bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pair programming with ChatGPT for sampling and estimation of copulas
Authors: Górecki Jan 
Published: December 2023

AbstractWithout writing a single line of code by a human, an example Monte Carlo simulation-based application for stochastic dependence modeling with copulas is developed through pair programming involving a human partner and a large language model (LLM) fine-tuned for conversations. This process encompasses interacting with ChatGPT using both natural language and mathematical formalism. Under the careful supervision of a human expert, this interaction facilitated the creation of functioning code in MATLAB, Python, and . The code performs a variety of tasks including sampling from a given copula model, evaluating the model’s density, conducting maximum likelihood estimation, optimizing for parallel computing on CPUs and GPUs, and visualizing the computed results. In contrast to other emerging studies that assess the accuracy of LLMs like ChatGPT on tasks from a selected area, this work rather investigates ways how to achieve a successful solution of a standard statistical task in a collaboration of a human expert and artificial intelligence (AI). Particularly, through careful prompt engineering, we separate successful solutions generated by ChatGPT from unsuccessful ones, resulting in a comprehensive list of related pros and cons. It is demonstrated that if the typical pitfalls are avoided, we can substantially benefit from collaborating with an AI partner. For example, we show that if ChatGPT is not able to provide a correct solution due to a lack of or incorrect knowledge, the human-expert can feed it with the correct knowledge, e.g., in the form of mathematical theorems and formulas, and make it to apply the gained knowledge in order to provide a correct solution. Such ability presents an attractive opportunity to achieve a programmed solution even for users with rather limited knowledge of programming techniques.
Non-retroviral Endogenous Viral Elements in Tephritid Fruit Flies Reveal Former Viral Infections Not Related to Known Circulating Viruses
Authors: Hernández-Pelegrín Luis , Ros Vera I. D. , Herrero Salvador , Crava Cristina M. 
Published: December 2023

AbstractA wide variety of insect-specific non-retroviral RNA viruses specifically infect insects. During viral infection, fragments of viral sequences can integrate into the host genomes creating non-retroviral endogenous viral elements (nrEVEs). Although the exact function of nrEVEs is so far unknown, some studies suggest that nrEVEs may interfere with virus replication by producing PIWI-interacting RNAs (piRNAs) that recognize and degrade viral RNAs through sequence complementarity. In this article, we identified the nrEVEs repertoire of ten species within the dipteran family Tephritidae (true fruit flies), which are considered a major threat to agriculture worldwide. Our results suggest that each of these species contains nrEVEs, although in limited numbers, and that nrEVE integration may have occurred both before and after speciation. Furthermore, the majority of nrEVEs originated from viruses with negative single-stranded RNA genomes and represent structural viral functions. Notably, these nrEVEs exhibit low similarity to currently known circulating viruses. To explore the potential role of nrEVEs, we investigated their transcription pattern and the production of piRNAs in different tissues of Ceratitis capitata. We successfully identified piRNAs that are complementary to the sequence of one nrEVE in C. capitata, thereby highlighting a potential link between nrEVEs and the piRNA pathway. Overall, our results provide valuable insights into the comparative landscape of nrEVEs in true fruit flies, contributing to the understanding of the intimate relation between fruit flies and their past and present viral pathogens.
Analysis of the ocular surface functional unit in episodic migraine
Authors: Patzkó Ágnes , Csutak Adrienne , Tóth Noémi , Kölkedi Zsófia , Pfund Zoltán , Kis-Jakab Gréta , Bosnyák Edit , Rozgonyi Renáta , Szalai Eszter 
Published: December 2023

Abstract
Aim
Migraine is a chronic neurovascular disease that affects the trigeminovascular system. The purpose of this study was to evaluate corneal subbasal nerve fibers, dendritic cells and to measure tear film parameters in migraine.

