bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of non-elastic taping on the kinematics of the lower extremities during overhead squat in subjects with dynamic knee valgus
Authors: Park Won-Young , Bae Dong-Yun , An Da-In , Jung Jong-Chul , Choi Go-Eun , Yun Hye-Lyeong , Shin Yong-Il , Kim Jun-Seok , Kim Soo-Yong 
Published: December 2023

BACKGROUD: The control of hip and ankle joint movement is important for patients with dynamic knee valgus (DKV), but few studies have used non-elastic taping (NET) to adjust alignment of the hip and ankle joints during overhead squat (OHS) simultaneously in patients with DKV. OBJECTIVE: We investigated changes in lower extremity joint kinematics and dynamic balance after the application of NET to the hip and ankle joints during OHS. METHODS: A total of 30 DKV patients participated in this study. We determined the kinematics of the hip, knee, and ankle joints, and scores on the lower quarter Y-balance test (YBT-LQ) during OHS under three conditions (non-taping, NET on hip and ankle, and sham taping). RESULTS: Hip internal rotation, knee valgus, and the ankle dorsiflexion angle were significantly lower with NET than with non- or sham taping. The hip flexion angle and scores on the YBT-LQ were significantly greater with NET than with non- or sham taping. CONCLUSIONS: The application of NET while performing a OHS is a useful method for correcting lower extremity alignment in patients with DKV, however, application of NET on the ankle should be considered.
Concept Mapping to Define Components for an Occupation-Based Intervention for Parkinson’s Disease and Anxiety
Authors: Lovegrove Christopher J. , Sturkenboom Ingrid H.W.M. , Marsden Jonathan , Bannigan Katrina 
Published: December 2023

Background: Anxiety, a common symptom of Parkinson’s disease (PD), results in reduced life quality, reduced participation in meaningful roles and daily activities, and increased health burden. There are no evidence-based interventions to reduce the impact of anxiety in PD on participation. Objective: This study aimed to identify the key components required for the co-production of an occupation- and community-based intervention for people with PD-related anxiety. Methods: A participatory mixed-methods research study was conducted using online Group Concept Mapping methodology that included five stages: brainstorming, idea synthesis, sorting activity, rating activity, and analysis. A cluster map, pattern match, and ‘go-zone’ charts were created through multivariate statistical analysis based on participants’ responses. The stages were guided by questions generated by the research team working with stakeholders. Results: Eighty-three people participated, with 64 taking part in more than one activity. Participants included people with PD ( n = 72), care partners ( n = 6), and occupational therapists ( n = 5). The final map contained 119 statements with eight clusters (stress value 0.252): exercise, lifestyle changes, self-help, coping, access to information, professional help, peers and groups, support from others. Significant agreement existed between the importance and feasibility rating activities ( r = –0.07). ‘Go-zone’ charts highlighted the priority statements for intervention development. Conclusions: This novel participatory study highlighted priority components that provide starting points for future development of an occupation- and community-based intervention for people with PD-related anxiety.
Emerging Antibody-Drug Conjugate Therapies and Targets for Metastatic Renal Cell Carcinoma
Authors: Gottlich Harrison C. , Nabavizadeh Reza , Dumbrava Mihai , Pessoa Rodrigo Rodrigues , Mahmoud Ahmed M. , Garg Ishita , Orme Jacob , Costello Brian A. , Cheville John , Lucien Fabrice 
Published: December 2023

