bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter to Editor
Authors: Intan Suhana Munira Mat Azmi  
Published: January 2024

As a researcher and public health lecturer, the misinformation on vaping is perturbing. The prime belief of the society that vape is a safe alternative to smoking is completely mistaken. The fact that vaping is not less harmless than smoking needs to be widely disseminated. Vape does contain harmful chemicals i.e. nicotine, propylene glycol, glycerol and few others that aren’t listed on the pack. These chemicals when inhale can lead to serious respiratory problems including lung injuries (EVALI), pneumonia, pneumothorax and acute respiratory distress syndrome (ARDS). Apart from that, nicotine can cause addiction, poisoning and prolong use of nicotine can lead to increased risk of heart disease, suppress immune system, DNA mutation and brain development retardation. The health effects of vaping not only affecting those who vape but also other people who are exposed as second-hand vapers.
KEWENANGAN PENGELOLAAN HARTA KEKAYAAN ORANG DIBAWAH PENGAMPUAN OLEH BALAI HARTA PENINGGALAN SURABAYA
Authors: Wisuda Selvia 
Published: January 2024

Balai Harta Warisan existed since the Dutch era to Indonesia around 1596. In order to find out the position of Balai Harta Warisan which has the task of managing the assets of people under supervision when it is related to positive law in Indonesia. With empirical juridical research, there will be primary and secondary data that will be processed. The results showed that the position of Balai Harta Peningalan is still recognized as a state institution and is still valid. The function of Balai Harta Pengrelican is to resolve issues of guardianship, custody, absence and inheritance that have no authority, etc. in accordance with article 3 of the Decree of the Minister of Justice and has the task of representing and taking care of the interests of people who cannot carry out their own interests. As a supervisor to protect the interests of Curandus and protect him from the actions of the custodians who may cause losses to his property while still within the time of custody. Carry out bookkeeping and registration of wills in accordance with the law and carry out the settlement of bankruptcy problems in accordance with the law. At present Balai Harta Warisan in Indonesia has a working area covering Balai Harta Warisan Jakarta, Surabaya, Semarang, Medan and Makassar
Keywords: Relic Hall, Forgiveness, Wealth Property
أثر القيادة الجديرة بالثقة على الانطمار الوظيفي
Authors: الصويعي د. هند خليفة , عبدالسيد د. سهام إبراهيم 
Published: January 2024

هدفت هذه الدراسة إلى التعرف على مستوى ممارسة أبعاد القيادة الجديرة بالثقة من وجهة نظر الموظفين في إدارة الموارد البشرية بشركة سرت, وكذلك معرفة مستوى الانطمار الوظيفي لدى الموظفين, كما استهدفت الدراسة أيضاً معرفة أثر القيادة الجديرة بالثقة على الانطمار الوظيفي لدى الموظفين في إدارة الموارد البشرية بشركة سرت. ولتحقيق أهداف الدراسة تم تطوير استبانة اعتمادا على بعض الدراسات السابقة، تضمنت (32) فقرة لجمع البيانات الأولية بالتطبيق علي عينة عشوائية بسيطة من الموظفين مكونة من (155) مفردة. وفي ضوء ذلك تم تحليل البيانات باستخدام الحزمة الإحصائية (SPSS)، وقد توصلت الدراسة إلى مجموعة من النتائج، أهمها أن المستوى العام للقيادة الجديرة بالثقة كان مرتفعاً، و كشفت الدراسة أن المستوى العام للانطمار الوظيفي قد جاء أيضا مرتفعا، كما أوضحت نتائج الدراسة أيضا أن هناك أثرا ذا دلالة إحصائية للقيادة الجديرة بالثقة مجتمعة على الانطمار الوظيفي، ووجود أثر ذي دلالة إحصائية لبعُد المنظور الأخلاقي علي الانطمار الوظيفي، وعدم وجود أثر ذي دلالة إحصائية للأبعاد (التشغيل المتوازن، شفافية العلاقات، الوعي الذاتي). وأخيرا قدمت الدراسة مجموعة من التوصيات التي قد تُسهم في تعزيز ممارسة القيادة الجديرة بالثقة، وترفع من مستوى الانطمار الوظيفي بشركة سرت لإنتاج وتصنيع النفط والغاز بمدينة البريقة.
عـلاقـة الحوكمة الرشيدة بالالتزام التنظيمي
Authors: العبار د. بشير محمد 
Published: January 2024

