bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allylation of Alcohols and Carboxylic Acids with Allyl Acetate Catalyzed by [Ir(cod)2]+BF‐4 Complex.
Authors: Nakagawa Hideto , Hirabayashi Tomotaka , Sakaguchi Satoshi , Ishii Yasutaka 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Transformations of Metallacycles. Part 32. Novel Method for the Synthesis of Cyclopentanols from Aluminacyclopentanes.
Authors: Dzhemilev U. M. , Ibragimov A. G. , Khafizova L. O. , Gilyazev R. R. , D'yakonov V. A. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereodefined and Polyunsaturated Inhibitors of Histone Deacetylase Based on (2E,4E)‐5‐Arylpenta‐2,4‐dienoic Acid Hydroxyamides.
Authors: Marson Charles M. , Serradji Nawal , Rioja Alphonso S. , Gastaud Sebastien P. , Alao John P. , Coombes R. Charles , Vigushin David M. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Conjugate Additions of α,β‐Unsaturated Ketones with Arylzinc Species that Form in situ from Diethylzinc and Arylboronic Acids.
Authors: Dong Lin , Xu Yan‐Jun , Gong Liu‐Zhu , Mi Ai‐Qiao , Jiang Yao‐Zhong 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of Diaryl Ketones by Iron‐Catalyzed Arylation of Aroyl Cyanides.
Authors: Duplais Christophe , Bures Filip , Sapountzis Ioannis , Korn Tobias J. , Cahiez Gerard , Knochel Paul 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intramolecular Cyclization and Disilylation of 1,1‐Dicyano‐2,2‐diarylethenes Promoted by Samarium/TMSCl in DMF: A New Approach to the Syntheses of Polysubstituted Indenes.
Authors: Liu Yongjun , Zhao Qinliang , Zhang Yongmin 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Radical Roundabout for an Unprecedented Tandem Reaction Including a Homolytic Substitution with a Titanium—Oxygen Bond.
Authors: Gansaeuer Andreas , Rinker Bjoern , Ndene‐Schiffer Noellie , Pierobon Marianna , Grimme Stefan , Gerenkamp Mareike , Mueck‐Lichtenfeld Christian 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Interaction of Dihydropyridines and Nucleophiles with Carbene Complexes of Chromium: Diastereo‐ and Enantioselective Synthesis of Polycyclic Butenolides.
Authors: Rudler Henri , Parlier Andree , Certal Victor , Lastennet Gabriel , Audouin Max , Vaissermann Jacqueline 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Application of Alkyl 3‐Dimethylamino‐2‐(1H‐indol‐3‐yl)propenoates in the Synthesis of 3‐Heteroarylindoles.
Authors: Jakse Renata , Svete Jurij , Stanovnik Branko , Golobic Amalija 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Solvent‐Free Indoles Addition to Carbonyl Compounds Promoted by CeCl3×7H2O—NaI—SiO2: An Efficient Method for the Synthesis of Streptindole.
Authors: Bartoli Giuseppe , Bosco Marcella , Foglia Gioia , Giuliani Arianna , Marcantoni Enrico , Sambri Letizia 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reeve′s Synthesis of 2‐Imino‐4‐thiazolidinone from Alkyl (Aryl) Trichloromethylcarbinol Revisited: A Three‐Component Process from Aldehyde, Chloroform and Thiourea.
Authors: Blanchet Jerome , Zhu Jieping 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Facile Synthesis of Imidazo[2,1‐b]‐1,3,4‐thiadiazol‐5(6H)‐ones via Aza‐Wittig Reaction.
Authors: Ding Ming‐Wu , Fu Bo‐Qiao , Cheng Lin 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ruthenium‐Catalyzed Cycloaddition Between Propargylic Alcohols and Cyclic 1,3‐Dicarbonyl Compounds via an Allenylidene Intermediate.
Authors: Nishibayashi Yoshiaki , Yoshikawa Masato , Inada Youichi , Hidai Masanobu , Uemura Sakae 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Inverse Electron Demand Diels—Alder Reactions of Heterodienes Catalyzed by Potassium Hydrogen Sulfate: Diastereoselective, One‐Pot Synthesis of Pyranobenzopyrans, Furanobenzopyrans and Tetrahydroquinolines Derivatives.
Authors: Kumar R. Senthil , Nagarajan Rajagopal , Perumal Paramasivan T. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Evaluation of 1‐Arylsulfonyl‐3‐piperazinone Derivatives as Factor Xa Inhibitors. Part 3. Effect of Ring Opening of Piperazinone Moiety on Inhibition.
Authors: Nishida Hidemitsu , et al. et al. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Approach to 1,2‐Dihydro‐2‐oxo‐3‐pyridinecarboxylic Ester via Aromatization Induced by Deamidation.
Authors: Yu Gang , Wang Shaozhong , Wang Kai , Hu Yuefei , Hu Hongwen 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Mesoionic Systems of the Azolopyridine Series. Part 1. Synthesis and Structures of Thiazolo[3,2‐a]pyridinium 2‐Thiolates.
Authors: Babaev E. V. , Rybakov V. B. , Orlova I. A. , Bush A. A. , Maerle K. V. , Nasonov A. F. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Anti‐Aggregating Activity of Hydrochlorides of 3‐(2‐Aryl‐2‐oxoethyl)‐3‐methoxy‐2‐oxo‐2,3‐dihydroimidazo [1,2‐a]pyridines.
Authors: Kataev S. S. , Syropyatov B. Ya. , Gavrilova N. E. , Zalesov V. V. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of Fused 1,2,4‐Triazolo[1,5‐c]pyrimidine Derivatives as Human Adenosine A3 Receptor Ligands.
Authors: Okamura Takashi , Kurogi Yasuhisa , Hashimoto Kinji , Nishikawa Hiroshi , Nagao Yoshimitsu 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ring Contraction in Reactions of 3‐Benzoylquinoxalin‐2‐ones with 1,2‐Phenylenediamines. Quinoxaline—Benzoimidazole Rearrangement.
Authors: Mamedov V. A. , Kalinin A. A. , Gubaidullin A. T. , Chernova A. V. , Litvinov I. A. , Levin Ya. A. , Shagidullin R. R. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Cross‐Coupling of Perfluoroalkenyl Zinc Reagents with 5‐Halo‐6‐azauracils.
