bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feedback Processing as it Relates to Suicidal Ideation and Behavior Using a Time-Frequency Approach
Authors: Pavuluri Asha , Ellis Jessica , Vivino Anthony , Butler Devin , Arenson Melanie , Joiner Thomas , Schmidt Brad , Bernat Edward 
Published: December 2023

AbstractBackgroundSuicidal ideation (SI) and suicidal behavior (SB) may have different etiological pathways, particularly related to feedback processing. Identifying ERP components related to these suicide states may help researchers localize and understand these differences.Objective.Our primary purpose was to utilize time-frequency decomposition techniques to assess neurophysiological correlates of SI and SB during positive and negative feedback processing.Methods271 subjects (55.7% female; mean age=35.75, SD=16.07; 30.6% veterans) completed a questionnaire battery and a multi-task protocol, including a gambling feedback task (Gehring & Willoughby, 2002), while electroencephalography (EEG) was collected using a 96-channel EEG system. Exploratory factor analysis (EFA) was conducted across 20 self-report suicide items selected to index SI and SB from several suicide-relevant questionnaires. EFA results produced 2 factors, corresponding to SI and SB. Time-frequency principal component analyses produced measures across all frequency bands (i.e., delta-FN/P3, delta-SW, theta-FN, alpha, beta-1, beta-2, and gamma).ResultsExcepting alpha amplitude, all measured frequencies were related to SB, and not SI (across loss and gain, with some loss-gain differences). Alpha, uniquely, showed a relationship to SI and not to SB (across loss and gain, no loss-gain differences). Robust regressions confirmed that the delta, theta, and high-frequency (HF; beta-1, beta-2, and gamma as combined HF loss, gain, and loss-gain difference factors) measures were each independently related to SB.DiscussionBroadly, the results indicate that individuals with SB showed heightened neurophysiological response across multiple ERP components (except alpha) to gambling feedback, with significantly greater increases to loss stimuli relative to gain stimuli.General Scientific SummaryThis study, using time-frequency EEG/ERP measures from a gambling feedback task, supports the theoretical framework that suicidal behavior and suicidal ideation can be indexed separately. Generally, stronger reactivity to all feedback (i.e., loss and gain feedback during a gambling task) is seen in those with suicidal behavior and not in those with suicidal ideation, but with a small separate effect related to suicidal ideation.
Characterizing mobility patterns and malaria risk factors in semi-nomadic populations of Northern Kenya
Authors: Meredith Hannah R. , Wesolowski Amy , Okoth Dennis , Maraga Linda , Ambani George , Chepkwony Tabitha , Abel Lucy , Kipkoech Joseph , Lokoel Gilchrist , Esimit Daniel , Lokemer Samuel , Maragia James , O’Meara Wendy Prudhomme , Obala Andrew A. 
Published: December 2023

AbstractWhile many studies have characterized mobility patterns and disease dynamics of individuals from settled populations, few have focused on more mobile populations. Highly mobile groups are often at higher disease risk due to their regular movement that may increase the variability of their environments, reduce their access to health care, and limit the number of intervention strategies suitable for their lifestyles. Quantifying the movements and their associated disease risks will be key to developing intervention strategies more suitable for mobile populations. Here, we worked with four semi-nomadic communities in Central Turkana, Kenya to 1) characterize mobility patterns of travelers from semi-nomadic communities and 2) test the hypothesis that semi-nomadic individuals are at greater risk of exposure to malaria during seasonal migrations than when staying at their semi-permanent settlements. From March-October, 2021, we conducted a study in semi-nomadic households (n=250) where some members traveled with their herd while others remained at the semi-permanent settlement. Participants provided medical and travel histories, demographics, and a dried blood spot for malaria testing before and after the travel period. Further, a subset of travelers was given GPS loggers to document their routes. Four travel patterns emerged from the logger data, Long Term, Transient, Day trip, and Static, with only Long Term and Transient trips being associated with malaria cases detected in individuals who carried GPS devices. After completing their trips, travelers had a higher prevalence of malaria than those who remained at the household (9.2% vs 4.4%), regardless of gender, age group, and catchment area. These findings highlight the need to develop intervention strategies amenable to mobile lifestyles that can ultimately help prevent the transmission of malaria.
Correlation of Social Determinants of Health and Chronic Nonspecific Low Back Pain; A Brief Report
Authors: Ebrahimi Alireza , Rhee Hyunjoon , Taseh Atta , Rhim Hye Chang , Ashkani-Esfahani Soheil 
Published: December 2023

