bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does acute isolated sphenoidal sinusitis meet the criteria of the recent acute sinusitis guidelines, EPOS2020?
Authors: Farhat Raed , Khater Ashraf , Khatib Nidal El , Asakly Majd , Ron Aviva , Safia Alaa , Karam Marwan , Massoud Saqr , Avraham Yaniv , Merchavy Shlomo 
Published: January 2024

Abstract
Introduction
Isolated sphenoidal sinusitis (ISS) is a rare disease with non-specific symptoms and a potential for complications. Diagnosis is made clinically, endoscopically, and with imaging like CT scans or MRIs. This study aimed to evaluate if ISS meets the EPOS 2020 criteria for diagnosing acute rhinosinusitis and if new diagnostic criteria are needed.

Materials and methods
The study analyzed 193 charts and examination records from 2000 to 2022 in patients diagnosed with isolated sphenoidal sinusitis at the Ziv Medical Center in Safed, Israel. Of the 193, 57 patients were excluded, and the remaining 136 patients were included in the final analysis. Patients were evaluated using Ear, Nose and Throat (ENT), neurological and sinonasal video endoscopy, radiological findings, demographic data, symptoms and signs, and laboratory results. All these findings were reviewed according to the EPOS 2020 acute sinusitis diagnosis criteria and were analyzed to determine if ISS symptoms and signs fulfilled them.

Results
The patients included 40 men and 96 women, ranging in age from 17 to 86 years (mean ± SD, 37 ± 15.2 years). A positive endoscopy and radiography were encountered in 29.4%, and headache was present in 98%; the most common type was retro-orbital headache (31%). The results showed that there is no relationship between the symptoms of isolated sphenoidal sinusitis and the criteria for diagnosing acute sinusitis according to EPOS 2020.

Conclusion
ISS is an uncommon entity encountered in clinical practice with non-specific symptoms and a potential for complications. Therefore, the condition must be kept in mind by clinicians, and prompt diagnosis and treatment must be initiated. This kind of sinusitis does not fulfill the standard guidelines for acute sinusitis diagnosis criteria.
Vemurafenib combined with chemotherapy achieved sustained remission in pediatric LCH: a multi-center observational study
Authors: Lei Jiaying , Wang Wenxia , Lin Danna , Zhu Chengguang , Jia Wenguang , Weng Wenjun , Liu Xiaoshan , Ma Yuhan , Wang Zhixuan , Yang Lihua , He Xiangling , He Yunyan , LI Yang 
Published: January 2024

Abstract
Background
Langerhans cell histiocytosis (LCH) is a myeloid neoplasia with potentially fatal consequences, and about 2/3 of cases involve the BRAFV600E kinase-activated mutation. Vemurafenib, a BRAF inhibitor, has demonstrated significant clinical improvements in LCH. However, the high relapse rate of LCH following cessation of vemurafenib therapy remains a major challenge, and alternative treatment strategies require further investigation.

Methods
In this retrospective multi-center study, we evaluated the efficacy and safety of vemurafenib combined with conventional chemotherapy in patients with severe or refractory LCH.

Results
Seventeen patients were enrolled in the study, with eleven classified as risk organ involvement (RO +). Six received the combination therapy as the primary treatment, and eleven after being refractory to prior chemotherapy. The overall response rate was 94.1%. Progression-free survival among all 17 patients was 70.6% (12/17) at a median follow-up of 32 months, and relapse-free survival among the 15 patients with discontinuation after a response was 73.3%(11/15) at a median follow-up of 34 months. Five of six patients (83.3%) with myeloid BRAFV600E mutations demonstrated molecular remission. The overall survival rate was 100%. Adverse events were mostly classified as grades 1 or 2.

