bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metaphorical use of “headache” and “migraine” in media: A longitudinal study of 1.3 million articles in major publications
Authors: Zhang Pengfei , Ventrapragada Advika , Shapiro Robert E. , Do Thien Phu 
Published: January 2024

AbstractBackgroundStigmatization and trivialization of headache confront individuals with headache disorders, but the degree to which media may contribute is incompletely understood.ObjectiveThe objective of this study was to quantify the frequency of disparaging metaphorical use of the words “headache” and “migraine” in articles and summaries of major publications.MethodsThis longitudinal study analyzed a dataset of 1.3 million articles and summaries written by authors and editors of 38 major publications. Data cover written publications from 1998 up to 2017. The use of the words “headache” or “migraine” in articles and summaries by major publications was rated by two authors (P.Z. and A.V.) as either “metaphorical” or “medical” based on their contextual application. Pearson's chi‐squared test was applied to assess differences in the frequency of metaphorical use of “headache” in comparison to “migraine.” Secondary outcomes were the source of publication and time of publication.ResultsA total of 6195 and 740 articles included the words “headache” or “migraine,” respectively; 7100 sentences contained the word “headache” and 1652 sentences contained the word “migraine.” Among a random sample of 1000 sentences with the word “headache,” there was a metaphorical use in 492 (49.2% [95% CI, 46.1–52.3]) sentences. Among a random sample of 1000 sentences with the word “migraine,” there was a metaphorical use in 45 (4.5% [95% CI, 3.2–5.8]) sentences. The five most prevalent sources were CNN, Fox News, The New York Times, The Guardian, and The Washington Post. There was an overall increase in the number of articles containing the words “headache” or “migraine” from database inception until analysis (1998 up to 2017). The database included no articles containing either “headache” or “migraine” in 1998; in 2016, this number was 1480 articles.ConclusionsIn this longitudinal study, major publications applied a metaphorical use of “headache” about half of the time. The metaphorical use of “headache” is 11‐fold greater than the metaphorical use of “migraine” in the same media sample. These depictions may contribute to the trivialization of headache and the stigmatization of individuals with headache disorders. Studies with individuals affected by headache disorders are needed to clarify potential influences.
The effect of phototherapy on Demodex density: a case–control study
Authors: Aksoy Hasan , Aslan Kayıran Melek , Dede Yeşim , Altıntaş Kakşi Sümeyye , Erdemir Vefa A. 
Published: January 2024

AbstractBackgroundHuman Demodex mites,Demodex folliculorumandDemodex brevis, are microorganisms that reside in the pilosebaceous units, usually without causing symptoms. Phototherapy has been linked to demodicosis in previous studies. We aimed to determine whether there was an increase in the frequency of demodicosis and Demodex density after 20 phototherapy sessions.MethodsA case–control study was conducted with 32 participants who received narrowband ultraviolet B or ultraviolet A‐1 therapy for various dermatological indications. Standardized skin surface biopsies were performed before and after phototherapy to assess Demodex density. The presence of Demodex‐related skin conditions was assessed before phototherapy. A statistical analysis was performed to compare the Demodex densities and prevalence of demodicosis between the baseline and 20th session of phototherapy.ResultsNo significant change was observed in Demodex density after 20 sessions of phototherapy. The average Demodex density before treatment was 2.75 ± 4.48 (/cm2), and after treatment, it was 2.85 ± 4.81 (/cm2), indicating no significant difference (P = 0.879). The percentage of patients with demodicosis in at least one region of the face was 28.1% (9/32) before treatment, and after treatment, it was 31.3% (10/32), with no significant difference (P = 1.00).ConclusionsOur findings contradict previous studies that suggested an increased Demodex density and demodicosis prevalence after phototherapy. The data from previous studies are open to debate due to their selected samples, designs, and interpretations regarding the phototherapy–immunosuppression–Demodex relationship. Larger‐scale longitudinal studies conducted on a homogeneous sample are warranted to better understand the relationship between phototherapy and demodicosis.
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy
Authors: Ghanim Hana Y. , Porteus Matthew H. 
Published: January 2024

