bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Novel Acetyl‐11‐keto‐β‐boswellic Acid Derivatives as Potential Anti‐GBM Agents
Authors: Sun Mingxia , Zhang Sen , Wang Jinhua , Du Guanhua , Ji Tengfei 
Published: February 2024

AbstractAcetyl‐11‐keto‐β‐boswellic acid (AKBA) is known to inhibit the growth of glioblastoma (GBM) cells and subcutaneous GBM. A series of acetyl‐11‐keto‐β‐boswellic acid (AKBA) derivatives containing the oxime‐ester functionality or amide side chains were synthesized, and their anti‐GBM activities were evaluated. Some of these compounds exhibited significant inhibitory activity against cell proliferation in U87 and U251 GBM cell lines, with IC50 values in the micromolar concentration range. Cellular thermal shift analysis showed that A‐01 and A‐10 improved the thermal stability of FOXM1, indicating that these highly active compounds may directly bind to FOXM1 in cells. Docking studies of the two most active compounds, A‐01 and A‐10, revealed key interactions between these compounds and the active site of FOXM1, in which the amide moiety at the C‐24 position was essential for improving the activity. These results suggested that A‐10 is a suitable lead molecule for the development of FOXM1 inhibitors. Thus, the rational design of AKBA derivatives with amide side chains holds significant potential for discovering of a new class of triterpenoids capable of inhibiting GBM cell proliferation.
A case of MYH7 and MYH9 genes variants with cardiomyopathy and macrothrombocytopenia
Authors: Ikawa Yasuhiro , Nakamura Taichi , Fujino Noboru , Uchiyama Toru , Ishiguro Akira , Takenaka Mika , Sakai Yuta , Noguchi Kazuhiro , Fujiki Toshihiro , Wada Taizo 
Published: February 2024

Key Clinical Message.A 15‐year‐old girl developed inherited cardiomyopathy and macrothrombocytopenia revealing pathogenic variants of both MYH7 and MYH9 genes. This underlies the importance of repeated genetic testing in diagnosing and managing inherited disorders.AbstractThe MYH7 and MYH9 genes encode for distinct myosin heavy chain proteins. Our case features a 15‐year‐old girl, presenting with inherited cardiomyopathy and macrothrombocytopenia, revealing distinct pathogenic variants of both MYH7 and MYH9 genes. This underlines the relevance of genetic testing and personalized medicine in diagnosing and managing inherited disorders.
Oxidative Decarbonylation of an Azacalixpyridine‐Supported Mo(0)‐Tricarbonyl to a Mo(VI)‐Trioxo Complex with Dioxygen in Solution and on Au(111): Determination of Molecular Mechanism
Authors: Clausen Kai Uwe , Pienack Nicole , Gripp Joachim , Tuczek Felix 
Published: February 2024

AbstractThe conversion of an azacalixpyridine‐supported Mo(0) tricarbonyl into a Mo(VI) trioxo complex with dioxygen (O2) is investigated in homogeneous solution and in a molecular film adsorbed on Au(111) using a variety of spectroscopic and analytical methods. These studies in particular show that the dome‐shaped carbonyl complex adsorbed on the metal surface has the ability to bind and activate gaseous oxygen, overcoming the so‐called surface trans‐effect. Furthermore, the rate of the conversion dramatically increases by irradiation with light. This observation is explained with the help of complementary DFT calculations and attributed to two different pathways, a thermal and a photochemical one. Based on the experimental and theoretical findings, a molecular mechanism for the conversion of the carbonyl to the oxo complex is derived.
Pinpointing Acidic Residues in Proteins
Authors: Xuan Weimin , Ma Jun‐An 
Published: February 2024

AbstractIt is of great importance to pinpoint specific residues or sites of a protein in biological contexts to enable desired mechanism of action for small molecules or to precisely control protein function. In this regard, acidic residues including aspartic acid (Asp) and glutamic acid (Glu) hold great potential due to their great prevalence and unique function. To unlock the largely untapped potential, great efforts have been made recently by synthetic chemists, chemical biologists and pharmacologists. Herein, we would like to highlight the remarkable progress and particularly introduce the electrophiles that exhibit reactivity to carboxylic acids, the light‐induced reactivities to carboxylic acids and the genetically encoded noncanonical amino acids that allow protein manipulations at acidic residues. We also comment on certain unresolved challenges, hoping to draw more attention to this rapidly developing area.
Chemovoltaic effect for renewable liquid and vapor fuels on semiconductor surfaces
Authors: Alizadeh Mahdi , Radevici Ivan , Li Shengyang , Oksanen Jani 
Published: February 2024

