bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferulic acid reduces GLP‐1 degradation to ameliorate diet‐induced obesity‐associated hepatic steatosis
Authors: An Yuxuan , Zhang Lichao , Fan Xiaxia , Cui Kaili , He Shuiling , Ji Pengyu , Tian Jinmiao , Li Zhuoyu 
Published: January 2024

AbstractGLP‐1 is a vital candidate for stimulating insulin secretion in a glucose‐dependent manner, reducing body weight and eliminating nonalcoholic fatty liver disease with few side effects. Therefore, elevating GLP‐1 secretion and antagonizing the enzymatic cleavage by DPP4 are the main direction of GLP‐1‐based drug development. The present study implies that ferulic acid (FA) treatment increased the serum GLP‐1 level in diet‐induced obesity mice. The binding of FA to GLP‐1 effectively prevented the enzymatic cleavage of GLP‐1 by DPP4, which led to the effective elimination of hepatic cellular lipids by GLP‐1 in vitro. Furthermore, studies of fluorescence titration and molecular simulation showed that the combination ratio of FA and GLP‐1 was 1:1, and FA could enhance the stability of GLP‐1 through van der Waals force and electrostatic force binding to GLP‐1. In turn, it increased the level of endogenous GLP‐1. More importantly, data from mass spectrometry analysis revealed that FA bound to GLN‐17, ALA‐18, or ALA‐19 sites of GLP‐1 differently. In addition, after binding to FA, the α‐helix in GLP‐1 did not change significantly, and the biological activity of GLP‐1 was unaffected. These results highlight that FA‐rich food, such as millet and oats, is an excellent source of dietary intervention for metabolic disorders.
Recent trends in the application of films and coatings based on starch, cellulose, chitin, chitosan, xanthan, gellan, pullulan, Arabic gum, alginate, pectin, and carrageenan in food packaging
Authors: Rostamabadi Hadis , Demirkesen Ilkem , Colussi Rosana , Roy Swarup , Tabassum Nazia , de Oliveira Filho Josemar Gonçalves , Bist Yograj , Kumar Yogesh , Nowacka Małgorzata , Galus Sabina , Falsafi Seid Reza 
Published: January 2024

AbstractThe inevitable drawbacks of petrochemical polymer‐based packaging (e.g., extreme loss of fossil resources, excessive products’ carbon footprint, and inordinate environmental pollution resulting from the accumulation of disposed nonbiodegradable plastic‐based packages) have urged scientists to develop novel packaging materials from nature‐inspired biopolymers. Due to their biodegradability, non‐toxicity, film‐forming ability, and barrier properties versus gasses/aroma, polysaccharides have been increasingly valued in developing food packaging materials at the lab or industrial scale. Nonetheless, these valuable biopolymers also suffer from some inherent deficiencies, that is, low resistance to water and poor mechanical attributes. Hitherto, tackling such bottlenecks via the modification of biopolymers through chemical/physical approaches and applying a combination of several biopolymers has been the main focus of numerous recent studies. In this context, the present article, for the first time, provides a comprehensive update on the most recent utilization of common polysaccharides (e.g., starch, chitosan, xanthan gum, gum Arabic, alginate, gellan, pectin, and carrageenan) for food packaging applications.
Selective Recognition of Aromatic Amino Acids by a Molecular Cleft in Water
Authors: Keller Joël F. , Valášek Michal , Mayor Marcel 
Published: January 2024

AbstractThe development of water‐soluble hosts for the selective recognition of aromatic amino acids is highly desirable and may serve as a tool to facilitate drug discovery and enable fabrication of sensors for point‐of‐care monitoring in the context of phenylketonuria disease. This paper presents the synthesis and characterization of a water‐soluble molecular cleft which is demonstrated to selectively bind aromatic amino acid guests over other amino acids in aqueous medium, favoring ʟ‐Trp over ʟ‐Phe and ʟ‐Tyr by a factor of approximately five. Host/guest‐interaction forces were studied by 1H‐NMR titrations complemented by fluorescence titrations and isothermal titration calorimetry. The here presented results provide a starting point for future optimizations in our efforts to selectively identify and quantify individual aromatic amino acids in aqueous medium.
Thermo‐hydraulic performance investigation of solar air heater duct having staggered D‐shaped ribs: Numerical approach
Authors: Dutt Nitesh , Hedau Ankush , Kumar Ashwani , Awasthi Mukesh Kumar , Hedau Sachin , Meena Chandan Swaroop 
Published: January 2024

