers who fail to take prevailing compensation structures of the community they serve into consideration experience significant revenue loss. In some cases, we see losses in consumer surplus and social welfare as well. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.0357 .
An evaluation of clinical fellow programmes in an acute teaching hospital trust
Authors: Galloway Rob , Castle John , Brown Amy , Richardson Daniel 
Published: October 2023

Background/Aims Clinical fellows support the hospital workforce while gaining experience in different specialities, research, leadership and teaching. The authors aimed to assess the impact of clinical fellow programmes in an acute teaching hospital trust. Methods An anonymous electronic service evaluation was sent to clinical fellows to investigate their views on whether the programme had improved patient safety, doctors' clinical performance, training and wellbeing. Thematic analysis was used to analyse the free-text responses. Results A total of 95 out of 144 clinical fellows responded to the evaluation survey. The clinical fellows believed that the programme had improved patient safety, clinical performance (time to manage acute patients), foundation and internal medicine training, undergraduate teaching and junior doctors' wellbeing. Four similar themes emerged from the free-text responses: career development, patient safety, training and doctors' wellbeing. Conclusions Clinical fellow programmes may improve patient safety, clinical performance, training, undergraduate education and doctors' wellbeing.
Sex differences in a murine model of asthma are time and tissue compartment dependent
Authors: Chiarella Sergio E. , Cuervo-Pardo Lyda , Coden Mackenzie E. , Jeong Brian M. , Doan Ton C. , Connelly Andrew R. , Rodriguez Raul I. , Queener Ashley M. , Berdnikovs Sergejs 
Published: October 2023

Asthma is a sexually dimorphic disease with greater documented prevalence and severity in women compared to men. Immunological parameters in mouse models of asthma also exhibit sexual dimorphism, with female mice typically having higher Th2 inflammation than male mice. Despite the standard choice of ovalbumin (OVA) murine models of asthma to study sex differences, there is little consensus across different studies in model design, timelines of sample collection and measured endpoints. To seek agreement in previous reports, we sought to resolve the time course of unfolding sex differences in a standardized 6-challenge OVA murine model of asthma. Immune responses in both lung tissue and airway compartments were quantified by multi-color flow cytometry. OVA-specific immunoglobulin E (IgE) and IgG1 were assayed by ELISA. Several lung tissue markers showed sexual dimorphism as measured by quantitative PCR (qPCR), including cytokines IL-4, IL-5, IL-13 and IL-10 and repair markers nestin and tenascin C. Although females had greater responses in the late phase of the model, male-biased dimorphism was evident in early responses. While females had greater adaptive responses (T and B cells) and higher eosinophils, male data suggested a stronger innate immune response (monocytes, neutrophils). Females had significantly higher OVA-specific IgE prior to the elicitation phase of the model, indicating early sex differences during sensitization. The same parameters frequently had opposing patterns of dimorphism in lung tissue vs. airway.

Conclusion
Sexual dimorphism in lung inflammation is both time and tissue compartment dependent. Spatiotemporal variability in sex differences in a murine model of asthma must be accounted for when planning experiments to model the sex bias in allergic inflammation.
Anne Monjaret – La Pin-up à l’atelier : ethnographie d’un rapport de genre
Authors: Couvry Camille 
Published: October 2023

Recensé : Anne Monjaret, La Pin-up à l’atelier : ethnographie d’un rapport de genre, Grâne, Créaphis Éditions, 2020, 152 p. (« Poche »).
Analyzing the articles published in the field of flute in Turkey
Authors: Tankız Kübra Dilek , Caf Güney 
Published: October 2023

This study, which aims to examine the articles published in the field of flute in Turkey in terms of various characteristics and to determine the current situation, was designed in descriptive survey model. The 103 articles, which can be accessed by typing the keyword "flute" in Google Scholar, Dergipark, Sobiad databases and Google search engine, were analyzed with a descriptive analysis approach according to the variables of "field, year, subject, method, number of authors, composer studied, journal in which it was published, index in which it was indexed". According to the results of the research, it was determined that the articles published in the field of flute showed a balanced distribution in terms of field type in the field of flute education and outside the field of flute education, were mostly published in 2019, focused on flute techniques, especially on work analysis and etude/method analysis, mainly adopted qualitative method and survey model as method type, mostly single-authored, and W.A. Mozart and E. Köhler were the leading composers covered in their subjects. In addition, it was concluded that these articles, which were published in 52 different journals, were mostly indexed in indexes other than international field indexes, TR Index and journals that are not indexed in any index, and least indexed in journals in ESCI- Scopus and H.W. Wilson indexes, which are known as international field indexes.
(Extended English summary is at the end of this document)

Özet
Türkiye’de flüt alanında yayımlanan makalelerin çeşitli özellikleri açısından incelenmesi ile mevcut durumunun belirlenmesi amacını taşıyan bu araştırma, betimsel tarama modelinde tasarlanmıştır. Google Akademik, Dergipark, Sobiad veri tabanlarına ve Google arama motoruna "flüt" anahtar kelimesi yazılarak ulaşılabilen 103 makale, betimsel analiz yaklaşımı ile "alan, yıl, konu, yöntem, yazar sayısı, işlenilen besteci, yayımlandığı dergi, tarandığı index (dizin) değişkenlerine göre dağılımları incelenmiştir. Araştırmanın sonuçlarına göre flüt alanında yayımlanan makalelerin alan türü bakımından flüt eğitimi alanında ve flüt eğitimi alanı dışında dengeli bir dağılım gösterdiği, en fazla 2019 yılında yayımlandığı, flüt teknikleri başta olmak üzere eser inceleme ve etüt/metot inceleme konuları üzerine yoğunlaştığı, ağırlıklı olarak nitel yöntemi ve yöntem türü olarak tarama modelini benimsediği, çoğunlukla tek yazarlı olduğu, konularında işlenen bestecilerin başında W.A. Mozart ve E. Köhler geldiği tespit edilmiştir. Ayrıca, 52 çeşit dergide yayımlanan bu makalelerin en çok sırasıyla uluslararası alan indexleri dışındaki diğer indexlerde, TR Dizin’de ve hiçbir indexte taranmayan dergilerde dizinlendiği; en az ise uluslararası alan indexleri olarak bilinen ESCI- Scopus ve H.W. Wilson indexleri kaspamındaki dergilerde tarandığı sonuçlarına ulaşılmıştır.