bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide association studies for the number of piglets born alive and dead in Dongliao black pigs
Authors: Sun Hao , Cheng Yu , He Yu , Cheng Chao , Zhao Hongxia , Yang Sumei , Wei Meng , Yang Jingxiu , Liang Shuang , Bai Chunyan , Sun Boxing 
Published: December 2023

AbstractLitter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome‐wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous pig reproduction association studies. We suggest that rs81318434, located in the GLI3 gene, might be the promising candidate affecting litter size trait. Our findings may provide insights for uncovering the genetic mechanisms for the litter size of pigs.
Incidence of glaucoma filtration surgery from disease onset of open‐angle glaucoma
Authors: Virtanen Aapo , Haukka Jari , Loukovaara Sirpa , Harju Mika 
Published: December 2023

AbstractAimsTo investigate the rate and risk factors of undergoing glaucoma filtration surgery (GFS) in patients with newly diagnosed open‐angle glaucoma (OAG).MethodsThis is a population‐based historic cohort study, consisting of 9420 patients older than 45 years diagnosed with OAG during 1997–2010. Follow‐up spanned from 1997 to 2017. We obtained data for trabeculectomy (TRE), deep sclerectomy (DS), and glaucoma drainage implant (GDI) surgeries from national administrative healthcare registers by hospital billing data. We plotted the cumulative incidence of GFS and carried out a multivariate Poisson regression analysis adjusted for age, sex, hospital district, systemic comorbidities, and the number of IOP‐lowering drugs. We reported incidence rate ratios (IRR) with 95% confidence intervals (CI) for GFS after the onset of OAG.ResultsThe cumulative incidence of GFS at 5 years from OAG onset was 3.1% and at 10 years 5.4%. Age over 80 years at baseline was associated with lower GFS incidence (IRR 0.51, CI 0.31–0.84). The number of IOP‐lowering drugs in the first 2 years of treatment correlated with the risk of GFS increasing from (IRR 3.23, CI 2.32–4.50) for two drugs, (IRR 7.44, CI 5.28–10.47) for three and to (IRR 14.95, CI 10.38–21.52) for four drugs.ConclusionThis study characterized the treatment path of OAG from diagnosis to surgical intervention refining the role of GFS among glaucoma therapies.
Proactive vitality management, goal attainment, and psychological well‐being among college students: A weekly diary study
Authors: Ren Yue , Wang Huatian , Li Jingru 
Published: December 2023

AbstractStudent well‐being is under renewed scrutiny due to escalating academic stress and mental health concerns among young adults. However, in addition to the measures taken by lecturers, universities, and local governments (top‐down approaches), we still know little about how students themselves can take the proactive strategy to manage their well‐being (bottom‐up approaches). The current study addressed this gap by proposing and examining the beneficial role of proactive vitality management (PVM)—a proactive action aimed at managing physical and mental energy based on personal unique needs and conditions—on student psychological well‐being. We collected data from 97 college students (36% male, age mean = 21) over four consecutive weeks (308 data observations) and tested a multilevel moderated mediation model. Results showed that weekly PVM was positively related to student weekly goal attainment, which, in turn, enhanced the current week's well‐being and the next week's well‐being as well. Further, this positive indirect (carryover) effect of PVM through goal attainment on well‐being was stronger for those who had a high learning orientation. Our results indicated that PVM can be an effective self‐customized strategy to manage college students' weekly well‐being. Theoretical and practical implications were discussed.
Can low‐dose intravenous bevacizumab be as effective as high‐dose bevacizumab for cerebral radiation necrosis?
Authors: Gao Miaomiao , Wang Xin , Wang Xiaofeng , Niu Gengmin , Liu Xiaoye , Zhao Shuzhou , Wang Yue , Yu Huiwen , Huo Siyuan , Su Hui , Song Yongchun , Wang Xiaoguang , Zhuang Hong‐Qing , Yuan Zhi‐Yong 
Published: December 2023

