bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative discussion of decision-making model based on complex cubic picture fuzzy information and geometric aggregation operators with applications
Authors: Tanoli Muhammad Naeem Khan , Gulistan Muhammad , Amin Fazli , Al-Shamiri Mohammed M. 
Published: October 2023

AbstractThis article presents a novel concept of complex cubic picture fuzzy sets (CCPFS) and introduces one more new idea of complex interval-valued picture fuzzy sets (CIVPFS) as foundational framework of CCPFS. The proposed CCPFS combines CIVPFS and complex picture fuzzy sets (CPFS), where CPFS extends the complex intuitionistic fuzzy set by incorporating a neutral membership degree. This unique model offers an expanded range of values using degrees of membership, neutral membership, and non-membership, within the unit disk of a complex plane. Additionally, we introduce two more new ideas of internal complex cubic picture fuzzy sets (ICCPFS) and external complex cubic picture fuzzy sets (ECCPFS) to further enhance the versatility of the approach. To facilitate practical applications, complement, score, and accuracy functions are developed and defined for CCPFS. Moreover, three types of averaging aggregation operators based on complex cubic picture fuzzy sets are introduced, including complex cubic picture fuzzy weighted geometric (CCPFWG) operators, complex cubic picture fuzzy ordered weighted geometric (CCPFOWG) operator, and complex cubic picture fuzzy hybrid weighted geometric (CCPFHWG) operator. The CCPFHWG operator generalizes both CCPFWG and CCPFOWG operators, providing a comprehensive framework for aggregating complex cubic picture fuzzy data. To demonstrate the practicality of the proposed approach, a multi-criteria decision-making (MCDM) problem is presented, showcasing its effectiveness in addressing today's complex decision structures. The utilization of complex cubic picture fuzzy sets and the corresponding aggregation operators in MCDM highlights their applicability and relevance in tackling real-world complexities.
Goal Directedness and the Field Concept
Authors: Babcock Gunnar , McShea Daniel W. 
Published: October 2023

AbstractA long-standing problem in understanding goal-directed systems has been the insufficiency of mechanistic explanations to make sense of them. This article offers a solution to this problem. It begins by observing the limitations of mechanistic decompositions when it comes to understanding physical fields. We argue that introducing the field concept, as it has been developed in field theory, alongside mechanisms is able to provide an account of goal directedness in the sciences.
Better than Best: Epistemic Landscapes and Diversity of Practice in Science
Authors: Wu Jingyi 
Published: October 2023

AbstractWhen solving a complex problem in a group, should group members always choose the best available solution that they are aware of? In this paper, I build simulation models to show that, perhaps surprisingly, a group of agents who individually randomly follow a better available solution than their own can end up outperforming a group of agents who individually always follow the best available solution. This result has implications for the feminist philosophy of science and social epistemology.
How Forced Switches Reveal Switching Costs: Evidence from the Loan Market
Authors: Liaudinskas Karolis 
Published: October 2023

AbstractThis article proposes a novel way to estimate consumer switching costs and uses Lithuanian credit register data and two bank closures to provide this estimate for the loan market. I show that when a distressed bank’s closure forced firms to switch, they started borrowing at lower interest rates instantly and permanently and that this drop revealed the lower bound of firms’ ex ante switching costs. A healthy bank’s closure showed no such effect. The article’s findings suggest that distressed banks hold up and overcharge firms and that by closing and resolving such banks with good-bank/bad-bank separation regulators can improve firm financing.
Welfare attitudes in a crisis: How COVID exceptionalism undermined greater solidarity
Authors: de Vries Robert , Geiger Ben Baumberg , Scullion Lisa , Summers Kate , Edmiston Daniel , Ingold Jo , Robertshaw David , Young David 
Published: October 2023