AbstractThe thermohydraulic performance (THP) of a solar air heater (SAH) duct with staggered D‐shaped ribs as roughness geometry is examined in this work using three‐dimensional numerical investigation. The investigation is carried out at roughness parameters of radius of rib to transverse pitch (r/Ptv) ratios of 0.1–0.35 and longitudinal pitch to radius of rib (Plg/r) ratios of 4–10 under varied operating circumstances of Reynolds number (Re) from 10,200 to 20,200. The maximum Nusselt number (Nu) is obtained to be 81.3 at Re of 20,200, r/Ptv as 0.1, and Plg/r as 4. In contrast, the maximum friction factor (f) is obtained to be 0.0169 at Re of 10,200, r/Ptv as 0.35, and Plg/r as 4. In the range of parameters examined, the maximum enhancement in Nusselt number (Nu/Nus) is observed to be 1.35 at an optimal parameter of r/Ptv as 0.1, Plg/r as 4, and Re as 10,200. Correspondingly, the enhancement in the friction factor (f/fs) at this optimum parameter is 1.87. The maximum value of the THP parameter is found to be 1.1 at the same optimum range of parameters. In further analysis, correlations were developed for Nusselt number (Nu) and friction factor (f) in terms of r/Ptv, Plg/r, and Re with a deviation of ±2% and ±1.5%, respectively.
Enhancing heat transfer in MHD Falkner's‐Skan flow with thermal radiation, free convection and dusty fluid between parallel plates
Authors: Khan Dolat , Ali Gohar , Ghazwani Hassan Ali 
Published: January 2024

AbstractFalkner's‐Skan flows are one‐dimensional flows widely used in fluid dynamics and boundary layer theory. They optimize heat exchangers and cooling systems, enhance turbine and compressor blades in turbomachinery, and provide consistency and quality in semiconductor fabrication. Additionally, they assist in pollution management and environmental impact assessments. The variety of Falkner's‐Skan flows clarifies fluid flow phenomena and their practical applications. This article aims to explore the impact of surface temperature on the flow behavior of dusty fluid in Falkner's‐Skan flow. The study focuses on the flow of dust particles in a channel formed by two infinite parallel plates. The study assumes that the particles are round and uniformly dispersed in the fluid. Furthermore, the article takes into account the effect of radiation on the energy equation. With the findings of this study, we hope to gain a better understanding of the dynamics of Falkner's‐Skan flow and contribute to the development of effective strategies for managing the flow of dusty fluids. The right plate's movement at free stream velocity causes the fluid to flow. Partial differential equations are used to represent the behavior of the flow. The Poincare‐Light Hill Technique yields exact answers. Visual representations of the temperature and velocity curves show the effects of different factors. It is possible to create graphic pictures of the fluid and dust particles using Mathcad‐15. Furthermore, critical fluid characteristics for engineers, such as skin friction and heat transfer rate, are analyzed and tabulated. These evaluations include the heat transfer rate at the wedge surface and the influence of this enhancement on surface viscous drag forces.
Cost‐effectiveness analysis of cell‐based versus egg‐based quadrivalent influenza vaccines in the pediatric population in Taiwan
Authors: Chi Chia‐Yu , Cheng Ming‐Fang , Ko Karam , Mould Joaquin F. , Chen Chih‐Jung , Huang Yhu‐Chering , Lee Ping‐Ing 
Published: January 2024