AbstractAlthough intravenous bevacizumab (IVBEV) is the most promising treatment for cerebral radiation necrosis (CRN), there is no conclusion on the optimal dosage. Our retrospective study aimed to compare the efficacy and safety of high‐dose with low‐dose IVBEV in treating CRN associated with radiotherapy for brain metastases (BMs). This paper describes 75 patients who were diagnosed with CRN secondary to radiotherapy for BMs, treated with low‐dose or high‐dose IVBEV and followed up for a minimum of 6 months. The clinical data collected for this study include changes in brain MRI, clinical symptoms, and corticosteroid usage before, during, and after IVBEV treatment. At the 3‐month mark following administration of IVBEV, a comparison of two groups revealed that the median percentage decreases in CRN volume on T2‐weighted fluid‐attenuated inversion recovery and T1‐weighted gadolinium contrast‐enhanced image (T1CE), as well as the signal ratio reduction on T1CE, were 65.8% versus 64.8% (p = 0.860), 41.2% versus 51.9% (p = 0.396), and 37.4% versus 35.1% (p = 0.271), respectively. Similarly, at 6 months post‐IVBEV, the median percentage reductions of the aforementioned parameters were 59.5% versus 62.0% (p = 0.757), 39.1% versus 31.3% (p = 0.851), and 35.4% versus 28.2% (p = 0.083), respectively. Notably, the incidence of grade ≥3 adverse events was higher in the high‐dose group (n = 4, 9.8%) than in the low‐dose group (n = 0). Among patients with CRN secondary to radiotherapy for BMs, the administration of high‐dose IVBEV did not demonstrate superiority over low‐dose IVBEV. Moreover, the use of high‐dose IVBEV was associated with a higher incidence of grade ≥3 adverse events compared with low‐dose IVBEV.
Results of patch testing 2‐hydroxyethyl methacrylate (HEMA) in the European baseline series: A 4‐year retrospective study
Authors: Kocabas Gizem , Steunebrink Iemke M. , de Groot Anton , Rustemeyer Thomas 
Published: December 2023

AbstractBackground2‐Hydroxyethyl methacrylate (HEMA) was added to the European baseline series (EBS) in 2019. Few recent data are available on the frequency and relevance of positive reactions to this hapten.ObjectivesTo investigate the frequency and relevance of positive patch tests to HEMA in the EBS in a university hospital in Amsterdam, The Netherlands.Patients and MethodsRetrospective study in patients with positive patch tests to HEMA investigated between June 2019 and August 2023.ResultsOf 2927 consecutive patients, 88 (79 women and 9 men; 3.0%) had a positive reaction to HEMA. The prevalence in women was 3.9%, in men 1.0%. Forty‐three (49%) reactions were judged to be of current clinical relevance and 21 (24%) of past relevance. In this group of 64 patients with relevant reactions, 18 (28%) had occupational contact with (meth)acrylate‐containing products, of who 11 (61%) were nail stylists. In 46 patients with non‐occupational allergic contact dermatitis, 31 (67%) had allergic reactions to nail cosmetics. Glues and glue‐containing products accounted for 22% of the materials causing allergic contact dermatitis and dental products for 8%.ConclusionsAllergic reactions to HEMA are very frequent in women investigated in Amsterdam. Nearly two thirds of cases were caused by nail cosmetics.
Whole‐body MRI with diffusion‐weighted imaging as an adjunct to18F‐fluorodeoxyglucose positron emission tomography and CT in patients with suspected recurrent colorectal cancer
Authors: Willemse Jeroen R. J. , Lahaye Max J. , Kok Niels F. M. , Grotenhuis Brechtje A. , Aalbers Arend G. J. , Beets Geerard L. , Rijsemus Charlotte , Maas Monique , van Golen Larissa W. , Beets‐Tan Regina G. H. , Lambregts Doenja M. J. 
Published: December 2023

