bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pivotal bridging study of lurbinectedin as second-line therapy in Chinese patients with small cell lung cancer
Authors: Cheng Ying , Wu Chunjiao , Wu Lin , Zhao Jun , Zhao Yanqiu , Chen Lulu , Xin Ying , Zhang Liang , Pan Pinhua , Li Xingya , Li Juan , Dong Xiaorong , Tang Ke , Gao Emei , Yu Fei 
Published: February 2024

AbstractThis single-arm, multi-center clinical trial aimed to evaluate the safety, tolerability, DLT, recommended dose (RD), preliminary efficacy, and pharmacokinetics (PK) characteristics of lurbinectedin, a selective inhibitor of oncogenic transcription, in Chinese patients with advanced solid tumors, including relapsed SCLC. Patients with advanced solid tumors were recruited in the dose-escalation stage and received lurbinectedin in a 3 + 3 design (two cohorts: 2.5 mg/m2 and 3.2 mg/m2, IV, q3wk). The RD was expanded in the following dose-expansion stage, including relapsed SCLC patients after first-line platinum-based chemotherapy. The primary endpoints included safety profile, tolerability, DLT, RD, and preliminary efficacy profile, while the secondary endpoints included PK characteristics. In the dose-escalation stage, ten patients were included, while one patient had DLT in the 3.2 mg/m2 cohort, which was also the RD for the dose-expansion stage. At cutoff (May 31, 2022), 22 SCLC patients were treated in the ongoing dose-expansion stage, and the median follow-up was 8.1 months (range 3.0–11.7). The most common grade ≥ 3 treatment-related adverse events (TRAEs) included neutropenia (77.3%), leukopenia (63.6%), thrombocytopenia (40.9%), anemia (18.2%), and ALT increased (18.2%). The most common severe adverse events (SAEs) included neutropenia (27.3%), leukopenia (22.7%), thrombocytopenia (18.2%), and vomiting (9.1%). No treatment-related deaths occurred. The Independent Review Committee (IRC)-assessed ORR was 45.5% (95% CI 26.9–65.3). Lurbinectedin at the RD (3.2 mg/m2) showed manageable safety and acceptable tolerability in Chinese patients with advanced solid tumors, and demonstrates promising efficacy in Chinese patients with SCLC as second-line therapy.Trial registration: This study was registered with ClinicalTrials.gov NCT04638491, 20/11/2020.
Concomitant training in robotic and laparoscopic liver resections of low-to-intermediate difficulty score: a retrospective analysis of the learning curve
Authors: Bernardi Lorenzo , Balzano Emanuele , Roesel Raffaello , Ghinolfi Davide , Vagelli Filippo , Menconi Giacomo , Petrusic Antonietta , Mongelli Francesco , Majno-Hurst Pietro , De Simone Paolo , Cristaudi Alessandra 
Published: February 2024

AbstractIn the setting of minimally invasive liver surgery (MILS), training in robotic liver resections (RLR) usually follows previous experience in laparoscopic liver resections (LLR). The aim of our study was to assess the learning curve of RLR in case of concomitant training with LLR. We analyzed consecutive RLRs and LLRs by a surgeon trained simultaneously in both techniques (Surg1); while a second surgeon trained only in LLRs was used as control (Surg2). A regression model was used to adjust for confounders and a Cumulative Sum (CUSUM) analysis was carried out to assess the learning phases according to operative time and difficulty of the procedures (IWATE score). Two-hundred-forty-five procedures were identified (RobSurg1, n = 75, LapSurg1, n = 102, LapSurg2, n = 68). Mean IWATE was 4.0, 4.3 and 5.8 (p < 0.001) in each group. The CUSUM analysis of the adjusted operative times estimated the learning phase in 40 cases (RobSurg1), 40 cases (LapSurg1), 48 cases (LapSurg2); for IWATE score it was 38 cases (RobSurg1), 33 cases (LapSurg1), 38 cases (LapSurg2) respectively. Our preliminary experience showed a similar learning curve of 40 cases for low and intermediate difficulty RLR and LLR. Concomitant training in both techniques was safe and may be a practical option for starting a MILS program.
Impact of the COVID-19 pandemic on the services provided by the Peruvian health system: an analysis of people with chronic diseases
Authors: Villarreal-Zegarra David , Bellido-Boza Luciana , Erazo Alfonso , Pariona-Cárdenas Max , Valdivia-Miranda Paul 
Published: February 2024

