bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel evaluation of clinical outcomes of focal therapy with high-intensity focused ultrasound for the patients with localized prostate cancer using win ratio analysis: A propensity score matched comparison of robot-assisted radical prostatectomy
Authors: Teramoto Asuka , Sakamaki Kentaro , Shoji Sunao , Uemura Kohei 
Published: January 2024

Abstract
Background
The objective of the present study was to compare the comprehensive clinical outcomes of focal therapy (FT) and robot-assisted radical prostatectomy (RARP) in patients with localized prostate cancer (PC) using a win ratio analysis.
Methods
Ninety patients who were treated with FT with high-intensity focused ultrasound and 254 patients who were treated with RARP for localized PC were evaluated. After propensity score matching, a win ratio analysis, in which the composite endpoints of failure-free survival (FFS) and the urinary domain of the Expanded Prostate Cancer Index Composite (EPIC) were analyzed, was used for the comparison of the clinical outcomes of FT and RARP for localized PC.
Results
Seventy-two patients were included in each group after propensity score matching. FFS was not significantly different between the groups (p = 0.5044) after 36 months of follow-up. In contrast, the score of the urinary domain of the EPIC in the FT group was significantly better than that in the RARP group (p < 0.0001). The win ratio of FT per RARP was 3.39 (p < 0.0001; 95% confidence interval: 2.21–5.20), suggesting a higher comprehensive outcome in the FT group than in the RARP group.
Conclusions
The win ratio analysis showed the superiority of comprehensive outcomes of FT to RARP for selected patients with localized PC during short-term follow-up in single institution. Although further randomized trial with long-term follow-up would be needed for the evaluation, the win ratio would be useful to analyze the efficacy of FT according to patient preferences comprehensively.
Under ARMOUR - Donning and doffing of Personal Protective Equipment for simulated CPR of COVID-19 patients
Authors: Kraus Susan , Macherey Romana , Rimkus Lukas , Tschudin-Sutter Sarah , Marsch Stephan , Sellmann Timur 
Published: January 2024

Abstract
Background
Personal protective equipment (PPE) protects healthcare workers and patients. Data on guideline compliance on how to dress (donning) or remove (doffing) PPE and the effect of monitoring (buddying) are limited. This study assesses the quality of donning, doffing, and buddying of PPE in a simulated medical emergency.
Method
Physicians handling a simulated cardiac arrest of a COVID-19 patient. Adjacent to the victim, PPE (FFP2 masks, gowns, caps, protective eyewear, gloves) was available. Data analysis was performed on video recordings. The primary outcome was the number and timing of participants being appropriately protected, defined as both wearing a) all PPE items provided, and b) all PPE items correctly at the time of first patient contact (FPC). Secondary outcomes included compliance with doffing and buddying. Statistical analysis was performed using SPSS (version 28). Mann–Whitney test, Chi-square test, and linear regression analysis were performed as appropriate.
Results
At first patient contact 91/437 (21%) were correctly protected while 306/437 (70%) were partially incorrectly protected. One or more PPE items were missing in 62/437 (15%). Overall donning time was 63 (52–74) seconds, the time interval between donning start and FPC was 66 (55–78) sec. Time to FPC was longer in correctly than in incorrectly protected participants (77 [66–87] vs 64 [54–75] sec; P < 0.0001) and decreased by 7 ± 2 seconds per PPE item omitted (P = 0.002). Correct doffing was observed in 192/345 (56%), buddying in 120 participants (27%).
Conclusions
Our findings imply a need for education in correct and timely PPE donning and doffing. Donning PPE as intended delayed FPC. This and the influence of buddying needs further investigation (German study register number DRKS00023184).
Solitary Splenic Metastasis from Rectal Cancer; A case report and literature review.
Authors: Albahkali Salha M. 
Published: January 2024

