bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of UA levels with the risk of severe CED in LVO-AIS patients after mechanical thrombectomy
Authors: Abuduaini Mayila , Long Yuming , Li Gang , Zhu Tianrui , Wu Yuefei , Wang Qi , Xiong Xinli , Zhang Yue 
Published: November 2023

Abstract
Background
Severe cerebral edema (CED) increases the poor prognosis and mortality rate of acute ischemic stroke (AIS) and reduces the benefit of intravascular therapy. Uric acid (UA) has been reported to possess a potential protective effect against AIS. The aim of our study was to explore the association between UA and severe CED after intravascular therapy.
Method
We conducted a retrospective cohort study of patients with large vascular occlusion acute ischemic stroke (LVO-AIS) who underwent endovascular thrombectomy (EVT) and had an mTICI grade of 2b-3 after EVT. A total of 272 LVO-AIS patients who accepted EVT were enrolled in the final study. All patients were divided into two groups according to the degree of CED: severe CED (N = 97) and mild CED (N = 175).UA levels at admission and imaging data at 24–48 h were collected. Baseline characteristics were compared using the chi-squared test, analysis of variance, or Mann-Whitney U-test. To examine the relationship between UA levels and CED, severe CED was estimated by modelling UA as a categorical variable using conditional logistic regression. Stratified analyses based on important covariates were conducted to explore possible protective factors.
Result
The UA levels were inversely associated with severe CED after adjustment for potential confounders (adjusted odds ratio [aOR], 1.00; 95% confidence interval [CI]: 0.99-1.00; p = 0.025). Participants with UA ≥ 360 µmol/L had a significantly lower risk of severe CED than participants with UA < 360 µmol/L when UA levels were categorized by clinical cut-off point (aOR, 0.48; 95% CI, 0.24–0.96; p = 0.039). The inverse association between UA and severe CED was significantly stronger in participants with lower blood glucose levels (< 7.5 mmol/L) compared with those higher blood glucose levels (≥ 7.5 mmol/L) (aOR, 0.21;95% CI, 0.07-0.62l; p for interaction = 0.021).
Conclusion
UA may be a potential protective factor against severe CED in LVO-AIS patients receiving EVT. Further more, the protective effect may be enhanced by lower blood glucose levels compared to higher blood glucose levels.
Electrothermal Conversion of Methane to Methanol at Room-Temperature with Phosphotungstic Acid
Authors: Yan Ning , Chang Jinquan , Wang Sikai , Hülsey Max , Lou Shi Nee , Ma Xinbin 
Published: November 2023

Abstract
Traditional methods for anerobic oxidation of methane to methanol frequently require the use of noble metal catalysts or flammable H2-O2 mixtures. While electrochemical methods enhance safety and may avoid the use of noble metals, these processes suffer from low yields due to limited current density and/or low selectivity. Here, we design an electrothermal process to conduct aerobic oxidation of methane to methanol at room temperature using phosphotungstic acid (PTA) as a redox mediator. When electrochemically reduced, PTA activates methane with O2 to produce methanol selectively. The optimum productivity reaches 29.45 μmol gPTA-1 h-1 with approximately 10% overall Faradic efficiency. Under continuous operation, we achieved 19.90 μmol gPTA-1 h-1 catalytic activity, over 88.6% methanol selectivity, and 10 hours durability. This approach leverages reduced PTA to initiate thermal catalysis in solution phase, addressing slow methane oxidation kinetics and preventing overoxidations on electrode surfaces. The current density towards methanol production increased over 40 times compared with direct electrochemical processes. The in-situ generated hydroxyl radical, from the reaction of reduced PTA and oxygen, plays an important role in the selective methane conversion. This study demonstrates reduced polyoxotungstate as a viable platform to integrate thermo- and electrochemical methane oxidation at ambient conditions.
Unlocking NUE Potential via PASP-Ca Synergist: Insights into physio-biochemical, enzymatic and molecular analyses of contrasting potato genotypes in aeroponics
Authors: nazeer hafsa , Wang Kexiu , Ma Haiyan , Tang Mingxia , saba Tahseen , Hu Tingyuan , jahandad Ambreen , Fang Xiaoting , Zhang Kaiqin , ansar Muhammad , He Wei , Zheng Shun-lin 
Published: November 2023

