bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of modularity during development to simplify walking control across multiple steps
Authors: Hinnekens Elodie , Berret Bastien , Morard Estelle , Do Manh-Cuong , Barbu-Roth Marianne , Teulier Caroline 
Published: January 2024

IntroductionWalking in adults relies on a small number of modules, reducing the number of degrees of freedom that needs to be regulated by the central nervous system (CNS). While walking in toddlers seems to also involve a small number of modules when considering averaged or single-step data, toddlers produce a high amount of variability across strides, and the extent to which this variability interacts with modularity remains unclear.MethodsElectromyographic activity from 10 bilateral lower limb muscles was recorded in both adults (n = 12) and toddlers (n = 12) over 8 gait cycles. Toddlers were recorded while walking independently and while being supported by an adult. This condition was implemented to assess if motor variability persisted with reduced balance constraints, suggesting a potential central origin rather than reliance on peripheral regulations. We used non-negative matrix factorization to model the underlying modular command with the Space-by-Time Decomposition method, with or without averaging data, and compared the modular organization of toddlers and adults during multiple walking strides.ResultsToddlers were more variable in both conditions (i.e. independent walking and supported by an adult) and required significantly more modules to account for their greater stride-by-stride variability. Activations of these modules varied more across strides and were less parsimonious compared to adults, even with diminished balance constraints.DiscussionThe findings suggest that modular control of locomotion evolves between toddlerhood and adulthood as the organism develops and practices. Adults seem to be able to generate several strides of walking with less modules than toddlers. The persistence of variability in toddlers when balance constraints were lowered suggests a link with the ability to explore rather than with corrective mechanisms. In conclusion, the capacity of new walkers to flexibly activate their motor command suggests a broader range of possible actions, though distinguishing between modular and non-modular inputs remains challenging.
Novel in vitro evidence on the beneficial effect of quercetin treatment in vascular calcification
Authors: Ceccherini E. , Gisone I. , Persiani E. , Ippolito C. , Falleni A. , Cecchettini A. , Vozzi F. 
Published: January 2024

Vascular calcification is a pathological chronic condition characterized by calcium crystal deposition in the vessel wall and is a recurring event in atherosclerosis, chronic kidney disease, and diabetes. The lack of effective therapeutic treatments opened the research to natural products, which have shown promising potential in inhibiting the pathological process in different experimental models. This study investigated the anti-calcifying effects of Quercetin and Berberine extracts on vascular smooth muscle cells (VSMCs) treated with an inorganic phosphate solution for 7 days. Quercetin has shown the highest anti-calcifying activity, as revealed by the intracellular quantitative assay and morphological analysis. Confocal microscopy revealed downregulation of RUNX2, a key marker for calcified phenotype, which was otherwise upregulated in calcified VSMCs. To investigate the anti-inflammatory activity of Quercetin, culture media were subjected to immunometric assays to quantify the levels of IL-6 and TNF-α, and the caspase-1 activity. As expected, calcified VSMCs released a large quantity of inflammatory mediators, significantly decreasing in the presence of Quercetin. In summary, our findings suggest that Quercetin counteracted calcification by attenuating the VSMC pathological phenotypic switch and reducing the inflammatory response. In our opinion, these preliminary in vitro findings could be the starting point for further investigations into the beneficial effects of Quercetin dietary supplementation against vascular calcification.
On the brain struggles to recognize basic facial emotions with face masks: an fMRI study
Authors: Abutalebi Jubin , Gallo Federico , Fedeli Davide , Houdayer Elise , Zangrillo Federica , Emedoli Daniele , Spina Alfio , Bellini Camilla , Del Maschio Nicola , Iannaccone Sandro , Alemanno Federica 
Published: January 2024