Abstract
Abstract:
Background: Metastasis to the spleen is rarely seen on imaging and has been little reported in the literature, requires for early diagnosis and a surveillance staging protocol to get a guide for management at the onset of metastatic diseases, and it can occur at the advanced stages of the disease or posttreatment follow-up evaluation.
Case Presentation: A 59-year-old Saudi female patient diagnosed with rectal adenocarcinoma with metachronous metastatic hepatic and splenic lesions. Clinical examination of the abdomen was rigid with the development of splenomegaly. post-chemotherapy and laparoscopic-assisted diverting colostomy. She has high (CEA) markers and normal levels of hemoglobin. However, we knew she may relapse based on an advanced stage, thus, the progression of the disease was reported in the form of hepatic (82%) and splenic (46%) lesions.
Conclusion:
Splenic metastasis is an unusual entity, an incidental finding of radiological examination, requiring further investigation to confirm the malignant character. The standard method in therapeutic strategies for splenic metastasis has not been constituted. Known treatment options include splenectomy, chemotherapy, and radiotherapy.
Mechanisms of Atractylodes macrocephala Koidz. on therapy to diarrheal disease: A systematical review and meta-analysis of preclinical evidence
Authors: Ran Pancen , Jiang Fengxian , Lai Jingjiang , Shu Yang , Zhao Jing , Zhang Zhizhao , Hu Fangyan , Wang Juqiong , Wei Jian , Fu Guobin 
Published: January 2024

Abstract
Background
Atractylodes macrocephala Koidz. (AMK) is a traditional Chinese medicine used for the treatment of various diseases. Atractylenolide and polysaccharide from Atractylodes macrocephala Koidz. (PAMK) are the representative bioactive components in AMK. There have been many in vivo studies on AMK for the treatment of diarrhea, the most common gastrointestinal disorder worldwide and the high mortality rate. The aim of this study is to assess the effectiveness of AMK in treating diarrhea using preclinical evidence and meta-analysis. Additionally, the primary mechanisms by which AMK acts against diarrhea are summarized.
Methods
We systematically searched PubMed, WOS, Embase, Cochrane Library, WanFang, CNKI, Cqvip and CBM databases and other databases from January 1, 2000, to March 10, 2023, to evaluate the animal experiments of AMK for the treatment of diarrhea. Finally, 23 animal experiments were included. Thirteen outcome measures, including overall condition(body weight, diarrhea score, disease activity index), immune-related indicators (colon length, spleen index, histopathological score, SIgA), pro-inflammatory factors(IL-1β, IL-6, IL-17,TNF-α), anti-inflammatory factors(IL-10) and MPO were obtained by using Review Manager 5.4 software for meta-analysis.
Results
Except for the indicator of spleen index, which was not significant difference, it was significantly decreased in the indicator of diarrhea score, disease activity index, histopathological score and significantly elevated in the indicator of body weight, colon length. It showed that AMK could improve immune function in diarrhea. Meanwhile AMK significantly down-regulated pro-inflammatory factors, IL-1β, IL-6, IL-17, TNF-α and MPO, up-regulated anti-inflammatory factors IL-10, indicating that AMK may have anti-inflammation and anti-oxidation effects.
Conclusion
AMK exhibits protective effects against diarrhea through immunoregulation, anti-inflammation, anti-oxidation, and regulation of intestinal flora. These findings provide preclinical evidence supporting the application of AMK in diarrhea treatment.
Bi-Directional Cannulation of the PTA for Lower Extremity Ischemia during pVA-ECMO：A Case Report
Authors: Liu Chuang , Li Xingxing , Fu Guowei , Li Jun , Sun Qianqian , Zhao Junjie 
Published: January 2024

Abstract
Objective:
Currently, there is no effective solution for patients undergoing peripheral veno-arterial extracorporeal membrane oxygenation(pVA ECMO) who continue to experience limb ischemia despite the placement of a distal perfusion cannula through the superficial femoral artery.This case study presents the use of bi-directional perfusion of the posterior tibial artery as a remedial measure against limb ischemia following pVA ECMO. The patient was successfully weaned from pVA ECMO after 8 days and transferred to the rehabilitation center 16 days later. In this case, the patient's right foot was saved by bi-directional perfusion of the posterior tibial artery, while the surgical repair during extubation preserved the artery. This approach is unique worldwide.
Prediction of the Soluble Solid Content of Citrus Based on the Fractional-Order Derivative and Optimal Band Combination Algorithm
Authors: Dou Shiqing , Deng Yuanxiang , Zhang Wenjie , Yan Jichi , Mei Zhengmin , Li Minglan 
Published: January 2024

