bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARATIVE ASSESSMENT OF CLINICAL AND TECHNOLOGICAL PROPERTIES OF ASHLESS ACRYLIC PLASTICS
Authors: Bilobrov R.V. 
Published: December 2023

The aim of this study was to conduct a comparative evaluation of the clinical and technological properties of the proposed domestic ashless acrylic plastic.
Materials and methods. In collaboration with colleagues from the accredited research laboratory of dental materials of the Stoma company in Kharkiv, Ukraine, we conducted a comprehensive comparative analysis of ashless cold-cured plastics. The study included the assessment of both clinical and technical characteristics, including structuring temperature, mixing time, curing time, consistency, and viscosity. o gather laboratory data, various dental materials were used: "Modeplast" (Stoma JSC, Ukraine), "Pi-Ku-Plast" (Bredent, Germany), "Cerin" (Spofa Dental, Czech Republic), and "Txowax" (Yeti Dental, Germany). We measured the properties on 125 samples (25 from each material) according to the method of use provided by the international standard ISO 10139-2018.
Results. The study has revealed that the Modeplast material, manufactured by Stoma, exhibits a lower structuring temperature, specifically 2.3°C lower than Pi-Ku-Plast (Bredent), 1.2°C lower than Cerin (Spofa Dental), and 0.7°C lower than Txowax (Yeti Dental). Furthermore, the mixing time for Modeplast was notably shorter, being 7.5 seconds faster than Pi-Ku-Plast (Bredent), 1.5 seconds faster than Cerin (Spofa Dental), and 5.2 seconds faster than Txowax (Yeti Dental). In terms of hardening, Modeplast demonstrated the highest level of hardening compared to materials from other manufacturers. The consistency of Modeplast was stronger and harder, 1.5 mm harder than Pi-Ku-Plast (Bredent) demonstrated, 3.3 mm harder than Cerin (Spofa Dental) had and 1.7 mm harder than Txowax (Yeti Dental) showed. In terms of viscosity, Modeplast met the ISO-10139 standards, although it was 1.8 kJ/cm² lower in viscosity than Pi-Ku-Plast (Bredent) and 1.1 kJ/cm² lower in viscosity than Cerin (Spofa Dental). However, it was 0.2 kJ/cm² more viscous than Txowax (Yeti Dental).
The kneading time for Modeplast was notably shorter, indicating higher efficiency in usage. Regarding the curing process, Modeplast exhibited superior performance, proving to be faster than other materials. The consistency of Modeplast was characterized by increased strength and hardness when compared to its counterparts. In the aspect of viscosity, Modeplast adhered to ISO-10139 standards and demonstrated satisfactory performance, albeit with some distinctions from other materials.
Conclusion. Thus, our studies has demonstrated that Modeplast possesses superior technical characteristics, making it a compelling factor in the selection of dental materials for various components.
Remodeling of soft tissue in the extremities during acute ischemia-reperfusion in the context of acute hemorrhage
Authors: Lutsyk V.I. , Selskyy P.R. 
Published: December 2023

Histological and morphometric investigation of the soft tissues of the femur in white rats was conducted following acute 2-hour limb ischemia induced by the application of a tourniquet under conditions of acute blood loss. Morphological changes in the soft tissues were examined two hours after the tourniquet application without reperfusion. Tissue examination was carried out at various intervals after the elimination of ischemia: in 2 hours, 1 day, 2 days, 7 days, and 14 days. The early postischemic period model was represented by groups of animals with reperfusion changes at 1 hour, 2 hours, and 1 day after the removal of the tourniquet, while the late postischemic period model comprised groups examined on the 7th day and the 14th day after the removal of the tourniquet.
Pathological lesions in muscle tissue were evident as edema, structural and integrity impairments in myocytes, and leukocyte infiltration of endo- and perimysium. The lesions of microcirculatory bed were manifested by microarchitectonic damage, stasis, diapedesis hemorrhages, and perivascular cell infiltrates. The most pronounced changes in soft tissues due to reperfusion-ischemic syndrome under acute blood loss conditions were observed on the first day. During this period, the average diameter of muscle fibers ((43.66±0.41) μm) exceeded the corresponding control group indicator ((40.63±0.24) μm) by 6.94% (P < 0.01). Subsequently, there was a gradual normalization of indicators, with the diameter on the 14th day ((40.83±0.36) μm) not significantly differing from the control (P > 0.05).
The revealed patterns can be used to develop new approaches and methods for the correction of structural and functional disorders of soft tissues in lower extremities by different types of acute ischemic trauma under conditions of acute blood loss.
THE EFFECT OF CRONIC ISOLATED ADMINISTRATION OF CADMIUM CHLORIDE ON THE MORPHOLOGICAL STRUCTURES IN THE WALLS OF SMALL INTESTINE OF PREGNANT FEMALE RATS
Authors: Shatorna V.F. , Tymchuk K.M. 
Published: December 2023

