bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agent-Based versus Data-Streamed Big-Data Parallelization in Computational Geometry
Authors: Fukuda Munehiro , Potturi Anirudh , Helzerman Joshua 
Published: October 2023

Abstract

While some spatial analytics in GIS are well-supported by combinations of data-streaming tools and machine-learning algorithms, (e.g., Spark and KNN on a geographic map), the others are tightly coupled with computational geometry. They handle multi-dimensional or graph structures that should be better maintained in distributed memory for the purpose of dynamic spatial analysis and repetitive geometric queries. We expect that dispatching agents as active data analyzers into datasets would work smoother than disassembling and conveying datasets into passive data-streaming tools. This research compared agent-based and data-streaming big-data parallelization in computational geometry. We parallelized the closest pair of points, the convex hull, the Euclidean shortest path, the point location, and the range search problems, using our MASS (multi-agent spatial simulation) library, MapReduce, and Spark. MASS performed best in three of the programs, which demonstrated agents’ strength in spatial analysis over many data points and repetitive geometric queries with deep tree traverses.
In silico and In vitro Antibacterial Activity of Essential oil of Eucalyptus globulus Labill
Authors: Salaria Deeksha , Rolta Rajan , Prakash Ajay , Fadare Olatomide A. , Jachak Sanjay , Medhi Bikash 
Published: October 2023

Abstract
Eucalyptus globulus Labill. Traditionally used as disinfectant, fumigant, insect repellent, it is also used to cure asthma, bronchitis, arthritis, boils etc. The current research is focused on to study the in vitro and in silico antibacterial activity of Eucalyptus globulus essential oil. Essential oil of Eucalyptus globulus was extracted by hydro-distillation method and characterized by GC-MS. In vitro antibacterial activity was done by using agar well diffusion and broth microdillution method. Further the antibacterial activity was predicted in silico by using Autodock vina. Essential oil extraction yield of Eucalyptus globulus leaves was found to be 2.13 ± 0.115%. Total seventeen mono- and sesqui-terpenoids were identified in essential oil, of which eucalyptol (60.327), D-limonene (6.964), terpinyl-acetate (3.564) and gamma gurjunene (2.505%) were the major constituents. Essential oil of Eucalyptus globulus showed significant antibacterial activity against Clinical strains of Escherichia coli, Staphylococcus aureus and Methicillin-resistant Staphylococcus with minimum inhibitory concentration values of 0.125, 0.125 and 0.3125% respectively. In molecular docking study, γ-gurjunine showed good binding energy with penicillin binding protein (3VSL) and MD simulation confirmed the stability of protein ligand complex. Essential oil of Eucalyptus globulus has good antibacterial activity against clinical strains of grams positive and grams negative bacteria. Essential oil of Eucalyptus globulus can be used as antibacterial agent with addition of in vitro and in vivo toxicity.
MDFBEAM: Multi-Dimensional Fuzzy-Based Emotion Analysis Framework for Micro-Blog News Sub-Events
Authors: Vijayakumar Angel Petricia , V Mary Anita Rajam 
Published: October 2023

Abstract
Social media has replaced traditional journalism, such as television and newspapers, by a large proportion. Social media data presents an incredible opportunity for governments and organizations to understand the public's response to a news event, which is critical for government organizations to make informed decisions. News events are made up of a series of related sub-events. These sub-events determine the flow and dynamics of the entire news event. Hence, monitoring the public's response to each sub-event is crucial. This work proposes a framework to classify microblogs that discuss news sub-events into eight dimensions of emotion: Happy, Sad, Fear, Anger, Cynical, Neutral, Positive and Negative. This work introduces a cynical emotion that attempts to catch skepticism and sarcastic emotions, which are highly common in news-based events. Not limited to news events and microblogs, this framework can be utilized on any public response monitoring system without much changes. The proposed framework employs a bi-layered composite fuzzy mechanism. The emotions are represented as fuzzy sets. The fuzzy membership score of a microblog towards each fuzzy set is generated by integrating neural-network-based pre-trained word vector similarity, thesaurus-based similarity, and linguistic hedge information for each word. Fuzzy inference is then employed to identify the predominant emotion expressed in a microblog. This work is compared against state-of-the-art BERT models and demonstrates a remarkably high level of precision.
Oral formulation of 5-aminosalicylic acid-Hemoglobin bio-adhesive nanoparticles enhance therapeutic efficiency in Ulcerative Colitis mice: A preclinical evaluation
Authors: Vaezi Zahra , Ghavami Shaghayegh Baradaran , Farmani Maryam , Mahdavian Reza , Aghdaei Hamid Asadzadeh , Naderi-manesh Hossein 
Published: October 2023

