bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foreign labor and audit quality: Evidence from newly hired H‐1B visa holders
Authors: Frost Tracie , Jing Jiao , Shang Longfei , Su Lixin (Nancy) 
Published: January 2024

AbstractForeign workers have been an important part of the labor force in public accounting firms over the past two decades. In this paper, we investigate whether and why foreign workers influence audit quality. We find that audit offices with more newly hired foreign labor have a lower mean absolute value of discretionary accruals and a smaller rate of restatements for their clients. The effect is more pronounced for audit offices that face more resource constraints or require greater foreign expertise. The results of improved audit quality are robust to alternative measures of immigrant intensity and audit quality, alternative samples, and using different ways to address endogeneity concerns. Overall, our paper contributes to the literature by showing the impact of foreign labor in the auditing profession and provides public policy implications for the recent H‐1B visa debate.
Renal function after ductus arteriosus transcatheter closure with or without angiography in very preterm infants
Authors: Lembo Chiara , Méot Mathilde , Mellul Kelly , Aryafar Annahita , Szézépanski Isabelle , Iacobelli Silvia , Kermorvant‐Duchemin Elsa , Bonnet Damien , Malekzadeh‐Milani Sophie , Lapillonne Alexandre 
Published: January 2024

AbstractAimTranscatheter closure of the patent ductus arteriosus (TCPDA) is increasingly used in preterm infants as an alternative to surgical ligation. However, clinically ill preterm infants are at risk of contrast nephropathy due to the angiography contrast agents used during the procedure.MethodsWe performed a single‐centre before‐and‐after comparative study in VLBW infants to compare the kinetics of serum creatinine during the first 4 days after TCPDA with or without angiography.Results69 patients were included and divided into two groups: TCPDA with (contrast+; n = 37) and without (contrast−, n = 32) use of contrast agent. The median dose [range] of contrast agent was 1.0 mL/kg [0.6–2.4 mL/kg]. The change in serum creatinine level between day 2 to 4 after TCPCA and baseline decreased in the contrast‐ group (−17% [−46%; 18%]), while it increased in the contrast+ group (7% [−24%; 202%] p = 0.002). Comparison of blood urea levels between groups showed similar significant differences. The change in serum creatinine between day 2 to 4 and baseline was significantly correlated with the dose of contrast agent (r2 = 0.682; p < 0.001).ConclusionThe use of contrast agents during TCPDA can potentially harm the renal function of very preterm infants. Therefore, we advise minimising or avoiding the use of contrast agents.
Drivers of species composition in arable‐weed communities of the Austrian–Hungarian borderland region: What is the role of the country?
Authors: Pinke Gyula , Vér András , Réder Krisztina , Koltai Gábor , Schlögl Gerhard , Bede‐Fazekas Ákos , Czúcz Bálint , Botta‐Dukát Zoltán 
Published: January 2024

AbstractQuestionsDue to their high ecological and agronomical variability, borderland regions offer an excellent opportunity to study assembly patterns. In this study we compared the influence of various factors on summer annual weed communities consisting of both native and introduced species.LocationThe borderland region of Austria and Hungary.MethodsWe assessed the abundance of weed species in 300 fields of six summer annual crops, and collected information on 26 background variables for each plot. We applied redundancy analysis (RDA) to estimate multivariate species responses and variation partitioning to compare the relative importance of three groups of variables (environmental variables, management variables, and country as a singleton group), and we also checked for statistical association between country and the predictors of the other two groups.ResultsThe full RDA model explained 22.02% of the variance in weed species composition. Variation partitioning showed that environment and management had similarly high (~8%) influence on weeds, while country had a modest yet substantial (~1%) effect, and there was relatively little overlap between the variance attributable to the three groups. Comparing the individual variables, country ranked third (after preceding crop, and actual crop). The effects of 15 further variables were also significant, including seven management, and seven environmental variables, as well as the location of the sampling plots within the fields. Comparisons between the countries showed that farming type, preceding crops, tillage system, tillage depth and field size were significantly different between the countries.ConclusionsCountry exhibited a small but significant influence on weed community composition, which could not be explained with easily accessible management and environmental variables. This suggests that the distinct historical agronomical background of the two countries, possibly involving some legacies of the former Iron Curtain period, still has an impact on the weed species composition of arable fields.
Platycodin D ameliorates ammonia‐induced pulmonary fibrosis by repressing TGF‐β1‐mediated extracellular matrix remodeling
Authors: Lian Wenqi , Ge Shihao , Pang Quanhai 
Published: January 2024

