bluuebunny/crossref_metadata_2025_split huggingface dataset:
War and Peace in Sermons of Stefan Yavorsky
Authors: Попович А.И. 
Published: December 2023

В статье исследуются и уточняются представления церковного лидера петровской эпохи Стефана Яворского в наиболее мифологизированный период его жизни (1707–1712). Преимущественно на материале неизученного рукописного проповеднического наследия выявляются особенности авторской провиденциалистской трактовки Северной войны как наказания общества за грехи и аналогичных объяснений отсутствия мира (и победы в войне). В отличие от панегирических текстов, свои обличительные проповеди Яворский наполнял морально-дидактическим содержанием, на-ходя многочисленные примеры нарушения христианских заповедей в России (в основном среди государственной элиты) и призывая слушателей к искоренению греха, покаянию и, по сути, общественному согласию (миру с ближним и Богом). Продемонстрировано, что знаменитая проповедь 1712 года на день св. Алексия, человека Божия, считающаяся кульминацией оппозиционных настроений Стефана Яворского, в основном содержала в себе ранее уже высказывавшиеся автором идеи и лишь подводила некий итог размышлениям проповедника о путях исправления общества.
The article examines the ideas of the Stefan Yavorsky, church leader of the Petrine era, in the most mythologized period of his life (1707–1712). The study reveals, mainly on the material of the unstudied manuscript preaching heritage, the features of the author's providential interpretation of the Great Northern War as a punishment of society for sins and similar explanations for the lack of peace and victory. Unlike panegyric texts, Yavorsky's accusatory sermons are filled with moral and didactic content. The preacher found numerous examples of violation of Christian commandments in Russia (mainly among the state elite) and called on listeners to eradicate sin, repentance and, in fact, social harmony (peace with neighbor and God). It is demonstrated that the famous sermon of 1712 on the day of St Alexius of Rome which is considered the culmination of Stefan Yavorsky's oppositional moods, mainly contained the ideas he had previously expressed and only summed up the preacher's reflections on ways to improve society.
Two Critiases and Atlantis: From the history of Athenian oligarchic thought
Authors: Суриков И.Е. 
Published: December 2023

Знаменитая легенда об Атлантиде (якобы привезенная в Афины из Египта Солоном), излагаемая в двух диалогах Платона («Тимей» и «Критий»), должна трактоваться в контексте политических и историософских дискуссий IV века до н.э. Мыслители этой эпохи хорошо помнили имевшее место в предыдущем столетии противостояние Афин и Спарты, закончившееся победой последней в Пелопоннесской войне. Интересно, что «развращенная морем» Атлантида в изображении Платона в ряде отношений чрезвычайно напоминает демократические Афины времен Перикла, а противостоящие ей и всячески идеализируемые «древнейшие Афины», напротив, четко ложатся в параллель с классической Спартой, консервативной, сухопутной и отнюдь не демократической, а иерархической. Таким образом, в диалогах проявляется олигархическая и лаконофильская система взглядов.
The famous legend of Atlantis (allegedly brought to Athens from Egypt by Solon) set forth in Plato’s two dialogues (Timaeusand Critias) should be treated in the context of political and historiosophical discussions of the 4th century B.C. Thinkers of that epoch remembered well opposition of Athens and Sparta, which took place in the previous century and was finished by the Spartan victory in the Peloponnesian War. It is interesting that Atlantis, “corrupted by the sea” as pictured by Plato, in a number of relations is extraordinarily reminiscent of the democratic Athens of Pericles’ times, and the “most ancient Athens”, which is opposed to it and idealized in every possible way, is, on the contrary, a clear parallel to the Classical Sparta – conservative, land-oriented and rather hierarchic than by any means democratic. In other words, the dialogues in question demonstrate an oligarchic and Laconophile system of views.
Household water insecurities and willingness to pay in Karachi
Authors: Khalil Sana , Bader Sheikh Sahaab , Jamal Ubaidullah , Khan Hassaan Furqan 
Published: December 2023

