bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of interleukin‐1β single nucleotide polymorphisms and depressive symptoms in individuals with chronic viral hepatitis
Authors: Huang Hsin‐Yi , Yu Rwei‐Ling , Tsai Wei‐Fang , Chuang Wan‐Long , Huang Jee‐Fu , Dai Chia‐Yen , Tan Chun‐Hsiang 
Published: November 2023

AbstractElevated levels of interleukin 1β (IL‐1β) have been identified in patients with chronic viral hepatitis and have been associated with depressive symptoms. Given the high prevalence of depression in this patient population, this study sought to explore the potential influence of IL‐1β genetic variations on the severity of depressive symptoms. In a cohort of 181 Taiwanese patients with chronic viral hepatitis, we investigated the impact of five common IL‐1β single nucleotide polymorphisms (SNPs), including rs16944, rs1143627, rs1143630, rs1143643, and rs3136558, on depressive symptoms using the Beck's Depression Inventory‐II. Additionally, we analyzed the primary domains of IL‐1β‐related depressive symptoms according to Beck's six symptom categories of depression. Our analysis revealed significant associations between depressive symptoms and three intronic IL‐1β SNPs. After controlling for age, sex, marital status, and education level, patients with the rs1143630 GG, rs1143643 CC, and rs3136558 AA genotypes demonstrated higher severity of depressive symptoms in the domains of indecision (p = 0.004), agitation (p = 0.001), and feelings of punishment (p = 0.005), respectively, compared to rs1143630 GA+AA, rs1143643 CT, and rs3136558 AG+GG genotypes. According to Beck's categorization, these symptoms can be classified into three dimensions: disturbances in emotion regulation, energy, and cognition. Our findings demonstrate the association between IL‐1β polymorphisms and depressive symptoms and suggest a potential underlying mechanism for specific depressive symptoms within the chronic viral hepatitis population. These insights could improve our understanding and treatment of depressive symptoms in individuals with viral hepatitis.
Does business strategy of the state‐owned enterprise affect the participation of non‐state‐owned capital?: Empirical evidence from China
Authors: Zhao Xiaoyang , Yu Su 
Published: November 2023

AbstractHow to improve the operational efficiency of state‐owned enterprises (SOEs) is an important issue facing emerging economies or developing countries. This study investigates whether and how business strategies of SOEs affect the participation of non‐state‐owned capital using Chinese enterprises from 2008 to 2019. The study finds that there is a positive effect of aggressive corporate strategy on the motivation of private capital to participate in mixed ownership reform. Mechanism tests have shown that prospector strategy increases the reform motivation of SOEs by boosting investment in technological and knowledge capital and financing demand and also increase the willingness of private enterprises to participate by increasing SOEs' value. Further research is found that when the SOEs are more politically connected, in commercial competition industries, and located in regions with cleaner governments, the effect of business strategy on the participation of non‐state‐owned capital is more significant. This study not only enriches relevant research on the factors influencing mixed ownership reform at the micro level but also provides valuable experience and reference for economic reforms in emerging markets and developing countries.
6aH‐Benzo[α]fluorene: NMR evidence of the unexpected product of the reaction of butyryl chloride with 1,2‐diphenylacetylene
Authors: Zinchenko Sergey V. , Kobelevskaya Valentina A. , Popov Alexander V. 
Published: November 2023

AbstractThe reaction of butyryl chloride with ethynylbenzene in the presence of AlCl3 afforded a mixture of the Z/E‐isomers of 1‐chloro‐2‐phenylhex‐1‐en‐3‐one. 1,2‐Diphenylethyne under these conditions gave a novel polycarbocycle core, 6aH‐benzo[a]fluorene. The chemical structure of 11‐chloro‐5,6‐diphenyl‐6a‐propyl‐6aH‐benzo[a]fluorene was established by means of IE‐MS, 1H, 13C NMR, COSY, HSQC, HMBC, and 2D INADEQUATE technique.
Benefits of Immunoglobulin (Ig) Replacement Therapy for Primary and Secondary Immunodeficiency in Chronic Rhinosinusitis
Authors: Garvey Emily A. , Arielle Best Keisha , Naimi Bita , Duffy Alexander , Hannikainen Paavali , Kahn Chase , Farquhar Douglas , Rosen Marc , Rabinowitz Mindy , Fung Shirley , Toskala Elina , Nyquist Gurston 
Published: November 2023

