bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain-derived neurotrophic factor gene polymorphism affects cognitive function and neurofilament light chain level in patients with subcortical ischaemic vascular dementia
Authors: Yao Xiaojuan , Yang Guotao , Fang Tingting , Tian Zhuo , Lu Yunyao , Chen Feifan , Che Ping , Chen Jingshan , Zhang Nan 
Published: October 2023

ObjectiveTo investigate the effects of brain-derived neurotrophic factor (BDNF) gene polymorphism on cognitive function, neuroimaging and blood biological markers in patients with subcortical ischaemic vascular dementia (SIVD).MethodsA total of 81 patients with SIVD were included. According to their BDNF gene polymorphism, the participants were divided into the Val/Val (n = 26), Val/Met (n = 35), and Met/Met (n = 20) groups. A comprehensive neuropsychological evaluation and multimodal brain MRI scan were performed. MRI markers for small vessel disease were visually rated or quantitatively analysed. Moreover, 52 patients were further evaluated with blood marker assays, including amyloid beta (Aβ), phosphorylated tau at threonine-181 (P-tau181), glial fibrillary acidic protein (GFAP), total tau (T-tau) and neurofilament light chain (NfL).ResultsThere were no significant differences in demographics, disease duration or MRI markers of small vessel disease between the three groups. Compared with the Val/Val and Val/Met groups, the Met/Met group showed worse performance in the verbal fluency test and higher levels of plasma NfL.ConclusionThe rs6265 polymorphism of the BDNF gene is associated with semantic language fluency in patients with SIVD. The Met genotype may be a risk factor for cognitive impairment and neuronal injury.
Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database
Authors: Yuan Min , Xiao Zhilong , Zhou Huangyan , Fu Anxia , Pei Zhimin 
Published: October 2023

BackgroundRecent evidence suggested that platelet-lymphocyte ratio (PLR) may play a role in the pathophysiology of intracerebral hemorrhage (ICH), but the results are controversial. This study aimed to explore the relationship between PLR and mortality in patients with ICH.MethodsAll data were extracted from the Medical Information Mart for Intensive Care (MIMIC) III database. The study outcome was 90-day mortality. Multivariable Cox regression analyses were used to calculate the adjusted hazard ratio (HR) with a 95% confidence interval (CI), and curve-fitting (restricted cubic spline) was used to assess the non-linear relationship.ResultsOf 1,442 patients, 1,043 patients with ICH were included. The overall 90-day mortality was 29.8% (311/1,043). When PLR was assessed in quartiles, the risk of 90-day mortality for ICH was lowest for quartile 2 (120.9 to &lt;189.8: adjusted HR, 0.67; 95% CI: 0.48–0.93; P = 0.016), compared with those in quartile 1 (&lt;120.9). Consistently in the threshold analysis, for every 1 unit increase in PLR, there was a 0.6% decrease in the risk of 90-day mortality for ICH (adjusted HR, 0.994; 95% CI: 0.988–0.999) in those with PLR &lt;145.54, and a 0.2% increase in 90-day mortality (adjusted HR, 1.002; 95% CI: 1.000–1.003) in participants with PLR ≥145.54.ConclusionThere was a non-linear relationship between PLR and 90-day mortality for patients with ICH, with an inflection point at 145.54 and a minimal risk at 120.9 to &lt;189.8 of PLR.
Truncated DNM1 variant underlines developmental delay and epileptic encephalopathy
Authors: Afsar Tayyaba , Huang Xiaoyun , Shah Abid Ali , Abbas Safdar , Bano Shazia , Mahmood Arif , Hu Junjian , Razak Suhail , Umair Muhammad 
Published: October 2023

