bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Numerical Investigation of the Seismic Performance of RC Moment Resisting Frames
Authors: Esfandiari Javad , Roudsari Mehrzad Tahmouli , Esfandiari Soheil 
Published: February 2024

The rehabilitation of concrete structures has been a subject of extensive investigation, exploring various facets. One such avenue involves the incorporation of fiber additives into concrete materials. In parallel, the construction of reinforced concrete structures inevitably encounters construction errors, necessitating constant efforts from researchers to devise solutions for mitigating their impact. In the context of this research, a series of experiments was conducted involving the construction and testing of five reinforced concrete moment-resisting frames. The initial sample served as the control, while two additional samples were integrated with polypropylene and metal fibers. The subsequent two samples deliberately introduced a manufacturing error through the application of air-entraining admixture materials at the beam-to-column connection. This deliberate error aimed to assess the influence of additive fibers on frames affected by manufacturing errors. Several critical parameters were subjected to evaluation, including ultimate strength, stiffness, ductility, energy dissipation capacity, and strength reduction factor. The results of these assessments demonstrated that the utilization of additive fibers contributes to an enhanced overall performance of the frames, as inferred from the aforementioned seismic parameters. Furthermore, it was established that the incorporation of these additive fibers substantially alleviates the impact of manufacturing errors on moment-resisting reinforced concrete frames. Although a significant reduction in energy dissipation capacity was observed in samples with manufacturing errors, the other seismic parameters remained relatively unaffected. Subsequently, numerical models were generated in ABAQUS software to validate the experimental findings, and their outcomes were compared with the results derived from the physical experiments.
Pendampingan Digitalisasi UMKM Binaan Di Kelurahan Sendangtirto, Berbah, Sleman Diy
Authors: Indani Farinza Tiara , Wahyuningsih Adityas , Andriani Juwita , Arifah Amalina Nur , Sulistyowati Andita 
Published: February 2024

MSMEs in Indonesia are a potential basis for a strong national economy because of their large number, especially micro businesses, and their labor absorption capacity is very large. Sendangtirto Village, which is part of the Berbah District Area, Sleman Regency, DIY, also has quite large MSME potential. By knowing and mapping the potential of MSMEs in Sendangtirto and assisting by providing training outreach and mentoring on the digitalization of Sendangtirto MSMEs, it is hoped that it will advance and be able to develop MSMEs, increasing competitiveness with the integration of digital platforms. This service function aims to apply and disseminate the knowledge and skills possessed by academics to the wider community, as well as contributing directly to improving the quality of life and sustainable development. The results of data analysis from the questionnaire showed a significant increase in participants' understanding after the socialization. The participants' positive response to the benefits and ease of use of digital platform robots for ease in digitalizing MSMEs illustrates the success of this socialization. Keywords: digitalization; socialization;potential of MSMEs
Chemical profiling of volatile compounds of the essential oil of grey-leaved rockrose (Cistus albidus L.) and its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer activity in vitro and in silico
Authors: Elbouzidi Amine , Taibi Mohamed , Laaraj Salah , Loukili El Hassania , Haddou Mounir , El Hachlafi Naoufal , Naceiri Mrabti Hanae , Baraich Abdellah , Bellaouchi Reda , Asehraou Abdeslam , Bourhia Mohammed , Nafidi Hiba-Allah , Bin Jardan Yousef A. , Chaabane Khalid , Addi Mohamed 
Published: February 2024

