bluuebunny/crossref_metadata_2025_split huggingface dataset:
Land potential assessment and trend-analysis using 2000–2021 FAPAR monthly time-series at 250 m spatial resolution
Authors: Hackländer Julia , Parente Leandro , Ho Yu-Feng , Hengl Tomislav , Simoes Rolf , Consoli Davide , Şahin Murat , Tian Xuemeng , Jung Martin , Herold Martin , Duveiller Gregory , Weynants Melanie , Wheeler Ichsani 
Published: January 2024

Abstract
The paper presents results of using remote sensing images and machine learning to map and assess land potential based on time-series of potential Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) composites. Land potential here refers to the potential vegetation productivity in the hypothetical absence of short–term anthropogenic influence, such as intensive agriculture and urbanization. Knowledge on this ecological land potential could support the assessment of levels of land degradation as well as restoration potentials. Monthly aggregated FAPAR time-series of three percentiles (0.05, 0.50 and 0.95 probability) at 250 m spatial resolution were derived from the 8-day GLASS FAPAR V6 product for 2000-2021 and used to determine long-term trends in FAPAR, as well as to model potential FAPAR in the absence of human pressure. CCa 3 million training points sampled from 12,500 locations across the globe were overlaid with 68 bio-physical variables representing climate, terrain, landform, and vegetation cover, as well as several variables representing human pressure including: population count, cropland intensity, nightlights and a human footprint index. The training points were used in an ensemble machine learning model that stacks three base learners (Extremely Randomized Trees, Gradient Descended Trees and Artificial Neural Network) using a linear regressor as meta-learner. The potential FAPAR was then projected by removing the impact of urbanization and intensive agriculture in the covariate layers. The results of strict cross-validation show that the global distribution of FAPAR can be explained with an R2 of 0.89, with the most important covariates being growing season length, forest cover indicator and annual precipitation. From this model, a global map of potential monthly FAPAR for the recent year (2021) was produced, and used to predict gaps in actual vs. potential FAPAR. The produced global maps of actual vs potential FAPAR and long-term trends were each spatially matched with stable and transitional land cover classes. The assessment showed large negative FAPAR gaps (actual lower than potential) for classes: urban, needle-leave deciduous trees, and flooded shrub or herbaceous cover, while strong negative FAPAR trends were found for classes: urban, sparse vegetation and rainfed cropland. On the other hand, classes: irrigated or post-flooded cropland, tree cover mixed leaf type, and broad-leave deciduous showed largely positive trends. The framework allows land managers to assess potential land degradation from two aspects: as an actual declining trend in observed FAPAR and as a difference between actual and potential vegetation FAPAR.
The Effectiveness of Digital Communication Media to Improve Adolescent Resilience Skills for Preventing Mental Health Problems: A Scoping Review Protocol
Authors: Rachmayanti Riris Diana , Dewi Fatwa Sari Tetra , Setiyawati Diana , Megatsari Hario , Diana Rian , Vinarti Retno Aulia 
Published: January 2024

