bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visceral obesity augments prescription use: An analysis of the cross-sectional study of NHANES 2011–2018
Authors: Acevedo-Fernández Maximino , Ochoa Precoma Renata , Porchia Leonardo M. , Posadas Victor M. , Torres-Rasgado Enrique , Gonzalez-Mejia M. Elba , López-Bayghen Esther 
Published: February 2025

Background
Visceral obesity (VATob) increases the risk for many diseases. Central obesity has been associated with an augmented prescription use; however, there is a paucity of research focused on VATob. Here, the aim was to evaluate the association between VATob and prescription use.

Methods
Data was collected from the NHANES dataset (2011–2018). Visceral adipose tissue was measured using dual x-ray absorptiometry, and VATob was defined as ≥100 cm2. Prescription use was collected from the RXQ_RX files and classified according to Vademecum. Association between VATob and prescription use was determined with logistic regression and reported as odds ratios (ORs) with 95% confidence intervals (95%CIs).

Results
10,952 participants (weighted: 121,090,702) were included, in which 41.8% were VATob and 52.0% of them had ≥1 prescription. Overall, VATob demonstrated an augmented rate of prescription use when compared to non-VATob (52.0% versus 36.7%, p<0.001), specifically with metabolic (4.5-fold increase), cardiovascular (3.9-fold increase), gastrointestinal (2.5-fold increase), and hematopoietic agents (2.3-fold increase). This was associated with increased the risk for overall prescription use (ORoverall = 1.9, 95%CI: 1.7–2.1, p<0.001). Similar results were observed with metabolic and cardiovascular agents. However, when stratified by BMI, normal weight participants (ORmetabolic = 10.4; 95%CI: 6.5–16.6 & ORcardiovascular = 7.0; 95%CI: 4.4–11.1, p<0.001) had a greater risk than the overweight (ORmetabolic = 4.1; 95%CI: 3.0–5.6 & ORcardiovascular = 3.4; 95%CI: 2.5–4.7, p<0.001) or obese participants (ORmetabolic = 3.5; 95%CI: 2.3–5.3 & ORcardiovascular = 3.5; 95%CI: 2.5–4.9, p<0.001).

Conclusion
VATob is associated with augmented prescription use, particularly with cardiovascular and metabolic agents. This association was higher for normal weight participants.
Tone or tissue? A comparison of trends and risk factors of severe postpartum hemorrhage according to uterine atony or retained tissue in a hospital setting
Authors: Pettersen Silje , Falk Ragnhild Sørum , Vangen Siri , Nyfløt Lill Trine 
Published: February 2025

Objective
To compare trends, outcomes and risk factors for severe postpartum hemorrhage (PPH) due to uterine atony and retained tissue separately.

Study design
This retrospective hospital-based study of severe PPH included deliveries from a 10-year cohort (2008–2017) and a four-year case-control group (2008–2011). Severe PPH was defined as an estimated blood loss of ≥1500 ml or a blood transfusion. Poisson regression was used to estimate the temporal trend in the 10-year cohort. Risk factors were investigated in the case-control group. We performed multinomial regression analysis to investigate associations between pregnancy characteristics and severe PPH caused by uterine atony and by retained tissue compared to controls without severe PPH.

Results
During the 10-year study period, 2.7% of all deliveries were complicated by severe PPH. Uterine atony without concurring retained tissue was the cause in 55.4%, while retained tissue was listed as a cause in 32.2% of the cases. Among women who received ≥ four units of blood products, retained tissue caused 42.6% of cases, and severe PPH resulting in a hysterectomy was caused by retained tissue in 61.2% of cases. The rate of severe PPH caused by uterine atony significantly increased during the study period with an estimated annual percentage change of 8.6%, while the increase in severe PPH due to retained tissue was non-significant. Risk factors associated only with uterine atony were multiple pregnancy, macrosomia, Asian ethnicity and operative delivery, while induction of labor, augmentation of labor, use of anticoagulants and assisted reproduction were associated with both uterine atony and retained tissue.