Cistus albidus: L., also known as Grey-leaved rockrose and locally addressed as šṭab or tûzzâla lbîḍa, is a plant species with a well-established reputation for its health-promoting properties and traditional use for the treatment of various diseases. This research delves into exploring the essential oil extracted from the aerial components of Cistus albidus (referred to as CAEO), aiming to comprehend its properties concerning antioxidation, anti-inflammation, antimicrobial efficacy, and cytotoxicity. Firstly, a comprehensive analysis of CAEO’s chemical composition was performed through Gas Chromatography-Mass Spectrometry (GC-MS). Subsequently, four complementary assays were conducted to assess its antioxidant potential, including DPPH scavenging, β-carotene bleaching, ABTS scavenging, and total antioxidant capacity assays. The investigation delved into the anti-inflammatory properties via the 5-lipoxygenase assay and the antimicrobial effects of CAEO against various bacterial and fungal strains. Additionally, the research investigated the cytotoxic effects of CAEO on two human breast cancer subtypes, namely, MCF-7 and MDA-MB-231. Chemical analysis revealed camphene as the major compound, comprising 39.21% of the composition, followed by α-pinene (19.01%), bornyl acetate (18.32%), tricyclene (6.86%), and melonal (5.44%). Notably, CAEO exhibited robust antioxidant activity, as demonstrated by the low IC50 values in DPPH (153.92 ± 4.30 μg/mL) and β-carotene (95.25 ± 3.75 μg/mL) assays, indicating its ability to counteract oxidative damage. The ABTS assay and the total antioxidant capacity assay also confirmed the potent antioxidant potential with IC50 values of 120.51 ± 3.33 TE μmol/mL and 458.25 ± 3.67 µg AAE/mg, respectively. In terms of anti-inflammatory activity, CAEO displayed a substantial lipoxygenase inhibition at 0.5 mg/mL. Its antimicrobial properties were broad-spectrum, although some resistance was observed in the case of Escherichia coli and Staphylococcus aureus. CAEO exhibited significant dose-dependent inhibitory effects on tumor cell lines in vitro. Additionally, computational analyses were carried out to appraise the physicochemical characteristics, drug-likeness, and pharmacokinetic properties of CAEO’s constituent molecules, while the toxicity was assessed using the Protox II web server.
Case Report: Resuscitation of patient with tumor-induced acute pulmonary embolism by venoarterial extracorporeal membrane oxygenation
Authors: Zhang Shuang-Long , Zhang Qi-Feng , Li Gang , Guo Miao , Qi Xiao-Xia , Xing Xiao-Hui , Wang Zheng 
Published: February 2024

BackgroundPulmonary embolism is a condition of right cardiac dysfunction due to pulmonary circulation obstruction. Malignant tumor-induced pulmonary embolism, which has a poor therapeutic outcome and a significant impact on hemodynamics, is the cause of sudden death in patients with malignant tumors.Case descriptionA 38-year-old female patient, who had a medical history of right renal hamartoma, and right renal space-occupying lesion, was admitted to the hospital. During the procedure to resect the right renal malignancy, the blood pressure and end-tidal carbon dioxide level dropped, and a potential pulmonary embolism was considered as a possibility. After inferior vena cava embolectomy, the hemodynamics in the patient remained unstable. The successful establishment of venoarterial extracorporeal membrane oxygenation (VA-ECMO) resulted in the stabilization of her hemodynamics and ventilation. On Day 2 of VA-ECMO support, her respiration and hemodynamics were relatively stable, and ECMO assistance was successfully terminated following the “pump-controlled retrograde trial off (PCRTO)” test on Day 6. The patient improved gradually after the procedure and was discharged from the hospital after 22 days.ConclusionVA-ECMO can be used as a transitional resuscitation technique for patients with massive pulmonary embolism. It is critical for the perfusion of vital organs and can assist with surgical or interventional treatment, lower right heart pressure, and hemodynamic stability. VA-ECMO has a significant impact on patient prognosis and can reduce the mortality rate.
Patient-centered evaluation of an expectation-focused intervention for patients undergoing heart valve surgery: a qualitative study
Authors: Clifford Caroline , Girdauskas Evaldas , Klotz Susanne G. R. , Kurz Saskia , Löwe Bernd , Kohlmann Sebastian 
Published: February 2024

