bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case series of successfully managing exomphalos major with awake graduated compression dressing and early enteral feeding
Authors: Widatella Hussam , Abd Elwahab Sami , Penny Zakya , Paran Sri Thambipillai 
Published: February 2024

Abstract
Introduction
Exomphalos anomaly is defined as the herniation of abdominal viscera into the base of the umbilical cord, with only a membranous sac covering these contents. It has an incidence of approximately 1 in 4000–6000 births. Management of exomphalos major (EM) remains controversial and limited, with very few studies to guide decision-making.

Method
This is a case series of four neonates with EM treated at a tertiary paediatric referral centre between 2018 and 2021 with a gradual compression dressing technique.

Results
Four neonates were diagnosed with EM. The average gestational age was 38 + 5 (range 38 + 2 – 39 + 2), and the average birth weight was 3.1 kg (range 2.56 – 3.49 kg). The defect size ranged between 5 and 7 cm. All patients were commenced on gradual compression dressing between days 1 and 3 of life. Dressings were applied at the bedside in the general neonatal ward. The average time taken to reach full feeds was 1 week; only one patient required parenteral nutrition. Three underwent surgical repair at two and 16 weeks of age; one had delayed repair at the age of 1 year because of the COVID-19 pandemic. None required patch repair. None required prolonged ventilation after repair.

Conclusion
This case series describes a successful compression dressing technique that reduces sac content without the need for general anaesthetic or respiratory compromise, whereby simultaneous enteral feeding is tolerated.
Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study
Authors: Ibrahim Mennatullah M. , Basalious Emad B. , El-Nabarawi Mohamed A. , Makhlouf Amal IA. , Sayyed Marwa Eid , Ibrahim Ismail Taha 
Published: February 2024

AbstractMirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low bioavailability, which is only 50%, in spite of its rapid absorption when orally administered owing to high first-pass metabolism. This study was oriented towards delivering intranasal (IN) mirtazapine by a direct route to the brain by means of preparing lipid nanocapsules (LNCs) as a targeted drug delivery system. MZP-LNCs were constructed by solvent-free phase inversion temperature technique applying D-Optimal mixture design to study the impact of 3 formulation variables on the characterization of the formulated nanocapsules. Independent variables were percentage of Labrafac oil, percentage of Solutol and percentage of water. Dependent variables were particle size, polydispersity index (PDI), Zeta potential and solubilization capacity. Nanocapsules of the optimized formula loaded with MZP were of spherical shape as confirmed by transmission electron microscopy with particle diameter of 20.59 nm, zeta potential of − 5.71, PDI of 0.223 and solubilization capacity of 7.21 mg/g. The in vivo pharmacokinetic behavior of intranasal MZP-LNCs in brain and blood was correlated to MZP solution after intravenous (IV) and intranasal administration in mice. In vivo biodistribution of the drug in mice was assessed by a radiolabeling technique using radioiodinated mirtazapine (131I-MZP). Results showed that intranasal MZP-LNCs were able to deliver higher amount of MZP to the brain with less drug levels in blood when compared to the MZP solution after IV and IN administration. Moreover, the percentage of drug targeting efficiency (%DTE) of the optimized MZP-LNCs was 332.2 which indicated more effective brain targeting by the intranasal route. It also had a direct transport percentage (%DTP) of 90.68 that revealed a paramount contribution of the nose to brain pathway in the drug delivery to the brain.
Graphical Abstract
Efficacy and safety of short-term intravesical gemcitabine vs. long-term intravesical epirubicin in the treatment of moderate to high-risk non-muscle-invasive bladder cancer: a pilot study
Authors: Chen Feiran , Du Jun , Chen Xusheng , Yang Qing , Diao Lei , Yao Xin 
Published: February 2024

Abstract
Purpose
Long-term bladder instillation therapy will bring more infusion side effects and economic consumption to patients. This study aims to compare short-term gemcitabine vs. long-term epirubicin for intravesical chemotherapy in patients diagnosed with moderate- to high-risk NMIBC treated using transurethral resection of bladder tumor (TURBT).

Materials and methods
This randomized controlled trial enrolled patients diagnosed with pT1 bladder cancer who underwent TURBT at Tianjin Medical University Cancer Institute from (01/2015- 07/2018), randomized 1:1 to gemcitabine vs. epirubicin. Recurrence-free survival (RFS) and progression-free survival (PFS) were monitored by cystoscopy. Side-effects after intravesical instillation and QLQ-C30 questionnaire were collected.

