bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological profile of infections caused by Helicobacter pylori diagnosed through histopathological examinations conducted at a reference University Hospital
Authors: Azevedo Ferreira Davi , Moura Ponce de Leon Carlos Márcio , Santos Carmo Egberto 
Published: January 2025

Introduction: This study analyzed cases of Helicobacter pylori infection diagnosed through histopathological examinations. Aim: to analyze the results of anatomopathological examinations of gastric mucosa performed in the Pathology Department. Methods: It was an epidemiological, retrospective, descriptive and analytical study with a quantitative approach. The sample consisted of all the histopathological examinations of gastric mucosa obtained by upper digestive endoscopy (UDE) carried out at the Alcides Carneiro University Hospital between 01/01/2017 and 31/12/2019, for which there was a suspicion of H. pylori infection. Results: A total of 2028 reports and their respective requests were analyzed. The year with the highest prevalence of reports was 2018, with 798 (39.3%) tests carried out. The female sex prevailed with 1313 (64.7%) analyzes. The highest concentration of individuals was between 40 and 59 years of age, with 784 (38.7%). The main endoscopic finding presented by the doctor was gastritis, with 801 cases (39.5%). However, positive results proving clinical suspicion of H. pylori represented a smaller proportion of the findings, with 686 (33.7%). In addition, positive cases for H. pylori were more associated with the 20-59 age group (n=471; 23.2%) and it was found that patients with an endoscopic diagnosis of ulcers were more associated with positive results proving clinical suspicion for H. pylori on pathology examination (n=106; 5.2%). Conclusion: We conclude that one third of the population seen at the hospital for EDA with biopsy and who had clinical suspicion of H. pylori infection were positive for the bacterium in the anatomopathological study subsequently carried out at the hospital during the period studied, corroborating the bacterial association with inflammatory processes of the gastric mucosa already described in previous studies.
SUICIDIOS EN TIEMPOS DE COVID-19 ADOLESCENTES EN CIUDAD REYNOSA TAMAULIPAS
Authors: Zuñiga Avalos Vanessa Guadalupe 
Published: January 2025

En el presente estudio se investigara los factores que influyen para desencadenar el suicidio en adolescentes, se entiende que por adolecentes se tipificara como mayores de 16 y menores de 18 años, basándonos en el artículo 271 del código penal en el estado de Tamaulipas. La pandemia covid-19 es un factor detonante y forma parte del núcleo de la causa. Se van a relacionar algunas conductas de intento de suicidio y suicidio en menores de edad con los autores más destacados y mayor relacionado con este tema para hacer las comparaciones, uno de los autores que tipifica los tipos de suicidio es Emile Durkheim quien categoriza los suicidios como: suicidio egoístas, suicidio anomico, suicidio altruista y suicidio fatalista. Los términos generales en este tema son la vulnerabilidad, violencia familiar y situaciones emocionales.
El objetivo de este estudio es conocer por medio de páginas oficiales y encuestas particulares, los intentos y los suicidios consumados, así mismo relacionarlos con las categorías de algunos autores que hablan sobre el suicidio, relacionarlo con los adolescentes para verificar en el estado de Tamaulipas cual se prolongó más.
EL DERECHO A DECIDIR. ¿POR QUÉ COSTA RICA DEBE DE DESPENALIZAR EL ABORTO EN CASOS DE CONCEPCIÓN DE UN PRODUCTO ANENCEFÁLICO?
Authors: Pereira Rodríguez María Lisa 
Published: January 2025