Conclusion
The observed increased rate of PPH in the study period was mainly driven by an increase in atonic PPH, while the rate of severe PPH caused by retained tissue remained stable. The proportion caused by retained tissue was highest among the most severe cases of PPH. The reason for the increase in severe PPH due to uterine atony, but not retained tissue was not clear, but we speculate that it may be a combination of increasing risk factors with increased awareness of PPH.
Arte, estética, política y crisis
Authors: Ramos Eliana Marisa 
Published: February 2025

El siguiente trabajo pretende recorrer un camino que permita pensar conceptos centrales a la hora de tensionar la relación entre arte, estética y política, y las configuraciones que adquiere este entramado en nuestro país, intentando esbozar algunas observaciones que nos ayuden a caracterizar las expresiones ocurridas en el marco de la crisis de 2001 y las que tuvieron y tienen lugar en la crisis que sobrevino a la pandemia.
Dos aspectos interesantes que podrían ordenar el ejercicio de pensar esta relación tienen que ver, por un lado, con las diferentes miradas sobre la estetización de la política, entendida como un proceso inserto en un tiempo histórico, o por el contrario si debemos pensarla como una cuestión ontológica. Por otra parte, el lugar central ocupado por el espacio público y el cuerpo a partir de las nuevas formas de intervención política denominadas artivismo.
En un recorrido muy fugaz analizo la relación entre estética, política y arte, a partir de pensar dos variables conceptuales claves en este esquema: el espacio público, y los cuerpos. Por otra parte, una dimensión que se revela fundamental para pensar en las condiciones de posibilidad: el tiempo histórico. De esta forma, las crisis de 2001 y 2020 van configurando diferentes formas de irrumpir en el espacio público, diferentes formas de hacer política y de expresarse colectivamente. Se avecinan tiempos de grandes desafíos para el conjunto social en la medida en que podamos torcer la premisa del “sálvese quien pueda” y podamos encontrar las estrategias para volver a creer que la salida es colectiva y el arte es una experiencia creativa que tiene la potencia para crear escenarios políticos de resistencia claves para la vida comunitaria.
ANALISIS KLASIFIKASI MENGGUNAKAN REGRESI LOGISTIK BINER DAN ALGORITMA NAÏVE BAYES CLASSIFIER PADA PENYAKIT HIPERTENSI
Authors: Sahila Riza , Widiharih Tatik , Utami Iut Tri 
Published: February 2025

Hypertension is a primary cause of cardiovascular disease. Approximately 60% of people with hypertension are in developing countries, including Indonesia. In this analytical study, classification will be carried out to prove the status of hypertensive patients or not hypertensive. The classification method used is Binary Logistic Regression and Naïve Bayes Classifier. Binary Logistic Regression is Logistic Regression with the response variable being binary. Naïve Bayes Classifier namely predicting future opportunities using previous data. The factors used in this study were gender, age, height, and weight. The greatest accuracy of classification results is in the proportion of 90%:10%. The accuracy of the classification produced by Binary Logistic Regression method resulted in a sensitivity of 93.33%. The classification accuracy obtained by the Naïve Bayes Classifier with a sensitivity of 63.64%. This shows that the Binary Logistic Regression method has a better sensitivity value.Keywords: Hypertension, Classification, Binary Logistic Regression, Naïve Bayes Classifier, Sensitivity.
ANALISIS MODEL REGRESI COX PROPORTIONAL HAZARD PADA DATA KETAHANAN HIDUP PASIEN HEMODIALISA MENGGUNAKAN METODE BRESLOW
Authors: Saragih Risky Trywita , Wuryandari Triastuti , Fakhriyana Deby 
Published: February 2025

Chronic Kidney Disease is a pathophysiological stage with various etiologies which causes a progressive and irreversible decline in kidney function that culminates in kidney failure, thus requiring routine kidney therapy. Hemodialysis (HD) is one of the therapies for people with kidney disorders who have poor kidney function. The Cox Proportional Hazard Regression Model is a commonly used model in survival analysis to analyze time to events or between events. In the survival analysis data, there may be ties or joint events, so in this study Cox Proportional Hazard regression was used with the Breslow approach. This study aims to determine the factors that affect the survival time of hemodialysis patients, especially patients at Vita Insani Pematang Siantar Hospital, North Sumatra Province. Based on the results of the analysis obtained that hemodialysis patients who have high systolic blood pressure ≥ 140 chances of failure to survive greater than hemodialysis patients with normal systolic blood pressure. Therefore, hemodialysis patients with high systolic blood pressure need special attention.
Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action
Authors: Aurangzeb Sana , Aurongzeb Muhammad , Shamim Shahbaz , Rashid Yasmeen , Khan Khalid Mohammed , Aziz Tariq , Alharbi Metab , Alasmari Abdullah F. 
Published: February 2025