ObjectiveRandomized controlled trials demonstrate the effectiveness of expectation-focused interventions in improving recovery outcomes following cardiac surgery. For dissemination in routine health care, it is important to capture the perspective of affected individuals. This qualitative study explores the perceived benefits and intervention-specific needs of patients who received expectation-focused intervention in the context of heart valve surgery. In addition, it explores potential barriers and adverse effects.MethodsAs part of an Enhanced Recovery After Surgery (ERAS) program within a multicentered randomized controlled trial, patients undergoing minimally invasive heart valve surgery received an intervention focused on their expectations. Six weeks after the intervention, semi-structured interviews were conducted with 18 patients to assess its feasibility, acceptance, barriers, benefits, and side effects. The transcribed interviews were analyzed using qualitative content analysis.ResultsThe results indicate that both the intervention and the role of the patient and psychologist are key aspects in evaluating the expectation-focused intervention. Five key themes emerged from the patients’ perspective: personal needs, expectations and emotions, relationship, communication, and individuality. Patients valued the preparation for surgery and recovery and the space for emotions. Establishing a trustful relationship and addressing stigmatization were identified as primary challenges within the intervention.ConclusionOverall, patients experienced the expectation-focused intervention as helpful and no adverse effects were reported. Perceived benefits included enhanced personal control throughout the surgery and recovery, while the potential barrier of stigmatization towards a psychologist may complicate establishing a trustful relationship. Addressing personal needs, as a relevant topic to the patients, could be achieved through additional research to identify the specific needs of different patient subgroups. Enhancing the expectation-focused intervention could involve the implementation of a modular concept to address individual needs better.
Hyperbaric oxygen effectively addresses the pathophysiology of long COVID: clinical review
Authors: Katz Alan A. , Wainwright Sandra , Kelly Matthew P. , Albert Pradeep , Byrne Rosemary 
Published: February 2024

BackgroundThe World Health Organization defines long COVID as “the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation.” Estimations of approximately 50 million individuals suffer from long COVID, reporting low health-related quality of life. Patients develop ongoing persistent symptoms that continue for more than 12 weeks that are not explained by another alternative diagnosis. To date, no current therapeutics are effective in treating the underlying pathophysiology of long COVID.DiscussionA comprehensive literature search using PubMed and Google Scholar was conducted and all available articles from November 2021 to January 2024 containing keywords long covid and hyperbaric oxygen were reviewed. These published studies, including case series and randomized trials, demonstrate that utilizing Hyperbaric Oxygen Therapy (HBO) provided significant improvement in patients with long COVID.ConclusionA large cohort of patients suffer from long COVID or post-COVID-19 syndrome after recovery from their acute infection with no effective treatment options. HBO is a safe treatment and may provide benefit for this population and should continue to be researched for adjunctive treatment of long COVID.
Temporal changes in ewe vaginal microbiota throughout gestation
Authors: Cassas Mackenzie S. , Jonas Lucille C. , Anderson Chiron J. , Schmitz-Esser Stephan , Youngs Curtis R. 
Published: February 2024

