bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gluten‐free Nan‐e‐Fasaee: Formulation optimization on the basis of quinoa flour and inulin
Authors: Jamali Narjes , Sayadi Mehran , Nejati Roghayeh , Mohammadi Faezeh , Nematollahi Amene , Mollakhalili‐Meybodi Neda 
Published: November 2023

AbstractDiversification of gluten‐free (GF) bakery products is considerably important, as those who suffer from gluten intolerance should follow a GF diet their whole life. Regarding this study, it was aimed at optimizing the formulation of a quinoa‐based GF traditional bakery product, i.e. Nan‐e‐Fasaee using inulin as a bifunctional agent (both a prebiotic compound and a structure‐forming agent). Otherwise, its potential role as a fat and sugar replacer was also assessed. For this purpose, short (S)‐ and long (L)‐chain inulin were used as sugar and fat replacers, respectively, at 0%–50% w/w in quinoa flour (QF)‐based GF Nan‐e‐Fasaee and optimization was done based on rheological, textural, and sensory analysis. Results indicated that QF diet provided the batter with the dominance of elastic modulus and increased hardness (i.e. 5170.0 ± 22.50 g in the presence of QF compared to 1477.0 ± 20.81 g in wheat‐based ones). Inulin inclusion reduced the hardness, as the lowest was observed at S‐inulin substitution levels of 40% and 50% w/w, with values equal to 2422.0 ± 20.81 and 2431.0 ± 35.57 g, respectively (the most similar ones to control sample). The interference of S‐inulin with the non‐gelatinized starch structure is supposed to decrease the hardness. The highest score in texture was also perceived at F6 and F13, with values equal to 8.00 ± 0.10 and 7.97 ± 0.05, respectively. Using S‐ and L‐inulin in combination is found to improve the textural characteristics due to preventing the competitive role of sugar in water absorption in formulations containing L‐inulin. Regarding optimization of quinoa‐based GF Nan‐e‐Fasaee with reduced sugar and fat levels using inulin, it is found to be feasible.
Intelligent classification of cardiotocography based on a support vector machine and convolutional neural network: Multiscene research
Authors: Zhang Wen , Tang Zixiang , Shao Huikai , Sun Chao , He Xin , Zhang Jiahui , Wang Tiantian , Yang Xiaowei , Wang Yiran , Bin Yadi , Zhao Lanbo , Zhang Siyi , Liang Dongxin , Wang Jianliu , Zhong Dexing , Li Qiling 
Published: November 2023

AbstractObjectiveTo propose a computerized system utilizing multiscene analysis based on a support vector machine (SVM) and convolutional neural network (CNN) to assess cardiotocography (CTG) intelligently.MethodsWe retrospectively collected 2542 CTG records of singleton pregnancies delivered at the maternity ward of the First Affiliated Hospital of Xi'an Jiaotong University from October 10, 2020, to August 7, 2021. CTG records were divided into five categories (baseline, variability, acceleration, deceleration, and normality). Apart from the category of normality, the other four different categories of abnormal data correspond to four scenes. Each scene was divided into training and testing sets at 9:1 or 7:3. We used three computer algorithms (dynamic threshold, SVM, and CNN) to learn and optimize the system. Accuracy, sensitivity, and specificity were performed to evaluate performance.ResultsThe global accuracy, sensitivity, and specificity of the system were 93.88%, 93.06%, and 94.33%, respectively. In acceleration and deceleration scenes, when the convolution kernel was 3, the test data set reached the highest performance.ConclusionThe multiscene research model using SVM and CNN is a potential effective tool to assist obstetricians in classifying CTG intelligently.
Nomograms for predicting overall survival and cancer‐specific survival of endometrioid ovarian carcinoma: A retrospective cohort study from the SEER database
Authors: Wang Dan , Ran Xin , He You , Zhu Lvewen , Deng Youlin 
Published: November 2023

