bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta‐analysis
Authors: Macedo Arthur C. , Bitencourt Fernando Valentim , Faria André Oliveira Vilela de , Bizzi Isabella Harb , Durço Daniella de Freitas Pereira Ângelo , Azevedo Claudia Britto , Morris Martin , Ferreira Karen dos Santos , De Souza Leonardo Cruz , Velly Ana Miriam 
Published: January 2024

BackgroundThis systematic review investigated the prevalence of orofacial pain in patients with mild cognitive impairment (MCI) or dementia.Materials and methodsThe search was conducted in five databases (Medline (Ovid), Embase (Ovid), CINAHL, Scopus and LILACS), in three grey literature sources and in included articles' reference lists. Three independent reviewers performed study selection, quality appraisal and data extraction. The risk of bias was assessed with the National Institutes of Health tool. Prevalence was calculated using the random‐effects model. Subgroup analysis and meta‐regression were used to explore the heterogeneity of results.ResultsThe database and grey literature search led to 12 246 results, from which nine studies were included; a further four were selected through citation searching. The total sample comprised 6115 patients with dementia and 84 with MCI. All studies had high risk of bias. The overall estimated pooled prevalence of orofacial pain among dementia participants was 19.0% (95% CI, 11.0%‐27.0%; I
2, 97.1%, P < .001). Only one study included MCI participants, among which the prevalence of orofacial pain was 20.5%. Subgroup analysis demonstrated that the different sources of diagnosis might explain the heterogeneity. A higher prevalence of orofacial pain was observed in dementia participants aged over 80 years or living in nursing homes. Meta‐regression analysis showed a nonlinear relationship between age and the prevalence of orofacial pain.ConclusionsThe pooled data from the primary studies revealed that 2 out of 10 patients with dementia have orofacial pain. Further research is needed to clarify the magnitude in individuals with MCI.
Non‐surgical correction of knee flexion deformity in persons with haemophilia: A staged multidisciplinary approach
Authors: Tilak Merlyn , John Judy Ann , Paul Arun , Srivastava Anumeha , Singh Divya , Rajendran Andriya , Thakkar Prince , Cherian Naveen , Albert Sandeep , Poonnoose Pradeep , Singh Abraham Sunder , Lakshmi Kavitha M. , Fouzia Nambiathayil Abubacker , Abraham Aby , Srivastava Alok 
Published: January 2024

AbstractIntroductionFlexion deformity of the knee is a common complication following recurrent haemarthrosis in persons with haemophilia (PWH) on episodic factor replacement therapy, restricting independent mobility. There is limited literature on the comprehensive management of this condition. This report provides the outcome of a staged multidisciplinary approach for the correction of knee flexion deformity (KFD) even in limited resource settings.Patients and methodsThe data of 49 consecutive PWH who were treated for KFD were analysed. The approach included graded physical therapy (PT), followed by serial casting and/or mobilisation under anaesthesia (MUA). MUA was done in carefully selected knees. Surgical correction was opted when non‐surgical methods failed.ResultsOf the 49 patients (55 knees), with a median KFD of 40 degrees (range: 10–90), 26/55 (47%) were corrected by graded PT. With serial casting, 9/19 (47%) knees had their KFD corrected. MUA was done for 11 knees of which five achieved correction (45%). Surgical correction was required for only seven knees (12.7%). Following this approach, KFD improved from 40 degrees (range: 10–90) to 15 degrees (range: 0–40), with only minor loss of flexion from 105 (range: 60–155) to 90 degrees (range: 30–150). Out of 55 KFD, 46 (83.6%) KFD were corrected; non‐surgical, 39 (70.9%) and surgery, seven (12.7%). The remaining patients (nine KFD; 16.4%) were able to achieve their functional goal despite not meeting the correction criteria.ConclusionThis study shows that in PWH, functionally significant KFD correction can be achieved in about 71%, through non‐surgical methods, even without prophylactic factor replacement.
Fostering metacognitive activities during job search: The Three Good Job Search Things intervention
Authors: Stremersch Jolien , Van Hoye Greet 
Published: January 2024

