bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phylogeny and ultrastructure of Elthusa raynaudii (Isopoda, Cymothoidae) firstly recorded from the invasive silver cheeked toadfish (Lagocephalus sceleratus) (Gmelin 1789) in eastern Mediterranean Sea coast
Authors: Mahmoud Nisreen E. , Fahmy Magdy M. , Khattab Marwa S. , Abuowarda Mai 
Published: January 2024

AbstractWith the opening of the Suez Canal in 1869, many changes have occurred in the Mediterranean Sea ecosystem so became a home to many invasive Lessepsian marine species that have migrated from the Red Sea. About 500 marine species including pufferfish have immigrated and rapidly established a population in the Mediterranean Sea causing significant impact on its ecosystem and fisheries sector. The parasitic fauna of these pufferfish has scarcely been studied in the Mediterranean Sea and also in their native habitat. During this surveillance study on the invasive pufferfish species from the Egyptian Mediterranean coast, the female cymothoid isopod Elthusa raynaudii was detected from the branchial cavity and also in the buccal cavity of 23.9% of the examined Lagocephalus sceleratus. The isolated isopod species was firstly identified and described through electron microscopy and molecular phylogeny based on the sequences of mitochondrial 16S rRNA gene. Additionally, the description of eggs, embryonic stage, and manca of E. raynaudii was firstly provided. The pathological impact on the infested fish tissues was investigated and revealed curling and loss of secondary gill lamellae in addition to mucous exudates in between the gill filaments and granuloma formation in the gill arch. The study provided the first report of L. sceleratus as a new host for the isopod E. raynaudii collected from the Egyptian Mediterranean coast as a new locality record. The role of the Lessepsian invasive pufferfish in transmitting parasites to the native fish species was discussed.
Graphical Abstract
The influence of alteration and fractures on gas permeability and mechanical properties of the sedimentary and volcanic rocks of the Acoculco Caldera Complex (México)
Authors: Ramírez-Guzmán Ángel , Pola Antonio , Macias José Luis , Soto-Herrera Andrés Mauricio , Avellán Denis Ramón , Pacheco-Valdovinos Pedro Martín , Martínez-Martínez Javier 
Published: January 2024

AbstractPetrophysical and mechanical properties of limestones and volcanic altered and unaltered rocks were estimated by a series of laboratory measurements. The aim of this work was to study the changes in matrix permeability and the influence of an induced vertical fracture. The phenomenon was studied by direct comparison of different properties (porosity, UCS, permeability) and by a multiple linear regression analysis. Porosity, UCS, and matrix permeability of limestones and non-altered volcanic rocks showed homogeneous values. However, the permeability increased from poor to moderate after fracture induction (10–17 to 10–14 m2). Altered volcanic specimens showed a more complex pore system. Thus, considerable variations in all measured properties were identified. For example, porosity ranged from 6 to 50% and Permeability ranged from 10–14 to 10–12 m2. Comparison plots including UCS, porosity, and matrix permeability showed a good fitting (R2=0.75). Multiple linear regression analysis in fractured specimens has a moderate R2 (0.55) The model that better explains the permeability evolution of fractured specimens has the fracture permeability as the response variable and the porosity values as independent variables. The usage and repeatability of these equations in other zones should include more singularities of every single specimen as pore size, pore distribution, and fractures.
Study delay during emergency remote teaching among students at Dutch universities: the role of students’ education satisfaction and academic wellbeing
Authors: Vollmann Manja , Scheepers Renée A. , Hilverda Femke 
Published: January 2024

AbstractThis study investigated whether the amount of emergency remote teaching (ERT) was negatively associated with students’ academic performance in terms of study delay and explored whether this association was mediated by study-related experiences, i.e. students’ education satisfaction and subsequently academic wellbeing (academic burnout and academic engagement). The study was conducted during the academic year 2020/2021 and 680 students from all conventional Dutch universities participated. The amount of ERT and study-related experiences were measured at three time points throughout the academic year and the respective scores were averaged for data analysis. Study delay was assessed at the end of the academic year (last time point). The hypothesised model was tested using path analysis. A higher amount of ERT was associated with a higher risk of study delay and this association was mediated by study-related experiences in two ways. First, a higher amount of ERT was related to lower education satisfaction, which in turn increased the risk of study delay. Second, a higher amount of ERT was related to lower education satisfaction, which in turn was associated with lower academic wellbeing, i.e. more academic burnout and less academic engagement, which in turn increased the risk of study delay. The findings suggest that education satisfaction and academic wellbeing are mechanisms underlying the detrimental effect of ERT on study performance, with education satisfaction playing a central role. To avoid students incurring study delay, universities are advised to implement ERT and online education in general in such a way that students’ education satisfaction gets preserved.
Rapid recovery of invasive wild pig (Sus scrofa) populations following density reduction
Authors: Garabedian James E. , Kilgo John C. 
Published: January 2024