Abstract
The HslVU enzyme complex, a proteasomal analog found in bacteria, consists of two components, i.e., the HslV protease and the HslU ATPase. These proteins come together to form a functional enzyme complex, where the C-terminal helix of each HslU subunit is inserted into the binding pocket of each HslV dimer. This interaction leads to the activation of the HslV protease through allosteric mechanisms, enabling its enzymatic function. This bacterial complex is reflected as an attractive target for drug development due to its presence in disease-causing microorganisms and concurrent absence in humans. The objective of this research was to identify certain promising drug candidates that could excessively stimulate the HslV protease, leading to uncontrolled protein breakdown in the pathogens. Four dihydropyrimidone derivatives have been identified as potential activators of HslV protease exhibiting high docking scores, favorable binding patterns, and significant in vitro activation capabilities. These compounds have demonstrated effective dose 50 values within the sub-micromolar range, i.e., 0.4–0.58 µM. Normal mode analysis investigations provided additional confirmation regarding the stability of the conformational interactions between the HslV protease and the active compounds. In addition, the predicted absorption, distribution, metabolism, excretion, and toxicity properties of these lead compounds remarkably demonstrated their considerable drug-like and non-toxic qualities. This study not only presents more potent small non-peptide activators of the HslV protease but also enhances the understanding regarding the mechanism of HslVU complex activation via small non-peptidic molecules.
“I see wonderful things!” Socio-cognitive experience of Cypriot graffiti in ancient Egypt
Authors: Pestarino Beatrice 
Published: February 2025

Abstract
This article analyses Cypriot graffiti in Egypt engraved by tourists and mercenaries in the Archaic and Classical periods (sixth through fourth centuries BC). These graffiti were inscribed on walls of majestic monuments, e.g., the pyramids in Giza and the temples of Karnak and Abydos. They were written in different languages and scripts all employed on the island, such as Cypriot-syllabic Greek, Eteocypriot – an indigenous language still undeciphered – alphabetic Greek and Phoenician, spread throughout the city-kingdoms into which Cyprus was subdivided. The examination is conducted through a socio-cognitive approach, moving beyond previous scholarship which exclusively focused on the graffiti’s concise texts – often limited to the names and provenance of the writers. By comparing Cypriot Egyptian graffiti with contemporary graffiti and twenty-first-century graffiti written in Cypriot-syllabic script, the analysis will shed light on the role of socio-political environment and landscapes in triggering individuals’ – in this case Cypriots’ – cognitive-behavioral responses which lead them to write these texts. This pioneering approach will allow a better understanding of the underlying reasons why these graffiti were engraved and in which locations. The investigation will provide a better knowledge of the origins of the Cypriot writers, level of literacy, and of their role in society (e.g., insiders vs. outsiders), shedding light on communities that would otherwise be unknown. Furthermore, this study lays the foundations for developing an innovative methodology applicable to epigraphic studies, based on integrating landscape interactions and visual impacts to more traditional examination strategies.
Pragmatic characteristics of diminutive adjectives in Kazakh and English languages
Authors: Manasbayeva Nagima , Sabitova Leilya 
Published: February 2025

Abstract
The study aimed to investigate the functional-pragmatic and communicative-pragmatic use of morphological and syntactic diminutive resources of Kazakh and English in the example of artistic contexts. The following methods were used: comparative-comparative, morphological-syntactic, communicative-pragmatic, analytical-synthetic, and contextual. This paper analysed the main morphological and syntactic resources used for word formation of diminutive adjectives in Kazakh and English languages. In particular, the results of the study showed that synthetic means (use of suffixal morphemes with diminutive semantics) and analytical means (use of special lexemes with diminutive semantics) are frequent in Kazakh. It was determined that suffixal morphemes to express the diminutiveness of adjectives were most often used to warn addressees about the properties of objects and phenomena, to soften categorical evaluation in Kazakh, to diminish the attributes of the object, to demonstrate the incompleteness of the attribute in English. This work can be used in the spheres of communicative linguistics, linguistic pragmatics, word formation, and morphology.
Advances in research on the impact of exosomal miRNAs on liver metastasis of colorectal cancer
Authors: Zhong Xuemei , Guo Dan 
Published: February 2025

