bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research trends in readiness for hospital discharge between 2002 and 2021: A bibliometric analysis
Authors: Zhang Rong , Wang Dongmei , Zhu Ling , He Yongdong , Cheng Ling , Ma Jifen , Zhang Ting , Zhang Jun , Li Longti 
Published: September 2023

AbstractAimThis study aimed to undertake a bibliometric analysis to provide comprehensive information in demonstrating the current status and outline the overall trends in the area of readiness for hospital discharge (RHD).DesignA bibliometric and visual analysis of RHD literature was undertaken.MethodsArticles were retrieved from the Web of Science network from 2002 to 2021. VOSviewer was used to identify the co‐authorship network of countries/institutions, co‐authorship and co‐citation analysis of authors, and co‐citation analysis of references and citation analysis of documents. CiteSpace was used to identify the keyword co‐occurrence network and perform cluster analysis, detecting the keywords with citation bursts and speculated frontiers in this research field.ResultsA total of 512 articles were included in the final analysis. Key findings are: (1) There has been a continuous but somewhat fluctuating rise in the number of publications. (2) 56.05% of publications come from the USA with Marquette University making the highest contribution. (3) Most publications (17, 3.32%) in RHD research were from the Journal of Clinical Nursing, and Anaesthesia and Analgesia had the highest number of citations (584 citations). (4) Weiss ME (25, 4.88%) was the most productive author whose articles have been the most highly cited (646 citations). (5) Cited references from Weiss ME (2007) also made the largest contribution to co‐citations, and the most cited reference was from Jack BW (2009) (1022 citations). (6) The 20 most frequent keywords and keywords with the strongest citation bursts were retrieved. There were seven research hotspots, and three emerging research frontiers were explored.ConclusionsThe bibliometric analysis of material published in the last 20 years indicates that there have been statistically significant gains in comprehensive information on RHD, including the knowledge mapping of the countries, institutions, authors, references and keywords. The hotspots and frontiers, which have been explored can give guidance to researchers as to new angles and directions to take.Implications for Nursing Management

The effects of the implementation of ERAS on RHD‐related risk for adverse post‐discharge outcomes in surgical patients will be of increasing concern for healthcare professionals.

It is important for patients and their relatives to be confident that on discharge they are sufficiently ready for hospital discharge to enable them to safely and smoothly make the transition to home.

Improving the level of RHD in discharged patients can help nurse managers and researchers measure the effectiveness of discharge planning services.
Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)
Authors: Hsiao Wendy , Li Yimei , Getz Kelly , Cao Lusha , Krause Edward , Ramos Mark , Lee Judy , Gramatges Maria Monica , Rabin Karen R. , Scheurer Michael E. , Aplenc Richard , Denburg Michelle , Miller Tamara P. 
Published: September 2023

AbstractChildren with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.
Preparation of a composite of polyacrylate and nano‐SiO2 particles and evaluation of its performance of oil–water mixture treatment
Authors: Zhou Yanjia , Li Feng , Lan Guihong , Liu Yongqiang , Qiu Haiyan , Xu Bo , Pu Keyu , Dai Wenren , Zhang Xinyang 
Published: September 2023

