bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a delirium care critical‐thinking scale for intensive care unit nurses: A mixed‐method study
Authors: Chang Yu‐Ling , Hsieh Ming‐Ju , Pan Ching‐I , Shang Shu‐Ting , Tsai Yun‐Fang 
Published: January 2024

AbstractAim and ObjectivesTo develop a Delirium Care Critical‐Thinking Scale for nurses caring for patients in the intensive care unit and examine the scale's psychometric properties.BackgroundThere is a tool to evaluate nurses' critical thinking skills to determine nursing competency when delirium care is required.DesignThis cross‐sectional, mixed‐methods study.MethodsThe Delphi method was applied for collection and analysis of data during conceptualization and item generation of the tool (Phase I). Item analysis, assessment of validity and reliability of the scale (Phase II) involved 318 nurses recruited by convenience sampling from nine adult intensive care units in medicine and surgery at one medical centre. Confirmatory factor analysis assessed construct validity. Internal consistency and 2‐week test–retest stability measured reliability. A Critical Thinking Disposition Inventory Scale examined concurrent validity.ResultsAfter three rounds, the Delphi method resulted in 31 scale items. Item analysis demonstrated construct reliability ranged from 9.23 to 16.18. Confirmatory factor analysis eliminated one item and extracted five factors: applying knowledge, confirming the problem and accuracy of information, reasoning logically, choosing appropriate strategies and remaining open‐minded. Average variance extracted values of all factors indicated good convergent validity. Cronbach's α for internal consistency was .96 with good test‐retest reliability. The correlation coefficient for concurrent validity was .301.ConclusionThe new Delirium Care Critical‐Thinking Scale for intensive care nurses was demonstrated to be a reliable and valid tool for evaluating their ability to assess patients with delirium.Relevance to Clinical PracticeThis new scale could be used to assess outcomes of education interventions and the effectiveness of nursing care quality involving patients with delirium in intensive and critical care units.Reporting MethodThe COSMIN checklist was used as the reporting guideline for this study.Patient or Public ContributionNone.
Using fusion effects to decrease uncertainty in distance sampling models when collating data from different surveys
Authors: Plard Floriane , Araújo Hélder , Astarloa Amaia , Louzao Maite , Saavedra Camilo , Bonales José Antonio Vazquez , Pierce Graham John , Authier Matthieu 
Published: January 2024

AbstractEstimates of population abundance are required to study the impacts of human activities on populations and assess their conservation status. Despite considerable effort to improve data collection, uncertainty around estimates of cetacean densities can remain large. A fundamental concept underlying distance sampling is the detection function. Here we focus on reducing the uncertainty in the estimation of detection function parameters in analyses combining data sets from multiple surveys, with known effects on the precision of density estimates. We developed detection functions using infinite mixture models that can be applied on data collating multiple species and/or surveys. These models enable automatic clustering by fusing the species and surveys with similar detection functions. We present a simulation analysis of a multisurvey data set in a Bayesian framework where we demonstrated that distance sampling models including fusion effects showed lower uncertainty than classical distance sampling models. We illustrated the benefits of this new model using data of line transect surveys from the Bay of Biscay and Iberian Coast. Future estimates of abundance using conventional distance sampling models on large multispecies surveys or on data sets combining multiple surveys could benefit from this new model to provide more precise density estimates.
Lead and generator dysfunction in children and adolescents with epicardial pacemaker and implantable cardioverter defibrillator systems: The challenge of early recognition
Authors: Winkler Florian , von Felten Stefanie , Gass Matthias , Berger Florian , Weber Roland , Dave Hitendu , Balmer Christian 
Published: January 2024

