bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional two-sample Mendelian randomization analysis reveals a causal correlations of inflammatory cytokines on diabetic nephropathy risk
Authors: Song Siyuan , Yu Jiangyi 
Published: November 2023

Abstract

Objective:
The causal correlations of inflammatory cytokines on diabetic nephropathy risk was explored by Bidirectional two-sample Mendelian randomization analysis.
Method:
In this study, the data of diabetic nephropathy (DN) was extracted from the IEU OpenGWAS Project database, and the data on inflammatory cytokines was obtained from GWAS summary statistics from catalog database. The inverse variance weighted (IVW) is used as the main analysis method, and MR-Egger regression, weighted mode, and weighted median (WM) are used as supplementary methods to analyze the causal correlations of inflammatory cytokines on diabetic nephropathy risk. Cochran Q test and MR-Egger regression intercept are used for sensitivity analysis, and the P value is used as the index of results.
Result:
A total of 4 SNPs associated with inflammatory cytokines were screened as instrumental variables, IVW results showed a causal relationship between tumor necrosis factor ligand superfamily member 14 levels and TNF-related activation-induced cytokine levels and DN with a positive correlation, while Interleukin-1-alpha levels and Transforming growth factor-alpha levels had a causal relationship with DN with a negative correlation. The results of the ME-Egger intercept test were not multiplicative (P > 0.05), indicating that Mendelian randomization was a valid method for causal inference in this study. The results of reverse MR analysis showed that there was no causal relationship between DN and the increased risk of positively identified inflammatory cytokines.
Conclusion:
Tumor necrosis factor ligand superfamily member 14 levels and TNF-related activation-induced cytokine levels are independent risk factors for DN, while Interleukin-1-alpha levels and Transforming growth factor-alpha levels are independent protective factors for DN.
One equivalent mining height model for predicting the compression-consolidation-creep-diagenesis of compacted gangue backfill body——A case study on double wide-strip mining with gangue backfill
Authors: Xu Lei , Wang Siyu , Elmo Davide , Ding Shuxue , Zhu Hengzhong , Li Wenfeng , Chen Wen 
Published: November 2023

Abstract
Taking the double wide-strip mine gangue backfilling work face of 1101 and 1102 in the Tingnan Coal Mine as the background, this study utilizes theoretical analysis, numerical simulation, laboratory experiments, and engineering practices to investigate the complete process of compression-consolidation-creep-diagenesis of the compacted gangue backfill body, the equivalent mining height model, and the surface subsidence characteristics. The results: The maximum control roof distance in the gangue backfilling work face=Tip-to-face distance + Cutting depth + Roof beam length + Post-support gap. The advance subsidence amount of roof is equal to the maximum control roof distance multiplied by the sine value of the roof inclination angle. The height of available backfill space behind the support is equal to the mining height minus the roof advance subsidence, the unfilled height under roof, and the amount of floor heave behind the support. The compacted gangue body undergoes four stages of compression-consolidation-creep- diagenesis within the available filling height, with their respective compressibility rates as follows: skeleton adjustment stage (7.42%), slow compression stage (12.81%), consolidation settlement stage (13.15%), and creep diagenesis stage (25.53%). The equivalent mining heights corresponding to the four stages are 0.94m, 1.10m, 1.11m, and 1.48m, respectively. By comparing the predictions from probability integral method, numerical simulations, and subsidence observations, it is evident that the surface subsidence curves of the 1101 and 1102 working faces, along the strike main section, exhibit a "bowl" shape, with a gentle slope in the first two stages and a steep slope in the latter two stages. ht=Lmax×sinθ The subsidence curves of the 1101 and 1102 working faces, along the dip main section, show a "bowl" shape in the first two stages, and a "W" shape in the latter two stages.
Secured Healthcare Data Sharing Through Wireless Networks for Mobile Computing Using Trust-Bat-Adaptive Homomorphic Crypto Routing Protocol
Authors: Aljohani Abeer A. , Tripathi Rajendra Kumar , Bhardwaj Rajat , Kaushal Rajesh Kumar , Kumar Naveen , Gupta Shashi Kant , Hamato Gemechu Geda 
Published: November 2023

