bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Efficiency of Myocardial Work Indexes in Determining Myocardial Viability in Patients With Acute St-elevation Myocardial Infarction (Stemi): a Diagnostic Test Study.
Authors: CUEVAS LUIS FERNANDO MORENO , ZERTUCHE DIANA ROMERO , MARQUEZ HORACIO GARCIA , RODRIGUEZ ERICK SANCHEZ , GUZMAN GABRIELA RODRIGUEZ , DUARTE SILVIA KARINA MARMOLEJO , CUENCA JESSICA JOCELYN AMADOR , MONTECINOS ALEJANDRO BECERRIL GONZALEZ , RUIZ LUIS ANTONIO MORENO 
Published: November 2023

Abstract

Purpose
To describe the diagnostic accuracy of myocardial work indices to identify myocardial viability in patients with STEMI and LVEF < 45%.
Methods
We studied 49 patients with STEMI and an ejection fraction < 45%. All of them underwent a myocardial viability study with cardiovascular magnetic resonance (CMR) using late gadolinium enhancement (viable tissue was defined as the presence of late enhancement < 50% of the myocardial thickness). At the same time, myocardial work indices were measured to identify the best cutoff point to determine viability, using CMR as the gold standard. We generated ROC curves and then calculated the sensitivity, specificity, and predictive values.
Results
Global constructive work had the best accuracy in the diagnosis of viability (AUC: 0.96. Specificity: 79%. Sensitivity: 97%, for a cutoff point > 786 mmHg%), compared with the Global Work Index (AUC: 0.96 Specificity: 91% Sensitivity: 79% at cutoff point > 664 mmHg%) and Global Myocardial Efficiency (AUC: 0.83 Specificity: 89% Sensitivity: 64% at a cutoff point > 75%); moreover, GCW was better than global longitudinal strain and biplanar ejection fraction of the left ventricle.
Conclusion
Myocardial work indices can detect viable myocardial tissue in patients with STEMI and left ventricular dysfunction with an acceptable degree of diagnostic accuracy.
A synchronous atmosphere-cryosphere-land response to climate on the northern Antarctic Peninsula since the mid-Holocene
Authors: Evangelista Heitor , Verkulich Sergei , Mavlyudov Bulat , Echer Mariza P. , Licinio Marcus Vinicius , Dercon Gerd , García-Rodríguez Felipe , Neto Arthur A. , Kusch Stephanie , Abuchacra Rodrigo C. , Oaquim Anna B.J. , Gonçalves Sérgio J. , Pushina Zinaida , Shimizu Marília H , Heiling Maria , Slaets Johanna , Resch Christian , Castillo Alejandra , Gruber Roman 
Published: November 2023

Abstract

West Antarctica plays a pivotal role in sea level rise in projected scenarios with global socioenvironmental and economic consequences. Therefore, describing its recent and past climate history and changes is essential for identifying the main climate controls and past responses. To better understand the climatic sensitivity of this region, we analyzed sedimentary records from newly surveyed proglacial lacustrine profiles dated from the middle Holocene to the present on the North Antarctic Peninsula. We combined atmosphere-glacier-land databases that evidenced a close coupling among these compartments during intense melting events. Our analyses furthermore suggest that a short Neoglacial phase from ∼2,000 kyr BP until the onset of the 20th century was possibly influenced by a combined long-term decline in total solar irradiance, Andean volcanism and ENSO.
Value of glycemic dispersion index in predicting major adverse cardiovascular events in diabetic patients with concomitant acute coronary syndrome
Authors: Shi R , Feng L , Xu WB , Ye D , Luo BB , Liu YM , Cao HY , Tang LT 
Published: November 2023

