bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrence of Drug-Induced Lupus Secondary to Vedolizumab Use in a Patient With Crohn's Disease
Authors: Rodriguez Vanessa I. , Mathavan Akshay , Mathavan Akash , Rodriguez Diana N. , Alvarez Catalina Sanchez , Pham Angela 
Published: January 2024

ABSTRACT
Drug-induced lupus is an autoimmune phenomenon characterized by the development of systemic lupus erythematosus–like clinical features after drug exposure. The entity is a clinical diagnosis. Evaluation consists of recognizing systemic lupus erythematosus–like features, identifying an appropriate causative agent, observing elevations of characteristic autoantibodies, and obtaining positive response with drug discontinuation. Vedolizumab is an anti-α4β7 antibody used in the treatment of ulcerative colitis and Crohn's disease. We report a novel case of drug-induced lupus recurrence secondary to vedolizumab use in a patient with Crohn's disease, emphasizing diagnostic evaluation, and provide a brief review of the published literature.
Comparison of the diagnostic value of fine needle aspiration and ultrasound in thyroid pathology
Authors: Glushkov P. S. , Azimov R. Kh. , Aleshenko N. L. , Maruchak E. A. , Sych Y. P. , Minkova G. N. , Shemyatovsky K. A. , Gorsky V. A. 
Published: January 2024

Fine needle aspiration (FNA) biopsy has been a powerful tool in the preoperative diagnosis of thyroid nodules for more than 60 years. The Bethesda scale standardizes the results of cytology and is a tool for interaction between the laboratory and the clinician. At the same time, there is a stratification of ultrasound signs of thyroid lesions according to the TI-RADS scale. In this regard, it became necessary to determine the diagnostic value of ultrasound signs of thyroid lesions, stratified by TI-RADS, in comparison with the results of a biopsy, classified by the Bethesda scale.AIM: a comparative assessment of the results of FNA and ultrasound in determining indications for the surgical treatment of thyroid nodules.MATERIALS AND METHODS: for 2018–2021 in the surgical department of the SCC №2 of the Petrovsky National Research Centre of Surgery, 859 FNA were performed. For comparative analysis, 141 patients who underwent surgery for thyroid nodules were selected. All patients at the preoperative stage underwent FNA with stratification of the results according to the Bethesda scale and ultrasound of the thyroid gland with stratification according to the EU-TI-RADS scale.RESULTS: FNA showed high diagnostic accuracy and sensitivity, preoperative thyroid ultrasound had high specificity, but low sensitivity. The high diagnostic value of FNA was confirmed by statistical analysis of the obtained data (OR 31.29 95% CI 2.20–4.69, RR 13.28 95% CI 1.46–3.71). When analyzing preoperative ultrasound, it was not possible to obtain reliable statistical results (OR 2.99 95% CI 0.34-1.85, RR 1.97 95% CI 0.23-1.12).CONCLUSION: Ultrasound of the thyroid gland cannot replace FNA in thyroid nodules. Biopsy remains the main diagnostic method for nodular goiter. The main objective of TI-RADS-stratified ultrasound is to select patients for subsequent FNA.
Quality of life in patients with hyperparathyroidism before and after surgical treatment
Authors: Ilyicheva E. A. , Bersenev G. A. , Roy T. A. 
Published: January 2024

BACKGROUND: Hyperparathyroidism (HPT) is a syndrome characterized by excessive synthesis of parathyroid hormone (PTH), an imbalance of phosphorus-calcium metabolism, and damage to target organs. Radical treatment of any clinical variant of HPT is surgical. In this regard, the assessment of the quality of life (QoL) of patients before and after surgery is an indicator that reflects the impact of the disease on the patient’s health and the effectiveness of the treatment.AIM: To study QoL of patients with various clinical variants of HPT before and after surgical treatment.MATERIALS AND METHODS: The single-center prospective study included patients operated on for primary (PHPT), secondary (SHPT) and tertiary HPT in 2019–2021. A comparison was made of preand postoperative QoL indicators with a sample comparable in sex and age from residents of the Irkutsk region.RESULTS: The study included 100 patients, of which 13 had multiple lesions of the parathyroid glands (PTG) and 51 with solitary lesions in PHPT, 34 with SHPT and 2 with SHPT. Indicators QoL of patients with HPT before surgery is statistically significantly lower than in the region. The greatest decrease in QoL was found in the group of patients with multiple PTG lesions in PHPT. Improvement in QoL was achieved in 90% of the studied patients. Despite the identified complications, there was an improvement in QoL after surgery in case of achieving remission of the disease. Persistence of the disease is an outcome that does not allow for a statistically significant improvement in QoL after surgery for any type of HPT. Deterioration of QoL according to some indicators was found in 10% of patients. In patients with solitary PTG lesions in PHPT, deterioration in QoL is associated with postoperative hypocalcemia against the background of the «hungry bones» syndrome, and in patients with SHPT with a decrease in parathyroid hormone below population indicators.CONCLUSION: The study demonstrates QoL of patients with various clinical variants of hyperparathyroidism before and after surgical treatment. The dynamics of QoL indicators depending on the nosology, volume, duration, outcome and complications of operations is shown.
Evolutionary game analysis of government, businesses, and consumers in high-standard farmland low-carbon construction
Authors: Dai Yuting , Liu Jinbao , Du Yichun 
Published: January 2024

