bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis, and Anti‐Glioma Activity Evaluation of Dehydroabietic Acid Derivatives
Authors: Liu Yuanhui , Qiu Yifeng , Li Ming , Liu Ying , Luo Yan , Chen Gong , Ye Lianbao 
Published: February 2025

AbstractDehydroabietic acid (DHAA) is a common natural product with a broad range of biological activities. In previous research, our group identified a range of dehydroabietic acid derivatives with strong anti‐glioma activity. In order to search for better anti‐glioma drugs candidates, new chalcone derivatives A1‐A10 and B1‐B10 were designed and synthesized in this study. The antiproliferative activity of these derivatives against U87 glioma cells was tested by CCK‐8 assay, in which A10 has the best IC50 value of 11.39 µM. Scratch and cloning studies further confirmed that A10 strongly inhibited the proliferation and colony‐forming activity of U87 cells. The antiproliferative activity of A10 on U87 cells showed some concentration dependence manner and the pKa values of A10 were within the desirable range of anti‐gliomas drugs. In addition, molecular docking revealed hydrogen bonding interaction was formed between A10 and the target protein. These results suggest that A10 may be a promising DHAA‐derived lead compound that deserves further strategic optimization in search of the anticancer candidates against glioma.
Structural and Kinetic Analysis of Photochromic Organic Salts Derived from 3,6‐Bis(bromomethyl)durene and Nicotinic Acid/Methyl Nicotinate
Authors: Tanaka Akihiro , Kusumoto Sotaro , Ide Takumi , Hamamoto Nobutsugu , Okamura Masaya , Hikichi Shiro , Kim Yang , Koide Yoshihiro , Hayami Shinya 
Published: February 2025

AbstractThe photochromic properties of organic bromide salts prepared from 3,6‐bis(bromomethyl)durene and nicotinic acid/methyl nicotinate were explored. UV exposure induced color changes, revealing distinct photoresponsive rates for each compound. Structural analysis, electron spin resonance (ESR), and DFT calculations elucidated the underlying mechanisms, highlighting the critical role of electron transfer and supramolecular interactions. This study provides structural insights to enhance the photochromic properties of non‐viologen compounds.
Tracing Service Request Processing in Cloud
Authors: Zhao Yinqin , Liu Chang , Yu Tao , Wang Long , Shi Xuanqing , Yang Yong , Li Ying , Wang Zhengang , Shangguan Dongdong 
Published: February 2025

ABSTRACTNowadays, more and more IT services are being hosted on cloud systems, which render cloud systems to grow into a huge complex with millions of physical servers, multi‐layer software stacks and the processing of cloud service requests across many servers and software layers. It is highly demanded for cloud service providers to have the capability of getting the knowledge on cloud service behaviour directly from the service execution instead of from people's expertise. This paper studies the problem of tracing cloud service's processing of requests across components in cloud environments and proposes cloud tracing mechanisms for this purpose. We also developed model‐based studies of our proposed mechanisms for analysing certain designs of the mechanisms. The implementation of the proposed cloud tracing is deployed onto the environments of OpenStack, Kubernetes and Hadoop, and the experiments on these environments demonstrate that our mechanisms effectively trace cloud service behaviour and generate a single complete request execution path, while without our mechanisms the cloud tracing either fails to work or results in thousands of path segments. Our mechanisms have a low performance overhead (2.3%) in the experiments.
Framing the Riviera: Touristic Performances and Photography in Contemporary Cascais, Portugal
Authors: Silva Eduardo , Ferro Lígia 
Published: February 2025

Abstract
As a touristic space, Cascais is an important site to pinpoint the development of tourism in Portugal—particularly, seaside
tourism. In turn, this social phenomenon has deeply shaped the imaginary of this town and its physical and human landscapes. And so, situated touristic performances were analysed considering how tourists are using and consuming sphotography as part of their embodied experiences in Cascais, thus seeking to shed light on the touristification process of
this town’s shoreline in a broader socio-historical context.
Contextualizing microplastic pollution in different river habitats through rapid habitat assessment in South Africa
Authors: Dahms Heinrich Theodor Jacob , Greenfield Richard 
Published: February 2025

