bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Division of the Paramedian Forehead Flap: A Systematic Review and Retrospective Analysis
Authors: Ma Connie C. , Si Clara , Adegboye Feyisayo , Lee Jaclyn , Lee Ina , Stephan Scott J. , Patel Priyesh N. , Yang Shiayin F. 
Published: January 2025

ObjectiveTo determine whether and when early division of the paramedian forehead flap may be safely performed.Data SourcesPubMed (NLM), Scopus (Elsevier), and Embase (Elsevier).MethodsA systematic search of PubMed, Scopus, and Embase was conducted according to PRISMA guidelines. Data extraction included time to pedicle division, patient and defect characteristics, and postoperative complications. Additionally, a retrospective analysis of patients at our institution was performed to augment the cohort.ResultsA total of 103 patients (85 from 6 studies identified via systematic review and 18 via retrospective review) underwent early flap division defined as 16 days and earlier. The average time to division was 9.89 days (3–16). There were no cases of flap loss, and complications were rare. Several studies excluded full thickness defects. Five studies included patients requiring cartilage grafting, although some limited this to less than 50% of the defect area. All patients in our retrospective cohort had partial thickness defects and none required cartilage grafting. Despite smoking being a major risk factor for vascular disease, 13.7% of patients were current smokers. Several studies utilized imaging tools such as indocyanine green angiography to assess flap perfusion. Notably, in these instances, no cases were delayed due to lack of adequate neovascularization.ConclusionEarly paramedian forehead flap division may be an option in select patients with partial thickness nasal defects. Adjunct imaging may be a cost‐effective method of evaluating appropriate timing of division.Level of EvidenceNA Laryngoscope, 2025
Multitemporal Analysis of Land Cover Changes in the Rabanal Páramo Ecosystem (Colombia) From 2000 to 2020 and Its Planning Regulations
Authors: Vergara Paulina , Llorente Irene De Pellegrin 
Published: January 2025

ABSTRACTThe páramos, with their high biodiversity and benefits to humanity, are crucial ecosystems in Colombia. Despite their importance, there is a significant knowledge gap regarding the extent of land cover changes and the identification of planning regulatory milestones on these ecosystems. The Rabanal Páramo Regional District, a water supplier for the capital city of Tunja, is under threat. The protected area faces land use conflicts, and updated information needs to be provided on how natural covers have been affected by grazing or the expansion of the agricultural frontier. Considering this, the main goal of this research was to recognize land cover changes in the Rabanal Páramo from 2000 to 2020. To achieve this, we conducted a multi‐temporal analysis using the Corine Land Cover methodology adapted for Colombia. Additionally, we identified the various planning regulations that have contributed to this ecosystem's conservation and restoration efforts. Results showed that the bush cover has significantly decreased, from 27.9% of the total area in 2000 to 20.5% in 2020. In contrast, the mosaic of crops, pastures, and natural spaces has expanded from 2.5% of the total area in 2000 to 8.1% in 2020. The primary strategy in the páramo management plan involves using zoning and land type regulations. Urgent action is needed to balance the demands of agricultural development with the preservation of the páramo ecosystem to ensure a sustainable existence between human activities and the environment.
Enhancing Detection Capability of Orbital Angular Momentum Sorter
Authors: Yan Rong , Ahmed Hammad , Ansari Muhammad Afnan , Wang Guanchao , Zhang Chunmei , Li Li , Tian Hao , Bian Liheng , Chen Xianzhong 
Published: January 2025

AbstractEach photon in a vortex beam carries an orbital angular momentum (OAM). OAM detection plays a very important role in unlocking the new capability of vortex beams in both fundamental research and technological advancements. As the number of information channels continues to grow, there is an urgent need to improve the detection capability of the OAM sorting system. The unprecedented capability of optical metasurfaces has provided an opportunity to realize OAM detection in a compact platform. Different OAM modes are typically separated into distinct light spots in OAM sorting. However, each spot in an OAM sorting system is tailored to recognize only one predesigned OAM mode. A metasurface approach to detecting more OAM modes with the same number of light spots in the observation plane is demonstrated. The conservation of momentum in the design is realized with a customized multifoci metalens. The efficacy of this method is exemplified through the detection of two OAM modes in an individual light spot, dramatically increasing the detection capability of the OAM sorter. It is anticipated that this design will reduce the demand for spatial resources, creating new opportunities to explore OAM applications across many research fields such as optical communications and quantum science.
Synergistic Effect of MgO/ZnO on β‐Phase Crystallization in PVDF: A Comparative Study of Mode of Nanofiller Additions for Piezoelectric Applications
Authors: Bodhi T K Kavya , Kurup Hridya P , Verma Ankur , Karumuthil Subash Cherumannil 
Published: January 2025

