bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
Authors: Mancini Rita , Ascenzi Francesca , Esposito Antonella , Bruschini Sara , Salvati Valentina , De Vitis Claudia , Ricci Giulia , Martino Simona Di , Buglioni Simonetta , Bassi Massimiliano , Venuta Federico , De Nicola Francesca , Massacci Alice , Grassucci Isabella , Pallocca Matteo , Ricci Alberto , Fanciulli Maurizio , Ciliberto Gennaro 
Published: December 2023

Abstract

Scientific literature supports the evidence that Cancer Stem Cells (CSCs) retain inside low Reactive Oxygen Species (ROS) levels and are therefore less susceptible to cell death, including ferroptosis, a type of cell death dependent on iron-driven lipid peroxidation. A collection of lung adenocarcinoma (LUAD) primary cell lines derived from malignant pleural effusions (MPEs) of patients was used to obtain 3D spheroids enriched for stem-like properties. We observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in LUAD cells when grown in 2D conditions; however, when grown in 3D condition, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and therefore protection against ferroptotic cell death. Interestingly, this phenomenon was reversed by disrupting 3D cells and growing them back in adherence, supporting the idea of CSCs plasticity, which holds that cancer cells have the dynamic ability to transition between a CSC state and a non-CSC state. Molecular analyses showed that ferroptosis resistance in 3D spheroids correlated with an increased expression of antioxidant genes and high levels of proteins involved in iron storage and export, indicating protection against oxidative stress and low availability of iron for the initiation of ferroptosis. Moreover, transcriptomic analyses highlighted a novel subset of genes commonly modulated in 3D spheroids and potentially capable of driving ferroptosis protection in LUAD CSCs, thus allowing to better understand the mechanisms of CSC-mediated drug resistance in tumors.
Analysis of ground motion intensity measures for records of the 2023 Turkey-Syria earthquake
Authors: Erazo Kalil 
Published: December 2023

Abstract
Ground motion intensity measures (GMIM) provide a quantitative metric of the strength of a ground motion with the goal of providing a mapping to the potential damaging effects induced by earthquakes. The potential correlation between GMIM and earthquake damage allows their use in earthquake engineering applications such as (pre-event) seismic hazard/risk assessment and mitigation, and (post-event) damage assessment and resources allocation for disasters response. GMIM are also used for damage prediction in the context of performance-based earthquake engineering and earthquake-resistant design. This paper presents the evaluation of GMIM using strong motion records obtained during the 2023 Turkey-Syria earthquake. The GMIM studied include peak ground acceleration, peak ground velocity, spectral accelerations, root-mean-square acceleration, Arias intensity, cumulative absolute velocity, Housner spectral intensity, and Araya-Saragoni intensity. The GMIM are evaluated at several spatial locations where ground motion records were measured during the events. Examination of the results show that some of the GMIM showed particularly high values at locations where severe damage was observed after the earthquake. It is also shown that the maximum considered earthquake (MCE) spectra was exceeded at several locations where extensive damage was observed.
Urea-based Fuel Cells on Paper with Micro-Watt Power Generationto Drive Low Power Circuits
Authors: Krishna Sai , Lal Sweta , Shrivastava Suyash , Bahubalindruni Pydi Ganga 
Published: December 2023

Abstract
This work demonstrates the application of a urea-powered paper-based fuel cell (PFC) with Hydrogen Peroxide (H2O2) as the oxidant to drive a flexible electronic circuit (ring oscillator (RO)), for the first time. Herein, the electrochemical performance of membraneless PFCs is studied by employing different non-precious electrodes, such as, Nickel-mesh, Toray carbon paper(CP) and Nickel Cobalt nanoparticles supported on reduced Graphene Oxide loaded on the CP (NiCo@rGo@CP). A single-PFC with Ni-Co@rGo@CP as electrodes delivers a peak power density (Pmax) of 55 µW cm− 2, maximum current density (Jmax) of 371 µA cm− 2 and an open-circuit voltage (OCV) of 0.7 V at 3 M urea. A membrane-based PFC assembled onto an anion exchange membrane with Ni-Co@rGo@CP electrodes, delivers a Pmax of approx 70 µW cm− 2, Jmax of ≈ 500 µA cm− 2 and an OCV of 0.7 V at 3 M urea. Subsequently, a stack of two membrane-based PFCs delivers an OCV of ≈ 1.4 V for 400 seconds. Finally, this stack is employed as a power source to drive a RO. The measured frequency and peak-to-peak voltage are 37.52 kHz and 1.04 V, respectively. This demonstration opens a window to implement self-contained flexible electronic system using PFC as power source with minimal e-waste.
Exosomal miRNA-92a Derived from Cancer-Associated Fibroblasts Promote Invasion and Metastasis in Breast Cancer by Regulating G3BP2
Authors: sheng zhimei , Wang Xuejie , Zheng Yuanhang , Duan Wanli , Dong Hao , Zhang Hongxing , Cui Meimei , zhang baogang 
Published: December 2023