Patients and methods
87 eyes of 44 patients suffering from migraine with a mean age of 33.23 ± 11.41 years were included in our study. 25 age-matched controls (mean age of 30.16 ± 12.59 years; P = 0.162) were recruited. The corneal subbasal plexus and the dendritic cells (DC) were analyzed using in vivo confocal microscopy (Heidelberg Retina Tomograph II Rostock Cornea Module; Heidelberg Engineering GmbH), and the tear film was imaged using LacryDiag (Quantel Medical, France).

Results
Regarding the subbasal nerve fibers of the cornea, none of the examined parameters differed significantly in migraine patients from controls. We found a significant increase in the corneal DC density (P < 0.0001) and DC area (P < 0.0001) in migraine patients compared to healthy volunteers. DC density showed a positive correlation with the monthly attack frequency (r = 0.32, P = 0.041) and the DC area a negative correlation with corneal nerve branch density (r = -0.233, P = 0.039), nerve fiber length (r = -0.232, P = 0.04) and total branch density (r = -0.233, P = 0.039). Using LacryDiag a significant loss of Meibomian gland area could be detected on the superior eyelid (P = 0.005) in migraine.

Conclusions
Our results suggest the presence of neuroinflammation in the cornea of migraine patients affecting the peripheral trigeminal system. Dendritic cells surrounding the subbasal plexus may be involved in the activation and modulation of pain in migraine.
Insights into the rapid metabolism of Geobacillus sp. LC300: unraveling metabolic requirements and optimal growth conditions
Authors: Ljungqvist Emil , Daga-Quisbert Jeanett , van Maris Antonius , Gustavsson Martin 
Published: December 2023

AbstractThis study investigated the metabolism of Geobacillus sp. LC300, a promising biorefinery host organism with high substrate utilization rates. A new defined medium was designed and tested that allows for exponential growth to elevated cell densities suitable for quantitative physiological studies. Screening of the metabolic requirements of G. sp. LC300 revealed prototrophy for all essential amino acids and most vitamins and only showed auxotrophy for vitamin B12 and biotin. The effect of temperature and pH on growth rate was investigated, adjusting the optimal growth temperature to several degrees lower than previously reported. Lastly, studies on carbon source utilization revealed a capability for fast growth on several common carbon sources, including monosaccharides, oligosaccharides, and polysaccharides, and the highest ever reported growth rate in defined medium on glucose (2.20 h−1) or glycerol (1.95 h−1). These findings provide a foundation for further exploration of G. sp. LC300's physiology and metabolic regulation, and its potential use in bioproduction processes.
Clinical and molecular characteristics of Klebsiella pneumoniae infection in a tertiary general hospital of Wuhan, China
Authors: Xiang Yating , Tian Hongpan , Chen Qingsong , Gu Jihong , Liu Hongmao , Wang Cuixiang , Li Yirong 
Published: December 2023

Abstract
Objectives
The aim of this study was to investigate the clinical and molecular characteristics of Klebsiella pneumoniae infection from a tertiary general hospital in Wuhan, China.

Methods
From December 2019 to August 2022, 311 non-duplicate isolates of K. pneumoniae were collected from a tertiary hospital in Wuhan. These comprised 140 carbapenem-resistant K. pneumoniae (CRKP) isolates and 171 carbapenem-susceptible K. pneumoniae (CSKP) isolates. The clinical characteristics of patients with K. pneumoniae infection were retrospectively collected. Polymerase chain reaction (PCR) assays were used to identify the main carbapenem resistance genes, virulence genes and multi-locus sequence typing (MLST) profiles of the isolates, and the Galleria mellonella infection model was used to determine their virulence phenotypes.

Results
Independent risk factors for CRKP infection were hypertension, neurological disorders, being admitted to the intensive care unit (ICU) and prior use of antibiotics. Patient with CRKP infection had higher mortality than those with CSKP infection (23.6% vs 14.0%, P < 0.05). One hundred and two sequence types (STs) were identified among the K. pneumoniae isolates, and the most prevalent ST type was ST11 (112/311, 36.0%). All of the ST11 isolates were CRKP. Among the 112 ST11 isolates, 105 (93.8%) harboured the carbapenem resistance gene blaKPC-2 (ST11-KPC-2), and of these isolates, 78 (74.3%, 78/105) contained all of the four virulence genes, namely rmpA, rmpA2, iroN and iucA, suggesting that these genes were widespread among the isolates responsible for K. pneumoniae infections.

