bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14
Authors: Matveichuk Orest V. , Ciesielska Anna , Hromada-Judycka Aneta , Nowak Natalia , Ben Amor Ichrak , Kwiatkowska Katarzyna 
Published: December 2023

AbstractLipopolysaccharide induces a strong pro-inflammatory reaction of macrophages upon activation of Toll-like 4 receptor (TLR4) with the assistance of CD14 protein. Considering a key role of plasma membrane rafts in CD14 and TLR4 activity and the significant impact exerted on that activity by endocytosis and intracellular trafficking of the both LPS acceptors, it seemed likely that the pro-inflammatory reaction could be modulated by flotillins. Flotillin-1 and -2 are scaffolding proteins associated with plasma membrane rafts and also with endo-membranes, affecting both the plasma membrane dynamics and intracellular protein trafficking. To verify the above hypothesis, a set of shRNA was used to down-regulate flotillin-2 in Raw264 cells, which were found to also become deficient in flotillin-1. The flotillin deficiency inhibited strongly the TRIF-dependent endosomal signaling of LPS-activated TLR4, and to a lower extent also the MyD88-dependent one, without affecting the cellular level of TLR4. In contrast, the depletion of flotillins down-regulated the CD14 mRNA level and the total cellular content of CD14 protein, and decreased the amount of CD14 on the cell surface. The constitutive CD14 endocytosis remained unchanged but CD14 recycling was enhanced via EEA1-positive early endosomes and golgin-97-positivetrans-Golgi network, likely to compensate for the depletion of the cell-surface CD14. Notably, a paucity of surface CD14 in resting cells can inhibit TLR4 signaling after the stimulation of cells with LPS. In conclusion, we have shown here that flotillins modulate the pro-inflammatory response of macrophages to LPS by affecting the abundance of CD14.
The logic behind evolution of economic systems under uncertainty and the choice of a socialist market economy
Authors: Qiao Zhen 
Published: December 2023

PurposeThis paper aims to determine the status of the socialist market economy through a logical analysis of the evolution of economic systems in human society.Design/methodology/approachThis paper presents an analysis of uncertainty and the functions performed by different economic systems in managing and resolving it, thereby explaining the evolutionary rationale behind economic system evolution.FindingsFirstly, the socialist market economy empowers the market to play a decisive role in resource allocation, which serves as the foundation for activating individuals' motivation to engage in economic activities. Secondly, the socialist market economy adheres to the basic socialist economic system, which is the basis for the socialist market economy to stabilize the economy and society or to address the risk of economic uncertainty that may trigger macro-level inconsistencies in economic operations. Thirdly, the advantages of a socialist market economy in adapting to economic uncertainties do not arise spontaneously and must be exerted through continuous improvement of the socialist market economy.Originality/valueThe innovation of this paper lies in introducing uncertainty to clarify the logic behind the evolution of economic systems in human society and explaining the typical significance of the socialist market economy and its advantages in accommodating and resolving uncertainty.
Satya Pharmaceuticals’ foray into global markets
Authors: Paluri Ratna Achuta , Mishra Girish Ranjan 
Published: December 2023

Learning outcomes
This case study will allow students to critically analyse and develop entry strategies into untapped foreign markets. The case study was designed to introduce students to identifying and analysing information related to target markets for expansions in international business.
The main objectives of this case are to evaluate and make the “Go Global” decision for the company; to take a position on entry timing for a company for entering an overseas market; to select a country for entry based on cultural, administrative, geographic and economic analysis and other relevant factors; and to evaluate a firm’s readiness for exports.

Case overview/synopsis
This case study on Satya Pharmaceuticals presents a typical dilemma faced by small and medium enterprises (SMEs) in emerging markets such as India while exploring the untapped overseas markets to expand their business. Satya Pharmaceuticals produced over-the-counter Ayurvedic medicines. With the onset of the COVID-19 pandemic, the consumer preference for Ayurvedic products had increased globally. Home country governments’ emphasis on exports and conducive consumer preferences created an opportune time for such SMEs to explore uncharted markets with a propensity for herbal medicines. Amidst strict regulations regarding safety, efficacy, labelling and packaging norms, along with a subjective understanding of the consumers’ sentiments regarding alternate medicines, SMEs had to select their target market carefully for their products to be successful overseas. This case study presents the basic information that entrepreneurs needed to explore the foreign markets. It revolved around checking firms’ preparedness to explore foreign markets, identifying target markets, timing the entry and entering those markets.

Complexity academic level
This case is appropriate for graduate-level courses in management that offer subjects such as international business.