AbstractTo acquire a material with simultaneous oil–water emulsion demulsification and oil‐absorbing performance, SiO2 nanoparticles were introduced into the acrylate polymerization system to prepare oil absorbent SiO2/P (SMA‐co‐MMA‐co‐BA) (PSA‐SiO2). PSA‐SiO2 was synthesized from monomers and functional materials, including methyl methacrylate (MMA), butyl acrylate (BA), octadecyl methacrylate (SMA) and SiO2 hydrophobically modified by vinyltrimethoxysilane. The molecular structure of PSA‐SiO2 was characterized by FT‐IR, and its morphology was observed using scanning electron microscopy. In addition, the optimal synthesis conditions for the polymerization system, such as the monomer ratio, the amount of crosslinker and stabilizer and then the particle size and dose of SiO2, were discussed in detail. PSA‐SiO2 had a decent oil absorbency for pure halogenated and aromatic hydrocarbons (49.10, 56.41, 47.32, 43.45, 36.22, and 30.14 g/g for CH2Cl2, CHCl3, CCl4, C2Cl4, toluene and styrene, respectively). Furthermore, SiO2, as a functional material, makes composites that possess excellent demulsification properties for oil‐in‐water emulsions. The oil removal efficiency of CHCl3 in Tween 80‐stabilized and CTAB‐stabilized emulsions were 94.88% and 98.11%, respectively. All results indicated that PSA‐SiO2 had valuable potential for oil removal and emulsion treatment.Highlights
An organic–inorganic composite was synthesized by suspension polymerization.
The composite was applied for absorbing pure oil or removing oil form water.
By modification, the composite acquired the demulsification ability.
The composite accomplished one‐step demulsification and emulsion treatment.
The oil absorption and emulsion treatment could achieve at room temperature.
Prenatal diagnosis of hypoplastic left heart syndrome on ultrasound using artificial intelligence: How does performance compare to a current screening programme?
Authors: Day Thomas G. , Budd Samuel , Tan Jeremy , Matthew Jacqueline , Skelton Emily , Jowett Victoria , Lloyd David , Gomez Alberto , Hajnal Jo V. , Razavi Reza , Kainz Bernhard , Simpson John M. 
Published: September 2023

AbstractBackgroundArtificial intelligence (AI) has the potential to improve prenatal detection of congenital heart disease. We analysed the performance of the current national screening programme in detecting hypoplastic left heart syndrome (HLHS) to compare with our own AI model.MethodsCurrent screening programme performance was calculated from local and national sources. AI models were trained using four‐chamber ultrasound views of the fetal heart, using a ResNet classifier.ResultsEstimated current fetal screening programme sensitivity and specificity for HLHS were 94.3% and 99.985%, respectively. Depending on calibration, AI models to detect HLHS were either highly sensitive (sensitivity 100%, specificity 94.0%) or highly specific (sensitivity 93.3%, specificity 100%). Our analysis suggests that our highly sensitive model would generate 45,134 screen positive results for a gain of 14 additional HLHS cases. Our highly specific model would be associated with two fewer detected HLHS cases, and 118 fewer false positives.ConclusionIf used independently, our AI model performance is slightly worse than the performance level of the current screening programme in detecting HLHS, and this performance is likely to deteriorate further when used prospectively. This demonstrates that collaboration between humans and AI will be key for effective future clinical use.
4‐Vinylpyridine derived physically crosslinked hydrogel as efficient mercury indicator
Authors: Kumar Rajan , Davis Elizabathe , Kalita Nripankar , Choudhury Diganta , Shunmugam Raja 
Published: September 2023

AbstractHere, we report a photoclicked crystalline monomer DiPy which forms polymeric hydrogel Polym‐DiPyC3. The monomer DiPy and polymer Polym‐DiPyC3 are well characterized using spectroscopic and analytical techniques. The rheometric curve revealed the hydrogel Polym‐DiPyC3 to exhibit viscoelasticity with a damping factor (tanδ) in the range between 0 and 1. The considered hydrogel film on exposure to mercury concentration ≥2 ppm showed a loss of transparency and swellability. Energy dispersive x‐ray and mapping confirmed the mercury presence on the surface of Polym‐DiPyC3. The material behaves as a naked‐eye indicator due to gain in opacity and loss of swellability. The DFT parameter supported the soft Lewis acid Hg2+ to guest onto the soft thioether site of the polymer film Polym‐DiPyC3.Highlights
The monomer DiPy was synthesized via thiol‐alkene photoclick reaction.
The ionic polymer Polym‐DiPyC3 is physically crosslinked.
The polymer Polym‐DiPyC3 exhibits viscoelastic property.
The mercury presence causes Polym‐DiPyC3 to lose its hydrogel property.
The observed affinity of mercury for sulfur was well supported with DFT.
Synthesis and applications of a Y‐inimer with two orthogonal controlled free radical polymerization initiators
Authors: Chen Ri , Smith Julia D. , Osores Nicolas Noriega , Gopalan Padma 
Published: September 2023

