bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation
Authors: Uy Jessica P. , Gotlib Ian H. 
Published: December 2023

BackgroundExposure to adversity early in life (ELA) has been associated with elevated risk for depression during adolescence, particularly for females; the mechanisms underlying this association, however, are poorly understood. One potential mechanism linking ELA and sex differences in depressive symptoms is sleep disturbances, which increase during adolescence and are more common in females. Here, we examined whether sleep disturbances mediate the association between ELA and increases in depressive symptoms during adolescence and whether this mediation differs by sex.Methods224 (N = 132 females) youth were recruited at age 9–13 years and assessed every 2 years across three timepoints. At the first timepoint, we conducted extensive interviews about stressful events participants experienced; participants provided subjective severity ratings of events and we objectively scored the severity of each event. Self‐reported sleep disturbances and depressive symptoms were assessed at all timepoints. We conducted linear mixed models to estimate both initial levels and changes in sleep disturbances and depressive symptoms, and moderated mediation analyses to test whether initial levels and/or changes in sleep disturbances mediated the association of ELA (objective and subjective) with increases in depressive symptoms across adolescence and whether the mediations differed by sex.ResultsWhile higher initial levels and increases in sleep problems were uniquely associated with increases in depressive symptoms for males and females, they were related to ELA differently by sex. For females, greater ELA (both objectively and subjectively rated) was associated with higher initial levels of sleep problems, which in turn were associated with increases in depressive symptoms from early to late adolescence. In contrast, for males, ELA exposure was not associated with either initial levels of, or increases in, sleep problems.ConclusionsThese findings highlight the role of sleep disturbances during the transition to adolescence in mediating sex differences in the effects of ELA on depressive symptoms.
Safety and efficacy evaluation of botulinum toxin an injection by FITTER® microneedle to treat medial lower eyelid wrinkles
Authors: Fan Xing , Long Jie , Quan Xin , Yin Yue , Li Tong , Qiang Shuai , Liu Bin , Li Yang 
Published: December 2023

AbstractBackgroundTreatment for medial lower eyelid wrinkles is in great demand now. However, conventional injection of botulinum toxin A (BTX‐A) often leads to serious complications.AimsWe aim to evaluate the safety and efficacy of BTX‐A injection with microneedle to treat medial lower eyelid wrinkles.MethodsWe collected clinical data of 16 patients to treat dynamic wrinkles on the medial aspect of the lower eyelid. Adverse effects at each stage of the treatment were recorded. We used VISIA to compare the static and dynamic wrinkles of the medial lower eyelid before and after treatment. Furthermore, patients and physicians evaluated the wrinkles with Kappa scores.ResultsAll 16 patients completed the study. The objective evaluation indicator (the Ra variable given by VISIA) progressively and significantly decreased at 1 month and 3 months after treatment. The kappa scores given by patients and by surgeons were both significantly reduced after treatment. No adverse reactions, such as pouch prolapse, diplopia, and canthal tendon laxity, occurred at 1 week, 1 month, or 3 months after the treatment.ConclusionBTX‐A treatment of medial lower eyelid wrinkles with microneedle injection allows better control of the injection depth and reduces both the amount of BTX‐A needed and the incidence of complications while maintaining the natural dynamic expression.
The impact of nurses' experiences of hospital violence on resilience: A mediated moderation model
Authors: Zheng Zhihui , Zhan Shanshan , Xu Jiaxian , Lu Kangyuan , Wang Jie , Huang Bixia , Li Xiaohong , Chen Yubei , Ge Li 
Published: December 2023

AbstractAimsThis study aims to investigate the impact of nurses' experiences of hospital violence on resilience, the mediating effect of trust in patients and the moderating effect of organizational trust.BackgroundDespite belonging to the central part of health care worldwide and being the leading provider of medical services, nurses are often subjected to hospital violence, which affects their physical and mental well‐being. Trust is a high‐order mechanism that encourages positive thinking and personal and professional development. However, research into the impact of trust on resilience concerning nurses' experiences of hospital violence is limited.MethodsThe participants were 2331 nurses working in general hospitals in China. A cross‐sectional survey was conducted, and data were collected via questionnaires from July to October 2022 and analysed using SPSS 25.0 and SPSS PROCESS 3.3 macros. This study was prepared and reported according to the STROBE checklist.ResultsMean trust in patients was 48.00 ± 10.86 (12–60), mean organizational trust was 56.19 ± 8.90 (13–65) and mean resilience was 78.63 ± 19.26 (0–100). Nurses' experience of hospital violence had a direct negative effect on resilience (β = −.096, p = .871), a significant adverse effect on trust in patients (β = −3.022, p < .001) and a significant positive effect on trust in patients on resilience (β = 1.464, p < .001). Trusting patients played a mediating role. The significant moderating effect of organizational trust between experience of hospital violence and trust in patients was moderated by a mediating effect index of −0.1867 (95% CI = [−0.3408, −0.0345]).ConclusionsNurses' experience of hospital violence exerted a negative effect on resilience, trust in patients had a fully mediated effect and organizational trust had a significant moderating influence in the pathway from nurses' experience of hospital violence to patients' trust‐mediated resilience.Implications for Nursing and Health PolicyThis study highlights the impact of nurses' experiences of hospital violence on resilience and explores the importance of trust from the nurses' perspective. Measures taken by managers to provide nurses with a safe, trusting and positive work environment can be highly beneficial in enhancing nurse resilience.
Political connection heterogeneity and firm innovation: An investigation of privately controlled, publicly listed firms in China
Authors: Zhou Jieyu , Qian Cuili , Li Congshan 
Published: December 2023

