bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ab-initio study on structural, magnetic, electronic and optical properties of SrCo1−xAxO3 (A = Fe or Cr, x = 0.125 and 0.25)
Authors: Younsi Ahmed Memdouh , Rabehi Abdelaziz , Gacem Lakhdar , Soltani Mohamed Toufik 
Published: October 2023

Herein, a first-principles study on the structural, electronic, optical and magnetic properties of SrCo[Formula: see text]AxO3 ([Formula: see text] or Cr, [Formula: see text] and 0.25) was conducted. For all calculations, ultrasoft pseudo-potentials plane wave (USPPW) and the generalized gradient approximation (GGA) with the default exchange-correlation parameterization of Perdew–Burke–Ernzerhof (PBE) were employed and with Hubbard correction. The crystal structures of SrCo[Formula: see text]A[Formula: see text]O3 and SrCo[Formula: see text]A[Formula: see text]O3 ([Formula: see text] or Cr) are determined as a supercell of [Formula: see text] cell cubic perovskite structure (Pm-3m) with symmetry space group No. 221. No energy gap was observed at the Fermi level for both SrCo[Formula: see text]Cr[Formula: see text]O3 and SrCo[Formula: see text]Cr[Formula: see text]O3 compounds, indicating their metallic properties. The magnetic moment calculations showed that the doping of Fe into SrCoO3 resulted in a higher net magnetic moment and all materials studied here was ferromagnetic ground states. Dielectric functions indicate the metallic conductivity for all materials studied here. The different values of the real part for materials present that this material has a Drude-like dielectric function behavior.
Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells
Authors: Nelde Annika , Schuster Heiko , Heitmann Jonas S. , Bauer Jens , Maringer Yacine , Zwick Melissa , Volkmer Jens-Peter , Chen James Y. , Stanger Anna M. Paczulla , Lehmann Ariane , Appiah Bismark , Märklin Melanie , Rücker-Braun Elke , Salih Helmut R. , Roerden Malte , Schroeder Sarah M. , Häring Max-Felix , Schlosser Andreas , Schetelig Johannes , Schmitz Marc , Boerries Melanie , Köhler Natalie , Lengerke Claudia , Majeti Ravindra , Weissman Irving L. , Rammensee Hans-Georg , Walz Juliane S. 
Published: October 2023

Abstract

Therapy-resistant leukemia stem and progenitor cells (LSC) are a main cause of acute myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of patients with AML. Here we demonstrate that LSCs present HLA-restricted antigens that induce T-cell responses allowing for immune surveillance of AML. Using a mass spectrometry–based immunopeptidomics approach, we characterized the antigenic landscape of patient LSCs and identified AML- and AML/LSC-associated HLA-presented antigens absent from normal tissues comprising nonmutated peptides, cryptic neoepitopes, and neoepitopes of common AML driver mutations of NPM1 and IDH2. Functional relevance of shared AML/LSC antigens is illustrated by presence of their cognizant memory T cells in patients. Antigen-specific T-cell recognition and HLA class II immunopeptidome diversity correlated with clinical outcome. Together, these antigens shared among AML and LSCs represent prime targets for T cell–based therapies with potential of eliminating residual LSCs in patients with AML.

Significance:
The elimination of therapy-resistant leukemia stem and progenitor cells (LSC) remains a major challenge in the treatment of AML. This study identifies and functionally validates LSC-associated HLA class I and HLA class II–presented antigens, paving the way to the development of LSC-directed T cell–based immunotherapeutic approaches for patients with AML.
See related commentary by Ritz, p. 430 .
This article is featured in Selected Articles from This Issue, p. 419
Role of Cardiac Energetics in Aortic Stenosis Disease Progression: Identifying the High-risk Metabolic Phenotype
Authors: Monga Shveta , Valkovič Ladislav , Myerson Saul G. , Neubauer Stefan , Mahmod Masliza , Rider Oliver J. 
Published: October 2023

Background:
Severe aortic stenosis (AS) is associated with left ventricular (LV) hypertrophy and cardiac metabolic alterations with evidence of steatosis and impaired myocardial energetics. Despite this common phenotype, there is an unexplained and wide individual heterogeneity in the degree of hypertrophy and progression to myocardial fibrosis and heart failure. We sought to determine whether the cardiac metabolic state may underpin this variability.