AbstractBackgroundLow back pain (LBP) ranks as one of the top contributors to disability-adjusted life years worldwide. Social determinants of health (SDoH) encompass a range of factors that play a pivotal role in shaping healthcare outcomes. We aimed to examine the differences in SDoH between patients with acute and chronic non-specific low back pain (NSLBP).MethodsThis study was a retrospective case-control study on patients who were admitted to four tertiary hospitals affiliated with Massachusetts General Hospital. Relevant ICD-9 and ICD-10 codes were used to detect patients with LBP. Patients with specific diagnoses such as degenerative joint diseases or primary or secondary bone tumors were excluded. SDoH variables along with the Social Vulnerability Index (SVI) and Area Deprivation Index (ADI) were collected. Wilcoxon rank sum and Chi-square tests were performed to assess the difference between the cohorts.ResultsOf 2,278 patients who were labeled as chronic LBP, 17 were included. The number of female patients was significantly higher (P < 0.05). Furthermore, we didn’t observe any considerable difference between these two groups of patients regarding the SDoH, SVI, and ADI values.ConclusionThe prevalence of chronic NSLBP in tertiary healthcare centers might be lower. SDoH, ADI, and SVI seem not to contribute to the chronicity of NSCLBP. Future research is needed to further our understanding of the risk factors associated with NSLBP, particularly in different healthcare settings.Significance/ImplicationsAlthough, SDoH variables are mentioned as risk factors, considering the clinical setting when applying the knowledge seem to play an important role.
The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease
Authors: Ehrler Melanie , Speckert Anna , Kretschmar Oliver , O’Gorman Ruth Tuura , Latal Beatrice , Jakab Andras 
Published: December 2023

AbstractCongenital heart disease (CHD) is known to negatively affect brain development. Individual clinical factors have been identified to contribute to this detrimental effect, however, the cumulative effect of these factors on brain development and neurodevelopmental outcomes are not fully understood. Our study utilized structural brain connectomics as an indicator of brain development to investigate the potential combined impact of clinical risk factors and family-environmental factors in adolescents with CHD.We developed a cumulative clinical risk (CCR) score by summing up binary risk factors (neonatal, cardiac, neurologic) based on clinically relevant thresholds and further investigated the role of family-environmental factors (parental education, parental mental health, and family function). Brain development in 53 adolescents with CHD who underwent infant open-heart surgery, and 75 healthy controls was studied by diffusion MRI connectomic analysis and neuropsychological assessments. The CCR score explains a great variability of the structural brain connectome. A higher CCR score was associated with lower network segregation, edge strength, and executive functioning. Edge strength was particularly reduced in an inter-frontal and fronto-parietal-thalamic network. There was no association with family-environmental factors. Poorer executive functioning was associated with lower network integration and segregation.Our results provide evidence for persisting alterations of network connectivity in adolescents with CHD – particularly in those patients who face a cumulative exposure to multiple clinical risk over time. Quantifying the cumulative load of risk early in life, may help to better predict trajectories of brain development in order to identify and support the most vulnerable patients as early as possible.
Focal Usual Interstitial Pneumonia-like Fibrosis is a Core Prognostic Factor in Progressive Pulmonary Fibrosis
Authors: Tsushima Yukio , Okoshi Ethan N. , Ishijima Sousuke , Bychkov Andrey , Lami Kris , Morimoto Shimpei , Yamano Yasuhiko , Kataoka Kensuke , Johkoh Takeshi , Kondoh Yasuhiro , Fukuoka Junya 
Published: December 2023

