bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Authors: Raulin Ana-Caroline , Doss Sydney V. , Heckman Michael G. , Craver Emily C. , Li Zonghua , Ikezu Tadafumi C. , Sekiya Hiroaki , Liu Chia-Chen , Martens Yuka A. , Rosenberg Cassandra L. , Kuchenbecker Lindsey A. , DeTure Michael , Reichard R. Ross , Nguyen Aivi T. , Constantopoulos Eleni , Larsen Rachel A. , Kounaves Emmaline K. , Murray Melissa E. , Dickson Dennis W. , Petersen Ronald C. , Bu Guojun , Kanekiyo Takahisa 
Published: February 2024

AbstractAlzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (pTau), is increasingly recognized as a complex disease with multiple pathologies. AD sometimes pathologically overlaps with age-related tauopathies such as four repeat (4R)-tau predominant argyrophilic grain disease (AGD). While AGD is often detected with AD pathology, the contribution of APOE4 to AGD risk is not clear despite its robust effects on AD pathogenesis. Specifically, how APOE genotype influences Aβ and tau pathology in co-occurring AGD and AD has not been fully understood. Using postmortem brain samples (N = 353) from a neuropathologically defined cohort comprising of cases with AD and/or AGD pathology built to best represent different APOE genotypes, we measured the amounts of major AD-related molecules, including Aβ40, Aβ42, apolipoprotein E (apoE), total tau (tTau), and pTau181, in the temporal cortex. The presence of tau lesions characteristic of AD (AD-tau) was correlated with cognitive decline based on Mini-Mental State Examination (MMSE) scores, while the presence of AGD tau lesions (AGD-tau) was not. Interestingly, while APOE4 increased the risk of AD-tau pathology, it did not increase the risk of AGD-tau pathology. Although APOE4 was significantly associated with higher levels of insoluble Aβ40, Aβ42, apoE, and pTau181, the APOE4 effect was no longer detected in the presence of AGD-tau. We also found that co-occurrence of AGD with AD was associated with lower insoluble Aβ42 and pTau181 levels. Overall, our findings suggest that different patterns of Aβ, tau, and apoE accumulation mediate the development of AD-tau and AGD-tau pathology, which is affected by APOE genotype.
Artificial intelligence and quantum cryptography
Authors: Radanliev Petar 
Published: February 2024

AbstractThe technological advancements made in recent times, particularly in artificial intelligence (AI) and quantum computing, have brought about significant changes in technology. These advancements have profoundly impacted quantum cryptography, a field where AI methodologies hold tremendous potential to enhance the efficiency and robustness of cryptographic systems. However, the emergence of quantum computers has created a new challenge for existing security algorithms, commonly called the ‘quantum threat’. Despite these challenges, there are promising avenues for integrating neural network-based AI in cryptography, which has significant implications for future digital security paradigms. This summary highlights the key themes in the intersection of AI and quantum cryptography, including the potential benefits of AI-driven cryptography, the challenges that need to be addressed, and the prospects of this interdisciplinary research area.
Seascape connectivity: ontogenetic migration for Haemulon flavolineatum
Authors: Rodriguez-Torres Diana Carolina , Acosta Alberto 
Published: February 2024