AbstractThis study pioneers the investigation into the critical role of the nanofiller addition method in enhancing β‐phase crystallization in polyvinylidene fluoride (PVDF). Hydrothermally synthesized magnesium oxide (MgO) nanoparticles are combined with zinc oxide (ZnO) in two approaches, yielding optimized electroactive properties. Characterization via Attenuated Total Reflectance Fourier Transformed Infrared Spectroscopy (ATR‐FTIR) and X‐ray Diffraction (XRD) confirmed the improved β‐phase crystallization in P/ZM10 film. The superior sensitivity with fast, linear and precise pattern detection of the optimised polymer composite device ensures its usage as a piezoelectric sensor system. Under the realistic irregular hand‐tapping of 22–23 N force, the fabricated prototype generated an output voltage of 96 V and displayed a maximum power density of 66.69 µW cm−2. A laboratory‐level demonstration of the prototype as a piezoelectric sensor in water filters enables its efficiency and feasibility for real‐time applications.
Stimuli‐Responsive Functional Polymeric Materials: Recent Advances and Future Perspectives
Authors: Dolui Subrata , Sahu Bhanendra , Banerjee Sanjib 
Published: January 2025

AbstractInspired by the extreme structural complexity and functional efficiency of biomolecules, researchers have developed stimuli‐responsive materials, capable of adapting their structural conformations and physicochemical properties upon external changes in temperature, pH, light, etc. These materials can expand, contract, or bend in response to external stimuli, which makes them useful for a variety of applications such as biomedicine, sensors, shape‐memory devices, and smart interface materials. Multistimuli‐responsive materials exhibit enhanced features than single‐/dual‐responsive materials, affording enhanced fine tuning of their parameters. Among such materials, reversibly cross‐linked networks have generated increasing interest recently due to their 3D architecture and unique properties, based on the low viscosity, good solubility, and high functionality of the building blocks, which can be further modified. In order to achieve dynamic self‐assembly, future research on stimuli‐responsive macromolecular self‐assembly should mimic thec structures, functions, and processes found in nature.
Salt‐inducible kinase 2 confers radioresistance in colorectal cancer by facilitating homologous recombination repair
Authors: Meng Yuan , Li Shuo , Lu Da‐Shan , Chen Xue , Li Lu , Duan You‐fa , Wang Gao‐yuan , Huang Wenlin , Liu Ran‐yi 
Published: January 2025

AbstractResistance to radiotherapy remains a critical barrier in treating colorectal cancer (CRC), particularly in cases of locally advanced rectal cancer (LARC). To identify key kinases involved in CRC radioresistance, we employed a kinase‐targeted CRISPR‐Cas9 library screen. This approach aimed to identify potential kinase inhibitors as radiosensitizers. Our screening identified salt‐inducible kinase 2 (SIK2) as a critical factor in CRC radioresistance. Increased SIK2 expression correlated with reduced tumor regression and poorer outcomes in LARC patients undergoing neoadjuvant chemoradiotherapy. The depletion of SIK2 significantly enhanced radiation‐induced apoptosis and tumor regression. Mechanistically, SIK2 interacts with valosin‐containing protein (VCP), promoting its hyperphosphorylation. This modification improves VCP's capacity to extract K48‐linked ubiquitin‐conjugated proteins from chromatin, thus aiding the recruitment of RPA and RAD51 to DNA damage sites. This mechanism strengthens homologous recombination–mediated DNA repair, which contributes to radioresistance. Importantly, ARN‐3236, a SIK2 inhibitor, markedly sensitized CRC cells to radiation both in vivo and in vitro, providing a potential strategy to overcome radioresistance. In summary, our findings reveal a novel mechanism by which SIK2 contributes to the radioresistance of CRC, proposing SIK2 as a potential therapeutic target with its inhibitor significantly enhancing CRC radiotherapy efficacy.
Compensating College Football Players for Their Name, Image, and Likeness Rights From Live College Football Broadcasts
Authors: Brook Stacey L. 
Published: January 2025

