bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients
Authors: Durand Claire , Risso Karine , Loschi Michael , Retur Nicolas , Emery Audrey , Courjon Johan , Cluzeau Thomas , Carles Michel 
Published: January 2024

Abstract
Background
The 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile neutropenia in stable patients.

Objectives
To assess the efficacy of an antimicrobial stewardship (AMS) intervention promoting early de-escalation and discontinuation of EAT in high-risk neutropenic patients.

Methods
This before-after study was conducted in the hematology department of the University Hospital of Nice, France. The AMS intervention included the development of clinical decision support algorithms, a twice-weekly face-to-face review of all antibiotic prescriptions and monthly feedback on the intervention. The primary endpoint was overall antibiotic consumption during hospital stay, expressed as days of therapy (DOT).

Results
A total of 113 admissions were included: 56 during the pre-intervention period and 57 during the intervention period. Induction chemotherapy and conditioning for allogeneic stem cell transplantation were the most frequent reasons for admission. In the intervention period, there was a significant decrease in overall antibiotic consumption (median DOT 20 vs. 28 days, p = 0.006), carbapenem consumption (median DOT 5.5 vs. 9 days, p = 0.017) and anti-resistant Gram-positive agents consumption (median DOT 8 vs. 11.5 days, p = 0.017). We found no statistical difference in the rates of intensive care unit admission (9% in each period) and 30-day mortality (5% vs. 0%, p = 0.243). Compliance with de-escalation and discontinuation strategies was significantly higher in the intervention period (77% vs. 8%, p < 0.001).

Conclusion
A multifaceted AMS intervention led to high compliance with early de-escalation and discontinuation of EAT and lower overall antibiotic consumption, without negatively affecting clinical outcomes.
Movement ecology of an endangered mesopredator in a mining landscape
Authors: Cowan M. A. , Dunlop J. A. , Gibson L. A. , Moore H. A. , Setterfield S. A. , Nimmo D. G. 
Published: January 2024

Abstract
Background
Efficient movement and energy expenditure are vital for animal survival. Human disturbance can alter animal movement due to changes in resource availability and threats. Some animals can exploit anthropogenic disturbances for more efficient movement, while others face restricted or inefficient movement due to fragmentation of high-resource habitats, and risks associated with disturbed habitats. Mining, a major anthropogenic disturbance, removes natural habitats, introduces new landscape features, and alters resource distribution in the landscape. This study investigates the effect of mining on the movement of an endangered mesopredator, the northern quoll (Dasyurus hallucatus). Using GPS collars and accelerometers, we investigate their habitat selection and energy expenditure in an active mining landscape, to determine the effects of this disturbance on northern quolls.

Methods
We fit northern quolls with GPS collars and accelerometers during breeding and non-breeding season at an active mine site in the Pilbara region of Western Australia. We investigated broad-scale movement by calculating the movement ranges of quolls using utilisation distributions at the 95% isopleth, and compared habitat types and environmental characteristics within observed movement ranges to the available landscape. We investigated fine-scale movement by quolls with integrated step selection functions, assessing the relative selection strength for each habitat covariate. Finally, we used piecewise structural equation modelling to analyse the influence of each habitat covariate on northern quoll energy expenditure.

Results
At the broad scale, northern quolls predominantly used rugged, rocky habitats, and used mining habitats in proportion to their availability. However, at the fine scale, habitat use varied between breeding and non-breeding seasons. During the breeding season, quolls notably avoided mining habitats, whereas in the non-breeding season, they frequented mining habitats equally to rocky and riparian habitats, albeit at a higher energetic cost.

Conclusion
Mining impacts northern quolls by fragmenting favoured rocky habitats, increasing energy expenditure, and potentially impacting breeding dispersal. While mining habitats might offer limited resource opportunities in the non-breeding season, conservation efforts during active mining, including the creation of movement corridors and progressive habitat restoration would likely be useful. However, prioritising the preservation of natural rocky and riparian habitats in mining landscapes is vital for northern quoll conservation.
Simultaneous resection of a neuroendocrine tumor in an incidental Meckel’s diverticulum with transabdominal preperitoneal hernial repair: a case report
Authors: Kato Shoko , Saito Takuya , Kurahashi Shintaro , Fukami Yasuyuki , Komatsu Shunichiro , Kaneko Kenitiro , Sano Tsuyoshi 
Published: January 2024

Abstract
Background
As laparoscopic surgery becomes more prevalent worldwide, Meckel’s diverticula are increasingly being discovered incidentally during surgery. There is no consensus on whether to follow up or resect such diverticula, which are usually asymptomatic. In cases of transabdominal preperitoneal inguinal hernia repair, resection of such a diverticulum might add the risk of mesh infection. Thus, it is unclear whether simultaneous intestinal resection is advisable.

