bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emerging Landscape for Combating Resistance Associated with Energy‐Based Therapies via Nanomedicine
Authors: Hu Qitao , Zuo Huali , Hsu Jessica C. , Zeng Cheng , Tian Zhou , Sun Zhouyi , Cai Weibo , Tang Zhe , Chen Weiyu 
Published: November 2023

AbstractCancer represents a serious disease with significant implications for public health, imposing substantial economic burden and negative societal consequences. Compared to conventional cancer treatments, such as surgery and chemotherapy, energy‐based therapies (ET) based on athermal and thermal ablation provide distinct advantages, including minimally invasive procedures and rapid postoperative recovery. Nevertheless, due to the complex pathophysiology of many solid tumors, the therapeutic effectiveness of ET is often limited. Nanotechnology offers unique opportunities by enabling facile material designs, tunable physicochemical properties, and excellent biocompatibility, thereby further augmenting the outcomes of ET. Numerous nanomaterials have demonstrated the ability to overcome intrinsic therapeutic resistance associated with ET, leading to improved antitumor responses. This comprehensive review systematically summarizes the underlying mechanisms of ET‐associated resistance (ETR) and highlights representative applications of nanoplatforms used to mitigate ETR. Overall, this review emphasizes the recent advances in the field and presents a detailed account of novel nanomaterial designs in combating ETR, along with efforts aimed at facilitating their clinical translation.
High‐Reversibility Sulfur Anode for Advanced Aqueous Battery
Authors: Chen Qianru , Hao Junnan , Zhang Shaojian , Tian Zhihao , Davey Kenneth , Qiao Shi‐Zhang 
Published: November 2023

AbstractDespite being extensively explored as cathodes in batteries, sulfur (S) can function as a low‐potential anode by changing charge carriers in electrolytes. Here, a highly reversible S anode that fully converts from S80 to S2− in static aqueous S–I2 batteries by using Na+ as the charge carrier is reported. This S anode exhibits a low potential of −0.5 V (vs standard hydrogen electrode) and a near‐to‐theoretical capacity of 1404 mA h g−1. Importantly, it shows significant advantages over the widely used Zn anode in aqueous media by obviating dendrite formation and H2 evolution. To suppress “shuttle effects” faced by both S and I2 electrodes, a scalable sulfonated polysulfone (SPSF) membrane is proposed, which is superior to commercial Nafion in cost (US$1.82 m−2 vs $3500 m−2) and environmental benignity. Because of its ultra‐high selectivity in blocking polysulfides/iodides, the battery with SPSF displays excellent cycling stability. Even under 100% depth of discharge, the battery demonstrates high capacity retention of 87.6% over 500 cycles, outperforming Zn–I2 batteries with 3.1% capacity under the same conditions. These findings broaden anode options beyond metals for high‐energy, low‐cost, and fast‐chargeable batteries.
Correlating Single‐Atomic Ruthenium Interdistance with Long‐Range Interaction Boosts Hydrogen Evolution Reaction Kinetics
Authors: Jiang Bowen , Zhu Jiawei , Xia Zhenzhi , Lyu Jiahui , Li Xingchuan , Zheng Lirong , Chen Cheng , Chaemchuen Somboon , Bu Tongle , Verpoort Francis , Mu Shichun , Wu Jinsong , Wang John , Kou Zongkui 
Published: November 2023

AbstractCorrelated single‐atom catalysts (c‐SACs) with tailored intersite metal–metal interactions are superior to conventional catalysts with isolated metal sites. However, precise quantification of the single‐atomic interdistance (SAD) in c‐SACs is not yet achieved, which is essential for a crucial understanding and remarkable improvement of the correlated metal‐site‐governed catalytic reaction kinetics. Here, three Ru c‐SACs are fabricated with precise SAD using a planar organometallic molecular design and π–π molecule–carbon nanotube confinement. This strategy results in graded SAD from 2.4 to 9.3 Å in the Ru c‐SACs, wherein tailoring the Ru SAD into 7.0 Å generates an exceptionally high turnover frequency of 17.92 H2 s−1 and a remarkable mass activity of 100.4 A mg−1 under 50 and 100 mV overpotentials, respectively, which is superior to all the Ru‐based catalysts reported previously. Furthermore, density functional theory calculations confirm that Ru SAD has a negative correlation with its d‐band center owing to the long‐range interactions induced by distinct local atomic geometries, resulting in an appropriate electrostatic potential and the highest catalytic activity on c‐SACs with 7.0 Å Ru SAD. The present study promises an attractive methodology for experimentally quantifying the metal SAD to provide valuable insights into the catalytic mechanism of c‐SACs.
Blue Light‐Promoted Synthesis of Thiochromenopyrroledione Derivatives via Titanium Dioxide‐Catalyzed Dual Carbon–Carbon Bond Formation with Thioanisole and Maleimide Derivatives
Authors: Kanti Roy Pijush , Okunaka Sayuri , Tokudome Hiromasa , Hitomi Yutaka 
Published: November 2023

