bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological Rigor and Quality of Reporting of Clinical Trials Published with Physical Activity Interventions: A Report from the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative)
Authors: Ignacio Andresa Conrado , Oliveira Nórton Luís , Silva Larissa Xavier Neves da , Leite Jayne Santos , De Nardi Angélica Trevisan , Helal Lucas , Santos Marcelo Rodrigues dos , Soares Douglas dos Santos , Galliano Leony Morgana , Alano Tainá Silveira , Umpierre Daniel 
Published: October 2023

Abstract
Background
In response to the growing number of published randomized clinical trials (RCTs), efforts have been made to promote transparent and reproducible research practices. However, limited evidence exists to demonstrate the level of adherence to established reporting and methodological standards. This study aimed to evaluate the methodological standards and quality of reporting in RCTs of physical activity (PA) interventions. We aimed to present Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative) 2020 assessments results.
Methods
RCTs of PA advice or exercise interventions published in 2020 were selected. Monthly searches were conducted on PubMed/MEDLINE targeting six top-tier exercise science journals. Assessments were conducted by two independent authors, based on 44 items originally from CONSORT and TIDieR reporting guidelines. These items were divided into seven domains: transparency, completeness, participants, intervention, rigor methodology, outcomes and critical analysis. Descriptive analysis was performed using absolute and relative frequencies, and exploratory analysis was done by comparing proportions using the X2^test (α = 0.05).
Results
Out of 1,766 RCTs evaluated for eligibility, 53 were included. The median adherence to recommended items included among the studies was 30, ranging from 18 (41%) to 44 (100%) items in individual study assessments. The items presenting full adherence among the studies were related to intervention description, justification, outcome measurement, effect sizes, and statistical analysis. The least reported item referred to mentioning unplanned modifications during trials, appearing in 6 (11.3%) studies. Out of the 53 RCTs, 36 (67.9%) reported having a registration, and these studies demonstrated higher adherence to the assessed items compared to non-registered studies.
Conclusions
In general, items related to critical analysis were more thoroughly described, such as hypotheses and statistical analyses. However, aspects more related to transparency aspects, such as protocol registrations/modifications and intervention descriptions, were suboptimally reported. Finally, this study highlights the need to promote the existing resources concerning quality of reporting and transparent research practices for investigators and editors in the exercise sciences discipline.
On-surface synthesis and characterization of anti-aromatic cyclo[20]carbon
Authors: Xu Wei , Sun Luye , Zheng Wei , Kang Faming 
Published: October 2023

Abstract
Molecular carbon allotropes, cyclo[n]carbons (Cn) have attracted significant attention from both experimentalists and theoreticians due to their extraordinary properties1-9. Nevertheless, their synthesis in condensed phase is hardly achieved due to the high reactivity, resulting in the geometric and electronic structures of these species remaining largely unexplored. Recently, on-surface synthesis has emerged as an efficient method for the fabrication of various cyclocarbons, including C1810,11, C1612, C1413, C1013. However, endeavors to synthesize larger cyclocarbons (e.g., C20 or C24) have encountered difficulties owing to the unstability of precursor molecules12. Herein, we design a molecular precursor of a fully halogenated dibenzo[b,h]biphenylene (C20Cl12), and successfully produce the anti-aromatic cyclo[20]carbon (C20), via tip-induced dehalogenation and accompanied ring-opening reactions on a bilayer NaCl/Au(111) surface at 4.7 kelvin. The polyynic structure of C20 was revealed by bond-resolved atomic force microscopy (AFM) and theoretical calculations. Furthermore, by subtly positioning the C20 molecule into an “atomic fence” (i.e., formed by Cl atoms) to block its diffusion, we have achieved to experimentally probe the frontier molecular orbitals of C20, with a measured bandgap of 3.8 eV. Our work demonstrates the versatility of such an on-surface synthesis strategy for the generation of cyclocarbons in the condensed phase, and for further characterizing their precise geometric and electronic structures.
Multiplicity results for some quasilinear elliptic problems with concave nonlinearities
Authors: Pei Ruichang 
Published: October 2023

