bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Tenapanor in Managing Hyperphosphatemia and Constipation in Hemodialysis Patients: A Randomized Controlled Trial
Authors: Suzuki Naoki , Takeda Yuuki , Kabuto Akie , Konishi Takao , Konishi Takahiro , Sumino Fumi , Iwata Hayanari , Iwagami Mone , Kouchi Yusuke , Hitomi Yasumasa , Takatani Toru , Nishimura Masato , Sato Nodoka 
Published: February 2025

AbstractIntroductionTenapanor is a minimally absorbed, small-molecule inhibitor of sodium/hydrogen exchanger 3 and thus suppresses sodium absorption in the gastrointestinal tract. It is approved by the FDA for the treatment of hyperphosphatemia in dialysis patients. This randomized controlled trial evaluated its efficacy in the treatment of hyperphosphatemia and constipation in hemodialysis patients.MethodsNinety hemodialysis patients were randomized 1:1 to receive either tenapanor or standard care. Randomization was performed using a computer-generated sequence stratified by baseline serum phosphorus levels. The tenapanor group began treatment with a dosage of 10 mg/day, which was adjusted based on serum phosphorus levels. Primary outcomes were changes in serum phosphorus levels in the tenapanor and control groups and changes in stool consistency, assessed weekly using the Bristol Stool Form Scale (BSFS) in the tenapanor group. Secondary outcomes included laxative use and phosphate binder prescription patterns. Serum phosphorus levels, serum calcium, albumin, and related biochemical parameters were monitored every two weeks. Data were analyzed using intention-to-treat principles. This study was not blinded.ResultsOf the 90 randomized participants, 69 completed the 23-week study. Tenapanor significantly improved stool consistency and resolved constipation (BSFS types 1-2) by week 5. A transient increase in loose stools (BSFS types 6-7) occurred early, with 10 participants discontinuing due to diarrhea. Laxative use decreased significantly in the tenapanor group, from 58.2% at baseline to 35.6% at week 23 (p < 0.01). Serum phosphorus levels were decreased in both groups, with comparable control. Lanthanum carbonate prescriptions decreased significantly in the tenapanor group and were largely replaced by low-dose tenapanor.ConclusionTenapanor improves stool consistency, reduces laxative use, and provides effective phosphorus control in hemodialysis patients and represents a promising alternative to conventional phosphate binders.FundingNone.Trial RegistrationRegistered with UMIN-CTR (UMIN000033778;http://www.umin.ac.jp/ctr/index.htm).
Time-course responses following sports-related concussion: A multi-modality study
Authors: Pearce Alan J , Middleton Kane , Clarke Anthea 
Published: February 2025

AbstractObjectivesUsing a repeated-measures design, we investigated reported symptoms, oculomotor, and neurophysiological responses for up to 26 days following a sports-related concussion.MethodsOver the course of one season, 115 athletes (mean age 26.2 ± 5.4 years) from one football team (f=28, m=37) and one ice hockey team (f=21, m=29) were assessed for self-reported symptoms and severity of symptoms, cognitive testing for 10-word recall and digit backwards. Oculomotor performance was assessed using eye-pursuits. Neurophysiology was assessed using transcranial magnetic stimulation. Baseline data was tested during pre-season for all athletes and, when a concussion was identified, carried out at 48h, 12-, 19-, and 26-days post injury.ResultsTwenty-two players suffered concussion injuries (f=10, m=12). Significant increases in symptoms were reported at 48-hours (p<0.001) and 12-days (p=0.017). Severity of symptoms were significantly increased at 48-hours only (p=0.002). Significant decrements in performance for 10-word recall (p=0.003), digit backwards (p=0.011), and eye-pursuit (p=0.009) were observed at 48-hours in comparison to baseline. Transcranial magnetic stimulation revealed significantly increased cortical inhibition at 48-hours (p=0.024), 12- (p=0.009), and 19-days (p=0.028) compared to baseline. No differences were seen between females and males for any variables or timepoints.ConclusionConcussed players show acute changes in cortical inhibition, resolving by 26-days after injury, which follows a longer time-course for recovery compared to symptoms, cognitive tests, and oculomotor eye-pursuits. These results suggest that measuring the recovery of concussed athletes should incorporate a range of testing modalities in the determination of a player’s readiness to return to play.
Arabidopsisroot-type ferredoxin:NADP(H) oxidoreductases are crucial for root growth and ferredoxin-dependent processes
Authors: Monden Kota , Otomaru Daisuke , Suzuki Takamasa , Nakagawa Tsuyoshi , Hachiya Takushi 
Published: February 2025

