bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐concept in adult survivors of childhood acute lymphoblastic leukemia: A Cooperative Children's Cancer Group and National Institutes of Health Study
Authors: Seitzman Robin L. , Glover Dorie A. , Meadows Anna T. , Mills James L. , Nicholson H. Stacy , Robison Leslie L. , Byrne Julianne , Zeltzer Lonnie K. 
Published: January 2004

AbstractBackgroundSelf‐concept was compared between adult survivors of childhood acute lymphoblastic leukemia (ALL) and sibling controls. Adult survivor subgroups at greatest risk for negative self‐concept were identified.ProcedureSurvivors (n = 578) aged ≥18 years, treated before age 20 years on Children's Cancer Group (CCG) ALL protocols, and 396 sibling controls completed a telephone interview and the Harter Adult Self‐Perception Profile (ASPP).ResultsSurvivors global self‐worth scores were significantly lower than sibling controls (mean 3.09 vs. 3.18; P = 0.022). Unemployed survivors reported lower global self‐worth scores than employed (mean 2.77 vs. 3.12; P = 0.0001), whereas employment status was not associated with self‐worth in controls. Among survivors, predictors of negative self‐concept included unemployment (odds ratio (OR) = 2.87; 95% CI: 1.50–5.50), and believing that cancer treatment limited employability (OR = 3.17; 95% CI: 1.79–5.62). Unemployment increased the odds for negative self‐concept among survivors who received combinations of central nervous system (CNS) irradiation (CRT) and intrathecal methotrexate (IT‐MTX), except high CRT with no or low dose IT‐MTX. Employed survivors who perceived that treatment limited their employability showed increased odds of negative self‐concept for all treatment groups compared to those who did not. Minority ethnic group membership was a borderline significant predictor of negative self‐concept (OR = 1.79; 95% CI: 0.94–3.33).ConclusionsGlobal self‐worth was significantly lower in ALL survivors than sibling controls, however, 81% of survivors had positive self‐concept. Survivor subgroups most vulnerable to negative self‐concept were the unemployed survivors, believing that cancer treatment affected employability, and ethnic minority group members. Targeted intervention may have greater clinical relevance for these subgroups. © 2003 Wiley‐Liss, Inc.
Caring for a child with cancer—A systematic review
Authors: Vance Yvonne , Eiser Christine 
Published: January 2004

AbstractObjectiveTo report the results of a systematic review to determine the effects of parents' behavior on children's coping with cancer.MethodsSearches were conducted using Medline, EMBASE, PsycLit, and articles were subsequently selected on the basis of predefined criteria.ResultsTwenty‐four papers were identified. There were associations between parenting behaviors and child distress both before and during medical procedures. Parents who criticized the child, or apologized for what was happening had children who were more distressed. Parents who were very permissive had more problems with adherence to treatment regimens.ConclusionsParents' behavior is critical in determining children's responses during procedures and adherence to home care. There has been less work concerning how parents manage more everyday problems, such as encouraging the child to go to school. Longitudinal studies are recommended to determine how parenting behaviors affect longer term child adjustment. These findings may be helpful for clinic staff to understand parents' reactions, and may also inform the content of intervention programs. © 2003 Wiley‐Liss, Inc.
Association of cytogenetic abnormalities with detection of BCR‐ABL fusion transcripts in children with T‐lineage lymphoproliferative diseases (T‐ALL and T‐NHL)
Authors: Lo Nigro Luca , Sainati Laura , Mirabile Elena , Lanciotti Marina , Poli Amelia , Leszl Anna , Basso Giuseppe 
Published: January 2004

AbstractDetection of Philadelphia chromosome (Ph) in childhood T‐lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T‐ALL and T‐NHL) presenting with both cytogenetic alterations and BCR‐ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi‐lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T‐cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR‐ABL fusion transcript. © 2003 Wiley‐Liss, Inc.
Biodistribution of post‐therapeutic versus diagnostic 131I‐MIBG scans in children with neuroblastoma
Authors: Hickeson Marc P. , Charron Martin , Maris John M. , Brophy Patricia , Kang Tammy I. , Zhuang Hongming , Khan Jehanzeb , Nevrotski Teresa 
Published: January 2004

