bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It's Like You're Feeding Your Child Twice”: Barriers and Facilitators to Human Milk Feeding Children With Cystic Fibrosis
Authors: Colborg Adrianne , Smith Brandon M. , Green Deanna M. , Nasr Samya , Sawicki Gregory S. , Schechter Michael S. , Riekert Kristin A. , Dickinson Kimberly M. 
Published: January 2025

ABSTRACTBackgroundCystic Fibrosis Foundation guidelines recommend human milk (HM) as the ideal source of nutrition for children with CF (cwCF). Despite known pulmonary and nutritional benefits, fewer cwCF ever receive HM compared to the general population. Early nutrition choices are preference‐sensitive, yet little is known about the factors that impede or sustain HM feeding among parents of cwCF.ObjectivesExplore perceptions and experiences of mothers of cwCF who initiated HM feeding.MethodsMothers of cwCF aged ≤ 10 years completed audio‐taped, semi‐structured interviews describing their experiences with HM feeding. Interviews were transcribed and two researchers independently coded the transcripts and conducted content and thematic analysis using an inductive approach.ResultsParticipants included 28 mothers who initiated HM feeding. Major themes included: (1) the impact of a CF diagnosis on HM feeding plans; (2) CF‐specific challenges to HM feeding; (3) mixed perceptions of the CF care team's support for HM feeding and of the role of formula in CF nutritional care; and (4) the benefit of lactation consultants as part of the CF care team.ConclusionMany parents prioritize HM for their cwCF given the well‐established health benefits. However, CF‐specific barriers to HM feeding are common and nutritional challenges necessitating fortification add additional barriers to sustained HM feeding efforts. While HM may improve long‐term pulmonary outcomes, our findings demonstrate the need for personalized support for mothers desiring to HM feed to facilitate shared decision‐making around options to optimize early nutritional status among cwCF.
Hollow Mo Doped CoS2 Polyhedron Derived from Polyoxometalate‐based Metal‐Organic Frameworks for Efficient Overall Water Splitting
Authors: Zhang Jingwen , He Zeyang , Fu Hao , Kong Wei , Senin Petr , Proskurin Arkadii , Bian Ting , Yan Shitan 
Published: January 2025

AbstractNowadays, the sluggish hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) kinetics are the key obstacles limiting the commercial application of water splitting. In this study, a size‐matching strategy is proposed to construct the molybdenum‐doped CoS2 polyhedra (Mo‐CoS2) by encapsulating polyoxometalate (POM, H3PMo12O40) guests into mesoporous zeolite imidazolium framework‐67 (ZIF‐67), with thioacetamide (TAA) serving as a gentle sulfur source. The catalyst exhibits a pronounced hollow structure due to the synergistic etching effects of POM and TAA, which can increase the number of active sites. Additionally, the incorporation of Mo optimizes the electronic structure, thereby improving both HER and OER performance. In alkaline electrolytes, Mo‐CoS2 delivers an overpotential of 330 mV and 269 mV for OER and HER, respectively, to produce a current density of 100 mA cm−2. Moreover, Mo‐CoS2 demonstrates exceptional performance in overall water splitting, achieving a cell voltage of 1.55 V at 10 mA cm−2, along with outstanding long‐term stability. This study provides a promising avenue for the structural and component optimization of cobalt sulfide, which could significantly improve the efficiency of hydrogen production.
Enhancement of Solubility and Bioactivity of Zonisamide Through Supramolecular Inclusion With β‐Cyclodextrin: A Comprehensive Analytical and Computational Study
Authors: Baul Koushik , Roy Niloy , Deb Sibasish , Choudhury Subhankar , Ghosh Biswajit , Roy Debadrita , Karmakar Biswanath , Sarkar Mahima Misti , Roy Swarnendu , Roy Mahendra Nath 
Published: January 2025

