bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravoxel incoherent motion imaging to assess the acute effects of moderate‐intensity continuous training and high‐intensity interval training on thigh muscles
Authors: Li Jiao , Lu Zepeng , Yuan Ling , Wang Qin , Zhu Jinxia , Bao Dapeng , Grimm Robert , Wang Xiao , Wang Xiaoye , Xue Huadan , Jin Zhengyu 
Published: October 2023

AbstractThis study investigated the use of intravoxel incoherent motion imaging (IVIM) to compare skeletal muscle perfusion during and after high‐intensity interval training (HIIT) and moderate‐intensity continuous training (MICT) to determine the impact on fat oxidation outcomes. Twenty overweight volunteers were recruited for the study. Each participant received one HIIT intervention and one MICT intervention using a cycling ergometer. Participants underwent a magnetic resonance imaging scan before, immediately after, and 1 and 2 h after each intervention. The IVIM parameters (D, fD*) of the rectus femoris, vastus lateralis, and biceps femoris long head were obtained. Changes in IVIM parameters of these muscles after both exercise interventions were compared using a two‐factor repeated measures analysis of variance. In the rectus femoris, the fD* increased immediately after exercise intervention (d = 0.69 × 10−3 mm2/s, p < 0.0083) and 2 h after exercise intervention (d = 0.64 × 10−3 mm2/s, p < 0.0083) compared with before exercise. The increase in the fD* in the HIIT group was greater than that in the MICT group (d = 0.32, p = 0.023). In the vastus lateralis, the fD* increased immediately after the exercise intervention (d = 0.53 × 10−3 mm2/s, p < 0.001) and returned to the pre‐exercise level 1 h after exercising. The increase in the fD* in the HIIT group was lower than that in the MICT group (d = −0.21, p = 0.015). For the biceps femoris long head, the fD* was not significantly different between the two exercise interventions before and after exercise. Furthermore, the fD* 60 min after the HIIT intervention correlated with maximal oxygen consumption (VO2max), whereas fD* immediately after the MICT intervention correlated with VO2max. In summary, IVIM parameters can be used to evaluate differences in muscle perfusion between HIIT and MICT, and show a correlation with VO2max.
A semi‐Lagrangian ε$$ \varepsilon $$‐monotone Fourier method for continuous withdrawal GMWBs under jump‐diffusion with stochastic interest rate
Authors: Lu Yaowen , Dang Duy‐Minh 
Published: October 2023

AbstractWe develop an efficient pricing approach for guaranteed minimum withdrawal benefits (GMWBs) with continuous withdrawals under a realistic modeling setting with jump‐diffusions and stochastic interest rate. Utilizing an impulse stochastic control framework, we formulate the no‐arbitrage GMWB pricing problem as a time‐dependent Hamilton‐Jacobi‐Bellman (HJB) Quasi‐Variational Inequality (QVI) having three spatial dimensions with cross derivative terms. Through a novel numerical approach built upon a combination of a semi‐Lagrangian method and the Green's function of an associated linear partial integro‐differential equation, we develop an ‐monotone Fourier pricing method, where is a monotonicity tolerance. Together with a provable strong comparison result for the HJB‐QVI, we mathematically demonstrate convergence of the proposed scheme to the viscosity solution of the HJB‐QVI as . We present a comprehensive study of the impact of simultaneously considering jumps in the subaccount process and stochastic interest rate on the no‐arbitrage prices and fair insurance fees of GMWBs, as well as on the holder's optimal withdrawal behaviors.
Fast Preparation of W States by Designing the Evolution Operators with Rydberg Superatom
Authors: Zhang Wei‐Yue , Wang Cai‐Qing , Ji Yan‐Qiang , Shao Qiu‐Ping , Wang Ji‐Ping , Wang Jie , Yang Li‐Ping , Dong Li , Xiu Xiao‐Ming 
Published: October 2023

AbstractW states play an important role in quantum information processing and quantum computing. Here, it proposes a scheme for preparing W states by designing the evolution operators with Rydberg superatoms. It encodes quantum information on the effective energy level of the superatom, and construct shortcuts to adiabatic passages (STAP) by designing the evolution operators. Combined with Quantum Zeno dynamics and STAP, it can prepare three‐particle W states quickly and efficiently. In addition, the Rabi frequency in this scheme can be described as a linear superposition of Gaussian functions, which reduces the difficulty of practical experiment. The numerical simulation shows that the scheme is robust against decoherence, operational imperfection, and noise. At last, it generalizes this scheme to preparation of N‐particle W states.
Supramolecular dissipative self‐assembly systems: Approaches and applications
Authors: Hou Xiao‐Fang , Chen Xiao , Wei Jia‐Hao , Xu Yang , Chen Xu‐Man , Li Quan 
Published: October 2023

