bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative Cleavage and Ring Reconstruction for the Synthesis of Amaryllidaceae Alkaloid Analogues
Authors: Jansa Petr , Císařová Ivana , Matoušová Eliška 
Published: November 2023

AbstractThis study presents the synthesis of analogues of bioactive Amaryllidaceae alkaloids that contain a five‐membered ring C and a quaternary carbon centre. The synthesis was carried out in a divergent manner, starting from a common intermediate, keto aldehyde 1 a. This intermediate was obtained by oxidative cleavage of a carbocyclic ring present in the previously synthesised tetracyclic compounds. Subsequent closure of a new heterocyclic ring B using different methods led to products with structural cores found in naturally occurring alkaloids such as pretazettine, tazettine or macronine. In addition, an analogue of egonine was prepared from the same intermediate. Our approach thus provides access to multiple structural types of potentially bioactive molecules.
An examination and prospect of stabilizing Li metal anode in lithium–sulfur batteries: A review of latest progress
Authors: Song Bingyan , Su Laisuo , Liu Xi , Gao Wanjie , Wang Tao , Ma Yuan , Zhong Yiren , Cheng Xin‐Bing , Zhu Zhi , He Jiarui , Wu Yuping 
Published: November 2023

AbstractThe Li metal anode emerges as a formidable competitor among anode materials for lithium–sulfur (Li‐S) batteries; nevertheless, safety issues pose a significant hurdle in its path toward commercial viability. This review enumerates three historical challenges inherent to the Li metal anode: unavoidable volume expansion, multifunctional solid electrolyte interface formation, and uncontrollable lithium dendrite growth. In particular, when paired with a sulfur cathode, the Li anode presents an additional unique hurdle: the shuttle effect. To address these issues, this article offers a thorough examination of the latest innovations aimed at stabilizing the Li metal anode within Li‐S batteries. We categorize these approaches into five classifications: liquid electrolyte optimization, enhancement of non‐liquid‐state electrolytes, Li metal surface modification, Li anode architecture design, and Li alloy improvement. For several noteworthy results within these categories, we have compiled their electrochemical performance into tables, facilitating direct comparison. This detailed analysis illuminates feasible strategies and suggests directions warranting further exploration for optimizing the capability and safety of Li metal anodes in Li‐S batteries.
Survival, Growth, and Reproduction Responses in a Three-Generation Exposure of the Zebrafish (Danio rerio) to Perfluorooctane Sulfonate
Authors: Gust Kurt A. , Mylroie J. Erik , Kimble Ashley N. , Wilbanks Mitchell S. , Steward Catherine S. C. , Chapman Kacy A. , Jensen Kathleen M. , Kennedy Alan J. , Krupa Paige M. , Waisner Scott A. , Pandelides Zacharias , Garcia-Reyero Natalia , Erickson Russell J. , Ankley Gerald T. , Conder Jason , Moore David W. 
Published: November 2023

Abstract
A prior multigenerational perfluorooctane sulfonic acid (PFOS) exposure investigation in zebrafish reported adverse effects at 0.734 µg/L, among the lowest aquatic effect levels for PFOS reported to date. The present three-generation PFOS exposure quantified survival, growth, reproduction, and vitellogenin (VTG; egg yolk protein) responses in zebrafish, incorporating experimental design and procedural improvements relative to the earlier study. Exposures targeting 0.1, 0.6, 3.2, 20, and 100 µg/L in parental (P) and first filial (F1) generations lasted for 180 days post fertilization (dpf) and the second filial generation (F2) through 16 dpf. Survival decreased significantly in P and F2 generation exposures, but not in F1, at the highest PFOS treatment (100 µg/L nominal, 94–205 µg/L, measured). Significant adverse effects on body weight and length were infrequent, of low magnitude, and occurred predominantly at the highest exposure treatment. Finally, PFOS had no significant effects on P or F1 egg production and survival or whole-body VTG levels in P or F1 male fish. Overall, the predominance and magnitude of adverse PFOS effects at &lt;1 µg/L reported in prior research were largely nonrepeatable in the present study. In contrast, the present study indicated a threshold for ecologically relevant adverse effects in zebrafish at 117 µg/L (SE 8 µg/L, n = 10) for survival and 47 µg/L (SE 11 µg/L, n = 19) for all statistically significant negative effects observed. Environ Toxicol Chem 2024;43:115–131. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
High‐grade intraductal carcinoma of the parotid gland harboring CTNNA1::ALK rearrangement: Changes in genetic status using genetic testing during treatment with an ALK inhibitor
Authors: Watanabe Takane , Honma Yoshitaka , Yonemori Kan , Sunami Kuniko , Yoshimoto Seiichi , Mori Taisuke 
Published: November 2023

