bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy:
Emphasis on Neuro-inflammation and Allodynia
Authors: Changkakoti Liza , Das Jitu Mani , Borah Rajiv , Rajabalaya Rajan , David Sheba Rani , Balaraman Ashok Kumar , Pramanik Subrata , Haldar Pallab Kanti , Bala Asis 
Published: November 2023

Abstract::
According to the World Health Organization (WHO), diabetes has been increasing
steadily over the past few decades. In developing countries, it is the cause of increased morbidity
and mortality. Diabetes and its complications are associated with education, occupation, and
income across all levels of socioeconomic status. Factors, such as hyperglycemia, social ignorance,
lack of proper health knowledge, and late access to medical care, can worsen diabetic complications.
Amongst the complications, neuropathic pain and inflammation are considered the most
common causes of morbidity for common populations. This review is focused on exploring protein
kinase C (PKC)-mediated TGF-β regulation in diabetic complications with particular emphasis on
allodynia. The role of PKC-triggered TGF-β in diabetic neuropathy is not well explored. This review
will provide a better understanding of the PKC-mediated TGF-β regulation in diabetic neuropathy
with several schematic illustrations. Neuroinflammation and associated hyperalgesia and
allodynia during microvascular complications in diabetes are scientifically illustrated in this review.
It is hoped that this review will facilitate biomedical scientists to better understand the etiology
and target drugs effectively to manage diabetes and diabetic neuropathy.
Help Comes from Unexpected Places: How a Tiny Fairy and a Tropical
Fish may help us Model Mucopolysaccharidoses
Authors: Carvalho Sofia , Moreira Luciana , Santos Juliana Inês , Gaspar Paulo , Gonçalves Mariana , Matos Liliana , David Hugo , Encarnação Marisa , Ribeiro Diogo , Duarte Ana Joana , Amaral Olga , Rocha Hugo , Diogo Luísa , Ferreira Sara , Santos Constança , Martins Esmeralda , Neuparth Teresa , Soares Joana , Ribeiro Marta , Ribeiro Pinho Brígida , Oliveira Nuno , Ascenção Oliveira Jorge Miguel , Prata Maria João , Santos Miguel , Alves Sandra , Coutinho Maria Francisca 
Published: November 2023

Introduction::
When it comes to disease modeling, countless models are available for
Lysosomal Storage Diseases (LSD). Historically, two major approaches are well-established: in
vitro assessments are performed in patient fibroblasts, while in vivo pre-clinical studies are performed
in mouse models. Still, both platforms have a series of drawbacks. Thus, we implemented
two alternative and innovative protocols

Methods::
The first one relies on a non-invasive approach using dental pulp stem cells from deciduous
teeth (SHEDs). SHEDs are multipotent neuronal precursors that can easily be collected.
The second uses a state-of-the-art gene editing technology (CRISPR/Cas9) to generate zebrafish
disease models.

Results::
Even though this is an ongoing project, we have already established and characterized
two MPS II and one MPS VI SHED cell models. These cells self-maintain through several passages
and can give rise to a variety of cells including neurons. Furthermore, all MPS-associated
sub-cellular phenotypes we have assessed so far are easily observable in these cells. Regarding
our zebrafish models, we have successfully knocked down both naglu and hgsnat and the first
results we got from the behavioral analysis are promising ones, as we can observe altered activity
and sleep patterns in the genetically modified fish. For this particular approach we chose MPS III
forms as our target disorders, since their neurological features (hyperactivity, seizures and motor
impairment) and lifespan decrease would be easily recognizable in zebrafish.

Conclusion::
Now that these methods are well-established in our lab, their potential is immense.
On one hand, the newly developed models will be of ultimate value to understand the mechanisms
underlying MPS sub-cellular pathology, which have to be further elucidated. On the other
hand, they will constitute an optimal platform for drug testing in house. Also noteworthy, our
models will be published as lab resources and made available for the whole LSD community.
Dihydropteridine Reductase Deficiency - A Rare and Potentially Treatable
Cause Mimicking Cerebral Palsy
Authors: Ribeiro Marta , Rebelo Mafalda , Pereira Andreia , Antunes Diana , Ferreira Ana Cristina , Jacinto Sandra 
Published: November 2023

Introduction:
Dihydropteridine reductase deficiency (DHPRD) is a rare genetic disorder of tetrahydrobiopterin (BH4) regeneration, a cofactor for several enzymes, including phenylalanine hydroxylase. Due to hyperphenylalaninemia (HPA), patients can be detected by the
newborn metabolic screening, when available. The most common symptoms of DHPRD may
mimic cerebral palsy: developmental/cognitive impairment, hypotonia, peripheral hypertonia,
dystonia, feeding difficulties, epilepsy, and microcephaly. The long-term neurodevelopmental
outcome is strongly influenced by the early initiation of effective treatment.

