bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric Comparison of Endoscopic Endonasal Transpterygoid and Precaruncular Contralateral Medial Transorbital Approaches to Sphenoid Sinus Lateral Recess
Authors: Bhuskute Govind S. , Gosal Jaskaran Singh , Alsavaf Mohammad Bilal , Abouammo Moataz D. , Manjila Sunil , Kandregula Sandeep , Nayyar Ashish K. , Jha Deepak K. , Carrau Ricardo L. , Prevedello Daniel M. 
Published: January 2024

BACKGROUND AND OBJECTIVES:
The endoscopic endonasal transpterygoid approach (TPA), minimally invasive compared with the sublabial transmaxillary and transcranial approaches, still accounts for morbidity in benign lateral recess of sphenoid sinus (LRSS) pathologies. Others have suggested an alternative route to the LRSS, the endoscopic contralateral medial transorbital approach (cMTO). However, no quantitative evidence exists to support the clinical application of this approach. This cadaveric study, in a controlled laboratory setting, provides a morphometric comparison of the TPA and cMTO for accessing the LRSS. The study also details the anatomy and technical nuances for optimizing the cMTO corridor.

METHODS:
Ten fresh preinjected human cadaveric specimens (20 sides) were dissected with neuronavigation, completing endoscopic cMTO and TPA on each side. Four parameters—working distance to lateral recess, surgical exposure area, angle of attack (AoA), and surgical freedom—were measured for each approach. Relevant osteological measurements in 10 dried human skulls were recorded.

RESULTS:
The mean distance from the superior margin of the lacrimal sac impression to the inferior margin of the trochlear fossa was 10.29 ± 1.13 mm, and that from the anterior ethmoidal artery foramina to the posterior lacrimal crest was 9.63 ± 1.23 mm. The mean exposure area around the LRSS was significantly higher in TPA (614.09 ± 40.38 mm2) than in cMTO (391.19 ± 59.01 mm2, P = .001). The mean AoA was 9.83° and 10.24° in the cMTO and TPA, respectively, in the craniocaudal direction (P = .529). In the horizontal plane, it was 9.29° and 10.76° (P = .012). There was no significant difference in surgical freedom between the cMTO and TPA (804.61 and 806.05 mm3, respectively; P = .993).

CONCLUSION:
Although comparatively limited exposure area, the cMTO approach has a similar AoA and surgical freedom as TPA and offers better visualization and ergonomic advantages. cMTO provides a feasible, less morbid, multiport technique for benign sphenoid sinus lateral recess pathologies.
Nasal Injuries and Issues in Athletes
Authors: Escalona Tomas , Okamura Anthony Robert 
Published: January 2024

Abstract
Nasal injuries and issues are widespread in athletic populations and can adversely affect training, performance, and overall well-being. Causes can typically be understood as cellular (allergic, nonallergic, and infectious rhinitis) or structural (static vs dynamic obstruction, trauma), and diagnosis and management differ accordingly. Upper respiratory tract infections, a subtype of infectious rhinitis, remain the most common illnesses among athletes. Here, the authors review the research surrounding the complex relationship between exercise, immunology, and susceptibility to infection. Furthermore, the authors provide an updated understanding of the current literature surrounding rhinitis and nasal trauma management and synthesize practical treatment considerations for providers caring for athletes at all levels.
Case Report: Management of pediatric Le Fort and mandibular fracture with a modified cap splint
Authors: Mathura Mrinalini , Bhola Nitin , Agarwal Anchal , Gupta Monica 
Published: January 2024

