bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESPGHAN and NASPGHAN 2023 protocol for paediatric FAPD treatment guidelines (standard operating procedure)
Authors: Gordon Morris , Benninga Marc A , Borlack Rachel , Borrelli Osvaldo , Chogle Ashish , Darbari Anil , Dolinsek Jernej , Groen Jip , Khlevner Julie , Di Lorenzo Carlo , Person Hannibal , Saps Miguel , Sinopoulou Vassiliki , Snyder Julie , Tabbers Merit , Thapar Nikhil , Vlieger Arine 
Published: December 2023

IntroductionTo date, no international guidelines have been published for the treatment of paediatric functional abdominal pain disorders (FAPDs), subcategorised into functional abdominal pain–not otherwise specified (FAP-NOS), irritable bowel syndrome (IBS), functional dyspepsia and abdominal migraine (AM). We aim for a treatment guideline, focusing on FAP-NOS, IBS and AM, that appreciates the extensive array of available therapies in this field. We present the prospective operating procedure and technical summary protocol in this manuscript.MethodsGrading of Recommendations, Assessment, Development and Evaluation (GRADE) will be followed in the development of the guideline, following the approach as laid out in the GRADE handbook, supported by the WHO. The Guideline Development Group (GDG) is formed by paediatric gastroenterologists from both the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, as well as the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Also, one clinical psychologist with expertise in FAPDs is a voting member in the GDG. A final consensus list of treatment options is translated into ‘patient, intervention, comparison, outcome’ format options. Prospective agreement on the magnitude of health benefits or harms categories was reached through a Delphi process among the GDG to support grading of the literature.There will be a detailed technical evidence review with randomised controlled trial data that will be judged for risk of bias with the Cochrane tool. Recommendations are preferably based on GRADE but could also be best practice statements following the available evidence. A full Delphi process will be used to make recommendations using online response systems. This set of procedures has been approved by all members of the GDG.
Supporting your support staff during crises: recommendations for practice leaders to develop a relational workplace
Authors: Dakin Francesca , Rai Tanvi , Paparini Sara , Greenhalgh Trisha 
Published: December 2023

BackgroundThe workload and wellbeing of support staff in general practice has been critically understudied. This includes reception, secretarial and administrative workers who are critical in the daily practice function. Currently, only reception staff are mentioned in the evidence base on general practice working conditions, and all support staff are excluded from studies about the impact of the pandemic on healthcare workers’ work and wellbeing.AimTo outline the unique work support staff do, the additional burden it places on them, and how the symphony of crises in 2020–2023 compounded those burdens. Additionally, to provide practical advice for practice leaders on how to support staff wellbeing through developing a relational and psychologically safe working environment.MethodsThese findings are drawn from qualitative research (case studies built through observations, interviews and focus groups) conducted in 2022–2023.ResultsThrough theoretically informed analysis, we found that support staff do specialist intersectional guiding work to support patients, other staff, and the practice as a whole. We define this as lay translation, specialist-lay translation, and occupational translation. Under crises, the volume of this work grows, complexifies, and becomes more fragmented. Relational and supportive teams were more able to adapt to these challenges.DiscussionSupport staff should be recognised and enabled to perform these specialised roles. Therefore, we provide a set of recommendations for practice leaders to consider integrating into their own workplaces.
Stock Market Volatility Prediction Based on Robust GBM-GRU Model
Authors: Liao Chuyue , Chen Guoqing , Cai Siyang 
Published: December 2023

In this study, a corrective learning technique is proposed to enhance the time series forecasting accuracy of traditional intelligent algorithms and address issues with engineering data adaptability. The financial world makes substantial use of volatility, and forecasting stock market volatility has great significance. Because stock price time series are nonstationary and nonlinear, predicting stock market volatility is a significant difficulty. In this study, a simulation experiment using an approach for corrective learning is carried out. Over a 3-year period, a LightGBM-GRU model is created to predict the volatility of 126 equities from diverse industries over the length of the subsequent 10 min, utilizing LightGBM and GRU as base models and correctors, respectively. Even traditional and effective ensemble learning models can benefit from the corrective learning technique, which simultaneously improves accuracy and generalization, according to performance metrics like RMSPE, MAE, MSE, and RMSE. The research emphasizes how the contradiction within intelligent algorithms has changed from one of restricted generality to different engineering difficulties in the era of algorithm enrichment and large data. The corrective learning strategy offers a fresh method for simulating data.
A type C study of Braverman–Gaitsgory–Ginzburg’s construction of sln representations
Authors: Dong Zhijie , Ma Haitao 
Published: December 2023

