bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galiridosid, ein Iridoidglucosid aus Galeopsis tetrahit L. (Labiatae)
Authors: Sticher O. 
Published: December 2004

AbstractFrom fresh leaves of Galeopsis tetrahit L. (Labiatae) a compound observed earlier only by paper chromatography and known as ‘Tetrahit‐Pseudoindican’ or ‘Gal. tetr. 47’ has been isolated, and its constitution (II) as a new iridoid glucoside has been established. The name of galiridoside is proposed for this compound.Acetylation of galiridoside gave the tetraacetyl‐derivative III. Catalytic reduction of II by Pd/C gave dihydrogaliridoside (IV). Basic hydrolysis of II with Ba(OH)2 gave desepoxydihydroxy‐galiridoside (VI). Reduction of galiridoside by lithium and ammonia yielded among other compounds a small amount of dideoxy‐aucubin (XI), isolated as its tetraacetate XII.The NMR. spectra of galiridoside and its derivatives support the proposed structure and configuration.
Die Struktur des Antibioticums Roridin E. Verrucarine und Roridine, 21. Mitteilung [1]
Authors: Traxler P. , Zürcher W. , Tamm Ch. 
Published: December 2004

AbstractStructure 1 has been established for roridin E (C29H38O8), an antibiotic isolated from cultures of Myrothecium species. Base catalysed hydrolysis of 1 gave the known sesquiterpene alcohol verrucarol (4; C15H22O4) and 2′‐anhydrororidinic acid (6; C14H20O6), a new dicarboxylic acid. The structure of 6 was determined by spectral analysis of its dimethyl ester 7, dimethyl hexahydro‐2′‐anhydrororidinate (9), the acetyl derivative 10, and the oxidation product 11.
Trispara‐aspidin, ein neues Phloroglucid aus dem Farn Dryopteris remota (A. Br.) Hayek
Authors: Widén C.‐J. , von Euw J. , Reichstein T. 
Published: December 2004

AbstractDryopteris remota (A. Br.) Hayek is regarded as a triploid apogamous species, perhaps a hybrid of ♀ D. assimilis Walker with ♂ diploid D. borreri Newm. The phloroglucides (phloroglucinol derivatives) of its rhizomes were investigated; their nature is compatible with the mentioned hypothesis. Besides several known compounds a new tricyclic phloroglucide C36H44O12, designated trispara‐aspidin was isolated. According to mass spectrum and products of reductive cleavage it has the structure given in formula 14.
Steroide und Sexualhormone. 239. Mitteilung [1]. Die Partialsynthese von Anhydroholantogenin
Authors: Schaffner B. P. , Berner‐Fenz Frau L. , Wehrli H. 
Published: December 2004

AbstractA synthesis of the title compound 4, which had been isolated [2] in form of an amino glycoside from the leaves of Holarrhena antidysenterica is described, using 2 [1] as starting material.
Säurekatalysierte Umlagerung von Allyl‐cyclohexadienon‐tosyl‐hydrazonen: Beispiel einer Dienimin‐Anilin‐Umlagerung
Authors: Schmid [1] M. , Hansen H.‐J. , Schmid H. 
Published: December 2004

AbstractThe tosylhydrazones of 4‐allyl‐ and 4‐crotyl‐4‐methyl‐cyclohexa‐2, 5‐dien‐l‐one (14 and 15) rearrange in the presence of acid to yield the corresponding 2‐allyl‐ and 2‐α‐methylallyl‐hydrazines 17 and 18, respectively. A similar behaviour is shown by the tosylhydrazone of 2‐allyl‐2‐methyl‐cyclohexa‐3, 5‐dien‐1‐one (16). 16 could not be isolated. The observed acidcatalysed [3 s, 3 s]‐sigmatropic rearrangement of the tosylhydrazones can be regarded as a rearrangement of the dienimine‐aniline type.
Synthese eines neuen Derivats der Insulinsequenz B1–8 mit verbesserter Löslichkeit
Authors: Bosshard H. R. 
Published: December 2004