AbstractIn the seascape, species migrate between ecosystems to complete their life cycles, and such ontogenetic migrations create functional connections between ecosystems. Nevertheless, the scarcity of information on patch distribution, species life history and ecology limits its application in Marine Protected Areas (MPA) management. We use a potential connectivity network approach to analyze how Haemulon flavolineatum might move through a complex and diverse seascape by simulating part of its life cycle migrations among three ecosystems (reef, mangrove, and seagrass) in the MPA of Bahía Portete-Kaurrele (BPK), Colombia. We used available ecosystem cover maps to conduct habitat fragmentation analyses and evaluate structural connectivity in BPK using eight indices that describe ecosystem patches and how they are related. With published information on the H. flavolineatum home range and its ontogenetic migration distances, we estimated the potential functional connectivity (CONNECT and migration distances) between ecosystems by building bipartite graphs. The benthic habitat configuration of the BPK could allow Haemulon flavolineatum to complete at least two stages of its life cycle (stage 5 mangroves to reefs being more likely than stage 4 seagrass to mangroves). Ontogenetic migrations is possible since, patches of different ecosystems were highly intermixed (76%) rather than grouped (58%); reefs showed higher values of structural indices (patch area, largest patch, shape complexity, functional links) than mangrove (shortest distance to the nearest neighbor) and seagrass (representativeness); and juveniles migrate from mangroves to reef patches along the bay, but they could be isolated by distance when moving from particular seagrass to mangrove patches. Our methodological approach, which integrates ecological information (evidence-based ranges of species migration distances between habitat patches) and the seascape (spatial configuration of habitat patches and fragmentation) is novel for a marine fish species with ontogenetic migration to search for the likelihood of completing its life cycle stages. We discuss the need for ecological information on French grunts and the need to validate future models and scenarios.
Translation and psychometric assessment of the mastectomy module of the BREAST-Q questionnaire for use in Nigeria
Authors: Olasehinde Olalekan , Lynch Kathleen A. , Goldman Debra A. , Agodirin Olaide , Okereke Chukwuma , Wuraola Funmilola O. , Owoade Israel Adeyemi , Akinmaye Promise Rebecca , Ajibade Olusola , Barber Karin , Ogunwale Joshua , Alatise Olusegun , Kingham T. Peter , Pusic Andrea , Romanoff Anya 
Published: February 2024

Abstract
Background
The majority of non-metastatic breast cancer patients in sub-Saharan Africa are recommended to have mastectomy. The impact of mastectomy on a predominantly young African patient population requires evaluation. The BREAST-Q is a validated patient-reported outcome measure of quality-of-life following breast surgery that has been translated into 30 languages-none in Africa. This study aimed to translate and assess the psychometric properties of the mastectomy module of the BREAST-Q for use in Nigeria.

Methods
The BREAST-Q mastectomy module was translated from English to Yoruba and its psychometric properties assessed using best practice guidelines. Translation was performed in 4 steps: forward translation (x2), back translation, back translation review, and cognitive interviews with post-mastectomy patients. The translated BREAST-Q instrument was administered to post-mastectomy patients (n = 21) alongside the EORTC-QLQ BR23 to evaluate construct validity. Test-retest reliability was evaluated using intraclass correlation coefficients (ICC); surveys were re-administered 4 weeks apart.

Results
The translation process identified English phrases not amenable to direct translation, including “emotionally healthy” and descriptions of pain (“nagging,” “throbbing,” “sharp”). Translations were amended to reflect local context and question intent. During cognitive interviews, patients provided suggestions to simplify complex phrases, e.g. “discomfort in your breast area.”. Internal consistency within scales was over 0.70 for psychosocial wellbeing (α = 0.84–0.87), sexual wellbeing (α = 0.98–0.99), physical wellbeing in chest (α = 0.84–0.86), and satisfaction with care (α = 0.89–0.93). ICC for test-retest reliability was moderate (0.46–0.63).

Conclusions
The Yoruba version of the BREAST-Q mastectomy module presents a unique opportunity to adequately capture the experiences of Nigerian women post mastectomy. This instrument is being used in a pilot study of Nigerian patients to identify targets for intervention to improve the patient experience and compliance with breast cancer surgery.
Cerebral MRI in a prospective cohort study on depression and atherosclerosis: the BiDirect sample, processing pipelines, and analysis tools
Authors: Wulms Niklas , Kugel Harald , Cnyrim Christian , Tenberge Anja , Schwindt Wolfram , Dannlowski Udo , Berger Klaus , Sundermann Benedikt , Minnerup Heike 
Published: February 2024

Abstract
Background
The use of cerebral magnetic resonance imaging (MRI) in observational studies has increased exponentially in recent years, making it critical to provide details about the study sample, image processing, and extracted imaging markers to validate and replicate study results. This article reviews the cerebral MRI dataset from the now-completed BiDirect cohort study, as an update and extension of the feasibility report published after the first two examination time points.

Methods
We report the sample and flow of participants spanning four study sessions and twelve years. In addition, we provide details on the acquisition protocol; the processing pipelines, including standardization and quality control methods; and the analytical tools used and markers available.