AbstractThis study investigates the influence of ascribed and achieved political connections on corporate strategies of incremental versus radical innovation. The corporate political strategy literature maintains that while politically connected firms have access to resources controlled by the government, they also have an obligation to reciprocate for this access by fulfilling government expectations. We integrate an institutional perspective with the political strategy literature to develop the argument that ascribed political connections enhance incremental innovation because firms with these connections will tend to innovate just enough to meet government expectations. In contrast, firms with achieved political connections will tend to prefer radical innovation because these innovations help them to maintain their relationships with the government and expand their competitive advantage in the market. Furthermore, we propose that these effects depend on firms' innovation orientation, captured by the firms' technological capability, industry characteristics, and the innovation context of their geographical region. Our predictions are largely supported by analysis of a panel dataset of privately controlled, publicly listed Chinese firms during the period 2008 to 2018. Our findings reveal that the positive effect of ascribed political connections on incremental innovation is less salient when a firm has stronger technological capability, or when a firm operates in a high‐tech industry or a region with a strong innovative climate. Conversely, the positive influence of achieved political connections on radical innovation is stronger when a firm has stronger technological capability, or when a firm competes in a high‐tech industry or is located in a region with a strong innovative climate. We also discuss the important implications for firms and the government.
Recognize your audience: Stakeholders' coaptation work to improve political representation in innovation programs
Authors: Radaelli Giovanni , Currie Graeme 
Published: December 2023

AbstractManagers often exclude some stakeholders from innovation programs, believing they would be “dangerous” for the purpose and pace of new product/service development. The exclusion of “dangerous” stakeholders, however, has negative implications on innovation, as it prevents access to key knowledge and connections. Our study investigates how “dangerous” stakeholders can overturn their exclusion, and gain key decision‐making responsibilities. Theoretically, we import the “general theory of political representation” from Rehfeld (2006) to derive insight into agency of five actors: selection agents, strategic constellation and representatives (on the side of innovators), represented and “audience” (on the side of stakeholders). Empirically, we undertake a 4‐year longitudinal case study of a digital innovation program in an English public hospital. Our study highlighted that only an elite “audience” of clinical leads enacted a strategy of “coaptation work” to overturn their exclusion from the innovation program, and ascend to a role of selection agents. Through “coaptation work,” the clinical leads used their privileged access to clinical resources to first create fractures within the community of innovators, and then embed clinical stakeholders in key decision‐making roles to heal them. Our results challenge established “hub‐and‐spoke” interpretations of innovation programs, and emphasize the importance of political representation work to understand how stakeholders exert their influence.
Identification of reproductive sex‐biased gene expression in Asparagopsis taxiformis (lineage 6) gametophytes
Authors: Patwary Zubaida Parveen , Zhao Min , Paul Nicholas A. , Cummins Scott F. 
Published: December 2023

AbstractThe sub‐tropical red seaweed Asparagopsis taxiformis is of significant interest due to its ability to store halogenated compounds, including bromoform, which can mitigate methane production in ruminants. Significant scale‐up of aquaculture production of this seaweed is required; however, relatively little is known about the molecular mechanisms that control fundamental physiological processes, including the regulatory factors that determine sexual dimorphism in gametophytes. In this study, we used comparative RNA‐sequencing analysis between different morphological parts of mature male and female A. taxiformis (lineage 6) gametophytes that resulted in greater number of sex‐biased gene expression in tips (containing the reproductive structures for both sexes), compared with the somatic main axis and rhizomes. Further comparative RNA‐seq against immature tips was used to identify 62 reproductive sex‐biased genes (59 male‐biased, 3 female‐biased). Of the reproductive male‐biased genes, 46% had an unknown function, while others were predicted to be regulatory factors and enzymes involved in signaling. We found that bromoform content obtained from female samples (8.5 ± 1.0 mg·g−1 dry weight) was ~10% higher on average than that of male samples (6.5 ± 1.0 mg·g−1 dry weight), although no significant difference was observed (p > 0.05). There was also no significant difference in the marine bromoform biosynthesis locus gene expression. In summary, our comparative RNA‐sequencing analysis provides a first insight into the potential molecular factors relevant to gametogenesis and sexual differentiation in A. taxiformis, with potential benefits for identification of sex‐specific markers.
Heterogeneity‐oriented ensemble learning for rail monitoring based on vehicle‐body vibration
Authors: Zhuang Yong , Liu Rengkui , Tang Yuanjie 
Published: December 2023

