bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presas e sedução: monstruosidade e desejo em "La Morte Amoureuse", de Théophile Gautier e "Carmilla", de Sheridan Le Fanu
Authors: Gonçalves Alanis Zambrini 
Published: November 2023

Por meio de duas narrativas sobre vampiros, sendo elas La Morte Amoureuse (1836), de Théophile Gautier e Carmilla (1872), de Sheridan Le Fanu, este artigo pretende estudar o modo como a monstruosidade é articulada em meio a essas narrativas, principalmente levando em conta a ideia da monstruosidade moral, bem como a relação entre o monstro e o desejo, ao considerar a sedução inerente que permeia a figura do vampiro, especialmente no que tange ao sentimento de asco e desejo gerado pelo monstro. Assim, este artigo busca mostrar uma breve história sobre o vampiro na cultura literária, em que a criatura passa do folklore à figura do vampiro aristocrático e sedutor. Do mesmo modo, pretende-se entender a maneira como a monstruosidade é exposta nas duas obras e como ela está relacionada ao sentimento de desejo e de sedução.
Moral Excuse to the Pacifist’s Rescue
Authors: Hereth Blake 
Published: November 2023

Abstract
Pacifism1 is the view that necessarily, the nonconsensual physical harming of pro tanto rights-bearers is all-things-considered morally impermissible. Critics of pacifism frequently point to common moral intuitions about self-defenders and other-defenders as evidence that pacifism is false and that self- and other-defense are often morally justified. I call this the Justification View and defend its rival, the Excuse View. According to the latter, a robust view of moral excuse adequately explains the common moral intuitions invoked against pacifism and is compatible with pacifism. The paper proceeds in five steps. First, I identify ten intuitive data points that require explanation. Second, I introduce the justification/excuse distinction. Third, I demonstrate the Excuse View’s equal explanatory power with respect to the intuitive data. Fourth, I defend the Fair Use Principle: When evaluating the plausibility of rival theories J and E, the use of datum d’s full intuitive force against E and for J is epistemically permissible only if (i) d is better explained by J than E and (ii) no intuitive components of d are equally well-explained by E. Finally, I conclude that the conjunction of pacifism and the Excuse View renders the intuitive defense of the Justification View largely moot, and that this is a substantial victory for pacifism.
Fabrication and characterization of copper and copper alloys reinforced with graphene
Authors: Bident Antoine , Delange Florence , Labrugere Christine , Debiemme-Chouvy Catherine , Lu Yongfeng , Silvain Jean-François 
Published: November 2023

The consistent rise in current density within electrical wires leads to progressively more substantial heat losses attributed to the Joule effect. Consequently, mitigating the electrical resistivity of copper wires becomes imperative. To attain this objective, the development of a composite material that incorporates a more conductive reinforcement, like graphene, holds great promise. The conception of a copper/graphene composite using a powder metallurgy-based approach is presented. An optimum graphene quantity of 0.06 vol.% was obtained by calculation in order to limit the phenomenon of overlapping layers. This synthesis technique enables the dispersion of graphene and the meticulous control of the interface through the growth of CuO(Cu) nanoparticles that are tightly bonded to the reinforcement. The increase in the hardness of the various materials with separation of the graphene sheets by ultrasonic treatment (55.3 to 67.6 HV) was obtained. It is an indicator of the correct distribution of the reinforcement. The influence on the electrical properties of dendritic copper (ρe = 2.30 µΩ.cm) remains limited, resulting in a modest reduction in electrical resistance of around 1.4%. Nevertheless, for flake copper (2.71 µΩ.cm) and brass (7.66 µΩ.cm), we achieved a more substantial reduction of 2.7% and 10%, respectively. With the improvement of graphene quality, there exists a greater potential for further enhancing the electrical properties.
Movements to Combat Sex-Trafficking: The Social Construction of a Global Problem and Its Solutions
Authors: Allin Peggy-Jean M. , Thomas George M. 
Published: November 2023