ABSTRACTRecently, the NCAA has allowed student athletes to be compensated by third parties for their name, image, and likeness rights (NIL) but not their NIL rights from televised broadcasts. Yet these rights have an economic value. A counterfactual model is employed to determine how university media rights revenues relate to television viewership, and then, the model is empirically estimated to determine the value of these NIL rights. The results show the median athletic department would pay about 5.4% of their football media rights revenue to the football participants, and the median football participant would be paid $4739 for their NIL rights.
Extended Two‐Step Ulm‐Chebyshev‐Like Method for Inverse Singular Value Problems With Multiple And/Or Zero Singular Values
Authors: Ma Wei , Gao Jingli , Ji Nuo 
Published: January 2025

ABSTRACTIn this article, we study the convergence of an extended two‐step Ulm–Chebyshev‐like method for solving the inverse singular value problems with multiple and/or zero singular values. Under the assumption of nonsingularity of the relative generalized Jacobian at a solution, the cubic convergence result is established for the extended two‐step Ulm–Chebyshev‐like method, and numerical experiments are provided to illustrate the convergence performance of the extended method. the research results in the present article significantly improve and expand Ma's corresponding results [18] for the special cases of distinct and positive singular values.
Measuring the Human Values That Predominate in the Organization's Culture: A Dynamic Multilevel Linear Mixed Model Based on Genetic Algorithms
Authors: Molina‐Sánchez Horacio , Ortiz‐Gomez Mar , Fernández‐Navarro Francisco 
Published: January 2025

ABSTRACTThe alignment between organizational and employee human values is critical in institutions that base their management on values. This research aims to link Schwartz's 10 human values to workplace authenticity, determining prevalent values in organizations. In tandem, nonprofit organizations are intricately intertwined with the values held by their members, forming the bedrock of their identity. To achieve this goal, an in‐depth analysis is conducted on three nonprofit and faith‐based organizations. The study proposes a hybrid model, merging a genetic algorithm with a linear mixed model, to comprehensively explore the intricate relationship between employees’ human values and authenticity in organizational settings. The underlying model is estimated from data to theory using a genetic algorithm (global optimization) to dynamically determine the best set of human values regressors (also considering interaction effects). The regressors selected to explain the authenticity construct the most from two perspectives, namely, the general model (fixed effects) and the particular model (random effects).
Systemic Inflammatory Diseases in Children with Sickle Cell Disease: A French Multicenter Observational Study on Diagnostic and Therapeutic Issues
Authors: Vinit Caroline , Guitton Corinne , De Montalembert Mariane , Benhaim Patricia , Amor‐Chelihi Lahoueri , Bader‐Meunier Brigitte , Missud Florence , Melki Isabelle , Gajdos Vincent , Arnaud Cécile , Kamden Annie , Charara Oussama , Hentgen Véronique , Nathanson Sylvie , Bloch Coralie , Meinzer Ulrich , Quartier Pierre , Kone‐Paut Isabelle , De Pontual Loïc , Pham Luu‐Ly 
Published: January 2025

ABSTRACTBackgroundSystemic inflammatory diseases (SIDs) have been reported in patients with sickle cell disease (SCD), but clinical data in children are scarce.ObjectivesTo identify clinical and laboratory features at diagnosis of SID in children with SCD and to describe their evolution.MethodsData from children with SCD and SIDs were retrospectively collected in a French multicenter study from 1991 to 2018. Information included clinical characteristics, inflammatory markers, autoantibodies patterns, treatments, and complications. Inflammatory marker levels were compared at SID diagnosis and at the last follow‐up. Statistical analyses were performed using Cran R software.ResultsAmong a cohort of 3800 children with SCD, 43 SIDs were identified in 35 study participants: autoimmune liver disease (AILD, n = 13), inflammatory bowel disease (IBD, n = 7), juvenile idiopathic arthritis (JIA, n = 6), systemic lupus erythematosus (n = 4), autoimmune hemolytic anemia (n = 3), Sjögren syndrome (n = 1), histiocytic necrotizing lymphadenitis (n = 2), vasculitis (n = 2), myasthenia gravis (n = 1), sarcoidosis (n = 1), idiopathic inflammatory granulomatous uveitis (n = 1), mixed connective tissue disease (n = 2). Prevalence of SID was 0.9% in our cohort of children with SCD. The median time between initial symptoms and SID diagnosis was 10 (3–20) months, notably longer in children with JIA, IBD, and Sjögren syndrome. Sixteen patients (46%) exhibited hypergammaglobulinemia (>20 g/L) at diagnosis. No significant differences were observed for other inflammatory parameters. Twenty‐one children (60%) received systemic steroids and 13 (37%) biological therapies. Three patients (9%) underwent hematopoietic stem cell transplantation. Nine patients (26%) had severe infections; one died.ConclusionDelayed diagnosis was frequent due to overlapping clinical presentations between SCD and SID. Clinicians must be aware of warning signs associated with elevated inflammatory markers, hypergammaglobulinemia, or specific antibodies. Therapeutic strategies remain challenging.
DFT Insights Into Non‐Catalytic Aminolysis of Polycarbonates
Authors: Samuilov Alexander Y. , Ali Amran Abdullah Ghilan , Samuilov Yakov D. 
Published: January 2025