Abstract
The Wireless Sensor Network's (WSN's) sensor nodes commonly communicate via mobiles, which have been widely regarded as the most prevalent and perhaps most important communication technology. Due to their self-configuration, ease of handling, and adaptability, WSNs have become more popular in mobile computing. The WSN is set up with extra nodes to transport data. As a result of their short memory, poor throughput, restricted capacity, and other limitations, sensor networks become notoriously difficult to secure. WSN has been grappling with how to maintain network security in mobile computing while using as little power as possible in current history. So, we present a novel trust-bat-adaptive homomorphic crypto routing protocol (TBAHCRP) to overcome these difficulties. Initially, we gather healthcare datasets from the medical server and deploy a 5G (fifth-generation) network to transfer these datasets from sending node to receiving node. The encryption and decryption are performed by employing the proposed technique and it also performs clustering and routing functionalities. A multi-gradient spider monkey optimization (MG-SMO) approach is applied to optimize the received data for mobile applications. Finally, performance metrics like security level, memory usage, energy efficiency, and energy consumption of the proposed technique are examined and compared with other classical techniques to prove our work with the greatest efficiency. These metrics are depicted in graphical form by using the MATLAB tool.
Prevalence and Risk Factors of Helicobacter pylori Infection in children in Fuzhou, a High-Incidence Area for Gastric Cancer in Southeastern China
Authors: Chen Youtao , Pan Xiaoting , Wang Yanyan , Lin Longzhen , Chen Xiaoyan , Chen Yan , Ye Hong 
Published: November 2023

Abstract
Background
The burden of Helicobacter pylori infection remains high. Comprehensive data on the prevalence of H. pylori infection and associated risk factors in children remain scarce. The aim of this study was to investigate the prevalence of H. pylori infection and the risk factors for infection in a randomly selected population of children from a city in southeastern China.
Methods
A cross-sectional, randomized study of prevalence and risk factors was carried out among the children living in an urban community in southeastern China. A stratified random sampling method was first used to identify appropriate subjects. H. pylori infection was determined using the 13C-urea breath test. Risk factors were assessed using a structured interview schedule. Demographic information was collected on a standardized basis, and participants were given a questionnaire about their lifestyle choices, level of parental education and household size.
Results
In this survey, the sample population consisted of 338 children from 6–13 years old. The overall prevalence of H. pylori was 22.2% (75/338). The infection was most common for those aged 10–11 years. In this group 34.7% (33/95) of all children were positive for H. pylori, while in children aged 6–7 years 8.3% (4/48) were positive. In the multivariate logistic regression analysis, eat dessert or fried foods frequently and larger household size (≥ 4) were risk factors for H. pylori infection, higher family year income and frequency of household indoor cleaning were protective factors for H. pylori infection.
Conclusions
This study shows that children living in low socioeconomic status and poor sanitation become infected with H. pylori at an early age. The infection increased with age, eat dessert or fried foods frequently and domestic overcrowding. Further longitudinal studies must delve into the possible modes of transmission of this pathogen among young children.
Colistin Enhances Antimicrobial Activity against colistin-resistant Klebsiella pneumoniae by combined with the Chinese herbal crocin-1
Authors: Du Xin , Zhou Huijing , Wang Yue , Liu Yan , Huang Yali , Shi Shiyi , Xu Mengxin , Zhou Tieli , Zhou Beibei 
Published: November 2023

