bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrophilic Aromatic Substitution by the Fluorofullerene C60F18
Authors: Darwish Adam D. , Avent Anthony G. , Abdul‐Sada Ala'a K. , Gol'dt Ilya V. , Hitchcock Peter B. , Kuvytchko Igor V. , Taylor Roger 
Published: August 2004

AbstractThe FeCl3‐catalysed arylation of C60F18 gives tri‐substituted compounds C60F15Ar3, where Ar=phenyl, 4‐tolyl, 4‐methoxyphenyl, 4‐phenoxyphenyl, 4‐chlorophenyl, 3,4‐dichlorophenyl, 2‐biphylenyl and 2‐fluorenyl, together with some bis‐ and mono‐substituted product. Bis‐substitution was achieved with biphenylene and fluoranthene, and mono‐substitution with biphenylene (2‐position), pyrene (1‐position), and naphthalene (1‐ and 2‐positions); the tris‐phenyl and tris‐biphenylene derivatives are fluorescent. The 2‐naphthyl substituent freely rotates at 328 K, whereas rotation of the 1‐naphthyl substituent is prevented by interaction of the peri‐hydrogen atom with fluorine. The 1‐naphthyl derivative eliminates a molecule of HF during EI mass spectrometry, whilst the 2‐naphthyl derivative eliminates HF and all fluorenes to give a naphthaleno[60]fullerene. The reaction rate is relatively unaffected by electron supply in the aryl rings, but no product was obtained with benzotrifluoride which defines the lower reactivity limit. The low discrimination between aromatics makes it possible to isolate derivatives having different aryl groups attached to the cage. Reactions occur mainly when the reagent solutions (or solutions in 1,2‐dichlorobenzene) are evaporated to dryness. In most FeCl3‐catalysed reactions, unreacted C60F18 was recovered, more if the less effective SnCl4 was used as a catalyst; use of AlCl3 resulted in polyarylation and degradation of the C60F18. The structure of C60F17(1‐biphenylyl) was confirmed by single‐crystal X‐ray analysis. Reaction of C60F18 with perylene/FeCl3/o‐dichlorobenzene gave red fluorescent “tagliatelli”‐like threads (up to 1 cm long) of self‐assembled π‐stacked tetrachloroperylene arising from chlorination by FeCl3.
Structural and Electrochemical Studies of Novel Bis(μ‐methoxo)diiron complexes: Observation of FeIIIFeIV and FeIVFeIV States Resonating with Phenoxyl Radicals
Authors: Houjou Hirohiko , Kanesato Masatoshi , Hiratani Kazuhisa , Mandon Dominique 
Published: August 2004

AbstractNovel diiron complexes with an Fe2(μ‐OMe)2 core were studied as models of the active site of nonheme iron‐containing enzymes. X‐ray crystal structures of the complexes showed the existence of two types of ligand folding—parallel and twisted—both of which have four virtually equivalent phenolato groups sticking out from the Fe2O2 rhombic plane. Cyclic voltammetry measurements revealed two or more distinct redox waves in a region of relatively high potential, in addition to known FeII/FeIII redox waves in a region of lower potential. These new peaks were assigned to the high‐valence state of iron atoms, that is, FeIIIFeIV and FeIVFeIV, resonating with the phenoxyl radical(s). The split width of the redox waves ranged from 0.14 to 0.20 eV, which may be a measure of the electronic interaction of the phenolate groups through the Fe2(μ‐OMe)2 core.
