bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Paradiguna (Samskara) W.S.R to “Samaskarohi Gunantaradhanam Uchyate” and ITS Applied Aspect in the Management of Mukhadushika with an Indiginous Drug
Authors: Biswas Susmita , Sahoo Manoj Kumar 
Published: February 2024

Introduction: Acharya Charaka has clearly said that if one does not understand these Paradi Guna in proper way then he cannot perform Chikitsa in desire manner. Paradi Gunas are the one in which a physician needs to be expertise. Paradigunas are necessary in the field of pharmaceutical science, as well as by the physicians to treat the patients and researchers conducting research and creating new formulation. Samskara Guna is one of the important factors in the hands of Ayurvedic physician for improving other third padas of Bhesaja (i.e., Bahuta, Yogyatwa, and Sampat). Thus in this study, an attempt was made to know the comparative effect of Manjistha Lepa and Samskrita Manjistha with Madhu Lepa in the management of Mukhadushika. Aims and Objectives: The aim of the study was to study about the comparative clinical efficacy of Manjistha Lepa and triturated with Madhu Lepa in the management of Mukhadushika. Materials and Methods: This is a single-blind comparative clinical study with a pre-test and post-test design. The patients were randomly categorized into two groups. Forty patients of Group A (20) and Group B (20) patients were registered from outpatient department of Government Ayurvedic College and Hospital, Balangir, and Saradeswari Government Hospital, Balangir, presented with subjective parameters and objective parameters. After diagnosis, they were under trial with Ayurvedic formulations of Manjistha Lepa for local application and Manjistha triturated Madhu Lepa given 05 g in morning time daily, after drying face wash with normal water for 15 days, respectively. The subjective and objective parameters were assessed in 7-day interval to interpret the result by statistical evaluation. Observation and Results: It had been observed that the result of trial drug Group B patients was significant (<0.05) to reduce both subjective and objective parameters after 15 days of treatment as compared to Group A patients. In Group A, NO patients had marked improvement, while 15% of patients had moderate improvement, 65% mildly improved and 20% had shown unsatisfactory result. In Group B, no patients had marked improvement, 50% moderate, 40% mildly improved, and 10% of patients showed unsatisfactory results. In both groups, the result was statistically significant, but more improvement was noticed in Group B. Conclusion: On comparison between two groups, Manjistha triturated with Madhu Lepa in Group B had shown more effect than Manjistha Lepa in Group A. No adverse effects were noticed during clinical trial in both groups.
Analysis of Vatavyadhi Samprapti – A Practical Perspective
Authors: Mohanta Sarita , Das Arun Kumar 
Published: February 2024

Introduction: Ayurveda is one of the oldest medical systems comprising numerous medical concepts and hypotheses. Vatavyadhi is an important chapter described in all Samhitas. Vatavyadhi patients are increasing in day-to-day practice, so a clear understanding is necessary on its pathogenesis. Vatavyadhi occurs due to vitiation of Vatadosha. Vayu gets vitiated due to numerous factors staring from diet to various habits, used medicines, environmental changes, etc. Inside body Vayu gets vitiated and produces diseases either due to Dhatukshaya or Margavarodha. Materials and Methods: To analyze the Samprati (Pathogenesis) of Vatavyadhi from various Samhitas, contexts and the views of researchers are taken into consideration as method of the review. Discussion and Conclusion: Vatavyadhi is a group of special diseases which is produced due to aggravate Vata. Due to different etiological factors, Vata Prakopa occurs through Dhatukshaya and Margavarodha process which later produce Vatavyadhi. These pathological processes may be regarded as Vishista Samprati (Pathogenesis) of Vatavyadhi. During pathogenesis annoyed Vata may assemble with Pitta and Kapha, leading to modification of clinical features.
Surya Namaskar, Benefits in the Context of Physiological Perspective
Authors: Patni Nameet Kumar , Devi Durgawati , Jain Sonam 
Published: February 2024

