bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal ion (Mn+)‐condensed DNA nanoparticles: Synthesis, properties, and applications
Authors: Moon Jeesu , Kim Sang‐Won , Lee Jae‐Seung 
Published: January 2025

AbstractMetal ion (Mn+)‐induced DNA condensation is a critical process observed in both natural and synthetic contexts, playing a central role in the formation of nanoscale DNA‐based materials. This phenomenon leverages the ability of multivalent Mn+s to neutralize the negatively charged DNA phosphate backbone, promote electrostatic cross‐linking, and enable coordination bonding, leading to compact and organized DNA nanostructures. Recent advancements have focused on synthesizing Mn+‐condensed DNA nanoparticles (Mn+‐CDNPs) through controlled molecular assembly, utilizing the interplay of DNA sequence specificity, Mn+ type, and environmental conditions. The choice of Mn+ significantly influences the properties of Mn+‐CDNPs, imparting functionalities including fluorescence, magnetism, and catalytic activity, which are tailored for applications in biosensing, diagnostics, and therapeutic delivery. However, several challenges remain in fully realizing the potential of Mn+‐CDNPs. These include scalability issues, morphological control beyond isotropic spherical nanoparticles, and ensuring biocompatibility, particularly when using heavy Mn+s. Innovations in synthesis strategies, such as optimizing phase transitions during condensation and incorporating programmable DNA sequences, have enabled enhanced structural precision and functionality. Surface modification techniques, such as coating with metal–organic frameworks (MOFs) or silica shells, have further expanded the stability and applicability of Mn+‐CDNPs. Additionally, the inclusion of functional additives, such as drugs and proteins, has broadened their use in targeted therapy and controlled release systems. This review highlights the advances in the synthesis, properties, and applications of Mn+‐CDNPs, emphasizing their potential as multifunctional platforms for biomedical and nanotechnological innovations. Future efforts must address challenges in reproducibility, toxicity, and structural diversity through interdisciplinary approaches combining experimental, computational, and engineering strategies. By overcoming these barriers, Mn+‐CDNPs hold promise for transformative advancements in nanomedicine, chemical sensing, and programmable material design.
Platform Selection for Patients Undergoing Transcatheter Aortic Valve Replacement: A Practical Approach
Authors: Valvo Roberto , Popolo Rubbio Antonio , Sisinni Antonio , Squillace Mattia , Bedogni Francesco , Testa Luca 
Published: January 2025

ABSTRACTTransfemoral transcatheter aortic valve Replacement (TAVR) has become the standard therapy for patients with severe aortic stenosis in patients over 75 years old in Europe or 65 years old in the United States, regardless of the surgical risk. Furthermore, iterations of existing transcatheter aortic valves (TAVs), as well as devices with novel concepts, have provided substantial improvements with respect to the limitations of previous‐generation devices. Hence, treatment of a broader spectrum of patients has become feasible, and a sophisticated selection of the appropriate TAV tailored to patients' anatomy and comorbidities is now possible. Anatomy, patient characteristics, and operator experience must all inform proper device selection. This review describes the features and performance of the current generation of TAVs with the aim of providing a practical approach for clinicians when selecting the appropriate TAV for a specific patient.
Deciphering Barriers and Strategies in Environmental Management Accounting (EMA) Adoption: A Comprehensive Two‐Decade Analysis
Authors: Zatini Giacomo , Della Porta Armando , Za Stefano 
Published: January 2025

ABSTRACTThis study presents a comprehensive analysis of the evolution and challenges of Environmental Management Accounting (EMA) adoption across diverse industries and regions over the past two decades. Through a bibliometric analysis, this study categorizes the literature into three distinct periods, each elucidating crucial developments in EMA practices from initial theoretical formulations to their strategic integration with corporate sustainability and circular economy frameworks. The recent period particularly focuses on identifying the multifaceted challenges in EMA adoption, encapsulated in the newly developed “EMA adoption and application issue framework.” This framework not only categorizes but also visually represents systemic barriers such as regulatory constraints, organizational and cultural resistance, economic and technical obstacles, and the influence of external market forces. The analysis reveals significant regional disparities in EMA research, with a notable lack of contribution from European Union countries compared to active regions such as Australia, South Africa, and Southeast Asia, suggesting a critical need for strategic interventions to enhance EMA research and practical implementation in the EU. These findings advocate for more robust regulations, enhanced managerial commitment, and international collaboration to improve EMA adoption rates. This study aims to advance the understanding of EMA's implementation challenges and foster dialog among academics, policymakers, and practitioners to overcome these barriers and enhance the integration of EMA into sustainability strategies globally.
Improved Efficiency of Weakly Coupled Wireless High‐Power Transfer Systems by Loss‐Separation Strategy
Authors: The Nguyen Hoach , Al‐Sumaiti Ameena Saad , Alhassan Ahmad Bala , Do Ton Duc 
Published: January 2025

