bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies
Authors: Koushik Anita , Hunter David J. , Spiegelman Donna , Anderson Kristin E. , Arslan Alan A. , Beeson W. Lawrence , van den Brandt Piet A. , Buring Julie E. , Cerhan James R. , Colditz Graham A. , Fraser Gary E. , Freudenheim Jo L. , Genkinger Jeanine M. , Goldbohm R. Alexandra , Hankinson Susan E. , Koenig Karen L. , Larsson Susanna C. , Leitzmann Michael , McCullough Marjorie L. , Miller Anthony B. , Patel Alpa , Rohan Thomas E. , Schatzkin Arthur , Smit Ellen , Willett Walter C. , Wolk Alicja , Zhang Shumin M. , Smith-Warner Stephanie A. 
Published: September 2005

AbstractBecause fruits and vegetables are rich in bioactive compounds with potential cancer-preventive actions, increased consumption may reduce the risk of ovarian cancer. Evidence on the association between fruit and vegetable intake and ovarian cancer risk has not been consistent. We analyzed and pooled the primary data from 12 prospective studies in North America and Europe. Fruit and vegetable intake was measured at baseline in each study using a validated food-frequency questionnaire. To summarize the association between fruit and vegetable intake and ovarian cancer, study-specific relative risks (RR) were estimated using the Cox proportional hazards model, and then combined using a random-effects model. Among 560,441 women, 2,130 cases of invasive epithelial ovarian cancer occurred during a maximum follow-up of 7 to 22 years across studies. Total fruit intake was not associated with ovarian cancer risk—the pooled multivariate RR for the highest versus the lowest quartile of intake was 1.06 [95% confidence interval (95% CI), 0.92-1.21; P value, test for trend = 0.73; P value, test for between-studies heterogeneity = 0.74]. Similarly, results for total vegetable intake indicated no significant association (pooled multivariate RR, 0.90; 95% CI, 0.78-1.04, for the highest versus the lowest quartile; P value, test for trend = 0.06; P value, test for between-studies heterogeneity = 0.31). Intakes of botanically defined fruit and vegetable groups and individual fruits and vegetables were also not associated with ovarian cancer risk. Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer.
Relative and Absolute Risks of Cigarette Smoking on Major Histologic Types of Lung Cancer in Korean Men
Authors: Yun Young Ho , Lim Min Kyung , Jung Kyu Won , Bae Jong-Myon , Park Sang Min , Shin Soon Ae , Lee Jin Soo , Park Jae-Gahb 
Published: September 2005

Abstract
Objectives: Most prospective cohort studies of lung cancer focus on the relative risk rather than the absolute risk of smoking.
Methods: This prospective study included 437,976 Korean men (cohort for the National Health Insurance Cooperation Study), ≥40 years old, who were free of cancer and smoking-related chronic disease at the time of enrollment. Based on new incidence cases, relative risk and excess risk, and their 95% confidence intervals (95% CI), were estimated with the standard Poisson regression model after adjustment for age or other demographic factors and other confounders.
Results: During the 6-year follow-up period of 3,142,451 person-years, 1,357 new lung cancer cases were identified. Based on the multivariate-adjusted relative risk for current smokers, the strongest association with smoking was shown for small-cell lung cancer (relative risk, 21.7; 95% CI, 8.0-58.5) followed by squamous cell carcinoma (relative risk, 11.7; 95% CI, 7.1-19.4) and then adenocarcinoma (relative risk, 2.1; 95% CI, 1.6-2.7). In current smokers with ≥40 pack-years of exposure, excess risk was highest for squamous cell carcinoma (excess risk, 33.8; 95% CI, 10.2-109.8) followed by adenocarcinoma (excess risk, 26.7; 95% CI, 10.3-64.4), and then small-cell carcinoma (excess risk, 16.3; 95% CI, 1.8-144.3).
Conclusions: In Korean men, cigarette smoking was as important a risk factor for adenocarcinoma as it was for squamous cell and small-cell lung cancer.
Multivitamin and Alcohol Intake and Folate Receptor α Expression in Ovarian Cancer
Authors: Kelemen Linda E. , Sellers Thomas A. , Keeney Gary L. , Lingle Wilma L. 
Published: September 2005