Introduction: With the recent rise in awareness in increased understanding of the importance of physical activity in promoting overall health, greater emphasis has been placed on improving physical fitness to enhance quality of life. Asian Indians have been practicing Surya Namaskar, a part of Hatha Yoga, for hundreds of years. It is frequently employed in place of a typical workout regimen. It entails a series of asanas that are performed 12 times per cycle. Although Surya Namaskar was neither considered an asana nor a part of classical Yoga, it is now regarded as a component of current yogic practices. Before starting daily tasks, performing Surya Namaskar energizes the practitioner and gives them a fully charged day. The knowledge of energy cost and physiological responses of practicing Surya Namaskar is important and forms the basis for the recommendation of regular practice as part of any training. Based on available research, we emphasize the significance of Surya Namaskar in this review by stressing its impacts on the physiological components of the body. Methods: Different Ayurveda classics, modern classics, research papers, and journals were referred to fulfill this part. Results: With the help of research references, the evaluation outlines the practice’s physical advantages in terms of improving joint mobility, extending muscle power, and promoting vitality.
Arogyavardhini Vati – Critical Analysis of a Miracle Drug
Authors: Sahoo Preetimayee , Mahanta Nihar Ranjan , Mishra Sanjay Kumar 
Published: February 2024

Introduction: Arogyavardhini Vati is a herbomineral preparation which has miraculous effects on many diseases. It has the ability of balancing Tridosha and is beneficial in many liver disorders, dyslipidemia, metabolic syndrome, skin diseases, etc. Many clinical research and animal studies have been done to establish its actions in various diseases and its safety during use. Material and Methods: Here, in this article, an attempt is made to collect all the literary data about Arogyavardhini Vati from our treaties and all the research articles available. These data are compiled and analyzed and the results obtained are presented. Results: The Rasapanchaka analysis shows that Arogyavardhini Vati is Tikta Rasa Pradhana (27.59%) followed by Kashaya (24.14%) and Katu (20.69%) rasa, predominant in Laghu (29.03%) and Ruksha Guna (29.03%), Ushna Virya predominant (54.55%), and the Vipaka was katu (54.55%). Discussion: Research evidence shows that Arogyavardhini Vati is effective on various liver diseases such as hepatitis, non-alcoholic and alcoholic fatty liver, Jalodara or ascites due to liver disorder, and autoimmune liver disease. Animal experiments also proved its hepatoprotective activities. It has anti-hyperlipidemic action, helps in metabolic syndrome, and is beneficial in many skin diseases. It reduces the pus discharge in karna srava or chronic suppurative otitis media. Studies show that pharmaceutical and analytical parameters for Arogyavardhini Vati are validated by HPTLC method. Toxicity studies show no accumulation or toxic effect of mercury and copper on vital organs. Conclusion: Arogyavardhini vati is safe and miraculously effective in many diseases.
Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke
Authors: Li Jinshi , Yu Cong , Liang Shu , Ren Dabin , Zheng Ping 
Published: February 2024

IntroductionAccumulating studies have shown that copper has a detrimental effect in cells, and the cuproptosis-related gene signatures have been constructed as clinical tools to predict prognosis in tumors. However, the heterogeneity of cuproptosis has not been fully investigated in ischemic stroke.Material and methodsHere, we combined the bulk RNA-seq and single cell-RNA-seq data for stroke to investigate the role of cuproptosis in stroke.ResultsWe identified the cuproptosis-related differentially expressed genes (CuDEGs) in ischemic stroke. Then, we tried to find the hub genes with the machine learning method and WGCNA. We highlighted four genes identified by these methods and proposed a potential diagnostic model in ischemic stroke.ConclusionsOur findings revealed cuproptosis-related hub genes, which could provide useful biomarkers in ischemic stroke.
Penguatan Sosialisasi Anti-Narkoba di Lingkungan Sekolah Dasar Sebagai Upaya Membangun Kesadaran dan Perlindungan Anak-Anak
Authors: Sebayang Gabriela Anjelika Br , Br Ginting Sari Jusnita , Simamora Monang Tua 
Published: February 2024

Kegiatan pengabdian masyarakat bagi dosen merupakan upaya untuk melaksanakan salah satu tugas tridharma perguruan tinggi. Pengabdian kepada masyarakat yang dilakukan dalam kegiatan ini yaitu Sosialisasi Pencegahan Narkoba Menuju Kecerdasan Bangsa di Sekolah Dasar Negeri (SDN) 040443 yang teletak di Kabanjahe. Kegiatan ini bertujuan untuk melaksanakan kegiatan tridharma perguruan tinggi Dosen demi memberikan sumbangsih ilmu pengetahuan dan sosialisasi ke masyarakat. Pengabdian yang dilakukan oleh beberapa dosen di Universitas Audi Indonesia ini memberikan bekal pengetahuan masyarakat di SDN 040443 Kabanjahe agar memiliki pemahaman edukasi yang diberikan tentang pencegahan narkoba untuk membangun kesadaran dan perlindungan anak terutama kepada Siswa/I SDN 040443. Target luaran yang diharapkan dari kegiatan ini adalah : membekali pengetahuan kepada masyarakat SDN 040443 Kabanjahe tentang pencegahan narkoba membangun kesadaran dan perlindungan anak-anak.
Participación, construcción de ciudadanía juvenil y desarrollo territorial: algunas reflexiones
Authors: Jiménez Morales Rommy Ivette 
Published: February 2024

