bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of willingness to share health data with key stakeholders in US consumers: a latent class analysis
Authors: Nagappan Ashwini , Zhu Xi 
Published: January 2025

Abstract

Objective
To identify distinct patterns in consumer willingness to share health data with various stakeholders and analyze characteristics across consumer groups.

Materials and Methods
Data from the Rock Health Digital Health Consumer Adoption Survey from 2018, 2019, 2020, and 2022 were analyzed. This study comprised a Census-matched representative sample of U.S. adults. Latent class analysis (LCA) identified groups of respondents with similar data-sharing attitudes. Groups were compared by sociodemographics, health status, and digital health utilization.

Results
We identified three distinct LCA groups: (1) Wary (36.8%), (2) Discerning (47.9%), and (3) Permissive (15.3%). The Wary subgroup exhibited reluctance to share health data with any stakeholder, with predicted probabilities of willingness to share ranging from 0.07 for pharmaceutical companies to 0.34 for doctors/clinicians. The Permissive group showed a high willingness, with predicted probabilities greater than 0.75 for most stakeholders except technology companies and government organizations. The Discerning group was selective, willing to share with healthcare-related entities and family (predicted probabilities &gt;0.62), but reluctant to share with other stakeholders (predicted probabilities &lt;0.29). Individual characteristics were associated with LCA group membership.

Discussion
Findings highlight a persistent trust in traditional healthcare providers. However, the varying willingness to share with non-traditional stakeholders suggests that while some consumers are open to sharing, others remain hesitant and selective. Data privacy policies and practices need to recognize and respond to multifaceted and stakeholder-specific attitudes.

Conclusion
LCA reveals significant heterogeneity in health data-sharing attitudes among U.S. consumers, providing insights to inform the development of data privacy policies.
Wildland Firefighters Suffer Increasing Risk of Job-Related Death
Authors: Glover Kelsey , Mittal Rohit , Kahn Steven A 
Published: January 2025

Abstract
Wildland firefighting is a niche specialization in the fire service - inherently dangerous with unique risks. Over the past decade, fatalities amongst all firefighters have decreased; however, wildland firefighter fatalities have increased. This subject has only been described in the grey literature, and a paucity of medical literature exists. The United States Fire Administration's online fatality database was queried for on duty mortality between 1990 and 2022. The year 2001 was excluded due to the 340 deaths that occurred on September 11th. Data collected included demographics, incident characteristics, and nature of fatality and was compared between the decades using a Fisher's exact test. From 1990-2000 to the decade of 2013-2022, there has been a significant increase in wildland fatalities, from 2% to 10% of total fatalities (p &lt; 0.00001). Despite the recent wave of 2023 wildfires across North America, the average annual number of wildfires has decreased 23% (from 79,829 to 61,377) between 1990-2000 and 2013-2022. Burn related fatalities have increased over time, from 9% of fatalities to 27% (p &lt; 0.01), while trauma related injuries decreased significantly between the second and third decade (p &lt;0.01). MI accounted for 16% of total fatalities, with no significant change over time. Although wildfires have become less common over the past decade, there was a 5-fold increase in wildland firefighter fatalities with burn related fatalities also increasing. Further investigation, including analysis of 2023 data, is required to augment development of health and safety measures for these heroes.
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity
Authors: Huard Arnaud , Fauteux-Daniel Sébastien , Goldstein Jérémie , Martin Praxedis , Jarlborg Matthias , Andries Julie , Caruso Assunta , Díaz-Barreiro Alejandro , Rodriguez Emiliana , Vaillant Laurie , Savvides Savvas N , Gabay Cem 
Published: January 2025