Case Report:
A 2-year-old boy, born in Guinea, was evaluated in our center with the diagnosis
of “cerebral palsy”. He was born after a prolonged labor, and had feeding difficulties and severe
developmental delay. Examination revealed microcephaly, axial hypotonia, and dyskinetic
movements without hypertension. No seizures or oculogyric crisis were reported. Brain MRI
showed slight brain atrophy and hyperintensity T2/FLAIR in basal ganglia. The diagnosis of
cerebral palsy was questioned, and further investigation was carried out. HPA raised the possibility of BH4 deficiency, supported by increased biopterin in urine, decreased neurotransmitters
in CSF, and low DHPR enzyme activity. A variant (128_130del (p.(Val43del)) in apparent homozygosity was later detected in the QPDR gene. At 4 years old, he started L-dopa/carbidopa,
oxitriptan, and a phenylalanine-restrictive diet with moderate clinical improvement.

Conclusion:
When the diagnosis of “cerebral palsy” is questionable, other etiologies should be
investigated, particularly disorders that have specific disease-modifying treatment. In our patient, the atypical constellation of neurological signs, brain MRI findings, and the nonexistence
of newborn metabolic screening in the country of origin supported additional investigation. The
presence of HPA-associated dystonia was crucial to the investigation and was later confirmed as
DHPRD. Unfortunately, at this stage, the reversibility of the neurological damage in response to
treatment is doubtful.
Bioconvection Flow in the Existence of MHD Casson Nanofluid with Viscous Dissipation and Chemical Reaction
Authors: Arun B. , Deivanayaki M. 
Published: November 2023

Objective:
Casson nanofluids are used to investigate the effects of Magneto hydrodynamics (MHD), viscous dissipation, temperature and concentration on convective heat transfer
flow through a stretching/shrinking vertical sheet.

Method:
The BVP4C method in MATLAB is used to obtain numerical solutions for solving the
governing Ordinary Differential Equations (ODEs) by converting them into the governing Partial
Differential Equations (PDEs) using similarity transformations. To examine the effects of pertinent variables, including the Magnetic parameter, the Brownian motion parameter, the Cassson
fluid parameter, the chemical reaction constant, the Prandtl number, the concentration to thermal
Buoyancy ratio, the microorganism to thermal Buoyancy ratio, the Lewis number, the bioconvection Peclet number, the bioconvection Lewis number, the local skin friction, the local Nusselt
number, the local Sherwood number and the local density number of the motile microorganisms.

Result:
Quantitative data are plotted according to the bioconvection flow, temperature, concentration and velocity profiles.

Conclusion:
It is observed that this study helps to compare the variations in the chemical reactions of the MHD Casson nanofluid by using graphs.
Assessing the Impact of E-learning through Usage and Preference of E-resources
Authors: Waghmode Manisha , Shukla Manisha , Sinha Deepti , Awati Jayashree S. , Kalse Anjali , Kharade Jyoti 
Published: November 2023

Aims:
Any electronic device that delivers a collection of data, whether it be text referring
to full text databases, electronic journals, photographs, other multimedia goods, or quantitative,
visualizations, or time-based, is referred to as an electronic resource. These could be transmitted
over the internet, tape, CD-ROM, tablets, smartphones, smart watches or another medium,
these are now the basis of e-learning. Online searching has made it possible to get patent information
more quickly, affordably, and conveniently than the traditional manual or CD-ROM based
searching method. The ability to create and distribute documents in electronic form is now made
possible by a number of established procedures and standards. So, in order to address the current
problems, librarians are utilizing new media, particularly electronic resources, in their collection
expansion makes the documentation of users better. As we can see, utilizing online resources is
important in the modern world for a multitude of purposes. Because of this, it's important to understand
the preferences, motives and usage of various ‘e- resources used by students who use
online learning’. The aim of the present research paper was to examine the impact of e-resources
using its usage and reading preferences. In this study, reasons such as time saving, more information,
and busy schedule at college are considered.

