bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial activity of solid surfaces is critically dependent on relative humidity, inoculum volume, and organic soiling
Authors: Kaur Harleen , Rosenberg Merilin , Kook Mati , Danilian Dmytro , Kisand Vambola , Ivask Angela 
Published: December 2023

Abstract
Antimicrobial surface materials potentially prevent pathogen transfer from contaminated surfaces. Efficacy of such surfaces is assessed by standard methods using wet exposure conditions known to overestimate antimicrobial activity compared to dry exposure. Some dry test formats have been proposed but semi-dry exposure scenarios e.g. oral spray or water droplets exposed to ambient environment, are less studied. We aimed to determine the impact of environmental test conditions on antibacterial activity against the model species Escherichia coli and Staphylococcus aureus. Surfaces based on copper, silver, and quaternary ammonium with known or claimed antimicrobial properties were tested in conditions mimicking microdroplet spray or larger water droplets exposed to variable relative air humidity in the presence or absence of organic soiling. All the environmental parameters critically affected antibacterial activity of the tested surfaces from no effect in high-organic dry conditions to higher effect in low-organic humid conditions but not reaching the effect size demonstrated in the ISO 22169 wet format. Copper was the most efficient antibacterial surface followed by silver and quaternary ammonium based coating. Antimicrobial testing of surfaces using small droplet contamination in application-relevant conditions could therefore be considered as one of the worst-case exposure scenarios relevant to dry use surfaces.
The “Mother of All Protests” Meets Israeli Older Persons: When Age and Gender Intersect in Political Protests
Authors: Ayalon Liat , Okun Sarit 
Published: December 2023

Abstract

Objectives
The Israeli government’s announcement of a judicial overhaul has resulted in ongoing protests and strikes starting in early 2023. The present study examines the intersection between age and gender in political protests.

Methods
The present qualitative study is based on interviews with 13 men and 17 women over the age of 65 who participated in the protests. We conducted qualitative thematic analysis comparing and contrasting categories within and between interviews, while taking the gender perspective into account.

Results
The study highlights patterns of gendered but also older-age protesting practices. Whereas men fought for the sake of past generations, women protested mainly for the sake of their children and grandchildren. In addition, men tended to capitalize on their past achievements as fighters, whereas women emphasized their current achievements as grandmothers.

Discussion
Our findings suggest that under some circumstances, even stereotypical devalued attributes (e.g., being a grandmother) can be used as powerful tools to attract supporters and fight for a cause. Older men, on the other hand, tend to hold on to their past achievements as fighters, at the top of the hegemonic hierarchy to ensure their power and status in current protests. To ensure the appeal of political protests, heterogeneity in motives and protesting styles should be acknowledged.
Partisan YouTube use and evaluation of knowledge in Korea and the United States: a fresh perspective via the Dunning–Kruger effect
Authors: Lee Hoon , Kim Hyeonwoo , Yeon Jiyoung 
Published: December 2023

Abstract
This study investigates how partisan YouTube use can paint biased evaluations of one’s own as well as others’ knowledge. Understanding of these relationships is enriched by a fresh theoretical perspective via the Dunning–Kruger effect, suggesting that people, especially those who perform poorly, tend to overestimate their own competence. Using South Korea and the United States as two different contexts, we also attend to how cultures moderate these relationships. Findings based on two independent surveys in these countries shed light on the role of partisan YouTube use in shaping people’s hyperbolic self-evaluations and contrasted assessments of in- and out-group members. Furthermore, these trends are more pronounced among those with relatively a low level of actual knowledge. Finally, using partisan YouTube for news is strongly associated with group-based evaluations of knowledge in Korea, whereas it yields significant relationships only with self-evaluations of knowledge in the United States.
Impact of Sickle Cell Awareness Day on online health information seeking in Africa using Google Trends
Authors: Parry Emma , Ayinla-Jimoh Idayat , Shepherd Thomas A 
Published: December 2023