Abstract
Background
The global databases reveal a high prevalence of mental health problems among adolescents, with 13.50% for ages 10–14 and 14.65% for ages 15–19. Successful coping depends on the risks and protective factors, and their interplay influencing resilience. Higher resilience correlates with lower mental health problems. Digital mental health holds promise for addressing mental health problems.
Purpose
This protocol serves as a framework for planning a scoping review to map the types and effectiveness of digital communication media in intervention to increase youth resilience.
Methods
Six steps to conduct a scoping review based on Arksey and O'Malley 2015 guidelines are applied: 1) defining the research questions by the PICO framework. The population is adolescent youth, young people, and teenagers. Intervention is digital health. The comparator is not using media or no digital media or non-digital. And outcome is resilience (coping mechanism, coping with stress) and well-being or positive mental health. 2) identifying relevant studies. We will identify all scoping reviews that are relevant and completed before 2023. 3) study selection. We will select articles for titles, abstracts, and full text by three independent reviewers based on the inclusion and exclusion criteria. 4) charting the data by Excel conducts essential information such as Study characteristics, description of digital health, variables relating to process, and research. 5) collating, summarising, and reporting the results. Synthesis focuses on (1) the typology of media used to intervene in adolescent resilience skills; and (2) the impact of media on adolescent resilience skills. Analysis by quantitative and qualitative, and 6) consultation with the research team or psychiatrist will be performed when additional data or information is needed.
Discussion
The results of the study will provide a comprehensive overview of commonly used digital media types and their effectiveness on youth resilience. Thus, the results of this scoping review protocol can serve as foundational evidence in determining further research or interventions.
Register Scoping Review :
The Scoping Review protocol was registered on Open Science Framework (OSF.IO/3CNRT)
Finite Element Models with Automatic Computed Tomography Bone Segmentation for Failure Load Computation
Authors: Saillard emile , Gardegaront Marc , Bermond Francois , Mitton David , Pialat jean-Baptiste , Confavreux Cyrille , Grenier Thomas , Follet Helene 
Published: January 2024

Abstract

Bone segmentation is an important step to perform biomechanical failure load simulations on in-vivo CT data of patients with bone metastasis, as it is a mandatory operation to obtain meshes needed for numerical simulations. Segmentation can be a tedious and time consuming task when done manually, and expert segmentations are subject to intra- and inter-operator variability. Deep learning methods are increasingly employed to automatically carry out image segmentation tasks. These networks usually need to be trained on a large image dataset along with the manual segmentations to maximize generalization to new images, but it is not always possible to have access to a multitude of CT-scans with the associated ground truth. It then becomes necessary to use training techniques to make the best use of the limited available data. In this paper, we propose a dedicated pipeline of preprocessing, deep learning based segmentation method and post-processing for in-vivo human femurs and vertebrae segmentation from CT-scans volumes. We experimented with three U-Net architectures and showed that out-of-the-box models enable automatic and high-quality volume segmentation if carefully trained. We compared the failure load simulation results obtained on femurs and vertebrae using either automatic or manual segmentations and studied the sensitivity of the simulations on small variations of the automatic segmentation. The failure loads obtained using automatic segmentations were comparable to those obtained using manual expert segmentations for all the femurs and vertebrae tested, demonstrating the effectiveness of the automated segmentation approach for failure load simulations.
Dynamic clade transitions and the influence of vaccine rollout on the spatiotemporal circulation of SARS-CoV-2 variants in São Paulo, Brazil
Authors: Nogueira Maurício , Banho Cecília , Marques Beatriz , Sacchetto Livia , Lima Ana Karoline , Parra Maisa Carla , Lima Alex , Ribeiro Gabriela , Martins Antonio , Barros Claudia , Elias Maria , Sampaio Sandra , Slavov Svetoslav , Rodrigues Evandra , Santos Elaine , Covas Dimas , Kashima Simone , Brassaloti Ricardo , Petry Bruna , Clemente Luan , Coutinho Luiz , Assato Patricia , Costa Felipe , Souza-Neto Jayme , Grotto Rejane , Poleti Mirele , Lesbon Jessika , Mattos Elisangela , Fukumasu Heidge , Giovanetti Marta , Alcantara Luiz Carlos , Rahal Paula , Araújo João , Spilki Fernando , Althouse Benjamin , Vasilakis Nikos 
Published: January 2024

