bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the distribution of the Hodge locus
Authors: Baldi Gregorio , Klingler Bruno , Ullmo Emmanuel 
Published: November 2023

AbstractGiven a polarizable ℤ-variation of Hodge structures $\mathbb{V}$
V
over a complex smooth quasi-projective base $S$
S
, a classical result of Cattani, Deligne and Kaplan says that its Hodge locus (i.e. the locus where exceptional Hodge tensors appear) is a countable union of irreducible algebraic subvarieties of $S$
S
, called the special subvarieties for $\mathbb{V}$
V
. Our main result in this paper is that, if the level of ${\mathbb{V}}$
V
is at least 3, this Hodge locus is in fact a finite union of such special subvarieties (hence is algebraic), at least if we restrict ourselves to the Hodge locus factorwise of positive period dimension (Theorem 1.5). For instance the Hodge locus of positive period dimension of the universal family of degree $d$
d
smooth hypersurfaces in $\mathbf{P}^{n+1}_{\mathbb{C}}$

P
C

n
+
1

, $n\geq 3$
n
≥
3
, $d\geq 5$
d
≥
5
and $(n,d)\neq (4,5)$
(
n
,
d
)
≠
(
4
,
5
)
, is algebraic. On the other hand we prove that in level 1 or 2, the Hodge locus is analytically dense in $S^{\mbox{an}}$

S
an

as soon as it contains one typical special subvariety. These results follow from a complete elucidation of the distribution in $S$
S
of the special subvarieties in terms of typical/atypical intersections, with the exception of the atypical special subvarieties of zero period dimension.
Associations between visceral adipose index and stress urinary incontinence among US adult women: a cross-sectional study
Authors: Pang Haigang , Yin Yuxin , Xue Juan , Chen Xi , Pang Jian , Zhang Jinping , Sun Yi 
Published: November 2023

Abstract
Objective
Visceral adipose index (VAI) is a novel parameter for the evaluation of visceral obesity. The present study aimed to investigate the association between VAI levels and stress urinary incontinence (SUI) in a nationally representative population.

Materials and methods
The National Health and Nutrition Examination Survey (NHANES) women population aged > 20 years were analyzed from 2001 to 2018. SUI was determined by self-reported questions. VAI was calculated using physical examination data and laboratory tests. Survey-weighted logistic regression models were used to analyze the correlation between SUI and VAI.

Results
The final analysis included 9709 women. Among them, 4032 (41.53%) were any SUI, 1130 (11.64%) were at least weekly SUI, and 506 (5.21%) were at least daily SUI. In multivariate analysis, the odds ratio (OR) for overall SUI increased slightly after full adjustment (OR 1.06, 95% CI 1.03–1.10, P = 0.001). Similar results were observed in weekly (OR 1.04, 95% CI 1.00–1.08, P = 0.0327) and daily (OR 1.04, 95% CI 1.00–1.09, P = 0.0702) SUI. The analysis of VAI categorized showed an increased OR of any, weekly, and daily SUI in the highest compared to the lowest tertile (OR 1.44, 95% CI 1.26–1.65, P < 0.0001 for trend, OR 1.38, 95% CI 1.07–1.78, P = 0.0153 for trend, OR 1.33, 95% CI 0.94–1.87, P = 0.094 for trend).

Conclusion
This study revealed a significant association between SUI and VAI among US adult women. VAI is an easily applicable index for the evaluation of visceral fat dysfunction, which might be useful for the calculation of SUI risk.
Comparative study between antegrade flexible ureteroscopy and reterograde intrarenal surgery in the management of impacted upper ureteric stones 1.5 cm or larger
Authors: Mohey Ahmed , Abdelfattah Ahmed A. , Mohammed Ahmed E. , Marzouk Abdelmoniem , El-Dakhakhny Amr S. 
Published: November 2023

Abstract
Objective
To prospectively investigate the safety and efficacy of antegrade flexible ureteroscopy (FURS) with the following criteria (supine, ultrasonic guided puncture through lower calyx with 14 fr tract, tubeless) versus retrograde intrarenal surgery (RIRS) in the management of large impacted upper ureteric stones ≥ 1.5 cm.

Patients and methods
This study recruited 61 patients with single large impacted upper ureteric stone of ≥ 1.5 cm. The patients were randomly allocated to two groups. Group A, included 31 patients who treated by antegrade FURS, all patients were put in supine modified galadako Valdivia position and the renal access is reached by ultrasonic guided puncture through the lower calyx with dilatation upto 14 fr to insert ureteric access sheath and all cases were tubless with JJ stent insertion. Group B, included 30 patients who were treated by RIRS with JJ stent insertion. Stone fragmentation was done by holmium laser in both group.