AbstractThis study delved into the interaction between the neurological drug zonisamide (ZNS) and β‐cyclodextrin (β‐CD) using an innovative coprecipitation technique, leading to the formation of a stable 1:1 supramolecular inclusion complex (IC). Analytical tools, including 1H NMR, FTIR spectroscopy, ESIMS, UV–vis spectroscopy, and SEM, revealed the structural details of this assembly. Job's plot confirmed the stoichiometric ratio, whereas binding constants were determined through UV–vis spectroscopic titrations using the Benesi–Hildebrand method. ESIMS data corroborated these findings. Molecular modeling and density functional theory (DFT) calculations provided additional evidence of complexation, demonstrating the stability of the IC through adsorption energy analysis. Biological evaluations showed enhanced antioxidant and antimicrobial activities of the ZNS+β‐CD complex compared to pure ZNS, reflecting its improved properties. Encapsulation within β‐CD significantly increased the solubility of ZNS in aqueous media, enabling lower effective dosages and reducing potential side effects. The study's experimental and computational findings aligned seamlessly, affirming the encapsulation of ZNS within β‐CD and advancing our understanding of supramolecular chemistry. This work highlights the potential of β‐CD to optimize drug solubility and therapeutic efficiency, offering a promising approach for improved drug delivery systems.
Hybrid Plasmonic Symmetry‐Protected Bound state in the Continuum Entering the Zeptomolar Biodetection Range
Authors: Clabassi Elena , Balestra Gianluca , Siciliano Giulia , Polimeno Laura , Tarantini Iolena , Primiceri Elisabetta , Tobaldi David Maria , Cuscunà Massimo , Quaranta Fabio , Passaseo Adriana , Rainer Alberto , Romano Silvia , Zito Gianluigi , Gigli Giuseppe , Tasco Vittorianna , Esposito Marco 
Published: January 2025

AbstractPhotonics bound states in the continuum (BICs) are peculiar localized states in the continuum of free‐space waves, unaffected by far‐field radiation loss. Although plasmonic nano‐antennas squeeze the optical field to nanoscale volumes, engineering the emergence of quasi‐BICs with plasmonic hotspots remains challenging. Here, the origin of symmetry‐protected (SP) quasi‐BICs in a 2D system of silver‐filled dimers, quasi‐embedded in a high‐index dielectric waveguide, is investigated through the strong coupling between photonic and plasmonic modes. By tailoring the hybridizing plasmonic/photonic fractions, a trade‐off is selected at which the quasi‐BIC exhibits both high intrinsic Q‐factor and strong near‐field enhancement because of dimer‐gap hotspot activation. Not only radiation loss is damped but in a configuration sustaining a lattice of plasmonic hotspots. This leads to an advantageous small modal volume for enhancing light‐matter interaction. The layout of nearly embedded dimers is designed to maximize the spatial overlap between the optical field and the target molecules, enhancing reactive sensing efficiency. The architecture is evaluated for its ability to detect transactive response DNA‐binding protein 43. The refractometric sensitivity outperforms current label‐free biosensing platforms, reaching the zeptomolar range. The approach highlights the potential of combining plasmonic and dielectric nanomaterials for advanced sensing technologies.
Centering Empathy Through Embodied Experiential Learning in Teacher Education
Authors: Moreno Rhia 
Published: January 2025

ABSTRACTDeveloping empathy in teacher education is essential as it contributes to increased sensitivity and understanding between teachers and their students. This is especially important for preservice content‐area teachers (PCTs) who may have limited linguistic awareness yet will be potentially teaching emergent multilinguals in their mainstream classrooms. In response, this inquiry explored the role of a simulated language learning experience (SLLE) as an embodied approach to center empathy in PCT training. Framed by Dewey's theory of experience, it used a qualitative composite narrative approach to explore PCTs' felt experiences and empathetic development through embodiment. Findings showed that emotional intensity appeared to be the strongest factor in producing empathetic reactions followed by disengagement due to lack of understanding. In contrast to similar research, participants continued to experience intense emotional and physical responses to the lesson even when supported by TESOL strategies. The embodied experience provides a pedagogical example for building empathy while also presenting implications for increased reflection to avoid false empathy.
Newtonian heating effects on Casson nanofluid flow at lower stagnation point of a solid sphere
Authors: Rafique Khuram , Khan Ilyas , Bakouri Mohsen 
Published: January 2025

