bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of postoperative hypersensitivity between Total-etch and Universal adhesive system: a randomized clinical trial
Authors: Javed Kiran , Noor Nouman , Nasir Muhammad Zubair , Manzoor Manzoor Ahmed 
Published: January 2024

AbstractThe objective was to determine the postoperative hypersensitivity of two-step Total-etch as compared to one-step Universal adhesives followed by composite restorations on 100 patients by applying Total-etch on one tooth and Universal adhesive on another tooth. The bonds and teeth were randomly selected. Postoperative hypersensitivity was recorded by visual analog scale before, immediately after, and 24 h after the restoration using cold stimulus. The Mann–Whitney test was applied for statistical comparison of postoperative hypersensitivity between the two bonds as well as for any significant difference in genders with each bond. No significant difference was found between postoperative hypersensitivity of the two adhesives before (p-value = 0.57), immediately after (p-value = 0.604), and 24 h after (p-value = 0.728) the restoration. Males showed more hypersensitivity with Total-etch as compared to females before (p-value = 0.037), immediately after (p-value = 0.047), and 24 h after the restoration (p-value = 0.022). No significant difference was found between gender and Universal adhesive at all three stages (p-value > 0.05). The results suggest no significant difference in postoperative hypersensitivity between the two materials when good sample size and proper technique were observed along with the removal of bias like different patients having different pain perceptions and multiple operators having different operating skills. Males showed more hypersensitivity to Total-etch.Trial registration number: Australian New Zealand Clinical Trials. Registry number: ACTRN12622001213730. (Retrospectively registered: 09/09/2022).
Evaluation of rock and fluid intermolecular interaction between asphaltene and sand minerals using electrochemical, analytical spectroscopy and microscopy techniques
Authors: Taheri-Shakib Jaber , Esfandiarian Ali , Rajabi-Kochi Mahyar , Kazemzadeh Ezzatallah , Afkhami Karaei Mohammad 
Published: January 2024

AbstractLong-time contact of heavy crude oil with rock leads to an adsorption phenomenon, which causes the rock surface to become oil-wet and appears as a barrier to the fluid flow in the porous media. However precise understanding of how asphaltene fractions influence sand wettability is lacking. The wetness of neat and asphaltene-aged sandstone was calculated using two relative permeability and contact angle methods. Then the molecular interaction between asphaltene and sand minerals was systematically analyzed using Fourier-transform infrared spectroscopy. Furthermore, the zeta potential was representative of electrostatic properties and surface charge alteration of the sand after these phenomena. Scanning electron microscopy with energy-dispersive X-ray (EDX) analysis also showed elemental mapping and dispersion of asphaltene particles on the rock surface. According to contact angle and EDX analyses of asphaltene samples, the contact angle rises from 115° to 141° by an increase in carbon adsorption on the sand surface from 8.23 to 41.56%. Spectroscopy results demonstrated that hydrogen-bonding, π-bonding, and sulfur-containing compounds such as sulfoxide improve asphaltene adsorption onto the sand surface. The higher the aromaticity index and hydrogen potential index of asphaltene, the greater the ability of asphaltene to change wettability. Adsorption of surface active components would make the surface charge of the sand more negative. The presence of nitrogen/sulfur-containing functional groups on the sand surface changed the electrostatic properties, as a sand surface coated with asphaltene would reduce the percentage of metal cations.
Axially lattice-matched wurtzite/rock-salt GaAs/Pb1−xSnxTe nanowires
Authors: Dad Sania , Dziawa Piotr , Zajkowska-Pietrzak Wiktoria , Kret Sławomir , Kozłowski Mirosław , Wójcik Maciej , Sadowski Janusz 
Published: January 2024

AbstractWe investigate the full and half-shells of Pb1−xSnxTe topological crystalline insulator deposited by molecular beam epitaxy on the sidewalls of wurtzite GaAs nanowires (NWs). Due to the distinct orientation of the IV–VI shell with respect to the III–V core the lattice mismatch between both materials along the nanowire axis is less than 4%. The Pb1−xSnxTe solid solution is chosen due to the topological crystalline insulator properties above some critical concentrations of Sn (x ≥ 0.36). The IV–VI shells are grown with different compositions spanning from binary SnTe, through Pb1−xSnxTe with decreasing x value down to binary PbTe (x = 0). The samples are analysed by scanning transmission electron microscopy, which reveals the presence of (110) or (100) oriented binary PbTe and (100) Pb1−xSnxTe on the sidewalls of wurtzite GaAs NWs.
Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis
Authors: Jin Zirun , Cao Yalei , Wen Qi , Zhang Haitao , Fang Zhuofan , Zhao Qiancheng , Xi Yu , Luo Zhichao , Jiang Hui , Zhang Zhe , Hang Jing 
Published: January 2024

