bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Developments and Future Perspectives of Purine Derivatives as a
Promising Scaffold in Drug Discovery
Authors: Rana Neha , Grover Parul , Singh Hridayanand 
Published: January 2024

Abstract:
Numerous purine-containing compounds have undergone extensive investigation for
their medical efficacy across various diseases. The swift progress in purine-based medicinal chemistry
has brought to light the therapeutic capabilities of purine-derived compounds in addressing
challenging medical conditions. Defined by a heterocyclic ring comprising a pyrimidine ring
linked with an imidazole ring, purine exhibits a diverse array of therapeutic attributes. This review
systematically addresses the multifaceted potential of purine derivatives in combating various diseases,
including their roles as anticancer agents, antiviral compounds (anti-herpes, anti-HIV, and
anti-influenzae), autoimmune and anti-inflammatory agents, antihyperuricemic and anti-gout solutions,
antimicrobial agents, antitubercular compounds, anti-leishmanial agents, and anticonvulsants.
Emphasis is placed on the remarkable progress made in developing purine-based compounds,
elucidating their significant target sites.

:
The article provides a comprehensive exploration of developments in both natural and synthetic
purines, offering insights into their role in managing a diverse range of illnesses. Additionally, the
discussion delves into the structure-activity relationships and biological activities of the most
promising purine molecules. The intriguing capabilities revealed by these purine-based scaffolds
unequivocally position them at the forefront of drug candidate development. As such, this review
holds potential significance for researchers actively involved in synthesizing purine-based drug
candidates, providing a roadmap for the continued advancement of this promising field.
The Mushroom Albatrellus confluens: A Minireview on Phytochemistry,
Biosynthesis, Synthesis and Pharmacological Activities
Authors: Van Chu Anh , Son Ninh The 
Published: January 2024

Background:
Albatrellus confluens is one of the representative species in the Polyporaceae
family. Its major mero terpenoid grifolin and related compounds have the potential for drug
applications.

Objective:
The current study aims to briefly provide an insightful view of the phytochemistry,
biosynthesis, synthesis, and pharmacology of A. confluens metabolites.

Methods:
Data collection was performed using electronic resources, e.g., Google Scholar,
PubMed, and Sci-Finder from the 1990s to the present, while Albatrellus confluens is the most
meaningful keyword in the search for publications. The Latin name Albatrellus confluens (Alb. &
Schwein.) Kotl. & Pouzar is in accordance with the name listing on www.mycobank.org.

Results:
By chromatography column procedures, it indicated that A. confluens species was associated
with the presence of 57 secondary metabolites, in which nitrogenous compounds, meroterpenoids,
polyene pyrones, and polyesters can be seen as the main phytochemical classes. L-isoleucine
was the parent molecule in biosynthetic and synthetic steps of A. confluens nitrogenous
compounds. Numerous experiments revealed that A. confluens isolated compounds have a variety
of pharmacological activities, such as anticancer, anti-inflammatory, vasorelaxant, and neuroprotective
and skin whitening activities. Some isolates become potential cancer inhibitors. Grifolin induced
apoptosis and promoted cell cycle arrest in A2780 ovarian cancer cells via the inactivation
of the ERK1/2/Akt signaling pathway. Grifolic acid caused osteosarcoma cancer cell deaths by inhibiting
NADH generation and ATP production without obvious toxicity. Neoalbaconol caused
apoptosis and necroptosis in mice bearing nasopharyngeal C666-1 cancer cells via PDK1-
PI3K/Akt signaling inhibition.

Conclusion:
The continuation of chromatographic separation and biomedical research is expected.
Modern biological assays for explaining the pharmacological values of A. confluens constituents
are warranted. Toxicological and pharmacokinetic assessments are urgently needed.
Hyperparathyroidism and Peripheral Arterial Disease
Authors: Antignani Pier Luigi , Jezovnik Mateja K , Blinc Ales , Mikhailidis Dimitri P. , Anagnostis Panagiotis , Schernthaner Gerit-Holger , Jensterle Mojca , Studen Katica Bajuk , Sabovic Miso , Poredos Pavel 
Published: January 2024

Abstract:
Primary hyperparathyroidism (PHPT) is presented in various forms, including classic
PHPT, characterised by increased parathyroid hormone (PTH) secretion, normohormonal PHPT, and
normocalcaemic PHPT. Secondary hyperparathyroidism is characterised by increased PTH secretion
triggered by factors such as vitamin D deficiency and kidney failure. This review aims to discuss the
involvement of hyperparathyroidism (HPT) in atherosclerosis, including peripheral arterial disease
(PAD).

