bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous intervention for the treatment of hypoplastic aortoiliac syndrome
Authors: Walton Brian L. , Dougherty Kathy , Mortazavi Ali , Strickman Neil , Krajcer Zvonimir 
Published: October 2003

AbstractHypoplastic aortoiliac syndrome (HAIS) occurs in young women and is characterized by a small infrarenal aorta with a hypoplastic iliofemoral arterial system and advanced atherosclerotic disease. Of 304 aortoiliac interventions (AoI), 30 female patients (mean age, 50 ± 5 years) had HAIS. HAIS patients were less likely to have coronary disease (33% vs. 88%; P < 0.0001) or diabetes (10% vs. 42%; P < 0.001) compared to their AoI counterparts. Twenty‐three patients (73%) had hyperlipidemia with mean cholesterol of 287 ± 42 mg/dl. Twenty‐eight patients (93%) were successfully treated with AoI. The ankle/brachial indices improved from pre‐AoI ABI of 0.55 ± 0.1 to post‐AoI ABI of 0.99 ± 0.1. Complications included one groin hematoma and one case of thrombosis. Follow‐up averaged 31 months (range, 3–91 months) with an early (less than 12 months) restenosis rate of 7% and late (greater than 12 months) restenosis of 21%. One patient (3%) required surgical revascularization for persistent symptoms. Percutaneous treatment of HAIS is an alternative to surgical revascularization with satisfactory long‐term results.Catheter Cardiovasc Interv 2003;60:329–334. © 2003 Wiley‐Liss, Inc.
Stenting and glycoprotein IIb/IIIa inhibition in patients with acute myocardial infarction undergoing percutaneous coronary intervention: Findings from the global registry of acute coronary events (GRACE)
Authors: Montalescot Gilles , Van de Werf Frans , Gulba Dietrich C. , Avezum Álvaro , Brieger David , Kennelly Brian M. , Mazurek Tomasz , Spencer Frederick , White Kami , Gore Joel M. 
Published: October 2003

AbstractStenting and GP IIb/IIIa inhibition are promising adjunctive therapies in PCI. The Global Registry of Acute Coronary Events (GRACE) is a registry of unselected patients with acute coronary syndromes, allowing for the study of treatments in a real‐world environment. Data from GRACE patients with AMI who underwent PCI were analyzed. After adjusting for demographics, baseline characteristics, and previous medications, treatment with GP IIb/IIIa inhibitors and a stent and treatment with a stent alone were significant predictors of survival at 6 months. Stents were used in 90.9% of patients. GP IIb/IIIa inhibitors were used in 59.7%; in most cases they were started after the beginning of the procedure. The in‐hospital death rate (7.6%) was highest in patients undergoing urgent PCI. Mortality at 6 months following PCI was 14.4% among patients who received neither GP IIb/IIIa inhibitors nor a stent, compared to patients who received both GP IIb/IIIa inhibitors and a stent (7.3%), GP IIb/IIIa inhibitors alone (12.8%), or a stent alone (6.7%) Catheter Cardiovasc Interv 2003;60:360–367. © 2003 Wiley‐Liss, Inc.
Clinical impact of abciximab on long‐term outcome after complex coronary angioplasty
Authors: Wijpkema Jasper S. , Jessurun Gillian A.J. , Van Boven Ad J. , Versteeg Dik I.K. , Hautvast Raymond W.M. , Tio René A. 
Published: October 2003

