bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adeno‐associated virus‐vectored erythropoietin gene therapy for anemia in cats with chronic kidney disease
Authors: Vaden Shelly L. , Kendall Allison R. , Foster Jonathan D. , New Heidi L. , Eagleson Jane S. , May Jacky L. , Traas Anne M. , Wilson Matthew J. , McIntyre Beth H. , Hinderer Christian J. , Olenick Lauren K. , Wilson James M. 
Published: October 2023

AbstractBackgroundA treatment of chronic kidney disease (CKD)‐associated anemia in cats is needed. SB‐001 is an adeno‐associated virus‐vectored (AAV)‐based gene therapeutic agent that is administered intramuscularly, causing the expression of feline erythropoietin.Hypothesis/ObjectiveWe hypothesized that SB‐001 injection would lead to a sustained increase in PCV in cats with CKD‐associated anemia.AnimalsTwenty‐three cats with International Renal Interest Society (IRIS) Stage 2 to 4 CKD‐associated anemia were enrolled at 4 veterinary clinics.MethodsIn a prospective clinical trial, cats were treated with 1 of 3 regimens of SB‐001 (Lo 1.2 × 109 genome copies [GCs] on Day 0; Lo ± Hi [supplemental 2nd dose of 3.65 × 109 GC on Day 42]; Hi 3.65 × 109 GC IM on Day 0) and followed for 70 days.ResultsA response to SB‐001 at any time between Day 28 and Day 70 was seen in 86% (95% confidence interval 65, 97%) of all cats. There was a significant (P < .003) increase in PCV from Day 0 to Day 28 (mean increase 6 ± 6 percentage points [pp]; n = 21), Day 42 (8 ± 9 pp; n = 21), Day 56 (10 ± 11 pp; n = 17), and Day 70 (13 ± 14 pp, n = 14). Twelve cats were hypertensive at baseline, 4 of which developed encephalopathy during the study. An additional 6 cats became hypertensive during the study.Conclusions and Clinical ImportanceResults of this study suggest that SB‐001 therapy represents a suitable single injection treatment that can address nonregenerative anemia in cats with CKD. It was generally well tolerated; however, hypertension and encephalopathy developed in some cats as previously described in association with erythropoiesis‐stimulating agent therapy.
Mass deportation and the intensity of policing in the United States' 100‐mile border zone: Complicating the “border”/“interior” enforcement binary
Authors: Boyce Geoff 
Published: October 2023

AbstractThis paper draws on an expansive archive of internal government records obtained using the US Freedom of Information Act to examine federal, state and local police practice within the United States' 100‐mile border zone. Analysis of this archive reveals a large number of “border” enforcement events that involve the arrest of US citizens, lawful permanent residents and others with deep roots in US communities. It further shows how, regardless of where US Border Patrol agents operate, those whom they target overwhelmingly tend to be persons of Latin American origin. Reflecting on these enforcement patterns, the paper argues for the troubling of categorical distinctions between “border” and “interior” enforcement that permeates scholarly, popular and journalistic accounts of the contemporary geography of mass deportation in the United States. As an alternative, the paper calls for greater attention to the “intensity” of immigration policing, as a way to account for multiple overlapping pathways of enforcement and to diagnose how the networked interconnectivity of agencies, personnel, resources and infrastructures involved in these activities amplifies the risks of racial profiling, arrest, and a host of related downstream consequences (family separation, financial hardship, diminished educational performance, and adverse health outcomes) for US citizens and noncitizens alike.
Comparing language and religion in normative arguments about linguistic justice
Authors: Boucher François 
Published: October 2023

AbstractMany of the most influential theorists of linguistic justice make arguments on the basis of comparisons between language and religion. They claim either that (1) language, by contrast with religion, cannot be separated from the state or that (2) unequal official linguistic recognition, just like unequal official religious recognition, is morally problematic. This article argues that careful attention to debates about liberalism and the place of religion in public life invites us to question the two above‐mentioned liberal assumptions about religion underlying many arguments concerning linguistic justice based on (dis)analogies between language and religion. The hope is that such critical scrutiny is likely to shed some light on normative questions of linguistic justice, more precisely on questions about the legitimacy of granting more recognition to certain languages, usually those of national native groups (as opposed to groups resulting from more or less recent immigration).
Ralstonia solanacearum pandemic lineage strain UW551 overcomes inhibitory xylem chemistry to break tomato bacterial wilt resistance
Authors: Hamilton Corri D. , Zaricor Beatriz , Dye Carolyn Jean , Dresserl Emma , Michaels Renee , Allen Caitilyn 
Published: October 2023

