bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geeks versus climate change: Understanding American video gamers’ engagement with global warming
Authors: Carman Jennifer P. , Psaros Marina , Rosenthal Seth A. , Marlon Jennifer , Verner Marija , Lee Sanguk , Lu Danning , Goldberg Matthew H. , Ballew Matthew , Leiserowitz Anthony 
Published: February 2024

Abstract

As climate change impacts increase, communicators must engage as many audiences as possible in climate action. One potentially underrated audience is video gamers. Two-thirds of Americans play video games, and video games are a potentially effective climate change communication tool. However, little research has examined whether video gamers have unique value as a target audience for climate communication, and if they do, what might be effective ways to reach them. To address this need, we use two surveys including self-identified video game players in the United States to measure their current engagement with climate change, including through video gaming. In Study 1, a nationally representative survey in the United States (N = 1,006), we found that being a video gamer was slightly positively associated with intentions to take collective action on global warming. In Study 2, restricted to gamers in the United States (N = 2,034), we found that having more friends and family who played video games, and/or being exposed to global warming content in gaming, were also positively associated with collective action intentions. These findings were consistent even after controlling for potential confounding variables such as age, political party, and global warming attitudes. Results suggest that video gamers are a worthwhile potential audience for future climate change communication, combatting the stereotype of video gamers as disengaged or antisocial, at least in the context of climate change. Our study also identifies several potential avenues for future communication with video gamers, particularly outreach to and engagement with gaming communities.
Electronic Band Alignment of Aqueous Zinc Anode &amp; Favorable Chalcogenide Cathode- Cu2NiSnS4 (CNTS) Battery and its Performance Analysis
Authors: NILEGAVE DHANARAJ S. , Shaikh Gulistan Y. , Girawale Swapnil , Chaturvedi Smita , Jadhav Vijay 
Published: February 2024

Abstract
Aqueous zinc-ion batteries are one of the most efficient and promising energy storage devices due to immense amount advantages such as non-toxicity, safety, cost-effectiveness, and earth abundance. However, zinc metal has the redox potential of -0.76V which is comparable and suitable for aqueous systems as an anode. Herein, quaternary chalcogenide wurtzite Cu2NiSnS4 (CNTS) has been demonstrated as a stable electrode material for aqueous Zinc-ion battery pouch cell with high capacity and the potential of 1.34V. The band alignment of the Zn/CNTS also has been studied by the combined comparison of the optical band gap of CNTS and cyclic voltammetry curve analysis. CNTS delivers the specific capacity of 261mAh/g at the current density of 62.5mAh/g and good cycle performance in Zn/CNTS pouch cells. The striking electrochemical properties are ascribed to the excellent stability of CNTS while galvanostatic cycling, in which the cation Zn2+ can be intercalated/deintercalated at the chalcogenide cathode CNTS. The intercalation results in the formation of ZnS while cycling which has been analyzed by Raman spectra after the cycling of pouch cell. The mechanism study discloses the reversible shuttling of Zn2+cations into/from CNTS.
Accumulated experience of preying on escaping bait enhances pursuit performance in mice
Authors: Wang Jincheng , Zhang Yueting , Lv Songyan , Pang Ruiqi , Zhang Yanjie , Liu Xue , Deng Qiyue , Zhou Yi 
Published: February 2024

Abstract

As a highly sequentially programmed behavior driven by innate desire, one of the most challenging parts of preying is how the hunter can pursue and capture an escaping prey that is also running for its own survival. Although presumed, it remains uncertain how the experience of competing with escaping prey can enhance preying performance. Here, we developed an interactive platform to study the preying behavior in mice using an escaping bait. This robotic bait was magnetically controlled by a closed-loop system that continuously attempted to evade an approaching threat (e.g., a hungry mouse). By recording the time costs, trajectories and other parameters of both mouse and the escaping bait, we found that mice were not only able to perform preying tasks of varying difficulties, but also that they could improve their preying efficiency over trials, mainly due to the improvements in the pursuit phase. Further investigation revealed that the enhancement in pursuit performance primarily resulted from changes in pursuit strategy and the optimization of velocity control. In conclusion, this study reveals that experienced mice can optimize their pursuit strategies to improve their preying efficiency, and the transition from novice to veteran can be used to study the biological mechanisms of behavioral flexibility in mice.
The Combination of Two Conspiracy-Belief-Scales and a correlational analysis with Epistemic Beliefs
Authors: Hollitzer Peter , Daseking Monika , Ibrahim Fabio 
Published: February 2024