AbstractUnder anaerobic conditions, thioanisole derivatives bearing a thiomethyl group participated in dual carbon‐carbon bond‐forming reactions with maleimide derivatives in the presence of titanium dioxide. Blue light irradiation facilitated these reactions, producing thiochromenopyrroledione derivatives and nearly equimolar quantities of succinimide derivatives. Specifically, a thiochromenopyrroledione derivative formed from thioanisole and N‐benzylmaleimide was achieved with a 43% yield after 12 hours of blue light exposure (>420 nm), approaching its theoretical maximum yield of 50%. Without titanium dioxide, the reaction remained dormant. Our investigations with five varieties of 4‐substituted thioanisoles and four N‐substituted maleimides as precursors resulted in the synthesis of 20 distinct thiochromenopyrroledione derivatives with moderate to high yields. From observed substituent effects, we postulate that this reaction proceeds through a charge transfer from thioanisole to the conduction band of titanium dioxide during blue light irradiation, initiating the one‐electron oxidation of thioanisole and subsequent generation of α‐thioalkyl radicals via deprotonation.
Palladium‐Catalyzed S‐Allylation of Vinyl Carbinols – Total Syntheses of Carotenoids by Julia‐Kocienski Olefination
Authors: Golikov Aleksei N. , Seo Chibeom , Hwan Lee Jae , Koo Sangho 
Published: November 2023

AbstractPalladium catalyzed S‐allylation of vinyl carbinols from ionones (or conjugated carbonyls) with 2‐mercapto‐1,3‐benzothiazole (BT‐SH) provides versatile C15 dienyl benzothiazolyl (BT) sulfides. This Pd(dppe)Cl2‐catalyzed S‐allylation is highly selective for free allylic alcohols in the presence of allylic acetates, resulting in 3‐ or 4‐acetoxy C15 dienyl BT‐sulfides suitable for xanthophyll synthesis. The corresponding C15 dienyl BT‐sulfones undergo Julia‐Kocienski olefination reactions with C10 2,7‐dimethyl‐2,4,6‐octatrienedial under mild conditions to produce carotenoids natural products. Efficient synthesis is achieved for a range of carotenoids including xanthophylls such as iso‐zeaxanthin, zeaxanthin, and lutein as well as carotenes like β‐carotene, ϵ‐carotene, and 9′‐Z‐phenyl‐carotene.
Activity Restoration of Pt–Ni Octahedron via Phase Recovery for Anion Exchange Membrane‐Unitized Regenerative Fuel Cells
Authors: Oh Cheoulwoo , Han Man Ho , Ko Young‐Jin , Cho Jun Sik , Pin Min Wook , Strasser Peter , Choi Jae‐Young , Kim Hansung , Choi Chang Hyuck , Lee Woong Hee , Oh Hyung‐Suk 
Published: November 2023

AbstractUnitized regenerative fuel cells (URFCs) offer a cost‐effective solution for energy conversion by functioning as both fuel cells and electrolyzers. Anion‐exchange membrane‐based URFCs (AEM‐URFCs) require bifunctional electrocatalysts, such as Pt–Ir alloys, for the oxygen evolution reaction (water electrolysis mode) and oxygen reduction reaction (fuel cell mode). However, the low stability of Pt in alkaline media and the high cost of Ir remain challenges for the widespread application of these URFCs. In this study, a Pt–Ni octahedral alloy is synthesized to replace Ir with Ni as the oxygen evolution reaction catalyst. The alloying effect of Pt–Ni inhibits the dissolution of Pt and transforms PtOx to metallic Pt via a recovery process, thereby providing a new operational strategy for improving the durability of AEM‐URFCs. Remarkably, the performance of the AEM‐URFC single cell is maintained over ten cycles after the recovery process, demonstrating the viability of this approach for long‐term operations. These findings pave the way for broader applications and advancements of AEM‐URFCs.
Hierarchically Multiscale Vertically Oriented NiFeCo Nanoflakes for Efficient Electrochemical Oxygen Evolution at High Current Densities
Authors: Riaz Asim , Fusco Zelio , Kremer Felipe , Gupta Bikesh , Zhang Doudou , Jagadish Chennupati , Tan Hark Hoe , Karuturi Siva 
Published: November 2023

