bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes
Authors: Lazrek Amina , Finocchi Ghersi Sebastiano , Petre Adeline , Houabes Sarah , Serre Anne-Agathe , Gassa Frederic , Sandt Magali , Laude Cecile , Roukoz Camille , Cozzi Salvatore 
Published: January 2025

IntroductionProstate cancer remains a prevalent malignancy among men, often necessitating innovative therapeutic strategies for effective management of recurrent cases. This article examines the critical role of a biodegradable hydrogel spacer, which creates a temporary interspace between the prostate and the rectum, thus reducing radiation exposure to healthy tissues.Case descriptionWe present a case of a man with a history of intermediate-risk prostate adenocarcinoma initially treated with external beam radiotherapy in 2015. Despite initial remission, the patient experienced a rise in prostate-specific antigen (PSA) levels indicative of local recurrence in 2022. Salvage treatment with iodine-125 brachytherapy, preceded by the placement of a rectal spacer in January 2024, resulted in a significant reduction of PSA levels. The patient remains asymptomatic with no urinary or gastrointestinal complications 6 months after the salvage treatment.DiscussionThis case illustrates the complexities in managing recurrent prostate cancer and the evolving role of reirradiation strategies. Salvage iodine-125 brachytherapy with the placement of a rectal spacer provided precise radiation delivery while minimizing rectal toxicities. The significant biochemical response observed underscores the efficacy of this approach in controlling disease progression. The rectal spacer enhances treatment safety by reducing radiation exposure to adjacent tissues, highlighting its importance in reirradiation protocols. This case contributes to the growing evidence supporting the rectal spacer’s role in enhancing the safety and efficacy of salvage brachytherapy for recurrent prostate cancer.ConclusionsOur experience advocates for the integration of a hydrogel rectal spacer as a valuable tool in prostate cancer reirradiation protocols, offering a strategic approach to optimize treatment safety by minimizing rectal toxicity.
Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer
Authors: Gaudian Kelly , Koh Min Jung , Koh Min Ji , Collins Ryan R. , Eden Shaine , Zwart Zoya , Danner Malika , Zwart Alan , Fallick Mark , Kumar Deepak , Leger Paul , Dawson Nancy A. , Suy Simeng , Collins Sean P. 
Published: January 2025

IntroductionInjectable GnRH receptor agonists have been shown to improve cancer control when combined with radiotherapy (RT). Relugolix is an oral GnRH receptor antagonist that achieves rapid testosterone suppression. Non-adherence to oral medications due to poor social support or bothersome side effects may increase the risk of cancer recurrence. This prospective study sought to evaluate early testosterone suppression and relugolix drug adherence when combined with prostate stereotactic body radiation therapy (SBRT). Utilization of patient-reported outcomes (PROs) to assess oral medication adherence and guide intervention may improve the appropriate utilization of oral medications. This study focuses on the use of the Simplified Medication Adherence Questionnaire (SMAQ) as a tool to assess relugolix adherence.MethodsRelugolix was initiated at least 2 months prior to questionnaire administration. Adherence was assessed using the SMAQ. Total testosterone levels were obtained at the time of SMAQ administration. Castration was defined as serum testosterone ≤ 50 ng/dL. Poor drug adherence was delineated as failure to reach castration or non-adherence per the SMAQ (any non-adherence answer, missed &gt; 2 doses in last week or since last visit). To compare the demographic and clinical characteristics of patients who adhered to treatment versus who did not, t-test, Wilcoxon rank sum test, Chi-square test, and Fisher’s exact test were used. A p-value &lt; 0.05 determined statistical significance.ResultsBetween August 2021 and December 2023, 78 men were treated at Georgetown with relugolix and prostate SBRT per an institutional protocol. The median age was 72, and 41% of patients were non-white. Patients initiated relugolix at a median of 4 months prior to the SMAQ (2-19 months). 96% of patients achieved castration (≤ 50 ng/dL) at the time of the SMAQ. 96% of men reported always taking relugolix at the appropriate time. 1% discontinued medication due to bothersome side effects, 17% reported forgetting to take the medication, and 4% reported missing a dose during the weekend. 98% and 93% did not miss a dose more than 2 times in the last week and since the last visit, respectively. Overall patient-reported drug adherence was 75%. No patient demographic or clinical characteristic predicted non-adherence.DiscussionRelugolix allows for high rates of castration and drug adherence when combined with prostate SBRT. Monitoring drug adherence during treatment allows for prompt detection of non-adherence and timely intervention. Future studies should focus on how to optimally incorporate this questionnaire into patient management.
The association between the site of back pain and number of painful sites with daily activities, seeking healthcare, and medication use among school adolescents
Authors: Gonçalves Tatiana Rehder , Mediano Mauro Felippe Felix , Sichieri Rosely , Cunha Diana Barbosa 
Published: January 2025