Background: Approximately 30% of renal cell carcinoma (RCC) cases present with de novo metastatic disease, while 20% to 30% of those with localized disease will develop metastases following surgical resection. Various drug classes have been investigated to treat RCC, including cytokine-based therapies, small molecule Vascular Endothelial Growth Factor (VEGF) tyrosine kinase inhibitors (TKIs) and antibody-based therapies. Up to 58% of patients fail to respond to primary immune checkpoint inhibitor (ICI) therapy, and nearly all initial responders experience disease progression due to the development of secondary resistance. Consequently, novel treatment options are being investigated. Objective: Review the rapidly evolving ADC therapeutic landscape in metastatic RCC including recent trials, emerging ADCs targets, and future directions for ADCs in the treatment of advanced RCC. Methods: Literature review using the MEDLINE database on important trials and presentations from the American Society of Clinical Oncology (ASCO), and the European Society for Medical Oncology (ESMO) conferences. Key words used included “renal cell carcinoma,” “RCC,” “metastatic RCC,” “advanced RCC,” “antibody-based therapies,” “immunotherapy,” “clinical trials,” and “emerging drugs.” Specifically for review of ADCs in RCC, the following search string was used with additional review of bibliographies from retrieved papers: “((antibody drug conjugate) OR (antibody-dependent cellular cytotoxicity) OR (chimeric antigen receptor)) AND ((kidney cancer) OR (renal cell carcinoma))”. Results: Several promising targets including MMP14, EGFR, MCT4, CA9, MET, CDH13, B7-H3, and PSMA were identified with relevant preclinical and clinical studies reviewed. Conclusions: While ADCs therapeutics have not shown benefit to date for renal cell carcinoma, there are ample promising candidates and targets for future research.
Effect of Momordica cochinchinensis extract on locomotor function and brain antioxidant enzyme activity in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated zebrafish Parkinson’s disease model
Authors: Singsai Kanathip , Srisuwan Supawadee , Charoongchit Pimchanok , Singkhum Nopphakarn 
Published: December 2023

BACKGROUND: Gac fruit ( Momordica cochinchinensis) belongs to the Cucurbitaceae family. The red aril of Gac fruit contains high concentrations of carotenoids, including lycopene and beta-carotene. OBJECTIVE: This study aimed to investigate the effect of Gac fruit aril extract on locomotor activities in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced zebrafish model and measure antioxidant enzyme activities in the zebrafish brain. METHODS: This study used adult male zebrafish ( Danio rerio) as an animal model. MPTP was used as a toxin to induce movement dysfunction in zebrafish, while the standard drug selegiline acted as a monoamine oxidase-B inhibitor. Locomotion was recorded on day 7 after MPTP induction using a digital video tracking system, and parameters related to zebrafish swimming, including total distance, velocity, and immobility, were observed. The brain tissue of the zebrafish was collected for antioxidant enzyme activity analysis. RESULTS: The results showed that Gac fruit extract at doses of 200 and 400 mg/kg improved locomotor functions in MPTP-induced Parkinsonism in zebrafish. However, antioxidant enzyme activities, such as catalase and superoxide dismutase activities, in the zebrafish brain showed no significant differences among all groups. CONCLUSIONS: These findings provide insights into the further research of Gac fruit extract as a nutraceutical for preventing Parkinson’s disease.
Identification of calculated parameters of the Hardening Soil model based on laboratory soil tests
Authors: Nosenko Viktor , Nechyporenko Dmytro , Fadeev Oleksiy 
Published: December 2023

The modern soil model Hardening Soil, which is used in many software complexes intended for solving geotechnical problems, is considered. The model makes it possible to take into account changes in deformation parameters of soils depending on the level of applied stresses and to describe the deformation processes of cohesive soils under complex loading/unloading trajectories.
The paper also presents tables and graphs obtained during laboratory studies of semi-hard clay "Kyiv marl" in a triaxial system and an oedometer. Based on these data, the soil strength parameters с' and φ', as well as the stiffens modules , , were determined.
To correlate the results of numerical simulation with the real behavior of clay soil in the Plaxis software complex, using the SoilTest virtual laboratory, a test in a triaxial compression device was simulated and soil parameters were identified. This approach makes it possible to increase the accuracy and quality of calculation results.
During identification, the parameters that most affect it were analyzed, which made it possible to better understand which parameters and in which ranges to vary in order to achieve the desired result.
It was determined that the most sensitive parameters are the section modulus of rigidity and the coefficient of destruction Rf. Their percentage sensitivity is 65.9% and 32%, respectively.
By varying the c' and φ' characteristics during the tests in the virtual laboratory, the destruction of the sample was simulated in accordance with real soil studies. Therefore, it is very important to correctly determine these parameters, because this can lead to an underestimation or, on the contrary, an overestimation of the strength of the soil base.
PROBLEMS OF REGULATING ECO-POSITIVE CHANGES IN SMART CITY FORMATION PROCESSES
Authors: Fomenko Oksana , Chechelnitsky Sergey 
Published: December 2023

