bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Creation of Human Epithelial Tissue Graft Derived From Human Blood Cord Mesenchymal Stem Cells and Human Amniotic Membrane to Be Applied in Emergency Care
Authors: Nguyen Binh Thanh , Balzanelli Mario G , Distratis Pietro , Lazzaro Rita , Nguyen Khanh Hoa , Huong Hoang KC , Tran Thuy Thi Thanh , Nhan Ngoc Hien , Nguyen Hien Thi Thu , Ngo Thai Minh Quan , Nguyen Tuan Kiet , Inchingolo Francesco , Santacroce Luigi , Dipalma Gianna , Nguyen Kieu CD , Isacco Ciro Gargiulo , Duy Thao Huynh 
Published: January 2024

Abstract

Due to its outstanding biological properties human amniotic membrane (hAM) has been a topic of medical research for many years in trying to treat, repair and regenerate difficult damages related to the epithelial surface, corneal epithelial, orthopedic, and infected body parts. The hAM’s showed also to possess crucial anti-inflammatory, anti-bacterial, and anti-viral properties and immunomodulating qualities. As a consequence, the hAM is one of the most used natural bio-materials in tissue engineering for the construction of bio-scaffolds. We used human hAM (hAM) as a raw material source to home umbilical cord mesenchymal stem cells (hUCB-MSCs) to manufacture collagen membranes that could fully meet the standards for making a skin scaffold, with suitable mechanical strength whilst limiting the risk graft rejection. Among the varieties of stem cells currently being researched MSCs are the most studied and applied due to their outstanding bio-qualities and regenerative features. We used International Society for Cells and Gene Therapy (ISCT) standards to identify and characterize the hUCB-MSCs obtained from a consent donor’s umbilical cord blood. In this study, we used hAM as a scaffold to culture domestic hUBC-MSCs to create human-like epithelial tissues aimed at repairing and regenerating the epithelial layer following trauma, deep damage from accidents, burns, and/or conditions post-operative. We used an inverted phase contrast microscope to observe the cultured growing cells on the amniotic specimens to evaluate morphological changes and epithelial stratification. Staining techniques such as H&E and Trichrome were used to evaluate the morphology and structure of the new epithelial construct, histochemical staining with p63 and ck 1/10 markers was instead used to evaluate the cellular characteristics, the transmission electron microscopy (TEM) was used to validate cell junctions. Ultimately, the results successfully showed the possibility of obtaining human-like epithelial tissue with multiple cell layers with morphology and characteristics similar to human epithelial-like tissue. The results of this study will constitute a potential alternative to autologous skin grafting in cases of heavy skin loss and deep lesions.
Does digital technology promote ecological civilization construction?Evidence from China
Authors: chang jianxin 
Published: January 2024

Abstract

With the rapid growth of digital technology, understanding its impact on ecological civilization construction (ECC) is essential. This study measures the level of digital technology and ECC in 31 provinces of China, from 2011 to 2022. Using a two-way fixed effect model, threshold effect model, and spatial spillover effect model, this study explores the impact of digital technology on ECC. The main research conclusions include: (1) Digital technology can significantly promote ECC. After robustness and endogeneity tests, this conclusion still holds. (2) Regional heterogeneity exists in the promotion effect of digital technology on ECC, manifested as western > central > eastern. (3) The promotion effect of digital technology on ECC is non-linear. When the level of digital technology exceeds a certain threshold, its promotion effect on ECC will be weakened. (4) Digital technology not only promotes ECC in the studied locality but also has a positive spatial spillover effect on ECC in adjacent geographical regions. Based on the above research conclusions, this study identifies some policy implications.
Kinetic Ferromagnetism and Topological Magnons of the Hole-Doped Kitaev Spin Liquid
Authors: Jin Hui-Ke , Kadow Wilhelm , Knap Michael , Knolle Johannes 
Published: January 2024

