bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser Ablation for Benign and Malignant Thyroid Nodules – A
Mini-Literature Review
Authors: Negro Roberto 
Published: October 2023

Background::
Thyroid nodules are a common disease in endocrine clinical practice.
They are often benign, asymptomatic, and do not require any treatment. But, in a non-negligible
proportion, they can cause local symptoms of compression or esthetic concerns. In the last two
decades, the advent of laser ablation (LA) has become a valid alternative to surgery for these
nodules. Moreover, LA has also been successfully used to treat small thyroid cancers and neck
recurrence.

Objective::
This study aims to review and summarize the published literature regarding LA in
the treatment of benign and malignant thyroid nodules.

Methods::
A comprehensive literature search on PubMed from 2000 to 2023 was carried out.
The search terms included: thyroid, nodules, laser, cancer, lymph node metastasis, and autonomously
functioning nodules. The most relevant investigations in the field were selected.

Results::
In the last two decades, a very remarkable number of papers consistently demonstrated
that LA is able to durably shrink benign nodules on average by about 50%; better results are
obtained in spongiform nodules with a volume less than 15 ml; 500 J/ml of tissue should be administered.
LA may be a valid option to treat autonomously functioning nodules and papillary
thyroid cancers especially if they are <10mm, and with neck recurrence in patients already submitted
to surgery. LA has also been demonstrated to be cost-effective compared to surgical
treatment both in benign and malignant lesions, with similar outcomes.

Conclusion::
Evidence demonstrated that LA is a valid alternative to surgery in benign and malignant
thyroid lesions, but also to obtain a successful treatment, a careful selection of the lesion
is mandatory.
RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling
Authors: Feng Jianguo , Long Menghong , Zhao Xin , Yan Pijun , Lin Yunxiao , Wang Maohua , Huang Wenhua 
Published: October 2023

Background:With the increasing risk of infections and other serious complications, the underlying molecular mechanism of wound healing impairment in diabetes deserves attention. Cold shock proteins (CSPs), including CIRP and RBM3 are highly expressed in the skin; however, it is unknown whether CSPs are involved in the wound-healing impairment of diabetic skin.Objective:The objective of this study is to investigate the effects of RBM3 on skin wound healing in diabetes.Methods:In vitro experiments, western blot assay was used to test the levels of proteins in HaCaT cells treated with different concentrations of glucose. RBM3 was over-expressed in HaCaT cells using lentivirus particles. Cell viability was analyzed by Cell-Counting Kit-8 assay and colony formation assay. The migration of HaCaT cells at different concentrations of glucose was evaluated by wound healing assay. In vivo experiments, the mouse model of diabetes was established by intraperitoneal injection of streptozotocin. Four weeks later, the mice were anesthetized by intraperitoneal injection of pentobarbital sodium for skin tissue collection or wound healing experiments. RBM3 knockout mice were established by removing exons 2–6 using the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technique and then used in skin wound healing experiments with or without diabetic stress.Results:In this study, the expression of RBM3, rather than CIRP, was altered in the skin of diabetic specimens, and the RBM3’s overexpression accelerated the cell viability and proliferation of HaCaT cells under high glucose conditions. RBM3 deficiency caused delayed wound healing in RBM3 knockout in diabetic conditions. Moreover. RBM3 enhanced the ERK1/2 signaling pathway, and its inhibitor FR180204 blocked the beneficial effect of RBM3 overexpression on skin wound healing in diabetes.Conclusion:RBM3 activated the ERK1/2 signal to facilitate skin wound healing in diabetes, offering a novel therapeutic target for its treatment.
Targeting FGFR3 is a Useful Therapeutic Strategy for Rheumatoid Arthritis
Treatment
Authors: Yu Shan-Fu , Cheng Tien-Tsai , Huang Gong-Kai , Hsu Chung-Yuan , Kao Ying-Hsien , Chung Yueh-Hua 
Published: October 2023

Background::
Rheumatoid arthritis (RA) is a systemic inﬂammatory disease in which TNF-α plays an important role. Fibroblast growth factor receptor 3 (FGFR3) is reportedly involved in RA by regulating expression of inﬂammatory cytokines.

Objective::
This study examined the expression profile of FGFR3 in human synovial biopsy tissues and evaluated its gene silencing effects on behaviors of synovial cells.

