bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОКРЕМІ АСПЕКТИ РОЗВИТКУ НОВИХ МЕТОДИК У КРИМІНАЛІСТИЦІ
Authors: Дідківська Г. В. , Педан В. І. 
Published: December 2023

У цій статті зазначено, що з огляду на те, що криміналістика є окремою галуззю знань, а її власні методи щодо загальної класифікації методів пізнання можуть визначатися як окремонаукові. Водночас звертається увага, що у класифікації методів криміналістики їх бажано визначати як спеціальні, підкреслюючи тим самим своєрідність цих пізнавальних засобів щодо сфери криміналістичних досліджень. Серед загальнонаукових методів, які, безумовно, пронизують усі напрями криміналістичних досліджень, особливо виокремлені ті, що становлять основу для формування нових сучасних пізнавальних підходів. Ідеться передусім про формалізацію, системний, структурно-функціональний та імовірно-статистичний методи.
Акцентується увага на тому, що криміналістичні методи створені та обґрунтовані теорією криміналістики або запозичені та перетворені нею спеціально для дослідження криміналістичних об’єктів. До них належать різноманітні судово-фотографічні, трасологічні, судово-балістичні та інші методи. Наприклад, у галузі судової фотографії розроблені методи сигналетичної (впізнавальної), вимірювальної, панорамної, стереоскопічної, мікроскопічної, крупномасштабної та інших видів фотозйомки, методи фотографічного підсилювання кольорових контрастів, методи виявлення текстів, що неможливо прочитати, тощо.
Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents
Authors: Yang Yaochen , Yang Yuanyuan , Hou Zhipeng , Wang Tingting , Wu Peng , Shen Lufan , Li Peng , Zhang Kai , Yang Liqun , Sun Siyu 
Published: December 2023

Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions.
Recovery of uranium from phosphate ore in the Sheikh Habil-Iran mine: part I— multivariable optimization of leaching process using the response surface method
Authors: Abdeshahi A. , Outokesh M. , Nejad D. Ghoddocy , Zare M. Habibi , Sadeghi M. H. 
Published: December 2023

In this research, the recovery of uranium from the phosphate ore of the Sheikh Habil-Iran mine using flotation/calcination-leaching processes has been investigated. A 75–150 μm phosphate ore particle size, sodium oleate as a collector with a concentration of 2,000 g/ton of rock, pH = 10, and 5 min flotation time were obtained as the optimum parameters of flotation using the reverse method, leading to phosphate ore with a grade of 180 ppm UO2, 36.1% P₂O₅, 7.22% SiO2, and CaO/P₂O₅ = 1.23. The optimum calcination parameters were selected as 100 μm phosphate ore particles size at D80, 900°C temperature, and 2 h heating time, which resulted in phosphate ore with a grade of 173 ppm UO2 and 31.9% P₂O₅. An L/S (liquid to solid ratio) = 5, 3 M sulfuric acid concentration, 80°C temperature, and 5 h leaching time were obtained as the optimum leaching parameters using the response surface methodological approach. The efficiency of uranium recovery from phosphate ore pre-treated by flotation and calcination methods was 84.2% and 75.2%, respectively. The results indicated that flotation has superiority over calcination as a pre-treatment method of phosphate ore in the Sheikh Habil-Iran mine.
Development and testing of a transcatheter heart valve with reduced calcification potential
Authors: Weich Hellmuth , Botes Lezelle , Doubell Anton , Jordaan Johan , Lewies Angelique , Marimuthu Prennie , van den Heever Johannes , Smit Francis 
Published: December 2023

IntroductionPatients from developing countries who require heart valve surgery are younger and have less access to open heart surgery than those from developed countries. Transcatheter heart valves (THVs) may be an alternative but are currently unsuitable for young patients because of their inadequate durability. We developed and tested a THV utilizing two new types of decellularized bovine pericardial leaflets in an ovine model.MethodsThe two decellularized tissues [one with a very low dose (0.05%) of monomeric glutaraldehyde (GA) fixation and detoxification (DF) and the other without glutaraldehyde (DE)] were compared to an industry standard [Glycar—fixed with the standard dose (0.625%) of glutaraldehyde]. THVs were manufactured with the three tissue types and implanted in the pulmonary position of nine juvenile sheep for 180 days. Baseline and post-explantation evaluations were performed to determine the hemodynamic performance of the valves and their dynamic strength, structure, biological interaction, and calcification.ResultsHeart failure occurred in one animal due to incompetence of its Glycar valve, and the animal was euthanized at 158 days. The gradients over the Glycar valves were higher at the explant than at the implant, but the DE and DF valves maintained normal hemodynamic performance throughout the study. The DF and DE tissues performed well during the mechanical testing of explanted leaflets. Glycar tissue developed thick pannus and calcification. Compared to Glycar, the DF tissue exhibited reduced pannus overgrowth and calcification and the DE tissue exhibited no pannus formation and calcification. All tissues were endothelialized adequately. There was a striking absence of host ingrowth in the DE tissue leaflets, yet these leaflets maintained integrity and mechanical function.ConclusionIn the juvenile sheep THV model, Glycar tissue developed significant pannus, calcification, and hemodynamic deterioration. Using a very low dose of monomeric GA to fix the decellularized bovine pericardium yielded less pannus formation, less calcification, and better hemodynamic function. We postulate that the limited pannus formation in the DF group results from GA. Bovine pericardium decellularized with our proprietary method resulted in inert tissue, which is a unique finding. These results justify further development and evaluation of the two decellularized tissue types in THVs for use in younger patients.
Listen to the patients! Identifying CML patients' needs analyzing patient-generated content with AI-driven methodologies
Authors: Scholz Stefanie , Berns Isabell , Winkler Christian 
Published: December 2023

