bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local site effects and seismic microzonation around Suban Area, Curup Rejang Lebong, Bengkulu deduced by ambient noise measurements
Authors: Siburian Brecya Isa , Marzuki Marzuki , Lubis Ashar Muda 
Published: January 2024

Abstract
Background
The Suban area of Curup Rejang Lebong is a tourist region in Bengkulu Province, Indonesia, close to the active Ketaun and Musi faults, which are segments of the Sumatra Fault System (SFS). However, no studies have been conducted in this area to assess how geological structures affect seismic ground motions and contribute to seismic hazard and risk assessment.

Methods
The first study of seismic microzonation in the Suban area of Curup City by ambient noise measurements was conducted at 100 sites, spaced ~ 1 km apart, with 60 min of data acquisition for each site. All microseismic data were processed using the Horizontal to Vertical Spectral Ratios (HVSR) method.

Results
The HVSR method revealed the amplification factors (A0) ranging from 1.23 to 8.26 times, corresponding to natural frequency (f0) variations between 1.24 and 9.67 Hz. About 13% and 55% of the sites show high (6 ≤ A0 ≤ 9) and medium (3 ≤ A0 ≤ 6) amplifications, respectively, predominantly in the western parts of the study area, consistent with a high seismic vulnerability index (Kg). Furthermore, we also estimated the ground shear strain (GSS) of the region using the Kanai method with two large historical earthquakes at the Ketahun segment in 1943 (Mw 7.4) and the Musi segment in 1979 (Mw 6.0). The Kg value is consistent with the GSS values and indicates areas of severe damage during the historic earthquakes.

Conclusions
Thus, the western parts of the Suban region are vulnerable to severe damage from an earthquake. These findings could provide valuable insights for future planning and risk management efforts aimed at minimizing the impact of earthquakes in the Suban region.
Treatment of glucocorticoid- induced hyperglycemia in hospitalized patients - a systematic review and meta- analysis
Authors: Struja Tristan , Nitritz Neele , Alexander Islay , Kupferschmid Kevin , Hafner Jason F. , Spagnuolo Carlos C. , Schuetz Philipp , Mueller Beat , Blum Claudine A. 
Published: January 2024

Abstract
Purpose
Glucocorticoid (GC)-induced hyperglycemia is a frequent issue, however there are no specific guidelines for this diabetes subtype. Although treat-to-target insulin is recommended in general to correct hyperglycemia, it remains unclear which treatment strategy has a positive effect on outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess whether treating GC-induced hyperglycemia improves clinical outcomes.

Methods
MEDLINE and EMBASE were systematically searched for RCTs on adults reporting treatment and outcomes of GC-induced hyperglycemia since the beginning of the data bases until October 21, 2023. Glucose-lowering strategies as compared to usual care were investigated.

Results
We found 17 RCTs with 808 patients and included seven trials in the quantitative analysis. Patients with an intensive glucose-lowering strategy had lower standardized mean glucose levels of – 0.29 mmol/l (95%CI -0.64 to -0.05) compared to usual care group patients. There was no increase in hypoglycemic events in the intensively treated groups (RR 0.91, 95%CI 0.70–1.17). Overall, we did not have enough trials reporting clinical outcomes for a quantitative analysis with only one trial reporting mortality.

Conclusion
In GC-induced hyperglycemia, tight glucose control has a moderate effect on mean glucose levels with no apparent harmful effect regarding hypoglycemia. There is insufficient data whether insulin treatment improves clinical outcomes, and data on non-insulin based treatment regimens are currently too sparse to draw any conclusions.