Abstract
Colorectal cancer (CRC) is a prevalent malignancy, and its liver metastasis is a key factor leading to patient death. Research has shown that exosomal microRNA (miRNA) plays an important role as a mediator of communication between tumor cells and other cells in the growth, invasion, and metastasis of cancer cells. It also plays a critical role in the occurrence and development of CRC liver metastasis (CRC-LM). This article reviews the biological functions of exosomal miRNA and explores its significant involvement in the mechanism of CRC-LM. It also focuses on the latest progress of extracellular vesicle miRNA in the study of CRC-LM, providing new ideas and methods for future treatments.
Effect of AO 4426 on damping properties of PVA/CPE-AO 2246
Authors: Sheng Jiang , Yong Zhang 
Published: February 2025

Abstract
To investigate the influence of AO 2246 and AO 4426 on the damping properties of polyvinyl alcohol/chlorinated polyethylene (PVA/CPE) composites, a series of composites were prepared by adding AO 4426 into PVA/CPE-AO 2246 under the constant mass ratio of hindered phenol in the composites. The dynamic mechanical properties and microstructure of materials were investigated by DMA, DSC, SEM, and FT-IR. The results showed that a new damping peak appeared near 50 °C by adding AO 4426, which indicated phase separation between AO 4426 and the matrix occurred. With the increase of AO 4426, the damping peaks in the low-temperature section were improved. The value of low-lying region between the double damping peaks, when the hindered phenol coexisted was higher than that of the composites containing only AO 4426, which indicated that the damping temperature domain of the composites was effectively broadened. At the melting temperature of AO 4426 microcrystalline and AO 2246 microcrystalline, no obvious peaks were observed simultaneously, indicating that the hindered phenols inhibited the crystallization of each other.
Role of metal-organic frameworks (MOFs) in electrochemical energy storage devices including batteries and supercapacitors
Authors: Rashid Khashia , Omeema Umme , Raza Abuzar Hasnain , Manzoor Ansa , Abbas Muhammad Sajid , Mustafa Ghulam , Iqbal Muhammad Adnan , Iram Ghazala , Akram Manahil , Ateeq-Ur-Rehman  
Published: February 2025

Abstract
Better energy storage systems are becoming more and more in demand as electric cars, portable electronics, and renewable energy sources become more prevalent. Supercapacitors and batteries, such as lithium-ion batteries (LIBs), sodium-ion batteries (NIBs), lithium sulfur/air batteries, and lithium selenium batteries, are major components of these technologies; yet, stability, cycle life, and energy density are some of the challenges they face. MOFs have emerged as a new material that can solve the problems with unique structural properties. Large surface area and porosity are properties of MOFs which improve the energy density, life cycle and stability of energy storage devices when MOF are used as alectrode material in these devices.This paper analyzes and focuses on the application of MOFs in supercapacitors, LIBs, and SIBs, in which it emphasizes improvement in terms of stability and performance. This review article ends with an overview of the important challenges and the prospects for future research to fully meet the promise of Metal organic frameworks in energy storage applications.
ДИСПЕРСИЯ ТЕМПЕРАТУРЫ ВОЗДУХА В УСЛОВИЯХ ТЕМПЕРАТУРНОЙ ИНВЕРСИИ
Authors: ГЛАДКИХ В.А. , КАМАРДИН А.П. , НЕВЗОРОВА И.В. , ОДИНЦОВ С.Л. 
Published: February 2025

Рассмотрено влияние вертикальных и горизонтальных турбулентных потоков тепла на величину дисперсии температуры воздуха в условиях температурных инверсий различной интенсивности. Показано, что неучет горизонтальных турбулентных потоков тепла в этих условиях может быть причиной существенной недооценки высоты слоя перемешивания существующими моделями.
The effect of vertical and horizontal turbulent heat fluxes on the air temperature variance under conditions of temperature inversions of different intensity is considered. It is shown that the neglect of horizontal turbulent heat fluxes under these conditions in the existing models can lead to significant underestimation of the mixing layer height.
Sleep Study Patterns in Children With Down Syndrome at Different Ages
Authors: Thamkittikun Chalisa , Tovichien Prakarn , Udomittipong Kanokporn , Chotinaiwattarakul Wattanachai , Tiamduangtawan Pinyapach , Sathienkijkanchai Achara , Tanphaichitr Archwin 
Published: February 2025

OBJECTIVES
Down syndrome (DS) is a common genetic syndrome associated with a higher risk for sleep-disordered breathing. We aimed to reveal the age-related developmental difference in sleep architecture and polysomnographic phenotypes and identify the predictors of severe obstructive sleep apnea (OSA) in children with DS.