Methods:
We recruited 74 asymptomatic participants with AS and 13 healthy volunteers. Cardiac energetics were measured using phosphorus spectroscopy to define the myocardial phosphocreatine to adenosine triphosphate ratio. Myocardial lipid content was determined using proton spectroscopy. Cardiac function was assessed by cardiovascular magnetic resonance cine imaging.

Results:

Phosphocreatine/adenosine triphosphate was reduced early and significantly across the LV wall thickness quartiles (Q2, 1.50 [1.21–1.71] versus Q1, 1.64 [1.53–1.94]) with a progressive decline with increasing disease severity (Q4, 1.48 [1.18–1.70];
P
=0.02). Myocardial triglyceride content levels were overall higher in all the quartiles with a significant increase seen across the AV pressure gradient quartiles (Q2, 1.36 [0.86–1.98] versus Q1, 1.03 [0.81–1.56];
P
=0.034). While all AS groups had evidence of subclinical LV dysfunction with impaired strain parameters, impaired systolic longitudinal strain was related to the degree of energetic impairment (
r
=0.219;
P=
0.03). Phosphocreatine/adenosine triphosphate was not only an independent predictor of LV wall thickness (
r
=−0.20;
P
=0.04) but also strongly associated with myocardial fibrosis (
r
=−0.24;
P
=0.03), suggesting that metabolic changes play a role in disease progression. The metabolic and functional parameters showed comparable results when graded by clinical severity of AS.

Conclusions:
A gradient of myocardial energetic deficit and steatosis exists across the spectrum of hypertrophied AS hearts, and these metabolic changes precede irreversible LV remodeling and subclinical dysfunction. As such, cardiac metabolism may play an important and potentially causal role in disease progression.
ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by Targeting the Endo-Lysosomal Degradation of EGFR
Authors: Liu Ao , Xie Huilin , Tian Fangyan , Bai Peiyuan , Weng Haobo , Liu Yu , Liu Wen , Tang Lu , You Hongmin , Zhou Nianwei , Shu Xianhong 
Published: October 2023

BACKGROUND:
Cardiac hypertrophy and subsequent heart failure impose a considerable burden on public health worldwide. Impaired protein degradation, especially endo-lysosome-mediated degradation of membrane proteins, is associated with cardiac hypertrophy progression. CHMP4C (charged multivesicular body protein 4C), a critical constituent of multivesicular bodies, is involved in cellular trafficking and signaling. However, the specific role of CHMP4C in the progression of cardiac hypertrophy remains largely unknown.

METHODS:
Mouse models with CHMP4C knockout or cardiadc-specific overexpression were subjected to transverse aortic constriction surgery for 4 weeks. Cardiac morphology and function were assessed through histological staining and echocardiography. Confocal imaging and coimmunoprecipitation assays were performed to identify the direct target of CHMP4C. An EGFR (epidermal growth factor receptor) inhibitor was administrated to determine whether effects of CHMP4C on cardiac hypertrophy were EGFR dependent.

RESULTS:
CHMP4C was significantly upregulated in both pressure-overloaded mice and spontaneously hypertensive rats. Compared with wild-type mice, CHMP4C deficiency exacerbated transverse aortic constriction–induced cardiac hypertrophy, whereas CHMP4C overexpression in cardiomyocytes attenuated cardiac dysfunction. Mechanistically, the effect of CHMP4C on cardiac hypertrophy relied on the EGFR signaling pathway. Fluorescent staining and coimmunoprecipitation assays confirmed that CHMP4C interacts directly with EGFR and promotes lysosome-mediated degradation of activated EGFR, thus attenuating cardiac hypertrophy. Notably, an EGFR inhibitor canertinib counteracted the exacerbation of cardiac hypertrophy induced by CHMP4C knockdown in vitro and in vivo.