AbstractAimThe aim was to explore how findings of whole‐body MRI including diffusion‐weighted imaging (DW‐MRI) compared to the routine diagnostic workup with CT and/or 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT in patients with suspected recurrent colorectal cancer (CRC).MethodThis was an exploratory retrospective analysis of 55 patients with a clinical suspicion of recurrent CRC who underwent DW‐MRI following CT and/or FDG‐PET/CT. Two readers in consensus interpreted all clinical imaging reports and converted each described lesion into a confidence score (1 = definitely benign to 5 = definitely malignant). DW‐MRI findings were compared to the most recent previous CT or PET/CT. Any discrepant or additional DW‐MRI findings were documented and compared with histology and/or clinical follow‐up (if available).ResultsWhole‐body MRI including diffusion‐weighted imaging (DW‐MRI) resulted in discrepant/additional findings in 26/55 (47%) cases; 23/37 (62%) compared to previous CT and 3/18 (17%) compared to previous PET/CT. These included 10 cases where DW‐MRI converted previously inconclusive CT (n = 8) or PET/CT (n = 2) findings into a conclusive diagnosis, one where it contradicted a previous CT diagnosis of recurrence, five where DW‐MRI diagnosed recurrent disease not previously reported on CT and 10 cases where DW‐MRI detected additional lesions compared to CT (n = 9) or PET/CT (n = 1). Eighty‐eight per cent of cases with discrepant/additional findings concerned patients with recurrent/metachronous peritoneal metastases. In total, DW‐MRI resulted in 42 discrepant/additional lesions; the DW‐MRI diagnosis was correct in 76% of these lesions and incorrect (false positive) in 7%. In the remaining 17%, no standard of reference was available.ConclusionsThis explorative study suggests that DW‐MRI may be of added value to patients with a clinical suspicion for recurrent CRC, in particular to identify patients with peritoneal metastases. DW‐MRI mainly has potential as a ‘problem‐solver’ in patients with inconclusive or negative findings on previous imaging (in particular CT) and to detect additional disease sites in patients already diagnosed with recurrent disease.
The effect of observing multiple private information outcomes on the inclination to cheat
Authors: Casal Sandro , Filippin Antonio 
Published: December 2023

AbstractWe investigate how the inclination to cheat changes when agents report the result of multiple realizations of a (private information) stochastic event rather than a single outcome. Multiple realizations render extreme outcomes unlikely, facilitating the identification of opportunistic behaviors and exposing to reputation concerns the individuals who report them. Consequently, multiple realizations lead to a significant reduction of cheating by large amounts. Simultaneously multiple realizations also diminish the intrinsic cost of lying, thereby inducing a widespread inclination to adjust upward the observed outcome in a plausible manner. The overall effect is only a marginal decrease in the degree of cheating.
Addressing power in couples therapy: Integrating socio‐emotional relationship therapy and emotionally focused therapy
Authors: Jenks Amanda , Adams Gwen , Young Bonnie , Seedall Ryan 
Published: December 2023

AbstractRomantic relationships are more satisfying and fulfilling when power is balanced relatively equally between partners (Leonhardt et al., Journal of Family Psychology, 34, 2020, and 1). Yet, few couples therapy models explicitly outline how to confront relational power issues (Knudson‐Martin & Huenergardt, 2015, Socio‐emotional relationship therapy: Bridging emotion, societal context, and couple interaction, Springer). Emotionally Focused Therapy (EFT; Johnson, 2020, The practice of emotionally focused couple therapy, Routledge) is a well‐established, evidence‐based therapy modality that many therapists use with couple clients, yet despite its effectiveness, it does not provide direction for explicitly addressing and treating power differentials in couple relationships. In this paper, we explore the integration of EFT with Socio‐emotional Relationship Therapy (SERT), a model overlay that acknowledges the impact of social discourse on enactments of power in intimate couple relationships. We first address the importance of understanding power in couple relationships, addressing power in couples therapy, and provide a brief overview of SERT and EFT. We then introduce an integration of the models intended to help therapists balance power, increase connection, and secure attachment bonds between romantic partners.
The equity of carbon emissions in international trade from the perspective of value added
Authors: Kou Jingwen , Ma Weijing , Li Chengyi , Yang Haijiang , Xue Bing , Gou Xiaohua 
Published: December 2023

AbstractInternational trade drives the transboundary transfer of carbon emissions. However, due to the differences in the economic development level and industrial structure of countries, the whole understanding of the inequality exchange between carbon emissions and the value added remains to be illuminated. Here, to uncover the global pattern of this inequality exchange, we construct a multi‐regional input–output model (MRIO) and inequality exchange index (IEI) from 1991 to 2016, to carry out macro path research with the goal of achieving global carbon neutrality. The results show that: (1) The carbon emissions per unit of value added through trade have declined in most countries, and the decline rate of developing countries was faster than that of developed ones. (2) In general, the developed countries were in an advantageous position in the value added and carbon emission exchange, while the developing countries were in a disadvantageous position. (3) Six sectors – agriculture, forestry, and animal husbandry; electrical and machinery; electricity, gas, and water; petroleum, chemical, and N‐metallic mineral products; transport; and financial intermediation and business activities – accounted for more than half of the carbon emissions of global trade, but with the advancement of energy conservation and emission‐reduction measures, carbon emissions have decreased to varying degrees. (4) From a global perspective, promoting cooperation on carbon reduction technologies from developed countries to developing ones might be a key and effective way to achieve global carbon reduction. The study aims to provide new insights into the formulation of global carbon neutrality and carbon emission responsibility‐sharing policies.
Classic Scottish sandstone concretions formed from hot water
Authors: Hudson John D. , Paxton Richmal B. , Andrews Julian E. , Dennis Paul F. , Marca Alina D. 
Published: December 2023

