bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrothermal synthesis of hydroxyapatite crystals with and without seed crystals and surfactant
Authors: Abdel-Aal E. A. , El-Sayed D. , Abdel-Ghafar H. M. 
Published: November 2023

Abstract

To the best of our knowledge for the first time the hydroxyapatite (HA) crystals were synthesized with different doses of HA seed crystals. HA crystals were synthesized from solutions containing the stoichiometric amounts of ammonium dihydrogen phosphate and calcium hydroxide. The various interactions of the NH4H 2PO4 concentrations (0.5–5.5 Molar), surfactant {amino tris (methylene phosphonic acid) [N(CH2PO3H2)3] (ATMP)} [ATMP] concentrations (0 - 100 ppm), and HA seed crystals doses (0 – 50%) were investigated and their effects on the HA mean diameter and hardness were studied using the Box-Behnken experimental statistical design. Results have shown that no correlations were obtained between the mean diameters of the HA crystals and the obtained HA hardness. HA synthesis in the absence of surfactant resulted in formation of HA rod-like and/or tabular crystals whereas agglomerated crystals were obtained with surfactant. The results indicate that with increasing the % of HA crystal seed dose, an increase in the HA mean diameter was obtained. Moreover, with increase of surfactant concentration, a high increase in HA hardness was achieved. HA crystal particle sizes were ranged from about 11 µm to 18 µm whereas the crystallite sizes were ranged from 22 nm to 46 nm.
Psychological health ramifications of sea-level rise in Bangladesh coastal populations
Authors: Kabir Sajjad , Newnham Elizabeth A. , Dewan Ashraf , Islam Md Monirul , Hamamura Takeshi 
Published: November 2023

Abstract

This study investigates relatively unexplored impact of sea-level rise (SLR) on the psychological health of coastal populations. A longitudinal research design was employed, involving 1,144 participants from coastal communities in Bangladesh with different degree of vulnerability. Data collection phases included before and after the monsoon season of 2021. This research demonstrates that psychological health, particularly distress, depression, anxiety, and stress deteriorate markedly during the post-monsoon months (October-November) in communities more vulnerable to SLR. This deterioration is linked to an increase in environmental stressors and a sense of resource loss with the latter mediating the relationship. Additionally, we found a decrease in resilience and an increase in COVID-19 anxiety. This research illuminated multifaceted relationships between SLR, environmental stress, resource loss, and psychological health, providing valuable insights to inform the development of tailored interventions and policies for supporting the wellbeing of coastal populations, affected by growing risk of SLR.
Delay in Clearance of Labeled Protons Post Acute Head Trauma Utilizing 3D ASL MRI (Arterial Spin Labeling) a Pilot Study
Authors: Joseph Charles , Kang Jubin , Grohol Bryce , Zivcevska Marija , Lencke Joshua , Rich Ethan , Arrasmith Connor , Dorman Ian , Clark Bradley , Love Kim , Ferry Ben , Rolfs Mark 
Published: November 2023

Abstract
This study correlated mild traumatic brain injury (mTBI) cognitive changes with ASL-MRI glymphatic clearance rates (GCRs) and recovery with GCR improvement. . mTBI disrupts the blood brain barrier (BBB), reducing capillary mean transit time (cMTT) and GCRs. mTBI is clinically diagnosed utilizing history/examination findings with no physiologic biomarkers.
3D TGSE (turbo-gradient spin-echo) PASL (pulsed arterial spin-labeling) 3T MRI with 7 long TIs (inversion times) assessed the signal clearance of labeled protons 2800-4000 ms postlabeling in bifrontal, bitemporal, and biparietal regions within 7 days of mTBI and once clinically cleared to resume activities. The Sport Concussion Assessment Tool Version 5 (SKAT5) and Brief Oculomotor/Vestibular Assessment evaluated injured athletes’ cognitive function prior to MRIs.
The pilot study demonstrated significant GCRs improvement (95% [CI] -0.06 to -0.03 acute phase; to [CI] - recovery [CI] 0.0772 to -0.0497; P <0.001 in frontal lobes; and parietal lobes (95% [CI] -0.0584 to -0.0251 acute; [CI] -0.0727 to -0.0392 recovery; P = 0.024) in 9 mTBI athletes (8 female, 1 male). Six age/activity-matched controls (4 females, 2 males) were also compared.
mTBI disrupts the BBB, reducing GCR measured using the 3D ASL MRI technique. ASL MRI is a potential noninvasive biomarker of mTBI and subsequent recovery.
Morphometric Variations in Golden Jackal (Canis aureus) in Somogy County, Hungary
Authors: Csányi Erika , Sándor Gyula 
Published: November 2023

