bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between Off-Pump and On-Pump Beating Heart Coronary Artery Bypass Grafting
Authors: Matsuhashi Kazuki , Takami Yoshiyuki , Maekawa Atsuo , Yamana Koji , Akita Kiyotoshi , Amano Kentaro , Takagi Yasushi 
Published: January 2024

Abstract
Background Although coronary artery bypass grafting (CABG) is performed via three different techniques, conventional, on-pump beating heart CABG (ONBHCAB), or off-pump CABG (OPCAB), data are limited to compare ONBHCAB with OPCAB.
Methods We retrospectively investigated the postoperative cardiac biomarkers, creatine kinase-MB (CK-MB), and troponin I (cTnI), and early and late outcomes in 806 patients undergoing isolated ONBHCAB or OPCAB between February 2008 and September 2022. To eliminate the bias between different groups, propensity score matching was conducted to validate the findings.
Results After matching, the number of each study group totaled 270 patients. In both complete and matched cohorts, early outcomes, including morbidities and mortalities, were similar. However, cTnI and CK-MB levels were significantly higher after ONBHCAB than after OPCAB with median peak cTnI of 9.85 versus 4.60 ng/mL and median peak CK-MB of 48.45 versus 17.10 ng/mL in the matched cohort, which were quite low, below the threshold for values defining perioperative myocardial infarction. At follow-up of 73 ± 45 months, the overall actuarial survival rates were similar between the ONBHCAB and OPCAB patients (86 vs. 87% at 5 years and 64 vs. 68% at 10 years, respectively, in the matched cohort).
Conclusion ONBHCAB may be a comparable alternative to OPCAB with similar early and late outcomes, despite higher elevation of postoperative cardiac biomarkers. ONBHCAB provides more efficient hemodynamic support, providing a better surgical visual field, than OPCAB while reducing the risk of incomplete revascularization.
Mapping the Current Research on Mindfulness Interventions for Individuals with Cerebral Palsy: A Scoping Review
Authors: Tedeschi Roberto 
Published: January 2024

AbstractCerebral palsy (CP) is a chronic neurological disorder that can cause motor and cognitive disabilities. Mindfulness is a form of meditation that has gained attention as a potential therapeutic intervention for improving the health and well-being of patients with CP. Four databases were searched until January 2023. A scoping review was conducted to explore the role of mindfulness in the management of CP by reviewing the available scientific literature. Studies that examined the effects of mindfulness on motor function, communication, and quality of life in patients with CP were analyzed. The gray literature and reference lists of included articles were not identified. The results were presented in numerical and thematic forms. From an initial pool of 30 registered studies, only 3 met the inclusion criteria. These selected studies reported positive effects of mindfulness interventions on communication abilities and stress management in patients with CP. The available evidence suggests that mindfulness may have beneficial effects on motor function, communication, and quality of life in patients with CP. The findings of this review highlight the potential of mindfulness as a complementary therapy for improving the health and well-being of patients with CP.
Early-Onset Dystonia and Visual Impairment Preceding Epileptic Encephalopathy Associated with PIGA Gene Mutation
Authors: Franquelim Catarina , Romana Andreia , Rachão Augusto , Martins Joana Sousa , Monteiro José Paulo , Carvalho João 
Published: January 2024

AbstractThe association between dystonia and early-onset epileptic encephalopathy (EOEE) may have a genetic basis. Phosphatidylinositol glycan biosynthesis class A protein (PIGA) germline mutations have been described in the last decade and associated with refractory EOEEs. Dysmorphisms and visceral abnormalities have also been reported. Here, we present the case of a now 8-month-old child who was evaluated for dystonia, visual impairment, and developmental delay at 2 months of age, followed by refractory focal seizures when he was 4 months old. The remaining examination was normal, besides an accelerated linear growth. His brain magnetic resonance and an extensive metabolic investigation failed to show any abnormalities. At 7 months of age, the exome sequencing found a hemizygous PIGA pathogenic variant-c.1352T > C (p.(Ile451Thr). Seizures improved after the association of carbamazepine with levetiracetam and the beginning of the ketogenic diet. To our knowledge, this is the first time the phenotype associated with this specific mutation is described. Our patient had the singularity of manifesting with remarkable dystonia, over 2 months before the onset of seizures. We also point to the utility of the gene sequencing approach in the diagnosis of patients with dystonia and EOEEs, since identification of the genetic cause may help in patient's management and families' empowerment.
Ist die exsudative neovaskuläre AMD eine chronische Erkrankung? Analyse von Langzeitverläufen unter einer Anti-VEGF-Therapie
Authors: Gunnemann Marie-Louise , Ziegler Martin , Book Marius , Gunnemann Frederic , Rothaus Kai , Spital Georg , Gutfleisch Matthias , Lange Clemens , Lommatzsch Albrecht Peter , Pauleikhoff Daniel 
Published: January 2024