Conclusion
Our data suggest that the combination of vemurafenib and chemotherapy can achieve sustained clinical and molecular level relief in children with LCH, and side effects are tolerable.
Exploring the effects of missense mutations on protein thermodynamics through structure-based approaches: findings from the CAGI6 challenges
Authors: Rodrigues Carlos H. M. , Portelli Stephanie , Ascher David B. 
Published: January 2024

AbstractMissense mutations are known contributors to diverse genetic disorders, due to their subtle, single amino acid changes imparted on the resultant protein. Because of this, understanding the impact of these mutations on protein stability and function is crucial for unravelling disease mechanisms and developing targeted therapies. The Critical Assessment of Genome Interpretation (CAGI) provides a valuable platform for benchmarking state-of-the-art computational methods in predicting the impact of disease-related mutations on protein thermodynamics. Here we report the performance of our comprehensive platform of structure-based computational approaches to evaluate mutations impacting protein structure and function on 3 challenges from CAGI6: Calmodulin, MAPK1 and MAPK3. Our stability predictors have achieved correlations of up to 0.74 and AUCs of 1 when predicting changes in ΔΔG for MAPK1 and MAPK3, respectively, and AUC of up to 0.75 in the Calmodulin challenge. Overall, our study highlights the importance of structure-based approaches in understanding the effects of missense mutations on protein thermodynamics. The results obtained from the CAGI6 challenges contribute to the ongoing efforts to enhance our understanding of disease mechanisms and facilitate the development of personalised medicine approaches.
Knowledge mapping of surgical smoke from 2003 to 2022: a bibliometric analysis
Authors: Li Chuang , Geng Meng , Li Shujun , Li Xianglan , Li Huiqin , Yuan Hufang , Liu Fengxia 
Published: January 2024

Abstract
Purpose
The purpose of this study is to identify and characterize the literature on surgical smoke, visualize the data and sketch a certain trending outline.

Methods
In the Web of Science Core Collection (WoSCC), all the data were acquired from January 1st 2003 to December 31st 2022. VOSviewer and CiteSpace were employed to visualize data, based on publications, bibliographic coupling, co-citation, or co-authorship relations. Microsoft Excel 2019 was used to comb and categorize all the statistics.

Result
A total 363 of journal papers were retrieved. The publication number was in a slow but steady growth between 2003 and 2019, followed by a sharp surge in 2020, and then the publication kept in a productive way. Surgical endoscopy and other interventional techniques was the most active journal on surgical smoke. USA played an important role among all the countries/regions. There were 1847 authors for these 363 papers, among whom 44 authors published more than three articles on surgical smoke. “Surgical smoke”, “covid-19” and “surgery” were the top 3 appeared keywords, while the latest hot-spot keywords were “COVID-19”, “virus”, “transmission”, “exposure” and “risk”. There were 1105 co-cited references and 3786 links appeared in all 363 articles. Among them, 38 references are cited more than 10 times. The most co-cited article was “Detecting hepatitis B virus in surgical smoke emitted during laparoscopic surgery.” Based on the titles of references and calculated by CiteSpace, the top 3 cluster trend network are “laparoscopic surgery”, “COVID-19 pandemic” and “surgical smoke”.

Conclusion
According to bibliometric analysis, the research on surgical smoke has been drawing attention of more scholars in the world. Increasing number of countries or regions added in this field, and among them, USA, Italy, and China has been playing important roles, however, more wide and intense cooperation is still in expectation.
The Past, Present, and Future of the Cognitive Theory of Multimedia Learning
Authors: Mayer Richard E. 
Published: January 2024

AbstractThe cognitive theory of multimedia learning (Mayer, 2021, 2022), which seeks to explain how people learn academic material from words and graphics, has developed over the past four decades. Although the name and graphical representation of the theory have evolved over the years, the core ideas have been constant—dual channels (i.e., humans have separate information processing channels for verbal and visual information), limited capacity (i.e., processing capacity is severely limited), and active processing (i.e., meaningful learning involves selecting relevant material to be processed in working memory, mentally organizing the material into coherent verbal and visual structures, and integrating them with each other and with relevant knowledge activated from long-term memory). This review describes how the theory has developed (i.e., the past), the current state of the theory (i.e., the present), and new directions for future development (i.e., the future). In addition, the review includes examples of the events and findings that led to changes in the theory. Implications for educational psychology are discussed, including 15 evidence-based principles of multimedia design.
Investment law v. supply-side climate policies: insights from Rockhopper v. Italy and Lone Pine v. Canada
Authors: Arcuri Alessandra , Tienhaara Kyla , Pellegrini Lorenzo 
Published: January 2024