Abstract

The purpose of this paper is to investigate the existence of five nontrivial solutions and the existence of infinitely many nontrivial solutions for a class of (p, 2)-Laplacian equations with subcritical polynomial growth and subcritical (critical) exponential growth. Some existence results for nontrivial solutions are established by using the variational methods.
Прогностическое значение соматических мутаций в генах эпигенетической регуляции при острых миелоидных лейкозах в реальной клинической практике: результаты наблюдательного неинтервенционного проспективного межрегионального исследования
Authors: Шатилова Алексина Алексеевна , Будаева И. Г. , Петухов А. В. , Силонов С. А. , Ершова А. Е. , Никулина Т. С. , Матвиенко Ю. Д. , Миролюбова Ю. В. , Богданов К. В. , Анчукова Л. В. , Нередько Ю. С. , Тяско С. Ю. , Очирова О. Е. , Карпова А. Г. , Васильева Э. Р. , Сердюк О. Д. , Яскульский Д. А. , Букин Д. В. , Алексеева Ю. А. , Ломаиа Е. Г. , Гиршова Л. Л. 
Published: October 2023

Aim. To assess the rate of DNMT3A, IDH1, IDH2, and ASXL1 gene mutations and their effect on the prognosis both as isolated findings and in combination with well-known chromosomal aberrations and gene mutations in newly diagnosed acute myeloid leukemia (AML) patients from some regions of the Russian Federation.
Materials & Methods. The study enrolled 83 patients with newly diagnosed AML from 22 regions of the Russian Federation, who underwent molecular genetic examination for detecting IDH1 (R132), IDH2 (R140), ASXL1, and DNMT3A gene mutations with droplet digital PCR and Sanger sequencing methods.
Results. The mutation rate in DNMT3A was 16.7 %, in IDH1 (R132) it was 6 %, in IDH2 (R140) it was 9.6 %, and in ASXL1 it was 6 %. The R140 mutation in IDH2 correlated with the older age of patients. The mutations in IDH1 (R132), IDH2 (R140), and DNMT3A showed a significant association with mutated NPM1. The mutations in IDH1 (R132), IDH2 (R140) were reported to occur significantly more often in patients with normal karyotype. The IDH1 (R132) and IDH2 (R140) mutations appeared to have a favorable effect on AML prognosis, which is most likely to be associated with a high rate of their compatibility with NPM1 mutation. The mutated type of DNMT3A had a negative effect on overall survival of patients with NPM1 mutation. The mutation in ASXL1 also appeared to be an unfavorable prognostic factor for overall survival of patients with wild type NPM1.
Conclusion. A high rate of mutation occurrence in epigenetic regulation genes as well as the prognostic potential of these mutations in AML necessitate the need for determining the mutation status of DNMT3A, IDH1, IDH2, and ASXL1 in the context of primary diagnosis in real-world clinical practice.
Innovating superparamagnetic chitosan hybrid nanoparticles for a high-efficiency separation of oil from oil–water emulsions
Authors: Bairagi Anup Kumar , Mohapatra Soumya Sanjeeb , Sahoo Abanti , Tembhurne Saurabh Chokhoba 
Published: October 2023

Abstract

In an era marked by rapid industrialization and heightened automobile usage, the demand for crude oil has surged, inducing ecological degradation and resource depletion. Effective management of intricate oily wastewater presents a formidable challenge. While diverse methods like gravity separation, centrifugation, and membrane techniques are employed for oil-water separation, gravity separation is the prevailing choice, yet limited to unstable emulsions. These methods often involve toxic substances harmful to marine life. Our research focuses on separating oil microemulsions in aqueous solutions. This study explores the application of superparamagnetic chitosan coagulants, revealing an optimal 10 ml dosage for peak efficiency. Aiming for rapid oil separation, we achieved a breakthrough with just 30 minutes, establishing a new benchmark. Rigorous VSM testing solidified the particles' magnetic capabilities, augmented through size reduction. Notably, at a 15% oil concentration, a remarkable 99.26% efficiency in oil separation was achieved, offering potential in microbiology, medicine, and drug delivery systems.
Hydrogeologic characteristics of groundwater in the Kızılırmak graben (Nevşehir–Turkey) and its evaluation in terms of irrigation water quality
Authors: Demircioğlu Ramazan , Dursun Yusuf Gökhan , Demircioğlu İlknur 
Published: October 2023

