bluuebunny/crossref_metadata_2025_split huggingface dataset:
What guidance exists to support patient partner compensation practices? A scoping review of available policies and guidelines
Authors: Fox Grace , Fergusson Dean A. , Sadeknury Ahmed , Nicholls Stuart G. , Smith Maureen , Stacey Dawn , Lalu Manoj M. 
Published: January 2024

AbstractBackgroundAn integral aspect of patient engagement in research, also known as patient and public involvement, is appropriately recognising patient partners for their contributions through compensation (e.g., coauthorship, honoraria). Despite known benefits to compensating patient partners, our previous work suggested compensation is rarely reported and researchers perceive a lack of guidance on this issue. To address this gap, we identified and summarised available guidance and policy documents for patient partner compensation.MethodsWe conducted this scoping review in accordance with methods suggested by the JBI. We searched the grey literature (Google, Google Scholar) in March 2022 and Overton (an international database of policy documents) in April 2022. We included articles, guidance or policy documents regarding the compensation of patient partners for their research contributions. Two reviewers independently extracted and synthesised document characteristics and recommendations.ResultsWe identified 65 guidance or policy documents. Most documents were published in Canada (57%, n = 37) or the United Kingdom (26%, n = 17). The most common recommended methods of nonfinancial compensation were offering training opportunities to patient partners (40%, n = 26) and facilitating patient partner attendance at conferences (38%, n = 25). The majority of guidance documents (95%) suggested financially compensating (i.e., offering something of monetary value) patient partners for their research contributions. Across guidance documents, the recommended monetary value of financial compensation was relatively consistent and associated with the role played by patient partners and/or specific engagement activities. For instance, the median monetary value for obtaining patient partner feedback (i.e., consultation) was $19/h (USD) (range of $12–$50/h). We identified several documents that guide the compensation of specific populations, including youth and Indigenous peoples.ConclusionMultiple publicly available resources exist to guide researchers, patient partners and institutions in developing tailored patient partner compensation strategies. Our findings challenge the perception that a lack of guidance hinders patient partner financial compensation. Future efforts should prioritise the effective implementation of these compensation strategies to ensure that patient partners are appropriately recognised.Patient or Public ContributionsThe patient partner coauthor informed protocol development, identified data items, and interpreted findings.
The oral and systemic health impact profile for periodontal disease (OSHIP‐Perio)—Part 1: development and validation
Authors: Wong Li Beng , Yap Adrian Ujin , Sim Yu Fan , Allen Patrick Finbarr 
Published: January 2024

AbstractObjectivesThis study aimed to develop and validate the Oral and Systemic Health Impact Profile for Periodontal Disease (OSHIP‐Perio), a disease‐specific instrument for assessing the impact of periodontal disease on both general and oral health‐related quality of life.MethodsA pool of 58 items, developed from the Oral Health Impact Profile (OHIP‐49) and data generated through semi‐structured patient interviews, was tested on 80 case subjects with periodontal disease and 80 control subjects. The dimensionality of the preliminary measure was evaluated using exploratory factor analysis (EFA). Rasch analysis was then performed on the primary dimension using the Winsteps software (Version 5.1.4.0) to render the final items for the OSHIP‐Perio. The reliability and validity of the final OSHIP‐Perio were subsequently determined.ResultsUsing an EFA factor loading >0.50, the primary dimension comprised 18 items. Using Rasch analysis, four items were subsequently excluded. The final OSHIP‐Perio with 14 items showed excellent test–retest reliability (overall intraclass correlation coefficient index = 0.99) and internal consistency (overall Cronbach's alpha coefficient = 0.96). It also exhibited good discriminant validity when case and control groups were compared (p < 0.001). It showed very strong correlations (rho coefficients >0.90) with the OHIP‐5, OHIP‐14 and OHIP‐49, exhibiting good concurrent validity. It demonstrated a moderate correlation (rho coefficient = 0.60) with the global health rating, exhibiting a moderate convergent validity.ConclusionsThe 14‐item OSHIP‐Perio exhibited good psychometric properties comparable to the OHIP‐5, OHIP‐14 and OHIP‐49 for evaluating the impact of periodontal disease on quality of life.
Mechanical properties of SiCf/SiC composites with h‐BN interphase formed by the electrophoretic deposition method
Authors: Yoshida Katsumi , Kasakura Mayuko , Gubarevich Anna , Kotani Masaki 
Published: January 2024

