bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Surgical Management of NCAA Division 1 College Football Injuries Post COVID-19: A Single Institution Retrospective Review
Authors: Cohen Jacob L. , Cade William H. , Harrah Tanner C. , Costello Joseph P. , Kaplan Lee D. 
Published: January 2024

Abstract
Cohen, JL, Cade, WH, Harrah, TC, Costello II, JP, and Kaplan, LD. The surgical management of NCAA Division 1 college football injuries post COVID-19: A single institution retrospective review. J Strength Cond Res 38(5): 906–911, 2024—The unprecedented COVID-19 pandemic had a significant impact on college football operations, including athletes' training regimens. As a result of these changes, concern for increased injury susceptibility post COVID-19 regulations has become a point of discussion. The current study sought to evaluate the incidence of surgical injury among NCAA Division 1 college football players at the authors' institution during the first full season after start of the COVID-19 pandemic compared with previous years. Retrospective chart review was performed for all players who sustained injuries requiring surgery while a member of the NCAA Division 1 football program during the 2009–2021 seasons. A p-value of ≤0.05 was used to determine significance. A total of 23 surgical injuries occurred in 22 players during the 2021 season compared with 121 in 118 players in the 12 previous seasons combined (p = 0.0178; RR = 1.47). There was a significant increase in shoulder injuries (n = 13 vs. n = 31; p = <0.0001; RR = 3.05) and specifically a significant increase in labral tears (n = 10 vs. n = 30; p = 0.0003; RR = 2.74). No difference was seen in knee injuries (n = 10 vs. n = 77; p = 0.27; RR = 1.35) and specifically no difference in anterior cruciate ligament injuries (n = 3 vs. n = 31; p = 0.77; RR = 1.17). This phenomenon is multifactorial in nature, but alterations to players' training and preparations because of the COVID-19 pandemic likely resulted in suboptimal conditioning, leading to the increased incidence of surgical injuries emphasizing the importance of adequate strength training and conditioning.
Determination of the Effective Fused Deposition Modeling Process Parameters on the Mechanical Properties of Carbon Fiber–Reinforced Polypropylene Parts
Authors: Eryildiz Meltem , Kosa Ergin , Yavuzer Bekir , Akgün İsmail Cem 
Published: January 2024

Abstract
Additive manufacturing is gaining popularity for producing components in industries such as automotive, aerospace, and medicine due to its potential to minimize material waste. Because the strength of the 3-D-printed part is so important, it’s crucial to do research and optimize process parameters to make the printed parts as strong as possible. This work focuses on the experimental investigation and discussion of the tensile and impact strength of parts made from carbon fiber–reinforced polypropylene (PP-CF) using the fused deposition modeling (FDM) technique. Various process parameters, including infill pattern, infill density, layer thickness, and build orientation, are examined on three different levels to determine their influence on the tensile and impact strength of the printed part. The outcomes of the analysis of variance (ANOVA) analysis reveal that infill density primarily affects impact strength, whereas layer thickness significantly influences tensile strength. The optimal combination of parameters leading to the maximum tensile and impact strength consists of a grid infill pattern, 60 % infill density, 0.36-mm layer thickness, and a 45° build orientation. Furthermore, fracture surface analysis is consistent with mechanical test results.
Alleviating hypertension by selectively targeting angiotensin receptor expressing vagal sensory neurons
Authors: Baumer-Harrison Caitlin , Elsaafien Khalid , Johnson Dominique N. , Aponte Jesus D. Peñaloza , de Araujo Alan , Patel Sagar , Bruce Erin , Harden Scott W. , Frazier Charles J. , Scott Karen A. , de Lartigue Guillaume , Krause Eric G. , de Kloet Annette D. 
Published: January 2024

