bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiphysics Modeling Investigation of Wellbore Storage Effect and Non‐Darcy Flow
Authors: He Yu , Guo Quan , Liu Yuzheng , Huang Haiying , Hou Deyi , Luo Jian 
Published: January 2024

AbstractThis study presents a comprehensive investigation of wellbore storage effects and non‐Darcy flow in pumping well systems using a multiphysics numerical model. The model incorporates the Reynolds‐averaged Navier‐Stokes equations coupled with a moving free surface to simulate the flow field and drawdown in the wellbore. Hydraulic behavior of the system, including well and aquifer drawdown, pumped water ratio, aquifer flow nonlinearity, and wellbore flow field, is analyzed and compared with simplified 1‐D models. This study highlights the presence of a vortex in the wellbore flow field induced by large Reynolds number and the uneven stress distribution at the screen. This vortex influences the wellbore drawdown and introduces 2‐D flow in the surrounding aquifer, which further contributes to the longer travel paths for groundwater particles and increased hydraulic pressure consumption. The results show that non‐Darcy flow, coupled with wellbore storage effects, leads to higher drawdown in the pumping well compared to Darcy flow cases. The aquifer drawdown exhibits a similar temporal pattern but with decreasing deviation at larger distances due to the cone of depression. The pumped water ratio indicates the challenge of supplying outflow at the intake from aquifer storage, with nonlinear flow resulting in a smaller ratio compared to linear cases. A nonlinearity ratio is defined to illustrate the expansion of nonlinear flow regions over time, their convergence to a predictable quasi‐steady‐state shape, which is influenced by the Forchheimer parameter, and the gradual transition to Darcy flow away from the wellbore.
Distributed power analysis attack on SM4 encryption chip
Authors: Gong Haoran , Ju Tailiang 
Published: January 2024

AbstractEncryption chips are specialized integrated circuits that incorporate encryption algorithms for data encryption and decryption, ensuring data confidentiality and security. In China, the domestic SM4 algorithm is commonly utilized, as opposed to the international AES encryption algorithm. These widely implemented encryption standards have been proven to be difficult to crack through crypt analysis methods Currently, power consumption side-channel attacks are the most prevalent method. They involve capturing power consumption data during the encryption process and subsequently recovering the encryption key from this data. The two leading methods are Differential Power Analysis (DPA) and machine learning techniques. DPA does not necessitate prior knowledge but relies heavily on the number of power consumption curves. With only 50 power consumption data points, the accuracy is a mere 80%. Machine learning methods require prior knowledge, achieving an accuracy rate above 95% with only 30 power traces, albeit with training times typically exceeding 15 min. In this paper, a distributed energy analysis attack approach was presented based on Correlation Power Analysis (CPA). The power consumption data was divided into 16 subsets, with each subset corresponding to 8 bytes of the key. By training each subset separately, the 8-byte key’s corresponding power consumption data is reduced to only 100 dimensions, resulting in a 76% decrease in cracking time and a 3% improvement in cracking accuracy rate.This article also trains a more complex 256 classification model to directly crack the final key, achieving a success rate of 28% in cracking 128-bit passwords with only 1 power trace
Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study
Authors: Yang Juntao , Zhou Jiedong , Yang Jie , Lou Haifei , Zhao Bingjie , Chi Jufang , Tang Weiliang 
Published: January 2024

AbstractPrevious intervention studies have shown some benefits of dark chocolate for the cardiovascular system, but it has not been established whether dark chocolate intake is associated with the risk of cardiovascular diseases (CVDs). To investigate the causality between dark chocolate intake and the risk of CVDs, a Mendelian randomization (MR) study was conducted. We obtained summary-level data on dark chocolate intake and CVDs from publicly available genome-wide association studies. In this MR study, the main approach was to use a fixed-effect model with inverse variance weighted (IVW) and evaluate the robustness of the results via sensitivity analysis. We found that dark chocolate intake was significantly associated with the reduction of the risk of essential hypertension (EH) (OR = 0.73; 95% CI 0.60–0.88; p = 1.06 × 10−3), as well as with the suggestive association to the reduced risk of venous thromboembolism (OR = 0.69; 95% CI 0.50–0.96; p = 2.81 × 10−2). However, no association was found between dark chocolate intake and the other ten CVDs. Our study provides evidence for a causality between dark chocolate intake and a reduced risk of EH, which has important implications for the prevention of EH in the population.
The role of graft T-cell size in patients receiving alemtuzumab serotherapy for non-malignant disorders: results of an institutional protocol
Authors: Pandrowala Ambreen , Khan Sanna , Kataria Darshan , Kakunje Manasa , Mishra Varsha , Mamtora Dhruv , Mudaliar Sangeeta , Bodhanwala Minnie , Agarwal Bharat , Hiwarkar Prashant 
Published: January 2024

