bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous percolation in a Hilbert space for a large system of qubits
Authors: Watabe Shohei , Serikow Michael Zach , Kawabata Shiro , Zagoskin Alexandre 
Published: November 2023

AbstractThe development of percolation theory was historically shaped by its numerous applications in various branches of science, in particular in statistical physics, and was mainly constrained to the case of Euclidean spaces. One of its central concepts, the percolation transition, is defined through the appearance of the infinite cluster, and therefore cannot be used in compact spaces, such as the Hilbert space of an N-qubit system. Here, we propose its generalization for the case of a random space covering by hyperspheres, introducing the concept of a “maximal cluster”. Our numerical calculations reproduce the standard power-law relation between the hypersphere radius and the cover density, but show that as the number of qubits increases, the exponent quickly vanishes (i.e., the exponentially increasing dimensionality of the Hilbert space makes its covering by finite-size hyperspheres inefficient). Therefore the percolation transition is not an efficient model for the behavior of multiqubit systems, compared to the random walk model in the Hilbert space. However, our approach to the percolation transition in compact metric spaces may prove useful for its rigorous treatment in other contexts.
Triterpenoid Compounds from Cyclocarya paliurus: A Review of Their Phytochemistry, Quality Control, Pharmacology, and Structure–Activity Relationship
Authors: Zhang Shuran , He Junyu , Li Jie , He Haibo , He Yumin , Wang Xiao , Shu Heng , Zhang Jihong , Xu Daoxiang , Zou Kun 
Published: November 2023

Cyclocarya paliurus (Batalin) Iljinskaja (C. paliurus) is a single species of Cyclocarya paliurus in Juglandaceae. It is a unique rare medicinal plant resource in China that is mainly distributed in the south of China. The leaves of C. paliurus, as a new food ingredient, are processed into tea products in daily life. Triterpenoids are the main active ingredient in C. paliurus. So far, 164 triterpenoid compounds have been isolated and identified from C. paliurus, which are included 3,4-seco-dammaranes, dammaranes, oleanane, ursane, lupinanes, taraxeranes, and norceanothanes. Modern pharmacological studies manifested that these ingredients have a wide range of pharmacological activities both in vitro and in vivo, such as reducing blood sugar, lowering blood lipids, and anti-tumor, anti-inflammatory, anti-oxidant, and other activities. In addition, current results indicate that the pharmacological mechanisms of triterpenoids were closely related to their chemical structure, molecular signaling pathways, and the expression of related proteins. In order to further study C. paliurus based on the current research situation, this review summarizes the prospect and systematic summary of the triterpenes of C. paliurus from the aspects of structural characteristics, quality control, biological activity, and the structure–activity relationship, which provide a reference for further research and application of the triterpenoids from C. paliurus in the field of functional food and medicine.
ISP Agent: A Generalized In-storage-processing Workload Offloading Framework by Providing Multiple Optimization Opportunities
Authors: Kang Seokwon , Kim Jongbin , Lee Gyeongyong , Lee Jeongmyung , Seo Jiwon , Jung Hyungsoo , Song Yong Ho , Park Yongjun 
Published: November 2023

As solid-state drives (SSDs) with sufficient computing power have recently become the dominant devices in modern computer systems, in-storage processing (ISP), which processes data within the storage without transferring it to the host memory, is being utilized in various emerging applications. The main challenge of ISP is to deliver storage data to the offloaded workload. This is difficult because of the information gap between the host and storage, the data consistency problem between the host and offloaded workloads, and SSD-specific hardware limitations. Moreover, because the offloaded workloads use internal SSD resources, host I/O performance might be degraded due to resource conflicts. Although several ISP frameworks have been proposed, existing ISP approaches that do not deeply consider the internal SSD behavior are often insufficient to support efficient ISP workload offloading with high programmability.
In this article, we propose an ISP agent, a lightweight ISP workload offloading framework for SSD devices. The ISP agent provides I/O and memory interfaces that allow users to run existing function codes on SSDs without major code modifications, and separates the resources for the offloaded workloads from the existing SSD firmware to minimize interference with host I/O processing. The ISP agent also provides further optimization opportunities for the offloaded workload by considering SSD architectures. We have implemented the ISP agent on the OpenSSD Cosmos+ board and evaluated its performance using synthetic benchmarks and a real-world ISP-assisted database checkpointing application. The experimental results demonstrate that the ISP agent enhances host application performance while increasing ISP programmability, and that the optimization opportunities provided by the ISP agent can significantly improve ISP-side performance without compromising host I/O processing.
The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture
Authors: Graca Marques Joana , Pavlovic Blaz , Ngo Quy A. , Pedot Gloria , Roemmele Michaela , Volken Larissa , Kisele Samanta , Perbet Romain , Wachtel Marco , Schäfer Beat W. 
Published: November 2023