SummaryInborn errors of immunity (IEI) present a unique paradigm in the realm of gene therapy, emphasizing the need for precision in therapeutic design. As gene therapy transitions from broad‐spectrum gene addition to careful modification of specific genes, the enduring safety and effectiveness of these therapies in clinical settings have become crucial. This review discusses the significance of IEIs as foundational models for pioneering and refining precision medicine. We explore the capabilities of gene addition and gene correction platforms in modifying the DNA sequence of primary cells tailored for IEIs. The review uses four specific IEIs to highlight key issues in gene therapy strategies: X‐linked agammaglobulinemia (XLA), X‐linked chronic granulomatous disease (X‐CGD), X‐linked hyper IgM syndrome (XHIGM), and immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX). We detail the regulatory intricacies and therapeutic innovations for each disorder, incorporating insights from relevant clinical trials. For most IEIs, regulated expression is a vital aspect of the underlying biology, and we discuss the importance of endogenous regulation in developing gene therapy strategies.
Ambulatory arterial stiffness index, mortality, and adverse cardiovascular outcomes; Systematic review and meta‐analysis
Authors: Boos Christopher J. , Hein Aung , Khattab Ahmed 
Published: January 2024

AbstractThe ambulatory arterial stiffness index (AASI) is a novel measure of both blood pressure (BP) variability and arterial stiffness. This systematic review and meta‐analysis was designed to evaluate the strength of the association between AASI and mortality and major adverse cardiovascular events (MACE). PubMed, Scopus, CINAHL, Google Scholar. and the Cochrane library were searched for relevant studies to July 31, 2023. Two investigators independently extracted data. The Newcastle‐Ottawa Scale (NOS) was used to assess the quality of all included articles. The relationship between baseline AASI and outcomes were examined using relative risk (RR) ratios with 95% confidence intervals (CI) with RevMan web. Thirteen studies were included and representing 28 855 adult patients who were followed up from 2.2 to 15.2 years. A 1‐standard deviation (1‐SD) increase in AASI was associated with a significant increase in all‐cause death (RR 1.12; 95% CI: 0.95‐1.32), stroke (RR 1.25; 95% CI: 1.09‐1.44), and MACE (RR 1.07; 95% CI: 1.01‐1.13; [I2 = 32%]). Higher dichotomized AASI (above vs. below researcher defined cut‐offs) was associated with a significant increase in all‐cause mortality (RR 1.19; 95% CI: 1.06‐1.32), cardiovascular death (RR 1.29; 95% CI: 1.14‐1.46), stroke (RR 1.57; 95% CI: 1.33‐1.85), and MACE (RR1.29; 95% CI: 1.16‐1.44). There was a significant risk of bias in more than 50% of studies with no evidence of significant publication bias. Higher AASI is associated with an increased risk of all‐cause and cardiovascular death, stroke, and MACE. Further high‐quality studies are warranted to determine reproducible AASI cut‐offs to enhance its clinical risk precision.
Forecasting the future prevalence of inflammatory bowel disease in Korea through 2048: an epidemiologic study employing autoregressive integrated moving average models
Authors: Kim Ji Eun , Oh Shin Ju , Lee Chang Kyun ,   The Big Data Research Group of the Korean Society of Gastroenterology
Published: January 2024

AbstractBackground and AimThe global inflammatory bowel disease (IBD) escalation has precipitated an increased disease burden and economic impact, particularly in Asia. This study primarily aimed to predict the future prevalence of IBD in Korea and elucidate its evolution pattern.MethodsUsing a validated diagnostic algorithm, we analyzed data from the Korean National Health Insurance Service between 2004 and 2017 to identify patients with IBD. We predicted the number and prevalence of patients with IBD from 2018 to 2048 with the autoregressive integrated moving average method. A generalized linear model (GLM) was also employed to identify factors contributing to the observed trend in IBD prevalence.ResultsOur prediction model validation demonstrated an acceptable error range for IBD prevalence, with a 2.45% error rate and a mean absolute difference of 2.61. We foresee a sustained average annual increase of 4.51 IBD cases per 100 000, culminating in a prevalence of 239.73 per 100 000 by 2048. The forecasted average annual percent change was 6.17% for males and 2.75% for females over the next 30 years. The GLM analysis revealed that age, gender and time significantly impact the prevalence of IBD, with notable disparities observed between genders in specific age groups for both Crohn's disease and ulcerative colitis (all interaction P < 0.05).ConclusionsOur study forecasts a notable increase in Korean IBD prevalence by 2048, particularly among males and the 20–39 age group, highlighting the need to focus on these high‐risk groups to mitigate the future disease burden.
Assessment of prevalence of sunscreen use and related practices among people living in Saudi Arabia: A cross‐sectional survey‐based study
Authors: Hafez Salwa Y. , Alraddadi Eman A. , Ramadan Majed , Alsalamah Faris , Alghumuy Raghad , Aljuhani Faisal F. 
Published: January 2024

