bluuebunny/crossref_metadata_2025_split huggingface dataset:
A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
Authors: Liu Kaihua , Zhao Chaoxian , Adajar Reed C , DeZwaan-McCabe Diane , Rutkowski D Thomas 
Published: January 2024

AbstractCellular stresses elicit signaling cascades that are capable of either mitigating the inciting dysfunction or initiating cell death. During endoplasmic reticulum (ER) stress, the transcription factor CHOP is widely recognized to promote cell death. However, it is not clear whether CHOP also has a beneficial role during adaptation. Here, we combine a new, versatile, genetically modified Chop allele with single cell analysis and with stresses of physiological intensity, to rigorously examine the contribution of CHOP to cell fate. Paradoxically, we find that CHOP promotes death in some cells, but proliferation—and hence recovery—in others. Strikingly, this function of CHOP confers to cells a stress-specific competitive growth advantage. The dynamics of CHOP expression and UPR activation at the single cell level suggest that CHOP maximizes UPR activation, which in turn favors stress resolution, subsequent UPR deactivation, and proliferation. Taken together, these findings suggest that CHOP’s function can be better described as a “stress test” that drives cells into either of two mutually exclusive fates—adaptation or death—during stresses of physiological intensity.
The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling
Authors: Collin Vanessa , Biquand Élise , Tremblay Vincent , Lavoie Élise G , Blondeau Andréanne , Gravel Annie , Galloy Maxime , Lashgari Anahita , Dessapt Julien , Côté Jacques , Flamand Louis , Fradet-Turcotte Amélie 
Published: January 2024

AbstractViral infection often trigger an ATM serine/threonine kinase (ATM)-dependent DNA damage response in host cells that suppresses viral replication. Viruses evolved different strategies to counteract this antiviral surveillance system. Here, we report that human herpesvirus 6B (HHV-6B) infection causes genomic instability by suppressing ATM signaling in host cells. Expression of immediate-early protein 1 (IE1) phenocopies this phenotype and blocks homology-directed double-strand break repair. Mechanistically, IE1 interacts with NBS1, and inhibits ATM signaling through two distinct domains. HHV-6B seems to efficiently inhibit ATM signaling as further depletion of either NBS1 or ATM do not significantly boost viral replication in infected cells. Interestingly, viral integration of HHV-6B into the host’s telomeres is not strictly dependent on NBS1, challenging current models where integration occurs through homology-directed repair. Given that spontaneous IE1 expression has been detected in cells of subjects with inherited chromosomally-integrated form of HHV-6B (iciHHV-6B), a condition associated with several health conditions, our results raise the possibility of a link between genomic instability and the development of iciHHV-6-associated diseases.
A conserved ion channel function of STING mediates noncanonical autophagy and cell death
Authors: Xun Jinrui , Zhang Zhichao , Lv Bo , Lu Defen , Yang Haoxiang , Shang Guijun , Tan Jay Xiaojun 
Published: January 2024

AbstractThe cGAS/STING pathway triggers inflammation upon diverse cellular stresses such as infection, cellular damage, aging, and diseases. STING also triggers noncanonical autophagy, involving LC3 lipidation on STING vesicles through the V-ATPase-ATG16L1 axis, as well as induces cell death. Although the proton pump V-ATPase senses organelle deacidification in other contexts, it is unclear how STING activates V-ATPase for noncanonical autophagy. Here we report a conserved channel function of STING in proton efflux and vesicle deacidification. STING activation induces an electron-sparse pore in its transmembrane domain, which mediates proton flux in vitro and the deacidification of post-Golgi STING vesicles in cells. A chemical ligand of STING, C53, which binds to and blocks its channel, strongly inhibits STING-mediated proton flux in vitro. C53 fully blocks STING trafficking from the ER to the Golgi, but adding C53 after STING arrives at the Golgi allows for selective inhibition of STING-dependent vesicle deacidification, LC3 lipidation, and cell death, without affecting trafficking. The discovery of STING as a channel opens new opportunities for selective targeting of canonical and noncanonical STING functions.
ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation
Authors: Wang Chengdong , Liu Ziran , Zeng Yelin , Zhou Liangji , Long Qi , Hassan Imtiaz Ul , Zhang Yuanliang , Qi Xufeng , Cai Dongqing , Mao Bingyu , Lu Gang , Sun Jianmin , Yao Yonggang , Deng Yi , Zhao Qian , Feng Bo , Zhou Qin , Chan Wai Yee , Zhao Hui 
Published: January 2024