Abstract

Ewing sarcoma is an aggressive cancer with a defective response to DNA damage leading to an enhanced sensitivity to genotoxic agents. Mechanistically, Ewing sarcoma is driven by the fusion transcription factor EWS-FLI1, which reprograms the tumor cell epigenome. The nucleosome remodeling and deacetylase (NuRD) complex is an important regulator of chromatin function, controlling both gene expression and DNA damage repair, and has been associated with EWS-FLI1 activity. Here, a NuRD-focused CRISPR/Cas9 inactivation screen identified the helicase CHD4 as essential for Ewing sarcoma cell proliferation. CHD4 silencing induced tumor cell death by apoptosis and abolished colony formation. Although CHD4 and NuRD colocalized with EWS-FLI1 at enhancers and super-enhancers, CHD4 promoted Ewing sarcoma cell survival not by modulating EWS-FLI1 activity and its oncogenic gene expression program but by regulating chromatin structure. CHD4 depletion led to a global increase in DNA accessibility and induction of spontaneous DNA damage, resulting in an increased susceptibility to DNA-damaging agents. CHD4 loss delayed tumor growth in vivo, increased overall survival, and combination with PARP inhibition by olaparib treatment further suppressed tumor growth. Collectively, these findings highlight the NuRD subunit CHD4 as a therapeutic target in Ewing sarcoma that can potentiate the antitumor activity of genotoxic agents.

Significance:
CRISPR/Cas9 screening in Ewing sarcoma identifies a dependency on CHD4, which is crucial for the maintenance of chromatin architecture to suppress DNA damage and a promising therapeutic target for DNA damage repair-deficient malignancies.
Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao 
Published: November 2023

Abstract

Neuronal activity can drive progression of high-grade glioma by mediating mitogen production and neuron-glioma synaptic communications. Glioma stem cells (GSC) also play a significant role in progression, therapy resistance, and recurrence in glioma, which implicates potential cross-talk between neuronal activity and GSC biology. Here, we manipulated neuronal activity using chemogenetics in vitro and in vivo to study how it influences GSCs. Neuronal activity supported glioblastoma (GBM) progression and radioresistance through exosome-induced proneural-to-mesenchymal transition (PMT) of GSCs. Molecularly, neuronal activation led to elevated miR-184–3p in neuron-derived exosomes that were taken up by GSCs and reduced the mRNA N6-methyladenosine (m6A) levels by inhibiting RBM15 expression. RBM15 deficiency decreased m6A modification of DLG3 mRNA and subsequently induced GSC PMT by activating the STAT3 pathway. Loss of miR-184–3p in cortical neurons reduced GSC xenograft growth, even when neurons were activated. Levetiracetam, an antiepileptic drug, reduced the neuronal production of miR-184–3p-enriched exosomes, inhibited GSC PMT, and increased radiosensitivity of tumors to prolong survival in xenograft mouse models. Together, these findings indicate that exosomes derived from active neurons promote GBM progression and radioresistance by inducing PMT of GSCs.

Significance:
Active neurons secrete exosomes enriched with miR-184–3p that promote glioblastoma progression and radioresistance by driving the proneural-to-mesenchymal transition in glioma stem cells, which can be reversed by antiseizure medication levetiracetam.
Lineage Plasticity: The New Cancer Hallmark on the Block
Authors: Mehta Arnav , Stanger Ben Z. 
Published: November 2023

Abstract
Plasticity refers to the ability of cells to adopt a spectrum of states or phenotypes. In cancer, it is a critical contributor to tumor initiation, progression, invasiveness, and therapy resistance, and it has recently been recognized as an emerging cancer hallmark. Plasticity can occur as a result of cell-intrinsic factors (e.g., genetic, transcriptional, or epigenetic fluctuations), or through cell-extrinsic cues (e.g., signaling from components of the tumor microenvironment or selective pressure from therapy). Over the past decade, technological advances, analysis of patient samples, and studies in mouse model systems have led to a deeper understanding of how such plastic states come about. In this review, we discuss: (i) the definition of plasticity; (ii) methods to measure and quantify plasticity; (iii) the clinical relevance of plasticity; and (iv) therapeutic hypotheses to modulate plasticity in the clinic.
Financial revolution: a systemic analysis of artificial intelligence and machine learning in the banking sector
Authors: Jáuregui-Velarde Raúl , Andrade-Arenas Laberiano , Molina-Velarde Pedro , Yactayo-Arias Cesar 
Published: November 2023