AbstractTrapping is an effective strategy for control of invasive wild pig (Sus scrofa), but eradication of populations via trapping alone typically is impractical throughout much of the species’ introduced range. Consequently, recovery of wild pig populations to pre-trapping levels following control is a major impediment to success of long-term control. In this study, we conducted camera-trap surveys to monitor recovery of two wild pig populations immediately following density reductions achieved via trapping on two sites on the Savannah River Site, SC. We used spatial capture-recapture models to estimate wild pig density during seven 3 week periods spanning 12 months to: (1) determine the time required for populations to recover to pre-trapping levels; and (2) evaluate trends in population growth, density, and distribution during recovery. Recovery of both wild pig populations started immediately after trapping ceased, with populations reaching pre-trapping levels in 3 and 5 months. Threeweek population growth rates for each wild pig population during recovery averaged 1.28 (range = 1.11–1.39 on site 1) and 1.24 (range = 0.64–1.92 on site 2), which corresponded to a 345% and 132% increase in abundance (an increase of 141 and 126 individual wild pigs on site 1 and 2, respectively) of each population by the last survey period. Rapid recovery and growth beyond pre-trapping levels of wild pig populations likely were driven by residual wild pigs not removed by trapping and compensatory reproduction and immigration. Our study is one of the first to provide information on how quickly wild pig populations can recover following overall density reductions of 54–68% and indicates practitioners should be prepared to reinitiate trapping efforts in as little as 3 months to prevent recovery of wild pig populations following control.
Testimony of Oppression and the Limits of Empathy
Authors: Sodoma Katharina Anna 
Published: January 2024

AbstractTestimony of oppression is testimony that something constitutes or contributes to a form of oppression, such as, for example, “The stranger’s comment was sexist.” Testimony of oppression that is given by members of the relevant oppressed group has the potential to play an important role in fostering a shared understanding of oppression. Yet, it is frequently dismissed out of hand. Against the background of a recent debate on moral testimony, this paper discusses the following question: How should privileged hearers approach testimony of oppression if they aim to do so in an ethically and epistemically sound way? Should they defer or try to understand? Both strategies constitute ways of learning from testimony of oppression. However, they differ in important respects and exclude each other. Because testimony of oppression is often based on personal experience, empathizing with the speaker can play an important role in trying to understand testimony of oppression. While the fact that empathy can change your mind and the advantages of understanding over knowledge support trying to understand as the right approach to testimony of oppression, considerations of the “limits of empathy” and the value of deference support deferring. I argue that, on balance, these contrasting arguments allow for a limited defense of the role of empathy in learning from testimony of oppression. We should try to understand testimony of oppression by empathizing with the speaker, but not treat our ability to understand as a condition on accepting a speaker’s claim.
Bread making quality parameters of some Ukrainian and Polish triticale cultivars
Authors: Kaszuba Joanna , Woś Henryk , Shchipak Gienadii V. 
Published: January 2024

AbstractGrain, flour and bread quality parameters were investigated in one Polish and three Ukrainian triticale cultivars, selected as the most suitable for production of bread. The studies revealed large differences in some bread-making parameters. The farinographic parameters of the Ukrainian triticale cultivars were not worse than those of wheat, but the bread loaf volume was lower. The best triticale bread was obtained from the Polish cultivar Panteon, loaf volume and crumb porosity were the highest, in spite of weak results of the farinographic test. Reliability of parameters used for prediction of wheat bread quality in application to triticale is discussed. The laboratory baking is recommended for bakers, breeders and for cultivar testing as the safest method of the evaluation.
Unravelling the Electrical Conductivity of Earth and Planets
Authors: Grayver Alexander 
Published: January 2024

AbstractThis review presents the progress made in the last decade in the field of large-scale electromagnetic (EM) induction with natural sources, which fluctuate at periods from seconds to years and originate in oceans, ionosphere and magnetosphere. These mechanisms produce field variations that can be used to image subsurface electrical structure of Earth and planets across scales and depths from the shallow crust to the lower mantle. In the last decade, we have seen a substantial progress made in different areas related to methods, observations and 3-D numerical modelling of EM phenomena at crustal and mantle scales. Specifically, new methods for handling complex ionospheric and magnetospheric sources were proposed, accompanied by more efficient forward and inverse modelling tools that allowed us to combine several broadband sources and constrain electrical conductivity on multiple scales simultaneously. Magnetic signals due to oceanic tides were established as a new source to probe conductivity of the sub-oceanic upper mantle. Further, the launch of ESA Swarm satellites in 2013 and their successful ongoing operation have marked a new era in the field of large-scale EM induction, unlocking a set of new opportunities, but also posing new challenges. These developments were backed by new lab measurements of electrical conductivity for mantle minerals at temperatures and pressures that are getting closer to the relevant pressure and temperature conditions in the mantle, alleviating the need for inaccurate extrapolations. The latter enabled more plausible quantitative estimates of water content, melt fractions and temperature in the mantle. In parallel, crust and mantle conductivity models along with developed modelling techniques have become an integral part of geomagnetic field and geomagnetically induced currents (GICs) modelling workflows, establishing new inter-disciplinary knowledge domains.
Optimizing non-invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non-invasive PGT-A results
Authors: Chow Judy F. C. , Lam Kevin K. W. , Cheng Heidi H. Y. , Lai Shui Fan , Yeung William S. B. , Ng Ernest H. Y. 
Published: January 2024

