bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Experience and First Impression in The Liminal Spaces (Case Studies: Corridors and Stairs in Campus Environment)
Authors: Naja Muhammad Farhat , Kuswanto Iqbal Raihan , Purnama Alan , Fathurraziqin Habib , Wardhani Mustika Kusumaning 
Published: January 2024

Humans and their feelings are a 'unique' study in architectural design, such as how humans behave in some spatial settings. Spatial settings are usually defined as an environment that contains specific activities. However, what about transitional spaces or corridors that only serve as intermediaries for 'some walking experience'? The discussion related to liminal space becomes interesting, mainly when studied from the perspective of architectural psychology. This study aims to investigate human experiences and perceptions of liminal spaces, focusing on two locations: the corridors and the stairs at the campus. The research method used is mixed methods, with random samplings collected through an online survey to explore feelings, visuals, and hearing responses to liminal spaces. The study results show that respondents who have experienced being in a liminal space tend to have contra-perceptions of the Alienation theory by Marx, which can be attributed to the habits of the respondents in dealing with that space and their objective nature. Meanwhile, respondents with perceptions that align with Alienation theory tend to be influenced by their feelings and visual imagination. Moreover, respondents whose perceptions aligned with the theory expressed their discomfort and anxiety caused by unconducive room conditions. This research contributes to understanding human experiences and perceptions in liminal spaces with limitations including a small number of respondents and intangible indicators, making it difficult to explain perceptions in nominal terms. Thus, this research can broaden the understanding of architectural psychology and spatial perception.
Troponin testing in routine primary care: observations from a dynamic cohort study in the Amsterdam metropolitan area
Authors: Harskamp Ralf E. , Melessen Indra M. , Manten Amy , De Clercq Lukas , den Elzen Wendy P.J. , Himmelreich Jelle C.L. 
Published: January 2024

Abstract

Objectives
Troponin testing is indicated in the diagnostic work-up of acute coronary syndrome (ACS) and incorporated in risk stratification pathways. This study aims to gain insights on the use, outcomes, and diagnostic accuracy of troponin testing in routine primary care; a setting that is understudied.

Methods
Routine data were used from the academic primary care network in the Amsterdam metropolitan area (968,433 patient records). The study population included adult patients who underwent high-sensitivity troponin I or T (hs-TnI/T) testing between 2011 and 2021. The primary outcome was the reported diagnosis and the secondary outcome was the diagnostic accuracy measured by death or ACS at 30 days.

Results
3,184 patients underwent hs-troponin testing, either with hsTNT (n=2,333) or hsTNI (n=851). Median patients’ age was 55 (44–65) years, and 62.3 % were female. Predominant symptoms were chest pain and dyspnea (56.7 %). Additional diagnostic laboratory tests were commonly performed (CRP: 47.7 %, natriuretic peptides: 25.6 %, d-dimer: 21.5 %). Most common diagnoses were musculoskeletal symptoms (21.6 %) and coronary heart disease (7.1 %; 1.1 % ACS). Troponin testing showed sensitivity and specificity of 77.8 % (60.9–89.9) and 94.3 % (93.5–95.1), respectively. Negative and positive predictive values were 99.7 (99.5–99.9) and 13.5 (11.1–16.4), and positive and negative likelihood ratios were 13.7 (10.9–17.1) and 0.24 (0.13–0.43).

Conclusions
GPs occasionally use troponin testing in very low-risk patients, often as part of a multi-marker rule-out strategy. The diagnostic characteristics of troponin tests, while promising, warrant prospective validation and implementation to facilitate appropriate use.
Multiple solitons, periodic solutions and other exact solutions of a generalized extended (2 + 1)-dimensional Kadomstev--Petviashvili equation
Authors: Humbu Isaac , Muatjetjeja Ben , Motsumi Teko Ganakgomo , Adem Abdullahi Rashid 
Published: January 2024

Abstract
This paper aims to study a generalized extended

(

2
+
1

)

