bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and mental health in China: the effects of personality
Authors: Zhang Xiao , Battisti Michele , Proto Eugenio 
Published: December 2023

BackgroundChina was the first country affected by the COVID-19 virus, and it is a very important case to study the effects of the virus and the consequent restrictions. However, national representative studies of how the COVID-19 pandemic affects mental health in China are still limited.MethodsUsing two waves of the China Family Panel Studies, we follow the same individuals before and during the pandemic. We compare weighted means using 95% CIs to explore mental health deterioration, and we and perform several linear regressions with the Ordinaly Least Square (OLS) estimator to identify individuals most affected by the COVID-19 pandemic.ResultsThe prevalence of severe cases of depression, measured using an eight-item version of the common Centre for Epidemiologic Studies Depression Scale (CES-D), increased from 6.68% in 2018 to 7.86% in 2020; quantifiable as around a 18% increase. This deterioration is higher for individuals subject to strict lockdowns, about 0.4 symptoms more on average, and it is stronger among those who already reported symptoms of depression in the 2018 wave of data. Individuals with more open personalities tend to experience more severe deterioration: a 1 SD change in the openness trait corresponds to 0.05 more symptoms. On the other hand, more neurotic individuals seem less negatively affected.ConclusionWe find clear evidence of a moderate level of mental health deterioration between 2018 and 2020. These effects are larger for individuals subject to stricter lockdowns and for individuals with more open personalities.
Canadian patient experiences of lupus nephritis: a qualitative analysis
Authors: Cardwell Francesca S , Elliott Susan J , Barber Megan R W , Cheema Kim , George Sydney , Boucher Adrian , Clarke Ann Elaine 
Published: December 2023

ObjectiveLupus nephritis (LN) is one of the most severe manifestations of SLE; however, we know little about the lived experience of LN. This research investigates patient experiences and perspectives of (1) LN diagnosis; (2) living with LN; and (3) LN healthcare and treatment.MethodsPatients aged ≥18 years with biopsy-proven pure or mixed International Society of Nephrology/Renal Pathology Society class III, IV or V LN were purposefully recruited from a Canadian lupus cohort to participate in semistructured in-depth interviews.ResultsThirty patients with LN completed the interviews. The mean (SD) age was 42.1 (16.4) years, and 86.7% were female. Participants described challenges seeking, receiving and adjusting to a LN diagnosis, and some reported that their diagnosis process took weeks to years. While 16 participants were provided resources by healthcare providers to help them through the process of diagnosis, the need for accessible LN-specific information at diagnosis was highlighted (n=18). Participants also described the unpredictability of living with LN, particularly related to impacts on physical and mental health, relationships, leisure activities, employment and education, and family planning. While most (n=26) participants reported a positive impression of their care, the side effects of LN medications and the need to increase patient and societal awareness/understanding of LN were highlighted in the context of healthcare and treatment.ConclusionsThe unpredictability of living with LN, the heavy treatment burden and a lack of patient/societal awareness substantially affect the lived experience of LN. These findings will inform the development of LN-specific patient resources to increase understanding of LN and improve well-being for patients.
Effects of early exposure to palliative care on end-of-life outcomes in patients with cancer in a community setting
Authors: Fratt Ellie , Haupt Eric C , Wang Susan E , Nguyen Huong 
Published: December 2023

