bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytic results for loop-level momentum space Witten diagrams
Authors: Chowdhury Chandramouli , Singh Kajal 
Published: December 2023

Abstract
This paper presents an evaluation of the wave function coefficients for conformally coupled scalars at both one and two-loop levels at leading order in the coupling constant, in momentum space. We take cues from time-dependent interactions in flat spacetime and under suitable approximations, these can also be used to study the wave function coefficients for general cosmologies. We make use of recursion relations developed in [20] to regularize certain bulk-point integrals and express the wave function coefficients in a form that simplifies the loop integrals. We utilize hard-cutoff regularization to regularize the loop integrals and further provide a discussion on their renormalization. Our results can also be analytically continued to obtain answers for transition amplitudes in AdS.
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Authors: Nöth Julia , Busch Wibke , Tal Tamara , Lai Chih , Ambekar Akhil , Kießling Tobias R. , Scholz Stefan 
Published: December 2023

AbstractInhibition of angiogenesis is an important mode of action for the teratogenic effect of chemicals and drugs. There is a gap in the availability of simple, experimental screening models for the detection of angiogenesis inhibition. The zebrafish embryo represents an alternative test system which offers the complexity of developmental differentiation of an entire organism while allowing for small-scale and high-throughput screening. Here we present a novel automated imaging-based method to detect the inhibition of angiogenesis in early life stage zebrafish. Video subtraction was used to identify the location and number of functional intersegmental vessels according to the detection of moving blood cells. By exposing embryos to multiple tyrosine kinase inhibitors including SU4312, SU5416, Sorafenib, or PTK787, we confirmed that this method can detect concentration-dependent inhibition of angiogenesis. Parallel assessment of arterial and venal aorta ruled out a potential bias by impaired heart or blood cell development. In contrast, the histone deacetylase inhibitor valproic acid did not affect ISV formation supporting the specificity of the angiogenic effects. The new test method showed higher sensitivity, i.e. lower effect concentrations, relative to a fluorescent reporter gene strain (Tg(KDR:EGFP)) exposed to the same tyrosine kinase inhibitors indicating that functional effects due to altered tubulogenesis or blood transport can be detected before structural changes of the endothelium are visible by fluorescence imaging. Comparison of exposure windows indicated higher specificity for angiogenesis when exposure started at later embryonic stages (24 h post-fertilization). One of the test compounds was showing particularly high specificity for angiogenesis effects (SU4312) and was, therefore, suggested as a model compound for the identification of molecular markers of angiogenic disruption. Our findings establish video imaging in wild-type strains as viable, non-invasive, high-throughput method for the detection of chemical-induced angiogenic disruption in zebrafish embryos.
Short-term and long-term efficacy in robot-assisted treatment for mid and low rectal cancer: a systematic review and meta-analysis
Authors: Wu Huiming , Guo Renkai , Li Huiyu 
Published: December 2023

Abstract
Objective
This study aims to conduct a meta-analysis to evaluate the short-term and long-term therapeutic effects of robot-assisted laparoscopic treatment in patients with mid and low rectal cancer.

Methods
A comprehensive search strategy was employed to retrieve relevant literature from PubMed, NCBI, Medline, and Springer databases, spanning the database inception until August 2023. The focus of this systematic review was on controlled studies that compared the treatment outcomes of robot-assisted (Rob) and conventional laparoscopy (Lap) in the context of mid and low rectal cancer. Data extraction and literature review were meticulously conducted by two independent researchers (HMW and RKG). The synthesized data underwent rigorous analysis utilizing RevMan 5.4 software, adhering to established methodological standards in systematic reviews. The primary outcomes encompass perioperative outcomes and oncological outcomes. Secondary outcomes include long-term outcomes.