Abstract
Background Colistin (COL) is one of the last-line antibiotics of defense against multidrug-resistant (MDR) gram-negative bacteria However, colistin-resistant (Col-R) Klebsiella pneumoniae (K. pneumoniae) is increasing, which limits the clinical use of COL. Saffron is a traditional Chinese medicine with the effects of promoting blood circulation and removing blood stasis, relieving depression and calming the nerves, protecting the liver and promoting the gallbladder. Croin-1(CR) is an active ingredient extracted from saffron. In this study, we studied the antibacterial effects of CR and COL on Col-R K. pneumonia in vivo and in vitro.
Methods The checkerboard method and time-killing curve confirmed the synergistic antibacterial effect of CR combined with COL on Col-R K. pneumonia. The synergistic anti-biofilm and antibacterial activity were detected by crystal violet staining, scanning electron microscopy (SEM), and living cell fluorescent staining. The safety was assessed by the red blood cells (RBCs) hemolysis test, larval survival rates, and cytotoxicity test. The mice thigh infection model was established for in vivoexperiment. We determined the outer membrane permeability by measuring the uptake of fluorescent dye N-phenyl-1-naphthylamine(NPN) and propidium iodide (PI) staining. We further detected bacterial reactive oxygen species (ROS) production.
ResultsThe Results showed that compared with a single drug, the combination partially destroyed bacterial cells and inhibited the formation of bacterial biofilms. The CR/COL combination could decrease the number of bacteria after 24 h of therapy in the mouse thigh infection model. The CR/COL combination synergistically potentiated the antibacterial activity by accelerating the damage and permeability of the bacterial outer membrane. Erythrocytes hemolysis test showed that the hemolysis ability of CR was negligible. Therefore, CR has certain security.
Conclusions According to our results, CR can enhance the antibacterial effect of colistin against Col-R K. pneumonia, which may provide a feasible strategy for the fight against Col-R K. pneumonia.
Hydrodynamics of laminar pipe flow through an extended partial blockage by CFD
Authors: Martins Nuno M. C. , Covas Dídia I. C. , Meniconi Silvia , Capponi Caterina , Brunone Bruno 
Published: November 2023

Abstract
In this paper, an advanced three-dimensional (3D) computational fluid dynamics (CFD) model is used to analyse the steady-state hydrodynamics of laminar flow through an extended partial blockage (PB) in a pressurised pipe. PB corresponds to one of the main faults affecting pipelines. In fact, it reduces its carrying capacity with economic consequences, and as it does not give rise to any external evidence, its detection can be very challenging. The performance of the model is evaluated by comparing the numerical results with the available experimental data from the literature. Subsequently, the velocity and pressure distributions are analysed, and the main features of the flow field are described in terms of both local and global dimensionless parameters. Furthermore, the behaviour of the discharge coefficient is also investigated. The obtained results confirm that steady-state measurements can identify the presence of PB and follow its evolution over time but cannot detect its location and size. On the other hand, the location and severity of PBs can be provided by means of transient tests.
Design and Pharmacophore Study of Triazole Analogues as Aromatase Inhibitors
Authors: Banjare Laxmi 
Published: November 2023

Background:
In current scenario breast cancer measured as one of the dangerous health issues. An
effective therapeutic class of drug known as aromatase inhibitors (AIs) is dominant against estrogen receptorpositive
breast cancer. However, there is an urgent need to create target-specific AIs with better anti-breast cancer
profiles due to the increased toxicity and adverse effects related to currently existing anti-breast cancer drugs.

Objectives:
In the present study, we have designed of 100 novel tiazole analogues as aromatase inhibitors their
pharmacophoric features were explored.

Method:
Molecular docking was applied to a series of 4-substituted-1, 2, 3-triazoles containing letrozole for their
aromatase inhibitory effects. The aromatase inhibitory activity of the compound in a series varies in the range of
(IC50 = 0.008–31.26 μM). A hydrogen atom positioned at R1 of the triazole ring in compound (01) was responsible
for the most potent compound (IC50 = 0.008 μM) in the series of 28 compounds as compared to letrozole. The
self-organizing molecular field study was used to assess the molecular characteristics and biological activities of
the compounds. The four models were developed using PLS and MLR methods. The PLS method was good for
statistical analysis. The letrozole scaffold-based 100 compounds were designed by selecting an effective pharmacophore
responsible for aromatase inhibitory activity. The designed compound was placed on the previous model
as a test set, and its IC50 values were calculated.

