bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significant Strain Dissipation via Stiff‐Tough Solid Electrolyte Interphase Design for Highly Stable Alloying Anodes
Authors: Jiang Chunlei , Yan Jiaxiao , Wang Doufeng , Yan Kunye , Shi Lei , Zheng Yongping , Xie Chengde , Cheng Hui‐Ming , Tang Yongbing 
Published: October 2023

AbstractThe pulverization of alloying anodes significantly restricts their use in lithium‐ion batteries (LIBs). This study presents a dual‐phase solid electrolyte interphase (SEI) design that incorporates finely dispersed Al nanoparticles within the LiPON matrix. This distinctive dual‐phase structure imparts high stiffness and toughness to the integrated SEI film. In comparison to single‐phase LiPON film, the optimized Al/LiPON dual‐phase SEI film demonstrates a remarkable increase in fracture toughness by 317.8 %, while maintaining stiffness, achieved through the substantial dissipation of strain energy. Application of the dual‐phase SEI film on an Al anode leads to a 450 % enhancement in cycling stability for lithium storage in dual‐ion batteries. A similar enhancement in cycling stability for silicon anodes, which face severe volume expansion issues, is also observed, demonstrating the broad applicability of the dual‐phase SEI design. Specifically, homogeneous Li−Al alloying has been observed in conventional LIBs, even when paired with a high mass loading LiNi0.5Co0.3Mn0.2O2 cathode (7 mg cm−2). The dual‐phase SEI film design can also accelerate the diffusion kinetics of Li‐ions through interface electronic structure regulation. This dual‐phase design can integrate stiffness and toughness into a single SEI film, providing a pathway to enhance both the structural stability and rate capability of alloying anodes.
Hydrogenation Catalysis by Hydrogen Spillover on Platinum‐Functionalized Heterogeneous Boronic Acid‐Polyoxometalates
Authors: Li Shujun , Ma Yubin , Zhao Yue , Liu Rongji , Zhao Yupeng , Dai Xusheng , Ma Nana , Streb Carsten , Chen Xuenian 
Published: October 2023

AbstractThe activation of molecular hydrogen is a key process in catalysis. Here, we demonstrate how polyoxometalate (POM)‐based heterogeneous compounds functionalized with Platinum particles activate H2 by synergism between a hydrogen spillover mechanism and electron‐proton transfer by the POM. This interplay facilitates the selective catalytic reduction of olefins and nitroarenes with high functional group tolerance. A family of polyoxotungstates covalently functionalized with boronic acids is reported. In the solid‐state, the compounds are held together by non‐covalent interactions (π–π stacking and hydrogen bonding). The resulting heterogeneous nanoscale particles form stable colloidal dispersions in acetonitrile and can be surface‐functionalized with platinum nanoparticles by in situ photoreduction. The resulting materials show excellent catalytic activity in hydrogenation of olefins and nitrobenzene derivatives under mild conditions (1 bar H2 and room temperature).
Forests as Social Mirrors: What do Approaches to Forest Management Tell us About Human Social Relations?
Authors: Walton Andrew 
Published: October 2023

AbstractThere is evidence to suggest that the nature of human impact upon forests, measured both quantitatively and qualitatively, tells a story about dominant social paradigms throughout recent history. In this sense, forests are social mirrors. Collectively, we are consuming ecological resources at 1.5 times the rate they can be replenished, while often simplifying or adversely impacting forest ecosystems. At the same time, ecocentric and enlightened self‐interest movements are emerging, manifest in woodland management approaches that embrace multiple values, ecological sensitivity, and traditional ecological knowledge. The evidence therefore shows that contradictory paradigms exist alongside each other, exerting influence over landscapes at shared temporal and spatial scales simultaneously. Consequently, forest management reflects the sociocultural dynamics of a species experiencing cognitive dissonance; responding to human ideals around the need to tread lightly and the contradictory reality of an ever‐increasing economic output.
Bi‐cuspid TAVR; bye or buy!
Authors: Zahr Firas , Lantz Gurion 
Published: October 2023

