bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Development of an Interactive Mobile-based Job Portal for Blue-collar and Migrant Workers in Thailand: A Design Thinking Approach
Authors: Pyae Aung , Saetoen Suparuek , Vanichayangkuranont Supatach 
Published: October 2023

Abstract

This report details the creation and usability of a web-based job portal designed exclusively for blue-collar and migrant workers in Thailand, potentially serving as a model for global application. Amidst an existing void of efficient job-seeking platforms in Thailand, these workers face hardships in securing suitable employment, often leading to mistreatment. Employing design thinking methodology, we discerned user needs, crafting a solution emphasizing user-friendliness and usability for those with limited technical proficiency. The platform presents clear job information, facilitating efficient searches. Comprising two interconnected web applications—one for job seekers and another for recruiters—this system underwent iterative design enhancements, receiving positive feedback from usability testing. Highlighting the essentiality of a user-centric design, this report underscores the platform’s potential to significantly improve employment prospects for these workers in Thailand. Moreover, the findings offer invaluable insights for similar global initiatives, aiming to mitigate employment challenges faced by blue-collar and migrant workers across various geographical and socio-economic contexts. The system’s model promotes the replication or adaptation of such user-centric job portals worldwide, aspiring to contribute towards more inclusive and equitable global labour market ecosystems. Through global adaptability, this project exemplifies a replicable blueprint in advancing job accessibility for blue-collar and migrant workers worldwide, thus advocating for broader systemic changes in the global labour market dynamics.
A Call for Increased Inclusivity and Global Representation in Pharmacogenetic Testing
Authors: Cohn Iris , Kennedy April , Ma Gabriel , Manshaei Roozbeh , Jobling Rebekah , Kim Raymond , Lewis Tamorah 
Published: October 2023

Abstract
Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared variation in five pharmacogenes detected by whole genome sequencing (WGS) to a targeted commercial panel in a cohort of 308 individuals with family history of pediatric heart disease. In 1% of the cohort, WGS identified rare variants that altered the interpretation of metabolizer status and would thus prevent potential errors in gene-based dosing.
A Comparison Between SAR Tomography and the Phase Histogram Technique for Remote Sensing of Forested Areas
Authors: Wu Chuanjun , Tebaldini Stefano , Yu Yanghai , Manzoni Marco , Liao Mingsheng 
Published: October 2023

Abstract
This paper compares two approaches for estimating forest height and vertical structure using synthetic aperture radar (SAR) data, namely the well-known SAR tomography (TomoSAR) technique and the recently introduced phase histogram (PH) technique. By jointly exploiting multiple SAR images, TomoSAR allows for direct imaging of the three-dimensional structure of the vegetation, from which biophysical parameters such as forest height and terrain topography can be extracted. The PH technique assigns each pixel in a SAR interferogram to a specific height bin based on the value of the corresponding interferometric phase, thus allowing for the estimation of the forest vertical structure by accumulating pixels magnitudes within a given spatial window. The two techniques are here compared on an experimental basis using L-Band tomographic data from the ESA campaign TomoSense, flown in 2020 at the Eifel Park in North West Germany. The analysis we present considers a characterization of forest scattering by 3D imaging and forest height retrieval. Experimental results indicate that the PH technique can only loosely approximate the vertical structure produced by SAR tomography. Still, it can produce a reasonably good estimate of forest height. In particular, TomoSAR and the PH technique are observed to have an average root mean square error (RMSE) with respect to Lidar estimate of 2.63 m and 4.35 m in North-West heading data, and 1.84 m and 5.46 m in South-East heading data, respectively. The observed results are interpreted in light of a simple physical model to characterize phase histograms depending on the number of scatterers within the SAR resolution cell, on which basis we derive analytical expressions to predict height dispersion in phase histograms. The conclusion from both experimental and theoretical results is that phase histograms cannot correctly reproduce forest structure, unless the distribution of scatterers within the SAR resolution cell is characterized by a single dominant scatterer. Consistently, we conclude that the PH technique is inherently best suited for the analysis of high- or very-high resolution data, which suggests its use in the context of higher frequency SAR Missions.
Свободно циркулирующая ДНК в плазме у пациентов с диффузной В-крупноклеточной лимфомой и В-клеточной лимфомой высокой степени злокачественности (‘double hit’/’triple hit’)
Authors: Смирнова Светлана Юрьевна , Никулина Е. Е. , Габеева Н. Г. , Королева Д. А. , Татарникова С. А. , Смольянинова А. К. , Гемджян Э. Г. , Звонков Е. Е. , Судариков А. Б. 
Published: October 2023

