bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trials
Authors: ElKhalifa Dana , Al-Ziftawi Nour , Awaisu Ahmed , Alali Feras , Khalil Ashraf 
Published: November 2023

ObjectivesThis paper presents a systematic review aimed at assessing the therapeutic potential of sulforaphane (SFN) in the treatment of diverse cancer types.MethodsFollowing Cochrane guidelines for systematic reviews, we conducted an exhaustive search of electronic databases up to May 12, 2023, encompassing PubMed, Cochrane, Embase, Web of Science, Google Scholar, Natural Medicines, ProQuest, ClinicalTrials.gov, and ICTRP. Studies were included if they were human-based RCTs involving cancer patients where SFN was the primary experimental treatment. The Cochrane Risk of Bias tool for RCTs (RoB2) was used for quality assessment.ResultsEight studies investigating the efficacy and safety of SFN in prostate cancer (PCa), breast cancer, pancreatic cancer, and melanoma were identified and included in the review. The dosing regimens were variable and inconsistent across the studies. SFN treatment led to statistically significant alterations in several vital genes and histological biomarkers across the studies. However, it did not impact some other key genes. Although not statistically significant, SFN improved overall survival in pancreatic cancer patients. The results on prostate-specific antigen (PSA) were inconsistent in PCa. None of the studies reported significant differences between SFN and comparative controls in terms of adverse events.ConclusionSFN has emerged as a promising and safe therapeutic agent for diverse cancer types. Nevertheless, the high levels of methodological and clinical heterogeneity across the included studies precluded the possibility of conducting meta-analyses. Further robust clinical investigations to conclusively ascertain the chemotherapeutic potential of SFN in the management of various cancer forms are needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022323788, identifier CRD42022323788.
Animal-and mineral-based medicines in Gansu-Ningxia-inner Mongolia region, P.R. China: a cross-cultural ethnobiological assessment
Authors: Luo Chaoqun , Zhao Wenji , Liu Sha , Luo Mingxia , Fan Tingting , Zhao Yongxia , Ren Yan , Wu Faming , Xie Jian 
Published: November 2023

Introduction: Traditional animal- and mineral-based medicines are widely used in the Gansu-Ningxia-Inner Mongolia junction zone, a region with diverse ethnic groups and cultures. This study aims to document, conserve, and explore the potential of these medicines for further research and sustainable development of ethnic medicine.Methods: We interviewed 56 informants from different ethnic backgrounds and analyzed their responses quantitatively. Additionally, a comparative analysis with adjacent regions was conducted, providing invaluable contextual insights.Results: The study unveiled a diverse array of traditional medicines in the Gansu-Ningxia-Inner Mongolia junction zone. A total of 47 animal-based medicines were identified, ranging from insects and scorpios to distinctive animal organs. Of notable significance was Moschus, emerging as a pivotal traditional Chinese medicine resource. In parallel, 12 mineral-based medicines were cataloged, procured both locally and from “pharmacies”. Female informants, frequently local herbal practitioners, demonstrated broader knowledge of medicines. The analysis of 13 villages revealed varying perceptions of medicine importance, underscoring the wealth of traditional knowledge. Specific medicines, such as Feng-Mi and Xie-Zi, were widely used and valued in local healthcare practices for their cultural and medicinal benefits.Conclusion: This study provides a comprehensive overview of traditional animal- and mineral-based medicines in the Gansu-Ningxia-Inner Mongolia junction zone. It highlights the need for preserving and applying these practices in a sustainable manner. It also lays a solid foundation for future research on ethnic medicine, which can contribute to the holistic wellbeing of local communities.
Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists
Authors: Płoszczyca Kamila , Czuba Miłosz , Chalimoniuk Małgorzata , Witek Konrad , Baranowski Marcin 
Published: November 2023