AbstractNew fossil fuel developments are inconsistent with keeping global warming below 1.5 °C, and while most climate policies focus on reducing demand for fossil fuels, an emerging transversal consensus promotes efforts to simultaneously reduce supply. In this article, we discuss the obstacles to effective supply-side climate policies posed by international investment treaties that protect corporations against state interventions through investor-state dispute settlement (ISDS). We focus on two recently concluded ISDS cases (Rockhopper v Italy and Lone Pine v Canada) that concern prohibitions on fossil fuel development in ecologically sensitive areas. Italy was ordered to pay a British firm approximately € 250 million in compensation for a ban on offshore oil developments along the coastline, whereas Canada successfully defended Québec’s ban on gas development in the St. Lawrence River. Arbitrators in both cases reasoned that investors should be compensated when oil and gas exploration permits are revoked (even if such a remedy is not available under domestic law) and expressed antipathy towards civic engagement in the policy process. As companies can seek lost future profits through ISDS, these cases show that the system can engender material costs for states enacting supply-side policies. The threat of ISDS can generate a chilling effect, limiting the potential for supply-side initiatives, particularly in the Global South. Initiators of global efforts to limit further fossil fuel developments must consider the obstacles posed by international investment treaties, support efforts to abolish ISDS, and as an interim measure, promote the interpretation of treaty protections in line with climate objectives.
Multi-agent cooperative swarm learning for dynamic layout optimisation of reconfigurable robotic assembly cells based on digital twin
Authors: Wang Likun , Wang Zi , Gumma Kevin , Turner Alison , Ratchev Svetan 
Published: January 2024

AbstractTo meet the requirement of product variety and short production cycle, reconfigurable manufacturing system is considered as an effective solution in addressing current challenges, such as increasing customisation, high flexibility and dynamic market demand. Dynamic factory layout design and optimisation are the crucial factors in response to rapid change in the mechanical structure, software and hardware integration, as well as production capability and functionality adjustment. Nevertheless, in the current research, the layout design for reconfigurable manufacturing systems is usually simplified with autonomous devices being regarded as 2D shapes. Issues such as overlapping and transportation distance are also addressed in an approximate form. In this paper, we present a novel multi-agent cooperative swarm learning framework for dynamic layout optimisation of reconfigurable robotic assembly cells. Based on its digital twin established in the proposed learning environment (constructed in Visual Components and controlled by TWINCAT), the optimisation framework uses 3D digital representation of the facility models with minimal approximation. Moreover, instead of using a traditional centralised learning manner, multi-agent system could provide an alternative way to address the layout issues combined with the proposed decentralised multi-agent cooperative swarm learning. In order to verify the application feasibility of the learning framework, two aerospace manufacturing use cases were implemented. In the first use case, the layout compactness is reduced by 3.8 times compared with the initial layout setting, the simulated production time is reduced by 2.3 times, and the rearrangement cost decreased by 33.4$$\%$$%. In addition, all manufacturing activity within the cell can be achieved with a feasible robot path, meaning without any joint limits, reachability or singularity issue at each key assembly point. In the second use case, we demonstrated that with the proposed dynamic layout optimisation framework, it is possible to flexibly adjust learning objectives by selecting various weight parameters among layout compactness, rearrangement cost and production time.
CPG-Fuzzy Heading Control for a Hexapod Robot with Arc-Shaped Blade Legs
Authors: Zhang Yani , Cui Rongxin , Li Haoquan , Guo Xinxin 
Published: January 2024