Authors: Wojtowicz‐Rajchel Hanna , Bednarczyk Irena , Katrusiak Andrzej , Koroniak Henryk 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 8‐Aryl[1,2,4]triazolo[1,5‐d][1,2,4]triazin‐5(6H)‐ones by SHN Reactions.
Authors: Rusinov V. L. , Zyryanov G. V. , Egorov I. N. , Ulomskii E. N. , Aleksandrov G. G. , Chupakhin O. N. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Binuclear and Polynuclear Transition Metal Complexes with Macrocyclic Ligands. Part 3. New Polydentate Macrocyclic Ligands in Reactions of 4‐Alkyl‐2,6‐diformylphenols with 1,2‐Diaminobenzenes.
Authors: Borisova N. E. , Reshetova M. D. , Ustynyuk Yu. A. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Facile Approach to 2‐CF3‐Substituted Seven‐Membered Oxacycles via Stereoselective Preparation and Cope Rearrangement of 2‐CF3‐cis‐2,3‐Bis(alkenyl)oxiranes.
Authors: Shimizu Masaki , Fujimoto Takuya , Liu Xinyu , Hiyama Tamejiro 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Triselenium Dicyanide from Malononitrile and Selenium Dioxide: One‐Pot Synthesis of Selenocyanates.
Authors: Kachanov Andrey V. , Slabko Oleg Yu. , Baranova Olga V. , Shilova Evgenia V. , Kaminskii Vladimir A. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1,3‐Selenazoles and Bis(selenazoles) from Primary Selenocarboxylic Amides and Selenourea.
Authors: Geisler Karlheinz , Pfeiffer Wolf‐Diethard , Kuenzler Andreas , Below Harald , Bulka Ehrenfried , Langer Peter 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Photochromic Dihetarylethenes. Part 20. Synthesis and Photochromic Properties of Dithienylethenes with a Fixed Conformation.
Authors: Krayushkin M. M. , Ivanov S. N. , Lichitskii B. V. , Dubinov A. A. , Vorontsova L. G. , Starikov Z. A. , Martynkin A. Yu. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
3β,6β‐Dihydroxyolean‐12‐en‐27‐oic Acid: A Cytotoxic and Apoptosis‐Inducing Oleanane Triterpenoid from the Rhizome of Astilbe chinensis.
Authors: Sun Hong‐Xiang , Pan Yuan‐Jiang 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enzyme Inhibiting Terpenoids from Amberboa ramosa
Authors: Khan Sher B. , Malik Abdul , Afza Nighat , Jahan Nusrat , Haq Azhar U. , Ahmed Zaheer , Nawaz Sarfraz A. , Choudhary Mohammed Iqbal 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Clerodane Diterpene and Other Constituents from Ajuga chamaepitys ssp. laevigata
Authors: Topcu Guelacti , Koekdil Gamze , Tuerkmen Zeynep , Voelter Wolgang , Adou Eba , Kingston David G. I. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Polychlorinated Androstanes from the Burrowing Sponge Cliona nigricans.
Authors: Fattorusso Ernesto , Taglialatela‐Scafati Orazio , Petrucci Francesca , Bavestrello Giorgio , Calcinai Barbara , Cerrano Carlo , Di Meglio Paola , Ianaro Angela 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Way to 1,7‐Enynes and Ethyl 8‐Yn‐2‐enoates from Aldohexoses and to Polyhydroxylated 1‐Vinylcyclohexenes.
Authors: Dolhem Franck , Lievre Catherine , Demailly Gilles 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
On Glucosyl Thioureides: Synthesis, Antibacterial and Antifungal Studies of Certain 2‐S‐Tetra‐O‐benzoyl‐D‐glucopyranosyl‐1,5‐disubstituted‐2,4‐isodithiobiur ets.
Authors: Bhagat S. K. , Deshmukh S. P. , Musaddiq Mohammad 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nigellamines A3, A4, A5, and C, New Dolabellane‐Type Diterpene Alkaloids, with Lipid Metabolism‐Promoting Activities from the Egyptian Medicinal Food Black Cumin.
Authors: Morikawa Toshio , Xu Fengming , Ninomiya Kiyofumi , Matsuda Hisashi , Yoshikawa Masayuki 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
(+)‐Cystothiazole G: Isolation and Structural Elucidation.
Authors: Akita Hiroyuki , Sasaki Takamitsu , Kato Keisuke , Suzuki Yoshihiro , Kondo Keiko , Sakagami Youji , Ojika Makoto , Fudou Ryosuke , Yamanaka Shigeru 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antibacterial Activity of 6‐O‐Arylpropargyl‐9‐oxime‐11,12‐carbamate Ketolides.
Authors: Beebe Xenia , Yang Fan , Bui Mai H. , Mitten Michael J. , Ma Zhenkun , Nilius Angela M. , Djuric Stevan W. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
5‐Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus.
Authors: Kim Deukjoon , Min Jaeki , Ahn Soon Kil , Lee Hong Woo , Choi Nam Song , Moon Seung Kee 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bioactive Marine Metabolites. Part 127. Three New Cyclostellettamines, which Inhibit Histone Deacetylase, from a Marine Sponge of the Genus Xestospongia
Authors: Oku Naoya , Nagai Koji , Shindoh Nobuaki , Terada Yoh , van Soest Rob W. M. , Matsunaga Shigeki , Fusetani Nobuhiro 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Statin‐Derived 1,3‐Oxazinan‐2‐ones as Submicromolar Inhibitors of LFA‐1/ICAM‐1 Interaction: Stabilization of the Metabolically Labile Vanillyl Side Chain.
Authors: Ullrich Thomas , Baumann Karl , Welzenbach Karl , Schmutz Simone , Camenisch Gian , Meingassner Josef G. , Weitz‐Schmidt Gabriele 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
DNA Minor Groove Binders as Potential Antitumor and Antimicrobial Agents
Authors: Baraldi Pier Giovanni , Bovero Andrea , Fruttarolo Francesca , Preti Delia , Tabrizi Mojgan Aghazadeh , Pavani Maria Giovanna , Romagnoli Romeo 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Insights into the Mechanism of Molybdenum‐Catalyzed Asymmetric Alkylation
Authors: Krska Shane W. , Hughes David L. , Reamer Robert A. , Mathre David J. , Palucki Michael , Yasuda Nobuyoshi , Sun Yongkui , Trost Barry M. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemical mass balance when an unknown source exists
Authors: Kashiwagi Nobuhisa 
Published: August 2004