AbstractPlant‐pathogenic Ralstonia strains cause bacterial wilt disease by colonizing xylem vessels of many crops, including tomato. Host resistance is the best control for bacterial wilt, but resistance mechanisms of the widely used Hawaii 7996 tomato breeding line (H7996) are unknown. Using growth in ex vivo xylem sap as a proxy for host xylem, we found that Ralstonia strain GMI1000 grows in sap from both healthy plants and Ralstonia‐infected susceptible plants. However, sap from Ralstonia‐infected H7996 plants inhibited Ralstonia growth, suggesting that in response to Ralstonia infection, resistant plants increase inhibitors in their xylem sap. Consistent with this, reciprocal grafting and defence gene expression experiments indicated that H7996 wilt resistance acts in both above‐ and belowground plant parts. Concerningly, H7996 resistance is broken by Ralstonia strain UW551 of the pandemic lineage that threatens highland tropical agriculture. Unlike other Ralstonia, UW551 grew well in sap from Ralstonia‐infected H7996 plants. Moreover, other Ralstonia strains could grow in sap from H7996 plants previously infected by UW551. Thus, UW551 overcomes H7996 resistance in part by detoxifying inhibitors in xylem sap. Testing a panel of xylem sap compounds identified by metabolomics revealed that no single chemical differentially inhibits Ralstonia strains that cannot infect H7996. However, sap from Ralstonia‐infected H7996 contained more phenolic compounds, which are known to be involved in plant antimicrobial defence. Culturing UW551 in this sap reduced total phenolic levels, indicating that the resistance‐breaking Ralstonia strain degrades these chemical defences. Together, these results suggest that H7996 tomato wilt resistance depends in part on inducible phenolic compounds in xylem sap.
Apatinib potentiates the therapeutic effect of anti‐PD‐1 in locally advanced head and neck cancers
Authors: Liu Shuli , Zhang Lin , Ye Weimin , Zhou Rong , Gu Ziyue , Shi Chaoji , Xu Shengming , Li Jiang , Zhang Zhiyuan , Han Yong 
Published: October 2023

AbstractObjectivesAntiangiogenic inhibitors have been shown to synergize with immune checkpoint blockade, but the underlying mechanisms of the synergistic response are not fully understood.Patients and MethodsWe investigate the impact of VEGFR2 inhibition on tumor‐infiltrating immune cells in vivo and the activity of the combination of apatinib and anti‐PD‐1 in synergistic mouse model of HNSCC. A patient with squamous cell carcinoma of the left tongue with cervical lymph node were received with combined induction treatment of camrelizumab and apatinib to validate the efficacy of neoadjuvant immunotherapy before surgery.ResultsWe found that apatinib increased the infiltration of CD8+T cells and decreased the population of Tregs in a preclinical syngeneic mouse model. The proportions of CD8+PD1+T cells were significantly increased in apatinib‐treated tumors. The combined treatment of apatinib and anti‐PD‐1 demonstrated better therapeutic benefit than each treatment alone. The patient with squamous cell carcinoma of the left tongue with cervical lymph node achieved major pathologic response (MPR) after two cycles of combined induction treatment.ConclusionOur study demonstrated that apatinib therapy synergized with an anti–PD‐1 antibody in preclinical cancer models and in patient with advanced HNSCC. These results provide a new rationale for advancing this neoadjuvant immunotherapy in large scale of clinical trials of HNSCC.
Clinical characteristics of infantile hemangiomas with aggressive, persistent, and destructive ulceration
Authors: Gautam Ayushi , Frieden Ilona J. , Shah Sonal D. , Witman Patricia M. , Harfmann Katya , Bradley Flora , Blei Francine , Pope Elena , Alsumait Anwar , Gupta Deepti , Covelli Isabela , Streicher Jenna L. , Cotton Colleen , Tollefson Megha , Nguyen Henry , Hunt Raegan , Buros Amy , Fernández Faith Esteban 
Published: October 2023

