bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timpanoplasti ve Timpanomastoidektomi; 5 Yıllık Sonuçlarımız
Authors: KURU Aykut , KANTEKİN Yunus , BULUT ÇÖBDEN Serap , KAYA Altan 
Published: November 2023

Amaç: Araştırmanın amacı kliniğimizde kronik otitis media (KOM) nedeniyle timpanoplasti ve timpanomastoidektomi uygulanan
hastalarda cerrahi sonuçlarımızı greft başarısı ve odyolojik açıdan güncel literatüre göre değerlendirmektir.

Gereç ve Yöntemler: Kulak Burun Boğaz Kliniğimizde Mayıs 2018- Mayıs 2023 tarihleri arasında KOM nedeniyle genel anestezi
altında timpanoplasti ve timpanomastoidektomi uygulanan 62 hasta çalışmaya dahil edilmiştir. Hastaların preoperatif anamnez,
fizik muayene ve odyolojik değerlendirmeleriyle; postoperatif süreçteki işitme testleri ve zar muayeneleri retrospektif olarak yaş ve
cinsiyet değişkenleri dahil edilerek istatistiki olarak değerlendirilmiştir.

Bulgular: Hastaların ortalama takip süresi 9.9 aydır. Preoperatif ve postoperatif hava kemik aralığı (HKA) değerlendirmesinde postoperatif işitme sonuçlarında istatistiksel olarak anlamlı iyileşme saptanmıştır (p
Correlation of CD133 Expression with Tumor Location and Lymph Node Involvement in Colorectal Carcinoma
Authors: Adelia Rachmita Prima , Hilbertina Noza , Yenita Yenita , Agus Salmiah , Suchitra Avit , Yetti Husna 
Published: November 2023

Introduction
Colorectal carcinoma (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer-related death. Ongoing efforts to investigate new treatment strategies for CRC include understanding CSC (Cancer Stem Cells) involvement. CSC is a group of tumor cells with stem cell characteristics that can play a role in metastasis, recurrence, and therapeutic resistance. This study aims to determine the correlation of CD133 expression as a CSC marker in CRC with tumor location and lymph node involvement in CRC.
Methods
This research is a cross-sectional study. The research sample obtained as many as 50 cases of paraffin blocks originating from resection. Immunohistochemical staining was performed to assess CD133 expression. Chi-square test statistical analysis was carried out with a p-value <0.05, considered significant.
Results
This study found that CD133 expression was higher in tumors located in the rectum compared to distal and proximal colon, 56%, 28%, and 16%, respectively. Statistically, there is a significant correlation between CD133 expression and lymph node involvement in CRC (p-value = 0.048).
Conclusions
There is a significant correlation between CD133 expression and lymph node involvement in CRC. Unfortunately, there was no statistically significant correlation between CD133 expression and tumor location. More extensive studies are needed to establish CD133 as a test performed on every patient with CRC.
Transtorno do déficit de atenção com hiperatividade (TDAH): consequências e opções de tratamento medicamentoso
Authors: Devenci Guilherme Vendruscolo , Quintino Vinícius , Nhoatto Paola , Devenci Eduardo Vendruscolo , Quintino Caroline , Annoni Gustavo Matge , Locatelli Claudriana , Luz Karine 
Published: November 2023

O Transtorno do Déficit de Atenção e Hiperatividade (TDAH) é caracterizado por uma tríade exacerbada de desatenção, desorganização e impulsividade, com impactos desde a infância até a idade adulta. Objetivo: Abordar as opções de tratamento medicamentoso do TDAH em crianças, juntamente com as consequências caso a patologia não seja tratada. Metodologia: pesquisa qualitativa, mediante revisão narrativa através de buscas na base de dados Biblioteca Virtual em Saúde (BVS) e material complementar de livros. Fez-se uso de descritores “TDAH”, “Tratamento do Déficit de Atenção com Hiperatividade”, “Tratamento Farmacológico”, “Farmacoterapia” e “Crianças”, critérios de inclusão: trabalhos em português, publicados nos últimos 5 anos que abordaram o tema, critérios de exclusão: texto completo indisponível ou não disponíveis de forma gratuita. Resultados: foram encontrados 190 trabalhos, dos quais 10 foram incluídos na revisão; desses, cinco abordam questões relacionadas ao impacto do TDAH e outros cinco abordam a farmacoterapia após leitura de seus resumos. Os trabalhos remanescentes foram excluídos por não contemplarem os objetivos da pesquisa. Conclusão: Apesar de o TDAH causar impactos negativos em diferentes áreas do desenvolvimento de seus portadores, o transtorno possui tratamento farmacológico consideravelmente efetivo e seu principal representante é o Metilfenidato. O diagnóstico precoce associado a intervenções adequadas pode reduzir os impactos do TDAH.
A saúde mental dos indivíduos LGBTQIAPN+ em meio a pandemia de COVID-19
Authors: Da Costa Ermeson Dias , De Araújo Marcos Vinícius Barbosa , De Souza Júlio César Pinto 
Published: November 2023

