bluuebunny/crossref_metadata_2025_split huggingface dataset:
iPSI(2L)-EDL: a Two-layer Predictor for Identifying Promoters and their
Types based on Ensemble Deep Learning
Authors: Xiao Xuan , Hu Zaihao , Luo ZhenTao , Xu Zhaochun 
Published: October 2023

Abstract:
Promoters are DNA fragments located near the transcription initiation site, they can be divided
into strong promoter type and weak promoter type according to transcriptional activation and
expression level. Identifying promoters and their strengths in DNA sequences is essential for understanding
gene expression regulation. Therefore, it is crucial to further improve predictive quality of
predictors for real-world application requirements. Here, we constructed the latest training dataset
based on the RegalonDB website, where all the promoters in this dataset have been experimentally
validated, and their sequence similarity is less than 85%. We used one-hot and nucleotide chemical
property and density (NCPD) to represent DNA sequence samples. Additionally, we proposed an ensemble
deep learning framework containing a multi-head attention module, long short-term memory
present, and a convolutional neural network module.

:
The results showed that iPSI(2L)-EDL outperformed other existing methods for both promoter prediction
and identification of strong promoter type and weak promoter type, the AUC and MCC for
the iPSI(2L)-EDL in identifying promoter were improved by 2.23% and 2.96% compared to that of
PseDNC-DL on independent testing data, respectively, while the AUC and MCC for the iPSI(2L)-
EDL were increased by 3.74% and 5.86% in predicting promoter strength type, respectively. The results
of ablation experiments indicate that CNN plays a crucial role in recognizing promoters, the importance
of different input positions and long-range dependency relationships among features are
helpful for recognizing promoters.

:
Furthermore, to make it easier for most experimental scientists to get the results they need, a userfriendly
web server has been established and can be accessed at http://47.94.248.117/IPSW(2L)-EDL.
Role of Astrogliosis in the Pathogenesis of Parkinson’s Disease: Insights
into Astrocytic Nrf2 Pathway as a Potential Therapeutic Target
Authors: Bhushan Bharat , Singh Niraj Kumar 
Published: October 2023

Abstract::
Recently, Parkinson’s disease (PD) has become a remarkable burden on families and society
with an acceleration of population aging having several pathological hallmarks such as dopaminergic
neuronal loss of the substantia nigra pars compacta, α-synucleinopathy, neuroinflammation,
autophagy, last but not the least astrogliosis. Astrocyte, star-shaped glial cells perform notable
physiological functions in the brain through several molecular and cellular mechanisms including
nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. It has been well established that
the downregulation of the astrocytic Nrf2 signaling pathway plays a crucial role in the pathogenesis
of PD because it is a master regulator of cellular defense mechanism along with a regulator of numerous
detoxifying and antioxidant enzymes gene expression. Fascinatingly, upregulation of the astrocytic
Nrf2 signaling pathway attenuates the degeneration of nigrostriatal neurons, restores neuronal
proliferation, rejuvenates astrocytic functions, and exhibits neuroprotective effects via numerous
cellular and molecular mechanisms in the PD-like brain of the experimental animal. Here, we
discuss the numerous in-vitro and in-vivo studies that evaluate the neuroprotective potential of the
astrocytic Nrf2 signaling pathway against experimentally-induced PD-like manifestation. In conclusion,
based on available preclinical reports, it can be assumed that the astrocytic Nrf2 signaling
pathway could be an alternative target in the drug discovery process for the prevention, management,
and treatment of PD.
Protective Effect of Green Chiretta (Andrographis paniculata) against
Methotrexate-induced Cardio and Spleen Toxicity: In-vitro and In-vivo
Authors: Parthasarathy Manisha , Seenivasan Vijayadharshini , Nithiyanandam Sangeetha , Katturajan Ramkumar , Haraganahalli Bhasakarmurthy Deepak , Ganesan Raja , Valsala Gopalakrishnan Abilash , Ahmad Sheikh F. , Evan Prince Sabina 
Published: October 2023

Background::
Methotrexate (MTX) is a widely used medication for treating various conditions,
including skin infections, inflammatory diseases, autoimmune disorders, and malignancies.
However, prolonged and extreme use of MTX can lead to detrimental effects on multiple organs.
Green Chiretta (GC) is a traditional medicinal plant known for its anti-inflammatory, antioxidant,
and immunostimulatory properties.