IntroductionNumerous factors are known to influence reproductive efficiency in ewes, but few studies have investigated the potential role of vaginal microbiota in sheep reproductive success. The objective of this study was to thoroughly characterize the ewe vaginal microbiota throughout the course of pregnancy.MethodsVaginal samples were collected from 31 pregnant Hampshire and Hampshire X Suffolk crossbred ewes on a weekly basis from pre-breeding to pregnancy testing and then biweekly until just after lambing. To characterize the vaginal microbial communities, DNA was extracted and 16S rRNA gene Illumina MiSeq amplicon sequencing was performed.Results and DiscussionAlpha diversity metrics indicated an increase in species richness, evenness, and overall diversity throughout gestation. Distinct shifts in the bacterial communities were observed during gestation and were segregated into three periods: early gestation, a transitional period and mid/late gestation. During early gestation, Actinobacillus, Histophilus, and unclassified Leptotrichiaceae were found in greater relative abundance. During the transitional period, a population shift occurred characterized by increasing relative abundance of Streptococcus and Staphylococcus. During mid/late gestation, Staphylococcus, Streptococcus, and Ureaplasma had the greatest relative abundance. These shifts in the microbial population throughout the ewe’s gestation are likely related to hormonal changes triggered by the growing conceptus, specifically increasing blood concentration of progesterone. The transitional period shift in vaginal microbial communities potentially aligns with the placental take-over of progesterone production from the corpus luteum at approximately day 50 after conception (gestational week 7). Understanding the observed variability of the vaginal microbiota throughout pregnancy will allow for future comparison of ewes that did not become pregnant or had abnormal pregnancies, which could lead to the discovery of potential bacterial biomarkers for pregnancy outcome; this understanding could also lead to development of probiotics to improve sheep reproductive success.
Glycine is a transmitter in the human and chimpanzee cochlear nuclei
Authors: Baizer Joan S. , Sherwood Chet C. , Hof Patrick R. , Baker James F. , Witelson Sandra F. 
Published: February 2024

IntroductionAuditory information is relayed from the cochlea via the eighth cranial nerve to the dorsal and ventral cochlear nuclei (DCN, VCN). The organization, neurochemistry and circuitry of the cochlear nuclei (CN) have been studied in many species. It is well-established that glycine is an inhibitory transmitter in the CN of rodents and cats, with glycinergic cells in the DCN and VCN. There are, however, major differences in the laminar and cellular organization of the DCN between humans (and other primates) and rodents and cats. We therefore asked whether there might also be differences in glycinergic neurotransmission in the CN.MethodsWe studied brainstem sections from humans, chimpanzees, and cats. We used antibodies to glycine receptors (GLYR) to identify neurons receiving glycinergic input, and antibodies to the neuronal glycine transporter (GLYT2) to immunolabel glycinergic axons and terminals. We also examined archival sections immunostained for calretinin (CR) and nonphosphorylated neurofilament protein (NPNFP) to try to locate the octopus cell area (OCA), a region in the VCN that rodents has minimal glycinergic input.ResultsIn humans and chimpanzees we found widespread immunolabel for glycine receptors in DCN and in the posterior (PVCN) and anterior (AVCN) divisions of the VCN. We found a parallel distribution of GLYT2-immunolabeled fibers and puncta. The data also suggest that, as in rodents, a region containing octopus cells in cats, humans and chimpanzees has little glycinergic input.DiscussionOur results show that glycine is a major transmitter in the human and chimpanzee CN, despite the species differences in DCN organization. The sources of the glycinergic input to the CN in humans and chimpanzees are not known.
The relationship between migraine and Hashimoto’s thyroiditis: a single center experience
Authors: Nowaczewska Magdalena , Straburzyński Marcin , Meder Grzegorz , Waliszewska-Prosół Marta 
Published: February 2024

IntroductionHashimoto’s thyroiditis (HT) is nowadays the leading cause of hypothyroidism with high and still growing prevalence in general population, but there are lack of data regarding migraine and HT connection.MethodsThe aim of this study was to analyze the prevalence of HT in migraine and to check if the presence of HT influence migraine severity. This retrospective observational cohort study involved consecutive migraine patients consulted at our Headache Center with diagnosis of migraine. Electronic charts of patients were collected, including data on migraine type, presence of cranial autonomic symptoms (CAS), monthly migraine days (MMD), medication overuse headache (MOH), and the presence of comorbidities including HT.ResultsWe found 928 eligible migraine patients, 88.7% were women. The mean age was 36.09 years. 592 (63.8%) were diagnosed with episodic migraine (EM), the rest with chronic migraine (CM). MOH was additionally diagnosed in 258 (27.8%) patients. The duration of migraine was 15.99 years. 106 (11.4%) was diagnosed with HT, 148 (15.9%) with hypothyroidisms, while 84 (9.05%) had both diagnosis. Migraine patients with HT were significantly older (p &lt; 0.001), were more frequently women (p = 0.0017), had longer duration of migraine (p &lt; 0.001), had CAS more frequently (&lt;0.001), developed CM (p = 0.0169) and depression more frequently (p = 0.0047) and had more MMD (p = 0.0195) as compared with individuals without HT. According to our multivariate logistic model, the presence CM was positively associated with HT (OR 1.76, p = 0.045), MOH and duration of migraine, while negatively associated with aura.ConclusionHT is very prevalent in migraine patients. This is the first study considering migraine and HT to be comorbid and suggesting that HT may influence the course of migraine causing its chronification.
A voxel-level resting-state fMRI study on patients with alcohol use disorders based on a power spectrum slope analysis method
Authors: Ruan Xia , Song Zhiyan , Yu Tingting , Chen Jun 
Published: February 2024

