bluuebunny/crossref_metadata_2025_split huggingface dataset:
What do parents think about the quality and safety of care provided by hospitals to children and young people with an intellectual disability? A qualitative study using thematic analysis
Authors: Ong Natalie , Lucien Abbie , Long Janet , Weise Janelle , Burgess Annette , Walton Merrilyn 
Published: November 2023

AbstractObjectivesChildren with intellectual disability experience patient safety issues resulting in poor care experiences and health outcomes. This study sought to identify patient safety issues that pertain to children aged 0–16 years with intellectual disability admitted to two tertiary state‐wide children's hospitals and a children's palliative care centre; to describe and understand these factors to modify the Australian Patient Safety Education Framework to meet the particular needs for children and young people with intellectual disability.Design, Setting and ParticipantsParents of children with intellectual disability from two paediatric hospitals and a palliative care unit participated in semi‐structured interviews to elicit their experiences of their child's care in the context of patient safety. Thirteen interviews were conducted with parents from various backgrounds with children with intellectual, developmental and medical diagnoses.ResultsEight themes about safety in hospital care for children and young people with intellectual disability emerged from thematic analyses: Safety is not only being safe but feeling safe; Negative dismissive attitudes compromise safety, quality and care experience; Parental roles as safety advocates involve being heard, included and empowered; Need for purposeful and planned communication and care coordination to build trust and improve care; Systems, processes and environments require adjustments to prevent patient safety events; Inequity in care due to lack of resources and skills, Need for training in disability‐specific safety and quality issues and Core staff attributes: Kindness, Patience, Flexibility and Responsiveness. Parents highlighted the dilemma of being dismissed when raising concerns with staff and being required to provide care with little support. Parents also reported a lack of comprehensive care coordination services. They noted limitations within the healthcare system in accommodating reasonable adjustments for a family and child‐centred context.ConclusionsThe development of an adapted Patient Safety Education Framework for children with intellectual disability should consider ways for staff to transform attitudes and reduce bias which leads to adaptations for safer and better care. In addition, issues that apply to quality and safety for these children can be generalised to all children in the hospital.Patient and Public ContributionParent advocates in the project advisory team were shown the questions to determine their appropriateness for the interviews.
Development and validation of search filters to retrieve medication discontinuation articles in Medline and Embase
Authors: Morel Thomas , Nguyen‐Soenen Jérôme , Thompson Wade , Fournier Jean‐Pascal 
Published: November 2023

AbstractBackgroundMedication discontinuation studies explore the outcomes of stopping a medication compared to continuing it. Comprehensively identifying medication discontinuation articles in bibliographic databases remains challenging due to variability in terminology.ObjectivesTo develop and validate search filters to retrieve medication discontinuation articles in Medline and Embase.MethodsWe identified medication discontinuation articles in a convenience sample of systematic reviews. We used primary articles to create two reference sets for Medline and Embase, respectively. The reference sets were equally divided by randomization in development sets and validation sets. Terms relevant for discontinuation were identified by term frequency analysis in development sets and combined to develop two search filters that maximized relative recalls. The filters were validated against validation sets. Relative recalls were calculated with their 95% confidences intervals (95% CI).ResultsWe included 316 articles for Medline and 407 articles for Embase, from 15 systematic reviews. The Medline optimized search filter combined 7 terms. The Embase optimized search filter combined 8 terms. The relative recalls were respectively 92% (95% CI: 87–96) and 91% (95% CI: 86–94).ConclusionsWe developed two search filters for retrieving medication discontinuation articles in Medline and Embase. Further research is needed to estimate precision and specificity of the filters.
Large cribriform glands (> 0.25 mm diameter) as a predictor of adverse pathology in men with Grade Group 2 prostate cancer
Authors: Greenland Nancy Y , Cowan Janet E , Stohr Bradley A , Simko Jeffry P , Carroll Peter R , Chan Emily 
Published: November 2023