Result
A total of 11 studies involving 2239 patients with mid and low rectal cancer were included (3 RCTs and 8 NRCTs); the Rob group consisted of 1111 cases, while the Lap group included 1128 cases. The Rob group exhibited less intraoperative bleeding (MD =  −40.01, 95% CI: −57.61 to −22.42, P < 0.00001), a lower conversion rate to open surgery (OR = 0.27, 95% CI: 0.09 to 0.82, P = 0.02), a higher number of harvested lymph nodes (MD = 1.97, 95% CI: 0.77 to 3.18, P = 0.001), and a lower CRM positive rate (OR = 0.46, 95% CI: 0.23 to 0.95, P = 0.04). Additionally, the Rob group had lower postoperative morbidity rate (OR = 0.66, 95% CI: 0.53 to 0.82, P < 0.0001) and a lower occurrence rate of complications with Clavien–Dindo grade ≥ 3 (OR = 0.60, 95% CI: 0.39 to 0.90, P = 0.02). Further subgroup analysis revealed a lower anastomotic leakage rate (OR = 0.66, 95% CI: 0.45 to 0.97, P = 0.04). No significant differences were observed between the two groups in the analysis of operation time (P = 0.42), occurrence rates of protective stoma (P = 0.81), PRM (P = 0.92), and DRM (P = 0.23), time to flatus (P = 0.18), time to liquid diet (P = 0.65), total hospital stay (P = 0.35), 3-year overall survival rate (P = 0.67), and 3-year disease-free survival rate (P = 0.42).

Conclusion
Robot-assisted laparoscopic treatment for mid and low rectal cancer yields favorable outcomes, demonstrating both efficacy and safety. In comparison to conventional laparoscopy, patients experience reduced intraoperative bleeding and a lower incidence of complications. Notably, the method achieves comparable short-term and long-term treatment results to those of conventional laparoscopic surgery, thus justifying its consideration for widespread clinical application.
Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study
Authors: Laamanen Suvi E. , Eloranta Aino-Maija , Haapala Eero A. , Sallinen Taisa , Schwab Ursula , Lakka Timo A. 
Published: December 2023

Abstract
Purpose
To investigate the associations of overall diet quality and dietary factors with serum biomarkers for lipid and amino acid metabolism in a general population of children.

Methods
We studied 194 girls and 209 boys aged 6–8 years participating in the Physical Activity and Nutrition in Children study. Food consumption was assessed by 4-day food records and diet quality was quantified by the Finnish Children Healthy Eating Index (FCHEI). Fasting serum fatty acids, amino acids, apolipoproteins, as well as lipoprotein particle sizes were analyzed with high-throughput nuclear magnetic resonance spectroscopy. Data were analyzed using linear regression adjusted for age, sex, and body fat percentage.

Results
FCHEI was directly associated with the ratio of polyunsaturated (PUFA) to saturated fatty acids (SFA) (PUFA/SFA), the ratio of PUFA to monounsaturated fatty acids (MUFA) (PUFA/MUFA), the ratio of PUFA to total fatty acids (FA) (PUFA%), the ratio of omega-3-fatty acids to total FA (omega-3 FA%), and inversely associated with the ratio of MUFA to total FA (MUFA%), alanine, glycine, histidine and very-low density lipoprotein (VLDL) particle size. Consumption of vegetable oils and vegetable-oil-based margarine (≥ 60% fat) was directly associated with PUFA/SFA, PUFA/MUFA, PUFA%, the ratio of omega-6 FA to total FA (omega-6 FA%), and inversely associated with SFA, MUFA, SFA to total FA (SFA%), MUFA%, alanine and VLDL particle size. Consumption of high-fiber grain products directly associated with PUFA/SFA, PUFA/MUFA, omega-3 FA%, omega-6 FA%, PUFA% and inversely associated with SFA and SFA%. Fish consumption directly related to omega-3 FA and omega-3 FA%. Consumption of sugary products was directly associated with histidine and VLDL particle size. Vegetable, fruit, and berry consumption had direct associations with VLDL particle size and the ratio of apolipoprotein B to apolipoprotein A1. Consumption of low fat (< 1%) milk was directly associated with phenylalanine. A higher consumption of high-fat (≥ 1%) milk was associated with lower serum MUFA/SFA and higher SFA%. Sausage consumption was directly related to SFA% and histidine. Red meat consumption was inversely associated with glycine.

Conclusions
Better diet quality, higher in intake of dietary sources of unsaturated fat and fiber, and lower in sugary product intake were associated with more favorable levels of serum biomarkers for lipid and amino acid metabolism independent of adiposity.