A pandemia de COVID-19 trouxe levou a drásticas mudanças na rotina da sociedade, alterando as formas de contato e interação social. Historicamente, a comunidade LGBTQIAPN+ é bastante afetada pela discriminação social que afeta negativamente a saúde mental dos indivíduos que a pertencem, levando a consequências como: ansiedade, depressão e até mesmo suicídio. O objetivo deste trabalho foi compreender as mudanças na saúde mental dos indivíduos LGBTQIAPN+ na pandemia de COVID-19. Foi realizada uma revisão sistemática de literatura realizada por meio de pesquisa em revistas eletrônicas, livros e na legislação pertinente ao assunto. Foram selecionados onze artigos versando sobre o tema. Infere-se que no período da pandemia de Covid-19 houve maiores níveis de ansiedade e estresse geral, sendo maiores em indivíduos LGBTQIAPN+ que já possuíam fatores pré-existentes. Além disso, é de fundamental a importância o acesso a psicólogos e outros profissionais de saúde durante e após períodos de pandemia.
Analysis of Railway Traffic Capacity in Bandung - Cicalengka
Authors: Raharjanto Yunanda 
Published: November 2023

Theoretical Framework: Constructing a double track and revitalizing or upgrading stations on the Kiaracondong-Cicalengka segment, the Bandung-Cicalengka route has changed routes and stations.
Purposes: The research objective, which is the focus of this study, is the analysis of cross capacity on the Bandung - Cicalengka railway line, the Kiaracondong - Cicalengka segment.

Method: The materials in this research are secondary data and primary data. Secondary data is done by taking inventory of existing data at PT. Kereta Api (Persero) is the operator, and the government, the Directorate General of Railways of the Ministry of Transportation, is the regulator. Primary data was collected by conducting direct surveys at the research location.
Results: The study results show that, theoretically, the calculation of railway traffic capacity for each road plot on the Bandung - Cicalengka route has yet to experience saturation and can be added to train trips as needed.
Linking organizational justice and knowledge sharing: An empirical investigation of SMEs in Vietnam
Authors: Nguyen Thi-Trang-Nhung , Vu Manh-Cuong , Nguyen Thi-Nguyen-Hong , Pham Viet-Dung , Luu Thi-Minh-Ngoc , Hoang Thi-Huong 
Published: November 2023

Purpose: The current study aims to investigate the mediating role of Perceived Organizational Support (POS) and Employee Satisfaction (ES) on the relationship between Organizational Justice (OJ) and Knowledge Sharing (KS) in Vietnamese Small and Medium-sized Enterprises (SMEs).
Design/Methodology/Approach: The framework and hypotheses were examined using SEM on SPSS and AMOS software to analyse the data after receiving 489 valid responses from 73 SMEs in Vietnam.
Findings: Findings confirmed that OJ positively affects POS, ES and KS. POS and ES played a partly mediator role in the relationship between OJ and KS. Moreover, the relationship between POS and KS is mediated by ES.
Conclusion: OJ is a crucial and persistent concern for individuals especially within modern organizations. It is one of the key factors shaping the behavior of individual employees. Furthermore, KS behavior is a significant driver of organizational competitiveness and growth. It predicts higher organizational performance, innovation capabilities and fosters a sense of enjoyment and happiness in aiding others. However, most studies have only examined the direct relationship between OJ and KS. Consequently, the methods by which leaders affect people continue to be unclear and mostly hypothetical. Thus, it becomes essential to analyze the empirical impact of OJ on KS by considering the intermediate influence of Perceived Organizational Support (POS) and Employee Satisfaction (ES).
Practical Implications: This study provides knowledge about the reality of POS and ES and their mediating role in the relationship between OJ and KS which contributes to enriching the library overall and Vietnamese in particular in this subject.
Contribution to the Literature: The mediating effect of POS and ES between OJ and KS is one of the initial topics to be addressed in this study focusing on SMEs.
A CONTRIBUIÇÃO DO PSICÓLOGO NO PROCESSO DE ENSINO E APRENDIZAGEM: UMA REVISÃO SISTEMÁTICA
Authors: Ubarnes Leidy Sarai Garces , Santos Vera Lucia dos Anjos , Martins Gizelly de Carvalho 
Published: November 2023

