bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two resected cases of benign adenomyoepithelioma
Authors: Fukudome Yurika , Nagata Yoshika , Yamada Yui , Saeki Toshihiro , Fujikawa Takahisa 
Published: December 2023

Abstract
Background
Adenomyoepithelioma (AME) of the breast is an uncommon tumor characterized by the proliferation of ductal epithelial and myoepithelial cells with the heterogeneity. Although benign AME is relatively easy to differentiate from breast cancer by core needle biopsy (CNB) alone, a definitive diagnosis is often difficult. The imaging findings of AME are also variable, and there are particularly few reports about radiological features, including contrast-enhanced magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) values in AME.

Case presentation
We present two cases of benign AME. Case 1 is a 30-year-old woman with a history of asthma. The cystic tumor shows smooth borders, and the intracystic solid component is irregular in shape and high vascularity. The pathological findings of the tumor were benign on CNB. The MRI scan showed a decreased ADC value. Case 2 is a 60-year-old woman with only a history of arrhythmia. The tumor shows a lobulated mass with cystic space and coarse calcifications. The pathological findings of the tumor were found to be benign by CNB. Dynamic MRI scan showed a fast washout pattern with a decreased ADC value. Both patients underwent excisional biopsy to confirm the diagnosis, and the pathological diagnosis was benign AME in both cases.

Conclusions
The AME of the breast has little specific imaging information, so it can be difficult to diagnose based on pathological findings of biopsy specimen. In our case, the ADC values were exceptionally low, contrary to previous reports. It is essential to carefully diagnose AME, considering the discrepancies in imaging findings observed in this case.
Penile fracture with urethral injury: a case report of rare double trouble
Authors: Hameed Farooq , Anwaar Adeel , Saeed Humayun , Noor Usman , Saleem Abdullah , Anwar Mamoona 
Published: December 2023

Abstract
Background
A penile fracture occurs when the tunica albuginea of penis tears during erection. Penile fracture is a rare but serious injury that occurs when the erect penis sustains a traumatic force. It is characterized by a sudden snapping or popping sound, followed by immediate pain, swelling, and discoloration. Its association with concomitant urethral injury is very rare. This case study describes such a rare case.

Case presentation
In this case study, we present the case of a 47-year-old man who experienced sudden pain and lost erection with a popping sound while having sexual intercourse. There was bloody discharge from the urethral opening and showed the distinct sign of an "Eggplant Deformity." This result confirmed the diagnosis. Immediate surgical intervention revealed damage to the left corpora and urethra. The procedure involved repairing the tunica albuginea covering the corpora tissue and reconstructing the damaged urethra. The surgery went smoothly without complications. The patient reported satisfactory erectile function and normal urination on follow-up visit after 2 months.

Conclusion
Penile fracture with urethral injury is a rare but serious emergency. Prompt detection and surgical intervention are crucial for optimal outcomes and minimal complications. Depending on severity, either catheterization or repair may be necessary.
Sub-50-fs Kerr-lens mode-locked Yb-doped fluoride laser with 44% optical efficiency
Authors: Su Xiancui , Wang Yiran , Su Liangbi , Liu Shande , Zheng Lihe , Zhang Bingyuan , He Jingliang , Zhang Baitao 
Published: December 2023

Yb-doped fluoride has been demonstrated to be potential crystals for application in efficient ultrafast lasers. However, the trade-off between the shorter pulses with higher efficiencies is a challenge. In this work, using Yb,Gd:CaSrF2 crystal, we report on a sub-50-fs Kerr-lens mode-locked oscillator with an optical efficiency up to 44%. Pumped by a 976-nm diffraction-limited fiber laser and using chirped mirrors combined with prism pairs for the dispersion compensation, a pulse as short as 46 fs was obtained with 620-mW output power, corresponding to an optical efficiency more than 40%. Stable Kerr-lens mode-locking with RMS of output power lower than 0.3% and beam quality factors M2<1.14 were achieved. Moreover, a maximum output power of 780 mW was obtained in continuous-wave operation with 55.3% optical efficiency. To the best of our knowledge, the results in this work represent the shortest pulses generated from Yb-doped fluoride lasers as well as the highest optical efficiencies ever reported in sub-100 fs Yb bulk lasers.
Knockdown of TPI in human dermal microvascular endothelial cells and its impact on angiogenesis in vitro
Authors: Herre Christina , Nshdejan Arpenik , Klopfleisch Robert , Corte Giuliano Mario , Bahramsoltani Mahtab 
Published: December 2023

Introduction
Angiogenic behaviour has been shown as highly versatile among Endothelial cells (ECs) causing problems of in vitro assays of angiogenesis considering their reproducibility. It is indispensable to investigate influencing factors of the angiogenic potency of ECs.