AbstractThe chemovoltaic effect – generation of electronic excitation by exergonic redox reactions – has been observed on metallic surfaces of Schottky junctions and is proving to be pivotal in explaining in detail the momentum conservation relations of chemically active collisions. As shown in this work, it can hold keys for direct chemical energy harvesting by semiconductor solar cells. To study the possibilities of chemovoltaic energy conversion by semiconductors, we have modeled and designed an ‘electrolyte‐free fuel cell’ formed by a GaAs diode that can host electrochemical fuel oxidation and oxidant reduction reactions on its conduction and valence bands and as a result convert renewable chemical energy (as well as light) into electricity. The experimental results show that exposing the surface of a suitably designed solar cell to methanol liquid or vapor in the presence of oxygen or hydrogen peroxide leads to the generation of electrical power.
TreeViewer: Flexible, modular software to visualise and manipulate phylogenetic trees
Authors: Bianchini Giorgio , Sánchez‐Baracaldo Patricia 
Published: February 2024

AbstractPhylogenetic trees illustrate evolutionary relationships between taxa or genes. Tree figures are crucial when presenting results and data, and by creating clear and effective plots, researchers can describe many kinds of evolutionary patterns. However, producing tree plots can be a time‐consuming task, especially as multiple different programs are often needed to adjust and illustrate all data associated with a tree. We present TreeViewer, a new software to draw phylogenetic trees. TreeViewer is flexible, modular, and user‐friendly. Plots are produced as the result of a user‐defined pipeline, which can be finely customised and easily applied to different trees. Every feature of the program is documented and easily accessible, either in the online manual or within the program's interface. We show how TreeViewer can be used to produce publication‐ready figures, saving time by not requiring additional graphical post‐processing tools. TreeViewer is freely available for Windows, macOS, and Linux operating systems and distributed under an AGPLv3 licence from https://treeviewer.org. It has a graphical user interface (GUI), as well as a command‐line interface, which is useful to work with very large trees and for automated pipelines. A detailed user manual with examples and tutorials is also available. TreeViewer is mainly aimed at users wishing to produce highly customised, publication‐quality tree figures using a single GUI software tool. Compared to other GUI tools, TreeViewer offers a richer feature set and a finer degree of customisation. Compared to command‐line‐based tools and software libraries, TreeViewer's graphical interface is more accessible. The flexibility of TreeViewer's approach to phylogenetic tree plotting enables the program to produce a wide variety of publication‐ready figures. Users are encouraged to create their own custom modules to expand the functionalities of the program. This sets the scene for an ever‐expanding and ever‐adapting software framework that can easily adjust to respond to new challenges.
Temporal variations in female moose responses to roads and logging in the absence of wolves
Authors: Gagnon Mireille , Lesmerises Frédéric , St‐Laurent Martin‐Hugues 
Published: February 2024

AbstractAnimal movements, needed to acquire food resources, avoid predation risk, and find breeding partners, are influenced by annual and circadian cycles. Decisions related to movement reflect a quest to maximize benefits while limiting costs, especially in heterogeneous landscapes. Predation by wolves (Canis lupus) has been identified as the major driver of moose (Alces alces) habitat selection patterns, and linear features have been shown to increase wolf efficiency to travel, hunt, and kill prey. However, few studies have described moose behavioral response to roads and logging in Canada in the absence of wolves. We thus characterized temporal changes (i.e., day phases and biological periods) in eastern moose (Alces alces americana) habitat selection and space use patterns near a road network in a wolf‐free area located south of the St. Lawrence River (eastern Canada). We used telemetry data collected on 18 females between 2017 and 2019 to build resource selection functions and mixed linear regressions to explain variations in habitat selection patterns, home‐range size, and movement rates. Female moose selected forest stands providing forage when movement was not impeded by snow cover (i.e., spring/green‐up, summer/rearing, fall/rut) and stands offering protection against incidental predation during calving. In winter, home‐range size decreased with an increasing proportion of stands providing food and shelter against harsh weather, limiting the energetic costs associated with movement. Our results reaffirmed the year‐round aversive effect of roads, even in the absence of wolves, but the magnitude of this avoidance differed between day phases, being lower during the “dusk‐night‐dawn” phase, perhaps due to a lower level of human activity on and near roads. Female moose behavior in our study area was similar to what was observed in landscapes where moose and wolves cohabit, suggesting that the risk associated with humans, perceived as another type of predator, and with incidental predators (coyote Canis latrans, black bear Ursus americanus), equates that of wolf predation in heavily managed landscapes.
Transcatheter edge‐to‐edge repair in papillary muscle injury complicating acute myocardial infarction
Authors: Haberman Dan , Estévez‐Loureiro Rodrigo , Czarnecki Andrew , Denti Paolo , Villablanca Pedro , Spargias Konstantinos , Sudarsky Doron , Perl Leor , Fefer Paul , Manevich Lisa , Masiero Giulia , Nombela‐Franco Luis , Poles Lion , Caneiro‐Queija Berenice , Bowers Nicolas , Schiavi Davide , Tarantini Giuseppe , Melillo Francesco , Chrissoheris Michael , Dvir Danny , Maisano Francesco , Taramasso Maurizio , Shuvy Mony 
Published: February 2024