AbstractAlthough graft T cells assist in engraftment, mediate antiviral immune-reconstitution, and cause graft-versus-host disease, graft size is not determined by T-cell content of the graft. The conventional method of graft size determination based on CD34+ cells with alemtuzumab serotherapy is associated with delayed immune reconstitution, contributing to an increased risk of viral infections and graft failure. Alemtuzumab, a long half-life anti-CD52 monoclonal antibody is a robust T-cell depleting serotherapy, and relatively spares memory-effector T cells compared to naïve T cells. We therefore hypothesized that graft size based on T-cell content in patients receiving peripheral blood stem cell graft with alemtuzumab serotherapy would facilitate immune-reconstitution without increasing the risk of graft-versus-host disease. We retrospectively analysed twenty-six consecutive patients with non-malignant disorders grafted using alemtuzumab serotherapy and capping of graft T cells to a maximum of 600 million/kg. The graft T-cell capping protocol resulted in early immune-reconstitution without increasing the risk of severe graft-versus-host disease. Graft T-cell content correlated with CD4+ T-cell reconstitution and acute graft-versus-host disease. The course of CMV viraemia was predictable without recurrence and associated with early T-cell recovery. No patient developed chronic graft-versus-host disease. Overall survival at one year was 100% and disease-free survival was 96% at a median of 899 days (range: 243–1562). Graft size determined by peripheral blood stem cell graft T-cell content in patients receiving alemtuzumab serotherapy for non-malignant disorders is safe and leads to early T-cell immune-reconstitution with excellent survival outcomes.
Unravelling the temporal and spatial variation of fungal phylotypes from embryo to adult stages in Atlantic salmon
Authors: Lokesh Jep , Siriyappagouder Prabhugouda , Fernandes Jorge M. O. 
Published: January 2024

AbstractEarly microbial colonization has a profound impact on host physiology during different stages of ontogeny. Although several studies have focused on early bacterial colonization and succession, the composition and role of fungal communities are poorly known in fish. Here, we sequenced the internal transcribed spacer 2 (ITS2) region of fungi to profile the mycobiome associated with the eggs, hatchlings and intestine of Atlantic salmon at various freshwater and marine stages. In most of the stages studied, fungal diversity was lower than bacterial diversity. There were several stage-specific fungal phylotypes belonging to different stages of ontogeny but some groups, such as Candida tropicalis, Saccharomyces cerevisiae, Alternaria metachromatica, Davidiella tassiana and Humicola nigrescens, persisted during successive stages of ontogeny. We observed significant changes in the intestinal fungal communities during the first feeding. Prior to first feeding, Humicola nigrescens dominated, but Saccharomyces cerevisiae (10 weeks post hatch) and Candida tropicalis (12 weeks post hatch) became dominant subsequently. Seawater transfer resulted in a decrease in alpha diversity and an increase in Candida tropicalis abundance. We also observed notable variations in beta diversity and composition between the different farms. Overall, the present study sheds light on the fungal communities of Atlantic salmon from early ontogeny to adulthood. These novel findings will also be useful in future studies investigating host-microbiota interactions in the context of developing better nutritional and health management strategies for Atlantic salmon farming.
Exosomal microRNAs as biomarkers for viral replication in tofacitinib-treated rheumatoid arthritis patients with hepatitis C
Authors: Liao Tsai-Ling , Chen I-Chieh , Chen Hong-Wei , Tang Kuo-Tung , Huang Wen-Nan , Chen Yi-Hsing , Chen Yi-Ming 
Published: January 2024

