bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tertiary lymphoid structures are associated with enhanced macrophage activation and immune checkpoint expression, and predict outcome in cervical cancer
Authors: Gorvel Laurent , Panouillot Marylou , Rouvière Marie-Sarah , Billon Emilien , Fattori Stéphane , Sonongbua Jumaporn , Boucherit Nicolas , Ben Amara Amira , Quilichini Olivia , Granjeaud Samuel , Degos Clara , Nunès Jacques A. , Carcopino Xavier , Lambaudie Eric , Chrétien Anne-Sophie , Sabatier Renaud , Dieu-Nosjean Marie-Caroline , Olive Daniel 
Published: January 2025

Abstract
Cervical tumors are usually treated using surgery, chemotherapy, and radiotherapy, and would benefit from immunotherapies. However, the immune microenvironment in cervical cancer remains poorly described. Tertiary lymphoid structures (TLS) were recently described as markers for better immunotherapy response and overall better prognosis in cancer patients. We evaluated the cervical tumor immune microenvironment, specifically focusing on TLS, using combined high-throughput phenotyping, soluble factor concentration dosage in the TME and spatial interaction analyses. We found that TLS presence was associated with a more inflammatory soluble microenvironment, with the presence of B cells as well as more activated macrophages and dendritic cells (DCs). Furthermore, this myeloid cell activation was associated with expression of immune checkpoints, such as PD-L1 and CD40, and proximity of activated conventional type 2 DCs (DC2) to CD8+ T cells, indicating better immune interactions and tumor control. Finally, we associated TLS presence, greater B cell density, and activated DC density with improved progression-free survival, substantiating TLS presence as a potential prognostic marker. Our results provide evidence that TLS presence denotes cell activation and immunotherapy target expression.
Biotic rather than abiotic factors influence ground-dwelling mygalomorph spider assemblages along an altitudinal gradient in the Brazilian semi-arid domain
Authors: Villanueva-Bonilla German Antonio , Azevedo Raul , Araújo Katherine Falcão , Lira André Felipe de Araújo , Sobczak Jober Fernando 
Published: January 2025

The species richness of organisms associated with altitudinal gradients tends to decline with increasing altitude, however, this pattern is not observed in mygalomorph. The present study tests the hypothesis that the richness and abundance of ground-dwelling mygalomorph spiders will be positively correlated with the increase in altitude, as well as will be influenced by variation of potential prey along an altitudinal gradient in the Brazilian semi-arid domain. Sampling took place during August 2020 to August 2021, through pitfall traps, totaling 50 traps/area/month. A total of 125 adult individuals belonging to 10 morphospecies were collected along the altitudinal gradient. Theraphosidae was the richest family in morphospecies, the most abundant mygalomorph was Neodiplotele caucaia Gonzalez-Filho, Lucas & Brescovit, 2015, Guyruita sp., and Diplura sanguinea (F.O. Pickard-Cambridge, 1896). Our results shows that mygalomorph abundance and species richness were affected by potential prey availability and not by altitude per se. Therefore, our results shows that the biotic (e.g., availability of potential preys) and no abiotic (e.g., elevation) may have a key factor to the mygalomorph spider assemblage modulation along an altitudinal gradient. The study opens precedents for further investigations on the distribution patterns of mygalomorph spiders in the Brazilian semiarid region.
The stream fish fauna of a pristine area in the South Amazon, rio Machado basin, Rondônia
Authors: Zdradek Dihon Leone , Tomaz Fabíola Silva , Ohara Willian Massaharu 
Published: January 2025

