bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axillary Plexus Block for Anesthesia Management in Patients with Acute Compartment Syndrome after Primary Percutaneous Coronary Intervention (PCI) Transradial Approach: A Case Report
Authors: Renaldi  , I Made Gede Widnyana  , Otniel Adrians Labobar  
Published: December 2023

Background: Acute compartment syndrome is a rare complication of the percutaneous Coronary Intervention (PCI) transradial approach but it is very hand-threatening. Treatment for acute compartment syndrome is emergent fasciotomy of the affected compartments to reduce intracompartmental pressure. Axillary plexus block is an excellent choice of anesthesia technique for elbow, forearm, and hand surgery.
Case presentation: An 80-year-old, 60 kg, 168 cm man was consulted to our department with a painful swelling on his right upper arm and hand that began three hours after a primary PCI procedure. Previously, the patient had a history of hypertension and diabetes mellitus. The supporting examination results were notable for anemia (Hemoglobin 7,5 g/dL), thrombocytopenia (78 x103/uL), elevated hemostasis function (International Normalized Ratio 1.43), and high blood sugar (360 mg/dL) from echocardiography results anteroseptal and lateral hypokinetic. Before we did block, the patient was given ketamine 10 mcg IV and fentanyl 25 mcg IV for sedation. Axillary plexus block, as a type of regional anesthesia under ultrasound guidance, is a reliable substitute for general anesthesia in high-risk patients, and we do it with a dose of 20 ml of solution (50 mg (10 ml) isobaric bupivacaine 0.5% + 200 mg lidocaine 2% diluted with 20 ml normal saline). During the surgery, the patient was hemodynamically stable. After the operation, the patient was readmitted to the intensive cardiac care unit (ICCU).
Conclusion: Axillary plexus block can be an alternative to general anesthesia in patients who will undergo fasciotomy surgery after percutaneous coronary intervention transradial approach with stable hemodynamics during surgery and well-controlled pain after the surgery.
Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway
Authors: Lyu Zhuo-Zhen , Li Meng , Yang Ming-Yu , Han Mei-Hong , Yang Zhen 
Published: December 2023

BACKGROUND
Mesenchymal stem cells (MSCs) exert anti-oncogenic effects via exosomes containing non-coding RNA (ncRNA), which play important roles in tumor biology. Our preliminary study identified the interaction of the ncRNA hsa_circ_0000563 (circ563) and the circ563-associated miR-148a-3p in exosomes, as miR-148a-3p and its target metal-regulatory transcription factor-1 (MTF-1) are implicated in hepatocellular carcinoma (HCC) progression.
AIM
To identify the clinical significance, functional implications, and mechanisms of circ563 in HCC.
METHODS
The expression levels of miR-148a-3p and MTF-1 in exosomes derived from MSC and HCC cells were compared, and their effects on HCC cells were assessed. Using a dual-luciferase reporter assay, miR-148a-3p was identified as an associated microRNA of circ563, whose role in HCC regulation was assessed in vitro and in vivo .
RESULTS
The silencing of circ563 blocked the HCC cell proliferation and invasion and induced apoptosis. Co-culturing of HCC cells with MSC-derived exosomes following circ563 overexpression promoted cell proliferation and metastasis and elicited changes in miR-148a-3p and MTF-1 expression. The tumor-promoting effects of circ563 were partially suppressed by miR-148a-3p overexpression or MTF-1 depletion. Xenograft experiments performed in nude mice confirmed that circ563-enriched exosomes facilitated tumor growth by upregulating the expression of MTF-1. In HCC tissues, circ563 expression was negatively correlated with miR-148a-3p expression but positively correlated with MTF-1 levels.
CONCLUSION
MSCs may exhibit anti-HCC activity through the exosomal circ563/miR-148a-3p/MTF-1 pathway, while exosomes can transmit circ563 to promote oncogenic behavior by competitively binding to miR-148a-3p to activate MTF-1.
The boundary between the Prime Gaps and the Interchangeable be-tween a Quantum Mechanics System & a Classical Chaos One
Authors: Shun Lam Kai 
Published: December 2023