AbstractIn view of the energy crises, the heat transfer of sodium alginate Casson nanoliquid flow on a lower stagnation point of the sphere is examined in this research. Three types of nanoparticles including Silver (Ag), Titanium oxide (TiO2), and Graphite oxide (GO) Sodium alginate‐based nanoliquid are taken in account for this investigation. Furthermore, magnetic field and Newtonian heating effects are incorporated. The PDEs (flow equations) are converted into ordinary differential equations (ODEs) using nondimensional similarity transformations. Additionally, a well‐known technique known as the Keller box approach is used for numerical solutions. The numerical results are produced in tabulated and graphical form versus the various involved parameters. Furthermore, findings showed that nanoliquid based on graphite oxide has the maximum velocity in view of other nanoparticles (Sodium alginate‐based nanoliquid). Moreover, the variation in magnetic effects decreases the velocity of the nanoliquid flow.
Spectral relaxation method to investigate novel ternary hybrid Carreau nanofluid model with permeable stenosed artery
Authors: Akhtar Yasmeen , Ahmad Shabbir , Khalid Fareeha , Junjua Moin‐ud‐Din , Aryanfar Yashar , Hendy Ahmed S , El‐Rahman Magda Abd , Hussain Syed Modassir 
Published: January 2025

AbstractThe exploration of blood‐based ternary nanofluid flow (Au, TiO₂, Ag) through a permeable stenosed artery with a spatially dependent heat sink source is pivotal for advancing biomedical and engineering innovations such as hyperthermia treatments, drug delivery systems, external cooling simulations, thermal ablation, and targeted therapies. This study focuses on the thermal and flow dynamics of a novel ternary nanofluid comprising Au, TiO₂, and Ag nanoparticles, modeled as Carreau fluid within the geometry of a permeable stenosed artery. The effects of magnetization and spatial heat sink sources are analyzed to investigate velocity and temperature profiles. A temperature‐dependent thermal conductivity model is employed to better understand heat transport in stenosed arteries. The spectral relaxation method (SRM) is utilized to derive numerical solutions, validated against the well‐established bvp4c numerical scheme. Among the nanoparticles studied, Au demonstrates the highest enhancement in heat transport due to its superior thermal conductivity. Notably, for increasing thermal radiation parameter values (0.72, 1.2, 1.5, 1.7), heat transport improves by 9%, 7%, 9%, and 6%, respectively.
Inter-, Cross-, and Transdisciplinarity
Authors: Hayden-Nygren Juliana , Poto Margherita Paola , Kuhn Annegret 
Published: January 2025

Abstract
The research developed within this Toolkit stems from an inter-, trans-, and cross-disciplinary collaboration including marine sciences, climate and ocean governance, ocean policy, marine ecology, marine socio-ecology, planetary health, and transdisciplinary science. This chapter explores the definitions and applications of inter-, trans-, and cross-disciplinary approaches within the context of ocean literacy research and education. The primary objective of this exploration is to develop a learning activity for young people that integrates inter-, cross-, and transdisciplinarity into ocean literacy education. The overall aim of this Toolkit chapter is to advance ocean literacy’s role in ocean protection and sustainability efforts through inter-, cross-, and transdisciplinary approaches to research and education.
Introduction to the Book
Authors: Myklebust Thor , Stålhane Tor , Vatn Dorthea Mathilde Kristin 
Published: January 2025

Abstract
AI systems are becoming vital in many industries, including safety-critical domains, and are expected to become more complex. This book introduces the AI Act (REGULATION (EU) 2024/1689) and its impact on high risk systems, providing a foundation for safety plans. It targets experts, stakeholders, manufacturers, operators, start-ups, and SMEs.
The book focuses on functional safety including automotive, railway, and seaborne systems, covering key aspects for safety plan development, including technical, human, and organizational factors. In the introduction of the book topics covering the AI Act’s risk levels, stakeholder obligations, standards, agile methods, and the role of the Agile Safety Plan in creating safety cases are presented.
Definition of the System, Operational Design Domain, and Concept of Operation
Authors: Myklebust Thor , Stålhane Tor , Vatn Dorthea Mathilde Kristin 
Published: January 2025