Abstract

In this study, an area of 150 km2 with important settlements and agricultural areas within the Kızılırmak and Kuyulukışla grabens, in the north of Nevşehir province (Turkey), was investigated. This study aimed to evaluate the hydrochemical properties and water quality of the vital groundwater in the study area, determine effective utilisation methods, and make recommendations for sustainable use. From the data obtained as a result of these analyses, sodium adsorption ratio (SAR) and sodium percentage (%Na) values were calculated and compared with WHO (World Health Organization) and TS-266 (Turkish Standards) quality standards to determine the characteristics of water for human consumption and irrigation for agricultural purposes. Based on these values, Wilcox diagrams and US Salinity Laboratory diagrams were used. According to these evaluations, it was found that sample SMP1 is not suitable for use as drinking water according to the basic parameters in the reference standards, while the other samples are suitable for drinking and human consumption. Electrical conductivity, %Na, SAR values, US Salinity Laboratory, and Wilcox diagrams were used to evaluate the use of water resources for irrigation purposes. According to the results obtained, all samples except sample SMP1 were found to be suitable for use as irrigation water.
Vermicomposting as an effective approach to municipal sewage sludge management through optimization of the selected process variables
Authors: Banda Beauty , Habtu Nigus Gabbiye , Gebreeyessus Getachew Dagnew , Meshesha Beteley Tekola 
Published: October 2023

AbstractIn most developing countries, municipal sewage sludge end-use practices appear unsustainable; rather, it poses environmental concerns. This study examined the potential of vermicomposting of municipal sewage sludge and its blend with other biowaste for agricultural application. Using a response surface methodology and the Box–Behnken design in Design Expert Software (Version 10.0.7), the current study optimized the moisture content (60–90%), turning frequency (1–3 turnings/week), and substrate mixing ratios (50:50 to 80:20 wt.%) to maximize the content of nitrogen, phosphorus, and potassium. As a result, an optimal moisture content (72%), substrate mixing ratio (72.34:27.6 wt.%), and turning frequency (2 per week), producing a promising-quality vermicompost with a maximum yield of nitrogen (2.76%), phosphorus (1.80%), and potassium (1.88%) is achieved. Thus, vermicomposting can effectively turn the concerning municipal sewage sludge into useful agricultural input for its sustainable management.
Efecto de los lineamientos de la OCDE respecto a la tributación de dividendos en el Ecuador
Authors: Sánchez Moreno Stefany , Córdova Naranjo Mentor , Sánchez Lindao Julio , Arcos Escobar Nelson 
Published: October 2023

El presente artículo se enfoca en el tratamiento tributario a distribución de dividendos contemplado en el marco legal tributario ecuatoriano. La metodología aplicada corresponde al enfoque cualitativo con la modalidad de investigación documental, por lo que, se compararon las recomendaciones del Informe de la Acción 2 del modelo BEPS (del inglés: Base Erosion and Profit Shifting y del español: Erosión de la Base Imponible y traslado de beneficios) y su aplicación en la normativa ecuatoriana. Este artículo surge de la percepción de la inestabilidad jurídica generada por la normativa tributaria ecuatoriana debido a la modificación constante del tratamiento a la renta de dividendos al momento de someterla a imposición. Para el presente artículo se analizaron datos de la Administración Tributaria, respecto a rubros declarados por los contribuyentes en los Formularios de Retenciones en la Fuente de Impuesto a la Renta y Formulario de Impuesto a la Renta de los ejercicios fiscales 2017 al 2020 por dividendos, y se evaluó el nivel de percepción a expertos en fiscalidad internacional, con lo cual permitió concluir que, la normativa ecuatoriana ha aplicado parcialmente las reglas secundarias planteadas por la Acción 2 del modelo BEPS, debido a que su legislación interna mantiene el criterio de fuente y de residencia, o también denominado sistema de renta mundial.
Penile skin microbiota / microbiome in healthy men and some diseases
Authors: Naboka Yu. L. , Kotieva E. M. , Kotieva V. M. , Kogan M. I. 
Published: October 2023