AbstractBackgroundA major issue of cardiac implantable electronic device therapy in pediatric patients is the high incidence of lead dysfunctions and associated reinterventions. This study aims to analyze the timing and mode of generator and lead dysfunction.MethodsRetrospective single‐center analysis of 283 children and young adults with an epicardial pacemaker or implantable cardioverter defibrillator therapy from 1998 to 2018.ResultsMean age at implant was 6.1 years (SD ± 5.8 years) and median follow‐up 6.4 years (IQR, 3.4–10.4 years) with a total of 1998.1 patient‐years of cardiac device therapy. A total of 120 lead‐related complications were observed in 82 patients (29.0%). They were detected by device interrogation (n = 86), symptoms (n = 13), intraoperative findings (n = 7), routine chest radiography (n = 5), routine ECG (n = 4), patient alert sound by device (n = 3), and physical examination (n = 2). It was possible to find the date of the event on the device memory in 21 out of 120 lead dysfunctions (18%) with a median time interval between occurrence and detection of 1.3 months (IQR, 0.2–5.0 months). Moreover, 20 generator‐related complications were found in 13 patients.ConclusionsEarly recognition of lead and generator dysfunction remains challenging in pediatric patients. As symptoms are relatively rare conditions in the context of PM and ICD dysfunction, close patient monitoring is mandatory, even in asymptomatic patients with a good clinical course. To further improve the safety of pediatric pacing systems, more durable epicardial electrodes are desirable.
Dorsal root ganglion stimulation (DRG‐s) for potential resolution of restless leg syndrome symptoms and increased cost savings for patients: A case study
Authors: Abd‐Elsayed Alaa , Moghim Robert , Reffat Noora 
Published: January 2024

AbstractIntroductionWe report successful use of dorsal root ganglion stimulation (DRG‐s) to treat a patient with persistent symptoms of restless leg syndrome (RLS).MethodsThe treatment involved the placement of a small device millimeters away from the patient’s DRG, which are nerves near the spinal cord that carry sensory information from the periphery of the body to the brain. The device automatically delivers electrical impulse to the DRG to alter and decrease pain perception in the brain.ResultsOur case report elucidates the use of this procedure as a targeted therapy for RLS, with a nearly 90% reduction in reported symptoms in our patient, thus potentially reducing morbidity associated with this condition. Furthermore, we report a 10‐year cost savings of nearly $90,000 following DRG‐s for our patient.ConclusionThis case study aims to demonstrate the effectiveness of DRG‐s neuromodulation in managing RLS, a condition that is often difficult and costly to treat.
Bio‐positive effects of ionizing radiation on pollen: The role of ROS
Authors: Stephan Octavian O. H. 
Published: January 2024

AbstractThe concept of ‘hormesis’ is defined as a dose–response relationship whereby low doses of various toxic substances or physical stressors trigger bio‐positive effects in diverse biological systems, whereas high doses cause inhibition of cellular performance (e.g. growth, viability). The two‐sided phenomenon of specific low‐dose stimulation and high‐dose inhibition imposed by a ‘hormetic‐factor’ has been well documented in toxicology and pharmacology. Multitudinous factors have been identified that correspondingly cause hormetic effects in diverse taxa of animals, fungi, and plants. This study particularly aims to elucidate the molecular basis for stimulatory implications of ionizing radiation (IR) on plant male gametophytes (pollen). Beyond that, this analysis impacts general research on cell growth, plant breeding, radiation protection, and, in a wider sense, medical treatment. For this purpose, IR‐related data were surveyed and discussed in connection with the present knowledge about pollen physiology. It is concluded that IR‐induced reactive oxygen species (ROS) have a key role here. Moreover, it is hypothesized that IR‐exposure shifts the ratio between diverse types of ROS in the cell. The interrelation between ROS, intracellular Ca2+‐gradient, NADPH oxidases, ROS‐scavengers, actin dynamics, and cell wall properties are most probably involved in IR‐hormesis of pollen germination and tube growth. Modulation of gene expression, phytohormone signalling, and cellular antioxidant capacity are also implicated in IR‐hormesis.
Elder abuse, depression, anxiety, and stress in community‐dwelling older adults
Authors: Yalçın Gürsoy Melike , Uçan Yamaç Sabriye 
Published: January 2024