AbstractThis study explores challenges faced by households in obtaining safe water in Karachi, Pakistan. Analyzing data from a stratified random sample of 990 households across Karachi's six districts in 2021 -2022, we uncover disparities in pipeline coverage, sewage mixing, and water supply. Pipeline coverage is the highest in high-income neighborhoods (99%) and the lowest in low-income areas (71%). Low-income households experience more sewage mixing (76%) than high-income households (55.38%). Overall, 60% of households report frequent sewage mixing, and 30% have had someone in their household contract a water-borne illness in the last 6 months. Approximately half of the households are dissatisfied with water service, with a median daily water supply of just 8 min (equivalent to 56 minutes per week). We find that households that received some water supply in the past month are 11% more likely to pay their bills. Overall, households demonstrate a substantial willingness to pay (WTP) for improvements in the piped water system. The median monthly WTP is PKR 500 for low-income households, PKR 1,000 for middle-income households, and PKR 1,700 for high-income households. Our analysis emphasizes the importance of income-sensitive interventions in urban water supply management in the Global South.
Antiviral Potential of Traditional Unani Medicine with Special Emphasis on Dengue: A Review
Authors: Khan Muzayyana , Altamish Mohammad , Samal Monalisha , Srivastav Varsha , Insaf Areeba , Parveen Rabea , Akhtar Jamal , Krishnan Anuja , Ahmad Sayeed 
Published: December 2023

Abstract:Dengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history of using plant-based remedies. Several medicinal plant extracts have been studied for producing anti-dengue viral activity. AYUSH traditional systems provide a plethora of plants that have been reported to be useful in the treatment of fever. Single and compound plant- based formulations in natural form have been used in Unani holistic approaches. This review serves as a new approach to illustrate the most recent evidence regarding the antiviral activity of various plants by providing scientific proof and also to validate the traditional formulations as effective treatments in dengue fever for global acceptance.
Novel Targets and Drug Delivery System in the Treatment of
Postoperative Pain: Recent Studies and Clinical Advancement
Authors: Satapathy Trilochan , Singh Gulab , Pandey Ravindra Kumar , Shukla Shiv Shankar , Bhardwaj Shiv Kumar , Gidwani Beena 
Published: December 2023

Abstract:
Pain is generated by a small number of peripheral targets. These can be made more sensitive
by inflammatory mediators. The number of opioids prescribed to the patients can be reduced
dramatically with better pain management. Any therapy that safely and reliably provides extended
analgesia and is flexible enough to facilitate a diverse array of release profiles would be useful for
improving patient comfort, quality of care, and compliance after surgical procedures. Comparisons
are made between new and traditional methods, and the current state of development has
been discussed; taking into account the availability of molecular and cellular level data, preclinical
and clinical data, and early post-market data. There are a number of benefits associated with
the use of nanotechnology in the delivery of analgesics to specific areas of the body. Nanoparticles
are able to transport drugs to inaccessible bodily areas because of their small molecular size.
This review focuses on targets that act specifically or primarily on sensory neurons, as well as inflammatory
mediators that have been shown to have an analgesic effect as a side effect of their anti-
inflammatory properties. New, regulated post-operative pain management devices that use existing
polymeric systems were presented in this article, along with the areas for potential development.
Analgesic treatments, both pharmacological and non-pharmacological, have also been discussed.
Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development
Authors: Rezaei Maryam , Shakibaie Mehdi , Mohaqeq Alia , Khoramroudi Sana , Mohaqiq Zabihullah , Aschner Michael , Samarghandian Saeed , Farkhondeh Tahereh 
Published: December 2023

Background:
Silver nanoparticles (Ag-NPs) have garnered significant
attention in recent years due to their therapeutic effects. Curcumin (CUR) has been
utilized as a coating agent for synthesizing Ag-NPs, intended to act as a potential drug.

Objective::
This study was designed to evaluate the safety and efficacy of curcuminsynthesized
silver nanoparticles on rats exposed to chlorpyrifos (CPF) during their
pubertal development.

Methods:
Forty-two male Wistar rats, 23 days old, were selected and randomly
divided into 7 groups (n=6) as follows: positive control, negative control, CPF (5
mg/kg), silver nanoparticles synthesized using curcumin at 40 μg/kg (CUR-Ag-NPs
40), CUR-Ag-NPs 80, CPF+ CUR-Ag-NPs 40, CPF+ CUR-AgNPs 80. All treatments
were administered via gavage for 30 days. At the end of the study, rats were
anesthetized using ketamine (50 mg/kg), and xylazine, (10 mg/kg) and blood was
collected from the heart for serum analysis of liver enzymes, urea, and creatinine.

