bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case Control Study on Prevalence, Sleep Disorder & Life Style of Children with Autism of Bangladesh
Authors: Alam Md Fakhrul , Sarwar A S M , Razzak Khandarker Sabit Bin , Amin Sayadat , Akter Shamima , Bushra Anika 
Published: October 2023

Background: This research analyzes the sleeping conditions of children with autism spectrum disorder (ASD) and examines the relationship between common sleep disorders, core symptoms, and developmental phases.
Objectives: To investigate the prevalence, sleep disorder & life style of children with autism of Bangladesh.
Methods: This case-control study used qualitative and quantitative (Mix-Method) approaches. Sources were primary and secondary. The study conducted in 08 districts in Bangladesh such as Dhaka, Chittagong, Jassore, Mymensingh, Rajshahi, Rangpur, Barisal, Sylhet. This study included 400 school going children and the age group was within 3-12 years old and 200 children were from Autistic Spectrum Disorder and 200 children were from Traditionally Developed Children.
Results: In case group among the 200 respondents who were the guardian of the children of ASD highest (74%) were mother followed by (24.50%) were father and only (1.50%) were other like brother or sister. In control group (TDC) highest (71%) respondents were mother followed by (16.50%) were father and only (12.50%) were from other like sister or brother. Highest (58.50%) ASD children were within the age of 9 to 12 years and 32.50% were 6 to 8 years old. Only 9% were from (3 to 5) years old. In control group highest (58%) TDC were within the age of 9 to 12 years and 29% were 6 to 8 years old. Only 13% were from (3 to 5) years old. Highest (67%) were male and (33%) were female on the other hand in control group (54%) were male and (46%) were female. In case group, highest (50.50%) were classical autism and highest (69.00%) were referred for test. According to children’s response to social response’s in case group rarely response was 35%, sometimes response was 27.5%, often response was 14.0%, maximum time response was 11.5%, always response was 12.0%. Chi-Square Tests results shows that both slip duration and taking pill among ASD children and TDC are significant which indicate there is certain association of ASD and sleep disorder.
Conclusion: ASD Children have certain sleep disorder and challenging life style. Early detection by using effective diagnosis and test required for ASD. ASD children need special care with proper lifestyle management. This study observed that the ASD children have certain creativity especially in handicraft, art and cultural activities. Proper skill development training can improve their creativity. Therefore it is necessary to support them from all part of society.
Bangladesh Medical Res Counc Bull 2023; 49(2): 134-142
Ammatillisen koulutuksen merkitykset ammattikoulutaustaisten yliopisto-opiskelijoiden näkökulmasta
Authors: Isopahkala-Bouret Isopahkala-Bouret , Haltia Nina 
Published: October 2023

Artikkelissa tarkastellaan sitä, millaisia merkityksiä ammattikoulutaustaiset yliopisto-opiskelijat antavat aiemmille ammatillisille opinnoilleen ja millaisia institutionaalisia rajoja näissä merkityksenannoissa rakentuu. Lähestymme ammatillista koulutusta kenttänä, jonka suhdetta muihin koulutuksen muotoihin ja yhteiskuntaan määritellään erilaisten institutionaalisten kategorisointien avulla. Nämä tuottavat kulttuurisesti jaettuja käsityksiä ammatillisesta koulutuksesta, jotka heijastuvat opiskelijoiden tulkintoihin siitä, kenelle ammatillinen koulutus on tai ei ole tarkoitettu ja millaiset jatkokoulutusvalinnat ovat heille mahdollisia. Tutkimuksessa haastateltiin 33 ammattikoulutaustaista yliopisto-opiskelijaa. Analyysin perusteella ammatillinen koulutus voitiin nähdä 1) tavoitteellisena askeleena kohti omia päämääriä, 2) vääränä valintana, 3) itsestäänselvyytenä tai 4) välttämättömänä pahana. Opiskelijoiden merkityksenannot tekivät näkyviksi ammatillisen koulutuksen institutionaalisia rajoja. Ne orientoivat eri tavoin jatkokoulutukseen, mutta kielteisetkään opiskelukokemukset eivät olleet estäneet yliopisto-opintoja myöhemmin elämässä. Tutkimus osallistuu keskusteluun koulutuspolitiikan linjauksista ja avartaa käsityksiä ammatillisen tutkinnon suorittaneiden jatko-opintomahdollisuuksista.
PARALELISASI CASCADE LEARNING MENGGUNAKAN FITUR LOCAL BINARY PATTERN UNTUK DETEKSI BOLA MULTI-POLA
Authors: Setiawan Dedi Setiawan 
Published: October 2023