AbstractBackgroundSalivary gland carcinomas harboring anaplastic lymphoma kinase (ALK) rearrangements are rare. Here, we present the pathological characteristics, clinical course, and changes in the genetic status of a salivary gland carcinoma harboring a catenin alpha 1 (CTNNA1)::ALK rearrangement during treatment with an ALK tyrosine kinase inhibitor (TKI).MethodsA 59‐year‐old man with a parotid tumor and cervical lymph node metastases underwent total parotidectomy and radical neck dissection. One month after completion of postoperative radiotherapy, the patient experienced multiple recurrences.ResultsSubsequent treatment with the ALK‐TKI alectinib was initially effective against the intraductal carcinoma harboring CTNNA1::ALK rearrangement and TP53 mutation. However, 10 months later the patients' condition deteriorated, and an additional phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA) mutation was detected. The patient ultimately succumbed to multiple organ failure.ConclusionThe clinical course suggested the concurrent emergence of TP53 and PIK3CA mutations and ALK‐TKI drug‐selective growth of non‐ALK rearrangement gene tumor cells.
Prognosis and complete remission rate of diffuse large B‐cell lymphoma patients in standard R‐CHOP with reduction of vincristine: A retrospective study
Authors: Riasi Fatemeh , Ataei Azimi Sajjad , Allahyari Abolghasem , Moeini Nodeh Mohammad , Shakeri Mohammad T. , Kamandi Mostafa 
Published: November 2023

AbstractBackground and AimsThe effect of stopping or reducing the dose of vincristine in diffuse large B‐cell lymphoma (DLBCL) on the outcome and prognosis of the disease is still in doubt. The present study aimed to investigate and compare the prognosis and complete remission of two R‐CHOP treatment regimens with and without vincristine reduction in DLBCL patients.MethodsThis retrospective study was conducted on newly diagnosed DLBCL patients during 2018–2021. The patients were over 18 years of age, had been histologically confirmed by a pathologist, and were under treatment with R‐CHOP regimen. The clinical information of the subjects as well as the number of treatment courses were extracted from their medical records and then compared.ResultsOverall, 269 patients with DLBCL were included in this study, 15.99% of whom (n = 43) had vincristine reduction. There was no significant difference between the studied factors regarding the reduction of vincristine and the complete R‐CHOP regimen (p > 0.05). Besides, no difference was observed in the 1‐year overall survival (OS) and progression‐free survival (PFS) of the patients in the two groups treated with R‐CHOP regimen with and without vincristine reduction (p > 0.05). The complete remission rates of the patients treated with R‐CHOP regimen with and without vincristine (p > 0.05) were not different either. The results of the Cox multivariate regression showed that reducing the dose of vincristine from the R‐CHOP treatment regimen had no relationship with the 1‐year OS and PFS of the DLBCL patients (hazard ratio [HR]OS = 1.59, 95% confidence interval [CI]: 3.67–0.690, HRPFS = 1.67, 95% CI: 0.798–3.82).ConclusionThe results of this study showed that the reduction of vincristine from the R‐CHOP regimen in the DLBCL patients was not likely to make a difference in the 1‐year OS and PFS of the patients. However, further studies are needed on the issue.
A prediction model for the progression from gestational hypertension to pre‐eclampsia complicated with HELLP syndrome
Authors: Li Zhaoqi , Dai Ying , Yun Lin , Guo Wei 
Published: November 2023

