bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Controlled Clinical Trial Evaluating the Performance of Bis-GMA Free Resin Composite Posterior Restorations
Authors: Reda Sara Ahmed , Hussein Yasser Fathi , Riad Mona 
Published: October 2023

Objective: This study aims to assess the clinical performance of Bis-GMA free resin composites (RCs) in comparison with Bis-GMA based resin composites as posterior restorations during 1,3,6,9, and 12 months, using a split-mouth, double-blinded randomized design. Methods and Materials: The study included 20 participants who received a pair of class I or II bulk-fill composite restorations. One side of the mouth was filled with Bis-GMA free RC (Admira Fusion x-tra), while the other side received Bis-GMA based RC (X-tra fil). Restoration placement was done by a single operator following the manufacturer's guidelines and was finished and polished immediately following placement. Modified United States Public Health Services (USPHS) criteria have been adopted for restoration assessment at baseline (1 week), 1, 3, 6, 9, and 12 months. The statistical analysis was accomplished utilizing Wilcoxon tests, with a 0.05 significance level. Results: After 12 months, all patients attended the recall visits with a 100% recall rate. The Wilcoxon signed rank tests revealed insignificant differences between both groups (p?0.05) for all USPHS parameters. The two studied materials showed a decline from 100% clinically excellent scores, with a few recordings of clinically good scores at 12 months. However, most restorations maintained clinical Alpha and Bravo score throughout the 12-month period. Conclusions: The Bis-GMA-free RCs' clinical performance was comparable to that of Bis-GMA-based RCs in posterior permanent teeth restorations after 12 months. These findings suggest that Bis-GMA-free RCs can be considered a viable alternative to Bis-GMA-based RCs in clinical practice.
Genotype distribution of hepatitis C virus in the province of Gaziantep, a 10-year evaluation
Authors: Cırıt Osman Sezer , Demir Yelda , Yıldırım Mehmet Saıt , Alpaslan Buket , Avcıoglu Fatma , Doğan Yusuf , Astam Pınar 
Published: October 2023

AbstractHepatitis C virus (HCV) can cause both acute and chronic hepatitis infections. Gaziantep is located southeast part of Turkey and has a border with Syria. More than 400,000 Syrian refugees live in Gaziantep. The aim of this study was to evaluate distribution of HCV genotypes among Syrian patients and in people who inject drugs.Serum samples form 1,628 individuals (786 female, 842 male) which were sent to our laboratory for genotyping between January 2013 and December 2022, were analyzed retrospectively. Three different HCV genotyping assays (Qiagen, RTA and Abbott) were used during the 10-year study period.Out of the 1,628 patients, genotype 1 was detected in 51.5%, genotype 3 in 21.4%, genotype 4 in 20%, genotype 5 in 4.6%, genotype 2 in 1.3%. Mixed genotype was found in 20 patients. Of the patients, 1,143 were Turkish patients and among those patients genotype 1 (66.8%) was the most common genotype followed by genotype 3 (29%). Among Syrian patients (n = 477), genotype 4 (64.2%) was predominant genotype followed by genotype 1 and genotype 5. Genotype 3 was detected in 277 (79.6%) prisoners. All of them were male and probably the main source of HCV infection was intravenous drug abuse. While genotypes 1 and 4 were common in females, genotypes 1 and 3 were common in males.In the future genotype 3 may become an increasing problem due to the persons who inject drugs. Less frequent genotypes such as 4 and 5 may become more frequent due to Syrian patients.
Mechanisms of impaired expression of p53-responsive microRNA genes in diffuse B-large cell lymphoma
Authors: Voropaeva E. N. , Pospelova T. I. , Churkina M. I. , Gurazheva A. A. , Berezina O. V. , Maksimov V. N. 
Published: October 2023