BackgroundDevelopmental and epileptic encephalopathies (DEEs) signify a group of heterogeneous neurodevelopmental disorder associated with early-onset seizures accompanied by developmental delay, hypotonia, mild to severe intellectual disability, and developmental regression. Variants in the DNM1 gene have been associated with autosomal dominant DEE type 31A and autosomal recessive DEE type 31B.MethodsIn the current study, a consanguineous Pakistani family consisting of a proband (IV-2) was clinically evaluated and genetically analyzed manifesting in severe neurodevelopmental phenotypes. WES followed by Sanger sequencing was performed to identify the disease-causing variant. Furthermore, 3D protein modeling and dynamic simulation of wild-type and mutant proteins along with reverse transcriptase (RT)–based mRNA expression were checked using standard methods.ResultsData analysis of WES revealed a novel homozygous non-sense variant (c.1402G&gt;T; p. Glu468*) in exon 11 of the DNM1 gene that was predicted as pathogenic class I. Variants in the DNM1 gene have been associated with DEE types 31A and B. Different bioinformatics prediction tools and American College of Medical Genetics guidelines were used to verify the identified variant. Sanger sequencing was used to validate the disease-causing variant. Our approach validated the pathogenesis of the variant as a cause of heterogeneous neurodevelopmental disorders. In addition, 3D protein modeling showed that the mutant protein would lose most of the amino acids and might not perform the proper function if the surveillance non-sense-mediated decay mechanism was skipped. Molecular dynamics analysis showed varied trajectories of wild-type and mutant DNM1 proteins in terms of root mean square deviation, root mean square fluctuation and radius of gyration. Similarly, RT-qPCR revealed a substantial reduction of the DNM1 gene in the index patient.ConclusionOur finding further confirms the association of homozygous, loss-of-function variants in DNM1 associated with DEE type 31B. The study expands the genotypic and phenotypic spectrum of pathogenic DNM1 variants related to DNM1-associated pathogenesis.
Hematological characteristics and hepatobiliary complications of hereditary spherocytosis in a tertiary care pediatric center: optimizing diagnosis and care through local and international networks
Authors: Boaro Maria Paola , Reggiani Giulia , D’Agnolo Mirco , Munaretto Vania , Pozzebon Francesco , Trapanese Roberta , Martella Maddalena , Colombatti Raffaella 
Published: October 2023

BackgroundHereditary Spherocytosis (HS) is a rare, congenital red blood cell disorder presenting with variable clinical manifestations ranging from mild hemolytic anemia to severe anemia with hypersplenism and hepatobiliary complications.MethodsThe objectives of the study were to evaluate the diagnostic pathway of HS, the presence and management of hepatobiliary complications in pediatric patients with HS followed in a tertiary care center. The demographic, clinical, hematological information were retrieved from medical records of patients having at least 1 hematology visit between 2010 and 2020.ResultsForty-two patients were enrolled, 23 M. Mean age at onset of symptoms was 2.8 years, at diagnosis was 3.5 years. Anemia was the first manifestation in 73%; suspect of HS arose for all patients in first or second level outpatient clinics. Only 64% of patients performed two confirmation tests in the reference center. 28/42 had familiarity for HS; of the 13/42 who did not, only 47% performed further analysis. Sixteen patients developed gallbladder stones (40%), visible at the first ultrasound (5.6 years). Hemolytic crises and parvovirus infections were more frequent in patients with stones (53.6% vs. 26.1% and 63.6% vs. 28.6%, respectively). 10/16 (62.5%) underwent elective cholecystectomy: 8 had concomitant splenectomy.Conclusionsour study highlights the need to optimize the diagnostic pathway in networks of care involving general and specialized centers in order to reduce time to diagnosis and ensure that all patients receive confirmatory tests. A high frequency of hepatobiliary complications since young age was observed suggesting that screening with ultrasound should begin earlier
Effects of public reporting of prescription indicators on patient choices: evidence from propensity scores matching
Authors: Chen Manli , Zhang Xinping , Liu Chaojie , Chen Haihong , Wang Dan , Liu Chenxi 
Published: October 2023