AbstractObjectiveEndometrioid ovarian cancer (EnOC) accounts for approximately 10%–15% of epithelial ovarian cancer cases. There are no effective tools for predicting the prognosis of EnOC in clinical work. The aim of this study was to construct and validate a nomogram to predict overall survival and cancer‐specific survival (CSS) in patients with EnOC.MethodsData regarding patients diagnosed with primary EnOC between 2004 and 2019 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. LASSO Cox regression and Cox regression analyses were performed to screen for prognostic factors, which were used to construct nomograms. In addition, we performed subgroup analyses of the prognostic value of chemotherapy and lymph node surgery.ResultsIn total, 3957 patients with primary EnOC were included in the analysis: 2770 in a training cohort and 1187 in a validation cohort. Age, stage, grade, lymph node surgery, and race were significantly and independently correlated with overall survival and CSS. Nomograms were constructed to predict 3‐ and 5‐year overall survival and CSS. Nomograms have good predictive ability and clinical practicability. Subgroup analysis showed that lymph node surgery improved the prognosis of patients with EnOC (P < 0.05) except for patients with grade III–IV and Stage I disease (overall survival P = 0.272, CSS P = 0.624). Chemotherapy did not improve survival time in most patients (P > 0.05) except for patients with grade I–II and Stage II–IV disease (overall survival P = 0.008, CSS P = 0.046).ConclusionWe constructed predictive nomograms and a risk classification system to evaluate overall survival and CSS in EnOC patients. For most patients with EnOC, chemotherapy did not improve the prognosis. In contrast to chemotherapy, lymph node surgery improved prognosis in most patients with EnOC.
Extrusion puffing as a pretreatment method to change the surface structure, physicochemical properties and in vitro protein digestibility of distillers dried grains with solubles
Authors: Liu Dongyun , Xie Yueqin , Deng Jianguo , Tang Jiayong , Zhao Hua , Liu Guangmang , Chen Xiaoling , Tian Gang , Cai Jingyi , Jia Gang 
Published: November 2023

AbstractBACKGROUNDDistillers dried grains with solubles (DDGS) are rich in nutrition, and they are potential protein feed raw material. However, the existence of cellulose, hemicellulose and lignin hinders animals' digestion and absorption of DDGS. Making full use of unconventional feed resources such as DDGS can alleviate the shortage of feed resources to a certain extent. This research investigated the effects of twin‐screw extrusion on the macromolecular composition, physical and chemical properties, surface structure and in vitro protein digestibility (IVPD) of DDGS.RESULTSThe findings showed that extrusion puffing significantly increased the protein solubility, bulk density, water holding capacity, and swelling capacity, while significantly decreased hemicellulose and crude protein content, particle size and zeta potential of DDGS. The structure damage of DDGS induced by the extrusion was characterized by scanning electron microscopy (SEM), Fourier‐transform infrared (FITR) spectroscopy and X‐ray diffraction (XRD) analysis. Interestingly, no random coil was observed in the analysis of the secondary structure, and extrusion promoted the transformation of α‐helix and β‐turn to β‐sheet, which led to significant increases in protein solubility and IVPD of DDGS (P < 0.05). Additionally, correlation analysis revealed that IVPD and PS had a positive relationship.CONCLUSIONExtrusion puffing was an ideal pretreatment method for DDGS modification to improve in vitro protein digestibility. © 2023 Society of Chemical Industry.
Tensile properties of flexible composites with knitted reinforcements from various yarn materials
Authors: Schwaiger Markus , Roeper (Röper) Florian , Wolfahrt Markus , Taesler Johannes , Schirmer Heiko , Salzmann Moritz , Feuchter Michael , Resch‐Fauster Katharina 
Published: November 2023

AbstractThe tensile behavior of a flexible epoxy resin reinforced with knitted reinforcements from various fiber materials was comprehensively studied in the wale and course direction. By measuring dry yarns, temperature‐treated yarns, dry knitted fabrics and flexible composites, the effect of the fiber material and the knitted fabric on the tensile properties was analyzed. The interlock knit structure strongly affected the deformation behavior of the flexible composites which differed significantly from the dry knitted fabrics. The deformation behavior of the flexible composites was monitored using digital image correlation which revealed the formation of cracks and high local strain differences in the course direction for all fiber materials. This was linked to fiber‐matrix debonding by scanning electron microscope observations. In the wale direction, the deformation of the knitted structure under tensile load led to plastic deformation of the matrix material. Overall, with yarns from recycled thermoplastic fibers, a higher maximum stress and strain at break was achieved compared to bio‐based fibers. However, irreversible damage occurred for all fiber materials at similar strain values.Highlights
Tensile tests on yarns, knitted fabrics and flexible composites.
Investigation of the effect of fiber material on mechanical properties.
High local strain differences in composites due to knitted structure.
Fiber‐matrix debonding in course direction.
Plastic deformation of the matrix material in the wale direction.
Cardiovascular adverse events in patients with hepatocellular carcinoma receiving vascular endothelial growth factor inhibitors
Authors: Yuan Fangzheng , Lenneman Carrie , Krone Ronald , Williams Grant R. , Outlaw Darryl , Katsnelson Michael , Lirette Stephen 
Published: November 2023