This study represents an inventory of fish collected in six small tributaries from the rio Tarumã river, in the Jaru Biological Reserve, middle rio Machado, Vale do Anari town, Rondônia, Brazil. The fieldwork was carried in August 2019 and 2021 in streams of up to third order during the low water period, in a 50 m blocked stretch located 1 km upstream of the mouth of the Tarumã river. The sampling effort in each stream was standardized with five people collecting with hand-nets and seine-nets for 2 hours. A total of 2.989 individuals, 64 species, 55 genera, 22 families and seven orders were captured. Seven species not identified at the species level belonging to the Cetopsorhamdia, Hemigrammus, Knodus, Microcharacidium, Paracanthopoma, Pyrrhulina, and Synbranchus, were considered as new. No exotic species was captured. The fish of the orders Characiformes and Siluriformes had the greatest abundance. Characidae was the family with greatest richness of captured species (13 species), being Hyphessobrycon agulha, Hemigrammus bellottii, Apistogramma resticulosa, and Elachocharax pulcher the species with the highest richness and abundance. This study illustrates the fish composition in a pristine area from the rio Machado and will serve as a baseline for future studies in view of the rapid replacement of forests in production systems of southern Amazonia.
Opening a New Chapter for Computational Linguistics
Authors: Lu Wei 
Published: January 2025

Abstract
By the end of 2024, the journal Computational Linguistics has reached a significant milestone: It has published exactly 50 volumes over the past half-century. As we launch the first issue of Volume 51, this is an opportune moment to reflect on the journal’s legacy, ongoing evolution, and the exciting changes that lie ahead. Together, we embark on a journey to open a new chapter for this storied publication.
Intracranial EEG referencing for large-scale category-selective mapping in the human ventral occipito-temporal cortex
Authors: Hagen Simen , Jacques Corentin , Ranta Radu , Koessler Laurent , Maillard Louis , Colnat-Coulbois Sophie , Rossion Bruno , Jonas Jacques 
Published: January 2025

Abstract
Intracranial EEG (iEEG) is increasingly used in many fields of human cognitive neuroscience since it offers a unique opportunity to directly record brain activity from awake humans at a high spatial and temporal resolution. However, little is known about the influence of the reference montage on the spatial and temporal characteristics of iEEG activity. Here, we compare the spatial and temporal profiles of neural activity for five reference montages (scalp reference, common average, zero reference, local Bipolar, and Laplacian) applied to a large dataset of depth electrodes (StereoElectroEncephaloGraphy, SEEG) recordings across the human ventral occipito-temporal cortex (VOTC, N individual brains = 77). Frequency-tagging is used for objective identification and quantification of both low- (&lt;30 Hz) and high-frequency (40–160 Hz) face-selective neural activity. For low-frequency responses, similar spatial distributions and time-courses of significant face-selective contacts and of face-selective amplitudes are found across the five reference montages, although the latter two local reference montages enhance face selectivity along the fusiform gyrus until the anterior temporal lobe. However, they also reduce the right hemisphere dominance, a hallmark of face-selective neural activity, and increase the number of significant contacts in the white matter. For high-frequency responses, similar spatial distributions and time-courses of significant face-selective contacts and of face-selective amplitudes are found for all references, except for the scalp reference (SCA), which enhances face selectivity in lateral and medial regions of the anterior VOTC. However, SCA also increases the number of significant contacts in the white matter. Thus, specificities of each electrode montage should be considered before choosing an iEEG reference, according to the research question, the anatomical region, the type of analyses, and the responses frequency range.
The effect of brain tissue anisotropy on the electric field caused by transcranial electric stimulation: Sensitivity analysis and magnetic resonance electrical impedance tomography
Authors: Mosayebi-Samani Mohsen , Cunha Teresa , Eroğlu Hasan Hüseyin , Siebner Hartwig Roman , Nitsche Michael A. , Thielscher Axel 
Published: January 2025

