bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex oncologic reconstruction of a mandibular and floor of mouth defect with a fibula free flap in an achondroplastic patient
Authors: García‐Rozado Alvaro , Martín Sastre Roberto J. , López Cedrún José L. 
Published: August 2003

AbstractThe fibular free flap is seen as one of the foremost technical options in mandibular reconstruction, especially in those defects where long bone is required. Cases with squamous‐cell carcinoma of the floor of the mouth with mandibular spread and subsequent segmentary mandibular removal are the cornerstone examples. A case of squamous‐cell carcinoma of the whole floor of the mouth with mandibular invasion is reported. Radical resection of the floor of the mouth and bilateral mandibular horizontal ramus was performed, with a bony defect extending from angle to angle. The patient revealed an achondroplastic condition, with remarkable dwarfism and long‐bone morphological alterations, that minimized the potential fibular length to transfer. A microsurgical reconstruction with an osteocutaneous fibular free flap was undertaken. The flap design was technically compromised by the forward bowing of the fibula and the ossification of the interosseous membrane. Specific intraoperative strategies for dealing with anatomic variations are discussed. The fibular free flap is an excellent technique for mandibular reconstruction. Morphological deviations can modify the design of the flap. Achondroplasia is not a deterrent in successful use of the free fibula flap for reconstruction of the head and neck in adequately selected cases. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:296–305 2003
End‐to‐side neurorrhaphy: An experimental study in rabbits
Authors: Jaberi Fereidoon Mojtahed , Abbas Babak Pour , Nezhad Simin Torabi , Tanideh Nader 
Published: August 2003

AbstractThe concept of end‐to‐side nerve repair was recently introduced; however, most authors have reported conflicting results with this technique. This study was conducted to assess the effectiveness of end‐to‐side nerve repair in both fresh and predegenerated specimens by histological evaluation in an animal study in rabbits. Thirty male rabbits were divided into three groups. In group 1 (n = 14), the peroneal nerve was divided and sutured end‐to‐side to the tibial nerve via an epineurial window. In group 2 (n = 13), the peroneal nerve was divided and sutured end‐to‐side to the tibial nerve after a 1‐week “predegeneration period.” In group 3 (n = 3), which was considered the control group, the peroneal nerve was divided and sutured to the adjacent soft tissues. After 3 months, specimens were harvested for histological evaluation. Nerve fiber count, in normal peroneal nerves, averaged 532/cross section. In groups 1 and 2, average nerve fiber count in implanted peroneal nerves was 6.24 and 7.00/cross section, respectively. No significant statistical difference was observed between fresh and “predegenerated” groups (P = 0.90). These data suggest that collateral sprouting of donor nerves is possible after end‐to‐side neurorrhaphy through an epineurial window, but the number of nerve fibers in recipient nerves is too low to result in any functional recovery in the target organ. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:359–362 2003
Nutritive perfusion at donor site after microvascular fibula transfer
Authors: Hölzle Frank , Swaid Sami , Nolte Dirk , Wolff Klaus‐Dietrich 
Published: August 2003

AbstractThere are many reports on the versatility of the fibular flap, but only a few studies have reported on the morbidity, and none on the nutritive perfusion, of the donor site. This study describes for the first time the quantitative investigation of nutritive perfusion at the donor site after osteomyo‐cutaneous fibula transfer. Tissue nutrition of the lower leg was measured in 25 patients by micro‐lightguide spectrophotometry and laser Doppler flowmetry. In a standardized examination, hemoglobin oxygenation and blood flow of the donor leg and the contralateral leg (intraindividual control) were measured at the nutritive region of the peroneal artery (I), posterior tibial artery (II), and anterior tibial artery (III). In the operated leg, blood flow was significantly reduced in region I with the sacrificed peroneal artery, and significantly increased in region II and III, probably for compensation (P = 0.03). Decreased hemoglobin oxygenation and blood flow of the peroneal region at the donor site were without significance in comparison to the control leg (P = 0.55 and P = 0.35, respectively). Decreased nutritive perfusion at the donor site was below the threshold of clinical manifestation, and supports the low donor site morbidity following fibular grafting. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:306–312 2003
Effects of vinblastine on healing in microvascular anastomosis
Authors: Tatlidede Soner , Karsidag Semra Hacikerim , Tosun Ugur , Kabukcuoglu Fevziye , Gul Mustafa , Kuran Ismail 
Published: August 2003