AbstractThe dorsoventral gradient of BMP signaling plays an essential role in embryonic patterning. Zinc Finger SWIM-Type Containing 4 (zswim4) is expressed in the Spemann-Mangold organizer at the onset of Xenopus gastrulation and is then enriched in the developing neuroectoderm at the mid-gastrula stages. Knockdown or knockout of zswim4 causes ventralization. Overexpression of zswim4 decreases, whereas knockdown of zswim4 increases the expression levels of ventrolateral mesoderm marker genes. Mechanistically, ZSWIM4 attenuates the BMP signal by reducing the protein stability of SMAD1 in the nucleus. Stable isotope labeling by amino acids in cell culture (SILAC) identifies Elongin B (ELOB) and Elongin C (ELOC) as the interaction partners of ZSWIM4. Accordingly, ZSWIM4 forms a complex with the Cul2-RING ubiquitin ligase and ELOB and ELOC, promoting the ubiquitination and degradation of SMAD1 in the nucleus. Our study identifies a novel mechanism that restricts BMP signaling in the nucleus.
Nuclear Magnetic Relaxation and Molecular Dynamics
Authors: Kimmich Rainer 
Published: January 2024

Interested in analysing complex systems? Have you considered nuclear magnetic relaxation studies to derive sound conclusions? Here’s how.
Nuclear Magnetic Resonance (NMR) relaxation techniques form a family of powerful tools to study and characterize liquid, solid or semi-solid materials and systems. They provide access to details directly and in wide variable ranges. This book outlines the unparalleled potential of NMR relaxation experiments to elucidate molecular dynamics. The key concepts discussed are correlation functions and spectral densities of the thermal fluctuations of spin interactions.
For users working in technology, chemical engineering, materials science, biomedicine, food science, geophysics and physical chemistry, the text explores the principles, theoretical background and descriptions of typical applications. As an essential part of relaxation data, the focus is on the statistical features of molecular dynamics. The aim is to assist the reader to acquire meaningful nuclear magnetic relaxation data sets and develop appropriate statistical models as a basis for their interpretation.
This unique text is targeted to anyone performing or interested in NMR relaxation experiments from undergraduates to academics and those in industry.
Naturalistic Developmental Behavioral Interventions for Developmental Language Disorder
Authors: Camarata Stephen , Stiles Suzanne , Birer Samara 
Published: January 2024

Purpose:

Naturalistic–developmental–behavioral interventions (NDBIs) are a widely accepted and validated approach for treating language-related symptoms in autism spectrum disorder, including deficits in vocabulary, social skills, and grammar. The purpose of this article is to define the elements
naturalistic
,
developmental
, and
behavioral
as applied to children with developmental language disorder (DLD) and to provide an example of how this type of intervention can be implemented to teach vocabulary and test cross-modal generalization between expressive and receptive modalities.

Method:
A vocabulary intervention using hybrid NDBI methods (storybook reading and conversational recast interaction) was provided to three participants with DLD using a single-case design.

Results:
The results indicated that all participants successfully learned receptive and expressive vocabulary targets with extensive cross-modal generalization. However, generalization was limited in some of the participants.

Conclusions:

This article provided definitions of key elements of NDBI (
naturalistic
,
developmental
, and
behavioral
) including a rationale for extending NDBI procedures to language intervention for children with DLD. In addition, a single-case design demonstrated that NDBI can be implemented in DLD and that broadly defined naturalistic–developmental applied behavior analysis techniques are applicable to language interventions for children with language disorders. Moreover, diverse
naturalistic
and
developmental
procedures meet the highest standards for evidence-based practice to treat DLD.
Evaluation einer eHealth-Intervention zur Tabakentwöhnung
– eine qualitative Analyse zu Zufriedenheit und
Nutzereindrücken
Authors: Maiwald Phillip , Lindinger Peter , Tinsel Iris , Fichtner Urs , Farin-Glattacker Erik , Bischoff Martina 
Published: January 2024