Abstract

Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence of new mutations that may enhance viral fitness, leading to the persistence of the disease. Due to limitations in the real-time genomic monitoring of new variants in some Brazilian states, we aimed to investigate whether genomic surveillance, coupled with epidemiological data and SARS-CoV-2 variants spatiotemporal spread in a smaller region, can reflect the pandemic progression at a national level. Our findings revealed three SARS-CoV-2 variant replacements from 2021 to early 2022, corresponding to the introduction and increase in the frequency of Gamma, Delta, and Omicron variants, as indicated by peaks of the Effective Reproductive Number (Reff). These distinct clade replacements triggered two waves of COVID-19 cases, influenced by the increasing vaccine uptake over time. Our results indicated that the effectiveness of vaccination in preventing new cases during the Delta and Omicron circulations was six and eleven times higher, respectively, than during the period when Gamma was predominant, and it was highly efficient in reducing the number of deaths. Furthermore, we demonstrated that genomic monitoring at a local level can reflect the national trends in the spread and evolution of SARS-CoV-2.
The Prognosis of Pediatric Intensive Care Unit Patients Can Be Affected by Gamma Glutamyl transferase and Uric Acid Levels: A systematic review with Meta-Analysis.
Authors: Baloch Muhammad Daniyal , Abduhaer Abulaiti , Hairula Nadire 
Published: January 2024

Abstract
Background: Elevated Gamma Glutamyl transferase (GGT) and uric acid levels have been associated with worse outcomes in critically ill patients, but their predictive value in Pediatric Intensive Care Unit (PICU) patients is unclear. We conducted a systematic review and meta-analysis to evaluate the association between GGT/uric acid and mortality in PICU patients.
Methods: PubMed, Embase and Cochrane Library were searched for observational studies examining the association between GGT/uric acid levels and mortality in PICU patients. Pooled risk ratios (R.R.) with 95% confidence intervals (CI) were calculated using random-effects models.
Results: 8 studies with 2,134 patients were included. Elevated GGT was associated with significantly higher mortality risk (RR 1.86, 95% CI 1.34-2.58). The association remained significant when restricted to multivariate analyses (RR 1.95, 95% CI 1.17-3.26). Elevated uric acid levels were also associated with higher mortality (RR 1.97, 95% CI 1.33-2.90). Significant heterogeneity was present.
Conclusions: Elevated Gamma Glutamyl transferase (GGT) and uric acid levels are associated with higher mortality risk in Pediatric Intensive Care Unit (PICU) patients. These biomarkers may assist in risk stratification, although additional studies are needed to confirm these findings.
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress
Authors: Claessen Dennis , Zhong Xiaobo , Baur Sarah , Ongenae Veronique , Egido Guillermo Guerrero , Shitut Shraddha , Du Chao , Vijgenboom Erik , Wezel Gilles van , Brava Victor Carrion , Briegel Ariane , Bramkamp Marc 
Published: January 2024

Abstract
The cell wall represents an essential structure conserved among most bacteria, playing a crucial role in growth and development. While extensively studied model bacteria have provided insights into cell wall synthesis coordination, the mechanism governing polar growth in actinobacteria remains enigmatic. Here we identify the stomatin-like protein StlP as a pivotal factor essential for orchestrating polar growth in filamentous actinobacteria under hyperosmotic stress. StlP facilitates the establishment of a membrane microdomain with increased membrane fluidity, a process crucial for maintaining proper growth. The absence of StlP leads to branching of filaments, aberrant cell wall synthesis, thinning of the cell wall, and the extrusion of cell wall-deficient cells at hyphal tips. StlP interacts with key components of the apical glycan synthesis machinery, providing protection to filaments during apical growth. Introduction of StlP in actinobacteria lacking this protein enhances polar growth and resilience under hyperosmotic stress, accompanied by the formation of a membrane microdomain. Our findings imply that stomatin-like proteins, exemplified by StlP, confer a competitive advantage to actinobacteria encountering hyperosmotic stress. Given the widespread conservation of StlP in filamentous actinobacteria, our results propose that the mediation of polar growth through membrane microdomain formation is a conserved phenomenon in these bacteria.
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
Authors: xu songhui , Li Sheng , Xiong Situ , Li Zhongqi , Yang Lin , Yang Hailang , Xiong Yunqiang , Zhan Xiangpeng , Dong Qianxi , Hu Hongji , Zheng Fuchun , Wan Hao , Liu Xiaoqiang , Wang Zhipeng , Wu Shuyu , Du Yuanzhuo , Guo Biao , Xiong Jing , Pan Wang , Guo Ju , Fu Bin 
Published: January 2024