ABSTRACTIn the equivalent T‐model of the loosely coupled transformers, the small mutual inductance can lead to higher conducting currents, which cause high losses in the primary circuit and significantly reduce the overall transfer efficiency under weak‐coupling states. To overcome this challenge, this paper proposes a strategy to separate the primary loss components from the weak‐coupling stage. In the proposed strategy, a gyrator in the form of a double‐resonance T‐block is added just before the weak‐coupling stage to improve the overall efficiency. Then, the strategy is realized by various topologies such as compensating circuits, added coils, isolated transformers, and integrated‐/split‐ inductors/coils. Also, the optimized designs and component selection for resonance and the mathematical derivation for optimal load resistances were investigated. ANSYS comparative analyses of the topologies are presented by considering practical aspects, including component designs, power flows, transfer efficiency, resonance frequency shifting, and optimal loads. Finally, the analyses were validated using the fabricated experimental setups and demonstrated an efficiency improvement of about 5% for a case with a coupling factor of 0.1. The proposed strategy offers suggestions for industrial designs of high‐power wireless battery charging systems using resonant inductive coils.
Nectar‐Feeding Behavior in the Mallee Ringneck, Barnardius zonarius barnardi
Authors: Hewes Amanda E. , Rico‐Guevara Alejandro , McWhorter Todd J. 
Published: January 2025

ABSTRACTOpportunistic nectarivory occurs in many avian lineages around the world. In order to understand the implications of this behavior to plant reproduction via pollination and to other nectarivores via competition, more thorough descriptions of opportunistic nectar‐feeding behavior are necessary. We observed nectar feeding of the mallee ringneck, Barnardius zonarius barnardi, on flowers of the spotted emu bush, Eremophila maculata, in the temperate mallee of South Australia. Here, we describe the nectar‐feeding behavior of B. zonarius barnardi and discuss the implications for competition with honeyeaters and the reproduction of E. maculata. We also compare the morphology of the feeding apparatus of B. zonarius barnardi with that of nectarivorous parrots, lorikeets and lories, to determine whether they share convergent morphological features to facilitate the consumption of nectar. Finally, we suggest avenues for future natural history work to better document opportunistic avian nectarivory in Australian ecosystems.
Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction
Authors: Wleklik Marta , Lee Christopher S. , Lewandowski Łukasz , Czapla Michał , Jędrzejczyk Maria , Aldossary Heba , Uchmanowicz Izabella 
Published: January 2025