Abstract
The golden jackal (Canis aureus) is a canid species broadly distributed across Europe, including Hungary, where its population has increased exponentially in recent decades. Despite its expanding range and ecological relevance, comprehensive morphometric studies on the golden jackal in Hungary are lacking. Skull and body morphologies represent population/individual traits, genetic distances, environmental impacts, and growth variables, making morphological study essential. We conducted Hungary's first comprehensive body and skull morphometry examination of golden jackals.Between January 2021 and January 2023, we performed morphometric measurements on 754 golden jackals at two developmental stages, juveniles and adults, of different sexes (male and female) in Somogy County, Hungary. We found evidence of sexual dimorphism in all seven body measurements, which were greater in males than in females. We also demonstrated sexual dimorphism in most craniometric measurements (19/21), which were also larger in males. Most skulls differed significantly in size between the sexes and age groups, whereas postoperative breadth and foramen magnum height were not significantly different. Our results can contribute to a better understanding the ecology, behavior, and adaptation of golden jackals in the overpopulated Hungarian habitat, providing valuable insights for future conservation and management efforts."
Impact of Neutrophil Gelatinase-associated Lipocalin A Novel Sepsis Biomarker on PRISM III Score in Predicting Sepsis Severity And Mortality in Pediatric Intensive Care Units (Single Center Study)
Authors: Abdelrazic Marwa Ibrahem , Hakeem Gehan Lotfy Abdel , Mohamed Omima Mohamed , Hanna Mina Sobhy , Abuelela Ebtehal Saad 
Published: November 2023

Abstract
Background: Physiological, pathological, and metabolic problems brought on by infection are what define the syndrome of sepsis. Neutrophil granules generated at human sites of infection and inflammation were the source of the first discovery of neutrophil associated gelatinase associated lipocalin (NGAL).
Objectives: to evaluate the predictive usefulness of serum NGAL in children with sepsis in the pediatric intensive care unit and to compare it with the clinical score (PRISM III score) that is most frequently used to predict mortality in critically unwell children. ).
Patients and methods: In this study 75 patients were included according to the inclusion criteria and divided into three groups 25 each (sepsis, septic shock, and multi-organ failure), and serum NGAL level in those group was measured and compared to 25 healthy controls.
Results: Serum NGAL was significantly higher in both septic shock and multi-organ failure groups than in the control group. Positive bacterial cultures were linked to the severe degrees of sepsis which were associated with higher serum NGAL levels. Significant difference in serum NGAL level was found between survivors and non survivors, while no significant difference was found regarding PRISM III score.
Conclusion: Serum NGAL is significantly elevated in severe sepsis. Serum NGAL level was superior on the frequently used PRISM III score to predict mortality in critically ill patients with sepsis. So, serum NGAL can be used as a marker for severity and prognosis for mortality in septic pediatric patients.
Malnutrition in Children Under Five Years in a Squatter Settlement of Karachi; a Case-control Study
Authors: Ara Gati , Fawad Bina , Shabbir Shumaila 
Published: November 2023

Abstract
Background: Multidimensional factors such as socioeconomic or environmental factors influence malnutrition. Several studies have linked malnutrition strongly to poverty. Some international studies point to worse nutritional status of urban slum children compared to rural children. Not much data is available regarding the nutritional status of slums’ children in Karachi. This study aims to find characteristics of malnourished children in an urban squatter settlement of Karachi, Pakistan.
Methods: A Case- Control study was done in the primary healthcare centre of a squatter settlement of Karachi, Pakistan. All children under five years visiting the primary healthcare centre were recruited consecutively. Cases were defined as children with z scores < -2 SD of WHO reference measurements of WFA, HFA, WFH and OFC. Controls were similar age group and but had z scores between -2SD and +2SD. Face to face interviews were carried out with the mothers included information about socio-demographic, economic and environmental and child related characteristics. Univariate and multivariate logistic regression were conducted. Crude and adjusted odds ratio were calculated with 95% confidence interval.
Results: A total of 280 participants including 140 cases and 140 controls participated in the study. A larger proportion originated from low household income. After adjusting for all confounders, childhood malnutrition was significantly associated with low education of father (aOR 4.86, 95% CI 2.23-10.60), monthly income less than 25,000 PKR a month (aOR 7.13, 95% CI 1.67-30.54), pour pit latrine type of toilet (aOR 4.41, 95% CI 2.67-7.3), less than six months exclusive breast feeding (aOR 3.578, CI (1.58-8.08), inappropriate weaning age (aOR3.71, 95% CI 1.53-9)
Conclusion: Malnutrition in under five children of the community is associated with low family income, low paternal education, and poor toilet facilities as well as inappropriate breast feeding and weaning practices. Implementation of poverty reduction programmes and sanitation provision at affordable rates is needed. A community-based breast feeding and weaning education intervention is urgently needed to efficiently improve child nutritional status.
Management of MPS-I using ERT: The Egyptian experience
Authors: Fateen Ekram , Sahrigy Sally A. F. El , Ibrahim Mona , elhossini rasha , Ahmed Hoda H. , Ismaeel Asmaa , Radwan Amira , Salama Iman Ibrahim , ElBaky Abeer M. NourElDin Abd , Ezzeldin Nada , Rahman Azza M.O. Abdel , Aglan Mona 
Published: November 2023