Objective::
The objective of this study is to examine the antioxidant potential of GC through in-vitro
analysis and to assess the potential protective effects of aqueous leaf extracts of GC against MTXinduced
cardiac and spleen toxicity.

Methods::
In-vitro antioxidant activity was assessed by measuring total phenolic content, DPPH,
catalase and peroxidase activity. We divided rats into five groups (n=6), and after the study, rats
were euthanized and the levels of antioxidants (SOD, CAT & GSH) and lipid peroxidase (MDA), as
well as histopathology modification of the heart and spleen tissues were examined.

Results::
Our study's findings highlight the superiority of the aqueous GC extract's antioxidant capacity
relative to other solvents (ethanol and methanol). Moreover, the aqueous GC extract's administration
to rats yielded significant progress in antioxidant levels (Superoxide dismutase, catalase, glutathione),
a reduction in lipid peroxidation (MDA), and the restoration of cardiac and spleen histoarchitecture
against MTX-induced toxicity. These results collectively emphasize the extract's potential
as a valuable therapeutic option against oxidative stress and tissue damage.

Conclusion::
The present study revealed that the aqueous GC extract demonstrated its protective
efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats
Multi-objective Reactive Power Optimization of a Distribution Network
based on Improved Quantum-behaved Particle Swarm Optimization
Authors: Song Weifeng , Ma Gang , Zhao Yuxuan , Li Weikang , Meng Yuxiang 
Published: October 2023

Background:
Reactive power optimization (RPO) is crucial for distribution networks
in the context of large-scale renewable distributed generation (RDG) access.

Objective:
To address the problems caused by the connection of RDG, an RPO model and an improved
quantum-behaved particle swarm optimization (IQPSO) algorithm are proposed.

Method:
In this study, a dynamic S-type function is proposed as the objective function of the
minimum active power loss, whereas an exponential function is proposed as the objective function
of the minimum voltage deviation to establish an RPO objective function. The operating cost of
distribution is considered as the third objective function. To address the RPO problem, a QPSO
algorithm based on the ε-greedy strategy is proposed in this paper. ModifiedIEEE33 bus and
IEEE69 bus systems were used to evaluate the proposed RPO method in simulations.

Results:
The simulation results reveal that the IQPSO algorithm obtains a better solution, and the
proposed RPO model can considerably reduce active power loss, node voltage deviation, and distribution
network operating costs.

Conclusion:
The RPO model and IQPSO algorithm proposed in this study provide a highperformance
method to analyze and optimize reactive power management in distribution network.
Clinical study to evaluate the efficacy of Mentosoothe Compound in the management of Attention Deficit / Hyperactivity Disorder
Authors: Kumawat Shraddha , Rakesh Kumar Nagar  , Vishal Nandlal Prajapati  
Published: October 2023

Introduction: DSM-5 defines Attention-Deficit/Hyperactivity Disorder as having a persistent pattern of hyperactivity or inattention. This affects social, emotional, cognitive, and academic performance, behavioural skills in children and adolescents. The suffering child should have more than 6 symptoms of a particular type. Due to aetiology of Dhee Dhriti and Smriti, which results in imbalance of Kala and Karma and leads to incorrect interaction of the senses with their aims (Asatmyendriyartha Samyoga), gives rise to inattention, hyperactivity and impulsivity. Considering the nature of symptomatologic manifestation, it can be correlated with Unmada, more specifically Vata-Pittaja Unmada. Ayurveda addresses ADHD with both internal medicines and external therapies. Mentosoothe compound is such a polyherbal compound it contains Medhya, Balya, Deepana and Rasayana drugs in extract form. Aim of the present study to evaluate the efficacy of mentosoothe compound in the management of Attention-Deficit/Hyperactivity Disorder. Objective of the study is to promote cognitive performance with improvement in the quality of life by providing an effective and safe treatment option. Materials and Methods: The present study will be conducted as a randomized clinical study including minimum 40 patients, divided into two groups. Mentosoothe compound A and Mentosoothe compound B will be given to groups with fixed dosages. Assessment will be done on every 15th day during 2 months of clinical trial and final follow up will be done one month after completion of clinical trial. Result: The results will give the data on comparative effectiveness of the Mentosoothe compounds on ADHD. Discussion and Conclusion: The outcome of this trial will render a way forward to effective management of ADHD in children.
A Serious Game to Train Rhythmic Abilities in Children With Dyslexia: Feasibility and Usability Study
Authors: Vonthron Francois , Yuen Antoine , Pellerin Hugues , Cohen David , Grossard Charline 
Published: October 2023

Background
Rhythm perception and production are related to phonological awareness and reading performance, and rhythmic deficits have been reported in dyslexia. In addition, rhythm-based interventions can improve cognitive function, and there is consistent evidence suggesting that they are an efficient tool for training reading skills in dyslexia.