Pemrosesan paralel ialah komputasi dua atau lebih proses secara bersamaan dengan tujuan mempersingkat waktu eksekusi proses. Pemrosesan paralel dapat dilakukan dengan menggunakan teknik multi-threading, yaitu menjalankan beberapa thread dengan tugas-tugas tertentu secara bersamaan. Dalam Kontes Robot Sepak Bola Indonesia, robot wajib memiliki kemampuan mengenali bola melalui sensor kamera berupa kmaera digital PS3 Eye, dalam hal ini robot mengenali bola dengan cara serial oleh karena itu peneliti mengembangkan proses deteksi bola tersebut menggunakan pemrosesan paralel dengan membagi data (dekomposisi data) menjadi beberapa bagian untuk diproses oleh thread yang bertugas melakukan proses deteksi bola. Dari hasil pengujian yang dilakukan pada robot yang memiliki mini komputer Intel NUC i5 dengan kecepatan 2,5 GHz, didapatkan hasil bahwa strategi deteksi bola dengan mengaktifkan fungsi deteksi bola mendapat speedup sebesar 1,16 dan efisiensi sebesar 29%. Sedangkan strategi deteksi bola tanpa mengaktifkan fungsi deteksi bola mendapat speedup sebesar 1,15 dan efisiensi sebesar 28,72%.
Training on Instilling Waste Sorting Behavior to Optimize Waste Processing in Desa Bogares Kidul Tegal
Authors: Rabbani Latifa 
Published: October 2023

Bogares Kidul is an industrial center village with a substantial residential populations, that generates a significant volume of waste. However, the waste bank in Bogares Kidul remains underutilized, as trash continues throw away without any sorting process. Sorting waste behavior is a behavior that involves the categorization and separation of waste by type that presents a potential solution to the waste processing challenges in Bogares Kidul. Consequently, a waste sorting training program held involving 26 participants who are PKK cadre members with an average age of 42.5 years. The research encompasses a series of critical steps, including needs analysis, the formulation of approaches and objectives, training program design, and subsequent implementation and evaluation. Evaluation procedures involve assessing participants' knowledge, attitudes, and abilities through questionnaires and their practical skills through hands-on exercises. Furthermore, PKK cadre members as role models play a pivotal role in enhancing motivation among local families and residents, fostering the practice of waste sorting, and ultimately optimizing waste processing efforts in the community. Keyword: Waste Processing, Waste Sorting Behavior, Bogares Kidul Village
Os violões “Modelo Abreu” presentes na ETMD Ivanildo Rebouças da Silva de Cubatão-SP
Authors: Messias dos Santos Jéssica , Moraes Taffarello Tadeu 
Published: October 2023

Este trabalho pretende apresentar uma parte da história que contempla a parceria de Sérgio Abreu e a empresa Tranquillo Giannini S/A na construção dos violões conhecidos popularmente como “Modelo Abreu” e como tais instrumentos foram parar na Escola Técnica de Música e Dança Ivanildo Rebouças da Silva, em Cubatão. O objetivo deste artigo é investigar a história e uso desses instrumentos, desde a aquisição pela ETMD até a forma com que foram usados e conservados pela escola. Para isso, foi feita uma pesquisa qualitativa que consistiu, além de um resgate histórico em jornais, revistas e documentos históricos, entrevistas com professores e coordenadores que fizeram parte dessa história ou que atualmente trabalham com esses instrumentos. Ao final dessa pesquisa, foi possível obter toda a trajetória histórica de vida desses violões, desde quando surgiram até quando foram adquiridos pela escola.
Layer-dependent excellent thermoelectric materials: from monolayer to trilayer tellurium based on DFT calculation
Authors: Zhang Kexin , Yang Rennong , Sun Zhehao , Chen Xihao , Huang Sizhao , Wang Ning 
Published: October 2023