AbstractBackground/ObjectivesUlceration is a common complication of infantile hemangioma (IH). Severe, persistent ulceration occurs in a minority of patients. This study aims to characterize the clinical features of IH with aggressive ulceration (AU).MethodsMulticenter retrospective study of clinical features of IH with AU.ResultsThirty‐five patients with AU were identified and included in the study. The majority of AU occurred in segmental IH (23/35, 65%). Segmental IH with AU were large (≥10 cm2; 16/23, 69%, p < .001) with a thin (<3 mm) superficial component (16/23, 69%, p < .001). Localized IH with AU had a thick (>3 mm) superficial component (11/12, 92%, p < .001).All diaper area IH with AU (9/35) were segmental with thin superficial component (100%, p = .02). IH with AU in the head/neck (10/35) were more commonly localized (67%) and mixed (62.5%), while segmental, thick superficial morphology was more common on trunk (9/35) and upper extremities (7/35).ConclusionsIH resulting in AU differ in clinical features by anatomic site. Those in the diaper area are nearly always segmental with thin superficial component, whereas other sites tend to be localized, mixed, with thick superficial component. These distinct phenotypes may prove useful in the clinical setting for physicians to identify patterns of IH ulceration with increased risk of aggressive, persistent ulceration.
COVID‐19 associated mucormycosis surge: A review on multi‐pathway mechanisms
Authors: Pourazizi Mohsen , Hakamifard Atousa , Peyman Alireza , Mohammadi Rasoul , Dehghani Shakiba , Tavousi Najmeh , Hosseini Nastaran‐Sadat , Azhdari Tehrani Hamed , Abtahi‐Naeini Bahareh 
Published: October 2023

AbstractMucormycosis is a fungal infection caused by moulds from the Mucorales order. Concerns have been mounting due to the alarming increase in severe morbidity and mortality associated with mucormycosis during the COVID‐19 pandemic. This condition, known as COVID‐19‐associated mucormycosis (CAM), has been linked to various environmental, host‐related, and medical factors on a global scale. We have categorized the most significant potential risk factors for developing mucormycosis in individuals with a previous history of coronavirus infection into 10 major categories. These categories include acute hyperglycemia, the impact of cytokine release, immune response deficiencies in COVID‐19 patients, microvasculopathy and dysfunction of endothelial cells, imbalances in iron metabolism, metabolic acidosis, organ damage resulting from COVID‐19, underlying health conditions (such as diabetes), environmental factors, and medical treatments that can be iatrogenic in nature (such as inappropriate glucocorticoid use). Many of these factors can lead to potentially life‐threatening infections that can complicate the treatment of COVID‐19. Physicians should be vigilant about these factors because early detection of mucormycosis is crucial for effective management of this condition.
Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Authors: Marruganti Crystal , Suvan Jean E. , D'Aiuto Francesco 
Published: October 2023

AbstractNoncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is also rapidly rising. “Multimorbidity,” defined as the presence of two or more long‐term physical or mental disorders, is now considered a worldwide epidemic, affecting around 20% of the adult population. Periodontitis, diabetes, and obesity, all chronic inflammatory diseases, are an example of multimorbidity highly relevant to dental practitioners. Over the last three decades, the three‐way relationship among the diseases has been vastly researched and accepted, with important contributions by European researchers. The interplay among periodontitis, diabetes, and obesity is sustained by shared biological mechanisms, such as systemic inflammation, insulin resistance, and metabolic dysfunction, as well as common lifestyle‐related risk factors. As such, unhealthy lifestyles were found to generally increase systemic inflammation and insulin resistance and decrease immune function, hence, eventually increasing the risk of NCDs onset and the development of multimorbidity. This narrative review of the evidence supports the need for a paradigm shift from a “single‐disease” to a “multiple‐disease” framework, characterized by an integrated multidisciplinary approach, which should include lifestyle modification interventions to successfully tackle multimorbid periodontitis and metabolic diseases (diabetes and obesity). A multidisciplinary integrated care pathway in both dental and medical settings should be considered to further tackle the global health challenge of multimorbidity.
Policy instruments attitudes and support for government responses against Covid‐19
Authors: Veselý Arnošt , Petrúšek Ivan , Soukup Petr 
Published: October 2023

