bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous coronary intervention for chronic total occlusion of the left circumflex branch in mirror dextrocardia: a case report
Authors: Hailin Du , Hongtu Qiao , Wenyong Zhang 
Published: November 2023

Abstract
Background
Mirror dextrocardia (MDC) is a condition in which the heart is located in a mirror-image position on the right side of the chest compared to the normal position in individuals with physiological variations. Patients with MDC and chronic total occlusion (CTO) of the left circumflex branch (LCX) are extremely rare in clinical practice. The treatment of MDC-CTO-LCX differs significantly from patients without mirror dextrocardia and the same condition in terms of instrument selection and procedural techniques. In this article, we report a successful case of interventional treatment in a patient with MDC-CTO-LCX. We summarize the anatomical and electrocardiographic variations in patients with MDC-CTO-LCX, and discuss the selection of interventional instruments and techniques that can be useful for interventionists as well as the diagnostic and therapeutic considerations that can be helpful for clinical physicians.

Case presentation
A male Han Chinese patient, 51, was admitted, presenting recurrent chest pain for a year and recent onset of exertional fatigue over the past week.He reported episodes of chest pain following physical activities over the past year, lasting between 5 and 20 min.Despite these symptoms, the patient did not seek immediate medical attention, and the occurrence of his chest pain has progressively lessened within the year.A week prior, the patient developed exertional dyspnea after brief walks, though without any episodes of nocturnal paroxysmal dyspnea.Upon arrival at our hospital for evaluation, he was initially diagnosed with chronic coronary syndrome, previous inferior myocardial infarction, atrial arrhythmia, and classified under the New York Heart Association functional class III.Following his admission, a chest X-ray and coronary angiography were conducted.The results indicated mirror dextrocardia and total occlusion of the left circumflex branch. Percutaneous coronary intervention (PCI) was performed on the left circumflex branch. Subsequent angiography demonstrated optimal stent positioning without evidence of hematoma or dissection.Following the procedure, the patient's symptoms of chest pain and exertional dyspnea were resolved, which led to his subsequent discharge.A follow-up electrocardiogram, 10 months post-procedure, displayed a slow and regular atrial rhythm.

Conclusions
The incidence of dextrocardia is very low, and it may appear normal on an electrocardiogram; however, careful diagnosis is required when there is an abnormal direction of the P wave in limb leads. During the operation for chronic occlusive lesions of the right-sided coronary artery, the anomalous anatomical structure necessitates specific requirements for instrument selection and operative techniques. After revascularization of chronic occlusive vessels in dextrocardia, routine electrocardiographic examination may show false normalization, requiring caution in interpretation.
NHS reference costs: a history and cautionary note
Authors: Amies-Cull Ben , Luengo-Fernandez Ramon , Scarborough Peter , Wolstenholme Jane 
Published: November 2023

AbstractHistorically, the NHS did not routinely collect cost data, unlike many countries with private insurance markets. In 1998, for the first time the government mandated NHS trusts to submit estimates of their costs of service, known as reference costs. These have informed a wide range of health economic evaluations and important functions in the health service, such as setting prices.Reference costs are collected by progressively disaggregating budgets top-down into disease and treatment groups. Despite ongoing improvements to methods and guidance, these submissions continued to suffer a lack of accuracy and comparability, fundamentally undermining their credibility for critical functions.To overcome these issues, there was a long-held ambition to collect “patient-level” cost data. Patient-level costs are estimated with a combination of disaggregating budgets but also capturing the patient-level “causality of costs” bottom-up in the allocation of resources to patient episodes. These not only aim to capture more of the drivers of costs, but also improve consistency of reporting between providers.The change in methods may confer improvements to data quality, though judgement is still required and achieving consistency between trusts will take further work. Estimated costs may also change in important ways that may take many years to fully understand. We end on a cautionary note that patient-level cost methods may unlock potential, they alone contribute little to our understanding of the complexities involved with service quality or need, while that potential will require substantial investment to realise. Many healthcare resources cannot be attributed to individual patients so the very notion of “patient-level” costs may be misplaced. High hopes have been put in these new data, though much more work is now necessary to understand their quality, what they show and how their use will impact the system.
Reproduction number projection for the COVID-19 pandemic
Authors: Benjamin Ryan 
Published: November 2023