AbstractReconstructive microsurgical procedures are getting more common in cancer patients. Adjuvant therapies, such as chemotherapy, radiotherapy, and immune therapy, are usually combined with surgical approaches to improve outcomes. This study was designed to investigate the effects of preoperative chemotherapy on healing in microvascular anastomosis. As a commonly preferred drug for neoadjuvant cancer treatment, vinblastine was used on rats in our study. Ninety‐three Sprague‐Dawley rats were used and randomly allocated into two groups as 72 experimental and 21 control rats. Vinblastine 2 mg/kg was administered as a single dose intraperitoneally on day 0 in the experimental group. Leukocytes and erythrocytes were counted on days 0, 1, 3, 5, 7, 10, and 15 in 6 rats of the experimental and 6 rats of the control group. We found that the neutropenia period ended on approximately day 7. After applying the medication, the experimental group (n = 72) was divided into three main groups (n = 24). We performed end‐to‐end femoral artery anastomosis on days 7 or 14 or 21, respectively, in each group. Each main group was divided into three subgroups (n = 8), and then we tested patency and took biopsies on days 7 or 14 or 21, respectively, in each subgroup. Histopathologic evaluation was carried out. The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:354–358 2003
Ultrarapid nonsuture mated cuff technique for renal transplantation in rabbits
Authors: Wu Jun , Ge Xian , Fahy Gregory M. 
Published: August 2003

AbstractAn effective and ultrarapid technique for kidney transplantation in the rabbit is introduced. Vascular anastomosis was completed using a novel cuff technique in which mating cuffs were used to join the delicate renal vein. The ureter was reconstructed by spatulated end‐to‐end anastomosis, with special attention to the rabbit's unique ureteral vascular anatomy. The total vascular anastomosis time was 3.4 ± 1.3 min, and there were no episodes of bleeding or thrombosis. The ureter complication rate was 7.3%. Kidneys transplanted after 5 h of cold storage using the new technique yielded better postoperative creatinine results than similar preserved kidneys transplanted using previously described methods. We suggest this technique for studies of long‐ and short‐term kidney preservation and transplantation in the rabbit, as well as for veterinary transplantation in which donor kidneys must be stored for only a short time before use. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:369–373 2003
Microvascular repair following crush‐avulsion type injury with vein grafts: Effect of direct inhibitors of thrombin on patency rate
Authors: Gravvanis Andreas I. , Tsoutsos Dimosthenis A. , Lykoudis Efstathios G. , Iconomou Thomais G. , Tzivaridou Despina V. , Papalois Apostolos E. , Patralexis Charalampos G. , Ioannovich John D. 
Published: August 2003

AbstractThe aim of this study was to develop a standardized effective thrombogenic arterial anastomosis model, as usually encountered in clinical practice, and to offer a detailed evaluation of the antithrombotic effect of thrombin's direct inhibitors, antithrombin III and hirudin, as locally applied. Wistar rats were divided into four groups of 12 animals each. The carotid artery sustained a standardized crush‐avulsion‐type injury (groups B–D). A segment of the afflicted area was removed and replaced by a microvenous graft. Group A had no crush‐avulsion injury inflicted; a microvenous graft replaced a simple resection from the center of the carotid artery. During microvascular anastomoses, normal saline (groups A and B), recombinant hirudin (group C), or antithrombin III (group D) were locally applied. Bleeding times were recorded, and patency tests were performed 20 min, 48 h, and 1 week after blood flow reestablishment. All grafts were harvested and examined histologically. Patency tests, 1 week postrevascularization, demonstrated that this experimental crush‐avulsion injury model ensured low patency in group B (25%), whereas group A, which had no injury inflicted, achieved a 100% patency rate. The local application of hirudin and antithrombin III significantly increased bleeding times as well as the patency rate (92% and 75%, respectively) compared to group B. These findings indicate the efficiency of the experimental model and the potential use of thrombin's direct inhibitors in microvascular surgery. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:402–407 2003
Morphology of nerve fiber regeneration along a biodegradable poly (DLLA‐ϵ‐CL) nerve guide filled with fresh skeletal muscle
Authors: Varejão Artur S.P. , Cabrita António M. , Meek Marcel F. , Fornaro Michele , Geuna Stefano , Giacobini‐Robecchi Maria G. 
Published: August 2003