AbstractSilicon carbide fiber–reinforced silicon carbide (SiCf/SiC) composites have been expected to be used as next‐generation heat resistant structural materials with high reliability. The fiber/matrix interface for SiCf/SiC composites plays an important role for toughening and strengthening, and it is important to form the optimal interphase for SiCf/SiC composites. In this study, hexagonal‐boron nitride (h‐BN), which shows better oxidation resistance than carbon, was selected as the interphase for SiCf/SiC composites, and h‐BN coating was formed on low‐conductive SiC fibers by the electrophoretic deposition (EPD) method using flaked h‐BN suspension prepared by wet‐jet milling. Unidirectional SiCf/SiC composites with the BN interphase formed by the EPD method were prepared by polymer impregnation and pyrolysis (PIP) method, and their mechanical properties were evaluated. The uniform h‐BN interphase was successfully formed on the low‐conductive SiC fibers by EPD when thin polypyrrole (Ppy) coating, that is, conductive polymer, was formed on the SiC fibers. The h‐BN coating became denser by heat‐treatment at 1000°C, and the h‐BN coating deposited tightly on the SiC fibers was confirmed. It was demonstrated that the SiCf/SiC composites with the uniform and relatively dense h‐BN interphase formed by EPD using flaked h‐BN particles exhibited pseudo‐ductile fracture behavior with large amount of fiber pullout and higher fracture energy.
Fabrication and characterisation of pea protein isolate‐chlorogenic acid nanoparticles
Authors: Liang Luodan , Cao Weiwei , Li Linlin , Liu Wenchao , Wei Xinyu , Chen Junliang , Ren Guangyue , Zhao Yike , Duan Xu 
Published: January 2024

SummaryChlorogenic acid (CA) is a natural antioxidant with multiple biological activities, but its stability is poor. In this article, CA‐load pea protein nanoparticles (PPCNPs) were constructed by an anti‐solvent method to enhance CA stability and characterised by multiple technologies. The results exhibited that the particle size of PPCNPs ranged from 211.62 to 429.79 nm, and the zeta potential ranged from −41.21 to −35.85 mV. PPCNPs had the highest encapsulation efficiency (61.2%) at the CA/pea protein isolate (PPI) mass ratio of 1:20. The loading capacity increased with the ratio of CA/PPI ranging from 1.3% to 3.8%. SEM showed that the nanoparticle surface was an irregular lamellar structure. FTIR showed that O–H and C–H functional group interactions occurred between CA and PPI. DSC results showed that CA was encapsulated in PPCNPs with an amorphous structure. During in vitro digestion, the ABTS radical scavenging ability and retention ratio of CA in PPCNPs was higher than that of free CA. Moreover, PPCNPs increased the bio‐accessibility of CA in vitro by 7.75%, compared with unencapsulated CA. These results suggested that PPCNPs constructed by the anti‐solvent method can reduce the degradation of CA and improve the biological activity of CA.
CO2‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua
Authors: Ai Rong , Ettoumi Fatima‐Ezzahra , Ma Yueran , Li Dong , Lv Weide , Luo Zisheng 
Published: January 2024

SummaryThe integration of carbon dioxide‐nanobubbles (CO2‐NBs) with cellulase has led to the development of an innovative extraction system for phenolic compound retrieval from P. cyrtonema (Polygonatum cyrtonema) Hua rhizomes. Four critical factors influencing on CO2‐NBs‐cellulase were methodically investigated and optimised through single‐factor experiments. The optimal experimental conditions are 30 cycles, 0.35 MPa, pH 5.45 and 0.025 g/mL cellulase aqueous solution. The stability of system was characterised meticulously, indicating the viability for at least 24 h. Comparative assessment of bioactive constituents and antioxidant activity demonstrated exceptional extraction efficiency and potential synergistic effects of CO2‐NBs‐cellulase. Synergistic effects and reaction mechanisms during extraction were explored using Fourier‐transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy, which contributed to mechanism understanding with significant alterations in partial structure and heightened thermal stability we found. In essence, this study introduces an eco‐friendly, energy‐efficient extraction system paradigm based on a novel nanobubble‐enzyme binding approach.
High entropy oxide as interfacial material for toughened textured alumina
Authors: Liu Junbo , Ma Zhuoran , Behera Rohit Pratyush , He Hongying , Xiong Ji , Le Ferrand Hortense 
Published: January 2024