Abstract
The soluble solid content (SSC) is a primary characteristic index for evaluating the internal quality of citrus fruits. The development of rapid and nondestructive SSC detection techniques can help address the current issues of postharvest quality grading in China's citrus industry. In this study, Three varieties of citrus were used as experimental materials. After obtaining the reflection spectra and SSCs,SNV-FOD (Standard Normal Variate - Fractional-Order Derivative) was used to process the spectra, and the optimal band combination algorithm (OBC) was introduced to select SSC-sensitive bands. Then, the obtained optimal dual-band combination was input into eight regression models for comparison, and the best-performing models stacked ensemble models was selected. Finally, the H-ELR (HyperOpt-optimized Ensemble Learning Regression) model, optimized using a Bayesian function, was applied for the effective prediction of citrus SSC. The results shows that (1) The SNV-FOD preprocessing method proposed in this paper improved the correlation coefficient with the SSC by 0.29 compared to that of the original spectrum; (2) The optimal dual-band combination (969 and 1069 nm) constructed by integrating the differential index (DI) and 1.2-order derivative yielded the most accurate results (RPD = 2.13); and (3) The H-ELR model, based on HyperOpt optimization, achieved good predictive performance (RPD = 2.46). This research contributes to the development of practical SSC prediction instruments with excellent universality and ease of application.
Predictors of Extrapyramidal Side Effects among Patients Taking Antipsychotic Medication at Mekelle Psychiatry Units, Northern Ethiopia, 2023: Unmatched Case-Control Study
Authors: Gebru Welu Abadi , Asfaw Gebregziabher Kidanemariam , Berhe Knife Tesfay , Begashaw Tesfaye Derbie , Reta Hiwot Gebrewahid , Gebresilassie Hagos Tsegabrhan 
Published: January 2024

Abstract
Background
Schizophrenia is one of the most disruptive of neuropsychiatric disorders, affecting around 1% of the world's population. Antipsychotic medications have been the backbone of schizophrenia treatment for the past 50 years. Extrapyramidal side effects of antipsychotic medication are a major problem which is associated with various factors. However, there is a dearth of evidence about the predicting factors for extrapyramidal side effects.
Objective
To determine the predictors of extrapyramidal side effects among patients taking antipsychotic medication at Mekelle Psychiatry units, Northern Ethiopia, 2023
Methodology:
A Case-control study design was employed with a total of 201 study subjects (67cases and 134 controls). A systematic random sampling technique was employed to select the required study subjects. Extrapyramidal Side Effects were measured by the Simpson-Angus Scale, Abnormal Involuntary Movement Scale (AIMS), and the Barnes Akathisia Rating Scale (BARS) scale. The data were analyzed using Statistical Package for Social Sciences (SPSS) version 22. Bivariate and multiple logistic regression analyses were performed to determine between the independent and dependent variables. The significant independent predictor was declared at a 95% confidence interval and P-value of less than 0.05.
Result
Among the study subjects the modifiable factors significantly associated with EPS were; being female(AOR = 0.140, 95% CI: .0.042–0.465, p = 0.001),being single (AOR = 3.084, 95% CI: 0.569–16.727, p = 0.006), perceived stigma (AOR = 0.165, 95% CI: 0.038–0.708, p = 0.015), having mental illness history (AOR = 6.316, 95% CI: 2.026–19.692), p = 0.001), combination first generation antipsychotic drugs(AOR = 0.095 ,95% CI: 0.010–0.877, p = 0.038), Kchat chewing practice/ behavior (AOR = 4.033, 95% CI: 1.120-14.531, p = .033) and history of alcohol use and currently drink alcohol (AOR = 6.213, 95% CI: 1.375–28.079, p = 0.018).
Conclusion and recommendation:
Our study revealed, being female, single, stigma, combination first-generation antipsychotic drug, having mental illness history, Kchat chewing practice/ behavior and Alcohol intake in the last 3 months were significant factors of Extrapyramidal Side Effects. Psychiatric professionals should be assessing the predictors of Extrapyramidal Side Effects especially, combination of first-generation antipsychotic drugs, substance use with antipsychotic drugs and management comorbid diagnosis routinely is strongly recommended.
Outcomes of maze procedure and cardiac surgery in atrial functional mitral regurgitation: a retrospective study
Authors: Song Kyungsub , Jang Woo Sung , Kim Yun Seok , Yoo Jonghoon 
Published: January 2024