AbstractRoot-type ferredoxin:NADP(H) oxidoreductase (RFNR) is believed to reduce ferredoxin using NADPH in nonphotosynthetic tissues, facilitating ferredoxin-dependent biological processes. However, the physiological functions of RFNR remain unclear due to the difficulty in obtaining mutants lacking redundant RFNR isoproteins. The present study successfully generatedArabidopsishomozygousrnfr1;2double mutants by traditional crossing and selection. However, they displayed severely stunted roots, challenging subsequent growth and abundant seed recovery. Notably, grafted plants combining mutant scions with wild-type rootstocks exhibited normal growth and produced abundant mutant seeds. Growth analysis employing reciprocal grafts with the wild-type and mutant plants showed that primary root growth was inhibited only when the rootstock was derived from the mutants. Meanwhile, the absence of RFNR1 and 2 in the scion had no apparent impact on shoot and root growth. Root transcriptome analysis revealed that RFNR1 and 2 deficiency upregulated genes encoding ferredoxin-dependent enzymes and root-type ferredoxin, leading to genome-wide reprogramming associated with cell walls, lipids, photosynthesis, secondary metabolism, and biotic/abiotic stress responses. Thus,ArabidopsisRFNR1 and 2 are crucial for root growth and various ferredoxin-dependent biological processes.
Prenatal adversity configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety
Authors: Nabila Anika , Sciortino Rose , Politowska Nicole , Brindley Elizabeth , Hámor Peter U. , Zallar Lia , Toth Judit Gal , Pleil Kristen , Toth Miklos 
Published: February 2025

ABSTRACTAdverse prenatal environment is a risk factor for the development of psychiatric disorders. Although studies have implicated epigenetic mechanisms, little is known about how epigenomic changes come about and lead to abnormal behaviors in affected individuals. We sought to identify epigenomic and transcriptomic signatures induced by a proinflammatory gestational environment in the ventral dentate gyrus (vDG), a hippocampal region linked to avoidance of threatening contexts, that persist and promote anxiety-like behavior in mice. Here we show that adversity shifted the methylation of enhancers and promoters with intermediate methylation and altered synapse-related gene expression, resulting in epigenetic and transcriptional heterogeneity in the vDG. Exposure to an anxiogenic environment recruited vDG neurons with the most transcriptional alterations. Differentially expressed synapse-relevant genes in ensemble neurons tended to be differentially methylated. Finally, this ensemble exhibited higher activity in threatening than safe environment suggesting a prenatal adversity-induced epigenetic and neurobiological sequence that leads to anxiety.
Binding of the three-hadron
DD*K
system from the lattice effective field theory
Authors: Zhang Zhenyu , Hu Xin-Yue , He Guangzhao , Liu Jun , Shi Jia-Ai , Lu Bing-Nan , Wang Qian 
Published: February 2025

We employ the nuclear lattice effective field theory (NLEFT), an efficient tool for nuclear calculations, to solve the asymmetric multihadron systems. We take the DD*K three-body system as an illustration to demonstrate the capability of the method. Here the two-body chiral interactions between D, D*, and K are regulated with a soft lattice regulator and calibrated with the binding energies of the Tcc+, Ds0*(2317), and Ds1(2460) molecular states. We then calculate the three-body binding energy using the NLEFT and analyze the systematic uncertainties due to the finite volume effects, the sliding cutoff, and the leading-order three-body forces. Even when the three-body interaction is repulsive (even as large as the infinite repulsive interaction), the three-body system has a bound state unambiguously with binding energy no larger than the Ds1(2460)D threshold. To check the renormalization group invariance of our framework, we extract the first excited state. We find that when the ground state is fixed, the first excited states with various cutoffs coincide with each other when the cubic size goes larger. In addition, the standard angular momentum and parity projection technique is implemented for the quantum numbers of the ground and excited states. We find that both of them are S-wave states with quantum number JP=1−. Because the three-body state contains two charm quarks, it is easier to be detected in the Large Hadron Collider.

Published by the American Physical Society
2025
Corporate governance and foreign direct investment in Latin America
Authors: Lombana-Coy Jahir , Salcedo Nestor U. 
Published: February 2025

Purpose
Hitherto, several Latin American countries have pinned their hopes for growth in international markets through foreign direct investments (FDIs). However, much investor confidence is shaped by perceptions of the country’s corporate governance pillars, such as accountability, board efficacy and investor protection. Thus, this study aims to examine how these corporate governance pillars impact on FDI inflows among the countries in this region.