With reference to my last paper, this author found that there are always some discrete quantum constants like the Planck’s one laying between the real and the imaginary parts of the Riemann function (I.e when we fix or group the Riemann Zeros one by one and make the real part to be varying.) or the quantum mechan-ics system. Hence, the Riemann Zeta Zeros give us the discrete quantum con-stants together with the given discrete quantum constants may give you the wanted Riemann Zeta Zeros. This phenomenon may be explained by Quantum Riemann Zeta Epiphancy.	In the present paper, this author tries to fix or group the real part of the Riemann Zeros and make the imaginary part of the Riemann Zeros to be varying from one to the tenth one or resulting a chaos like graph. Thus, it seems that we may interchange a quantum mechanics system with the classical chaos one by just varying one variable and fix another one (such as varying real part of the Riemann function’s zeors from 0.1 to 1 and fix the imaginary part of the Rie-mann zeros one group after one another). Certainly, the vice versa for the fix of the real part (one group after another) with different Riemann Zeros may also help. In other words, the quantum mechanics system is just the conjugate pair (varying x and fixed y variables) of the classical chaos one or the vice versa is al-so true (fixed x and varying y variables) & put back into the Zeta functions etc. Hence, it is a method (or transformation) for us so that we may easily to make a interchange between these two systems by only adjusting or selecting which vari-ables to be varying or fixed. Then we may turn the classical chaos system into a quantum mechanics one or the vice versa. This implies that it may be possible to apply controllable quantum systems for the investigation of our natural aspects. Finally, this author have also shown that there is a boundary laying be-tween the prime gap through the elementary calculation and mathematical deriva-tion without using the computer software etc. It is thus a contradiction to the fact that there is no bound for the prime gap. This tells us that there is a need to have a shift from zero to 0.5 for the real part of the Riemann Zeta Zeros as what this author has mentioned in my last paper etc.
O impacto do ensino remoto emergencial e da utilização de tecnologias digitais na formação discente sob o olhar dos alunos do curso de pedagogia de uma instituição de ensino superior
Authors: Vieira Emmily Dos Santos , Ribeiro Mayara Cristina Martins , França Renata De Souza 
Published: December 2023

A tecnologia se consagrou como uma ferramenta essencial de interação e compartilhamento de informações durante o período pandêmico, aproximando pessoas e reduzindo a distância entre ignorância e conhecimento. Seguindo as determinações da Portaria nº 343 de 17 de março de 2020, da Nº 544, de 16 de junho de 2020 e da Medida Provisória Nº 934, de 1º de abril de 2020 do Ministério da Educação, a Instituição de Ensino Superior (IES) estudada, adotou o Ensino Remoto Emergencial. Nesse entendimento, o presente trabalho tem como objetivo analisar o impacto na formação de discentes do curso de Pedagogia de uma IES na região metropolitana de Belo Horizonte, causado pelo Ensino Remoto Emergencial e o uso da tecnologia durante período pandêmico. A pesquisa foi caracterizada como qualitativa e exploratória e a coleta de dados ocorreu por meio um questionário semiestruturado. O público alvo foi graduandos do curso de Licenciatura de Pedagogia. Após análise dos dados, chegou-se à conclusão de que o Ensino Remoto Emergencial afetou a aprendizagem, devido às dificuldades encontradas pelos discentes em lidar com as ferramentas tecnológicas e com o excesso de conteúdo a serem desenvolvidos exclusivamente pelos meios digitais e causou impacto considerável na realização do estágio curricular obrigatório, por ter limitado o acesso à interação, às práticas de intervenção pedagógica e o contato físico, elementos extremamente importantes no cenário educativo.
O olhar dos docentes acerca da promoção da formação continuada no espaço escolar para o ensino de Ciências: qual seria a temática de maior relevância para a prática pedagógica?
Authors: Amaral Joyce Frade Alves do , Barros Marcelo Diniz Monteiro de 
Published: December 2023

Este trabalho parte de uma pesquisa mais ampla que visa propor um curso de formação continuada ao docente em exercício nas escolas públicas do Rio de Janeiro, com foco nas metodologias ativas e tecnologias educacionais no ensino de Ciências, tem o propósito de identificar, se a oferta de um curso de formação continuada seria relevante para a melhoria e otimização da prática pedagógica no espaço escolar, já que é o lócus de atuação do professor, como também identificar qual temática seria de maior interesse do professor ao fazer o curso de formação, caso tenha interesse. Para isto, como instrumento de coleta de dados, foi aplicado um questionário destinado aos docentes do ensino fundamental utilizando o aplicativo google forms. A entrevista foi realizada na primeira quinzena de agosto de 2022. Os participantes foram os professores do ensino fundamental da rede municipal do Rio de Janeiro. A entrevista foi compartilhada nos grupos de whatsapp dos docentes no período de 01 à 15 de agosto de 2022 contando com a participação de 36 professores. A maioria dos professores entervistados (97,2%), sinalizou sobre a importância da oferta da formação continuada no espaço escolar. Os temas apontados de maior interesse a serem abordados no curso foram: educação inclusiva e tecnologias educacionais. Assim, chamamos a atenção para que se pense em formações continuadas a serem ofertadas no espaço de atuação do professor e que as mesmas sejam condizentes com a realidade tanto do docente quanto do aluno e que sobretudo possam contribuir fortemente para que o docente esteja sempre atualizado
O processo de validação de um instrumento para identificar indícios do PCK de Ciências Naturais para atuação na Educação Infantil
Authors: Quidigno Raquel De Abreu Fochesato , Camargo Sérgio , Zimer Tania Teresinha Bruns 
Published: December 2023

