bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beliefs, observability and donation revision in charitable giving: evidence from an online experiment
Authors: Gao Guanlin , Shi Xinyan 
Published: January 2024

Abstract
This study examines how beliefs interact with heterogeneous donation preferences in determining people's donation decisions and choices of revision and observability. We conducted an online experiment eliciting participants’ first-order beliefs, that is, beliefs about an average donor's contribution, with the opportunity of being recognized. We also provided the opportunity for donation revision to a group of randomly selected participants. Our study results show that people's first-order beliefs are positively correlated with their willingness to donate and their actual donations. Moreover, first-order beliefs also interact with people's heterogeneous donation preferences in jointly determining their decisions of donation revision and observability – their tendency to opt in for public recognition. Donors with low first-order beliefs and high donation preferences are most likely to opt in for recognition, but they are unlikely to revise their donations. Donors with high first-order beliefs and low donation preferences are most likely to revise their donations, but they are less likely to choose to be recognized. Donors with low first-order beliefs and low donation preferences display the lowest tendency toward revision and observability.
DEGREE OF SATISFIABILITY IN HEYTING ALGEBRAS
Authors: BUMPUS BENJAMIN MERLIN , KOCSIS ZOLTAN A. 
Published: January 2024

Abstract
We investigate degree of satisfiability questions in the context of Heyting algebras and intuitionistic logic. We classify all equations in one free variable with respect to finite satisfiability gap, and determine which common principles of classical logic in multiple free variables have finite satisfiability gap. In particular we prove that, in a finite non-Boolean Heyting algebra, the probability that a randomly chosen element satisfies

$x \vee \neg x = \top $

is no larger than

$\frac {2}{3}$

. Finally, we generalize our results to infinite Heyting algebras, and present their applications to point-set topology, black-box algebras, and the philosophy of logic.
The Out-of-Flock Dissident: An Interview with Kurdish – Syrian Writer Jan Dost
Authors: Askar Nuha 
Published: January 2024

AbstractThe recent Syrian uprisings have impacted all sectors of life and played a major role in redrawing internal boundaries among different groups in Syria, not only between Kurds and Arabs but also within the fabric of Kurdish life. Among Syrian Kurds, calls for militarization and separation based on national chauvinism (Qasad) are countered by more moderate voices warning of the dangers of escalation and calling for Kurdish civilian rights within the Syrian homeland. Jan Dost is a Syrian–Kurdish writer whose literary oeuvre includes poetry books, numerous translations from and to Kurdish, and twelve novels, some of which have been translated into Turkish, Arabic, Sorani, Persian, and Italian. His criticism of what he calls “Kurdish fascism” prompted this interview, which is part of my current doctoral research on internal dissent in modern Middle Eastern narratives that negotiate the failure of “nationalism” in building modern states. Dost was born in Kobani in 1966 and has been living in Germany since 2000. His novel Mokhatat Petersburg (Petersburg Manuscript, 2020) was longlisted for the Sheikh Zayed Book Award. The interview is my translation from Arabic. It has been lightly edited for clarity and concision.
A monumental Archaic complex on the Sacra Via: a new interpretation of the domestic remains on the north Palatine slope
Authors: Eichengreen Amelia W. 
Published: January 2024

AbstractThis article presents a new interpretation of the results of the 1980s excavations led by Andrea Carandini on the north Palatine slope. In contrast to Carandini's original reconstruction of the complex as four atrium houses, I propose one palatial complex on the Sacra Via that finds some parallels in recently excavated complexes elsewhere, like the Auditorium site in Rome and the Borgo at San Giovenale.
L'amphithéâtre de Lepti Minus: un acte de munificence locale
Authors: Naddari Lotfi , Ben Lazreg Najib 
Published: January 2024