Abstract
COVID-19 had the potential to dramatically increase public support for welfare. It was a time of apparent increased solidarity, of apparently deserving claimants, and of increasingly widespread exposure to the benefits system. However, there are also reasons to expect the opposite effect: an increase in financial strain fostering austerity and self-interest, and thermostatic responses to increasing welfare generosity. In this paper, we investigate the effects of the pandemic on attitudes towards working-age unemployment benefits in the UK using a unique combination of data sources: (i) temporally fine-grained data on attitudinal change over the course of the pandemic; and (ii) a novel nationally representative survey contrasting attitudes towards pandemic-era and pre-pandemic claimants (including analysis of free-text responses). Our results show that the pandemic prompted little change in UK welfare attitudes. However, we also find that COVID-era unemployment claimants were perceived as substantially more deserving than those claiming prior to the pandemic. This contrast suggests a strong degree of ‘COVID exceptionalism’ – with COVID claimants seen as categorically different from conventional claimants, muting the effect of the pandemic on welfare attitudes overall.
Is undisciplined behavior antithetical to cooperation, or is it part and parcel of it?
Authors: Syme Kristen L. 
Published: October 2023

Abstract
This commentary raises three points in response to the target article. First, what appear to be victimless behaviors in highly individualistic, post-industrial societies might have a direct impact on group members in small-scale societies. Second, many societies show marked tolerance or ambivalence toward intemperate behavior. Third, undisciplined behavior is not antithetical to cooperation but can be used to cooperative ends.
Are we all implicit puritans? New evidence that work and sex are intuitively moralized in both traditional and non-traditional cultures
Authors: Tierney Warren , Cyrus-Lai Wilson , Uhlmann Eric Luis 
Published: October 2023

Abstract
Contradicting our earlier claims of American moral exceptionalism, recent self-replication evidence from our laboratory indicates that implicit puritanism characterizes the judgments of people across cultures. Implicit cultural evolution may lag behind explicit change, such that differences between traditional and non-traditional cultures are greater at a deliberative than an intuitive level. Not too deep down, perhaps we are all implicit puritans.
The puritanical moral contract: Purity, cooperation, and the architecture of the moral mind
Authors: Fitouchi Léo , André Jean-Baptiste , Baumard Nicolas 
Published: October 2023

Abstract
Commentators raise fundamental questions about the notion of purity (sect. R1), the architecture of moral cognition (sect. R2), the functional relationship between morality and cooperation (sect. R3), the role of folk-theories of self-control in moral judgment (sect. R4), and the cultural variation of morality (sect. R5). In our response, we address all these issues by clarifying our theory of puritanism, responding to counter-arguments, and incorporating welcome corrections and extensions.
Signs of character: a signalling model of Hume’s theory of moral and immoral actions
Authors: Tarar Ahmer 
Published: October 2023

AbstractIn A Treatise of Human Nature, Hume argues that morality pertains primarily to character, and that actions have moral content only to the extent that they signal good or bad character. I formalize his signalling theory of moral/immoral actions using simple game-theoretic models. Conditions exist under which there is a separating equilibrium in which actions do indeed credibly signal character, but conditions also exist in which there is only a pooling or semi-separating equilibrium. A tradeoff is identified between the signalling value of actions, and the consequentialist goal of incentivizing all character types to choose beneficial actions.
Structure of fine Selmer groups over -extensions
Authors: LIM MENG FAI 
Published: October 2023

AbstractThis paper is concerned with the study of the fine Selmer group of an abelian variety over a
$\mathbb{Z}_{p}$
-extension which is not necessarily cyclotomic. It has been conjectured that these fine Selmer groups are always torsion over
$\mathbb{Z}_{p}[[ \Gamma ]]$
, where
$\Gamma$
is the Galois group of the
$\mathbb{Z}_{p}$
-extension in question. In this paper, we shall provide several strong evidences towards this conjecture. Namely, we show that the conjectural torsionness is consistent with the pseudo-nullity conjecture of Coates–Sujatha. We also show that if the conjecture is known for the cyclotomic
$\mathbb{Z}_{p}$
-extension, then it holds for almost all
$\mathbb{Z}_{p}$
-extensions. We then carry out a similar study for the fine Selmer group of an elliptic modular form. When the modular forms are ordinary and come from a Hida family, we relate the torsionness of the fine Selmer groups of the specialization. This latter result allows us to show that the conjectural torsionness in certain cases is consistent with the growth number conjecture of Mazur. Finally, we end with some speculations on the torsionness of fine Selmer groups over an arbitrary p-adic Lie extension.
Le programme Participe-présent auprès d’aînés vivant avec une problématique de santé mentale ou des difficultés psychosociales affectant leur participation communautaire : résultats d’une étude pilote sur sa faisabilité
Authors: Aubin Ginette , Parisien Manon , Billette Véronique , Beauchamp Julie , Smele Sandra 
Published: October 2023