Results
All data were collected from 2010 to 2021 at a single site in Münster, Germany, starting with a population of 2,257 participants at baseline in 3 different cohorts: a population-based cohort (n = 911 at baseline, 672 with MRI data), patients diagnosed with depression (n = 999, 736 with MRI data), and patients with manifest cardiovascular disease (n = 347, 52 with MRI data). During the study period, a total of 4,315 MRI sessions were performed, and over 535 participants underwent MRI at all 4 time points.

Conclusions
Images were converted to Brain Imaging Data Structure (a standard for organizing and describing neuroimaging data) and analyzed using common tools, such as CAT12, FSL, Freesurfer, and BIANCA to extract imaging biomarkers. The BiDirect study comprises a thoroughly phenotyped study population with structural and functional MRI data.

Relevance statement
The BiDirect Study includes a population-based sample and two patient-based samples whose MRI data can help answer numerous neuropsychiatric and cardiovascular research questions.

Key points
• The BiDirect study included characterized patient- and population-based cohorts with MRI data.
• Data were standardized to Brain Imaging Data Structure and processed with commonly available software.
• MRI data and markers are available upon request.

Graphical Abstract
Comparative analysis of SIMILAR to RCD ONE (SRO) family from tetraploid cotton species and their diploid progenitors depict their significance in cotton growth and development
Authors: Shaban Muhammad , Tabassum Riaz , Rana Iqrar Ahmad , Atif Rana Muhammad , Azmat Muhammad Abubakkar , Iqbal Zubair , Majeed Sajid , Azhar Muhammad Tehseen 
Published: February 2024

Abstract
Background
SRO (Similar to RCD1) genes family is largely recognized for their importance in the growth, development, and in responding to environmental stresses. However, genome-wide identification and functional characterization of SRO genes from cotton species have not been reported so far.

Results
A total of 36 SRO genes were identified from four cotton species. Phylogenetic analysis divided these genes into three groups with distinct structure. Syntenic and chromosomal distribution analysis indicated uneven distribution of GaSRO, GrSRO, GhSRO, and GbSRO genes on A2, D5 genomes, Gh-At, Gh-Dt, Gb-At, and Gb-Dt subgenomes, respectively. Gene duplication analysis revealed the presence of six duplicated gene pairs among GhSRO genes. In promoter analysis, several elements responsive to the growth, development and hormones were found in GhSRO genes, implying gene induction during cotton growth and development. Several miRNAs responsive to plant growth and abiotic stress were predicted to target 12 GhSRO genes. Organ-specific expression profiling demonstrated the roles of GhSRO genes in one or more tissues. In addition, specific expression pattern of some GhSRO genes during ovule development depicted their involvement in these developmental processes.

Conclusion
The data presented in this report laid a foundation for understanding the classification and functions of SRO genes in cotton.
Brentuximab vedotin resistance in classic Hodgkin's lymphoma and its therapeutic strategies: a review
Authors: Bera Dayeeta , Roy Dattatreya 
Published: February 2024

Abstract
Background
Bone marrow cancer has been at the forefront of cancer research. The propensity of cancers to extravasate to the bone makes it a very relevant topic in the topology of this heterogeneous disease. Our narrative review article addresses Brentuximab vedotin (BV) resistance in classic Hodgkin’s lymphoma patients and discusses the current trends in the therapeutic process. The data have been collected from the works of well-established researchers, and the scientific evidence was abundantly supplemented with clinical and pre-clinical trial data. Although the findings cited are the latest, this review might not be very accurate for every population as the data from which this was derived have a population bias in several instances. The analysis has mostly been qualitative and interpretive, and quantitative evidence has only been used to explain the clinical trial results. We have divided our paper into the mode of action of BV, its probable and proven causes of resistance, and the therapeutic strategies employed to reverse them to ensure a systemic flow of information throughout the text.

