bluuebunny/crossref_metadata_2025_split huggingface dataset:
NIR‐II Photoacoustic Imaging‐Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma
Authors: Zeng Silue , Chen Jingqin , Gao Rongkang , Chen Rui , Xue Qiang , Ren Yaguang , Liu Liangjian , Tang Chuanyu , Hu Haoyu , Zeng Ning , Wen Sai , Zhang Hai , Liu Chengbo , Fang Chihua 
Published: November 2023

AbstractHypoxia, a prominent hallmark of hepatocellular carcinoma (HCC), undermines curative outcomes, elevates recurrence rates, and fosters metastasis, particularly during photodynamic therapy (PDT) in clinical settings. Studies indicate that alleviating tumor hypoxia enhances PDT efficacy. However, persistent challenges, including suboptimal oxygen delivery efficiency and absence of real‐time feedback on blood oxygen fluctuations during PDT, considerably impede therapeutic efficacy in tumor treatment. This study addresses these issues using near‐infrared‐II (NIR‐II) photoacoustic (PA) imaging for tumor‐targeted oxygen delivery and controlled release. For this purpose, a biomimetic oxygen delivery system designated BLICP@O2 is developed, which utilizes hybrid tumor cell membranes and thermosensitive liposomes as oxygen carriers, incorporating the NIR‐II dye IR1048, photosensitizer chlorin e6 (Ce6), and perfluorohexane. Upon sequential irradiation at 1064 and 690 nm, BLICP@O2 exhibits significant photothermal and photodynamic effects. Photothermal heating triggers oxygen release, enhancing the photodynamic effect of Ce6. Blood oxygen changes during PDT are tracked by multispectral PA imaging. Enhanced PDT efficacy, mediated by hypoxia relief, is convincingly demonstrated both in vitro and in vivo. This work presents an imaging‐guided, dual‐wavelength programmed cascaded treatment strategy for tumor‐targeted oxygen delivery and controlled release, with real‐time efficacy monitoring using PA imaging, offering valuable insights for overcoming challenges in PDT‐based cancer therapy.
Recycled Tandem Catalysts Promising Ultralow Overpotential Li‐CO2 Batteries
Authors: Lu Bingyi , Min Zhiwen , Xiao Xiao , Wang Boran , Chen Biao , Lu Gongxun , Liu Yingqi , Mao Rui , Song Yanze , Zeng Xian‐Xiang , Sun Yuanmiao , Yang Jinlong , Zhou Guangmin 
Published: November 2023

AbstractLithium‐carbon dioxide (Li‐CO2) batteries are regarded as a prospective technology to relieve the pressure of greenhouse emissions but are confronted with sluggish CO2 redox kinetics and low energy efficiency. Developing highly efficient and low‐cost catalysts to boost bidirectional activities is craved but remains a huge challenge. Herein, derived from the spent lithium‐ion batteries, a tandem catalyst is subtly synthesized and significantly accelerates the CO2 reduction and evolution reactions (CO2RR and CO2ER) kinetics with an in‐built electric field (BEF). Combining with the theoretical calculations and advanced characterization techniques, this work reveals that the designed interface‐induced BEF regulates the adsorption/decomposition of the intermediates during CO2RR and CO2ER, endowing the recycled tandem catalyst with excellent bidirectional activities. As a result, the spent electronics‐derived tandem catalyst exhibits remarkable bidirectional catalytic performance, such as an ultralow voltage gap of 0.26 V and an ultrahigh energy efficiency of 92.4%. Profoundly, this work affords new opportunities to fabricate low‐cost electrocatalysts from recycled spent electronics and inspires fresh perceptions of interfacial regulation including but not limited to BEF to engineer better Li‐CO2 batteries.
Fluorescent Switchable Surfaces Based on Quantum Dots Modified With Redox‐Active Molecules
Authors: Campos‐Lendinez Ángel , Muñoz Jose , Crivillers Núria , Mas‐Torrent Marta 
Published: November 2023