RésuméLes aînés qui vivent avec des problèmes de santé mentale ou des difficultés psychosociales sont souvent isolés et marginalisés. Le programme Participe-présent a été développé dans le but de promouvoir leur participation communautaire. Les objectifs de cette étude étaient de 1) décrire la pertinence, l’acceptabilité, et la faisabilité du programme lors de sa mise à l’essai et 2) d’explorer les bienfaits et les effets à court-terme du programme pour les participants. Vingt-trois aînés, quatre animateurs et trois responsables provenant de quatre organismes ont participé à l’étude. Les aînés ont été satisfaits de leur expérience de participation au programme et ont rapporté une meilleure connaissance des ressources et une plus grande satisfaction à l’égard de leur vie sociale. Les animateurs et les responsables d’organismes ont souligné l’adaptabilité de Participe-présent aux besoins de leur clientèle et à leur contexte de pratique, et ont identifié les facilitateurs et les obstacles à sa mise en œuvre. D’autres études mèneront à des recommandations favorisant le succès de la mise en œuvre de Participe-présent dans différents contextes.
Influenza hospitalisations in Spain between the last influenza and COVID-19 pandemic (2009–2019)
Authors: Canelas-Fernández Javier , Mazagatos Clara , Delgado-Sanz Concepción , Larrauri Amparo 
Published: October 2023

Abstract
Knowing the burden of severe disease caused by influenza is essential for disease risk communication, to understand the true impact of vaccination programmes and to guide public health and disease control measures. We estimated the number of influenza-attributable hospitalisations in Spain during the 2010–2011 to 2019–2020 seasons – based on the hospitalisations due to severe acute respiratory infection (SARI) in Spain using the hospital discharge database and virological influenza information from the Spanish Influenza Sentinel Surveillance System (SISSS). The weekly numbers of influenza-attributable hospitalisations were calculated by multiplying the weekly SARI hospitalisations by the weekly influenza virus positivity, obtained from the SISSS in each season, stratified by age group and sex. The influenza-related hospitalisation burden is age-specific and varies significantly by influenza season. People aged 65 and over yielded the highest average influenza-attributable hospitalisation rates per season (615.6 per 100,000), followed by children aged under 5 (251.2 per 100,000). These results provide an essential contribution to influenza control and to improving existing vaccination programmes, as well as to the optimisation and planning of health resources and policies.
Machine Learning for Detecting Virus Infection Hotspots Via Wastewater‐Based Epidemiology: The Case of SARS‐CoV‐2 RNA
Authors: Zehnder Calvin , Béen Frederic , Vojinovic Zoran , Savic Dragan , Torres Arlex Sanchez , Mark Ole , Zlatanovic Ljiljana , Abebe Yared Abayneh 
Published: October 2023

AbstractWastewater‐based epidemiology (WBE) has been proven to be a useful tool in monitoring public health‐related issues such as drug use, and disease. By sampling wastewater and applying WBE methods, wastewater‐detectable pathogens such as viruses can be cheaply and effectively monitored, tracking people who might be missed or under‐represented in traditional disease surveillance. There is a gap in current knowledge in combining hydraulic modeling with WBE. Recent literature has also identified a gap in combining machine learning with WBE for the detection of viral outbreaks. In this study, we loosely coupled a physically‐based hydraulic model of pathogen introduction and transport with a machine learning model to track and trace the source of a pathogen within a sewer network and to evaluate its usefulness under various conditions. The methodology developed was applied to a hypothetical sewer network for the rapid detection of disease hotspots of the disease caused by the SARS‐CoV‐2 virus. Results showed that the machine learning model's ability to recognize hotspots is promising, but requires a high time‐resolution of monitoring data and is highly sensitive to the sewer system's physical layout and properties such as flow velocity, the pathogen sampling procedure, and the model's boundary conditions. The methodology proposed and developed in this paper opens new possibilities for WBE, suggesting a rapid back‐tracing of human‐excreted biomarkers based on only sampling at the outlet or other key points, but would require high‐frequency, contaminant‐specific sensor systems that are not available currently.
Deepening of Southern Ocean Gateway Leads to Abrupt Onset of a Deep‐Reaching Meridional Overturning Circulation
Authors: Xing Qianjiang , Klocker Andreas , Munday David , Whittaker Joanne 
Published: October 2023

