bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting sepsis-related mortality and ICU admissions from telephone triage information of patients presenting to out-of-hours GP cooperatives with acute infections: A cohort study of linked routine care databases
Authors: Loots Feike J. , Smits Marleen , Jenniskens Kevin , Leeuwenberg Artuur M. , Giesen Paul H. J. , Ramerman Lotte , Verheij Robert , van Zanten Arthur R. H. , Venekamp Roderick P. 
Published: December 2023

Background
General practitioners (GPs) often assess patients with acute infections. It is challenging for GPs to recognize patients needing immediate hospital referral for sepsis while avoiding unnecessary referrals. This study aimed to predict adverse sepsis-related outcomes from telephone triage information of patients presenting to out-of-hours GP cooperatives.

Methods
A retrospective cohort study using linked routine care databases from out-of-hours GP cooperatives, general practices, hospitals and mortality registration. We included adult patients with complaints possibly related to an acute infection, who were assessed (clinic consultation or home visit) by a GP from a GP cooperative between 2017–2019. We used telephone triage information to derive a risk prediction model for sepsis-related adverse outcome (infection-related ICU admission within seven days or infection-related death within 30 days) using logistic regression, random forest, and neural network machine learning techniques. Data from 2017 and 2018 were used for derivation and from 2019 for validation.

Results
We included 155,486 patients (median age of 51 years; 59% females) in the analyses. The strongest predictors for sepsis-related adverse outcome were age, type of contact (home visit or clinic consultation), patients considered ABCD unstable during triage, and the entry complaints”general malaise”, “shortness of breath” and “fever”. The multivariable logistic regression model resulted in a C-statistic of 0.89 (95% CI 0.88–0.90) with good calibration. Machine learning models performed similarly to the logistic regression model. A “sepsis alert” based on a predicted probability >1% resulted in a sensitivity of 82% and a positive predictive value of 4.5%. However, most events occurred in patients receiving home visits, and model performance was substantially worse in this subgroup (C-statistic 0.70).

Conclusion
Several patient characteristics identified during telephone triage of patients presenting to out-of-hours GP cooperatives were associated with sepsis-related adverse outcomes. Still, on a patient level, predictions were not sufficiently accurate for clinical purposes.
The effect of plant size on the phytoliths characteristics of short cells in the leaf epidermis of Dactylis glomerata L.
Authors: Solomonova M. Yu. , Zhembrovskaya T. A. , Lyashchenko A. D. , Kotov S. D. 
Published: December 2023

The present study is devoted to the revision of the influence of plant organs size on the size of phytoliths. Phytolith size parameters are used to identify cultivated grasses species in archaeological sites. Understanding how these characteristics are variable is necessary in such studies. The study of the variability of the phytoliths morphometric parameters will increase the possibilities of their use in plant systematics. The article presents a correlation analysis between the average values of the morphometric characteristics of Dactylis glomerata phytoliths from six different habitats with leaf sizes and generative shoots. The cock’s-foot specimens from forest, meadow and anthropogenically disturbed plant communities in the mountainous and plain parts of the south of Western Siberia were studied. Extraction of phytoliths was carried out using dry ashing. The measurement was made using the ImageJ software. Past 4.03 programs was used for statistical processing. The influence of the leaf length on the average values of the parameters of width, equivalent diameter, and inscribed radius of phytoliths of short epidermal cells of leaf was revealed. With an increase in the size of the leaf, the width of the phytolith and the parameters associated with it increase. The length of phytoliths, their area, perimeter, area and perimeter of the described figures weakly depend on the size of the vegetative organs of plants.
Key words. Crenate, Dactylis glomerata, morphometry, phytoliths, short cells.
Features of biology and coenopopulation characteristics of Silene cretacea Fisch. ex Spreng. on the Ilovli river valley, Volgograd region
Authors: Suprun N. A. 
Published: December 2023

