bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated guidance and control design by active disturbance rejection method for high-velocity target interceptor with DCS thruster
Authors: Chitsaz Ali , Naghash Abolghasem , Saberi Farhad Fani 
Published: January 2024

AbstractThe present paper proposes a novel integrated guidance and control (IGC) method for engaging with high-speed targets such as ballistic projectiles. considering an extreme short period of terminal engagement due to high relative velocity between target and interceptor, it is particularly important for IGC law to show desirable performance in the presence of various uncertainties (e.g. variation in aerodynamic coefficients) and disturbances (e.g. target maneuver and drag). This article extends the ICG law for mismatched and feedback form equations based on the Active Disturbance Rejection Control (ADRC) method using the back-stepping technique and the Reduced-order Extended State Observer (RESO). The primary consideration is the application of thrusters on the center of mass as the Divert Control System (DCS), along with the daisy-chain technique for control allocation between the fins and thruster commands. Contrary to previous research, the filter and angle measurement error are modeled for the seeker as a crucial parameter to highlight the significance of the thruster. The simulation results indicate the efficiency of the developed method for near-miss or hit-to-kill engagement with tactical ballistic targets. It is shown that the thruster plays a significant role in high-altitude engagements, specifically in the presence of non-ideal seeker. Finally, using the Monte Carlo simulation, it is proved that adding inner loops to the developed technique will not remove the IGC’s advantage over the conventional approach and Non-singular Terminal Sliding Mode (NTSM) guidance law.
In vitro influence of PEG functionalized ZnO–CuO nanocomposites on bacterial growth
Authors: Jayanetti Madara , Thambiliyagodage Charitha , Liyanaarachchi Heshan , Ekanayake Geethma , Mendis Amavin , Usgodaarachchi Leshan 
Published: January 2024

AbstractPolyethyleneglycol-coated biocompatible CuO–ZnO nanocomposites were fabricated hydrothermally varying Zn:Cu ratios as 1:1, 2:1, and 1:2, and their antibacterial activity was determined through the well diffusion method against the Gram-negative Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and the Gram-positive Staphylococcus aureus. The minimum inhibitory concentration and the minimum bactericidal concentration values of the synthesized samples were determined. Subsequently, the time synergy kill assay was performed to elucidate the nature of the overall inhibitory effect against the aforementioned bacterial species. The mean zone of inhibition values for all four samples are presented. The inhibitory effect increased with increasing concentration of the nanocomposite (20, 40 and 60 mg/ml) on all the bacterial species except for S. aureus. According to the MBC/MIC ratio, ZnO was found to be bacteriostatic for E. coli and P. aeruginosa, and bactericidal for S. aureus and K. pneumoniae. Zn:Cu 2:1 was bactericidal on all bacterial species. A bacteriostatic effect was observed on E. coli and P. aeruginosa in the presence of Zn:Cu 1:1 whereas, it showed a bactericidal effect on S. aureus and K. pneumoniae. Zn:Cu 1:2 exhibited a bacteriostatic effect on E. coli while a bactericidal effect was observed for E. coli, P. aeruginosa, and K. pneumoniae. The metal oxide nanocomposites were found to be more sensitive towards the Gram-positive strain than the Gram-negative strains. Further, all the nanocomposites possess anti-oxidant activity as shown by the DPPH assay.
A lightweight smart contracts framework for blockchain‐based secure communication in smart grid applications
Authors: Faheem Muhammad , Kuusniemi Heidi , Eltahawy Bahaa , Bhutta Muhammad Shoaib , Raza Basit 
Published: January 2024

AbstractEnergy is a crucial need in today's world for powering homes, businesses, transportation, and industrial processes. Fossil fuels, such as oil, coal, and natural gas, have been the primary sources of energy for decades. However, there is growing recognition of the negative environmental impact of fossil fuels and the need to transition to cleaner and more sustainable sources of energy. Distributed Energy Resources , such as wind and solar offer several benefits including, reducing energy costs, increasing resiliency, and decreasing carbon emissions. However, the integration of () into the grid requires advanced communication and secure control strategies to ensure a stable and reliable grid operations. In this regard, a blockchain‐based industrial wireless sensor network can provide secure and resilience data transmission to facilitate intelligent integration, monitoring, and control of in the smart grid. In this research, a smart contracts framework in Solana called Advanced Solana Blockchain () is proposed for in the smart grid. The proposed scheme enables resilient and secure real‐time control and monitoring of in smart grids. The performance evaluations and security analysis illustrated that this scheme is secure, reliable, and suitable in terms of lightweight data sharing between in smart grids.
Pre‐insertion resistors temperature prediction based on improved WOA‐SVR
Authors: Dai Honghe , Mo Site , Wang Haoxin , Yin Nan , Fan Songhai , Li Bixiong 
Published: January 2024