Aim. To study plasma cell-free DNA (pcfDNA) concentration and B-cell clonality in patients with diffuse large B-cell (DLBCL) and B-cell high-grade lymphomas prior to and at different stages of chemotherapy as well as the correlation between the data obtained and clinical and laboratory parameters.
Materials & Methods. The study enrolled 23 DLBCL patients and 7 healthy donors (HD). Plasma was prepared from whole blood by centrifugation, pcfDNA was isolated with the commercial kit Qiagen (Germany). The concentration of pcfDNA was determined using fluorometer Qubit (USA). В-cell clonality was estimated by immunoglobulin gene analysis (BIOMED-2 protocol) in the tumor tissue and bone marrow core biopsy specimens obtained on diagnosis date as well as in the pcfDNA at 5 end points: prior to chemotherapy and after cycles 1, 2, 3, and 4.
Results. Prior to therapy, all DLBCL patients showed significantly higher pcfDNA concentration than HD. Immunochemotherapy cycle 1 resulted in considerable increase in pcfDNA concentration. After cycle 2 and subsequent cycles, pcfDNA concentration gradually decreased. After cycle 4, the mean pcfDNA concentration was comparable with that of HD. In 95 % of patients В-cell clonality in pcfDNA corresponded to that identified in the tumor specimen. After immunochemotherapy cycle 1, В-cell clonality was detected in 50 % of patients, after cycle 2 it was shown by 15 %. Only 1 female patient retained В-cell clonality after therapy cycles 3 and 4. In HD, no В-cell clonality in pcfDNA was identified. Prior to therapy, the analysis revealed no correlation of either pcfDNA concentration or В-cell clonality in pcfDNA with age, sex, tumor spread, presence or absence of extranodal lesions, proliferation index Ki-67, and lactate dehydrogenase concentration.
Conclusion. In patients with malignant hematological tumors, pcfDNA seems to be an interesting, easily accessible biological material deserving further investigation. Any studies of pcfDNA require long-term dynamical analysis and standardized methods of collection, storage and processing of the data obtained. In the long run, with more and more information, pcfDNA can become an important diagnostic marker of tumor heterogeneity and a reliable relapse predictor.
Fluorescent Coumarin-based Probe for Detection of Biological Thiols
Authors: Szwaczko Katarzyna 
Published: October 2023

Abstract:
Nature-derived thiols such as cysteine, homocysteine, and reduced glutathione play
diverse and important roles in both plant and animal cells. In plants, they maintain redox homeostasis
and affect photosynthesis and signal transduction processes. In animals, changes in the levels
of biothiols have been linked to cardiovascular disease, Alzheimer's disease, neuropsychiatric
disorders, or stroke. The detection of biothiols in biological samples is, therefore, very important.
For this purpose, rapid, sensitive, and non-invasive methods for their sensing in living cells are
highly desirable.

:
This perspective reviews the past five years of advances in coumarin fluorescent probes for biothiol
detection. The design of the probes, the mechanisms of thiol detection, and the applications in live cell
imaging are presented. The classification of probes based on the coumarin backbone was made on the basis of
the mode of their interactions with the analyte.
Copper Oxide Supported on Silica (CuO/SiO2): A Highly Efficient Heterogeneous
Catalyst for the Synthesis of 1,2-Dihydroquinazolines at Room Temperature
Authors: Suri Mrinaly , Saikia Ujwal Pratim , Saikia Trishna , Namdeo Ashutosh , Pahari Pallab 
Published: October 2023