Abstract
Cancer-associated Fibroblasts (CAFs) exert a tumor-promoting effect in various cancers, including breast cancer. CAFs secrete exosomes containing miRNA and proteins, influencing the tumor microenvironment. In this study, we identified CAF-derived exosomes that transport functional miR-92a from CAFs to tumor cells, thereby intensifying the aggressiveness of breast cancer. CAFs downregulate the expression of G3BP2 in breast cancer cells, and a significant elevation in miR-92a levels in CAF-derived exosomes was observed. Both in vitro and in vivo experiments demonstrate that miR-92a enhances breast cancer cell migration and invasion by directly targeting G3BP2, functioning as a tumor-promoting miRNA. We validated that the RNA-binding proteins SNRPA facilitate the transfer of CAF-derived exosomal miR-92a to breast cancer cells. The reduction of G3BP2 protein by CAF-derived exosomes releases TWIST1 into the nucleus, promoting epithelial-mesenchymal transition (EMT) and further exacerbating breast cancer progression. Moreover, CAF-derived exosomal miR-92a induces tumor invasion and metastasis in mice. Overall, our study reveals that CAF-derived exosomal miR-92a serves as a promoter in the migration and invasion of breast cancer cells by reducing G3BP2 and may represent a potential novel tumor marker for breast cancer.
Status and availability of physiotherapy in Nepal as reported from facilities and official registers
Authors: Shakya Nishchal Ratna , Shrestha Nistha , Webb Gillian , Myezwa Hellen , Karmacharya Biraj Man , Stensdotter Ann-Katrin 
Published: December 2023

Abstract
Background
Physiotherapy is a growing profession in Nepal, but there are challenges in providing equitable access and availability to physiotherapy services, particularly in underserved areas. There have been several efforts to promote physiotherapy services, however there is still a need to develop and strengthen physiotherapy and its services. Updated information and proper planning for resource allocation are important for addressing these challenges.
Objective
This study aimed to explore the status and availability of physiotherapy in Province 3 of Nepal.
Method
Data was collected through a cross-sectional survey of health facilities in the province using stratified purposive sampling. The eligible facilities were selected from the list of Department of Health Services. The survey contained closed-ended questions addressing primarily physiotherapy services in the outpatient department, human resources, charging and record-keeping systems, and accessibility. Visits to governing institutions and reviews of register data and reports were performed to obtain national physiotherapy data.
Results
The survey included 25 urban and 4 rural facilities, including hospitals and rehabilitation centres; both public (37.9%) and non-public (62.1%). Most facilities (79.3%) employed physiotherapists with bachelor's degrees. On average, there were 29.55 physiotherapy outpatients and 14.17 inpatients per day. Patient records were mainly paper based, with most (69%) using the hospital main card for patient case documentation, while others (31%) had their own physiotherapy assessment card. The majority of referrals came from doctors in different departments. The most commonly offered services were musculoskeletal, neurological, and paediatric physiotherapy. The average charge for a single visit was 311 Nepalese rupees ≈ 2.33 US$, and daily basis charging was common. Accessibility for patients with disabilities was reported as partial by 79% of outpatient departments. Two centres did not have disability-friendly settings, and only one had a disability-friendly toilet.
Conclusion
Overall, the study highlights the significant variations in physiotherapy services and the need for proper planning. The finding emphasizes the need for a proper data registry to inform resource allocation, as well as the need for monitoring services and further research on physiotherapy provision, particularly in underserved areas.
Stochastic two-scale convergence in the mean in Orlicz-Sobolev’s spaces and applications to the homogenization of an integral func- tional
Authors: Tchinda Franck , Tachago Joel Fotso , Dongho Joseph 
Published: December 2023