AbstractBackgroundTo evaluate the biodistribution of therapeutic 131I‐metaiodobenzylguanidine (MIBG) and assess the sensitivity of diagnostic versus therapeutic 131I‐MIBG scans to detect metastatic disease.ProcedureThis retrospective study included 44 diagnostic and post‐therapy scans (PTS) in 18 children with neuroblastoma treated with 131I‐MIBG (2.0–33.1 GBq). The findings of diagnostic scans (DS) (2.6–44.4 MBq) were compared to those of corresponding PTS.ResultsIn terms of biodistribution, the PTS identified 131I‐MIBG activity in one or more patients in the following regions not detected on the DS: nasal mucosa, cerebellum, central brain, adrenals, spleen, kidneys, thyroid, salivary glands, lower halves of the lungs, bladder, bowel, and an incisional scar. Conversely, the DS identified activity in the thorax, heart, kidneys, and bladder each in one patient without being visualized on the PTS. In terms of sensitivity to detect metastatic disease, 210 lesions were seen on the PTS compared to 151 on the DS. The PTS demonstrated sites of disease not evident in the DS in 16 cases.ConclusionsThe biodistribution of 131I‐MIBG is different using therapeutic doses as compared to pre‐therapy doses. 131I‐MIBG imaging following high therapeutic doses often reveals sites of occult metastatic disease that may be clinically relevant. © 2003 Wiley‐Liss, Inc.
Middle cerebral artery Doppler velocimetric assessment in two cases of hydrops fetalis without fetal anaemia
Authors: Shah Neil K. , Martin William L. , Whittle Martin J. 
Published: January 2004

AbstractObjectivesRaised middle cerebral artery (MCA) Doppler velocity has been shown to be highly predictive of moderate to severe fetal anaemia. We present two false‐positive cases of raised MCA Doppler velocity in non‐immune hydropic fetuses.MethodsIn both cases, routine investigations for fetal hydrops, as well as detailed ultrasound scanning and MCA peak‐systolic velocity Doppler assessment (maximum velocity taken at zero degrees to the vessel), were performed. Fetal blood sampling was carried out at the same visit.ResultsMCA peak‐systolic velocity values greater than 1.50 MoM for gestation were found in both cases. However, both fetuses had normal haemoglobin values and haematocrits. Both fetuses died in utero soon after diagnosis.ConclusionsA raised MCA velocity in a hydropic fetus may not always be due to fetal anaemia, rather it may indicate a fetus in poor condition perhaps due to cardiovascular decompensation and redistribution of blood to the fetal brain. Copyright © 2003 John Wiley & Sons, Ltd.
Prenatal diagnosis of premature centromere division–related mosaic variegated aneuploidy
Authors: Chen Chih‐Ping , Lee Chen‐Chi , Chen Wen‐Lin , Wang Wayseen , Tzen Chin‐Yuan 
Published: January 2004

AbstractObjectivesTo present the prenatal diagnosis of premature centromere division (PCD)‐related mosaic variegated aneuploidy (MVA) and a review of the literature.Case and MethodsA 33‐year‐old primigravida woman underwent amniocentesis at 22 weeks' gestation because of intrauterine growth restriction (IUGR), microcephaly, and oligohydramnios. Amniocentesis revealed PCD‐related MVA. Repeat amniocentesis two weeks later consistently showed PCD‐related MVA. The pregnancy was terminated. The proband postnatally manifested dysmorphic facial features of microcephaly, hypertelorism, low‐set ears, a broad nasal bridge, a thin upper lip, and overriding toes. At autopsy, the internal organs were unremarkable. Cytogenetic analyses of the cord blood, liver, lungs, skin, and placenta displayed PCD‐related MVA in all tissues studied. The PCD frequencies for the cells in the amniotic fluid (first culture), amniotic fluid (second culture), cord blood, liver, lungs, skin, and placenta were 53.3%, 56.5%, 47.4%, 38.7%, 33.9%, 33.3%, and 40.8% respectively.ConclusionThe present case provides evidence that, in cases of pregnancy with PCD‐related MVA, the cytogenetic result of the amniocytes correlates well with those of the fetal cells and chorionic villi cells. We suggest that prenatal sonographic detection of a complex of IUGR, microcephaly and oligohydramnios with or without central nervous system abnormalities should include a differential diagnosis of PCD‐related MVA. Copyright © 2003 John Wiley & Sons, Ltd.
Multi‐channel magnetocardiography for detecting beat morphology variations in fetal arrhythmias
Authors: Sturm R. , Müller H.‐P. , Pasquarelli A. , Demelis M. , Erné S. N. , Terinde R. , Lang D. 
Published: January 2004