Synthesis and Determination of the Absolute Configuration of Fugomycin and Desoxyfugomycin: CD Spectroscopy and Fungicidal Activity of Butenolides
Authors: Braun Manfred , Hohmann Andreas , Rahematpura Jaykumar , Bühne Corinna , Grimme Stefan 
Published: August 2004

AbstractThe dibromoalkenes (S)‐3 and (R)‐ and (S)‐4 are intermediates in the syntheses of the naturally occurring fungicidal butenolides fugomycin (1) and desoxyfugomycin (2), respectively. The stereoselective bromine–lithium exchange that leads to the carbenoid 12 and the vinyllithium reagent 17 a on the one hand, and palladium‐catalyzed coupling reactions of the dibromoalkene 3 and the bromolactone 22 on the other are key steps en route to the butenolides 1 and 2. The chiral building blocks (S)‐3, (R)‐4, and (S)‐4 are readily available from (R)‐isopropylideneglyceraldehyde 5, isobutyl (R)‐lactate 6 a, and ethyl (S)‐lactate 6 b, respectively. The synthetic procedure adopted here permits the absolute configuration of the natural products fugomycin (1) and desoxyfugomycin (2) to be assigned by comparison of their chiroptical properties with those of the synthetic products. The CD spectra of the bromolactone 22, calculated by two different density functional methods (TDDFT, DFT/MRCI), are found to be in good agreement with the measured spectra. On the basis of these calculations, the two CD bands observed could be assigned to n–π* and π–π* transitions, respectively. Fugomycin (1) and the synthetic butenolide 20 displayed high fungicidal activity against botrytis in greenhouse experiments, whereas the saturated lactone 21 was practically inactive.
Ligand Lability and Chirality Inversion in Yb Heterobimetallic Catalysts
Authors: Di Bari Lorenzo , Lelli Moreno , Salvadori Piero 
Published: August 2004

AbstractWe have investigated the exchange dynamics between the free and bound ligand in K3[Yb{(R)‐binol}3], the most active heterobimetallic lanthanoid catalyst for cyclic imine hydrophosphonylation; we found that the Yb–binol bond is labile. The rate constant for this exchange was determined through NMR saturation transfer experiments. Upon addition of (S)‐binaphthol, ligand exchange leads to the formation of a small quantity of heterochiral complexes and, in the presence of a molar excess of (S)‐binaphthol, to chirality inversion of the whole complex. This demonstrates that, in contrast to other analogous systems, K3[Yb(binol)3] displays a strong chiral discrimination, with the overwhelming preference for ligands of the same configuration. The lability of Yb–binol bond in THF may suggest a ligand‐to‐substrate exchange as a key step in the catalytic process.
Gas‐Phase Structure, Conformation, and Sulfur 2p Photoelectron Spectroscopy of Pentafluorosulfur Fluorosulfonate, SF5OSO2F
Authors: Leibold Christiane , Oberhammer Heinz , Thomas T. Darrah , Saethre Leif J. , Winter Rolf , Gard Gary L. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Dawson Type Heteropolyanions. Part 3. Syntheses and 31P, 51V, and 183W NMR Structural Investigation of Octadeca(molybdo‐tungsto‐vanado)diphosphates Related to the [H2P2W12O48]12‐ Anion.
Authors: Contant Roland , Abbessi Mostefa , Thouvenot Rene , Herve Gilbert 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Crystal Structure, and Molecular Modeling of a Layered Manganese(II) Phosphate: Mn3(PO4)4×2 (H3NCH2CH2)3N×6 (H2O).
Authors: Thoma Steven G. , Bonhomme Francois , Cygan Randall T. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Enantioselective Addition of Phenylacetylene to Aldehydes Catalyzed by a Camphorsulfonamide Ligand.
Authors: Xu Zhaoqing , Chen Chao , Xu Jiangke , Miao Mingbo , Yan Wenjin , Wang Rui 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric 1,4‐Reductions of Hindered β‐Substituted Cycloalkenones Using Catalytic SEGPHOS—Ligated CuH.
Authors: Lipshutz Bruce H. , Servesko Jeff M. , Petersen Tue B. , Papa Patrick P. , Lover Andrew A. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction Between Nitrogen—Containing Heterocycles and Dialkyl Acetylenedicarboxylate with Strong CH‐Acid: Synthesis of Stable Highly Functionalized 1,4‐Diionic Nitrogen Betaines.