Pediatric facial fractures are rare and make up 5–15% of all facial fractures. The low incidence of facial fractures among children is due to physiological and environmental factors such as greater resilience of the pediatric skeleton, higher bone to tooth ratio, direct parental supervision and limited outdoor activity.1 In children of 5–10 years of age nasal fractures are by far the most frequent (58.6%), followed by mandibular fractures (21.5%). Orbital (9.5%), frontal (5.1%), and midfacial (3.8%) fractures are next in frequency2. Le Fort fractures are very rare in children, and there is a paucity of literature presenting their frequency and characteristics. In the mandible condylar fracture is the most common (38.9%) followed by angle (20.6%), parasymphysis (18.3%), body (15.3%) and symphysis (5.3%).3 Facial fractures are more common in boys, though this varies greatly from 1.1:1 to 8.5:1.4 The majority of facial fractures in children result from falls (7.8–48%) and sports-related injuries (4.4–42%).5 In primary or mixed dentition, the placement of internal fixation hardware is challenging due to the risk of injuring unerupted permanent tooth follicles. The use of resorbable plates and screws offer a potential solution to the growing pediatric facial bone as the standard titanium fixation systems carry the risk of translocation, growth restriction, and dental injury. Dental splinting or suspension wires can also be used in place of direct plating. Fortunately, mild malocclusion at this age has the potential to be improved through bony remodeling, the eruption of permanent dentition, compensation of the mastication mechanism, and posttraumatic orthodontia.6 Accordingly, the goal of treatment is to restore the underlying bony architecture to its preinjury position in a stable fashion with minimal residual functional and esthetic impairment.
A protocol for a comparative evaluation of the fracture resistance of endodontically treated teeth reinforced with Cention N, resin-modified glass ionomer cement (RMGIC) and short fiber reinforced flowable composite as an intraorifice barrier
Authors: Jidewar Namrata , Chandak Manoj 
Published: January 2024

Background: Endodontic treatment is the most common method for resolving pulpal and periapical pathology. However, various studies have reported that almost 11%–13% of all teeth that undergo extraction after endodontic treatment show the presence of cracks, craze lines, and vertical root fractures. Teeth with inadequate post endodontic restoration are more prone to fracture and coronal leakage, resulting in the diffusion of oral fluids, bacteria, bacterial products, and possibly root canal treatment failure. Furthermore, studies have advocated the use of endodontically treated teeth with restorative materials that have a similar or higher elastic modulus than the tooth for providing stiffness against forces that cause root fracture. Intraorifice barriers made of restorative materials that can bond to radicular dentin could thus be used to reinforce the radicular dentin while also preventing coronal microleakage. Although the sealing ability of intraorifice barriers has been widely compared in the literature, there have been few studies on the strengthening effect of the materials used in the study as intraorifice barriers when placed into the root canal. As a result, the current in vitro study aims to assess the effect of various materials as intraorifice barriers (Cention N, Resin modified glass ionomer cement, and short fiber reinforced flowable composite) on the force required fracture teeth after root canal treatment. Methods: This in vitro study will be done on extracted human mandibular premolars with single root canal where after doing root canal treatment 2-3 mm obturating material would be replaced by intra orifice barriers (Cention N, resin modified glass ionomer cement [RMGIC], and short fiber reinforced flowable composite). The force required to fracture teeth will be calculated using universal testing machine.
Evaluation for the efficacy of haemocoagulase agent (botroclot) as a pulpotomy material as compared to ferric sulfate- an animal study.
Authors: Karkare Swati , Thosar Nilima 
Published: January 2024

Deciduous teeth are thought to be best space maintainers; thus efforts are made to preserve these teeth for as long as possible. Grossly carious primary teeth should be restored and maintained which is the primary objective of “Pediatric dentistry”. Pulpotomy is done in the primary teeth where mechanical pulp exposure occurs during caries removal. All the functions of the radicular pulp are expected to be maintained by pulpotomy procedure. The main objectives are 1) managing reversible pulpal inflammation and keeping pulp in a vital condition. 2) maintain the function of the radicular pulp in deciduous teeth. Success of Pulpotomy procedure is dependent on many factors, and the ability of the pulpotomy medicament being hemostatic is one of the most vital factors to maintain the vitality of the radicular pulp. Considering the limitations of commonly used pulpotomy medicaments for primary teeth i.e. Formocresol and also the disadvantages associated with the hemostatic Ferric sulfate, the present study will be carried out using hemocoagulase (“botroclot”) which has shown improved hemocoagulant properties in the medical field and for healing the extraction socket wounds. The available solution of hemocoagulase agent converted in suitable Gel form will be tested for its tissue compatibility and hemocoagulant efficacy when used as pulpotomy material . The study will be conducted in two phases, I) Formulation of the gel and in vitro tests; II) Animal study to check histopathological effect on the pulp tissue as a pulpotomy agent.
Pelvic pain symptoms and endometriosis characteristics in relation to oxidative stress among adolescents and adults with and without surgically-confirmed endometriosis
Authors: Shafrir Amy L , Wallace Britani , Laliberte Ashley , Vitonis Allison F , Sieberg Christine B , Terry Kathryn L , Missmer Stacey A 
Published: January 2024