AbstractDissipative self‐assembly (DSA) system requires a continuous supply of fuels to maintain the far‐from‐equilibrium assembled state. Living organisms exist and operate far from the thermodynamic equilibrium by continuous consumption of energy taken from the surroundings, so how to realize the construction of the artificial DSA system has attracted much attention by researchers all over the world. Owing to dynamic controllable noncovalent interactions, artificial supramolecular DSA systems have achieved higher functions fueled by various types of energy, such as chemical fuels, light, electric energy, acoustic energy, and mechanical energy. Upon the input of external fuels, nonactive precursors can be activated to form building blocks at higher energy levels and then self‐assemble into transient supramolecular structures. As the proceeding of deactivation reaction, the building blocks with higher energy level dissipate back to the initial precursors, resulting in the disassembly process, to complete a full cycle. In this review, we summarize the recent advances of artificial supramolecular DSA systems on its construction strategies and energy‐fueled regulation approaches. The applications of supramolecular DSA systems in luminescence modulating, information encryption, self‐regulating gels, drug delivery, and catalysis are also discussed. We hope that this review article will facilitate further understanding and development of DSA systems.
Early life adversity and adolescent sleep problems during the COVID‐19 pandemic
Authors: Bridgewater Jessie M. , Berzenski Sara R. , Doan Stacey N. , Yates Tuppett M. 
Published: October 2023

AbstractThe COVID‐19 pandemic resulted in a reorganization of adolescents' routines, especially their sleep schedules. Utilising 175 caregiver‐adolescent dyads, the current study examined associations of biological (e.g., prenatal substance use), environmental (e.g., poverty), and relational (e.g., child maltreatment) subtypes of early life adversity (ELA) with various components of adolescents' sleep across the first year of the COVID‐19 pandemic. Relational ELA explained unique variance in adolescents' sleep disturbances, but not other sleep components, following short‐ and longer‐term exposure to the COVID‐19 pandemic. However, the direction of this association switched such that relational ELA predicted decreased sleep disturbances during the initial phase of the U.S. COVID‐19 pandemic in spring 2020 beyond pre‐pandemic levels, but, over time, contributed to increased sleep disturbances beyond early‐pandemic levels as the pandemic extended into the winter of 2020.
A Biomimetic Se‐nHA/PC Composite Microsphere with Synergistic Immunomodulatory and Osteogenic Ability to Activate Bone Regeneration in Periodontitis
Authors: Ming Piaoye , Liu Yunfei , Yu Peiyang , Jiang Xueyu , Yuan Linlin , Cai Shuyu , Rao Pengcheng , Cai Rui , Lan Xiaorong , Tao Gang , Xiao Jingang 
Published: October 2023

AbstractAccumulation of reactive oxygen species (ROS) in periodontitis exacerbates the destruction of alveolar bone. Therefore, scavenging ROS to reshape the periodontal microenvironment, alleviate the inflammatory response and promote endogenous stem cell osteogenic differentiation may be an effective strategy for treating bone resorption in periodontitis. In this study, sericin‐hydroxyapatite nanoparticles (Se‐nHA NPs) are synthesized using a biomimetic mineralization method. Se‐nHA NPs and proanthocyanidins (PC) are then encapsulated in sericin/sodium alginate (Se/SA) using an electrostatic injection technique to prepare Se‐nHA/PC microspheres. Microspheres are effective in scavenging ROS, inhibiting the polarization of macrophages toward the M1 type, and inducing the polarization of macrophages toward the M2 type. In normal or macrophage‐conditioned media, the Se‐nHA/PC microspheres effectively promoted the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). Furthermore, the Se‐nHA/PC microspheres demonstrated anti‐inflammatory effects in a periodontitis rat model by scavenging ROS and suppressing pro‐inflammatory cytokines. The Se‐nHA/PC microspheres are also distinguished by their capacity to decrease alveolar bone loss, reduce osteoclast activity, and boost osteogenic factor expression. Therefore, the biomimetic Se‐nHA/PC composite microspheres have efficient ROS‐scavenging, anti‐inflammatory, and osteogenic abilities and can be used as a multifunctional filling material for inflammatory periodontal tissue regeneration.
Escin‐sorafenib synergy up‐regulates LC3‐II and p62 to induce apoptosis in hepatocellular carcinoma cells
Authors: Hussain Yusuf , Singh Jyoti , Meena Abha , Sinha Rohit Anthony , Luqman Suaib 
Published: October 2023

