bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmological observational constraints on the power law f(Q) type modified gravity theory
Authors: Mandal Sanjay , Pradhan Sneha , Sahoo P. K. , Harko Tiberiu 
Published: December 2023

AbstractIn modern cosmology, the curiosity of ultimately understanding the nature of the dark energy controlling the recent acceleration of the Universe motivates us to explore its properties by using some novel approaches. In this work, to explore the properties of dark energy we adopt the modified f(Q) gravity theory, where the non-metricity scalar Q, emerging from Weyl geometry, plays the dynamical role. For the function f(Q) we adopt the functional form $$f(Q)=Q+ 6\gamma \,H_0^2(Q/Q_0)^n$$

f

(
Q
)

=
Q
+
6
γ

H
0
2

(
Q
/

Q
0

)

n

, where $$n,\, \gamma ,\, H_0$$

n
,

γ
,

H
0

and $$Q_0$$

Q
0

are constants. Then, we test our constructed model against the various observational datasets, such as the Hubble, and the Pantheon+SHOES samples, and their combined sample, through the Markov Chain Monte Carlo (MCMC) statistical analysis. We also employ the parameter estimation technique to constrain the free parameters of the model. In addition, we use the constrained values of the model parameters to explore a few implications of the cosmological model. A detailed comparison of the predictions of our model with the $$\Lambda $$
Λ
CDM model is also performed. In particular, we discuss in detail some cosmographic parameters, like the deceleration, the jerk, and the snap parameters, as well as the behavior of the dark energy and matter energy densities to see the evolution of various energy/matter profiles. The Om diagnostics is also presented to test the dark energy nature of our model, as compared to the standard $$\Lambda $$
Λ
CDM paradigm. Our findings show that the considered version of the non-metric f(Q) type modified gravity theory, despite some differences with respect to the $$\Lambda $$
Λ
CDM paradigm, can still explain the current observational results on the cosmological parameters, and provide a convincing and consistent account for the accelerating expansion of the Universe.
Convective mixing in porous media: a review of Darcy, pore-scale and Hele-Shaw studies
Authors: De Paoli Marco 
Published: December 2023

Abstract
Convection-driven porous media flows are common in industrial processes and in nature. The multiscale and multiphase character of these systems and the inherent nonlinear flow dynamics make convection in porous media a complex phenomenon. As a result, a combination of different complementary approaches, namely theory, simulations and experiments, have been deployed to elucidate the intricate physics of convection in porous media. In this work, we review recent findings on mixing in fluid-saturated porous media convection. We focus on the dissolution of a heavy fluid layer into a lighter one, and we consider different flow configurations. We present Darcy, pore-scale and Hele-Shaw investigations inspired by geophysical processes. While the results obtained for Darcy flows match the dissolution behaviour predicted theoretically, Hele-Shaw and pore-scale investigations reveal a different and tangled scenario in which finite-size effects play a key role. Finally, we present recent numerical and experimental developments and we highlight possible future research directions. The findings reviewed in this work will be crucial to make reliable predictions about the long-term behaviour of dissolution and mixing in engineering and natural processes, which are required to tackle societal challenges such as climate change mitigation and energy transition.

Graphic abstract
ON GENERAL LOCAL FRACTIONAL INTEGRAL INEQUALITIES FOR GENERALIZED H-PREINVEX FUNCTIONS ON YANG’S FRACTAL SETS
Authors: ZHANG YONG , SUN WENBING 
Published: December 2023

In this paper, based on Yang’s fractal theory, the Hermite–Hadamard’s inequalities for generalized [Formula: see text]-preinvex function are proved. Then, using the local fractional integral identity proposed by Sun [Some local fractional integral inequalities for generalized preinvex functions and applications to numerical quadrature, Fractals 27(5) (2019) 1950071] as auxiliary function, some parameterized local fractional integral inequalities for generalized [Formula: see text]-preinvex functions are established. For the special cases of the parameters, some generalized Simpson-type, midpoint-type and trapezoidal inequalities are established. Finally, some applications of these inequalities in numerical integration are proposed.
Efficacy of the Enteroadsorbent Silicol®gel in Adults with Irritable Bowel Syndrome Subtypes IBS-D or Mixed: Observational Open-Label Study
Authors: Crawford Gordon , Taylor Rory , Young David , Hatton Chris G. 
Published: December 2023

