bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes
Authors: Jelloul Emna , Sitoris Georgiana , Veltri Flora , Kleynen Pierre , Rozenberg Serge , Poppe Kris G 
Published: October 2023

Objective
The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes.

Methods
In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted- reproduction pregnancies, women with TSH levels >3.74 mIU/L, severe hyperthyroidism, treated for thyroid dysfunction before or after screening and gestational blood sampling <6 or >16 weeks of pregnancy. The prevalence of adverse pregnancy outcomes was compared between the study group sTSH (TSH: < 0.06 mIU/L; n = 36) and euthyroid controls (TSH: 0.06–3.74 mIU/L; n = 1045), and the impact of sTSH on pregnancy outcomes verified in logistic regression analyses.

Results
Median (IQR) serum TSH level in women with sTSH was 0.03 (0.03–0.03) vs 1.25 (0.81–1.82) mIU/L in controls and FT4 levels 18.0 (14.4–20.3) vs 14.2 (12.9–15.4) pmol/L; both P < 0.001. None of the women with sTSH had thyrotropin receptor antibodies. Compared with controls, the prevalence of TPOAb positivity (TAI) was comparable between groups (5.6% vs 6.6%; P = 0.803). The prevalence of maternal and neonatal pregnancy outcomes was comparable between the study and control group. The logistic regression analyses with corrections for TAI, FT4 and demographic parameters confirmed the absence of an association between sTSH, and the following outcomes: iron deficient anaemia (aORs (95% CI)): 1.41 (0.64-2.99); P = 0.385, gestational diabetes: 1.19 (0.44–2.88); P = 0.713, preterm birth: 1.57 (0.23–6.22);P = 0.574 and low Apgar-1′ score: 0.71 (0.11–2.67); P = 0.657.

Conclusions
Suppressed serum TSH levels during the first to early second trimester of pregnancy were not associated with altered maternal or neonatal outcomes.
PENGARUH SELF-EFFICACY GURU DAN KREATIVITAS GURU TERHADAP MOTIVASI BELAJAR SISWA DAN IMPLIKASINYA TERHADAP PRESTASI BELAJAR PADA MATA PELAJARAN EKONOMI
Authors: Adirestuty Fitranty , Wirandana Eri 
Published: October 2023

AbstractThe problem in this research is the declining student achievement in economic subjects seen from the UN (National Examination) SMA throughout Ciamis District. The method used was a survey, while technical analysis of test data using path analysis. Samples used as many as 33 teachers.The results showed that teachers’ self-efficacy and motivation to learn in the medium category, while the creativity of teachers in the low category.The conclusion of the study are (1) self-efficacy of teachers negatively affect students’ motivation, (2) creativity teachers have a positive influence on the students motivation, (3) self-efficacy of teachers have a positive influence on student achievement. (4) the creativity of teachers have a positive influence on student achievement. (5) students’ motivation negative effect on student achievement.AbstrakArtikel ini dilatarbelakangi oleh keprihatinan terhadap menurunnya prestasi belajar siswa pada Matapelajaran Ekonomi dilihat dari nilai UN (Ujian Nasional) anak-anak SMA Negeri se-Kabupaten Ciamis. Metode yang digunakan adalah survey, sedangkan teknis analisis data menggunakan uji path analysis. Sampel yang digunakan sebanyak 33 guru. Hasil penelitian menunjukkan bahwa (1) self-efficacy guru berpengaruh negatif terhadap motivasi belajar siswa, (2) kreativitas guru berpengaruh positif terhadap motivasi belajar siswa, (3) self-efficacy guru berpengaruh positif terhadap prestasi belajar siswa, (4) kreativitas guru berpengaruh positif terhadap prestasi belajar siswa. (5) motivasi belajar siswa berpengaruh negatif terhadap prestasi belajar siswa.Pengutipan: Adirestuty, F., Wirandana, E. (2016). Pengaruh Self-Efficacy Guru dan Kreativitas Guru terhadap Motivasi Belajar Siswa dan Implikasinya terhadap Prestasi Belajar pada Mata Pelajaran Ekonomi. SOSIO DIDAKTIKA: Social Science Education Journal, 3(2), 2016, 158-165. doi:10.15408/sd.v3i2.4017.Permalink/DOI: http://dx.doi.org/10.15408/sd.v3i2.4017
MENDIDIK PRIBADI BERKARAKTER “UWA HAENG WULANG, LANGKAS HAENG NTALA”
Authors: Lon Yohanes Servatius 
Published: October 2023