Abstract

Conspiracy belief (CB) describes the extent to which the individual believes a conspiracy narrative. Conspiracy narratives represent anti-empirical theories according to which a minority has secretly come together to pursue sometimes vile goals with sometimes vile means. Over the last decade the scientific interest in CBs increased which led to many different scales to assess CBs. Often CB is measured using the acceptance of different conspiracy theories (CTs) expressed on a dichotomous or Likert scale. The aim of this study is to test the psychometric quality of two of the few validated scales for measuring CB in German-speaking countries and to maximise the validity of the questionnaires based on a test theory. A sample of N = 254 was recruited for this purpose. As a factorial analysis based on the classical test theory showed insufficient results, the item response theory and a graphical item threshold analysis was conducted indicated a dichotomous scale as most informative. As both the GVT-12 scale (Neumann, 2010) and the subscale real CT of van Prooijen et al. (2018) measured the acceptance of real CTs they were merged and jointly examined. The successive exclusion of items with unacceptable fit resulted in two scales, one for real CB and one for fictional CB, which only comprised van Prooijen´s items. As factor analysis was conducted to test the convergence of both scales. The results indicated a two-factorial model as best fitting. However, future studies should investigate a possible bifactorial structure. Moreover, the construct validity of both subscales was assessed through their correlation with epistemological beliefs, supporting the discriminant validity between fictional and real CB.
Analytical Approach to Investigate the Effects of Through-Thickness Stress on Springback in Bending of Isotropic Sheet Metal
Authors: Movahedi Mohammad Reza , Gerdooei Mahdi 
Published: February 2024

Abstract

Within contemporary sheet metal forming processes like electromagnetic forming, the sheet experiences pronounced out-of-plane compression stress. This study focuses on the predicting the springback in the bending of an isotropic sheet metal in the presence of through-thickness compressive normal stress. In the analytical method, the longitudinal stress distribution across sheet thickness was calculated via equilibrium equations and the associated flow rule in incremental plasticity based on the power law hardening model, obtaining the reverse bending moment. During the unloading phase, the external load was lifted, and the springback angle was estimated by assuming linear elastic behavior and neglecting the Bauschinger effect, employing the superposition method. A case study was conducted on an aluminum alloy sheet for different compressive stresses and bend curvatures. Subsequently, the reverse bending moments and springback angles obtained for each case were compared to the numerical outcomes from finite element (FE) modeling. Analytical results indicate that elevating the compressive normal stress on the sheet surface to 75% and 100% of the yield stress will lead to a reduction in springback by 17.4% and 32%, respectively. At the compressive normal stress of 75% of the yield stress, the numerical model exhibited a 4.4% difference from the analytical model. For the validation of the analytical model, a four-point bending test was conducted with varying initial bend curvatures and angles. This involved comparing the experimental springback angle and curvature with both numerical and analytical predictions. In comparison, both the numerical and analytical models demonstrated strong agreement with the experimental results.
Removal of Endothelial Surface-associated Von Villebrand Factor Suppresses Accelerate Datherosclerosis After Myocardial Infarction
Authors: Ozawa Koya , Packwood William , Qi Yue , Muller Matthew , Xie Aris , Varlamov Oleg , McCarty Owen , Chung Dominic , Lopez Jose , Lindner Jonathan 
Published: February 2024