AbstractAmmonia can induce pulmonary fibrosis in humans and animals. Platycodin D (PLD) possesses various bioactive activities including anti‐fibrotic properties. In this study, we aimed to explore the activity and mechanism of PLD in pulmonary fibrosis induced by ammonia. The mouse model of ammonia‐induced lung fibrosis was established, and the role of PLD was assessed by H&E and Masson's trichrome staining. The differentially expressed genes (DEGs) were identified by RNA‐seq and subjected to GO and KEGG pathway analyses. BEAS‐2B cells were treated with NH4Cl alone or along with PLD. Results showed that PLD attenuated ammonia‐induced pulmonary inflammation and fibrosis in vivo. The extracellular matrix (ECM)‐receptor interaction pathway was predicted as a prominent pathway underlying the anti‐fibrotic function of PLD. In ammonia‐induced mouse models and NH4Cl‐treated BEAS‐2B cells, PLD could repress the activation of the TGF‐β1 pathway. By incubating lung fibroblast HFL1 cells with the conditioned medium of BEAS‐2B cells treated with NH4Cl alone or along with PLD, PLD was confirmed to attenuate NH4Cl‐induced ECM deposition in HFL1 cells. Our findings demonstrate that PLD exerts a protective function in ammonia‐induced pulmonary fibrosis by repressing TGF‐β1‐mediated ECM remodeling, suggesting the potential therapeutic value of PLD in this disease.
Event assigning based on hierarchical features and enhanced association for Chinese mayor's hotline
Authors: Chen Gang , Cheng Xiaomin , Chen Jianpeng , She Xiangrong , Qin JiaQi , Chen Jian 
Published: January 2024

AbstractNowadays, manual event assignment for Chinese mayor's hotline is still a problem of low efficiency. In this paper, we propose a computer‐aided event assignment method based on hierarchical features and enhanced association. First, hierarchical features of hotline events are extracted to obtain event encoding vectors. Second, the fine‐tuned RoBERTa2RoBERTa model is used to encode the “sanding” responsibility texts of Chinese local departments. Third, an association enhanced attention (AEA) mechanism is proposed to capture the correlation information of the “event‐sanding” splicing vectors for the sake of obtaining matching results of “event‐sanding,” and the matching results are input into the classifier. Finally, the assignment department for is obtained by a department selection module. Experimental results show that our method can achieve better performance compared with several baseline methods on HEAD (a dataset we construct independently). The ablation experiments also demonstrate the validity of each key module in our method.
Efficacy of plant products in controlling disease vector mosquitoes, a review
Authors: Hillary V. Edwin , Ceasar S. Antony , Ignacimuthu S. 
Published: January 2024

AbstractMosquitoes pose a severe threat to the environment as vectors of numerous harmful diseases affecting humans and animals. Mosquitoes transmit pathogens that cause dengue, chikungunya, malaria, zika, yellow fever, Japanese encephalitis, and filariasis. Today's mosquito control strategies heavily rely on the use of chemical insecticides such as N,N‐diethyl‐meta‐toluamide (DEET), N,N‐diethyl mandelic acid amide (DEM), and dimethyl phthalate (DMP). However, the widespread use of chemical insecticides has resulted in pollution, bio‐magnification, and other health and environmental issues. It has also become ineffective because of the mosquitoes' aptitude to develop resistance, emphasizing the urgent need for safe, effective, and long‐lasting strategies. An alternative and promising approach to circumventing these obstacles involves the implementation of insecticides made from natural compounds found in plants. Therefore, the scientific community has shifted its focus towards plant‐based phytochemicals, oils, and extracts, as these are eco‐friendly, safe, and cost‐effective alternatives to conventional chemical insecticides. This review aims to provide details on current advances in plant‐based products (plant compounds, extracts, and essential oils), which are used to control all the life cycle stages (egg, larva, pupa, and adult) of the mosquito generaAedes,Anopheles, andCulex. Hopefully, this review will pave the way to devise control strategies against these challenging pests.
Association between several immune response‐related genes and the effectiveness of biological treatments in patients with moderate‐to‐severe psoriasis
Authors: Loras Alba , Gil‐Barrachina Marta , Hernando Barbara , Perez‐Pastor Gemma , Martinez‐Domenech Alvaro , Mahiques Laura , Pitarch Gerard , Valcuende‐Cavero Francisca , Ballester‐Sanchez Rosa , Marques‐Torrejon Maria Angeles , Martinez‐Cadenas Conrado 
Published: January 2024

