bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting survival in patients with buccal cancer: A study based on SEER database and external validation in China
Authors: Tan Yongmei , Huang Guoxing , Hu Jintao , Zhao Shaoping , Li Yanyan , Wen Zhihui , Wang Liansheng , Chen Suling , Chen Rongxi , Cao Haotian , Li Jinsong 
Published: January 2024

AbstractObjectiveBuccal mucosa cancer (BMC) is one of the most common oral cancers and has poor prognosis. The study aimed to develop and validate nomograms for predicting the 1‐, 3‐, and 5‐year overall survival (OS) and cancer‐specific survival (CSS) of BMC patients.MethodsWe collected and reviewed information on BMC patients diagnosed between 2004 and 2019 from the Surveillance Epidemiology and End Results database. Two nomograms were developed and validated to predict the OS and CSS based on predictors identified by univariate and multivariate Cox regression. An extra external validation was further performed using data from Sun Yat‐sen Memorial Hospital (SYSMH).ResultsA total of 3154 BMC patients included in this study were randomly assigned to training and validation groups in a 2:1 ratio. Independent prognostic predictors were identified, confirmed, and fitted into nomograms for OS and CSS, respectively. The C‐indices are 0.767 (Training group OS), 0.801 (Training group CSS), 0.763 (Validation group OS), and 0.781 (Validation group OS), respectively. Moreover, the nomograms exhibited remarkable precision in forecasting and significant clinical significance, as evidenced by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analyses (DCA). The final validation using our data from SYSMH also showed high accuracy and substantial clinical benefits within the nomograms. The C‐indices are 0.849 (SYSMH group OS) and 0.916 (SYSMH group CSS). These indexes are better than tumor, node, and metastasis stage based on prediction results.ConclusionsThe nomograms developed with great performance predicted 1‐, 3‐, and 5‐year OS and CSS of BMC patients. Use of the nomograms in clinical practices shall bring significant benefits to BMC patients.
Individuals' materialism and brand rituals and traditions as drivers of luxury brand love on social media
Authors: Cruz‐Ros Sonia , Miquel‐Romero Maria‐Jose , Yee Rachel W. Y. 
Published: January 2024

AbstractLuxury brands have engaged in social media use, becoming exposed to a wider market but confronting the exclusivity and uniqueness linked to these brands. This paper explores the role of a personality trait and a brand characteristic in brand love by social media users in the luxury fashion industry. Specifically, the individual's materialism (measured by the relevance given to luxury premium prices and fashionability), the essence of the brand perceived through its rituals and traditions, and their influence on self–brand integration are considered. An empirical study is carried out on 432 social media users, and two different research methodologies are conducted: Partial Least Squares Structural Equation Modelling (PLS‐SEM) and fuzzy‐set Qualitative Comparative Analysis (fsQCA). Findings from both methodologies support the relevance of the variables analysed with regard to brand love. However, fsQCA offers a new perspective by identifying that for loving the brand, materialistic individuals also have to value the brand's rituals and traditions; and that personality traits can contribute to brand love, the resultant outcome of the relevance given to a luxury premium price, or to its aesthetic and fashionability, but not to both aspects at the same time; finally, self–brand integration is not necessary for brand love but is sufficient. From these results, managerial implications are suggested in order to favour brand love, as it exerts a strong influence on purchase intention.
Synthesis of Amino Acid‐Based Cationic Lipids and Study of the Role of the Cationic Head Group for Enhanced Drug and Nucleic Acid Delivery
Authors: Mandal Subhasis , Mallik Suman , Bhoumick Avinandan , Bhattacharya Anindita , Sen Prosenjit 
Published: January 2024

AbstractLeveraging liposomes for drug and nucleic acid delivery, though promising due to reduced toxicity and ease of preparation, faces challenges in stability and efficiency. To address this, we synthesized cationic amphiphiles from amino acids (arginine, lysine, and histidine). Histidine emerged as the superior candidate, leading to the development of three histidine‐rich cationic amphiphiles for liposomes. Using the hydration method, we have prepared the liposomes and determined the optimal N/P ratios for lipoplex formation via gel electrophoresis. In vitro transfection assays compared the efficacy of our lipids to Fugene, while MTT assays gauged biocompatibility across cancer cell lines (MDA‐MB 231 and MCF‐7). The histidine‐based lipid demonstrated marked potential in enhancing drug and nucleic acid delivery. This improvement stemmed from increased zeta potential, enhancing electrostatic interactions with nucleic acids and cellular uptake. Our findings underscore histidine‘s crucial role over lysine and arginine for effective delivery, revealing a significant correlation between histidine abundance and optimal performance. This study paves the way for histidine‐enriched lipids as promising candidates for efficient drug and nucleic acid delivery, addressing key challenges in the field.
The Impact of Activating Agents on Non‐Enzymatic Nucleic Acid Extension Reactions
Authors: Callaghan Kimberley L. , Sherrell Peter C. , Ellis Amanda V. 
Published: January 2024