Abstract

We study the effect of hole doping on the Kitaev spin liquid (KSL) and find that for ferromagnetic (FM) Kitaev exchange K the system is very susceptible to the formation of a FM spin polarization. Through density matrix renormalization group (DMRG) simulations on finite systems, we uncover that the introduction of a single hole with a hopping strength of just t~0.28K is enough to disrupt fractionalization and polarize the spins in the [001] direction due to an order-by-disorder mechanism. Taking into account a material relevant FM anisotropic spin exchange KΓK drives the polarization towards the [111] direction via a reorientation transition into a topological FM state with chiral magnon excitations. We develop a parton mean-field theory incorporating fermionic holons and bosonic spinons/magnons, which accounts for the doping induced FM phases and topological magnon excitations. We discuss experimental signatures and implications for Kitaev candidate materials.
An novel effective and safe model for the diagnosis of nonalcoholic fatty liver disease in China: gene excavations, clinical validations, and mechanism elucidation
Authors: Wang Jida , Jia Beitian , Miao Jing , Li Dun , Wang Yin , Han Lu , Yuan Yin , Zhang Yuan , Wang Yiyang , Guo Liying , Jia Jianwei , Zheng Fang , Lai Sizhen , Niu Kaijun , Li Weidong , Bian Yuhong , Wang Yaogang 
Published: January 2024

Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Due to the complexity and severity, an early diagnosis is crucial to guarantee a good quality of life.
Methods
The GSE89632 dataset was downloaded from the Gene Expression Omnibus database and then screened for differential genes using different machine learning methodologies. Blood samples from 320 NAFLD patients and livers from 12 mice were collected for experimental validation.
Results
AP-1 transcriptin factor subunit (FOSB), glycerol-3-phosphate acyltransferase 3 (GPAT3), regulator of the cell cycle (RGCC), and ring finger protein 43 (RNF43) were the key diagnostic genes for NAFLD, and they were further confirmed by a receiver operating characteristic curve analysis. we found that our selected genes when combined together, exhibited a strong ability in identifying NAFLD samples from normal samples (AUC = 0.997) and experimentally examined the expression of these genes in NAFLD patients and NAFLD mice with the same results.
Conclusions
Data from both clinical and animal studies demonstrate the high sensitivity, specificity and safety of FOSB, GPAT3, RGCC and RNF43 for the diagnosis of NAFLD. The relationship between diagnostic key genes and immune cell infiltration may help to understand the development of NAFLD. The study was reviewed and approved by Ethics Committee of Tianjin Second People's Hospital in 2021 (ChiCTR1900024415).
Influence of residual strength on progressive collapse of GFRP composite panels under transverse loading
Authors: Nazari Ali Reza , Taheri Farid , Khanzadeh-Moradllo Mehdi 
Published: January 2024

Abstract

Collapse of panels under transverse loads has been reported dependent on formation of some unstable subregions surrounded by failure lines (hinges) within the panels, however such a collapse mechanism has been less investigated for the composite panels. In this paper, the significance of residual strength in the flexural failure lines around the unstable subregions through the collapse of GFRP panels was investigated. In the experimental program, the panels made of E-glass/vinylester composite laminates with various layups and aspect ratios were examined. To observe progression of failure lines in the panels due to large deflections, by application of a support composed of tubular components, the restraining influence of support on the panels was minimized. Based on well-known criteria, initiation and evolution of damage in the composite panels were simulated using the FE models. By a good estimation from the compressive residual strength in the failure lines based on the results of uniaxial compressive and three-point-bending tests, the FE models could simulate softening of the composite panels prior to collapse and temporary stability prior to complete loss of load carrying capacity. Using the FE models, contribution of various strain components in the flexural failure of the laminates and the influence of residual strength on the energy absorption capacity was probed for various configurations of the laminates.
Occupational Injuries and Infection Risk Among Senior Medical Students: A Four-Year Retrospective Study
Authors: Güllü Muhsin , Turkkan Alpaslan 
Published: January 2024