AbstractBy combining the switching ability of redox molecules with the unique fluorescence properties of quantum dots (QDs), a robust electrochemical fluorescence switch is developed here. This is realized by grafting CdSe/ZnS QDs on transparent indium tin oxide (ITO) substrates and, subsequently, modifying them with a Ferrocene (Fc) molecular monolayer. The application of oxidation/reduction voltage pulses to tune the Fc redox state leads to the tuning of the surface fluorescence output. Interestingly, the ON/OF ratio can be enhanced by reducing the distance between the redox active unit and the QD due to a more efficient electronic coupling. Remarkably, by defining a mixed‐valence state, a ternary switch has also been achieved. It is highlighted that the QD surface immobilization is key to realize this switch to avoid aggregation and fluorescence quenching in suspension. Hence, an efficient and versatile novel route to fabricate robust fluorescent redox switches is demonstrated, opening a wide avenue of possibilities to be explored in the field of sensing and information storage.
Plasmonic Nano‐Rotamers with Programmable Polarization‐Resolved Coloration
Authors: Kim Juhwan , Han Jang‐Hwan , Kim Hyun Min , Lee Tung‐Chun , Jeong Hyeon‐Ho 
Published: November 2023

Abstract3D‐shaped artificial Mg nano‐rotamers with a programmable dihedral angle between two plasmonic arms, designed to exhibit both programmable linear and circular polarization properties, are presented. The nanoscale physical shadow growth technique offers precise control over the angular alignment in these nanostructures with 1° angular precision, thus controlling their symmetry from achiral C2v and C2h to chiral C2. As a result, they give rise to a wide range of polarization‐resolved coloration, spanning from invisible to visible colors with 46% transmission contrast for linear polarization while exhibiting 0.08 g‐factor in visible for circular polarization. These nano‐rotamers hold great potential for various applications in adaptive photonic filters, memory, and anticounterfeiting devices, benefiting from their tunable plasmonic properties.
Synthetic Cells Revisited: Artificial Cell Construction Using Polymeric Building Blocks
Authors: Maffeis Viviana , Heuberger Lukas , Nikoletić Anamarija , Schoenenberger Cora‐Ann , Palivan Cornelia G. 
Published: November 2023

AbstractThe exponential growth of research on artificial cells and organelles underscores their potential as tools to advance the understanding of fundamental biological processes. The bottom–up construction from a variety of building blocks at the micro‐ and nanoscale, in combination with biomolecules is key to developing artificial cells. In this review, artificial cells are focused upon based on compartments where polymers are the main constituent of the assembly. Polymers are of particular interest due to their incredible chemical variety and the advantage of tuning the properties and functionality of their assemblies. First, the architectures of micro‐ and nanoscale polymer assemblies are introduced and then their usage as building blocks is elaborated upon. Different membrane‐bound and membrane‐less compartments and supramolecular structures and how they combine into advanced synthetic cells are presented. Then, the functional aspects are explored, addressing how artificial organelles in giant compartments mimic cellular processes. Finally, how artificial cells communicate with their surrounding and each other such as to adapt to an ever‐changing environment and achieve collective behavior as a steppingstone toward artificial tissues, is taken a look at. Engineering artificial cells with highly controllable and programmable features open new avenues for the development of sophisticated multifunctional systems.
Visualization of Confined Electrons at Grain Boundaries in a Monolayer Charge‐Density‐Wave Metal
Authors: Chen Yaoyao , Zhang Yu , Wang Wei , Song Xuan , Jia Liang‐Guang , Zhang Can , Zhou Lili , Han Xu , Yang Hui‐Xia , Liu Li‐Wei , Si Chen , Gao Hong‐Jun , Wang Ye‐Liang 
Published: November 2023

Abstract1D grain boundaries in transition metal dichalcogenides (TMDs) are ideal for investigating the collective electron behavior in confined systems. However, clear identification of atomic structures at the grain boundaries, as well as precise characterization of the electronic ground states, have largely been elusive. Here, direct evidence for the confined electronic states and the charge density modulations at mirror twin boundaries (MTBs) of monolayer NbSe2, a representative charge‐density‐wave (CDW) metal, is provided. The scanning tunneling microscopy (STM) measurements, accompanied by the first‐principles calculations, reveal that there are two types of MTBs in monolayer NbSe2, both of which exhibit band bending effect and 1D boundary states. Moreover, the intrinsic CDW signatures of monolayer NbSe2 are dramatically suppressed as approaching an isolated MTB but can be either enhanced or suppressed in the MTB‐constituted confined wedges. Such a phenomenon can be well explained by the MTB‐CDW interference interactions. The results reveal the underlying physics of the confined electrons at MTBs of CDW metals, paving the way for the grain boundary engineering of the functionality.
Hollow Spherical Heterostructured FeCo‐P Catalysts Derived from MOF‐74 for Efficient Overall Water Splitting
Authors: Jiang Hualin , Zhao Zhe , Li Gang , Wang Mengxue , Chen Pinghua , Liu Xiaotian , Tu Xinman , Hu Yitian , Shen Zhen , Wu Yirou 
Published: November 2023

