bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson’s Disease Pathology
Authors: Alcalá-Zúniga Daphne , Espinoza-Torres Erika , Das Ranjit Kumar , Vargas Magaly , Maldonado Oscar , Benavides Omar , Manojkumar Arvind , de la Garza Roberto , Davila Natalia , Perez Isaac , Martinez Alejandro Hernandez , Roy Deepa , López-Juárez Alejandro , Zarei Masoud M. , Baker Kelsey A. , Gil Mario , Rodrigo Hansapani , de Erausquin Gabriel A. , Roy Upal 
Published: February 2024

AbstractParkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have investigated the protective role of EE on dopamine dysregulation and subsequent downregulation of DJ1 protein using in vitro and in vivo models of PD. Our study for the first time demonstrated that DJ1 expression has a direct correlation with dopamine downregulation in PD models and exposure to EE has a significant impact on improving the behavioral changes in PD mice. This research provides evidence that exercise in EE has a positive effect on PD without interfering with the current line of therapy.
Postmenopausal onset of androgen excess: a diagnostic and therapeutic algorithm based on extensive clinical experience
Authors: Luque-Ramírez M. , Nattero-Chávez L. , Rodríguez-Rubio Corona C. , Ortiz-Flores A. E. , García-Cano A. M. , Rosillo Coronado M. , Pérez Mies B. , Ruz Caracuel I. , Escobar-Morreale H. F. 
Published: February 2024

Abstract
Purpose
Postmenopausal hyperandrogenism is a rare condition that requires identifying those women bearing a life-threatening tumor. We aimed to study diagnostic work-up and management of postmenopausal androgen excess, proposing an algorithm for clinical decision supporting.

Methods
We conducted an observational cross-sectional study and longitudinal follow-up including 51 consecutive menopausal patients reported for hyperandrogenism between 2003 and 2023 to our clinics. We assessed diagnostic testing accuracy and performance by receiver operating characteristic curves, their respective areas under the curve (AUCROC), and 95% confidence intervals (95%CI), for distinguishing between benign and malignant conditions, and androgen excess source.

Results
Most commonly, postmenopausal hyperandrogenism derived from benign conditions such as ovarian hyperthecosis (n = 9). However, four (8%) patients had borderline/malignant tumors arising at the ovaries (n = 3) or adrenals (n = 1). These latter were more likely to develop virilization than those with benign disorders [specificity(95%CI)]: 0.87 (0.69; 0.92)]. Circulating total testosterone [AUCROC(95%CI): 0.899 (0.795; 1.000)] and estradiol [AUCROC(95%CI): 0.912 (0.812; 1.000)] concentrations showed good performances for discriminating between both conditions. Transvaginal-ultrasonography found two out of three potentially malignant ovarian neoplasms, and another was apparent on a pelvic computed tomography scan. An adrenal computed tomography scan also located an androgen-secreting carcinoma.

Conclusions
Clinical or biochemical features of an aggressive androgen-secreting tumor should lead to urgently obtaining a targeted imaging. At first, an abdominal-pelvic CT scan represents the best choice to perceive adrenal malignancy, and may identify aggressive ovarian tumors. When warning signs are lacking, a calm and orderly work-up allows properly addressing the diagnostic challenge of postmenopausal hyperandrogenism.
Christian Ecology in the Letter to the Hebrews
Authors: Costley Angela 
Published: February 2024

AbstractThis paper proceeds from a discourse analytical perspective and asks what we can learn from Hebrews 1-2 concerning the relationship of humanity to creation through Christ. First, the exordium is examined to reveal a descent–ascent motif for the incarnate Son who is the one through whom God creates (1:2) and who sustains everything by his powerful word (1:3). The paper then explains how the Son’s sacrificial activity is subsumed within this theology as we look at the catena of scriptural citations found in the rest of chapter 1, where the catena deepens the theology of the exordium by presenting the same events in reverse order. However, towards the end of the catena, when we would expect a reference to the Son and his having inherited a name greater than the angels (1:4), we instead hear about how the angels are sent to serve humanity who inherit salvation. This enables the discourse to move on to chapter 2 and the purpose of Christ’s descent to lead humanity heavenward to glory (2:10). This paper uncovers how that glory is the Son’s own glory and posits a process of theosis by which humanity shares in the Son’s sustaining role over creation.
14C DATING OF HISTORICAL JAPANESE MUSICAL INSTRUMENT SACKS
Authors: Yokoyama Misao , Sakamoto Minoru , Takaya Hikaru , Kanamori Kazuyoshi 
Published: February 2024