Abstract
There has been a notable increase in research into microplastics in rivers over the last decade. However, no clear or concise standardized monitoring method exists for the sampling of microplastics in rivers. Many guidelines exist for the sampling and analysis of microplastics from rivers, but researchers continue to use methods and tools that may contaminate samples, such as plankton nets, or collect and filter bulk water samples with differing volumes and numbers of replicates. This can result in the same river system being shown to have notably varying levels of microplastics between sites. The aim of this study was to determine microplastic abundances in water and sediment, together with a critical evaluation of the sampling sites, to ascertain which environmental factors impacted microplastic distribution. This was achieved by applying the rapid habitat assessment method and simultaneously sampling microplastics. The results indicated that factors such as water velocity, physical obstructions to water flow and, most importantly, discharge, can change the context of a site with respect to its microplastic content, which can impact niche-specific organisms. The results were used to develop a new measurement unit, the microplastic discharge unit. The MDU provides a contextualized representation of the microplastics moving through a river, and can be used as an indicator of microplastic pollution at a site and its impact on biota. The results will be used further to produce a guide for the accurate sampling of microplastics in rivers.
Coupling between landward and seaward fringes of sandy beaches: algal deposits on the upper beach influence biogeochemistry and faunal assemblages in the swash zone
Authors: Lastra M , De Pablo L , López J , Soliño F , Schlacher TA 
Published: February 2025

Abstract
Energy subsidies from the sea typically underpin ocean-exposed sandy beach ecosystems. Strandings of detached macroalgae – ‘wrack’ – can be a spectacular form of such cross-ecosystem transfers of organic matter that sustain consumers in the recipient shore system; this has given rise to a model of wrack promoting the diversity and abundance of invertebrates, with scaling effects on upper trophic levels.
However, most wrack is often wave-cast to the upper beach, whereas a distinct part of the shore fauna is limited to the ocean fringe of beaches – the ‘swash zone’. This has the potential to create a spatial asymmetry between the location of subsidies (concentrated at the landwards fringe) and the location of some of the putative recipients distributed at the ocean fringe.
Here, we tested whether the fauna of the swash zone can benefit from wrack subsidies, by sampling fauna and algal deposits on a range of beaches in NW Spain. We also measured the potential functional link between algal wrack and nutrients released from wrack during decay.
Wrack decay increased nutrient concentrations, and it is the combination of wrack cover, nutrient levels, and sediment coarseness that jointly drove variation in the assemblage structure of the swash fauna among beaches. Similarly, the density of the swash fauna and species richness increased markedly at higher nutrient levels and wrack cover.
Filter feeders were an important compartment in the food web of the swash macrofauna; we hypothesize that wrack deposits in the upper beach enhance food availability for this trophic guild via increasing nutrients in the water column, stimulating primary production and providing particulate organic matter derived from algal decay. Besides, several polychaetes and peracarid species function as secondary consumers and detritus feeders that plausibly benefit, directly or indirectly, on the particulate organic matter that accumulates on the sediment surface or percolates into the interstitial environment.
These findings expand the ‘wrack enhancement’ model to include the promotion of consumers at the ocean edge of sandy shores; it also contains a cross-shore linkage via decomposition processes that favourably change the nutrient regime across all the beach face and thereby couple the swash zone with the upper strandline.
Discovery of the Ligament of Modiolus: Anatomical Insights and Clinical Relevance
Authors: Yi Kyu-Ho , Wan Jovian , Yoon Song-Eun , Cartier Hugues , Garson Sebastien , Jitaree Benrita , Kim Soo-Bin 
Published: February 2025