Systematic review registration
Registered as CRD42020147409 at PROSPERO (https://www.crd.york.ac.uk/prospero/) on April 28, 2020
The implication of cryptocurrency volatility on five largest African financial system stability
Authors: Joseph Tonuchi E. , Jahanger Atif , Onwe Joshua Chukwuma , Balsalobre-Lorente Daniel 
Published: January 2024

AbstractThis study examined the interconnectedness and volatility correlation between cryptocurrency and traditional financial markets in the five largest African countries, addressing concerns about potential spillover effects, especially the high volatility and lack of regulation in the cryptocurrency market. The study employed both diagonal BEKK-GARCH and DCC-GARCH to analyze the existence of spillover effects and correlation between both markets. A daily time series dataset from January 1, 2017, to December 31, 2021, was employed to analyze the contagion effect. Our findings reveal a significant spillover effect from cryptocurrency to the African traditional financial market; however, the percentage spillover effect is still low but growing. Specifically, evidence is insufficient to suggest a spillover effect from cryptocurrency to Egypt and Morocco’s financial markets, at least in the short run. Evidence in South Africa, Nigeria, and Kenya indicates a moderate but growing spillover effect from cryptocurrency to the financial market. Similarly, we found no evidence of a spillover effect from the African financial market to the cryptocurrency market. The conditional correlation result from the DCC-GARCH revealed a positive low to moderate correlation between cryptocurrency volatility and the African financial market. Specifically, the DCC-GARCH revealed a greater integration in both markets, especially in the long run. The findings have policy implications for financial regulators concerning the dynamics of both markets and for investors interested in portfolio diversification within the two markets.
Researcher and patient experiences of co-presenting research to people living with systemic sclerosis at a patient conference: content analysis of interviews
Authors: Wurz Amanda , Ellis Kelsey , Nordlund Julia , Carrier Marie-Eve , Cook Vanessa , Gietzen Amy , Adams Claire , Nassar Elsa-Lynn , Rice Danielle B. , Fortune Catherine , Guillot Genevieve , Mieszczak Tracy , Richard Michelle , Sauve Maureen , Thombs Brett D. 
Published: January 2024

Abstract
Background
Patient engagement in research is important to ensure research questions address problems important to patients, that research is designed in a way that can effectively answer those questions, and that findings are applicable, relevant, and credible. Yet, patients are rarely involved in the dissemination stage of research. This study explored one way to engage patients in dissemination, through co-presenting research.

Methods
Semi-structured, one-on-one, audio-recorded interviews were conducted with researchers and patients who co-presented research at one patient conference (the 2022 Canadian National Scleroderma Conference) in Canada. A pragmatic orientation was adopted, and following verbatim transcription, data were analyzed using conventional content analysis.

Results
Of 8 researchers who were paired with 7 patients, 5 researchers (mean age = 28 years, SD = 3.6 years) and 5 patients (mean age = 45 years, SD = 14.2 years) participated. Researcher and patient perspectives about their experiences co-presenting and how to improve the experience were captured across 4 main categories: (1) Reasons for accepting the invitation to co-present; (2) Degree that co-presenting expectations were met; (3) The process of co-presenting; and (4) Lessons learned: recommendations for co-presenting.

Conclusions
Findings from this study suggest that the co-presenting experience was a rewarding and enjoyable way to tailor research dissemination to patients. We identified a patient-centred approach and meaningful and prolonged patient engagement as essential elements underlying co-presenting success.
A human rights-based approach for effective criminal justice response to human trafficking
Authors: Demeke Saba 
Published: January 2024

AbstractHuman trafficking is a complex, multifaceted, and deeply layered issue. Consequently, any mitigation strategy employed against it must also be layered and target the distinct aspects of the issue. For long, the obvious and perhaps the most visible practice to deal with cases of trafficking has been employing a criminal justice approach where the focus largely lies on the persecution of the criminal instead of the protection of the survivors. More nuanced approaches, such as anti-trafficking clauses that protect human rights and focus on removing root causes that directly or indirectly have an impact on trafficking patterns, including labor, migration, and sexual exploitation issues, have emerged to successfully tackle human trafficking as a global issue. The principles and guidelines for such a multi-sectoral, human rights-based approach are primarily aimed at trafficking prevention, protection, assistance to survivors of trafficking, criminalization, punishment, and redressal. This article aims to evaluate this approach and its intersections with the traditional criminal justice approach. It will further discuss the approach that is currently in practice and argue for further improvements and efforts. Finally, it will also discuss the impact of COVID-19 on trafficking in persons.
Safety and feasibility study of a novel robotic system in an in vivo porcine vascular model
Authors: Moschovaki-Zeiger Ornella , Arkoudis Nikolaos-Achilleas , Spiliopoulos Stavros 
Published: January 2024