Abstract
Background
Workplaces present health and safety risks, especially for healthcare workers, such as medical students, who face a variety of hazards. Despite acquiring skills during medical school, medical faculty students, especially those engaged in patient-related practices, face increased injury risks due to factors such as lack of knowledge, insufficient practice, and high workload. This study investigated the prevalence and characteristics of occupational injuries among final-year medical students of Uludag University Faculty of Medicine.
Methods
A cross-sectional study analyzed injuries from January 1, 2019, to December 31, 2022. Data were collected from records, including demographic details, injury specifics, and students’ post-injury attitudes.
Results
In this period, 395 senior students experienced 456 injuries, with prevalence rates of 33.9%, 20.7%, 22.6%, and 30.4% from 2019 to 2022, respectively. The majority (60.7%) were female, and injuries were most common in the Emergency Department (64.9%), predominantly affecting the Hand/Finger (87.7%). Of the 395 students, three were HbsAg positive, 13 anti-HbS negative, one anti-HCV positive, and one anti-HIV positive. Considering the potential window period, only 18% of students gave control blood after 456 injuries.
Conclusion
The study focuses on the prevalence and characteristics of occupational injuries among senior medical students. The findings indicate that healthcare workers require better training, increased awareness of injury prevention, and regular screening for bloodborne diseases. Conducting blood tests after the appropriate window period is crucial to ensure early diagnosis and treatment following an injury.
Septic arthritis or adult-onset Still's disease (AOSD) - Analyzing the causes of recurrent fever after arthroscopic combined anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction: a case report and literature review
Authors: Tian Zenan , Ni Jianlong , Wei Wang , Song Qichun , Liu Shanshan , Wang Dongjian , Li Ruiying , Wang Dazhi , Chen Zhihao , Jia Zhikun , Jiang Jiajun , Shi Zhibin 
Published: January 2024

Abstract
Background
AOSD and septic arthritis share similar clinical symptoms, including recurrent fever, affected joint pain and limited mobility. This similarity poses diagnostic challenges when encountering a case of arthroscopic combined ACL and PCL reconstruction, where clinical evidence is insufficient to establish a definitive diagnosis between the two diseases. In this case, through a series of examinations and diagnostic treatment, the final diagnosis was AOSD.
Case presentation
A 41-year-old male who underwent arthroscopic combined ACL and PCL reconstruction half a month prior was admitted to our hospital with a weeklong history of recurrent fever and polyarticular pain. The positive physical signs and test results were insufficient to establish a definitive diagnosis between AOSD and septic arthritis. Therefore, a multidisciplinary team consisting of the orthopedic, infectious disease, rheumatism and immunology, hematology, respiratory, and pharmaceutical departments was formed to determine the diagnosis and establish a treatment plan. During the treatment period, the patient developed a typical rash and pharyngalgia. Multiple highly effective antibiotics were ineffective during the patient’s treatment, but the symptoms improved significantly after the administration of methylprednisolone, aspirin, and tocilizumab. The diagnosis of AOSD was ultimately determined according to the Yamaguchi criteria. After treatment, the patient's condition remained stable, and he was discharged from the hospital. During the subsequent two-month follow-up, the patient's condition remained stable without recurrence of symptoms, and the knee joint function returned to normal.
Discussion and conclusion
We could not retrieve any relevant case reports of AOSD after arthroscopic combined ACL and PCL reconstruction in several databases. Therefore, we believe this may be the first reported case. In conjunction with the relevant literature, we summarize the differences in clinical symptoms between septic arthritis and AOSD. Reviewing the patient's hospitalization process, we discuss the "controversial" diagnostic and therapeutic measures taken by the multidisciplinary team, along with any doubts and considerations. In conclusion, in cases where it is difficult to establish a definitive diagnosis between AOSD and septic arthritis, a collaborative approach involving multiple departments can be used for diagnosis and treatment, thereby shortening the diagnostic time and avoiding unnecessary diagnosis and treatment.
Intercropping Improves Tea Quantity and Quality with Enhanced Soil Nutrients, Soil Enzyme Activity, and Bacterial Community Structure
Authors: Cao Guangyun , Zhao Guoyu , Qin Jiayong , Yang Xiuju , Zhou Xia , Jin linhong 
Published: January 2024