Key Points
Mid term data of TAVR in stenotic bicuspid aortic valves is promising both in term of mortality and valve performance.
Many factors should be considered before we generalize these results to all types of bicuspid native valves, TAVR valves, and patient populations.
A randomized trial to SAVR versus TAVR remains the missing piece before we solve this complex clinical equation.
Molybdenum Carbide for Catalytic De/hydrogenation Process: Synthesis, Modulation and Applications
Authors: Jiang Shan , Wu Xiaoping , Liu Xinrui , Ma Wanbing , Song Jiajie , Shu Riyang , Zhang Qian , Qiu Songbai 
Published: October 2023

AbstractThe catalytic de/hydrogenation process is important in the fields of petrochemical refining, fuel synthesis, drug synthesis, CO2 conversion, and hydrogen synthesis, where the construction of low‐cost and high‐efficiency de/hydrogenation catalysts attracting significant attentions. Molybdenum carbide (MoxC), as a non‐noble transition metal carbide catalyst, has been widely investigated for hydrogen activation. Herein, research progress and achievements of molybdenum carbide for catalytic de/hydrogenation are reviewed. Additional attention is paid to the structure and crystal phase of molybdenum carbide, and various modification strategies related to the catalytic activity regulation are summarized. Finally, the application prospect of molybdenum carbide catalysts is also discussed. This review provides a framework reference for further understanding the design and utilization of molybdenum carbide catalysts for catalytic de/hydrogenation and the key research problems to be addressed.
Deposited PtGe Clusters as Active and Durable Catalysts for CO Oxidation**
Authors: Ugartemendia Andoni , Mercero Jose M. , de Cózar Abel , Melander Marko M. , Akola Jaakko , Jimenez‐Izal Elisa 
Published: October 2023

AbstractControl of CO emissions raises serious environmental concerns in the current chemical industry, as well as in nascent technologies based on hydrogen such as electrolyzers and fuel cells. As for now, Pt remains one of the state‐of‐the‐art catalysts for the CO oxidation reaction, but unfortunately, it suffers from CO self‐poisoning. Recently, Pt−Ge alloys were proposed to be an excellent alternative to reduce CO poisoning. This work investigates the impact of Ge content on the CO oxidation kinetics of Pt4Gen subnanoclusters supported on MgO. A Ge concentration dependence of the reaction kinetics is found due to a strong synergy between Pt and Ge. Pt−Ge nanoalloys act as a bifunctional catalyst by displaying dual adsorption sites; i. e., CO is adsorbed on Pt whereas oxygen binds to Ge, forming an alternative oxygen source GeOx. Besides, Ge alloying modifies the electronic structure of Pt (ligand effects) and reduces the affinity to CO. In this way, the competition between CO and O2 adsorption and the overbinding of CO is alleviated, achieving a CO poisoning‐free kinetic regime. Our calculations suggest that Pt4Ge3 is the optimal catalyst, evidencing that alloying composition is a parameter of extreme importance in nanocatalyst design. The work relies on global optimization search techniques to determine the accessibility of multiple structures at different conditions, mechanistic studies and microkinetic modeling.
Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%
Authors: Li Yafeng , Chen Zhenyu , Yan Xingzheng , Ge Ziyi 
Published: October 2023

AbstractDesigning novel nonfullerene acceptors (NFAs) is of vital importance for the development of organic solar cells (OSC). Modification on the side chain and end group are two powerful tools to construct efficient NFAs. Here, based on the high‐performance L8BO, we selected 3‐ethylheptyl to substitute the inner chain of 2‐ethylhexyl, obtaining the backbone of BON3. Then we introduced different halogen atoms of fluorine and chlorine on 2‐(3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene) malononitrile end group (EG) to construct efficient NFAs named BON3‐F and BON3‐Cl, respectively. Polymer donor D18 was chosen to combine with two novel NFAs to construct OSC devices. Impressively, D18:BON3‐Cl‐based device shows a remarkable power conversion efficiency (PCE) of 18.57%, with a high open‐circuit voltage (VOC) of 0.907 V and an excellent fill factor (FF) of 80.44%, which is one of the highest binary PCE of devices based on D18 as the donor. However, BON3‐F‐based device shows a relatively lower PCE of 17.79% with a decreased FF of 79.05%. The better photovoltaic performance is mainly attributed to the red‐shifted absorption, higher electron and hole mobilities, reduced charge recombination, and enhanced molecular packing in the D18:BON3‐Cl films. Also, we performed stability tests on two binary systems; the D18:BON3‐Cl and D18:BON3‐F devices maintain 88.1% and 85.5% of their initial efficiencies after 169 h of storage at 85°C in an N2‐filled glove box, respectively. Our work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3‐Cl for further improvement of PCE.
Improving In Vivo Tumor Accumulation and Efficacy of Platinum Antitumor Agents by Electronic Tuning of the Kinetic Lability
Authors: M Manikandan , Chhatar Sushanta , Gadre Shubhankar , Paul Subhadeep , Vaidya Shreyas P. , Khatri Subhash , Duari Prakash , Kode Jyoti , Ingle Arvind , Kolthur‐Seetharam Ullas , Patra Malay 
Published: October 2023