Abstract
In this paper, we study the stochastic homogenization for a family of functionals with convex and nonstandard growth integrands defined on Orlicz-Sobolev’s spaces. One fundamental in this topic is to extend the classical compactness results of the two-scale convergence method in the mean to this type of spaces. This problematic relies on the notion of dynamical system which is our basic tool. Mathematics Subject Classification (2010). 35B27, 35B40, 37A05, 37A55.
Orbicularis oris and buccinator as a sphincter complex of the oral fissure – re-evaluation using isolated muscle specimens.
Authors: Ishii Masuko , Kato Kota , Ichimura Koichiro , Sakai Tatsuo 
Published: December 2023

Abstract
Purpose This study aimed to clarify the structural arrangement of the orbicularis oris (OOr), the buccinator (BC), and the other perioral muscles around the modiolus. Methods The perioral muscles in seventeen faces were dissected in situ and/or in isolated muscle specimens, and their layers were reconstructed schematically upon pantomographic view of the skeleton to evaluate their actions. Results The BC was composed of three parts including upper and lower oblique parts (BC-UO, BC-LO) in its superficial layer and a middle transverse part (BC-MT) in its deep layer. The superior and inferior OOr (SOOr and IOOr, respectively) were composed of an inner marginal part (SOOr-IM, IOOr-IM) and an outer labial part (SOOr-OL, IOOr-OL) in each. The perioral muscles as a whole were arranged in three layers. The first layer, with the depressor anguli oris (DAO) connected at the modiolus with the SOOr-OL, could mainly depress and deform the upper lip, as well as move the modiolus medially, upward, or downward. The second layer, with the BC-UO and the BC-LO connected at the modiolus with the IOOr-OL, could mainly elevate and deform the lower lip, as well as move the modiolus medially or laterally. The third layer, with the BC-MT continuous with the SOOr-IM, IOOr-IM, and IOOr-OL, could bring the upper and lower lip margins nearer to close the oral fissure lightly. Conclusions The actions of the individual perioral muscles on the movement of lips were predicted to open and close the oral fissure, and widen and narrow the lip width.
Private Practitioner Characteristics and Their Potential to Contribute to Tuberculosis Management in Indonesia
Authors: Alisjahbana Bachti , Sujatmiko Budi , Afifah Nur , Dewi Nury Fitria , Lestari Bony Wiem , Hadisoemarto Panji Fortuna , McAllister Susan , Hill Philip C 
Published: December 2023

Abstract
Background
Many tuberculosis (TB) patients first seek care through the private health sector; however, most private practitioners (PPs) are not linked to the National TB Program (NTP). We aimed to map, characterize, and assess the potential contribution of PPs to the Indonesian NTP, particularly for TB diagnosis and care.
Methods
This study was conducted between August 2017 and April 2018 in Bandung city, West Java, Indonesia. Trained enumerators surveyed 30 (of 73) randomly selected community health centers (CHCs) to identify the location of private health care facilities (HCFs) and recorded service characteristics, including physician’s qualifications and practice schedules. We also asked whether the PPs were managing patients with respiratory tract infection (RTI), ordering a TB diagnosis in the past three months, or treating TB patients at the time of interview.
Results
Among the 936 practicing PPs, 27 (IQR: 12–40) were distributed widely per CHC area. We successfully interviewed 674 (72.0%) PPs, 88.1% (594/674) of whom reported managing patients with RTI symptoms. Most PPs were administered in clinics with multiple providers (78.6%; 530/674), and 21.4% (n = 144) of the PPs were administered in a single-provider clinic. A small proportion of PPs practiced in HCFs were equipped with an X-ray (10.1%) or laboratory (27.1%) facility, and 23.2% collaborated with the national health insurance system. Almost three-quarters (70.0%) practiced in an HCF with a pharmacy. A third (33.3%; 209/627) provided services after weekday office hours, and 28.3% (191/674) offered weekday and weekend clinics. Of the PPs managing RTI patients, 241 (40.6%) reported encountering TB patients, and 101 (17.0%) had TB patients under their treatment program at the time of the interview. Overall, they self-reported that 937 patients were diagnosed with TB in the past three months and that 354 TB patients were receiving treatment.
Conclusions
PPs have great potential to contribute to TB care because they are present in large numbers, are well distributed in all CHC areas, and can provide services after regular office hours. Some PPs even worked in HCFs supported by X-rays, laboratories, and pharmacies. We should seek ways to engage PPs optimally with the NTP.
Assessing the Exchange-rate pass-through to inflation in Burundi:
A RE -EXAMINATION
Authors: Irumva Ghislain 
Published: December 2023

