bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event-triggered Optimal Consensus for Discrete-time Nonlinear Multiagent Systems with DoS attacks via Reinforcement Learning Method
Authors: Liao Yujie , Wang Xin , Wang Ziming , Zhang Sen 
Published: January 2024

Abstract
This paper focuses on the event-triggered optimal control problem of discrete-time nonlinear multiagent systems (MASs) via the reinforcement learning method. Distinguished from the existing consensus protocols for discrete-time multiagent systems under the ideal communication scenario, the considered model suffers from input saturation, unknown external disturbance, and denial-of-service (DoS) attacks. According to the approximation capability of the radial basis function neural network(RBF NN), the disturbance network is established to tackle the effect of the unknown disturbance on consensus issues. Subsequently, the composite controller is derived with the reinforcement learning strategy to deal with the DoS attacks, where the update frequency of the actor-critic networks and controllers is determined by the novel event-triggered mechanism. Finally, two simulations are formulated to verify the feasibility of the proposed method.
Scavenger Receptor Genes Polymorphisms Association with Tuberculosis and Latent Tuberculosis Infection in Pakistani population
Authors: Tariq Ezza Binte , Subhan Urooj , Deeba Farah , Ullah Riaz , Tariq Zuha , Liaquat Afrose , Younis Sidra 
Published: January 2024

Abstract
Host genetics is pivotal in deciding disease susceptibility and outcome in individuals infected with Mycobacterium tuberculosis (Mtb). Scavenger receptors are PRRs that play a vital role in facilitating molecular interactions between Mtb and the host. This interaction can potentially be modified by polymorphisms in scavenger receptor genes. The role of scavenger receptors in TB or LTBI pathogenesis has not yet been studied. Therefore, we designed a case-control study to investigate the association of polymorphisms in the CD36 gene at rs1761667 (G>A) and rs3211938 (T>G), and SR-B1 gene at rs4238001 (G>A) with TB and LTBI in the Pakistani population using ARMS-PCR. Fisher's exact chi-square test was used to compare genotypes between study groups. We found that rs4238001 (AA, p=0.00) and rs1761667 (AA, p=0.03) were significantly associated with active TB. Furthermore, rs1761667 (GA, p=0.00) and rs3211938 (GG, p<0.00) were significantly associated with LTBI. Our findings suggest that SR-B1 and CD36 gene polymorphisms may contribute to TB pathogenesis in the Pakistani population. Furthermore, different genotypes of a single SNP can have varying effects on the susceptibility to both TB and LTBI. Further studies on polymorphism-associated gene expression will provide insights into their role in TB and LTBI pathogenesis.
Neutralizing antibody responses and cellular responses against SARS-CoV-2 Omicron subvariant BA.5 after mRNA SARS-CoV-2 vaccination in kidney transplant recipients
Authors: Kawashiro Keita , Suzuki Rigel , Nogimori Takuto , Iwahara Naoya , Hirose Takayuki , Okada Kazufumi , Yamamoto Takuya , Fukuhara Takasuke , Hotta Kiyohiko , Shinohara Nobuo 
Published: January 2024

Abstract
Although the mRNA SARS-CoV-2 vaccine has improved the mortality rate in the general population, its efficacy against rapidly mutating virus strains, especially in kidney transplant recipients, remains unclear. We examined the anti-SARS-CoV-2 spike protein IgG antibody and neutralizing antibody titers and cellular immunity against B.1.1, BA.1, and BA.5 antigens in 73 uninfected kidney recipients and 17 uninfected healthy controls who received three doses of an mRNA SARS-CoV-2 vaccine. The IgG antibody titers were significantly lower in recipients than in healthy controls. Similarly, neutralizing antibody titers against three viral variants were significantly lower in recipients. When the virus was mutated, the neutralizing antibody titers decreased significantly in both groups. In cellular immunity analysis, the number of spike-specific CD8 + non-naïve T cells against three variants significantly decreased in recipients. Conversely, the frequency of spike-specific Th2 CD4 + T-cells in recipients was higher than that in healthy controls. Twenty recipients and seven healthy controls also received a bivalent omicron-containing booster vaccine, leading to increased IgG and neutralizing antibody titers in both groups. However, the increase was significantly lower in recipients. Recipients did not gain sufficient immunity with a third dose of vaccine, indicating a need to explore methods other than vaccines.
Clindamycin Derivatives: Unveiling New Prospects as Potential Anti-Tumor Agents
Authors: Jia Yiduo , zhang yinmeng , Zhu Hong 
Published: January 2024