Result:
Hydrogen bonds were established between the potent molecule (01) and the essential residues Met 374
and Arg 115, which were responsible for the aromatase-inhibiting action. Cross-validated q2 (0.6349) & noncross-
validated r2 (0.7163) were discovered in the statistical findings as having reliable predictive power. Among
100 designed compounds, seven compounds showed good aromatase inhibitory activities.

Conclusion:
The additional final SOMFA model created for the interactions between the aromatase and the triazole
inhibitors may be helpful for future modification and enhancement of the inhibitors of this crucial enzyme.
Decentralization and Virtualization of INR-based Anticoagulation Control
During the COVID-19 Pandemic
Authors: Almesned Abdulrahman , Alqwaee Abdullah , Abusiryeh Bayan , Almeman Ahmad 
Published: November 2023

Objective:
To investigate the effectiveness of the decentralization and virtualization of
anticoagulation clinics just before and during the coronavirus disease 2019 (COVID-19) pandemic

Methods:
We conducted a cohort study investigation at Prince Sultan Cardiac Clinics PSCC
Qassim region, Saudi Arabia. To evaluate the effectiveness of the virtual coagulation clinic, we
calculated the time in therapeutic range (TTR), Morisky score for adherence, and satisfaction.
Demographics of the patients were analyzed to group patients based on their regions or districts
to facilitate the visits. Thirteen different PHCs/Hospitals were allocated for decentralization
based on patient density in that region. Intensive courses were provided for all general practitioners (GPs) regarding warfarin anticoagulation and point of care testing (POCT) using iSTAT.
All appointments were scheduled by WhatsApp, with no more actual visits to the main center.

Results:
Among the included participants (n = 5616), 61.1% were females, 38.9% were males,
and the mean age was 60.5 (18-85) years. The total number of clinic visits was 7303 per month,
with an average of 1.3 visits per patient. Approximately 95% of the participants had a valvular
indication to receive anticoagulation; of them, 55% underwent mitral valve replacement. Moreover, after the virtualization of the INR clinic, keeping INR levels within a therapeutic range was
reported in 80% of patients. Regarding patient satisfaction, 90% of the total population was satisfied by the new experience.

Conclusion:
Decentralization and virtualization of the INR clinic have similar TTR results if
conducted properly.
Evaluation of Adverse Effects after the Second Dose of BNT162b2 Mrna Vaccination for COVID-19: A Survey-based Analysis among Italian Healthcare Workers
Authors: Ferrazza Gianluigi , Nucera Alessandro , Longo Susanna , Ferrari Cristiana , Mazza Andrea , Magrini Andrea , Coppeta Luca , Rizza Stefano 
Published: November 2023

Backgrounds and Aims:
Since the start of the SARS-CoV-2 pandemic, healthcare workers have been at elevated risk of contracting COVID-19. Although COVID-19 vaccines have contributed to the eradication of, or substantial decreases in, the incidence of lethal diseases, the major determinant of COVID-19 vaccine hesitancy is a fear of associated adverse effects. Here, we performed a survey assessing the reactogenicity and safety of BNT162b2 in a real-world setting.

Methods:
Data were collected from March 1 and June 14, 2021. A total of 206 hospital employees undergoing BNT162b2 mRNA vaccination completed the survey. These hospital workers received a questionnaire to collect the common and uncommon adverse effects developing 2–6 days after the second dose of the Pfizer-BioNTech vaccine.