AbstractAimsThis study aimed to identify factors associated with frailty in heart failure (HF) patients, focusing on demographic, biochemical and health‐related variables. It also explored the correlation between frailty and comorbidities such as malnutrition, cognitive impairment and depression, assessing how these factors interact to influence frailty risk.MethodsA total of 250 HF patients (mean age 73.5 ± 7.2 years; 45.6% female) hospitalized for acute decompensated HF were included. Frailty was assessed using Fried phenotype criteria. Cognitive function, depression and nutritional status were evaluated using validated instruments [Mini‐Mental State Examination (MMSE), Patient Health Questionnaire‐9 (PHQ‐9) and Mini Nutritional Assessment (MNA)]. Biochemical markers included C‐reactive protein (CRP), N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP), haemoglobin, estimated glomerular filtration rate (eGFR) and systolic blood pressure (SBP). Statistical analyses, including logistic regression, were performed to assess associations and odds ratios (ORs) for frailty, adjusted for inflammation and HF type.ResultsFrailty was present in 60.4% of patients. Frail individuals exhibited significantly higher CRP (median 4.60 vs. 2.54 mg/L, P < 0.001) and NT‐proBNP (median 2558.8 vs. 1102.6 pg/mL, P = 0.001) and lower haemoglobin (13.7 vs. 14.3 g/dL, P = 0.012), eGFR (62 vs. 71 mL/min/1.73 m2, P = 0.025) and SBP (130 vs. 134 mmHg, P = 0.026). Each 10% increase in CRP was associated with a 5.5% increase in frailty odds (P < 0.001). Frailty was linked to cognitive impairment (OR 2.1, P = 0.018), malnutrition (OR 3.0, P < 0.001) and depression (OR 3.1, P < 0.001), while high adherence to treatment reduced frailty risk by 78.9% (P = 0.027). Interactions were observed between cognitive impairment and body mass index (BMI) (P = 0.020), where higher BMI mitigated the frailty odds difference between cognitively impaired and unimpaired patients. Depression's association with frailty odds varied by adherence levels (P = 0.034) and central obesity (P = 0.047), with the absence of depression offering protection against frailty in patients with central obesity. These interactions remained significant after adjustment for HF type and left ventricular ejection fraction (LVEF) and were consistent across stratifications by these factors.ConclusionsFrailty in HF is influenced by inflammatory markers, cognitive impairment and psychosocial factors. Elevated CRP and NT‐proBNP were strong predictors of frailty. Cognitive impairment and depression were key modifiable factors, interacting with BMI, adherence and obesity. Targeting these factors with early interventions could mitigate frailty risk, improving outcomes and quality of life in HF patients.
Complexes of d‐ and f‐metal Ions with Redox‐Active and Highly Symmetric Truxenone Ligand: Effect of Cations and Coordination on Distortions of Radical Anions and Singlet–Triplet Transition in Dianions
Authors: Krivenko Kira D. , Shestakov Alexander F. , Faraonov Maxim A. , Kuzmin Alexey V. , Khasanov Salavat S. , Otsuka Akihiro , Yamochi Hideki , Kitagawa Hiroshi , Konarev Dmitri 
Published: January 2025

Truxenone (Tr) with high C3h symmetry forms crystalline radical anion and dianion salts. The {Bu3MeP+}(Tr·−)(1) and {Cp*2Co+)}(Tr·‐).2C6H4Cl2(2) show intense low‐energy absorption up to 2000nm. Calculations predict Jahn–Teller distortions for Tr·‐, which are enhanced by the asymmetric approach of cations to Tr·‐, leading to C=O bond length alternation and EPR signal asymmetry in 2. Two cesium ions form short contacts of 3.07–3.35Å with oxygen atoms of Tr2‐ in {Cryptand[2.2.2](Cs+)}2(Tr2‐)(3), linking the dianions into a 1D polymer. Calculations suggest a triplet state for the dianions, but the unsymmetric approach of Cs+ to the oxygen atoms of Tr2‐ stabilizes the singlet ground state. The triplet state is populated above 100K. An estimated singlet–triplet energy gap is 344±7K. Radical anions of Tr·‐ coordinate with one d‐ or f‐metal, forming {Cp*2Co+}{TbIII(TMHD)3×Tr}‐.1.5C7H8(4) and {Cp*2Co+}{MnII(acac)2×Tr}‐.2.4C6H4Cl2(5). Strong antiferromagnetic TbIII–Tr·‐ coupling (J =−7.6cm−1) aligns spins of TbIII and Tr·‐ antiparallel in 4. The χMT value of 3.32 emu×K/mol at 300K for 5 with high‐spin MnII is lower‐than‐expected. That indicates a spin state of S=2 owing to the antiparallel alignment of MnII and Tr·‐ spins. Strong MnII–Tr·‐ coupling arising from the spin density localization on the oxygen coordinated to MnII. Complexes with metals demonstrate low‐energy absorption with maxima at 1504–1740nm.
Glacier area variation in Uttarakhand Himalaya: Investigating trends and influencing factors
Authors: Shrivas Iti , Guha Supratim , Tiwari Reet Kamal , Prajapati Mohit , Taral Ashutosh Laxman 
Published: January 2025