AbstractTextured alumina ceramics with brick‐and‐mortar microstructures exhibit surprisingly high values of strength and toughness as compared to traditional ceramics. However, in full ceramic systems, pressure‐assisted sintering restricts their shaping potential, and the study of interfacial materials is still insufficient. Here, we fabricate textured alumina exhibiting elevated indentation fracture toughness using a high entropy oxide (HEO) (MgAlSiTiZr)O as the mortar. The HEO undergoes a single‐phase transformation at 1600°C, resulting in a crystallographic structure identical to that of ZrO2. Our HEO mortar is tough and has a high wetting behavior to alumina platelets used in the green body, which promotes densification via liquid phase sintering. Textured alumina ceramics with HEO mortar at concentrations varying from 0 to 90 wt% were fabricated using magnetically assisted slip casting and pressureless sintering through the templated grain growth process. A trade‐off between density and grain anisotropy led to the highest mechanical properties. Textured alumina with 10 wt% HEO exhibited over 95% relative density, an elastic modulus of 244 ± 29 GPa, a flexural strength of 329 ± 27 MPa, and an indentation fracture toughness of 6.80 ± 0.65 MPa∙m0.5, which is more than 1.9 times that of the usual polycrystalline alumina. Thanks to the mineral nature of HEO, the simplicity of the process, and the mechanical properties, the textured alumina with HEO mortar can be produced in complex shapes and could find applications in stringent environments.
An Iapetus origin for a layered eclogite complex in the northern Western Gneiss Region, Scandinavian Caledonides
Authors: Möller Charlotte , Cai Yue , Brueckner Hannes K. , Szilas Kristoffer , Whitehouse Martin J. 
Published: January 2024

AbstractThe Western Gneiss Region (WGR) is a Precambrian basement domain in the Scandinavian Caledonides and one of the world's largest high‐ and ultrahigh‐pressure terranes. The south–central WGR underwent regional eclogite facies metamorphism 415–400 Ma ago when Baltica subducted beneath Laurentia, during the Scandian orogeny. Eclogites in the WGR group into two traditional types: (1) Precambrian mafic intrusions metamorphosed in situ during Scandian continental subduction and (2) eclogites, garnet peridotites and garnet pyroxenites within ultramafic complexes derived from the subcontinental mantle beneath Laurentia. We document, using field relations, petrography, whole‐rock geochemistry and secondary ion mass spectrometry (SIMS) zircon geochronology, a hitherto unrecognized third type of eclogite in the WGR that places new constraints on its tectonic architecture: an eclogitized fragment of oceanic crust from the Iapetus Ocean. The Kråkfjord eclogite complex is a km2‐sized body with an interior consisting of kyanite eclogite (meta‐troctolite) and subordinate layers and lenses of garnet peridotite, garnet websterite and kyanite–garnet leucotonalite. This interior is capped by Fe–Ti‐rich eclogite, which locally contains subordinate pockets of migmatitic aluminous gneiss. The elemental abundances and isotopic compositions of the Fe–Ti‐rich eclogites resemble those of mid‐ocean ridge basalt (MORB). In contrast, the interior kyanite eclogites, peridotites and pyroxenites have compositions similar to the gabbroic cumulates in the lower oceanic crust of slow‐spreading ridges. U–Pb SIMS dating of igneous zircon cores from a leucotonalite pod in the interior of the Kråkfjord complex yields Cambro‐Ordovician igneous ages of 500–440 Ma, with the ~500 Ma age interpreted as the isotopically undisturbed age. This age matches those of Iapetan oceanic rocks exposed elsewhere in the mountain belt. Metamorphic zircon from an Fe–Ti‐rich eclogite in the carapace of the Kråkfjord complex dates the eclogite facies metamorphism at 421.9 ± 2.2 Ma, synchronous with the continental collision. Zircon from a leucosome in Fe–Ti‐rich retro‐eclogite indicates an age of 408.5 ± 2 Ma for the crystallization of partial melt following the decompression. Detrital zircon core ages from a pocket of aluminous migmatitic gneiss in the carapace indicate derivation of sediment from the Baltic crust. Collectively, the data show that the eclogite complex (1) originated at an Iapetus spreading centre near the continent Baltica, (2) subducted to eclogite conditions during Scandian continental collision and (3) was tectonically intercalated with the Precambrian Baltica basement of the WGR.
Comparative morphology of oral glands in snakes of the family Homalopsidae reveals substantial variation and additional independent origins of salt glands within Serpentes
Authors: de Oliveira Leonardo , Gower David J. , Wilkinson Mark , Segall Marion 
Published: January 2024