AbstractBackgroundThe use of sunscreen significantly reduces the risk of skin cancer and helps maintain skin health; however, improper use can decrease its effectiveness. This study aimed to investigate the prevalence and factors associated with sunscreen use in Saudi Arabia as well as identifying areas of weakness in sunscreen practices.MethodsA cross‐sectional survey‐based study was conducted with a diverse population sample in Saudi Arabia. Participants were asked about their sunscreen usage habits, motivations, and knowledge of proper application techniques. Demographic information, including age, gender, and skin type, were also collected.ResultsA total of 2321 individuals participated in the study. More than two‐thirds of the participants reported using sunscreen either always, regularly, or often, primarily to maintain a light skin color and prevent skin cancer. Factors associated with sunscreen use included younger age (18–40 years old), female gender, history of sunburn, and fair skin. Despite the majority reporting healthy sun exposure habits, several shortcomings were identified in sunscreen practices, including incorrect application and suboptimal reapplication frequency.ConclusionWhile sunscreen use is common among the study population, there is a need for improved education on proper application techniques. National awareness campaigns, especially those utilizing popular social media and digital platforms in Saudi Arabia, should focus on disseminating accurate sunscreen use guidelines to maximize sun protection and skin health.
Escaping iatrogenic harm: A journey into mental health service avoidance
Authors: Aves Wren 
Published: January 2024

Accessible SummaryWhat is known on the subject?

Little is known about how mental health services can cause harm in ways other than medication, talking therapies, diagnosis and detention under the Mental Health Act.

The outcomes of people who avoid seeking help from mental health services due to previous experiences of harm are not well known.

What this article adds to existing knowledge?

I provide a first‐person perspective of experiences of harm within mental health services, how this impacted my care, the long‐term effects of the harm on my well‐being and my ongoing experiences of avoiding mental health services.

What are the implications for mental health nursing?

Healthcare professionals should be aware of the multitude of ways service provision can harm patients, and how, unknown to professionals, patients may create an internal understanding of how to best navigate harmful service environments.

Healthcare professionals should have a deeper understanding of the reasons why people may choose not to engage with mental health services, and what impact this may have on them.

AbstractThe recent announcement of the first ever statutory public inquiry into a UK mental health service indicates a growing recognition of iatrogenic harm in mental healthcare. Despite the potential for harm across all services and practices, restrictive practices, psychotherapy, diagnosis and psychiatric medications are often the only areas of mental healthcare given significant attention. While the topic is widely discussed in survivor communities, accounts of harm caused by the everyday workings of services, including team cultures, administrative processes and staff–patient interactions, are missing from academic literature. In this article, I describe my 10‐year journey through mental health services, and how everyday practices, cultures and staff behaviour deeply impacted my ability to receive appropriate care, replicated previously traumatic environments, and damaged my mental health. Taking steps to protect myself from further harm, I self‐discharged and am currently living as a ‘service‐avoider’. The ongoing implications of this decision and the long‐term impacts of harm are discussed.
When the wounds heal but the soul bleeds—A lived experience narrative
Authors: Anonymous  
Published: January 2024

Accessible SummaryWhat is known on the subject?

This paper acknowledges the profound and lasting impact of childhood abuse on substance use and homelessness.

What this paper adds to existing knowledge?

It underscores the inherent value and humanity of every individual, regardless of their struggles.

That a comprehensive approach to mental health care, encompassing medication, therapy and a secure environment, is imperative.

What are the implications for mental health nursing?

Early intervention and recognising individuals who suffer in silence are paramount. Mental health nurses must have the courage to ask uncomfortable questions and truly hear the unspoken words.