The study of the cutaneous microbiota/microbiome of the male genital is relevant not only to understand "normality" for this biotope but also to correctly interpret the results obtained from patients with infectious-inflammatory diseases or postoperative infectious-inflammatory complications of penile skin. The study aimed to generalize and critically analyze data on microbial contamination of various areas of the penile skin by conducting a systematic review of publications. The search led to the selection of eight articles published in 2011 ­– 2023 that investigated the microbiota / microbiome features of the penile skin in health and some diseases. Thus, in sexually active healthy men, the penile skin microbiota / microbiome partly reflects the vaginal microbiome of sexual partners. After unprotected sexual contact, the frequency of detection and the number of Lactobacillus increase in the penile skin microbiota. In general, Corynebacteriaceae dominate on the penile skin, while Prevotellaceae, nc Clostridiales, Porphyromonadaceae, Staphylococcaceae, Bifidobacteriaceae, Lactobacillaceae, Veillonellaceae, Anaerococcus are less frequently recorded. Circumcision has a significant effect on the bacterial diversity of the penile skin. Although data regarding the penile skin microbiota/microbiome in various diseases are scarce, certain interactions have been noted. Thus, in healthy sexually active male partners of women with bacterial vaginosis, the number of bacteria associated with bacterial vaginosis increases and Corynebacterium decreases. In HIV-positive men, Staphylococcus, Faecalibacterium, Strenotrophominas, Jonquetella, Ruminococcus, Roseburia, Pseudochrobactrum and Lamia predominate on the penis skin. It is also noted that circumcision reduces the risk of HPV and HIV infections. Knowledge of not only the bacterial, but also fungal diversity of the penile skin microbiota is of great clinical importance, because conditionally pathogenic yeast-like fungi under certain conditions can cause a few diseases. Thus, this review analyses the microbial composition of penile skin in normal and some diseases, revealing a great gap in current knowledge of penile skin microbial assemblages. Studies are needed to better understand the microbial composition of normal penile skin and its impact on the results of reconstructive and plastic surgeries using penile skin.
Clip migration after minimally-invasive surgical procedures
Authors: Kotov S. V. , Guspanov R. I. , Zhuravleva A. K. 
Published: October 2023

Introduction. Today absorbable suture material as well as plastic nonabsorbable clips are widely used for surgical haemostasis and stabilisation of sutures during minimally invasive operations, however, they are capable of potential and spontaneous migration into the lower and upper urinary tract.Objective. In this paper, we present clinical cases of clip migration after radical prostatectomy and renal resection.Clinical cases. Clinical cases of spontaneous clip migration after the two most common minimally invasive interventions: kidney resection with subsequent removal of a foreign body after the use of lithokinetic therapy and a case of hemostatic material migration after robot-assisted radical prostatectomy. The literature review is also available.Conclusion. Excessive use of non-absorbable plastic clips around their close contact with the kidney cavity or the bladder wall should be avoided to achieve adequate hemostasis during minimally invasive methods of treating patients.
Gender-related differences and its effects on ureteroscopy success
Authors: Kotov S. V. , Nemenov A. A. , Perov R. A. , Sokolov N. M. 
Published: October 2023

