bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KESULITAN MEMBACA SISWA KELAS IV MADRASAH IBTIDAIYAH DARURRAHMAN KERTANEGARA INDRAMAYU
Authors: Atmam Qorinatul , Kartini  , Mardani Dadan 
Published: January 2024

Kesulitan membaca merupakan salah satu hambatan bagi siswa dalam belajar dimana siswa tidak dapat belajar secara maksimal. Siswa kelas IV pada dasarnya mampu menguasai keterampilan membaca dengan mudah karena membaca merupakan aktivitas yang dilakukan siswa untuk dapat mengenal huruf dan bacaan, akan tetapi fakta dilapangan masih ada siswa yang belum bisa membaca dan mengalami kesulitan dalam membaca, walaupun demikian belum terlambat untuk melakukan perbaikan dengan memberikan penanganan yang tepat dan baik kepada siswa. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor apa saja dalam kesulitan membaca siswa kelas IV Madrasah Ibtidaiyah Darurrahman Kertanegara Indramayu. Penelitian ini menggunakan pendekatan kualitatif yang bersifat deskriptif untuk meneliti pada kondisi obyek yang alamiah. Objek yang diteliti adalah orang tua siswa, guru kelas dan siswa kelas IV Madrasah Ibtidaiyah. Adapun teknik pengumpulan data yang digunakan ialah wawancara secara langsung pada orang tua dan siswa, dokumentasi dalam penelitian ini berupa gambar pada saat proses penelitian, dan juga observasi melihat kondisi siswa secara langsung pada saat proses pembelajaran. Hasil penelitian menunjukkan bahwa: 1) faktor-faktor permasalahan kurang lancar membaca siswa kelas IV. 2) faktor yang mempengaruhi siswa kesulitan dalam membaca yaitu siswa kurang minat membaca, kurang fokus atau kurang konsentrasi saat mengikuti pembelajaran, lingkungan keluarga yang kurang kondusif.
Auriculoterapia em gestantes: uma prática singular no manejo dos desconfortos gravídicos
Authors: Antunes Menezes Mariana , Sperli Geraldes Soler Zaida Aurora , Spadacio Cristiane , Chichetti de Amorim Paulo Fernando 
Published: January 2024

A Auriculoterapia apresenta diversas formas de aplicação e resulta no alívio de desconfortos físicos e emocionais. Este artigo tem como objetivo analisar a percepção das gestantes quanto à eficácia da Auriculoterapia na diminuição de queixas gestacionais. A pesquisa estrutura-se metodologicamente em dois eixos: primeiro com a construção de estudo clínico a partir da elaboração de protocolo de atendimento, e um segundo eixo qualitativo, seguindo pressupostos das pesquisas em saúde segundo Minayo (2002), para analisar a percepção das mulheres em relação ao protocolo aplicado. O estudo foi realizado em clínica particular de atenção humanizada ao nascimento. A amostra foi constituída por dez gestantes, mas quatro finalizaram o tratamento. O projeto foi encaminhado, analisado e aprovado pelo Comitê de Ética em Pesquisa (CEP) da Faculdade de Medicina de São José do Rio Preto (FAMERP), sob o parecer nº 5.867.915 e CAAE: 64241322.4.0000.5415. Foi utilizado o protocolo de auriculoterapia para dor lombar-ciática (Shenmen- Rim- Simpático- Quadril- Ciático). Quanto às percepções das participantes sobre o tratamento de Auriculoterapia, destacou-se no discurso uma melhora progressiva das queixas em todas as participantes. A Auriculoterapia mostrou-se eficaz no manejo da dor lombar, ciática, azia e ansiedade, sendo uma prática de valor na promoção da saúde na gestação.
Wilcoxon's Method in Determining The Effect of Using Discovery Learning Learning Strategies on The Learning Outcomes Of Vocational Basic DPIB Grade X Students.
Authors: Suharry  , Ambiyar  , Mahesi Agni Zaus  
Published: January 2024

