bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning Operations (MLOps): Challenges and Strategies
Authors: Singla Amandeep 
Published: January 2024

Machine Learning Operations (MLOps) is a critical discipline that aims to streamline and enhance the end-to-end machine learning (ML) lifecycle, encompassing development, deployment, monitoring, and maintenance. As organizations increasingly adopt machine learning models to derive actionable insights and automate decision-making, MLOps becomes indispensable for ensuring efficiency, scalability, and reliability in ML workflows. This abstract explores the challenges encountered in implementing MLOps and presents strategies to overcome these hurdles.The challenges in MLOps can be categorized into technical, organizational, and cultural aspects. Technical challenges include model versioning, reproducibility, and ensuring consistent performance across diverse environments. Organizational challenges involve collaboration between cross-functional teams, managing diverse tools and frameworks, and integrating ML workflows with existing software development processes. Cultural challenges encompass resistance to change, skill gaps, and the need for a shared understanding of ML concepts among stakeholders.To address these challenges, a multifaceted strategy is proposed. Implementing robust version control systems and containerization techniques can enhance model reproducibility and deployment consistency. Cross-functional collaboration can be fostered through the establishment of dedicated MLOps teams, emphasizing communication and knowledge sharing. The integration of MLOps into existing DevOps practices can streamline workflows and mitigate organizational silos.Furthermore, the adoption of automated testing, continuous integration, and continuous deployment practices specific to ML can bolster the reliability of ML systems. Education and upskilling programs can bridge skill gaps, while promoting a culture of continuous learning and adaptability. Open-source MLOps tools and frameworks contribute to standardization and interoperability, facilitating smoother integration into diverse ecosystems.

In conclusion, the successful implementation of MLOps is crucial for organizations seeking to harness the full potential of machine learning. By addressing technical, organizational, and cultural challenges through a comprehensive strategy, businesses can establish resilient and efficient MLOps pipelines, paving the way for sustainable and scalable deployment of machine learning models.
Prevalence of Urinary Schistosomiasis Among Primary School Pupils in Keffi Local Government Area, Nasarawa State
Authors: Ndubuisi John , Yin'Allah M. V. 
Published: January 2024

Schistosomiasis, also known as bilharziasis or snail fever is primarily a tropical parasitic disease caused by eggs of adult stages of Schistosoma haematobium. Schistosomiasis has significant economic and public health consequences in many tropical and subtropical countries. This research aimed to determine the prevalence of urinary schistosomiasis among pupils of primary schools in Keffi LGA. A survey of S. haematobium was carried out among primary school pupils between the ages of 4 - 12 years in three primary schools that were selected randomly. A Questionnaire was administered to obtain demographic data. A total of 250 urine samples were examined, comprising 152 from males and 98 from females. The sedimentation technique was used, and urine deposits were examined microscopically. The overall prevalence of infection with Schistosoma haematobium in this study was 31.6%. Prevalence of disease varied among different schools, with the highest prevalence recorded at NSUK Demonstration School (20.8%) followed by LEA Primary School GRA (7.2%) while ECWA Primary School had the least prevalence of 3.6%. Males had 20.8% while females had 10.8% prevalence about Gender. Infection prevalence based on age was recorded as highest among the 10 – 12 age group with a prevalence of 20.4%. For prevalence based on source of water, those who used well water had a prevalence of 23.2%; while for prevalence based on parent’s occupation, Farmers had the highest with 22.4%. The study confirmed the prevalence of S. haematobium in the study area.
KEDEKATAN ANAK DAN IBU DALAM SUKU MINANGKABAU
Authors: Kurnia Sandra Annysa , Airlangga Cut Sarha , Hafiz Muhammad , Fadila Nurul , Maharani Puan 
Published: January 2024

Minangkabau merupakan salah satu suku yang ada di Indonesia yang menggunakan sistem kekerabatan matrilineal. Sistem kekerabatan matrilineal adalah di mana anak mengikuti garis keturunan ibu. Ibu dianggap lebih memiliki kedekatan dengan anak dibandingkan sang ayah. Hal ini dikarenakan ibu memiliki peran yang lebih besar dalam memberikan pengasuhan. Peran orang tua dalam pengasuhan dapat dipengaruhi oleh aturan adat yang dianut. Penelitian ini bertujuan untuk melihat kedekatan anak dan ibu dalam suku Minangkabau. Penelitian ini melibatkan responden sebanyak 103 orang yang bersuku Minangkabau dengan usia maksimal 27 tahun. pengumpulan data dilakukan dengan open questionnaire yang kemudian datanya diolah dengan menggunakan pendekatan analisis tematik. Hasil penelitian ini menjelaskan bahwa ibu dan anak dalam suku Minangkabau memiliki hubungan yang sangat dekat.
PENGARUH BRAND IMAGE DENGAN KEPUTUSAN PEMBELIAN TERHADAP SMARTPHONE IPHONE PADA MAHASISWA DI KOTA PADANG
Authors: Iskandar Aulia Ath Thaariq , Nio Suci Rahma 
Published: January 2024