AbstractThe synthesis of the protected octapeptide N‐t‐butoxycarbonyl‐phenylalanyl‐valylasparaginyl‐glutaminyl‐Nim‐tritylhistidyl‐leucyl‐S‐benzhydrylcysteinyl‐glycine‐hydrazide L
, corresponding to the amino‐terminal sequence of the insulin B‐chain, is described. Up to the protected octapeptide all intermediates have greatly improved solubility properties in neutral organic solvents in comparison with other synthetic derivatives of the same sequence.
Anlagerung von Enoläthern, Acetylenäthern und Heterocyclen an 2‐Acetyl‐1,4‐benzochinon
Authors: Kuser P. , Frauenfelder E. F. , Eugster C. H. 
Published: December 2004

Abstract2‐Acetyl‐1,4‐benzochinon, das ein stärkeres Elektrophil als Benzochinon ist, setzt sich unter sehr milden Bedingungen mit Enoläthern zu 2‐Alkoxy‐4‐acetyl‐5‐hydroxy‐2,3‐dihydrobenzofuranen, mit Acetylenäthern zu den entsprechenden Benzofuranen, mit 3,4‐Dihydrofuran zu hydrierten Furo[2, 3‐b]‐furanen und mit 5, 6‐Dihydropyran zu hydrierten Pyrano[2, 3‐b]‐furanen um. Unter gewissen Bedingungen führt die Kondensation zwischen Acetylbenzochinon und Furan oder Silvan zum hydrierten Furo[3, 2‐b]furan‐System. Imidazol und 2, 5‐Dimethylprazol addieren mit dem N; Pyrrole werden in α‐oder β‐Stellung mono‐ oder disubstituiert zu violetten oder blauen Pyrrolchinonen. Arbeiten früherer Autoren über Addition von Pyrrolen an Benzochinon werden diskutiert.
Die konjugative Wechselwirkung zwischen π‐ und Walsh‐Orbitalen: Das Photoelektron‐Spektrum des Homofulvens
Authors: Gleiter R. , Heilbronner E. , de Meijere A. 
Published: December 2004

AbstractAnalysis of the photoelectron spectrum of homofulvene (1) (spiro [2.4] hepta‐4,6‐diene) confirms the conclusions previously drawn concerning the direct conjugation between π‐and Walsh‐orbitals. It is shown that the resonance integral (4) appropriate for the semi‐quantitative interaction of these orbitals amounts to −1.9 eV, i.e. nearly the value for conjugating π‐orbitals (β = −2.4 to −2.5 eV). This explains the close analogy between the photoelectron spectrum of 1 and that of fulvene.
C‐Glycosides VI. Modalités de l'élaboration de cycles pyrazoliques à partir d'une hydrazone d'aldéhydo‐sucre
Authors: Tronchet J. M. J. , Jotterand A. 
Published: December 2004

AbstractThe reaction of an aldehydo‐sugar hydrazonoyl bromide with ethynylmagnesium bromide led mainly to an α‐ethynyl‐hydrazone whose cyclisation to a pyrazole is catalysed by bases. Thus the nucleophilic substitution – nucleophilic cyclisation mechanism of the Grünangerpyrazole synthesis is confirmed. 3‐Glycosyl‐pyrazoles can also be prepared from aldehydo‐sugar hydrazonoyl bromides by 1,3‐dipolar cyclo‐addition. All these reactions take place without change in the configuration of the initial aldehydo‐sugar.
A Semi‐Empirical Model of the Energy Barrier of Proton Transfer Reactions
Authors: Willi Alfred V. 
Published: December 2004