Results
Finally, 208 patients were enrolled. The median follow-up was 50.6 (6–69) months. The median RFS of the gemcitabine vs. epirubicin groups were 46.7 (6–69) vs. 47.2 (8–69) months, respectively (P > 0.05); the median PFS was 51.3 (9–69) vs. 50.9 (27–69) months, respectively (P > 0.05). The incidence rates of lower urinary tract symptoms, dysuria, hypo gastralgia, and gastrointestinal symptoms in the epirubicin group were 33.3%, 6.7%, 17.7%, and 18.3%, compared with 8.5%, 3.4%, 8.5% and, 1.2%, respectively, for gemcitabine. The gemcitabine group had a better quality of life than epirubicin in global health status (82.8 ± 8.5 vs. 79.6 ± 4.2, P = 0.01) and pain symptom domain (1.1 ± 2.8 vs. 2.4 ± 3.8, P = 0.04).

Conclusions
There are no significant differences in efficacy between gemcitabine and epirubicin for intravesical chemotherapy in patients with moderate to high-risk NMIBC to prevent tumor recurrence or progression for patients intolerant to BCG or those for whom BCG is not accessible. Patients with gemcitabine suffer fewer adverse events and have a better health status than with epirubicin.
PM2.5-bound polycyclic aromatic hydrocarbons (PAHs): quantification and source prediction studies in the ambient air of automobile workshop using the molecular diagnostic ratio
Authors: Onaiwu Gregory E. , Ifijen Ikhazuagbe H. 
Published: February 2024

AbstractThe presence of polycyclic aromatic hydrocarbons (PAHs) in the atmosphere has been linked to health concerns, including cancer. Automobile workshops are significant contributors to PAH emissions due to their operations. Hence, this investigation aimed to identify and quantify the sources of PM2.5-bound PAHs in the ambient air of automobile workshops in Benin City, Nigeria, using molecular diagnostic ratios. PM2.5 samples were collected from 60 automobiles over 1 year, during the rainy (April to November) and dry (December to March) seasons of 2019. Sample collection utilized a low-volume air sampler with quartz filter paper, and extraction was performed using a 1:1 mixture of acetone and dichloromethane. The analysis involved an HP Agilent Technology 6890 Gas Chromatography (GC) system with a flame ionization detector. The annual average concentrations of PM2.5-bound PAHs in Benin City were 269.87 ± 249.32 ng/m3 (dry season) and 216.30 ± 204.89 ng/m3 (wet season). Molecular diagnostic ratios, such as Fl/(Fl + Py), An/(An + Phe), BaP/(BaP + Chry), BbF/BkF, InP/(InP + BghiP), and BaA/(BaA + Chr), aided in identifying PAH sources. Gasoline combustion, diesel combustion, traffic emissions, and emissions from automobile panel welders were found to be the primary sources of PAHs near vehicle workshops. These findings provide crucial insights for developing effective strategies to reduce emissions and protect public health in the air surrounding automobile workshops in Benin City.
A Systems-Thinking Model of Data Management and Use in US Archaeology
Authors: Bollwerk Elizabeth , Gupta Neha , Smith Jolene 
Published: February 2024

OverviewArchaeology in the United States is caught in a “curation crisis” (Childs 1995; Childs and Warner 2019; Marquardt et al. 1982; SAA Advisory Committee on Curation 2003; Trimble and Marino 2003) and a “digital data crisis” (or “deluge”) more specifically (Bevan 2015; Clarke 2015; Kansa and Kansa 2021; Katsianis et al. 2022; Kersel 2015; McManamon et al. 2017:239–240; Rivers Cofield et al. 2024). Recent estimates suggest that, collectively, over 1.4 billion dollars are spent annually to support archaeological work that is mandated by federal law (SRI Foundation 2020). Although substantial efforts are underway to generate and provide mechanisms for managing, curating, and sharing the resultant digital data, we suggest that a critical step that has yet to be taken is to describe and visualize the components, connections, and causal dynamics of the US digital data system as it currently functions. Here, we specifically apply a “systems thinking” approach to produce such a high-level model of this system. We argue that understanding and visualizing this system will help us all “think bigger” (Heilen and Manney 2023); identify sources of knowledge, opportunities for critical analysis, collaboration, and capacity building; and increase much-needed archaeological digital literacy (Kansa and Kansa 2022). We conceptualize this as bringing “equilibrium” to the system, and in this article, we make several suggestions on how to bring this about. These insights can enable practitioners to better understand their roles in and contributions to the overall system and to evaluate efforts to improve data sharing, management, and curation practices not only within their organizations and departments but beyond.
A content analysis: analyzing topics of conversation under the #sustainability hashtag on Twitter
Authors: Gerber Aydan 
Published: February 2024