Background: While the majority of reproductive-aged females will experience pelvic pain during their lives, biological mechanisms underlying pelvic pain are not well understood. We investigated associations between pelvic pain symptoms and oxidative stress among people with and without surgically-confirmed endometriosis. Methods: Using an enzyme-linked immunosorbent assay, we measured 8-Hydroxy-2’-deoxyguanosine (8-OHdG) in urine samples and corrected for creatinine levels in 434 surgically-confirmed endometriosis participants compared to 605 participants never diagnosed with endometriosis. At enrollment, participants reported details of their pelvic pain symptoms. Linear regression was used to compute geometric mean (GM) creatinine-corrected 8-OHdG levels with 95% confidence intervals (CI) among all participants and those with and without endometriosis separately, adjusting for potential confounders. Interactions by surgically-confirmed endometriosis status were tested by Wald statistics. Results: No trends in 8-OHdG were observed among those with or without endometriosis for severity or frequency of dysmenorrhea, acyclic pelvic pain, dyspareunia or pain with bowel movements. Among endometriosis participants, lower 8-OHdG levels were observed for participants with any white, blue/black, or brown lesions (GM=76.7 versus 82.9 ng/mg; p=0.10), which was primarily driven by lower levels of 8-OHdG for any blue/black lesions (GM=72.8 versus 81.6 ng/mg; p=0.05). Conclusion: While no associations were observed between 8-OHdG and pelvic pain symptoms, future research is needed to assess how other pathways of oxidative damage, e.g. through proteins or lipids, may affect endometriosis-associated symptoms. Additionally, further research is needed to understand differences in oxidative stress among endometriosis lesion sub-phenotypes.
Modified pull-through delayed hand-sewn coloanal anastomosis after laparoscopic total mesorectal excision
Authors: Bendib Hani , Djelali Nabil , Oukrine Hind , Chekman Chemseddine , Anou Abdelkrim 
Published: January 2024

Background: Since its first description by Babcock in the 1930's, the pull-through delayed coloanal anastomosis (DCA) has lost interest in favor of the immediate coloanal anastomosis (ICA) with temporary stoma; especially with the advent of surgical stapling devices. In the last few years, there has been a renewed focus on DCA due to published favorable results, notably the reduced rate of anastomotic fistulas (AF) without the need for a stoma. Some authors have brought some modifications to the original technique. In this article, we describe the modified delayed coloanal anastomosis (mDCA) as it is performed in the Department of Oncologic Surgery at the Debussy Clinic. Methods: The mDCA consists on the one hand in shortening the pulled-through colonic stump, and on the other hand in performing a high anastomosis at the upper part of the anal canal. Results: This technique was successfully carried out in three patients with low rectal cancer. No AF was observed and diversion ileostomy was avoided in all patients. Conclusions: The mDCA is a feasible and safe approach for the treatment of rectal cancer by minimal invasive surgery.
Rationalizing Outcomes: Interdependent Learning in Competitive Markets
Authors: Menon Anoop , Yao Dennis 
Published: January 2024

In this article, we use simulation models to explore interdependent learning in competitive markets. Such interactions require attention to both the mental representations held by the management of the focal firm as well as the beliefs of that management about the representations held by rival management. When jointly determined outcomes are the primary input to the learning process, understanding rival beliefs—what we call strategic empathy—becomes a crucial factor driving performance. To illustrate these processes, we focus on mental representations that a manager has regarding market demand. In our simulation models, learning occurs through market observations, which recalibrate a manager’s representation about demand. But the flexibility allowed by this recalibration is also a way through which managers rationalize incorrect representations. We find these processes sometimes lead to distortions of initially correct representations and may result in superior relative performance by the firm whose manager holds less correct representations. Finally, we explore how superior knowledge of a rival’s demand representations can improve own performance through market actions that intentionally shape how a rival learns.Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2018.0083 .
Learning-Based Optimal Admission Control in a Single-Server Queuing System
Authors: Cohen Asaf , Subramanian Vijay , Zhang Yili 
Published: January 2024

