bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a predictive model for early diagnosis of neonatal acute respiratory distress syndrome based on the Montreux definition
Authors: Shen Leilei , Cai Na , Wan Shaoyou , Chen Sheng 
Published: November 2023

ObjectiveBased on the Montreux definition, we aim to develop and validate a predictive model for the early diagnosis of neonatal acute respiratory distress syndrome (ARDS).MethodsA retrospective analysis of clinical data on 198 neonates with respiratory distress from January 2018 to January 2022 was conducted. Neonates meeting Montreux definition were classified as ARDS group (n = 79), while the rest were non-ARDS group (n = 119). Univariate analysis identified indicators for neonatal ARDS, followed by logistic regression to construct a predictive model for early diagnosis. The ability of predictors and models to predict neonatal ARDS was evaluated using area under the curve (AUC), and model performance was estimated through bootstrap resampling.ResultsMaternal prenatal fever, abnormal fetal heart beat, meconium-stained amniotic fluid (MSAF), white blood cell (WBC), absolute neutrophil count (ANC), neutrophil percentage (NE%), platelet count (PLT), C-reactive protein (CRP), procalcitonin (PCT), creatine kinase (CK), activated partial thromboplastin time (APTT), serum calcium (Ca) and sodium (Na)exhibited significant differences between the ARDS group and the non-ARDS group (P &lt; 0.05). MSAF (OR=5.037; 95% CI: 1.523–16.657; P &lt; 0.05), ANC (OR = 1.324; 95% CI: 1.172–1.495; P &lt; 0.05), PLT (OR = 0.979; 95% CI: 0.971–0.986; P &lt; 0.05), Ca (OR = 0.020; 95% CI: 0.004–0.088; P &lt; 0.05) emerged as independent risk factors for the development of ARDS. The respective AUC values for MSAF, ANC, PLT, Ca, and the combined prediction models were 0.606, 0.691, 0.808, 0.761 and 0.931. Internal validation showed that the C-index for the model was 0.931.ConclusionsEarly application of the model combining MSAF, ANC, PLT and Ca may have a good predictive effect on the early diagnosis of neonatal ARDS.
The anti-leukemia activity and mechanisms of shikonin: a mini review
Authors: Dong Han , Chang Chun-Di , Gao Fei , Zhang Na , Yan Xing-Jian , Wu Xue , Wang Yue-Hui 
Published: November 2023

Leukemia encompasses a group of highly heterogeneous diseases that pose a serious threat to human health. The long-term outcome of patients with leukemia still needs to be improved and new effective therapeutic strategies continue to be an unmet clinical need. Shikonin (SHK) is a naphthoquinone derivative that shows multiple biological function includes anti-tumor, anti-inflammatory, and anti-allergic effects. Numerous studies have reported the anti-leukemia activity of SHK during the last 3 decades and there are studies showing that SHK is particularly effective towards various leukemia cells compared to solid tumors. In this review, we will discuss the anti-leukemia effect of SHK and summarize the underlying mechanisms. Therefore, SHK may be a promising agent to be developed as an anti-leukemia drug.
Home-administered transcranial direct current stimulation with asynchronous remote supervision in the treatment of depression: feasibility, tolerability, and clinical effectiveness
Authors: Koutsomitros Theodoros , Schwarz Sandra A. , van der Zee Kenneth T. , Schuhmann Teresa , Sack Alexander T. 
Published: November 2023