Abstract
This study assesses the empirical determinants of inflation in Burundi over the period from January 2007 to July 2022. A single error correction model is used in which the underlying determinants of the food and non-food components of inflation as well as structural factors are incorporated into the headline inflation equation. The major contribution to the existing literature is the study of the role of the tax sector in modeling inflation, an aspect that has been neglected in existing studies on inflation in Burundi.
The empirical results reveal that the long-term sources of headline inflation are determined in the external sector market, where the exchange rate premium, world food and non-food prices determine the domestic prices as well as in the fiscal sector. In the short term, exchange rate movements, energy price adjustments, imported non-food inflation and changes in money growth as well as public sector borrowing influence headline inflation where public sector borrowing plays an important role in inflationary pressures.
Three conclusions can be drawn from these empirical results: First, the dominant influence of the exchange rate on headline inflation and its sub-components deserves special attention from the authorities, who must take consistent measures to curb the depreciation excessive BIF against the US dollar. Second, with regard to the pass-through of imported inflation, expanding and diversifying the manufacturing base to limit the current heavy reliance on imports of manufactured goods and capital goods remains a policy priority. Finally, the role of supply shocks, evident in the impact of food prices on inflation, requires immediate and significant reforms in the agricultural sector to boost productivity through the use of modern production methods.
JEL: E31, 055, C22, E62
Investigation of the influence of an intermediate adapter on the dynamic load of a supporting structure of a platform wagon
Authors: Lovska Alyona , Dizo Jan , Rybin Andrij 
Published: December 2023

Summary: This article is focused on a presentation of the results of the theoretical justification of the use of an intermediate adapter placed between the main supporting structure of a platform wagon and the cargo. Such a decision will contribute to reducing the vertical load of both the supporting structure of a platform wagon and ensuring the safety of the cargo transported on it. The mathematical modelling of the vertical load of a platform wagon supporting structure when moving along the joint unevenness of the track was carried out to substantiate the use of the designed intermediate adapter. In this regard, a corresponding mathematical model was created. There is taken into account an oscillating system consisting of four bodies: the platform wagon supporting structure, two bogies (the 18–100 model) and the cargo. At the same time, the cargo is considered up to the full carrying capacity of the platform wagon. The track is considered elastic-viscous. The mathematical model was solved in the MathCad software. The initial conditions (displacement and velocities) are set to be close to zero. The results of the solution established that the accelerations acting on the platform wagon supporting structure are reduced by 8.4 % compared to those acting on the typical structure without the designed intermediate adapter. The acceleration acting on the cargo placed on the platform wagon frame is 11.9 % lower in comparison with the standard load perception scheme.
The strength analysis of the adapter was calculated considering the determined values of the accelerations. At the same time, the finite element method was used for the strength analysis of the adapter in the SolidWorks Simulation software. It was determined that the calculated maximum stresses in the adapter structure are 4.1 % lower than permissible stress values. Therefore, the strength condition of the adapter is met. The performed research will contribute to a creation of developments in the design of modern designs of railway vehicles
Development of digital twin ecosystem and ontology in medicine
Authors: Mammadova Masuma Huseyn , Ahmadova Aytan Adil 
Published: December 2023

