bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of institution‐agnostic, EHR‐integrated regional clinical trial matching
Authors: Shriver Sharon P. , Arafat Waddah , Potteiger Caroline , Butler Dorothy L. , Beg Muhammad S. , Hullings Melanie , Semy Salim , Lister Zach , Khosama Leticia , Armstrong Susan , Hadley David , Pappa John , Fleury Mark E. 
Published: October 2023

AbstractBackgroundA lack of onsite clinical trials is the largest barrier to participation of cancer patients in trials. Development of an automated process for regional trial eligibility screening first requires identification of patient electronic health record data that allows effective trial screening, and evidence that searching for trials regionally has a positive impact compared with site‐specific searching.MethodsTo assess a screening framework that would support an automated regional search tool, a set of patient clinical variables was analyzed for prescreening clinical trials. The variables were used to assess regional compared with site‐specific screening throughout the United States.ResultsEight core variables from patient electronic health records were identified that yielded likely matches in a prescreen process. Assessment of the screening framework was performed using these variables to search for trials locally and regionally for an 84‐patient cohort. The likelihood that a trial returned in this prescreen was a provisional trial match was 45.7%. Expanding the search radius to 20 miles led to a net 91% increase in matches across cancers within the tested cohort. In a U.S. regional analysis, for sparsely populated areas, searching a 100‐mile radius using the prescreening framework was needed, whereas for urban areas a 20‐mile radius was sufficient.ConclusionA clinical trial screening framework was assessed that uses limited patient data to efficiently and effectively identify prescreen matches for clinical trials. This framework improves trial matching rates when searching regionally compared with locally, although the applicability of this framework may vary geographically depending on oncology practice density.Plain Language Summary

Clinical trials provide cancer patients the opportunity to participate in research and development of new drugs and treatment approaches. It can be difficult to find available clinical trials for which a patient is eligible.
This article describes an approach to clinical trial matching using limited patient data to search for trials regionally, beyond just the patient’s local care site.
Feasibility testing shows that this process can lead to a net 91% increase in the number of potential clinical trial matches available within 20 miles of a patient.
Based on these findings, a software tool based on this model is being developed that will automatically send limited, deidentified information from patient medical records to services that can identify possible clinical trials within a given region.
Consensus recommendations for improving the cancer clinical trial matching environment
Authors: Fleury Mark E. 
Published: October 2023

AbstractEnrollment in cancer clinical trials cannot occur without first successfully identifying trials for which patients are a match based on their clinical characteristics. A lack of onsite matching trials has been identified as the single largest barrier preventing patients from participating in clinical trials. The site‐agnostic cancer clinical trial matching environment is a mix of public and private tools and infrastructure that are not designed to work together to facilitate trial matching in an efficient manner. To identify policy and infrastructure solutions that could enable more effective and more frequent use of third‐party site‐agnostic matching, the American Cancer Society Cancer Action Network held a summit to examine challenges and propose consensus recommendations that could address those challenges. At this 2019 summit, stakeholders in this field examined these barriers and challenges and made a number of policy and infrastructure recommendations to improve the ability of this environment to work in a more coordinated and efficient manner.
Connectivity and molecular profiles of Foxp2‐ and Dbx1‐lineage neurons in the accessory olfactory bulb and medial amygdala
Authors: Prakash Nandkishore , Matos Heidi Y. , Sebaoui Sonia , Tsai Luke , Tran Tuyen , Aromolaran Adejimi , Atrachji Isabella , Campbell Nya , Goodrich Meredith , Hernandez‐Pineda David , Herrero Maria Jesus , Hirata Tsutomu , Lischinsky Julieta , Martinez Wendolin , Torii Shisui , Yamashita Satoshi , Hosseini Hassan , Sokolowski Katie , Esumi Shigeyuki , Kawasawa Yuka Imamura , Hashimoto‐Torii Kazue , Jones Kevin S. , Corbin Joshua G. 
Published: October 2023