Purpose: The effectiveness of altitude training on haematological adaptations is largely dependent on iron metabolism. Hepcidin and erythroferrone (ERFE) are key iron-regulating hormones, yet their response to altitude training is poorly understood. The aim of this study was to analyze changes in hepcidin and ERFE under the influence of 3 weeks of the Live High-Train Low (LH-TL) method.Methods: Twenty male trained cyclists completed a 3-week training program under normoxic conditions (NORM) or with passive exposure to normobaric hypoxia (LH-TL; FiO2 = 16.5%, ∼2000 m; 11–12 h/day). Hepcidin, ERFE, hypoxia inducible factor-2 (HIF-2), ferroportin (Fpn), erythropoietin (EPO), serum iron (Fe) and hematological variables were assessed at baseline (S1), then immediately after (S2) and 3 days after (S3) intervention.Results: In the LH-TL group, hepcidin decreased by 13.0% (p &lt; 0.001) in S2 and remained at a reduced level in S3. ERFE decreased by 28.7% (p &lt; 0.05) in S2 and returned to baseline in S3. HIF-2α decreased gradually, being lower by 25.3% (p &lt; 0.05) in S3. Fpn decreased between S1 and S2 by 18.9% (p &lt; 0.01) and remained lower during S3 (p &lt; 0.01). In the NORM group, in turn, hepcidin levels increased gradually, being higher by 73.9% (p &lt; 0.05) in S3 compared to S1. No statistically significant differences in EPO were observed in both groups.Conclusion: Three weeks of LH-TL suppresses resting hepcidin and ERFE levels in endurance athletes. We found no association between hepcidin and ERFE after LH-TL. Probably, ERFE is not the only factor that suppresses hepcidin expression in response to moderate hypoxia, especially in later stages of hepcidin downregulation. With the cessation of hypoxia, favorable conditions for increasing the availability of iron cease.
Leaders’ induced justice perceptions as mediator of the relation between participative leadership behaviors and team learning
Authors: Raineri Andres 
Published: November 2023

IntroductionIn today’s complex and changing business environment organizations need to learn and adapt to emerging circumstances. Teams can be a preferred vehicle to facilitate solving challenges that require diverse perspectives and expertise, collaboration, and knowledge sharing among members. To support team learning, organizations need to understand and promote an appropriate environment that facilitates learning within teams. By drawing on Fairness Theory and Social Exchange Theory, this study explores the role of leader-induced justice perceptions as a mediator in the relationship of participative leadership and team learning.MethodsUsing a split-half team survey methodology with a sample of 211 teams, the study analyzes the role of team justice climate as a mediation mechanism in the relationship between participative leadership behaviors and team learning.ResultsResults from structural equation modeling analyses suggest that, at a team level, participative leadership behaviors have both a direct association with team learning and are partially mediated by the team’s justice climate.DiscussionThis study contributes to existing literature by offering evidence that the perceptions of justice instilled by leaders play a role mediating participatory leadership and team learning. Moreover, the study supports the idea that leader induced justice perceptions can be considered as an aggregated construct at the team level. From a practical standpoint, the findings imply that team leaders can contribute to create an environment conducive to team learning by treating team members with fairness.
Hatha yoga is more effective in improving kinesiophobia and subjective well-being when combined with self-compassion meditation in people with CLBP: a randomized control trial
Authors: De Giorgio Andrea , Angilletta Sonia , Matteo Barbara , Bonavolontà Valerio , Bragazzi Nicola Luigi , Kuvačić Goran 
Published: November 2023

ObjectiveThe present study aims to examine whether combining hatha yoga practice with self-compassion meditation could influence kinesiophobia, emotions, perceived stress, and perceived disability among individuals with chronic low back pain when compared with hatha yoga alone.MethodsThe randomized controlled study included 70 participants with chronic low back pain (CLBP) who were randomly assigned to a Hatha yoga group (HY; n = 35) or a Hatha yoga group plus self-compassion meditation (HYSCM; n = 35). Participants followed a protocol for 8 weeks, and the assessments were carried out before and after the intervention, with a follow-up evaluation conducted after one month. The participants completed the PANAS, PSS, TSK, and RMQ questionnaires. A Generalized Estimating Equation was used to explore the effect of interventions.ResultsBoth HY and HYSCM groups improved kinesiophobia, perceived disability, and stress at the follow-up. However, the HYSCM group shown a more significant reduction in kinesiophobia compared to the HY group. Moreover, significant improvement in positive affect and a reduction in negative affect over time in the HYSCM group were observed.ConclusionHatha yoga practice when combined with self-compassion meditation led to extra benefits by exhibiting a prolonged effect, especially on kinesiophobia positive and negative effects.
Neurocognitive and adaptive phenotypes in adolescent inpatients with mood disorders: an exploratory study on disruptive mood dysregulation disorder in the framework of depressive disorders
Authors: Apicella Massimo , Pisa Marcella Caterina , Averna Roberto , Labonia Milena , Pontillo Maria , Vicari Stefano 
Published: November 2023