Introduction. A more in-depth description of molecular events that disrupt the functioning of the p53 signaling pathway is important for understanding the mechanisms of formation and progression of diffuse B-large cell lymphoma (DCCL), as well as its sensitivity to treatment. The p53 protein exhibits its oncosuppressive function and mediates the antitumor effects of drugs by regulating transcription and/or maturation of a wide range of target genes, including MIR-34A, MIR34B/C, MIR-129-2 and MIR-203. In the tumor tissue of lymphomas, in comparison with normal lymphoid tissue, a decrease in the level of microRNAs encoded by these genes is shown.Aim. The aim of this study was to conduct a comprehensive analysis of the methylation of the genes of the p53-responsive microRNAs MIR-34A, MIR-34B/C, MIR-203 and MIR-129-2, as well as mutations in the DNA-binding domain and destruction of the polyadenylation signal of the TP53 gene in DLBCL.Materials and methods. 136 DNA samples isolated from tumor tissue of patients with DLBCL and 11 DNA samples obtained from lymph nodes with reactive B-cell follicular hyperplasia were analyzed. The methylation status of MIR-203 and MIR-129-2 genes was determined by the method of methyl-specific polymerase chain reaction, MIR-34A and MIR-34B/C genes by the method of methyl-sensitive analysis of high-resolution melting curves. In tumor samples, rs78378222 genotyping was performed by polymerase chain reaction with restriction fragment length polymorphism, resulting in the destruction of the polyadenylation signal, and the nucleotide sequence of the region of the TP53 gene encoding the DNA-binding domain was determined by capillary direct sequencing by Sanger.Results. The methylation detected in lymphoma tissue was tumor-specific. The frequency of analyzed aberrations in the TP53 gene and methylation of MIR-34A, MIR-34B/C, MIR-129-2 and MIR-203 was 21, 23, 55, 65 and 66 %, respectively. At the same time, methylation of the analyzed genes of p53-responsive microRNAs and aberrations in the TP53 gene in the tumor tissue of patients with DLBCL were independent events with a tendency to mutual exclusion. At the same time, it was shown that in the vast majority of lymphoma samples, the methylation of the MIR-34A, MIR-34B/C, MIR-129-2 and MIR-203 genes was combined.Conclusion. Along with aberrations in TP53, methylation of MIR-34A, MIR-34B/C, MIR-129-2 and MIR-203 genes may be an important cause of decreased expression of miR-34a, miR-34b, miR-34c, miR-129 and miR-203 in DLBCL. The combined methylation of the MIR-203, MIR-129-2 and MIR-34B/C genes, as well as the MIR-34B/C and MIR-34A pairs, potentially has a more pronounced pro-tumor effect due to the presence of common targets in the microRNAs encoded by them.
Expression of the cytoskeletal proteins – cytokeratins and beta-III tubulin in human melanoma cell lines from the collection of N. N. Blokhin National Medical Research Center of Oncology
Authors: Bogush T. A. , Mizaeva I. E. , Basharina A. A. , Grishanina A. N. , Baryshnikova M. A. , Burova O. S. , Rudakova A. A. , Kosorukov V. S. 
Published: October 2023

Introduction. Despite advances in the treatment of melanoma, the results of therapy cannot be considered satisfactory, and the search for new drugs and effective combinations of medicine continues. The drugs are being developed aimed at reducing the metastatic tumor potential – migrastatics. The targets of the drugs can be cytoskeletal proteins of tumor cells – cytokeratin (CK) intermediate filaments and microtubule protein beta-III tubulin (TUBB3).Aim. To estimate of the CK and TUBB3 expression in melanoma cell lines to form an informative in vitro cell model for screening and studying migrastatics.Materials and methods. The molecular phenotype of 21 human melanoma cell lines from the collection of N. N. Blokhin National Medical Research Center of Oncology, and 18 of which were isolated from tumor metastases in the lymph nodes, soft tissues or subcutaneously. The level of TUBB3 expression and de novo expression of CKs in vimentin-expressing cells (CK + Vim) were assessed by an immunofluorescent method and flow cytometry.Results. Beta-III tubulin expression was detected in all cultures studied, de novo expression of CKs was found in 20 / 21 lines. The exception was primary uveal melanoma 92-1, that did not express CK + Vim. Both parameters significantly differed between the cells of the studied panel: CK + Vim co-expression – from 0 to 91 %, TUBB3 – from 18 to 86 %. No correlation was found between the expression level of TUBB3 and CK + Vim (Pearson’s correlation coefficient r = 0.11; p = 0.65). Three groups of the cell lines with different ratio of TUBB3 expression and CK + Vim co-expression were identified: 1) similar level of expression of both markers; 2) the level of co-expression of CK + Vim more or less high than the index for TUBB3; 3) the level of TUBB3 expression more or less high than the index for CK + Vim co-expression.Conclusion. A panel of 21 human melanoma cell lines was formed with quantitatively estimated expression of cytoske-letal proteins responsible for the migration activity of tumor cells – CKs and TUBB3. Groups of the lines with different expression ratio of the markers can be used for screening and preclinical evaluation potential migrastatics that reduce the metastatic potential of melanoma and may reduce resistance to taxanes.
Prognostic fine needle aspiration biopsy of uveal melanoma: Molecular and genetic factors of metastasis risk
Authors: Yarovaya V. A. , Levashov I. A. , Zaretsky A. R. , Chudakova L. V. , Nazarova V. V. , Matyaeva A. D. , Demidov L. V. , Yarovoy A. A. 
Published: October 2023