AbstractThe energy barrier in proton transfer reactions is described by a Johnston‐type equation (1) (n = order of bond to be broken). The barrier model is discussed in terms of free energies. The Vi values are free energies of ionic cleavage in aqueous solution of the XH and YH bonds; they are computed from eqns. (4c) and (4d). The values of p1 and p2 affect curvature (absence or presence of maximum) and symmetry of the barrier. It is postulated that pi is a typical constant of the reacting bond and can be transferred from one transition state to another.With the aid of eqn. (1) and its first derivative, values of pi and nm (bond order at maximum of barrier) can be based on quantities determined experimentally, Δ≠ and ΔG. For OH bonds, pi ≈ 1.0. For CH bonds pi is larger than 1.0 and depends on the structure of the carbanionic moiety (influence of resonance and inductive effects).As there cannot be a maximum if p1 = p2 = 1.0, the suggested model of the barrier leads to a better understanding why proton transfer must be ‘fast’ in some reactions and ‘slow’ in others. The computed values of nm may be utilized to gain some insight into the nature of the transition states; they supply a basis for the discussion of primary hydrogen isotope effects.
Réactions de substitution dans l'anion tétrachloropalladate(II) avec des diamines. I. Ethylènediamine
Authors: Roulet R. , Ernst R. 
Published: December 2004

AbstractThe replacement of Cl− by ethylenediamine (en) in PdCl has been followed spectrophotometrically at 25°C and μ = 1 (NaClO4); it proceeds in two steps leading to Pd(en)Cl2 and Pd(en), respectively. The observed rate constants are discussed in terms of the mechanism proposed by Reinhardt [1] for the successive ammination reactions of PdCl.
Etude de composés d'addition d'acides de Lewis. XXXVI [1] Composés d'addition de l'anthraquinone‐9, 10 et de l'anthrone avec divers acides de Lewis
Authors: Giallonardo R. , Susz Bernard‐P. 
Published: December 2004

AbstractSolid stoichiometric adducts of 9, 10‐anthraquinone with SbCl5, ZrCl4, TiCl4 SnCl4, AlCl3, have been prepared. The very important lowering Δω of the IR. carbonyl frequency, ranging from −175 cm−1 for SbCl5 to −117 cm−1 for SnCl4, shows that the acceptor is linked by a dative bond to the carbonyl oxygen atom acting as a donor; an assignment of most of the fundamental IR. frequencies is proposed for anthraquinone and the mentioned adducts.Similar assignments and interpretation have been made for anthrone and its solid adduct with SbCl5, ZrCl4, TiCl4, SnCl4, AlCl3 and ZnCl2, where the CO lowerings range from −164 cm−1 for SbCl5 to −97 cm−1 for ZnCl2.
Die Aminoalkylierung von Chinoxalinen und Chinoxalonen 6. Mitteilung über grignard‐reaktionen mit halogenalkylaminen [1]
Authors: Marxer A. , Salzmann U. , Hofer F. 
Published: December 2004

AbstractQuinoxaline and 2(1H)‐quinoxalones react with organomagnesium salts differently from the corresponding phthalazines and quinazolines. 3‐Dimethylaminopropyl‐magnesiumchloride alkylates quinoxaline easily by addition to the 2 and 3 position forming a tetrahydroquinoxaline 2, which can be dehydrogenated to the corresponding dialkylated quinoxaline 3. The monosubstituted dihydroquinoxaline 5 is obtained only with difficulty. It can equally be dehydrogenated, yielding 6.Quinoxalones react with CH3MgI, C6H5MgBr, (CH3)2N(CH2)3MgCl by addition to the 3,4‐CN bond (not at the CO‐group), yielding 11–13. These dihydroquinoxalones are dehydrogenated to the 3‐substituted 2(1H)‐quinoxalones 14–16. Only 3‐phenyl‐quinoxalone adds a Grignard reagent at the CO group, forming a 2‐substituted 3‐phenylquinoxaline (26). 3‐Methyl‐quinoxalone exhibits an abnormal behaviour: It is deprotonated by the mentioned reagents at the CH3 group, and the 3‐methylenequinoxalone‐anion so formed attacks another molecule of methylquinoxalone, finally yielding 32 and 33.
L'action de l'ammoniac sur l'hydroxyde de cadmium et la stabilité des complexes en milieu aqueux
Authors: Gübeli A. O. , Taillon R. 
Published: December 2004