IntroductionFew studies on adolescents have investigated intelligence quotient (IQ) in mood disorders. Evidence on Disruptive Mood Dysregulation Disorder (DMDD), a controversial entity among depressive disorders, is more limited.Materials and methodsWe performed an exploratory study on adolescent inpatients with unipolar mood disorders to test specific impairment in cognitive and adaptive profile. We also considered common psychopathological comorbidities. We retrospectively collected data on inpatients with a diagnosis of major depressive disorder (MDD), DMDD or Depressive Disorder – Not Otherwise Specified (DD-NOS) evaluated with Wechsler Scales of Intelligence, Adaptive Behavior Assessment System (ABAS-II), and Children’s Global Assessment Scale (C-GAS).ResultsOut of 198 inpatients (85.9% females), 33.3% had MDD, 60.1% DD-NOS and 6.6% DMDD. DMDD patients had higher rates of ADHD (15.4%) and learning disorders (LD, 23.1%), a lower mean IQ (87.8 ± 10.7; p = 0.001) and ABAS-II scores (general composite 68.8 ± 16.8; p = 0.002) than other groups. In linear regression analysis, DMDD retained a significant correlation with lower IQ and adaptive abilities when controlling for sex, and comorbidities. Among comorbidities, LD correlated with lower perceptual reasoning and IQ, and ADHD with lower conceptual adaptive abilities. In all diagnosis groups, working memory and processing speed were lower than verbal comprehension and perceptual reasoning.DiscussionWhile impairment in working memory and processing speed is a non-specific correlate of active mood disorder, DMDD is burdened by lower general intelligence and adaptive abilities and higher rate of neurodevelopmental comorbidities. Lower IQ in the normal range is a correlate of DMDD among variables examined, not explained by the effect of neurodevelopmental comorbidities. These findings are discussed with regards to possible implications for the consideration of DMDD as a bridge condition between neurodevelopmental disorders and mood disorders.
Positive and negative viral associations in patients with acute respiratory tract infections in primary care: the ECOVIR study
Authors: Petat Hortense , Schuers Matthieu , Marguet Christophe , Humbert Xavier , Le Bas François , Rabiaza Andry , Corbet Sandrine , Leterrier Bryce , Vabret Astrid , Ar Gouilh Meriadeg 
Published: November 2023

IntroductionAcute respiratory infections (ARIs) are the most common viral infections encountered in primary care settings. The identification of causal viruses is still not available in routine practice. Although new strategies of prevention are being identified, knowledge of the relationships between respiratory viruses remains limited.Materials and methodsECOVIR was a multicentric prospective study in primary care, which took place during two pre-pandemic seasons (2018–2019 and 2019–2020). Patients presenting to their General practitioner (GP) with ARIs were included, without selecting for age or clinical conditions. Viruses were detected on nasal swab samples using a multiplex Polymerase Chain Reaction test focused on 17 viruses [Respiratory Syncytial Virus-A (RSV-A), RSV-B, Rhinovirus/Enterovirus (HRV), human Metapneumovirus (hMPV), Adenovirus (ADV), Coronaviruses (CoV) HKU1, NL63, 229E, OC43, Influenza virus (H1 and H3 subtypes), Influenza virus B, Para-Influenza viruses (PIVs) 1–4, and Bocavirus (BoV)].ResultsAmong the 668 analyzed samples, 66% were positive for at least one virus, of which 7.9% were viral codetections. The viral detection was negatively associated with the age of patients. BoV, ADV, and HRV occurred more significantly in younger patients than the other viruses (p &lt; 0.05). Codetections were significantly associated with RSV, HRV, BoV, hMPV, and ADV and not associated with influenza viruses, CoV, and PIVs. HRV and influenza viruses were negatively associated with all the viruses. Conversely, a positive association was found between ADV and BoV and between PIVs and BoV.ConclusionOur study provides additional information on the relationships between respiratory viruses, which remains limited in primary care.
Epidemiology of vancomycin-resistant enterococci in the United Arab Emirates: a retrospective analysis of 12 years of national AMR surveillance data
Authors: Thomsen Jens , Abdulrazzak Najiba M. , AlRand Hussain ,   The UAE AMR Surveillance Consortium, Menezes Godfred Antony , Moubareck Carole A. , Everett Dean B. , Senok Abiola , Podbielski Andreas 
Published: November 2023