AbstractUnderstanding the intricate interplay between topography and glacier changes is vital for predicting future water resources and addressing the impacts of climate change. This study examines changes in glacier area in the Uttarakhand Himalayan region, where the River Ganga originates, between 2000 and 2023 using high‐resolution satellite imagery. A manual digitization process was employed to delineate the glacier boundaries of 116 glaciers for the years 2000 and 2023. Multivariate regression analysis was then conducted to identify and quantify the controlling topographical and morphological parameters. The analysis revealed significant reductions in total glacier area, decreasing from 979.05 ± 46.89 km2 in 2000 to 957.60 ± 13.67 km2 in 2023, with an overall deglaciation rate of 0.095% per year, highlighting variability in glacier responses. This variability is driven by a complex interplay of mainly slope, shape index, glacier elevation and surface ice velocity. Among these factors, the shape index emerged as the most influential. Glaciers with a higher shape index (more elongated) were found to be more stable than those with a lower shape index (more circular). A 10% difference in shape index results in a glacier with a higher shape index losing 0.112% per year less area compared to a glacier with a lower shape index. The second controlling parameter is glacier slope; glaciers with a 10% steeper slope lost 0.11% per year less area compared to those with a gentler slope. The other two parameters showed some minor impact on glacier area variation in the sample glaciers but not across the entire Uttarakhand region.
Survival, Tumor Control, and Safety Outcomes of Proton Therapy in Sinonasal Cancer Population: A Systematic Review and Meta‐Analysis
Authors: Vasudevan Srivatsa Surya , Candelo Estephania , Sharifi Alireza , Ma Daniel J. , Patel Samir H. , Routman David M. , Holtzman Adam L. , Mohammadi Homan , Donaldson Angela M. 
Published: January 2025

ABSTRACTBackgroundIn sinonasal cancer (SNC), treatment with proton therapy (PT) provides excellent local control, especially after gross total resection. Because of the heterogeneity and rarity of this disease site, a comprehensive assessment of toxicity, survival, and control rates is lacking. Our primary objective was to assess the toxicity outcomes of PT in SNC patients, with a secondary aim of assessing survival and tumor control after PT.MethodsPubMed, Embase, EBSCO, Scopus, Science Direct, Web of Science, Ovid, Proquest, and Cochrane Library were searched from inception to August 2024 reporting PT acute and late toxicity, survival, and tumor control outcomes in SNC patients. A random‐effect meta‐analysis was used to assess the pooled safety, survival, and tumor control outcomes. The primary analysis was to report acute and late toxicity. The secondary aims included overall survival (OS), disease‐free survival (DFS), local control (LC), regional control (RC), and distant metastasis control (DMC) rate.ResultsFourteen studies were included for qualitative analysis. We pooled data from 756 patients who received PT for SNC. Among acute toxicity (AT), there was a 31.9% occurrence rate of grade ≥ 3 events, whereas within late toxicity (LT), grade ≥ 3 events occurred at a rate of 35.3%. Most LT (62.1%) were classified as grade 2, with the most frequent being ocular (24.8%) or neurological (18.4%) toxicities. The most common grade ≥ 3 toxicities were mucositis (15.3%) in AT and ocular toxicity (9.6%) in LT. The pooled 5‐year OS, DFS, LC, RC, and DMC were 36.8%, 34.2%, 35.6%, 28.6%, and 54.3%, respectively.ConclusionOur analysis demonstrates that PT‐treated SNC patients experience acceptable rates of acute and LT consistent with other published outcomes with highly conformal radiation techniques. PT demonstrates favorable OS and DFS. Further prospective and comparative effectiveness research is needed to better quantify the magnitude of the benefit of PT or other forms of radiation modalities.
Brain Morphometry of Toddlers With Language Delay: An Exploratory Study
Authors: Filippi Courtney A. , Smith Elizabeth , Redcay Elizabeth , Hazlett Heather , Thompson Lauren , Manwaring Stacy S. , D'Souza Precilla , Thurm Audrey 
Published: January 2025

ABSTRACTWhile studies have documented neural correlates of language delay in toddlers with developmental conditions, those at genetic risk for language delay, and those born premature, no studies have examined neural correlates in toddlers exhibiting early language delay without known aetiology. This study examines brain morphometry in toddlers with and without early language delay. To do so, we collected magnetic resonance imaging (MRI) on toddlers with language delay (LD; n = 7, Mage = 19.67 months, 3 female, 2 Hispanic and 4 non‐caucasian) and a typically developing (TD; n = 17, Mage = 22.73 months, 8 female, 2 Hispanic and 3 non‐caucasian) comparison group. Exploratory analyses examined group differences in total brain volume, cortical thickness and cortical surface area using both a whole‐brain and region of interest (Broca's and Wernicke's areas) approach. Results showed no gross brain anatomical differences between groups. However, there were group differences in cortical surface area in the temporal cortex (including Wernicke's area and left middle temporal gyrus, hedges' g = − 0.35) and Broca's area thickness. Results are reported using multiple analytic methods, age matching and exclusion of children later diagnosed with autism. While this exploratory study has a limited sample size, it provides novel findings that can be utilised to guide hypothesis‐driven imaging studies on toddler language delay.
Hybrid remote and in‐clinic maternal‐fetal surveillance for women with gestational diabetes: A prospective pilot study
Authors: Axelrod Michal , Lahav Ezra Hila , Galler Esther , Nir Omer , Ofir Keren , Barkai Galia , Sivan Eyal , Mazaki‐Tovi Shali , Tsur Abraham 
Published: January 2025

