bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of an immunogenic cell death related gene signature: A new prognostic model for small cell lung cancer
Authors: Liu Ming , Hou PanFei , Pan Yan , Jia ShuoSheng , Li HanWen , Sun Rong , Lin Jiang , Yang Xiaohong 
Published: December 2023

Abstract
Small cell lung cancer (SCLC) is a highly malignant cancer with poor prognosis. Therefore, more accurate models to identify high-risk patients are essential for facilitating personalized management of SCLC. Immunogenic cell death (ICD) is a process that stimulates robust anti-tumor immune responses and holds promising implications for cancer treatment. However, the expression of ICD-related genes in SCLC and their correlations with prognosis remain unclear. In this study, we employed a series of bioinformatic and machine learning approaches to establish an ICD-related risk score (ICDRS) and classified SCLC patients into low- or high-risk subgroups. Patients in the high-risk subgroup exhibited significantly lower survival probabilities, and the prognostic value of ICDRS was validated in independent cohorts. Furthermore, GSEA and tumor microenvironment (TME) analysis indicated that tumor proliferation and cancer-associated fibroblasts were enriched in the high-risk subgroup, while immune-realted scores were lower in high-risk subgroup. Overall, ICDRS could serve as a useful prognostic biomarker for overall survival (OS) in SCLC.
Analytical Solution for the Modeling Botanical Biofiltration of Indoor Air Quality
Authors: Jeeva N. , Dharmalingam K. M. , Veeramuni M. 
Published: December 2023

Abstract
In this paper, the mathematical model analyzed removing the VOCs using the biological-based treatment method of botanical biofiltration has been considered. We address the dimensionless mass balance concentration in the gas and biofilm phases for the indoor air quality model. Gas and biofilm phases described in a differential equations with boundary conditions. The dimensionless concentration of the gas and biofilm phases are solved analytically using new approaches analyzed methods such as Modified Adomian Decomposition Method (MADM). Furthermore, the analytical reports are then compared with the numerical findings for understanding the system behavior and to demonstrate the accuracy of the results.
Resonance perturbation of (5026) Martes and 20052 WW113 asteroid pair
Authors: Rosaev Alexey 
Published: December 2023

Abstract

The orbital dynamics of a very young asteroid pair (5026) Martes and 2005 WW113 is studied. We detect strong resonant perturbations of the larger member of the pair (5026) Martes by the 3:11 mean motion resonance with the Earth. The unbounded secondary (2005 WW113) has orbited far from the resonance and is not perturbed. We provide a new estimation of the resonance structure and found that, under the planetary perturbations, a single resonance splits into a multiplet. The nominal position of the resonance is 2.37783 AU. However, the center of the corresponding chaotic zone is detected at 2.37754 AU. As a result, we noted a small but not negligible difference between the calculated and observed position of resonance. The multiplet structure of the 3:11 Earth resonance cannot explain this offset (the position of the main term of the multiplet is 2.377698 AU).
Study protocol for The Family Empowerment Program: A Randomized Waitlist-Controlled Trial to Evaluate the Effectiveness of Online Community Reinforcement and Family Training (CRAFT) on the Wellbeing of Family Members with a Relative Experiencing Substance Dependence and Mental Illness
Authors: Allan Julaine , Snowdon Nicole , Thapa Subash , Ahmed Kedir 
Published: December 2023

Abstract

Background Systematic reviews consistently show that family-focused interventions are effective at improving substance treatment engagement and outcomes across the lifespan. Yet, Australian substance use treatment services rarely incorporate family members and concerned significant others. Testing of family focussed interventions in the Australian context is required. Methods The trial is a randomized wait-list control trial assessing the effectiveness, feasibility and acceptability of online CRAFT with a parallel group. Participants will be randomised to receive either online CRAFT or to a wait-list control group who are provided with CRAFT related reading material during the waiting period. Outcomes will be assessed at baseline and then at 6- and 15-weeks post baseline. The primary outcome will be improved wellbeing of participating family members. The trial reporting will comply with SPIRIT guidelines. Discussion This study will focus on people living in rural areas. Substance treatment programs are limited in rural Australia. The provision of the Family Empowerment Program (CRAFT) online should make family focused substance treatment support accessible and attainable for the first time in rural areas. The outcomes of this trial could have meaningful implications for the future funding and support of family focused substance treatment services that are inclusive of people with mental health conditions. Trial registration ANZCTR, ACTRN12623000796684p, Registered 26 July 2023. Prospectively registered with protocol version 3.
Fibroblast-based FN1CFD contributes to parathyroid cancer identification using integrated analysis
Authors: Shen Rongfang , Yang Wenjing , Liu Xing , Wang Jiacheng , Feng Dalin , Zhao Li , Wang Yuting , Huang Jian , Shen Hong , Wang Qian , Zhao Teng , Wei Bojun 
Published: December 2023

