bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of open lung biopsy in the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies
Authors: Kim Kihyun , Lee Mark H. , Kim Jingook , Lee Kyung Soo , Kim Sung Min , Jung Man Pyo , Han Joungho , Sung Ki Woong , Kim Won Seog , Jung Chul Won , Yoon Sung Soo , Im Young‐Hyuck , Kang Won Ki , Park Keunchil , Park Chan Hyung 
Published: October 2002

AbstractInvasive pulmonary aspergillosis is a serious infectious complication in immunocompromised patients. Recent reports indicate its favorable clinical outcomes by early diagnosis with chest computed tomography scan. We retrospectively analyzed our experiences with histopathological evaluation by open lung biopsy in 31 patients (32 cases) with hematologic malignancies, suspected of having invasive pulmonary aspergillosis clinically and radiologically. Although the initial computed tomography findings of all cases were highly indicative of invasive pulmonary aspergillosis by demonstrating nodules or masses with a halo sign (16 cases), segmental area of consolidation with ground‐glass attenuation (7 cases), both nodules or masses with a halo sign and segmental area of consolidation with ground‐glass attenuation (7 cases) and poorly defined centrilobular nodules (2 cases), we could histopathologically confirm invasive fungal infections only in 17 cases (53.1%) by open lung biopsy. There were 13 cases of invasive pulmonary aspergillosis, two cases of aspergilloma, and two cases of mucormycosis. No fungal hyphae were found in the other 15 cases: organizing pneumonia in seven cases, pulmonary hemorrhage in three cases, brochiolitis obliterans with organizing pneumonia in two cases, and CMV pneumonia, pulmonary tuberculosis, candida pneumonia in one case each, respectively. We could perform open lung biopsy without mortality and significant morbidity. In view of the low positive predictive value of chest computed tomography scan and the very low morbidity of open lung biopsy, this procedure is recommendable for the diagnosis of invasive pulmonary aspergillosis and determination of its treatment. Am. J. Hematol. 71:75–79, 2002. © 2002 Wiley‐Liss, Inc.
Testicular plasmacytoma: Report of a case and review of the literature
Authors: Anghel Gabriel , Petti Nicola , Remotti Daniele , Ruscio Carla , Blandino Fortunato , Majolino Ignazio 
Published: October 2002

AbstractPlasmacytomas of the testis are rare neoplasias; they may occur as isolated tumors or in concomitance with generalized multiple myeloma. We report the case of a 77‐year‐old man with previous clinical evidence of multiple myeloma involving skin, ribs, and lungs, and initially treated with surgery, radiotherapy, and chemotherapy attaining partial response. Fourteen months after the onset, the patient presented with left testicular enlargement due to plasmacytoma. Immunohistochemical stains showed monoclonal cytoplasmic IgA‐λ in tumour cells; serum M component showed the same immunoglobulin. Following radiotherapy the tumour mass disappeared. Nonetheless, 2 months later while on chemotherapy, disease recurred with progressive increase of skeletal lesions. The patient is currently alive with disease progression 22 months after onset. On the basis of a review of the literature, the clinical significance of testicular myeloma localization is discussed. Am. J. Hematol. 71:98–104, 2002. © 2002 Wiley‐Liss, Inc.
Successful treatment of severe thrombotic thrombocytopenic purpura with the monoclonal antibody rituximab
Authors: Chemnitz Jens , Draube Andreas , Scheid Christof , Staib Peter , Schulz Armin , Diehl Volker , Söhngen Dietmar 
Published: October 2002

AbstractThe only established treatment for patients with thrombotic thrombocytopenic purpura (TTP) is plasma exchange against fresh frozen plasma. For cases refractory to plasma exchange, no generally treatment schedule exists. One option is immunosuppressive therapy with corticosteroids and vincristine. Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen, and it has been successfully used in B‐cell malignancies and is being investigated in autoimmune diseases. Its efficacy in TTP has not yet been determined. We report two female patients with severe TTP refractory to multiple courses of plasmapheresis, high‐dose steroid treatment, and vincristine who responded after adding rituximab while continuing plasmapheresis. Am. J. Hematol. 71:105–108, 2002. © 2002 Wiley‐Liss, Inc.
FG syndrome: Linkage analysis in two families supporting a new gene localization at Xp22.3 [FGS3]
Authors: Dessay Sabine , Moizard Marie Pierre , Gilardi Jean Louis , Opitz John M. , Middleton‐Price Helen , Pembrey Marcus , Moraine Claude , Briault Sylvain 
Published: October 2002