AbstractAimsAcute mitral regurgitation (MR) in the setting of myocardial infarction (MI) may be the result of papillary muscle rupture (PMR). This condition is associated with high morbidity and mortality. We aim to evaluate the feasibility of transcatheter edge‐to‐edge mitral valve repair (TEER) in this acute setting.Methods and resultsWe analysed data from the International Registry of MitraClip in Acute Mitral Regurgitation following acute Myocardial Infarction (IREMMI) of 30 centres in Europe, North America, and the middle east. We included patients with post‐MI PMR treated with TEER as a salvage procedure, and we evaluated immediate and 30‐day outcomes. Twenty‐three patients were included in this analysis (9 patients suffered complete papillary muscle rupture, 9 partial and 5 chordal rupture). The patients' mean age was 68 ± 14 years. Patients were at high surgical risk with median EuroSCORE II 27% (IQR 16, 28) and 20 out of 23 (87% were in cardiogenic shock). All patients were treated with vasopressors, and 17 out of 23 patients required mechanical support. TEER procedure was performed on the median 6 days after the index MI date IQR (3, 11). Procedural success was achieved in 87% of patients. The grade of MR was significantly decreased after the procedure. MR reduction to 0 or 1 + was achieved in 13 patients (57%), to 2 + in 7 patients (30%), P < 0.01. V‐Wave was reduced from 49 ± 8 mmHg to 26 ± 10 mmHg post‐procedure, P < 0.01. Sixteen out of 23 patients (70%) were discharged from hospital and 5 of them required reintervention with surgical mitral valve replacement. No additional death at 1 year was documented.ConclusionsTEER is a feasible therapy in critically ill patients with PMR due to a recent MI. TEER may have a role as salvage treatment or bridge to surgery in this population.
Fetch‐driven aeolian sediment transport on a sandy beach: A new study
Authors: Strypsteen Glenn , Delgado‐Fernandez Irene , Derijckere Jennifer , Rauwoens Pieter 
Published: February 2024

AbstractThis study examines the effect of fetch distance on aeolian sediment transport and the corresponding growth rate of aeolian transport rate on a sandy beach under varying wind speeds. Eight experiments were conducted on both dry and intertidal beach areas, with wind speeds ranging from 9 to 17 m/s. Vertically stacked sand traps were used to measure transport rates over distances up to 100 m, with experiments lasting 20–40 minutes. Results indicate an initial increase in transport rate until the critical fetch distance, followed by a subsequent decrease in sediment transport with further fetch distance. Critical fetch distances, corresponding to maximum transport rates, ranged from 23.8 to 103.5 m. A strong linear correlation was observed between wind speed and critical fetch distance, suggesting that higher wind speeds necessitate longer fetch distances for maximum transport. Furthermore, established formulations by van Rijn and Strypsteen are tested to estimate maximum sediment transport and critical fetch distance based on grain‐related shear velocity. Combining all experiments showed that the growth rate in transport up to the point of critical fetch can be best described by a trigonometric function. These findings contribute to a better understanding of the fetch effect on aeolian sediment dynamics in coastal sandy environments.
Digital accounting system and its effect on corporate governance: An empirical investigation
Authors: Al‐Hattami Hamood Mohammed , Almaqtari Faozi A. , Abdullah Abdulwahid Ahmed Hashed , Al‐Adwan Ahmad Samed 
Published: February 2024