Abstract

Background Thromboinflammation involving platelet adhesion to endothelial surface-associated von Willebrand factor (VWF) has been implicated in the accelerated progression of non-culprit plaques after MI. The aim of this study was to use arterial endothelial molecular imaging to mechanistically evaluate endothelial-associated VWF as a therapeutic target for reducing remote plaque activation after myocardial infarction (MI).Methods Hyperlipidemic mice deficient for the low-density lipoprotein receptor and Apobec-1 underwent closed-chest MI and were treated chronically with either: (i) recombinant ADAMTS13 which is responsible for proteolytic removal of VWF from the endothelial surface, (ii) N-acetylcysteine (NAC) which removes VWF by disulfide bond reduction, (iii) function-blocking anti-factor XI (FXI) antibody, or (iv) no therapy. Non-ischemic controls were also studied. At day 3 and 21, ultrasound molecular imaging was performed with probes targeted to endothelial-associated VWF A1-domain, platelet GPIbα, P-selectin and vascular cell adhesion molecule-1 (VCAM-1) at lesion-prone sites of the aorta. Histology was performed at day 21.Results Aortic signal for P-selectin, VCAM-1, VWF, and platelet-GPIbα were all increased several-fold (p < 0.01) in post-MI mice versus sham-treated animals at day 3 and 21. Treatment with NAC and ADAMTS13 significantly attenuated the post-MI increase for all four molecular targets by > 50% (p < 0.05 vs non-treated at day 3 and 21). On aortic root histology, mice undergoing MI versus controls had 2–4 fold greater plaque size and macrophage content (p < 0.05), approximately 20-fold greater platelet adhesion (p < 0.05), and increased staining for markers of platelet transforming growth factor-β1 signaling. Accelerated plaque growth and inflammatory activation was almost entirely prevented by ADAMTS13 and NAC. Inhibition of FXI had no significant effect on molecular imaging signal or plaque morphology.Conclusions Plaque inflammatory activation in remote arteries after MI is strongly influenced by VWF-mediated platelet adhesion to the endothelium. These findings support investigation into new secondary preventive therapies for reducing non-culprit artery events after MI.
Construction of a prediction model for Non-tuberculous mycobacterial lung disease based on clinical characteristics and analysis of its application value
Authors: Liu Haiqing , Han Mingfeng , Cheng Guoling , Yan Hao , Hou Jing , Cao Xiaoyu , Zhang Wei 
Published: February 2024

Abstract

Objective
The objective of this study was to explore the differential clinical features between Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB), and to develop a predictive model for the differential diagNosis of these two conditions. The study aimed to provide clinical guidance for the diagNosis and treatment of NTM-PD.
Methods
The study included 145 patients with NTM-PD and 206 patients with PTB, whose clinical characteristics,imaging findings,and inflammatory markers were compared.A binary logistic regression model was used to analyze the influencing factors and evaluate the predictive performance and calibration accuracy of the model.
Results
A comparative analysis of clinical, imaging, and inflammatory markers between NTM-PD and PTB groups revealed significant differences in demographics (age, gender, occupation, BMI), symptoms (dyspnea, loss of appetite, fever), risk factors (smoking, alcohol consumption history, diabetes), and comorbidities (bronchiectasis, emphysema, COPD, cystic-columnar, honeycomb, lung cavitation, MONo%; P < 0.05). Multivariate binary logistic regression identified gender and diabetes as protective, while bronchiectasis, COPD, and lung cavitation as risk factors. The model's predictive performance was strong with an AUC of 0.874 (95% CI 0.837 ~ 0.910; P < 0.001) and a Youden index of 0.611, yielding sensitivity of 83.4% and specificity of 77.7%. Model calibration was assessed by the Hosmer-Lemeshow test, showing no significant difference between predicted and observed values (χ²=7.895, P = 0.444 > 0.05).
Conclusion
In female patients without diabetes or underlying conditions such as bronchiectasis or COPD, when high-resolution computed tomography (HRCT) of the chest reveals predominantly cavitated lesions, it is imperative to give high priority to the differential diagnosis for possible NTM-PD, given its clinical resemblance to PTB. A meticulous distinction between these diagnoses is essential during the diagnostic process to prevent misdiagnosis.
Exploring the effect of hepatitis B e antigen on neutrophil activation and natural killer cell dysfunction in patients with chronic hepatitis B
Authors: Feng Zhiqian , Fu Junliang , Tang Lili , Bao Chunmei , Liu Honghong , Liu Kai , Yang Tao , Yuan Jin-Hong , Zhou Chun-Bao , Zhang Chao , Xu Ruo-nan , Wang Fu-Sheng 
Published: February 2024

