bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weniger arbeiten, mehr verdienen?
Authors: Heeser Alexandra 
Published: November 2023

ZusammenfassungDie 35-Stunden-Woche oder die Vier-Tage-Woche sind auf dem Vormarsch, um die Arbeitsbedingungen in der Pflege zu verbessern und die Work-Life-Balance der Pflegekräfte zu erhöhen – und so auch auf sein eigenes Konto als attraktiver Arbeitgeber einzuzahlen. Doch was hat es damit auf sich?
Enzymatic Kinetic Resolution (EKR) of α-Allenols Enabled by a Commercially Available Immobilized Lipase
Authors: Zhu Can , Zhang Tianyu 
Published: November 2023

AbstractEnzymatic kinetic resolution (EKR) of racemates has been considered as an efficient and scalable technology to deliver enantiopure substances in an environmentally benign way. Herein, we develop a practical EKR of α-allenols enabled by a commercially available immobilized lipase, Lipozyme TL-IM. The stereoselectivity factor (S-factor) of this kinetic resolution (KR) was investigated to reach up to >1000. The robust nature of the EKR strategy is reflected by a broad scope of α-allenol substrates with the excellent control of enantioselectivity. This method offers an alternative approach to access chiral α-allenols, which can be easily transformed into many valuable oxycycles.
Relationship between Age and The Histopathological Features to Chemotherapy Response in Colorectal Cancer Patients: A Prospective Observational Study
Authors: Lukman Kiki , Gunawan Gun Gun , Rudiman Reno , Sribudiani Yunia , Hasibuan Lisa Y. , Dewayani Birgitta M. , Nugraha Prapanca , Primastari Etis 
Published: November 2023

Abstract
Introduction Chemotherapy response in early age-onset colorectal cancer patients is still controversial, and the results of chemotherapy response are unknown. Therefore, the purpose of this study is to determine the relationship between the age of colorectal cancer patients and histopathological features and chemotherapy response.
Methods This is a prospective observational study. The subjects in this study were colorectal cancer patients in the Digestive Surgery division at Tertiary Hospital in West Java from September 2021 to September 2022.
Results There were 86 subjects who underwent chemotherapy in accordance with the inclusion and exclusion criteria. Consisting of 39 patients of early age onset and 44 female patients. The most common histopathological feature in early age onset (EAO) and late age onset (LAO) was adenocarcinoma (25% and 46%, respectively). Stage III colorectal cancer affected 38 patients, while stage IV affected 48 patients. There was a significant relationship between early age onset and late age onset with histological features (p < 0.001). The patients with the highest chemotherapy response had stable diseases in EAO (17 patients) and LAO (20 patients). There was no statistically significant relationship between age, histological features, and stage of colorectal cancer and chemotherapy response (p > 0.05). The results of the ordinal logistic regression test showed no systematic relationship between chemotherapy response and age, histopathological features, gender, or cancer stage (p > 0.05).
Conclusion There was no association between age and histopathologic features with chemotherapy response and there is no difference in chemotherapy response between early and late age onset.
Serrated Polyposis Syndrome: A Literature Review
Authors: Stephanini Guilherme Campos , Pinto Nathan Assis Jordão , Faraco Jarbas , Correa Paulo Alberto Falco Pires 
Published: November 2023

AbstractSerrated polyposis syndrome is considered the most prevalent colonic polyposis syndrome in the world. Its importance has been increasingly discussed due to the significant increase in the risk of developing colorectal cancer in its affected individuals, similarly to other well-known polyposis syndromes, such as familial adenomatous polyposis.Serrated lesions of the colon play a major role in this syndrome represented by hyperplastic polyps, serrated sessile lesions and traditional serrated adenomas. Among these lesions, the sessile serrated lesion stands out, considered the main precursor lesion of the serrated pathway of colon carcinogenesis.Diagnosis of serrated polyposis syndrome is given through colonoscopy examination. Diagnostic criteria are: 1) 5 or more serrated lesions proximal to the rectum, all >4mm in size, with at least two >9mm in size; or 2) 20 serrated lesions of any size located anywhere in the large intestine, with >4 lesions proximal to the rectum.The ideal treatment is removal of all relevant serrated lesions by colonoscopy. In case of failure of endoscopic therapy, surgery is indicated. This manuscript is based on two case reports and a literature review and aims to broaden the discussion about the subject.
How do line extensions impact brand sales? The role of feature similarity and brand architecture
Authors: Sezen Burcu , Pauwels Koen , Ataman Berk 
Published: November 2023