AbstractThe impact of kinetic lability or reactivity on in vitro cytotoxicity, stability in plasma, in vivo tumor and tissue accumulation, and antitumor efficacy of functional platinum(II) (Pt) anticancer agents containing a O˄O β‐diketonate leaving ligand remain largely unexplored. To investigate this, we synthesized Pt complexes [(NH3)2Pt(L1‐H)]NO3 and [(DACH)Pt(L1‐H)]NO3 (L1=4,4,4‐trifluoro‐1‐ferrocenylbutane‐1,3‐dione, DACH=1R,2R‐cyclohexane‐1,2‐diamine) containing an electron deficient [L1‐H]– O˄O leaving ligand and [(NH3)2Pt(L2‐H)]NO3 and [(DACH)Pt(L2‐H)]NO3 (L2=1‐ferrocenylbutane‐1,3‐dione) containing an electron‐rich [L2‐H]– O˄O leaving ligand. While all four complexes have comparable lipophilicity, the presence of the electron‐withdrawing CF3 group was found to dramatically enhance the reactivity of these complexes toward nucleophilic biomolecules. In vitro cellular assays revealed that the more reactive complexes have higher cellular uptake and higher anticancer potency as compared to their less reactive analogs. But the scenario is opposite in vivo, where the less reactive complex showed improved tissue and tumor accumulation and better anticancer efficacy in mice bearing ovarian xenograft when compared to its more reactive analog. Finally, in addition to demonstrating the profound but contrasting impact of kinetic lability on in vitro and in vivo antitumor potencies, we also described the impact of kinetic lability on the mechanism of action of this class of promising antitumor agents.
Discotic Star Mesogen with Thymine Nucleobases Exhibiting a Rare Gyroid Cubic Mesophase with 3D Conductivity
Authors: Noll Katja , Lambov Martin , Singh Dharmendra Pratap , Lehmann Matthias 
Published: October 2023

AbstractA unique gyroid cubic phase has been discovered for a discotic star mesogen with three covalently attached DNA bases. In this cubic
phase, the conjugated core of the mesogens and the thymine pseudo guests self‐assemble in mirror image continuous networks, representing a semiconducting material with three‐dimensional transport pathways. The hole carrier mobilities are found to be in the typical range of poly(phenylenevinylene) scaffolds. This structure is stabilized by a weak hydrogen bonding between the thymine bases and can be switched to a columnar liquid crystal – thermally and by the addition of complementary adenine guests.
Recent Advances in Zeolites‐Catalyzed Biomass Conversion to Hydroxymethylfurfural: The Role of Porosity and Acidity
Authors: Wang Yanan , Yuan Xiaoxian , Liu Jianxin , Jia Xicheng 
Published: October 2023

AbstractBiomass is an attractive raw material for the production of fuel oil and chemical intermediates due to its abundant reserves, low price, easy biodegradability, and renewable use. Hydroxymethylfurfural (5‐HMF) is a valuable platform chemically derived from biomass that has gained significant research interest owing to its economic and environmental benefits. In this review, recent advances in biomass catalytic conversion systems for 5‐HMF production were examined with a focus on the catalysts selection and feedstocks’ impact on the 5‐HMF selectivity and yield. Specifically, the potential of zeolite‐based catalysts for efficient biomass catalysis was evaluated given their unique pore structure and tunable (Lewis and Brønsted) acidity. The benefits of hierarchical modifications and the interactions between porosity and acidity in zeolites, which are critical factors for the development of green catalytic systems to convert biomass to 5‐HMF efficiently, were summarized and assessed. This Review suggests that zeolite‐based catalysts hold significant promise in facilitating the sustainable utilization of biomass resources.
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
Authors: Schneider Kai Markus , Blank Niklas , Thaiss Christoph A. 
Published: October 2023