Zusammenfassung
Ziel der Studie  In Deutschland besteht ein Bedarf an
Interventionen zur Tabakentwöhnung, die niedrigschwellig
verfügbar sind. Eine Lösung hierfür sind
eHealth-Angebote; Forschung zu Benutzereindrücken und -zufriedenheit
hinsichtlich dieser Interventionen ist allerdings selten. Die vorliegende Studie
gewinnt detaillierte Erkenntnisse im Hinblick auf die Nutzererfahrungen von
Raucher*innen mit dem onlinebasierten
„TK-NichtraucherCoaching“.
Methodik  15
Nutzer*innen eines onlinebasierten, individualisierbaren und
interaktiven Nichtraucher-Coachings nahmen an semistrukturierten
Telefoninterviews teil. Die Gespräche wurden zur Erstellung eines
Codesystems mittels einer deduktiv-induktiven qualitativen Inhaltsanalyse nach
Kuckartz ausgewertet.
Ergebnisse  Es wurden 20
Hauptkategorien, 51 Subkategorien und 13 Sub-Subkategorien gebildet. Das finale
Codesystem umfasste 199 positiv und 90 negativ bewertende Aussagen. Besonders
die emotionale Unterstützung und die Motivierung durch das Programm, die
Niederschwelligkeit des Angebots, die optische Gestaltung, die Inhalte der
Vorbereitungsphase sowie die Erfolgsübersicht der zweiten Programmphase
wurden von den Nutzer*innen gelobt. Gemischte Ergebnisse ergaben sich
bezüglich der Individualisierungsmöglichkeiten des Programms,
der Nützlichkeit und des Umfangs der vermittelten Informationen, der
Unterstützung bei Entzugssymptomen und Rückfällen, der
Bedienung und der technischen Umsetzung sowie der optionalen telefonischen
Beratung.
Schlussfolgerung  Digitale Angebote
können einer großen Zahl von Raucher*innen einen
niederschwelligen Zugang zu Interventionen zur Tabakentwöhnung
ermöglichen. Die hier untersuchte Intervention wurde überwiegend
positiv bewertet. Durch die Erstellung eines ausführlichen Codesystems
wurden umfassende Einblicke hinsichtlich Nutzereindrücken und
Zufriedenheit der Teilnehmer*innen ermöglicht. Darauf basierend
konnten zahlreiche Optimierungsmöglichkeiten für ein solches
Angebot erarbeitet werden. Beispiele hierfür sind eine
Überarbeitung der Menüführung, eine Flexibilisierung des
Ablaufs, eine Umsetzung als Smartphone-App sowie die Bereitstellung von
textbasierten Chats.
Prädiktoren der Erledigung bei nach §64 StGB
untergebrachten Patienten – Ein Literaturreview
Authors: Scheuschner Lene , Walde Peggy , Völlm Birgit 
Published: January 2024

Zusammenfassung
Hintergrund Bei nach §64 StGB untergebrachten suchtkranken
Straftätern kann die Unterbringung vorzeitig beendet werden. Es liegt
eine umfangreiche Literatur zu Prädiktoren einer vorzeitigen Beendigung
vor Therapiebeginn vor.
Zielsetzung Ziel dieser Arbeit ist es, Prädiktoren einer
vorzeitigen Erledigung während des Therapieverlaufs darzustellen.
Methodik Es wurde eine systematische Literaturrecherche
durchgeführt und 16 Publikationen eingeschlossen.
Ergebnisse Sowohl Patienten als auch Therapeuten sehen vor allem
Impulsivität/Aggressivität,
Suchtmittelrückfälle und eine mangelnde
Patient-Therapeuten-Beziehung als negative Prädiktoren. Beide Gruppen
schreiben dem Vorhandensein von Motivation und einem positiven sozialen Netzwerk
förderlichen Einfluss auf das Outcome zu.
Schlussfolgerung Für ein erfolgreiches Beenden der Unterbringung
sind eine tragfähige Patienten-Therapeuten-Beziehung, Motivationsarbeit
und das Aufarbeiten von Vorfällen essentiell.
Freizeitdrogenkonsum und Drug Checking
Authors: Schori Dominique 
Published: January 2024

ZusammenfassungDrug Checking ist ein Angebot der Schadensminderung und richtet sich
hauptsächlich an Freizeitdrogenkonsumierende. Im Zentrum des Angebots
steht die Vermittlung von Konsumkompetenz sowie die Sensibilisierung für
Konsumrisiken, basierend auf laboranalytischen Fakten. Drug-Checking-Angebote
gibt in wachsender Zahl in verschiedenen europäischen Städten.
Die politische Akzeptanz für Drug Checking als Instrument der
Schadensminderung steigt, zunehmend rückt aber auch die Bedeutung von
Drug Checking zum Monitoring des illegalen Drogenmarktes in den Fokus.
Drug-Checking-Angebote müssen sich kontinuierlich an den sich
ändernden Konsum- und Marktrealitäten anpassen und spielen eine
zentrale Rolle bei der Diskussion rund um die Regulierung von illegalen
Substanzen (z. B. Cannabis).
Good Outcome of Resective Epilepsy Surgery in a 1-Year-Old Child with Drug-Resistant Focal Epilepsy with a Novel Pathogenic COL4A1 Mutation
Authors: Fearns Nicholas , Wagner Matias , Borggräfe Ingo , Kunz Mathias , Rémi Jan , Vollmar Christian 
Published: January 2024

