bluuebunny/crossref_metadata_2025_split huggingface dataset:
MIXED MÜLLERIAN TUMOUR OF THE CORPUS UTERI
Authors: Hayes Dorothy 
Published: August 2005

SummaryThe pathology, behavioural pattern and malignancy of 35 mixed Müllerian tumours of the corpus uteri are reviewed. Patients with this tumour had a five‐year survival of 23 per cent. Late recurrence and metastases were unusual and the mortality from the tumour tended to be non‐progressive. The most important prognostic factor was the extent of tumour spread at the time of diagnosis. Separation into carcinosarcoma and mixed mesodermal tumour conferred no clinical advantage and the presence of heterotopic tissue was of no prognostic significance.
THE USE OF RITODRINE IN THE TREATMENT OF PREMATURE LABOUR
Authors: Renaud R. , Irrmann M. , Gandar R. , Flynn M. J. 
Published: August 2005

SummaryA series of 64 patients with threatened premature labour and intact membranes were treated with ritodrine by the intravenous, intramuscular and oral routes. It was possible to stop labour for 24 hours or more in 87 per cent of the patients and for more than one week in 80 per cent of the patients. The fetus was delivered after 36 weeks in 73 per cent of patients in whom the intention was to postpone labour till term.
A CRITICAL EVALUATION OF RENAL PROTEIN SELECTIVITY IN PREGNANCY
Authors: Simanowitz M. D. , MacGregor W. G. 
Published: August 2005

SummaryRenal protein selectivity has been examined as a diagnostic and prognostic index in pregnancy. No correlation was found between selectivity and renal function or fetal prognosis. Differences were noted between selectivity in patients with preeclampsia and those with essential hypertension in pregnancy, but the degree of overlap was too great to suggest that selectivity would be a clinical measurement of use as a guide to the management of pregnancy complicated by hypertension.
ADRENOCORTICOTROPHIC HORMONE IN PLASMA OF MOTHER AND NEWBORN
Authors: Dokumov Stoyan I. , Milanov Stefan C. , Trepetshov Stefan P. 
Published: August 2005

SummaryPlasma adrenocorticotrophic hormone (ACTH) was assayed by the radioimmunological method of Berson and Yalow (1968) in 60 mothers and their newborn infants. Twenty healthy, nonpregnant women were also investigated and their plasma ACTH concentrations were lower than those in pregnant women. The plasma ACTH level of the newborn was about half that in healthy, non‐pregnant women and much lower than that in patients in labour. These results suggest that maternal ACTH did not cross the placental barrier and that the development and function of the fetal adrenal cortex depended on stimulation by ACTH from the fetal, and not the maternal, pituitary.
RUPTURE OF THE CERVIX IN PROSTAGLANDIN ABORTIONS
Authors: Kajanoja P. , Jungner G. , Widholm O. , Karjalainen O. , Seppälä M. 
Published: August 2005

SummaryA total of 412 patients had second trimester abortions and in five of them a rupture of the cervix was detected. An attempt is made to relate the occurrence of this complication to age, parity and to the method of stimulating uterine activity.
PELVIC PERITONEAL OXYURIASIS SIMULATING METASTATIC CARCINOMA A CASE REPORT
Authors: FitzGerald T. B. , Mainwaring A. R. , Ahmed Ali 
Published: August 2005

SummaryA patient is reported who had pelvic peiitoneal oxyuriasis which came to light while investigating symptoms and signs which were not regarded as being primarily due to the parasite.
FACTORS INFLUENCING THE MEASUREMENT OF THE LECITHIN/SPHINGOMYELIN RATIO IN AMNIOTIC FLUID
Authors: Wagstaff T. I. , Whyley G. A. , Freedman G. 
Published: August 2005

