bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing family relations in borderline personality disorder: A relational approach
Authors: Roca Mariona , Vilaregut Anna , Pretel‐Luque Teresa , Calvo Natàlia , Frías Álvaro , Ferrer Marc 
Published: February 2024

AbstractThe aims of the current study are to describe the basic family relationships, parental bonding patterns, and dyadic adjustment of families with offspring diagnosed with borderline personality disorder (BPD) and to explore the correlations between these variables related to family relations and BPD symptomatology. The sample consisted of 194 participants, including parents from the control (N = 76) and clinical group (N = 76), and patients with BPD (N = 42). All progenitors completed a measure of family relations, parental bonding, and dyadic adjustment. Patients completed a measure of parental bonding and borderline symptomatology. The results showed significant differences between both groups in marital and parental functioning, marital satisfaction, dyadic adjustment, and care. Correlations among family variables and BPD symptomatology were also found. In summary, findings underscore the significance of comprehending the complexity of family relationships in BPD while advocating for a relational perspective when examining the family dynamics.
Dilutional rheology of Radiesse: Implications for regeneration and vascular safety
Authors: McCarthy Alec D. , Soares Danny J. , Chandawarkar Akash , El‐Banna Radia , Hagedorn Nadine 
Published: February 2024

AbstractBackgroundCalcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) injectables have emerged as dual‐purpose fillers with bioregenerative and direct filling capabilities.AimsThis study investigates the rheological properties of CaHA‐CMC and its CMC carrier gel at various dilutions.MethodsThe storage modulus (G′), loss modulus (G″), complex viscosity (η*), loss factor (tan δ), cohesivity, and extrusion force were evaluated for a range of CaHA‐CMC aqueous dilutions with an oscillatory rheometer, drop weight testing, and force analysis, respectively.ResultsResults revealed a significant decrease in G′, η*, and increase in tan(δ) with increasing dilution, indicating a decline in the product's direct filling capabilities. Cohesivity decreased dramatically with dilution, potentially enhancing tissue biointegration and the product's biostimulatory effects. The CMC gel carrier displayed inelastic and non‐resilient properties, with rheological changes differing from CaHA‐CMC. Dilutional rheology was also correlated with previously published dilution‐dependent biostimulatory data where hyperdiluted CaHA‐CMC (>1:2) demonstrated a regenerative profile and diluted or hypodiluted mixtures retained meaningful filling properties and increased regeneration.ConclusionsThese findings offer a continuum for tailoring the product's rheological profile to match specific tissue requirements. Customizable rheology allows CaHA‐CMC to be tuned for either filling and contouring or optimal regenerative effects. Importantly, safety implications related to vascular occlusion suggest that dilutional rheomodulation decreases the risk of vascular events. In conclusion, this study highlights the significant impact of aqueous dilution on the rheological properties of CaHA‐CMC and its carrier gel. The findings support the clinical application of tailored dilutions to achieve desired outcomes, providing versatility and safety for aesthetic applications.
The Equilibrium Size and Value‐Added of Venture Capital
Authors: SANNINO FRANCESCO 
Published: February 2024

ABSTRACTI model positive sorting of entrepreneurs across the high and low value‐added segments of the venture capital market. Aiming to attract high‐quality entrepreneurs, inefficiently many venture capitalists (VCs) commit to provide high value‐added by forming small portfolios. This draws the marginal entrepreneur away from the low value‐added segment, reducing match quality in the high value‐added segment too. There is underinvestment. Multiple equilibria may emerge, and they differ in aggregate investment. The model rationalizes evidence on VC returns and value‐added along fundraising “waves” and when the cost of entrepreneurship falls, and generates untested predictions on the size and value‐added of venture capital.
Ultrasonography use for tongue cancer management: A scoping review
Authors: Pires Duarte Luiz Cláudio , Teixeira Karlayle , Dias Barbara Magalhães Figueiredo , Fonseca Felipe Paiva , Travassos Denise Vieira , Smit Chané , Castro Maurício Augusto Aquino de , Sampaio Aline Araujo 
Published: February 2024