Results:
Liver and kidney tissues were isolated for histopathological analysis. No
significant differences were observed in serum levels of AST, ALT, and ALP enzymes
as well as urea and creatinine levels among the different groups. Light microscopy
observation revealed multifocal inflammatory mononuclear cell subsets in liver tissue
associated with mild inflammatory mononuclear cell infiltration in the portal region in
CPF, CUR-Ag-NPs 40, CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40, and CPF+CUR-Ag-
NPs 80 groups. Histological examination of kidney tissue showed degenerative
changes in the tubular epithelium, congestion, and mild infiltration of mononuclear
inflammatory cells in the renal interstitial tissue in the CPF group, CUR-Ag-NPs 40,
CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40 and CPF+CUR-Ag-NPs 80 groups.

Conclusion:
This study failed to establish the safety and efficacy of CUR-Ag-NP at 40
and 80 μg/kg in prepubertal rats exposed to CPF. However, further studies should be
conducted to thoroughly characterize the efficacy of CUR-Ag-NP in developmental
animal models.
Assessment of the Roles of Magnesium and Zinc in Clinical Disorders
Authors: Guzmán David Calderón , Brizuela Norma Osnaya , Herrera Maribel Ortiz , Peraza Armando Valenzuela , Garcia Ernestina Hernández , Mejía Gerardo Barragán , Olguin Hugo Juarez 
Published: December 2023

Abstract:
The ability and facility of magnesium (Mg2+) and zinc (Zn2+) to interact with phosphate
ions confer them the characteristics of essential trace elements. Trace elements are extremely
necessary for the basic nucleic acid chemistry of cells of all known living organisms.
More than 300 enzymes require zinc and magnesium ions for their catalytic actions, including
all the enzymes involved in the synthesis of ATP. In addition, enzymes such as isomerases, oxidoreductases,
lyases, transferases, ligases and hydrolases that use other nucleotides to synthesize
DNA and RNA require magnesium and zinc. These nucleotides may trigger oxidative damage or
important changes against free radicals. In the same way, nucleotides may play an important role
in the pathophysiology of degenerative diseases, including in some clinical disorders, where vascular
risk factors, oxidative stress and inflammation work to destabilize the patients` homeostatic
equilibrium. Indeed, reduced levels of zinc and magnesium may lead to inadequate amount of
antioxidant enzymes, and thus, acts as an important contributing factor for the induction of oxidative
stress leading to cellular or tissue dysfunction. Hence, the development of zinc or magnesium
enzyme inhibitors could be a novel opportunity for the treatment of some human disorders.
Therefore, the objective of the present work was to assess the clinical benefits of zinc and magnesium
in human health and their effects in some clinical disorders.
A Novel Deep Learning Model for Drug-drug Interactions
Authors: Abdul Raheem Ali K. , Dhannoon Ban N. 
Published: December 2023

Introduction:
Drug-drug interactions (DDIs) can lead to adverse events and compromised
treatment efficacy that emphasize the need for accurate prediction and understanding
of these interactions.

Methods:
in this paper, we propose a novel approach for DDI prediction using two separate
message-passing neural network (MPNN) models, each focused on one drug in a pair. By capturing
the unique characteristics of each drug and their interactions, the proposed method aims
to improve the accuracy of DDI prediction. The outputs of the individual MPNN models combine
to integrate the information from both drugs and their molecular features. Evaluating the
proposed method on a comprehensive dataset, we demonstrate its superior performance with an
accuracy of 0.90, an area under the curve (AUC) of 0.99, and an F1-score of 0.80. These results
highlight the effectiveness of the proposed approach in accurately identifying potential drugdrug
interactions.

Results:
The use of two separate MPNN models offers a flexible framework for capturing drug
characteristics and interactions, contributing to our understanding of DDIs. The findings of this
study have significant implications for patient safety and personalized medicine, with the potential
to optimize treatment outcomes by preventing adverse events.
Conclusion: Further research and validation on larger datasets and

Conclusion:
Further research and validation on larger datasets and real-world scenarios are necessary
to explore the generalizability and practicality of this approach.
DeepTransformer: Node Classification Research of a Deep Graph Network on an Osteoporosis Graph based on GraphTransformer
Authors: Liu Yixin , Jiang Guowei , Sun Miaomiao , Zhou Ziyan , Liang Pengchen , Chang Qing 
Published: December 2023

Background:
Osteoporosis (OP) is one of the most common diseases in the elderly
population. It is mostly treated with medication, but drug research and development have the
disadvantage of taking a long time and having a high cost.