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS 5: International business.
Sustainability reporting and impact assessment at higher education institute in India
Authors: Chaudhary Sanjay , Trivedi Shantanu 
Published: December 2023

Learning outcomes
An instructor engaged students in managing and reporting sustainability initiatives at an organisation. After completion of the case study discussion, the students will be able to critique the sustainability initiatives that can be undertaken at an organisation; understand sustainability reporting; analyse how result-based management aids in sustainability report preparation; recommend critical considerations for conducting a sustainability impact assessment by an educational institute.
The case contributed to the growing knowledge base about reporting sustainability initiatives at an organisation and managing them to aid in decision-making. The case called for better integration between sustainability activities and reporting under organisations’ Sustainable Development Goals (SDGs) or environmental, social and governance (ESG) reporting.

Case overview/synopsis
Ajay served as the head of the management department and a leading member of the sustainability initiatives at University Alpha, Delhi NCR, India. He was assigned the task of publishing the university’s annual report. The management had requested him to consider preparing a standalone sustainability report for the university.
He began the task by examining the benefits of standalone sustainability reporting. He proceeded to analyse the specifics of SDG reporting, SDG Accord reporting and ESG reporting using the Global Reporting Initiative guidelines. During discussions with a consultant, the necessary steps for creating an SDG-only report and an integrated SDG and ESG sustainability report were clarified.
Guidance from an expert led to an intention to use a result matrix in preparing the sustainability report and ongoing impact assessment of SDG initiatives for reporting. The dilemma involved deciding between continuing with the sustainability initiative listing in the annual reports or opting for a standalone sustainability report. Critical considerations concerning the sustainability impact assessment of SDG-related activities at an educational organisation were also explored.

Complexity academic level
This case is intended for discussion in the graduate-level program in strategy, general management, sustainability management, environmental management and environmental economics. The case may also be used for participants in executive program.

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS 4: Environmental Management.
The impact of professional mentoring on mentors of novice-teachers
Authors: Schatz Oppenheimer Orna , Goldenberg Judy 
Published: December 2023

PurposeThis article aims to present a unique dimension to mentor studies in that unlike most research that focuses on the novice-teachers-mentee, this study explores the influence of mentoring on the mentors themselves. Two main questions were examined: “Which components of mentoring influence the mentors' professional development?” and “What is the differential impact of each of these components as they are internalized by the mentors?”Design/methodology/approachA total of 765 mentors completed a questionnaire composed of 47 multiple-choice questions and an open-ended question describing the contribution of mentoring. The survey thus generated both quantitative and qualitative data.FindingsThe results show three main components of mentoring that influence mentors' professional development in the following order: personal–emotional, didactic knowledge and systemic–organizational. The findings also illustrate how the mentors used a comparison process to develop their professional perception: first, by comparing their role as a teacher and their role as a mentor, and second, by comparing their own professional identity as a teacher with that of the novice-teacher.Research limitations/implicationsThe implications of the study point to the importance of mentoring for mentors' professional development. Practical implications of this study encourage mentor training courses that combine a body of knowledge of theory and practice, as well as supervision and mentoring for mentors. It may be important for mentors to develop a professional identity as mentors that is distinct from their professional identity as teachers.Practical implicationsThe implications of the study point to the importance of mentoring for mentors' professional development. Practical implications of this study encourage mentor training courses that combine a body of knowledge of theory and practice, as well as supervision and mentoring for mentors. It may be important for mentors to develop a professional identity as mentors that is distinct from their professional identity as teachers.Originality/valueThe manuscript attempts to explore the dynamic relationships within the mentoring process by investigating how mentoring impacts the development of mentors. It presents insights into the benefits of mentoring novice-teachers for the mentors themselves via analysis of a large-scale, nationwide study.
The contribution of Enactus global sustainability initiative to youth empowerment and community development
Authors: Omotosho Ademola Olumuyiwa 
Published: December 2023

Purpose
This study aims to explore the contribution of Enactus sustainability initiatives to youth empowerment and community development, thus analysing how South African higher education institutions can increase student involvement in Enactus projects across all faculties.

Design/methodology/approach
Using a systematic literature review approach, the authors searched the Web of Science database for 47 relevant studies, which were found and filtered using the search parameters, and then 33 articles that are strictly relevant to the main topic were chosen as the final corpus.

Findings
The authors found that Enactus facilitates community progress through transformative innovations and students gain valuable skills that increase their employability regardless of their field of study.

Research limitations/implications
The focus of this study is confined to scholarly evidence acquired from peer-reviewed journals, hence empirical studies could be conducted by using literature from books, theses, bulletins, government white papers and gazettes.

Practical implications
These findings highlight several merits of Enactus skill-based training such as learning-by-doing, learning from failures and learning from entrepreneurs.

Social implications
The study findings offer compelling evidence that student transformational innovations could facilitate sustainable development within communities.