Results
Group A was significantly associated with higher proportion of SFR (90.3%) compared to Group B (70%) (p = 0.046). Group B was significantly associated with shorter operative time and fluoroscopy time in comparison with Group A (p < 0.001). No significant differences were found between studied groups regarding bleeding (p = 0.238). Urosepsis showed significantly higher proportion associated with retrograde approach when compared to antegrade approach (p = 0.024).

Conclusion
This study showed that antegrade FURS is safe and more effective than RIRS for the management of large impacted upper ureteric stones ≥ 1.5 cm.
Changes in occurrence and management of laryngeal fractures at the Helsinki University Hospital during 25 years
Authors: Mäkitie Riikka E. , Nyman Kristofer , Ilmarinen Taru , Tapiovaara Laura 
Published: November 2023

Abstract
Purpose
Laryngeal fracture is a rare but potentially life-threatening trauma. Fractures vary from mild to dislocated and extensive with risk of severe complications. This study investigated the occurrence, clinical characteristics and management of laryngeal fractures in the last 15 years.

Material and methods
A retrospective population-based cohort study reviewing all laryngeal fractures at the Helsinki University Hospital in 2005–2019. Patient records and imaging studies were systematically reviewed for mode of injury, fracture type, secondary complications, treatment modality, possible airway management, length of stay, and mortality. Results were compared with corresponding data from 1995 to 2004.

Results
Overall 80 fracture patients were recorded (5.3/year); 79% were men and mean age was 42 years (range 18–78). Altogether 91% were closed and 9% open. While unintentional traumas were most common (54%), an increasing proportion were from intentional injury (10%) or Schaefer Gr IV in severity (35%). Altogether 46% had compromised airway and 21% needed airway intervention; airway narrowing was more common with cricoid (p = 0.042) and multiple fractures (p = 0.07) and correlated positively with amount of dislocation (p = 0.001) and number of fracture lines (p = 0.006). Surgery was performed for 33%, of which 46% were Schaefer Gr IV and 62% from intentional trauma. Mortality was 1.4%.

Conclusions
Deliberate and violence-related laryngeal fractures have increased. These often result in more extensive injuries predisposing to compromised airway and requiring surgical intervention and longer treatment. Most fractures are still treated conservatively with good long-term outcomes. An observation period of 24 h is recommended to detect any delayed complications. Mortality remains low.
Efficacy of topical administration of prallethrin-permethrin-piperonyl butoxide (Bronco® Equine Fly Spray) for the treatment and control of flies and other nuisance insects of horses
Authors: Genchi Marco , Kramer Laura , Valentini Gaia , Allievi Giulia , Ciuca Lavinia , Vismarra Alice 
Published: November 2023

AbstractNumerous biting and nuisance insects are a noted cause of discomfort and stress to horses. Pyrethrins and pyrethroids have been used for many years in numerous formulations for the control of insect pests in animals, humans and environment. There are, however, few studies reporting their field efficacy in horses. The aim of the present study was to evaluate the repellent activity of a spray formulation based on prallethrin and permethrin synergized with piperonyl butoxide (BRONCO® Equine Fly Spray, Farnam Companies, Inc., USA) against annoying and harmful insects for horses in field conditions. Nine horses of mixed breed were divided into 2 groups (treatment and control). Pre-treatment insect counts were compared to daily counts for 4 days post-treatment (pt). One minute after the administration of the product (day 0), all the horses were negative for the presence of insects. All counts up to the 6-h pt check remained negative for Hippobosca equina, tabanid flies and Simulium spp., showing 100% efficacy. This remained above 90% throughout the study. For the H. equina, the repellent efficacy remained > 99.7% for all 4 days pt, for tabanid flies > 93.3% and for Simulium spp. > 97.4%. The efficacy against Musca spp. decreased from 82.2% at day 0 to 62.2% at day 3. Treatment was well-tolerated. In conclusion, despite the low number of tested horses, Bronco® has demonstrated high insecticide and repellent efficacy and a good persistence, maintained for up to 4 days post-treatment, against the most common species of insects harmful for horses.
Quantitative Analysis in Continuous-Flow $$^1$$H Benchtop NMR Spectroscopy by Paramagnetic Relaxation Enhancement
Authors: Kircher Raphael , Mross Sarah , Hasse Hans , Münnemann Kerstin 
Published: November 2023

