bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Effects of PTH (1-34), PTHrP (1-36), and Abaloparatide on the Murine Osteoblast Transcriptome
Authors: Mosca Michael J , He Zhiming , Ricarte Florante R , Le Henaff Carole , Partridge Nicola C 
Published: December 2023

Abstract
Teriparatide (PTH (1-34)), PTHrP (1-36), and abaloparatide (ABL) have been used for the treatment of osteoporosis, but their efficacy long term is significantly limited. The 3 peptides exert time- and dose-dependent differential responses in osteoblasts, leading us to hypothesize they may also differentially modulate the osteoblast transcriptome. Treatment of mouse calvarial osteoblasts with 1 nM of the peptides for 4 hours results in RNA sequencing data with PTH (1-34) regulating 367 genes, including 194 unique genes; PTHrP (1-36) regulating 117 genes, including 15 unique genes; and ABL regulating 179 genes, including 20 unique genes. There were 83 genes shared among all 3 peptides. Gene ontology analyses showed similarities in Wnt signaling, cAMP-mediated signaling, ossification, but differences in morphogenesis of a branching structure in biological processes; receptor ligand activity, transcription factor activity, and cytokine receptor/binding activity in molecular functions. The peptides increased Vdr, Cited1, and Pde10a messenger RNAs (mRNAs) in a pattern similar to Rankl, that is, PTH (1-34) greater than ABL greater than PTHrP (1-36). mRNA abundance of other genes, including Wnt4, Wnt7, Wnt11, Sfrp4, Dkk1, Kcnk10, Hdac4, Epn3, Tcf7, Crem, Fzd5, Ppp2r2a, and Dvl3, showed that some genes were regulated similarly by all 3 peptides; others were not. Finally, small interfering RNA knockdowns of SIK1/2/3 and CRTC1/2/3 in PTH (1-34)–treated cells revealed that Vdr and Wnt4 genes are regulated by salt-inducible kinases (SIKs) and CREB-regulated transcriptional coactivators (CRTCs), while others are not. Although many studies have examined PTH signaling in the osteoblast/osteocyte, ours is the first to compare the global effects of these peptides on the osteoblast transcriptome or to analyze the roles of the SIKs and CRTCs.
Bibliometric Analysis of Contributions of Anesthesiology Journals and Anesthesiologists to Operating Room Management Science
Authors: Dexter Franklin , Scheib Sara , Xie Wei , Epstein Richard H. 
Published: December 2023

BACKGROUND:
Anesthesiology journals appear to have been progressively publishing a smaller percentage of operating room (OR) management studies. Similarly, non-anesthesiologists have increasingly been authors of these publications. Five hypotheses were formulated to evaluate these impressions based on 2 of the authors’ curation of an online, comprehensive bibliography of OR management articles and corresponding referenced course materials.

METHODS:
We studied all 2938 publications having Scopus’ SciVal topic T.6319 (OR management) more than 28 years from 1996 through May 2023, including 8608 distinct authors.

RESULTS:
Half (50%) of the publications were absent from PubMed, and the percentage absent has been increasing progressively (Kendall’s τ = 0.71; P < .0001). Fewer than half were published in journals including anesthesiology as the sole classification (20%) or as one of the classifications (27%). The anesthesiology journals have been publishing a progressively decreasing fraction (τ = −0.61; P < .0001). Among the 11 authors each contributing at least 1% of the OR management science publications, 9 were anesthesiologists and the other 2 had anesthesiologists as coauthors on all these publications. Only 3% of authors had at least 10 OR management publications from earlier years. There were 75% of authors with no such earlier publications and 85% with 0 or 1. There was a progressive increase in the number of authors publishing OR management annually and with at most 1 such earlier publication (τ = 0.90; P < .0001). Only 20% of publications had any author with at least 10 earlier OR management publications, 48% had every author with no such earlier publications, and 60% had all authors with 0 or 1.