Abstract
The modiolus is a critical anatomical structure in facial expressions and oral competence, serving as a hub where multiple muscles converge. Our recent cadaveric study has identified a previously unreported structure, the ligament of modiolus, aligning with the line of ligament between the modiolus and its adjacent muscular and fascial attachments. This novel finding offers new perspectives on the anatomical organisation of the perioral region and its functional significance. Importantly, it has been identified as a false ligament rather than a true ligament, originating from the modiolus and extending to the dermal layer. The discovery has potential implications for aesthetic and reconstructive procedures involving the midface and oral commissures. Here, we present our findings and discuss their relevance to facial anatomy, surgical approaches, and clinical outcomes.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Multiple plan approach for a dynamic dial-a-ride problem
Authors: Ackermann Christian , Rieck Julia 
Published: February 2025

Abstract
In densely populated areas, ridepooling services are becoming more and more popular and can contribute to promote sustainable mobility concepts. In this paper, we study a dynamic dial-a-ride problem and propose a novel two-phase multiple plan approach. By maintaining multiple plans simultaneously over the course of the optimization procedure, we increase the likelihood and speed of a successful insertion for dynamically arising customer requests. Additionally, we present a new metric to replace the commonly used distance minimization as guidance within the optimization procedure. In order to examine the impact of certain instance characteristics on the quality of the solutions, we evaluate our design decisions on various instance sets. The results show that the proposed method consistently outperforms commonly used single plan approaches.
Medical management of cerebellar mutism syndrome at a quaternary children’s hospital
Authors: Xu Emily , Zhang Emily , Park Kristen , Ayub Mahaa , Zhao Chao , Huh Jimmy W. , King J. Michael , Paltin Iris , Shah Amish C. , Storm Phillip B. , Tucker Alexander , Madsen Peter J. , Lang Shih-Shan 
Published: February 2025

Abstract

Purpose
We aimed to evaluate the efficacy of selective serotonin reuptake inhibitors (SSRIs) in treating cerebellar mutism syndrome (CMS).

Methods
We retrospectively reviewed all pediatric patients who underwent a posterior fossa tumor resection between May 2007 to September 2022 at a single quaternary pediatric hospital. We evaluated clinical presentation and hospital course, including imaging findings, pathology, and surgical approaches. Propensity score matching was used to compare the symptom duration of patients who received SSRIs versus those who did not.

Results
A total of 292 patients met the criteria with 25% (n = 73) being diagnosed with CMS. Several factors were significantly associated with a CMS diagnosis, such as pre-operative hydrocephalus (p = 0.002), a vermis-splitting approach (p = 0.007), tumor in the fourth ventricle (p = 0.010), medulloblastoma diagnosis (p = 0.009), and postoperative complication (p < 0.001). Of the patients diagnosed with CMS, 32.9% (n = 24) received SSRI treatment, specifically fluoxetine (n = 18) and sertraline (n = 6). Overall, treatment did not decrease the duration of CMS symptoms or shorten the inpatient rehab course compared to matched controls. However, within the cohort of fluoxetine-treated patients, earlier initiation of medication was significantly correlated with a shorter duration of mutism (p = 0.007).

Conclusions
We report the largest cohort of CMS patients treated with SSRIs. The lack of overall clinical benefit when compared to untreated patients in our study may be due to the length of delay in starting an SSRI, since early initiation of fluoxetine correlated with shorter CMS symptoms. These results support the importance of early clinical detection of CMS and potentially treating CMS early in the patient’s postoperative course.
Moving toward a better understanding of renal lymphatics: challenges and opportunities
Authors: Zhong Jianyong , Liu Jing , Mutchler Ashley L. , Yang Haichun , Kirabo Annet , Shelton Elaine L. , Kon Valentina 
Published: February 2025

Abstract
The development of lymphatic-specific markers has enabled detailed visualization of the lymphatic vascular network that has greatly enhanced our ability to explore this often-overlooked system. Lymphatics remove fluid, solutes, macromolecules, and cells from the interstitium and return them to circulation. The kidneys have lymphatics. As in other organs, the kidney lymphatic vessels are highly sensitive to changes in the local microenvironment. The sensitivity to its milieu may be especially relevant in kidneys because they are central in regulating fluid homeostasis and clearance of metabolites delivered into and eliminated from the renal interstitial compartment. Numerous physiologic conditions and diseases modify the renal interstitial volume, pressure, and composition that can, in turn, influence the growth and function of the renal lymphatics. The impact of the renal microenvironment is further heightened by the fact that kidneys are encapsulated. This review considers the development, structure, and function of the renal lymphatic vessels and explores how factors within the kidney interstitial compartment modify their structure and functionality. Moreover, although currently there are no pharmaceutical agents that specifically target the lymphatic network, we highlight several medications currently used in children with kidney disease and hypertension that have significant but underappreciated effects on lymphatics.

