bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient implementation on accuracy improvement of the two-dimensional node-to-segment contact approach for explicit dynamic analysis
Authors: Kang Seung-Hoon , Lee Seok-Min , Shin SangJoon 
Published: December 2023

AbstractThe penalty-method-based node-to-segment (NTS) approach is widely employed in the explicit dynamic analysis owing to its computational efficiency and implementation simplicity. However, the classical approach does not pass the contact patch test and results in severe inaccuracies. This study attempts the accuracy enhancement of an explicit dynamic contact analysis with minimum efficiency loss using the NTS algorithm with the modified area regularization technique (NTS-mAR). The computational procedure is compared to an allied modified penalty-method-based NTS approach, i.e., the virtual node-to-segment algorithm passing the patch test (VTS-PPT). Then, an extension to an explicit dynamic analysis framework is attempted, wherein the speed of the contact force calculation significantly influences the overall computational efficiency. The cost of the remaining computation was minimized by employing a lumped mass matrix and a one-point integration rule for the internal force. Elastoplasticity was considered to extend its application. The accuracy improvement compared to the classical one-pass NTS approach was similar for the modified approaches. The VTS-PPT approach requires more than twice the cost of contact force estimation compared with the classical one-pass NTS approach. In contrast, NTS-mAR approach induces a cost increase from 6 to 36% that of classical one-pass NTS approaches. For the given examples, the NTS-mAR approach is beneficial when an improvement in accuracy is desired with minimum efficiency loss.
Ongoing impacts of childhood-onset glomerular diseases during young adulthood
Authors: Furuie Keishiro , Kuraoka Shohei , Ban Hideki , Hidaka Yuko , Nagata Hiroko , Tamura Hiroshi , Nagano Koji , Kawano Tomoyasu , Furuse Akio , Nakazato Hitoshi , Nakamura Kimitoshi 
Published: December 2023

Abstract
Background
Childhood-onset glomerular disease often requires ongoing treatment and follow-up into adulthood. However, few studies have analyzed the associated impact and distress experienced by patients with this condition during the transition from childhood to adolescence and adulthood.

Methods
At three facilities, we recruited patients who developed idiopathic nephrotic syndrome or IgA nephropathy during childhood and were at least 18 years old at the time of study entry. Among them, a questionnaire-based survey was administered to patients who consented to participate, and the results were analyzed in conjunction with clinical information.

Results
Data from a total of 38 patients were analyzed. Of these patients, 15 had idiopathic nephrotic syndrome and 23 had IgA nephropathy. The age of transition from pediatrics to the adult medicine department was correlated with the number of recurrences. Many patients also reported being significantly affected by exercise restrictions and physical decline associated with their diseases and medications. Various impacts, including distress, affected decision-making regarding higher education, with patients engaging in higher education at a significantly higher rate compared with the regional average (66.7% vs. 46.9%, p = 0.028).

Conclusion
We analyzed the impact of childhood-onset glomerular disease and distress during the transition period from pediatric to adult care. This study highlighted the significant impact of medications and exercise restrictions on patients’ decisions regarding higher education. Future prospective studies will be needed to examine patients’ distress in more detail and establish management approaches to enhance patient quality of life.

Graphical abstract
How early should be “Early Integrated Palliative Care”?
Authors: Chelazzi Cosimo , Ripamonti Carla Ida 
Published: December 2023

AbstractPalliative care, with its focus on comprehensive patient assessment encompassing physical, social, emotional, and spiritual pain, plays a crucial role in modern medicine. Despite its significance, integration with oncology and other healthcare specialties often occurs late in the disease trajectory. Strategies to bridge this gap include considering a “rebranding” of palliative care to “supportive care.” Early initiation of palliative care, although challenging to define precisely, aims to improve the quality of life for patients and their families. Studies show some benefits, but the evidence remains limited. An embedded model that encourages interdisciplinary collaboration between oncologists and palliative care practitioners has shown promise. However, it raises questions about training and availability of palliative care specialists. A broader approach involves integrating palliative care principles into medical and nursing education to ensure early recognition of patient needs and empathetic communication. Regular monitoring of patients’ physical and non-physical needs, along with appropriate interventions, can alleviate suffering and improve patient outcomes. Ultimately, the integration of palliative care into oncology and other disciplines focuses on addressing the individual’s needs and understanding their unique experience of suffering.
Comparison of the patient-derived modified Japanese Orthopaedic Association scale and the European myelopathy score
Authors: de Dios Eddie , Löfgren Håkan , Laesser Mats , Lindhagen Lars , Björkman-Burtscher Isabella M. , MacDowall Anna 
Published: December 2023

Abstract
Purpose
To compare the patient-derived modified Japanese Orthopaedic Association (P-mJOA) scale with the European myelopathy score (EMS) for the assessment of patients with degenerative cervical myelopathy (DCM).

