bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children
Authors: Fu Ru-Huei , Wu Po-Yen , Chou I-Ching , Lin Chien-Heng , Hong Syuan-Yu 
Published: January 2024

Abstract
Background
This study aimed to investigate the demographic and clinical characteristics, types of seizure disorders, and antiepileptic drug usage among individuals with different types of corpus callosum disorders.

Methods
A total of 73 individuals were included in the study and divided into three groups based on the type of corpus callosum abnormality: hypoplasia (H), agenesis (A), and dysgenesis (D). Demographic data, including gender and preterm birth, as well as clinical characteristics such as seizure disorders, attention deficit hyperactivity disorder (ADHD), severe developmental delay/intellectual disability, and other brain malformations, were analyzed. The types of seizure disorders and antiepileptic drugs used were also examined.

Results
The H group had the highest number of participants (n = 47), followed by the A group (n = 11) and the D group (n = 15). The A group had the highest percentage of males and preterm births, while the D group had the highest percentage of seizure disorders, other brain malformations, and severe developmental delay/intellectual disability. The A group also had the highest percentage of ADHD. Focal seizures were observed in all three groups, with the highest proportion in the A group. Focal impaired awareness seizures (FIAS) were present in all groups, with the highest proportion in the D group. Generalized tonic-clonic seizures (GTCS) were observed in all groups, with the highest proportion in the H group. Different types of antiepileptic drugs were used among the groups, with variations in usage rates for each drug.

Conclusion
This study provided insights into the demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage among individuals with different types of corpus callosum disorders. Significant differences were found between the groups, indicating the need for tailored management approaches. However, the study has limitations, including a small sample size and a cross-sectional design. Further research with larger sample sizes and longitudinal designs is warranted to validate these findings and explore the relationship between corpus callosum abnormality severity and clinical outcomes.
Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations
Authors: Derayea Sayed M. , Badr El-Din Khalid M. , Ahmed Ahmed S. , Khorshed Ahmed A. , Oraby Mohamed 
Published: January 2024

AbstractFor the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective spectroscopic approach for estimating Montelukast sodium and Bilastine in pharmaceutical dosage form without previous separation. The selected technique focuses on measuring the synchronized fluorescence of the studied medications at a fixed wavelength range (Δλ) = 110 nm, and using the amplitude of the first derivative's peak at 381 and 324 nm, for quantitative estimation of Montelukast sodium and Bilastine, respectively. The impacts of different factors on the referred drugs' synchronized fluorescence intensity were investigated and adjusted. The calibration plots for were found to be linear over concentration ranges of 50–2000 ng mL−1 for Montelukast sodium and 50–1000 ng mL−1 for Bilastine. Montelukast sodium and Bilastine have LODs of 16.5 and 10.9 ng mL−1, respectively. In addition, LOQs were: 49.9 and 33.0 ng mL−1, for both drugs, respectively. The developed method was successfully employed to quantify the two drugs in synthetic tablets mixture and in laboratory prepared mixtures containing varied Montelukast and Bilastine ratios. To compare the results with the published analytical approach, a variance ratio F-test and a student t-test were used, which revealed no significant differences.
Callovian corals from the Swiss Jura
Authors: Löser Hannes , Wetzel Andreas , Hostettler Bernhard 
Published: January 2024

AbstractTwelve solitary and platy, colonial coral taxa assigned to the families Microsolenidae, Misistellidae, Montlivaltiidae, Rayasmiliidae, and Thamnasteriidae are described and illustrated from the Callovian (Ifenthal Formation, Herznach Member) of the area of Andil near Liesberg, about 20 km WSW of the town of Basel, Switzerland. The platy growth forms and the presence of five species of the superfamily Cyclolitoidea suggests that these corals lived under low-level light conditions.
Electrocardiogram prediction based on variational mode decomposition and a convolutional gated recurrent unit
Authors: Wang HongBo , Wang YiZhe , Liu Yu , Yao YueJuan 
Published: January 2024

