bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of lactylation in tumor growth and cancer progression
Authors: Al-Malsi Khulood , Xie Sinan , Cai Yunshi , Mohammed Nader , Xie Kunlin , Lan Tian , Wu Hong 
Published: February 2025

BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. In addition to its metabolic contributions, lactate has far-reaching repercussions. This review highlights the role of lactate in the course of cancer by highlighting lactylation as a unique epigenetic alteration. The purpose of this review is to clarify the functions of lactate in the biology of tumors, with a particular focus on the translational potential of lactylation pathways in cancer diagnosis and treatment approaches.MethodsThis review summarizes research on the relationship between lactate and cancer, with an emphasis on histone lactylation, its effect on gene expression, and its influence on the tumor microenvironment. By establishing a connection between metabolic byproducts and epigenetic gene regulation, we investigated how lactylation affects immune regulation, inflammation, and cellular repair.FindingsHistone lactylation, or the addition of lactate to lysine residues on histone proteins, increases transcriptional activity and facilitates the expression of genes involved in homeostasis and repair. These findings have important implications for cancer treatment. Lactylation, for example, activates genes such as Arg1, which is a hallmark of the M2 macrophage phenotype implicated in immunosuppression and tumor growth. The ability of lactate to dynamically alter gene expression is further supported by its function as a histone deacetylase(HDAC)inhibitor and its impact on histone acetylation. Its wide-ranging involvement in cellular metabolism and epigenetic control has been demonstrated by the discovery of particular lactylation sites on histones in various cell types, including cancer cells.
Adaptive Judo and neuropathy: a mini review on motor skills, balance, and quality of life improvement
Authors: Nerozzi Erika , Prada Valeria , Pegreffi Francesco , Grandis Marina , Schenone Angelo , Pierantozzi Emanuela 
Published: February 2025

IntroductionPeripheral neuropathies are progressive conditions characterized by muscle weakness, impaired balance, and reduced quality of life. Rehabilitation programs and adaptive sports have shown promise in mitigating these effects. This paper explores the potential of adaptive Judo to improve motor skills, balance, and overall quality of life in patients with neuropathy.MethodsWe review existing literature, analyze the benefits of Judo’s physical and cognitive demands, and propose adaptive guidelines for its implementation.ResultsThis study highlights Judo’s potential as a cost-effective and scalable intervention to support neuropathic patients.ConclusionThis review emphasizes the evidence-based benefits of adapted Judo training has the potential to transform both the physical and emotional health of neuropathic individuals.
Relationship between physical literacy and mental health in adolescents: a moderated mediation model with resilience and physical activity as variables
Authors: Shanshan Zhu , Ping Tao , Jiabin Lin , Tianzhuo Liu , Xiaomei Lai , Bolei Wang , Leifu Dai , Jianfeng Tang 
Published: February 2025

IntroductionPhysical literacy is defined as the motivation, confidence, physical competence, knowledge, and understanding to value and take responsibility for engaging in physical activities for life, and may be associated with higher mental health; however, few studies have explored the processes underlying these positive associations.ObjectivesThe present study aimed to explore the role of resilience in the relationship between physical literacy and mental health, and further examines the mediating role of physical activity.MethodsThis cross-sectional study recruited a sample of 1,022 (aged 10–18 years, Mage = 14.84, SD = 1.79, 44.9% male) Chinese students, grades five to twelve, via physical education courses. The hypothesized moderated mediation model was employed using Model 4 and Model 8 of the PROCESS macro for SPSS to examine the relationships between physical literacy, mental health, resilience, and physical activity.ResultsPhysical literacy was positively and significantly correlated with mental health (r = 0.364, p &lt; 0.001), and resilience (r = 0.486, p &lt; 0.001). After controlling for sex and grade variables, resilience mediated the relationship between adolescent physical literacy and mental health, physical activity moderated the relationship between physical literacy and resilience in the mediator model but not between physical literacy and mental health.DiscussionThe present study suggests that could physical literacy predict increased levels of resilience, which could then lead to higher mental health. However, this mediation effect may fluctuate across individuals with different levels of physical activity. Overall, this study may reveal that physical literacy promotes resilience and mental health processes in individuals with different levels of physical activity.
Exploring the relationship between mental health status and life events in children and adolescents: the role of mediating factors
Authors: Xie Jiemei , Cheng Guoqiang , Zhou Mingliang , Liang Qisheng , Wang Qianjin 
Published: February 2025