AbstractThe pre‐insertion resistors (PIR) within high‐voltage circuit breakers are critical components and warm up by generating Joule heat when an electric current flows through them. Elevated temperature can lead to temporary closure failure and, in severe cases, the rupture of PIR. To accurately predict the temperature of PIR, this study combines finite element simulation techniques with Support Vector Regression (SVR) optimized by an Improved Whale Optimization Algorithm (IWOA) approach. The IWOA includes Tent mapping, a convergence factor based on the sigmoid function, and the Ornstein–Uhlenbeck variation strategy. The IWOA‐SVR model is compared with the SSA‐SVR and WOA‐SVR. The results reveal that the prediction accuracies of the IWOA‐SVR model were 90.2% and 81.5% (above 100°C) in the ± 3°C temperature deviation range and 96.3% and 93.4% (above 100°C) in the ± 4°C temperature deviation range, surpassing the performance of the comparative models. This research demonstrates that the method proposed can realize the online monitoring of the temperature of the PIR, which can effectively prevent thermal faults PIR and provide a basis for the opening and closing of the circuit breaker within a short period.
Purification, Molecular Docking and Cytotoxicity Evaluation of Bioactive Pentacyclic Polyhydroxylated Triterpenoids from Salvia urmiensis
Authors: Farimani Mahdi Moridi , Abbas-Mohammadi Mahdi , Ghorbannia-Dellavar Samira , Nejad-Ebrahimi Samad , Hamburger Matthias 
Published: January 2024

AbstractTriterpenoids, as one of the largest classes of naturally occurring secondary metabolites in higher plants, are of interest due to their high structural diversity and wide range of biological activities. In addition to several promising pharmacological activities such as antimicrobial, antiviral, antioxidant, anti-inflammatory and hepatoprotective effects, a large number of triterpenoids have revealed high potential for cancer therapy through their strong cytotoxicity on cancer cell lines and, also, low toxicity in normal cells. So, this study was aimed at discovering novel and potentially bioactive triterpenoids from the Salvia urmiensis species. For this, an ethyl acetate fraction of the acetone extract of the aerial parts of the plant was chromatographed to yield five novel polyhydroxylated triterpenoids (1–5). Their structure was elucidated by extensive spectroscopic methods including 1D (1H, 13C, DEPT-Q) and 2D NMR (COSY, HSQC,
HMBC, NOESY) experiments, as well as HRESIMS analysis. Cytotoxic activity of the purified compounds was also investigated by MTT assay against the MCF-7 cancer cell line. Furthermore, a molecular docking analysis was applied to evaluate the inhibition potential of the ligands against the nuclear factor kappa B (NF-κB) protein, which promotes tumor metastasis or affects gene expression in cancer disease. The 1β,11β,22α-trihydroxy-olean-12-ene-3-one (compound 4) indicated the best activity in both in vitro and in silico assays, with an IC50 value of 32 µM and a docking score value of − 3.976 kcal/mol, respectively.
Antiproliferative and Antitelomerase Effects of Silymarin on Human Colorectal and Hepatocellular Carcinoma Cells
Authors: Rahimi Daruosh , Sharifi Roya , Jaberie Hajar , Naghibalhossaini Fakhraddin 
Published: January 2024

