bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric Analysis of the Intersection Between Digital Libraries and Technology in Public Library Services: A Scopus Review (2021-2023)
Authors: Islam Md. Nurul , Haider Mohammad Sohail 
Published: January 2024

Abstract
This paper meticulously reviews research spanning 2021–2023 in digital public library technology. Analyzing 1,626 documents from 753 sources, it uncovers key trends. Despite a -19.59% annual growth rate, collaboration is robust, with 2.71 co-authors per document and 15.31% international collaborations. Fluctuating scientific production and citation metrics raise questions about research impact. Keyword analysis reveals multidimensionality, while identifying influential sources, authors, and globally cited documents. The global landscape analysis underscores broad participation, emphasizing connectivity and evolving research trends. This comprehensive analysis provides a nuanced understanding, guiding future exploration for deeper insights.
Disulfidptosis-related Long Non-Coding RNA signature predicts the prognosis, tumor microenvironment, immunotherapy, and antitumor drug options in colon adenocarcinoma
Authors: Wang Kang , Yu Jing , Xu Qihuan , Peng Yuanhong , Li Haibin , Lu Yan , Ouyang Manzhao 
Published: January 2024

Abstract

This study aims to investigate the role and prognostic significance of long non-coding RNAs (lncRNAs) associated with disulfidptosis in colon adenocarcinoma (COAD). The TCGA database's clinical data and transcriptome profiles were employed. Analysis of previous studies identified 10 disulfidptosis-related genes (DRGs). We used these genes to construct a signature that could independently and accurately predict the prognosis of patients with COAD. The Kaplan-Meier (K-M) curve analysis showed that the lower-risk group had a better prognosis. With the help of multivariate Cox regression analysis, the risk score produced from the patient's signature might independently predict the outcomes. Utilizing a nomogram, the receiver operating characteristic (ROC) curve, and principal component analysis (PCA), the signature's predictive ability was also confirmed. It's interesting to note that immunotherapy, especially PD-1 immune checkpoint suppression, was more likely to benefit low-risk patients. The IC50 levels for certain anticancer agents were lower in the high-risk group. Finally, qRT-PCR analyses in colon cancer cell lines revealed elevated levels of lncRNAs CASC9, ZEB1-AS1, ATP2A1-AS1, SNHG7, AL683813.1, and AP003555.1, and reduced levels of FAM160A1-DT and AC112220.2, compared to normal cell lines. This signature offers insights into prognosis, tumor microenvironment, and options for immunotherapy and antitumor drugs in patients with COAD.
Spatiotemporal Analysis Land Use Land cover changes in South Kashmir Region of North-western Himalayas Using Landsat data
Authors: Mushtaq Shaista , Saleem Shahid , Ahmed Rayees , Rather Javeed A , Rather G. M. 
Published: January 2024

Abstract
This paper presents a comprehensive analysis of land use changes in South Kashmir from 2000 to 2022, revealing significant transformations in various land cover classes. Leveraging remote sensing and geographic information systems (GIS), the study examines the spatial patterns and temporal dynamics of land use and land cover, offering valuable insights into the region's landscape dynamics. Using supervised classification techniques, satellite imagery was analyzed to identify 10 major land use classes. The findings demonstrate notable increases in horticulture and built-up areas, accompanied by declines in agricultural land, glaciers and snow, exposed rock, and water bodies. The expansion of horticultural lands, covering approximately 7% of the study area, has been attributed to the conversion of agricultural lands. This shift, coupled with the encroachment of settlements to accommodate the growing human population, has resulted in a substantial loss of approximately 757 km2 of farmland agriculture, representing a total percentage change of about 13% during the study period. The implications of these changes extend beyond the local region, highlighting the urgent need for comprehensive and sustainable solutions to address human-induced challenges at a global scale. Furthermore, the study underscores the cost-effectiveness and efficacy of geospatial technologies in conducting spatiotemporal analyses and formulating evidence-based policies for the sustainable management of natural resources. The insights gained from this study offer a solid foundation for informed decision-making and the development of targeted land management strategies in South Kashmir and other similar regions facing similar challenges.
Morphological and molecular identification of Euclinostomum heterostomum in the spotted snakehead (Channa punctata) in Narayanganj, Bangladesh
Authors: Bari Sayed Mashequl , Amina Aktia , Nadia Zubyda Mushtari , Shawon Raf Ana Rabbi , Rahman Md. Matiur , Habib Kazi Ahsan 
Published: January 2024

Abstract

Parasites of the Clinostomidae family are widely distributed worldwide. Freshwater fish of Bangladesh frequently serve as hosts for various Clinostomidae species. The metacercariae stage of Euclinostomum heterostomum, a prevalent digenetic trematode, exhibits a distinct affinity for infecting Channidae species and becomes encysted within the liver, kidneys, and muscles of these species. This study focused on identifying E. heterostomum in Channa punctata using a combination of morphological and molecular approaches. The morphological characteristics of the species were examined using both light and scanning electron microscope. Encysted flukes, inflammatory infiltrates of leukocytes, along with degeneration and loosening of hepatic tissue were observed in the histopathological examination of the infected liver tissue. Molecular analysis of the partial nuclear ribosomal internal transcribed spacer (ITS rDNA) sequence confirmed the presence of Euclinostomum heterostomum. A comparison of the collected metacercariae sequence (Accession no. OR591452) with the NCBI GeneBank databases found similarity to other species within the same genus in India and Thailand. The phylogenetic reconstruction provided compelling evidence of genetic similarity among different strains of the genus Euclinostomum, indicating their shared genetic heritage.
Mix Design Procedure for M30 Grade of Fly Ash Based Geopolymer Self Compacting Concrete
Authors: S.Naresh  
Published: January 2024