AbstractBiological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30–50% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. Pharmacogenetic studies have identified several single nucleotide polymorphisms (SNPs) as possible predictive and prognostic biomarkers for psoriasis treatment response. The objective of this study was to determine the link between several SNPs and the clinical response to biological therapies in patients with moderate–severe psoriasis. A set of 21 SNPs related to psoriasis and/or other immunological diseases were selected and analysed from salivary samples of patients (n = 88). Treatment effectiveness and patient improvement was assessed clinically through Relative Psoriasis Area and Severity Index (PASI), also called ‘PASI response’, as well as absolute PASI. Associations between SNPs and PASI factors were assessed at 3 and 12 months for every treatment category of IL‐17, IL‐23, IL‐12&23 and TNF‐α inhibitors. Multivariate correlation analysis and Fisher's exact test were used to analyse the relationship between SNPs and therapy outcomes. Several SNPs located in the TLR2, TLR5, TIRAP, HLA‐C, IL12B, SLC12A8, TNFAIP3 and PGLYRP4 genes demonstrated association with increased short and long‐term therapy‐effectiveness rates. Most patients achieved values of PASI response ≥75 or absolute PASI<1, regardless of the biological treatment administered. In conclusion, we demonstrate a relationship between different SNPs and both short‐ and especially long‐term effectiveness of biological treatment in terms of PASI. These polymorphisms may be used as predictive markers of treatment response in patients with moderate‐to‐severe psoriasis, providing personalized treatment.
Judicial intelligent assistant system: Extracting events from Chinese divorce cases to detect disputes for the judge
Authors: Zhang Yuan , Li Chuanyi , Sheng Yu , Ge Jidong , Luo Bin 
Published: January 2024

AbstractIn the formal procedure of Chinese civil cases, the textual materials provided by different parties describe the development process of the cases. It is a difficult but necessary task to extract the key information for the cases from these textual materials and to clarify the dispute focus of related parties. Currently, officers read the materials manually and use methods, such as keyword searching and regular matching, to get the target information. These approaches are time‐consuming and heavily depend on prior knowledge and the carefulness of the officers. To assist the officers in enhancing working efficiency and accuracy, we conduct a case study of detecting disputes from Chinese divorce cases based on proposing a Two‐Round‐Labeling (TRL) event extracting technique in this article. We implement the Judicial Intelligent Assistant (JIA) system according to the proposed approach to (1) automatically extract focus events from divorce case materials, (2) align events by identifying co‐reference among them, and (3) detect conflicts among events brought by the plaintiff and the defendant. With the JIA system, it is convenient for judges to determine the disputed issues in Chinese divorce cases. Experimental results demonstrate that the proposed approach and system can obtain the focus of Chinese divorce cases and detect conflicts more effectively and efficiently compared with the existing method.
Multi‐failure psoriasis patients: characterization of the patients and response to biological therapy in a multicenter Italian cohort
Authors: Viola Riccardo , Mastorino Luca , Megna Matteo , Damiani Giovanni , Gisondi Paolo , Argenziano Giuseppe , Peris Ketty , Prignano Francesca , Burlando Martina , Conti Andrea , Loconsole Francesco , Malagoli Piergiorgio , Zalaudek Iris , Cacciapuoti Sara , Bellinato Francesco , Balato Anna , De Simone Clara , Chersi Karin , Ortoncelli Michela , Quaglino Pietro , Dapavo Paolo , Ribero Simone 
Published: January 2024