IntroductionEnterococci are usually low pathogenic, but can cause invasive disease under certain circumstances, including urinary tract infections, bacteremia, endocarditis, and meningitis, and are associated with peritonitis and intra-abdominal abscesses. Increasing resistance of enterococci to glycopeptides and fluoroquinolones, and high-level resistance to aminoglycosides is a concern. National antimicrobial resistance (AMR) surveillance data for enterococci from the Middle East and North Africa (MENA) and the Gulf region is scarce.MethodsA retrospective 12-year analysis of N = 37,909 non-duplicate diagnostic Enterococcus spp. isolates from the United Arab Emirates (UAE) was conducted. Data was generated by routine patient care during 2010–2021, collected by trained personnel and reported by participating surveillance sites to the UAE National AMR Surveillance program. Data analysis was conducted with WHONET.ResultsEnterococcus faecalis was the most commonly reported species (81.5%), followed by Enterococcus faecium (8.5%), and other enterococci species (4.8%). Phenotypically vancomycin-resistant enterococci (VRE) were found in 1.8% of Enterococcus spp. isolates. Prevalence of VRE (%VRE) was highest for E. faecium (8.1%), followed by E. faecalis (0.9%). A significant level of resistance to glycopeptides (%VRE) for these two species has been observed in the majority of observed years [E. faecalis (0–2.2%), 2010: 0%, 2021: 0.6%] and E. faecium (0–14.2%, 2010: 0%, 2021: 5.8%). Resistance to fluoroquinolones was between 17 and 29% (E. faecalis) and was higher for E. faecium (between 42 and 83%). VRE were associated with higher patient mortality (RR: 2.97), admission to intensive care units (RR: 2.25), and increased length of stay (six excess inpatient days per VRE case), as compared to vancomycin-susceptible Enterococcus spp.DiscussionPublished data on Enterococcus infections, in particular VRE-infections, in the UAE and MENA region is scarce. Our data demonstrates that VRE-enterococci are relatively rare in the UAE, however showing an increasing resistance trend for several clinically important antibiotic classes, causing a concern for the treatment of serious infections caused by enterococci. This study also demonstrates that VRE were associated with higher mortality, increased intensive care unit admission rates, and longer hospitalization, thus poorer clinical outcome and higher associated costs in the UAE. We recommend the expansion of current surveillance techniques (e.g., local VRE screening), stricter infection prevention and control strategies, and better stewardship interventions. Further studies on the molecular epidemiology of enterococci are needed.
Unraveling the link between hypertension and depression in older adults: a meta-analysis
Authors: Gan Qingwen , Yu Ran , Lian Zerong , Yuan Yiling , Li Yuanping , Zheng Lilan 
Published: November 2023

ObjectiveTo perform a meta-analyses to understand the current status of and risk factors for depression in older adults with hypertension.MethodsEight electronic databases and two clinical trial registries were searched to identify studies examining the incidence of and risk factors for depression among older adults with hypertension. The databases were searched from inception to June 2023. The included studies were evaluated using the Newcastle–Ottawa scale and the evaluation tool recommended by the Agency for Health care Research and Quality.ResultsA total of 18 studies with 29,694 patients were included. Meta-analysis results showed that the prevalence of depression in older adults with hypertension was 29%. The risk factors for depression among this population included sex [OR value 95% confidence interval 2.24 (1.32, 3.82)], education level [OR 95% CI 1.79 (1.02, 3.14)], residence [OR 95% CI 1.37 (1.24, 1.52)], comorbidities [OR 95% CI 1.79 (1.69, 1.90)], hypertension classification [OR 95% CI 2.81 (1.79, 4.42)], marital status [OR 95% CI 1.50 (1.33, 1.69)], sleep status [OR 95% CI 2.86 (2.21, 3.69)], activity limitation [OR 95% CI 3.42 (2.84, 4.13)], drinking [OR 95% CI 2.25 (1.58, 3.19)], social support [OR 95% CI 3.26 (2.42, 4.41)], living alone [OR 95% CI 1.79 (1.57, 2.04)], stressful events [OR 95% CI 1.62 (1.39, 1.90)], and course of diseases [OR 95% CI 3.23 (2.10, 4.97)].ConclusionThe incidence of depression in older adults with hypertension is high, and there are many risk factors. Clinical health care professionals should intervene early to target the above risk factors to reduce the incidence of depression in older adults with hypertension worldwide.Systematic review registrationPROSPERO (york.ac.uk), identifier [CRD42023417106].
The high energy X-ray probe (HEX-P): studying extreme accretion with ultraluminous X-ray sources
Authors: Bachetti Matteo , Middleton Matthew J. , Pinto Ciro , Gúrpide Andrés , Walton Dominic J. , Brightman Murray , Lehmer Bret , Roberts Timothy P. , Vasilopoulos Georgios , Alford Jason , Amato Roberta , Ambrosi Elena , Dai Lixin , Earnshaw Hannah P. , El Byad Hamza , García Javier A. , Luca Israel Gian , Jaodand Amruta , Madsen Kristin , Maitra Chandreyee , Mandel Shifra , Mori Kaya , Pintore Fabio , Ohsuga Ken , Pilia Maura , Stern Daniel , Younes George , Wolter Anna 
Published: November 2023