AbstractMale infertility is one of the most common complications of diabetes mellitus (DM). Dapagliflozin is widely used to manage the type II DM. This study aimed to assess the dapagliflozin’s effects on the spermatogenesis by administering either dapagliflozin (Dapa) or vehicle (db) to male db/db mice, and using littermate male db/m mice as the control (Con). We further performed the integrative analyses of the cecal shotgun metagenomics, cecal/plasmatic/testicular metabolomics, and testicular proteomics. We found that dapagliflozin treatment significantly alleviated the diabetes-induced spermatogenic dysfunction by improving sperm quality, including the sperm concentration and sperm motility. The overall microbial composition was reshaped in Dapa mice and 13 species (such as Lachnospiraceae bacterium 3–1) were regarded as potential beneficial bacteria. Metabolites exhibited modified profiles, in which adenosine, cAMP, and 2′-deoxyinosine being notably altered in the cecum, plasma, and testis, respectively. Testicular protein expression patterns were similar between the Dapa and Con mice. In vivo results indicated that when compared with db group, dapagliflozin treatment alleviated apoptosis and oxidative stress in testis tissues by down-regulating 2′-deoxyinosine. This was further validated by in vitro experiments using GC-2 cells. Our findings support the potential use of dapagliflozin to prevent the diabetes-induced impaired sperm quality and to treat diabetic male infertility.
Optical absorbance profilometry for tracking time-resolved particle redistribution in high volume fraction colloidal droplets
Authors: Bhatt Sheila J. , Routh Alexander F. 
Published: January 2024

AbstractThe distribution of components within colloidal suspensions is important in many complex biological and industrial fluids. A convenient method of measuring such distributions in low-volume-fraction suspensions is that of optical absorbance. Here we introduce a time-dependent validity criterion allowing extended use of optical absorbance to track colloidal distribution in high volume fraction suspensions. We define our validity criterion and show its use on a range of volume fractions from 15 to 55%, and also on larger micron sized particles, common for biological cells. Within the validity criterion, we establish the evaporative time duration in which the material’s intrinsic coefficient of extinction can be treated as constant. This method enables rapid, low-cost, time-based study of the advective flow of suspended particulates, enabling advection to be straightforwardly measured from digital imaging. The residue profile predicted using our method in two test systems is compared with conventional laser profilometry measurements of the final evaporated residue, with good agreement at most radial positions.
Pioneering predictions of AKI and AKIN severity in burn patients: a comprehensive CBC approach
Authors: Park Jongsoo , Kym Dohern , Kim Myongjin , Cho Yong Suk , Hur Jun , Chun Wook , Yoon Dogeon , Yoon Jaechul 
Published: January 2024

AbstractThis study aims to evaluate the utility of complete blood count (CBC) markers, in conjunction with the acute kidney injury network (AKIN) criteria, for the early detection, severity assessment, and prediction of mortality outcomes of acute kidney injury (AKI) in burn patients. The research seeks to fill existing gaps in knowledge and validate the cost-effectiveness of using CBC as a routine diagnostic tool for better management of AKI. The study was conducted at Hangang Sacred Heart Hospital. We performed a large-scale retrospective analysis of 2758 adult patients admitted to the burn intensive care unit over a 12-year period. Among these patients, AKI occurred in 1554 patients (56.3%). Based on the AKIN stage classification, 794 patients (28.8%) were categorized as AKIN 1, 494 patients (17.9%) as AKIN 2, and 266 patients (9.6%) as AKIN 3. We defined several ratio markers, including the Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and various mean platelet volume (MPV) ratios. Our statistical analyses, conducted using the R programming language, revealed significant correlations between these markers and AKI severity. The AUC values for neutrophil count and WBC count were 0.790 and 0.793, respectively, followed by immature granulocyte count with an AUC of 0.727. For red blood cell (RBC)-related parameters, the AUC values for hematocrit (Hct), hemoglobin (Hb), and RBC count were 0.725, 0.713, and 0.713, respectively. Among the platelet-related parameters, only platelet distribution width (PDW) had an AUC of 0.677. Among the ratio markers, the NLR had the highest AUC at 0.772, followed by MPVNR and SII with AUC values of 0.700 and 0.680, respectively. The findings underscore the potential of CBC as an economical, routine test for AKI, thereby paving the way for enhanced patient outcomes. Our study suggests the utility of routine CBC tests, specifically WBC count and PLR, for predicting AKI and platelet, MPV, and NLR for mortality assessment in burn patients. These findings underscore the potential of easily accessible CBC tests in enhancing AKI management. However, further multicenter studies are needed for validation.
Perceived interpersonal distance changes in young Taiwanese pre and post SARS-CoV-2 pandemic
Authors: Chen Yi-Lang , Lee Yu-Chi , Hsu Che-Wei , Rahman Andi 
Published: January 2024