Methods
In this register-based cohort study with prospectively collected data, included patients were surgically treated for DCM and had reported both P-mJOA and EMS scores at baseline, 1-year follow-up, and/or 2-year follow-up to the Swedish Spine Register. P-mJOA and EMS scores were defined as severe (P-mJOA 0–11 and EMS 5–8), moderate (P-mJOA 12–14 and EMS 9–12), or mild (P-mJOA 15–18 and EMS 13–18). P-mJOA and EMS mean scores were compared, and agreement was evaluated with Spearman’s rank correlation coefficient (ρ), the intraclass correlation coefficient (ICC), and kappa (κ) statistics.

Results
Included patients (n = 714, mean age 63.2 years, 42.2% female) completed 937 pairs of the P-mJOA and the EMS. The mean P-mJOA and EMS scores were 13.9 ± 3.0 and 14.5 ± 2.7, respectively (mean difference –0.61 [95% CI –0.72 to –0.51; p < 0.001]). Spearman’s ρ was 0.84 (p < 0.001), and intra-rater agreement measured with ICC was 0.83 (p < 0.001). Agreement of severity level measured with unweighted and weighted κ was fair (κ = 0.22 [p < 0.001]; κ = 0.34 [p < 0.001], respectively). Severity levels were significantly higher using the P-mJOA (p < 0.001).

Conclusion
The P-mJOA and the EMS had similar mean scores, and intra-rater agreement was high, whereas severity levels only demonstrated fair agreement. The EMS has a lower sensitivity for detecting severe myelopathy but shows an increasing agreement with the P-mJOA for milder disease severity. A larger interval to define severe myelopathy with the EMS is recommended.
Künstliche Intelligenz in der Neuroonkologie
Authors: Nowosielski-Krappinger Martha 
Published: December 2023

ZusammenfassungKünstliche Intelligenz ist in aller Munde, teilweise bemerkt, großteils jedoch unbemerkt, ist sie seit vielen Jahren Teil unseres Lebens. Die Bestrebungen, menschliche Intelligenz zu mechanisieren, bestehen schon seit den 1950er-Jahren. Erst die technischen und mathematischen Errungenschaften der letzten 20 Jahre haben die Anwendung erleichtert, sodass unterschiedliche Institutionen die künstliche Intelligenz in ihrem (Arbeits‑)Alltag nützen. Auch die Medizin bedient sich der künstlichen Intelligenz, im Folgenden exemplarisch dargestellt für neuroonkologische Erkrankungen. Als multidisziplinäres Fach müssen viele Faktoren (Bildgebung, molekulare und genetische wie auch klinische Faktoren) miteinander in Zusammenhang gebracht werden, um den Patient:innen die bestmögliche Behandlung anzubieten. Je größer der Datensatz, desto eher ist man auf eine computerbasierte Unterstützung in Form von künstlicher Intelligenz angewiesen. Wie künstliche Intelligenz funktioniert und in welchen Bereichen sie in der Neuroonkologie Anwendung findet, wird im folgenden Artikel beleuchtet.
A new window Clause for SQL++
Authors: Fang James , Lychagin Dmitry , Carey Michael J. , Tsotras Vassilis J. 
Published: December 2023

AbstractWindow queries are important analytical tools for ordered data and have been researched both in streaming and stored data environments. By incorporating ideas for window queries from existing streaming and stored data systems, we propose a new window syntax that makes a wide range of window queries easier to write and optimize. We have implemented this new window syntax in SQL++, an SQL extension that supports querying semistructured data, on top of AsterixDB, a Big Data Management System, thus allowing us to process window queries over large datasets in a parallel and efficient manner.
Identifying and Qualifying Deviant Cases in Clusters of Sequences: The Why and The How
Authors: Piccarreta Raffaella , Struffolino Emanuela 
Published: December 2023

