bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal dose for the efficacy of asenapine in patients with schizophrenia: Real‐world data
Authors: Takekita Yoshiteru , Hiraoka Shuichi , Iwama Yasuhiro , Matsui Daisuke , Aoki Nobuatsu , Ogata Haruhiko , Funatsuki Toshiya , Shimizu Toshiyuki , Murase Yuji , Koshikawa Yosuke , Kato Masaki , Kinoshita Toshihiko 
Published: November 2023

AbstractAimsA meta‐analysis of short‐term studies revealed no significant differences between the doses of asenapine, 10 and 20 mg/day, in the acute treatment of schizophrenia. However, it should be noted that many patients from clinical practice were excluded, and the dose–response to asenapine in a real‐world setting is still unclear. Additionally, the dose–response in the maintenance phase is not clear. This study aimed to evaluate the differences in the efficacy of different asenapine doses in patients with maintenance phase of schizophrenia in a real‐world setting.MethodsThis study conducted post‐marketing surveillance of asenapine in clinical settings in Japan. It followed patients diagnosed with schizophrenia who received asenapine for the first time for a maximum of 52 weeks. These patients were divided into two categories based on their average daily asenapine dosage: ≤10 mg/day and >10 mg/day. Asenapine efficacy was assessed by adjusting for patient demographics using multivariate logistic regression analysis, employing the Clinical Global Impression‐Global Improvement (CGI‐I) scale, which has seven categories.ResultsA total of 2774 patients were included in the analysis. Of these, 1689 and 1085 patients were treated with asenapine ≤10 mg/day and >10 mg/day, respectively. The CGI‐I improvement rate was significantly higher in the asenapine >10 group (p = 0.012) after adjusting for patient background factors.ConclusionThese results suggest that asenapine doses >10 mg/day may be more effective than 10 mg/day in the treatment of schizophrenia; however, further studies are needed to confirm these findings.
Realistic simulation of GPR for landmine and IED detection including antenna models, soil dispersion and heterogeneity
Authors: Stadler Sam , Schennen Stephan , Hiller Thomas , Igel Jan 
Published: November 2023

AbstractGround‐penetrating radar is an effective tool for detecting landmines and improvised explosive devices, but its performance is strongly influenced by subsurface properties as well as the characteristics of the target. To complement or replace labour‐intensive experiments on test sites, cost‐efficient electromagnetic wave propagation simulations using the finite‐difference time‐domain method are being increasingly used. However, to obtain realistic synthetic data, accurate modelling of signal alteration caused by dispersion, scattering from soil material, target contrast, shape, and inner setup, as well as the coupling effects of the antenna to the ground is required. In this study, we present a detailed three‐dimensional model of a shielded ground‐penetrating radar antenna applied to various scenarios containing metallic and non‐metallic targets buried in different soils. The frequency‐dependent intrinsic material properties of soil samples were measured with the coaxial transmission‐line technique, while a discrete random media was used to implement the heterogeneity of a gravel based on its grain‐size distribution. Our simulations show very good agreement with experimental validation data collected under controlled conditions. We accurately reproduce the amplitude, frequency, and phase of target signals, the subsurface background noise, antenna crosstalk and associated interference with target signals, and the effect of antenna elevation. The approach allows for a systematic investigation of the effects of soil, target, and sensor properties on detection performance, providing insight into novel and complex ground‐penetrating radar scenarios and the potential for a wide range of simulation possibilities for demining with ground‐penetrating radar. These investigations have the potential to improve the safety and effectiveness of landmine and improvised explosive device detection in the future, such as building a database for training deminers or developing automatic signal pattern recognition algorithms.
Development of acrylic based antimicrobial water‐based ink using curcumin for active packaging applications
Authors: Sharma Harish , Sharma Bhavna , Raghuvanshi Sharad , Kadam Ashish , Kulshreshtha Anurag , Dutt Dharm 
Published: November 2023