This paper reviews the advances, challenges, and approaches of artificial intelligence (AI) and machine learning (ML) in the banking sector. The use of these technologies is accelerating in various industries, including banking. However, the literature on banking is scattered, making a global understanding difficult. This study reviewed the main approaches in terms of applications and algorithmic models, as well as the benefits and challenges associated with their implementation in banking, in addition to a bibliometric analysis of variables related to the distribution of publications and the most productive countries, as well as an analysis of the co-occurrence and dynamics of keywords. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework, forty articles were selected for review. The results indicate that these technologies are used in the banking sector for customer segmentation, credit risk analysis, recommendation, and fraud detection. It should be noted that credit analysis and fraud detection are the most implemented areas, using algorithms such as random forests (RF), decision trees (DT), support vector machines (SVM), and logistic regression (LR), among others. In addition, their use brings significant benefits for decision-making and optimizing banking operations. However, the handling of substantial amounts of data with these technologies poses ethical challenges.
Use of Thick Maximum‐Intensity Projection Brain Computed Tomography Angiography for Evaluation of Baseline Collateral Status Improves Interrater Agreement
Authors: Al‐Shamrani Mohamed A. , Bin Amir Hussain , Alotaibi Fawaz F. , Mohamed Gamal , Alokaili Riyadh N. , Al‐Kawi Ammar , Alreshaid Abdulrahman A. , Al‐Zawahmah Mohamed , Al‐Hazzani Adel , Demchuk Andrew M. , Shuaib Ashfaq , Al‐Ajlan Fahad S. 
Published: November 2023

Background
In acute ischemic stroke caused by large‐vessel occlusion, tissue viability is dependent on the blood supply from leptomeningeal collaterals until reperfusion is achieved. Rapid and accurate evaluation of baseline collateral status is a key marker of eligibility for endovascular therapy but can be challenging to interpret using source images of the computed tomography angiography (SI‐CTA). Our objective was to assess whether the use of thick maximum‐intensity projection computed tomography angiography (MIP‐CTA) improves interrater agreement for evaluation of baseline collaterals status between stroke trainees and an expert stroke neurologist.

Methods
An expert stroke neurologist and 2 stroke trainees independently reviewed images from 40 brain CTA scans with anterior circulation large‐vessel occlusion and assessed collateral status using the Tan collateral scoring system using SI‐CTA in the first reading and then using MIP‐CTA in the second reading. We calculated interrater agreement and recorded the total time needed in each reading.

Results

Interrater agreement was fair between the 2 stroke fellows and stroke expert when using SI‐CTA (κ=0.45 with 52.5% agreement). After using MIP‐CTA, interrater agreement improved to moderate (κ=0.69 with 70% agreement). The median reading time was 1.89 minutes per scan using SI‐CTA and 1.00 minute per scan using MIP‐CTA (
P
<0.0001).

Conclusions
We show that using MIP‐CTA, when compared with SI‐CTA, shortens interpretation time and improves interrater agreement between stroke trainees and a stroke imaging expert for the evaluation of baseline collaterals in patients presenting with anterior circulation large‐vessel occlusion.
An Issue of Intercultural Communication: An Unknown Letter from the “Sultan of Babylon” to Pope Innocent VIII
Authors: Tafiłowski Piotr 
Published: November 2023

Abstract
In the University of Glasgow Library’s copy of Pius II’s Epistolae familiares (Nuremberg: Anton Koberger, 16 Sept. 1481), recorded on leaf 1–1v one can find a copy of a letter addressed to Pope Innocent VIII that starts with the heading “Soldanus pontifici Romano pro Restauracione Iunioris filii senioris Turchi”. The letter’s sender, who is referred to in the text as the “Sultan of Babylon”, was the Caliph of Cairo, al-Mutawakkil II (Abdul Aziz ibn Yaʿqub ibn Muhammad). The present text discusses the content of the letter and the issues regarding the question of its authorship. To ensure a comprehensive presentation of the argumentation, the paper not only discusses the content of the letter but also explores the wider context in which it was produced, situating it against the wider history of the Mamluk state and Mamluk diplomacy as well as the late medieval tradition of the exchange of correspondence (both real and fictitious) between the Christian and Muslim worlds. It needs underlining that not only has the content of the letter in question hitherto been substantially unknown to scholars, but the letter is furthermore the first discovered correspondent from an ʿAbbasid Caliph sent to the head of Western Christianity.
The paper offers a contribution to research on intercultural communication.
The paper comes with three appendices: a transliteration and a translation of the letter and a facsimile of the original record.
Continuity and Change at Millennial Scale: The Holy Sites of Serindia
Authors: Thum Rian 
Published: November 2023