Mental health nurses should never underestimate the power of simply being present with someone during their darkest moments. This simple act can wield significant influence.
Cold urticaria as a complication of cryotherapy in the treatment of viral warts
Authors: Reyes‐Soto Mayra A. , Perales‐González Alejandra , Rivera‐Alonso Iván Alejandro , León Ana Laura Yee‐De , Ocampo‐Candiani Jorge , Muñoz‐Garza Fania Zamantta 
Published: January 2024

AbstractCryotherapy with liquid nitrogen has been established as the first‐line treatment for pediatric patients with viral warts. Cold‐induced urticaria (CU) is a rare skin reaction triggered by cold stimuli. We present the case of a pediatric patient with viral warts who developed CU after receiving cryotherapy.
What theI Chingcan teach us about peaceful equanimity in a rapidly changing world
Authors: Paracka Daniel J. , Pynn Tom 
Published: January 2024

AbstractThis work explores how theI Ching(易經), orBook of Change, as an ancient wisdom text can aid in the development of peaceful equanimity, an important skill given modernity's rapidly accelerating pace of change where processes of globalization have exacerbated a sense of loss of control and climate change demands a more holistic and ecological understanding of well‐being. TheI Chingis a layered text that both predates and informs Confucianism, Daoism, and Chan Buddhism. Its relational focus contributes to the philosophic syncretism of these three teachings that constitute traditional Chinese worldviews. Its consistent advice focuses on understanding how to deal with change by exercising patience, respect, equanimity, and emotional intelligence. Given China's enormous role today, this work promotes a deeper appreciation and understanding for traditional Chinese values that can strengthen international relations wherein ecological and social justice form the foundation for well‐being.
Acute Beetroot Juice Supplementation Has No Effect on Upper- and Lower-Body Maximal Isokinetic Strength and Muscular Endurance in International-Level Male Gymnasts
Authors: Esen Ozcan , Fox Joseph , Karayigit Raci , Walshe Ian 
Published: January 2024

Nitrate () has properties that can improve muscle function, leading to improvements in metabolic cost of exercise as well as enhance force production. Gymnastics is a whole-body sport, involving events that demand a high level of strength and fatigue resistance. However, the effect of supplementation on both upper- and lower-body function in gymnasts is unknown. This study examined the effect of acute beetroot juice (BRJ) supplementation on isokinetic strength and endurance of the upper- and lower-body in highly trained international-level male gymnasts. In a double-blind, randomized crossover design, 10 international-level male gymnasts completed two acute supplementation periods, consuming either 2 × 70 ml -rich (∼12.8 mmol/L of ) or -depleted (PLA) BRJ. Maximal strength of the upper-leg and upper-arm at 60°/s, 120°/s, 180°/s, and 300°/s, and muscular endurance (50 repeated isokinetic contractions at 180°/s) were assessed. Plasma (BRJ: 663 ± 164 μM, PLA: 89 ± 48 μM) and nitrite () concentrations (BRJ: 410 ± 137 nmol/L, PLA: 125 ± 36 nmol/L) were elevated following BRJ compared to PLA (both p < .001). Maximal strength of knee and elbow extensors and flexors did not differ between supplements (p > .05 for all velocities). Similarly, fatigue index of knee and elbow extension and flexion was not different between supplements (all p > .05). Acute BRJ supplementation, containing ∼12.8 mmol/L of , increased plasma and concentrations, but did not enhance isokinetic strength or fatigue resistance of either upper or lower extremities in international-level male gymnasts.
Community ecological succession of endophytic fungi associates with medicinal compound accumulation in
Sophora alopecuroides
Authors: Ju Mingxiu , Zhang Qingchen , Wang Ruotong , Yan Siyuan , Zhang Qiangqiang , Li Peng , Hao Fengxia , Gu Peiwen 
Published: January 2024