In recent years, the anthropopolitical environmental polluntion with heavy metals has become one of the main threats to living organisms, including humans, and economic and technological progress is increasingly resulting in the disruption of natural ecosystems. Heavy metals include more than forty chemical elements of the periodic table, including chromium, cadmium, manganese, mercury, iron, cobalt, nickel, and others. They are often used in industry and are part of herbicides, insecticides, and medicines. In excessive quantities, they can change the structure of proteins, negatively affect metabolism, lead to cellular mutations, disrupt the structure and permeability of cell membranes, and cause malfunctioning of internal organs. Today, it is important to determine the impact of heavy metal compounds on the body in case of their constant (chronic) intake and accumulation in the body.
The purpose of this study was to determine morphological changes in the structure of the walls in the small intestine of rats subjected to the chronic isolated exposure to cadmium salts in a dose of 2.0 mg/kg (enteral administration).
The study involved 32 young female Wistar rats, with weights ranging from 180 to 300 g. Female rats with confirmed pregnancies were divided into the following groups: the first group served as the control, and the second group underwent isolated injection of cadmium chloride solution at a dose of 2.0 mg/kg.
The results of the experimental daily intragastric long-term administration of cadmium chloride showed morphological changes in the structure of the small intestine in rats. The analysis of the data obtained showed that exposure to cadmium chloride in a dose of 2.0 mg/kg leads to a significant thinning of the villi of the small intestine and mucous membrane compared to the control. When exposed to cadmium chloride in the specified dose, the number of goblet cells in the mucous membrane of the small intestine villi increased at both periods of the study, which indicates an increase in the protective function of the small intestinal mucosa against the action of a negative factor. Under the influence of cadmium, the narrowing of the outer and inner diameters of the crypt was also determined that is confirmed by the calculation of the index of the diameter of the small intestine crypt.
Regulatory and Legal Bases of Digitalising Book Monuments of Ukraine
Authors: Koleko Mykhailo 
Published: December 2023

The aim of the article is to analyze the laws of Ukraine, the resolutions of the Cabinet of Ministers of Ukraine, the Orders of the Ministry of Culture and Information Policy of Ukraine in the context of their defining the normative and legal bases of working with book monuments of Ukraine. The article studies the settlement of the issue of Ukrainian book heritage digitization as a tool for its preservation and popularization.
Research methods involve a combination of analysis and synthesis methods in their dialectical interaction, as well as methods of empirical and theoretical research, and system and structural analysis.
The scientific novelty of the study consists in highlighting the presence of legal grounds in the current regulatory and legal base of Ukraine for the implementation of the technology of digitalizing Ukrainian book monuments, and working out ways to bring the legal field of Ukraine closer to the EU standards in terms of rare books digitization.
Main conclusions. Book monuments of Ukraine are of great importance for the national identity formation. The demand for the formation of a stable Ukrainian identity has increased after the full-scale russian invasion of Ukraine in 2022. Under these conditions, the protection of the spiritual heritage of Ukraine has become a matter of national security, taking into account the fact that it is impossible to form a national identity without it. In conditions of the active formation of a digital society, the opportunities for preservation, study and presentation of cultural monuments in the modern cultural sphere grow rapidly. Digitization technology is an effective tool for preservation and protection of book monuments, opens the way to their unhindered promotion in modern information space. In this article, the importance of protecting book monuments of Ukraine through the digitization technology introduction in conditions of the russian-Ukrainian war is emphasized. It is established that the existing regulatory and legal bases ground the legitimate foundation for the book monuments digitization. The prospects for improving the legal sphere of Ukraine in terms of its approximation to the standards of the European Union are clarified.
Modern Fundraising in Libraries of Foreign Countries
Authors: Tsilyna Maryna 
Published: December 2023