Objective
The present study aimed to analyse the impact of knocking down triosephosphate isomerase (TPI) on in vitro angiogenesis and simultaneously on vimentin (VIM) and adenosylmethionine synthetase isoform type 2 (MAT2A) expression. Furthermore, native expression profiles of TPI, VIM and MAT2A in the course of angiogenesis in vitro were examined.

Methods
Two batches of human dermal microvascular ECs were cultivated over 50 days and stimulated to undergo angiogenesis. A shRNA-mediated knockdown of TPI was performed. During cultivation, time-dependant morphological changes were detected and applied for EC-staging as prerequisite for quantifying in vitro angiogenesis. Additionally, mRNA and protein levels of all proteins were monitored.

Results
Opposed to native cells, knockdown cells were not able to enter late stages of angiogenesis and primarily displayed a downregulation of VIM and an uprise in MAT2A expression. Native cells increased their TPI expression and decreased their VIM expression during the course of angiogenesis in vitro. For MAT2A, highest expression was observed to be in the beginning and at the end of angiogenesis.

Conclusion
Knocking down TPI provoked expressional changes in VIM and MAT2A and a deceleration of in vitro angiogenesis, indicating that TPI represents an angiogenic protein. Native expression profiles lead to the assumption of VIM being predominantly relevant in beginning stages, MAT2A in beginning and late stages and TPI during the whole course of angiogenesis in vitro.
Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan
Authors: Munir Ayesha , Khan Suleman , Khan Sanaullah , Attaullah Sobia , Munir Mehwish , Saleem Aisha , Ali Ijaz 
Published: December 2023

Background
Rheumatoid arthritis (RA) is an immune-mediated, polyarthritis linked with various genetic and environmental causative agents. Among environmental triggers, Epstein-Barr Virus (EBV) is considered the most potent etiological agent.

Objective
This study aimed to investigate the prevalence of EBV and its genotypes in RA patients and to investigate their association with clinical and laboratory parameters of RA.

Methodology
This study included blood samples of RA and control healthy individuals (100 each). Blood samples along with clinical and laboratory parameters were collected from patients after consent in the Department of Rheumatology, at Lady Reading Hospital, in Peshawar Pakistan. Blood samples were processed for DNA extraction followed by PCR amplification for EBV detection and genotype discrimination.

Results
RA patients were 85 females and 15 males with a mean age of 40.13±14.05 years. EBV Type-1 was detected in 45% of RA and 9% of control cases. The mean disease duration of RA patients was 6.61±6.23 years. Out of 100 diseased patients, 43% were seropositive rheumatoid arthritis (SPRA) and showed a significant correlation with a family history of RA in EBV-positive individuals (P = 0.017). The demographic, clinical, and laboratory parameters of RA patients showed a non-significant association with EBV. Moreover, only a family history and Serum creatinine of RA patients showed a significant association with EBV (P = 0.0001 and P = 0.022 respectively).

Conclusion
It is concluded that EBV-1 is prevalent and associated with RA. Further investigation is required for detailed genetic analysis of EBV to determine its possible role in modulating the immune system in RA.
Association between use of antihypertensives and cognitive decline in the elderly—A retrospective observational study
Authors: Dhami Prabhpaul , Alagiakrishnan Kannayiram , Senthilselvan Ambikaipakan 
Published: December 2023

Aim
Mild cognitive impairment (MCI) is the prodromal phase of dementia. The objective of this study was to determine whether specific antihypertensives were associated with conversion from MCI to dementia.