Abstract

Background Mucopolysaccharidosis type I (MPS I) is an autosomal recessive multisystem lysosomal storage disorder. Methods Herein, we report the Egyptian experience of enzyme replacement therapy (ERT) for MPS type I patients and the faced challenges. Thirty-eight MPS-I patients were examined at presentation and throughout ERT to evaluate its effect on different body systems. Clinical and radiological examination of the patients confirmed the characteristic manifestations. Results Follow up after one year of ERT initiation revealed improvement of respiratory function tests, significant decrease in the size of liver and spleen, a stationary course of cardiac problems and a decrease of total urinary glycosaminoglycans (GAGs) levels. We experienced the problems of late presentation, time consuming procedures to get approval for ERT and receiving the treatment thus, leading to delayed ERT initiation in addition to irregular interrupted ERT courses due to delay in treatment renewal and difficulties in patient’s transportation from far governorates. Laronidase was generally well tolerated apart from mild infusion-related adverse reactions. Conclusion ERT is an effective treatment in the management of MPS-I patients. Early diagnosis, less complicated process for treatment approval, effecient multidisciplinary centers that are aware of the disease manifestations and able to provide ERT are recommended.
Psychological Mechanisms of Revenge and Revenge Ideations in Family Homicide: Results from Qualitative Research of Forensic Assessment Reports
Authors: Grobbink Leonie H. , Huijbregts Klaas M. L. , Draisma S. , Derksen Jan J.L. , Westerhof Gerben J. 
Published: November 2023

Abstract
Our aim was to find out which social and psychological factors characterize forensic psychiatric patients who have committed family homicide with revenge as a reason as compared to subjects who committed family homicide with other motives. Qualitative research was carried out on the basis of pre-trial forensic assessment reports of existing cases (N = 20), divided between Revenge and No-Revenge cases. In case of revenge, violence was almost always a sort of settling of an interpersonal score. Psychotic symptomatology was absent in the Revenge cases, personality problems (particularly borderline and narcissistic traits) were common. Demoralization because of a decline of well-being seems to be an important factor pushing some persons with such vulnerabilities over the edge. Our expectation is that, at least in a certain proportion of (non-psychotic) patients, there will be more brooding on revenge than the psychotherapist suspects.
SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation
Authors: Wasai Yuki , Yamada Naoyuki , Ariyoshi Nobuaki , Haraguchi Aiko , Funatsu Masahiko , Mikuni Masanori , Nakamura Riku , Sakuma Ayano , Higashijima Fumiaki , Iwamoto Nanako , Teranishi Shinichiro , Nishioka Mitsuaki , Yamasaki Takahiro , Kimura Kazuhiro 
Published: November 2023