Abstract
Background
Atrial functional mitral regurgitation (AFMR) is a newly discovered condition associated with longstanding atrial fibrillation. This retrospective study aimed to analyze the outcomes of the maze procedure and mitral regurgitation (MR) surgery in AFMR and atrial fibrillation in comparison with those in degenerative MR (DMR).
Methods
Patients who underwent mitral valve repair/replacement with a maze procedure at a hospital (July 2012–August 2021) were included. We excluded patients aged below 18 years undergoing concomitant coronary artery bypass grafting or atrial septal defect repair and those with MR etiology other than ARMR or DMR.
Results
We included 35 patients with AFMR and 50 patients with DMR. Patient characteristics and postoperative outcomes were not significantly different between the 2 groups. Long-term outcomes revealed no significant differences in the ratio of cardiac mortality, stroke, or hospital readmission. However, a junctional rhythm state on electrocardiography after the maze procedure (p < 0.001) and permanent pacemaker insertion for sick sinus syndrome (SSS) (p = 0.03) were significantly more common in the AFMR group. On postoperative transthoracic echocardiography (TTE), the pulmonary artery systolic pressure was significantly less decreased in the AFMR group than in the DMR group compared with that on preoperative TTE (p = 0.04), attributed to the AFMR group’s significantly higher tricuspid regurgitation (TR) recurrence after tricuspid annuloplasty (TAP) (p = 0.01).
Conclusions
AFMR showed excellent mitral valve surgery outcomes, similar to DMR, but had a significantly higher risk of pacemaker insertion for SSS and TR recurrence after TAP.
Reflexive symmetric differentials and quotients of bounded symmetric domains
Authors: Patel Aryaman 
Published: January 2024

Abstract

For each classical irreducible bounded symmetric domain $\mathcal{D}$, Klingler has computed the minimum number $m_{\mathcal{D}}$ such that any smooth projective quotient $X=\mathcal{D}/\Gamma$, for $\Gamma\in\textrm{Aut}^0(\mathcal{D})$, satisfies $H^0(X,\mathrm{Sym}^i\Omega^1_X)=0$ for $0
A new blow-up criterion for a $p$-Laplacian type pseudo-parabolic equation with singular potential and logarithmic nonlinearity
Authors: Yang Hui 
Published: January 2024

Abstract
In this paper, a p-Laplacian type pseudo-parabolic equation with singular potential and logarithmic nonlinearity is considered and finite time blow-up of solutions is proved with initial data at arbitrarily high initial energy level. A new criterion for the solutions to blow up in finite time is established by using Gagliardo-Nirenberg's interpolation inequality and inverse Sobolev inequality. It is worthy to point out that the lifespan of the weak solutions is estimated from both above and below. From methods to results, we partially extend some results obtained in recent literatures.
AMS Mathematics Subject Classification 2010: 35K55, 35B44.
High-throughput Light-induced Immunoassay under One-minute Antibody-coating with Energy Saving Nanoparticle-imprinted Substrate
Authors: Iida Takuya , Kanoda Masatoshi , Hayashi Kota , Takagi Yumiko , Tamura Mamoru , Tokonami Shiho 
Published: January 2024