Abstract
Calculations of the electric field (E-field) are important for addressing the variability in the physical dose of transcranial electric stimulation (tES). These calculations rely on precise knowledge of the individual head and brain anatomy and on choosing the appropriate ohmic conductivities for the different tissue compartments. In particular, the conductivity of brain white matter and to a lesser extent gray matter is anisotropic. Consensus on the importance to account for the conductivity anisotropy of the brain in the E-field calculations is still lacking. Most simulation studies use isotropic conductivities, which avoids the need for diffusion tensor imaging (DTI) data and lowers practical complexity. On the other hand, in magnetic resonance electrical impedance tomography (MREIT) that employs measurements of the tiny magnetic fields caused by the tES-induced current flow, diffusion anisotropy measured by DTI has been put forward as a key parameter for the reconstruction of the brain conductivity at the individual level. Here, we conducted a series of three sub-studies to systematically assess the effect of brain anisotropy on the tES-induced E-field in cortical gray matter and to compare in-vivo MREIT data with simulated data from isotropic and anisotropic head models. In sub-study 1, we employed simulations to demonstrate that sparse knowledge of the ohmic tissue conductivities is the main source of uncertainty, while the modeling of brain anisotropy has comparatively small effects on the simulated E-field. In sub-study 2, we compared simulations with in-vivo MREIT data and found that optimizing the conductivities of the modeled tissue compartments enhanced the agreement between simulated and measured data. Modeling brain conductivity as anisotropic had no impact on this optimization process. In sub-study 3, we used simulations to test how the differences in the tES-induced current flow caused by isotropic versus anisotropic brain conductivities affect the results of the “DT-MREIT” algorithm, which enables voxel-wise reconstructions of brain tissue conductivity. The algorithm performed similarly in both cases. On the other hand, the results were worse in a more realistic scenario where the reconstruction was based on simulated MREIT data (rather than simulated current densities). Together, our findings underscore the relevance of an accurate knowledge of the tissue conductivities for calculations of the tES-induced E-field. When cortical gray matter is the target for tES, modeling brain conductivity as anisotropic based on DTI data does not add substantial benefit. While in-vivo MREIT data generally show promise for refining the conductivity estimates of biological tissue at low frequencies, MREIT appears to be only weakly sensitive to the conductivity anisotropy of brain tissue.
Learning in Interactive Decision-Making: The Interplay Between Cognitive Abilities and the Strategic Environment
Authors: Zonca Joshua , Del Mauro Lilia , Rustichini Aldo , Polonio Luca , Reverberi Carlo 
Published: January 2025

Abstract
A remarkable feature of human intelligence is the ability to optimize our decisions based on the potential actions of others. This ability, i.e., strategic sophistication, is crucial in strategic interactions, where we need to predict others’ actions (first-order beliefs), anticipate others’ beliefs about our own possible actions (second-order beliefs), and optimize decisions based on such beliefs. While behavioral research has highlighted systematic departures from theoretically optimal behavior in strategic interactions, little is known about the possibility of enhancing strategic sophistication. In particular, no studies investigated whether and how the interaction between exogenous factors (i.e., the learning environment) and endogenous factors (i.e., individual cognitive abilities) shapes learning in strategic settings. In a novel mouse-tracking study, we manipulate the learning environment and test its interaction with individual cognitive abilities in determining context-specific and transfer of learning in interactive games. Choice and process data reveal that the interplay between individual cognitive abilities and the learning environment does modulate participants’ learning. The learning environment determines what is learned and whether acquired knowledge is applied in similar contexts and transferred to novel settings. Moreover, learning success in different strategic environments depends on individual cognitive abilities. In particular, higher levels of cognitive reflection are necessary to learn sophisticated strategic behavior (i.e., forming second-order beliefs) and transfer acquired knowledge to more complex strategic environments after receiving relevant feedback. However, higher cognitive reflection levels are insufficient to prevent the misapplication of procedures learned in a specific environment to other strategic contexts with substantial structural differences. Our results provide novel insights into the factors that promote or hamper learning in interactive decision-making.
Some Arab and Muslim Names Discernible in Maltese Toponymy
Authors: Cassar Mario 
Published: January 2025

This chapter explores the influence of Arabic and Muslim personal names on Maltese toponymy, emphasizing their prevalence and significance in the linguistic and cultural history of the Maltese Islands. Maltese toponyms of Arabic origin exhibit a wealth of anthroponymic and descriptive elements, revealing a deep interconnection between language and geography. Names are categorized based on semantic distinctions, with many derived from Arabic personal names, including secular, religious, and theophoric types. Examples include names referencing physical characteristics, professions, or associations with Islamic religious traditions, such as Jabbār (“powerful”) and ʿAbd Allāh (“servant of Allah”).
The study distinguishes between macro- and microtoponyms, noting that most examples fall within the latter category, and discusses classification methods, including single-word and compound toponyms. Key thematic categories include hydronyms, oronyms, agronyms, and names associated with man-made structures or religious sites. The chapter also addresses linguistic phenomena such as morphological transformations, phonetic adaptations, and folk etymology, which have shaped the evolution of these place names over centuries.
With approximately 170 Arabic-derived names identified, this study provides a comprehensive inventory while acknowledging its limitations and the potential for future research to uncover more examples. By analyzing these toponyms, the chapter highlights the enduring legacy of Arabic language and culture in Maltese history, providing valuable insights into the region’s rich linguistic heritage and the interconnectedness of language, identity, and geography.
The Temporal and Financial Costs of Trauma Activation Wait Times
Authors: Mattison Erik G. , Cucher Daniel J. , Kovacs Melissa S. , Tiffany Brian R. , Hu Charles K. 
Published: January 2025

