bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inteligencia Artificial y Auditoría: Tendencias de la literatura científica
Authors: Fajardo Pereira Johana , Toscano Hernández Aníbal , García Alarcón Héctor , Llanos Ayola Jones 
Published: February 2024

Objetivos: La inteligencia artificial se ha establecido como una fuerza disruptiva en una amplia gama de industrias, incluida la auditoría. En la última década, la Inteligencia artificial ha demostrado su capacidad para automatizar tareas, identificar patrones complejos y mejorar la precisión de los procesos de auditoría. El propósito fundamental de este estudio resumir y exponer los estudios científicos de la investigación relacionada con la inteligencia artificial y la auditoría a nivel mundial.
Métodos: Se realizo un análisis bibliométrico que abarca un período de 37 años, desde 1984 hasta 2022. Para analizar y presentar los resultados se utilizó el paquete de análisis bibliométrico Biblioshiny, soportado en el programa R Studio, así como en el software VOSviewer, teniendo en cuenta 306 artículos y revisiones de literatura. Este enfoque cuantitativo nos permitió identificar patrones y tendencias en la investigación.
Resultados: Los resultados reflejan cambios importantes en el número de publicaciones anuales al registrar que el 70,91% de los documentos se publicaron en los últimos 7 años (2016 a 2022) y solo el 29,08% fue publicado en los 30 años comprendidos entre 1984 y 2015. Además, entre las 234 revistas científicas con publicaciones relacionadas, se identifican las ocho principales que concentran un 12.8% de las publicaciones y acumulan 12.5% de las citaciones. El clúster más numeroso, representado en color rojo, resaltando los 10 principales “audit”, “Audit Quality”, “Auditing”, “Big Data”, “Big Data Analytics”, “Blockchain”, “Computers”, “Data Mining”, “Decision Making”.
Conclusión: Esta investigación permite caracterizar la producción científica relacionada con la inteligencia artificial y la auditoria considerando la evolución temporal, características generales, redes de investigación con autores e instituciones, así como los clústeres temáticos de mayor relevancia en este campo de estudio.
Pengendalian Persediaan Obat Generik Berlogo Berdasarkan Analisis Metode ABC, Economic Order Quantity (EOQ), dan Reorder Point (ROP) di Instalasi Farmasi RS “X” Kota Palopo
Authors: Magfirah Andi , Ervianingsih Ervianingsih , Samsi Al Syahril 
Published: February 2024

Pengendalian persediaan merupakan fungsi manajerial yang sangat penting karena pada persediaan fisik biasanya banyak perusahaan melibatkan investasi rupiah terbesar dalam pos aktiva lancar. Pengendalian persediaan pada obat generik dapat digunakan analisa ABC dalam pengelompokan suatu jenis barang, analisis EOQ (Economic Order Quantity)untuk menentukan jumlah pemesanan yang tepat, dan ROP (Reorder Point)untuk mengetahui waktu pemesanan kembali. Tujuan dari penelitian ini adalah untuk mengetahui dan memastikan pengendalian persediaan dan pengelompokan obat berdasarkan metode yang ABC, EOQ dan ROP. Metode penelitian yaitu kualitatif deskriptif yaitu menggunakan data dari RS “X” Kota Palopo dan wawancara mendalam dan melakukan observasi atau pengamatan langsung dengan metode analisis ABC, EOQ, dan ROP pada bulan september sampai november 2022. Hasil dari penelitian menunjukan perhitungan analisis ABC obat generik termasuk kelompok A adalah 5% diseluruh persediaan dengan nilai investasi 71 %, kelompok B sebanyak 20% diseluruh obat dengan nilai investasi 20%, dan kelompok C 9% dari total investasi di Instalasi Farmasi RS “X” Kota Palopo. Dalam EOQ, obat Dexketoprofen 50 Mg Per 2 Ml Amp yang optimum adalah 611 unit. Jumlah pemesanan optimum 867 jenis obat yaitu memiliki variasi berbeda untuk jenis obat. Berdasarkan perhitungan ROP didapatkan titik melakukan pemesanan kembali untuk 43 jenis obat kategori kelas A memiliki variasi berbeda-beda mulai dari 0,71 hingga 1033, untuk setiap jenis obat.
Pengaruh Terapi Musik Terhadap Penurunan Gejala pada Pasien Gangguan Jiwa dengan Resiko Perilaku Kekerasan
Authors: Faruk Ibrahim Dwi Agustian 
Published: February 2024