Abstract
Background
Polyaspartic Acid-Calcium (PASP-Ca) is a versatile and eco-friendly amino acid complex, primarily recognized for bolstering nitrogen use efficiency and crop productivity. However, the core significance of this complex remains enigmatic in potato crop. We hypothesized that simultaneous application of PASP-Ca with potato genotypes characterized by substantial root systems and high genetic potentials for nitrogen-use efficiency (NUE) would best address this knowledge gap.
Methods
The synergistic effect of various PASP-Ca treatments on morphophysiological, N-related, and enzymatic parameters coupled with their transcript levels (shoot and root) in four potato genotypes having contrasting NUEs under low and high N supplies in aeroponics.
Results
PASP-Ca markedly boosted plant growth, yield components, and photosynthetic efficiency, with pronounced effects observed in nitrogen-efficient genotypes, especially Qingshu-9, emphasizing the importance of genotype selection in optimizing nitrogen utilization. Moreover, PASP-Ca treatments, particulartly LN-P100 significantly enhances root system architecture (RSA), contributing to expanded root dimensions and improved nutrient acquisition capacity, especially under nitrogen-deficient conditions. Carbohydrate metabolism in potato tubers benefits from PASP-Ca treatment, leading to increased starch content, thereby impacting tuber quality. Among the N-assimilating enzymes, a large genotypic variation was observed for glutamine synthetase (GS), which may be considered a potential trait for improving NUE. Molecular analysis further elucidated the underlying mechanisms, demonstrating the upregulation of essential genes involved in nitrogen metabolism.
Conclusions
The potential efficacy of PASP-Ca synergist as a novel accelerant for enhancing potato crop growth, biomass production, and nitrogen utilization efficiency, all coalescing seamlessly with the ethos of sustainable agricultural practices.
The intrinsic problems in EQ damage prognosis: the experience from a systematic evaluation of L’Aquila databases and different Levels of Data Availability.
Authors: Lamadrid Lissethe Fernanda Gonzalez , Schwarz Jochen , Maiwald Holger 
Published: November 2023

Abstract

Within the European TURNkey project, a knowledge-based exposure-modelling framework was developed enabling the consideration of different levels of investigation and data availability. In particular, the proposed framework recognizes various levels and origins of uncertainties as well as the completeness of a building stock catalogue. Despite enormous efforts, the main question remains unanswered: How reliable could be the developed tools and instruments if they are not tested and confirmed by real events. The L’Aquila 2009 earthquake has been subject of several analysis strategies to enrich the knowledge of earthquake engineering. In the present, the information provided by Italian Observed Damage Database is analyzed, specifically the data related to the L’Aquila 2009 seismic sequence, within the delimited area of the historical center of the city. A second source where the European Macroseismic Scale was used as reference is hereby integrated to the study and results are compared. A methodology is implemented for a systematic evaluation of database, taking as basis the EMS-98. From the data analysis a proposal is given to define a comparable EMS-98 building typology and for the assignments of vulnerability classes considering an optimistic, pessimist and most likely criteria. The reliability of the sample is then explored taking as basis the Knowledge-based exposure modelling framework established by the TURNkey Project, and the parameter is evaluated through an empirical inspection of frontal (lateral) views available in Google Street View (2022). Images before and after the event are collected and compared with the available data. Intrinsic encountered problems are then enlisted and discussed, with respect to the use of the database, the correlation of the information and the postprocessing needed to use the data in damage prognosis. This paper intends to demonstrate how reliable datasets for the building stock including structural types and corresponding vulnerability classes can be elaborated. Not at least, the exposure modelling has to transform the available data into a descriptive form that can be linked with the Fragility and/or Vulnerability Functions, directly with the expectation that these assignments are the best suited or representative ones. The data layers provided by the study enable the test and train the applicability of the exposure modelling techniques for the selected event and target region.
Therapeutic potential of Cordyceps militaris mushroom against SARS-CoV-2 : Virtual screening against Mpro and in vitro validation
Authors: Baig Mohammad Hassan , Dong Jae-June , Lee Dae Hee , Kim Young Guk , Lee Mi Kyeong , Cho Jae-Yong , Turk Ayman , Vishwakarma Preeti 
Published: November 2023