SummaryThe estimation of the lecithin/sphingomyelin (L/S) ratio of amniotic fluid is a valuable aid in determining the optimum time for delivery in complicated pregnancies. The method of Borer and Gluck (1971) has been widely adopted because of its simplicity, the use of commercial chromatogram material, and the need for only small quantities of amniotic fluid. While the actual values reported originally have usually been adopted in clinical management, the technique has frequently been modified by following workers in ways that may radically alter the final result. The effects on the L/S ratio and the physical determination of surfactant of changes in the method and the presence in the amniotic fluid of chemical or biological contaminants have been measured and assessed.
VIBRATION OF THE CERVIX IN LABOUR
Authors: Brant H. A. , Lachelin Gillian C. L. 
Published: August 2005

SummaryThe experience gained in using the cervical vibrator therapeutically in 250 labours is reviewed. The instrument is considered to be a valuable additional aid for expediting labour in appropriate circumstances, and for facilitating the taking of fetal scalp blood samples. The follow‐up of 33 patients who have had 36 subsequent pregnancies has not revealed any abnormality attributable to cervical vibration in the earlier pregnancy.
THE OUTCOME OF PREGNANCY AFTER FAILURE OF AN INTRAUTERINE CONTRACEPTIVE DEVICE
Authors: Steven J. D. , Fraser I. S. 
Published: August 2005

SummaryThe outcome of 82 pregnancies associated with failure of an intrauterine device is reported. Four of the pregnancies were extrauterine, and 31 per cent of the 78 intrauterine pregnancies were legally terminated. Spontaneous or missed abortion occurred in 57 per cent of the remainder and over half of these abortions were in the second trimester. Threatened abortion, antepartum haemorrhage and manual removal of an adherent placenta were encountered more frequently than expected. One neonatal death due to prematurity was recorded, and there was one congenital fetal abnormality.
MATERNAL SERUM, AMNIOTIC FLUID AND CORD SERUM SEROMUCOID IN NORMAL AND COMPLICATED PREGNANCY
Authors: Good W. , Randle G. H. , Cumberbatch K. N. 
Published: August 2005

SummaryA study was made of seromucoid in pregnancy, both in the absence and in the presence of complicating factors. Maternal serum seromucoid was raised in normal pregnancy and was significantly higher in primiparae than in multiparae. The seromucoid levels of amniotic fluid and cord serum were both about half the maternal value and were not affected by parity. In complicated pregnancies the maternal serum, amniotic fluid and cord levels of seromucoid were mainly normal, but the maternal serum level was significantly raised in essential hypertension and pre‐eclamptic toxaemia.
INDUCTION OF LABOUR WITH PROSTAGLANDIN E2 TABLETS
Authors: Thiery M. , Le Sian A. Yo , Hemptinne D. de , Derom R. , Martens G. , Van Kets H. , Amy J. J. 
Published: August 2005

SummaryPGE2 tablets were administered for induction of labour to 47 clinically normal patients at term who, one hour after amniotomy, had less than 100 Montevideo Units of uterine activity. The dosage of PGE2 was individually adjusted and never exceeded 2.0 mg. two‐hourly. One multiparous patient was given oxytocin for acceleration of labour. The other 46 patients required no other oxytocic drugs.
THE SELECTIVE UPTAKE OF TAMOXIFEN BY HUMAN UTERINE TISSUE
Authors: Fromson J. M. , Sharp D. S. 
Published: August 2005

SummaryA series of patients who were suffering from dysfunctional uterine bleeding (menorrhagia) were dosed with [14C] tamoxifen prior to hysterectomy being performed. The proportion of the labelled dose which became bound to the various tissues of the uterus at different stages of the menstrual cycle was investigated. There was no apparent variation in the uptake of the compound during the menstrual cycle. However, it was found that the levels of radioactivity in the uterine tissues examined were higher than those found in the serum and that the proportion of radioactivity representing unchanged drug was two to three times that found in the serum. It appeared that tamoxifen had a definite affinity for the endometrium and that there was also some selective uptake by the corpus luteum.
A NEW “COLD COAGULATOR” FOR USE IN THE OUTPATIENT TREATMENT OF CERVICAL EROSION
Authors: Fergusson I. L. C. , Craft I. L. 
Published: August 2005