Abstract
This study aimed to identify and understand the major topics of discussion under the #sustainability hashtag on Twitter (now known as “X”) and understand user engagement. The sharp increase in social media usage combined with a rise in climate anomalies in recent years makes the area of sustainability with respect to social media a critical topic. Python was used to gather Twitter posts between January 1, 2023, and March 1, 2023. User engagement metrics were analyzed using a variety of statistical analysis methods, including keyword-frequency analysis and Latent Dirichlet Allocation (LDA), which were used to identify significant topics of discussion under the #sustainability hashtag. Additionally, histograms and scatter plots were used to visualize user engagement. LDA analysis was conducted with 7 topics after trials were run with various topics and results were analyzed to determine which number of topics best fit the dataset. The frequency analysis provided a basic overview of the discourse surrounding #sustainability with the topics of technology, business and industry, environmental awareness, and discussion of the future. The LDA model provided a more comprehensive view, including additional topics such as Environmental, Social, and Governance (ESG) and infrastructure, investing, collaboration, and education. These findings have implications for researchers, businesses, organizations, and politicians seeking to align their strategies and actions with the major topics surrounding sustainability on Twitter to have a greater impact on their audience. Researchers can use the results of this study to guide further research on the topic or contextualize their study with existing literature within the field of sustainability.
Characteristics and Trends of the Campbell Plateau Meander in the Southern Ocean: 1993–2020
Authors: Liu Xinlong , Meyer Amelie , Chapman Christopher C. 
Published: February 2024

AbstractMeanders are significant features of the Antarctic Circumpolar Current in the Southern Ocean and sites of enhanced upwelling, cross‐frontal tracer fluxes, and exchanges between the surface and deep ocean. They often overlap the locations of fronts and are linked to topographic features. While much is known about Southern Ocean fronts and how they are changing, the response of meanders to climate change is largely unexplored. In this study, we investigate the Campbell Plateau meander south of New Zealand. We apply a local gradient maxima method to satellite altimetry data to identify the position of the meander and estimate its width, geostrophic current speed, and associated trends from 1993 to 2020. We find that the position of the meander has been relatively fixed, except for a section downstream of the Plateau, which has shifted northward by about 0.4° latitude per decade. The meander has become flatter at the western edge of the Plateau, but steeper at the eastern edge of the Plateau. Overall, the meander has widened by 2 km per decade and accelerated by 0.01 m s−1 per decade, particularly downstream of the Plateau. These findings are consistent with other work on standing meanders in the Southern Ocean. Increases in eddy kinetic energy and of the South Pacific Gyre index support our hypotheses that changes in the downstream jet stability and the South Pacific Gyre contribute to these observed trends. The impacts of these trends on cross‐frontal transport remain to be evaluated.
Understanding Biases in Indian Ocean Seasonal SST in CMIP6 Models
Authors: McKenna Sebastian , Santoso Agus , Sen Gupta Alex , Taschetto Andréa S. 
Published: February 2024