AbstractDuring the Eocene and the Eocene‐Oligocene transition, the lower cell of the meridional overturning circulation (MOC), associated with bottom water formation, underwent changes associated with the geological evolution of Southern Ocean gateways. These are important for the Cenozoic climate transition from Greenhouse to Icehouse, but their dynamics still remain elusive. We demonstrate, using an idealized eddying ocean model, that the opening of a gateway leads to the abrupt onset of a vigorous, deep‐reaching, MOC. This MOC has a maximum transport for a shallow gateway, and decreases with further deepening of the gateway. This abrupt change in the MOC can be explained through the ability with which standing meanders—turbulent features located downstream of the gateway—can induce deep vertical heat transport at high latitudes where bottom waters are produced. Our results demonstrate the crucial role of turbulent processes in setting the strength of the global ocean's deep‐reaching MOC.
The Temporal Brightening of Uranus' Northern Polar Hood From HST/WFC3 and HST/STIS Observations
Authors: James Arjuna , Irwin Patrick G. J. , Dobinson Jack , Wong Michael H. , Tsubota Troy K. , Simon Amy A. , Fletcher Leigh N. , Roman Michael T. , Teanby Nick A. , Toledo Daniel , Orton Glenn S. 
Published: October 2023

AbstractHubble Space Telescope Wide‐Field Camera 3 (HST/WFC3) observations spanning 2015 to 2021 confirm a brightening of Uranus' north polar hood feature with time. The vertical aerosol model of Irwin et al. (2023, https://doi.org/10.1038/s41550-023-02047-0) (IRW23), consisting of a deep haze layer based at ∼5 bar, a 1–2 bar haze layer, and an extended haze rising up from the 1–2 bar layer, was applied to retrievals on HST Space Telescope Imaging Spectrograph (STIS) (HST/STIS) observations (Sromovsky et al., 2014, 2019, https://doi.org/10.1016/j.icarus.2014.05.016, https://doi.org/10.1016/j.icarus.2018.06.026) revealing a reduction in cloud‐top CH4 volume mixing ratio (VMR) (i.e., above the deep ∼5 bar haze) by an average of 0.0019 ± 0.0003 between 40–80◦N (∼10% average reduction) from 2012 to 2015. A combination of latitudinal retrievals on the HST/WFC3 and HST/STIS data sets, again employing the IRW23 model, reveal a temporal thickening of the 1–2 bar haze layer to be the main cause of the polar hood brightening, finding an average increase in integrated opacity of 1.09 ± 0.08 (∼33% increase) at 0.8 µm north of ∼45°N, concurrent with a decrease in the imaginary refractive index spectrum of the 1–2 bar haze layer north of ∼40°N and longwards of ∼0.7 µm. Small contributions to the brightening were found from a thickening of the deep aerosol layer, with an average increase in integrated opacity of 0.6 ± 0.1 (58% increase) north of 45°N between 2012 and 2015, and from the aforementioned decrease in CH4 VMR. Our results are consistent with the slowing of a stratospheric meridional circulation, exhibiting subsidence at the poles.
Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study
Authors: Fattizzo Bruno , Gurnari Carmelo , Cassanello Giulio , Bortolotti Marta , Awada Hussein , Giammarco Sabrina , Consonni Dario , Sica Simona , Gandhi Shreyans , Trikha Roochi , Large Joanna , Salter Sarah , Maciejewski Jaroslaw P. , Barcellini Wilma , Kulasekararaj Austin G. 
Published: October 2023