Architects, scientists of the Kharkiv National University of Urban Economy. O.M. Beketov conducts research focused on writing the terms of reference for the "Software package for modeling the city as a dynamic system". This development is devoted to the problem of improving SMART-oriented software and analytical tools based on working with large data arrays (BIG DATA) in architectural and urban planning management. The purpose of this toolkit is prognostics and monitoring of the architectural component of the city as a dynamic system. The relevance of its implementation lies in the optimization of the principles of functioning of the architectural component of the city with the calculation of its impact on the processes of functioning of other urban subsystems.
As a development and improvement of this direction, a method for determining the optimal speed and acceleration of positive transformations of the architectural component of cities, based on the indicator "Ecological footprint of architecture", which is currently being developed, is proposed. It is a method of developing step-by-step strategies for the development of the architectural component of cities. The main problem is to determine the optimal pace of social, environmental and economic changes in the processes of achieving a sustainable state of the city. Too rapid changes will inevitably lead to an aggravation of the socio-economic crisis. Slow change has a negative impact on the sustainability and ecology of the region. For this reason, in this article, the authors have developed a concept for the formation of an indicator that determines the vector, speed and acceleration of modernization of the architectural component of the city. As a factor limiting the rate of change to a socially acceptable level, the indicator of "Sustainable accessibility of vital goods for the population" was chosen.
СHARACTERISTIC PATTERNS OF UNDAMPED OSCILLATIONS EXITATION WITH ADAPTIVE PHASE ADJUSTMENT ANALYSIS IN LINEAR/NON-LINEAR VIBRATION SYSTEMS
Authors: Chovnyuk Yurii , Cherednichenko Petro , Kravchyuk Volodymyr , Ostapushchenko Olga , Kravchenko Igor 
Published: December 2023

The analysis of undamped oscillations with a discrete number of possible stable amplitudes excitation mechanism as a result of an external periodic force influence, nonlinear in the motion coordinate of the exciting (linear/non-linear) vibra-tion-oscillatory system is given.
Characteristic phenomenon regularities are studied on two general models basis: a) the pendulum is under the external periodic force inhomogeneous in the coordinate influence; b) oscillator under the incident wave influence. It is shown that the phe-nomenon’s mechanism is related to phase capture and adaptive phase adjustment, which provides the necessary energy contribution to the vibrational process in this vibrating system.
TRANSFORMATION OF BORROWED PHENOMENA: THE BUDDHIST FRESCO IN DUNGHUAN AND THE ARCHITECTURE OF THE MOSQUES OF SHAANXI PROVINCE IN CHINA
Authors: Kuśnierz-Krupa Dominika , Ivashko Oleksandr 
Published: December 2023

The purpose of the article is to analyze the phenomenon of borrowing without being limited by a specific style, and on the basis of this to argue at which hierarchical level the transformation took place: at the level of composition, form or decor.
The relevance of the research topic is determined by the need to analyze how local cultural and artistic traditions influenced the transformation of borrowed styles and what exactly the phenomenon of transformation consisted of, whether it was the same for several borrowed styles.
As a result of the study of wall paintings in different periods, it was established that, according to the figurative concept of Dunhuang, the transformation was as follows:
– a departure from the original Indian frescoes by complicating the compositions in the direction of three-dimensionality and polymorphism, diversifying polychromy, anatomical perfection, detailing and giving the image a national color through portrait images of founders in Chinese clothes, scenes from their lives, landscape images;
– therefore, in the Dunhuang frescoes, the transformation was focused on the planar images of the fresco (the role of ritual sculpture in the Dunhuang sanctuaries was much smaller).
Despite the fact that Islam never competed with Buddhism, Taoism and Confucianism in terms of the number of believers in China, the rulers were friendly towards the construction of mosques. However, they are clearly dominated by Chinese traditions:
– there are much more courtyards than in traditional mosques, and they are landscaped according to Chinese landscape design and have ponds with fish (this is a purely Chinese tradition);
– the appearance of the pavilions and gates is purely Chinese: pavilions with a traditional Chinese silhouette, curved roofs with tiled roofs, complex multi-level eaves, open galleries on pillars, the use of traditional Chinese building materials (stone, brick, wood, tiles), bright polychromy, small detailing.
So, in the case of mosques as well, Chinese culture radically changed their appearance, giving them maximum similarity with the temples of traditional religions.
Thus, the transformation took place equally at all levels – planning, landscape design, three-dimensional form, plane with wall paintings and carvings.
Later, this style manifested itself in the transformation of European Art Nouveau, which was also superimposed on local traditions.
Transtorno mental e comportamental no estado do Pará: Variações da mortalidade e morbidade de 2017 a 2022
Authors: Bezerra Ana Carolina do Nascimento , Moura Darlena Lemos de , Pereira Kele Suane , Takeda Karina Faine Freitas 
Published: December 2023