One of the Discovery Learning Learning strategies is one of the efforts made by teachers to improve student learning outcomes by providing opportunities for students to learn on their own from various sources they like. The purpose of this study is to determine the effect of using discovery learning strategies on learning outcomes. In this study, the author used an experimental method with a type of quantitative research using SPSS which focuses on the Wilcoxon test to analyze data and answer research results. The respondents in this study amounted to 35 DPIB grade X students at SMK Negeri 2 Sungai Penuh. Based on the results of the Wilcoxon test, the results of Asymp Sig 0.0 2 where < of 0.05 means that this indicates that there is an influence of the use of discovery learning strategies on the learning outcomes of Basic Vocational Education of grade X DPIB students.
Combined microbiome and metabolomics analysis of Taorong-type baijiu high-temperature Daqu and medium-temperature Daqu
Authors: Liu Yanbo , Wu Junyi , Li Haideng , Liu Wenxi , Zhang Zhenke , Han Suna , Hou Jianguang , Pan Chunmei 
Published: January 2024

Background
Daqu is an essential starter for baijiu brewing in China. However, the microbial enrichment and metabolic characteristics of Daqu formed at different fermentation temperatures are still unclear.

Methods
High-throughput sequencing technology and the non-targeted metabolomics were used to compare the microbial communities and metabolites of Taorong-type high-temperature Daqu and middle-temperature Daqu. In this study, the relationship between microorganisms and metabolites was established.

Results
The study found that the composition and metabolites of the microbial community differed due to the difference in Daqu-making temperature. The bacterial diversity of Taorong-type high-temperature Daqu was higher than that of middle-temperature Daqu, while the fungal community diversity of Taorong-type middle-temperature Daqu was higher than that of high temperature Daqu. A total of 1,034 differential metabolites were screened from the two types of Daqu, and 76 metabolites with significant differences were detected (P < 0.001 and variable importance in projection (VIP) > 1.15). Tetraacetylethylenediamine is the metabolite with the largest differential fold among the 76 differential metabolites, which can be used as a potential marker metabolite of high-temperature Daqu.

Conclusion
This study helps elucidate the microbial assembly mechanisms and functional expression under different processing conditions through a further understanding of the composition and metabolic profile differences of different types of Daqu microflora in Taorong-type baijiu.
Investigating Unnatural Deaths Linked to Sexual Assault: A Forensic Analysis
Authors: Roy Amal , Tasnim Zakia , Nargis Fahmida 
Published: January 2024

Background: Exploration of fatalities associated with sexual activity, encompassing both natural and unnatural occurrences, delving into elements such as physical strain and peculiar circumstances. Terminology like "dying in the saddle" is utilized to describe incidents during sexual intercourse. Although human sexuality is generally regarded as positive, it can, in some cases, result in fatal incidents. Natural deaths, often impacting males, are correlated with pre-existing medical conditions, including fatal cardiovascular events triggered by sexual exertion. Sexual violence, spanning from harassment to coerced penetration, remains a pervasive global issue. In Bangladesh, there are notable instances of sexual intimate partner violence against women.
Aim of the Study: The study aimed to represent the clinical characteristics and causes of unnatural death related to sexual assault.
Methods: This retrospective study, conducted at the Department of Forensic Medicine & Toxicology, Dhaka Medical College, Bangladesh, analyzed 15 autopsies over two years, from July 2021 to June 2023, focusing on suicides by hanging and poisoning. The research adhered to legal and ethical guidelines, obtaining informed consent from legal guardians. Inclusion criteria covered all ages and genders, with unnatural deaths related to sexual activities. Exclusion criteria included natural deaths. Cases were identified through autopsy records, additional examinations, police files, court proceedings, and input from witnesses. A team of five experienced forensic pathologists ensured an unbiased evaluation. Results were organized into tables and graphs, with statistical analysis using SPSS.
Results: This study analyzed 15 unnatural deaths, focusing on age distribution, gender, sexual assault patterns, locations, sexual activities, and causes of death. Victims aged 0-10 years constituted 46.67%, 11-20 years were 33.33%, and 21-30 years were 20.00%. Females comprised 93.33%. Sexual assaults occurred mainly by neighbors (40.00%), involved gang rape (20.00%), and stepfather rape (13.33%). Public places (33.33%) and other locations (40.00%) were common sites. The most prevalent type of injury was head trauma, accounting for 26.67%. Fatal injuries, burns, choking, and poisoning were equally significant, each contributing to 33.33% of cases. Falls from heights were identified as a major cause of death, comprising 20.00% of the reported incidents.
Conclusion: This research delves into the intricate aspects surrounding non-natural deaths occurring in the context of sexual activities, with a specific emphasis on suicides related to hanging and poisoning. It underscores the imperative for a nuanced comprehension of these incidents, drawing attention to possible misclassifications and advocating for precise forensic evaluations. The findings underscore the necessity for increased awareness, education, and preventive measures to confront the social and cultural determinants that contribute to sexual violence.
Effect of Seed Priming on Fodder Yield of Maize
Authors: Patel Harsh K. , Patel H. K. , Rathod P. H. , Raval C. H. , Dudhat D. H. 
Published: January 2024