AbstractElectrocardiogram (ECG) prediction is highly important for detecting and storing heart signals and identifying potential health hazards. To improve the duration and accuracy of ECG prediction on the basis of noise filtering, a new algorithm based on variational mode decomposition (VMD) and a convolutional gated recurrent unit (ConvGRU) was proposed, named VMD-ConvGRU. VMD can directly remove noise, such as baseline drift noise, without manual intervention, greatly improving the model usability, and its combination with ConvGRU improves the prediction time and accuracy. The proposed algorithm was compared with three related algorithms (PSR-NN, VMD-NN and TS fuzzy) on MIT-BIH, an internationally recognized arrhythmia database. The experiments showed that the VMD-ConvGRU algorithm not only achieves better prediction accuracy than that of the other three algorithms but also has a considerable advantage in terms of prediction time. In addition, prediction experiments on both the MIT-BIH and European ST-T databases have shown that the VMD-ConvGRU algorithm has better generalizability than the other methods.
Connected speech features in non-English speakers with Alzheimer’s disease: protocol for scoping review
Authors: Bose Arpita , Ahmed Samrah , Cheng Yesi , Suárez-Gonzalez Aida 
Published: January 2024

Abstract
Background
A large body of literature indicates that connected speech profiles in patients with Alzheimer’s disease (AD) can be utilized for diagnosis, disease monitoring, and for developing communication strategies for patients. Most connected speech research has been conducted in English, with little work in some European languages. Therefore, significant drawback remains with respect to the diversity of languages studied, and how the fragmentation of linguistic features differs across languages in AD. Accordingly, existing reviews on connected speech in AD have focused on findings from English-speaking patients; none have specifically focused on the linguistic diversity of AD populations. This scoping review is undertaken to provide the currently reported characteristics of connected speech in AD in languages other than English. It also seeks to identify the type of assessments, methods to elicit speech samples, type of analysis and linguistic frameworks used, and micro- and macro-linguistic features of speech reported in non-English speakers with AD.

Method
We will conduct a scoping review of published studies that have quantitively assessed connected speech in AD in languages other than English. The inclusion criteria for the studies would be subject/s with a clinical diagnosis of AD. The search will include the electronic databases PubMed, Ovid-Embase, PsycINFO, Linguistic and Language Behaviour Abstracts (LLBA), and Web of Science up until March 2023. Findings will be mapped and described according to the languages studied, the methodology employed (e.g., patient characteristics, tasks used, linguistic analysis framework utilized), and connected speech profiles derived (e.g., micro- and macro-linguistic reported).

Discussion
The scoping review will provide an overview of languages studied in connected speech research in AD with variation in linguistic features across languages, thus allowing comparison with the established key features that distinguish AD patients from healthy controls. The findings will inform future research in connected speech in different languages to facilitate robust connected speech research in linguistically and ethnically diverse populations.
Potential anti-acne loaded nanogel formulations of Origanum majorana L. and Chrysanthemum morifolium Ramat. essential oils
Authors: Kotb Eman A. , El-Shiekh Riham A. , Hassan Mariam , Abd-Elsalam Wessam Hamdy , El Tanbouly Nebal , El Senousy Amira Safwat 
Published: January 2024