IntroductionThe COVID-19 pandemic impacted public health and our lifestyles, leading to new social adaptations such as quarantine, social distancing, and facial masks. Face masks, covering extended facial zones, hamper our ability to extract relevant socio-emotional information from others’ faces. In this fMRI study, we investigated how face masks interfere with facial emotion recognition, focusing on brain responses and connectivity patterns as a function of the presence of a face mask.MethodsA total of 25 healthy participants (13F; mean age: 32.64 ± 7.24y; mean education: 18.28 ± 1.31y) were included. Participants underwent task-related fMRI during the presentation of images of faces expressing basic emotions (joy or fear versus neutral expression). Half of the faces were covered by a face mask. Subjects had to recognize the facial emotion (masked or unmasked). FMRI whole-brain and regions-of-interest analyses were performed, as well as psychophysiological interaction analysis (PPI).ResultsSubjects recognized better and faster emotions on unmasked faces. FMRI analyses showed that masked faces induced a stronger activation of a right occipito-temporal cluster, including the fusiform gyrus and the occipital face area bilaterally. The same activation pattern was found for the neutral masked &gt; neutral unmasked contrast. PPI analyses of the masked &gt; unmasked contrast showed, in the right occipital face area, a stronger correlation with the left superior frontal gyrus, left precentral gyrus, left superior parietal lobe, and the right supramarginal gyrus.DiscussionOur study showed how our brain differentially struggles to recognize face-masked basic emotions, implementing more neural resources to correctly categorize those incomplete facial expressions.
Productive art engagement in a hybrid format: effects on emotions of older adults during COVID-19 pandemic
Authors: Payne Magali , Galery Kevin , Plonka Alexandra , Lemaire Justine , Derreumaux Alexandre , Fabre Roxane , Mouton Aurélie , Sacco Guillaume , Guerin Olivier , Manera Valeria , Robert Philippe , Beauchet Olivier , Gros Auriane 
Published: January 2024

IntroductionPrevious studies have shown benefits of productive art-activity on frail older adults' mental and physical health. In this study, we investigated the effects of art-producing activities in a hybrid format (in-person and online) in a context of lockdown compared with previous studies taking place in museums and their effects on wellbeing, quality of life, physical frailty, and apathy in older adults.MethodsWe conducted a randomized unicentric control trial on a sample of 126 seniors older than 65 years (mean age 71.9 ± 2.3, 81% women) living in Nice (France). Participants were randomized in two parallel groups (intervention group with n = 62 vs. control group with n = 64) conducted during pandemic, between March and May 2021. The intervention group involved participatory art-based activities conducted in a hybrid format, either in-person or online, once a week for 2 h over a 12-week period. No specific intervention was proposed to the control group. The main aim was to evaluate how this hybrid format would impact the wellbeing, quality of life, and physical frailty of participants. The secondary aim was to compare our results with the previous studies conducted by Beauchet et al., and the third aim was to evaluate the impact of the intervention on apathy. Validated scales were implemented in RedCap and administered at baseline (M0) and at the end of the third month (M3).ResultsThe intervention group showed significant improvement in their quality of life (p = 0.017) and their level of apathy (p = 0.016) after intervention. Emotional blunting increased significantly in the control group (p = 0.016) while it remained stable in the intervention group. No significant improvement was observed on the frailty, and wellbeing scores remained constant in both groups.ConclusionThis randomized control trial confirmed emotional effects on seniors practicing an art-based activity in a hybrid format during pandemic on a weekly basis for 3 months.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT04570813.
The acute effects of pre- and mid-exercise carbohydrate ingestion on the immunoregulatory stress hormone release in experienced endurance athletes—a systematic review
Authors: Christ Tabea , Ringleb Miriam , Haunhorst Simon , Fennen Lena , Jordan Paul M. , Wagner Heiko , Puta Christian 
Published: January 2024

BackgroundIn times of physical stress, the body orchestrates a multisystemic regulatory response. The hormones epinephrine and norepinephrine play a role in the immediate regulation chain, while cortisol is involved in delayed regulation. The release of those stress hormones in response to exercise has previously been reported to elicit diverse immune reactions.ObjectiveThe aim of this systematic review was to examine and present the acute effects of immediate pre- and mid-exercise carbohydrate ingestion on cortisol, epinephrine and norepinephrine levels in experienced endurance athletes.MethodsA systematic literature search was conducted using PubMed, Cochrane Library and Web of Science in accordance with PRISMA guidelines up to February 2023. Randomized controlled trials in English or German language were included if baseline and at least two follow-up measures of blood plasma or serum of chosen stress hormones (cortisol, epinephrine, norepinephrine) were collected in response to prolonged continuous endurance activity. Eligibility furthermore required an acute carbohydrate ingestion of at least 30 g of carbohydrates per hour no more than 30 min before start of the exercise, as well as a placebo-controlled study design.ResultsEleven studies of moderate to high quality were included in this review. Carbohydrate ingestion of at least 30 g per hour was able to attenuate rises in cortisol concentration in majority of the included studies. Epinephrine levels were considerably lower with ingestion of carbohydrates compared to placebo in all studies. Norepinephrine concentrations were largely unaffected by acute carbohydrate feeding.ConclusionPre- and mid-exercise ingestion of carbohydrates seems an effective dietary strategy to attenuate rises in cortisol and epinephrine levels and, thus, an effective countermeasure for endurance exercise-induced increases in stress hormone levels.
MODEL PURCHASE DECISION MELALUI ISLAMIC BRANDING DAN KELOMPOK REFERENSI
Authors: Herawati Heny , Chusnah Chusnah 
Published: January 2024

