bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS TEST OF WOUND PATCH PREPARATIONS OF GOTU KOLA LEAF EXTRACT (Centella asiatica (L.) Urb.) ON INCISION WOUND IN RABBITS
Authors: Marini Marini , Azizah Nur , Rohman Devin Nur , Diputra Angga Anugra 
Published: December 2023

A wound patch is a dosage form that delivers drugs through the skin to produce systemic effects, with the advantage of controlled drug release. Centella asiatica (L.) Urb.) is widely used to heal incision wounds on the skin. The most important component was asiaticoside, which plays a major role in accelerating wound healing. This study was conducted to test the effectiveness of transdermal patches from Centella asiatica (L.) Urb.) against incision wounds was performed on 5 rabbits divided into different treatment groups, namely group I without treatment, group II wound patch base (negative control), group III plaster (positive control), and groups IV and V, comprising a wound patch of gotu kola leaf extract at concentrations of 16% and 32%, respectively. The data obtained were statistically tested for normality using the Shapiro-Wilk test. The results showed that the wound patch preparation of 16% gotu kola leaf extract showed a significant difference (p < 0.05) in wound length reduction compared to the negative and normal controls. The wound healing time observed at concentrations of 16% and 32% provided wound healing effects. The best effect was observed at a concentration of 16%, with an average wound closure time of 12 days. It can be concluded that gotu kola leaf extract in the form of a wound patch preparation was effective in wound healing.
Keywords: Gotu kola leaf extract; incision wound; Wound patch; Effectiveness test
Solar Observations by Angelo Secchi. I. Digitization of Original Documents and Analysis of Group Numbers over the Period of 1853–1878
Authors: Ermolli I. , Chatzistergos T. , Giorgi F. , Carrasco V. M. S. , Aparicio A. J. P. , Chinnici I. 
Published: December 2023

Abstract
Angelo Secchi, an Italian Jesuit and prominent scientist of the 19th century, and one of the founders of modern astrophysics, observed the Sun regularly at the Collegio Romano in Rome, Italy, for more than 25 yr. Results from his observations are reported in articles published in the scientific journals of the time, as well as in drawings and personal notebooks that are stored in the historical archive of the Istituto Nazionale di Astrofisica Osservatorio Astronomico di Roma. The latter material, which reports solar observations performed from 1853–1878, includes original documents from Secchi and from a few of his close collaborators. The above unique material has recently been digitized for preservation purposes and for allowing the scientific exploitation of data not easily accessible so far. A total of more than 5400 digital images have been produced. Here we present the archival material and the new digital data derived from it. We also present results obtained from our primary analysis of the new digital data. In particular, we produced new measurements of the group number from 1853–1878, which will be available for future recalibration of the group number series.
Comment se font les administrations municipales de la sécurité
Authors: Freyermuth Audrey 
Published: December 2023

En étudiant la naissance et les réorganisations des administrations municipales dédiées à la sécurité entre 1995 et 2020 à Lyon, Nice, Rennes et Strasbourg, nous montrons comment les dynamiques du jeu politique local favorisent la disqualification et la consécration de savoir-faire et d’expertises qui, en retour, contribuent à la technicisation et à l’institutionnalisation de la sécurité dans le cadre municipal. Si les recompositions politiques contribuent à une reconfiguration des administrations locales par la création de services et de rôles spécifiquement dédiés à la sécurité et à la tranquillité publiques, les dynamiques du jeu politique local orientent également le recrutement des responsables de ces services. À travers la comparaison des trajectoires et des ressources professionnelles des agents retenus ou gardés à distance de l’administration municipale, l’article montre que la sélection de ces nouveaux professionnels de la sécurité dont les profils sont très hétérogènes, est dépendante des rapports de force politiques locaux. Plus particulièrement, la disqualification singulière des savoir-faire policiers à Rennes apparaît comme un levier de mise en conformité politique de la sécurité qui rend possible son institutionnalisation.
Végétarisme et transmission culinaire en France et en Corée du Sud. Comment une nouvelle pratique alimentaire impacte la transmission ?
Authors: Yun Heejin 
Published: December 2023