Abstract
Objective: This investigation aims to assess the predictive value of the glycemic dispersion index (GDI), calculated by incorporating glycated hemoglobin, fasting plasma glucose, and 2-hour postprandial plasma glucose, in predicting major adverse cardiovascular events (MACE) within a 12-month timeframe for diabetic patients with concomitant acute coronary syndrome (ACS).
Methods A total of 3261 diabetic patients diagnosed with ACS were selected from the Department of Cardiology, the Sixth Affiliated Hospital of Kunming Medical University, between January 2016 and July 2022. A thorough screening process was conducted, resulting in the inclusion of 512 patients based on the predefined exclusion criteria. Comprehensive clinical data and laboratory examination indicators were collected for all included patients. Subsequently, a follow-up was carried out for 12 months, with the last follow-up being concluded on July 31, 2023. During this period, the occurrence of MACE was meticulously recorded for each enrolled patient. Based on the GDI calculated for the enrolled patients, they were divided into quartile groups. A comparative analysis was performed to evaluate the clinical data and laboratory indicators among these groups. Additionally, the incidence of MACE in each quartile group was calculated. To further identify the risk factors associated with MACE in diabetic patients with concomitant ACS, COX proportional hazards regression analysis and Kaplan-Meier survival analysis were conducted. Finally, the cumulative risk of MACE over time was compared among the different study groups.
Results The patients included in the study were sorted into four groups, Q1, Q2, Q3, and Q4, according to their GDI levels, from lowest to highest. The respective proportions of MACE in the Q1 to Q4 groups were 10.16%, 12.50%, 15.63%, and 16.41%. GDI, STEMI, TC, TG, LDL, and hs-CRP independently predicted the hazards for MACE in diabetic individuals with ACS. The cumulative risk of MACE over time was considerably more significant in those with a GDI > 4.21 than those with a GDI ≤ 4.21.
Conclusion The elevated GDI is correlated with an augmented risk of MACE in diabetic patients with concomitant ACS, thereby serving as an early indicator for assessing the unfavorable clinical prognosis of patients.
Spatial model of groundwater contamination risks from pit-latrines to 2070: Case Study Malawi
Authors: Hinton Rebekah , Kalin Robert , Kanjaye Modesta , Mleta Prince , Macleod Christopher , Troldborg Mads 
Published: November 2023

Abstract
Pit-latrines are central to achieving SDG6, “clean water and sanitation for all”. Unless safely managed, pit-latrines result in groundwater contamination, which increases morbidity and mortality. Despite this, there have been no long-term spatial projections of future pit-latrine contamination risks. National survey data of over 100,000 water-points and 260,000 pit-latrines in Malawi was used to generate a novel, high-resolution model of pit-latrines from 2020–2070 under 5 population, and 3 sanitation policy, scenarios. The ‘business as usual’ model predicts a three-fold increase in the number of water-points at risk of microbial pit-latrine contamination between 2020–2070, with a seven-fold increase in the highest contamination risks. Current nitrogen loading into pit-latrines is comparable to national fertiliser application. The model predicts 8.2 mega-tonnes of faecal nitrogen will be disposed of into subsequently abandoned pit-latrines between 2020–2070. Guided intervention is necessary to prevent SDG6’s push for sanitation undermining its goal of clean water.
Detection and characterization of Deformed wing virus (DWV) in apiaries with stationary and migratory management in the province of Entre Ríos, Argentina
Authors: Gonzalez Fernanda Noemi , Raticelli Fabricio , Ferrufino Cecilia Gabriela , Fagúndez Guillermina , Rodriguez Graciela Adriana , Miño Samuel , Santos Maria Jose Dus 
Published: November 2023

Abstract

The deformed wing virus (DWV) is a highly prevalent pathogen that affects honeybees and is associated to colony losses. In Argentina, the Entre Rios province possesses a floral diversity that allows beekeepers to perform migratory or sedentary management. The aim of this work was to investigate the effect of both types of management on the prevalence and abundance of DWV and to characterize the DWV variant present in the study area. In migratory apiaries, 86.2% of the colonies gave a detectable result to DWV at the beginning of the season (September 2018), and 62% at the end of the season (April 2019). On the other hand, DWV was detected in 44.12% and 62% of sedentary samples, at the beginning and at the end of the season, respectively. The highest viral loads were obtained from migratory samples collected in September. DWV presence and abundance were associated with migratory management and the time of sampling. The virus was also detected in the brood, mites and pollen from the brood frame. Sequence analysis from migratory and sedentary samples revealed a unique DWV variant (DWV-A). Migratory activity has become a common approach to maximize honey production. However, this practice has negative consequences for colony health and susceptibility to DWV.
Comparison of factors affecting turnover intention by job field in biopharmaceutical industry in Korea: A questionnaire-based study
Authors: Cho Ae-Ryeo , Park Jungtae , Kwon Sun-Hong , Choi Jeong-min , Yu Wonsang Robert , Ha Dongmun , Lee Eui-Kyung 
Published: November 2023

