bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics Associated with Substance Use and Non-use Among Street Children in Delhi, India: A Community-based Cross-sectional Epidemiological Study
Authors: Dhawan Anju , Mishra Ashwani Kumar , Chatterjee Biswadip , Bhatia Gayatri , Ambekar Atul , Agarwal Alok , Bhargava Rachna , Chopra Anita 
Published: October 2023

Background: Street children are vulnerable to adverse health and risk behaviors and drug use. Substance use among street children has been well documented in several countries. This study reports sociodemographic and peer, family, and stress-related factors associated with substance use and non-use in a representative sample of street children of Delhi. Methods: This cross-sectional survey was conducted through six NGOs working with street children, using Respondent Driven Sampling, in nine districts of Delhi (n = 766, 7–18 years). The multivariable model was developed by applying binary logistic regression analysis. Results: The rate of substance use was 49%. Significant association was found between substance use in the past year and increasing age [Odds Ratio: OR (95% Confidence Interval)] [1.22(1.12,1.33)], male sex [4.34 (2.28,8.26)], lacking psychosocial support from family/relatives [3.27(1.84,5.80)], being engaged in earning from illegal sources, [3.04(1.75,5.29)], family use of substance [2.59(1.38,4.89)], presence of substance-using peers [29.86(14.38,62.01)], lack of non-drug-using peers [2.35(1.46,3.79)], and not possessing basic amenities [2.26(1.31,3.93)]. Conclusion: Multiple modifiable factors exist within the family and peer group, including risk and protective factors or a consequence of substance use. Some challenges in the form of difficulty in reaching out to them and poor treatment seeking by those using substances warrant intensification in both primary and secondary prevention initiatives.
Development of Ag NPs/allantoin loaded PCL/GEL electrospun nanofibers for topical wound treatment
Authors: Doostmohammadi Mohsen , Niknezhad Seyyed Vahid , Forootanfar Hamid , Ghasemi Younes , Jafari Elham , Adeli-Sardou Mahboubeh , Amirsadeghi Armin , Ameri Alieh 
Published: October 2023

In the present study, the allantoin and silver nanoparticle (Ag NPs) loaded poly caprolactone/gelatin (PCL/GEL) nanofibers produced using electrospinning technique and their cyto-compatibility and wound healing activity were evaluated in vitro and in vivo. The SEM imaging revealed diameters of 278.8 ± 10 and 240.6 ± 12 nm for PCL/GEL/Ag NPs and PCL/GEL/Ag NPs/allantoin scaffolds. The Ag NPs entrapment into scaffolds was evaluated by FTIR analysis and EDX mapping. Both scaffolds containing Ag NPs and Ag NPs/allantoin exhibited valuable wound healing activity in Wistar rat animal model. The profound granulation tissue formation, high collagen deposition in coordination with low level of edema and inflammatory cells in Ag NPs/allantoin loaded scaffolds resulted in complete and mature re-epithelialization in giving the healing score (12 out of 12) equal to positive control group to the wounds treated with these scaffolds. It was concluded that the Ag NPs/allantoin loaded scaffolds regarding to their good antibacterial activity and excellent wound healing activity could be introduced as new effective wound dressing materials.
“Eat Me! Eat Me! tounsi”: English in Tunisian linguistic landscapes beyond the official policy legislations
Authors: Helal Fethi 
Published: October 2023