AbstractObjectiveHELLP syndrome is a severe complication of hypertensive disorders of pregnancy that can cause multiple organ dysfunction and maternal death in a short period of time. Although HELLP syndrome is more common in patients with pre‐eclampsia (PE), there is currently no effective way to identify high‐risk individuals who may progress from gestational hypertension (GH) to PE complicated with HELLP syndrome. This study aimed to establish and validate a prediction model for PE complicated with HELLP syndrome, providing a basis for early detection and identification of high‐risk individuals in clinical practice.MethodsThis retrospective case–control study collected data on 326 patients with GH and 139 patients with PE complicated with HELLP syndrome from January 2015 to December 2019. An additional 206 patients with GH and 70 patients with PE complicated with HELLP syndrome who were treated from January 2020 to December 2022 were collected for external validation. General and clinical data were collected, and single‐and multiple‐factor logistic regression analyses were used to screen for independent factors affecting PE complicated with HELLP syndrome. The diagnostic performance of different indicators was evaluated using ROC curves. A prediction model for PE complicated with HELLP syndrome was constructed, and its efficacy was verified using ROC curves.ResultsThe results of single‐factor analysis showed that age, SBP, DBP, MAP, hemoglobin, AST, ALT, cholinesterase, alkaline phosphatase, gamma‐glutamyl transferase, total protein, total bilirubin, direct bilirubin, indirect bilirubin, BUN, UA, creatinine, APTT, international normalized ratio of prothrombin, D‐dimer, fibrinogen, fibrinogen degradation products, Ca, and aspartate‐aminotransferase to platelet ratio index (APRI) were factors influencing PE with HELLP syndrome. The results of multiple‐factor logistic regression analysis showed that MAP, APRI, CHE, FDP, and Ca were independent factors affecting PE complicated with HELLP syndrome. Based on these results, a prediction model was established, with Y = 9.861 + 2.998APRI + 0.055MAP + 0.014FDP − 0.005CHE − 7.452*Ca.ConclusionsThe predictive model for PE complicated with HELLP syndrome includes APRI, MAP, FDP, CHE, and Ca. This model can be used as a quantitative tool for predicting and evaluating the development of GH into PE complicated with HELLP syndrome.
Optical clearing of human skin: Molecular modeling and in vivo OCT study
Authors: Berezin K. V. , Grabarchuk E. V. , Lichter A. M. , Dvoretski K. N. , Tuchin V. V. 
Published: November 2023

AbstractThe results of in vivo immersion optical clearing of human skin under the action of two different optical clearing agents (OCAs), such as an aqueous sucrose solution and a radiographic contrast agent Omnipaque™ 300 (iohexol), were obtained with the use of optical coherence tomography (OCT) method. The rate of reduction of light scattering coefficient, obtained through an averaged A‐scan of the OCT image in the region of dermis within the depths from 350 to 700 μm, were determined to evaluate the efficiency of optical clearing (EOC). The correlations between the EOC and the energy of intermolecular interaction of OCAs with a fragment of collagen peptide have been established as a result of molecular modeling by quantum chemistry methods HF/STO3G/DFT/B3LYP/6—311G(d) of a number of OCAs (glycerol, iohexol, sucrose, ribose, fructose, glucose) with mimetic peptide of collagen (GPH)3.
Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila
Authors: Miao Hongyu , Wei Yanan , Lee Seung Gee , Wu Zekun , Kaur Jasdeep , Kim Woo Jae 
Published: November 2023

AbstractSimilar to the human brain, Drosophila glia may well be divided into several subtypes that each carries out specific functions. Glial GPCRs play key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. A recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells disrupts Drosophila development, while knocking down other LGR family members in glia has no impact. Adult‐specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.
Mechanisms for Affect Communication from Dance: A Mixed Methods Study
Authors: Stutesman Megan G. , Goldstein Thalia R. 
Published: November 2023

