bluuebunny/crossref_metadata_2025_split huggingface dataset:
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
Authors: Lorenz Marco , Fuest Kristina , Ulm Bernhard , Grunow Julius J. , Warner Linus , Bald Annika , Arsene Vanessa , Verfuß Michael , Daum Nils , Blobner Manfred , Schaller Stefan J. 
Published: November 2023

Abstract
Background
This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis was that interventions lasting over 40 min, as per the German guideline, positively affect the functional status at ICU discharge.

Methods
Prospective single-centre cohort study conducted in two ICUs in Germany. In 684 critically ill patients surviving an ICU stay > 24 h, out-of-bed mobilisation of more than 40 min was evaluated.

Results
Daily mobilisation ≥ 40 min was identified as an independent predictor of an improved functional status upon ICU discharge. This effect on the primary outcome measure, change of Mobility-Barthel until ICU discharge, was observed in three different models for baseline patient characteristics (average treatment effect (ATE), all three models p < 0.001). When mobilisation parameters like level of mobilisation, were included in the analysis, the average treatment effect disappeared [ATE 1.0 (95% CI − 0.4 to 2.4), p = 0.16].

Conclusions
A mobilisation duration of more than 40 min positively impacts functional outcomes at ICU discharge. However, the maximum level achieved during ICU stay was the most crucial factor regarding adequate dosage, as higher duration did not show an additional benefit in patients with already high mobilisation levels.
Trial registration: Prospective Registry of Mobilization-, Routine- and Outcome Data of Intensive Care Patients (MOBDB), NCT03666286. Registered 11 September 2018—retrospectively registered,
https://classic.clinicaltrials.gov/ct2/show/NCT03666286.
Efficacy of small back optic zone design on myopia control for corneal refractive therapy (CRT): a one-year prospective cohort study
Authors: Li Xuewei , Zuo Lili , Zhao Heng , Hu Jie , Tang Tao , Wang Kai , Li Yan , Zhao Mingwei 
Published: November 2023

Abstract
Background
To investigate the control effect on the axial length elongation using corneal refractive therapy (CRT) with different optical zone diameters (BOZDs). We also sought to compare the difference in higher-order aberrations (HOAs), treatment zone (TZ) size and Zernike defocus coefficient with different BOZDs and seek the optimal parameter for predicting axial elongation.

Methods
This prospective cohort study included 7- to 14-year-olds fitted with orthokeratology (ortho-K) lenses of 5-mm (5-mm group) or 6-mm BOZD (6-mm group). Axial length (AL), corneal topography, HOAs and Zernike defocus coefficient were obtained at baseline, and 1, 3, 6, 9 and 12 months follow-up visits. Multivariate regression analyses were used to explore the association between AL change and ocular biometric parameters. Receiver operating characteristic (ROC) curve analysis was used to determine the best diagnostic value for AL change in ocular biometric parameters.

Results
In total, 301 participants completed the one-year follow-up. The mean AL change in the 5-mm group (0.13 ± 0.18 mm) was less than that in the 6-mm group (0.27 ± 0.15 mm) at the 12 months visit. The TZ size and decentration were smaller, while the Zernike defocus coefficient and HOAs were higher in the 5-mm group (all P < 0.05). Older age and smaller TZ size were protective factors against AL elongation in multiple regression. In predicting AL elongation, TZ diameter yielded an area under the ROC curve of 0.684 with a cut-off value of 3.82 mm.

Conclusion
The 5-mm group showed 0.14 mm (51.8%) less axial elongation than the 6-mm group. The 5-mm BOZD produced a smaller TZ size, higher Zernike defocus coefficient and higher HOA after reshaping of the cornea. TZ size was the best predictor of AL elongation. TZ diameter less than 3.82 mm may lead to AL elongation less than 0.2 mm in one year.
Price Transparency for Cervical Spinal Fusion Among High-Performing Spine Centers in the United States
Authors: Yoon James S. , Ng Patrick R. , Hoffman Samantha E. , Gupta Saksham , Mooney Michael A. 
Published: November 2023

BACKGROUND AND OBJECTIVES:
As of January 1, 2021, all US hospitals are required by the Hospital Price Transparency Final Rule (HPTFR) to publish standard charges for all items and services, yet the state of price transparency for cervical spinal fusion is unknown. Here, we assess the nationwide price transparency landscape for cervical spinal fusion among high-performing spine centers in the United States.