ObjectiveAlthough prior studies show that exposure to early outpatient palliative care (OPC) versus no exposure is associated with improved outcomes at the end of life (EoL) for patients with cancer, few examined the impact of exposure to OPC prior to home-based palliative care (HBPC) on EoL outcomes. This study compares the effect of OPC prior to HBPC versus HBPC alone on EoL outcomes in patients with cancer.MethodsA secondary analysis of data from a trial comparing two models of HBPC was performed on patients with primary cancer diagnoses. Adjusted negative binomial and logistic regression models were used to compare days in acute care and intensive care unit stays in the last 30 days, chemotherapy administration in the last 14 days and in-hospital deaths between patients who received standard-dose (4+ encounters) and low-dose (<4 encounters) OPC plus HBPC versus HBPC alone.ResultsA total of 1187 patients, 483 (40.1%) of whom had OPC+HBPC and 704 (59.3%) who had HBPC alone were included in the analyses. Compared with patients who had HBPC alone, patients who had standard-dose OPC spent fewer days in acute care (4.29 vs 4.19, p=0.04) and fewer days inpatient (3.45 vs 3.09, p=0.03) in the last 30 days of life. No difference was seen in EoL outcomes in patients exposed to low-dose OPC compared with those with HBPC alone. Receipt of hospice after HBPC was strongly associated with improved EoL outcomes.ConclusionFuture research is needed to examine the modality, timing and intensity of palliative care necessary to effect EoL outcomes.
Cyclotron-based production of innovative medical radionuclides at the INFN-LNL: state of the art and perspective
Authors: Pupillo Gaia , Andrighetto Alberto , Arzenton Alberto , Ballan Michele , Bello Michele , Boschi Alessandra , Cisternino Sara , Corradetti Stefano , De Dominicis Lucia , Esposito Juan , Fioretto Enrico , Ghirardi Teresa , Manzolaro Mattia , Mariotti Emilio , Martini Petra , Melendez-Alafort Laura , Monetti Alberto , Mou Liliana , Scarpa Daniele , Sciacca Gabriele , Serafini Davide 
Published: December 2023

AbstractThe production of medical radionuclides is one of the research activities carried out in the framework of the SPES (Selective Production of Exotic Species) project under the completion stage at the Legnaro National Laboratories of the National Institute for Nuclear Physics (INFN-LNL). The heart of SPES is the 70-MeV proton cyclotron having a dual-beam extraction, installed and commissioned in a new building equipped with ancillary laboratories currently under construction. The SPES main goal is the realization of an advanced ISOL (Isotope Separation On-Line) facility to produce re-accelerated exotic ion beams for fundamental nuclear physics studies. The cyclotron double-beam extraction system allows to simultaneously carry out applied research, such as radionuclides production for medicine (SPES-$$\gamma$$
γ
). This paper summarizes the results obtained with the interdisciplinary projects LARAMED (LAboratory of RAdionuclides for MEDicine) and ISOLPHARM (ISOL technique for radioPHARMaceuticals). The first one, based upon the direct activation method, is focused on the production of the radionuclides under the spotlight of the international community (e.g., $$^{99m}$$

99
m

Tc, $$^{67}$$

67

Cu, $$^{52/51}$$

52
/
51

Mn, $$^{47}$$

47

Sc and Tb isotopes), from the nuclear cross-section measurements up to the preclinical studies. The other one exploits the ISOL technique for the development and production of radioisotopes with high-specific activity, such as $$^{111}$$

111

Ag, going beyond the state of the art in the field. The most recent SPES-$$\gamma$$
γ
research activities and future perspective are here described, characterized by a consolidated network of collaborations with national and international institutions.
Wrestling with the Diaspora’s Angels: A Note on Fra Angelico’s Legacy in Hungarian-Israeli Art
Authors: Farkas Mariann 
Published: December 2023

Abstract
While numerous scholars have analyzed the influence of immigration on Jewish visual culture, few have focused on the Hungarian-Israeli scene. This article seeks to resolve some of the lacunae surrounding expressions of Hungarian immigrant experiences in Israeli art by analyzing the Annunciation theme in Hedi Tarjan’s series Homage to Fra Angelico, which was painted in the 1980s and the 2000s. A woman artist with a complex Christian-Jewish identity, Tarjan expressed her cross-cultural and interfaith experiences in her paintings and can be regarded as a “Jewish Diasporist” in the sense elaborated in American artist R. B. Kitaj’s manifestos. The article concludes by arguing that Tarjan, as a Jewish artist who emigrated from Hungary to Israel, faced unique professional, cultural, and religious challenges.
Transfer of Climate Litigation to Biodiversity Protection?
Authors: Glinski Carola 
Published: December 2023

Abstract
In recent years, constitutional courts and supreme courts have handed down important decisions on (potentially) insufficient climate protection regulation. This article analyses the climate decision of the German Federal Constitutional Court and discusses its application to biodiversity protection. It shows that despite of clarifications related to the State’s constitutional duty to protect citizens, including future generations, against the risks of climate change, the application of the decision to other urgent environmental problems remains unclear. The German standard of review grants the legislator considerable leeway in case of remaining scientific uncertainty and still relies on a clear quantification of protection needs. In contrast, the Urgenda ruling of the Dutch Supreme Court shows the way how in case of scientific uncertainty (potentially insufficient) environmental protection can be judicially reviewed while safeguarding the margin of appreciation of the legislator at the same time.
Sacred Time and Religious Violence: Evidence from Hindu-Muslim Riots in India
Authors: Allie Feyaad 
Published: December 2023