ABSTRACTThe radiocarbon (14C) dating method was applied to a survey of treasured items related to the ruins of the Imperial Residence in Anou, Nara Prefecture, which was one of the capitals of Japan during the 14th century. In this work, we dated two storage bags for Japanese musical instruments that are believed to be from the period of Emperor Go-Daigo who established the Southern Court. The 14C dating of these treasures proved that the musical instrument sacks are contemporaneous with the dating of the Imperial Residence ruins designated as an Important Cultural Property of Japan. In addition, there are limited surviving examples of silk fabrics from the Middle Ages compared to the Ancient and Early Modern periods, making this a valuable resource in the history of silk fabrics in Japan.
Social determinants of chronic diseases reporting among slum dwellers in Egypt
Authors: Abdel-Rahman Suzan , Khater Elsayed , Abdel Fattah Mohamed N. , Hussein Wafaa A. 
Published: February 2024

AbstractThe high prevalence of chronic diseases in urban slums poses increasing challenges to future social and economic development for these disadvantaged areas. Assessing the health status of slum residents offers guidance for formulating appropriate policies and interventions to improve slum residents’ health outcomes. This research aimed to identify the social determinants of chronic diseases reporting among slum dwellers in Egypt. A cross-sectional survey was conducted from March to December 2021 in three slum areas in Giza governorate, Egypt, including 3,500 individuals. We constructed an asset index and a welfare index to measure the economic status and living conditions of slum residents, respectively. We used these indices, along with demographic and socio-economic factors, as independent variables in the analysis. We modeled factors associated with health status using a two-level mixed logistic model to control the effects of slum areas and the potential correlation between household members. The study contributed significantly to a better understanding of the context in which slum dwellers live and the interlinkages among poor living conditions, low economic status, and health outcomes. The results showed a high rate of self-reported chronic diseases among adults aged 18 and older, reaching more than 22%, while it did not exceed 2.0% among children in the slum areas. Therefore, measuring the determinants of chronic diseases was limited to adults. The sample size was 2530 adults after excluding 970 children. The prevalence of chronic diseases among adults ranged between 16.3% in Zenin and 22.6% in Bein El Sarayat. Our findings indicated that low socio-economic status was significantly associated with reporting chronic diseases. Future policies should be dedicated to improving living conditions and providing necessary healthcare services for these vulnerable areas.
Seeing Santurbán through ISDS: A sociolegal case study of Eco Oro v. Colombia
Authors: Cotula Lorenzo , Perrone Nicolás M. 
Published: February 2024

AbstractThis article aims to enrich the emerging, multi-coloured tapestry of ‘international law in context’ through a study of how international economic law operates in complex investment-related disputes. Focusing on the Eco Oro v. Colombia investor-state arbitration, and drawing on both doctrinal analysis and sociolegal research, the study investigates how different actors make sense of the issues, of the dispute, and of the law. Besides shedding light on the neglected multi-actor, multi-layered dimensions of investment disputes, and on tensions between often incommensurable values, juxtaposing arbitral proceedings and underlying social realities highlights how investor-state arbitration involves a socio-political process of re-presenting actors, territory, the environment, and livelihoods through the prism of international arrangements that are primarily designed to protect foreign investment. The findings provide policy pointers on the need for systemic reform of international investment law, moving away from the predominant emphasis on investment protection and investor-state dispute settlement, towards a governance model that effectively considers the social, political, and environmental dimensions of foreign investment projects.
Malaria in pregnancy: Meta-analyses of prevalence and associated complications
Authors: Das Jai K. , Lakhani Sohail , Rahman Abdu R. , Siddiqui Faareha , Ali Padhani Zahra , Rashid Zainab , Mahmud Omar , Naqvi Syeda Kanza , Amir Naseem Hamna , Jehanzeb Hamzah , Kumar Suresh , Beg Mohammad Asim 
Published: February 2024