Gangguan jiwa adalah sekumpulan gejala yang ditandai dengan adanya perubahan perilaku, salah satu perubahan perilaku yang berbahaya adalah resiko perilaku kekerasan. Perilaku kekerasan dapat dicegah dengan menerapkan tindakan keperawatan yang telah dirumuskan. Terapi musik merupakan salah satu terapi komplementer. Terapi komplementer merupakan pelengkap dari terapi utama, sehingga dengan adanya terapi komplementer yang diberikan bersamaan kepada pasien diharapkan membantu mempercepat keberhasilan terapi utama. Penelitiaan ini bertujuan untuk mencari tahu seberapa efektif terapi musik dalam membantu intervensi utama pada masalah resiko perilaku kekerasan. Penelitian ini menggunakan metode literature review, penelitian ini menganalisa 7 artikel yang telah memenuhi kriteria inklusi setelah sebelumnya dilakukan pencarian pada portal pencarian artikel. Hasil penelitian meunjukkan bahwa dari 7 artikel mayoritas menggunakan pendekatan studi kasus yang dilakukan pada 1 – 5 responden. Dari seluruh artikel didapatkan bahwa terapi musik sangat cepat dalam membantu menurunkan gejala pada masalah resiko perilaku kekerasan. resiko perilaku kekerasan yang sangat membahayakan bagi pasien maupun lingkungannya dapat di cegah dengan menurunkan gejalanya, dalam upaya tersebut diperlukan rencana tindakan yang sesuai. Tindakan utama yang dilakukan bersamaan dengan terapi musik menjadi sangat efektid dan mempercepat penurunan gejala pada pasien gangguan jiwa dengan resiko perilaku kekerasan.
Pengetahuan Keluarga Terhadap Pemanfaatan Tanaman Obat Keluarga (TOGA) Untuk Meningkatkan Kesehatan Fisik Lansia di Desa Cipancar Kecamatan Sumedang Selatan
Authors: Nurbaeti Ira Apriani , Dolifah Dewi , Hoedaya Ahmad Purnama 
Published: February 2024

Pemeliharaan kesehatan dapat dilakukan melalui pemanfaatan tanaman obat yang memiliki banyak khasiat. Kesehatan lansia yang rentan mengalami masalah kesehatan memerlukan perhatian penting dari keluarga. Penelitian ini bertujuan mengetahui gambaran pengetahuan keluargaterhadap pemanfaatan tanmaan obat keluarga (TOGA) untuk meningkatkan kesehatan fisik lansia. Desain penelitian yang digunakan adalah deskriptif kuantitatif dengan pendekatan cross sectional. Jumlah sampel sebanyak 37 responden dengan teknik total sampel. Kriteria inklusi dalam studi ini adalah keluarga dengan lansia diatas 60 tahun, tanaman obat keluarga (TOGA) yang diteliti adalah jenis rimpang dan daun serta keluarga dengan lansia yang berada di luar daerah sebagai kriteria eksklusi. Analisis univariat data kategorik menggunakan presentase dan distribusi frekuensi. Penelitian menunjukkan hasil, pengetahuan keluarga terhadap pemanfaatan TOGA untuk meningkatkan kesehatan fisik lansia adalah keluarga yang memiliki pengetahuan kurang sebanyak 54,05%, berpengetahuan cukup sebanyak 35,14% dan keluarga yang memiliki pengetahuan baik sebanyak 10,81%. Pengetahuan keluarga tentang pemanfaatan TOGA sebagian besar mengetahui sebagai upaya penyembuhan (kuratif) sebanyak 78,38% dan sebagai upaya pencegahan pencegahan (preventif) sebanyak 21,62. Sebagian besar masyarakat telah menanam tanaman obat keluarga (TOGA) namun pengetahuan pemanfaatan TOGA untuk meningkatkan kesehatan fisik lansia masih kurang.
Bichronous scientific writing course for medical faculty during Covid-19: a SWOT analysis experience
Authors: Khojasteh Laleh , Zarifsanaiey Nahid , Karimian Zahra 
Published: February 2024