Introduction. Molecular genetic testing is actively used for prognostication in patients with uveal melanoma (UM). Tissue for genetic analysis may be obtained either by surgical excision or through fine-needle aspiration biopsy (FNAB). Performing genetic testing and FNAB in each institution can differ in surgical techniques and laboratory methodologies.Aim. To present our own experience of performing FNAB-based molecular genetic testing for prognostication in patients with uveal melanoma.Materials and methods. Prognostic FNAB (n = 151) were combined with brachytherapy or stereotactic surgery. Genetic testing was performed by methods based on polymerase chain reaction (GNAQ, GNA11, EIF1AX and SF3B1 mutations) and fluorescence in situ hybridization (copy numbers of PPARG and MYC genes); cytology of FNAB material was also assessed.Results. Fine-needle aspiration biopsy material was informative in 91 % of cases. At the median follow-up of 36 months, 12 cases of distant metastases were detected. Occurrence of the assessed mutations and copy numbers were related to other representative studies. PPARG deletion was shown to be a significant prognostic factor for metastasis-free survival (p <0,01), which was demonstrated for the first time; EIF1AX and SF3B1 mutations, MYC amplification and cytological class were not shown to be significantly associated with survival in our study.Conclusion. FNAB-based molecular genetic testing for prognostication in patients with uveal melanoma was shown to be a reliable and highly informative approach. Some of the prognostic factors need to be evaluated further with longer follow-up.
Peramalan nilai tukar rupiah terhadap dollar Amerika menggunakan model ARIMA
Authors: Wijaya Andreas Rony 
Published: October 2023

The exchange rate of the Rupiah against the currencies of other countries is one of the factors in identifying the condition of an economic condition. The value exchange rate can be strengthened or weakened at any time, according to the country's situation. Fluctuations of the Rupiah exchange rate could affect domestic inflation. Therefore, it is necessary to plan a good policy, considering the Rupiah's movement in the future. One of the currencies that affect the world's economic conditions is the United States Dollar. This study forecasts the Rupiah's exchange rate against the United States Dollar (USD). Data is obtained from Bank Indonesia, with the period of the data used from January 2018 to August 2022. One method of forecasting time series data is the Autoregressive Moving Average (ARIMA) method. The best model is selected based on the smallest AIC and BIC values. Based on the analysis of model selection, the ARIMA(1, 0, 1) model is the best model for forecasting the exchange rate of the Rupiah against the US Dollar. The results of the prediction of the Rupiah exchange rate show that the exchange rate of the Rupiah against the US Dollar has increased and decreased, which was not significant. Keywords: ARIMA, exchange rate, forecasting, time seriesMSC2020: 62M10
Translation and psychometric testing of Indonesian Version of Chronic Kidney Disease– Symptom Burden Index
Authors: Wasilah Hinin , Natashia Dhea , Huang Chen-Hui , Chen Hsing Mei , Yen Miaofen 
Published: October 2023