Abstract
Purpose
This study aimed to optimize the non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) in the laboratory by comparing two collection timing of the spent culture medium (SCM), two embryo rinsing protocols, and the use of conventional insemination instead of intracytoplasmic sperm injection (ICSI).

Methods
Results of two embryo rinsing methods (one-step vs sequential) and SCM collected on day 5 vs day 6 after retrieval were compared against trophectoderm (TE) biopsies as reference. Results from day 6 SCM in cycles fertilized by conventional insemination were compared with PGT-A using ICSI.

Results
The rate of concordance was higher in day 6 samples than in day 5 samples when the sequential method was used, in terms of total concordance (TC; day 6 vs day 5: 85.0% vs 60.0%, p = 0.0228), total concordance with same sex (TCS, 82.5% vs 28,0%, p < 0.0001), and full concordance with same sex (FCS, 62.5% vs 24.0%, p = 0.0025). The sequential method significantly out-performed the one-step method when SCM were collected on day 6 (sequential vs one-step, TC: 85.0% vs 64.5%, p = 0.0449; TCS: 82.5% vs 54.8%, p = 0.0113; FCS: 62.5% vs 25.8%, p = 0.0021). There was no significant difference in niPGT-A results between cycles fertilized by the conventional insemination and ICSI.

Conclusion
We have shown a higher concordance rate when SCM was collected on day 6 and the embryos were rinsed in a sequential manner. Comparable results of niPGT-A when oocytes were fertilized by conventional insemination or ICSI. These optimization steps are important prior to commencement of a randomized trial in niPGT-A.
Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
Authors: Chen Jinghua , Liu Jie , Liu Xiaolin , Wang Jun , Wang Xiumei , Ye Xin , Xie Qi , Liang Jing , Li Yan 
Published: January 2024

Abstract

Background
PD-1 blockade has shown impressive clinical outcomes in colorectal cancers patients with high microsatellite instability (MSI-H). However, the majority of patients with colorectal cancer who present low microsatellite instability (MSI-L) or stable microsatellites (MSS) show little response to PD-1 blockade therapy. Here, we have demonstrated that Shikonin (SK) could induce cell death of CT26 cells via classically programmed and immunogenic pathways.

Methods and results
SK promoted the membrane exposure of calreticulin and upregulated the expression of heat shock protein 70 (Hsp70). The upregulation of Hsp70 was dependent on ROS induced by SK and silencing of PKM2 in CT26 cells reverts ROS upregulation. Besides, SK synergizes with PD-1 blockade in CT26 tumor mice model, with the increase of intramural DC cells and CD8+ T cells. The expression of Hsp70 in tumor tissue was also increased in combinational SK plus αPD-1 therapy group.

Conclusions
Our study elucidated the potential role of ‘Shikonin-PKM2-ROS-Hsp70’ axis in the promotion of efficacy of PD-1 blockade in CRC treatments, providing a potential strategy and targets for improving the efficacy of PD-1 blockade in colorectal cancer.
Shank3 Deficiency Results in a Reduction in GABAergic Postsynaptic Puncta in the Olfactory Brain Areas
Authors: Mihalj Denisa , Borbelyova Veronika , Pirnik Zdeno , Bacova Zuzana , Ostatnikova Daniela , Bakos Jan 
Published: January 2024

AbstractDysfunctional sensory systems, including altered olfactory function, have recently been reported in patients with autism spectrum disorder (ASD). Disturbances in olfactory processing can potentially result from gamma-aminobutyric acid (GABA)ergic synaptic abnormalities. The specific molecular mechanism by which GABAergic transmission affects the olfactory system in ASD remains unclear. Therefore, the present study aimed to evaluate selected components of the GABAergic system in olfactory brain regions and primary olfactory neurons isolated from Shank3-deficient (−/−) mice, which are known for their autism-like behavioral phenotype. Shank3 deficiency led to a significant reduction in GEPHYRIN/GABAAR colocalization in the piriform cortex and in primary neurons isolated from the olfactory bulb, while no change of cell morphology was observed. Gene expression analysis revealed a significant reduction in the mRNA levels of GABA transporter 1 in the olfactory bulb and Collybistin in the frontal cortex of the Shank3−/− mice compared to WT mice. A similar trend of reduction was observed in the expression of Somatostatin in the frontal cortex of Shank3−/− mice. The analysis of the expression of other GABAergic neurotransmission markers did not yield statistically significant results. Overall, it appears that Shank3 deficiency leads to changes in GABAergic synapses in the brain regions that are important for olfactory information processing, which may represent basis for understanding functional impairments in autism.
The impact of public infrastructure investment on South Africa’s economy: evidence from social accounting matrix and computable general equilibrium-based approaches
Authors: Mbanda Vandudzai , Bonga-Bonga Lumengo 
Published: January 2024

