bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCL1A+ B cells predict prognosis in triple-negative breast cancer through integrative analysis of single-cell and bulk transcriptomic data
Authors: Hou Peifeng , Luo Yang , Wu Ningzi 
Published: September 2023

Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and high mortality rates. It remains a prevailing clinical need to distinguish whether the patient can benefit from therapy, such as chemotherapy. By integrating single-cell and global transcriptome data, we have for the first time identified TCL1A+ B cell functions that are prognostically relevant in TNBC. This finding broadens the perspective of traditional tumor-infiltrating lymphocytes in predicting survival, especially the potential value of B cells in TNBC. Single-cell RNA-seq data from five TNBC patients were collected to identify the association between immune cell populations and clinical outcomes. Functional analysis was according to gene set enrichment analysis using pathways from MsigDB. Subsequently, the gene signature of TCL1A+ B cells based on differential expression genes of TCL1A+ B cells versus other immune cells was used to explore the correlation with tumor microenvironment (TME) and construct a prognostic signature using a non-parametric and unsupervised method. We identified TCL1A+ B cells as a cluster of B cells associated with clinical outcomes in TNBC. Functional analysis demonstrated its function in B cell activation and regulation of immune response. The highly enriched TCL1A+ B cell population was found to be associated with a thermal TME with anti-tumor effects. A high abundance of TCL1A+ B cell population is positively correlated with a favorable therapeutic outcome, as indicated by longer overall survival. The present study suggests that TCL1A+ B cells play a key role in the treatment and prognostic prediction of TNBC, although further studies are needed to validate our findings. Moreover, the integration of transcriptome data at various resolutions provides a viable approach for the discovery of novel prognostic markers.
Microbiological transglutaminase: Biotechnological application in the food industry
Authors: Kolotylo Vitaliy , Piwowarek Kamil , Kieliszek Marek 
Published: September 2023

Abstract
Microbial transglutaminases (mTGs) belong to the family of global TGs, isolated and characterised by various bacterial strains, with the first being Streptomyces mobaraensis. This literature review also discusses TGs of animal and plant origin. TGs catalyse the formation of an isopeptide bond, cross-linking the amino and acyl groups. Due to its broad enzymatic activity, TG is extensively utilised in the food industry. The annual net growth in the utilisation of enzymes in the food processing industry is estimated to be 21.9%. As of 2020, the global food enzymes market was valued at around $2.3 billion USD (mTG market was estimated to be around $200 million USD). Much of this growth is attributed to the applications of mTG, benefiting both producers and consumers. In the food industry, TG enhances gelation and modifies emulsification, foaming, viscosity, and water-holding capacity. Research on TG, mainly mTG, provides increasing insights into the wide range of applications of this enzyme in various industrial sectors and promotes enzymatic processing. This work presents the characteristics of TGs, their properties, and the rationale for their utilisation. The review aims to provide theoretical foundations that will assist researchers worldwide in building a methodological framework and furthering the advancement of biotechnology research.
Diagnostic performance of automated red cell parameters in predicting bone marrow iron stores
Authors: Paabo Triin , Mihkelson Piret , Beljantseva Jelena , Rähni Ain , Täkker Signe , Porosk Rando , Kilk Kalle , Reimand Katrin 
Published: September 2023

Abstract

Objectives
The aim of the study was to determine the diagnostic performance of novel automated red cell parameters for estimating bone marrow iron stores.

Methods
The study was a retrospective single-centre study based on data from an automated haematology analyser and results of bone marrow iron staining. Red cell parameters were measured on a Sysmex XN-series haematology analyser. Bone marrow iron stores were assessed semiquantitatively by cytochemical reaction according to Perls.

Results
The analysis included 429 bone marrow aspirate smears from 393 patients. Median age of patients was 67 years, 52 % of them were female. The most common indication for bone marrow examination was a plasma cell dyscrasia (n=104; 24 %). Median values of percentage of hypochromic and hyperchromic red blood cells (%HYPO-He, %HYPER-He), reticulocyte haemoglobin equivalent (RET-He) and microcytic red blood cells (MicroR) were statistically significantly different between cases with iron deplete and iron replete bone marrow. In a logistic regression model, ferritin was the best predictor of bone marrow iron stores (AUC=0.891), outperforming RET-He and %HYPER-He (AUC=0.736 and AUC=0.722, respectively). In a combined model, ferritin/MicroR index achieved the highest diagnostic accuracy (AUC=0.915), outperforming sTfR/log ferritin index (AUC=0.855).