AbstractSilymarin, a widely-used hepatoprotective agent, has shown antitumor properties in both in vitro and animal studies. Currently, there is limited knowledge regarding silymarinʼs antitelomerase effects on human colorectal cancer and hepatocyte carcinoma cells. In this study, we investigated the antiproliferative and antitelomerase effects of silymarin on four human colorectal cancer and HepG2 hepatocyte carcinoma cell lines. The cell viability and telomerase activity were assessed using MTT and the telomerase repeat amplification protocol assay, respectively. We also investigated the effects of silymarin on the expression of human telomerase reverse transcriptase and its promoter methylation in HepG2 cells by real-time RT-PCR and methylation-specific PCR, respectively. Silymarin treatment inhibited cell proliferation and telomerase activity in all cancer cells. After 24 h of treatment, silymarin exhibited IC50 values ranging from 19 – 56.3 µg/mL against these
cancer cells. A 30-min treatment with silymarin at the IC50 concentration effectively inhibited telomerase activity in cell-free extracts of both colorectal cancer and hepatocyte carcinoma cells. Treatment of HepG2 cells with 10 and 30 µg/mL of silymarin for 48 h resulted in a decrease in human telomerase reverse transcriptase expression to 75 and 35% of the level observed in the untreated control (p < 0.01), respectively. Treatment with silymarin (10, 30, and 60 µg/mL) for 48 h did not affect human telomerase reverse transcriptase promoter methylation in HepG2 cells. In conclusion, our findings suggest that silymarin inhibits cancer cell growth by directly inhibiting telomerase activity and downregulating its human telomerase reverse transcriptase catalytic subunit. However, silymarin did not affect human telomerase reverse transcriptase promoter methylation at the concentrations of 10 – 60 µg/mL used in this study.
Affinin, Isolated from Heliopsis longipes, Induces an Antihypertensive Effect That Involves CB1 Cannabinoid Receptors and TRPA1 and TRPV1 Channel Activation
Authors: Luz-Martínez Beatriz A. , Marrero-Morfa Dailenys , Luna-Vázquez Francisco J. , Rojas-Molina Alejandra , Ibarra-Alvarado César 
Published: January 2024

AbstractIn previous studies, we demonstrated that the ethanolic extract of Heliopsis longipes roots and its main alkamide, affinin, elicit a vasorelaxant effect through a mechanism involving activation of the gasotransmitter pathways and stimulation of cannabinoid type 1 receptors and transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 channels. However, it has not yet been demonstrated whether the EEH and affinin are capable of lowering high blood pressure. Therefore, the aim of the present study was to determine the effect of the oral administration of the EEH and affinin on the systolic blood pressure of NG-nitro-L-arginine methyl ester-induced hypertensive rats and to explore the participation of cannabinoid receptors and transient receptor potential channels in the mechanism of action of this alkamide. Our results showed that the ethanolic extract of H. longipes and affinin significantly lowered systolic blood pressure
and induced an improvement in endothelial function, which is associated with increased serum nitric oxide levels. Inhibition of cannabinoid type 1 receptors by rimonabant (3 mg/kg), transient receptor potential ankyrin 1 channels by HC-030031 (8 mg/kg), and transient receptor potential vanilloid 1 channels by capsazepine (5 mg/kg) significantly decreased the antihypertensive effect induced by affinin, suggesting that the blood pressure-lowering effect of this alkamide involves activation of cannabinoid type 1 receptors and transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 channels.
Yield and nutritional quality of intercropped forages for organic production in a hot-summer Mediterranean oak grassland ecosystem
Authors: Plaza Javier , Criado Marco , Morales-Corts M. Remedios , Pérez-Sánchez Rodrigo , Gómez-Sánchez M. Ángeles , Vázquez-de-Aldana Beatriz , Zabalgogeazcoa Iñigo , Palacios Carlos 
Published: January 2024

Context Forage cultivation plays a pivotal role in sustaining ruminants in resource-limited ecosystems such as the hot-summer Mediterranean agroforestry systems of the Iberian Peninsula comprising oak trees (Quercus spp.) and grassland species. Intercropping techniques can enhance forage yields and nutritional quality. Aims This study assessed the yield and nutritional quality of organic forage mixtures in an Iberian oak grassland ecosystem. Methods Six forage associations were assessed over two growing seasons: vetch (Vicia sativa L.)–triticale (Triticum × Secale), vetch–rye (Secale cereale), vetch–oat (Avena sativa), pea (Pisum sativum L.)–triticale, pea–rye, and pea–oat. The data were analysed using a multivariate procedure. Key results Differences in forage composition influenced nutritional quality but not yield. Vetch-based associations exhibited higher crude protein, calcium, phosphorus, potassium, zinc, magnesium, manganese and sulfur contents, along with lower proportions of neutral-detergent fibre and ether extract. The vetch–oat mixture emerged as the highest quality association. Interannual variations in precipitation and temperature caused differences in forage yield, with greater values observed in 2020 than in 2019. Forage associations also had significantly higher nutritional quality in 2020 (increased protein and mineral content, and decreased neutral detergent fibre and lignin). Conclusions All forages demonstrated satisfactory performance and quality, even in the drier conditions of 2019, suggesting high resilience and adaptability to hot-summer Mediterranean oak grassland ecosystems. Implications The findings of this study are relevant for organic farmers in resource-limited ecosystems. This information empowers them to select the most suitable forage species based on the specific agroclimatic conditions of each growing season.
The provision of sexual and reproductive health information and services to travellers: an exploratory survey of Australian travel medicine clinicians
Authors: Warzywoda Sarah , Fowler James A. , Debattista Joe , Mills Deborah J. , Furuya-Kanamori Luis , Durham Jo , Lau Colleen L. , Mullens Amy B. , Istiko Satrio Nindyo , Santaolaya Carlos , Malhotra Juhi , Dean Judith A. 
Published: January 2024

