bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Comparisons of Radiofrequency Ablation and different Surgical Procedures in Patients with Stage I Intrahepatic Cholangiocarcinoma: a Population-based Analysis
Authors: Zou Yiping , Cai Dianqi , Huang Jing , Li Zhifei , Guo Yu , Song Yuning , Chang Shaofei , Liang Yuexiang , Gao Song 
Published: October 2023

Abstract
Background
This study aims to investigate the impacts of different surgical procedures on the survival outcome of patients with early-stage intrahepatic cholangiocarcinoma (ICC).
Methods
We analyzed 1447 early-stage ICC patients retrieved from the SEER database. The Kaplan–Meier method with log-rank tests was used to assess the differences in survival. Univariate and multivariate Cox regression analyses were applied to adjust the confounding bias. Then, we performed subgroup analyses of Stage T1a and T1b patients.
Results
Minor or major resections show the best survival advantage in patients with early-stage ICC. However, patients who underwent extended resection and radiofrequency ablation offered a chance for long-term survival and exhibited significantly better survival than those without surgery. Subgroup analyses indicated that patients who underwent extended resection had better survival outcome compared to those who underwent radiofrequency ablation in Stage T1b patients but not in Stage T1a patients.
Conclusions
Minor or major resection is the prime surgical choice in patients with early-stage ICC. For patients who is unsuitable minor and major resection, it is recommended to perform extended resection in the Stage T1b subgroup and radiofrequency ablation in the Stage T1a subgroup.
Polyethylene Glycol Relieves Hangover by Reducing Alcohol Absorption through the Intestinal Wall
Authors: Ryu Tom , Yang Keungmo , Choi Byung Young , Cho Won Gil , Chung Beom Sun 
Published: October 2023

Abstract

Therapeutic options for hangover following alcohol consumption, a prevalent health problem worldwide, remain unavailable. This study investigated the effectiveness of polyethylene glycol (PEG) on hangovers using a mouse model. First, large quantities of alcohol (4 g/kg body weight) was administered to mice. Subsequently, PEG (2 g/kg body weight) or an equivalent volume of vehicle was administered orally after alcohol consumption. Acute alcohol consumption was found to damage not only the liver but also the small intestine, as noted in histological findings and mRNA expression analysis of inflammatory cytokines. We also identified impaired motor function in the mouse model of binge drinking. Interestingly, PEG drastically prevented injury and inflammation of the small intestine after binge drinking in mice. Furthermore, PEG had hepatoprotective effects, evident from decreased hepatic enzyme levels in the serum, diminished liver injury observed following H and E staining, and decreased infiltration of neutrophils within the liver. Taken together, these findings suggest that PEG administration with acute alcohol consumption may be an effective therapeutic option to prevent severe hangover symptoms or damage to certain organs.
Transcranial Alternating Current Stimulation for patient in ataxia-ocular apraxia 2: a case report
Authors: Cheng Xiao-Ping , Yu Wen-Hui , Liu Xia , Lin Wei , Wang Zhao-Di , Wang Xi-Chen , Ni Jun , Cai Nai-Qing , Chen Xin-Yuan 
Published: October 2023

Abstract
Ataxia-ocular apraxia 2 (AOA2) is a rare neurodegenerative autosomal recessive disorder with no effective treatment. In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent Transcranial alternating current stimulation (tACS) treatment for four weeks and was followed up after one month. The effectiveness of the treatment was evaluated using International Cooperative Ataxia Rating Scale ༈ICARS༉, Scale for the Assessment and Rating of Ataxia ༈SARA༉, the 9-Hole Peg Test ༈9HPT༉, and Functional near-infrared spectroscopy ༈fNIRS༉. Following the treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during the follow-up period, suggesting a lasting effect of tACS treatment. These findings from our case study provide compelling evidence for the potential of tACS as a treatment option for AOA2.
Altered dynamic functional connectivity of motor cerebellar with sensorimotor network and default mode network in Juvenile Myoclonic Epilepsy
Authors: Yang Menghan , Zhang Yingying , Zhang Tianyu , Zhou Huanyu , Ren Jiechuan , Zhou Dong , Yang Tianhua 
Published: October 2023