Conclusion
In this study, ST11-KPC-2 was responsible for most of the K. pneumoniae infection cases. Carbapenem resistance rather than the co-occurrence of the virulence genes rmpA, rmpA2, iroN and iucA was associated with K. pneumoniae infection-related mortality during hospitalisation. Furthermore, a high proportion of ST11-KPC-2 isolates carried all of the four virulence genes.
Bridging group work and whole-class activities through responsive teaching in science education
Authors: Silseth Kenneth , Furberg Anniken 
Published: December 2023

AbstractPrevious studies have shown both benefits and challenges of group work and whole-class activities in educational settings. One overall finding in the existing literature is that it is challenging for teachers to facilitate whole-class conversations that realise the rich potential of student discussions and undertakings during group work. This article investigates how teachers can facilitate productive consolidating whole-class conversations building on students’ group work experiences by enacting responsive teaching practices, implying foregrounding students’ experiences and ideas, and pursuing the substance of the students’ experiences and ideas in instructional work. Based on a sociocultural perspective, we analyse sequences of classroom interactions where students’ experiences from their lifeworld are invoked in a) settings where student engage in small group activities and b) teacher facilitated whole-class conversations. The educational context is a science project about genetics involving lower secondary school students and their science teacher. Our analysis shows that in group work settings, students’ everyday experiences are invoked but are seldom picked up on and pursued in group conversations as resources for engaging with science matters. In whole-class conversations facilitated by the teacher, especially in situations in which the teacher assumed a responsive teaching approach, students’ everyday experiences were more often realised as resources for shared meaning making and engagement with scientific concepts and ideas. We discuss this study’s implications for teachers designing productive learning activities that combine group work and whole-class activities.
Natural nest cavities in a high elevation habitat provide a more constant thermal environment than human-made nest cavities
Authors: Niffenegger Carole A. , Dirren Sebastian , Schano Christian , Korner-Nievergelt Fränzi 
Published: December 2023

AbstractNest cavities with suitable thermal conditions can provide fitness benefits for birds through reduced thermoregulatory cost. Insulation can however vary between natural and human-made cavities. While several studies have assessed cavity temperatures, research from high elevation habitats, where environmental conditions are particularly variable, is still scarce. We compared temperature profiles of vacant natural and human-made nest cavities of White-winged snowfinches Montifringilla nivalis, a high elevation cavity nestling species. Human-made cavities experienced more extreme temperatures, with potential consequences for offspring viability, bringing into question their suitability as conservation measure, particularly as extreme temperature events become more frequent.
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Authors: Su Fengting , Koeberle Andreas 
Published: December 2023

AbstractHepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic reprogramming. De novo lipogenesis is under the control of the transcription factor sterol regulatory element-binding protein 1 (SREBP-1) and essentially contributes to HCC progression. Here, we summarize the current knowledge on the regulation of SREBP-1 isoforms in HCC based on cellular, animal, and clinical data. Specifically, we (i) address the overarching mechanisms for regulating SREBP-1 transcription, proteolytic processing, nuclear stability, and transactivation and (ii) critically discuss their impact on HCC, taking into account (iii) insights from pharmacological approaches. Emphasis is placed on cross-talk with the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mechanistic target of rapamycin (mTOR) axis, AMP-activated protein kinase (AMPK), protein kinase A (PKA), and other kinases that directly phosphorylate SREBP-1; transcription factors, such as liver X receptor (LXR), peroxisome proliferator-activated receptors (PPARs), proliferator-activated receptor γ co-activator 1 (PGC-1), signal transducers and activators of transcription (STATs), and Myc; epigenetic mechanisms; post-translational modifications of SREBP-1; and SREBP-1-regulatory metabolites such as oxysterols and polyunsaturated fatty acids. By carefully scrutinizing the role of SREBP-1 in HCC development, progression, metastasis, and therapy resistance, we shed light on the potential of SREBP-1-targeting strategies in HCC prevention and treatment.
Localization Exploiting Semantic and Metric Information in Non-static Indoor Environments
Authors: Gomez Clara , Hernandez Alejandra C. , Barber Ramón , Stachniss Cyrill 
Published: December 2023

