bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrogenesis of the Early Paleozoic Dioritic–Granitic Magmatism in the Eastern North Qilian Orogen, NW China: Implications for Tethyan Tectonic Evolution
Authors: Xue Fei , Yang Fan , Ren Weidong , Santosh M. , Qian Zesheng , Huang Yin , Tan Zijian 
Published: February 2024

Abstract
The North Qilian Orogen witnessed the opening, subduction, and closure of the Proto-Tethys Qilian Ocean and the post-subduction of multiple exhumation events from Late Neoproterozoic to Early Paleozoic. The Early Paleozoic dioritic–granitic magmatic suites, prominently exposed in the eastern North Qilian Orogen, offer valuable insights into the evolution of the Proto-Tethys Ocean. However, their petrogenesis, magma source, and tectonic evolution remain controversial. Here, we investigate the Leigongshan, Zhigou, and Dalongcun intrusions and present geochronological, geochemical, and isotopic data, aiming to refine the comprehension of their timing and petrogenesis, which will contribute to understanding the tectonic evolution of the Proto-Tethys Ocean. Zircon U-Pb dating reveals mean ages of 471–427 Ma for these intrusions, consistent with compiled formation ages of dioritic–granitic intrusions in the eastern North Qilian Orogen, indicating close temporal links with the tectonic evolution of the Proto-Tethys Ocean during the Early Paleozoic. The studied magmatic rocks could be categorized into two major types: granitoids and diorites. The granitoids are majorly I-type granitoids that are generated through partial melting of the mafic lower crust and fractional crystallization at the middle-upper crust, with the involvement of mantle-derived materials. The diorites underwent limited crustal contamination and fractionation of hornblende, plagioclase, and some accessory minerals. They were derived mainly from the mixture of fertile mantle and reworked crustal components, with minor contributions from subduction-related slab fluids and sediment melts. In addition, all the studied Early Paleozoic dioritic–granitic intrusions (ca. 471–427 Ma) formed within subduction-related arc settings. Combined with the tectonic evolution of the Early Paleozoic Qilian orogenic system, we interpret these Cambrian to Silurian dioritic–granitic intrusions as tectonic responses to the subduction (ca. 520–460 Ma) and closure (~440 Ma) of the Proto-Tethys Ocean, whereas the Devonian Huangyanghe intrusion witnessed the final stage of extensional collapse of the Qilian orogenic system at ca. 400–360 Ma.
Challenging Error Correction in Recognised Byzantine Greek
Authors: Pavlopoulos John , Kougia Vasiliki , Arias Esteban Garces , Platanou Paraskevi , Shabalin Stepan , Liagkou Konstantina , Papadatos Emmanouil , Essler Holger , Camps Jean-Baptiste , Fischer Franz 
Published: February 2024

Abstract
Automatic correction of errors in Handwritten Text Recognition (HTR) output poses persistent challenges yet to be fully resolved. In this study, we introduce a shared task aimed at addressing this challenge, which attracted 271 submissions, yielding only a handful of successful approaches. This paper presents the datasets, the most effective methods, and an experimental analysis in error-correcting HTRed manuscripts and papyri in Byzantine Greek, the language that followed Classical and preceded Modern Greek. By using recognised and transcribed data from seven centuries, the two best-performing methods are compared, one based on a neural encoder-decoder architecture and the other based on linguistic knowledge. We show that the recognition error rate can be reduced by both, up to 2.5 points at the level of characters and up to 15 at the level of words, while also elucidating their respective strengths and weaknesses.
Variable-Density Velocity-Selective Magnetization Preparation for Non-Contrast-Enhanced Peripheral MR Angiography
Authors: Kim Minyoung , Hwang Inpyeong , Choi Seung Hong , Park Jaeseok , Shin Taehoon 
Published: February 2024