METHODS:
In this cross-sectional economic evaluation, we queried publicly available price transparency websites of 332 “high-performing” spine centers, as defined by the US News and World Report. We extracted variables including gross charges for cervical spinal fusion, payor options, price reporting methodology, and prices relevant to consumers including listed cash prices and minimum and maximum negotiated charges.

RESULTS:
While nearly all 332 high-performing spine surgery centers (99.4%) had an online cost estimation tool, the HPTFR compliance rate was only 8.4%. Gross charges for cervical spinal fusion were accessible for 68.1% of hospitals, discounted cash prices for 46.4% of hospitals, and minimum and maximum charges for 10.8% of hospitals. There were large IQRs for gross charges ($48 491.98-$99 293.37), discounted cash prices ($26 952.25-$66 806.63), minimum charges ($10 766.11-$21 248.36), and maximum charges ($39 280.49-$89 035.35). There was geographic variability in the gross charges of cervical spinal fusion among high-performing spine centers within and between states. There was a significant association between “excellent” discharge to home status and lower mean gross charges.

CONCLUSION:
Although online cost reporting has drastically increased since implementation of the HPTFR, data reported for cervical spinal fusion remain inadequate and difficult to interpret by both providers and patients.
Case Report: Severe ischemic priapism as the clinical presentation in patient with chronic myeloid leukemia (CML) treated by proximal shunt
Authors: Dahril Dahril , Ramadhan Sangaji 
Published: November 2023

Background: Priapism refers to an erection of the penis that persists for four hours or more and is not associated with sexual arousal or stimulation. This condition is thought to be caused by abnormal production of blood cells in the bone marrow, which leads to the release of certain chemicals into the bloodstream. The current article presents a severe ischemic priapism case, and assesses and contrasts the documented instances of patients with chronic myelogenous leukemia (CML) who experienced priapism as their primary clinical symptom over the last two decades. Case presentation: The 21-year-old male patient presented with persistent and painful erections for three days. Further tests revealed he had CML and ischemic priapism. He was treated with distal shunting and proximal shunting with cytoreductive therapy to resolve the symptoms. Conclusions: Priapism is a medical emergency that can cause permanent damage to the erectile tissue if not treated promptly. Prolonged and painful erections can cause ischemia, leading to tissue damage and decreased function. If priapism is caused by an underlying medical condition; delaying treatment can allow the underlying condition to progress and become more difficult to treat.
Global existence for time-dependent damped wave equations with nonlinear memory
Authors: Kirane Mokhtar , Fino Ahmad Z. , Alsaedi Ahmed , Ahmad Bashir 
Published: November 2023

Abstract
In this article, we consider the Cauchy problem for a semi-linear wave equation with time-dependent damping and memory nonlinearity. Conditions for global existence are presented in the energy space

H

1

(

R

n

)

×

L

2

(

R

n

)

{H}^{1}\left({{\mathbb{R}}}^{n})\times {L}^{2}\left({{\mathbb{R}}}^{n})

,

n
≥
1

n\ge 1

.
MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
Authors: Xie Jia-Bei , Zhang Hao , Li Xiao-Fang , Han Shuang-Yin , Li Xiu-Ling 
Published: November 2023

Abstract
This study aimed to investigate the interaction between miR-1278 and Caldesmon (CALD1) in gastric cancer (GC) and the regulatory mechanism. In both GC cells and tissues, the levels of CALD1, miR-1278, migration-related markers (E-cadherin, N-cadherin, and Snail), and MAPK signaling pathway-related proteins were clarified using quantitative real-time PCR and western blotting analyses. The effects of miR-1278 and CALD1 on GC cell viability and migration were analyzed using CCK-8 and Transwell assays, respectively. The targeting effect of miR-1278 on CALD1 was investigated using bioinformatics prediction and a dual luciferase reporter assay. The effect of miR-1278 on tumor growth was estimated in vivo using a tumor xenograft assay. In GC, miR-1278 expression decreased, whereas CALD1 was highly expressed. Transfecting an miR-1278 mimic into cells inhibited the viability as well as migration of GC cells, and suppressed Ras, phosphorylated (p)-P38, and p-ERK1/2 protein levels. Moreover, miR-1278 targeted and negatively regulated CALD1 expression. CALD1 overexpression promoted GC cell survival and migration and activated the MAPK pathway. Treatment with an miR-1278 mimic partially rescued the changes caused by CALD1 overexpression. Overall, our study revealed that miR-1278 suppresses the malignant behavior of GC cells by targeting CALD1 and regulating the MAPK pathway.
Social Benefits of Cooperatives - An Economic Perspective
Authors: Wrede Matthias 
Published: November 2023

