bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting of the CD161 inhibitory receptor enhances T-cell–mediated immunity against hematological malignancies
Authors: Alvarez Calderon Francesca , Kang Byong H. , Kyrysyuk Oleksandr , Zheng Shiwei , Wang Hao , Mathewson Nathan D. , Luoma Adrienne M. , Ning Xiaohan , Pyrdol Jason , Cao Xuan , Suvà Mario L. , Yuan Guo-Cheng , Wittrup K. Dane , Wucherpfennig Kai W. 
Published: December 2023

Abstract
The CD161 inhibitory receptor is highly upregulated by tumor-infiltrating T cells in multiple human solid tumor types, and its ligand, CLEC2D, is expressed by both tumor cells and infiltrating myeloid cells. Here, we assessed the role of the CD161 receptor in hematological malignancies. Systematic analysis of CLEC2D expression using the Cancer Cell Line Encyclopedia revealed that CLEC2D messenger RNA was most abundant in hematological malignancies, including B-cell and T-cell lymphomas as well as lymphocytic and myelogenous leukemias. CLEC2D protein was detected by flow cytometry on a panel of cell lines representing a diverse set of hematological malignancies. We, therefore, used yeast display to generate a panel of high-affinity, fully human CD161 monoclonal antibodies (mAbs) that blocked CLEC2D binding. These mAbs were specific for CD161 and had a similar affinity for human and nonhuman primate CD161, a property relevant for clinical translation. A high-affinity CD161 mAb enhanced key aspects of T-cell function, including cytotoxicity, cytokine production, and proliferation, against B-cell lines originating from patients with acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and Burkitt lymphoma. In humanized mouse models, this CD161 mAb enhanced T-cell–mediated immunity, resulting in a significant survival benefit. Single cell RNA-seq data demonstrated that CD161 mAb treatment enhanced expression of cytotoxicity genes by CD4 T cells as well as a tissue-residency program by CD4 and CD8 T cells that is associated with favorable survival outcomes in multiple human cancer types. These fully human mAbs, thus, represent potential immunotherapy agents for hematological malignancies.
Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women’s Studies
Authors: Vu Thanh-Huyen T , Pirzada Amber , Lewis Cora E , Schreiner Pamela J , Liu Kiang , Sternfeld Barbara , Calderon-Margalit Ronit , Merkin Sharon S , Wellons Melissa , Williams O Dale , Kim Catherine , Siscovick David S , Daviglus Martha L 
Published: December 2023

Abstract

Context
There are no reported data from prospective long-term studies on the relation of androgen levels in young women with development of metabolic syndrome (MetS) before menopause.

Objective
We investigated associations of androgens and SHBG with incident MetS during 23 years of follow-up.

Methods
We included 366 White and 375 Black women ages 20 to 32 years participating in the CARDIA study and CARDIA Women’s study, free of MetS at baseline examination (1987-1988), and premenopausal 23 years later. Androgens and SHBG were categorized into quartiles. MetS was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Cox proportional hazards models were used.

Results
By year 23, 30% of women developed MetS. Adjusting for baseline age, race, and education, hazard ratios (95% CI) of developing MetS were 1.46 (1.02-2.10) and 2.22 (1.53-3.21) for women in the highest vs lowest total testosterone (T) and free T quartile, respectively. The hazards of developing MetS were 47%, 59%, and 53% lower for women with SHBG in the second, third, and fourth quartiles (vs lowest quartile), respectively. Associations were attenuated for total T with further adjustments for smoking, physical activity, menstrual status, oral contraceptive/hormone (OCHM) use, insulin level, oligomenorrhea, and age at menarche, but remained statistically significant for free T and SHBG. Associations were similar for both Blacks and Whites, and OCHM nonusers, but not for OCHM users.