Methods::
Immunohistochemical staining was used to measure FGFR3 expression in human RA joint tissues. Cell proliferation, migration, and apoptosis assays were used to monitor behavioral changes in cultured synovial SW-982 cells with siRNA-mediated FGFR3 gene silencing. Immunofluorescent staining and western blotting were used to detect molecular changes in the FGFR3 gene silenced cells.

Results::
FGFR3 up-regulation was noted in both cytoplasms and nuclei of synovial cells in human RA joints. FGFR3 siRNA delivery experiments corroborated that FGFR3 knockdown decreased proliferation and migration, and triggered apoptosis of synovial cells. The FGFR3 gene knockdown enhanced constitutive expression of epithelial marker E-cadherin and conversely suppressed expression of epithelial-mesenchymal transition (EMT) markers, including Snail, fibronectin and vimentin. In addition, FGFR3 silencing significantly reduced the constitutive expressions of TNF-α, transcription factor NF-kB, and downstream COX-2 protein and collagenolytic enzyme MMP-9. MAPK inhibition markedly suppressed constitutive levels of NF-kB, COX-2 and MMP-9.

Conclusion::
Genetic interference of FGFR3 could modulate the expression of inflammatory mediators and EMT markers in the synovial cells. Targeting FGFR3/MAPK signal axis may be considered as a useful therapeutic strategy to ameliorate the development of RA.
Refinement and Usability Analysis of an eHealth App for Ankylosing Spondylitis as a Complementary Treatment to Physical Therapy: Development and Usability Study
Authors: Nitschke Marlies , Nwosu Obioma Bertrand , Grube Lara , Knitza Johannes , Seifer Ann-Kristin , Eskofier Bjoern M , Schett Georg , Morf Harriet 
Published: October 2023

Background
Mobile eHealth apps have been used as a complementary treatment to increase the quality of life of patients and provide new opportunities for the management of rheumatic diseases. Telemedicine, particularly in the areas of prevention, diagnostics, and therapy, has become an essential cornerstone in the care of patients with rheumatic diseases.

Objective
This study aims to improve the design and technology of YogiTherapy and evaluate its usability and quality.

Methods
We newly implemented the mobile eHealth app YogiTherapy with a modern design, the option to change language, and easy navigation to improve the app’s usability and quality for patients. After refinement, we evaluated the app by conducting a study with 16 patients with AS (4 female and 12 male; mean age 48.1, SD 16.8 y). We assessed the usability of YogiTherapy with a task performance test (TPT) with a think-aloud protocol and the quality with the German version of the Mobile App Rating Scale (MARS).

Results
In the TPT, the participants had to solve 6 tasks that should be performed on the app. The overall task completion rate in the TPT was high (84/96, 88% completed tasks). Filtering for videos and navigating to perform an assessment test caused the largest issues during the TPT, while registering in the app and watching a yoga video were highly intuitive. Additionally, 12 (75%) of the 16 participants completed the German version of MARS. The quality of YogiTherapy was rated with an average MARS score of 3.79 (SD 0.51) from a maximum score of 5. Furthermore, results from the MARS questionnaire demonstrated a positive evaluation regarding functionality and aesthetics.

Conclusions
The refined and tested YogiTherapy app showed promising results among most participants. In the future, the app could serve its function as a complementary treatment for patients with AS. For this purpose, surveys with a larger number of patients should still be conducted. As a substantial advancement, we made the app free and openly available on the iOS App and Google Play stores.
Impacto da transição demográfica no sistema único de saúde
Authors: Augusto Casotti Cezar 
Published: October 2023

Apesar de tardiamente, quando comparado aos países desenvolvidos, a população brasileira tem experimentado, ao longo dos últimos anos, mudanças significativas no padrão demográfico. Durante décadas, a taxa de natalidade no país foi alta, o que fez com que fossemos chamado de país do futuro, devido a expressiva participação do grupo etário das crianças frente ao dos jovens, adultos e idosos.
Contudo, a cada censo demográfico realizado no país, observa-se redução da participação do grupo das crianças, em decorrência da queda acentuada da fecundidade, e aumento do contingente populacional de idosos, em devido aumento da expectativa de vida, fruto de melhoria, mesmo que lenta, das condições sociais e econômicas...
Demand Uncertainty and the Production of Audit Services
Authors: Ayres Douglas R. , Kleppe Tyler J. , Shipman Jonathan E. , Stanfield Jason W. 
Published: October 2023