AbstractObjectiveOver the last few years, a number of studies have shown that fetal magnetocardiography (fMCG) is useful in describing fetal cardiac activity. A 55‐channel MCG system in Ulm was used to record fetal cardiac activity in 12 pregnant women (with normal fetal heart activity in echocardiography) and in 5 pregnant women in whom the echocardiography showed fetal arrhythmias.MethodThe recorded MCG data were treated in order to eliminate the maternal signal and three MCG channels with the best signals were used to emulate a standard electrocardiogram (ECG) recording so that standard MCG analysis could be performed.ResultsThe results in assessing fetal electrophysiology, demonstrating its potential, are presented here for two fetuses with recorded supraventricular extrasystoles (SVES) and for one with ventricular extrasystoles (VES). Concerning the SVES, the analysis software OMEGA was able to separate three different beat morphologies. The VES could be detected exactly and have been confirmed by postnatal ECG.ConclusionThe beat morphology and the beat‐to‐beat variations allow new insights into the electrophysiology of the fetal heart. Copyright © 2003 John Wiley & Sons, Ltd.
The prenatal diagnosis of cloacal dysgenesis sequence in six cases: can the termination of pregnancy always be the first choice?
Authors: Sahinoglu Zeki , Mulayim Baris , Ozden Selcuk , Etker Seref , Celayir Aysenur , Ozkan Ferda , Bilgic Remziye 
Published: January 2004

AbstractObjectiveCloacal dysgenesis sequence is a lethal malformation, which usually requires termination. In this study, our aim was to evaluate the prenatal and postnatal diagnostic features of cloacal dysgenesis sequence and review the management of the patients.Material and MethodsThe data of six cases of cloacal dysgenesis sequences were collected from the ultrasonography and neonatal records. The findings were evaluated in prenatal and postnatal periods. Chromosomal analysis was performed in all the cases. The evaluation of primary and secondary malformations was done. Coexisting anomalies were searched for by radiology and histopathology.ResultsMalformations in six cases (two females and four males) were described. The absence of anal, genital, and urinary openings with intact perineum covered by smooth skin were common findings. These features were considered as primary malformations for cloacal dysgenesis sequence. Secondary anomalies (urinary and gastrointestinal system malformations, pulmonary hypoplasia, and other coexisting anomalies) were evaluated.ConclusionThe prenatal differential diagnosis of cloacal dysgenesis sequence from other urinary obstructive diseases was essential regarding fetal prognosis, prenatal, and neonatal management. The bladder outlet obstruction and pulmonary hypoplasia due to reduced amniotic fluid and/or kidney disease were considered prognostic factors for neonatal death. Termination of pregnancy is almost always recommended instead of intrauterine shunt procedures; but if we take into consideration one of our cases and a few reported cases who survived in the neonatal period, the prenatal management of these pregnancies needs to be reevaluated. Copyright © 2003 John Wiley & Sons, Ltd.
Second‐trimester diagnosis of intracranial vascular anomalies in a fetus with subdural hemorrhage
Authors: Strigini Francesca A. L. , Nardini Vincenzo , Carmignani Arianna , Valleriani Anna Maria 
Published: January 2004

AbstractObjectivesRisk factors for intracranial hemorrhage occurring in prenatal life are imperfectly known. A case of prenatal diagnosis of subdural hemorrhage associated with multiple intracranial vascular aneurysms is described.MethodsSonography and magnetic resonance imaging of the fetal head were obtained at 21 weeks' gestation and compared with pathologic findings.ResultsSonography showed a large transonic mass displacing the normal intracranial structures. Magnetic resonance imaging demonstrated the hemorrhagic origin of the mass and showed multiple vascular anomalies. Postmortem examination confirmed the compression of the cerebral hemisphere by a blood collection, probably because of bleeding from one of the multiple vascular aneurysms into the subdural space.ConclusionMagnetic resonance imaging with the use of single‐shot ultrafast sequences may be useful not only in the differential diagnosis of fetal intracranial hemorrhage but also in identifying vascular risk factors. Copyright © 2003 John Wiley & Sons, Ltd.
Follow‐up of children with isolated fetal echogenic bowel with particular reference to bowel‐related symptoms
Authors: Patel Y. , Boyd P. A. , Chamberlain P. , Lakhoo K. 
Published: January 2004