AbstractNotwithstanding recent advances in direct antiviral specialists (DAAs) for hepatitis C infection (HCV), it is yet a pervasive overall issue in patients with rheumatoid arthritis (RA). Exosomal microRNAs (miRNAs) is associated with HCV infection. However, it remains unknown how miRNAs respond following biologic disease-modifying antirheumatic drug (bDMARD) and targeted synthetic DMARD (tsDMARD) treatment in HCV patients with RA. We prospectively recruited RA patients taking anti-tumor necrosis factor-α (TNF-α) inhibitors rituximab (RTX) and tofacitinib. The serum hepatitis C viral load was measured using real-time quantitative reverse transcriptase PCR before and 6 months after bDMARD and tsDMARD therapy. HCV RNA replication activity was measured using an HCV-tricistronic replicon reporter system, and quantitative analysis of hsa-mir-122-5p and hsa-mir-155-5p in patients was performed using quantitative PCR. HCV RNA replication in hepatocytes was not affected by tofacitinib or TNF-α inhibitor treatment. Hsa-mir-155-5p and hsa-mir-122-5p were significantly expanded in RA patients with HCV as compared with those without HCV. We observed a dramatic increase in hsa-mir-122-5p and a decrease in hsa-mir-155-5p expression levels in patients taking RTX in comparison with other treatments. Finally, a reduction in hsa-mir-122-5p and an increase in hsa-mir-155-5p were observed in a time-dependent manner after tofacitinib and DAA therapy in RA-HCV patients. These results showed that hsa-mir-155-5p and hsa-mir-122-5p were significantly increased in RA-HCV patients as compared with those without HCV after taking tofacitinib. Hsa-mir-155-5p and hsa-mir-122-5p may be potential biomarkers for treatment efficacy in RA patients with HCV.
Transport through a correlated polar side-coupled quantum dot transistor in the presence of a magnetic field and dissipation
Authors: Sharma Hemant Kumar , Kalla Manasa , Chatterjee Ashok 
Published: January 2024

AbstractNon-equilibrium magneto-transport properties of a quantum dot dimer transistor are studied in the presence of electron–electron and electron–phonon interactions and the interaction of the dimer phonons with the substrate phonon bath that gives rise to dissipation. The entire system is modeled by the Anderson–Holstein–Caldeira–Leggett Hamiltonian where the Caldeira–Leggett term takes care of the damping. The electron–phonon interaction is dealt with the Lang–Firsov transformation and the electron–electron interaction is treated at the mean-field level. The transport problem is studied using the Keldysh non-equilibrium Green function theory and the effects of electron–electron interaction, external magnetic field, electron–phonon interaction and damping on spectral function, tunneling current and differential conductance of the dimer transistor are calculated.
Experimental, predictive and RSM studies of H2 production using Ag-La-CaTiO3 for water-splitting under visible light
Authors: Ragab Safaa , Elkatory Marwa R. , Hassaan Mohamed A. , El Nemr Ahmed 
Published: January 2024

AbstractAg-La-CaTiO3 was used in place of sacrificial agents to assess the influence of operational factors on hydrogen generation in a photocatalytic water splitting system. After being synthesized, the physicochemical features of this substance were accurately described. Several characterization techniques including UV–Vis spectroscopy, FTIR, XRD, XPS, EDX, SEM, TGA, DRS and BET were applied to study the prepared Ag-La-CaTiO3 photocatalyst. Ag-La-CaTiO3 shows a band in the visible wavelength between 400 and 800 nm at < 560 nm compared to the main CaTiO3 band at 350 nm. Ag 4d5s electrons transition to the conduction band (CB), which is responsible for the absorption band at ~ 560 nm (> 2.21 eV). The effects of catalyst concentration, light intensity, and beginning solution pH on the H2 generation rate may all be evaluated simultaneously using experimental design procedures. Up to a maximum threshold, where a drop in the rate of gas evolution occurs, it was confirmed that the increase in catalyst dose positively affects system productivity. The initial solution pH plays a crucial role in H2 production, and pH = 4 and 10 are the optimum pH with a higher yield of H2 production. The highest total H2 production rate, 6246.09 μmol, was obtained using a catalyst concentration of 700 mg and solution pH equal to 10 under 1200 W Vis lamp for 3 h. For prediction and optimization, a D-Optimal design was applied and the optimal results were pH 4, the catalyst dose of 645.578 mg and 1200 W with H2 production of 6031.11 μmol.
A novel plant growth-promoting rhizobacterium, Rhizosphaericola mali gen. nov., sp. nov., isolated from healthy apple tree soil
Authors: Kim Han Sol , Kim Ji-Sun , Suh Min Kuk , Eom Mi Kyung , Lee Jiyoung , Lee Jung-Sook 
Published: January 2024