AbstractWe report the synthesis of a Y‐shaped inimer that contains two orthogonal initiators for ATRP and NMP. The inimer is synthesized through a one‐pot multi‐component reaction that vastly simplifies the typically cumbersome synthesis of similar compounds. The Y‐inimer has the versatility to be homopolymerized into a backbone for A/B Janus bottlebrush synthesis or copolymerized with glycidyl methacrylate (GMA) and cross‐linked into an ultra‐thin coating for mixed A/B brush growth from planar surfaces. Importantly, the Y‐shaped nature of the inimer ensures growth of A and B brushes are consistently in a 1:1 ratio. We demonstrate the application of the Y‐inimer in the synthesis of a PMMA/PS Janus bottlebrush as well as two different mixed A/B polymer brushes, one with the ability to microphase separate, and a second mixed polyelectrolyte brush with opposite charges. The inimer is compatible with various A/B monomer systems and offers a universal approach to the “grafting‐from” polymerization of dual vinyl polymer side chains. This study provides a unique way of utilizing multi‐component reactions in polymer chemistry to access complex functional architectures.
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14C] encorafenib in healthy male subjects
Authors: Wollenberg Lance , Hahn Erik , Williams Jason , Litwiler Kevin 
Published: September 2023

AbstractEncorafenib is a novel kinase inhibitor of BRAF V600E as well as wild‐type BRAF and CRAF and has received approval, in combination with binimetinib, to treat BRAF V600E or V600K mutation‐positive unresectable or metastatic melanoma or in combination with cetuximab to treat BRAF V600E mutation‐positive colorectal cancer. The absorption, distribution, metabolism and excretion (ADME) of encorafenib was studied by administering [14C] encorafenib (100 mg containing 90 μCi of radiolabeled material) to 4 healthy male subjects (NCT01436656). Following a single oral 100‐mg dose of [14C] encorafenib to healthy male subjects, the overall recovery of radioactivity in the excreta was ≥93.9% in all four subjects, indicating that good mass balance was achieved. An equal mean of 47.2% for the radioactivity dose was eliminated in the feces and urine. The percentage of the dose eliminated in the feces (5.0%) and urine (1.8%) as unchanged encorafenib was minor. Metabolism was found to be the major clearance pathway (~88% of the recovered radioactive dose) for encorafenib in humans and is predominantly mediated through N‐dealkylation of the isopropyl carbamic acid methyl ester to form the primary phase 1 direct metabolite M42.5 (LHY746). Oral absorption was estimated from the radioactive dose recovered in the urine (47.2%) and the total radioactive dose recovered in the feces as metabolites (39%). Based on these values and the assumptions that encorafenib and its metabolites are stable in feces, the fraction of oral absorption was estimated to be at least ~86%.
Spinal tuberculosis in Afghanistan: A 2019‐2020 study of patients in Kabul hospitals
Authors: Qaderi Farah , Mashid Idriss , Gachkar Latif , Martellucci Mosè , Qaderi Shohra , Ozaki Akihiko , Haghbin Toutounchi Alireza , Taheriazam Afshin , Asakura Takanori , Gholipoor Talemi Hojat , Mohammady Noria , Shabani Minoosh 
Published: September 2023