AbstractObjectivesTo determine whether there was any evidence of long‐term bowel pathology in children, apparently healthy at birth, who had a prenatal second‐trimester diagnosis of isolated grade 2 fetal echogenic bowel.MethodsThis was a retrospective study using data from the Oxford Congenital Anomaly Register. Fetuses with isolated grade 2 fetal echogenic bowel and date of delivery from 1994 to 2000 inclusive were identified. Information about the health of the children, particularly relating to bowel symptoms, was obtained from hospital records and from a questionnaire sent to the general practitioner.ResultsA total of 109 cases were identified, with delivery details available for 108. There was one unexplained intrauterine death, and additional problems were subsequently diagnosed in four cases (cystic fibrosis (2), Down syndrome (1), and VACTERL (1)). Questionnaires were sent to the GPs of the 103 who had no problems identified at the time of discharge from the maternity hospital. Age at follow‐up ranged from one to four years. Responses to the questionnaires were received from 83 (81%). Of these, 74 (89%) had not reported bowel symptoms to the GP, 9 (11%) reported symptoms relating to constipation (6), chronic abdominal pain (1), infantile colic with milk intolerance (1) and gastro‐oesophageal reflux (1).ConclusionThis small study provides some reassurance that there was no evidence of any serious long‐term bowel pathology associated with isolated fetal echogenic bowel. Copyright © 2003 John Wiley & Sons, Ltd.
Clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 4
Authors: Chen Chih‐Ping , Chern Schu‐Rern , Lee Chen‐Chi , Chang Tung‐Yao , Wang Wayseen , Tzen Chin‐Yuan 
Published: January 2004

AbstractObjectivesTo present the clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 4.CaseAn amniocentesis was performed at 21 weeks' gestation because of maternal anxiety. Cytogenetic analysis revealed mosaicism for trisomy 4, 47,XX,+4[4]/46,XX[16]. Level II ultrasound demonstrated tetralogy of Fallot. Repeated amniocentesis at 23 weeks' gestation revealed 47,XX,+4[4]/46,XX[19]. The pregnancy was terminated. Phenotypic findings included tetralogy of Fallot, hypertelorism, micrognathia, abnormal ears, duplicated phalanges of the left thumb, clinodactyly, and overlapping of the toes. The karyotype of the cord blood was 46,XX. Cytogenetic analyses of the multiple tissue samplings showed a karyotype of 47,XX,+4 in 40/40 cells of the amniotic membrane (amnion), and 47,XX,+4/46,XX with various levels of trisomy 4 in the cells of the liver, lungs, placenta, skin, and umbilical cord. The levels of trisomy 4 were 11/40 in the liver, 8/40 in the lungs, 31/40 in the placenta, 9/40 in the skin, and 8/40 in the umbilical cord.MethodThe parental origin and meiotic origin of trisomy 4 were determined by examining the amniotic membrane using quantitative fluorescent polymerase chain reaction assays with polymorphic markers specific for chromosome 4. The result was consistent with a paternal meiosis I nondisjunction error. The cord blood showed a biparental inheritance. An extra paternal heterozygous allele with partial dosage increase was noted in other fetal and extraembryonic tissues studied.ConclusionA diagnosis of trisomy 4 mosaicism in amniocytes indicates an increased risk for fetal abnormalities. Associated abnormal findings include congenital heart defects and anomalies of the digits and thumb. A confirmatory placental sampling may be helpful, whereas a fetal blood sampling is of a very limited value. A postnatal amnion sampling may provide additional clues to the fetal involvement of trisomy 4. Copyright © 2004 John Wiley & Sons, Ltd.
Interleukin‐8 mRNA in vaginal secretions: a prenatal marker of congenital infection in case of preterm labor with intact membranes
Authors: Kayem G. , Maillard F. , Batteux F. , Weill B. , Cabrol D. , Goffinet F. 
Published: January 2004

AbstractObjectiveTo study whether interleukin‐8 (IL‐8) mRNA in vaginal secretions is associated with congenital infection and preterm delivery in the case of preterm labor with intact membranes.MethodsThis prospective clinical study in a tertiary referral center included 280 patients who gave birth to 360 infants from 1997 through 1999. IL‐8 mRNA in vaginal secretions was determined with reverse transcriptase polymerase chain reaction. Logistic regression was used to examine the association between vaginal IL‐8 mRNA and congenital infection independently of the time of birth. Main outcome measures were congenital infection and delivery before 37 and 33 weeks' gestation.ResultsA total of 100 women (100/280 (35.7%)) gave birth before 37 weeks. A total of 54 children (54/360 (15%)) had congenital infection. IL‐8 mRNA in vaginal secretions was associated with delivery within 14 days of the sampling (24 (15.6%) vs. 7 (5.6%) p < 0.01), but not with delivery within 48 h, 7 days (p = 0.07) or before 37 or 33 weeks. There were more congenital infections in the group with detectable IL‐8 mRNA (37 (19.3%) than in the negative group (17 (10.1%); p < 0.05). IL‐8 mRNA was associated with congenital infection independently of the time of birth (OR: 2.6 (1.3–5.1)). This test had a sensitivity for predicting neonatal infection of 69%. Its specificity was 49%, its positive predictive value 19%, and its negative predictive value 90%.ConclusionIL‐8 mRNA could be a prenatal noninvasive vaginal marker of congenital infection. Copyright © 2004 John Wiley & Sons, Ltd.
Prenatal diagnosis of mosaic trisomy 16 associated with congenital diaphragmatic hernia and elevated maternal serum alpha‐fetoprotein and human chorionic gonadotrophin
Authors: Chen Chih‐Ping , Shih Jin‐Chung , Chern Schu‐Rern , Lee Chen‐Chi , Wang Wayseen 
Published: January 2004