Summary: Providing citizens with high-quality and safe medical services, providing information support for medical research and continuous medical education, making both doctor’s decisions and management decisions necessitated the provision of tools to ensure complex digitization of healthcare. To achieve these goals, a wide range of modern technologies have emerged. One such technology is digital twin technology.
Modern medicine, being formed in the environment of Health 4.0, includes not only the treatment of patients, but also the management of healthcare, the prevention of diseases and the processes of health restoration. With the increasing popularity of information communication technologies, people’s demand for health services is shifting from offline service to new online models. Currently, the field of online medicine is not developed enough to serve the elderly, chronically ill people and the people with infectious diseases. Using the advantages of digital twins in solving these problems can give positive results.
The article describes the nature, capabilities and applications of digital twin technology. The principles of the formation of the medical digital twin ecosystem are developed to ensure citizens’ accessibility to medical services and to make both medical and managerial decisions. The architecture and structural components of the digital twin ecosystem providing the connection between physical medical objects (patient, hospital, doctor, etc.) and their virtual images are shown. An ontological model for the staged construction and functionalization of the general DT of healthcare is proposed and its hierarchical architecture is established
New Functionalized Morpholinothiazole Derivatives: Regioselective Synthesis,
Computational Studies, Anticancer Activity Evaluation, and Molecular Docking Studies
Authors: Assiri Mohammed A. , Ali Tarik E. , Alqahtani Maha N. , Shaaban Ibrahim A. , Shati Ali A. , Alfaifi Mohammad Y. , Elbehairi Serag E.I. 
Published: December 2023

Abstract:
A new series of skeletons 2-(morpholinoimino)-4,5-disubstituted-3-
phenylthiazoles (2-15) was synthesized. The methodology involved the reactions of 1-
morpholino-3-phenyl-thiourea (1) with a variety of α-halocarbonyl compounds under
Hantzsch reaction conditions. The reaction mechanism for some postulated routes was modeled
using quantum mechanical calculations in order to investigate the regioselectivity preference
of this reaction in terms of thermodynamics. The quantum mechanical computations
compiled with experimental IR, 1H- and 13C-NMR spectral analysis supported the favorable
product, which has a thiazole ring bearing the morpholinoimino moiety at position C−2. All
synthesized products were screened using the sulforhodamine B (SRB) assay for their cytotoxic
properties against various cancer cell lines. Fortunately, the target compounds 2, 4, 5,
6, 11, and 12 were discovered to be comparable to doxorubicin in terms of their potency against all evaluated
cell lines. Utilizing flow cytometry, apoptosis and cell cycle analyses were determined and supported by molecular
docking studies. All tumor cells were significantly early- and late-apoptotic affected by the products 2, 4, 5,
6, 11 and 12, and these products also significantly halted all studied types of cancer cells in both S and G2 phases.
The discovered compounds 2 and 12 were then subjected to a molecular docking experiment to examine how
they bind with the VEGFR-2-KDR receptor.
ANTIOXIDANT EFFECT OF MOUTHWASH CONTAINING ZINC, ALOE VERA, AND STABILIZED CHLORINE DIOXIDE FOR ORAL MANIFESTATION OF ACUTE MYELOBLASTIC LEUKEMIA (AML)
Authors: PERMATASANTI AYU , FITRIASAR NURI , SARI NUR MELANI , WAHYUNI INDAH SUASANI 
Published: December 2023

Objective: This paper aims to report a study regarding the successful treatment using zinc, Aloe vera, and stabilized chlorine dioxide as an antioxidant mouthwash in a patient with AML.
Methods: A series of clinical examinations, including subjective and objective examinations, were done to establish the diagnosis.
Results: A 9 y old boy, who was already diagnosed with AML, referred to the oral medicine division because of the hemorrhagic crust of his lips. The extra-oral examination showed severe hemorrhagic crust and erosions on the upper and lower lips. The intra-oral examination could not be evaluated in detail, but the active bleeding was seen. A hematology investigation showed pancytopenia. Patients received packed red cell (PRC) and thrombocyte concentrate (TC) blood transfusions, as well as an antioxidant mouthwash containing zinc, Aloe vera, and stabilized chlorine dioxide, for compressing the lips every 1-2 h with a duration of 30 min. Significant improvement in lip lesions was gained in a short time after blood transfusions and regular use of the mouthwash compresses.
Conclusion: In this study, the mouthwash containing zinc, Aloe vera, and stabilized chlorine dioxide that can accelerate the healing process in our AML patient was estimated due to its antioxidant effects.