AbstractCrucial advancements in versatile catalyst systems capable of achieving high current densities under industrial conditions, bridging the gap between fundamental understanding and practical applications, are pivotal to propel the hydrogen economy forward. In this study, vertically oriented hierarchically multiscale nanoflakes of NiFeCo electrocatalysts are presented, developed by surface modification of a porous substrate with nano‐structured nickel. The resulting electrodes achieve remarkably low overpotentials of 139 mV at 10 mAcm−2 and 248 mV at 500 mAcm−2. Further, scaled‐up electrodes are implemented in a water‐splitting electrolyser device exhibiting a stable voltage of 1.82 V to deliver a constant current density of 500 mA cm−2 for over 17 days. Moreover, the role of the unique structures on electrochemical activity is systematically investigated by fractal analysis, involving computation of structure factors such as Minkowski connectivity, fractal dimension, and porosity using scanning electron microscope images. It is found that such structures offer higher surface area than typical layered double hydroxide structures due to morphological coherence that results in a superhydrophilic surface, while the base Ni layer boosts the charge transfer. This study demonstrates a Ni/NiFeCo(OH)x heterostructure with highly porous morphology, a key to unlocking extremely efficient oxygen evolution reaction activity with exceptional stability. Moreover, fractal analysis is presented as a valuable tool to evaluate the electrochemical performance of catalysts for their structured morphology.
Then and now: A 50‐year retrospective thematic analysis of Society for Community Research and Action presidential addresses
Authors: Nettles Christopher D. , Schlehofer Michèle M. , Buckingham Sara L. , Brookins Craig (Kwesi) , Flores Yvette G. , Kelly Amber E. 
Published: November 2023

AbstractThe Society for Community Research and Action (SCRA) is the primary professional home for community psychologists in the United States and increasingly around the world. Since the formation of the American Psychological Association Division 27: Community Psychology in 1966, now SCRA, 54 people have served in the Presidential role. Presidential leaders' annual addresses both reflect the current state of the field and have the ability to shape the future of both SCRA as an organization and community psychology as a discipline given their positions as leaders. This commentary explores the trajectory of SCRA as an organization via 33 available presidential addresses, 28 of which were published in the American Journal of Community Psychology (AJCP). Using thematic analysis and drawing on both dialectical and life cycle organizational processes, three periods of SCRA and community psychology more broadly were identified: defining community psychology, applying community psychology, and re‐imagining community psychology. Themes speak to tensions between the ideals of the society and the work of the society. We conclude by offering a series of questions for consideration as SCRA positions itself for the future.
Ambient Phosphor with High Efficiency and Long Lifetime in Poly(Methyl Methacrylate) Through Charge‐Transfer‐Mediated Triplet Exciton Formation for Photolithography Applications
Authors: Liu Ruyi , Liu Chuanhao , Fu Caixia , Zhu Zhenzhen , Chen Kuan , Li Chuan , Wang Lingjie , Huang Yan , Lu Zhiyun 
Published: November 2023

AbstractCurrently, purely organic compounds showing ambient phosphorescence with high efficiency (ΦP) and ultra‐long lifetime (τP) are quite rare and often need to be achieved in hydrophilic poly(vinyl alcohol)‐based hosts. This severely limits their applications. Here, we provide a solution to this issue by constructing an ortho‐linked donor‐acceptor (D−A) dyad whose D moiety has not only a long‐lived T1 state to achieve a long τP, but also a Tn state that is close to the S1 state of the dyad to trigger effective spin‐orbit charge transfer intersystem crossing (SOCT‐ISC). The rationality of this strategy was validated by a new phosphor OF‐BCz that is able to show a τP of 1.92 s and a ΦP of 30 % even in a less rigid matrix of poly(methyl methacrylate) (PMMA). Excitingly, OF‐BCz exhibited its potential as both a photocuring initiator and an in situ quality indicator, allowing for the visual detection of defects in photolithographic patterning.
Rhodium(I)‐Catalyzed Asymmetric Hydroarylative Cyclization of 1,6‐Diynes to Access Atropisomerically Labile Chiral Dienes
Authors: Hu Panjie , Hu Lingfei , Li Xiao‐Xi , Pan Mengxiao , Lu Gang , Li Xingwei 
Published: November 2023