AimsA recent outcome‐based, radical prostatectomy study defined > 0.25 mm diameter to distinguish large versus small cribriform glands, with > 0.25 mm associated with worse recurrence‐free survival. This study evaluates whether identification of > 0.25 mm cribriform glands in Grade Group 2 patients at biopsy is associated with adverse pathology at radical prostatectomy.Methods and resultsTumours containing biopsy slides for 133 patients with Grade Group 2 prostate cancer with subsequent radical prostatectomy were re‐reviewed for large cribriform glands (diameter > 0.25 mm). The primary outcome was adverse pathology (Grade Groups 3–5; stage pT3a or greater, or pN1). The secondary outcome was recurrence‐free survival. Cribriform pattern was present in 52 of 133 (39%) patients; of these, 16 of 52 (31%) had large cribriform glands and 36 of 52 (69%) had only small cribriform glands. Patients with large cribriform glands had significantly more adverse pathology at radical prostatectomy compared to patients with small cribriform glands and no cribriform glands (large = 11 of 16, 69%; small = 12 of 36, 33%; no cribriform = 25 of 81, 31%; χ2 P‐value 0.01). On multivariate analysis, large cribriform glands were also associated with adverse pathology, independent of age, prostate‐specific antigen (PSA)/PSA density at diagnosis, year of diagnosis and biopsy cores percentage positive (global P‐value 0.02). Large cribriform glands were also associated with increased CAPRA‐S surgical risk score (Kruskal–Wallis P‐value 0.02).ConclusionsLarge cribriform glands using a diameter > 0.25 mm definition in Grade Group 2 patients on biopsy are associated with increased risk of adverse pathology at radical prostatectomy. The presence of large cribriform histology should be considered when offering active surveillance for those with Grade Group 2 disease.
Honey therapies for dermatological disorders: more than just a sweet elixir
Authors: Jodidio Maya , Schwartz Robert A. 
Published: November 2023

AbstractHoney possesses antibacterial, anti‐inflammatory, and healing properties that benefit wound healing and tissue regeneration. For centuries, honey has been utilized in traditional medicine as a binder or vehicle for creams and lotions and also for therapeutic purposes. The overuse of antibiotics and antimicrobial agents leading to drug resistance has emphasized the resurgence of honey's application in wound care. For many dermatological disorders, there is an interest in developing therapeutics with fewer side effects than traditional therapies and enhanced wound healing abilities to expedite tissue regeneration. This paper reviews the properties and components of honey that contribute to its wound‐healing‐based applications, the types of honey employed in medicine, and its dermatological applications. Based on the evidence from case reports, clinical trials, andin vitrostudies, honey has been characterized as a safe, cost‐effective, and readily available treatment option for many skin conditions, including microbial infections, atopic dermatitis, psoriasis, necrotizing fasciitis, ulcers, as well as thermal and other types of wounds.
Differences in overall survival of penile cancer patients versus population‐based controls
Authors: Scheipner Lukas , Tappero Stefano , Piccinelli Mattia Luca , Barletta Francesco , Garcia Cristina Cano , Incesu Reha‐Baris , Morra Simone , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Terrone Carlo , De Cobelli Ottavio , Briganti Alberto , Chun Felix K. H. , Tilki Derya , Longo Nicola , Seles Maximilian , Ahyai Sascha , Karakiewicz Pierre I. 
Published: November 2023