AbstractMobile robot localization is an important task in navigation and can be challenging, especially in non-static environments as the scene naturally involves movable objects and appearance changes. In this paper, we address the problem of estimating the robot’s pose in non-static environments containing movable objects. We understand as non-static environments, dynamic environments in which objects might be moved or changed their appearance. We propose a probabilistic localization approach that combines metric and semantic information and takes into account both, static and movable objects. We perform a pixel-wise association of depth and semantic data from an RGB-D sensor with a semantically-augmented truncated signed distance field (TSDF) in order to estimate the robot’s pose. The combination of metric and semantic information increases the robustness w.r.t. movable objects and object appearance changes. The experiments conducted in a real indoor environment and a publicly-available dataset suggest that our approach successfully estimates robot pose in non-static environments and they show an improvement compared to robot localization based only on metric or semantic information and compared to a feature-based method.
The contribution of industrial robots to labor productivity growth and economic convergence: a production frontier approach
Authors: Eder Andreas , Koller Wolfgang , Mahlberg Bernhard 
Published: December 2023

AbstractThis paper investigates the contribution of industrial robots to labor productivity growth and cross-country economic convergence in a sample of 19 developed and 16 emerging countries over the period 1999 to 2019. To answer our research questions, we extend the non-parametric production frontier framework by considering industrial robots as a separate production factor. We find a positive contribution of robotization to labor productivity growth for all countries in our sample. In the period after the financial crisis (2009 to 2019) the contribution of robot capital deepening to productivity growth gained in importance. Over the period 1999 to 2019 we find some evidence of i) unconditional β-convergence (countries with lower initial productivity levels grow faster), ii) a reduction in the dispersion of productivity levels across economies (σ-convergence) and iii) a depolarization (shift from bimodal to unimodal distribution) of the labor productivity distribution in our sample. Accumulation of ‘traditional’ physical capital is the main driver of β-convergence. Robot capital deepening significantly contributed to economic convergence and the depolarization of the labor productivity distribution, but its effect on the entire shift of the labor productivity distribution is modest and dominated by other drivers of productivity growth such as ‘traditional’ physical capital deepening and technological change.
Application of different aquatic plants in an alternated fill and drain wetland system of Phetchaburi municipal wastewater treatment in Thailand
Authors: Phewnil Onanong , Chunkao Kasem , Prabhuddham Paiboon , Pattamapitoon Thanit 
Published: December 2023

AbstractThis study evaluated the treatment efficiency of municipal wastewater from Phetchaburi in Thailand in an alternated 5-day flooding and 2-day drying wetland system with two plants species, namely, Canna indica and Heliconia psittacorum. The efficiencies of biochemical oxygen demand (BOD5) treatment were in the ranges of 90.5% ± 4.8% and 86.9% ± 7.3% for Canna and Heliconia, respectively. Those of chemical oxygen demand (COD) treatment were in the ranges of 75.5% ± 7.9% and 75.3% ± 9.0% for Canna and Heliconia, respectively. Both plants’ removal efficiencies of TN, NH4-N, and TP were greater than 40%. Lead and cadmium accumulation in both plants significantly differed between the upper and lower parts of the plants. However, the lead and cadmium accumulation in Heliconia were greater than their accumulation in Canna. Although Canna had a higher nutrient removal efficiency than Heliconia, there are many varieties of Canna in Thailand. These results indicate that the variety of Canna does not affect the nutrient removal efficiency. In conclusion, a wetland system with alternated flooding and drying conditions can be applied in communities where BOD5 and COD are the dominant wastewater pollution characteristics. Both ornamental plants are suitable absorbents for lead and cadmium, and although the accumulation is lower in Canna than in Heliconia for both heavy metals, the difference was not significant.
Metallurgical and Mechanical Investigation on Single-Step Quenching and Partitioning Thermal Treatments on Commercial Low Alloyed 30MnV6 Steel
Authors: Barella S. , Belfi M. , Gruttadauria A. , Liu C. , Peng Y. 
Published: December 2023