One of the modern environmental problems is the reduction in the number of rare plant species due to an increase in anthropogenic pressure on natural phytocenoses. Cenopopulation studies of Silene cretacea Fisch. ex Spreng. will make it possible to study the real state of natural coenopopulations, which is the result of the intrapopulation distribution of individuals. We studied 7 cenopopulations of Silene cretacea in the natural conditions of the Volgograd region on the Cretaceous outcrops of the valley of the river Ilovlya, which differ in species composition and degree of anthropogenic impact. An ontogenetic strategy has been defined that corresponds to the S (patient) type, which allows the species, in the struggle for existence, due to its endurance, to exist in extremely unfavorable conditions, that is, in conditions where other species cannot survive, and therefore cannot compete with them. With the similarity of the age composition of cenopopulations in different ecological and cenotic areas, they differed from each other in terms of vitality composition. The vitality type of the studied cenopopulations changed from prosperous to depressive. The analysis of the age spectrum showed that all the studied populations are normal, incomplete, with a maximum in the generative fraction with a large proportion of plants of the generative period, with a small proportion of pregerative and senile individuals. For most individuals of the S. cretacea, normal development is common that described by the successive passage of individuals of all age states in their life cycle. Under optimal conditions, individuals of S. cretacea are characterized by slow development with slow rates of development in the middle generative age state. This is due to the specifics of the ecology of the habitat of S. cretacea (narrow ecological confinement, features of the soil substrate, etc.) and the biology of the species (seed renewal, prolonged stay of individuals in the generative state).
LET US RETHINK THE RE-THINK! PROJECT
Authors: Benko Andreja , Juvanec Borut 
Published: December 2023

The Re-think! heritage project is a venture funded by the European Union through the Erasmus+ program, focusing primarily on adult and higher education across various European countries. This initiative spans from January 2020 to December 2023, totalling 36 months with researches from 5 different countries included. The project's core emphasis lies in the realm of cultural heritage, exploring conservation approaches, recognizing excellence in renovations, and compiling a comprehensive vocabulary specific to cultural heritage.
The project mandates encompass a series of dissemination events in each partner country, widespread dissemination through social media channels, hosting meetings in partner countries, crafting an ebook detailing the project, and developing an eLearning platform. Throughout the project, researchers have been dedicated to the vital task of effectively disseminating their accumulated knowledge to the broader public.
A distinctive feature of this EU-sponsored project is its unwavering commitment to inclusivity. The entire project content, encapsulated within Re-think! heritage, has been thoughtfully translated into six languages, ensuring accessibility for a global audience. Through this holistic approach, the Re-think Heritage! Project aspires to redefine the methods of educating and involving individuals in heritage management and monument conservation, thereby cultivating a profound appreciation for our collective cultural legacy.
Every page and deliverable from the project is enriched with a wealth of visual materials, including photographs, sketches, simulations, drawings, technical illustrations, digital presentations, and more. These elements serve to enhance comprehension and provide the interested public with a vivid and immersive learning experience.
Educación de adultos y psicología evolutiva en la transferencia de la DINEA a la Provincia de Entre Ríos entre 1980-1982
Authors: Facciano Jonatan Ruben 
Published: December 2023

En este trabajo, inscripto dentro de la historia de la educación y la historia reciente de la Provincia de Entre Ríos, me propongo indagar en los cambios y continuidades en que se inscribe la transferencia a la provincia de Entre Ríos entre los años 1980-82 de los servicios educativos de la Dirección Nacional de Educación del Adulto (DINEA) enmarcado en un contexto de tensiones internas dentro de la Fuerzas Armadas (FFAA), con la mayor participación de los actores civiles del Proceso de Reorganización Nacional (PRN) y de consolidación del modelo económico y social Neoliberal. En este contexto, las FFAA construyen su rol como actor político en el ensayo de políticas educativas afines a criterios educativos vinculados a su propia estructura de formación y como alternativa a los lineamientos curriculares preexistentes, que daban sentido a la Educación de Adultos, para poder enmarcarla dentro del proceso disciplinador de las Doctrinas de Seguridad Nacional.
Product Differentiation and Trade
Authors: Pi Jiancai , Fan Yanwei 
Published: December 2023