AbstractAn individual's political attitudes have been documented as the most important predictor of acceptance of government measures against the COVID‐19 pandemic. Their effect, however, is somewhat unclear and cannot be reduced to one dimension. In this article, we test whether general attitudes toward policy instruments might, together with left–right orientation, authoritarianism, social liberalism, and attitudes to state intervention, explain attitudes to policy instruments used to combat COVID‐19. The predictiveness of models of attitudes toward three different types of policy instruments to address the COVID‐19 pandemic was tested using a study of Czech university students). We found that individuals' general attitudes toward policy instruments are best measured by posing direct survey questions. Structural equation modeling was used to estimate the independent effects of general attitudes toward three different types of policy instruments on attitudes toward specific policy instruments for combating COVID‐19. We found that an individuals' general tendency to prefer an information, regulatory, or economic instrument significantly affects their attitude toward specific policy solutions, even after controlling for political orientation. These results provide novel empirical evidence for the autonomy of policy instruments attitudes (APIA) theory. The general attitudes toward policy instrument types are reflected in individuals' attitudes toward specific policy instruments, such as those used to combat COVID‐19.
MALDI Mass Spectrometry Imaging and Semi‐Quantification of Topically Delivered Lactic Acid
Authors: Cohen Aaron , Legouffe Raphael , Mao Junhong , Gaudin Mathieu , Bonnel David 
Published: October 2023

AbstractBackgroundLactic acid is a common active ingredient in many topical skincare products; however, measuring its delivery into the skin is challenging due to the presence of a large level of endogenous lactic acid. In this study, matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) was used to quantitatively and qualitatively measure the delivery of lactic acid into the skin from a range of topical skincare products.Materials and methodsPorcine skin samples were treated with various skincare products containing lactic acid. After 24 h, skin samples were sectioned and treated via H&E staining or prepared for MALDI‐MSI using chemical derivatization. Samples were then analyzed by MALDI‐MSI imaging to obtain lactic acid distribution in the entire skin section.ResultsDue to the high level of endogenous lactic acid in the skin, a “triple isotope” of lactic acid (L‐Lactic acid‐13C3), was needed to provide full resolution from the skin's background signal with MALDI‐MSI. With this approach, the topically delivered lactic acid could be quantitatively and qualitatively analyzed from a variety of skincare products.ConclusionsThe combination of L‐Lactic acid‐13C3 and MALDI‐MSI was successfully used to quantitatively and qualitatively measure the topical delivery of lactic acid from a variety of skincare products. This approach could be used in future work to better understand the mode of action of lactic acid as an active ingredient in skincare products.
Phylogenetic reconstruction of Corydioidea (Dictyoptera: Blattodea) provides new insights on the placement of Latindiinae and supports the proposal of the new subfamily Ctenoneurinae
Authors: Han Wei , Qiu Lu , Zhang Jiawei , Wang Zongqing , Che Yanli 
Published: October 2023

AbstractRepresentatives of the cockroach superfamily Corydioidea are less sampled than members of the two other cockroach superfamilies (Blaberoidea and Blattoidea) due to the difficulty of collecting them in the field, accentuated by a general lack of knowledge on their biology. Their evolutionary relationships have not yet been investigated with a relevant sampling and are therefore poorly known. Here, we assess the phylogenetic relationships of 35 Corydioidea species with mitochondrial genomes and two nuclear gene fragments. Our sampling for Corydiidae comprises Corydiinae and Euthyrrhaphinae representatives, whereas our sampling for the remaining Corydioidea includes species belonging to genera Beybienkonus Qiu, Wang and Che, Compsodes Hebard, Ctenoneura Hanitsch and Nocticola Bolívar. We further infer their divergence times with molecular dating analyses relying on five fossil calibrations. We also carry out reconstructions of ancestral character states for 11 phenotypic and one biological traits. Our results recover two major Corydioidea clades, one consisting solely of Corydiidae (except Latindiinae) and the other of all remaining Corydioidea taxa. Based on the results of phylogenetic analyses, an updated classification of extant Corydioidea is proposed, where Latindiinae Handlirsch stat.rev. and Ctenoneurinae Qiu and Che, subfam.nov. are assigned to the family Nocticolidae Bolívar sensu nov. A new genus Pseudoeupolyphaga Qiu and Che, gen.nov. is also established within Corydiinae. Both the origin of crown Corydioidea and the divergence of the two major lineages are estimated to have occurred during the Triassic–Jurassic boundary. Ancestral character state reconstruction analyses also suggest an adaptive relationship between phenotypic characteristics and habitat preferences.
Copper‐independent lysosomal localisation of the Wilson disease protein ATP7B
Authors: Maji Saptarshi , Pirozzi Marinella , Ruturaj  , Pandey Raviranjan , Ghosh Tamal , Das Santanu , Gupta Arnab 
Published: October 2023

