bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autistic recognition from EEG signals by extracted features from several time series models
Authors: Rajabioun Mehdi 
Published: February 2024

Abstract
Autism is a neurological and psychological disorder that typically manifests in childhood and persists into adulthood. It is characterized by atypical social, behavioral, and communication skills, as well as diminished attention to the surrounding environment. The detection and recognition of autism can contribute to the prevention of its development and the enhancement of social and communicational abilities. Various methods are employed for autism recognition, including questionnaire tests and neurological techniques. One such neuroimaging method is electroencephalography (EEG), which records the brain's electrical activities through sensors placed on the scalp. This paper proposes a method for identifying individuals with autism using EEG signals and features extracted from a multivariate autoregressive moving average (MVARMA) and multivariate integrated autoregressive(ARIMA) models. The approach begins by estimating active sources through source localization methods, followed by the application of a dual Kalman filter to estimate source activity. Subsequently, the MVARMA and ARIMA models are applied to the EEG sensor and active source data, enabling the calculation of model parameters. Principal component analysis is then utilized to select important parameters, and a K nearest neighbor classifier is employed to classify participants as either autistic or neurotypical. The results demonstrate superior classification performance, achieving higher accuracy compared to alternative methods. The proposed method yields superior classification outcomes when compared to other approaches, as it exhibits improved classification measures.
Package W2CWM2C: description, features and applications
Authors: Martínez Josué Polanco- , Fernández-Macho Javier 
Published: February 2024

Abstract
This article describes new graphical tools that help with the interpretation of wavelet correlation and cross-correlation analysis, in both bivariate and multivariate cases. We have created an R package called W2CWM2C with the following main functions: Wavelet (Cross) Correlation and Wavelet Multiple (Cross) Correlation. To illustrate its strengths, we use data from several European Union stock market indices, comparing the new graphical output with the classical plots.
The study of the efficiency evaluation of the ventilation system of the poultry house in the summer
Authors: Hajiyev Rovshan , Huseynova Mehriban , Taghiyev Urfan , Mammadov Gabil , Allahverdiyeva Gahira 
Published: February 2024

With the onset of cold weather, heat transfer through the walls and especially the roofs of bird rooms, unlike in the summer period, increases significantly, which leads to a sharp decrease in warm indoor air. Therefore, in order to maintain the regulatory conditions of the ventilation system, it is reduced to a transitional mode, and then to a minimum ventilation mode. Low ventilation repeatability limits inside the building determine the minimum volume of air supplied by the ventilation system. The economic and production efficiency of poultry farming is related to the premises and climatic conditions, which can seriously affect the well-being of broilers. Heat stress contributes to behavioral, physiological and biochemical changes in broilers, which leads to economic losses.
The purpose of this study is to influence the annual efficiency of the poultry house ventilation system, mainly in summer, in order to evaluate the efficiency during the reconstruction of the cooling system, that is, to improve the ventilation system of the room, as well as to give an economic assessment of waste disposal technology.
Energy– and resource-saving, environmentally friendly technologies and technological tools, plastic-type recuperators, a bird droppings removal system, as well as lighting and irrigation processes were taken as the object of the study. In conducting our research, let’s use classical and special methods, including a decomposition method for analyzing the functional use of recycling technology, a logical and linguistic method for assessing the safety of nitrogen during disposal, microclimate technology, nutrition and storage.
Based on the mathematical model, a computer research methodology was developed to improve the energy efficiency of the poultry house. Using a computer program, the number of LEDs (α=200, I0=20 cd) for an enclosure measuring 66×12 m is N=273 pieces, and the number of LEDs (α=200, I0=20 cd) for a building measuring 78×18 m is N=259 pieces. The design parameters of the illuminators are justified
Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential
Prognostic and Immune Infiltration-associated Biomarker
Authors: Guo Yangyang , Zhang Rongrong , Xu Hongjie , Hong Kai , Cen Kenan , Mai Yifeng , Wu Zhixuan 
Published: February 2024

aims:
To investigate the expression of HMGN1 in different types of cancer and its potential role in cancer diagnosis and prognosis.

background:
The High Mobility Group N (HMGN) family of genes includes the High Mobility Group Nucleosomal Binding Domain 1 Gene (HMGN1), which is crucial for epigenetic regulation. However, the specific function of HMGN1 in cancer development is not known.