Keputusan pembelian meupakan salah satu hal yang dimanfaatkan Perusahaan dalam menciptaan pemasaran di kehidupan sehari-hari. Perkembangan teknologi akan memberikan informasi yang baik terutama dalam pengenalan brand suatu produk. Brand image berperan sebagai sebagai salah satu penentu dalam keputusan pembelian oleh konsumen serta menjadi hal yang mendasar bagi produsen untuk menentukan skema marketing dan target pasar. Penelitian ini bertujuan untuk mengetahui pengaruh brand image terhadap keputusan pembelian Iphone pada mahasiswa di Kota Padang. Penelitian ini menggunakan metode kuantitatif dengan pendekatan regresi. Subjek pada penelitian ini berjumlah 272 mahasiswa Kota Padang yang memenuhi kriteria yang telah ditetapkan melalui teknik simple random sampling. Metode pengambilan data dalam penelitian ini menggunakan skala Likert. nilai reliabilitas keputusan pembelian sebesar 0. 826 dan skala brand image dengan reliabilitas sebesar 0. 867. Analisis data menggunakan linear sederhana dengan bantuan program Statistical Package for Sciences (SPSS) 26.0 for windows memperoleh hasil uji hipotesis dengan nilai koefisien regresi = 0.284 dengan nilai signifikansi p = 0.00 (p<0.05). Artinya terdapat pengaruh brand image terhadap keputusan pembelian produk Iphone pada mahasiswa di Kota Padang. Semakin tinggi brand image Iphone maka semakin tinggi keputusan pembelian. Kesimpulannya terdapat pengaruh brand image terhadap keputusan pembelian produk Iphone.
KONTRIBUSI FRIENDSHIP QUALITY TERHADAP HOMESICKNESS PADA SISWA BARU PEREMPUAN DI PONDOK PESANTREN KABUPATEN AGAMA
Authors: Muthi Muthi'ah Muthmainnah , Yasmin Maya 
Published: January 2024

Homesickness merupakan suatu perasaan kehilangan yang dialami oleh siswa yang terpisah dari lingkungan rumah sehingga menyebabkan siswa kerap merindukan rumah dan tidak bisa lepas dengan suasana rumah. Homesickness menjadi masalah yang perlu diatasi pada siswa baru karena memberikan dampak negatif terhadap keberlangsungan siswa di lingkungan pesantren. Penelitian ini bertujuan untuk melihat kontribusi friendship quality terhadap homesickness pada siswi baru perempuan pada pesantren di kabupaten Agam. Teknik pengambilan sampel menggunakan teknk Cluster sampling dengan partisipan berjumlah 140 siswi baru di Kabupaten Agam. Instrument penelitian yang digunakan ialah skala homesickness dan skala Friendship quality, kedua alat ukur disusun oleh peneliti berdasarkan dimensi homesickness yang dikemukakan oleh Stroebe dan Thien,Razak, dan Jamil (2017). Metode analisis data yang yang digunakan ialah teknik regresi linear sederhana. Hasil penelitian menunjukkan bahwa friendship quality berkontribusi terhadap homesickness dengan sumbangan efektif sebesar 12,4%. Implikasi dalam penelitian ini diperlukan untuk pihak pesantren dapat mengelola tingkat homesickness pada siswi baru pondok pesantren dengan melakukan intervensi serta meningkatkan kualitas pertemanan melalui kegiatan poisitif di lingkungan pesantren .
Effects of aspirin consumption during pregnancy on pregnancy outcomes: Meta‐analysis
Authors: Kozer Eran , Costei Adriana Moldovan , Boskovic Rada , Nulman Irena , Nikfar Shekoufeh , Koren Gideon 
Published: April 2003

