bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teledyne imaging sensors' recent contributions to astronomy, earth science, and planetary science
Authors: Beletic James W. , Auyeung John , Pan Jianmei , Corrales Liz , Dorn Meghan , Maitra Devraj , Farris Mark , Zandian Majid , Piquette Eric , Rangel Liz , Petersen Anders , Yulius Aristo , Bai Yibin , Bhargava Sid 
Published: December 2023

AbstractTeledyne Imaging Sensors (TIS) is the leading supplier of infrared focal plane arrays (FPAs) to astronomy and TIS plays a strong role in providing image sensors for Earth and Planetary Science. This article starts with a brief introduction to TIS' technologies and image sensor products. We then present some of TIS' deliveries to space missions and ground‐based telescopes. The space missions include ESA's Euclid Dark Universe mission and several NASA missions (James Webb Space Telescope, Roman Space Telescope, SPHEREx, EMIT). TIS continues to serve ground‐based astronomy by providing the H2RG and the world's largest high‐performance infrared astronomy FPA, the H4RG‐15, to several ground‐based observatories. Active programs will be described. Ongoing work includes NASA's NEO Surveyor asteroid surveillance mission, ESA's Ariel exo‐planet spectroscopy mission, and deliveries to the European Southern Observatory's Extremely Large Telescope.
Receptive language and receptive‐expressive discrepancy in minimally verbal autistic children and adolescents
Authors: Chen Yanru , Siles Brynn , Tager‐Flusberg Helen 
Published: December 2023

AbstractAmong the approximately one‐third of autistic individuals who experience considerable challenges in acquiring spoken language and are minimally verbal (MV), relatively little is known about the range of their receptive language abilities. This study included 1579 MV autistic children and adolescents between 5 and 18 years of age drawn from the National Database for Autism Research and the SFARI Base data repository. MV autistic children and adolescents demonstrated significantly lower receptive language compared to the norms on standardized language assessment and parent report measures. Moreover, their receptive language gap widened with age. Overall, our sample demonstrated significantly better receptive than expressive language. However, at the individual level, only about 25% of MV autistic children and adolescents demonstrated significantly better receptive language relative to their minimal expressive levels. Social skills explained a significant proportion of the variance in parent‐reported receptive language skills, while motor skills were the most significant predictor of greater receptive‐expressive discrepancy. Findings from this study revealed the heterogeneous language profiles in MV autistic children and adolescents, underscoring the importance of individualizing interventions to match their different communication strengths and needs and integrating multiple interconnected areas to optimize their overall development of language comprehension, socialization, and general motor skills.
One Pot Synthesis of Ammonium Rich Nickel Hexacyanoferrate as Stable Cathode Material for Ammonium‐Ion Batteries
Authors: Zhang Peng , Zhang Xiangguang , Liu Dahui , Xiang Ao , Lu Jun , Jiang Yan , Yang Ze , Hu Pei 
Published: December 2023

AbstractRechargeable aqueous batteries based on ammonium‐ion (NH4+) redox reactions shows great potential for large‐scale energy‐storage due to its plentiful supplies, environmental friendliness, intrinsic security, and sustainability. Prussian blue analogues (PBAs) are regarded to be one of the most promising electrode materials owning to high energy storage density, ease of synthesis, and excellent electrochemical performances. However, the synthesis of ammonium rich Prussian blue analogues is too complicated. Herein, a one pot synthesis of NH4+‐rich nickel hexacyanoferrate (NNiHCF) is developed and the NH4+ storage chemistry is investigated. NNiHCF cathode is coupled with an activated carbon (AC) anode and (NH4)2SO4 aqueous electrolyte to assemble ammonium‐ion batteries. The aqueous full cell demonstrates good electrochemical performance, such as 50.2 mAh g−1 at the current rate of 2 C, and 60 % capacity retention in 5000 cycles. Furthermore, the fundamental characteristics of the reversible redox reaction and the durable structure of NNiHCF are revealed by X‐ray diffraction (XRD) and electrochemical measurements. This work proposes a facile method for the synthesis of ammonium‐rich Prussian.
Reviewing the evolutive ACQ‐to‐AIE transformation of photosensitizers for phototheranostics
Authors: Zhu Wei , Huang Lin , Wu Chao , Liu Lingli , Li Haoxuan 
Published: December 2023