AbstractIn this study, railway vehicle‐body vibration was applied to rail detection for convenient sensor deployment and cost‐effectiveness. However, the waveform is difficult to analyze due to damping and interference. Data‐driven methods can help concatenate multidimensional signals and complex rail‐surface irregularities but are impressionably uncertain. This study proposes a method in which a deep learning framework is coupled with heterogeneous factors at every link in its ensemble strategy. The instantiation, module foundation, and scenario description establish a concrete system for dealing with the dilemma that an insufficient database hinders feature extraction, causing unproductive capacity. The performance is quantitatively discussed by combining different levels of on‐site rail‐surface conditions, reaching prediction errors of 4.7% and 6.5% and classifier accuracies of 98.4% and 93.7% for irregularities and defect severities, respectively. This work describes a way to extend self‐learner applicability in industry and will facilitate new support for railway track management.
From informed to empowered consent
Authors: Hagopian Chelsea O. P. 
Published: December 2023

AbstractInformed consent is ethically incomplete and should be redefined as empowered consent. This essay challenges theoretical assumptions of the value of informed consent in light of substantial evidence of its failure in clinical practice and questions the continued emphasis on autonomy as the primary ethical justification for the practice of consent in health care. Human dignity—rather than autonomy—is advanced from a nursing ethics perspective as a preferred justification for consent practices in health care. The adequacy of an ethic of obligation (namely, principlism) as the dominant theoretical lens for recognising and responding to persistent problems in consent practices is also reconsidered. A feminist empowerment framework is adopted as an alternative ethical theory to principlism and is advanced as a more practical and complete lens for examining the concept and context of consent in health care. To accomplish this, the three leading conceptions of informed consent are overviewed, followed by a feminist critique to reveal practical problems with each of them. The need for a language change from informed to empowered consent is strongly considered. Implications for consent activities in clinical practice are reviewed with focused discussion on the need for greater role clarity for all involved in consent—beyond and inclusive of the patient‐physician dyad, as the practice and improvement of consent is necessarily a transdisciplinary endeavour. Specific concrete and practical recommendations for leveraging nursing expertise in this space are presented. Perhaps what is most needed in the discourse and practice of consent in health care is nursing.
Role of maternally expressed 8 small nucleolar RNA (MEG8) in osteogenic differentiation of periodontal ligament stem cells
Authors: Ye Cui , Ye Jun , Wu Haimiao , Zhang Fan , Liu Yuehua 
Published: December 2023

AbstractObjectivesPeriodontal ligament stem cells (PDLSCs) are essential for the treatment of bone diseases because of its great potential to differentiate into osteoblasts. Remarkably, increasing long‐non‐coding RNAs (lncRNAs) have been reported to be involved in the osteogenic differentiation of PDLSCs. Maternally expressed 8, small nucleolar RNA host gene (MEG8) is implicated in multiple diseases. This study intended to unearth the potential role of MEG8 and unveil the mechanism in PDLSCs undergoing osteoblastic differentiation.Materials and MethodsMEG8 expression was measured by quantitative real‐time PCR (RT‐qPCR) during osteogenic differentiation of PDLSCs into bone cells. Functional assays were used to uncover the biological function of MEG8. Besides, RNA pulldown, RNA‐binding protein immunoprecipitation (RIP), and luciferase reporter assays were used to explore the molecular mechanism of MEG8.ResultsMEG8 was apparently overexpressed in osteogenically differentiated PDLSCs. Moreover, MEG8 deficiency suppressed the osteoblastic differentiation of PDLSCs. Furthermore, MEG8 modulated the expression of transcription factor 4 (TCF4) by scavenging microRNA‐495‐3p (miR‐495‐3p) and microRNA‐485‐3p (miR‐485‐3p) through the competing endogenous RNA (ceRNA) mechanism, further stimulating the Wnt/β‐catenin pathway.ConclusionMEG8 stimulates the capacity of PDLSCs for osteogenic differentiation through a ceRNA mode.
Psychometric properties of a Turkish version of the social activities scale for community‐dwelling older people requiring support
Authors: Tastan Sevinc , Bebis Hatice 
Published: December 2023