Abstract

Velocity-selective (VS) magnetization preparation has shown great promise for non-contrast-enhanced (NCE) magnetic resonance angiography (MRA) with the ability to generate positive angiographic contrast directly using a single 3D acquisition. However, existing VS-MRA methods have an issue of aliased saturation around a certain velocity, known as velocity field-of-view (vFOV), which can cause undesired signal loss in arteries. This study aimed to develop a new version of the VS preparation pulse sequence that overcomes the aliased saturation problem in conventional VS preparation. Utilizing the fact that an excitation profile is the Fourier transform of excitation k-space sampling, we sampled the k-space in a non-uniform fashion by scaling gradient pulses accordingly to have aliased excitation diffused over velocity. The variable density sampling function was numerically optimized to maximize the average of the velocity passband signal while minimizing its variance. The optimized variable density VS magnetization was validated through Bloch simulations and applied to peripheral NCE MRA in healthy subjects. The in-vivo experiments showed that the proposed variable density VS-MRA significantly lowered arterial signal loss observed in conventional VS-MRA, as evidenced by a higher arterial signal-to-noise ratio (58.50 ± 14.29 vs. 55.54 ± 12.32; p < 0.05) and improved artery-to-background contrast-to-noise ratio (22.75 ± 7.57 vs. 20.60 ± 6.51; p < 0.05).
Value of peripheral blood ratio in diagnosis and prognosis prediction of sinonasal squamous cell carcinoma Running title: Peripheral blood ratio in SNSCC
Authors: Wang Tian , Zhang Qi , Wang Li , Wang Jie , Song Xinmao 
Published: February 2024

Abstract

Sinonasal squamous cell carcinoma (SNSCC) usually presents at an advanced stage by the time of diagnosis, and there is still a lack of indicators to predict the prognosis of SNSCC patients. We aim to investigate whether the peripheral blood ratios might be good options for predicting the progress in patients with SNSCC. We performed a retrospective analysis on 198 patients with SNSCC and 63 healthy people as the normal control people (NCP) between January 2010 and December 2022. Systemic inflammatory response index (SIRI), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (LMR) were calculated. We compared the differences in these four peripheral blood ratios between the NCP and SNSCC patients and investigated the predictive value for the prognosis of SNSCC patients. SIRI, LMR, NLR, and PLR differed significantly between the NCP and SNSCC patients (P < 0.05). NLR (Area Under Curve, AUC: 0.813) had a higher diagnostic sensitivity than SIRI, LMR, and PLR for SNSCC patients. Multivariate cox-regression showed that high LMR was associated with poor prognosis. The values of NLR, SIRI, LMR, and PLR can be used as parameters for the auxiliary diagnosis and prognosis of SNSCC. In SNSCC patients, LMR is a sensitive factor in predicting OS and DMFS.
Identification of potential prognostic genes associated with the tumor microenvironment in chromophobe renal cell carcinoma based on weighted gene co-expression network analysis
Authors: Li Fangfang , Wang Siyuan , Hu Huiqing , Zhang Jie , Yu Helong , Zhong Fei 
Published: February 2024

Abstract

Background Chromophobe renal cell carcinoma (ChRCC) is the third prevalent type of renal cell carcinoma(RCC), making up 5% of all RCCs. The objective of this study was to define prognostic genes associated with the tumor microenvironment (TME) of ChRCC.
Methods Calculation of immune and stromal scores for ChRCC samples in the TCGA database using ESTIMATE algorithm. The differentially expressed genes (DEGs) were selected to construct co-expression modules by weighted gene co-expression network analysis(WGCNA), and hub modules were definited by calculating module-trait correlations to obtain TME-related DEGs. After that, we further analyzed the biological and molecular functions of these TME-related DEGs and evaluated their prognostic values. Finally, the online TIMER database was used to explore the infiltration of immune cells.
Results 468 DEGs were identified based on stromal scores and immune scores, of which 442 were upregulated genes and 26 were down-regulated genes. Subsequently, the 122 overlapping genes were predicted from WGCNA, and considered as TME-related genes. After analyzing by Molecular Complex Detection (MCODE) plugin from Cytoscape software, Functional enrichments analysis showed that TME-related genes in primary modules were associated with immune responses or inflammatory. Consequently, six TME-relate genes (ALOX5, FGR, GRASP, HLA-DQA1, HLA-DRB1, and ROBO4) were found to be correlated with overall survival of ChRCC and immune cells infiltration.
Conclusion We further analyzed the results by UALCAN databases, and combined with the IHC results of three specimens diagnosed with CHRCC, and finally found that the TME-relate ALOX5 may be a potential biomarker for the prognosis of ChRCC
RANKL/RANK signaling recruits Tregs via CCL20/CCR6 pathway and promotes stemness and metastasis in colorectal cancers
Authors: Zhu Chengming , Ouyang Jing , Hu Shuang , Zhu Qingqing , Kang Tingting , Xie Wenlin , Wang Yun , Li Yan , Lu Yingsi , Qi Jinhua , Li Chenxin , Yang Yingqian , Sun Yazhou , Gao Tianshun , Ye Liping , Liang Qian , Pan Yihang 
Published: February 2024