AbstractBrand architecture decisions have important performance implications but have seen little quantitative research. In particular, there is little empirical evidence on how the strength of the link established among clusters of products within the company’s portfolio impact the sales effects of typical marketing actions such as line extensions. This paper quantifies the effect of different brand architecture choices and product feature similarity in moderating the impact of line extensions on brand sales. Based on categorization theory, the authors hypothesize that brand name similarity and feature similarity, both independently, and in interaction, increase brand cannibalization. The empirical analysis in three consumer packaged-goods categories shows that it is more critical to minimize the feature similarity than brand name similarity to limit cannibalization and generate higher incremental sales from line extensions. Controlling for feature similarity, line extensions introduced under sub-brands cause greater cannibalization.
Organic agriculture and agri-food system democracy: an institutional perspective from Kenya
Authors: Canwat Vincent , Onakuse Stephen 
Published: November 2023

AbstractThe discontent with the undemocratic agricultural food system inspired the emergence of many alternative agri-food systems, including organic agriculture. This study analysed how organic agriculture promotes agri-food system democracy concerning traditional knowledge integration, community and women participation, market, and policy integration. The study found that organic agriculture conversion increases traditional knowledge integration, community and women participation, and market integration. Although, it promotes policy integration by contributing to organic standards and policy development, the policy has remained in draft form for too long. The study implies supporting organic agriculture can promote agri-food system democracy, but its potential is compromised by the lack of an approved policy. Thus, stakeholders should increase their advocacy efforts for speedy organic policy approval and broader policy scope, including compensating organic producers for supplying public goods.
On the origin and elimination of cross coupling between tunneling current and excitation in scanning probe experiments that utilize the qPlus sensor
Authors: Schelchshorn Michael , Stilp Fabian , Weiss Marco , Giessibl Franz J. 
Published: November 2023

The qPlus sensor allows for the simultaneous operation of scanning tunneling microscopy (STM) and atomic force microscopy (AFM). When operating a combined qPlus sensor STM/AFM at large tunneling currents, a hitherto unexplained tunneling current-induced cross coupling can occur, which has already been observed decades ago. Here, we study this phenomenon both theoretically and experimentally; its origin is voltage drops on the order of μV that lead to an excitation or a damping of the oscillation, depending on the sign of the current. Ideally, the voltage drops would be phase-shifted by π/2 with respect to a proper phase angle for driving and would, thus, not be a problem. However, intrinsic RC components in the current wiring lead to a phase shift that does enable drive or damping. Our theoretical model fully describes the experimental findings, and we also propose a way to prevent current-induced excitation or damping.
Study on the influence of building aerodynamic shadows on the heat transfer performance of natural draft dry cooling towers
Authors: Zhao Jincheng , Ma Mingrui , Wang Zhichao , Tan Dunhu , Chen Lin , Zhang Feng , Han Xu , Wang Zhi 
Published: November 2023