AbstractFolate receptor α (FRα) expression in epithelial ovarian cancer may be related to folate intake. We examined this association using multivitamin intake, a proxy for folic acid, and assessed whether the relation was modified by alcohol intake, a folate agonist. Cases (n = 148) with suspected epithelial ovarian cancer, of ages ≥20 years, were seen at Mayo Clinic, Minnesota, between 2000 and 2004; those with tumor specimens (n = 108) were included in analyses. Outpatient controls (n = 148) without cancer and with at least one ovary intact were matched to cases by age (within 5 years) and state of residence. Multivitamin (≥4 pills/wk) and weekly alcohol (≥5 drinks) intakes were assessed. Tumor specimens were analyzed immunohistochemically for FRα. Multivariable rate ratios (RR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression. In case-control analysis, the RRs of multivitamin intake with absent/weak/moderate and strong-expressing FRα tumors were 0.30 (95% CI, 0.12-0.70) and 0.47 (95% CI, 0.24-0.91), respectively. For alcohol, the associations were 0.84 (95% CI, 0.24-2.86) and 1.65 (95% CI, 0.69-3.93), respectively. In case-case analysis, the RR associated with developing strong-expressing versus other FRα tumors was 3.13 (95% CI, 1.14-8.65) for multivitamins and 1.58 (95% CI, 0.45-5.60) for alcohol. The data did not support evidence for an interaction between multivitamin and alcohol intake with risk of developing a strong-expressing FRα tumor. The association of multivitamin intake with ovarian cancer may depend on FRα expression level.
Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome
Authors: Offman Judith , Gascoigne Karen , Bristow Fiona , Macpherson Peter , Bignami Margherita , Casorelli Ida , Leone Giuseppe , Pagano Livio , Sica Simona , Halil Ozay , Cummins David , Banner Nicholas R. , Karran Peter 
Published: September 2005

Abstract
Microsatellite instability (MSI) in tumors is diagnostic for inactive DNA mismatch repair. It is widespread among some tumor types, such as colorectal or endometrial carcinoma, but is rarely found in leukemia. Therapy-related acute myeloid leukemia/myelodysplastic syndrome (tAML/MDS) is an exception, and MSI is frequent in tAML/MDS following cancer chemotherapy or organ transplantation. The development of MSI+ tumors is associated with an accumulation of insertion/deletion mutations in repetitive sequences. These events can cause inactivating frameshifts or loss of expression of key growth control proteins. We examined established MSI+ cell lines and tAML/MDS cases for frameshift-like mutations of repetitive sequences in several genes that have known, or suspected, relevance to leukemia. CASPASE-5, an acknowledged frameshift target in MSI+ gastrointestinal tract tumors, was frequently mutated in MSI+ cell lines (67%) and in tAML/MDS (29%). Frameshift-like mutations were also observed in the NF1 and FANCD2 genes that are associated with genetic conditions conferring a predisposition to leukemia. Both genes were frequent targets for mutation in MSI+ cell lines and colorectal carcinomas. FANCD2 mutations were also common in MSI+ tAML/MDS, although NF1 mutations were not observed. A novel FANCD2 polymorphism was also identified.
The influence of the steepness of dominance hierarchies on reciprocity and interchange in captive groups of bonobos (Pan paniscus)
Authors: de Vries Han , Stevens Jeroen M.G. , Van Elsacker Linda , Vervaecke Hilde 
Published: September 2005