Objetivos: compreender a contribuição do psicólogo escolar no processo de ensino e aprendizagem no desenvolvimento infantil. Os objetivos específicos são: Descrever a atuação do psicólogo escolar junto aos alunos no ensino infantil; compreender o papel do psicólogo escolar na relação família e escola; destacar como o psicólogo escolar pode atuar em conjunto com os professores das instituições de ensino. Metodologia: Esta pesquisa trata-se de uma revisão sistemática da literatura, no qual os instrumentos de pesquisa para a realização desse estudo consistem em bibliográfico, pois seu aporte consiste em estudos científicos publicado em revistas constituída por seis etapas: identificação do problema ou questionamento, estabelecimento de critérios de inclusão/exclusão de artigos (seleção da amostra), definição das informações a serem extraídas dos artigos selecionados, análise das informações, interpretação dos resultados e apresentação da revisão. Resultados: foram incluídos 20 estudos a revisão, e desse total 6 estudos foram publicados no ano de 2019, 2 estudos foram publicados no ano de 2020, 4 estudos foram publicados no ano de 2021, 5 estudos foram publicados no ano de 2022, e 3 estudos foram publicados no ano de 2023. Discussão: artigos encontrados tratavam sobre psicologia escolar, mas cada autor apresentou suas visões e análise a respeito do tema. Assim, as vertentes analisadas na concepção do psicólogo escolar compreendidas nessa pesquisa foram pautadas no entendimento das funções deste profissional no ambiente estudantil, destacando o seu papel na família, no processo de ensino e entre os educadores. Considerações finais: a atuação do psicólogo escolar está pautada na atenção ao aluno, mas também na atuação com os familiares, e também está ligada ao processo de ensino e à atuação em conjunto com os professores das instituições de ensino.
The impact of Board Experience on Firm Performance: Evidence from Pakistan
Authors: Sohail Amir , Yingbo Wang  , Wahid Raza  
Published: November 2023

This study shows that how Board experience as corporate governance Facets effect on firm performance (Evidence from Pakistan). The sample size of the study was 100 non-financial companies listed on Pakistan Stock Exchange selected through purposive sampling technique while covering the time period from 2010 to 2019. The result concluded that a significant relationship exists between Board working Experience (BWE) and Firm Performance. The result shows that increase the percentage of board working experience can better monitor all the activities of firms and avoid the firms to get higher debts which leads to better firm performance and mitigate the Effect of Default Risk. The importance of the study is that it highlights the different dimensions of female Board Member as corporate Governance facets which may be useful for investors before making any investment decisions. The existing literature is mostly related to the developed countries. In this view, this study may also have enhanced contribution in the literature because its results pertain to an emerging economy of Pakistan.
Multidisciplinary Approach to Deciphering Etoposide Infusion Reactions and Potential Role of Polyethersulfone Filter Membranes
Authors: Miles Nicholas , Masters Andi , Desta Zeruesenay , Goldman Jennifer L. , Suppes Sarah L. , Tillman Emma M. 
Published: November 2023

PURPOSE
Etoposide, a topoisomerase II inhibitor used clinically to treat cancer, has been associated with severe anaphylactic infusion related adverse drug reactions (ADRs). In a previous study we identified a hydrophilic polyethersulfone filter as a possible cause of increased rates of pediatric etoposide infusion reactions. In this multidisciplinary follow-up analytical study, we aimed to assess the chemical structure of etoposide after passing through the same hydrophilic polyethersulfone filter.

METHODS
An etoposide 0.4 mg/mL infusion was prepared under aseptic conditions and then passed through a standard IV infusion set with an in-line filter in place. Samples were taken in triplicate using a needle-less access system to include sampling sites directly from the IV bag port and from the IV tubing both before and after the in-line filter. Samples were diluted into mobile phase, then an aliquot was injected into a high-performance liquid chromatography mass spectrometry HPLC-MS (Thermo TSQ Quantum Ultra) system coupled to a Diode Array Detector (DAD) (Thermo Dionex Ultimate 3000). Etoposide was monitored using a selected reaction monitoring scan (SRM) of 606.2/228.8 and wavelengths of 210, 220, 254, and 280 nm for 30 minutes.

RESULTS
No detectable differences were observed upon comparing the three samples. Based on these results, a chemical change in etoposide resulting from an in-line filter is unlikely to be the primary cause of increased rates of infusion reactions.