AbstractBackgroundElder abuse as an important public health issue is associated in the literature with various physical and psychological symptoms. The aim of the study is to determine the relationship between elder abuse and depression, anxiety, and stress in the elderly living in the community.MethodThe cross‐sectional study was completed with 729 older people. Data were collected through a face‐to‐face interview and a survey form. The Geriatric Mistreatment Scale (GMS) was used to evaluate elder abuse and the Depression Anxiety Stress Scale‐21 (DASS‐21) was used to evaluate depression, anxiety, and stress. Multivariate regression analysis was performed to determine the relationship between elder abuse and depression, anxiety, and stress.ResultsOf the participants, 20.9% were exposed to at least one type of abuse, 9.2% experienced physical abuse, 18.2% experienced psychological abuse, 4.4% experienced neglect, and 7.0% had financial abuse. The general prevalence of moderate to very severe depression, anxiety, and stress among the elderly was respectively 17.1%, 16%, and 10%. As a result of multivariate analysis it was determined that neglect (t = 6245; ß = 4952) and economic abuse (t = 3865; ß = 3350) had statistically significant effects on depression; psychological abuse (t = 2924; ß = 0,992), economic abuse (t = 3127; ß = 3517) and neglect (t = 5913; ß = 4810) had statistically significant effects on anxiety, while psychological (t = 5023; ß = 1756) and economic abuse (t = 5719; ß = 5238) had statistically significant effects on stress (P < 0.05).ConclusionAs a result of the study, it was seen that the prevalence of abuse and depression, anxiety, and stress was high in the elderly. There was also a strong relationship between types of elder abuse and depression, anxiety, and stress. It is recommended that health professionals working with older people to screen them for types of abuse and mental symptoms with the help of appropriate screening tools.
Development of alternative diagnosis of HH1, HH3, HH5 and HCD fertility haplotypes and subfertility syndrome in cattle
Authors: Shormanova Marzhan , Makhmutov Abzal , Shormanova Aizhamal , Muslimova Zhadyra , Ussenbekov Yessengali 
Published: January 2024

AbstractThe increasing prevalence of hereditary anomalies in Holstein cattle populations presents a pressing issue, leading to concerns such as embryonic mortality and the birth of non‐viable offspring. This study addresses the urgency of managing harmful genetic mutations in Holstein cattle by developing alternative diagnostic methods. The research aims to devise effective means to diagnose fertility haplotypes HH1, HH3, HH5, HCD and BY and subfertility syndrome in cattle. To achieve this goal, a range of molecular genetic techniques were employed, including Tetra‐Primer ARMS‐PCR methods, PCR‐RFLP analysis and allele‐specific PCR. These methods facilitated the identification of heterozygous carriers of various fertility haplotypes and subfertility syndrome in Holstein cows and servicing bulls. The study reveals the prevalence of these genetic defects within the Republic of Kazakhstan's cattle population. HH1, HH3, HH5, HCD and BY fertility haplotypes were found to have occurrence rates ranging from 1.4% to 16.6%, with subfertility syndrome detected in 4.5% of Simmental bulls. The practical significance of this research lies in its contribution to genetic monitoring and management strategies for Holstein cattle populations. By introducing affordable, rapid and accurate diagnostic methods, such as the T‐ARMS‐PCR, the study provides a valuable tool for controlling and mitigating the spread of harmful genetic mutations, ultimately improving the overall genetic health and productivity of Holstein cattle in the region. This research addresses a critical need in the cattle breeding industry and underscores the importance of genetic monitoring to ensure the long‐term viability and sustainability of Holstein cattle populations.
Global well‐posedness and long‐time behavior in a tumor invasion model with cross‐diffusion
Authors: Jin Chunhua 
Published: January 2024

AbstractThis paper is concerned with a cross‐diffusion tumor invasion model with double‐taxis effect. We first investigate the global existence of classical solutions of this model in two‐dimensional space. The essential difficulty lies in the second‐level taxis effect of immune cells on tumor cells, where chemotactic factor (tumor cells) exhibit their own taxis behavior, the double‐taxis effect makes us have to use more detailed analysis and calculation, and some new estimation techniques are used. Subsequently, we also investigate the stability of some equilibria. For small proliferation coefficient, we prove the global asymptotic stability or local asymptotic stability of a semitrivial equilibrium point. While, for the other equilibria, the stability analysis is complicated even for some special cases, and both the double chemotactic coefficients will affect the stability of the solution.
The Professional Nurse Self‐Assessment Scale II – Translation and cultural adaptation for Nordic countries
Authors: Anåker Anna , Fagerström Lisbeth , Wangensteen Sigrid , Andersen Irene Aasen , Henriksen Jette , Svavarsdóttir Margrét Hrönn , Thorsteinsson Hrund Scheving , Strandell‐Laine Camilla 
Published: January 2024