The study on effect of seed priming on yield and quality of fodder maize was carried out at Main Forage Research Station, Anand Agricultural University, Anand during the rabi season 2020-21. The research comprised of ten treatments and four replications, and it was set up in a randomized block design. The results of the experiments revealed that different seed priming treatments failed to create a significant response on plant population per meter row length at 15 DAS, days to 50% flowering, and plant height at 20 DAS. The growth and yield attributes of fodder maize crop viz., periodical plant height at 40 DAS and at harvest, number of leaves per plant, leaf stem ratio, green fodder yield, dry fodder yield, dry matter, crude protein, acid detergent fiber and Neutral detergent fiber at harvest were significantly affected by different seed priming treatments and recorded significantly higher in treatment of Seed priming with ZnSO4 @ 0.5% for 6 hrs. and also reported maximum net realization with its BCR.
Genetic Risk Factors for Early-Onset Merkel Cell Carcinoma
Authors: Mohsin Noreen , Hunt Devin , Yan Jia , Jabbour Austin J. , Nghiem Paul , Choi Jaehyuk , Zhang Yue , Freeman Alexandra F. , Bergerson Jenna R. E. , Dell’Orso Stefania , Lachance Kristina , Kulikauskas Rima , Collado Loren , Cao Wenjia , Lack Justin , Similuk Morgan , Seifert Bryce A. , Ghosh Rajarshi , Walkiewicz Magdalena A. , Brownell Isaac 
Published: January 2024

ImportanceMerkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Of the patients who develop MCC annually, only 4% are younger than 50 years.ObjectiveTo identify genetic risk factors for early-onset MCC via genomic sequencing.Design, Setting, and ParticipantsThe study represents a multicenter collaboration between the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Allergy and Infectious Diseases (NIAID), and the University of Washington. Participants with early-onset and later-onset MCC were prospectively enrolled in an institutional review board–approved study at the University of Washington between January 2003 and May 2019. Unrelated controls were enrolled in the NIAID Centralized Sequencing Program (CSP) between September 2017 and September 2021. Analysis was performed from September 2021 and March 2023. Early-onset MCC was defined as disease occurrence in individuals younger than 50 years. Later-onset MCC was defined as disease occurrence at age 50 years or older. Unrelated controls were evaluated by the NIAID CSP for reasons other than familial cancer syndromes, including immunological, neurological, and psychiatric disorders.ResultsThis case-control analysis included 1012 participants: 37 with early-onset MCC, 45 with later-onset MCC, and 930 unrelated controls. Among 37 patients with early-onset MCC, 7 (19%) had well-described variants in genes associated with cancer predisposition. Six patients had variants associated with hereditary cancer syndromes (ATM = 2, BRCA1 = 2, BRCA2 = 1, and TP53 = 1) and 1 patient had a variant associated with immunodeficiency and lymphoma (MAGT1). Compared with 930 unrelated controls, the early-onset MCC cohort was significantly enriched for cancer-predisposing pathogenic or likely pathogenic variants in these 5 genes (odds ratio, 30.35; 95% CI, 8.89-106.30; P &amp;lt; .001). No germline disease variants in these genes were identified in 45 patients with later-onset MCC. Additional variants in DNA repair genes were also identified among patients with MCC.Conclusions and RelevanceBecause variants in certain DNA repair and cancer predisposition genes are associated with early-onset MCC, genetic counseling and testing should be considered for patients presenting at younger than 50 years.
Inpatient Costs of Treating Patients With COVID-19
Authors: Kapinos Kandice A. , Peters Richard M. , Murphy Robert E. , Hohmann Samuel F. , Podichetty Ankita , Greenberg Raymond S. 
Published: January 2024