Main body
Brentuximab vedotin is an antibody–drug conjugate with antineoplastic activity, used to target a novel immunophenotype tumor necrosis factor CD30. This factor is specific to the tumor-causing Reed-Sternberg cells in the inflammatory infiltrate. Though the drug had shown promise initially, the cancer was quick to develop resistance against the drug. We have analyzed and represented abundant statistical evidence to back this claim. The paper further discusses the role of the CD30 receptor, MDR1 gene, valine–citrulline linker, and tumor microenvironment in drug resistance. Lastly, we have discussed the possible therapeutics that can be used to overcome this resistance, discussing the well-established and trial-stage approaches taken in the endeavor.

Conclusion
The treatment is much better after the pursuit of reversing the drug resistance phenomenon. However, no therapeutic approach has been entirely successful in restricting the neoplastic property of cancer cells once and for all. This paper describes why that is so and how the heterogeneity of the disease complicates troubleshooting. We have tried to approach such problems through this specific example.
ONC201 (Dordaviprone) in Recurrent H3 K27M–Mutant Diffuse Midline Glioma
Authors: Arrillaga-Romany Isabel , Gardner Sharon L. , Odia Yazmin , Aguilera Dolly , Allen Joshua E. , Batchelor Tracy , Butowski Nicholas , Chen Clark , Cloughesy Timothy , Cluster Andrew , de Groot John , Dixit Karan S. , Graber Jerome J. , Haggiagi Aya M. , Harrison Rebecca A. , Kheradpour Albert , Kilburn Lindsay B. , Kurz Sylvia C. , Lu Guangrong , MacDonald Tobey J. , Mehta Minesh , Melemed Allen S. , Nghiemphu Phioanh Leia , Ramage Samuel C. , Shonka Nicole , Sumrall Ashley , Tarapore Rohinton S. , Taylor Lynne , Umemura Yoshie , Wen Patrick Y. 
Published: February 2024

PURPOSE Histone 3 (H3) K27M–mutant diffuse midline glioma (DMG) has a dismal prognosis with no established effective therapy beyond radiation. This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in recurrent H3 K27M–mutant DMG. METHODS Fifty patients (pediatric, n = 4; adult, n = 46) with recurrent H3 K27M–mutant DMG who received oral ONC201 monotherapy in four clinical trials or one expanded access protocol were included. Eligible patients had measurable disease by Response Assessment in Neuro-Oncology (RANO) high-grade glioma (HGG) criteria and performance score (PS) ≥60 and were ≥90 days from radiation; pontine and spinal tumors were ineligible. The primary end point was overall response rate (ORR) by RANO-HGG criteria. Secondary end points included duration of response (DOR), time to response (TTR), corticosteroid response, PS response, and ORR by RANO low-grade glioma (LGG) criteria. Radiographic end points were assessed by dual-reader, blinded independent central review. RESULTS The ORR (RANO-HGG) was 20.0% (95% CI, 10.0 to 33.7). The median TTR was 8.3 months (range, 1.9-15.9); the median DOR was 11.2 months (95% CI, 3.8 to not reached). The ORR by combined RANO-HGG/LGG criteria was 30.0% (95% CI, 17.9 to 44.6). A ≥50% corticosteroid dose reduction occurred in 7 of 15 evaluable patients (46.7% [95% CI, 21.3 to 73.4]); PS improvement occurred in 6 of 34 evaluable patients (20.6% [95% CI, 8.7 to 37.9]). Grade 3 treatment-related treatment-emergent adverse events (TR-TEAEs) occurred in 20.0% of patients; the most common was fatigue (n = 5; 10%); no grade 4 TR-TEAEs, deaths, or discontinuations occurred. CONCLUSION ONC201 monotherapy was well tolerated and exhibited durable and clinically meaningful efficacy in recurrent H3 K27M–mutant DMG.
Tasks and role of the tourist complex in the system of social and economic development of the national economy
Authors: Barna Marta , Iablon Volodymyr 
Published: February 2024