CONCLUSIONS:
Although most of the authors with the greatest production of OR management science were anesthesiologists, the percentage of publications in anesthesiology journals has been decreasing progressively. Anesthesiologists cannot rely solely on anesthesiology journals to keep up with the field. For most publications, every author had few or no earlier publications on the topic. Clinicians and managers relying on OR management science will continue to need to apply more information when judging whether published results can reliably be applied to their facilities.
A reliable technique for karyotyping mouse oocytes prepared by a gradual fixation/air-drying method followed by multicolour FISH
Authors: Hino Toshiaki , Kusakabe Hirokazu 
Published: December 2023

ABSTRACT
Chromosome segregation errors during oocyte meiosis increase with age and lead to aneuploidy; hence, the mechanism has been studied extensively. The mouse is the most widely used experimental animal for this purpose. However, the lack of a reliable and efficient technique for karyotyping mouse oocytes has limited comprehensive studies of chromosome-specific segregation errors in this animal model. Here, we developed a novel karyotyping technique for mouse oocytes by applying multicolour fluorescence in situ hybridisation (FISH) to chromosome slides prepared by a gradual fixation/air-drying method, which is best suited to avoid rupture of oocyte membrane and artificial loss of chromosomes. The success rate of karyotyping meiosis I and II oocytes was about 30%, which improved to over 90% when the oocytes were ‘flattened’ during fixation and the chromosome specimens were denatured at 4°C. When this technique was applied to the karyotyping of meiosis II oocytes from aged female mice and from young female mice injected with colchicine, more than 80% of the oocytes were successfully karyotyped and the number of chromosomes was identified on all aberrant chromosomes. In conclusion, our technique allows for the efficient and reliable karyotyping of mouse oocytes.
Stockpiling at the Onset of the COVID-19 Pandemic: An Empirical Analysis of National Prescription Drug Sales and Prices
Authors: Park Minje , Carson Anita L. , Fox Erin R. , Conti Rena M. 
Published: December 2023

At the onset of the coronavirus (COVID-19) pandemic, hospitals experienced a demand surge for COVID-19–related medical care while simultaneously struggling to source prescription drugs needed to manage COVID-19 patients. This is worrisome as shortfalls in the supply of essential drugs can negatively impact patient outcomes. The popular press reporting on these challenges suggests that they are caused by supply chain disruptions. However, rigorous research on the relationship between the pandemic and prescription drug supply is limited. To address this gap, we leverage a quasi-experimental design and IQVIA’s National Sales Perspectives™ data from 2018 to 2020. We focus on prescription drugs indicated for the management of COVID-19 patients and a set of control drugs (i.e., drugs not used for COVID-19). We find that in the early phases of the pandemic, hospitals stockpiled prescription drugs indicated for the management of COVID-19, making this behavior an under-recognized cause of the sourcing challenges. The sales volume of drugs indicated for COVID-19 management was concentrated in the first two months of the pandemic, after which sales decreased significantly despite a nationwide increase in COVID-19–related hospitalizations. We investigate another potential cause of stockpiling: expected price increases. Counter to concerns of price gouging, we find little evidence of price inflation for these drugs. An implication for drug manufacturers is that orders due to stockpiling by downstream buyers early on in a pandemic may need to be discounted when predicting future demand. Our results have implications for drug suppliers, hospitals, and policymakers interested in improving medical product supply chain resilience. This paper was accepted by Stefan Scholtes, healthcare management. Funding: R. M. Conti was supported by the National Science Foundation (Grant 1123649-463157) and the Sloan Foundation. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2021.04150 .
Strategies to facilitate upscaling midwifery practice in South African public maternity units
Authors: James Sindiwe , Wibbelink Margreet , Thomson Ann 
Published: December 2023