Abstract
This essay offers an experiment in chronological boundary crossing as way of addressing questions about continuity and change in Central Eurasia. It analyzes the violent transformations of holy sites in Altishahr (more widely known as Eastern Turkistan or southern Xinjiang), examining the 11th-century transition from Buddhist to Muslim rule alongside the 21st-century efforts of the People’s Republic of China to transform sacred Islamic sites into nationalist showpieces and “Silk Road” tourism sites. This juxtaposition calls into question prevailing understandings of the 11th -century transition as a simple refashioning of existing Buddhist sites into Islamic forms, while also placing current Chinese restrictions on Islamic holy sites in a broader historical perspective. Together, these 11th- and 20th century transformations show that shrines act as cultural arbiters, establishing routes by which change has entered Altishahr and stubbornly preserving not just older meanings, but also older ways of knowing. At the same time, they are places where the dynamics of continuous meaning creation come into clear view—where cultural change itself becomes an explicit part of the narratives that bind people together in supposedly stable identity groups such as religions and nations.
The Right to Adequate Housing & brics
Authors: Vols Michel , Hoogenhout Isabella , Schaetzel Max , Schubert Lea 
Published: November 2023

Abstract
This paper analyses the implementation of the right to adequate housing in Brazil, China, and Russia, which are part of the brics group of countries. The study reveals that while Brazil and Russia have legally recognised the right to housing through domestic law and multinational human rights treaties, China has been less willing to do so. Even when international instruments have been implemented, they have not always successfully ensured state accountability for housing rights violations, and few cases have been brought under individual complaint procedures. This study highlights common housing issues faced by each jurisdiction in the practical implementation of the right to housing, which are similar to those encountered by other countries but are often more severe due to the economic, political, and historical circumstances of the countries under review.
Witnessing Colonial Warfare in Early-20th Century Portugal: The Photographic Reportage of the Kwamato Campaign in South Angola (1907)
Authors: Silveira Pereira Hugo 
Published: November 2023

Abstract
In 1907, a Portuguese military expedition was sent to Angola to subdue the Kwamato. Two photographers accompanied the troops and photographed moments of rest, training, and combat. It was the first Portuguese photographic reportage of war. This article analyses a group of photographs of the Kwamato campaign as an example of photography of war. Using a methodology based on discourse analysis in journalism, this article illustrates how photography represented colonial warfare as part of a narrative of imperial dominance where modern technology was crucial, and how this representation was presented and normalised to the Portuguese mainland public in the illustrated press.
A Deep Learning Model for Precipitation Nowcasting Using Multiple Optical Flow Algorithms
Authors: Ha Ji-Hoon , Lee Hyesook 
Published: November 2023

Abstract
The optical flow technique has advantages in motion tracking and has long been employed in precipitation nowcasting to track the motion of precipitation fields using ground radar datasets. However, the performance and forecast time scale of models based on optical flow are limited. Here, we present the results of the application of the deep learning method to optical flow estimation to extend its forecast time scale and enhance the performance of nowcasting. It is shown that a deep learning model can better capture both multispatial and multitemporal motions of precipitation events compared with traditional optical flow estimation methods. The model comprises two components: 1) a regression process based on multiple optical flow algorithms, which more accurately captures multispatial features compared with a single optical flow algorithm; and 2) a U-Net-based network that trains multitemporal features of precipitation movement. We evaluated the model performance with cases of precipitation in South Korea. In particular, the regression process minimizes errors by combining multiple optical flow algorithms with a gradient descent method and outperforms other models using only a single optical flow algorithm up to a 3-h lead time. Additionally, the U-Net plays a crucial role in capturing nonlinear motion that cannot be captured by a simple advection model through traditional optical flow estimation. Consequently, we suggest that the proposed optical flow estimation method with deep learning could play a significant role in improving the performance of current operational nowcasting models, which are based on traditional optical flow methods.

Significance Statement
The purpose of this study is to improve the accuracy of short-term rainfall prediction based on optical flow methods that have been employed for operational precipitation nowcasting. By utilizing open-source libraries, such as OpenCV, and commonly applied machine learning techniques, such as multiple linear regression and U-Net networks, we propose an accessible model for enhancing prediction accuracy. We expect that the improvement in prediction accuracy will significantly improve the practical application of operational precipitation nowcasting.
Death Anxiety in Obsessive-Compulsive Disorders
Authors: Becker Sarah , Lee-Grimm Sie-In , Juckel Georg , Mavrogiorgou Paraskevi 
Published: November 2023

Objective: Death anxiety has long been attributed a role as a psychopathologically decisive factor in the development of mental illnesses such as obsessive-compulsive disorder (OCD). For example, patients with washing compulsions associate their behavior with a fear of life-threatening diseases or patients with control compulsions report that the constant checking is driven by the fear of fatal or deadly consequences for the occupants. Method: The Bochum Questionnaire to Assess Death Anxiety and Attitudes Towards Death (BOFRETTA) was administered to 31 patients with OCD and 31 healthy volunteers within a semi-structured interview using broad psychometry. Results: OCD patients showed increased death anxiety and negative attitute to death in comparison to healthy volunteers. A significant correlation was found between BOFRETTA-anxiety and the currently present religious obsessive thoughts. Conclusions: Our investigation provides further findings on the role of death anxiety and the problematic attitude towards death in OCD patients.