AbstractThe solubility of precipitated Cd(OH)2 was determined at 25°C in 1 M NaClO4, as a function of pH and of the ammonia content of the solutions. Formation constants were obtained for the following hydroxo, ammine and hydroxo‐ammine complexes: CdOH+, Cd(OH)2, Cd(OH), CdNH, Cd(NH3), Cd(NH3), Cd(NH3) and Cd(OH)2NH3. The solubility product of the hydroxide was also calculated.The presence of polynuclear species was investigated by titrimetric determinations of the hydrogen ion concentration at constant metal concentration.
Lävulinsäureanilid und 5‐Hydroxy‐5‐methyl‐1‐phenyl‐2‐pyrrolidon
Authors: Keller O. , Prelog V. 
Published: December 2004

AbstractThe hitherto unknown tautomer of levulinic acid anilide (Ia), 5‐hydroxy‐5‐methyl‐1‐phenyl‐2‐pyrrolidone (IIa), has been obtained by filtration of a chloroform solution of I a through acid ion‐exchange columns. Ia and IIa show typical differences in NMR., IR. and MS. that can be used for their detection and determination in mixtures. Both tautomers are stable at room temperature in solid state and in neutral solutions but are equilibrated in acidic and basic solutions.
Valenzisomerisierung von cis‐Dienonen, III Lichtinduzierte Umlagerung von 5‐Phenyl‐penta‐2,4‐dienaldehyden [1]
Authors: Schiess P. , Suter ChR. 
Published: December 2004

AbstractIrradiation of 5‐phenyl‐2,4‐pentadienaldehydes 1 and 2 leads to a rapid cis, trans‐isomerization of the 4,5‐double bond followed by formation of unsaturated ketenes 7 and 12, respectively, through a [1.5]‐hydrogen shift. In the dark, ketenes 7 and 12 revert at room temperature to the 5‐phenyl‐2,4‐pentadienaldehydes 1 und 2. Activation parameters and solvent dependence have been determined for this remarkably facile [1.5]‐sigmatropic rearrangement. The ketenes 7 and 12 are stable below − 20° in inert solvents. With alcohols and amines mixtures of α,β‐ and β,γ‐unsaturated acid derivatives are formed. Upon extended irradiation of 7 and 12 in aprotic solvents olefins 9 and 13 are formed through decarbonylation.
Human Milk Lysozyme: Unpublished Data Concerning the Establishment of the Complete Primary Structure; comparison with lysozymes of various origins
Authors: Jollès Jacqueline , Jollès Pierre 
Published: December 2004

AbstractDetails concerning the establishment of the complete primary structure of human milk lysozyme (previously published in a preliminary note) are presented. The chymotryptic peptides obtained from the reduced alkylated enzyme were purified and their amino acid sequences determined chiefly by the ‘Edman‐dansylation’; procedure, and in two cases by partial acid or peptic hydrolyses. The tryptic peptides are alined into a single chain containing 129 amino acid residues, on the basis of overlapping peptides. Two labile glutamine residues easily converted into glutamic acid residues were characterized. Human milk lysozyme is compared with other human lysozymes (from normal and leuchaemic individuals) prepared by our group. The structure proposed is identical with the sequence of human leuchaemia lysozyme (from the urine of a patient with chronic monocytic leuchaemia) reported by Canfield. Human milk lysozyme is also near by related to several bird egg‐white lysozymes (and bovine α‐lactalbumin): Identical positions of Cys and Trp residues and of the residues essential for the catalytic activity or involved in some hydrogen bonds; several identical regions, especially in the β‐sheet region; between 71 and 77 identical amino acid residues. It is suggested that by an insertion and a deletion in the sequence of human milk lysozyme, sequences homologous to those of bird lysozymes can be obtained.
Zur säurekatalysierten Cyclisation von Verbindungen der Damascenon‐Reihe
Authors: Ohloff G. , Schulte‐Elte K. H. , Demole E. 
Published: December 2004