AbstractGlycoprotein IIb/IIIa receptor antagonists, such as abciximab, are used to reduce major adverse cardiac events (MACEs) in patients undergoing percutaneous transluminal coronary angioplasty. The goal of this study was to evaluate the administration of abciximab in relation to lesion complexity and periprocedural complications. A total of 357 patients with 435 de novo lesions were included in this study. Lesions were divided into simple (type A and type B1) and complex (type B2 and type C) lesions according to the American College of Cardiology/American Heart Association Task Force lesion complexity system. Abciximab was given to unstable complex lesions and simple lesions with a periprocedural unstable complicated course. The overall incidence of MACE during the 9‐month follow‐up period was 17.0%. Patients treated with abciximab had a higher lesion complexity (P < 0.001), dissections (P = 0.014), stents (P < 0.001), and vessels involved (P < 0.001). in addition, the abciximab group was characterized by a higher angina NYHA class (P = 0.005), lower TIMI flow prior to stenting (P = 0.01), and a longer total inflation time (P = 0.006). Despite these clinical differences, the occurrence of MACE within the abciximab group was slightly less than in the group without abciximab (16.2% and 17.3%, respectively). Lesion complexity was directly related to MACE in the group that did not receive abciximab (simple and stable complex lesions; P = 0.04). On the other hand, in subjects treated with abciximab, lesion complexity was not related to a higher incidence of MACE (P = 0.76). The use of abciximab equalizes the difference in outcome between simple and complex lesions. Therefore, abciximab should be advocated especially in unstable and complex percutaneous coronary interventions. Catheter Cardiovasc Interv 2003;60:339–343. © 2003 Wiley‐Liss, Inc.
Endovascular intervention of aortoiliac occlusive disease in high‐risk patients using the kissing stents technique: Long‐term results
Authors: Mouanoutoua Mouatou , Maddikunta Rajesh , Allaqaband Suhail , Gupta Anjan , Shalev Yoseph , Tumuluri Ramagopal , Bajwa Tanvir 
Published: October 2003

AbstractEndovascular intervention deploying a kissing stents (KS) technique has been used as an alternative to surgical intervention in treating symptomatic aortoiliac occlusive disease. However, the long‐term results on high‐risk patients are unknown. We retrospectively analyzed data on high‐risk patients who underwent endovascular intervention using the KS technique at our institution. Fifty high‐risk patients aged 62 ± 6.4 years with severe aortoiliac stenosis underwent stent‐supported angioplasty using the KS technique. Thirty percent of the patients had total occlusion of the distal aorta and/or the iliac arteries. Twelve patients received thrombolytics prior to stenting. The procedure was successful in all 50 patients. There was a 4% acute complication rate (distal embolization). However, there were no vascular complications, myocardial infarction, or perioperative death. Primary patency during follow‐up of 20 ± 12.3 months was 92%, while secondary patency rate was 100%. Amputation‐free survival was 100%. Ninety‐two percent remained free of lifestyle‐limiting claudication.Catheter Cardiovasc Interv 2003;60:320–326.© 2003 Wiley‐Liss, Inc.
Transcatheter left atrial appendage occlusion with Amplatzer devices to obviate anticoagulation in patients with atrial fibrillation
Authors: Meier Bernhard , Palacios Igor , Windecker Stephan , Rotter Martin , Cao Qi‐Ling , Keane David , Ruiz Carlos E. , Hijazi Ziyad M. 
Published: October 2003

AbstractIt is assumed that over 90% of clinically apparent embolisms in atrial fibrillation originate from the left atrial appendage. Recently, a percutaneous method (PLAATO technique) to occlude the left atrial appendage to the end of preventing thromboembolic complications of atrial fibrillation has been introduced into clinical practice. This technique is quite intricate and requires general anesthesia. The Amplatzer atrial septal occluder lends itself for a more simple approach to this intervention. The first 16 patients treated at four centers are described. Their age varied from 58 to 83 years. All suffered from atrial fibrillation but eight of them were in sinus rhythm at the time of implantation. All but two procedures were done under local anesthesia of the groin only. There was one technical failure (device embolization) requiring surgery. All other patients left the hospital a day after the procedure without complications. There were no problems or embolic events during an overall follow‐up of 5 patient‐years and all left atrial appendages were completely occluded without evidence of thrombosis at the atrial side of the device at the latest follow‐up echocardiography. With the Amplatzer technique, the left atrial appendage can be percutaneously occluded with a venous puncture under local anesthesia, without echocardiographic guidance, and at a reasonable risk. It remains to be evaluated in larger series or randomized trials how the simpler Amplatzer technique compares with the complex PLAATO technique, and whether left atrial appendage closure is competitive with oral anticoagulation with warfarin or the novel ximelagatran to prevent thromboembolism in atrial fibrillation. Catheter Cardiovasc Interv 2003;60:417–422. © 2003 Wiley‐Liss, Inc.
Synergistic effects of a novel nanoporous stent coating and tacrolimus on intima proliferation in rabbits
Authors: Wieneke Heinrich , Dirsch Olaf , Sawitowski Thomas , Gu Yan Li , Brauer Holger , Dahmen Uta , Fischer Alfons , Wnendt Stefan , Erbel Raimund 
Published: October 2003