AbstractDuring the pandemic, many individuals with chronic or infectious diseases other than COVID-19 were unable to receive the care they needed due to the high demand for respiratory care. Our study aims to assess the impact of the COVID-19 pandemic on services provided to people with chronic diseases in Peru from 2016 to 2022. We performed a secondary database analysis of data registered by the comprehensive health insurance (SIS), the intangible solidarity health fund (FISSAL), and private healthcare institutions (EPS), using interrupted time series analysis. Our study identified 21,281,128 individual users who received care. The pooled analysis revealed an average decrease of 1,782,446 in the number of users receiving care in the first month of the pandemic compared with the expected values for that month based on pre-pandemic measurements. In addition, during the pandemic months, there was an average increase of 57,911 in the number of new additional single users who received care per month compared with the previous month. According to the time-series analysis of users receiving care per month based on each chronic disease group, the most significant decreases included people with diabetes without complications and chronic lung disease.
Development of in-house ELISA based on recombinant gag proteins of small ruminant lentiviruses isolated from goats in Thailand
Authors: Mongkonwattanaporn Tatchapon , Lertwatcharasarakul Preeda , Rukkwamsuk Theera 
Published: February 2024

AbstractSmall ruminant lentiviruses (SRLVs), are grouped in Retroviridae family, remain a significant loss in the small ruminant husbandry. As a result of unavailability of vaccine and effective treatment, the diagnosis plays a crucial role for the control of SRLV infection. However, the major challenge of diagnosis of SRLV infection is the genetic and antigenic variability of the viruses that can lead to a failure in serological detection. This study investigated the circulating strains of the viruses in goats in Thailand and an in-house ELISA was developed. The coding sequences for gag protein were optimized, synthesized, and expressed in Escherichia coli for increasing the sensitivity of ELISA test. A total of 365 serum samples were examined against the recombinant protein in an in-house ELISA. The results showed that the recombinant gag achieves 96.67% sensitivity and 93.18% specificity as compared with the commercially available ELISA test kit.
Bounded contribution of human early visual cortex to the topographic anisotropy in spatial extent perception
Authors: Ryu Juhyoung , Lee Sang-Hun 
Published: February 2024

AbstractTo interact successfully with objects, it is crucial to accurately perceive their spatial extent, an enclosed region they occupy in space. Although the topographic representation of space in the early visual cortex (EVC) has been favored as a neural correlate of spatial extent perception, its exact nature and contribution to perception remain unclear. Here, we inspect the topographic representations of human individuals’ EVC and perception in terms of how much their anisotropy is influenced by the orientation (co-axiality) and radial position (radiality) of stimuli. We report that while the anisotropy is influenced by both factors, its direction is primarily determined by radiality in EVC but by co-axiality in perception. Despite this mismatch, the individual differences in both radial and co-axial anisotropy are substantially shared between EVC and perception. Our findings suggest that spatial extent perception builds on EVC’s spatial representation but requires an additional mechanism to transform its topographic bias.
The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection
Authors: Vieira Marta F. M. , Hernandez Guillem , Zhong Qiyun , Arbesú Miguel , Veloso Tiago , Gomes Tiago , Martins Maria L. , Monteiro Hugo , Frazão Carlos , Frankel Gad , Zanzoni Andreas , Cordeiro Tiago N. 
Published: February 2024