Background Level 1 Trauma Centers alert hospital staff in advance of a trauma patient’s arrival to allow time for trauma team assembly and preparedness. Excess staff wait times may result in reduced trauma center productivity and efficiency. The objective of this study was to explore the wait time expended by various hospital staff in anticipation of trauma patient arrivals and calculate cost and adequacy of preparation time. Methods This prospective observational study recorded a sample of wait times for trauma team staff members at an urban Level 1 Trauma Center for 12 months. We observed 288 trauma activations in total. We constructed a dataset of notification alerts, patient arrival times, staff arrival, and wait times, along with a qualitative staff assessment of time to prepare for the trauma patient’s arrival. We applied detailed salary data to quantify the financial cost of Trauma Center staff wait time. Results When staff waited for a trauma patient’s arrival, average wait times ranged from 4.27 to 10.67 minutes. This cost $139 791.65 during calendar year 2023 at our hospital. Staff had enough time to arrive at trauma incidents 99.1% of the time. In 4.2% of cases (n = 12), staff had no advance notification of an incoming trauma patient. Discussion We find that a longer duration between the issuance of alerts and the actual arrival of trauma patients represents a direct financial cost attributable to lost productivity in addition to indirect and cascading effects on operational efficiency and patient care.
Kinetic estimated glomerular filtration rate and drug dosing in critically ill patients with acute kidney injury—A prospective observational study
Authors: Dinakar Divya , Chandan Garud , Sreedhara Rajanna , Parekh Aashish , Aryamparambil Padmakumar , Sarada Pooja ikPrathapan , KM Ganesh 
Published: January 2025

Objective To study the impact of kinetic glomerular filtration rate (kGFR) on clinical decision making and its implications on drug dosing compared to that of estimated GFR (eGFR) using chronic kidney disease epidemiology collaboration (CKD-EPI) equation in critically ill patients with acute kidney injury (AKI) admitted in a tertiary level intensive care unit (ICU). Methods Cross-sectional, prospective, observational study design. All patients admitted to Medical ICU, Fortis Hospital, Bangalore with AKI defined as per AKI network (AKIN) criteria. Patients were recruited after approval from the scientific and institutional ethics committee, with written informed consent. Serum creatinine values at admission and further values were noted. GFR was calculated using both formulas (CKD-EPI and kGFR) and documented at all intervals of creatinine sampling. Drugs requiring renal dose modification along with the dosing were documented. Sample size was calculated after a pilot study and a total of 107 patients were analyzed. Results Incidence of AKI was 12.84%. The mean (±SD) eGFR was 37.25 (±29.4) and kGFR was 42.5 (±33.2), ( p-value .003). 70 (65.42%) patients required drug dose change when kGFR was used. Dosing changes from Day 1 to Day 5 are 53/104 (50.9%), 39/81 (48.1%), 12/26 (46.1%), 2/9 (28.5%), 1/2 (50%). Predominant dose changes were for antimicrobials: vancomycin (35.7%), acyclovir (23.1%), and meropenem (23%). Discussion Drug dosing using different methods of GFR calculation showed a difference in the dosing in 65.42% of patients with AKI. Accounting for change in creatinine over time using kinetic GFR may lead to better drug dosing in critically ill patients with AKI. Conclusion Our study shows that calculating GFR using kGFR formula instead of CKD-EPI may change drug dosages among patients with AKI admitted in ICU. By replacing conventional GFR estimation formulas with kGFR we may reduce the drug dosing inaccuracies that are currently prevalent in this cohort of patients.
Computational analysis and optimization of foam-filled honeycomb core sandwich structure under air blast loading
Authors: Sahoo Satya Sundar , Swain Abinash Kumar , Sawant Vishwas A 
Published: January 2025