AbstractBackgroundIt is important to map the clinical competence of newly graduated nurses in Nordic countries. The use of a common Nordic instrument could provide insights into nurses' levels of self‐assessed clinical competence and perceptions of their need for professional development.AimTo translate and culturally adapt the original Norwegian version of the Professional Nurse Self‐Assessment Scale II (PROFFNurse SAS II) into (1) Danish, (2) Finnish and (3) Icelandic versions.MethodThe PROFFNurse SAS II was translated and cross‐culturally adapted. This translation was inspired by the process used in the Guidelines for Cross‐Cultural Adaptation.ResultThe translation and cultural adaptation processes employed the required steps and provided specific details. In addition, practical issues encountered during the translation process while translating and adapting instruments that may influence future translations were revealed. This study found that having a professional bilingual/bicultural agency translator was partly problematic in the process of translation and found that it is important to adjust the translations to each country's specific words used in nursing.ConclusionTranslating the PROFFNurse SAS II instrument into all Nordic languages enables us to use the instrument from a Nordic perspective and across various countries. This is important when comparing self‐awareness and reflecting on nurses' clinical competencies. Professional development is central to valuing and developing clinical competence and allowing for the discovery of gaps in clinical competence.
A sports‐related injury prevention program for Dutch youth volleyball players: Process evaluation alongside a quasi‐randomized controlled trial
Authors: Nauta Joske , de Klerk Cindy , van Nassau Femke , Kemler Ellen , Zuidema Victor , de Wit Jacqueline , Verhagen Evert , Vriend Ingrid 
Published: January 2024

AbstractObjectiveThis process evaluation aimed to gain insight into the implementation of the VolleyVeilig Youth program by Dutch volleyball clubs within the context of an effectiveness trial.MethodsWe applied the UK Medical Research Council framework for process evaluations and assessed the context, implementation and mechanisms of impact. Trainers participating in the effectiveness trial were asked to complete a questionnaire at the end of the study. A subsample of the trainers based on the self‐reported adherence score was invited to participate in an interview accordingly. We used a thematic analysis to present the data.ResultsThirty‐one trainers (100%) completed the questionnaire, and seven agreed to participate in an interview. Although adherence gradually decreased over the volleyball season, most trainers reported partially adhere with the program until the end of the study. The main themes included factors associated with the (1) VolleyVeilig Youth program, (2) trainer, (3) players, and (4) volleyball club.ConclusionAlthough (partial) adherence to the VolleyVeilig Youth program was high in this study, implementation strategies must be developed to target the barriers reported by the trainers before the program can be successfully implemented nationwide in the Netherlands.
Metabolite‐mediated adaptation of crops to drought and the acquisition of tolerance
Authors: Zhang Fei , Rosental Leah , Ji Boming , Brotman Yariv , Dai Mingqiu 
Published: January 2024

SUMMARYDrought is one of the major and growing threats to agriculture productivity and food security. Metabolites are involved in the regulation of plant responses to various environmental stresses, including drought stress. The complex drought tolerance can be ascribed to several simple metabolic traits. These traits could then be used for detecting the genetic architecture of drought tolerance. Plant metabolomes show dynamic differences when drought occurs during different developmental stages or upon different levels of drought stress. Here, we reviewed the major and most recent findings regarding the metabolite‐mediated plant drought response. Recent progress in the development of drought‐tolerant agents is also discussed. We provide an updated schematic overview of metabolome‐driven solutions for increasing crop drought tolerance and thereby addressing an impending agricultural challenge.
Peripheral blood stem cell collection: Are midline catheters a viable alternative to central venous catheters?
Authors: Tran Minh‐Ha , Tajonera Eduardo 
Published: January 2024