Abstract
Interleukin (IL)-18 is an immunoregulatory cytokine that acts as a potent inducer of T helper 1 and cytotoxic responses. IL-18 activity is regulated by its decoy receptor IL-18 binding protein (IL-18BP), which forms a high-affinity complex with IL-18 to block binding of the cognate receptors. A disbalance between IL-18 and IL-18BP associated with excessive IL-18 signaling can lead to systemic inflammation. Indeed, the severity of CpG-induced macrophage activation syndrome is exacerbated in IL-18BP knockout (KO) mice. On the contrary, targeting IL-18BP can have promising effects to enhance immune responses against pathogens and cancer. We generated monoclonal rabbit anti-mouse IL-18BP antibodies labeled from 441 to 450. All antibodies, except from antibody 443, captured mouse (m)IL-18BP when used in a sandwich enzyme-linked immunosorbent assay. Using an IL-18 bioassay, we showed that antibody 441 did not interfere with the regulatory effect of mIL-18BP, whereas all other antibodies displayed different levels of antagonism. Further experiments were performed using antibody 445 endowed with potent neutralizing activity and antibody 441. Despite binding to IL-18BP with the same affinity, antibody 445, but not antibody 441, was able to release IL-18 from preformed IL-18–IL-18BP complexes. Administration of antibody 445 significantly aggravated the severity of CpG-induced macrophage activation syndrome as compared with antibody 441. Additional experiments using naïve wild-type, IL-18BP KO, and IL-18 KO mice confirmed the specificity of the neutralizing effect of antibody 445 toward IL-18BP. Our studies led to the development of a monoclonal anti-IL-18BP antibody with neutralizing activity that results in the promotion of IL-18 activities.
Cancer risk in carriers of TP53 germline variants grouped into different functional categories
Authors: Müntnich Lucas John , Dutzmann Christina M , Großhennig Anika , Härter Valentina , Keymling Myriam , Mastronuzzi Angela , Montellier Emilie , Nees Juliane , Palmaers Natalie E , Penkert Judith , Pfister Stefan M , Ripperger Tim , Schott Sarah , Silchmüller Farina , Hainaut Pierre , Kratz Christian P 
Published: January 2025

Abstract
Li-Fraumeni syndrome is a cancer predisposition syndrome caused by pathogenic TP53 germline variants and associated with a high lifelong cancer risk. We analysed the German LFS registry that contains data on 304 individuals. Cancer phenotypes were correlated with variants grouped according to their ability to transactivate target genes in a yeast assay using a traditional (non-functional, partially-functional) and a novel (clusters A, B, C) classification of variants into different groups. Partially-functional and cluster B or C variants were enriched in patients not meeting clinical testing criteria. Time to first malignancy was longer in carriers of partially-functional variants (Hazard Ratio [HR] = 0.38; 95% CI, 0.22 to 0.66). Variants grouped within clusters B (HR = 0.45; 95% CI, 0.28 to 0.71) or C (HR = 0.34; 95% CI, 0.19 to 0.62) were associated with later cancer onset than NULL variants. These findings can be used to risk-stratify patients and inform care.
Addressing the widest answerable question: English “just” as a domain widening strategy
Authors: Deo Ashwini , Thomas William Carl 
Published: January 2025

Abstract
This paper offers a unified account of the English particle just that covers its exclusive, emphatic/intensifying, precisifying, unexplanatory, unelaborative, and counter-expectational uses. Drawing on an insight from another semantic domain, we claim that the chameleon-like behavior of just can be made sense of if we treat it as having a domain-widening function. The key proposal is as follows: the use of just indicates that the speaker is considering the widest set of alternative answers relevant at the context. The analysis relies on the notion of the optimal construal of an underspecified question, which makes use of a comparison between the inquisitivity of questions, modeled as the width of a question. The optimal construal of a question further depends on its answerability – i.e. whether the speaker considers a true answer to be accessible at the context (satisfying Quality) and whether the speaker considers addressing it to be relevant to discourse goals (satisfying Relevance). The diverse contextual effects of just that are observed arise from the interaction between the way in which the set of alternative answers to the underspecified question is construed and what is taken to be the speaker’s motivation for signaling that the widest answerable construal of the question is being addressed via the prejacent.
The role of religiosity and spirituality in coping with sickle cell disease clinical severity
Authors: Stewart Courtney A , Abdallah Khadijah E , Buscetta Ashley J , Galindo Corina , Ramirez Hasmin C , Williams David R , Bonham Vence L 
Published: January 2025

Abstract

Objectives
Religiosity and spirituality often play a role in managing chronic diseases. Sickle cell disease (SCD) is a genetic chronic disease associated with lifelong complications, but there is limited analysis of the potential impact of religiosity and spirituality on SCD. This study aims to analyze the association between constructs of religiosity and spirituality with health outcomes (disease severity, depression, and pain) in an SCD population (n = 275).