BackgroundThe mental health status of children and adolescents is significantly influenced by negative life events, yet there is a lack of comprehensive analysis on mediating factors. This study aims to examine the relationship between negative life events and symptoms of anxiety and depression in children and adolescents, as well as to identify potential mediating factors.MethodsIn May 2022, cluster-randomized sampling was used to select 8041 primary, middle, and high school students in Zhaoqing City, Guangdong Province, for the final analysis. The Adolescent Life Events Scale, Self-Rating Anxiety Scale, and Self-Rating Depression Scale were employed to assess negative life events, anxiety symptoms, and depressive symptoms, respectively. Pearson correlation analysis and linear regression analysis were utilized to identify risk factors, and the Bootstrap method was applied for mediation analysis.ResultsThe study revealed that 80.52% of children and adolescents experienced negative life events, with 23.38% reporting anxiety symptoms and 42.57% reporting depressive symptoms. Significant positive correlations were observed between negative life events and anxiety symptoms (r = 0.32, p &lt; 0.001), as well as depressive symptoms (r = 0.44, p &lt; 0.001). Mediation analysis further demonstrated that anxiety and depressive symptoms acted as mutual mediators in the relationship between negative life events and each other.ConclusionsThis study underscores the complex interplay between anxiety, depression, and negative life events in children and adolescents. These findings can inform strategies to help mitigate the emotional impact of negative life events, enhance mental health, and provide a scientific basis for developing effective interventions.
Research on the relationship between social support and academic self-efficacy among college students: a multivariate empirical analysis
Authors: Chen Chunmei , Zhu Yujie , Xiao Fanghao 
Published: February 2025

BackgroundThe critical role of social support in college students’ academic development cannot be ignored. This study aims to analyze the interrelationships and potential mechanisms between social support, sense of security, family cultural capital and academic self-efficacy.MethodsA multivariate moderated mediation model was constructed by surveying 1,119 college students using the Social Support Scale, the Sense of Security Scale, the Academic Self-efficacy Scale, and the Family Cultural Capital Scale.Results(1) social support significantly increases sense of security; (2) sense of security significantly enhances academic self-efficacy; (3) social support directly contributes to academic self-efficacy; and (4) sense of security partially mediates the relationship between social support and academic self-efficacy; (5) family cultural capital plays a moderating role in the effects of social support on academic self-efficacy, especially in the first half of the direct and indirect effects.ConclusionThese findings could provide an important theoretical basis and practical guidance for further understanding and enhancing academic self-efficacy among college students.
Deep learning technology: enabling safe communication via the internet of things
Authors: Salama Ramiz , Mohapatra Hitesh , Tülbentçi Tuğşad , Al-Turjman Fadi 
Published: February 2025

IntroductionThe Internet of Things (IoT) is a new technology that connects billions of devices. Despite offering many advantages, the diversified architecture and wide connectivity of IoT make it vulnerable to various cyberattacks, potentially leading to data breaches and financial loss. Preventing such attacks on the IoT ecosystem is essential to ensuring its security.MethodsThis paper introduces a software-defined network (SDN)-enabled solution for vulnerability discovery in IoT systems, leveraging deep learning. Specifically, the Cuda-deep neural network (Cu-DNN), Cuda-bidirectional long short-term memory (Cu-BLSTM), and Cuda-gated recurrent unit (Cu-DNNGRU) classifiers are utilized for effective threat detection. The approach includes a 10-fold cross-validation process to ensure the impartiality of the findings. The most recent publicly available CICIDS2021 dataset was used to train the hybrid model.ResultsThe proposed method achieves an impressive recall rate of 99.96% and an accuracy of 99.87%, demonstrating its effectiveness. The hybrid model was also compared to benchmark classifiers, including Cuda-Deep Neural Network, Cuda-Gated Recurrent Unit, and long short-term memory (Cu-DNNLSTM and Cu-GRULSTM).DiscussionOur proposed technique outperforms existing classifiers based on various evaluation criteria such as F1-score, speed efficiency, accuracy, and precision. This shows the strength of the approach in threat detection and highlights the potential of combining SDN with deep learning for IoT vulnerability assessment.
Intralobar pulmonary sequestration complicated by a giant supplying artery aneurysm presenting for 9 years: a case report
Authors: Weng Wei , Chi Xinle , Liu Ze , Chen Weiqian , Wang Shengze , Cai Wenjie , Wu Hai , Chen Yaomeng 
Published: February 2025