PurposeTo assess whether 5‐year overall survival (OS) of squamous cell carcinoma of the penis (SCCP) patients differs from age‐matched male population‐based controls.MethodsWe relied on the Surveillance Epidemiology and End Results database (2004–2018) to identify newly diagnosed (2004–2013) SCCP patients. For each case, we simulated an age‐matched control (Monte Carlo simulation), relying on the Social Security Administration (SSA) Life Tables with 5 years of follow‐up. We compared OS between SCCP patients and population‐based controls in a stage‐specific fashion. Smoothed cumulative incidence plots displayed cancer‐specific mortality (CSM) versus other‐cause mortality (OCM).ResultsOf 2282 SCCP patients, the stage distribution was as follows: stage I 976 (43%) versus stage II 826 (36%) versus stage III 302 (13%) versus stage IV 178 (8%). At 5 years, OS of SCCP patients versus age‐matched population‐based controls was as follows: stage I 63% versus 80% (Δ = 17%), stage II 50% versus 80% (Δ = 30%), stage III 39% versus 84% (Δ = 45%), stage IV 26% versus 87% (Δ = 61%). At 5 years, CSM versus OCM in SCCP patients according to stage was as follows: stage I 12% versus 24%, stage II 22% versus 28%, stage III 47% versus 14%, and stage IV 60% versus 14%.ConclusionSCCP patients exhibit worse OS across all stages. The difference in OS at 5 years between SCCP and age‐matched male population‐based controls ranged from 17% to 61%. At 5 years, CSM accounted for 12% to 60% of all deaths, across all stages.
Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity
Authors: Xia Pengpeng , Ji Xingduo , Yan Li , Lian Siqi , Chen Ziyue , Luo Yi 
Published: November 2023

AbstractS100 proteins are small proteins that are only expressed in vertebrates. They are widely expressed in many different cell types and are involved in the regulation of calcium homeostasis, glucose metabolism, cell proliferation, apoptosis, inflammation and tumorigenesis. As members of the S100 protein subfamily of myeloid‐related proteins, S100A8, S100A9 and S100A12 play a crucial role in resisting microbial infection and maintaining immune homeostasis. These proteins chelate the necessary metal nutrients of pathogens invading the host by means of ‘nutritional immunity’ and directly inhibit the growth of pathogens in the host. They interact with receptors on the cell surface to initiate inflammatory signal transduction, induce cytokine expression and participate in the inflammatory response and immune regulation. Furthermore, the increased content of these proteins during the pathological process makes them useful as disease markers for screening and detecting related diseases. This article summarizes the structure and function of the proteins S100A8, S100A9 and S100A12 and lays the foundation for further understanding their roles in infection, immunity and inflammation, as well as their potential applications in the prevention and treatment of infectious diseases.
Comprehensive analysis of risk factors for surgical site infections following thoracoscopic radical resection in patients with lung cancer
Authors: Tao Tao , Li Qicai , Yang Yifan , Wang Guowen 
Published: November 2023

AbstractSurgical site infections (SSIs) post‐thoracoscopic radical resection in lung cancer patients pose significant clinical challenges. This study aims to comprehensively identify the independent risk factors that influence the occurrence of SSIs following thoracoscopic radical resection for lung cancer. The study employed a retrospective analysis of 130 patients who underwent thoracoscopic radical resection for lung cancer. Inclusion and exclusion criteria were clearly defined, and ethical approvals were obtained. Patients were monitored for SSIs via clinical and biochemical markers, with data comprehensively gathered from electronic health records. Statistical analysis was rigorously conducted using SPSS v27.0, with methodologies including t‐tests, Chi‐square tests and logistic regression. The study aimed to identify independent risk factors for SSIs and incorporated a multidimensional assessment approach to provide robust, clinically relevant findings. Univariate analysis revealed surgical duration ≥3 h, non‐usage of antibiotics, presence of diabetes and elevated levels of C‐reactive protein (CRP) and procalcitonin (PCT) as significant correlates for SSIs. Multivariate analysis substantiated these factors as independent risk variables: surgery duration (odds ratio [OR] = 9.698, p < 0.05), presence of diabetes (OR = 6.89, p < 0.05), elevated CRP (OR = 7.306, p < 0.05) and elevated PCT (OR = 6.838, p < 0.05). Conversely, antibiotic administration served as a protective factor (OR = 0.572, p < 0.05). Surgical duration of 3 h or more, diabetes and elevated levels of CRP and PCT significantly heighten the risk for SSIs after thoracoscopic radical resection in lung cancer patients. Perioperative antibiotic administration acts as a protective factor. Clinicians should implement tailored preventative strategies to mitigate these identified risks.
Nurses' perspectives on challenges and facilitators when implementing a self‐management support intervention as an everyday healthcare practice: A qualitative study
Authors: Fredens Mia , Palmhøj Nielsen Camilla , Grønkjær Mette , Kjærside Nielsen Berit , Konstantin Nissen Nina , Benthien Kirstine Skov , Toft Ulla , Rasmussen Knud , Kidholm Kristian , Deleuran Terkildsen Morten 
Published: November 2023