AbstractThis experiment was conducted to formulate a water‐based ink with antimicrobial properties for packaging applications. Two distinct types of inks were developed, one with synthetic yellow color pigment and the other with curcumin, as an antimicrobial and a natural yellow pigment. The resulting two inks were then printed on polyethylene terephthalate (PET) films, and the physiochemical characteristics of the ink were thoroughly examined. The coated inks had an average thickness of 10 microns for both the inks. The viscosity of the water‐based ink and the antimicrobial water‐based ink were determined to be 54cp and 30cp, respectively and the drying time of the inks was 10 sec. At the same time, the gloss value increased from 30% to 50% in the case of antimicrobial ink. The antimicrobial efficacy of the antimicrobial water‐based ink, as demonstrated against S. aureus and E. coli, surpassed that of the conventional water‐based ink. These findings showed that the antimicrobial water‐based ink had a good drying time, increased gloss, and favorable storage stability. Using curcumin as a pigment in water‐based ink may be significant for printing applications of active food packaging materials. It can also help lower the risk of contamination of the food components with microbes.Highlights
Synthesis of antimicrobial water‐based ink
Active packaging printing
Curcumin as an antimicrobial
Curcumin used as a natural color pigment in the ink
Acrylic resin synthesis
Anticipatory anxiety and participation in cancer screening. A systematic review
Authors: Goodwin Belinda , Anderson Laura , Collins Katelyn , Sanjida Saira , Riba Marcos , Singh Gursharan K. , Campbell Kimberley M. , Green Heather , Ishaque Sana , Kwok Alastair , Opozda Melissa J. , Pearn Amy , Shaw Joanne , Sansom‐Daly Ursula M. , Tsirgiotis Joanna M. , Janda Monika , Grech Lisa 
Published: November 2023

AbstractObjectivesTo synthesize current evidence on the association between anticipatory anxiety, defined as apprehension‐specific negative affect that may be experienced when exposed to potential threat or uncertainty, and cancer screening to better inform strategies to maximize participation rates.MethodsSearches related to cancer screening and anxiety were conducted in seven electronic databases (APA PsycINFO, Scopus, Web of Science, Embase, Cochrane Library, PubMed, CINAHL), with potentially eligible papers screened in Covidence. Data extraction was conducted independently by multiple authors. Barriers to cancer screening for any type of cancer and relationships tested between anticipatory anxiety and cancer screening and intention were categorized and compared according to the form and target of anxiety and cancer types.ResultsA total of 74 articles (nparticipants = 119,990) were included, reporting 103 relationships tested between anticipatory anxiety and cancer screening and 13 instances where anticipatory anxiety was reported as a barrier to screening. Anticipatory anxiety related to a possible cancer diagnosis was often associated with increased screening, while general anxiety showed no consistent relationship. Negative relationships were often found between anxiety about the screening procedure and cancer screening.ConclusionAnticipatory anxiety about a cancer diagnosis may promote screening participation, whereas a fear of the screening procedure could be a barrier. Public health messaging and primary prevention practitioners should acknowledge the appropriate risk of cancer, while engendering screening confidence and highlighting the safety and comfort of screening tests.
Development of Halogen‐Free Flame Retardant Acrylonitrile Butadiene Styrene (ABS) Based Composite Materials
Authors: Yildiz Cansu , Seki Yoldaş , Kizilkan Elif , Sarikanat Mehmet , Altay Lutfiye 
Published: November 2023

AbstractNatural flammability properties of acrylonitrile butadiene styrene (ABS) seriously limit the use of ABS polymers in industries. Improving the flammability performance of ABS by using halogenated additives has been a very common method in the past. However, with increasing environmental awareness, the use of halogen‐containing additives has been severely limited over time. Therefore, we aimed to use halogen‐free flame‐retardant additives in our study to improve the flame‐retardant properties of ABS. ABS‐based composites containing 20, 25, 30 % aluminum diethyl‐phosphinate (AlPi) and ammonium polyphosphate (APP) halogen‐free flame‐retardant additives by weight, were prepared using a twin‐screw extruder. V0 rating according to UL 94 standard for the thickness of 1.5 mm, limiting oxygen index (LOI) value higher than 28 %, and glow wire flammability index of 960 °C were aimed in this study. To improve the LOI values of flame‐retardant ABS composites, pentaerythritol (PER), zinc borate (ZB), and magnesium hydroxide were used. The highest LOI value was obtained to be 28.1 % by using 12.5 wt.% AlPi, 12.5 wt.% APP, 5 wt.% PER and 3 wt.% ZB. The effect of flame retardants on mechanical properties (flexural and tensile properties), impact properties (Izod and Charpy‐notched impact strength), thermal properties, melt flow index, and morphology (scanning electron microscopy) of ABS were also examined.
Combustion Synthesis of Porous NiCuZn Spinel Ferrite Hierarchies and Their Magnetic Properties
Authors: Chen Chuan , Qian Sen , Zhang Qiang , Zhang Ximin , Yao Tianhao 
Published: November 2023