Background. Irritable bowel syndrome (IBS) is a common chronic gut-brain interaction disorder with limited effective treatment options. Intestinal adsorbents have a high adsorption capacity for gut irritants and may provide nonpharmacological alternatives. Objectives. This post marketing study is aimed at providing up-to-date evidence to support the safety and efficacy in normal use of an established medical device for IBS treatment. Methods. In this open-label, observational study, adults with IBS with predominant diarrhoea (IBS-D) or IBS with mixed bowel habits (IBS-M), according to Rome IV criteria, received 4 weeks of treatment with the enteroadsorbent Silicol®gel, a CE-certified, licenced, medical device containing colloidal silicic acid. Eligible participants were assessed at baseline (visit 1; in-clinic) and after 1 (visit 2; telephone), 2 (visit 3; telephone), and 4 (visit 4; in-clinic) weeks of treatment. The primary endpoint was the proportion of participants with an overall reduction in the IBS severity scoring system

IBS

SSS

>
50

, representing clinically meaningful improvement. Key secondary endpoints were a reduction in common IBS symptoms and improved quality of life (QoL). Results. Among the 67 treated participants (IBS-D: 37; IBS-M: 30), 65 completed the study. At visit 4, 83.6% (56/67) of participants achieved a reduction in IBS

SSS
>
50

. The mean (standard deviation [SD]) IBS SSS was 323.4 (55.7) at visit 1 and 160.3 (90.3) at visit 4 (overall change: -163.1 (101.7); 95% confidence interval [CI] 138.3, 187.9,

p
<
0.001

). Compared with visit 1, significant reductions in the severity of all key IBS symptoms and overall improvement in QoL were observed at visit 4 (

p
<
0.001

), with improvements observed from visits 1 and 2. Conclusions. In this open-label study of participants with IBS-D and IBS-M, Silicol®gel provided clinically significant improvement in IBS symptoms, demonstrating that enteroadsorbents may be clinically beneficial in this population.
Changes in Serum Concentrations of Bone Turnover Markers in Healthy Pregnant Women
Authors: Zhang Yiduo , Li Ruiying , Zhang Jing , Zhou Wenjie , Yu Fan 
Published: December 2023

Background. Changes in bone metabolism during pregnancy have not received sufficient attention because of the lack of effective screening tools. Bone turnover markers (BTMs) could reflect the changes of bone metabolism. Currently, reference intervals for bone metabolism during normal pregnancy are inconclusive. This study aimed to determine reference intervals for BTMs in pregnant women taking prenatal care and to facilitate clinical research on diseases affecting bone metabolism during pregnancy. Methods. We surveyed 120 low-risk pregnant women attending routine antenatal care from January 2020 to March 2020. The serum levels of procollagen type I N-propeptide (PINP), N-terminal osteocalcin (N-MID), and C-terminal telopeptide of type I collagen (β-CTX) were measured in the first trimester (<13 weeks), second trimester (14–27 weeks), and third trimester (>28 weeks). Reference intervals for BTMs during pregnancy were analyzed. The Kruskal–Wallis test and paired t-test are used to analyze differences between groups. Spearman correlation coefficients expressed the measure of linear association. Results. The bone resorption marker β-CTX in third trimester increases compared to the first trimester and the second trimester (

P

< 0.001,

P

< 0.001). The bone formation markers PINP and N-MID were decreased from the first trimester to the second trimester (

P

= 0.01,

P

< 0.001) and then raised from the second trimester to the third trimester (

P

< 0.001,

P

< 0.001). Two indices of bone turnover rate, β-CTX/PINP and β-CTX/N-MID, were increased from the first trimester to the second trimester (

