bluuebunny/crossref_metadata_2025_split huggingface dataset:
Track Lab: extensible data acquisition software for fast pixel detectors, online analysis and automation
Authors: Mánek P. , Burian P. , David-Bosne E. , Smolyanskiy P. , Bergmann B. 
Published: January 2024

Abstract
Fast, incremental evolution of physics instrumentation raises the question of efficient software abstraction and transferability of algorithms across similar technologies. This contribution aims to provide an answer by introducing Track Lab, a modern data acquisition program focusing on extensibility and high performance. Shipping with documented API and more than 20 standard modules, Track Lab allows complex analysis pipelines to be constructed from simple, reusable building blocks. Thanks to multi-threaded infrastructure, data can be clustered, filtered, aggregated and plotted concurrently in real-time. In addition, full hardware support for Timepix2, Timepix3 pixel detectors and embedded photomultiplier systems enables such analysis to be carried out online during data acquisition. Repetitive procedures can be automated with support for motorized stages and X-ray tubes. Freely distributed on 7 popular operating systems and 2 CPU architectures, Track Lab is a versatile tool for high energy physics research.
Amrubicin encapsulated PLGA NPs inhibits the PI3K/AKT signaling pathway by activating PTEN and inducing apoptosis in TMZ-resistant Glioma
Authors: Younis Muhammad , Shaikh Sana , Shahzad Khawar Ali , Tan Fei , Wang Zhao , Lashari Mushtaq Hussain 
Published: January 2024

Abstract
Glioblastoma (GBM) remains a challenging malignancy due to its aggressive nature and the lack of efficacious therapeutic interventions. Nanotechnology-based approaches exhibit promise in GBM treatment; however, the successful translation of these strategies from preclinical models to clinical settings is hindered by inefficient nanoparticle clearance from vital organs. Addressing this concern, we investigated the therapeutic potential of amrubicin (AMR) encapsulated within poly (lactic-co-glycolic acid) nanoparticles (AMR-PLGA-NPs) in combating temozolomide (TMZ) resistant GBM. The study demonstrated that AMR-PLGA-NPs exerted a pronounced inhibitory effect on the cellular viability and migratory capacity of TMZ-resistant GBM cells. Furthermore, these nanoparticles exhibited considerable efficacy in downregulating the PI3K/AKT signaling pathway, thereby inducing apoptosis specifically in TMZ-resistant glioma cells and glioma stem-like cells through the activation of PTEN. Notably, in vivo experimentation revealed the ability of AMR-PLGA-NPs to traverse biological barriers within murine models. Collectively, these findings underscore the potential therapeutic utility of AMR-PLGA-NPs as a versatile nanoplatform for addressing the formidable challenges posed by GBM, particularly in mitigating drug resistance mechanisms. The study substantiates the stability and safety profile of AMR-PLGA-NPs, positioning them as a promising avenue for combating drug resistance in GBM therapeutics.
Experimentally ruling out joint reality based on operational completeness
Authors: Zhang Qiuxin , Xiang Yu , Gao Xiaoting , Zhu Chenhao , Wang Yuxin , Ding Liangyu , Zhang Xiang , Zhang Shuaining , Cheng Shuming , Hall Michael J W , He Qiongyi , Zhang Wei 
Published: January 2024

Abstract
Whether the observables of a physical system admit real values is of fundamental importance to a deep understanding of nature. In this work, we report a device-independent experiment to confirm that the joint reality of two observables on a single two-level system is incompatible with the assumption of operational completeness, which is strictly weaker than that of preparation noncontextuality. We implement two observables on a trapped

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ion to test this incompatibility via violation of certain inequalities derived from both linear and nonlinear criteria. Moreover, by introducing a highly controllable dephasing channel, we show that the nonlinear criterion is more robust against noise. Our results push the fundamental limit to delineate the quantum–classical boundary and pave the way for exploring relevant problems in other scenarios.
Use of a forced convection solar dryer for the reduction of post-harvest losses: case of the ‘akikon’ tomato variety in benin (West Africa)
Authors: Vitouley Armel , Hounsokou Christophe G , Kouchadé Clément A , Hounguè Guy Hervé , N’Gobi Gabin Koto , Adounkpè Julien , Kounouhéwa Basile 
Published: January 2024