AbstractFG syndrome (OMIM 305450) is an X‐linked condition comprising mental retardation, congenital hypotonia, constipation or anal malformations, and a distinctive appearance with disproportionately large head, tall and broad forehead, cowlicks and telecanthus. In a first linkage analysis carried out on 10 families, we demonstrated heterogeneity and assigned one gene [FGS1] to region Xq12–q21.31 [Briault et al., 1997: Am J Med Genet 73:87–90] corroborated by Graham et al. [1998: Am J Med Genet 80:145–156]. Heterogeneity was supported by the study of one family with apparent FG syndrome co‐segregating with an inversion of X chromosome [inv(X)(q11q28)] ([FGS2], OMIM 300321) [Briault et al., 1999: Am J Med Genet 86:112–114 and Briault et al., 2000: Am J Med Genet 95:178–181]. We present the results of a new linkage analysis carried out on two families with FG syndrome. The two earlier known loci for FG syndrome, FGS1 and FGS2 (Xq11 or Xq28) were excluded by multipoint analysis of both families. Linkage was found, however, with locus DXS1060 suggesting that a third FG locus might be located at Xp22.3. In this region, two potential candidate genes, VCX‐A and PRKX, were excluded by sequence analysis of the coding region in patients of the two reported FG families. The search for new candidate genes is in progress. © 2002 Wiley‐Liss, Inc.
Dysmorphic features and learning disability in an adult male with pure partial trisomy 17q24‐q25 due to a terminal duplication
Authors: Kelly Brendan D. , Becker Kristin , Kermode Victoria , Stallings Raymond L. , Murphy Raymond P. , Green Andrew J. , Hillery John 
Published: October 2002

AbstractWe describe an adult male with severe learning disability, epilepsy, and dysmorphic features. Cytogenetic studies demonstrated a terminal duplication of the long arm of chromosome 17, resulting in partial trisomy 17q24‐q25. Our patient shows some of the characteristic features of the distal 17q phenotype, but in addition has more unusual features such as epilepsy, sensorineural hearing loss, and long fingers and overlapping toes. We suggest that these features occur with terminal duplications of 17q. © 2002 Wiley‐Liss, Inc.
Subtelomeric FISH uncovers trisomy 14q32: Lessons for imprinted regions, cryptic rearrangements and variant acrocentric short arms
Authors: Sutton V. Reid , Coveler Karen J. , Lalani Seema R. , Kashork Catherine D. , Shaffer Lisa G. 
Published: October 2002

AbstractThe recent development of a set of chromosome‐specific, subtelomeric probes has proved useful in diagnosis and recurrence risk counseling of patients and families with mental retardation and in further characterization of known chromosomal abnormalities. Cases of cryptic, subtelomeric rearrangements may account for up to 7.5% of cases of idiopathic moderate–severe mental retardation. We present the molecular cytogenetic studies of trisomy 14q detected by subtelomeric fluorescence in situ hybridization (FISH). Our patient is a 3‐year‐old girl with growth and developmental delay, myelomeningocele, partial agenesis of the corpus callosum, hypertelorism, tented mouth, simple ears, small mandible, and congenital heart disease (atrial and ventricular septal defects with subaortic conus). G‐banded chromosome analysis was apparently normal. A set of FISH‐based, subtelomeric, region‐specific probes revealed trisomy for 14q in the child. Parental FISH studies established that the mother is a balanced carrier for a half‐cryptic translocation between the distal long arm of chromosome 14 and the short arm of chromosome 22. FISH analysis using two BAC clones that contain the imprinted genes MEG3 and DLK1, which localize to 14q32, established that our patient has two maternal copies of these genes. Because the child does not have features of the maternal UPD 14 syndrome, this case suggests that it is absence of expression of a paternally expressed gene, rather than overexpression of a maternally expressed gene, that is responsible for the maternal UPD 14 phenotype. © 2002 Wiley‐Liss, Inc.
P63 gene mutations and human developmental syndromes
Authors: Brunner Han G. , Hamel Ben C.J. , Bokhoven Hans van 
Published: October 2002