AbstractPrevious morphological and morphometrical studies showed that fresh‐skeletal‐muscle‐enriched vein segments are good conduits for leading peripheral nerve regeneration. In the present study, we investigated the morphological features of peripheral nerve fibers regenerated along a 10‐mm‐long biodegradable poly (DLLA‐ϵ‐CL) nerve guide enriched with fresh skeletal muscle, comparing them to nerve fiber regeneration along 10‐mm‐long phosphate‐buffered saline (PBS)‐enriched poly (DLLA‐ϵ‐CL) tubes. Repaired nerves were analyzed at weeks 6 and 24 postoperatively. Structural and ultrastructural observation showed that good nerve fiber regeneration occurred in both PBS‐enriched and fresh‐skeletal‐muscle‐enriched nerve guides, and histomorphometrical analysis of regenerated myelinated fibers revealed no statistically significant differences between the two experimental groups at week 24 after surgery. The employment of fresh‐muscle‐enriched conduits for the repair of nerve defects is critically discussed in the light of these results. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:338–345 2003
Functional assessment of sciatic nerve recovery: biodegradable poly (DLLA‐ϵ‐CL) nerve guide filled with fresh skeletal muscle
Authors: Varejão Artur S.P. , Cabrita António M. , Geuna Stefano , Patrício João A. , Azevedo Horácio R. , Ferreira António J. , Meek Marcel F. 
Published: August 2003

AbstractThe aim of this study was to compare functional peripheral nerve recovery in the rat sciatic nerve model after reconstruction of a 10‐mm gap with a biodegradable poly (DLLA‐ϵ‐CL) nerve guide, as filled with either fresh skeletal muscle or phosphate‐buffered saline (PBS). During 24 weeks of recovery, motor and sensory functional evaluation was tested by extensor postural thrust (EPT) and withdrawal reflex latency (WRL), respectively. At the end of the experiment, anesthetized animals were prepared for motor nerve conduction velocity (MNCV) studies, followed by gastrocnemius and soleus muscle weight measurement. Motor functional recovery was greater in the muscle‐grafted group, and reached a significant difference from weeks 8–12 (P < 0.05). The results of this investigation suggest that filling a nerve guide with fresh skeletal muscle induces faster maturation of regenerated nerve fibers in comparison with traditional tubular repair. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:346–353 2003
Strain differences in autotomy in mice after peripheral nerve transection or repair
Authors: Rubinstein Roee E. , Deem Kenneth C. , Jensen John , MacKinnon Susan E. , Tung Thomas H. 
Published: August 2003

AbstractThe purpose of this study was to identify the optimal murine model for the study of peripheral nerve injury and nerve and limb transplantation. The degree of self‐mutilation (autotomy) following sciatic and saphenous nerve injury was assessed in four mouse strains, Balb/C, C57BL/6J, C57BL/10J, and C3HEB, commonly used in surgical research. Experimental groups included sciatic and saphenous nerve transection with repair (n = 9) or without repair (n = 9), as well as housing arrangements favoring social interaction vs. isolation. Autotomy was most prevalent in the Balb/c and C3H strains at 56% and 89% overall, respectively, and was much less frequently seen in the C57Bl/10 and C57Bl/6 strains (22% and 11%, respectively). Autotomy was found to correlate most strongly with mouse strain, and with social contact as well. Two strains, C57BL/6J and C57BL/10J, were found to be highly resistant to self‐mutilation, and are thus ideal animal models for peripheral‐nerve and whole‐limb transplant studies. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:363–368 2003
Effect of torsion on microvenous anastomotic patency in a rat model and early thrombolytic phenomenon
Authors: Bilgin S. Sinan , Topalan Murat , Ip W.Y. , Chow S.P. 
Published: August 2003