Abstract
This review aims to assess the prevalence of malaria in pregnancy during antenatal visits and delivery, species-specific burden together with regional variation in the burden of disease. It also aims to estimate the proportions of adverse pregnancy outcomes in malaria-positive women. Based on the PRISMA guidelines, a thorough and systematic search was conducted in July 2023 across two electronic databases (including PubMed and CENTRAL). Forest plots were constructed for each outcome of interest highlighting the effect measure, confidence interval, sample size, and its associated weightage. All the statistical meta-analysis were conducted using R-Studio version 2022.07. Sensitivity analyses, publication bias assessment, and meta-regression analyses were also performed to ensure robustness of the review. According to the pooled estimates of 253 studies, the overall prevalence of malaria was 18.95% (95% CI: 16.95–21.11), during antenatal visits was 20.09% (95% CI: 17.43–23.06), and at delivery was 17.32% (95% CI: 14.47–20.61). The highest proportion of malarial infection was observed in Africa approximating 21.50% (95% CI: 18.52–24.81) during ANC and 20.41% (95% CI: 17.04–24.24) at the time of delivery. Our analysis also revealed that the odds of having anaemia were 2.40 times (95% CI: 1.87–3.06), having low birthweight were 1.99 times (95% CI: 1.60–2.48), having preterm birth were 1.65 times (95% CI: 1.29–2.10), and having stillbirths were 1.40 times (95% CI: 1.15–1.71) in pregnant women with malaria.
The Pristine Inner Galaxy Survey (PIGS) V: a chemo-dynamical investigation of the early assembly of the Milky Way with the most metal-poor stars in the bulge
Authors: Sestito Federico , Venn Kim A. , Arentsen Anke , Aguado David 
Published: February 2024

AbstractThe investigation of the metal-poor tail in the Galactic bulge provides unique information on the early Milky Way assembly and evolution. A chemo-dynamical analysis of 17 very metal-poor stars (VMP, [Fe/H < – 2.0]) selected from the Pristine Inner Galaxy Survey was carried out based on Gemini/GRACES spectra. The chemistry suggests that the majority of our stars are very similar to metal-poor stars in the Galactic halo. Orbits calculated from Gaia EDR3 imply these stars are brought into the bulge during the earliest Galactic assembly. Most of our stars have large [Na,Ca/Mg] abundances, and thus show little evidence of enrichment by pair-instability supernovae. Two of our stars (P171457, P184700) have chemical abundances compatible with second-generation globular cluster stars, suggestive of the presence of ancient and now dissolved globular clusters in the inner Galaxy. One of them (P171457) is extremely metal-poor ([Fe/H < – 3.0]) and well below the metallicity floor of globular clusters, which supports the growing evidence for the existence of lower-metallicity globular clusters in the early Universe. A third star (P180956, [Fe/H]∼ – 2) has low [Na,Ca/Mg] and very low [Ba/Fe] for its metallicity, which are consistent with formation in a system polluted by only one or a few low-mass supernovae. Interestingly, its orbit is confined to the Galactic plane, like other very metal-poor stars found in the literature, which have been associated with the earliest building blocks of the Milky Way.
Stronger Oceanic CO2 Sink in Eddy‐Resolving Simulations of Global Warming
Authors: Couespel Damien , Lévy Marina , Bopp Laurent 
Published: February 2024

AbstractAccurately representing the ocean carbon cycle in Earth System Models (ESMs) is essential to understanding the oceanic CO2 sink evolution under CO2 emissions and global warming. A key uncertainty arises from the ESM's inability to explicitly represent mesoscale eddies. To address this limitation, we conduct eddy‐resolving experiments of CO2 uptake under global warming in an idealized mid‐latitude ocean model. In comparison with similar experiments at coarser resolution, we show that the CO2 sink is 34% larger in the eddy‐resolving experiments. 80% of the increase stems from a more efficient anthropogenic CO2 uptake due to a stronger Meridional Overturning circulation (MOC). The remainder results from a weaker reduction in CO2 uptake associated to a weaker MOC decline under global warming. Although being only a fraction of the overall response to climate change, these results emphasize the importance of an accurate representation of small‐scale ocean processes to better constrain the CO2 sink.
How Fault‐Normal and Shear‐Parallel Stiffness Influence Frictional Sliding Behavior
Authors: Eijsink Agathe M. , Ikari Matt J. 
Published: February 2024