AbstractBiological market models explain variability in reciprocity and interchange between groups. In groups with a shallow dominance gradient, grooming will be mostly exchanged for itself (i.e. exchange will occur). In groups with steep dominance hierarchies, interchange is expected: individuals will groom higher ranking individuals to get access to limited resources or commodities such as support in conflicts, and grooming will be traded for these commodities.We examine patterns of reciprocity in grooming and support, and of interchange of grooming for support or for tolerance in six captive groups of bonobos. We test whether differences between groups in patterns of reciprocity and interchange can be attributed to differences in a measure of steepness of dominance hierarchies, which is based on dyadic agonistic interactions.We found that grooming was reciprocal in some, but not all groups. Support was highly reciprocal, but this was a side effect of dominance in most groups. Interchange between grooming and support was observed in some groups. Corroborating earlier findings, this was a side effect of individuals preferring high ranking individuals as grooming and support partners, possibly because these high-ranking individuals provide more efficient support in conflicts. There was no evidence for interchange of grooming for tolerance.Variability in grooming reciprocity was explained by differences in steepness of dominance hierarchies, as predicted by the biological market models. In groups with a shallow dominance hierarchy, grooming was more reciprocal. This was not true for reciprocity in support. There was some evidence that individuals groomed dominants more frequently in groups with a steep dominance hierarchy. The variation in interchange relations between grooming and support did not depend on the steepness of dominance hierarchies. We suggest that grooming in itself is a valuable commodity in bonobos, especially under captive conditions, which can be exchanged reciprocally. Bonobos may interchange grooming for another value equivalent, with food sharing as a very likely candidate. This interchange effects seem more dependent on potential to monopolise food than on steepness of dominance hierarchies per se.
The social suppression of caching in western scrub-jays (Aphelocoma californica)
Authors: Emery Nathan J. , Dally Joanna M. , Clayton Nicola S. 
Published: September 2005

AbstractThis study focussed on the social suppression of caching in 3 groups of western scrub-jays (Aphelocoma californica). Each group (3 males and 4 females) were housed in a separate aviary. Only the dominant male and/or his partner cached in each aviary. When the alpha pair was removed from the aviary, however, caching by the beta pair increased significantly. As all subordinate birds cache when housed individually, cache cessation was attributed to social suppression. In each aviary, storers from both the alpha and beta pairs tolerated their partners recovering their caches, but treated all other birds aggressively if they approached a cache site. The storer and their partner tended to move one another's caches around multiple times, possibly making the final location of caches ambiguous. Importantly, caches were only moved around repeatedly on trials where multiple pilfering attempts were made. Western scrub-jays therefore appear to adjust their caching behaviour depending on the risk that observers pose to their caches.
Wandering in male fiddler crabs (Uca tangeri): alternative reproductive tactic or a functional constraint?
Authors: Jordão J.M. , Oliveira R.F. 
Published: September 2005

AbstractThe 'aggressive wandering' behaviour of male fiddler crabs is well documented in several species and is usually described as an apparently random movement through a population, punctuated by threats and combat directed at displaying males, and superficial burrow explorations. It has been suggested that wandering males are mainly low condition individuals with a regenerating major claw, unsuccessful at attracting mates, wandering through the population seeking surface copulations as an alternative to burrow copulations, which may be considered an alternative reproductive tactic. In order to test this hypothesis we have made several predictions. We observed several focal wandering males, compared sizes of wandering and resource holder individuals, and monitored their abundance across the lunar cycle. We did not observe any surface copulation attempts in any of our focal subjects. The number of burrows explored by wandering males was highly variable and not dependent on the subject's size although larger males do spend more time superficially exploring burrows. Wandering males are significantly larger than burrow-holder males and there was a peak in wandering in the first moon quarter. We conclude that it is important to dissociate wandering from surface copulations and that wandering is not an alternative reproductive tactic for lower condition males. The number of wandering males across the lunar cycle still suggests that wandering may be related to mating and we discuss several ways in which it could be possible.
Sexual segregation in bison: a test of multiple hypotheses
Authors: Schaad Eric W. , Wiseman David S. , Huber Royce R. , Mooring Michael S. , Reisig Dominic D. , Osborne Eric R. , Kanallakan Adam L. , Hall Brent M. 
Published: September 2005