Case presentation
A 64-year-old man diagnosed with a left indirect inguinal hernia underwent laparoscopic inguinal hernia repair, during which a 2-cm Meckel’s diverticulum located contralateral to the mesentery of the ileum approximately 30 cm from Bauhin’s valve was detected incidentally. Because of the potential risk of future complications such as hemorrhage, diverticulitis, or tumor development, wedge resection of the ileum was performed extracorporeally through an extended umbilical port site after completion of the hernia repair. Pathological examination revealed a neuroendocrine tumor (G1) in Meckel’s diverticulum, which was successfully resected without any mesh infection or postoperative complications.

Discussion
Our patient’s clinical course raises two important issues. First, a Meckel’s diverticulum detected incidentally during laparoscopic surgery should be resected promptly because malignant tumors within such diverticula have frequently been reported. Second, simultaneous resection with hernia repair using mesh seems to be as safe as other clean-contaminated surgery.

Conclusions
Management of incidental Meckel’s diverticula should be selected by appropriate assessment for the risk of malignancy and complications.
Anesthetic Strategies in Cerebral Edema: Navigating Neurological Challenges Amid Trauma, Tumors and Therapeutic Advances
Authors: Świercz Maciej , Markowiak Szymon , Wardęszkiewicz Marta , Jabłońska Wiktoria , Kasprzak Amelia , Truchta Monika , Mańkowska Aleksandra , Kolano Agata , Pejas Anna 
Published: January 2024

Cerebral edema, characterized by abnormal fluid accumulation in brain tissue leading to increased intracranial pressure, poses significant challenges for anesthesiologists. This review delves into the pathophysiology, clinical manifestations, diagnostic approaches, pharmacological strategies, and anesthesiological considerations associated with cerebral edema. Disruptions in the blood-brain barrier, alterations in cerebral blood flow, cellular swelling, and aquaporin dysregulation contribute to the complexity of cerebral edema. Clinical presentations vary, encompassing cognitive changes, seizures, and neurological deficits. Accurate diagnosis relies on clinical assessments and neuroimaging, with MRI and CT scans playing pivotal roles. Pharmacological interventions, including osmotic agents, corticosteroids, diuretics, and barbiturates, target specific causes and symptoms. Anesthesiological challenges encompass ICP monitoring, choice of anesthetic agents, maintenance of cerebral perfusion, fluid management, temperature control, and collaboration with neurosurgical teams. This multidisciplinary approach ensures optimal patient care and emphasizes ongoing research collaboration for refining therapeutic strategies. This comprehensive review provides valuable insights for clinicians managing cerebral edema, offering a roadmap for tailored interventions and highlighting the need for continued advancements in understanding and treating this critical condition.
Material and method: ​​
The literature review applied standard criteria and focused on PubMed articles using keywords: cerebral edema, pathophysiology, aquaporin, blood-brain barrier, anesthesiology, cerebral edema treatment, corticosteroids
Understanding Cooperation in an Intertemporal Context
Authors: Kölle Felix , Lauer Thomas 
Published: January 2024

Cooperation between individuals, a critical component of organizational and societal success, typically involves costs and benefits that accrue at different points in time. Using a series of controlled experiments, this paper provides a comprehensive analysis of the determinants of cooperation in an intertemporal context. Our findings demonstrate that cooperation is significantly reduced when the benefits of cooperation are shifted into the future, whereas delaying costs leads to an increase in cooperation. Our analysis of the underlying behavioral mechanisms reveals that the change in the level of cooperation can be explained by three factors: (i) a shift in the beliefs about others’ efforts, (ii) a shift in the willingness to conditionally cooperate, and (iii) an individual’s degree of impatience. We further find that injunctive norms of cooperation are unaffected by the timing of consequences, indicating that changes in behavior are due to a change in norm compliance rather than the norm itself. Implications for management practices are discussed. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Financial support from the Center for Social and Economic Behavior at the University of Cologne and the Deutsche Forschungsgemeinschaft (German Research Foundation) under Germany’s Excellence Strategy [Grant EXC 2126/1- 390838866] is gratefully acknowledged. F. Kölle gratefully acknowledges funding by the European Research Council under the European Union’s Horizon 2020 research and innovation program [Grant 7414099]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2020.03757 .
Optimal Discoverability on Platforms
Authors: Hagiu Andrei , Wright Julian 
Published: January 2024