Abstract
This chapter consists of three section outlining how a description of a safety-critical system should be provided. First, we elaborate on how the Definition of the System (DoS) should be provided, ensuring a detailed description of the system for which the safety case is being presented. Next, we elaborate on how the environment surrounding the safety-critical system should be accounted for through a detailed description of the Operational Design Domain (ODD). Lastly, we outline how the Concept of Operation (ConOps) bridges the description made of the DoS and the ODD by addressing the different types of users and modes of operation of the system. By taking all these three aspects into account, a comprehensive description of the safety-critical system in its operational use should be accounted for.
Diskussion
Authors: Lammers Klara 
Published: January 2025

Zusammenfassung
Die Struktur der Diskussionskapitel orientiert sich an der Hypothese, dass die hier rekonstruierten Peer-Beziehungen als eine spezifische Form von Unterstützungsbeziehungen verstanden werden können. Ausgehend von dieser Annahme werden zunächst auf einer allgemeineren Ebene Abgrenzungen und Überschneidungen zu professionalisierten und verberuflichten Unterstützungsbeziehungen herausgearbeitet. Daran anschließend werden drei Bereiche, die auf Basis der empirischen Erkenntnisse als besonders relevant erachtet werden, vertieft betrachtet.
Left neck and right biceps muscle vibrations have similar effects on perceived body orientation
Authors: Stammler Britta , Karnath Hans-Otto 
Published: January 2025

Abstract
Vibrating muscles to manipulate proprioceptive input creates the sensation of an apparent change in body position. This study investigates whether vibrating the right biceps muscle has similar effects as vibrating the left posterior neck muscles. Based on previous observations, we hypothesized that both types of muscle vibration would shift the perception of healthy subjects’ subjective straight-ahead (SSA) orientation in the horizontal plane to the left. Such a finding would be extremely interesting for future treatment of spatial neglect, a disorder following right-sided stroke brain lesions. Twenty healthy participants (11 females, 9 males, aged 20–52) were tested under five conditions: baseline (no vibration), vibration of left neck muscles, vibration of right biceps with the arm fixed to the wall, vibration of right biceps with the arm lying on a table, and vibration of right triceps with the arm fixed to the wall. Participants had to align a laser pointer (by verbal instructions) with their perceived SSA position in complete darkness. ANOVA revealed significant SSA shifts with neck and biceps vibrations but not with triceps vibration. The largest leftward SSA shift occurred with right biceps vibration while the arm was lying on the table (-6.1°), followed by left neck muscle vibration (-6.0°), and right biceps vibration with the arm fixed to the wall (-5.4°). Post-hoc power analyses showed high power (> 0.98) for the significant differences compared to the baseline condition. The finding that right biceps vibration affects SSA perception similarly to left neck muscle vibration offers potential for clinical applications in treating spatial neglect. Future research should explore the therapeutic efficacy of vibrating the right biceps in neurological patients with spatial neglect.
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases
Authors: Atanasova Konstantina , Knödler Laura-Louise , Reindl Wolfgang , Ebert Matthias Philip , Thomann Anne Kerstin 
Published: January 2025

Abstract
The brain-gut axis constitutes the basis for the bidirectional communication between the central nervous system and the gastrointestinal tract driven by neural, hormonal, metabolic, immunological, and microbial signals. Alterations in the gut microbiome composition as observed in inflammatory bowel diseases can modulate brain function and emerging empirical evidence has indicated that interactions among the brain-gut microbiome-axis seem to play a significant role in the pathogenesis of both inflammatory bowel diseases and psychiatric disorders and their comorbidity. Yet, the immunological and molecular mechanisms underlying the co-occurrence of inflammatory bowel diseases and psychological symptoms are still poorly understood. The aim of this narrative review is to highlight contemporary empirical findings supporting a pivotal role of the gut microbiome in the pathophysiology of highly prevalent neuropsychiatric symptoms in inflammatory bowel diseases such as fatigue, depression, and anxiety. Finally, we focus on microbiome modulation as potential treatment option for comorbid neuropsychiatric symptoms in immune-mediated diseases and especially in inflammatory bowel diseases. High-quality clinical trials are required to clarify how microbiome modulation through dietary interventions or probiotic, prebiotic or synbiotic treatment can be used clinically to improve mental health and thus quality of life of patients with inflammatory bowel diseases.
Determining the QRS axis: visual estimation is equal to calculation
Authors: Mueller-Leisse Johanna , Syrbius Giulia , Hillmann Henrike Aenne Katrin , Eiringhaus Joerg , Hohmann Stephan , Zormpas Christos , Karfoul Nizar , Duncker David , Veltmann Christian 
Published: January 2025