Originality/value
Despite the crucial contribution of Enactus projects to nation-building worldwide, literature on this phenomenon in the context of South Africa is limited.
How do departmental professional learning communities and teacher leadership matter for teacher self-efficacy? A multi-level analysis
Authors: Zheng Xin , Luo Ying 
Published: December 2023

PurposeWhilst professional learning communities (PLCs) have been widely explored at the school level, they have received less attention at the departmental level. The study takes the variance between departments and the role of departmental teacher leaders into consideration, and the relationships amongst departmental-level PLC dimensions, two types of teacher leadership (TL) and individual teacher self-efficacy are investigated.Design/methodology/approachThe sample consisted of 907 teachers from 81 departments in Chinese schools. The associations between the studied variables were explored through a multi-level analysis approach.FindingsThe results show that two specific characteristics of departmental PLCs, namely reflective dialogue (RD) and collective responsibility (CR), exhibit a positive correlation with individual teacher self-efficacy. Additionally, the findings indicate that teacher transformational leadership significantly predicts teacher self-efficacy, whereas teacher instructional leadership (IL) does not emerge as a significant predictor. These findings may be attributed to the contextual factors of Chinese teachers' collective work and the practice of teacher leaders.Originality/valueThis research contributes to the existing literature by addressing the variance between departments and uncovering the impacts of departmental PLC dimensions on individual teachers. Furthermore, two TL styles at the departmental level are differentiated, and their distinct influences on teacher self-efficacy are further analysed.
Tinkering with symptoms, causes and solutions: Tracing the enactments of multiple chronic illnesses in specialised outpatient check‐ups
Authors: Skovgaard Anna Louise , Jørgensen Marianne Johansson , Tjørnhøj‐Thomsen Tine , Høybye Mette Terp 
Published: December 2023

AbstractPeople living with multiple chronic illnesses and an increasing need for acute care is a global health challenge, which questions the conventional ways of managing illness. A central issue is how medical practices can become more patient‐centred and aligned with the everyday life of patients. Communicative strategies for eliciting the patient's goals and preferences are often proposed. In this article, we draw on ethnographic data from fieldwork conducted during 2019–2020 in health‐care settings and among people living with multiple chronic illness(es) and repeated acute admissions in Denmark. Inspired by science and technology studies of chronic illness and care, we trace the enactments of illness and illness work in a patient trajectory marked by persistent symptoms and medical complexity. We analyse three medical encounters, and we show how ‘tinkering’ with clinical signs and utterances in each encounter constantly enacts new versions, shaping how the patient could and should live with his illness. We argue that specialised outpatient check‐ups for these patients must provide space for continuous tinkering with the concrete effects of illness in everyday life.
Predicting risk of endometrial cancer in asymptomatic women (PRECISION): Model development and external validation
Authors: Kitson Sarah J. , Crosbie Emma J. , Evans D. Gareth , Lophatananon Aritaya , Muir Kenneth R. , Ashcroft Darren , Kontopantelis Evan , Martin Glen P. 
Published: December 2023

AbstractObjectivesDevelop an endometrial cancer risk prediction model and externally validate it for UK primary care use.DesignCohort study.SettingThe UK Biobank was used for model development and a linked primary (Clinical Practice Research Datalink, CPRD) and secondary care (HES), mortality (ONS) and cancer register (NRCAS) dataset was used for external validation.PopulationWomen aged 45–60 years with no history of endometrial cancer or hysterectomy.MethodsModel development was performed using a flexible parametric survival model and stepwise backward selection aiming to minimise the Akaike information criterion. Model performance on external validation was assessed through flexible calibration plots, calculation of the expected to observed ratio and C‐statistic and decision curve analysis.Main outcome measuresEndometrial cancer diagnosis within 1–10 years of the index date.ResultsModel development included 222 031 women (902 incident endometrial cancer cases) and external validation 3 094 371 women (8585 endometrial cancer cases). The final model (with equation provided) incorporated age, body mass index, waist circumference, age at menarche, menopause and last birth, hormone replacement, tamoxifen and oral contraceptive pill use, type 2 diabetes, smoking and family history of bowel cancer. It was well calibrated on external validation (calibration slope 1.14, 95% confidence interval [CI] 1.11–1.17, E/O 1.03, 95% CI 1.01–1.05), with moderate/good discrimination (C‐statistic 0.70, 95% CI 0.69–0.70) and had improved net benefit compared with previously developed models.ConclusionsThe Predicting risk of endometrial cancer in asymptomatic women model (PRECISION), using easily measurable anthropometric, reproductive, personal and family history, accurately quantifies a woman's 10‐year risk of endometrial cancer. Its use could determine eligibility for primary endometrial cancer prevention trials and for targeted resource allocation in UK general practices.
Economic policy uncertainty and green growth in IEA member countries: A role of environmental stringency policy
Authors: Rasheed Muhammad Qamar , Ahad Muhammad , Shahzad Khurram , Imran Zulfiqar Ali 
Published: December 2023