Aims and objectives: This paper investigates the diffusion of English into the linguistic ecologies of Tunisia, an Expanding Outer Circle society in North Africa. It analyzes the language practices of Tunisian business operators in five commercial localities in metropolitan Tunis. The paper focuses, in particular, on the uses of English and its interaction with Tunisia’s dominant languages, the ways the resources of English are locally understood and deployed and the intersection of the emerging “language regime” (Kroskrity, 2000) with the official linguistic landscapes policies and the wider sociohistorical, political, and economic conditions of the country. Methodology and data: Detailed discourse-ethnographic analysis of 363 linguistic landscape signs collected from 5 commercial districts in metropolitan Tunis. Findings and conclusions: The findings indicated the emergence of a bottom-up English-led public signage communicating a global corporate ideology circumventing the official language policies mandating the use and visibility of Modern Standard Arabic in public signage. However, this English-led public posting is intertwined in complex ways with Tunisia’s dominant languages, resulting in translanguaging, linguistic puns, the commodification of vernacular forms of communication as well as (supra)national and aesthetic identity markers. Originality: Tunisia, a traditionally constructed Francophone country moving toward English, is very little explored in the major Global English(es) paradigms. The paper focuses on the possible ideological, economic, and cultural changes engendered by English and connects these changes to the global socioeconomic, political, and cultural transformations undergone by the country over the last decades.
Antifungal Potential and Chemical Composition of Chamaecyparis formosensis and Chamaecyparis obtusa var. formosana Essential Oils in Liquid and Vapor Phases Against 4 Fungal Species
Authors: Chen Ying-Ju , Yeh Ruo-Yun , Cheng Sen-Sung 
Published: October 2023

Background Only a few studies have investigated the bioactivity of the essential oils (EOs) of Chamaecyparis formosensis and C. obtusa var. formosana, which are endemic to Taiwan. The wood and leaf EOs extracted from C. obtusa var. formosana had anti-inflammatory and antitermitic effects, respectively, and the twig EO extracted from C. formosensis inhibited the growth of Fusarium oxysporum, Pestalotiopsis funerea, and Ganoderma australe. Methods A poisoned food technique was used to evaluate the antifungal effects of wood and leaf EOs extracted from C. formosensis and C. obtusa var. formosana on brown rot fungus, white rot fungus, and mold. A phytatray chamber assay was conducted to investigate the antifungal activities of the EOs in the vapor phase. Gas chromatography-mass spectrometry was used to examine the chemical constituents of both EOs. Results The leaf EO extracted from C. formosensis primarily contained monoterpene hydrocarbons, whereas the leaf EO extracted from C. obtusa var. formosana primarily contained monoterpene and sesquiterpene hydrocarbons. The wood EOs extracted from C. formosensis and C. obtusa var. formosana primarily contained sesquiterpene hydrocarbons and oxygenated sesquiterpenes. These results indicated that the wood EOs had higher antifungal activity in the liquid phase, whereas the leaf EOs had higher antifungal activity in the vapor phase. Conclusion Wood EOs extracted from C. formosensis and C. obtusa var. formosana have strong antifungal effects against Gloeophyllum trabeum, Lenzites betulina, Trametes versicolor, and Trichoderma sp. Compared with wood EOs, leaf EOs have a greater inhibitory effect on mycelial growth in the vapor phase. In both the liquid and vapor phases, the EOs extracted from C. formosensis and C. obtusa var. formosana serve as effective antifungal agents against pathogenic fungi. Further research is required to elucidate the mechanisms underlying the antifungal activities of EOs in different phases and explore their potential applications.
Designing Worthy Waiting Spaces: A Cross-Cultural Study of Waiting Room Features and Their Impact on Women’s Affective States
Authors: Huber Amy , Bailey Rachel 
Published: October 2023

Objective: This study examines the impact of ambulatory waiting room characteristics on patients’ emotional states and investigates whether these states are universally experienced or influenced by social and cultural factors among women aged 18–35 from the three largest demographic groups in the United States: Black, Hispanic/Latina, and White. Background: Patients typically spend more time waiting for routine medical appointments than receiving care, and evidence suggests that waiting can reinforces power dynamics that benefit privileged groups, leading to different experiences for minority women seeking preventative care. Still, literature addressing the impact of waiting areas is largely limited to universal measures, and little is known about how different ethnic/race groups respond to waiting spaces. Methods: This inquiry used a questionnaire assessing 15 waiting room characteristics and testing four variables (furniture arrangement, room-scale, color saturation, and quantity of positive distractions) in a 2 × 3 quasiexperiment using a fractional randomized block design with 24 waiting room images. Findings: Responses from 1,114 participants revealed mutual preferences for sociopetal seating, positive distractions, neutral colors, and welcoming and calming environments. Yet, Black participants indicated significantly greater importance in seeing ethnically/racially similar patients and healthcare providers and strategies that promote transparency, including image-based provider directories and views into the clinic. Conclusion: By investigating the impact of the waiting room environment on patient affect and comparing perceptions across three demographic groups of women, this study offers insights into potential strategies for improving access to preventative care services by creating more welcoming ambulatory care waiting environments.
Multidisciplinary Support To Access living donor Kidney Transplant (MuST AKT): A Clinical Research Protocol for a Pilot Randomized Controlled Trial to Increase Living Kidney Donation
Authors: Selzler Anne-Marie , Davoodi Parastoo Molla , Klarenbach Scott , Lam Ngan N. , Smith Terry , Ackroyd Abigail , Wiebe Natasha , Corradetti Bonnie , Ferdinand Sharron , Iyekekpolor Dorothy , Smith Gordon , Verdin Nancy , Bello Aminu K. , Wen Kevin , Shojai Soroush ,   on behalf of the Multidisciplinary Support To Access living donor Kidney Transplant (MuST AKT) Research Group
Published: October 2023