AbstractThis article is a socio-cultural comparative study on character education in general and the philosophy and local wisdom within the culture of Manggarai-NTT people that is “uwa haeng wulang, langkas haeng ntala” (grow up to the moon, and be high up to the sky). For the Manggaraian people, character education should be done optimally (maximally) in order to obtain highest achievement. The expectation is completed with strong personality as described in the phrase “wake caler ngger wa, saung bembang ngger eta” (be rooted in the deepest earth, and reach the outward world). By the comparison, character education in Indonesia will be easily implemented in local context. Moreover, the dialog between the two values will enrich the picture of character education in Indonesian.AbstrakArtikel ini merupakan suatu kajian sosio-budaya perbandingan antara konsep pendidikan karakter pada umumnya dengan filosofi dan kearifan lokal orang Manggarai yakni “uwa haeng wulang, langkas haeng ntala” (bertumbuh sampai ke bulan, tinggi sampai ke langit). Bagi orang Manggarai, pendidikan karakter tidak boleh dilakukan setengah-setengah atau sekadarnya saja. Pendidikan harus dibuat secara optimal agar tercapai cita-cita yang tinggi. Cita-cita itu dilengkapi dengan jati diri yang kokoh seperti dilukiskan dengan “wake caler ngger wa, saung bembang ngger eta” (pribadi yang berakar kuat/ke dalam dan berwawasan luas/ke luar). Melalui perbandingan ini, pendidikan karakter yang dicita-citakan oleh negara Indonesia lebih mudah dilaksanakan di dalam konteks lokal. Lebih dari itu, dialog keduanya dapat saling memperkaya wajah pendidikan karakter di Indonesia. Pengutipan: Lon, Y. S. (2016). Mendidik Pribadi Berkarakter “Uwa Haeng Wulang, Langkas Haeng Ntala”. SOSIO DIDAKTIKA: Social Science Education Journal, 3(2), 2016, 166-174. doi:10.15408/sd.v3i2.4387.Permalink/DOI: http://dx.doi.org/10.15408/sd.v3i2.4387
PROFIL KOMITMEN RELIGIUS DAN IMPLIKASINYA BAGI PENDIDIKAN
Authors: Aisyah Ade , Rohaniawati Dede , Gustini Neng 
Published: October 2023

AbstractThis study aims to determine differences in religious commitment and Teaching Faculty of SMA and MA (Pesantren) background, and its implications for learning. This research approach is quantitative descriptive and comparative techniques using questionnaires, the study documentation, and observation. The research data were analyzed using descriptive statistical analysis techniques and inferential. Research hypothesis testing using the comparative analysis is the t-score. The results showed that: there were significant differences of religious commitment among students of Faculty of SMA and MA (Pesantren) backgrounds. Obtained value t = -6.588 with df = 66 and p-value (2 sides / 2-tailed) = 0,000 so it can be concluded that the average score in the student questionnaire with SMA background, is smaller than MA (Pesantren) background. The results showed that there were differences in the profile dimensions religus commitment. First, the lack of communal dimension in the educational backgrounds of students MA (Pesantren). Second, high communal dimension in the educational backgrounds of students in SMA. Third, the dimensions of the experience both equally lacking. Fourth, the dimensions of both beliefs are equally high.AbstrakPenelitian ini bertujuan untuk mengetahui perbedaan komitmen religius mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA dan MA (Pesantren), serta implikasinya dalam pembelajaran. Pendekatan penelitian ini adalah kuantitatif dengan metode deskriptif dan teknik komparatif dengan menggunakan instrumen angket, studi dokumentasi, dan observasi. Data penelitian yang terkumpul dianalisis dengan menggunakan teknik analisis statistik deskriptif dan inferensial. Pengujian hipotesis penelitian menggunakan analisis komparasi yaitu t-score. Hasil penelitian menunjukkan bahwa: ada perbedaan yang signifikan tentang komitmen religius antara mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA dan MA (Pesantren). Didapat nilai t=-6,588 dengan dk=66 dan p-value (2 sisi/2-tailed)=0,000 sehingga dapat disimpulkan bahwa rata-rata skor angket di mahasiswa Fakultas Tarbiyah dan Keguruan yang berlatar belakang pendidikan SMA lebih kecil daripada MA. Hasil penelitian menunjukkan bahwa terdapat perbedaan profil dalam dimensi-dimensi komitmen religus. Pertama, kurangnya dimensi komunal pada mahasiswa yang berlatar belakang pendidikan MA (Pesantren). Kedua, tingginya dimensi komunal pada mahasiswa yang berlatar belakang pendidikan SMA. Ketiga, pada dimensi pengalaman keduanya sama-sama kurang. Keempat, pada dimensi keyakinan keduanya sama-sama tinggi. Pengutipan: Aisyah, A., Rohaniawati, D., Gustini, N. (2016). Profil Komitmen Religius dan Implikasinya Bagi Pendidikan. SOSIO DIDAKTIKA: Social Science Education Journal, 3(2), 2016, 175-183. doi:10.15408/sd.v3i2.4392.Permalink/DOI: http://dx.doi.org/10.15408/sd.v3i2.4392
Lipid metabolism disorders in patients with hypertension and diabetes mellitus: development and current treatment options
Authors: Podzolkov V. I. , Tarzimanova A. I. , Abramova A. A. , Vetluzhskaya M. V. , Medvedev I. D. , Loria I. Zh. 
Published: October 2023