Conclusion
High androgenicity in young premenopausal women is associated with higher risk of future MetS, suggesting that early assessment of androgens may contribute to prevention.
Remedios for Relationships: Social Precarity and Amatory Therapeutics in the Early Circum-Caribbean
Authors: Block Kristen 
Published: December 2023

Abstract
This study argues that practices sometimes referred to as “love magic” operated instead as relational therapeutics in colonial Latin America. Focusing on women's roles in Spanish Caribbean port cities from the late sixteenth through the early eighteenth century, I analyze a range of relationship remedios (or cures) ranging from divination and prayers to spells and potions by interrogating early modern Spanish Inquisition records from Mexico and Cartagena de Indias. Far from simple reflections of religious deviance, these trials show women searching within their relational networks for practical remedies to cure structural and personal problems in their sexual partnerships. Some remedies were clearly offered on a basis more transactional than therapeutic, a reflection of the inequality, violence, and trauma of life in the colonial Caribbean. People in the region drew on a range of amatory therapeutics to relieve emotional pain, soothe everyday tensions over power, and cope with economic precarity.
The New Seriality
Authors: Denson Shane 
Published: December 2023

Abstract
Since at least the nineteenth century seriality and serialization have been among the most important formal and narrative strategies for popular media cultures and their negotiations with the radical changes brought on by industrialization and new communication technologies. Nothing less is at stake in popular seriality than the material and spatiotemporal ordering of the phenomenal world, with far-reaching political consequences. However, in an age of computation, predictive algorithms, and “personalized” media, the parameters of serialization are massively transformed. And because media forms and social formations are tightly intertwined, this transformation—or the shift from an “old” to a “new” form of seriality—brings with it crucial changes and uncertainties with respect to subjective and collective existence going forward. Centrally at stake in the new seriality is a set of techniques and technologies that aim to predictively “typify” subjects and preformat them vis-à-vis normative and statistically correlated categories of gender and race, among others. This article lays the groundwork for thinking seriality as a sociotechnics of typification, the scope and power of which is greatly expanded by algorithmic media.
Forging an Anti-Bandung
Authors: Alsudairi Mohammed 
Published: December 2023

Abstract
During the course of the Cold War, Saudi Arabia cultivated close relations with the anti-communist states of East Asia. This development, this article argues, was driven by the shared positional marginality experienced by these actors vis-à-vis the Third World bloc. Unable to participate in the postcolonial possibilities unleashed in the mid-twentieth century, these states drew upon each other's visions of pan-Islamism and anti-communism to forge an “anti-Bandung.” As threats from the global Left intensified by the late 1960s, their reactionary solidarity transformed into an informal yet highly strategic alliance that lasted until the end of the global Cold War. This article calls for a broader conceptualization of inter-Asian and Afro-Asian solidarities that incorporates the narratives and activities of the non-Western Right and provides a new reading of Cold War Saudi Arabia that considers its complicated entanglements with Asia-centric anti-communist internationalism.
Titling in the Ruins
Authors: Kohlbry Paul 
Published: December 2023

Abstract
Palestinian Authority (PA) land titling began in 2005 as a means of creating property and sovereignty. Titling projects are extending government control over Palestinians, but they cannot secure their lands from Israeli state and private power. This article is an ethnography of Palestinian land titling, focusing on the specific problems that fraudulent land transfers to Israeli settlers create for such property-making efforts. It argues that for Palestinian administrators and surveyors, the certainty of Israeli colonization reduces progress to a challenge of speed and gives rise to short-term fixes that defer insoluble legal and political problems. The result is a form of nonsovereign property that encourages land markets now and offers the possibility of securing land rights later. The disjuncture between the future that land titling promises and the present it creates is entrenching private ownership in the West Bank and, as land speculation threatens to erode Palestinian control over territory, inciting debate about its limits. Land titling is creating a new political temporality in the ruins of state-building, one that illuminates how legacies of colonial law and contemporary practices of land speculation shape loss, hope, and contestation in Palestine and across the global South.
Another Third Worldism?
Authors: Bohdan Siarhei 
Published: December 2023

Abstract
This article investigates Iranian–North Korean cooperation after the 1979 revolution in Iran as a case of sustained efforts effectively aimed at implementing Third Worldist ideas. Both Iranian revolutionaries and North Korean Communist officials referred to Third Worldism, although they held different views of it. Their alliance, however, did not rest on ideology alone: by analyzing respective links, the article shows how substate actors following their pragmatic interests have succeeded in bringing about a relatively stable alliance that was rationalized through Third Worldist discourse. In Iran, this relationship was driven by the radical factions of the Khomeinist regime, mostly the so-called Islamic Left. These factions, who controlled some government-affiliated organizations and agencies (e.g., the Revolutionary Guards), needed these foreign links to get the resources necessary to survive and prevail politically. The study is largely based on Iranian sources of the time and memoirs by Iranian officials and activists.
Arwa Salih’s Gendered Critique
Authors: Ryan Brady Patrick 
Published: December 2023

