bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heflikite, ideally Ca2(Al2Sc)(Si2O7)(SiO4)O(OH), the first scandium epidote-supergroup mineral from Jordanów Śląski, Lower Silesia, Poland and from Heftetjern, Tørdal, Norway
Authors: Pieczka Adam , Kristiansen Roy , Stachowicz Marcin , Dumańska-Słowik Magdalena , Gołębiowska Bożena , Sęk Mateusz P. , Nejbert Krzysztof , Kotowski Jakub , Marciniak-Maliszewska Beata , Szuszkiewicz Adam , Szełęg Eligiusz , Woźniak Krzysztof 
Published: January 2024

AbstractHeflikite, the first Sc-dominant epidote-supergroup mineral, was discovered in two occurrences. The holotype was found in a granitic pegmatite associated with rodingite-like calc-silicate rocks and metasomatised granitic bodies exposed in a serpentinite quarry at Jordanów Śląski near Sobótka, Lower Silesia, SW Poland. The cotype comes from the Heftetjern pegmatite, Tørdal region, Norway. The holotype is composed of (in wt.%): 35.69 SiO2, 0.22 TiO2, 21.98 Al2O3, 6.12 Sc2O3, 0.07 V2O3, 1.10 Fe2O3, 0.11 Y2O3, 1.55 La2O3, 4.05 Ce2O3, 0.31 Pr2O3, 1.53 Nd2O3, 0.40 Sm2O3, 0.11 EuO, 0.56 Gd2O3, 0.14 MnO, 3.56 FeO, 0.16 MgO, 19.16 CaO and 1.78 H2O(+)calc.; total 98.60. The cotype contains: 34.92 SiO2, 0.44 TiO2, 0.82 SnO2, 19.13 Al2O3, 4.79 Sc2O3, 1.96 Fe2O3, 2.55 La2O3, 7.39 Ce2O3, 0.48 Pr2O3, 0.67 Nd2O3, 0.12 EuO, 0.61 Gd2O3, 0.13 MnO, 5.97 FeO, 17.66 CaO and 1.73 H2O(+)calc.; total 99.37. The compositions correspond to the following empirical formulae: (Ca1.729Ce0.125La0.048Nd0.046Gd0.016Sm0.012Pr0.010Y0.005Eu2+0.003)Σ1.994[(Al2.182Sc0.449Fe3+0.070V3+0.005)Σ2.706(Fe2+0.251Mg0.020Mn0.010)Σ0.281Ti0.014]Σ3.001(Si3.006O11)O(OH) and (Ca1.644Ce0.235La0.082Nd0.021Gd0.018Pr0.015Eu2+0.004)Σ1.019[(Al1.958Sc0.362Fe3+0.128)Σ2.448(Fe2+0.434Mn0.009)Σ0.443(Ti0.029Sn0.029)Σ0.058]Σ2.949(Si3.033O11)O(OH), respectively, and to the ideal formula Ca2(Al2Sc)(Si2O7)(SiO4)O(OH). The crystal structure of the holotype was refined in the monoclinic system with an R1 index of 8.62%. The crystal-structure refinement indicates exclusively Si occupied T sites, Al occupied M1 and M2 sites, and a Ca occupied A1 site. The M3 site is filled predominantly by trivalent cations, mainly Sc3+, with divalent cations (mainly Fe2+) as minor occupants. The A2 site is filled mostly by Ca with minor amounts of rare earth elements (REE). The holotype heflikite crystallised from metasomatic fluids that infiltrated a contact between the granitic pegmatite and the surrounding rodingite-type calc-silicate rocks and serpentinites. The fluids that introduced Sc into the pegmatite could have been either hydrothermal or related to low-grade regional metamorphism that postdated the formation of the pegmatite. The cotype heflikite formed during the late-stage hydrothermal crystallisation of the Sc-enriched granitic pegmatite.
Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population
Authors: Lee David J. , El-Khoury Habib , Tramontano Angela C. , Alberge Jean-Baptiste , Perry Jacqueline , Davis Maya I. , Horowitz Erica , Redd Robert , Sakrikar Dhananjay , Barnidge David , Perkins Mark C. , Harding Stephen , Mucci Lorelei , Rebbeck Timothy R. , Ghobrial Irene M. , Marinac Catherine R. 
Published: January 2024

Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition of multiple myeloma with few known risk factors. The emergence of mass spectrometry (MS) for the detection of MGUS has provided new opportunities to evaluate its risk factors. In total, 2628 individuals at elevated risk for multiple myeloma were enrolled in a screening study and completed an exposure survey (PROMISE trial). Participant samples were screened by MS, and monoclonal proteins (M-proteins) with concentrations of ≥0.2 g/L were categorized as MS-MGUS. Multivariable logistic models evaluated associations between exposures and MS outcomes. Compared with normal weight (body mass index [BMI] of 18.5 to &lt;25 kg/m2), obesity (BMI of ≥30 kg/m2) was associated with MS-MGUS, adjusting for age, sex, Black race, education, and income (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.21-2.47; P = .003). High physical activity (≥73.5 metabolic equivalent of task (MET)-hours per week vs &lt;10.5 MET-hours per week) had a decreased likelihood of MS-MGUS (OR, 0.45, 95% CI, 0.24-0.80; P = .009), whereas heavy smoking and short sleep had increased likelihood of MS-MGUS (&gt;30 pack-years vs never smoker: OR, 2.19; 95% CI, 1.24-3.74; P = .005, and sleep &lt;6 vs ≥6 hours per day: OR, 2.11; 95% CI, 1.26-3.42; P = .003). In the analysis of all MS-detected monoclonal gammopathies, which are inclusive of M-proteins with concentrations of &lt;0.2 g/L, elevated BMI and smoking were associated with all MS-positive cases. Findings suggest MS-detected monoclonal gammopathies are associated with a broader range of modifiable risk factors than what has been previously identified. This trial was registered at www.clinicaltrials.gov as #NCT03689595.
Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression
Authors: Yu Fulong , Li Liang , Gu Yimei , Wang Song , Zhou Lianbang , Cheng Xiaohu , Jiang Heng , Huang Yang , Zhang Yingfeng , Qian Wenbao , Li Xianghua , Liu Zhining 
Published: January 2024

Abstract
Background
Lysine demethylase 5C (KDM5C) has been implicated in the development of several human cancers. This study aims to investigate the role of KDM5C in the progression of colorectal cancer (CRC) and explore the associated molecular mechanism.

Methods
Bioinformatics tools were employed to predict the target genes of KDM5C in CRC. The expression levels of KDM5C and prefoldin subunit 5 (PFDN5) in CRC cells were determined by RT-qPCR and western blot assays. The interaction between KDM5C, H3K4me3, and PFDN5 was validated by chromatin immunoprecipitation. Expression and prognostic values of KDM5C and PFDN5 in CRC were analyzed in a cohort of 72 patients. The function of KDM5C/PFDN5 in c-Myc signal transduction was analyzed by luciferase assay. Silencing of KDM5C and PFDN5 was induced in CRC cell lines to analyze the cell malignant phenotype in vitro and tumorigenic activity in nude mice.

Results
KDM5C exhibited high expression, while PFDN5 displayed low expression in CRC cells and clinical CRC samples. High KDM5C levels correlated with poor survival and unfavorable clinical presentation, whereas elevated PFDN5 correlated with improved patient outcomes. KDM5C mediated demethylation of H3K4me3 on the PFDN5 promoter, suppressing its transcription and thereby enhancing the transcriptional activity of c-Myc. KDM5C knockdown in CRC cells suppressed cell proliferation, migration and invasion, epithelial-mesenchymal transition, and tumorigenic activity while increasing autophagy and apoptosis rates. However, the malignant behavior of cells was restored by the further silencing of PFDN5.

Conclusion
This study demonstrates that KDM5C inhibits PFDN5 transcription, thereby activating c-Myc signal transduction and promoting CRC progression.
PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects
Authors: Kim Emma E. , Jang Chloe Soohyun , Kim Hakin , Han Buhm 
Published: January 2024

Abstract
Background
Meta-analysis is a statistical method that combines the results of multiple studies to increase statistical power. When multiple studies participating in a meta-analysis utilize the same public dataset as controls, the summary statistics from these studies become correlated. To solve this challenge, Lin and Sullivan proposed a method to provide an optimal test statistic adjusted for the correlation. This method quickly became the standard practice. However, we identified an unexpected power asymmetry phenomenon in this standard framework. This can lead to unbalanced power for detecting protective minor alleles and risk minor alleles.

Results
We found that the power asymmetry of the current framework is mainly due to the errors in approximating the correlation term. We then developed a meta-analysis method based on an accurate correlation estimator, called PASTRY (A method to avoid Power ASymmeTRY). PASTRY outperformed the standard method on both simulated and real datasets in terms of the power symmetry.