The article presents the main mechanisms of development of lipid metabolism disorders and endothelial dysfunction in patients with hypertension (HTN) and type 2 diabetes (T2D), and their contribution to cardiovascular events. Modern approaches to the treatment of hypertension and dyslipidemia in people with type 2 diabetes are considered from the standpoint of the latest clinical guidelines, focusing on fixed-dose combinations as a means of an integrated approach to managing risk factors in comorbid patients. Data are presented on the efficacy and safety of fixed-dose combination of lisinopril, amlodipine and rosuvastatin in patients with hypertension and T2D.
Endothelial protective effect of pitavastatin
Authors: Berns A. S. , Kashtalap V. V. 
Published: October 2023

The article discusses topical issues of modern concepts of aging, including vascular aging due to the progression of endothelial dysfunction, atherogenesis, chronic and acute cardiovascular atherosclerosis-­related diseases. Modern potential of anti-aging therapy aimed at slowing the progression of vascular aging and endothelial dysfunction are reflected. A descriptive literature review was carried out based on the analysis of sources from the PubMed, eLibrary databases for the following keywords: endothelium, aging, pitavastatin, anti-aging effect (endothelium, aging, pitavastatin, anti-aging effect). Based on a review, the role of pitavastatin is shown not only as an effective cholesterol-­lowering drug, but also as an agent with a large number of proven pleiotropic effects, as well as an optimal safety profile and a low risk of side effects and drug interactions. On the example of a case, the potential of high-intensity lipid-­lowering therapy with the use of pitavastatin in a comorbid patient are illustrated.
BILATERAL INTERNAL THORACIC ARTERY GRAFTING: FIFTEEN YEARS OF EXPERIENCE
Authors: Frolov Alexey V. , Zagorodnikov Nikita I. , Ivanov Sergey V. , Tarasov Roman S. , Barbarash Leonid S. 
Published: October 2023

HighlightsBilateral internal thoracic artery (BITA) grafting is one of the most effective methods of direct myocardial revascularization. However, its results are still contradictory, despite the worldwide trend to use more autogenous arterial conduits.This study involves more than fifteen years of data in the use of BITA in Kuzbass in coronary artery disease surgery. The findings presented in the course of the analysis confirm the need to use both internal mammary arteries more actively. Aim. To analyze long-term results of BITA grafting in terms of more than 15 years follow-up.Methods. The study included 232 patients who were admitted at the Cardiac Surgery Department for coronary artery bypass grafting (CABG). All patients were divided into 2 groups depending on usage of single or bilateral internal thoracic artery conduits. Both groups included an equal number of patients 116 (50%). Long-term results were assessed in terms of more than 15 years follow-up.Results. BITA grafting is comparable with CABG in such major adverse cardiac and cerebrovascular events as repeated myocardial revascularization, stroke, and in combined endpoint such as myocardial infarction (MI), stroke, repeated myocardial revascularization, or patient’s death within 15 years. However, the BITA group is superior to the CABG group in freedom from MI, all-cause deaths, showing a higher life expectancy after surgery (p = 0.011), and improved left ventricular ejection fraction and decreased functional class of angina. Moreover, in the present research it was confirmed that the severity of atherosclerosis in the coronary arteries is lower after bypassing with autogenous arterial conduits.Conclusion. BITA is safe procedure comparable with CABG, however, it has more advantageous long-term clinical and angiographic results.
ECHOCARDIOGRAPHIC PREDICTORS OF ADVERSE CLINICAL EVENTS IN HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN COMBINATION WITH OBSTRUCTIVE SLEEP APNEA
Authors: Yakovlev Alexey V. , Efremov Ivan A. , Ryabikov Andrey N. , Yakovleva Natalia F. , Shirokikh Ilya V. , Shilov Sergey N. , Teplyakov Alexander T. , Grakova Elena V. , Kopeva Kristina V. 
Published: October 2023