AbstractPsychological stress can trigger inflammatory bowel disease (IBD) flares, but the molecular mechanisms have remained unclear. We recently discovered an unexpected function of the enteric nervous system as a relay between stress signals from the brain and intestinal inflammation. Our findings highlight targeting stress‐induced signaling networks as a possible new pillar in the clinical management of IBD.
A case of extranodal NK/T‐cell lymphoma, nasal type, diagnosed by scraping cytology of the maxillary gingiva
Authors: Niwa Hiroe , Mukai Kazumi , Kimura Iyo , Imura Johji 
Published: October 2023

AbstractExtranodal NK/T‐cell lymphoma (ENKTL), nasal type, is often seen in the head and neck region, but there have been rare instances of this disease with initial presentation as a lesion in the oral mucosa. The patient, a woman in her seventh decade of life, presented with an ulcer in the maxillary gingiva, and scraping cytology and biopsy were performed. Cytological specimens showed solitary or small aggregating cells with marked atypia in a necrotic background. Tumor cells were detected that had various nuclear shapes and azure granules in the cytoplasm. Biopsy showed that the tumor cells had diffusely infiltrated or interdigitated into the subepithelium. Immunohistochemistry revealed that the tumor cells had T‐ and NK cell phenotypes and were Epstein–Barr virus‐encoded small RNA (EBER) positive, leading to a diagnosis of ENKTL. Thus, when nonepithelial tumor cells in a necrotic background and prominent atypia are found, as in this case, it is important to carefully observe for azurophil granules in the cytoplasm for differential diagnosis considerations.
One third of cases of new‐onset diabetic ketosis in adults are associated with ketosis‐prone type 2 diabetes—A systematic review and meta‐analysis
Authors: Kovacs Adrienn , Bunduc Stefania , Veres Daniel S. , Palinkas Daniel , Gagyi Endre B. , Hegyi Peter J. , Eross Balint , Mihaly Emese , Hegyi Peter , Hosszufalusi Nora 
Published: October 2023

AbstractAimsKetosis‐prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta‐analysis assessed the prevalence and clinical characteristics of ketosis‐prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.MethodsThe systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis‐prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals.ResultsEleven articles were eligible for meta‐analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%–49%) had ketosis‐prone type 2 diabetes. These patients were older (MD = 11.55 years; 95% CI: 5.5–17.6) and had a significantly higher body mass index (BMI) (MD = 5.48 kg/m2; 95% CI: 3.25–7.72) than those with type 1 diabetes.ConclusionsKetosis‐prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C‐peptide and diabetes‐related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes.
Stem cell‐mediated development, regeneration, chimerism, and aging in the colonial chordate Botryllus schlosseri
Authors: Voskoboynik Ayelet 
Published: October 2023

SummaryStem cells are units of biological organization, responsible for tissue and organ development and regeneration. I study stem cell biology, aging, and the evolution of immunity using the colonial chordate Botryllus schlosseri as a model system. This organism is uniquely suited for this study because it is closely related to vertebrates, undergoes weekly cycles of stem cell mediated regeneration, is long lived and has a recognition system and robust immune system. I have led the Botryllus genome project and developed a novel method to obtain a synthetic long read sequence, identified Botryllus stem cells and stem cell niches, isolated the gene that controls self/non self‐recognition and characterized its immune system on the cellular and molecular levels. Recently, I led the Botryllus atlas project to characterize the two developmental pathways, embryogenesis (sexual) and blastogenesis (asexual), revealing the unique molecular landscapes for each developmental mode and investigated the molecular clock and neurodegeneration pathways in young and old colonies and investigated the molecular clock and neurodegeneration pathways in young and old colonies. These results and the resources we developed are used by my lab and others to further study stem cell and immune cell properties during development, regeneration, transplantation, and aging.
Synthesis, Structural Elucidation, and Cytotoxicity Studies of New Triazolyl Half‐Sandwich RuII, OsII, RhIII and IrIII Complexes
Authors: Chu William K. , Rono Charles K. , Makhubela Banothile C. E. 
Published: October 2023