objective:
The High Mobility Group N (HMGN) family of genes includes the High Mobility Group Nucleosomal Binding Domain 1 Gene (HMGN1), which is crucial for epigenetic regulation. However, the specific function of HMGN1 in cancer development is not known.

method:
Raw data on HMGN1 expression were procured from Genotype-Tissue [removed]GTEx), the University of Alabama- Birmingham CANcer data analysis Portal (UALCAN), and The Cancer Genome Atlas (TCGA). Thereafter, the pan-cancer analysis was implemented to understand the HMGN1 expression patterns, prognostic value, and immunological features. Furthermore, the Gene Set Enrichment Analysis (GSEA) was executed with the help of the R language. In addition, the relationship between HMGN1 and the sensitivity of antitumor drugs was also determined. Finally, real-time PCR (RT-PCR) experiments were conducted to validate the differential expression of HMGN1.

result:
The findings of the pan-cancer analysis revealed that HMGN1 was upregulated in several solid tumors and was strongly associated with pathological staging and poor prognosis in several cancers. In addition, HMGN1 was found to be involved in regulating the TIME. The findings of the GSEA enrichment analysis indicated that HMGN1 assisted in the regulation of oncogenic processes, especially metabolic and immune pathways. Furthermore, HMGN1 expression was linked to microsatellite instability (MSI) and tumor mutational burden (TMB) in a variety of tumors. RT-PCR assays indicated that HMGN1 was significantly overexpressed in the gastric and breast cancer cell lines and tissues.

conclusion:
This study highlighted the potential of the epigenetic regulator, HMGN1, as an oncogene and a biomarker for pan-cancer analysis.

other:
None
A Five-gene Signature based on MicroRNA for Predicting Prognosis
and Immunotherapy in Stomach Adenocarcinoma
Authors: Wang Tianwei , Chen Piji , Li Tingting , Li Jianong , Zhao Dong , Meng Fanfei , Zhao Yujie , Zheng Zhendong , Liu Xuefei 
Published: February 2024

Aims:
We aimed to classify molecular subtypes and establish a prognostic gene
signature based on miRNAs for the prognostic prediction and therapeutic response in
Stomach adenocarcinoma (STAD).

Background:
STAD is a common diagnosed gastrointestinal malignancy and its heterogeneity
is a big challenge that influences prognosis and precision therapies. Present study
was designed to classify molecular subtypes and construct a prognostic gene signature
based on miRNAs for the prognostic prediction and therapeutic response in STAD.

Objective:
The objective of this study is to investigate the molecular subtypes and prognostic
model for STAD.

Methods:
A STAD specific miRNA-messenger RNA (mRNA) competing endogenous
RNA (ceRNA) network was generated using the RNA-Seq and miRNA expression profiles
from The Cancer Genome Atlas (TCGA) database, in which miRNA-related mRNAs
were screened. Molecular subtypes were then determined using miRNA-related genes.
Through univariate Cox analysis and multivariate regression analysis, a prognostic model
was established in GSE84437 Train dataset and validated in GSE84437 Test, TCGA,
GSE84437 and GSE66229 datasets. Immunotherapy datasets were employed for assessing
the performance of the risk model. Finally, quantitative reverse transcription-polymerase
chain reaction (qRT-PCR) was applied to validate the expression of hub genes used for
the risk score signature.

Results:
We constructed a ceRNA network containing 84 miRNAs and 907 mRNAs and
determined two molecular subtypes based on 26 genes from the intersection of TCGASTAD
and GSE84437 datasets. Subtype S2 had poor prognosis, lower tumor mutational
burden, higher immune score and lower response to immunotherapy. Subtype S1 was
more sensitive to Sorafenib, Pyrimethamine, Salubrinal, Gemcitabine, Vinorelbine and
AKT inhibitor VIII. Next, a five-gene signature was generated and its robustness was validated
in Test and external datasets. This risk model also had a good prediction performance
in immunotherapy datasets.