AbstractAs environmental challenges continue to escalate, policymakers around the globe are prioritizing green growth (GG). This is complicated by the impact of two crucial factors, namely economic policy uncertainty (EPU) and environmental policy stringency (EPI), on the estimates for GG. Therefore, this study investigates the impact of these variables on GG while controlling trade and human development in International Energy Agency member countries from 1990 to 2020. After establishing the existence of a long‐run relationship through the Westerlund cointegration test, the Panel Mean Group autoregressive distributed lag, FMOLS, and DOLS are employed. The findings show that EPU has an inverse impact while EPI positively impacts GG in the long run. Additionally, in Brazil, China, Denmark, and Sweden, the error correction model indicates that EPU has a negative relationship, while EPI has a positive relationship with GG in the short run. Furthermore, a feedback causality was detected between GG, EPU, EPI, and Human Development Index. However, unidirectional causality has been captured running from trade to GG. This research also presents some new insights for policymakers.
Determinants of material footprint in OECD countries: The role of green innovation and environmental taxes
Authors: Karlilar Selin , Pata Ugur Korkut 
Published: December 2023

AbstractThe economic progress of OECD countries is highly dependent on the use of materials. However, excessive material use may cause OECD countries to deviate from their Sustainable Development Goals (SDGs), particularly SDGs 8 and 12. Therefore, it is an important policy agenda to analyze the determinants of the material footprint (MF) and seek solutions to reduce it. This study examines the impact of green innovation, environmental policy strategy, and environmental taxes on MF for 30 OECD countries from 2000 to 2019 using the cross‐sectional ARDL (CS‐ARDL) approach within the framework of the environmental Kuznets Curve (EKC). The outcomes indicate that the EKC hypothesis is valid for MF. Moreover, the long‐term results indicate that green innovation, environmental policy stringency, and environmental taxes are important policy tools to reduce MF. Therefore, OECD countries should promote green innovation, upsurge environmental taxes, and implement stringent environmental policies to the achievement of SDGs 8 and 12.
How positive and negative intergroup contact jointly inform minority support for social change: The role of system‐fairness beliefs
Authors: Árnadóttir Katrín , Baysu Gülseli , Van Laar Colette , Phalet Karen , Tropp Linda R. , Sebben Simone , Ullrich Johannes , Hässler Tabea 
Published: December 2023

AbstractResearch suggests that positive contact with majorities may ‘sedate’ (undermine) minority support for social change, while negative contact may promote it. However, most studies to date have examined both forms of contact separately, which may not give an accurate picture of their effects. This study examines the joint effects and interplay of positive and negative contact on minority support for social change, and the role of system‐fairness beliefs across seven ethnic minority samples in six countries (N = 790). Multigroup Structural Equation Modelling showed that negative contact predicted higher minority support for social change. Positive contact predicted both less support for social change indirectly via enhanced system‐fairness beliefs, and more support for social change directly. Except for one national context, the total effects of positive contact were either non‐significant or significantly positive. This shows that increased system‐fairness beliefs can explain sedative effects of positive contact, and that positive contact may also promote support for social change. We conclude that sedative effects of positive contact may be overestimated by not considering negative contact.
A change of heart: Characteristics and outcomes of multiple cardiac retransplant recipients
Authors: Batra Jaya , DeFilippis Ersilia M. , Clerkin Kevin , Bae David , Oh Kyung Taek , Lotan Dor , Topkara Veli K. , Lee Sun Hi , Latif Farhana , Colombo Paolo , Yuzefpolskaya Melana , Raikhelkar Jayant , Majure David T. , Sayer Gabriel , Uriel Nir 
Published: December 2023

AbstractBackgroundAmong heart transplant (HT) recipients who develop advanced graft dysfunction, cardiac re‐transplantation may be considered. A smaller subset of patients will experience failure of their second allograft and undergo repeat re‐transplantation. Outcomes among these individuals are not well‐described.MethodsAdult and pediatric patients in the United Network for Organ Sharing (UNOS) registry who received HT between January 1, 1990 and December 31, 2020 were included.ResultsBetween 1990 and 2020, 90 individuals received a third HT and three underwent a fourth HT. Recipients were younger than those undergoing primary HT (mean age 32 years). Third HT was associated with significantly higher unadjusted rates of 1‐year mortality (18% for third HT vs. 13% for second HT vs. 9% for primary HT, p < .001) and 10‐year mortality (59% for third HT vs. 42% for second HT vs. 37% for primary HT, p < .001). Mortality was highest amongst recipients aged >60 years and those re‐transplanted for acute graft failure. Long‐term rates of CAV, rejection, chronic dialysis, and hospitalization for infection were also higher.ConclusionsThird HT is associated with higher morbidity and mortality than primary HT. Further consensus is needed regarding appropriate organ stewardship for this unique subgroup.