Methodology:
Primary data was gathered from 250 students from Mumbai and Navi Mumbai who
are using e-resources through the pre-structured questionnaire. The responses collected were recorded
using the SPSS software for data analysis. In order to examine the link between causes,
preferences, and the use of ‘e-resources’, a theoretical construct was developed grounded on a few
assumptions. Statistical techniques like the chi-square test were used and data analysis was done
using SPSS version 20 to examine the proposed construct. When doing the data analysis, the demographic
profile, objectives, and hypothesis were all taken into consideration.

Result:
The average for each component that is time saving, more informative, and busy schedule
at college was computed and was determined as 0.004, 0.004, and 0.000, correspondingly, for
time saving, more informative content, and busy college schedule. As all of these values for all of
the preferences under consideration are less than 0.05, it is clear that there is a connection between
the usage of electronic resources and their underlying reasons and preferences.

Conclusion:
Hence, there is a substantial correlation between the reasons for using electronic resources
and the different reading preferences, as well as between the two. Only three reasons
namely time saving, more informative, and busy schedule at college are considered during this
study. Data collection is done from Mumbai and Navi Mumbai region only.
La teoría homeostática presente en la medición de la satisfacción con la vida en México a través de un sistema de inferencia difuso
Authors: Ortigosa Hernández Mauricio 
Published: November 2023

<p><span>Se ha visto que las medidas económicas objetivas como el PIB no reflejan fielmente el bienestar de la sociedad. Por ello, se han utilizado otras mediciones subjetivas como la satisfacción con la vida, siendo éste el indicador principal del bienestar subjetivo que se examina por medio de la autoevaluación que hace la propia persona sobre su vida. Lo anterior ha dado lugar a la teoría homeostática. Esta teoría indica que la persona evalúa su nivel de satisfacción con su vida de forma positiva y en el sentido más general. La respuesta que la persona manifiesta, refleja el nivel en el que opera el sistema homeostático como mecanismo de autorregulación para adaptarse ante variaciones del exterior. El objetivo de la presente investigación es mostrar la presencia de dicho sistema al medir la satisfacción con la vida a través de un método de inferencia difuso. Para lograr tal medición, se utiliza una parte de los datos publicados referentes al bienestar subjetivo que genera la encuesta BIARE Básico, gestionada por el Instituto Nacional de Estadística y Geografía (INEGI). Los valores numéricos de este proceso muestran un comportamiento estable y positivo, ilustrando con esto el principio de la homeostasis que rige dicha teoría</span></p>
LEGAL SOCIOLOGY OF LAND CONFLICT VS ORANG RIMBA’S LAND CONFLICT IN JAMBI PROVINCE
Authors: Ulma Riri Oktari , Rahmi Elita , Fitria Fitria , Pratiwi Cholillah Suci 
Published: November 2023

The sociology of Orang Rimba Law, which portrays the issue of land conflict versus land conflict, is a crucial legal issue, even though so far, the Orang Rimba (Suku Anak Dalam) has been part of a beneficial symbiosis between Natural Resources and Human Resources (HR), because between the factors of mutual care between humans and nature, but in legal reality, land and land tenure in Indonesia, The existence of the Orang Rimba institution as the original entity of the Malay tribe is a problem, because its living entity has been displaced by the laws of outsiders, namely the state and government, especially since the rolling of the issue of forest utilization through Forest Tenure Rights (HPH) and the use of forest products through legal entities whose ownership is by forest outsiders, plus natural disasters (forest fires) outsiders as people whom people have long feared as eating creatures human. The purpose of the study is to know the law in reality, especially society. Conclusion The Orang Rimba, as an indigenous entity in Jambi Province, must be brought to the attention of the local government. The right to life and other social rights, namely distinctive economic and cultural rights, must be fostered continuously so that their customary rights are protected from land grabs under the guise of plantations and forestry based on state approval of forests and non-forests and ignore the history of the Orang Rimba struggle which always maintains the forest ecosystem and its distinctive land and culture such as ritual rituals between man and nature to dispel nature's various kinds of anger against humans in the form of disasters, wrath, and even climate change, cultural mantras and dialects were developed by them, but have not been seen by Indonesian law as genuine and distinctive legal institutions.
Medical Students’ Knowledge and Perceptions of Mpox in a High Incidence Region: Implications for Clinical Preparedness
Authors: Nusynowitz Jake , Jamneshan Lily , Garba Nana Aisha , Samuels Marquita , Bhoite Prasad , Stumbar Sarah E. 
Published: November 2023