Authors: Shaabani Ahmad , Bazgir Ayoob , Tavasoli‐Rad Farahnaz , Bijanzadeh Hamid Reza , Razmara Freidoon 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Approach to 2,2‐Disubstituted Chromenes and Tetrahydroquinolines Through Intramolecular Cyclization of Chiral 3,4‐Epoxy Alcohols.
Authors: Goujon Jean‐Yves , Zammattio Francoise , Chretien Jean‐Mathieu , Beaudet Isabelle 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Anomeric Oxygen to Carbon Rearrangements of Alkynyl Tributylstannane Derivatives of Furanyl (γ)‐ and Pyranyl (δ)‐Lactols.
Authors: Buffet Marianne F. , Dixon Darren J. , Ley Steven V. , Reynolds Dominic J. , Storer R. Ian 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nanoflow System for Perfect Regiocontrol in the Baeyer—Villiger Oxidation by Aqueous Hydrogen Peroxide Using Lowest Concentration of a Fluorous Lanthanide Catalyst.
Authors: Mikami Koichi , Islam Md. Nazrul , Yamanaka Masahiro , Itoh Yoshimitsu , Shinoda Masaki , Kudo Kenichi 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
4‐(tert‐Butyldimethylsilyloxy)benzylidene Acetal: A Novel Benzylidene‐Type Protecting Group for 1,2‐Diols.
Authors: Kaburagi Yosuke , Osajima Hiroyuki , Shimada Kousei , Tokuyama Hidetoshi , Fukuyama Tohru 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Oxidative Deprotection of Trimethylsilyl Ethers Using Bismuth Nitrate Supported onto Montmorillonite k‐10 under Microwave Irradiation in Solventless System.
Authors: Heravi Majid M. , Oskooie Hossein A. , Yazdanpanah Sedigheh , Mojtahedi Majid 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Two New Families of Fluorinated Compounds: 1H,1H,2H,2H‐Perfluoro‐3,5‐alkyldiynols and 1H,1H‐Perfluoro‐2,4‐alkyldiynols and Their Acrylates and Methacrylates.
Authors: Robert‐Estelrich Ana , Castella‐Matinez Merce , Lopez‐Calahorra Francisco 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Reaction of 4‐Cyclopentene‐1,3‐diol Monoacetate with Grignard Reagents Producing Hitherto Unreachable cis‐1,2‐Isomers.
Authors: Hattori Hatsuhiko , Abbas Ashraf A. , Kobayashi Yuichi 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Highly Efficient Oxidation of Cyclohexane over Au/ZSM‐5 Molecular Sieve Catalyst with Oxygen as Oxidant.
Authors: Zhao Rui , Ji Dong , Lv Gaomeng , Qian Guang , Yan Liang , Wang Xiaolai , Suo Jishuan 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Synthesis of Cyclic α‐Amino Aldehydes, Amino Alcohols, and α‐Amino Acid Methyl Esters from Cyclic Ketones Through Sulfinylaziridines.
Authors: Ota Hiroyuki , Chyouma Toshio , Iso Shuyu , Satoh Tsuyoshi 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Intramolecular Cyclization of 2‐(Buta‐1,3‐dienyl)‐3‐methylpyrazines and 3‐(Buta‐1,3‐dienyl)‐4‐methyl‐1,2,5‐oxadiazoles into 5H‐Cycloheptapyrazines and 4H‐Cyclohepta‐1,2,5‐oxadiazoles.
Authors: Matsumoto Masakatsu , Hoshiya Naoyuki , Isobe Ryo , Watanabe Yukie , Watanabe Nobuko 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cycloaddition Between Electron‐Deficient Partners: An Efficient Regio‐ and Stereoselective Synthesis of Functionalized Bicyclo[2.2.2]octenones. A Tandem Alkylation, Stereochemical Inversion and Aldol Condensation.
Authors: Singh Vishwakarma , Praveena G. D. , Mobin Shaikh M. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Phenyl Trifluorovinyl Sulfide: A Radical Acceptor for Preparation of gem‐Difluoromethylene Compounds.