Abstract
Soil is an important carbon reservoir, and high-standard farmland construction projects have significant potential to promote low-carbon development. In order to study the management and implementation of low-carbon production in high-standard farmland construction projects, the tripartite evolution game model of government, business, and consumer is constructed based on the tripartite bounded rationality. Then, the behavior strategy of tripartite stakeholders is analyzed with the method of system dynamics. Finally, the evolution process of tripartite interaction behavior is simulated using the MATLAB tool. The results show that: (1) The subsidy and punishment mechanism of the government must be aligned. In addition, the net income of government regulation is higher than the sum of the government’s environmental governance fees and fines of non-regulation; (2) The government, business, and consumers all choose their own behavioral strategies based on their own interests. (3) When the government’s environmental governance fee reaches a particular value, the system will appear imbalanced. In light of this, it is suggested that the government should increase support for business and use media publicity, consumer subsidies, and other measures to promote the consumption of low-carbon products. The business should constantly reduce the cost of carbon emission reduction through technological innovation.
First albino white-eared opossums in the Caatinga, Northeastern Brazil: records of albinism in Didelphis albiventris (Lund, 1840)
Authors: Freire-Filho Robério , Lopes Alexandre Martins Costa , Câmara Tainara , Damasceno Calebe , Cordeiro José Luís Passos , Vilela Júlio Fernando 
Published: January 2024

Abstract
Unusual colorations are rare in Didelphis, but records are important to understand genetic aspects of the species. Albino individuals have a total absence of pigmentation throughout the body (skin and hair) and have eyes without traces of pigmentation, but with a red or pink color. We draw attention to the first two confirmed records of albinism in white-eared opossum (Didelphis albiventris) and their karyotype. This is the first record of albinism in D. albiventris in Northeastern Brazil. This calls attention to develop future research on the genetic diversity and the risk of inbreeding and consanguinity in populations of this region.
Risk assessment of hitch pins connecting tractor and trailer to enhance the safety of humans using strain life fatigue approach
Authors: Chopra S. , Kumar P. , Kumar M. 
Published: January 2024

Abstract
The hitch pin is a critical component between tractor and trailer. The failure of hitch pins is quite frequent and a serious issue which remains unaddressed to a great extent due to limited information on this topic. This paper presents a novel insight into substandard pins manufactured in the informal sector due to non-conformance to any established standard and opens up a new area for further research on this subject. In the present context, risk factors along with reasons of cracks of in-service hitch pins were assessed to enhance the safety of humans. The pin showed signs of a crack, corrosion, scratches, and dents. Notches and scratches acted as stress raisers. Cracks can be seen initiating from the tip of notches. The pin was made of non-standard mild steel and was not heat treated. The study further demonstrates the methods to improve the fatigue life of the pin using numerical simulation. The hardness method was used to collect the cyclic fatigue properties of the commercially available mild steel for different heat-treated samples using the strain life fatigue approach. The casehardened mild steel pin of a case depth of 1.3 mm with a hardness of 30 HRC had considerably increased fatigue properties. Recommendations have been provided to protect humans from these accidents.
A New Multiphase Apparatus for Testing Soil Permeated with Three Immiscible Fluids
Authors: Yu Jia-ren , Zhou Chao 
Published: January 2024