AbstractCell‐based influenza vaccines avoid egg‐adaptive mutations, potentially improving vaccine effectiveness. We assessed the one‐season cost‐effectiveness of cell‐based quadrivalent influenza vaccine (QIVc) against that of egg‐derived quadrivalent influenza vaccines (QIVe) in children (6 months to 17 years of age) from payer and societal perspectives in Taiwan using an age‐stratified static model. Base case and high egg adaptation scenarios were assessed. Deterministic and probabilistic sensitivity analyses were performed. The incremental cost‐effectiveness ratio (ICER) threshold in Taiwan was assumed to be USD 99 177/quality‐adjusted life year (QALY). Compared to QIVe, QIVc would prevent 15 665 influenza cases, 2244 complicated cases, and 259 hospitalizations per year. The base case ICER was USD 68 298/QALY and USD 40 085/QALY from the payer and societal perspective, respectively. In the high egg adaptation scenario, the ICER was USD 45 782/QALY from the payer's perspective and USD 17 489/QALY from the societal perspective. Deterministic sensitivity analyses indicated that infection incidence rate, vaccination coverage, and prevalence of the A/H3N2 strain were the main drivers of ICER. In conclusion, switching the immunization strategy from QIVe to QIVc is predicted to reduce the influenza‐associated disease burden and be cost‐effective for the pediatric population in Taiwan. The potential benefits of QIVc would be even higher during influenza seasons with high levels of egg adaptation.
Surgery for female urethral stricture
Authors: Bouchard Béatrice , Campeau Lysanne 
Published: January 2024

AbstractBackgroundFemale urethral stricture (FUS) is a rare entity that causes great morbidity and suffering in those affected. As the available scientific data is sparce, there are no formal guidelines or standard of care for this disease.MethodsThis is a narrative review of the surgical management for female urethral stricture. The literature review was performed on PubMed. Articles were limited to English, but there was no limitation in terms of date.ResultsManagement of FUS is divided between endoscopic and open surgical repair. Urethral dilation with or without urethrectomy can be offered as a first‐line treatment. However, the rate of success of this procedure remains inferior to open surgical repair, and its efficacy decreases with the number of previous dilations. For distal urethral strictures, distal urethrectomy and advancement meatoplasty may be considered. Vaginal flaps are readily available, easy to harvest, well‐vascularized, and allow for a dorsal or ventral orientation urethroplasty. The results of this procedure are promising, but most studies are small and retrospective. Labia flaps are easily accessible, wet, hairless, and elastic. The main limitations with the use of vaginal or labial tissues are co‐existing conditions such as lichen sclerosis or vaginal atrophy, which may affect future results. Vaginal and labial graft urethroplasty can be used when it is not possible to mobilize an adequate flap. Stricture‐free rates of this technique are variable. In cases of more severe stricture, an augmentation urethroplasty using buccal mucosa graft may be necessary. The techniques used in FUS replicate those for male urethral strictures, where both ventral and dorsal approaches can be utilized.ConclusionsAlthough there is growing interest in the field, the optimal management of FUS remains to be determined.
Aspects of image data preparation to extend a classification scheme for cleaning mechanisms to realistic soils
Authors: Golla Christian , Boddin Ludwig , Köhler Hannes , Rüdiger Frank , Fröhlich Jochen 
Published: January 2024

AbstractKnowledge of the cleaning mechanism is necessary to choose a suitable model for a cleaning simulation. In the present work, an existing classification scheme for cleaning mechanisms is considered. Altough this framework is quite promising, the generation of training data constitutes a bottleneck, since the labeling was done manually and very roughly in order to supply the necessary amount of samples in a reasonable time. This, in turn, causes the scheme to be inaccurate when applied to more realistic data. The aim of the present work is to improve the preparation of training data preparation by introducing a semi‐automatic labeling procedure. The labeling procedure involves a new perspective on the data and the application of a gradient filter procedure. Furthermore, fully convolutional networks (FCNs) are employed to generalize different gradient filter. The labeling procedure is significantly faster and more consistent than manual labeling. Also, a proof of concept is provided showing that the FCNs are a suitable technique for the present classification task.
A hypothetic model for examining the relationship between savoring, imagination, perceived hope and resilience: A study of Taiwanese principals
Authors: Cheng Yao‐Chung 
Published: January 2024