AbstractThis is the first study to examine chronic rhinosinusitis (CRS) outcomes after starting immunoglobulin (Ig) replacement therapy for patients with primary (PID) and secondary immunodeficiency (SID). This is a retrospective review of patients diagnosed with CRS from 2018 to 2022 prior to initiating Ig therapy for the treatment of PID or SID. Outcomes included medication use and Sinonasal Outcome Test (SNOT‐22) scores. Ten patients met the inclusion criteria. PID and SID patients had a decrease in antibiotics (PID: 9.40 to 3.20, P = .05, SID: 8.20 to 2.00, P = .04) and steroids (PID: (5.40 to 0.60; P = .06; SID: 2.20 to 0.20, P = .047) prescribed in the year after Ig compared to the year prior. Patients with SID had a decrease in mean SNOT‐22 scores by 12 months after Ig (47.50 to 20.50, P = 0.03). Patients receiving Ig for PID and SID showed decreased medication use and SID patients experienced subjective improvement in CRS symptoms in year‐over‐year comparison.
Comparing Feedback Techniques in Bilobe Flap Simulation Using 3D‐Printed Facial Models
Authors: Shay Aryan , Zaniletti Isabella , Coffman Hannah , Mehta Sagar , Richter Gresham 
Published: November 2023

AbstractObjectiveTo compare live versus delayed feedback on trainee performance of bilobe flaps using 3‐dimensional (3D)‐printed facial simulators and determine whether these effects are sustained on repeat performance.Study DesignCohort study.SettingUniversity of Arkansas for Medical Sciences.Methods3D‐printed facial models with a nasal ala defect were provided to 18 subjects. Subjects were stratified and randomized based on their training level into 1 of 3 groups corresponding to live feedback (Group 1), delayed feedback (Group 2), and no feedback (Group 3). Subjects performed a bilobe flap following a structured lecture. Four weeks later, subjects independently repeated the exercise on the contralateral ala. Likert surveys were used to assess subjective parameters. Objective grading was performed by a plastic surgeon, which included a point system and score for the overall appearance.ResultsFollowing exercise 1, Group 1 reported a significant improvement in knowledge (P < .001), which was sustained after exercise 2 (P < .001); Group 2 reported a significant improvement after exercise 1 (P = .03) but was not sustained (P = .435). After the second exercise, Group 1 and Group 2 improved their confidence in bilobed repair (P = .001 and P = .003, respectively), but this was greater for Group 1. Group 1 showed a significant improvement in their design time following exercise 2 (P = .007). There were no significant differences between groups on total time for repair, total score, and appearance.Conclusion3D‐printed models are valuable in teaching the bilobe flap for nasal defects, with live feedback providing the greatest level of improvement in self‐reported knowledge and confidence.
Preparation of modified zeolite/chitosan composites and study on the adsorption performance of Pb2+
Authors: Du Jingyu , Sun Junzhuo , Zhang Daohai 
Published: November 2023

AbstractAs one of the most common pollutants in wastewater, heavy metals seriously threaten human health and survival, and among the current removal methods, the adsorption method has attracted the most attention because of its simple and safe operation. Zeolite is a substance with a unique spatial structure, cheap cost, and environmental friendliness. Zeolite is a substance with a unique spatial structure, cheap cost, and environmental friendliness. Due to its size and high surface area‐to‐volume ratio, zeolite exhibits excellent adsorption and ion exchange properties and is a promising adsorbent. In this paper, the modified zeolite chitosan composite film was prepared by solution method by dissolving chitosan in acetic acid solution as the solvent, and the effects of zeolite content, modifier type, initial pH, pore‐making agent, adsorption time, adsorption temperature, initial concentration, and feeding amount were studied. The optimal conditions for Pb2+ adsorption were 40% modified zeolite content, 293 K in 100 mg/L solution, a feeding amount of 1 g/L, pH = 5.5, and a removal rate of 96.6% in 24 h. The isotherm is consistent with the Langmuir adsorption model, which is manifested as single‐molecule chemical adsorption, and the highest saturated adsorption capacity is 139.6 mg/g. After five cycles, it still has a greater than 90% initial adsorption effect.Highlights
Chitosan‐modified zeolite composite membranes are inexpensive.
After adsorption, the sorbent is easy to recover.
Utilization of rehabilitation services in violent versus nonviolent traumatic spinal cord injury
Authors: Barnett Heather M. , Wilson Josh M. , Kunapaisal Thitikan , Nehra Deepika , Vavilala Monica S. , Hoffman Jeanne M. , Crane Deborah A. 
Published: November 2023