Este artículo analiza la relación entre desarrollo territorial, participación ciudadana, y juventud. La reflexión que se presenta sigue ese orden en los cuales se busca exponer algunos elementos teóricos, e insistir en la importancia de transformación de paradigmas de lo que se conoce por ciudadanía y juventud. Hay que decir que más que un cambio de denominación hace referencia a un posicionamiento que presta atención a la importancia tanto de la participación como de la construcción de ciudadanía. En este trabajo se presentan una serie de aportes teóricos como marco de referencia para el análisis de la participación ciudadana de las personas jóvenes. Los análisis de la participación juvenil deben superar la propensión a entenderlo solo desde lo cuantificable, lo descriptivo, lo normativo, o bien desde la aparentemente apatía de las personas de jóvenes.
Los aspectos que se examinan tienen como propósito aportar de algún modo a la discusión sobre la necesidad de debatir sobre la ciudadanía de la juventud, lo cual se expresa en el protagonismo, en los aportes que pueden hacer y que hacen al desarrollo social y político en el país. El rol de las personas jóvenes es diverso, debido a que, como se hace hincapié en este trabajo, no son unilaterales, y tampoco se puede hablar de juventud, sino de juventudes, puesto que se precisa una visión más amplia e integral, que tome en cuenta la diversidad. Tal como se plantea en el artículo no es lo mismo ser una persona joven con ilimitados recursos económicos, que empobrecido, ser mujer que ser hombre, habitar o bien provenir de un espacio rural que urbano.
Existen algunos elementos que pueden ser relevantes para el estímulo de la participación y construcción de ciudadana juvenil entre los cuales se pueden mencionar los espacios y mecanismos de participación y ello puede ser un primer paso. Empero su sola existencia no es garantía para la participación se requieren transformaciones relacionadas con las formas en las cuales se toman decisiones y su carácter vinculante, con el derecho a tener voz y voto, con el acceso a la información pública.
ECA Estudios Centroamericanos, Vol. 78, No. 773, 2023: 75-97.
Models of Heuristic Brain Activity and Artificial Intelligence
Authors: Еськов В. М. , Филатов М. А. , Воронюк Т. В. , Самойленко И. С. 
Published: February 2024

познавательная деятельность человека связана с созданием (изучением) двух типов информации: объективно новой и субъективно новой. В проблеме создания искусственного интеллекта первый тип деятельности (создание объективно новой информации) занимает особую (главную) роль. В этом случае такие искусственные системы действительно могут заменить человека. В работе обсуждаются два новых режима работы искусственных нейросетей, которые имеют место в работе мозга человека. Оказалось, что введение этих двух режимов в работу уже существующих нейросетей позволяет моделировать эвристическую работу мозга. Такие интеллектуальные системы решают задачи системного синтеза и находят параметры порядка. До настоящего времени такие задачи не формализованы в математике и у них нет общего решения
in human cognitive processes, we encounter the generation and handling of two types of information: the objectively new and the subjectively new. The pursuit of creating artificial intelligence places a primary emphasis on the first type, the creation of objectively new information. In this context, such artificial systems can potentially serve as effective replacements for human cognitive abilities. The study delves into two novel operational modes of artificial neural networks, inspired by the functioning of the human brain. It was discovered that integrating these modes into existing neural networks enables us to simulate the heuristic functioning of the brain. As a result, these intelligent systems demonstrate proficiency in tackling challenges related to system synthesis and the identification of order parameters. Presently, these problems lack formalization in mathematics and do not possess a universally accepted solution
PERANCANGAN BUKU DIGITAL TARI JARANAN SEBAGAI UPAYA MELESTARIKAN BUDAYA LOKAL KEDIRI
Authors: Amalia Riska Rahma , Hidayat Much Duchan 
Published: February 2024