AbstractSchool principals are integral to the success of school operations, particularly in the face of diverse challenges. Resilience emerges as a critical attribute for these educational leaders. This research investigated the sequential mediation effects of imagination and perceived hope on the relationship between savoring and resilience. A survey was conducted with 1306 principals (390 females and 916 males; 302 from senior high schools, 351 from junior high schools, and 653 from elementary schools), representing 34% of the total population. Utilizing Partial Least Squares Structural Equation Modeling, the analysis revealed that: (1) savoring positively correlates with resilience, (2) imagination significantly mediates the relationship between savoring and resilience, (3) perceived hope significantly mediates the relationship between savoring and resilience, and (4) imagination and perceived hope sequentially mediate the relationship between savoring and resilience. The research concludes by discussing the theoretical and educational implications of these findings and proposes directions for future research.
Insights from autonomy trials of a self‐reconfigurable floor‐cleaning robot in a public food court
Authors: Wijegunawardana I. D. , Muthugala M. A. Viraj J. , Samarakoon S. M. Bhagya P. , Hua Ong Jun , Padmanabha Saurav Ghante Anantha , Elara Mohan Rajesh 
Published: January 2024

AbstractAs autonomous cleaning robots advance, we expect certain features, such as higher area coverage and robustness. To explore these features and their challenges, we need tools and strategies that allow us to develop them rapidly. In this paper, we present lessons learned and results while performing 3 months long field trials on the autonomy of a self‐reconfigurable floor‐cleaning robot. The autonomy here includes path planning and navigation of the robot for coverage in a public food court. The environment of the food court is often subjected to alterations due to human activities. One of the main contributions of this paper is proposing a task‐level execution system to deploy the cleaning robot in an actual use case scenario. We also provide in‐depth discussions on the solutions and the implementation strategies we found in accomplishing goals. These findings would be helpful in conducting autonomy development targeted for field deployments of self‐reconfigurable robots and cleaning robots.
Detection of Amaranth and Iron in Foods by Modified Carbon Quantum Dots as a Ratiometric Fluorescence Probe
Authors: Hu Qingqing , Kuang Jianhua , Yuan Jingxue , Feng Yao , Cheng Zhengjun 
Published: January 2024

AbstractIn this work, a new carbon quantum dots (CDs) was prepared though microwave assisted approach using citric acid anhydrous (CA) and N‐[3‐(Trimethoxysilyl)propyl] ethylenediamine (TPED) as raw materials. However, the CDs was not effective in actual sensing applications, so further modification of CDs was done by 3,5‐Dichloro‐2‐hydroxybenzaldehyde (it was named as G‐CDs). Fortunately, the modified CDs (G‐CDs) has good selectivity for Fe3+ and amaranth. Studies confirmed that Fe3+ could quench the fluorescence of G‐CDs by forming a complex, while the fluorescence quenching mechanism of G‐CDs by amaranth (AM) mainly belonged to the internal filtering effect (IFE). A detection limit of 20.8 nM for Fe3+ and 43.8 nM for AM were achieved. Moreover, the as‐developed G‐CDs probe was also successfully used to detect Fe3+ and amaranth in real samples, and compared with their results by the standard method, hinting that the accuracy and reliability of the probe were highly satisfactory.
Investigation of nanofiltration systems efficiency for removal of chromium and copper from groundwater resources
Authors: Jalali Seyed Homam Seyed 
Published: January 2024