La interrogante del ¿Por qué Costa Rica debe de despenalizar el aborto en casos de concepción de un producto anencefálico? contiene una serie de respuestas que a través de este instrumento se analizarán con mucho compromiso. Este país ha mostrado a través del tiempo renuencia en la despenalización del aborto en casos como el que nos ocupa, y de esta forma, es como se atropella de forma manifiesta el derecho que ostentan las mujeres de poseer una vida digna, la cual solamente se asegura garantizando el derecho a la salud desde su enfoque más amplio y a su vez, la libertad de decidir sobre su propia corporeidad. Los serios obstáculos que se presentan para que una mujer pueda, si así lo decide, abortar en caso de que el producto una vez fuera del claustro materno, no tenga ninguna esperanza de vida, como lo es la anomalía mortal en mención, deviene en trato cruel e inhumano o peor aún en una forma más de tortura. Un estudio consciente y además técnico de temas como la anencefalia en el producto de la concepción, hará que se caiga en cuenta en las rémoras legales que como país se ha venido incurriendo, afectando así el derecho a decidir de las mujeres y todos los flancos que se transgreden al exigirles mantener un producto, dentro de su cuerpo, que nacerá, pero inmediatamente morirá, obligándoles a seguir un proceso despiadado, vil e inaceptable como lo es conservar por un tiempo indeterminado una formación intrauterina que una vez expulsada dispone de nulo porcentaje de vida. Se concluye en este artículo con la necesidad de incluir dentro de nuestra normativa penal un apartado que permita a las mujeres, que así lo consientan, el aborto en ocasión de la anencefalia en el producto de la concepción y consecuentemente que el Estado brinde los insumos necesarios a nivel de sistema de salud para los procedimientos obstétricos o médicos en general que se requieran, de forma segura y gratuita.
EL CONTROL DE LA CASACIÓN SOBRE LA MOTIVACIÓN DEL FALLO
Authors: Zamora Acevedo Miguel 
Published: January 2025

La investigación analiza la problemática relativa a la impugnación penal adoptada en la fase de admisibilidad del recurso de casación penal, específicamente sobre la inobservancia o aplicación errónea de un precepto legal, sustantivo o procesal. Ello, en razón de posibles errores en la valoración de la prueba y determinación de la premisa fáctica.
Como primer problema se aborda la dicotomía entre el principio de inmediación y la necesidad de revisión del fallo, señalando la inexistencia de contradicción en el análisis de las inferencias probatorias conforme a las reglas procesales vigentes. De seguido, y como segundo punto, se estudia la relación entre los hechos y el derecho, señalando el vínculo necesario, el cual se ve afectado, por el diseño de las reglas de admisión del recurso.
A partir de lo anterior, haciendo una reconstrucción del razonamiento probatorio empleado, se muestra que la revisión en casación de las cuestiones relacionadas con el binomio hechos-derecho es una exigencia que surge de la necesidad de revisión del fallo, así como el resguardo al derecho de la prueba.
A case of long-term use of denosumab for giant cell tumor of bone
Authors: Vladimirova L. Yu. , Abramova N. A. , Vashchenko L. N. , Barashev A. A. , Tikhanovskaya N. M. 
Published: January 2025

Giant cell tumor of bone is a locally aggressive primary bone neoplasm affecting patients aged 20–50 years. Neoplastic stromal cells have a phenotype of immature osteoblasts synthesizing various cytokines and molecular factors leading to excessive activation of osteoclastogenesis and increased osteolysis in giant cell tumor of bone. Long-term treatment with denosumab is recommended for unresectable or disseminated disease.A clinical case of long-term treatment with denosumab of initially generalized giant cell tumor of the right ischial bone with metastases to the lungs is presented. Stabilization of the process was first recorded 3 months after the start of therapy and has been maintained to date. The patient was transferred to a maintenance regimen 3 years after the start of treatment. The treatment was not accompanied by adverse events characteristic of bone-modifying agents.Long-term use of denosumab allowed effective control of the tumor process and maintenance of satisfactory quality of life of the patient. Maintenance regimen of denosumab administration was not accompanied by a decrease in treatment effectiveness.
Fibular-Sided Avulsion of Posterior Inferior Tibiofibular Ligament—Patel-Sharma Fragment
Authors: Patel Sandeep , Dhillon Mandeep S. , Dadra Ankit , Gupta Ansh , Sharma Siddhartha 
Published: January 2025

Case:
A 30-year-old man presented with left proximal tibia fracture (open Grade 3A) and a transverse lateral malleolus fracture (Weber B) following direct impact injury. Computed tomography revealed a rare posteromedial tubercle fibula fracture at the posterior inferior tibiofibular ligament (PITFL) insertion, with syndesmosis disruption. Initial damage control included an external fixator. Definitive surgery, performed 10 days later, used Herbert screws and a tubular plate, along with syndesmotic screws.