Introduction: In August 2022, mpox (formerly “monkeypox”) was declared a public health emergency in the United States, yet there has been little published on medical providers’ knowledge or perceptions of the disease. With one of the highest incidence rates in the United States being in South Florida, our Miami-based medical school aimed to assess students' perceived levels of knowledge and attitudes regarding mpox.
Methods: An optional, anonymous survey consisting of multiple choice and Likert-type questions was emailed to all medical students. The first survey was sent out September 1, 2022, after which students received reminders on October 3, 8, and 31, 2022. We analyzed respondents’ perceived knowledge and risk of contracting mpox by comparing responses between heterosexual and LGBTQ+ groups and preclinical and clinical groups. We used Mann-Whitney U or Kruskal Wallis tests for inferential statistical analysis.
Results: Of 480 medical students, 168 (35.0%) responded to the survey. Most respondents (88.1%) were not concerned about mpox; 95.2% perceived their personal risk to be moderate or low. LGBTQ+ students were significantly more likely than others to report feeling at risk from mpox. The majority (72.0%) of respondents reported poor perceived knowledge of mpox. There was no significant difference between preclinical and clinical students' reported level of perceived knowledge (P=.0621); 76.2% of respondents were not confident in their ability to recognize mpox symptoms. LGBTQ+ students were significantly more confident in identifying symptoms than others (P=.0201).
Conclusion: Medical students feel they lack critical knowledge of mpox and report being unprepared to recognize disease symptoms. The higher level of perceived risk and knowledge among LGBTQ+ students may stem from biases perpetuated by public messaging regarding mpox. These findings highlight the need for integrating education on emerging epidemics into undergraduate medical education to enable students to safely provide high-quality patient care.
Identifying Public Value of Zakat Management Organizations: A Review of Muzaki's Perception
Authors: Ansoriyah Faizatul , Kushandajani  , Hartuti Purnaweni  , Retno Sunu Astuti  , Son Haji  
Published: November 2023

Zakat gain in Indonesia as the largest Muslim country in the world has not been compatible to its potential. The issuance of Law Number 23 of 2011 about Zakat management is the manifestation of Government’s attention to an attempt of maximizing zakat management. This study aims to analyze the public value of Zakat Managing Organization (Indonesian: Organisasi Pengelola Zakat or OPZ) viewed from muzaki’s perspective. The research method used was mix methods by analyzing the vision and mission of zakat managing organization and interviewing the zakat institution organizer, and using face-to-face questionnaire distributed to muzakis. The result of the research shows that there are some values identified for zakat managing organization: trustability (amanah), accountability, transparency, and synergy. Trust or trustability is intrinsic value, while accountability, transparency, and synergy are instrumental values. The identified indicator of both intrinsic and instrumental values can be the basis for OPZ to consider muzakis’ need to maximize zakat management.
A Multicenter Prospective Evaluation of the Benefits of Two Advanced Hybrid Closed-Loop Systems in Glucose Control and Patient-Reported Outcomes in a Real-world Setting
Authors: Beato-Víbora Pilar Isabel , Chico Ana , Moreno-Fernandez Jesus , Bellido-Castañeda Virginia , Nattero-Chávez Lia , Picón-César María José , Martínez-Brocca María Asunción , Giménez-Álvarez Marga , Aguilera-Hurtado Eva , Climent-Biescas Elisenda , Azriel-Mir Sharona , Rebollo-Román Ángel , Yoldi-Vergara Carmen , Pazos-Couselo Marcos , Alonso-Carril Nuria , Quirós Carmen 
Published: November 2023

OBJECTIVE
Advanced hybrid closed-loop systems (AHCL) have been shown to improve glycemic control and patient-reported outcomes in type 1 diabetes. The aim was to analyze the outcomes of two commercially available AHCL in real life.

RESEARCH DESIGN AND METHODS
A prospective study was performed, including adolescents and adults with type 1 diabetes, AHCL naïve, from 14 centers, who initiated the use of MM780G with SmartGuard or Tandem t:slimX2 with Control-IQ. Baseline and 3-month evaluations were performed, assessing HbA1c, time in different glycemic ranges, and patient-reported outcomes. The primary outcome was the between-group time in range 70–180 mg/dL difference from beginning to end of follow-up.