AbstractCharacterization of the effect of different Quenching and Partitioning treatments on retained austenite stabilization, on the final microstructure, and on tensile properties was performed on 30MnV6 microalloyed steel. The amount of retained austenite and its location into the final microstructure were evaluated through X-ray diffraction and Electron Backscattered diffraction. Moreover, different initial microstructural conditions were employed to preliminarily investigate the effect of a starting mixed austenite–ferrite microstructure on the effectiveness of the treatment, and to tailor the material final tensile properties according to its actual utilization. Amounts of retained austenite between 4.5 and 6.3 pct were observed. High tensile properties were obtained, reaching 1675 MPa of UTS, with an improved elongation with respect to the reference quenched and tempered condition, which reached 14.8 pct. Hardenability is increased by the presence of retained austenite. Intercritical condition shows lower tensile strength but an increased uniform elongation with respect to the reference quenched and partitioned condition. Therefore, quenching and partitioning appears to be a promising treatment for the selected commercial steel.
Prevalence of olfactory reference disorder according to the ICD-11 in a German university student sample
Authors: Reuter Julia , Grocholewski Anja , Steil Regina 
Published: December 2023

AbstractOlfactory reference disorder (ORD) is included as a new diagnosis in the 11th revision of the International Classification of Diseases (ICD-11). Its core symptom is persistent preoccupation with the belief that one is emitting a foul or offensive body odor or breath that is usually not perceptible to others. However, there is a lack of knowledge about the prevalence of ORD. In particular, the prevalence of the disorder has not yet been investigated using the ICD-11 diagnostic features. Therefore, this study aimed to assess the point prevalence of ORD according to the ICD-11. A total of 275 German students at university or college, aged 18–53 years, participated in an anonymous internet-based survey assessing ICD-11 essential features for ORD. The prevalence of ORD was 5.5%. Participants who met the self-rated features for ORD reported suicidal thoughts significantly more frequent than participants who did not meet the features for ORD. More than half of the participants with probable ORD reported ideas of reference and at least a strong conviction of their beliefs, suggesting poor insight. In the total sample, single symptoms of ORD were frequent. Persistent preoccupation with the belief of malodor was the most common single symptom. Distress and impairment linked to ORD symptoms were frequent. Our results suggest that ORD may be relatively common in university students and highlight the importance of future studies investigating the epidemiology of ORD as well as its suitable treatment.
Polymer Coated Urea in ‘Russet Burbank’ Potato: Yield and Tuber Quality
Authors: Taysom Trent W. , LeMonte Joshua J. , Ransom Curtis J. , Stark Jeffrey C. , Hopkins Austin P. , Hopkins Bryan G. 
Published: December 2023

AbstractNitrogen (N) fertilizer applied as polymer coated urea (PCU) may have the potential to improve potato (Solanum tuberosum L.) production. The objectives of this study were to determine the effects of PCU on potato yield and quality. ‘Russet Burbank’ potato was grown at three Idaho, USA locations. Five rates of N (0, 33, 67, 100, and 133% of the recommended rate) were applied in all combinations of: PCU applied at emergence, urea applied at emergence, or urea split-applied. The PCU-fertilized treatments produced 11%, 11%, and 10% higher US No. 1, marketable and total tuber yields, respectively, than urea-split applied. PCU trended toward increased tuber size. At equivalent rates, PCU was more efficient than urea N in providing N to potato. These results confirm findings from other researchers that a single application of PCU fertilizer, just prior to emergence, can efficiently meet seasonal N requirements for Russet Burbank potato.