Background/Aims Various models have been proposed to reduce rates of maternal mortality, aimed at addressing the diverse range of causes. Many of these models focus on using midwifery practice to achieve these goals. The aim of this study was to develop strategies to facilitate upscaling midwifery practice in South African public maternity units. Methods A mixed-methods sequential exploratory research design was implemented using purposive sampling of midwives and postpartum women. Qualitative data were collected from 11 midwives and 11 postnatal women in the Eastern Cape province, while quantitative data were gathered from 314 midwives from across five South African provinces. Data were collected using semi-structured interviews and a self-developed questionnaire. Descriptive statistics were used to analyse quantitative data. Qualitative data were analysed thematically. Results The participants were committed to their work but barriers to practice were a cause of concern. Two strategies for woman-centered care were developed based on the challenges reported by midwives. To assist with up-scaling of midwifery clinical practice in South Africa, the strategies recommended providing an enabling work environment where midwives could be empowered to provide woman-centred care and women were empowered to receive this care and be educated in self-care practices. Conclusions The work environment for midwives in South African public maternity units is, at times, not of an acceptable standard because of concerns related to regulation and training. Recognition of midwifery practice as an autonomous profession will facilitate woman-centred practice.
Investigating the use and awareness of artificial sweeteners among diabetic patients in Bangladesh
Authors: Shil Aparna , Zhang Jufen , Chichger Havovi 
Published: December 2023

Background
As with many countries around the world, the incidence of diabetes in Bangladesh is increasing significantly. Whilst there is controversy in the field regarding the health impact of artificial sweeteners in Western communities, the link between sweetener consumption and awareness in Bangladesh has not been established.

Methods
In the present study, 260 diabetic patients completed a questionnaire survey to investigate the use and awareness of sweeteners and how this links to demographics and potential co-morbidities.

Results
Findings show that daily artificial sweetener consumption is significantly associated with hypertension but not other co-morbidities such as kidney disease or obesity. We further demonstrate that there is limited checking of artificial sweeteners in food or drink products by participants. the rurality of diabetic participants was found to significantly correlates with lower awareness of any health impact of artificial sweeteners.

Conclusions
The findings from this study demonstrate that there is a need to increase the awareness of artificial sweetener use in diabetic patients in Bangladesh. Combined with a more robust understanding of the health impact of artificial sweeteners, these findings suggest that there is potential to improve outcomes for diabetic patients by improving this awareness.
A Transesophageal Cardiovascular Intervention
Authors: Loch Alexander , Teoh Victoria Wen Yeng , Hilmi Ida Normiha 
Published: December 2023

Abstract
Endoscopic ultrasonography-guided transesophageal pericardiocentesis was performed for a posteriorly located effusion not amenable to transthoracic drainage in a 58-year-old woman with a history of recurrent breast adenocarcinoma who presented with dyspnea. The patient had a pericardial effusion that resulted in cardiac tamponade. Transthoracic pericardiocentesis was unsuitable because of the posterior location of the effusion. Pericardiocentesis via the transesophageal route was performed. The pericardial sac was punctured with a 19-gauge needle, and 245 mL of pericardial fluid were aspirated, resulting in the resolution of the tamponade physiology. Endoscopic ultrasonography-guided transesophageal drainage is a novel and promising therapeutic option for posteriorly located pericardial effusions.
Enhancing heat transfer in tube heat exchanger containing water/Cu nanofluid by using turbulator
Authors: Long Zhiqiang , Zhang Buqing , Liu Guoqing , Wu Zhengxin , Yan Qiang 
Published: December 2023

Abstract
In the current essay, the numerical investigation of heat transfer in an exchanger containing nanofluid with Cu nanoparticles in the presence of a new inserter is carried out. The equations governing the turbulent fluid flow have been solved utilizing single-phase models with the aid of the finite volume method in ANSYS-FLUENT software using the k-ε turbulence model for the Re number ranging from 4000 to 8000. Furthermore, the influence of Reynolds number, nanoparticle volume fraction, and geometric characteristics of turbulator on the friction factor and Nusselt number have been scrutinized. Outcomes reveal that the newly introduced inserter performs well and increases the Nusselt number by roughly 34–54 times and the friction coefficient by approximately 1.8–3.2 times compared to the smooth tube. It is also observed that a 2 % increase in the nanoparticles volume fraction has resulted in a rise in the Nusselt number by around 92 %. To attain the optimal performance of the presented turbulator, the longitudinal distance between the inserters is recommended as S/D = 5.27, for which Performance evaluation criteria values in the range of 3.01–9.23 in the Reynolds range under investigation are acquired.
Integral transforms involving a generalized k-Bessel function
Authors: Khammash Ghazi S. , Salim Tariq O. , Aydi Hassen , Khattab Noor N. , Park Choonkil 
Published: December 2023