In [Z. Fan, H. Ma and H. Xiao, Equivariant K-theory approach to [Formula: see text]-quantum groups, Publ. Res. Inst. Math. Sci. 58 (2022), no.3, 635–668], it is proved that the convolution algebra of the top Borel–Moore homology on the Steinberg variety of type [Formula: see text] realizes [Formula: see text], where [Formula: see text] is the fixed point subalgebra of involution on [Formula: see text]. So, the top Borel–Moore homology of the partial Springer fibers gives the representations of [Formula: see text]. In this paper, we study these representations using Schur–Weyl duality and Springer theory.
Novel approach of Hubble parameter in f(R,Tϕ) gravity
Authors: Shukla Bhupendra Kumar , Sofuoğlu Değer , Mishra Preeti 
Published: December 2023

The [Formula: see text] theory of gravity investigated by Harko et al. [T. Harko, F. S. N. Lobo, S. Nojiri and S. D. Odintsov, Phys. Rev. D 84 (2011) 024020; T. Harko, Phys. Rev. D 90(4) (2014) 044067] serves as the inspiration for the homogeneous and isotropic cosmological model presented in generalized [Formula: see text] theories connected with a scalar field. Assuming that [Formula: see text] is the trace of the energy-momentum tensor, [Formula: see text] gravity can be understood as [Formula: see text] gravity with a self-interacting scalar field [Formula: see text]. To address this, we provide a novel model-independent method for the parametrization of the Hubble parameter, and we apply it to the Friedmann equations in the FLRW Universe. The Markov Chain Monte Carlo (MCMC) approach is then used to estimate the best-fit values of the model parameters using a combination of the updated [Formula: see text] dataset, which comprises 57 points, and the Pantheon dataset, which contains 1048 points. The evolution of the deceleration parameter shows a transition from the universe’s deceleration phase to its acceleration phase. We also investigate the behavior of the statefinder and the Om diagnostic parameter. Finally, a thorough discussion of the model’s physical attributes has been carried out.
Equitable coloring of planar graphs without 5-cycles and chordal 4-cycles
Authors: Wu Xianxi , Huang Danjun 
Published: December 2023

An equitable [Formula: see text]-coloring of a graph [Formula: see text] is a proper vertex coloring such that [Formula: see text] for any [Formula: see text], where [Formula: see text] ([Formula: see text]) is the set of vertices colored with [Formula: see text]. If there is an equitable [Formula: see text]-coloring of [Formula: see text], then the graph [Formula: see text] is said to be equitably [Formula: see text]-colorable. In this paper, we prove that every planar graph without 5-cycles and chordal 4-cycles has an equitable [Formula: see text]-coloring for [Formula: see text] where [Formula: see text] is the maximum degree of [Formula: see text].
A new genus and species of Encyrtidae (Hymenoptera: Chalcidoidea) with a four-segmented funicle from late Eocene Baltic amber
Authors: SIMUTNIK SERGUEI A. , PANKOWSKI MADELINE V. , PERKOVSKY EVGENY E. 
Published: December 2023

Electrocerus brevifuniculatus Simutnik gen. et sp. nov. is described and illustrated based on a female specimen from late Eocene Baltic amber. Placement of the new genus in the subfamily Encyrtinae is supported by the presence of a filum spinosum on the linea calva and the hypopygium not reaching the metasomal apex. A key to the genera of late Eocene Encyrtinae is provided. The new taxon differs from all known extinct and most extant encyrtids by its four-segmented female funicle.
Machine learning approach for Migraine Aura Complexity Score prediction based on magnetic resonance imaging data
Authors: Mitrović Katarina , Savić Andrej M. , Radojičić Aleksandra , Daković Marko , Petrušić Igor 
Published: December 2023

Abstract
Background
Previous studies have developed the Migraine Aura Complexity Score (MACS) system. MACS shows great potential in studying the complexity of migraine with aura (MwA) pathophysiology especially when implemented in neuroimaging studies. The use of sophisticated machine learning (ML) algorithms, together with deep profiling of MwA, could bring new knowledge in this field. We aimed to test several ML algorithms to study the potential of structural cortical features for predicting the MACS and therefore gain a better insight into MwA pathophysiology.