Methods
Data from the INSIGHTS Study (NCT02156102) were used for this analysis. The relationships between religious/spirituality measures (religious attendance, self-reported spirituality, religious saliency, coping, and support) and SCD outcomes (disease severity, depression, and pain scores) were analyzed through bivariate correlations and multivariable models. Models adjusted for different dimensions of religiosity and spirituality separately (Model 1) and all measures simultaneously (Model 2).

Results
In the bivariate analyses, we found a positive association between disease severity and spirituality (P &lt; .05) and an inverse relationship between positive religious coping and depression (P = .01). In Model 1, which adjusted for individual measures separately, there was an association between SCD severity and spirituality (β = 0.07, P &lt; .001) as well as with religious attendance (β = 0.02, P &lt; .01). However, in the models that simultaneously adjusted for all the measures (Model 2), religious attendance was no longer associated with SCD severity (β = 0.006, P &gt; .05), while the association with spirituality remained significant (β = 0.05, P &lt; .05).

Conclusions
The observed associations between spirituality and disease severity among patients with SCD suggest that individuals with severe disease may beneficially use spirituality to cope with complications. Future research should rigorously evaluate this hypothesis.
Molecular mechanisms affected by boron deficiency in root and shoot meristems of plants
Authors: Chu Liuyang , Schäfer Cay Christin , Matthes Michaela S 
Published: January 2025

Abstract
Boron deficiency is an abiotic stress that negatively impacts plant growth and yield worldwide. Boron deficiency primarily affects the development of plant meristems, groups of stem cells critical for all postembryonic tissue growth. The link between boron and meristem development was first established in 1923, when boron’s essentiality was discovered. It remains, however, unclear whether boron directly integrates into molecular meristem pathways. In addition to its stabilizing function in the primary cell wall, growing evidence suggests roles of boron in various molecular processes including phytohormone cascades. These indications help enhance a mechanistic understanding of why boron is crucial for proper meristem development. In this review we compile and discuss molecular pathways influenced by boron availability in Arabidopsis (Arabidopsis thaliana), maize (Zea mays), rice (Oryza sativa), and oilseed rape (Brassica napus) with a focus on the auxin-, ethylene-, and cytokinin-mediated hormone cascades. We particularly compare and contrast phenotypic and molecular adaptations of shoot and root meristems to boron deficiency and pinpoint tissue-specific differences.
How digital paywalls shape news coverage
Authors: Dhillon Paramveer S , Panda Anmol , Hemphill Libby 
Published: January 2025

Abstract
The internet has significantly transformed how news is produced, consumed, and distributed. As a result, the news industry has transitioned from ad-supported to subscription-based models regulated by digital paywalls. In the light of this disruption, it is crucial to investigate not only how news consumers adapt to this change but also how economic incentives shape content coverage. We analyzed the staggered adoption of digital paywalls by 17 regional US newspapers over 17 years in a difference-in-difference framework to examine the impact of paywall adoption on topical news content coverage. Our results reveal a small but significant decrease in local and soft news coverage, with varying effects across different urban contexts. Specifically, local news coverage experienced a more substantial decline in smaller cities (population&lt;500,000) and regions experiencing an influx of younger residents (age &lt; 40 years). Conversely, soft news coverage increased in areas with a younger demographic influx, indicating a strategic shift by newspapers to cater to digital-savvy audiences and adapt to changing consumption patterns. Our findings underscore the delicate balance between financial imperatives and editorial choices in the newspaper industry and highlight the need for ongoing research into the effects of digital monetization strategies on journalistic content creation, media plurality, and civic accountability.
Exclusionary bargaining behavior in 14 countries: Prevalence and predictors
Authors: Baranski Andrzej , Haas Nicholas 
Published: January 2025