Conclusions
While single automated red cell parameters did not show improved diagnostic accuracy when compared to traditional iron biomarkers, a novel index ferritin/MicroR has the potential to outperform ferritin and sTfR/log ferritin index for predicting bone marrow iron stores. Further research is needed for interpretation and implementation of novel parameters and indices, especially in the context of unexplained anaemia and myelodysplastic syndromes.
Auditivierung des textkritischen Apparats
Authors: Cividini Iacopo 
Published: October 2023

Abstract
Since their emergence in the 19th century, the aim of critical editions has not only been to publish philologically reliable texts, but also to make the decisions on the basis of the editorial process as transparent as possible. In the specific case of the music edition, however, the formulation of editorial decisions in a critical apparatus is complicated by the semiotic discrepancy between the sign system of musical text and its verbalised annotation in the fundamentally different sign system of linguistic text. This unbridgeable medial gap between the musical text and its verbal account caused the original editorial object to be split apart within printed editions of the 20th century: between the edited text and the critical report on the one hand, and again between practical editions for the general public and scholarly editions for the small circle of qualified musicologists on the other hand.
Using the Digital Mozart Edition as an example, this article shows how a digital format can, through its audio-visual multimedia, both create spaces for the integration of the critical apparatus into the edited text and enable a ‘deverbalization’ of the critical vocabulary that conveys the documentation of editorial decisions in musical form more intuitively and more precisely. The digital medium makes it possible for critical editions of music to come closer to the ideal of an open edition in the sense of an ‘edition of the edition’, in which not only the text itself, but also the editorial process that led to this text is, in turn, edited and made immediately accessible to the user.
Kleider machen Leute
Authors: Busch Nathanael 
Published: October 2023

Abstract
The appraisal and evaluation of the 16th century poet Hans Sachs is dominated by stereotypes and often made without knowledge of the texts. The edition of the complete works edited by Adelbert von Keller and Edmund Goetze (1870–1908), which is still in use today, perpetuates these stereotypes and devalues the poet. On the groundwork of various aspects (order, paratexts, variance, errors, normalisation), objections to the edition are discussed and suggestions are made as to what a new edition should look like.
Pörtner & Wühr: Spuren des Original-Ton-Hörspiels zwischen Wuppertal und München
Authors: Lukas Wolfgang , Machwitz Dana , Politycki Bastian 
Published: October 2023

Abstract
The Wuppertal exhibition Pörtner & Wühr: Spuren des Original-Ton-Hörspiels zwischen Wuppertal und München, which was shown from November 2022 to January 2023 in the University Library of Wuppertal represented an attempt to provide an insight into the production workshop of two pioneers of original tone radio plays, Paul Pörtner (1925–1984) and Paul Wühr (1927–2016). Selected handwritten and typewritten documents from the bequests of the two authors made the genesis and production aesthetics vivid. The analogue exposition was complemented by a media station that offered an additional digital exhibition space for in-depth exploration.
50 Jahre Texte und Varianten
Authors: Martens Gunter 
Published: October 2023

Abstract
In 1971, more than 50 years ago, the anthology Texte und Varianten was published by C. H. Beck in Munich. Gunter Martens, who edited the volume together with the Swiss philologist Hans Zeller, recalls in this article the background to the preparation of this historical monument of scholarly editing. With quotations from the minutes of two colloquia, organized by the Deutsche Forschungsgemeinschaft in Bad Godesberg in October 1967 and in Marbach am Neckar in May 1968, and excerpts from letters of the two editors, the article documents the reasons that led to the anthology.
Die Vorgeschichte von Texte und Varianten im Licht des Briefwechsels von Hans Zeller mit Siegfried Scheibe
Authors: Zeller Rosmarie 
Published: October 2023

Abstract
Based on the correspondence between Siegfried Scheibe (GDR) and Hans Zeller (Switzerland), the antecedents of the anthology Texte und Varianten (1971) are examined. In the wake of the discussion about how to present the genesis of literary texts, a need for a handbook apparently arose. Hans Zeller, together with Siegfried Scheibe, intended to publish a handbook that would reflect the state of the art concerning concepts such as the choice of the textual witness regarding the text constitution, the question of authorization of a text or the presentation of variants. Scheibe was initially forbidden to publish his contribution, which finally appeared in Texte und
Varianten, like the one of Hans Zeller.
Efektivitas Penggunaan Microsoft Teams sebagai Media Pembelajaran pada Mata Pelajaran IPS (Studi Kasus Kelas VIII MTsN 1 Kota Tangerang Selatan
Authors: Hidayati Erika , Windarti Anissa , Ardiansyah Andri Noor 
Published: October 2023