AbstractThe design of catalysts with tunable active sites in heterogeneous interface structures is crucial for addressing challenges in the water‐splitting process. Herein, a hollow spherical heterostructure FeCo‐P is successfully prepared by hydrothermal and phosphorization methods. This hollow structure, along with the heterogeneous interface between Co2P and FeP, not only facilitates the exposure of more active sites, but also increases the contact area between the catalyst and the electrolyte, as well as shortens the distance for mass/electron transfer. This enhancement promotes electron transfer to facilitate water decomposition. FeCo‐P exhibits excellent hydrogen evolution (HER) and oxygen evolution (OER) performance when reaching @ 10 mA cm−2 in 1 mol L−1 KOH, with overpotentials of 131/240 mV for HER/OER. Furthermore, when FeCo‐P is used as both the cathode and anode for overall water splitting (OWS), it only requires low voltages of 1.49, 1.55, and 1.57 V to achieve CDs of 10, 100, and 300 mA cm−2, respectively. Density functional theory calculations indicate that constructing a Co2P and FeP heterogeneous interface with good lattice matching can facilitate electron redistribution, thereby enhancing the electrocatalytic performance of OWS. This work opens up new possibilities for the rational design of efficient water electrolysis catalysts derived from MOFs.
Gelatin methacryloyl granular scaffolds for localized mRNA delivery
Authors: Carvalho Bruna Gregatti , Nakayama Aya , Miwa Hiromi , Han Sang Won , de la Torre Lucimara Gaziola , Di Carlo Dino , Lee Junmin , Kim Han‐Jun , Khademhosseini Ali , de Barros Natan Roberto 
Published: November 2023

AbstractMessenger RNA (mRNA) therapy is the intracellular delivery of mRNA to produce desired therapeutic proteins. Developing strategies for local mRNA delivery is still required where direct intra‐articular injections are inappropriate for targeting a specific tissue. The mRNA delivery efficiency depends on protecting nucleic acids against nuclease‐mediated degradation and safe site‐specific intracellular delivery. Herein, novel mRNA‐releasing matrices based on RGD‐moiety‐rich gelatin methacryloyl (GelMA) microporous annealed particle (MAP) scaffolds are reported. GelMA concentration in aerogel‐based microgels (µgels) produced through a microfluidic process, MAP stiffnesses, and microporosity are crucial parameters for cell adhesion, spreading, and proliferation. After being loaded with mRNA complexes, MAP scaffolds composed of 10% GelMA µgels display excellent cell viability with increasing cell infiltration, adhesion, proliferation, and gene transfer. The intracellular delivery is achieved by the sustained release of mRNA complexes from MAP scaffolds and cell adhesion on mRNA‐releasing scaffolds. These findings highlight that hybrid systems can achieve efficient protein expression by delivering mRNA complexes, making them promising mRNA‐releasing biomaterials for tissue engineering.
Synergistic promotions of K doping on CO2 capture and in situ conversion
Authors: Xie Zhicheng , Shao Bin , Sun Zheyi , Shi Yaqi , Gao Zihao , Li Su , Li Jingkun , Li Yi , Liu Honglai , Hu Jun 
Published: November 2023

AbstractThe integrated CO2 capture and conversion (iCCC) technology has been recognized as a promising strategy for upcycling the emitted CO2 into artificial carbon sequestration but still demands highly efficient dual functional materials (DFMs). We develop an efficient iCCC process of the integrated lithium‐looping (LiL) and reverse water gas shift reaction through deeply understanding K doping in the novel Kx‐Li4SiO4@Niy DFMs. The appropriate K doping enables the fast diffusion of CO2 and H2 into the bulk DFMs through forming LiKCO3 surface eutectic layer as well as strongly interacts with catalyst Ni to generate new medium basic sites for synergistic promotions of CO2 capture and in situ conversion. More importantly, after the pelletization, the LP‐K0.2‐Li4SiO4@Ni10 DFM (20–40 mesh) avoids the agglomeration and achieves an excellent and stable iCCC cycle performance, with CO2 capture capacity of 3.8 mmol/g, CO2 conversion efficiency of 90%, and CO selectivity close to 100% at 550°C in one fixed‐bed column.
Sex‐specific genetic architecture of late‐life memory performance
Authors: Eissman Jaclyn M. , Archer Derek B. , Mukherjee Shubhabrata , Lee Michael L. , Choi Seo‐Eun , Scollard Phoebe , Trittschuh Emily H. , Mez Jesse B. , Bush William S. , Kunkle Brian W. , Naj Adam C. , Gifford Katherine A. ,   The Alzheimer's Disease Neuroimaging Initiative (ADNI) | Alzheimer's Disease Genetics Consortium (ADGC) | The Alzheimer's Disease Sequencing Project (ADSP), Cuccaro Michael L. , Cruchaga Carlos , Pericak‐Vance Margaret A. , Farrer Lindsay A. , Wang Li‐San , Schellenberg Gerard D. , Mayeux Richard P. , Haines Jonathan L. , Jefferson Angela L. , Kukull Walter A. , Keene C. Dirk , Saykin Andrew J. , Thompson Paul M. , Martin Eden R. , Bennett David A. , Barnes Lisa L. , Schneider Julie A. , Crane Paul K. , Hohman Timothy J. , Dumitrescu Logan 
Published: November 2023