Authors: Okano Takashi , Chokai Masayuki , Hiraishi Makiko , Yoshizawa Michito , Kusukawa Takahiro , Fujita Makoto 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐4‐Methansulfonamidobenzyl‐N′‐2‐substituted‐4‐tert‐butyl‐benzyl Thioureas as Potent Vanilloid Receptor Antagonistic Ligands.
Authors: Park Hyeung‐geun , et al. et al. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Microwave‐Accelerated Solventless Sonogashira‐Like Coupling Reaction of 1,1‐Dibromo‐1‐alkenes with Organic Halides on Nickel(0) Powder‐Doped KF/Al2O3.
Authors: Yan Jincan , Wang Zhiyuan , Wang Lei 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design and Synthesis of Macrocyclic Inhibitors of Phosphatase Cdc25B.
Authors: Baeurle Stefan , Blume Thorsten , Guenther Judith , Henschel Daniela , Hillig Roman C. , Husemann Manfred , Mengel Anne , Parchmann Christian , Schmid Elke , Skuballa Werner 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Easy Access to N‐Alkylation of N‐Unsubstituted [60]Fulleropyrrolidines: Reductive Amination Using Sodium Triacetoxyborohydride.
Authors: Xiao Shengqiang , Li Yongjun , Li Yuliang , Liu Huibiao , Li Hongmei , Zhuang Junpeng , Liu Yang , Lu Fushen , Zhang Deqing , Zhu Daoben 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Evaluation of Novel, Selective, Nonsteroidal Glucocorticoid Receptor Antagonists.
Authors: Akritopoulou‐Zanze Irini , Patel Jyoti R. , Hartandi Kresna , Brenneman Jehrod , Winn Martin , Pratt John K. , Grynfarb Marlene , Goos‐Nisson Annika , von Geldern Thomas W. , Kym Philip R. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactivity of Azafulvenium Methides Derived from Pyrrolo[1,2‐c]thiazole‐2,2‐dioxides: Synthesis of Functionalized Pyrroles.
Authors: Pinho e Melo Teresa M. V. D. , Soares Maria I. L. , Rocha Gonsalves Antonio M. d'A. , McNab Hamish 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation of 3‐Arylmethylindoles as Selective COX‐2 Inhibitors.
Authors: Campbell Jeffrey A. , Bordunov Viola , Broka Chris A. , Dankwardt John , Hendricks Robert T. , Kress James M. , Walker Keith A. M. , Wang Jin‐Hai 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel Derivatives of 4‐Amino‐3,5‐dicyanopyrazole.
Authors: Goncalves M. Sameiro T. , Oliveira‐Campos Ana M. F. , Rodrigues Ligia M. , Proenca M. Fernanda R. P. , Griffiths John , Maia Hernani L. S. , Kaja Martin , Hrdina Radim 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3‐Aryl(hetaryl)‐4‐ (2‐cyanophenyl)‐Δ2‐1,2,4‐triazolin‐5‐ones.
Authors: Stankevicius A. P. , Terentiev P. B. , Janushene L. N. , Zhevzhikoviene A. A. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Conversion of Coumarins Accompanied by Opening and Recyclization of the Lactone Ring. Part 1. Study of the Reaction of 3‐Ethoxycarbonyl(3‐acyl)coumarins with Cyanoacetylhydrazine and Its Derivatives.
Authors: Nemeryuk M. P. , Dimitrova V. D. , Anisimova O. S. , Sedov A. L. , Solov'eva N. P. , Traven V. F. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Evaluation of Substituted 4‐Alkoxy‐2‐aminopyridines as Novel Neuropeptide Y1 Receptor Antagonists.
Authors: Sato Nagaaki , Shibata Takunobu , Jitsuoka Makoto , Ohno Toshiyuki , Takahashi Toshiyuki , Hirohashi Tomoko , Kanno Tetsuya , Iwaasa Hisashi , Kanatani Akio , Fukami Takehiro 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lipophilic 4‐Imidazolyl‐1,4‐dihydropyridines: Synthesis, Calcium Channel Antagonist Activity and Protection Against Pentylenetetrazole‐Induced Seizure.
