bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative flexible thermal storage textile using nanocomposite shape-stabilized phase change materials
Authors: Zeighampour Farideh , Khoddami Akbar , Dolez Patricia I. 
Published: December 2023

AbstractA novel flexible thermal storage system based on organic phase change materials (PCMs) deposited on a non-woven polyester (PET) substrate is described in this article. Thermally regulating effects were created via encapsulation of polyethylene glycol (PEG) in carbon nanofibers (CNFs) to manufacture a shape-stable phase change material (SSPCM). Improvement in the thermal conductivity (TC) of the system was obtained by incorporating reduced graphite oxide nanoparticles (rGONP) into the CNFs. A new method was applied to load and secure the manufactured SSPCMs on the fibrous substrate so that an acceptable level of flexibility was preserved (change in bending length less than 30%). The sample performance was evaluated by measuring its thermal properties. The physical properties, wash fastness, abrasion resistance, morphology, and PCM leakage of the samples were also assessed. The results point to a good thermal storage ability of the samples with characteristic phase change temperature ranges of 30.1–31.4 °C and 19.2–24.3 °C for melting and freezing, respectively, and a latent heat of 8.9–22.9 J g−1 for meting and 11.2–21.4 J g−1 for freezing. The use of the CNF-rGONP for PEG enhanced the TC of the system by 454%, thus providing a rapid thermal response, and efficiently prevented the leakage of PEG. Finally, the loading and fixation method on the non-woven substrate allowed an acceptable level of durability with less than 4% of weight loss during washing and abrasion tests. This system provides a promising solution for rapid response, flexible thermal storage wearables.
Canakinumab Versus Placebo in Combination With First-Line Pembrolizumab Plus Chemotherapy for Advanced Non–Small-Cell Lung Cancer: Results From the CANOPY-1 Trial
Authors: Tan Daniel S.W. , Felip Enriqueta , de Castro Gilberto , Solomon Benjamin J. , Greystoke Alastair , Cho Byoung Chul , Cobo Manuel , Kim Tae Min , Ganguly Sandip , Carcereny Enric , Paz-Ares Luis , Bennouna Jaafar , Garassino Marina Chiara , Schenker Michael , Kim Sang-We , Brase Jan C. , Bury-Maynard Denise , Passos Vanessa Q. , Deudon Stéphanie , Dharan Bharani , Song Yuanbo , Caparica Rafael , Johnson Bruce E. 
Published: December 2023

PURPOSE The addition of checkpoint inhibitors to first-line treatment has prolonged survival of patients with non–small-cell lung cancer (NSCLC), but prognosis remains poor, with new treatment options needed. Canakinumab, a human, monoclonal anti–interleukin (IL)-1β antibody, has potential to enhance the activity of PD-L1 inhibitors and chemotherapy (CT) by inhibiting protumor inflammation. METHODS CANOPY-1 was a phase III, randomized, double-blind study comparing canakinumab (200 mg subcutaneously once every 3 weeks) versus placebo, both combined with pembrolizumab (200 mg intravenously once every 3 weeks) and platinum-based doublet CT, as first-line treatment for advanced/metastatic NSCLC without EGFR or ALK mutations. The primary end points were progression-free survival (PFS) and overall survival (OS). The secondary endpoints included overall response rate, safety, and patient-reported outcomes. RESULTS Overall, 643 patients were randomly assigned to canakinumab (n = 320) or placebo (n = 323). With a median study follow-up of 6.5 months, the median PFS was 6.8 months with canakinumab versus 6.8 months with placebo (hazard ratio [HR], 0.85; 95% CI, 0.67 to 1.09; P = .102). With a median study follow-up of 21.2 months, the median OS was 20.8 months with canakinumab versus 20.2 months with placebo (HR, 0.87; 95% CI, 0.70 to 1.10; P = .123). No unexpected safety signals were observed for canakinumab combination. Infection rates were comparable between treatment and control arms. A higher frequency of neutropenia and ALT increase (grade ≤2) were reported in the treatment arm. Higher baseline C-reactive protein and IL-6 levels were associated with shorter PFS and OS. Patients treated with canakinumab had clinically meaningful delays in deterioration of lung cancer symptoms, including chest pain and coughing per LC13 and dyspnea per LC13 and C30. CONCLUSION The addition of canakinumab to first-line pembrolizumab and CT did not prolong PFS or OS in patients with NSCLC.
What Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators
Authors: Mulders Merijn C F , de Herder Wouter W , Hofland Johannes 
Published: December 2023