AbstractNon‐enzymatic template‐directed primer extension is increasingly being studied for the production of RNA and DNA. These reactions benefit from producing RNA or DNA in an aqueous, protecting group free system, without the need for expensive enzymes. However, these primer extension reactions suffer from a lack of fidelity, low reaction rates, low overall yields, and short primer extension lengths. This review outlines a detailed mechanistic pathway for non‐enzymatic template‐directed primer extension and presents a review of the thermodynamic driving forces involved in entropic templating. Through the lens of entropic templating, the rate and fidelity of a reaction are shown to be intrinsically linked to the reactivity of the activating agent used. Thus, a strategy is discussed for the optimization of non‐enzymatic template‐directed primer extension, providing a path towards cost‐effective in vitro synthesis of RNA and DNA.
Performance evaluation of maltogenic amylases on nixtamalized corn flour tortilla
Authors: Leung Sophia , Go Angel Lene , Keo Malissa , Al‐Ammar Assad , Roda Dipak , Rathi Vic 
Published: January 2024

AbstractBackground and ObjectivesA high‐performing maltogenic amylase was developed to provide better water‐binding properties to delay staling more effectively than first‐generation maltogenic amylases. This study evaluated the effects of this high‐performing maltogenic amylase and a first‐generation maltogenic amylase (referred to as “maltogenic amylase”) for delaying staling in nixtamalized corn flour tortillas. The maltogenic amylase and high‐performing maltogenic amylase were tested at 25, 50, and 100 ppm and were compared to control tortillas.FindingsTortillas with 100 ppm high‐performing maltogenic amylase were 66% softer and performed better in foldability than control tortillas after 35 days of room temperature storage and rated better in taste and tenderness than the control.ConclusionsBoth maltogenic amylases delayed staling and prolonged softness and foldability.Significance and NoveltyOverall, the high‐performing maltogenic amylase did not outperform the first‐generation maltogenic amylase at 25 and 50 ppm. However, at a higher dosage (100 ppm), the high‐performing maltogenic amylase is capable of producing overall softer tortillas with improved tenderness and taste across 35 days of storage. This research is novel as this high‐performing maltogenic amylase has not been studied by others to improve the quality of tortillas.
Identifying causative medications for agranulocytosis: A case report of an older adult with cerebral infarction
Authors: Kurokawa Yuuri , Watanabe Ayako , Kashiwabara Yuka , Fukuda Saori , Nomoto Shohei , Kuriki Ayako , Momo Kenji 
Published: January 2024

Key Clinical MessageMost drugs that cause adverse events are difficult to identify in critically ill patients undergoing polypharmacy. We share our experience in identifying the causative drug among four suspect drugs administered during emergency treatment.AbstractWe present the case of a 93‐year‐old man who was admitted for the treatment of cerebrovascular events. The patient was initially prescribed dual antiplatelet therapy with aspirin and clopidogrel along with lansoprazole, Hange‐koboku‐toh, and elobixibat. On day 36 after admission, the patient was found to have developed agranulocytosis. To improve his cerebrovascular prognosis, we first discontinued medications other than the anticoagulant medicines and initiated filgrastim. We discontinued clopidogrel 9 days after the discontinuation of the other medicines considering his low white blood cell count. One day after the discontinuation of clopidogrel, the agranulocytosis was alleviated. Considering the time course, clopidogrel, lansoprazole, Hange‐koboku‐toh, and elobixibat were suspected as the culprit medicines. This case highlights the considerable challenges encountered in clinical practice when attempting to identify the drugs responsible for agranulocytosis, particularly in patients on intensive medication therapy.
Thoracic spinal epidural hematoma misdiagnosed as conversion paralysis: A case report
Authors: Morimoto Tadatsugu , Hirata Hirohito , Nikaido Takuya , Taniguchi Kenichiro , Yoshihara Tomohito , Kobayashi Takaomi , Tsukamoto Masatsugu , Mawatari Masaaki 
Published: January 2024