The aim of the article іs to find out the specifics of fundraising in libraries of foreign countries, and determine prospects for further implementation of such activities in Ukraine.
Research methods combine a set of general scientific methods of studying problems. In the process of studying professional and profile literatureі and determining the theoretical basis of scientific research, the survey-analytical method was applied. With help of the systematic method, single foreign practices of library fundraising were analyzed. The use of the induction method made it possible to generalize the studied material and draw conclusions about the implementation of experience of other countries in Ukrainian library institutions. The scientific article is based on the principles of objectivity and integrity.
Scientific novelty consists in defining the main forms and means of modern fundraising interaction in the field of library activity.
Main conclusions. A significant role in fundraising cooperation in the library field is played by well-established ties in the sphere of international culture, as mutual support and fundraising financing strengthen the national base of any state in another country. Various events holding, such as conferences, seminars, concerts and meetings, as well as active involvement of social networks, creation of separate web pages on library websites, effectively contribute to charity. The EU provides many direct and indirect financial opportunities for the development of book collections on its territory. ESIF are the most important source of European indirect funding. In modern Ukraine, the domestic content of book collections is actively integrated into the European space, which, in particular, proves the fundraising activity of “Ukrainian book without borders” and “Librarians of Ukraine and Germany – together to Victory” projects.
We hope that the existing examples of international cooperation in the library industry serve as a model for the implementation of further similar projects on the domestic base, and, at the same time, for the popularization of Ukrainian books abroad. In general, international fundraising in library activities in modern world is a promising investment in future spirituality.
Linear Active Disturbance Rejection Lateral Controller for Unmanned All-Terrain Vehicle
Authors: Zeng Dequan , Hu Yiming , Jiang Zhiqiang , Feng Wanqiang 
Published: December 2023

Abstract: To address the disturbance of model uncertainty, a linear active disturbance rejection controller (LADRC) was designed for robust lateral control of unmanned all-terrain vehicle. In terms of relative motion of target node and current state, first-order lateral tracking model is established. According to the developed model, linear tracking differentiator (LTD), linear extended state observer (LESO) and linear state error feedback (LSEF) are designed in turn. LESO could observe the uncertainty of system and LSEF could compensate the uncertainty to make system robust. In order to verify the effectiveness, two typical scenarios, circle and double lane tracking, were designed for test. And the uncertainties of wheelbase and steering ratio were considered. Results illustrate that the designed LADRC can stably control the unmanned all-terrain vehicle tracking reference trajectory under both scenarios and has the advantages of small tracking error and small overshoot compared with the conventional pure tracking methods.
A Effect of Pregnancy Spacing and Gravida on The Incidence of Miscarriage
Authors: Sofia Norlaila , Prihatanti Nur Rochmah , Megawati Megawati 
Published: December 2023

Berdasarkan kajian determinan kematian ibu oleh Balitbang Kemenkes RI pada tahun 2012 bahwa 4,1% kematian ibu di Indonesia terjadi karena abortus. Faktor risiko terjadinya abortus yaitu faktor janin, maternal dan eksternal. Walaupun hanya berkontribusi 15% terhadap kejadian abortus, faktor maternal penting untuk diperhatikan khususnya dalam upaya pencegahan kejadian abortus. Salah satu penyumbang kasus abortus yang cukup tinggi di Kalimantan Selatan adalah Kabupaten Banjar. Tujuan penelitian yaitu menganalisis pengaruh faktor maternal jarak kehamilan dan gravida terhadap kejadian abortus. Rancangan penelitian ini observasional analitik dengan desain kasus kontrol. Kelompok kasus adalah semua ibu hamil yang mengalami abortus sebanyak 61 responden dan kelompok kontrol berjumlah 244 responden (1:4), penelitian dilaksanakan di wilayah kerja Puskesmas Astambul Kabupaten Banjar, Kalimantan Selatan pada tahun 2022. Data yang dikumpulkan adalah data sekunder, data dianalisis menggunakan uji chi square. Nilai P<0,05 dianggap bermakna secara statistik. Hasil penelitian menyatakan bahwa jarak kehamilan dan gravida tidak berpengaruh signifikan terhadap kejadian abortus (P>a), jarak kehamilan P = 0.405 dan gravida P = 0.341. Simpulan penelitian ini tidak terdapat pengaruh jarak kehamilan dan gravida terhadap kejadian abortus.
Kata Kunci: Abortus, Gravida, Jarak kehamilan
Pctx1 venom in the treatment of vasospasm due to experimental subarachnoidal hemorrhage
Authors: AKGÜN Mehmet Yigit , AKGÜL Mehmet Hüseyin 
Published: December 2023