Objective
This paper describes a rhythmic training protocol for children with dyslexia provided through a serious game (SG) called Mila-Learn and the methodology used to test its usability.

Methods
We computed Mila-Learn, an SG that makes training remotely accessible and consistently reproducible and follows an educative agenda using Unity (Unity Technologies). The SG’s development was informed by 2 studies conducted during the French COVID-19 lockdowns. Study 1 was a feasibility study evaluating the autonomous use of Mila-Learn with 2500 children with reading deficits. Data were analyzed from a subsample of 525 children who spontaneously played at least 15 (median 42) games. Study 2, following the same real-life setting as study 1, evaluated the usability of an enhanced version of Mila-Learn over 6 months in a sample of 3337 children. The analysis was carried out in 98 children with available diagnoses.

Results
Benefiting from study 1 feedback, we improved Mila-Learn to enhance motivation and learning by adding specific features, including customization, storylines, humor, and increasing difficulty. Linear mixed models showed that performance improved over time. The scores were better for older children (P<.001), children with attention-deficit/hyperactivity disorder (P<.001), and children with dyslexia (P<.001). Performance improved significantly faster in children with attention-deficit/hyperactivity disorder (β=.06; t3754=3.91; P<.001) and slower in children with dyslexia (β=−.06; t3816=–5.08; P<.001).

Conclusions
Given these encouraging results, future work will focus on the clinical evaluation of Mila-Learn through a large double-blind randomized controlled trial comparing Mila-Learn and a placebo game.
Empowering Whistleblowing Policy within Public Listed Companies: Current Practice in Malaysia
Authors: Mohd Ali Nor Aishah , Mahat Zaleha , Abdullah Zaharah , Basri Siti Aisyah , Johari Norhanizah 
Published: October 2023

Whistleblowing is an act of disclosing any unethical or questionable act within an organization by disclosing them to individuals, the public or authorities that could influence the wrongdoing. It became an important part of the corporate governance process as such action would benefit society and the organization. With the increase in whistleblowing cases involving publicly listed companies (PLCs) by the mass media in Malaysia, there is a dearth of information on to what extent these PLCs manage whistleblowing matters. As a general practice, albeit not compulsory, many publicly listed companies disclose whistleblowing statements in their annual report. As this aspect of corporate governance for the employees is still unexplored, this study purports to explore the form of disclosure on whistleblowing policy by publicly listed companies in Malaysia for the financial year ending 2021. This study is a content analysis of 918 annual reports of companies listed in Malaysia. The findings reveal that most of the companies disclosed matters relating to whistleblowing policies in their Statement of Corporate Governance section, established whistleblowing policies, and mentioned the importance of whistleblowing activities within sections in their annual reports. This study focuses on companies’ annual reports. Future studies could be conducted to assess whistleblowing disclosure in other mediums such as the official websites of the companies. The study explored the aspect of corporate governance for the employee as practiced within publicly listed companies in Malaysia. The findings revealed the companies’ best practices for promoting transparency and accountability within organizations.
Physical Module Validation Integrating Creative Thinking Ability in Measurement and Movement Materials
Authors: Hafizah Nisaul , Hufri Hufri 
Published: October 2023

The demands of the world of the future require children to have the creative thinking skills needed to develop science, technology and art. The chosen approach was to create a Physics learning module that incorporates students' creative thinking skills. The research conducted included the type of research and development and the object of the research was the Physics Module which was tested on high school class X students. This demonstrate employments 4 stages, specifically defining, designing, developing, and disseminating. Based on the comes about of the investigate that has been done, it can be concluded that the Physics Module integrates the ability to think creatively in the measurement and motion material that has been developed has a validity value of 71 in the valid category
The Implementation of a Generative Learning Model With Contextual Approach Toward Physics Learning Outcomes
Authors: Parni Nurul Hasanah , Akmam Akmam 
Published: October 2023