Abstract
Oil-contaminated unsaturated soil is a complex multiphase material. In this study, a new triaxial apparatus was developed to independently control/measure its air, oil, and water pressures. Therefore, the suctions associated with air–water, air–oil, and oil–water interfaces can be determined. The apparatus utilizes the hanging column and axis-translation techniques to control suctions in 0∼5 kPa and 5∼600 kPa. It is suitable for investigating water/oil retention, isotropic compression, and triaxial shear behavior of oil-contaminated soil. Using this new apparatus, five tests were conducted to analyze the saturation–pressure (S–P) relationship of sand and sandy silt at various oil and water contents and to evaluate the validity of the axis-translation technique for soil permeated with three nonimmersible fluids. Results showed that the artificial increase of air pressure in the axis-translation technique does not obviously alter the air–water and air–oil suctions at constant oil and water contents. A popular suction–saturation model, which was proposed based on test results of clean sands, showed a good prediction of the air–oil suction. However, the oil–water suction results of sandy silt do not align with the model prediction, suggesting that the model may need to be revised for soils with some silt and clay particles.
Measurements of the Limit of Detection for Electrochemical Gas Sensors
Authors: Saffell John R. , Martin Nicholas A. 
Published: January 2024

Abstract
Electrochemical amperometric gas cells are becoming the sensor of choice when measuring polluting gases using low-cost air quality networks. A number of technical issues remain to be resolved to deliver fit-for-purpose monitoring systems: humidity corrections are needed but not well understood, interfering gases such as ozone can have variable cross-sensitivity and calibration intervals, and procedures are still being investigated. Another unanswered question is the limit of detection (LOD) for electrochemical gas sensors. Estimates range from hundreds of equivalent parts per billion (ppbv) to single-digit ppbv concentrations. We discuss the LOD for nitrogen dioxide (NO2), an important gas when monitoring air quality. Multiple NO2 sensor systems were tested in an environmental chamber to determine, among other parameters, the LOD for NO2 electrochemical gas sensors. Low-noise electronics and battery powering further reduced electronic noise, allowing the intrinsic LOD of the electrochemical cell to be determined. Noise, quantified as the standard deviation in zero air in a very stable temperature and relative humidity–controlled chamber was &lt;500 pA, which translated into 1.6 ppbv, so the LOD, 3 × standard deviation, was 4.8 ppb. Interestingly, the LOD calculated with 300 ppbv NO2 test gas was the same (±0.1 ppbv). Further tests with a higher resolution analog-to-digital converter resulted in the same LOD, further leading to the conclusion that for the Alphasense NO2-A43F NO2 sensor, the limiting value for LOD is 4.8 ppbv.
Delineating geological structure utilizing integration of remote sensing and gravity data: a study from Halmahera, North Molucca, Indonesia
Authors: Aprina Patria Ufaira , Santoso Djoko , Alawiyah Susanti , Prasetyo Nugroho , Ibrahim Khalil 
Published: January 2024

Halmahera Island is the result of the interaction between the Indo-Australian Plate, the Molucca Sea Plate, and the Philippine Plate, which gave rise to many active geological structures that are vulnerable to seismic activity around the island. The complexity of this geological structure makes Halmahera Island very interesting to study. This study aims to identify geological structures by integrating remote sensing and gravity satellite data. Surface lineament analysis using the remote sensing method was carried out based on Sentinel-1A imagery data. The gravity method uses GGMPlus satellite data to clarify the continuity of geological structures that cannot be clearly mapped on the surface. Lineament analysis on gravity data uses techniques such as fast sigmoid edge detection (FSED) and Euler deconvolution. The results of lineament interpretation based on integrating remote sensing and gravity satellite data show that the NE-SW structure controls the northern and northeastern arms of Halmahera.
In contrast, the southern arm is dominated by the NW-SE structure. The Euler depth estimation shows that the Halmahera area contributes to having geological structures at various depths. Deep structures reach 4 km, while shallow structures are found at depths of up to 2 km. Earthquake hypocenter data strengthen the interpretation of this geological structure. This comprehensive study yields an excellent correlation between gravity and remote sensing techniques in describing the general structural framework of the area. The new finding is an NE-SW trending geological structure on the northern Halmahera arm, which may be caused by two different tectonics first, the subduction of the Molucca Sea Plate with the Halmahera Plate in the west. Second, the strike-slip movement is trending NE-SW, which cuts the northern and northeastern arms due to the rotational movement of the thrust fault with the Philippine Plate to the west.
Možnosti pridelave hrane na zemljiščih s težkimi kovinami
Authors: Vovk Ana 
Published: January 2024