Abstract
This study investigates the anti-tumor potential of Clindamycin derivatives, compounds 3 and 3e, through a multidisciplinary approach. Screening 200 Clindamycin-associated targets identified the Family A G-protein-coupled receptor as a prominent anti-tumor target. Subsequent analyses revealed 16 relevant anti-tumor proteins, with compound 3 demonstrating a strong association with a specific protein via stable hydrogen bonding. Molecular dynamics simulations identified adrenergic receptor β as a critical target, predominantly localized in the plasma membrane and endoplasmic reticulum. These findings suggest that compound 3 may enhance natural defense mechanisms against tumors by regulating immune responses in the tumor microenvironment, offering a potential avenue for novel anti-tumor drug development.
Radiological and clinical outcomes after Attune primary total knee arthroplasty using Stemmable Tibia: a two-year follow-up prospective bi-center study
Authors: Rhee Seung Joon , Woo Seung Hun , Kim Jung Shin , Yun Mi Sook , Park Chankue , Lee Sang-Min 
Published: January 2024

Abstract
Background
The outcomes of primary total knee arthroplasty (TKA) using the Stemmable Tibia Attune system are unknown, and this study aimed to determine these outcomes.
Methods
This prospective bi-center study enrolled 100 patients undergoing primary TKA with Stemmable Tibia between January 2019 and December 2021. Radiological outcomes (hip-knee-ankle [HKA] axis and medial proximal tibial angle [MPTA]) were assessed preoperatively and postoperatively. Clinical outcomes (visual analog scale [VAS], Hospital for Special Surgery (HSS) score, Knee Society function score [KS-FS] knee score [KS-KS]) and flexion contracture (FC), further flexion (FF), and range of motion (ROM) were analyzed preoperatively and at 6 weeks, 3 months, 6 months, 1 year, and 2 years postoperatively. Complications such as periprosthetic joint infection (PJI) and aseptic loosening were examined
Results
The HKA axis decreased from 9.2° ± 6.3° preoperatively to 0.9° ± 2.6° postoperatively, and the MPTA increased from 84.9° ± 2.6° preoperatively to 89.9° ± 2.2° postoperatively. The VAS, HSS, KS-KS, and KS-FS increased postoperatively. The KS-KS indicated excellent outcomes (70.24% and 68.33% at 1 and 2 years postoperatively, respectively); the KS-FS also showed good results (97.62% and 94.05% at 1 and 2 years postoperatively, respectively). ROM significantly improved (p < 0.001), with FC decreasing from 9.22° ± 6.85° to 2.15° ± 2.68° and FF increasing from 135.48° ± 13.73° to 141.06° ± 9.42°. One case of PJI occurred; however, no early loosening was observed.
Conclusions
Attune primary TKA with Stemmable Tibia is safe and effective, and leads to radiological and clinical improvements.
Teaching English to Economy and Finance Majors at Nakhchivan State University
Authors: Ashrafova Ilaha 
Published: January 2024

Abstract
This study explores the English language learning challenges faced by first-year economy and finance students at Nakhchivan State University. Through surveys, interviews, and academic performance analysis, the research identifies key difficulties in vocabulary, grammar, pronunciation, and listening comprehension, and their impact on academic and professional proficiency. The findings suggest the need for specialized English teaching strategies tailored to these students' specific needs.
Effect of Foreign Direct Investment on Private Domestic Investment in Ethiopia.
Authors: Wogari Takele 
Published: January 2024