AbstractNickel‐copper‐zinc (NiCuZn) spinel ferrites have attracted intensive research owing to their unique magnetic properties and low co‐fire temperature. Combustion synthesis has been viewed as a promising protocol for the large‐scale fabrication of NiCuZn spinel ferrites. However, the spinel ferrites prepared by this method usually suffer from limited saturation magnetization and high coercivity due to their large size, which will impose detrimental harmonics on electrical equipment (e. g., transformer, motor, etc.). To address these issues, highly porous NiCuZn spinel ferrite hierarchies were prepared within several hours through a modified solution combustion method, using glucose and ammonium nitrate as the fuel and combustion enhancer, respectively. The as‐obtained NiCuZn spinel ferrite hierarchies show excellent magnetic properties with a high saturation magnetization up to 62.61 emu/g and a low coercivity of 9.6 Oe thanks to the rational distribution of cations and grain size. More importantly, this method also allows various modifications (heteroatom doping) and large‐scale applications, which may be promising for the fabrication of high‐performance soft magnets for electrical equipment.
Design, Synthesis, and Anticancer Evaluation of Hemithioindigos via Inhibition of Human Topoisomerases
Authors: Kaur Manpreet , Suman Prabhat , Arora Sahil , Singh Tashvinder , Munshi Anjana , Singh Sandeep , Kumar Raj 
Published: November 2023

AbstractHemithioindigos were designed as topoisomerase inhibitors, synthesized, and evaluated for their anticancer properties against lung (A549) and breast (MDA‐MB‐468 and MCF7) cancer cell lines. Among all the synthetics, three compounds exerted potential anticancer effects on A549 (lung) and MCF7 (breast) cancer cell lines at low micromolar concentrations. The results revealed that two of these compounds blocked the cancer cells at the G1/S phase, while the third compound showed moderate G2/M inhibition, leading to necrotic cell death. Finally, the topoisomerase inhibition assays revealed their potent Topo I/II inhibitory actions as one of the primary anticancer mechanisms. Molecular docking studies further corroborated these findings.
Cobalt‐Doping Induced Formation of Five‐Coordinated Nickel Selenide for Enhanced Ethanol Assisted Overall Water Splitting
Authors: Xu Jinchang , Ruan Jiaxi , Jian Yongqi , Lao Jiayu , Li Zilong , Xie Fangyan , Jin Yanshuo , Yu Xiang , Lee Ming‐Hsien , Wang Zhenyou , Wang Nan , Meng Hui 
Published: November 2023

AbstractTo overcome the low efficiency of overall water splitting, highly effective and stable catalysts are in urgent need, especially for the anode oxygen evolution reaction (OER). In this case, nickel selenides appear as good candidates to catalyze OER and other substitutable anodic reactions due to their high electronic conductivity and easily tunable electronic structure to meet the optimized adsorption ability. Herein, an interesting phase transition from the hexagonal phase of NiSe (H‐NiSe) to the rhombohedral phase of NiSe (R‐NiSe) induced by the doping of cobalt atoms is reported. The five‐coordinated R‐NiSe is found to grow adjacent to the six‐coordinated H‐NiSe, resulting in the formation of the H‐NiSe/R‐NiSe heterostructure. Further characterizations and calculations prove the reduced splitting energy for R‐NiSe and thus the less occupancy in the t2g orbits, which can facilitate the electron transfer process. As a result, the Co2‐NiSe/NF shows a satisfying catalytic performance toward OER, hydrogen evolution reaction, and (hybrid) overall water splitting. This work proves that trace amounts of Co doping can induce the phase transition from H‐NiSe to R‐NiSe. The formation of less‐coordinated species can reduce the t2g occupancy and thus enhance the catalytic performance, which might guide rational material design.
NiCo‐LDH Hollow Nanocage Oxygen Evolution Reaction Promotes Luminol Electrochemiluminescence
Authors: Liang Wenjin , Wang Min , Ma Chaoyun , Wang Jiawen , Zhao Chulei , Hong Chenglin 
Published: November 2023