IntroductionWriting and publishing scholarly articles in international peer-reviewed journals can be a challenging undertaking for medical and healthcare professionals in universities, especially in non-English speaking countries. Surprisingly, very few faculty members report receiving guidance on scientific writing. To encourage more faculty engagement in professional development courses aimed at enhancing their writing abilities, we have revamped scientific writing courses to incorporate bichronous (a combination of asynchronous and synchronous) teaching methods.MethodsAfter forming a team, we performed a SWOT (strengths, weaknesses, opportunities, and threats) study of the medical faculty’s present programs and proposed alternatives to prior course issues. In this interventional study, fifty-nine eligible medical educators selected by purposeful sampling underwent a two-and-a-half-month bichronous scientific writing course from March to August 2021. The perspectives of the participants were evaluated through a SWOT analysis. The data were collected through online semi-structured interviews, and data collection continued until data saturation was achieved (40 participants). Data were then coded and analyzed based on conventional qualitative content analysis principles.ResultsOur planned blending sequence and e-feedback increased the medical faculty’s drive to learn, self-confidence, and autonomy while improving their writing skills. Poor ICT and network infrastructure hindered course adoption. Due to the course’s time and the faculty’s own online teaching, many battled with computer vision syndrome, self-discipline, and distractions. Our participants struggled with self-discipline and distractions, so setting a daily time limit may help them concentrate.DiscussionGiven the faculty’s demanding professional lives, this designed course provided a learning opportunity for many that would not have been feasible otherwise.
Early-phase insulin secretion during mixed-meal tolerance testing predicts β-cell function and secretory capacity in cystic fibrosis
Authors: Sheikh Saba , Stefanovski Darko , Kilberg Marissa J. , Hadjiliadis Denis , Rubenstein Ronald C. , Rickels Michael R. , Kelly Andrea 
Published: February 2024

Insulin secretion within 30 minutes of nutrient ingestion is reduced in people with cystic fibrosis (PwCF) and pancreatic insufficiency and declines with worsening glucose tolerance. The glucose potentiated arginine (GPA) test is validated for quantifying β-cell secretory capacity as an estimate of functional β-cell mass but requires technical expertise and is burdensome. This study sought to compare insulin secretion during mixed-meal tolerance testing (MMTT) to GPA-derived parameters in PwCF.MethodsSecondary data analysis of CF-focused prospective studies was performed in PwCF categorized as 1) pancreatic insufficient [PI-CF] or 2) pancreatic sufficient [PS-CF] and in 3) non-CF controls. MMTT: insulin secretory rates (ISR) were derived by parametric deconvolution using 2-compartment model of C-peptide kinetics, and incremental area under the curve (AUC) was calculated for 30, 60 and 180-minutes. GPA: acute insulin (AIR) and C-peptide responses (ACR) were calculated as average post-arginine insulin or C-peptide response minus pre-arginine insulin or C-peptide under fasting (AIRarg and ACRarg), ~230 mg/dL (AIRpot and ACRpot), and ~340 mg/dL (AIRmax and ACRmax) hyperglycemic clamp conditions. Relationships of MMTT to GPA parameters were derived using Pearson’s correlation coefficient. Predicted values were generated for MMTT ISR and compared to GPA parameters using Bland Altman analysis to assess degree of concordance.Results85 PwCF (45 female; 75 PI-CF and 10 PS-CF) median (range) age 23 (6-56) years with BMI 23 (13-34) kg/m2, HbA1c 5.5 (3.8-10.2)%, and FEV1%-predicted 88 (26-125) and 4 non-CF controls of similar age and BMI were included. ISR AUC30min positively correlated with AIRarg (r=0.55), AIRpot (r=0.62), and AIRmax (r=0.46) and with ACRarg (r=0.59), ACRpot (r=0.60), and ACRmax (r=0.51) (all P&lt;0.001). ISR AUC30min strongly predicted AIRarg (concordance=0.86), AIRpot (concordance=0.89), and AIRmax (concordance=0.76) at lower mean GPA values, but underestimated AIRarg, AIRpot, and AIRmax at higher GPA-defined β-cell secretory capacity. Between test agreement was unaltered by adjustment for study group, OGTT glucose category, and BMI.ConclusionEarly-phase insulin secretion during MMTT can accurately predict GPA-derived measures of β-cell function and secretory capacity when functional β-cell mass is reduced. These data can inform future multicenter studies requiring reliable, standardized, and technically feasible testing mechanisms to quantify β-cell function and secretory capacity.
Two-stage low-carbon optimal dispatch of the power system considering demand response to defend large uncertainties and risks
Authors: Cai Linjun , Xie Dongliang , Xue Feng , Zhang Huilin 
Published: February 2024

