bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
Authors: Gálvez-Silva Matías , Arros Patricio , Berríos-Pastén Camilo , Villamil Aura , Rodas Paula I. , Araya Ingrid , Iglesias Rodrigo , Araya Pamela , Hormazábal Juan C. , Bohle Constanza , Chen Yahua , Gan Yunn-Hwen , Chávez Francisco P. , Lagos Rosalba , Marcoleta Andrés E. 
Published: October 2023

Abstract

Background
The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from sequence type 23 (ST23) and having a K1 capsule, have been associated with severe community-acquired invasive infections. Although hvKp reports were initially restricted to Southeast Asia and primarily antibiotic-sensitive, carbapenem-resistant hvKp infections are reported worldwide. Here, within the carbapenemase production Enterobacterales surveillance system headed by the Chilean Public Health Institute, we describe the isolation in Chile of a high-risk ST23 dual-carbapenemase-producing hvKp strain, which carbapenemase genes are encoded in a single conjugative plasmid.
Results
Phenotypic and molecular tests of this strain revealed an extensive resistance to at least 15 antibiotic classes and the production of KPC-2 and VIM-1 carbapenemases. Unexpectedly, this isolate lacked hypermucoviscosity, challenging this commonly used hvKp identification criteria. Complete genome sequencing and analysis confirmed the K1 capsular type, the KpVP-1 virulence plasmid, and the GIE492 and ICEKp10 genomic islands carrying virulence factors strongly associated with hvKp. Although this isolate belonged to the globally disseminated hvKp clonal group CG23-I, it is unique, as it formed a clade apart from a previously reported Chilean ST23 hvKp isolate and acquired an IncN KPC-2 plasmid highly disseminated in South America (absent in other hvKp genomes), but now including a class-I integron carrying blaVIM−1 and other resistance genes. Notably, this isolate was able to conjugate the double carbapenemase plasmid to an E. coli recipient, conferring resistance to 1st -5th generation cephalosporins (including combinations with beta-lactamase inhibitors), penicillins, monobactams, and carbapenems.
Conclusions
We reported the isolation in Chile of high-risk carbapenem-resistant hvKp carrying a highly transmissible conjugative plasmid encoding KPC-2 and VIM-1 carbapenemases, conferring resistance to most beta-lactams. Furthermore, the lack of hypermucoviscosity argues against this trait as a confident hvKp marker. These findings highlight the rapid evolution towards multidrug resistance of hvKp in Chile and globally, and the importance of conjugative plasmids and other mobile genetic elements in this convergence. In this regard, genomic approaches provide valuable support to monitor and obtain essential information on these priority pathogens and mobile elements.
Study on adsorption capacity of corn stalks in decreasing the turbidity of Babura river water with batch operation
Authors: Haryanto Bode , Batubara Fatimah , Ginting Ella Theresia , Situmorang Dicky A. D. , Alexander Vikram 
Published: October 2023

The adsorbent is a solid substance that can absorb certain components from the liquid phase. Most of the adsorbents are porous materials and the adsorption process takes place, especially in the porous wall or certain location inside that particle. The main objective of this research is to study the influence of the adsorbent’s surface area based on shape variation from corn stalk with adsorption ability to reduce the water river’s turbidity, the influence of time with adsorption capacity in reducing river water’s turbidity, the influence of adsorbent with water river and adsorption capacity, and defining adsorption kinetics from corn stalks. The shape of corn stalks that have been used such as spherical, half of spherical shape, and quarter of spherical shape. The volume of the sample is 250 mL. The measurement time is 300 minutes. The mass variations that have been used are 10 g, 15 g, and 20 g. The variation of sample takeover in the morning, afternoon, and evening. The measurement of adsorbent adsorption capacity in term of decreasing the turbidity of Babura River’s water is done by inputting the adsorbent into the sample, then the measurement of the water’s turbidity proceed by using a turbidity meter. The analysis result for the influence of the adsorbent’s surface area in decreasing Babura River’s water in the shape’s variation from spherical, half of spherical shape, and quarter of spherical shape is obtained in quarter of spherical shape. The highest amount of adsorbent in decreasing the turbidity of Babura River’s water is 20 g. Adsorption kinetics that has been used in the measurement of decreasing Babura River’s water turbidity is second order kinetics
New Mineral Names: Heavy metal and minerals from China
Authors: Celestian Aaron J. 
Published: October 2023