How and when can religious times become focal points for communal violence? In the context of Hindu-Muslim riots in India, I argue that incompatible ritual holidays where one religion’s rituals are at odds with another (e.g., sacrificing cows or engaging in processions with idolatry) help explain the positive effect of sacred time on religious rioting. Holidays with incompatible rituals provide doctrinal differences that make riots more likely. These types of holidays can be used by riot entrepreneurs to incite violence or can independently raise an individual’s willingness to engage in violence. I provide support for this argument by analyzing data on Hindu-Muslim riots across 100 years. I investigate the mechanisms through additional analysis and examining historical and present-day cases of riots that occurred on holidays. By focusing on the content of religion, this paper demonstrates how particular religious holidays can provide the underlying conditions that elites use to incite religious violence.
Up Schitt’s Creek? Comedy as a Slantwise Pedagogical Encounter with Queerness
Authors: Henry Seán , Bryan Audrey , Neary Aoife 
Published: December 2023

Background: Pedagogical approaches to learning about LGBTQI+ themes and experiences remain a largely understudied topic in teacher education. This is partly due to anxieties around exploring these themes in nuanced and sensitive ways, with many teacher educators feeling ill-equipped to navigate the complexities of exploring so-called “difficult knowledge.” Purpose: In response to this, the purpose of this paper is to offer reflections on the pedagogical value of comedy for exploring such themes and experiences in teacher education, focusing especially on the situational comedy (sitcom) Schitt’s Creek. We turn to comedy given our interest in the capacity of comedic modalities to offer “slantwise” pedagogical encounters with LGBTQI+ themes and experiences, that is, nonaffronting encounters that resist damage-centered narratives of LGBTQI+ people and are open to multiple queer futures. Research design: In exploring how the sitcom offers teacher educators and student teachers these kinds of encounters, we provide a reading of three episodes of Schitt’s Creek through a “queer utopian” lens. We analyze a purposive sample of episodes from the series that speak directly to LGBTQI+ themes and experiences. We accompany this analysis with prompts for teacher educators to use in discussing these episodes in the teacher education classroom. Conclusions: We suggest that the sitcom offers teacher education an opportunity for student teachers and teacher educators to access a queer utopianism that can be encountered not only in the specifics of Schitt’s Creek’s plotlines, characters, and/or settings, but also, perhaps more primarily, through the affective dimensions of watching the sitcom itself. The piece comes to a close with some thoughts on the significance of comedy for exploring the relationship among affect, education, and social justice more generally.
Experiences of Students with Learning Disabilities in Higher Education: A Scoping Review
Authors: Kuriakose Alen , Amaresha Anekal C 
Published: December 2023

Background: As the number of students with learning disabilities (SwLD) entering higher education (HE) increases, a need arises to improve the services provided to them by understanding their experiences. This scoping review explores the extent and type of evidence on the experiences of SwLD in HE. Method: The review followed the six stages outlined by Arksey and O’Malley. PubMed, Science Direct, EBSCO, ProQuest, and APA PsycNet were searched for primary data, and studies published between January 2012 and July 2022 were included. The following information was extracted and collated from the included studies: author/s, year, location, objective/aim, study design, materials and methods, and major findings. Results: The search yielded 3729 titles and abstracts. Their screening resulted in 26 eligible articles. The review of these articles identified three major themes: (a) academic concerns, (b) psychosocial experiences, and (c) support systems and accommodations. The academic concerns included difficulties in areas such as reading, writing, and spelling. The studies on psychosocial experiences showed that SwLD experience stress, anxiety, and lower self-esteem. The studies on support systems and accommodations indicate that they get academic support, technological support, and extra time for examinations from educational institutions. Conclusion: The SwLD experiences academic and psychosocial challenges during higher studies. However, the existing support systems do not address these challenges, and there is a need for further research in this area.
Surgical coronary angioplasty of both coronary ostia after chest radiotherapy. Is it good alternative to conventional coronary bypass surgery?
Authors: Mamedov Arslan , Rumbinaitė Eglė , Karčiauskas Dainius , Jakuškaitė Gabrielė , Veikutienė Audronė , Jakuška Povilas , Benetis Rimantas 
Published: December 2023