BackgroundThis article reports a case of a intralobar pulmonary sequestration (IPS) with a significantly large feeding artery aneurysm and shares the successful treatment experience.Case presentationA male was diagnosed with IPS combined with a feeding artery aneurysm approximately 74 mm × 61 mm in nine years ago but refused thoracotomy at that time. The patient presented this time due to an infection, and a CT scan revealed a significant increase in the lesion size to approximately 123 mm × 100 mm. After controlling the pulmonary inflammation, the patient underwent thoracoscopic ligation of the supplying artery, followed by an open chest excision of the sequestrated pulmonary aneurysm and left lower lobectomy, and the recovery post-surgery was very good.ConclusionWhen a sequestrated lung enlarges significantly, it is crucial to consider not only the conventional possibility of malignancy but also the rare coexistence of aneurysms. Thoracoscopic ligation of the supplying artery followed by open chest surgery is an effective treatment approach for IPS combined with a large feeding artery aneurysm.
Impact of Minimal Incision Repair of Rectus Abdominis Diastasis on Quality of Life and Stress Incontinence: A Prospective Study
Authors: Katawazai Asmatullah , Wallin Göran , Ärlebäck Anna , Sandblom Gabriel 
Published: February 2025

AimThis study evaluates the impact of the minimal incision repair of rectus abdominis diastasis (MIRRAD) procedure on physical activity, muscle strength, quality of life, and overall satisfaction in women with postpartum rectus abdominis diastasis (PP-RAD).MethodsA cohort of 31 female patients, aged 20–50 years, diagnosed with PP-RAD unresponsive to conservative treatment, underwent the MIRRAD procedure. Assessments were conducted preoperatively and 1 year postoperatively, these included the Modified Abdominal Trunk Function Protocol (MATFP), Disability Rating Index (DRI), and Urinary Disability Index (UDI) questionnaires. Physical activity intensity was monitored using accelerometers.ResultsSignificant improvements were observed in vigorous physical activities (Z = −2.352, p = 0.019), vector magnitude counts per minute (Z = −2.163, p = 0.031), and steps per minute (Z = −3.131, p = 0.002). DRI showed significant improvements in physical tasks like dressing, walking, and strenuous work (Z ranging from −2.705 to −4.603, p &lt; 0.001). UDI indicated significant improvements in urinary symptoms, including reduced frequency (Z = −2.984, p = 0.003) and less urinary leakage (Z = −2.357, p = 0.018). MATFP demonstrated gains in back and abdominal muscle strength (Z = −4.321, p &lt; 0.001) and trunk stability (Z = −3.991, p &lt; 0.001).ConclusionThe MIRRAD procedure significantly improves physical strength, trunk stability, and urinary function, enhancing daily activities and overall physical health in women with PP-RAD. Further research is recommended to evaluate long-term outcomes.
Stock Structure of the Gulf Hake Urophycis cirrata (Teleostei: Phycidae) in South-Western Atlantic Using Otolith Shape and Elemental Analyses
Authors: Santificetur César , Rossi-Wongtschowski Carmen Lúcia Del Bianco , Ruperti André , Almeida Agostinho , Pinto Edgar , Correia Alberto Teodorico 
Published: February 2025