Abstract
Why and how are cooperatives beneficial to society? The answer is simple: first and foremost, because they are useful for the members. Cooperatives enable them to cooperate and operate economically. Members benefit because they can pool resources, save on transaction costs and hold their own against companies with market power. The purpose and democratic governance protect against exploitation, even in the face of the high opportunity cost of terminating membership. What should the state do? Cooperatives should be supported by structuring their legal form in a way that is appropriate to their purpose and practical. Financial support for cooperatives is recommended if external effects are internalized or more targeted alternative redistribution instruments do not exist.
Nachhaltigkeit von Genossenschaftsbanken
Authors: Thimm Philipp , Blome-Drees Johannes 
Published: November 2023

Zusammenfassung
In der vorliegenden Abhandlung werden ausgewählte empirische Ergebnisse einer von der DZ Bank-Stiftung geförderten Studie zum Thema „Nachhaltigkeit von Genossenschaftsbanken" vorgestellt. Die konzeptionellen Überlegungen und empirischen Befunde zeigen, dass die morphologischen Besonderheiten der Genossenschaftsbanken eine nachhaltige Unternehmenspolitik begünstigen können. Die Ausführungen machen weiter deutlich, dass es diese Vorteile strategisch zu nutzen gilt. Dies ist insbesondere mit Blick auf künftige regulatorische Anforderungen von besonderer Relevanz.
Cell‐based allometry: an approach for evaluation of complexity in morphogenesis
Authors: Tarihi Ali , Tarihi Mojtaba , Tiraihi Taki 
Published: November 2023

BackgroundMorphogenesis is a complex process in a developing animal at the organ, cellular and molecular levels. In this investigation, allometry at the cellular level was evaluated.MethodsGeometric information, including the time‐lapse Cartesian coordinates of each cell’s center, was used for calculating the allometric coefficients. A zero‐centroaxial skew‐symmetrical matrix ( CSSM), was generated and used for constructing another square matrix (basic square matrix: BSM), then the determinant of BSM was calculated ( d). The logarithms of absolute d (Lad) of cell group at different stages of development were plotted for all of the cells in a range of development stages; the slope of the regression line was estimated then used as the allometric coefficient. Moreover, the lineage growth rate (LGR) was also calculated by plotting the Lad against the logarithm of the time. The complexity index at each stage was calculated. The method was tested on a developing Caenorhabditis elegans embryo.ResultsWe explored two out of the four first generated blastomeres in C. elegans embryo. The ABp and EMS lineages show that the allometric coefficient of ABp was higher than that of EMS, which was consistent with the complexity index as well as LGR.ConclusionThe conclusion of this study is that the complexity of the differentiating cells in a developing embryo can be evaluated by allometric scaling based on the data derived from the Cartesian coordinates of the cells at different stages of development.
Assessment and Management of Atopic Dermatitis in Primary Care Settings
Authors: Najlaa Mohammad Alsudairy  , Shorooq Ahmed Hamzi  , Eman Ahmed M Alrashed  , Baraah Ahmad Aldeera  , Ali Ibrahim Al Hussain  , Aldhafeer Eman Saad A , Almenyan Zahra Ali , Abdulaziz Khalid Albulaihed  , Nawaf Abdullah Alshahrani  , Mohammed Ibrahim Alsaeed  , Al Hashim Khadijah Yaseen A , Renad Naif Alotaibi  , Abdulelah Fahad Almansour  
Published: November 2023

An increasingly common chronic inflammatory skin condition is atopic dermatitis (AD). It exhibits severe itching as well as recurring eczematous lesions. New difficulties for treatment selection and approach occur with the expansion of available therapy alternatives for healthcare professionals and patients. The article highlights recent developments in scientific research on atopic dermatitis diagnosis and assessment that have led to the identification of novel therapeutic targets and the development of targeted therapies, both of which have the potential to completely change the way AD is treated, particularly in a primary care setting.
Association of Socio-Psychological Factors on Decision Making Process of Kvk Officials in Odisha
Authors: Smaranika Mohanty  , Mahamaya Prasad Nayak  , Santosh Kumar Rout  , Rajeeb Ku. Behera  , Anshuman Jena  , Soumya Sakti Dash  , Sweta Sahoo  , Rakesh.Ku.Pattnaik  
Published: November 2023