{(2+1)}

-dimensional Kadomstev–Petviashvili (KP) equation. The KP equation models several physical phenomena such as shallow water waves with weakly nonlinear restoring forces. We will use a variety of wave ansatz methods so as to extract bright, singular, shock waves also referred to as dark or topological or kink soliton solutions. In addition to soliton solutions, we will also derive periodic wave solutions and other analytical solutions based on the invariance surface condition. Moreover, we will establish the multiplier method to derive low-order conservation laws. In order to have a better understanding of the results, graphical structures of the derived solutions will be discussed in detail based on some selected appropriate parametric values in 2-dimensions, 3-dimensions and contour plots. The findings can well mimic complex waves and their underlying properties in fluids.
On the mean field games system with lateral Cauchy data via Carleman estimates
Authors: Klibanov Michael V. , Li Jingzhi , Liu Hongyu 
Published: January 2024

Abstract
The second-order mean field games system (MFGS) in a bounded domain with the
lateral Cauchy data are considered. This means that both Dirichlet and
Neumann boundary data for the solution of the MFGS are given. Two Hölder
stability estimates for two slightly different cases are derived. These
estimates indicate how stable the solution of the MFGS is with respect to
the possible noise in the lateral Cauchy data. Our stability estimates imply
uniqueness. The key mathematical apparatus is the apparatus of two new Carleman estimates.
A new onset drug induced diabetes mellitus presenting with diabetic ketoacidosis in a child undergoing treatment for B cell acute lymphoblastic leukemia. A case report and review of literature
Authors: Sharma Preeti , Vyas Varuna , Didel Siyaram , Singh Kuldeep 
Published: January 2024

Abstract

Objectives
Hyperglycemia is a known side effect of anticancer chemotherapeutic drugs. This entity known as drug-induced diabetes mellitus usually does not present with the development of diabetic ketoacidosis (DKA). We hereby report a case of drug induced diabetes mellitus in a child with acute leukemia presenting with DKA.

Case presentation
We report a case of a teenage boy diagnosed with B cell acute lymphoblastic leukemia and was started on induction phase chemotherapy as per the Indian Collaborative Childhood Leukemia group (ICICLe) acute lymphoblastic leukemia-14 protocol. On day 12 of the induction phase, he developed hyperglycemia and presented to us with severe diabetic ketoacidosis (DKA). Serum anti glutamic acid decarboxylase 65 antibody levels were negative with low serum C peptide levels. Initially, the possibility of drug-induced acute pancreatitis was kept which was ruled out. Keeping the possibility of drug-induced hyperglycemia, the child was started on subcutaneous regular insulin which was titrated as per sugar records. Continuation of remaining chemotherapy was done by PEGylated L-asparaginase with titration of insulin as per home-based sugar records. Insulin requirement increased from 0.3 unit/kg/day to a maximum of 1 unit/kg/day during consolidation phase 1 with PEGylated L-asparaginase suggesting drug-induced hyperglycemia but subsequently insulin requirement decreased and insulin was stopped.

Conclusions
Drug induced diabetes mellitus can present as DKA during induction phase of acute lymphoblastic leukemia (ALL) chemotherapy. A high index of suspicion and close monitoring are required. The insulin requirements in these patients can be very fluctuant and may become nil during the course of treatment.
Diversity of amyloid beta peptide actions
Authors: Mardanyan Sona , Sharoyan Svetlana , Antonyan Alvard 
Published: January 2024