AbstractTorsion at the microanastomosis site is a basic fault and should be avoided. In this study, we investigate the effects of different degrees of microvenous torsion on patency and its physical changes on anastomoses in a rat model. One hundred anastomoses were performed at different degrees of torsion, using femoral veins of Sprague‐Dawley rats. Anastomoses were performed at 0°, 45°, 90°, 135°, and 180° of torsion randomly. Patency tests immediately, 1 h, and 1 week after the anastomoses were checked, using the refill test. Measurements of external diameter were recorded at three points: one at the anastomosis site, and the others 2 mm proximal and distal to the anastomotic site. Finally, histopathologic and scanning electron microscopy studies were performed. Subsequently, because of the peculiar phenomenon of early recannulation of the thrombosed vessels, 20 vessels were also explored on the first and the third days postoperatively. The data demonstrate that torsion at 180°, compared with 0°, 45°, and 90°, impaired patency significantly (P < 0.005). In the subsequent study of 20 veins that were thrombosed on the first day, all became patent on the third day and remained so. In conclusion, rotation of a microvenous anastomosis begins to affect the patency rate at 90° of torsion, and at 180° has a patency rate of only 25%. However, all become patent again from the third day onwards. Thrombosis of rat femoral veins without chronic obstruction results in rapid lysis of thrombus and transient proliferative changes. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:381–386 2003
Neurovascular anatomy of the rectus femoris flap in the rabbit
Authors: MacQuillan Anthony , Grobbelaar Adriaan 
Published: August 2003

AbstractThe rectus femoris muscle in the rabbit represents a reliable flap for experimental work in many aspects of microsurgery. The operative exposure of the flap is often tricky for those unfamiliar with the anatomy, as is isolation of its neurovascular pedicle. Experience with 59 consecutive rectus femoris flaps demonstrated five separate patterns of arteral and venous pedicles. The nervous anatomy was found to be constant. Once recognized, these vessel patterns can be used to facilitate pedicle dissection, thus minimizing intraoperative mistakes which may endanger the viability of the flap. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:395–401 2003
Validation of novel and objective measures of microsurgical skill: Hand‐motion analysis and stereoscopic visual acuity
Authors: Grober Ethan D. , Hamstra Stanley J. , Wanzel Kyle R. , Reznick Richard K. , Matsumoto Edward D. , Sidhu Ravindar S. , Jarvi Keith A. 
Published: August 2003

AbstractOur purposes were: 1) to establish the predictive validity of stereoscopic visual acuity and microsurgical performance, and 2) to establish the construct and concurrent validity of hand‐motion analysis as an objective and sensitive measure of microsurgical performance. Using a surgical microscope, 50 surgical residents completed a standardized microsurgical suturing task at baseline and following microsurgical training. Microsurgical performance was evaluated by blinded, expert microsurgeons using global rating scales. Measures of stereoscopic visual acuity and hand‐motion analysis were correlated with expert global rating scores. Global rating scores correlated significantly with number of hand movements (r = −0.47, P = 0.001) and hand‐travel distance (r = −0.37, P = 0.008). Economy of hand‐motion improved significantly following microsurgical training (number of hand movements, P = 0.046; hand‐travel distance, P = 0.04). Measures of stereoscopic visual acuity did not correlate significantly with global rating scores. Hand‐motion analysis appears to be an objective and sensitive instrument for assessing microsurgical performance, with evidence of both concurrent and construct validity. The predictive validity of stereoscopic visual acuity and microsurgical performance remains unclear. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:317–322 2003
Free latissimus dorsi flap used in treatment of cerebral aspergillosis: A case report and review of the literature
Authors: Antony Anuja K. , Hong Roy W. , Amieva Manuel , Taekman Michael S. , Huhn Stephen L. , Karanas Yvonne L. 
Published: August 2003

AbstractCerebral aspergillosis infection is a rare disease in children that carries extremely high morbidity and mortality. Although occurring most commonly in the immunosuppressed patient, cerebral aspergillosis infection has been reported after trauma or neurosurgical procedures. Amphotericin B is the main medical therapy for cerebral aspergillosis. However, surgical treatment is often required for cases of abscess or granuloma formation. Despite aggressive antifungal treatment and surgical intervention, aspergillosis of the central nervous system is often fatal. We present a case report in which a free latissimus dorsi muscle flap was used in conjunction with antifungal medication and surgical debridement to treat intracranial and epidural aspergillosis in a young male following complex craniofacial trauma. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:313–316 2003
Distally based radial forearm flap with preservation of the radial artery: Anatomic, experimental, and clinical studies
Authors: Chang Shi‐Min , Hou Chun‐Lin , Zhang Feng , Lineaweaver William C. , Chen Zhong‐Wei , Gu Yu‐Dong 
Published: August 2003