Abstract
This article seeks to clarify the stakes of Arwa Salih’s critical methodology by reading her project—specifically, her development of Milan Kundera’s notion of kitsch, her analytic use of gender, and her formal and political concern with legacy and inheritance—alongside the literary history of iltizam. The article contends that Salih’s critical method and search for ethical knowledge frame iltizam as a form of militant kitsch that prized dogma and readymade answers over ethical and political curiosity. By reading Salih’s historical-political critique in terms of gendered literary symbolism and aesthetics, the article attempts to make clear the resonance of her analytic method in the field of modern Arabic literature—especially Egyptian literature—and to point out how literature and critique are implicated in the social and political changes that forged and solidified Egypt’s neoliberal era.
Abjection of Mother(land)
Authors: Gholami Zhila 
Published: December 2023

Abstract
This article presents a psychoanalytic reading of The Age of Orphans, the first installment of a trilogy by the Kurdish Iranian American novelist Laleh Khadivi. Drawing on Julia Kristeva’s theory of abjection and using close reading, this study explores different forms of abjection in the novel, both thematically and textually. By doing so, the article attempts to uncover the meanings of the novel’s fictional world, as well as its historical, political, and cultural context. Finally, this study, relying on Kristeva’s theory of intertextuality, reveals how the writings of Khadivi, a second-generation immigrant geographically and generationally distant from her Kurdish roots, contribute to Kurdish literature and literary expressions.
State-Led Antigender Politics, Islamism, and the University
Authors: Özbay Cenk , Ipekci Ilkan Can 
Published: December 2023

Abstract
Gender studies and its professors are attacked and oppressed by patriarchal, masculinist, antifeminist, and anti-LGBTI discourses and institutional practices. This trend is not limited to white- and/or Christian-majority countries, as the literature has documented thus far. Antigender campaigns can easily infiltrate Middle Eastern and/or Muslim-majority contexts in which feminists and queers have long struggled to transform societies, cultures, and states. In Turkey a state-led antigender movement has been unfolding, with burdensome outcomes for women and sexual minorities as well as activists and faculty members. The most recent step taken in the state-led antigender turn was Turkey’s withdrawal from the Council of Europe’s Istanbul Convention Action by a precipitous presidential decree. Drawing on thirty-three interviews with gender studies scholars, this article documents their ambivalent and perturbing connection with the state. The recent antigender atmosphere may make them feel downtrodden, silenced, and vulnerable in personal and professional domains, while it rejuvenates their resilience, renders their ongoing feminist/queer struggles meaningful and passionate, and cultivates an air of hope and optimism. To fight ostracism by public institutions and to attain their academic rights, the respondents use their empowering feelings, hope, and commitment against patriarchal and homophobic state forces.
Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study
Authors: Li Huihui , Lin Dinghua , Lin Hongxin , Liu Min , Lu Guangqian 
Published: December 2023

Objective: To explore the efficacy of Danshen injection combined with calcitriol and calcium/Vitamin-D in the treatment of osteoporotic fractures.
Methods: This was a case–control study. We retrospectively reviewed clinical data of 91 patients with osteoporotic fractures who received treatment in Rui’an People’s Hospital from February 2021 to July 2022. The data were divided into a control group with 44 records of patients who received treatment with calcitriol and calcium/Vitamin-D, and a study group with 47 patients who received Danshen injection combined with calcitriol and calcium/Vitamin-D. The control group individuals were coordinated with the patients in terms of their age and gender. Treatment effects, inflammatory response levels, and bone metabolic status levels were comparable between the two groups before and after the treatment.
Results: The total efficacy of the treatment in the study group was better than that in the control group (P<0.05). After the treatment, levels of serum inflammatory factors in both groups decreased compared to those before the treatment, and the study group displayed lower levels than the control group (P<0.05). After the treatment, the bone metabolism status of both groups improved, and the improvement effect of the study group was better (P<0.05). The incidences of adverse reactions were similar in both groups (P>0.05).
Conclusions: Danshen injection combined with calcitriol and calcium/Vitamin-D for the treatment of osteoporotic fractures can effectively reduce inflammation, regulate bone metabolism, and improve fracture treatment efficacy with a favorable safety profile.
doi: https://doi.org/10.12669/pjms.40.3.8513
How to cite this: Li H, Lin D, Lin H, Liu M, Lu G. Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study. Pak J Med Sci. 2024;40(3):291-296. doi: https://doi.org/10.12669/pjms.40.3.8513
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Proximity and Knowledge Spillovers: Evidence from the Introduction of New Airline Routes
Authors: Bai John (Jianqiu) , Jin Wang , Zhou Sifan 
Published: December 2023

