bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protest Resonances across the Global South: Democratic Deficit, Inequality and Indignity
Authors: Brooks Heidi 
Published: November 2023

Abstract
During the first two decades of the 21st century, protest has emerged as part of a normalised repertoire of political participation employed by citizens world-over. In the Global South, protests have seen both scale and impact, centring on a range of short- and long-term grievances, and making calls for political and economic change. This article conducts a cross-regional comparative analysis of contentious action in the Global South, drawing out some of the thematic and substantive parallels that might help us better understand the drivers of protest since the 2000s. Drawing on a range of protest data, media sources and secondary analysis, it focuses in particular on protest in Africa, Latin America and Asia. Making use of the wealth of existing protest literature, the article moves beyond a national or regional analysis to highlight the ways in which protest drivers and underpinnings in various locations of the South may resonate with the region’s broader wave of post-2000 protest. The article posits that the drivers of protest can be linked to three overarching themes: democratic deficit and (ine)quality of representation; neoliberalism and expanding inequality; and concerns of citizenship, dignity and inclusion. Underpinning these identifiable themes is the prevalence of experiences of popular exclusion. The article also foregrounds calls for ‘dignity’ as central to understanding the demands and drivers of protest. It is hoped that this initial survey will contribute to further attempts to understand contentious action through an increasingly global lens.
Teaching Social Justice Activism through Radical Community-Based Learning
Authors: Russell Vincent 
Published: November 2023

Abstract
Given the numerous crises facing the world, this essay argues that educators need to turn to the radical tradition to teach students social justice activism. Reflecting on my experience teaching social justice activism, the essay describes a pedagogical approach called radical community-based learning (cbl), wherein faculty and students partner with grassroots social movements, groups, and/or organizations to engage in political activism for social justice. Radical cbl promotes place-based consciousness and place-based activism so that students gain experience making material differences in their local communities. Through radical cbl, students learn theories and skills for community organizing, and faculty see themselves as inextricably linked with the communities in which they work and live. The essay offers an overview of radical cbl and provides resources for teaching social justice activism through radical cbl.
Is There a Cosmic Covenant?
Authors: Otto Randall E. 
Published: November 2023

Abstract
The idea of a cosmic covenant originated within Roman Catholicism in the mid-twentieth century. Jean Daniélou used it first as the order God gave in nature by which he is known to those outside of Israel. Though this supports interreligious dialogue, it confuses covenant with providence and may diminish the centrality of Christ to salvation. Mary Daly later took up the phrase and attached to it ideas of a sisterhood of universal harmony in which all distinctions are dissolved in being, intuited similarly to dialogical personalism. Robert Murray then grounded the idea in traces of a divinely willed order in nature and society unearthed from vestiges of ritual expression thought to remain in the Old Testament. In each of these usages, the idea of cosmic covenant falls short of what covenant entails, a relationship established between rational entities, ultimately by God with human beings, to establish loving obedience among those made in his image.
Soft Tissue Aneurysmal Bone Cyst in the Sartorius Muscle of a 13-Year-Old Boy Mimicking Myositis Ossificans: Case Report
Authors: Pena-Burgos Eva Manuela , Serra del Carpio Gabriela , Bernabéu Daniel , Cordero García Jose Manuel , Ortiz-Cruz Eduardo Jose , Pozo-Kreilinger Jose Juan 
Published: November 2023

Introduction A soft tissue aneurysmal bone cyst is an extremely rare tumor. The objective of the article is to present the clinical, radiological, and histopathological features of a very unusual neoplasm of soft tissues. Case report A 13-year-old male patient presented a painful, mobile, and rapidly growing mass on the posteromedial aspect of his left knee. Imaging studies revealed a mass that arose from the medial surface of the distal sartorius muscle, with extension to the subcutaneous fat tissue. It was a well-circumscribed solid tumor with a peripheral rim calcification on plain film, computerized tomography, and ultrasound (zonal phenomenon). On magnetic resonance imaging, a heterogenous mass on T1-weighted images (WI) and T2-WI was seen, with a peripheral hypointense rim in both sequences. An outstanding edema on T2-WI extending to the soft tissue and muscles of the medial compartment of the knee was detected. The mass was resected, and the “tumoral mimickers” histopathological and molecular (next-generation sequencing) diagnoses confirmed a soft tissue aneurysmal bone cyst. A follow-up showed that the patient was free of disease 12 months after surgery. Conclusion Soft tissue aneurysmal bone cyst is a rare tumor. Appropriate clinical and radiological correlation should be performed to differentiate it from other tumor mimickers.
Surgical management of feline biliary tract disease: decision-making and techniques
Authors: Low Daniel , Williams John 
Published: November 2023