Urophycis cirrata is an important demersal fish species targeted by Brazilian industrial fisheries. With high exploitation rates, its stock(s) is(are) currently deemed fully exploited or overexploited. While basic ecological information, such as length at first maturity, exists, knowledge of its population structure is limited. A sub-sample of 90 sagittal otoliths of U. cirrata juveniles (300–411 mm total length) collected during the Program for Assessment of the Sustainable Potential of Living Resources in the Exclusive Economic Zone (REVIZEE) in 2001/2002 was analyzed. Samples came from the outer continental shelf and upper slope of the southeast-south Brazilian coast, divided into three regions: northern (Cabo São Tomé to São Sebastião), central (São Sebastião to Cabo Santa Marta Grande), and southern (Cabo Santa Marta Grande to Chuí). Otolith shape (elliptic Fourier descriptors) and elemental (element:Ca) signatures were examined using univariate (ANOVA, Tukey) and multivariate (MANOVA, LDFA) statistical methods. An overall reclassification success rate of 86% was achieved using both signatures. However, individuals from the three regions were not fully separable, indicating a single, albeit not homogeneous, population unit for fisheries management. As fish stocks are dynamic, contemporary studies should be conducted to verify whether this population structure persists.
Classical Layer-Resolving Scheme for a System of Two Singularly Perturbed Time-Dependent Problems with Discontinuous Source Terms and Spatial Delay
Authors: Mathiyazhagan Joseph Paramasivam , Karuppusamy Ramiya Bharathi , Chatzarakis George E. , Panetsos S. L. 
Published: February 2025

In this paper, a classical layer-resolving finite difference scheme is formulated to solve a system of two singularly perturbed time-dependent initial value problems with discontinuity occurring at (y,t) in the source terms and Robin initial conditions. The delay term occurs in the spatial variable, and the leading term of the spatial derivative of each equation is multiplied by a distinct small positive perturbation parameter, inducing layer behaviors in the solution domain. Due to the presence of perturbation parameters, discontinuous source terms, and delay terms, initial and interior layers occur in the solution domain. In order to capture the abrupt change that occurs due to the behavior of these layers, the solution is further decomposed into smooth and singular components. Layer functions are also formulated in accordance with layer behavior. Analytical results and bounds of the solution and its components are derived. The formulation of a finite difference scheme involves discretization of temporal and spatial axes by uniform and piecewise uniform meshes, respectively. The formulated scheme achieves first-order convergence in both time and space. At last, to bolster the numerical scheme, example problems are computed to prove the efficacy and accuracy of our scheme.
Normally-off AlGaN/GaN MIS-HEMTs with high 2DEG mobility enabled by shallow recess and oxygen plasma treatment
Authors: Ishiguro Masaki , Sekiyama Kishi , Baratov Ali , Maeda Shogo , Igarashi Takahiro , Tajuddin Nur Syazwani Binti Ahmad , Islam Naeemul , Terai Suguru , Yamamoto Akio , Kuzuhara Masaaki , Sarkar Biplab , Amano Hiroshi , Asubar Joel T. 
Published: February 2025

Abstract
We demonstrate a normally-off operation in Al2O3/AlGaN/GaN MIS-HEMTs with a high two-dimensional electron gas (2DEG) mobility enabled by a shallow recess channel structure and oxygen plasma treatment. In the channel region, the original 25-nm-thick AlGaN barrier layer was thinned down to 9 nm, which in principle, should yield a normally-on operation. However, we show that a pre-insulator deposition oxygen plasma treatment shifts the threshold voltage to +1.4 V. The relatively thick AlGaN barrier facilitated a minimal sacrifice of channel 2DEG mobility retaining a value as high as 1800 cm2V−1s−1, resulting in a high drain current of 600 mA mm−1.
Schizofreniczny surrealizm ekranu
Authors: Giżycki Marcin 
Published: February 2025

Autor przedstawia swoje refleksje dotyczące wyszperanej w antykwariacie książki Williama Earle’a Surrealizm of the Movies (1987). William Earle (1919-1988), wykładowca filozofii na Northwestern University w Chicago, był autorytetem od egzystencjalizmu i fenomenologii. Pozostawił po sobie kilka książek o tematyce filozoficznej i jedną poświęconą kinu, która – wbrew tytułowi – nie jest wcale historią filmu surrealistycznego, ale zbiorem erudycyjnych i wyjątkowo zjadliwych esejów o tradycyjnym kinie. Rozważania filozofa dotyczące ontologii kina prowadzą go do konkluzji, że surrealizm jest wpisany w istotę kina. Giżycki zauważa, że pasjonujące eseje Earle’a czyta się w dużej mierze jak manifest kina antyrealistycznego. Chciałoby się więc tezy filozofa skonfrontować z praktykę – wiadomo bowiem (z okładki książki odkrytej w antykwariacie), że Earl zrealizował ponad 20 „surrealistyczno-dadaistycznych” filmów. Niestety, próżno ich szukać w filmotekach, sklepach czy Internecie. Giżycki pyta: A może po prostu nigdy nie powstały, są tylko dadaistyczno-surrealistycznym żartem?
Analisa dan Pengujian Kenaikan Suhu pada Minyak Ester Sintetis pada Transformator Distribusi 20/0,4 kV Kapasitas Daya 2500 kVA
Authors: Sutowo Achmad , Sofwan Agus , Pandowo Baskoro Abie 
Published: February 2025