This paper examines the causal relationship between proximity and knowledge diffusion by estimating the elasticity of core-based statistical area (CBSA) pair-level citations to variations in travel time induced by the introduction of new flight routes. The findings reveal that decreasing travel time between U.S. cities by 20% increases knowledge flow by 0.5%, which corresponds to an increase of over 15,000 citations at the aggregate level. Rather than boosting within-firm knowledge transfer, travel time reduction leads to a rise in knowledge spillovers primarily across firm boundaries, particularly among those that form joint ventures, have block holdings in each other, or form supply chain relationships. These effects are stronger among city pairs located farther away from each other, with higher absorptive capacity, in complex technology classes, and for newly developed technologies. Additional mechanism tests suggest that the most likely channel through which travel time reduction impacts knowledge spillover is by influencing the transfer of tacit knowledge via facilitating cross-CBSA inventor flow and information acquisition. This paper was accepted by Tomasz Piskorski, finance. Funding: S. Zhou receives support from the National Natural Science Foundation of China [Grant 71804155] and China Fundamental Research Funds for the Central Universities [Grant 20720181047]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.01717 .
Typische Profile digitaler Kompetenzen: Eine clusteranalytische Untersuchung digitaler Kompetenzen im Arbeitskontext
Authors: Merchel Robin , Kampschulte Kathleen , Nauth Kathrin , Pöppelbuß Jens 
Published: December 2023

ZusammenfassungTypologien reduzieren die Vielfalt menschlicher Merkmale auf eine geringe Zahl an Merkmalsausprägungen, die die Wirklichkeit vereinfachend abbilden und so die Ableitung organisationaler Interventionen ermöglichen. Für den Umgang von Menschen mit der Digitalisierung wurden bereits mehrere Typologien mit vier bis sieben Typen bzw. Clustern aufgestellt, wobei dies z. B. auf Basis der Intensität der Mediennutzung, der Begeisterung für digitale Umbrüche oder der Fähigkeiten der Beschäftigten geschah. In der vorliegenden Arbeit werden neun digitale Kompetenzen von n = 645 Beschäftigten im Rahmen einer Fragebogenstudie (Oktober 2021–April 2022) erfasst. Mithilfe einer Clusteranalyse werden vier typische Profile digitaler Kompetenzen identifiziert, die als (1) begeistertes, (2) balanciertes, (3) naives und (4) ablehnendes Cluster bezeichnet werden. Die vier Cluster zeigen Zusammenhänge zu den wahrgenommenen organisationalen Lernmöglichkeiten, zum Techno-Engagement und zum Persönlichkeitsmerkmal der Offenheit. Sie spiegeln bisherige Forschung zur Typologisierung von Beschäftigten im Umgang mit der Digitalisierung präzise wider. Somit stellen sie ein generalisierbares, stabiles und bedeutsames Muster dar, das für organisationale Interventionen zur Steigerung der digitalen Kompetenzen und der Bereitschaft für digitale Umbrüche genutzt werden kann.
Multi-Case-Studie zu Barrieren und förderlichen Faktoren der digitalen Kompetenz von Patienten – Ein interdisziplinärer Ansatz
Authors: Kählig Maren , Susky Marcel , Hickmann Emily , Grummt Sophia , Richter Daniela , Richter Peggy , Weidner Jens , Sedlmayr Martin , Seim Anne 
Published: December 2023