ImportanceWith more than 6.2 million hospitalizations due to COVID-19 in the US, recognition of the average hospital costs to provide inpatient care during the pandemic is necessary to understanding the national medical resource use and improving public health readiness and related policies.ObjectiveTo examine the mean cost to provide inpatient care to treat COVID-19 and how it varied through the pandemic waves and by important sociodemographic patient characteristics.Design, Setting, and ParticipantsThis cross-sectional study used inpatient-level data from March 1, 2020, to March 31, 2022, extracted from a repository of clinical, administrative, and financial information covering 97% of academic medical centers across the US.Main Outcomes and MeasuresCost to produce care for each stay was calculated using direct hospital costs to provide care adjusted for geographic differences in labor costs using area wage indices.ResultsThe sample included 1 333 404 stays with a primary or secondary COVID-19 diagnosis from 841 hospitals. The cohort included 692 550 (52%) men, with mean (SD) age of 59.2 (17.5) years. The adjusted mean cost of an inpatient stay was $11 275 (95% CI, $11 252-$11 297) overall, increasing from $10 394 (95% CI, $10 228-$10 559) at the end of March 2020 to $13 072 (95% CI, $12 528-$13 617) by the end of March 2022. Patients with specific comorbidities had significantly higher mean costs than their counterparts: those with obesity incurred an additional $2924 in inpatient stay costs, and those with coagulation deficiency incurred an additional $3017 in inpatient stay costs. Stays during which the patient required extracorporeal membrane oxygenation (ECMO) had an adjusted mean cost of $36 484 (95% CI, $34 685-$38 284).Conclusions and RelevanceIn this cross-sectional study, an adjusted mean hospital cost to provide care for patients with COVID-19 increased more than 5 times the rate of medical inflation overall. This appeared to be explained partly by changes in the use of ECMO, which increased over time.
Clinical utility of a genetic diagnosis in individuals with cerebral palsy and related motor disorders
Authors: Santana Almansa Alexandra , Gable Dustin L. , Frazier Zoë , Sveden Abigail , Quinlan Aisling , Chopra Maya , Lewis Sara A. , Kruer Michael , Poduri Annapurna , Srivastava Siddharth 
Published: January 2024

AbstractObjectiveEvaluation of the clinical utility of a genetic diagnosis in CP remains limited. We aimed to characterize the clinical utility of a genetic diagnosis by exome sequencing (ES) in patients with CP and related motor disorders.MethodsWe enrolled participants with CP and “CP masquerading” conditions in an institutional ES initiative. In those with genetic diagnoses who had clinical visits to discuss results, we retrospectively reviewed medical charts, evaluating recommendations based on the genetic diagnosis pertaining to medication intervention, surveillance initiation, variant‐specific testing, and patient education.ResultsWe included 30 individuals with a molecular diagnosis and clinical follow‐up. Nearly all (28 out of 30) had clinical impact resulting from the genetic diagnosis. Medication interventions included recommendation of mitochondrial multivitamin supplementation (6.67%, n = 2), ketogenic diet (3.33%, n = 1), and fasting avoidance (3.33%, n = 1). Surveillance‐related actions included recommendations for investigating systemic complications (40%, n = 12); referral to new specialists to screen for systemic manifestations (33%, n = 10); continued follow‐up with established specialists to focus on specific manifestations (16.67%, n = 5); referral to clinical genetics (16.67%, n = 5) to oversee surveillance recommendations. Variant‐specific actions included carrier testing (10%, n = 3) and testing of potentially affected relatives (3.33%, n = 1). Patient education‐specific actions included referral to experts in the genetic disorder (30%, n = 9); and counseling about possible changes in prognosis, including recognition of disease progression and early mortality (36.67%, n = 11).InterpretationThis study highlights the clinical utility of a genetic diagnosis for CP and “CP masquerading” conditions, evident by medication interventions, surveillance impact, family member testing, and patient education, including possible prognostic changes.
Industrial internet process management and platform construction in intelligent manufacturing based on blockchain
Authors: Zhang Yan , Xiang Luoyong , Chen Wen 
Published: January 2024