Introduction (Background)Depression is an often chronic condition, characterized by wide-ranging physical, cognitive and psychosocial symptoms that can lead to disability, premature mortality or suicide. It affects 350 million people globally, yet up to 30% do not respond to traditional treatment, creating an urgent need for novel non-pharmacological treatments. This open-label naturalistic study assesses the practical feasibility, tolerability, and clinical effectiveness of home-administered transcranial direct current stimulation (tDCS) with asynchronous remote supervision, in the treatment of depression.MethodOver the course of 3 weeks, 40 patients with depression received psychotherapy and half of this group also received daily bi-frontal tDCS stimulation of the dorsolateral prefrontal cortex. These patients received tDCS for 30 min per session with the anode placed over F3 and the cathode over F4, at an intensity of 2 mA for 21 consecutive days. We measured patients' level of depression symptoms at four time points using the Beck Depression Inventory, before treatment and at 1-week intervals throughout the treatment period. We monitored practical feasibility such as daily protocol compliance and tolerability including side effects, with the PlatoScience cloud-based remote supervision platform.ResultsOf the 20 patients in the tDCS group, 90% were able to comply with the protocol by not missing more than three of their assigned sessions, and none dropped out of the study. No serious adverse events were reported, with only 14 instances of mild to moderate side effects and two instances of scalp pain rated as severe, out of a total of 420 stimulation sessions. Patients in the tDCS group showed a significantly greater reduction in depression symptoms after 3 weeks of treatment, compared to the treatment as usual (TAU) group [t(57.2) = 2.268, p = 0.027]. The tDCS group also showed greater treatment response (50%) and depression remission rates (75%) compared to the TAU group (5 and 30%, respectively).Discussion (Conclusion)These findings provide a possible indication of the clinical effectiveness of home-administered tDCS for the treatment of depression, and its feasibility and tolerability in combination with asynchronous supervision.
An individual-supported program to enhance placement in a sheltered work environment of autistic individuals mostly with intellectual disability: a prospective observational case series in an Italian community service
Authors: Maggio Roberta , Turriziani Laura , Campestre Caterina , Di Cara Marcella , Tripodi Emanuela , Impallomeni Caterina , Quartarone Angelo , Passantino Claudio , Cucinotta Francesca 
Published: November 2023

IntroductionAutism spectrum disorder is a lifelong neurodevelopmental disorder. The profile of functioning in autistic people is very heterogeneous, and it is necessary to take into account individual characteristics to better support integration in the workplace. However, unemployment rates are higher for autistic people than for other types of disabilities. We present a prospective case series to explore the feasibility and efficacy of an individual-supported program to enhance placement in a sheltered work environment delivered by an Italian community day care center.MethodsAutistic subjects, aged from 12 to 31 years, participated in an individual-supported program regarding employment in sheltered art workshops, integrated into the regular activity of a semi-residential center three times a week for 1 year. Their feasibility retention rate and time worked per session were registered; moreover, working methods efficacy and self-organization improvement were tracked by the Likert-based rating system. Secondary outcome measures span functional levels, challenge behaviors, and sensory problems.ResultsAll the individuals presented a good adaptation to the environment, with a significant increase in time worked per session. After 1 year, the intervention allowed an increase in tasks completed in an assigned complex job and an improvement in self-organization within the work schedule in a group of subjects consisting mainly of severe-to-moderate levels of autism severity (86.6%). Finally, we observed a significant increase in independent functioning areas of the TEACCH transitional assessment profile. Challenge behaviors and sensory problems were also recorded.ConclusionThis case series supports the idea that individual-supported programs for placement in sheltered job environments delivered by community day care centers could be feasible and effective for ASD with higher levels of severity and co-occurring intellectual disability. Further targeted studies based on community models and accessible methods need to be planned to define the effectiveness of the intervention and promote improved practice at the community level with a better social impact.
Engaging interested parties to optimize wildfire smoke communication in Canada: challenges with initiating change
Authors: Choy Amelia , Shellington Erin M. , Rideout Karen , Roushorne Meghan , Joshi Phalgun , Carlsten Christopher 
Published: November 2023