Abstract
The United Nations Council Assembly recognized sickle cell disease (SCD) as a global public health problem due to its increasing burden, particularly in sub-Saharan Africa. To raise awareness, a resolution was adopted, designating June 19th as SCD awareness day. However, the impact of this awareness day on online health information seeking behaviour (OHISB) in African countries is not well understood, especially in Nigeria, Ghana and Uganda where SCD prevalence is high. To assess the impact, the study used Google Trends data as a measure of OHISB for SCD. The analysis covered the 60 days before the awareness day, the awareness day itself, and the 60 days afterward. Time series analysis was conducted using joinpoint regression to identify significant changes in OHISB trends. The results indicated that the impact of the Sickle Cell Awareness Day on OHISB varied across African countries and did not consistently inspire significant changes in information seeking behaviour. This suggests the need for more targeted awareness campaigns to improve public knowledge of SCD in Africa. It also highlights the importance of revising the current awareness day or creating alternative health awareness initiatives that adopt a long-term approach and address the specific health needs of the African population. Furthermore, due to limitations in using Google Trends data in some African countries with insufficient data, future research should explore other sources of internet data or conduct surveys to gain a more comprehensive understanding of the impact of the Sickle Cell Awareness Day on OHISB in Africa.
Media coverage of commercial industry activities impacting Aboriginal and Torres Strait Islander health, 2018–2022
Authors: Crocetti Alessandro Connor , Cubillo (Larrakia) Beau , Hill (Torres Strait Islander) Karen , Carter (Yorta Yorta) Morgan , Paradies (Wakaya) Yin , Backholer Kathryn , Browne Jennifer 
Published: December 2023

Abstract
This study aimed to examine the extent and nature of Australian news media coverage of commercial industry activities that explicitly speak to Aboriginal and Torres Strait Islander contexts. We undertook content and framing analysis of Australian newspaper and online media articles published between January 2018 and March 2022 that included terms related to ‘Indigenous’, ‘commercial’ and ‘health’. Analysis focused on the nature of coverage, framing of responsibility, patterns over time and stakeholder representation. Forty-six media articles were included in the analysis. Half of these articles related to the actions of three companies (Woolworths, WAM Clothing and Rio Tinto). Most articles described negative health and well-being impacts of commercial activity, while four described positive impacts. The most common voice represented in media articles was from industry (n = 25). Aboriginal or Torres Strait Islander voices were represented in 21 articles. This analysis highlights how commercial activities in Australia are reported to negatively influence Aboriginal and Torres Strait Islander health and well-being, and that industry voices are more commonly represented in the media related to these issues.
The impact of maternal pertussis vaccination recommendation on infant pertussis incidence and mortality in the USA: an interrupted time series analysis
Authors: Psaras Catherine , Regan Annette , Nianogo Roch , Arah Onyebuchi A , Seamans Marissa J 
Published: December 2023

Abstract

Background
Pertussis is a contagious respiratory disease. Maternal tetanus–diphtheria–acellular pertussis vaccination during pregnancy has been recommended by the United States Centres for Disease Control (US CDC) Advisory Committee on Immunization Practices (ACIP) for unvaccinated pregnant women since October 2011 to prevent infection among infants; in 2012, ACIP extended this recommendation to every pregnancy, regardless of previous vaccination status. The population-level effect of these recommendations on infant pertussis is unknown. This study aimed to examine the impact of the 2011/2012 ACIP pertussis recommendation on pertussis incidence and mortality among US infants.

Methods
We used monthly data on pertussis deaths among infants aged &lt;1 year between January 2005 and December 2017 in the CDC Death Data and yearly infant pertussis incidence data from the CDC National Notifiable Disease Surveillance System to perform an interrupted time series analysis, accounting for the passage of the Affordable Care Act.

Results
This study included 156 months of data. A potential decline in trend in infant pertussis incidence was noted during the post-recommendations period. No appreciable differences in trend were found in population-level infant pertussis mortality after the guideline changes in both adjusted and unadjusted models. Results were similar for all mortality sensitivity analyses.