Abstract
The oral formulation design for colon-specific drug delivery brings some therapeutic benefits in the ulcerative colitis treatment. We recently reported the specific delivery of hemoglobin nanoparticles-conjugating 5-aminosalicylic acid (5-ASA- HbNPs) to the inflamed site. In the current study, the in vivo evaluation of 5-ASA from its bio-adhesive nanoparticles shows the greatly long residence time of 5-ASA and complete support of the colon as compared with free 5-ASA due to the suitable mucoadhesive property to traverse the mucus layer and accumulate within the mucosa is a vital process. Furthermore, the UC model mice exhibited notably reduced indexes of disease activity; along with decreased ratios of colon weight/length in the group treated with 5-ASA-HbNPs. This group received a one-thousandth of the standard dosage of 5-ASA amount (50 μg/kg). While, a similar result was observed for a considerable quantity of free 5-ASA (50 mg/kg), confirming the therapeutic efficacy of this formulation in vivo. Furthermore, microscopic images of histological sections of the extracted colons demonstrated that the 5-ASA-HbNPs and 5-ASA groups displayed instances of inflammatory damage within the colon. However, in comparison to the control group, the extent of this damage was relatively moderate, suggesting 5-ASA-HbNPs improved therapeutic efficacy with the lower dosage form.
Urinary Biomarkers NGAL and Beta-2 Microglobulin for Detection of Diabetic Nephropathy in Type 1 Diabetes Mellitus
Authors: Sachan Nimisha , Dabas Aashima , Mantan Mukta , Dabla Pradeep Kumar 
Published: October 2023

Abstract
Objectives: Urinary neutrophil gelatinase-associated lipocalin (NGAL) and beta-2 microglobulin(β2M) have been evaluated as markers of tubular damage in type 2 diabetes mellitus. There is limited data on their performance to screen nephropathy in type 1 diabetes mellitus (T1DM).
Methods: This case-control study enrolled 40 children with T1DM and 40 age-matched controls age 2-18 years. Subjects with coexisting renal disorder and syndromic diabetes mellitus were excluded. Fasting plasma glucose, glycated hemoglobin (HbA1c), and renal function were measured. Urinary levels of urine albumin-creatinine ratio (ACR), neutrophil gelatinase-associated lipocalin (NGAL) and beta-2 microglobulin (β2M) were measured for an associated with disease duration, glycemic control and microalbuminuria. Correlation (r) was measured for statistical association between biochemical markers and area-under-curve (AUC) calculated to predict nephropathy.
Results: The median (IQR) age of cases and controls was 10.6(8,14.2) and 10.7 (8.4,13.7) years, respectively, disease duration 4 (3,6.8) years and HbA1c 10.9(9.,13.1)% in cases. Microalbuminuria was seen in 14(35%) but none had macroalbuminuria.The urinary ACR and NGAL were significantly higher in cases than controls [19.38 (10.27,35.26) and 6.49 (3.10,11.65) µg/mg; p<0.001] and [352.21(191.49,572.45) and 190.54 (125.91,322.83) ng/mg; p=0.006], respectively, unlike β2M [1.7 (0.43,6.02) and 2.12 (1.05,4.47) µg/mg; p=0.637]. Children with higher HbA1C (>10%) had higher urinary ACR, NGAL and β2M levels than those with HbA1C<10%. Urinary ACR showed positive correlation with NGAL/creatinine (r= 0.38, p value=0.019) and β2M/ creatinine (r=0.48, p value= 0.004) in cases. The AUC was 0.57 (95% CI 0.36,0.78); p value= 0.48 for NGAL/creatinine, and 0.62 (95%CI 0.43,0.81); p value=0.21 for β2M /creatinine to predict microalbuminuria (ACR >30mg/g).
Conclusion: Urinary biomarkers NGAL and β2M showed a good correlation with ACR suggesting their role in screening of diabetic tubulopathy before overt glomerular damage in T1DM.
Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA- pyroptosis pathway in cancer
Authors: Yang Yuxuan , Yang Jia , Zhu Nan , Qiu Haosen , Feng Wenxiang , Chen Ying , Chen Xinhua , Chen Yuehong , Zheng Wenbo , Liang Min , Lin Tian , Yu Jiang , Guo Zhaoze 
Published: October 2023