AbstractBACKGROUND: We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes. METHODS: We searched MEDLINE (1966–2001), EMBASE (1980–2000), TOXLINE (1994–2000), EBM Cochrane Database of Systematic Reviews (1991–2000), Reproductive Toxicology (2001), teratology texts, and bibliographies of all the included studies. We looked for published randomized controlled studies reporting aspirin treatment to improve outcomes of moderate‐ and high‐risk pregnancies. The key words used to search for articles about exposure to aspirin were salicylic acid, pregnancy, and pregnancy complications; key words used to search for outcome were neonatal diseases and abnormalities. Based on our search strategy, 1904 citations were identified; their titles and abstracts were reviewed by one reviewer. Of these citations, 182 papers were selected for detailed review. Two reviewers independently determined whether a study should be included in the final analysis. In cases of disagreement, the decision was based on the assessment of a third reviewer. RESULTS: Data were extracted independently by each reviewer. We calculated the pooled relative risk (RR) or weighted mean difference and 95% confidence intervals (CI), assuming a random‐effect model. Thirty‐eight studies met the inclusion criteria. The risk for miscarriage did not differ between women treated with aspirin and placebo (seven studies; RR, 0.92; 95% CI, 0.71–119). Women who took aspirin had a significantly lower risk of preterm delivery than did those treated with placebo (22 studies; RR, 0.92; 95% CI, 0.86–0.98). There was no significant difference in perinatal mortality (20 studies; RR, 0.92; 95% CI, 0.81–1.05) and in the rate of small‐for‐gestational‐age infants (12 studies; RR, 0.96; 95% CI, 0.87–1.07) among offspring of mothers treated with aspirin and those of mothers treated with a placebo. CONCLUSION: For women with moderate‐ and high‐risk pregnancies, aspirin treatment seemed to have a small but significant effect on reducing the rate of preterm deliveries, but did not reduce the rate of perinatal death. Birth Defects Research (Part B) 68:70–84, 2003. © 2003 Wiley‐Liss, Inc.
Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development
Authors: Cappon G. D. , Gupta U. , Cook J. C. , Tassinari M. S. , Hurtt M. E. 
Published: April 2003

AbstractBACKGROUND: A review of the nonsteroidal anti‐inflammatory drug (NSAID) literature suggested occurrences of low‐level incidences of cardiovascular and midline defects in rabbit fetuses exposed in utero. Aspirin (acetylsalicylic acid, ASA) is a widely used NSAID that irreversibly inhibits cyclooxygenases (COXs) 1 and 2. ASA has been studied extensively in rats and has consistently increased low‐incidence cardiovascular malformations and defects in midline closure. The objectives of the current study were to comprehensively define the developmental toxicology profile of ASA in rabbits by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal gastrointestinal toxicity after repeated dose administrations hampers the detection of low‐incidence malformations with ASA in rabbits by limiting ASA administration to sensitive windows for cardiovascular development and midline closure. METHODS: ASA was administered to pregnant New Zealand White rabbits from gestation days (GDs) 7 to 19 at dose levels of 125, 250, and 350 mg/kg per day and as single doses of 500, 750, or 1000 mg/kg on GD 9, 10, or 11. Cesarean sections were performed on GD 29, and the fetuses were examined for external, visceral, and skeletal development. RESULTS: In the repeated dose study, maternal toxicity was exhibited in the 250‐ and 350‐mg/kg per day groups by mortality and decreased food consumption and body weight gain. In the single dose studies, maternal toxicity was exhibited at all doses by reductions in body weight gain and food consumption for 3 days after treatment. Fetal body weight was significantly reduced in the repeated dose study at 350 mg/kg per day. Fetal weights were not affected by single doses of ASA on GD 9, 10, or 11. There were no treatment‐related external, visceral, or skeletal malformations associated with ASA administration throughout organogenesis or with single doses administered during critical developmental windows. CONCLUSION: These findings supported previous work demonstrating that ASA is not teratogenic in rabbits, as opposed to rats, even when large doses are administered on single days during specific windows of development. Birth Defects Research (Part B) 68:38–46, 2003. © 2003 Wiley‐Liss, Inc.
Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms
Authors: Gupta Utpal , Cook Jon C. , Tassinari Melissa S. , Hurtt Mark E. 
Published: April 2003