AbstractThe persistent SARS-CoV-2 pandemic, spanning over three years, has profoundly impacted daily life worldwide. Crucial measures like interpersonal distance (IPD) and mask-wearing have become paramount in preventing infection. With SARS-CoV-2 now resembling an endemic condition similar to influenza, it is vital to assess the changes in IPD influenced by relevant factors during and after the pandemic. This study concentrated on two specific stages (the pandemic stage and the post-pandemic era) and investigated variations in IPD with different test combinations. Variables taken into account encompassed the pandemic stage, participant gender, target gender, and mask-wearing status. We examined IPD data from 100 young individuals (50 males and 50 females) at each stage, with a one-year interval between tests. The results highlighted the substantial impact of all variables on perceived IPD during the pandemic phase (all p < 0.001). However, in the post-pandemic stage, only mask-wearing demonstrated a notable effect on IPD (p < 0.001). As the SARS-CoV-2 epidemic subsides, the enduring influence of mask usage on IPD persists. Nevertheless, the gap between the two mask-wearing scenarios diminishes, contracting from around 50 cm during the epidemic phase to 20 cm in the post-epidemic phase. Across these two pandemic stages, there was an overall reduction of approximately 90 cm in IPD, indicating a noteworthy decrease in perceived personal space and a consequential shortening of social proximity during the post-pandemic stage. This decrease in IPD may suggest the successful socio-cultural adaptation of the young Taiwanese individuals in our study during the post-pandemic era.
Psychometric evaluation of an adult post-COVID-19 symptom tool: a development and validation study
Authors: Kuo Po-Yuan , Chen Ping-Ho , Tsai Shu-Feng , Lin Wan-Ling , Hung Chia-Tai , Huang Sheng-Miauh 
Published: January 2024

AbstractThe objective of this study was aimed to develop and validate an instrument for post-COVID-19 symptoms in adults. Data were collected from adults with a previous COVID-19 diagnosis in Taiwan. We developed the initial instrument through systematic review and expert feedback. Its validity was tested using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and criterion-related validity, while its reliability was tested using Cronbach’s alpha. In total, 310 adults participated in this study. Examination of the EFA clearly classified a five-factor model with 24 items (Kaiser–Meyer–Olkin = 0.903; Bartlett’s test of sphericity: X2 = 5242.956, df = 276, p < 0.01). The goodness of fit indices of the CFA were as follows: chi-square = 635.172 (p < 0.01), normed chi-square = 2.669, standardized root mean square residual = 0.077, root mean square error of approximation = 0.073, comparative fit index = 0.922, and Tuker and Lewis index = 0.910. The value of Cronbach’s alpha coefficient for the total items was 0.941, and the values for the subscales ranged from 0.813 to 0.924. The instrument exhibited acceptable psychometric properties, proving it to be a valuable tool for evaluating post-COVID-19 symptoms in patients at hospitals.
Social visual attention as a treatment outcome: evaluating the social games for autistic adolescents (SAGA) intervention
Authors: Scherf K. Suzanne , Griffin Jason W. , Geier Charles F. , Smyth Joshua M. 
Published: January 2024