Background International travel can increase the risk of exposure to infectious diseases including sexually transmissible infections (STI). Pre-travel medical consultation provides an opportunity for travel-related health risk assessments and advice. This study explored how travel medicine clinicians integrate sexual and reproductive health (SRH) services into clinical practice. Methods A convenience sample of travel medicine clinicians completed a cross-sectional survey online or via hard-copy disseminated at an annual national Australian travel medicine conference. Results Of the 67 respondents, most (n, 51; 76.1%) had a postgraduate qualification relevant to travel medicine and 55.2% (n, 37) had worked in travel medicine for over 10 years. Only 22.4% (n, 15) reported conducting a SRH history/STI risk assessment for all travel patients. STI testing pre-departure was conducted on patient request (48, 71.6%), if symptomatic (32, 47.8%) or based on risk history (28, 41.8%). SRH information pre-departure was most frequently provided if prompted by patient questions (n, 42; 62.7%), or based on the patient’s history (n, 37; 55.2%). Over half the sample (n, 40; 59.7%) expressed interest in further training in SRH. Conclusion Providing and engaging with additional training may assist travel medicine clinicians to take a more proactive approach to SRH consultations and STI testing. Additional research is needed to explore models of care that will allow comprehensive SRH and STI services to be integrated into standard pre- and post-travel care.
Digital technologies to prevent falls in people living with dementia or mild cognitive impairment: a rapid systematic overview of systematic reviews
Authors: Eost-Telling Charlotte , Yang Yang , Norman Gill , Hall Alex , Hanratty Barbara , Knapp Martin , Robinson Louise , Todd Chris 
Published: January 2024

Abstract

Objective
Falls are a common cause of potentially preventable death, disability and loss of independence with an annual estimated cost of £4.4bn. People living with dementia (PlwD) or mild cognitive impairment (MCI) have an increased fall risk. This overview evaluates evidence for technologies aiming to reduce falls and fall risk for PlwD or MCI.

Methods
In October 2022, we searched five databases for evidence syntheses. We used standard methods to rapidly screen, extract data, assess risk of bias and overlap, and synthesise the evidence for each technology type.

Results
We included seven systematic reviews, incorporating 22 relevant primary studies with 1,412 unique participants. All reviews had critical flaws on AMSTAR-2: constituent primary studies were small, heterogeneous, mostly non-randomised and assessed as low or moderate quality. Technologies assessed were: wearable sensors, environmental sensor-based systems, exergaming, virtual reality systems. We found no evidence relating to apps. Review evidence for the direct impact on falls was available only from environmental sensors, and this was inconclusive. For wearables and virtual reality technologies there was evidence that technologies may differentiate PlwD who fell from those who did not; and for exergaming that balance may be improved.

Conclusions
The evidence for technology to reduce falls and falls risk for PlwD and MCI is methodologically weak, based on small numbers of participants and often indirect. There is a need for higher-quality RCTs to provide robust evidence for effectiveness of fall prevention technologies. Such technologies should be designed with input from users and consideration of the wider implementation context.
Effectiveness of low-density lipoprotein cholesterol reduction with lipid lowering therapy for secondary prevention amongst older individuals: a nationwide cohort study
Authors: Andersson Niklas W , Corn Giulia , Dohlmann Tine L , Melbye Mads , Wohlfahrt Jan , Lund Marie 
Published: January 2024

Abstract

Background
Data about the clinical benefit from initial low-density lipoprotein cholesterol (LDL-C) reduction with lipid lowering treatment for secondary prevention and risk of major vascular events amongst older as compared with younger individuals treated during routine clinical care are limited. We investigated this in a nationwide cohort.