AbstractThe latest generation of climate models continue to exhibit biases in their representation of climatological sea surface temperature (SST), affecting their ability to simulate climate variability including the Indian Ocean Dipole which is typically too strong. Here, we analyze the surface layer heat budget of the Indian Ocean to diagnose the processes leading to biases in climatological SST biases in 20 Coupled Model Intercomparison Project Phase 6 (CMIP6) models, in comparison to a suite of observational and reanalysis products. In the western tropical Indian Ocean, we find that weaker than observed winds reduce the strength of surface currents leading to warm SST bias. In the south‐eastern tropical Indian Ocean, overly strong southeasterly winds are associated with overestimated coastal upwelling that increases cooling across CMIP6 models. In the Arabian Sea, overly strong surface winds increase latent heat loss and leads to cool SST biases. We also analyze other regions like the Bay of Bengal, where a persistent cool bias cannot be explained by seasonal heat budgets, and southern Indian Ocean, where overly strong surface winds are responsible for cool SST biases. These biases in surface processes are supported by intermodel relationships between relevant variables, thus explaining differences in simulating the climatological SSTs across the model ensemble. Our analysis suggests that biases in atmospheric processes in particular surface winds are a primary cause of biases in Indian Ocean SST. Reducing these biases would improve the simulation of climate variability in the Indian Ocean toward more reliable climate projections and predictions.
Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription
Authors: Xu Tao , Xiong Mengqiu , Hong Qiwei , Pan Bei , Xu Mu , Wang Ying , Sun Yalan , Sun Huiling , Pan Yuqin , Wang Shukui , He Bangshun 
Published: February 2024

AbstractBreast cancer (BC) is the most commonly diagnosed malignant tumour in females worldwide. Although remarkable advances in early detection and treatment strategies have led to decreased mortality, recurrence and metastasis remain the major causes of cancer death in BC patients. Increasing evidence has demonstrated that circular RNAs (circRNAs) play critical roles in cancer progression. However, the detailed biological functions and molecular mechanisms of circRNAs in BC are unclear. The aim of this study was to investigate the possible role of circRNAs in the progression of BC. Differentially expressed circRNAs in BC were identified by integrating breast tumour-associated somatic CNV data and circRNA high-throughput sequencing. Aberrant hsa_circ_0007990 expression and host gene copy number were detected in BC cell lines via quantitative polymerase chain reaction (qPCR). The expression level of hsa_circ_0007990 in BC tissues was validated by in situ hybridization (ISH). Loss- and gain-of-function experiments were performed in vitro and in vivo, respectively, to explore the potential biological function of hsa_circ_0007990 in BC. The underlying mechanisms of hsa_circ_0007990 were investigated through MS2 RNA pull-down, RNA immunoprecipitation, RNA fluorescence in situ hybridization, immunofluorescence, chromatin immunoprecipitation and luciferase reporter assays. The levels of hsa_circ_0007990 were elevated in BC tissues and cell lines, an effect that was partly due to host gene copy number gains. Functional assays showed that hsa_circ_0007990 promoted BC cell growth. Mechanistically, hsa_circ_0007990 could bind to YBX1 and inhibit its degradation by preventing ubiquitin/proteasome-dependent degradation, thus enhancing the expression of the cell cycle-associated gene E2F1. Rescue experiments suggested that hsa_circ_0007990 promoted BC progression through YBX1. In general, our study demonstrated that hsa_circ_0007990 modulates the ubiquitination and degradation of YBX1 protein and further regulates E2F1 expression to promote BC progression. We explored the possible function and molecular mechanism of hsa_circ_0007990 in BC and identified a novel candidate target for the treatment of BC.
HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia
Authors: Jing Mengjia , Xiong Xiaofeng , Mao Xin , Song Qianben , Zhang Lumiao , Ouyang Yiming , Pang Yingzhi , Fu Yu , Yan Wei 
Published: February 2024