AbstractPurposeThe goal of this preclinical study is to assess the functionality, technical feasibility, and safety of a new vascular robotic LIBERTYR3 System, in the microcatheterization of vascular targets using a range of guidewires and microcatheters.Material and methodsAn anesthetized pig served as an arterial model for the robotic device (LIBERTYR3; Microbot Medical Ltd, Yoqneam, IL). The primary efficacy endpoint was the evaluation of its capability to selectively catheterize predetermined distal arterial branches in the liver, kidneys, and mesenteric arteries (technical success), under fluoroscopy guidance. The primary safety endpoint was the occurrence of angiographic acute catheterization-related complications (dissection, thrombosis, embolism, perforation). The catheterizations were conducted by two interventional radiologists that present different work experience in endovascular procedures (18 and 2 years respectively), using a variety of microcatheters and wires. Various procedural parameters such as functionality, practicality, ease of use, and time required for selective catheterization, were evaluated, and recorded.ResultsAll pre-determined arteries were successfully selectively catheterized (100% technical success), by both operators. No angiographic acute complications occurred. The microcatheters and wires were manipulated using the remote portable console in an effortless manner that maintained a high level of accuracy. Mean time for selective catheterization was 131 ± 82 s. The robot's conversion function to manual operation was successfully demonstrated.ConclusionRobotic navigation and catheterization of selected target arteries were accomplished without observable vascular damage, suggesting that the LIBERTYR3 robotic system is a reliable and safe tool for robotic-assisted endovascular navigation. Further experimental studies are required to evaluate safety and efficacy prior to introduction into clinical practice.
Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context
Authors: Saddam Md. , Paul Shamrat Kumar , Habib Mohammad Ahsan , Fahim Md. Abrar , Mimi Afsana , Islam Saiful , Paul Bristi , Helal Md Mostofa Uddin 
Published: January 2024

AbstractApoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis-inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning, and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, multiple sclerosis, diabetes. In this review, we addressed the genetic information and structural homology of BCL-2 family members. Further, we elucidate the pro-apoptotic and anti-apoptotic roles of the family members. This review highlights the most recent developments in the BCL-2 protein family and presents evidence that targeting this family proteins may have a positive impact on the treatment of medical problems that are still underserved.
A case report of left circumflex stent infection and mycotic aneurysm: a rare but life-threatening complication of percutaneous coronary intervention
Authors: Kumar Swasthi S. , Suresh Sumanyu , Iliyas Mohamed , Vijay Jyothi , Pillai Vivek 
Published: January 2024

Abstract
Background
Coronary stent infections are an uncommon but deadly complication of percutaneous coronary intervention. Mortality remains as high as 40–60% even with adequate treatment. We report such an interesting case of left circumflex stent (LCX) infection and mycotic aneurysm that was successfully managed with antibiotics and surgery.

Case presentation
A middle-aged man who underwent percutaneous coronary intervention (PCI) to the left circumflex artery four weeks prior was referred as a case of pyrexia of unknown origin, not responding to antibiotics, and colchicine started for suspected Dressler syndrome. Although the inflammatory markers were elevated, the results of the blood culture did not show any growth. Echocardiography showed a doubtful echogenic structure in the left atrioventricular groove and mild pericardial effusion, and a stent infection was suspected. PET scan showed focal metabolic activity in the region of the LCX stent, with metabolically active supraclavicular and paratracheal lymph nodes, and a coronary angiogram revealed an aneurysm arising distal to the stented LCX. A diagnosis of stent infection and associated mycotic aneurysm was made, and the patient underwent surgery which included aneurysm repair, stent retrieval, and coronary artery bypass graft (CABG) to the major and terminal OM. The postoperative course was uneventful, and the patient was discharged without complications.