Key Clinical MessageA woman with a history of psychiatric hospitalization was misdiagnosed with conversion paralysis despite lower extremity paralysis due to a thoracic epidural hematoma, leaving her with severe neurological deficits. Conversion paralysis is a diagnosis of exclusion and should never be made unless all possible organic causes have been ruled out.
An unusual case of Zieve's syndrome in a 36‐year‐old male with latent autoimmune diabetes of adult and disseminated intravascular coagulation
Authors: Zalavadiya Rushit , Bhatt Jugal Hiren , Nagori Irfan , Kagathara Nency , Neupane Srijana 
Published: January 2024

Key Clinical MessageZieve's syndrome, associated with chronic alcoholism, manifests as hemolytic anemia, transient hyperlipidemia, and cholestatic jaundice. Key symptoms comprise nausea, abdominal pain, and jaundice. Diagnosis relies on recognizing the triad in those with an alcohol use history. Supportive management includes blood transfusions and alcohol cessation. The exact pathophysiology remains uncertain, with hypotheses ranging from alcohol‐induced liver damage to autoimmune processes. The report emphasizes diagnostic complexities, particularly when concurrent with autoimmune disorders such as latent autoimmune diabetes of adults or complicated by disseminated intravascular coagulation (DIC). A 36‐year‐old male with latent autoimmune diabetes of adults and an 18‐year history of chronic alcoholism presented with yellowish skin discoloration, abdominal pain, and distension. Physical examination revealed signs of anemia, jaundice, pedal edema, hepatomegaly, splenomegaly, and abdominal tenderness. Over eight admissions, multiple tests revealed severe anemia, thrombocytopenia, elevated bilirubin, and positive autoantibodies. Treatment for suspected autoimmune hepatitis showed no improvement. Subsequent examinations indicated DIC, altered liver function, and cirrhosis progression. A confirmed diagnosis of Zieve's syndrome was made. Upper gastrointestinal endoscopy was done to check for esophageal varices which were banded. The patient was subsequently managed on supportive treatment with multiple blood transfusions and abstinence from alcohol. Prompt recognition of Zieve's syndrome is crucial to avoid unnecessary interventions. Alcohol cessation is the keystone of treatment, emphasizing the need to raise awareness among practitioners. This case points toward the importance of comprehensive evaluation, serial investigations, and multidisciplinary collaboration for accurate diagnosis and management. Further research is needed to enhance understanding and optimize therapeutic strategies.
An unusual presentation of metastatic prostate cancer in a 44‐year‐old man: A case report and review of the literature
Authors: Taheri Homa , Ebrahimi Pouya , Nazari Pedram , Kefayat Amirhosein , Mahdavian Abbas 
Published: January 2024

AbstractProstate cancer is one of the two most common non‐cutaneous cancers in men. Its presentation might be with unusual symptoms and cause the wrong initial diagnosis. This case report discusses a rare neurologic manifestation of advanced metastatic cancer in a low‐risk man. He had been receiving treatment for multiple sclerosis incorrectly due to unusual manifestations such as claudication and pelvic, leg, and shoulder pain. The patient underwent a whole‐body bone scan and then a transrectal ultrasound‐guided biopsy, which confirmed metastatic prostate cancer with a Gleason score between 7/10 and 10/10 in all samples. Following treatment with chemotherapeutic injections (docetaxel), luteinizing hormone‐releasing hormone (LHRH) analogous (Zoladex), and testosterone‐suppressing tablets (abiraterone), the disease has been under control and prostate‐specific antigen (PSA) level has decreased significantly. The most common sites of metastasis are regional lymph nodes, bones, and lungs. However, there are reports about the spread of this type of cancer to other parts of the body. Although most patients are diagnosed when the tumor is localized to the prostate, in about 25% of patients, the disease is diagnosed when metastasis has occurred. Some markers can assist physicians in the diagnosis of this disease, such as the Prostate Health Index and the 4 K score.Key Clinical MessageThe diagnosis of prostate cancer should be considered in all age ranges of adult men. The long‐distance metastasis might cause unusual presentations of the disease, such as neurologic, musculoskeletal, and dermatologic symptoms and signs far from the origin of the cancer, before genitourinary manifestations. It is crucial to keep the diagnosis of prostate cancer in mind for men with suggestive signs and symptoms that are not usually detected in this disease.
Influence of Precipitation Conditions on Properties of Ceria and their Implications on the Mars‐van‐Krevelen Active Surface Area
Authors: Florenski Jan S. , Schellander Noah , Klemm Elias 
Published: January 2024