Abstract
Sequence analysis is employed in different fields—e.g., demography, sociology, and political sciences—to describe longitudinal processes represented as sequences of categorical states. In many applications, sequences are clustered to identify relevant types, which reflect the different empirical realisations of the temporal process under study. We explore criteria to inspect internal cluster composition and to detect deviant sequences, that is, cases characterised by rare patterns or outliers that might compromise cluster homogeneity. We also introduce tools to visualise and distinguish the features of regular and deviant cases. Our proposals offer a more accurate and granular description of the data structure, by identifying—besides the most typical types—peculiar sequences that might be interesting from a substantive and theoretical point of view. This analysis could be very useful in applications where—under the assumption of within homogeneity—clusters are used as outcome or explanatory variables in regressions. We demonstrate the added value of our proposal in a motivating application from life-course socio-demography, focusing on Italian women’s employment trajectories and on their link with their mothers’ participation in the labour market across geographical areas.
Definiteness marking in American Norwegian: a unique pattern among the Scandinavian languages
Authors: van Baal Yvonne 
Published: December 2023

AbstractThis paper examines definiteness marking in American Norwegian (AmNo), a heritage variety of Norwegian spoken in the US. The description adds another language to the much-studied variation within Scandinavian nominal phrases. It builds on established syntactic analysis of Scandinavian and investigates aspects that are (un)like Norwegian spoken in the homeland. A central finding is that the core syntax of Norwegian noun phrases is retained in AmNo, while the morphophonological spell-out is sometimes different. Indefinite determiners, for example, are obligatory in AmNo, but some speakers produce them with non-homeland-like gender agreement. One systematic change is observed: double definiteness has been partially lost. The typical AmNo modified definite phrase lacks the prenominal determiner that is obligatory for varieties in Norway. I argue that this is a syntactic change which allows the realization of D to be optional. This is a pattern not found in the other Scandinavian languages. At the same time, this innovative structure in AmNo is not like English, the dominant language of the AmNo speakers. This demonstrates heritage language change that is distinct from both the homeland language and the dominant language.
Ruxolitinib Rescues Multiorgan Clinical Autoimmunity in Patients with APS-1
Authors: Lévy Romain , Escudier Agathe , Bastard Paul , Briand Coralie , Polivka Laura , Stoupa Athanasia , Talbotec Cécile , Rothenbuhler Anya , Charbit Marina , Debray Dominique , Bodemer Christine , Casanova Jean-Laurent , Linglart Agnès , Neven Bénédicte 
Published: December 2023

AbstractAutoimmune polyendocrine syndrome type-1 (APS-1) is caused by mono- or biallelic loss-of-function variants of the autoimmune regulator gene AIRE underlying early-onset multiorgan autoimmunity and the production of neutralizing autoantibodies against cytokines, accounting for mucosal candidiasis and viral diseases. Medical intervention is essential to prevent or attenuate autoimmune manifestations. Ruxolitinib is a JAK inhibitor approved for use in several autoimmune conditions. It is also used off-label to treat autoimmune manifestations of a growing range of inborn errors of immunity. We treated three APS-1 patients with ruxolitinib and followed them for at least 30 months. Tolerance was excellent, with no medical or biological adverse events. All three patients had remarkably positive responses to ruxolitinib for alopecia, nail dystrophy, keratitis, mucosal candidiasis, steroid-dependent autoimmune hepatitis, exocrine pancreatic insufficiency, renal potassium wasting, hypoparathyroidism, and diabetes insipidus. JAK inhibitors were therefore considered an effective treatment in three patients with APS-1. Our observations suggest that JAK/STAT pathways are involved in the pathogenesis of APS-1 autoimmune manifestations. They also suggest that JAK inhibitors should be tested in a broader range of APS-1 patients.
The Purpose of Double Accenting in the Ormulum and a Possible French Connection
Authors: Jakobs Jannis 
Published: December 2023