AbstractA core feature of autism involves difficulty perceiving and interpreting eye gaze shifts as nonverbal communicative signals. A hypothesis about the origins of this phenotype is that it emerges from developmentally different social visual attention (SVA). We developed Social Games for Autistic Adolescents (SAGA; Scherf et al. BMJ Open 8(9):e023682, 2018) as a serious game intervention for autistic individuals to discover the significance of eye gaze cues. Previously, we demonstrated the effectiveness of SAGA to improve the perception and understanding of eye gaze cues and social skills for autistic adolescents (Griffin et al. JCPP Adv 1(3):e12041, 2021). Here, we determine whether increases in social visual attention to faces and/or target gazed-at objects, as measured via eye tracking during the same Gaze Perception task in the same study sample, moderated this improvement. In contrast to predictions, SVA to faces did not differentially increase for the treatment group. Instead, both groups evinced a small increase in SVA to faces over time. Second, Prior to the SAGA intervention, attention to faces failed to predict performance in the Gaze Perception task for both the treatment and standard care control groups. However, at post-test, autistic adolescents in the treatment group were more likely to identify the object of directed gaze when they attended longer to faces and longer to target objects. Importantly, this is the first study to measure social visual attention via eye tracking as a treatment response in an RCT for autism. NCT02968225
Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer’s disease
Authors: Kivisäkk Pia , Fatima Hadia A. , Cahoon Danielle S. , Otieno Brunah , Chacko Leena , Minooei Farnaz , Demos Catherine , Stengelin Martin , Sigal George , Wohlstadter Jacob , Arnold Steven E. 
Published: January 2024

AbstractA growing literature suggests that plasma levels of tau phosphorylated at amino acid 217 (pTau217) performs similarly to cerebrospinal fluid (CSF) biomarkers and PET imaging to detect amyloid pathology and to provide diagnostic and prognostic information in Alzheimer’s disease (AD), but a significant limiting factor thus far has been a lack of widely available immunoassays. We evaluated a novel pTau217 S-PLEX® assay developed by Meso Scale Discovery (MSD; Rockville, MD) in plasma from 131 individuals with AD confirmed by CSF biomarkers and controls. Technical performance of the assay was excellent with an LLOQ of 1.84 pg/mL and intra/interplate CVs of 5.5% (0.3–15.0%) and 5.7% (range 0.3–13.4%), respectively. The pTau217 plasma assay differentiated AD and controls with an AUC of 0.98 (95% CI 0.96–1.0) and pTau217 levels were 3.9-fold higher in individuals with AD. This performance was significantly better than what was observed for plasma pTau181, performed in parallel, and comparable to published data on existing pTau217 assays. While further clinical validation and head-to-head comparisons are needed to fully establish the role for the novel pTau217 S-PLEX assay, these data demonstrate the utility of the assay to detect AD pathology.
Derailed protein turnover in the aging mammalian brain
Authors: Rao Nalini R , Upadhyay Arun , Savas Jeffrey N 
Published: January 2024

AbstractEfficient protein turnover is essential for cellular homeostasis and organ function. Loss of proteostasis is a hallmark of aging culminating in severe dysfunction of protein turnover. To investigate protein turnover dynamics as a function of age, we performed continuous in vivo metabolic stable isotope labeling in mice along the aging continuum. First, we discovered that the brain proteome uniquely undergoes dynamic turnover fluctuations during aging compared to heart and liver tissue. Second, trends in protein turnover in the brain proteome during aging showed sex-specific differences that were tightly tied to cellular compartments. Next, parallel analyses of the insoluble proteome revealed that several cellular compartments experience hampered turnover, in part due to misfolding. Finally, we found that age-associated fluctuations in proteasome activity were associated with the turnover of core proteolytic subunits, which was recapitulated by pharmacological suppression of proteasome activity. Taken together, our study provides a proteome-wide atlas of protein turnover across the aging continuum and reveals a link between the turnover of individual proteasome subunits and the age-associated decline in proteasome activity.
Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1
Authors: Torella Laura , Klermund Julia , Bilbao-Arribas Martin , Tamayo Ibon , Andrieux Geoffroy , Chmielewski Kay O , Vales Africa , Olagüe Cristina , Moreno-Luqui Daniel , Raimondi Ivan , Abad Amaya , Torrens-Baile Julen , Salido Eduardo , Huarte Maite , Hernaez Mikel , Boerries Melanie , Cathomen Toni , Zabaleta Nerea , Gonzalez-Aseguinolaza Gloria 
Published: January 2024