AbstractThe potential of faults to show earthquake‐generating slip instabilities depends not only on the intrinsic frictional properties of the fault zone, but also on the elasticity of the surrounding material. A velocity‐weakening fault is expected to show increasingly unstable frictional behavior with decreasing local elastic stiffness around the fault zone. Fault zone roughness can cause slip in the shear direction to be accompanied by fault‐normal movement, modulated by fault‐normal elastic properties, however these effects are poorly understood. Here, we systematically vary the stiffness surrounding the fault in both the shear‐parallel and fault‐normal directions, to investigate the origin of slip instabilities and changes in friction constitutive properties. We confirm the transition from stable sliding through slow slip to stick‐slip due to reduced fault‐parallel stiffness, and that the occurrence of different types of slip events can be explained by the ratio between shear and critical stiffness. In contrast, reducing the fault‐normal stiffness produces stick‐slip instabilities under conditions where the conventional critical stiffness criterion predicts stable sliding, and does not produce transitional slow slip events. Our data suggest that: (a) the stability criterion for frictional slip should be modified to incorporate fault‐normal stiffness, and (b) the unexpected slip instabilities may represent wrinkle‐like slip pulses, possibly due to a stiffness asymmetry introduced by lowering the fault normal stiffness on one side of the fault. This implies that earthquakes may occur when the fault‐normal stiffness, or bulk modulus for natural faults, is decreased and/or asymmetric across the fault zone, both of which may be common in nature.
U.S. cereal rye winter cover crop growth database
Authors: Huddell Alexandra M. , Thapa Resham , Marcillo Guillermo S. , Abendroth Lori J. , Ackroyd Victoria J. , Armstrong Shalamar D. , Asmita Gautam , Bagavathiannan Muthukumar V. , Balkcom Kipling S. , Basche Andrea , Beam Shawn , Bradley Kevin , Canisares Lucas Pecci , Darby Heather , Davis Adam S. , Devkota Pratap , Dick Warren A. , Evans Jeffery A. , Everman Wesley J. , de Almeida Tauana Ferreira , Flessner Michael L. , Fultz Lisa M. , Gailans Stefan , Hashemi Masoud , Haymaker Joseph , Helmers Matthew J. , Jordan Nicholas , Kaspar Thomas C. , Ketterings Quirine M. , Kladivko Eileen , Kravchenko Alexandra , Law Eugene P. , Lazaro Lauren , Leon Ramon G. , Liebert Jeffrey , Lindquist John , Loria Kristen , McVane Jodie M. , Miller Jarrod O. , Mulvaney Michael J. , Nkongolo Nsalambi V. , Norsworthy Jason K. , Parajuli Binaya , Pelzer Christopher , Peterson Cara , Poffenbarger Hanna , Poudel Pratima , Reiter Mark S. , Ruark Matt , Ryan Matthew R. , Samuelson Spencer , Sawyer John E. , Seehaver Sarah , Shergill Lovreet S. , Upadhyaya Yogendra Raj , VanGessel Mark , Waggoner Ashley L. , Wallace John M. , Wells Samantha , White Charles , Wolters Bethany , Woodley Alex , Ye Rongzhong , Youngerman Eric , Needelman Brian A. , Mirsky Steven B. 
Published: February 2024

AbstractWinter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States. The dataset includes a total of 5,695 cereal rye biomass observations across 208 site-years between 2001–2022 and encompasses a wide range of agronomic, soils, and climate conditions. Cereal rye biomass values had a mean of 3,428 kg ha−1, a median of 2,458 kg ha−1, and a standard deviation of 3,163 kg ha−1. The data can be used for empirical analyses, to calibrate, validate, and evaluate process-based models, and to develop decision support tools for management and policy decisions.
Mapping urban form into local climate zones for the continental US from 1986–2020
Authors: Qi Meng , Xu Chunxue , Zhang Wenwen , Demuzere Matthias , Hystad Perry , Lu Tianjun , James Peter , Bechtel Benjamin , Hankey Steve 
Published: February 2024