La transmission d’un savoir-faire culinaire est un processus complexe parce que changeant selon les lieux et les sociétés. Autrement dit, elle peut être influencée par de nouveaux modes de vie qui impactent l’alimentation, comme le végétarisme, le régime sans gluten et le locavorisme (la consommation de produits locaux), etc. Elle peut l’être par l’adoption de concepts philosophiques, de nouvelles visions du monde que créent par exemple actuellement le réchauffement climatique ou la crise sanitaire. En France et en Corée du Sud, la population végétarienne connaît une augmentation et le régime végétarien est souvent vu comme une pratique « urbaine ». Ce travail de recherche s’appuie sur les enquêtes qualitatives auprès des Parisiens et des Séouliens qui suivent le végétarisme, encore pratiqué par une minorité. Il est intéressant de voir dans quelle mesure ce régime alimentaire végétarien coexiste avec les pratiques traditionnelles de transmission des cuisines française et sud-coréenne, voire les menace, et comment il est transmis.
Le métissage en Sibérie au xix e siècle, enjeux ethnographiques, sociaux et culturels
Authors: Bashkirov Mikhail 
Published: December 2023

Cette étude présente le processus de création de nouvelles communautés ethnoculturelles sur le territoire de la Sibérie par la colonisation russe et le métissage qui s’est ensuivi. Au cours des xvii e - xix e siècles, divers groupes d’origine mixte sont apparus dans différentes régions de Sibérie. Néanmoins, dans la tradition russe, aucun ethnonyme ou identité commune n’a émergé pour ces groupes, alors que le Métis existe au Canada. Bien que leur présence ait été documentée dans de nombreuses sources, y compris la fiction et l’ethnographie impériales, les métis sibériens sont restés dans une sorte de « zone grise » et n’ont pas bénéficié d’un statut colonial particulier. La seule exception est l’Amérique russe, c’est-à-dire les possessions russes en Amérique du Nord ou les métis avaient un statut spécial. Dans la plupart des sources, les groupes d’ascendance mixte se trouvent à la frontière entre la « civilisation » et la « sauvagerie ». En conséquence, les groupes métis étaient soit considérés comme trop « sauvages », ou « pas assez russes ». Mais un auteur a proposé une vision et des concepts spécifiques pour traiter de ces communautés. A. Shchapov a en effet compris le métissage comme un moyen d’intégrer les peuples autochtones dans l’espace impérial.
Common Knowledge in Game Theory
Authors: Ménager Lucie 
Published: December 2023

Lorsque tout le monde sait une chose, que tout le monde sait que tout le monde la sait, que tout le monde sait que tout le monde sait que tout le monde la sait et ainsi de suite, cette chose est dite connaissance commune. Aumann [1976] fut le premier à proposer une caractérisation formelle de la notion de connaissance commune dans l’article « Agreeing to Disagree ». Ce formalisme a soulevé un certain nombre de questions passionnantes. Peut-on expliquer les différences de comportements ou de croyances au sein d’un groupe par des asymétries d’information lorsque ces différences sont connaissance commune dans le groupe ? Des joueurs ont-ils besoin d’une forme de connaissance commune pour se coordonner sur un profil d’actions ? La communication permet-elle de faire émerger la connaissance commune au sein d’un groupe d’individus ? L’objectif de cet article est de passer en revue les travaux ayant proposé des réponses à ces questions.
Inflammasome Activation and IL-1β Release Triggered by Nanosecond Pulsed Electric Fields in Murine Innate Immune Cells and Skin
Authors: Mazzarda Flavia , Chittams-Miles Alexandra E , Pittaluga Julia , Sözer Esin B , Vernier P Thomas , Muratori Claudia 
Published: December 2023