Abstract
In recent years, immunotherapy has emerged as a promising strategy for treating solid tumors, although its efficacy remains limited to a subset of patients. Transforming non-responsive "cold" tumor types into immuno-responsive "hot" ones is critical to enhance the efficacy of immune-based cancer treatments. Pyroptosis, a programmed cell death mechanism, not only effectively eliminates tumor cells but also triggers a potent inflammatory response to initiate anti-tumor immune activities. This sheds light on the potential of pyroptosis to sensitize tumors to immune therapy. Hence, it is urgent to explore and develop novel treatments (e.g., nanomedicines) which are capable of inducing pyroptosis. In this study, we constructed tumor-targeting nanoparticles (CS-HAP@ATO NPs) by loading atorvastatin (ATO) onto chondroitin sulfate (CS) modified hydroxyapatite (HAP) nanoparticles (CS-HAP). CS was strategically employed to target tumor cells, while HAP exhibited the capacity to release calcium ions (Ca2+) in response to the tumor microenvironment. Moreover, ATO disrupted the mitochondrial function was disrupted, leading to intracellular energy depletion and consequential changes in mitochondrial membrane permeability, following by the influx of Ca2+ into the cytoplasm and mitochondria. CS and HAP synergetically augmented mitochondrial calcium overload, inciting the production of substantial amount of reactive oxygen species (ROS) and the subsequent liberation of mitochondrial DNA (mitoDNA). This intricate activation process promoted the assembly of inflammasomes, most notably the NLRP3 inflammasome, followed by triggering caspase-1 activation. The activated caspase-1 was able to induce gasderminD (GSDMD) protein cleavage and present the GSDM-N domain, which interacted with membrane phospholipids on the cell membrane. Then, the cell membrane permeability was raised, cellular swelling was observed, and abundant cell contents and inflammatory mediators were released. Ultimately, this orchestrated sequence of events served to enhance the anti-tumor immunoresponse within the organism.
IoT Integration in Telemedicine: Investigating the Role of Internet of Things Devices in Facilitating Remote Patient Monitoring and Data Transmission
Authors: Auwal Aminu Muhammad 
Published: October 2023

Abstract
Introduction:
The integration of Internet of Things (IoT) technology with telemedicine has ushered in a groundbreaking era for healthcare, allowing for remote monitoring and data transmission of patients. This research paper aims to explore the complex relationship between IoT devices and telemedicine, examining their combined potential to improve patient care and transform healthcare workflows.
Method:
To gain a deeper understanding of the impact of IoT-powered telemedicine, a qualitative study was conducted to explore the experiences and perspectives of both healthcare practitioners and patients. Using in-depth interviews and content analysis, we examined the integration of IoT devices, such as wearables and remote sensors, into telemedicine platforms. This allowed us to uncover real-time health data collection and transmission from patients' homes to medical professionals.
Result:
This study's analysis of the benefits, challenges, and user satisfaction indicates that IoT-powered remote patient monitoring significantly enhances patient care by facilitating timely interventions and reducing hospital admissions, ultimately leading to improved healthcare outcomes and highlighting the effectiveness of IoT-powered remote patient monitoring in relation to healthcare outcomes.
Furthermore, we analyze the complex technical factors that influence the effective deployment of IoT devices in telehealth settings. The integration of telemedicine with IoT technology is a complex process that requires careful consideration of several factors, including data security, interoperability, and data analytics. These factors play a crucial role in ensuring the effective and secure exchange of health information between different systems. The insights gained from this research can help to inform the development of best practices for telemedicine, ultimately improving patient care and outcomes. The findings also have implications for healthcare providers, technology developers, and policymakers who seek to leverage IoT-integrated telehealth solutions in their work.
Rodents consuming the same toxic diet harbor a unique taxonomic and functional core microbiome
Authors: Stapleton Tess E. , Lindsey LeAnn M. , Sundar Hari , Dearing M. Denise 
Published: October 2023