Abstract
This paper analyzes the impacts of product differentiation in general oligopolistic equilibrium with trade. With constant wages, when product differentiation increases, the extensive margins of home and foreign exports decrease, and the domestic and foreign scopes of variety in each industry increase unambiguously. However, the impact of product differentiation on the labor requirement of each firm is mixed. In general equilibrium, an increment of product differentiation increases the wage rate unambiguously if the total variety of goods is large enough in all industry. However, if all firms are single-product ones, an increment of product differentiation increases the wage rate unambiguously in general equilibrium.
Image Acts of the Virgin of Vladimir
Authors: Yu Runsheng 
Published: December 2023

Abstract
The Virgin of Vladimir is one of the most historically, artistically, and religiously significant icons in Russia. From an art historical perspective, it belongs to the category of Eleusa icons, using vivid depictions of the mother-child relationship to convey religious doctrine. It represents the highest level of 12th-century Byzantine and Russian religious art. From the perspective of image act, this icon’s pluralistic nature challenges the conventional notion of a work of art having a singular and authentic identity, as well as the idea of aesthetic contemplation. The icon’s mobile characteristics not only explain various miracle legends associated with icons but also provide insights into image act theory. Furthermore, analyzing the image act of this icon can contribute to a deeper understanding of the theories proposed by Bredekamp, distinguishing between passive act in non-autonomous images and active acts in autonomous images.
Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population
Authors: Deva Reka , Rajendran Priyadharsini , Ramasamy Sivaranjini , Selvan Senthamizh , Ramasamy Kesavan 
Published: December 2023

Abstract

Objectives
Azathioprine (AZA) is an effective immunosuppressant commonly used for malignancy and immune-mediated disorders. The association between genetic polymorphisms and AZA-induced adverse effects has not been elucidated. Hence this study aimed to evaluate the relationship between single nucleotide polymorphisms of ITPA (C94A) with azathioprine-induced adverse effects.

Methods
A cross-sectional study was performed on 120 patients who were on AZA therapy for immunobullous disorders and inflammatory bowel disease (IBD). Eligible patients were enrolled from outpatient Departments of dermatology and medical gastroenterology and five mL of blood was collected after obtaining written informed consent. DNA extraction and genotyping were done by phenol–chloroform method and real-time polymerase chain reaction (RT-PCR), respectively.

Results
The minor allele frequency of ITPA (A allele) was 30.8 %. The mutant genotypes of ITPA (C94A) were found to have no significant association with overall adverse effects in the South Indian patients on AZA therapy.

Conclusions
We report no significant association between ITPA rs1127354 genetic polymorphism and adverse effects in the South Indian patients on AZA therapy.
The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent
Authors: Kayati Fitri Nur , Purnomo Chandra Wahyu , Kusumastuti Yuni , Rochmadi  
Published: December 2023

Abstract
The mechanical properties of hydrogels are crucial in wound dressing application. Starch-based hydrogels have deficiencies in mechanical strength and gel stability. These shortcomings can be addressed by employing crosslinking techniques with oxidized sucrose. A design of experiments approach was used to optimize the tensile strength of the product. The results indicated that both the composition of oxidized sucrose and glycerol significantly impact tensile strength (p-value < 0.05). The optimal tensile strength achieved was 27 MPa, using 0.9762 mL of oxidized sucrose and 0.0624 g of glycerol per gram of starch. The hydrogel products underwent a series of characterizations, including optical microscope examination, Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance (1H NMR), swelling test, Water Vapor Transmission Rate (WVTR), contact angle, and cytotoxicity test. The FTIR and 1H NMR analyses confirmed the crosslinking of hydroxyl groups within starch molecules with aldehyde groups from oxidized sucrose. Characterization of this hydrogel revealed that it had a swelling capacity of 95%, a WVTR of 714.92 g per m2 per 24 h, a contact angle of 74.76°, and a cell viability value greater than 100%. Thus, this hydrogel is suitable for wound dressing due to its strength, exudate-absorbing capabilities, moisture retention properties, hydrophilicity, and non-toxicity.
The Chaîne Opératoire Approach for Interpreting Personal Ornament Production: Marble Beads in Copper Age Tuscany (Italy)
Authors: Vassanelli Alice , Petrinelli Pannocchia Cristiana , Starnini Elisabetta 
Published: December 2023