The role of research and extension system in delivery of appropriate technology to the farmers has been looked at as the most important input for furthering agricultural production. Therefore, considering the requirement of developing the capacity of the farmers and reducing the time lag between technology generation and technology application at farmer’s field; the idea of establishing KVK under the leadership of Dr. Mohan Singh Mehta appointed by ICAR in 1973 took place. The present study is an exploratory survey design undertaking 125 respondents comprising of Sr. Scientist & Head, Scientists, Program Assistants and Farm managers selected randomly from 33 KVKs across the state. The findings of the study revealed that majority of the respondents (56.80%) were middle aged, 64 per cent of them were male officials and (68.00%) of the sample reported to experience moderate level of Job Satisfaction, Job Autonomy and Organizational Stress. Further, Organizational Climate (76.00%) and the Level of Job Management (72.00%) of the KVK was also reported to be moderate. The average gap in participation was maximum in identifying the problem/needs (38.40%) and policy decisions (39.40%) among the all the different stages of decision-making and types of decision-making respectively. Further, it was observed that Professional Experience, Organizational Stress, Job Autonomy and Level of Job Management was strongly associated with extent of Participation in different types of Decision-making. The findings also revealed that Level of Job Management was found to be associated with participation in different stages of decision-making.
SYSTEMATIC LITERATURE REVIEW: PERAN PEMBELAJARAN KIMIA TERHADAP KEBERLANJUTAN DALAM KONTEKS EDUCATION FOR SUSTAINABLE DEVELOPMENT (ESD)
Authors: Febrizal Febrizal , Hernani Hernani , Mudzakir Ahmad 
Published: November 2023

Penelitian ini dilatarbelakangi perlunya studi literatur mengenai bagaimana keberlanjutan penting untuk didukung dalam sebuah pembelajaran di tingkat formal. Tujuan utama dalam penelitian ini adalah mengkaji upaya-upaya yang dilakukan untuk mewujudkan keberlanjutan melalui pembelajaran kimia. Peran ini difokuskan dalam dua hal yaitu Melalui pembelajaran kimia ramah lingkungan yang kemudian dapat diterapkan dalam dunia industri maupun kehidupan sehari-hari dan peningkatan kesadaran lingkungan dan kesadaran keberlanjutan. Metode yang digunakan yaitu systematic literature review, yang terdiri atas tiga tahap yaitu planning, conducting, dan reporting. Tahap planning berupa penetapan protokol meliputi penentuan topik dan penetapan kriteria pencarian artikel, Tahap conducting yaitu pelaksanaan meliputi pencarian artikel, pemilihan artikel, dan sintesis data. Tahap reporting yaitu tahapan akhir yang meliputi penulisan hasil systematic literature review sesuai dengan format yang telah ditentukan. Hasil yang diperoleh dari 10 artikel yang dikaji menunjukkan bahwa beberapa peran kimia dalam menjaga keberlanjutan melalui pembelajaran kimia berorientasi praktik yang ramah lingkungan dan dari 15 artikel yang dikaji menunjukkan hubungan pembelajaran dalam konteks ESD dengan kesadaran lingkungan (Evironmental awareness) kesadaran keberlanjutan (Sustainability awareness).
Fully Endoscopic Microvascular Decompression for Hemifacial Spasm: A Clinical Study and Analysis
Authors: Zheng Xialin , Shao Dongqi , Cai Longjie , Xie Shan , Li Yu , Jiang Zhiquan 
Published: November 2023