Abstract
The local variety tomato (Lycopercicum esculentum Mill) named ‘akikon’ is one of the most consumed and widely cultivated fruiting vegetables in Benin Republic. In this work, we designed and built a dryer usable for limiting the frequent losses of the massive produced tomatoes. This paper analyzes the first results, obtained from the different experiments carried out with the developed dryer, in a context of forced convection. The results showed that increasing the temperature from 55 to 70 °C resulted in a shorter drying time decreasing from 1266 to 672 min with a brighter colour of the dried tomatoes for 70 °C. However, the increase of temperature does not affect the smell of the dried tomatoes. After drying, 7 to 8 months were required before we notice a colour change (from red to red-brown) of the dried product , indicating that the storage method still needs to be improved.
Ultrasonic velocity measurements of backscattered acoustic waves for monitoring the enzymatic coagulation of milk
Authors: Jaafari Nidae , Amghar Abdellah , Banouni Hicham , Agounad Said , Bakkali Firdaous 
Published: January 2024

Abstract
In this work, the milk coagulation process was monitored by a nondestructive ultrasonic technique. Three analysis methods were used to calculate ultrasonic wave velocity and assess their effectiveness in tracking the physicochemical changes: Cross-correlation, Spectrum ratio, and Smoothed Pseudo-Wigner-Ville transform. The obtained results show a consistency between the velocity measurements made by these three methods, with a steady increase observed during coagulation and both phases are visible. The time-frequency method was most effective, showing a clearer transition between the two phases. This study suggests that non-destructive ultrasonic techniques with time-frequency analysis could be advantageous for monitoring milk coagulation and ensuring dairy product quality.
Structural, optical and magnetic properties of Cu doped CeO2 nano powders synthesized by solid state reaction
Authors: Subbaiah G Chinna Venkata , Rao N Madhusudhana 
Published: January 2024

Abstract
In this research work, the structural, optical, and magnetic properties of Ce1−xCuxO nanoparticles have been reported. Solid state reaction technique was employed to synthesize the nanoparticle samples. The synthesized materials were analysed structural properties from x-ray diffraction (XRD) observed that the crystallite size increased from16.9 nm to 40.43 nm and the lattice constant increased with increase of Cu doping concentration, and the structural properties after doping confirm the absence of other phase and synthesized samples had a cubic structure. Using SEM and EDAX, the nanoparticles surface morphology and elemental composition in investigated. The nanoparticles have a spherical shape and approximately the expected stoichiometric ratio. The optical band gap of copper doped cerium oxide nanoparticles is calculated and found the band gap decreased with increased dopant concentration. Ce1−xCuxO nanoparticles using photoluminescence (PL) analysis at excitation wavelengths of 350 nm revealed emissions of the violet, blue, green, and red regions within the range of 350–700 nm. Vibrating sample magnetometer was found that the samples were room temperature ferromagnetic in nature and strength of magnetic moment increased with increase of doping concentration.
selscan 2.0: scanning for sweeps in unphased data
Authors: Szpiech Zachary A 
Published: January 2024

Abstract

Summary
Several popular haplotype-based statistics for identifying recent or ongoing positive selection in genomes require knowledge of haplotype phase. Here, we provide an update to selscan which implements a re-definition of these statistics for use in unphased data.

Availability and implementation
Source code and binaries are freely available at https://github.com/szpiech/selscan, implemented in C/C++, and supported on Linux, Windows, and MacOS.
Long amplicon nanopore sequencing of Botrytis cinerea and other fungal species present in infected grapevine leaf samples
Authors: Baramidze Vladimer , Sella Luca , Japaridze Tamar , Abashidze Nino , Lamazoshvili Daviti , Dzotsenidze Nino , Tomashvili Giorgi 
Published: January 2024