Abstract
This article discusses the chaîne opératoire concept in prehistoric archaeology, traditionally employed for the study of lithic industries and ceramic production, and focuses on personal ornament manufacture. This category of non-functional objects has been analysed with the operational sequence approach in the framework of a research project aimed at the techno-functional study of prehistoric marble artefacts. Throughout an experimental approach, the study presents the actions and choices made by the artisans to produce marble beads and tries to understand the role and social-cultural meaning that these items had for the Copper Age communities in Tuscany. Finally, our study proved that the beginning of the use of the Apuan marble can be traced back to the sixth millennium BC, and it was connected with the production of personal ornaments, reaching its peak during the Copper Age.
What is long-term survival in patients with peritoneal metastasis from gastric, pancreatic, or colorectal cancer? A study of patients treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Authors: Kryh-Jensen Charlotte G. , Fristrup Claus W. , Ainsworth Alan P. , Detlefsen Sönke , Mortensen Michael B. , Pfeiffer Per , Tarpgaard Line S. , Graversen Martin 
Published: December 2023

Abstract

Objectives
A definition of long-term survival (LTS) in patients with peritoneal metastasis (PM) from gastric cancer (GC), pancreatic cancer (PC) or colorectal cancer (CRC) treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC) is lacking. We aimed to define LTS and investigate characteristics and treatment response in patients who reached LTS in data from two prospective trials.

Methods
Retrospective study of patients with GC-, PC-, or CRC-PM from the prospective PIPAC-OPC1 and PIPAC-OPC2 studies. The definition of LTS was based on published systematic reviews and randomized controlled trials. LTS was defined at the time point where 25 % of the patients were alive in these studies. Histology based response was evaluated by the mean Peritoneal Regression Grading Score (PRGS) using biopsies obtained prior to PIPAC 3, and defined by a mean PRGS of ≤2.0 or a decrease of mean PRGS of ≥1, compared to baseline.

Results
LTS was defined at 21 (GC), 15 (PC), and 24 (CRC) months. Fifty-one (47.2 %) patients (nine GC, 17 PC, 25 CRC) reached LTS calculated from the date of PM diagnosis. All but one received palliative chemotherapy before PIPAC, and 37 % received bidirectional treatment. More than 90 % of the LTS patients had response according to PRGS. The mOS from PIPAC 1 was 23.3, 12.4, and 28.5 months for GC, PC, and CRC LTS patients.

Conclusions
Patients with PM from GC, PC, and CRC treated with systemic chemotherapy and PIPAC can reach LTS and most show histological response. Causality must be further investigated.
The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer
Authors: Stein Mark S , Kalff Victor , Williams Scott G , Murphy Declan G , Colman Peter G , Hofman Michael S 
Published: December 2023

Objectives
The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce in vitro proliferation and in vivo growth of prostate cancer cell lines. Primary human prostate cancer expresses the GLP-1 receptor (GLP-1R) in vitro. Cancer evolves with stage, and whether advanced-stage human prostate cancer expresses GLP-1R is unknown. We hypothesised and aimed to prove that human metastatic castrate-resistant prostate cancer (mCRPC) expresses the GLP-1R in vivo. We hypothesised that mCRPC would thus be detectable by positron emission tomography/computed tomography (PET/CT) using a radiotracer bound to a GLP-1R ligand, as in exendin PET/CT.

Materials and methods
Men with mCRPC, with more than one prostate-specific membrane antigen (PSMA)-avid lesion on PET/CT scanning (pathognomic in that setting for prostate cancer lesions), were approached to undergo PET/CT with gallium68-Dota-exendin-4. We documented PET/CT PSMA-avid lesions, which were also PET/CT exendin avid, as evidence of in vivo GLP-1R expression.