AbstractPhotodynamic therapy (PDT) represents an emerging noninvasive treatment technique for cancers and various nonmalignant diseases, including infections. During the process of PDT, the physical and chemical properties of photosensitizers (PSs) critically determine the effectiveness of PDT. Traditional PSs have made great progress in clinical applications. One of the challenges is that traditional PSs suffer from aggregation‐caused quenching (ACQ) due to their discotic structures. Recently, aggregation‐induced emission PSs (AIE‐PSs) with a twisted propeller‐shaped conformation have been widely concerned because of high reactive oxygen species (ROS) generation efficiency, strong fluorescence efficiency, and resistance to photobleaching. However, AIE‐PSs also have some disadvantages, such as short absorption wavelengths and insufficient molar absorption coefficient. When the advantages and disadvantages of AIE‐PSs and ACQ‐PSs are complementary, combining ACQ‐PSs and AIE‐PSs is a “win‐to‐win” strategy. As far as we know, the conversion of traditional representative ACQ‐PSs to AIE‐PSs for phototheranostics has not been reviewed. In the review, we summarize the recent progress on the ACQ‐to‐AIE transformation of PSs and the strategies to achieve desirable theranostic applications. The review would be helpful to design more efficient ACQ‐AIE‐PSs in the future and to accelerate the development and clinical application of PDT.
Precise ligand engineering of Ir(III)‐based photosensitizer with aggregation‐induced emission for image‐guided photodynamic therapy
Authors: Tong Jialin , Liu Ao , Huang Shanshan , Zhou Dan , Gao Ying , Wang Yan , Shan Guo‐Gang 
Published: December 2023

AbstractPhotodynamic therapy (PDT), which relies on the production of reactive oxygen species (ROS) induced by a photosensitizer to kill cancer cells, has become a non‐invasive approach to combat cancer. However, the conventional aggregation‐caused quenching effect, as well as the low ROS generation ability of photosensitizers, restrict their biological applications. In this work, a new Ir(III) complex with a dendritic ligand has been strategically designed and synthesized by ingenious modification of the ancillary ligand of a reported Ir(III) complex (Ir‐1). The extended π‐conjugation and multiple aromatic donor moieties endow the resulting complex Ir‐2 with obvious aggregation‐induced emission (AIE) activity and bathochromic emission. In in vitro experiments, importantly, Ir‐2 nanoparticles exhibit the excellent photoinduced ROS generation capabilities of O2•− and 1O2, as well as excellent biocompatibility and the lipid droplets (LDs) targeting feature. This study would provide useful guidance to design efficient Ir(III)‐based photosensitizers used in biological applications in the future.
Impact of ligand environment on optical, luminescence and thermometric behavior of A3(PO4)2:Sm3+ (A = Ca, Sr) phosphors
Authors: Singh Rajan , Manhas Mohit , Bedyal Ankush Kumar , Durani Fahim , Swart Hendrick C. , Kumar Vinay 
Published: December 2023

AbstractThe present study investigates the impact of the ligand environment on the luminescence and thermometric behavior of Sm3+ doped A3(PO4)2 (A = Sr, Ca) phosphors prepared by combustion synthesis. The structural and luminescent properties of Sm3+ ions in the phosphate lattices were investigated using powder X‐ray diffraction (PXRD) and photoluminescence (PL) techniques. PXRD results of the synthesized phosphors exhibit the expected phases that are in agreement with their respective standards. Fourier‐transform infrared (FTIR) spectroscopy confirms the presence of PO4 vibrational bands. Upon excitation with near ultraviolet light, the PL studies indicated that Sr3(PO4)2:Sm3+ phosphors exhibit a yellow light emission, whereas Ca3(PO4)2:Sm3+ phosphors exhibit an emission of orange light. The PL emission results are in accordance with the CIE coordinates, with the Sr3(PO4)2:Sm3+ phosphors showing coordinates of (0.56, 0.44), and the Ca3(PO4)2:Sm3+ phosphors displaying coordinates of (0.60, 0.40). Thermal analysis shows improved stability of Ca3(PO4)2:Sm3+ based on lower weight reduction in thermogravimetric analysis. The effect of temperature on the luminescence properties of the phosphor has been examined upon a 405 nm excitation. By using the fluorescence intensity ratio (FIR) method, the temperature responses of the emission ratios from the Sm3+: the 4F3/2 → 6H5/2 transition to the 4G5/2 → 6H7/2 and 4F3/2 → 6H5/2 transition to the 4G5/2 → 6H9/2 emissions are characterized. The Ca3(PO4)2:Sm3+ phosphors are more sensitive as compared with the Sr3(PO4)2:Sm3+ phosphors. The earlier research findings strongly indicate that these phosphors hold great promise as ideal candidates for applications in non‐invasive optical thermometry and solid‐state lighting devices.
Development and validation of a liquid chromatography–tandem mass spectrometry method for the quantification of the acetyl‐coenzyme A competitive p300/CBP catalytic inhibitor A‐485 in biological samples
Authors: Oertel Reinhard , Jaschke Nikolai , Lippert Annemarie , Renner Bertold 
Published: December 2023