Abstract
Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight. The main efforts in pharmacology are aimed at reducing Aβs concentration to prevent their accumulation, aggregation, formation of senile plaques, neuronal death, and neurodegeneration. However, a number of publications have demonstrated certain beneficial physiological effects of Aβs. Simultaneously, it is indicated that the effects of Aβs turn into pathological due to the development of certain diseases in the body. The accumulation of C- and N-terminal truncated Aβs under diverse conditions is supposed to play a role in AD development. The significance of transformation of glutamate residue at positions 3 or 11 of Aβs catalyzed by glutaminyl cyclase making them more degradation resistant, hydrophobic, and prone to aggregation, as well as the participation of dipeptidyl peptidase IV in these transformations are discussed. The experimental data presented confirm the maintenance of physiological, nonaggregated state of Aβs by plant preparations. In conclusion, this review suggests that in the fight against AD, instead of removing Aβs, preference should be given to the treatment of common diseases. Glutaminyl cyclase and dipeptidyl peptidase IV can be considered as targets in AD treatment. Flavonoids and plant preparations that possess antiamyloidogenic propensity are proposed as beneficial neuroprotective, anticancer, and antidiabetic food additives.
Erfolgreiche Spitzensportförderung?
Authors: Borggrefe Carmen , Cachay Klaus , Werner Konstantin 
Published: January 2024

Zusammenfassung
Anschließend an die aktuelle Debatte über Ziele und Formen der Spitzensportförderung in Deutschland geht der vorliegende Beitrag auf der Basis systemtheoretischer Überlegungen der Frage nach, wie sich der Spitzensport erfolgreich steuern lässt. Dabei wird erstens dargelegt, dass Steuerung – systemtheoretisch betrachtet – nur als dezentrale Kontextsteuerung möglich erscheint. Zweitens wird die aktuelle Zielstellung der Förderung von „Medaillenpotenzial“ reflektiert, um daran anschließend einen Vorschlag für die Neuausrichtung dieser Zielstellung zu präsentieren, die auf die Lösung von Inklusionsproblemen der Athleten- und Trainerrolle über den Aufbau von Systemvertrauen gerichtet ist. Drittens wird die Konstellation der Steuerungsakteure in Form relevanter Organisationen nachgezeichnet, bevor darauf aufbauend viertens die Angemessenheit von Steuerungsformen im Kontext relevanter Interorganisationsbeziehungen reflektiert wird. Der Beitrag schließt mit konkreten Handlungsempfehlungen für die zukünftige Steuerung des Spitzensports in Deutschland.
Formulations in Chinese criminal courtroom interaction
Authors: He Xiaodan 
Published: January 2024

Abstract
This study investigates the interactional functions and properties of formulation sequences in Chinese criminal courtroom using the methods of Conversation Analysis. The data corpus for this study are audio recordings of five criminal trials heard in China. I show that (i) in response to opaque answers in the prior turn, the examiner tendentiously formulates the prior description to highlight the implication or inferences, for his or her pragmatic purpose; (ii) the examiner clarifies, redevelops the gist, makes something explicit that was previously implicit in the prior turn; or (iii) shifts the focus of the prior turn to make explicit a presumptive and damaging inference, in hostile examination, or to highlight favorable information in cooperative questioning. A key linguistic property of formulations is that they are preceded by turn initial discourse markers, which serves to indicate the examiner’s neutrality and credibility. Moreover, closed polar questions or tag questions in formulations are used by examiners to invite aligning and positive responses.
Advanced testing and characterization of low-temperature cracking in bitumen and mastic
Authors: Shabani Amir , Jelagin Denis , Partl Manfred N. 
Published: January 2024

AbstractLow-temperature cracking is one of the most common failures in asphalt pavements, especially in cold regions. Accordingly, considerable amount of research has been performed in order to understand the low-temperature cracking mechanisms and to propose test methods for characterizing and determining cracking performance of bitumen and asphalt mixtures under freezing conditions. The existing test methods, however, require expensive equipment and skilled technicians; they are thus not well suited for routine tests. As a contribution to mitigate this situation, this study intends to investigate experimentally and characterize numerically the low-temperature cracking behavior of bitumen and mastic materials using a refined thermal cracking test method. The proposed method, the annular restrained cold temperature induced cracking (ARCTIC) test, allows to determine the low-temperature cracking properties of the mastic and bitumen with a relatively simple setup. In this paper, finite element (FE) modeling is used for evaluating the effect of test parameters on the temperature, stress and strain gradients induced in the specimen during the test. The ARCTIC test is employed to measure cracking temperatures of two bitumen and two mastic materials. The measurements repeatability is examined and the effect of bitumen type on the thermal cracking potential of bitumen and mastic is evaluated. FE modeling is employed to examine the effect of thermomechanical parameters on thermal cracking performance of the materials and to back-calculate fracture stress and strain from measurements. The results highlight the potential of the proposed test and analysis method for evaluation of low-temperature cracking in bitumen and asphalt mastic.
Sensitivity evaluation of methods for screening JAK2 exon 12 mutations based on heteroduplex and HRM analysis
Authors: Subbotina T. N. , Shalyova A. A. , Shevchenko A. I. , Pozdysheva E. A. , Voytsekhovskaya Ya. A. , Mironov K. O. 
Published: January 2024