AbstractThe current lack of effective means for information technology to penetrate into the intelligent manufacturing process of products has led to its disconnection from the core links of industrial systems and low efficiency. Therefore, a nonstandard mechanical product lifecycle model and an industrial internet platform data access mechanism have been proposed using blockchain technology, and an industrial internet platform has been constructed based on the two, which has been experimentally verified. The experimental results showed that the calculation methods in the model could overall reduce the average storage of abnormal data in blockchain products by 53.6%. In addition, the maximum time cost of scalar multiplication did not exceed 20 ms, which was lower than that of bi‐linear pairing. In the comparison of different schemes, the highest encryption computation cost of the research scheme did not exceed 100 ms, and the highest decryption computation cost did not exceed 200 ms, which was generally lower than the comparison scheme. At the same time, the max, mini, and average time consumption of encrypting order data during decryption operations were 5.74, 1.10, and 2.77 s, respectively. When the simulation request reached 2000, there were only a few exceptions on the platform server, indicating that it could support at least 2000 simultaneous requests from applications. Overall, the industrial internet process management platform constructed through research has high practicality and can meet the actual needs of intelligent manufacturing enterprises.
Iridium(III) Carbene Phosphors with Fast Radiative Transitions for Blue Organic Light Emitting Diodes and Hyperphosphorescence
Authors: Zheng Zhong , Wang Lu , Xin Yangyang , Wang Qi , Hong Xiangchen , Zhang Yuewei , Yiu Shek‐Man , Zhou Fan , Yan Jie , Zhang Dongdong , Duan Lian , Chi Yun 
Published: January 2024

AbstractIt is envisioned that the efficient and stable blue OLED phosphors can be synthesized using Ir(III) complexes with electron‐deficient carbene cyclometalates. Therefore, three facially coordinated Ir(III) phosphors f‐ct7a‐ c bearing isomeric purinylidene chelates are obtained. They possess three, two, and one 4‐t‐butylphenyl cyclometalate together with the same number of N‐phenyl appendage on carbene fragments, and exhibit photoluminescence centered (λmax) at 452‒461 nm, fast radiative rate constants (kr) of 7.5–11.3 × 105 s‒1, and high quantum yield (PLQY) up to 80% in degassed toluene at RT. Representative OLED based on f‐ct7c gives maximum external quantum efficiency (EQEmax) of 26.6%, CIE(x,y) of 0.16, 0.15, and low roll‐off with EQE of 22.3% at 1000 cd m‒2. Furthermore, they can be utilized to sensitize a deep blue multiple resonance thermally activated delay fluorescence emitter (MR‐TADF), i.e., t‐DABNA. The corresponding hyper‐OLED device based on alternative f‐ct7b realizes an EQEmax of 36.1%, CIE(x,y) of 0.14, 0.09, and full width at half maximum (FWHM) of 26.5 nm. To the understanding, this is the first report on concurrent achieving both the high EQE and small CIEy value for Ir(III)‐based phosphors.
A Strongly Robust Chitosan‐Based Programmed Control Functional Hydrogel Improved Mitochondrial Function and Pro‐Vascularization for Adaptive Repair of Myocardial Infarction
Authors: Li Zhentao , Li Qian , Cao Weidong , Zhan Jiamian , He Yutong , Xing Xianglong , Ding Chengbin , Wang Leyu , Qiu Xiaozhong 
Published: January 2024

AbstractHydrogel‐based engineered cardiac patches (ECP) hold great promise as potential treatment options for myocardial infarction (MI). However, optimizing the preparation of ECP with better biocompatibility, mechanical stability, and adaptation to MI repair remains a challenge. In this study, a chitosan (CS) hydrogel with good mechanical robustness through programmed control of hydrogen bonding is constructed to adapt to the continuous beating of myocardial tissue. With the synergistic effects of lipoic acid (TA), proanthocyanidins (PAs), and Eu3+, a functional platform capable of improving mitochondrial function, antioxidation, and pro‐vascularization is further constructed for the adaptive repair of the MI microenvironment. The fabricated functionalized chitosan hydrogel (CS/TA@PAs‐Eu) possessed good mechanical stability and ionic conductivity, showing the potential for long‐term adaptation to myocardial tissue pulsation. Also, the CS/TA@PAs‐Eu hydrogel promoted cardiomyocytes (CMs) maturation and functionalization, and effectively improved mitochondrial function, scavenged reactive oxygen species (ROS) as well as promoted angiogenesis. Animal studies indicated that the CS/TA@PAs‐Eu hydrogel can perform adaptive repair of MI to prevent left ventricular (LV) remodeling and restore cardiac function. This study highlights a functionalized hydrogel ECP with good biocompatibility and mechanical robustness for the adaptive repair of MI.