Methods
In this retrospective study, a chart review was conducted on 335 older adults seen at the University of Alberta Hospital, Kaye Edmonton Seniors Clinic who were diagnosed with MCI. At the point of diagnosis, data was collected on demographic and lifestyle characteristics, measures of cognitive function, blood pressure measurements, use of antihypertensives, and other known or suspected risk factors for cognitive decline. Patients were followed for 5.5 years for dementia diagnoses. A logistic regression analysis was then conducted to determine the factors associated with conversion from MCI to dementia.

Results
Mean age (± standard deviation) of the study participants was 76.5 ± 7.3 years. Patients who converted from MCI to dementia were significantly older and were more likely to have a family history of dementia. After controlling for potential confounders including age, sex, Mini Mental Status Exam scores and family history of dementia, patients who were on beta-blockers (BBs) had a 57% reduction in the odds of converting to dementia (OR: 0.43, 95% CI: 0.23, 0.81).

Conclusions
In this study, BB use was protective against conversion from MCI to dementia. Further studies are required to confirm the findings of our study and to elucidate the effect of BBs on cognitive decline.
Predicting child development and school readiness, at age 5, for Aboriginal and non-Aboriginal children in Australia’s Northern Territory
Authors: Dadi Abel Fekadu , He Vincent , Nutton Georgina , Su Jiunn-Yih , Guthridge Steven 
Published: December 2023

Background
Positive early development is critical in shaping children’s lifelong health and wellbeing. Identifying children at risk of poor development is important in targeting early interventions to children and families most in need of support. We aimed to develop a predictive model that could inform early support for vulnerable children.

Methods
We analysed linked administrative records for a birth cohort of 2,380 Northern Territory children (including 1,222 Aboriginal children) who were in their first year of school in 2015 and had a completed record from the Australian Early Development Census (AEDC). The AEDC measures early child development (school readiness) across five domains of development. We fitted prediction models, for AEDC weighted summary scores, using a Partial Least Square Structural Equation Model (PLS-SEM) considering four groups of factors–pre-pregnancy, pregnancy, known at birth, and child-related factors. We first assessed the models’ internal validity and then the out-of-sample predictive power (external validity) using the PLSpredict procedure.

Result
We identified separate predictive models, with a good fit, for Aboriginal and non-Aboriginal children. For Aboriginal children, a significant pre-pregnancy predictor of better outcomes was higher socioeconomic status (direct, β = 0.22 and indirect, β = 0.16). Pregnancy factors (gestational diabetes and maternal smoking (indirect, β = -0.09) and child-related factors (English as a second language and not attending preschool (direct, β = -0.28) predicted poorer outcomes. Further, pregnancy and child-related factors partially mediated the effects of pre-pregnancy factors; and child-related factors fully mediated the effects of pregnancy factors on AEDC weighted scores. For non-Aboriginal children, pre-pregnancy factors (increasing maternal age, socioeconomic status, parity, and occupation of the primary carer) directly predicted better outcomes (β = 0.29). A technical observation was that variance in AEDC weighted scores was not equally captured across all five AEDC domains; for Aboriginal children results were based on only three domains (emotional maturity; social competence, and language and cognitive skills (school-based)) and for non-Aboriginal children, on a single domain (language and cognitive skills (school-based)).

Conclusion
The models give insight into the interplay of multiple factors at different stages of a child’s development and inform service and policy responses. Recruiting children and their families for early support programs should consider both the direct effects of the predictors and their interactions. The content and application of the AEDC measurement need to be strengthened to ensure all domains of a child’s development are captured equally.
Intercooperación e integración financiera como modelo de innovación social: El caso de COOPCENTRAL
Authors: PEREZ COLOMBIA , Rua Castañeda Sohely , Varón Rico John 
Published: December 2023