Background. According to WHO guidelines, one of the criteria for diagnosis of polycythemia vera is the presence of somatic mutations in exon 12 of the JAK2 gene, but to date there is no universally accepted simple method to analyze these mutations. We have previously proposed two methods for screening such mutations based on heteroduplex and HRM (High Resolution Melt) assays, which are relatively cheap and fast compared to sequencing.Aim. To analyze the sensitivity of these screening methods.Materials and methods. The study used cloned DNA samples from 6 patients with various mutations in exon 12 of the JAK2 gene that we had previously identified, as well as a clone of the corresponding wild-type DNA segment. Dilution of the cloned mutant samples with wild-type clones was performed to obtain samples with different levels of allele burden: 100, 50, 25, 12.5, 6.25, 3.13, 1.56 and 0.78 %. Heteroduplex analysis followed by PAGE (polyacrylamide gel) and HRM analysis was then performed with the diluted samples.Results. The sensitivity threshold of the heteroduplex analysis was found to be between 3.13–6.25 % allele burdens depending on the specific mutation, the sensitivity threshold of the HRM assay was 6.25–12.5 % similarly.Conclusion. Our proposed methods of heteroduplex analysis followed by PAGE and HRM-analysis for the detection of polycythemia vera-specific mutations in exon 12 of the JAK2 gene allow increasing the efficiency of using different types of sequencing and can be used as simpler and less expensive methods of preliminary screening of these mutations.
Concepciones de interculturalidad y práctica en aula: estudio con maestros de comunidades shipibas en el Perú
Authors: Cépeda García Nora , Castro Burgos Dina , Lamas Basurto Pilar 
Published: January 2024

Este artículo presenta resultados de una investigación cualitativa y comparativa. Tuvo como objetivo general identificar las concepciones de interculturalidad de los docentes de dos escuelas interculturales bilingües shipibo-castellano en Lima y dos en Ucayali, y describir cómo están presentes en su práctica educativa de aula y planificación curricular. La metodología incluyó entrevistas semiestructuradas, observaciones y análisis de unidades de aprendizaje. Los resultados pasaron por un proceso de reducción de datos y triangulación. En la concepción de interculturalidad de los maestros se encontraron temáticas prevalentes: afirmación de la cultura propia, encuentro con otras lenguas y culturas e intercambio entre culturas. Se encontró relación entre sus concepciones y sus prácticas en aula. Mientras que la planificación curricular muestra diferencias en la incorporación de contenidos con perspectiva intercultural entre las escuelas de Lima y Ucayali.
Optimizing Well Placement and Recovery in Mature Gas Condensate Reservoirs Through the Utilization of Pseudo Pressure Approach
Authors: Iqbal Muneez , Mehmood Saad , Azeem Abdul , Hussain Sadam , Zakir Mufaddal Murtaza , Younas Muhammad Avais , Tanveer Atif 
Published: January 2024