Cardiovascular homeostasis is maintained, in part, by neural signals arising from arterial baroreceptors that apprise the brain of blood volume and pressure. Here, we test whether neurons within the nodose ganglia that express angiotensin type-1a receptors (referred to as NGAT1aR) serve as baroreceptors that differentially influence blood pressure (BP) in male and female mice. UsingAgtr1a-Cre mice and Cre-dependent AAVs to direct tdTomato to NGAT1aR, neuroanatomical studies revealed that NGAT1aRreceive input from the aortic arch, project to the caudal nucleus of the solitary tract (NTS), and synthesize mechanosensitive ion channels,Piezo-1/-2. To evaluate the functionality of NGAT1aR, we directed the fluorescent calcium indicator (GCaMP6s) or the light-sensitive channelrhodopsin-2 (ChR2) toAgtr1a-containing neurons. Two-photon intravital imaging inAgtr1a-GCaMP6s mice revealed that NGAT1aRcouple their firing to elevated BP, induced by phenylephrine (i.v.). Furthermore, optical excitation of NGAT1aRat their soma or axon terminals within the caudal NTS ofAgtr1a-ChR2 mice elicited robust frequency-dependent decreases in BP and heart rate, indicating that NGAT1aRare sufficient to elicit appropriate compensatory responses to vascular mechanosensation. Optical excitation also elicited hypotensive and bradycardic responses in ChR2-expressing mice that were subjected to deoxycorticosterone acetate (DOCA)-salt hypertension; however, the duration of these effects was altered, suggestive of hypertension-induced impairment of the baroreflex. Similarly, increased GCaMP6s fluorescence observed after administration of phenylephrine was delayed in mice subjected to DOCA-salt or chronic delivery of angiotensin-II. Collectively, these results reveal the structure and function of NGAT1aRand suggest that such neurons may be exploited to discern and relieve hypertension.Significance StatementHypertension is a major risk factor for cardiovascular disease and stroke, the 1stand 5thleading causes of death in the U.S. Half of the adult population is afflicted with hypertension, with many not having their condition under control with current treatment options. Thus, there is a need to discover novel targets and develop new antihypertensive therapeutics. Here, we characterize the structure and function of vagal sensory neurons that express the angiotensin-II type 1a receptor (AT1aR) and provide evidence that these neurons are involved in blood pressure control. The implication is that AT1aR serve as a phenotypic marker for a subset of vagal baroreceptive neurons that may serve as a novel route to understand and alleviate hypertension.
Neural activity in anterior insula at drinking onset and licking relates to compulsion-like alcohol consumption
Authors: Starski Phillip , Morningstar Mitch D. , Katner Simon N. , Frasier Raizel M. , De Oliveira Sergio Thatiane , Wean Sarah , Lapish Christopher C. , Hopf F Woodward 
Published: January 2024

Much remains unknown about the etiology of compulsion-like alcohol drinking, where consumption persists despite adverse consequences. The role of anterior insula (AIC) in emotion, motivation, and interoception makes this brain region a likely candidate to drive challenge-resistant behavior, including compulsive drinking. Indeed, subcortical projections from AIC promote compulsion-like intake in rats, and are recruited in heavy-drinking humans during compulsion for alcohol, highlighting the importance of and need for more information about AIC activity patterns that support aversion-resistant responding. Single-unit activity was recorded in AIC from 15 male rats during alcohol-only and compulsion-like consumption. We found three sustained-firing phenotypes, sustained-increase, sustained-decrease, and drinking-onset cells, as well as several firing patterns synchronized with licking. While many AIC neurons had session-long activity changes, only neurons with firing increases at drinking onset had greater activity under compulsion-like conditions. Further, only cells with persistent firing increases maintained activity during pauses in licking, suggesting roles in maintaining drive for alcohol during breaks. AIC firing was not elevated during saccharin drinking, similar to lack of effect of AIC inhibition on sweet fluid intake in many studies. In addition, we observed subsecond changes in AIC neural activity tightly entrained to licking. One lick-synched firing pattern (determined for all licks in a session) predicted compulsion-like drinking, while a separate lick-associated pattern correlated with greater consumption across alcohol intake conditions. Collectively, these data provide a more integrated model for the role of AIC firing in compulsion-like drinking, with important relevance for how AIC promotes sustained motivated responding more generally.Significance StatementThe anterior insula cortex is known to drive many motivated behaviors, especially those involving challenge and emotion regulation, but insula activity patterns that promote and sustain such behaviors remain incompletely understood. Here we examined insula firing related to compulsion-like alcohol consumption, where intake persists despite adverse consequences. Compulsion can strongly contribute to alcohol problems, and also represents a useful test case for understanding how insula activity could sustain behavior in the face of challenge. Insula cells showed several session-long and lick-synched activity patterns. Compulsion-like drinking exhibited specific firing changes that led to the suggestion that insula helps evaluate the intake condition at drinking onset, then provides session-long plateau and lick-related activity to maintain responding despite challenge.
Rights of Low Vision Children and Their Parents
Authors: Hill J.L 
Published: January 2024