Abstract
Background
To investigate the role of dynamic functional connectivity (dFC) of motor cerebellar motor cerebellar-cortical circuitry in juvenile myoclonic epilepsy (JME).
Methods
The motor cerebellum is divided into five lobules (I–V, VI, VIIb, VIIIa, and VIIIb). We adopted the resting-state EEG-fMRI and the sliding-window approach to explore the dFC of motor cerebellum with SMN and DMN between30 JME patients compared with thirty sex-and age-matched health controls (HCs). Moreover, the relationship between the dFC variability and clinical variables (disease duration, age at disease onset, and frequency score of myoclonic seizures) were also investigated in JME group.
Results
Compared to HCs, the JME group presented increased dFC between the motor cerebellum with sensorimotor network(SMN)and default mode network (DMN). Specifically, connectivity between lobule Ⅶb and right precentral gyrus and left inferior parietal lobule (IPL); between lobule Ⅷa and right middle frontal gyrus (MFG) and left IPL; and between lobule Ⅷb and left MFG, bilateral superior parietal gyrus (SPG), and left precuneus. In addition, within the JME group, the strength of dFC between lobule Ⅷb and left precuneus was negatively (r=-0.424, p = 0.025, Bonferroni correction) related with the frequency score of myoclonic seizures.
Conclusion
JME presents altered dFC variability in motor cerebellum with SMN and DMN, and the strength of dFC between lobule Ⅷb and left precuneus is associated with the severity of JME. These results may provide novel information about the dynamic and wide involvement of the motor cerebellum in the pathophysiology of JME, specifically, the motor cerebellum is involved in motor symptoms.
Real-world efficacy of adjuvant therapy for totally resected stage I lung adenocarcinoma patients with pathological high-risk factors: Propensity score analysis
Authors: Zhao Ke , Yang Libing , Liu Lei , Wang Guige , Zhang Jiaqi , Gao Xuehan , Guo Chao , Huang Cheng , Li Shanqing , Chen Yeye 
Published: October 2023

Abstract

Background
We investigated the real-world efficacy of adjuvant therapy for stage I lung adenocarcinoma patients with pathological high-risk factors.
Methods
Study participants were enrolled from November 1, 2016 and April 30, 2022. Clinical bias was balanced by propensity score matching. Disease-free survival (DFS) outcomes were compared by Kaplan–Meier analysis. The Cox proportional hazards regression was used to identify survival-associated factors. p ≤ 0.05 was the threshold for statistical significance.
Results
A total of 658 patients, among whom 195 (29.6%) underwent adjuvant therapy, were enrolled in this study. One hundred and sixty-seven of the patients who underwent adjuvant therapy were well matched with non-treatment patients. Prognostic outcomes of the treatment group were significantly better than those of the non-treatment group, as revealed by Kaplan-Meier analysis before and after PSM. Differences in prevention of recurrence or metastasis between the targeted therapy and chemotherapy groups were insignificant. Patients with multiple risk factors, stage IB and who were non-smokers were more likely to benefit from adjuvant treatment. Adjuvant therapy was found to be positive prognostic factors.
Conclusions
Adjuvant therapy significantly improved the DFS for stage I lung adenocarcinoma patients with high-risk factors. Larger prospective clinical trials should be performed to verify our findings.
Idiopathic Nephrotic Syndrome in Syrian Children: Clinicopathological Spectrum, Treatment, and Outcome
Authors: wannous hala 
Published: October 2023