Conclusion:
This study promotes the underlying mechanisms of miRNA-based genes in
STAD and offers directions for classification. A five-gene signature accurately predicts
the prognosis and helps therapeutic options.
Mannose: A Promising Player in Clinical and Biomedical Applications
Authors: Chen Sijing , Wang Kana , Wang Qiao 
Published: February 2024

:
Mannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula
but a different atom arrangement, contributing to its specific biological functions. Widely distributed
in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose
plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for
immune regulation and glycosylation processes, underscore the significance of mannose in these
physiological activities. The clinical and biomedical applications of mannose are diverse, encompassing
its anti-inflammatory properties, potential to inhibit bacterial infections, role in metabolism regulation,
and suggested involvement in alleviating diabetes and obesity. Additionally, mannose shows
promise in antitumor effects, immune modulation, and the construction of drug carriers, indicating a
broad spectrum of therapeutic potential. The article aims to present a comprehensive review of mannose,
focusing on its molecular structure, metabolic pathways, and clinical and biomedical applications,
and also to emphasize its status as a promising therapeutic agent.
Risk Factors and Prognosis of Early Neurological Deterioration after
Bridging Therapy
Authors: Xie Yiju , Li Shengyu , Liu Liuyu , Tang Shiting , Liu Yayuan , Tan Shuangquan , Liang Zhijian 
Published: February 2024

Background:
Early neurological deterioration (END) after bridging therapy (BT) of
acute ischemic stroke (AIS) patients is associated with poor outcomes.

Objective:
We aimed to study the incidence, risk factors and prognosis of END after BT.

Methods:
From January to December 2021, the clinical data of AIS patients treated by BT (intravenous
thrombolysis with alteplase prior to mechanical thrombectomy) from three comprehensive
stroke centers were analyzed. Patients were divided into non-END group and END
group according to whether they developed END within 72 hours of symptom onset. Modified
Rankin scale (mRS) was used to assess the patient’s prognosis at 90 days, and favorable outcomes
were defined as mRS≤2. The incidence of END was investigated, and binary logistic regression
analysis was used to explore its associated factors.

Results:
The incidence of END after BT was 33.67%. The eligible 90 patients included 29 cases
in the END group and 61 cases in the non-END group. Multivariate Logistic regression analysis
showed that increase of systolic blood pressure (SBP) (OR=1.026, 95%CI:1.001-1.051, p
=0.043), higher level of blood glucose at admission (OR=1.389, 95%CI:1.092-1.176, p =0.007)
and large artery atherosclerosis (LAA) subtype (OR=8.009, 95%CI:2.357-27.223, p =0.001)
were independent risk factors of END. Compared with the non-END group, the END group had
significantly lower rates of good outcomes (6.90% versus 65.57%, p =0.001) while higher rates
of mortality (44.83% versus 4.92%, p =0.001).

Conclusion:
It was found that the incidence of END after BT in AIS patients was 33.67%. An
increase in SBP, higher glucose levels at admission, and LAA were independent risk factors of
END that predicted a poor prognosis.
Association between Oxidative Balance Score and Severe Headache or
Migraine among American Adults A Cross-Section Study
Authors: Geng Dandan , Liu Huanxian , Wang Haoyuan , Dong Zhao , Wang Hebo 
Published: February 2024

Background:
Migraine is implicated in oxidative stress. The oxidative balance score
(OBS) assesses the combined impact of diet and lifestyle on oxidative and antioxidant balance in
diseases. However, the association between OBS and migraine remains underexplored.

Objective:
We aimed to examine the relationship between OBS and severe headaches or migraines
among American adults

Methods:
This cross-sectional study utilized data from the National Health and Nutrition Examination
Survey (NHANES) 1999-2004, defining severe headaches or migraine via self-reports
and calculating OBS from 16 diaries and 4 lifestyle factors. Multivariable weighted logistic regression
models were used to explore the OBS-migraine relationship, with stratified analysis for
result validation.

Results:
The study included 6,653 participants (average age 45.6, 52.1% male), and 19.1% reported
severe headaches or migraines. There was a significant inverse association between OBS
and severe headache or migraine, with an adjusted odds ratio (OR) of 0.97 (95% [confidence
interval] CI: 0.96, 0.98, p < 0.001). The highest OBS tertile had an adjusted OR of 0.58 (95%
CI: 0.47, 0.73) compared to the lowest. This pattern was consistent across sexes, with an adjusted
OR of 0.98 (0.95, 1.00) in males and 0.97 (0.95, 1.00) in females. The adjusted OR for migraine
was 0.61 (0.44, 0.87) and 0.54 (0.37, 0.79) in the highest tertile for males and females,
respectively.