Abstract
This study examines the effect of foreign direct investment (FDI) on private domestic investment in Ethiopia. This study employed annual time-series data from 1990 to 2019 for gross fixed capital formation, real gross domestic product, exchange rate, inflation, and foreign direct investment (FDI). This study adopted an autoregressive distributed lag (ARDL) approach and other econometric tools of analysis to answer the objectives set out in this study. The Augmented Dickey–Fuller test, Phillips–Perron unit root test, and bounds test method of cointegration employed indicate that the series used in the model are all stationary, with a unique long-run relationship established among the variables. The study also establishes an inverse relationship between FDI and private domestic investment within the period under reference. Using econometric procedures, the ADF unit root test revealed that some variables were integrated into the first difference. The ARDL test indicated the existence of long-run relationships among the variables. When testing for causality using the Granger causality test, the results obtained indicate that there is a unidirectional relationship between FDI and private domestic investment in Ethiopia, meaning that FDI causes private domestic investment in Ethiopia, while private domestic investment does not cause foreign direct investment. Based on the findings, the following recommendations were made: First, the concerned body should put in place policy with respect to domestic investment, and there must be safety measures to protect domestic investors from falling out of business and domestic investment promotion measures that will stimulate domestic firms’ investment. Second, in an attempt to control the birr exchange rate since it does have bearing on inflation, the government should put in place an enduring framework to strike the risk of domestic producers for them to take innovative domestic investors that will have a competitive advantage with foreign investors.
Cranial ontogeny in Steller sea lions: Relationships between cranial morphology and suction feeding
Authors: Yuge Ryunosuke , Kobayashi Yumi , Isono Takeomi , Yamamura Orio 
Published: January 2024

Abstract
Suction feeding is a specific behavior in pinnipeds such as the Steller sea lion (Eumetopias jubatus), whereas the phylogenetically related brown bear (Ursus arctos) ingests by masticatory feeding. Because these feeding modes use different organs, the morphology and ontogeny of the cranial bones of these species may be related to differences in their feeding behavior. In this study, we performed multiple regression analyses to compare the ontogeny of Steller sea lion and brown bear cranial morphology by species and sex, using age, species, and the age × species interaction as explanatory variables and site measurements standardized by cranial length as response variables. The results showed that the palatine bone in both sexes widened with age in Steller sea lions compared to brown bears, whereas the width of the zygomatic arch was less developed in female Steller sea lions than in brown bears. This result may reflect the fact that the masticatory muscles are used less during suction feeding, whereas the tongue is used to perform force-intensive tasks. These results are consistent with previous studies on Carnivora and suggest that the development of the palatine bone and underdevelopment of the zygomatic arch represent characteristics of suction feeding.
Screening of common key immune genes and prediction of potential drugs in chronic hepatic injury
Authors: Pang Ting , Fu Jing , Li Junxuan , Chen Yong , He Huan , Ma Jiabao , Liang Cao , Tang Qiulian , Hu Naiqiang , Zhao Meirong , Qin Qingxia , Wei Jiangcun 
Published: January 2024

Abstract
Studies had revealed that Immune related genes play an important role in Chronic hepatic injury (CHI), which is the main cause of liver fibrosis. Differentially expressed genes (DEGs) between CHI including Alcoholic hepatitis (AH), Nonalcoholic fatty liver disease (NAFLD), Hepatitis C (HC), and Hepatitis B (HB) and related Control samples were detected by differential analysis. Then, 77 latent genes of CHI were intersected with IRGs to obtain DEGs for generating a Protein-protein interaction (PPI) network to screen out 5 key genes consisting of secreted phosphor protein 1 (SPP1), Chemokine (C-X-C motif) ligand (CXCL10), Chemokine (C-C motif) ligand 20 (CCL20), Annexin A2 (ANXA2), and lectin galactoside-binding soluble 3 (LGALS3). Besides, we found that CXCL10 was regulated by a natural compound named quercetin, and there were 187 herbs with it as the main component. TFs-mRNA network identified that Forkhead box C1 (FOXC1) could regulate 4 key genes including CCL20, SSP1, ANXA2, and LGALS3. Therefore, this could provide references for CHI treatments and further studies.
Autoantibodies neutralizing GM-CSF in HIV-negative Colombian patients infected with Cryptococcus gattii and C. neoformans
Authors: Arango-Franco Carlos A. , Rojas Julián , Firacative Carolina , Agudelo Clara Inés , Franco José Luis , Casanova Jean-Laurent , Puel Anne , Lizarazo Jairo , Castañeda Elizabeth , Arias Andrés A. 
Published: January 2024