Tujuan dalam penelitian untuk mengetahui Model Purcase Desition melalui Islamic Branding dan kelompok refrensi di Universitas Islam As-Syafi’iyah. Sampel yang digunakan sebanyak 94 responden dengan menggunakan tehnik Simple Random Sampling. Metode penelitian menggunakan uji validitas dan reliabilitasnya. Uji asumsi klasik meliputi: uji normalitas, uji multikolinearitas, dan uji heterokedastisitas. Metode analisis yang digunakan: analisis regresi linear berganda, analisis korelasi berganda, uji koefisien determinasi (R2), uji t dan uji f. Berdasarkan hasil penelitian secara parsial menunjukkan bahwa Islamic Branding memiliki pengaruh positif dan signifikan terhadap keputusan mahasiswa dengan nilai thitung sebesar 8,431 dengan tingkat signifikan 0,000 < 0,05 kelompok referensi secara parsial menunjukkan bahwa kelompok referensi berpengaruh positif dan signifikan terhadap keputusan pembelian dengan dan thitung sebesar 9,571 dan tingkat signifikan 0,000 < 0,05.
Analisis Perencanaan Strategi Pemasaran Klinik Utama Perisai Husada Menggunakan Metode SWOT dan Quantitative Strategic Planning Matrix
Authors: Lusia Vivi , Fipiana Wahyu Inggar , Rohmatika Tika , Arifin Djauhar 
Published: January 2024

Klinik Utama Perisai Husada adalah suatu klinik dengan konsep dimana pelayanan kesehatan penyakit dalam, saraf dan penunjang lainnya diberikan kepada pasien secara terpadu dalam satu atap. Tujuan penelitian ini adalah untuk mengetahui alternatif strategi pemasaran yang dapat dipakai oleh perusahaan. Pengumpulan data dilakukan melalui tahapan IFAS dan EFAS, analisa data menggunakan IE Matrix dan Matriks SWOT, dan pengambilan keputusan dengan pendekatan QSPM. Hasil penelitian yang ditujukan oleh IE (Internal-External) Matrix menunjukan bahwa Klinik Utama Perisai Husada berasa pada sel V yaitu pertumbuhan dan stabilitas. Berdasarkan hasil tersebut dibuatlah alternatif-alternatif (SO, ST, WO, dan WT) pada matriks SWOT. Keempat strategi tersebut dihitung skor daya tarik melalui metode QSPM yang mana strategi SO (Strength-Opportunity): intensifikasi pemasaran hubungan dengan pelanggan, diferensiasi produk, dan memanfaatkan lokasi yang strategis untuk menarik pangsa pasar potensial, mendapatkan total skor daya tarik terbesar dan dipilih sebagai alternatif strategi pemasaran Klinik Utama Perisai Husada
Analisis Kualitas Produk Songkok Menggunakan Pendekatan Ishikawa Diagram dan Failure Mode and Effect Analysis
Authors: Suparno Suparno , Ni'mah Faziyatun 
Published: January 2024

UD. Arief Bersaudara merupakan home industry yang memproduksi berbagai jenis songkok di Kota Gresik. Agar dapat bersaing dengan usaha sejenis, Perusahaan perlu menjaga dan meningkatkan kualitas produknya. Dalam menjalankan aktivitas produksi, Perusahaan menemukan bahwa produk yang dibuat selama produksi mengalami cacat. Cacat tersebut disebabkan oleh beberapa faktor, baik dari faktor manusia, faktor mesin yang digunakan, faktor bahan baku yang digunakan berkualitas kurang baik, faktor lingkungan yang berpengaruh terhadap pencahayaan, dan juga karena faktor metode yang digunakan. Cacat produk yang terjadi berupa pengesuman kurang bagus, penjahitan kurang rapi, dan pemotongan kurang presisi. Tujuan dari penelitian ini adalah mengidentifikasi penyebab cacat defect serta dengan menghitung nomor prioritas risiko. Metode yang digunakan untuk menemukan dan melakukan identifikasi faktor penyebab cacat pada produksi songkok adalah mengguankan metode Ishikawa Diagram. Sedangkan usulan perbaikan yang menjadi acuan dalam penelitian ini dilakukan dengan cara melakukan perhitungan Risk Priority Number (RPN) dengan menghitung setiap nilai yang ada pada indicator yang diukur untuk mendapatkan nilai RPN tertinggi yang berarti memberikan dampak risiko paling besar. Metode yang digunakan adalah Failure Mode Effect Analysis (FMEA). Berdasarkan hasil penelitian menunjukkan tiga defect yang teridentifikasi dengan nilai Risk Priority Number tertinggi 245 pada pemotongan kurang presisi, dengan nilai RPN 175 pada Penjahitan tidak rapi, dan nilai RPN 150 Pengesuman Kurang Bagus. Rekomendasi perbaikan berdasarkan hasil analisis adalah owner harus melakukan pengawasan yang baik kepada pekerja bagian, selain itu peningkatan keahlian pekerja mutlak dilakukan untuk menjamin kualitas yang baik.
Obtención de iones cobre (II) desde mineral oxidado en presencia de solución de ácido etilendiaminotetraacético en medio básico
Authors: Carpio Darssy , Sueros Félix , Venturo Luis 
Published: January 2024