AbstractAimTo explore registered nurses' perspectives on challenges and facilitators to implementing a telephone‐based self‐management support (SMS) intervention (Proactive Health Support) as an everyday healthcare practice, during the early stages of implementation.DesignData were collected using a qualitative research design involving focus‐group interviews and participant observations.MethodsWe conducted participant observation following nine nurses and four focus group interviews with 14 nurses. Data were analysed using thematic analyses.ResultsProactive Health Support was implemented in units organized independently of the existing organizational units within healthcare services. This independent organization, along with the intervention's generic (non‐disease specific) design, empowered nurses to become autonomous practitioners capable of prioritizing the operationalization of SMS as an everyday healthcare practice. However, unlearning already embedded medical practices and establishing new nursing roles necessary to accommodate the intervention in practice was experienced a challenge. Education and supervision were identified as valuable tools for successful implementation.ConclusionOur study highlights the significance of organizational context and autonomy in successful SMS implementation. Balancing external factors like organizational context, priority and time is vital, but navigating the internal shift in professional practice is equally crucial. Role transition processes can constitute challenges demanding accommodation.Implications for the ProfessionFrom a nursing perspective, this study highlights that practising SMS requires substantial training and education. Generic SMS interventions can introduce higher levels of contingency due to their versatile nature. Thus, equipping nurses with competencies that enable them to navigate this unpredictability flexibly is crucial.ImpactPolicymakers and administrators should allocate resources and support implementation processes in ways that accommodate both internal and external conditions to facilitate nurses in delivering effective SMS.Reporting MethodThis study adheres to the SRQR guideline.Patient or Public ContributionNo patient or public contribution.
Exploring home births in Catalonia (Spain): A cross‐sectional study of women's experiences and influencing factors
Authors: Alcaraz‐Vidal Lucia , Leon‐Larios Fatima , Robleda Gemma , Vila‐ Candel Rafael 
Published: November 2023

AbstractAimThe study explores the experiences of women with low‐risk pregnancies and no complications who planned a home birth.DesignA cross‐sectional study was conducted using an online questionnaire.MethodsThe questionnaire included socio‐demographic, obstetric and perinatal variables. Birth satisfaction was evaluated via the Spanish version of the childbirth experience questionnaire. The study group comprised home‐birthing women in Catalonia, Spain. Data were collected from 1 January 2019 to 31 December 2021. Statistical analysis was performed using SPSS.ResultsA total of 236 women responded. They reported generally positive experiences, with professional support and involvement being the most highly rated dimensions. Better childbirth experiences were associated with labour lasting less than 12 h, no perineal injuries, no intrapartum transfers to hospital, euthocic delivery and the presence of a midwife.ConclusionsWomen's positive home birth experiences were linked to active participation and midwife support. Multiparous women felt safer. Medical interventions, especially transfers to hospitals, reduced satisfaction, highlighting the need for improved care during home births.Implications for the Profession and Patient CareHome births should be included among the birthplace options offered by public health services, given the extremely positive feedback reported by women who gave birth at home.ImpactHome birth is not an option offered under Catalonia's public health system only as a private service. The experience of home‐birthing women is unknown. This study shows a very positive birth experience due to greater participation and midwife support. The results help stakeholders assess home birth's public health inclusion and understand valued factors, supporting home‐birthing women.Reporting MethodThe study followed the STROBE checklist guidelines for cross‐sectional studies.Public ContributionWomen who planned a home birth participated in the pilot test to validate the instrument, and their contributions were collected by the lead researcher. The questionnaire gathered the participants' email addresses, and a commitment was made to disseminate the study's results through this means.
Health and social care managers' perceptions of factors affecting the competence of managers in knowledge management: A qualitative study
Authors: Karsikas Eevi , Koivunen Kirsi , Meriläinen Merja , Kanste Outi 
Published: November 2023