Background: Living donor kidney transplantation (LDKT) is the optimal treatment for eligible patients with kidney failure, although it is underutilized. Contextually tailored patient- and family-centered interventions may be effective to increase LDKT. Objective: We outline a protocol to test the feasibility of the Multidisciplinary Support To Access living donor Kidney Transplant (MuST AKT) intervention designed to increase LDKT. Design: Non-blinded single-center pilot randomized controlled trial with a qualitative interview component. Setting: Academic transplant referral center in Northern Alberta Region with a population of more than 2 million in its catchment area. Patients: English-speaking patients of the age range 18 to 75 years who are referred for kidney transplantation are eligible to participate. Measurements: Feasibility will be assessed by indicators of recruitment, retention, and completion rates, treatment fidelity, adherence to intervention, engagement in intervention, and acceptability. Methods: Participants will be randomly assigned 1:1 to either standard care (control) or the experimental group who receive standard care plus the MuST AKT intervention, a person-centered program designed to assist and enable the kidney transplant candidate to achieve what is required to receive an LDKT. The intervention consists of an introductory session and 4 intervention sessions delivered in-person or virtually. Limitations: Inferences cannot be drawn regarding the efficacy/effectiveness of the MuST AKT intervention. This study is non-blinded. Conclusions: This pilot study is the first step in our broader initiative to increase LDKT in our health care jurisdiction. The results of this study will be used to inform the development of a future definitive randomized controlled trial. Trial registration number: NCT04666545.
Predicting Progression in Adolescent Idiopathic Scoliosis at the First Visit by Integrating 2D Imaging and 1D Clinical Information
Authors: Chu Kenneth , Kuang Xihe , Cheung Prudence W. H. , Li Sofia , Zhang Teng , Cheung Jason Pui Yin 
Published: October 2023

Study Design Retrospective observational study. Objectives The prediction of curve progression in patients with adolescent idiopathic scoliosis (AIS) remains an unresolved area in orthopedic surgery. To make a rapid meaningful prediction, easily accessible multi-dimensional data at the patient’s first consultation should be used. Current studies use clinical growth parameters and numerical values extracted from radiographs to compile a predictive model, leaving out the radiographs themselves. Such practice inevitably wastes a lot of information. Thus, this study aims to create a neural network that can predict AIS progression among patients with curves indicated for bracing by integrating both one-dimensional (1D) clinical and two-dimensional (2D) radiological data collected at the patient’s first visit in a fully automated manner. Methods 513 idiopathic scoliosis patients indicated for and managed with bracing orthosis were recruited. After exclusion, 463 patients were included in deep learning analysis. Processed first-visit growth parameters and posteroanterior radiographs are used as training inputs and the curve progression outcomes obtained in follow ups are used as binary training outputs. The CapsuleNet architecture was modified and trained accordingly to make a prediction. Results The final model achieved 90% sensitivity with an overall accuracy of 73.9% in the prediction of AIS in-brace curve progression by using first-visit multi-dimensional data, outperforming conventional convolutional neural networks. Conclusions This first-ever multidimensional-input model shows promise in serving as a screening tool for AIS in-brace curve progression. The incorporation of such a model into routine AIS diagnostic pipeline can assist orthopedics clinicians in personalizing the most appropriate management for each patient.
Experience of Parents with Children Undergoing Chemotherapy
Authors: Alghamdi Salmah , Alqurashi Afnan , Almarbae Nura , Fadul Yara , Alharbi Maha , Bashammakh Reham 
Published: October 2023