AbstractHerein, we report the synthesis of a series of nine novel cationic triazole‐based complexes C1–C9 and their anticancer assays against cervical cancer cells (Hela), kidney cancer cells (HEK293), lung cancer cells (A549), and leukemia cells (MT4). The complexes have the formula [MCl(Ar)L]+X−, where M is a platinum group metal‐based cation (RuII, OsII, RhIII, or IrIII), Ar is Cp* for Rh and Ir and p‐cymene for Ru and Os, L is the
‐chelating ligands 1‐benzyl‐4‐(aminomethyl)‐1H‐1,2,3‐triazole (L1) and 1‐picolyl‐4‐phenyl‐1H‐1,2,3‐triazole (L2), and X− is Cl−, BF4−, or BPh4−. The reaction of ligands L1 and L2 with [Ru(p‐cymene)Cl2]2, [Os(p‐cymene)Cl2]2, [Rh(Cp*)Cl2]2, and [Ir(Cp*)Cl2]2 produced the nine cationic complexes (C1–C9) cumulatively. Normal kidney cell lines (BHK21) were included in the assays to assess the selectivity aspect of these complexes to cancer cells. In general, all the compounds displayed low cytotoxicity except for the ruthenium(II) complex C7 (with BPh4− as the counterion), which showed good activity against all the cancer cell lines (EC50 values as low as 9±1.8 μM. Complex C1 with EC50=16±0.5 μM against MT4 gave the highest selectivity towards cancer cells. C7 was also shown to interact with L‐histidine (L‐His), NADH, bovine serum album (BSA) and guanosine 5’‐monophosphate (5’‐GMP). Due to the observed non‐toxicity of most of the complexes against normal cells, selectivity against specific cancer cells, and interaction with imidazole containing biomolecules, this class of complexes may serve as templates in drug development for targeted therapeutics.
Nickel Metallaphotoredox Buchwald–Hartwig Amination Reactions: A Perspective on Irradiation Light Wavelength
Authors: Kuai Meiying , Jia Zihan , Chen Lijie , Gao Shuang , Fang Weiwei 
Published: October 2023

AbstractThe construction of C−N bonds is considered one of the most useful reactions in synthetic chemistry due to their widespread presence in pharmaceuticals, natural products, etc. Pd‐catalyzed Buchwald–Hartwig amination (BHA) has provided the most efficient method to form (hetero)aryl amines but it required strong base and sophisticated ligands. In comparison, the combination of photocatalysis and nickel chemistry has revolutionized catalytic strategies and is emerging as a quintessence to realize BHA, termed as Ni‐metallaphotoredox BHA. To pursue a universal protocol, diverse photocatalysts were designed and employed in Ni‐metallaphotoredox BHA, and smoothly promoted C−N bond formations under irradiation of light from ultraviolet to red light, respectively. Note that the matching of photocatalyst and light was critical for success. Therefore, this review mainly focuses on the discussion of Ni‐metallaphotoredox BHA according to the irradiation light's wavelength, covering ultraviolet, purple, blue, red, and white light as well as solar light. We try to find a clue in the relationship of structure‐photophysical behaviors of photocatalysts under the same or different irradiation light. At last, current limitations and potential trends for advancing Ni‐metallaphotoredox BHA are highlighted. We deem that it could encourage chemists to continue designing suitable photocatalyst for C−N bond formations under sunlight mimicking plants’ photosynthesis.
Spatial regression modeling via the R2D2 framework
Authors: Yanchenko Eric , Bondell Howard D. , Reich Brian J. 
Published: October 2023

AbstractSpatially dependent data arises in many applications, and Gaussian processes are a popular modeling choice for these scenarios. While Bayesian analyses of these problems have proven to be successful, selecting prior distributions for these complex models remains a difficult task. In this work, we propose a principled approach for setting prior distributions on model variance components by placing a prior distribution on a measure of model fit. In particular, we derive the distribution of the prior coefficient of determination. Placing a beta prior distribution on this measure induces a generalized beta prime prior distribution on the global variance of the linear predictor in the model. This method can also be thought of as shrinking the fit towards the intercept‐only (null) model. We derive an efficient Gibbs sampler for the majority of the parameters and use Metropolis–Hasting updates for the others. Finally, the method is applied to a marine protection area dataset. We estimate the effect of marine policies on biodiversity and conclude that no‐take restrictions lead to a slight increase in biodiversity and that the majority of the variance in the linear predictor comes from the spatial effect.