AbstractNuclear magnetic resonance (NMR) spectroscopy is an excellent tool for reaction and process monitoring. Process monitoring is often carried out online, where the analytic device is operated in flow mode. Benchtop NMR spectrometers are especially well-suited for these applications because they can be installed close to the studied process. However, quantitative analysis of a fast-flowing liquid with NMR spectroscopy is challenging because short residence times in the magnetic field of the spectrometer result in inefficient polarization buildup and thus poor signal intensity. This is particularly problematic for benchtop NMR spectrometers, where it severely limits the flow velocity in quantitative measurements. One method for increasing polarization in continuous-flow NMR spectroscopy is paramagnetic relaxation enhancement (PRE). Here, the interaction of the studied liquid with a PRE agent significantly accelerates the buildup of nuclear polarization prior to NMR detection, which enables quantitative measurements at high flow velocities. For process monitoring applications, the synthesis of robust and chemically inert immobilized PRE agents is mandatory. This was accomplished in the present work, where a new PRE agent is tested on 12 common solvents including water, acetonitrile, 1,4-dioxane, and binary mixtures with quantitative benchtop $$^1$$

1

H NMR spectroscopy at 1 Tesla. The results show that the flow regime for quantitative measurements can be greatly extended by the use of the synthesized PRE agent.
Perturbation Theory for Second Order Elliptic Operators with BMO Antisymmetric Part
Authors: Dindoš Martin , Sätterqvist Erik , Ulmer Martin 
Published: November 2023

AbstractIn the present paper we study perturbation theory for the $$L^p$$

L
p

Dirichlet problem on bounded chord arc domains for elliptic operators in divergence form with potentially unbounded antisymmetric part in BMO. Specifically, given elliptic operators $$L_0 = \text {div}(A_0\nabla )$$

L
0

=
div

(

A
0

∇
)

and $$L_1 = \text {div}(A_1\nabla )$$

L
1

=
div

(

A
1

∇
)

such that the $$L^p$$

L
p

Dirichlet problem for $$L_0$$

L
0

is solvable for some $$p>1$$

p
>
1

; we show that if $$A_0 - A_1$$

A
0

-

A
1

satisfies certain Carleson condition, then the $$L^q$$

L
q

Dirichlet problem for $$L_1$$

L
1

is solvable for some $$q \ge p$$

q
≥
p

. Moreover if the Carleson norm is small then we may take $$q=p$$

q
=
p

. We use the approach first introduced in Fefferman–Kenig–Pipher ’91 on the unit ball, and build on Milakis–Pipher–Toro ’11 where the large norm case was shown for symmetric matrices on bounded chord arc domains. We then apply this to solve the $$L^p$$

L
p

Dirichlet problem on a bounded Lipschitz domain for an operator $$L = \text {div}(A\nabla )$$

L
=
div
(
A
∇
)

, where A satisfies a Carleson condition similar to the one assumed in Kenig–Pipher ’01 and Dindoš–Petermichl–Pipher ’07 but with unbounded antisymmetric part.
Perspectives on Neuromyelitis Optica Spectrum Disorders, the Narrative Medicine contribution to care
Authors: Filippi Massimo , Borriello Giovanna , Patti Francesco , Inglese Matilde , Trojano Maria , Marinelli Fabiana , Chisari Clara , Iaffaldano Pietro , Zanetta Chiara , Chesi Paola , Termini Roberta , Marini Maria Giulia 
Published: November 2023

Abstract
Background
This research aimed to investigate the experience of Neuromyelitis Optica Spectrum Disorders (NMOSD) by integrating the perspectives of patients, caregivers and clinicians through narrative-based medicine to provide new insights to improve care relationships.

Methods
The research was conducted in the second half of 2022 and involved six Italian centres treating NMOSD and targeted adult patients, their caregivers and healthcare providers to collect the three points of view of living with or caring for this rare disease, still difficult to treat despite the pharmacological options. Narratives followed a structured outline according to the time: yesterday-today-tomorrow, to capture all disease phases.

Results
Twenty-five patients diagnosed with NMOSD, ten caregivers and 13 healthcare providers participated in the research. Patients reported symptoms limiting their daily activities and strongly impacting their social dimension. We noticed improvements across disease duration, whilst the persistence of limitations was recurrent in patients with longer diagnoses.
Caregivers’ narratives mainly share experiences of their daily life changes, the burden of the caregiving role and the solutions identified, if any. Healthcare providers defined their role as a guide.