AbstractSexual segregation, in which males and females form separate groups for most of the year, is common in sexually dimorphic ungulates. We tested multiple hypotheses to explain sexual segregation in bison (Bison bison) at National Bison Range, Montana and Fort Niobrara National Wildlife Refuge, Nebraska during June-August of 2002-2003. Fieldwork involved use of GPS to record space use by segregated groups, vegetation transects to measure forage availability, fecal analyses to document diet composition and quality, and behavioural observations to characterize activity budgets. During sexual segregation, males in bull groups used areas with greater per capita abundance of forage, higher proportion of weeds, and less nutritious grasses (as indicated by lower % fecal nitrogen) compared with females in cow or mixed groups. However, there was no difference between the sexes in activity budgets, predation risk factors, or distance to water. Single-sex bull groups were no more synchronized in activity than mixed groups. These results support the 'sexual dimorphism-body size hypothesis', which proposes that males segregate from females because their larger body size requires more abundant forage, while longer ruminal retention permits efficient use of lower-quality forage. The gastrocentric model, based on the digestive physiology and foraging requirements of dimorphic ungulates, supplies the most likely proximate mechanism for bison sexual segregation. Our results would also partly support the 'reproductive strategy-predation risk hypothesis' if females form large groups to reduce predation risk. The predictions of the 'activity budget hypothesis' were not supported for bison.
The optimal foraging strategy of its stickleback host constrains a parasite's complex life cycle
Authors: Milinski Manfred , Christen Mira 
Published: September 2005

AbstractThe cestode parasite Schistocephalus solidus' growth is limited by the size of its second intermediate host, the three-spined stickleback, Gasterosteus aculeatus. S. solidus should thus prefer a large stickleback as host. Since the stickleback is a predator of the parasite's previous intermediate host, a small copepod, the stickleback that consumes the infected copepod will probably be of a size for which this copepod has the optimal prey size. The optimal foraging decision of the stickleback may or may not be compatible with the parasite's preference. Infected copepods are present in early summer when both many size classes of young of the year and adult sticklebacks are potential predators. We offered laboratory bred three-spined sticklebacks of four size classes individually the choice among five prey types: two size classes of copepods, two classes of Daphnia of corresponding size as alternative prey and a third Daphnia size class that was larger than the larger copepod. We found that small copepods, the potential hosts of S. solidus, were most accepted by the smallest sticklebacks of about 1.5 cm of length, larger fish consumed a decreasing proportion; fish larger than 3.8 cm did not consume them at all. Experience with copepods over several weeks increased the acceptance for this prey to some extend but hardly in the largest fish. This suggests that S. solidus will end up usually in sticklebacks that are too small for the parasite so that it has to allow its host's further growth after infection to reach its definitive size.
Socialization of infant blue monkeys (Cercopithecus mitis stuhlmanni): Allomaternal interactions and sex differences
Authors: Förster Steffen , Cords Marina 
Published: September 2005