CONCLUSIONS:
CHMP4C represses cardiac hypertrophy by modulating lysosomal degradation of EGFR and is a potential therapeutic candidate for cardiac hypertrophy.
Arterial Stiffness Is Associated With Small Vessel Disease Irrespective of Blood Pressure in Stroke-Free Individuals
Authors: Miyagi Tomo , Ishida Akio , Shinzato Tomoko , Ohya Yusuke 
Published: October 2023

BACKGROUND:
Arterial stiffness and hypertension are important risk factors for cerebral small vessel disease (CSVD). Clinically, there are hypertensive patients with low pulse wave velocity (PWV) and nonhypertensive individuals with high PWV. We aimed to determine the effects of arterial stiffness on CSVD in normotensive individuals.

METHODS:
An observational cross-sectional study was conducted in 1894 stroke-free participants who underwent brain magnetic resonance imaging and brachial-ankle pulse wave velocity (baPWV) measurements at a health checkup between 2013 and 2020. CSVD was defined as any of following: white matter hyperintensities, cerebral microbleeds, silent lacunar infarcts, and enlarged perivascular spaces. baPWV was measured using an automatic oscillometric device. Participants were divided into 4 groups according to the following cutoff points: low blood pressure (BP, <120/80 mm Hg) with low baPWV (<14.63 m/s, a cutoff value that predicted CSVD); high BP (≥120/80 mm Hg) with low baPWV; low BP with high baPWV (≥14.63 m/s); and high BP with high baPWV.

RESULTS:
The mean age of the participants was 57±13 years (41% women). The prevalence of CSVD was 718 (38%), which was higher in the low BP with high baPWV (56%) and high BP with high baPWV (55%) groups than in the high BP with low baPWV (24%) and low BP with low baPWV (22%) groups. Compared with the low BP with low baPWV group, the low BP with high baPWV group (odds ratio, 1.63 [95% CI, 1.09–2.43]) and the high BP with high baPWV group (odds ratio, 1.86 [95% CI, 1.39–2.49]) had a significantly higher multivariable-adjusted risk for CSVD.

CONCLUSIONS:
Individuals with a high baPWV had a higher prevalence of CSVD, independent of BP status. Higher arterial stiffness is likely to be a more important risk factor for CSVD than BP status in stroke-free individuals.
Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy
Authors: Mike Jana Krystofova , White Yasmine , Hutchings Rachel S. , Vento Christian , Ha Janica , Manzoor Hadiya , Lee Donald , Losser Courtney , Arellano Kimberly , Vanhatalo Oona , Seifert Elena , Gunewardena Anya , Wen Bo , Wang Lu , Wang Aijun , Goudy Brian D. , Vali Payam , Lakshminrusimha Satyan , Gobburu Jogarao V.S. , Long-Boyle Janel , Wu Yvonne W. , Fineman Jeffrey R. , Ferriero Donna M. , Maltepe Emin 
Published: October 2023

BACKGROUND:
Hypoxic-ischemic brain injury/encephalopathy affects about 1.15 million neonates per year, 96% of whom are born in low- and middle-income countries. Therapeutic hypothermia is not effective in this setting, possibly because injury occurs significantly before birth. Here, we studied the pharmacokinetics, safety, and efficacy of perinatal azithromycin administration in near-term lambs following global ischemic injury to support earlier treatment approaches.

METHODS:
Ewes and their lambs of both sexes (n=34, 141–143 days) were randomly assigned to receive azithromycin or placebo before delivery as well as postnatally. Lambs were subjected to severe global hypoxia-ischemia utilizing an acute umbilical cord occlusion model. Outcomes were assessed over a 6-day period.

RESULTS:
While maternal azithromycin exhibited relatively low placental transfer, azithromycin-treated lambs recovered spontaneous circulation faster following the initiation of cardiopulmonary resuscitation and were extubated sooner. Additionally, peri- and postnatal azithromycin administration was well tolerated, demonstrating a 77-hour plasma elimination half-life, as well as significant accumulation in the brain and other tissues. Azithromycin administration resulted in a systemic immunomodulatory effect, demonstrated by reductions in proinflammatory IL-6 (interleukin-6) levels. Treated lambs exhibited a trend toward improved neurodevelopmental outcomes while histological analysis revealed that azithromycin supported white matter preservation and attenuated inflammation in the cingulate and parasagittal cortex.