AbstractBackgroundTongue cancer is associated with debilitating diseases and poor prognostic outcomes. The use of imaging techniques like ultrasonography to assist in the clinical management of affected patients is desirable, but its reliability remains debatable. Therefore, the aim of this study is to investigate the importance of ultrasound use for the clinicopathological management of tongue cancer.MethodsA scoping review was carried out using specific search strategies in the following electronic databases: PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar. Collected data included bibliographical information, study design, ultrasound equipment, the aim of the ultrasonography use, the timing of ultrasound use during oncological treatment (pre‐, trans‐, and/or post‐operatively), and the advantages and disadvantages of the use of the ultrasound.ResultsA total of 47 studies were included in this review after following the selection process. The majority of the studies investigated the use of ultrasound pre‐operatively for the investigation of lymph node metastases or to determine the tumor thickness and depth of invasion. The sensitivity, specificity, and accuracy of ultrasound to determine clinical lymph node metastases ranged from 47% to 87.2%, from 84.3% to 95.8%, and from 70% to 86.2%, respectively. The sensitivity and specificity to determine the microscopic depth of invasion were 92.3% and from 70.6% to 82.1%, respectively.ConclusionUltrasonography seems to be a reliable imaging technique for the investigation of important prognostic parameters for tongue cancer, including depth of invasion and lymph node metastases.
Insights into the clinical presentation, diagnostics and outcome in dogs presenting with neurological signs secondary to infection with Neospora caninum: 41 cases (2014‐2023)
Authors: Fisher C. , Seferidis N. , Zilli J. , Roberts T. , Harcourt‐Brown T. 
Published: February 2024

ObjectivesTo describe the clinical signs and outcome of a large cohort of dogs presenting with neurological signs secondary to Neospora caninum infection.Materials and MethodsRetrospective review of cases presenting to two UK referral centres with neurological signs secondary to N. caninum infection between 2014 and 2023. Presenting signs, diagnostic test results, treatment, short‐ and long‐term outcome analysed.ResultsA total of 1690 cases were assessed for eligibility. Forty‐four cases with a diagnosis of neosporosis were obtained. Three cases were then excluded due to non‐neurological presentations (two hepatitis and one myocarditis). A total of 41 cases were included in the study. Cerebello‐vestibular signs predominated; however, presenting clinical signs were varied and the neurolocalisation was often multifocal in nature (46.3%), making neosporosis an important differential diagnosis for meningoencephalitis of unknown origin. Complete clinical improvement was rare (5.6%), and relapses were common (27.8% cases with follow‐up).Clinical SignificanceNeosporosis remains an important differential diagnosis for dogs at any age presenting with multifocal neurological signs. The outcome is considered poor and relapse rate is high.
Sraffian indeterminacy of steady‐state equilibria in the Walrasian general equilibrium framework
Authors: Yoshihara Naoki , Kwak Se Ho 
Published: February 2024

AbstractIn contrast to Mandler's generic determinacy of steady‐state equilibria, we first show that any non‐trivial steady‐state equilibrium is indeterminate under a general overlapping generation (OLG) economy with a fixed Leontief technique. We also check that this indeterminacy is generic. These results are obtained by explicitly introducing a general model of every generation's utility function and individual optimization program to the OLG economy, which also verifies that Mandler's claim on generic determinacy is invalid. We also argue the distinctiveness of our results in comparison with the standard literature of OLG indeterminacy.
Fine‐scale distribution of the lungworm Halocercus delphini in the lungs of the striped dolphin, Stenella coeruleoalba: implications about migration pathways and functional significance
Authors: Pool Rachel V. , Pons‐García Neus , Consoli Francesco , Rivero Miguel , Bombardi Cristiano , Raga Juan A. , Aznar Francisco J. 
Published: February 2024

AbstractDespite their high pathogenicity, limited knowledge is available on intrahost migration pathways and microhabitat distribution of pseudaliid lungworms. In this study, the distribution of Halocercus delphini in the lungs of the striped dolphin, Stenella coeruleoalba, was analyzed on three scales: between the right and left lungs, within the lungs, and between worm clusters. Evidence of a relationship between the distribution of H. delphini and the perfusion of the lungs of S. coeruleoalba is provided by the consistent correlation of these two factors, both on a longitudinal scale and by the difference in parasite burden between the left and right lung. This relationship, when coupled with the nested pattern of colonization, suggests that this species, like many other metastrongyloids, migrates to the lungs via the circulatory system. Additionally, the concentration of lungworms around the major airways could be a further reflection of the well‐perfused nature of these passageways. Equally, this distribution could be a strategy to minimize the distance that larvae must travel to exit the lungs via the trachea, as do most other metastrongyloids. On a more localized scale, the tendency of H. delphini to form distinct heterosexual clusters even at low infection intensities indicates active mate‐seeking behavior for reproduction.
Can humidifier reservoir bacteria colonize the circuit during mechanical ventilation: An in vitro study
Authors: Jia Yong‐Gang , Li Tian‐Ran , Lau Ricky Wing Tong , Lian Su‐Bing , Zhou Jin‐Yang , Liu Jie‐Ling , Pan Xia‐Zhen 
Published: February 2024