This paper will deal with the rights -medical, educational and rehabilitative -of a very special population of children. Children that are "at risk" because of their recognized visual impairment, as well as being "at risk" because some of their basic needs are not being met. Statistics for 1984 indicate that there are over 3,000 legally blind children under age 19 in Canada. Pratt sug­gested that there are four times as many partially sighted children as there are legally blind. If this is in fact true, there may be as many as 12,000 low vision children in Canada.
Innovación educativa: explorando el impacto del aula invertida en el rendimiento académico de estudiantes de secundaria en matemática
Authors: Rodríguez Jiménez Franmis José , Pérez Ochoa Maria Elena , Ulloa Guerra Óscar 
Published: January 2024

El aula invertida es un modelo pedagógico innovador que permite a estudiantes adquirir el conocimiento previo fuera del aula y luego en clase trabajar en actividades prácticas y colaborativas para aplicar y profundizar su aprendizaje. El objetivo del estudio fue evaluar el impacto del aula invertida sobre el rendimiento académico de estudiantes de nivel secundario en el área de matemática. Se realizó un estudio cuasiexperimental con un enfoque cuantitativo. La muestra incluyó 2 docentes y 134 estudiantes de tercer grado de secundaria del Liceo Ercilia Pepín de San Francisco de Macorís, República Dominicana, divididos en grupo experimental (invertido) y de control (tradicional). Se utilizó dos instrumentos: una guía de observación del proceso (cuaderno del investigador); y una prueba de conocimiento para el alumnado participante (examen), aplicada como pre-test y post-test. Además, se extrajo información importante desde las plataformas Classroom y Edpuzzle. Las calificaciones obtenidas desde las plataformas y a través de los exámenes, una vez analizados mediante pruebas estadísticas (t de Student), demostraron un impacto positivo del aula invertida en el rendimiento académico del estudiantado del grupo experimental (pre-test: M = 7.26, DE = 2.59; post-test: M = 9.12, DE = 2.87), frente al estudiantado de la clase tradicional (pre-test: M = 6.59, DE = 2.66; post-test: M = 7.22, DE = 2.77) a un nivel de significancia α = .05 y un IC de 95% (.857 - 2.940). Como conclusiones, existen diferencias estadísticamente significativas entre el rendimiento académico de estudiantes que recibieron clases de matemática mediante aula invertida y estudiantes que lo hicieron bajo una metodología tradicional. Como recomendación principal y línea futura de investigación, en virtud de la naturaleza evolutiva de las Tecnologías de la Información y la Comunicación (TIC) y su impacto en el proceso de enseñanza-aprendizaje, se sugiere a la comunidad científica que se lleven a cabo otros estudios longitudinales y comparativos para medir el progreso a lo largo del tiempo y, de esta forma, analizar cómo diferentes variables, como el acceso a la tecnología, la participación activa del alumnado y la retroalimentación constante, influyen en los resultados.
Systematic evaluation of Rutongshu oral liquid based on chromatographic fingerprinting and nontargeted metabolomic analysis
Authors: Fan Zheng , Xu Yuling , Lu Mengya , Yan Lanmeng , Du Fangping , Xu Jing , Tong Xiaohui , Han Rongchun 
Published: January 2024