AbstractIntroductionHepatocellular carcinoma (HCC) is a common solid cancer and the leading cause of cancer deaths worldwide. Sorafenib is the first drug used to treat HCC but its effectiveness needs to be improved, and it is important to find ways to treat cancer that combine sorafenib with other drugs. Synergistic therapies lower effective drug doses and side effects while enhancing the anticancer effect.PurposeIn the present study, the therapeutic potential of sorafenib in combination with escin and its underlying mechanism in targeting liver cancer has been established.Study Design/MethodsThe IC50 of sorafenib and escin against HepG2, PLC/PRF5 and Huh7 cell lines were determined using MTT assay. The combination index, dose reduction index, isobologram and concentrations producing synergy were evaluated using the Chou‐Talaly algorithm. The sub‐effective concentration of sorafenib and escin was selected to analyze cytotoxic synergistic potential. Cellular ROS, mitochondrial membrane potential, annexin V and cell cycle were evaluated using a flow‐cytometer, and autophagy biomarkers were determined using western blotting. Moreover, autophagy was knocked down using ATG5 siRNA to confirm its role. A DEN‐induced liver cancer rat model was developed to check the synergy of sorafenib and escin.ResultsDifferent concentrations of escin reduced the IC50 of sorafenib in HepG2, PLC/PRF5 and Huh7 cell lines. Chou‐Talaly algorithm determined cytotoxic synergistic concentrations of sorafenib and escin in these cell lines. Mechanistically, this combination over‐expressed p62 and LC‐II, reflecting autophagy block and induced late apoptosis, further reconfirmed by ATG5 knockdown. Sorafenib and escin combination reduced HCC serum biomarker α‐feto protein (α‐FP) by 1.5 folds. This combination restricted liver weight, tumor number and size, also, conserved morphological features of liver cells. The combination selectively targeted the G0/G1 phase of cancer cells.ConclusionEscin and sorafenib combination potentially up‐regulates p62 to block autophagy to induce late apoptosis in liver cancer cells.
Analysis of Brazilian consumers' perceptions of cosmetics packaging from a circular economy perspective
Authors: da Silva Ana Cecília Cavalcante , Guarnieri Patricia , Vieira Bárbara de O. , Castelo‐Branco Thaíssa V. 
Published: October 2023

AbstractNowadays, a lot more packaging is used to protect and carry products, since they are no longer sold in bulk. Brazil holds the world's fourth largest consumer market for Hygiene, Perfumery, and Cosmetics—HPC in the world. It can therefore be inferred that there is a large consumption of packaging in this sector. However, the country has with the Brazilian Solid Waste Policy (BSWP), which obligates the implementation of reverse logistics for packaging and introduces the concept of shared responsibility—everyone in the chain is responsible for the waste. This paper aims to analyzed the perception of consumers of the sector of HPC related to the disposal and reverse logistics of packaging of beauty products under the Circular Economy‐CE perspective. For this purpose, we applied an online survey with consumers in the HPC sector in Brazil. Data were analyzed using descriptive statistics. It was identified that consumers lack knowledge about the concepts of CE and BSWP, indicating a need to improve the environmental awareness of the population. However, most consumers showed interest in companies that are concerned with the destination of used packaging.
Conclusion and General Implications of This Study
Authors: Isabekova Gulnaz 
Published: October 2023

AbstractThis chapter summarizes the findings from the two case studies, namely, the Global Fund grants and the “Community Action for Health” project financed by the Swiss Agency for Development and Cooperation, covered in this book and elaborates on what these insights mean to further analysis of aid relationships and the sustainability of health aid. It also outlines the methodological validity of this research, its limitations, analytical contribution, and empirical discoveries. The chapter reiterates major theoretical insights and conclusions on how relationships among stakeholders influence the sustainability of health projects. It also delineates the findings that confirmed, contradicted, and/or were new to the literature on actors’ interactions with each other, health aid, and sustainability. The chapter concludes with considerations for the broader academic and policy implications of this study and its insights and outlines possible directions for further research.
Sustainability of Health Assistance
Authors: Isabekova Gulnaz 
Published: October 2023