:
The increased level of PTH is involved in developing subclinical and overt vascular diseases, encompassing
endothelial dysfunction, vascular stiffness, hypertension, and coronary and peripheral
arterial diseases. It has been consistently associated with an augmented risk of cardiovascular morbidity
and mortality, independent of classical risk factors for atherosclerosis. Chronic hypercalcemia
associated with increased levels of PTH contributes to the development of calcification of vessel
walls and atherosclerotic plaques. Vascular calcification can occur in the intima or media of the arterial
wall and is associated with stiffness of peripheral arteries, which the formation of atherosclerotic
plaques and narrowing of the vessel lumen can follow. For treating hyperparathyroidism, particularly
SHPT, calcimimetics, novel phosphorus binders and novel vitamin D receptor activators are used.
However, they are ineffective in severe PHPT. Therefore, parathyroidectomy remains the primary
therapeutic option of PHPT.
Chronic Thromboembolic Pulmonary Hypertension
Authors: Buck Emory , Kearns Sean , Dahhan Talal , Parikh Kishan S. , Krasuski Richard A. , Rajagopal Sudarshan 
Published: January 2024

:
While the majority of patients have complete resolution of their acute pulmonary embolism
(PE) after an adequate course of anticoagulation, some patients remain symptomatic with
evidence of chronic PE. Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Chronic
Thromboembolic Pulmonary Disease (CTEPD) are terms that describe symptomatic patients
with chronic thromboembolic occlusions of the pulmonary arteries with or without pulmonary hypertension,
respectively. Here, we review the definitions, epidemiology, pathobiology, diagnosis
and management of CTEPH. The chronic PE in CTEPH is essentially a scar in the pulmonary vasculature
and is accompanied by a pulmonary arteriolar vasculopathy. Ventilation-perfusion scanning
is the most sensitive screening test for CTEPH, and diagnosis must be confirmed by right
heart catheterization (RHC). Treatment decisions require a multidisciplinary team and guidance
from additional imaging, usually CT or pulmonary angiography. While pulmonary endarterectomy
(PEA) to remove the chronic PE surgically is still the first-line treatment for appropriate candidates,
there is an expanding role for balloon pulmonary angioplasty (BPA) and medical treatment,
as well as multimodality treatment approaches that incorporate all of those options. New imaging
modalities and treatment strategies hold the promise to improve our care and management of
CTEPH patients in the future.
The Association of the Mode of Delivery and Maternal Postpartum Readmission: A Systematic Review and Meta-analysis
Authors: Maleki Azam , Youseflu Samaneh , Molaei Behnaz , Jenabi Ensiyeh , AsghariJafarabadi Mohammad 
Published: January 2024

Background:
Postpartum readmission is one of the metrics for assessing the quality of
health services. There is inconsistent evidence about postpartum readmission and complications
by mode of delivery.

Objective:
We applied a meta-analysis to investigate whether the mode of delivery is associated
with postpartum readmission or complications.

Methods:
We systematically searched main English databases for studies published up to June
2022. The Newcastle–Ottawa scale (NOS) was used to assess the quality of observational studies.
The heterogeneity of included studies was determined using the I2 statistic and Begg’s and Egger’s
tests for publication bias, respectively. Results of the random-effects meta-analysis were presented
using odds ratio (OR) estimates with 95% confidence intervals (CI). The Stata software version
16 was used for data analysis

Results:
In total, 18 studies with 514,577 subjects were suitable for reviewing maternal postpartum
readmission by mode of delivery. Our findings show that cesarean delivery is a risk factor for
increasing postpartum readmission than the vaginal delivery method (overall OR =1.42, CI 95%
1.22, 1.63, I2= 99.7%, p = 0.001). This chance was increased in primary cesarean (OR=2). Postpartum
hemorrhage and breast infection did not have risk factors for postpartum readmission.
While cardiopulmonary condition, deep vein thrombosis (DVT), genitourinary condition, and
wound complication were risk factors among causes.