AbstractThis empirical investigation explores the impact of the digital accounting system (DAS) on corporate governance (CG). The rapid advancement of technology has revolutionized various aspects of business operations, including accounting processes. The transition from traditional manual accounting systems to digital platforms has been accompanied by significant changes in corporate governance practices. This study aims to investigate the influence of DAS effectiveness (bookkeeping system, DAS security, IFRS adoption, and budgeting system) and the success of DAS (system quality, information quality, and service quality) on CG. The study determined the relationship by conducting a questionnaire survey of 264 senior managers, accountants, and department heads of pharmaceutical companies in Yemen. Partial Least Squares (PLS) was used for data analysis. The results supported all assumed relationships except the relationship between the budgeting system and CG. Specifically, unlike all supposed relationships, the budgeting system had no significant impact on CG. Despite the fact that prior studies have investigated these issues from different aspects in developed countries, the evidence in less developed countries is still unknown. Further, revisiting DAS and CG aspects with different new insights and measures, particularly bookkeeping system, DAS security, IFRS adoption, budgeting system, system quality, information quality, and service quality, has not been the subject of prior studies. As a result, the present study bridges a serious gap in the existing stock of knowledge in DAS and CG studies. Moreover, this piece of research has useful implications for managers, investors, practitioners, academicians, and decision‐makers.
Enhancing oil–water emulsion separation using improved styrene–acrylonitrile copolymer membrane: Experimental and thermodynamic study of the impact of solvent mixtures
Authors: Mohamadbeiki Ahmadreza , Ashtiani Farzin Zokaee , Karimi Mohammad , Hamta Afshin 
Published: February 2024

AbstractThis study investigated the fabrication of styrene–acrylonitrile copolymer (SAN) membrane using the nonsolvent‐induced phase separation (NIPS) method with a combination of solvents, namely N‐methyl‐2‐pyrrolidone (NMP) and dimethylformamide (DMF) and water as the nonsolvent. Since the impact of varying solvent ratios on SAN membrane performance remained unexplored, this study aimed to address this knowledge gap in the context of oil–water emulsion separation. Experimental results demonstrated that employing a solvent mixture, rather than a pure solvent, led to improved membrane performance. The primary objective of this work was to experimentally determine the optimal solvent ratio for enhancing SAN copolymer membrane performance. Additionally, the Flory–Huggins thermodynamic model was applied to investigate the possibility of predicting membrane binodal data. The thermodynamic analysis revealed a strong agreement between calculated and experimental binodal data, with an error of less than 3.8%. Notably, membranes produced with an equal solvent ratio exhibited the most hydrophilic properties, resulting in increased permeability. The permeate flux for distilled water reached 320 L/(m2 h) (LMH), and water contact angle of the membrane was 22°. Furthermore, mechanical resistance increased up to 50%. These results highlight the promising potential of fabricating SAN membrane using solvent mixtures for oil–water emulsion separation.
Salinity inhibits seed germination and embryo growth by reducing starch mobilization efficiency in barley
Authors: Xiong Min , Xu Jian , Zhou Zhou , Peng Bin , Shen Yuxiang , Shen Huiquan , Xu Xiao , Li Changya , Deng Lina , Feng Gongneng 
Published: February 2024

AbstractBarley is one of the world's earliest domesticated crops, which is widely used for beer production, animal feeding, and health care. Barley seed germination, particularly in increasingly saline soils, is key to ensure the safety of crop production. However, the mechanism of salt‐affected seed germination in barley remains elusive. Here, two different colored barley varieties were used to independently study the regulation mechanism of salt tolerance during barley seed germination. High salinity delays barley seed germination by slowing down starch mobilization efficiency in seeds. The starch plate test revealed that salinity had a significant inhibitory effect on α‐amylase activity in barley seeds. Further, NaCl treatment down‐regulated the expression of Amy1, Amy2 and Amy3 genes in germinated seeds, thereby inhibiting α‐amylase activity. In addition, the result of embryogenic culture system in vitro showed that the shoot elongation of barley was significantly inhibited by salt stress. These findings indicate that it is a feasible idea to study the regulation mechanism of salinity on barley seed germination and embryo growth from the aspect of starch‐related source‐sink communication.
Adaptive liquid crystal polymers based on dynamic bonds: From fundamentals to functionalities
Authors: Lan Ruochen , Hu Xiang‐Guo , Chen Jingyu , Zeng Xingping , Chen Xinyu , Du Tongji , Song Xinyue , Yang Huai 
Published: February 2024

