bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome profiling reveals cuproptosis heterogeneity in triple-negative breast cancer
Authors: Song Xiao-Qing , Jiang Jun-Han , Sui Xin-Yi , Shao Zhi-Ming 
Published: December 2023

Abstract
Objective
Breast cancer has various subtypes, among which triple-negative breast cancer (TNBC) stands out as the most malignant and heterogeneous form and has a poor prognosis. One area of focus is the phenomenon known as cuproptosis, which represents a recently identified and regulated type of cell death. Unlike previously recognized mechanisms, cuproptosis is characterized by its reliance on both copper and mitochondrial respiration. The relationship between TNBC and cuproptosis remains to be elucidated.
Methods
We obtained RNA-seq and clinical data form Fudan University Shanghai Cancer Center (FUSCC) and The Cancer Genome Atlas (TCGA) TNBC cohort. We conducted K-means cluster analysis of TNBC based on the expression of 13 cuproptosis regulators (DLAT, DLD, FDX1, LIAS, LIPT1, PDHA1, PDHB, ATP7B, ATP7A, DLST, SLC31A1, DBT and GCSH). Kaplan-Meier survival analysis was performed to determine the survival difference among different clusters. To examine the sensitivity to cuproptosis inducer, cell viability assays was performed in TNBC cell lines with different ATP7B protein expression. Cox and least absolute shrinkage and selection operator (LASSO) regression analyses were used to construct cuproptosis-associated risk score. Receiver operating characteristic (ROC) and calibration curves were used to evaluated the performance of risk score.
Results
We classified TNBC into four clusters. Compared with other clusters, cluster 1 exhibited high ATPase copper transporting beta (ATP7B) expression, low immune infiltrate and poor prognosis. Through subsequent experimental validation, we demonstrated ATP7B as a crucial cuproptosis regulator, TNBC cells with low ATP7B expression or ATP7B knockdown indicated drug-sensitive to cuproptosis inducer. In addition, we constructed and validated a cuproptosis-associated signature of 11 genes (CFAP44, HLA-C, PLA2G16, RDH10, GPC4, NEBL, NCAM2, MKL2, TRIQK, ATP7B and TMEM178). The 1-year, 3-year, and 5-year area under the ROC curve (AUC) in the training cohort were 0.69, 0.80, and 0.76, while in test cohort were 0.91, 0.85, and 0.82. The results suggested our cuproptosis-associated signature could accurately predict the progonosis for TNBC patients.
Conclusion
Our results provide new insights into heterogeneous phenotypes in cuproptosis for TNBC, and may inspire new approaches for TNBC treatment.
Potential Impacts of Forest Wildfires on Regional Water Quality: A Case Study of the "8·19" Forest Fire in Jiangjin, Chongqing
Authors: Hu Qixin , Zhang Lei , He Chao 
Published: December 2023