Abstract
Botrytis cinerea is a well-known plant pathogen responsible for grey mould disease infecting more than 500 plant species. It is listed as the second most important plant pathogen scientifically and economically. Its impact is particularly severe in grapes since it affects both the yield of grape berries and the quality of wines. While various methods for detecting B. cinerea have been investigated, the application of Oxford Nanopore Technology (ONT) for complete ribosomal operon sequencing, which has proven effective in human and animal fungal research and diagnostics, has not yet been explored in grapevine (Vitis vinifera) disease research. In this study, we sequenced complete ribosomal operons (∼5.5 kb amplicons), which encompass the 18S, ITS1, 5.8S, ITS2, and 28S regions, from both pure cultures of B. cinerea and infected grapevine leaf samples. Minimap2, a sequence alignment tool integrated into the EPI2ME software, served as a taxonomy classifier, utilizing the custom reference database FRODO. The results demonstrate that B. cinerea was detectable when this pathogen was not the dominant fungal species in leaf samples. Additionally, the method facilitates host DNA-free sequencing and might have a good potential to distinguish other pathogenic and non-pathogenic fungal species hosted within grapevine’s infected leaves, such as Alternaria alternata, Saccharomyces cerevisiae, Saccharomyces boulardii, Mucor racemosus, and Ascochyta rabie. The sequences were uploaded to the NCBI database. Long amplicon sequencing method has the capacity to be broadened to other susceptible crops and pathogens, as a valuable tool for early grey rot detection and mycobiome research. Future large-scale studies are needed to overcome challenges, such as comprehensive reference databases for complete fungal ribosomal operons for grape mycobiome studies.
Therapeutic value of lymph node dissection for Siewert type II and III adenocarcinoma: meta-analysis
Authors: Chen Xiao-Dong , Chen Qing-Chuan , Xu Rui , Zhao Fa-Zhi 
Published: January 2024

Abstract

Background
Adenocarcinoma of the oesophagogastric junction presents an increasing incidence. Surgical resection with lymphadenectomy is the only curative treatment modality at the present time, but the optimal extent of lymphadenectomy is debatable. The aim of the present meta-analysis was to estimate the therapeutic value of each nodal station.

Methods
Studies reporting the therapeutic value index of each nodal station in Siewert types II/III oesophagogastric junction (EGJ) were searched in PubMed, Web of Science and Embase up to October 2022. This index was calculated by multiplication of metastatic incidence and 5-year overall survival rate at each nodal station. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Pooled metastatic incidence and therapeutic value index were calculated using RevMan 5.4.

Results
Twelve studies involving 3513 patients were included. Nodes No. 3, 1, 7 and 2 were routinely dissected and achieved a high (≥10) or moderate (5–10) therapeutic value index in decreasing order, due to their high metastatic incidence and favourable survival rate. The index was relatively low (2–5) in suprapancreatic nodes No. 9, 11p and 8a. The index for nodes No. 4d and 10 was relatively low in Siewert type Ⅲ EGJ but very low (&lt;2) in type Ⅱ. The index was very low for nodes No. 5, 6, 11d and 12a, due to their low metastatic incidence and poor survival if positive. Para-aortic, parahiatal and mediastinal nodes were dissected only in highly selected cases. Dissection of the lower mediastinal nodes, especially No. 110, could improve survival rates in type Ⅱ EGJ.

Conclusion
These data could help assess the optimal extent of lymphadenectomy for EGJ. Nodes No. 1, 2, 3, 7, 8a, 9 and 11p need routine dissection in both Siewert types Ⅱ/Ⅲ EGJ; nodes around the lower oesophagus (especially No. 110) in Siewert type Ⅱ EGJ and nodes No. 4d and 10 in Siewert type Ⅲ EGJ might be considered for dissection.
Exercise-induced vasospastic angina diagnosed with a hand grip test in the catheterization laboratory: a case report
Authors: Kawase Yoshiaki , Warisawa Takayuki , Kikuchi Kento , Mizukami Takuya , Matsuo Hitoshi 
Published: January 2024

Abstract

Background
Exercise-induced vasospastic angina (VSA) is a relatively uncommon clinical scenario and is difficult to diagnose in the catheterization laboratory.

Case summary
A 61-year-old Japanese man presented to our hospital with complaints of angina upon exertion in the morning. Neither a 12-lead electrocardiogram nor an echocardiogram showed any abnormal findings. Invasive coronary angiogram revealed moderate stenosis in the left anterior descending coronary artery. A hand grip test was performed, during which the patient experienced chest pain, and coronary angiogram showed coronary spasm at the site of organic stenosis with delayed coronary flow. Intracoronary nitrates (300 ug) were administered, resulting in the release of coronary spasm.