AbstractAcne is a highly prevalent skin disease with a great psychological impact on patients as self-perception, self-confidence, and depression. This work aimed to develop an anti-acne preparation from active anti-bacterial medicinal plants to circumvent the severe side effects and drug resistance commonly reported with topical erythromycin anti-acne preparations. Essential oils:Salvia officinalisL. (sage),Rosmarinus officinalisL. (rosemary),Commiphora myrrhaNees Engl. (myrrh),Origanum majoranaL. (marjoram),Pelargonium zonaleL. L’Hér. ex Aiton (geranium) andChrysanthemum morifoliumRamat. (chrysanthemum) were extracted by hydrodistillation and analyzed using gas chromatography/mass spectrometry (GC/MS). The anti-acne activities of the oils againstCutibacteriumacnes ATCC 6919 were evaluated by microdilution methods to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The most active essential oils were loaded in a film-forming nanogel prepared with chitosan, pluronic F127 and glycerol in the ratio of 3:1:1, prior to investigation in a murine acne in vivo model. Marjoram and chrysanthemum oils showed the highest antimicrobial activity againstC. acnes(MIC = 0.156%v/vand 0.125%v/v, respectively). GC/MS of the actives showed that gamma-terpinene (26.46%) and terpinen-4-ol (22.24%) were the predominant constituents in marjoram, whereas chrysanthenone (32.79%) was the main component in chrysanthemum. The formulated essential oil-loaded film-forming nanogels of both oils exhibited significant anti-acne activity in mice via reducing the bacterial loads, activating the antioxidant nuclear factor erythroid 2–related factor 2 (Nrf2) pathway and inhibiting the inflammatory tumor necrosis factor-alpha (TNF-α) pathway. Further studies should be designed to evaluate the clinical evidence for the use of marjoram and chrysanthemum oil products in acne treatment.Graphical Abstract
The medieval bronze doors of San Zeno, Verona: combining material analyses and art history
Authors: Mödlinger M. , Bontadi J. , Fellin M. , Fera M. , Negri M. , Utz J. , Ghiara G. 
Published: January 2024

Abstract
The bronze doors of the Basilica of San Zeno in Verona, Italy, are a special case in art history research. They were made by several workshops during the twelfth century: stylistically, two to three workshops were assumed to produce the metal parts of the door. However, it is still unclear when exactly and if this interpretation can be supported by the chemical composition of the metal. In this research we aimed to verify the art history interpretation by identifying the alloy composition of each individual metal plate. The composition of the supporting wooden structures are discussed. A portable ED-XRF instrument and optical microscopes were used to analyse and document the doors non-invasively. The doors were also photographed to produce high resolution orthophotos and 3D models. We can confirm that the metal parts of the doors were made of leaded tin-bronze as well as leaded brass and mounted on a wooden structure mainly made of spruce and oak wood. Chemically, two/three different groups of alloys have been identified, which can be associated with two or three different workshops, and which largely correspond to the stylistic interpretation.
Didge you sleep: a feasibility study of didgeridoo training for obstructive sleep apnea
Authors: Badami Varun , Abaalkhail Nawaf , Petro Alex , Alessi Cathy , Martin Jennifer L. , Sanchez Maria Cristina , Dzierzewski Joseph M. , Suarez Alex , Fung Constance H. 
Published: January 2024

AbstractIntolerance of positive airway pressure therapy for obstructive sleep apnea is common. Upper airway muscle therapies show promise as alternative treatments. The didgeridoo, which is a musical instrument, can be used for upper airway muscle training. Our goal was to develop a group-based didgeridoo training program for obstructive sleep apnea. We conducted a proof-of-concept single-arm study consisting of a structured didgeridoo training regimen. We surveyed patients at a large medical facility about their interest in the program. We developed and tested a manual of procedures for conducting a 4-session group program conducted over 8 weeks that instructed participants on use of the Medical Didgeridoo. We also refined procedures for baseline and 4-month follow-up assessments, which included measures of daytime sleepiness and apnea–hypopnea index. Interviews were conducted at follow-up to obtain feedback about the program. Of the 56 survey respondents, 67% reported difficulty with positive airway pressure, expressed interest in participating in a structured upper airway muscle training program, and indicated that they would be willing to practice exercises for 30 min per day. After in-depth screening of 15 patients, we recruited five patients to participate in the structured training program; all five completed the program and were able to learn to play basic sounds on the provided instrument, and four stated they would continue to play the Medical Didgeridoo after completion of the program. Given the significant level of interest and excellent participation in the didgeridoo training program, it may be feasible to conduct a large-scale study to assess treatment response.
Morphological and molecular characterisation of Helicotylenchus zengchengensis n. sp. (Nematoda: Hoplolaimidae) from China, with a review on Helicotylenchus species in China
Authors: Chen Yan , Lu Yang , Xie Hui , Xu Chunling 
Published: January 2024