Abstract
Although electric field–induced cell membrane permeabilization (electroporation) is used in a wide range of clinical applications from cancer therapy to cardiac ablation, the cellular- and molecular-level details of the processes that determine the success or failure of these treatments are poorly understood. Nanosecond pulsed electric field (nsPEF)–based tumor therapies are known to have an immune component, but whether and how immune cells sense the electroporative damage and respond to it have not been demonstrated. Damage- and pathogen-associated stresses drive inflammation via activation of cytosolic multiprotein platforms known as inflammasomes. The assembly of inflammasome complexes triggers caspase-1–dependent secretion of IL-1β and in many settings a form of cell death called pyroptosis. In this study we tested the hypothesis that the nsPEF damage is sensed intracellularly by the NLRP3 inflammasome. We found that 200-ns PEFs induced aggregation of the inflammasome adaptor protein ASC, activation of caspase-1, and triggered IL-1β release in multiple innate immune cell types (J774A.1 macrophages, bone marrow–derived macrophages, and dendritic cells) and in vivo in mouse skin. Efflux of potassium from the permeabilized cell plasma membrane was partially responsible for nsPEF-induced inflammasome activation. Based on results from experiments using both the NRLP3-specific inhibitor MCC950 and NLRP3 knockout cells, we propose that the damage created by nsPEFs generates a set of stimuli for the inflammasome and that more than one sensor can drive IL-1β release in response to electrical pulse stimulation. This study shows, to our knowledge, for the first time, that PEFs activate the inflammasome, suggesting that this pathway alarms the immune system after treatment.
One Health System Strengthening in India: Co-creating One Health Workforce to Combat Future Pandemics
Authors: Yasobant Sandul , Saxena Deepak , Bhardwaj Pankaj , Quazi Zahiruddin Syed 
Published: December 2023

Abstract
One Health has been coming of age through the G7 and G20 leadership and explicitly referred to in increasing ministerial declarations. Those leaderships, however, have been slow in knitting the One Health approach into the larger systems approach. by understanding the complexity of resilience and health system resilience is one of the key features of pandemic preparedness. Among others, health system strengthening is another key factor that urgently requires much attention in the theme of pandemic preparedness. Here, how the health system strengthening requires more imperative attention in the One Health gambit is discussed in the Indian context.
“CoviSainik Program” – A Novel Public Private Partnership Initiative in the Control of COVID-19 in Rural India
Authors: Sabale Rupali , Velhal Gajanan , Sonawane Vinayak , Gupta Shilpi 
Published: December 2023

Abstract

Background:
“CoviSainik Program” was implemented in collaboration with the Ambuja Cement Foundation and Community Medicine Department in rural districts of eight states of India from May to December 2021 to create a cadre of volunteers. The aim of the present paper is to describe the program and evaluate it so that the findings can be the guiding tool for policymakers to replicate a similar program.

Material and Method:
A cross-sectional, mixed-method – concurrent study design was adopted to evaluate the program for its short-term outcomes such as gain in the basic knowledge of COVID-19 amongst master trainers and their feedback and program output viz – the proportion of volunteers trained and their profile by census sampling. Motivational factors, experiences of volunteers, and outcomes of COVID-19 work in their villages were explored by purposive with maximum diversity sampling with 62 online in-depth interviews and 8 online focus group discussions (FGDs).

Results:
There was a statistically significant difference in the pre-test (12.8 ± 5.6) and post-test (25.9 ± 9.3) scores of the Master Training Program evaluation test. Out of 6534 trained volunteers, 5901 worked as volunteers, and amongst those, 47.1%, 35.1%, and 17.8% worked for ≤3 months, 3 to 6 months, and ≥6 months, respectively, in their villages. The major themes generated for motivational factors to join the program were altruism, savior nature, generating awareness, and concern for others. The major outcomes generated by trained volunteers COVID-19 vaccination were in raising awareness on COVID-19 appropriate behavior and early identification of COVID-19 cases in their villages.

Conclusion:
The “CoviSainik Program” was successful in creating cadres of trained volunteers.
Mental Health Morbidities and their Correlates among the Adolescents in Kamrup (Metro), Assam: A School-Based Study
Authors: Saikia Anku M. , Das Hemen , Rajendran Vinoth 
Published: December 2023

Abstract

Background:
India has the largest adolescent population worldwide, and among this group, mental health issues account for 16% of the total global burden of disease and injury. Disturbingly, approximately half of these health conditions manifest before the age of 14 years. To assess the prevalence of depression, anxiety, and stress along with its correlates among the adolescents in the schools of Kamrup (Metro) district, Assam.