AbstractBACKGROUND: Analysis of the literature for nonsteroidal anti‐inflammatory drugs (NSAIDs) suggests that a low incidence of developmental anomalies occurs in rats given NSAIDs on specific days during organogenesis. Aspirin (acetylsalicylic acid [ASA]), an irreversible cyclooxygenase 1 and 2 inhibitor, induces developmental anomalies when administered to Wistar rats on gestational day (GD) 9, 10, or 11 (Kimmel CA, Wilson JG, Schumacher HJ. Teratology 4:15–24, 1971). There are no published ASA studies using the multiple dosing paradigm of GDs 6 to 17. Objectives of the current study were to compare results between Sprague–Dawley (SD) and Wistar strains when ASA is administered on GD 9, 10, or 11; to compare the malformation patterns following single and multiple dosings during organogenesis in SD rats; and to test the hypothesis that maternal gastrointestinal toxicity confounds the detection of low incidence malformations with ASA when a multiple dosing paradigm is used. METHODS: ASA was administered as a single dose on GD 9 (0, 250, 500, or 625 mg/kg), 10 (0, 500, 625, or 750 mg/kg), or 11 (0, 500, 750, or 1000 mg/kg) and from GD 6 to GD 17 (0, 50, 125, or 250 mg/kg a day) in the multiple dose study to SD rats. Animals were killed on GD 21, and fetuses were examined viscerally. RESULTS: The literature evaluation suggested that NSAIDs induce ventricular septal defects (VSDs) and midline defects (MDs) in rats and diaphragmatic hernia (DH), MDs, and VSDs in rabbits (Cook JC et al., 2003); hence, the present study focused on these malformations, even though ASA induces several other low‐incidence malformations. In single dose studies, DH, MD, and VSD were induced on GDs 9 and 10. VSD also was noted following treatment on GD 11. In contrast, DH and MD were noted in the multiple dose study design only in the high‐dose group, and VSD was noted across all dose groups. CONCLUSIONS: High concordance in major developmental anomalies between Wistar and SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats. Variations and malformations were similar when ASA was administered as a single dose or during the period of organogenesis (GDs 6 to 17). It was also evident that, by titrating the dose to achieve a maximum tolerated dose, malformations that normally occur at low incidence, as reported from previous single dose studies, could also be induced with ASA given at multiple doses. Birth Defects Research (Part B) 68:27–37, 2003. © 2003 Wiley‐Liss, Inc.
Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure
Authors: Cappon G. D. , Cook J. C. , Hurtt M. E. 
Published: April 2003

AbstractBACKGROUND: A review of the scientific literature suggested the occurrence of low‐level incidences of ventricular septal defect (VSD) and midline defect (MD) in rat fetuses and diaphragmatic hernia (DH), VSD, and MD in rabbit fetuses after maternal exposure to nonsteroidal anti‐inflammatory drugs (NSAIDs). Aspirin, an NSAID that irreversibly inhibits cyclooxygenase 1 (COX‐1) and COX‐2, induces DH, VSD, and MD when administered as one dose during the sensitive periods of development in rats. Unlike aspirin, other NSAIDs, including selective COX‐2 inhibitors, reversibly inhibit COX activity. To evaluate whether the dysmorphogenesis observed after maternal NSAID exposure correlates with COX‐1 or COX‐2 inhibition, a series of compounds with different capacities to inhibit COX‐1 and COX‐2 were administered to pregnant rats and rabbits during the sensitive period for heart development and midline closure. METHODS: The compounds selected, ranked from the most COX‐2 selective to the most COX‐1 selective based on COX inhibition in a human whole blood assay, were CJ‐19,209, meloxicam, diclofenac, diflunisal, ibuprofen, and ketorolac. Rat dams were treated on gestation days (GDs) 9 and 10, and rabbit does were treated on GDs 9, 10, and 11. The doses selected for evaluation represented the maximum tolerable dose for the compound, with the exception of CJ‐19,209, which was dosed at 1000 mg/kg. Fetuses were collected by cesarean section on GDs 21 and 29 for rats and rabbits, respectively, and all fetuses were examined for external and visceral developmental anomalies. RESULTS: In rabbits, diflunisal induced DH, VSD, and MD (omphalocele) and single incidences of VSD and MD (gastroschisis) were noted in the ibuprofen group; no other developmental findings were associated with treatment. In rats, ibuprofen, diflunisal, and ketorolac induced increases in the incidence of VSD. In general, the induction of developmental defects was associated with compounds that selectively inhibit COX‐1 or have a high ratio of COX‐1 to COX‐2 inhibition. CONCLUSIONS: Inhibition of COX‐1 may be involved in the disruption of heart development, whereas the selective inhibition of COX‐2 (as assessed with CJ‐19,209) appears to have no effect on heart development and midline closure in rats and rabbits. Birth Defects Research (Part B) 68:47–56, 2003. © 2003 Wiley‐Liss, Inc.
Multidrug resistance proteins in rhabdomyosarcomas
Authors: Komdeur Rudy , Klunder Jenneke , van der Graaf Winette T. A. , van den Berg Eva , de Bont Eveline S. J. M. , Hoekstra Harald J. , Molenaar Willemina M. 
Published: April 2003