AbstractThe small molecule A‐485 competitively inhibits the histone acetyltransferase domain of CBP (cyclic‐adenosine monophosphate response element‐binding protein)/p300. Apart from its antineoplastic activity, researchers are exploring its potential benefits in treating osteoporosis and its impact on energy metabolism. However, so far, only limited pharmacokinetic data are available, and the crucial determination of A‐485 concentration in various biological materials with small sample volumes remains unpublished. A rapid and sensitive LC–tandem mass spectrometry method has been developed and validated to quantify A‐485 in mouse serum and tissue. In this method, serum samples underwent precipitation with acetonitrile, while cell lysates were appropriately diluted. The determination of A‐485 utilized a reversed‐phase column with a mobile phase gradient, and detection was carried out in multiple reaction monitoring mode. The lower standard sample, with a concentration of 7.8 ng/mL, served as the lower limit of quantification, while the upper standard was established at 1000 ng/mL. A‐485 concentrations were assessed in both serum samples and the lysate of all examined tissues, revealing swift metabolic clearance. The analytical method outlined here is deemed appropriate for subsequent studies. The ability to measure the active ingredient in various compartments facilitates the determination of accurate pharmacokinetic parameters. In the event of human use of A‐485, the analysis method can be seamlessly transferred to human samples.
The nomogram for the prediction of overall survival after surgery in patients in early‐stage NSCLC based on SEER database and external validation cohort
Authors: Zhang Hao , Zeng Jingtong , Li Xianjie , Zhang Bo , Wang Hanqing , Tang Quanying , Zhang Yifan , Bao Shihao , Zu Lingling , Xu Xiaohong , Xu Song , Song Zuoqing 
Published: December 2023

AbstractBackground & AimsCurrently, there is a lack of effective tools for predicting the prognostic outcome of early‐stage lung cancer after surgery. We aim to create a nomogram model to help clinicians assess the risk of postoperative recurrence or metastasis.Materials and MethodsThis work obtained 16,459 NSCLC patients based on SEER database from 2010 to 2015. In addition, we also enrolled 385 NSCLC patients (2017/01‐2019/06) into external validation cohort at Tianjin Medical University General Hospital. Univariable as well as multivariable Cox regression was carried out for identifying factors independently predicting OS. In addition, we built a nomogram by incorporating the above prognostic factors for the prediction of OS.ResultsTumor size was positively correlated with the risk of poor differentiation. Advanced age, male and adenocarcinoma patients were factors independently predicting poor prognosis. The risk of white race is higher, followed by Black race, Asians and Indians, which is consistent with previous study. Chemotherapy is negatively related to prognostic outcome in patients of Stage IA NSCLC and positively related to that in those of Stage IB NSCLC. Lymph node dissection can reduce the postoperative mortality of patients. AUCs of the nomograms for 1, 2, and 3‐year OS was 0.705, 0.712, and 0.714 for training cohort, while those were 0.684, 0.688, and 0.688 for validation cohort.ConclusionsThe nomogram could be used as a tool to predict the postoperative prognosis of patients with Stage I non‐small cell lung cancer.
Long‐term outcomes of metastasis‐directed stereotactic body radiation therapy in metastatic nasopharyngeal carcinoma
Authors: Yang Jiangping , Liao Wenjun , Su Shitong , Zeng Ni , Zhang Shichuan , He Jinlan , Chen Nianyong 
Published: December 2023

AbstractBackgroundThe study aims to evaluate the outcomes of metastasis‐directed stereotactic body radiation therapy (SBRT) in metastatic nasopharyngeal carcinoma (mNPC).MethodsWe reviewed all SBRT conducted in patients with mNPC in our institution between 2013 and 2022. Systemic therapy was performed with chemotherapy with or without anti‐programmed death‐1 (PD‐1) therapy. Local treatment delivered with ablative purpose in stereotactic setting with dose/fraction ≥5 Gy was evaluated. Kaplan–Meier analyses were used to determine the rates of local control (LC), progression‐free survival (PFS), and overall survival (OS). Univariate and multivariate analyses were performed by Cox regression.ResultsA total of 54 patients with 76 metastatic sites receiving SBRT were analyzed. Median follow‐up was 49 months. The 3‐year LC, PFS, and OS rates were 89.1%, 29.4%, and 57.9%, respectively. Adding a PD‐1 inhibitor to SBRT tended to prolong median OS (50.1 vs. 32.2 months, p = 0.068). Patients receiving a biological effective dose (BED, α/β = 10) ≥ 80 Gy had a significantly longer median OS compared to those who received a lower dose (not reached vs. 29.5 months, p = 0.004). Patients with oligometastases (1–5 metastases) had a better median OS (not reached vs. 29.5 months, p < 0.001) and PFS (34.3 vs. 4.6 months, p < 0.001). Pretreatment EBV‐DNA and maintenance therapy were also significant predictors for OS.ConclusionsMetastatic NPC patients could benefit from metastases‐directed SBRT in combination with systemic therapy.
Design and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation
Authors: Durgun Mustafa , Akocak Suleyman , Lolak Nebih , Topal Fevzi , Koçyiğit Ümit Muhammet , Türkeş Cüneyt , Işık Mesut , Beydemir Şükrü 
Published: December 2023