CONCLUSION
Pharmacists working in healthcare systems, observe many ADRs, but rarely have the resources necessary to investigate the potential etiology or causality. This report highlights importance of multi-disciplinary collaboration to investigate serious ADRs.
Antineoplastic drug access in Thailand
Authors:   , Saerekul Pornsroung 
Published: November 2023

The access to antineoplastic drugs has been a major concern affecting cancer patients on treatment plan as well as treatment costs. This descriptive study aimed to assess and compare the situation of access to anticancer drugs between Thailand and benchmarked countries, and to explore determinants influencing the accessibility of antineoplastic drugs in Thailand. The data on drug registration information of antineoplastic medications approved during 1982 and April 2016 were acquired from websites of the drug regulatory agency of studied countries including Thailand, Singapore, Malaysia, US, UK, and EMA. The result showed that Thailand had registered 88 out of 180 active pharmaceutical ingredients (APIs) of antineoplastic listed by WHO, comparing with 130 APIs registered in USA, 119 in UK, 75 in EMA, 92 in Singapore, and 68 in Malaysia. Of 88 APIs registered in Thailand, 38 were listed under National List of Essential Medicine (NLEM) for patient access. The time lag, which was time difference between market authorization approval (MAA) date in Thailand and in the compared country, was reported that on average Thailand has anticancer drugs available in the market 37.26 months later than US, 4.52 months than UK, 12.22 months than EMA, 10.73 months than Singapore, and 6.51 months than Malaysia. Trend analysis illustrated that the market access of antineoplastic drugs has been improved overtime from 87.59 months during 1983-1990 to 23.62 months during 2007-2016. However, the longer waiting time for patient access was reported. It took 88.05 months on average for a product to be listed under the National List of Essential Medicine (NLEM) after registered in Thailand. The analysis on determinants of market access pointed that the only significant determinant explained market access of antineoplastic drugs was the novelty level. The API listed as the 2nd or 3rd me-too was found to enter Thai market faster than others of the same classification. The study concluded that market access of antineoplastic drugs in Thailand had been improved overtime and comparative with Singapore and Malaysia. It was recommended that the process for anticancer drugs to be listed under NLEM for broader patient access needed to be revised.
An in vitro virucidal efficacy of disinfectants against porcine circovirus type 2
Authors:   , Trang Nguyen 
Published: November 2023

The objective of this study was to evaluate in vitro the virucidal activity against PCV2b of nine commercial disinfectants which were divided into three groups consisting of oxidizing products, QAC and iodine products, and two chemical substances including an alkali agent and aldehyde agent. Each disinfectant was freshly diluted in distill water and hardness of water as conducting the disinfectant test procedure. Five percent of fetal bovine serum were added as organic matter. After mixing the disinfectant with the stock of PCV2b, the final concentrations were 0.5x, 1x, 2x of the products’ labelled dilutions. After 1, 10, 30-minute and 12-hour contact time between the virus and the disinfectant, the mixture was detoxified by flowing through a detoxification column. The infectivity of the collected virus was determined by indirect immunoperoxidase monolayer assay and indirect immunofluorescence assay. Viability of PCV2b was illustrated after 12-hour exposure to QAC products (disinfectants 6 and 7) and iodine products (disinfectants 8 and 9). PCV2b inactivation was found after 30-minute contacting with a combination of glutaraldehyde and QAC (disinfectants 4 and 5). Oxidizing products were the most effective disinfectants (disinfectants 1, 2 and 3) against PCV2b after 10-minute contact time. Of oxidizing products, a combination of potassium peroxomonosulfate and sodium dichloro isocyanurate (1:200), which significantly reduced PCV2b titer (5 log10TCID50ml-1) after 1-minute exposure, indicated the best virucidal product against PCV2b.
Sosialisasi dan Pelatihan Branding, Packaging dan Digital Marketing Untuk Meningkatkan Penjualan Produk UMKM Desa
Authors: Febianti Pepe , Faradila Firda , Ai Nurhakim Salsabilla , Zalizar Auliya , Indah Melani Silvia 
Published: November 2023

