bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Angioinvasion Assessment in Papillary Thyroid Cancer Via a Biomarker Panel Involving TAC, 8-OHdG, and Sortilin
Authors: Buczyńska Angelika , Kościuszko Maria , Sidorkiewicz Iwona , Wiatr Aleksandra Anna , Adamska Agnieszka , Siewko Katarzyna , Dzięcioł Janusz , Szelachowska Małgorzata , Krętowski Adam Jacek , Popławska-Kita Anna 
Published: January 2024

Abstract

Context
Papillary thyroid cancer (PTC) aggressiveness and metastatic potential are closely associated with angioinvasion. Identifying angioinvasion accurately is imperative for treatment planning and prognosis.

Objective
This study explores serum biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and oxidative status markers (total oxidative capacity, total antioxidant capacity [TAC], and sortilin), as potential indicators of angioinvasion in PTC.

Design
A cross-sectional study involving 50 angioinvasive patients with PTC (study group) and 30 patients with PTC with low-risk features (reference group). Serum levels of biomarkers were analyzed to determine their association with angioinvasion.

Setting
Patients were recruited from Department of Endocrinology, Diabetology, and Internal Diseases, Medical University of Bialystok, Poland, ensuring representation from a diverse clinical context.

Patients or Other Participants
Participants included patients with PTC, with 50 in the study group and 30 in the reference group. Selection criteria, matching characteristics, and participant completion rates were duly recorded.

Intervention(s)
Serum biomarkers were measured to evaluate their association with PTC angioinvasion.

Main Outcome Measure(s)
Primary outcome measures included serum levels of 8-OHdG, total oxidative capacity, TAC, and sortilin.

Results
Serum levels of 8-OHdG and sortilin were significantly elevated in angioinvasive PTC, whereas TAC showed a notable decrease (all P &lt; .01). A regression panel combining TAC, 8-OHdG, and sortilin demonstrated a high area under the curve value (0.963) for angioinvasion discernment.

Conclusion
Measuring TAC, 8-OHdG, and sortilin levels may serve as potential biomarkers for identifying angioinvasion in PTC. The combined assessment of these biomarkers enhances angioinvasion discernment, aiding risk stratification and personalized treatment decisions. Further validation studies are required before integrating these biomarkers into routine clinical practice. The study adheres to the provided structure, providing concise and supported conclusions based on the results.
The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling
Authors: Highton David , Caldwell Matthew , Tachtsidis Ilias , Elwell Clare E. , Smith Martin , Cooper Chris E. 
Published: January 2024

ABSTRACT
Hypercapnia increases cerebral blood flow. The effects on cerebral metabolism remain incompletely understood although studies show an oxidation of cytochrome c oxidase, Complex IV of the mitochondrial respiratory chain. Systems modelling was combined with previously published non-invasive measurements of cerebral tissue oxygenation, cerebral blood flow, and cytochrome c oxidase redox state to evaluate any metabolic effects of hypercapnia. Cerebral tissue oxygen saturation and cytochrome oxidase redox state were measured with broadband near infrared spectroscopy and cerebral blood flow velocity with transcranial Doppler ultrasound. Data collected during 5-min hypercapnia in awake human volunteers were analysed using a Fick model to determine changes in brain oxygen consumption and a mathematical model of cerebral hemodynamics and metabolism (BrainSignals) to inform on mechanisms. Either a decrease in metabolic substrate supply or an increase in metabolic demand modelled the cytochrome oxidation in hypercapnia. However, only the decrease in substrate supply explained both the enzyme redox state changes and the Fick-calculated drop in brain oxygen consumption. These modelled outputs are consistent with previous reports of CO2 inhibition of mitochondrial succinate dehydrogenase and isocitrate dehydrogenase. Hypercapnia may have physiologically significant effects suppressing oxidative metabolism in humans and perturbing mitochondrial signalling pathways in health and disease.
Empowering tomorrow's leaders: the impact of the 15th Network of Young Researchers in Andrology (NYRA) meeting on male reproductive health and interdisciplinary collaboration
Authors: Marcu Daniel , Egeberg Dorte L. , Richer Guillaume , Houston Brendan , Delgouffe Emily , Saritas Gülizar , Ammar Omar , Wehrli Lydia , Djari Cyril , de la Iglesia Alberto 
Published: January 2024