Monoelemental two-dimensional (2D) materials, which are superior to binary and ternary 2D materials, currently attract remarkable interest due to their fascinating properties. Though the thermal and thermoelectric (TE) transport properties of tellurium have been studied in recent years, there is little research about the thermal and TE properties of multilayer tellurium with interlayer interaction force. Herein, the layer modulation of the phonon transport and TE performance of monolayer, bilayer, and trilayer tellurium is investigated by first-principles calcuations. First, it was found that thermal conductivity as a function of layer numbers possesses a robust, unusually non-monotonic behavior. Moreover, the anisotropy of the thermal transport properties of tellurium is weakened with the increase in the number of layers. By phonon-level systematic analysis, we found that the variation of phonon transport under the layer of increment was determined by increasing the phonon velocity in specific phonon modes. Then, the TE transport properties showed that the maximum figure of merit (ZT) reaches 6.3 (p-type) along the armchair direction at 700 K for the monolayer and 6.6 (p-type) along the zigzag direction at 700 K for the bilayer, suggesting that the TE properties of the monolayer are highly anisotropic. This study reveals that monolayer and bilayer tellurium have tremendous opportunities as candidates in TE applications. Moreover, further increasing the layer number to 3 hinders the improvement of TE performance for 2D tellurium.
Participation in genetic screening: testing different outreach methods across a diverse hospital system based patient population
Authors: Dickey Lindsay , Gronowski Ben , Jones Kyle , Rinaldi J. B. , Emery Kate , Clemens Jon , Gordon Ora , Vartanian Keri 
Published: October 2023

Introduction: Genomics has the potential to transform medicine by identifying genetic risk factors that predispose people to certain illnesses. Use of genetic screening is rapidly expanding and shifting towards screening all patients regardless of known risk factors, but research is limited on the success of broad population-level outreach for genetic testing and the effectiveness of different outreach methods across diverse populations. In this study, we tested the effectiveness of Digital Only (emailing and texting) and Brochure Plus Digital (mailed brochure, emailing, and texting) outreach to encourage a diverse patient population to participate in a large hospital system’s whole genome sequencing program.Methods: Disproportionate stratified sampling was used to create a study population more demographically diverse than the eligible population and response rates were analyzed overall and by demographics to understand the effectiveness of different outreach strategies.Results: 7.5% of all eligible patients enrolled in the program. While approximately 70% of patients invited to complete genetic testing identified in their EHR as being Hispanic, Black or African America, Asian, or another non-White race, these patients generally enrolled at lower rates than the overall population. Other underrepresented groups had higher enrollment rates including people with Medicaid coverage (8.7%) and those residing in rural areas (10.6%). We found no significant difference in enrollment rates between our Digital-Only and our Brochure Plus Digital outreach approaches in the overall population, but enrollment rates were significantly higher for Asian patients and patients who resided in rural areas in the Brochure Plus Digital group. Across both outreach approaches, links provided in emails were most commonly used for enrollment.Discussion: Our study reveals expected enrollment rates for proactive outreach by a hospital system for genetic testing in a diverse population. As more hospital systems are adopting population-scale genetic testing, these findings can inform future outreach efforts to recruit patients for genetic testing including those patients traditionally underrepresented in genomics.
Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression
Authors: Zhu Jinfeng , Chen Qitong , Zeng Liyun , Gao Hongyu , Wu Tong , He Yeqing , Xu Jiachi , Pang Jian , Peng Jing , Deng Yueqiong , Han Yi , Yi Wenjun 
Published: October 2023

BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division. Recent research shows that ORC6 regulates the advancement of multiple cancers; however, it remains unclear what regulatory impact it has on the tumor immune microenvironment.MethodsUnpaired Wilcoxon rank sum and signed rank tests were used to analyze the differences in the expression of ORC6 in normal tissues and corresponding tumor tissues. Multiple online databases have evaluated the genetic alterations, protein expression and localization, and clinical relevance of ORC6. To evaluate the potential prognostic impact and diagnostic significance of ORC6 expression, we carried out log-rank, univariate Cox regression, and receiver operating characteristic curve analysis. The ICGC-LIRI-JP cohort, CGGA-301 cohort, CGGA-325 cohort, CGGA-693 cohort, and GSE13041 cohort were used for external validation of the study findings. The associations between ORC6 expression and immune cell infiltration, immune checkpoint expression, and immunotherapy cohorts was further analyzed. To explore the functional and signaling pathways related to ORC6 expression, gene set enrichment analysis was performed. To clarify the expression and function of ORC6 in hepatocellular carcinoma (LIHC) and glioma, we conducted in vitro experiments.ResultsExpression of ORC6 is upregulated in the majority of cancer types and is associated with poor patient prognosis, notably in cases of LIHC and gliomas. In addition, ORC6 may be involved in multiple signaling pathways related to cancer progression and immune regulation. High expression of ORC6 correlates with an immunosuppressive state in the tumor microenvironment. The results of further immunotherapy cohort analysis suggested that patients in the ORC6 high-expression group benefited from immunotherapy. Inhibiting ORC6 expression suppressed the proliferative and migratory abilities of LIHC and glioma cells.ConclusionHigh expression of ORC6 may be used as a biomarker to predict the poor prognosis of most tumor patients. The high expression of ORC6 may be involved in the regulation of the tumor immunosuppressive environment, and it is expected to become a molecular target for inhibiting tumor progression.
Disease progression in patients with usual interstitial pneumonia and probable UIP patterns on computed tomography with various underlying etiologies: a retrospective cohort study
Authors: Yang Shuqiao , Wang Jing , Sun Di , Wang Yiran , Xue Changjiang , Ye Qiao 
Published: October 2023

BackgroundUsual interstitial pneumonia (UIP) is a pattern of interstitial pneumonia that is caused by different etiologies. This study aimed to investigate the transplant-free survival (TFS) and the decline in forced vital capacity (FVC) of the patients with UIP and probable UIP patterns on CT caused by various underlying conditions.MethodsA retrospective cohort study was conducted, enrolling patients with interstitial lung disease exhibiting a CT pattern consistent with UIP or probable UIP. Clinical and prognostic data of patients categorized by the etiology were compared.ResultsA total of 591 patients were included and classified into the following groups: idiopathic pulmonary fibrosis (IPF) (n = 320), connective tissue disease (CTD)-UIP (n = 229), asbestosis-UIP (n = 28), and hypersensitivity pneumonitis (HP)-UIP (n = 14). Advanced age, elevated levels of serum cytokeratin fraction 21-1 and percentage of neutrophils in bronchoalveolar lavage were observed in all groups. IPF patients showed a more rapid decline in FVC (133.9 mL/year) compared to CTD-UIP (24.5 mL/year, p = 0.001) and asbestosis-UIP (61.0 mL/year, p = 0.008) respectively. Sub-analysis of CTD-UIP revealed that patients with rheumatoid arthritis (RA)-UIP (88.1 mL/year) or antineutrophil cytoplasmic antibody-associated vasculitis (AAV)-UIP (72.9 mL/year) experienced a faster deterioration in FVC compared to those with primary Sjögren’s syndrome (pSS)-UIP (25.9 mL/year, p &lt; 0.05). Kaplan–Meier curves showed that IPF had the poorest TFS (median 55.9 months), followed by HP-UIP (57.5 months), CTD-UIP (66.7 months), and asbestosis-UIP (TFS not reached). RA-UIP or AAV-UIP did not exhibit any prognostic advantages compared to IPF, while asbestosis-UIP and pSS-UIP showed better survival rates.ConclusionPatients with UIP caused by different underlying conditions share certain common features, but the trajectories of disease progression and survival outcomes differ.
Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models
Authors: Gertsenshteyn Inna , Epel Boris , Giurcanu Mihai , Barth Eugene , Lukens John , Hall Kayla , Martinez Jenipher Flores , Grana Mellissa , Maggio Matthew , Miller Richard C. , Sundramoorthy Subramanian V. , Krzykawska-Serda Martyna , Pearson Erik , Aydogan Bulent , Weichselbaum Ralph R. , Tormyshev Victor M. , Kotecha Mrignayani , Halpern Howard J. 
Published: October 2023