BackgroundIn February 2022, an online Wildfire Smoke Communication Workshop series identified priorities and strategies to improve wildfire smoke communication in Canada. We evaluated the engagement methods, the workshop series and workshop summary report, to determine if participants/organizations initiated changes identified in the workshop to optimize wildfire smoke communication plans.MethodsThree evaluation surveys were developed using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework dimensions and PRISM (Practical, Robust, Implementation, and Sustainability Model) contextual domains to measure the engagement impact. Surveys 1, 2, and 3 were disseminated to workshop participants between February 2022 (post-workshop series), May 2022 (pre-wildfire season), and September 2022 (post-wildfire season). Likert survey responses were analyzed descriptively using means and standard deviations. Open-ended written responses were analyzed using deductive reasoning and response proportions.ResultsOf 69 workshop participants, 28, 19, and 13 responded to surveys 1, 2, and 3, respectively. Workshop participation helped survey 1 respondents consider optimizing wildfire smoke communication (M = 3.93, SD = 0.88). Workshop participation and the summary report helped survey 2 respondents consider new actions to optimize wildfire smoke communication (M = 3.84, SD = 0.74). The most intended action in survey 2 (68%, n = 13) and the most common action taken in survey 3 (62%, n = 8) was to simplify message content. The primary limitation to optimization was capacity.ConclusionThe engagement methods, particularly the summary report, were beneficial for organizations to take action to optimize wildfire smoke communication in Canada. Future engagement methods should examine persisting system-level issues and capacity limitations as they undermine the ability to optimize wildfire smoke communication in Canada.
Ultrahigh molecular weight polyethylene-reduced graphene oxide composite scaling up to produce wear resistant plates
Authors: Amurin Leice Gonçalves , Oliveira Poliane Neves De , Pereira Ana Flávia Tavares S. , Ribeiro Nirvana Cecília , Rezende Daniel Bastos De , Silva Glaura Goulart 
Published: November 2023

Maintaining the properties of nanocomposites obtained at the laboratory scale when evolving to pilot and industrial scales is a great challenge. In this work, the route for a 3000-fold increase in scale between the laboratory and production in an industrial environment was conducted in two stages–Pilot 1 and Pilot 2–to obtain polymeric nanocomposite plates for pilot testing. The nanocomposite was based on ultrahigh molecular weight polyethylene (UHMWPE) and reduced graphene oxide (rGO), and several different operations were optimized for complete scale-up, i.e., 1) production of reduced graphite oxide (rGrO); 2) exfoliation of rGrO; 3) milling of rGO with UHMWPE in a ball mill to produce masterbatch; and 4) RAM extrusion to produce the plates. All these steps were accompanied by characterizations that show the quality of the nanomaterial, masterbatch and nanocomposite plates. The gains in nanocomposite properties with 0.25 wt% rGO with respect to UHMWPE were ∼45% in elastic modulus, ∼50% in hardness, ∼25% in impact strength and 15% in abrasion wear (two-body test). The nanocomposite surfaces after wear tests are more hydrophobic than UHWWPE. The Pilot 1 results were generally superior to the Pilot 2 results, probably due to the very different thicknesses of the plates, i.e., 10 mm in Pilot 1 and 40 mm in Pilot 2. The improvement in different properties confirms the multifunctionality of the nanocomposite UHMWPE/rGO now produced on a pilot scale.
Effects of fermented feed on growth performance, serum biochemical indexes, antioxidant capacity, and intestinal health of lion-head goslings
Authors: Fu Zhiqi , Ao Na , Liang Xiaoen , Chen Jinhuang , Wang Yuchuan , Wang Qing , Fu Jing , Liu Chunpeng , Lu Lizhi 
Published: November 2023

IntroductionThe aim of this study was to evaluate the effects of fermented feed on growth performance, antioxidant indexes and intestinal health in lion-head goslings.Methods288 male lion-head goslings (one-day-old) were randomly divided into four groups (6 replicates per group, 12 samples per replicate): control group (basal diet) and fermented feed (FF) groups (basal diet supplemented with 2.5, 5.0 and 7.5% FF, respectively). The experimental period lasted 28 days.ResultsThe results showed that 5.0 and 7.5% FF groups decreased feed conversion rate (FCR) when compared with the control group (p &lt; 0.05). The 5.0% FF group reduced the activity of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum; while the 7.5% FF group decreased the concentration of total cholesterol (TC), ALP and LDH activity (p &lt; 0.05). Furthermore, the 7.5% FF group significantly increased total antioxidant capacity (T-AOC) in serum (p &lt; 0.05); 2.5% and 5.0% FF groups significantly increased glutathione peroxidase (GSH-Px) in serum (p &lt; 0.05); all FF groups increased the activity of superoxide dismutase (T-SOD) in serum (p &lt; 0.05). For intestinal health, the villous height and villi/crypt ratio in jejunum were increased in all FF groups, but crypt depth was decreased (p &lt; 0.05); The 5.0% FF groups enhanced T-AOC activity in jejunum (p &lt; 0.05); The 2.5% and 5.0% FF groups enhanced GSH-Px activity (p &lt; 0.05) in jejunum; All FF groups reduced malondialdehyde (MDA) level in jejunum (p &lt; 0.05). LEfSe analysis showed that the cecum microbiota was significantly dominant in the 2.5% FF group compared to the control group including Firmicutes, Lactobacillales, Lactobacillus, and Prevotella; the flora that were significantly dominant in the 5.0% FF group compared to the control group included Bacteroidaceae, Bacteroides, Megamonas, and Prevotella; and the groups that were significantly dominant in the 7.5% FF group compared to the control group included Bacteroidota, Bacteroides, Bacteroidaceae, and Ruminococcaceae.DiscussionIn summary, dietary FF supplementation improved growth performance, serum biochemical parameters and antioxidant capacity of lion-head goslings, as well as improved jejunal tissue morphology and optimized intestinal flora structure. In particular, the FF addition at a dose of 7.5% was relatively more effective for lion- head goslings.
Development of a shared item repository for progress testing in veterinary education
Authors: Schaper Elisabeth , van Haeften Theo , Wandall Jakob , Iivanainen Antti , Penell Johanna , Press Charles McLean , Lekeux Pierre , Holm Peter 
Published: November 2023