Introduction. The prevalence of urinary stone disease (USD) historically considered a predominantly male disease. It has been rising over the last several decades with the rate of increase being higher among females. However, factors such as stone localisation, size, and density are usually analysed in postureteroscopic complications, and reports on gender-specific differences in the treatment of USD are scarce.Objective. To investigate the impact of gender differences on treatment success, intraoperative and postoperative complications in patients undergoing ureteroscopy.Materials & methods. A total of 300 patients with USD, who were performed ureteroscopic interventions in the period from September 2021 to November 2022 in Yudin City Clinical Hospital. Depending on gender, patients were divided into two groups — 194 (64.7%) men and 106 (35.3%) women. Recurrent USD was observed in 71 (36.6%) cases in Group I and in 45 (42.5%) cases in Group II, with an average recurrence time of 4.3 and 6.3 years, respectively. Male and female patients have had stone location in the upper third in 14.4% and 18.9% of cases, in the middle third in 18% and 6.6% (p = 0.005), in the lower third in 36 .1% and 49.1% (p = 0.04), in the intramural ureter in 28.9% and 21.7%, and in several localisations in 2.6% and 3.8% of cases, respectively.Results. The duration of surgery did not differ in both groups and composed 41.6 minutes. Internal ureteral stent placement was in 37 (19.1%) male patients and in 14 (13.2%) female patients. Based on specialised postureteroscopic lesion scales such as PULS and Satava, the percentage of complications in Groups I and II was 2.1 and 2.8 and 4.1 and 9.4 (p = 0.03) respectively.Conclusion. The development of acute renal colic in women with patients less intensity than in the male group leads to hospitalisation in the delayed period. In female patients, the number of postureteroscopic complications has higher rates due to the size and density of the stone and its location.
Changes of serum osteoprotegerin level in recurrent urolithiasis
Authors: Savilov A. V. , Jain M. , Tivtikyan A. S. , Kotsepuga M. E. , Anokhin D. M. , Samokhodskaya L. M. , Okhobotov D. A. , Shershnev S. P. , Kamalov A. A. 
Published: October 2023

Introduction.In our earlier research on the role of genetic factors in the development of recurrent urolithiasis, a significant relationship was found between the presence of single-nucleotide polymorphism rs3134057 in the osteoprotegerin (OPG) gene and the development of this disease. The above-mentioned single-nucleotide polymorphism is intronic, therefore, it is unable to involve the structure and functions of the OPG but to affect its expression. Thus, the study of serum OPG level may have diagnostic significance in recurrent urolithiasis.Objective.To study the relationship of serum OPG level with the presence of recurrent urolithiasis, as well as the effect of single nucleotide polymorphism rs3134057 on the OPG level.Materials & methods.One hundred and fifteen volunteers were included in the study from January 2021 to January 2022. Of the 115 participants, 45 (main group #1) were diagnosed with recurrent urolithiasis and localisation of the main stone in one of the ureters, 28 participants (main group #2) had previously suffered a single episode of acute renal colic followed by surgical treatment or stone self-discharge and were stone-free at the time of the study. Forty-two control group respondents were free of urolithiasis, including family history of urolithiasis. The serum OPG levels was determined by enzyme immunoassay using the Human OPG ELISA kit ab100617 ("Abcam plc", Cambridge, UK) according to the manufacturer's advice.Results.The analysis revealed that the serum OPG levels were significantly higher in the main group #1 than in the control group (median: 9.02 vs. 3.635, p = 0.012). When analyzing the relationship between the concentration of OPG in serum and the AA + AG genotype versus GG according to rs3134057 of the OPG gene, no statistically significant difference was found (p > 0.05). The same result was obtained when comparing groups with AA vs. AG vs. GG genotypes (p > 0.05).Conclusion.The present study showed that an increased serum OPG level in patients with recurrent urolithiasis may indicate the presence of a relapse of the disease. Further study in large samples will finally confirm the significance of OPG as a marker of relapse, including in genetically determined forms.