Trial Registration
ClinicalTrials.gov: NCT01803776, registered March 3, 2013.
Results of objective brushing data recorded from a powered toothbrush used by elderly individuals with mild cognitive impairment related to values for oral health
Authors: Flyborg Johan , Renvert Stefan , Anderberg Peter , Larsson Tobias , Sanmartin-Berglund Johan 
Published: December 2023

Abstract
Objectives
The study aimed to investigate how the objective use of a powered toothbrush in frequency and duration affects plaque index, bleeding on probing, and periodontal pocket depth ≥ 4 mm in elderly individuals with MCI. A second aim was to compare the objective results with the participants’ self-estimated brush use.

Materials and methods
Objective brush usage data was extracted from the participants’ powered toothbrushes and related to the oral health variables plaque index, bleeding on probing, and periodontal pocket depth ≥ 4 mm. Furthermore, the objective usage data was compared with the participants’ self-reported brush usage reported in a questionnaire at baseline and 6- and 12-month examination.

Results
Out of a screened sample of 213 individuals, 170 fulfilled the 12-month visit. The principal findings are that despite the objective values registered for frequency and duration being lower than the recommended and less than the instructed, using powered toothbrushes after instruction and information led to improved values for PI, BOP, and PPD ≥ 4 mm in the group of elderly with MIC.

Conclusions
Despite lower brush frequency and duration than the generally recommended, using a powered toothbrush improved oral health. The objective brush data recorded from the powered toothbrush correlates poorly with the self-estimated brush use.

Clinical relevance
Using objective brush data can become one of the factors in the collaboration to preserve and improve oral health in older people with mild cognitive impairment.

Trial registration
ClinicalTrials.gov Identifier: NCT05941611, retrospectively registered 11/07/2023.
Exterior Boundary-Value Poincaré Problem for Elliptic Systems of the Second Order with Two Independent Variables
Authors: Criado-Aldeanueva F. , Odishelidze N. , Sanchez J. M. , Khachidze M. 
Published: December 2023

AbstractThis paper offers a number of examples showing that in the case of two independent variables the uniform ellipticity of a linear system of differential equations with partial derivatives of the second order, which fulfills condition (3), do not always cause the normal solvability of formulated exterior elliptic problems in the sense of Noether.Nevertheless, from the system of differential equations with partial derivatives of elliptic type it is possible to choose, under certain additional conditions, classes which are normally solvable in the sense of Noether.This paper also shows that for the so-called decomposed system of differential equations, with partial derivatives of an elliptic type in the case of exterior regions, the Noether theorems are valid.
A 12-Month Follow-Up of PROCARE+, a Transdiagnostic, Selective, Preventive Intervention for Adolescents At-Risk for Emotional Disorders
Authors: Vivas-Fernandez Manuel , Garcia-Lopez Luis-Joaquin , Piqueras Jose A. , Espinosa-Fernandez Lourdes , Muela-Martinez Jose-Antonio , Jimenez-Vazquez David , Diaz-Castela Maria del Mar , Ehrenreich-May Jill 
Published: December 2023

AbstractFew studies have reported long-term follow-up data on selective preventive interventions for adolescents. No follow-up selective preventive transdiagnostic studies for adolescents at-risk for emotional disorders, such as anxiety and depression, have been reported. To fill this gap, this study aims to provide the first follow-up assessment of a randomized controlled trial (RCT) studying selective transdiagnostic prevention in at-risk adolescents. A 12-month follow-up assessment was conducted with subjects who originally received either PROCARE (Preventive transdiagnostic intervention for Adolescents at Risk for Emotional disorders), PROCARE+, which includes the PROCARE protocol along with personalized add-on modules or an active control condition (ACC) based on emotional psychoeducation, and their respective booster session for each experimental condition. 80 subjects (47.5% girls) aged between 12 and 18 years (M = 14.62; SD 1.43) who completed these treatment conditions were available for the 12-month follow-up. The results demonstrate the superior long-term efficacy of the PROCARE+ intervention in mitigating emotional symptoms and obsessive–compulsive symptomatology compared to the PROCARE and ACC conditions, with effect sizes notably exceeding those commonly observed in preventive programs. While the three treatments demonstrated beneficial impacts, the pronounced results associated with PROCARE+ at the 12-month follow-up emphasized the importance of personalized treatment modules and the sustained benefits of booster sessions in the realm of preventive psychological interventions. The findings also highlight the potential role of add-on modules in enhancing the effects of the PROCARE+ condition.
Interplay between climate change and climate variability: the 2022 drought in Central South America
Authors: Arias Paola A. , Rivera Juan Antonio , Sörensson Anna A. , Zachariah Mariam , Barnes Clair , Philip Sjoukje , Kew Sarah , Vautard Robert , Koren Gerbrand , Pinto Izidine , Vahlberg Maja , Singh Roop , Raju Emmanuel , Li Sihan , Yang Wenchang , Vecchi Gabriel A. , Otto Friederike E. L. 
Published: December 2023