Authors: Navidpour Latifeh , Shafaroodi Hamed , Miri Ramin , Dehpour Ahmad Reza , Shafiee Abbas 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactions of Polyhalopyridines. Part 17. Synthesis of 2‐, 3‐ and 4‐Perfluoroalkylthiopolychloropyridines.
Authors: Sipyagin A. M. , Enshov V. S. , Boiko G. N. , Lebedev A. T. , Karakhanova N. K. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
N,N‐Dialkyl‐4‐[(8‐azabicyclo [3.2.1]‐oct‐3‐ylidene)phenylmethyl]benzamides, Potent, Selective δ Opioid Agonists.
Authors: Carson John R. , Coats Steven J. , Codd Ellen E. , Dax Scott L. , Lee Jung , Martinez Rebecca P. , Neilson Lou Anne , Pitis Philip M. , Zhang Sui‐Po 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐Azaindolizine Derivatives by the Palladium‐Catalyzed Intermolecular Formal [3 + 2] Cycloaddition of Alkylidenecyclopropanes with 1,2‐Diazines.
Authors: Siriwardana Amal I. , Nakamura Itaru , Yamamoto Yoshinori 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Tetrazolo[1,5‐a]quinoline as a Potential Promising New Scaffold for the Synthesis of Novel Antiinflammatory and Antibacterial Agents.
Authors: Bekhit Adnan A. , El‐Sayed Ola A. , Aboulmagd Elsayed , Park Ji Young 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design, Synthesis, and SAR of 2‐Dialkylamino‐4‐arylpyrimidines as Potent and Selective Corticotropin‐Releasing Factor1 (CRF1) Receptor Antagonists.
Authors: Huang Charles Q. , Grigoriadis Dimitri E. , Liu Zhengyu , McCarthy James R. , Ramphal John , Webb Thomas , Whitten Jeffrey P. , Xie Michael Y. , Chen Chen 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Preparative Method for Synthesis of Isoindolo[2,1‐b]benz‐2‐azepine‐8‐carboxylic Acids.
Authors: Zubkov F. I. , Boltukhina E. V. , Krapivko A. P. , Varlamov A. V. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Reaction of Phosphorylated N‐Sulfonylimines with Hydrophosphoryl Agents Involving C→N Transfer of Phosphoryl Groups.
Authors: Rassukana Yuliya V. , Onys'ko Petro P. , Davydova Kateryna O. , Sinitsa Anatolii D. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Crystal Structure of (Z)‐1‐(Triphenylstannyl)‐3‐p‐chlorophenyl‐1‐butene‐3‐ol.
Authors: Li Xing‐Qi , Zhu Dong‐Sheng , Du Xi‐Guang , Shao Kui‐Zhan , Yang Xing‐Hua 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hydrophobic Aminostyryl Quinolinium Dyes as New Fluorescent Stains for Proteins in Sodium Dodecyl Sulfate‐polyacrylamide Gel
Authors: Hong Sooyeon , Yoon Seung Soo , Kang Chulhun , Suh Myungkoo 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Leucosceptrine (I) — A Novel Sesterterpene with Prolylendopeptidase Inhibitory Activity from Leucosceptrum canum
Authors: Choudhary Muhammad Iqbal , Ranjit Rosa , Atta‐ur‐Rahman Atta‐ur‐Rahman , Shrestha Tirtha Maiya , Yasin Amsha , Parvez Masood 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Cytotoxic and Antitumor Activity of 1,2‐Dihydroxy‐1,2‐dihydrobenzo[b]acronycine Diacid Hemiesters and Carbamates.
Authors: Doan Thi Mai Huong , Gaslonde Thomas , Michel Sylvie , Koch Michel , Tillequin Francois , Pfeiffer Bruno , Renard Pierre , Kraus‐Berthier Laurence , Leonce Stephane , Pierre Alain 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Acyclonucleoside Iron Chelators of 1‐(2‐Hydroxyethoxy)methyl‐2‐alkyl‐3‐hydroxy‐4‐pyridinones: Potential Oral Iron Chelation Therapeutics.