AbstractConventional luminol co‐reactant electrochemiluminescence (ECL) systems suffer from low stability and accuracy due to factors such as the ease of decomposition of hydrogen peroxide and inefficient generation of reactive oxygen species (ROS) from dissolved oxygen. Inspired by the luminol ECL mechanism mediated by oxygen evolution reaction (OER), the nickel‐cobalt layered double hydroxide (NiCo‐LDH) hollow nanocages with hollow structure and defect state are used as co‐reaction promoters to enhance the ECL emission from the luminol‐H2O system. Thanks to the hollow structure and defect state, NiCo‐LDH hollow nanocages show excellent OER catalytic activity, which can stabilize and efficiently produce ROS and enhance the ECL emission. Additionally, mechanistic exploration suggests that the ROS involved in the co‐reaction of the luminol‐H2O system are derived from the OER reaction process, and there is a positive correlation between ECL intensity and the OER catalytic activity of the co‐reaction promoter. The selection of catalysts with excellent OER catalytic activity is a key factor in improving ECL emission. Finally, a dual‐mode immunosensor is constructed for the detection and analysis of alpha‐fetoprotein (AFP) based on the promoting effect of NiCo‐LDH hollow nanocages on the luminol‐H2O ECL system.
Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25
Authors: Qin Hai , Yuan Yaqin , Yuan Manqin , Wang Haiyan , Yang Yonghong 
Published: November 2023

AbstractAlpha‐2‐glycoprotein 1, zinc‐binding (AZGP1) is a secreted protein, which has been shown to be a potential biomarker of cancer progression; however, its roles in breast cancer are still unclear. Currently, we analyzed the online datasets and found that AZGP1 was highly expressed in breast cancer tissues and its expression was negatively correlated with the survival of breast cancer patients. Functional experiments through AZGP1 knockdown revealed that AZGP1 could promote the proliferation, migration, and invasion ability of breast cancer cells. In vivo experiments obtained a consistent result. Mechanistically, it was found that AZGP1 interacted with tripartite motif‐containing protein 25 (TRIM25), which subsequently promoted AZGP1 degradation through facilitating the ubiquitination. Furthermore, overexpression of TRIM25 partially reversed the promoting effects of AZGP1 overexpression on breast cancer progression. Therefore, this study indicates that AZGP1 might be a potential therapeutic target for breast cancer treatment.
Strain diversity in Saccharomyces cerevisiae thiamine production capacity
Authors: Rocchi Rebecca , Wolkers‐Rooijackers Judith C. M. , Liao Zhuotong , Tempelaars Marcel H. , Smid Eddy J. 
Published: November 2023

AbstractVitamin B1, also known as thiamine, is an important vitamin that, besides its role in human health, is converted to meat aromas upon exposure to high temperatures. Therefore, it is relevant for the production of vegan meat‐like flavours. In this study, we investigated 48 Saccharomyces cerevisiae strains for their thiamine production capacity by measuring the intracellular and extracellular vitamins produced in the thiamine‐free minimal medium after 72 h of growth. We found approximately an 8.2‐fold difference in overall thiamine yield between the highest and lowest‐producing strains. While the highest thiamine yield was 254.6 nmol/L, the highest thiamine‐specific productivity was 160.9 nmol/g DW. To assess whether extracellular thiamine was due to leakage caused by cell damage, we monitored membrane permeabilization using propidium iodide (PI) staining and flow cytometry. We found a good correlation between the percentage of extracellular thiamine and PI‐stained cells (Spearman's ρ = 0.85). Finally, we compared S. cerevisiae CEN.PK113‐7D (wild type [WT]) to three strains evolved in a thiamine‐free medium for their thiamine production capacity. On average, we saw an increase in the amount of thiamine produced. One of the evolved strains had a 49% increase in intracellular thiamine‐specific productivity and a biomass increase of 20% compared with the WT. This led to a total increase in thiamine yield of 60% in this strain, reaching 208 nmol/L. This study demonstrated that it is possible to achieve thiamine overproduction in S. cerevisiae via strain selection and adaptive laboratory evolution.
GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma
Authors: Qin Lijuan , Wang Jiuru , Cheng Fang , Cheng Jiamin , Zhang Han , Zheng Huaguo , Liu Yongai , Liang Zhentao , Wang Baifeng , Li Changfei , Wang Haoyu , Ju Ying , Tian Huaqin , Meng Songdong 
Published: November 2023