AbstractBackgroundTuberculosis (TB) is endemic in many low‐income countries, which can affect the spine in 1%–5% of those with an active infection. This study reports the clinical characteristics of patients admitted for spinal TB in Kabul, Afghanistan, a country with very limited resources.MethodsThis was a descriptive study among 26 patients treated for spinal TB in three major referral hospitals in Kabul, Afghanistan, between March 2019 and April 2020. The sociodemographic and clinical details, gender, age, site of infection, presenting complaints, signs, and symptoms of the patients were retrieved from their medical records. Summary statistics were analyzed using SPSS version 20. Ethics approval was obtained from the ethics committee of Shahid Beheshti University of Medical Sciences in Tehran, Iran.ResultsData were available for 26 patients with spinal TB admitted consecutively. The mean age of the sample was 38.2 years (SD 17.5), and there were 16 males and 10 females. Median time from symptom onset to hospital admission was 60 days. The most common diagnostic imaging technique used was magnetic resonance imaging (92.3%), followed by computed tomography (7.7%). The majority of the lesions involved the lumbar spine (61.4%), followed by the thoracolumbar spine (30.8%). Back pain was the most common manifestation in 21 patients (80.8%), and varying degrees of neurological impairment were found in 16 (61.5%) patients. There were no deaths among the patients up to the discharge date.ConclusionsThis study describes the clinical characteristics of spinal TB among patients in Kabul, Afghanistan. It is essential to strengthen preventive strategies and to improve health awareness about clinical features of spinal TB in patients with chronic back pain even in the absence of signs of TB.
Quantum Entanglement Protection by Utilizing Classical Noises
Authors: Zheng Wenjie , Huang Bi‐Hua , Zhao Xinyu , Xia Yan 
Published: September 2023

AbstractNoise is often considered as the biggest enemy of maintaining quantum entanglement. However, in this paper, it shows quantum entanglement can be protected by introducing extra noises to a quantum system. As an example, the dynamics of a two‐qubit system coupled to a cavity is studied under the influence of three noises, a quantized noise from the leakage of the cavity and two classical noises in the couplings between the two‐qubit system and the cavity. The master equation beyond the Markov approximation is derived and the mechanism of the entanglement protection is analyzed in a special case with analytical solutions. In short, the entanglement loss caused by the dissipation to the bath might be weaken by introducing high‐frequency classical noises properly. The numerical simulations not only confirm the feasibility of protecting entanglement by noises but also reveal that the properties of the classical noises have a significant impact on the performance of the entanglement protection.
High‐Resolution Single Photon Level Storage of Telecom Light Based on Thin Film Lithium Niobate Photonics
Authors: Ekici Çağın , Yu Yonghe , Adcock Jeremy C. , Muthali Alif Laila , Tan Heyun , Lin Zhongjin , Li Hao , Oxenløwe Leif Katsuo , Cai Xinlun , Ding Yunhong 
Published: September 2023

AbstractThis study presents an experimental analysis of high‐resolution single photon buffers based on low‐loss thin film lithium niobate (TFLN) photonic devices operating at room temperature. While dynamically controlling writing and reading operations within picosecond timescales poses a challenge, the devices are capable of resolving 102.8 4.6 ps time step with ‐0.89 dB loss per round‐trip and 197.7 6.6 ps time steps with ‐1.29 dB loss per round‐trip, respectively. These results imply that the devices are at the cutting edge of on‐chip technology, performing in the current state of the art at the single photon level. Both of the single photon buffers do not introduce any detrimental effects and provide a high signal‐to‐noise ratio (SNR). The room‐temperature, low‐loss, and voltage‐controlled TFLN buffers combine scalable architecture with relatively high buffering capacity in the sub‐nanosecond regime and are expected to unlock many novel photonics applications such as temporally multiplexed single photon sources.
Gene and Photothermal Combination Therapy: Principle, Materials, and Amplified Anticancer Intervention
Authors: Tang Fang , Ding Aixiang , Xu Yao , Ye Yingsong , Li Lin , Xie Rongjun , Huang Wei 
Published: September 2023