Conclusions
The 2011/2012 ACIP maternal pertussis vaccination recommendations were not associated with a population-level change in the trend in mortality, but were potentially associated with a decrease in incidence in the USA between 2005 and 2017.
Existence of unattainable states for Schrödinger type flows on the half-line
Authors: Özsarı Türker , Kalimeris Konstantinos 
Published: December 2023

Abstract
We prove that the solutions of the Schrödinger and biharmonic Schrödinger equations do not have the exact boundary controllability property on the half-line by showing that the associated adjoint models lack observability. We consider the framework of $L^2$ boundary controls with data spaces $H^{-1}(\mathbb{R}_+)$ and $H^{-2}(\mathbb{R}_+)$ for the classical and biharmonic Schrödinger equations, respectively. The lack of controllability on the half-line contrasts with the corresponding dynamics on a finite interval for a similar regularity setting. Our proof is based on an argument that uses the sharp fractional time trace estimates for solutions of the adjoint models. We also make several remarks on the connection of controllability and temporal regularity of spatial traces.
Analysis of In-Patient Evolution of Escherichia coli Reveals Potential Links to Relapse of Bone and Joint Infections
Authors: Thiriet-Rupert Stanislas , Josse Jérôme , Perez-Pascual David , Tasse Jason , Andre Camille , Abad Lélia , Lebeaux David , Ghigo Jean-Marc , Laurent Frédéric , Beloin Christophe 
Published: December 2023

Abstract
Bone and joint infections (BJIs) are difficult to treat and affect a growing number of patients, in which relapses are observed in 10–20% of case. These relapses, which call for prolonged antibiotic treatment and increase resistance emergence risk, may originate from ill-understood adaptation of the pathogen to the host. Here, we investigated 3 pairs of Escherichia coli strains from BJI cases and their relapses to unravel adaptations within patients. Whole-genome comparison presented evidence for positive selection and phenotypic characterization showed that biofilm formation remained unchanged, contrary to what is usually described in such cases. Although virulence was not modified, we identified the loss of 2 virulence factors contributing to immune system evasion in one of the studied strains. Other strategies, including global growth optimization and colicin production, likely allowed the strains to outcompete competitors. This work highlights the variety of strategies allowing in-patient adaptation in BJIs.
ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development
Authors: Kanno Toshio , Miyako Keisuke , Endo Takeru , Yokoyama Satoru , Asou Hikari K , Yamada Kazuko , Ohara Osamu , Nakayama Toshinori , Kimura Motoko Y , Endo Yusuke 
Published: December 2023

Abstract
To meet the energetic requirements associated with activation, proliferation, and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controlling the development of invariant natural killer T (iNKT) cells. In the present study, we found that acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme for the fatty acid biosynthesis pathway, plays an essential role in the development of iNKT cells in the thymus. Mice lacking T-cell specific ACC1 showed a reduced number of iNKT cells with an increased proportion of iNKT cells at immature stages 0 and 1. Furthermore, mixed bone marrow (BM) chimera experiments revealed that T-cell intrinsic ACC1 expression was selectively important for the development of thymic iNKT cells, especially for the differentiation of the NKT1 cell subset. Our single-cell RNA-sequencing (scRNA-seq) data and functional analysis demonstrated that ACC1 is responsible for survival of developing iNKT cells. Thus, these findings highlighted a novel role of ACC1 in controlling thymic iNKT cell development mediated by the control of cell survival.
Comparative genomic analysis reveals niche adaption of Lactobacillus acidophilus
Authors: Liu Xudong , Wu Zhinan , Hu Tongyuan , Lin Xiaoqian , Liang Hewei , Li Wenxi , Jin Xin , Xiao Liang , Fang Xiaodong , Zou Yuanqiang 
Published: December 2023

Abstract

Aims
Lactobacillus acidophilus has been extensively applied in plentiful probiotic products. Although several studies have been performed to investigate the beneficial characteristics and genome function of L. acidophilus, comparative genomic analysis remains scarce. In this study, we collected 74 L. acidophilus genomes from our gut bacterial genome collection and the public database and conducted a comprehensive comparative genomic analysis.

Methods and results
This study revealed the potential correlation of the genomic diversity and niche adaptation of L. acidophilus from different perspectives. The pan-genome of L. acidophilus was found to be open, with metabolism, information storage, and processing genes mainly distributed in the core genome. Phage- and peptidase-associated genes were found in the genome of the specificity of animal-derived strains, which were related to the adaptation of the animal gut. SNP analysis showed the differences of the utilization of vitamin B12 in cellular of L. acidophilus strains from animal gut and others.