AbstractUsing diffusible iodine‐based contrast‐enhanced computed tomography (diceCT), we examined the morphology of the oral glands of 12 species of the family Homalopsidae. Snakes of this family exhibit substantial interspecific morphological variation in their oral glands. Particular variables are the venom glands, ranging from large (e.g., Subsessor bocourti) to small (e.g., Erpeton tentaculatum). The supra‐ and infralabial glands are more uniform in morphology, being the second most developed in almost all the sampled species. Premaxillary glands distinct from the supralabial glands were observed in five species (Myron richardsonii, Bitia hydroides, Cantoria violacea, Fordonia leucobalia, and Gerarda prevostiana), in addition to Cerberus rynchops, the only species in which this condition was previously documented associated with the excretion of salt. In the three species of the saltwater group of homalopsids (C. violacea, F. leucobalia, and G. prevostiana), the premaxillary glands also extend posteriorly, occupying a large area above the supralabial gland, a condition not observed in any other species of snake studied thus far. Character evolution analyses indicate that premaxillary glands differentiated from the supralabial gland and evolved independently three or four times in the family, always in lineages that invaded marine habitats. Our results suggest that the differentiated premaxillary glands are likely salt glands, as is the case in C. rynchops. If corroborated, this increases to six or seven the number of independent evolutionary origins of salt glands in snakes that have undergone an evolutionary transition to marine life.
Cultural shock of high‐speed rail: Evidence from social trust
Authors: Chen Fanglin , Chen Zhongfei 
Published: January 2024

AbstractThe opening of high‐speed rail (HSR), as an exogenous shock, has had a profound and complex effect on social life. This study analyzes the effect of the opening of HSR on social trust. Results show that the opening of HSR promotes social trust. Mechanism analysis showed that although the opening of HSR accelerated population mobility and decreased trust in strangers, economic growth and improvement of local social issues mitigated the negative effects of its opening. In addition, our results also show that individuals turn to trust in their parents, neighbors, and doctors. Considering the potential endogeneity problem, instrumental variable and difference‐in‐differences estimators consistently indicated the promoting effect of the HSR opening on trust. Heterogeneity analysis showed that the opening of HSR had a greater effect on female, urban residents, younger groups, and married people. Last, cities with larger populations and tourist cities were more vulnerable to shocks.
Prevalence of hepatitis C among pregnant women in an Appalachian population
Authors: Pollock Taylor S. , Robert Chris A. , Seybold Dara J. , Hur Marisa , Broton Alina , Calhoun Byron C. 
Published: January 2024

AbstractThe opioid crisis has adversely affected West Virginia's pregnant and infant populations. With high rates of opioid use disorder and neonatal abstinence syndrome, West Virginia has the highest rates of Hepatitis C (HCV) acute infection among pregnant women. To better understand how HCV impacts an already high‐risk population, the study purpose was to (1) describe its prevalence among women receiving prenatal care at a single tertiary care clinic in Appalachia and compare with state and national rates, and (2) determine whether it is associated with preterm birth (gestation <37 weeks). Data were collected on a retrospective cohort of pregnant patients universally screened for HCV between 2017 and 2021. The study cohort had an HCV infection rate of 119/988 = 11.94% or 119.4 per 1000. This is five times the rate of 22.6 per 1000 live births in West Virginia in 2014 and 35 times the national rate of 3.4 per 1000 live births (MMWR Morb Mortal Wkly Rep 66, 2017 and 470). Viral loads were detected in 63 (6.38%) of patients. The study cohort with birth outcome data had high rates of tobacco use (326/720; 45.3%) and substance abuse (209/720; 29.0%). The preterm birth rate was 17.8% (128/720), almost double the national average (10.09%) (Natl Vital Stat Rep 70, 2021 and 1). There was no statistically significant difference in preterm birth between HCV‐positive (15/92; 16.3%) and HCV‐negative (113/628; 18.0%) patients. HCV infection in our population presents a significant public health issue and missed opportunity for treatment in a population with continuity of care challenges. These findings could be used to justify a pilot program for early postpartum referral for treatment.
Hsa_circ_0010882 facilitates hepatocellular carcinoma progression by modulating M1/M2 macrophage polarization
Authors: Yang Ming , Yu Tao , Han Li 
Published: January 2024

