bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hillslope and vegetation response to postglacial warming at Bear Meadows Bog, Pennsylvania, USA
Authors: Del Vecchio Joanmarie , Ivory Sarah J. , Mount Gregory J. , Leddy Matthew , DiBiase Roman A. 
Published: January 2024

AbstractConnecting changes in erosion and vegetation is necessary for predicting topographic and ecologic change in thawing permafrost landscapes. Formerly periglacial landscapes serve as potential analogs for understanding modern permafrost landscape change, yet compared to paleoenvironmental records at these sites, less is known about concurrent geomorphic processes, particularly their rates and relationships to climate change. Here, we target sediments preserved in a central Appalachian peat bog to reconstruct sedimentation across the last deglacial warming. We use ground-penetrating radar and geochemistry of cored bog sediments to quantify sedimentation timing, style, and provenance. Using14C dating of sedimentary and geochemical shifts, we connect depositional changes to global climate and local vegetation change. We show that deglacial warming promoted deep soil disturbances via solifluction at ca. 14 ka. In contrast, relatively wetter conditions from ca. 10–9 ka promoted shallow disturbance of hillslopes via slopewash, which corresponds to a time of vegetation change. Our results highlight climate-modulated erosion depth and processes in periglacial and post-periglacial landscapes. The existence of similar erosion and vegetation records preserved regionally implies these dynamics were pervasive across unglaciated Appalachian highlands, aiding in reconstructing erosion responses to warming at a resolution with implications for predicting high-latitude landscape responses to disturbance.
Linking the impact of seismicity on palaeogeographic evolution and sedimentary architecture: A case study from Middle Jurassic succession of Spiti Himalaya
Authors: Mandal Sabyasachi , Singh Abha , Banerjee Santanu , Uddandam Premraj , Negi Ranveer Singh 
Published: January 2024

AbstractThe traces left by earthquakes in the unlithified sediments, recorded as soft-sediment deformation structures (SSDS), are well reconstructed as palaeo-seismic signals, while the origin of SSDS, seismic vs. Aseismic, is challenging. The present study discusses the origin of SSDS and its implications on palaeoceanography and sediment architecture. In the Middle Jurassic succession of Spiti Himalayan region in India, the topmost part of the Ferruginous Oolitic Formation (FOF) consists of four layers of SSDS and is underlain by the lower member of the Spiti Formation (SF). The sedimentary facies analysis documents the palaeogeographic shift from the middle shelf (carbonate-shale repository: FOF) to the outer shelf (black shale: lower member of SF). The SSDS layers, exhibiting load casts, ball and pillow structures, indicate gravitational instability, while syn-sedimentary faults and insitu breccia are the results of brittle deformation. The dominance of storms in depositional sites often argues for a possible triggering agent for SSDS. Therefore, it was necessary to distinguish between seismic vs. aseismic triggering agents. The lateral continuity, vertical repetition, confinement of SSDS at the top part of FOF and sharp change of facies assemblage indicate seismicity-induced syn-sediment deformation, i.e. seismite. The transition from middle shelf to outer shelf at the onset of seismite indicates that seismic impact possibly caused the rapid subsidence, resulting in the palaeogeographic shift. The rapid transgression is recorded as carbonate-shale repository to anoxic black shale. This study highlights the importance of sedimentological analysis to distinguish the seismite and its implications on palaeogeographic evolution and sedimentary architecture.
The Moriscos of Salé and the Hispanic Monarchy: Power Agents and Identities to the West of the Strait of Gibraltar, 1631–1632
Authors: Salas Almela Luis 
Published: January 2024

AbstractThis article examines the multiple frontiers between Maghrebi Islam and the southern European Catholic world by focusing on a very specific episode during the struggle for control of Rabat, capital of present-day Morocco. It addresses the problem of military and political control of the Strait of Gibraltar, which was closely linked to widespread corsair raids in the early seventeenth century. It also examines moriscos’ attempts to be allowed to return to Spain. The article points to the key importance of intermediaries and their linkages across borders at a time when both the Hispanic Monarchy and the Sa’adi kingdom were undergoing great difficulties. The strategic importance of the region transformed moments of crisis into opportunities, albeit failed ones, as intermediaries articulated their own interests with those of the king of Spain.
Evaluation of the antiparasitic and antifibrotic effects of gallic acid on experimental hepatic schistosomiasis mansoni
Authors: Sharaf-El-Deen S. , Soliman S. , Brakat R. 
Published: January 2024