BackgroundVarious patient support programs exist to provide successful therapy options for patients. Pharmaceutical companies are increasingly recognizing the importance of actively supporting patients in their long-term treatment. In order to effectively assist patients, it is crucial to understand their current needs by taking a look at the patients' opinions.ObjectiveThis study focuses specifically on chronic myeloid leukemia (CML) and aims to determine if the current patient engagement offerings from pharmaceutical companies adequately address the needs of CML patients. To achieve this, the study uses content generated by CML patients to assess the patient engagement strategies of selected pharmaceutical companies, explore the relevance of medication, their products, and services, and analyze key concerns from the perspective of the patients.MethodsTo address the research questions, various methodologies were employed. Initially, desk research was conducted to identify relevant pharmaceutical companies and internet forums related to CML. Subsequently, content generated by patients was acquired and AI-driven techniques such as topic modeling and topic evolution analyses were used to examine this user-generated content (UGC) within the identified public forums. This involved analyzing topic models and tracking topic changes over time.ResultsThe desk research revealed that pharmaceutical companies primarily offer information about the disease and available treatment options. The UGC analysis confirmed the significant role played by the industry in supporting CML patients. Key areas of interest for patients include the disease itself, potential treatment methods and associated side effects, dosage of active substances, and the possibility of switching therapies due to treatment failure or resistance. Stem cell transplantation was also discussed.ConclusionsOverall, the pharmaceutical industry adequately addresses the needs of CML patients. However, there is room for improvement in educating patients about treatment options, drugs, and their side effects. Psychological support should not be neglected. Since CML patients frequently engage with clinical trial outcomes, there is potential for increased patient involvement in such trials. Further research in this area is recommended.
Development of a core outcome set for cardiovascular diabetology: a methodological framework
Authors: Jiao Jiao , Chen Lingmin , Peng Yong , Jia Qingyi , He Ying , Zhang Yonggang , Li Nian 
Published: December 2023

BackgroundCardiovascular diabetology is an emergent field focusing on all aspects of diabetes/cardiovascular interrelationship and metabolic syndrome. High-quality evidence needs to be provided to determine the efficacy and safety of interventions in cardiovascular diabetology. The heterogeneity of outcomes among trials limits the comparison of results, and some outcomes are not always meaningful to end-users. The cardiovascular diabetology core outcome set (COS) study aims to develop a COS of interventions for cardiovascular diabetology. In this paper, we introduce the methodological framework for developing the COS.MethodsThe COS development will include the following steps: (a) establish the COS groups of stakeholders, including international steering committee, Delphi survey group, and consensus meeting group; (b) systematic reviews of outcomes used in trials of cardiovascular diabetology; (c) semistructured interview of stakeholders for outcomes of cardiovascular diabetology; (d) generate a list of candidate outcomes and determine the original outcome pool; (e) Delphi survey with stakeholders of cardiovascular diabetology to select potential core outcomes; and (f) review and endorse the cardiovascular diabetology COS by expert consensus meeting.ConclusionsThis current study reports the methodological framework to develop a COS in cardiovascular diabetology and will provide evidence for the future development of COS in cardiovascular diabetology.
Investigation into the dynamic change pattern of the stress field during integral fracturing in deep reservoirs
Authors: Lv Bei , Lv Zhenhu , Luo Yao , Chen Jiameng , Zhang Li , Wang Bo 
Published: December 2023