Conclusion:
Cesarean delivery is one of the most important risk factors for postpartum readmission,
especially both childbirth-related/non-related complications causes. Therefore, it is necessary
to revise the schedule of postpartum visits based on the type of delivery.
Psychometric Properties of Dyadic Sexual Communication Scale- Persian Version
Authors: Bahrami Nasim , Ghorbani Sara , Griffiths Mark D. , Alimoradi Zainab 
Published: January 2024

Background and Aim:
Couples’ sexual communication is one of the contributing factors
to the quality of couples’ sexual relationships. The aim of the present study was to psychometrically
evaluate the Persian version of the Dyadic Sexual Communication Scale (DSCS) among
married women of reproductive age.

Methods:
In this psychometric study, translation was carried out using the back-translation
method. The validity of the final version of the DSCS was performed using confirmatory factor
analysis and Rasch analysis. Concurrent validity was examined using the Female Sexual Function
Index (FSFI), Female Sexual Distress Scale (FSDS) and Marital Intimacy Scale (MIS). Reliability
was assessed by calculating Cronbach’s alpha coefficient. Data analysis was performed using
SPSS and Mplus software.

Results:
The participants comprised 400 married women with a mean age of 35.66 years living in
Qazvin, Iran. Construct validity was confirmed based on confirmatory factor analysis (χ2[df]:
113.49 (65), Tucker-Lewis index: 0.980, Composite Reliability: 0.87, SRMSR: 0.065, RMSEA:
0.043, CFI: 0.983. Concurrent validity was analyzed using Pearson correlation coefficients, and
the DSCS was positively correlated with scores on the MIS (r=.64) and FSFI (r=.65) and negatively
correlated with scores on the FSDS (r=-.61). The internal reliability of the Persian DSCS
was very good (Cronbach’s alpha=.88).

Conclusion:
Based on psychometric testing, the Persian DSCS has good validity and reliability.
Therefore, the tool can be used to assess women’s sexual communication in the context of sexual
relationships. Future research should include males and compare and contrast results with females.
Construction of a Miniaturized Electrochemical Sensor for Voltammetric
Detection of 17β-Estradiol Using a g-C3N4-Decorated Gold Nanoparticles
Electrode
Authors: Ma Yue , Liu Xuqiao , Yan Kai , Zhang Jingdong 
Published: January 2024

Background:
17β-estradiol (E2) is a steroid hormone that has the potential to disrupt the
endocrine system, leading to adverse effects on both humans and ecosystems, even when present in
low concentrations. The quantitative determination of E2 is of great practical significance.

Hypothesis:
Electrochemical methods offer several advantages, including low cost, ease of operation,
and potential for miniaturization, which makes them suitable for on-field detection applications.

Methods:
This research developed a miniaturized electrochemical sensor utilizing graphitic carbon
nitride (g-C3N4) assembled on an AuNPs/ITO film electrode for sensitive voltammetric detection of
a steroid hormone, E2.

Results:
Compared with AuNPs/ITO electrodes, the g-C3N4/AuNPs/ITO exhibits higher sensitivity
for voltammetric detection of E2. Under optimal conditions, the differential pulse voltammetric response
on the g-C3N4/AuNPs/ITO electrode was proportional to E2 concentration in the 25 ~ 600
μmol/L range, with a detection limit of 6.5 μmol/L.

Conclusion:
The proposed g-C3N4/AuNPs/ITO electrode exhibited a wide linear range, good selectivity,
and practical applicability for determining E2 in environmental water samples with acceptable
recovery.
Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta-
Analysis and Systematic Review
Authors: Hashemi Rafsanjani Mahmood Reza , Rahimi Rasoul , Heidari-Soureshjani Saeid , Darvishi Mohammad , Adeli Omid-Ali , Abbaszadeh Saber 
Published: January 2024

Background:
Hepatocellular Carcinoma (HCC) is a public health problem around the
world. Several studies have investigated the association between statin use and the risk of HCC,
however, more studies are needed in this field.

Objectives:
This systematic review and meta-analysis aimed to investigate the relationship between
statin use and HCC risk.

Methods:
Systematic searches of Web of Science, Scopus, PubMed, Cochrane, Science Direct,
and Embase were conducted for studies published between 1980 and September 2023. Metaanalyses
were performed using Stata 15 with a significance level of 0.05.