Abstract

Background
Excessive turnover in the biopharmaceutical industry can negatively impact public health and corporate management. This study aims to determine the difference in turnover intention by job field and compare the factors affecting it.
Methods
An online self-report survey was administered to employees working in the production, sales/marketing, and clinical/regulatory affairs fields of biopharmaceutical companies in Korea from September 1 to October 31, 2020. The questionnaire addressed sociodemographic, constructs but also job, organization, and personal-related factors, as well as turnover intention. The difference in turnover intention by job field was confirmed by using the analysis of variance test. Multivariate regression analysis was performed to identify the factors affecting turnover intention by job field.
Results
A total of 529 employees responded to the questionnaire, and 500 cases were analyzed after discarding 29 cases with missing data. Turnover intention differed according to job field (p < 0.001), and production was the highest. In the production field, the higher both the satisfaction with the supervisor (β = -0.326, p-value = 0.005), the lower the turnover intention. Greater satisfaction with the work scope (β = -0.181, p-value = 0.01), salary (β = -0.169, p-value = 0.005) and corporate culture (β = -0.314, p < 0.001) factors showed low turnover intention for sales/marketing field, and the higher the satisfaction with the work scope (β = -0.350, p-value = 0.035), the lower the turnover intention for clinical/regulatory affairs field.
Conclusions
To reduce the turnover rate in the biopharmaceutical industry, it is necessary to develop policies that align with the unique needs of each job field. Companies should focus on increasing satisfaction with their supervisor for production field, and work scope for sales/marketing and clinical/regulatory affairs fields. Additionally, salary and corporate culture are important factors for sales/marketing field.
Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage of both eyes after Covid-19 infection: a case report
Authors: Wang Yifan , Chen Hong , Yuan Lifei , Fan Yijia , Liang Yilei , Zhang Haiyu , Dang Ziyao , Wang Lifei 
Published: November 2023

Abstract
Background
Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage is commonly observed in myopia with tilted optic disc. It presents with typical features on the fundus and follows a self-limiting course. However, due to its complex etiology, clinicians sometimes lack sufficient understanding of it which can easily lead to misdiagnosis or overtreatment. In this case report, we describe a rare case of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage in both.
Case presentation:
An 18-year-old female who has no past medical history experienced a sudden occlusion of the anterior visual field in the right eye for the past 2 days after a 5-day history of COVID-19 infection. The best corrected visual acuity is 0.5 in the right eye and 0.6 in the left eye. Optical coherence tomography (OCT) showed tilted optic discs in both eyes, bulged nasal optic discs, and the presence of strong reflective material under the parafoveal retina of the optic discs. Fundus fluorescein angiography (FFA) showed subretinal fluorescence occlusion above and nasolateral to the optic disc in the right eye, with hypofluorescence below the optic disc; the subretina below the optic disc was obscured by vitreous hemorrhage; hypofluorescence was seen in the optic disc region of the left eye.COVID-19 antigen was positive. The patient was in the early stage of the third COVID-19 infection when the disease occurred. We speculate that it may be related to it. After 5 months of conservative treatment, the patient's hemorrhage disappeared in both eyes and her best corrected visual acuity returned to normal.
Conclusions
Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage usually occurs in myopia with tilted optic disc. In most patients, the cause of the bleeding is unknown, but it can gradually resolve under clinical observation or conservative treatment.
Evaluation of grape genotypes for seedlessness and other agronomic traits as expressed under subtropical conditions for their potential role as donor parents
Authors: Jadhav Amol Kailas , Singh Sanjay Kumar , Verma Mahendra Kumar , Srivas Manish , Kumar Chavlesh , Mhetre Vishal Balasaheb 
Published: November 2023