Abstract
This issue of New Mineral Names summarizes new species that contain toxic heavy metals and rare earth elements with a partial focus on new minerals found in China. All these new minerals have potential uses for environmental and technological applications, and their origins reflect historical mining or cultural significance. Here we look at fluorbritholite-(Nd), napoliite, scenicite, evseeite, haitaite-(La), dongchuanite, liguowuite, and gysinite-(La).
Advances in Stimuli-responsive Hydrogels for Tissue Engineering and
Regenerative Medicine Applications: A Review Towards Improving Structural
Design for 3D Printing
Authors: Sithole Mduduzi Nkosinathi , Mndlovu Hillary , du Toit Lisa C. , Choonara Yahya Essop 
Published: October 2023

Abstract:
The physicochemical properties of polymeric hydrogels render them attractive for the development
of 3D printed prototypes for tissue engineering in regenerative medicine. Significant effort has been made to
design hydrogels with desirable attributes that facilitate 3D printability. In addition, there is significant interest
in exploring stimuli-responsive hydrogels to support automated 3D printing into more structurally organised
prototypes such as customizable bio-scaffolds for regenerative medicine applications. Synthesizing stimuli-responsive
hydrogels is dependent on the type of design and modulation of various polymeric materials to open
novel opportunities for applications in biomedicine and bio-engineering. In this review, the salient advances
made in the design of stimuli-responsive polymeric hydrogels for 3D printing in tissue engineering are discussed
with a specific focus on the different methods of manipulation to develop 3D printed stimuli-responsive
polymeric hydrogels. Polymeric functionalisation, nano-enabling and crosslinking are amongst the most
common manipulative attributes that affect the assembly and structure of 3D printed bio-scaffolds and their stimuli-
responsiveness. The review also provides a concise incursion into the various applications of stimuli to
enhance the automated production of structurally organized 3D printed medical prototypes.
Oxidation of Polycyclic Aromatic Hydrocarbons with Mono-Oxygen Donors
Catalysed by Triaryl-Manganese(III) Corroles
Authors: Dandia Anshu , Chauhan Shive M.S. , Milton Marilyn Daisy 
Published: October 2023

Abstract:
The oxidation of polycyclic aromatic hydrocarbons (PAH) with mono-oxygen donors such as iodosylbenzene,
hydrogen peroxide and tert-butyl hydroperoxide in the presence of selected 5,10,15-triarylmanganese(
III) corroles as catalysts were examined under different reaction conditions. The effect of reaction
conditions on triaryl-manganese(III) corroles catalysts and oxidants is discussed. It was observed that in a solvent
system consisting of a mixture of dichloromethane and acetonitrile, the oxidation of anthracene with tertbutyl
hydroperoxide catalysed by tri(aryl)manganese(III)corroles worked better than with hydrogen peroxide or
iodosylbenzene as the oxidants. The oxidation of anthracene with hydroxo-manganese(IV)corroles was also
examined in organic solvents under mild conditions. UV-Vis and other spectroscopic data were used to determine
the oxidative mechanism for the oxidation of anthracene and other polycyclic aromatic hydrocarbons with
mono-oxygen donors catalysed by triaryl-manganese(III)corroles.
Artificial Intelligence in Drug Formulation and Development: Applications and
Future Prospects
Authors: Noorain  , Srivastava Varsha , Parveen Bushra , Parveen Rabea 
Published: October 2023

Abstract:
Artificial Intelligence (AI) has emerged as a powerful tool in various domains, and the field of drug
formulation and development is no exception. This review article aims to provide an overview of the applications
of AI in drug formulation and development and explore its future prospects. The article begins by introducing the
fundamental concepts of AI, including machine learning, deep learning, and artificial neural networks and their
relevance in the pharmaceutical industry. Furthermore, the article discusses the network and tools of AI and its
applications in the pharmaceutical development process, including various areas, such as drug discovery, manufacturing,
quality control, clinical trial management, and drug delivery. The utilization of AI in various conventional
as well as modified dosage forms has been compiled. It also highlights the challenges and limitations associated
with the implementation of AI in this field, including data availability, model interpretability, and regulatory
considerations. Finally, the article presents the future prospects of AI in drug formulation and development,
emphasizing the potential for personalized medicine, precision drug targeting, and rapid formulation optimization.
It also discusses the ethical implications of AI in this context, including issues of privacy, bias, and accountability.
Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease:
A Bibliometric-based Literature Review
Authors: Cui Jing , Li Yiwen , Zhu Mengmeng , Liu Yanfei , Liu Yue 
Published: October 2023

Objective:
To investigate the current status and development trend of research on exosomes
in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics.

Methods:
Research articles on exosomes in CVD published up to April 2022 were retrieved from the
Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and
VOSviewer 1.6.18 were used for bibliometric analysis and result visualization.