Conclusion
Limitations in activities are prominent in the lives of people with NMOSD, along with fatigue. Family members are the weakest link in the chain and need information and support. Healthcare professionals are attentive to the helping dimension.
Bacteraemia caused by non-faecalis and non-faecium Enterococcus species—a retrospective study of incidence, focus of infection, and prognosis
Authors: Lohikoski Roni , Oldberg Karl , Rasmussen Magnus 
Published: November 2023

Abstract
Background/aim
Enterococcus faecalis and Enterococcus faecium cause human infections including bacteraemia and infective endocarditis (IE). Only few studies describing non-faecalis and non-faecium Enterococcus (NFE) infections have been conducted. We aimed to describe the incidence, prognosis, and focus of infection of bacteraemia with NFE.

Methods
This retrospective population-based study included all episodes of patients having a blood culture with growth of NFE between 2012 and 2019 in Region Skåne, Sweden. Information was collected from medical records. Episodes of bacteraemia caused by NFE were compared to episodes of bacteraemia caused by E. faecalis and E. faecium.

Results
During the study period, 136 episodes with NFE bacteraemia were identified corresponding to an incidence of NFE bacteraemia of 16 cases per 1,000,000 person-years among adults. Enterococcus casseliflavus (n=45), Enterococcus gallinarum (n=34), and Enterococcus avium (n=29) were the most common species. The most common foci of infection were biliary tract infections (n=17) followed by gastrointestinal infections (n=7). Urinary tract infections were not commonly caused by NFE (n=1), and no episodes of IE were caused by NFE. Polymicrobial bacteraemia was more common with NFE (73%) than with E. faecalis (35%) and E. faecium (42%). Community acquired infections were more common in bacteraemia with NFE compared to E. faecium. 30- and 90-day survival rates were 76% and 68%, respectively, and recurrent NFE bacteraemia was seen after 3% of the episodes.

Conclusion
Bacteraemia caused by NFE is rare and is often polymicrobial. Biliary tract focus is common in NFE bacteraemia whereas IE and urinary tract focus are uncommon.
SpaTiaL: monitoring and planning of robotic tasks using spatio-temporal logic specifications
Authors: Pek Christian , Schuppe Georg Friedrich , Esposito Francesco , Tumova Jana , Kragic Danica 
Published: November 2023

AbstractMany tasks require robots to manipulate objects while satisfying a complex interplay of spatial and temporal constraints. For instance, a table setting robot first needs to place a mug and then fill it with coffee, while satisfying spatial relations such as forks need to placed left of plates. We propose the spatio-temporal framework SpaTiaL that unifies the specification, monitoring, and planning of object-oriented robotic tasks in a robot-agnostic fashion. SpaTiaL is able to specify diverse spatial relations between objects and temporal task patterns. Our experiments with recorded data, simulations, and real robots demonstrate how SpaTiaL provides real-time monitoring and facilitates online planning. SpaTiaL is open source and easily expandable to new object relations and robotic applications.
USP10 suppresses ABCG2-induced malignant characteristics of doxorubicin-resistant thyroid cancer by inhibiting PI3K/AKT pathway
Authors: Sun Jianwei , Xiang Qian , Ding Ding , Yan Nan 
Published: November 2023

AbstractDoxorubicin (DOX) is the most extensively used drug in the chemotherapy of thyroid cancer (TC). However, the existence of DOX resistance is not conducive to TC treatment. Here, we investigated the role of USP10 in DOX-resistant TC and explored the underlying molecular mechanism. CCK-8 assay was used to measure cell viability in thyroid cancer FTC133 and DOX-resistant FTC133-DOX cells. RT-qPCR and western blot were used to evaluate USP10 expression. Cell migration, invasion, and apoptotic assays were conducted. Western blot was used to detect cellular signaling proteins, EMT-related proteins, and apoptosis-related proteins. We found a lower expression of USP10 in the human TC cell line FTC133 as compared to the normal human thyroid Htori-3 cells. Notably, USP10 expression was further reduced in DOX-resistant (FTC133-DOX) cells compared to the FTC133 cells. FTC133-DOX cells had increased invasion, migration, and EMT properties while less apoptosis by activating the PI3K/AKT pathway. Interestingly, overexpressing USP10 increased the chemosensitivity of FTC133 cells to DOX therapy. Overexpressing USP10 inhibited invasion, migration, and EMT properties of FTC133-DOX cells and promoted apoptosis. Mechanistically, overexpressing USP10 inhibited PI3K/AKT pathway by activating PTEN. Furthermore, overexpressed USP10 controlled all these processes by downregulating ABCG2. This study demonstrates that USP10 could reduce DOX-induced resistance of TC cells to DOX therapy and could suppress TC malignant behavior by inhibiting the PI3K/AKT pathway. Furthermore, USP10 targeted ABCG2 to inhibit all these malignant processes, therefore, either increasing USP10 expression or inhibiting ABCG2 could be used as novel targets for treating DOX-resistant thyroid cancer.
Kink Waves in Twisted and Expanding Magnetic Tubes
Authors: Ruderman M. S. , Petrukhin N. S. 
Published: November 2023