Introduction: Ultraluminous X-ray sources (ULXs) represent an extreme class of accreting compact objects: from the identification of some of the accretors as neutron stars to the detection of powerful winds travelling at 0.1–0.2 c, the increasing evidence points towards ULXs harbouring stellar-mass compact objects undergoing highly super-Eddington accretion. Measuring their intrinsic properties, such as the accretion rate onto the compact object, the outflow rate, the masses of accretor/companion-hence their progenitors, lifetimes, and future evolution-is challenging due to ULXs being mostly extragalactic and in crowded fields. Yet ULXs represent our best opportunity to understand super-Eddington accretion physics and the paths through binary evolution to eventual double compact object binaries and gravitational-wave sources. Methods: Through a combination of end-to-end and single-source simulations, we investigate the ability of HEX-P to study ULXs in the context of their host galaxies and compare it to XMM-Newton and NuSTAR, the current instruments with the most similar capabilities.Results: HEX-P’s higher sensitivity, which is driven by its narrow point-spread function and low background, allows it to detect pulsations and broad spectral features from ULXs better than XMM-Newton and NuSTAR.Discussion: We describe the value of HEX-P in understanding ULXs and their associated key physics, through a combination of broadband sensitivity, timing resolution, and angular resolution, which make the mission ideal for pulsation detection and low-background, broadband spectral studies.
Miniaturization and Bandwidth Enhancement of Fractal-Structured Two-Arm Sinuous Antenna Using Gap Loading with Meandering
Authors: Kim Junghyeon , Keun Jongho , Yoo Taehoon , Lim Sungjoon 
Published: November 2023

A sinuous antenna is a frequency-independent antenna known for its wide bandwidth and consistent gain, which makes it valuable in broadband applications such as ultrawideband (UWB) radar and ground-penetrating radar (GPR). However, sinuous antennas tend to be rather large. Consequently, numerous studies have explored miniaturization methods, with the gap-loading method emerging as a prominent approach. Unfortunately, it is still difficult to achieve broad bandwidths for conventional miniaturized sinuous antennas. In this paper, we use a novel approach incorporating a meander shape into the sinuous curve and employing gap loading with meandering. This innovative technique results in the development of a fractal-structured two-arm sinuous antenna characterized by an ultra-compact size and significantly expanded bandwidth. Adding a meander line in the outermost part maximizes the capacitance, thereby enhancing the gap-loading effect and minimizing the overall size of the sinuous antenna. In addition, the introduction of an inner meander line increases the inductance, contributing to a further expansion of the antenna’s bandwidth. For example, the electrical length of the antenna without the meander line is 0.552 × 0.552 × 0.052 λg3, while the electrical length of the antenna with the meander line is only 0.445 × 0.445 × 0.036 λg3, i.e., 19.4% smaller. The antenna lacking the outermost meander line exhibits a 10 dB impedance bandwidth, spanning from 0.74 to 10.53 GHz. In contrast, the antenna featuring the outermost meander line has a 10 dB impedance bandwidth, extending from 0.51 to 10.72 GHz, which results in a remarkable enhancement in the fractional bandwidth (by 8.1%). Hence, the proposed antenna design is a good candidate for broadband applications that require miniaturization.
Origen y evolución de la educación emocional
Authors: Machado Pérez Yumary 
Published: November 2023

En la actualidad la educación emocional se ha convertido en uno de los grandes desafíos de la escuela del siglo XXI, ya que esta debe educar a los estudiantes tanto en lo académico como en lo emocional. La educación emocional tiene sus orígenes en las diferentes teorías de inteligencia emocional. El presente artículo tiene como objetivo sistematizar el origen y la evaluación de la educación emocional, para ello se desarrolló una síntesis y análisis de diferentes teorías de inteligencia emocional considerando los autores Salovey y Mayer, Bar-On, Goleman, Bisquerra y Fernández-Berrocal y Extremera. Lo que permitió conocer la evolución y el estado actual de las teorías de inteligencia emocional y su vinculación y aplicabilidad en el ámbito educativo. Para ello se trabajó con la metodología de investigación documental siguiendo el método hermenéutico.