bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asynchronous neural maturation predicts transition to psychosis
Authors: Iftimovici Anton , Bourgin Julie , Houenou Josselin , Gay Olivier , Grigis Antoine , Victor Julie , Chaumette Boris , Krebs Marie‐Odile , Duchesnay Edouard ,   for the ICAAR‐plus Study Group
Published: October 2023

AimNeuroimaging‐based machine‐learning predictions of psychosis onset rely on the hypothesis that structural brain anomalies may reflect the underlying pathophysiology. Yet, current predictors remain difficult to interpret in light of brain structure. Here, we combined an advanced interpretable supervised algorithm and a model of neuroanatomical age to identify the level of brain maturation of the regions most predictive of psychosis.MethodsWe used the voxel‐based morphometry of a healthy control dataset (N = 2024) and a prospective longitudinal UHR cohort (N = 82), of which 27 developed psychosis after one year. In UHR, psychosis was predicted at one year using Elastic‐Net‐Total‐Variation (Enet‐TV) penalties within a five‐fold cross‐validation, providing an interpretable map of distinct predictive regions. Using both the whole brain and each predictive region separately, a brain age predictor was then built and validated in 1605 controls, externally tested in 419 controls from an independent cohort, and applied in UHR. Brain age gaps were computed as the difference between chronological and predicted age, providing a proxy of whole‐brain and regional brain maturation.ResultsPsychosis prediction was performant with 80 ± 4% of area‐under‐curve and 69 ± 5% of balanced accuracy (P < 0.001), and mainly leveraged volumetric increases in the ventromedial prefrontal cortex and decreases in the left precentral gyrus and the right orbitofrontal cortex. These regions were predicted to have delayed and accelerated maturational patterns, respectively.ConclusionBy combining an interpretable supervised model of conversion to psychosis with a brain age predictor, we showed that inter‐regional asynchronous brain maturation underlines the predictive signature of psychosis.
Emerging technologies revolutionising disease diagnosis and monitoring in aquatic animal health
Authors: Bohara Kailash , Joshi Pabitra , Acharya Krishna Prasad , Ramena Grace 
Published: October 2023

AbstractIn recent years, aquaculture has seen tremendous growth worldwide due to technological advancements, leading to research and development of various innovations. Aquaculture farmers prioritise early diagnosis for timely treatment to achieve better productive and economic performance. Aquatic animal health experts still employ traditional diagnostic methods using visual diagnosis, cell culture, media culture, histopathology and serology. However, the developments of technologies in aquamedicine, such as sequencing, biosensors and CRISPR, have enabled rapid disease detection within minutes. Furthermore, integrating sensors, drones, artificial intelligence and the internet in aquaculture farm monitoring has helped farmers take decisive actions to improve production. Advancements in diagnostic techniques have significantly enhanced the efficient detection of bacterial, viral, parasitic and fungal diseases in aquatic animals. Moreover, monitoring water quality, aquatic animal health and animal behaviour on farms has become exceptionally streamlined with cutting‐edge tools like drones, sensors and artificial intelligence. Summarising research and development in aquatic animal health and monitoring aids efficient technology adoption in aquaculture. With these advanced technologies' continued development and adoption in developed countries, the aquaculture industry is experiencing growth and increased efficiency, benefiting farmers and consumers in these regions. However, farmers and educators in developing countries lack information about these technologies. Training of agricultural educators and efficient dissemination of knowledge and technologies through advertising and publication in collaboration with companies is essential. This review delves into emerging technologies capable of replacing the conventional diagnostic and monitoring methods utilised in aquaculture. We also explore their strengths, limitations and potential future applications within aquaculture settings.
Educational impact of COVID‐19 on foundation doctors and the decision to take a break from structured approved training programmes in the United Kingdom
Authors: Kilday Colin , Laughey William , Boland Jason W. 
Published: October 2023