Choosing how easy to make it for buyers to discover new sellers is a key design decision for platforms. On one hand, enabling more discoverability generates more transactions and can be more attractive for sellers because they anticipate being discovered by new buyers. On the other hand, discoverability can make sellers more reluctant to participate because they anticipate their existing buyers will discover and purchase from other sellers. We model this fundamental trade-off and study how a platform’s optimal level of discoverability depends on various factors: the degree of substitutability between the sellers’ products; the standalone value of the platform’s tools; the size of the platform’s installed base of buyers; the nature of the platform’s fees, including its ability to charge differential fees depending on whether a transaction is with a seller’s existing buyers or not; the number of sellers; and asymmetries between sellers’ sizes. This paper was accepted by Joshua Gans, business strategy. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.02362 .
Effectiveness of education intervention, with regards to physical activity level and a healthy diet, among Middle Eastern adolescents in Malaysia: A study protocol for a randomized control trial, based on a health belief model
Authors: Al-Haroni Hanan , Nik Farid Nik Daliana , Azanan Mohamad Shafiq 
Published: January 2024

Background
Among the most urgent public health challenges, of the twenty-first century, is obesity. This can be attributed to its relationship with several non-communicable diseases (NCDs), as well as premature mortality. Being overweight or obese is a major concern not only in high-income countries, but also in low-income and middle-income countries, particularly in urban areas. Several studies have highlighted the prevalence of obesity, among Middle Eastern-descent adolescents, studying in Arabic secondary schools, located in Malaysia. Intervention studies, directed at Middle Eastern adolescents in Malaysia, are limited. This paper, describes the protocol, for an integrated health education intervention process. Titled ‘Healthy lifestyle’, it is a primary prevention process, aimed at curbing obesity and disordered eating, among Middle Eastern secondary school adolescents, aged 13–14 years old, residing in Malaysia.

Methods and anticipated results
A cluster randomized controlled study will be conducted, involving 250 Middle Eastern adolescents, in Arabic schools in Malaysia. The participants will be randomly assigned to the intervention and control groups. While the intervention group participates in six weeks of fortnightly six sessions (45 minutes per session), the control group will carry on with their regular curriculums, and normal physical activity routines. The variables which will be evaluated include anthropometric measurements, knowledge, attitude, daily routines, physical activity, sedentary behaviour, food assessment, eating attitudes test-26, and a structured questionnaire based on the HBM. Data will be collected from the intervention and control groups at baseline, post-intervention, and two months following the intervention. Data analysis will be performed by way of the SPSS Statistics software version 26. The generalized estimating equation (GEE) will be used, to test the effect of the intervention program, with regards to the selected variables (outcomes), between and within-group at baseline, as well as six weeks and two months following intervention, after adjusting for clustering. Outcomes will be assessed at each time point, along with a derived average over all three-time points; thus, ensuring that both the cumulative and overall effects are determined.

Conclusions
This trial will provide useful information for improving the knowledge, attitude, and practices of Middle Eastern adolescents, with regards to body weight status, physical activity level, nutrition status (BMI and dietary intake), and disordered eating. This will go a long way, towards ensuring their adherence to appropriate physical activities, and a healthy diet, to keep non-communicable diseases at bay.

Trial registration
This study is registered at NCT: NCT05694143.
Sea level rise from climate change is expected to increase the release of arsenic into Bangladesh’s drinking well water by reduction and by the salt effect
Authors: Frisbie Seth H. , Mitchell Erika J. , Molla Azizur R. 
Published: January 2024

BackgroundOver 165,000,000 people live in Bangladesh; approximately 97% of Bangladeshis drink well water. Approximately 49% of Bangladesh’s area has drinking well water with arsenic (As) concentrations that exceed the 10 micrograms per liter (μg/L) World Health Organization (WHO) guideline. This exposure to a potent carcinogen is a significant threat to public health. About 21% of Bangladesh is flooded each year during a typical monsoon season. As climate change progresses, sea levels will continue to rise, and the area and duration of these annual floods will increase. We hypothesize that these consequences of climate change can increase the release of arsenic from sediments into Bangladesh’s drinking well water.MethodsDrinking well water samples were collected during a national-scale survey in Bangladesh. The dissolved oxygen concentration, oxidation-reduction potential, specific conductance, pH, and temperature were measured at sampling with calibrated portable electronic sensors. The arsenic concentration was measured by the silver diethyldithiocarbamate method.ResultsAs the concentration of dissolved oxygen decreases, the concentration of arsenic increases (p-value = 0.0028). Relatedly, as the oxidation-reduction potential decreases, the concentration of arsenic increases (p-value = 1.3×10−5). This suggests that arsenic is released from sediments into Bangladesh’s drinking well drinking water by reduction. As the specific conductance increases, the concentration of arsenic increases (p-value = 0.023). This suggests that arsenic is also released from sediments into water by the salt effect.ConclusionsRising sea levels can cause a decrease in the dissolved oxygen concentration and oxidation-reduction potential of the underlying aquifer; this should increase the dissolution of insoluble arsenate (H3−xAs(V)O4x−) in sediments by reduction. This, in turn, should release soluble arsenite (H3−xAs(III)O3x−) into the drinking well water. Rising sea levels can cause an increase in the salt concentration of the underlying aquifer; this should increase the release of arsenic from sediments into the drinking well water by the salt effect.
Is dancing an effective intervention for fat loss? A systematic review and meta-analysis of dance interventions on body composition
Authors: Zhang Yaya , Guo Zhicheng , Liu Yin , Zhou Yongxu , Jing Longjun 
Published: January 2024