Results:
Overall, 256 original research publications containing 190 fundamental research publications
and 66 clinical research publications were included. "Extracellular vesicle" was the most frequent
research keyword, followed by "microrna," "apoptosis," and "angiogenesis." Most publications
were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7,
2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction
and stroke were the most popular topics and that exosomes and their contents, such as microRNAs
(miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis,
promotion of angiogenesis, and protection of cardiomyocytes.

Conclusion:
Research on exosomes in CVD has attracted considerable attention, with China having
the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate
the progression of CVD through biological processes, such as the inflammatory response, autophagy,
and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using
miRNAs in exosomes as disease markers for diagnosis could become a future trend.
CK2B is a Prognostic Biomarker and a Potential Drug Target for
Hepatocellular Carcinoma
Authors: Dai Huiru , Liu Minling , Pan Yuxi , Li Tingwei , Pan Yihang , Chen Zhe-Sheng , Li Jing , Liu Yuchen , Fang Shuo 
Published: October 2023

Background:
Although casein kinase II subunit beta (CK2B) was previously reported
to be involved in human cancers, such as hepatocellular carcinoma (HCC), there has been no
systematic assessment of CK2B in HCC.

Objective:
To assess the potential function of CK2B as a prognostic biomarker and possible
druggable target in HCC.

Methods:
The Cancer Genome Atlas database was accessed to investigate the potential oncogenic
and prognostic roles of CK2B in HCC. Diverse analytical methods were used to obtain a
fuller understanding of CK2B, including CIBERSORT, The Tumor Immune Estimation Resource
(TIMER), gene set enrichment analyses (GSEA), Kyoto Encyclopedia of Genes and Genomes
(KEGG), and gene ontology (GO). Furthermore, the Comparative Toxicogenomic Database
(CTD) was used to identify potential drugs to treat CK2B-overexpressing HCC. Patents for
these drugs were reviewed using Patentscope® and Worldwide Espacenet®.

Results:
Upregulated CK2B expression was markedly associated with more aggressive pathological
features, including G3, G4 (vs. G1, G2), and T2, T3 (vs. T1). Kaplan–Meier survival
curves indicated that patients with HCC with higher expression of CK2B had worse overall survival
(P = 0.005), progression-free interval (P = 0.001), and disease-specific survival (P =
0.011). GO and KEGG analysis revealed that CK2B dysregulation affects mitotic chromosome
condensation, protein stabilization and binding, regulation of signal transduction of p53 class
mediator, and cancer-related pathways. GSEA identified six well-known pathways, including
MAPK, WNT, Hedgehog, and TGFβ signaling pathways. Finally, CTD identified six compounds
that might represent targeted drugs to treat HCC with CK2B overexpression. A review
of patents indicated these compounds showed promising anticancer results; however, whether
CK2B interacts with these drugs and improves drug outcomes for patients with HCC was not
confirmed.

Conclusion:
CK2B is a biomarker for HCC prognosis and could be a potential new drug target.
Moreover, the association between infiltrating immune cells and CK2B in the HCC tumor microenvironment
might provide a solid basis for further investigation and a potent strategy for
immunotherapy of HCC.
Data Science Curriculum
Authors: O'Leary Kayla , Rorissa Abebe , Kim Jeonghyun 
Published: October 2023

With an increase in technology use and rapid generation of information and data, graduate-level programs with data science curricula have grown exponentially to match the demand for information professionals with data-related skills. However, a gap has formed between skills learned in school and skills information professionals need post-graduation. Previous research indicates a skills gap among data scientists who lack LIS training in areas like data curation, preservation, etc., which data science programs should address (Ortiz-Repiso et al., 2018). This study, as part of a broader project funded by IMLS (Grant # RE-250066-OLS-21), attempts to address current and future workforce demands in data librarianship and analytics, employer skill demand, and acquisition of skills.
This poster reports on part of the larger project - content analysis of 294 distinct graduate program curricula involving significant data science coursework in 43 LIS schools and iSchools across North America. After collecting over 1,000 data science/librarianship-related courses from institutional websites, we coded them into seven categories using their titles and descriptions. Data analysis, curation, governance, and discovery were the most popular subjects, followed by data professions, miscellaneous courses, and data assessment. In conjunction with job ad analysis and surveys of stakeholders in data science and librarianship education by others, our study could serve as input for graduate programs/curricula design. Results from our study will increase understanding of the nature and structure of data science curricula in iSchools and LIS departments while giving students requisite skills to meet future needs as data science professionals/data librarians.
Flashing the Hazard Lights
Authors: Youngman Tyler , Appedu Sarah , Tacheva Zhasmina , Patin Beth 
Published: October 2023

