bluuebunny/crossref_metadata_2025_split huggingface dataset:
LightRoseTTA: High-efficient and Accurate Protein Structure Prediction Using an Ultra-Lightweight Deep Graph Model
Authors: Wang Xudong , Zhang Tong , Liu Guangbu , Cui Zhen , Zeng Zhiyong , Long Cheng , Zheng Wenming , Yang Jian 
Published: November 2023

AbstractAccurately predicting protein structure, from amino acid sequences to three-dimensional structures, is of great significance in biological research. To tackle this issue, a representative deep big model, RoseTTAFold, has been proposed with promising success. Here, we reportan ultra-lightweight deep graph network, namedLightRoseTTA, to achieve accurate and high-efficient prediction for proteins. Notably, three highlights are possessed by our LightRoseTTA:(i) high-accuratestructure prediction for proteins, beingcompetitive with RoseTTAFoldon multiple popular datasets including CASP14 and CAMEO;(ii) high-efficienttraining and inference with an ultra-lightweight model, costingonly one week on one single general NVIDIA 3090 GPU for model-training(vs 30 days on 8 high-speed NVIDIA V100 GPUs for RoseTTAFold) and containingonly 1.4M parameters(vs 130M in RoseTTAFold);(iii) low dependencyon multi-sequence alignments (MSA, widely-used homologous information), achievingthe best performance on three MSA-insufficient datasets: Orphan, De novo, and Orphan25. Besides, our LightRoseTTA istransferablefrom general proteins to antibody data, as verified in our experiments. We visualize some case studies to demonstrate the high-quality prediction, and provide some insights on how the structure predictions facilitate the understanding of biological functions. We further make a discussion on the time and resource costs of LightRoseTTA and RoseTTAFold, and demonstrate the feasibility of lightweight models for protein structure prediction, which may be crucial in the resource-limited research for universities and academy institutions.We release our code and model to speed biological research.
From the Wild to the City: How Domestication and Urbanization Reshape Animal Gut Microbiome
Authors: Das Angsuman , Das Bhabana , Das Jyotishmita 
Published: November 2023

AbstractThis review explores the profound effects of domestication and urbanization on the gut microbiota of animals. It delves into the complex interplay between these two processes and their transformative impact on the microorganisms residing in the gastrointestinal tracts of a wide range of species. Domestication, the centuries-old practice of taming and breeding animals for human use, has led to significant shifts in the gut microbiomes of domesticated animals. This shift is a result of altered diets, living conditions, and reduced exposure to natural environments. The paper examines the consequences of these changes on animal health, behavior, and their adaptation to domestic life. Conversely, urbanization, characterized by the rapid expansion of cities and human habitats, has driven wild animals to adapt to urban environments. This review investigates how the urban landscape, pollution, and dietary changes reshape the gut microbiomes of urban wildlife. It explores the potential implications of these alterations on the animals’ resilience to urban stressors and disease. Drawing parallels between domestication and urbanization, the paper reveals intriguing similarities and differences in gut microbiome transformations across various species. It also assesses the broader implications of these shifts on ecological dynamics, zoonotic disease transmission, and the potential for microbial interactions between domesticated animals, urban wildlife, and humans. Ultimately, this review consolidates current knowledge on the topic, shedding light on the shared mechanisms and unique adaptations that drive microbial changes in animals undergoing domestication and those adapting to urban environments. It concludes with a discussion of the implications for animal conservation, animal-human interactions, and the One Health perspective, emphasizing the importance of understanding these intricate icrobial relationships in our ever-changing world. By enhancing our comprehension of these complex dynamics, this paper contributes to the growing body of knowledge that informs our coexistence with the animals we share our lives and cities with, highlighting the critical role of gut microbiota in these processes.
Development and Characterization of a low intensity vibrational system for microgravity studies
Authors: Khan Omor M. , Gasperini Will , Necessary Chess , Jacobs Zach , Perry Sam , Rexroat Jason , Nelson Kendall , Gamble Paul , Clements Twyman , DeLeon Maximilien , Howard Sean , Zavala Anamaria , Farach-Carson Mary , Blaber Elizabeth , Wu Danielle , Satici Aykut , Uzer Gunes 
Published: November 2023