AbstractThis chapter aims to provide an empirical operationalization and conceptual definition of sustainability in the context of health aid. Based on an overview of the literature on health interventions, it adapts and extends the existing frameworks to provide a comprehensive basis for analyzing this phenomenon. As sustainability may have diverse and, at times, contradictory connotations for different stakeholders, this chapter encourages a precise empirical operationalization of this term, following Iwelunmor et al. (Implementation Science, 11, 1–27, 2016). Conceptually, this chapter adopts Shediac-Rizkallah and Bone’s (Health Education Research, 13, 87–108, 1998) definition of sustainability as maintaining benefits, continuity of project activities, and building the capacity of a recipient community but extends it by further clarifying “community” and “capacity-building.” To this end, it builds on the works of Labonte and Laverack (Critical Public Health, 11(2), 111–127, 2001a, Critical Public Health, 11(2), 129–138, 2001b) and insights the author of this book gained during her fieldwork in the Kyrgyz Republic. Furthermore, acknowledging the high level of uncertainty associated with the assessment of sustainability, this chapter outlines the critical factors associated with the sustainability of health aid. These are financing; the political and economic situation in the recipient country; historical, systemic, and cultural factors pertinent to the context; and organizational factors related to the health intervention itself.
Sustainability of the “Community Action for Health” Project
Authors: Isabekova Gulnaz 
Published: October 2023

AbstractThis chapter aims to assess the sustainability of the “Community Action for Health” project by expanding on the continuity of project activities, maintaining benefits, and building the capacity of a recipient community (Shediac-Rizkallah & Bone, 1998). Focusing on community-based organizations, it also elaborates on their leadership, mobilization of resources (Labonte & Lervack, Capacity building in health promotion, Part 1: For whom? And for what purpose? Critical Public Health, 11(2), 111–127. https://doi.org/10.1080/09581590110039838, 2001a; Capacity building in health promotion, Part 2: Whose use? And with what measurement? Critical Public Health, 11(2), 129–138. https://doi.org/10.1080/09581590110039847, 2001b), and survival beyond the duration of the project funding. This chapter commences with a description of the project, its goals, and its relation to national health policy. Then, it zooms into the continuity of tuberculosis and HIV/AIDS-related activities by overviewing their dynamics during and beyond the project duration and what roles the socioeconomic and political factors had in this process. Furthermore, it assesses the availability of training and handouts essential to the quality of health-related information provided by community-based organizations established within the framework of the “Community Action for Health” initiative. Finally, this chapter elaborates on the capacities of these organizations, meaning their survival beyond the project duration, their mobilization of resources, leadership, mutual support, and activities, also in the face of the COVID-19 pandemic.
Aid Relationships and Power Dynamics in the “Community Action for Health” Project
Authors: Isabekova Gulnaz 
Published: October 2023

AbstractThis chapter discusses the types of aid relationships formed between stakeholders involved in the “Community Action for Health” project. Building on the theoretical framework and empirical findings presented in the previous chapters of this book, it shows how power dynamics evolved in the project and how structural factors were conducive to supporting or changing these dynamics. This chapter also demonstrates how the actors’ changing roles throughout the project life cycle and the ways they created power (based on Haugaard, European Journal of Social Theory, 6(1), 87–113, 2003) and approached their resources were critical to the development of these dynamics. This discussion of power dynamics lays the foundation for identifying the specific types of relationships formed between aid providers (donor–donor), providers with recipients (donor–recipient state, donor–civil society organization), and aid recipients with each other (recipient state–civil society organization). Along with defining the specific types, this chapter expands on the stakeholders’ reasons for forming and maintaining the selected aid relationships.
Safety and Subcontracting
Authors: Le Coze Jean-Christophe 
Published: October 2023

AbstractThe aim of this introductory chapter is to provide a description of the evolving operating landscape of safety-critical systems (e.g. aviation, chemical and nuclear industries, railway) in the past two to three decades, towards network configurations based on contracting out. The topic of this book is strongly connected to this evolution and our understanding of its consequences for safety. The chapter situates the rise of these network configurations in the context of the advent of what has been described as globalisation, a phenomenon shaped by the liberalisation of trade and finance; privatisation and deregulation and the development of technology (communication, transport). A distinction between occupational safety and process safety is introduced to remain aware of different situations, depending on their nature, and positions within such networks. The chapter then summarises the different contributions to this book by a range of authors who bring unique lenses to this topic from a diversity of angles.
Introduction
Authors: Bergmann Jonas 
Published: October 2023