The relevance of the methodological problem of improving the theoretical and methodological foundations of tourism as a complex of the national economy lies in the fact that this sector of the economy has every reason to become one of the priority and promising branches of the national economy of Ukraine. The grounds for this conclusion are good natural and climatic conditions and the presence of a wide variety of tourist resources, namely natural-recreational, historical-cultural and socio-economic. Ukraine is characterized not only by a large number of destinations, but also by itself, in general, it can be considered as a single large complex tourist destination.The purpose of the study is to improve the conceptual provisions and substantive characteristics of the tourist complex as an object of state policy.During the study, the methods of logical generalization (to determine the conceptual provisions of the tourism sector of the economy), grouping (to identify the environment of the tourism sector), analysis and synthesis (to ensure a systematic approach in the formation of the state policy for regulating the development of the tourism sector) were used.The applied value of the research results lies in the identification of the decomposition of the tourist complex of the national economy.
The scientific novelty of the research results lies in the further development of the methodological and applied principles of tourism as (1) an industry, (2) a type of economic activity, (3) a sector, (4) a complex of the national economy.
Unifying Procedure-Dependent Preference Reversals: Theory and Experiments
Authors: Guo Liang 
Published: February 2024

Revealed preferences between alternatives can be systematically reversed across a variety of elicitation procedures (e.g., choice, valuation, matching, joint/separate evaluation). These puzzling findings have been usually invoked to challenge the procedure invariance principle. Yet procedure-dependent preferences can be endogenous. This paper presents a unifying theory of contextual deliberation to account for seemingly disparate phenomena of preference reversals. When attribute importance is ex ante imperfectly known, people can engage in costly information retrieval/acquisition activities (i.e., deliberation) prior to making decisions. Elicitation procedures can influence revealed preferences through affecting the incentive for deliberation. Therefore, contextual deliberation can endogenously yield procedure-dependent preference reversals, offer a common microfoundation for extant psychological accounts (e.g., the prominence hypothesis, the evaluability hypothesis), and coherently organize apparently unrelated/inconsistent findings in the literature. We also run five experiments and document new findings that are inconsistent with extant hypotheses but can be reconciled by contextual deliberation. This paper was accepted by Dmitri Kuksov, marketing. Funding: This work was supported by the Hong Kong Research Grant Council (RGC) General Research Fund [Grant 16500614]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2021.02640 .
Reliable Frequency Regulation Through Vehicle-to-Grid: Encoding Legislation with Robust Constraints
Authors: Lauinger Dirk , Vuille François , Kuhn Daniel 
Published: February 2024

Problem definition: Vehicle-to-grid increases the low utilization rate of privately owned electric vehicles by making their batteries available to electricity grids. We formulate a robust optimization problem that maximizes a vehicle owner’s expected profit from selling primary frequency regulation to the grid and guarantees that market commitments are met at all times for all frequency deviation trajectories in a functional uncertainty set that encodes applicable legislation. Faithfully modeling the energy conversion losses during battery charging and discharging renders this optimization problem nonconvex. Methodology/results: By exploiting a total unimodularity property of the uncertainty set and an exact linear decision rule reformulation, we prove that this nonconvex robust optimization problem with functional uncertainties is equivalent to a tractable linear program. Through extensive numerical experiments using real-world data, we quantify the economic value of vehicle-to-grid and elucidate the financial incentives of vehicle owners, aggregators, equipment manufacturers, and regulators. Managerial implications: We find that the prevailing penalties for nondelivery of promised regulation power are too low to incentivize vehicle owners to honor the delivery guarantees given to grid operators. Funding: This work was supported by the Institut Vedecom. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0154 .
The importance of transformational leadership
Authors: Thomas Vinice 
Published: February 2024

Transformational leadership is a leadership style that is often compared to and contrasted with transactional leadership. Where the latter tends to be more task-orientated and has a part to play in specific managerial contexts, transformational leadership focuses on the power of relationships to inspire others to achieve a shared vision, with longer lasting effects. The benefits of transformational leadership place it as one of the most applied leadership styles in health care, with positive impacts seen on the workforce, organisational productivity, and patient outcomes. Developing transformational leaders across all levels of an organisation is strongly recommended, due to the benefits highlighted in the literature. Any organisation wishing to grow its transformational leaders must first identify intrinsic and extrinsic factors within the organisation and its culture that could act as obstacles. Authors are in agreement that the skills, knowledge and behaviours of a transformational leader can be learnt, therefore investment in such development programmes is important. This article explores the importance of transformational leadership and how staff can develop the competencies required to grow as a transformational leader in health and social care.