Conclusion:
This case highlights a unique fracture pattern: PITFL avulsion from the fibular end which we wish to name as Patel-Sharma fragment. Identifying this fragment is essential as it needs to be fixed to ensure posterior syndesmosis ring stability.
Closed Reduction and Intrafocal Pinning for Complex Dorsal Fracture Dislocation of the Distal Interphalangeal Joint
Authors: Jerome J. Terrence Jose 
Published: January 2025

Case:
Dorsal dislocations of the distal interphalangeal joint with associated volar base fractures of the distal phalanx are complex injuries that pose challenges for achieving stable reduction and restoring optimal joint function. This case report describes the successful management of a 40-year-old male cardiologist who sustained such an injury after a cricket ball trauma. The treatment involved a combined approach of closed reduction, dorsal extension block pinning, and intrafocal pinning of the volar base fracture.

Conclusion:
This combined technique achieved excellent radiological and functional outcomes at 1-year follow-up. The patient regained full range of motion and returned to his preinjury activities without limitations.
Subcellular Systems Follow Onsager Reciprocity
Authors: Horowitz Arie 
Published: January 2025

Abstract

The complexity of prokaryotic and, exceedingly, of eukaryotic cells, challenges the implemen-tation of methodologies to quantify intracellular dynamics. Although stochastic thermodynam-ics can be used to effectively quantify the energetics of single proteins or complexes, there is no statistical approach to determine the macrostate of a whole cell from its subcellular mi-crostates. The objective of this study is to test if Onsager reciprocity, a coupling between ther-modynamic flows, can be established between time-dependent intracellular processes from their measurements in previous studies. A prototypical thermodynamic profile of the cell is for-mulated as a model system to enable representation of its sub systems as force-driven ther-modynamic flows. Onsager reciprocity is validated on the bacterial flagellum and ATP syn-thase. It is then tested on the putative coupling between the contractile ring and treadmilling of the cytoskeleton in bacterial binary fission and eukaryotic cytokinesis, with opposite out-comes. All thermodynamic flows and forces are formulated to comply with their canonical defi-nitions.
Apple fruitlet drop prediction using spectral Vis/NIR and growth diameter times-series
Authors: Biegert Konni , Modugno Stefano , Föll Silas , Peterlin Magdalena , Pichler Daniel , Andergassen Christian , McCormick Roy 
Published: January 2025

Abstract

In apple production different thinning strategies are applied to produce optimal yields of marketable fruit and to reduce the risk of alternate bearing. However, the effectiveness of a chemical thinning treatment is highly variable being influ- enced by the tree’s physiological state and environmental conditions both before and after application. Optical sensing with a visible/near-infrared spectropho- tometer is tested as a prediction tool to decide if a further thinning treatment is required and precisely thin trees in the orchards. In 2023, in Southwest Ger- many and in Northern Italy, the apple cultivars ‘Gala’ and ‘Braeburn’ were thinned between the 8-15 mm fruit diameter growth stage. King and second lateral fruitlets, which were the target of the thinning, were measured with dig- ital calipers and scanned before and up to 13 days after thinning treatments. Thinning treatments effectively reduced fruit set by one half. Receiver operating characteristic curves were tested separately on spectral indices and fruit diame- ter growth. Spectral monitoring recorded similar information as measuring fruit diameter growth. The obtained area under the curve was >75% on 5-8 days after treatment for both cultivars. Persisting fruitlets showed higher light absorption in the chlorophyll and water related wavelength regions and higher light reflectance from the near-infrared region (699 to 939 nm).
One-fifth of the world's population at high risk from climate-related hazards
Authors: Hill Ruth , Gorgulu Nisan , Brunckhorst Ben , Nguyen Minh , Hallegatte Stephane , Naikal Esther 
Published: January 2025