Conclusions
This work provides new insights for the genomic diversity analysis of L. acidophilus and uncovers the ecological adaptation of the specific strains.
Potential of yeasts as biocontrol agents against Fusarium graminearum in vitro and on corn
Authors: de Oliveira Andressa Jacqueline , Ono Mario Augusto , Suguiura Igor Massahiro de Souza , Zucareli Claudemir , Garcia Emanueli Bastos , Olchanheski Luiz Ricardo , Ono Elisabete Yurie Sataque 
Published: December 2023

Abstract

Aims
The antifungal effect of the yeast species Kluyveromyces marxianus, Meyerozyma caribbica, and Wickerhamomyces anomalus was evaluated against two Fusarium graminearum strains (FRS 26 and FSP 27) in vitro and on corn seeds.

Methods and results
The antifungal effect of the yeasts against F. graminearum was evaluated using scanning electron microscopy and extracellular chitinase and glucanase production to further elucidate the biocontrol mode of action. In addition, the germination percentage and vigor test were investigated after applying yeast on corn seeds. All the yeast strains inhibited fungal growth in vitro (57.4%–100.0%) and on corn seeds (18.9%–87.2%). In co-culture with antagonistic yeasts, F. graminearum showed collapsed hyphae and turgidity loss, which could be related to the ability of yeasts to produce chitinases and glucanases. The three yeasts did not affect the seed corn germination, and W. anomalus and M. caribbica increased corn seed growth parameters (germination percentage, shoot and root length, and shoot dry weight).

Conclusion
Meyerozyma caribbica and W. anomalus showed satisfactory F. graminearum growth inhibition rates and did not affect seed growth parameters. Further studies are required to evaluate the application of these yeasts to the crop in the field.
Developing and evaluating pediatric phecodes (Peds-Phecodes) for high-throughput phenotyping using electronic health records
Authors: Grabowska Monika E , Van Driest Sara L , Robinson Jamie R , Patrick Anna E , Guardo Chris , Gangireddy Srushti , Ong Henry H , Feng QiPing , Carroll Robert , Kannankeril Prince J , Wei Wei-Qi 
Published: December 2023

Abstract

Objective
Pediatric patients have different diseases and outcomes than adults; however, existing phecodes do not capture the distinctive pediatric spectrum of disease. We aim to develop specialized pediatric phecodes (Peds-Phecodes) to enable efficient, large-scale phenotypic analyses of pediatric patients.

Materials and Methods
We adopted a hybrid data- and knowledge-driven approach leveraging electronic health records (EHRs) and genetic data from Vanderbilt University Medical Center to modify the most recent version of phecodes to better capture pediatric phenotypes. First, we compared the prevalence of patient diagnoses in pediatric and adult populations to identify disease phenotypes differentially affecting children and adults. We then used clinical domain knowledge to remove phecodes representing phenotypes unlikely to affect pediatric patients and create new phecodes for phenotypes relevant to the pediatric population. We further compared phenome-wide association study (PheWAS) outcomes replicating known pediatric genotype-phenotype associations between Peds-Phecodes and phecodes.

Results
The Peds-Phecodes aggregate 15 533 ICD-9-CM codes and 82 949 ICD-10-CM codes into 2051 distinct phecodes. Peds-Phecodes replicated more known pediatric genotype-phenotype associations than phecodes (248 vs 192 out of 687 SNPs, P &lt; .001).

Discussion
We introduce Peds-Phecodes, a high-throughput EHR phenotyping tool tailored for use in pediatric populations. We successfully validated the Peds-Phecodes using genetic replication studies. Our findings also reveal the potential use of Peds-Phecodes in detecting novel genotype-phenotype associations for pediatric conditions. We expect that Peds-Phecodes will facilitate large-scale phenomic and genomic analyses in pediatric populations.

Conclusion
Peds-Phecodes capture higher-quality pediatric phenotypes and deliver superior PheWAS outcomes compared to phecodes.
A bright triple transient that vanished within 50 min
Authors: Solano Enrique , Marcy Geoffrey W , Villarroel Beatriz , Geier Stefan , Streblyanska Alina , Lombardi Gianluca , Bär Rudolf E , Andruk Vitaly N 
Published: December 2023