RésuméUn texte récemment mis au jour dans les environs de Lepti Minus (Lamta, dans le Sahel tunisien), gravé sur sur la face principale d'une base de statue, apporte un éclairage substantiel concernant l’édification de l'amphithéâtre de la ville: le contexte d‘édification, la nature du financement et l'identité des évergètes qui l‘ont pris en charge. Il s'agit donc d'un hommage public que le populus Leptitanorum a rendu à L. Octauius Felix, un notable local, membre de l'ordre équestre, coopté en qualité de patron de la cité. Le texte présente ainsi des centres d'intérêt multiples: des considérations onomastiques et sociales, le cursus équestre du notable laptitain, L. Octauius Felix, du primipilat, à la préfecture du camp de la Legio VII Gemina, en Espagne, et a prise en charge de la construction de l'amphithéâtre.
The Utilization of Emergency Department and Outpatient Clinics among Evacuated Victims after the 2023 Turkey Earthquake
Authors: İlhan Buğra , Eroğlu Oğuz , Çanak Hüseyin , Arıkan Abdullah , Sakallı Münir , Tursun Serkan , Deniz Turgut 
Published: January 2024

AbstractBackground:After the 2023 Turkey earthquake, thousands of people evacuated to different fields. Earthquake victims still need health care in the evacuation location. This study aims to determine the emergency department (ED) and outpatient clinic utilization characteristics of the evacuated earthquake victims outside the earthquake zone and to provide suggestions for planning the health care facilities in the regions where the evacuated earthquake victims will be placed.Methods:This retrospective, observational study was conducted in a tertiary university hospital from February 7, 2023 through February 20, 2023. All evacuated earthquake victims who presented to the study hospital were included in the study. Non-victim patients were included as the control group. Missing medical records were excluded. Demographic characteristics of the patients, outpatient clinics, International Statistical Classification of Diseases and Related Health Problems-10th Revision (ICD-10) codes, and outcomes were recorded.Results:A total of 15,128 patients were included in the final analysis. Six-hundred-nine (4.0%) of the patients were evacuated victims. Three-hundred forty-six (56.8%) evacuated victims used the ED. One-hundred fifty-six (25.6%) earthquake victims were in the pediatric age group. Earthquake victims used the ED more than the control group in adult and pediatric age groups (22.5% versus 51.7% and 30.2% versus 71.8%; P <.001, respectively). Earthquake victims frequently presented to the hospital during night shifts in both age groups (P <.05). Pediatric victims were more hospitalized than the control group (4.8% versus 10.9%; P = .001). Diseases of the respiratory system were the most common emergency diagnosis of the victims in both age groups (26.5% and 57.1%, respectively). The most frequently used outpatient clinic was ophthalmology in both age groups (14.6% and 20.5%, respectively).Conclusions:Evacuated victims, especially pediatric victims, used the ED more than other outpatient clinics. Diseases of the respiratory system were the most common emergency diagnosis of the victims, and the most frequently preferred outpatient clinic was ophthalmology. The most common diseases and frequently preferred clinics should be considered in planning health care for the evacuated earthquake victims.
Actionable conversational quality indicators for improving task-oriented dialog systems
Authors: Higgins Michael , Widdows Dominic , Hockey Beth Ann , Hazare Akshay , Howell Kristen , Christian Gwen , Mathi Sujit , Brew Chris , Maurer Andrew , Bonev George , Dunn Matthew , Bradley Joseph 
Published: January 2024

AbstractAutomatic dialog systems have become a mainstream part of online customer service. Many such systems are built, maintained, and improved by customer service specialists, rather than dialog systems engineers and computer programmers. As conversations between people and machines become commonplace, it is critical to understand what is working, what is not, and what actions can be taken to reduce the frequency of inappropriate system responses. These analyses and recommendations need to be presented in terms that directly reflect the user experience rather than the internal dialog processing.This paper introduces and explains the use of Actionable Conversational Quality Indicators (ACQIs), which are used both to recognize parts of dialogs that can be improved and to recommend how to improve them. This combines benefits of previous approaches, some of which have focused on producing dialog quality scoring while others have sought to categorize the types of errors the dialog system is making. We demonstrate the effectiveness of using ACQIs on LivePerson internal dialog systems used in commercial customer service applications and on the publicly available LEGOv2 conversational dataset. We report on the annotation and analysis of conversational datasets showing which ACQIs are important to fix in various situations.The annotated datasets are then used to build a predictive model which uses a turn-based vector embedding of the message texts and achieves a 79% weighted average f1-measure at the task of finding the correct ACQI for a given conversation. We predict that if such a model worked perfectly, the range of potential improvement actions a bot-builder must consider at each turn could be reduced by an average of 81%.
Secondary fragmentation and relative biological effectiveness (RBE) study using Bridge SOI microdosimeter: Monte Carlo simulation
Authors: Ying C. K. , Arif Efendi M. , Guatelli Susanna , Tran Linh T. , Bolst David 
Published: January 2024