HighlightsRepeated hospitalizations occupy a special place in adverse clinical events in heart failure, currently representing one of the most powerful predictors of adverse outcomes in this group of patients. Echocardiographic parameters such as longitudinal myocardial deformation, displacement in the annulus of the tricuspid valve, and left atrial volume index can serve as predictors of hospitalization for cardiovascular diseases in patients with heart failure with preserved ejection fraction and obstructive sleep apnea. Abstract Aim. To study the prognostic role of individual echocardiographic parameters in heart failure with preserved ejection fraction (HFpEF) in patients with arterial hypertension and obstructive sleep apnea (OSA).Methods. The study included 59 men with hypertension and OSA (apnea/hypopnea index >15 per hour). At baseline all patients underwent a sleep study and echocardiography with an additional assessment of the global longitudinal strain (GLS). Upon inclusion in the study and after 12 months of follow-up, a 6-minute walk test was performed. After 12 months, the clinical course of the disease was retrospectively assessed. The criteria for an adverse clinical course were episodes of hospitalization for cardiovascular diseases, the development of paroxysmal atrial fibrillation or high-grade ventricular arrhythmias (III–V class according to Ryan), worsening of heart failure with a transition to a higher functional class according to NYHA.Results. Significant differences were found in several echocardiographic parameters between the groups of patients with and without hospitalizations within 12 months of follow-up: tricuspid annular plane systolic excursion (TAPSE) (p = 0.017), GLS (p = 0.005), left atrial volume index (LAVI) (p = 0.032). According to the regression analysis results, TAPSE, GLS and left ventricular ejection fraction make a statistically significant contribution to the probability of hospitalizations among the evaluated echocardiographic predictors.Conclusion. The results of the study allow us to consider certain echocardiographic parameters, in particular GLS, TAPSE and LAVI, as predictors of hospitalizations in patients with HFpEF and OSA.
TYPE 2 MYOCARDIAL INFARCTION: A MODERN VIEW ON THE PROBLEM
Authors: Motova Anna V. , Karetnikova Victoria N. , Barbarash Olga L. 
Published: October 2023

HighlightsThe article describes the main differences between the types of myocardial infarction, in particular, differences between type 1 and type 2 myocardial infarction, the complexity of diagnosis and management of patients with myocardial infarction type 2, and summarizes data on the prevalence of patients with myocardial infarction type 2. The arguments supporting the need for further researches to differentiate various phenotypes of myocardial infarction are provided. AbstractDespite the high interest in the study of type 2 MI, many unresolved issues concerning diagnosis, criteria for diagnosis and, especially, therapeutic tactics remain unresolved. The available data regarding type 2 MI remain limited and inconsistent, and are based on sources that include the analysis of type 1 MI. According to various predictions, the prevalence of type 2 MI will increase even more. Type 2 MI management strategy should be patient-specific and in accordance with the etiology and pathogenesis, therefore, timely diagnosis, and MI differentiation according to universally accepted definitions is a relevant scientific topic and a practical necessity.Thus, summarizing all the above, we can say that type 2 myocardial infarction is a topic that encompasses many unresolved issues concerning diagnosis, patient management and further secondary prevention.
SIGNIFICANCE OF OPIOID, CANNABINOID, BRADYKININ RECEPTORS AND КАТP-CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF ADAPTATION TO COLD
Authors: Voronkov Nikita S. , Maslov Leonid N. , Bushov Yuri V. 
Published: October 2023

HighlightsIt has been shown that chronic adaptation to cold (28 days, +2 – +4°C) has a cardioprotective effect in in vivo model of myocardial ischemia/reperfusion injury in rats. Certain types of receptors and КАТP-channels might be involved in mechanisms of this effect. Aim. To evaluate the role of opioid, cannabinoid, bradykinin receptors and the КАТP-channels in the infarct-limiting effect of chronic adaptation to cold.Methods. The study involved male Wistar rats weighing 250–300 g. Rats (two in a cage) were placed in a refrigerator for 28 days. The temperature inside the chamber was +2 – +4oC. The infarct-limiting effect of chronic adaptation to cold and its possible cancelation by receptor blockers was studied in a 45-minute coronary artery occlusion and a 120-minute reperfusion of the rat myocardium in vivo. The quantitative assessment of myocardial injury was determined by the necrotic zone to the area at risk (NZ/AAR) ratio.Results. We have found that КАТP-channels are involved in the mechanism of the infarct-limiting effect of chronic adaptation to cold. Opioid, cannabinoid and bradykinin receptors are not involved in this effect.Conclusion. The obtained results have expanded our understanding of cold adaptation, as well as receptor pathways involved in the mechanism of ischemia/reperfusion injury resistance. Further studying of the signaling and receptor pathways of the infarct-limiting effect of cold adaptation will reveal molecules responsible for tolerance to ischemia/reperfusion injury. These molecules can be used to develop novel cardioprotective drugs for the treatment of acute myocardial infarction.
PREMATURITY AND THE MECHANICS OF THE INFANT HEART
Authors: Pavlyukova Elena N. , Kolosova Marina V. , Poddubny Vasily V. , Neklyudova Galina V. , Karpov Rostislav S. 
Published: October 2023