IntroductionThe potential consequences of back pain (BP) are poorly described in adolescents. This study evaluated the association between BP sites (neck, thoracic and low back) and number of painful sites with missed school classes, interference in physical activities, seeking healthcare, and medication use among school adolescents.MethodsThis cross-sectional study included 350 students (5th to 9th grade) of a public school in Brazil. Information on BP site and outcomes were self-reported. Logistic regression analyses were performed.ResultsParticipants reporting at least one painful site in spine were 74.9% (n = 262), with mean age of 12.73 ± 1.67 (55.7% were girls). Most of them reported pain in two sites (n = 100; 28.6%) and the most frequent pain site was neck (n = 223; 63.7%). Thoracic and low BP were associated with missing school classes, interference in physical activities, seeking healthcare, and medication use, while neck pain showed no association. The number of painful sites was associated with daily activities and healthcare with those gradients increasing with the number of painful sites.ConclusionThoracic and low BP were associated with daily activities, seeking healthcare, and medication use in early adolescence.
Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized controlled trial
Authors: Wang Chenhui , Yan Mengwei , Li Yuru , Han Lei , Wang Hongqian , Jia Shufeng , Liu Xingchen , Liu Yang , Wu Fan , Wang Baoguo 
Published: January 2025

ObjectiveKnee osteoarthritis (KOA) is a degenerative joint condition, leading to disability and diminished quality of life. Molecular hydrogen has been proven to have antioxidant and anti-inflammatory properties, but few studies have investigated its effects on osteoarthritis. Our study aims to assess the therapeutic potential of hydrogen-oxygen mixture (H2-O2) inhalation for KOA.MethodsIn this randomized controlled trial, eligible elderly KOA patients were randomly assigned to either Group H or Group C. Both groups participated in a 12-week home-based exercise (HBE) program, which included knee-joint exercises and health education. Group H additionally received H2-O2 inhalation for 60 min per day over 2 weeks, while Group C did not. The primary outcome was measured using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcomes included inflammation levels (hs-CRP, NLR, PLR, LMR), Chair Stand Test (CST), Timed Up and Go (TUG), 36-item short-form health survey (SF-36), Exercise Adherence Rating Scale (EARS), and adverse events.ResultsA total of 121 subjects were enrolled, with an average age of 81.2 years, and 80.2% were female. The between-group mean difference in the WOMAC total score was −5.2 (95% CI −12.1 to 1.7, P = 0.140) at week 12, with Group H showing an improvement of −22.9 (95% CI −26.3 to −19.6, P &lt; 0.001) and Group C showing an improvement of −19.4 (95% CI −22.7 to −16.0, P &lt; 0.001) compared to baseline, revealing a significant group × time interaction (F (3, 356.034) = 14.425, P &lt; 0.001). No significant differences were observed between both groups at week 12 in CST, TUG, SF-36 scores, EARS scores, or the incidence of adverse events.ConclusionAlthough clinical significance was not achieved, H2-O2 inhalation alleviated KOA symptoms and enhanced functional activity in elderly patients undergoing the HBE program during the initial 2 weeks. However, its sustained effects on improving KOA symptoms were not observed.
The BASIDIN effector of the fungus Moniliophthora perniciosa promotes positive effects on the seed germination and seedlings development of Lactuca sativa
Authors: Farias Keilane Silva , Ferreira Monaliza Macêdo , De Oliveira Ivina Barbosa , Dalio Ronaldo José Durigan , Pirovani Carlos Priminho 
Published: January 2025