Abstract
Carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal mediators considered to play a causative role in CS. Overall, evidence for the putative mediators of CS was scarce and often of poor quality. Based on the available literature, data are only sufficient to agree on the role of serotonin as a mediator of CS-associated diarrhea and fibrosis. A direct role for tachykinins and an indirect role of catecholamines in the pathogenesis of CS is suggested by several studies. Currently, there is insufficient evidence to link histamine, bradykinin, kallikrein, prostaglandins, or motilin to CS. To summarize, available literature only sufficiently appoints serotonin and suggests a role for tachykinins and catecholamines as mediators of CS, with insufficient evidence for other putative mediators. Descriptions of CS should be revised to focus on these proven hormonal associations to be more accurate, and further research is needed into other potential mediators.
Protecting the Musulman Children
Authors: Kind Kevin 
Published: December 2023

Abstract
This article draws on archival materials from late Qing Turpan Prefecture to explore Qing colonialism within the context of mass vaccination efforts in Xinjiang from 1880 to 1911. Following the reconquest of the region in 1877, Xiang Army leaders established official vaccination bureaus across Xinjiang—a colonial administration that encompassed all of East Turkestan—to combat smallpox outbreaks within Musulman (Uyghur) communities and the Qing army garrison. The vaccination bureau in Turpan, although led by Han vaccinators from Inner China, depended heavily on the labor of Musulman graduates from the region's assimilationist Confucian schools. The Turpan Vaccination Bureau reinforced the Xiang Army's broader project of colonial assimilation by training Musulman apprentices in various Chinese medical texts and using them to disseminate these ideas across the prefecture through the medium of vaccination. However, Turpan's Musulmans possessed their own sophisticated body of knowledge regarding epidemics and healing and routinely resisted the imposition of normative Qing/Chinese medical behavior.
A MEDIUM-TERM REVIEW OF THE OUTCOMES OF TALAR OSTEOCHONDRAL LESIONS TREATED WITH MATRIX-ASSOCIATED STEM CELL TRANSPLANTATION
Authors: Faustino A , Murphy E , Curran M , Kearns S 
Published: December 2023

IntroductionOsteochondral lesions (OCLs) of the talus are a challenging and increasingly recognized problem in chronic ankle pain. Many novel techniques exist to attempt to treat this challenging entity. Difficulties associated with treating OCLs include lesion location, size, chronicity, and problems associated with potential graft harvest sites. Matrix associated stem cell transplantation (MAST) is one such treatment described for larger lesions >15mm2 or failed alternative therapies. This cohort study describes a medium-term review of the outcomes of talar lesions treated with MAST.MethodsA review of all patients treated with MAST by a single surgeon was conducted. Preoperative radiographs, MRIs and FAOS outcome questionnaire scores were conducted. Intraoperative classification was undertaken to correlate with imaging. Postoperative outcomes included FAOS scores, return to sport, revision surgery/failure of treatment and progression to arthritis/fusion surgery.Results58 MAST procedures in 57 patients were identified in this cohort. The mean follow up was 5 years. There were 20 females and37males, with a mean age of 37 years (SD 9.1). 22 patients had lateral OCLS were and 35 patients had medial OCLs. Of this cohort 32patients had previous surgery and 25 had this procedure as a primary event. 15 patients had one failed previous surgery, 9 patients had two, four patients had three previous surgeries and three patients had four previous surgeries. 12 patients had corrective or realignment procedures at the time of surgery. In terms of complications 3 patients of this cohort went on to have an ankle fusion and two of these had medial malleolar metal work taken out prior to this, 5 patients had additional procedures for arthrofibrotic debridements, 1 patient had a repeat MAST procedure, 1 additional patients had removal of medial malleolar osteotomy screws for pain at the osteotomy site, there were 2 wound complications one related to the ankle and one related to pain at the iliac crest donor site.ConclusionMAST has demonstrated positive results in lesions which prove challenging to treat, even in a “ failed microfracture” cohort.RCT still lacking in field of orthobiologics for MAST. Longer term follow up required to evaluate durability.
QUADRICEPS AUTOGRAFT FOR MPFL RECONSTRUCTION IN PAEDIATRIC PATELLOFEMORAL INSTABILITY: EXPERIENCE FROM A TERTIARY CHILDREN'S KNEE UNIT
Authors: Basheer S , Ali F , Nicolaou N 
Published: December 2023