Conclusions
It is important to investigate the possibility of coronary stent infection in individuals experiencing prolonged fever following PCI. PET scans and coronary angiograms can aid in diagnosis when echocardiograms are inconclusive. Adequate antibiotic therapy and timely surgery are crucial for successfully managing coronary stent infections.
Examining the relationship of career crafting, perceived employability, and subjective career success: the moderating role of job autonomy
Authors: Diaa Naglaa Mohamed , Abidin Ali Zain Ul , Roller Marvin 
Published: January 2024

AbstractCareer crafting has emerged as a significant construct in the field of career development, with the potential to significantly boost individuals’ overall work satisfaction. This study aimed to examine whether career crafting could improve individual’s subjective career success and perceived employability. Career crafting is an inevitable course of career-related actions to achieve career satisfaction. Based on proactive behavior theory, it is hypothesized that career crafting would have an impact on individuals’ subjective career success and perceived employability through the moderating role of job autonomy. Using cross-sectional study design, data were collected via Google Forms survey from 224 employees working in various fields in Pakistan and data were analyzed using structural equation modeling (SEM) via AMOS. The results indicate that career crafting has a significant positive relationship with subjective career success and perceived employability. Furthermore, job autonomy also has significant positive relationship with subjective career success and perceived employability. However, the moderation of job autonomy was not supported. This study provides robust insights to career practitioners, academicians, and individuals. Overall, the study expands the literature of the novel notion of career crafting and career outcomes; additionally, the study advocates organizations to include career crafting in HR policies and helping them to enhance the well-being of employees in their career development.
Robust joint adaptive multiparameter waveform inversion with attenuation compensation in viscoacoustic media
Authors: Li Chao , Liu Guochang , Li Fang , Wang Zhiyong 
Published: January 2024

Full-waveform inversion (FWI) has been proven as an effective method to estimate subsurface parameters by iteratively reducing the data residual between the predictions and the observations. Nevertheless, FWI is greatly dependent on the initial model, and a poor initial model will lead to an incorrect solution. Furthermore, owing to the anelasticity of the earth, seismic waves will attenuate during propagation, which results in an attenuated gradient and makes the convergence rate of FWI even worse in viscoacoustic medium. Commonly, multiparameter (e.g. velocity and Q) waveform inversion can be used to mitigate these problems. Benefiting from the theory of Q-compensated wavefield propagation, we develop a Q-compensated joint multiparameter waveform inversion method to weaken the nonlinearity of the FWI objective function, which enables it to cope with challenges related with attenuation-induced gradient energy loss and cycle skipping simultaneously. We refer to our Q-compensated joint multiparameter FWI scheme as QJMFWI. The main contributions of QJMFWI are as follows: (1) given the difficulty associated with the estimation of velocity and Q simultaneously in viscoacoustic media, QJMFWI provides a straightforward waveform inversion method for velocity and Q model construction, by which we can obtain velocity and Q information with improved accuracy and resolution; and (2) compared with conventional FWI methods, QJMFWI relaxes the requirement for a good initial velocity and Q model, which can avoid trapping into local minima. Numerical and field data examples demonstrate that QJMFWI is an effective method to invert for accurate subsurface parameters in viscoacoustic media.
Remission of Ectopic Cushing Syndrome Secondary to Medullary Thyroid Cancer With Vandetanib and Selpercatinib
Authors: Jazdarehee Aria , Abdel-Rahman Omar , Jacquier Jennifer E 
Published: January 2024