Previous studies have shown that the heat transfer of air cooling towers is mainly affected by crosswind. To improve the cooling performance of air-cooled towers under crosswind and the efficiency of power plants, this paper studies the influence mechanism of buildings on the heat dissipation performance of natural draft dry cooling towers (NDDCTs). The numerical simulation of a 2 × 1000 MW NDDCT is carried out to analyze the distribution of the aerodynamic shadow area and its influence on the heat transfer performance of the NDDCT. The study found that at a wind speed of 12 m/s, the heat dissipation efficiency of the NDDCT under the influence of the original building decreased by 4.74%, and the total ventilation volume decreased by 2595.76 kg/s. When the NDDCT was located in the aerodynamic shadow wake area of the building, the heat dissipation efficiency increased by 8.36%. This shows that the aerodynamic shadow area of the building will lead to deflection deceleration and a steady flow effect of the flow field near the tower base, which has a double-sided effect on the heat transfer of the NDDCT. By adjusting the interference of the aerodynamic shadow wake area of the building on the NDDCT, the high wind speed sensitivity and the heat dissipation deviation of the two towers can be reduced.
Research progress of biomass-derived carbon for the supercapacitors
Authors: Zhang Miao , Peng Lihua 
Published: November 2023

Abstract
In order to fulfil the requirements of various equipment in different fields for energy storage components, there is an increasing number of studies being conducted on the development of electrode materials for supercapacitors. At present, carbon materials used in electrode components in supercapacitors are mostly graphene, porous carbon, activated carbon, and carbon nanotubes. Due to the fast advancements in modern technology and science, which have stimulated the demand for sustainable and eco-friendly energy storage materials, biomass-derived carbon materials have gradually emerged in the public eye. The carbon source of biomass-derived carbon is usually a natural substance, which has advantages such as low cost, easy availability, and environmental friendliness. Due to the diversity of material structures, the required electrode materials can be designed and prepared according to performance requirements. At the same time, biomass-derived carbon is also capable of being combined alongside various electrode materials to create asymmetric capacitors, combining the advantages of the two to enhance capacitor electrochemical performance. This article first introduces different sources of biomass-derived carbon-based electrode materials and compares their electrochemical performance. Then, based on various research results, the factors that affect their electrochemical performance are discussed in detail. Then, the preparation methods of biomass-derived carbon electrode materials are introduced, and the specific requirements, advantages and disadvantages of different preparation methods are briefly analyzed. The application of biomass-derived carbon electrode materials in supercapacitors in combination with other materials is listed. Finally, a summary and outlook of the current research status are provided to provide a reference for the rational design of biomass carbon supercapacitors in the future.
Predictors of U.S. public support for climate aid to developing countries
Authors: Ansah Patrick O , Campbell Eryn , Kotcher John , Rosenthal Seth A , Leiserowitz Anthony , Maibach Edward 
Published: November 2023

Abstract
Effectively responding to global warming requires mitigation and adaptation efforts worldwide. Although developed countries have pledged substantial financial support to help developing countries respond to climate change, these pledges have yet to be fulfilled. A majority of American voters support providing aid to developing nations, however, levels of support differ sharply between Democrats and Republicans. To investigate the predictors of support for climate aid among registered voters in the United States and to assess the effect of political party identification, we conducted hierarchical regression and relative weight analysis on a nationally representative sample of U.S. registered voters (n = 898) surveyed in 2021. Among all voters, the predictors of support for climate aid were: party identification (with more support among Democrats), perceived risk to developing countries, worry about global warming, injunctive beliefs that the U.S. should do more, and global warming belief certainty. Among Democrats, the predictors were: perceived risk to the U.S., worry, injunctive beliefs the U.S. should do more, education, and income. Among Republicans, the predictors were: perceived risk to developing countries, and injunctive beliefs the U.S. should do more. These findings have both theoretical and practical relevance for efforts to build public support for development assistance aimed at reducing climate change.
Plant-based carbon dots are a sustainable alternative to conventional nanomaterials for biomedical and sensing applications
Authors: Priya S Shanmuga , S R Suseem 
Published: November 2023