AbstractBased on a study contrasting the spellings of the Ormulum’s (Oxford, Bodleian Library, MS Junius 1) Hand C with those of Orm, this article proposes that final < tt > did not necessarily indicate a short preceding vowel in the hypothesized spelling system which Orm sought to reform, and that the Ormulum’s double accent marks might serve to prophylactically counteract a spelling habit present in Orm’s house of doubling final < t > following an etymological long vowel. It argues thus against previous explanations which tend to construe the double accents as redundant markers of vowel length. Further evidence is adduced to suppose that the unexpected doubling of final < t > could have been a post-Conquest orthographical tendency arising from the intermixture of English and (Anglo-)French spelling systems.
Do physical fitness and cognitive function mediate the relationship between basic activities of daily living and quality of life in older adults with dementia?
Authors: Barros Duarte , Borges-Machado Flávia , Silva-Fernandes Anabela , Ribeiro Oscar , Carvalho Joana 
Published: December 2023

Abstract
Purpose
Independence in activities of daily living (ADLs) is associated with quality of life (QoL) in individuals with dementia. However, the contribution of physical and cognitive functions to this relationship needs further examination. This study aims to examine the mediating effect of physical fitness and cognitive function in the relationship between independence in basic ADLs and QoL among older adults with dementia.

Methods
This cross-sectional study included 107 older adults with dementia (74.8% women; age 78.21 ± 7.70 years). Independence in basic ADL and QoL were evaluated using the Barthel Index (BI) and QoL- Alzheimer’s Disease Scale, respectively. The Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Mini-Mental State Examination were applied to assess cognitive function. Physical fitness was evaluated using the 30-s chair stand, 2-min step and the Timed-Up and Go tests. A structural equation modelling (SEM) with bootstrapping estimation was conducted to determine the relationship between all variables.

Results
Independence in basic ADL positively affected QoL and this association was mediated by physical fitness (β = 0.242, p = 0.011). No statistically significant results were observed when testing cognitive function as a mediator between BI and QoL (β = 0.009, p = 0.345).

Conclusions
Physical fitness (i.e., lower body strength, aerobic capacity, and mobility) plays a role in the relationship between basic ADL independence and QoL of older adults with dementia, reinforcing the need to improve and monitor these parameters throughout the disease progression. Future longitudinal studies should explore the temporal relationship between physical and cognitive function and its contribution to basic ADL independence and QoL.
Quantitative measurement of link failure reaction time for devices with P4-programmable data planes
Authors: Franco David , Higuero Marivi , Zaballa Eder Ollora , Unzilla Juanjo , Jacob Eduardo 
Published: December 2023

AbstractQuick handling of link failures remains a challenging issue in current communication networks, although it is crucial to many routing algorithms. Link failures are the leading cause of packet losses and delays, therefore, failure recovery is tied to stringent requirements for certain services, such as the sub-50 millisecond completion time for carrier-grade networks, which is sometimes difficult to achieve in traditional routing schemes. For this reason, fast recovery strategies are key pillars of modern communication networks. In this paper, we demonstrate the benefits of the devices with Programmable Data Planes (PDP) for fast reacting to link failures. We first review the link failure detection, reaction and recovery procedures and then we discuss the main fast failure recovery mechanisms employed by different types of devices in current communication networks. In addition, we present a novel method to measure the link failure reaction time of an Intel Tofino switch with PDP, as well as the results obtained when measuring such time using real hardware equipment. Our results show that such hardware devices provide a failure reaction time in the order of microseconds, with an average of 472.88$$\upmu $$
μ
s, which poses PDP as a key technology to achieve zero packet loss and zero delay failure recovery.
Objectively measured adherence may affect side effects of mandibular advancement therapy in subjects with obstructive sleep apnea
Authors: Pahkala Riitta 
Published: December 2023

Abstract
Purpose
The purpose of this study was to determine if objectively measured adherence to oral appliance (OA) treatment may affect dental changes and temporomandibular disorders (TMD) in patients with obstructive sleep apnea (OSA).

Methods
The original study group consisted of adults with OSA who were referred for OA therapy. Eight indicators of subjective side effects of using OA (temporomandibular joint (TMJ) and muscle pain, pain in teeth, jaw stiffness in the morning, clicking, dry mouth, hypersalivation, gingival irritation) were evaluated by a questionnaire. Three occlusal indicators (overjet, overbite, molar occlusion) and clinical TMD signs (TMJ pain, muscle pain, clicking, jaw deviation on opening) were evaluated at baseline and at the 3-, 6-, and 12-month follow-up. In addition, objective adherence monitoring for OA was registered. Statistical analyses included the chi-square test, Fisher’s exact test, paired sample t-test, and linear regression analyses.