Conclusions
Our findings suggest that PASTRY can help to alleviate the power asymmetry problem. PASTRY is available at https://github.com/hanlab-SNU/PASTRY.
The level of partial pressure of carbon dioxide affects respiratory effort in COVID-19 patients undergoing pressure support ventilation with extracorporeal membrane oxygenation
Authors: Zhou Yuankai , Wang Xinchen , Du Wei , He Huaiwu , Wang Xiaoting , Cui Na , Long Yun 
Published: January 2024

Abstract
Background
Patients with COVID-19 undergoing pressure support ventilation (PSV) with extracorporeal membrane oxygenation (ECMO) commonly had high respiratory drive, which could cause self-inflicted lung injury. The aim of this study was to evaluate the influence of different levels of partial pressure of carbon dioxide(PaCO2) on respiratory effort in COVID-19 patients undergoing PSV with ECMO.

Methods
ECMO gas flow was downregulated from baseline (respiratory rate < 25 bpm, peak airway pressure < 25 cm H2O, tidal volume < 6 mL/kg, PaCO2 < 40 mmHg) until PaCO2 increased by 5 − 10 mmHg. The pressure muscle index (PMI) and airway pressure swing during occlusion (ΔPOCC) were used to monitor respiratory effort, and they were measured before and after enforcement of the regulations.

Results
Ten patients with COVID-19 who had undergone ECMO were enrolled in this prospective study. When the PaCO2 increased from 36 (36 − 37) to 42 (41–43) mmHg (p = 0.0020), there was a significant increase in ΔPOCC [from 5.6 (4.7–8.0) to 11.1 (8.5–13.1) cm H2O, p = 0.0020] and PMI [from 3.0 ± 1.4 to 6.5 ± 2.1 cm H2O, p < 0.0001]. Meanwhile, increased inspiratory effort determined by elevated PaCO2 levels led to enhancement of tidal volume from 4.1 ± 1.2 mL/kg to 5.3 ± 1.5 mL/kg (p = 0.0003) and respiratory rate from 13 ± 2 to 15 ± 2 bpm (p = 0.0266). In addition, the increase in PaCO2 was linearly correlated with changes in ΔPOCC and PMI (R2 = 0.7293, p = 0.0003 and R2 = 0.4105, p = 0.0460, respectively).

Conclusions
In patients with COVID-19 undergoing PSV with ECMO, an increase of PaCO2 could increase the inspiratory effort.
Quality of life and nutritional status in peritoneal dialysis patients: a cross-sectional study from Palestine
Authors: Ali Iyad , Haddad Dania , Soliman Mostafa A. , Al-Sabi Ahmed , Jebreen Kamel , Abuzahra Dana , Shrara Bakrieh , Ghanayem Diana , Natour Nihal , Hassan Mohanad , Alsedfy M. Yasser , Shellah Duha , Nawajah Inad 
Published: January 2024

Abstract
Background
End-stage renal disease (ESRD) is a growing cause of morbidity worldwide. Protein malnutrition is common among patients with ESRD. Peritoneal dialysis (PD) offers greater lifestyle flexibility and independence compared to the widely used treatments for ESRD. This study aimed to assess the nutritional status and the quality of life (QOL) of Palestinian patients undergoing PD, as well as the variables affecting these two outcomes.

Methods
A cross-sectional study was conducted on patients receiving PD at An-Najah National University Hospital, Palestine. The malnutrition-inflammation scale (MIS) was used to measure malnutrition, and the QOL score was evaluated using the Dutch WHOQOL-OLD module. Univariate and multivariate linear regressions were performed to check the association between the QOL and MIS scores.

Results
The study included 74 patients who were undergoing PD, with an average age of 50.5 ± 16.38. The majority of the patients were females. The study found a significant correlation between malnutrition and lower quality of life (QOL) scores, as measured by the WHOQOL-OLD questionnaire (p < 0.001). Furthermore, younger patients and those who had an occupation were more likely to report a good QOL (p = 0.01). Conversely, patients with pitting edema and diabetes were at higher risk of reporting a lower QOL (p < 0.001).