Plant resistance inducers that activate plant defense mechanisms may be useful in reducing agrotoxic use. Lettuce is among the most economically important leafy vegetable crops in the world. Since lettuce propagates through seeds, the use of high-quality seeds is extremely important for establishing the crop. Several studies have demonstrated the potential of alternative methods of seed treatment with the aim of increasing productivity. Based on this premise, we tested the effect of the rBASIDIN effector regarding its ability to induce germination and physiological changes in lettuce seedlings through seed treatment. The seeds were treated for 30 min by soaking with 50 µg mL-1, 75 µg mL-1 and 100 µg mL-1 of the recombinant effector protein rBASIDIN. Seeds treated with distilled water and 10 mmol of Tris-HCl served as controls. The physiological parameters evaluated were germination percentage at 4 and 7 days, seedling length (aerial part and root), dry and fresh mass, electrical conductivity, and enzymatic activity. Seeds treated with 50 and 75 µg mL-1 of rBASIDIN germinated earlier than the controls. Treatment with rBASIDIN at a concentration of 50 µg mL-1 resulted in seedlings with an average root length of 1.51 cm, while the average lengths of the controls (H2O and buffer) were 0.86 and 0.70 cm respectively. Seed treatment with rBASIDIN caused an increase in the fresh and dry weight of the plants. The lowest electrolyte leakage was detected in seeds treated with the three concentrations of rBASIDIN compared to the controls. Regarding the activity of defense enzymes, seedlings treated with rBASIDIN at lower concentrations showed higher chitinase and β-glucanase activity compared to the controls. The results indicated that the rBASIDIN effector plays an important signaling role in lettuce seeds, since small doses are already sufficient to induce changes in physiological parameters to obtain more vigorous plants.
Hoarding knowledge or hoarding stress? Investigating the link between digital hoarding and cognitive failures among Chinese college students
Authors: Liu Yan , Liu Yaorong 
Published: January 2025

IntroductionDigital hoarding is defined as the persistent accumulation of digital content and an unwillingness to delete it. This behavior has been found to be particularly prevalent among young people. This study aims to explore the impact of digital hoarding on cognitive failures, examining fatigue as a mediator and mindfulness as a moderator.MethodA total of 801 participants were recruited to complete a survey that contained measures of digital hoarding, fatigue, mindfulness, and cognitive failures. The hypothesized moderated mediation model was tested using Models 4 and 8 from the PROCESS macro in SPSS.Results(1) Digital hoarding positively predicted cognitive failures. (2) Fatigue mediated the relationship between digital hoarding and cognitive failures. (3) Mindfulness moderated both the direct effect of digital hoarding on cognitive failures and the first segment of the mediating role of fatigue.DiscussionThis study contributes to a deeper understanding of digital hoarding. It also highlights the great potential of mindfulness in mitigating the negative effects of digital hoarding, and provides students with practical strategies for developing healthier and more balanced digital habits.
Exploring the influence of situational interest on outdoor tourists’ hedonic and eudaimonic well-being
Authors: Xu Peng 
Published: January 2025

IntroductionThis study introduces situational interest as a new factor influencing both hedonic and eudaimonic well-being in outdoor tourism settings. It explores how different dimensions of situational interest drive well-being and the mediation mechanisms involved.MethodsData were collected from 642 respondents through an online self-report questionnaire on the Credamo platform. Structural equation modeling was used to analyze the relationships between situational interest dimensions, well-being outcomes, and mediating factors.ResultsThe results show that instant enjoyment directly enhances hedonic well-being. Novelty has a direct effect on hedonic well-being and an indirect effect on eudaimonic well-being. Attention demand influences hedonic well-being both directly and indirectly. Challenge and exploration intention indirectly promote eudaimonic well-being through the satisfaction of autonomy needs.DiscussionBy uncovering the distinct pathways through which situational interest affects well-being, this study deepens our understanding of how outdoor tourism experiences can foster both immediate enjoyment and long-term personal growth. These findings provide practical insights for designing tourism activities that enhance tourists’ overall well-being.
“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions
Authors: Zirnsak Tessa-May , McCarter Kristen , McKinlay Melissa L. , Guillaumier Ashleigh , Cocks Nadine , Brasier Catherine , Hayes Laura , Baker Amanda L. , Baird Donita E. , Bonevski Billie , Borland Ron , Castle David , Forbes Erin , Kelly Peter J. , Segan Catherine , Sweeney Rohan , Turner Alyna , Williams Jill M. , Brophy Lisa 
Published: January 2025