AbstractPathogenic variants in COL4A1, encoding the α chain of type IV collagen, have been associated with cerebrovascular pathology as well as malformations of cortical development, thereby causing structural epilepsy. This case illustrates successful resective epilepsy surgery in a 12-month-old girl with left occipital focal cortical dysplasia (FCD) associated with a heterozygous splice-donor variant in COL4A1. She presented with drug-resistant focal epilepsy with daily seizures from the age of 2 months, refractory to several combinations of antiseizure medications, as well as mild right-sided hemiparesis and developmental delay. All presurgical diagnostic modalities, including ictal and interictal electroencephalography, magnetic resonance imaging, and ictal fluorodeoxyglucose positron emission tomography, showed congruent findings, pointing toward one single left occipital epileptogenic zone (EZ). We performed a left occipital lobectomy, using intraoperative electrocorticography to confirm the boundaries of the EZ. After surgery, the patient has remained seizure free, and both cognitive and motor developments have improved. Histopathology of the resected brain tissue showed FCD type Ia. Resective epilepsy surgery can have a very good outcome, also in patients with genetic mutations in COL4A1, constituting a less invasive option than the previously used more radical surgical procedures such as hemispherectomy.
Design of Imidazo[1,2-a]pyridine-Based Donor–Acceptor Chromophores through a Multicomponent Approach
Authors: Zysman-Colman Eli , Bräse Stefan , Stahlberger Mareen , Mergel Milada , dos Santos John Marques , Matulaitis Tomas , Nieger Martin 
Published: January 2024

AbstractA series of donor-acceptor chromophores was synthesized bearing a 3-aminoimidazo[1,2-a]pyridine donor motive. Through DFT calculations, different combinations of the ImPy donor motive and different electron acceptors were assessed. In combination with an anthraquinone acceptor, the calculated ΔE
ST values were in range to suggest that these compounds would emit via thermally activated delayed fluorescence. Based on these findings, a series of ImPy-Aq emitters with different geometries and substitution patterns was synthesized through GBB-3CR and Suzuki coupling reactions. According to preliminary experimental data, the compounds were only slightly emissive at ambient temperatures due to a combination of low radiative rates and competing non-radiative deactivation pathways.
Condensation of Amines with S-Methyl Thiouronium Salts: Another Entry for the Synthesis of Amidines
Authors: Swaroop Toreshettahally R. , Torun Lokman , Bakyyev Rahym , Rangappa Kanchugarakoppal S. 
Published: January 2024

AbstractWe present a condensation of primary aryl or alkyl amines with S-methyl thiouronium salts to obtain N,N,N′-trisubstituted amidines. High yields, short reaction times, and a fair substrate scope are the noteworthy features of this protocol. Surprisingly, the reaction of a thiouronium salt with 4-aminopyridine gave 1-(4-methoxybenzoyl)piperidine.
Sultines as o-Quinodimethane Precursors in an Oxa-Diels–Alder Reaction: Synthesis of Functionalized Isochromans
Authors: Ngamnithiporn Aurapat , Chuentragool Padon , Songthammawat Poramate , Punnita Supakarn , Photong Kittithuch , Ploypradith Poonsakdi , Ruchirawat Somsak 
Published: January 2024

AbstractThe development of an oxa-Diels–Alder reaction between sultines and carbonyl compounds is reported. o-Quinodimethanes, generated from sultines, undergo a [4+2]-cycloaddition with activated aldehydes or ketones in the presence of Cu(OTf)2 to provide a variety of functionalized isochromans, including spiroisochromans, in up to 99% yield. The developed protocol demonstrates broad functional-group compatibility and tolerates unprotected isatins bearing free NH-functionalities.
Linear and nonlinear relationships between instructional leadership and teacher professional learning through teacher self-efficacy as a mediator: a partial least squares analysis
Authors: Thien Lei Mee , Liu Peng 
Published: January 2024