AbstractBased on principles from positive psychology and broaden‐and‐build theory, we examined whether conducting a Three Good Job Search Things intervention can increase metacognitive activities among job seekers. We further theorize that positive affect (i.e., activating and deactivating) serves as a mediating mechanism for the effect of the reflection intervention on metacognitive activities. We designed a randomized control group pretest–posttest experimental study with three groups (i.e., Three Good Job Search Things, active control, and passive control) and two measurement times (N = 116). Results show that the Three Good Job Search Things intervention increased job seekers' metacognitive activities as compared with the passive control group, but not as compared to the active control group. However, the active control group results did not differ significantly from the passive control group. The effects of the intervention on job seekers' metacognitive activities were not mediated by enhanced positive affect. This study contributes to the job search literature by expanding our understanding of how metacognition during job search can be improved by reflecting upon one's job search process.
The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double‐blind, multicenter study
Authors: Zhuang Qianjun , Liao Aijun , He Qingling , Liu Chengxia , Zheng Changqing , Li Xing , Liu Youli , Wang Bangmao , Liu Side , Zhang Yan , Lin Rong , Chen Huixin , Deng Min , Tang Yanping , He Chiyi , Dai Weijie , Tang Haitao , Gong Lei , Li Liangping , Xu Baohong , Yang Changqing , Zhou Bingxi , Su Dongxing , Guo Qinghong , Li Bin , Zhou Yongjian , Wang Xiaoyang , Fei Sujuan , Wu Huili , Wei Sichen , Peng Zhihong , Wang Jianning , Li Yanqing , Wang Hong , Deng Tianwei , Ding Shigang , Li Fangfang , Chen Minhu , Xiao Yinglian 
Published: January 2024

AbstractBackground and AimFexuprazan is a novel potassium‐competitive acid blocker (P‐CAB). This study aimed to explore the noninferior efficacy and safety of fexuprazan to esomeprazole in treating erosive esophagitis (EE).MethodsThis was a phase III, randomized, double‐blind multicenter study. Patients with endoscopically confirmed EE were randomized to receive fexuprazan 40 mg or esomeprazole 40 mg once a daily for 4–8 weeks. The healing rates of EE, symptom response, GERD‐health‐related quality life (GERD‐HRQL), and treatment‐emergent adverse events (TEAEs) were compared between fexuprazan group and esomeprazole group.ResultsA total of 332 subjects were included in full analysis set (FAS) and 311 in per‐protocol set (PPS). The healing rates of fexuprazan and esomeprazole groups at 8 weeks were 88.5% (146/165) and 89.0% (145/163), respectively, in FAS and 97.3% (145/149) and 97.9% (143/146), respectively, in PPS. Noninferiority of fexuprazan compared with esomeprazole according to EE healing rates at 8 weeks was demonstrated in both FAS and PPS analysis. No significant difference was found between groups in EE healing rates at 4 weeks, symptom responses, and changes of GERD‐HRQL. The incidence of drug‐related AEs was 19.4% (32/165) in fexuprazan arm and 19.6% (32/163) in esomeprazole arm.ConclusionThis study demonstrated noninferior efficacy of fexuprazan to esomeprazole in treating EE. The incidence of TEAEs was similar between fexuprazan and esomeprazole.Trial registration number NCT05813561.
Carbon footprint and cost reduction by endoscopic grading of gastric intestinal metaplasia using narrow‐band imaging
Authors: Cho Jun‐Hyung , Jin So‐Young , Park Suyeon 
Published: January 2024

AbstractBackground and AimGastric intestinal metaplasia (GIM) is a high‐risk factor for the development of gastric cancer. Narrow‐band imaging (NBI) enables endoscopic grading of GIM (EGGIM). In the era of climate change, gastrointestinal endoscopists are expected to reduce greenhouse gas emissions and medical waste. Based on the diagnostic performance of NBI endoscopy, this study measured the environmental impact and reduced cost of implementing EGGIM during gastroscopy.MethodsUsing NBI endoscopy in 242 patients, EGGIM classification and operative link on GIM (OLGIM) staging were prospectively performed in five different areas (lesser and greater curvatures of the corpus and antrum, and the incisura angularis). We estimated the environmental impact and cost reduction of the biopsy procedures and pathological processing if EGGIM were used instead of OLGIM.ResultsThe diagnostic accuracy of NBI endoscopy for GIM was 93.0–97.1% depending on the gastric area. When a high EGGIM score ≥ 5 was the cut‐off value for predicting OLGIM stages III–IV, the area under the curve was 0.862, sensitivity was 81.9%, and specificity was 90.4%. The reduction in the carbon footprint by EGGIM was −0.4059 kg carbon dioxide equivalents per patient, equivalent to 1 mile driven by a gasoline‐powered car. The cost savings were calculated to be $47.36 per patient.ConclusionsEGGIM is a reliable method for identifying high‐risk gastric cancer patients, thereby reducing the carbon footprint and medical costs in endoscopy practice.
Trade‐Off Theory for Dual Holders
Authors: LINDSET SNORRE , NYGÅRD GUTTORM , PERSSON SVEIN‐ARNE 
Published: January 2024