Background The care of a child receiving chemotherapy has a significant impact on the parents and family structure, which has been explored in depth in a few studies in Saudi Arabia. The purpose of this study is to further explore the lived experiences of Saudi Arabian parents in caring for their children receiving chemotherapy. Methodology A qualitative descriptive design was used in this study with a sample of 17 parents of children receiving chemotherapy. The participants were recruited using the snow-balling technique throughout the community, as well as from the University Hospital, Pediatric Oncology Department. The data were collected via in-person and virtual methods using semi-structured, open-ended interviews and analyzed using thematic analysis. Results The findings of the study were placed into two main themes: family experience and stages of disease. Family experiences include the parents and siblings’ experiences. The stages of disease include three sub-themes: the pre-diagnosis phase, diagnosis phase, and treatment phase. Conclusion The cancer journey had a huge impact on the parents and siblings. The study revealed important findings related to the experiences during the stages of diseases and lived experiences of parents and siblings including psychological, physiological, social, and financial impacts.
Serum uric acid and prognosis of ischemic stroke: Cohort study, meta-analysis and Mendelian randomization study
Authors: Zhong Jinghui , Cai Huan , Zhang Zhizhong , Wang Jinjing , Xiao Lulu , Zhang Pan , Xu Yingjie , Tu Wenqing , Zhu Wusheng , Liu Xinfeng , Sun Wen 
Published: October 2023

Introduction: The role of serum uric acid (UA) levels in the functional recovery of ischemic stroke remains uncertain. To evaluate whether UA could predict clinical outcomes in patients with ischemic stroke. Patients and methods: A three-stage study design was employed, combining a large-scale prospective cohort study, a meta-analysis and a Mendelian randomization (MR) analysis. Firstly, we conducted a cohort study using data from the Nanjing Stroke Registry Program (NSRP) to assess the association between UA levels and 3-month functional outcomes in ischemic stroke patients. Secondly, the meta-analysis was conducted to integrate currently available cohort evidence. Lastly, MR analysis was utilized to explore whether genetically determined UA had a causal link to the functional outcomes of ischemic stroke using summary data from the CKDGen and GISCOME datasets. Results: In the first stage, the cohort study included 5631 patients and found no significant association between UA levels and functional outcomes at 3 months after ischemic stroke. In the second stage, the meta-analysis, including 10 studies with 14,657 patients, also showed no significant association between UA levels and stroke prognosis. Finally, in the third stage, MR analysis using data from 6165 patients in the GISCOME study revealed no evidence of a causal relationship between genetically determined UA and stroke functional outcomes. Discussion and conclusion: Our comprehensive triangulation approach found no significant association between UA levels and functional outcomes at 3 months after ischemic stroke.
Self-assembled micro and nano rod-shaped porphyrin@Bi12O17Cl2 composite as an efficient photocatalyst for degradation of organic contaminants
Authors: Ogbeifun Osemeikhian , Tichapondwa Shepherd M. , Chirwa Evans M. N. 
Published: October 2023