Abstract
The main goal of this study was to look into some new integral transformations that are associated with a generalized

k

k

-Bessel function. Integral formulas for the generalized

k

k

-Bessel function have been established using the Laplace transform, Euler transform, Whittaker transform, and

k

k

-transforms. The results presented here have the potential to be helpful, and some special cases of corollaries are explicitly demonstrated.
Examining the design characteristics of a dual-material gate all-around tunnel FET for use in biosensing applications
Authors: Senthil Preethi , Nanjappan Vijayalakshmi 
Published: December 2023

Abstract
An inventive analytical model for a dual material gate-all-around tunnel FET with possible applications in biosensors is described in this study. The semiconductor device considered in this study has a gate-all-around configuration built with two distinct materials. Short-channel effects are avoided with the help of the surrounding gate to achieve flexibility. A breakthrough dual-material design with a nanocavity has been developed to render it viable for biosensing applications. To figure out Poisson’s equation and to derive its surface potential, the Finite Differentiation Method is used in this work. The electric field, subthreshold swing, drain current, and threshold voltage of the suggested structure are then determined using this potential. Furthermore, the device’s biosensor sensitivity is examined and the results are verified by two-dimensional TCAD simulations.
The Relationship Between Mental Fatigue and Shooting Performance Over the Course of a National Collegiate Athletic Association Division I Basketball Season
Authors: Daub Bryce D. , McLean Blake D. , Heishman Aaron D. , Peak Keldon M. , Coutts Aaron J. 
Published: December 2023

Abstract
Daub, BD, McLean, BD, Heishman, AD, Peak, KM, and Coutts, AJ. The relationship between mental fatigue and shooting performance over the course of a National Collegiate Athletic Association Division I basketball season. J Strength Cond Res 38(2): 334–341, 2024—The aim of this investigation was to examine the presence of mental fatigue and concurrent changes in shooting performance across various experimental weeks throughout a National Collegiate Athletic Association (NCAA) basketball season. Fifteen elite male NCAA Division I collegiate basketball players (age 20.2 ± 1.2 years, height 199.3 ± 7.1 cm, and body mass 93.1 ± 8.6 kg) volunteered for this study. Mental fatigue and basketball shooting performance was evaluated at 4 timepoints with varying seasonal demands: high game volume (GAME), high academic load (ACADEMIC), no games and no academic load (PRACTICE), and standard number of games and academic requirements (TYPICAL). Subjective mental fatigue increased significantly (p ≤ 0.05) from Pre to Post brief psychomotor vigilance test (PVT-B) measurements at the end of the ACADEMIC week (p = 0.002, d = 1.51) and from beginning to end of the ACADEMIC week (p < 0.001, d = 2.21). Ratings of mental effort were significantly increased during the ACADEMIC week (p < 0.001, d = 1.67). Recovery stress questionnaire (REST-Q) showed significant differences between week GAME and ACADEMIC with an increase in Social Stress (p = 0.001, d = 0.84), Fatigue (p = 0.021, d = 1.12), Disturbed Breaks (p = 0.024, d = 0.57), and Emotional Exhaustion (p = 0.035, d = 0.75). Lower shooting performance was observed during the ACADEMIC week from Pre to Post (p = 0.009, d = 0.35) and higher scores Pre to Post in the TYPICAL week (p = 0.008, d = 0.25). Basketball shooting performance was significantly reduced after increased levels of mental fatigue stemming from added academic stress. In addition, an increase in sport-specific training or games had no effect on subsequent basketball shooting performance. Special consideration should be given by coaches around examination periods because the existence of academic stressors can influence basketball shooting performance.
Prediction of One Repetition Maximum in Free-Weight Back Squat Using a Mixed Approach: The Combination of the Individual Load-Velocity Profile and Generalized Equations
Authors: Fitas Afonso , Santos Paulo , Gomes Miguel , Pezarat-Correia Pedro , Schoenfeld Brad J. , Mendonca Goncalo V. 
Published: December 2023