P

< 0.001,

P

< 0.001) and then decreased from the second trimester to the third trimester (

P

= 0.02,

P

< 0.001). Conclusion. This study established reference intervals for BTMs in pregnant women and observed the changes in BTMs during the different trimesters of pregnancy. The present findings can help in clinical monitoring of the effects of pregnancy diseases on the bone metabolism of pregnant women.
Cost-Effectiveness of Bariatric Surgery in Patients Living with Obesity and Type 2 Diabetes
Authors: Kovács Gábor , Mohos Elemér , Kis János Tibor , Tabák Ádám , Gerendy Péter , Pettkó Judit , Nagy Dávid , Győrbíró Dávid , Kaló Zoltán 
Published: December 2023

Aims. The favourable effects of bariatric surgeries on body weight reduction and glucose control have been demonstrated in several studies. Additionally, the cost-effectiveness of bariatric surgeries has been confirmed in several analyses. The aim of the current analysis was to demonstrate the cost-effectiveness of bariatric surgeries in obese patients with type 2 diabetes in Hungary compared to conventional diabetes treatments based on economic modelling of published clinical trial results. Materials and Methods. Patients entered the simulation model at the age of 45 with

b
o
d
y

m
a
s
s

i
n
d
e
x

B
M
I

≥
30

kg/m2 and type 2 diabetes. The model was performed from the public payer’s perspective, comparing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) procedures to conventional care of diabetes. The results were provided separately for three BMI categories. Results. The base-case analysis demonstrated that both surgery types were dominant; i.e., they saved 17 064 to 24 384 Euro public payer expenditures and resulted in improved health outcomes (1.36 to 1.50 quality-adjusted life years gain (QALY)) in the three BMI categories. Bariatric surgeries extended the life expectancy and the disease-free survival times of all the investigated diabetes complications. All the scenario analyses confirmed the robustness of the base-case analysis, such that bariatric surgeries remained dominant compared to conventional diabetes treatments. Conclusion. The results of this cost-effectiveness analysis highlight the importance of bariatric surgeries as alternatives to conventional diabetes treatments in the obese population. Therefore, it is strongly recommended that a wider population has access to these surgeries in Hungary.
Palazestrant (OP-1250), A Complete Estrogen Receptor Antagonist, Inhibits Wild-type and Mutant ER-positive Breast Cancer Models as Monotherapy and in Combination
Authors: Parisian Alison D. , Barratt Susanna A. , Hodges-Gallagher Leslie , Ortega Fabian E. , Peña Guadalupe , Sapugay Judevin , Robello Brandon , Sun Richard , Kulp David , Palanisamy Gopinath S. , Myles David C. , Kushner Peter J. , Harmon Cyrus L. 
Published: December 2023

Abstract
The estrogen receptor (ER) is a well-established target for the treatment of breast cancer, with the majority of patients presenting as ER-positive (ER+). Endocrine therapy is a mainstay of breast cancer treatment but the development of resistance mutations in response to aromatase inhibitors, poor pharmacokinetic properties of fulvestrant, agonist activity of tamoxifen, and limited benefit for elacestrant leave unmet needs for patients with or without resistance mutations in ESR1, the gene that encodes the ER protein. Here we describe palazestrant (OP-1250), a novel, orally bioavailable complete ER antagonist and selective ER degrader. OP-1250, like fulvestrant, has no agonist activity on the ER and completely blocks estrogen-induced transcriptional activity. In addition, OP-1250 demonstrates favorable biochemical binding affinity, ER degradation, and antiproliferative activity in ER+ breast cancer models that is comparable or superior to other agents of interest. OP-1250 has superior pharmacokinetic properties relative to fulvestrant, including oral bioavailability and brain penetrance, as well as superior performance in wild-type and ESR1-mutant breast cancer xenograft studies. OP-1250 combines well with cyclin-dependent kinase 4 and 6 inhibitors in xenograft studies of ER+ breast cancer models and effectively shrinks intracranially implanted tumors, resulting in prolonged animal survival. With demonstrated preclinical efficacy exceeding fulvestrant in wild-type models, elacestrant in ESR1-mutant models, and tamoxifen in intracranial xenografts, OP-1250 has the potential to benefit patients with ER+ breast cancer.
Movement behaviour of the common frog (Rana temporaria) in an anthropized mountain landscape: integrated step selection analysis of GPS tracking data
Authors: Boncourt Etienne , Reineking Björn , Chambonnet Gabriel , Gaucherand Stéphanie 
Published: December 2023