Abstract
The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 can cause neurodevelopmental disorder and Williams syndrome. However, the molecular mechanism underlying the regulation of SMARCA5 in prostate cancer remains largely elusive. Here, we report that the deubiquitinating enzyme USP3 directly interacts with SMARCA5 and removes K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance. Depletion of USP3 or SMARCA5 promoted PCa cells sensitive to docetaxel and overexpression of USP3 restored the cells resistance to docetaxel treatment in SMARCA5 silenced cells in vitro and vivo. Clinically, USP3 was significantly up-regulated in prostate cancer tissues and positively associated with SMARCA5 expression. Collectively, our findings uncover a novel molecular mechanism for the USP3-SMARCA5 axis in regulating DSB repair with an important role in chemotherapy response in human prostate cancers, highlighting that targeting USP3-SMARCA5 axis could be a valuable strategy to treat USP3/SMARCA5-overexpressing chemotherapy-resistant patients and improve drug treatment.
A rare case of combined endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrical deep endometriosis
Authors: Zhou Cailu , Luo Xiaojing , Tang Mengjie , Luo Fangyuan , Liao Zhi 
Published: January 2024

Abstract

Background Carcinomatous changes from the ectopic endometrial glands in endometriosis have been reported in many studies, but malignant transformation from uterine adenomyosis/adenomyoma is rare. And clear cell-like adenocarcinoma represents a seldom-encountered malignant pathological variant of ectopic endometrium. Case presentation This case report presents a case of a 44-year-old nulliparous woman begun with abdominal pain and intestinal obstruction. Past medical history showed laparoscopic ovarian endometriotic cyst excision. Ultrasound indicated adenomyoma and a parametrical hypoechoic nodule with abundant blood flow signals and unclear boundaries. Deep invasive endometriosis was considered preoperatively. The patient underwent laparoscopic subextensive hysterectomy and bilateral adnexa resection. Chocolate cyst-like lesion was observed in the parametral lesion. Postoperative pathological examinations suggested endometrioid adenocarcinoma arising from eutropic endometrium and adenomyoma. Left parametrical lesions suggested poorly differentiated endometrioid adenocarcinoma combined with clear cell carcinoma. CD10 + endometrial stromal cells were observed surrounding tumor cell masses. The patient underwent subsequent transabdominal tumor cell reduction surgery and chemotherapy. Combined with surgical founding and pathological characters of the left parametrical adenocarcinoma, the parametrial lesions were more likely to be carcinomatous changes of the original deep endometriosis. Conclusion We herein present a rare case of combined endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrical deep endometriosis that may help inspire additional studies in the future.
Three-Dimensional Measurement of Face as a Novel Distinguishing Tool in Facioscapulohumeral Muscular Dystrophy
Authors: HANGUL Ceren , ÖZSOY Umut , HİZAY Arzu , KARAUZUM Sibel BERKER , FIRAT Mehmet Ziya , UYSAL Hilmi , SAUER Elizabeta 
Published: January 2024

Abstract

Background
Facioscapulohumeral dystrophy (FSHD) almost always affects the muscles of the face. Quantiative evalution of face is essential for the identification of severity in the facial region. The aim of this study is to evaluate facial involvement of FSHD patients with three-dimensional(3D) scanning to answer these questions: (Q1) Are the facial 3D evaluations of FSHD patients different compared to healthy individuals? (Q2) Do 3D evaluations correlate with genetic mutation and clinical severity of the disease?
Methods
The 3D facial scanning was performed in three axes coordinate system. Outcome variables were intensity and asymmetry estimations of those facial expressions; eyebrow elevation, maximal closing of the eyes, maximal showing of the teeth, whistling, and happy. Genetic diagnosis was performed with southern blot analysis to reveal D4Z4 repeat contraction on 4q35 (D4Z4-RU). Clinical severity score (CSS) was determined via neurological examination. For Q1, intensity and asymmetry related 3D variables were compared between the control and FSHD groups. For Q2, the correlation analysis was performed between intensity related 3D variables and genetic mutation and clinical severity. The level of significance had been set to p ≤ 0. 05.
Results
Twenty-one healthy controls (57.1% female) and 12 FSHD patients (58.3% female) were included. Significantly different (p < 0.002 and < 0.001) facial expressions were; the intensity of whistling, maximal closing of the eyes and happy expressions. There was no significant difference in asymmetry related measurements. No correlation between facial variables with D4Z4-RU and CSS was detected.
Conclusions
The 3D method can be used as a quantitative evaluation method in diseases manifested by impaired mimic muscle functions such as FSHD.
Modeling the Elastic Collision of Nanoparticle with Erytrocite: Viscoelastic Effects on Angular Dispersion
Authors: Rivera Ángela Johana Riaño , Barrantes Laura María Roa , Rodriguez Diego Julian 
Published: January 2024