Introduction: In order to promote the consumption of renewable energy, reduce carbon emissions, and take into account the uncertainty of renewable energy output and load fluctuations in the new power system that can affect the normal operation of market mechanism, a two-stage low-carbon optimization scheduling method for power system that considers demand response under multiple uncertainties is proposed in this paper.Methods: Uncertain scene sets are generated through Latin hypercube sampling and heuristic synchronous backpropagation method is used to reduce scenes to obtain typical scenes and their probabilities. Then, a one-stage optimization model is established with the goal of maximizing energy efficiency and corresponding demand response strategies are obtained. Green certificate carbon trading joint mechanism model consisting of tiered green certificate trading and time-sharing tiered carbon trading are established, and the output of two-stage units are optimized with the goal of minimizing comprehensive operating costs.Result: The simulation results show that the carbon emissions are decreased by 251.57 tons, the consumption rate of renewable energy is increased by 8.64%, and the total costs are decreased by 124.0612 million yuan.Discussion: From this, it can be seen that the dual layer low-carbon optimization scheduling strategy for power system considering demand response under multiple uncertainties can effectively reduce the operating costs and carbon emissions of the system, while balancing the economic and environmental aspects of power system operation.
The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol
Authors: Lentilhas-Graça José , Santos Diogo J. , Afonso João , Monteiro Andreia , Pinho Andreia G. , Mendes Vera M. , Dias Marta S. , Gomes Eduardo D. , Lima Rui , Fernandes Luís S. , Fernandes-Amorim Fernando , Pereira Inês M. , de Sousa Nídia , Cibrão Jorge R. , Fernandes Aline M. , Serra Sofia C. , Rocha Luís A. , Campos Jonas , Pinho Tiffany S. , Monteiro Susana , Manadas Bruno , Salgado António J. , Almeida Ramiro D. , Silva Nuno A. 
Published: February 2024

IntroductionThe inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one of the reasons why macrophage transplantation has failed.MethodsIn this study, we investigated the therapeutic potential of the macrophage secretome for SCI recovery. We investigated the effect of the secretome in vitro using peripheral and CNS-derived neurons and human neural stem cells. Moreover, we perform a pre-clinical trial using a SCI compression mice model and analyzed the recovery of motor, sensory and autonomic functions. Instead of transplanting the cells, we injected the paracrine factors and extracellular vesicles that they secrete, avoiding the loss of the phenotype of the transplanted cells due to local environmental cues.ResultsWe demonstrated that different macrophage phenotypes have a distinct effect on neuronal growth and survival, namely, the alternative activation with IL-10 and TGF-β1 (M(IL-10+TGF-β1)) promotes significant axonal regeneration. We also observed that systemic injection of soluble factors and extracellular vesicles derived from M(IL-10+TGF-β1) macrophages promotes significant functional recovery after compressive SCI and leads to higher survival of spinal cord neurons. Additionally, the M(IL-10+TGF-β1) secretome supported the recovery of bladder function and decreased microglial activation, astrogliosis and fibrotic scar in the spinal cord. Proteomic analysis of the M(IL-10+TGF-β1)-derived secretome identified clusters of proteins involved in axon extension, dendritic spine maintenance, cell polarity establishment, and regulation of astrocytic activation.DiscussionOverall, our results demonstrated that macrophages-derived soluble factors and extracellular vesicles might be a promising therapy for SCI with possible clinical applications.
Pulmonary inflammation decreases with ultra-protective ventilation in experimental ARDS under VV-ECMO: a positron emission tomography study
Authors: Deniel Guillaume , Dhelft François , Lancelot Sophie , Orkisz Maciej , Roux Emmanuel , Mouton William , Benzerdjeb Nazim , Richard Jean-Christophe , Bitker Laurent 
Published: February 2024