AbstractThe translocated intimin receptor (Tir) is an essential type III secretion system (T3SS) effector of attaching and effacing pathogens contributing to the global foodborne disease burden. Tir acts as a cell-surface receptor in host cells, rewiring intracellular processes by targeting multiple host proteins. We investigated the molecular basis for Tir’s binding diversity in signalling, finding that Tir is a disordered protein with host-like binding motifs. Unexpectedly, also are several other T3SS effectors. By an integrative approach, we reveal that Tir dimerises via an antiparallel OB-fold within a highly disordered N-terminal cytosolic domain. Also, it has a long disordered C-terminal cytosolic domain partially structured at host-like motifs that bind lipids. Membrane affinity depends on lipid composition and phosphorylation, highlighting a previously unrecognised host interaction impacting Tir-induced actin polymerisation and cell death. Furthermore, multi-site tyrosine phosphorylation enables Tir to engage host SH2 domains in a multivalent fuzzy complex, consistent with Tir’s scaffolding role and binding promiscuity. Our findings provide insights into the intracellular Tir domains, highlighting the ability of T3SS effectors to exploit host-like protein disorder as a strategy for host evasion.
The climate regime after Paris: an opportunity for regional leadership beyond the State?
Authors: Dias Ana , Antunes Sandrina 
Published: February 2024

AbstractIn the fast-changing landscape of global climate governance, a more polycentric climate regime was recognized with the Paris Agreement. Given the possibility for non-state actors to become agents of change, this paper observes that dynamics of climate leadership are also being defined by regional governments in federal or decentralized systems. Regional governments do so by actively engaging in Paris’ climate efforts by using their self-governing capacities to set their own internal and external climate strategies that may anticipate, bypass, or surpass state action. Although studies have explored leadership dynamics in polycentric structures, the field of climate leadership lacks conceptual and empirical research on regional climate action. Relying on the literature of polycentric governance and climate leadership, our paper (1) articulates the research gap on the phenomenon of regional climate leadership beyond the state and (2) suggests a revised perspective on climate leadership applied to federal or decentralized contexts.
A wheel-shaped Zr-substituted phosphotungstate [{Zr(C2O4)2}3 (PO4)(P6W39O150)]39− with tunable proton conduction properties
Authors: Yang Dongsheng , Liu Lihua , Zhang Yunfan , Zhang Miao , Ma Pengtao , Wang Jingping , Niu Jingyang 
Published: February 2024

A novel wheel-shaped Zr-substituted phosphotungstate, [N(CH3)4]2K16Na10.5H10.5[{Zr(C2O4)2}3(PO4)(P6W39O150)]⋅45H2O was prepared, which exhibited a high proton conductivity of 1.18 × 10−2 S cm−1 at a higher temperature of 368 K.
Applying the Evidence: Taste Manipulation as a Dysphagia Management Strategy
Authors: Westemeyer Ross M. , Dietsch Angela M. , Mulheren Rachel W. 
Published: February 2024

Purpose:
This narrative review aims to summarize the evidence regarding taste manipulation as a dysphagia management strategy within the evidence-based practice framework, with a focus on clinical application for speech-language pathologists.

Method:
First, we present background information on the physiology of taste and swallowing. A summary of research evidence on the effect of taste on swallowing is presented, followed by suggested methods for incorporating taste into swallowing evaluation and intervention. An overview of individual factors that can impact taste perception is provided. Finally, we discuss methods of clinical application and future directions for clinicians.