AbstractBackgroundViolence is the third leading cause of spinal cord injury (SCI) in the United States, and people with violence‐related SCI have worse long‐term outcomes compared to other traumatic SCI etiologies. Little is known, however, about the underlying reasons for these differences. Access to and utilization of rehabilitation services may differ in this population, but their outpatient care has not been previously investigated.ObjectiveTo evaluate differences in utilization patterns of outpatient rehabilitation services between people with violence‐related SCI and other traumatic SCI etiologies.DesignRetrospective cohort study.SettingAcademic tertiary care hospital system.PatientsA total of 41 patients with violence‐related SCI residing in King County at the time of injury who completed inpatient rehabilitation (IPR) in our institution were identified from the hospital trauma registry and matched with 41 control patients with nonviolent traumatic SCI.InterventionsNot applicable.Main Outcome Measure(s)The number of appointments attended, canceled, and missed during the first year after discharge from IPR were obtained by chart review for physical medicine & rehabilitation (PM&R) physicians and therapy services.ResultsPeople with violence‐related SCI had decreased follow‐up with outpatient rehabilitation services after IPR discharge compared to non‐violent traumatic SCI, including PM&R (2.50 ± 2.44 vs. 3.76 ± 2.21 visits, β = −1.28, p = .017), physical therapy (8.91 ± 11.02 vs. 17.57 ± 15.26, β = −9.79, p = .009), occupational therapy (4.28 ± 7.90 vs. 10.04 ± 14.42, β = −6.18, p = .033), and recreational therapy (0.293 ± 0.955 vs. 1.37 ± 2.86, β = −1.07, p = .035). The rate of missed appointments was also higher among people with violence‐related SCI compared to controls for PM&R (25.2% ± 28.5% vs. 9.9% ± 16.5%, β = 14.6%, p = .014) and physical therapy (26.0% ± 32.0% vs 4.2% ± 13.2%, β = 22.1%, p = .009).ConclusionsIndividuals with violence‐related SCI had fewer follow‐up appointments with PM&R physicians and other allied health professionals and were more likely to miss scheduled appointments compared to other traumatic SCI etiologies. Decreased outpatient follow‐up may affect long‐term outcomes for people with violence‐related SCI.
Ewing's sarcoma in a young man mimicking lateral elbow pain: A case report with 2 years follow‐up
Authors: Zanconato Laura , Rossettini Giacomo , Mourad Firas , Cotrozzi Maurizio , Carità Enrico , Di Filippo Luigi , Turolla Andrea , Smania Nicola , Picelli Alessandro , Valè Nicola , Maselli Filippo 
Published: November 2023

AbstractBackground and PurposeLateral elbow pain represents a common musculoskeletal disorder, mostly non‐specific and benign. In rare cases, it can be the first symptom of a severe disease such as Ewing's sarcoma (ES). ES is the second most common primary malignant bone tumor in the young population, with a high probability of an unfavourable prognosis.Case PresentationThis case report presents the history of a young man presenting to the physical therapist with a diagnosis of “epicondylitis” in the right elbow, which was later revealed to be an aggressive ES of the ulna. Findings raising clinical doubts were (a) constant pain even at night and not dependent on load, (b) significant loss of function, (c) patient's young age, and (d) a palpable mass in the elbow.ResultsAfter diagnosis, the patient received medical (chemotherapy, radiotherapy and surgery) and a rehabilitation program. After treatment, the patient improved elbow function, decreased disability and returned to social participation, maintaining positive outcomes at the 2‐year follow‐up.DiscussionIn summary, this case report emphasizes the importance of differential diagnosis and screening for referral of red flags in physical therapy. Moreover, it describes the rehabilitation of a patient with ES, enriching the scientific literature in the field.
Widespread amyloid aggregates formation by Zika virus proteins and peptides
Authors: Giri Rajanish , Bhardwaj Taniya , Kapuganti Shivani K. , Saumya Kumar Udit , Sharma Nitin , Bhardwaj Aparna , Joshi Richa , Verma Deepanshu , Gadhave Kundlik 
Published: November 2023