Objetivo: En el texto se presenta un análisis interpretativo del fenómeno de la intercooperación y la integración cooperativa y solidaria en el contexto del sector financiero, a partir del caso de la Red Coopcentral en Colombia. Método: Este es un estudio de caso único orientado a una generalización analítica para comprender procesos en desarrollo en contextos específicos. Su implementación incluyó entrevistas en profundidad y revisión documental. Resultados: Se observó que la integración económica entre cooperativas implica por lo menos dos aspectos: la cultura para la asociatividad y el desarrollo de estructuras organizacionales que van desde la toma de decisiones hasta lo operativo. Discusiones: Se derivan de este análisis lecciones aprendidas, retos y desafíos que permiten aportar elementos para construir teoría acerca de la integración y la intercooperación, ya que muestra niveles complementarios de formalización y se consolida en un proceso de larga duración en permanente cambio, para responder a los desafíos del contexto; lo cual hace que no sea un hecho puntual o coyuntural sino un objetivo estratégico de las organizaciones del sector financiero solidario. Conclusiones: la intercooperación y la integración permiten la consolidación empresarial de las organizaciones cooperativas, incorporando enfoques de redes de trabajo colaborativo, integración horizontal y toma de decisiones democráticas. Esto significa que la cooperación se transforma en capacidad de gestión y se traduce en mayores beneficios para los asociados, aunque es evidente que la organización afronta permanentes desafíos para mantener un equilibrio dinámico entre la lógica empresarial y la lógica social inherente al modelo de integración.
Economía Social y Solidaria en tiempos de pandemia
Authors: Gómez Núñez Nicolás , Reyes Espejo María Isabel , González Torrealba Matías , Salinas Valdés Nicolás 
Published: December 2023

Este documento presenta los elementos básicos de las representaciones sobre los artefactos de prevención y las prácticas de acompañamiento, elaboradas por las organizaciones que produjeron bienes y servicios en tiempos de COVID19, en las comunas de Valparaíso y San Bernardo en Chile; y se describen las redes de reciprocidad donde existieron esas representaciones.
El marco conceptual estuvo formado por las categorías de colectivo, tecnología social y régimen de vitalidad, los cuales también son considerados como referentes empíricos para observar la gestión de recursos en el sector económico social y solidario.
El diseño del estudio fue cualitativo, para este artículo se trabajó con dos de los seis casos; las técnicas usadas fueron: la observación y la conversación; como herramientas se usó: la pauta de observación de documento y la entrevista; y el análisis de datos fue guiado por la comparación constante de casos por similitudes, basado en el análisis estructural del discurso y en el análisis estructural de redes.
Uno de los principales resultados fue que existieron circuitos de reciprocidad intersectorial que facilitaron la generación de mercados donde las cosas tuvieron valor de uso, estas interacciones están guiadas por una representación elemental, donde el “territorio” es parte de la evocación de la comunidad que “trabaja” como práctica de “resistencia”. Y la conclusión es que, en tiempos de pandemia se desprivatizan la vida y la muerte, lo cual contribuye a situar a las tecnologías sociales elaboradas por los colectivos, en un nivel semántico de trascendencia.
Diabetic state of human coronary artery endothelial cells results in altered effects of bone mesenchymal stem cell‐derived extracellular vesicles
Authors: Xu Cynthia M. , Karbasiafshar Catherine , Brinck‐Teixeira Rayane , Broadwin Mark , Sellke Frank W. , Abid M. Ruhul 
Published: December 2023

AbstractHuman bone mesenchymal stem cell‐derived extracellular vesicles (HBMSC‐EV) have been used successfully in animal models of myocardial ischemia, yet have dampened effects in metabolic syndrome through unknown mechanisms. This study demonstrates the basal differences between non‐diabetic human coronary artery endothelial cells (HCAEC) and diabetic HCAEC (DM‐HCAEC), and how these cells respond to the treatment of HBMSC‐EV. HCAEC and DM‐HCAEC were treated with HBMSC‐EV for 6 h. Proteomics, western blot analysis, and tube formation assays were performed. Key metabolic, growth, and stress/starvation cellular responses were significantly altered in DM‐HCAEC in comparison to that of HCAEC at baseline. Proteomics demonstrated increased phosphorus metabolic process and immune pathways and decreased RNA processing and biosynthetic pathways in DM‐HCAEC. Similar to previous in vivo findings, HCAEC responded to the HBMSC‐EV with regenerative and anti‐inflammatory effects through the upregulation of multiple RNA pathways and downregulation of immune cell activation pathways. In contrast, DM‐HCAEC had a significantly diminished response to HBMSC‐EV, likely due to the baseline abnormalities in DM‐HCAEC. To achieve the full benefits of HBMSC‐EV and for a successful transition of this potential therapeutic agent to clinical studies, the abnormalities found in DM‐HCAEC will need to be further studied.
Effects of skin and mild core cooling on cognitive function in cold air in men
Authors: Wallace Phillip J. , Gagnon Dominique D. , Hartley Geoffrey L. , Taber Michael J. , Cheung Stephen S. 
Published: December 2023