Transformator merupakan peralatan Listrik yang digunakan sebagai penaik dan penurun tegangan pada system arus bolak balik (AC) baik satu fasa maupun tiga fasa. Peralatan tersebut terbangun oleh beberapa komponen utama seperti inti besi, belitan dan cairan pendingin atau yang sering disebut dengan minyak trafo. Minyak trafo sendiri berfungsi sebagai pendingin belitan primer sekunder dan sebagai isolasi antar belitan. Namun seiring dengan pembebanan yang tinggi, umur trafo maka suhu dan peforma minyak trafo cenderung turun. Penelitian ini dilakukan dengan metode adalah menguji besar kenaikan suhu minyak tertinggi atau dengan istilah top-liquid temperature dan top-liquid temperature rise pada trafo distribusi dengan skema berdasarkan standar IEC 60076-2-2011 yang dilakukan pengujian dengan cara injeksi arus pada sisi primer sedangkan sisi sekunder dihubung singkat. Kenaikan suhu rata-rata dari minyak isolasi, khususnya di bagian atas transformator (top liquid temperature rise), saat beroperasi di atas suhu ambien. Metrik ini lebih fokus pada kenaikan suhu yang terjadi di bagian atas transformator, yang seringkali merupakan area di mana suhu cenderung lebih tinggi karena efek termal dari proses operasi transformator. Hasil yang diperoleh menyatakan bahwa besarnya pada uji suhu tertinggi minyak terhadap waktu dengan kondisi tunak suhu tertinggi top-liquid temperature k sebesar 83,2°C dan , dan hasil pengujian suhu kenaikan ( minyak terhadap waktu ketika kondisi keadaan tunak top-liquid temperature rise pada suhu sebesar 54,47 °C. Hasil ini menunjukan terjadi perubahan yang cukup signifikan.
Kata kunci: top-liquid temperature, top-liquid temperature rise, keadaan tunak
The Effect Of Perceived Value And Customer Satisfaction On Customer Loyalty (Case Study On Solaria Bencoolen Mall Customers)
Authors: Wahyuni Intan Tri , Subandrio Subandrio 
Published: February 2025

The title of this research is the effect of perceived value and customer satisfaction on customer loyalty (case study on Solaria Bencoolen Mall customers). This research is based on the importance of customer loyalty for business companies. Some of the factors that influence customer loyalty are perceived value and customer satisfaction. This study aims to determine the effect of perceived value and customer satisfaction on customer loyalty of customers Solaria Bencoolen Mall restaurant.This type of research is quantitative research with a descriptive approach. The research population is all Solaria Bencoolen Mall restaurant customers. The sample size was 88 people, taken using accidental sampling technique. Data collection using a questionnaire. Data analysis techniques using Multiple Linear Regression analysis. Partial test results show that perceived value has a positive and significant effect on customer loyalty variables (tcount = 3.516 and Sig = 0.001) and customer satisfaction variables have a positive and significant effect on customer loyalty variables (tcount = 5.328 and Sig = 0.000). The simultaneous test results show that the perceived value variable and the customer satisfaction variable together have a significant effect on customer loyalty (Fhitung = 72,988 and Sig = 0.000). The regression equation of the test results is: Y = 4.664 + 0.298 X1 + 0.510 X2, with a Coefficient of Determination value of 63.2% (R Square = 0.632). Where the Coefficient of Determination means that together perceived value and customer satisfaction contribute 63.2% in influencing customer loyalty of Solaria Bencoolen Mall restaurant customers.