AbstractBased on chromatographic fingerprinting combined with quantitative analysis on characteristic chemical constituents as well as hierarchical cluster analysis, an easy and sensitive approach utilizing high performance liquid chromatography (HPLC) was developed for the identification and quality evaluation of Rutongshu oral liquid (ROL). What is more, nontargeted metabolomic analysis was conducted to gain a global view in terms of its chemical profile. In this study, 16 peaks from different batches (S1–S10) of ROL samples produced by Taihe Hospital of Chinese Medicine were selected as common peaks for the evaluation of their similarity whose values of all tested 10 batches exceeded 0.90 when compared with the control fingerprints. Meanwhile, simultaneous quantification of five markers in the oral solution, including albiflorin, paeoniflorin, chlorogenic acid, quercetin and ferulic acid was performed, and standard curves established for respective reference substances showed good regression in the linear range (r2 > 0.999) with recoveries in the range of 98.96–102.35%. The ultra-high performance liquid chromatography (UHPLC) combined with Orbitrap Exploris 120 mass spectrometer resulted in 88 identified compounds. The results of validation showed that the established method was reproducible, precise and stable. This study offers an effective, dependable and useful approach for the systematic evaluation of the hospital formulation ROL.
Decentralization of Public Authorities in Ukraine: Administrative-legal, Environmental, Social and Customs Aspects
Authors: Hladii Oleksandr , Bondarchuk Oleksandr , Zhadan Yevgeny , Kucher Ihor , Samus Vadym 
Published: January 2024

The purpose of the research is to reveal the administrative-legal, environmental, social and customs principles of decentralization of public authority in Ukraine. Main content. The article reveals the main definitions of decentralization of power, analyzes advantages and disadvantages of the decentralization process in the public administration system. The article also presents the basic typology of decentralization of power in foreign countries and characterizes these types, as well as an attempt to summarize the reasons for performing decentralization in Ukraine. Methodology: The use of systemic, functional, and structural methods in this study made it possible to define concepts, types, as well as to establish the reasons for introduction of the decentralization reform in Ukraine. Conclusions. Various approaches to performing the reform in European countries and its results have been considered, which is due to the need to implement decentralization in Ukraine. The result of the work consists in determination of the main definitions of the decentralization of power, analysis of advantages and disadvantages of the decentralization process, definition of the main types of decentralization, as well as generalization of the main reasons for introduction of decentralization in Ukraine.
Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
Authors: Su Xiao-Tong , Reyes Jeremiah V. , Lackey Anne E. , Demirci Hasan , Bachmann Sebastian , Maeoka Yujiro , Cornelius Ryan J. , McCormick James A. , Yang Chao-Ling , Jung Hyun Jun , Welling Paul A. , Nelson Jonathan W. , Ellison David H. 
Published: January 2024

Significance Statement
High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but these subsegments serve distinctive functions, with more abundant magnesium-handling genes along DCT1 and more calcium-handling genes along DCT2. The data also provide insight into the plasticity of the distal nephron-collecting duct junction, formed from cells of separate embryonic origins. By focusing/changing gradients of gene expression, the DCT can morph into different physiological cell states on demand.

Background
The distal convoluted tubule (DCT) comprises two subsegments, DCT1 and DCT2, with different functional and molecular characteristics. The functional and molecular distinction between these segments, however, has been controversial.

Methods
To understand the heterogeneity within the DCT population with better clarity, we enriched for DCT nuclei by using a mouse line combining “Isolation of Nuclei Tagged in specific Cell Types” and sodium chloride cotransporter–driven inducible Cre recombinase. We sorted the fluorescently labeled DCT nuclei using Fluorescence-Activated Nucleus Sorting and performed single-nucleus transcriptomics.

Results
Among 25,183 DCT cells, 75% were from DCT1 and 25% were from DCT2. In addition, there was a small population (<1%) enriched in proliferation-related genes, such as Top2a, Cenpp, and Mki67. Although both DCT1 and DCT2 expressed sodium chloride cotransporter, magnesium transport genes were predominantly expressed along DCT1, whereas calcium, electrogenic sodium, and potassium transport genes were more abundant along DCT2. The transition between these two segments was gradual, with a transitional zone in which DCT1 and DCT2 cells were interspersed. The expression of the homeobox genes by DCT cells suggests that they develop along different trajectories.