ZusammenfassungDie rasanten Fortschritte digitaler Technologien haben die Gesundheitsversorgung revolutioniert und dabei unter anderem die Vernetzung von Patienten, Gesundheitsdienstleistenden, Entwicklern und Forschenden in den Mittelpunkt gerückt. Um das volle Potenzial dieser Transformation auszuschöpfen, ist es von entscheidender Bedeutung, die digitalen Kompetenzen der Patienten und des medizinischen Fachpersonals zu fördern. Besonders vor dem Hintergrund des demografischen Wandels wird das Verständnis und die Anwendung digitaler Innovationen in der Gesundheitsversorgung zu einer Schlüsselaufgabe.Unsere Forschungsarbeit konzentrierte sich daher auf eine Multi-Case-Studie im Rahmen des „Medical Informatics Hub for Saxony“, um die für die erfolgreiche Nutzung digitaler Gesundheitstechnologien benötigten digitalen Kompetenzen von Patienten zu identifizieren. Um einen strategischen Ansatz für den Aufbau dieser Fähigkeiten entwickeln zu können, untersuchten wir zudem Einflussfaktoren auf diese Kompetenzen.Die Ergebnisse unserer Studie verdeutlichen, dass die Digitalisierung zwar bereits im Alltag der Patienten präsent ist, Bedenken hinsichtlich der Datensicherheit jedoch ein Hemmnis für die Nutzung digitaler Innovationen darstellen. Hier spielt die Kommunikation und Interaktion mit medizinischem Fachpersonal eine entscheidende Rolle, um diese Barrieren abzubauen und dem Bedürfnis nach sozialer Interaktion im Zusammenhang mit digitaler Technologie gerecht zu werden. Die Vermittlung grundlegender Soft Skills sowohl an medizinisches Personal als auch an Patienten, eine transparente Kommunikation über Datenschutzregelungen und den Zweck freiwilliger Datenspenden sowie interdisziplinäre Schulungsprogramme, die technische Anforderungen und auch soziale Aspekte berücksichtigen, sind daher von großer Bedeutung.Unsere Studie betont die Wichtigkeit einer einfühlsamen und individuellen ärztlichen Betreuung, um Ängste und Vorbehalte auf Patientenseite abzubauen und digitale Gesundheitstechnologien effektiv einsetzen zu können. Dieser ganzheitliche Ansatz wird entscheidend dazu beitragen, die Potenziale der Digitalisierung im Gesundheitswesen voll auszuschöpfen.
Addressing patients’ unmet needs related to multidrug-resistant tuberculosis (MDR-TB) care: A qualitative research study from Pune city, India
Authors: Atre Sachin , Jagtap Jayshri , Faqih Mujtaba , Dumbare Yogita , Sawant Trupti , Ambike Sunil , Farhat Maha 
Published: December 2023

Aim
We aimed to identify and describe the unmet needs of patients with multidrug-resistant tuberculosis (MDR-TB).

Methods
As a part of larger cross-sectional mixed-methods (qualitative and quantitative data) study on pathways to MDR-TB care, here we present the qualitative component. We interviewed 128 (56 men and 72 women) individuals who had MDR-TB, aged > = 15 years, registered and treated under the National TB Elimination Program (NTEP) in Pune city of India. We carried out thematic analysis of participants’ narratives.

Results
We found that delays in diagnosis, lack of counseling, late referral to the NTEP and unwarranted expenditure were the main barriers to care that study participants experienced in the private sector. Provider dismissal of symptoms, non-courteous behavior, lack of hygiene in the referral centers, forced stay with other patients and lack of support for psychological/psychiatric problems were identified as a few additional challenges that participants faced at the NTEP care centers.

Conclusion
Using qualitative data from experiences of participants with MDR-TB, we identify patients’ several unmet needs, attention to which can improve MDR-TB care. Educating private providers about MDR-TB risk and available rapid molecular assays can help the timely diagnosis of MDR-TB and reduce patients’ out of pocket costs. At the RNTCP/NTEP, measures such as training health workers to build rapport with patients, maintaining hygienic environments in the health centers with adequate isolation of participants with MDR from other serious cases, referral of patients with psychiatric symptoms to mental health specialists and monitoring drug shortages can help in improving care delivery.