هدفت الدراسة إلى التعرف على مستوى تطبيق الحكومة الرشيدة بمعاييرها (الشفافية، العدالة، المشاركة، المساءلة، سيادة القانون، والرؤية الإستراتيجية) وعلاقتها بالالتزام التنظيمي بديوان بلدية بنغازي، ولتحقيق أهداف الدراسة، اتبع الباحث المنهج الوصفي التحليلي، واستخدم استمارة الاستبيان كأداة رئيسية في تجميع البيانات. وتكون مجتمع الدراسة من جميع مديري الإدارات العليا والوسطى والتنفيذية، بلغ عددهم (65 مديرا). وقد تم استخدام أسلوب المسح الشامل، وكذلك برنامج الحزم الإحصائية (SPSS) في تحليل بيانات الدراسة. وتوصلت الدراسة إلى العديد من النتائج أهمها، أن مستوى تطبيق الحوكمة الرشيدة ودرجة الالتزام التنظيمي كانا متوسطين، ووجود علاقة موجبة قوية بين تطبيق الحوكمة الرشيدة بمعاييرها مجتمعة والالتزام التنظيمي، وكذلك وجود علاقة موجبة قوية بين تطبيق معاييرالحوكمة الرشيدة (الشفافية، العدالة، والمشاركة) والالتزام التنظيمي، كما توصلت الدراسة أيضا إلى وجود علاقة موجبة ضعيفة بين تطبيق معيارالرؤية الإستراتيجية والالتزام التنظيمي. وبناء على نتائج الدراسة تم تقديم مجموعة من التوصيات التي يؤمل أن تُسهم بتعزيز مستوى تطبيق معايير الحوكمة الرشيدة، وفي تحسين درجة الالتزام التنظيمي بديوان بلدية بنغازي.
Pianistin kysymys soiton hallinnasta
Authors: Kivistö Tuomas 
Published: January 2024

The demonstration of proficiency for my doctoral degree consisted of five concerts of piano music by Sergei Rachmaninoff and a thesis focusing on questions of control in playing Rachmaninoff’s Moment musical Op. 16 No. 2 E-flat minor. The thesis suggests a way in which Rachmaninoff may have finger pedalled his piano compositions. It also includes exercises for pianists’ practical use.
Kajian Konseptual E-Modul Berbasis Discovery Learning untuk Meningkatkan Hasil Belajar
Authors: Agapau Julianti Dian Lestari , Ningsih Kurnia , Titin  
Published: January 2024

E-modules based on discovery learning are electronic teaching materials containing videos, images and audio which are arranged systematically and include the stages or syntax of the discovery learning model, namely stimulus, problem identification, data processing, proof and conclusions. The concepts obtained in this discovery learning-based e-module are not shown final form, but rather students recognize and prove existing concepts so that they gain meaningful knowledge and long-lasting memories. Therefore, this teaching material requires student activity because discovery learning-based e-modules encourage students to learn independently. The teacher only acts as a facilitator or accompanies students. This research aims to determine the effectiveness of discovery learning-based e-modules in improving student learning outcomes. The research method used is literature study, where the data obtained is recorded, analyzed and concluded. The results of the study show that e-modules based on discovery learning are able to improve student learning outcomes.
Aproximación diagnóstica a las Cefaleas después de los 65 años
Authors: Cornejo A Luis Manuel 
Published: January 2024

Con el objetivo de facilitar el diagnóstico diferencial de la queja de cefalea después de los 65 años de edad, se llevó a cabo una revisión de la literatura con respecto a las cefaleas primarias y secundarias de acuerdo a la Clasificación de la Sociedad Internacional de Cefaleas, seleccionándose las variedades más frecuentes en las personas mayores, describiéndose su condición aguda o crónica, su frecuencia, características y particularidades, a manera de facilitar un diagnóstico presuntivo que oriente una intervención específica. Las cefaleas primarias más frecuentes en el adulto mayor son la cefalea tensional y la migraña. Entre las cefaleas secundarias más frecuentes se encuentran la cefalea cervicogénica, la cefalea por abuso de analgésicos, dolor craneal y las diferentes causas de cefaleas metabólicas. Se mencionan los estudios básicos y paraclínicos, así como los criterios para estudio por neuroimagen y las señales de alerta para cefaleas secundarias.
Evaluation of Fusobacterium nucleatum in Amniotic Fluid of Women with Preterm Labour
Authors: Nwaokorie Francisca , Okunade Kehinde S. , Edet Uwem , Obisanya Olukayode , Ekun Ayodele 
Published: January 2024