AbstractHelicotylenchus comprises a significant group of plant-parasitic nematodes that primarily feed on plant roots. This study focuses on the description of a newly discovered species, Helicotylenchus zenchengensis n. sp., from China. The distinguishing characteristic of this species, as observed under a microscope, is the absence of head annulation. The stylet, measuring between 23.8 and 29.3 μm, exhibits anteriorly flattened or indented stylet knobs. The elongated tail has a c value ranging from 15.8 to 22.6 and a c’ value between 1.9 and 2.4. It bears 15 to 18 tail annuli, presenting a conical shape with projections. The phasmids are located at the 4th to 10th body annulations posterior to the anus, while no males were observed. Three phylogenetic trees were constructed to determine the evolutionary relationships using the 18S rRNA, ITS, and 28S D2-D3 expansion segments of the newly discovered species and related Helicotylenchus sequences obtained from the database. Based on the ITS sequences, a phylogenetic tree revealed that H. zenchengensis n. sp. clustered with H. cuspicaudatus. However, it was distinguished from H. cuspicaudatus when examining the 18S and 28S rRNA sequences and morphological characteristics. Additionally, comprehensive and diagnostic tables for all known species of Helicotylenchus in China are provided for reference.
Neuroticism, perceived stress, adverse life events and self-efficacy as predictors of the development of functional somatic disorders: longitudinal population-based study (DanFunD)
Authors: Petersen Marie Weinreich , Carstensen Tina Birgitte Wisbech , Wellnitz Kaare Bro , Ørnbøl Eva , Frostholm Lisbeth , Dantoft Thomas Meinertz , Jørgensen Torben , Eplov Lene Falgaard , Fink Per 
Published: January 2024

BackgroundFunctional somatic disorder (FSD) is a unifying diagnosis that includes functional somatic syndromes such as irritable bowel, chronic widespread pain (CWP) and chronic fatigue. Several psychological factors are associated with FSD. However, longitudinal population-based studies elucidating the causal relationship are scarce.AimsTo explore if neuroticism, perceived stress, adverse life events (ALEs) and self-efficacy can predict the development of FSD over a 5-year period.MethodA total of 4288 individuals who participated in the DanFunD baseline and 5-year follow-up investigations were included. FSD was established at both baseline and follow-up, with symptom questionnaires and diagnostic interviews. Neuroticism was measured with the short-form NEO Personality Inventory, perceived stress with the Cohen's Perceived Stress Scale, ALEs with the Danish version of the Cumulative Lifetime Adversity Measure and self-efficacy with the General Self-Efficacy Scale. Associations were investigated with multiple logistic regression models.ResultsPerceived stress predicted incident FSD, irritable bowel, CWP and chronic fatigue (odds ratios: 1.04–1.17). Neuroticism predicted incident FSD and chronic fatigue (odds ratios: 1.03–1.16). ALEs predicted incident FSD, CWP and chronic fatigue (odds ratios: 1.06–1.18). An increase in perceived stress from baseline to follow-up was associated with incident FSD, irritable bowel, CWP and chronic fatigue (odds ratios: 1.05–1.22). Contrary, an increase in self-efficacy seemed to be a protective factor (odds ratios: 0.89–0.99).ConclusionsHigh neuroticism, high perceived stress and a high number of ALEs are risk factors for the development of FSD. Particularly perceived stress seems to be an important contributor to the onset of FSD.
Integrating reality counseling with the creative arts as a counselor's professional practice: A review literature
Authors: Titing Herman 
Published: January 2024