AbstractBackgroundAlthough the circuit condensate, an ideal bacterial reservoir during mechanical ventilation, may flow into the humidifier reservoir, no studies have investigated if humidifier reservoir colonized bacteria colonize other circuit locations with airflow.AimWe aimed to prove whether the humidifier reservoir colonized bacteria colonize other circuit locations with airflow and provide some advice on the disposal of condensate in the clinical setting.Study DesignAn in vitro experiment was conducted. Mechanical ventilation simulators (n = 90) were divided into sterile water group (n = 30) and broth group (n = 60). In the sterile water group, sterile water was used for humidification, either Acinetobacter baumannii or Pseudomonas aeruginosa were inoculated to humidifier water in the humidifier reservoir, each accounted for 50% of the simulators. The broth group was performed the same as the sterile water group except for the addition of broth into the humidified water. After 24, 72, and 168 h of continuous ventilation, the humidifier water and different locations of the circuits were sampled for bacterial culture.ResultsAll bacterial culture results of the sterile water group were negative. Bacteria in the humidifier water continued to proliferate in the broth group. With prolonged ventilation, the bacteria at the humidifier reservoir outlet increased. The bacteria at the humidifier reservoir outlet were much more in the Pseudomonas aeruginosa subgroup than in the Acinetobacter baumannii subgroup and the difference was statistically significant (p < .05). During continuous ventilation, no bacterial growth occurred at 10 cm from the humidifier reservoir outlet and the Y‐piece of the ventilator circuits.ConclusionsSterile water in the humidifier reservoir was not conducive to bacterial growth. Even if bacteria grew in the humidifier reservoir and could reach the humidifier reservoir outlet, colonization of further circuit locations with the airflow was unlikely. During a certain mechanical ventilation time, the amount of bacteria reaching the outlet of the humidifier reservoir varied due to different mobility of bacteria.Relevance to Clinical PracticeIn a clinical setting, nurses should not worry about a small amount of condensate backflow into the humidifier reservoir. Draining condensate into the humidifier reservoir can be used as a low risk and convenient method in clinical practice.
Should carbohydrate‐modified diets be the first option for weight loss in people with impaired glucose metabolism? A scoping review
Authors: Ellison Katie M. , Wyatt Holly R. , Hill James O. , Sayer R. Drew 
Published: February 2024

SummaryWhile the “precision nutrition” movement is at an early stage of development, several investigations have compared low‐fat versus carbohydrate (CHO)‐modified diets (i.e., low‐or‐reduced‐CHO, low glycemic index/load diets, and high‐fiber) in people with normal versus impaired glucose metabolism. The purpose of this scoping review was to summarize evidence in support of the hypothesis that CHO‐modified diets are more effective for weight loss among people with impaired glucose metabolism. Fifteen articles were included in this review: seven retrospective analyses of randomized clinical trials and eight prospective randomized clinical trials with prespecified hypotheses related to a diet (low‐fat vs. CHO‐modified) × phenotype (normal vs. impaired) interaction. Evidence in support of the hypothesis was identified in six of seven retrospective and three of eight prospective studies, which led to a recommendation of CHO‐modified diets as a first‐line option for people with impaired glucose metabolism. However, the evidence in support of this recommendation is relatively weak, and dietary prescriptions should consider additional contextual information that may influence overall dietary adherence. Additional and rigorous research using innovative randomized experimental approaches is needed for stronger dietary weight loss recommendations based on pretreatment glycemic status.
MORF9‐dependent specific plastid RNA editing inhibits root growth under sugar starvation in Arabidopsis
Authors: Xie Yakun , Yu Jinfa , Tian Faan , Li Xue , Chen Xinyan , Li Yanyun , Wu Binghua , Miao Ying 
Published: February 2024