Aims: We aimed to investigate the role of neuron damage in experimental animals following vasospasm, by increasing perfusion of neuronal tissue through vasodilation using the venom of PcTx1, and to determine its effectiveness in reducing neuron damage after vasospasm.
Methods: Thirty adult male Wistar albino rats weighing between 300 and 400 grams were used and divided into three groups: the Sham group (Group 1, n=10), to which no application was made; the SAH (control) group (Group 2, n=10), in which a double SAH model was created and 1 cc of saline was administered intraperitoneally; and the SAH+PcTx1 group (Group 3, n=10), in which a double SAH model was created and 1 cc/kg of PcTx1 venom was administered intraperitoneally daily. Basilar artery diameter and immunochemical measurements were performed histopathologically, and neurohistopathological findings were scored semiquantitatively in terms of vascular changes, neuron degeneration, gliosis, and bleeding criteria using a scale of 0 (none), 1 (mild), 2 (moderate), or 3 (severe). eNOS immunopositivity was also evaluated. The detection of apoptosis in the brain was performed by evaluating the effector enzyme caspase-3 immunoreactivity of the exogenous apoptosis pathway.
Results: The most severe vascular spasm and degeneration-necrosis of brain tissue gray matter neurons were seen in Group 2, whereas the vascular narrowing was less severe in Group 3. Brain parenchyma and neuron and neuroglial reactions were milder in Group 3. eNOS expression was detected at a higher level in Group 1, Group 2, and Group 3, respectively. For apoptosis and caspase-3 immunoreactivity of the exogenous apoptosis pathway, no immunopositive reactions were observed in Group 1.
Conclusion: For the occurrence and formation mechanisms of vasospasm after subarachnoid hemorrhage, this pathological condition is thought to result from multifactorial and various biochemical reactions. In our study, it was found that psalmotoxin effectively prevented vasospasm and significantly reduced tissue damage after vasospasm.
The value of albumin-related ratios in predicting disease severity and mortality in acute cholangitis
Authors: YEŞİL Bayram , SEVİM Bünyamin 
Published: December 2023