AbstractIntroductionPatients with psoriasis who have failed multiple biologic drugs have been defined as “multi‐failure,” although there are no clear data on the characteristics, comorbidities, and best treatment strategies for this population. Nowadays, given the next generation and the number of biologics available, patients are considered multi‐failure when ≥4 biologics fail to achieve a good response.MethodsDemographic characteristics and efficacy of anti‐interleukin drugs in multi‐failure patients were compared to a cohort of general psoriatic patients treated with IL‐23 or IL‐17 inhibitors.ResultsIn total 97 multi‐failure patients (≥4 lines of biologics) were compared with 1,057 patients in the general cohort. The current drugs in the multi‐failure group were risankizumab (34), ixekizumab (23), guselkumab (21), brodalumab (7), tildrakizumab (5), ustekinumab (4), secukinumab (2), and certolizumab pegol (1). A significant difference was found in the multi‐failure cohort for age of psoriasis onset (mean 29.7 vs. 35.1, P < 0.001), concurrent psoriatic arthritis (45.4 vs. 26.9%, P < 0.001), diabetes mellitus (30.9 vs. 10.9%, P < 0.001), and cardiovascular comorbidity (54.6 vs. 39.8%, P = 0.005). In multi‐failure patients, current biological therapy showed a good initial response (PASI 90 and 100 of 41.24 and 27.84%, respectively, at 16 weeks); the response tended to decline after 40 weeks. Anti‐IL‐17 agents showed clinical superiority over IL‐23 agents in terms of achieving PASI90 at 28 weeks (P < 0.001) and 40 weeks (P = 0.007), after which they reached a plateau. In contrast, IL‐23 agents showed a slower but progressive improvement that was maintained for up to 52 weeks. A similar trend was also seen for PASI100 (28 weeks P = 0.032; 40 weeks P = 0.121).ConclusionsThe multi‐failure patient is characterized by many comorbidities and longstanding inflammatory disease that frequently precedes the introduction of systemic biologic therapy. Further studies are needed to identify more specific criteria that could be applied as a guideline by clinicians.
Clinicopathologic features of relapsed CD19(−) B‐ALL in CD19‐targeted immunotherapy: Biological insights into relapse and LILRB1 as a novel B‐cell marker for CD19(−) B lymphoblasts
Authors: Chen Dong , Fuda Franklin , Rosado Flavia , Saumell Sílvia , John Samuel , Chen Mingyi , Koduru Prasad , Chen Weina 
Published: January 2024

AbstractIntroductionThe mechanism of relapsed CD19(−) B‐ALL after anti‐CD19 immunotherapy (Kymriah [CART‐19] and blinatumomab) is under active investigation. Our study aims to assess LILRB1 as a novel B‐cell marker for detecting CD19(−) B‐lymphoblasts and to analyze the clinicopathologic/genetic features of such disease to provide biological insight into relapse.MethodsSix patients (3 males/3 females, median age of 14 years) with relapsed CD19(−) B‐ALL were analyzed for cytogenetic/genetic profile and immunophenotype.ResultsCD19(−) B‐ALL emerged after an interval of 5.8 months following anti‐CD19 therapy. Five of six patients had B‐cell aplasia, indicative of a persistent effect of CART or blinatumomab at relapse. Importantly, LILRB1 was variably expressed on CD19(−) and CD19(+) B lymphoblasts, strong on CD34(+) lymphoblasts and dim/partial on CD34(−) lymphoblasts. Three of six patients with paired B‐ALL samples (pre‐ and post‐anti‐CD19 therapy) carried complex and different cytogenetic abnormalities, either as completely different or sharing a subset of cytogenetic abnormalities.ConclusionLILRB1 can be used as a novel B‐cell marker to identify CD19(−) B lymphoblasts. The emergence of CD19(−) B‐ALL appears to be associated with complex cytogenetic evolutions. The mechanism of CD19(−) B‐ALL relapse under anti‐CD19 immune pressure remains to be explored by comprehensive molecular studies.
Enhanced compressive strength of porous alumina realized by synergy between La‐doping and two‐step sintering
Authors: Kim Sung‐Hyun , Woo Jong‐Won , Hong Sang‐Min , Kim Jong‐Won , Moon Kyoung‐Seok , Yang Dong‐Yeol , Jeon Sang‐Chae 
Published: January 2024

AbstractSintering phenomena, densification, and grain growth are crucial for proper control of the microstructure for good mechanical strength. Here, materials and processing parameters, the addition of La2O3, and two‐step sintering (TSS) were combined to lead to higher strength in the porous alumina prepared by freeze‐casting. Based on grain growth and densification behaviors with the La2O3 doping, a beneficial thermal profile was designed for the TSS. As a result, higher relative density levels and smaller grain size were obtained compared with the results with conventional sintering (CS): 38.56% and 0.82 µm at 1500°C by CS; 40.78% and 1.78 µm at 1600°C by CS; 41.43% and 0.87 µm by TSS. The microstructural benefits provided ∼1.4 times higher compressive strength (5.46 MPa) from TSS than from the CS sample (3.92 MPa), highlighting the synergetic effect of La2O3 doping and the TSS strategy.
3D‐printed green and low‐cost porous g‐C3N4/geopolymer components for the removal of methylene blue from wastewater
Authors: Liu Xuehui , Ma Siqi , Yang Hualong , He Peigang , Duan Xiaoming , Jia Dechang , Colombo Paolo , Zhou Yu 
Published: January 2024