Abstract
Background
The role of neutrophils in hepatitis B virus (HBV) infection has been a subject of debate due to their involvement in antiviral responses and immune regulation. This study aimed to elucidate the neutrophil characteristics in patients with chronic hepatitis B (CHB).
Methods
Through flow cytometry and ribonucleic acid-sequencing analysis, the phenotypes and counts of neutrophils were analyzed in patients with CHB. Moreover, the effects of HBeAg on neutrophils and the corresponding pattern recognition receptors were identified. Simultaneously, the cross-talk between neutrophils and natural killer (NK) cells was investigated.
Results
Neutrophils were activated in patients with CHB, characterized by higher expression levels of programmed death-ligand 1 (PD-L1), cluster of differentiation 86, and interleukin-8, and lower levels of CXC motif chemokine receptor (CXCR) 1 and CXCR2. Hepatitis B e antigen (HBeAg) partially induces neutrophil activation through the Toll-like receptor 2 (TLR2). A coordinated upregulation of the TLR2 and HBeAg expression was observed in patients with CHB. Notably, the genes encoding molecules pivotal for NK-cell function upon NK receptor engagement enriched in neutrophils after HBeAg activation. The HBeAg-activated neutrophils demonstrated the ability to decrease the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in NK cells, while the PD-1 and PD-L1 pathways partially mediated the immunosuppression.
Conclusions
The immunosuppression of neutrophils induced by HBeAg suggests a novel pathogenic mechanism contributing to immune tolerance in patients with CHB.
Evaluating Vonoprazan and Tegoprazan for Gastroesophageal Reflux Disease Treatment in Chinese Healthcare: An EVIDEM Framework Analysis
Authors: Xue Chaojun , Du Yuhan , Yang Haotian , Jin Huixin , Zhao Yue , Ren Bingnan , Dong Zhanjun 
Published: February 2024

Abstract

Background
In Chinese healthcare settings, decisions regarding drug selection are predominantly guided by the Pharmacy & Therapeutics Committee (PTC). This study focuses on two recently introduced potassium-competitive acid blockers in China, vonoprazan (VPZ) and tegoprazan (TPZ). The objective was to assess these drugs using the Evidence and Value: Impact on DEcisionMaking (EVIDEM) framework.
Methods
This study utilized the 10th edition of EVIDEM, comprising a core model with five domains and 13 criteria. It involved two independent expert panels. The PTC expert panel was tasked with five responsibilities: assigning weights using a 5-point scale, defining scoring indicators, examining the evidence matrix, scoring, and decision-making. The evidence matrix expert panel had three duties: conducting a systematic literature review, creating the evidence matrix, and evaluating the value contributions of VPZ and TPZ.
Results
The analysis estimated the value contributions of VPZ and TPZ at 0.59 and 0.54, respectively. The 'economic consequences of intervention' domain exhibited the most significant variation in value contribution between the two drugs, followed by 'comparative outcomes of intervention' and 'type of benefit of intervention'.
Conclusion
Utilizing the EVIDEM framework, VPZ's value contribution appears marginally superior to that of TPZ. The EVIDEM framework shows promise for application in Chinese medical institutions.
Direct Medical Costs and Medication Use Trends in Patients Having Type 2 Diabetes with Chronic Kidney Disease in Beijing, China in 2016–2018
Authors: Zhang Jie , Wang Weihao , Man Fuli , Zhang Xianbo , Wang Xiaoxia , Pan Qi , Guo Li Xin 
Published: February 2024

Abstract
Background
Types of medications used and costs of drugs for patients having type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD) have not been evaluated in outpatients in Beijing, China.
Objectives
In this study, we aimed to assess the medical costs and use of anti-diabetic therapy in patients having T2DM with CKD in Beijing.
Methods
This observational, retrospective study included diabetic patients with outpatient records in the Beijing Medical Insurance database from 2016 to 2018 and analyzed the enrolled patients’ oral hypoglycemic drug use, insulin use, non-hypoglycemic drug use, comorbidities, T2DM-related complications, treatment strategies, and annual medical costs.
Results
This study recruited 2,853,036 patients with T2DM from the Beijing Medical Insurance database. Notably, 6.87–8.18% of diabetic patients were diagnosed as having CKD. Compared with diabetic patients without CKD, those with CKD showed significantly more diabetic complications (3.32 ± 1.6 vs. 2.09 ± 1.5), more types of medications used (4.8 ± 2.63 vs. 3.75 ± 2.33), and a higher total annual drug cost ($2,017 ± $1,627 vs. $1,350 ± $1260). CKD patients used significantly more types of medications and had significantly lower drug costs in 2018 (4.8 ± 2.62 and $2,017 ± $1,627 respectively) than in 2016 (4.78 ± 2.61 and $2,323 ± $1,885, respectively).
Conclusion
As routine CKD screening is currently not protocolized in Beijing’s outpatient process, CKD prevalence in T2DM patients with medical insurance is erroneously projected to be much lower in Beijing than in other areas of China. Early screening, diagnosis, and treatment of T2DM patients may delay the progress of CKD and reduce the future economic burden on the society.
Elevated red blood cell count levels are associated with increased vascular calcifcation in hemodialysis patients
Authors: zhang fan , li guoli , yu jie , fu shuangshuang , Yang Yiya , Liang Yumei , chen yinyin , Luo Xun 
Published: February 2024