AbstractA dual holder simultaneously owns (private) debt and equity in the same firm. Private debt has a tax advantage, a positive cashflow, which incentivizes its use. This cashflow leads to a lower net cost of debt, which again reduces default risk as well as the cost of external debt. The usual trade‐off between tax benefits and bankruptcy costs is altered. Debt priority affects both financing and default decisions. We find that an enterprise‐value maximizing firm should issue senior, external debt and junior, private debt, rather than debt with pari‐passu priority. Our analysis further highlights that tax authorities can effectively curtail the tax‐motivated use of private debt through straightforward measures.
Precautionary Money Demand in a Cash‐in‐Advance Model
Authors: SALAS SERGIO 
Published: January 2024

AbstractWhile numerous studies in monetary economics explore inflation, interest rates, stock returns, and money velocity, a model seamlessly linking these interactions remains elusive. One crucial omission in this literature is idiosyncratic precautionary money demand, a prominent feature in the data. This paper addresses this gap by presenting a simple model where precautionary money demand arises from heterogeneous household liquidity needs. Despite its intricate heterogeneity, the model allows straightforward aggregation, enabling analysis of its implications for household portfolios composed of cash, government bonds, and equities. The empirical analysis spans the period 1959.I–2022.I. Notably, the model captures crucial time‐series properties that models without the idiosyncratic element fail to achieve.
Mesenteric fibrosis in patients with small intestinal neuroendocrine tumors is associated with enrichment of alpha‐smooth muscle actin‐positive fibrosis and COMP‐expressing stromal cells
Authors: Graf Sebastian D. , Keber Corinna U. , Hattesohl Akira , Teply‐Szymanski Julia , Hattesohl Sophia , Guder Marc , Gercke Norman , Di Fazio Pietro , Slater Emily P. , Jesinghaus Moritz , Denkert Carsten , Bartsch Detlef K. , Lehman Bettina 
Published: January 2024

AbstractNeuroendocrine tumors of the small intestine (SI‐NETs) often develop lymph node metastasis (LNM)‐induced mesenteric fibrosis (MF). MF can cause intestinal obstruction as well as ischemia and render surgical resection technically challenging. The underlying pathomechanisms of MF are still not well understood. We examined mesenteric LNM and the surrounding stroma compartment from 24 SI‐NET patients, including 11 with in situ presentation of strong MF (MF+) and 13 without MF (MF−). Differential gene expression was assessed with the HTG EdgeSeq Oncology Biomarker Panel comparing MF+ with MF− within LNM and paired stromal samples, respectively. Most interesting differentially expressed genes were validated by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) in combination with validation of associated protein levels utilizing immunohistochemistry (IHC) staining of MF+ and MF– formalin‐fixed, paraffin‐embedded (FFPE) patient samples. Overall, 14 genes measured with a 2549‐gene expression panel were differentially expressed in MF+ patients compared to MF−. Of those, nine were differentially expressed genes in LNM and five genes in the stromal tissue (>2‐fold change, p < .05). The top hits included increased COMP and COL11A1 expression in the stroma of MF+ patients compared to MF−, as well as decreased HMGA2, COL6A6, and SLC22A3 expression in LNM of MF+ patients compared to LNM of MF− patients. RT‐qPCR confirmed high levels of COMP and COL11A1 in stroma samples of MF+ compared to MF− patients. IHC staining confirmed the enrichment of α‐smooth muscle actin‐positive fibrosis in MF+ compared to MF− patients with corresponding increase of COMP‐expressing stromal cells in MF+. Since COMP is associated with the known driver for fibrosis development transforming growth factor beta and with a cancer‐associated fibroblasts enriched environment, it seems to be a promising new target for MF research.
Empowered or overwhelmed? Procrastination extinguishes the positive effects of work flexibility on work–family conflict
Authors: Boyar Scott L. , Smit Brandon W. , Maertz Carl P. 
Published: January 2024