Design/methodology/approach
The research design is a causal longitudinal non-experimental empirical study that uses the gravity model of the FDI bilateral flow from 17 Latin American countries from 10 years before COVID-19, obtained from 272 bilateral flows and 2,992 observations. The authors factorized and normalized country-level corporate governance measures from the World Bank and generated the dynamic panel data estimates with the Arellano–Bond two-step generalized method of moments system.

Findings
The findings of this study are robust concerning previous gravity models, showing that FDI bilateral flows depend significantly on their lagged flows and the economic growth of the reporter countries. This study shows accountability and board efficacy significantly increase FDI bilateral flows in Latin America. Investor protection only positively influences the FDI bilateral flow if it is from the home country.

Originality/value
The literature on the relationship between FDI and corporate governance is relatively scarce to justify such pillars of corporate governance in Latin America from the perspective of bilateral investment flows. Thus, this study seeks precisely to deepen the analysis of the relationship between FDI flows and corporate governance. Additionally, the authors present theoretical and policy implications with a future research agenda.
Microlearning in organizations: patterns and future directions
Authors: Kumar V.V. Ravi , Sen Sujoy 
Published: February 2025

Purpose
This study investigates the patterns in Microlearning by analyzing the extant literature, uncovering the underlying themes, and proposing future directions in this field for organizations.

Design/methodology/approach
A relevant search of the Scopus database was performed on 4th August 2024 which revealed a total of 108 articles. These articles were then analyzed and a network analysis was performed using VOSViewer to uncover the research themes and clusters. Articles pertaining to the domain of Business Management were included for the study.

Findings
The findings are based on the published literature from Scopus database and generating an intellectual structure through VOSviewer. Four underlying themes projecting the patterns associated with Microlearning were revealed and future directions based on these patterns were suggested.

Research limitations/implications
This study is a window to the immense possibility of future research in the emerging field of Microlearning. Researchers can conduct empirical studies related to Microlearning with reference to each of the four clusters that emerged from the study. The future directions suggested in the study may also be validated through quantitative research.

Practical implications
Organizations can utilize this study to understand and incorporate Microlearning and base their organizational policies to evolve into inclusive learning organizations.

Social implications
Microlearning can prove to be a great learning technique to promote gender-agnostic inclusive learning catering to different learning styles.

Originality/value
This paper is a unique study that uncovers the patterns and indicates the future directions in Microlearning – an evolving learning technique appealing to a diverse set of learners.
Developing a Green-BIM team to improve the construction of green buildings in Sri Lanka
Authors: Rupasinghe Chathushka , Ranadewa K.A.T.O. , Jayanetti J.K.D.D.T. , Perera B.A.K.S. 
Published: February 2025

Purpose The purpose of the paper is to propose a novel Green-BIM team (GBT) through a framework that would be essential in mitigating barriers to Green-BIM integration.Design/methodology/approach An interpretive stance is adopted for this study. Through a qualitative survey, 25 experts with proficiency in green building construction and building information modelling (BIM) implementation were interviewed. Code-based content analysis was carried out using NVivo12.Findings The findings of this study signified the need for a GBT and proposed architect, client, Green consultant, designer (mechanical, electrical and plumbing [MEP], structural), BIM coordinator, engineer (MEP, structural), project manager, quantity surveyor and facilities manager to be involved in the team representing design phase, construction phase and operational phase.Research limitations/implications The experts were limited to the Sri Lankan context; however, the findings can also benefit countries with socio-economic and cultural backgrounds similar to Sri Lanka.Practical implications Findings will be beneficial for policymakers and industry professionals to promote a BIM-enabled green building environment. The proposed GBT model extends existing theoretical frameworks, emphasising the need for a multi-disciplinary team throughout the entire lifecycle of a green building.Social implications The proposed GBT model aligns with broader societal goals related to sustainable development. This approach provides a sustainable pathway to achieve economic goals for all stakeholders in the construction sector.Originality/value There is a dearth of literature on a GBT to improve the construction of green buildings in Sri Lanka. Thus, the developed model is unique as it presents a novel GBT for the Sri Lankan construction sector. Further, it elaborates roles and responsibilities of team members with comprehensive details on how to mitigate the barriers to Green-BIM integration.
The role of adhocracy culture in open innovation in SMEs
Authors: Shahin Mohammad Muein Rasheed , Chong Chin Wei , Ojo Adedapo O. 
Published: February 2025

Purpose
Studies have demonstrated the role of organizational culture on innovative performance. However, there is limited focus on the role of adhocracy culture in facilitating open innovation in organizations, especially in small and medium enterprises (SMEs) that are constrained by a lack of adequate resources, making them dependent on dynamic innovative culture such as adhocracy culture.