AbstractAxially chiral open‐chained olefins are an underexplored class of atropisomers, whose enantioselective synthesis represents a daunting challenge due to their relatively low racemization barrier. We herein report rhodium(I)‐catalyzed hydroarylative cyclization of 1,6‐diynes with three distinct classes of arenes, enabling highly enantioselective synthesis of a broad range of axially chiral 1,3‐dienes that are conformationally labile (ΔG≠(rac)=26.6–28.0 kcal/mol). The coupling reactions in each category proceeded with excellent enantioselectivity, regioselectivity, and Z/E selectivity under mild reaction conditions. Computational studies of the coupling of quinoline N‐oxide system reveal that the reaction proceeds via initial oxidative cyclization of the 1,6‐diyne to give a rhodacyclic intermediate, followed by σ‐bond metathesis between the arene C−H bond and the Rh−C(vinyl) bond, with subsequent C−C reductive elimination being enantio‐determining and turnover‐limiting. The DFT‐established mechanism is consistent with the experimental studies. The coupled products of quinoline N‐oxides undergo facile visible light‐induced intramolecular oxygen‐atom transfer, affording chiral epoxides with complete axial‐to‐central chirality transfer.
Evidence of gel effect and living free radicals in particles: Soap‐free emulsion polymerization of styrene by using 2,2'‐azobis(isobutyronitrile)
Authors: Zhu Bing , Ni Henmei 
Published: November 2023

AbstractBatch, in situ seeded and stepwise dosing monomer, and normal seeded soap‐free emulsion polymerizations (SFEP) of styrene were carried out by using the oil‐soluble 2,2′‐azobis(isobutyronitrile) as initiator. Gel permeation chromatography (GPC) and scanning electron microscopy were employed to characterize the experimental results. Typical auto‐accelerative effect in the bulk free‐radical polymerization was also observed in the macro‐kinetics of batch SFEP at 60 and 65°C. Flat‐roof GPC curves appeared at the post‐auto‐acceleration. In addition, in particles exhibited a positive relationship with the size of particles. The bigger size the larger . In the in situ seeded polymerization, the flat‐roof GPC curves of seed turned into the asymmetric Gaussian type exhibiting the great increase of the fraction of larger with the sequential addition of styrene. In addition, the number of seeds was kept constant throughout the polymerization. It indicated that the free radicals were generated and confined in the growing particles. In the normal seeded polymerization, showed a strong dependence on the average assigned amount of St per seed particle. The more monomers per seed particle the larger was gained. Based on these results, it was postulated that the free radicals were living due to the gel effect occurring in particles, namely that the free radicals were segregated by the dry polymer chains. The kinetics model was also given based on the microdroplets theory.
A saurischian (Archosauria, Dinosauria) ilium from the Upper Triassic of southern Brazil and the rise of Herrerasauria
Authors: Garcia Mauricio Silva , Cabreira Sérgio Furtado , da Silva Lúcio Roberto , Pretto Flávio Augusto , Müller Rodrigo Temp 
Published: November 2023

AbstractThe Carnian (Upper Triassic) rocks of the Candelária Sequence present a rich record of dinosaurs, including some of the oldest known dinosaurs worldwide. In this contribution we describe the first unequivocal dinosaur from the Pivetta site, located in the Restinga Sêca municipality, Southern Brazil. The specimen CAPPA/UFSM 0373 is an isolated but well‐preserved left ilium. A thorough examination of the specimen's anatomy and a phylogenetic analysis provides evidence that CAPPA/UFSM 0373 belongs to the Herrerasauria. We were able to identify several similarities with potential non‐herrerasaurid herrerasaurians (e.g., Tawa hallae, “Caseosaurus crosbyensis”), which were previously only known from North American deposits. In contrast, herrerasaurids (e.g., Herrerasaurus ischigualastensis) are almost exclusively known from South America. Our results support the nesting of CAPPA/UFSM 0373 as an early‐diverging herrerasaurian. Furthermore, this is potentially the first record of a non‐herrerasaurid herrerasaurian in unambiguous Carnian beds, suggesting a hidden diversity of dinosaurs in the Carnian rocks of the Candelária Sequence, which can be revealed even by fragmentary specimens.
Information practices in data analytics for supporting public health surveillance
Authors: Zhang Dan , Pee Loo G. , Pan Shan L. , Wang Jingyuan 
Published: November 2023