ABSTRACT
The 15th Network of Young Researchers in Andrology (NYRA) meeting, held at the Palace de Caux, Switzerland, served as a valuable platform to disseminate cutting-edge research and facilitate interactions among early-career researchers and trainees in andrology from around the world. Preceding the 22nd European Testis Workshop, the 2-day event brought together participants from a variety of countries to discuss a range of topics pertaining to men's reproductive health and biology. Specific focuses included piRNAs in mammalian reproduction, biomolecules enhancing sperm physiology, advances in in vitro spermatogenesis, reproductive strategies across species, and career development. A dedicated ‘scientific speed-dating’ social event also stood out, encouraging cross-disciplinary collaborations and strengthening ties within the scientific community. The high participation rate of the meeting highlighted its value in connecting the andrology community. Finally, the announcement of NYRA's merger with the European Academy of Andrology (EAA) marked a pivotal moment, enabling NYRA to support young researchers while collaborating with the EAA to advance andrology research. The 15th NYRA meeting played a crucial role in enhancing knowledge dissemination and andrology research, empowering young researchers, and addressing key challenges in male infertility.
Cadence Modulation during Eccentric Cycling Affects Perception of Effort But Not Neuromuscular Alterations
Authors: MATER ADRIEN , BOLY ADRIEN , MARTIN ALAIN , LEPERS ROMUALD 
Published: January 2024

ABSTRACT

Introduction
A recent study showed that cadence modulation during short eccentric cycling exercise affects oxygen consumption (V̇O2), muscular activity (EMG), and perception of effort (PE). This study examined the effect of cadence on V̇O2, EMG, and PE during prolonged eccentric cycling and exercise-induced neuromuscular alterations.

Methods
Twenty-two participants completed three sessions 2–3 wk apart: 1) determination of the maximal concentric peak power output, familiarization with eccentric cycling at two cadences (30 and 60 rpm at 60% peak power output), and neuromuscular testing procedure; 2) and 3) 30 min of eccentric cycling exercise at a cadence of 30 or 60 rpm. PE, cardiorespiratory parameters, and vastus lateralis and rectus femoris EMG were collected during exercise. The knee extensors’ maximal voluntary contraction torque, the torque evoked by double stimulations at 100 Hz (Dt100) and 10 Hz (Dt10), and the voluntary activation level were evaluated before and after exercise.

Results
V̇O2, EMG, and PE were greater at 30 than 60 rpm (all P < 0.05). Maximal voluntary contraction torque, evoked torque, and Dt10/Dt100 ratio decreased (all P < 0.01) without cadence effect (all P > 0.28). Voluntary activation level remained constant after both eccentric cycling exercises (P = 0.87).

Conclusions
When performed at the same power output, eccentric cycling exercise at 30 rpm elicited a greater PE, EMG, and cardiorespiratory demands than pedaling at 60 rpm. Exercise-induced fatigability was similar in both eccentric cycling conditions without neural impairments, suggesting that eccentric cycling seemed to alter more specifically muscular function, such as the excitation–contraction coupling process. In a rehabilitation context, eccentric cycling at 60 rpm seems more appropriate because it will induce lower PE for similar strength loss compared with 30 rpm.
Febrile seizure management and effectiveness of prevention with antipyretics
Authors: Dra'gon Victoria L , Jadzinski Patryk 
Published: January 2024

Background: Before reaching the age of 5, 2–5% of children will have had a febrile seizure. Most are categorised as simple but they can be complex and carry the risk of complications. They can be frightening for parents. UK guidelines advise against the use of antipyretic drugs to prevent febrile seizure recurrence while being mindful of parental sensitivities. Aim: This systematised literature review aimed to appraise the global body of evidence in relation to current guidelines on using conventional antipyretics for the prevention of febrile seizures and explore factors that influence their management. Method: A research question was developed using the PICO (population/participant(s); intervention(s); comparison/control; outcome) framework and two databases were searched for primary research, and abstracts were screened for relevance. Results: Thirty-four articles were identified, or which three were relevant to the research aim. These were critically appraised using the Mixed Methods Appraisal Tool and five themes were identified. Conclusion: One study found that paracetamol may prevent recurrent febrile seizures, one found a small reduction in febrile seizure recurrence when treated with an antipyretic and one found antipyretics ineffective at reducing febrile seizure recurrence. Similar contemporary studies conducted in the UK population may help to improve understanding of the factors influencing febrile seizure management and the effectiveness of antipyretics.
Variation in patient gender and sexual identity recording within ambulance records
Authors: Groom Nicholas 
Published: January 2024