AbstractMitochondrial transfer plays an important role in various diseases, and many mitochondrial biological functions can be regulated by HMGB1. To explore the role of mitochondrial transfer in hepatocellular carcinoma (HCC) and its relationship with HMGB1, field emission scanning electron microscopy, immunofluorescence, and flow cytometry were used to detect the mitochondrial transfer between HCC cells. We found that mitochondrial transfer between HCC cells was confirmed using tunnel nanotubes (TNTs). The transfer of mitochondria from the highly invasive HCC cells to the less invasive HCC cells could enhance the migration and invasion ability of the latter. The hypoxic conditions increased the mitochondrial transfer between HCC cells. Then the mechanism was identified using co-immunoprecipitation, luciferase reporter assay, and chromatin immunoprecipitation. We found that RHOT1, a mitochondrial transport protein, promoted mitochondrial transfer and the migration and metastasis of HCC cells during this process. Under hypoxia, HMGB1 further regulated RHOT1 expression by increasing the expression of NFYA and NFYC subunits of the NF-Y complex. RAC1, a protein associated with TNTs formation, promoted mitochondrial transfer and HCC development. Besides, HMGB1 regulated RAC1 aggregation to the cell membrane under hypoxia. Finally, the changes and significance of related molecules in clinical samples of HCC were analyzed using bioinformatics and tissue microarray analyses. We found that HCC patients with high HMGB1, RHOT1, or RAC1 expression exhibited a relatively shorter overall survival period. In conclusion, under hypoxic conditions, HMGB1 promoted mitochondrial transfer and migration and invasion of HCC cells by increasing the expression of mitochondrial transport protein RHOT1 and TNTs formation-related protein RAC1.
Psychological well-being in Europe after the outbreak of war in Ukraine
Authors: Scharbert Julian , Humberg Sarah , Kroencke Lara , Reiter Thomas , Sakel Sophia , ter Horst Julian , Utesch Katharina , Gosling Samuel D. , Harari Gabriella , Matz Sandra C. , Schoedel Ramona , Stachl Clemens , Aguilar Natalia M. A. , Amante Dayana , Aquino Sibele D. , Bastias Franco , Bornamanesh Alireza , Bracegirdle Chloe , Campos Luís A. M. , Chauvin Bruno , Coetzee Nicoleen , Dorfman Anna , dos Santos Monika , El-Haddad Rita W. , Fajkowska Malgorzata , Göncü-Köse Asli , Gnisci Augusto , Hadjisolomou Stavros , Hale William W. , Katzir Maayan , Khechuashvili Lili , Kirchner-Häusler Alexander , Kotzur Patrick F. , Kritzler Sarah , Lu Jackson G. , Machado Gustavo D. S. , Martskvishvili Khatuna , Mottola Francesca , Obschonka Martin , Paolini Stefania , Perugini Marco , Rohmer Odile , Saeedian Yasser , Sergi Ida , Shani Maor , Skimina Ewa , Smillie Luke D. , Talaifar Sanaz , Talhelm Thomas , Tokat Tülüce , Torres Ana , Torres Claudio V. , Van Assche Jasper , Wei Liuqing , Yalçın Aslı , van Zalk Maarten , Bühner Markus , Back Mitja D. 
Published: February 2024

AbstractThe Russian invasion of Ukraine on February 24, 2022, has had devastating effects on the Ukrainian population and the global economy, environment, and political order. However, little is known about the psychological states surrounding the outbreak of war, particularly the mental well-being of individuals outside Ukraine. Here, we present a longitudinal experience-sampling study of a convenience sample from 17 European countries (total participants = 1,341, total assessments = 44,894, countries with >100 participants = 5) that allows us to track well-being levels across countries during the weeks surrounding the outbreak of war. Our data show a significant decline in well-being on the day of the Russian invasion. Recovery over the following weeks was associated with an individual’s personality but was not statistically significantly associated with their age, gender, subjective social status, and political orientation. In general, well-being was lower on days when the war was more salient on social media. Our results demonstrate the need to consider the psychological implications of the Russo-Ukrainian war next to its humanitarian, economic, and ecological consequences.
Light-induced stomatal opening requires phosphorylation of the C-terminal autoinhibitory domain of plasma membrane H+-ATPase
Authors: Fuji Saashia , Yamauchi Shota , Sugiyama Naoyuki , Kohchi Takayuki , Nishihama Ryuichi , Shimazaki Ken-ichiro , Takemiya Atsushi 
Published: February 2024

AbstractPlasma membrane H+-ATPase provides the driving force for light-induced stomatal opening. However, the mechanisms underlying the regulation of its activity remain unclear. Here, we show that the phosphorylation of two Thr residues in the C-terminal autoinhibitory domain is crucial for H+-ATPase activation and stomatal opening in Arabidopsis thaliana. Using phosphoproteome analysis, we show that blue light induces the phosphorylation of Thr-881 within the C-terminal region I, in addition to penultimate Thr-948 in AUTOINHIBITED H+-ATPASE 1 (AHA1). Based on site-directed mutagenesis experiments, phosphorylation of both Thr residues is essential for H+ pumping and stomatal opening in response to blue light. Thr-948 phosphorylation is a prerequisite for Thr-881 phosphorylation by blue light. Additionally, red light-driven guard cell photosynthesis induces Thr-881 phosphorylation, possibly contributing to red light-dependent stomatal opening. Our findings provide mechanistic insights into H+-ATPase activation that exploits the ion transport across the plasma membrane and light signalling network in guard cells.