Background: Public reporting on health providers’ performance (PRHPP) is increasingly used for empowering patients. This study aimed to test the effect of PRHPP using the theory of the consumer choice model.Methods: The study was conducted in 10 primary care institutions in Hubei province, China. Information related to the percentage of prescriptions requiring antibiotics, the percentage of prescriptions requiring injections, and average costs per prescription for each prescriber was calculated, ranked and displayed in a public place on a monthly basis. A questionnaire survey was undertaken on 302 patients 10 months after the initiation of the PRHPP, tapping into patient awareness, understanding, perceived value and use of the information in line with the theory of the consumer choice model. The fitness of data with the model was tested using structural equation modelling. The patients who were aware of the PRHPP were compared with those who were unaware of the PRHPP. The propensity score method (considering differences between the two groups of patients in age, gender, education, health and income) was used for estimating the effects of the PRHPP.Results: About 22% of respondents were aware of the PRHPP. Overall, the patients showed limited understanding, perceived value and use of the disclosed information. The data fit well into the consumer choice model. Awareness of the PRHPP was found to be associated with increased understanding of the antibiotic (p = 0.028) and injection prescribing indictors (p = 0.030). However, no significant differences in perceived value and use of the information (p &gt; 0.097) were found between those who were aware and those who were unaware of the PRHPP.Conclusion: Although PRHPP may improve patient understanding of the prescribing performance indicators, its impacts on patient choices are limited due to low levels of perceived value and use of information from patients. Additional support is needed to enable patients to make informed choices using the PRHPP.
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis
Authors: Salvador Elena , Mazzi Cristina , De Santis Nicoletta , Bertoli Giulia , Jonjić Antonija , Coklo Miran , Majdan Marek , Peñalvo José L. , Buonfrate Dora 
Published: October 2023

Background: Effective domiciliary treatment can be useful in the early phase of COVID-19 to limit disease progression, and pressure on hospitals. There are discrepant data on the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim of this study is to evaluate whether the clinical outcome of patients who were hospitalized for COVID-19 is influenced by domiciliary treatment with NSAIDs. Secondary objective was to explore the association between other patient characteristics/therapies and outcome.Methods: A large dataset of COVID-19 patients was created in the context of a European Union-funded project (unCoVer). The primary outcome was explored using a study level random effects meta-analysis for binary (multivariate logistic regression models) outcomes adjusted for selected factors, including demographics and other comorbidities.Results: 218 out of 1,144 patients reported use of NSAIDs before admission. No association between NSAIDs use and clinical outcome was found (unadj. OR: 0.96, 95%CI: 0.68-1.38). The model showed an independent upward risk of death with increasing age (OR 1.06; 95% CI 1.05-1.07) and male sex (1.36; 95% CI 1.04-1.76).Conclusion: In our study, the domiciliary use of NSAIDs did not show association with clinical outcome in patients hospitalized with COVID-19. Older ages and male sex were associated to an increased risk of death.
Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift
Authors: Plotkin Daniel L. , Rodas Merlina A. , Vigotsky Andrew D. , McIntosh Mason C. , Breeze Emma , Ubrik Rachel , Robitzsch Cole , Agyin-Birikorang Anthony , Mattingly Madison L. , Michel J. Max , Kontos Nicholas J. , Lennon Sarah , Frugé Andrew D. , Wilburn Christopher M. , Weimar Wendi H. , Bashir Adil , Beyers Ronald J. , Henselmans Menno , Contreras Bret M. , Roberts Michael D. 
Published: October 2023