Abstract:
A copper oxide supported on silica (CuO/SiO2) catalyst has been prepared which
catalyzes a three-component reaction between 2-aminobenzopenone, benzaldehyde, and ammonium
hydroxide leading to a convenient synthesis of 1,2-dihydroquinazoline. The main advantages
of the process over the previous reports are room temperature reaction, selective
formation of 1,2-dihydroquinazoline as a sole product, and recyclability of the catalyst. Seventeen
derivatives with various substituents are prepared. The catalyst (fresh and recovered) has
been fully characterized using HR-TEM, BET Surface area, XPS, FTIR, and XRD. The enhanced
activity and selectivity of the catalyst (towards 1,2-dihydroquinazoline) is attributed to
the formation of Cu-O-Si type surface structure which is also explained by the help of different
analytical techniques. Further, the reaction was performed without a catalyst, with CuO and SiO2 separately.
Based on catalyst characterization and experimental results a possible mechanism has been proposed
and discussed thoroughly. Recovery and reusability of the catalyst have also been studied.
A New Flavonoid Derivative and Inhibitory Effects on Xanthine Oxidase and
α-glucosidase from
Glinus oppositifolius
Authors: Hien Nguyen Thi Thu , Dung Huynh Tran Quoc , Minh Bui Hoang , Chen Tran Van , Tuan Nguyen Trong , Dung Le Tien 
Published: October 2023

Abstract:
In previous studies on bioactivities, some extracts from Glinus oppositifolius possessed
antimicrobial, antifungal, antiplasmodial, anti-inflammatory, anti-diarrhoeic, antihyperlipidemic,
and hepatoprotective. However, information on the xanthine oxidase inhibitors’
properties of G. oppositifolius is still limited. For the purpose of discovering new leads with potential
α-glucosidase inhibition, the less explored plant G. oppositifolius has been investigated. A
new apigenin flavone glucoside, named apigenin-5-O-β-D-glucopyranosyl-8-C-β-Dglucopyranoside
(7), together with seven known compounds (spergulacin (1), glinoside C (2),
spergulacin A (3), spergulin B (4), spergulin A (5), vitexin (6), vicenin 2 (8)) were identified
from Glinus oppositifolius (L.) Aug. DC. aerial parts. The identification of their structures involved
a comprehensive analysis utilizing extensive 1D and 2D NMR techniques, mass spectrometry, and in
comparison with those from references. Compound 7 (IC50 =257.90 ± 1.00 μM) showed better inhibition of α-
glucosidase than acarbose (IC50 = 1021.47 ± 10.79 μM). Compound 8 (IC50 = 56.82 ± 1.95 μM) indicated a
good XO inhibitory effect.
Investigation of Antioxidant and Anti-inflammatory Properties of Berberine
Nanomicelles: In vitro and In vivo Studies
Authors: Heidarzadeh Marjan , Amininasab Mehriar , Rezayat Seyed Mahdi , Mousavi Seyyedeh Elaheh 
Published: October 2023

Introduction:
In the present study, neuroprotective effects of berberine (BBR) and berberine
nanomicelle (BBR-NM) against lipopolysaccharides (LPS)-induced stress oxidative were investigated,
and compared by evaluating their antioxidant and anti-inflammatory activities in PC12 cells,
and rat brains. A fast, green, and simple synthesis method was used to prepare BBR-NMs.

Method:
The prepared BBR-NMs were then characterized using dynamic light scattering (DLS),
transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In vitro experiments
were carried out on the LPS-treated PC12 cell lines to investigate the anti-cytotoxic and antioxidant
properties of BBR-NM and BBR. The results showed that BBR-NMs with a diameter of
~100 nm had higher protective effects against ROS production and cytotoxicity induced by LPS in
PC12 cells in comparison with free BBR.

Results:
Moreover, in vivo experiments indicated that the activity levels of antioxidant enzymes, such as
superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), increased in the brain
of LPS-treated rats administrated with BBR-NM at the optimum dose of 100 mg.kg-1. BBR-NM administration
also resulted in decreased concentration of lipid peroxidation (MDA) and pro-inflammatory
cytokines, such as Serum interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α).

Conclusion:
Overall, BBR-NM demonstrated higher neuroprotective effects than free BBR, making
it a promising treatment for improving many diseases caused by oxidative stress and inflammation.
Phosphodiesterase Inhibitors of Natural Origin
Authors: Han Rui , Gaurav Anand , Mai Chun-Wai , Gautam Vertika , Gabriel Akyirem Akowuah 
Published: October 2023