Introduction: Chronic Kidney Disease Symptom Burden Index (CKD-SBI) is an instrument measuring symptom burden developed by Almutary and colleagues in 2015 to refine the identification of symptom burden in chronic kidney disease population. This instrument has not been tested for Indonesian language, thus, the aim of study was to translate and psychometrically testing the Indonesian version of CKD-SBI.
Methods: This study design was cross-sectional study. The study methods were divided into translation and psychometric testing. The translation was conducted by adapting Guillemin and Beaton's guidelines. The psychometric properties determined 320 hemodialysis patients with several inclusion criteria such as above 18 years old, regularly receiving hemodialysis for more than 3 months. Patients with cognitive impairment, psychiatric patients, and in critical condition were excluded.
Results: The item content validity index of the Indonesian version was 0.92, and the subscale content validity was 0.78. The instrument demonstrated convergent validity with the Kidney Disease Quality of Life. Excellent internal consistency was demonstrated based on a Cronbach’s alpha coefficient of .91 and a subscale ranging from 0.86 to 0.92. The confirmatory factor analysis showed that the five factors of English Version did not fit the Indonesian version.
Conclusions: Translated Indonesian versions of CKD-SBI can be used as instruments to assess symptom burden among patients with hemodialysis. By assessing symptom burden, we hope nurses in the hospital are able to decide effective symptom management to increase the health-related quality of life among these populations.
IMPROVING UNDERSTANDING OF THE DANGERS OF DRUG ABUSE IN ADOLESCENT CHILDREN THROUGH PSYCHOEDUCATIONAL ACTIVITIES
Authors: Al Imtinan Baliylah , Reymiza Farhaniaz Salmaa , Arianatagati Katarina Fieschi Stella , Thezeus Hartati Pragita , Aryani Dinda , Cahyanti Ika Yuniar 
Published: October 2023

Introduction: This study aims to determine the effect of psychoeducation regarding drug abuse on participants, namely students of the Muhammadiyah Gayungan Orphanage.
Methods: This study used a psychoeducation program in the form of interactive talk shows and psychoeducational video summaries about drug abuse at the Muhammadiyah Gayungan Orphanage. The target participants of this study were 11 children at the Muhammadiyah Gayungan Orphanage. This study used a pretest-posttest design with one group of participants. The data analysis technique used was the independent sample t-test.
Results: With a mean difference score of 30.9, providing psychoeducation had a significant effect on increasing adolescent knowledge on drug abuse at Muhammadiyah Gayungan Orphanage (t(11) = 5.49, p = <.001, Cohen's d = 1.65).
Conclusion: Psychoeducation regarding drug abuse proved to have a significant effect on the understanding of children at the Muhammadiyah Gayungan Orphanage regarding knowledge of drug abuse.
KEYWORDS
adolescent; drug abuse; psychoeducation.
KNOWLEDGE AND SKILL OF BASIC TRAUMA AND CARDIO LIFE SUPPORT AMONG UNDERGRADUATE NURSING STUDENTS
Authors: Suarilah Ira , Sriyono Sriyono , Nihayati Hanik Endang , Makhfudli Makhfudli , Wahyudi Andri Setiya 
Published: October 2023

Introduction: Basic trauma and cardio life support (BTCLS) is primarily focused on ensuring widespread and uniform implementation of life saving. Classical face to face teaching method and practices have been widely applied in higher nursing education to increase cognitive and psychomotor. The Aim of this community service was to increase knowledge and skills of BTCLS among undergraduate nursing students.
Methods: BTCLS program was delivered through lecture, demonstration, and simulation. The instrument used was developed by the Indonesia emergency and disaster nurse association (HIPGABI). A self-report paper-based questionnaire was applied to measure the level of knowledge and skills. Data was analysed by descriptive statistics.
Results: The demographic characteristic of participants were dominated by group of age 18 to 30 year-old (85.56%), female (73.33%), and those who have no clinical working experience (68.89%). The lowest education and skill scored was management of trauma whom were 55.56% passed and 70% was high skill. The pre-test showed around 60% participants was passed. The post-test, 100% participants met the pass level of each category with the highest knowledge and skill’s score was basic life support. After the whole program delivered, all participants convened the knowledge and more than 80% categorised as high skill.
Conclusion: The given training program showed face to face teaching, simulation, and demonstration improved knowledge and skills related to BTCLS benefited participants. The BTCLS education and training highlighted knowledge should be periodically updated, technical skills should be consolidated, and sufficient equipment’s should be established in accordance with training and certified trainer.
INVENTANDO EL PASADO. LA FAMILIA JUDEOCONVERSA HERRERA DE CÓRDOBA Y GRANADA. /
Authors: Quevedo Sánchez Francisco I. 
Published: October 2023