Background: Health inequality among lesbian, gay, bisexual and transgender people has been highlighted in several reports. Ambulance services have been advised to record the gender identity and sexuality of all patients treated to support monitoring of health equity. Method: Four NHS ambulance services in England were asked for their data showing whether the completed patient record for each incident included gender identity and sexuality. Results: All services responded; data from three were used in the analysis. Only one service had the means to record a patient's sexual orientation. Gender identity was recorded by all services but the rate of data capture as well as potential responses varied between organisations. Discussion: There was little consistency between the three services regarding rates of data being captured, responses and potential answers. These variations could not be explained, although introduction of electronic patient records may impact data capture and quality.
The PJI-TNM classification for periprosthetic joint infections
Authors: Baertl Susanne , Rupp Markus , Kerschbaum Maximilian , Morgenstern Mario , Baumann Florian , Pfeifer Christian , Worlicek Michael , Popp Daniel , Amanatullah Derek F. , Alt Volker 
Published: January 2024

AimsThis study aimed to evaluate the clinical application of the PJI-TNM classification for periprosthetic joint infection (PJI) by determining intraobserver and interobserver reliability. To facilitate its use in clinical practice, an educational app was subsequently developed and evaluated.MethodsA total of ten orthopaedic surgeons classified 20 cases of PJI based on the PJI-TNM classification. Subsequently, the classification was re-evaluated using the PJI-TNM app. Classification accuracy was calculated separately for each subcategory (reinfection, tissue and implant condition, non-human cells, and morbidity of the patient). Fleiss’ kappa and Cohen’s kappa were calculated for interobserver and intraobserver reliability, respectively.ResultsOverall, interobserver and intraobserver agreements were substantial across the 20 classified cases. Analyses for the variable ‘reinfection’ revealed an almost perfect interobserver and intraobserver agreement with a classification accuracy of 94.8%. The category 'tissue and implant conditions' showed moderate interobserver and substantial intraobserver reliability, while the classification accuracy was 70.8%. For 'non-human cells,' accuracy was 81.0% and interobserver agreement was moderate with an almost perfect intraobserver reliability. The classification accuracy of the variable 'morbidity of the patient' reached 73.5% with a moderate interobserver agreement, whereas the intraobserver agreement was substantial. The application of the app yielded comparable results across all subgroups.ConclusionThe PJI-TNM classification system captures the heterogeneity of PJI and can be applied with substantial inter- and intraobserver reliability. The PJI-TNM educational app aims to facilitate application in clinical practice. A major limitation was the correct assessment of the implant situation. To eliminate this, a re-evaluation according to intraoperative findings is strongly recommended.Cite this article: Bone Joint Res 2024;13(1):19–27.
Evaluation of Groundwater Chemistry and Multivariate Statistical Studies in Parts of Tirupur District, India
Authors: S. Vikashini  , K. Raja  , R. Malathy  , S. Anandaraj  
Published: January 2024

Groundwater quality at any location depends on the mutual possessions of several progressions beside the subsurface flow path. The natural history and degree of infectivity in a particular region can be ascertained by hydro-chemical statistics. In order to assess the groundwater chemistry and its appropriateness for consumption purposes, sixty-three subsurface water samples were analyzed. Based on the perceptive of the hydro-geological and groundwater environment, the chemical characteristics of the groundwater were evaluated. The favored parameters for the quality assessment were major anions and cations along with pH, turbidity, total dissolved solids, total hardness, fluoride and iron as trace metals. Total dissolved solids distribution, hydro-chemical facies, Piper diagram, factor analysis, correlation studies and cluster analysis were done to monitor the study zone. The total dissolved solids (TDS) were clustered independently. It was concluded from the assessment that the groundwater of the Tirupur region was critically deteriorated by different anthropogenic activities.
Testing the feasibility, acceptability, and exploring trends on efficacy of the problem management plus for moms: Protocol of a pilot randomized control trial
Authors: Falgas-Bague Irene , Melero-Dominguez Maria , de Vernisy-Romero Daniela , Tembo Thandiwe , Chembe Mpela , Lubozha Theresa , Paul Ravi , Parkerson Doug , Rockers Peter C. , Sikazwe Dorothy , Fink Günther 
Published: January 2024