Abstract

In the evolving backdrop of anthropogenic climate change, forest wildfires have increasingly raised concerns due to their pronounced adverse impacts on regional water quality. These events could emerge as pivotal determinants in future water quality degradation trajectories. Building upon the outlined concerns regarding forest wildfires and their subsequent impact on water quality, this study embarks on a comprehensive exploration of such intricate relationships, using the Chongqing "8·19" forest fire as a representative case. Through leveraging regional water quality monitoring data, real-time meteorological surveillance data, and atmospheric pollutant concentration data (black carbon and organic matter), an integrative methodological approach is employed. This approach synergistically combines spatial statistics, buffer zone analysis, airflow trajectory analysis, and potential source apportionment models to holistically scrutinize this multifaceted relationship. Navigating through the ramifications of wildfires, notably exemplified by the Chongqing "8·19" forest fire, this study meticulously outlines the conspicuous impacts on regional water quality, unraveling pathways not solely confined to direct ash deposition but also intertwined with indirect interactions of atmospheric pollutants. Post-wildfire, an explicit diminution was documented in stations classified as Class III and above on the Water Quality Index (WQI), concurrently witnessing a sharp incline in Total Nitrogen and turbidity levels during August and September, reaching peaks at 3.33 mg/L and 111.7 NTU, respectively. Moreover, an alignment was discerned between the northern and northwestern particulate pollutant migration—subsequent to the fire—and areas recording elevated atmospheric Black Carbon and Organic Matter concentrations, concomitant with the principal zones of water quality impairment. This research unveils a complex, multifaceted conduit of wildfire repercussions on water quality, spotlighting an imperative for integrative future inquiries that encapsulate both the direct and indirect consequences of biomass burning. Such investigations propel us toward formulating comprehensive, actionable watershed management strategies, particularly crucial amidst escalating anthropogenic climate alterations.
Evaluation of Predictors of Ineffectiveness of Antiviral Therapy for Chronic Hepatitis C in the Republic of Kazakhstan
Authors: Maikenova Arailym , Nersesov Alexander , Kuantay Elmira , Kulimbet Mukhtar , Yerlanova Yerkezhan , Colombo Massimo Giuseppe , Pavlov Chavdar , Jumabayeva Almagul , Nugmanova Balzhan , Ayupova Venera , Yarunina Raissa , Kaulybekova Assel , Alimkhan Ulzhalgas , Churukova Nazugum , Kaltayev Ilyas , Alpysbayeva Gulnar , Atasheva Roza , Balabek Aliya , Kassymova Tatyana , Kurmangazin Meirambek , Kyzdarbekov Askar , Mukanova Gulnara , Nurpeisova Aiman , Sapargaliyeva Nazigul , Shamsivaliyeva Kunsulu , Zhumatayeva Saule , Ligay Yuliya 
Published: December 2023

Abstract
This study aims to identify the predictors of ineffectiveness in antiviral therapy for chronic hepatitis C (CHC) in Kazakhstan. The rising prevalence and mortality rates associated with CHC globally and within Kazakhstan underscore the need for effective antiviral treatment strategies. Despite the introduction of direct-acting antiviral agents (DAAs) with high cure rates, a subset of patients fails to achieve a sustained virological response (SVR). We conducted a multicenter retrospective matched case-control study across 13 regions of Kazakhstan, including 812 patients with CHC. The study involved patients registered in healthcare organizations who had received DAAs, focusing on those who did not reach SVR. Variables such as demographic characteristics, virological status, stage of liver disease, comorbidities, lifestyle factors, therapy regimen, and patient adherence were analyzed. Logistic regression analysis identified multiple factors associated with increased risk of non-response to therapy, including comorbid conditions like arterial hypertension, hepatocellular carcinoma, and lifestyle factors. The study highlights the complexity of CHC treatment in Kazakhstan, emphasizing the need for personalized treatment plans and addressing comorbid conditions and lifestyle factors. This research contributes to understanding the multifaceted nature of CHC treatment response and aids in optimizing therapeutic strategies in similar healthcare settings.
Considering inequities in national dementia strategies: Breadth, depth, and scope
Authors: Godard-Sebillotte Claire , Navani Sanjna , Vedel Isabelle 
Published: December 2023

Abstract
Background: In response to the World Health Organisation’s call to address dementia as a public health priority, several countries have developed national dementia strategies. These strategies aim to improve the care, support, and resources available to meet the needs of persons living with dementia and their care partners and communities. Despite the known impact of social determinants of health on dementia risk, care, and outcomes, it is unclear whether dementia strategies adequately address related inequities. This study aimed to describe whether and how national dementia strategies considered inequities associated with social determinants of health.
Methods: We conducted an environmental scan of the national dementia strategies of countries that are part of the Organisation for Economic Cooperation and Development (OECD). Included strategies had to be accessible in English or French. Sub-national or provincial plans were excluded. We synthesised information on strategies' considerations of inequity through a thematic analysis.
Results: Of the 15 dementia strategies that met inclusion criteria, 13 mentioned at least one inequity (M=2.4, median=2, range:0-7) related to Race/Ethnicity; Religion; Age; Disability; Sexual Orientation/Gender Identity; Social Class; or Rurality. Age and disability were mentioned most frequently, and religion most infrequently. 11 strategies included general inequity-focused objectives, while only 5 had specific inequity-focused objectives in the form of tangible percentage changes, deadlines, or allocated budgets for achieving equity-related goals outlined in their strategies.
Conclusions: Understanding if and how countries consider inequities in their dementia strategies enables the development of future strategies that adequately target inequities of concern. While most of the strategies mentioned inequities, few included tangible objectives to reduce them. Countries must not only consider inequities at a surface-level; rather, they must put forth actionable objectives that intend to lessen the impact of inequities in the care of all persons living with dementia.
Nutritional Support and Prevention of Complications in Treatment Contribute to Improved Prognosis in Pediatric Diffuse Intrinsic Pontine Glioma Patients
Authors: Huang Jianhua , Zhang Ruihua , Zhao Li , Yang Chunxia , Ma Lijuan , Ren Chi , Zhang Hongwei 
Published: December 2023