Abstract
Primates are known to engage in exclusionary behavior, forming alliances to block a minority from accessing scarce resources. Humans are no exception, and examples of exclusionary behavior abound in political, business, and social settings. However, despite its socio-economic relevance, little is known about the prevalence and determinants of such behavior worldwide. Conducting an experimental game in which a group divides resources by majority rule, we document considerable global heterogeneity in exclusionary behavior. Whereas exclusion is modal in some countries, inclusive behavior is the norm in others. Despite significant cross-country variability, we nevertheless find that individual-level characteristics matter similarly across contexts. Men, individuals with a deliberative reasoning style, and ideologically right-leaning individuals, are consistently and substantially more exclusionary. Cross-country differences in the formation of exclusionary alliances correlate with an original Hierarchy Tolerance Index, derived from variables measuring cultural acceptance of power inequalities. Our findings carry important implications for decision-making bodies, as they indicate that the identity of decision-makers and the culture in which they are embedded can affect how equitably resources are divided.
One loop β functions for mirror noncommutative Euclidean Yukawa sector within electroweak- scale right handed neutrinos model
Authors: Bouteldja K A , Bouayed N , Kouadik S , Ighezou F-Z 
Published: January 2025

Abstract
In this paper, we derive the renormalization scale dependence of noncommutative mirror Yukawa couplings. To achieve this, we first formulate an Euclidean noncommutative version of the Yukawa sector within the electroweak-scale mirror right handed neutrinos model. Then, we calculate the noncommutative one loop β functions of Yukawa couplings for mirror fermions involved in this model, by taking advantage of the Slavnov Taylor identities for the universal mirror Yukawa couplings, and by using the noncommutative vulcanised scalar and spinor propagators that prevent the UV/IR mixing. This leads us to a system of six cubic coupled first order differential equations that depend only on the mirror Yukawa couplings and not on the noncommutative deformation and vulcanised parameters. We solve this system numerically for different initial conditions to get the evolution of the mirror Yukawa couplings in terms of the renormalization scale. Furthermore, we discuss the link to the commutative case and analyze the occurrence of the Landau pole for some specific sets of initial conditions.
Melons as Lemons: Asymmetric Information, Consumer Learning and Seller Reputation
Authors: Bai Jie 
Published: January 2025

Abstract
Quality provision is often low in many developing markets, and firms commonly lack a reputation for quality. This article examines this issue both theoretically and empirically in the context of retail watermelon markets in China. I first demonstrate the existence of significant asymmetric information on quality between sellers and buyers, as well as the absence of a quality premium at baseline. To explain this, I develop a theoretical model that highlights the role of consumer beliefs and costly signalling in influencing sellers’ reputation incentives. I then conduct an experiment by randomly introducing two signalling technologies into different markets: a cheap sticker label and a more expensive laser-cut label. Consistent with the theoretical predictions, the laser label induces sellers to offer higher quality, resulting in increased sales and profits, while the sticker label fails to achieve the same effect. Using the experimental variation, I estimate an empirical model of consumer learning to uncover the underlying evolution of beliefs. The results show that pessimistic beliefs under the sticker label can hinder reputation building, whereas the laser label enhances consumer learning and strengthens sellers’ reputation incentives.
Barriers and facilitators to sustaining a lupus patient decision aid in regular rheumatology outpatient care in the US
Authors: Blanchard Erin E , Hall Allyson G , Gore Ezra , Jami Parvaneh Yaghoubi , Karabukayeva Aizhan , Hearld Larry R , Gontarz Shelby , Singh Jasvinder A 
Published: January 2025

Abstract

Objective
This study investigates the barriers and facilitators to sustaining a decision aid (DA) tool for patients with systemic lupus erythematosus (SLE) in routine rheumatology outpatient care across the U.S. The DA was initially developed for assisting Patients with SLE in making informed medication choices by providing personalized information on their treatment process.

Methods
We conducted semi-structured interviews with clinicians, administrators, and information technology (IT) professionals from 15 geographically diverse rheumatology clinics that participated in a large-scale DA implementation trial. Interviews were transcribed and analyzed using NVivo, with thematic coding to identify key factors influencing DA sustainability.