Abstract
Movement is a key aspect of amphibian ecology as the life cycle of many species involves seasonal dispersal and migration. However, there is still a lack of knowledge about how amphibians move across landscapes in relation to landscape structure and resource availability. Modern lightweight GPS loggers and associated statistical tools offer new perspectives to fill this gap. We tracked the movements of 20 adult European common frogs (Rana temporaria) in a human-transformed mountain landscape during summer using GPS tags programmed with a constant 4-hour time interval between fixes. Using integrated step-selection analysis, we demonstrate firstly that frogs strongly selected aquatic habitats over open grassland. Second, ski runs have a negative effect on frogs, indicated by longer movement steps. Weather (air temperature and rain) had no effect on frog movements. These results constitute a promising first step towards studying anuran movement in relation to landscape structure at fine spatial and temporal scales.
Coping with Food Crises
Authors: Farina Felice 
Published: December 2023

Abstract
In response to three major postwar food crises (1945–1946, 1972–1973 and 2007–2008), Japan developed a distinctive approach to food security. The largest food crisis in Japan’s modern history occurred after the defeat in 1945 as a result of the loss of former colonies, adverse weather, and import limitations imposed by the Allies. In 1973, the United States imposed a soybean embargo, leaving Japan with uncertain supplies. More recently, the 2007–2008 world food prices crisis brought new concerns about Japan’s overreliance on foreign markets. As a result of the cumulative effects of these crises, Japan developed what we define a ‘preventive approach to food security’, whereby it seeks to mitigate the negative effects of any potential future food emergency by promoting self-sufficiency and ensuring a steady supply of imports. In this article we will analyse and clarify the central role of the three postwar food crises in shaping this approach.
A Newly Identified Letter of Valentinus on Jesus’s Digestive System: Ps.-Basil of Caesarea’s ep. 366
Authors: Porter Nathan E. 
Published: December 2023

Abstract
A passage from Ps.-Basil of Caesarea’s ep. 366 contains verbatim parallels with a quotation of Valentinus given in Clement of Alexandria, Strom. 3.7.59.3. These parallels have rarely been recognized by scholars. Völker and Markschies have argued that Ps.-Basil was excerpting from Clement, but this paper argues that Ps.-Basil was independent of Clement and was likely Clement’s source. Overlooked evidence includes (i) the coherence of the parallel passages in the context of ep. 366 and their relative incoherence in the context of Strom. 3.7.59.3; (ii) Valentinian theology that is found throughout ep. 366, including the notions of spiritual bodies and Charis as God’s protological consort; (iii) grammatical errors in Clement that are not present in Ps.-Basil; and (iv) further textual evidence suggesting that ep. 366 has the original version of the passage. A plausible explanation of the evidence, this paper will argue, is that ep. 366 comes from the pen of Valentinus himself.
‘Being an Alevi Woman Means Enlightenment and Freedom’: Insights into Gender Equality through Cemevi and Dergah Case Studies in Istanbul
Authors: de Obaldía Vanessa R. 
Published: December 2023

Abstract
The main aim of this study is to demonstrate the principle of gender equality in relation to its spatial and practical implementation in Alevi places of worship (cemevi and dergah) and in participatory roles within Alevi institutions from two perspectives. Firstly, in terms of women’s empowerment and participation at the administrative level through case studies of Hazreti Ali Cemevi in Sultangazi and Karaağaç Bektaşi Dergah in Sütlüce, both of which are presided over by women presidents. Secondly, in relation to spatial access and participation in rituals and religious festivities at the small Adalar Cemevi located on the multi-faith Burgaz Island analysed in comparative perspective with the extensive Kartal Cemevi situated in the Muslim majority district of Kartal. This study also briefly addresses the erosion of Alevi gender principles within the urban setting and its attributing factors.
Intersection of the Rights to Freedom of Belief and Gender Equality in Turkey
Authors: Yılmaz Zehra , Arslan Hilal 
Published: December 2023