Objective
The systematic review aimed to review the research on the effects of dance interventions, relative to normal lifestyles, on body composition in people with overweight and obesity.

Methods
7 databases were searched from their inception to 3 July 2023 for studies with dance interventions and normal lifestyles groups. Only studies investigating dance interventions in people with overweight and obesity(body mass index (BMI)>24kg/m2 and percent fat mass (Fat(%)) abnormal(male>20%, female>25%)) were included in the meta-analysis. There were no restrictions on dance forms.

Results
654 studies were identified from the databases, and 10 studies were evaluated to be eligible. The meta-analysis revealed that compared to normal lifestyles dance had meaningful improvements in body mass(BM), BMI, waist circumference(WC), Fat(%), and fat mass(Fat(kg)). No significant differences were found in the waist-to-hip ratio(WHR).

Conclusions
Dance is effective on fat loss in people with overweight and obesity, and has a significant improvement on body composition and morphology. For its high efficiency and greater sense of enjoyment, dance can be a beneficial exercise intervention for fat loss.
Causal associations between liver enzymes and diabetic microvascular complications: A univariable and multivariable Mendelian randomization
Authors: Li Yang , Zhang Qiu 
Published: January 2024

Background
Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The purpose of this research is to examine the independent causal effects of liver enzymes on diabetic microvascular complications.

Methods
Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) were utilized to disentangle the causal effects. The genome-wide association study (GWAS) summary-level statistics were collected from the UK biobank and the FinnGen consortium. Single nucleotide polymorphisms (SNPs) were selected as genetic instruments with genome-wide significance (p < 5 ×10−8). Five UVMR approaches, including inverse variance weighted (IVW), Bayesian weighted Mendelian randomization, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), weighted median, and MR-Egger, and three MVMR approaches, including the extended versions of IVW, MR-Egger, and the Q-minimization methods, were performed to evaluate the causal effects. The robustness of the MR results was further confirmed using several sensitivity analyses.

Results
UVMR revealed that a genetically predisposed per standard deviation increase in serum alanine aminotransferase (ALT) level increased the risk of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) (IVW OR = 1.489, 95% CI = 1.206–1.772, p = 0.006). Likewise, serum aspartate aminotransferase (AST) levels showed similar results (IVW OR = 1.376, 95% CI = 1.115–1.638, p = 0.017). Furthermore, these effects were consistent after controlling for glycemia and blood pressure using MVMR analysis. Additionally, sensitivity analyses further strengthened the causality. However, no significant associations were found between alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and diabetic microvascular complications.

Conclusions
Robust evidence was demonstrated for an independent causal effect of serum ALT or AST concentration on the risk of DR in T2DM. Further investigations are necessary to elucidate the potential biological mechanisms and confirm their clinical significance for early prevention and intervention.
Uso de las redes sociales por las revistas de alto impacto de Comunicación y Ciencias de la información
Authors: Cascón-Katchadourian Jesús , Artigas Wileidys , Arroyo-Machado Wenceslao , Guallar Javier 
Published: January 2024

Se presenta un estudio sobre la adopción de redes sociales por parte de las revistas científicas de mayor impacto (Q1) según el indicador Scimago Journal Rank (SJR) en las categorías de Communication y Library and Information Sciences (LIS). Se ha seguido una metodología descriptiva con un enfoque cuantitativo a través de la revisión de los sitios webs y las redes sociales de las revistas. Se han identificado los perfiles y la actividad de las mismas en las plataformas Twitter, Facebook, Instagram, LinkedIn y YouTube, se ha analizado su actividad según tipos de editoriales en relación a su tamaño y se han comparado los resultados entre las dos áreas, mostrando sus similitudes y diferencias. Entre las principales aportaciones se evidencia un comportamiento diferente entre las dos categorías estudiadas, con una mayor adopción de los medios sociales en el área de Communication, un claro predominio de la plataforma Twitter en todos los casos y una mayor presencia en redes de las revistas de editoriales pequeñas e independientes que de las editoriales grandes y gigantes. Entre las limitaciones de esta investigación se puede señalar la ausencia de un análisis de contenido de las publicaciones, que se propone para futuros estudios.