Objective: The effect of Fusobacterium nucleatum, an oral commensal, on pregnancy outcomes is of global concern. This study screened for F. nucleatum and the fadA gene in amniotic fluid obtained from women presenting with preterm labour.
Methods: This is a cross-sectional pilot study. Amniotic fluid was collected from women with preterm labour at Lagos University Teaching Hospital and analysed using conventional polymerase chain reaction (PCR). I6SrRNA species-specific primers were used to assess the presence of F. nucleatum species and fadA genes for virulence potentials. Questionnaire-based data obtained was analysed using SPSS version 20.0. and amplicon analysis was measured on base pairs.
Results: Fourty participants had preterm deliveries between April and August 2018. Of these 34 (85%) were enrolled, out of which 25 amniotic fluid samples (AF) were collected. The mean age of the participants was 30.5 years. Among them, 10 (29.4%) were primigravida, and 24 (70.6%) were multigravida. Six (1.8%) of the women had a history of gestational diabetes, and four (1.2%) had hypertension. Only 4 (1.2%) were aware that bacteria could cause preterm labour. 11 (32%) visited the dentist during the period of their pregnancy. There was no amplification of 16SrRNA or the fadA genes in the tested samples.
Conclusions: This study showed that preterm delivery was more common in multigravida pregnant women aged 31-35 years. Although some of the samples were cloudy and purulent, Fusobacterium nucleatum species-specific and virulent fadA genes were not detected in amniotic fluid obtained from the population of women with preterm labour studied.
Fasting Versus a Heart-Healthy Diet Before Cardiac Catheterization: A Randomized Controlled Trial
Authors: Woods Carri , Wood Michelle , Boylan Angela , Flanagan Mindy E. , Powers Jan 
Published: January 2024

Background
Patients undergoing cardiac catheterization are ordered to take nothing by mouth after midnight before their procedure with no evidence to support this practice.

Objective
To identify best practice for fasting requirements before cardiac catheterization through comparative evaluation in a prospective randomized controlled study.

Methods
The study included a convenience sample of 197 patients undergoing elective cardiac catheterization in a progressive inpatient cardiac unit at a regional heart institute in the midwestern United States. The patients were randomized into 2 groups. Patients in the heart-healthy diet group could eat a specified diet with low-acid options until the scheduled procedure. Patients in the fasting group were restricted to nothing by mouth after midnight except for sips of water with medications until the scheduled procedure. Outcome measures included patient-reported satisfaction and complications.

Results
Compared with patients in the fasting group, those in the heart-healthy diet group had significantly more satisfaction with the preprocedural diet. Patients in the heart-healthy diet group had less thirst and hunger before and after the procedure. No patients experienced pneumonia, aspiration, intubation, or hypoglycemia after the procedure. Fatigue, glucose level, gastrointestinal issues, and loading dose of antiplatelet medication did not differ between the groups.

Conclusions
Allowing patients to eat before elective cardiac catheterization posed no safety risk and benefited patient satisfaction and overall care. The results of this study may help identify best practice for allowing patients to eat before elective procedures using conscious sedation.
Fluid Resuscitation and Sepsis Management in Patients with Chronic Kidney Disease or End-Stage Renal Disease: Scoping Review
Authors: Haley Matt , Foroutan Nasim Khosravi , Gronquist Juliann M. , Reddy Raju , Wusirika Raghav , Khan Akram 
Published: January 2024