AbstractProviding flexibility at work is the most pervasive tool for organizations to help employees manage the work–family (WF) interface. Extant research, however, indicates that flexibility does not consistently reduce WF conflict. This paper reports on two studies that contribute to our understanding of how, and for whom, perceived work flexibility improves these outcomes. We extend work on the mechanisms by which flexibility influences outcomes and extend conservation of resources theory using choice overload theory to understand the boundaries of flexibility as a positive resource, specifically, in the form of procrastination. In Study 1, we found that perceived work flexibility was negatively related to subjective work demand for those low on procrastination. In Study 2, we replicate these effects and extend them by finding that effects of flexibility on WF conflict were mediated by its influence on subjective work demand. We discuss the implications of these findings for future research and practice around flexibility in the WF interface.
Pain in your day? Get sleep treatment anyway! The role of pain in insomnia treatment efficacy in women veterans
Authors: Erickson Alexander J. , Ravyts Scott G. , Dzierzewski Joseph M. , Carlson Gwendolyn C. , Kelly Monica R. , Song Yeonsu , McGowan Sarah Kate , Mitchell Michael N. , Washington Donna L. , Yano Elizabeth M. , Alessi Cathy A. , Martin Jennifer L. 
Published: January 2024

SummaryInsomnia and pain disorders are among the most common conditions affecting United States adults and veterans, and their comorbidity can cause detrimental effects to quality of life among other factors. Cognitive behavioural therapy for insomnia and related behavioural therapies are recommended treatments for insomnia, but chronic pain may hinder treatment benefit. Prior research has not addressed how pain impacts the effects of behavioural insomnia treatment in United States women veterans. Using data from a comparative effectiveness clinical trial of two insomnia behavioural treatments (both including sleep restriction, stimulus control, and sleep hygiene education), we examined the impact of pain severity and pain interference on sleep improvements from baseline to post‐treatment and 3‐month follow‐up. We found no significant moderation effects of pain severity or interference in the relationship between treatment phase and sleep outcomes. Findings highlight opportunities for using behavioural sleep interventions in patients, particularly women veterans, with comorbid pain and insomnia, and highlight areas for future research.
Effect of volume of instillate on the diagnostic utility of bronchoalveolar lavage galactomannan in patients with suspected chronic pulmonary aspergillosis—A pilot study
Authors: Ajayababu Anuj , Singh Gagandeep , Meena Ved Prakash , Upadhyay Ashish Datt , Rana Bhaskar , Sethi Prayas , Prakash Bindu , Singh Amandeep , Vyas Surabhi , Sinha Sanjeev , Xess Immaculata , Wig Naveet , Kabra Sushil Kumar , Ray Animesh 
Published: January 2024

AbstractBackgroundBronchoalveolar lavage (BAL) galactomannan (GM) is commonly used to diagnose Aspergillus‐related lung diseases. However, unlike serum GM, which is measured in undiluted blood, BAL‐GM is estimated using variable aliquots and cumulative volume of instillates during bronchoscopy.ObjectiveSince different studies have reported varying diagnostic accuracy and cut‐offs for BAL‐GM in CPA, we hypothesized that the total volume of instillate and ‘order/label’ of aliquots significantly affects the BAL‐GM values, which was evaluated as part of this study.Patients & MethodsWe obtained 250 BAL samples from 50 patients (five from each) with suspected chronic pulmonary aspergillosis. BAL fluid was collected after instilling sequential volumes of 40 mL of normal saline each for the first four labels and a fifth label was prepared by mixing 1 mL from each of the previous labels. The GM level of each label was measured by PLATELIA™ ASPERGILLUS Ag enzyme immunoassay. This study measured the discordance, level of agreement, diagnostic characteristics (sensitivity, specificity and AUROC) and best cut‐offs for BAL‐GM in the different aliquots of lavage fluid.ResultsThe study population, classified into CPA (28%) and non‐CPA (72%) groups, based on ERS/ESCMID criteria (excluding BAL‐GM) were not different with respect to clinico‐radiological characteristics. The discordance of BAL‐GM positivity (using a cut‐off of >1) between the serial labels for the same patient ranged between 10% and 22%, while the discordance between classification using BAL‐GM positivity (using a cut‐off of ≥1) and clinic‐radio‐microbiological classification ranged between 18% and 30%. The level of agreement for serial labels was at best fair (<0.6 for all except one ‘label’). The AUROC for the serial samples ranged between 0.595 and 0.702, with the ‘40 mL and the ‘mix’ samples performing the best. The best BAL‐GM cut‐off also showed significant variation between serial labels of varying dilutions (Range:1.01 ‐ 4.26).InterpretationThis study highlights the variation in BAL‐GM measured and the ‘positivity’ between different ‘labels’ of aliquots of BAL, with the first aliquot and the mixed sample showing the best performances for diagnosis of CPA. Future studies should attempt to ‘standardise’ the instilled volume for BAL‐GM estimation to standardise the diagnostic yield.
Analysis of joint protein expression profile in anterior disc displacement of TMJ with or without OA
Authors: Zou Luxiang , Yang Kaiwen , Yu Yeke , Wang Chuyao , Zhao Jieyun , Lu Chuan , He Dongmei 
Published: January 2024