AbstractThe present study focused on the synthesis and characterization of novel pyrazole carboxamide derivatives (SA1‐12). The inhibitory effect of the compounds on cholinesterases (ChEs; AChE and BChE) and carbonic anhydrases (hCAs; hCA I and hCA II) isoenzymes were screened as in vitro. These series compounds have been identified as potential inhibitors with a KI values in the range of 10.69±1.27–70.87±8.11 nM for hCA I, 20.01±3.48–56.63±6.41 nM for hCA II, 6.60±0.62‐14.15±1.09 nM for acetylcholinesterase (AChE) and 54.87±7.76–137.20 ±9.61 nM for butyrylcholinesterase (BChE). These compounds have a more effective inhibition effect when compared to the reference compounds. In addition, the potential binding positions of the compounds with high affinity for ChE and hCAs were demonstrated by in silico methods. The results of in silico and in vitro studies support each other. As a result of the present study, the compounds with high inhibitory activity for metabolic enzymes, such as ChE and hCA were designed. The compounds may be potential alternative agents used as selective ChE and hCA inhibitors in the treatment of Alzheimer′s disease and glaucoma.
Optimal decisions under price dynamics for Roth conversions
Authors: DiLellio James A. , Goldfeder Philip M. , McQuarrie Edward F. 
Published: December 2023

AbstractRetirees are faced with a variety of choices during their working and retirement years on how to best support their retirement lifestyle and estate planning goals. One of these choices is the option to convert a portion of their pretax savings from a tax‐deferred account (TDA) into a tax‐exempt Roth account. In this article, we quantify the Roth conversion payoff and when/how it depends on investment returns. We show that, while the use of taxable account assets may produce a larger payoff than early withdrawals from the Roth IRA, large unrealized taxable account gains and estate plans may change this calculus. Our work provides a recommendation on how current dividends or cash versus appreciated assets should be used to optimize Roth conversion payoffs, and informs FinTech companies and robo‐advisors on how to best support this important option for millions of current and future retirees.
Label‐Free Detection of Unbound Bilirubin and Nitrophenol Explosives in Water by a Mechanosynthesized Dual Functional Zinc Complex: Recognition of Picric Acid in Various Common Organic Media
Authors: Nair Ratish R. , Debnath Snehasish , Ghosh Riya , Bhattacharya Arnab , Raju M. , Chatterjee Pabitra B. 
Published: December 2023

AbstractHigh levels of unconjugated bilirubin (UB) in serum lead to asymptomatic and neonatal jaundice and brain dysfunctions. Herein, we have reported the detection of UB at as low as 1 μM in an aqueous alkaline medium using a Zn(II) complex. The specificity of the complex has been validated by the HPLC in the concentration window 6–90 μM, which is rare. The sensory response of the probe at physiological pH against nitro explosives developed it as an instant‐acting fluorosensor for picric acid (PA) and 2,4‐dinitrophenol (2,4‐DNP). Spectroscopic titration provided a binding constant of 4×105 M−1 with PA. The naked eye detection was found to be 15 μM. The solid‐state photoluminescent nature of the complex enabled it for PA sensing in the solid phase. Interestingly, the probe remained fluorescent in various volatile and non‐volatile organic solvents. As a result, it can also detect PA and 2,4‐DNP in a wide range of common organic media. NMR studies revealed the coordination of PA, 2,4‐DNP, and UB to the Zn(II) center of the probe, which is responsible for the observed quenching of the probe with the analytes.
Cu(I) Complexes Comprising tetrahedral Mo2E2 or Mo2PE units (E=P, As, Sb) as Chelating Ligands
Authors: Mondal Bijan , Scheer Manfred 
Published: December 2023