Developing a sandwich structure with a lightweight and high energy absorption capacity is crucial to mitigating shock waves when subjected to blast loading. In this present study, a novel double-core hexagonal sandwich structure filled with aluminum (Al) foam is used to investigate the structural response under blast loading subjected to 1 to 3 kg of charge of TNT kept at a stand-off distance (SoD) of 100 mm. The investigation and its assessment are mainly focused on the deflection of the face sheets and the energy absorption capacity of the panel. The Johnson-Cook plasticity model and crushable foam hardening are used in stainless steel and Al foam, respectively, to examine the performance under blast loading. The conventional weapons effect programme (ConWep) method is employed for numerical modeling and blast load analysis. Subsequently, a comparison is made between the blast resistance of the double-core sandwich structure and that of the experimental results of the single-core sandwich structure obtained from previous literature. Further, to improve the performance of the developed double-core sandwich structure, an optimization study is conducted using the genetic algorithm (GA) and the non-dominated sorted genetic algorithm II (NSGA-II) to explore single- and multi-objective problems, respectively. The results showed that for the single-objective optimization, the maximum back facesheet deflection is reduced by 13.35% at constant mass compared to the initial design, while for the multi-objective optimization, five optimal design values are obtained from the Pareto front and can be seen as a potential replacement for single-core panels. The novel structure developed in this study will be used in defense, automotive, and aerospace applications.
Current utility, instruments, and future directions for intra-renal pressure management during ureteroscopy: scoping review by global research in intra-renal pressure collaborative group initiative
Authors: Yuen Steffi Kar Kei , Zhong Wen , Chan Yun Sang , Castellani Daniele , Bhojani Naeem , Agarwal Madhu Sudan , Tokas Theodoros , Croghan Stefanie , Jung Helene , Herrmann Thomas , Somani Bhaskar , Gauhar Vineet ,   The Global Research on Intra-renal Pressure Collaborative Group
Published: January 2025

Background: Technical advancements and intrarenal pressure are synergistic in improving perioperative outcomes during flexible ureteroscopy (FURS). Mismanaged intra-renal pressure (IRP) has negative consequences and it is associated with an increased risk of sepsis, bleeding, pelvicalyceal fluid extravasation, and even collecting system injuries and acute as well as chronic renal failure. The cornerstone of a safe FURS is the ability to continuously monitor IRP to avoid elevation of IRP above the normal range of 10 mmHg. Objectives: This scoping review aims to report the current state of real-time IRP monitoring in in vivo clinical studies and the various monitoring methods and technology to understand how this may be best used in daily clinical practice. Eligibility criteria: A systematic literature search was conducted. Only in vivo clinical studies published in English documenting IRP measurement methodologies during semirigid or flexible ureteroscopy for urolithiasis management were included. Results: Out of 1326 retrieved papers, 17 studies met the inclusion criteria, comprising 2 randomized controlled trials, 2 retrospective studies, and 13 observational studies. Current noninvasive IRP monitoring devices include ureteric catheters placed retrogradely or via percutaneous tubing and connected to pressure transducers, amplified by cardiology-used pressure sensing systems or urodynamic systems, automated pressure-regulating systems, pressure sensing guidewires, and IRP sensing flexible ureteroscopes. The review revealed significant variations in IRP measurement methods, reporting units, and irrigation techniques. Notably, elevated IRP above 30 mmHg was consistently associated with increased postoperative complications, including sepsis. Conclusion: Current clinical studies have only ascertained that increased IRP above 40 mmHg positively correlates with infectious complications and postoperative pain. No standardized values are available to predefine safe thresholds in practice. With the availability of noninvasive tools for IRP monitoring, future research should focus on multicenter studies to establish reference ranges and best practices for IRP management, ultimately improving patient outcomes in endourological procedures.