AbstractBackgroundSocial activities decelerate the deterioration of mental capacity in older people and improve their physical and psychosocial health. Valid and reliable measurement tools are needed to determine the social activity status of older people and plan health services to protect their mental health.ObjectiveThis study aimed to adapt the Social Activities Scale for Community‐Dwelling Older People Requiring Support (SASOS) into Turkish.MethodsThis methodological study was conducted in Northern Cyprus between January and June 2022. Convenience sampling was used to recruit 155 community‐dwelling older people who needed support. Expert opinion, item‐content validity index, and scale‐content validity index were used to evaluate content validity. Internal consistency and test–retest reliability tests were used to evaluate reliability. Exploratory factor analysis was used to evaluate construct validity. The Loneliness Scale for Elderly was used to evaluate concurrent validity.ResultsThe Cronbach's alpha of SASOS was 0.90. Additionally, correlation coefficients of all items ranged between 0.61 and 0.79. Exploratory factor analysis revealed a three‐factor structure. ‘Interactions with friends and neighbors’ was the factor that explained the highest variance (46%). There was a negative, weak, and statistically significant relationship between the scores obtained from the social loneliness subscale of LSE and all three subscales of SASOS.ConclusionsThe Turkish version of SASOS is a valid, reliable instrument to evaluate social activities in community‐dwelling older people who needed support.Implications for practiceThe SASOS has been identified as a valuable measure for assessing the social support needs of older individuals. It serves as a guide for both planning and evaluating interventions to enhance their health.
Plant responses to temperature stress modulated by microRNAs
Authors: Islam Waqar , Adnan Muhammad , Alomran Maryam M. , Qasim Muhammad , Waheed Abdul , Alshaharni Mohammed O. , Zeng Fanjiang 
Published: December 2023

AbstractDue to the increasing impact of worldwide environmental changes, temperature stress has become a major factor resulting in crop yield losses. The discovery of temperature‐stress‐responsive protein‐coding genes has made significant progress in understanding plants' complex stress response systems involving microRNAs (miRNAs). The miRNAs are triggered by heat or cold, thus confirming their significant functional role in cold or heat tolerance. Such dependable recommendations significantly broaden our understanding of the regulatory role of miRNAs in plant stress responses. This article presents novel perspectives on the substantial roles of plant miRNAs in responding to and acclimatizing to heat and cold stress. It comprehensively elaborates on miRNAs responsive to temperature stress, their regulatory mechanisms, and their targeted functions in plants. Additionally, the article investigates how miRNAs contribute to safeguarding plant reproductive tissues, mitigating damage caused by reactive oxygen species, modulating heat shock proteins, transcription factors, and phytohormones in the context of temperature stress. The conclusion outlines potential avenues for future research, highlighting the utilization of miRNAs and their regulatory functions to develop economically vital crops with enhanced tolerance to temperature stress, thereby ensuring future food security.
Intron retention via alternative splicing affects the thermotolerance regulation of ZmHsf17
Authors: Zhang Huaning , Meng Xiangzhao , Li Ran , Ma Zhenyu , Liu Ran , Liu Zihui , Duan Shuonan , Zhang Wenying , Li Guoliang , Guo Xiulin 
Published: December 2023

AbstractHeat shock transcription factor (Hsf) plays a pivotal role in promoting rapid heat‐induced transcriptional reprogramming in plants. The thermotolerance regulatory function of Hsfs is influenced by their own alternative splicing. In this study, we found that ZmHsf17‐II, an intron retention isoform of subclass A2 gene ZmHsf17 of maize (Zea mays), accumulated in large amounts as a result of severe or sustained heat stress. It was confirmed by expression and purification that ZmHsf17‐II encodes a small truncated peptide with 115 amino acids. ZmHsf17‐II was found to be located in the nucleus and have no transcriptional activity. Overexpressing ZmHsf17‐I in Arabidopsis could enhance plants' thermotolerance, while overexpressing ZmHsf17‐II does not. Based on the results of molecular docking, Y2H and split LUC experiments, we found that ZmHsf17‐II could bind to DBD region of ZmHsf17‐I through the hydrogen bond interaction between the truncated DBD of ZmHsf17‐II and three amino acid residues (Arg105, Thr109 and Lys142) of ZmHsf17‐I DBD region. Further experiments showed that ZmHsf17‐I could bind to its own promoter and exhibited transcriptional activation activity, while ZmHsf17‐I interaction with ZmHsf17‐II, transcriptional activation activity was interfered. Those findings indicate that ZmHsf17 can negatively regulate its own transcription by producing more intron retention isoforms via alternative splicing under heat stress.