IntroductionPatellofemoral instability is one of the most common presentations to a children's orthopaedic clinic. Recurrent patellar dislocations and instability episodes are painful, disabling and increase the risk of irreversible chondral damage. The medial patellofemoral ligament is the primary static stabiliser to prevent lateral dislocation of the patella and is almost always torn or attenuated in these cases. Reconstruction of this ligament is commonly performed using autologous hamstring tendon however there has been some interest recently in use of quadriceps tendon as a graft. Children with patellar instability also present unique challenges due to the small size of the patella and the presence of open growth plates which may require adaptations to the common techniques.MethodsPatients undergoing medial patellofemoral ligament reconstruction using quadriceps tendon autograft were identified using electronic theatre records. Prospectively collected clinical records and imaging findings were reviewed and underlying pathology, additional procedures at time of MPFL reconstruction, current function and need for further revision surgery determined.ResultsBetween January 2019 and August 2023, 50 MPFL reconstructions were performed in 37 children using partial thickness quadriceps autograft. Patient age at time of surgery ranged from 5 to 17 years (median age 13 years). The technique was utilised for a variety of indications including recurrent traumatic and habitual patellofemoral instability, fixed dislocations, and revision MPFL reconstruction.ConclusionPartial thickness quadriceps tendon autograft can be used safely to primarily reconstruct the medial patellofemoral ligament in paediatric population, including those children with open growth plates. It also has utility in revision cases following previous failed hamstring MPFL reconstruction. We have noted that the younger the child, the more distal to the physis lies the femoral point of isometricity, rendering this a safe and reproducible treatment in this age group. Use of this technique has increased in our unit as we have observed that patients seem to be satisfied with their clinical and functional outcomes with a low incidence of short- and medium-term complications.
LONG-TERM CLINICAL OUTCOMES AFTER SINGLE- VERSUS DOUBLE-BUNDLE ACL RECONSTRUCTION: A MATCHED-PAIR ANALYSIS FROM THE SANTI STUDY GROUP
Authors: Hems A , Hopper G , An JS , Lahsika M , Giurazza G , Vieira T Dutra , Sonnery-Cottet B 
Published: December 2023

IntroductionIt has been contentious whether an anatomic double-bundle technique for anterior cruciate ligament reconstruction (ACLR)is superior to that of a single-bundle technique. It has been hypothesized in the literature that the double-bundle technique could provide function closer to that of the anatomical knee joint. The purpose of this study was to compare the long-term clinical outcomes after single-bundle ACLR versus double-bundle ACLR. We hypothesized that the double-bundle technique would not be superior to the single-bundle technique.MethodsA retrospective, non-randomized, matched-paired comparative study was performed. Patients undergoing primary anterior cruciate ligament reconstruction, using either a double-bundle or single-bundle technique, between 2003 and 2008 were included and matched 1:1. Matching included age, sex, BMI, time from injury to surgery, side of injury and type of sport. Patients who underwent revision procedures, multiligament reconstruction or other ACLR techniques were excluded. Patients were subsequently followed up, noting occurrence of graft rupture and any other complications.ResultsA total of 1377 ACLRs were performed during the study period. Seven hundred and fifty-six patients were excluded, leaving 396patients to be included in the matching (198 matched pairs). Mean follow-up time was 176.7 +/− 7.7 months (range, 166–211 months). Overall, 40 patients (10.1%) suffered from a graft rupture which consisted of 22 patients (11.1%) in the single-bundle group and 18patients (9.1%) in the double-bundle group. A multivariate analysis was performed using the Cox model and demonstrated that graft failure had no significant association with the surgical technique (hazard ratio (HR), 0.857(0.457;1.609), p=0.6313). (Figure 1) Five patients (2.5%) in the single-bundle group and 7 patients (3.5%) in the double-bundle group underwent secondary surgery for cyclops syndrome(p=0.5637). Three patients (1.5%) in the single-bundle group and 2 patients (1.0%) in the double-bundle group underwent arthrolysis(p=0.6547). Seven patients (3.5%) in the single-bundle group underwent secondary meniscectomy compared to 6 patients (3.0%) in the double-bundle group (p=0.7630).ConclusionDouble-bundle ACLR is not superior to single-bundle ACLR at long-term follow up. Therefore, orthopaedic surgeons do not need to use a double-bundle technique when performing ACL reconstruction.For any figures or tables, please contact authors directly.
Del gusto al disgusto
Authors: De Haro Licer Josep 
Published: December 2023