AbstractBackgroundVascular endothelial growth factor inhibitors, including tyrosine kinase inhibitors (TKIs) and anti‐angiogenics, are first‐line therapies for advanced and metastatic hepatocellular carcinoma. Although TKIs have a greater potential for off‐target adverse effects compared with bevacizumab (anti‐angiogenics), a direct comparison of the risk of cardiovascular adverse events between these two types of therapies has not been performed.ObjectiveTo compare the incidence of and characterize cardiovascular adverse events in patients with hepatocellular carcinoma receiving TKIs versus bevacizumab.MethodsThis cohort study included adult patients with hepatocellular carcinoma who received first‐line TKIs (sorafenib or lenvatinib) or bevacizumab at two academic medical centers and one community cancer center from September 2018 to August 2021. The primary outcome was risk of cardiovascular adverse events. Major secondary outcomes included the incidence of individual types of cardiovascular adverse events and risk factors associated with major adverse cardiovascular events (MACE).ResultsThe study included 221 patients (159 TKI patients; 62 bevacizumab patients). At a median follow‐up of 5 months, the probability of cardiovascular adverse events was not significantly different between the two groups (hazard ratio [HR]: 0.85; 95% confidence interval [95% CI]: 0.58–1.24; p = 0.390). The cumulative incidence of cardiovascular events was highest in patients receiving lenvatinib (sub‐distribution hazard ratio [SHR]: 1.53; 95% CI: 1.02–2.30) compared with those receiving sorafenib (reference) or bevacizumab (SHR: 1.05; 95% CI: 0.68–1.64) after adjustment for comorbidities, liver transplant status, and presence of portal vein thrombosis at baseline. Cardiovascular adverse events were observed in 151 (68%) patients, and MACE were observed in 27 (12%) patients. Risk factors associated with MACE were hypertension (SHR: 3.5; 95% CI: 0.9087–15.83; p = 0.086), prior history of MACE (SHR: 2.01; 95% CI: 0.83–4.87; p = 0.124), and tobacco use (SHR: 2.85; 95% CI: 0.90–8.97; p = 0.074).ConclusionsCardiovascular risk was not significantly different between TKIs and bevacizumab. Lenvatinib appears to have the highest risk of cardiovascular adverse events among these first‐line VEGF inhibitors.
Safeguarding strategies in athletes with intellectual disabilities: A narrative review
Authors: Raum George , Chowdhary Kuntal , Glotfelty‐Scheuering Olivia A. , Stratton Catherine S. M. , Tuakli‐Wosornu Yetsa A. 
Published: November 2023

AbstractCompared to their non‐disabled peers, athletes with disabilities are at an increased risk of interpersonal violence in sport. Athletes with intellectual disabilities specifically may face compounded risk due to impaired communication and social challenges. Despite the inherent risk of interpersonal violence in athletes with intellectual disabilities, there is a paucity of literature focused on safeguarding strategies in this population, and no global consensus prevention guidelines exist. The goal of this review was to synthesize the literature on interpersonal violence in athletes with intellectual disabilities and propose an evidence‐informed safeguarding framework. Future research and practice should emphasize tailored training on appropriate athlete‐protection strategies and ways to recognize and respond to suspicions of abuse in this population. Given the benefits of sports participation for persons with intellectual disabilities, implementation of fit‐for‐purpose safeguarding strategies would help address any elevated risk of interpersonal violence. Formal monitoring and evaluation of these initiatives can help minimize interpersonal violence.
Cumulative information generating function and generalized Gini functions
Authors: Capaldo Marco , Di Crescenzo Antonio , Meoli Alessandra 
Published: November 2023