AbstractQuantifying the active surface area of Mars‐van‐Krevelen catalysts is paramount for the elucidation of structure‐property relationships and the knowledge‐based catalyst development. Different cerium oxides were prepared via precipitation‐based techniques. By altering conditions during precipitation, materials with a wide span of material properties were prepared. The influence of temperature during ammonia‐based precipitation was investigated. When using Ce(IV) precursors an increase in precipitation temperature decreases the crystallite size while increasing specific surface area, attributed to an increase in nucleation rate. Sintering stability is also increased for materials precipitated at higher temperature. Measuring the total oxygen storage capacity (TOSC) values of the prepared materials showed that the TOSC is not strictly a function of BET surface area. Our results suggest that crystallites with a domain size under a certain threshold are not reduced via oxygen release but rather hydroxyl formation. A method was proposed with which the redox active surface area for polycrystalline ceria can be estimated on basis of the domain size obtained from Rietveld refinement. These findings were corroborated by CO oxidation light‐off experiments in which the light‐off temperature was found to correlate with the surface that can release oxygen reversibly, the Mars‐van‐Krevelen active surface area, rather than BET surface area.
Luminescent Supramolecular Ionic Frameworks based on Organic Fluorescent Polycations and Polyanionic Phosphorescent Metal Clusters
Authors: Kashnik Ilya V. , Yang Binying , Yarovoi Spartak S. , Sukhikh Taisiya S. , Cordier Marie , Taupier Grégory , Brylev Konstantin A. , Bouit Pierre‐Antoine , Molard Yann 
Published: January 2024

AbstractEmissive ionic supramolecular frameworks are designed by associating tetraphenylethylene‐based tetra‐cationic units and di‐anionic molybdenum or tetra‐anionic rhenium octahedral clusters. Obtained structures were characterized by single‐crystal X‐ray diffraction. The emission properties of the hybrids were investigated as dry powders or in various solvents by one photon and two photon absorption leading to a O2 concentration dependent luminescence color for the Mo based hybrid.
Safety and Pharmacokinetics of Quizartinib Combination Therapy With Standard Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia: Results from Two Phase 1 Trials in Japan and China
Authors: Qi Junyuan , Choi Ilseung , Ota Shuichi , Ichikawa Satoshi , Fujishima Naohito , Iida Hiroatsu , Sugiura Isamu , Sugiura Koichi , Murata Yasuharu , Inoue Hiroyuki , Ohwada Shoichi , Wang Jianxiang 
Published: January 2024

AbstractQuizartinib is a potent, oral, second‐generation, selective type II FMS‐like receptor tyrosine kinase 3 (FLT3) inhibitor. It has shown improved overall survival in a randomized, multinational, Phase 3 (QuANTUM‐First) study in patients with FLT3‐internal tandem duplication (ITD)‐positive newly diagnosed acute myeloid leukemia. We conducted 2 Phase 1b studies in Japan and China to evaluate the safety, pharmacokinetics, and efficacy of quizartinib in combination with standard induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia. Quizartinib was started at a dose level of 20 mg/day and then escalated to 40 mg/day, the dose used in the Phase 3 study. Seven patients were enrolled according to the 3 + 3 dose‐escalation method in each study, including 3 patients who were FLT3‐ITD positive. No dose‐limiting toxicities were observed at dose levels up to 40 mg/day in both studies. Grade 3 or higher, quizartinib‐related, treatment‐emergent adverse events included febrile neutropenia, hematologic toxicities, and infections. QT prolongation on electrocardiogram was observed in 5 patients. The pharmacokinetics of quizartinib and its metabolite AC886 were similar between the studies and consistent with previous findings in the United States. We confirmed the tolerability of Japanese and Chinese patients to the dose of quizartinib and chemotherapy regimens used in the QuANTUM‐First study.
Concentration‐QTcF Modeling of Icenticaftor from a Randomized, Placebo‐ and Positive‐Controlled Thorough QT Study in Healthy Participants
Authors: Iyer Ganesh R. , Darpo Borje , Xue Hongqi , Lecot Jean , Zack Julia , Bebrevska Lidiya , Weis Wendy , Jones Ieuan , Drollmann Anton 
Published: January 2024