AbstractIntroductionThe COVID‐19 pandemic impacted the Foundation Programme for doctors in the United Kingdom. Foundation doctors were working under increased pressure and significant changes were made to their training.AimsThe aim of this study is to explore the educational impact the COVID‐19 pandemic had on foundation doctors and to understand how this resulted in doctors choosing to take time away from structured training programmes within the United Kingdom to make up for lost educational opportunities.MethodsIn this phenomenological research, semi‐structured interviews were carried out with post‐foundation doctors who had completed their training during the pandemic. The data collected from these interviews were coded to carry out a thematic analysis.ResultsAll 12 participants reported that their formalised teaching had been cancelled, and due to the pandemic, many doctors felt that service provision was prioritised over their postgraduate education. Some doctors had positive experiences of informal teaching; however, many felt they missed out on educational opportunities. Doctors acknowledged that this was a contributing factor when deciding to take time out of training. This also resulted in doctors seeking educational opportunities outside of training.DiscussionThe pandemic created many educational challenges for foundation doctors; this has contributed to doctors deciding to take time away from training. In some cases, due to a focus on service provision and their ‘lost education’, doctors are using time away from training to address their own specific educational needs. The impact of this ‘lost education’ requires further research and needs to be considered when doctors do apply to speciality training.
Draft genome sequence of
Janibacter limosus
strain RCAM05316 isolated from Shulgan-Tash cave lime mud
Authors: Sazanova Anna , Belimov Andrey , Gogolev Yuri , Chirak Elizaveta , Afonin Alexey , Karlov Denis , Kuznetsova Irina , Guro Polina , Tikhomirova Nina , Safronova Vera 
Published: October 2023

ABSTRACT

The Shulgan-Tash (Kapova) cave is a unique object for scientific research. In this article, we report the draft genome sequence of
Janibacter limosus
strain P1(28)-3 (RCAM05316) isolated from cave lime mud, Russia (53° 2′ 0″ N, 57° 3′ 0″ E). The sequence was obtained using Oxford Nanopore Technologies MinION.
Screening and combination selection of multifunctional actinomycetes for aerobic composting
Authors: Zhao Zixiao , Liu Huanzhang , Zhao Suxing , Liu Huiqia , Han Yuer , Liu Jianchai 
Published: October 2023

ABSTRACT

To screen the most effective combination of multipurpose actinomycete strains for aerobic composting, lignocellulose-degrading strains were obtained through enrichment culture, separation and purification, and multiselection culture. The isolated strains were identified on the basis of morphology and 16S rRNA gene sequencing and comparison. The obtained actinomycetes were screened for the lignocellulose degradation rate, ammonia and hydrogen sulfide removal rate, and cellulase activity. Subsequently, a combination of strains with ecological coordination and complementary functions was determined through antagonistic tests. The combined strains were subjected to a straw fermentation test to evaluate their degradation effect. As a result, 20 strains of actinomycetes were isolated and identified from more than 56 samples from different sources, including 18 strains of
Streptomyces
sp. and 2 strains of
Nocardiopsis
sp. After a number of screenings, eight strains of actinomycetes with strong function were obtained. From the results of function and antagonistic tests, strains A3, A7, A8, A11, and A16 were selected to form consortia. The straw fermentation test showed that the lignocellulose degradation rate of the strain combination was as high as 39.8%, which was significantly higher than that of eachevery single strain (
P
< 0.05). The screened multifunctional actinomycete strains and their combination enriched the actinomycete germplasm resources used for microbial enhanced aerobic composting.

IMPORTANCE
With the development of animal husbandry in China, the production of a large amount of livestock and poultry manure has become one of the main agricultural pollution sources. High-temperature aerobic composting stands out as one of the most crucial methods for the safe and resourceful utilization of livestock and poultry manure, serving as an essential link between crop cultivation, animal breeding, and sustainable agricultural development. Numerous studies have demonstrated that the addition of exogenous multifunctional bacterial agents to compost reduces not only harmful emissions but also sequesters or increases essential nutrients. However, these efficacies depend on the specific functions of the bacteriophage itself, the harmonization and complementarity within the colony, and its ability to adapt to the environment. In recent years, relatively few studies have been conducted on actinomycetes. This experiment provides excellent actinomycete resources for the production of high-efficiency and high-quality compost compound microbial agents of manure and straw.
BUSINESS MODEL INNOVATION 2.0: A CONCEPTUAL APPROACH TO ADD RESPONSIBILITY
Authors: ERNST VALENTIN , WECHT CHRISTOPH H. , BÖGER MAXIMILIAN , KOPPENHAGEN FRANK 
Published: October 2023

