bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting user‐subjective categorization with self‐organizing maps and learning vector quantization
Authors: Goren‐Bar Dina , Kuflik Tsvi 
Published: December 2004

AbstractToday, most document categorization in organizations is done manually. We save at work hundreds of files and e‐mail messages in folders every day. While automatic document categorization has been widely studied, much challenging research still remains to support user‐subjective categorization. This study evaluates and compares the application of self‐organizing maps (SOMs) and learning vector quantization (LVQ) with automatic document classification, using a set of documents from an organization, in a specific domain, manually classified by a domain expert. After running the SOM and LVQ we requested the user to reclassify documents that were misclassified by the system. Results show that despite the subjective nature of human categorization, automatic document categorization methods correlate well with subjective, personal categorization, and the LVQ method outperforms the SOM. The reclassification process revealed an interesting pattern: About 40% of the documents were classified according to their original categorization, about 35% according to the system's categorization (the users changed the original categorization), and the remainder received a different (new) categorization. Based on these results we conclude that automatic support for subjective categorization is feasible; however, an exact match is probably impossible due to the users' changing categorization behavior.
Interaction between the ADH1C polymorphism and maternal alcohol intake in the risk of nonsyndromic oral clefts: An evaluation of the contribution of child and maternal genotypes
Authors: Chevrier Cécile , Perret Claire , Bahuau Michel , Nelva Agnès , Herman Christine , Francannet Christine , Robert‐Gnansia Elisabeth , Cordier Sylvaine 
Published: December 2004

AbstractBACKGROUNDMaternal alcohol consumption has been associated with an increased risk of nonsyndromic oral clefts in some studies. Study of gene‐environment interaction may provide insight into the reasons for their discrepancies observed. We focused on a polymorphism of the ADH1C gene (third gene of the class I alcohol dehydrogenase family), involved in the metabolism of ethanol and other alcohols.METHODSData come from a French case‐control study (1998–2001), which tested the association between maternal alcohol consumption during the first trimester of pregnancy and the risk of nonsyndromic oral clefts (240 cases, 236 controls). A case‐parent study design looked at the association with an ADH1C polymorphism (Ile349Val site) and potential gene‐environment interaction effects. A log‐linear model was used to distinguish the direct effect of the child's genotype from the maternally mediated effects.RESULTSAn increased risk of nonsyndromic oral clefts was observed for women who reported drinking alcohol during the first trimester, compared with women who did not. The mutated ADH1C allele carried by the child seemed to have a protective effect against the risk of oral clefts (RRone copy, 0.71; 95% confidence interval [CI], 0.50–1.02; RRtwo copies, 0.63; 95% CI, 0.3–1.3). The maternal genotype played a less important role than the child's, and its action remains unclear. No significant evidence of interaction effects between the ADH1C genotype and maternal alcohol consumption was observed.CONCLUSIONSBecause the ADH1C gene is involved in the metabolic pathways of many alcohols, we propose several hypotheses about the causal pathway, including ethanol oxidation activity and, more probably, retinol oxidation. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.
Metal‐Binding Properties of the Peptide APP170–188: A Model of the ZnII‐Binding Site of Amyloid Precursor Protein (APP)
Authors: Ciuculescu Eliza‐Diana , Mekmouche Yasmina , Faller Peter 
Published: December 2004