AbstractIn hepatocytes, the Wilson disease protein ATP7B resides on the trans‐Golgi network (TGN) and traffics to peripheral lysosomes to export excess intracellular copper through lysosomal exocytosis. We found that in basal copper or even upon copper chelation, a significant amount of ATP7B persists in the endolysosomal compartment of hepatocytes but not in non‐hepatic cells. These ATP7B‐harbouring lysosomes lie in close proximity of ~10 nm to the TGN. ATP7B constitutively distributes itself between the sub‐domain of the TGN with a lower pH and the TGN‐proximal lysosomal compartments. The presence of ATP7B on TGN‐lysosome colocalising sites upon Golgi disruption suggested a possible exchange of ATP7B directly between the TGN and its proximal lysosomes. Manipulating lysosomal positioning significantly alters the localisation of ATP7B in the cell. Contrary to previous understanding, we found that upon copper chelation in a copper‐replete hepatocyte, ATP7B is not retrieved back to TGN from peripheral lysosomes; rather, ATP7B recycles to these TGN‐proximal lysosomes to initiate the next cycle of copper transport. We report a hitherto unknown copper‐independent lysosomal localisation of ATP7B and the importance of TGN‐proximal lysosomes but not TGN as the terminal acceptor organelle of ATP7B in its retrograde pathway.
Trilemma revisited with dollar dominance in trade and finance
Authors: Dovonou Vanessa Olakemi 
Published: October 2023

AbstractThis paper explores the impact of the US dollar dominance on monetary and exchange rate policies in 51 advanced and developing countries from 1999 to 2021. We introduce a global exposure index to measure countries' dependence on the US dollar. Our study reveals that the dominant currency framework creates a global monetary cycle driven by the US dollar, exposing non‐U.S. economies to the U.S. monetary policy. However, we show that countries can reduce their exposure to the U.S. monetary policy by accumulating reserves and intervening in foreign exchange.
THE QURʾĀN AND SCIENCE, PART III: MAKERS OF THE SCIENTIFIC MIRACULOUSNESS
Authors: Daneshgar Majid 
Published: October 2023

AbstractThe last article of this three‐part series on the Qurʾān and science discusses the creation and development of the scientific miraculousness of the Qurʾān, which claims that the Qurʾān contains scientific findings and has particular scientific features, such as harmonious numerical analogies and formulae, that confirm the divine origin of the text. It became a political‐theological tool used by Muslim preachers and activists across the globe. Unlike scientific interpreters of the Qurʾān, advocates of scientific miraculousness were concerned with not only uniting Muslims and proving God's authority over the universe but also promoting the Qurʾān as a mine of modern science, archaeology, and history, the authenticity of which is unchallengeable.
Random generation of associative algebras
Authors: Sercombe Damian , Shalev Aner 
Published: October 2023

AbstractThere has been considerable interest in recent decades in questions of random generation of finite and profinite groups and finite simple groups in particular. In this paper, we study similar notions for finite and profinite associative algebras. Let be a finite field. Let be a finite‐dimensional, associative, unital algebra over . Let be the probability that two elements of chosen (uniformly and independently) at random will generate as a unital ‐algebra. It is known that if is simple, then as . We extend this result to a large class of finite associative algebras. For simple, we find the optimal lower bound for and we estimate the growth rate of in terms of the minimal index of any proper subalgebra of . We also study the random generation of simple algebras by two elements that have a given characteristic polynomial (resp. a given rank). In addition, we bound above and below the minimal number of generators of general finite algebras. Finally, we let be a profinite algebra over . We show that is positively finitely generated if and only if has polynomial maximal subalgebra growth. Related quantitative results are also established.