Abstract
Background
Diffuse intrinsic pontine glioma (DIPG), a malignant brain tumor in children, lacks effective treatment options, often presents with multiple complications during treatment, and has a poor prognosis.
Objective
To define the correlation between nutritional status, complications, and prognosis in pediatric patients with DIPG.
Methods
Clinical data were retrieved from the hospital database and follow-up, and the following clinical data of patients were organized and analyzed: age, gender, Karnofsky performance status (KPS) score at admission, treatment received, occurrence of pneumonia, onset of bed rest, overall survival (OS), 12-month survival rate, time to progression, occurrence of venous thrombosis, and prognostic nutritional index (PNI) at three stages after onset, within one week after radiotherapy, and in the last follow-up.
Results
A total of 34 patients met the inclusion criteria from January 2017 to June 2022. The average age was 9.0 years, and 47.1% were female. The median KPS score was 70 at admission. 29.4% of the patients were definitively diagnosed with pneumonia during the treatment of the disease, 32.4% had upper extremity venous thrombosis, and 29.4% had lower extremity venous thrombosis. The median OS of the patients was 9.2 months, and the median progression time was 4.7 months. The PNI was correlated at three stages, and it was the highest after radiotherapy (43.6 ± 8.2). Through COX survival analysis, we found that the occurrence of venous thrombosis was a disadvantageous factor for patient prognosis. The prolongation of the median progression time and the increase of the PNI at the three stages were positively correlated with the good prognosis of the patients.
Conclusion
High PNI sore and prevention of complications exert positive role in the prognosis of DIPG patients.
Increasing global land surface soil organic carbon under climate change
Authors: Liu Yanli , Chen Xin , Zhang Jianyun , Yuan Xing , Guan Tiesheng , Jin Junliang , Wang Guoqing 
Published: December 2023

Abstract
Soil organic carbon (SOC), especially land surface SOC is sensitive to climate change as a sink or source of atmospheric carbon dioxide, which is an important component of the global carbon cycle and could play a key role in global carbon neutrality. However, it is still an open question about how global surface SOC change with climate warming. Here we show global SOC has a significant upward trend during 1981-2019. Temperature and precipitation are the dominant climate drivers at global scale, but vegetation cover is a crucial local factor. By integrating with climate scenarios of CMIP6 models, we project the future increase in global surface SOC with warming temperature, especially in middle and low latitudes. SOC change shows a lag feedback and limited balance role depending on the regional vegetation changes. Under 1.5oC global warming level, land carbon sink from SOC will maximally increase by 13.0 PgC from SSP2-4.5, but it only accounts for 19% of carbon emission capacity from current 1.1 to 1.5 oC global warming level. It is far from the Paris Agreement plan of four out of one thousand soil carbon stock of 40cm below the surface increase per year in the next 20 years (2.72 PgC yr-1). Moreover, this contribution is full of uncertainties and confined to support large-scale carbon dioxide removal from the atmosphere. Over-reliance on natural carbon sinks is a risky strategy. These findings highlight the urgency to carry out mitigation and removal strategies of reducing greenhouse gas emissions for the global carbon equilibrium and the Paris Agreement target.
Investigation into the relationship between Parallel Visual Task Processing Ability and Academic Performance in School-Age Children
Authors: Tian Yu-Jing , Chen Chen , Zhang Xiao-Han , Cao Yu-Juan , Yu Ying-Qing 
Published: December 2023