Deep reservoirs have high temperature, high pressure, and high stress. The development of such resources is high cost. Integral fracturing applies one-time well displacement, batch drilling, and batch fracturing. Multiple wells are stimulated with zipper fracturing. It can avoid the interference of the well drilling and fracturing. In this way, the spatial stresses can be utilized to generate the complex fracture network. The dynamic change pattern of the stress field is of great value for the design of integral fracturing. Based on the displacement discontinuity method (DDM) and the fracture mechanics criteria, a whole fracture propagation program is developed to calculate the spatial stress distribution and the whole fracture geometry. The reliability of the program is verified against the classical analytical solutions. Based on the program, this work systematically investigates the effects of the fracture length, the fracturing sequence, the fracture distribution mode, and the injection pressure on the stress field. The main conclusions are as follows: 1) When the fracture half-length is 150 m and the well spacing is 300 m, the staggered fracture distribution mode can ensure uniform fracture propagation and realize the active utilization of inter-well stress field; 2) Compared with the relative fracture distribution mode, the staggered fracture distribution mode is less susceptible to the stress field induced by the adjacent hydraulic fractures, hydraulic fractures tend to propagate along the direction of the maximum horizontal principal stress; 3) The stress field is highly influenced by the in-fracture fluid pressure. The stress interference is stronger with a greater fluid injection pressure and a higher fracture deflection angle will be obtained. It can enhance the fracture propagation resistance and increase the stress value. This work discovers the stress change pattern and lays out a solid foundation for the optimization of the integral fracturing.
Comprehensive analysis of influencing factors and mechanism of nano emulsion spontaneous imbibition oil displacement in tight sandstone reservoir
Authors: Li Zhuang 
Published: December 2023

Tight sandstone reservoir has the characteristics of low porosity, low permeability and strong reservoir heterogeneity, which leads to a rapid decline in single well production after hydraulic fracturing. Adding nano emulsion to fracturing fluid can not only realize the dual function of fracturing and imbibition oil displacement, but also effectively prolong the stable production time of oil wells. In order to improve the understanding of the interaction between nano emulsion and reservoir, this paper based on the basic physical property test and analysis of nano emulsion, macroscopic and microscopic spontaneous imbibition oil displacement experiments, the mechanism of imbibition displacement of nano emulsion in tight sandstone reservoirs and the influence of related factors is clarified. The results show that: ①The particle size of the three types of nano emulsions ranges from 11 to 16 nm, and they can enter the nanopore throats deep in the reservoir, and can achieve good injectivity in tight reservoirs. The anionic AES nano emulsion is superior to cationic ADT and nonionic AEO-9 nano emulsion in terms of injectability, oil-water interfacial tension and wetting modification effect in tight sandstone cores, and the optimal concentration is 0.30 wt%. ②Spontaneous imbibition oil displacement experiments show that the nano emulsion concentration is not the higher the better. Since the nano emulsion adsorption on the solid surface reaches a dynamic equilibrium, the excessive nano emulsion cannot further change the wettability of the solid surface, and the lower oil-water interfacial tension has the opposite effect on the imbibition displacement. ③The migration and gathering of emulsified oil droplets in solution mainly included five processes: Saturated oil core/Nano-surfactant fluid emulsion reaction, Aqueous/Emulsified oil droplets, Emulsified oil droplet gathering phase, Demulsifying and emulsifying oil droplets, Oil phase after demulsification. The generation of remaining oil in porous media is due to the non-uniform wetting modification in different regions. This study further improves the understanding of the mechanism of spontaneous imbibition of nano emulsion in tight sandstone reservoirs.
Real-world observational study on the long-term effect of L-glutamine treatment on renal parameters of adult and pediatric patients with sickle cell disease
Authors: Elenga Narcisse , Yassin Mohamed A. 
Published: December 2023

BackgroundSickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in both pediatric and adult patients with serious consequences leading to increased risk of mortality. In this observational real-world study, we are reporting the long-term (120 weeks) renal function in 10 patients treated with L-glutamine.MethodsTen patients (4 pediatric and 6 adults), with confirmed diagnoses of SCD (HbSS genotype), were enrolled, these included four patients from Qatar with Arab Indian haplotype and six patients from French Guiana with African haplotype. All patients were treated with L-glutamine oral powder (~0.3 g/kg body weight, Endari®) twice daily for 120 weeks. Clinical events and laboratory parameters (renal function, hemoglobin, reticulocytes, and lactate dehydrogenase [LDH]) were measured at baseline, 48, and 120 weeks.ResultsThe study showed that with L-glutamine treatment there were improvements in renal and hematological parameters with no vaso-occlusive crisis at both 48-and 120-week follow-up time points in all 10 patients. Improvements were seen in the albumin creatinine ratio (ACR) from baseline to 48 weeks (mean [Standard deviation SD] ACR: −4.19 [9.81] mg/g) and 120 weeks (mean [SD] ACR: −12.31 [21.09] mg/g). Mean (SD) increase in hemoglobin concentrations from baseline to 48 weeks and 120 weeks was 0.72 (1) g/dL and 1.41 (0.79) g/dL, respectively. Mean (SD) reticulocyte counts and LDH levels decreased from baseline to 48 weeks (mean [SD] change from baseline to 48 weeks, reticulocyte counts: −40.30 [101.58] × 109 cells/L; LDH levels: −259 [154.93] U/L) and 120 weeks (mean [SD] change from baseline to 120 weeks, reticulocyte counts: −58.30 [128.38] × 109 cells/L; LDH levels: −344.80 [274.63] U/L).ConclusionThis is one of the first studies that assessed the long-term renal outcomes in SCD using L-glutamine. L-glutamine improved the renal function in patients with SCD along with improvements in clinical outcomes and hemolysis, from 48 weeks and sustained through 120 weeks of treatment.
Distinguishing EGFR mutant subtypes in stage IA non-small cell lung cancer using the presence status of ground glass opacity and final histologic classification: a systematic review and meta-analysis
Authors: Qiu Jianhao , Ma Zheng , Li Rongyang , Qu Chenghao , Wang Kun , Liu Binyan , Tian Yu , Tian Hui 
Published: December 2023