El sentido del gusto es un sentido, parcialmente olvidado, por la poca conciencia que tenemos de él, a pesar de ser utilizado con gran fruición cada día. El conocimiento actual (que no la pedagogía del momento) nos habla de la existencia de 4 gustos (dulce, salado, ácido y amargo) ampliados a 5 (umami), ubicados en la lengua y ampliada su extensión al paladar blando, faringe, epiglotis y laringe. Dentro de este marco se describen los más o menos 5 000 botones gustativos que contienen los distintos tipos de papilas gustativas, encargadas de activar los gustos descritos. Incluso se exponen los receptores de membrana que gestionan los gustos. Sin embargo, poco se habla de los otros gustos que poseemos (Kokumi, picante, frío, hormigueo, astringente, metálico, mineral) y de los que se está investigando (grasa y almidón).
Endoparásitos de moscas negras (Diptera: Simuliidae) del oeste de España y sus posibles implicaciones en salud pública y veterinaria
Authors: López-Peña David , Falcó-Garí José Vicente , Portillo-Rubio Manolo , Fernández-Soto Pedro 
Published: December 2023

La familia Simuliidae, perteneciente al orden Díptera, se encuentra representada actualmente por 2 415 especies a nivel mundial, entre las cuales destacan aquellas con hábitos hematófagos debido a su potencial como vectores de agentes causantes de enfermedad, tanto en animales como en personas. De igual modo, estos dípteros ortorrafos pueden sufrir daños ocasionados por el parasitismo ejercido por diferentes especies de nematodos de la familia Mermithidae. El mencionado tipo de endoparasitismo desencadena mortandad, principalmente en el estado larvario de los simúlidos afectados.
Sobre la circulación transatlántica de un fado portugués
Authors: Dalbosco María Dulce 
Published: December 2023

La finalidad del presente artículo es reflexionar sobre la circulación, la recepción y los usos de la canción popular como instancias productoras de sentido, susceptibles de transformar su contenido discursivo y, en último término, multiplicar el objeto canción. Para ello, nos proponemos reconstruir algunos trazos de la biografía personalizada y social de la canción «Uma casa portuguesa», desde su composición en Mozambique en los años 50, su posterior apropiación por un Portugal salazarista, hasta su desembarco en Argentina. En particular nos detendremos en las disidencias en la decodificación discursiva de la canción: si durante años muchos fadistas portugueses se negaron a cantar «Uma casa portuguesa» por considerarla un símbolo de los mecanismos de adormecimiento y promoción del statu quo empleados por el Estado Novo, para los descendientes de la inmigración portuguesa en la Argentina dicha canción adquirió otras connotaciones al erigirse como emblema identitario.
Partimos de la concepción de las canciones populares como productos intermediales cuya complejidad semiótica converge de la interacción entre letra, música, interpretación, circulación, mediación, edición y narrativa visual.
Innovación y desarrollo en la región de La Plata. El caso del sector espacial durante la posconvertibilidad
Authors: Langard Federico , Del Negro Leonel , Arturi Diego 
Published: December 2023