Mental health disorders are one of the most common causes that limit the ability of mothers to care for themselves and for their children. Recent data suggest high rates of distress among women in charge of young children in Zambia. Nevertheless, Zambia’s public healthcare offers very limited treatment for common mental health distress. To address this treatment gap, this study aims to test the feasibility, acceptability, and potential efficacy of a context-adapted psychosocial intervention. A total of 265 mothers with mental health needs (defined as SRQ-20 scores above 7) were randomly assigned with equal probability to the intervention or control group. The intervention group will receive a locally adapted version of the Problem-Management Plus and “Thinking Healthy” interventions developed by the World Health Organization (WHO), combined with specific parts of the Strong Minds-Strong Communities intervention. Trained and closely supervised wellbeing-community health workers will provide the psychosocial intervention. Mental health distress and attendance to the intervention will be assessed at enrollment and 6 months after the intervention. We will estimate the impact of the intervention on mental health distress using an intention-to-treat approach. We previously found that there is a large necessity for interventions that aim to address mother anxiety/depression problems. In this study, we tested the feasibility and efficacy of an innovative intervention, demonstrating that implementing these mental health treatments in low-income settings, such as Zambia, is viable with an adequate support system. If successful, larger studies will be needed to test the effectiveness of the intervention with increased precision.
Trial registration: This study is registered at clinicaltrials.gov as NCT05627206.
The clinical effectiveness of one-dose vaccination with an HPV vaccine: A meta-analysis of 902,368 vaccinated women
Authors: Setiawan Didik , Nurulita Nunuk Aries , Khoirunnisa Sudewi Mukaromah , Postma Maarten J. 
Published: January 2024

Background
The comprehensive effectiveness of the HPV vaccine has been widely acknowledged. However, challenges such as dosing adherence and limited budgets have led to delays in HPV vaccination implementation in many countries. A potential solution to these issues could lie in a one-dose vaccination with an HPV vaccine, as indicated by promising outcomes in multiple studies.

Methods
In this systematic review and meta-analysis, we examine the comparative effectiveness of the one-dose vaccination with an HPV vaccine against two- and three-dose regimens. Our investigation focuses on clinical efficacy, encompassing the prevention of HPV16, HPV18, and hrHPV infections, HSIL or ASC-H incidence, and CIN2/3 incidence.

Results
Our analysis suggests that a single-dose HPV vaccine may offer effectiveness on par with two- or three-dose schedules. This conclusion is drawn from its capacity to confer immunogenic protection for at least 8 years of follow-up, coupled with its ability to mitigate infections and pre-cancerous occurrences.

Conclusion
While our findings underscore the potential of the one-dose vaccination with an HPV vaccine, further research and prolonged study durations are necessary to establish robust evidence supporting this recommendation. As such, continued investigation will be critical for informing vaccination strategies
Propofol-based total intravenous anesthesia is associated with less postoperative recurrence than desflurane anesthesia in thyroid cancer surgery
Authors: Chiu Wei-Chieh , Wu Zhi-Fu , Lee Meei-Shyuan , Chen Jamie Yu-Hsuan , Huang Yi-Hsuan , Tseng Wei-Cheng , Lai Hou-Chuan 
Published: January 2024

Background
The effects of anesthesia in patients undergoing thyroid cancer surgery are still not known. We investigated the relationship between the type of anesthesia and patient outcomes following elective thyroid cancer surgery.