AbstractWe study kink and fluting waves in expanding and twisted magnetic flux tubes. We use the thin-tube and zero-beta plasma approximations. The equilibrium magnetic field is force free with a constant proportionality coefficient between the electrical current and the magnetic field. We derive the equation governing the kink and fluting waves in a tube. Using this equation we study the propagation of kink waves in a particular case of a magnetic tube homogeneous in the axial direction. We show that while there is only one propagating kink wave with the phase speed equal to the kink speed in an untwisted tube, in a twisted tube there are two wave modes, accelerated and decelerated. The phase speed of the accelerated wave exceeds the kink speed, while the phase speed of the decelerated wave is less than the kink speed. We also show that the standing modes are defined by the same eigenvalue problem as that in the case of an untwisted tube. Hence, the frequencies of the standing-wave modes are not affected by the twist. This implies that the seismological results based on the observation of the standing-wave mode frequencies remain valid when the twist is taken into account. The only effect of twist is the variation of the direction of polarisation of the coronal magnetic-loop displacement along the loop. As a result, an apparent node can be detected near the loop apex if only one component of the loop displacement is observed. This can lead to an incorrect conclusion that the observed coronal loop kink oscillation was the first overtone, while in fact it was the fundamental mode.
ZnO nanostructured matrix as nexus catalysts for the removal of emerging pollutants
Authors: Matei Ecaterina , Șăulean Anca Andreea , Râpă Maria , Constandache Alexandra , Predescu Andra Mihaela , Coman George , Berbecaru Andrei Constantin , Predescu Cristian 
Published: November 2023

AbstractWater pollution stands as a pressing global environmental concern, elevating the significance of innovative, dependable, and sustainable solutions. This study represents an extensive review of the use of photocatalytic zinc oxide nanoparticles (ZnO NPs) for the removal of emerging pollutants from water and wastewater. The study examines ZnO NPs’ different preparation methods, including physical, chemical, and green synthesis, and emphasizes on advantages, disadvantages, preparation factors, and investigation methods for the structural and morphological properties. ZnO NPs demonstrate remarkable properties as photocatalysts; however, their small dimensions pose an issue, leading to potential post-use environmental losses. A strategy to overcome this challenge is scaling up ZnO NP matrices for enhanced stability and efficiency. The paper introduces novel ZnO NP composites, by incorporating supports like carbon and clay that serve as photocatalysts in the removal of emerging pollutants from water and wastewater. In essence, this research underscores the urgency of finding innovative, efficient, and eco-friendly solutions for the removal of emerging pollutants from wastewater and highlights the high removal efficiencies obtained when using ZnO NPs obtained from green synthesis as a photocatalyst. Future research should be developed on the cost–benefit analysis regarding the preparation methods, treatment processes, and value-added product regeneration efficiency.
Graphical Abstract
Learning curve for robotic rectal cancer resection at a community-based teaching institution
Authors: Coleman Kristen , Fellner Angela N. , Guend Hamza 
Published: November 2023

AbstractThe surgical management of rectal cancer is shifting toward more widespread use of robotics across a spectrum of medical centers. There is evidence that the oncologic outcomes are equivalent to laparoscopic resections, and the post-operative outcomes may be improved. This study aims to evaluate the learning curve of robotic rectal cancer resections at a community-based teaching institution and evaluate clinical and oncologic outcomes. A retrospective review of consecutive robotic rectal cancer resections by a single surgeon was performed for a five-year period. The cumulative sum (CUSUM) for total operative time was calculated and plotted to establish a learning curve. The oncologic and post-operative outcomes for each phase were analyzed and compared. The CUSUM learning curve yielded two phases, the learning phase (cases 1–79) and the proficiency phase (cases 80–130). The median operative time was significantly lower in the proficiency phase. The type of neoadjuvant therapy used between the two groups was statistically different, with chemoradiation being the primary regimen in the learning phase and total neoadjuvant therapy being more common in the proficiency phase. Otherwise, oncologic and overall post-operative outcomes were not significantly different between the groups. Robotic rectal resections can be done in a community-based hospital system by trained surgeons with outcomes that are favorable and similar to larger institutions.