Abstract
Pathogenic coronavirus, including COVID-19, threatens human health, and there are strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects. Therefore, the inhibitory potentials of constituents of C. militaris against COVID-19 were analyzed using various virtual screening analyses. Among ten constituents of C. militaris, cordycepin, the major component, and 3´-deoxyuridine and 2´-O-methyl-adenosine showed strong binding affinity to Mpro, a potential target for COVID-19 therapeutics. Considering the structure activity relationship, nucleosides having deoxyribose and methoxyribose moiety are important for the affinity to Mpro. Cordycepin is also bound to Mpro mutants, and the binding mechanisms between cordycepin and Mpro were further demonstrated by MD simulation, RMSA, and MM/PBSA analysis. Principal component analysis also confirmed the conformational change of Mpro by cordycepin, which inhibits the function of Mpro. In vitro, the efficacy of cordycepin was measured using Vero cells infected with SARS-CoV-2, which showed excellent inhibition with an IC50 value of 29 μM. Conclusively, the constituents of C. militaris are expected to inhibit SARS-CoV-2 replication through binding to Mpro. Therefore, C. militaris can be an important therapeutic for coronavirus through the synergistic effect of its constituents.
Towards elimination of HCV infection in undocumented migrants and low-income refugees: a prospective intervention study in Italy
Authors: Coppola Nicola , Alessio Loredana , De Pascalis Stefania , Macera Margherita , Caprio Giovanni Di , Messina Vincenzo , Onorato Lorenzo , Minichini Carmine , Stanzione Maria , Stornaiuolo Gianfranca , Starace Mario , Monari Caterina , Calò Federica , Sagnelli Caterina , Pisaturo Mariantonietta 
Published: November 2023

Abstract
Background: Migrants, mainly undocumented and low-income refugees, are at high risk of HCV infection, but are a difficult-to-reach and to-treat population. The aim of the study was to identify a elimination model for HCV infection in these undocumented migrants and low-income refugees living southern Italy.
Methods: a prospective, multicenter, collaborative study based on a four-phase-program (educational counseling, screening, linkage-to-care and treatment) was designed. After educational counseling on parenteral infections, anonymous HCV screening was offered to all undocumented imigrants and low-income refugees observed at one of the 1st level clinical centers. The HCV-RNA-positive subjects were referred to one of the 3rd level units of Infectious Diseases (ID) and treated with a 12-week course of sofosbuvir-velpatasvir and observed for 12 weeks after the end of DAA treatment.
Results: Of the 3,501 migrants observed in the study period, 3,417 (97.6%) agreed to be screened; 185 (4.7%) were anti-HCV-positive and, of these, 53 (28.6%) were HCV-RNA-positive. Of these 53 subjects, 48 (90.5%) were referred to an ID unit and started DAA treatment. Of these 48 subjects, 47 (97.9%) showed a sustained virological response and one dropped-out in follow-up after DAA treatment. No subject had any adverse event.
Conclusions: This model seems effective to eliminate HCV infection in a difficult-to-reach and to-treat population, such as undocumented migrants and low-income refugees
Influencing factors and burden of hospital-acquired infections among cancer patients
Authors: Huang Lihua , Ning Huacheng , Liu Xin-Chen , Wang Yongjie , Liu Qing , Li Huan 
Published: November 2023