HighlightsThe differences in the postnatal ontogenesis of the heart in children from one to five years old born prematurely and with low, very low, and extremely low birth weight were revealed. The coexistence of different models in contractile-rotational processes of the left ventricle was demonstrated. AbstractAim. To expand the traditional ideas about the left ventricle (LV) mechanics formation processes in children born with low, very low and extremely low body weight in the postnatal period during the process of growth and development.Methods. The study was conducted in 237 children aged from one to five years old: 51 children born healthy and full-term (FT), 68 children born with low body weight (LBW) and 118 children born with very low (VLBW) and extremely low body weight (ELBW). The analysis of clinical, anamnestic data, indicators of standard echocardiography and LV mechanics was performed using discriminant analysis. To demonstrate the assessment of remoteness or proximity between clinical groups, the Mahalanobis distance was used. Visualization of the structure distribution of groups in a multidimensional feature space was carried out in the coordinates of the first two discriminant functions (canonical roots, canonical variables) of discriminant analysis. The evaluation of the discriminant functions significance was verified by Wilks statistics. Statistical analysis was performed on a personal computer using the Statistica program (version 12).Results. The most informative criteria for F (8.462) = 100,84 are “body weight at birth” (p = 0.000000), “character of feeding up to a year” (p = 0.000000) and direction of apex rotation (p = 0.0098).Conclusion. The use of discriminant analysis makes it possible to establish a change in the degree of the selected criteria influence on the level of differences between clinical groups, demonstrating fundamentally new aspects of a child's heart mechanics formation in the history of prematurity.
CARDIAC ONCOLOGY: A MODERN VIEW ON THE PROBLEM OF CHOOSING AN OPTIMAL STRATEGY FOR THE TREATMENT OF CORONARY ARTERY DISEASE AND CANCER
Authors: Alekyan Bagrat G. , Karapetyan Narek G. , Gritskevich Aleksandr A. , Gyoletsyan Lilit G. , Galstyan Arthur V. , Revishvili Amiran Sh. 
Published: October 2023

HighlightsThe article presents an overview of the main studies on the treatment of patients with coronary artery disease and cancer. Abstract Cardiovascular and oncological diseases remain the leading causes of death globally. The combination of coronary artery disease and cancer is becoming more common in clinical practice. Despite the achievements in the treatment of both of these diseases separately, their combination is a considerable issue for specialists. This review article discusses the main issues of managing patients with cancer and coronary artery disease. Moreover, the article presents various treatment strategies, including simultaneous and step-by-step interventions, and shows the current trends of endovascular approach to the treatment of these patients.
SKS Polarization Anomalies Due to the Coriolis Force
Authors: Creasy Neala , Bozdağ Ebru , Frost Daniel A. , Snieder Roel 
Published: October 2023

ABSTRACT
The Earth’s Coriolis force has been well-known to impact surface waves and normal modes, which is essential to accurately interpret these waves. However, the Coriolis force on body waves has been assumed to be negligible and mostly ignored. It has been previously shown that the Coriolis force impacts polarizations of shear waves, whereas the wavefronts remain unaffected. We expand on the potential influences of Earth’s Coriolis force on shear-wave polarization measurements by conducting 3D numerical simulations for elastic waves generated by earthquake and explosive sources in a radially symmetric, and 3D mantle and crustal models. The Coriolis force can produce polarization anomalies of mantle shear waves up to 7° and core phases, such as SKS and SKKS, up to 4°. Uncorrected shear-wave polarizations due to the Coriolis force can cause an additional source of error (5°–10° in fast direction, and 0.2–0.3 s delay time depending on the method and seismic phase), inaccurate interpretation of station misalignments, and imprecise estimates of the core–mantle boundary topography. We show how to correct for the Coriolis force on teleseismic shear waves using 1D ray tracing for well-isolated phases. We recommend the use of full waveform simulations to accurately account for earthquake sources parameters, poorly isolated phases that could include interfering phase arrivals within the measurement time window, and the effect of the Coriolis force on the polarizations of shear waves.