Conclusion:
The study highlights a significant association between OBS and severe headaches
or migraines, suggesting the potential role of oxidative stress in these conditions. The findings
emphasize the importance of a balanced, antioxidant-rich diet and lifestyle in managing severe
headaches or migraine.
Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral
Venous Reflux in Patients with Recent Small Subcortical Infarction
Authors: Wu Zhengrong , Zhang Ke , Zong Ce , Liu Hongbing , Wang Yanhong , Xu Yuming , Gao Yuan 
Published: February 2024

Background:
Research has linked enlarged perivascular spaces (EPVS) to cerebral
venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear
whether this association exists in recent small subcortical infarct (RSSI) patients.

Objective:
This study aimed to investigate the correlation between EPVS and CVR in patients
with RSSI.

Method:
This study included 297 patients, selected from patients with RSSI in the lenticulostriate
artery admitted to the Department of Neurology of the First Affiliated Hospital of Zhengzhou
University. CVR was assessed by time-of-flight magnetic resonance angiography (TOF-MRA).
The relationship between EPVS and CVR was studied using multiple logistic regression analysis.

Results:
This study included patients with an average age of 59.84±12.27 years, including 201
males (67.7%). CVR was observed in 40 (13.5%) patients. Compared to the group without CVR,
the proportions of male patients and patients with a history of smoking and drinking were higher
in the CVR group. The proportions of high-grade EPVS in the centrum semiovale region [23
cases (57.5%) vs. 108 cases (42.0%), p =0.067] and the basal ganglia region [30 cases (75.0%)
vs. 133 cases (51.8%), p =0.006] were higher in the CVR group. After multiple logistic regression
analysis, high-grade EPVS in the basal ganglia region was still associated with CVR (OR,
2.68; 95% CI, 1.22-5.87; p =0.014).

Conclusion:
In the population with RSSI, EPVS in basal ganglia is significantly associated with
CVR, suggesting a close relationship between venous dysfunction and the formation of EPVS.
A Case Report of Chronic Inflammatory Demyelinating Polyneuropathy
following COVID-19 Vaccination
Authors: Karbasforooshan Hedyieh , Amini Shahram , Boostani Reza , Mousavian Pourandokht , Hosseinjani Hesamoddin 
Published: February 2024

Introduction::
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a peripheral
polyneuropathy. Chronic damage to neuronal myelin by the immune system results in inflammation
and demyelination of the peripheral nervous system. Several side effects have been reported
with Coronavirus disease 2019 (COVID-19) vaccines. There are some reports of vaccineinduced-
CIDP. In this study, we described the occurrence of CIDP in a patient with a history of receiving
the first dose of a COVID-19 vaccine, Sputnik V.

Case Report::
We presented a patient receiving the COVID-19 vaccine Sputnik V two weeks before
progressive flaccid tetraparesis and dysautonomia. He was first diagnosed with Guillain-
Barre Syndrome (GBS). Two episodes of worsening the weakness occurred within 8 weeks
from the onset of the disease, and the treatment was repeated as GBS-Treatment-related Fluctuations
(TRF) and relapse. Also, a few relapses happened eight weeks after the disease's onset.
Hence, he was diagnosed with “acute-onset CIDP”. The patient received several intravenous immunoglobulin
(IVIG) courses as maintenance therapy. No further deterioration was reported during
the follow-up.

Conclusion::
Post-vaccination GBS is a known phenomenon. However, there are several reports
of vaccine-induced-CIDP. This is the first reported case of acute-onset CIDP associated with the
Sputnik V vaccine in Iran. Subsequent studies are required to determine the definite relationship
between COVID-19 vaccination and CIDP.
Probiotics as an Adjunct Approach to the Prevention and Treatment of
Colon Cancer: A Review
Authors: Kumar Akash , Goyal Nandani , Pramanik Jhilam , Bawa Yashna , Singh Sudarshan , Prajapati Bhupendra 
Published: February 2024