AbstractThe P63 gene is a recently discovered member of the p53 family. While P53 is ubiquitously expressed, p63 is expressed specifically in embryonic ectoderm and in the basal regenerative layers of epithelial tissues in the adult. Complete abrogation of P63 gene function in an animal model points to the relevance of P63 for the proper development of ectodermally derived tissues. The p63 knockout mouse dies at birth and has truncation of the limbs, as well as absence of epidermis, prostate, breast, and urothelial tissues, apparently reflecting ectodermal stem cell loss. A number of dominant human syndromes have been mapped to chromosome 3q27 and ultimately to mutations in the p63 gene. These syndromes have abnormal limb development and/or ectodermal dysplasia and include ectrodactyly, ectodermal dysplasia, clefting syndrome; ankyloblepharon, ectodermal dysplasia, clefting syndrome; acro‐dermato‐ungual‐lacrimal‐tooth syndrome; limb‐mammary syndrome; as well as nonsyndromic split hand/foot malformation. The pattern of heterozygous mutations is distinct for each of these syndromes. Consistent with this syndrome‐specific mutational pattern, the functional consequences of mutations on the p63 proteins also vary, invoking dominant‐negative and gain‐of‐function mechanisms rather than a simple loss of function. © 2002 Wiley‐Liss, Inc.
Myoclonus–dystonia syndrome: ε‐sarcoglycan mutations and phenotype
Authors: Asmus Friedrich , Zimprich Alexander , Tezenas Du Montcel Sophie , Kabus Christian , Deuschl Günther , Kupsch Andreas , Ziemann Ulf , Castro Mirna , Kühn Andrea A. , Strom Tim M. , Vidailhet Marie , Bhatia Kailash P. , Dürr Alexandra , Wood Nicholas W. , Brice Alexis , Gasser Thomas 
Published: October 2002

AbstractMutations in the gene for ε‐sarcoglycan (SGCE) have been found to cause myoclonus‐dystonia syndrome. We now report clinical and genetic findings in nine additional European families with myoclonus‐dystonia syndrome. The clinical presentation in 24 affecteds was homogeneous with myoclonus predominantly of neck and upper limbs in 23 of them and dystonia, presenting as cervical dystonia and/or writer's cramp, in 13 cases. Six novel and one previously known heterozygous SGCE mutations were identified. SGCE deficiency seems to be the common pathogenetic mechanism in myoclonus‐dystonia syndrome.
A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees
Authors: Arai Aki , Tanaka Keiko , Ikeuchi Takeshi , Igarashi Shuichi , Kobayashi Hisashi , Asaka Tomoya , Date Hidetoshi , Saito Masaaki , Tanaka Hajime , Kawasaki Sari , Uyama Eiichiro , Mizusawa Hidehiro , Fukuhara Nobuyoshi , Tsuji Shoji 
Published: October 2002

AbstractDistal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive muscular disorder characterized by weakness of the anterior compartment of the lower limbs with onset in early adulthood and sparing of the quadricep muscles. The UDP‐N‐acetylglucosamine‐2‐epimerase/N‐acetylmannosamine kinase (GNE) gene was recently identified as the causative gene for hereditary inclusion body myopathy (HIBM). To investigate whether DMRV and HIBM are allelic diseases, we conducted mutational analysis of the GNE gene of six Japanese DMRV pedigrees and found that all the pedigrees share a homozygous mutation (V572L) associated with a strong linkage disequilibrium, suggesting a strong founder effect in Japanese DMRV pedigrees.
Role of sand on curing of partex surface by UV radiation
Authors: Mizanur Rahman M. , Khan Mubarak A. , Mustafa A. I. 
Published: October 2002

AbstractA partex surface was modified by a UV‐curing system with epoxy acrylate (EB‐600). A set of formulations was prepared with oligomer and the trifunctional monomer trimethylol propane triacrylate in different combinations of percentages (1–5%) of sand to study the role of sand in various physical properties of UV‐cured thin films, as well as partex surfaces. Increased pendulum hardness (PH), gloss, adhesion, and abrasion values were obtained by the addition of sand into the partex surfaces. The best results were obtained with the formulation containing 3% sand. An enhanced PH and a decreased percentage of gel content of the UV‐cured film was observed with an increase of the sand concentration. A simulated weathering test was performed with partex surfaces cured by a formulation containing 3% sand in the base coat. The losses of the physical properties were found to be lower over the surface treated with the formulation containing sand. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2385–2392, 2002
A study on morphology and physical properties of natural–acrylic rubber blends
Authors: Wootthikanokkhan J. , Tongrubbai B. 
Published: October 2002