Conclusions
Given the elevated risk of malnutrition and diminished QOL among elderly patients, those with pitting edema, and individuals with diabetes, it is imperative to conduct thorough assessments for these groups. We strongly recommend that general practitioners, dietitians, and specialists collaborate to develop tailored programs and interventions to provide these patients with the focused care and attention they require.
Continuous versus intermittent bolus infusion of calcium in preterm infants receiving total parenteral nutrition: a randomized blind clinical trial
Authors: Shiva Siamak , Rezazadeh Khatereh , Amiraslanzadeh Asmar , Mehramuz Bahareh , Yeganehdoost Sadollah , Mahallei Majid 
Published: January 2024

Abstract
Background
Premature neonates need adequate nutritional support to provide sufficient essential nutrients for optimal growth. Calcium (Ca) is one of the important nutrients in parental nutrition support of premature infants. This study aimed to compare the effect of continuous and intermittent bolus infusion of Ca on the incidence of metabolic bone disease (MBD) in preterm infants.

Methods
This randomized double-blind clinical trial was conducted on ninety preterm infants in the NICU of Al-Zahra Hospital in Tabriz, Iran. The preterm infants were randomly allocated to either a continuous infusion group (received 4–5 ml/kg/day of Ca gluconate 10% by PN solution in a 24-h period) or an intermittent bolus administration group (received 1–2 ml/kg/day Ca gluconate 10% three to four times per day). Serial serum levels of Ca, phosphorous, alkaline phosphatase (ALP), vitamin D and parathyroid hormone (PTH) were assessed on the 7th day, 30th day and 45th day of life.

Results
A total of 78 infants completed the study. The serum ALP level on the 45th day after birth was 753.28 ± 304.59 IU/L and 988.2 ± 341.3 IU/L in the continuous infusion and intermittent bolus administration groups, respectively (P < 0.05). MBD in preterm infants with ALP levels above 900 IU/L on the 45th day of life was significantly lower in the continuous infusion group than in the intermittent bolus administration group (p < 0.05). The mean serum levels of calcium, phosphorus, vitamin D and PTH in 45-day-old infants were not significantly different between the two groups.

Conclusion
The MBD in preterm infants who received continuous infusion of Ca was lower than that in preterm infants who received intermittent bolus administration of Ca.

Trial registration
The Iranian Registry of Clinical Trials (http://www.irct.ir) with the identification No. IRCT20210913052466N1.
Barriers and facilitators to fulfilling the teaching assistant role from nursing students’ perspective: a qualitative study
Authors: Pashaeypoor Shahzad , Majdabadi Zahra Amrollah , Khanipour-Kencha Ali , Nikpeyma Nasrin 
Published: January 2024

Abstract
Background
Employing postgraduate students as Teaching Assistants (TA) has become a common practice in many higher education institutions and is part of a growing international trend for professional practice.

Objective
This study aimed to determine the barriers and facilitators to fulfilling the teaching assistant role from nursing students’ perspective.

Methodology
This qualitative-descriptive study was conducted in 2022 on teaching assistants in the Faculty of Nursing and Midwifery of Tehran University of Medical Sciences. 13 teaching assistants were selected by targeted sampling method with maximum variation. The inclusion criteria were 2nd-semester postgraduate nursing students and above, having experience as a teaching assistant, and willing to participate in the research. Data were collected through semi-structured individual interviews for 45 to 60 min until saturation was reached. Data analysis was done manually and using the framework analysis method with steps: Familiarization, Identifying a thematic framework, indexing, Charting, data synthesis, mapping, and interpretation. The trustworthiness of the study data was determined with the Lincoln and Guba criteria.

Results
Barriers to fulfilling the TAs’ role were divided into three main categories with nine subcategories: (1) Not accepting the teaching assistant as a clinical instructor (2) not being prepared to accept the TA role, and (3) improper planning of the TA plan. Facilitators are divided into two main categories with five subcategories: (1) internal motivation, and (2) empowering TAs.

Conclusion
To facilitate management processes in the field of education and to achieve educational goals, including improving the quality of education and better learning, planning and compiling instructions to create written job descriptions for teacher assistants should be done, also, with careful planning, steps should be taken to scientifically employ capable teacher assistants as young and motivated forces in education processes.
Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Authors: Li Wenli , Chen Yuansen , Li Duo , Meng Xiangyan , Liu Ziquan , Liu Yanqing , Fan Haojun 
Published: January 2024

AbstractBackgroundVenovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndrome (ARDS) in recent years. However, the role of hemoadsorption in ARDS patients requiring VV ECMO is unclear.MethodsTherefore, we conducted a systematic review to describe the effect of hemoadsorption on outcomes of ARDS patients requiring VV ECMO and elucidate the risk factors for adverse outcomes. We conducted and reported a systematic literature review based on the principles derived from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The systematic review searched Embase, CINHAL, and Pubmed databases for studies on ARDS patients receiving hemoadsorption and VV ECMO. The demographic data, clinical data and biological data of the patients were collected.ResultsWe ultimately included a total of 8 articles including 189 patients. We characterized the population both clinically and biologically. Our review showed most studies described reductions in inflammatory markers and fluid resuscitation drug dosage in ARDS patients with Coronavirus disease 2019 (COVID-19) or sepsis after hemoadsorption.ConclusionBecause most of the studies have the characteristics of high heterogeneity, we could only draw very cautious conclusions that hemoadsorption therapy may enhance hemodynamic stability in ARDS patients with COVID-19 or sepsis receiving VV ECMO support. However, our results do not allow us to draw conclusions that hemoadsorption could reduce inflammation and mortality. Prospective randomized controlled studies with a larger sample size are needed in the future to verify the role of hemoadsorption in ARDS patients requiring VV ECMO.
The involvement of α-synucleinopathy in the disruption of microglial homeostasis contributes to the pathogenesis of Parkinson’s disease
Authors: Miao Yongzhen , Meng Hongrui 
Published: January 2024

AbstractThe intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared pathological characteristics among neurodegenerative disorders collectively known as α-synucleinopathies, including Parkinson's disease (PD). Although the precise triggers of α-synucleinopathies remain unclear, recent findings indicate that disruption of microglial homeostasis contributes to the pathogenesis of PD. Microglia play a crucial role in maintaining optimal neuronal function by ensuring a homeostatic environment, but this function is disrupted during the progression of α-syn pathology. The involvement of microglia in the accumulation, uptake, and clearance of aggregated proteins is critical for managing disease spread and progression caused by α-syn pathology. This review summarizes current knowledge on the interrelationships between microglia and α-synucleinopathies, focusing on the remarkable ability of microglia to recognize and internalize extracellular α-syn through diverse pathways. Microglia process α-syn intracellularly and intercellularly to facilitate the α-syn neuronal aggregation and cell-to-cell propagation. The conformational state of α-synuclein distinctly influences microglial inflammation, which can affect peripheral immune cells such as macrophages and lymphocytes and may regulate the pathogenesis of α-synucleinopathies. We also discuss ongoing research efforts to identify potential therapeutic approaches targeting both α-syn accumulation and inflammation in PD.
The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling
Authors: Huang Mingyao , Yu Xiaoqin , Wang Qing , Jiang Zirong , Li Xiaofen , Chen Wei , Song Chuangui 
Published: January 2024

Abstract
Objective
The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy. Our research focused on investigating the role of CD155/TIGIT checkpoints in the progression of triple-negative breast cancer (TNBC).

Methods
We evaluated CD155 and TIGIT expression in TNBC tissues using both immunohistochemistry (IHC) and gene expression profiling. Our experiments, both in vivo and in vitro, provided evidence that inhibiting the CD155/TIGIT pathway reinstates the ability of CD8 + T cells to generate cytokines. To assess the impact of CD155/TIGIT signaling blockade, we utilized Glucose Assay Kits and Lactate Assay Kits to measure alterations in glucose and lactate levels within CD8 + T cells. We employed western blotting (WB) to investigate alterations in glycolytic-related proteins within the PI3K/AKT/mTOR pathways following the inhibition of CD155/TIGIT signaling.

Results
CD155 exhibits heightened expression within TNBC tissues and exhibits a negative correlation with the extent of infiltrating CD8 + T cells. Furthermore, patients with TNBC demonstrate elevated levels of TIGIT expression. Our findings indicate that the interaction between CD155 and TIGIT disrupts the glucose metabolism of CD8 + T cells by suppressing the activation of the PI3K/AKT/mTOR signaling pathway, ultimately leading to the reduced production of cytokines by CD8 + T cells. Both in vivo and in vitro experiments have conclusively demonstrated that the inhibition of CD155/TIGIT interaction reinstates the capacity of CD8 + T cells to generate cytokines. Moreover, in vivo administration of the blocking antibody against TIGIT not only inhibits tumor growth but also augments the functionality of CD8 + T lymphocytes.

Conclusions
Our research findings strongly suggest that CD155/TIGIT represents a promising therapeutic target for treating TNBC.