Graphical abstract
Photovoltaic power one-day and multistep-hourly AI predictions using node-by-node evolved binomial tree structures to form L-transformed PDE modules
Authors: Zjavka Ladislav 
Published: February 2025

Abstract
Photovoltaic (PV) power is generated by two common types of solar components that are primarily affected by fluctuations and development in cloud structures as a result of uncertain and chaotic processes. Local PV forecasting is unavoidable in supply and load planning necessary in integration of smart systems into electrical grids. Intra- or day-ahead modelling of weather patterns based on Artificial Intelligence (AI) allows one to refine available 24 h. cloudiness forecast or predict PV production at a particular plant location during the day. AI usually gets an adequate prediction quality in shorter-level horizons, using the historical meteo- and PV record series as compared to Numerical Weather Prediction (NWP) systems. NWP models are produced every 6 h to simulate grid motion of local cloudiness, which is additionally delayed and usually scaled in a rough less operational applicability. Differential Neural Network (DNN) is based on a newly developed neurocomputing strategy that allows the representation of complex weather patterns analogous to NWP. DNN parses the n-variable linear Partial Differential Equation (PDE), which describes the ground-level patterns, into sub-PDE modules of a determined order at each node. Their derivatives are substituted by the Laplace transforms and solved using adapted inverse operations of Operation Calculus (OC). DNN fuses OC mathematics with neural computing in evolution 2-input node structures to form sum modules of selected PDEs added step-by-step to the expanded composite model. The AI multi- 1…9-h and one-stage 24-h models were evolved using spatio-temporal data in the preidentified daily learning sequences according to the applied input–output data delay to predict the Clear Sky Index (CSI). The prediction results of both statistical schemes were evaluated to assess the performance of the AI models. Intraday models obtain slightly better prediction accuracy in average errors compared to those applied in the second-day-ahead evening approach. However, the first-morning strategy application includes a much more complicated and time-consuming procedure, so in conclusion, the second one-mode series processing could be recommended. Model statistics are generally more successful than NWP data processing due to limitations, delays, and unavailability of free radiation or cloudiness forecasts in the systems. An all-day model enables the prediction of complete PVP periods in sequenced computing with acceptable operational quality in the late afternoon, which is inevitable in day-ahead management and load scheduling in smart grids based on PV energy.
Hardware-in-the-Loop testing for low-inertia grids
Authors: Goeke Felix , Hohmann Julian , Palaniappan Rajkumar , Rehtanz Christian 
Published: February 2025

Abstract
Extensive testing of various control algorithms using comprehensive testing frameworks enables us to assess their effectiveness in managing system dynamics and maintaining grid stability. In order to validate the algorithms in the real world, testing of the developed applications in an empirical laboratory environment is essential and the testing parameters in the laboratory have to closely resemble real-world conditions. The fundamental aspect of such testing is to monitor and analyze the dynamics and interaction between the various components in synchronous mode, thereby assessing the system’s ability to operate the grid without violations. The experimental test setup and script-based testing explained in this paper helps to develop innovative control algorithms, with a key focus on medium voltage and low voltage grids with low rotating masses. The test platform makes extended use of a Typhoon Real-Time Simulator (RTS). Firstly, it is used for the simulation of the distributed energy resources and the overlying distribution grid as well as the implementation of control algorithms. Secondly, the RTS acts as a control and SCADA system for the whole testing platform. While the physical components provide measurements in regular intervals, the control algorithms and the energy management system are implemented directly in the Typhoon platform. The data acquisition is performed either via programmable logic controllers for the nodal measurements or through faster measurements such as current transformers. This ensures that the developed algorithms are empirically tested and optimized in close to real-world conditions. The control algorithms provide the set points for the individual components, and the results show the advantages of script-based testing in HIL testing to ensure deterministic and reliable operation of innovative grid components.
A new technique: endoscopic transmass odontoidotomy
Authors: Bozkurt Ismail , Unsal Ulkun Unlu , Senturk Salim , Ozer Ali Fahir 
Published: February 2025