In this paper, a responsible business model innovation process is developed based on the existing process of the St. Gallen Business Model Navigator. For its development, a literature review was conducted to formulate requirements that a responsible business model innovation process should fulfil. In particular, the four guiding principles of responsible research and innovation were considered: anticipation, inclusion, reflection, and responsiveness. Based on these findings, several aspects were added to the Business Model Navigator. The focus was on extending the description of a business model along the magic triangle with two additional levels, the environmental one and the social one. Additionally a new step was added in the initiation phase to make the purpose of the process more visible. The results contribute to the current understanding of a responsible business model innovation process, where ethical, social, and environmental aspects are included as core parts of the business model itself.
Arthroscopic Scaphotrapeziotrapezoid Joint Fusion for Osteoarthritis
Authors: MYLLYKOSKI Jan , RÄISÄNEN Mikko P. , KOTKANSALO Tero , JUNTUNEN Matti , PÄÄKKÖNEN Markus 
Published: October 2023

Background: Arthroscopic scaphotrapeziotrapezoid (STT) fusion (ASTTF) has emerged in the recent decade as an option for traditional open surgery. This retrospective study describes our technique and results of ASTTF. Methods: Medical records and radiological data of patient who had undergone ASTTF between 2014 and 2022 in two tertiary hospitals were reviewed. Results: Five ASTTF in four patients were identified. The mean age of the patients were 52.4 years. Fusion was achieved in four out of five wrists (80%). The mean postoperative radio-scaphoid angle was 48°, grip 32 kg (70% compared to contralateral hand), extension 54° (86%) and flexion 46° (93%). The mean follow-up time was 18 months (range 5 months to 4 years). One wrist (20%) developed STT non-union requiring a reoperation 2 years after index surgery. Conclusions: ASTTF is a technically challenging procedure with a long learning curve and surgery time. However, ASTTF is less invasive compared to the open procedure and our results were like the open procedures described in literature. Further studies are needed to compare the benefits and results of open and ASTTF in a prospective and randomised setup. Level of Evidence: Level IV (Therapeutic)
Aesthetic Considerations in Pollicisation Using the Buck-Gramcko Technique
Authors: DAS DE Soumen , SIVAKUMAR Branavan 
Published: October 2023

The Buck-Gramcko (BG) technique of pollicisation has stood the test of time and provides good to excellent prehensile function in thumb hypoplasia. Proponents of the technique favour it because it provides good exposure to the palmar neurovascular structures. However, the skin flap design may occasionally lead to a ‘finger-like’ appearance with a sharp interdigital cleft and a triphalangeal form. In this report, we describe some of the important aspects of the operative technique so that the outcome is aesthetically pleasing in addition to providing good function. Level of Evidence: Level V (Therapeutic)
Lessons for the Next Generation of Scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium
Authors: Alvarez-Breckenridge Christopher , Anderson Kristin G. , Correia Ana Luisa , Demehri Shadmehr , Dinh Huy Q. , Dixon Karen Olivia , Dunn Gavin P. , Evgin Laura , Goc Jeremy , Good Zinaida , Hacohen Nir , Han Patrick , Hanč Pavel , Hickey John , Kersten Kelly , Liu Beiyun C. , Buque Aitziber , Miao Yuxuan ‘Phoenix’ , Milner J. Justin , Pritykin Yuri , Pucci Ferdinando , Scharping Nicole E. , Sudmeier Lisa , Wang Yufei , Wieland Andreas , Williams Michelle M. 
Published: October 2023