Conclusion
The hand grip test may serve as a useful method for diagnosing exercise-induced VSA in the catheterization laboratory.
Minimally invasive coil embolization for significant left-to-right shunts due to giant coronary-to-pulmonary artery fistulas: a case report
Authors: Namura Sato , Konishi Hiroki , Nishio Ryo , Yamamoto Hiroshi 
Published: January 2024

Abstract

Background
Coronary-to-pulmonary artery fistula (CPF) is a rare disease, and its optimal treatment strategy remains controversial. Herein, we report a rare case of minimally invasive coil embolization of giant CPFs.

Case summary
A 78-year-old man with a history of persistent atrial fibrillation and lumbar canal stenosis presented to our hospital with breathlessness. Cardiac computed tomography revealed giant CPFs inducing a significant left-to-right shunt (Qp/Qs 1/2.1) with a coronary artery aneurysm smaller than the size indicated for surgical treatment. To reduce the left-to-right shunt flow, coil embolization procedures for the fistulas were performed twice. Initially, the fistula arising from the right coronary artery was embolized using three Target® XXL (6 × 40 mm, 5 × 20 mm) and two Target® XL SOFT (4 × 12 mm) coils (Stryker Inc., Tokyo, Japan). One month later, the fistulas arising separately from the left coronary artery were embolized. After the procedures, the major shunt flow disappeared angiographically, and Qp/Qs significantly decreased to 1/1.2. Additionally, the fractional flow reserve of the left coronary artery increased from 0.79 to 0.93, and cardiopulmonary exercise testing showed an improvement in his exercise tolerance.

Discussion
In similar cases, a surgical procedure with ligation of the CPFs combined with resection of a small aneurysm and coronary artery bypass grafting would normally have been considered the best approach. However, endovascular treatment targeting only the fistulas was a superior strategy considering the patient’s age. The coil embolization technique effectively controlled the shunt flow of the CPFs. This technique is considerably less invasive than surgical therapy.
Psychiatric morbidity and work participation in patients with congenital ventricular septal defects: a case-controlled study
Authors: Eckerström Filip , Hjortdal Vibeke Elisabeth , Rask Charlotte Ulrikka , Nyboe Camilla 
Published: January 2024

Abstract

Background
The burden of psychiatric morbidity, level of education, and work participation are currently unknown in patients with congenital ventricular septal defects (VSD).

Methods and results
In a Danish population-based cohort study using nationwide medical registries, the burden of psychiatric disorders, use of psychotropic agents, level of education, and work participation were examined in patients with isolated congenital VSD and controls from the general population matched by age and sex. Subjects with known chromosomal abnormalities were excluded. To compute estimates, Cox proportional regression model, Fine and Gray's competing risk regression, and Kaplan–Meier failure function were used. We included 8006 patients and 79 568 controls born before 2018. Median follow-up was 23 years. Compared with controls, patients with VSD displayed a hazard ratio (HR) of 1.24 [95% confidence interval (CI): 1.17–1.32] for any psychiatric disorder where the hazard for intellectual disabilities was most pronounced [HR of 3.66 (95% CI: 2.98–4.50)]. The use of psychotropic agents was higher in patients compared with controls [HR 1.14 (95% CI: 1.09–1.20)]. The work participation was lower in patients with VSD compared with controls (P &lt; 0.001) and was lower in patients with VSD with a psychiatric disorder compared with those without (P &lt; 0.001). The 40-year cumulative incidence of permanent social security benefits was 29% in patients with psychiatric disorders (vs. 21% in controls with psychiatric disorders) and 8% in patients without psychiatric disorders (vs. 4% in controls).