AbstractHepatocellular carcinoma (HCC) is one common malignant tumour with a high immunosuppressive tumour microenvironment and poor outcomes. This study investigated the influence of hsa_circ_0010882 on M1/M2 macrophage polarization in the progression of HCC. A total of 125 paired tissue specimens from HCC patients who underwent hepatectomy were collected. M1 and M2 phenotypes macrophages were induced using THP‐1. After co‐cultured with macrophages and transfected HCC cells, the viability, migration and invasion of HCC cells were detected by cellular experiments. Bioinformatic databases and dual‐luciferase reporter assays were used to predict and validate the interaction between circ_0010882 and miR‐382. Expression of circ_0010882 was increased in HCC tissues and associated with shorter overall survival outcomes. The mRNA expression of M2 macrophage markers Arg‐1, CD163 and CD206 were elevated in HCC tissues. Interfering with circ_0010882 increased M1‐type macrophage markers (TNF‐α and iNOS) while decreasing M2‐type macrophage markers (Arg‐1 and CD206). Silencing of circ_0010882 strengthened the capacity of M1 macrophages to suppress HCC cell viability, migration capacities and invasion potential while reducing the ability of M2 macrophages to promote above cellular abilities. MiR‐382 was a direct target miRNA of circ_0010882. The circ_0010882 expression was increased in HCC tissues and associated with poor prognosis of HCC patients. Silencing of circ_0010882 inhibits macrophage M2 polarization in HCC progression by regulating miR‐382 expression. Circ_0010882 may serve as a biomarker to provide novel strategies for the treatment of HCC and patient rehabilitation, thereby improving the prognosis of patients.
Near or far: revision of distribution, breeding and winter ranges of two sibling Pipistrellus species (Chiroptera, Vespertilionidae) in Eastern Europe and the Caucasus
Authors: Godlevska Lena , Gazaryan Suren 
Published: January 2024

Abstract

Knowledge of species distribution and, for migratory species, seasonal occurrence is particularly important for vulnerable and protected animals such as bats. The former European bat species Pipistrellus pipistrellus was split into two, Pipistrelus pipistrellus s.s. and Pipistrelus pygmaeus, over 20 years ago. However, their distribution, breeding and winter ranges as well as migratory status in Eastern Europe and the Caucasus remained obscure.

In our study, we scrutinised records of both species and assessed the sex ratio during their breeding season in this region.

We show that Pipistrellus pipistrellus s.s. has a significantly smaller range than previously assumed, being restricted to the southern part of the study area. On the contrary, Pipistrelus pygmaeus has a broader distribution, covering the Caucasus and Eastern Europe, up to ca. 59° N. Hence, all historical records and long‐distance movements of Pipistrellus pipistrellus sensu lato from Eastern Europe within the inferred allopatric occurrence of Pipistrelus pygmaeus should be attributed to Pipistrelus pygmaeus.

The high portion of adult males in breeding localities, mass wintering within the breeding range and lacking evidence of long‐distance seasonal movements imply that Pipistrellus pipistrellus s.s. is a sedentary species. In Pipistrelus pygmaeus, the sex ratio among adults during the breeding season varies latitudinally. The female‐biased sex ratio, absence of mass wintering and the historical long‐distance recoveries of ringed individuals suggest that this species is migratory in Eastern Europe. The male‐biased sex ratio during the breeding season, along with late autumn records, suggests that the Caucasus represents its winter range.