AbstractThe advent of extended-duration human spaceflight demands a better comprehension of the physiological impacts of microgravity. One primary concern is the adverse impact on the musculoskeletal system, including muscle atrophy and bone density reduction. Ground-based microgravity simulations have provided insights, with vibrational bioreactors emerging as potential mitigators of these negative effects. Despite the potential they have, the adaptation of vibrational bioreactors for space remains unfulfilled, resulting in a significant gap in microgravity research. This paper introduces the first automated low-intensity vibrational (LIV) bioreactor designed specifically for the International Space Station (ISS) environment. Our research covers the bioreactor’s design and characterization, the selection of an optimal linear guide for consistent 1-axis acceleration, a thorough analysis of its thermal and diffusion dynamics, and the pioneering use of BioMed Clear resin for enhanced scaffold design. This advancement sets the stage for more authentic space-based biological studies, vital for ensuring the safety of future space explorations.
Sonic play: on the B-side of literacy and songwriting
Authors: Petchauer Emery , Harvey Tia , Ybarra Rolando 
Published: November 2023

Purpose
This paper aims to explore sonic play in close proximity to a music, literacy and songwriting for social change community-based initiative. The authors leverage ideas about time, space and narrative under the concept of sonic flux to understand youth’s sonic and aural play on digital beatmaking technologies. In doing so, the authors break from a fixation on the written and spoken word and address sound, aurality and Blacktronika creative technologies that are often present but muted in literacies and songwriting scholarship.

Design/methodology/approach
The authors’ team consisted of three community-based teaching artists who situated this inquiry around their own practice with youth. The authors conducted this inquiry through a qualitative, participatory and community-engaged research approach. As such, the authors codeveloped and carried out research questions and sense-making protocols that balance the power of interpretation and epistemologies among us.

Findings
The findings address how the joy, laughter and play of one young musician, Malik, moved across different conceptions of time while learning to make beats in proximity to peers writing lyrics for songs. Specifically, the authors unpack how Malik’s play with mobile sound-making technologies moved across linear and nonlinear time that characterize sonic space and sound art, not music and lyric writing. In doing so, the loops and durations of his sonic play were sometimes unbound by narrative structures that often code literacy and songwriting initiatives.

Originality/value
The authors’ inquiry speaks into literacy and songwriting initiatives that privilege spoken, written and performed word over sound. The authors ask what kind of participating structures, collaborations, ontologies and youth epistemologies open up if we think of youth in these spaces not only as performers but as programmers tinkering with time in the machine. In addition, the authors ask what literacy and songwriting spaces might look like when the duration, loops and drones of sonic space and not music are the structuring codes over narratives and linearity.
Employee based brand equity: a systematic review of literature, framework development, and implications for future research
Authors: Sousa Bianca , Ferreira Pedro 
Published: November 2023

Purpose
Through a systematic literature review, this paper aims to endeavor to present a thorough historical perspective on the evolution of employee-based brand equity (EBBE), offering a comprehensive understanding of its development. The study explores the general model, causes and effects of EBBE, as well as the role of culture, leadership and brand management in building EBBE. The paper proposes an integrative framework to understand the interrelationships between the various dimensions of EBBE and offers practical guidelines for future research and the business world.

Design/methodology/approach
The paper uses a systematic literature review approach to analyze and synthesize 30 studies on EBBE retrieved from SCOPUS and Web of Science. The analysis involves a thematic and content-based examination of the literature, which is organized into three thematic groups.

Findings
The review highlights the importance of EBBE as a driver of organizational performance and success. The paper identifies the evolution of the major themes, trends and debates in the literature and suggests areas for future research. It underscores the need for more qualitative, multi-level and longitudinal research on EBBE, as well as the exploration of the links between EBBE and other forms of brand equity.