Zusammenfassung
Hintergrund Die Anti-VEGF-Therapie ist die Standardtherapie bei der exsudativen neovaskulären altersabhängigen Makuladegeneration (nAMD), deren Ursache die Entwicklung einer makulären Neovaskularisation (MNV) mit assoziierter Flüssigkeitsexsudation ist. Die therapeutischen Strategien (T&E oder PRN) gingen von einer narbigen Transformation der MNV aus und Exit-Strategien wurden dementsprechend formuliert. Die vorliegende Studie untersucht als Real-Life-Langzeitanalyse diese Hypothese.
Patienten 150 Augen von 97 Patienten wurden über ein mittleres Follow-up von 5,1 Jahren (1 – 14 Jahre) nach Beginn einer Anti-VEGF-Therapie zwischen 2009 und 2017 kontinuierlich bis 2022 nachbeobachtet. Behandelt wurde nach PRN-Schema analog der IVAN-Studie mit Ranibizumab, Aflibercept oder Bevacizumab. Ausgewertet wurden Länge und Intensität der Therapie.
Ergebnisse Von den 150 Augen benötigten 119 Augen (79,3%) eine fortlaufende Anti-VEGF-Therapie, während bei 18 Augen (12,0%) die Therapie aufgrund einer Stabilisierung der Situation beendet werden konnte. Bei 13 Augen (8,7%) wurde die Therapie aufgrund einer Visusverschlechterung auf ein Sehvermögen < 0,05 abgebrochen. Bei fortlaufender Therapie zeigte sich häufig eine lange Therapiedauer mit Therapieindikation beim letzten dokumentierten Arztbesuch, während eine Stabilisierung oft innerhalb der ersten 2 Behandlungsjahre erreicht wurde. Die Therapieintensität nahm vor allem nach 2013 mit Einführen der OCT-basierten Behandlungskriterien auf 7,7 – 8,0 Injektionen/Jahr zu. Die meisten Augen (74,8%) mit fortlaufender Therapie benötigten 6 – 9 Injektionen/Jahr auch noch in den letzten 3 Behandlungsjahren.
Schlussfolgerung Die Tatsache, dass in der vorliegenden Studie erneut bei der Therapie der exsudativen nAMD bei einem Großteil der Patienten (ca. 80%) eine langfristige und intensive Therapienotwendigkeit beobachtet wurde, unterstützt die Einschätzung, dass die nAMD als eine chronische Erkrankung anzusehen ist. Daher erscheint eine proaktive Behandlungsstrategie mit konsequenter Therapie bei jeglichen Aktivitätszeichen sinnvoll. Insbesondere im Hinblick auf die Gefahr des irreversiblen Visusverlusts ist zudem die Langzeitadhärenz der Patienten für ein bestmögliches langfristiges Therapieergebnis entscheidend.
Applications of Quantum Chemistry in Biomimetic Syntheses of Polycyclic Furanocembrane Derivatives
Authors: Gao Zhanghua , Tang Bencan , Wang Di , Zhou Tao , Ren Jianfeng , Hirst Jonathan D. 
Published: January 2024

