bluuebunny/crossref_metadata_2025_split huggingface dataset:
A framework to support teacher noticing of students' mathematical thinking in technology‐mediated environments
Authors: McCulloch Allison W. , Dick Lara K. , Lovett Jennifer N. 
Published: October 2023

AbstractThe practice of teacher noticing students' mathematical thinking often includes three interrelated components: attending to students' strategies, interpreting students' understandings, and deciding how to respond on the basis of students' understanding. This practice gains complexity in technology‐mediated environments (i.e., using technology‐enhanced math tasks) because it requires attending to and interpreting students' engagement with technology. Current frameworks implicitly assume the practice includes noticing the ways students use tools (including technology tools) in their work, but do not explicitly highlight the role of the tool. While research has shown that using these frameworks supports preservice secondary mathematics teachers (PSTs) developing noticing practices, it has also shown that PSTs largely overlook students' technology engagement when they are working on technology‐enhanced tasks (Journal for Research in Mathematics Education, 2010; 41(2):169–202). In this article, we describe our adaptation of Jacobs et al.'s framework for teacher noticing student mathematical thinking to include a focus on making students' technology‐tool engagement explicit when noticing in technology‐mediated environments, the Noticing in Technology‐Mediated Environments (NITE) framework. We describe the theoretical foundations of the framework, provide a video case example, and then illustrate how the framework can be used by mathematics teacher educators to support PSTs' noticing when students are working in technology‐mediated environments.
Sources of hyperintensionality
Authors: Lenta Giorgio 
Published: October 2023

AbstractA wide variety of concepts are nowadays considered to be hyperintensional, and some of them do not seem to involve our representational attitudes. This led some philosophers to identify and defend a notion of worldly hyperintensionality: the idea that some hyperintensional phenomena derive from features of objective reality, independently of how we represent it. Against this view, Darragh Byrne and Naomi Thompson argue that the correct understanding of such phenomena must be conceptualist in nature, and claim that hyperintensionality always derives from features of representations. In the present work I defend the genuine distinction between worldly and representational hyperintensionality through a new framing of the issue: the comparison with worldly intensionality. I argue that locating the sources of hyperintensionality should not be affected by preferences towards any specific semantic framework, and reject Byrne and Thompson's argument against worldly hyperintensionality.
CMV prevention strategies in allogeneic hematopoietic cell transplantation; the role of prophylaxis and pre‐emptive monitoring in the era of letermovir
Authors: Yong Michelle K. , Slavin Monica A. , Chemaly Roy F. , Papanicolaou Genovefa A. 
Published: October 2023

AbstractThe preferred strategy for preventing CMV in at‐risk populations in alloHCT has undergone a significant practice shift in recent years where the pendulum has swung from a pre‐emptive approach to now offering letermovir prophylaxis to all CMV seropositive recipients. Letermovir prophylaxis has resulted in significant reductions in post‐transplant clinically significant CMV infection (csCMVi) as well as other important outcomes such as CMV disease, resistant, and refractory CMV infections and nonrelapse mortality. However, prophylactic strategies are not without some limitations, namely delayed onset CMV infections, delayed CMV‐specific T cell immune reconstitution, increased drug costs and limited data within pediatric populations. Thus, this review aims to provide an overview of prophylaxis and pre‐emptive CMV preventative strategies, and how they are applicable in the current era of letermovir prophylaxis.
Visiones curativas
Authors:   Universidad de la Sabana, Cárdenas Támara Felipe 
Published: October 2023