Abstract:
Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular
signal transduction and physiological activities. PDEs can be divided into 11 families
(PDE1~11) and the diversity and complex expression of PDE family genes suggest that different
subtypes may have different mechanisms. PDEs are involved in various disease pathologies such
as inflammation, asthma, depression, and erectile dysfunction and are thus targets of interest for
several drug discovery campaigns. Natural products have always been an important source of bioactive
compounds for drug discovery, over the years several natural compounds have shown potential
as inhibitors of PDEs. In this article, phosphodiesterase inhibitors of natural origin have been
reviewed with emphasis on their chemistry and biological activities.
Effects of Cannabidiol in Adolescent and Young Adult Depressive
and Anxiety Disorders: A Systematic Review of Clinical and
Preclinical Research
Authors: Denson Rebecca K. , Brooks Julia , Pinna Graziano , Crane Natania A. 
Published: October 2023

Background:
Adolescents and young adults may use cannabidiol (CBD)
products in an attempt to reduce depression and anxiety symptoms, despite little
research examining this use. This systematic review evaluated preclinical and clinical
research on the effects of CBD on depressive and anxiety disorders in adolescence and
young adulthood. To provide context, we discuss CBD’s mechanism of action and
neurodevelopmental effects.

Methods:
PubMed was searched for articles published through June 2022. Preclinical
or clinical CBD administration studies with N > 1 that examined depressive and/or
anxiety disorders were eligible.

Results:
Initially, 224 publications were identified. After excluding duplicates and
applying eligibility criteria, 6 preclinical (depression: n≈133; anxiety: n≈161) and 4
clinical (anxiety: n=113) articles remained. Due to the low number of studies, results
were synthesized qualitatively. The Oxford Centre for Evidence-Based Medicine 2011
Levels of Evidence were used to rate each study’s evidence. The preclinical effects of
CBD on depression-like behavior appear to differ by sex, early life stress, and duration
of use. Despite no evidence that CBD exerts anxiolytic effects in preclinical adolescent
models, CBD may reduce anxiety symptoms in human adolescents and young adults
with anxiety disorders.

Conclusion:
The existing evidence suggests that CBD may reduce symptoms of anxiety
in adolescents and young adults. However, the evidence is sparse and limited by
variations in samples and CBD dosing duration. Further research is needed to understand
the potential benefits and/or harms of CBD for depression and anxiety disorders in this
population. Implications for clinical practice and research are discussed.
Wearable Devices to Diagnose and Monitor the Progression of COVID-19 Through Heart Rate Variability Measurement: Systematic Review and Meta-Analysis
Authors: Sanches Carlos Alberto , Silva Graziella Alves , Librantz Andre Felipe Henriques , Sampaio Luciana Maria Malosa , Belan Peterson Adriano 
Published: October 2023

Background
Recent studies have linked low heart rate variability (HRV) with COVID-19, indicating that this parameter can be a marker of the onset of the disease and its severity and a predictor of mortality in infected people. Given the large number of wearable devices that capture physiological signals of the human body easily and noninvasively, several studies have used this equipment to measure the HRV of individuals and related these measures to COVID-19.

Objective
The objective of this study was to assess the utility of HRV measurements obtained from wearable devices as predictive indicators of COVID-19, as well as the onset and worsening of symptoms in affected individuals.

Methods
A systematic review was conducted searching the following databases up to the end of January 2023: Embase, PubMed, Web of Science, Scopus, and IEEE Xplore. Studies had to include (1) measures of HRV in patients with COVID-19 and (2) measurements involving the use of wearable devices. We also conducted a meta-analysis of these measures to reduce possible biases and increase the statistical power of the primary research.

Results
The main finding was the association between low HRV and the onset and worsening of COVID-19 symptoms. In some cases, it was possible to predict the onset of COVID-19 before a positive clinical test. The meta-analysis of studies reported that a reduction in HRV parameters is associated with COVID-19. Individuals with COVID-19 presented a reduction in the SD of the normal-to-normal interbeat intervals and root mean square of the successive differences compared with healthy individuals. The decrease in the SD of the normal-to-normal interbeat intervals was 3.25 ms (95% CI −5.34 to −1.16 ms), and the decrease in the root mean square of the successive differences was 1.24 ms (95% CI −3.71 to 1.23 ms).