AbstractThis account summarizes the guidance provided by quantum chemical calculations towards the biomimetic syntheses of polycyclic marine furanocembrane derivatives. Polycyclic furanocembrane derivatives are a group of structurally complex and biologically important marine natural products isolated from marine corals. Their syntheses are challenging due to their structural complexity. Biomimetic synthetic proposals are made and some are verified via chemical synthesis. Computational chemistry can support these biomimetic syntheses. Hence, we describe herein the synthetic and computational attempts that we have made on the biomimetic syntheses of polycyclic furanocembrane derivatives, including intricarene, bielschowskysin, providencin and plumarellide.1	Introduction2	Computational Methodology3	Introduction to Polycyclic Furanocembrane Derivatives4	Biomimetic Syntheses of Intricarene, Bielschowskysin and Providencin5	Computational Studies on the Biomimetic Synthesis of Intricarene6	Computational Studies on the Biomimetic Synthesis of Bielschowskysin7	Computational Studies on the Biomimetic Synthesis of Providencin8	Computational Studies on the Biomimetic Synthesis of Plumarellide9	Conclusion
Retraction Note: Marriage and Marital Fidelity in Interparental Relationship: A View from Religious Perspective
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionThe above article published in Journal of Child Science in Volume 13, Number 01, e58–e61, on May 4, 2023 (DOI: 10.1055/s-0043-1768652), has been retracted as it is lacking scientific base.
Flap Advancement Technique for Scalp Hair Preservation in Massive Cutis Verticis Gyrata
Authors: Javed Bilal , Rao Amina , Abdullah Waleed , Amber Akasha , Amin Mughese 
Published: January 2024

AbstractCutis verticis gyrata (CVG) is a rare skin condition characterized by ridges and furrows resembling the brain. CVG falls under three categories: primary essential, primary nonessential, and secondary. This case report focuses on primary essential CVG, where approximately a fourth of the scalp and a significant portion of the forehead and eyelid were involved.Flap advancement after skin expansion was performed to rectify the disorder. This technique adequately covers the residual defect postexcision and preserves hair growth in affected regions. It is a successful skin expansion technique to cover the exposed scalp, preserve hair growth, and achieve excellent cosmetic results. Our approach demonstrates a promising solution for severe cosmetic disfigurement in primary essential CVG, positively impacting both the physical appearance and psychosocial well-being of the patient.
Updates in the Management of Paraneoplastic Syndrome
Authors: Verma Neha , Jaffer Muhammad H. , Kolli Avinash S. , Mokhtari Sepideh 
Published: January 2024

AbstractParaneoplastic neurological syndromes (PNS) are defined as remote neurologic immune-mediated effects triggered by underlying systemic tumors. While recognizing specific syndromes can aid early cancer detection, overutilization of paraneoplastic assays in the absence of a classic syndrome can precipitate overdiagnosis and overtreatment. PNS involve autoantibodies targeting intracellular or extracellular antigens, with variable immunotherapy responses based on antigen type. Diagnosing PNS is challenging, requiring exclusion of other differential diagnoses. New diagnostic criteria classify PNS into high-risk and intermediate-risk phenotypes based on clinical phenotype, neuronal antibodies, and cancer presence. Patients with cell surface antibodies respond better to immunotherapies compared to those with intracellular antigen targets. Understanding PNS syndromes, serological markers, and oncological features guides management, which facilitates initiation of immunosuppression for PNS alongside treatment of the underlying neoplasm, thereby improving neurologic and oncologic outcomes. Initial treatments often include intravenous methylprednisolone, plasma exchange, or intravenous immunoglobulins. Second-line immunosuppressants like rituximab or cyclophosphamide may be necessary if initial treatments fail. Specific therapies vary based on antibody target. Here, we summarize the current approach to the investigation, diagnosis, and treatment of patients with suspected PNS.
Neurologic Complications in Adult Cancer Survivorship
Authors: McGranahan Tresa Michelle , Figuracion Karl Cristie , Goldberg Myron , Sheppard David P. 
Published: January 2024

AbstractOver the past decade, the improvement in cancer diagnostics and therapeutics has extended the overall survival of patients diagnosed with cancer including brain cancer. However, despite these unprecedented medical successes, patients continue to experience numerous neurologic complications after treatment that interfere with their independence, functionality, and overall quality of life. These include, among others, cognitive impairment, endocrinopathies, peripheral and cranial neuropathies, and vasculopathy. This article describes the long-term neurologic complications cancer survivors commonly experience to increase awareness of these complications and discuss treatments when available. Further research is necessary to understanding of mechanisms of neurologic injury and advance diagnosis and treatment. Effective patient education, monitoring, and managing neurologic issues after cancer treatment may improve independence, functionality, and quality of life during survivorship.
How did you perceive the lifestyle changes caused by the COVID-19 pandemic?
Authors: Tamaki Tetsuya , Nozawa Wataru , Kitsuki Akinori 
Published: January 2024