Abstract
Background
To explore the influencing factors and evaluate the economic loss of hospital acquired infections (HAIs) in cancer patients so as to provide evidence for reasonable prevention policies and measures.
Methods
Patients who were discharged for the first time from Sun Yat-sen University Cancer Center between Jan 1 and Dec 31, 2022 were recruited. Data were obtained from the medical record system and the nosocomial infection surveillance system. Logistic regression model was adopted to analyze the influencing factors of HAIs. By using 1:1 case-control matching and Wilcoxon signed rank test, economic loss and length of hospital stay (LOS) caused by HAIs were estimated.
Results
A total of 45030 cancer patients were enrolled in this study, of which 457 suffered HAIs. Logistic regression analysis showed that older age, longer retention days of deep vein catheter, longer indwelling days of urinary catheter, diabetes mellitus, male, surgical operation, and myelosuppression were all independent risk factors for HAIs (odds ratios ranges from 1.01 to 10.68). The analysis of 256 matched pairs presented that the total hospitalization expenditure and self-paid expenditure of the HAI group (114.79, 51.56 thousand-yuan, respectively) were significantly higher than those of the non-HAI group (77.15, 34.68 thousand-yuan, respectively). Compared with non-HAI group, the LOS in HAI group was significantly longer by 8 days.
Conclusions
HAIs lead to the increase of direct economic burden and LOS in cancer patients. Cancer patients who are male, older age, administrated with invasive operations, with diabetes mellitus and myelosuppression are more susceptible to HAIs.
Measuring Eco-Emotions - A German version of questionnaires on eco-guilt, ecological grief, and eco-anxiety
Authors: Zeier Peter , Wessa Michèle 
Published: November 2023

Abstract
In the face of climate change, people experience a variety of emotions, e.g., guilt, grief, and anxiety. Although these emotions are generally considered unpleasant, they may play a key role in dealing with climate change by motivating pro-environmental behavior. In 2022, Ágoston et al. introduced three questionnaires to assess eco-guilt (EGuiQ-11), ecological grief (EGriQ-6), and eco-anxiety (EAQ-22). We translated and validated these questionnaires in a large German sample (N = 871). More specifically, the current study not only intended to replicate the factor structures of all three questionnaires, but also expand previous findings by investigating associations of eco-emotions with pro-environmental behavior intentions, climate policy support, climate anxiety, and psychological distress. Confirmatory factor analyses indicated the one-factor structure of the EGuiQ-11 and the two factors habitual ecological worry and negative consequences of eco-anxiety of the EAQ-22. The one-factor solution of the EGriQ-6, however, did not yield satisfactory model fit. Consequently, we suggest an item reduction of the EGriQ-6 to adequately assess ecological grief in German-speaking populations. All eco-emotions were positively associated with pro-environmental behavior intentions and environmental policy support, but also with levels of climate anxiety as well as general anxiety and depression. All in all, the translated questionnaires seem suitable measurements of eco-guilt, ecological grief, and eco-anxiety that capture the adaptive and maladaptive aspects of these emotions.
Osteoporosis and Cognitive impairment: a bibliometrics study and visualization analysis via CiteSpace
Authors: Jiang Jing , Xu Jingjuan , Wang Wenyan , Chen Xiaohang , wu Zhishui 
Published: November 2023

Abstract
The purpose of this study is to evaluate the research hotspots and trends in comorbidity studies of osteoporosis and cognitive impairment through literature visualization analysis and provide valuable insights for further applications and research in this field. Methods: Using the Web of Science database, relevant literature on co-morbidity studies of osteoporosis and cognitive impairment published until October 20, 2023, was retrieved. CiteSpace was employed to analyze the publication trends, countries, institutions, author collaborations, co-occurring keywords, and burst keywords in this research area. Results: A total of 917 relevant publications on co-morbidity studies of osteoporosis and cognitive impairment were included in the analysis. The research in this area is primarily concentrated in countries such as the United States, Italy, China, the United Kingdom, and Australia. High-impact authors include Julie A. Pasco and Sophia X. Sui. Cluster analysis revealed key topics such as hip fractures, bone density, cognitive impairment, breast cancer, and randomized trials. The top three burst keywords, ranked by burst strength, were quality of life, postmenopausal women, and hormone replacement therapy. Conclusion: The number of co-morbidity studies on osteoporosis and cognitive impairment has been steadily increasing in recent years. However, based on the results from CiteSpace, we recommend more active collaboration among countries, institutions, and authors to facilitate clinical and basic research. Current research focuses on exploring the correlation and epidemiological characteristics of osteoporosis and cognitive impairment. Developing simple, reliable early screening methods and effective early interventions may become the research hotspots for the management of co-morbidity between osteoporosis and cognitive impairment.
Environmental Effect on Optical Properties of Bromothymol Blue: Experimental and Simulation
Authors: Shoraka Maryam , Roknabadi Mahmood Rezaee , Shahtahmassebi Nasser , Sharifi Soheil 
Published: November 2023