Abstract
This paper overcomes the challenge of reliable prediction by capturing condensate banking effects in the numerical simulation models, and to identify remaining sweet spots for infill drilling. In the rich gas condensate, the heavier components in the gas phase drop out below saturation pressure, it causes: (1) Decline in gas production, (2) Loss of valuable condensate components, both of which manifest in the form of expanding condensate bank incorporated in this study.
The case study is of a rich gas condensate field located in the Middle Indus Basin of Pakistan. A detailed compositional simulation model including matched PVT has been developed using commercial simulator to study the effects of condensate banking and its impact in the history matching and forecast. Local grid refinements (LGR) and Generalized pseudo pressure (GPP) approaches have been utilizing and compared in this case study for the improvement of history match along with the reliable predictions. An applied workflow has been developed to locate sweet spots in order to target future development well opportunities in the field.
A comparative analysis has been performed in this case study using LGR and GPP approach to study the impact of condensate drop-out on wells productivity. As sector model was developed for the comparison between the techniques and later on the results applied on the full field simulation. GPP approach was much faster with better history matched results as compared to LGR. The forecast generated using GPP technique when later compared with actual field performance was much realistic. As a result, the model was then utilized to identify infill development opportunities in the field. The developed workflows resulted in evaluating two infill wells with incremental recovery of 10-12% of the field.
The work is computationally intensive with time & resource constraints challenges. Availability of advanced workflow generation rendered the overall execution in an efficient and timely manner.
Coupled Baseline Estimation and Trend Analysis Approach to Differentiate Natural and Mine-Related Stresses on Groundwater Levels
Authors: Jackson Tracie , Zhan Guosheng 
Published: January 2024

Abstract

Permitting and regulatory obligations require mine operators to periodically report the spatial extent of mine-induced water-level changes, and to provide water-level monitoring data for review, along with explanations of all hydrologic stresses causing water-level trends. This study couples a baseline-estimation method with a curve-fitting trend-analysis approach to determine all natural, mining, and non-mining aquifer stresses affecting water levels in wells. The approach was applied to the Twin Creeks Mine monitoring network in north-central Nevada, USA. Stresses identified in wells were used to delineate the approximate extent of pumping effects and indicated that drawdowns have not coalesced between mining and non-mining pumping areas. Trend-analysis results indicated that ten study-area well hydrographs have natural trends, and statistical methods identified three of these wells as having statistically significant downward trends. Thus, caution should be used when interpreting the meaning of statistically significant downward trends, because the downward trend may be climate driven rather than pumping related. The curve-matching approach requires the development of a baseline water-level trend to understand expected natural fluctuations. The baseline trend assumes a dynamic-equilibrium natural condition, where long-term net changes in groundwater levels are zero. The baseline trend and trend analysis require a recharge proxy for the study area. This study developed recharge proxies using winter precipitation data, peak reservoir-storage volumes, and metered mine-water discharge to a surface-water channel. The curve-matching approach also can be used to identify and remove erroneous data, reconcile water-level and pumping datasets, or build hydrologic conceptualizations.
Synthesis of biogenic nano-silica hydrogel from foxtail millet ashes husk via greener approach
Authors: Govindaraj c , Sudarsan S. , Parthiban E. , Bharathi A. , Selvakumar C. , Andrews B. 
Published: January 2024

Abstract
Hydrogels are hydrophilic groups of three-dimensional polymeric biomaterials that can absorb huge quantities of biological fluids and water molecules. The hydrogels played an important role in eco-friendly parameters like pH, electric field, temperature, ionic concentration, and solvent composition. The preparation of pH-sensitive hydrogels of foxtail millet ashes husks with the presence of hydrochloric acid to the formation of biogenic nano-silica hydrogels toward a low-cost, simple, solventless greener approach. The chemical structure and morphology of hydrogels was identified using FT-IR spectra techniques, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The swelling equilibrium studies of nano-silica hydrogels at different pH values from 1.2 to 15.2 have been examined. Swelling studies results indicate the percentage of swelling is comparation higher at neutral pH than acidic and alkaline pH. The swelling properties of eco-friendly hydrogels increase chain length from biogenic nano-silica hydrogels. The hydrogel’s adaptableness with pH-sensitive properties may have better probable in greener approach like dye removal, metal ion removal, agrochemical release, and biomedical field.