Abstract
The Arthur and Sandra Irving Cancer Immunology Symposium has been created as a platform for established cancer immunologists to mentor trainees and young investigators as they launch their research career in the field. By sharing their different paths to success, the senior faculty mentors provide an invaluable resource to support the development of the next generation of leaders in the cancer immunology community. This Commentary describes some of the key topics that were discussed during the 2022 symposium: scientific and career trajectory, leadership, mentoring, collaborations, and publishing. For each of these topics, established investigators discussed the elements that facilitate success in these areas as well as mistakes that can hinder progress. Herein, we outline the critical points raised in these discussions for establishing a successful independent research career. These points are highly relevant for the broader scientific community.
The Discursive Organization of Disability as a Moral and Epistemic Construct within a University Accommodations Office
Authors: Forbes Shelby 
Published: October 2023

Abstract
Definitions of disability abound, but it has been represented in prevailing social discourses as both proper to the individual and the medical institution. Discourses that portray disability as such are inherently interdiscursive in nature, as they draw upon, and are embedded within, larger discourses of what counts as evidence of not only knowledge, but knowledge of disability in particular. By employing a discourse analytic approach to analyzing in-depth interviews with members of a university accommodations office, I show how they locally reproduce and inadvertently reaffirm such discourses of disability, as they organize disability according to type: physical and cognitive. In their talk, these categories of disability are presented as oppositional and hierarchical constructs, with physical disability being discursively constructed as preferable to cognitive disability. I consider how this practice ties into an empiricist tradition that argues that to know disability means that it must be observable, measurable, or otherwise verifiable.
On the Deadliness of Specialized Dairy Production – The Case of Jersey Herds in Switzerland
Authors: Mann Stefan 
Published: October 2023

Abstract
The jointness of milk and beef production is still the dominant system but is challenged by the trend toward vegetarian diets that skip meat but not milk consumption. Specialized dairy production raises issues regarding the management of male animals that are better known from the case of egg production but which are yet to be explored for dairy herds. In a first step, the problem of male chicklets is presented; similarities and differences to dairy systems are highlighted. A dataset of Swiss cattle is used to show that specialized dairy production as indicated by Jersey cows leads to a shorter life expectancy of both newborn calves and dairy cows compared to the joint production of milk and meat. In a qualitative part, the unsolved problem of economic waste through all male animals and the female animals not needed for milk production is illustrated by using the method of objective hermeneutics. It can be concluded that specialized dairy production does not benefit farm animals.
The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies
Authors: Stocker Kurt , Hartmann Matthias , Ley Laura , Becker Anna M , Holze Friederike , Liechti Matthias E 
Published: October 2023

Background: Research with the Psychedelic Experience Questionnaire/Scale (PES) focuses on questions relating to mystical experience (Mystical Experience Questionnaire (MEQ)). The psychometric potential of the non-MEQ items of the PES remains largely unexplored. Aims: We investigated whether the PES also yields subscales besides the MEQ30 subscales. Methods: Data from 239 PES measurements (140 healthy participants) from six studies with moderate to high doses of lysergic acid diethylamide and/or psilocybin were included. New subscales (with items other than MEQ30) were created and validated as follows: (1) theoretical derivation of candidate items; (2) removal of items with rare experiences; (3) exploratory factor analysis; and (4) confirmatory factor analysis. Correlations of subscales within the PES and between the PES and the 5-Dimensional Altered States of Consciousness Scale (5D-ASC) were performed. In addition, a cluster analysis using all items (except rare experiences) was performed. Results: The reliability of the four original factors of the MEQ30 was confirmed and four additional factors for the non-MEQ items were revealed: paradoxicality, connectedness, visual experience, and distressing experience. The first two additional factors were strongly correlated with the MEQ30 mystical subscale. Adding the new subscales to the MEQ30 subscales increased the explained variance with the 5D-ASC. The cluster analysis confirmed our main results and provided additional insights for future psychedelic psychometrics. Conclusion: The study yields a new validated 6-factor structure for extended mystical experience (MEQ40: MEQ30 + Paradoxicality + Connectedness) and covers psychedelic experience as a whole more comprehensively than has hitherto been possible within a single questionnaire (PES48). The entire PES (PES100) can also be used for further future psychedelic-psychometric research.
Metabolic and Pharmacokinetic Investigation of Ilexsaponin A1 in Normal and Antibiotic-treated Rats
Authors: Cao Di , Wang Zhengjiao , Shen Xiuting , Song Xiaojun , Zhao Zhongxiang 
Published: October 2023