AbstractBACKGROUNDWomen demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear.METHODSWe conducted the largest sex‐aware genetic study on late‐life memory to date (Nmales = 11,942; Nfemales = 15,641). Leveraging harmonized memory composite scores from four cohorts of cognitive aging and AD, we performed sex‐stratified and sex‐interaction genome‐wide association studies in 24,216 non‐Hispanic White and 3367 non‐Hispanic Black participants.RESULTSWe identified three sex‐specific loci (rs67099044—CBLN2, rs719070—SCHIP1/IQCJ‐SCHIP), including an X‐chromosome locus (rs5935633—EGL6/TCEANC/OFD1), that associated with memory. Additionally, we identified heparan sulfate signaling as a sex‐specific pathway and found sex‐specific genetic correlations between memory and cardiovascular, immune, and education traits.DISCUSSIONThis study showed memory is highly and comparably heritable across sexes, as well as highlighted novel sex‐specific genes, pathways, and genetic correlations that related to late‐life memory.Highlights
Demonstrated the heritable component of late‐life memory is similar across sexes.
Identified two genetic loci with a sex‐interaction with baseline memory.
Identified an X‐chromosome locus associated with memory decline in females.
Highlighted sex‐specific candidate genes and pathways associated with memory.
Revealed sex‐specific shared genetic architecture between memory and complex traits.
Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease
Authors: Archer Derek B. , Eissman Jaclyn M. , Mukherjee Shubhabrata , Lee Michael L. , Choi Seo‐Eun , Scollard Phoebe , Trittschuh Emily H. , Mez Jesse B. , Bush William S. , Kunkle Brian W. , Naj Adam C. , Gifford Katherine A. ,   The Alzheimer's Disease Neuroimaging Initiative (ADNI),   Alzheimer's Disease Genetics Consortium (ADGC),   The Alzheimer's Disease Sequencing Project (ADSP), Cuccaro Michael L. , Pericak‐Vance Margaret A. , Farrer Lindsay A. , Wang Li‐San , Schellenberg Gerard D. , Mayeux Richard P. , Haines Jonathan L. , Jefferson Angela L. , Kukull Walter A. , Keene C. Dirk , Saykin Andrew J. , Thompson Paul M. , Martin Eden R. , Bennett David A. , Barnes Lisa L. , Schneider Julie A. , Crane Paul K. , Dumitrescu Logan , Hohman Timothy J. 
Published: November 2023

AbstractINTRODUCTIONAlthough large‐scale genome‐wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline.METHODSWe conducted a cross‐ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts.RESULTSWe found high heritability for two ancestry backgrounds. Further, we found a novel ancestry locus for memory decline on chromosome 4 (rs6848524) and three loci in the non‐Hispanic Black ancestry group for memory performance on chromosomes 2 (rs111471504), 7 (rs4142249), and 15 (rs74381744). In our gene‐level analysis, we found novel genes for memory decline on chromosomes 1 (SLC25A44), 11 (BSX), and 15 (DPP8). Memory performance and memory decline shared genetic architecture with AD‐related traits, neuropsychiatric traits, and autoimmune traits.DISCUSSIONWe discovered several novel loci, genes, and genetic correlations associated with late‐life memory performance and decline.Highlights
Late‐life memory has high heritability that is similar across ancestries.
We discovered four novel variants associated with late‐life memory.
We identified four novel genes associated with late‐life memory.
Late‐life memory shares genetic architecture with psychiatric/autoimmune traits.
The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease
Authors: Dalmasso Maria Carolina , de Rojas Itziar , Olivar Natividad , Muchnik Carolina , Angel Bárbara , Gloger Sergio , Sanchez Abalos Mariana Soledad , Chacón María Victoria , Aránguiz Rafael , Orellana Paulina , Cuesta Carolina , Galeano Pablo , Campanelli Lorenzo , Novack Gisela Vanina , Martinez Luis Eduardo , Medel Nancy , Lisso Julieta , Sevillano Zulma , Irureta Nicolás , Castaño Eduardo Miguel , Montrreal Laura , Thoenes Michaela , Hanses Claudia , Heilmann‐Heimbach Stefanie , Kairiyama Claudia , Mintz Inés , Villella Ivana , Rueda Fabiana , Romero Amanda , Wukitsevits Nancy , Quiroga Ivana , Gona Cristian , Lambert Jean‐Charles , Solis Patricia , Politis Daniel Gustavo , Mangone Carlos Alberto , Gonzalez‐Billault Christian , Boada Mercè , Tàrraga Lluís , Slachevsky Andrea , Albala Cecilia , Fuentes Patricio , Kochen Silvia , Brusco Luis Ignacio , Ruiz Agustín , Morelli Laura , Ramírez Alfredo 
Published: November 2023