AbstractLiquid crystal polymers (LCPs) have gained tremendous attention in recent years due to their great potentials from fabrication of responsive actuators and sensors to construction of intelligent soft robotic and light modulators. However, conventional LCPs with permanent cross‐links present tedious and unmodifiable stimuli‐responsiveness. Recently, dynamic bonds capable to reversibly break and reform have been integrated into LCP, imparting intrinsic dynamic characteristics. The dynamic LCP possesses unprecedented diverse functionalities including reprogrammability, recyclability, and self‐healing ability, becoming much more adaptive to surrounding environmental changes compared with the conventional counterpart. In this review, recent progress of dynamic bond‐based LCPs is summarized. The mechanism, preparation, and functionalities of dynamic LCPs based on dynamic noncovalent bond (DNCB) and dynamic covalent bond (DCB) are poised to be discussed, followed by introducing emergent LCPs combining both of DNCB and DCB. Consequently, the unique functionalities of dynamic bond‐based LCPs will be given. Finally, outlooks of development of the dynamic bond‐based LCPs are presented.
Cutaneous Manifestations of Myelodysplastic Syndrome: A Systematic Review
Authors: Tan Xiang Li , Vatopoulou Theodora , Siddique Amana , Kolovos Athena , Lamb Ruth C. , Fleming Charlotte , Ferguson Leila , Akhras Victoria , Jiyad Zainab 
Published: February 2024

Abstract
Myelodysplastic syndrome (MDS) may present with specific skin lesions, such as leukaemia cutis, which is a well known poor prognostic marker of leukaemia with a high risk of acute leukaemic transformation. However, less is known regarding non-specific cutaneous manifestations of MDS including the prevalence, types and their prognostic and therapeutic significance, which we aimed to determine through this systematic review. We searched electronic databases (PubMed, Medline and EMBASE) from inception up to 26 January 2023 for studies reporting cutaneous manifestations of MDS. Eighty eight articles (case reports n = 67, case series n = 21), consisting of 134 patients were identified. We identified 6 common cutaneous manifestations: neutrophilic dermatoses (n = 64), vasculitis (n = 21), granulomatous (n = 8), connective tissue disease (CTD) (n = 7; composed of dermatomyositis (n = 5), cutaneous lupus erythematosus (n = 1), and systemic sclerosis (n = 1)), panniculitis (n = 4), immunobullous (n = 1), and other (n = 29). Cutaneous features either occurred at time of MDS diagnosis in 25.3%, preceding the diagnosis in 34.7% (range 0.5–216 months), or after diagnosis in 40.0% (range 1–132 months). Prognosis was poor (40.2% death) with 34.1% progressing to acute myeloid leukaemia (AML). 50% of those with MDS who progressed to AML had neutrophilic dermatoses (p = 0.21). Myelodysplastic syndrome was fatal in 39.2% of neutrophilic dermatoses (median time from onset of cutaneous manifestation: 12 months), 50% of vasculitis (7.5 months), 62.5% of granulomatous (15.5 months) and 14.3% of CTD (7 months). Recognition of patterns of cutaneous features in MDS will improve early diagnosis and risk stratification according to subtype and associated prognosis.
Reverse‐phase high‐performance liquid chromatography methodology for film‐forming mafenide spray: Compatibility, assay, and in‐vitro release evaluation using Franz vertical diffusion cell apparatus
Authors: Mahajan Rupali , Chandragiri Sai Teja , Borse Vivek , Samanthula Gananadhamu , Asthana Amit 
Published: February 2024

AbstractThis paper described a short and precise reverse‐phase high‐performance liquid chromatography (HPLC) method for quantifying mafenide in a film‐forming spray and preliminary in‐vitro release study. Following the International Council for Harmonization guidelines Q2 (R1), the method was validated. The chromatographic separation was achieved using a 10 mM potassium dihydrogen phosphate solution (mobile phase A) mixed with HPLC‐grade methanol (mobile phase B) in an 85:15 v/v ratio. Inert Sustain C8 (4.6 × 250 mm), 5 μm column was selected as the stationary phase. The flow rate was set as 0.8 mL/min, and detection was carried out at a wavelength of 222 nm. The developed HPLC method showed an accuracy between 98% and 102%. The primary diffusion study of film‐forming spray was performed using the Franz vertical diffusion cell apparatus. It was observed that an average of 26.94% of drug releases at 24 h. This indicates the drug has a slower release rate and shows local pharmacological action. The Weibull dissolution model was more fitting with regression square 0.9953. Furthermore, the drug excipient compatibility study revealed no interactions as the only drug peak was found in the chromatographic method, indicating that the chosen excipients were appropriate for a stable formulation.