Abstrak Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan Microsoft Teams sebagai media pembelajaran pada mata pelajaran IPS. Penelitian ini dilakukan di MTsN 1 Kota Tangerang Selatan. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan teknik analisis data Miles dan Huberman yang terdiri dari reduksi data, penyajian data dan kesimpulan atau verifikasi. Instrumen yang digunakan dalam penelitian ini yaitu pedoman observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukkan bahwa penggunaan Microsoft Teams sebagai media pembelajaran pada mata pelajaran IPS dikategorikan tidak efektif, dapat dilihat berdasarkan pada indikator efektivitas pembelajaran menurut Slavin yaitu mutu pengajaran, tingkat pengajaran yang tepat, insentif dan waktu yang harus saling berkesinambungan antara satu dengan lainnya agar dapat dinyatakan efektif. Semua aspek atau indikator dari efektivitas saling berkesinambungan antara satu dengan lainnya dan telah memenuhi kriteria untuk dinyatakan efektifKata Kunci: Efektivitas, Microsoft Teams, Media Pembelajaran AbstractThis study aims to determine the effectiveness of using Microsoft Teams as a learning medium in social studies subjects. This research was conducted at MTsN 1 South Tangerang City. The research method used is descriptive qualitative with data analysis techniques Miles and Huberman consisting of data reduction, data presentation and conclusions or verification. The instruments used in this research are observation, interview and documentation guidelines. The results of this study indicate that the use of Microsoft Teams as a learning medium in social studies subjects is categorized as ineffective, it can be seen based on the indicators of learning effectiveness according to Slavin, namely the quality of teaching, the right level of teaching, incentives and time that must be mutually sustainable with one another in order to achieve success. declared effective. All aspects or indicators of effectiveness are mutually sustainable with each other and have met the criteria to be declared effectiveKeywords: Effectiveness, Microsoft Teams, Learning Media
Effect of Viral Illness on Procalcitonin as a Predictor of Bacterial Infection in Febrile Infants
Authors: Kusma Jared , Fu Quinney , Kafle Maheshwor , Librizzi Jamie , Mirea Lucia , Riggins Hannah , Stone Daniel , Wall Jillian , Gage Sandra 
Published: October 2023

OBJECTIVE
The impact of confirmed viral infections (CVI) on procalcitonin (PCT) levels in febrile infants aged 8–60 days with a bacterial illness (BI) is unknown. The objectives of the study were to (1) examine the association of CVI with PCT levels in patients with/without a concurrent BI, defined as bacteremia, meningitis, or urinary tract infection, and (2) assess PCT as a predictor of BI in infants with a concurrent CVI.

METHODS
In this single-center, retrospective cohort study, we examined febrile infants aged 8–60 days presenting between January 1, 2018 and December 31, 2020. PCT levels were compared between groups, according to results of bacterial cultures and viral tests, using the Wilcoxon rank test. The prediction ability of PCT to detect BI with/without concurrent CVI was assessed by using area under the curve from logistic regression.

RESULTS
Patients included: 404 BI−/CVI+, 73 BI+/CVI−, 48 BI+/CVI+, and 138 BI−/CVI−. Median PCT level in the BI+/CVI+ group was significantly lower when compared to BI+/CVI− (0.36 ng/mL vs 0.89 ng/mL), but significantly higher than the BI−/CVI− group (0.36 ng/mL vs 0.1 ng/mL). The presence of a CVI reduced the sensitivity of PCT in BI detection (68% vs 44%), with minimal impact specificity (93% vs 96%).

CONCLUSIONS
In previously healthy febrile infants 8–60 days old, the presence of a CVI reduces the sensitivity of PCT BI detection without impacting its specificity. The impact of a CVI on PCT levels in febrile infants has implications for how this marker of infection should be considered when assessing risk of BI in infants.
Πλάνο Φροντίδας Νεογνού με Περιγεννητική Ασφυξία
Authors: Μεταλλινού Δήμητρα , Γκοζίτα Έλενα , Αποστολίδη Δήμητρα-Μαρία , Νάνου Χριστίνα Ι. 
Published: September 2023

ΕισαγωγήΗ περιγεννητική ασφυξία αποτελεί μια σοβαρή κατάσταση που συνδέεται με νεογνική νοσηρότητα και θνητότητα και η εμφάνισή της έχει συσχετιστεί με πολλούς παράγοντες κινδύνου, γεγονός που καταδεικνύει την πολυπλοκότητά της. Παρά τη σημαντική πρόοδο που έχει σημειωθεί στην περιγεννητική φροντίδα, αποτελεί την τρίτη πιο συχνή αιτία νεογνικού θανάτου, έπειτα από τις σοβαρές λοιμώξεις και τον πρόωρο τοκετό, με συχνότητα εμφάνισης 1 έως 6 ανά 1.000 ζωντανές τελειόμηνες γεννήσεις.