Results
A total of 58 adults with OSA were referred for OA therapy. Mean (SD) age was 50.7 (11.7) and mean apnea-hypopnea index (AHI) was 19.5 (10.0). At 1-year follow-up, the study group consisted of 28 men and 12 women. Overjet but not overbite reduced significantly after 1-year OA therapy. The average nightly wear of OA was related to overjet and overbite reduction, and to TMD signs. Hypersalivation, dry mouth, and tooth discomfort were the most common subjective side effects of OA therapy.

Conclusion
There was a time-dependent relationship with the nightly wear of OA and reduction in overjet and overbite, and clinical TMD signs. With 60% of mandibular advancement, dental changes and TM-disorders were considered mild/minor in the 1‐year study period.
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease
Authors: Srivastava Pranay , Nishiyama Shuhei , Zhou Fang , Lin Sonia H. , Srivastava Akriti , Su Chienwen , Xu Yuehang , Peng Weiyi , Levy Michael , Schwarzschild Michael , Chen Xiqun 
Published: December 2023

Abstract
Background
Melanocortin 1 receptor (MC1R) is a key pigmentation gene, and loss-of-function of MC1R variants that produce red hair may be associated with Parkinson’s disease (PD). We previously reported compromised dopaminergic neuron survival in Mc1r mutant mice and dopaminergic neuroprotective effects of local injection of a MC1R agonist to the brain or a systemically administered MC1R agonist with appreciable central nervous system (CNS) permeability. Beyond melanocytes and dopaminergic neurons, MC1R is expressed in other peripheral tissues and cell types, including immune cells. The present study investigates the impact of NDP-MSH, a synthetic melanocortin receptor (MCR) agonist that does not cross BBB, on the immune system and the nigrostriatal dopaminergic system in mouse model of PD.

Methods
C57BL/6 mice were treated systemically with MPTP.HCl (20 mg/kg) and LPS (1 mg/kg) from day 1 to day 4 and NDP-MSH (400 µg/kg) or vehicle from day 1 to day 12 following which the mice were sacrificed. Peripheral and CNS immune cells were phenotyped and inflammatory markers were measured. The nigrostriatal dopaminergic system was assessed behaviorally, chemically, immunologically, and pathologically. To understand the role of regulatory T cells (Tregs) in this model, CD25 monoclonal antibody was used to deplete CD25 + Tregs.

Results
Systemic NDP-MSH administration significantly attenuated striatal dopamine depletion and nigral dopaminergic neuron loss induced by MPTP + LPS. It improved the behavioral outcomes in the pole test. Mc1r mutant mice injected with NDP-MSH in the MPTP and LPS paradigm showed no changes in striatal dopamine levels suggesting that the NDP-MSH acts through the MC1R pathway. Although no NDP-MSH was detected in the brain, peripheral, NDP-MSH attenuated neuroinflammation as observed by diminished microglial activation in the nigral region, along with reduced TNF-α and IL1β levels in the ventral midbrain. Depletion of Tregs was associated with diminished neuroprotective effects of NDP-MSH.

Conclusions
Our study demonstrates that peripherally acting NDP-MSH confers protection on dopaminergic nigrostriatal neurons and reduces hyperactivated microglia. NDP-MSH modulates peripheral immune responses, and Tregs may be involved in the neuroprotective effect of NDP-MSH.
Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients
Authors: An Yang , Lu Wenyuan , Li Shijia , Lu Xiaoyan , Zhang Yuanyuan , Han Dongcheng , Su Dingyuan , Jia Jiaxin , Yuan Jiaxin , Zhao Binbin , Tu Mengjie , Li Xinyu , Wang Xiaoqing , Fang Na , Ji Shaoping 
Published: December 2023

AbstractProstate cancer (PC) is one of the most common cancers in men and becoming the second leading cause of cancer fatalities. At present, the lack of effective strategies for prognosis of PC patients is still a problem to be solved. Therefore, it is significant to identify potential gene signatures for PC patients’ prognosis. Here, we summarized 71 different prognostic gene signatures for PC and concluded 3 strategies for signature construction after extensive investigation. In addition, 14 genes frequently appeared in 71 different gene signatures, which enriched in mitotic and cell cycle. This review provides extensive understanding and integrated analysis of current prognostic signatures of PC, which may help researchers to construct gene signatures of PC and guide future clinical treatment.