Abstract
Carbon dots are small carbon-based particles with unique properties that make them useful in various applications. Some advantages include low toxicity, bio-compatibility, excellent photo luminescence, high stability, and ease of synthesis. These features make them promising for biomedical imaging, drug delivery, and optoelectronic devices. Carbon dots derived from plants have several advantages, including their low toxicity, biocompatibility, and renewable sources. They also have excellent water solubility and high stability and can be easily synthesized using simple and low-cost methods. These properties make them promising candidates for various biomedicine, sensing, and imaging applications. Plant-based carbon dots have shown great potential in metal sensing and bio-imaging applications. They can act as efficient sensors for detecting heavy metals due to their strong chelation and fluorescence properties. This article showcases plant-based carbon dots, emphasizing their low toxicity, biocompatibility, renewability, and potential in metal sensing and bio-imaging. It aims to illustrate their versatile applications and ongoing research for broader use. The current investigation explores their full potential and develops new synthesis and application methods.
LncPCD: a manually curated database of experimentally supported associations between lncRNA-mediated programmed cell death and diseases
Authors: He Ni , Li Danyang , Xu Fanfan , Jin Jingnan , Li Lifang , Tian Liting , Chen Biying , Li Xiaoju , Ning Shangwei , Wang Lihua , Wang Jianjian 
Published: November 2023

Abstract
Programmed cell death (PCD) refers to controlled cell death that is conducted to keep the internal environment stable. Long noncoding RNAs (lncRNAs) participate in the progression of PCD in a variety of diseases. However, no specialized online repository is available to collect and store the associations between lncRNA-mediated PCD and diseases. Here, we developed LncPCD, a comprehensive database that provides information on experimentally supported associations of lncRNA-mediated PCD with diseases. The current version of LncPCD documents 6666 associations between five common types of PCD (apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis) and 1222 lncRNAs in 331 diseases. We also manually curated a wealth of information: (1) 7 important lncRNA regulatory mechanisms, (2) 310 PCD-associated cell types in three species, (3) detailed information on lncRNA subcellular locations and (4) clinical applications for lncRNA-mediated PCD in diseases. Additionally, 10 single-cell sequencing datasets were integrated into LncPCD to characterize the dynamics of lncRNAs in diseases. Overall, LncPCD is an extremely useful resource for understanding the functions and mechanisms of lncRNA-mediated PCD in diseases.
Database URL: http://spare4.hospital.studio:9000/lncPCD/Home.jsp
Cardiac output drop reflects circulatory attrition after Fontan completion: serial cardiac magnetic resonance study
Authors: Arrigoni Sara C , Berger Rolf M F , Ebels Tjark , Postmus Douwe , Hoendermis Elke S , Schoof Paul H , Willems Tineke P , van Melle Joost P 
Published: November 2023

Abstract

Aims
Cardiac magnetic resonance (CMR) imaging is a main diagnostic tool in the follow-up of Fontan patients. However, the value of serial CMR for the evaluation of Fontan attrition is unknown. The aim of this prospective study of serial CMR is to describe the analysis of time-dependent evolution of blood flow distribution, ventricular volumes, and function in patients after Fontan completion.

Methods and results
In this prospective single-centre study, between 2012 and 2022, 281 CMR examinations were performed in 88 Fontan patients with distribution of blood flows, measurements of ventricular volumes, and ejection fraction. Linear mixed model regression for repeated measurements was used to analyse changes of measurements across serial CMR examinations. During a time interval of 10 years, the median number of CMR per patient was 3 (range 1–5). Indexed flow of ascending aorta, caval veins, and pulmonary arteries decreased significantly across serial CMR examinations. Although a decrease of mean indexed aortic flow (3.03 ± 0.10 L/min/m2 at first CMR vs. 2.36 ± 0.14 L/min/m2 at fourth CMR, P &lt; 0.001) was observed, ejection fraction did not decline (50 ± 1% at first CMR vs. 54 ± 2% at fourth CMR, P = 0.070). Indexed ventricular volumes did not differ significantly across serial CMR examinations.