Aims: Acute cholangitis is a potentially fatal bacterial illness that poses a significant risk to patients if not promptly addressed, despite the progress made in the field of diagnosis and treatment. Multiple laboratory and clinical data are employed in assessing the severity and fatality rates associated with acute cholangitis. This study aimed to assess the predictive utility of the ratio between elevated laboratory results and albumin levels in determining the severity of disease and mortality rates in patients with cholangitis.
Methods: The study comprised a cohort of 471 individuals diagnosed with acute cholangitis, alongside a control group of 150 individuals without acute cholangitis. The patients' information was acquired by conducting a retrospective search of the computerized database. The study collected data on the age, gender, routine laboratory parameters, concomitant disorders, etiology of cholangitis, and outcomes (discharge or death) of all patients. The patients were categorized into three grades, namely grade 1, grade 2, and grade 3, based on the severity of cholangitis, using the Tokyo 2018 standards as a reference.
Results: The study comprised a sample size of 621 people. Out of the whole sample size, 53.1% (330 individuals) were identified as male. The study observed a broad range of ages (23-98) with a median age of 67 years, which was found to be greater in the cholangitis group. Among the patients in the cholangitis group, a mortality rate of 6.8% (32 individuals) was observed. A notable disparity was seen in all laboratory parameters between the two groups. The cholangitis group had greater levels of albumin-related ratios, and there was a positive correlation observed between all ratios and the severity of the condition. In deceased individuals, there were greater rates observed for variables other than the γ-glutamyl transferase/albumin ratio (GAR). The results of both univariate and multivariate regression analyses demonstrated a significant correlation between the ratios of direct bilirubin to albumin (DBAR), international normalized ratio to albumin (IAR), neutrophil to albumin (NAR), and mortality. Additionally, the study revealed that the mortality and severity of cholangitis could be predicted by all the albumin-related ratios examined, particularly the INR/albumin ratio (IAR), as indicated by the ROC analysis.
Conclusion: It is posited that the utilization of albumin-related ratios, obtainable through routine laboratory testing, may serve as an effective means to assess the severity of acute cholangitis and predict mortality rates associated with the condition. Immediate biliary drainage is recommended for patients with elevated ratios.
Distribution of bacteria isolated from urine cultures and resistance pattern of Escherichia coli strains in community-acquired urinary tract infections
Authors: BULUT Dilek , KARAKOÇ Hanife Nur 
Published: December 2023

Aims: Urinary tract infections are one of the most common among community-acquired infections. Escherichia coli (E. coli) is the most common cause of community-acquired urinary tract infections. In our study, we aimed to determine the correct empirical treatment by determining the resistance profile of E. coli strains isolated from urine cultures in our hospital, thus both establishing an effective treatment and preventing the development of resistance.
Methods: Urine cultures of 3145 patients with urinary tract infection symptoms who applied to the infection and clinical microbiology outpatient clinic of our hospital between January 2019 and December 2019 were analyzed retrospectively. Patients with a history of catheter, a history of urinary operations, a history of hospitalization in the last 15 days, contamination in their cultures, and patients under the age of 18 were excluded from the study, and 422 urine cultures with growth were included in the study.
Results: The mean age of the patients included in the study was 49.8±14.7 years, and the gender distribution consisted of 301 females (71.3%) and 121 males (28.7%). E. coli was isolated in 313 (77.6%) of these cultures. The antibiotic with the highest resistance rate was trimethoprim-sulfametoxazole (34.8%), while the antibiotics with the lowest resistance rates were fosfomycin and imipenem (0.6%).
Conclusions: Considering that the resistance profiles of microorganisms are different from each other on the basis of country, region, and city, revealing regional resistance patterns can make an important contribution to both establishing effective treatment and preventing the development of antibiotic resistance.
Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria
Authors: ÖRNEK ÖZDEMİR Sinem , ÖZGÜR Emek 
Published: December 2023

Aims: Chronic spontaneous urticaria (CSU) is one of the most prevalent skin disorders. Helicobacter pylori (HP) infection has been linked to CSU, and HP eradication therapy has been questioned as a viable treatment option. However, studies have produced contradictory results. In addition, recent studies suggest that gastritis, rather than HP bacteria, may be responsible for CSU symptoms. Herein, we aimed to ascertain the prevalence of HP infection in CSU, explore associations between HP infection, gastritis, and CSU severity or treatment response in CSU, and investigate the impact of HP eradication therapy on the CSU course.
Methods: We retrospectively analyzed CSU patients who were investigated for HP infection. Patient characteristics, in-clinic urticaria activity scores (ic-UAS) and urticaria control test (UCT) scores, and CSU treatment responses were compared across different patient groups.
Results: The study included 325 CSU patients, of whom 57.2% were HP-positive and 60.9% had gastritis. The mean baseline ic-UAS showed no difference between HP-positive and HP-negative patients (2.55±2 vs 2.45±1.98, p>0.05) or between patients with and without gastritis (2.33±2 vs 2.51±2, p>0.05). HP-positive patients had higher rates of elevated CRP levels (45% vs 29.9%, p=0.023) and ASST positivity (54.8% vs 29.8%, p0.05).
Conclusion: Over half of CSU patients have been found to be infected with HP. However, the HP bacterium itself, the eradication of HP, or gastritis have no significant effect on CSU severity or treatment response.