Abstract

Background & objectives
Basilar invagination (BI) represents a complex anomaly of the craniovertebral junction, characterized by the displacement of the odontoid process towards the foramen magnum. Current surgical interventions include anterior decompression and combined anterior-posterior decompression with posterior fusion. Traditional methods for odontoid resection encompass transoral, transnasal, and endonasal approaches. However, these techniques are fraught with significant risks. Furthermore, the restricted exposure provided by the endonasal corridor’s anatomical limitations hampers surgical manipulation, prompting spine surgeons to seek alternative techniques. This report details a case of BI managed through an endoscopic posterolateral odontoidotomy, showcasing an innovative surgical approach. We aim to describe our experience in partially removing the odontoid via posterolateral approach with a novel endoscopic technique, preventing the need for additional approach and related complications.

Methods
A 16-year-old male patient presented with complaints of imbalance and difficulty swallowing. Clinical examination revealed upper extremity muscle weakness, ataxic gait, and dysphagia. Upon the diagnosis of BI, a posterior occipito-cervical fusion was performed. However, six months postoperatively, the patient returned with exacerbated symptoms. During the subsequent surgical intervention, the odontoid body was resected using a posterolateral transmass endoscopic approach. Due to the patient’s neck and shoulder anatomy, cranial angulation of the endoscope was restricted, necessitating the retention of the odontoid tip.

Results
Post-operative CT revealed that the tip was closer to the base and a subarachnoid space was formed. Follow-up CT after a year showed a complete migration of the tip to the base of C2 with a clear decompression of the brainstem.

Conclusion
Our findings demonstrate that partial or total resection of the odontoid process via a posterolateral approach is feasible using endoscopic techniques. The endoscopic posterolateral transmass odontoidotomy should be considered a viable alternative method and route for patients necessitating partial or total odontoidectomy.
TGG1 and TGG2 mutations impair allyl isothiocyanate-mediated stomatal closure in Arabidopsis thaliana
Authors: Oumaima Kadri , Hossain Mohammad Shakhawat , Ye Wenxiu , Okuma Eiji , Issak Mohammad , Islam Mohammad Mahbub , Uraji Misugi , Nakamura Yoshimasa , Mori Izumi C. , Munemasa Shintaro , Murata Yoshiyuki 
Published: February 2025

Abstract
Myrosinase, referred to as thioglucoside glucohydrolase (TGG), plays a crucial role in plant physiology through catalyzing the hydrolysis of glucosinolates into bioactive isothiocyanates. In Arabidopsis thaliana, the myrosinases TGG1 and TGG2 are essential for abscisic acid- and methyl jasmonate-induced stomata closure. Allyl isothiocyanate (AITC), one of myrosinase products, triggers stomatal closure in A. thaliana. We investigated stomatal responses to AITC to clarify the role of TGG1 and TGG2 in Arabidopsis guard-cell signaling. Allyl isothiocyanate at 50 μM and 100 μM induced stomatal closure in the tgg1 and tgg2 single mutants but not in the tgg1 tgg2 double mutant. Furthermore, AITC at 50 μM induced the production of reactive oxygen species and nitric oxide, cytosolic alkalization, and oscillations in cytosolic free calcium concentration in guard cells of both wild-type and mutant plants. These findings suggest that TGG1 and TGG2 are involved in AITC signaling pathway through interaction with signal component(s) downstream of these signaling events, which is not accompanied by hydrolysis of glucosinolates because of the difference in subcellular localization between enzymes (myrosinases) and substrates (glucosinolates).