Abstract
Introduction:
Coronary artery calcification (CAC) is a predictor of poor survival and cardiovascular outcome in end-stage renal disease patients.We conducted this study to assess the risk factors for vascular calcification in maintenance hemodialysis patients.
Methods:
A total of 71 cases of HD patients who underwent hemodialysis in Hunan Provincial People's hospital from January 2022 to September 2022 were enrolled. The general clinical data and Laboratory results of the patients were collected.Chest CT examination was performed,and the CAC score was calculated.
Results:
CAC occurred in 41 ( 57.75%) of the 71 HD patients in the study.In the logistic regression analysis, CAC in these patients was significantly predicted by an diabetes (OR [95% CI]: 6.20 [1.37–28.11], P = 0.02) and red blood cell count (OR [95% CI]: 2.29 [1.05–5.02], P = 0.04).The ROC curve was applied to analyzing the red blood cell count; the area under the curve (AUC) was 0.66 (P = 0.02) and clinical diagnostic cutoff value = 2.99 (sensitivity = 75.6% and specificity = 56.7%) .
Conclusion:
The incidence rate of CAC in HD patients was high.Diabetes and red blood cell count were independent risk factors for CAC in HD patients.
Sleep disturbance and internalizing symptoms in adolescents: A moderated mediation model of self-control and mindfulness
Authors: Ye Haoxian , Jiang Nan , He Sisi , Fan Fang 
Published: February 2024

Abstract

Objectives
Despite accumulating evidence regarding the impact of sleep disturbance on internalizing symptoms among adolescents, the underlying psychological mechanisms remain inadequately explored. This study aimed to investigate a conceptual framework elucidating how sleep disturbance influences internalizing symptoms in adolescents through the mediating role of self-control, with mindfulness as a moderator.
Methods
A total of 1876 Chinese adolescents provided data on sleep-related variables, internalizing symptoms (anxiety and depression), mindfulness, and self-control. Utilizing the Process macro for SPSS, a moderated mediation model was analyzed, positing that sleep disturbance would positively relate to internalizing symptoms, with self-control acting as a mediator and mindfulness as a moderator.
Results
Sleep disturbance demonstrated a significant positive correlation with internalizing symptoms in adolescents, and self-control emerged as a mediating factor in this relationship. Furthermore, mindfulness moderated the pathways from self-control to internalizing symptoms, while the mediating relationships were weaker for adolescents exhibiting higher levels of mindfulness.
Conclusions
This study highlights the crucial role of self-control as a mediator in the relationship between sleep disturbance and internalizing symptoms in adolescents. Moreover, it underscores the moderating influence of mindfulness on the pathway from self-control to internalizing symptoms. These findings enhance our understanding of the impact, pathways, and influencing factors of sleep disturbance on internalizing symptoms in adolescents, which also suggest the importance of enhancing mindfulness levels in addressing self-control deficits and subsequently reducing internalizing symptoms among adolescents.
FairAC: Long-term Balancing between Accuracy and Fairness in Recommender Systems Using a Multi-Objective Deep Reinforcement Learning Framework
Authors: Gazik Mohammad Amir Rezaei , Roayaei Mehdy 
Published: February 2024

Abstract
Recommender systems suggest the users with the most appropriate and accurate recommendations by reviewing and exploring user-related information (user's preferences and interests) from the user's previous experiences. Although recommender systems have been studied by many researchers in recent years, a few of them have considered the problem of balancing fairness and accuracy in dynamic recommender systems, where the interests of users change, and new items are added over time to the list of existing items. To resolve this problem, we propose a multi-objective deep reinforcement learning framework based on the actor-critic method, called \textit{FairAC}, which considers fairness in recommender systems in a dynamic environment. We conducted extensive experiments on real-world datasets. The results show that the proposed approach provides accurate and fair recommendations and surpassing the performance of prior studies by approximately 10\% in terms of both accuracy and fairness.