In this paper we analyze the international movements against sex-trafficking, identifiable for 150 years. We critically assess actor-centric approaches within IR that assume a tight connection between intentional actors and a singular norm. We build on critical research to develop a cultural institutional approach that focuses on the intertwining of actors and institutions and on how outcomes are loosely coupled from actors’ actions. Several empirical implications are delineated that guide and are assessed by our analysis of the anti-sex-trafficking history. Using the lens of cultural institutionalism, the resulting interpretative history identifies patterns that support the implications and utility of the theory and that actor-centric perspectives have slighted: actors and norms are embedded in institutions, change was multidimensional and repeatedly difficult to label as success or failure, outcomes often were long-term through weak connections, anti-sex-trafficking movements were affected by distinct issue areas, change occurred episodically through institutional workspaces from early conferences, and conventions of the League of Nations to Vienna 1993 and Palermo 2000. We discuss the contributions of our analysis and the implications for critical theories of how a social problem and its solutions are constructed leading to international socio-political change. Les mouvements de lutte contre la traite à des fins d’exploitation sexuelle : La construction sociale d’un problème mondial et de ses solutions
Kinetics of C-reactive protein during extracorporeal membrane oxygenation
Authors: Lichter Yael , Gal Oz Amir , Carmi Uri , Adi Nimrod , Nini Asaph , Angel Yoel , Nevo Andrey , Aviram Daniel , Moshkovits Itay , Goder Noam , Stavi Dekel 
Published: November 2023

Background: The exposure of blood to the artificial circuit during extracorporeal membrane oxygenation (ECMO) can induce an inflammatory response. C-reactive protein (CRP) is a commonly used biomarker of systemic inflammation. Methods: In this retrospective observational study, we analyzed results of daily plasma CRP measurements in 110 critically ill patients, treated with ECMO. We compared CRP levels during the first 5 days of ECMO operation, between different groups of patients according to ECMO configurations, Coronavirus disease 2019 (COVID-19) status, and mechanical ventilation parameters. Results: There was a statistically significant decrease in CRP levels during the first 5 days of veno-venous (VV) ECMO (173 ± 111 mg/L, 154 ± 107 mg/L, 127 ± 97 mg/L, 114 ± 100 mg/L and 118 ± 90 mg/L for days 1–5 respectively, p < 0.001). Simultaneously, there was a significant reduction in ventilatory parameters, as represented by the mechanical power (MP) calculation, from 24.02 ± 14.53 J/min to 6.18 ± 4.22 J/min within 3 h of VV ECMO initiation ( p < 0.001). There was non-significant trend of increase in CRP level during the first 5 days of veno arterial (VA) ECMO (123 ± 80 mg/L, 179 ± 91 mg/L, 203 ± 90 mg/L, 179 ± 95 mg/L and 198 ± 93 for days 1–5 respectively, p = 0.126) and no significant change in calculated MP (from 14.28 ± 8.56 J/min to 10.81 ± 8.09 J/min within 3 h if ECMO initiation, p = 0.071). Conclusions: We observed a significant decrease in CRP levels during the first 5 days of VV ECMO support, and suggest that the concomitant reduction in ventilatory MP may have mitigated the degree of alveolar stress and strain that could have contributed to a decrease in the systemic inflammatory process.
Assessment of Self-Regulation at School Entry: A Literature Review of Existing Screening Tools and Suitability for the Aotearoa New Zealand Context
Authors: Barrett-Young Ashleigh , Martin Rachel , Clifford Amanda E. , Schaughency Elizabeth , McLauchlan Jimmy , Healey Dione 
Published: November 2023

This literature review investigates tools used to assess self-regulation at school entry and to inform recommendations for use in Aotearoa New Zealand. We were particularly interested in identifying self-regulation screening tools that had been developed from Indigenous frameworks to enhance likelihood of culturally empowering assessment. APA PsycInfo and Clarivate Web of Science databases were searched for articles on self-regulation screening at school entry. Screening tools were included if they met the following criteria: available in English or te reo Māori (the two predominant written languages of Aotearoa New Zealand); appropriate for children aged 5–6 years; and focus on self-regulation or contain a component assessing self-regulation. 39 screening tools which met the criteria were identified. Overall, most tools were developed from a Euro-American perspective and many were deficit- and/or clinically-focused. Issues with translating screening tools to other cultures are discussed, specifically in the context of Aotearoa New Zealand.
Radiation processing of bacterial cellulose-monolaurin wound dressing: Physicochemical effects, functional analysis, and sterilization
Authors: Tranquilan-Aranilla Charito , Flores Jeric , Gallardo Alvin Kier , Abrera Gina , Pares Franklin 
Published: November 2023