Abstract

The present investigation was conducted from 2021 to 2022 in subtropical north India under New Delhi conditions by evaluating 12 grape accessions to assess the phenotypic and genetic variability across various horticultural traits. Notably, the genotypes exhibited significant variations in bunch weight, size, density, and berry traits, such as weight, shape, and seed presence. Seedless grapes, in particular, demonstrated superior bunch weight and size, with bunch weight ranging from 94.10 g (genotype Pearl of Csaba) to 325.67 g (genotype Perlette) and substantial variations in bunch size, too. For berry characteristics, the range extended from 1.37 g (genotype Beauty Seedles) to 3.57 g (genotype Pusa Aditi), with seeded genotypes displaying the largest berries. Physio-chemical analysis indicated that seedless grapes typically had higher total soluble solids (TSS) and acidity, although exceptions existed among the individual genotypes. The new hybrid genotype Pusa Purple Seedless exhibited the highest TSS (19.96 0B), while Beauty seedless had the lowest TSS (16.08 0B), with significant variations in pulp acidity and juice percentage across the genotypes. Based on seed or seed trace fresh weight anaysis, progenies were classified into four classes: completely seedless, semi-seedless, semi-seeded, and completely seeded. These categories were defined by the number of seed remnants per berry (ranging from 0.03 to 2.25), dry matter percentage (ranging from 30.82 to 60.53%), and average fresh seed trace weights (13.10, to 45.40 mg). Additionally, phenotypic and genetic correlations demonstrated positive associations between berry and seed traits with correlation coefficients ranging from r = 0.67 to 0.93 for specific traits. However, some negative correlations (r = -0.21 to -0.90) between berry and bunch size, TSS, Titratable acidity, and juice content were observed with certain traits. Principal Component Analysis identified key traits contributing to genetic diversity, which can be a valuable for seedless breeding programs in sub-tropical regions of India.
Effect of microalgae feed supplementation on growth performance and feeding efficiency of tilapia fry
Authors: Sorokin Boris , Gusev Evgeniy , Namsaraev Zorigto , Emelianova Anna , Patova Elena , Novakovskaya Irina , Vinokurov Vladimir , Kuzmin Denis 
Published: November 2023

Abstract

Search for novel best-performing starter feed ingredients is one of the main challenges of modern aquaculture industry. The goal of this article was to evaluate the effect of microalgae supplementation enriched with omega-3 polyunsaturated eicosapentaenoic acid and powerful antioxidant fucoxanthin on grows and performance of Red tilapia fry (Oreochromis mossambicus × Oreochromis niloticus). We formulated three experimental diets, using two strains of microalgae from our culture collection – Vischeria magna (Petersen) Kryvenda, Rybalka, Wolf & Friedl SBV-108 (class Eustigmatophyceae), rich with eicosapentaenoic acid and Mallomonas furtiva Gusev, Certnerová, Škaloudová & Škaloud SBV-13 (class Chrysophyceae), rich with fucoxanthin – and their combination. Vischeria magna SBV-108 is a new strain whose biochemical properties and growth characteristics have not been previously studied. Coppens Supreme-15 was used as control diet. The best performing was omega-3 enriched Diet 1 (10% w/w Vischeria magna), that significantly (P < 0.05) overperformed control feed on absolute growth, average growth, specific growth rate, feed conversion rate, protein efficiency ratio, protein productive value and energy productive value. Diet 3 (5% w/w Vischeria magna and 5% w/w Mallomonas furtiva) and Diet 2 (10% w/w Mallomonas furtiva) were not significantly different from control at most parameters. Generally, supplementation of feed with microalgae rich in omega-3 eicosapentaenoic acid significantly improved Red tilapia fry growth parameters and overall feed performance, while supplementation of feed with microalgae rich in antioxidant fucoxanthin was not beneficial compared to control.
Low expression of Elovl6 may involve in fat loss in white adipose tissue of cancer-associated cachexia
Authors: Jin Chenyang , Wang Shuangjie , Sui Xiangyu , Meng Qingyang , Wu Guohao 
Published: November 2023