Abstract

Introduction:
This work calculates the microdosimetric spectra and evaluates the relative biological effectiveness (RBE10) of oxygen and carbon ions using Monte Carlo simulation. This study presents a fast, reliable radiation field characterisation and accurate biological dose prediction tool in charged particle therapy for heavy-ion beams using the Bridge silicon-on-insulator (SOI) microdosimeter via Tool for Particle Simulation (TOPAS)-based simulations toolkit.

Method:
The study used the TOPAS simulation to model the Bridge SOI microdosimeter and study its response to carbon beams with an energy of 290 MeV/u and oxygen beams with an energy of 345 MeV/u. Dose-mean lineal energy values

$(\overline {{y_D})\;} $

and RBE10 values were evaluated using microdosimetric lineal energy spectra with the MKM model.

Results and Conclusions:
The results demonstrate that oxygen ion beams have an advantage for cancer treatment as they provide higher RBE10 values and occur at the same positions as the maximum physical dose (Bragg peak), compared to carbon ion beams. The study provides new understanding of RBE for carbon and oxygen ions, as well as the relationship between physical doses and RBE.
One‐Dimensional Variational Ionospheric Retrieval Using Radio Occultation Bending Angles: 2. Validation
Authors: Elvidge S. , Healy S. B. , Culverwell I. D. 
Published: January 2024

AbstractCulverwell et al. (2023, https://doi.org/10.1029/2023SW003572) described a new one‐dimensional variational (1D‐Var) retrieval approach for ionospheric GNSS radio occultation (GNSS‐RO) measurements. The approach maps a one‐dimensional ionospheric electron density profile, modeled with multiple “Vary‐Chap” layers, to bending angle space. This paper improves the computational performance of the 1D‐Var retrieval using an improved background model and validates the approach by comparing with the COSMIC‐2 profile retrievals, based on an Abel Transform inversion, and co‐located (within 200 km) ionosonde observations using all suitable data from 2020. A three or four layer Vary‐Chap in the 1D‐Var retrieval shows improved performance compared to COSMIC‐2 retrievals in terms of percentage error for the F2 peak parameters (NmF2 and hmF2). Furthermore, skill in retrieval (compared to COSMIC‐2 profiles) throughout the bottomside (∼90–300 km) has been demonstrated. With a single Vary‐Chap layer the performance is similar, but this improves by approximately 40% when using four‐layers.
Omics for deciphering oral microecology
Authors: Lin Yongwang , Liang Xiaoyue , Li Zhengyi , Gong Tao , Ren Biao , Li Yuqing , Peng Xian 
Published: January 2024

AbstractThe human oral microbiome harbors one of the most diverse microbial communities in the human body, playing critical roles in oral and systemic health. Recent technological innovations are propelling the characterization and manipulation of oral microbiota. High-throughput sequencing enables comprehensive taxonomic and functional profiling of oral microbiomes. New long-read platforms improve genome assembly from complex samples. Single-cell genomics provides insights into uncultured taxa. Advanced imaging modalities including fluorescence, mass spectrometry, and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing resolution. Fluorescence techniques link phylogenetic identity with localization. Mass spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for classification. Culturomics facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput approaches. Ongoing integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly, gene expression, metabolites, microenvironments, virulence mechanisms, and microbe-host interfaces in the context of health and disease. However, significant knowledge gaps persist regarding community origins, developmental trajectories, homeostasis versus dysbiosis triggers, functional biomarkers, and strategies to deliberately reshape the oral microbiome for therapeutic benefit. The convergence of sequencing, imaging, cultureomics, synthetic systems, and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict, prevent, diagnose, and treat associated oral diseases.
CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
Authors: Fu Xin , Zhang Qian , Wang Zhaosong , Xu Yue , Dong Qiuping 
Published: January 2024