AbstractThis paper assesses the general equilibrium impacts of public infrastructure investment in the South African economy, as a case of an emerging economy, by making use of complementary general equilibrium models, such as the social accounting matrix (SAM) multiplier, the Structural Path Analyses (SPA) and the Computable General Equilibrium (CGE) models. Contrary to studies that use partial equilibrium models, this paper shows the importance of an economy-wide model to analyse the effects of public infrastructure investment in an emerging economy. The results of the analysis, based on the SAM and CGE analyses using a 2015 SAM for South Africa, indicate that increasing public economic infrastructure can be an effective way of stimulating the economy in a way that has a positive impact on labour. SPA shows that the leading and most important path of influence is the direct influence of the public infrastructure investment on each formal labour category. However, because the public infrastructure investment does not employ informal labour, this labour account is only indirectly connected via intermediate consumption of the output of the construction sector. These results suggest that an increase in public economic infrastructure could help address the unemployment problem that exacerbates poverty in South Africa.
Quality and quantity: How contexts influence the emergence of teacher bias
Authors: Doyle Lewis , Harris Peter R. , Easterbrook Matthew J. 
Published: January 2024

AbstractA growing body of research has demonstrated that teachers’ judgements may be biased by the demographics and characteristics of the students they teach. However, less work has investigated the contexts in which teachers may be most vulnerable to bias. In two pre-registered experimental studies we explored whether the quality of students’ work, and the cognitive load placed on the grader, would influence the emergence of biases relating to socioeconomic status (SES) and ethnicity. In Study 1, teachers (N = 397) graded work of either high or low quality that had ostensibly been written by a student who varied in terms of SES and ethnicity. We found that SES and—to a lesser extent—ethnicity biases were more likely to manifest when the standard of work was below average, largely favouring a student from an affluent White background. In Study 2, an undergraduate sample (N = 334) provided judgements based on an identical piece of work written by a student who varied by SES and ethnicity. Importantly, they formulated these judgements whilst working under high or low cognitive load, which was manipulated via a simultaneous listening task. Results showed that under high cognitive load, a student from an affluent White British background was afforded a boost in grading that was not afforded to Black Caribbean and/or lower SES students. These findings highlight contexts in which teachers may be most prone to biased judgements and should be used by educational institutions to de-bias their workflows, workloads and workforces.
A naturalist approach to social ontology
Authors: Kincaid Harold 
Published: January 2024

AbstractI argue that a certain kind of naturalist approach to social ontology is likely to be both philosophically fruitful and relevant to empirical social science. The kind of naturalism I employ might be called contextualism, which emphasizes the constant presence of assumed background knowledge, is suspicious of general inference rules and all or nothing claims about the ontology of the social sciences, and argues that Quine’s quantificational criterion for ontological commitment has to be supplemented with local interpretations and arguments about what specific social science research is committed to. I look at three case studies employing this perspective, one on agent based models and individualism, a second on the reality of social class, and a third on the reality of race. In all three cases work is first needed to clarifying what empirical social science is claiming, what ontology or ontologies it seems to presuppose, and then description of the kinds of evidence that supports its commitments.
Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence
Authors: Ungvari Anna , Kiss Tamas , Gulej Rafal , Tarantini Stefano , Csik Boglarka , Yabluchanskiy Andriy , Mukli Peter , Csiszar Anna , Harris Melissa L. , Ungvari Zoltan 
Published: January 2024

AbstractHair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as stress, environmental toxicants, and radiation exposure. Understanding the mechanisms underlying hair graying is an ideal approach for developing interventions to prevent or reverse age-related changes in regenerative tissues. Hair graying induced by ionizing radiation (γ-rays or X-rays) has emerged as a valuable experimental model to investigate the molecular pathways involved in this process. In this review, we examine the existing evidence on radiation-induced hair graying, with a particular focus on the potential role of radiation-induced cellular senescence. We explore the current understanding of hair graying in aging, delve into the underlying mechanisms, and highlight the unique advantages of using ionizing-irradiation–induced hair graying as a research model. By elucidating the molecular pathways involved, we aim to deepen our understanding of hair graying and potentially identify novel therapeutic targets to address this age-related phenotypic change.