AbstractWorldwide, climate hazards increasingly pose existential threats to subsistence farmers, many of whom struggle to manage such hazards where they live because they are multidimensionally poor. As a result, climate impacts are increasingly influencing their migration decisions. Simultaneously, many affected people are either unable to leave risk areas or do not wish to do so (immobility). Both migrating from and remaining in areas facing climate hazards can have sweeping and enduring impacts on the well-being of affected people. Nevertheless, the implications of climate migration and immobility (or climate (im)mobilities) for people’s well-being remain poorly understood. Few studies provide comprehensive analyses of how moving or staying influences multiple facets of objective need fulfillment. Even less research examines how affected people self-evaluate their lives, how they feel, and how they look to the future in these situations.
In this interdisciplinary, mixed methods dissertation, I address these gaps by dissecting multidimensional well-being impacts related to varied climate (im)mobilities within Peru. The study examines the four major types of climate (im)mobilities, namely migration, displacement, relocation, and immobility. By assessing multidimensional well-being effects and their mechanisms of action, the dissertation pursues two main goals. First, it informs debates about the potential of migration as an adaptation strategy and about loss and damage due to climate change. Second, it provides evidence that can support development and adaptation planning to safeguard the well-being of the growing number of climate migrants and people in immobility. This introduction chapter sets the stage by discussing the context and scope of the study as well as the research questions and objectives. It concludes with a preview of the structure of the dissertation and the following chapters.
Lebensqualität von kleinwüchsigen Kindern und Jugendlichen und Wachstumshormontherapie
Authors: Quitmann Julia Hannah , Binder Gerhard , Witt Stefanie , Bullinger Monika , Blömeke Janika , Fricke-Otto Susanne , Hauffa Berthold , Kahrs Sabine , Partsch Carl-Joachim , Rohenkohl Anja , Dörr Helmuth-Günther 
Published: October 2023

Zusammenfassung
Hintergrund
Wachstumsstörungen können psychosoziale und physische Folgen für die betroffenen Kinder, Jugendlichen und ihre Familien haben.

Fragestellung
Wie wirken sich Wachstumsstörungen und deren Behandlung mit Wachstumshormonen („human growth hormone“, hGH) auf die Lebensqualität von Kindern und Jugendlichen im Kontext von idiopathischem Wachstumshormonmangel („idiopathic growth hormone defiency“, IGHD), idiopathischem Kleinwuchs („idiopathic short stature“, ISS), Turner-Syndrom (TS), „Small-for-gestational-age“(SGA)-Kleinwuchs und Prader-Willi-Syndrom (PWS) aus?

Material und Methoden
Ergebnisse eines multiprofessionellen Arbeitstreffens mit aktueller Literaturrecherche.

Ergebnisse
In Deutschland ist eine hGH-Therapie nicht für alle Indikationen gegeben. Die Lebensqualität von Kindern und Jugendlichen mit Wachstumsstörungen und deren Eltern ist häufig beeinträchtigt, aber nicht zwangsweise. Kinder und Jugendliche mit ISS berichten oftmals eine normale bzw. höhere Lebensqualität als normalwüchsige Peers. Ebenso weisen Kinder mit PWS eine mit Peers vergleichbare Lebensqualität auf, während Kinder mit IGHD eine eingeschränkte Lebensqualität berichten und auch Mädchen mit TS negative Auswirkungen der körperlichen Besonderheiten auf das Selbstwertgefühl und das Sozialleben berichten. Die Zusammenhänge von hGH-Therapie und Lebensqualität weisen inkonsistente Ergebnisse auf; Studien berichten sowohl von einer unveränderten Lebensqualität (TS, IGHD) als auch von einer Verbesserung (IGHD, SGA, PWS).

Diskussion
Pädiatrische Wachstumsstörungen haben z. T. psychosoziale und physische Folgen. Studien zeigen jedoch inkonsistente Forschungsergebnisse. Bei der Beurteilung der Lebensqualität spielen neben der Körperhöhe noch weitere Faktoren eine wichtige Rolle, wie z. B. der familiäre Umgang mit der Erkrankung.