SummaryA new method of low heat electrocautery (cold coagulation) treatment of cervical erosion has been assessed. It has the advantages of being odourless, smokeless and relatively pain free when compared with hot wire cautery or diathermy treatment. It has been found to compare favourably with a matched series of patients treated by cryosurgery.
FETAL HEART RATE DURING LATE PREGNANCY
Authors: Wheeler Timothy , Guerard Patricia 
Published: August 2005

SummaryContinuous records of fetal heart rate were made weekly during the last trimester of 15 normal pregnancies. Using an ultrasonic technique, a total of 124 records, each lasting 50 minutes, was obtained. With increasing length of gestation there was a small but significant reduction in mean heart rate and an increase in beat‐to‐beat variation. On some occasions, two distinct patterns of beat‐to‐beat variation could be distinguished in the same record. These appeared to be related to fetal movement.
THE DIAGNOSIS OF RUPTURED FETAL MEMBRANES BY MEASUREMENT OF THE DIAM1NE OXIDASE (DAO) ACTIVITY IN VAGINAL FLUID
Authors: Elmfors Bengt , Tryding Nils , Tufvesson Göran 
Published: August 2005

SummaryAmniotic fluid contains diamine oxidase (DAO) in high concentration, almost equal to that in maternal blood plasma (Törnqvist et. al, 1971). After rupture of the membranes the enzyme is demonstrable in the vagina and in the absence of vaginal bleeding the measurement of the DAO content of vaginal fluid has been shown to be a reliable method of resolving doubt about whether or not the membranes have ruptured.
HUMAN CHORIONIC GONADOTROPHIN LEVELS DURING AND AFTER LABOUR
Authors: Macdonald H. N. , Buckler J. M. H. , Scott J. S. 
Published: August 2005

SummaryUsing a radioimmunoassay, plasma human chorionic gonadotrophin (HCG) levels were measured sequentially during labour and after delivery. After placental expulsion, the HCG levels dropped rapidly at first and then more slowly. The findings are discussed in relation to theories about the aetiology of pre‐eclampsia and eclampsia and the degradation of HCG.
ISOELECTRIC FOCUSING PATTERNS OF AMNIOTIC FLUID PROTEINS IN PREGNANCY COMPLICATED BY RHESUS ISOIMMUNIZATION
Authors: Dale G. , Oxley A. , Walker W. 
Published: August 2005

SummaryThe technique of isoelectric focusing in polyacrylamide gel was used to investigate the protein patterns of amniotic fluid obtained from women with rhesus isoimmunization. There were no specific changes in protein pattern which could be related to the severity of haemolytic disease. Qualitative changes in the electrophoretic mobility of transferrin were demonstrated. Serial investigations showed that these changes were related to gestational age and were probably a feature of normal pregnancy. The phenomenon appears to be due to alteration in the sialic acid content of the transferrin, presumably the result of alteration in neuraminidase activity.
CHANGES IN RENAL WATER AND ELECTROLYTE EXCRETION OCCURRING BEFORE AND AFTER INDUCED OVULATION AND THEIR RELATION TO TOTAL OESTROGEN AND PREGNANEDIOL EXCRETION
Authors: Parboosingh J. , Doig A. , Michie E. A. 
Published: August 2005

SummaryOvulation was induced by gonadotrophin therapy in eight women with secondary amenorrhoea. During ovarian inactivity and throughout the preovulatory and luteal phases of the induced cycles continuous measurements were made of mean urine flow and the urinary excretion of total solute, sodium, potassium, urea, total oestrogens and pregnanediol. The preovulatory rise in total oestrogen excretion was associated with a reduction in sodium output whereas the excretion of greatly increased amounts of pregnanediol after ovulation was associated with an increase in sodium excretion. Maximal pregnanediol excretion tended to coincide with a second peak in total oestrogen excretion but was unaccompanied by any further rise in sodium output. Night sodium excretion was disproportionately increased after ovulation and was associated with an increment in night potassium excretion. Alterations observed in total solute excretion and urine flow were mainly determined by changes in sodium excretion.
ALPHA‐FETOPROTEIN LEVELS IN AMNIOTIC FLUID IN PREGNANCIES COMPLICATED BY RHESUS ISOIMMUNIZATION
Authors: Whyley G. A. , Ward Humphry , Hardy N. R. 
Published: August 2005