Las Visiones Curativas honran el misterio de la vida y están abiertas a la meditación, al diálogo con todas las corrientes terapéuticas, con la psicología existencial y trascendente. En toda su sencillez, se abre un canal y dimensión realista para situarnos en un horizonte anti ideológico, cuyas notas son éticas, estéticas y proyectivas. Las Visiones Curativas, en su sencillo juego a partir de la imagen fotográfica, posibilita el juego meditativo, mediado por el uso tecnológico de la cámara, el video y todos los elementos que el arte en la Tierra nos posibilita, en el mencionado diálogo cuaternario y/o trinitario, en sus infinitas posibilidades contemplativas de los elementos de la realidad: Dios, naturaleza, la persona y la sociedad, cuya constitución y ordenes han sido ideologizados, pero cuya realidad es un rasgo distintivo de la realidad y que debe ser objeto de creación desde el trabajo intelectual del universitario, que deberá explorar sentidos y lenguajes de comunicación que desbordan el marco reduccionista y utilitario de las ideología de la muerte que marcan la proyección instrumental de los centros (think thanks) interesados en alimentar la violencia y el no reconocimiento de los planos sinfónicos de la vida en su obsesión por reducir todo al estudio del poder.
Human ApoE2 protects mice against
Plasmodium berghei
ANKA experimental cerebral malaria
Authors: Liang Rui , Rao Hengjun , Pang Qin , Xu Ruixue , Jiao Zhiwei , Lin Lirong , Li Li , Zhong Li , Zhang Yixin , Guo Yazhen , Xiao Nengming , Liu Shengfa , Chen Xiao-Fen , Su Xin-zhuan , Li Jian 
Published: October 2023

ABSTRACT

Cerebral malaria (CM) is a severe neurological complication of
Plasmodium falciparum
infection with acute brain lesions. Genetic variations in both host and parasite have been associated with susceptibility to CM, but the underlying molecular mechanism remains unclear. Here, we demonstrate that variants of human apolipoprotein E (hApoE) impact the outcome of
Plasmodium berghei
ANKA (
Pb
A)-induced experimental cerebral malaria (ECM). Mice carrying the hApoE2 isoform have fewer intracerebral hemorrhages and are more resistant to ECM than mice bearing the hApoE3, hApoE4, or endogenous murine ApoE (mApoE). hApoE2 mice infected with
Pb
A showed increased splenomegaly and IFN-γ levels in serum but reduced cerebral cell apoptosis that correlated with the survival advantage against ECM. In addition, upregulated expression of genes associated with lipid metabolism and downregulated expression of genes linked to immune responses were observed in the brain tissue of hApoE2 mice relative to ECM-susceptible mice after
Pb
A infection. Notably, serum cholesterol and the cholesterol content of brain-infiltrating CD8
+
T cells are significantly higher in infected hApoE2 mice, which might contribute to a significant reduction in the sequestration of brain CD8
+
T cells. Consistent with the finding that fewer brain lesions occurred in infected hApoE2 mice, fewer behavioral deficits were observed in the hApoE2 mice. Finally, a meta-analysis of publicly available data also showed an increased hApoE2 allele in the malaria-endemic African population, suggesting malaria selection. This study shows that hApoE2 protects mice from ECM through suppression of CD8
+
T cell activation and migration to the brain and enhanced cholesterol metabolism.

IMPORTANCE

Cerebral malaria (CM) is the deadliest complication of malaria infection with an estimated 15%–25% mortality. Even with timely and effective treatment with antimalarial drugs such as quinine and artemisinin derivatives, survivors of CM may suffer long-term cognitive and neurological impairment. Here, we show that human apolipoprotein E variant 2 (hApoE2) protects mice from experimental CM (ECM) via suppression of CD8
+
T cell activation and infiltration to the brain, enhanced cholesterol metabolism, and increased IFN-γ production, leading to reduced endothelial cell apoptosis, BBB disruption, and ECM symptoms. Our results suggest that hApoE can be an important factor for risk assessment and treatment of CM in humans.
AI-assisted structural consensus-proteome prediction of human monkeypox viruses isolated within a year after the 2022 multi-country outbreak
Authors: Parigger Lena , Krassnigg Andreas , Grabuschnig Stefan , Gruber Karl , Steinkellner Georg , Gruber Christian C. 
Published: October 2023