AbstractObjectiveAnterior disc displacement (ADD) is a common clinical issue and may cause osteoarthritis (OA). However, the research of protein changes in synovial fluid as disease development marker and potential treatment clue is still insufficient.Materials and MethodsWe conducted the high‐resolution mass spectrometry (MS) of synovial fluid collected from 60 patients with normal disk position to ADD and ADD with osteoarthritis (OA). The proteins with significant changes among the 3 groups were analyzed by biological information and further validated by in primary rat condyle chondrocytes and OA animal model.ResultsFGL2, THBS4, TNC, FN1, OMD etc. were significantly increased in ADD without OA (p < 0.05), which reflected the active extracellular matrix and collagen metabolism. FGFR1, FBLN2, GRB2 etc. were significantly increased in ADD with OA group (p < 0.05), which revealed an association with apoptosis and ferroptosis. Proteins such as P4HB, CBLN4, FHL1, VIM continuously increase in the whole disease progress (p < 0.05). Both the in vitro and in vivo results are consistent with protein changes detected in MS profile.ConclusionThis study firstly provides the expression changes of proteins from normal disc condyle relationship toward ADD with OA, which can be selected and studied further as disease progress marker and potential treatment targets.
Ecological novelty at the start of the Cambrian and Ordovician radiations of echinoderms
Authors: Novack‐Gottshall Philip M. , Purcell Jack , Sultan Ali , Ranjha Isa , Deline Bradley , Sumrall Colin D. 
Published: January 2024

AbstractThe Cambrian and Ordovician radiations marked the origins of all major echinoderm clades and established their Phanerozoic ecological blueprint. Recent claims of modest innovation of early echinoderms and other animals suggest constraints on novelty during the origins of phyla. Here, we document the life‐habit richness, body size, tiering, habitat usage, mobility, diet and foraging habits of 366 Cambrian–Ordovician echinoderm genera across a time‐scaled phylogeny to identify the timing and impact of novelty. Most early echinoderms were sedentary, filter‐feeding microbivores, and their body sizes, diets and modes of locomotion were largely unchanged through time, despite major volatility in taxonomic composition. Cambrian echinoderms lived close to the seafloor, with stylophorans first evolving semi‐infaunality. Many Ordovician echinoderms lived farther from the seafloor, with more complex filter‐feeding organs and tiering structure, often using other organisms as substrates. Mobile carnivores and mass‐feeders emerge then, too, across diverse asterozoans and echinozoans. Most of these novelties coincide with the origins of individual clades during the early and late Cambrian (Terreneuvian/Series 2 and Furongian), and 10–20 million years pass before most become ecologically important. Life‐habit evolution within most taxa involved new variations in these traits, with crinoids and asterozoans better able to shift strategies. The Ordovician radiation records more new variability in pre‐existing Cambrian life habits rather than radical re‐invention, with important novelties (like mobile carnivory and mass‐feeding, increased height off the seafloor, and biotic substrates) becoming ecologically more impactful. Taxa with these strategies were those best able to capitalize on the newly heterogeneous Ordovician world.