Abstract
Fitas, A, Santos, P, Gomes, M, Pezarat-Correia, P, Schoenfeld, BJ, and Mendonca, GV. Prediction of one repetition maximum in free-weight back squat using a mixed approach: the combination of the individual load-velocity profile and generalized equations. J Strength Cond Res 38(2): 228–235, 2024—We aimed to develop a mixed methods approach for 1 repetition maximum (1RM) prediction based on the development of generalized equations and the individual load-velocity profile (LVP), and to explore the validity of such equations for 1RM prediction. Fifty-seven young men volunteered to participate. The submaximal load-velocity relationship was obtained for the free-weight parallel back squat. The estimated load at 0 velocity (LD0) was used as a single predictor, and in combination with the slope of the individual LVP, to develop equations predictive of 1RM. Prediction accuracy was determined through the mean absolute percent error and Bland-Altman plots. LD0 was predictive of 1RM (p < 0.0001), explaining 70.2% of its variance. Adding the slope of the LVP to the model increased the prediction power of 1RM to 84.4% (p < 0.0001). The absolute percent error between actual and predicted 1RM was lower for the predictions combining LD0 and slope (6.9 vs. 9.6%). The mean difference between actual and estimated 1RM was nearly zero and showed heteroscedasticity for the LD0 model, but not for the combined model. The limits of agreement error were of 31.9 and 23.5 kg for LD0 and LD0 combined with slope, respectively. In conclusion, the slope of the individual LVP adds predictive value to LD0 in 1RM estimation on a group level and avoids error trends in the estimation of 1RM over the entire spectrum of muscle strength. However, the use of mixed methods does not reach acceptable accuracy for 1RM prediction of the free-weight back squat on an individual basis.
Effects of Two Different Low-Volume Resistance Training Programs Applied During the Off-Season Period on the Speed-Power Performance of Elite Youth Soccer Players
Authors: Loturco Irineu , Nunes Renan F. H. , Lampert Rodrigo R. , Silva Rodrigo L. P. , Hespanhol Jefferson E. , Novack Luiz F. , Conde Juan H. S. , Pereira Lucas A. , McGuigan Michael R. 
Published: December 2023

Abstract
Loturco, I, Nunes, RFH, Lampert, RR, Silva, RLP, Hespanhol, JE, Novack, LF, Conde, JHS, Pereira, LA, and McGuigan, MR. Effects of two different low-volume resistance training programs applied during the off-season period on the speed-power performance of elite youth soccer players. . J Strength Cond Res XX(X): 000–000, 2023—The aim of this study was to analyze the changes in the speed-power performance of elite youth soccer players submitted to 2 different low-volume resistance training programs during the off-season period. Twenty under-17 players were randomly allocated to “traditional nonballistic” or “ballistic training” groups. Countermovement jump (CMJ), 20-m sprinting speed, and half-squat (HS) power tests were performed after the final match of the season (pretesting session) and at the beginning of the subsequent season (post-testing session), after 4 weeks of detraining. Between-group differences were assessed using a 2-way ANOVA with repeated measures followed by the Tukey's post hoc test. Performance variations were individually analyzed with the use of the “true changes” calculation. At post-tests, CMJ height and HS power remained unchanged (p > 0.05) but similar and significant improvements in sprint speed were observed in both groups (p < 0.05). However, notably, a larger number of players in the ballistic group exhibited “true changes” in HS power (i.e., 55 vs. 33%, compared with the traditional group, respectively). In conclusion, either low-volume ballistic or traditional resistance training schemes were able to increase sprint speed and maintain power output during a short interseason break in youth soccer players. Despite this apparent similarity, at the individual level, ballistic movements were more efficient at improving lower-body power. Practitioners can use the strategies described here to improve the sprint and power performance of soccer players during short periods of soccer-specific training cessation.