Abstract

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in a number of malignancies. The clinical importance of RANKL/RANK in colorectal cancer (CRC) is, however, mainly unknown. We examined CRC patient samples and found that RANKL/RANK was elevated in CRC tissues as compared to nearby normal tissues. A higher RANKL/RANK expression was related with a worse survival rate. Furthermore, we found that RANKL is mostly produced by regulatory T cells (Tregs), which can promote CRC advancement. Overexpression of RANK or addition of RANKL significantly increased the stemness and migration of CRC cells. Furthermore, RANKL/RANK signaling stimulates C-C motif chemokine ligand 20 (CCL20) production by CRC cells, which leads to Treg recruitment, boosting tumor stemness and malignant progression. This recruitment process was accomplished by using CCL20-CCR6 interaction, demonstrating a connection between CRC cells and immune cells. These findings suggest that RANKL/RANK plays an important role in CRC progression and could be a potential target for CRC prevention and therapy.
Extraction and physical characterization of a novel cellulosic fiber derived from the bark of daphne Gnidium plant
Authors: Issasfa Brahim , Latreche Ameur , Guebailia Moussa , Aloui Amel 
Published: February 2024

Abstract
The primary aim of this research is to develop a method for extracting fibers from the bark of the Daphne Gnidium shrub for use in various fields, such as paper manufacturing and reinforcing composite materials with plant fibers. These plant fibers have gained significant attention and are increasingly utilized in automotive, infrastructure, and renewable material-based sectors. Following the extraction of Daphne Gnidium bark fibers using the method outlined in this study, we analyzed their morphological, chemical, and physical properties in samples of the biofibers, locally known as Lazaz. The characteristics (physical, chemical, and morphological structure) revealed in this research align with numerous other studies, particularly in terms of density. We also consider the economic and environmental contexts of local natural products in Algeria, prompting us to undertake comprehensive studies in the environmental field to identify new types of useful plants that can contribute to technological development.
WITHDRAWN: Creating Highly Efficient Stretchable OLEDs with Nanowavy Structures for Angle-Independent Narrow Band Emission
Authors: Suh Min Chul , Nimbalkar Ajay , Irfan Aqsa 
Published: February 2024

Abstract

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Optimal Cut-off Value of Ultrasound Double Contour Sign Combined with Serum Uric Acid in Gout
Authors: Wu Jinyu , Liu Shanna , Yan Junliang , Chang Jie , Fei Shiyin , Wu Xuan , Shi Jianing , Li Chang , Xia Bin , Zhou Qingli , Zhu Xinjian 
Published: February 2024

Abstract
Objectives. We searched for the optimal cut-off value of the ultrasound double contour (DC) sign and the value of the DC sign combined with serum uric acid (SUA) for diagnosing gout.
Methods. Gout patients, rheumatoid arthritis or osteoarthritis patients (RA/OA group), and healthy individuals were included in this study based on the inclusion criteria. SUA and the length of the DC sign in the knee and were detected and compared. The optimal cut-off values for diagnosing gout by DC sign and SUA were analyzed using the receiver operating characteristic (ROC) curve. We also plotted the ROC curve to compare the value of the ultrasound DC sign, SUA, and DC sign combined with SUA (in parallel and in series).
Results.In this study, we included 330 subjects (n = 110 in the gout group, 110 in the RA/OA group, and 110 in the healthy control group). The optimal cut-off value of the DC sign for the diagnosis of gout was 1.67 cm. The results of the ROC curve analysis showed that the DC sign in parallel SUA had the highest diagnostic value (1.67 cm), which was higher than the value recorded in combined detection based on the presence or absence of the DC sign.
Conclusions. The optimal cut-off value of the ultrasound DC sign for diagnosing gout was 1.67 cm; below this cut-off value, the DC sign in parallel SUA had the highest diagnostic value for gout and provided a reliable basis for the efficient diagnosis of gout.
Migration of Cervical Spine Screws to the Sacral Canal: A Case Report
Authors: Fang Miao , Zeng Yong , Song Yueming 
Published: February 2024