AbstractSince 2019, Central South America (CSA) has been reeling under drought conditions, with the last 4 months of 2022 receiving only 44% of the average total precipitation. Simultaneously to the drought, a series of record-breaking heat waves has affected the region. The rainfall deficit during October–November-December (OND) is highly correlated with the Niño3.4 index, indicating that the OND 2022 rainfall deficit is partly driven by La Niña, as observed in previous droughts in this region. To identify whether human-induced climate change was also a driver of the OND 2022 rainfall deficit, we analysed precipitation over the most impacted region. Our findings revealed a pattern of decreased rainfall over the past 40 years, although we cannot definitively conclude whether this trend exceeds what would be expected from natural variations. To clarify if this trend can be attributed to climate change, we looked at 1-in-20-year low rainfall events over the same region in climate models. The models show that the severity of low rainfall events decreases (i.e. they become wetter, the opposite of the trend observed in most weather records), although this trend is again not significant and is compatible with natural variability. Therefore, we cannot attribute the low rainfall to climate change. Moreover, our analysis of effective precipitation potential (evapotranspiration minus rainfall) shows that, in climate models, the increase in temperature does partly compensate for the increase in rainfall but only to offset the wetting, and does not lead to a significant climate change signal in effective precipitation. However, higher temperatures in the region, which have been attributed to climate change, decreased water availability in the models in late 2022, indicating that climate change probably reduced water availability over this period also in the observations, increasing agricultural drought, although this study did not quantify this effect. This means that even though the reduced rainfall is within the natural variability, the consequences of drought are becoming more severe due to the strong increase in extreme heat. The case of the OND 2022 rainfall deficit and the ongoing drought in CSA is a clear example of the interplay between climate variability and human-induced climate change. This shows the importance of considering not only those aspects associated with climate change but also climate variability in order to understand and attribute particular events or trends at the regional level.
Comprehensive assessment of the carbon neutrality actions from the automotive sector
Authors: Princz-Jakovics Tibor , Csigéné Nagypál Noémi , Pálvölgyi Tamás 
Published: December 2023

AbstractThe aim of this paper is to analyse and demonstrate the carbon neutrality actions of a special facility in the context of the automotive sector. In order to analyse the emissions, a carbon simulation model is developed. Offsetting options are also overviewed in a systematic way. We provide a methodology for a systematic analysis of greenhouse gas (GHG) emissions and offsetting opportunities of an automotive facility. We compile an inventory of the carbon emissions, identify offsetting options and prepare a cost–benefit analysis of the mitigation actions. The relevance of United Nations Sustainable Development Goals (SDGs) is also assessed. We examine the GHG emissions of an automotive proving ground, ZalaZone in Zalaegerszeg, Hungary, as a case study. Four scenarios with various shares of decarbonisation options have been proposed to achieve the vision of net zero GHG emissions. It was found that net zero emission is achievable. The CBA concluded that the net present value is negative; however, there are significant external benefits. It was revealed that the operation of the facility contributes to multiple SDGs and provides different pathways to carbon neutrality.
Seasonal dynamic modeling and simulation of solar thermal membrane desalination system for sustainable freshwater production: a case study of Tanta, Egypt
Authors: El-Agouz S. A. , Elbar Ayman Refat Abd , Zayed Mohamed E. , Aboghazala Ali M. , Khatab Mohamed Z. , Zakaria M. Y. , Esmaeil Khaled Khodary 
Published: December 2023