As variações entre mortalidade e morbidade relacionadas a transtornos mentais e comportamentais refletem uma complexa interação entre fatores individuais, sociais e de saúde. Diante disso, este estudo objetiva determinar o quantitativo de internações e a taxa mortalidade causadas por transtornos mentais e comportamentais no estado do Pará entre os anos de 2017 e 2022. Para alcançar esse objetivo, foi realizado um estudo de coorte retrospetivo com dados do DATASUS. Amostra compôs todos os casos de transtorno emocional e comportamental, notificados no DATASUS e ocorridos no Estado do Pará no período de 2017 a 2022, sendo a população restringida aos casos de internação e óbito ocorridos no mesmo período. Os resultados demonstram um aumento gradual e constante no número de internações ao longo do tempo. Constatou-se também que 52% das internações ocorreram entre pacientes do sexo masculino, na faixa etária de 20 a 29 anos (28%), autodeclarados pardos (79%). No que se refere a mortalidade, em 2017, a taxa foi de 6%, indicando um baixo índice de mortalidade relacionada aos transtornos mentais e comportamentais no estado. No entanto, houve um aumento acentuado em 2018, atingindo 28%. Diante dos resultados encontrados, é necessário fortalecer as políticas públicas de saúde mental no estado do Pará, com ênfase na prevenção, promoção da saúde mental, acesso aos serviços especializados, capacitação dos profissionais de saúde e conscientização da população sobre a importância do cuidado com a saúde mental.
Tuberculose extrapulmonar com envolvimento renal e intestinal: Um desafio no diagnóstico precoce
Authors: Araújo Felipe Gabriel Andrade de , Saotome Lyu , Pierini Jéssica Louise de Godoi , Ruivo Gilson Fernandes 
Published: December 2023

A tuberculose extrapulmonar é uma manifestação da doença pulmonar que afeta outros órgãos e sistemas além dos pulmões. Sua incidência tem aumentado, principalmente em pacientes com imunossupressão. O diagnóstico e tratamento dessa forma da doença são desafios clínicos devido à diversidade de órgãos afetados. Os sintomas variam de acordo com o local afetado e o diagnóstico preciso requer uma abordagem multidisciplinar. O Brasil possui alta carga de tuberculose e a forma extrapulmonar corresponde a cerca de 20% dos casos notificados. Este estudo tem como propósito apresentar um relato de caso recente de tuberculose extrapulmonar com acometimento renal e intestinal, analisando os indícios e sintomas manifestados pela paciente, as abordagens diagnósticas empregadas e o tratamento instituído com base nas evidências científicas mais atualizadas. Utilizou-se uma metodologia de relato de caso clínico com características qualitativas descritivas, realizado no Hospital localizado no município de Taubaté/SP. A paciente recebeu o tratamento adequado e obteve uma evolução clínico-laboratorial satisfatória, resultando em uma recuperação funcional. Atualmente, a paciente continua em acompanhamento no Hospital Municipal Universitário de Taubaté, sob os cuidados da equipe de Nefrologia e Hepatologia.
Long-range prediction of the tropical cyclone frequency landfalling in China using thermocline temperature anomalies at different longitudes
Authors: Liu Chunlei , Zheng Rong , Jin Liang , Bao Ruijuan , Cao Ning , Liao Xiaoqing , Xue Yufeng , Chen Hailiang , Yang Ke , Su Qianye 
Published: December 2023