Practical relevance: Diseases of the hepatobiliary system are not uncommon in first-opinion practice. The anatomy of the feline hepatobiliary tract differs from that of dogs and may predispose cats to inflammatory hepatobiliary disease. Case management can be challenging, and the prognosis is variable and dependent on the underlying disease process. Clinical challenges: Biliary tract disease in the cat has non-specific clinical signs that overlap with those of diseases of other body systems. Diagnostic tests of the hepatobiliary system are widely available, but interpretation of results can be challenging. Deciding on medical or surgical management can also be challenging; for example, various degrees of cholestasis may be seen with different diseases and disease severities, and will influence the decision to manage the patient medically or surgically. Surgery is indicated in cases of bile peritonitis, severe cholestasis, focal neoplasia or disease that is refractory to medical management. Intensive perioperative and postoperative management, with 24 h hospitalisation facilities, is essential. Audience: This review article is written for the small animal general/primary care practitioner, with an emphasis on decision-making in the surgical management of feline hepatobiliary disease. Evidence base: Evidence available in the published literature is reviewed and presented, and the inherent limitations are discussed.
Numerical and experimental study of a segmentally prefabricated orthotropic steel–ultra-high-performance concrete composite deck for long-span cable-stayed bridges
Authors: Tan Xingyu , Fang Zhi , Zhu Qimu , Liao Yuan , Tang Shoufeng , Zhang Fa 
Published: November 2023

Utilizing the high strengths, toughness, and durability of ultra-high-performance concrete (UHPC), a segmentally prefabricated orthotropic steel–UHPC composite deck (POSUCD) system has been developed for long-span cable-stayed bridges. The deck system combines an orthotropic steel deck (OSD) with a reinforced UHPC layer using notched perfobond strips (NPBLs). The UHPC layer is prefabricated onto the OSD of the girder segment in the factory to form the POSUCD. After the precast UHPC layer is cured, the girder segments are transported to the bridge site and assembled. The precast UHPC layers are then connected via transverse wet joints before tensioning stay cables. Against the background of the Danjiangkou Reservoir Bridge with a main span of 760 m, finite element (FE) analysis was conducted to examine the stress state and flexural tests were carried out on local full-scale models to verify the feasibility of POSUCD. The results show that the prefabricated UHPC layer reduces the maximum static compressive stress of the steel deck in the girder system by 21%, and the stress ranges at fatigue-prone details of the steel deck are decreased by 28%–90% compared to traditional OSDs with asphalt overlay. Since the prefabricated UHPC layer helps withstand dead axial load in the main girder, the high compressive strengths of UHPC can be utilized more effectively than in deck systems with UHPC only used as a cast-in-situ overlay to resist vehicular wheel loads. The transverse wet joint interfaces were identified as the weakest aspect of the POSUCD, whether under tension or compression; however, their nominal flexural strengths along the longitudinal direction meet the required design standards. The shear resistance of NPBLs was also well confirmed by the minimal interfacial slip on the specimen when it reached the ultimate capacity under positive bending moment.
Characteristics, primary treatment, and survival of MDS/MPN with neutrophilia: a population-based study
Authors: Klein Saskia K. , Huls Gerwin A. , Visser Otto , Kluin-Nelemans Hanneke C. , Dinmohamed Avinash G. 
Published: November 2023

Abstract
Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, until recently called atypical chronic myeloid leukemia (aCML), being part of the MDS/MPN is a very rare disease with poor prognosis. Although emerging data reveal its cytogenetic and molecular profile, integrated survival and treatment data remain scarce. We analyzed a cohort of 347 adult patients diagnosed with MDS/MPN with neutrophilia, registered in the Netherlands Cancer Registry between 2001 and 2019. Our demographic baseline data align with other cohorts. We observed cytogenetic aberrations exclusively in patients aged &gt;65 years, with trisomy 8 being the most common abnormality. We identified 16 distinct molecular mutations, with some patients (16/101) harboring up to 3 different mutations; ASXL1 being the most frequent one (22%). In a multivariable Cox regression analysis, only age, hemoglobin level and allogeneic hematopoietic stem cell transplant (alloHSCT) were associated with overall survival (aged &gt;65 years; hazard ratio [HR] 1.85; P = .001 and alloHSCT HR, 0.51; P = .039). Because no other treatment modality seemed to affect survival and might cause toxicity, we propose that all patients eligible for alloHSCT should, whenever possible, receive an allogeneic transplant. It is imperative that we strive to improve outcomes for patients who are not eligible for alloHSCT. Tackling this challenge requires international collaborative efforts to conduct prospective intervention studies.
PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
Authors: Li Wei , Xue Lu , Peng Changsi , Zhao Ping , Peng Yongbo , Chen Weiwei , Wang Wenyi , Shen Jinhua 
Published: November 2023

Abstract
Background
Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Herein, we investigated the therapeutic activities of PP121 in asthma treatment.