Abstract
Objective: Fully endoscopic microvascular decompression of the facial nerve is a pivotal surgical approach for treating hemifacial spasm. However, it presents distinct surgical challenges and necessitates a learning curve. Hence, this study aimed to consolidate surgical insights and assess clinical outcomes based on a retrospective analysis of prior cases.
Methods: Clinical data from 16 patients with facial nerve spasms treated at the Department of Neurosurgery in the First Affiliated Hospital of Bengbu Medical College, between August 2020 and July 2023, were retrospectively examined. Preoperatively, all patients underwent magnetic resonance angiography to confirm the presence or absence of responsible blood vessels, ascertain the relationship between responsible blood vessels, facial nerves, and brainstem, and detect any cerebellopontine angle lesions. The surgical technique encompassed entirely endoscopic microvascular decompression of the facial nerve, employing a mini sigmoid sinus posterior approach. The operative nuances and clinical efficacy were summarized and analyzed. The former encompassed intraoperative positioning, incision design, bone window parameters, mirror-handling methodology, crucial points of collaboration between the surgeon and assistant, and intraoperative management of responsible blood vessels. The latter included typical postoperative complications and the extent of relief from facial paralysis.
Results: All 16 patients successfully underwent the procedure, with the responsible blood vessels identified and adequately padded during surgery. These comprised 12 cases of anterior inferior cerebellar artery (75%), 3 cases of vertebral artery (18.75%), and 1 case of posterior inferior cerebellar artery (6.25%). Intraoperative electrophysiological monitoring of lateral spread response of the facial nerve entirely vanished in 15 cases and remained unchanged in 1 case. Postoperative facial spasms were promptly alleviated in 15 cases (93.75%) and delayed in 1 case (6.25%). Two cases of postoperative complications were recorded; one instance of intracranial infection, which resolved following lumbar cistern external drainage and anti-infective treatment, and one case of tinnitus, mitigated through oral administration of mecobalamin and nimodipine. All patients were subject to follow-up, with no instances of recurrence or mortality.
Conclusion: Complete endoscopic microvascular decompression of the facial nerve proves to be both safe and effective. Proficiency in endoscopy and surgical skills are pivotal, thereby discouraging novices in endoscopy from performing this procedure.
Directions and Prospects for the Development of Public Governance
Authors: Doronin A. N. 
Published: November 2023

This article discusses issues and problems related to the modern development of public administration in the face of uncertainty and economic crisis, as well as a tense socio-political situation. The paper studies the main theoretical approaches of the authors to the concept of “public administration”, based on the evolution of the main concepts on thistopic. In addition, the article analyzes the directions of development of public administration in Russia. Attempts are being made to study further prospects for the development of public administration. The relevance of the topic of this article is explained by the fact that today the issues and problems related to the development of public administration in Russia have a strategic focus, since in the current conditions the management mechanisms of state and municipal authorities are ineffective and require serious changes. This also applies to the regulatory framework that regulates the activities of government bodies. It needs some changes and some additions. In addition, it is worth saying that modern society, being on the path of transformation, digitalization and active use of the Internet, have the opportunity to ask questions about government directly. Goal. Study of the main directions of public administration development in Russia and its further prospects. Tasks. In the course of the research, such tasks were solved as: studying the authors’ approaches to the concept of “public administration”, identifying the main features and directions of public administration development, identifying problems and prospects for the development of public administration, taking into account complex crisis and stressful conditions.Methodology. It includes theoretical methods, the method of analysis, the method of forecasting with regard to development prospects. Conclusions. In the conditions of the existing instability, crisis and a large number of sanctions, new approaches and methods to the development of public administration are required. This is due to the fact that the previously existing mechanisms of state and municipal authorities are not fully effective. Also, changes are required by the regulatory legislative frame-work, which regulates the principles of public power management at both the federal and municipal levels.
O trabalho temporário na cafeicultura do Planalto da Conquista nas décadas de 1970 e 1980
Authors: Santana Aurelane Alves 
Published: November 2023

Este artigo consiste na análise do trabalho temporário na cafeicultura do Planalto da Conquista nas décadas de 1970 e 1980. Nele, visa-se explanar teoricamente como se constituiu o trabalho temporário com o avançar do capitalismo no campo e apresentar algumas das características dessa modalidade laboral pelas vozes de trabalhadores que vivenciariam a intermitência do trabalho na região. Além de revisão bibliográfica de autores como Singer (1977), Bastos e Gonzales (1977), D’incao (1984), dentre outros, utilizou-se também a pesquisa de campo, a qual foi fundamental para o colhimento de depoimentos de pessoas que experienciaram essas mudanças e que foram submetidos ao trabalho temporário nas fazendas de café do Planalto da Conquista.

Palavras-chave: Trabalho temporário, Cafeicultura, Planalto da Conquista, Trabalhadores.