AbstractThere is a vital need and constraint for providing water of good quality all around the world. Thus, with the aim of groundwater treatment, different methods of water treatment have been reviewed. Considering modern methods of membrane filtration, in this study efficiency of nanofiltration for removing heavy metals (copper and chromium) has been examined. The investigation has been accomplished in two separate phases for removing copper and chromium. To prepare the samples of groundwater, urban waters have been utilized and for preparation of chromium‐contaminated and copper‐contaminated waters, powder of chromium‐oxide and powder of copper sulfate pentahydrate have been added into samples, respectively. In this research, system‐operating pressure has been changed, while concentration and pH were kept constant. The effect of pressure on the efficiency of heavy metals removal has been checked and optimum pressure of the process has been achieved. Then, with optimal pressure as system operating pressure, the removal of heavy metals in different pH have been checked and accordingly, the optimal pH for the process was obtained. The Optimum Pressure and pH for chromium and copper are 7.5 bars and 6.3, and 7.5 bars and 6.7, respectively. Taking into account the result of this study, Nano filtration is a suitable method with high efficiency (90% and higher in optimum pressure and pH) for the removal of heavy metals from groundwater.
Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice
Authors: Dzik Katarzyna Patrycja , Flis Damian Józef , Kaczor-Keller Katarzyna Barbara , Bytowska Zofia Kinga , Karnia Mateusz Jakub , Ziółkowski Wiesław , Kaczor Jan Jacek 
Published: January 2024

Abstract
Amyotrophic lateral sclerosis (ALS) may result from the dysfunctions of various mechanisms such as protein accumulation, mitophagy, and biogenesis of mitochondria. The purpose of the study was to evaluate the molecular mechanisms in ALS development and the impact of swim training on these processes. In the present study, an animal model of ALS, SOD1-G93A mice, was used with the wild-type mice as controls. Mice swam five times per week for 30 min. Mice were analyzed before ALS onset (70 days old), at ALS 1 disease onset (116 days old), and at the terminal stage of the disease ALS (130 days old), and compared with the corresponding ALS untrained groups and normalized to the wild-type group. Enzyme activity and protein content were analyzed in the spinal cord homogenates. The results show autophagy disruptions causing accumulation of p62 accompanied by low PGC-1α and IGF-1 content in the spinal cord of SOD1-G93A mice. Swim training triggered a neuroprotective effect, attenuation of NF-l degradation, less accumulated p62, and lower autophagy initiation. The IGF-1 pathway induces pathophysiological adaptation to maintain energy demands through anaerobic metabolism and mitochondrial protection.

Graphical Abstract

Key messages

The increased protein content of p62 in the spinal cord of SOD1-G93A mice suggests that autophagic clearance and transportation are disrupted.

Swim training attenuates neurofilament light destruction in the spinal cord of SOD1-G93A mice.

Swim training reducing OGDH provokes suppression of ATP-consuming anabolic pathways. Swim training induces energy metabolic changes and mitochondria protection through the IGF-1 signaling pathway.
Induced oscillatory brain responses under virtual reality conditions in the context of repetition priming
Authors: Kisker Joanna , Johnsdorf Marike , Sagehorn Merle , Schöne Benjamin , Gruber Thomas 
Published: January 2024

AbstractIn the human electroencephalogram (EEG), induced oscillatory responses in various frequency bands are regarded as valuable indices to examine the neural mechanisms underlying human memory. While the advent of virtual reality (VR) drives the investigation of mnemonic processing under more lifelike settings, the joint application of VR and EEG methods is still in its infancy (e.g., due to technical limitations impeding the signal acquisition). The objective of the present EEG study was twofold. First, we examined whether the investigation of induced oscillations under VR conditions yields equivalent results compared to standard paradigms. Second, we aimed at obtaining further insights into basic memory-related brain mechanisms in VR. To these ends, we relied on a standard implicit memory design, namely repetition priming, for which the to-be-expected effects are well-documented for conventional studies. Congruently, we replicated a suppression of the evoked potential after stimulus onset. Regarding the induced responses, we observed a modulation of induced alphaband in response to a repeated stimulus. Importantly, our results revealed a repetition-related suppression of the high-frequency induced gammaband response (>30 Hz), indicating the sharpening of a cortical object representation fostering behavioral priming effects. Noteworthy, the analysis of the induced gammaband responses required a number of measures to minimize the influence of external and internal sources of artefacts (i.e., the electrical shielding of the technical equipment and the control for miniature eye movements). In conclusion, joint VR–EEG studies with a particular focus on induced oscillatory responses offer a promising advanced understanding of mnemonic processing under lifelike conditions.