Originality/value
This paper is one of the first systematic literature reviews of EBBE, offering a comprehensive and integrated view of the existing literature since the beginning of this concept. The paper’s originality lies in its proposed integrative framework that captures the interrelationships between the various dimensions of EBBE and provides practical guidelines for future research and the business world.
Familiarity bias in direct stock investment by individual investors
Authors: Lei Shan , Mathers Ani Manakyan 
Published: November 2023

PurposeThis study examines the relationship between investors' familiarity bias, including the home bias and endowment bias, and their financial situations, expectations and personal characteristics.Design/methodology/approachUsing the 2019 Survey of Consumer Finances, the authors utilize an ordinary least squares regression to identify the presence of endowment bias and home bias in individual investors' direct stock holdings and use a Heckman selection model to examine determinants of the extent of endowment bias and home bias.FindingsThis study finds that investors with higher income and more education, men, non-white investors and people with greater risk tolerance are actually at a greater risk of endowment bias. This study also identifies a profile of investors that are more likely to have a home bias: with less financial sophistication, lower net worth, older, female, more risk-averse, with a positive expectation about the domestic economy and a relatively shorter investment horizon.Originality/valueThis paper is among the first to use US investors' directly reported stock holdings to examine the individual characteristics that are correlated with greater familiarity bias, providing financial professionals with information about how to allocate their limited time in providing education to a variety of clients.
Autonomy, Power and the Special Case of Scarcity: Consumer Adoption of Highly Autonomous Artificial Intelligence
Authors: Frank Darius‐Aurel , Otterbring Tobias 
Published: November 2023

AbstractUnlike previous generations of artificial intelligence (AI), AI assistants today can autonomously perform actions without human input or intervention. Several studies have proposed but not tested the notion that increased levels of AI autonomy may ultimately conflict with consumers’ fundamental need for autonomy themselves. Across five experiments (N = 1981), including representative samples and pre‐registered hypotheses, we investigate consumer responses to high (vs. low) AI autonomy in the context of online shopping. The results show a pronounced negative effect of high AI autonomy on consumers’ adoption intentions – an effect mediated by consumers’ relative state of powerlessness in the presence of high AI autonomy. However, when consumers face situations characterized by scarcity, such as when preferred options are being sold out rapidly (e.g. Black Friday), the aversive aspects of high (vs. low) AI autonomy are attenuated. Together, these findings offer novel insights regarding whether, when and why consumers are willing to adopt high (vs. low)‐autonomy AI assistants in online shopping settings.
Sharing suits and letters: redressing late‐capitalist precarity in South Korea
Authors: Fedorenko Olga 
Published: November 2023

AbstractThe contemporary sharing economy comprises a variety of technology‐mediated user‐to‐user transactions and reveals both the extremes of the late‐capitalist regime of accumulation and possible paths to supersede it. To critically explore the idea of the sharing economy, this article examines how it has been mobilized by a non‐profit startup in neoliberalized South Korea. Open Closet cheaply rents donated suits to precarious job‐seekers for interviews, while requesting that donors and renters write each other letters with their ‘suit stories’. The article tracks how sharing at Open Closet is realized via circulations of suits, letters, and ‘warm hearts’, and how its meanings and obligations are interpreted via the historical relations of mutual responsibility within local collectivities of belonging. The article thus illuminates new imaginaries for livelihoods, subjecthoods, and solidarities that emerge when the contemporary sharing economy ambiguates capitalist and non‐capitalist relations, becoming a site for experimentation with affectivity and mutuality among strangers.
The Origin of Differential Object Marking and Tripartite Alignment in Udi (East Caucasian)
Authors: Authier Gilles 
Published: November 2023

AbstractThanks to the discovery in Mount Sinai Monastery of the Albanian palimpsest, which contains fragments of the Bible in an ancient form of Udi, this language has become the earliest attested member of the East Caucasian family. However, due to its long evolution in contact with unrelated languages, both old and modern Udi show many characteristics unknown to their closest relatives, including Differential Object Marking. Combined with ergative case marking, this feature results in a rare ‘tripartite alignment’. After describing the case marking of arguments in Lezgian, modern dialects of Udi and the three non‐East Caucasian languages of the area (Tat, Azeri and Armenian) showing Differential Object Marking, we examine the available Old Udi / Caucasian Albanian data, compare them with data from Old Armenian, Old Turkic and Middle Iranian, and try to assess the best candidate for the source of the Udi phenomenon in the light of what is known about its history in terms of contact and sociolinguistic dominance.
Acetaldehyde‐mediated increase in glutamatergic and N‐acetylaspartate neurometabolite levels in the midcingulate cortex of ALDH2*1/*2 heterozygous young adults
Authors: Ueno Fumihiko , Sakuma Mutsuki , Nakajima Shinichiro , Tsugawa Sakiko , Ochi Ryo , Tani Hideaki , Noda Yoshihiro , Graff‐Guerrero Ariel , Uchida Hiroyuki , Mimura Masaru , Oshima Shunji , Matsushita Sachio 
Published: November 2023