Abstract
Gut microbiota are intrinsic to an herbivorous lifestyle, but very little is known about how plant secondary compounds (PSCs), which are often toxic, influence these symbiotic partners. Using 16S rRNA gene and shotgun metagenomic sequencing, we investigated the possibility of a unique taxonomic and functional core microbiome in populations of two species of woodrats (Neotoma lepida and bryanti) that have independently converged to feed on the same toxic diet (creosote bush; Larrea tridentata). In each gut region (foregut, cecum, and hindgut) sampled, we found a distinct taxonomic core set of microbes in the populations feeding on creosote that were not designated as core members in noncreosote-feeding populations. The core members in creosote feeders were significantly enriched and occurred more frequently than predicted by chance, suggesting that they may benefit the host. Some of the functions identified within the functional core include the metabolism of aromatic rings and thus may be involved in the degradation of PSCs. Overall, our results characterize the functional profiles of the gut microbiota in a wild herbivore and identify key taxa that may aid herbivores in subsisting on their toxic diet.
Chorizo sausage with shiitake mushrooms (Lentinula edodes) as a fat substitute: quality evaluation
Authors: Rincón Soledad Edicson Mauricio , Arredondo Nontién Mónica Alejandra , Castro Jose Wilson , Barrios Dursun , Vásquez Mejía Sandra Milena 
Published: October 2023

Traditional meat products are made with large amounts of saturated fat and binders such as starch, which increase calories and move away from current consumer trends that seek low-fat products with natural ingredients. Shiitake mushroom has beneficial health properties and it can be used as a fat substitute in processed meat products. We aimed to identify the effects of incorporating shiitake powder into chorizo sausages as a fat substitute.
Shiitake powder was characterized and five formulations of chorizo sausage were developed: control and four experimental samples with 30, 40, 50 and 100% fat substitution (the latter included 50% of shiitake powder and 50% of olive oil).
The experimental sausage showed a greater moisture, lower lipid content, and less cooking loss. The samples with shiitake powder were darker and less red than the control. Texture parameters were not affected by substituting 40% of fat with shiitake powder. The treatment with 40% fat substitution had a greater insoluble fiber content and a lower aerobic mesophile count (CFU/g) than the control. No significant differences were found in the fatty acids profile. The samples with shiitake powder had a moderate level of sensory acceptance which might be associated with the consumers’ lack of familiarity with shiitake.
Consumers may accept comminuted sausages in which a maximum of 40% of fat is substituted with shiitake powder. Such products have an adequate nutritional composition, as well as acceptable physicochemical, technological, and microbiological properties.
Vulnerability assessment of water supply infrastructures through multiple indicator methodology
Authors: Borzì Iolanda 
Published: October 2023

Abstract

Water supply infrastructures are essential to ensure the well-being of communities and to support social and economic growth and must be protected from damage in the context of future threats related to the environmental consequences of climate change. Those consequences include natural disasters, i.e., landslides, which can cause destruction of water infrastructure, causing distress for water users, cascading effects to other critical infrastructures and environmental impacts. Vulnerability analyses represent a key point in international risk management programs for protecting critical infrastructure, especially in the context of climate change. In this paper, a methodology is proposed to evaluate crucial water supply infrastructure vulnerabilities based on multiple indicators. A learning-from-experience approach is applied to establish specific indicators for vulnerability assessment. Eight different indicators are identified, divided into four categories, regarding land characteristics, service inefficiencies for users due to infrastructure failure, pipeline route characteristics, and physical characteristics of the aqueduct pipe. Along with the indicators, a graphical representation is proposed using the Kiviat chart, producing a vulnerability chart that represents a useful tool to identify the main vulnerability factors in existing water supply infrastructure, in the management of interventions, in the planning and design processes of new infrastructure, and for comparing different design solutions.
An Overview of the Pharmacological Properties of Calebin-A
Authors: Shamsnia Hedieh , Samanian Amirreza , Sabbagh Kashani Ayeh , Khayatan Danial , Momtaz Saeideh , Johnston Thomas P. , Majeed Muhammed , Jamialahmadi Tannaz , Abdolghaffari Amir Hossein , Sahebkar Amirhossein 
Published: October 2023