Methods
The data set used in this research consists of 340 MRI features collected from 40 MwA patients. Average MACS score was obtained for each subject. Feature selection for ML models was performed using several approaches, including a correlation test and a wrapper feature selection methodology. Regression was performed with the Support Vector Machine (SVM), Linear Regression, and Radial Basis Function network.

Results
SVM achieved a 0.89 coefficient of determination score with a wrapper feature selection. The results suggest a set of cortical features, located mostly in the parietal and temporal lobes, that show changes in MwA patients depending on aura complexity.

Conclusions
The SVM algorithm demonstrated the best potential in average MACS prediction when using a wrapper feature selection methodology. The proposed method achieved promising results in determining MwA complexity, which can provide a basis for future MwA studies and the development of MwA diagnosis and treatment.
Carbon nanofibers based carbon–carbon composite fibers
Authors: Hiremath Nitilaksha , Bhat Sunay , Boy Ramiz , Evora Maria Cecilia , Naskar Amit K. , Mays Jimmy , Bhat Gajanan 
Published: December 2023

AbstractTextile grade polyacrylonitrile (PAN) was used as a precursor material for carbon fiber preparation. E-beam irradiated polyacrylonitrile grafted carbon nanofibers were dispersed in polyacrylonitrile solution (dissolved in dimethyl formamide). Carbon nanofibers (CNF) infused polyacrylonitrile solution was wet spun on a lab-scale wet-spinning setup to form 50 to 70 µm diameter fibers with 3.2 wt.% CNF-PAN, 6.4 wt.% CNF-PAN, and neat PAN. Precursor fibers were characterized for thermal, mechanical and morphological properties using various techniques. Drawing the precursor fibers further enhanced polymer chain orientation and coalesced the voids, enhancing tensile strength and modulus by more than 150% compared to those of the undrawn fibers. Precursor composite fibers on carbonization showed enhanced strength, compared to that of pristine PAN fibers, by four times and stiffness by 14 times. The carbon–carbon composite fibers were further characterized with SEM/FIB, XRD and tensile strength. The property improvements were dependent on the uniform distribution of carbon nanofibers, and surface modification of carbon nanofibers further enabled their dispersion in the composite fibers. Furthermore, 3.2 wt.% CNFs in PAN fibers showed maximum improvement in properties compared to 6.4 wt.% CNF in PAN fibers, indicating that the property enhancements go through a maximum and then drop off due to challenge in getting uniform distribution of nanofibers.
Evaluation of intra-operative trans-urethral endoscopic management of possible open transvesical prostatectomy complications
Authors: Rohiem Mahmoud F. , Ibrahim Nesreen F. , Ali Mostafa Magdi , Ali Ahmed Issam 
Published: December 2023

Abstract
Objective
To evaluate the benefits of using transurethral cystoscope and resectoscope for managing possible complications that may occur during open transvesical prostatectomy operation.

Background
Open transvesical or retropubic prostatectomy remains, in less technologically developed countries, the standard option for treatment of complicated large benign prostatic hyperplasia. Complications rate with open prostatectomy procedures, especially post-operative bleeding and urinary incontinence, represent a real challenge facing urologists. Hopefully, recent advances in endourology section helped greatly in management of complicated benign prostatic hyperplasia and also offered a tool to deal with possible open prostatectomy complications.

Patients and methods
In a prospective study, fifty (50) male patients with complicated large benign prostatic enlargement associated with large single or multiple bladder stones with stone burden ≥ 3cm3 planned to undergo transvesical prostatectomy divided randomly into two groups. Group (A) included 25 patients who underwent standard T.V.P. and group (B) included 25 patients in whom diagnostic urethro-cystoscopy and a mono-polar resectoscope were used pre- and post-prostatic adenoma enucleation. Patients had follow-up evaluation visits at 1, 3 and 6 months postoperatively to evaluate IPSS, post-void urine estimation, Qmax., and quality of life.