Results
Out of the 24 men referred, three did not meet the inclusion criteria. Seventeen declined, largely because the study offered them no therapeutic benefit. Among the four men imaged, three had no exendin-avid lesions, while one had six osseous PSMA-avid lesions, three of which were also exendin avid.

Conclusions
We demonstrated in vivo GLP-1R expression by human mCPRC, detecting PET/CT lesions avid for both PSMA and exendin, in one of four participants. GLP-1R expression may thus occur even in advanced-stage prostate cancer. Our data contribute to growing evidence supporting the testing of GLP-1 receptor agonists for therapeutic benefit in prostate cancer.
¿Clases sociales en la clase?
Authors: Unás Camelo Viviam Stella , Satizabal Reyes Melania 
Published: December 2023

Este artículo explora la manera en que las diferencias de clases sociales participan de las interacciones que docentes y estudiantes establecen en el aula. Se realizó una investigación cualitativa, a través de entrevistas en profundidad a un grupo de docentes de instituciones públicas y privadas de la ciudad de Cali. En concreto, se examinó el modo en que este grupo de docentes interpreta su posición de clase, la de sus estudiantes y las tensiones que estas posiciones diferenciadas suponen para el desarrollo del trabajo educativo. El estudio identificó tres tensiones: primero, el desafío de concebir a la Escuela como un dispositivo de movilidad social en regímenes de estratificación que, como el colombiano, presentan una movilidad restringida; el segundo, el reto de alimentar el entusiasmo respecto al trabajo educativo en contextos en los que se atribuye a los estudiantes un bajo capital ambicioso; por último, los efectos que el origen de clase de los estudiantes tiene sobre el estatuto y contenido del trabajo docente. A modo de conclusión, es notable el hecho de que para los docentes entrevistados la Escuela se presenta como una institución incapaz de revertir el régimen de distribución de las expectativas que las clases sociales instauran.
İŞKENCENİN ÖNLENMESİ BAĞLAMINDA HUKUKUN ÜSTÜNLÜĞÜ VE AHLAK İLİŞKİSİ
Authors: ÜNÜVAR Güneş Atay 
Published: December 2023

Lon L. Fuller'a göre hukuk, ancak insanları kendi düzenine tabi kılabilecek durumdaysa hukuk olabilir.
Bunu başarabilmek için hukuk, kişileri genel kurallar aracılığıyla yönetmeli ve bu kurallar ilan edilmiş,
anlaşılabilir, ileriye dönük, birbiriyle uyumlu, uygulanabilir, istikrarlı olmalı ve resmi işlemler ile ilan edilen
kurallar arasında bir örtüşme bulunmalıdır. Hukukun üstünlüğünün prensipleri olarak kabul edilen bu
sekiz ilke bir düzeni hukuk sistemine dönüştürmek için olmazsa olmazdır. Hukukun üstünlüğü, Fuller'ın
görüşünde, kişileri haysiyet sahibi failler olarak değerlendirdiğinden ve keyfi yönetimlerin ahlaki talepleri
ihlal etmeye yönelik uygulamalarını sınırlayabileceğinden ahlaki bir değer taşır. Hukuki pozitivistler ise bu
prensiplerle etik arasında zorunlu bir ilişki kurulamayacağını ileri sürerek hukukun üstünlüğünü araçsal bir
konuma indirgerler. Bu çalışmada ilk olarak Fuller'ın prosedürel doğal hukuk teorisiyle pozitivistlerin karşı
argümanları değerlendirilmekte, daha sonra Bush yönetiminin soruşturmalarda işkence yöntemleri
kullanabilmesinin ancak Fuller'ın ortaya koyduğu prensiplerin ihlali ile mümkün olduğu ortaya konarak
hukukun üstünlüğünün işkencenin önlenmesi bağlamında ahlaki değeri haiz olduğu savunulmaktadır