Large calcite‐cemented sandstone concretions found in Middle Jurassic sandstones from the isles of Eigg and Skye are a striking feature of the Jurassic geology of the Inner Hebrides. Recent clumped isotope data unequivocally give concretionary calcite cementation temperatures above 50°C and up to 98°C. The high temperatures contrast with the mild thermal history of the enclosing less permeable Jurassic mudrocks. The clumped isotope data also enable calculation of the oxygen isotopic composition of the precipitating fluids: these included percolating rainwater that had interacted with Paleocene volcanics; then, later hot fluids of deeper, basinal origin, squeezed out of compacting mudrocks at depth as the Paleocene lava pile loaded the crust. There is thus direct connection between ‘Jurassic’ sedimentary features and the complex Paleocene volcanic history of the region.
The workplace as a site of abortion surveillance
Authors: Bloomer Fiona , Mackle Danielle , MacNamara Nóirín , Pierson Claire , Bloomer Stephen 
Published: December 2023

AbstractAnalysis of the experiences and resulting inequalities in reproductive health in the workplace has generated studies of pregnancy, miscarriage, menstruation, fertility and menopause. One issue that has remained outside of this literature is abortion. How abortion is talked about (or not talked about), experienced and perceived as a workplace issue were the central questions in our research undertaken in the Republic of Ireland and Northern Ireland in 2017. Our study comprised a survey (3180 respondents) followed by a series of online focus groups (61 participants) with trade union members from a broad range of workplaces, with the aim of investigating how abortion was positioned in workplaces within legally restrictive regimes. We conceptualize how self‐disciplining, silence and abortion stigma are reproduced in workplaces, drawing on a feminist Foucauldian framework to examine disciplinary power. We examine evidence of how, in conservative societies, abortion talk is suppressed, and we generate new theoretical knowledge on how disciplinary power undermines resistance to anti‐abortion norms and demonstrate the function of the normalizing gaze in the workplace. We conclude by offering avenues for future research on abortion stigma and disciplinary power, to extend further knowledge and conceptual framing of abortion as a workplace issue.
Cost‐effectiveness analysis of emicizumab prophylaxis in patients with haemophilia A in India
Authors: Seth Tulika , John M. Joseph , Chakrabarti Prantar , Shanmukhaiah Chandrakala , Verma Shailendra Prasad , Radhakrishnan Nita , Dolai Tuphan Kanti 
Published: December 2023

AbstractIntroductionEmicizumab is the initial subcutaneously administered bispecific antibody approved as a prophylactic treatment for patients with haemophilia A (PwHA).AimThis study assessed the economic evaluation of emicizumab treatment for non‐inhibitor severe haemophilia A (HA) patients in India.MethodsA Markov model evaluated the cost‐effectiveness of emicizumab prophylaxis compared to on‐demand therapy (ODT), low‐dose prophylaxis (LDP; 1565 IU/kg/year), intermediate‐dose prophylaxis (IDP; 3915 IU/kg/year) and high‐dose prophylaxis (HDP; 7125 IU/kg/year) for HA patients without factor VIII inhibitors. Inputs from HAVEN‐1 and HAVEN‐3 trials included transition probabilities of different bleeding types. Costs and benefits were discounted at a 3.5% annual rate.ResultsIn the base‐case analysis, emicizumab was cost‐effective compared to HDP, with an incremental cost‐effectiveness ratio (ICER) per quality‐adjusted life‐years (QALY) of Indian rupees (INR) 27,869. Compared to IDP, ODT and LDP, emicizumab prophylaxis could be considered a cost‐effective option if the paying threshold is >1 per capita gross domestic product (GDP) with ICER/QALY values of INR 264,592, INR 255,876 and INR 305,398, respectively. One‐way sensitivity analysis (OWSA) highlighted emicizumab cost as the parameter with the greatest impact on ICERs. Probabilistic sensitivity analysis (PSA) indicated that emicizumab had a 94.7% and 49.4% probability of being cost‐effective at willingness‐to‐pay (WTP) thresholds of three and two‐times per capita GDP.ConclusionEmicizumab prophylaxis is cost‐effective compared to HDP and provides value for money compared to ODT, IDP, and LDP for severe non‐inhibitor PwHA in India. Its long‐term humanistic, clinical and economic benefits outweigh alternative options, making it a valuable choice in resource‐constrained settings.
RETRACTED: Effects of clinical nursing pathway on surgical site wound infection in patients undergoing acute appendicitis surgery: A meta‐analysis
Authors: Zhang Qin , Zhang Li‐Hua , Wu Jian‐Li , Yang Feng‐Yong 
Published: December 2023