AbstractNon-severe aplastic anemia is a rare bone marrow failure disorder characterized by variable degrees and combination of cytopenias, with limited data on management and outcome. We describe a large multicentric series of 259 patients, focusing on clinical and molecular features, treatment, evolution, and survival. The majority required treatment with cyclosporine (CyA) alone (N = 84) or in combination with anti-thymocyte globulin (ATG,44) or eltrombopag (20), eltrombopag alone (10), or others (25) including androgens. Similar outcomes were observed across different strategies, with a 6-month overall response rate of 73% for CyA, 74% for ATG plus CyA, 68% for CyA plus eltrombopag, 87% for eltrombopag, and 79% for others. Notably, 56 patients (39%), mainly receiving CyA plus eltrombopag, achieved a trilineage response (p = 0.02). Progression to myeloid neoplasms was limited (8%) and not related to mutational status. Hemolytic PNH developed in 10% of cases, being predicted by detection of small clones at diagnosis. Survival was negatively impacted by age, male gender, LDH, platelets/erythrocyte transfusion need, and somatic mutations by NGS, and positively by higher neutrophils at diagnosis, PNH clones, and trilineage response at 6 and 12 months. Multivariable analysis confirmed the detrimental role of age and the favorable association with PNH clone and trilineage response at 6 months.
S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer
Authors: Srivastava K. , Lines K. E. , Jach D. , Crnogorac-Jurcevic T. 
Published: October 2023

AbstractWe have previously shown that expression of S100PBP, an S100P binding partner, gradually decreases during progression of pancreatic ductal adenocarcinomas (PDAC). Here, we show that loss of S100PBP leads to oncogenic transformation of pancreatic cells; after deregulation of S100PBP expression, both in silico and in vitro analyses highlighted alterations of genes known to modulate cytoskeleton, cell motility and survival. Overexpression of S100P reduced S100PBP expression, while co-immunoprecipitation indicated the interaction of S100P with S100PBP-p53-ubiquitin protein complex, likely causing S100PBP degradation. The doxycycline-induced KrasG12D activation resulted in decreased S100PBP levels, while low-dose treatment with HDAC inhibitor MS-275 rescued its expression in both human and mouse PDAC cell lines. This indicates KrasG12D as an upstream epigenetic regulator of S100PBP. Finally, analysis of TCGA PanCancer Atlas PDAC datasets demonstrated poor prognosis in patients with high S100P and low S100PBP expression, suggesting that S100PBP is a novel tumour suppressor gene with potential clinical utility.
Macroscopic waves, biological clocks and morphogenesis driven by light in a giant unicellular green alga
Authors: Afik Eldad , Liu Toni J. B. , Meyerowitz Elliot M. 
Published: October 2023

AbstractA hallmark of self-organisation in living systems is their capacity to stabilise their own dynamics, often appearing to anticipate and act upon potential outcomes. Caulerpa brachypus is a marine green alga consisting of differentiated organs resembling leaves, stems and roots. While an individual can exceed a metre in size, it is a single multinucleated giant cell. Thus Caulerpa presents the mystery of morphogenesis on macroscopic scales in the absence of cellularization. The experiments reported here reveal self-organised waves of greenness — chloroplasts — that propagate throughout the alga in anticipation of the day-night light cycle. Using dynamical systems analysis we show that these waves are coupled to a self-sustained oscillator, and demonstrate their entrainment to light. Under constant conditions light intensity affects the natural period and drives transition to temporal disorder. Moreover, we find distinct morphologies depending on light temporal patterns, suggesting waves of chlorophyll could link biological oscillators to metabolism and morphogenesis in this giant single-celled organism.
MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
Authors: Cao He , Yang Panpan , Liu Jia , Shao Yan , Li Honghao , Lai Pinglin , Wang Hong , Liu Anling , Guo Bin , Tang Yujin , Bai Xiaochun , Li Kai 
Published: October 2023

AbstractAs the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is negatively regulated by myosin light chain 3. Myosin light chain 3 (MYL3) protein levels decline sharply in senescent chondrocytes of cartilages from model mice and osteoarthritis (OA) patients. Conditional deletion of Myl3 in chondrocytes significantly promoted, whereas intra-articular injection of adeno-associated virus overexpressing MYL3 delayed, OA progression in male mice. MYL3 deficiency led to enhanced clathrin-mediated endocytosis by promoting the interaction between myosin VI and clathrin, further inducing the internalization of Notch and resulting in activation of Notch signaling in chondrocytes. Pharmacologic blockade of clathrin-mediated endocytosis-Notch signaling prevented MYL3 loss-induced chondrocyte senescence and alleviated OA progression in male mice. Our results establish a previously unknown mechanism essential for cellular senescence and provide a potential therapeutic direction for OA.