Introduction Isolated coronary ostial stenosis of both ostia is a rare, potentially life-threatening condition, occurring in 0.1%–0.2% of patients undergoing coronary angiography. Case report We present a case of a 69-year-old woman with a past medical history of breast cancer, who had been treated with radiotherapy, which most likely caused significant stenosis of both coronary ostia and likely accelerated aortic stenosis. Surgical angioplasty with autopericardium patch reconstruction of the left main coronary artery and right coronary arteries due to proximal stenotic disease was performed instead of venous or arterial bypasses with concomitant aortic valve replacement. The postoperative course was uneventful. There were no cardiovascular events 5 years after operation, and the patient remained free of any symptoms. Conclusions Surgical coronary angioplasty offers an alternative to conventional coronary artery bypass grafting in isolated coronary ostial lesions and is advantageous in restoring more physiological myocardial perfusion, especially in those cases when conduits are suspected to be fibrotic, scarred or stenosed after radiation therapy or if there is the need to preserve conduits for future myocardial revascularisation in young patients.
Impact of first eye cataract surgery on falls among patients of advanced age: a comparative study
Authors: Akbari-Kamrani Marjan , Heidarzadeh Hamidreza , Naderan Morteza , Gordiz Arzhang , Hemmati Sara , Chaibakhsh Samira , Mohammadi S. Saeed , Farsani Mohsen Khosravi , Zand Amin , Abdi Fatemeh 
Published: December 2023

Objective To compare the incidence of falls between patients with visually significant cataracts in both eyes and those who have undergone first-eye cataract surgery. Methods This retrospective case–control study involved patients with a history of cataracts in both eyes who had undergone first-eye cataract surgery within the past 9 to 12 months (pseudophakic group). The control group comprised patients with cataracts in both eyes (cataract group). We assessed best-corrected visual acuity (BCVA), systemic comorbidities and medications (using the Charlson comorbidity index), and independent daily activities (using the Lawton Instrumental Activities of Daily Living scale). The patients were questioned about experiencing two or more falls in the last 6 months. Results Each group comprised 50 patients. Binocular BCVA was significantly better in the pseudophakic group (0.05 ± 0.06 logMAR) than in the cataract group (0.77 ± 0.34 logMAR). Of all participants, 22% reported experiencing two or more falls in the last 6 months. Multivariate analysis demonstrated significantly better BCVA in participants with less than two falls. Conclusions Patients of advanced age with visually significant cataracts in both eyes are at a higher risk of falling. First-eye cataract surgery may mitigate the occurrence of falls by improving binocular BCVA.
A Study to Evaluate the Efficacy of Saroglitazar in Non-Alcoholic Steatohepatitis Induced by High Fructose Diet Rat Model
Authors: T. Saravanan , S. Shanmugapriya , Thomas Eliz , P. Karthika 
Published: December 2023

Background Non-alcoholic steatohepatitis (NASH) is a clinical condition with a global prevalence of 25.24%. Peroxisome proliferator-activated receptors (PPAR) have been significantly associated with the pathogenesis of NASH. Aim To evaluate the efficacy of saroglitazar in an animal model of NASH by evaluating the magnitude of changes in liver function tests (LFT) and histopathology. Materials and Methods The baseline parameters of 14 male Sprague–Dawley rats were recorded and then grouped into four groups: treatment groups (high high-dose saroglitazar [HDSG] and low low-dose saroglitazar [LDSG] doses of saroglitazar), normal control, and disease control. Initially, except for the normal control, the other three groups were fed a fructose diet for 5 weeks and then all four groups were fed a standard chow diet for the next 2 weeks during which the two treatment groups were orally gavaged with saroglitazar. Changes in LFT, body weight (BW), lipid profile, oxidative stress, and histopathology were evaluated at different time points. Results A statistically significant reduction was found in the mean serum glutamic-oxaloacetic transaminase (SGOT) ( p = 0.0267) and serum glutamate-pyruvate transaminase (SGPT) ( p = 0.0059) between the groups at the end of treatment. As with BW changes ( p < 0.001), a significant difference was observed between the time points in HDSG and LDSG with respect to all parameters of the lipid profile assessed ( p < 0.05). Amelioration of hepatocellular ballooning and lobular inflammation in histopathology was evident in both treatment groups. Immunohistochemistry revealed loss of cytokeratin CK8/18 in disease control while it was preserved in LDSG and HDSG. Conclusion The study has explicitly illustrated the improvement in the biochemical and pathological changes in the rat model of NASH induced by a high fructose diet.
Mid-term outcomes of three commonly used surgical reconstructions for scapholunate instability
Authors: van Kampen Robert J. , Henk Coert J. , Moran Steven L. 
Published: December 2023