Abstract
Background and aims
The intercropping practice has drawn more attention in tea gardens and is expected to improve soil nutrient and tea quality and change the soil microbial community composition. However, the effects of clover or peanut intercropped in the tea plant and their effect on soil nutrients and bacterial community structure of tea plantation soil and tea quality and yield are not clear. Here in this study, the soil bacterial community structure, soil nutrient and enzyme activities, tea quality and yield were investigated and compared in different planting pattern.
Methods
The bacterial diversity and community composition and their changes were evaluated by high-throughput sequencing of the V4 region of soil 16S rDNA.
Results
The soil nutrient factors, namely the soil moisture content (MC), pH, organic matter (OM), total nitrogen (TN), total phosphorus (TP), total potassium (TP), and soil peroxidase, acid phosphatase (ACP), and sucrase (SC) were found increased significantly in the intercropping pattern. The soil bacterial diversity was beneficially increased. Proteobacteria, Acidobacteria, Chloroflexi, Bacteroidota, and Gemmmatimonates were found predominant in different cropping patterns but with significantly different abundance. Mantel test correlation analysis showed that the dominant differential bacteria matrix was significantly correlated to the matrix of physicochemical factors such as MC, TN, catalase (CAT), and urease (UE) (p < 0.05). The predicted metabolic function analysis showed that carbohydrate metabolism, amino acid metabolism, biosynthesis of other secondary metabolites, and cell growth/death were the main metabolic functional pathways. Further, tea quality and yield in intercropping practices were all promoted.
Conclusion
The study indicated that these two leguminous plants had compatibility with tea plants and can benefit soil microorganisms and nutritional function hence promoting tea growth. This report provides evidence that leguminous crops are beneficial for the long-term sustainable management and efficient production of tea plantations and are of great potential to raise the incomes of tea farmers and producers.
Transcatheter arterial embolization for unilateral active adrenal hemorrhage that developed after COVID-19 infection: A case report
Authors: Suzuki Tensei , Ymaguchi Hidenori , Kojima Mitsuaki , Kariyasu Toshiya , Nakamoto Raira , Nishikawa Makiko , Machida Haruhiko , Shoko Tomohisa 
Published: January 2024

Abstract
Background: Adrenal hemorrhage is rare with only a few reports of coronavirus disease 2019 (COVID-19)-related adrenal hemorrhage. Herein, we report a case of transcatheter arterial embolization for a unilateral active adrenal hemorrhage that developed after COVID-19.
Case presentation: A 73-year-old, previously healthy man presented to our hospital with sudden right-sided abdominal pain. The patient had a past medical history of hypertension, glaucoma, and COVID-19 without other history of abdominal trauma, anticoagulant use, or neoplastic or autoimmune disease. Urgent transcatheter arterial embolization was performed for an active right adrenal hemorrhage; the middle adrenal artery was embolized with 33% n-butyl-2-cyanoacrylate to manage the extravasation. Follow-up computed tomography performed three days later showed that the hematoma had shrunk. Various tests were performed on the day after admission to determine the cause of the adrenal hemorrhage. However, no suspected causes other than Covid-19 infection, including neoplastic diseases, were identified. The general condition of the patient was good; therefore, he was discharged after only one week of hospitalization.
Conclusion: We encountered a case of unilateral adrenal hemorrhage that developed after COVID-19 infection. COVID-19 infection may cause an increased risk of bleeding or thromboembolism and the exact frequency of adrenal hemorrhage secondary to COVID-19 remains unknown; however, COVID-19 infection may cause an increased bleeding risk or thromboembolism. Hence, clinicians should be aware that adrenal hemorrhage is a possible delayed consequence of COVID-19 infection.
Comparison of laser cladding properties of tantalum and tantalum pentoxide powders on titanium substrates
Authors: Li Yi-Ju , Hsieh Yueh-Hung , Lin Wei-Ting , Tran Hong-Chuong , Huang Jun-Wei , kuo tsung yuan , Chien Chi-Sheng 
Published: January 2024

