Effect of olive olive extracts in myocardial and vascular function of patients with chronic cononary syndromes
Authors: Ikonomidis I , Katogiannis K , Pavlidis G , Thymis J , Kostelli G , Michalopoulou H , Katsanaki H , Vlachomitros D , Christodoulou A , Tsoumani M , Tseti J , Andreadou J 
Published: January 2025

Abstract

Introduction
In a recent study, we demonstrated that the administration of an olive oil supplement enriched with HT (Olivomed) reduces oxidative stress and inflammatory biomarkers, improves endothelial and arterial function, and facilitates the diastolic function of the left ventricle after a short treatment period in patients with chronic coronary syndromes.

Objetive
Wehypothesized that the administration of an oral supplement, Olivomed SMART, containing olive oil extract enriched with oleuropein (OL), hydroxytyrosol (HT) and oleocanthal (OLEO), can reduce oxidative burden and further improve cardiac and vascular markers in patients with chronic coronary syndromes.

Method
Thus, in a prospective, randomized, crossover, double-blind, placebo-controlled clinical trial, we randomized 15 patients with chronic coronary syndromes to an oral supplement of olive oil extract enriched with OL, HT, and OLEO in a ratio of 2:1:3 or a placebo for one month. We measured before treatment, one month after using the placebo, and one month after administering the olive supplement:
a) the Perfused Boundary Region (PBR) related inversely to the thickness of the endothelial glycocalyx in sublingual arterioles (range 5–25 μm), a marker inversely related to glycocalyx thickness,
b) endothelial-dependent vasodilation (FMD) of the brachial artery,
c) flow reserve in the anterior descending (CFR) with Doppler echocardiography,
d) pulse wave velocity (PWV), central systolic blood pressure (cSBP),
e) concentration of malondialdehyde (MDA), an oxidative stress marker.

Results
It appears that the administration of the Olivomed SMART supplement significantly improves vascular markers FMD and CFR compared to baseline, while no changes are induced by the placebo (Table 1). Olivomed SMART improves diastolic function, as shown by improved values of E’, E/e’, DT, LVGLS. No significant no marker indicates any difference compared to baseline (Table 2).
The administration of the Olivomed SMART supplement significantly reduced levels of the oxidative stress marker MDA and oxidized LDL cholesterol in serum compared to baseline. In contrast, no statistically significant changes were observed after placebo administration (Table 3).
Comparing the action of Olivomed and Olivomed SMART on the main vascular, echocardiographic, and biochemical markers relative to baseline values before treatment, the following table (Table 4) shows significant changes after the administration of Olivomed SMART in left ventricular longitudinal strain values and glycocalyx integrity in vessels ranging 20-25 μm.

Conclusion
Comparing Olivomed and Olivomed SMART, it appears that the beneficial effects on vascular and cardiac properties are largely due to the action of HT, while the newer combined formulation seems to provide additional benefits in endothelial function of arterioles, coronary artery function, and myocardial strain through the reduction of oxidative stress.