AbstractOvarian cancer is the most lethal malignancy among gynecologic cancers, and primary and secondary chemotherapy resistance is one of the important reasons for poor prognosis of ovarian cancer patients. However, the specifics of resistance to chemotherapy in ovarian cancer remain unclear. Herein, we find that the expression level of cellular retinoic acid binding protein 2 (CRABP2) is up-regulated in drug-resistant ovarian cancer tissues and cell lines, and the expression levels of CRABP2 in epithelial ovarian cancer tissues are closely related to tumor clinical stage and patients’ prognosis, suggesting that CRABP2 plays an important role in the progression of ovarian cancer and the corresponding ability of tumor to chemotherapy. With the in-depth study, we demonstrates that CRABP2 is related to the high metabolic activity in drug-resistant cells, and all-trans retinoic acid exacerbates this activity. Further molecular mechanism exploration experiments show that CRABP2 not only up-regulates the expression level of HIF1α, but also increases the localization of HIF1α in the nucleus. In drug-resistant ovarian cancer cells, knocking down HIF1α can block the resistance of CRABP2 to chemotherapy drugs in ovarian cancer cells. Taken together, our findings suggest for the first time that CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α. This study provides a possible molecular mechanism for drug resistance and a possible molecular target for clinical treatment of ovarian cancer.
Carrier systems of radiopharmaceuticals and the application in cancer therapy
Authors: Zhang Taotao , Lei Huiwen , Chen Xiaohua , Dou Zhihui , Yu Boyi , Su Wei , Wang Wei , Jin Xiaodong , Katsube Takanori , Wang Bing , Zhang Hong , Li Qiang , Di Cuixia 
Published: January 2024

AbstractRadiopharmaceuticals play a vital role in cancer therapy. The carrier of radiopharmaceuticals can precisely locate and guide radionuclides to the target, where radionuclides kill surrounding tumor cells. Effective application of radiopharmaceuticals depends on the selection of an appropriate carrier. Herein, different types of carriers of radiopharmaceuticals and the characteristics are briefly described. Subsequently, we review radiolabeled monoclonal antibodies (mAbs) and their derivatives, and novel strategies of radiolabeled mAbs and their derivatives in the treatment of lymphoma and colorectal cancer. Furthermore, this review outlines radiolabeled peptides, and novel strategies of radiolabeled peptides in the treatment of neuroendocrine neoplasms, prostate cancer, and gliomas. The emphasis is given to heterodimers, bicyclic peptides, and peptide-modified nanoparticles. Last, the latest developments and applications of radiolabeled nucleic acids and small molecules in cancer therapy are discussed. Thus, this review will contribute to a better understanding of the carrier of radiopharmaceuticals and the application in cancer therapy.
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
Authors: Lei Wen , Zhao Ai , Liu Hui , Yang Chunmei , Wei Cheng , Guo Shanshan , Chen Zhilu , Guo Qunyi , Li Linjie , Zhao Mingzhe , Wu Gongqiang , Ouyang Guifang , Liu Ming , Zhang Jinyi , Gao Jimin , Qian Wenbin 
Published: January 2024

AbstractAlthough CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), disease relapse with tumor antigen-positive remains a challenge. Cytokine/chemokine-expressing CAR-T cells could overcome a suppressive milieu, but the clinical safety and efficacy of this CAR-T therapy remain unclear. Here we report the preclinical development of CD19-specific CAR-T cells capable of expressing interleukin (IL)-7 and chemokine (C-C motif) ligand (CCL)-19 upon CD19 engagement (referred to as 7 × 19 CAR-T cells) and results from a phase 1 and expansion phase trial of 7 × 19 CAR-T cell therapy in patients with R/R LBCL (NCT03258047). In dose-escalation phase, there were no dose-limiting toxicities observed. 39 patients with R/R LBCL received 7 × 19 CAR-T with doses ranged from 0.5 × 106–4.0 × 106 cells per kg body weight. Grade 3 cytokine release syndrome occurred in 5 (12.8%) patients and ≥ grade 3 neurotoxicity in 4 (10.3%) patients. The overall response rate at 3 months post-single infusion was 79.5% (complete remission, 56.4%; partial response, 23.1%). With a median follow-up of 32 months, the median progression-free survival was 13 months, and median overall survival was not reached, with an estimated rate of 53.8% (95% CI, 40.3% to 72.0%) at two years. Together, these long-term follow-up data from the multicenter clinical study suggest that 7 × 19 CAR-T cells can induce durable responses with a median overall survival of greater than 2 years, and have a manageable safety profile in patients with R/R LBCL.
Upregulated pexophagy limits the capacity of selective autophagy
Authors: Germain Kyla , So Raphaella W. L. , DiGiovanni Laura F. , Watts Joel C. , Bandsma Robert H. J. , Kim Peter K. 
Published: January 2024