El presente trabajo analiza desde una escala regional la cadena de valor que estructura el sector espacial argentino y la articulación entre las empresas privadas y los centros y laboratorios públicos de innovación y desarrollo durante la posconvertibilidad (2003-2021). El recorte territorial se centra en la región de La Plata y localidades cercanas.
Asimismo, se trabaja en este artículo la idea de bienes complejos, esta noción remite a productos “basados en proyectos”, de un alto costo unitario y “hechos a medida”. Estos bienes se caracterizan por contener en sus partes bienes de capital, motorizando de esta manera el entramado de industrias de alto valor agregado.
En la región estudiada, la Facultad de Ingeniería de la UNLP y otros centros de investigación (UNLP-CONICET-CIC) han desarrollado actividades de fundamental importancia para el programa espacial argentino, sumándose en la cercana localidad de Pipinas, el Centro Espacial de Punta Indio (VENG-CONAE).
agendas de la economía social y solidaria y la economía popular. Entre los proyectos populares y las políticas estatales
Authors: Deux Marzi Maria Victoria , Rach Diego , Vignolo Carlos 
Published: December 2023

Este trabajo se propone contribuir al campo de estudios de la economía popular, social y solidaria, apostando a una perspectiva epistemológica y política que reúne experiencias heterogéneas. Asume una mirada común que integra diferentes colectivos laborales e identidades, con el objetivo de abonar a su unidad estratégica e indagar acerca de su potencialidad. En base a fuentes secundarias, reconstruye y analiza las demandas y reivindicaciones de dos organizaciones representativas del trabajo asociado: la Confederación Nacional de Cooperativas de Trabajo (CNCT) y la Unión de Trabajadores de la Economía Popular (UTEP).
Se pregunta por las convergencias y divergencias en las agendas de ambas organizaciones y por la capacidad de estos actores para articular demandas urgentes con la construcción de un proyecto popular “desde abajo” que guíe su lucha y a la vez tensione y permee las intervenciones estatales.
problema de los datos para un análisis urbano-regional a escala nacional en Argentina
Authors: Schweitzer Mariana , Petrocelli Santiago Pablo 
Published: December 2023

La desigualdad socioterritorial en Argentina se expresa en un ciclo que tiende a retroalimentarse con la re-concentración de capital, personas, actividades, infraestructuras y servicios en el área central del país, mientras que vastas zonas quedan rezagadas por la selectividad espacial de los procesos de acumulación. En este marco cobra especial relevancia el rol del estado y la recuperación de la escala nacional en la movilización de políticas públicas orientadas a la mitigación de la desigualdad socioterritorial, para lo que se requiere un análisis urbano-regional multidimensional y multiescalar desde donde formularlas.
A tales efectos se problematiza la construcción de los datos, sus potencialidades, alcances y límites explicativos, se identifican deficiencias de información y se proponen abordajes que contemplan el replanteo de las unidades de análisis, la complejidad y diversidad funcional de los aglomerados, los flujos entre ellos, la dinámica demográfica, las condiciones de vida, así como aspectos relativos al mercado de trabajo.
La participación política de las mujeres. Avances y desafíos político-partidarios en la Provincia de Santa Fe
Authors: Hynes Erica Rut 
Published: December 2023

Partiendo de reconocer el largo camino recorrido por las mujeres a nivel internacional y nacional, se busca reflexionar respecto de la ausencia de mujeres en lugares de decisión y las dificultades que ellas tienen para acceder a los pocos espacios que logran ocupar.
En los últimos treinta años, sin lugar a dudas, se ha producido un cambio en los paradigmas. Sin embargo, gran parte de las actividades de nuestras sociedades siguen estando absolutamente masculinizadas, más aún si miramos las actividades vinculadas a la vida pública y política. En este sentido, la posibilidad de decidir en términos de democracia paritaria, se ve limitada.
De esta manera, el presente trabajo intenta realizar un recuento de las medidas afirmativas llevadas adelante en el nivel nacional y subnacional en términos de calidad democrática, pensando principalmente cuáles son los desafíos que quedan hacia el futuro.