SUMMARY
Economic theory suggests that demand uncertainty should influence producer behavior. In this study, we empirically examine the impact of demand uncertainty on the production of audit services. Auditors must make resource allocation decisions in advance of exact demand being known, and because a large portion of auditors’ capacity-related commitments are fixed and therefore difficult to adjust in the short run, uncertainty in client demand outcomes likely imposes costs on auditors. Consistent with auditors being compensated for these costs, our results indicate that both audit price and audit production timing are affected by a client’s uncertainty in demand for audit services. We also find that these compensation mechanisms act as substitutes used by auditors to alleviate the costs imposed by demand uncertainty. Our study contributes to the growing literature on the underlying economics of the audit market and answers recent calls for analysis of demand-side factors that influence the audit industry.
Data Availability: Data are available from the sources cited in the text.
JEL Classifications: M40; M41; M42.
PENGARUH SUPLEMENTASI JINTEN HITAM (Nigella sativa L.) TERHADAP KONSUMSI RANSUM, PERTAMBAHAN BERAT TUBUH, KONVERSI RANSUM, DAN MORTALITAS PADA AYAM KAMPUNG JANTAN
Authors: Chania Dita , Santosa Purnama Edy , Sutrisna Rudy , Nova Khaira 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Nigella sativa L. terhadap konsumsi ransum, pertambahan berat tubuh, konversi ransum dan mortalitas pada ayam kampung jantan. Penelitian ini dilaksanakan pada Desember 2022--Februari 2023 di Laboratorium Lapang Terpadu, Fakultas Pertanian, Universitas Lampung. Penelitian ini menggunakan RAL (Rancangan Acak Lengkap) dengan empat perlakuan dan setiap perlakuan diulang tiga kali yaitu ransum tanpa Nigella sativa L. (P0), ransum + 36 mg/kg BB/hari Nigella sativa L. (P1), ransum + 72 mg/kg BB/hari Nigella sativa L. (P2), dan ransum + 144 mg/kg BB/hari Nigella sativa L. (P3). Setiap satuan percobaan terdiri dari 5 ekor ayam kampung jantan, sehingga total ayam yang digunakan yaitu 60 ekor. Peubah yang diamati yaitu konsumsi ransum, pertambahan berat tubuh, konversi ransum, dan mortalitas. Data yang diperoleh dianalisis menggunakan analisis ragam pada taraf nyata 5%. Hasil penelitian menunjukkan bahwa penambahan Nigella sativa L. tidak berpengaruh nyata (P>0, 05) terhadap konsumsi ransum, pertambahan berat tubuh, konversi ransum dan mortalitas pada ayam kampung jantan.
Ludus Regularis: The Clergy Game
Authors: Cardoso Carla 
Published: October 2023

Abstract
Ludus Regularis is a board game with dice, from the 10th century, which came to our knowledge through literary sources. The rules of the game were kept by the historian Balderic, in the 11th century, in a book edited in 1615 by Colvener: Chronicon Cameracense et Atrebatense, and reedited in 1834 by André Le Glay, in Paris: Chronique d’Arras et de Cambrai.
By studying the probabilities involved in the dynamics of the game Ludus Regularis, it is possible to advance that the author’s concerns were mainly centred on presenting a game that followed Catholic doctrine.
Ludus Regularis is a carefully conceived game, using dice commonly inaccessible to members of the clergy, in a context of deep Christian religious symbolism.
Reassessing Roman and Late Antique ‘Marbles Lanes’: One Game or Many?
Authors: Penn Tim , Courts Summer , Schädler Ulrich 
Published: October 2023