Abstract

Climate change is increasing the frequency and intensity of extreme weather events. When these events occur, they threaten lives and livelihoods. Here we estimate the global population at high risk from climate-related hazards by examining household level vulnerability and local exposure to four types of events: agricultural droughts in rural areas, floods, heatwaves, and cyclones. Under current climate conditions, 4.5 billion people are expected to experience these hazards at intensities exceeding critical thresholds within their lifetime. One third of this population is considered highly vulnerable, based on seven dimensions that influence potential welfare impacts: income, education, access to finance, social protection, drinking water, electricity, and access to services and markets. Overall, we estimate that 1 in 5 people globally are at high risk from these hazards meaning that they are likely to experience them and would struggle to recover from their impacts. While the proportion of the population at high risk has nearly halved since 2010 due to decreased vulnerability, the number of people exposed has increased, and progress has been uneven across regions. This study offers a new global population headcount indicator based on household survey and high-resolution spatial data that will be used to track climate risks across countries and over time.
Usability testing a digital web application for evidence-based commissioning decisions in the context of implementing Mobile Stroke Units in England
Authors: Moseley Lisa , Laws Anna , Allen Michael , Ford Gary A , James Martin , McCarthy Stephen , McClelland Graham , Park Laura J , Pearn Kerry , Phillips Daniel , Price Christopher , Shaw Lisa , White Phil , Wilson Dave , McMeekin Peter , Scott Jason 
Published: January 2025

Abstract

Commissioning of innovations in healthcare is a complex socio-technical process, ideally informed by high quality evidence. However, evidence is not always prepared and presented in a format usable for commissioning decisions. Agile methodology, combined with qualitative co-design, were used to develop a digital web application incorporating machine learning models of stroke outcomes to inform commissioning decisions for the implementation of Mobile Stroke Units (MSUs) in England, followed by usability testing using Think Aloud methodology. Sixteen stakeholders involved in developing consensus on model parameters and pathways participated with data thematically analysed. Required improvements to the web application were identified and novel insights into the complexity of context-specific commissioning decisions were generated, which also informed participants’ views on the viability of MSUs. This study provides empirical evidence in support of developing innovative and accessible digital dissemination methods to engage with commissioning processes and prospectively understand commissioning challenges.
Long-Read Sequencing is Required for Precision Diagnosis of Incontinentia Pigmenti
Authors: Wojcik Monica , Clark Robin , Elias Abdallah , Genetti Casie , Madden Jill , Simpson Dana , Golkar Linda , Zalusky Miranda , Miller Angela , Rodriguez Araceli , Goffena Joy , Dash Camille , Damaraju Nikhita , Gibson Sophia , Storz Sophie , Anderson Zachary , Gustafson Jonas , Thiffault Isabelle , Farrow Emily , Pastinen Tomi , Lin Jasmine , Huang Jennifer , Beggs Alan , Agrawal Pankaj , diseases GREGoR Genomics Research to Elucidate the Genetics of Rare , Miller David , Miller Danny 
Published: January 2025

Abstract

Incontinentia pigmenti (IP) is caused by loss-of-function variants in IKBKG, with molecular genetic diagnosis complicated by a pseudogene. We describe seven individuals from three families with IP but negative clinical testing in whom long-read sequencing identified causal variants. Concurrent methylation analysis explained disease severity in one individual who died from neurologic complications, identified a mosaic variant in an individual with an atypical presentation, and confirmed skewed X-chromosome inactivation in an XXY individual.
Transmission dynamics of Escherichia coli sequence type 131 in households – a “One Health” prospective cohort study
Authors: Mo Yin , Perez Rebecca , The Hao Chung , Vignesvaran Kithalakshmi , Tan Wei Cong , Hui Melissa Chua Sin , Tan En Ying , Peng Si Yu , Zhou Lingyue , Singh Shweta (R) , Yeung Wesley , Seah Ivan , Teo Jeanette , Aung Kyaw Thu , Tang Cheng Yee , Ong Rick , Cooper Ben , Tambyah Paul 
Published: January 2025