METHODS
This cross-sectional study included children aged 3-18 with DS who underwent diagnostic polysomnography from 2013-2023. We collected demographic data, sleep symptoms, and polysomnographic results. We analyzed the prevalence of sleep-disordered breathing categorized by age group and used multivariable logistic regression to identify predictors of severe OSA.

RESULTS
Among 95 children, 56.8% had severe OSA and 24.2% had sleep-related hypoventilation. Of those with OSA, 50.5% had positional OSA, and 55.8% had rapid eye movement (REM)-related OSA. Categorized by age groups, children aged 12 -18 years had the highest rates of sleep-disordered breathing compared to other age groups: 75.0% for severe OSA and 82.6% for positional OSA. Age (adjusted OR (95% CI) = 1.24 (1.08-1.43), p = 0.002) and tonsillar hypertrophy (adjusted OR (95% CI) = 3.28 (1.22-8.86), p = 0.019) were significantly associated with severe OSA.

CONCLUSIONS
Sleep-disordered breathing was most frequently diagnosed in children with DS aged 12-18 years compared to other age groups, with a positive correlation between age and OSA severity. Our data support proper surveillance polysomnography for those with tonsillar hypertrophy and during adolescence, even for children with DS who had an initial negative PSG by four years of age.
Identification and Characterization of Novel Bioactive Peptide From Red Seaweed (Pyropia vietnamensis) Proteins
Authors: Basri Nur Iliana , Amin Amiza Mat , Ahmad Fisal 
Published: February 2025

Pyropia vietnamensis is one of the most abundant seaweeds in the Indo-Pacific region. This study aimed to perform an in silico evaluation of P. vietnamensis proteins as potential precursors of bioactive peptides and to determine the novel peptide in terms of its half maximal inhibitory concentration (IC50) and the stability under controlled laboratory environment (in vitro) towards the dominant biological activity. The proteomic profiles of P. vietnamensis proteins were determined using LC-MS/MS analysis. Next, five proteins were chosen and employed for in silico analysis using the BIOPEP-UWM database. The in vitro characterizations of novel peptide were carried out using a dipeptidyl peptidase-IV (DPP-IV) inhibitor screening assay kit. In silico analysis revealed that DPP-IV and angiotensin-converting enzyme (ACE) inhibitors were the most potential bioactive peptides in P. vietnamensis proteins. Calpain 2, papain, pepsin (pH>2), and stem bromelain were predicted as the enzymes with the most potential to produce DPP-IV and ACE inhibitors. The novel peptides predicted were CFA, ACF, RFPS, DEWG, NYCL, CVPR, and DACF. The synthesized CVPR with an IC50 of 0.66 mg/ml exhibited stability at pH 3-7, 30-50 °C, and resisted gastrointestinal digestion. This study revealed P. vietnamensis proteins could offer health benefits due to the therapeutic potential with sustainable industrial applications on functional foods, nutraceuticals, and pharmaceuticals.
Genotype-Based Molecular Mechanisms in Alport Syndrome
Authors: Caparali Emine Bilge , De Gregorio Vanessa , Barua Moumita 
Published: February 2025

Abstract
Alport syndrome (AS) is an inherited disorder characterized by kidney disease, sensorineural hearing loss and ocular abnormalities. AS is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5, which encode the α3, α4 and α5 chains of type IV collagen that forms a heterotrimer expressed in the glomerular basement membrane. Knowledge of its genetic basis has informed the development of different models in dogs, mice and rat that reflect its autosomal and X-linked inheritance patterns as well as different mutation types, including protein truncating and missense variants. A key difference between these two types is the synthesis of α3α4α5(IV), which is not made in autosomal AS (2 pathogenic variants in trans or biallelic) or males with X-linked Alport syndrome due to protein truncating variants. By contrast, α3α4α5(IV) is synthesized in AS due to missense variants. For missense variants, in vitro studies suggest that these cause impaired type IV collagen trafficking and ER stress. For protein truncating variants, knockout models suggest that persistence of an immature α1α1α2(IV) network is associated with biomechanical strain, which activates endothelin-A receptors leading to mesangial filopodia formation. Moreoever, studies suggest that activation of collagen receptors integrins and DDR1 play a role in disease propagation. In this review, we provide an overview of how these genotype-phenotype-mechanisms are key for a precision medicine-based approach in the future.