Abstract
Parathyroid cancer (PC) is a highly aggressive cancer with high relapse and metastasis rate. However, there still lack effective preoperative and intraoperative ways to discriminate between PC and parathyroid adenoma (PA). The intrinsic biological alternations that lead to PC still unclear. Here, we performed integrated analysis on the transcriptomic data of parathyroid tumors. To identify pivotal genes associated with PC diagnosis, we integrated the immune infiltration analysis, gene differential analysis and ROC analysis, and discovered that fibroblast expressed gene FN1 and CFD (FC score) was of great importance. The cancer diagnostic value of FC score was also validated in pan-cancer data covering the TCGA bulk tumor and single cell data. Cell communication and cancer hallmark correlation analysis showed that FC score was strongly associated with EMT process, which was the key step for tumor invasion and metastasis. Our results suggest the tumor fibroblast phenotype defined by FC score contributed to PC identification.
Enhanced Heat Transfer Performance in a Solar Air Heater using discrete V-Rib Geometry with Gap
Authors: Dubey Manoj Kumar , Prakash Om 
Published: December 2023

Abstract
Solar air heater (SAH) have emerged as promising technology for harnessing solar energy in a sustainable and environmentally friendly manner. Numerous techniques for enhancing heat transfer methods have been investigated to improve thermal performance. This study investigated how discrete V rib coarseness effect the performance of SAH. The experiments were conducted under different operating conditions, including rib pitch-to-height ratios (p/e) of 8, 10, and 12, an angle of inclination of 60 degrees, width to height of duct (W/H) 8, gap width to depth 4, Centre distance between two successive ribs of 0.5, number of gaps on each side of 1 and Reynolds number of 4000 to 145000. Experimental data indicated that the SAH equipped with the discrete V-rib geometry and gap achieved higher heat transfer rates compared to traditional SAH designs without this feature. In this case, the Nusselt number (Nu), Thermo-hydraulic performance parameters (THPP) and friction factor (f) increased by 3.62, 3.22, and 2.85, respectively, compared to a flat plate. These values indicate the improvements achieved by the artificial rib coarseness in enhancing heat transfer compared to a flat surface. Furthermore, study demonstrated that the new discrete V-rib geometry with a gap outperformed to existing designs.
Modified S-P approach and Ganz surgical dislocation for the treatment of Pipkin I-type fractures: a long-term retrospective study
Authors: Zhang Hanwen , Deng wei , Wang Shengtao , Yin yong 
Published: December 2023

Abstract

Background
Posterior hip dislocation is the commonest type of hip dislocation. As it frequently combined fractures and may cause complications. Urgent hip reduction is mandatory to improve clinical outcomes and avoid irreversible complications. The purpose of the present study is to compare the clinical efficacy of the modified Smith-Peterson (mS-P) and Ganz surgical dislocation (GSD) in treating Pipkin I fractures.
Methods
A retrospective analysis of 23 patients diagnosed with Pipkin I femoral head fracture was conducted in Pidu District People's Hospital from June 2010 to May 2020. Regarding the treatment classification, 11 cases were treated with mS-P approach and 12 cases were treated with GSD approach. 1 case in each group lost the follow-up period in this study. The follow-up time of the rest 21 patients was 12–55 months, with an average of 37.7 months. Functional evaluation was done using the Thompson-Epstein Score, Modifed Harris Hip Score(MHHS), and Vail Hip Score (VHS) at final follow-up. The incision length, intraoperative time, intraoperative blood loss, intraoperative blood transfusion, length of stay in hospital, fracture healing time, and postoperative complications were also examined and compared between the two groups.
Results
According to the Thompson-Epstein function evaluation system, 6 patients (60%) had excellent results, 3 patients (30%) were rated as good, 1 patients (10%) as fair, and the excellent and good rate was 90% in mS-P group. And 3 patients (27.2%) had excellent results, 5 patients (45.5%) were rated as good, 2 patients (18.2%) as fair, 1 patient (9%) as poor and the rate of Excellent and Good results was 72.7% in GSD group. According to Harris hip score, 4 patients (40%) were rated as excellent, 2 patients (20%) as good; 4 patients (50%) as fair in mS-P group. Among cases of GSD group, 1 patient (9%) was rated as Excellent, 2 patients (18.2%) as good, 7 patients (63.6%) as fair and 1 patient (9%) as poor. According to VSH score, the average score of mS-P group was 82.3, and 74.4 in GSD group.
Conclusions
Both the mS-P and GSD approach can achieve a satisfactory result in surgical treatment of Pipkin I fractures. Open reduction and internal fixation(ORIF) of Pipkin I fractures using mS-P approach is more visual and less invasive than GSD approach, as well as less amount of bleeding. However, mS-P approach cannot provide satisfactory results with low occurrence of postoperative complications.
Development of a Self-management program in Empowering People with Parkinson`s disease: a qualitative study using a co-creation framework
Authors: Thomsen Trine Hørmann , Skovbølling Sara , Møller Morten , Brønden Maria , Grønlund Vibeke , Ilsfort Dorthe , Frederiksen Jakob , Biering-Sørensen Bo 
Published: December 2023