AbstractAlthough the investigation of instructional leadership and teacher professional learning is well-documented in the literature, one overlooked question concerns the linear and nonlinear relationships between these two variables. This study aims to examine the linear and nonlinear relationships of principal instructional leadership on teacher professional learning through teacher self-efficacy as a mediator. This study has collected 335 teacher samples encompassing both primary and secondary school levels in Penang, Malaysia. The analysis of data utilised partial least-squares structural equation modelling. The findings indicated a significant positive linear relationship between instructional leadership and teacher-professional learning. Likewise, there exists a significant mediating effect of teacher self-efficacy between instructional leadership on teacher professional learning. There exists a significant nonlinear relationship between principal instructional leadership on teacher self-efficacy and teacher professional learning respectively. The structural model exhibits a significantly high level of predictive power for in-sample and out-of-sample. This study offers theoretical and methodological advancements in comprehending the complex relationships between instructional leadership and teacher outcomes. It proposes that forthcoming studies could adopt a combination of linear and non-linear relationships to achieve robust empirical findings.
Community-based management for low-digitalized communities using cross-cutting purchasing behavior
Authors: Ieiri Yuya , Yamaki Kaishu , Hishiyama Reiko 
Published: January 2024

AbstractThe need for community-based management to revitalize the economy of commercial areas by using consumer behavior analysis focusing on transactions has increased. Low-digitalized shopping communities, commercial communities that include retailing that have not introduced digital technologies, require community-based management using consumer behavior analysis. However, low-digitalized shopping communities cannot collect cross-cutting consumer behavior data using digital technologies such as point of sales (POS) systems. This difficulty obscures the novel management potential of applying such customer behavior analysis to community-based management. Our study aims to bridge the gap between low-digitalized shopping communities and community-based management using customer behavior analysis. To achieve this purpose, this study proposed a novel management approach using data collected using paper-based community currencies and its analysis method. Two field experiments were performed in low-digitalized shopping communities in Japan using two types of community currencies: from-to (FT) and customer attributes (CA). This study illustrated the possibility of community-based management in low-digitalized shopping communities and extending conventional retailing management methods using customer behavior analysis to community-based management.
The persuasive power of social media influencers in brand credibility and purchase intention
Authors: Liu Xiao , Zheng Xiaoyong 
Published: January 2024

AbstractThe use of social media influencer collaboration is growing exponentially. This study explores the persuasive power of influencers on followers’ perceived brand credibility and purchase intention by applying the elaboration likelihood model of persuasion. The results show that the informative value of influencers’ content, authenticity, and homophily positively affect their parasocial relationships, which in turn, affects followers’ purchase intention and evaluation of brand credibility. Followers’ persuasion knowledge negatively moderates the relationship between parasocial relationships and followers’ perceived brand credibility; it has no moderating effect on the relationship between parasocial relationships and followers’ purchase intention.
Simulation of population size and economic scale supportable by the Yellow River’s available freshwater in 2030 under multiple scenarios
Authors: Guo Lishuo , Song Xiaogang , Wang Qi 
Published: January 2024

AbstractThe Yellow River plays a crucial role in China’s socioeconomic development and ecological security. The amount of freshwater available for allocation to the nine provinces of the Yellow River basin (YRB) is expected to be 39.485 billion m3 in 2030, for a projected population of 0.13094 billion people. This study aimed to simulate the sustainable population size and economic scale attainable with the Yellow River’s restricted freshwater supply. We forecasted population size and economic scale under various scenarios using a water resource carrying capacity (WRCC) prediction model. Further, the most likely scenarios—high, moderate, and low development—were analyzed based on historical trends. The results showed that by 2030, the available freshwater could support population sizes of 0.16, 0.152, and 0.147 billion under the high-, moderate-, and low-development scenarios, respectively, all of which are greater than 0.13094 billion. Moreover, economic scales of CNY17.5 trillion ($2.52 trillion), CNY15.01 trillion ($2.18 trillion), and CNY13.2 trillion ($1.91 trillion) could be supported under the high-, moderate-, and low-development scenarios, respectively. This study’s contributions are that (1) using population size and economic scale to characterize WRCC overcomes the limitation of measuring WRCC with a dimensionless index; (2) quantifying WRCC overcomes the flaws of single-trend measurement; and (3) the scenarios paint a clear picture of the YRB’s future water security and socioeconomic development. Our findings could help steer the direction of future water-, population-, and economy-related policymaking.