AbstractUrbanization has altered land surface properties driving changes in micro-climates. Urban form influences people’s activities, environmental exposures, and health. Developing detailed and unified longitudinal measures of urban form is essential to quantify these relationships. Local Climate Zones [LCZ] are a culturally-neutral urban form classification scheme. To date, longitudinal LCZ maps at large scales (i.e., national, continental, or global) are not available. We developed an approach to map LCZs for the continental US from 1986 to 2020 at 100 m spatial resolution. We developed lightweight contextual random forest models using a hybrid model development pipeline that leveraged crowdsourced and expert labeling and cloud-enabled modeling – an approach that could be generalized to other countries and continents. Our model achieved good performance: 0.76 overall accuracy (0.55–0.96 class-wise F1 scores). To our knowledge, this is the first high-resolution, longitudinal LCZ map for the continental US. Our work may be useful for a variety of fields including earth system science, urban planning, and public health.
Carbon dioxide and cardiac output as major contributors to cerebral oxygenation during apnoeic oxygenation
Authors: Kaiser Heiko Andreas , Bauer Thomas , Riva Thomas , Greif Robert , Riedel Thomas , Theiler Lorenz , Nabecker Sabine 
Published: February 2024

AbstractApnoeic oxygenation has experienced a resurgence in interest in critical care and perioperative medicine. However, its effect on cerebral oxygenation and factors influencing it, have not yet been investigated in detail. By using near-infrared spectroscopy, we intended to provide further evidence for the safety of apnoeic oxygenation and to increase our understanding of the association between cerebral perfusion, haemodynamic, respiratory and demographic factors. In this secondary analysis of a prospective randomized controlled noninferiority trial, we recruited 125 patients, who underwent surgery under general anaesthesia with neuromuscular blockade. Arterial blood samples were taken every 2 min for a total of 15 min under apnoeic oxygenation with 100% oxygen. Near-infrared spectroscopy and cardiac output were continuously measured. Statistical analysis was performed using uni- and multivariable statistics. Ninety-one complete data sets were analysed. In six patients the SpO2 fell below 92% (predefined study termination criterion). The significant average increase of cerebral oxygenation was 0.5%/min and 2.1 mmHg/min for the arterial pressure of carbon dioxide (paCO2). The median cardiac output increased significantly from 5.0 l/min (IQR 4.5–6.0) to 6.5 l/min (IQR 5.7–7.5). The most significant effect on cerebral oxygenation was exhibited by the variable paCO2 and non-specific patient factors, followed by cardiac output and paO2. Apnoeic oxygenation proves to have a high safety profile while significantly increasing cerebral oxygenation, paCO2 and cardiac output. In reverse, NIRS might act as a reliable clinical surrogate of paCO2 and cardiac output during stable arterial oxygenation.
Host brain environmental influences on transplanted medial ganglionic eminence progenitors
Authors: Paterno Rosalia , Vu Thy , Hsieh Caroline , Baraban Scott C. 
Published: February 2024

AbstractInterneuron progenitor transplantation can ameliorate disease symptoms in a variety of neurological disorders. The strategy is based on transplantation of embryonic medial ganglionic eminence (MGE) progenitors. Elucidating how host brain environment influences the integration of interneuron progenitors is critical for optimizing this strategy across different disease states. Here, we systematically evaluated the influence of age and brain region on survival, migration, and differentiation of transplant-derived cells. We find that early postnatal MGE transplantation yields superior survival and more extensive migratory capabilities compared to transplantation during the juvenile or adult stages. MGE progenitors migrate more widely in the cortex compared to the hippocampus. Maturation to interneuron subtypes is regulated by age and brain region. MGE progenitors transplanted into the dentate gyrus sub-region of the early postnatal hippocampus can differentiate into astrocytes. Our results suggest that the host brain environment critically regulates survival, spatial distribution, and maturation of MGE-derived interneurons following transplantation. These findings inform and enable optimal conditions for interneuron transplant therapies.