Results:
The search retrieved 8,125 articles, of which 40 were included in the meta-analysis
after applying eligibility criteria. The total sample was 5,732,948 participants, including 68,698
HCC cases. Statin use was associated with a 44% lower risk of HCC compared to non-use (RR
0.56, 95% CI 0.50–0.63, p < 0.001). The RR was 0.54 (0.42-0.69) in American countries, 0.52
(0.44-0.62) in Asian countries, and 0.63 (0.48-0.84) in European countries. The RR was 0.50
(0.42-0.60) in studies with a mean age <50 years and 0.61 (0.53-0.70) in studies with a mean
age ≥50 years. No evidence of publication bias was found (Begg’s test p = 0.718).

Conclusion:
This meta-analysis found statin use is associated with a significantly lower HCC
risk. Statins may be a promising preventive intervention against HCC
Prediction of Drug Pathway-based Disease Classes using Multiple Properties of Drugs
Authors: Chen Lei , Li Linyang 
Published: January 2024

Background:
Drug repositioning now is an important research area in drug discovery as
it can accelerate the procedures of discovering novel effects of existing drugs. However, it is challenging
to screen out possible effects for given drugs. Designing computational methods are a quick
and cheap way to complete this task. Most existing computational methods infer the relationships
between drugs and diseases. The pathway-based disease classification reported in KEGG provides
us a new way to investigate drug repositioning as such classification can be applied to drugs. A predicted
class of a given drug suggests latent diseases it can treat.

Objective:
The purpose of this study is to set up efficient multi-label classifiers to predict the classes
of drugs.

Methods:
We adopt three types of drug information to generate drug features, including drug pathway
information, label information and drug network. For the first two types, drugs are first encoded
into binary vectors, which are further processed by singular value decomposition. For the third type,
the network embedding algorithm, Mashup, is employed to yield drug features. Above features are
combined and fed into RAndom k-labELsets (RAKEL) to construct multi-label classifiers, where
support vector machine is selected as the base classification algorithm.

Results:
The ten-fold cross-validation results show that the classifiers provide high performance
with accuracy higher than 0.95 and absolute true higher than 0.92. The case study indicates the novel
effects of three drugs, i.e., they may treat new diseases.

Conclusion:
The proposed classifiers have high performance and are superiority to the classifiers
with other classic algorithms and drug information. Furthermore, they have the ability to discover
new effects of drugs.
Novel N-(3-ethynyl Phenyl)-6,7-bis(2-methoxyethoxy)Quinazoline-4-amine Derivatives:
Synthesis, Characterization, Anti-cancer Activity, In-silico and DFT Studies
Authors: Dash Amitananda , Vaddamanu Guruswamy , Karreddula Raja , Manubolu Surya Surendra Babu , G. Pavana Kumari , Mulakayala Naveen 
Published: January 2024

Background:
Cancer is one of the most common reasons for mortality in the world. A continuous effort to
develop effective anti-cancer drugs with minimum side effects has become necessary. The use of small-molecule drugs
has revolutionized cancer research by inhibiting cancer cell survival and proliferation. Quinazolines are a class of bioactive
heterocyclic compounds with active pharmacophores in several anti-cancer drugs. Such small molecule inhibitors
obstruct the significant signals responsible for cancer cell development, thus blocking these cell signals to prevent cancer
development and spread.

Objective:
In the current study, novel quinazoline derivatives structurally similar to erlotinib were synthesized
and explored as novel anti-cancer agents.

Methods:
All the synthesized molecules were confirmed by spectroscopic techniques like 1H NMR, 13C NMR,
and ESI-MS. Various techniques were applied to study the protein-drug interaction, DFT analysis, Hirshfeld
surface, and target prediction. The molecules were screened in vitro for their anti-cancer properties against 60
human tumor cell lines. The growth inhibitory properties of a few compounds were studied against the MCF7
breast cancer cell line.

Results:
The activity of compounds 9f, 9o, and 9s were found to be active. However, compound 9f is more active
when compared with other compounds.