Learning is an interactive process among students to accomplish the educational outcome. The problem occurring is that the students give few participations in during the learning process, since they only listen to the teachers, as a result, they are not able to develop their own knowledge so the learning outcome is low. The solution offered to improve the learning outcome is implement generative learning model which is based on contextual approach. The goal of the study is to discover the impact of generative learning model based on contextual approach toward the results of students learning about dynamic fluid material in the second grade of High School 13 Padang particularly science students. This is a quasi experiment research with Post-test Only Control Design. The population of this research is science students of High School number 13 Padang in the year of 2022/2023. The technique used to achieve data is Purposive Sampling. The sample is XI Science 1 students as experiment class and XI Science 3 as control group. The instrument applied is written test in form of multiple questions. Data analysis was done by mean similarity test. The result showed a significant variation between students learning outcome from the group which utilized generative learning model PBL. The average of student’s learning outcome in experiment group is 73.14 and control group PBL is 69.83. Based on the equality test two averages are obtained tcount 9.70 and ttable=1.995 in significant level alfa = 0,05. The H0 requirement refused is if ttable < tcount. The mark of tcount is in the denial of H0 hereby Hi is received. It proves that generative learning model based on contextual approach affected students learning outcome.
Content of photosynthetic pigments in Phragmites communis (Cav.) Trin. ex Steud., Salvinia natans L. (All.), Utricularia vulgaris L. and Ceratophyllum demersum L. during the season in the area of the Bardača pond (Republika Srpska)
Authors: Maksimović Tanja , Lolić Svjetlana , Kukavica Biljana 
Published: October 2023

Abstract
It is known that aquatic macrophytes are an important part of freshwater ecosystems, and that they play a different role in their structure and functioning. Their presence and distribution depends on water temperature and transparency, nutrient content, conductivity, pH, chemical composition and water circulation. Therefore, the goal of our research was to determine the influence and interrelationship of physicochemical parameters of water on the content of photosynthetic pigments in aquatic macrophytes of Lake Necik, in the Ramsar area of Bardača (Republic of Srpska). Content of total chlorophyll (a + b) during the growing season (June–October) ranged from 0.231 to 1.145 mg g−1 FW in Phragmites communis Trin. ex Steud., from 0.061 to 0.541 mg g−1 FW in Salvinia natans L. (All.), from 0.063 to 0.626 mg g−1 FW in Utricularia vulgaris L. and from 0.063 to 0.443 mg g−1 FW in Ceratophyllum demersum L. Research has shown that floating and submerged macrophytes have a lower ratio of chlorophyll a/b compared to emergent hydrophytes, which is most likely the result of stress caused by increased light intensity and temperature. Seasonal variations in the content of photosynthetic pigments indicated that the species Phragmites communis proved to be more tolerant to the stress caused by the influence of various abiotic factors, while Salvinia natans proved to be more sensitive. Spearmon’s correlation coefficient of the physicochemical parameters of water and the concentration of photosynthetic pigments of macrophytes showed a significant influence of certain abiotic factors (temperature, transparency and nutrients) on the content of pigments in the leaves of Phragmites communis, Salvinia natans, Utricularia vulgaris and Ceratophyllum demersum L.
Population dynamics and wintering behavior of the black–headed gull Chroicocephalus ridibundus at El Mellah lagoon (Northeastern Algeria)
Authors: Boukhari Chaima , Lazli Amel , Nouri Nada , Benmetir Sarra , Soltani Roumaissa , Beldi Moncef , Nebbache Madjid 
Published: October 2023

Abstract
The population dynamics and behavior of the black-headed gull of an Algerian coastal wetland, El Mellah lagoon (Lake Mellah), were studied during three consecutive wintering seasons (2018–2021). Maximum numbers of the species were counted in December and January depending on the year. A peak of 536 individuals was recorded in the first half of December 2018, another of 538 individuals in the second half of December 2019, and a final peak of 636 birds in the first half of January 2021. Diurnal activity patterns showed that feeding was the primary behavior, with a mean of 24% for the three seasons. It was followed by sleeping (21%), swimming (19%), preening (18%), and flight (17%). Black-headed gulls appeared to be more active in the morning than at other times of the day.
This study attempts to provide recent and unpublished data on the wintering and behavior of the black-headed gull, which remains poorly documented in North Africa and particularly in Algeria, and highlights the patterns of wetland use by these species, which could help to evaluate the importance of certain areas and develop management plans specific to coastal habitats and their avifaunal diversity.
PENYULUHAN SANITASI LINGKUNGAN DI KAMPUNG NELAYAN MACCINI BAJI KELURAHAN PUNDATA BAJI KABUPATEN PANGKAJENE KEPULAUAN
Authors: Manyullei S. , Mustafa I. , Bahtiar L.O. , , Nurhikmah 
Published: October 2023