Conclusions
Transcriptomic analysis of an enriched rare cell population using a genetically targeted approach clarifies the function and classification of distal cells. The DCT segment is short, can be separated into two subsegments that serve distinct functions, and is speculated to derive from different origins during development.
The Magnitude–Frequency Distributions of Earthquakes in Aotearoa New Zealand and on Adjoining Subduction Zones, Using a New Integrated Earthquake Catalog
Authors: Rollins Chris , Gerstenberger Matthew C. , Rhoades David A. , Rastin Sepideh J. , Christophersen Annemarie , Thingbaijam Kiran Kumar S. , Van Dissen Russell J. , Graham Kenny , DiCaprio Chris , Fraser Jeff 
Published: January 2024

ABSTRACT
Using a new integrated earthquake catalog for Aotearoa New Zealand (described in a companion article), we estimate the magnitude–frequency distributions (MFDs) of earthquakes in the greater New Zealand region and along the Hikurangi–Kermadec and Puysegur subduction zones. These are key inputs into the seismicity rate model (SRM) component of the 2022 New Zealand National Seismic Hazard Model. The MFDs are parameterized by a b-value (describing the relative rates of small and large earthquakes) with its epistemic uncertainty expressed by three logic tree branches (low, central, and high), and by the annual rate of M ≥ 5 earthquakes, here called the N-value, which has a separate value conditioned on each b-value branch. The N-value has its own epistemic uncertainty besides the dependence on the b-value, and this is also estimated here and propagated through the SRM by scaling all event rates up and down by a “low” and a “high” scalar value on either side of 1.0, called “N scaling.” Adapting an approach used previously in California, we estimate these MFD parameters in the onshore and near-shore region incorporating data back to 1843, balanced with the better data in the more recent part of the instrumental catalog. We estimate the MFD parameters on the Hikurangi–Kermadec and Puysegur subduction zones using a slightly simplified version of this approach and more recent data. We then use a globally-based method to estimate the potential earthquake rate uncertainty on the Hikurangi–Kermadec subduction zone and an SRM-specific moment-rate-related argument to construct an appropriately wide rate uncertainty for the Puysegur subduction zone.
Seismic Station Monitoring Using Deviation from the Gaussianity
Authors: Cuvier Arthur , Beucler Éric , Bonnin Mickaël , Garcia Raphaël F. 
Published: January 2024

AbstractDegradation of the seismic signal quality sometimes occurs at permanent and temporary stations. Although the most likely cause is a high level of humidity, leading to corrosion of the connectors, environmental changes can also alter recording conditions in different frequency ranges and not necessarily for all three components in the same way. Assuming that the continuous seismic signal can be described by a normal distribution, we present a new approach to quantify the seismogram quality and to point out any time sample that deviates from this Gaussian assumption. We introduce the notion of background Gaussian signal (BGS) to characterize a set of samples that follows a normal distribution. The discrete function obtained by sorting the samples in ascending order of amplitudes is compared with a modified Probit function to retrieve the elements composing the BGS, and its statistical properties (mostly its standard deviation σG). As soon as there is any amplitude perturbation, σG deviates from the standard deviation of all samples composing the time window (σ). Hence, the parameter log(σσG) directly quantifies the alteration level. For a single day, a given frequency range and a given component, the median of all log(σσG) that can be computed using short-time windows, reflects the overall gaussianity of the continuous seismic signal. We demonstrate that it can be used to efficiently monitor the quality of seismic traces using this approach at four broadband permanent stations. We show that the daily log(σσG) is sensitive to both subtle changes on one or two components as well as the signal signature of a sensor’s degradation. Finally, we suggest that log(σσG) and other parameters that are computed from the BGS bring useful information for station monitoring in addition to existing methods.
Publishing Educational and Educational-Methodical Literature in Siberia at the End of the 18th – 19th Centuries
Authors: Erlikh V. A. 
Published: January 2024

TThe purpose of the article is to form an idea of publishing educational and educational-methodical literature on disciplines taught in various educational institutions of Siberia at the end of the 18th– 19th centuries. Statistical information on publishing literature by year in the cities of the West Siberian and East Siberian educational districts is provided, the variety of topics of published works, the structure and content of a number of publications based on data from the volume 1 of the “Unified Catalog of Siberian and Far Eastern Books”. 1790–1917." (Novosibirsk, 2004) demonstrated. This article is the first attempt to present generalized data on statistics and topics of educational and educational-methodical publications issued inprinting houses of Siberia and the Far East at the end of the 18th–19th centuries. Such literature mostly prevailed in publishing in the West Siberian educational district, than in the East Siberian one. The bulk of publications were programs, reports of educational institutions and societies, charters, instructions, protocols, rules, regulations, works on the history of educational institutions, other works.The leaders in publishing such literature were Tomsk, Irkutsk, Tobolsk, with the largest number of printing houses involved.