Results
A total of 50 patients were divided equally into two groups. Group (A) included 25 patients who underwent standard transvesical prostatectomy, while group (B) included 25 patients who underwent initial diagnostic urethro-cystoscopy, then bilateral ureteric catheter insertion, followed by prostatic apical demarcation using a monopolar resectoscope. Finally, transurethral hemostasis of the prostatic bed is done after standard transvesical adenoma enucleation. Mean operative time in group (A): 48.3 ± 12.4 min. while in group (B): 68.9 ± 14.1 min (p < 0.001), Hemoglobin deficit in group (A): 2.8 ± 1.1 g/dl. while in group (B): 1.1 ± 0.39 g/dl. (p < 0.001). Enucleated prostate volume in group (A): 89.2 ± 16.1g, while in group (B): 91.2 ± 17.2g (p = 0.673). Post-operative IPSS, Post-void residual urine and Qmax showed insignificant differences between the two groups.

Conclusion
Trans-urethral endoscopically assisted transvesical prostatectomy provides more safety and fewer morbidities and complications rate compared to standard T.V.P.
Atypical presentation of testicular mesothelioma
Authors: Reed Sawyer Joseph , Nasui Stefanie , Farber Nicholas 
Published: December 2023

AbstractMesothelioma is a rare cancer that generally affects the lining of the lungs. However, in more rare cases, there are extra-pleural involvement of organs that are lined with mesothelial cells, including the testicle. Mesothelioma of the tunica vaginalis of the testicle typically presents with a painless scrotal mass with accompanying hydrocele of the affected side. The most common predisposition to mesothelioma of the tunica vaginalis is previous asbestos exposure, long-standing hydrocele, and previous scrotal surgeries. In this case we present a patient with isolated left tunica vaginalis mesothelioma of the testicle, yet without classic risk factors or other sites of disease. Left radical orchiectomy was performed and subsequent follow-up imaging did not reveal any sites of recurrence or metastasis. Although, mesothelioma of the tunica vaginalis is a rare cancer, it should be seen as a possible differential when evaluating new testicular masses.
A compressed large language model embedding dataset of ICD 10 CM descriptions
Authors: Kane Michael J. , King Casey , Esserman Denise , Latham Nancy K. , Greene Erich J. , Ganz David A. 
Published: December 2023

AbstractThis paper presents novel datasets providing numerical representations of ICD-10-CM codes by generating description embeddings using a large language model followed by a dimension reduction via autoencoder. The embeddings serve as informative input features for machine learning models by capturing relationships among categories and preserving inherent context information. The model generating the data was validated in two ways. First, the dimension reduction was validated using an autoencoder, and secondly, a supervised model was created to estimate the ICD-10-CM hierarchical categories. Results show that the dimension of the data can be reduced to as few as 10 dimensions while maintaining the ability to reproduce the original embeddings, with the fidelity decreasing as the reduced-dimension representation decreases. Multiple compression levels are provided, allowing users to choose as per their requirements, download and use without any other setup. The readily available datasets of ICD-10-CM codes are anticipated to be highly valuable for researchers in biomedical informatics, enabling more advanced analyses in the field. This approach has the potential to significantly improve the utility of ICD-10-CM codes in the biomedical domain.
TCGAplot: an R package for integrative pan-cancer analysis and visualization of TCGA multi-omics data
Authors: Liao Chenqi , Wang Xiong 
Published: December 2023

Abstract
Background
Pan-cancer analysis examines both the commonalities and heterogeneity among genomic and cellular alterations across numerous types of tumors. Pan-cancer analysis of gene expression, tumor mutational burden (TMB), microsatellite instability (MSI), and tumor immune microenvironment (TIME), and methylation becomes available based on the multi-omics data from The Cancer Genome Atlas Program (TCGA). Some online tools provide analysis of gene and protein expression, mutation, methylation, and survival for TCGA data. However, these online tools were either Uni-functional or were not able to perform analysis of user-defined functions. Therefore, we created the TCGAplot R package to facilitate perform pan-cancer analysis and visualization of the built-in multi-omic TCGA data.