Abstract

Effects of environmental properties on linear and nonlinear response of Bromothymol blue (BTB) were studied. The role of optical band gap and dielectric constant, as well as thermal conductivity on optical properties of BTB molecule and cetyltrimethylammonium bromide (CTAB) with BTB complex were discussed using Z-scan instrument with 532 nm wavelength and 80 mW power, spectrophotometer and FT-IR spectra. The orders of nonlinear absorption coefficient, β, and nonlinear refractive index, n2, of BTB were obtained 10–12 cm2/W and 10− 7 cm/W, respectively. The reverse saturable absorption is the main factors in the appearance of β. It was observed, enhancement up to 5 time in dielectric constant of environment cause reduction of about 6 time in nonlinear absorption and about 2 time in nonlinear refraction coefficient of solution. Moreover, the complex of CTAB can reduce optical band gap of BTB by 0.7eV. Results of DFT calculations have performed, via B3LYP method and 6-311G(d,p) basis, show enhancement of dipole moment of BTB with increase of dielectric constant of environment.
Breastfeeding performance of late preterm newborns with hyperbilirubinemia undergoing phototherapy: Controlled Cross-Sectional Study
Authors: Neves Ana Paula Sabino de Medeiros , Yamamoto Raquel Coube de Carvalho , Camargo Juliana Dantas de Araújo Santos , Junior Hipólito Virgilio Magalhães 
Published: November 2023

Abstract
Background: Prematurity is a risk factor for eating disorders. However, late preterm newborns are generally cared for in a rooming-in unit, with no different management from term newborns. Hyperbilirubinemia is considered physiological, but can be potentially neurotoxic at high levels. Phototherapy is the most widely used treatment, but it can lead to adverse events, such as circadian rhythm changes. Preterm infants are at greater risk of neurotoxicity due to hyperbilirubinemia and feeding difficulties are a risk factor for increased serum bilirubin levels. In view of this, it is necessary to evaluate the breastfeeding performance of late preterm infants in order to provide data that will enable appropriate management in the face of possible difficulties and guarantee that preterm infants undergoing phototherapy will have an effective feed and adequate intake.
Methods: Controlled cross-sectional study. Conducted in a public maternity hospital, the sample was based on convenience and consisted of 60 mother/late preterm newborn dyads, assisted in the Joint Lodging, divided into two groups. One group comprised of 30 mother/newborn dyads in which the newborns had hyperbilirubinemia that required phototherapy (case group) and another group with 30 dyads in which the newborns did not require phototherapy (control group). Data characterizing the sample was obtained through anamnesis and medical/hospital records. Breastfeeding performance was assessed using the Breastfeeding Observation Form proposed by UNICEF. The analyses were carried out using Jamovi (version 2.4.1). The significance level of 5% was adopted for all analyses. The study was approved by the Research Ethics Committee. All participants/guardians signed the Free and Informed Registration Form.
Results: Newborns in the case group had a higher occurrence of "fair" and "poor" scores in all the protocol categories.
Conclusion: The study concluded that late preterm newborns undergoing phototherapy have more difficulties in breastfeeding compared to late preterm newborns who do not require the treatment, and therefore need careful and individualized attention in the management of breastfeeding.