Pemahaman masyarakat untuk mampu memaksimalisasi sumber daya yang ada dengan tersistem masih kurang. Banyak UMKM yang belum memiliki nama atau merk produk, sehingga tidak bisa membuat logo untuk produk mereka sendiri. Desa Purwadadi adalah daerah yang berada di Kabupaten Subang Kecamatan Purwadadi. Pada kegiatan pengabdian ini penulis melakukan kegiatan sosialisasi dan pelatihan Branding, Packaging dan Digital marketing untuk meningkatkan penjualan UMKM. Sosialisasi dan pelatihan tersebut diikuti oleh beberapa Responden UMKM yang ada di Desa Purwadadi (pemilik UMKM). Pada kegiatan pengabdian ini penulis melakukan pendampingan dalam sosialisasi dan pelatihan tersebut dengan penelitian deskriptif metode pengumpulan data menggunakan tahapan wawancara dan observasi. Sehingga kesimpulan dari kegiatan pengabdian ini adalah masyarakat yang memiliki UMKM sudah mulai memahami mengenai digital marketing dengan baik karena metode sosialisasi dan pelatihan untuk mempermudah masyarakat dalam memahami materi. Implikasi penelitian ini diharapkan Pelaku UMKM yang menjadi target sosialisasi ini mampu menciptakan citra usaha (branding), packaging yang menarik dan digital marketing yang baik demi efisiensi dan efektifitas kinerja dari usaha yang dijalankannya.
National Security Problems Related To Ethno-religious Groups In The South Caucasus (Georgian Case)
Authors: Putkaradze Kakha , Japaridze Ioseb , Putkaradze Tamaz 
Published: November 2023

Georgia is a polyethnic country. Armenians, Azeris, Russians, Greeks, Kurds, Kists, Dagestanis and other ethnic-confessional groups live next to Georgians. Thus, the traditions of inter-ethnic relations have a long history in Georgia.
Multiethnicity is one of the most important factors in the democratic development of a society, but in certain geopolitical conditions it can also be dangerous. For centuries, the invaders pursued anti-Georgian demographicpolicies in Georgia, compactly displacing members of other ethnic groups to the border areas of states inhabited by the same ethnic group, and deliberately creating micro-islands of ethnic minorities. It is in these two micro-islands that conflict has already erupted, while the other two regions carry the risk of the conflict.
Identifying the risks facing the state, justifying the need for preventive measures, and integrating ethno-religious minorities into the common state is the main task of our research.
The methodological basis of the research is the universal scientific principles of objectivity, comprehensiveness and systematics, historical-comparative and historical-typological methods.
The factual materials presented in the article make clear the factors hindering the general state integration, the problems related to the functioning of the state language, the different foreign policy orientations of the ethnic groups.
The article highlights the qualitative issues of integration of ethnic minorities in Georgia, strengthening the teaching of the state language, protection of cultural values of ethno-religious minorities, raising the degree of their involvement in public, political and cultural life.
Optimization and Nutritional Analysis of Low Calorie Functional Shrikhand
Authors: Abirami K.  , Murugan B.  , Karthikeyan N.  , Nithyalakshmi V.  
Published: November 2023

Shrikhand is a fermented dairy product and it is well-known in the western half of India's southern peninsula. The high sugar content of shrikhand contributes to total energy intake; carbohydrates are the food group that both dieters and diabetics are most limited from eating. An attempt was made to develop shrikhand by substituting sugar with aqueous extracts of stevia and liquorice, followed by the addition of guava pulp and aqueous extracts of dragon fruit peel at various levels. Initially, sugar of 40% of chakka weight was substituted by aqueous extracts of stevia and liquorice in four different ratios viz., 75:12.5:12.5(T1), 50:25:25(T2), 25:37.5:37.5(T3), 0:50:50(T4) of sugar to aqueous extracts of stevia and liquorice with control (T0) in the ratio of 100:0:0 and the low calorie shrikhand was optimized. Then it was followed by the addition of guava pulp at different concentrations viz., 5% (TG1), 10% (TG2), 15% (TG3), 20% (TG4) of chakka weight and aqueous extract of dragon fruit peel of 5% (TD1), 10% (TD2), 15% (TD3), 20% (TD4) of chakka weight to incorporate fibre and antioxidant properties in shrikhand respectively. Using a 9-point hedonic scale, sensory qualities (colour and appearance, body and texture, flavour and overall acceptability) of the developed product were evaluated by the semi-trained panels. As a result of sensory evaluation, the shrikhand with 50:25:25 ratio of sugar to aqueous extract of stevia and liquorice, 15% of guava pulp of chakka weight and 10% of aqueous extract of dragon fruit peel of chakka weight scored the highest overall acceptability of 8.13±0.26, 8.49±0.14 and 8.33±0.49 respectively. The mean ± SE values of moisture, total solids, protein, fat, fibre, total ash content, carbohydrates and energy of the control were 54.43±0.03, 47.57±0.02, 10.56±0.09, 13.14±0.02, 0, 0.98±0.01, 20.89±0.07 and 224.03±4.15 whereas the corresponding average values of the functional shrikhand were 67.61±0.05, 32.39±0.01, 11.21±0.04, 2.39±0.03, 5.78±0.09, 0.99±0.02, 12.02±0.05 and 96.43±3.26 respectively.