BackgroundEarlier neuroimaging investigations showed that abnormal brain activity in patients with alcohol use disorder (AUD) was frequency dependent. However, there is lacking of a comprehensive method to capture the amplitude of multi-frequency bands directly. Here, we used a new method, the power spectrum slope (PSS) to explore abnormal spontaneous activity of brain in patients with AUD.MethodsThirty-three AUD patients and 29 healthy controls (HCs) enrolled in this study. The coefficient b and the power-law slope b’ were calculated and compared between two groups. We also used the receiver operating characteristic (ROC) curve to examine the ability of the PSS analysis to distinguish between AUD and HCs. We next examined the correlation between PSS difference in the brain areas and the severity of alcohol dependence.ResultsThirty AUD patients and 26 HCs were retained after head motion correction. The two metrics of PSS values increased in the left precentral gyrus in AUD patients. The area under the curve values of PSS differences in the specific brain area were respectively 0.836 and 0.844, with sensitivities of 86.7% and 83.3% and specificities of 73.1% and 76.9%. The Michigan Alcoholism Screening Test (MAST) and Alcohol drinking scale (ADS) scores were not significantly correlated with the PSS values in the specific brain area.ConclusionAs a novel method, the PSS can well detect abnormal local brain activity in the AUD patients and may offer new insights for future fMRI studies.
Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China
Authors: Xu Jinxin , Hong Zhinuan , Cai Yingjie , Chen Zhen , Lin Jingping , Yuan Xi , Chen Shuchen , Xie Jinbiao , Kang Mingqiang , Ke Sunkui 
Published: February 2024

ObjectiveThis study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy.MethodsA total of 190 LA-ESCC patients were recruited from three medical centers across China. Pre-treatment laboratory tests were utilized to calculate inflammatory nutritional scores. LASSO regression and multivariate logistic regression analyses were conducted to pinpoint predictors of pathological response. Kaplan-Meier and Cox regression analyses were employed to assess disease-free survival (DFS) prognostic factors.ResultsThe cohort comprised 154 males (81.05%) and 36 females (18.95%), with a median age of 61.4 years. Pathological complete response (pCR) was achieved in 17.38% of patients, while 44.78% attained major pathological response (MPR). LASSO and multivariate logistic regression analyses identified that hemoglobin, albumin, lymphocyte, and platelet (HALP) (P=0.02) as an independent predictors of MPR in LA-ESCC patients receiving neoadjuvant chemoimmunotherapy. Kaplan-Meier and log-rank tests indicated that patients with low HALP, MPR, ypT1-2, ypN0 and, ypTNM I stages had prolonged DFS (P &lt; 0.05). Furthermore, univariate and multivariate Cox regression analyses underscored HALP (P = 0.019) and ypT (P = 0.029) as independent predictive factors for DFS in ESCC.ConclusionOur study suggests that LA-ESCC patients with lower pre-treatment HALP scores exhibit improved pathological response and reduced recurrence rate. As a comprehensive index of inflammatory nutritional status, pre-treatment HALP may be a reliable prognostic marker in ESCC patients undergoing neoadjuvant chemoimmunotherapy.