AbstractThe recently derived Hybrid-Incidence Susceptible-Transmissible-Removed (HI-STR) prototype is a deterministic compartment model for epidemics and an alternative to the Susceptible-Infected-Removed (SIR) model. The HI-STR predicts that pathogen transmission depends on host population characteristics including population size, population density and social behaviour common within that population.The HI-STR prototype is applied to the ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) to show that the original estimates of the Coronavirus Disease 2019 (COVID-19) basic reproduction number $\mathcal{R}_{0}$

R
0

for the United Kingdom (UK) could have been projected onto the individual states of the United States of America (USA) prior to being detected in the USA.The Imperial College London (ICL) group’s estimate of $\mathcal{R}_{0}$

R
0

for the UK is projected onto each USA state. The difference between these projections and the ICL’s estimates for USA states is either not statistically significant on the paired Student t-test or not epidemiologically significant.The SARS-CoV2 Delta variant’s $\mathcal{R}_{0}$

R
0

is also projected from the UK to the USA to prove that projection can be applied to a Variant of Concern (VOC). Projection provides both a localised baseline for evaluating the implementation of an intervention policy and a mechanism for anticipating the impact of a VOC before local manifestation.
Evaluating three water-based systems and one organic solvent for the removal of dammar varnish from artificially aged oil paint samples
Authors: Husby Louise Maria , Andersen Cecil Krarup , Pedersen Nanna Bjerregaard , Ormsby Bronwyn 
Published: November 2023

Abstract
A framework was developed to evaluate and compare cleaning systems and cleaning system delivery methods, collectively referred to as varnish removal methods, within art conservation practice. This framework was applied to two water-based cleaning systems, optimised for the removal of dammar varnish from an artificially aged brown earth oil paint, including the surfactant-containing microemulsion, Polar Coating B (from the Nanorestore Cleaning series) delivered via the chemical gel, Higher Water Retention (HWR) (from the Nanorestore Gel Dry series), and a surfactant-free microemulsion delivered via the microfiber cloth, Evolon. In addition, two water-based systems and one organic solvent were used to remove dammar varnish from an artificially aged lead white oil paint sample, including a xanthan gum-stabilised emulsion delivered via a synthetic brush, a surfactant-free microemulsion delivered via cotton swab rolling, and 2-propanol solvent delivered via cotton swab rolling. The evaluation framework was thus applied to two different oil paints, with different sensitivities to cleaning. Through this work, the comparative advantages and disadvantages of the varnish removal methods were demonstrated. Notably, cleaning system compatibility with multiple delivery methods afforded greater versatility, including for reducing unwanted interactions between the cleaning system and oil paint. In addition, a surfactant-free microemulsion proved to be a promising, clearance-free, inexpensive, and modifiable option within current offerings for largely water-based methods for varnish removal.
The CsMYB123 and CsbHLH111 are involved in drought stress-induced anthocyanin biosynthesis in Chaenomeles speciosa
Authors: Ren Yanshen , Zhang Shuangyu , Zhao Qianyi , Wu Yang , Li Houhua 
Published: November 2023

AbstractDrought stress has been demonstrated to enhance the biosynthesis of anthocyanins in the leaves, resulting in an increased aesthetic appeal. However, the molecular mechanisms underlying drought-induced anthocyanin biosynthesis in Chaenomeles speciosa remain unclear. In this study, the metabolites of C. speciosa leaves were analyzed, and it was found that the content of cyanidin-3-O-rutinoside increased significantly under drought stress. The differentially expressed genes CsMYB123 and CsbHLH111 were isolated by transcriptomics data analysis and gene cloning, and gene overexpression and VIGS experiments verified that both play important roles in anthocyanin biosynthesis. Subsequently, Y1H and Dual-luciferase reporter assay showed that CsMYB123 binds to the promoters of anthocyanin biosynthesis-related structural genes (such as CsCHI, CsF3H, and CsANS), while CsbHLH111 was shown to bind to the promoter of CsCHI, positively regulating its activity. Furthermore, BIFC and Y2H assays unveiled potential protein–protein interactions between CsMYB123 and CsbHLH111 at the cell nucleus. Collectively, these results shed light on the critical roles played by CsMYB123 and CsbHLH111 in anthocyanin biosynthesis, thus providing a valuable insight into understanding the molecular mechanisms of how the MYB and bHLH genes regulate anthocyanin biosynthesis in the process of leaf coloration in C. speciosa.
Graphical Abstract
Burden of AML, 1990-2019: Estimates From the Global Burden of Disease Study
Authors: Jani Chinmay T. , Ahmed Alaaeldin , Singh Harpreet , Mouchati Christian , Al Omari Omar , Bhatt Padmanabh S. , Sharma Rajesh , Farooq Minaam , Liu Weitao , Shalhoub Joseph , Marshall Dominic , Salciccioli Justin D. , Warner Jeremy L. , Lam Prudence 
Published: November 2023