BackgroundThe progression of early stage non-small cell lung cancer (NSCLC) is closely related to epidermal growth factor receptor (EGFR) mutation status. The purpose of this study was to systematically investigate the relationship between EGFR mutation status and demographic, imaging, and ultimately pathologic features in patients with NSCLC.MethodsA complete literature search was conducted using the PubMed, Web of Science, EMBASE, and Cochrane Library databases to discover articles published by May 15, 2023 that were eligible. The relationship between EGFR mutation status and specific demographic, imaging, and ultimately pathologic features in patients with NSCLC was evaluated using pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The standardized mean difference (SMD) with 95% CIs was the appropriate statistic to summarize standard deviations (SDs) means for continuous variables.ResultsA total of 9 studies with 1789 patients were included in this analysis. The final findings suggested that patients with a greater age, female gender, and non-smoking status would have a relatively higher incidence of EGFR mutations. Additionally, the risk of EGFR mutations increased with larger tumor diameter, tumor imaging presentation of mixed ground glass opacity (mGGO), and tumor pathological findings of minimally invasive adenocarcinoma (MIA) or invasive adenocarcinoma (IAC). Significantly, malignancies presenting as MIA are more likely to contain L858R point mutations (OR = 1.80; 95% CI: 1.04–3.13; p = 0.04) rather than exon 19 deletions (OR = 1.81; 95% CI: 0.95–3.44; p = 0.07).ConclusionThis meta-analysis showed that imaging parameters and histological classifications of pulmonary nodules may be able to predict stage IA NSCLC genetic changes.
The gut microbiome and metabolites are altered and interrelated in patients with functional constipation
Authors: Li Yan-qiu , Yan Xiang-yun , Xiao Xian-jun , Ma Pei-tao , Wang Si-qi , Liu Hui-lin , Zhang Wei , Chen Min , Yao Jun-peng , Li Ying 
Published: December 2023

IntroductionGut microbiota and metabolites have been identified to contribute to the pathogenesis of functional constipation (FC); however, the underlying mechanism(s) have not been elucidated, and the relationship between the gut microbiota and metabolites in FC has received limited attention in the literature.Methods16S rDNA sequencing and non-targeted metabolomic detection based on liquid chromatography-mass spectrometry (LC–MS/MS) technologies were combined to analyze the altered gut microbiome and metabolic profile of fecal samples from FC patients and healthy individuals (healthy control; HC).ResultsThe richness and diversity of gut microbiota significantly (p &lt; 0.01) increased in FC patients. Compared to the HC group, 18 genera, including Intestinibacter, Klebsiella, and Akkermansia, exhibited statistically significant changes (p &lt; 0.05). Metabolic analysis showed that metabolic profiles were also markedly altered with 79 metabolites, such as (-)-caryophyllene oxide, chenodeoxycholic acid, and biliverdin, indicating significant inter-group differences (p &lt; 0.05). Besides, the primary bile acid biosynthesis, as well as the metabolic profile of porphyrin and chlorophyll, were the most dominant enriched pathways (FDR &lt; 0.01), in which chenodeoxycholic acid and biliverdin were significantly enriched, respectively. Correlation analysis demonstrated a strong relationship between 10 genera and 19 metabolites (r &gt; 0.6, FDR &lt; 0.05), and notably, Intestinibacter showed a negative correlation with biliverdin (FDR &lt; 0.001), which highlighted the interplay of the gut microbiota and metabolites in the pathogenesis of FC.ConclusionOur research describes the characteristics of the gut microbiota and metabolic profiles and the correlation between the gut microbiota and metabolites in FC patients. This may contribute to the understanding of the underlying mechanisms involved in FC pathogenesis and may provide novel insights into therapeutic interventions.