AbstractMorphology and physical properties of natural–acrylic rubber blends were investigated as a function of blend compositions and mixing methods. In the first method, the masticated natural rubber was cross‐blended with the acrylic rubber for 15 min, followed by a sequential addition of vulcanizing chemicals (ZnO, stearic acid, MBT, sodium stearate, and sulfur), and the mixing was terminated within 15 min. In the second method, the masticated natural rubber was premixed with its relevant vulcanizing chemicals (excepting the sulfur) for 7 min, followed by blending it with the acrylic rubber and sodium stearate for 20 min. Finally, the sulfur was added and the mixing was continued for further 3 min before termination. The resulting blends were vulcanized to their optimum cure time in a compression mold. The rubber sheet was cut into a dumbbell‐shaped specimen, and tensile properties were determined at a cross‐head speed of 500 mm/min. The morphology of the blends was examined with scanning electron microscopy (SEM). The SEM specimen was prepared by cryo‐fracturing, followed by staining with OsO4. It was found that all of the rubber blends were immiscible, as shown by there being two separated phases in the SEM micrographs. The result was in a good agreement with that from a thermal analysis (using a differential scanning calorimeter), which showed two glass transition temperatures. Morphology of the rubber blends changed from a cocontinuous morphology to a dispersed particle morphology as the natural rubber content was increased from 20% to 80% by weight. Increasing the natural rubber content enhanced tensile properties of the rubber blends at the expense of their oil and heat resistance. Most of these properties being examined seemed to be unaffected by the mixing method, with the exception of the retention of tensile strain after aging. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1532–1539, 2002
Mechanical properties and fracture behavior of blends of acrylonitrile–butadiene–styrene copolymer and crystalline engineering plastics
Authors: Liu Xiaodong , Boldizar Antal , Rigdahl Mikael , Bertilsson Hand 
Published: October 2002

AbstractThe aim of this investigation was to evaluate the possibility of mechanically recycling blends of ABS with minor amounts of semicrystalline engineering plastics, such as polyamide, poly(ethylene terephthalate), and poly(butylene terephthalate). Compatibilizers and a core–shell impact modifier were incorporated into the blends in order to improve the mechanical properties. The toughness values, measured by the J‐integral method, and the Charpy impact strength did not always exhibit consistent results, due to the significant difference in deformation rate and in fracture mechanism. The formation of co‐continuous structures in the blends were noted and discussed. The fibrillation in the fracture surface contributed to the toughness as measured by the J‐integral method. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2435–2448, 2002
Mechanical property and morphology comparison between the two blends poly(propylene)/ethylene‐propylene‐diene monomer elastomer and poly(propylene)/maleic anhydride‐g‐ethylene‐propylene‐diene monomer
Authors: Zhao Ruofei , Dai Gance 
Published: October 2002

AbstractThe comparison of the mechanical properties between poly(propylene)/ethylene‐propylene‐diene monomer elastomer (PP/EPDM) and poly(propylene)/maleic anhydride‐g‐ethylene‐propylene‐diene monomer [PP/MEPDM (MAH‐g‐EPDM)] showed that the latter blend has noticeably higher Izod impact strength but lower Young's modulus than the former one. Phase morphology of the two blends was examined by dynamic mechanical thermal analysis, indicating that the miscibility of PP/MEPDM was inferior to PP/EPDM. The poor miscibility of PP/MEPDM degrades the nucleation effectiveness of the elastomer on PP. The observations of the impact fracture mode of the two blends and the dispersion state of the elastomers, determined by scanning electron microscopy, showed that PP/EPDM fractured in a brittle mode, whereas PP/MEPDM in a ductile one, and that a finer dispersion of MEPDM was found in the blend PP/MEPDM. These observations indicate that the difference in the dispersion state of elastomer between PP/EPDM and PP/MEPDM results in different fracture modes, and thereby affects the toughness of the two blends. The finer dispersion of MEPDM in the blend of PP/MEPDM was attributed to the part cross‐linking of MEPDM resulting from the grafting reaction of EPDM with maleic anhydride (MAH) in the presence of dicumyl peroxide (DCP). © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2486–2491, 2002
Effect of nucleating agents on the crystallization of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Authors: Liu W. J. , Yang H. L. , Wang Z. , Dong L. S. , Liu J. J. 
Published: October 2002