PURPOSE AML accounts for 80% of acute leukemia in adults. While progress has been made in treating younger patients in the past 2 decades, there has been limited improvement for older patients until recently. This study examines the global and European Union (EU) 15+ trends in AML between 1990 and 2019. METHODS We extracted age-standardized incidence rates (ASIRs), age-standardized death rates (ASMRs), and disability-adjusted life years, stratified by sex from the Global Burden of Disease Study database, and mortality-to-incidence ratio (MIR) were computed. Trends were compared using Joinpoint regression. RESULTS The findings show a global increase in AML incidence for both sexes from 1990 to 2019. In the EU15+ countries, most countries exhibited an increase in ASIR for both sexes. Joinpoint revealed that globally for male patients, ASIR steadily increased until 2010, remained stable until 2015 followed by a decline till 2019. Similar trends were observed in female patients. For ASMR, although there was an increase globally and in most EU15+ countries, there was a statistically significant decrease in mortality rates globally and in the majority of EU15+ countries in recent years. MIR improved in both sexes globally. On age stratification, AML burden was highest among older groups (55 years and older), while the lowest rates were observed in younger than 20 years. CONCLUSION The findings from our study indicate a global rise in AML incidence and mortality in both sexes and decrease in MIR from 1990 to 2019 suggesting a better survival. However, on Joinpoint analysis, there is no change in MIR in women in the past decade and past 4 years in men indicating plateau in survival trends despite recent advances.
True Continuous Segment of Ossification of Posterior Longitudinal Ligament is Protective Against Postoperative Early Kyphosis Progression After Laminoplasty
Authors: An Sungjae , Lee Jang-Bo , Lee Subum , Oh Younggyu , Park Jung-Yul , Hur Junseok W 
Published: November 2023

BACKGROUND AND OBJECTIVES:
Ossification of the posterior longitudinal ligament (OPLL) is a potentially catastrophic disease. Laminoplasty (LP) is a common surgical intervention, but postoperative kyphosis progression is a major complication, for which various risk factors have been identified and used in surgical decision-making. Our focus is on the ability of OPLL with specific morphological traits, designated as the true continuous segment (TCS), to stabilize alignment and prevent postoperative kyphosis after LP.

METHODS:
This retrospective case-control study included patients who underwent cervical LP for OPLL treatment with a minimum 1-year follow-up. Demographic, operative, and radiographic parameters were analyzed. TCS is defined as a continuous segment of OPLL that spans the disk space more than half of the adjacent vertebral body height without crack, or OPLL segment attached to both upper and lower adjacent vertebral bodies by bridging, or obvious interbody autofusion, and is identified from preoperative computed tomography. A subgroup analysis for preoperatively lordotic patients, divided into 2 groups based on cervical alignment at the final follow-up, was conducted to identify risk factors for kyphosis progression. Difference analysis, linear regression analysis for loss of lordosis (LoL), and logistic regression analysis for kyphosis progression were used.

RESULTS:
A total of 84 patients were identified. Among them, 78 patients with preoperatively lordotic alignment were divided into 2 groups: those who maintained lordotic alignment (n = 60) and those who progressed to kyphosis (n = 18). Regression analyses revealed a significant protective effect of TCS count against LoL and postoperative kyphosis, with a TCS count of 3 or more conclusively preventing kyphosis (sensitivity 1.000, specificity 0.283, area under the curve 0.629).

CONCLUSION:
For patients with OPLL, TCS was shown to protect against the LoL after LP. Therefore, TCS should be identified and considered when planning surgical treatment for OPLL.
Blockchains beyond digital currencies
Authors: Καψούλης Νικόλαος 
Published: November 2023