Abstract
Background: Idiopathic nephrotic syndrome (INS) is the most common glomerular disorder of childhood. We performed this study to report the histopathological findings, correlation between the clinical and histopathological features, with the response to steroids and other immunosuppressive drugs and outcome in Syrian children with INS.
Methods: A single-center observational cohort study was conducted at Children’s University Hospital in Damascus, included all patients aged 1 – 14 years, admitted from January 2013 to December 2022 with INS and underwent kidney biopsy.
Results: The study included 109 patients, with a male/female ratio of 1.13:1, and a mean age of 6.08 years ± 3.73 SD. The main indication of kidney biopsy was steroid-resistant nephrotic syndrome (SRNS) (57.8%). The main histopathological patterns were minimal change disease (MCD) (45%) and focal segmental glomerulosclerosis (FSGS) (37.6%). FSGS was the most common histopathological pattern in SRNS (44.3%). In SRNS, we used Tacrolimus in 49 patients with response rate of 69.4% and Cyclosporine in 20 patients with response rate of 50%. In steroid-dependent nephrotic syndrome (SDNS), we used MMF in 9 patients with response rate of 89% and Cyclophosphamide in 3 patients with response rate of 66.7%. Rituximab was used in four patients with FSGS, two SRNS patients and two SDNS patients, with response rate of 100% and continuous remission till now (more than two years). Fifteen patients (13.7%) progressed to chronic kidney disease stage V, of them 7 patients had FSGS and 8 patients had focal and global glomerulosclerosis, 14 patients of them were steroid resistant and one patient was steroid dependent, and all of them were resistant to immunosuppressants. The most common outcome was recovery (47%) in MCD and frequent relapses (31.7%) in FSGS.
Conclusions: FSGS was the most common histopathological pattern in idiopathic SRNS and has the worst prognosis. Tacrolimus is the most effective second-line therapy in SRNS. Rituximab is an effective and safe treatment that induces prolonged remission mainly in SDNS and frequently relapsing NS, and even in SRNS.
Risk assessment model for dust explosion in dust removal pipelines using an attention mechanism-based convolutional neural network
Authors: Li Yang , Cui Gaozhi , Han Qinglin , Chen Simeng , Lu Shuaishuai 
Published: October 2023

Abstract

Dust explosions occur frequently during production, transportation, and storage processes involving combustible dusts, with dust explosions caused by de-dusting systems being the most common. To prevent such accidents, we need to perform timely and accurate risk assessment. Therefore, we have developed a risk assessment model for dust explosion of dust duct deposition based on convolutional neural network with an attention mechanism (ConvNext-Tsc). By enhancing the ConvNext block and introducing an attention mechanism, we can more accurately extract the critical features related to the thickness of deposited dust in images of the ducts, achieving a model recognition accuracy of 95.15%. We have verified that the model has a high assessment accuracy in practical applications, which helps to detect potential hazards in dust ducts in time and avoid explosion accidents. The results show that the model has a wide range of application prospects in sedimentary dust explosion risk assessment, with high reliability, practicality, and scientific rigor.
Application of Predictive Model for Efficient Cassava (ManihotEsculanta) Yield in the Face of Climate Variability in Enugu State, Nigeria
Authors: Ogbuene Emeka Bright , Nwobodo Tonia Nkiru , Aloh Obianuju Gertrude , Okolo Obiageli Jacinta , Ozorme Vivian Amarachi , Achoru Fred , Ogbuka Josiah. C. 
Published: October 2023

Abstract
Climate variability as occasioned by conditions such as rainfall cessation, irregular and over stretched temperatures have considerable impact on crop yield and food security. This study develops a predictive model for cassava yield (manihotesculanta) amidst climate variability. This study utilized data of climate variables and tonnage of cassava yield as well as information from a questionnaire and focus group discussion with farmers. Regression analysis was employed to develop the predictive model for seasonal climate variability and cassava yield. The rainfall and temperature anomalies, decadal change in trend of cassava yield and opinion of farmers on changes in rainfall seasonwas also accessed.The result shows the following relationship between cassava and all the climatic variables: R2 = 0.939; P = 0.00514; Cassava and key climatic variables: R2 = 0.560; P = 0.007. The result of the predictive model equation is y = − 264637 + 0.237–1.073 + 077–4.402 + 2.636 + 5.250–8.658 + 2.054 + 1.956–4.831 + 0.978–0.591 + 11402.6. The result of the predictive model equation indicates that seasonal rainfall, temperature, relative humidity, sunshine hours and radiation parameters are key climatic variables in cassava production. This is supported by rainfall and temperature anomalies which identified that rainfall anomalies range from − 478.5 to 517.8mm while temperature anomalies range from − 1.2 to 2.3 0C over the years. The questionnaire and focus group identified that farmers experienced more late onset and early onset of rain and rainfall cessation over the years. The study made recommendations such as a comprehensive early warning system on climate variability incidence which can be communicated to local farmers by agro-meteorological extension officers.
Seasonal variability on cross-shore profile in meso-tidal settings due to lunar cycle effects in Kuala Terengganu Coast
Authors: Harris Muhammad Fadhli , Nadzri Muhammad Izuan , Yusof Ku Mohd Kalkausar Ku , Razak Wan Amrul Jaahiz Abd , Shukri Mohamad Hakim Mohd , Baharim Nor Bakhiah , Ali Azizi , Ariffin Effi Helmy 
Published: October 2023