Abstract

Background: Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii. Autoantibodies (auto-Abs) neutralizing granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryptococcal meningitis have been described since 2013. We searched for neutralizing auto-Abs in sera from Colombian patients with non-HIV related cryptococcosis in a retrospective national cohort collected from 1997 to 2016. Methods: We reviewed clinical and laboratory records and assessed the presence of neutralizing auto-Abs in 30 HIV (-) adults presenting cryptococcosis (13 by C. gattii, and 17 by C. neoformans).
Results: We detected auto-Abs neutralizing GM-CSF in the plasma of 9 out of 13 (69%) patients infected with C. gattii and 1 out of 17 (6%) patients with C. neoformans.
Conclusions: We report ten Colombian patients with cryptococcosis due to auto-Abs neutralizing GM-CSF. Nine of the ten patients were infected with C. gattii, and only one with C. neoformans.
Factor Structure of the Multidimensional Health Perceptions Questionnaire in English- and Spanish-speakers
Authors: Juengst Shannon B. , Sander Angelle M. , Vega Marlene , Braga Maria Boix , Khera Alka , Pappadis Monique R. 
Published: January 2024

Abstract
Objective: To determine the factor structure of the Multidimensional Health Perceptions Questionnaire (MHPQ), a self-reported multidimensional assessment of health perceptions, in English-speakers and Spanish-speakers in the U.S with and without various health conditions (general population).
Methods: The MHPQ previously demonstrated excellent content validity (content validity index=98.1%) and conceptual equivalence in English and Spanish, with a reading grade level of <8th grade in both languages. We administered the original 93-item MHPQ as an anonymous survey (REDCap™) to participants in the general population (items rated on a 1=Strongly disagree to 5=Strongly agree response scale).
Results: N=357 participants completed the MHPQ (n=331 English, n=26 Spanish). The sample was 74.2% women, 18-82 years old, 24.1% Hispanic/Latino, predominantly White (68.9%), and highly educated (52.1% with at least an Associate degree). Exploratory Factor Analysis resulted in 65 final items with a multidimensional structure and good internal consistency reliabilities, with the following seven health perceptions domains (% variance, Cronbach’s α): Anticipated Discrimination and Judgement (18.9%, α=.92); Spiritual Health Beliefs (8.6%, α=.89); Social and Emotional Well-being (5.5%, α=.71); Confidence in Healthcare Providers and Medicine (3.5%, α=.85); Health Self-Efficacy (2.9%, α=.79); Trust in Social Health Advice (2.8%, α=.74); and Health Literacy (2.2%, α=.86).
Conclusions: Results suggest that the MHPQ may be a valid and reliable measure for comprehensively characterizing health beliefs in the general population. Future work should validate the MHPQ in specific populations.
Distinct sources of resting-state EEG microstates in amyotrophic lateral sclerosis
Authors: Metzger  , Dukic  , McMackin  , Giglia  , Mitchell  , Bista  , Tadjine  , Sirenko  , Plaitano  , Coffey  , McManus  , Sharp Farnell , Mehra  , Heverin  , Bede  , Muthuraman  , Pender  , Hardiman  , Nasseroleslami  
Published: January 2024

Abstract
Brain microstates are a well-established method for the dynamic analysis of resting-state electroencephalogram (EEG). We observed four quasi-stable, transient and reoccurring resting-state topographies in the high density EEG data (128 electrodes, 3x2 min recording blocks). The four microstates were reliably observed across conditions: individuals with Amyotrophic lateral sclerosis (ALS) (n = 99) versus age-matched healthy controls (HC, n = 78).
To improve the understanding of the neural mechanisms underlying microstates, we estimated the sources of microstates topographies. A general linear model was applied to predict the microstate sequence based on EEG-estimated source space time courses. High reproducibility across participants of influential brain sources led to the identification of four microstate specific networks. Some brain regions contributed to several microstate networks, which may indicate that these regions (including the precuneus, the superior frontal gyrus and the hippocampus) are functional neuronal ‘hubs’ of connection. Additionally, distinct source patterns were observed between ALS patients and healthy controls, highlighting potential functional changes in the brain networks in ALS.
Development of a multi-sensor biologging collar and analytical techniques to describe high-resolution spatial behavior in free ranging terrestrial mammals
Authors: Painter Michael S , Silovský Václav , Blanco Justin , Holton Mark , Faltusová Monika , Wilson Rory , Börger Luca , Psotta Liza , Almodovar Fabian Ramos , Estrada Luis , Landler Lukas , Malkemper E. Pascal , Hart Vlastimil , Ježek Miloš 
Published: January 2024