AbstractIcenticaftor (QBW251) is a potentiator of the cystic fibrosis transmembrane receptor. Based on its mechanism of action, icenticaftor is expected to provide benefits in patients with chronic obstructive pulmonary disease by restoring mucociliary clearance, which would eventually lead to a reduction of bacterial colonization and related inflammatory cascade. A placebo‐ and positive‐controlled, 4‐way crossover thorough QT study was conducted in 46 healthy participants with the objective to assess the effect of therapeutic (300 mg twice daily for 6 days) and supratherapeutic (750 mg twice daily for 6 days) oral doses of icenticaftor on electrocardiogram parameters, including concentration‐corrected QT (QTc) analysis. Moxifloxacin (400 mg, oral) was used as a positive control. In the concentration‐QTc analysis performed on pooled data from Day 1 and Day 6 (steady state), the estimated population slope was shallow and slightly negative: –0.0012 ms/ng/mL. The effect on the Fridericia corrected QT (QTcF) interval (∆ΔQTcF) was predicted to be −1.3 milliseconds at the icenticaftor 300‐mg twice‐daily peak concentration (geometric mean was 1094 ng/mL) and −5.5 milliseconds at the 750‐mg twice‐daily peak concentration (geometric mean Cmax was 4529 ng/mL) indicated a mild shortening effect of icenticaftor on QTcF interval length. The results of the by‐time‐point analysis indicated least squares placebo corrected mean ∆∆QTcF across time points ranged from –7.9 to 0.1 milliseconds at 1 and 24 hours after dosing both on Day 6 in the 750‐mg dose group compared with –3.7 to 1.6 milliseconds at 1.5 and 24 hours after dosing on Day 1 in the 300‐mg dose group. Assay sensitivity was demonstrated with moxifloxacin. The large accumulation of exposures, especially the 4.3‐fold increase in peak plasma concentration observed at the icenticaftor 750‐mg twice‐daily dosage compared with Icenticaftor 300 mg twice daily (2.3‐fold) on Day 6 provided a large concentration range (up to 9540 ng/mL) to evaluate the effect of icenticaftor on ΔΔQTcF. Based on the concentration–QTc analysis, an effect on ΔΔQTcF exceeding 10 milliseconds can be excluded within the full observed ranges of plasma concentrations on icenticaftor, up to approximately 9540 ng/mL. Icenticaftor at the studied doses demonstrated a mild shortening in QTcF, which is unlikely to be of clinical relevance in a therapeutic setting.
MF‐DLB: Multimetric forwarding and directed acyclic graph‐based load balancing for geographic routing in FANETs
Authors: Singh Vikramjit , Sharma Krishna Pal , Verma Harsh Kumar 
Published: January 2024

SummaryFlying ad hoc network (FANET) comprising unmanned aerial vehicles (UAVs) emerges as a promising solution for numerous military and civil applications. Transferring data collected from the environment to the ground station (GS) is a primary concern for meeting the communication demands of most of these applications. However, the highly mobile UAVs with limited communication range, resulting in frequent topology change and intermittent connectivity, make data routing challenging. In such scenarios, geographic routing is a viable solution due to its scalability and robustness. However, the basic forwarding mechanism of geographic routing favors the neighboring UAV nearest to the destination, impacted substantially by link failures and routing holes in a dynamic environment. Additionally, routing decisions ignoring the current load over UAVs contribute to performance degradation due to the high concentration of data traffic near the GS. Thus, to address these issues, a geographic routing protocol named MF‐DLB comprising multimetric forwarding (MF) and a directed acyclic graph‐based load balancing (DLB) scheme is proposed to enhance packet forwarding in FANETs. MF takes account of multiple metrics related to connectivity, geographic progress, link lifetime, and residual energy to select the next hop with a stable communication link while effectively bypassing the routing holes. The second scheme, DLB, focuses on proactively maintaining routing paths near GS for load distribution among underutilized nodes to address the congestion problem. Simulations performed in network simulator ns‐3 confirm the outperformance of MF‐DLB over other related routing schemes in terms of different performance metrics.