AbstractAmyloid precursor protein (APP) plays a key role in Alzheimer's disease (AD), although the function of this membrane protein is still unclear. Metal ions are implicated in AD and they also interact with APP. APP possesses a strong ZnIIbinding site, which is evolutionary conserved. In this paper a synthetic peptide, APP170–188, with a sequence corresponding to the conserved ZnII‐binding domain of APP, was synthesised and its metal‐binding properties analysed. Titration experiments pointed to the binding of a stoichiometric amount of divalent ions. Further studies indicated that the binding of divalent metals like ZnII, CdIIand CoIIinduces the dimerisation of the peptide. This dimer contains a dinuclear cluster in which the two divalent metals are bridged by two thiolate ligands from cysteine residues. The other two ligands of the tetrahedral coordination sites of each metal ion are terminal thiolate ligands. This structure was supported by the following arguments. The complex formed with CoIIpresents the characteristic features for tetrahedral tetrathiolate coordination in its UV‐visible spectrum. The sequence of APP170–188contains only three cysteine residues, which is incompatible with a monomeric CoII–APP170–188complex. EPR measurements of the complex with one equivalent of CoIIshow almost no signal at 4 K, which is compatible with an antiferromagnetic spin‐coupling of the metal ions in a cluster structure. Size‐exclusion chromatography indicated that the elution time for the complexes with ZnIIand CdIIcorresponds to the expected molecular weight of a dimer. The circular dichroism (CD) spectrum of the complex with one equivalent of CdIIshows a band at 265 nm(+), and an ellipticity similar to those observed for similar CdII–thiolate clusters. Possible biological implications of the ZnIIbinding site and the metal‐induced dimerisation are discussed.
Thermal and Photolytic Reactions of Group 12 Metal Atoms in HCl‐Doped Argon Matrices: Formation and Characterization of the Hydride Species HMCl (M: Zn, Cd, or Hg).
Authors: Macrae Victoria A. , Green Jennifer C. , Greene Tim M. , Downs Antony J. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective Synthesis of Non‐Natural Amino Acids Using Phenylalanine Dehydrogenases Modified by Site‐Directed Mutagenesis.
Authors: Busca Patricia , Paradisi Francesca , Moynihan Eamonn , Maguire Anita R. , Engel Paul C. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Interaction of Fluorinated 2‐Arylhydrazone‐1,3‐dicarbonyl Compounds with o‐Phenylenediamine.
Authors: Khudina O. G. , Shchegol'kov E. V. , Burgart Ya. V. , Saloutin V. I. , Chupakhin O. N. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of C3‐Symmetric Nano‐Sized Polyaromatic Compounds by Trimerization and Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Kotha Sambasivarao , Kashinath Dhurke , Lahiri Kakali , Sunoj Raghavan B. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐Benzyl‐2‐chloroindole‐3‐carboxylic Acids as Potential Antiinflammatory Agents. Synthesis and Screening for the Effects on Human Neutrophil Functions and on COX1/COX2 Activity.
Authors: Andreani Aldo , Granaiola Massimiliano , Leoni Alberto , Locatelli Alessandra , Morigi Rita , Rambaldi Mirella , Roda Aldo , Guardigli Massimo , Traniello Serena , Spisani Susanna 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cross‐Condensation of Derivatives of Cyanoacetic Acid and Carbonyl Compounds. Part 2. One‐Pot Synthesis of Substituted 2‐Amino‐7‐methyl‐5‐oxo‐4,5‐dihydropyrano[4,3‐b]pyrans in Ethanol and Ionic Liquid [bmim][PF6].
Authors: Shestopalov A. M. , Zlotin S. G. , Shestopalov A. A. , Mortikov V. Yu. , Rodinovskaya L. A. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Pyrrolo[1,2‐a][3.1.6]benzothiadiazocine Ring Synthesis. Unusual Truce—Smiles Type Rearrangement of 1‐{[1‐(2‐Nitrophenyl)‐1H‐pyrrol‐2‐yl]sulfonyl (or sulfinyl)}acetone.
Authors: Kimbaris Athanasios , Cobb Jonathan , Tsakonas Georgios , Varvounis George 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Briaexcavatolides X—Z, Three New Briarane‐Related Derivatives from the Gorgonian Coral Briareum excavatum.
Authors: Sung Ping‐Jyun , Hu Wan‐Ping , Wu Shwu‐Li , Su Jui‐Hsin , Fang Lee‐Shing , Wang Jeh‐Jeng , Sheu Jyh‐Horng 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Simple and Efficient per‐O‐Acetylation of Carbohydrates by Lithium Perchlorate Catalyst.
Authors: Lu Kuo‐Cheng , Hsieh Shu‐Yi , Patkar Laxmikant N. , Chen Chien‐Tien , Lin Chun‐Cheng 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Conversion of N‐Acetylneuraminic Acid Glycosyl Chloride into Dibenzyl Glycosyl Phosphate: O‐Glycosylation in the Absence of a Promoter.
Authors: Shpirt A. M. , Kononov L. O. , Torgov V. I. , Shibaev V. N. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Modified predictor–corrector numerical scheme for real‐time pseudo dynamic tests using state‐space formulation
Authors: Zhang Yunfeng , Sause Richard , Ricles James M. , Naito Clay J. 
Published: December 2004