Abstract
Background
This study explores the relationship between parallel visual task processing ability and academic performance in school-age children at a primary school in Wuxi City.
Methods
A total of 1044 school-age children from grades 1 to 6 in a Wuxi City primary school were selected as the research subjects. Eye position was assessed using the alternate cover test, and the Visual Perception Assessment System was used to evaluate cursor visual acuity, simultaneous vision, fusion vision, and stereoscopic vision under competitive conditions. The relationship between various parallel visual task performances and academic performance was studied using Spearman correlation analysis and Mann-Whitney U test.
Results
There is a positive correlation between competitive stereoscopic vision function and Chinese language performance (r = 0.073, P = 0.019). The median standardized Chinese language scores for the competitive stereoscopic vision detection score group and the non-score group were 0.29 and 0.19, respectively, and the difference between the two groups was statistically significant (U = 123007, Z=-2.491, P = 0.013).
Conclusion
Specific parallel visual task processing abilities in school-age children are related to Chinese language performance. These findings can provide appropriate assessment methods for individuals affected by visual problems, reducing the risk of visual issues affecting learning.
Trail registration:
Ethics Committee of Affiliated Children’s Hospital of Jiangnan University
CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence In-Situ Hybridization
Authors: Ranade Manali , Epari Sridhar , Shetty Omshree , Dhanavade Sandeep , Chavan Sheetal , Sahay Ayushi , Sahu Arpita , Shetty Prakash , Moiyadi Aliasgar , Singh Vikash , Dasgupta Archya , Chatterjee Abhishek , Kannan Sadhana , Gupta Tejpal 
Published: December 2023

Abstract
Introduction: CDKN2A/B homozygous-deletion is one of the defining features of grade 4 in IDH-mutant astrocytic tumours. Aim: To evaluate CDKN2A/B-deletion in IDH-mutant astrocytic tumours and its clinico-pathological impact. Materials and methods: CDKN2A/B-deletion was evaluated by Fluorescence in-situ hybridisation (FISH) and interpreted by Ambros et al. (method 1) and Marker et al. (method 2) methods. Results: Eighty-three out of 94 cases (histologically - grade 2: 3, grade 3: 46, grade 4: 34) were interpretable on FISH. Concordant CDKN2A/B-deletion was observed in 71% (27/38) of lower-grade tumours (n = 49) and 90% (27/30) of histological grade 4 tumours. Both the interpretation methods showed good agreement (Kappa = 0.75). CDKN2A/B-deletion showed inverse correlation for < 10% MIB-1 labeling index (p = 0.01) while by method-2 showed significant correlation for grade 4 (p = 0.02). No significant correlation was observed for any other clinico-pathological parameters. Twenty-four patients showed progression/recurrence (including deaths), no significant difference in frequency of CDKN2A/B deletion was observed among cases with disease progression across different histological grades. Conclusions: CDKN2A/B-deletion was observed across all the histological grades of IDH-mutant astrocytic tumours, expectedly more in higher grade. FISH, as a method can be used for detection of CDKN2A/B homozygous-deletion, when there is concordant interpretation.
Perioperative Outcome and its Determinants among Patients with Perforated Peptic Ulcer Disease in Debre Berhan Comprehensive Specialized Hospital: Three Years Retrospective Cross-Sectional Study
Authors: Deresse Tilahun , Kifleyohans Tewodros , Dessalegn Megbar , Eskandar George 
Published: December 2023