ABSTRACT

Endophytic fungi of medicinal plants are symbiotic with the host and play an important role in determining metabolites. To understand the relationship between the accumulation of
Sophora alopecuroides
’ medicinal bioactive compounds and the ecological succession of endophytic fungi, here we collected samples from
S. alopecuroides
at four developmental stages (adult, flowering, podding, and mature) and different organs (roots, stems, leaves, and seeds) at the mature stage. We then used high-performance liquid chromatography-mass spectrometry and high-throughput sequencing on the internal transcribed spacer region to identify the medicinal compounds and endophytic fungal communities in each sample. The endophytic fungal community characteristics and accumulation of medicinally bioactive compounds of
S. alopecuroides
varied with the host’s developmental stages and organs, with the highest total alkaloids content of 111.9 mg/g at the mature stage. Membership analysis and network connection analysis showed a total of 15 core endophytic fungi in different developmental stages and 16 core endophytic fungi in different organs at the mature stage. The unclassified Ascomycota,
Aspergillus
, and
Alternaria
were significantly and positively correlated with the medicinal compounds of
S. alopecuroides
at the mature stage (
r
> 0.6 or
r
< −0.6;
P
< 0.05). In this study, we identified key endophytic fungal resources that affect the content of medicinally bioactive compounds in
S. alopecuroides
. This discovery could lay the foundation for enhancing the yield of medicinally bioactive compounds in
S. alopecuroides
and the development and application of functional endophytic fungi.

IMPORTANCE

Sophora alopecuroides
is a traditional Chinese herbal medicine. The major medicinal chemicals are considered to be quinolizidine alkaloids. Quinolizidine alkaloids have been widely used for the treatment of tumors, dysentery, and enteritis. Previous studies have found that endophytic fungi in
S. alopecuroides
can promote the accumulation of host quinolizidine alkaloids. However, the relationship between the accumulation of
S. alopecuroides
’ medicinal bioactive compounds and the ecological succession of endophytic fungi remains unclear. In this study, we screened the key endophytic fungal resources affecting the content of medicinally bioactive compounds and laid the foundation for subsequent research on the mechanism by which endophytic fungi promote the accumulation of medicinally bioactive compounds in
S. alopecuroides
.
Selective trace elements significantly enhanced methane production in coal bed methane systems by stimulating microbial activity
Authors: Chin Kuk-Jeong , Ünal Burcu , Sanderson Michael , Aboderin Feranmi , Nüsslein Klaus 
Published: January 2024

ABSTRACT

Trace elements are associated with the microbial degradation of organic matter and methanogenesis, as enzymes in metabolic pathways often employ trace elements as essential cofactors. However, only a few studies investigated the effects of trace elements on the metabolic activity of microbial communities associated with biogenic coalbed methane production. We aimed to determine the effects of strategically selected trace elements on structure and function of active bacterial and methanogenic communities to stimulate methane production in subsurface coalbeds. Microcosms were established with produced water and coal from coalbed methane wells located in the Powder River Basin, Wyoming, USA. In initial pilot experiments with eight different trace elements, individual amendments of Co, Cu, and Mo lead to significantly higher methane production. Transcript levels of
mcrA
, the key marker gene for methanogenesis, positively correlated with increased methane production. Phylogenetic analysis of the
mcrA
cDNA library demonstrated compositional shifts of the active methanogenic community and increase of their diversity, particularly of hydrogenotrophic methanogens. High-throughput sequencing of cDNA obtained from 16S rRNA demonstrated active and abundant bacterial groups in response to trace element amendments. Active
Acetobacterium
members increased in response to Co, Cu, and Mo additions. The findings of this study yield new insights into the importance of essential trace elements on the metabolic activity of microbial communities involved in subsurface coalbed methane and provide a better understanding of how microbial community composition is shaped by trace elements.

IMPORTANCE

Microbial life in the deep subsurface of coal beds is limited by nutrient replenishment. While coal bed microbial communities are surrounded by carbon sources, we hypothesized that other nutrients such as trace elements needed as cofactors for enzymes are missing. Amendment of selected trace elements resulted in compositional shifts of the active methanogenic and bacterial communities and correlated with higher transcript levels of
mcrA
. The findings of this study yield new insights to not only identify possible limitations of microbes by replenishment of trace elements within their specific hydrological placement but also into the importance of essential trace elements for the metabolic activity of microbial communities involved in subsurface coalbed methane production and provides a better understanding of how microbial community composition is shaped by trace elements. Furthermore, this finding might help to revive already spent coal bed methane well systems with the ultimate goal to stimulate methane production.