IntroductionProgress testing in education is an assessment principle for the measurement of students’ progress over time, e.g., from start to graduation. Progress testing offers valid longitudinal formative measurement of the growth in the cognitive skills of the individual students within the subjects of the test as well as a tool for educators to monitor potential educational gaps and mismatches within the curriculum in relation to the basic veterinary learning outcomes.MethodsSix veterinary educational establishments in Denmark, Finland, Germany (Hannover), the Netherlands, Norway, and Sweden established in cooperation with the European Association of Establishments for Veterinary Education (EAEVE) a common veterinary item repository that can be used for progress testing in European Veterinary Education Establishments (VEEs), linear as well as computer adaptive, covering the EAEVE veterinary subjects and theoretical “Day One Competencies.” First, a blueprint was created, suitable item formats were identified, and a quality assurance process for reviewing and approving items was established. The items were trialed to create a database of validated and calibrated items, and the responses were subsequently psychometrically analyzed according to Modern Test Theory.ResultsIn total, 1,836 items were submitted of which 1,342 were approved by the reviewers for trial testing. 1,119 students from all study years and all partners VEEs participated in one or more of six item trials, and 1,948 responses were collected. Responses were analyzed using Rasch Modeling (analysis of item-fit, differential item function, item-response characteristics). A total of 821 calibrated items of various difficulty levels matching the veterinary students’ abilities and covering the veterinary knowledge domains have been banked.DiscussionThe item bank is now ready to be used for formative progress testing in European veterinary education. This paper presents and discusses possible pitfalls, problems, and solutions when establishing an international veterinary progress test.
EFFECT OF THE EXISTENCE OF PANGSAN TOURISM VILLAGE ON CHANGES IN LAND USE, ECONOMIC, AND SOCIAL COMMUNITIES
Authors: Adi Husnaini  
Published: November 2023

Tourism is one of the main sectors in Indonesia to improve the economy. The strategy in developing the economy, especially in rural areas, is to develop tourism villages. As one of the sectors that occupy space development, directly or indirectly, will affect changes in economic conditions, social and physical geography. Pangsan Village is located in Petang District, Badung Regency. The development of this tourism village is certainly an impact on the physical and non- physical conditions in the village. Based on this statement, this study was conducted to assess the influence of Pangsan Tourism Village existence toward land-use changing, economic and social. The method used in this study is Descriptive quantitative method. These results indicate that the presence of Pangsan Tourism Village affects changes in land use where forests and rice fields are used as tourist attractions to support tourism activities. The existence of the tourism village also has an effect on the economy, especially the expansion of job opportunities and increased revenues. The developments of a tourism village with many tourists who come also affect social conditions that are reflected in the patterns of behavior and attitude of people skills. As for the distribution of increased community skills gained from training for manage the tourism village. The results of the research are expected to be a guideline for stakeholders to develop Pangsan Tourism Village
Keywords: Tourism Village, Land-Use Change, Economic, Social
Université de Paris V. Des moniteurs d’«alphabétisation» en stage à Paris V
Authors: Charlot Martine 
Published: November 2023