AbstractViral pathogenesis typically involves numerous molecular mechanisms. Protein aggregation is a relatively unknown characteristic of viruses, despite the fact that viral proteins have been shown to form terminally misfolded forms. Zika virus (ZIKV) is a neurotropic one with the potential to cause neurodegeneration. Its protein amyloid aggregation may link the neurodegenerative component to the pathogenicity associated with the viral infection. Therefore, we investigated protein aggregation in the ZIKV proteome as a putative pathogenic route and one of the alternate pathways. We discovered that it contains numerous anticipated aggregation‐prone regions in this investigation. To validate our prediction, we used a combination of supporting experimental techniques routinely used for morphological characterization and study of amyloid aggregates. Several ZIKV proteins and peptides, including the full‐length envelope protein, its domain III (EDIII) and fusion peptide, Pr N‐terminal peptide, NS1 β‐roll peptide, membrane‐embedded signal peptide 2K, and cytosolic region of NS4B protein, were shown to be highly aggregating in our study. Because our findings show that viral proteins can form amyloids in vitro, we need to do a thorough functional study of these anticipated APRs to understand better the role of amyloids in the pathophysiology of ZIKV infection.
Bacillus velezensis WB induces systemic resistance in watermelon against Fusarium wilt
Authors: Chen Zhongnan , Wang Zhigang , Xu Weihui 
Published: November 2023

AbstractBACKGROUNDOur previous findings indicated that Bacillus velezensis WB could control Fusarium wilt by changing the structure of the microbial community in the watermelon rhizosphere. However, there are few studies on its mechanism in the pathogen resistance of watermelon. Therefore, in this study, we determined the mechanism of B. velezensis WB‐induced systemic resistance in watermelon against Fusarium wilt through glasshouse pot experiments.RESULTSThe results showed that B. velezensis WB significantly reduced the incidence and disease index of Fusarium wilt in watermelon. B. velezensis WB can enhance the basal immunity of watermelon plants by: increasing the activity of phenylalanine ammonia‐lyase (PAL), peroxidase (POD), superoxide dismutase (SOD) and β‐1,3‐glucanase; accumulating lignin, salicylic acid (SA) and jasmonic acid (JA); reducing malondialdehyde (MDA) concentrations; and inducing callus deposition in watermelon plant cells. RNA‐seq analysis showed that 846 watermelon genes were upregulated and 612 watermelon genes were downregulated in the WF treatment. This process led to the activation of watermelon genes associated with auxin, gibberellin, SA, ethylene and JA, and the expression of genes in the phenylalanine biosynthetic pathway was upregulated. In addition, transcription factors involved in plant resistance to pathogens, such as MYB, NAC and WRKY, were induced. Gene correlation analysis showed that Cla97C10G195840 and Cla97C02G049930 in the phenylalanine biosynthetic pathway, and Cla97C02G041360 and Cla97C10G197290 in the plant hormone signal transduction pathway showed strong correlations with other genes.CONCLUSIONOur results indicated that B. velezensis WB is capable of inducing systemic resistance in watermelon against Fusarium wilt. © 2023 Society of Chemical Industry.
Design and aircraft‐in‐the‐loop validation of structured‐H∞ self‐scheduled fault‐tolerant controllers
Authors: Waitman S. , Marcos A. , Sato M. 
Published: November 2023

AbstractThis paper presents the design of a self‐scheduled fault‐tolerant controller for the lateral/directional motion of MuPAL‐ research aircraft using a polynomial‐scheduled structured H control. The controller is designed to be tolerant against loss‐of‐efficiency faults in the aileron and rudder, but based on industrial best practices it is scheduled with respect to an overall fault level instead of with respect to the individual faults. The performance and robustness of the resulting controller is verified first using frequency and time domain analysis, and subsequently it is validated in the Aircraft‐In‐the‐Loop configuration of MuPAL‐, where the real aircraft is operated in research Fly‐By‐Wire mode by the pilot on‐ground while coupled to an emulation computer that simulates the aircraft flying motion. The results show good behavior of the controlled aircraft across the defined fault scenarios.
Prominent examples of flip processes
Authors: Araújo Pedro , Hladký Jan , Hng Eng Keat , Šileikis Matas 
Published: November 2023

AbstractFlip processes, introduced in [Garbe, Hladký, Šileikis, Skerman: From flip processes to dynamical systems on graphons], are a class of random graph processes defined using a rule which is just a function from all labelled graphs of a fixed order into itself. The process starts with an arbitrary given ‐vertex graph . In each step, the graph is obtained by sampling random vertices of and replacing the induced graph by .Using the formalism of dynamical systems on graphons associated to each such flip process from ibid. we study several specific flip processes, including the triangle removal flip process and its generalizations, ‘extremist flip processes’ (in which is either a clique or an independent set, depending on whether has less or more than half of all potential edges), and ‘ignorant flip processes’ in which the output does not depend on .
Extended reality (XR)—A magic box of digitalization in driving sustainable development of the construction industry: A critical review
Authors: Li Hongyang , Fang Shuying , Chen Long , Menadue Vanessa , Martin Skitmore 
Published: November 2023