ABSTRACT

The monkeypox virus (MPX) belongs to the
Orthopoxvirus
genus of the Poxviridae family, is endemic in parts of Africa and causes a disease in humans similar to smallpox. The most recent outbreak of MPX is already affecting 110 countries, with 86,956 confirmed cases since May 2022 and has consequently become a focus of interest. In particular, a molecular understanding of the virus is essential to study infection processes and pathogen-host interactions, predict tropism changes, or guide drug development and drug discovery as well as vaccine development or vaccine adaptation at a very early stage. Herein, we present a study of the structural proteome of the currently circulating MPX: Our consensus analysis of 3,713 genome sequences sampled within a year after the outbreak revealed 10,580 characteristic candidate open reading frames (ORFs). A search in the non-redundant protein database reduced the number of suspected ORFs to 1,079, of which 210 are representative proteins in typical MPX reference genomes. This should serve as a collection of putative proteins within the currently spreading MPX, a compound of information that could support timely drug discovery, mutational analyses, and vaccine development. We, herein, present the so far most comprehensive structural proteome by providing atomistic 3D models of 210 proteins, generated with three state-of-the-art structure prediction methods, including a mutational analysis of the proteome, with a particular focus on the drug-binding sites of tecovirimat and brincidofovir.

IMPORTANCE
The 2022 outbreak of the monkeypox virus already involves, by April 2023, 110 countries with 86,956 confirmed cases and 119 deaths. Understanding an emerging disease on a molecular level is essential to study infection processes and eventually guide drug discovery at an early stage. To support this, we provide the so far most comprehensive structural proteome of the monkeypox virus, which includes 210 structural models, each computed with three state-of-the-art structure prediction methods. Instead of building on a single-genome sequence, we generated our models from a consensus of 3,713 high-quality genome sequences sampled from patients within 1 year of the outbreak. Therefore, we present an average structural proteome of the currently isolated viruses, including mutational analyses with a special focus on drug-binding sites. Continuing dynamic mutation monitoring within the structural proteome presented here is essential to timely predict possible physiological changes in the evolving virus.
Quarantine experience of healthcare workers in close contact with COVID-19 patients in China: a qualitative study
Authors: Cui Hengmei , Chen Haoyang , Gao Wei , Shi Songsong , Li Yunyun , Li Huiling , Shen Biyu 
Published: October 2023

BackgroundThis study investigated the experiences of front-line healthcare workers who had been in close contact with COVID-19 patients and had been quarantined in order to provide guidance on quarantine measures with more humanistic care when dealing with future public health emergencies.MethodsWe conducted a qualitative study using semistructured, qualitative, in-depth interviews between April and June 2022. The interviews were recorded and transcribed, followed by a thematic analysis. The study followed the Standards for Reporting Qualitative Research.ResultsThis study identified the following four themes: (1) personal psychological changes, (2) increased reflection on life and work during quarantine, (3) the important role of others’ support and (4) different types of demands during quarantine and isolation. Each theme is supported by several subthemes that further illustrate the participants’ experiences.ConclusionsQuarantine of close contacts is necessary to prevent outbreaks. Front-line doctors and nurses are at a greater risk of COVID-19 infection than others. The results showed the psychological reactions of ordinary close contacts, and the unique feelings and experiences of doctors and nurses during the epidemic. Therefore, future research should cooperate with multiple departments to assess their needs, provide them with individualised care and love and give them incentives in order to reduce their psychological burden, improve their quality of life and allow them to engage in healthcare with a healthy mind.
Does the duration of ambulatory consultations affect the quality of healthcare? A systematic review
Authors: León-García Montserrat , Wieringa Thomas H , Espinoza Suárez Nataly R , Hernández-Leal María José , Villanueva Gemma , Singh Ospina Naykky , Hidalgo Jessica , Prokop Larry J , Rocha Calderón Claudio , LeBlanc Annie , Zeballos-Palacios Claudia , Brito Juan Pablo , Montori Victor M 
Published: October 2023