Težke kovine škodljivo vplivajo na prst, ker ovirajo procese humifikacije v prsti. V zemlji prisotne težke kovine se vgradijo v rastline in preidejo v prehranjevalno verigo ter povzročajo huda obolenja. Potrebno je izbrati ustrezen pridelovalni sistem, ki pa je odvisen od geografske lastnosti parcele kot so lastnosti prsti, matična kamnina oz. sediment, naklon, ekspozicija, smer vetra, odtok površinske vode in sevanja. V prispevku je prikazan primer rabe poplavljenih zemljišč s toksičnim muljem po poplavah z uporabo vertikalnih sistemov. Gre za pridelovalne pristope, kjer z nalaganjem biomas dvignemo pridelovalno površino in jo ločimo od osnovne zemljine. Ti pristopi omogočajo takojšnjo pridelavo hrane na varen način, saj koreninski sistemi rastlin niso v stiku z matično zemljino.
ANALISIS KESALAHAN MAHASISWA PGSD DALAM MEMECAHKAN MASALAH GEOMETRI DITINJAU DARI PRIOR KNOWLEDGE
Authors: Subanji Subanji , Kusumawati Elli , Wardhani Indah Setyo 
Published: January 2024

Penelitian ini mengkaji kesalahan mahasiswa dalam memecahkan masalah geometri melalui penelusuran prior knowledge. Penelitian ini merupakan penelitian studi kasus tipe instrumental melibatkan 185 mahasiswa PGSD Universitas Trunojoyo Madura. Subjek menyelesaikan instrumen pelacak prior knowledge dan dilanjutkan pemecahan masalah. Hasil penelitian menunjukkan bahwa 71 (38,37%) gagal menyelesaikan masalah segitiga dan 124 (67,02%) subjek gagal menyelesaikan masalah jajar genjang. Kesalahan menyelesaikan masalah tersebut dikarenakan kesalahan memahami prior knowledge. Kesalahan pemecahan masalah dapat dikelompokkan menjadi empat bentuk yaitu: (1) kesalahan representasi; (2) kesalahan menggambar garis tinggi, (3) kesalahan dalam menggunakan teorema phytagoras, dan (4) kesalahan memahami konteks berbeda. Sebaran kesalahan prior knowledge: 87,75% kesalahan memahami aksioma, definisi dan representasi dalam geometri sebesar; dan 26,49% kesalahan representasi gambar. Kata kunci: Prior Knowladge, Pemecahan Masalah, Geometri Abstract: This study examines students' mistakes in solving geometric problems through searching prior knowledge. This research is an instrumental type case study involving 185 PGSD students at Trunojoyo University, Madura. The subject completed the prior knowledge tracking instrument and continued problem solving. The results showed that 71 (38.37%) failed to solve the triangle problem and 124 (67.02%) subjects failed to solve the parallelogram problem. Errors in solving these problems are due to errors in understanding prior knowledge. Problem solving errors can be grouped into four forms, namely: (1) misrepresentation; (2) mistakes in drawing heights, (3) mistakes in using the Pythagorean theorem, and (4) mistakes in understanding different contexts. Prior knowledge error distribution: 87.75% error in understanding the axioms, definitions and representations in geometry by; and 26.49% image representation error. Keywords: Prior Knowladge, Problem Solving, Geometry.
Rate and Risk Factors for Contralateral Slippage in Adolescents Treated for Slipped Capital Femoral Epiphysis
Authors: Momtaz David , Mirghaderi Peyman , Gonuguntla Rishi , Singh Aaron , Mittal Mehul , Burbano Andres , Hosseinzadeh Pooya 
Published: January 2024

Background:
After a unilateral slipped capital femoral epiphysis (SCFE), the contralateral hip is at risk for a subsequent SCFE. However, further information with regard to risk factors involved in the development of contralateral SCFE must be investigated. The purpose of this study was to report the rate and risk factors for subsequent contralateral SCFE in adolescents treated for unilateral SCFE by exploring a mix of known and potential risk factors.

Methods:
A case-control study utilizing aggregated multi-institutional electronic medical record data between January 2003 and March 2023 was conducted. Patients <18 years of age diagnosed with SCFE who underwent surgical management were included. Variables associated with contralateral SCFE were identified using multivariable logistic regression models that adjusted for patient characteristics and time of the surgical procedure, providing adjusted odds ratios (ORs). The false discovery rate was accounted for via the Benjamini-Hochberg method.