AbstractBased on the central pattern generator (CPG) and fuzzy controller, this paper proposes a heading control method for the directional motion for a new type of blade legged hexapod robot (BLHR). First, the modified Hopf oscillator is used to construct the CPG model of BLHR based on the limit cycle. Second, the fuzzy controller is applied to adjust the support angles of legs to change the heading of BLHR, thereby correcting the error between the actual and desired heading angle in real-time. Finally, the feasibility and effectiveness of the proposed CPG-Fuzzy control method is verified in Gazebo simulations and real-world experiments. This is the first attempt to combine CPG and fuzzy control in the context of hexapod robot. In comparison to existing control methods, the proposed CPG-Fuzzy controller can implement heading control of BLHR with better performance and value of further investigation.
Single and binary nickel, copper, and zinc-based nanosized oxides as anode materials in lithium-ion batteries
Authors: Egesoy Evren , Kap Özlem , Bardak Fehmi , Horzum Nesrin , Ataç Ahmet 
Published: January 2024

AbstractThe demand for portable power sources with higher energy density and longer lifespan has prompted researchers to focus on developing better electrode materials for lithium-ion batteries (LIBs). Metal oxide nanoparticles have potential due to their low cost, high surface-area-to-volume ratio, strong reactivity, excellent size distribution, high theoretical capacities, and eco-friendly synthesis methods. However, there is still room for improvement in capacity retention and rate performance. To cope with this entail, the cycle performance of LIBs has been initially investigated utilizing single metal oxide anode materials including NiO, CuO, and ZnO nanostructures. Subsequently, binary oxides of Ni–Cu, Ni–Zn, and Cu–Zn have been synthesized to examine whether the binary structures boost the battery performance. NiCuO is the optimum anode material combining the benefits of NiO with the highest initial discharge capacity of 691 mAh g$$^{-1}$$

-
1

and the highest retention rate of CuO (49% after 30 cycles).
Dependence of drag coefficient on the spectral width of ocean waves
Authors: Zhao Dongliang , Li Moxin 
Published: January 2024

AbstractThe sea-surface roughness or drag coefficient is ascribed to the effect of various components of ocean waves. Many studies have been focused on the investigation of the dependence of drag coefficient on sea states that are usually denoted by wave age. However, no universally accepted relationship has been obtained up to now and the results are significantly scattered or even contradicted. We reviewed the parameterizations of sea-surface roughness as a function of wave age, and found that the phase speed at spectral peak cp is an important parameter to characterize the drag coefficient. For the same wave age, drag coefficient increases with increasing cp. Contrary to the traditional concept, the older waves with greater cp possesses higher sea-surface roughness for the same wind speed because more wave components participate the air–sea interaction and intensify the wind stress. With the buoy meansurements and the theory of equilibrium range of wind waves, we estimated fricition velocity and proposed that the frequency bandwidth and spectral width of the wave spectrum are more suitable parameters than the traditional wind speed and wave age to be used to parameterize drag coefficient. This study provides a new way to estimate wind stress through the reliable spectra of ocean waves.
Polyhedral Approximation of Spectrahedral Shadows via Homogenization
Authors: Dörfler Daniel , Löhne Andreas 
Published: January 2024

AbstractThis article is concerned with the problem of approximating a not necessarily bounded spectrahedral shadow, a certain convex set, by polyhedra. By identifying the set with its homogenization, the problem is reduced to the approximation of a closed convex cone. We introduce the notion of homogeneous $$\delta $$
δ
-approximation of a convex set and show that it defines a meaningful concept in the sense that approximations converge to the original set if the approximation error $$\delta $$
δ
diminishes. Moreover, we show that a homogeneous $$\delta $$
δ
-approximation of the polar of a convex set is immediately available from an approximation of the set itself under mild conditions. Finally, we present an algorithm for the computation of homogeneous $$\delta $$
δ
-approximations of spectrahedral shadows and demonstrate it on examples.
Ca/Sn concentration-dependent enhancement of barium titanate ferroelectric performance: a dielectric and microstructural study
Authors: Rashwan G. M. , Ebnalwaled A. A. , Saad E. M. , Shahat M. Abdelhamid 
Published: January 2024