AbstractWe introduce and study the cumulative information generating function, which provides a unifying mathematical tool suitable to deal with classical and fractional entropies based on the cumulative distribution function and on the survival function. Specifically, after establishing its main properties and some bounds, we show that it is a variability measure itself that extends the Gini mean semi-difference. We also provide (i) an extension of such a measure, based on distortion functions, and (ii) a weighted version based on a mixture distribution. Furthermore, we explore some connections with the reliability of k-out-of-n systems and with stress–strength models for multi-component systems. Also, we address the problem of extending the cumulative information generating function to higher dimensions.
Physical properties of copper oxide nano-composite incorporated PVP/chitosan blend matrix by casting method
Authors: Abdelrazek E. M. , Elzayat Asmaa M. , Elbana A. A. , Awad W. M. 
Published: November 2023

AbstractNanocomposite blend films were prepared by a simple casting method. Polyvinyl propylene (PVP) and chitosan (PVP/chitosan) were used as a based material. Different CuO nanoparticles concentrations were added to a specific blend film concentration of PVP/chitosan (80/20). The mechanism of the interaction between the blend and the nanoparticles was studied by different characterization techniques. The structure modification was confirmed by X-ray diffraction pattern due to the addition of the nanoparticles, in addition, the complexation and the miscibility between the nanoparticles and the blended composite was confirmed by UV–Vis spectroscopy and Fourier transform infrared spectroscopy is by the appearance of new peaks in the spectrum. The band gap computation and optical characteristics show that the addition of the nanoparticles decreases the crystallinity of the nanocomposites system. The findings show that the surface morphology checked by scanning electron microscopy shape and swelling rate behavior are affected by the integration of CuO nanoparticles into the polymer blend matrix. From all the results, this work has a great interest in wide bioapplications such as wound healing and food packing.
Calibration and validation of solar radiation-based equations to estimate crop evapotranspiration in a semi-arid climate
Authors: Nikolaou Georgios , Neocleous Damianos , Manes Antonio , Kitta Evangelini 
Published: November 2023

AbstractThe Abtew and Jensen-Haise solar radiation-based equations were used to estimate evapotranspiration, considering the limited climatic data in many locations. Both equations were proven to successfully predict the potential evapotranspiration (ETO) compared with the standard Penman–Monteith (PM) method in two Mediterranean countries. Calibration of the constant coefficient k of the Abtew equation showed substantial differences compared to recommended values (1.22 vs. 0.53), with the highest values observed during September (1.46). Validation of ETO measurements using calibrated Abtew equation against the PM method indicated a high correlation coefficient (r2 = 0.97, RMSE = 0.61). Further, evapotranspiration requirements, using the calibrated empirical equation, were calculated for olives (449 mm) and citrus (807 mm) showing a good agreement with recommended values for dry climate regions. Therefore, the tested equations could be safely used to predict frequencies and doses of irrigation in semi-arid climates, considering limited climatic data availability.
Die Geschichte der Psychosomatik in Österreich
Authors: Scheer Peter J. 
Published: November 2023

ZusammenfassungDer Medizin und ihrer Vorgängerin, der Religion, sind leib-seelische Zusammenhänge seit jeher bekannt. Die Erörterungen zu Diagnose und Therapie der Lepra in der hebräischen Bibel sind sowohl phänomenologisch, also auf das Leibliche sowie den Verlauf und die Heilung der Krankheit ausgerichtet, als auch auf die angenommene Verursachung der Seuche durch die „böse Zunge“ – das Gerücht. Heilungen durch den Geist durchziehen auch neutestamentliche Berichte. Der Glaube heilt aussichtslos Kranke. Ein Lepröser wird durch Jesu Wirken geheilt. Die Heilung durch das säkuläre Gespräch in der modernen Medizin ist eine jüdische Erfindung. Sie fand am Beginn des 20. Jahrhunderts in Wien statt. Der Arzt Sigmund Freud erfand die Psychoanalyse zuerst als Behandlung der Hysterie, jedoch wurde von ihm und seinen Kollegen auch eine Vielfalt an Krankheiten mit der neuen Methode behandelt. Die neuzeitliche, besonders die österreichische Geschichte der Psychosomatik wird vom Verfasser teils als „Zeitzeuge“ berichtet. Einst als „junges Talent“ 1977 am Kongress der österreichischen Gesellschaft für Kinderheilkunde mit wenig Wissen und viel Selbstbewusstsein als Referent einer juvenilen Obstipation aufgetreten, hat er bei Emigranten der 1. Blüte der Psychoanalyse lernen dürfen und deren Erinnerungen erfahren. Referierend ist Weglassen Pflicht. Jede Erinnerung ist eine Geschichte, die für den Moment konstruiert wird. So sind auch die subjektiven Erinnerungen in dieser Serie. Daher ist jede andere Erinnerung und jeder andere Bericht vielleicht ähnlich wahrhaftig. Hier ist der erste Teil der fünfteiligen Serie zur Geschichte der Psychosomatik in Österreich. Die vier Teile sind: 1. die (Wieder‑)Erfindung der leib-seelischen Zusammenhänge durch die Psychoanalyse im fin de siècle – Sándor von Ferenczi; 2. die stürmische Entwicklung in Wien zwischen den Weltkriegen – Minderwertigkeit der Organe als Prinzip – Alfred Adlers; 3. während des Zweiten Weltkriegs: Exil und das M. H. Göring-Institut; 4. die Entwicklung nach dem 2. Weltkrieg: Erwin Ringels psychosomatische Station, Hans Zimprich als Pionier der Kinderpsychosomatik; 5. der Beitrag der Grazer Kinderpsychosomatik mit der Einbeziehung der gesamten Kinder- und Jugendzeit ab dem Säuglingsalter.
The Implications of the COVID-19 Pandemic for the Construction of the Family Affluence Scale: Findings from 16 Countries
Authors: Boer Maartje , Moreno-Maldonado Concepción , Dierckens Maxim , Lenzi Michela , Currie Candace , Residori Caroline , Bosáková Lucia , Berchialla Paola , Eida Tamsyn , Stevens Gonneke 
Published: November 2023