Abstract
Background
Empowerment of People with Parkinson`s disease (PwP), involves providing the individuals with the knowledge, resources, and support they need to take an active role in managing their consequences of PD and making informed decisions about their treatment options.
Aim
Using a co-creation framework, this study aimed to develop a self-management intervention in collaboration with PwP, relatives and cross-sectoral health care professionals to empower the affected individuals and mitigate the consequences of the disease.
Method
This explorative study used a co-creation framework and content analysis to develop a self-management program. A workshop and two focus group interviews with PwP (n = 6), caregivers (n = 3) and health care professionals/other stakeholders (n = 10) informed the development process.
Results
A 8-week self-management program was developed providing 5 teaching sessions with specific themes, 1 home visit by a PD-nurse for action planning, goal setting and motivational interviewing, development of a personal goal-setting tool (“PD GOAL”), mindfulness-sessions, and objective monitoring of motor symptoms via the Parkinson KinetiGraph Watch (PKG At Home™) during the program.
Conclusion
This study provides knowledge about developing an individualized, 8-week self-management program tailored PwP using a co-creation framework. Further, in-depth knowledge about everyday life and specific needs when living with PD, were identified.
Determinant of aggressive phenotype in metastatic hormone sensitive prostate cancer depends on an intrinsic, highly aggressive cell cluster: Integrated single- cell and whole transcriptomic analyses
Authors: Jee ByulA , Yu Jiwoong , Hwang Soohyun , Park Kyunghee , Han Kyung Yeon , Chung Jae Hoon , Song Wan , Sung Hyun Hwan , Jeon Hwang Gyun , Jeong Byong Chang , Seo Seong Il , Jeon Seong Soo , Lee Hyun Moo , Park Woong-Yang , Kang Minyong 
Published: December 2023

Abstract

Several studies have reported that prostate cancer has a relatively favorable prognosis; however, patients with locally advanced and metastatic disease have significantly low 10-year survival rates. Although the combination of androgen deprivation therapy with docetaxel or abiraterone acetate and prednisone has become the standard treatment for metastatic hormone-sensitive prostate cancer (mHSPC), and improved overall survival, a subset of patients is prone to developing castration-resistant prostate cancer. Furthermore, the underlying mechanisms governing treatment response in these patients remain poorly understood. The objective of this study was to identify aggressive cell types in patients with mHSPCs with poor clinical outcomes. A comprehensive analysis of samples from patients with mHSPC was conducted and validated using a cohort of 52 patients with mHSPC. Our results identified a distinct subtype characterized by proliferative activation associated with unfavorable clinical outcomes. A novel 14-gene signature serving as a predictive marker for survival outcomes was developed to facilitate prognosis and guide treatment decisions, particularly in patients with mHSPC. This study provides valuable insights into the identification of high-risk patients, novel biomarkers, and potential therapeutic targets for individuals with mHSPC. Furthermore, the results in this study can serve as a basis for future investigations aimed at refining prognostic strategies and developing targeted therapies for patients with mHSPC.
Influence of Nano Magnesium oxide fillers on Tensile and Impact strength of Banana fibre reinforced epoxy composites
Authors: Raghavendra Subramanya , Raveendra R S , GN Anil Kumar 
Published: December 2023