Abstract

Tantalum (Ta) has excellent mechanical properties, biocompatibility, and corrosion resistance. However, its application is limited by its high cost. Tantalum pentoxide (Ta2O5), a stable oxide of Ta, is a key role of Ta surface with excellent biological properties and corrosion resistance and has the advantage of a lower cost. In this study, Ta and Ta2O5 powders were preplaced on titanium (Ti) substrates and irradiated by a diode laser to form single-layer single-pass coatings. For comparison purposes, the scanning process was performed using a range of laser powers (1000, 1500, and 2000 W) and scanning speeds (3–5, 4.5–7.5, and 6–10 mm/s). The Ta coatings showed no surface cracking. However, spherical pores were observed near the fusion line of the coating with the substrate in some samples. The porosity increases with the decrease of laser powers and the scanning speeds. The formation of these pores was attributed mainly to the evaporation of the Ti substrate during the cladding process and the subsequent entrapment of the vapor bubbles within the coating. The Ta2O5 coatings showed almost no pores but exhibited few transverse cracks on the coating surface as a result of the thermal expansion coefficient mismatch between the ceramic coating and metallic substrate. For all of the coatings, the coating hardness was significantly higher than that of the substrate. The Ta2O5 coatings (580–700 HV) showed a higher hardness than the Ta coatings (350–400 HV). Moreover, the coating hardness remained approximately constant through the coating depth, whereas that of the Ta coatings showed a notable reduction with an increasing distance from the coating surface.
A novel nomogram for predicting successful weight loss following diet and exercise intervention in people with obesity
Authors: Yu Lei , Wang Jing , Hu Zhendong , Xu Tiancheng , Zhou Weihong 
Published: January 2024

Abstract
Purpose
Obesity is a global health challenge. However, achieving successful weight loss remains challenging. Therefore, this study aims to identify potential factors for weight loss failure by analyzing pre-weight loss data.
Methods
We utilized data encompassing records of 2577 people with obesity who visited weight management clinics from 2013 to 2022, with 1276 having at least a 3-month follow-up visit. Data preprocessing involved selecting 1276 patients with follow-up data. After dietary and exercise interventions, 580 participants achieved successful weight loss. We then divided the participants into two groups to analyze their baseline, those who lost weight and those who did not.
Results
Statistical analysis was conducted using RStudio, 13 predictor variables were identified based on LASSO and logistic regression, and age emerged as the most influential predictor. A nomogram for predicting weight loss success was then developed. The nomogram demonstrated good predictive performance (AUC = 0.807) and clinical applicability, as validated by internal validation methods. Decision curve analysis (DCA) also demonstrated the nomogram's clinical utility in predicting weight loss success.
Conclusion
We developed a nomogram prediction model for successful weight loss. The nomogram is easy to use, highly accurate, and has excellent effect discrimination and calibration capabilities.
Examining Factors Contributing to Mortality in Saudi Arabia: Proposing Effective Healthcare Management Approaches: A Descriptive Study
Authors: Aljarid Sarah , Alonazi Wadi 
Published: January 2024

Abstract
Background
Non-communicable diseases (NCDs) are a leading cause of death worldwide, and their prevalence is increasing in Saudi Arabia due to unhealthy lifestyles and longer life expectancy. This research aims to investigate the primary causes of mortality in Saudi Arabia and develop healthcare management strategies to improve mortality outcomes, reduce preventable deaths, and enhance the delivery of healthcare services.
Methods
Secondary quantitative data from local statistics perdu GASTAT and WHO is utilized to analyze mortality rates and non-communicable diseases in Saudi Arabia from 2017 to 2021. The study includes the entire Saudi Arabian population, and statistical analysis is performed using IBM SPSS Statistics version 27 and Microsoft Excel.
Results
The analysis of mortality rates in Saudi Arabia over five years reveals non-communicable diseases as the primary contributors to increased mortality. Variations in mortality rates are observed between adult females and males, with standard deviations (SD) of 3.69 for females and 3.53 for males. Ischemic Heart Disease demonstrates a higher mean mortality rate among males (133.25) compared to females (87.84), followed by Stroke, Neoplasms, Kidney diseases, and Diabetes Mellitus. The regression model highlights the significant impact of different causes of death on mortality rates, offering a robust framework for predicting these rates (p < 0.001).
Conclusion
To effectively address the leading causes of mortality, Saudi Arabia requires comprehensive policy measures to manage healthcare. These measures include public health campaigns, wellness programs, early detection initiatives, government investment in medical research, regulatory measures, and policies promoting healthy lifestyles.