AbstractAn important part of the ontogeny of social mammals is the establishment of social relationships with non-mothers. Mothers may influence this socialization process, but other factors like the number and kind of potential partners available may also be important. In matrilineal societies, variation in allomaternal social experience is also likely to differ for males and females, relating to differences in their respective life histories. We investigated differences in non-maternal social relationships of 12 infant blue monkeys (Cercopithecus mitis stuhlmanni) in their first six months of life in a wild population. Based on previous findings that blue monkey infants develop spatial independence from their mothers at a relatively early age, we expected that infants would also socialize with non-maternal group members early in life. As possible determinants of variation in infant socialization, we evaluated the effects of age, sex, group composition, and timing of birth relative to the birth season. Allomaternal social relationships of infants differed between social groups, largely but not exclusively in response to differences in group composition. Adjusting for these group differences, we found that infants generally avoided spatial proximity to non-maternal adult females, whereas they associated more than expected by chance with other infants and large juvenile females, when away from their mothers. Close spatial association with other adult females and small juveniles increased when infants were near their mothers. Association with other infants decreased with proximity to the mother, apparently because peer playgroups led infants away from their mothers. Infants were spatially well integrated into the core of the group, associating with most available adult and large juvenile partners. Male infants spent more time in social play than females, and engaged in more rough-and-tumble play bouts, and in bouts of longer duration, than females. Large juvenile females regularly took care of infants, whereas adult females rarely acted as caretakers. There were no sex differences in behavior directed towards infants by non-mothers, but female infants associated more than male infants with adult females when away from their mothers. Although sex differences in social play correspond to similar differences in the importance of fighting skills for adults, alternative explanations for the observed pattern remain plausible. Our data support the hypothesis that allomaternal care functions as infant handling practice for nulliparous females. The relatively rapid social development we observed in our subjects contrasts with the generally slow life history of the species and suggests that developmental rates during infancy and juvenility are promoted and constrained by different factors.
The Role of Social Anthropology in the Debate on Funeral Rites in Africa
Authors: van 't Spijker Gerard 
Published: September 2005

AbstractIn view of the actual debate on funeral rites in Christian Churches in Africa, a revision of the old position of missionaries that forbade all traditional ritual concerning death as belonging to paganism should be undertaken on the basis of social anthropological research which analyses structure and function of the funeral practices. Thus the mourning rites are understood as means of purification and reconciliation of the bereaved extended family. Parallels between African rituals and those of Israel of the Old Testament may also be taken into account. The efforts towards contextualisation of the Christian message in days of mourning by the ancient Ethiopian Church and by churches in Zimbabwe of today may serve as guidelines for developing rituals marking the end of mourning focused on reconciliation and the victory of life over death.
The Message of Jesus and our Customary Theological Language: An Indian Approach to a New Language in Theology and Inculturation
Authors: Mattam  
Published: September 2005

AbstractThe Asian Context demands a new language in theology, as both the Bible and the past theological formulations are conditioned by their time, place and problems. The Paschal Mystery needs to be understood in the light of the picture of God given by Jesus as an unconditionally loving Parent. Jesus was killed because of the way he lived and spoke of God. Hence we need to look afresh at the sacrificial interpretation of Jesus' death. The title Christ is conditioned by the expectations of the Jewish people, and Jesus, the Son of God we honour, is more and other than what they expected. Past theological developments did not come from this picture of God, and from Jesus' outlook, his options and priorities; they were responses to the problems of their times, conditioned more by Platonic and Aristotelian philosophy, than by the good news that Jesus proclaimed. In the context of the 'Old Testament' of the peoples of these places, with Jesus' option for the poor, we need to announce the simple message of Jesus to let new theologies and liturgies emerge. Certain conditions are necessary for any true inculturation of the gospel message.
Chromosomal clustering of a human transcriptome reveals regulatory background
Authors: Vogel Jan H , von Heydebreck Anja , Purmann Antje , Sperling Silke 
Published: September 2005

Abstract
Background
There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and gene function in higher eukaryotes remains to be precisely defined.

Results
Here, we present evidence for organization of a large proportion of a human transcriptome into gene clusters throughout the genome, which are partly regulated by the same transcription factors, share biological functions and are characterized by non-housekeeping genes. This analysis was based on the cardiac transcriptome identified by our genome-wide array analysis of 55 human heart samples. We found 37% of these genes to be arranged mainly in adjacent pairs or triplets. A significant number of pairs of adjacent genes are putatively regulated by common transcription factors (p = 0.02). Furthermore, these gene pairs share a significant number of GO functional classification terms. We show that the human cardiac transcriptome is organized into many small clusters across the whole genome, rather than being concentrated in a few larger clusters.

Conclusion
Our findings suggest that genes expressed in concert are organized in a linear arrangement for coordinated regulation. Determining the relationship between gene arrangement, regulation and nuclear organization as well as gene function will have broad biological implications.