AbstractThe Family Affluence Scale (FAS) is a widely used and validated instrument to measure adolescents’ socioeconomic status (SES). It is plausible that the COVID-19 pandemic and resulting social and economic changes have affected the capacity of the six-item FAS-III to measure adolescent SES, particularly the holiday and computer items. Using data from 247,503 adolescents from 16 European countries participating in the Health Behaviour in School-aged Children (HBSC) study before (2013/14 and 2017/18) and during (2021/22) the pandemic, the present study aims to fill this gap. Findings showed that although the internal consistency of the scale decreased during the pandemic, related to the functioning of the computer and especially the holiday item, it was still acceptable in all countries. Furthermore, measurement invariance analysis showed that during the pandemic the item thresholds of the computer and particularly the holiday item deviated from the thresholds of these items before the pandemic. However, all item factor loadings were comparable to the factor loadings before the pandemic. In addition, during the pandemic the computer and holiday item and their correlations with health-related outcomes were mostly still in the expected direction. Removing these items from the scale yielded comparable or decreased scale criterion validity as compared to the original FAS-III scale in most countries. These findings inform future research that although mean differences in family affluence levels before and during the pandemic should be interpreted with caution, it is a suitable tool to study (changes in) socioeconomic health inequalities among adolescents during the pandemic.
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
Authors: Zhang Zhengzheng , Xie Wenran , Gong Bojiang , Liang Xue , Yu Hongjia , Yu Yanwen , Dong Zhixiong , Shao Fanggui 
Published: November 2023

AbstractSmall GTPases regulate multiple important cellular behaviors and their activities are strictly controlled by a mass of regulators. The dysfunction or abnormal expression of small GTPases or their regulators was frequently observed in various cancers. Here, we analyzed the expression and prognostic correlation of several GTPases and related regulators based on the TCGA database and found that Ankyrin Repeat and PH Domain 1 (ARAP1), a GTPase activating protein (GAP), is reduced in lung adenocarcinoma tissues compared to normal tissues and displays a positive correlation with overall survival (OS) and progression-free survival (PFS) of patients with lung adenocarcinoma. qPCR and western blot verified that ARAP1 is frequently downregulated in lung adenocarcinoma tumor tissues and cancer cells, and its downregulation might be mediated by epigenetic modification. Moreover, metastatic assays showed that overexpression of ARAP1 significantly inhibits metastasis of lung adenocarcinoma in vitro and in vivo. We further demonstrated that Rho signaling inhibition, mediated by RhoGAP activity of ARAP1, majorly contributes to suppressing migration and invasion of lung adenocarcinoma cancer cells via inhibiting stress fibers formation. In summary, this study indicates that ARAP1 may serve as a potential prognostic predictor and a metastatic suppressor in lung adenocarcinoma via its RhoGAP activity.