CONCLUSIONS:
Perinatal azithromycin administration enhances neonatal resuscitation, attenuates neuroinflammation, and supports limited improvement of select histological outcomes in an ovine model of hypoxic-ischemic brain injury/encephalopathy.
Smoking Modifies the Association Between Radon Exposure and Incident Ischemic Stroke: The REGARDS Study
Authors: Zhang Yijia , Yan Qi , Angley Meghan , Lu Liping , Miller Eliza C. , Judd Suzanne E. , Field R. William , Kahe Ka 
Published: October 2023

BACKGROUND:
Exposure to radon has been linked to lung cancer and other lung diseases. Although biologically plausible, research of residential radon exposure in relation to stroke risk is scarce.

METHODS:
Study participants were from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort (n=30 239), which consisted of male and female non-Hispanic Black and White adults aged 45 and older. After excluding participants with baseline stroke and transient ischemic attack, and missing information on exposure and outcome of interest, the final sample size was 26 950. The primary outcome was time to the first ischemic stroke through September 30, 2020. County-level radon measures from Lawrence Berkeley National Laboratory were linked to each participant based on their geocoded residential history. We used Cox proportional hazards regression models with a time-dependent exposure to estimate hazard ratios and 95% CIs for the association.

RESULTS:

After controlling for potential confounding factors including demographic, lifestyle, clinical variables, and PM
2.5
, radon exposure was significantly associated with incident ischemic stroke among never-smokers (hazard ratio, 1.39 [95% CI, 1.01–1.90]) but not ever-smokers. The results were generally consistent in the sensitivity analysis when using radon measures from state/Environmental Protection Agency residential radon survey.

CONCLUSIONS:
Findings from this study suggest that the association between residential radon exposure and incidence of ischemic stroke varies by smoking status and may be prominent in never-smokers. Further studies incorporating indoor-radon measures are needed to confirm these findings.
Comparison of New Career Approach Attitudes and Subjective Career Success Perceptions in terms of Demographic Variables
Authors: ÖZTÜRK Uygar , YILDIRIM Elvan 
Published: October 2023

This study examines the impact of shifts in the structure of employment and traditional career models on perceptions of boundaryless, protean, and subjective career success among employees of private employment agencies. As private employment agencies represent a relatively new phenomenon in the modern labor market, this research aims to examine these concepts quantitatively. This research investigates the relationship between demographic characteristics and perceptions of boundaryless, protean and subjective career success among employees of private employment agencies.
The sample for this study consisted of 895 employees affiliated with private employment agencies in Istanbul. Research hypotheses were examined using exploratory factor analysis, descriptive statistics, correlation analysis, t-tests, and ANOVA. The results of this study revealed statistically significant differences in perceptions of boundaryless career attitude and subjective career success as a function of gender, age, education, marital status, and income level. However, no statistically significant differences were observed in perceptions of protean career attitudes across any demographic variable. Furthermore, the findings of this study have the potential to inform human resources, recruitment, and career planning practices.
The Politics of Youth Representation at Climate Change Conferences: Who Speaks, Who Is Spoken of, and Who Listens?
Authors: Marquardt Jens , Lövbrand Eva , Buhre Frida 
Published: October 2023

Abstract
In this article, we examine how young climate activists make use of the United Nations (UN) constituency system to give voice to children and youth in global climate governance. Our study is based on a mapping of accredited youth nongovernmental organizations (YOUNGO) as well as fieldwork at two UN Climate Change Conferences, where we conducted interviews, observed events, and analyzed plenary interventions. Informed by constructivist accounts of political representation, the article pays attention to the performative relationship between institutionalized means of youth representation and “the represented.” When analyzing our material, we asked who speaks for youth, how youth are spoken of, and how institutions shape representative speech. Our study identifies three subject positions that offer competing interpretations of who youth are as a political community and what they want. Rather than taking youth’s demands and interests as a starting point for representative politics, the article illustrates how the UN constituency system actively constructs youth and effectively molds young climate activists into professional insiders.
Tomatoes Are Red: The Perception of Achromatic Objects Elicits Retrieval of Associated Color Knowledge
Authors: Takashima Atsuko , Carota Francesca , Schoots Vincent , Redmann Alexandra , Jehee Janneke , Indefrey Peter 
Published: October 2023