AbstractBi12O17Cl2 is a potential photocatalyst in practical applications due to its excellent photostability, visible light activity, and competitive bandgap energy. However, the fast recombination of photogenerated charge carriers makes it impractical for pollution mitigation. Recently, aggregated porphyrins have emerged as photosensitizers in light-dependent applications such as photocatalysis. Although Bi12O17Cl2 and porphyrin can function as separate photocatalysts, their photocatalytic properties in terms of visible light adsorption, charge separation and transport, can be improved when they are combined to form heterostructure. In this study, rod-shaped aggregated 5,10,15, 20-Tetrakis (4-carboxyphenyl) porphyrin was synthesized by CTAB-assisted, self-assembly strategy and Bi12O17Cl2 by a facile microwave method. The porphyrin and Bi12O17Cl2 were combined to generate a series of x%Porphyrin@Bi12O17Cl2 having 0.02% wt., 0.1% wt., 0.4% wt., 1% wt. and 10% wt. as compositions of porphyrin. The materials’ photocatalytic degradation efficiency was tested on Rhodamine B dye as a representative pollutant. The best and worst performances were reported for 1%Porphyrin@Bi12O17Cl2 and 10%Porphyrin@Bi12O17Cl2, respectively, which are 3.1 and 0.5 times increases in efficiency compared to pure Bi12O17Cl2. From the radical trapping experiment, electrons and superoxide were the dominant reactive species in the degradation process. The enhanced photocatalytic capability of the materials was attributed to the photosensitizing property of porphyrin and the heterojunction formation, which promotes the separation of photogenerated charge carriers. A plausible step-scheme (S-scheme) was proposed for the photocatalytic degradation mechanism. The S-scheme provided the high redox potential of the photogenerated charge carriers. The findings herein offer a new option for improving the photocatalytic performance of Bi12O17Cl2 for environmental applications through the photosensitization strategy.
Graphical abstract
Preparation, characterization, and magnetic resonance imaging of Fe nanowires
Authors: Cao Xiaoming , Hu Shike , Zheng Hua , Mukhtar Aiman , Wu KaiMing , Gu Liyuan 
Published: October 2023

AbstractA facile template method was employed to synthesize Fe nanowires of different sizes, dimensions. Comprehensive analyses were conducted to explore their morphology, structure, composition, and magnetic properties. The surface of as-prepared Fe nanowires was modified with SiO2 by sol–gel method to improve the dispersion of as-prepared Fe nanowires in aqueous solution. Furthermore, the relaxation properties, biocompatibility and in vivo imaging abilities of the Fe@SiO2 nanowires were evaluated. The study revealed that the SiO2-coated Fe nanowires functioned effectively as transverse relaxation time (T2) contrast agents (CAs). Notably, as the length of the Fe@SiO2 nanowires increased, their diameter decreased, leading to a higher the transverse relaxivity (r2) value. Our study identified that among the Fe nanowires synthesized, the Fe3@SiO2 nanowires, characterized by a diameter of around 30 nm and a length of approximately 500 nm, exhibited the highest r2 value of 59.3 mM−1 s−1. These nanowires demonstrated good biocompatibility and non-toxicity. Notably, upon conducting small animal imaging a 1.5 T with Sprague–Dawley rats, we observed a discernible negative enhancement effect in the liver. These findings indicate the promising potential of Fe@SiO2 nanowires as T2 CAs, with the possibility of tuning their size for optimized results.
Diminished ovarian reserve causes adverse ART outcomes attributed to effects on oxygen metabolism function in cumulus cells
Authors: Zhang Cong , Song Shi , Yang Ming , Yan Liying , Qiao Jie 
Published: October 2023

Abstract
Background
Declining oocyte quality in women with advanced age has been a major impediment to assisted reproductive treatments’ (ART) success rate. However, aging is often accompanied by a diminished ovarian reserve (DOR). Cumulus cells (CCs) are known to play an important role in the development and maturation of oocytes, and the quality of CCs actually reflects the quality of the oocyte. In this study, CCs were used to investigate the real reasons for the decline in oocyte quality in older women.

Methods
Ninety-nine CC samples were subdivided into 4 different groups according to the different age and ovarian reserve status. Other than clinical ART results, transcriptional expression profiles were performed in CCs to detect the differences.

Results
The results were that DOR, no matter in young or advanced age group, was found to be significantly associated with adverse ART outcomes. Of note, there were no statistically significant changes in ART outcomes in the group at advanced age with normal ovarian reserve (NOR), compared to the young with NOR. DOR induced a series of transcriptional variations in CCs commonly enriched in oxygen metabolism.

Conclusion
Our results revealed that the ART outcomes in advanced patients were attributable to the DOR. The oxygen metabolic changes may interfere with CCs’ function of supporting oocytes. This study can provide guidance for ART practice that not age but ovarian reserve status is the main predictor for ART outcomes, and ovarian reserve status should be timely assessed when the clinical manifestations are still mild in elderly women.