AbstractA chemical mass balance method is proposed for the case where the existence of an unknown source is suspected. In general, when the existence of an unknown source is assumed in statistical receptor modeling, unknown quantities such as the composition of an unknown source and the contributions of assumed sources become unidentifiable. To estimate these unknown quantities avoiding the identification problem, a Bayes model for chemical mass balance is constructed in the form of composition without using prior knowledge on the unknown quantities except for natural constraints. The covariance of ambient observations given in the form of composition is defined in several ways. Markov chain Monte Carlo is used for evaluating the posterior means and variances of the unknown quantities as well as the likelihood for the proposed model. The likelihood is used for selecting the best fit covariance model. A simulation study is carried out to check the performance of the proposed method. Copyright © 2004 John Wiley & Sons, Ltd.
Allowing for redundancy and environmental effects in estimates of home range utilization distributions
Authors: Hines W. G. S. , O'Hara Hines R. J. , Pond B. , Obbard M. E. 
Published: August 2004

AbstractReal location data for radio tagged animals can be challenging to analyze. They can be somewhat redundant, since successive observations of an animal slowly wandering through its environment may well show very similar locations. The data set can possess trends over time or be irregularly timed, and they can report locations in environments with features that should be incorporated to some degree. Also, the periods of observation may be too short to provide reliable estimates of characteristics such as inter‐observation correlation levels that can be used in conventional time‐series analyses. Moreover, stationarity (in the sense of the data being generated by a source that provides observations of constant mean, variance and correlation structure) may not be present. This article considers an adaptation of the kernel density estimator for estimating home ranges, an adaptation which allows for these various complications and which works well in the absence of exact (or precise) information about correlation structure and parameters. Modifications to allow for irregularly timed observations, non‐stationarity and heterogeneous environments are discussed and illustrated. Copyright © 2004 John Wiley & Sons, Ltd.
Perceived fairness of web‐based applicant screening procedures: Weighing the rules of justice and the role of individual differences
Authors: Dineen Brian R. , Noe Raymond A. , Wang Chongwei 
Published: August 2004