Abstract
The potential risks associated with organs from COVID-19-infected donors were unclear. To determine the SARS-CoV-2 infection status of corneas transplanted during the COVID-19 pandemic, we performed a polymerase chain reaction (PCR) using the corneal preservation solution that was used for corneal transplantation. We also examined the postoperative health status of the recipients. This study included 144 transplants in 143 eyes. Ninety-nine eyes of imported corneas and 10 of the 14 corneas donated in the prefecture were PCR tested at our hospital, and all were SARS-CoV-2 negative. All corneal transplants were performed after confirming their SARS-CoV-2 negativity by a PCR using a corneal preservation solution at our hospital or a nasopharyngeal swab at a previous facility. Despite postoperative steroid administration, no patient developed COVID-19 infection until discharge. Hence, if the donor's nasopharyngeal swab test is SARS-CoV-2 negative, COVID-19 infection in the recipient due to corneal transplantation may be prevented. Since corneal transplant recipients are susceptible to infection due to prolonged steroid administration and are at high risk for severe diseases if infection occurs, SARS-CoV-2 detection testing using nasopharyngeal swabs in donors should be performed.
Caputo-hadamard Fractional Differential Equations: Integral Boundary Condition System
Authors: MURAD SHAYMA A. , RAFEEQ AVA SH. , IBRAHIM RABHA W. , Ahmad Hijaz , Almohsen Bandar 
Published: November 2023

Abstract
The solvability of a fractional differential equation depends on various factors such as the type of equation, the order of the fractional derivative, the domain and boundary conditions, and the properties of the solution sought. In this paper, The solution of a system of Caputo-Hadamard fractional differential equations (SCH) with integral boundary condition is investigated. The existence theorem of solutions is established by means of the Krasnoselskii and Schaefer’s fixed point theorem. Further, the uniqueness result is presented which is based on Banach’s contraction principle. Finally, the stability of the given system in Ulam-Hyers sense is applied. Examples are considered for the verification of theoretical works.
Effects of Light Treatments on Callus Induction and Morphogenesis in Caladium bicolor
Authors: Chen Mengyi , Xie Jiangjiang , Guan Jinyan , Chen Shuangyan , Huang Haiying , Luo Qingwen , Wang Qihua 
Published: November 2023

Abstract

Caladium bicoloris widely used as an ornamental plant outdoors and indoors due to its rich colors, diverse combinations, and strange patterns. In the commercial production ofCaladium bicolor, tissue culture technology can quickly reproduce seedlings with consistent genetic properties. In practice, there are still aspects that can be improved in terms of energy dissipation and ornamental value when using fluorescent lamps. In this experiment, the light intensity had no significant effect on the induction of callus and the germination rate, but from the number of buds per explant increased. Different light waves affect the occurrence of seedlings ofCaladium bicolor. Among them, a single light source, LED-Red, is not conducive to callus differentiation, plant height, and carotenoid accumulation compared to other treatments; LED-Blue is beneficial for the formation of relative anthocyanin content and plant height.LED-White is beneficial for leaf size. Fluorescence is not conducive to increasing the total number of seedlings, which is important for production. Compared with fluorescence, the transplanting rate of LED-Blue increased by 94.92%. The results of this experiment suggest that LED light can replace florescent lamps in tissue culture for achieving low energy consumption and high efficiency.
Structure prediction of protein-ligand complexes from sequence information with Umol
Authors: Bryant Patrick , Kelkar Atharva , Guljas Andrea , Clementi Cecilia , Noé Frank 
Published: November 2023

Abstract

Protein-ligand docking is an established tool in drug discovery and development to narrow down potential therapeutics for experimental testing. However, a high-quality protein structure is required and often the protein is treated as fully or partially rigid. Here we develop an AI system that can predict the fully flexible all-atom structure of protein-ligand complexes directly, given a multiple sequence alignment representation of the protein, protein pocket information and a SMILES string representing the ligand. At a high accuracy threshold, unseen protein-ligand complexes can be predicted more accurately than for RoseTTAFold-AA, and at medium accuracy even classical docking methods that use known protein structures as input are surpassed. The high accuracy presented here suggests that the goal of AI-based drug discovery is one step closer, but there is still a way to go to fully grasp the complexity of protein-ligand interactions. Umol is available at: https://github.com/patrickbryant1/Umol
A Novel Nature-Inspired Magnetic Hydrogel Coated with Graphene Oxide for the Efficient-Sustained Release of Levodopa
Authors: K Athira , Kumar B Siva , Reddy S Giridhar , K Prashanthi 
Published: November 2023