This retrospective analysis reports the mid-term (>2 years) outcomes of capsulodesis, (modified) Brunelli tenodesis and bone-ligament-bone reconstruction for scapholunate ligament instability. In total, 60 patients (64 wrists) returned the Patient-Rated Wrist Evaluation and Disabilities of the Arm, Shoulder, and Hand questionnaires. Of these participants, 42 (46 wrists) returned for a wrist examination and radiographs. In the questionnaire group, the mean follow-up for capsulodesis was 11.8 years, tenodesis 5.9 years and bone-ligament-bone 8.9 years. In the objective outcomes group, the mean follow-up was 10.2 years for capsulodesis, 5.7 for tenodesis and 8.9 for bone-ligament-bone. In all groups, some patients showed radiographic deterioration, which did not always correlate with poor functional outcome. With a mean follow-up greater than 5 years, there was no substantial difference in clinical outcomes and patient-based outcome questionnaires between capsulodesis, tenodesis or bone-ligament-bone reconstruction for the treatment of scapholunate instability. This study emphasizes the need for further research. Surgeons should use the technique that produces the fewest complications. Level of evidence III
Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response
Authors: Teschner Valerie E. , Fleck Ann-Katrin , Walter Carolin , Schwarze Anna-Sophie , Eschborn Melanie , Wirth Timo , Steinberg Olga V. , Schulte-Mecklenbeck Andreas , Lu I-Na , Herrera-Rivero Marisol , Janoschka Claudia , Lünemann Jan D. , Schwab Nicholas , Meyer zu Hörste Gerd , Varghese Julian , Gross Catharina C. , Pul Refik , Kleinschnitz Christoph , Mader Simone , Meinl Edgar , Stoll Monika , Wiendl Heinz , Klotz Luisa 
Published: December 2023

Background: Cladribine is a highly effective immunotherapy that is applied in two short-term courses over 2 years and reduces relapse rate and disease progression in patients with relapsing multiple sclerosis (MS). Despite the short treatment period, cladribine has a long-lasting effect on disease activity even after recovery of lymphocyte counts, suggesting a yet undefined long-term immune modulating effect. Objectives: Our aim was to provide a more profound understanding of the detailed effects of cladribine, also with regard to the patients’ therapy response. Design: We performed an open-labeled, explorative, prospective, single-arm study, in which we examined the detailed lymphocyte subset development of MS patients who received cladribine treatment over 2 years. Methods: We performed in-depth profiling of the effects of cladribine on peripheral blood lymphocytes by flow cytometry, bulk RNA sequencing of sorted CD4+ T cells, CD8+ T cells, and CD19+ B cells as well as single-cell RNA sequencing of peripheral blood mononuclear cells in a total of 23 MS patients before and at different time points up to 24 months after cladribine treatment. Data were correlated with clinical and cranial magnetic resonance imaging (MRI) disease activity. Results: Flow cytometry revealed a predominant and sustained reduction of memory B cells compared to other B cell subsets after cladribine treatment, whereas T cell subsets were slightly reduced in a more uniform pattern. The overall transcriptional profile of total blood B cells exhibited reduced expression of proinflammatory and T cell activating genes, while single-cell transcriptomics revealed that gene expression within each B cell cluster did not change over time. Stable patients displayed stronger reductions of selected memory B cell clusters as compared to patients with clinical or cerebral MRI disease activity. Conclusion: We describe a pronounced and sustained effect of cladribine on the memory B cell compartment, and the resulting change in B cell subset composition causes a significant alteration of B cell transcriptional profiles resulting in reduced proinflammatory and T cell activating capacities. The extent of reduction in selected memory B cell clusters by cladribine may predict treatment response.