Results
TCGAplot provides several functions to perform pan-cancer paired/unpaired differential gene expression analysis, pan-cancer correlation analysis between gene expression and TMB, MSI, TIME, and promoter methylation. Functions for visualization include paired/unpaired boxplot, survival plot, ROC curve, heatmap, scatter, radar chart, and forest plot. Moreover, gene set based pan-cancer and tumor specific analyses were also available. Finally, all these built-in multi-omic data could be extracted for implementation for user-defined functions, making the pan-cancer analysis much more convenient.\

Conclusions
We developed an R-package for integrative pan-cancer analysis and visualization of TCGA multi-omics data. The source code and pre-built package are available at GitHub (https://github.com/tjhwangxiong/TCGAplot).
Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly
Authors: Niu Caoyuan , Xu Kai , Hu Yanan , Jia Yanling , Yang Yuexia , Pan Xiaoyue , Wan Ruyan , Lian Hui , Wang Qiwen , Yang Juntang , Li Yajun , Rosas Ivan , Wang Lan , Yu Guoying 
Published: December 2023

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, the underlying mechanism of the disease remains elusive.

Methods
To evaluate the role of Tuftelin1 (TUFT1) in IPF and elucidate its molecular mechanism. We investigated the level of TUFT1 in the IPF and bleomycin-induced mouse models and explored the influence of TUFT1 deficiency on pulmonary fibrosis. Additionally, we explored the effect of TUFT1 on the cytoskeleton and illustrated the relationship between stress fiber and pulmonary fibrosis.

Results
Our results demonstrated a significant upregulation of TUFT1 in IPF and the bleomycin (BLM)-induced fibrosis model. Disruption of TUFT1 exerted inhibitory effects on pulmonary fibrosis in both in vivo and in vitro. TUFT1 facilitated the assembly of microfilaments in A549 and MRC-5 cells, with a pronounced association between TUFT1 and Neuronal Wiskott-Aldrich syndrome protein (N-WASP) observed during microfilament formation. TUFT1 can promote the phosphorylation of tyrosine residue 256 (Y256) of the N-WASP (pY256N-WASP). Furthermore, TUFT1 promoted transforming growth factor-β1 (TGF-β1) induced fibroblast activation by increasing nuclear translocation of pY256N-WASP in fibroblasts, while wiskostatin (Wis), an N-WASP inhibitor, suppressed these processes.

Conclusions
Our findings suggested that TUFT1 plays a critical role in pulmonary fibrosis via its influence on stress fiber, and blockade of TUFT1 effectively reduces pro-fibrotic phenotypes. Pharmacological targeting of the TUFT1-N-WASP axis may represent a promising therapeutic approach for pulmonary fibrosis.
Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury
Authors: Nie Yuanpeng , Wang Liying , Liu Shengbo , Dai Chunlei , Cui Tianjiao , Lei Yan , You Xinru , Wang Xiaohua , Wu Jun , Zheng Zhihua 
Published: December 2023

AbstractAcute kidney injury (AKI) is a common kidney disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low kidney targeting and undesired side effects, the existing antioxidant and anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential to develop effective nanodrugs with high renal targeting and biocompatibility for AKI treatment. Herein, we reported a novel nanodrug for AKI treatment, utilizing poly(ursolic acid) (PUA) as a bioactive nanocarrier and resveratrol (RES) as a model drug. The PUA polymer was synthesized form ursolic acid with intrinsic antioxidant and anti-inflammatory activities, and successfully encapsulated RES through a nanoprecipitation method. Subsequently, we systemically investigated the therapeutic potential of RES-loaded PUA nanoparticles (PUA NPs@RES) against AKI. In vitro results demonstrated that PUA NPs@RES effectively scavenged ROS and provided substantial protection against H2O2-induced cellular damage. In vivo studies revealed that PUA NPs significantly improved drug accumulation in the kidneys and exhibited favorable biocompatibility. Furthermore, PUA NPs alone exhibited additional anti-inflammatory and antioxidant effect, synergistically enhancing therapeutic efficacy in AKI mouse models when combined with RES. Overall, our study successfully developed an effective nanodrug using self-therapeutic nanocarriers, presenting a promising option for the treatment of AKI.
Graphical abstract