AbstractFour previously established characteristics of procedural justice (consistency, opportunity to perform, reconsideration opportunity, and feedback timeliness) and one additional characteristic (automated versus human decision agent) were manipulated in a policy‐capturing design to examine their relative importance in predicting fairness perceptions in a Web‐based applicant‐screening context. Results showed that all five justice characteristics influenced fairness perceptions and that a hierarchy of importance among the characteristics existed, with consistency weighted most heavily, followed by opportunity to perform. Gender, conscientiousness, and job application experience moderated the effects of several of these characteristics in predicting fairness perceptions. Implications and future research directions are discussed. © 2004 Wiley Periodicals, Inc.
Optimizing e‐learning: Research‐based guidelines for learner‐controlled training
Authors: DeRouin Renée E. , Fritzsche Barbara A. , Salas Eduardo 
Published: August 2004

AbstractThe widespread availability of the Internet has revolutionized the way organizations train their workforces. With e‐learning methods, learning can take place on‐demand, and trainees can be given greater control over their learning than ever before. This increased control has the potential to improve training effectiveness. However, the failure of many e‐learning programs suggests that organizations would benefit from a set of research‐based principles on providing learner control in e‐learning. In this article, we offer guidelines for preparing trainees for learner‐led instruction, the design of learner‐controlled training, and the creation of workplace conditions that facilitate successful learner‐led training. © 2004 Wiley Periodicals, Inc.
Technology‐assisted supplemental work: Construct definition and a research framework
Authors: Fenner Grant H. , Renn Robert W. 
Published: August 2004

AbstractExtending the workday to the home into the night and weekends is nothing new; however, the wide array of technological tools that facilitate an anytime‐anywhere connectedness of employees to their employers is a recent phenomenon. Technology‐assisted supplemental work (TASW) is the practice of lengthening working time by remaining connected to work, coworkers, supervisors, and other organizational stakeholders from home via advanced digital information technology (i.e., personal and handheld computers, cellular phones, or pagers). Although previous research offers insight into some aspects of this work form (Venkatesh & Vitalari, 1992), we present a new, broader theoretical framework that explains how organizational climate and employee characteristics promote the performance of TASW, and how both perceived usefulness of technology and satisfaction with adopted technology affect the strength of these relationships. We also explain the linkages among TASW and job performance, career success, and work‐to‐family conflict and incorporate media richness and time and boundary management as moderators of these relationships. We present propositions, offer a general research strategy, and discuss the framework's theoretical and managerial implications. © 2004 Wiley Periodicals, Inc.
The use of an automated employment recruiting and screening system for temporary professional employees: A case study
Authors: Buckley Patrick , Minette Kathleen , Joy Dennis , Michaels Jeff 
Published: August 2004