RESULTS
One hundred fifty participants were included, with 75 initiating each system (age: 39.9 ± 11.4 years [16–72]; 64% female; diabetes duration: 21.6 ± 11.9 years). Time in range increased from 61.53 ± 14.01% to 76.17 ± 9.48% (P &lt; 0.001), with no between-group differences (P = 0.591). HbA1c decreased by 0.56% (95% CI 0.44%, 0.68%) (6 mmol/mol, 95% CI 5, 7) (P &lt; 0.001), from 7.43 ± 1.07% to 6.88 ± 0.60% (58 ± 12 to 52 ± 7 mmol/mol) in the MM780G group, and from 7.14 ± 0.70% to 6.56 ± 0.53% (55 ± 8 to 48 ± 6 mmol/mol) in the Control-IQ group (both P &lt; 0.001 to baseline, P = 0.819 between groups). No superiority of one AHCL over the other regarding fear of hypoglycemia or quality of life was found. Improvement in diabetes-related distress was higher in Control-IQ users (P = 0.012). Sleep quality was improved (PSQI: from 6.94 ± 4.06 to 6.06 ± 4.05, P = 0.004), without differences between systems. Experience with AHCL, evaluated by the INSPIRE measures, exceeded the expectations.

CONCLUSIONS
The two AHCL provide significant improvement in glucose control and satisfaction, with no superiority of one AHCL over the other.
Establishment of In Vitro Cultures and Genetic Fidelity Analysis in Valeriana jatamansi -a High Value Endangered Medicinal Herb
Authors: Sharma Sneh , Sharma Sakshi , Sharma Vivek 
Published: November 2023

The present study was conducted in the Department of Biotechnology, College of Horticulture and Forestry, Neri, Hamirpur, Himachal Pradesh, India during 2018–2020 for 18 months to develop an efficient, rapid and reproducible protocol for in vitro establishment along with analysing antioxidant activity. In the present study, surface sterilization protocol was standardized using Sodium hypochlorite and mercuric chloride as sterilant. Maximum direct shoot induction frequency from nodal explant was achieved on Murashige and Skoog medium enriched with BAP (5.0 mg l-l), TDZ (3.0 mg l-l) and NAA (1.0 mg l-l) for 18 days. Microshoots inoculated on MS media supplemented with 4.0 mg l-l BAP, 2.0 mg l-l TDZ, 1.0 mg l-l NAA and 0.5 mg l-l GA3) showed maximum frequency of shoot multiplication with average shoot length (4.36±0.08 cm) and average shoot number (14.00±0.57). A 75.00±1.15% rooting with significantly high mean root number (8.00±0.57) and root length was achieved in full strength MS medium, supplemented with same concentration i.e. 4.0 mg l-l BAP, 2.0 mg l-l TDZ, 1.0 mg l-l NAA and 0.5 mg l-l GA3) combination. Maximum plantlets survive after 1 year of acclimatization. RAPD and ISSR markers were used to confirmed genetic stability of in vitro raised plants by showing 100% monomorphism. High multiplication rate associated with genetic stability ensure the efficacy of the present in vitro clonal propagation protocol of this important medicinal plant.
Effect of Adding Coconut Water (Cocus viridis) on Liquid Semen Quality of Kacang Goats (Capra aegagrus hircus) Stored at 4-5° C
Authors: Rokana Efi , Sayoga Yusuf Aris , Lisnanti Ertika Fitri , Mukmin Amiril 
Published: November 2023

The best semen quality is necessary for successful Artificial Insemination. Increasing population of Kacang goat, which is a native Indonesian goat breed can reach with the application of AI technology. It can support the suffice of national meat demand. The purpose of this study was to determine the effect of adding coconut water (CW) in the Skim Yolk Diluent (SYD) and storage time at a cold temperature of 4-5 C on the quality of liquid semen of Kacang goat. The research material was four Kacang goats aged 1 - 1.5 years, SYD, and coconut water. The research method was an experiment with a factorial randomized block design (RBD) consisting of two factors. The first factor is the addition of coconut water in SYD (D), namely D0 = 100% SYD + 0% CW; D1= 30% SYD + 70% CW; D2= 20% SYD + 80% CW; D3= 10% SYD + 90% CW. The second factor is the storage time of liquid cement at a temperature of 4-5°C (H), namely H0 = 0 days; H1= 1 day; H2 = 2 days, and H3 = 3 days. The treatment was repeated 10 times. Data were analyzed by Anova and further test using Duncan's multiple distance test. The results showed that the combination treatment showed a significantly different interaction effect (P<0.05) on the percentage of motility and abnormalities and the highly significant different interaction effect (P<0.01) on the percentage of spermatozoa viability. The best mean of motility, viability and abnormality was found in the D3H0 treatment. The conclusion is that the addition of coconut water in SYD can be done up to 90% with the time storage at 4-5ºC cold for 3 days because it is still able to maintain the quality of the Kacang goat liquid semen with a motility percentage more than 40%.