Conclusions:
Although taste manipulation has received increased attention in the research literature, further research is needed to clarify its interaction with swallowing, particularly given the multisensory nature of eating and individual factors that mediate taste perception. Much of the existing evidence is based on participants without dysphagia; additional clinical research is needed on taste manipulation in persons with dysphagia. Clinicians can incorporate taste in their evaluation of swallowing and treatment, and consider how individual taste perception and preferences impact dysphagia management.
Estudio microbiológico, químico y sensorial de vinos tipo fino obtenidos de solera con 14% v/v de etanol
Authors: Trinidad Alcalá-Jiménez María , Carlos García-García Juan , Muñoz-Castells Raquel , Carbonero-Pacheco Juan , Moreno-García Jaime , García-Martínez Teresa , Peinado Rafael A. , Moreno Juan , Mauricio Juan Carlos 
Published: February 2024

Resumen
Los vinos especiales tipo “Fino” se caracterizan por largos periodos de crianza biológica durante los cuales se desarrolla una bio-película denominada “velo de flor” formada principalmente por cepas de Saccharomyces cerevisiae y otras levaduras no-Saccharomyces. La legislación establece para estos vinos un contenido en etanol del 15- 17 % v/v y sin embargo, el mercado actual demanda vinos con menor contenido. Esta comunicación presenta los resultados de análisis realizados en velos y vinos de barriles de la solera con 14 % v/v en alcohol, seleccionados en una bodega de la DOP Montilla-Moriles y en otra de la DOP Jerez. El estudio microbiológico de vinos de la solera con diferente contenido alcohólico a los 10 meses de crianza no presentó grandes diferencias entre ellos, siendo Torulaspora delbrueckii, la especie aislada con mayor frecuencia entre las no-Saccharomyces. Se observaron cambios en el contenido de ciertos alcoholes superiores, compuestos carbonílicos, ésteres etílicos y polioles en las dos bodegas. La evaluación sensorial realizada por los expertos catadores de ambos Consejos reguladores solo mostró diferencias significativas entre las muestras de vinos con el contenido habitual y los vinos con menor alcohol en la limpidez en los vinos de Jerez y en el carácter frutal en vinos de Montilla-Moriles.
Analyse der Bedeutung des Öko-Weintourismus in Deutschland
Authors: Szolnoki Gergely 
Published: February 2024

Abstract
Nachhaltige Aspekte des Weintourismus gewannen in den letzten Jahren zunehmend an Bedeutung. Die ökologische Nachhaltigkeit von Weingütern in Form der Öko-Zertifizierung ist kein direkter Bestandteil des Weintourismus, kann dennoch eine wichtige Rolle beim Besuch eines Weinguts spielen. Öko-Weintourismus bedeutet, dass zertifizierte Öko-Weingüter weintouristische Aktivitäten anbieten und mit bewusster und gezielter Kommunikation die nachhaltige Seite des Betriebes bewerben. Zertifizierte Weingüter haben dadurch eine große Chance, auch in der Direktvermarktung zu profitieren und Öko-Weintourismus zu etablieren. In einer Studie mit 32 Weingütern aus 10 verschiedenen deutschen Weinbauregionen wurde die touristische Attraktivität, die Bedeutung der Öko-Zertifizierung und die zukünftige Entwicklung des Öko-Weintourismus aus Sicht der Erzeuger untersucht. Die Ergebnisse zeigen, dass es gewisse Anhaltspunkte dafür gibt, die Öko-Zertifizierung als Alleinstellungsmerkmal zu nutzen, aber es scheint, dass die Weingüter diese Möglichkeiten nicht vollständig ausschöpfen. Diese Studie kann den Bioweingütern helfen, ein transparentes Bild der aktuellen Situation in Bezug auf die Relevanz zu erhalten und Kommunikationsbarrieren abzubauen, um mit potenziellen Besuchern des Weinguts in Kontakt zu treten.
Le processus de codification des résolutions de l’OIV : harmonie entre procédé juridique et digitalisation du secteur vitivinicole
Authors: Feuilloley Alexis , Espinoza Alejandro Fuentes , Jacquet Olivier , Juban Yann , Malpel Georges-Pierre , Ruf Jean-Claude 
Published: February 2024