Methods and Material:
This cross-sectional study was conducted in 10 randomly selected high schools in the study area among the adolescents selected from 8th to 10th standards in the age group of 14 to 17 years. A pre-designed, pre-tested interview schedule, the modified Kuppuswamy scale, and ‘Depression Anxiety Stress Scale-21 Items’ (DASS 21) questionnaire were used for data collection.

Results:
The mean ± 2SD age of the adolescents was 14.74 ± 1.58 years. Among the adolescents, the overall prevalence of depression, anxiety, and stress was found to be 22.2%, 24.4%, and 6.9%, respectively.

Conclusions:
The occurrence of mental health morbidities among adolescents is notably widespread, yet researchers have largely overlooked this aspect. This underscores the need for comprehensive investigations into the factors that contribute to these mental health issues.
Prevalence of Asymptomatic Bacteriuria (ASB) in Pregnant Women in India: A Systematic Review and Meta-Analysis
Authors: Khapre Meenakshi , Sharma Divita , Mehta Aprajita , Sinha Smita 
Published: December 2023

Abstract

Background:
Asymptomatic bacteriuria is prevalent during pregnancy. If it goes undetected, it can lead to urinary tract infection with severe maternal and neonatal complications. Until date, India does not have any guidelines to test for ASB during pregnancy.

Objective:
To estimate the pooled prevalence of asymptomatic bacteriuria in pregnant women at national level in India.

Material and Methods:
We searched Medline, Embase, Web of Science, and Google Scholar using search strategy with keyword. Two authors independently assessed the eligibility of study. The checklist of the JBI was used for evaluating the quality of reporting. The extracted data were analyzed, and the results were reported using a random-effects model with 95% confidence interval (CI). Subgroup analysis was conducted for zones of India, parity and trimester. Publication bias is reported as funnel plot.

Result:
Pooled prevalence of asymptomatic bacteriuria among pregnant women in India is 13.5% [CI 11.1; 15.8]. Subgroup analysis based on the various geographic zones of the country the pooled prevalence ranged from 9.2% in central zone to 14.8% in south zone. Distribution of prevalence of ASB as per parity was approximately identical. The prevalence of ASB was found to be high in third (21.8%).

Conclusion:
The prevalence of ASB is found to be high among Indian pregnant women, especially in third trimester. It is therefore recommended for guideline to screen and treat every pregnant woman for ASB to prevent further complications.
Subsets of natural killer cells in chronic myeloid leukemia and their relation with some inflammatory cytokines
Authors: Faraj Yusur Falah , Salih Khalid Mahdi , Khelif Abderrahim , Hameed Elaf Zuhair 
Published: December 2023

BACKGROUND:
As in other malignancies, different subsets of natural killer (NK) cells play a crucial role in the recognition and lysing of malignant cells in chronic myeloid leukemia (CML).

OBJECTIVES:
This study aims to identify two subsets of NK, cytotoxic (cluster of differentiation [CD] 16+bright) and cytokine-producing NK (CD56+bright) in newly diagnosed CML patients.

MATERIALS AND METHODS:
This study is conducted on 20 newly diagnosed Iraqi patients (12 males and 8 females) with CML, in chronic phase, at the age range of 17–55 years. Along with patients, 20 healthy subjects (with matched age and gender) were enrolled to act as a control group. To identify NK cells and their subsets in peripheral blood samples, the expression of CD45, CD3, CD56, and CD16 markers was evaluated by flow cytometry technique. Furthermore, the serum level of interferon gamma (IFN-γ) and interleukin (IL)-18 was determined by the enzyme-linked immunosorbent assay technique.