Sanitasi lingkungan menjadi tantangan yang berat bagi Kampung Nelayan Maccini Baji Kelurahan Pundata Baji Kabupaten Pangkajene dan Kepulauan karena berada di pesisir dengan kondisi tergenang air dibawah rumah. Dilakukan pengabdian masyarakat berupa penyuluhan sanitasi lingkungan dengan tujuan untuk mengetahui pengaruh penyuluhan sanitasi lingkungan terhadap pengetahuan masyarakat Kampung Nelayan Maccini Baji Kelurahan Pundata Baji Kabupaten Pangkajene dan Kepulauan tahun 2022. Metode yang digunakan, yaitu ceramah dan diskusi dengan desain one group pretest – posttest menggunaka media lembar balik. Hasil analisa data nilai rata-rata pengetahuan masyarakat sebelum diberikan penyuluhan kesehatan yaitu 47,89 dan sesudah penyuluhan kesehatan, nilai rata-rata pengetahuan masyarakat meningkat menjadi 61,68. Sehingga terdapat perbedaan pengetahuan masyarakat sebelum dan sesudah dilakukan penyuluhan.Dari hasil uji Wilcoxon Signed Rank Test diperoleh nilai ?-value 0,003 < 0,05, maka Ho ditolak, yang artinya terdapat pengaruh penyuluhan sanitasi lingkungan kepada masyarakat di Kampung Nelayan Kelurahan Pundata Baji Kabupaten Pangkajene Kepulauan tahun 2022. Oleh karena itu, perbaikan sanitasi lingkungan sangat penting untuk meminimalkan dampak kesehatan yang ditimbulkan sebagai upaya meningkatkan derajat kesehatan masyarakat.
Kata kunci : Penyuluhan, Sanitasi, Lingkungan, Kampung Nelayan.
PEMERIKSAAN WAKTU REAKSI VISUAL DAN SOSIALISASI PERILAKU SEDENTARI PADA SISWA SEKOLAH DASAR NEGERI 2 SUMERTA DENPASAR TIMUR
Authors: K.A.J. Antari N. , Nugraha M.H.S. , Winaya I.M.N. , Dewi A.A.N.T.N. , Andayani N.L.N. 
Published: October 2023

Kebiasaan dari kurangnya melakukan aktivitas sehari hari sering dikategorikan sebagai perilaku sedentari yang mana perilaku sedentari ini dikatakan memberikan dampak buruk bagi anak. Salah satu dampak yang muncul dari aktivitas sedentari adalah menurunnya waktu reaksi anak. Waktu reaksi diartikan sebagai waktu yang dibutuhkan untuk munculnya suatu respon yang diinginkan dari mulai diterimanya stimulus hingga. Kecepatan reaksi visual dikatkan dengan kecepatan anak dalam membaca, yang diawali dari input sensoris dalam bentuk huruf dilanjutkan dengan mengintepretasikan input visual tersebut hingga terbentuk sebuah respon berupa pengucapan bentuk huruf dengan tepat. Tujuan dari pelaksanaan pengabdian ini adalah untuk memberika sosialisasi dampak perilaku sedentari dan pemeriksaan waktu reaksi visual pada anak sekolah dasar. Target khusus yang ingin dicapai dari kegiatan ini adalah dengan mengetahui dampak dari perilaku sedentari diharapkan orang tua dan pihak sekolah memberikan kegiatan berupa aktivitas fisik yang juga dapat melatih waktu reaksi anak. Berdasarkan pengabdian masyarakat yang telah dilakukan, didapatkan hasil sebagai berikut: (1) Sampel mengikuti pengabdian ini berjumlah 71 orang yang terdiri atas siswa kelas 4 sejumlah 24, siswa kelas 5 sejumlah 17 dansiswa kelas 6 sejumlah 30, (2) Siswa kelas 4 memiliki nilai rata-rata kecepatan waktu reaksi sebesar 533,83ms. Siswa kelas 5 memiliki nilai rata-rata kecepatan waktu reaksi sebesar 513,36ms. Siswa kelas 6 memiliki nilai rata-rata kecepatan waktu reaksi sebesar 492,77ms.
Kata kunci : sosialisasi, perilaku sedentary, waktu reaksi visual