Results:
After the second dose, female sex was found to be associated with a higher risk of vaccine-related severe systemic adverse effects than male sex (odds ratio [OR] 3.116, 95% CI 2.365–7.113). We also observed that the anti-SARS-CoV-2 receptor-binding domain titer, determined on the day when the second dose of the Pfizer-BioNTech vaccine was administered, was significantly higher in participants with severe systemic effects than those without such effects (OR 1.017, 95% CI 1.001–1.034).

Conclusion:
Our study suggested that healthy female healthcare workers had a three-fold higher risk than healthy male healthcare workers of developing severe adverse effects after the second dose of the Pfizer-BioNTech vaccine. Further research is warranted to determine whether a high anti-SARS-CoV-2 RBD titer determined at the time of the second vaccination might indicate a disproportionate inflammatory systemic reaction leading to severe adverse effects. Our findings might contribute to a decrease in the disappearance of COVID-19 vaccine hesitancy.
Manufacturing of Tungsten Micro-tools by Electrochemical Etching:
Study of the Electrical Parameters
Authors: Tafraouti Asmae , Kleimann Pascal , Layouni Yasmina 
Published: November 2023

Introduction:
This paper aims to fabricate the high aspect ratio tungsten micro-tools with
diameters up to 80µm by electrochemical etching. This process is simple and easy to develop, but it
requires a deep study to achieve the fabrication of micro-tools with a diameter of 5 µm.

Methods:
This paper aims to fabricate the high aspect ratio tungsten micro-tools with
diameters up to 80μm by electrochemical etching. This process is simple and easy to develop, but it
requires a deep study to achieve the fabrication of micro-tools with a diameter of 5 μm

Results:
The experiments show that VON = 0.5 V leads to satisfactory results (validation of the reproducibility,
homogeneous etching, and fabrication of micro-tools with a diameter of 80 μm with an
initial tungsten wire diameter of 250 μm) by applying an etching charge of 13 C. Voltages VON = 0.1
V and VON = 1 V does not ensure homogeneous etching. A rest phase TOFF = 3 s allows obtaining micro-
tools with a diameter of 80 μm in 7 min. For a rest phase of TOFF = 9 s, the etching takes 20 min
and the micro-tool diameter is almost the same.

Conclusion:
The results of this study will be used in the manufacture of cylindrical micro-tools with
a high aspect ratio Fc > 100.
Impact of COVID-19 on the Pediatric Primary Care Model in Catalonia: Analysis of Changes in the Number and Type of Face-to-Face and Remote Visits
Authors: Castillo-Rodenas Marta , Vicente Gómez José Ángel , Fuster-Casanovas Aïna , Miró Catalina Queralt , Vidal-Alaball Josep , López Seguí Francesc 
Published: November 2023

Abstract

Background
The outbreak of COVID-19 has turned the care model of health systems around the world upside down. The health care crisis has led to opportunities for digital health to deliver quality care, and the system has been redirected toward telemedicine. In Catalonia, Spain, as of March 2020, the pattern of visits in primary care pediatric consultations changed, such that face-to-face visits decreased in favor of non–face-to-face visits.

Objective
This study aimed to analyze variations in the types of pediatric visits in primary care centers in Catalonia before and after the onset of COVID-19.

Methods
This was a descriptive observational study based on administrative data. The number and type of visits to primary care pediatric services in Catalonia between January 2019 and December 2022 were studied.

Results
A drop of more than 80% in face-to-face visits and an increase of up to 15 times in remote visits were observed as of March 2020 compared to the previous year. Subsequently, the face-to-face attendance rate began to recover, although it did not reach the same rate as before COVID-19. Non–face-to-face visits were maintained, representing more than 20% of the total after more than 2 years of the pandemic.

Conclusions
COVID-19 has been the trigger for a transition in the types of visits to primary care pediatric services. The COVID-19 pandemic was a clear catalyst for the integration of telemedicine in Catalan pediatric health care. In this context, although face-to-face consultations have recovered in absolute numbers, after the pandemic period, the weight of telemedicine has increased.