A commercial bacterial cellulose-monolaurin wound dressing was investigated for changes in the chemical structure, mechanical strength, thermal degradation, morphology, and functional swelling properties after exposure to gamma and electron beam radiations at doses 15-50 kGy. Radiation-induced oxidation occurred as seen in the FT-IR peaks at 1720-1750 cm−1. Degradation of the cellulosic network was observed in tensile strength reduction and shift in degradation temperature to lower values. The SEM cross-section images of the irradiated dressings revealed a less dense nanostructure network compared to the non-irradiated samples while the XRD diffractograms indicated a change in lattice direction/plane. Despite these changes, irradiation caused no significant effect on the functional properties especially at 15-25 kGy doses where most biomedical devices are sterilized. All irradiated wound dressings exhibited physical integrity, increased exudate absorption, and water vapor transmission rate - properties beneficial to wound-healing functionality. The pre-selected sterilization dose of 15 kGy for each ionizing radiation was successfully verified and substantiated following ISO 11137-2:2016, hence ionizing radiation is a suitable sterilization modality for the product.
A Prospective Study of an Early Prediction Model of Attention Deficit Hyperactivity Disorder Based on Artificial Intelligence
Authors: Wang Gang , Li Wanyue , Huang Shixiong , Chen Zhuoming 
Published: November 2023

Objective: To explore the relationship between the Parent Symptom Questionnaire (PSQ) and attention deficit hyperactivity disorder (ADHD) in China, and the application value of PSQ questionnaire. Method: Two hundred two children aged 3 to 14 years were enrolled in this study. Statistical methods were used to screen characteristic factors and explore the relationship between PSQ items and ADHD. Machine learning algorithms were used to evaluate the clinical application value of PSQ in screening ADHD. Results: By Mean-Whitney U test, LASSO regression and decision tree, 44, 24 and 12 items were screened out from PSQ with high correlation with ADHD. Then the above items were classified, and the accuracy reached more than 90%. Moreover, the items of ADHD hyperactivity index of PSQ under artificial intelligence algorithm are different from those of PSQ. Conclusion: There are some differences in the items of hyperactivity index between the PSQ and ADHD in China. The artificial intelligence algorithm model of ADHD children based on PSQ scale has a high accuracy.
Food insecurity and glycemic goals among Medicare beneficiaries with type 2 diabetes
Authors: Massey McKayla , Stewart Morgan P , LaManna Jacqueline B , Park Chanhyun , Ng Boon Peng 
Published: November 2023

Objective To examine the association between food insecurity and achieving glycemic goals among Medicare beneficiaries with type 2 diabetes. Methods This study analyzed the nationally representative 2019 Medicare Current Beneficiary Survey of 1340 beneficiaries aged ≥65 years with type 2 diabetes. The binary dependent variable was whether beneficiaries’ blood glucose was at target (A1C ≤ 7.5% or average fasting blood glucose of ≤140 mg/dL, all/most of the time). Food insecurity, a binary variable, was adapted based on the USDA's food security questions. A survey-weighted multivariable logistic model, adjusted for sociodemographics and comorbidities, was conducted to estimate predictive margins for comparing prevalence of having above-target blood glucose levels across groups. Results Of study beneficiaries, 20.9% reported not achieving glycemic targets. The predictive marginal prevalence of having higher than target blood glucose levels was significantly greater in females over males (23.8% [95% confidence interval [CI], 20.1–27.4] vs 17.6% [14.3–20.9]); those with less than high school education over those with college education (31.0% [23.6–38.3] vs 18.6% [14.8–22.3]); and those reporting food insecurity over their counterparts (33.4% [24.5–42.3] vs 19.1% [16.6–21.7]). Conclusions Sociodemographic disparities related to achieving blood glucose goals were observed. Screening for food insecurity and related interventions should be considered for at-risk beneficiaries with diabetes.
Long-term risk-factor control and secondary prevention are insufficient after first TIA: Results from QregPV
Authors: Bager Johan-Emil , Jood Katarina , Nordanstig Annika , Andersson Tobias , Nåtman Jonatan , Hjerpe Per , Rosengren Annika , Mourtzinis Georgios 
Published: November 2023