BackgroundClinical attempts to find benefit from specifically targeting and boosting resistant hypoxic tumor subvolumes have been promising but inconclusive. While a first preclinical murine tumor type showed significant improved control with hypoxic tumor boosts, a more thorough investigation of efficacy from boosting hypoxic subvolumes defined by electron paramagnetic resonance oxygen imaging (EPROI) is necessary. The present study confirms improved hypoxic tumor control results in three different tumor types using a clonogenic assay and explores potential confounding experimental conditions.Materials and methodsThree murine tumor models were used for multi-modal imaging and radiotherapy: MCa-4 mammary adenocarcinomas, SCC7 squamous cell carcinomas, and FSa fibrosarcomas. Registered T2-weighted MRI tumor boundaries, hypoxia defined by EPROI as pO2 ≤ 10 mmHg, and X-RAD 225Cx CT boost boundaries were obtained for all animals. 13 Gy boosts were directed to hypoxic or equal-integral-volume oxygenated tumor regions and monitored for regrowth. Kaplan–Meier survival analysis was used to assess local tumor control probability (LTCP). The Cox proportional hazards model was used to assess the hazard ratio of tumor progression of Hypoxic Boost vs. Oxygenated Boost for each tumor type controlling for experimental confounding variables such as EPROI radiofrequency, tumor volume, hypoxic fraction, and delay between imaging and radiation treatment.ResultsAn overall significant increase in LTCP from Hypoxia Boost vs. Oxygenated Boost treatments was observed in the full group of three tumor types (p &lt; 0.0001). The effects of tumor volume and hypoxic fraction on LTCP were dependent on tumor type. The delay between imaging and boost treatments did not have a significant effect on LTCP for all tumor types.ConclusionThis study confirms that EPROI locates resistant tumor hypoxic regions for radiation boost, increasing clonogenic LTCP, with potential enhanced therapeutic index in three tumor types. Preclinical absolute EPROI may provide correction for clinical hypoxia images using additional clinical physiologic MRI.
Prevalence and risk factors of work-related musculoskeletal disorders among emerging manufacturing workers in Beijing, China
Authors: Ding Xiaowen , Guan Ziyi , Liu Nan , Bi Mingli , Ji Fang , Wang Huining , Zhang Xueyan , Liu Baolong , Niu Dongsheng , Lan Tian , Xie Tingting , Li Jue , Yan Tenglong 
Published: October 2023

ObjectiveThe workers in emerging manufacturing are at decreased risk of traditional occupational diseases, while probably at increased risk of work-related musculoskeletal disorders (WMSDs). This study aimed to investigate the prevalence and risk factors of WMSDs among emerging manufacturing workers in Beijing.MethodsA total of 3,359 valid questionnaires were collected from 10 enterprises in the electronics, pharmaceutical, and motor manufacturing industries. The prevalence of WMSDs was assessed using the Nordic Musculoskeletal Questionnaire. The work posture load was evaluated through a questionnaire.ResultsThe results showed that the highest prevalence of WMSDs was observed in part of the neck (15.0%), followed by the lower back (12.5%), shoulders (11.2%), and upper back (7.1%). Female workers, workers aged older than 35 years, workers with a BMI of ≥28 kg/m2, longer working experience, never exercised had a higher prevalence of WMSDs. Logistic regression analysis showed that female workers, workers aged older than 35 years, with a middle school education and college degree, and workers who never exercised had a higher risk of WMSDs. In addition, workers who sat for long during work, worked hard with upper limbs or hands, worked in uncomfortable postures, and performed repetitive operations were positively related with the increased risk of WMSDs.ConclusionThese findings suggested that WMSDs were prevalent among emerging manufacturing workers in Beijing, China, while efforts should be made to reshape the risk factors associated with WMSDs, such as prolonged sitting, uncomfortable positions, and repetitive operations. Encouraging exercise and promoting ergonomic interventions probably be also benefit to induce the risk of WMSDs.