Counselor creativity is one aspect that needs to be strengthened by counselors in providing counseling services. The creativity of this counselor can encourage the emergence of meaningful counseling services and significantly impact changes in counselee behavior. This article explains the integration of reality counseling with the creative arts. This article is a structured and systematic literature review of the development of ideas and reality counseling research related to the creative arts. This article is an analysis of 51 articles published from 2010 to 2020. In addition, three scientific articles directly relate to combining creative arts and reality counseling. A study of these articles found that creative arts can increase the effectiveness of reality counseling with the WDEP (wants, doing, evaluation, planning) system pattern. Creative arts supporting the efficacy of the WDEP system pattern of reality counseling are drawings, puppets, metaphors, and sand trays. The combination of reality counseling by utilizing creative arts such as drawing, puppets, metaphors, and sand trays produces operational guidelines for counselors consisting of four counseling sessions. Integrating creative arts into reality counseling is a form of professionalism for counselors in counseling services. Operating procedures for combining reality counseling with creative arts are discussed in this article. The findings of this study provide recommendations for further research to identify the effectiveness of counseling empirically in overcoming specific problems in counselees.
Enhancing quality in same-day emergency care: a service improvement perspective
Authors: Gibson Sally , Duffy Richelle 
Published: January 2024

Background: Same-day emergency care (SDEC) units were introduced in the UK in response to growing numbers of emergency department visits. Key quality indicators for their performance include timely assessment, diagnosis and treatment to reduce delays and optimise care delivery. Aims: This article presents the findings from a multi-cycle service improvement project undertaken at a regional SDEC unit from the perspective of the advanced clinical practitioner (ACP). Methods: The SI project adopted an array of SI methodologies, including the Plan, Do, Study, Act model, process mapping and audit data analytics to identify and reduce variance in patient care. Results: The project identified the importance of adopting a whole-system approach to clinical leadership to improve the care experience of patients and staff. Success is highly dependent on the availability of a confident and skilled workforce to provide high-quality patient care. Conclusions: As demands on emergency health services continue to grow, the ACP is in an ideal position to adapt to change and generate innovative solutions to address capacity issues.
Potential of endophytic yeasts as biocontrol of Phytophthora capsici, causative agent of foot rot disease on black pepper
Authors: SAFITRI DIAN , WIYONO SURYO , PURBAJANTI ENDANG DWI 
Published: January 2024

Abstract. Safitri D, Wiyono S, Purbajanti ED. 2023. Potential of endophytic yeasts as biocontrol of Phytophthora capsici, causative agent of foot rot disease on black pepper. Biodiversitas 24: 5847-5853. Phytophthora capsici is the main pathogen of foot rot disease of black pepper. This disease contributes to a significant decrease in black pepper productivity. Conventional disease management strategies usually require the use of chemical pesticides, which can have harmful environmental and human health consequences. Introducing biological agents such as endophytic yeasts for controlling foot rot disease has minimal effect on human health and is sustainable. One technique to control foot rot disease is to use biological agents such as endophytic yeasts. The aim of this research was to find yeast against Phytophthora capsici. The methods used included (i) study development and identification of endophytic yeast and (ii) in vitro and in vivo antagonism screening of yeast against P. capsici. The results showed that 49 endophytic yeasts were isolated from the leaves, fruits and roots of three black pepper lines. Five isolates had selected based on the highest antibiosis in antagonism test by in vitro: END6, END21, END66, END87, and END14. Isolate END87 had a mycelium inhibition rate of 64.55%, and a low level of inhibition was found in isolate 21, which had a mycelium size of 42.81%. The molecular characterization based on the sequence partial of NL1 and NL4. Moreover, 5 isolates of endophytic yeast (END6, END21, END66, END87, and END14) were identified as Rhodotorula mucilaginosa, Hannaella oryzae, Cryptococcus tephrensis.