Abstract
Schistosomiasis afflicts approximately 120 million individuals globally. The hepatic pathology that occurs due to egg-induced granuloma and fibrosis is commonly attributed to this condition. However, there is currently no efficacious treatment available for either of these conditions.
Our study aimed to investigate the potential antifibrotic and antiparasitic properties of different doses of gallic acid (GA) in experimental schistosomiasis mansoni. In addition, we investigated the outcomes of co-administering it with the standard anti-schistosomiasis treatment, praziquantel (PZQ).
In experiment I, Schistosoma mansoni-infected mice were administered GA at doses of 10, 20, or 40 mg/kg. Their effectiveness was evaluated through parasitological (worm and egg loads, granuloma number and diameter), pathological (fibrosis percentage and H-score of hepatic stellate cells (HSCs)), and functional (liver enzymes) tests. In experiment II, we investigated the optimal dosage that yielded the best outcomes. This dosage was administered in conjunction with PZQ and was evaluated regarding the parasitological, pathological, functional, and immunological (fibrosis-regulating cytokines) activities.
Our findings indicate that the administration of 40 mg/kg GA exhibited the highest level of effectiveness in experiment I. In experiment II, it exhibited lower antiparasitic efficacy in comparison to PZQ. However, it surpassed PZQ in other tests. It showed enhanced outcomes when combined with PZQ.
In conclusion, our findings reveal that GA only slightly increased the antischistosomal activity of PZQ. However, it was linked to decreased fibrosis, particularly when administrated with PZQ. Our pilot study identifies GA as a natural antifibrotic agent, which could be administered with PZQ to mitigate the development of fibrosis.
A Harrean perspective of theology
Authors: Recio Gonzalo L. 
Published: January 2024

Abstract
The object of this article is to present Christian theology as a case of a Harrean theory, as a mapping which links the members of one set of entities to those of another in a systematic way. I will divide the article into four parts. The first one will be devoted to a brief presentation of the main characteristics of Harré's proposal. Once the fundamentals of the Harrean perspective are presented, the second section will be the presentation of Christian theology as a case of a Harrean theory. The third and fourth sections are concerned with showing how two classic theological topics, conversion and prophecy, can be framed within this perspective in a cohesive and fruitful way.
Overview of climate disclosures
Authors: Dey D. , Richards L. , Arora M. , Boyle E. , Bryson R. , Jackman S. , Patel V. , Shirazi C. 
Published: January 2024

Abstract
Climate change is at the forefront of discussions for many companies. Climate change-related disclosures and reporting are important tools and allow stakeholders to understand climate-related risks a company is facing and help various stakeholders to take informed decisions.
The landscape for climate change-related reporting requirements is ever evolving, with a trend from voluntary to mandatory, with many global disclosure standards and requirements influencing local requirements and other related standards.
This paper explores these ideas further, giving a general background to disclosure requirements, discusses greenwashing, details disclosure organisations including TCFD and the ISSB, and provides details on a country level including green taxonomies.
Ilulissat Icefjord Upper‐Layer Circulation Patterns Revealed Through GPS‐Tracked Icebergs
Authors: Baratta Sydney J. N. , Schild Kristin M. , Sutherland David A. 
Published: January 2024

AbstractThe Greenland Ice Sheet has undergone rapid mass loss over the last four decades, primarily through solid and liquid discharge at marine‐terminating outlet glaciers. The acceleration of these glaciers is in part due to the increase in temperature of ocean water in contact with the glacier terminus. However, quantifying heat transport to the glacier through fjord circulation can be challenging due to iceberg abundance, which threatens instrument survival and fjord accessibility. Here we utilize iceberg movement to infer upper‐layer fjord circulation, as freely floating icebergs (i.e., outside the mélange region) behave as natural drifters. In the summers of 2014 and 2019, we deployed transmitting GPS units on a total of 13 icebergs in Ilulissat Icefjord, an iceberg‐rich and historically data‐poor fjord in west Greenland, to quantify circulation over the upper 0–250 m of the water column. We find that the direction of upper‐layer fjord circulation is strongly impacted by the timing of tributary meltwater runoff, while the speed of this circulation changes in concert with glacier behavior, which includes increases and decreases in glacier speed and meltwater runoff. During periods of increased meltwater runoff entering from tributary fjords, icebergs at these confluences deviated from their down‐fjord trajectory, even reversing up‐fjord, until the runoff pulse subsided days later. This study demonstrates the utility of iceberg monitoring to constrain upper‐layer fjord circulation, and highlights the importance of including tributary fjords in predictive models of heat transport and fjord circulation.
Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
Authors: Kays Mohammed Ali Younes , Dolin Troels Gammeltoft , Damm Nybing Janus , Lykke Jakob , Hvid Linden Frederik , Høgh-Schmidt Erik , Sørensen Thorkild I. A. , Christensen Jesper Frank , Nielsen Yousef J. W. , Stenfatt Larsen Jim , Madsbad Sten , Sidenius Johansen Julia , Svane Maria Saur , Lang Lehrskov Louise 
Published: January 2024

Abstract
Background
Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots.

Material and methods
Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately.