AbstractThis paper deals with an explicit numerical integration method for real‐time pseudo dynamic tests. The proposed method, termed the MPC‐SSP method, is suited to use in real‐time pseudo dynamic tests as no iteration steps are involved in each step of computation. A procedure for implementing the proposed method in real‐time pseudo dynamic tests is described in the paper. A state‐space approach is employed in this study to formulate the equations of motion of the system, which is advantageous in real‐time pseudo dynamic testing of structures with active control devices since most structural control problems are formulated in state space. A stability and accuracy analysis of the proposed method was performed based on linear elastic systems. Owing to an extrapolation scheme employed to predict the system's future response, the MPC‐SSP method is conditionally stable. To demonstrate the effectiveness of the MPC‐SSP method, a series of numerical simulations were performed and the performance of the MPC‐SSP method was compared with other pseudo dynamic testing methods including Explicit Newmark, Central Difference, Operator Splitting, and OS‐SSP methods based on both linear and non‐linear single‐degree‐of‐freedom systems. Copyright © 2004 John Wiley & Sons, Ltd.
The role of sensation seeking and need for cognition on Web‐site evaluations: A resource‐matching perspective
Authors: Martin Brett A. S. , Sherrard Michael J. , Wentzel Daniel 
Published: December 2004

AbstractThe Internet theoretically enables marketers to personalize a Web site to an individual consumer. This article examines optimal Website design from the perspective of personality trait theory and resource‐matching theory. The influence of two traits relevant to Internet Web‐site processing—sensation seeking and need for cognition —were studied in the context of resource matching and different levels of Web‐site complexity. Data were collected at two points of time: personality‐trait data and a laboratory experiment using constructed Web sites. Results reveal that (a) subjects prefer Web sites of a medium level of complexity, rather than high or low complexity; (b) high sensation seekers prefer complex visual designs, and low sensation seekers simple visual designs, both in Web sites of medium complexity; and (c) high need‐for‐cognition subjects evaluated Web sites with high verbal and low visual complexity more favorably. © 2005 Wiley Periodicals, Inc.
An experimental study of credibility in e‐negotiations
Authors: Citera Maryalice , Beauregard Russell , Mitsuya Takashi 
Published: December 2004

AbstractE‐negotiators' credibility was compared to that of face‐to‐face (FTF) negotiators in an integrative bargaining task. Dyads were randomly assigned to negotiate either on the computer or FTF. E‐negotiators perceived their opponents to be less credible and reported less selfcredibility than FTF negotiators. Although lying did not vary significantly from FTF to e‐negotiations, self‐credibility and lying were negatively correlated. E‐negotiators were also more likely to advocate using dishonesty in the future. Consistent with psychological distance theory, skepticism regarding the credibility of e‐negotiators appears warranted. © 2005 Wiley Periodicals, Inc.
Mass spectrometric analysis of the glycosphingolipid‐enriched microdomains of rat natural killer cells
Authors: Man Petr , Novák Petr , Cebecauer Marek , Horváth Ondrej , Fišerová Anna , Havlíček Vladimír , Bezouška Karel 
Published: December 2004

AbstractGlycosphingolipid‐enriched microdomains (GEM) are membrane entities that concentrate glycosylphosphatiolylinositol(GPI)‐anchored, acylated and membrane proteins important for immune receptor signaling. Using rat leukemic cell line RNK‐16 we have initiated proteomic studies of microdomains in natural killer (NK) cells. Isolated plasma membranes were treated with Brij 58, or Nonidet‐P40, or sodium carbonate. Extracts were separated by sucrose density gradient centrifugation into very light membrane, medium light membrane and heavy fractions, and a complete protein profile was analyzed by tandem mass spectrometry. Up to 250 proteins were unambiguously identified in each analyzed fraction. The first study of the proteome of NK cell GEM revealed several new aspects including identification of molecules not expected to be expressed in rat NK cells (e.g., NAP‐22) or associated with GEM (e.g., NKR‐P1, CD45, CD2). Moreover, it provided clear data consolidating controversial views concerning the occurrence of major histcompatibility complex glycoproteins and RT6.1/CD73/CD38 complex in NK cells. Our results also identified a large number of receptors as candidates for future functional studies.
A modified tandem affinity purification tag technique for the purification of protein complexes in mammalian cells
Authors: Drakas Robert , Prisco Marco , Baserga Renato 
Published: December 2004