BackgroundMental health service users are more likely to smoke tobacco and are as likely to make quit attempts as people not experiencing SMI, but they are less likely to succeed. Quitting tobacco can be harder for people experiencing SMI due to higher levels of nicotine dependence, more severe withdrawal, and many other complex factors. The Quitlink study was a randomized controlled trial combining a tailored 8-week Quitline intervention delivered by dedicated Quitline counsellors plus combination nicotine replacement therapy for people who experience SMI. The purpose of this paper is to report on the medium- and longer-term findings from interviews conducted at 5 and 8 months.MethodsAs a part of the broader Quitlink study, participants were invited to qualitative interviews at 2, 5 and 8 months following recruitment, in line with quantitative follow-up time points. Interviews were conducted with 28 participants in the Quitlink trial (intervention group n = 12, control group n = 16). Interviews were transcribed and analyzed with a thematic analysis methodology using NVivo 12. Key themes were determined using inductive coding.ResultsSix key themes were identified. These included: internal/external attributions for tobacco smoking, social relationships and relapse, the role of hopefulness in quitting, the role of clinicians in initiating and maintaining a quit attempt, increasing cessation literacy, and efficacy of the study intervention. Overall, findings suggested that participants’ quit attempts were often precarious and vulnerable, but active support and feelings of social connectedness were key to supporting participants to initiate a quit attempt and maintain gains.ConclusionsPeople who experience SMI can make attempts to quit smoking tobacco with support from clinicians and social networks. Connectedness and hope are significant enablers of making and sustaining quit attempts.Trial registrationThe Quitlink trial was registered with ANZCTR (www.anzctr.org.au): ACTRN12619000244101 prior to the accrual of the first participant and updated regularly as per registry guidelines.
Premonitory urge in tic disorders – a scoping review
Authors: Wohlgemuth John B. , Watson Kelly H. , Gill Kayce D. , Isaacs David A. 
Published: January 2025

IntroductionPremonitory urges are uncomfortable bodily sensations preceding tics. They are highly prevalent, frequently bothersome, and increasingly recognized as a central phenotypic feature in tic disorder populations. This scoping review aimed to systematically consolidate published knowledge and identify knowledge gaps regarding premonitory urges in primary tic disorders.MethodsSearch strategies were deployed in five databases and five topic-relevant journals. Two independent reviewers screened all candidate abstracts against predefined inclusion criteria. One hundred and fifty-five articles were included in the scoping review. The same two reviewers independently extracted and consolidated pertinent data from included articles.ResultsMultiple methods for assessing premonitory urge were identified, each with strengths and weaknesses. The subjective quality of premonitory urges varies between individuals, with increased prevalence of a “not just right” urge quality in individuals with comorbid obsessive-compulsive disorder. Awareness of premonitory urge appears to arise several years after tic-onset, yet many individuals perceive their tics as voluntary responses to premonitory urges. Premonitory urges and tics are temporally coupled in real time, but premonitory urge severity and tic severity, as assessed by clinical scales, are not consistently associated. The mechanistic and developmental relationship between premonitory urges and tics remains unclear. Data are limited on premonitory urge response to treatment, but several promising interventions were identified. The insula and supplementary motor area are the neuroanatomical structures most strongly implicated in emergence of the premonitory urge.DiscussionKnowledge of the clinical characteristics, measurement, and neural mechanisms of premonitory urge has advanced considerably in recent years, but important knowledge gaps remain in each of these domains. Addressing these knowledge gaps will be key to developing effective interventions for premonitory urge.Systematic Review RegistrationOpen Science Framework (OSF) https://doi.org/10.17605/OSF.IO/WT43Z.
Double burden of malnutrition among households in Ethiopia: a systematic review and meta-analysis
Authors: Belay Mahider Awoke , Bogale Eyob Ketema , Haile Mitiku Tefera , Bogale Solomon Ketema , Getachew Eyob , Andarge Getnet Alemu , Seid Kedir , Lakew Gebeyehu , Yirsaw Amlaku Nigusie , Gebreegziabher Zenebe Abebe , Semagn Birhan Ewunu , Alemu Ayenew Takele 
Published: January 2025