Résumé
L’Organisation Internationale de la Vigne et du Vin (OIV) adopte des résolutions depuis presque un siècle sur des sujets variés pour le secteur vitivinicole. Ce corpus normatif a eu divers impacts, ajoutant une véritable plus-value à l’organisation. Une fois ce cadre posé et cet état des lieux effectué, dans l’optique de développer une meilleure culture d’évaluation des instruments internationaux, un processus de codification est amorcé au sein du Secrétariat. Ce processus s’inscrit dans le cadre du projet de digitalisation lancé par le Plan stratégique de l’OIV ; prouvant que la corrélation entre le processus de codification et la digitalisation est le résultat d’une harmonie parfaite opentre un procédé juridique endurant et les avancées technologiques modernes, qui ont pour finalité d’offrir une accessibilité de plus en plus croissante aux usagers.
Grape stalks: From wastes to source of antioxidants and nutraceuticals
Authors: Antonella Costantini , Silvia Tabasso , Roberto Mazzoli , Paola Ponsetto , Vitale Pietro , Gaudino Emanuela Calcio , Giorgio Grillo , Bertolino Andrea , Christos Tsolakis , Giancarlo Cravotto , Enrica Pessione , Emilia Garcia-Moruno 
Published: February 2024

Wine production is one of the most significant agricultural activities worldwide. The winemaking process generates large amounts of by-products: grape marc, stalks, and exhausted grape marc. Until now, many studies have been focused on marc valorization, very few on stalks. The aim of this research was to deeply explore the potential of residual stalks in the wine industry from a circular economy perspective.
Polyphenols were extracted from stalks with new sustainable technologies in the frame of “green chemistry” without the use of hazardous solvents. Extracts were analyzed for total phenolic compound content (TPC) and their antioxidant activity was determined.
As polyphenols can have antimicrobial activity, the effect of the extracted polyphenols against wine-spoiling yeast Brettanomyces bruxellensis was determined. The percent reduction of the culture optical density, in the presence or absence of polyphenols, was compared to assess the antimicrobial activity of the samples.
The results obtained underline the importance of winemaking by-products (stalks) and their eco-friendly valorization to obtain molecules for food, nutraceutical and cosmetic industries.
Effects of Eccentric Phase Velocity on Bench Press Concentric Bar
Velocity in the Young and Elderly
Authors: Calandrini Antenor , Penna Eduardo Macedo , Monteiro Elren Passos , Boullosa Daniel , Coswig Victor Silveira 
Published: February 2024

AbstractThis study aimed to investigate the impact of bar velocity during the eccentric
phase on subsequent concentric performance in the young and elderly. Twelve
elderly women (65.2+4.2 years) and 16 young women (23.1+2.1
years) were randomly assigned to four experimental conditions that combined
high-velocity eccentric actions (HVECC; maximum velocity) and
moderate-velocity eccentric actions (MVECC; 2.0 s), using
30% and 60% of their 1-repetition maximum (1RM) on the Smith
machine bench press. Measurements of mean propulsive velocity (MPV), peak
velocity (PV), and mean power (MP) were recorded. Two-way ANOVA with repeated
measures was applied for each variable, when needed, the Bonferroni post hoc was
used. Statistical significance was set at p<0.05, and effect size (ES)
was established by Cohen’s d
z. The results
demonstrated that elderly women showed improved performance in MPV
(+10.0%; ES=− 0.58; p=0.009) and
MP (+11.7%; ES=− 0.14; p=0.045)
when utilizing HVECC at 30% 1RM only. Moreover, young women
exhibited superior performance for both 30% and 60% 1RM when
using HVECC for all variables analyzed (p<0.05). The
HVECC appears to have an impact on the subsequent performance of
the concentric phase, particularly when lighter loads (30% 1RM) are
utilized, regardless of the age group.
Tertiary Amines as Temporary Masked Secondary Amines: A Direct Access to 5-Dialkylamino-1,2,4-oxadiazoles from 1,2,4-Oxadiazol-5(4H)-ones
Authors: Phakhodee Wong , Alfliadhi Muh , Pattarawarapan Mookda , Hongsibsong Surat , Wiriya Nittaya 
Published: February 2024