AbstractThis study did five surveys between April 2020 and March 2021 to look at how lifestyle changes during the pandemic affected well-being. These surveys covered all of Japan and were done both before and after the state of emergency was lifted. Applying the fixed-effects method to the panel data acquired in this manner, the analysis focused on subjective well-being and behavior during the COVID-19 pandemic. The results showed that teleworking during the pandemic may have increased life satisfaction, especially among young people. Although self-restraint behavior reduced well-being among young people, it tended to increase well-being among elderly individuals. On the other hand, self-restraint behavior by partners was found to lead to a decline in well-being among elderly individuals. In addition, it was observed that both the declaration of a state of emergency and the infection status had minimal impact on life satisfaction and happiness across all generational groups. Thus, the results show that lifestyle changes during the pandemic did not necessarily harm well-being, suggesting that the positive or negative impacts of factors differ from generation to generation.
Is cryptocurrency a hedging tool during economic policy uncertainty? An empirical investigation
Authors: He Chengying , Li Yong , Wang Tianqi , Shah Salman Ali 
Published: January 2024

AbstractIn light of the increasing investor interest in cryptocurrencies (CR) as alternative financial assets in financial markets, we sought to examine the connection between economic policy uncertainty (EPU) and cryptocurrencies. To do so, monthly data for Bitcoin (BTC), Ethereum (ETH), and Tether (THT) from January 2021 to April 2023 were employed. We utilized quantile regression and Granger causality analysis to investigate the relationship between EPU and cryptocurrencies. The initial results of this study suggest that EPU has little effect on the cryptocurrency market in the short-term. To enhance the strength and validity of these findings, we performed separate evaluations tailored to the unique contexts of the United States and China. The results revealed that the effects of EPU were adverse and statistically insignificant for China, while the situation differed slightly for the United States. Given that the United States has the most developed economy, its policies have a significant influence globally. As a result, cryptocurrencies have the potential to serve as efficient hedging tools. Furthermore, we incorporated nonlinear autoregressive distributed lag (NARDL) analysis to assess the asymmetric impact of EPU on cryptocurrencies by adopting both short-term and long-term perspectives. The outcomes demonstrated that both Bitcoin and Ethereum can serve as hedging tools in the short-term, although this utility diminishes in the long-term. Conversely, Tether displayed a positive association with EPU in the long-term. The findings of this study hold significance for policy-makers, offering valuable insights related to structuring efficient policies. The recommendations include fostering a rational framework for active participation from various stakeholders, including investors, governmental bodies, central banks, stock exchanges, and financial institutions. This collaborative effort aims to mitigate irrational fluctuations and enhance the acceptability of cryptocurrencies. In essence, this research underscores the potential of cryptocurrencies as a secure hedge against short-term EPU. However, we caution against assuming that any single cryptocurrency can consistently serve as a dependable investment haven.
The community of lactic acid bacteria during kimoto-style seed mash making process and its control
Authors: Takahashi Masayuki 
Published: January 2024

ABSTRACT
Kimoto-style seed mash making processes such as the kimoto and yamahai-moto processes are driven by various microorganisms, and it is very important to make lactic acid bacteria grow stably for the brewing of a sake product with consistent quality. A model of bacterial transition from spherical lactic acid bacteria to rod-shaped lactic acid bacteria during kimoto-making has been advocated, but the model cannot explain all cases of a transition of a bacterial community during kimoto-making at various breweries. Several studies have described unique bacterial transition patterns that differ from those considered in the proposed model, and it is possible that factors such as differences in the initial bacterial community among breweries may cause the diversity of bacterial transitions. In this minireview, I summarize the research concerning the community of lactic acid bacteria during the kimoto-style seed mash making process, and I discuss how stable lactic acid fermentation can be achieved.
Quantification of polyprenyl diphosphates in Escherichia coli cells using high-performance liquid chromatography
Authors: Jitsukawa Tomotaka , Watanabe Soichiro , Shigeri Yasushi , Fujisaki Shingo 
Published: January 2024