Abstract

Background
The QRS axis of the electrocardiogram (ECG) is often considered in clinical practice, but its determination is frequently limited to a rough estimation, such as “normal”, with left or right deviation, and superior or inferior in the case of premature ventricular complexes (PVCs). However, a more exact determination of the QRS axis may be warranted in certain scenarios, such as to determine the origin of PVCs more precisely, and is attainable by visual estimation using the hexaxial reference system.

Objectives
The aim of this study was to determine how well such an estimation of the QRS axis would correlate with the axis calculated by formulas.

Materials and methods
A PVC database from 2012–2020 was used to extract 12-lead ECGs of patients with outflow tract PVCs and analyze the QRS axes of regularly conducted beats as well as PVCs. QRS axes were determined visually by two physicians with the help of the hexaxial reference system to an accuracy of 10° on the one hand, and were calculated using three previously described formulas based on QRS voltages on the other.

Results
A total of 216 QRS complexes from 108 patients were analyzed (108 regularly conducted beats and 108 PVCs). Estimated QRS axes of regularly conducted beats and PVCs were 39 ± 40° and 88 ± 15°, respectively. Calculated QRS axes of regularly conducted beats according to the three formulas were 37 ± 40°, 36 ± 40° and 35 ± 38°, respectively. Calculated QRS axes of PVCs according to the three formulas were 87 ± 15°, 87 ± 14° and 86 ± 16°, respectively. Correlation coefficients showed strong correlations between the estimated and the three calculated values for regularly conducted beats (0.98, 0.97 and 0.98) and PVCs (0.94, 0.94 and 0.94).

Conclusions
A sophisticated visual estimation of the QRS axis correlates well with voltage-based calculations and can therefore be considered sufficient for most purposes.
Using artificial intelligence to evaluate adherence to best practices in one anastomosis gastric bypass: first steps in a real-world setting
Authors: Dayan Danit , Nizri Eran , Keidar Andrei 
Published: January 2025

Abstract

Background
Safety in one anastomosis gastric bypass (OAGB) is judged by outcomes, but it seems reasonable to utilize best practices for safety, whose performance can be evaluated and therefore improved. We aimed to test an artificial intelligence-based model in real world for the evaluation of adherence to best practices in OAGB.Please check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary.OK

Methods
A retrospective single-center study of 89 consecutive OAGB videos was captured and analyzed by an artificial intelligence platform (10/2020-12/2023). The platform currently provides assessment of four elements, including bougie insertion, full division of pouch, view of Treitz ligament, and leak test performed. Two bariatric surgeons viewed all videos, categorizing these elements into Yes/No adherence. Intra-rater and inter-rater agreements were computed. The estimates found in greatest consensus were used to determine the model’s performance. Clinical data retrieval was performed.

Results
Videos included primary (71.9%) and conversion (28.1%) OAGB. Patients’ age was 41.5 ± 13.6y and body mass index 42.0 ± 5.7 kg/m2. Anastomosis width was 40 mm (IQR, 30–45), and biliopancreatic limb length was 200 cm (IQR, 180–200). Operative duration was 69.1 min (IQR 55.3–97.4), mainly spent on gastric transection (26%) and anastomosis (45%). Surgeons’ intra-rater overall agreements ranged 93–100% (kappa 0.57–1). Inter-rater overall agreements increased to 99–100% (kappa 0.95–1) in the second review, set as reference point to the model. The model’s overall accuracy ranged 82–98%, sensitivity 91–94%, and positive predictive value 88–99%. Specificity ranged 17–92% and negative predictive value 20–68%.

Conclusion
The model appears to have high accuracy, sensitivity, and positive predictive value for evaluating adherence to best practices for safety in OAGB. Considering the paucity of negative estimates in our study, more low-performance cases are needed to reliably define the model’s specificity and negative predictive value. Adding more best practices, tested in multi-center studies will enable cross-border standardization of the procedure.