Managing sepsis and fluid resuscitation in patients with chronic kidney disease or end-stage renal disease is challenging for health care providers. Nurses are essential for early identification and treatment of these patients. Nurse education on assessing perfusion and implementing 3-hour bundled care can improve mortality rates in patients with sepsis. In this scoping review, initial screening identified 1176 articles published from 2015 through 2023 in the National Library of Medicine database; 29 articles were included in the literature summary and evidence synthesis. A systematic review meta-analysis was not possible because of data heterogeneity.
The review revealed that most patients with chronic kidney disease or end-stage renal disease received more conservative resuscitation than did the general population, most likely because of concerns about volume overload. However, patients with chronic kidney disease or end-stage renal disease could tolerate the standard initial fluid resuscitation bolus of 30 mL/kg for sepsis. Outcomes in patients with chronic kidney disease or end-stage renal disease were similar to outcomes in patients without those conditions, whether they received standard or conservative fluid resuscitation. Patients who received the standard (higher) fluid resuscitation volume did not have increased rates of complications such as longer duration of mechanical ventilation, increased mortality, or prolonged length of stay. Using fluid responsiveness to guide resuscitation was associated with improved outcomes.
The standard initial fluid resuscitation bolus of 30 mL/kg may be safe for patients with chronic kidney disease or end-stage renal disease and sepsis. Fluid responsiveness could be a valuable resuscitation criterion, promoting better decision-making by multidisciplinary teams. Further research is required.
Use of the 3 Wishes Project to Help Individualize End-of-Life Care in a Medical Intensive Care Unit
Authors: Harrison Brittany H. , Hundt Elizabeth , Wiencek Clareen 
Published: January 2024

Background
Multiple organizations recommend that individualized end-of-life (EOL) care should be standard practice. However, a standardized approach does not exist because EOL care should be individually tailored. The 3 Wishes Project is an EOL intervention that provides direction for individualized care with 3 goals: dignify death, celebrate the patient’s life, and support family members and the intensive care unit clinicians caring for the patient. Patients and families are given the opportunity to choose 3 wishes during the dying process.

Objective
To ascertain if the implementation of the 3 Wishes Project allowed the medical team to provide individualized EOL care.

Methods
The Iowa Model was used for this evidence-based project. The project was implemented in the medical intensive care unit at an academic medical center. Outcomes were evaluated by the collection and analysis of qualitative and quantitative data.

Results
From the 57 patients who died during the 2-month implementation period, 32 wish forms were collected; 31 patients participated and 1 declined. Overall participation among patients was 56%. The top 5 wishes were cloth hearts, blankets, heartbeat printouts, fingerprints and handprints, and music. The total cost was $992, and the average cost per wish was $6.98. Eighty-five percent (33 of 39) of the respondents to the medical team survey indicated that they either agreed or strongly agreed that the project allowed the medical team to consistently provide individualized EOL care.

Conclusions
The survey data support the 3 Wishes Project as a method that allowed the medical team to individualize EOL care and as a valuable tool for incorporation at the bedside.
Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines
Authors: Aung Aereas , Irvine Darrell J 
Published: January 2024

Abstract
Primary immune responses following vaccination are initiated in draining lymph nodes, where naive T and B cells encounter Ag and undergo coordinated steps of activation. For humoral immunity, the amount of Ag present over time, its localization to follicles and follicular dendritic cells, and the Ag’s structural state all play important roles in determining the subsequent immune response. Recent studies have shown that multiple elements of vaccine design can impact Ag availability in lymphoid tissues, including the choice of adjuvant, physical form of the immunogen, and dosing kinetics. These vaccine design elements affect the transport of Ag to lymph nodes, Ag’s localization in the tissue, the duration of Ag availability, and the structural integrity of the Ag. In this review, we discuss these findings and their implications for engineering more effective vaccines, particularly for difficult to neutralize pathogens.
Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa
Authors: GADJI Macoura , Gueye Youssou Bamar , Motto David , Diop Saliou 
Published: January 2024