Abstract

Cervical open door laminoplasty is widely used in multilevel decompression, which is a motion-sparing decompression treatment option for multilevel cervical myelopathy. Implant distance migration in cervical laminoplasty has not been reported. A 61-year-old woman underwent cervical laminoplasty, three months postoperatively, she experienced left shoulder pain and left upper limb pain, and underwent cervical magnetic resonance imaging, which showed no abnormalities. She gradually developed dizziness, headache, unstable walking, incomplete urinary incontinence, and fluctuating neck lumps. The X-ray showed that the screws of the C7 lateral mass had disappeared and migrated to the sacral canal. The patient underwent cerebrospinal leakage repair and removal of the screws in the spinal canal. Displacement of fixators implanted into the spinal canal after cervical laminoplasty is a rare complication that can cause permanent neurological injury.
Hepatitis B virus infection and intrahepatic cholestasis of pregnancy: a birth cohort study in Lanzhou, China
Authors: Li Wei , Meng Zhaoyan , Da Zhenqiang , Zhao Yue , Wang Fang , Yang Tao , Liu Qing 
Published: February 2024

Abstract
Background: Intrahepatic cholestasis of pregnancy (ICP) has been confirmed to have a clear influence on pregnancy outcome. This study is aimed at investigating the correlation between hepatitis B virus (HBV) infection and ICP, and confirming whether HBV infection may aggravate the adverse fetal or maternal outcomes of ICP.
Methods: A birth cohort study was conducted from 2010–2012 at Gansu Provincial Maternity & Child Care Hospital in Lanzhou, China. A total of 10,536 pregnant women without chronic hepatopathy were enrolled. HBV infection was defined by the presence of hepatitis B virus antigens (HBsAg) positive.
Results: 259 (2.46%) women were diagnosed with ICP and it was observed that maternal HBV infection increased the risk of ICP (OR:1.95, 95%CI:1.17-3.24). Compared to non-ICP with HBV negative women, ICP with HBV positive women were more likely to have postpartum hemorrhage (PPH) (p=0.019), caesarean section(p<0.0001), and preterm birth(p<0.0001). When ICP was combined with HBV infection, after adjusting for influencing factors, the risk of PPH was increased compared with ICP with HBV negative (OR: 6.65, 95%CI: 1.30-33.95), non-ICP with HBV positive (OR: 11.16, 95%CI: 1.83-68.18), or non-ICP with HBV negative (OR: 10.12, 95%CI: 2.72-37.67).
Conclusions: Our study supports the hypothesis that HBV infection increases the risk of ICP. Furthermore, it indicates that ICP combined with HBV infection substantially increases PPH risk.
CircMTDH promotes the development of gastric cancer and the mechanism
Authors: Hu Feng , Zhu Yonggang , Ma Zhanchuan , Zhang Manli , Meng Qingqing , Zhang Xiuna , Liu Guangming , Rao Min 
Published: February 2024

Abstract
Gastric cancer (GC), with high incidence and mortality, is one of the deadliest cancers, significantly impacting human health and imposing a huge socioeconomic burden. This disease is usually found at a later period due to lacking effective early diagnostic methods, leading to poor treatment outcomes and prognosis. Therefore, exploring effective biomarkers is crucial for a definite diagnosis and treatment of this disease. Circular RNA (circRNA) has been found to have significant effects during the generation and progression of GC, presenting a potential to be developed as early diagnostic markers for this disease. This study identified a circular RNA named circMTDH, that with a significantly higher expression in GC patients’ tissues and cells, which is closely related to the tumor size. Further investigation unveiled that circMTDH promotes GC development through circMTDH/miR-1287-5p/paxillin (PXN) axle. Exactly, circMTDH promotes the proliferation, migration, and invasion of gastric cancer cells by modulating the levels of miR-1287-5p and PXN expression. On the other hand, circMTDH expedites the development of tumors in mice by accelerating macrophages to polarize from M0 to M2. These findings indicate that circMTDH holds promise as a diagnostic biomarker, assisting in GC treatment and prognosis assessment.
Surface Defect Detection of Printed Circuit Board With Large Kernel Convolutional Networks
Authors: Wang Yuanyuan , Huang Jialong , DIPU MD SHARID KAYES , Gao Shangbing , Zhang Haiyan , Zhou Liguo , Abdullahi Hauwa Suleiman 
Published: February 2024