AbstractTo overcome the problem of in‐stent restenosis, the concept of local delivery of antiproliferative or immunosuppressive drugs has been introduced into interventional cardiology. Local drug delivery can be achieved by drug‐eluting stents coated with polymer surfaces used for controlled drug release. However, several polymer coatings have shown an induction of inflammatory response and increased neointima formation. In the present study, the effect of a new inorganic ceramic nanoporous aluminum oxide (Al2O3) coating on neointima proliferation and its suitability as a carrier for the immunosuppressive drug tacrolimus have been investigated. 316 L stainless steel coronary stents were coated with a 500 nm thin nanoporous aluminum oxide layer. This ceramic nanolayer was used as a carrier for tacrolimus. Bare stents (n = 6), ceramic coated stents (n = 6), and ceramic coated stents loaded with 60 (n = 7) and 120 μg (n = 6) tacrolimus were implanted in the common carotid artery of New Zealand rabbits. The ceramic coating caused no significant reduction of neointimal thickness after 28 days. Loading the ceramic stents with tacrolimus led to a significant reduction of neointima thickness by 52% for 60 μg (P = 0.047) and 56% for 120 μg (P = 0.036) as compared to the bare stents. The ceramic coating alone as well as in combination with tacrolimus led to a reduced infiltration of lymphocytes and macrophages in the intima in response to stent implantation. Ceramic coating of coronary stents with a nanoporous layer of aluminum oxide in combination with tacrolimus resulted in a significant reduction in neointima formation and inflammatory response. The synergistic effects of the ceramic coating and tacrolimus suggest that this new approach may have a high potential to translate into clinical benefit. Catheter Cardiovasc Interv 2003;60:399–407. © 2003 Wiley‐Liss, Inc.
Incidence and predictors of late total occlusion following coronary stenting
Authors: Shah Pinak B. , Cutlip Donald E. , Popma Jeffrey J. , Kuntz Richard E. , Ho Kalon K.L. 
Published: October 2003

AbstractTo determine the incidence and predictors of total occlusion in‐stent restenosis, we reviewed three randomized stent vs. stent trials and one stent registry, which provided 955 coronary artery lesions with 6‐month angiographic follow‐up. Fifteen (1.6%) of the 955 stented lesions were totally occluded at 6‐month follow‐up. Most patients with total occlusion presented with recurrent angina at the time of repeat angiography (60.0%) while no patient presented with an acute ST segment elevation myocardial infarction. The univariate predictors of total occlusion following elective coronary stenting included stenting for restenosis after a previous percutaneous intervention (P = 0.001), longer stent length (P < 0.001), longer lesion length (P < 0.001), smaller reference vessel diameter (P = 0.022), smaller preprocedure minimum lumen diameter (MLD; P = 0.004), and smaller postprocedure MLD (P = 0.036). Stepwise multiple logistic regression analysis demonstrated that stenting for restenotic lesions (P = 0.004), longer stent length (P < 0.001), and smaller preprocedure MLD (P = 0.012) were independent predictors of total occlusion following coronary stenting. Catheter Cardiovasc Interv 2003;60:344‐351. © 2003 Wiley‐Liss, Inc.
Stenting for spontaneous left internal mammary artery dissection: A case report
Authors: Ziaee Ali , Puri Sanjeev , Kern Morton J. 
Published: October 2003