We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Untrained college-aged participants were randomized into HT (n = 18) or SQ (n = 16) groups. Surface electromyograms (sEMG) from the right gluteus maximus and medius muscles were obtained during the first training session. Participants completed 9 weeks of supervised training (15–17 sessions), before and after which gluteus and leg muscle cross-sectional area (mCSA) was assessed via magnetic resonance imaging. Strength was also assessed prior to and after the training intervention via three-repetition maximum (3RM) testing and an isometric wall push test. Gluteus mCSA increases were similar across both groups. Specifically, estimates [(−) favors HT (+) favors SQ] modestly favored the HT versus SQ for lower [effect ±SE, −1.6 ± 2.1 cm2; CI95% (−6.1, 2.0)], mid [−0.5 ± 1.7 cm2; CI95% (−4.0, 2.6)], and upper [−0.5 ± 2.6 cm2; CI95% (−5.8, 4.1)] gluteal mCSAs but with appreciable variance. Gluteus medius + minimus [−1.8 ± 1.5 cm2; CI95% (−4.6, 1.4)] and hamstrings [0.1 ± 0.6 cm2; CI95% (−0.9, 1.4)] mCSA demonstrated little to no growth with small differences between groups. mCSA changes were greater in SQ for the quadriceps [3.6 ± 1.5 cm2; CI95% (0.7, 6.4)] and adductors [2.5 ± 0.7 cm2; CI95% (1.2, 3.9)]. Squat 3RM increases favored SQ [14 ± 2 kg; CI95% (9, 18),] and hip thrust 3RM favored HT [−26 ± 5 kg; CI95% (−34, −16)]. 3RM deadlift [0 ± 2 kg; CI95% (−4, 3)] and wall push strength [−7 ± 12N; CI95% (−32, 17)] similarly improved. All measured gluteal sites showed greater mean sEMG amplitudes during the first bout hip thrust versus squat set, but this did not consistently predict gluteal hypertrophy outcomes. Squat and hip thrust training elicited similar gluteal hypertrophy, greater thigh hypertrophy in SQ, strength increases that favored exercise allocation, and similar deadlift and wall push strength increases.
Antenatal depression and associated factors among pregnant women attending antenatal care at public health facilities in the Gida Ayana district, Oromia Region, West Ethiopia, in 2022
Authors: Oljira Lelisa , Abdissa Eba , Lema Matiyos , Merdassa Emiru , Wakoya Feyisa Jira , Desalegn Markos 
Published: October 2023

BackgroundThough antenatal depression (AND) has a risk of maternal and fetal morbidity and mortality, it is a neglected component of pregnancy care in Ethiopia. Research evidence is compulsory in different parts of the country to alleviate this problem. Thus, this study was needed to assess antenatal depression and its associated factors, which can help antenatal care (ANC) providers and program coordinators focus on the mental health of pregnant mothers.ObjectivesThis study aimed to assess antenatal depression and associated factors among pregnant women attending ANC at public health facilities in the Gida Ayana district, Oromia Region, West Ethiopia, in 2022.MethodsA facility-based cross-sectional study was conducted among 370 pregnant women attending ANC at public health facilities. Systematic random sampling techniques were used to select study participants. A standard (validated) tool, the Edinburgh Postnatal Depression Scale, was also used to assess antenatal depression. The collected data were coded, entered into Epi-data software version 4.6, and analyzed by SPSS version 23. Multivariable logistic regression analyses were used to identify associated factors with a p-value &lt;0.05.ResultsIn this study, the prevalence of antenatal depression was 62 (16.8%; 95% CI: 13, 20.5). Being single in marital status (AOR = 3, 95% CI: 1.5, 6.2), having an unplanned pregnancy (AOR = 2.7, 95% CI: 1.45, 5.1), and having partner conflict (AOR = 3.49, 95% CI: 1.79, 6.8) were the factors associated with antenatal depression.ConclusionAbout one in five pregnant women has antenatal depression. Being single, having an unplanned pregnancy, and having a dissatisfied relationship with a sexual partner were the factors associated with antenatal depression. Therefore, women or partners are expected to plan pregnancy, and the dissemination of health information related to an unplanned pregnancy needs to be intensified by health providers. The partner ought to avoid conflict during the pregnancy, and healthcare providers or families are needed to support the single or widowed pregnant women. Further prospective cohort studies are needed to ascertain the effect of antenatal depression on fetal–maternal outcomes.
Differences of corruption types in selected Western and central-eastern health systems during the COVID-19 pandemic: a rapid review
Authors: Gonzalez-Aquines Alejandro , Cordero-Perez Adolfo C. , Kowalska-Bobko Iwona 
Published: October 2023