SummaryAlpha‐fetoprotein (AFP) has been estimated in 249 samples of amniotic fluid from 71 patients, 60 of whom had rhesus isoimmunization. No difference was found between the AFP levels in unaffected pregnancies, pregnancies complicated by mild or moderate disease or in severe rhesus isoimmunization when the baby survived. However, in the severe group with an unfavourable fetal outcome, 42 per cent of the cases had amniotic fluid levels of AFP which were above 5.5 mg. /ml. on one or more occasions. In the most severely affected cases a correlation existed between the amniotic fluid AFP levels and both the optical density difference (Δ) at 450 mμ and protein concentration in the liquor amnii. Erroneously elevated amniotic fluid levels of AFP may be found when the fluid has been contaminated by ascitic fluid or fetal blood. It is suggested that the level of AFP in amniotic fluid taken in conjunction with the Δ 450 mμ, peak might be a valuable guide in identifying the severely affected pregnancy in which the fetal prognosis is grave.
HISTOCHEMICAL EXAMINATION OF THE HUMAN PLACENTA FOR 5‐HYDROXYTRYPTAMINE AND MONOAMINE OXIDASE
Authors: Jones J. B. , Madill G. T. , Pryse‐Davies J. 
Published: August 2005

SummaryHuman placentas of varying gestational age (19 to 40 weeks) have been examined histochemically using techniques which in other tissues have demonstrated 5‐hydroxytryptamine (5‐HT) and monoamine oxidase (MAO). Failure to identify 5‐HT strengthens an earlier opinion that the human placenta is incapable of producing this pressor amine. MAO was demonstrated in the syncytiotrophoblast and cytotrophoblast. It is suggested that MAO protects the placental vasculature from 5‐HT produced by the developing fetus. Alteration in progesterone concentration may affect the equilibrium.
SEROMUCOID IN SERUM IN BENIGN AND MALIGNANT GYNAECOLOGICAL DISORDERS
Authors: Randle G. H. , Good W. , Cumberbatch K. N. 
Published: August 2005

SummaryThe serum levels of seromucoid were examined in patients with a wide variety of benign and malignant gynaecological disorders. Seromucoid was unchanged from normal in most benign conditions, but it was raised in pelvic infection and tended to be low in infertility. Serum seromucoid was unchanged in patients with carcinoma in situ, but was increased substantially above normal with invasive cancer. The level of serum seromucoid in patients with cancer was related to the severity of the clinical lesion and returned to normal when the lesion was successfully treated. Cases of recurrent carcinoma had highly elevated serum seromucoid levels. The measurement of serum seromucoid levels may be a useful means of assessing the severity of cancer and monitoring the effectiveness of its treatment.
A COMPARISON OF LOW‐DOSE SUBCUTANEOUS HEPARIN AND INTRAVENOUS DEXTRAN 70 IN THE PROPHYLAXIS OF DEEP VENOUS THROMBOSIS AFTER GYNAECOLOGICAL SURGERY
Authors: McCarthy T. G. , McQueen J. , Johnstone F. D. , Weston J. , Campbell S. 
Published: August 2005