Methods
Tension measurements and patch clamp recordings were made to investigate the anticontractile characteristics of PP121 in vitro. Then, an asthma mouse model was established to further explore the therapeutic characteristics of PP121 via measurement of respiratory system resistance, histological analysis and western blotting.

Results
We discovered that PP121 could relax precontracted mouse tracheal rings (mTRs) by blocking certain ion channels, including L-type voltage-dependent Ca2+ channels (L-VDCCs), nonselective cation channels (NSCCs), transient receptor potential channels (TRPCs), Na+/Ca2+ exchangers (NCXs) and K+ channels, and accelerating calcium mobilization. Furthermore, PP121 relieved asthmatic pathological features, including airway hyperresponsiveness, systematic inflammation and mucus secretion, via downregulation of inflammatory factors, mucins and the mitogen-activated protein kinase (MAPK)/Akt signaling pathway in asthmatic mice.

Conclusion
In summary, PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment, which suggests that PP121 might be a promising therapeutic compound and shed new light on asthma therapy.
Ab initio protein structure prediction: the necessary presence of external force field as it is delivered by Hsp40 chaperone
Authors: Roterman Irena , Stapor Katarzyna , Konieczny Leszek 
Published: November 2023

Abstract
Background
The aqueous environment directs the protein folding process towards the generation of micelle-type structures, which results in the exposure of hydrophilic residues on the surface (polarity) and the concentration of hydrophobic residues in the center (hydrophobic core). Obtaining a structure without a hydrophobic core requires a different type of external force field than those generated by a water. The examples are membrane proteins, where the distribution of hydrophobicity is opposite to that of water-soluble proteins. Apart from these two extreme examples, the process of protein folding can be directed by chaperones, resulting in a structure devoid of a hydrophobic core.

Results
The current work presents such example: DnaJ Hsp40 in complex with alkaline phosphatase PhoA-U (PDB ID—6PSI)—the client molecule. The availability of WT form of the folding protein—alkaline phosphatase (PDB ID—1EW8) enables a comparative analysis of the structures: at the stage of interaction with the chaperone and the final, folded structure of this biologically active protein. The fuzzy oil drop model in its modified FOD-M version was used in this analysis, taking into account the influence of an external force field, in this case coming from a chaperone.

Conclusions
The FOD-M model identifies the external force field introduced by chaperon influencing the folding proces. The identified specific external force field can be applied in Ab Initio protein structure prediction as the environmental conditioning the folding proces.
Single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery: a prospective randomized comparative trial
Authors: Zhou Anneng , Wang Ying , Cheng Yonghong , He Mei , Duan Yongting , Qin Dongfang , Jiang Mengbi 
Published: November 2023

Abstract
Background
To investigate the effects of a single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery.

Methods
Forty patients, 25 males and 15 females, aged 18–85 years with ASA class I or II underwent unilateral clavicular fracture internal fixation. The patients were randomly divided into a superficial cervical plexus block group (group S, n = 20) and a superficial cervical fascia block group (group F, n = 20). First, the brachial plexus of the intermuscular sulcus of all patients was blocked with an ultrasound-guided injection of one injection with 15ml 0.33% ropivacaine 15ml in both groups. Second, the superficial cervical plexus was blocked by another injection of 5-8ml 0.33% ropivacaine in group S, and the superficial cervical fascia was blocked by an injection with 5-8ml 0.33% ropivacaine in Group F. We evaluated operation time, onset time of anaesthesia, effective time and the grades of nerve block effect in the two groups. Additionally, we evaluated the incidences of local anaesthetic poisoning, hoarseness, dyspnoea, and postoperative nausea and vomiting, and the number of patients requiring remedial analgesia within 24 h. Repeated measurements were analysed by repeated data analysis of variance, and count data were compared by the χ2 test. A P value < 0.05 was considered statistically significant.