ABSTRACTThe problem of environmental pollution by plastic is becoming more and more obvious. In this study, the non‐catalytic reaction of diphenyl carbonate with methylamine as a model reaction for the depolymerization of polycarbonate was studied at the B3LYP/6‐31++G(d,p) and M062X/6‐31++G(d,p) levels. The reaction can proceed by the nucleophilic substitution and by the “addition–elimination” pathways. Calculations at the B3LYP/6‐31++G(d,p) level indicate that the reaction of diphenyl carbonate with methylamine monomer leading to the formation of N‐methyl‐O‐phenylcarbamate via the nucleophilic substitution pathway at 298 K is characterized by activation and reaction free energies equal to 174.0 and −57.1 kJ·mol−1. The same reaction with methylamine dimer is characterized by activation and reaction free energies equal to 147.1 and −77.7 kJ·mol−1, respectively. Thermodynamic and kinetic preference is also observed in the reaction of N‐methyl‐O‐phenylcarbamate with the monomer and dimer of methylamine. Reactions with the formation of tetrahedral intermediates are unlikely. Their formation is endothermic and occurs with a decrease in entropy. This leads to small values of equilibrium constants. The equilibrium constant of the reaction of diphenyl carbonate with methylamine monomer to form a tetrahedral intermediate is 1.64·10−16 at 298 K and 1.20·10−14 at 423 K. The same trends are observed in the reactions of N‐methyl‐O‐phenylcarbamate. The reactions of diphenyl carbonate, N‐methyl‐O‐phenylcarbamate with methylamine dimer via the “addition–elimination” pathway are also characterized by small values of equilibrium constants. In all cases, interactions involving the methylamine dimer are more favorable than reactions involving the methylamine monomer.
Cotton leaf curl Multan virus activates autophagy in the whitefly AsiaII7, weakening its vectorial capacity for transmission
Authors: Chen Ting , Jia Yanbo , Tang Yafei , Chen Jie , Xu Haiyun , Qi Guojun 
Published: January 2025

AbstractBACKGROUNDAutophagy plays an important role against pathogen infections in both insects and plants. Insect vectors employ autophagy as an intrinsic antiviral defense mechanism against viral infections, whereas viruses can exploit autophagy to enhance their transmission via insect vectors. The Cotton leaf curl Multan virus (CLCuMuV) is transmitted by the AsiaII7 cryptic species of Bemisia tabaci, however, the role of autophagy is involved in regulating the transmission of this virus remains unclear.RESULTIn this study, it was observed that CLCuMuV infection induced autophagy in AsiaII7 whitefly, as evidenced by an elevated in the level of ATG8‐II and the upregulation of Atg3, Atg8, Atg9 and Atg12. Both the administration of the autophagy inhibitor bafilomycin A1 and the silencing of Atg9 expression increased the viral load and enhanced CLCuMuV transmission. Conversely, the activation of autophagy via rapamycin feeding significantly reduced the amount of CLCuMuV and inhibited the efficiency of virus transmission.CONCLUSIONCLCuMuV infection can activate the autophagy pathway in whiteflies. The activation of autophagy leads to the subsequent degradation of the virus and suppresses CLCuMuV transmission efficiency, whereas suppression of autophagy promotes virus transmission. Our research provides insight into the potential role of autophagy in antiviral defense mechanisms. © 2025 Society of Chemical Industry.
Quercetin, a natural flavonoid induced by the spider mite Tetranychus urticae or alamethicin, is involved in the defense of lima bean against spider mites
Authors: Li Fengqi , Liu Junfang , Dewer Youssef , Ahsan Muhammad Haseeb , Wu Chunyan 
Published: January 2025