Abstract
Despite the efforts of the women’s movement in Turkey, gender equality as a norm has been abandoned in state policies due to the rise of neoliberal authoritarianism. Our study aims to take a snapshot of religious services access and gender equality while stressing the parallel norms by focusing on justice, equality and the prohibition of discrimination. Further, since ensuring freedom of religion or belief and gender equality is the duty of the state, our research exposes the legal and institutional framework regulating the intersection of these two fundamental human rights areas and Turkey’s related policies and practices. In doing so, the study delves into the state’s adherence to international human rights treaties and elaborates on women’s positioning in the organization of religious services, as well as shedding light on human rights protections and observed violations of those rights within the spheres of family law and religious education.
Constitutional Limits of Islamic Law: God in the Preamble to the Indonesian Constitution
Authors: Rofii Ahmad 
Published: December 2023

Abstract
The references to God in the preamble to the Indonesian Constitution raise a fundamental question, “do these references mean that the Constitution should be religious?” This paper aims to propose a new interpretation to the references to God in the preamble. Particularly, it suggests reinterpretation of the trajectory of the phrase “belief in One and Only God” in the making of the 1945 Constitution and during the amendment process, and of its legal significance. This article will also examine the implication of those references for the legitimacy of the state implementation of Islamic law. By analyzing the Constitutional Court’s decisions in the Religious Court Jurisdiction case, this article further investigates the implication of the constitutional interpretation of this phrase for the constitutionality of Islamic law. It argues that the preamble which is secular in nature provides the paradigm for enabling and limiting the institutionalization of religion, including Islamic law.
The Imagination of Japan
Authors: Ragazzini Jessica 
Published: December 2023

Abstract
The arrival of the 21st century ushered in an era when fears and hopes crystallized around Japan, then perceived in the West as a country of new technologies. It was also seen as the nation of new fashion designers and in the 1990s Western media attributed a distinctly ‘Japanese character’ to the collections of Japanese fashion designers who stood out internationally. This article explores the encounter between the stereotypes of a Japan imagined by the West and the real clothing collections offered by brands such as Comme des Garçons, who exercised a major influence, in particular on Alexander McQueen and Iris van Herpen. In addition, this article aims to draw the attention of academic research to the unprecedented crossovers that fashion allows.
The Ho-o-den at the World’s Columbian Exposition
Authors: Whitmore Janet 
Published: December 2023

Abstract
The Japanese pavilion at the 1893 World’s Columbian Exposition was much admired by visitors. Unlike most of the fair buildings, however, the Ho-o-den remained in situ on the Wooded Island long after the exposition was over, thus providing an architectural reference for anyone interested in Japanese design. This article details the design, construction and initial reception of the Ho-o-den at the fair. A second article will explore the enduring influence of the building on American design.
Climate Litigation in Argentina: A Critical and Prospective Analysis
Authors: Medici-Colombo Gastón , Berros María Valeria 
Published: December 2023

Abstract
This article analyses the climate litigation scenario in Argentina. Based on the Sabin Center Database, we conducted an in-depth study of all the proceeding documents of the identified cases. We found that, in Argentina, a significant number of climate cases exists compared to other jurisdictions in the region and in the Global South as a whole. These cases show civil society actors suing public and corporate actors due to the deployment of ‘climate-disruptive’ projects or the failed protection of climate-relevant ecosystems. Plaintiffs use a variety of judicial avenues and grounds from different regulatory levels. That said, the case law study leads us to conclude that climate litigation is still incipient in Argentina. Climate change is a very novel legal issue for Argentinean litigants and courts, with lawsuits only developing actual climate argumentation very recently and with not even one judgment, let alone a landmark decision, addressing climate concerns. That is a notable difference from other jurisdictions in the region. Furthermore, we anticipate that climate litigation will continue to grow in Argentina, given weak political opportunities for climate action and stronger legal opportunities provided by broad judicial avenues, a multiplicity of grounds that can be used in climate arguments, and innovative environmental legal approaches developed by the Supreme Court.