AbstractBACKGROUNDPediatric rhabdomyosarcomas (RMS) have a more advantageous prognosis after multimodality treatment compared with adult RMS, which might be related to a decreased sensitivity to chemotherapy in adults. Resistance to chemotherapy might be conveyed by the multidrug resistance (MDR)‐associated proteins P‐glycoprotein (P‐gp), multidrug resistance‐associated protein 1 (MRP1), and lung resistance‐related protein (LRP). It was therefore suggested that these proteins were expressed differently in pediatric and adult patients.METHODSThe expression of P‐gp, MRP1, and LRP was assessed immunohistochemically in 45 specimens of untreated RMS: 29 were obtained from children younger than 16 years old and 16 were obtained from adults. All children had an embryonal or botryoid RMS. Among the adults, there were 10 embryonal, 3 alveolar, and 3 pleomorphic RMS. Samples were scored as negative or positive according to the percentage of immunoreactive tumor cells: 0.5 (1–5%), 1 (5–25%), 2 (26–50%), 3 (51–75%), or 4 (> 75%).RESULTSExpression of LRP was more pronounced in embryonal and pleomorphic RMS in adults compared with RMS in children. In addition, LRP expression correlated with age at diagnosis. Alveolar RMS had remarkably low LRP expression. Expression of P‐gp and MRP1 did not differ significantly between children and adults.CONCLUSIONSIn this series of embryonal and pleomorphic RMS, an increased LRP expression was observed in adults, which may explain their worse response to chemotherapy reported in other studies. In alveolar RMS, a low LRP expression was observed, suggesting that other mechanisms are responsible for the resistant phenotype in most of these tumors. Cancer 2003;97:1999–2005. © 2003 American Cancer Society.DOI 10.1002/cncr.11259
Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma
Authors: Korones David N. , Benita‐Weiss Michal , Coyle Thomas E. , Mechtler Laszlo , Bushunow Peter , Evans Brandon , Reardon David A. , Quinn Jennifer A. , Friedman Henry 
Published: April 2003

AbstractBACKGROUNDAlthough temozolomide is active against recurrent malignant glioma, responses in many patients are modest and short‐lived. Temozolomide may prove more effective in combination with other agents. Therefore, combination oral chemotherapy for these patients is a particularly attractive approach.METHODSThe authors conducted a Phase I study of temozolomide in combination with escalating doses of oral etoposide (VP‐16) to determine the maximum tolerated doses of these two agents when given together. The temozolomide dose was fixed at 150 mg/m2 per day on Days 1–5. The oral VP‐16 was escalated in cohorts of 3 to 6 patients by numbers of days of VP‐16 administered: 50 mg/m2 per day, Days 1–5 (dose level 1), Days 1–8 (dose level 2), Days 1–12 (dose level 3), Days 1–16 (dose level 4), and Days 1–20 (dose level 5). Therapy was given in 28‐day cycles.RESULTSOf the 29 patients enrolled, 26 were fully evaluable and 3 were partially evaluable for toxicity. The 29 patients received a total of 92 cycles. The median age of the patients was 49 years (range, 28–76 years). Diagnoses included glioblastoma (n = 19), gliosarcoma (n = 3), anaplastic astrocytoma (n = 5), and anaplastic oligoastrocytoma (n = 2). The median time from diagnosis to disease recurrence was 8 months (3–188 months). Twenty patients were treated at the first disease recurrence, seven at the second, and two at the third. Twenty‐four patients (83%) were receiving anticonvulsants and 24 were receiving dexamethasone. All patients had received previous radiation, and 25 of 29 had been treated with chemotherapy previously. Of the 3 patients at dose level 1, none had dose‐limiting toxicity (DLT). Of the 6 patients at dose level 2, 1 patient had DLT: Grade 3 thrombocytopenia resulting in a > 2‐week delay in starting the next cycle of chemotherapy. Of the 6 patients at dose level 3, 1 patient had DLT: death due to pneumonia. There were 2 DLTs in the 7 patients at dose level 4: fever, neutropenia, and herpes zoster infection in 1 patient and death due to pneumonia in another. Seven patients had been started at dose level 5 when DLT was established at dose level 4: of the 5 fully evaluable and 2 partially evaluable patients at dose level 5, there was no DLT.CONCLUSIONSThe maximum tolerated dose of temozolomide and oral VP‐16 in this heavily treated group of patients with recurrent malignant glioma is temozolomide 150 mg/m2 per day for 5 days and oral VP‐16 50 mg/m2 per day for 12 days. Cancer 2003;97:1963–8. © 2003 American Cancer Society.DOI 10.1002/cncr.11260