AbstractIn terrestrial vertebrates, the olfactory system is divided into main (MOS) and accessory (AOS) components that process both volatile and nonvolatile cues to generate appropriate behavioral responses. While much is known regarding the molecular diversity of neurons that comprise the MOS, less is known about the AOS. Here, focusing on the vomeronasal organ (VNO), the accessory olfactory bulb (AOB), and the medial amygdala (MeA), we reveal that populations of neurons in the AOS can be molecularly subdivided based on their ongoing or prior expression of the transcription factors Foxp2 or Dbx1, which delineate separate populations of GABAergic output neurons in the MeA. We show that a majority of AOB neurons that project directly to the MeA are of the Foxp2 lineage. Using single‐neuron patch‐clamp electrophysiology, we further reveal that in addition to sex‐specific differences across lineage, the frequency of excitatory input to MeA Dbx1‐ and Foxp2‐lineage neurons differs between sexes. Together, this work uncovers a novel molecular diversity of AOS neurons, and lineage and sex differences in patterns of connectivity.
Unveiling the electron configuration‐dependent oxygen evolution activity of 2D porous Sr‐substituted LaFeO3 perovskite through microwave shock
Authors: Fang Guangyu , Liu Kaisi , Fan Miao , Xian Jinglin , Wu Zhiao , Wei Liyun , Tian Haoran , Jiang Huiyu , Xu Weilin , Jin Huanyu , Wan Jun 
Published: October 2023

AbstractDeveloping an efficient and stable oxygen evolution reaction (OER) catalyst is beneficial in various energy conversion and storage applications for achieving the “Carbon Neutrality” goal. Among the iron‐based perovskite oxides (AFeO3), LaFeO3 stands out as a preferred catalyst for electrocatalytic OER due to its exceptional selectivity in oxygen bonding at the A‐site. The introduction of A‐site substitution and controlled morphological engineering in perovskite structures has proven effective in enhancing the electrical conductivity and intrinsic catalytic activity. Nevertheless, the conventional A‐site substitution approach often involves prolonged high‐temperature calcination, leading to the agglomeration of nanostructures, particularly in two‐dimensional (2D) porous configurations. Herein, we introduce a novel method for synthesizing 2D porous LaFeO3 perovskite with A‐site Sr substitution using microwave shock. This microwave technique capitalizes on the benefits of transient heating and cooling, enabling simultaneous construction of 2D porous morphology and precise regulation of Sr substitution in one step. By conducting theoretical simulations of the electron configuration and analysis of crystal structure, we unveil the impact of Sr substitution on the OER activity of 2D porous LaFeO3. The synthesized La0.2Sr0.8FeO3 (LSFO‐8) catalyst exhibits an exceptional overpotential of 339 mV at 10 mA cm−2 and a small Tafel slope of 56.84 mV dec−1 in alkaline electrolyte. This investigation provides a fresh perspective for the design and engineering of electronic configuration in highly active 2D perovskite materials.
Crosstalk between m6A modification and alternative splicing during cancer progression
Authors: Zhu Zhi‐Man , Huo Fu‐Chun , Zhang Jian , Shan Hong‐Jian , Pei Dong‐Sheng 
Published: October 2023

AbstractBackgroundN6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins. This modification significantly influences carious facets of RNA metabolism and plays a pivotal role in cellular and physiological processes.Main bodyPre‐mRNA alternative splicing, a process that generates multiple splice isoforms from multi‐exon genes, contributes significantly to the protein diversity in mammals. Moreover, the presence of crosstalk between m6A modification and alternative splicing, with m6A modifications on pre‐mRNAs exerting regulatory control, has been established. The m6A modification modulates alternative splicing patterns by recruiting specific RNA‐binding proteins (RBPs) that regulate alternative splicing or by directly influencing the interaction between RBPs and their target RNAs. Conversely, alternative splicing can impact the deposition or recognition of m6A modification on mRNAs. The integration of m6A modifications has expanded the scope of therapeutic strategies for cancer treatment, while alternative splicing offers novel insights into the mechanistic role of m6A methylation in cancer initiation and progression.ConclusionThis review aims to highlight the biological functions of alternative splicing of m6A modification machinery and its implications in tumourigenesis. Furthermore, we discuss the clinical relevance of understanding m6A‐dependent alternative splicing in tumour therapies.
Activity‐aggression behavioural syndromes exist in males but not in females of the field cricket Teleogryllus emma
Authors: Han Chang S. , Lee Byeongho , Moon Jong‐yeol 
Published: October 2023