Abstract

Kuala Terengganu, one of the coastal zones in Malaysia, is prone to natural hazard factors, such as coastal erosion. The impacts of coastal erosion alternate the morphological structure of the beach in Terengganu. The beach morphological changes were driven by the seasonal monsoon such as Northeast Monsoon (NEM) and Southwest Monsoon (SWM) season. Hence, to understand the short-temporal morphological response of meso-tidal beaches during spring tide events throughout the lunar cycle phase, the study was investigated in Batu Buruk beach, Kuala Terengganu. The tidal cycles, particularly during spring tide (Full Moon and New Moon phases) were collected from five transects starting on October 2020 to October 2021. The monitoring of cross-shore was conducted by using RTK to measure the cross-sectional area and sediment volume changes. The data collected were computed by using profiler 3.2XL software. Numerical modelling such as MIKE-21 was used to simulate tidal elevation within the period of this study. The study showed significant impact by the lunar cycle on sediment gain and loss. The cross-sectional analysis revealed positive sediment gains during the Full Moon. However, the New Moon erosion seemed to take place around the upper swash zone area. This provides an insight into the spring tide and contributes to beach recovery processes.
Synthesis and Characterization of Versatile Polymer Particles for the Adsorption of Bromophenol Blue and Phenol
Authors: Gokkus Kutalmis , Oter Cigdem , Amlani Merilyn , Gur Mahmut , Butun Vural 
Published: October 2023

Abstract
Removing anionic pollutants from water sources remains a major challenge in supramolecular chemistry. Today, cellulose, activated carbon, zeolite, and similar materials, which are widely preferred, have a weak effect against anionic pollutants. Therefore, further modifications are needed for the use of such substances. On the contrary, in this study, highly functional and economical polymeric particles (called GD particles) were synthesized with high yield and did not require further modifications. GD particles were synthesized with glutaraldehyde and diethylenetriamine as monomers for the first time. The structural properties of the synthesized particles were characterized by FT-IR, TGA, and SEM analyses. Then, GD particles were used in the adsorption of anionic Bromophenol blue and phenol. The isotherm, thermodynamic, and kinetic models were used to explain the adsorption mechanism between Bromophenol blue, phenol, and GD particles. Thus, it was determined that the adsorption process between GD particles and Bromophenol blue was chemisorption, and between phenol and GD particles, physical adsorption took place. It was determined that GD particles polymer particles had high adsorption capacities, such as 136.40 mg/g for bromophenol blue and 98.26 mg/g for phenol than natural adsorbents. As a result, it was produced economical, simple, feasible, and functional adsorbents against anionic pollutants.
From recycled PVC and its blends to eco-friendly materials for the footwear industry in Brazil: Insight into the process and evaluation of the mechanical properties
Authors: Marsura Giovanna , Bahú Juliana Otavia , Tovar Laura Plazas , Felisbino Romilda Fernandez , Gomes Eliezer Ladeia 
Published: October 2023

Abstract
Recycling and upcycling waste polyvinyl chloride (PVC) poses a major challenge to the footwear industry due to its short lifecycle and the environmental impact of destructive trends. This study aimed to recycle thermoplastic polyvinyl chloride (rPVC) from used sports shoes of the most varied kind, obtained from a recycling company. The rPVC and thermoplastic polyurethane (TPU) were melt-blended, prepared by industrial injection molding with different compositions, and the polymer blends were characterized by morphological, thermal, and mechanical means. The overall properties of the recycled polymer blends were improved compared to their parent commercial materials. When TPU and rPVC were blended, the resulting material displayed a remarkable hardness. The abrasion resistance of the TPU/rPVC polymer blends (67/33 and 50/50 wt.%) was enhanced twice compared to PVC, and the rPVC rupture strength (14.73 MPa) was 1.6 times greater than virgin PVC (9.11 MPa). Likewise, The TPU/rPVC blend (50/50% wt.%) also offered significantly greater deformation resistance, indicating that rPVC has a more entangled structure with greater resistance and, thus, greater tensile strength. Polymer blending is accelerating research and development in the footwear industry, and the outcomes have qualified the TPU/rPVC (67/33 and 50/50 wt.%) polymer blends to meet the growing consumer demand for environmentally friendly footwear.
Tropical mobola plum (Parinari curatellifolia): a full characterization of wood and bark within the scope of biorefineries
Authors: Malengue Abílio , Lourenço Ana , Patrício Helena , Costa Ricardo A. , Quilhó Teresa , Gominho Jorge 
Published: October 2023