Conclusion:
Some synthesized compounds were active against different cancer cell lines. The in-vitro study
results were found to be in agreement with the predictions from in-silico data. The selected molecules were further
subjected to get the possible mechanism of action against different cancer cells.
Comparing The Mediterranean and The Japanese Dietary Pattern in Relation to Longevity - A Narrative Review
Authors: Damigou Evangelia , Kosti Rena Isaac , Downs Shauna Mae , Naumovski Nenad , Panagiotakos Demosthenes 
Published: January 2024

:
The Mediterranean dietary pattern (MDP) and Japanese dietary pattern (JDP) have
received increasing attention from the scientific community and media, predominantly due to
their association with increased longevity and health. Although similarities between the two
dietary patterns are evident, a detailed comparison between them is still relatively unexplored.
This narrative review aimed to explore the similarities and differences between the MDP and
JDP in terms of longevity while also reflecting on the adoption of these diets by other populations
outside their regions of origin. Both dietary patterns are plant-based, minimally processed,
and sustainable for their respective regions and have been shown to significantly prolong life
expectancy in different populations. Nevertheless, these dietary patterns also differ in terms of
macronutrient ratios, food preparation and consumption and individual cultural characteristics
of each population. Additionally, both dietary patterns are part of broader lifestyle patterns,
which include other behaviors, such as abstaining from smoking, engaging in regular physical
activity, having low stress levels and a sense of community, spirituality/religiousness and purpose.
The promotion of these two dietary patterns should be implemented in other regions after
considering cultural and socio-economical characteristics.
Development and Validation of a Nomogram for Predicting Breast
Malignancy in Male Patients Based on Clinical and Ultrasound Features
Authors: Dong Wei-Hong , Wu Gang , Zhao Nan , Zhang Juan 
Published: January 2024

Objective::
This study aimed to construct a nomogram based on clinical and ultrasound
(US) features to predict breast malignancy in males.

Methods::
The medical records between August, 2021 and February, 2023 were retrospectively
collected from the database. Patients included in this study were randomly divided into training
and validation sets in a 7:3 ratio. The models for predicting the risk of malignancy in male patients
with breast lesions were virtualized by the nomograms

Results::
Among the 71 enrolled patients, 50 were grouped into the training set, while 21 were
grouped into the validation set. After the multivariate analysis was done, pain, BI-RADS category,
and elastography score were identified as the predictors for malignancy risk and were selected
to generate the nomogram. The C-index was 0.931 for the model. Concordance between
predictions and observations was detected by calibration curves and was found to be good in
this study. The model achieved a net benefit across all threshold probabilities, which was shown
by the decision curve analysis (DCA) curve.

Conclusion::
We successfully constructed a nomogram to evaluate the risk of breast malignancy
in males using clinical and US features, including pain, BI-RADS category, and elastography
score, which yielded good predictive performance.
Mechanical and Morphological Analysis of Aramid Fiber (PPTA), Glass
Wool (GW), Aluminum (Al), and Silicon Carbide (SiC) Particles
Embedded High-density Polyethylene (HDPE) Hybrid Composites
Authors: Ahmed Rajib , Hasan Mahbub , Sheikh Md. Rezaul Karim , Faruqui A. Nayeem 
Published: January 2024

Introduction:
Composite research is adopting innovative materials in the current period
due to their better qualities, such as being lightweight, having excellent mechanical properties, being
relatively inexpensive, having a low coefficient of thermal expansion, etc.

Method:
Composite materials play a crucial part in this challenge, with the fast market growth for
lightweight and high-performance materials. In the present research, different weight percentages of
aramid fiber, glass wool, aluminum, and silicon carbide-reinforced high-density polyethylene hybrid
composite are introduced. The degree of adhesion between the matrix and reinforcement was determined through microstructural investigation utilizing an optical and scanning electronic microscope.

Result:
Mechanical properties (tensile behaviors, flexural behavior, impact strength and hardness
property) of the fabricated composites are investigated. Comparative study of mechanical properties
for different combinations of fabricated composites reveals an increase in elongation at break, flexural
strength, flexural modulus and hardness, while tensile strength and impact strength have decreased
sequentially from 5 to 40 wt.%.

Conclusion:
The mechanical properties of HDPE-PPTA-GW-Al-SiC hybrid composites obtained at
40 wt.% PPTA [Poly (p-phenylene terephthalamide)], GW (glass wool), Al, and SiC powder loading
are superior as compared to other hybrid composites.