Introduction: Long-term risk-factor control and secondary prevention are not well characterized in patients with a first transient ischemic attack (TIA). With baseline levels as reference, we compared primary-care data on blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), smoking, and use of antihypertensives, statins and antiplatelet treatment/oral anticoagulation (APT/OAC) during 5 years after a first TIA. Patients and methods: Patients in QregPV, a Swedish primary-care register for the Region of Västra Götaland, with a first TIA discharge diagnosis from wards proficient in stroke care 2010 to 2012 were identified and followed up to 5 years. BP, LDL-C, smoking, use of antihypertensives, statins, APT/OAC, and achievement of target levels were calculated. We used logistic mixed-effect models to analyze the effect of follow-up over time on risk-factor control and secondary prevention treatment. Results: We identified 942 patients without prior cerebrovascular disease who had a first TIA. Compared to baseline, the first year of follow-up was associated with improvements in concomitant attainment of BP <140/90 mmHg, LDL-C < 2.6 mmol/L and non-smoking, which rose from 20% to 33% (OR 2.08, 95% CI 1.38–3.13), but then stagnated in years 2–5. In the first year of follow-up, 47% of patients had complete secondary prevention treatment (antihypertensives, APT/OAC and statin), but continued follow-up was associated with a yearly decrease in secondary prevention treatment (OR 0.94, 95% CI 0.94–0.98). Conclusion: Risk-factor control was inadequate, leaving considerable potential for improved secondary prevention treatment after a first TIA in Swedish patients followed up to 5 years.
Factors associated with living will among older persons receiving long-term care in Finland
Authors: Andreasen Paula , Forma Leena , Pietilä Ilkka 
Published: November 2023

Background: A living will document is known to be an important tool for preparing for future care together with healthcare professionals. A living will supports an older person’s self-determination and autonomy. Only a few studies have approached the underlying factors of a living will document among older long-term care recipients. Objectives: To explore how common having a living will was among older persons receiving home care or round-the-clock long-term care, as well as to evaluate associations between socio-demographical factors and functional capacity with a living will. Design: The study population consisted of older persons receiving long-term care in Finland in 2016–2017. Data were collected via individual assessments at home or at a care facility. The questions in the assessment covered health, functional capacity, service use, and social support. Methods: Primary outcome ‘living will’ and associated factors were identified for each person aged 65 or older from RAI-assessment data (Resident Assessment Instrument, RAI). Cross-tabulations with χ²-tests and adjusted binary logistic regression models were performed to evaluate the association between the factors and a living will. Results: Of the 10,178 participants, 21% had a living will – a greater proportion were female (22%) than male (18%), and a greater proportion of residents in assisted living (25%) and residential care homes (20%) compared with home care residents (15%) had a living will. Female gender ( p < 0.001), having a proxy decision-maker ( p = 0.001), increasing age ( p = 0.003), impairing functional capacity (activities of daily living hierarchy p < 0.001, Cognitive Performance Scale p < 0.001), instability of health status (Changes in Health, End-Stage Disease and Signs and Symptoms p < 0.001), and closeness of death ( p < 0.001) were significantly associated with a living will among older persons. Extensive differences in results were found between home care clients and clients of round-the-clock long-term care. Conclusion: Preparedness for the future with a living will varies according to services and on individual level. To reduce inequalities in end-of-life care, actions for advance care planning with appropriate timing are warranted.
Completing a genomic characterisation of microscopic tumour samples with copy number
Authors: Nulsen Joel , Hussain Nosheen , Al-Deka Aws , Yap Jason , Uddin Khalil , Yau Christopher , Ahmed Ahmed Ashour 
Published: November 2023

Abstract
Background
Genomic insights in settings where tumour sample sizes are limited to just hundreds or even tens of cells hold great clinical potential, but also present significant technical challenges. We previously developed the DigiPico sequencing platform to accurately identify somatic mutations from such samples.

Results
Here, we complete this genomic characterisation with copy number. We present a novel protocol, PicoCNV, to call allele-specific somatic copy number alterations from picogram quantities of tumour DNA. We find that PicoCNV provides exactly accurate copy number in 84% of the genome for even the smallest samples, and demonstrate its clinical potential in maintenance therapy.

Conclusions
PicoCNV complements our existing platform, allowing for accurate and comprehensive genomic characterisations of cancers in settings where only microscopic samples are available.
Fecal carriage of extended-spectrum β-lactamase-producing enterobacterales from hospitals and community settings in Gaza Strip, Palestine
Authors: El Aila Nabil Abdullah , Laham Nahed Ali Al , Ayesh Basim Mohammed , Naas Thierry 
Published: November 2023

Abstract
Background
The fecal carriage of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) is a major driver of the global spread of these antibiotic resistance determinants. Here we determined the rate of fecal ESBL-PE carriage in pediatric hospitals and community-serving healthcare centers serving adults and children in the Gaza Strip, Palestine.