AbstractWe present a case of a spontaneously occurring mid LIMA dissection found on routine cardiac catheterization. We report our evaluation and intervention for this exceedingly rare phenomenon. Catheter Cardiovasc Interv 2003;60:389–391. © 2003 Wiley‐Liss, Inc.
Direct stent implantation without predilatation through 5 French guiding catheter following transfemoral coronary angiogram: A feasibility study
Authors: Brasselet Camille , Metz Damien , Pérotin Sophie , Mangina Sophie Tassan , Deschildre Alain , Maillier Bruno , Blaise Claude , Elaerts Jacques 
Published: October 2003

AbstractDirect stenting (DS) is accepted as reducing procedural cost and duration and 5 Fr guiding catheters as lowering peripheral vascular complications. We aimed to evaluate the feasibility and safety of both strategies. We retrospectively studied 150 consecutive patients treated with DS strategy using a 5 Fr femoral approach. A need for 6 Fr devices or balloon predilatation defined 5 Fr DS failure. Procedural success was defined as good angiographic result (residual stenosis < 30% and TIMI flow 3) without ischemic complications. A total of 161 out of 174 lesions were elected as suitable for DS. The success rate of 5 Fr DS was 87.6% (141/161 lesions). The procedural success rate was 92% (138/150 patients). The angiographic success rate was 96.3% (155/161 lesions). Other complications were six non‐Q‐wave MI and one repeat angioplasty for acute in‐stent thrombosis. Only one major peripheral vascular complication occurred. Direct stenting through 5 Fr guiding catheters in selected lesions is safe and effective with a low incidence of peripheral arterial complications. Catheter Cardiovasc Interv 2003;60:354–359. © 2003 Wiley‐Liss, Inc.
Renal angioplasty and stenting under protection: The way for the future?
Authors: Henry Michel , Henry Isabelle , Klonaris Christos , Polydorou Antonio , Rath Pathrap , Lakshmi Gopalakrishnan , Rajacopal Sriram , Hugel Michèle 
Published: October 2003

AbstractThe purpose of this study was to evaluate the feasibility and safety of renal artery angioplasty and stenting utilizing a distal protection device to reduce the risk of intraprocedural artery embolism and avoid deterioration of the renal function. Fifty‐six hypertensive patients (32 men; mean age, 66 ± 11.8 years; range, 22–87) with atherosclerotic renal artery stenosis (8 bilateral) underwent angioplasty and stenting with distal protection in 65 renal arteries (58 ostial lesions). Five patients had a solitary kidney, 18 a renal insufficiency. The lesion was crossed either with a GuardWire temporary occlusion balloon (n = 38), which was inflated to provide parenchyma protection or with a filter (EPI Filter; n = 26), or with Angioguard (n = 1), which allows a continuous flow. Generated debris was aspirated and analyzed. Blood pressure and serum creatinine levels were followed. Immediate technical success was 100%. All lesions except one were stented, either directly (43 ostial lesions) or after predilatation (22 ostial lesions). Visible debris were aspirated with the PercuSurge in all patients or removed with filters in 80% of the patients. Mean particle number and diameter were 98.1 ± 60.0 per procedure (range, 13–208) and 201.0 ± 76.0 μm (range, 38–6,206), respectively. Mean renal artery occlusion time was 6.55 ± 2.46 min (range, 2.29–13.21) with the PercuSurge device. Mean time in situ (filters) was 4.25 ± 1.12 min. Mean follow‐up was 22.6 ± 17.6 months (range, 1–47). Systolic and diastolic blood pressure declined from 169.0 ± 15.2 and 104.0 ± 13.0 mm Hg, respectively, to 149.7 ± 12.4 and 92.7 ± 6.7 mm Hg after the procedure. The mean creatinine level remains constant during the follow‐up. At 6‐month follow‐up (45 patients), renal function did not deteriorate in any patient, whereas 8 patients with baseline renal insufficiency improved after the procedure. At 3 years (19 patients), renal function deteriorated only in 1 patient with renal insufficiency and in 1 patient treated for bilateral renal stenosis, one side without protection. These preliminary results suggest the feasibility and safety of distal protection during renal interventions to protect against atheroembolism and to avoid renal function deterioration. This technique's beneficial effects should be evaluated by randomized studies. Catheter Cardiovasc Interv 2003;60:299–312. © 2003 Wiley‐Liss, Inc.
Forensische Chemie — Aufklärung von Verbrechen mit chemischen Methoden
Authors: Bader Hans Joachim , Rothweil Martin 
Published: October 2003