Results
A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2–9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2–6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2–7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4–9%, p < 0.001) increase in SAT and a 4% (95% CI: 1–7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2–10%, p < 0.01) after 3 years.

Conclusion
After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT.
A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease
Authors: Kim Su-Jeong , Miller Brendan , Hartel Nicolas G. , Ramirez Ricardo , Braniff Regina Gonzalez , Leelaprachakul Naphada , Huang Amy , Wang Yuzhu , Arpawong Thalida Em , Crimmins Eileen M. , Wang Penglong , Sun Xianbang , Liu Chunyu , Levy Daniel , Yen Kelvin , Petzinger Giselle M. , Graham Nicholas A. , Jakowec Michael W. , Cohen Pinchas 
Published: January 2024

AbstractMitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of developing Parkinson’s disease (PD), yet the underlying mechanisms remain elusive. In this study, we investigate the functional role of a PD-associated mtSNP that impacts the mitochondrial-derived peptide (MDP) Small Humanin-like Peptide 2 (SHLP2). We identify m.2158 T > C, a mtSNP associated with reduced PD risk, within the small open reading frame encoding SHLP2. This mtSNP results in an alternative form of SHLP2 (lysine 4 replaced with arginine; K4R). Using targeted mass spectrometry, we detect specific tryptic fragments of SHLP2 in neuronal cells and demonstrate its binding to mitochondrial complex 1. Notably, we observe that the K4R variant, associated with reduced PD risk, exhibits increased stability compared to WT SHLP2. Additionally, both WT and K4R SHLP2 show enhanced protection against mitochondrial dysfunction in in vitro experiments and confer protection against a PD-inducing toxin, a mitochondrial complex 1 inhibitor, in a mouse model. This study sheds light on the functional consequences of the m.2158 T > C mtSNP on SHLP2 and provides insights into the potential mechanisms by which this mtSNP may reduce the risk of PD.
Alterations of serum neuropeptide levels and their relationship to cognitive impairment and psychopathology in male patients with chronic schizophrenia
Authors: Sun Wenxi , Jin Tingting , Yang Haidong , Li Jin , Tian Qing , Gao Ju , Peng Ruijie , Zhang Guangya , Zhang Xiaobin 
Published: January 2024

AbstractSerum neuropeptide levels may be linked to schizophrenia (SCZ) pathogenesis. This study aims to examine the relation between five serum neuropeptide levels and the cognition of patients with treatment-resistant schizophrenia (TRS), chronic stable schizophrenia (CSS), and in healthy controls (HC). Three groups were assessed: 29 TRS and 48 CSS patients who were hospitalized in regional psychiatric hospitals, and 53 HC. After the above participants were enrolled, we examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the blood serum levels of α-melanocyte stimulating hormone (α-MSH), β-endorphin (BE), neurotensin (NT), oxytocin (OT) and substance.P (S.P). Psychiatric symptoms in patients with SCZ were assessed with the Positive and Negative Syndrome Scale. SCZ patients performed worse than HC in total score and all subscales of the RBANS. The levels of the above five serum neuropeptides were significantly higher in SCZ than in HC. The levels of OT and S.P were significantly higher in CSS than in TRS patients. The α-MSH levels in TRS patients were significantly and negatively correlated with the language scores of RBANS. However, the BE and NT levels in CSS patients were significantly and positively correlated with the visuospatial/constructional scores of RBANS. Moreover, the interaction effect of NT and BE levels was positively associated with the visuospatial/constructional scores of RBANS. Therefore, abnormally increased serum neuropeptide levels may be associated with the physiology of SCZ, and may cause cognitive impairment and psychiatric symptoms, especially in patients with TRS.
Host genetic regulation of human gut microbial structural variation
Authors: Zhernakova Daria V. , Wang Daoming , Liu Lei , Andreu-Sánchez Sergio , Zhang Yue , Ruiz-Moreno Angel J. , Peng Haoran , Plomp Niels , Del Castillo-Izquierdo Ángela , Gacesa Ranko , Lopera-Maya Esteban A. , Temba Godfrey S. , Kullaya Vesla I. , van Leeuwen Sander S. ,   Lifelines Cohort Study, Aguirre-Gamboa Raul , Deelen Patrick , Franke Lude , Kuivenhoven Jan A. , Nolte Ilja M. , Sanna Serena , Snieder Harold , Swertz Morris A. , Visscher Peter M. , Vonk Judith M. , Xavier Ramnik J. , de Mast Quirijn , Joosten Leo A. B. , Riksen Niels P. , Rutten Joost H. W. , Netea Mihai G. , Sanna Serena , Wijmenga Cisca , Weersma Rinse K. , Zhernakova Alexandra , Harmsen Hermie J. M. , Fu Jingyuan 
Published: January 2024