Conclusion
Patients with isolated VSD suffer from a higher burden of psychiatric disorders and display lower work participation compared with matched controls from the general Danish population. It is important to consider longer-term impacts on mental health, education, and subsequent employment in patients with VSD, in addition to cardiovascular effects, as these factors severely affect quality of life and have direct socioeconomic implications on an individual and societal level.
Use of Aprotinin versus Tranexamic Acid in Cardiac Surgery Patients with High-Risk for Excessive Bleeding (APACHE) trial: a multicentre retrospective comparative non-randomized historical study
Authors: Gallo Eloïse , Gaudard Philippe , Provenchère Sophie , Souab Fouzia , Schwab Anaïs , Bedague Damien , de La Barre Hugues , de Tymowski Christian , Saadi Laysa , Rozec Bertrand , Cholley Bernard , Scherrer Bruno , Fellahi Jean-Luc , Ouattara Alexandre ,   APACHE investigators, Imbault Julien , Cadier Gaspard , Beurton Antoine , Mion Stefano , Besnard Thibaud , Voulgaropoulos Julia , Gouezel Corentin , Mellano Vincent , Portefaix Hadrien , Pambet Hadrien , Fohlen Baptiste , Zlotnik Diane , Veli Manuela 
Published: January 2024

Abstract

OBJECTIVES
Following the reintroduction of aprotinin into the European market, the French Society of Cardiovascular and Thoracic Anaesthesiologists recommended its prophylactic use at half-dose for high-risk cardiac surgery patients. We examined whether the use of aprotinin instead of tranexamic acid could significantly reduce severe perioperative bleeding.

METHODS
This multicentre, retrospective, historical study included cardiac surgery patients treated with aprotinin or tranexamic acid between December 2017 and September 2020. The primary efficacy end point was the severe or massive perioperative bleeding (class 3–4 of the universal definition of perioperative bleeding). The safety secondary end points included the occurrence of thromboembolic events and all-cause mortality within 30 days after surgery.

RESULTS
Among the 693 patients included in the study, 347 received aprotinin and 346 took tranexamic acid. The percentage of patients with severe or massive bleeding was similar in the 2 groups (42.1% vs 43.6%, Adjusted odds ratio [ORadj] = 0.87, 95% confidence interval: 0.62–1.23, P = 0.44), as was the perioperative need for blood products (81.0% vs 83.2%, ORadj = 0.75, 95% confidence interval: 0.48–1.17, P = 0.20). However, the median (Interquartile range) 12 h postoperative blood loss was significantly lower in the aprotinin group (383 ml [241–625] vs 450 ml [290–730], P &lt; 0.01). Compared to tranexamic acid, the intraoperative use of aprotinin was associated with increased risk for thromboembolic events (adjusted Hazard ratio 2.30 [95% Cl: 1.06–5.30]; P = 0.04).

CONCLUSIONS
Given the modest reduction in blood loss at the expense of a significant increase in thromboembolic adverse events, aprotinin use in high-risk cardiac surgery patients should be based on a carefully considered benefit–risk assessment.
Host–gut microbiota interactions during pregnancy
Authors: Amato Katherine R , Pradhan Priyanka , Mallott Elizabeth K , Shirola Wesley , Lu Amy 
Published: January 2024

AbstractMammalian pregnancy is characterized by a well-known suite of physiological changes that support fetal growth and development, thereby positively affecting both maternal and offspring fitness. However, mothers also experience trade-offs between current and future maternal reproductive success, and maternal responses to these trade-offs can result in mother–offspring fitness conflicts. Knowledge of the mechanisms through which these trade-offs operate, as well as the contexts in which they operate, is critical for understanding the evolution of reproduction. Historically, hormonal changes during pregnancy have been thought to play a pivotal role in these conflicts since they directly and indirectly influence maternal metabolism, immunity, fetal growth and other aspects of offspring development. However, recent research suggests that gut microbiota may also play an important role. Here, we create a foundation for exploring this role by constructing a mechanistic model linking changes in maternal hormones, immunity and metabolism during pregnancy to changes in the gut microbiota. We posit that marked changes in hormones alter maternal gut microbiome composition and function both directly and indirectly via impacts on the immune system. The gut microbiota then feeds back to influence maternal immunity and metabolism. We posit that these dynamics are likely to be involved in mediating maternal and offspring fitness as well as trade-offs in different aspects of maternal and offspring health and fitness during pregnancy. We also predict that the interactions we describe are likely to vary across populations in response to maternal environments. Moving forward, empirical studies that combine microbial functional data and maternal physiological data with health and fitness outcomes for both mothers and infants will allow us to test the evolutionary and fitness implications of the gestational microbiota, enriching our understanding of the ecology and evolution of reproductive physiology.