AbstractBackgroundTo elucidate the neurobiology underlying alcohol's effect on the human brain, we examined the acute effects of moderate alcohol administration on levels of glutamatergic neurometabolites and N‐acetylaspartate, an amino acid found in neurons, may reflect disordered neuronal integrity.MethodsEighteen healthy Japanese participants (7 males/11 females) aged 20–30 years who were heterozygous for an inactive allele of acetaldehyde dehydrogenase‐2 (ALDH/*1/*2) were included. Participants underwent an intravenous alcohol infusion using the clamp method at a target blood alcohol concentration (BAC) of 0.50 mg/mL for 90 min within a range of ±0.05 mg/mL. We examined glutamate + glutamine (Glx) and N‐acetylaspartate N‐acetylaspartylglutamate (NAA) levels in the midcingulate cortex (MCC) using 3 T 1H‐MRS PRESS at baseline, 90 min, and 180 min (i.e., 90 min after alcohol infusion was finished). A two‐way repeated‐measures analysis of variance was used to assess longitudinal changes in Glx and NAA levels, with time and sex as within‐ and between‐subject factors, respectively. Pearson's correlation coefficients were calculated among neurometabolite levels and BAC or blood acetaldehyde concentration (BAAC).ResultsBoth Glx (F(2,32) = 8.15, p = 0.004, η2 = 0.15) and NAA (F(2,32) = 5.01, p = 0.04, η2 = 0.07) levels were increased after alcohol injection. There were no sex or time × sex interaction effects observed. NAA levels were positively correlated with BAAC at 90 min (r(13) = 0.77, p = 0.01). There were no associations between neurometabolite levels and BAC.ConclusionsBoth Glx and NAA levels in the MCC increased in response to the administration of moderate concentrations of alcohol. Given positive associations between NAA levels and BAAC and the hypothetical glutamate release via dopamine pathways, the effects of drinking on the MCC in the acute phase may be ascribed to acetaldehyde metabolized from alcohol.
Identification of genomic regions associated with differences in fleece type in Huacaya and Suri alpacas (Vicugna pacos)
Authors: Tan K. , Adeniyi O. O. , Letko A. , RuddGarces G. , Manz E. , Wagner H. , Zanolari P. , Drögemüller C. , Lühken G. 
Published: November 2023

AbstractThe difference in fleece type is the distinguishing trait between the two types of alpacas (Vicugna pacos), Huacaya and Suri. The Suri fleece type has been found to be inherited dominantly over the Huacaya type, resulting in offspring with the Suri phenotype. The aim of our study was to map genomic regions associated with the two different fleece types. In this study, 91 alpacas (54 Huacayas and 37 Suris) from Germany and Switzerland were genotyped using the 76k alpaca SNP array. Only 59k chromosome‐localised markers map to the alpaca reference assembly VicPac3.1, and after quality control 49 866 SNPs, were retained for population structure assessment and to conduct a genome‐wide association study. Both principal component and neighbour‐joining tree analysis showed that the two fleece‐type cohorts overlapped rather than forming two distinct clusters. Genome‐wide significantly associated markers were observed in the scaffold region of chromosome 16 (NW_021964192.1), which contains a cluster of keratin genes. A haplotype predominantly found in Suri alpacas has been identified which supports dominant inheritance. Variant filtering of nine whole‐genome sequenced alpacas from both fleece types in the critical interval of 0.4 Mb did not reveal perfect segregation of either fleece type for specific variants. To our knowledge, this is the first study to use the recently developed species‐specific SNP array to identify genomic regions associated with differences in fleece type in alpacas. There are still some limitations, such as the preliminary status of the reference assembly and the incomplete annotation of the alpaca genome.
Lay beliefs about the perceived harmfulness of excess weight: Influence of weight status and the cause of weight
Authors: Black Clancy K. , Vartanian Lenny R. , Faasse Kate 
Published: November 2023