An experiment was conducted to obtain copper (II) ions in a basic environment using ethylenediaminetetraacetic acid (EDTA) and oxidized copper minerals from Cerro Azoguini in Puno, Peru. Specific objectives included investigating the solubility of Cu2+ ions in a mineral with high silica, limestone, and iron content, as well as studying the influence of pH, EDTA concentration, and extraction time. 1.5 grams of ground mineral at -100 mesh (150 µm), with 80% pass and 6% solids, were leached with a 0.5 M NaHCO3 solution at different pH levels and EDTA concentrations. The results indicated the extraction of 3.5 g/L of Cu2+ ions at pH 10 with 0.12 M EDTA, without agitation, at room temperature (19°C), over a period of 83 hours. It was observed that the NaHCO3 solution extracted copper from the mineral, and EDTA quickly chelated it, forming ionic complexes such as CuHEDTA ∧ (1−), CuHEDTA ∧ (2−) and Cu0HEDTA ∧ (3−). Other metals present in the gangue were not chelated by EDTA, demonstrating its high selectivity based on solubility constants and precipitation formation at different pH levels. Additionally, high copper extraction rates were obtained at a pH of 13.15, possibly due to decreased protons and increased ions from both the reagent and leached mineral. In conclusion, the physicochemical analyses revealed the feasibility of obtaining Cu2+ ions by solubilizing oxidized minerals, followed by rapid chelation with EDTA to form diverse metal complexes depending on the pH of the medium.
Strain and optical characteristics analyses of three-dimentional self-ordered multilayered SiGe nanodots by photoluminescence and Raman spectroscopy
Authors: Ito Yuta , Yokogawa Ryo , Wen Wei-Chen , Yamamoto Yuji , Minowa Takuya , Ogura Atsushi 
Published: January 2024

Abstract
The strain state, optical properties, and band structure of the self-ordered multilayered silicon-germanium (SiGe) nanodots, which are staggered and dot-on-dot alignment and embedded by Si spacer, were evaluated by Raman spectroscopy and low-temperature photoluminescence (PL). These results suggest that the compressive strain applied to the staggered nanodots is smaller than that of the dot-on-dot nanodots, which contributes to the shrinking of the bandgap of the staggered nanodots. Strong PL intensity was observed from the nanodots compared to the single crystalline bulk SiGe due to the carrier confinement and high crystal quality of the nanodots. The stack-controlled nanodots showed a redshift of the PL peaks compared to the bulk SiGe and the effect of strain induced in SiGe nanodots might not be enough to explain this phenomenon. The cause of the redshift was clarified by considering the hetero band structure of the nanodots and the tensile strained spacer.
Peningkatkan Pembelajaran Saintifik Di TK Pelita Pertiwi Kajar Trangkil Pati
Authors: Khosyi'in Nur 
Published: January 2024

The aim of teaching and learning assistance is to improve the quality of learning at Pelita Pertiwi in Kajar kindergarten as our main goal in assisting the learning process with the method of applying a scientific approach, designed in such a way that students actively construct learning concepts according to what they need, by carrying out teaching and learning activities. Using this method of applying a scientific approach can improve the quality of children's learning, from this learning children can carry out activities of observing, asking questions, gathering information, associating and communicating, this method can stimulate children to be more active and as a way of teaching children to be able to solve problems or problem solving. In implementing this scientific learning model, children are the center of learning (student centered approach), this means that students must be able to organize themselves and be able to participate in activities well through the media and learning resources provided, while the teacher is only a facilitator. Because the core objective of scientific learning is designed to activate the role of students from being accredited to accepting to becoming discoverers and communicating science based on the observations they produce.
Keywords: mentoring, learning, scientific methods.
Interpreting the Concept of Ngalap Berkah as Pesantren Tradition in the Perspective of Santri
Authors: Syihabuddin Muhammad , Manggala Kayan , Wafi Hasan Abdul , Maulana Ahmad Harish 
Published: January 2024