AbstractObjectivesTo present the clinical, cytogenetic, and molecular findings of prenatally diagnosed mosaic trisomy 16.CaseA 30‐year‐old gravida 2, para 1 woman was referred for amniocentesis because of a positive maternal serum screen result with elevated maternal serum alpha‐fetoprotein (MSAFP) and maternal serum free β‐human chorionic gonadotrophin (MSfreeβ‐hCG). Cytogenetic analysis of amniotic fluid at 21 weeks' gestation revealed mosaicism for trisomy 16, 47,XX,+16[3]/46,XX[15]. Ultrasonography demonstrated right diaphragmatic hernia and agenesis of left umbilical artery. The pregnancy was terminated subsequently. The karyotype of the cord blood was 46,XX. Cytogenetic analyses of the multiple sampled tissue specimens showed a karyotype of 47,XX,+16 in the placenta and 47,XX,+16/46,XX with various levels of trisomy 16 in the umbilical cord and skin. Molecular studies showed that the trisomy 16 in the placenta was likely to have resulted from a maternal meiosis II nondisjunction error. Partial dosage increase of an extra maternal allele was noted in the skin and umbilical cord.ConclusionFetuses with mosaic trisomy 16 may be associated with congenital diaphragmatic hernia and elevated MSAFP and MShCG. Fetal blood sampling is of a limited value in confirming mosaic trisomy 16 ascertained through amniocentesis. Copyright © 2004 John Wiley & Sons, Ltd.
Interband transitions of wide‐band‐gap ternary pnictide BeCN2 in the chalcopyrite structure
Authors: Chiker F. , Abbar B. , Bouhafs B. , Ruterana P. 
Published: January 2004

AbstractEquilibrium lattice constants, bulk modulus, electronic band structure, and different optical transitions calculated by means of the full potential linearized augmented plane wave method are presented for BeCN2 in the chalcopyrite structure. Analysis of the band structure suggests a pseudo‐direct band gap, which refers to an indirect band gap in binary compounds. We also discuss the relationships of the principal band gaps of the c‐BN zinc‐blende analogs. We investigate the assignment of the different optical transitions that are discussed in more detail from the reflectivity spectra. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dynamics of localized Mn spins in diluted‐magnetic‐semiconductor nanostructures with quantum dots
Authors: Scherbakov A. V. , Akimov A. V. , Yakovlev D. R. , Ossau W. , Molenkamp L. W. , Terai Y. , Kuroda S. , Takita K. , Souma I. , Oka Y. 
Published: January 2004

AbstractDynamics of spin–lattice relaxation of the magnetic Mn‐ion system is investigated for nanostructures with (Cd,Mn)Te and (Cd,Mn)Se diluted‐magnetic‐semiconductor (DMS) quantum dots. A nonequilibrium phonon technique with optical detection of the induced heating of the magnetic ion system was exploited. A strongly nonexponential decay of the spin dynamics is found to be specific for the DMS quantum dots. It is explained in the frame of a model suggesting that the spin dynamics in quantum dots is strongly affected by a spin diffusion into/from a DMS wetting layer, where the spin–lattice relaxation rate differs from that in the quantum dots. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A new band in Cr3+‐doped MgAl2O4 natural spinel at room temperature
Authors: Phan The‐Long , Phan Manh‐Huong , Yu Seong‐Cho 
Published: January 2004

AbstractTime resolved photoluminescence spectra of natural MgAl2O4 spinel doped with Cr3+ ions have been investigated at room temperature in the wavelength range between 380 and 800 nm. Using several excitation sources from the different lasers we have observed a new band, namely K, with a peak of 15,547 cm−1 (643.2 nm) and the transition process of photoluminescent lines among the electronic levels of the Cr3+ ion. In terms of the experimental results and the Tanabe‐Sugano diagram, we strongly propose that the K‐band originates from the electric dipole transition, 2Eg → 4A2g in the strong crystal field with Dq/B > 2.3. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)