AbstractHealth campaigns often emphasise the association between excess weight and poor health. Past research suggests that whether an individual's excess weight is viewed as harmful is partially explained by the quantity of excess weight. The present research explored whether the purported cause of excess weight also influences its perceived harmfulness. Across two studies (total N = 577), participants read information about target individuals whose excess weight was caused by different factors (unhealthy lifestyle vs. medical condition). Participants rated the extent to which the target's weight was harmful and also recommended health‐related behaviours to the target. For the target with overweight, when her weight was described as being caused by unhealthy behaviours as opposed to a medical condition, her weight was rated as more harmful, and she was recommended to engage in more healthy behaviours. For the target with obesity, her weight was viewed as harmful irrespective of its described cause. Compared with the target with overweight, the weight of the target with obesity was rated as more harmful and she was recommended to diet more. Perceptions of the harmfulness of ‘overweight’ are influenced by the purported cause of that overweight, whereas obesity itself is viewed as harmful, regardless of the cause.
Intravenously engrafted human multilineage‐differentiating stress‐enduring (Muse) cells rescue erectile function after rat cavernous nerve injury
Authors: Koyama Juntaro , Yamashita Shinichi , Kato Yuya , Nezu Kunihisa , Goto Takuro , Fujii Shinji , Suzuki Yu , Nakayashiki Atsushi , Kawasaki Yoshihide , Kawamorita Naoki , Okita Hitomi , Ito Takako , Kushida Yoshihiro , Goto Masafumi , Dezawa Mari , Tominaga Teiji , Niizuma Kuniyasu , Ito Akihiro 
Published: November 2023

ObjectiveTo evaluate the effect of intravenous administration of human multilineage‐differentiating stress‐enduring (Muse) cells on rat postoperative erectile dysfunction (ED) with cavernous nerve (CN) injury without an immunosuppressant.Materials and MethodsMale Sprague–Dawley rats were randomised into three groups after CN crush injury. Either human‐Muse cells, non‐Muse mesenchymal stem cells (MSCs) (both 1.0 × 105 cells), or vehicle was infused intravenously at 3 h after CN injury without immunosuppressant. Erectile function was assessed by measuring intracavernous pressure (ICP) and arterial pressure (AP) during pelvic nerve electrostimulation 28 days after surgery. At 48 h and 28 days after intravenous infusion of Muse cells, the homing of Muse cells and non‐Muse MSCs was evaluated in the major pelvic ganglion (MPG) after CN injury. In addition, expressions of C‐X‐C motif chemokine ligand (Cxcl12) and glial cell line‐derived neurotrophic factor (Gdnf) in the MPG were examined by real‐time polymerase chain reaction. Statistical analyses and comparisons among groups were performed using one‐way analysis of variance followed by the Tukey test for parametric data and Kruskal–Wallis test followed by the Dunn–Bonferroni test for non‐parametric data.ResultsThe mean (SEM) ICP/AP values at 28 days were 0.51 (0.02) in the Muse cell group, 0.37 (0.03) in the non‐Muse MSC group, and 0.36 (0.04) in the vehicle group, showing a significant positive response in the Muse cell group compared with the non‐Muse and vehicle groups (P = 0.013 and P = 0.010, respectively). In the MPG, Muse cells were observed to be engrafted at 48 h and expressed Schwann cell markers S100 (~46%) and glial fibrillary acidic protein (~24%) at 28 days, while non‐Muse MSCs were basically not engrafted at 48 h. Higher gene expression of Cxcl12 (P = 0.048) and Gdnf (P = 0.040) was found in the MPG of the Muse group than in the vehicle group 48 h after infusion.ConclusionIntravenously engrafted human Muse cells recovered rat erectile function after CN injury in a rat model possibly by upregulating Cxcl12 and Gdnf.