AbstractBACKGROUNDPhaseolus lunatus, commonly known as the lima bean, is a leguminous crop cultivated in various regions worldwide. It is native to tropical America and is extensively grown in both tropical and temperate climates. Lima beans are highly nutritious and versatile, serving not only as a food and vegetable, but also as a source of green manure. During cultivation, lima beans can be vulnerable to numerous pests, including the spider mite, Tetranychus urticae. In large‐scale outbreaks, T. urticae can cause significant yield losses or even crop failure, posing a serious threat to agricultural production. The treatment of lima bean plants with T. urticae or alamethicin (ALA) has been shown to enhance their insect‐resistant defense responses. Understanding the transcriptional and metabolic mechanisms underlying these defense responses to T. urticae and ALA is crucial for improving herbivore resistance in lima bean crops.RESULTBy integrated analysis of transcriptomics and metabolomics data, we found that both T. urticae and ALA treatments significantly induced the flavonoid biosynthesis pathway. Both treatments increased the flavonoid content in lima bean leaves by upregulating the expression of key genes in this pathway, potentially contributing to enhanced resistance to phytophagous insects. Notably, quercetin has been shown to reduce the number of eggs per female and survival rate of T. urticae.CONCLUSIONThese findings provide a novel theoretical basis for understanding the response mechanisms of lima beans to T. urticae and ALA, while highlighting potential metabolites and genes that could be targeted to improve plant resistance to spider mite damage. © 2025 Society of Chemical Industry.
Cleaning Robots: A Review of Sensor Technologies and Intelligent Control Strategies for Cleaning
Authors: Megalingam Rajesh Kannan , Vadivel Shree Rajesh Raagul , Kotaprolu Sai Smaran , Nithul Bagathi , Kumar Devisetty Vijay , Rudravaram Gaurav 
Published: January 2025

ABSTRACTCleaning robots have revolutionized the way spaces and surfaces are cleaned, accessing areas that are often difficult for humans to reach. A significant segment of the cleaning robot industry is dedicated to home cleaning robots, which have undergone numerous enhancements since their initial introduction. Through extensive research and development efforts, the application scope of cleaning robots has expanded beyond floors to encompass walls, staircases, pools, tanks, ventilation ducts, windows, and other surfaces. These robots have seen improvements in cleaning effectiveness through the integration of new designs, technologies, and control methods. This review paper presents a comprehensive analysis of cutting‐edge cleaning robots recently developed, exploring various sensor technologies and intelligent control strategies employed to enhance cleaning efficiency. Additionally, the paper discusses the challenges associated with deploying these robots in real‐world scenarios.
Mineralization potential of spent coffee grounds and other nutrient sources
Authors: Birnbaum Amanda L. , Howe Julie , Earp Ryan , Burke Joseph , Wherley Benjamin , Dhingra Amit 
Published: January 2025

AbstractIndustrial‐scale coffee ground waste has the potential to serve as a nutrient‐rich soil amendment, which would offer growers an opportunity to reduce applications of traditional fertilizers. Composted spent coffee grounds (CSCGs) and noncomposted spent coffee grounds (NCSCGs) were evaluated for their potential as organic N fertilizers. Nitrogen mineralization of NCSCGs and CSCGs was compared to commonly used synthetic and organic N fertilizers: urea and Milorganite. Net N mineralization and microbial activity were measured in a fine sandy loam field soil at 25°C and 60% water holding capacity weekly for 100 days. Despite a C:N of 13:1, the CSCGs appeared to have slow mineralization. Total inorganic N was lower in both CSCGs and NCSCGs than the control throughout the 100‐day incubation with no additional N to the system. Greater CO2─C respiration was recorded with SCGs, suggesting microbial activity is required for the breakdown of SCGs relative to other treatments. CSCGs may serve as a long‐term fertilizer due to the time it takes to mineralize; however, over a shorter period, it may increase the nutrient‐ and water‐holding capacity of soil, which can improve plant growth.