AbstractThis study tested the effects of skin and core cooling on cognitive function in 0°C cold air. Ten males completed a randomized, repeated measures study consisting of four environmental conditions: (i) 30 min of exposure to 22°C thermoneutral air (TN), (ii) 15 min to 0°C cold air which cooled skin temperature to ~27°C (CS), (iii) 0°C cold air exposure causing mild core cooling of ∆‐0.3°C from baseline (C‐0.3°C) and (iv) 0°C cold air exposure causing mild core cooling of ∆‐0.8°C from baseline (C‐0.8°C). Cognitive function (reaction time [ms] and errors made [#]) were tested using a simple reaction test, a two–six item working memory capacity task, and vertical flanker task to assess executive function. There were no condition effects (all p > 0.05) for number of errors made on any task. There were no significant differences in reaction time relative to TN for the vertical flanker and item working memory capacity task. However, simple reaction time was slower in C‐0.3°C (297 ± 33 ms) and C‐0.8°C (296 ± 41 ms) compared to CS (267 ± 26 ms) but not TN (274 ± 38). Despite small changes in simple reaction time (~30 ms), executive function and working memory was maintained in 0°C cold air with up to ∆‐0.8°C reduction in core temperature.
Low-illumination image enhancement with logarithmic tone mapping
Authors: Du Changqing , Li Jingjian , Yuan Bin 
Published: December 2023

Abstract
For low-illumination video sequences, some existing enhancement algorithms have some problems, such as image over-enhancement, color distortion, and inadequate detail processing. Based on luminance detection, we add logarithmic tone mapping to optimize the existing algorithms. The color space of low-illumination video image is converted from the red, green, blue mode to the hue-saturation-intensity mode, and then, logarithmic tone enhancement is applied to the image. Algorithm in this study has an obvious effect on image luminance enhancement and details processing, which makes the low-illumination video show a clear image with more natural visual effect, thus improving the quality of low-illumination video. This algorithm can avoid the problems of overexposure, color distortion, and blurring of detail processing under low illumination. The infrared spectrum of the object can be captured by infrared detection equipment, and the purpose of image enhancement can be achieved by applying the infrared spectrum of the object.
Correlation between serum vitamin D level and uterine volume in girls with idiopathic central precocious puberty
Authors: Sun Jun , Wang Wei , Xiao Ya , Cao Niu-niu , Wang Yi-fan , Zhang Hong-ru , Jiang Shu-qin 
Published: December 2023

Abstract

Objectives
Investigate serum vitamin D (vit D) levels’ relation to uterine volume in idiopathic central precocious puberty (ICPP) girls and compare findings with normal peers.

Methods
Analyzed 278 ICPP cases from January 2017 to September 2022 alongside 239 normally developing girls. Collected clinical data and lab markers and performed subgroup analysis based on vit D levels. Correlation and regression analyses were conducted.

Results
The ICPP group exhibited elevated uterine volume and lower serum vit D compared to controls (p<0.05). A weak negative correlation was noted between vit D and uterine volume in ICPP (r=−0.193, p=0.004), and no such correlation in controls (r=−0.073, p=0.319). The ICPP vit D deficiency subgroup displayed higher uterine volume than the insufficiency and sufficiency subgroups (p<0.05). Uterine volume in the insufficiency subgroup exceeded the sufficiency subgroup (p<0.05). After adjusting for confounders, lower vit D is linked to increased ICPP uterine volume (non-standardized regression coefficient β=−25.55, 95 % CI= −46.23, −4.87, p=0.016). A Limited correlation between vit D and uterine volume was seen in girls with normal pubertal timing.

Conclusions
We demonstrated a correlation between vit D and uterine volume in ICPP girls, absent in normal peers. ICPP girls often exhibit lower vit D levels and increased uterine volume. Further research is vital for understanding vit D’s role in ICPP pathogenesis and guiding prevention and treatment strategies.