Methods
This was a retrospective cohort study of patients who underwent elective surgical resection for papillary thyroid carcinoma between January 2009 and December 2019. Patients were grouped according to the type of anesthesia they received, desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival/recurrence curves were presented from the date of surgery to death/recurrence. Univariable and multivariable Cox regression models were used to compare hazard ratios for recurrence after propensity matching.

Results
A total of 621 patients (22 deaths, 3.5%) under desflurane anesthesia and 588 patients (32 deaths, 5.4%) under propofol anesthesia were included. Five hundred and eighty-eight patients remained in each group after propensity matching. Propofol anesthesia was not associated with better survival compared to desflurane anesthesia in the matched analysis (P = 0.086). However, propofol anesthesia was associated with less recurrence (hazard ratio, 0.38; 95% confidence interval, 0.25–0.56; P < 0.001) in the matched analysis.

Conclusions
Propofol anesthesia was associated with less recurrence, but not mortality, following surgery for papillary thyroid carcinoma than desflurane anesthesia. Further prospective investigation is needed to examine the influence of propofol anesthesia on patient outcomes following thyroid cancer surgery.
Using machine learning to assess the extent of busy ambulances and its impact on ambulance response times: A retrospective observational study
Authors: Næss Lars Eide , Krüger Andreas Jørstad , Uleberg Oddvar , Haugland Helge , Dale Jostein , Wattø Jon-Ola , Nilsen Sara Marie , Asheim Andreas 
Published: January 2024

Background
Ambulance response times are considered important. Busy ambulances are common, but little is known about their effect on response times.

Objective
To assess the extent of busy ambulances in Central Norway and their impact on ambulance response times.

Design
This was a retrospective observational study. We used machine learning on data from nearby incidents to assess the probability of up to five different ambulances being candidates to respond to a medical emergency incident. For each incident, the probability of a busy ambulance was estimated by summing the probabilities of candidate ambulances being busy at the time of the incident. The difference in response time that may be attributable to busy ambulances was estimated by comparing groups of nearby incidents with different estimated busy probabilities.

Setting
Medical emergency incidents with ambulance response in Central Norway from 2013 to 2022.

Main outcome measures
Prevalence of busy ambulances and differences in response times associated with busy ambulances.

Results
The estimated probability of busy ambulances for all 216,787 acute incidents with ambulance response was 26.7% (95% confidence interval (CI) 26.6 to 26.9). Comparing nearby incidents, each 10-percentage point increase in the probability of a busy ambulance was associated with a delay of 0.60 minutes (95% CI 0.58 to 0.62). For incidents in rural and urban areas, the probability of a busy ambulance was 21.6% (95% CI 21.5 to 21.8) and 35.0% (95% CI 34.8 to 35.2), respectively. The delay associated with a 10-percentage point increase in busy probability was 0.81 minutes (95% CI 0.78 to 0.84) and 0.30 minutes (95% CI 0.28 to 0.32), respectively.

Conclusion
Ambulances were often busy, which was associated with delayed ambulance response times. In rural areas, the probability of busy ambulances was lower, although the potentially longer delays when ambulances were busy made these areas more vulnerable.
Optimization and kinetics study for the conversion of furfuryl alcohol towards ethyl levulinate using sulfonic acid functionalized catalyst
Authors: Prajapati Rahul V. , Srivastava Sanjay , Jadeja Girirajsinh C. , Parikh Jigisha 
Published: January 2024

Abstract
In the present work, furfuryl alcohol (FAL) alcoholysis towards ethyl levulinate (EL) was studied over a mesoporous SO3H-SBA-15 catalyst. The effect of various operating parameters i.e., temperature, catalyst dose, furfuryl alcohol amount, and time was studied and optimized via robust Response Surface Methodology through central composite rotatable designs (CCRD) method on the conversion of FAL to EL. According to Response Surface Methodology, under optimum reaction conditions viz. temperature 110 °C, catalyst dose 0.42 g, time 3 h, and FAL amount of 1.46 g, maximum EL yield (95 %) was recorded. Further, the effect of reaction parameters on the kinetics of the said reaction was also examined, suggesting the second-order kinetic concerning all operating parameters. Eventually, the reusability of the catalyst is evident in a decrease of almost 40 % yield towards EL in the fourth cycle.