AbstractThe effect of nucleating agents on the crystallization behavior of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) was studied. A differential scanning calorimeter was used to monitor the energy of the crystallization process from the melt and melting behavior. During the crystallization process from the melt, nucleating agent led to an increase in crystallization temperature (Tc) of PHBV compared with that for plain PHBV (without nucleating agent). The melting temperature of PHBV changed little with addition of nucleating agent. However, the areas of two melting peaks changed considerably with added nucleating agent. During isothermal crystallization, dependence of the relative degree of crystallization on time was described by the Avrami equation. The addition of nucleating agent caused an increase in the overall crystallization rate of PHBV, but did not influence the mechanism of nucleation and growth of the PHB crystals. The equilibrium melting temperature of PHBV was determined as 187°C. Analysis of kinetic data according to nucleation theories showed that the increase in crystallization rate of PHBV in the composite is due to the decrease in surface energy of the extremity surface. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2145–2152, 2002
Preparation, characterization, and mechanical properties of some microcellular polysulfone foams
Authors: Sun Hongliu , Mark James E. 
Published: October 2002

AbstractSeveral polymers were evaluated as candidates for the production of high‐performance microcellular closed‐cell foams. The polymers involved were a polysulfone, a polyethersulfone, a polyphenylsulfone, a polyetherimide, and a poly(ether ketone ketone), and their suitability was gauged by measuring rates at which they could be impregnated with carbon dioxide under pressure at room temperature. This step is essential to the subsequent step of heating the impregnated samples at various temperatures to create foamed structures. The present study focused primarily on the use of the polysulfone in this regard. Microcellular foams of this polymer were found to have average cell sizes in the range 1–10 μm and cell densities on the order of 1010–1014cells/cm3. The microstructures of these foamed samples were controlled through careful choices of the foaming temperature and the foaming speed to produce a wide range of foam densities. Since these materials were prepared for possible use as structural materials, tensile tests were conducted to investigate the dependence of some of their mechanical properties on the foam densities (relative to those of the unfoamed polymer). The results indicated that the tensile moduli of these polysulfone foams increased with the square of their relative densities, and the tensile strengths were proportional to these densities. Both of these experimental findings are in agreement with theory. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1692–1701, 2002
Studies on dielectric relaxation and ac conductivity of cellulose acetate hydrogen phthalate–poly (vinyl pyrrolidone) blend
Authors: Rao Vijayalakshmi , Ashokan P. V. , Amar J. V. 
Published: October 2002

AbstractThe dielectric constant, dielectric loss, and ac conductivity of polyblends of cellulose acetate hydrogen phthalate (CAP) and poly (vinyl pyrrolidone) (PVP) of different compositions were measured in the temperature range of 300–430 K and in the frequency range of 50 Hz–100 kHz. In the blends, the dielectric constant as well as the dielectric loss as a function of the temperature display a single peak corresponding to the glass transition temperature (Tg) in the region between the Tg values of the pure polymers. The Tg values observed agree well with those values obtained from DSC. Dielectric studies show that CAP forms a miscible blend with PVP. Ac conductivity values were calculated from the dielectric data and the conduction mechanism is discussed. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1702–1708, 2002
Synthesis and characterization of electrically conducting copolymer of aniline and o‐bromoaniline using methane sulfonic acid as dopant
Authors: Roy Bidhan C. , Gupta Maya Dutta , Bhowmik Leena , Ray Jayanta K. 
Published: October 2002

AbstractPolyaniline (PAN), poly(o‐bromoaniline) (POBA), and poly(aniline‐co‐o‐bromoaniline) (PABA) were synthesized by oxidative coupling. These polymers are protonated by 10–20% methane sulfonic acid (MSA) and 1M HCl. The new polymer bases have greater solubility than that of PAN in common polar organic solvents; PAN–MSA was observed to be the most thermally stable of these polymers. POBA is associated with residual quinoid diimine units as illustrated in the IR and UV‐vis spectra, after reduction with hydrazine dihydrochloride. Both the doping agents cause a downward shift of the quinoid absorption in the IR spectra. MSA‐ and HCl‐doped PAN and PABA polymers exhibit a coil‐like conformation in DMSO, whereas only MSA‐doped PAN and PABA show an “expanded coil‐like” conformation in m‐cresol with a “free carrier tail” above 800 nm in their electronic spectra. XPS spectra indicated the presence of covalent bromine in the POBA and PABA polymers. Bromine retention was greater in the homopolymer as evidenced by the IR studies after aging at 350°C. Compared to HCl, MSA is found to be a more effective dopant, enhancing the conductivity of the copolymers by 102–103 times in magnitude. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2662–2669, 2002