ABSTRACTProgressive pulmonary fibrosis (PPF) is a newly recognized clinical phenotype of interstitial lung diseases in the 2022 interstitial pulmonary fibrosis (IPF) guidelines. This category is based entirely on clinical and radiological factors, and the background histopathology is unknown. Our objective was to investigate the histopathological characteristics of PPF and to examine the correlation between usual interstitial pneumonia (UIP) and prognosis in this new disease type. We hypothesized that the presence of UIP like fibrosis predicts patients’ survival in PPF cases.We selected 201 cases fulfilling the clinical criteria of PPF from case archives. Cases diagnosed as IPF by a multidisciplinary team were excluded. Whole slide images were evaluated by three pathologists who were blind to clinical and radiological data. We measured areas of UIP-like fibrosis and calculated what percentage of the total lesion area they occupied.The presence of focal UIP-like fibrosis amounting to 10% or more of the lesion area was seen in 148 (73.6%), 168 (83.6%), and 165 (82.1%) cases for each pathologist respectively. The agreement of the recognition of UIP-like fibrosis in PPF cases was above κ = 0.6 between all pairs. Survival analysis showed that the presence of focal UIP-like fibrosis correlated with worsened survival under all parameters tested (p < 0.001).The presence of UIP-like fibrosis is a core pathological feature of clinical PPF and its presence within diseased areas is associated with poorer prognosis. This study highlights the importance of considering the presence of focal UIP like fibrosis in the evaluation and management of PPF.
An amplicon-based Illumina and nanopore sequencing workflow for Chikungunya virus West Africa genotype
Authors: Dieng Idrissa , Ndiaye Mignane , Kane Mouhamed , Balde Diamilatou , Mbanne Maimouna , Diop Seynabou Mbaye Ba Souna , Sankhe Safietou , Dia Moussa , Dieng Madeleine , Doukanda Serge Freddy Moukaha , Faye Ousmane , Sall Amadou Alpha , Dia Ndongo , Fall Gamou , Faye Oumar , Diagne Moussa Moise 
Published: December 2023

AbstractThe Chikungunya virus, a global arbovirus, is currently causing a major outbreak in the Western African region, with the highest cases reported in Senegal and Burkina Faso. Recent molecular evolution analyses reveal that the strain responsible for the epidemic belongs to the West African genotype, with new mutations potentially impacting viral replication, antigenicity, and host adaptation. Real-time genomic monitoring is needed to track the virus’s spread in new regions. A scalable West African genotype amplicon-based Whole Genome Sequencing for multiple Next Generation Sequencing platforms has been developed to support genomic investigations and identify epidemiological links during the virus’s ongoing spread. This technology will help identify potential threats and support real-time genomic investigations in the ongoing spread of the virus.
The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study
Authors: Fu Wei , zhao Junlong , Chen GuoBin , Lyu Linya , Ding Yao , Xu Liang-Bi 
Published: December 2023

ABSTRACTBackgroundThe Triglyceride-glucose (TyG) index is an emerging marker for insulin resistance and metabolic syndrome. Helicobacter pylori, a bacterium associated with gastrointestinal diseases, may also influence metabolic risk profiles. This study aimed to investigate the relationship between the TyG index and Helicobacter pylori infection among a representative sample of adults.MethodsA total of 9965 participants from the NHANES 1999-2000 cycle were involved from March 1, 1999, to December 1, 2000.A cross-sectional analysis was conducted on 3797 participants. The baseline characteristics according to the quartile of the TyG index were evaluated.Multivariate binary logistic regression models were constructed to analyze the independent effects of the TyG index on Helicobacter pylori infection. A two-piecewise binary logistic regression model was used to explore the non-linear relationship between the TyG index and Helicobacter pylori, with an inflection point identified. Subgroup analyses were performed to assess the trends of effect sizes across different variables including age, sex, glucose levels, body mass index (BMI), and chronic kidney disease (CKD).ResultsMultivariate analysis indicated a linear relationship between the TyG index and Helicobacter pylori infection, suggesting differential influence of the TyG index on Helicobacter pylori infection. Subgroup analysis demonstrated significant interactions only for a few variables, with all p-values for interaction below 0.05.ConclusionsThe study suggests a linear association between the TyG index and Helicobacter pylori infection.These findings have implications for understanding the metabolic influences on Helicobacter pylori infection and may guide targeted interventions for at-risk populations.
Longitudinal Assessment of Mental Health in Antarctica Expeditioners
Authors: Nagendran S , Ahmad Aftab , Nath Ravindra , Nangalia Shalini , Maurya Chandrakant , Dutt D Ganga , Kanojia Aakash 
Published: December 2023