BackgroundExperimentally, ultra-protective ventilation (UPV, tidal volumes [VT] &lt; 4 mL.kg−1) strategies in conjunction with veno-venous extracorporeal membrane oxygenation (VV-ECMO) are associated with lesser ventilator-induced lung injuries (VILI) during acute respiratory distress syndrome (ARDS). However, whether these strategies reduce lung inflammation more effectively than protective ventilation (PV) remains unclear. We aimed to demonstrate that a UPV strategy decreases acute lung inflammation in comparison with PV in an experimental swine model of ARDS.MethodsARDS was induced by tracheal instillation of chlorhydric acid in sedated and paralyzed animals under mechanical ventilation. Animals were randomized to receive either UPV (VT 1 mL.kg−1, positive end-expiration pressure [PEEP] set to obtain plateau pressure between 20 and 25 cmH2O and respiratory rate [RR] at 5 min−1 under VV-ECMO) or PV (VT 6 mL.kg−1, PEEP set to obtain plateau pressure between 28 and 30 cmH2O and RR at 25 min−1) during 4 h. After 4 h, a positron emission tomography with [11C](R)-PK11195 (ligand to TSPO-bearing macrophages) injection was realized, coupled with quantitative computerized tomography (CT). Pharmacokinetic multicompartment models were used to quantify regional [11C](R)-PK11195 lung uptake. [11C](R)-PK11195 lung uptake and CT-derived respiratory variables were studied regionally across eight lung regions distributed along the antero-posterior axis.ResultsFive pigs were randomized to each study group. Arterial O2 partial pressure to inspired O2 fraction were not significantly different between study groups after experimental ARDS induction (75 [68–80] mmHg in a PV group vs. 87 [69–133] mmHg in a UPV group, p = 0.20). Compared to PV animals, UPV animals exhibited a significant decrease in the regional non-aerated compartment in the posterior lung levels, in mechanical power, and in regional dynamic strain and no statistical difference in tidal hyperinflation after 4 h. UPV animals had a significantly lower [11C](R)-PK11195 uptake, compared to PV animals (non-displaceable binding potential 0.35 [IQR, 0.20–0.59] in UPV animals and 1.01 [IQR, 0.75–1.59] in PV animals, p = 0.01). Regional [11C](R)-PK11195 uptake was independently associated with the interaction of regional tidal hyperinflation and regional lung compliance.ConclusionIn an experimental model of ARDS, 4 h of UPV strategy significantly decreased lung inflammation, in relation to the control of VT-derived determinants of VILI.
Exploring the secrets of virus entry: the first respiratory syncytial virus carrying beta lactamase
Authors: De Ávila-Arias Marcio , Villarreal-Camacho Jose Luis , Cadena-Cruz Christian , Hurtado-Gómez Leidy , Costello Heather M. , Rodriguez Alexander , Burgos-Florez Francisco , Bettin Alfonso , Kararoudi Meisam Naeimi , Muñoz Amner , Peeples Mark E. , San-Juan-Vergara Homero 
Published: February 2024

BackgroundRespiratory Syncytial Virus (RSV) presents a significant health threat, especially to young children. In-depth understanding of RSV entry mechanisms is essential for effective antiviral development. This study introduces an innovative RSV variant, featuring the fusion of the beta-lactamase (BlaM) enzyme with the RSV-P phosphoprotein, providing a versatile tool for dissecting viral entry dynamics.MethodsUsing the AlphaFold2 algorithm, we modeled the tertiary structure of the P-BlaM chimera, revealing structural similarities with both RSV-P and BlaM. Functional assessments, utilizing flow cytometry, quantified beta-lactamase activity and GFP expression in infected bronchial epithelial cells. Western blot analysis confirmed the integrity of P-BlaM within virions.ResultsThe modeled P-BlaM chimera exhibited structural parallels with RSV-P and BlaM. Functional assays demonstrated robust beta-lactamase activity in recombinant virions, confirming successful P-BlaM incorporation as a structural protein. Quercetin, known for its antiviral properties, impeded viral entry by affecting virion fusion. Additionally, Ulixertinib, an ERK-1/2 inhibitor, significantly curtailed viral entry, implicating ERK-1/2 pathway signaling.ConclusionsOur engineered RSV-P-BlaM chimera emerges as a valuable tool, illuminating RSV entry mechanisms. Structural and functional analyses unveil potential therapeutic targets. Quercetin and Ulixertinib, identified as distinct stage inhibitors, show promise for targeted antiviral strategies. Time-of-addition assays pinpoint quercetin’s specific interference stage, advancing our comprehension of RSV entry and guiding future antiviral developments.