Methods
A total of 373 fecal and rectal samples were collected from different hospitals and clinics in Gaza. The antibiotic susceptibility was determined using the disk diffusion method and interpreted according to CLSI guidelines. The bacterial isolates were tested for ESBL production using phenotypic methods (double disk synergy test and growth on selective chromogenic media). BlaCTX−M, blaSHV, and blaTEM genes were sought by PCR.

Results
Out of the 373 isolates tested, 138 (37%) were considered ESBL positive as revealed by phenotypic tests. The prevalence of ESBLs among hospitalized patients was 39.1% (hospital setting) whereas, among outpatients attending community healthcare centers, it was 35.1% (community setting). ESBL production among Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Proteus mirabilis, and Klebsiella aerogenes isolates was 52.8%, 39.1%, 26.7%, 2.8%, and 2.1% respectively. Meropenem and amikacin were the most effective antibiotics against ESBL producers (68.9% and 73.6% susceptibility, respectively), while only 15.2%, 22.5%, and 24.6% remained susceptible to ceftazidime, cefotaxime, and ceftriaxone, respectively. Out of 138 phenotypically ESBL-positive isolates, 98 randomly chosen were screened for blaCTX−M, blaTEM, and blaSHV genes. The prevalence rate of blaCTX−M was 45.9%, while blaTEM and blaSHV genes were detected in 16.8% and 5.2% of CTX-M-negative isolates (corresponding mostly for K. pneumoniae isolates in the case of SHV-PCR), respectively.

Conclusions
The study revealed an alarmingly high prevalence of fecal carriage of ESBL-producing Enterobacterales among hospitalized children but also in the community of the Gaza Strip. In addition, 30% of ESBL-producers were already resistant to carbapenems, the treatment of choice of infections with ESBL-producers.
Effect of the res2 transcription factor gene deletion on protein secretion and stress response in the hyperproducer strain Trichoderma reesei Rut-C30
Authors: Alharake Jawad , Bidard Frédérique , Aouam Thiziri , Sénamaud-Beaufort Catherine , Margeot Antoine , Heiss-Blanquet Senta 
Published: November 2023

Abstract
Background
The fungus Trichoderma reesei is one of the most used industrial cellulase producers due to its high capacity of protein secretion. Strains of T. reesei with enhanced protein secretion capacity, such as Rut-C30, have been obtained after several rounds of random mutagenesis. The strain was shown to possess an expanded endoplasmic reticulum, but the genetic factors responsible for this phenotype remain still unidentified. Recently, three new transcription factors were described in Neurospora crassa which were demonstrated to be involved in protein secretion. One of them, RES2, was involved in upregulation of secretion-related genes. The aim of our present study was therefore to analyze the role of RES2, on protein secretion in the T. reesei Rut-C30 strain.

Result
Deletion of the res2 gene in Rut-C30 resulted in slightly slower growth on all substrates tested, and lower germination rate as well as lower protein secretion compared to the parental strain Rut-C30. Transcriptomic analysis of the Rut-C30 and the Δres2 mutant strain in secretion stress conditions showed remarkably few differences : 971 genes were differentially expressed (DE) in both strains while 192 genes out of 1163 (~ 16.5%) were DE in Rut-C30 only and 693 out of 1664 genes (~ 41.6%) displayed differential expression solely in Δres2. Notably, induction of protein secretion by cultivating on lactose and addition of secretion stress inducer DTT induced many genes of the secretion pathway similarly in both strains. Among the differentially expressed genes, those coding for amino acid biosynthesis genes, transporters and genes involved in lipid metabolism were found to be enriched specifically in the Δres2 strain upon exposure to lactose or DTT. Besides, redox homeostasis and DNA repair genes were specifically upregulated in the Δres2 strain, indicating an altered stress response.

Conclusion
These results indicate that in the T. reesei Rut-C30 strain, RES2 does not act as a master regulator of the secretion pathway, but it contributes to a higher protein secretion by adjusting the expression of genes involved in different steps of protein synthesis and the secretion pathway.