AbstractThe therapeutic use of adeno-associated viral vector (AAV)-mediated gene disruption using CRISPR-Cas9 is limited by potential off-target modifications and the risk of uncontrolled integration of vector genomes into CRISPR-mediated double-strand breaks. To address these concerns, we explored the use of AAV-delivered paired Staphylococcus aureus nickases (D10ASaCas9) to target the Hao1 gene for the treatment of primary hyperoxaluria type 1 (PH1). Our study demonstrated effective Hao1 gene disruption, a significant decrease in glycolate oxidase expression, and a therapeutic effect in PH1 mice. The assessment of undesired genetic modifications through CIRCLE-seq and CAST-Seq analyses revealed neither off-target activity nor chromosomal translocations. Importantly, the use of paired-D10ASaCas9 resulted in a significant reduction in AAV integration at the target site compared to SaCas9 nuclease. In addition, our study highlights the limitations of current analytical tools in characterizing modifications introduced by paired D10ASaCas9, necessitating the development of a custom pipeline for more accurate characterization. These results describe a positive advance towards a safe and effective potential long-term treatment for PH1 patients.
Small‐gain based stabilizing control for hybrid systems: Application to bipedal walking robot
Authors: Khademian Fatemeh , Rahmani Mehdi 
Published: January 2024

AbstractThis study presents a systematic methodology for developing a stabilizing controller for a general hybrid systems model. The approach is based on utilizing the small‐gain theorem as a means of constructing the Lyapunov function and analyzing the input–output stability of the subsystems in the feedback loop. By considering the control system in a closed‐loop configuration with the hybrid system, the small‐gain theorem can be applied. In this scheme, a dynamic control system is proposed that satisfies the closed‐loop stability conditions. This method applies to various hybrid systems' applications due to its generality. To demonstrate the effectiveness and performance of the proposed control approach, two simulation examples, including a linear hybrid system and a bipedal walking robot, are examined.
Dynamic load altering attack detection based on adaptive fading Kalman filter in smart grid
Authors: Li Jian , Sun Chaowei , Yang Shuxian , Su Qingyu 
Published: January 2024

AbstractThis paper mainly studies a detection method of dynamic load altering attacks (D‐LAAs) in smart grids. First, communication factors are considered, and a smart grid discrete system model under D‐LAA attack is established. Second, for closed‐loop D‐LAAs, an adaptive fading Kalman filter (AFKF) is designed to estimate the states of smart grids with Gaussian noise in real time, and a Euclidean distance ratio detection algorithm based on AFKF is proposed to detect D‐LAAs. Moreover, the proposed detection algorithm can identify D‐LAAs even in the presence of noise in the measurement data, significantly enhancing the speed of attack detection. Finally, take a smart grid with three generators and six buses as an example. Its feasibility and effectiveness of the Euclidean distance ratio detection algorithm are verified by simulations. The simulations are carried out through the real‐time hardware‐in‐the‐loop simulation platform, which is mainly composed of StarSim and multi‐tasking devices.
Dissecting The Analects: an NLP-based exploration of semantic similarities and differences across English translations
Authors: Yang Liwei , Zhou Guijun 
Published: January 2024

AbstractThe Analects, a classic Chinese masterpiece compiled during China’s Warring States Period, encapsulates the teachings and actions of Confucius and his disciples. The profound ideas it presents retain considerable relevance and continue to exert substantial influence in modern society. The availability of over 110 English translations reflects the significant demand among English-speaking readers. Grasping the unique characteristics of each translation is pivotal for guiding future translators and assisting readers in making informed selections. This research builds a corpus from translated texts of The Analects and quantifies semantic similarity at the sentence level, employing natural language processing algorithms such as Word2Vec, GloVe, and BERT. The findings highlight semantic variations among the five translations, subsequently categorizing them into “Abnormal,” “High-similarity,” and “Low-similarity” sentence pairs. This facilitates a quantitative discourse on the similarities and disparities present among the translations. Through detailed analysis, this study determined that factors such as core conceptual words, and personal names in the translated text significantly impact semantic representation. This research aims to enrich readers’ holistic understanding of The Analects by providing valuable insights. Additionally, this research offers pragmatic recommendations and strategies to future translators embarking on this seminal work.