AbstractWhen preparing to name an object, semantic knowledge about the object and its attributes is activated, including perceptual properties. It is unclear, however, whether semantic attribute activation contributes to lexical access or is a consequence of activating a concept irrespective of whether that concept is to be named or not. In this study, we measured neural responses using fMRI while participants named objects that are typically green or red, presented in black line drawings. Furthermore, participants underwent two other tasks with the same objects, color naming and semantic judgment, to see if the activation pattern we observe during picture naming is (a) similar to that of a task that requires accessing the color attribute and (b) distinct from that of a task that requires accessing the concept but not its name or color. We used representational similarity analysis to detect brain areas that show similar patterns within the same color category, but show different patterns across the two color categories. In all three tasks, activation in the bilateral fusiform gyri (“Human V4”) correlated with a representational model encoding the red–green distinction weighted by the importance of color feature for the different objects. This result suggests that when seeing objects whose color attribute is highly diagnostic, color knowledge about the objects is retrieved irrespective of whether the color or the object itself have to be named.
Intra- and interspecific behavioural ecology within and between Mollienesia males (sailfin molly Poecilia velifera and shortfin molly P. mexicana) in mangroves of the Yucatán peninsula
Authors: Domínguez–Castanedo Omar , Schlupp Ingo 
Published: October 2023

Abstract
Throughout their distribution range, sailfin and shortfin mollies of the genus Poecilia inhabit overlapping habitats; however, little is known about its behavioural coexistence. We first describe the ethogram of Poecilia velifera and P. mexicana in a mangrove of Yucatan. Furthermore, we identify behavioural strategies of each size morphotype/species. We describe reproductive, territorial, and cleaning behaviours in two sympatric species of mollies in their natural context, with emphasis of their behavioural interactions and coexistence. Specifically, here we document (i) specific reproductive strategies in male P. velifera morphotypes (large, intermediate-ornamented and ‘cryptic-intermediate’), suggesting that cryptic-intermediate males have advantages that suggest consequences for their reproductive success; (ii) frequent courtship and sexual behaviours from P. mexicana males directed to P. velifera females, that deserve future attention to determine the possible generation of hybrids; and (iii) increased aggressive behaviour and territoriality of P. mexicana relative to those observed in P. velifera.
Paternalism Is Not Less Wrong in Intimate Relationships
Authors: Bengtson Andreas , Midtgaard Søren Flinch 
Published: October 2023

Abstract
Many believe that paternalism is less wrong in intimate relationships. In this paper, we argue that this view cannot be justified by appeal to (i) beneficence, (ii) shared projects, (iii) vulnerability, (iv) epistemic access, (v) expressivism, or (vi) autonomy as nonalienation. We finally provide an error theory for why many may have believed that paternalism is less wrong in intimate relations.
Norwegian Internationalism and World War ii Exile Diplomacy in Print
Authors: Jakubec Pavol 
Published: October 2023

Abstract
Communication plays a vital role in diplomacy, especially in multilateral settings. Historians of World War ii diplomacy have long neglected the potential of the foreign-language print media originating with the Allied European exiles. Publicity helped the Norwegian government retain two assets of supreme importance to every exile representation – credibility and agency. Norwegian efforts in this realm manifest resourcefulness: several formats have been employed to generate visibility, reciprocity, and reputation, or to transmit positions on the international order in the making. Moreover, content analysis elucidates the transformation of Norwegian internationalism from inter-war liberal propositions towards a more “realist” understanding.
Scandinavian Diplomacy on Human Rights and Economic Inequality at the United Nations in the 1970s
Authors: Søndergaard Rasmus S. 
Published: October 2023

Abstract
In the 1970s, United Nations debates on human rights and economic inequality were deeply shaped by the New International Economic Order (nieo) advocated by the developing countries and the basic needs development strategy championed by the World Bank and the United States. This article uses archives from Sweden, Denmark, and Norway as well as UN records, to examine the contributions Scandinavian diplomats and policymakers made to these debates. It demonstrates that the Scandinavians took a favorable position on both the nieo and basic needs, viewing them as complementary strategies to realize economic and social human rights. This view matched their activist foreign policies centered on UN diplomacy, human rights, and Global South solidarity. Finally, the article argues that the Scandinavian position reflected and was underpinned by a broad conception of human rights that put economic and social rights on an even footing with civil and political rights.