Results:
In this study, 15.3% of patients developed contralateral SCFE at a mean (and standard error) of 296.53 ± 17.23 days and a median of 190 days following the initial SCFE. Increased thyrotropin (OR, 1.43 [95% confidence interval (CI), 1.04 to 1.97]; p = 0.022), diabetes mellitus (OR, 1.67 [95% CI, 1.22 to 2.49]; p = 0.005), severe obesity (OR, 1.81 [95% CI, 1.56 to 2.57]; p < 0.001), history of human growth hormone use (OR, 1.85 [95% CI, 1.10 to 3.38]; p = 0.032), low vitamin D (OR, 5.75 [95% CI, 2.23 to 13.83]; p < 0.001), younger age in boys (under 12 years of age: OR, 1.85 [95% CI, 1.37 to 2.43]; p < 0.001) and in girls (under 11 years of age: OR, 1.47 [95% CI, 1.05 to 2.02]; p = 0.026), and tobacco exposure (OR, 2.43 [95% CI, 1.49 to 3.87]; p < 0.001) were significantly associated with increased odds of developing contralateral SCFE.

Conclusions:
In the largest study on this topic, we identified the rate, odds, and risk factors associated with development of contralateral SCFE. We found younger age, hypothyroidism, severe obesity, low vitamin D, diabetes mellitus, and a history of human growth hormone use to be independent risk factors. Our findings can aid clinical decision-making in at-risk patients.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Tsunami Height Estimation by Gaussian Process Regression Using Maximum Pressure Change and Arrival Time at Seafloor Sensors off the Kii Peninsula, Japan
Authors: Iwabuchi Yutaro , Baba Toshitaka , Hori Takane , Okada Masato , Igarashi Yasuhiko 
Published: January 2024

Abstract

The Dense Ocean-floor Network for Earthquakes and Tsunamis (DONET) was recently installed to monitor tsunamis in the Nankai trough.
In this study, an advanced tsunami prediction model using Gaussian process regression that is suitable for seafloor pressure observations is proposed.
The maximum tsunami height and tsunami arrival time observed at seafloor pressure sensors are used as explanatory variables.
Because tsunami data observed by ocean observatories are insufficient for constructing Gaussian regression relationships, numerical tsunami simulations are used for learning and validation.
After tsunami detection by DONET, the accuracy of tsunami height prediction along the coast is improved by considering the tsunami arrival time at seafloor pressure sensors. The proposed model enables rapid and effective estimation of coastal tsunami heights.
Recent status of Phase I clinical trials for brain tumors: a regulatory science study of exploratory efficacy endpoints
Authors: Watanabe Shinya , Nonaka Takahiro , Maeda Makoto , Yamada Masanobu , Sugii Narushi , Hashimoto Koichi , Takano Shingo , Koyanagi Tomoyoshi , Arakawa Yoshihiro , Ishikawa Eiichi 
Published: January 2024

Abstract
Background
Appropriate exploratory efficacy data from Phase I trials are vital for subsequent phases. Owing to the uniqueness of brain tumors (BTs), use of different strategies to evaluate efficacy is warranted. We studied exploratory efficacy evaluation in Phase I trials involving BTs.
Methods
Using Clarivate’s CortellisTM, 42 Phase I trials of BT interventions conducted from 2020 to 2022 were analyzed for efficacy endpoints, which were set as primary endpoints (PEs) or secondary endpoints (SEs). Additionally, these metrics were compared in two subgroups: trials including only BTs (Group-A) and those including BTs among mixed solid tumors (Group-B).
Results
Selected studies included a median of 1.5 PEs (range, 1–6) and 5 SEs (range, 0–19). Efficacy endpoints were included as PEs and SEs in 2 (5%) and 31 (78%) trials, respectively. Among the latter 31 trials that included 94 efficacy endpoints, 24, 22, 20, 9, and 8 reflected overall response rate (ORR), progression-free survival (PFS), overall survival (OS), duration of response (DOR), and disease control rate (DCR), respectively. ORR for BT was determined using various methods; however, the Response Evaluation Criteria in Solid Tumors was used less frequently in Group-A than in Group-B (p = 0.0039).
Conclusions
Recent Phase I trials included efficacy endpoints as SEs, with ORR, PFS, or OS included in ~50% trials and DOR or DCR in ~25%. No established criteria exist for imaging evaluation of BTs. Phase I trials involving mixed solid tumor cohorts revealed challenges in designing methods to assess the exploratory efficacy of BTs.