AbstractMembrane distillation (MD) is an effective process for desalinating seawater, combining the merits of both thermal and membrane distillation. In this context, the sizing methodologies and optimization strategies are developed from the balance of the system’s energy demand. Therefore, accurate numerical modeling of the heat transfer and thermodynamic behavior of the MD systems is crucial for the optimal design of solar-based MD systems. The interest in utilizing solar thermal heating techniques for feed water heating in MD systems is increasing worldwide for sustainable freshwater production and lowering energy consumption. Hence, in this research, a coupled analytical modeling based on heat transfer, mass transport, and thermodynamic analysis is created to dynamically simulate a solar direct contact membrane distillation system (SDCMDS) driven by vacuumed tubes solar collectors (VTSCs) to analyze its performance, under real weather of Tanta, Egypt. The influences of the solar collecting area on the performances of the proposed SDCMDS for augmenting the freshwater production of the SDCMDS are studied. Four cases of the proposed SDCMDS are investigated: two identical VTSCs of 1.80 m2each unit in summer (Case I), two identical VTSCs in winter (Case II), four identical VTSCs in summer (Case III), and four identical VTSCs in winter (Case IV). The results show that the utilization of four VTSCs connected in series significantly improved the feed seawater temperature range from 30.0 to 70.5 °C compared to a feed temperature range of 30.0–49.5 was achievable by utilizing only two VTSCs. Moreover, the daily averaged permeate flux were 2.21, 1.29, 3.41, and 2.07 L/day per m2of solar harvesting area with daily cumulative distilled water yield of 7.48, 4.60, 23.04, and 14.78 L/day for Cases I, II, III, and IV, respectively, at a saline flowrate of 0.20 kg/s. The daily average total efficiency of the SDCMDS was obtained to be 14.70%, 12.50%, 24.95%, and 22.50% for Cases I, II, III, and IV, respectively.
Gendered Childhoods, Linear Sex Development and Unruly Temporalities
Authors: Garland Fae , Travis Mitchell 
Published: December 2023

AbstractThis article addresses a growing social and legal debate around healthcare provision for gender diverse children. Temporality is used as a theoretical lens to highlight how biological determinism has informed legal approaches to gender diverse children in a series of recent cases. In these cases, accounts of sex and gender as temporally linear are troubled by gender diverse children whose gender does not arise ‘inevitably’ from their sex. The Court’s reaction to this conflicts with recent shifts in healthcare which have begun to reframe the temporal pathways from childhood to adulthood away from singular towards multiple futures where gender is capable of being both ‘paused’ and ‘reversed’. Law’s commitment to ‘linearity’ and ‘permenance’ in its conceptions of the temporality of childhood are a key but emerging locus in the reinforcement of heteronormative temporalities downplaying contemporary harms to the child in favour of speculative future harm.
The Effect of the Fuel Location and Ventilation Factor on the Fire Dynamics of Informal Settlement Dwellings
Authors: Beshir M. , Wang Y. , Cicione A. , Hadden R. , Krajcovic M. , Rush D. 
Published: December 2023

AbstractThree full-scale experimental compartment fires are compared to investigate the effect of the fuel location and the ventilation factor on under ventilated thermally thin bounded ISO-9705 compartments. Wood cribs were used as the fuel load and the crib placement was varied between two locations (back and middle) to study the effect of the fuel location. Furthermore, the ventilation conditions were changed from a door and window (i.e., ventilation factor of 2.58 m5/2) to only a door (i.e., ventilation factor of 2.26 m5/2) for the scenario where the cribs were placed at the back of the compartment. The novelty of this work lies in its examination of the time to flashover, gas layer temperature, heat release rate, and external radiative heat fluxes, specifically considering the impact of fuel location and ventilation factor. It was observed that placing the fuel package in the middle of the compartment led to a longer growth phase, hotter gas layer temperature, a higher Heat Release Rate (HRR) needed for flashover ($$\dot{q}_{fo}$$

q
˙

fo

), and higher external radiative heat fluxes through openings. It was also found that, decreasing the ventilation factor decreased the heat losses and therefore the $$\dot{q}_{fo}$$

q
˙

fo

. Decreased ventilation also affected the height of the neutral plane, as one would expect, and the shape of the external plume, but did not have significant effect on the temperature within the compartment, the walls of the compartment, and the external radiative heat flux.