Objective:
Therefore, we developed a graph neural network with the help of artificial intelligence
to provide new ideas for drug research and development for OP.

Methods:
In this study, we built a new osteoporosis graph (called OPGraph) and proposed a
deep graph neural network (called DeepTransformer) to predict new drugs for OP. OPGraph is a
graph data model established by gathering features and their interrelationships from a vast
amount of OP data. DeepTransformer uses GraphTransformer as its foundational network and
applies residual connections for deep layering.

Results:
The analysis and results showed that DeepTransformer outperformed numerous models
on OPGraph, with area under the curve (AUC) and area under the precision-recall curve
(AUPR) reaching 0.9916 and 0.9911, respectively. In addition, we conducted an in vitro validation
experiment on two of the seven predicted compounds (Puerarin and Aucubin), and the results
corroborated the predictions of our model.

Conclusion:
The model we developed with the help of artificial intelligence can effectively reduce
the time and cost of OP drug development and reduce the heavy economic burden brought
to patient's family by complications caused by osteoporosis.
Recent Patents on Solid Dispersions Emphasize Promising Benefits in Solubility Enhancement of Poorly Water-soluble Drugs
Authors: Saini Manisha , Bhatt Shailender , Dureja Harish , Solanki Neeta 
Published: December 2023

Background:
In the development of drug delivery systems, drugs' solubility remains the
most challenging constraint. Many newly synthesized chemical compounds are available, but they
involve low solubility and poor permeability restrictions. Among various drug delivery systems, the
utilization of solid dispersion technologies has become more focused due to their promising benefits.

Objective:
This technology has attracted extensive attention for dissolution rate improvement along
with substantial bioavailability enhancement of poorly water-soluble drug candidates.

Methods:
Many approaches have been employed for preparing solid dispersions, such as the melting
method, hot melt extrusion, solvent evaporation process, fusion and kneading method, spray drying
technique, co-grinding and freeze drying, supercritical fluid technology, etc.

Results:
A wide variety of hydrophilic and hydrophobic materials are available as carriers, which are
employed in the formulation of solid dispersions. Depending on the carrier characteristics, immediate-
release solid dispersions and/or controlled-release solid dispersions can be formulated. Multiple
hydrophilic materials have been explored for heightening dissolution features with enhanced bioavailability
of poorly water-soluble drug molecules. The availability of commercially available products
further validates the utility of solid dispersion technology in drug delivery systems.

Conclusion:
In the current manuscript, an attempt has been made to highlight the comprehensive
development techniques, characterization techniques, recent solid dispersion technologies, clinical
trial studies, and patented technology, along with studies heightening the dissolution behavior of
numerous poorly aqueous soluble drugs. The major stability issues affecting the suitability of solid
dispersions are also discussed.
Monitoring Kesehatan Remaja Berbasis Elektronik
Authors: Rosita Riska , Sari Fitriana Yuni Permana , Suryadi Agung , Pribadie Laras Setya , Demir Emine , Stone Selina 
Published: December 2023