IntroductionThe double burden of malnutrition (DBM) at the household level has increased in sub-Saharan African countries as a result of rapid changes in global food systems and growing urbanization. The presence of overweight or obese mothers with undernourished (stunted, wasted, or underweight) children within the same household holds particular significance. However, no comprehensive study or meta-analysis has been conducted to summarize the national evidence of the double burden of malnutrition in mother–child pairs. Therefore, the purpose of this study was to determine the pooled prevalence of the double burden of malnutrition at the household level in Ethiopia in 2024.MethodsThis systematic review and meta-analysis was conducted on the prevalence of the double burden of malnutrition and associated factors among households in Ethiopia, using an advanced search of electronic databases and search engines. The standardized Joanna Briggs Institute (JBI) method was used to extract data from a Microsoft Excel spreadsheet and evaluate the quality of each article. The analysis was performed using STATA V.17. A random-effects model was used to conduct the meta-analysis. Heterogeneity was assessed using the I2 and Q tests.ResultsA total of seven publications met the inclusion criteria, including data from 56,877 and 43,770 mother–child pairs for the systematic review and meta-analysis, respectively. The pooled prevalence of the double burden of malnutrition among the mother–child pairs was 8.30% (95% confidence interval (CI): 1.51, 15.09). The heterogeneity test revealed extremely high heterogeneity (I2 = 99.91%; p = 0.00). In the subgroup analysis based on sample size, the pooled estimated prevalence of the double burden of malnutrition was high for a sample size of fewer than 1,000 mother–child pairs (11.69% (95% CI: 3.11, 20.28)). The pooled estimate from the subgroup analysis of the data collected 8 years ago was 8.61% (95% CI: 1.11, 22.33). Residence, household size, housing quality, wealth index, household food security status, mother’s age and educational status, and child’s age are some of the factors that influence the double burden of malnutrition among mother–child pairs.ConclusionIn Ethiopia, the double burden of malnutrition among mother–child pairs is rapidly emerging. As a result, double-duty interventions should be implemented to address this issue, taking into account multiple factors at the household level.Systematic review registrationThe protocol for the systematic review and meta-analysis was registered under the registration ID CRD42024517778 with the PROSPERO (International Prospective Register of Systematic Review and Meta-analysis).
Eye health risks associated with unclean fuel: a meta-analysis and systematic review
Authors: Chen Shi-Hang , Tang Yuan , Xue Song 
Published: January 2025

PurposeThis study comprehensively examined the correlation between unclean cooking fuels (UCF) and ocular health, covering diverse eye conditions such as cataracts, visual impairments, and ocular discomfort.MethodsAccording to MOOSE and PRISMA guidelines, a meta-analysis and systematic review was conducted on 28 studies from 3 databases. Literature quality was assessed using the Newcastle-Ottawa Scale. Heterogeneity among articles was gaged with the I2 statistic, sensitivity analysis used ‘leave-one-out test’, and publication bias was evaluated using Egger, Begg tests, and funnel plot analysis.ResultsThe study evidenced a significant association between UCF exposure and cataracts [OR 2.29, 95% CI (1.24, 4.23)], visual impairments [OR 1.70, 95% CI (1.45, 2.00)], and eye diseases/symptoms [OR 2.03, 95% CI (1.25, 3.29)]. However, no correlation was found between UCF exposure and glaucoma or elevated intraocular pressure [OR 0.96, 95% CI (0.84, 1.10), n = 2]. Subgroup analysis revealed that UCF cooking had an impact on nuclear cataracts [OR 1.98, 95% CI (1.67, 2.33), n = 4]. But not on cortical cataracts [OR 1.25, 95% CI (0.98, 1.60), n = 3]. Additionally, UCF exposure was linked to severe visual impairments like night blindness [OR 2.03, 95% CI (1.00, 4.96)], blindness [OR 1.43, 95% CI (1.32, 1.55)], and specific ocular symptoms such as tearing while cooking (OR = 3.20), eye irritation (OR = 2.58), and red eyes (OR = 2.03).ConclusionUCF cooking had significant impact on ocular health, notably on eye symptoms, cataracts, and visual impairments. UCF exposure presented demographic inequalities in cataract prevalence, while eye symptoms can serve as a reliable self-assessment of UCF exposure.