AbstractGene therapy (GT) and photothermal therapy (PTT) have emerged as promising alternatives to chemotherapy and radiotherapy for cancer treatment, offering noninvasiveness and reduced side effects. However, their efficacy as standalone treatments is limited. GT exhibits slow response rates, while PTT is confined to local tumor ablation. The convergence of GT and PTT, known as GT‐PTT, facilitated by photothermal gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, GT reciprocates PTT by sensitizing cellular response to heat, while PTT benefits GT by improving gene translocation, unpacking, and expression. Consequently, this integration presents a unique opportunity for cancer therapy with rapid response and improved effectiveness. Extensive efforts over the past few years have been dedicated to the development of GT‐PTT, resulting in notable achievements and rapid progress from the laboratory to potential clinical applications. This comprehensive review outlines recent advances in GT‐PTT, including synergistic mechanisms, material systems, imaging‐guided therapy, and anticancer applications. It also explores the challenges and future prospects in this nascent field. By presenting innovative ideas and insights into the implementation of GT‐PTT for enhanced cancer therapy, this review aims to inspire further progress in this promising area of research.
Analyzing genomic variation in cultivated pumpkins and identification of candidate genes controlling seed traits
Authors: Lee Chieh‐Ying , Wang Jaw‐Fen , Chang Chia‐Hui , Tung Chih‐Wei 
Published: September 2023

AbstractPumpkins are important vegetable crops widely grown worldwide, and seeds are considered a popular nutraceutical food and an excellent source of protein, oil, and vitamins. Seed size is one of the most important targets for commercial breeding in Cucurbita species; studies have shown that pumpkin seed size variation has a similar trend with fruit size, shape, and seed yield. However, few studies have been conducted to identify genetic loci controlling seed‐related traits in cultivated pumpkins. This study analyzed the genomic characteristics of pumpkin breeding materials of 321 Cucurbita accessions collected worldwide, including Cucurbita moschata, Cucurbita maxima, and Cucurbita pepo, using extensive single nucleotide polymorphisms obtained from the genotyping‐by‐sequencing method, significant genetic variations were identified within and between Cucurbita species. Four major cultivar fruit types were further revealed in C. moschata species, and significant differentiation patterns were detected in several chromosomal regions. A total of 15 significant loci associated with pumpkin seed traits were mapped through a genome‐wide association approach; 32 genes previously reported to be associated with seed size regulation in Arabidopsis and Oryza sativa were located in the intervals defined by linkage disequilibrium. Through this study, we gained a deep understanding of the genomic variation distribution across Cucurbita species. The available genetic resources and the associated genetic contents could be used in commercial pumpkin breeding and will facilitate molecular marker‐assisted selection in pumpkin seed trait improvement.
Smart Cities: GCC and Kuwait Experience
Authors: Elian Mohammad I. , Kisswani Khalid M. 
Published: September 2023

AbstractThis study has two main objectives. First, spread out attention toward modern urban modeling and smart cities development in the GCC countries in general and Kuwait in particular. Second, expand existing scholarly concern on digital urbanization notion beyond the scope of the worldwide developed economies. There is a need to include the GCC countries to the scholarly urban literature since such countries are now highly urbanized. Also, the knowledge-based economy is applied through adopting the digitalization processing toward offering public and private services to their communities. The study concludes that smart cities have become very much significant through offering preeminent solutions to several environmental, economic, and societal problems in urban regions. For the GCC, it is crucial to identify the concept and structure of the targeted smart city initiative which should be linked to the country’s national strategic vision. Additionally, what proxies are used to judge on how smart is a city? Not less important, adopting the smart cities format would require overcoming significant limitations in order to overcome urban pressures through introducing the smart cities initiatives.
A Comprehensive Smart System for the Social Housing Sector
Authors: Shahrour Isam 
Published: September 2023

AbstractThis chapter presents a comprehensive smart system for the social housing sector which considers technical, social, and environmental issues. The chapter is composed of four sections. The first section discusses the challenges of the social housing sector with an emphasis on the social and environmental dimensions. The second section presents the research methodology, including an analysis of the expectations of the tenants and the social housing manager and the specifications for the design of the comprehensive smart system. The third section describes the architecture of the smart system, including the stakeholders’ communication channels, the monitoring system, and the smart services. The last section shows an application of smart system to a renovated social housing residence. The chapter shows that the comprehensive smart system should go beyond the smart building concept by extending this concept to the construction of a smart community and the involvement of this community in the improvement of the social housing environment.