AbstractThe tandem affinity purification (TAP) tag technique has been used with success to identify under nondenaturing conditions protein complexes in yeast. The technique can be used in mammalian cells, but we found that the original technique does not yield enough recovery for the identification of proteins when mammalian cells growing in monolayer have to be used. We present here a modified TAP tag technique that allows sufficient recovery of proteins from mouse fibroblasts growing in monolayer cultures. The recovery allows protein identification by mass spectrometry.
Proteomic analysis of the proliferative and secretory phases of the human endometrium: Protein identification and differential protein expression
Authors: DeSouza Leroi , Diehl Georg , Yang Eric C.C. , Guo Jingzhong , Rodrigues Mary Joe , Romaschin Alexander D. , Colgan Terence J. , Siu K.W. Michael 
Published: December 2004

AbstractProteomic analyses of the proliferative and secretory phases of the human endometrium were carried out to identify proteins and discover differentially expressed proteins using isotope‐coded affinity tags, three stages of chromatographic separation and online tandem mass spectrometry (MS/MS). From an initial list of 346 proteins identified by ProICAT, manual inspection of MS/MS spectra and confirmatory searches pared the list down to 119 positively identified proteins. Only five of the proteins showed consistent differential expression. The utility of some of these proteins as indicators of true differential expression in the endometrium is open to discussion. The two proteins with unquestionable differential expressions in the secretory endometrium are: glutamate NMDA receptor subunit zeta 1 precursor and FRAT1. Some of the proteins that show no differential expression have previously been examined in gene‐expression studies with similar conclusions.
Preparation and characterization of biotinylated and enzyme‐immobilized heterobifunctional latex particles as nanobio devices
Authors: Du Yong‐Zhong , Kodaka Masato 
Published: December 2004

AbstractA novel biotinylated and enzyme‐immobilized nanobio device was prepared with heterobifunctional composite latex particles. Hemispherical poly(glycidyl methacrylate‐co‐divinylbenzene)/polystyrene [P(GMA‐DVB)/PSt] particles with epoxy and hydroxyl groups were prepared by soap‐free seeded emulsion polymerization with P(GMA‐DVB) seed particles. Hydroxyl groups were introduced to PSt chain terminals in the seeded stage by adding 2‐mercaptoethanol as a chain‐transfer agent. To obtain the desired hemispherical structure particles, we studied the effects of the preswelling process, the type and amount of solvents added in the seeded polymerization step, the weight ratio of the secondary monomer (styrene) to the seed particle (M/P), and the type of initiators. Under suitable conditions, heterobifunctional P(GMA‐DVB)/PSt was obtained, which was confirmed by observing the binding of streptavidin–colloidal gold with transmission electron microscopy (TEM). To obtain biotinylated and enzyme‐immobilized particles, 5‐(N‐succinimidyloxycarbonyl)pentyl D‐biotinamide was first reacted with the hydroxyl group on the PSt domain of the particle. Pyruvate kinase (PK) was then directly immobilized to the biotinylated particles through a reaction with the epoxy group in the PGMA domain. The monolayer of PK on the latex particle surface was considered to be formed by covalent binding. The activity of immobilized PK was almost conserved, even after being stored at 4 °C for 48 days. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 562–574, 2005
A system for wind power estimation in mountainous terrain. Prediction of Askervein hill data
Authors: Eidsvik Karl J. 
Published: December 2004