AbstractThe rhizosphere microbial community is closely associated with plant disease by regulating plant growth, agricultural production, nutrient availability, plant hormone and adaptation to environmental changes. Therefore, it is very important to identify the rhizosphere microbes around plant roots and understand their functions. While studying the differences between the rhizosphere microbiota of healthy and diseased apple trees to find the cause of apple tree disease, we isolated a novel strain, designated as B3-10T, from the rhizosphere soil of a healthy apple tree. The genome relatedness indices between strain B3-10T and other type species of family Chitinophagaceae were in the ranges of 62.4–67.0% for ANI, 18.6–32.1% for dDDH, and 39.0–56.6% for AAI, which were significantly below the cut‑off values for the species delineation, indicating that strain B3-10T could be considered to represent a novel genus in family Chitinophagaceae. Interestingly, the complete genome of strain B3-10T contained a number of genes encoding ACC-deaminase, siderophore production, and acetoin production contributing to plant-beneficial functions. Furthermore, strain B3-10T was found to significantly promote the growth of shoots and roots of the Nicotiana benthamiana, which is widely used as a good model for plant biology, demonstrating that strain B3-10T, a rhizosphere microbe of healthy apple trees, has the potential to promote growth and reduce disease. The phenotypic, chemotaxonomic, phylogenetic, genomic, and physiological properties of this plant growth-promoting (rhizo)bacterium, strain B3-10T supported the proposal of a novel genus in the family Chitinophagaceae, for which the name Rhizosphaericola mali gen. nov., sp. nov. (= KCTC 72123T = NBRC 114178T).
Spatial activity mapping of ß-mannanase on soybean seeds
Authors: Rueckel Markus , Janson Sven , Solbak Arne , Fickler Anna 
Published: January 2024

AbstractFor farm animals the supplementation of exogenous enzymes, like ß-mannanase, to soybean-based diets is beneficial to improve feed digestibility. In order to unravel the effect of ß-mannanase on soybean meal’s cell structure, a novel imaging concept was developed which allows visualizing the spatial activity pattern of ß-mannanase with high sensitivity by fluorescence microscopy before any visible degradation of the cellular structure occurs. It is based on fluorescence labeling of newly formed reducing ends of ß-mannanase-hydrolyzed polysaccharides after the native reducing ends of all polysaccharides present were chemically reduced. It was revealed that ß-mannanase is not only active at the cell wall but also at previously unknown sites, like the middle lamella and, most prominently, at an intracellular matrix enclosing the protein storage vacuoles. Based on these findings it can be hypothesized that the evaluated ß-mannanase can degrade the enclosing matrix of encapsulated proteins and the cell wall structure and thereby improves efficiency of feed utilization.
Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer’s disease
Authors: Altunkaya Alp , Deichsel Cassandra , Kreuzer Matthias , Nguyen Duy-Minh , Wintergerst Ann-Marie , Rammes Gerhard , Schneider Gerhard , Fenzl Thomas 
Published: January 2024

AbstractDemographic changes will expand the number of senior citizens suffering from Alzheimer's disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset and progression of AD. AD mouse models may provide insights into mechanisms of AD-related sleep impairments. Such models may also help to establish new biomarkers predicting AD onset and monitoring AD progression. The present study aimed to establish sleep-related face validity of a widely used mouse model of AD (ArcAβ model) by comprehensively characterizing its baseline sleep/wake behavior. Chronic EEG recordings were performed continuously on four consecutive days in freely behaving mice. Spectral and temporal sleep/wake parameters were assessed and analyzed. EEG recordings showed decreased non-rapid eye movement sleep (NREMS) and increased wakefulness in transgenic mice (TG). Vigilance state transitions were different in TG mice when compared to wildtype littermates (WT). During NREMS, TG mice had lower power between 1 and 5 Hz and increased power between 5 and 30 Hz. Sleep spindle amplitudes in TG mice were lower. Our study strongly provides sleep-linked face validity for the ArcAβ model. These findings extend the potential of the mouse model to investigate mechanisms of AD-related sleep impairments and the impact of sleep impairments on the development of AD.
Predicting treatment outcomes of intravitreal brolucizumab for polypoidal choroidal vasculopathy through noninvasive assessment of polypoidal lesion blood flow with optical coherence tomography angiography
Authors: Hoshino Junki , Matsumoto Hidetaka , Nakamura Kosuke , Akiyama Hideo 
Published: January 2024