AbstractAgainst a background of global resource shortage and climate change, there is an urgency for the construction industry to aim towards sustainable development. With the rapid development of information technology, the emergence of extended reality (XR) has provided new ideas and options for sustainable construction (SC). Such technologies are applied in research and practice of the whole construction lifecycle, which can well meet the requirements of SC. This paper presents a critical review of XR applications in SC, aiming to systematically summarize the specific uses and advantages of virtual reality (VR), augmented reality (AR), and mixed reality (MR) technologies. This study also examines the gap in research into the imbalance between the use of technology and the construction stages involved. Most XR applications focus on the preconstruction stage, while visualization and interactivity are the main features for further application. Through qualitative analyses, different applications of XR are introduced in stages throughout the entire lifecycle of building projects. In addition, the current challenges and limitations are presented, and several suggestions are proposed to facilitate further advancements in SC research and practice in the near future. This review provides valuable information to help stakeholders understand the advances in XR research and benefit future exploration and practice in the field.
Thermally Reduced Graphene Oxide Membranes From Local Kazakhstan Graphite “Ognevsky”
Authors: Kuanyshbekov Tilek , Guseinov Nazim , Tolepov Zhandos , Kurbanova Bayan , Tulegenova Malika , Akatan Kydyrmolla , Kantay Nurgamit , Zhasasynov Elzhas 
Published: November 2023

AbstractThe properties of pure graphene and reduced graphene oxide (RGO) are close, so thermal annealing is a simple, safe and more cost‐effective alternative, in comparison to other methods to produce graphene oxide (GO) on a significant scale. In this work, for the first time, for the production of GO and its membrane with subsequent thermal reduction, local Kazakhstan “Ognevsky” graphite was used as the initial raw material. The GO membrane was obtained by vacuum filtration and subjected to thermal annealing at various temperatures in a hydrogen atmosphere. It was noticed, that after the thermal recovery of GO membranes, their physical and chemical properties changed. This changes show the possibility of using GO new membranes as a potential material for sensitive elements, such kind of gas and humidity sensors. In this regard, GO and RGO membranes were studied by: SEM, EDX, FTIR, XRD, TGA and Raman spectroscopy. This work demonstrates a new and efficient strategy for manufacturing high performance RGO membranes from local raw materials.
Design, Synthesis, Anticancer Screening and Molecular Modelling Studies of Novel Thiazoles
Authors: Abu Nuwar Mohammad , Jaradat Da'san M. M. , Chandrasekaran Balakumar , Natsheh Iyad , Rasras Anas J. , Alzubi Mohammad S. H. , Karpoormath Rajshekhar , Khalili Fawwaz , Hamadneh Lama , Dahadha Adnan A. , Arafat Tawfiq 
Published: November 2023

AbstractA library of novel benzamide‐thiazolyl‐chalcone compounds was synthesized via Claisen‐Schmidt reaction and spectroscopically characterized using FT‐IR, 1H‐NMR, 13C‐NMR, LC–MS, and HR‐MS. The synthesized compounds were biologically evaluated using in vitro MTT assay against different cancer cell lines (MCF‐7, MDA‐AMB‐231, Caco‐2, A549, and H1299). Amongst all compounds screened, (E)‐N‐(5‐(3‐(4‐hydroxyphenyl)‐3‐oxoprop‐1‐en‐1‐yl)thiazol‐2‐yl)benzamide and (E)‐N‐(5‐(3‐(4‐methoxyphenyl)‐3‐oxoprop‐1‐en‐1‐yl)thiazol‐2‐yl)benzamide showed potent anti‐proliferation against breast (MCF‐7) and colon cancer cell lines reaching 88.56 % and 84.36 % with IC50 values of 44.00 μM and 58.88 μM, respectively. All synthesized compounds exhibited no significant cytotoxicity to normal cells. Structure‐activity relationship studies demonstrated the effect of electron‐donating and electron‐withdrawing groups on the anticancer activity of the molecules under investigation. This was also corroborated by theoretical DFT studies. Thus, these molecules may serve as potential lead candidates for further development of novel anticancer agents against breast and colon cancers.