Abstract

Escherichia coli sequence type 131 (ST131) is a major cause of community-onset, multidrug-resistant extraintestinal infections. The transmission and carriage dynamics associated with E. coli ST131’s global prevalence remain poorly understood. We collected up to twelve sequential stool samples from 135 human participants and six companion animals and environmental swabs from 34 households, sequencing up to twelve isolates per sample. Each household included an index patient with prior extraintestinal E. coli infection (17 with ST131, 17 with other sequence types) and their coresidents. While most participants carried E. coli ST131 intermittently, we identified a subset of participants that persistently carried E. coli ST131 in high densities (57·79% of E. coli isolates per sample) for a median carriage duration of 86·35 days (80% credible interval (CrI) 30·03 to 188·80). Coresiding with a persistent carrier was associated with an almost-doubled risk of acquiring E. coli ST131 (3·13% daily risk (80% CrI 1·22 to 10·14) versus 1·57% (80% CrI 0·65 to 5·19)). Persistent carriers and their coresidents carried genetically similar ST131 isolates (median single nucleotide polymorphism distance 2, interquartile range 2 to 7), but persistent carriers harboured greater diversity, suggesting that they were the source of inter-individual transmissions. Our results demonstrate that asymptomatic, persistent carriers represent potential reservoirs sustaining community E. coli ST131 transmissions. In identifying this subgroup, we highlight a potential target for public health interventions such as vaccination to limit the spread of multidrug resistance.
Silver Price Trends and its Impact on the Indian Economy Before and After Covid-19
Authors: Bhattacharya Hemant , Roy Rohit 
Published: January 2025

Abstract

This study investigates the relationship between silver price trends and the Indian economy, particularly in the context of the COVID-19 pandemic. Before the pandemic, silver prices were influenced by a mix of domestic and global factors, such as investment sentiment, industrial demand, and cultural significance. However, the pandemic brought substantial disruptions to global markets and the Indian economy, causing a sharp drop in silver prices due to reduced industrial activity and investor uncertainty.
As economies began to recover, silver prices rebounded, driven by increased industrial demand, government stimulus measures, and relaxed restrictions. The analysis highlights the dual role of silver as a commodity and an economic indicator, emphasizing its cultural and economic importance in India. Notably, the country’s silver imports and exports during the pandemic underwent significant shifts, with exports surging due to international shortages and high prices, which benefitted the Indian economy.
Survey data collected from 105 respondents revealed varying perceptions of silver’s value, its role as an investment, and its relationship with economic trends. Findings suggest a general expectation of rising silver prices and continued demand, reflecting optimism about economic recovery.
The study underscores the intricate interplay between silver prices and economic factors, including government policies, inflation, and geopolitical tensions. It concludes by emphasizing the importance of understanding these dynamics to predict future trends and formulate strategies to leverage silver’s economic potential in India.
Influences of land use land cover change and topography on selected physicochemical properties of soils developed from sandstone dominated area of Abrha-We-Atsbeha watershed in Northern Ethiopia
Authors: Muruts Ameteyesus Berhe , Haile Mitiku , Teka Daniel , Gebresamuel Girmay , Amare Solomon , Gebrehiwet Aster Arefaine , Kebede Teame Gebrehiwet 
Published: January 2025

Abstract

The study was conducted to investigate the influence of LULCC and topography on selected physicochemical properties and soil quality index (SQI) of soils developed from sandstone-dominated areas in the AWA watershed, Northern Ethiopia. Eight representative soil profile pits were opened; from those, 46 total soil samples were collected and analyzed for physicochemical properties and SQI using descriptive statistics. Plot-level surveys through questionnaires and focus group discussions were used to assess management options of land use and SQI. The study showed that from 1990-2019, cultivated and bare land decreased by 4.34% and 3.8%, whereas settlement, bush, and grazing lands increased by 2.04, 5.44, and 0.66%, respectively. Soil color showed that (5YR ¾), (7.5 YR4/3), and (3.5YR 5/6) were wet at the surfaces and (7.5 YR ¾), (7.5 YR4/3), and (10YR 2.5/n) were wet at the subsurface in pits 1, 2, and 3, respectively. Sand, clay, and moisture content were significantly varied in land use type at P < 0.05, and clay significantly differed on slope gradient at F (2, 19) = 4.39, p < 0.05. Almost all selected chemical properties have no interaction effect of land use type and slope except K+. The study area's soil reference group was divided into the following categories: fluvisols, regosols, arenosols, cambisols, and leptosols. The result of principal component analysis indicated that the overall average SQI was low, i.e., 0.53. Generally, LULCC is more highly influenced than the slope of the selected physicochemical properties and SQI. Using appropriate management of land is good for developing SQI instruments and services.