Conclusion
The decrease of indexed aortic and cavopulmonary flows reflects the attrition of univentricular circulation and can be detected by means of serial CMR. Ventricular systolic dysfunction does not contribute significantly to this attrition. In order to detect significant change of indexed aortic flow, we recommend performing serial CMR as routine practice in the Fontan population.
Senescence evolution under the catastrophic accumulation of deleterious mutations
Authors: Aubier Thomas G , Galipaud Matthias 
Published: November 2023

Abstract
For aging to evolve, selection against mortality must decrease with age. This prevailing view in the evolutionary theory of senescence posits that mutations with deleterious effects happening late in life—when purging selection is weak—may become fixed via genetic drift in the germline, and produce a senescent phenotype. Theory, however, has focused primarily on growing populations and the fate of single deleterious mutations. In a mathematical model, we demonstrate that relaxing both of these simplifying assumptions leads to unrealistic outcomes. In density-regulated populations, previously fixed deleterious mutations should promote the fixation of other deleterious mutations that lead to senescence at ever younger ages, until death necessarily occurs at sexual maturity. This sequential fixation of deleterious mutations is not promoted by a decrease in population size, but is due to a change in the strength of selection. In an individual-based model, we also show that such evolutionary dynamics should lead to the extinction of most populations. Our models therefore make rather unrealistic predictions, underlining the need for a reappraisal of current theories. In this respect, we have further assumed in our models that the deleterious effects of mutations can only occur at certain ages, marked, for instance, by somatic or physiological changes. Under this condition, we show that the catastrophic accumulation of deleterious mutations in the germline can stop. This new finding emphasizes the importance of investigating somatic factors, as well as other mechanisms underlying the deleterious effects of mutations, to understand senescence evolution. More generally, our model therefore establishes that patterns of senescence in nature depend not only on the decrease in selection strength with age but also on any mechanism that stops the catastrophic accumulation of mutations.
Cytogenetics of the Hybridogenetic Frog Pelophylax grafi and Its Parental Species Pelophylax perezi
Authors: Dudzik Anna , Dedukh Dmitrij , Crochet Pierre-André , Rozenblut-Kościsty Beata , Rybka Hanna , Doniol-Valcroze Paul , Choleva Lukáš , Ogielska Maria , Chmielewska Magdalena 
Published: November 2023

Abstract
Hybrid taxa from the genus Pelophylax can propagate themselves in a modified way of sexual reproduction called hybridogenesis ensuring the formation of clonal gametes containing the genome of only one parental (host) species. Pelophylax grafi from South-Western Europe is a hybrid composed of P. ridibundus and P. perezi genomes and it lives with a host species P. perezi (P-G system). Yet it is unknown, whether non-Mendelian inheritance is fully maintained in such populations. In this study, we characterize P. perezi and P. grafi somatic karyotypes by using comparative genomic hybridization, genomic in situ hybridization, fluorescent in situ hybridization, and actinomycin D-DAPI. Here, we show the homeology of P. perezi and P. grafi somatic karyotypes to other Pelophylax taxa with 2n = 26 and equal contribution of ridibundus and perezi chromosomes in P. grafi which supports F1 hybrid genome constitution as well as a hemiclonal genome inheritance. We show that ridibundus chromosomes have larger regions of interstitial (TTAGGG)n repeats flanking the nucleolus organizing region on chromosome no. 10 and a high quantity of AT pairs in the centromeric regions. In P. perezi, we found species-specific sequences in metaphase chromosomes and marker structures in lampbrush chromosomes. Pericentromeric RrS1 repeat sequence was present in perezi and ridibundus chromosomes, but the blocks were stronger in ridibundus. Various cytogenetic techniques applied to the P-G system provide genome discrimination between ridibundus and perezi chromosomal sets. They could be used in studies of germ-line cells to explain patterns of clonal gametogenesis in P. grafi and broaden the knowledge about reproductive strategies in hybrid animals.