A presente investigação teve como objetivo validar um questionário que auxilie na investigação de indícios do Conhecimento Pedagógico do Conteúdo de Ciências Naturais de professores multidisciplinares para o contexto da Educação Infantil. Para tal, foi elaborado um questionário em três etapas: a primeira foi a identificação do participante, a segunda está relacionada ao CoRe (Representação do Conteúdo) e a terceira contendo perguntas complementares visando observar mais indícios do desenvolvimento do Conhecimento Pedagógico do Conteúdo de Ciências Naturais e as possíveis contribuições da formação inicial nesse contexto. O questionário foi validado com professores formados em Licenciatura em Pedagogia e/ou atuantes na Educação Infantil membros do Grupo de Pesquisa em Ensino e Aprendizagem em Ciências e em Matemática da Universidade Federal do Paraná. Com o processo de validação foi possível observar indícios do Conhecimento Pedagógico do Conteúdo de Ciências Naturais para o trabalho na Educação Infantil. Verificou-se, assim, a pertinência, as possibilidades e os limites das questões, permitindo validar o instrumento proposto.
Using Virtual Reality to Increase Nurses' Knowledge of Adolescent Suicide Precautions
Authors: Rappolt Emily L. , Hadenfeldt Cindy Jean 
Published: December 2023

Background:
Adolescents are disproportionately impacted by suicide, making it imperative nurses know how to identify those at high risk of suicide and provide safe care in the hospital setting. The purpose of this pilot study was to determine the efficacy of a virtual escape room as a learning strategy to increase nursing knowledge of suicide precautions for adolescent patients.

Method:
A 360-degree virtual escape room was developed to increase nursing knowledge of hospital policy related to suicide. Small groups of participants navigated through two virtual hospital rooms with embedded clues and questions related to suicide screening and precautions. Pretest-posttest questionnaires were used to measure changes in knowledge.

Results:
Nurses demonstrated improved knowledge of hospital policy following completion of the activity. Participants also expressed a high level of satisfaction with this form of learning.

Conclusion:

The use of a virtual escape room was an effective method for educating nurses on standards related to suicide prevention.

[
J Contin Educ Nurs
. 2024;55(4):165–168.]
Using Simulation Training to Reduce Skill Decay Among Certified Registered Nurse Anesthetists
Authors: Olson Joshua , Ko Arthur , Nowak Katherine A. , Latack Katie , Bozimowsky Gregory 
Published: December 2023

Background:
Skill decay refers to the loss of skills and knowledge resulting from lack of consistent use. Among certified registered nurse anesthetists (CRNAs), skill decay can lead to negative results. One method that has been shown to mitigate skill decay is low-dose, high-frequency (LDHF) simulation. There is a gap in the LDHF simulation literature regarding CRNAs to determine its effectiveness in reducing skill decay or increasing confidence levels.

Method:
This study used a quasi-experimental pretest-posttest follow-up design. The pretests and posttests were evaluated using a Wilcoxon signed rank test to determine CRNAs' proficiency and confidence in central venous catheter (CVC) insertion before and after a simulated refresher training course.

Results:

The CRNAs showed a significant improvement in CVC insertion proficiency, from a 50% pretest average to a 94% posttest average (
p
< .0001), and they retained proficiency 6 months later (91%,
p
= .0109). There was no significant change in CRNAs' confidence level following the training (
p
= .4486).

Conclusion:

A program of LDHF simulation training is an important activity in meeting the continuing education/training needs of CRNAs in improving and retaining CVC insertion proficiency. This study demonstrates the efficacy of a LDHF simulation program for CRNAs and helps to bridge the gap in the literature on the use of LDHF simulation among CRNAs.