AbstractAntarc’ca is known for its harsh climate and long, dark winters. Scien’sts and support staff posted in various base sta’ons in Antarc’ca face unique challenges, which include social isola’on, lack of communica’on from the outside world and prolonged working hours. This may lead to changes in their mental health status during their pos’ng. A longitudinal observa’onal study is planned to evaluate the mental health status and changes in it among the Antarc’c expedi’oners. A detailed protocol is presented in this paper.
Analysis of bacteria, inflammation, and exudation in epidermal suction blister wounds reveals dynamic changes during wound healing
Authors: Lundgren Sigrid , Petruk Ganna , Wallblom Karl , Cardoso José FP , Strömdahl Ann-Charlotte , Forsberg Fredrik , Luo Congyu , Nilson Bo , Hartman Erik , Fisher Jane , Puthia Manoj , Saleh Karim , Schmidtchen Artur 
Published: December 2023

AbstractThe skin microbiome undergoes dynamic changes during different phases of wound healing, however the role of bacteria in the wound healing process remains poorly described. In this study, we aimed to determine how wound bacteria develop over time in epidermal wounds, and how they interact with inflammatory processes during wound healing. To this end, we analyzed wound fluid and swab samples collected from epidermal suction blister wounds in healthy volunteers. We found that bacterial numbers, measured in swabs and dressing fluid, increased rapidly after wounding and stabilized by day 8. The composition of bacterial species identified by MALDI-TOF mass spectrometry differed between wounds, but generally consisted primarily of commensal bacteria and remained largely stable over time. Inflammation and neutrophil activity, measured by quantification of cytokines and neutrophil proteins in dressing fluid, peaked on day 5. Exudation, measured by quantification of protein content in dressings, also peaked at this time and strongly correlated with cytokine and neutrophil protein levels. Inflammation, neutrophil activity, and exudation were not correlated with bacterial counts at any time, indicating that in normally healing wounds, these processes are primarily driven by the host and are independent of colonizing bacteria. Our analysis provides a comprehensive understanding of epidermal wound healing dynamics in the host and the role of the microbiome in healthy wound healing.
Investigating the Nature of Open Science Practices Across Complementary, Alternative, and Integrative Medicine Journals: An Audit
Authors: Ng Jeremy Y. , Lin Brenda , Parikh Tisha , Cramer Holger , Moher David 
Published: December 2023

AbstractBackgroundOpen science practices are implemented across many scientific fields to improve transparency and reproducibility in research. Complementary, alternative, and integrative medicine (CAIM) is a growing field that may benefit from adoption of open science practices. The efficacy and safety of CAIM practices, a popular concern with the field, can be validated or refuted through transparent and reliable research. Investigating open science practices across CAIM journals by using the Transparency and Openness Promotion (TOP) guidelines can potentially promote open science practices across CAIM journals. The purpose of this study is to conduct an audit that compares and ranks open science practices adopted by CAIM journals against TOP guidelines laid out by the Center for Open Science (COS).MethodsCAIM-specific journals with titles containing the words “complementary”, “alternative” and/or “integrative” were included in this audit. Each of the eight TOP criteria were used to extract open science practices from each of the CAIM journals. Data was summarized by the TOP guideline and ranked using the TOP Factor to identify commonalities and differences in practices across the included journals.ResultsA total of 19 CAIM journals were included in this audit. Across all journals, the mean TOP Factor was 2.95 with a median score of 2. The findings of this study reveal high variability among the open science practices required by journals in this field. Four journals (21%) had a final TOP score of 0, while the total scores of the remaining 15 (79%) ranged from 1 to 8.ConclusionWhile several studies have audited open science practices across discipline-specific journals, none have focused on CAIM journals. The results of this study indicate that CAIM journals provide minimal guidelines to encourage or require authors to adhere to open science practices and there is an opportunity to improve the use of open science practices in the field.
Exploring best practice governance for EU-funded health research consortia: A qualitative study protocol for insight and ideation
Authors: Renker-Darby Ana , Bärnighausen Till , Neumann Christine , Preet Raman , Treskova Marina 
Published: December 2023