Indonesia adalah negara dengan banyak kebudayaan, salah satunya adalah tarian tradisional. Banyak cara untuk melestarikan tarian tradisional dengan menarik minat generasi muda, salah satunya adalah kisah tari tradisional tersebut dijadikan sebuah buku cerita. Salah satunya adalah dengan mengangkat kisah awal tari tradisional jaranan Kediri. Di zaman yang semakin maju, penggunaan gawai kian meningkat pesat, dengan memanfaatkan gawai maka pelestarian cerita rakyat lebih mudah diciptakan sebuah komik dalam bentuk digital agar mudah membaca, mengakses dan menyebarkannya lebih muda.Untuk menciptakan buku digital, dilakukan metode kualitatif untuk mendapatkan sumber data. Metode kualitatif mudah menemukan hasil data yang sesuai dengan keinginan peneliti, karena dengan menjabarkannya secara rinci. Untuk mendapatkan data yang sesuai, dilakukan pengumpulan data dengan cara wawancara penari jaranan asal kediri, observasi di sekitar sanggar, dan dokumentasi. Setelah mendapatkan data maka dilakukan analisis data, maka digunakannya analisis model interaktif untuk mendapatkan hasil memuaskan atau jenuh.dalam pembuatan buku digital mengenai awal kisah jaranan Kediri.Kemudahan dalam mengakses internet, memudahkan peneliti dalam menyebarkan buku digital Awal Kisah Jaranan Kediri ini. Setelah mengumpulkan data dan dilakukan analisis, peneliti menciptakan sebuah buku digital. Dalam penyebarannya, media pokok yang digunakan adalah dalam bentuk digital yang dapat disebarkan dan diakses dengan mudah, media pendukung buku digital Awal Kisah Jaranan Kediri ini diantaranya adalah dalam bentuk kaos, x-banner, totebag, mug dan stiker. Dengan diciptakannya komik digital ini, peneliti atau perancang untuk kedepannya agar tergugah untuk menciptakan karya-karya lain dengan mengusung tema kebudayaan Indonesia.
Associations of bovine beta-casein and kappa-casein genotypes with genomic merit in Holstein Friesian cattle
Authors: Ardicli Sena , Aldevir Özgür , Aksu Emrah , Kucuk Kerem , Gümen Ahmet 
Published: February 2024

Abstract. The relationship between the index values used to evaluate the genomic value and essential markers such as casein genes provides important information at the herd level. Therefore, this study aimed to determine the association between casein gene genotypes and the indices of genetic merit in Holstein Friesian cattle. A total of 805 cows were genotyped using the Affymetrix® Axiom® array system. We used data composed of the total performance index (TPI) and net merit (NM) values as well as the predicted transmitting abilities (PTAs) indices, including milk, fat, fat percentage, protein, protein percentage, combined fat and protein (CFP), productive life (PL), somatic cell score (SCS), daughter pregnancy rate (DPR), livability (LV), udder composite (UDC), and feet–legs composite (FLC) of each animal. The statistical analysis consisted of a one-way analysis of variance (ANOVA) test followed by Tukey's test. The A2A2 and the AB genotypes were predominant in the CSN2 and CSN3 genes, respectively. The A2A2 animals were found to have higher TPI and NM values. Moreover, they exhibited higher PTA values for proteins, CFP, and PL. On the other hand, the A1A1 genotype was significantly associated with the highest UDC. Concerning the CSN3 haplotypes, the BB animals had higher protein percentage and PL than alternative haplotypes. The AA and AB haplotypes were found to be significantly associated with the highest SCS and DPR values, respectively. In addition, the BE haplotype had the highest NM. Selection procedures focusing on casein genes in dairy cattle are becoming increasingly common worldwide, especially for A2 milk. However, herd-based dynamics are also fundamental to providing a desired genetic merit for the animals. This study may be valuable for further analyses regarding selection decisions using the breeding values of candidate animals in commercial dairy herds.
Fetal Femoral Artery Doppler Evaluation in Late-Onset Fetal Growth Restriction: A Case-Control Study
Authors: FARİSOĞULLARI Nihat , TANACAN Atakan , SAKCAK Bedri , DENİZLİ Ramazan , AĞAOĞLU Zahid , KARA Özgür , SAHİN Dilek 
Published: February 2024

Objective: To compare the femoral artery and other ultrasonographic Doppler measurements between fetuses with late-onset fetal growth restriction and uncomplicated fetuses.
Material and method: This prospective cohort study was conducted with 168 patients, including 83 pregnancies presenting with late-onset fetal growth restriction and 85 uncomplicated control pregnancies at similar gestational weeks. The study group was further divided into two according to the neonatal intensive care unit requirements. Demographic characteristics, obstetric characteristics, femoral artery and other ultrasonographic Doppler measurements, and pregnancy outcomes were compared between the groups.
Results: Uterine artery pulsatility index, umbilical artery systolic/diastolic ratio, and peak systolic velocity of the middle cerebral artery were similar between the study and control groups. However, while the middle cerebral artery pulsatility index was significantly lower in the study group, the femoral artery pulsatility index value was significantly higher (p
Conceptual bases for realization of human-machine interaction
Authors: Симанков В.С. , Онищенко С.В. 
Published: February 2024