Background Ilexsaponin A1 (IA1) is a bioactive triterpene saponin derived from natural medicinal plants. IA1 exhibits anti-inflammatory and proangiogenic activities and improves intestinal barrier function. It has been reported that IA1 could be metabolized into a dominant metabolite, ilexgenin A (IA) by β-glucosidase enzymes in intestinal microflora. Materials and Methods Herein, an accurate, sensitive, and selective method based on ultra-performance liquid chromatography coupled with mass spectrometry was established to simultaneously profile the metabolism and pharmacokinetic behaviors of IA1 in normal and antibiotic-treated rat plasma after intragastric administration of IA1. The precursor-to-product ion pairs of IA and IA1 were m/ z 501.32↓439.32 and m/ z 663.38↓501.32, respectively. For method validation, the specificity, matrix effect, accuracy, precision, and stability of the pharmacokinetic study were measured, and a calibration curve was created. The collaborative pharmacological target pathways of IA1 and its metabolite IA were investigated using network pharmacology tools. Results The validated analytical method was successfully utilized to investigate the pharmacokinetics of IA1 in normal and antibiotic-treated rats. The bioavailability of IA1 and conversion from IA1 to IA were significantly inhibited by antibiotic-treated rats after oral administration of IA1. Fragment ions at m/z 483.3155, 455.3159, 439.3233, 421.3136, 395.3362, 152.9952, 113.0256, and 71.0531 were characteristic of the IA1 moiety. IA1 was metabolized in rat plasma by biotransformation routes involving deglycosylation, decarboxylation, isomerization, hydrogenation, dehydrogenation, and oxidation. Considering database analysis, IA and IA1 play synergistic role in common pharmacological pathways, such as hypertrophic cardiomyopathy and dilated cardiomyopathy. Conclusion The experiments illustrated that β-glucosidase activity inhibited by antibiotics suppressed the hydrolysis reaction of IA1 in the intestinal tract. IA1 and IA play a synergistic role in exerting effects.
Impact of an Educational Intervention on Hospital Pharmacists’ Knowledge and Application of Substance Withdrawal Management
Authors: Brust-Sisti Lindsay A , Khieu Tiffany , Plotkin Slava , Sturgill Marc G , Moreau Sandy 
Published: October 2023

Background: Patients with substance use disorders are often encountered in an acute care setting and withdrawal management is important. Available literature reveals inadequate acute management of substance withdrawal due to lack of experience and knowledge of medications. Methods: A quality improvement project was implemented to improve hospital pharmacists’ knowledge, application, and practice of inpatient opioid and alcohol withdrawal management through provision of didactic and case-based education and implementation of practice based prospective drug utilization review (PDUR). Pharmacists’ knowledge of the management of alcohol and opioid withdrawal was assessed by a 10-item survey pre-and post-intervention. Results: Twenty-one pharmacists completed the education and pre- and post-surveys. Scores for the 21 pharmacists improved significantly, with pre- and post-intervention scores of 7.33 ± 1.98 and 8.86 ± 0.91, respectively ( P = .0035). Most pharmacists completed their required PDUR submission, and several pharmacist interventions were made and accepted post-education. Pharmacists indicated that the education increased their confidence and enabled them to learn new information that could be directly applied to their pharmacy practice. Conclusion: Providing education and requiring a PDUR improved pharmacists’ knowledge, application, and practice of inpatient opioid and alcohol withdrawal management. Re-education or expanded education may be warranted to further increase pharmacists’ competence.
Reflections on the thoughts of Norman Denzin: His connections to the once and future social work qualitative research
Authors: Gilgun Jane F 
Published: October 2023

Social work qualitative research and the work of Norman Denzin have much in common. Norman’s work was values-based, built on notions of justice, care, dignity, worth, equality, and self-determination with the purpose of identifying and describing problematic social conditions and, in turn, taking action to bring about social change and transformation. This statement fits social work perfectly. In this article, I describe the work of Norman Denzin, show how he promoted qualitative social work research, and how his suggestions for social work researchers to incorporate critical perspectives in our work was calling us back to ourselves. Most of all, he affirmed what we were already doing and want to do better.