AbstractIn this article we report on the anatomical, experimental, and clinical investigations of the distally adipofascial pedicled radial forearm flap based on the small perforators around the radial styloid process. There are about 10 small perforators (0.3–0.5 mm in diameter) from the distal radial artery around the radial styloid process. The longitudinal chain‐linked vascular plexuses (suprafascial, paraneural, and perivenous) formed by the forearm ascending and descending branches of septofasciocutaneous perforators meet and cross over with the transverse carpal vascular plexuses around the radial styloid region. Based on these directional‐oriented plexuses, distally based adipofascial pedicled radial forearm fasciocutaneous and adipofascial flaps were designed and successfully applied in 34 clinical cases. The pivot point was located at 1–2 cm above the radial styloid. The skin island plus adipofascial pedicle measured between 9–18 cm in length, with the adipofascial pedicle 3–4 cm in width. The length‐to‐width ratio is 3–5:1. The venous drainage of this distally based flap was investigated anatomically and experimentally. The cephalic vein has no positive role for venous drainage in distally based flaps. The difference between distally based flaps and reverse‐flow flaps, clinical selection of fasciocutaneous and adipofascial flaps, advantages and disadvantages, and technical tips for operative success are discussed. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:328–337 2003
Effect of exercise on microsurgical hand tremor
Authors: Hsu Patricia A. , Cooley Brian C. 
Published: August 2003

AbstractThis study investigated the effects of upper‐body and aerobic/lower‐body‐only (nonupper‐body) exercise on microsurgical hand tremor. Subjects were given a task of holding a microsurgical needle tip over a small target, with video‐microscopic documentation immediately before and 0, 2, 4, 8, and 24 h after either upper‐body or nonupper‐body (aerobic) exercise. Tremor was quantified by the amount of time the needle was maintained within a 100 × 100‐μm target zone and the number of times the needle extruded from the zone. Both upper‐body and aerobic‐only exercise groups had significant increases in tremor immediately after exercise (P < 0.02), with a return to baseline tremor 2 h after exercise in the aerobic group and only a slightly prolonged return to baseline (by 4 h) in the majority of upper‐body exercise subjects. These findings demonstrate that microsurgical hand tremor increases following exercise, but returns to baseline within 4 h in the majority of individuals, particularly after aerobic‐only workouts. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:323–327 2003
Enhanced impedance bandwidth of microstrip antennas using coupling
Authors: Lee Byungje , Harackiewicz France J. , Kang Gi‐Cho , Hong Uiseok , Lee Jong‐Chul , Kim Bok‐Ki 
Published: August 2003

AbstractThis paper presents measured results for the improved bandwidth of a microstrip antenna using coupling techniques in conjunction with matching circuits. The proposed technique is applied to probe‐fed and aperture‐coupled microstrip antennas. The measured bandwidth for a probe‐fed and an aperture‐coupled antenna is increased up to about 14%, which can be further increased by obtaining the proper size of the impedance locus and using the matching technique. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 39: 79–81, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11133
On forming a symmetrical broad‐beam utilizing a paired curved‐leakywave structure
Authors: Ohtera Isao 
Published: August 2003

AbstractIn this article, an easy method for forming a symmetrical broad‐beam, utilizing a paired curved‐leakywave structure (CLS), is proposed. These radiation structures can be used as millimeter‐wave antennas in relatively short‐range communication, such as indoor wireless LAN and intelligent transport system (ITS). © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 39: 86–88, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11135
Efficient analysis of large phased arrays using iterative MoM with DFT‐based acceleration algorithm
Authors: Ertürk V. B. , Chou Hsi‐Tseng 
Published: August 2003

AbstractA discrete Fourier transform (DFT)‐based iterative method of moments (IMoM) algorithm is developed to provide anO(Ntot) computational complexity and memory storages for the efficient analysis of electromagnetic radiation/scattering from large phased arrays. Here,Ntotis the total number of unknowns. Numerical results for both printed and free‐standing dipole arrays are presented to validate the algorithm's efficiency and accuracy. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 39: 89–94, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11136