AbstractINTRODUCTIONGenome‐wide association studies (GWAS) are fundamental for identifying loci associated with diseases. However, they require replication in other ethnicities.METHODSWe performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Chile. We combined our results with those from the European Alzheimer and Dementia Biobank (EADB) in a meta‐analysis and tested their genetic risk score (GRS) performance in this admixed population.RESULTSWe detected apolipoprotein E ε4 as the single genome‐wide significant signal (odds ratio = 2.93 [2.37–3.63], P = 2.6 × 10−23). The meta‐analysis with EADB summary statistics revealed four new loci reaching GWAS significance. Functional annotations of these loci implicated endosome/lysosomal function. Finally, the AD‐GRS presented a similar performance in these populations, despite the score diminished when the Native American ancestry rose.DISCUSSIONWe report the first GWAS on AD in a population from South America. It shows shared genetics modulating AD risk between the European and these admixed populations.Highlights
This is the first genome‐wide association study on Alzheimer's disease (AD) in a population sample from Argentina and Chile.
Trans‐ethnic meta‐analysis reveals four new loci involving lysosomal function in AD.
This is the first independent replication for TREM2L, IGH‐gene‐cluster, and ADAM17 loci.
A genetic risk score (GRS) developed in Europeans performed well in this population.
The higher the Native American ancestry the lower the GRS values.
Nature of Nonlocality in Triangle Network based on Elegant Joint Measurement
Authors: Kundu Amit , Sarkar Debasis 
Published: November 2023

AbstractDefining nonlocality in a no‐input closed quantum network scenario is a new area of interest nowadays. Gisin, in [Entropy 21, 325 (2019)], proposed a possible condition for non‐tri‐locality of the trivial no‐input closed network scenario, triangle network, by introducing a new kind of joint measurement bases and a probability bound. In [npj Quantum Information (2020) 6:70] they found a shred of numerical evidence in support of Gisin's probability bound. Now based on that probability bound, it finds the nature of the correlation in a triangle network scenario. This study observes how far the probability lies from that Gisin's bound with every possible combination of entangled and local pure states distributed from three independent quantum sources. Here, it uses the generalized Elegant Joint Measurements bases for each party and find that there is a dependency of non‐locality on the entanglement of these joint measurement bases. It also checks the probability bound for the polygon structure.
Connecting Biological and Synthetic Approaches for Electrocatalytic CO2 Reduction
Authors: Cobb Samuel J. , Rodríguez‐Jiménez Santiago , Reisner Erwin 
Published: November 2023

AbstractElectrocatalytic CO2 reduction has developed into a broad field, spanning fundamental studies of enzymatic ‘model’ catalysts to synthetic molecular catalysts and heterogeneous gas diffusion electrodes producing commercially relevant quantities of product. This diversification has resulted in apparent differences and a disconnect between seemingly related approaches when using different types of catalysts. Enzymes possess discrete and well understood active sites that can perform reactions with high selectivity and activities at their thermodynamic limit. Synthetic small molecule catalysts can be designed with desired active site composition but do not yet display enzyme‐like performance. These properties of the biological and small molecule catalysts contrast with heterogeneous materials, which can contain multiple, often poorly understood active sites with distinct reactivity and therefore introducing significant complexity in understanding their activities. As these systems are being better understood and the continuously improving performance of their heterogeneous active sites closes the gap with enzymatic activity, this performance difference between heterogeneous and enzymatic systems begins to close. This convergence removes the barriers between using different types of catalysts and future challenges can be addressed without multiple efforts as a unified picture for the biological‐synthetic catalyst spectrum emerges.