Abstract
Parkinson's disease (PD) is a neurological condition characterized by the destruction of neurons in the central nervous system. Levodopa, an amino acid that is a precursor to dopamine, is prescribed as a treatment for PD. In this paper, the magnetic hydrogel was prepared using sodium alginate (SAl) and lignosulphonic acid (LSA) as green polymers, crosslinked with Ba2+ ions, and coated with Fe3O4-GO (Graphene Oxide) nanoparticles, which could increase the bioavailability of levodopa at the target site (brain) and achieve a better stimulus responsive targeted therapeutic effect. The synthesized hydrogel was characterized, and the multiple variants were evaluated for their in-vitro drug release. The highest drug loading efficiency of 69.67% was observed in the SAl-LSA-GO-LD (LD 3) film leading to the best-sustained release of levodopa as expected, with a 24% release followed by other variants. Combining sodium alginate (SAl) and lignosulphonic acid (LSA) hydrogel coated with Fe3O4 and graphene oxide nanoparticles is a novel, efficient methodology for the controlled release of levodopa.
Combinatorial cooperativity can facilitate epithelial-mesenchymal transition in a miR200-Zeb transcriptional network
Authors: Rashid Mubasher , Devi Brasanna M , Banerjee Malay 
Published: November 2023

Abstract
Carcinomas often utilize epithelial-mesenchymal transition (EMT) programs for cancer progression and metastasis. Numerous studies report SNAIL-induced miR200/Zeb feedback circuit as crucial in regulating EMT by placing cancer cells to at least three (epithelial (E), hybrid (h-E/M), mesenchymal (M)) phenotypic states along the E-M phenotypic spectrum. However, a coherent molecular-level understanding of how such a tiny circuit controls carcinoma cell entrance into and residence in various states is lacking. Here, we use molecular binding data and mathematical modeling to report that miR200/Zeb circuit can essentially utilize combinatorial cooperativity to control E-M phenotypic plasticity. We identify minimal combinatorial cooperativities that give rise to E, h-E/M, and M phenotypes. We show that disrupting a specific number of miR200 binding sites on Zeb as well as Zeb binding sites on miR200 can have phenotypic consequences – the circuit can dynamically switch between two (E, M) and three (E, h-E/M, M) phenotypes. Further, we report that in both SNAIL-induced and SNAIL knock-out miR200/Zeb circuits, cooperative transcriptional feedback on Zeb as well as Zeb translational inhibition due to miR200 are essential for the occurrence of intermediate h-E/M phenotype. Finally, we demonstrate that SNAIL can be dispensable for EMT, and in the absence of SNAIL, the transcriptional feedback can control cell state transition from E to h-E/M, to M state. Our results thus highlight molecular-level regulation of EMT in miR200/Zeb circuit and we expect these findings to be crucial to future efforts aiming to prevent EMT-facilitated dissemination of carcinomas.
Anti-NMDAR encephalitis with MOGAD overlap syndrome, isolated epilepsy, and unilateral thalamus changes: a case report and literature review
Authors: Zhong Rimei , Chen Xiongjin , Liao Feng , Lin Zhijun , Zhang Zhijian , Chen Yusen , Cui Lili 
Published: November 2023

Abstract
Background
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune brain disease mediated by antibodies and characterized by psychiatric symptoms, seizures, behavioral abnormalities, dyskinesia, and cognitive impairment. Recently, the co-existence of anti-NMDAR IgG and MOG IgG has been reported, and anti-NMDAR encephalitis has been found to occur concurrently or successively with demyelinating disease. With gradually increasing reports, the coexistence of anti-NMDAR-IgG and MOG-IgG has been noticed by scholars, and the combination of MOG antibody disease with anti-NMDAR encephalitis is called MOG antibody disease and anti-NMDAR encephalitis overlap syndrome (MNOS). MNOS is clinically rare, and due to its atypical clinical characteristics and its imaging manifestations, the disease is poorly understood, making clinical diagnosis difficult. Seizures are one of the most common atypical symptoms, and cases of mono antibody disease with bilateral thalamus symmetric involvement have also been reported, among which isolated seizures and MNOS cases of unilateral thalamus involvement have not been reported in the literature.
Case presentation:
A 29-year man was admitted to our hospital with isolated seizures, who had unilateral thalamic involvement and showed anti-NMDAR-IgG and MOG-IgG positivity in both cerebrospinal fluid and serum. His symptoms responded to immunotherapy and antiepileptic drugs with a good prognosis. To the best of our knowledge, this is the first case report of a double antibody-positive case with isolated seizures and unilateral thalamic involvement.
Conclusions
Our case is a reminder that we clinicians should think of MNOS when patients present with atypical clinical manifestations like epilepsy and test both serum and cerebrospinal fluid for multiple associated autoantibodies (including MOG antibodies) and viruses to avoid misdiagnosis, missed diagnosis, and impact on prognosis. In addition, it enriches the disease spectrum of MNOS syndrome.