Results
The operation time and onset time in Group F were significantly shorter than those in group S (P < 0.05); the effect of intraoperative block was better than that in group S (P < 0.05), and the effective time was significantly longer in group F than in group S (P < 0.05). However, no severe case of dyspnoea, local anaesthetic poisoning or hoarseness after anaesthesia occurred in either of two groups. There was no significant difference in the rate of postoperative salvage analgesia or that of postoperative nausea and vomiting between the two groups.

Conclusions
The application of the single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery is beneficial because it shortens the operation time, has a faster onset, produces a more effective block and prolongs the longer analgesia time.

Trial registration
Chinese Clinical Trial Registry- ChiCTR2200064642(13/10/2022).
Effect of dexamethasone and ramosetron on the prevention of postoperative nausea and vomiting in low-risk patients: a randomized, double-blind, placebo-controlled, multicenter trial
Authors: Kim Jong-Ho , Kim Jin-Sun , Jeon Yeong-Gwan , Bae Jangho , Shin Kiyoung , Hwang Byeongmun 
Published: November 2023

Abstract
Background
Several studies have investigated the effect of antiemetics on postoperative nausea and vomiting (PONV) in high-risk groups. However, few studies have investigated the effect of antiemetics in patients at low risk of developing PONV.

Methods
In this prospective, randomized, double-blinded trial, 177 patients undergoing surgery under general anesthesia were randomly allocated to three groups. Patients allocated to group C (control group) received 2 mL of intravenous 0.9% saline, those allocated to group R (ramosetron group) received 0.3 mg of intravenous ramosetron, and those allocated to group DR (ramosetron plus dexamethasone group) received 5 mg of intravenous dexamethasone and 0.3 mg of intravenous ramosetron.

Results
Finally, 174 patients completed the study, and the types of surgeries were orthopedic (n = 80), rhinologic (n = 47), urologic (n = 29), and others (n = 18). The incidence of PONV up to 48 h postoperatively was significantly lower in group DR than in group C. The incidence of PONV up to 0–1 h postoperatively was significantly lower in groups R and DR than in group C. The usage pattern of rescue antiemetics was consistent with the incidence of PONV. The percentage of patients requiring rescue analgesics 0–1 h postoperatively was significantly lower in groups R and DR than in group C.

Conclusions
The combination of dexamethasone and ramosetron demonstrated a superior effect in preventing PONV for 48 h after surgery under general anesthesia than saline in patients at low risk of developing PONV. Compared with saline injections, ramosetron injections yielded better outcomes for the incidence of PONV and the use of rescue antiemetics and rescue analgesics 0–1 h postoperatively.

Trial registration
Clinical trial registration number: criskorea@korea.kr, KCT0006749.
Association between type D personality and supportive care needs in elderly patients with breast cancer: a prospective longitudinal observational study
Authors: Wang Suxing , Li Yuan , Li Shu , Zhang Enming , Dai Zhengyue , Cui Jiasong , Wang Xiaolong , Fang Qiong 
Published: November 2023

Abstract
Background
Elderly patients with breast cancer often have more unmet needs after receiving common treatments such as surgery and chemotherapy. Type D personality has been related to supportive care needs in the general population. However, its association with supportive care needs in elderly breast cancer patients has not been prospectively explored. This study aimed to address this gap.

Objectives
The aim was to understand the impact of Type D personality on the supportive care needs of elderly breast cancer patients at diagnosis, 2 weeks postoperatively, 3 months postoperatively, and 6 months postoperatively and to analyse the impact of Type D personality on the changing trajectory of supportive care needs after controlling for confounding factors such as demographics, symptom distress and social support.

Methods
A total of 122 elderly patients (≥ 65 years) with breast cancer in Ruijin Hospital, Shanghai, China, were included from September 2021 until August 2022. Supportive care needs were measured by the Supportive Care Needs Survey Short Form and tracked at diagnosis, 2 weeks postoperatively, 3 months postoperatively, and 6 months postoperatively. To investigate changes in the supportive care needs of elderly breast cancer patients and the effect of Type D personality on these needs, a linear mixed model was applied.

Results
A total of 122 elderly patients participated. There was an overall decreasing trend in supportive care needs, with Type D personality patients having significantly higher levels of supportive care needs than the non-Type D personality patients at all stages. Through linear mixed models, it was found that the Type D personality group had a lower overall downward trend than the non-Type D personality group, with need levels remaining consistently higher. This difference persisted after controlling for demographic information, symptom burden, social support.

Conclusions
Elderly breast cancer patients with Type D personality had higher levels of supportive care needs and a slower rate of decline that was maintained over a longer period than those with non-Type D personality.