AbstractIn mountainous terrain, where the wind power potential is largest, the estimation of the local wind power can be done rationally by means of available information about the large‐scale flow and the detailed terrain and numerical flow models for downscaling, provided that the numerical model estimates can be assigned sufficient confidence. In this study the confidence of a local model in such an estimation system is discussed. The model is based upon the Reynolds‐averaged Navier–Stokes equations with (K, ϵ) turbulence closure and integrated with finite element numerical techniques. The model has previously been validated relative to complicated laboratory‐scale flows and appears to predict some full‐scale geophysical flows plausibly. Here its predictions are compared quantitatively with the full‐scale Askervein hill experimental data. The model estimates the data to within the experimental uncertainty, which we judge to be comparable to 10%, as other comparable models also do. This contributes to assign confidence to the downscaling estimation system mentioned. Copyright © 2004 John Wiley & Sons, Ltd.
Ionizing radiation‐induced damage on developing cerebellar granule cells cultures can be prevented by an early amifostine post‐treatment
Authors: Guelman Laura Ruth , Cabana Javier Ignacio , Pagotto Romina María del Luján , Zieher Luis María 
Published: December 2004

AbstractDeveloping central nervous system (CNS) is highly sensitive to ionizing radiation due, in part, to reactive oxygen species (ROS) damage.A variety of compounds able to protect brain cells essentially by decreasing ROS production have been widely used to confirm ROS participation in different mechanisms of brain injury, as well as to evaluate them as therapeutic tools.To test if ionizing radiation‐induced damage on immature cerebellar granule cells is mainly mediated by ROS accumulation, a free radical scavenger –amifostine (amf) – was used in an in vitro model. Moreover, the amf therapeutic effect was investigated.Results show that only an early (20–30 min) post‐treatment with amf, acting through an antioxidant mechanism, has been effective in preventing cerebellar granule cell loss observed after ionizing radiation exposure in vitro.These data suggest that immature cerebellar granule cells grown in vitro are highly vulnerable to ROS damage and that a therapeutic intervention could be effective in a narrow temporal window. Moreover, radiation‐induced cell death can be partially prevented by a complete limitation of ROS generation, suggesting that other mechanisms besides oxidative stress would also be responsible for the cellular damage found in this model.
Limitations of the pelvic examination for evaluation of the female pelvic organs
Authors: Padilla L.A. , Radosevich D.M. , Milad M.P. 
Published: December 2004

AbstractObjectiveTo assess factors influencing an accurate pelvic examination under the best possible circumstances.MethodsBefore undergoing laparoscopy or laparotomy, 84 women under general anesthesia underwent pelvic examinations by an attending gynecologist, a gynecology resident, and a medical student blinded to the indication for surgery. Surgical findings were compared with the examiners' findings. Dependent variables (uterine size, uterine contour, and presence of adnexal masses) and effect modifiers (examiner experience and body mass index) were analyzed.ResultsThe overall pelvic examination was accurate 70.2% of the time for attending gynecologists, 64.0% for residents, and 57.3% for medical students. The sensitivity to detect adnexal masses was much lower than the sensitivity to assess uterine size or uterine contour. Obesity noticeably reduced detection of adnexal masses.ConclusionThe bimanual examination appears to be a limited screening test for the female upper genital tract even under the best possible circumstances. Uterine assessment appears to be more accurate than adnexal assessment.
Visual inspection of the cervix with acetic acid for cervical intraepithelial lesions
Authors: Goel A. , Gandhi G. , Batra S. , Bhambhani S. , Zutshi V. , Sachdeva P. 
Published: December 2004

AbstractObjective: Evaluation of visual inspection of the cervix with acetic acid (VIA) for screening cervical intraepithelial neoplasia. Methods: In this prospective study, 400 women were screened using the Papanicolaou (PAP) smear, VIA and colposcopy. Those who had positive results with any of the screening methods underwent large loop excision of the transformation zone (LLETZ). The sensitivity and specificity of each of the screening methods was analyzed. Results: The sensitivity of VIA (96.7%) was much higher than that of the Pap smear (50%), and almost as high as that of colposcopy (100%). The specificity of VIA (36.4%) was lower than that of the Pap smear (97%) and colposcopy (96.9%), resulting in high false‐positive rates for VIA. Two cases of endocervical lesions were missed with VIA. Conclusion: Visual inspection of the cervix with acetic acid is very sensitive for ectocervical lesions. The advantages of the VIA method are its low cost and ease of use (it can be used by paramedical workers), its high sensitivity and its immediate results (it is possible to “see and treat” at the first visit). Its main limitation is a high rate of false‐positive results, which may lead to overtreatment if a “see and treat” policy is applied.