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<b></b>ΣκοπόςΣκοπός αυτής της ανασκόπησης είναι να παρουσιαστούν τα νεότερα βιβλιογραφικά δεδομένα αναφορικά με την περιγεννητική ασφυξία και να αναλυθεί το πλάνο φροντίδας των πασχόντων νεογνών μέσω υποστηρικτικών μέτρων.ΜέθοδοιΠραγματοποιήθηκε ανασκόπηση της ελληνικής και διεθνούς βιβλιογραφίας στις ηλεκτρονικές βάσεις δεδομένων PubMed, Medline Plus, Google Scholar και Scopus. Το υλικό της μελέτης αποτέλεσαν επιλεγμένα άρθρα δημοσιευμένα την τελευταία εικοσαετία. Υπήρξε περιορισμός ως προς τη γλώσσα δημοσίευσης των άρθρων και χρησιμοποιήθηκαν κυρίως άρθρα που δημοσιεύτηκαν στα αγγλικά και στα ελληνικά.ΑποτελέσµαταΣυγκεκριμένα κριτήρια έχουν καθιερωθεί για τον ορισμό ενός υποξικού-ισχαιμικού συμβάντος που μπορεί να προκαλέσει μέτρια έως σοβαρή νεογνική εγκεφαλοπάθεια. Πιο συγκεκριμένα, η παρουσία σοβαρής μεταβολικής οξέωσης κατά τη γέννηση, δηλαδή pH < 7 και έλλειμμα βάσης ≥ 12 mmol/L, αποτελεί κύριο εύρημα της εν λόγω νοσηρότητας. Για τη διαχείριση και αξιολόγηση ενός νεογνού με ασφυξία, απαιτούνται κλινικές και εργαστηριακές εξετάσεις, ενώ τα θεραπευτικά μέτρα αποσκοπούν στην υποστήριξη των συστημάτων του οργανισμού του νεογνού.ΣυµπεράσµαταΗ περιγεννητική ασφυξία μπορεί να επηρεάσει σχεδόν οποιοδήποτε όργανο του σώματος του νεογνού και η πρόγνωση εξαρτάται από τη σοβαρότητα του συμβάντος. Μόνο ένα μικρό ποσοστό των νεογνών επιβιώνει χωρίς επιπλοκές. Η θεραπεία υποθερμίας μετά από περιγεννητική ασφυξία έχει αποδειχθεί ότι παρέχει νευροπροστασία, η οποία είναι ικανή να μειώσει τον κίνδυνο θανάτου και νευροαναπτυξιακής αναπηρίας. Υπάρχουν, επίσης, πολλοί νευροπροστατευτικοί παράγοντες που μπορούν να μειώσουν τη βλάβη που προκαλείται στον εγκέφαλο από την υποξία-ισχαιμία, αλλά πρέπει να διερευνηθούν περαιτέρω για την αξιολόγηση της αποτελεσματικότητάς τους.
Jóvenes víctimas de violencias, caras tatuadas y borramientos
Authors: Cerbino Mauro 
Published: October 2023

En este texto se propone repensar las modalidades de la violencia pandilleril, señalando un conjunto de causas que subyacen a esa violencia, la cual, al insertarse en el círculo de las violencias, permite problematizar la oposición entre víctimas y victimarios. Se toma el caso de las maras centroamericanas para desarrollar una interpretación del gesto de tatuarse la cara como una práctica que evidencia algunas de las formas en que los jóvenes, a la vez que ejercen violencia, la padecen. Además, se analiza el borramiento de los tatuajes de la piel interpretándolo como la escenificación de una violencia institucional aún más intensa. Estas prácticas se interpretan enfatizando algunos aspectos relacionados con los significados de posiciones de subjetivación o de sujetamiento.AbstractThis article tries to rethink the diverse modalities of gang violence, and proposes a set of causes that explain them. It explores the spiral of violence, and the opposition between victims and perpetrators. Specifically, the paper looks at the case of the Central American maras and offers an interpretation of the act of tattooing the face, as a practice that shows paradoxically how young people suffer violence in exercising of violence. Furthermore, we analyze the practice of erasing tattoos from the skin as sign of a much more intense institutional violence. The interpretation of these practices emphasizes some of the aspects related to the meanings of positions of subjectivation.
Gobernanza: una mirada desde América Latina
Authors: Zurbriggen Cristina 
Published: October 2023