AbstractThe acid catalyzed cyclisation of α‐ and β‐diamascone (4 and 1) as well as β‐damascenone (2) has been examined under different conditions. The reaction mechanism is discussed.
Strukturaufklärung zweier Pigmentfarbstoffe der Perylen‐Reihe
Authors: Manukian B. K. , Mangini A. 
Published: December 2004

AbstractThe structures of C.I. Pigment Red 149 (PV Fast Red B)® and C.I. Pigment Red 178 (Paliogen Red GG)® as II and III respectively, are deduced from elemental analysis, spectroscopic data, and synthesis.
Reaktionen von Steroid‐Hypojoditen X. Fragmentierung von 20‐Hydroxy‐Steroiden (17‐Jod‐androstane). Über Steroide, 226. Mitteilung
Authors: Biollaz M. , Kalvoda J. 
Published: December 2004

AbstractIn the hypoiodite reaction of 20‐hydroxy steroids, 17α‐ and 17β‐iodo androstanes are formed as by‐products by fragmentation of the intermediate alkoxy radicals. The epimeric iodides show antipodal CD.‐ and ORD.‐ curves in accordance with their absolute configuration at the relevant chiral centre C(17).
Die Kristallstruktur des 3β‐Acetoxy‐17α‐jod‐Δ5‐androstens
Authors: Mez H.‐C. , Rihs G. 
Published: December 2004

AbstractThe crystal structure of 3β‐acetoxy‐17α‐iodo‐Δ5‐androstene (C21H31O2I) has been determined from three‐dimensional X‐ray data and refined to a final reliability index of R = 5.1% for the 2352 observed reflexions. Crystals grown from methylene chloride/methanol are orthorhombic, space group P212121, with cell constants a = 6.430, b = 10.563, c = 29.369 Å.
Eine neue Amidinsynthese mit Hilfe der Grignard‐Reaktion. 7. Mitteilung über Grignard‐Reaktionen [1]
Authors: Marxer A. 
Published: December 2004

AbstractIn an unusual manner benzonitrile 5 and the substituted benzonitriles 1, 14 reacted with benzylmagnesiumhalides to yield, besides dibenzyl, the amidines 7, 13, 15, substituted on the imide nitrogen by a 1,2‐diphenyl‐vinyl group. The proposed structures are based on NMR. and mass spectra.
Stoffwechselprodukte von Mikroorganismen. 104. Mitteilung [1]. Die Struktur des Cinerubins B.
Authors: Richle W. , Winkler E. K. , Hawley D. M. , Dobler M. , Keller‐Schierlein W. 
Published: December 2004

AbstractThe structural determination of the anthracycline antibiotic Cinerubine B by degradation, spectroscopic studies and an X‐ray crystallographic analysis of a degradation product is described.
The Crystal and Molecular Structures of an Unusual Estra‐Steroid and of its Dihydroproduct
Authors: Weber H. P. , Galantay E. 
Published: December 2004

AbstractThe crystal and molecular structures of 17‐ethylenedioxy‐3‐methoxy‐6,7,8‐methylidyne‐1,3,5(10)‐estratriene (1) and of 17β‐bromo‐acetoxy‐3‐methoxy‐8α‐methyl‐1,3,5(10),6‐estratetraene (3) have been determined by X‐ray analysis. A short discussion of the structures is given, and a new picture of the structure‐activity relation of estrogenics is proposed.
Utilisation d'ylides du phosphore en chimie des sucres, X. Synthèse stéréospécifique de l'épimère en C3 du streptose et d'autres sucres ramifiés, dérivés de désoxy‐5‐pentoses, à groupements gem‐hydroxy‐formyle ou gem‐hydroxy‐hydroxyméthyle
Authors: Tronchet J. M. J. , Graf R. , Gurny R. 
Published: December 2004