Abstract
Background
PUD is associated with potentially life-threatening complications, including bleeding, perforation, penetration, and obstruction. Perforation is the second most frequent complication after bleeding and with significant morbidity and mortality.
Methodology: A retrospective study was conducted by revising patient card registry data from January 2018 to December 2020 at DBCSH, and data was collected using a data extracting checklist. Logistic regression was conducted to assess the association between dependent and independent variables. Adjusted odd ratios with 95% CI and P-value<0.05 were used as significant associations between dependent and independent variables.
Result: Among 102 patients who were operated on during the specified period, 94 were enrolled in the study after the exclusion of 8 patients, whose charts were missing relevant information. Males outnumbered females with a ratio of 3.7:1. The mean age of patients was 37.39 ± 15.45. More than half, 56.4% of them presented late, greater than 24 hours from their initial symptoms. A total of 52 complications in 27(28.7%) patients were found. Advanced age of patients, tachycardia, and delayed presentation were found to have statistically significant associations with the development of postoperative complications (p-value < 0.05). On multivariate analysis, only age (AOR =3.56, CI=1.21, 10.45) and pre-operative stay (AOR= 3.71, CI= 1.18, 11.65) were found to have statistically significant associations (p-value <0.05) with postoperative morbidity. The post-operative hospital stay of patients with complications was significantly high as compared to those patients who didn’t develop complications (p, 0.000).
Conclusion: Advanced age of patients, tachycardia, and delayed presentation, were significantly associated with the development of post-operative complications.
Paulo Freire in worldwide science education: an overview
Authors: Marcelino Leonardo Victor , Gehlen Simoni Tormöhlen 
Published: December 2023

Abstract
Paulo Freire’s works are among the most cited books in Social Science research and the most influential philosopher in critical curriculum studies. However, Freire himself often felt misunderstood, reduced to only a few of his concepts or to a method, being criticized by his oversight of racial matters, sexist language and utilitarian view of environment. Recognizing the diverse interpretations of Freire's work can provide researchers and practitioners with alternatives for addressing contemporary issues in science education. Given the critical role of academic publications in advancing science and the importance of coauthorship in shaping research and researcher identities, this paper proposes bibliometric tools for investigating how Paulo Freire's ideas have been appropriated into science education, seeking to elucidate the composition of coauthorship groups, the patterns of their interactions, and the ways in which they incorporate Freire's works into their research. Twenty-seven groups with at least three papers and two authors are found, of which 14 make perfunctory references to Freire’s works. Brazil and USA are the most prolific countries in the field, no African research is found, and few interactions are held between Latin American nations. Clusters that make significant references to Freire addresses thematic investigation and reflective practices, mainly in teacher education; racial issues, power imbalance, and STS and SSI approaches are also related to Freirean science education. In conclusion, more interaction between clusters can develop the field theoretically and methodologically; also, there is need for reflecting on science education research in Latin America and Africa, and the possibilities of this cooperation.
Investigation of photocatalytic activity of nickel-doped manganese aluminum ferrite nanoparticles for rhodamine b degradation under visible light
Authors: Yasar Muhammad 
Published: December 2023

Abstract
Nickel-doped manganese aluminum ferrite NiXMn1−XAl0.5Fe1.5O4 (X = 0,0.3) nanoparticles were synthesized via the Sol-gel method. XRD showed the spinel ferrite structure with average crystallite sizes of 30.66 to 39.69 nm. FTIR confirmed metal-oxygen bonds. SEM revealed the surface morphology and particle sizes of 75–95 nm. EDX confirmed the elemental composition. BET analysis determined the surface area of 13.43 m2/g for undoped and 28.38 m2/g for Ni-doped ferrite. The band gap decreases from 2.4 to 2.2 by doping nickel. Achieving 98.96% degradation of 10 mg/L Rhodamine B within 120 min under visible light irradiation was accomplished using a catalyst dose of 0.1 g/L at pH 7 and 20°C with a light intensity of 100 W. The photodegradation kinetics followed a first-order reaction. Hydroxyl radicals were identified as the major reactive species responsible for dye degradation. The nickel-doped ferrite nanoparticles exhibited efficient and stable photocatalytic performance for Rhodamine B removal from wastewater under visible light. Photocatalytic performance for Rhodamine B removal from wastewater under visible light.