ABSTRACT
We report on three optically bright, ∼16th mag, point sources within 10 arcsec of each other that vanished within 1 h, based on two consecutive exposures at Palomar Observatory on 1952 July 19 (POSS I Red and Blue). The three point sources have continued to be absent in telescope exposures during 71 yr with detection thresholds of ∼21st mag. We obtained two deep exposures with the 10.4-m Gran Telescopio Canarias on 2023 April 25 and 27 in r and g band, both reaching magnitude 25.5 (3σ). The three point sources are still absent, implying they have dimmed by more than 10 mag within an hour back in 1952. When bright in 1952, the most isolated transient source has a profile nearly the same as comparison stars, implying the sources are subarcsec in angular size and they exhibit no elongation due to movement. This triple transient has observed properties similar to other cases where groups of transients (‘multiple transients’) have appeared and vanished in a small region within a plate exposure. The explanation for these three transients and the previously reported cases remains unclear. Models involving background objects that are optically luminous for less than 1 h coupled with foreground gravitational lensing seem plausible. If so, a significant population of massive objects with structure serving as the lenses, to produce three images, are required to explain the subhour transients.
High dust content of a quiescent galaxy at z ∼ 2 revealed by deep ALMA observation
Authors: Lee Minju M , Steidel Charles C , Brammer Gabriel , Förster-Schreiber Natascha , Renzini Alvio , Liu Daizhong , Herrera-Camus Rodrigo , Naab Thorsten , Price Sedona H , Übler Hannah , Arriagada-Neira Sebastián , Magdis Georgios 
Published: December 2023

ABSTRACT
We report the detection of cold dust in an apparently quiescent massive galaxy (log (M⋆/M⊙) ≈ 11) at z ∼ 2 (G4). The source is identified as a serendipitous 2 mm continuum source in a deep ALMA observation within the field of Q2343-BX610, a z = 2.21 massive star-forming disc galaxy. Available multiband photometry of G4 suggests redshift of z ∼ 2 and a low specific star formation rate (sSFR), log (SFR/M⋆)[yr−1] ≈ −10.2, corresponding to ≈1.2 dex below the z = 2 main sequence (MS). G4 appears to be a peculiar dust-rich quiescent galaxy for its stellar mass (log (Mdust/M⋆) = −2.71 ± 0.26), with its estimated mass-weighted age (∼1–2 Gyr). We compile z ≳ 1 quiescent galaxies in the literature and discuss their age–ΔMS and log (Mdust/M⋆)–age relations to investigate passive evolution and dust depletion scale. A long dust depletion time and its morphology suggest morphological quenching along with less efficient feedback that could have acted on G4. The estimated dust yield for G4 further supports this idea, requiring efficient survival of dust and/or grain growth, and rejuvenation (or additional accretion). Follow-up observations probing the stellar light and cold dust peak are necessary to understand the implication of these findings in the broader context of galaxy evolutionary studies and quenching in the early universe.
The magnetically quiet solar surface dominates HARPS-N solar RVs during low activity
Authors: Lakeland Ben S , Naylor Tim , Haywood Raphaëlle D , Meunier Nadège , Rescigno Federica , Dalal Shweta , Mortier Annelies , Thompson Samantha J , Cameron Andrew Collier , Dumusque Xavier , López-Morales Mercedes , Pepe Francesco , Rice Ken , Sozzetti Alessandro , Udry Stéphane , Ford Eric , Ghedina Adriano , Lodi Marcello 
Published: December 2023

ABSTRACT
Using images from the Helioseismic and Magnetic Imager aboard the Solar Dynamics Observatory, we extract the radial velocity (RV) signal arising from the suppression of convective blueshift and from bright faculae and dark sunspots transiting the rotating solar disc. We remove these rotationally modulated magnetic-activity contributions from simultaneous RVs observed by the HARPS-N (High Accuracy Radial velocity Planet Searcher for the Northern hemisphere) solar feed to produce an RV time series arising from the magnetically quiet solar surface (the ‘inactive-region RVs’). We find that the level of variability in the inactive-region RVs remains constant over the almost 7-yr baseline and shows no correlation with well-known activity indicators. With an root-mean-square scatter of roughly 1 ${\rm m\, s}^{-1}$, the inactive-region RV time series dominates the total RV variability budget during the decline of solar cycle 24. Finally, we compare the variability amplitude and time-scale of the inactive-region RVs with simulations of supergranulation. We find consistency between the inactive-region RV and simulated time series, indicating that supergranulation is a significant contribution to the overall solar RV variability, and may be the main source of variability towards solar minimum. This work highlights supergranulation as a key barrier to detecting Earth twins.