[
J Contin Educ Nurs
. 2024;55(4):187–194.]
Photographier les ruines du Maroc à l’époque du Protectorat : les archives photographiques du Musée de l’Histoire et des Civilisations (Rabat)
Authors: Brahmi Néjat 
Published: December 2023

Le Musée de l’Histoire et des Civilisations de Rabat (Maroc) possède une collection de clichés et de négatifs qui datent de l’époque du Protectorat français (1912-1956). À partir de cette masse de données, nous établirons un état de ce fonds photographique. Nous constaterons ainsi que, d’un site à l’autre, ces archives sont très inégales. En effet, le site de Volubilis est relativement bien documenté alors que d’autres sites archéologiques importants sont marqués par une sous-représentation, voire l’absence d’image. Enfin, nous discuterons de l’intérêt à élaborer un instrument de recherche qui aurait vocation à être mis à la disposition de la communauté scientifique. Mais cette élaboration n’est pas sans poser de problèmes, notamment liés à la conservation des négatifs et des clichés, ainsi qu’à l’identification précise des ruines et objets photographiés.
Nationally representative epidemiological study of social anxiety disorder from India
Authors: Suhas Satish , Jayasankar Pavithra , Patley Rahul , Manjunatha Narayana , Rao Girish N. , Gururaj Gopalkrishna , Varghese Mathew , Benegal Vivek ,   NMHS National Collaborators group
Published: December 2023

Background:
Social anxiety disorder (SAD), also termed as social phobia, is a disabling psychiatric condition with limited epidemiological research on it in India. This study, using data from the National Mental Health Survey (NMHS), 2016, is the first to explore its current prevalence and associated factors in India.

Materials and Methods:
The NMHS in India used a comprehensive population-based study with subjects selected through a multistage stratified random cluster sampling technique across 12 states. The study included 34,802 adults interviewed with the Mini-International Psychiatric Interview 6.0.0. Firth penalized logistic regression (FPLR) was used to estimate covariate odds ratios (ORs), and the treatment gap for SAD and disability measured using Sheehan's disability scale was calculated.

Results:
The study found a 0.47% prevalence of SAD, with an average age of 35.68 years (standard deviation (SD) = 15.23) among those affected. Factors, such as male gender, unemployment, and living in urban areas, were associated with higher odds of SAD, while the elderly had lower odds. A significant proportion of individuals with SAD experienced disability in work (63%), social life (77%), and family life (68%). They spent a median of ₹ 2500 per month on treatment and had a high rate of comorbid psychiatric disorders (58%). The treatment gap was substantial at 82%.

Conclusions:
A considerable portion of India's population (approximately >65 lakhs) is affected by SAD. Surprisingly, the NMHS 2016 report indicates a higher risk of SAD among males compared with females, a trend that warrants further investigation. SAD in India is linked to significant disability and a considerable treatment gap, emphasizing the need for innovative approaches to address this large, affected population, especially in light of the scarcity of mental health professionals.
Mental health morbidities in Kerala, India: Insights from National Mental Health Survey, 2015–2016
Authors: Jyrwa Sonakshi , Shibukumar T. M. , Thavody Jayakrishnan , Anish P. K. , Bina Thomas , Rajith K.R. , Banandur Pradeep S. , Rao Girish N. , Gururaj Gopalkrishna , Varghese Mathew , Benegal Vivek 
Published: December 2023

Background:
The National Mental Health Survey was borne out of the felt need for a comprehensive epidemiological survey on mental health to understand the magnitude of psychiatric morbidities in India to aid in mental health policymaking, service planning, and delivery. Kerala was one of the 12 surveyed states, representing southern India.

Aims:
To estimate the prevalence and pattern of various mental illnesses and substance use disorders in a representative sample from Kerala state.

Settings and Design:
A household survey using a multi-stage, stratified, random cluster sampling technique, with selection based on probability proportionate to size at each stage.

Materials and Methods:
The community-based survey was carried out by trained field staff on individuals from systematically selected households from three randomly selected districts of Kerala. The instruments used in the survey included M.I.N.I adult version 6.0, a modified version of the Fagerström Nicotine Dependence Scale and questionnaires to screen for epilepsy, intellectual disability, and autism spectrum disorders.

Results:
A total of 2479 respondents aged >18 years were interviewed. The lifetime and current prevalence of mental morbidity (excluding tobacco use disorders) was 14.14% and 11.36%, respectively. Neurotic/stress-related disorders and depressive disorders were 5.43% and 2.49%, respectively, while severe mental disorders were prevalent in 0.44% of the sample. The prevalence of high risk for suicide was 2.23%.