AbstractPublic health surveillance based on data analytics plays a crucial role in detecting and responding to public health crises, such as infectious disease outbreaks. Previous information science research on the topic has focused on developing analytical algorithms and visualization tools. This study seeks to extend the research by investigating information practices in data analytics for public health surveillance. Through a case study of how data analytics was conducted for surveilling Influenza A and COVID‐19 outbreaks, both exploration information practices (i.e., probing, synthesizing, exchanging) and exploitation information practices (i.e., scavenging, adapting, outreaching) were identified and detailed. These findings enrich our empirical understanding of how data analytics can be implemented to support public health surveillance.
Post‐secondary vocational education for youth leaving care: Examining a potential pathway to successful outcomes
Authors: Collins Mary Elizabeth , Augsberger Astraea , Howard Riana 
Published: November 2023

AbstractPost‐secondary educational outcomes for care‐experienced youth are poor. This has been a consistent finding across studies in many countries. Most studies do not distinguish between different types of post‐secondary educational pathways and outcomes, however. There has been limited attention to the potential for post‐secondary vocational education (PSVE) as a viable educational path that may lead to positive employment and social outcomes. In this paper we examine PSVE for care leavers by reviewing available data, examining policy context and utilising relevant theories. We offer next steps in policy, practice and theory development.
Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic Escherichia Coli
Authors: Pylkkö Tuomas , Tomašič Tihomir , Poso Antti , Tammela Päivi 
Published: November 2023

AbstractThis study aimed to identify inhibitors of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC). EPEC is an intestinal pathogen that causes diarrhea and is a major health concern worldwide. Because Tir is a key virulence factor involved in EPEC pathogenesis, inhibiting its function is a potential strategy for controlling EPEC infections. Virtual screening was applied to chemical libraries to search for compounds that inhibit Tir‐mediated bacterial adherence to host cells. Three sites were targeted using the cocrystal structure published earlier. A selection of compounds was then assessed in a cell‐based infection model and fluorescence microscopy assay. The results of this study provide a basis for further optimization and testing of Tir inhibitors as potential therapeutic agents for EPEC infections.
Recurrent left ischemic stroke in a patient with systemic lupus erythematosus: A case report
Authors: Aryal Ananda , Aryal Anita , Kshetri Dipika , Karki Sagun , Khadka Sabina 
Published: November 2023

Key Clinical MessageSome studies have manifested the relationship between SLE and stroke. Therefore, it is very important to pay close attention to the diagnosis of SLE in recurring stroke. In our case, her recurrent stroke attack might be due to the undiagnosed cause of SLE.AbstractAn ischemic stroke is a medical emergency condition which occurs when blood supply to part of the brain is blocked. Early action is needed; therefore, time is crucial. SLE is an autoimmune disease with multiple joint pain, fever, rashes, and organ damage. We report an old lady who was recently diagnosed with SLE with multiple stroke attack. Although she was diagnosed with SLE much later there was a suspicious about the possible mechanism for her recurrent ischemic stroke. She was given antiplatelet, antiepileptic, antihypertensive, and hydroxychloroquine medicines for the treatment. The neurological symptoms improved only after we provided physiotherapy.
An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase**
Authors: Lee Joel H. Z. , Bruning John B. , Bell Stephen G. 
Published: November 2023

AbstractThe cytochrome P450 monooxygenases (CYPs) are a class of heme‐thiolate enzymes that insert oxygen into unactivated C−H bonds. These enzymes can be converted into peroxygenases via protein engineering, which enables their activity to occur using hydrogen peroxide (H2O2) without the requirement for additional nicotinamide co‐factors or partner proteins. Here, we demonstrate that soaking crystals of an engineered P450 peroxygenase with H2O2 enables the enzymatic reaction to occur within the crystal. Crystals of the designed P450 peroxygenase, the T252E mutant of CYP199A4, in complex with 4‐methoxybenzoic acid were soaked with different concentrations of H2O2 for varying times to initiate the in crystallo O‐demethylation reaction. Crystal structures of T252E‐CYP199A4 showed a distinct loss of electron density that was consistent with the O‐demethylated metabolite, 4‐hydroxybenzoic acid. A new X‐ray crystal structure of this enzyme with the 4‐hydroxybenzoic acid product was obtained to enable comparison alongside the existing substrate‐bound structure. The visualisation of enzymatic catalysis in action is challenging in structural biology and the ability to initiate the reactions of P450 enzymes, in crystallo by simply soaking crystals with H2O2 will enable new structural biology methods and techniques to be applied to study their mechanism of action.