The landfalls of the tropical cyclone (TC) along the coast of China have caused huge economic damages. There are approximately nine TC landfalls in China every year. It will be beneficial if the landfall frequency can be predicted in advance. Inspired by the study of Sparks and Toumi (Commun Earth Environ, 30-1-2020), six datasets, including four ocean reanalyses and two object analyses from 1993 to 2019, are employed to study the consistency in the relationship between the thermocline temperature anomalies at different longitudes and the frequency of TC landfalls along the coastal areas of China (South China, East China, and the whole of China). The thermocline temperature anomalies at different longitudes are tested in order to confirm our hypothesis that the eastward and westward transports of ocean heat from the warm pool are the causes of the significant correlations. The results show some significant correlations at various longitudes, and the temperature anomalies can predict the TC landfall frequency for several months or longer. Further study also shows the close relationship between the ocean heat transport and the sea surface temperature anomalies at the genesis locations of TC landfalls. The locations of the western Pacific subtropical high (WPSH) during high-frequency TC landfall years also show favorable spatial patterns to the TC landfall in South China and East China, respectively. In years with a high TC frequency in South China, the westward displacement of the WPSH ridge steers TC toward South China, while during high-frequency TC landfall years in East China, WPSH is located further north, and the westward extension of the ridge is in close proximity to the East China Sea.
Experimental optimization of the Nafion® ionomer content in the catalyst layer for polymer electrolyte membrane water electrolysis at high temperatures
Authors: Li Hua , Huang Senrui , Guan Chao , Wang Huixuan , Nakajima Hironori , Ito Kohei , Wang Yulin 
Published: December 2023

The polymer electrolyte membrane water electrolysis (PEMWE) performance is closely related to the Nafion® ionomer content in catalyst layers (CLs). This study experimentally investigates the impact of anode and cathode Nafion® ionomer contents on the PEMWE performance at high temperatures. The Nafion® ionomer content is 5–30 wt% on both anode and cathode sides, while the temperature and operating pressure change from 80°C to 120°C and 0.1 MPa to 0.3 MPa, respectively. Experimental results reveal that elevated temperature and operating pressure can remarkably promote the performance of PEMWE with a reasonable Nafion® ionomer content and without dehydrating the membrane at 120°C and 0.3 MPa. However, the PEMWE performance deteriorates as the Nafion® ionomer content is too low. The anode Nafion® ionomer content has a relatively great impact on ohmic resistance, concentration, and activation overpotential, especially the concentration overpotential. Nevertheless, the cathode Nafion® ionomer content only affects the ohmic resistance. Finally, under the operating conditions of 120°C and 0.3 MPa, employing a Nafion ionomer content of 10 wt% in the anode–cathode sides minimizes the electrolysis voltage to 2.18 V at 18 A/cm2.
Strengthening deep-learning models for intracranial hemorrhage detection: strongly annotated computed tomography images and model ensembles
Authors: Kang Dong-Wan , Park Gi-Hun , Ryu Wi-Sun , Schellingerhout Dawid , Kim Museong , Kim Yong Soo , Park Chan-Young , Lee Keon-Joo , Han Moon-Ku , Jeong Han-Gil , Kim Dong-Eog 
Published: December 2023

Background and purposeMultiple attempts at intracranial hemorrhage (ICH) detection using deep-learning techniques have been plagued by clinical failures. We aimed to compare the performance of a deep-learning algorithm for ICH detection trained on strongly and weakly annotated datasets, and to assess whether a weighted ensemble model that integrates separate models trained using datasets with different ICH improves performance.MethodsWe used brain CT scans from the Radiological Society of North America (27,861 CT scans, 3,528 ICHs) and AI-Hub (53,045 CT scans, 7,013 ICHs) for training. DenseNet121, InceptionResNetV2, MobileNetV2, and VGG19 were trained on strongly and weakly annotated datasets and compared using independent external test datasets. We then developed a weighted ensemble model combining separate models trained on all ICH, subdural hemorrhage (SDH), subarachnoid hemorrhage (SAH), and small-lesion ICH cases. The final weighted ensemble model was compared to four well-known deep-learning models. After external testing, six neurologists reviewed 91 ICH cases difficult for AI and humans.ResultsInceptionResNetV2, MobileNetV2, and VGG19 models outperformed when trained on strongly annotated datasets. A weighted ensemble model combining models trained on SDH, SAH, and small-lesion ICH had a higher AUC, compared with a model trained on all ICH cases only. This model outperformed four deep-learning models (AUC [95% C.I.]: Ensemble model, 0.953[0.938–0.965]; InceptionResNetV2, 0.852[0.828–0.873]; DenseNet121, 0.875[0.852–0.895]; VGG19, 0.796[0.770–0.821]; MobileNetV2, 0.650[0.620–0.680]; p &lt; 0.0001). In addition, the case review showed that a better understanding and management of difficult cases may facilitate clinical use of ICH detection algorithms.ConclusionWe propose a weighted ensemble model for ICH detection, trained on large-scale, strongly annotated CT scans, as no model can capture all aspects of complex tasks.