AbstractThis study aimed to explore the impact of clinical nursing pathway applied to acute appendicitis surgery on patients' postoperative wound infections and complications. A computerised search of PubMed, Cochrane Library, Web of Science, EMBASE, Wanfang, Chinese Biomedical Literature Database and China National Knowledge Infrastructure was conducted and supplemented by a manual search, from database inception to October 2023, to collect randomised controlled trials (RCTs) on the application of clinical nursing pathways to acute appendicitis surgery. Literature screening, data extraction and quality assessment of the included literature were carried out independently by two researchers. RevMan 5.4 software was applied for data analysis. Twenty‐one RCTs with a total of 2408 patients were finally included. The analysis revealed the implementation of clinical nursing pathway could effectively reduce the incidence of wound infection (OR = 0.26, 95% CI: 0.15–0.46, p < 0.001) and postoperative complications (OR = 0.20, 95% CI: 0.15–0.27, p < 0.001), as well as shorten the hospital length of stay (MD = −3.26, 95% CI: −3.74 to −2.79, p < 0.001) and accelerated the time to first ventilations (MD = −14.85, 95% CI: −21.56 to −8.13, p < 0.001), as well as significantly improved patient satisfaction (OR = 5.52, 95% CI: 3.52–8.65, p < 0.001) in patients undergoing surgery for acute appendicitis. The application of clinical nursing pathway in acute appendicitis surgery can significantly reduce postoperative wound infection and complications, and at the same time can shorten the hospital length of stay as well as improve the satisfaction of patients.
Psoriasis and gut microbiota: A Mendelian randomization study
Authors: Wu Ruonan , Zhao Li , Wu Zewen , Liu Xinling , Li Jingxuan , Wang Tong , Zhang Liyun 
Published: December 2023

AbstractIn recent years, an increasing number of observational studies have revealed an association between gut microbiota composition and psoriasis patients. However, whether this association reflects a causal relationship remains unclear. This study aimed to identify the causal relationship between gut microbiota and psoriasis through relevant research. In order to determine whether gut microbiota and psoriasis are causally related, we conducted a Mendelian randomization analysis using summary statistics from genome‐wide association studies (GWAS). As the exposure factor, we used summary statistics data from a GWAS study conducted by the MiBioGen Consortium, including 18,340 individuals with whole‐genome gut microbiota composition, and data from the FinnGen GWAS study on psoriasis, including 9267 patients and 364,071 controls as the disease outcome. Two‐sample Mendelian randomization analysis was subsequently performed with inverse variance weighted, MR‐Egger and weighted median, while sensitivity analyses were conducted to address heterogeneity and horizontal pleiotropy. The IVW results confirmed the causal relationship between certain gut microbiota groups and psoriasis. Specifically, family Veillonellaceae (OR = 1.162, 95% CI: 1.038–1.301, p = 0.009), genus Candidatus Soleaferrea (OR = 1.123, 95% CI: 1.011–1.247, p = 0.030) and genus Eubacterium fissicatena group (OR = 0.831, 95% CI: 0.755–0.915, p = 0.00016) showed significant associations. Sensitivity analysis did not reveal any abnormalities in SNPs. Currently, we have found some causal relationship between the gut microbiota and psoriasis. However, the study needs further RCTs for further validation.