Abstract
The efficient detection of harmful viruses and protein biomarkers is critical for public health. However, the sensitivity of conventional antigen test kits is relatively low for early diagnosis, and laboratory immunoassays require complex pretreatment processes overnight. If target nanomaterials could be remotely guided to the detection site, simpler and faster methods would be developed. Here, we reveal that nanoparticles modified with spike proteins of SARS-CoV-2 can be selectively detected with 1/100 of virus concentration in saliva via a two-step optical condensation using our nanoparticle-imprinted plasmonic substrate (NPI-PS), where anti-spike-protein antibody was coated on NPI-PS over submillimeter area within one minute. NPI-PS exhibits high-performance optical condensation with high photothermal properties even under noninvasive milliwatt-class laser irradiation, enabling quantitative measurements of nanoparticles ranging from 106–1010 particles/mL within a few minutes. These findings support an innovative strategy to mitigate pandemic threats and various diseases through the high-throughput detection of various protein biomarkers.
Evaluation of analgesic effects of doxepin cream in patients with knee osteoarthritis
Authors: Mazhari Hossein , Majmasanayea Mahnam , Eshraghi Azadeh , Eslami Neda 
Published: January 2024

Abstract
Background and purpose
Osteoarthritis is the most common type of arthritis, and knee osteoarthritis is one of the most important types, which causes symptoms such as pain and stiffness of the knee, followed by a weakening of physical performance and a decrease in quality of life. Among the complementary treatments that are of interest are new and optimal drugs that can reduce the pain and discomfort of patients with fewer side effects. We aim to investigate the effect of doxepin cream in reducing pain in patients with knee osteoarthritis.
Methods
In this double-blind clinical trial, 60 patients with knee osteoarthritis were selected and randomly divided into 3 groups of 20 people. The first group used placebo cream 2 times a day, the second group used 5% doxepin cream 2 times a day, and the third group used diclofenac 1% topical gel 2 times a day. All three groups used 250–500 mg naproxen tablets orally daily. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) questionnaires were checked at the beginning of the study and six weeks after the start of treatment. Improvement of physical function and reduction of pain is considered as a response to treatment.
Results
This study showed that after the doxepin intervention, in second group there was a significant difference in knee pain (P < 0.005), dryness during the day (P < 0.05), morning dryness (P < 0.05), and physical performance (P < 0.05) between the groups. In the two groups receiving doxepin cream and diclofenac gel, there was a significant reduction in symptoms (pain and stiffness of the knee) and an improvement in physical performance.
Conclusion
The topical form of doxepin, which was prepared as a cream, reduced knee pain, morning dryness, and dryness during the day and improved the physical performance of patients with primary knee osteoarthritis. It seems that the reduction of patient symptoms is due to the inhibitory effects on NMDA(N-methyl-D-aspartate) receptors, as well as the inhibitory effects on noradrenaline and 5-hydroxytryptamine reabsorption, as well as the inhibition of sodium voltage channels.
Assessing the Preservation Effectiveness: A Comparative Analysis of Plasma Activated Water and Various Preservatives on Capsicum annuum L. (Jalapeño and Pusa Jwala)
Authors: Rathore Vikas 
Published: January 2024

Abstract
The study investigated the efficacy of plasma-activated water (PAW) in preserving green chillies (jalapeño and pusa jwala) and compared it with various household cleaners' solutions. PAW was prepared using a pencil plasma jet with air as the plasma forming gas. The results of visual analysis revealed that PAW-treated chillies maintained a better appearance even after 21 days, exhibiting significantly lower spoilage compared to control and cleaners. Physicochemical properties of PAW, including acidity and oxidizing potential, increased with plasma treatment time, influencing reactive species concentration. PAW demonstrated antimicrobial properties, effectively reducing microbial growth and spoilage on chillies over the storage period.
Physical attributes, such as weight loss and firmness, were evaluated, with PAW-treated chillies exhibiting lower weight loss and higher firmness, indicating better membrane integrity and moisture retention. Microbial resistance was notably higher in PAW-treated chillies compared to control and cleaners. CIELAB color analysis revealed that PAW-treated chillies retained greenness and color freshness, outperforming control and cleaners. Sensory evaluation, including visual inspection, smell, taste, and touch, consistently favored PAW-treated chillies, emphasizing their superior shelf-life extension.
Biochemical analysis showed that PAW-treated chillies maintained or enhanced nutritional attributes such as soluble sugar, protein, and ascorbic acid concentrations. Phenol concentration (antioxidant activity) remained stable across treatments. Overall, the study underscores the positive impact of PAW treatment on preserving the membrane integrity, antimicrobial resistance, sensory quality, and nutritional attributes of green chillies, making it an alternative for extending their shelf life.