AbstractMany human resource systems are presently being modified so they can be administered using various forms of computer technology. These technological advances are being driven primarily by strong demands from human resource professionals for enhancements in speed, effectiveness, and cost containment. This case study presents results obtained by an educational publisher from use of an automated recruiting and screening system. The system allowed for recruiting and the automated administration of professionally developed, job‐related questions aimed at deciphering whether an applicant meets the job requirements. The analyses showed conservative savings due to reduced employee turnover, reduced staffing costs, and increased hiring‐process efficiencies. These cumulative savings yielded a return on investment of 6.0 to 1, or a return of $6.00 for every $1.00 invested in the program. When these savings were adjusted to reflect increased hiring trends, more pronounced savings were evident. The current system coupled with the addition of planned enhancements should increase future hiring efficiency, employee quality, and resulting financial savings. © 2004 Wiley Periodicals, Inc.
Work‐nonwork conflict and job stress among virtual workers
Authors: Raghuram Sumita , Wiesenfeld Batia 
Published: August 2004

AbstractA primary objective of organizational virtual work programs (e.g., providing the option to employees to work from home) is the reduction of employees'work‐nonwork conflict and job stress. In this study, we find some preliminary evidence suggesting that virtual work is negatively related to work‐nonwork conflict and job stress. We identify the work factors (clarity of appraisal criteria, interpersonal trust, and organizational connectedness) and individual factors (self‐efficacy and ability to structure the workday) associated with work‐nonwork conflict and find that these associations are moderated by the extent of virtual work. © 2004 Wiley Periodicals, Inc.
Supraglottic and glottic carcinomas: Epidemiologically distinct entities?
Authors: De Stefani Eduardo , Boffetta Paolo , Deneo‐Pellegrini Hugo , Brennan Paul , Correa Pelayo , Oreggia Fernando , Ronco Alvaro L. , Mendilaharsu María 
Published: August 2004

AbstractIn the time period 1988–2000, a case‐control study on laryngeal cancer was conducted in Montevideo, Uruguay. Four‐hundred eighty‐one (481) cases newly diagnosed and microscopically confirmed as squamous cell carcinomas were included. These cases were frequency matched with 481 nonneoplastic controls, admitted to the same hospitals as the cases. The purpose of our study was to compare odds ratios (ORs) by laryngeal subsite (supraglottis and glottis). ORs of supraglottic cancers displayed much higher risks than glottic carcinomas for most tobacco variables and for red wine intake. The differences between subsites were statistically significant, displaying heterogeneity between both subsites. Moreover, whereas black tobacco smokers displayed a significant increased risk of 1.7 (95% confidence interval [CI] 1.2–2.5) compared to smokers of blond (flue‐cured) tobacco among supraglottic tumors, no effect of this type of tobacco was observed in glottic lesions. It could be suggested that concerning tobacco and alcohol effects, supraglottic and glottic squamous cell cancers are probably distinct epidemiologic entities. © 2004 Wiley‐Liss, Inc.
Calcitriol‐induced prostate‐derived factor: Autocrine control of prostate cancer cell growth
Authors: Nazarova Nadja , Qiao Shengjun , Golovko Olga , Lou Yan‐Ru , Tuohimaa Pentti 
Published: August 2004

AbstractCalcitriol (1α,25‐dihydroxycholecalciferol) seems to play an important role in the complex control of prostate cell growth. It inhibits proliferation and induces differentiation and apoptosis in prostate cancer cells. However, the molecular mechanisms of the antiproliferative activity of calcitriol are not completely understood. The expression of prostate‐derived factor (PDF), a member of the transforming growth factor‐β (TGF‐β) superfamily, has been shown to be associated with proapoptotic and antimitotic activities. We show that calcitriol induces PDF expression in LNCaP human prostate cancer cells in a concentration‐ and time‐dependent manner. In LNCaP cells, the suppression of cell growth by calcitriol is accompanied by stimulation of PDF mRNA and protein synthesis. Human recombinant PDF inhibits LNCaP cell growth. We do not detect any effect of PDF‐specific antibody on the basal growth of LNCaP cells, but this antibody partially reverses the suppression of LNCaP cell growth by calcitriol, suggesting that the effect of calcitriol on cell growth is at least partially mediated by PDF. In PC‐3 cells, which are less responsive to the growth‐inhibitory effect of calcitriol, it has no effect on PDF expression. We do not detect an effect of recombinant PDF on SMAD phosphorylation in LNCaP cells, but ERK1/2 kinases are transiently phosphorylated in response to PDF, which suggests that in LNCaP cells PDF may exert its action through pathway alternative to the classical TGF‐β signaling pathway. The present study describes the regulation of PDF, the proapoptotic protein of the TGF‐β superfamily, by calcitriol in androgen‐responsive prostate cancer cells. This is a new link between calcitriol and growth factors of TGF‐β superfamily in the control of prostate cell growth. © 2004 Wiley‐Liss, Inc.