Design/methodology/approach
This study used a quantitative methodology, using both exploratory and descriptive methods. Five hundred manufacturing SMEs in Jordan were chosen through systemic random sampling from a registered list of 2,310 manufacturing SMEs. A questionnaire was used as the study’s instrument on these SMEs. In sum, 335 responses (67%) were considered suitable for analysis.

Findings
This paper supports the previous studies that suggest that the success of open innovation rests largely on creating an effective organizational culture (e.g., adhocracy culture). However, this paper indicates the positive influence of adhocracy culture on the features of open innovation (i.e., inbound innovation, outbound innovation).

Originality/value
This study contributes to the literature by emphasizing the organizational elements that encourage open innovation in SMEs. It also provides empirical knowledge of a research model that offers SME stakeholders a cost-effective driver for open innovation activities by transforming intangible resources such as organizational culture, namely, adhocracy culture, to boost the competitiveness of their SMEs.
Investigation of temperature jump, first and second-order velocity slip effects on blood-based ternary nanofluid flow in convergent/divergent channels
Authors: Gunay Tunahan , Erdem Duygu , Sahin Ahmet Ziyaettin 
Published: February 2025

Purpose
High surface area-to-volume ratios make nanoparticles ideal for cancer heat therapy and targeted medication delivery. Moreover, ternary nanofluids (TNFs) may possess superior thermophysical properties compared to mono- and hybrid nanofluids due to their synergistic effects. In light of this information, the objective of this article is to examine the blood-based TNF flow within convergent/divergent channels under velocity slip and temperature jump.

Design/methodology/approach
Leading partial differential equations corresponding to the problem are transformed into a system of nonlinear ordinary differential equations by using similarity variables. The bvp4c code that uses the finite difference method is used to obtain a numerical solution.

Findings
The effect of nanoparticles may change depending on the characteristics of flow near the wall. The properties and proportions of the used nanoparticles become important to control the flow. When TNF was used, an increase in the Nusselt number between 4.75% and 6.10% was observed at low Reynolds numbers. At high Reynolds numbers, nanoparticles reduce the Nusselt number and skin friction coefficient values under some special flow conditions. Importantly, the effects of second-order slip on engineering parameters were also investigated. Furthermore, the Nusselt number increases with increasing shape factor.

Research limitations/implications
Obtained results of the study can be beneficial in both nature and engineering, especially blood flow in veins.

Originality/value
The main innovations of this study are the usage of blood-based TNF and the examination of the effect of shape factor in convergent/divergent channels with second-order velocity slip.
Integrating poetry as a pedagogical and therapeutic tool: evidence from a Bangladeshi classroom
Authors: Tareq Abu Musa Md. , Alam Md. Bayezid 
Published: February 2025

PurposeThis study looks at how poetry affects students’ emotional well-being, assesses its potential as a therapeutic tool and explores how poetry can enhance students’ participation and engagement in a Bangladeshi classroom.Design/methodology/approachA qualitative case study approach was used. Data sources included six semi-structured interviews and four non-participant classroom observations. All data were analyzed thematically.FindingsThe poetry had a profound impact on the students’ emotional states by providing a space for them to express feelings, explore emotions and accelerate personal growth. Poetry evoked passion, reflected their lives and affected them emotionally. It assisted students in becoming more resilient and better able to control their emotions. Furthermore, poetry in the classroom enhanced students’ attentiveness, interactions and participation by making the learning process more interactive and emotionally engaging.Originality/valueThe study offers valuable insights on incorporating poetry in teaching practices to improve students’ emotional well-being and fosters more engaging and meaningful learning experiences.
The impact of financial development and regulation on technology gaps and cost efficiency in banks: a cross-country analysis
Authors: Seelanatha Senarath Lalithananda , Natoli Riccardo 
Published: February 2025

Purpose
This study aims to examine the effects of financial development and banking regulation on technology gaps and cost efficiency in banks, controlling for bank- and country-specific factors.

Design/methodology/approach
A stochastic frontier analysis is used to empirically investigate the cost efficiency of 277 banks in 11 Asia-Pacific countries from 2011 to 2019. To compare their banking sectors, 11 countries are categorized as high- or low-income.

Findings
The results show that the level of financial development is key to the technology type adopted by banks in low-income countries, but the regulatory environment is more important to technology gaps and cost efficiency in high-income countries.

Research limitations/implications
A limitation of this study relates to data availability: some firms were excluded through the application of limiting criteria. The research has implications for bank regulators in high-income countries and demonstrates the need for further investigation of the financial development of banks in low-income countries.

Originality/value
This study applies the most recent meta-frontier technique to a sample of banks in the Asia-Pacific region to identify determinants of bank cost efficiency and technology gaps.