BackgroundThe objective is to examine and synthesise the best available experimental evidence about the effect of ambulatory consultation duration on quality of healthcare.MethodsWe included experimental studies manipulating the length of outpatient clinical encounters between adult patients and clinicians (ie, therapists, pharmacists, nurses, physicians) to determine their effect on quality of care (ie, effectiveness, efficiency, timeliness, safety, equity, patient-centredness and patient satisfaction).Information sourcesUsing controlled vocabulary and keywords, without restriction by language or year of publication, we searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews and Scopus from inception until 15 May 2023.Risk of biasCochrane Risk of Bias instrument.Data synthesisNarrative synthesis.Results11 publications of 10 studies explored the relationship between encounter duration and quality. Most took place in the UK’s general practice over two decades ago. Study findings based on very sparse and outdated evidence—which suggested that longer consultations improved indicators of patient-centred care, education about prevention and clinical referrals; and that consultation duration was inconsistently related to patient satisfaction and clinical outcomes—warrant low confidence due to limited protections against bias and indirect applicability to current practice.ConclusionExperimental evidence for a minimal or optimal duration of an outpatient consultation is sparse and outdated. To develop evidence-based policies and practices about encounter length, randomised trials of different consultation lengths—in person and virtually, and with electronic health records—are needed.Trial registration numberOSF Registration DOI:10.17605/OSF.IO/EUDK8.
Pretreatment radiomic biomarker for immunotherapy responder prediction in stage IB–IV NSCLC (LCDigital-IO Study): a multicenter retrospective study
Authors: Wu Shaowei , Zhan Weijie , Liu Lan , Xie Daipeng , Yao Lintong , Yao Henian , Liao Guoqing , Huang Luyu , Zhou Yubo , You Peimeng , Huang Zekai , Li Qiaxuan , Xu Bin , Wang Siyun , Wang Guangyi , Zhang Dong-Kun , Qiao Guibin , Chan Lawrence Wing-Chi , Lanuti Michael , Zhou Haiyu 
Published: October 2023

BackgroundThe predictive efficacy of current biomarker of immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB–IV non-small cell lung cancer (NSCLC), including its biological context for ICIs treatment response prediction.MethodsCT images from 319 patients with pretreatment NSCLC receiving immunotherapy between January 2015 and November 2021 were retrospectively collected and composed a discovery (n=214), independent validation (n=54), and external test cohort (n=51). A set of 851 features was extracted from tumorous and peritumoral volumes of interest (VOIs). The reference standard is the durable clinical benefit (DCB, sustained disease control for more than 6 months assessed via radiological evaluation). The predictive value of combined radiomic signature (CRS) for pathological response was subsequently assessed in another cohort of 98 patients with resectable NSCLC receiving ICIs preoperatively. The association between radiomic features and tumor immune landscape on the online data set (n=60) was also examined. A model combining clinical predictor and radiomic signatures was constructed to improve performance further.ResultsCRS discriminated DCB and non-DCB patients well in the training and validation cohorts with an area under the curve (AUC) of 0.82, 95% CI: 0.75 to 0.88, and 0.75, 95% CI: 0.64 to 0.87, respectively. In this study, the predictive value of CRS was better than programmed cell death ligand-1 (PD-L1) expression (AUC of PD-L1 subset: 0.59, 95% CI: 0.50 to 0.69) or clinical model (AUC: 0.66, 95% CI: 0.51 to 0.81). After combining the clinical signature with CRS, the predictive performance improved further with an AUC of 0.837, 0.790 and 0.781 in training, validation and D2 cohorts, respectively. When predicting pathological response, CRS divided patients into a major pathological response (MPR) and non-MPR group (AUC: 0.76, 95% CI: 0.67 to 0.81). Moreover, CRS showed a promising stratification ability on overall survival (HR: 0.49, 95% CI: 0.27 to 0.89; p=0.020) and progression-free survival (HR: 0.43, 95% CI: 0.26 to 0.74; p=0.002).ConclusionBy analyzing both tumorous and peritumoral regions of CT images in a radiomic strategy, we developed a non-invasive biomarker for distinguishing responders of ICIs therapy and stratifying their survival outcome efficiently, which may support the clinical decisions on the use of ICIs in advanced as well as patients with resectable NSCLC.
A 50 l Cygno prototype overground characterization
Authors: Amaro Fernando Domingues , Antonietti Rita , Baracchini Elisabetta , Benussi Luigi , Bianco Stefano , Borra Francesco , Capoccia Cesidio , Caponero Michele , Cardoso Danilo Santos , Cavoto Gianluca , Costa Igor Abritta , Dané Emiliano , Dho Giorgio , Di Giambattista Flaminia , Di Marco Emanuele , D’Imperio Giulia , dos Santos Joaquim Marques Ferreira , di Cortona Giovanni Grilli , Iacoangeli Francesco , Kemp Ernesto , Júnior Herman Pessoa Lima , Lopes Guilherme Sebastiao Pinheiro , Júnior Amaro da Silva Lopes , Maccarrone Giovanni , Mano Rui Daniel Passos , Gregorio Robert Renz Marcelo , Marques David José Gaspar , Mazzitelli Giovanni , McLean Alasdair Gregor , Meloni Pietro , Messina Andrea , Monteiro Cristina Maria Bernardes , Nobrega Rafael Antunes , Pains Igor Fonseca , Paoletti Emiliano , Passamonti Luciano , Pelosi Sandro , Petrucci Fabrizio , Piacentini Stefano , Piccolo Davide , Pierluigi Daniele , Pinci Davide , Prajapati Atul , Renga Francesco , Roque Rita Cruz , Rosatelli Filippo , Russo Alessandro , Saviano Giovanna , Spooner Neil John Curwen , Tesauro Roberto , Tomassini Sandro , Torelli Samuele , Tozzi Donatella 
Published: October 2023