Abstract

To achieve effective drug administration and minimize toxicity, it is crucial to predict the movement and trajectory of nanoparticles, or other nanodevices, when they interact with blood components. In this study, a dispersion model was developed for the interaction between a nanoparticle (NP) and a red blood cell (RBC) considering an elastic collision, assuming that RBCs are the main scattering center in drug delivery through the bloodstream. To analyze the model, the viscoelastic characteristics of the RBC membrane were highlighted, which allowed for the study of interaction in the collision interval through classical molecular dynamics. The kinetic and energetic behavior of the interaction was described, taking into account the drag force exerted by the RBC surface on the nanoparticle and the viscoelastic force that causes a non-linear displacement of the nanoparticle. Additionally, an analytical model based on the trajectory vectors before and after collision, associated with the position and velocity vectors of the nanoparticle, was proposed. This allowed for obtaining the angular dispersion profiles and quantifying the differential effective collision section between the particle and the RBC. The results showed that dispersion depends on the biconcave and symmetrical geometry of the RBC, as well as the velocity and direction of the nanoparticle movement.
Proposal for a Protocol for Adaptation of the Oral Environment Prior to Major Surgery: A Series of Cases.
Authors: COSTA RAQUEL COELHO NETTO DA , Feitosa Telcilene Martins , de Sousa Franklin Monteiro , FERREIRA MEIRE COELHO 
Published: January 2024

Abstract
The intensive involvement of the dentistry team as a multidisciplinary strategy in the preoperative period showed an accelerated recovery of patients undergoing oncological surgery. Protocols were adopted that included oral preparation before surgery, which brought good results in the postoperative period for these patients. However, perioperative oral practices as a protective factor have not yet been well understood and need to be further studied.
OBJECTIVE: to present a medical-surgical care protocol for patients, with adaptation of the oral environment prior to major orthopedic surgeries, specifically hip arthroplasty, in a university hospital. SAMPLE: 23 patients who underwent an outpatient consultation with the orthopedic surgeon and were referred to the hospital's dentistry service to adapt the oral environment prior to hip arthroplasty surgery.
MATERIAL AND METHOD: Case series study in which the hospital records of 23 patients were evaluated to investigate the main postoperative complications found in a group where 100% of patients underwent previous mouth preparation. For this purpose, dental records were collected with patient data such as the patient's medical record number, odontogram and report on the execution of the dental procedures performed. Two years after the adoption of this system, the patients' medical records were coded and analyzed by a researcher who, using the hospital's computer system, verified the length of stay for each patient, the execution of the procedure in the surgical center and the main reports of complications in each patient. patient such as postoperative infection, pneumonia, admission to an intensive care unit as well as the hospital discharge report.
RESULTS: We observed that 100% of patients who underwent previous mouth preparation, none contracted pneumonia; There were no reports of dental loss or trauma during intubation or throughout the hospitalization period; The average length of stay was 9 days; There was one admission to the intensive care unit with a history of sepsis, cardiac arrest and subsequent death; Among the most reported postoperative complications, in addition to pain, we found volunteers with infection at the surgical site and two volunteers with deep vein thrombosis; 15 volunteers were discharged from hospital.