Abstract
1. Biologging has proven to be a powerful approach to investigate diverse questions related to movement ecology across a range of spatiotemporal scales and increasingly relies on multidisciplinary expertise. Advancements in sensor design and analytical techniques continue to push the boundaries of this emerging discipline. However, the growing variety of animal-borne equipment, coupled with little consensus regarding analytical approaches to interpret complex datasets presents challenges and makes comparison between studies and study species difficult.
2. Here, we present a combined hardware and analytical approach for standardizing the collection, analysis and interpretation of multi-sensor biologging data. We develop (i) a custom-designed integrated multi-sensor collar (IMSC), which was field tested on 71 free-ranging wild boar (Sus scrofa) over 2 years; (ii) a machine learning behavioral classifier capable of identifying six behaviors in free-roaming boar, validated across individuals equipped with differing collar designs; and (iii) laboratory and field-based calibration and accuracy assessments of animal heading measurements derived from raw magnetometer data.
3. The durability and capacity of IMSCs exceeded expectations, with a 94% collar recovery rate and a 75% cumulative data recording success rate across all collars deployed, with a maximum data logging duration of 421 days. The behavioral classifier had an overall accuracy of 85% in identifying the six behavioral classes across all collar designs and improved to 90% when tested on data from the IMSC only. Both laboratory and field tests of magnetic compass headings were in precise agreement with expectations, with overall median magnetic headings deviating from ground truth observations by 1.7° and 0°, respectively.
4. Here we present the development of the IMSC coupled with an analytical framework verified by ground truth data for identifying core behaviors and spatial orientation in free roaming boar. We highlight the potential of additional analyses available using this commercially produced system that can be adapted for use in future studies on terrestrial mammals.
Cultural landscapes, geography and resilience in four rural areas (Ourense, Spain)
Authors: Medina Xosé Somoza , Medina Marta Somoza 
Published: January 2024

Abstract
The research analyzes the cultural landscapes of four regions in Ourense, one of the provinces of Spain that suffers great problems of demographic atony, ageing, depopulation and abandonment of economic activities. Vulnerable areas that have been deactivated through the 20th century by successive migratory waves, where the loss of population and the relinquishment of agricultural and forestry plots have had severe social, economic and cultural repercussions. The work examines the resilience of these rural landscapes, where different crops have been the key element of life and trade for centuries, adapting the diferential spatial features to the more convenient exploitation of agriculture and livestock. After decades of crisis, some successful experiences show the way to certain territorial renewal based on local resources -vineyard, bread, chestnut and potato-, which were the supportative elements of the population in the past.
Adjuvant oxaliplatin-based chemotherapy comparing observation alone after radical resection of metachronous metastases of colorectal cancer: interim analysis
Authors: Evdokimova S. F. , Bolotina L. V. , Kornietskaya A. L. , Sidorov D. V. , Kaprin A. D. 
Published: January 2024

Introduction. Despite the registered standard treatment option for patients who underwent radical resection for metachronous metastases of colorectal cancer (CRC), the feasibility of adjuvant chemotherapy (ACT) for all patients seems controversial. Due to studies demonstrating improved disease-free survival rates with postoperative chemotherapy vs observation, it would seem that there is reasonable expectation of improved overall survival (OS) rates, which, however, were not statistically different between groups. This article presents the interim results of our own study.Aim. To analyse the efficacy of ACT vs dynamic observation in patients who underwent surgery for metachronous metastases of colorectal cancer.Materials and methods. It was a prospective-retrospective, non-randomized, non-inferiority study. A total of 120 patients were recruited between June 2008 and September 2022. The ACT group included 71 patients. All patients received only oxaliplatin-based chemotherapy regimens; the dynamic observation group included 49 patients.Results. The interim analysis showed that the median disease-free survival (mDFS) in the ACT group (n = 71) was 20.9 months (13.7–28.3) vs 24.4 months in the dynamic observation group (n = 49) (11.1–37.7), HR: 0.76 (95% CI: 0.45–1.29), p = 0.29. Two-year disease-free survival (DFS) rates were 46.6% in the post-surgery chemotherapy (CT) group (n = 50) and 55.5% in the experimental group (n = 31), HR: 0.69 (95% CI: 0.39–1.2), p = 0.21.Conclusion. ACT has not improved the long-term treatment outcomes in patients who underwent radical resection for metachronous metastases of CRC.