Introduction : According to WHO, regular, voluntary, unpaid blood donors are the safest group of donors, as they have the lowest prevalence of blood transmitted infections. However, family/replacement blood donors is widely used in sub Saharan Africa and this practice was exacerbated during the COVID 19 pandemic. This study aimed to compare the seroprevalence of infectious markers in family replacement blood donors and voluntary non-remunerated blood donors during the COVID 19 pandemic in a country of sub Saharan Africa.
Materials and Methods
Blood donors received at the National Centre of Blood Transfusion (NBTC) of Dakar from August 1st to October 31th 2021, were included in this study. All donors completed a pre-donation questionnaire. Donors identity, epidemiological parameters, reasons for donation and laboratory results were collected in the Inlog® software of the NBTC. The serological tests for HBV, HIV and HCV were performed with chemiluminescence technology. The Rapid Plasma Reagent test was used to find out treponemal antibodies. The determination of ABO and Rh blood groups was performed using monoclonal antisera following classical hemagglutination test on a plate.
Results
A total of 5002 donors were collected during this COVID-19 pandemic period. Blood family/replacement donors represented 54.0% and new voluntary donors represented 52.6%. Comparison of HIV, HCV and syphilis markers seroprevalence showed no statistically significant difference between new voluntary donors and new family replacement donors (p>0.05). However, for HBV the seroprevalence was significantly higher in new family replacement donors (p=0,002).
Conclusion
The proper supply of blood was impacted by the COVID-19 pandemic meanwhile replacement donations had contributed to limiting the damage observed with blood shortages. However, the significant differences noted on the seroprevalences of transfusion-transmissible infections between voluntary non-paid donors and family/replacement donors strengthens WHO recommendations for the selection of volunteer non-paid donors to lower transfusion-transmissible HBV in sub Saharan Africa.
CAR-T CELL THERAPY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Authors: Testa Ugo , Sica Simona , Pelosi Elvira , Castelli Germana , Leone Giuseppe 
Published: January 2024

Treatment of refractory and relapsed (R/R) B acute lymphoblastic leukemia (B-ALL) is an unmet medical need in both children and adults. Studies carried out in the last two decades have shown that autologous T cells engineered to express a chimeric antigen receptor (CAR-T) represent an effective technique for treating these patients. Antigens expressed on B-cells, such as CD19, CD20, and CD22, represent targets suitable for treating patients with R/R B-ALL. CD19 CAR-T cells induce a high rate (80-90%) of complete remissions in both pediatric and adult R/R B-ALL patients. However, despite this impressive rate of responses, about half of responding patients relapse within 1-2 years after CAR-T cell therapy. Allo-HSCT after CAR-T cell therapy might consolidate the therapeutic efficacy of CAR-T and increase long-term outcomes; however, not all the studies that have adopted allo-HSCT as a consolidative treatment strategy have shown a benefit deriving from transplantation.
For B-ALL patients who relapse early after allo-HSCT or those with insufficient T-cell numbers for an autologous approach, using T cells from the original stem cell donor offers the opportunity for the successful generation of CAR-T cells and for an effective therapeutic approach.
Finally, recent studies have introduced allogeneic CAR-T cells generated from healthy donors or unmatched, which are opportunely manipulated with gene editing to reduce the risk of immunological incompatibility, with promising therapeutic effects.
Keywords: CAR T; Acute Lymphoid Leukemia; Allogeneic CAR-T; Autologous CAR-T.
Aedes aegypti oviposition in urban communities in the Northern Chihuahuan Desert
Authors: Vera Adam J , Soliz Albert G , de la Mora-Covarrubias Antonio , Watts Douglas M 
Published: January 2024

Background & objectives:

Aedes aegypti (Linnaeus) is the vector of multiple arboviruses, the most important being dengue viruses (DENV) that causes more than 90 million cases per year. The expanded range of Ae.
aegypti into temperate climates has contributed to the increasing risk of DENV to new human populations. As an effort to better understand the ecology of Ae. aegypti in a temperate climate, larval surveillance was conducted to identify oviposition locations of this species from 2016-2018 in two nonincorporated communities located in El Paso, Texas and Ciudad Juarez, Chihuahua, Mexico.

Methods:
This survey was conducted inside and outside private residences examining any possible water holding containers to collect with a dipper, turkey baster, or Pasteur pipette. Larvae and pupae were transported to the laboratory and reared to adults for morphological identification. A total of 601 Ae. aegypti larvae were collected and reared to adults from 24 containers in the Sparks community. In contrast, a total of 68 Ae. aegypti were collected and reared to adults from seven containers in the Anapra community.

Results:
In both locations, the predominant container type that yielded immature mosquitoes were plastic buckets. Although the results were based on a small sample size, the finding provided a preliminary understanding of the oviposition sites of Ae. aegypti in two urban communities in a temperate climate region.

Interpretation & conclusion:
The identification of oviposition sites can be used to develop and implement vector control strategies.