AbstractIn this study, we report that geopolymer materials containing different amounts of graphitic carbon nitride (g‐C3N4) (C3N4/GP) can remove methylene blue (MB) using the synergistic effects of adsorption and photodegradation. A geopolymer containing 3 wt% g‐C3N4 (3 wt%C3N4/GP) had the best MB removal efficiency of 94.62% within 60 min, under visible light. The results showed that geopolymers can act as carriers for g‐C3N4, and the relative amount of adsorbent and photocatalyst influences the removal of MB. 3 wt%C3N4/GP was also used for additive manufacturing by using direct ink writing technology. In order to improve the efficiency of MB removal, a pore‐forming agent (K12) was added in the synthesis process to prepare three‐dimensional‐printed porous C3N4/GP. The results showed that the porous C3N4/GP was effective in removing MB. This work provides a simple strategy for preparing efficient and green materials for removing organic pollutants.
Microwave‐modified xanthan gum: Alterations in steady and dynamic rheological behaviors
Authors: Kurt Abdullah , Ozturk Eylul , Ozmen Duygu , Yildirim‐Yalcin Meral , Arici Muhammet , Toker Omer Said 
Published: January 2024

AbstractIn this study, microwave modification of xanthan gum (XG) powder under various power and time settings was aimed at achieving diversity for different applications requiring different flow behaviors. Microwave treatment for 6 min at various powers showed no noticeable effect on the properties of XG. The apparent viscosity, consistency coefficient and viscoelastic properties (G′–G″) increased as powders were subjected to microwave treatment for up to 8 min and the highest increase was observed in XGs with 720 W application. The increasing power to 1200 W resulted in a decrease in consistency at 8 min. At all levels of power, a prolonged microwave treatment (10 min) resulted in the degradation of the molecules, leading to a decrease in the mentioned rheological properties of XG. The values for intercepts (K′ and K″) began to increase at 960 W‐6 min, with the largest increase occurring at 720 W‐8 min. Fourier transform infrared (FTIR) analysis revealed that the primary structure and repeated units were not negatively impacted by the use of microwave treatment. Therefore, with adjustable modification, microwaves may be employed to produce xanthan gum with a high economic value that is suitable for a variety of applications, while maintaining the gum's color properties.Practical applicationsOur research demonstrated that the use of microwave technology as a non‐thermal physical process to modify xanthan gum powder without dissolving it in water is a highly effective technique. This approach enables the flow characteristics of xanthan gum to be conveniently modified, regardless of its concentration, and increases its economic value by diversifying its techno‐functional properties. The increase in apparent viscosity and viscoelastic properties by increasing the interaction of polymer molecules or the adaptation of xanthan gum to different purposes by polymer degradation can be adjusted depending on the power and time of the microwave.
The Effect of Nonstress Device Noise Level on Stress Parameters in Primigravid Women: A Randomized Controlled Trial
Authors: Ayşenur Turan , Nuran Gençtürk , Cihan Kaya , Huri Bulut 
Published: January 2024

IntroductionThis study evaluated the effect of the noise level of the nonstress test (NST) device on stress parameters in primigravid women.MethodsA total of 44 pregnant women participated in a randomized clinical trial between February and October, 2021. The participants were divided randomly into 4 equal groups using an automated web‐based randomization system and ensuring allocation concealment: the control group (NST device volume turned off), intervention group I (1‐35 dB(A)), intervention group II (36‐60 dB(A)), and intervention group III (61 dB(A) and above). A data collection form was used to record personal information and stress parameters. Stress parameters (blood pressure, heart rate, oxygen saturation [SpO2], blood glucose, salivary cortisol, and salivary adrenocorticotropic hormone [ACTH]) levels were measured pretest (0‐2 minutes before NST starts), midtest (at 10 minutes of the NST), and posttest (within 0‐2 minutes after NST was finished). The study was registered at ClinicalTrials.gov (identifier: NCT05488704).ResultsNST sound levels above 35 dB(A) increased the average cortisol and ACTH levels in the posttest. NST sound levels were positively correlated with posttest cortisol (r = .448) and posttest glucose (r = .302). There was interaction effect on heart rate, glucose, and cortisol level by time, indicating that the intervention groups experienced a significant acceleration in heart rate, glucose, and cortisol level after a noise intervention compared with the control group.DiscussionMidwives should continue applying NST below 36 dB(A), considering the factors that may induce stress during the NST process.