We consider a long-term average profit–maximizing admission control problem in an M/M/1 queuing system with unknown service and arrival rates. With a fixed reward collected upon service completion and a cost per unit of time enforced on customers waiting in the queue, a dispatcher decides upon arrivals whether to admit the arriving customer or not based on the full history of observations of the queue length of the system. Naor [Naor P (1969) The regulation of queue size by levying tolls. Econometrica 37(1):15–24] shows that, if all the parameters of the model are known, then it is optimal to use a static threshold policy: admit if the queue length is less than a predetermined threshold and otherwise not. We propose a learning-based dispatching algorithm and characterize its regret with respect to optimal dispatch policies for the full-information model of Naor [Naor P (1969) The regulation of queue size by levying tolls. Econometrica 37(1):15–24]. We show that the algorithm achieves an O(1) regret when all optimal thresholds with full information are nonzero and achieves an [Formula: see text] regret for any specified [Formula: see text] in the case that an optimal threshold with full information is 0 (i.e., an optimal policy is to reject all arrivals), where N is the number of arrivals. Funding: A. Cohen is partially supported by the National Science Foundation [Grant DMS-2006305]. V. Subramanian is supported in part by the NSF [Grants CCF-2008130, ECCS-2038416, CNS-1955777, and CMMI-2240981].
Unveiling out-of-loop attosecond timing jitter precision in Ti:sapphire mode-locked lasers with an optical heterodyne technique
Authors: Wu Haitao , Xu Hao , Zhao Jianye 
Published: January 2024

The out-of-loop timing jitter exhibited in free-running Ti:sapphire mode-locked lasers with attosecond resolution is demonstrated using an optical heterodyne technique. To assess the feasibility of the experiment and discrimination signal properties, numerical simulations were conducted for Ti:sapphire mode-locked lasers. For accurately characterizing the genuine phase noise exhibited by Ti:sapphire mode-locked lasers, out-of-loop measurements were conducted, and a straightforward yet improved optical heterodyne setup was employed, allowing simultaneous low-bandwidth locking and out-of-loop timing jitter measurements with two Ti:sapphire mode-locked lasers. The out-of-loop phase noise floor for a single mode-locked laser reaches −203.47 dBc/Hz, assuming a 10 GHz carrier frequency. Additionally, the out-of-loop integrated timing jitter is 11.9 as from 10 kHz to the Nyquist frequency (50 MHz).
Reusable rule-based cell cycle model explains compartment-resolved dynamics of 16 observables in RPE-1 cells
Authors: Lang Paul F. , Penas David R. , Banga Julio R. , Weindl Daniel , Novak Bela 
Published: January 2024

The mammalian cell cycle is regulated by a well-studied but complex biochemical reaction system. Computational models provide a particularly systematic and systemic description of the mechanisms governing mammalian cell cycle control. By combining both state-of-the-art multiplexed experimental methods and powerful computational tools, this work aims at improving on these models along four dimensions: model structure, validation data, validation methodology and model reusability.
We developed a comprehensive model structure of the full cell cycle that qualitatively explains the behaviour of human retinal pigment epithelial-1 cells. To estimate the model parameters, time courses of eight cell cycle regulators in two compartments were reconstructed from single cell snapshot measurements. After optimisation with a parallel global optimisation metaheuristic we obtained excellent agreements between simulations and measurements. The PEtab specification of the optimisation problem facilitates reuse of model, data and/or optimisation results.
Future perturbation experiments will improve parameter identifiability and allow for testing model predictive power. Such a predictive model may aid in drug discovery for cell cycle-related disorders.
A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway
Authors: Song Yan Yan , Zhang Xin Zhuo , Wang Bo Ning , Cheng Yong Kang , Guo Xin , Zhang Xi , Long Shao Rong , Liu Ruo Dan , Wang Zhong Quan , Cui Jing 
Published: January 2024

Background
Gut epithelium is the first natural barrier against Trichinella spiralis larval invasion, but the mechanism by which larval penetration of gut epithelium is not completely elucidated. Previous studies showed that proteases secreted by T. spiralis intestinal infective larvae (IIL) degraded tight junctions (TJs) proteins of gut epithelium and mediated larval invasion. A new T. spiralis serine proteinase (TsSPc) was identified in the IIL surface proteins and ES proteins, rTsSPc bound to the intestinal epithelial cell (IECs) and promoted larval invasion of IECs. The aim of this study was to characterize the interacted proteins of TsSPc and IECs, and to investigate the molecular mechanisms of TsSPc mediating larval invasion of gut mucosa.