SummaryIn a prospective randomized trial, 132 patients were treated with subcutaneous heparin or intravenous dextran 70 in the prevention of deep vein thrombosis after gynaecological surgery. The two groups were evenly matched for factors predis‐posing to deep vein thrombosis. The incidence of deep vein thrombosis as detected by the 125I‐labelIed fibrinogen test was 10.9 per cent in the heparin‐treated group and 16.2 per cent in the dextran‐treated group; this difference was not significant. Two patients with complicated postoperative courses, one in each treatment group, developed pulmonary emboli. Only one had a positive 125I‐labelled fibrino‐gen test. Both prophylactic regimes were successful in reducing the incidence of minor thrombosis in the legs but may not reduce the incidence of pulmonary embolism.
RUPTURED ECTOPIC PREGNANCY 31 DAYS AFTER LAPAROSCOPIC STERILIZATION
Authors: Amin H. K. 
Published: August 2005

SummaryA case of fimbrial ectopic pregnancy occurring 31 days after laparoscopic sterili‐zation is reported. It is thought that the fertilized ovum must have implanted a day or two before sterilization and that it was neither detected nor disturbed by the operative procedure. The importance of carrying out sterilization in the preovulatory phase of the menstrual cycle is stressed.
HYPERTENSION IN PREGNANCY
Authors: Scanlon Maurice F. 
Published: August 2005

SummaryPossible aortic compression by the gravid uterus has been examined by comparing arm and leg blood pressures of women in late pregnancy, in the supine and right semiprone positions. In the supine position hypertensive pregnant women show significantly lower blood pressures in the leg than in the arm when compared with normotensive pregnant women and nonpregnant controls. Recordings made in the right semiprone position cannot be interpreted with confidence owing to probable positional variations of the limbs with respect to the horizontal plane through the heart. A theory is proposed relating aortic compression by the gravid uterus and subsequent utero‐placental ischaemia, with hypertensive proteinuria and pre‐eclamptic toxaemia.
CYANOTIC CONGENITAL HEART DISEASE AND PREGNANCY
Authors: Batson Gerald A. 
Published: August 2005

SummaryThe obstetric performance of 19 patients with fully documented cyanotic congenital heart disease was analyzed. There were 50 pregnancies in the decade 1962 to 1972 with no maternal death. The results support the views that pregnancy is not contra‐indicated, that therapeutic abortion is not indicated, and that the offspring of these mothers are below average birthweight
THE ORGANIZATION AND RESULTS OF A PREGNANCY TERMINATION SERVICE IN A NATIONAL HEALTH SERVICE HOSPITAL
Authors: Hull M. G. R. , Gordon Celia , Beard R. W. 
Published: August 2005

SummaryA pregnancy termination service has been set up for patients living in the catchment area of a National Health Service hospital, without expansion of staff or facilities except by one extra, lay counsellor. The use of beds has been minimized by employing outpatient techniques in the majority of suction abortions. The organization is described in detail and the role of the counsellors is stressed. In the first year of the service, 488 of 529 patients who attended the weekly clinics had their pregnancy terminated; 433 had a suction abortion, 75 per cent of which were done under local anaesthesia, the proportion increasing to 93 per cent with greater experience. The use of local anaesthesia for suction abortion, compared with general anaesthesia, was not associated with any increase in the incidence of incomplete evacuation of the uterus (5.9 per cent) or possible sepsis (5.1 per cent) amongst women followed up, but there was a much smaller operative blood loss up to 10 weeks' gestation. Intrauterine contraceptive devices (IUCD) were fitted at the end of 44 per cent of suction abortions and this procedure was not associated with any increased incidence of postoperative pain or sepsis. The results in patients whose pregnancy was terminated by other methods are also reported. Following abortion, 84 per cent of patients attended a special follow‐up and contraception clinic. Of all patients who underwent abortion, at least 82 per cent were using a reliable contraceptive method (oral, IUCD, or sterilization), and, in addition, a quarter of those not followed up had been fitted with an IUCD after suction abortion.
GLOMERULAR FILTRATION DURING AND AFTER PREGNANCY
Authors: Davison J. M. , Hytten F. E. 
Published: August 2005