AbstractThe synthesis of branched‐chain sugars of the gem‐hydroxy‐formyl and the gem‐hydroxy‐hydroxymethyl types is described. A 5‐deoxy‐1,2‐O‐isopropylidene‐furanos‐3‐ulose is treated with cyanomethylene‐triphenyl‐phosphorane, yielding the two geometrical isomers of the corresponding branched‐chain unsaturated sugar. Cis‐dihydroxylation(KMnO4) of these cyanomethylenic compounds affords stereoselectively and in high yield the gem‐hydroxy‐formyl branched chain sugars whose formyl group is on the more hindered face of the furanose ring. The hydroxymethyl analogues of the latter compounds are readily prepared by their borohydride reduction. This method constitutes a new general route to type A branched‐chain sugars epimeric at the branching‐point with the sugars which would have been obtained by the classical procedure involving Grignard reagents.
Stereochemical Assignment of the Two Isomeric Tropine N‐Oxides by Proton Magnetic Resonance at 220 MHz
Authors: Bachmann K. , von Philipsborn W. 
Published: December 2004

AbstractProton magnetic resonance spectra of tropine and the two isomeric tropine N‐oxides have been analysed at 220 MHz. Chemical shifts in the N‐oxides are expressed relative to tropine (Δv) and permit unequivocal structural assignments of the predominant isomer (1, equatorial N‐oxide) and the minor isomer (2).
The Reaction of Phenyl(trichloromethyl)mercury with Substituted Norbornenes
Authors: Jefford C. W. , Hill D. T. , Goré J. , Waegell B. 
Published: December 2004

AbstractThe addition of phenyl(trichloromethyl)mercury to five substituted norbornenes is described, and the results compared with those obtained with bicyclo[2.2.2]oct‐2‐ene and 3,3,5,5‐tetramethylcyclopentene. The reaction proves to be useful for synthetic purposes, in that it leads usually to ring expansion. However, a possible disadvantage is that the addition step is sensitive to steric hindrance and depends on the reactivity of the double bond.
Anil‐Synthese. 6. Mitteilung. Über die basenkatalysierte Umsetzung von methylsubstituierten 2H‐Naphtho[1,2‐d]triazol‐2‐yl‐benzolen und ‐naphthalinen mit Anilen aromatischer Aldehyde
Authors: Brunold M. , Siegrist A. E. 
Published: December 2004

AbstractMethylgruppen in verschiedenen Stellungen des Benzolringes von 2H‐Naphtho[1,2‐d]triazol‐2‐yl‐benzol können mit Anilen aromatischer Aldehyde in Dimethylformamid in Gegenwart von Kaliumhydroxid in Styrylgruppen übergeführt werden («Anil‐Synthese»). Der Einfluss von Substituenten in Nachbarstellung zur Methylgruppe von 2‐(p‐Tolyl)‐2H‐naphtho[1, 2‐d]triazol auf den Reaktionsablauf wird untersucht. Aus 2‐Fluor‐4‐(2H‐naphtho[1, 2‐d]‐triazol‐2‐yl)‐toluol und Anilen aromatischer Aldehyde entstehen in Dimethylformamid in Gegenwart von Kaliumhydroxid 1,2,3‐Triphenyl‐7‐(2H‐naphtho[1, 2‐d]triazol‐2‐yl)‐1,4‐dihydrochinolin‐Derivate.
Synthese der 2,5‐Diole des A‐nor‐5α‐Androstan‐17β‐ols und A‐nor‐5β‐Androstan‐17β‐ols
Authors: Lábler L. , Tamm Ch. 
Published: December 2004

AbstractThe synthesis of A‐nor‐5β‐androstane‐2α,5,17β‐triol (8), A‐nor‐5β‐androstane‐2β,5,17β‐triol (10), A‐nor‐5α‐androstane‐2β,5,17β‐triol (20), A‐nor‐5α‐androstane‐2β,5,17β‐triol (22) and of their 17‐O‐benzoyl derivatives is described, using A‐nor‐testosterone (1) as starting material.
Orbital Theory of Heterolytic Fragmentation and Remote Effects on Nitrogen Inversion Equilibria
Authors: Gleiter Rolf , Stohrer Wolf‐Dieter , Hoffmann Roald 
Published: December 2004