AbstractSelective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrates, but whether these pathways can influence one another remains unknown. We address this question using pexophagy, the autophagic degradation of peroxisomes, as a model. We show in cells that upregulated pexophagy impairs the selective autophagy of both mitochondria and protein aggregates by exhausting the autophagy initiation factor, ULK1. We confirm this finding in cell models of the pexophagy-mediated form of Zellweger Spectrum Disorder, a disease characterized by peroxisome dysfunction. Further, we extend the generalizability of limited selective autophagy by determining that increased protein aggregate degradation reciprocally reduces pexophagy using cell models of Parkinson’s Disease and Huntington’s Disease. Our findings suggest that the degradative capacity of selective autophagy can become limited by an increase in one substrate.
Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice
Authors: Okonogi Toya , Kuga Nahoko , Yamakawa Musashi , Kayama Tasuku , Ikegaya Yuji , Sasaki Takuya 
Published: January 2024

AbstractThe vagus nerve crucially affects emotions and psychiatric disorders. However, the detailed neurophysiological dynamics of the vagus nerve in response to emotions and its associated pathological changes remain unclear. In this study, we demonstrated that the spike rates of the cervical vagus nerve change depending on anxiety behavior in an elevated plus maze test, and these changes were eradicated in stress-susceptible male mice. Furthermore, instantaneous spike rates of the vagus nerve were negatively and positively correlated with the power of 2–4 Hz and 20–30 Hz oscillations, respectively, in the prefrontal cortex and amygdala. The oscillations also underwent dynamic changes depending on the behavioral state in the elevated plus maze, and these changes were no longer observed in stress-susceptible and vagotomized mice. Chronic vagus nerve stimulation restored behavior-relevant neuronal oscillations with the recovery of altered behavioral states in stress-susceptible mice. These results suggested that physiological vagal-brain communication underlies anxiety and mood disorders.
Tunable and parabolic piezoelectricity in hafnia under epitaxial strain
Authors: Cheng Hao , Jiao Peijie , Wang Jian , Qing Mingkai , Deng Yu , Liu Jun-Ming , Bellaiche Laurent , Wu Di , Yang Yurong 
Published: January 2024

AbstractPiezoelectrics are a class of functional materials that have been extensively used for application in modern electro-mechanical and mechatronics technologies. The sign of longitudinal piezoelectric coefficients is typically positive but recently a few ferroelectrics, such as ferroelectric polymer poly(vinylidene fluoride) and van der Waals ferroelectric CuInP2S6, were experimentally found to have negative piezoelectricity. Here, using first-principles calculation and measurements, we show that the sign of the longitudinal linear piezoelectric coefficient of HfO2 can be tuned from positive to negative via epitaxial strain. Nonlinear and even parabolic piezoelectric behaviors are further found at tensile epitaxial strain. This parabolic piezoelectric behavior implies that the polarization decreases when increasing the magnitude of either compressive or tensile longitudinal strain, or, equivalently, that the strain increases when increasing the magnitude of electric field being either parallel or antiparallel to the direction of polarization. The unusual piezoelectric effects are from the chemical coordination of the active oxygen atoms. These striking piezoelectric features of positive and negative sign, as well as linear and parabolical behaviors, expand the current knowledge in piezoelectricity and broaden the potential of piezoelectric applications towards electro-mechanical and communications technology.