AbstractAlthough the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established1–6, little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a meta-analysis of associations between human genetic variation and gut microbial structural variation in 9,015 individuals from four Dutch cohorts. Strikingly, the presence rate of a structural variation segment in Faecalibacterium prausnitzii that harbours an N-acetylgalactosamine (GalNAc) utilization gene cluster is higher in individuals who secrete the type A oligosaccharide antigen terminating in GalNAc, a feature that is jointly determined by human ABO and FUT2 genotypes, and we could replicate this association in a Tanzanian cohort. In vitro experiments demonstrated that GalNAc can be used as the sole carbohydrate source for F. prausnitzii strains that carry the GalNAc-metabolizing pathway. Further in silico and in vitro studies demonstrated that other ABO-associated species can also utilize GalNAc, particularly Collinsella aerofaciens. The GalNAc utilization genes are also associated with the host’s cardiometabolic health, particularly in individuals with mucosal A-antigen. Together, the findings of our study demonstrate that genetic associations across the human genome and bacterial metagenome can provide functional insights into the reciprocal host–microbiome relationship.
Effects of photoperiod and food on glucose intolerance and subsequent ocular pathology in the fat sand rat
Authors: Bilu Carmel , Butensky Neta , Malamud Amit Richter , Einat Haim , Zimmet Paul , Zloto Ofira , Ziv Hana , Kronfeld-Schor Noga , Vishnevskia-Dai Vicktoria 
Published: January 2024

AbstractType 2 diabetes mellitus (T2DM) and its ocular complications, such as cataract and diabetic retinopathy (DR) have been linked to circadian rhythm-disturbances. Using a unique diurnal animal model, the sand rat (Psammomys obesus) we examined the effect of circadian disruption by short photoperiod acclimation on the development of T2DM and related ocular pathologies. We experimented with 48 male sand rats. Variables were day length (short photoperiod, SP, vs. neutral photoperiod NP) and diet (standard rodent diet vs. low-energy diet). Blood glucose, the presence of cataract and retinal pathology were monitored. Histological slides were examined for lens opacity, retinal cell count and thickness. Animals under SP and fed standard rodent diet (SPSR) for 20 weeks had higher baseline blood glucose levels and lower glucose tolerance compared with animals kept under NP regardless of diet, and under SP with low energy diet (SPLE). Animals under SPSR had less cells in the outer nuclear layer, a lower total number of cells in the retina, and a thickened retina. Higher blood glucose levels correlated with lower number of cells in all cellular layers of the retina and thicker retina. Animals under SPSR had higher occurrence of cataract, and a higher degree of cataract, which correlated with higher blood glucose levels. Sand rats kept under SPSR develop cataract and retinal abnormalities indicative of DR, whereas sand rats kept under NP regardless of diet, or under SPLE, do not. These ocular abnormalities significantly correlate with hyperglycemia.
Investigating seasonal air quality variations consequent to the urban vegetation in the metropolis of Faisalabad, Pakistan
Authors: Sabir Muhammad Azeem , Nawaz Muhammad Farrakh , Khan Tanveer Hussain , Zulfiqar Usman , Haider Fasih Ullah , Rehman Abdul , Ahmad Irfan , Rasheed Fahad , Gul Sadaf , Hussain Safdar , Iqbal Rashid , Chaudhary Talha , Mustafa Abd El-Zaher M. A. , Elshikh Mohamed S. 
Published: January 2024

AbstractUrban atmospheric pollution is global problem and and have become increasingly critical in big cities around the world. Issue of toxic emissions has gained significant attention in the scientific community as the release of pollutants into the atmosphere rising continuously. Although, the Pakistani government has started the Pakistan Clean Air Program to control ambient air quality however, the desired air quality levels are yet to be reached. Since the process of mapping the dispersion of atmospheric pollutants in urban areas is intricate due to its dependence on multiple factors, such as urban vegetation and weather conditions. Therefore, present research focuses on two essential items: (1) the relationship between urban vegetation and atmospheric variables (temperature, relative humidity (RH), sound intensity (SI), CO, CO2, and particulate matter (PM0.5, PM1.0, and PM2.5) and (2) the effect of seasonal change on concentration and magnitude of atmospheric variables. A geographic Information System (GIS) was utilized to map urban atmospheric variables dispersion in the residential areas of Faisalabad, Pakistan. Pearson correlation and principal component analyses were performed to establish the relationship between urban atmospheric pollutants, urban vegetation, and seasonal variation. The results showed a positive correlation between urban vegetation, metrological factors, and most of the atmospheric pollutants. Furthermore, PM concentration showed a significant correlation with temperature and urban vegetation cover. GIS distribution maps for PM0.5, PM1.0, PM2.5, and CO2 pollutants showed the highest concentration of pollutants in poorly to the moderated vegetated areas. Therefore, it can be concluded that urban vegetation requires a rigorous design, planning, and cost–benefit analysis to maximize its positive environmental effects.