AbstractMultiple organellar RNA editing factor (MORF) complex was shown to be highly associated with C‐to‐U RNA editing of vascular plant editosome. However, mechanisms by which MORF9‐dependent plastid RNA editing controls plant development and responses to environmental alteration remain obscure. In this study, we found that loss of MORF9 function impaired PSII efficiency, NDH activity, and carbohydrate production, rapidly promoted nuclear gene expression including sucrose transporter and sugar/energy responsive genes, and attenuated root growth under sugar starvation conditions. Sugar repletion increased MORF9 and MORF2 expression in wild‐type seedlings and reduced RNA editing of matK‐706, accD‐794, ndhD‐383 and ndhF‐290 in the morf9 mutant. RNA editing efficiency of ndhD‐383 and ndhF‐290 sites was diminished in the gin2/morf9 double mutants, and that of matK‐706, accD‐794, ndhD‐383 and ndhF‐290 sites were significantly diminished in the snrk1/morf9 double mutants. In contrast, overexpressing HXK1 or SnRK1 promoted RNA editing rate of matK‐706, accD‐794, ndhD‐383 and ndhF‐290 in leaves of morf9 mutants, suggesting that HXK1 partially impacts MORF9 mediated ndhD‐383 and ndhF‐290 editing, while SnRK1 may only affect MORF9‐mediated ndhF‐290 site editing. Collectively, these findings suggest that sugar and/or its intermediary metabolites impair MORF9‐dependent plastid RNA editing resulting in derangements of plant root development.
Generation of aroma in three‐line hybrid rice through CRISPR/Cas9 editing of BETAINE ALDEHYDE DEHYDROGENASE2 (OsBADH2)
Authors: Liao Yongxiang , Li Mengyuan , Wu Hezhou , Liao Yingxiu , Xin Jialu , Yuan Xinmiao , Li Yong , Wei Aiji , Zou Xuemei , Guo Daiming , Xue Zhenzhen , Zhu Guoxu , Wang Zhaoning , Xu Peizhou , Zhang Hongyu , Chen Xiaoqiong , Du Kangxi , Zhou Hao , Xia Duo , Ali Asif , Wu Xianjun 
Published: February 2024

AbstractAroma or fragrance in rice is a genetically controlled trait; Its high appreciation by consumers increases the rice market price. Previous studies have revealed that the rice aroma is controlled by a specific gene called BETAINE ALDEHYDE DEHYDROGENASE (OsBADH2), and mutation of this gene leads to the accumulation of an aromatic substance 2‐acetyl‐1‐pyrroline (2‐AP). The use of genetic engineering to produce aroma in commercial and cultivated hybrids is a contemporary need for molecular breeding. The current study reports the generation of aroma in the three‐line hybrid restorer line Shu‐Hui‐313 (SH313). We created knock‐out (KO) lines of OsBADH2 through the CRISPR/Cas9. The analysis of KO lines revealed a significantly increased content of 2AP in the grains compared with the control. However, other phenotypic traits (plant height, seed setting rate, and 1000‐grain weight) were significantly decreased. These KO lines were crossed with a non‐aromatic three‐line hybrid rice male sterile line (Rong‐7‐A) to produce Rong‐7‐You‐626 (R7Y626), R7Y627 and R7Y628. The measurement of 2‐AP revealed significantly increased contents in these cross combinations. We compared the content of 2‐AP in tissues at the booting stage. Data revealed that young spike stalk base contained the highest content of 2‐AP and can be used for identification (by simple chewing) of aromatic lines under field conditions. In conclusion, our dataset offers a genetic source and illustrates the generation of aroma in non‐aromatic hybrids, and outlines a straightforward identification under field conditions.
Low bleeding rates following transbronchial lung cryobiopsy in unclassifiable interstitial lung disease
Authors: Taverner John , Lucena Carmen M. , Garner Justin L. , Orton Christopher M. , Nicholson Andrew G. , Desai Sujal R. , Wells Athol U. , Shah Pallav L. 
Published: February 2024