AbstractObjectiveThis study explores a hybrid approach to maternal‐fetal care for gestational diabetes (GD), integrating virtual visits seamlessly with in‐clinic assessments. We assessed the feasibility, time efficiency, patient satisfaction, and clinical outcomes to facilitate wider adoption of maternal‐fetal telemedicine.MethodsWe conducted a 4‐week prospective study involving 20 women with GD at ≥32 weeks of pregnancy, alternating between remote and in‐clinic weekly visits. Remote assessments began with women self‐measuring vital signs and using a digital urine dipstick. The remote encounter started with a midwife performing anamnesis and remotely connecting women to the fetal nonstress test. A physician concluded the meeting with remote sonographic assessment of amniotic fluid maximal vertical pocket that together with the nonstress test provided the modified biophysical assessment as well as a video encounter and ongoing glycemic control assessment. We assessed the feasibility of remote visits, compared visit durations, evaluated women's satisfaction using the Telehealth Usability Questionnaire, examined glucose documentation adherence during hybrid care compared with the following period until birth, and assessed GD‐related clinical outcomes.ResultsRemote visits had a success rate of 97.4% (38 of 39), with significantly shorter durations compared with in‐clinic visits (median 59.0 min vs. 159.0 min, P < 0.001). Women expressed high satisfaction (6.6 of 7), and adherence with recording fasting glucose values during the study period was significantly higher than the following period until birth (92.2% vs. 61.8%, P = 0.001). Notably, none required induction of labor for glycemic control imbalance, and there were no cases of macrosomia, shoulder dystocia, or neonatal hypoglycemia.ConclusionThe hybrid approach to maternal‐fetal care for GD demonstrated feasibility, safety, time efficiency, improved patient satisfaction, and enhanced glycemic control adherence.
Suction tube uterine tamponade versus uterine balloon tamponade for treatment of refractory postpartum hemorrhage: A randomized clinical feasibility trial
Authors: Singata‐Madliki Mandisa , Nieto‐Calvache Albaro J. , Rivera Torres Luisa F. , Abdul Hazmath , Batting Joanne , Cebekhulu Sylvia N. , Chauke Lawrence , Soma‐Pillay Priya , Fawcus Susan , Govender Logie , Majeke Busiwe , Mbongozi Xolani , Middleton Katrin , Naidoo Poovangela , Ndaba Sanele , Spence Trevi , Balie Gaynor M. , Monroy Angelica , Cantor Monica , Hofmeyr G. Justus 
Published: January 2025

AbstractObjectiveTo compare low‐cost “Suction Tube Uterine Tamponade” (STUT) treatment for refractory postpartum hemorrhage (PPH) with uterine balloon tamponade (UBT) using a randomized feasibility study.MethodsAfter verbal assent, we allocated participants with refractory PPH by randomly ordered envelopes to STUT or routine UBT at 10 hospitals in South Africa and one tertiary referral center in Colombia between January 10, 2020, and May 3, 2024. In the STUT group, we inserted a 24 FG Levin stomach tube into the uterine cavity and applied suction. The control group received standard UBT, mainly the Elavi free‐flow balloon or the Bakri fixed volume balloon. There were fundamental differences between the South African and the Colombian sites, so the pre‐specified analysis combined data from the two countries by meta‐analysis.ResultsWe enrolled 59 participants. The rate of the primary outcome (blood loss >1000 mL or laparotomy or death) was 8/27 (30%) in the STUT group versus 14/27 (52%) in the UBT group (risk ratio [RR] 0.56, 95% confidence interval [CI] 0.30–1.05, P = 0.07). Per protocol analysis was 7/26 (27%) versus 15/28 (54%) (RR 0.49, 95% CI 0.25–0.96, P = 0.04). Reporting severe pain during the procedures was less frequent in the STUT group (RR 0.46, 95% CI 0.25–0.86, P = 0.01). Most secondary outcomes favored the STUT group, with low certainty.ConclusionsSTUT was experienced as less painful than UBT. Results were consistent with reported observational findings and one other randomized trial evidence of greater effectiveness for suction than balloon tamponade.