AbstractWe investigated the assessment of blood flow within polypoidal lesions using optical coherence tomography angiography (OCTA) to determine intravitreal brolucizumab (IVBr) efficacy for treating polypoidal choroidal vasculopathy (PCV). We retrospectively studied 46 eyes with PCV that completed 1-year IVBr treatment. Blood flow signals within polypoidal lesions were evaluated using OCTA after loading-phase treatment, and 1-year outcomes were compared between eyes in which blood flow signals disappeared versus persisting. After loading-phase treatment, blood flow signals within polypoidal lesions disappeared in 31 eyes and persisted in 15. In the former group, visual acuity improved significantly throughout the year (P < 0.01), while in the latter there was no significant difference between baseline and after 1 year. The total number of injections was significantly lower with than without disappearance of blood flow signals (6.0 vs. 6.9, P < 0.01). The intended injection interval at the last visit was significantly longer in the former than in the latter group (15.7 weeks vs. 12.5 weeks, P < 0.01). These results indicate that PCV cases showing disappearance of blood flow signals within polypoidal lesions by OCTA after loading-phase treatment had favorable 1-year outcomes of IVBr. Therefore, evaluating blood flow within polypoidal lesions by OCTA may allow noninvasive prediction of PCV treatment outcomes.
Multicomponent reactions to access S-aryl dithiocarbamates via an electron donor–acceptor complex under open-to-air conditions
Authors: Tang Yisong , Cai Yougen , Xie Zhiwei , Gao Zishan , Chen Xiaoyun , Yi Jun 
Published: January 2024

An efficient transition-metal/photocatalyst-free visible-light-driven one-pot three-component reaction between thianthrenium salts, carbon disulfide and amines under air atmosphere for the preparation of S-aryl dithiocarbamates is developed.
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool
Authors: Gillard Justine , Leclercq Isabelle A. 
Published: January 2024

Abstract
Bile acids are signaling mediators, enabling intricate communication between tissues and the gut microbiota, and are involved in the pathophysiology of several immune and metabolic disorders. In this commentary, we discuss the importance of the gut microbiota in the Cyp2c70 knock-out mice, which are considered as a promising ‘humanized’ experimental resource for studying bile acids and their role in pathological conditions. We also discuss how Cyp2c70-deficient mice contribute to enhancing the translatability of preclinical studies in murine models to humans.
A detection and rerouting mechanism for platoon control of non‐linear autonomous vehicles under denial of service attacks
Authors: Zhang Xiaofei , Du Haiping , Jia Zhijuan , He Yuchu , Yang Yanyan 
Published: January 2024

AbstractThis paper presents a novel detection and rerouting mechanism for distributed adaptive platoon control of non‐linear autonomous connected vehicles under denial of service (DoS) attacks. DoS attacks can cause delays or losses of data packets due to blocked communication channels, leading to reducing platoon performance or even collisions among vehicles. To tackle this issue, the proposed mechanism detects and reroutes communication topology depending on the real‐time topology and the number of link failures. Real‐time detection divides the scenario of DoS attacks into three parts. According to the different scenarios, rerouting mechanisms will be utilized. A controller adapted to real‐time variable communication topology is also designed in this scheme. The adjacency matrix of the real‐time communication topology generated by the rerouting mechanism is used to update the controller so that the platoon can remain in a stable state without being affected by DoS attacks. In addition, the sliding mode controller and the observer are designed by solving linear matrix inequalities, and the platoon stability and internal stability are proven. Numerical simulation studies demonstrate that the proposed mechanism and control design can reduce the vehicle state estimate error and platoon‐tracking error to ideal states under DoS attacks. The proposed method solves the problem that the existing methods have not considered the number of link failures and the inability to restore communication when the communication topology is paralyzed.
Global strategy for robust air‐light estimation in dehazing
Authors: Zhu Zhu , Zhang Xiaoguo 
Published: January 2024

AbstractThis letter proposes a novel approach to enhance the robustness of air‐light estimation for dehazing. Unlike most existing methods, it employs a global strategy, considering all pixels instead of specific individual ones, for recovering air‐light. Through an iterative algorithm via the Gray World (GW), the authors extract the air‐light orientation from the entire image. Next, a global detail‐preserving algorithm is designed to determine the optimal magnitude of air‐light. Experimental results on a diverse set of hazy images reveal that the authors’ method outperforms other state‐of‐the‐art alternatives, highlighting the advantage of air‐light estimation using the entire image information.