SummaryGlomerular filtration rate was estimated by three methods in ten healthy women during pregnancy at 15 to 18 weeks, 25 to 28 weeks and 35 to 38 weeks; and again 8 to 12 weeks post‐partum.During infusion the glomerular filtration rate was found to be raised from a non‐pregnant level of about 110 ml. per minute to a plateau of about 170 ml. per minute throughout pregnancy, whether the clearance was of infused inulin or endogenous creatinine. A 24‐hour creatinine clearance, measured the day before the infusion, gave a systematically lower estimate; it rose from a non‐pregnant mean of about 100 ml. per minute to a plateau at about 150 ml. per minute, which fell in late pregnancy to about 130 ml. per minute.It is concluded that an estimate of glomerular filtration rate is only valid for the conditions under which it is measured, that infusion probably raises the rate; and that the fall in late pregnancy which has been generally regarded as an “artefact” of posture may nevertheless represent the real life situation.
AN ASSESSMENT OF THE ANALGESIC EFFECT IN LABOUR OF PETHIDINE AND 50 PER CENT NITROUS OXIDE IN OXYGEN (ENTONOX)
Authors: Holdcroft Anita , Morgan M. 
Published: August 2005

SummaryThe effectiveness in clinical practice of conventional analgesia, with pethidine and 50 per cent nitrous oxide in oxygen (Entonox) has been studied in 663 consecutive patients. More than 75 per cent of mothers stated that they had obtained little or no pain relief from pethidine in the manner in which it was administered. In comparison, nearly half the patients who received Entonox had satisfactory analgesia and the incidence of acceptable pain relief with both agents was unrelated to parity. The number of patients receiving satisfactory analgesia was disturbingly low.
THE PATTERN OF INCIDENT AGE DISTRIBUTION WITH CLINICAL STAGING FOR CANCER OF THE CERVIX IN ENGLAND AND WALES FROM 1945 to 1969
Authors: Mould R. F. 
Published: August 2005

SummaryThe incident age distribution for Stage I, Stage II and Stage III carcinoma of the cervix in 12 regions in England and Wales between 1945 and 1969 was studied. For the various geographical areas considered during the same five‐year period, the mean age points for a given stage of carcinoma of the cervix were usually tightly clustered. The highest mean ages for a given stage were usually found in the least industrialized areas and this was most noticeable for the period 1965 to 1969. The mean age for Stage I carcinoma of the cervix fell slightly between 1950 and 1969. No similar decrease occurred for Stages II and III.
URINARY OESTRIOL EXCRETION IN TWIN PREGNANCIES
Authors: Duff G. B. , Brown J. B. 
Published: August 2005

SummaryThe results of 201 24‐hour urinary oestriol estimations in 50 twin pregnancies are presented. The 10th, 50th and 90th centiles were approximately 1.7 times higher than those for singleton pregnancies, reflecting the combined weights of the two fetuses. In general, the oestriol values were not low before or after intrauterine death of one fetus or in pregnancies with intrauterine growth retardation. The trends in serial oestriol values were of more relevance in assessing fetal jeopardy than grading the values as normal or low.
A CLINICAL TRIAL OF THE VALUES OF SERUM HEAT STABLE ALKALINE PHOSPHATASE ESTIMATES IN PREDICTING THE OCCURRENCE OF PRE‐ECLAMPSIA
Authors: McCorry R. L. , Mollan R. A. B. , Neely M. R. 
Published: August 2005

SummaryIn a prospective study, the levels of heat stable alkaline phosphatase (HSAP) in the serum of a series of 396 patients were found to offer no guidance in the prediction of the occurrence and severity of pre‐eclamptic toxaemia.
17‐β‐OESTRADIOL AND THE FIBRINOLYTIC ACTIVITY OF VEIN WALLS
Authors: ÅStedt Birger , Jeppsson Sten 
Published: August 2005

SummaryCoagulation and fibrinolytic studies were performed on 16 postmenopausal women before and during treatment with 10 mg. of 17‐β‐oestradiol a day for 10 days. The fibrinolytic activity in the wall of a biopsy specimen of a superficial vein was determined histochemically and was unchanged. The concentration of antithrombin III decreased slightly from a mean of 105 per cent to 90 per cent.