Οι δυνατότητες ανάπτυξης εφαρμογών σε αλυσίδες-κορμού έχουν επεκταθεί την τελευταία δεκαετία σε μεγάλο βαθμό πέρα από τα κρυπτονομίσματα. Το Διαδίκτυο επόμενης γενιάς απαιτεί οι διάφορες βιομηχανικές εφαρμογές να βασίζονται σε ισχυρές απαιτήσεις απορρήτου και ιδιωτικότητας δεδομένων. Σε αυτήν την διδακτορική διατριβή μελετάται η εφαρμοσιμότητα της ιδιωτικότητας δεδομένων σε δίκτυα αλυσίδας-κορμού μέσω της αρχιτεκτονικής σχεδίασης και ανάπτυξης ανόμοιων και ενιαίων εφαρμογών. Παρουσιάζονται σχετικές υλοποιήσεις με γνώμονα την προστασία της ιδιωτικότητας των δεδομένων σε κοινές βιομηχανικές αρχιτεκτονικές που αφορούν αναγνώριση της ταυτότητας χρηστών, διαχείριση πνευματικών δικαιωμάτων καθώς και συμφωνίες επιπέδου υπηρεσίας υπολογιστικού νέφους, ενώ αναλύονται οι τρόποι με τους οποίους εφαρμόζεται το απόρρητο δεδομένων ξεχωριστά σε κάθε περίπτωση χρήσης και ανάλογα με τις αντίστοιχες ιδιότητες της εκάστοτε αλυσίδας. Ειδικότερα, όσον αφορά τις διαδικασίες αναγνώρισης ταυτότητας χρηστών, μελετάται η ιδιωτικότητα διαδικασιών Know Your Customer σε συγκεκριμένα πλαίσια αποκεντρωμένης αρχιτεκτονικής αλυσίδας-κορμού και υλοποιείται αντίστοιχα στην παρούσα διατριβή. Όσον αφορά τη διαχείριση πνευματικών δικαιωμάτων, η διατριβή μελετά μια αποκεντρωμένη εφαρμογή έξυπνων συμβολαίων αλυσίδας-κορμού κοινοπραξίας που αφορά τη διαχείριση δικαιωμάτων στη μουσική βιομηχανία. Σχετικά με την περίπτωση χρήσης υπολογιστικού νέφους, προτείνεται μια αμερόληπτη διαδικασία αξιολόγησης συμφωνιών επιπέδου υπηρεσίας που αξιοποιεί την απομόνωση έξυπνων συμβολαίων σε επίπεδο υποδομής. Η ανάλυση της ιδιωτικότητας δεδομένων σε καθεμία από τις προαναφερθείσες βιομηχανικές αρχιτεκτονικές ορίζει συγκεκριμένα επίπεδα ιδιωτικότητας για την τεχνολογία της αλυσίδας-κορμού. Εν κατακλείδι, η διατριβή εξετάζει ξεχωριστά τα αποτελέσματα κάθε ενιαίας εφαρμογής και τις μελλοντικές τους διαστάσεις, και συνάγει μια ολιστική αρχιτεκτονική στοίβα της τεχνολογίας η οποία οραματίζεται τους διάφορους τρόπους εφαρμοσιμότητας της ιδιωτικότητας για το Διαδίκτυο επόμενης γενιάς.
Digital activism for sustainable tourism: Management of social media Instagram @travelxism through voluntrip activities
Authors: Firdausi Firna Zahwa , Muktaf Zein Mufarrih 
Published: November 2023

The advancement of information technology is rapidly transforming corporate communication activities. Social media platforms like Instagram have become a practical alternative for companies to promote a social movement, as demonstrated by the Instagram account @travelxism. This research aims to understand how digital activism efforts for sustainable tourism are carried out by the Instagram account @travelxism through Voluntrip activity content. The research method employed is qualitative with a case study approach. The research findings indicate that the practice of digital activism in fostering sustainable tourism through Voluntrip activities includes the following: 1) Build a social media account that focuses on environmentally friendly travel by utilizing the feeds, stories, highlights, reels, and mentions features; 2) Implementing the concept of sustainability, which includes volunteerism, charity, news, and visual action; 3) Optimizing visual actions that contain sustainable management, social-economy, culture, and environmental content; 4) Voluntrip content is uploaded regularly 3-4 times a week during prime time.
Event management of Jogja Sunday Ride community in prostate cancer campaign through the distinguished Gentleman's Ride movement in Yogyakarta 2023
Authors: Dewi Laksita Anaura , Sari Sovia Sitta 
Published: November 2023