ABSTRACTDance is a multifaceted creative act that has been used to communicate emotions throughout human evolution. Despite this history, there has been no empirical exploration of components of dance that allow it to communicate emotion. We address this with a mixed methods study in which a quantitative study with dance viewers builds upon qualitative findings with dance artists. Qualitative analysis revealed proposed components of dance responsible for emotion communication are narrative content, social interaction, emotion portrayal intent, and textural quality of movement. These elements were then manipulated using dance video stimuli to quantitatively test viewers' emotion perception accuracy. Results revealed emotion portrayal intent (i.e., expression intent in dance creation) is an important factor for viewers to accurately perceive emotion, regardless of narrative content. While prior studies have focused on the perceiver's role in emotion perception from dance, this is the first study to demonstrate emotions are perceived from dance based on intent during dance creation. Findings highlight the nuanced structure of emotion communication in dance, for which we pose a theoretical framework. Together, dance holds possibilities for studying distinct mechanisms for creative communication that may be important for the study of generalized affect communication outside of creative arts contexts.
Differentiation through E‐nose and GC‐FID data modeling of rosé sparkling wines elaborated via traditional and Charmat methods
Authors: Muñoz‐Castells Raquel , Modesti Margherita , Moreno‐García Jaime , Rodríguez‐Moreno María , Catini Alexandro , Capuano Rosamaria , Di Natale Corrado , Bellincontro Andrea , Moreno Juan 
Published: November 2023

AbstractBACKGROUNDThe growing demand for rosé sparkling wine has led to an increase in its production. Traditional or Charmat wine‐making influence the aromatic profiles in wine. An analysis such as gas chromatography makes an accurate assessment of wines based on volatile detection but is resource intensive. On the other hand, the electronic nose (E‐nose) has emerged as a versatile tool, offering rapid, cost‐effective discrimination of wines, and contributing insights into quality and production processes because of its aptitude to perform a global aromatic pattern evaluation. In the present study, rosé sparkling wines were produced using both methods and major volatile compounds and polyols were measured. Wines were tested by E‐nose and predictive modelling was performed to distinguish them.RESULTSVolatile profiles showed differences between Charmat and traditional methods, especially at 5 months of aging. A partial least square discriminant analysis (PLS‐DA) was carried out on E‐nose detections, obtaining a model that describes 94% of the variability, separating samples in different clusters and correctly identifying different classes. The differences derived from PLS‐DA clustering agree with the results obtained by gas‐chromatography. Moreover, a principal components regression model was built to verify the ability of the E‐nose to non‐destructively predict the amount of different volatiles analyzed.CONCLUSIONProduction methods of Rosé sparkling wine affect the final wine aroma profiles as a result of the differences in terms of volatiles. The PLS‐DA of the data obtained with E‐nose reveals that distinguishing between Charmat and traditional methods is possible. Moreover, predictive models using gas chromatography‐flame ionization detection analysis and E‐nose highlight the possibility of fast and efficient prediction of volatiles from the E‐nose. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Structural and rheological characterization of water‐soluble and alkaline‐soluble fibers from hulless barley
Authors: Xu Yuting , Liu Xiaoning , Ma Mengting , Wang Mingming , Hua Weifeng , Yao Tianming , Sui Zhongquan 
Published: November 2023