AbstractNovel isomorphous tetranuclear complexes, [(dppf)Cu(μ3,η2 : 2 : 2‐E2{CpMo(CO)2}2]BF4 [E=P (1), As (4), Sb (5), (dppf=1,1′‐bis‐(diphenylphosphino)‐ferrocene)] and [(dppf)Cu(μ3,η2 : 2 : 2‐PE{CpMo(CO)2}2]BF4 [E=As (2), Sb(3)] were synthesized from the reactions between [(dppf)Cu(MeCN)2][BF4] and tetrahedral molybdenum complexes containing unsubstituted homo‐ and hetero‐diatomic group‐15 elements [(μ,η2 : 2‐E2{CpMo(CO)2}2] [E=P (A), As (D), Sb (E)] and [(μ,η2 : 2‐PE{CpMo(CO)2}2] [E=As (B), Sb (C)], respectively. In all these products, the {Mo2E2} or {Mo2PE} moieties coordinate the Cu(I) center via a rare side‐on η2‐coordination mode. The X‐ray structure analyses of [(dppf)Cu(μ3,η2 : 2 : 1‐PSb{CpMo(CO)2}2][BF4] demonstrate, for the first time, the utilization of an η1‐coordination mode for the ligand complex C to coordinate to the Cu(I) center. All the products were characterized by X‐ray crystallography, NMR and IR spectroscopy, mass spectrometry and elemental analysis. Electrochemical studies also revealed the formation of 1–5, and, further, to understand the structure and bonding of the products, theoretical calculations using density functional theory (DFT) were conducted.
Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization
Authors: Semeno Volodymyr V. , Vasylchenko Vadym O. , Fesun Ihor M. , Ruzhylo Liudmyla Yu. , Kipriianov Mykhailo O. , Melnykov Kostiantyn P. , Skreminskyi Artem , Iminov Rustam , Mykhailiuk Pavel , Vashchenko Bohdan V. , Grygorenko Oleksandr O. 
Published: December 2023

AbstractElectrophilic double bond functionalization – intramolecular enolate alkylation sequence was used to obtain a series of bridged and fused bicyclo[m.n.k]alkane derivatives (i. e., bicyclo[4.1.1]octanes, bicyclo[2.2.1]heptanes, bicyclo[3.2.1]octanes, bicyclo[3.1.0]hexanes, and bicyclo[4.2.0]heptanes). The scope and limitations of the method were established, and applicability to the multigram synthesis of target bicyclic compounds was illustrated. Using the developed protocols, over 50 mono‐ and bifunctional building blocks relevant to medicinal chemistry were prepared. The synthesized compounds are promising isosteres of benzene and cycloalkane rings, which is confirmed by their physicochemical and structural characterization (pKa, LogP, and exit vector parameters (EVP)). “Rules of thumb” for the upcoming isosteric replacement studies were proposed.
How subjective ethical congruence facilitates leadership identification construction: A followership perspective
Authors: Fan Wei , Wang Zhenyuan , Wang Wen 
Published: December 2023

AbstractThis study examines subordinate subjective congruence resulting from personal ethical identity and perceived ethical leadership (PEL) on followership behaviors, including: obedience, proactive, and constructive resistance behaviors through identification with supervisors. Using polynomial regressions, results from self‐reported data of 208 employees in China supported that higher level of identification with supervisor occurs because of the following: (1) ethical congruence rather than ethical incongruence; (2) high‐high rather than low‐low congruence; (3) incongruence when personal ethical identity is lower than PEL rather than when personal ethical identity is higher than PEL. Moreover, such perceived ethical congruence facilitates followership obedience and proactive behaviors but not constructive resistance behavior via identification with supervisors. Relevant theoretical and practical implications are discussed.
A Label‐Free Deoxyribozyme Sensor for m6A Demethylase Activity Detection†
Authors: Wang Xiuyuan , Yu Shusheng , He Yuqiu , Wang Fuan , Liu Xiaoqing 
Published: December 2023

Comprehensive SummaryA label‐free deoxyribozyme (DNAzyme) biosensor for m6A demethylase activity detection is developed. When demethylase FTO (Fat mass and obesity‐associated protein), an important m6A demethylase of ALKBH demethylase family is present, the m6A group is specifically demethylated, and the cleavage activity of DNAzyme is restored. This allows the cleavage product that contains G‐quadruplex sequence to bind to thioflavin T (ThT) and generate fluorescence signals. The biosensor shows high specificity and sensitivity, and fast reaction speed. Our study demonstrates a new design of allosteric DNAzyme for sensing. This method represents the first label‐free nucleic acid biosensor for FTO assay, providing a feasible route towards inhibitors screening.