AbstractPrevious studies on sex differences in behaviour have largely focused on differences in average behaviours between sexes. However, males and females can diverge not only in average behaviours but also in the direction of behavioural correlations at the individual level (i.e. behavioural syndromes). Behavioural syndromes, with their potential to constrain the independent evolution of behaviours, may play a role in shaping sex‐specific responses to selection and contributing to the development of sex differences in behaviour. Despite the pivotal role of behavioural syndromes in the evolution of sexual dimorphism in behaviour, robust empirical evidence of sex differences in behavioural syndromes based on repeated measurements of behaviours is scarce. In this study, we conducted repeated measurements of activity and aggression in male and female field crickets Teleogryllus emma, providing evidence of sex differences in the existence of behavioural syndromes. Males exhibited a significantly positive behavioural syndrome between activity and aggression, whereas females, in contrast, did not show any aggressive behaviour, resulting in the absence of such a syndrome. The sex differences in the existence of the activity‐aggression behavioural syndromes in this species could be attributed to differences in selection. Selection favouring more active and aggressive males may have shaped a positive activity‐aggression behavioural syndrome in males, whereas the absence of selection favouring female aggression may have resulted in the absence of aggression and the related behavioural syndrome in females. However, given the plasticity of behaviour with changes in age or the environment, further research is needed to explore how sex differences in the existence of activity‐aggression behavioural syndromes change across contexts. Furthermore, understanding the genetic underpinning of sex differences in a behavioural syndrome would be pivotal to assess the role of behavioural syndromes in the evolution of sexual dimorphism in behaviours.
Leech‐derived iDNA complements traditional surveying methods, enhancing species detections for rapid biodiversity sampling in the tropics
Authors: Fahmy Mai , Andrianoely Dina , Wright Patricia C. , Hekkala Evon 
Published: October 2023

AbstractDeforestation, exploitation, and other drivers of biodiversity loss in Madagascar leave its highly endangered and predominantly endemic wildlife at risk of extinction. Decreasing biodiversity threatens to compromise ecosystem functions and vital services provided to people. New, economical, and diverse methods of biodiversity monitoring can help to establish reliable baseline and long‐term records of species richness. Metabarcoding with invertebrate‐derived DNA (iDNA) has emerged as a promising new biosurveillance tool. An unexpected wet forest fragment tucked in the dry cliffs of Madagascar's southcentral plateau, the Ivohibory Protected Area (IPA), hosts a unique mosaic of species diversity, featuring both dry and wet forest species. Recently elevated to protected status, the IPA has been surveyed for flora and fauna with a range of inventory methods over the course of three years and six expeditions (2016, 2017, & 2019). We collected 1451 leeches over 12 days from the IPA to supplement known species richness and to compare results against current records. With iDNA, we pooled tissues, isolated, and amplified bloodmeal DNA with five sets of primers. We detected 20 species of which four are species of frogs previously undetected and three of which are previously unknown to exist in this region. iDNA surveys have the capacity to provide complementary data to traditional surveying methods like camera traps, line transects, and bioacoustic methods.
Power factor control for inverters under high penetration of distributed generation
Authors: Yamada Yasuaki , Nanahara Toshiya , Yukita Kazuto 
Published: October 2023