AbstractThe nature of dark matter is still unknown and an experimental program to look for dark matter particles in our Galaxy should extend its sensitivity to light particles in the GeV mass range and exploit the directional information of the DM particle motion (Vahsen et al. in CYGNUS: feasibility of a nuclear recoil observatory with directional sensitivity to dark matter and neutrinos,arXiv:2008.12587, 2020). TheCygnoproject is studying a gaseous time projection chamber operated at atmospheric pressure with a Gas Electron Multiplier (Sauli in Nucl Instrum Meth A 386:531,https://doi.org/10.1016/S0168-9002(96)01172-2, 1997) amplification and with an optical readout as a promising technology for light dark matter and directional searches. In this paper we describe the operation of a 50 l prototype named LIME (Long Imaging ModulE) in an overground location at Laboratori Nazionali di Frascati (LNF) of INFN. This prototype employs the technology under study for the 1 cubic meterCygnodemonstrator to be installed at the Laboratori Nazionali del Gran Sasso (LNGS) (Amaro et al. in Instruments 2022, 6(1),https://www.mdpi.com/2410-390X/6/1/6, 2022). We report the characterization of LIME with photon sources in the energy range from few keV to several tens of keV to understand the performance of the energy reconstruction of the emitted electron. We achieved a low energy threshold of few keV and an energy resolution over the whole energy range of 10–20%, while operating the detector for several weeks continuously with very high operational efficiency. The energy spectrum of the reconstructed electrons is then reported and will be the basis to identify radio-contaminants of the LIME materials to be removed for futureCygnodetectors.
Viscous QCD medium effects on the bottom quark transport coefficients
Authors: Shaikh Adiba , Dash Sadhana , Nandi Basanta K. 
Published: October 2023

AbstractThe bottom quark transport coefficients, i.e., drag and diffusion coefficients, have been studied for the collisional and soft gluon radiative processes within the viscous QCD medium. The thermal medium effects are incorporated using the effective fugacity quasiparticle model (EQPM). Both the shear and bulk viscous effects at leading order are embedded through the near-equilibrium distribution functions of the quark–gluon plasma (QGP) constituent quasiparticles. The transport coefficients’ dependence on the bottom quark’s initial momentum and QGP temperature have been investigated. The relative dominance of the radiative over the collisional process for the bottom quark seems to occur at a higher initial momentum compared to that of the charm quark. In contrast, the effect of the viscous corrections seems to be more for the charm quark. Furthermore, we also investigate the validity of the Einstein fluctuation–dissipation theorem for our analysis.