AbstractBackgroundVascular access is a rate‐limiting step for peripheral blood stem cell collection. In the absence of readily accessible superficial veins, placement of tunnelled or non‐tunnelled central venous catheters (CVCs) is common. These invasive access routes create medical risks for patients and are associated with logistical challenges, thus prompting a search for alternatives. One such option is the off‐label use of midline catheters.Study design and methodsWe carried out a literature search for published experience with the use of midline catheters for peripheral blood stem cell collection. Data extracted included whether collections were allogeneic or autologous, donor sex, age and weight, inlet flow rate, total blood volumes (TBV) processed, collection duration, number of collections per donor, and achievement of collection targets.ResultsThe search produced three reports (one in abstract form) comprising 19 patients and 26 collection events. Donor sex and status were provided for 18 patients; 10 were female, 8 were male, 12 were allogeneic, and 6 autologous. Median (range) for: donor age was 28 (12–59); donor body weight (kg) was 77.5 (45.4–113.4); inlet flow rate (in mL/min) was 66 (28–80); TBV processed (in mL) was 15,880 (6178–21,871); collection duration (in hours) was 5.0 (3.2–7.0); and CD34 × 106/kg collection yield was 5.9 (3.6–23.0). Target CD34 yields were achieved in 14/19 (74%) of donors with 7/19 (37%) requiring two collections days.DiscussionPeripheral blood stem cell collection does appear to be viable via midline‐based catheter access, particularly for allogeneic donors and shorter collection courses. Development of institution‐specific guidelines and care pathways are recommended.
Effect of proteasome inhibitors on canine lymphoma cell response to CHOP chemotherapy in vitro
Authors: Prevedel Nicholas E. , Mee Miles W. , Wood Geoffrey A. , Coomber Brenda L. 
Published: January 2024

AbstractThe standard treatment for canine lymphoma is the CHOP chemotherapy regimen. Proteasome inhibitors have been employed with CHOP for the treatment of human haematological malignancies but remain to be fully explored in canine lymphoma. We identified an association between poor response to CHOP chemotherapy and high mRNA expression levels of proteasomal subunits in a cohort of 15 canine lymphoma patients, and sought to determine the effect of proteasome inhibitors on the viability of a canine B‐cell lymphoma cell line (CLBL‐1). The aim of this study was to investigate whether proteasome inhibitors sensitize these cells to the CHOP agents doxorubicin, vincristine and cyclophosphamide (as 4‐hydroxycyclophosphamide/4‐HC). CLBL‐1 cells were sensitive to proteasome inhibition by bortezomib and ixazomib. The IC50 of bortezomib was 15.1 nM and of ixazomib was 59.14 nM. Proteasome inhibitors plus doxorubicin had a synergistic effect on CLBL‐1 viability; proteosome inhibitors plus vincristine showed different effects depending on the combination ratio, and there was an antagonistic effect with 4‐HC. These results may have clinical utility, as proteasome inhibition could potentially be used with a synergizing CHOP compound to improve responsiveness to chemotherapy for canine lymphoma patients.
Prevalence and Health Associations of Meeting the World Health Organization Guidelines for Physical Activity, Sedentary Behavior, and Sleep in Preschool-Aged Children: The SUNRISE Mongolia Pilot and Feasibility Study
Authors: Byambaa Ankhmaa , Dechinjamts Oyundelger , Jambaldorj Bayasgalan , Jones Rachel A. , Chong Kar Hau , Okely Anthony D. 
Published: January 2024

Background: There is a lack of evidence regarding 24-hour movement behaviors of young children from low- and middle-income countries. This study examined Mongolian preschoolers’ adherence to the World Health Organization’s guidelines for physical activity, sedentary behavior, and sleep; their associations with health indicators, and the feasibility of the SUNRISE International study in Mongolia. Methods: Preschool-aged children were recruited from 5 kindergartens in urban and rural areas of Ulaanbaatar city and Tuv province in Mongolia. Physical activity and sedentary behavior were measured by an ActiGraph accelerometer worn for 5 consecutive days. Screen time and sleep were reported by parents. The National Institute of Health and Early Years Toolboxes were used to assess motor skills and executive function, respectively. Results: One hundred and one children participated in the study (mean age = 4.82 y, boys = 58), with 88% (n = 89) having complete data for analysis. The proportion of children who met the recommendations for physical activity, sedentary screen time, and sleep was 61%, 23%, and 82%, respectively. Only 7% met all recommendations. Meeting the sleep recommendation individually (P = .032) and in combination with the physical activity recommendation was associated with better gross (P = .019) and fine (P = .042) motor skills. Spending more time in physical activity was positively correlated with motor development. Results confirmed that the SUNRISE study protocol was feasible, age-appropriate, and enjoyable for children. Conclusions: The results of the SUNRISE pilot study will help inform the SUNRISE Mongolia main study and lay the groundwork for future research into children’s 24-hour movement behaviors in Mongolia.