AbstractBackground and ObjectiveBronchoscopic transbronchial lung cryobiopsy (TBLC) is a guideline‐endorsed alternative to surgical lung biopsy for tissue diagnosis in unclassifiable interstitial lung disease (ILD). The reported incidence of post‐procedural bleeding has varied widely. We aimed to characterize the incidence, severity and risk factors for clinically significant bleeding following TBLC using an expert‐consensus airway bleeding scale, in addition to other complications and diagnostic yield.MethodsA retrospective cohort study of consecutive adult outpatients with unclassifiable ILD who underwent TBLC following multidisciplinary discussion at a single centre in the UK between July 2016 and December 2021. TBLC was performed under general anaesthesia with fluoroscopic guidance and a prophylactic endobronchial balloon.ResultsOne hundred twenty‐six patients underwent TBLC (68.3% male; mean age 62.7 years; FVC 86.2%; DLCO 54.5%). Significant bleeding requiring balloon blocker reinflation for >20 min, admission to ICU, packed red blood cell transfusion, bronchial artery embolization, resuscitation or procedural abandonment, occurred in 10 cases (7.9%). Significant bleeding was associated with traction bronchiectasis on HRCT (OR 7.1, CI 1.1–59.1, p = 0.042), a TBLC histological pattern of UIP (OR 4.0, CI 1.1–14, p = 0.046) and the presence of medium‐large vessels on histology (OR 37.3, CI 6.5–212, p < 0.001). BMI ≥30 (p = 0.017) and traction bronchiectasis on HRCT (p = 0.025) were significant multivariate predictors of longer total bleeding time (p = 0.017). Pneumothorax occurred in nine cases (7.1%) and the 30‐day mortality was 0%. Diagnostic yield was 80.6%.ConclusionTBLC has an acceptable safety profile in experienced hands. Radiological traction bronchiectasis and obesity increase the risk of significant bleeding following TBLC.
Country characteristics and trade policy during the COVID‐19 pandemic
Authors: Hoekman Bernard , Santi Filippo , Shingal Anirudh 
Published: February 2024

AbstractGovernment policy responses to the COVID‐19 pandemic often included changes to trade policies. This article uses detailed data on trade policy measures targeting medical products during the first 18 months of the pandemic (January 2020–June 2021) compiled by the Global Trade Alert to analyze the relationship between national trade policy activism and pre‐pandemic trade patterns, import protection and international integration. The focus is on both potential country‐specific drivers of unilateral trade policies and the duration of implemented measures. We find significant heterogeneity in the relationships between trade policy actions and country characteristics. The likelihood of import liberalization was more prevalent among net exporters of medical products, whereas net importers were more inclined to impose export restrictions. The results suggest trade policy responses to the challenges raised by the COVID‐19 pandemic are only partially explained by extant theory.
Meeting empowerment: How styles of discursive frames vary across participatory settings
Authors: Stiman Meaghan 
Published: February 2024

AbstractOver the past few decades, there has been a resurgence of public participation in participatory settings. Such participatory processes are often long and arduous, and sometimes involve seemingly endless meetings of deliberation between various stakeholders and citizens before a policy decision or plan of action is made. While there is much known about the social forces that constrain how people deliberate in meetings, there is more to know about the discursive frames that actors use to deliberate and legitimize in these settings. To explore this, I draw on an analysis of a debate in a small coastal town surrounding a dam removal across two municipally sponsored spheres: listening sessions and select board meetings. I found that people debated the same issue differently across different contexts using different discursive frames, and the frames developed in the listening sessions were not transferable to select board meetings, the site where a policy decision was imminent. To explain this, I analyze how a meeting's empowerment in a given participatory process influences which styles of discursive frames actors use and are valued during deliberation. Understanding this provides a piece to the larger puzzle of what constrains and enables deliberative discourse in the 21st century.
Identity development in the digital context
Authors: Soh Serena , Talaifar Sanaz , Harari Gabriella M. 
Published: February 2024

AbstractDigital media is ubiquitous in adolescence and young adulthood. These are key developmental periods when people explore who they are and who they want to become. However, researchers have yet to fully understand digital media's role in shaping identity and its development. We build on prior work conceptualizing identity development as a contextually embedded process to describe how identity influences and is influenced by one's digital context. We propose a systematic framework for investigating the relationships between identity and digital environments (i.e., mediums and platforms, which vary according to their content and affordances) through four mechanisms: selection (i.e., choosing or avoiding digital environments), manipulation (i.e., intentionally altering or changing digital environments), evocation (i.e., unintentionally eliciting responses from digital environments), and application (i.e., integrating or applying experiences from digital environments). To conclude, we outline future directions for research that may clarify how identity development unfolds in the digital context.