AbstractThe paper proposes a method to select a power factor for an inverter of distributed power generation systems to keep appropriate voltage of a power system with the high penetration of inverter‐interfaced generation. The increase of inverter‐interfaced power sources, such as wind and photovoltaic power generation, arouses concerns on the voltage fluctuations in a power system. While constant power factor control of an inverter has been studied as a means to stabilize the voltage of a power system, there still remains room to improve the control. The proposed method in the paper selects the power factor based on the R/X ratio of the looking‐back impedance into the interconnected power system. By normalizing the related variables, a general formula is derived for the power factor, and the resultant relationship between the apparent power and voltage of an inverter becomes identical irrespective of the R/X ratio with the control. Sample studies show that, by operating an inverter with the power factor, voltage fluctuations are effectively suppressed even for a power system with the high penetration of inverter‐interfaced generation.
D‐dimer, C‐reactive protein and matrix metalloproteinase 9 for prediction of type A aortic dissection patient survival
Authors: Huang Minjie , Lian Yujie , Zeng Zhongyan , Li Jiahong 
Published: October 2023

AbstractAimsAcute type A aortic dissection (ATAAD) is a life‐threatening condition requiring prompt diagnosis and treatment. Surgery is an effective treatment for ATAAD, but the in‐hospital mortality rate in the 30 day perioperative period is still as high as 9–30%. It is critical to identify biological factors for preoperative assessment of post‐operative survival in patients with ATAAD.Methods and resultsThis is a retrospective study, investigating the association of combined measurements of d‐dimer, C‐reactive protein (CRP), and matrix metalloproteinase 9 (MMP9) for 1 year of survival in patients with ATAAD. Data from 247 patients who underwent surgery were analysed, including 89 patients who did not survive and 158 patients who survived within 1 year after surgery. Pearson's correlation analysis was carried out to determine the correlations between CRP in whole blood, d‐dimer in plasma, and CRP in whole blood. Receiver operating characteristic (ROC) analysis was used to analyse the value of preoperative whole blood CRP, plasma d‐dimer, and serum MMP9 concentration and the combined detection model in predicting death of patients with ATAAD. Deceased patients with ATAAD exhibited higher age, hypertension prevalence, systolic blood pressure, white blood cell count, whole blood CRP, plasma d‐dimer, and serum MMP9 levels compared with survivors. Preoperative CRP, d‐dimer, and MMP9 levels were significantly higher in patients with ATAAD compared with healthy controls. Positive correlations were observed between CRP and d‐dimer, CRP and MMP9, and d‐dimer and MMP9 in patients with ATAAD. ROC analysis showed that the combined detection model of CRP, d‐dimer, and MMP9 had the highest predictive value for 1 year of survival (area under the curve = 0.88).ConclusionsCombined measurement of CRP, d‐dimer, and MMP9 is associated with 1 year of survival in patients with ATAAD.
Exercise‐based cardiac rehabilitation for adults with heart failure – 2023 Cochrane systematic review and meta‐analysis
Authors: Molloy Cal D. , Long Linda , Mordi Ify R. , Bridges Charlene , Sagar Viral A. , Davies Edward J. , Coats Andrew J.S. , Dalal Hasnain , Rees Karen , Singh Sally J. , Taylor Rod S. 
Published: October 2023