Discussion on the tradition of Pesantren is critical and needs to be studied in more depth. This is because the study never ceases to be debated both from the historical side and its characteristics. This goal aims to understand three things: First, the existence of students viewed from the point of historicity through the study of the sociology of religion in Indonesia. Second, the paradigm of the concept of barakah is rooted in the world of Pesantren. Third, understanding the concept of barakah that internalizes students to take action in tabarruk or ngalap berkah social practices. The method used is through a literature study approach, examining the texts of articles with similar themes based on the theory of symbolic interactionism. Data collection is carried out by selection, classification, and categorization. The results found three things: First, in the study of the sociology of religion, Santri is an essential element in the Indonesian subculture called Pesantren. The existence of Santri is the typical determinant of a Pesantren. Second, the concept of barakah that students understand is very diverse; some call it ziyādatul khoīr, the Grace of God, miracles, benefits, and an amulet. In this case, the variety of meanings is adjusted to each insight and experience of Santri in Pesantren. Third, the concept of ngalap berkah becomes a tradition in Pesantren as a form of social practice of Santri which starts from the understanding of each Santri. The term tabarrukan is divided into two parts, namely in the form of ta’zīm and sam’an wa thā’atan. The conclusion of this paper shows that these three aspects (santri, barakah, and ngalap berkah) are a unity that cannot be validated in forming a pesantren.
ANALISIS TINGKAT KOGNITIF KURIKULUM 2013 PADA MATA PELAJARAN PAI KELAS XI DI SMK NEGERI 1 PALOPO BERDASARKAN REVISI TAKSONOMI BLOOM
Authors: Hasnahwati Hasnahwati , Mannuhung Suparman 
Published: January 2024

Benjamin S. Bloom mengembangkan Konsep Taksonomi Bloom pada tahun 1956, seiring dengan perkembangan teori pendidikan, kemudian dikenal dengan nama Taksonomi Bloom. Menurut Anderson dan Krathwohl, pada Taksonomi Bloom revisi memiliki dua dimensi, dua dimensi itu adalah proses kognitif dan pengetahuan. Kurikulum yang diterapkan saat ini yaitu Kurikulum 2013, menggantikan Kurikulum Tingkat Satuan Pendidikan (KTSP). Dalam penelitian ini penulis menggunakan metode deskriptif kualitatif, dengan menganalisis RPP pada mata pelajaran PAI kelas XI SMK Negeri 1 Palopo. Adapun analisis penyebaran tingkat kognitif dalam RPP KI-3, KI-4, KD-3 dan KD-4, berada pada level C2 (memahami), level C3 (menerapkan) dan C4 (menganalisis). Dengan demikian pada mata pelajaran Pendidikan Agama Islam, sudah berada pada kemampuan higher order thinking skill (HOTS).
PENINGKATAN HASIL BELAJAR MATERI BELAJAR MENDESKRIPSIKAN MENGGUNAKAN PROJECT BASED LEARNING PESERTA DIDIK KELAS VII SMP FRATER PALOPO
Authors: Purba Ramainta 
Published: January 2024

Penelitian ini bertujuan untuk meningkatkan hasil belajar pada materi Belajar Mendeskripsikan menggunakan Project Based Learning peserta didik untuk Kelas VII SMP Frater Palopo. Adapun metode yang digunakan pada penelitian ini adalah metode Penelitian Tindakan (action research) yang terdiri dari dua siklus dan setiap siklus terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Berdasarkan hasil penelitian tindakan yang dilakukan, didapatkan bahwa Project Based Learning dapat meningkatkan hasil belajar untuk materi Belajar Mendeskripsikan siswa Kelas VII SMP Frater Palopo. Untuk itu sangat direkomendasikan untuk guru dapat menerapkan model pembelajaran Project Based Learning untuk meningkatkan Hasil Belajar pada materi yang sama. Selain itu, untuk mendapatkan hasil yang lebih maksimal, maka, guru diharapkan mampu membuat Project Based Learning yang sesuai dengan lingkungan dan kebutuhan sekolah yang lebih menarik dan bervariasi.