Abstract:
The natural polyphenol, calebin-A, was recently discovered and identified as
a novel phytopharmaceutical with anti-inflammatory, anti-tumor, and antiproliferative
properties. Calebin-A occurs naturally in trace quantities in Curcuma longa/C cassia,
commonly known as turmeric, from the Zingiberaceae family. Calebin-A is a curcumin
analog or 'chemical cousin' of curcumin with a similar chemical structure. Although few
research studies have been conducted on the pharmacological and therapeutic properties
of calebin-A, it is a very promising molecule with a variety of pharmacological properties. Some studies have suggested that calebin-A is helpful in treating various cancers
due to its inhibitory effect on cell growth and anti-inflammatory properties. Other
studies have suggested that calebin-A may improve neurocognitive status associated
with neurodegeneration caused by Alzheimer’s disease (AD) by inhibiting the aggregation of β-amyloid. Finally, several studies have proposed that calebin-A may potentially
be therapeutically beneficial in treating patients with obesity. This novel compound
downregulates nuclear factor (NF)-κB-mediated processes involved with cancer, such as
tumor cell invasion, proliferation, metastasis, and, most profoundly, inflammation. Moreover, calebin-A influences the activities of mitogen-activated protein kinases (MAPKs)
in cancer cells. The present review identifies and discusses the pharmacological and phytochemical properties of calebin-A, as well as its therapeutic benefits and limitations, for
future scientists and clinicians interested in exploring calebin-A’s medicinal qualities.
Biochemistry, Mechanistic Intricacies, and Therapeutic Potential of Antimicrobial Peptides: An Alternative to Traditional Antibiotics
Authors: Dwivedi Manish , Parmar Meet Dineshbhai , Mukherjee Debalina , Yadava Anuradha , Yadav Hitendra , Saini Nandini Pankaj 
Published: October 2023

:
The emergence of drug-resistant strains of pathogens becomes a major obstacle
to treating human diseases. Antibiotics and antivirals are in the application for a long
time but now these drugs are not much effective anymore against disease-causing drugresistant
microbes and gradually it is becoming a serious complication worldwide. The
development of new antibiotics cannot be a stable solution to treat drug-resistant strains
due to their evolving nature and escaping antibiotics. At this stage, antimicrobial peptides
(AMPs) may provide us with novel therapeutic leads against drug-resistant pathogens.
Structurally, antimicrobial peptides are mostly α-helical peptide molecules with
amphiphilic properties that carry the positive charge (cationic) and belong to host defense
peptides. These positively charged AMPs can interact with negatively charged bacterial
cell membranes and may cause the alteration in electrochemical potential on bacterial
cell membranes and consequently lead to the death of microbial cells. In the present
study, we will elaborate on the implication of AMPs in the treatment of various diseases
along with their specific structural and functional properties. This review will provide information
which assists in the development of new synthetic peptide analogues to natural
AMPs. These analogues will eliminate the limitations of natural AMPs like toxicity
and severe hemolytic activities.
Deciphering Molecular Mechanisms of Carbon Tetrachloride-
Induced Hepatotoxicity: A Brief Systematic Review
Authors: Fareed Muhammad Mazhar , Khalid Hina , Khalid Sana , Shityakov Sergey 
Published: October 2023

Abstract:
The liver plays a critical role in metabolic processes, making it vulnerable to
injury. Researchers often study carbon tetrachloride (CCl4)-induced hepatotoxicity in
model organisms because it closely resembles human liver damage. This toxicity
occurs due to the activation of various cytochromes, including CYP2E1, CYP2B1,
CYP2B2, and possibly CYP3A, which produce the trichloromethyl radical (CCl3*).
CCl3* can attach to biological molecules such as lipids, proteins, and nucleic acids,
impairing lipid metabolism and leading to fatty degeneration. It can also combine with
DNA to initiate hepatic carcinogenesis. When exposed to oxygen, CCl3* generates
more reactive CCl3OO*, which leads to lipid peroxidation and membrane damage. At
the molecular level, CCl4 induces the release of several inflammatory cytokines,
including TNF-α and NO, which can either help or harm hepatotoxicity through cellular
apoptosis. TGF-β contributes to fibrogenesis, while IL-6 and IL-10 aid in recovery by
minimizing anti-apoptotic activity and directing cells toward regeneration. To prevent
liver damage, different interventions can be employed, such as antioxidants, mitogenic
agents, and the maintenance of calcium sequestration. Drugs that prevent CCl4-
induced cytotoxicity and proliferation or enhance CYP450 activity may offer a
protective response against hepatic carcinoma.