AbstractAimsDespite strong evidence, access to exercise‐based cardiac rehabilitation (ExCR) remains low across global healthcare systems. We provide a contemporary update of the Cochrane review randomized trial evidence for ExCR for adults with heart failure (HF) and compare different delivery modes: centre‐based, home‐based (including digital support), and both (hybrid).Methods and resultsDatabases, bibliographies of previous systematic reviews and included trials, and trials registers were searched with no language restrictions. Randomized controlled trials, recruiting adults with HF, assigned to either ExCR or a no‐exercise control group, with follow‐up of ≥6 months were included. Two review authors independently screened titles for inclusion, extracted trial and patient characteristics, outcome data, and assessed risk of bias. Outcomes of mortality, hospitalization, and health‐related quality of life (HRQoL) were pooled across trials using meta‐analysis at short‐term (≤12 months) and long‐term follow‐up (>12 months) and stratified by delivery mode. Sixty trials (8728 participants) were included. In the short term, compared to control, ExCR did not impact all‐cause mortality (relative risk [RR] 0.93; 95% confidence interval [CI] 0.71–1.21), reduced all‐cause hospitalization (RR 0.69; 95% CI 0.56–0.86, number needed to treat: 13, 95% CI 9–22), and was associated with a clinically important improvement in HRQoL measured by the Minnesota Living with Heart Failure Questionnaire (MLWHF) overall score (mean difference: −7.39; 95% CI −10.30 to −4.47). Improvements in outcomes with ExCR was seen across centre, home (including digitally supported), and hybrid settings. A similar pattern of results was seen in the long term (mortality: RR 0.87, 95% CI 0.72–1.04; all‐cause hospitalization: RR 0.84, 95% CI 0.70–1.01, MLWHF: −9.59, 95% CI −17.48 to −1.50).ConclusionsTo improve global suboptimal levels of uptake for HF patients, global healthcare systems need to routinely recommend ExCR and offer a choice of mode of delivery, dependent on an individual patient's level of risk and complexity.
A spatially‐weighted AMH copula‐based dissimilarity measure for clustering variables: An application to urban thermal efficiency
Authors: Di Lascio F. Marta L. , Menapace Andrea , Pappadà Roberta 
Published: October 2023

AbstractInvestigating thermal energy demand is crucial for developing sustainable cities and the efficient use of renewable sources. Despite the advances made in this field, the analysis of energy data provided by smart grids is currently a demanding challenge due to their complex multivariate structure and high dimensionality. In this article, we propose a novel copula‐based dissimilarity measure suitable for analyzing district heating demand and introduce a procedure to apply it to high‐temporal resolution panel data. Inspired by the characteristics of the considered data, we explore the usefulness of the Ali‐Mikhail‐Haq copula in defining a new dissimilarity measure to cluster variables in the hierarchical framework. We show that our proposal is particularly sensitive to small dissimilarities based on tiny differences in the strength of the dependence between the involved random variables. Therefore, the measure we introduce is able to distinguish between objects with low dissimilarity better than standard rank‐based dissimilarity measures. Moreover, our proposal considers a weighted version of the copula‐based dissimilarity that embeds the spatial location of the involved objects. We investigate the proposed measure through Monte Carlo studies and compare it with an analogous dissimilarity measure based on Kendall's correlation. Finally, the application to real data concerning the Italian city Bozen‐Bolzano makes it possible to find clusters of buildings homogeneous with respect to their main characteristics, such as energy efficiency and heating surface. In turn, our findings may support the design, expansion, and management of district heating systems.
Experimental study of competitive heavy metals removal from multimetal solution using wheat bran as a biomaterial: Response surface methodology
Authors: Renu  , Agarwal Madhu , Singh Kailash 
Published: October 2023

AbstractBatch and continuous adsorption studies were performed for heavy metal removal from the ternary metal system using wheat bran as an adsorbent. An adsorbent pellet was prepared using clay and chitosan as a binder. For batch adsorption experiments, the Box–Behnken design of response surface methodology was used to optimize the process parameters for adsorption. In our mixed metal continuous study, cadmium (70%–80%) and chromium (74%–80%) had shown a synergistic effect on copper removal leading to an increase in breakthrough and exhaustion time. In a continuous study, a higher breakthrough time was obtained for copper at a bed height of 0.15 cm, a flow rate of 5 mL/min and an initial metal concentration of 100 mg/L. The modeling and simulation of the continuous adsorption process were performed. The breakthrough curve obtained from the model and from experiments was compared and high R2 values up to 0.99 and low chi‐square and MAPE values up to 0.018% and 0.037% indicate good fitting of model and experimental data. Regeneration studies results show that good desorption efficiency is obtained using regenerated wheat bran. The adsorbent was regenerated and reused up to five cycles and it showed good desorption efficiency of up to 95% for copper, 79% for cadmium and 80% for chromium.