AbstractBei der Aufklärung von Verbrechen, besonders bei der Sicherung und dem Nachweis von Spuren, finden chemische und physikalische Verfahren eine breite Anwendung. Im Chemieunterricht lassen sich einige dieser Verfahren mit vergleichsweise geringem Aufwand nachvollziehen. Es werden hier Methoden zum Nachweis von Fingerabdrücken und Prägespuren vorgestellt.
Didaktische Überlegungen zur Implementierung diffusionsgesteuerter Wachstumsphänomene in den Chemieunterricht
Authors: Höltkemeier Dirk , Oetken Marco 
Published: October 2003

AbstractUNTER BESTIMMTEN BEDINGUNGEN wachsen bei dem Gefrieren von Wasser, der Kristallisation von Salzen aus übersättigten Salz‐Lösungen und der Fällung von Metallen durch Reduktion aus Metallsalz‐Lösungen dendritische, d.h. baumartig verzweigte Kristalle. Das Modell des diffusions‐kontrollierten Wachstums (engl. diffusion‐limited aggregation, DLA) führt dieses Phänomen auf eine ungerichtete Diffusionsbewegung von Teilchen und ihrer gesetzmäßigen Anlagerung bei dem Kontakt mit einem Wachstumskeim zurück. In diesem Beitrag wird nun aufgezeigt, dass eine Thematisierung derartiger diffusionskontrollierter Wachstumsphänomene im Chemieunterricht eine ungewöhnlichen Möglichkeit bietet, das Wechselspiel zwischen den charakteristischen Betrachtungsebenen der Chemie (makroskopische, submikroskopische und symbolische Ebene), dem so genannten „chemischen Dreieck”︁, bewusst zu machen und das Zusammensetzen der unterschiedlichen Perspektiven zu einem einheitlichen Bild zu üben. Das DLA‐Modell, das grundlegende Aspekte einer schulisch relevanten Diskontinuumsebene benutzt, spielt hierfür eine zentrale Rolle und es ermöglicht, die Morphologie und den Wachstumsprozess der dendritischen Kristalle in einem dynamischen Teilchenmodell interpretieren zu können.
Regulation of the transition from vimentin to neurofilaments during neuronal differentiation
Authors: Yabe Jason T. , Chan Walter K.‐H. , Wang Feng‐Song , Pimenta Aurea , Ortiz Daniela D. , Shea Thomas B. 
Published: October 2003