AbstractBackgroundInternational consortia have emerged as a common model to organise and fund large-scale, multi-disciplinary research in contemporary health and biomedical science. The diversity of participants, size and complexity of these consortia necessitates effective governance to achieve their research aims and societal impact. For health research consortia funded by the European Union, certain governance structures and processes have emerged out of convention. However, there is limited scientific evidence to support their use, and little is known about consortia participants’ perspectives on how governance structures could be improved to better serve the implementation of research. In this paper, we present a protocol for a qualitative study to explore the perspectives of participants in European Union-funded health research consortia on the value of governance structures and how they might be improved.Methods and analysisWe will conduct a qualitative study using in-depth interviews with participants in health research consortia funded by the European Union. We will recruit participants following a purposeful sampling approach, and recruitment will continue until saturation is reached. During in-depth interviews, we will ask participants about how the governance of consortia is structured and what is working well or poorly about those governance structures from their perspective. We will draw on design thinking methods to help participants to ideate improvements in governance structures. Data will be analysed using a thematic analysis approach.DiscussionFindings from this study will provide valuable evidence for developing and formulating governance structures for health research consortia. The findings of this work may also contribute to guidelines for consortium proposal submissions.
Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk
Authors: Lee Ming-Ming , Zuo Yi , Steiling Katrina , Mizgerd Joseph P. , Kalesan Bindu , Walkey Allan J. 
Published: December 2023

ABSTRACTBackgroundChronic inflammation may increase susceptibility to pneumonia.Research QuestionTo explore associations between clinical comorbidities, serum protein immunoassays, and long-term pneumonia risk.MethodsFramingham Heart Study Offspring Cohort participants ≥65 years were linked to their Centers for Medicare Services claims data. Clinical data and 88 serum protein immunoassays were evaluated for associations with 10-year incident pneumonia risk using Fine-Gray models for competing risks of death and least absolute shrinkage and selection operators for covariate selection.ResultsWe identified 1,370 participants with immunoassays and linkage to Medicare data. During 10 years of follow up, 428 (31%) participants had a pneumonia diagnosis. Chronic pulmonary disease [subdistribution hazard ratio (SHR) 1.87; 95% confidence interval (CI), 1.33-2.61], current smoking (SHR 1.79, CI 1.31-2.45), heart failure (SHR 1.74, CI 1.10-2.74), atrial fibrillation/flutter (SHR 1.43, CI 1.06-1.93), diabetes (SHR 1.36, CI 1.05-1.75), hospitalization within one year (SHR 1.34, CI 1.09-1.65), and age (SHR 1.06 per year, CI 1.04-1.08) were associated with pneumonia. Three baseline serum protein measurements were associated with pneumonia risk independent of measured clinical factors: growth differentiation factor 15 (SHR 1.32; CI 1.02-1.69), C-reactive protein (SHR 1.16, CI 1.06-1.27) and matrix metallopeptidase 8 (SHR 1.14, CI 1.01-1.30). Addition of C-reactive protein to the clinical model improved prediction (Akaike information criterion 4950 from 4960; C-statistic of 0.64 from 0.62).ConclusionsClinical comorbidities and serum immunoassays were predictive of pneumonia risk. C-reactive protein, a routinely-available measure of inflammation, modestly improved pneumonia risk prediction over clinical factors. Our findings support the hypothesis that prior inflammation may increase the risk of pneumonia.Summary or “take home” messageHere, we show that long-term pneumonia risks are associated with clinical characteristics and serum markers of inflammation. Our findings offer preliminary support to the hypothesis that chronic inflammation may be a marker of increased pneumonia risk.