AbstractFrom a molecular orbital study of model systems we derive the electronic requirements for the Grob fragmentation. The necessary condition for an allowed fragmentation in an X‐C1‐C2‐C3‐N system, or the amino cation +C1‐C2‐C3‐N is the level ordering A below S. This in turn is set by maximal through‐bond coupling of the empty cation orbital and the nitrogen lone pair. The conformational dependence of through‐bond coupling is exactly that derived by Grob, namely parallel orientation of the cation orbital (or the C‐X bond), the C2‐C3‐σ‐bond, and the N‐lone‐pair. When the C1‐C2‐C3 and C2‐C3‐N angles are small, the through‐space interaction dominates, reversing the level ordering to S below A, and consequently makes the fragmentation forbidden even though the conformational requirements for it are met. Ring closure becomes allowed. Some examples exploiting this result are presented, as well as procedures for enhancing through‐bond coupling and thus fragmentation. The through‐bond‐effect has also kinetic consequences, allowing the definition of a new type of remote neighbouring group participation operative through bonds and not by direct overlap. The position of equilibria in nitrogen inversion processes should also be influenced by remote substituents which are π‐acceptors or donors.
Addition von Phthalidnatrium an 2‐Carbäthoxy‐8‐methoxynaphthochinon; eine neue Synthese für Hydroxy‐naphtacenchinone
Authors: Trueb W. , Eugster C. H. 
Published: December 2004

AbstractA simple method to synthesize hydroxysubstituted naphthacenequinones is described. Phthalide anion adds to negatively substituted quinones, e.g. ethyl‐8‐methoxy‐naphthatquinone‐2‐carboxylate. Acid catalysed cyclisation of this adduct under simultaneous decarboxylation yields a substituted naphthacene quinone.
Isolierung, Struktur und Synthese des Metaboliten von Azapropazon‐dihydrat
Authors: Mixich G. 
Published: December 2004

AbstractThe renal excretion of AZAPROPAZONE‐DIHYDRATE (X) Handelsname: PROLIXAN®. Hersteller: Siegfried AG, Zofingen.
by humans was investigated. Following oral administration a new substance was detected in the urine besides X by TLC. Both compounds were separated by preparative layer chromatography and shown to be unchanged X and its hydroxylated metabolite VIII. The structure of VIII was established by chemical and spectroscopic methods (IR., NMR.) and confirmed by synthesis (Scheme 1).
Fluorénacènes et fluorénaphènes Synthèses dans la série des indéno‐fluorènes, XVI. Méthyl‐5‐, diméthyl‐5, 6‐ et diphényl‐5, 6‐dihydro‐11, 12‐indéno [2.1‐a] fluorène
Authors: Chardonnens Louis , Bitsch Serge 
Published: December 2004

AbstractStarting from 2‐methyl‐ and from 2,3‐dimethyl‐1,4‐diphenyl‐butadiene‐1, 3 respectively, the 5‐methyl‐ and the 5,6‐dimethyl‐11, 12‐dihydro‐indeno[2.1‐a]fluorene are synthesized in 4 steps. The 5, 6‐diphenyl‐11, 12‐dihydro‐indeno[2.1‐a]fluorene is obtained by reduction of the already known 11, 12‐dioxoderivative. Accesorily a new preparation of the unsubstituted hydrocarbon is described.
Steroide und Sexualhormone. 244. Mitteilung. Synthese der C‐20 epimeren 7,8‐Dihydrobatrachotoxinine
Authors: Graf W. , Gössinger Frl. E. , Imhof R. , Wehrli H. 
Published: December 2004

AbstractA novel synthesis leading to the C(20) epimeric 7,8‐dihydroderivatives 16 [1] and 34 of batrachotoxinin A (1) [5] is described.