Latar Belakang: Kesehatan remaja merupakan hal yang sangat penting untuk diperhatikan. Permasalahan kesehatan remaja seperti anemia, kurang energi kronis (KEK), obesitas, dan tingginya angka pernikahan dini telah berkontribusi pada kejadian stunting dan memicu penyakit degeneratif. Oleh karena itu, perlu adanya sistem monitoring kesehatan remaja melalui aplikasi website untuk menekan angka kesakitan remaja dan mengurangi resiko melahirkan anak stuntingTujuan: Penelitian ini bertujuan untuk menghasilkan media monitoring kesehatan remaja berbasis elektronik agar mampu menyajikan informasi yang lengkap, akurat, dan tepat waktuMetode: Desain penelitian yang digunakan adalah kualitaif dengan pendekatan Rapid Application Development (RAD) yang terdiri atas perencanaan, workshop desain, dan implementasi. Populasi penelitian ini adalah kader kesehatan di Posyandu Remaja Sondakan, sedangkan sampel yang digunakan adalah total populasi yaitu sejumlah 5 orang.Hasil: Aplikasi posyandu remaja dapat digunakan untuk memantau BMI, LILA dan hasil pemeriksaan darah.Laporan data dapat disajikan dalam bentuk grafik dan dicetak. Tingkat kelayakan berdasarkan PIECES diperoleh skor 89,8%.Kesimpulan: Pemeriksaan kesehatan remaja dapat dilakukan dengan mudah melalui grafik sebagai pemantauan hasil pemeriksaan. Pada sistem analisis menunjukan 89,9% telah layak digunakan dalam mendeteksi kondisi remaja yang tidak normal, sehingga bidan dapat segera memberikan pendidikan kesehatan, pengobatan, atau terapi. Bagi peneliti selanjutnya bisa mengembangkan sistem monitoring kesehatan remaja berbasis android.
O Slam como recurso de valorização e construção de identidades dissidentes em sala de aula: relato de experiência
Authors: Santos Maria Alcione dos , Silva Rafaela Martins da , Borges Lorena Araújo de Oliveira , Meniconi Flávia Colen 
Published: December 2023

Freire (1985) defende a importância da valorização do “mundo” do educando e sua relação com o processo educacional, enfatizando o relacionamento entre os conteúdos e a realidade das/os estudantes como forma de possibilitar caminhos mais significativos de aprendizagem. A partir dessa perspectiva, objetivamos apresentar um relato de experiência de uma professora de uma escola estadual na cidade de Arapiraca (AL), acerca do trabalho com o Slam em sala de aula. A escolha do gênero textual fundamenta-se no uso do letramento crítico e decolonial no contexto de ensino. Como aporte teórico, baseamo-nos em Freire (1985), Street (2014), Cosson (2009), dentre outros, para pensar os letramentos, Quijano (1992) para abordar a decolonialidade, e Hall (2016) para conceituar a noção de identidades. Como resultados da pesquisa, observamos grandes contribuições do gênero literário Slam para as aulas de literatura e para a formação da identidade do sujeito leitor crítico, reflexivo e decolonial, uma vez que o trabalho desenvolvido contribuiu para o exercício do respeito e da aceitação das diferentes culturas e sujeitos.
Forward-Looking Sustainability Information and Financial Analysts
Authors: Hertl Isabel C. , Maniora Janine 
Published: December 2023

ABSTRACT
This paper empirically examines the relationship between forward-looking environmental and social information in sustainability reports (FLSI) and financial analysts’ forecast accuracy. To provide contextual insights, we conduct semistructured interviews with financial analysts. We find that FLSI quantity, measured by FLSI words and scope, and FLSI quality, measured by the precision, horizon, and direction of the environmental or social forecast, are associated with greater earnings forecast accuracy for short-horizon forecasts. Specifically, the precision and direction of FLSI affect analysts’ short- and midhorizon forecasts. Our results hold only for environmental FLSI and FLSI in externally assured sustainability reports. However, the results indicate that the provision of economic information in sustainability reports does not affect analyst forecasts. Collectively, our findings carry far-reaching implications for practitioners and—in particular—regulators around the world by shedding light on the potential costs and benefits of the new European Corporate Sustainability Reporting Directive (CSRD).
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M40; M41.
Reliance on External Assurance in Regulatory Monitoring
Authors: Gopalan Yadav K. , Imdieke Andrew J. , Schroeder Joseph H. , Stuber Sarah B. 
Published: December 2023

ABSTRACT
We exploit a regulatory change to examine whether bank regulator strictness is affected when regulators no longer rely on external assurance. In the absence of external assurance, we find that banks report higher nonaccrual loans, higher troubled debt restructurings, and both a timelier loan loss provision and higher quality allowance for loan loss reserve. Further, regulators spend more days performing targeted bank examinations for banks affected by the regulatory change. We do not find evidence of operational deterioration, but rather the findings are consistent with increased regulator strictness over the reporting of problem assets, particularly during targeted examinations. Overall, our results suggest that regulators become stricter when they can no longer rely on the work of external auditors and that third-party assurance is an imperfect substitute for direct regulatory monitoring.
Data Availability: Bank regulatory rating and examination dates are confidential and were obtained from the Federal Reserve Bank of St. Louis. All other data are available from the public sources cited in the text.
JEL Classifications: G21; G28; M42.