Conclusions
Wearable devices that measure changes in HRV, such as smartwatches, rings, and bracelets, provide information that allows for the identification of COVID-19 during the presymptomatic period as well as its worsening through an indirect and noninvasive self-diagnosis.
A STUDY ON GLASS CEILING PRINTING IN WORKING WOMEN
Authors: BUYRUKOĞLU Erhan , ÖZDEMİR Mehmet , DOKUZOĞLU Gökhan , ASANAKUT Nuh 
Published: October 2023

Our research was carried out with the aim of examining the glass ceiling pressure levels of women working in
sports area public and private institutions in Aydın in terms of some variables. The study group of the research
consists of female participants working in different sectors in Aydın. Data collection in the study consists of two
parts. Personal information form created by the researchers in the first part, Career Pathway Surwey-CPS
developed by Smith et al. (2012) and adapted in Turkish by Sarıoğlu (2018) were used in the second part. In the
analysis of the data in this study, the SPSS 25.00 package program was used, and it was evaluated at the 95%
confidence interval and at the 0.05 significance level. Descriptive statistics were calculated regarding age,
marital status, educational status, having a child, position in the institution, professional experience and
institution, personal information. It was decided whether the data showed a normal distribution or not by
looking at the kurtosis skewness values. In terms of statistics, Independent Sample t test, Anova test,
frequency, percentage and reliability coefficient calculations were made. As a result; With the glass ceiling
syndromes that female working participants are exposed to; According to the Anova test performed between
the age variable, only in the acceptance sub-dimension, in the t-test performed between the marital status
variable in the dimensions of endurance and acceptance, in the acceptance dimension according to the t-test
performed between the marital status variable, in the acceptance sub-dimension only in the t-test performed
between the educational status variable. It is seen that there is a significant difference (p&lt;0.05).
Strategi Pemasaran Melalui Media Sosial Instagram Saat Pandemi Covid-19
Authors: Astrawan I Made Doni , Wirawan Putu Eka 
Published: October 2023

The Aveda Boutique Hotel ialah hotel internasional bintang 4 yang terserang akibat pandemi COVID- 19. Di masa digital ini bisa dijadikan selaku fasilitas promosi yang efisien buat tingkatkan penjualan kamar. Oleh sebab itu, tujuan dari riset ini merupakan buat mengenali gimana strategi promosi media sosial Instagram yang diterapkan The Aveda Boutique Hotel sepanjang masa pandemi covid- 19. Tata cara pengumpulan informasi yang digunakan merupakan observasi, riset dokumen serta wawancara. Tata cara analisis informasi yang digunakan merupakan tata cara deskriptif kualitatif. Hasil riset yang digunakan merupakan hasil wawancara dengan penulis di posisi riset serta pemakaian analisis SWOT. Akhirnya merupakan sebab strategi promosi yang digunakan cocok dengan yang diharapkan, penjualan kamar di The Aveda Boutique Hotel cenderung flat sepanjang masa pandemi serta bertahan sampai dikala ini.

The Aveda Boutique Hotel is a 4-star international hotel currently being hit by the COVID-19 pandemic. In this digital era, it can be used as an efficient promotional tool to increase room sales. Therefore, the purpose of this study was to identify the Instagram social media promotion strategy implemented by The Aveda Boutique Hotel during the COVID-19 pandemic. Information collection procedures used were observation, document research and interviews. The information analysis procedure used is a qualitative descriptive procedure. The results of the research used are the results of interviews with the author in the research position and the use of SWOT analysis. Finally, because the promotional strategy used has met expectations, room sales at The Aveda Boutique Hotel tend to be flat throughout the pandemic and have lasted until now.
On Sum and Geometric Sum of independent New Quasi Lindley Random Variables and its Applications
Authors: Alosey Alaa Rafat El 
Published: October 2023

The Laplace transformation method is used to drive the distribution of the sum Sn of n-fixed random variables, which has a new quasi Lindley distribution with two parameters θ and α, NQLD (θ,α). The sum of NQLD (SUNQLD) distribution is obtained in pdf and cdf formats. It is discussed how to calculate the random sum SN of a random number of NQLD random variables. The random sum of the NQLD distribution's pdf and cdf are calculated. When N has a geometric distribution, the geometric sum of NQLD distribution (GSN QLD) was introduced as an example of a random number of NQLD random variables. For all cases, some statistical measures are determined. The distribution's parameters are estimated using the maximum likelihood method. To test the viability and efficiency of the proposed distributions SNQLD and GSNQLD, lifetime count data sets from acute myeloid leukaemia are fitted. The results should become accepted knowledge in the fields of probability theory and its allied sciences. In addition, the histogram, fitted probability density function (pdf), and P-P plots for the analyzed real data set are presented.