В работе представлен обзор исследований в области организации че-ловеко-машинных систем, определена возможная схема построения системного интел-лекта как инструмента для реализации процессов принятия решений в сложных информационных системах с множеством различных интеллектуальных агентов, подразумевающая комплексное взаимодействие различных видов интеллектов в зависимости от имеющегося уровня неопределенности в системе на конкретном этапе ее функционирования.
The paper presents an overview of research in the field of organization of hu-man-machine systems, defines a possible scheme for building system intelligence as an instru-ment for implementing decision-making processes in complex information systems with many different intellectual agents, implying a complex interaction of various types of intelligence de-pending on the existing level of non-certainty in the system at a specific stage of its functioning.
Linguocultural and cognitive characteristics of colour concepts in French and Russian languages
Authors: Хажокова Э.А. 
Published: February 2024

Статья посвящена проблеме изучения цветовых концептов в разносистемных языках. Рассмотрены основные хроматичные и ахроматичные цвета французского и русского языков, на базе которых формируются вторичные (переносные) значения. Отмечается, что на актуализацию значения цвета влияет совокупность лингвистических и экстралингвистических факторов. Изучены способы концептуализации цветовых обозначений, являющихся неотъемлемой частью языковой картины мира. Установлено, что во французском и русском языках спектр цветообозначений совпадает, но при этом наблюдаются существенные различия в восприятии цветового пространства у носителей этих языков.
The article is devoted to the problem of studying colour concepts in languages of different systems. Specifically, it focuses on the examination of the principal chromatic and achromatic colours within the French and Russian languages, as they serve as the foundation for the development of secondary meanings that possess figurative connotations. It is noted that the actualization of colour meaning is influenced by a combination of linguistic and extralinguistic factors. Methods of conceptualizing colour designations, which are an integral part of the linguistic picture of the world, have been studied. It has been established that in the French and Russian languages the spectrum of colour terms is the same, but at the same time there are significant differences in the perception of colour space among speakers of these languages.
Validation of the Chinese drug hypersensitivity quality of life questionnaire: Role of delabeling
Authors: Mak Hugo W.F. , Chan Elsie T.S. , Yim Jackie S.H. , Lee Elaine , Lam Dorothy L.Y. , Chiang Valerie , Li Philip H. 
Published: February 2024

Background:
The Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q) is not currently available in Chinese. Besides, penicillin allergy (PA) is a worldwide public health challenge, and delabeling inauthentic PA can improve clinical and economic outcomes. However, its effect on health-related quality of life (HRQoL) remains poorly known.

Objective:
The study objective is to translate and validate a Chinese version of DrHy-Q and investigate the effect of PA delabeling on HRQoL using DrHy-Q.

Methods:
A Chinese DrHy-Q was translated then completed by patients with drug allergy labels for psychometric validation. Afterwards, another cohort of patients finished the Chinese DrHy-Q before and after their PA workup for pre–post comparison.

Results:
A total of 130 patients were studied. Sixty-three patients (79.4% female; median age = 59 ± 15 years) completed the Chinese DrHy-Q for validation (mean score = 38.9 ± 23.5). It demonstrated excellent internal consistency (Cronbach α = 0.956; 95% confidence interval [CI], 0.939–0.971) and test–retest reliability (intraclass correlation coefficient = 0.993 [95% CI, 0.969–0.998]). Construct validity was confirmed by its one-dimensional structure in factor analysis. Divergent validity was established because only 2 (out of 9) SF-36 scales showed weak negative correlations to DrHy-Q. Patients with multiple implicated drugs presented significantly higher DrHy-Q scores than those with only a single drug (42.0 ± 22.5 vs 28.7 ± 24.4; P = 0.038), showing discriminant validity. Subsequently, another 67 patients (73.1% female; median age = 56 ± 15 years) underwent PA investigations and completed their pre–post DrHy-Q. A significant drop in DrHy-Q score was shown (40.8 ± 21.7 vs 26.6 ± 22.5; Cohen’s d = 0.964; P < 0.001), reflecting improvement in HRQoL.

Conclusion:
The Chinese DrHy-Q is reliable and valid for HRQoL assessment. PA delabeling significantly benefits patients’ HRQoL. Future larger-scale studies are warranted to corroborate our findings.