Abstract

A novel polymer composite has been developed by incorporating both alkali-treated and untreated banana fibres into an epoxy resin matrix. Using a hand layup technique, composite laminates were created by adding nano magnesium oxides as filler material with varying loadings (0.5%, 1%, and 1.5% wt) to the epoxy matrix. To further understand the characteristics of Nano MgO, X-ray diffraction synthesis was examined. An investigation was conducted to examine the impact of Nano magnesium oxide on the tensile and hardness characteristics. The 1.5% weight Mgo reinforced laminates exhibited a significant enhancement in characteristics when compared to the untreated banana fibre laminates. This phenomenon can be attributed to the enhanced dispersion and contact between the banana fibres and the epoxy in the composites, which facilitates a more effective transfer of stress at the interface.
Soil acidification drives the negative effects of nitrogen enrichment on soil microbial biomass at the global scale
Authors: Li Shucheng , Tang Shiming , Ju Xiaotang , Zhu Zhihao , Zhang Yujuan , Chen Hongyang , Jin Ke 
Published: December 2023

Abstract
Background and aims
Nitrogen (N) deposition is a global driver of change that affects microbial biomass and ecosystem processes. However, it remains unclear whether N enrichment impacts microbial biomass in soil across ecosystems.
Methods
In this study, we synthesized 1,385 paired observations from 125 studies worldwide to evaluate the effects of N addition on soil microbial biomass.
Results
We found that N enrichment substantially suppresses total microbial biomass, including bacterial, fungal, and arbuscular mycorrhizal fungi biomass. Importantly, we found strong negative effects on microbial biomass globally caused by N-enrichment-induced soil acidification. Moreover, N enrichment mainly shapes the acidification of soil through the increased concentration of ammonium and by changing exchangeable cations in soil, including magnesium, calcium, sodium, manganese, and aluminum ions.
Conclusions
Overall, our findings demonstrate that N-enrichment-induced soil acidification is a crucial factor to consider for preserving microbial communities and ecosystem function under future trends of increasing N enrichment.
Investigating The Metric Basis And Metric Dimension Of Graphene
Authors: Abbas Wasim , Chaudhry Faryal , Afzal Deeba , Farooq Umar 
Published: December 2023

Abstract
This article explores the metric dimension of graphene, atwo-dimensional carbon allotrope, examining how a minimal set of carbon atoms can uniquely determine the distances between all atoms in thegraphene lattice. We investigate the implications of metric dimension for characterizing graphene’s structural features and discuss its potentialapplications in electronics, energy storage, and nanotechnology. Thea rticle aims to contribute to the understanding of graphene’s unique properties and its practical use in various fields
Optimizing soft skills acquisition through simulation training: balancing realism and academic stress in a longitudinal cohort study
Authors: Bukeyeva Aliya , Hendrixson Vaiva , Kemelova Gulshat , Aimbetova Dinara , Drobchenko Yelena , Riklefs Viktor 
Published: December 2023

Abstract

Background Teaching methods evolve to meet the expanding needs of students, emphasizing not only academic and technical skills but also essential soft skills. Simulation, particularly in virtual reality, plays a pivotal role, fostering technical proficiency and crucial interpersonal skills for healthcare professionals. However, the stress faced by students in simulated scenarios is a critical concern. To enhance the learning experience, our study explores stress levels induced by diverse educational technologies and clinical cases, aiming to provide recommendations for refining simulation training programs for medical students.Methods In longitudinal cohort study at Karaganda Medical University, 57 fifth-year general medicine students underwent a two-week emergency conditions simulation course. Employing 5 simulation techniques, including standardized patients, high-fidelity simulation and various virtual patients, students navigated through 5 challenging clinical scenarios. Learning outcomes were assessed through ongoing tutor assessments and a final OSCE. Stress levels were measured using self-reporting survey and heart rate variability analysis using wearable devices during training sessions. In total, 265 training sessions were ultimately recorded and analyzed using MANOVA and MANCOVA statistical analyses.Results The analysis revealed that educational technologies closely mirroring real situations induce higher psychophysiological stress. Notably, the text-based and screen simulators exhibited lower physiological stress levels than more realistic technologies like standardized patients, high-fidelity and immersive virtual patient simulations. Final OSCE scores were also notably higher for less stressful technologies. The study underscores the nuanced relationship between educational technologies, clinical cases, and learning outcomes, emphasizing the importance of tailored approaches for effective simulation training allowing students to get all required soft skills.Conclusion Restructuring the simulation program involves employing diverse technologies for complex cases and a single technology for simpler ones. Assessing students' psychophysiological states via questionnaires and debriefing is vital for comprehending the impact of educational technologies on effective simulation training.
Targeted therapy of breast cancer using PLAC1 antibody-drug conjugate
Authors: Mahmoudian Jafar , Ghods Roya , Jeddi-Tehrani Mahmood , Ghaffari-Tabrizi-Wizsy Nassim , Nejadmoghaddam Mohammad Reza , Ghahremanzadeh Ramin , Ostad Seyed Nasser , Zarnani Amir-Hassan 
Published: December 2023