Authors: Liu Gang , Men Ping , Kenner Gerry H. , Miller Scott C. , Bruenger Fred W. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Abyssomicin C:A Polycyclic Antibiotic from a Marine Verrucosispora Strain as an Inhibitor of the p‐Aminobenzoic Acid/Tetrahydrofolate Biosynthesis Pathway.
Authors: Bister Bojan , Bischoff Daniel , Stroebele Markus , Riedlinger Julia , Reicke Andreas , Wolter Falko , Bull Alan T. , Zaehner Hans , Fiedler Hans‐Peter , Suessmuth Roderich D. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Meridianins, a New Family of Protein Kinase Inhibitors Isolated from the Ascidian Aplidium meridianum.
Authors: Gompel Marie , Leost Maryse , Bal De Kier Joffe Elisa , Puricelli Lydia , Hernandez Franco Laura , Palermo Jorge , Meijer Laurent 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens
Authors: Weng Jing‐Ru , Ko Horng‐Huey , Yeh Ting‐Li , Lin Hsien‐Cheng , Lin Chun‐Nan 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Isopropyl Amide Derivatives of Potent and Selective Muscarinic M2 Receptor Antagonists.
Authors: Palani Anandan , Dugar Sundeep , Clader John W. , Greenlee William J. , Ruperto Vilma , Duffy Ruth A. , Lachowicz Jean E. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Total Syntheses of Iso‐, Neuro‐ and Phytoprostanes: New Insight in Lipid Chemistry
Authors: Durand Thierry , Guy Alexandre , Henry Olivier , Roland Arlene , Bernad Stephane , El Fangour Siham , Vidal Jean‐Pierre , Rossi Jean‐Claude 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Coupling Techniques of 2‐Methyl‐4‐aryl‐1,2,3,4‐Tetrahydroisoquinolines: Application to the Synthesis of the Cherylline and Latifine Alkaloids
Authors: Lebrun Stephane , Couture Axel , Grandclaudon Pierre 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Time interval to the development of breast carcinoma after treatment for Hodgkin disease
Authors: Wendland Merideth M. M. , Tsodikov Alexander , Glenn Martha J. , Gaffney David K. 
Published: August 2004

AbstractBACKGROUNDWomen with Hodgkin disease (HD) who received mantle irradiation had an increased risk of developing breast carcinoma. The authors examined the influence of radiotherapy on the time interval to the development of breast carcinoma.METHODSUsing population, cancer incidence, and survival data from the Surveillance, Epidemiology, and End Results (SEER) registries, standardized incidence ratios (SIR) were calculated and Kaplan–Meier curves were constructed to estimate breast carcinoma‐free survival in women with HD treated with and without radiotherapy. The log‐rank test was utilized and multivariate proportional hazard regression analysis was performed. Multivariate analysis was also performed using the PHPH regression model.RESULTSIn 9 SEER registries, 8036 females were identified who were diagnosed with HD between 1973 and 1999. Of these women, 183 (2.3%) were subsequently diagnosed with breast carcinoma. The use of radiotherapy in the treatment of HD resulted in an increased risk of development of breast carcinoma (SIR = 1.90, P < 0.01). The log‐rank test and proportional hazard regression model failed to detect a difference (P = 0.79) in breast carcinoma‐free survival for women treated with and without radiotherapy. The PHPH regression model revealed that the use of radiotherapy had an adverse effect on long‐term survival (relative risk [RR] = 1.84, P = 0.01), but was associated with a short‐term survival advantage (RR = 0.45, P = 0.01).CONCLUSIONSUse of the PHPH model indicated that the use of radiotherapy in the treatment of HD resulted in an increased long‐term risk for the subsequent development of breast carcinoma, but conferred a short‐term reduction. Cancer 2004. © 2004 American Cancer Society.