ABSTRACT
Dephosphorylation of undecaprenyl diphosphate is a crucial step in the synthesis of undecaprenyl phosphate, which is essential for cell wall synthesis. We have developed a method for the quantification of intracellular polyprenyl diphosphates, which have never before been measured directly. Polyprenyl phosphates and diphosphates prepared by chemical phosphorylation of polyprenols from Staphylococcus aureus were used to establish the conditions for fractionation by ion-exchange chromatography and high-performance liquid chromatography (HPLC). By using an elution solvent containing tetraethylammonium phosphate as an ion-pair reagent for HPLC, polyprenyl phosphate and polyprenyl diphosphate with carbon numbers from 40 to 55 could be detected as separate peaks from the reversed-phase column. This analytical method was applied to lipids extracted from Escherichia coli to determine the intracellular levels of octaprenyl phosphate, undecaprenyl phosphate, octaprenyl diphosphate, and undecaprenyl diphosphate. This is the first report of separate measurement of cellular levels of polyprenyl phosphates and polyprenyl diphosphates.
Predicting drug synergy using a network propagation inspired machine learning framework
Authors: Jin Qing , Zhang Xianze , Huo Diwei , Xie Hongbo , Zhang Denan , Liu Lei , Zhao Yashuang , Chen Xiujie 
Published: January 2024

Abstract
Combination therapy is a promising strategy for cancers, increasing therapeutic options and reducing drug resistance. Yet, systematic identification of efficacious drug combinations is limited by the combinatorial explosion caused by a large number of possible drug pairs and diseases. At present, machine learning techniques have been widely applied to predict drug combinations, but most studies rely on the response of drug combinations to specific cell lines and are not entirely satisfactory in terms of mechanism interpretability and model scalability. Here, we proposed a novel network propagation-based machine learning framework to predict synergistic drug combinations. Based on the topological information of a comprehensive drug–drug association network, we innovatively introduced an affinity score between drug pairs as one of the features to train machine learning models. We applied network-based strategy to evaluate their therapeutic potential to different cancer types. Finally, we identified 17 specific-, 21 general- and 40 broad-spectrum antitumor drug combinations, in which 69% drug combinations were validated by vitro cellular experiments, 83% drug combinations were validated by literature reports and 100% drug combinations were validated by biological function analyses. By quantifying the network relationships between drug targets and cancer-related driver genes in the human protein–protein interactome, we show the existence of four distinct patterns of drug–drug–disease relationships. We also revealed that 32 biological pathways were correlated with the synergistic mechanism of broad-spectrum antitumor drug combinations. Overall, our model offers a powerful scalable screening framework for cancer treatments.
Computational drug repurposing for viral infectious diseases: a case study on monkeypox
Authors: Saha Sovan , Chatterjee Piyali , Nasipuri Mita , Basu Subhadip , Chakraborti Tapabrata 
Published: January 2024

Abstract
The traditional method of drug reuse or repurposing has significantly contributed to the identification of new antiviral compounds and therapeutic targets, enabling rapid response to developing infectious illnesses. This article presents an overview of how modern computational methods are used in drug repurposing for the treatment of viral infectious diseases. These methods utilize data sets that include reviewed information on the host’s response to pathogens and drugs, as well as various connections such as gene expression patterns and protein–protein interaction networks. We assess the potential benefits and limitations of these methods by examining monkeypox as a specific example, but the knowledge acquired can be applied to other comparable disease scenarios.
Comparisons and optimization of two absorption chiller types by considering heat transfer area, exergy and economy as single-objective functions
Authors: Qiu Yida , Wang Jingkun , Han Jing , Chen Yuzhu , Wang Jun , Lund Peter D 
Published: January 2024

Abstract
Absorption cooling technology is an environmentally friendly method to generate continuous chilled water making use of multiple thermal sources, such as waste heat and renewable thermal energy. In this study, two absorption chillers (nominal capacity of 400 kW) with series and parallel connections are evaluated. To research the ideal configuration of chillers after thermodynamic analysis, the structures of the chillers are optimized using the particle swarm optimization algorithm by considering the heat transfer area (HTA), exergy efficiency and total annual cost as single-objective functions. The impact of temperature differences between external and internal flows, heat exchanger efficiencies and the solution allocation ratio is estimated. The optimized HTA, coefficient of performance, exergy efficiency and total annual cost are 149.0 m2, 1.56, 29.44% and $229 119 for the series-connected chiller, and 146.7 m2, 1.59, 31.45% and $234 562 for the parallel-connected type, respectively. Under the lowest HTA condition, compared with the reference simulation results, the energy and exergy performances are improved, while the annual total cost is higher. The annual total cost is highest when maximizing the exergy efficiency, which is attributed to the increase in the HTA. The operating cost accounts for 27.42% (series type) and 26.54% (parallel type) when the annual cost is the lowest.