Methods
Individuals aged ≥ 50 years with a first-time hospitalisation for a cardiovascular event (index event, including acute coronary syndrome, non-haemorrhagic stroke, transient ischaemic attack and coronary revascularisation), 1 January 2008 to 31 October 2018, who subsequently used lipid lowering treatment, and had an LDL-C measurement before and after the event were included. Hazard ratios (HRs) for major vascular events per 1 mmol/L reduction in LDL-C were estimated for the included 21,751 older and 22,681 younger individuals (≥/&lt;70 years old) using Cox regression.

Results
LDL-C lowering was associated with a 12% lower risk of major vascular events in older individuals per 1 mmol/L reduction in LDL-C (HR 0.88, 95% confidence interval [CI] 0.84–0.93), with no significant difference compared with the risk reduction amongst younger individuals (HR 0.88, 95% CI 0.83–0.93; P-value for difference between age groups: 0.86). The risk reduction was more pronounced when post hoc restricting, as a proxy for compliance, to new users with an LDL-C reduction above the lowest decile for both older (0.81, 95% CI 0.73–0.90) and younger (0.81, 95% CI 0.72–0.91) individuals.

Conclusions
This study strongly supports a similar relative clinical benefit of LDL-C reduction with lipid lowering treatment for secondary prevention of major vascular events amongst individuals aged ≥70 and &lt;70 years.
Optimal Regulatory Enforcement
Authors: Dari-Mattiacci Giuseppe , Raskolnikov Alex 
Published: January 2024

Abstract
Criminal law applies to everyone, but regulations constrain only those who choose to participate in a regulated activity. Firms considering such participation face three choices: comply with imperfectly enforced rules, violate them, or stay out of the activity altogether. Importantly, regulators not only punish violators but also reward firms with a strong record of compliance. We show that the presence of compliance-contingent rewards in a regime with optional participation unsettles several tenets of the traditional optimal deterrence model: (1) the maximal sanction may not be optimal, (2) it may be optimal to over-deter violations, (3) the probability and magnitude of sanctions may be complements rather than substitutes, (4) more frequent audits may have lower enforcement costs, and (5) the pursuit of a common enforcement objective of raising the rate of compliance may lead to lower welfare even if the overall deterrence level is too low. We illustrate the practical relevance of our findings and conclude that optimal regulatory enforcement is significantly more challenging than the basic deterrence model suggests. (JEL K10, K20, K42)
Advancements in bioinformatics and computational biology: 15th annual Polish Bioinformatic Society Symposium
Authors: Zyla Joanna , Tobiasz Joanna , Mika Justyna , Łabaj Paweł P , Gruca Aleksandra 
Published: January 2024

Abstract
The Polish Bioinformatic Society (PTBI) Symposium convenes annually at leading Polish Universities, and in 2023, the Silesian University of Technology hosted participants from all over the world. The 15th PTBI Symposium, spanning a 3-day duration and divided into four scientific sessions, gathered around 100 participants and centered on research related to machine learning in biomedicine, RNA structure algorithms, next-generation sequencing methods, and microbiome analysis but was not limited to only those topics. The meeting also recognized outstanding research conducted by young scientists by awarding the best poster and best talk. Finally, the awards for the best PhD, MSc, and BSc thesis in bioinformatics defended in Poland were given. This report summarizes the key highlights and outcomes of the meeting.
DIAgui: a Shiny application to process the output from DIA-NN
Authors: Gerault Marc-Antoine , Camoin Luc , Granjeaud Samuel 
Published: January 2024

Abstract

Summary
DIAgui is an R package to simplify the processing of the report file from the DIA-NN software thanks to a Shiny application. It returns the quantification of either the precursors, the peptides, the proteins, or the genes thanks to the MaxLFQ algorithm. In addition, the latest version provides the Top3 and iBAQ quantification and the number of peptides used for the quantification. In the end, DIAgui produces ready-to-interpret files from the results of DIA mass spectrometry analysis and provides visualization and statistical tools that can be used in a user-friendly way.

Availability and implementation
Code and documentation are available on GitHub at https://github.com/marseille-proteomique/DIAgui. The package is written in R and also uses C++ code. A vignette shows its use in an R command line workflow.