AbstractBACKGROUNDHighland hulless barley has garnered attention as a promising economic product and a potential healthy food ingredient. The present study aimed to comprehensively investigate the molecular structure of extractable fibers obtained from a specific highland hulless barley. Water‐soluble fiber (WSF) and alkaline‐soluble fiber (ASF) were extracted using enzymatic digestion and an alkaline method, respectively. The purified fibers underwent a thorough investigation for their structural characterization.RESULTSThe monosaccharide composition revealed that WSF primarily consisted of glucose (91.7%), whereas ASF was composed of arabinose (54.5%) and xylose (45.5%), indicating the presence of an arabinoxylan molecule with an A/X ratio of 1.2. The refined structural information was further confirmed through methylation, 1H NMR and Fourier‐transform infrared spectroscopy analyses. WSF fiber exclusively exhibited α‐anomeric patterns, suggesting it was an α‐glucan. It has a low molecular weight of 5 kDa, as determined by gel permeation chromatography. Conversely, ASF was identified as a heavily branched arabinoxylan with 41.55% of ‘→2,3,4)‐Xylp‐(1→’ linkages. ASF and WSF exhibited notable differences in their morphology, water absorption capabilities and rheological properties.CONCLUSIONBased on these findings, molecular models of WSF and ASF were proposed. The deep characterization of these fiber structures provides valuable insights into their physicochemical and functional properties, thereby unlocking their potential applications in the food industry. © 2023 Society of Chemical Industry.
Enantioselective Molecularly Imprinted Polymer for Tyrosine, Tryptophan, and Phenylalanine, and the Possibility of the Crop‐Circle‐Like Imprinting
Authors: Cho Min Gi , Hyeong Seonghoon , Park Kyung Kgi , Chough Sung Hyo 
Published: November 2023

AbstractMolecularly imprinted polymer (L‐MIP) for L‐tyrosine (L‐Tyr) is prepared by the complexation between quaternized poly(4‐vinylpyridine/divinylbenzene) (QVP) and poly(acrylamide‐co‐acrylic acid) (PAmA) in alkaline solution. The L‐MIP shows higher enantioselectivity for L‐isomers of tyrosine, together with tryptophan (Trp) and phenylalanine (Phe) compared to the D‐isomers of them. The sorption isotherms of the three D‐enantiomers are converged to one isotherm. It can reflect that the sorption of D‐enantiomers can be relied mainly on the common segment, ‐CH2‐CH(NH2)‐COOH, neglecting any effect of bulkier aromatic groups. The imprinted common segment can be opened on the surface of MIP from the D‐enantiomers. For the L‐enantiomers, the sorption discrepancies are depended on the size of the aromatic group implying that the phenolic moiety of L‐Tyr can be also opened. Thus, the imprinted sites are proposed to be opened on the surface of L‐MIP similar to the crop‐circle‐like. The enantioselectivity factors, αef = QL/QD, for Tyr, Trp, and Phe are 1.52, 1.30, and 1.52 for L‐ to D‐isomers, respectively. And the uptake differences between D‐ and L‐enantiomers of Tyr, Trp, and Phe are 31.8, 20.7, and 29 mg per 1 g MIP, respectively.
Science and opinion in decision making: A case study of the food security collapse in Sri Lanka
Authors: Wijerathna‐Yapa Akila , Henry Robert J. , Dunn Matt , Beveridge Christine A. 
Published: November 2023

AbstractMaking decisions related to security, whether at the community, national, or regional level, is a highly intricate task. This requires a multi‐criteria decision‐making approach that incorporates inputs from various perspectives, including those of science, culture, economics, sustainability, and climate change. In order to make successful decisions, it is imperative to compare alternatives and rank the consequences and relative impacts associated with each option. Such comparisons and rankings require a careful balance of evidence‐based scientific data and diverse opinions. The recent scenario of the food security collapse in Sri Lanka provides a poignant reminder of the importance of this decision‐making process and the consequences of unacknowledged or unidentified misinformation. Sri Lanka responded to an unexplained health condition and a desire to enter a new sales market by swiftly transitioning to organic farming. However, this abrupt change led to the rapid collapse of Sri Lanka's food supply, a significant decline in GDP, and hardships for both rural and urban communities. While the government eventually reversed its policy, Sri Lanka faced challenges in recovery. It is evident that disinformation and misinformation played a role in this unfortunate situation. This paper offers an in‐depth exploration of the events, underlining the necessity to distinguish between disinformation and misinformation in policy development.