El concepto de gobernanza adquiere cada vez más trascendencia en los debates teóricos europeos y en la práctica política, en tanto nuevo modo de gestionar las políticas públicas, a partir de las reformas del sector público en los años ochenta. Sin embargo, el debate en América Latina ha tenido características diferentes que el europeo, por lo que es necesario aportar una revisión crítica de la agenda propuesta para la transformación del Estado en la región y la transferencia de la noción degovernance por los organismos multilaterales. Para comprender estas transformaciones, aquí se analizan tres áreas centrales de las reformas estatales emprendidas en América Latina: la privatización de servicios públicos, las nuevas ofertas de políticas sociales y los procesos de descentralización. Ello nos permitirá entender la tensión entre los modelos normativos y los particulares patrones de gobernanza que predominan en América Latina.AbstractGovernance is becoming an increasingly important concept in European theoretical debates and in political practice as a new way to manage public policies, since the public sector reforms in the 80s. However, the debate in Latin America has different characteristics than in Europe, so it is necessary to provide a critical review of the proposed agenda for the transformation of the state in the region, and of the transfer of the concept of governance by multilateral agencies. To understand these changes the paper examines three key areas of reforms in Latin America and the privatization of public services, new social policies proposals and the decentralization process. This will help us understand the tension between normative models and specific patterns of governance that prevail in Latin America.
La estrategia contra el crimen organizado en México: análisis del diseño de la política pública
Authors: Montero Juan Carlos 
Published: October 2023

Este artículo parte del reconocimiento de la amenaza que implica el crimen organizado para un régimen democrático y analiza la política que, para combatirlo, se ha adoptado en México durante la gestión del presidente Felipe Calderón. Asimismo, se cuestiona si el gobierno considera este asunto como de seguridad pública o de seguridad nacional. El hallazgo principal revela que el objetivo del gobierno federal no es combatir el crimen organizado sino la violencia que éste genera, y que para ello ha implementado una política basada principalmente en el uso de la fuerza pública, factor que no facilita la colaboración inter e intragubernamental por los conflictos que surgen cuando se articulan las políticas de seguridad pública con las de seguridad nacional.Abstract This paper is based on the assumption that the organized crime is a menace for democracy. The article develops an analysis on the fight against organized crime's policy design in the Felipe Calderon's government, questioning if the policy is managed as a police's issue or a national security's issue. The main finding is the identification of the Mexican's government objective in the "war against organized crime" switching the focus from organized crime to the violence created by criminal organizations. To fight violence the government implements a policy based on the use of public force that doesn't consider the cooperation between different governmental agencies.
Entre el cargo, la maternidad y la doble jornada. Presidentas municipales de Oaxaca
Authors: Vázquez García Verónica , Cárcamo Toalá Naima Jazíbi , Hernández Martínez Neftalí 
Published: October 2023

La participación de las mujeres en la política municipal enfrenta, en México, entre otras dificultades, la de conciliar las responsabilidades domésticas con las de un cargo público. A partir de un estudio de dieciocho casos de presidentas municipales de Oaxaca, el presente artículo analiza la forma en que ellas perciben la relación entre maternidad, doble jornada (crianza de hijos/as y trabajo doméstico) y cargo presidencial, así como las estrategias con las que conciban los roles materno y político. La metodología consistió en entrevistar a todas las presidentas que han gobernado un municipio usocostumbrista oaxaqueño desde 1996 hasta la fecha de lo que derivaron dos conclusiones principales: a) la relación entre maternidad y presidencia depende del estado civil de las mujeres, de la edad de sus hijos e hijas y de la posibilidad de contratar ayuda doméstica; y b) el hecho de que las mujeres tengan un puesto de prestigio y responsabilidad no las exenta del trabajo doméstico ni tampoco se generan reestructuraciones para que el mismo se reparta entre los integrantes del núcleo familiar.AbstractIn México, women's participation in municipal politics faces, among other difficulties, that of reconciling domestic and public responsibilities. Drawing on research conducted with eighteen female mayors of Oaxaca, this paper analyzes the ways in which women perceive the relationship between motherhood, double burden (child raising and domestic work) and their presidential position. All the women who have ruled a Custom and Practice municipality in Oaxaca since 1996 were interviewed. Two main conclusions are drawn from the analysis. First, the relationship between motherhood and presidential position varies according to women's marital status; the age of their children; and their chances of hiring domestic help. Second, even if women assume a public position of prestige and responsibility, they continue to perform domestic duties; household chores do not get redistributed among its members.