Abstract
Background: Cancer-associated cachexia (CAC) arises from malignant tumors and leads to a debilitating wasting syndrome. In the pathophysiology of CAC, the depletion of fat performs a significant function. The mechanism of CAC-induced fat loss includes the enhancement of lipolysis, inhibition of lipogenesis, and browning of white adipose tissue (WAT), however, few lipid-metabolic enzymes have been reported to be involved in CAC. This study hypothesized that Elovl6, a critical enzyme for elongation of fatty acids, may involve in fat loss in CAC.
Method: Transcriptome sequencing technology was employed to identify CAC-related genes in the WAT of a CAC rodent model. Then the expression level of Elovl6 and fatty acid composition were analyzed in a large clinical sample. Elovl6 was knocked down in 3T3-L1 mouse preadipocytes to compare with wild-type 3T3-L1 cells treated with tumor cell-conditioned medium.
Result: In the WAT of patients with CAC, a significant decrease in the expression of Elovl6 was found, which correlates with the extent of body mass reduction in a linear relationship. Gas chromatographic analysis revealed an augmentation in palmitic acid (C16:0) and a reduction in linoleic acid (C18:2n6c) content in those tissue samples. Treating with tumor cell-conditioned medium, 3T3-L1 mouse preadipocytes showed a decrease of Elov16, and Elovl6-knockdown cells demonstrated reduced pre-adipocyte differentiation and lipogenesis. Likewise, the knockdown of Elovl6 in 3T3-L1 cells exhibited a significant rise in palmitic acid (C16:0) and a remarkable decrease in oleic acid (C18:1n9c) content.
Conclusion: Overall, the expression of Elovl6 was diminished in the WAT of CAC patients. The decreased expression of Elovl6 might lead to fat loss in CAC by potentially altering the fatty acid composition in adipocytes. These findings suggest that Elovl6 may be used as a valuable biomarker for early diagnosis of CAC, and hold promise as a target for future therapies.
Unravelling the Relationship between Obesity, Density, Accessibility to Public Transport and Green Spaces in Babol City
Authors: Shahmiri Mojtaba Shahabi , Khatami Seyed Mahdi , Javanian Mostafa 
Published: November 2023

Abstract
Due to the high rates of obesity and the lack of research on how the built environment contributes to obesity in Iran, this study aimed to investigate the relationship between density, accessibility to public transport and green spaces, obesity, and related diseases in Babol. Logistic regression was used to analyze data on health indicators such as body mass index (BMI), blood pressure, and diabetes, as well as environmental indicators including population density, residential density, accessibility to bus and taxi stations, the number of stations, the proximity to green spaces, and their proportion. The study found that living in areas with a density of over 120 people per square kilometer reduces the likelihood of being overweight or obese compared to areas with a density of 100 to 120 people. Access to green spaces within a 200-meter radius did not show a significant association with diseases. There was a weak negative relationship between the number of public transportation stations at different distances and body mass index, indicating lower levels of overweight and obesity. Changing from neighborhoods with lower residential densities to higher residential densities reduced the likelihood of developing heart disease and heart disease by about 74% and 44.4%, respectively. The presence of green spaces in neighborhoods had a weak correlation with physical activity and the reduction of obesity and related diseases. Increasing the number of taxi and bus stations from one to three within a 400-meter radius significantly reduced the likelihood of developing high blood pressure by approximately 70% and diabetes by 56.5% within a 200-meter radius. Living within a distance of less than 150 meters from the nearest public transportation station or nodal points was associated with a 51.3% lower probability of developing high blood pressure compared to living within a distance of 300 to 500 meters from public transportation stations.
Tailored Nanofluid Formulations: Enhancing Crude Oil Thermophysical Properties for Improved EOR Processes through MWCNTs and SDS Integration
Authors: Bagheri Hamid , Mousavi Seyed Borhan , Nami Shamin Hosseini , Heris Saeed Zeinali 
Published: November 2023

Abstract
This research delved into the effects of introducing multi-walled carbon nanotubes (MWCNTs) and sodium dodecyl sulfate (SDS) into crude oil with an anionic base, aiming to enhance its thermophysical attributes in the EOR process. The investigation encompassed a range of properties, including interfacial tension, viscosity, density, and electrical conductivity, measured using an LV rheometer with spindle 18. Various ratios of MWCNTs and SDS were mixed with the crude oil to evaluate their impacts. The study uncovered that the 1:1 ratio of MWCNTs to SDS achieved a noteworthy 10% reduction in interfacial tension while minimally affecting viscosity, showing promise for practical applications. Temperature had diverse effects on viscosity and interfacial tension, displaying fluctuating trends. The highest observed result was a substantial 190% viscosity increase at 40°C with a 2:1 ratio, whereas the lowest was a slight − 0.81% density change at 60°C for the 1:1 ratio. Additionally, interfacial tension consistently decreased over time for all ratios at various temperatures, with the most significant reductions observed at 40°C and 60°C, particularly for the 1:2 and 1:1 ratios. Furthermore, adding MWCNTs and SDS led to a remarkable drop in electrical conductivity, indicating a substantial decrease in salt content within the crude oil. However, it was noted that higher MWCNT concentrations might not be cost-effective, emphasizing the importance of optimizing additive ratios for a balance between performance and economic viability. This study highlights the potential of tailored nanofluid formulations to improve the thermophysical properties of crude oil, potentially enhancing extraction and refining processes.