(ES)Resumen: El de judíos y conversos ha sido un tema especialmente recurrente para la historiografía española, aunque los especialistas se han centrado mayoritariamente en la relación de éstos con la Inquisición, obviando, en gran medida, el análisis de su integración en la sociedad cristiano vieja y de su capacidad de ascenso. Aquí mostramos uno de los muchos ejemplos de familias de origen converso que mediante el poder del dinero y el engaño genealógico, entre otras estrategias, lograron alcanzar las filas de la nobleza castellana.Palabras clave: conversos, genealogía, estrategias, ocultación, ascenso. (EN)Abstract: Jews and conversos has been a common issue for the Spanish historians although they only focus in the relationship between them and the Inquisition. As a result of that, we have not analysis of his integration in the Christian Society and his upward mobility. This article presents one of the many examples we have of one family with jewish ancestors whose members could become part of the nobility, in spite of his legacy, using his economical power and the genealogical hiding.Key Words: Converses, Genealogy, Strategies, Ascension, Hiding.
Dynamic Properties of Remote Sensing Algorithm in Digital Resistance Elements
Authors: Romaniuk F. A. , Rumiantsev V. Y. , Novash I. V. , Rumiantsev Y. V. 
Published: October 2023

In microprocessor-based distance protection of lines, digital resistance elements are used as measuring instruments for determining the components of the input resistance vector and their subsequent mathematical comparison with the boundaries of the selected response characteristics. The values of the resistance vector components are calculated from the voltages and currents measured at the installation site of the protection. The most common are algorithms for remote measurements of input resistance based on: two samples of instantaneous values of line voltage and current; line models; using orthogonal voltage components and current. In the resistance elements of modern microprocessor line protections for remote measurements, the last of the above algorithms is most widely used. Its dynamic properties are determined mainly by the implemented method of generating the orthogonal components of the input signals. In distance protection measuring device, non-recursive digital Fourier filters are predominantly used for this purpose. To improve the dynamic properties of the remote measurement algorithm based on them, it is proposed to correct additionally dynamic errors in transient modes. In the dynamic modeling environment MATLAB-Simulink-SimPowerSystems, digital model is implemented that allows for a comparative assessment of the dynamic properties of the proposed algorithm for remote measurements of input resistance based on the results of a computational experiment. The research results have shown that the proposed algorithm for remote measurements of input resistance has higher dynamic properties compared to the known ones.
On the Feasibility of Building Mini-Thermal Power Plant Using Local Fuels in the Conditions of the Republic of Belarus. Part 1. State of Use of Local Fuels in Heat Supply Systems
Authors: Sednin V. A. , Ignatovich R. S. , Iokova I. L. 
Published: October 2023

As part of ensuring the country's energy security and pursuing a policy of decarbonization of the economy in the Republic of Belarus, the maximum use of its own fuel and energy resources (FER) is expected. However, the question of choosing the type of heat source in centralized heat supply systems when using local fuels (LF) remains open. The commissioning of the Belarusian Nuclear Power Plant and the relatively high specific cost of electricity generating capacities using local fuels tip the scales to the use of boiler houses as heat sources. However, world experience in the development and application of heating, as the most energy-efficient solution in the field of heat supply, requires a more thorough study of this problem. The paper presents an overview of the use of local fuels in Belarus and a number of European countries with developed centralized heat supply. Based on the analysis of open source data, the paper provides information on the state of use of local fuels in district heating systems of the Republic of Belarus and a number of European countries that have experience in the widespread use of solid biomass and where it constitutes a significant share in the structure of thermal and electrical energy production in relation to other fuel and energy resources. The main aspects of the energy programs of a number of European countries with the largest share of thermal and electrical energy generation using local fuels are presented. It has been revealed that the energy program of Finland is of the greatest interest for Belarus, where the share of nuclear energy in the structure of electrical energy production, just like in the Republic of Belarus, is approaching to 40 % and the energy strategy assumes an increase in the share of thermal power plants using local fuels in the structure of heat and electricity generation.