RESULTS:
The age of patients at the diagnosis of disease is (35.6 ± 12.2 years) and the male: female ratio was 1.5:1. The serum level of IL-18 in newly diagnosed CML patients (30.3 ± 6.5 pg/mL) was significantly (P < 0.0001) higher than those in control group (18.3 ± 7.8 pg/mL), while the serum levels of IFN-γ in newly diagnosed patients are significantly (P = 0.006) dropped down to (89.1 ± 7.2 pg/mL from that in control group (109.4 ± 30.3 pg/mL). The percentage of NK cells in newly diagnosed CML patients is significantly lower than in control group. There is a significant elevation in the cytotoxic NK cells (CD16+bright) subset, and a significant decrease in the cytokine-producing NK subset (CD56+bright) in newly diagnosed patients when compared to those in control group.

CONCLUSION:
Although there is an elevation in the percentage of cytotoxic NK cells (CD16+bright) subset of CML patients at the first diagnosis, these cells are not able to recognize and attack malignant cells, which may be due to low expression of their activating receptors and needs more investigation. Furthermore, present results found a low percentage of cytokine-producing NK cells (CD56+bright) and a low level of IFN-γ in CML patients, although there is an elevation in IL-18, which indicates that IL-18 may be not the main stimulator to these cells, so activation pathway of this subset of NK cells needs further investigation.
The Problem with Capitalism in the Trichological Sciences
Authors: Trüeb Ralph Michel , Gadzhigoroeva Aida , Kopera Daisy , Luu Ngoc-Nhi Catharina , Dmitriev Angelina 
Published: December 2023

ABSTRACT
Karl Marx and Friedrich Engels exposed a pattern of societal conduct they chose to name capitalistic bourgeoisie. The bourgeoisie created a common language of communication through collaboration, gathered in circles such as free academies, scientific academies, literary circles, and the media, that provided forums for the emerging bourgeoisie to conceive of new social orders. One aspect of bourgeoisie culture is conspicuous consumption, central to which, is a culture of prestige through material consumption. Capitalism is an economic system based on private ownership and the operation for profit. Characteristic features of capitalism include competitive market, commercialism, property rights recognition, capital accumulation, material consumption, culture of prestige, sycophancy, and coterie. Critiques of capitalism allege that it is exploitative, alienating, unstable, unsustainable, and inefficient. In turn, critical theory inspired philosophers such as Michel Foucault to conceptualize how we form identities through social interaction. When the patient’s body entered the field of medicine, it also entered the field of power where the patient can be manipulated by professional authority. Without forcibly being a proponent of political theory, as an academic, one is inevitably confronted with Marxism in terms of philosophy. As a discipline at the interface of medicine, lifestyle, and cosmetics, trichology is particularly susceptible to the primary aims of profit, consumption, and prestige that characterize the capitalistic bourgeoisie. The trichological sciences, particularly trichoscopy, have discovered a profitable market for itself. The practice of trichology is not immune to malpractice. It has created an industry that dwells on the autistic thinking of patients and doctors, and because it is prosperous, makes propaganda among lay people and doctors that necessarily leads to abuses.
Association between Smartphone Addiction and Breathing Pattern in Sedentary Young College-Going Students – A Cross-Sectional Study
Authors: Shah IK , Kumar A , Rajasekar S , Pathak AA , Suvarna N , Gopal K , Muthukrishnan R 
Published: December 2023

ABSTRACT

Background:
The number of smartphone users has progressively increased worldwide. Altered biomechanics of the cervicothoracic spine and ribcage could limit the chest wall function that affects the respiratory muscles strength, reducing diaphragm function in smartphone users. This study aimed to compare breathing patterns between smartphone-addicted and -nonaddicted user groups.

Objective:
To find the association between excessive smartphone use and breathing pattern in sedentary young college-going students.

Materials and Methods:
This cross-sectional study includes 230 participants. The participants were screened for the inclusion and exclusion criteria and were asked to fill out a Smartphone Addiction Scale questionnaire. These breathing patterns were then assessed by self-evaluation of breathing questionnaire (SEBQ), manual assessment of respiratory motion (MARM), breath-holding test, and capnography.

Results:
The correlation of smartphone-addicted and -nonaddicted groups with breathing patterns was performed by Spearman rank correlation. Results show no significant association between the smartphone-nonaddicted and -addicted users.

Conclusion:
This study concluded that excessive smartphone use and breathing patterns are not associated.