Abstract
Characterised by the presence of multiple depressions or pockets in a variety of arrangements, and, in some cases, the presence of a single, double, or triple ‘start line’ carved into horizontal stone surfaces, marble lanes in their variety of forms open a window onto ancient play that few have looked through. Thought to be a playing surface for some kind of throwing or rolling game which involved the use of glass or ceramic spheres, Roman marble lanes have received comparatively little attention in the recent upswing of scholarship on ancient play, partially as a result of the relative dearth of textual and iconographic sources discussing or depicting their usage, but these playing surfaces nevertheless represent a major corpus of ludic material. This contribution summarises past work on marble lanes before exploring the limited textual and iconographic source material related to playing with marbles. It offers a tentative new typology by which to categorise marble lanes and a non-exhaustive list of these playing surfaces recorded at archaeological sites around the Mediterranean. It then moves onto a discussion of the game/games that may be played on these boards, arguing that the wide variations in the different layouts for marble lanes may indicate that they were used not for one tightly-defined game, but more likely facilitated the playing of a loosely connected family of games, with implicaitons for how we think about communities of play in the past.
Economically optimised target state of uneven-aged forest management for main forest types in Slovakia
Authors: Roessiger Joerg , Kulla Ladislav , Murgaš Vlastimil , Sedliak Maroš , Šebeň Vladimír 
Published: October 2023

Abstract
The study presented a bioeconomic modelling approach for an uneven-aged mixed forest management planning. Regression models for transition (increment), and ingrowth (regeneration) used the National Forest Inventory (NFI) of Slovakia and regional inventory data. Mortality was based on salvage logging records. Models were specific for five tree species within three forest types (FT) (oak with hornbeam and beech, beech, mixed fir-beech-spruce). Net timber prices were calculated with regard to stem quality. Tree growth depended on crown characteristics. The regression models were adjusted to three main geobiotope (GBT) sites per FT. Forest growth was simulated with the density-dependent stand-level matrix transition model. Financial optimisation of harvest was sensitive to an interest rate. Long-time optimisation stabilised in a steady state equilibrium characterised by a stable diameter distribution. Target diameters were specific for site and tree species, and were highest for fir, a dense crown, a good stem quality, and a lower interest rate. Standing timber volume varied from 150 m3 ha–1 (oak forests, 2% interest rate) to 400 m3 ha–1 (beech and fir-beech-spruce forests, 0.5% interest rate). Harvested volume varied from 38 to 93 m3 ha–1 per 10 years, stand basal area (ba) varied from 19 to 36 m2 ha–1 depending on the site, timber price, and interest rate. The discussion pointed out that the relative low volume of the oak FT resulted from the light-demanding characteristics of oak. The mean of oak mosaic structures was lower compared to the high level of more storeys present in the single tree selection structures in beech and mixed fir-beech-spruce forests.
Factors Influencing Scabies Infection at the Al-Amin Islamic Boarding School in Sukabumi
Authors: Adinata Thariq Mahathir , Sulistiyaningrum Sri Katon , Saenong Rizqa Haerani , Marindawati Mieke 
Published: October 2023

Background: Scabies are a common health problem in many countries, mainly in densely populated areas. The prevalence of scabies in first community health services in Indonesia is 5.6-12.9%. Scabies infection is associated with a lack of health education, small bedrooms with too many people living in poor sanitation, and a crowded environment found in public Islamic boarding schools in Indonesia. Purposes: To investigate the correlation between characteristics, knowledge, and hygiene behavior with the incidence of scabies among boarding school students. Methods: This is a cross-sectional analytic study; 150 subjects were conducted in this study, and eight subjects were excluded. Subjects were conducted for an examination and filled out a questionnaire to diagnose the scabies infection. Bivariate and multivariate logistic regression analyses were used to assess the risk factors of subjects associated with scabies infection. Results: 142 subjects were analyzed, and 77 (54.2%) were diagnosed with scabies. From bivariate analyses, we found that gender (p<0.0001), level of education (p<0.0001), and clean behavior (p<0.0001) were associated with scabies outcome. Male (p=0.015, OR 95% CI 4.3 (1.3 – 14.3), higher level of education (p=0.012, OR 95% CI 8 (1.58 – 41.2), and poor hygiene behavior (p<0.0001, OR 95% CI 1 (1.02 – 1.09) were independently associated with scabies infection. Conclusions: There was a significant association between gender, level of education, and clean behavior with scabies outcome. Males, low levels of education, and poor hygiene behavior increase the incidence of scabies infection. Age, nutritional status, and knowledge of scabies were not associated with scabies outcome.
Late Antique Domus of Via Dogana in Faenza: The Vestibulum Mosaic. Completion of the Restoration Work, New Methods for Conservation and Enhancement
Authors: FRANZONI Agnese , SAGRIPANTI Elena , PERPIGNANI Paola , MACCHIAROLA Michele , ZAMBRUNO Simone 
Published: October 2023