ObjectivesTo identify, describe, and classify the cases of health corruption present in selected Western [the Netherlands and the United Kingdom (UK)] and Central-Eastern European (Poland and Slovakia) countries during the COVID-19 pandemic.MethodsA rapid review of the literature was conducted, evaluating data from 11 March 2020 to 15 April 2021. Information sources included MEDLINE via WoS, IBSS via ProQuest, Scopus, and gray literature.ResultsThirteen cases were identified across the four countries. The primary type of health corruption in Western European countries was procurement corruption, while misuse of (high) level positions was the most prevalent in Central-Eastern European countries. Actors from central governments were most involved in cases. The rule of law and anti-corruption watchdogs reported most cases in the United Kingdom and the Netherlands, while the media reported cases in Poland and Slovakia.ConclusionThe differences in types of corruption in WE and CEE countries emphasize the need to contextualize the approach to tackle corruption. Thus, further research in preventing and tackling corruption is a vital and necessary undertaking despite the inherent of conducting health corruption research.
Use of hardwood mulch applications to improve soil characteristics of Alfisols used in Florida citrus production
Authors: Hallman Lukas M. , Santiago John M. , Fox John-Paul , Pitino Marco , Shatters Robert G. , Rossi Lorenzo 
Published: October 2023

IntroductionImproving soil fertility is a top priority in Florida’s citrus growing regions, especially in the age of Huanglongbing (HLB; also known as citrus greening). This disease severely reduces fine root mass, causes higher incidences of nutrient deficiencies, and eventually results in the death of affected trees. Additionally, the soils commonly found in Florida’s citrus growing regions are sandy (greater than 98%) and naturally low in fertility, making the nutrient management of HLB-affected trees even more challenging. As a result, interest in organic amendments to increase soil fertility are being tested. Although hardwood chip mulches are successfully used in other regions of the country, no studies exist observing their use on the soils in Florida’s citrus growing regions; therefore, the objectives of this study were to measure the impacts of hardwood oak mulch on (i) Florida Alfisols characteristics and (ii) HLB-affected citrus trees.MethodsA two-treatment field study using 6-year-old ‘Valencia’ sweet orange trees (Citrus × sinensis) grafted on US-812 (C. reticulata × C. trifoliata) rootstock was conducted in Florida’s Indian River District (IRD). The experimental treatment consisted of 0.08 m of hardwood chip mulch sourced from oak trees applied every September for 3 years (2020, 2021, and 2022) while the control treatment had no mulch applied. Soil chemical and physical properties, leaf nutrient concentration, and leaf Candidatus Liberibacter asiaticus (CLas) titer was collected in the fall (October), winter (January), spring (April), and summer (July).Results and discussionOverall, after 3 years, oak mulch applications increased soil available phosphorus (32%), potassium (66%), magnesium (71%), organic matter (49%), and moisture (25-88%, depending on the season); however, oak mulch inconsistently impacted leaf nutrient concentrations and was not effective at suppressing HLB. The results show that annual applications of hardwood oak mulch can improve the chemical and physical properties of sandy soils within three years, however, these improvements did not reduce the severity of HLB.
Relations between specific athleticism and morphology in young basketball players
Authors: Čović Nedim , Čaušević Denis , Alexe Cristina Ioana , Rani Babina , Dulceanu Corina Ramona , Abazović Ensar , Lupu Gabriel Stanica , Alexe Dan Iulian 
Published: October 2023

IntroductionBasketball is a fast-paced intermittent team sport, wherein the players must exhibit different morphologies and fitness levels depending on their position. The aim of this study was to assess the differences in the athleticism of basketball players by playing positions and in its relations with body composition and anthropometric measures. It was hypothesized that calculated athleticism has stronger and better predictive relations with morphology compared to motoric tests alone.Methods47 basketball players were divided into three groups according to playing position [guards (n = 14), forwards (n = 22), centers (n = 11)]. Body composition and anthropometrical measurements were done for all players. Athleticism was presented in terms of overall (OFS), jumping (JFS) and sprinting (SFS) fitness scores.ResultsFitness scores were found to be more strongly related to body composition and anthropometry measurements than motoric tests alone. All three fitness scores were moderate to strongly correlated with skinfold thickness and fat percentage, while body height, fat-free mass, and lean body mass were positively correlated. Significant differences in athleticism fitness scores were found between guards and other groups. Forwards displayed superior athleticism in power and sprint abilities when compared to guards and centers. Multivariate logistic regression revealed that fat percentage, lean muscle mass, skinfold thickness, and arm span exhibited strong predictive capabilities in relation to athleticism scores.ConclusionsCoaches and practitioners should be aware that athleticism includes a multitude of components, and they should use athleticism assessments before designing training regimens that are tailored to each position's unique needs.