AbstractThis work involved the synthesis of compositions of Ba0.95Ca0.05SnxTi1-xO3 (BCST) with varying amounts of Sn dopant (x = 0, 0.02, 0.04, 0.06, 0.08, and 0.1). A standard solid-state reaction approach was used to create all of the ceramic compounds. Each BCST composite’s microstructure, sintering, morphology, density, optical, and electrical characteristics were carefully examined, and the dielectric performance was optimized. In comparison to the unmodified composite, introducing varied amounts of Sn material into the BCST compound changed the crystal lattice vibrations and functional group locations. This result indicates that there are some variations in unit cell size, revealing that Sn+4 ions diffused effectively inside the lattice structure to produce BSCT composites. Further, SEM micrographs indicated proportionate changes in the homogenous structure and irregular forms as Sn concentration increased, as well as some variation in average grain size. As a consequence, by adding 0.08 mol% of Sn dopant, the crystallite size and average grain size were adjusted to 45.69 nm and 0.66 µm, respectively. Meanwhile, the 0.08-Sn specimen displayed a dielectric constant (Ɛ) with an optimum value of 5557 and a relative decrease in the Curie-Weiss constant. These results are attributed to the existence of various concentrations of Sn ions at the Ti-site of the BCT, which resulted in a compositionally disordered state. This disordered condition is essential for the production of dielectric compounds. Therefore, it is evident that modifying the amount of Sn doping added significantly enhanced the dielectric characteristics of the BCST composites created in this work. However, excessive Sn doping reduces the dielectric properties due to a reduction in tetragonal phase and an increase of disorders and charge fluctuations.
Graphical Abstract
A robust blind color watermarking algorithm based on the Radon-DCT transform
Authors: Bao Bin , Wang Yu 
Published: January 2024

AbstractDigital watermarking is an effective technique for image copyright protection. Many digital image watermarking algorithms are sensitive to geometric distortions. These distortions make it difficult to detect and extract watermarks. In this study, a robust color watermarking algorithm combining the Radon transform and DCT transform is proposed. First, the color carrier image is converted to the YUV color space from RGB, and the U component of YUV is transformed to the Radon domain using the Radon transform. Then, a two-dimensional 8 × 8 discrete cosine transform (2D-DCT) is carried out on the selected blocks of the Radon domain, and some fixed midfrequency coefficients are selected to embed watermark information. Moreover, the Arnold transform is applied to encrypt the watermarks and the random permutation function to scramble the embedding positions. Finally, the watermark embedding and blind extraction processes are completed by modifying the midfrequency coefficients using the presented rules. A series of simulation experiments show that the watermark algorithm has high imperceptibility and good robustness to various attacks.
Enabling secure health information sharing among healthcare organizations by public blockchain
Authors: Lax Gianluca , Nardone Roberto , Russo Antonia 
Published: January 2024

AbstractThe facilitation of sharing and exchanging patients’ health records is a paramount opportunity in e-health, enabling healthcare providers to garner a comprehensive and clear perspective of patients’ medical histories without necessitating direct inquiries. Besides this great advantage, it introduces substantial issues on security and privacy, mainly related to unauthorized access to e-health records when different healthcare service providers maintain records. In this paper, we deal with this problem and propose using the blockchain technology (1) to obfuscate the linkage between patients’ identities and their e-health records and (2) to grant access to e-health records exclusively to entities authorized by patients themselves. Key outcomes include using a digital identity based on the Electronic Identification, Authentication, and Trust Services Regulation (eIDAS) to control access to these records, and a concrete implementation by adopting the Ethereum blockchain. Our solution relies on using a public blockchain, which is an improvement for the state of the art, in which only private or consortium blockchains have been proposed. The resulting solution has been analyzed, and the effectiveness and affordability of the proposal have been shown.
Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176
Authors: Konings Mickey , Gerrits van den Ende Bert , Raats Mirthe W. J. , Fahal Ahmed Hassan , van de Sande Wendy W. J. , Hagen Ferry 
Published: January 2024

AbstractMadurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.