Methodology/Principal finding
IIFT results showed natural TsSPc was detected in infected murine intestine at 6, 12 hours post infection (hpi) and 3 dpi. The results of GST pull-down, mass spectrometry (MS) and Co-IP indicated that rTsSPc bound and interacted specifically with receptor for activated protein C kinase 1 (RACK1) in Caco-2 cells. rTsSPc did not directly hydrolyze the TJs proteins. qPCR and Western blot showed that rTsSPc up-regulated RACK1 expression, activated MAPK/ERK1/2 pathway, reduced the expression levels of gut TJs (occludin and claudin-1) and adherent protein E-cad, increased the paracellular permeability and damaged the integrity of intestinal epithelial barrier. Moreover, the RACK1 inhibitor HO and ERK1/2 pathway inhibitor PD98059 abolished the rTsSPc activating ERK1/2 pathway, they also inhibited and abrogated the rTsSPc down-regulating expression of occludin, claudin-1 and E-cad in Caco-2 monolayer and infected murine intestine, impeded larval invasion and improved intestinal epithelial integrity and barrier function, reduced intestinal worm burdens and alleviated intestinal inflammation.

Conclusions
rTsSPc bound to RACK1 receptor in gut epithelium, activated MAPK/ERK1/2 pathway, decreased the expression of gut epithelial TJs proteins and disrupted the epithelial integrity, consequently mediated T. spiralis larval invasion of gut epithelium. The results are valuable to understand T. spiralis invasion mechanism, and TsSPc might be regarded as a vaccine target against T. spiralis invasion and infection.
What risk do Brucella vaccines pose to humans? A systematic review of the scientific literature on occupational exposure
Authors: Vives-Soto Manuel , Puerta-García Amparo , Rodríguez-Sánchez Esteban , Pereira José-Luis , Solera Javier 
Published: January 2024

Background
Currently, vaccination of livestock with attenuated strains of Brucella remains an essential measure for controlling brucellosis, although these vaccines may be dangerous to humans. The aim of this study was to review the risk posed to humans by occupational exposure to vaccine strains and the measures that should be implemented to minimize this risk.

Methods
This article reviewed the scientific literature indexed in PubMed up to September 30, 2023, following "the PRISMA guidelines". Special emphasis was placed on the vaccine strain used and the route of exposure. Non-occupational exposure to vaccine strains, intentional human inoculation, publications on exposure to wild strains, and secondary scientific sources were excluded from the study.

Results
Nineteen primary reports were found and classified in three subgroups: safety accidents in vaccine factories that led to an outbreak (n = 2), survellaince studies on vaccine manufacturing workers with a serologic diagnosis of Brucella infection (n = 3), and publications of infection by vaccine strains during their administration, including case reports, records of occupational accidents and investigations of outbreaks in vaccination campaigns (n = 14). Although accidental exposure during vaccine manufacturing were uncommon, they could provoke large outbreaks through airborne spread with risk of spread to the neighboring population. Besides, despite strict protection measures, a percentage of vaccine manufacturing workers developed positive Brucella serology without clinical infection. The most frequent type of exposure with symptomatic infection was needle injury during vaccine administration. Prolonged contact with the pathogen, lack of information and a low adherence to personal protective equipment (PPE) use in the work environment were commonly associated with infection.

Conclusions
Brucella vaccines pose occupational risk of contagion to humans from their production to their administration to livestock, although morbidity is low and deaths were not reported. Recommended protective measures and active surveillance of exposed workers appeared to reduce this risk. It would be advisable to carry out observational studies and/or systematic registries using solid diagnostic criteria.