Results
Analysis identified several facilitators, including the DA's user-friendly design and its effectiveness in simplifying complex medical information, aiding informed decision-making for Patients with SLE. Challenges included inconsistent staff knowledge about the DA, difficulties integrating the DA into clinical workflows, a lack of executive and physician champions, and a lack of structured training and communication strategies. Additionally, concerns were raised about the availability of staff support and the technological capabilities required to maintain the DA’s use.

Conclusion
To sustain the DA in clinical practice, there is a need for enhanced training programs, better workflow integration, in-clinic physician champions, and effective use of electronic medical records for DA dissemination. Addressing these areas can improve the DA's impact on patient education and decision-making, ensuring its continued use in routine care.
Urinary Chemistry in Healthy Cross-bred Pet Rabbits (Oryctolagus cuniculus) and Rabbits with Suspected Chronic Kidney Disease
Authors: Sze-Yu Yeh , Chi-Hsuan Sung , Pin-Chen Liu , Ching-Fen Wu , Tsai-Lu Lin , Tsung-Li Cheng , Chi-Chung Chou 
Published: January 2025

Abstract
Renal biomarkers for early detection of decreased kidney function have been extensively studied in dogs and cats, but there is limited research for pet rabbits. Specifically, studies on urinary indices for cross-bred rabbits are scarce. Therefore, this study aimed to assess the potential use of urinalysis in cross-bred pet rabbits. Urine samples from 30 healthy crossbred pet rabbits and 11 rabbits with suspected kidney disease (KD) from three clinics were collected. Reference intervals of urinary indices, including urinary protein, creatinine (uCRE), urinary protein-to-creatinine (UPC) ratio, gamma-glutamyl transferase (uGGT), and uGGT ratio, were established and compared to two published reference intervals (RIs). The results showed that healthy rabbits consistently had low urine protein levels and abnormal UPC ratios, compared to a published study involving only pure-bred rabbits. Rabbits with KD had higher urine protein levels and significantly higher UPC ratio (p&lt;0.001), with 63% having ratios greater than 0.4. Additionally, rabbits with KD showed significantly (p&lt;0.001) lower uCRE levels and urine specific gravity (USG) with elevated uGGT index (p&lt;0.05), compared to the healthy group. Significant differences (p&lt;0.05) were also observed in urine color, turbidity, pH, and positivity of the occult blood by dipstick. This study underscores potential breed-specific variations in urinary protein levels and UPC ratio, as well as highlights the diagnostic potential of USG, UPC ratio, and uGGT index in rabbits with KD. However, the presence of breed-specific variations and technical nuances in laboratory equipment necessitate careful interpretation of results. Therefore, further studies across larger and more diverse rabbit populations are crucial to validate the diagnostic performance of urinary indices in diagnosing KD in rabbits.
CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor
Authors: Kumar Rajendra , Mendonca Janet , Shetty Abhishek , Yang Yuhan , Owoyemi Olutosin , Wilson Lillian , Boyapati Kavya , Topiwala Deven , Thomas Naiju , Nguyen Huong , Luo Jun , Paller Channing J. , Denmeade Samuel R. , Carducci Michael A. , Kachhap Sushant K. 
Published: January 2025

AbstractAmong the known nuclear exportins, CRM1 is the most studied prototype. Dysregulation of CRM1 occurs in many cancers, hence, understanding the role of CRM1 in cancer can help in developing synergistic therapeutics. The study investigates how CRM1 affects prostate cancer growth and survival. It examines the role of CRM1 in regulating androgen receptor (AR) and DNA repair in prostate cancer. Our findings reveal that CRM1 influences AR mRNA and protein stability, leading to a loss of AR protein upon CRM1 inhibition. Furthermore, it highlights the involvement of HSP90 alpha, a known AR chaperone, in the CRM1‐dependent regulation of AR protein stability. The combination of CRM1 inhibition with an HSP90 inhibitor demonstrates potent effects on decreasing prostate cancer cell growth and survival. The study further explores the influence of CRM1 on DNA repair proteins and proposes a strategy of combining CRM1 inhibitors with DNA repair pathway inhibitors to decrease prostate cancer growth. Overall, the findings suggest that CRM1 plays a crucial role in prostate cancer growth, and a combination of inhibitors targeting CRM1 and DNA repair pathways could be a promising therapeutic strategy.