AbstractThe placenta and tumors can exhibit a shared expression profile of proto-oncogenes. The basis of placenta-derived heat shock protein gp96, which induces prophylactic and therapeutic T cell responses against cancer including hepatocellular carcinoma (HCC), remains unknown. Here, we identified the associated long peptides from human placental gp96 using matrix-assisted laser desorption/ionization-time-of-flight and mass spectrometry and analyzed the achieved proteins through disease enrichment analysis. We found that placental gp96 binds to numerous peptides derived from 73 proteins that could be enriched in multiple cancer types. Epitope-harboring peptides from glypican 3 (GPC3) and paternally expressed gene 10 (PEG10) were the major antigens mediating anti-HCC T cell immunity. Molecular docking analysis showed that the GPC3- and PEG10-derived peptides, mainly obtained from the cytotrophoblast layer of the mature placenta, bind to the lumenal channel and client-bound domain of the gp96 dimer. Immunization with bone marrow-derived dendritic cells pulsed with recombinant gp96-GPC3 or recombinant gp96-PEG10 peptide complex induced specific T cell responses, and T cell transfusion led to pronounced growth inhibition of HCC tumors in nude mice. We demonstrated that the chaperone gp96 can capture antigenic peptides as an efficient approach for defining tumor rejection oncoantigens in the placenta and provide a basis for developing GPC3 and PEG10 peptide-based vaccines against HCC. This study provides insight into the underlying mechanism of the antitumor response mediated by embryonic antigens from fetal tissues, and this will incite more studies to identify potential tumor rejection antigens from placenta.
Aspirational family language policy
Authors: Seals Corinne A. , Beliaeva Natalia 
Published: November 2023

AbstractThe current article applies interactional sociolinguistic discourse analysis to interviews with three parents of Ukrainian families living in New Zealand to further complexify what we know about Family Language Policy (FLP) and language transmission. More specifically, this article theorizes what we call “Aspirational FLP”—when the desired imagined language identities of family members will require families to adopt an FLP that goes above and beyond what might otherwise be considered practical. In the case of our participants, this involves Ukrainians living in the diaspora who discuss the homeland’s “changing your mother tongue” discourse (from Russian to Ukrainian) and what this means when it involves replacing one heritage language with another when both are minority languages in the hostland. Additionally, we consider the importance of both homeland and hostland sociopolitical contexts, as the interviews reflect dominant discourses from both. Finally, our interview data occurs twice with the same participants (2014 and again in 2021), therein allowing us to investigate the participants’ Aspirational FLPs diachronically, bringing further insight to the dynamism of FLP. Our findings show that participants’ Aspirational FLPs are connected to both homeland and hostland sociopolitical contexts, and as such are dynamic and shifting. Aspirational FLPs also shift differently as individual family members’ investments and imagined future identities also shift. Furthermore, the longitudinal nature of the data sheds light on how and why Aspirational FLPs become reality for some families while they remain aspirational for others. We conclude that both local contexts and wider world contexts are important to consider when investigating FLP, and diachronic research is highly valuable for uncovering factors that contribute to the complexity of FLP, both Aspirational and realized.
Introduction to special issue on facilitating self-regulated learning with scaffolds: Recent advances and future directions
Authors: van der Graaf Joep , Taub Michelle , Fan Yizhou 
Published: November 2023

AbstractIt is important for learners to engage in self-regulated learning (SRL), as it predicts academic achievement in a wide range of disciplines. However, SRL can be difficult to enact. Therefore, scaffolds have been designed to support SRL. In our introductory article to this special issue on facilitating SRL with scaffolds, we present a framework to categorize different scaffolds, place the contributions to this special issue in the framework, present highlights from the contributions, and conclude with a discussion on designing scaffolds to facilitate SRL.
Wenn mehr Ganzheit gefordert wird – Agile Teams und ihre Personen
Authors: Csar Matthias , Bachmann Thomas , Bravo Katherina , Heemann Carolin 
Published: November 2023

ZusammenfassungDieser Artikel für die Zeitschrift Gruppe Interaktion Organisation (GIO) beleuchtet zunächst den theoretischen Diskurs zum Wechselspiel zwischen Person und Rolle und dessen Bedeutung für Teamarbeit. Darauffolgend wird auf Persönlichkeitseigenschaften eingegangen, die in der Entwicklung und Zusammenarbeit in agilen Teams eine Rolle spielen. Die These dabei lautet, dass narzisstische Persönlichkeitsanteile die Teamarbeit erschweren, diese in agilen Teams jedoch durch die Erwartung an mehr (persönlicher) Beteiligung zusätzlich induziert werden könnten. Aufbauend auf verschiedenen Studien zum Thema werden anschließend Ergebnisse einer explorativen Datenanalyse aus einem eigenen Forschungsprojekt zur Performance agil arbeitender Teams vorgestellt, welche zeigen, dass sich eine zu starke Personenfokussierung negativ auf die Teamleistung auswirkt.