Depuis 1973, à l’initiative de l’U. E. R. de Linguistique générale et appliquée et sous l’égide du Centre de Formation Continue de l’Université René-Descartes (Paris V), sont organisés des stages de formation de moniteurs d’ «alphabétisation » (1).
Les stages se déroulent selon la formule des stages intensifs (deux semaines à plein temps) ou celle des stages extensifs (tous les samedis matin durant l’année universitaire).
Nous présentons ici quelques-uns des stagiaires du stage extensif de 1976-1977.
La formation des formateurs de travailleurs migrants : Par qui ? Pour qui ? Comment ? Pourquoi ?
Authors: Charlot Martine 
Published: November 2023

Nous rappellerons ici les options énoncées dans l’éditorial pour la présentation de l’aspect institutionnel de la formation des formateurs :
1) Large extension donnée au concept de formateur, englobant les formateurs de formateurs, moniteurs de cours de langue ou de cours professionnel, travailleurs sociaux, directeurs et animateurs de Foyers, agents «intermédiaires » et du Réseau National d’Accueil, etc.
2) Informations apportées par les directeurs ou responsables d’administrations et d’organismes. Cette option avait pour but de faire connaître des discours «officiels » afin de permettre d’une part une confrontation entre eux, révélatrice ou non de leurs convergence et cohérence au niveau de l’analyse et des objectifs poursuivis ; d’autre part, une élaboration par les formateurs de base et les formés de leur propre discours sur la formation.
Un stage de formation d'enseignants italiens en France
Authors:   CEFISEM de Lyon
Published: November 2023

Les C.E.F.I.S.E.M. (Centres de Formation et d’information pour la scolarisation des enfants de migrants) organisent régulièrement, entre autres, des stages pour les enseignants étrangers exerçant en France à l’école élémentaire dans le cadre de la circulaire du 9 avril 1975.
Nous reproduisons ici des fragments du compte rendu d’un stage organisé du 4 au 8 décembre 1978 par le C.E.F.I.S.E.M. de Lyon à la demande de l’Ambassade d’Italie en France pour une trentaine d’instituteurs et institutrices italiens.
Analisis Perbandingan Perilaku Struktur Dengan Variasi Bentuk Penampang Kolom Beton Bertulang
Authors: Fachri  , Deded Eka Sahputra  , Asri Yuda Trinanda  , Rafki Imani  
Published: November 2023

Penampang kolom adalah salah satu elemen penting dalam desain struktur beton bertulang. Berbagai bentuk penampang dapat digunakan, seperti persegi, persegi panjang, lingkaran, atau bentuk khusus lainnya. Setiap bentuk penampang memiliki karakteristik yang berbeda dalam hal kekuatan, kekakuan, dan perilaku ketika terkena beban. dilakukan analisis komparatif terhadap beberapa variasi bentuk penampang kolom beton bertulang. Metode analisis dinamik dan Perangkat lunak analisis struktur digunakan untuk mensimulasikan perilaku struktur dengan berbagai bentuk penampang. Parameter seperti beban maksimum yang dapat ditahan, deformasi struktural, dan gaya dalam kolom dievaluasi dan dibandingkan. Hasil penelitian didapatkan nilai simpangan arah X paling kecil dengan rasio 9,08% dari kolom persegi dan 0,84% terhadap kolom lingkaran Simpangan arah-Y nilai paling kecil terjadi pada struktur dengan kolom lingkaran dengan rasio 15,15% terhadap kolom persegi panjang dan 7,40% terhadap kolom persegi. Nilai gaya geser arah X pada kolom persegi memiliki rasio 5,07% terhadap kolom lingkaran dan 6,2% terhadap kolom persegi panjang. Nilai gaya geser arah Y pada kolom persegi panjang memiliki rasio 15,5% terhadap kolom lingkaran dan 6,8% terhadap kolom persegi. Gaya momen arah Y pada kolom persegi panjang memiliki rasio 12,76% terhadap kolom lingkaran dan 7,66% terhadap kolom persegi, pada gaya momen arah X kolom persegi memiliki rasio 6,52% terhadap kolom lingkaran dan 7,5% terhadap kolom persegi panjang