AbstractVimentin (Vm) is initially expressed by nearly all neuronal precursors in vivo, and is replaced by neurofilaments (NFs) shortly after the immature neurons become post‐mitotic. Both Vm and NFs can be transiently detected within the same neurite, and Vm is essential for neuritogenesis at least in culture. How neurons effect the orderly transition from expression of Vm as their predominant intermediate filament to NFs remains unclear. We examined this phenomenon within growing axonal neurites of NB2a/d1 cells. Transfection of cells with a construct expressing Vm conjugated to green fluorescent protein confirmed that axonal transport machinery for Vm persisted following the developmental decrease in Vm, but that the amount undergoing transport decreased in parallel to the observed developmental increase in NF transport. Immunoprecipitation from pulse‐chase radiolabeled cells demonstrated transient co‐precipitation of newly synthesized NF‐H with Vm, followed by increasing co‐precipitation with NF‐L. Immunofluorescent and immuno‐electron microscopic analyses demonstrated that some NF and Vm subunits were incorporated into the same filamentous profiles, but that Vm was excluded from the longitudinally‐oriented “bundle” of closely‐apposed NFs that accumulates within developing axons and is known to undergo slower turnover than individual NFs. These data collectively suggest that developing neurons are able to replace their Vm‐rich cytoskeleton with one rich in NFs simply by down‐regulation of Vm expression and upregulation of NFs, coupled with turnover of existing Vm filaments and Vm‐NF heteropolymers. Cell Motil. Cytoskeleton 56:193–205, 2003. © 2003 Wiley‐Liss, Inc.
3‐D surface charges modulate protrusive and contractile contacts of chondrosarcoma cells
Authors: Vautier Dominique , Hemmerlé Joseph , Vodouhe Constant , Koenig Géraldine , Richert Ludovic , Picart Catherine , Voegel Jean‐Claude , Debry Christian , Chluba Johanna , Ogier Joëlle 
Published: October 2003

AbstractUp to now, most of the studies addressing the critical roles played by protrusive and contractile cell‐matrix contacts in cell adhesion, guidance, migration, matrix assembly, and activation of signaling molecules have been performed on two‐dimensional surfaces. Here, we analysed the organization of chondrosarcoma cell contacts in a new three‐dimensional environment made of titanium beads. Surface charges were modified by deposition of polyelectrolyte multilayer films built up by alternated polycations poly‐(L‐lysine) or poly(allylamine hydrochloride) and polyanions poly‐(L‐glutamic acid) or poly(sodium 4‐styrenesulfonate). Negatively charged 3‐D titanium surfaces amplified the occurrence and length of cell protrusions. These protrusions had pseudopod characteristics extended to 200 μm in length, growing off the substratum to distant beads. Pseudopod formation is inhibited by the exocytosis inhibitor concanamycin A and is triggered by a secreted factor. Chondrosarcoma cells adhering on uncoated or on negatively charged surfaces contained discrete focal spots of vinculin and actin cables. In cells plated onto these surfaces, phosphorylation of p44/42 MAPK/ERK was twofold increased. In contrast, no cytoskeletal vinculin and actin organization was observed when the surface was positively charged. These data suggest that chondrosarcoma cells adapt a more stable adhesion on uncoated or negatively charged surfaces. This point may be critical in tissue engineering strategies designed for cartilage repair. Cell Motil. Cytoskeleton 56:147–158, 2003. © 2003 Wiley‐Liss, Inc.
A top down description of S‐CIELAB and CIEDE2000
Authors: Johnson Garrett M. , Fairchild Mark D. 
Published: October 2003

AbstractRecent work in color difference has led to the recommendation of CIEDE2000 for use as an industrial color difference equation. While CIEDE2000 was designed for predicting the visual difference for large isolated patches, it is often desired to determine the perceived difference of color images. The CIE TC8‐02 has been formed to examine these differences. This paper presents an overview of spatial filtering combined with CIEDE2000, to assist TC8‐02 in the evaluation and implementation of an image color difference metric. Based on the S‐CIELAB spatial extension, the objective is to provide a single reference for researchers desiring to utilize this technique. A general overview of how S‐CIELAB functions, as well as a comparison between spatial domain and frequency domain filtering is provided. A reference comparison between three CIE recommended color difference formulae is also provided. © 2003 Wiley Periodicals, Inc. Col Res Appl, 28, 425–435, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.10195