Abstract
Medullary thyroid cancer (MTC) is a neuroendocrine tumor associated with activating mutations of the rearranged during transfection (RET) proto-oncogene. These tumors may rarely secrete adrenocorticotropin or corticotropin-releasing hormone, resulting in a paraneoplastic ectopic Cushing syndrome (ECS). Paraneoplastic ECS carries a high risk of mortality, and management is difficult due to the lack of response to antiadrenal therapies. We report on a 37-year-old man who was diagnosed with metastatic MTC and reported symptoms of cortisol excess with laboratory testing in keeping with ECS. He began treatment with vandetanib, a multitargeted tyrosine kinase inhibitor, which resulted in decreased tumor burden as well as clinical and biochemical resolution of ECS. Due to progressive structural disease 10 months later, he was switched to the selective RET inhibitor selpercatinib, which was followed by a rapid reduction of cortisol nearing the threshold of adrenal insufficiency. Tumor markers were also improved, and repeat imaging showed decreased tumor burden. Our case highlights the efficacy of tyrosine kinase inhibitors in the management of paraneoplastic ECS. Selective RET inhibitors may emerge as preferred targeted treatment options due to better efficacy and toxicity profiles compared to multitargeted inhibitors. Clinicians should monitor for adrenal insufficiency with the use of selective RET inhibitors.
A Case of an Ectopic ACTH-Producing Tumor With Adrenal Shrinkage During Osilodrostat Administration
Authors: Sawabe Fumikazu , Hayafusa Ryo , Kosugi Rieko , Ariyasu Hiroyuki 
Published: January 2024

Abstract
Ectopic adrenocorticotropin (ACTH)-secreting tumors are among the causes of ACTH-dependent Cushing syndrome. When surgical resection of the primary lesion is not feasible, medications such as metyrapone, mitotane, and ketoconazole have been used to control hypercortisolism. This report presents a case treated with the novel drug osilodrostat, wherein the patient's adrenal glands exhibited shrinkage following the initiation of this drug. The case involves a 68-year-old man diagnosed with small cell lung cancer and ectopic ACTH-producing Cushing syndrome. Initially, metyrapone was administered to manage hypercortisolism, but its effect proved insufficient. Subsequently, osilodrostat was initiated while gradually decreasing metyrapone, leading to full suppression of blood cortisol levels. With continued osilodrostat treatment, the adrenal glands reduced in size, suggesting the potential to reduce the osilodrostat dosage.
Understanding of Eosinophilic Esophagitis in Children - A Comprehensive Study on Epidemiology, Clinical Manifestations, Diagnosis and Innovative Treatment Modalities
Authors: Zarzycka Marta , Sikora Marcelina , Plewniok Ines , Maj-Dziedzic Monika , Dubiel Jeremiasz , Brzozowska Anna , Maj Adrian , Śmietana Greta , Warno Martyna , Kozik Wiktor 
Published: January 2024

Introduction:
In the late 1960s, probable cases of eosinophilic esophagitis (EoE) emerged, initially linked to esophageal rings and congenital causes or gastroesophageal reflux disease (GERD). Doubts about the GERD association arose due to poor responses to antisecretory therapy. EoE is now a significant pediatric health concern, impacting 1 to 7 cases per 10,000 children.
Purpose of the Study:
This study aims to comprehensively explore EoE's epidemiology, etiology, subtypes, clinical manifestations, diagnostic methods, and treatment modalities.
Materials and Methods:
The study employs a cross-sectional analysis of pediatric EoE patients, utilizing endoscopic evaluation and histological assessment. Three distinct EoE subtypes are identified based on pathogenic characteristics. Clinical manifestations, diagnostic methods, and treatments, including endoscopy, are examined.
Results:
Clinical manifestations span a broad spectrum in the pediatric population. Diagnostic methods include endoscopy, esophageal manometry, impedance-pH monitoring, capsule endoscopy, and string tests. Three distinct EoE subtypes are identified with unique characteristics. Treatment modalities involve dietary management, proton pump inhibitors, topical corticosteroids, biologic therapies, allergen immunotherapy, and endoscopic interventions.
Conclusion:
Formerly associated with GERD, EoE is now a significant pediatric health concern. The study underscores the importance of comprehensive diagnostic approaches and diverse treatment modalities, including promising biologic therapies and allergen immunotherapy. Understanding these aspects is crucial for effective management and improved outcomes in patients.