Conclusions:
The survey revealed high rates of common mental illnesses and suicide risk in the state when compared to national estimates.
ARN14974=BOC tedavisine bağlı intrasellüler seramid değişimi aracılı proapoptotik ve antikanser etkilerin insan küçük hücreli dışı akciğer kanserinde araştırılması
Authors: KUS Gokhan , VEJSELOVA SEZER Canan , YAYLACI Ömer Koray , ÇÖMLEKÇİ Emre , KUTLU Hatice Mehtap 
Published: December 2023

Sfingolipidler hücre membran yapısında bulunan ve kanser hücresinde sinyalleşme işlevlerini kontrol ederek büyüme, proliferasyon, göç, metastaz gibi biyolojik fonksiyonları düzenlemekte olan moleküllerdir. Kanser tedavisinde son yıllardaki araştırmalar, kanser hücrelerindeki sfingolipid sinyalleşmesini hedef alan, yenilikçi moleküler ve farmakolojik araçlar kullanılarak tümör büyümesinin ve kemoterapi, radyoterapi ve/veya immünoterapiye yanıtta sfingolipidlerin ve alt hedeflerinin rolü hakkında mekanik ayrıntılar bulmayı amaçlamıştır.
Akciğer kanseri ülkemizde ve dünyada en sık görülen kanser türlerindendir. Kanser kaynaklı ölümlerin önemli bir kısmı akciğer kanserine bağlıdır. Akciğer kanseri için yeni ve etkili tedavi yöntemlerinin geliştirilmesine her gün daha çok ihtiyaç duyulmaktadır.
Bu çalışmada, ARN14974=BOC seramidaz inhibitörünün katı lipit nanopartikül formunun sentezlenmesi ile seramidin hücre içi seviyesini arttırarak hücrenin yaşamını ve proliferasyonunu sağlayan ve apoptozu inhibe eden seramidaz-1-fosfatın oluşumunu engelleyerek yeni ve etkili bir tedavi yaklaşımının küçük hücreli dışı akciğer kanseri hücre hattı A549 hücrelerinde araştırılması amaçlanmıştır.
Çalışma sonuçları ARN14974=BOC’un ve nanopartikül formunun A549 hücrelerinde sitotoksik ve antiproliferatif etkileri tespit edilmiş ve bu hücrelerde apoptozu gösteren morfolojik ve ince yapısal değişiklikler saptanmıştır. Bu moleküllerin A549 hücrelerinde reaktif oksijen türlerinin artması ve hücre döngüsünün durdurulmasına neden olarak apoptozu tetiklemiştir. Bu sonuçlar, insan küçük hücreli dışı akciğer kanseri hücrelerinde hücre ölümünün sentezlenen ARN14974=BOC’un nanopartikül formu tarafından daha etkin bir biçimde gerçekleştirildiğini göstermiştir.
THE INFLUENCE OF HUMAN RESOURCE COMPLIANCE AUDIT ON EMPLOYEE PERFORMANCE OF PUBLIC UNIVERSITIES IN WESTERN KENYA
Authors: Cherubet Beldine , Otsyulah Joseph , Mackton Wanyama S. 
Published: December 2023

A human resource compliance audit is one of the critical aspects of the universities that helps ensure all the policies, procedures, and practices of the university are adhered to by the management and other employees. Employee performance has been reported to be low in many universities. This is because of non-adherence to the university policies and practices. Therefore, the main objective of this study was to establish the effect of human resource compliance audits on employee performance at public universities in Western Kenya. The study was based on human capital theory. The study adopted a descriptive research design. The target population for the study was 187 respondents comprising 9 human resource managers, 9 deputy human resource managers, 121 human resource officers, and 48 internal auditors in all public universities in Western Kenya. Stratified random sampling was used to select 127 respondents. Questionnaires were used to collect primary data. Reliability was tested using Cronbach’s alpha and validity using experts and factor analysis. Descriptive and inferential statistics were used to analyze data. Regression analysis indicated that human resource compliance audits had a positive and significant influence on employee performance. It was, therefore, established that a unit increase in compliance audit would lead to the subsequent increase in employee performance by 0.178 units. The study established that 61.6% variation in employee performance was caused by human resource audit. The study findings will be useful for policy-making in public and private universities and form a basis for future studies by contributing to the pool of existing literature. The study recommended that universities should plan for compliance audits at least twice per year. It was also recommended that the university should put in place relevant internal control measures that will help in tracking each employee.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0011/a.php" alt="Hit counter" /></p>