Jogja Sunday Ride (JSR) community is a social movement that was formed in 2016 through social media. The Jogja Sunday Ride (JSR) community organizes an event called The Distinguished Gentleman's Ride (DGR) once a year, which is a global campaign movement for prostate cancer awareness. In 2023, the JSR Community has successfully organized DGR activities with an increasing number of participants compared to previous years. The increase in the number of participants is one indicator of success in the implementation of the event. The purpose of this research is to find out how the event management of the Jogja Sunday Ride community in the prostate cancer campaign through The Distinguished Gentleman's Ride social movement in Yogyakarta in 2023. This research uses event management theory in its analysis to produce activities that are in line with expectations. This research uses descriptive qualitative research methods using interviews and documentation and analyzes qualitative data, namely data reduction, data presentation and conclusion drawing. The results of this study prove that event management carried out by the Jogja Sunday Ride community shows success factors supported by the process through five stages, namely Research, Design, Planning, Coordination, and Evaluation.KeywordsEvent managementCommunityCampaignProstate Cancer
Content analysis of the Wizardliz “Life lesson from a people pleaser” in improving self esteem
Authors: Khusna Faras Afifatul , Nur Fitrinanda An 
Published: November 2023

Based on bullying or toxic relationship that happen around us which can hit women or men, child or adult and mostly teenagers makes researcher realize that the victims are need something to protect their self, which is self esteem. Related to this background, a youtuber named Liz with her channel “The Wizard liz” made a video titled “Life Lesson from a People Pleaser” that explained to viewers how she struggle through her bullying experience. This study aims to know how Liz can improve her self esteem and escape her struggles from The Wizzardliz content. Researcher used qualitative methods in this study, the data would be pictures or subtitles that showed about the way Liz build her self esteem. To analyzed the data, researcher use self esteem theory from Coopersmith that have four indicators which is successes, aspirations, values, and defenses. For the result, there is statements that revealed of the indicators which is power, acceptance, support, and action that Liz have done and get it from her family to upgrading her self esteem. The conclusion is every individuals need to know about their self esteem, so every individuals can respect their self first without hurting anyone. And they must respect the others too for uphold the human rights.
Giant complex hepatic cyst causing pseudocystitis: A case report
Authors: Li Song , Tang Jie , Ni De-Sheng , Xia A-Dong , Chen Guo-Liang 
Published: November 2023

BACKGROUND
Hepatic cysts are common benign liver tumors that are typically asymptomatic. However, larger cysts, particularly giant liver cysts, can potentially induce symptoms. If the diameter of the cyst exceeds 10 cm, it can exert pressure on adjacent organs, leading to manifestations of corresponding symptoms. Here, we report the case of a complex giant hepatic cyst that caused pseudocystitis.
CASE SUMMARY
A 16-year-old girl was admitted to our hospital with frequent and urgent urination. Ultrasonography revealed no obvious uterine adnexal abnormalities but showed a hypoechoic, cystic mass (173 mm × 84 mm × 138 mm) with clear boundaries, and an unclear blood flow signal in the abdominal cavity (extending from the lower edge of the left lobe of liver to the upper edge of the bladder). Abdominal contrast-enhanced computed tomography revealed a giant cystic mass in the abdominal and pelvic cavities, possibly originating from the liver, and a small amount of free fluid in the pelvic cavity, which subsequent magnetic resonance imaging confirmed. The imaging characteristics were consistent with a benign lesion. The patient underwent laparoscopic resection of the giant liver cyst with partial liver resection. Post-surgery her symptoms urinary symptoms were relieved completely and she was discharged on the sixth postoperative day.
CONCLUSION
Our patient presented with symptoms suggestive of pseudocystitis, stressing the need for considering possibilities of other etiologies and differential diagnoses.
Cerebral proliferative angiopathy in pediatric age presenting as neurological disorders: A case report
Authors: Luo Fu-Ren , Zhou Ying , Wang Zhong , Liu Qi-Yu 
Published: November 2023

BACKGROUND
Cerebral proliferative angiopathy (CPA) is a rare subtype of arteriovenous malformation. It is extremely rare in pediatric patients and has serious implications for developing children. However, reports of these disorders worldwide are limited, and no uniform reference for diagnosis and treatment options exists. We report the case of a 6-year-old with CPA having predominantly neurological dysfunction and review the literature on pediatric CPA.
CASE SUMMARY
We report the case of a pediatric patient with CPA analyzed using digital subtraction angiography (DSA) who presented initially with a neurological disorder as the main manifestation. This case is the basis for further discussion of the clinical presentation, pathogenesis, diagnosis, and treatment of CPA in children. After the cerebral DSA, the patient was treated conservatively with sedation, fluid replacement, and blood anticoagulation. She could not cooperate with the follow-up magnetic resonance imaging examination because of her young age, and her family declined further treatment because of the surgery’s high risk. She was followed up for 3 months; her symptoms did not worsen.
CONCLUSION
This report of rare pediatric CPA can inform and advance clinical research on congenital cerebrovascular diseases.