Abstract
Background
Placenta-specific 1 (PLAC1) is one of the oncoplacental genes ectopically expressed in a wide variety of cancers. Antibody drug conjugates (ADC) have the potential to substantially improve efficacy and reduce toxicity of treatment compared with cytotoxic small-molecule drugs and are recently being employed for treatment of cancers. Here, efficacy of a SN38-conjugated monoclonal anti-PLAC1 antibody was examined in breast cancer.
Methods and Results
Anti-human PLAC1 monoclonal antibodies were produced and characterized. SN38 was conjugated to an anti-PLAC1 antibody (clone: 2H12C12) and conjugation efficacy was evaluated by UV spectrophotometry. Post-conjugation reactivity was then tested using ELISA and flow cytometry. In vitro cytotoxicity profiling of 2H12C12-SN38 was examined on MDA-MB-231 breast cancer cells using a flourimetric assay. The effect of 2H12C12-SN38 on MDA-MB-231 tumor growth and angiogenesis ex vivo was tested by chorioallantoic membrane (CAM) assay followed by immunohistochemical analysis of tumor. Pharmacokinetics of 2H12C12-SN38 in mice was measured by successive venipuncture after ADC administration. Inhibitory effects of anti-PLAC1 ADC on tumor growth was assessed in nude mice xenograft model of human breast cancer. Anti-PLAC1 ADC exerted a substantial cytotoxicity on MDA-MB-231 cells starting from a concentration of about 33 nM. ADC also significantly decreased the growth of MDA-MB-231 tumors on CAM assay but did not show a significant effect on tumor angiogenesis. Pharmacokinetics of anti-PLAC1 ADC in mice showed an average half-life (t1/2) of about 80 hours. Treatment of nude mice with ADC resulted in a significant decrease in tumor size compared to isotype-matched antibody-SN38 conjugate, unconjugated anti-PLAC1 antibody or free SN38.
Conclusion
This is the first therapeutic application of anti-PLAC1 ADC in a xenograft model of human breast cancer. Our results reinforce on embryonic origin of cancers and shed light on the potential therapeutic benefits of targeting oncofetal antigens in human breast cancer.
Oleuropein protects against 5-Fluorouracil-Induced nephrotoxicity and hepatotoxicity in Rats
Authors: Banaei Shokofeh , Asghariazar Vahid , Mahdizadeh Faraz , Chinifroush-Asl Mir-Mehdi , Safarzadeh Elham 
Published: December 2023

Abstract

Purpose The renal and liver dysfunction is considered to be a life-threatening side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the effects of Oleuropein (OLE) against 5-FU-induced renal and liver toxicity. Methods Twenty-four adult Sprague-Dawley rats were randomly divided into 4 groups (N = 6) including the control, 5-FU (100 mg/kg), OLE (200 mg/kg), 5-FU + OLE. After treatment, blood sample were collected for the measurement of biochemical parameters, and the kidney and liver tissues were removed for the determination of inflammatory markers and histological changes. Results 5-FU significantly increased blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), liver enzyme levels, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) concentration. Also, histopathological findings of 5-FU showed acute tubular necrosis (ATN) in the renal tissues and coagulative necrosis in the hepatocytes. While the administration of OLE significantly decreased BUN-Cr, liver enzyme levels and inflammation and improved pathological changes. Conclusion Oleuropein exerted hepato-nephroprotective effects against 5-fluorouracil toxicity by the reduction of inflammatory factors.