AbstractAimTo describe health and social care managers' perceptions of the factors affecting the competence of managers in knowledge management.DesignA qualitative descriptive study.MethodsA semi‐structured interview was conducted with 15 managers from three public health and social care organizations in Finland. Data were collected in the spring of 2022 and analysed using inductive content analysis.ResultsHealth and social care managers perceived that the competence of managers working in knowledge management is affected by managers' behavioural and attitudinal characteristics, their interactive network competence in knowledge management, the dimensions of their competence in knowledge management, the knowledge management infrastructure with which they work and the organizational learning culture within which they work.ConclusionsThe competence of health and social managers in knowledge management is influenced by various factors, including their personal characteristics, management competence and the infrastructure and culture of the organization for which they work. However, their competence is constrained by an absence of clear processes, structures and resources in knowledge management as well as a lack of systematic support and training for managers working in knowledge management.ImpactThe study provides valuable information for improving the competence of managers working in knowledge management in health and social care organizations. The competence of managers working in knowledge management is instrumental for successful implementation and sustaining of knowledge management practices and thus, such competence has a positive impact on the overall performance of an organization.ImplicationsClarifying the roles and responsibilities of health and social care managers, as well as establishing organizational structures, is essential for effective knowledge management in organizations.Reporting MethodConsolidated Criteria for Reporting Qualitative Research (COREQ) checklist has been used in the reporting.Patient or Public ContributionNo patient or public contribution.
A biogeographic–macroecological perspective on the rising novelty of the biosphere in the Anthropocene
Authors: Kerr Matthew R. , Ordonez Alejandro , Riede Felix , Svenning Jens‐Christian 
Published: November 2023

AbstractThe concept of novel ecosystems has been discussed for over more than a decade to describe ecosystems that have an altered species composition and function, such that the community has crossed a threshold forbidding a return to its historical state. While spatial and temporal community compositional change has been well studied in biogeography, studies on novel ecosystems in a modern context are few and tend towards classifying novelty based on a static baseline. Given that the abiotic and biotic drivers of novelty are in a state of rapid change, and reaching levels unprecedented within the last hundred thousand to million years, defining such a threshold requires additional thought. Here, we discuss a biogeographical–macroecological perspective on novel ecosystems, exploring how such a threshold for novelty can be defined in an environment undergoing progressive global change and suggesting pathways through which the emergence and spread of novelty can be further explored, understood and managed.
Embodied preparation for learning basic quantum chemistry: A mixed‐method study
Authors: Müller Charlotte H. , Reiher Markus , Kapur Manu 
Published: November 2023

AbstractBackgroundHaptic feedback has been shown to be an effective facilitator of the learning of scientific concepts in a series of studies. However, little is known about the underlying salient learning mechanisms, which are activated when learning from haptic feedback.ObjectivesWe investigate the learning mechanism in a higher chemistry education setting, in which the students learned about the abstract concept of potential energy in a quantum chemical context.MethodsIn this work, we present a mixed‐methods problem‐solving prior to instruction (PS‐I) study with chemistry bachelor students. In an interactive quantum chemistry learning environment, the students explored the energetic profiles of nucleophilic substitution reactions and the corresponding activation barriers experienced as repulsion and attraction. We measured cognitive and affective mechanisms which have been shown to be activated in PS‐I designs, such as knowledge gap awareness, state curiosity, and positive affect as well as the learning outcome quantitatively and the learning trajectories qualitatively.Results and ConclusionsPlanned contrasts revealed a small hindering effect of the haptic feedback on the learning outcome. Thematic analysis of the qualitative data lets us attribute this effect to the lack of scaffolding of the haptic feedback and the spontaneous atomic movements in the simulation, which may be interpreted as a visual representation of force in itself.This work highlights the importance of accurate mappings of the haptic feedback unto the target domain and further delivers insight into the prior conceptions of chemistry undergraduate students.