Abstract::
One out of every six people in the world is suffering from cancer disease. The major
causes of cancer are high consumption of tobacco, high body mass index, and alcoholic beverages
with low intake of a healthy diet and limited physical activity. Colon cancer is one of the leading
causes of cancer-related morbidity worldwide. In the past few years, probiotics have drawn a lot
of interest as potential preventive and therapeutic anticancer agents. This literature review addressed
both human and animal research that has explored the association between probiotics and
colon cancer. Probiotic administration has remarkable potential for the prevention and treatment
of colon cancer through various mechanisms such as inhibiting the growth of cancer cells via apoptosis,
improving immune activity, restoring gut microbiota, improving intestinal barrier properties,
synthesizing anticarcinogenic compounds, and degrading carcinogenic compounds. Therefore, probiotics
emerge as an adjunct therapy, holding the potential to significantly reduce the risk of colorectal
cancer.
Enhanced CT Findings in a Case of Recurrent Pelvic Follicular Dendritic Cell
Sarcoma
Authors: Feng Wenhan , Yu Mingchuan , Li Haibo 
Published: February 2024

Introduction::
Follicular Dendritic Cell Sarcomas (FDCS)was first found in 1986; the specificity of the disease is its rarity, with an incidence of only 0.4%,
numerous doctors for its lack of understanding, the accuracy of imaging diagnosis is not great, which is easy to delay the treatment. This article
summarizes several characteristic imaging manifestations of FDCS to provide imaging physicians with an understanding of the imaging properties
of this rare disease. When faced with complex cases, the radiologist can consider this disease and include it in the differential diagnosis. FDCS
occurs mainly in lymph nodes, mainly in the head and neck. The main symptoms are fatigue, local pain, or painless mass. The treatment method is
not uniform, but scholars agree that we should strive for the opportunity of surgery as much as possible.

Case Presentation::
This paper reported a case of FDCS with pelvic recurrence 3 years after surgery. The patient was suspected to have lymphoma by postoperative
pathology in the local hospital, and it is recommended that the patient be reexamined regularly. A soft tissue mass was recently found again in the
left pelvic cavity. After an enhanced CT examination, the radiologist was skeptical of the previous diagnosis of lymphoma. Subsequently, a needle
biopsy was performed at Peking University Shougang Hospital. The pathological results rejected the prior diagnosis of lymphoma after
consultation with additional hospitals, and the patient was diagnosed with FDCS.

Conclusions::
The imaging manifestations of FDCS lack absolute specificity, but it also has imaging characteristics, such as large areas of necrosis in the huge
mass, rough mass calcification in the mass, enhanced scan showed “fast in and slow out” mode, and there were blood vessels in the tumor. FDCS
mainly occurs in lymph nodes and is easily misdiagnosed as GIST, inflammatory myoblastoma, lymphoma, etc. Radiologists should continue to
collect cases of this disease and include suspected cases in the differential diagnosis in clinical work.
Quality Evaluation of Banlangen Granule based on Bioassays of
Anti-influenzal and Anti-inflammatory Effects
Authors: Qian Xiu-yu , Zhang Ming-lu , Wu Yan-Lin , Ma Shuang-cheng , Liu Jin-mei , Kuang Yan-hui , Nie Li-xing 
Published: February 2024

Objective::
In order to control the quality better, this study aimed to develop two bioassay
methods of Banlangen Granule (BLGG) based on its anti-influenza activity and antiinflammatory
activity and to verify the necessity of established methods by relating the results
tested by chemical methods.

Methods:
First, the bioassay methods for determining the biopotency of the anti-influenza effect
and anti-inflammatory activity were established and applied, taking neuraminidase and cyclooxygenase-
2 as disease targets, respectively. Secondly, the ultra-high-performance liquid
chromatography coupled photo-diode array detector (UPLC-PDA) technique was used to perform
fingerprints and quantify chemical compounds. Finally, the correlation analysis was performed
on the results of bioassay methods and chemical methods to assist in choosing the effective
quality markers for the BLGG.

Results::
Two accurate, stable, and repeatable bioassay methods were developed and applied to
the determination of 57 batches of samples. The chemical fingerprints and contents of seven
quality compounds were obtained based on UPLC-PDA methods. From the results of correlation
analysis, the highest intensity correlation between these quality markers was medium with
a r=0.495 (P<0.01), which indicates the need for establishing a bioassay method for BLGG.

Conclusion::
This present work illuminated that bioassay methods can be a great means to
evaluate the quality of BLGG effectively and also provided a paradigm case for the quality
control of other traditional Chinese medicine preparations.