AbstractA novel strategy utilizing tertiary amines as temporary masked secondary amines to synthesize 5-dialkylamino 1,2,4-oxadiazoles via Ph3P-I2 mediated amination of 1,2,4-oxadiazol-5(4H)-ones was developed. A one-step N-dealkylative functionalization of tertiary amines with the 1,2,4-oxadiazole ring enables a convenient access to diverse 5-amino-1,2,4-oxadiazoles. Additionally, orthogonally functionalized piperazine derivatives can be effectively constructed through site-selective reaction of 1,4-dialkylpiperazines or via a sequential N-functionalization of 1-methylpiperazine obviating laborious protection/deprotection steps.
Cytogenetic Alterations and Correlation with Age and Gender in Patients of Multiple Myeloma: A Study from a Tertiary Care Center in Eastern India
Authors: Jha Karuna , Saha Sandeep , Bhattacharyya Maitreyee 
Published: February 2024

Background Multiple myeloma is a cytogenetically heterogeneous, evolving, and incurable disease. Differences in prevalence of myeloma already exist in Indian subcontinent as compared with Western world countries. This study attempts to investigate differences in incidence of cytogenetic abnormalities (CA) in Eastern Indian patients and study differences in incidence with respect to age and gender.
Materials and Methods Interphase fluorescence in situ hybridization (FISH) was applied on purified plasma cells of 280 newly diagnosed myeloma cases using specific probes.
Statistical Analysis Data was analyzed using SPSS software version 25.
Results Note that 51.07% patients were FISH positive. Del13q was the most common CA. Significant association of del 13q with t(4;14), del 17p, and gain of 1q was seen. The frequencies of FISH positive and negative groups differed in the different age groups; higher number of cases in 41 to 50 years group in FISH positive group (p < 0.05) and lower number of cases in FISH positive group in 61 to 70 years (p < 0.05) as compared with FISH negative group. Del 17p had higher number of cases in age group 41 to 50 years and 51 to 60 years as compared with other age groups. Incidence of t(11;14) was in 5th to 7th decade while del 13q and t(4;14) had the widest range of age at presentation. Gender disparities were seen in high-risk cytogenetics like del 17p and 1q gain.
Conclusion The differences in incidence rate of CAs per se in myeloma cases diagnosed in Indian subcontinent and the differences in incidence with respect to age and gender warrant further multicentric studies.
Investigation of the In Vivo Performance of Metal-on-Metal Motec Total Wrist Arthroplasty – An Explant Analysis
Authors: Kandemir Göksu , Julian Harriet S. , Joyce Thomas J. , Brown Daniel J. 
Published: February 2024

Abstract
Background Despite the Motec metal-on-metal (MoM) total wrist arthroplasty (TWA) being among the most implanted and most reported implants, there remains concern about the articulation following the issues in hips, where early wear led to catastrophic failure.
Methods Explant analysis was undertaken on seven MoM Motec wrists, explanted for technical issues in the first 3 years postimplantation, at the macro-, micro-, and nanoscales.
Results Compared with unworn Motec implants, five of the explanted heads and five of the cups became smoother in vivo. The articulating surfaces of every explanted component had negative skewness. The articulating surfaces of the components did not show any of the major damage associated with hip implants but did demonstrate multidirectional scratches and dark marks mainly situated toward their equator. Four explants showed indentation marks on the rims of their cups and necks from component impingement. The nano- and macroscale observations suggested abrasive wear to be the dominant wear mechanism. Most components demonstrated evidence of self-polishing.
Conclusion In the short term, the MoM Motec TWA does not seem to be affected by the wear issues seen in failing MoM total hip replacements with all of the explanted Motec components remaining within manufacturing tolerances