This paper describes the multidisciplinary study and the completion of the restoration work conducted on an important floor mosaic from the fifth century AD. The floor, a big polychrome and figured mosaic, was discovered in the 1970s in the city center of Faenza and belonged to the vestibulum of a late antique domus.
An effective collaboration between the Parco Archeologico di Classe - RavennAntica Foundation and the University of Bologna Master Degree in Conservation and Restoration has allowed to experiment, test, and improve some methodologies concerning mosaic restoration and enhancement.
Specifically, some experimental studies regarding the use of lime mortars were carried out, in order to reintegrate the small gaps in the mosaic. Furthermore, in addition to a three-dimensional relief of the whole floor, some virtual integration proposals were created. At the same time, some information panels were proposed to integrate the museum project.
The restoration was thus a moment of study and active experimentation, that did not neglect the enhancement of such a significant artistic testimony.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL, SELF EFFICACY, DAN WORK ENGAGEMENT TERHADAP PERILAKU KERJA INOVATIF YANG DIMODERASI OLEH LINGKUNGAN KERJA PADA PEGAWAI
Authors: Made Febrie Arisandi Alangkajeng Ni , Asmony Thatok , Saufi Akhmad 
Published: October 2023

Innovative work behavior can result in constructive conflict, innovation success, and a positive work attitude. Also there is an increase in performance, compatibility between demands and work abilities, job satisfaction, employee welfare, better interpersonal relationships, and increased personal growth. The purpose of this study was to determine the effect of transformational leadership, self-efficacy, and work engagement on innovative work behavior. The sample in this study amounted to 65 samples. The instrument used in this research is a questionnaire. Data were analyzed using Structural Equation Modeling with the help of the Partial Least Square (PLS) program. Based on the results of the study, it can be concluded that transformational leadership, self-efficacy, and work engagement have a positive and significant effect on the innovative work behavior of employees of the West Nusa Tenggara Province Communication, Informatics and Statistics Office. The work environment is able to moderate the relationship between transformational leadership on innovative work behavior of employees of the Information Communication and Statistics Office of the Province of West Nusa Tenggara, while others say that the work environment has not been able to moderate the relationship between self-efficacy and work engagement towards innovative work behavior of employees of the Office of Information Communication and Statistics of the Province of West Nusa Tenggara.
Keywords:
Transformational Leadership, Self Efficacy, Work Engagement, Innovative Work Behavior, and Work Environment
TECNOLOGIA DIGITAL APLICADA NO PROCESSO DE ENFERMAGEM
Authors: NUNES SEIDEL EDUARDA , VALÉRIA ROSA LIMA MÁRCIA , SOARES SEIDEL THIAGO , RAMOS ALMEIDA ERIC GUSTAVO , PIRES IVO DE QUEIROZ GESIANE , VIEIRA ALMEIDA ANA LÍLIA 
Published: October 2023

Introdução: A tecnologia em saúde cada vez mais auxilia os processos de enfermagem otimizando tempo e facilitando ações. Objetivo: Desenvolver um software protótipo a ser utilizado durante o Processo de Enfermagem no auxílio da consulta de Diagnósticos de Enfermagem. Método: Trata-se de um estudo descritivo quase experimental com abordagem quali-quantitativa. Produzido em quatro etapas: levantamento bibliográfico, desenvolvimento do software, teste do software e avaliação do software. O desenvolvimento do software foi feito por um profissional de Tecnologia da Informação, a patir de entrevista com dez estudantes do último período do curso de Enfermagem em uma Universidade Federal do Estado do Rio de Janeiro. O trabalho foi aprovado pelo Comitê de Ética em Pesquisa sob o CAEE 30116320.2.0000.5243. Resultado: A entrevista realizada, permitiu o desenvolvimento de um o software para ser utilizado na consulta dos Diagnósticos de Enfermagem de acordo com a taxonomia NANDA-I, durante a aplicação do Processo de Enfermagem. O protótipo obteve a avaliação positiva por parte dos participantes do estudo. Conclusão: Constatou-se a otimização do tempo como vantagem que pode ser convertido em melhora na qualidade da assistência.