The increasing relevance of service algorithms and emerging technologies has landed many professions at a ‘disruptive’ crossroads. With the popular emergence of ChatGPT, a large language model from OpenAI designed to interact with users through conversations, discourses surrounding its ubiquity, potentiality, and adoption have captivated audiences. We argue that the unpredictable nature and changing capabilities of ChatGPT and other algorithmic technologies are another critical juncture in the advancement of LIS education. When given a library-oriented prompt, ChatGPT manifested biases that we normally interrogate in our ethical and professional conduct in the delivery of library services, further demonstrating the risk of algorithmic technologies in reproducing and amplifying marginalization and replicating harm. Hence, we ‘flash the hazard lights’, so to speak, and urge a more critical analysis and precautionary consideration of the social, technological, and cultural harms enabled or perpetuated by the uncritical adoption of ChatGPT and other algorithmic technologies.
Digital Cultural Heritage
Authors: Dunbar Anthony , Gosart Ulia 
Published: October 2023

Session 1: Preserving Memories during the Wartime: Ukraine
Ulia Gosart, Assistant Professor, School of Information, San Jose State University
The first session focuses on pedagogical strategies supportive of utilizing and preserving Digital Cultural Heritage. Presented in a case study manner, the panel connects experiences of digital preservation with development of relevant curricula. The case studies include preserving memories during wartime in Ukraine; African American cultural heritage in the southwest of the US; conserving traditional knowledge (TK) and indigenous knowledge (IK) within Indigenous communities in Western Pacific. Each Case can lead to innovative pedagogy possibilities be they emerging as components of traditional educational programs; or exist as elements of innovative teaching centers, and/or growing interdisciplinary collaborations.

Session 2: African American Digital Cultural Heritage through the San Antonio Public Library
DL Grant jr, Carver Library Branch Manager, San Antonio, TX
Libraries now transcend more traditional services and resources offering informal gatherings and community events that uniquely uplift the various communities they serve. History harvests, as they are sometimes known, celebrate the cultural heritage of the users leading to preservation of archival matter via digitization. This San Antonio based case study touches on two such services: 1) oral history events that weave stories of the past and document as well as entertain; and 2) a funeral program collection gone digital, making researching African American cultural heritage easier to research. With so much as a cellphone phone one can connect to electronic representations that document families, communities, rituals, institutions and genealogy, to name a few. These library programs encourage donations and help to ensure survivability of cultural heritage.

Session 3: Digital Cultural Heritage and Our Existential Threat
Cecilia Salvatore: Professor, School of Information Studies, Dominican University
In communities where their existence is threatened by global climate change, the need for a digital cultural heritage repository is stark and poignant. For example, the small island nations in the Western Pacific, which are responsible for only 0.03% of global greenhouse gas emissions, and yet they are disproportionally facing many of the threats of climate change head on. The communities on these islands are not simply passive towards what’s going on. They want to be equipped with the resources to tackle climate change. And they know that their own traditional knowledge and indigenous knowledge, which has been passed on for hundreds of years, is the most critical resource. The presenter describes TK/IK in the Pacific Islands, some current practices for preserving this knowledge, and the role of digital cultural heritage tools and methodologies.
The Importance of Learning the Difference Between Copyright and Wrong
Authors: Ocepek Melissa , Benson Sara , Cheng Siyao , Saunders Laura , Lipinski Tomas 
Published: October 2023

Copyright impacts all aspects of librarianship and most aspects of the wider information professions, yet courses that specifically address the legal rights and limitations of U.S. Federal Copyright law are not well represented in Library and Information Science (LIS) curriculum (Cross & Edwards, 2011; Schmidt & English, 2015). Studies have found a lack of copyright familiarity let alone literacy among librarians and LIS students surrounding many important copyright topics regarding open licensing, orphan works, and digital institutional repositories (Estell & Saunders, 2016; Saunders & Estell, 2019). The recent update to ALA’s Core Competencies has added additional copyright focused language to note that librarians should have foundational skills to “Understand the legal framework in which libraries operate, including laws relating to copyright and fair use…” (ALA, 2023). The need for this material is quite clear and yet many library and LIS programs have not addressed this notable gap in their curriculum.
This panel of copyright experts, researchers, and course instructors is designed to help identify the roadblocks that have led to a dearth of copyright focused courses, and to opportunities for change using existing resources. The aim of this panel is to inspire all in attendance to work with in their institutions to advocate for more copyright focused instruction throughout LIS.
The panel will consist of five brief five-minute talks from all panelists followed by a moderated discussion with the audience to map out the limitations and opportunities of copyright education for already existing LIS curriculum. The panel will close with a presentation of resources that can be used to improve copyright education including open educational resources and other no-cost material. Closing the session, the panelists will ask audience members to share their contact information, to provide continued support in bringing curricula change to their home programs or departments. We hope this panel will help create a community around this topic and become a regular topic at ALISE and similar conferences.