Abstract
Parinari curatellifolia is the main species used to produce charcoal in Angola. It is chemical, anatomical, and thermal properties were analyzed. The bark is dark grey, rough, and corky, and the wood is brown to yellow-red. Compared to wood, bark fibers presented lower length, lumen, and wall thickness. There is not much difference between height and cell numbers of rays. Sieve tube elements appear solitary or in small groups (2–3 cells), and vessels were of two diameter classes but with diffuse-porous. Bark density was lower than wood (505 kg.m− 3 vs. 580 kg.m− 3). The mean chemical composition from bark vs. wood of P. curatellifolia was ash (3.2% vs. 1.6%), total extractives (12.2% vs. 10.0%), lignin (42.4% vs. 28.4%), and suberin 5.4%. Families identified by GC-MS from DCM extracts were predominated by fatty acids in wood and triterpenoid contents in bark. Bark and wood had higher antioxidant activity in FRAP and DPPH methods. The bark had a monomeric lignin composition richer in guaiacyl-units (25.9% vs. 22.5%) and lower syringyl-units (5.7% vs. 8.5%). Potassium was the most abundant mineral, while the least is cadmium in wood and bark. Regarding thermal properties, bark presented higher moisture content (9.0% vs. 8.0%), ash (3.33% vs. 1.61%), total volatiles (27.5% vs. 20.7%), lower fixed carbon (69.1% vs. 77.7%) and higher heating value (20.9 MJ/kg vs. 19.1 MJ/kg). According to these characteristics, both biomasses are interesting for developing more value-added products besides burning under the context of biorefineries.
HSV-1 infected microglia escape immune response by down-regulating TLR3-mediated innate immune response by GM130
Authors: Liu Jia , Chen Xiqian , Liu Junxian , Zhang Hainan , Lu Wei 
Published: October 2023

Abstract
Background and Aims:
To investigate the mechanism of GM130 regulating the antiviral immune response of TLR3 after HSV-1 infection of microglia cells. To explore the regulatoryof berberine on GM130 and TLR3 mediated immune response.
Method
The vitro model of HSV-1 infection was established by infecting BV2 cells with HSV-1. The protein levels of GM130 and TLR3 were detected by Immunoblotting. The secretion of inflammatory cytokines IFN-β, TNF-α and IL-6 was detected by enzyme-linked immunosorbent assay. The structural changes of Golgi apparatus were observed by immunofluorescence staining and transmission electron microscopy.
Results
Compared with the uninfected group, the Golgi apparatus fragmentation and GM130 in the HSV-1 infected group began to decrease at 6h; the level of TLR3 increased at 6h and began to decrease at 12h; the secretion of inflammatory cytokines IFN-β, TNF-α and IL-6 increased at 6h and 12h, but began to decrease at 24h afterinfection.In uninfected group, the Golgi apparatus was fragmented after GM130 knockdown, and the level of TLR3 was significantly reduced. In the HSV-1 infected group, GM130 knockdown aggravated the fragmentation of Golgi apparatus, and caused the level of TLR3 to further decrease, and the virus titer also increased significantly.In the HSV-1 infected group, over-expression of GM130 alleviated the Golgi fragmentation induced by HSV-1 and partially restored the level of TLR3.After GM130 knockdown in HSV-1 infection group, TLR3 excitant was added to partially restore the level of TLR3 and the secretion level of inflammatory factors.After GM130 over-expression in the HSV-1 infected group, treatment with TLR3 inhibitor TLR3i inhibited TLR3 levels and inflammatory factor secretion. Berberine can protect the Golgi apparatus and reverse the down-regulation of GM130 levels, as well as reverse the down-regulation of TLR3 and its downstream factor factorsafter HSV-1 infection, reducing the virus titer.
Conclusion
In microglia, HSV-1 infection induced Golgi stress response and decreased level of GM130.GM130 affects the secretion levels of inflammatory cytokines IFN-β, TNF-α and IL-6 and viral replication by regulating the levels of TLR3. Berberine protects the Golgi apparatus and enhances TLR3 mediated antiviral immune response.