Abstract

The defect detection of printed circuit boards (PCBs) is a crucial step in the production process. Defects usually appear in small sizes, thus image data needs to be obtained using high-resolution camera equipment, which leads to the model requirement to process high-resolution images. In addition, there is an imbalance issue in defect categories. In order to have a more efficient and accurate PCB defect detection method in the production process,we propose the Residual Large Convolutional Network (ResLCNet) as the backbone of YOLOv5. This article draws inspiration from the application of Transformers in the field of vision and finds that using large convolution kernels instead of a bunch of traditional 3x3 small convolution kernels is a more powerful standard. In traditional concepts, large convolutions require a lot of computation and consume a lot of resources. However, through efficient convolutional network structure optimization methods, we can make large kernel convolutions more powerful, and at the same time, large kernel networks integrate some advantages of kernel methods and can adaptively learn feature representations of data, thereby shortening the distance between CNN and Transformers. After training and testing on the PCB defect dataset, our method achieved an average mAP value of 95.6% after multiple experiments, which is 1.2% higher than the original YOLOv5. The large kernel network proposed in this article reduces background interference to a certain extent and has high accuracy, providing ideas for using large convolutional kernels as the backbone to improve the accuracy of industrial defect detection in the future.Code & models at https://github.com/hjllovecv/Yolov5-ResCL
Genomic analysis of a spontaneous unifoliate mutant reveals gene candidates associated with compound leaf development in Vigna unguiculata [L] Walp
Authors: Edet Offiong Ukpong , Ubi Benjamin Ewa , Ishii Takayoshi 
Published: February 2024

Abstract

Molecular mechanisms which underpin compound leaf development in some legumes have been reported, but there is no previous study on the molecular genetic control of compound leaf formation in Vigna unguiculata (cowpea), an important dryland legume of African origin. In most studied species with compound leaves, the expression of class 1 KNOTTED-LIKE HOMEOBOX genes in developing leaf primordia sustains morphogenetic activity, thus inhibiting cell differentiation. Other genes, such as, SINGLE LEAFLET1 in Medicago truncatula and Trifoliate in Solanum lycopersicum, are also implicated in regulating compound leaf patterning. To set the pace for an in-depth understanding of the genetics of compound leaf development in cowpea, we used RNA-seq and whole genome shotgun sequence datasets of a spontaneous cowpea unifoliate mutant and its trifoliate wild-type cultivar to conduct comparative reference-based gene expression, de novo genome-wide isoform switch, and genome variant analyses between the two genotypes. Our results suggest that genomic variants upstream of LATE ELONGATED HYPOCOTYL and down-stream of REVEILLE4, BRASSINOSTERIOD INSENSITIVE1 and LATERAL ORGAN BOUNDARIES result in down-regulation of key components of cowpea circadian rhythm central oscillator and brassinosteriod signaling, resulting in unifoliate leaves and brassinosteriod-deficient-like phenotypes. We have stated hypotheses that will guide follow-up studies expected to provide more insights.
Unveiling the Hidden Role of SNRPB2 in HCC: A Promising Target for Therapy
Authors: Guo Jiaxing , Li Lingshu , Wang Haiyan , Gao Zhenqin , Shen Chanjuan , Yan Bokang 
Published: February 2024

Abstract
Background: SNRPB2, a spliceosome component, is well known to participate in the pre-splicing of mRNA and plays a crucial role in the progression of several cancers. However, its precise effect on HCC remains unexplored.
Methods: Bioinformatics analysis was carried out using TCGA, GTEx, GEO, HPA, CPTAC, Kaplan-Meier plotter, RNAactDrug, and R Studio.The level of SNRPB2 expression in HCC was validated via RT-qPCR, western blot, and IHC. Functional experiments, including CCK8, transwell, and colony formation assays, as well as nude mouse xenograft model, were employed for the purpose of in vitro and in vivo validation. IHC, CCK8, colony formation assays, and measurements of GSH, lipid ROS, and ferrous iron were performed to evaluate the impact of SNRPB2 on the ferroptosis of HCC cells. Databases including miRDB, miRWalk, Targetscan, miRabel, CancerMIRNome, and ENCORI, correlation analysis, RT-qPCR, and luciferase reporter assays were employed to identify the ceRNA regulatory axis of SNRPB2. Sorafenib resistant HepG2 cell line was developed to examine the effect of SNRPB2 on sorafenib resistance.
Results: Here, we demonstrate that high level of SNRPB2 is significantly associated with poor outcomes in HCC patients. Additionally, inhibiting SNRPB2 may accelerate ferroptosis, thereby suppressing HCC tumor development. Moreover, SNRPB2 is regulated by the SNHG4/miR-204-5p axis, and increased SNHG4 could reverse the effect of SNRPB2 knockdown. Finally, SNRPB2 deficiency increases the sorafenib sensitivity of HCC cells.
Conclusion: Conclusively, our study uncovers the previously unknown role of SNRPB2 in HCC, reveals the related ceRNA regulatory axis of SNRPB2, and identifies a novel ferroptosis regulating protein, suggesting SNRPB2 appears to be a promising target for HCC therapy.