Abstract
The total world knows about the importance of concrete because it is a major construction material and we know that what are the ingredients in the concrete, the cement is bonding material in the future the high use of cement will create problems because natural resources like limestone get depleted and limestone occupies 60 to 65% of cement and other hand fly ash is creating different types problems for environmental to reducing this all problems some of the researchers are creating geopolymer concrete as solution for all this problems and for this geopolymer concrete mix design procedure are available and other hand we know that importance of self compacted concrete and its usage. The IS 10262-2019, European guidelines by EFNARC are providing guidelines for mix design of self compacted concrete but till now no one is provided guidelines for M30 Grade of Fly Ash Based geopolymer Self Compacting Concrete so here in this paper we will briefly study the guidelines for mix design of Fly Ash Based geopolymer Concrete and also mix design guidelines for self compacted concrete and merge these two guidelines and will provide guidelines for M30 Grade of Fly Ash Based geopolymer Self Compacting Concrete.
Improving technology for manufacturing casting case of truck clutch release cylinder
Authors: Demin Dmitriy 
Published: January 2024

The object of research: Manufacturing technology of body castings for trucks using the example of a clutch release cylinder body made of gray cast iron with flake graphite EN-GJL-200.
Investigated problem: Finding ways to reduce the weight and size characteristics of cast parts.
The main scientific results: A mathematical model has been developed that has made it possible to determine the optimal compositions of alloying Cr/Ni – Cu/Ti complexes that ensure an increase in the grade of cast iron by increasing the tensile strength at elevated carbon contents. This makes it possible in the future to reduce the thickness of the walls of the castings, achieving a reduction in their weight and size characteristics
The area of practical use of the results of the study: Automotive industry in terms of technology for manufacturing cast parts for trucks
Innovative technological product: Improved technology for manufacturing the clutch release cylinder body due to optimization of melt technology and out-of-furnace processing allows for targeted selection of melt processing modes, ensuring an increase in the strength characteristics of cast iron for cast body parts, thereby moving from the EN-GJL-200 cast iron grade to the EN grade -GJL-250 and EN-GJL-300.
The scope of the innovative technological product: Foundries of engineering enterprises, in particular those producing trucks, in which iron castings are produced
The impact of innovation and fintech on the banking business
Authors: Khudolii Yuliia , Hlushko Alina 
Published: January 2024

The object of research. The study analyzes the impact of fintech innovations on the effectiveness of the functioning of the banking business and outlines the prospects for their further implementation in Ukraine, taking into account the EU experience.
Investigated problem. In the conditions of the spread of digitalization processes as a key factor of competitive advantages, the question of researching the introduction of fintech innovations into the banking sector of Ukraine, determining their impact on the effectiveness of the functioning of the banking business, and delineating further prospects for the digitalization of banking institutions' activities becomes relevant.
The main scientific results. The results of the study proved the existence of potential opportunities for expanding the innovative activity of the banking system of Ukraine. In recent years, there has been an intensification of the processes of digitalization of banking services. On the basis of a comparative analysis of the neobanks of Ukraine, their main advantages are outlined and prospective areas of activity expansion are substantiated. At the same time, problematic aspects in the implementation of digital technologies in the banking sector of Ukraine are identified, in particular, imperfect legislation in the field of digital technologies in neobanking and licensing of their activities, low level of financial literacy of the population, expensive initial investments. This requires further research into the possibilities of implementing the positive experience of the EU countries.
The area of practical use of research results. The results of the study can be used by banking institutions of Ukraine when justifying strategies for introducing fintech into their activities.
Innovative technological product. The results of the study made it possible to outline strategic directions for the introduction of digital technologies in the banking sector of Ukraine.
Scope of the innovative technological product. The results of the research concern the implementation of banking innovations.
Transcriptome Sequencing of Gingival Tissues from Impacted Third
Molars Patients Reveals the Alterations of Gene Expression
Authors: Zhou Haolin , Fu Nanqing , Tian Yuan , Zhang Nini , Fan Qin , Zeng Fengjiao , Wang Yueyue , Bai Guohui , Chen Bin 
Published: January 2024

Objective:
The removal of impacted third molars by surgery may occur with a series of
complications, whereas limited information about the postoperative pathogenesis is available.
The objective of this study is to identify changes in gene expression after flap surgical removal of
impacted third molars and provide potential information to reduce postoperative complications.

Methods:
The gingival tissues of twenty patients with flap surgical removal of impacted third
molars and twenty healthy volunteers were collected for gene expression testing. The collected
gingival tissues were used RNA sequencing technology and quantitative real-time PCR validation
was performed. DEG was mapped to protein databases such as GO and KEGG for functional
annotation and, based on annotation information, for mining of differential expression genes in
patients with mpacted third molars.

Results:
A total of 555 genes were differentially expressed. Among the top up-regulated genes,
HLA-DRB4, CCL20, and CXCL8 were strongly associated with immune response and signal
transduction. Among the top down-regulated genes, SPRR2B, CLDN17, LCE3D and LCE3E were
related to keratinocyte differentiation, IFITM5, and BGLAP were related to bone mineralization,
UGT2B17 is associated with susceptibility to osteoporosis. KEGG results showed that the DEGs
were related to multiple disease-related pathways.

Conclusion:
This first transcriptome analysis of gingival tissues from patients with surgical removal
of impacted third molars provides new insights into postoperative genetic changes. The
results may establish a basis for future research on minimizing the incidence of complications
after flap-treated third molars.
Acupuncture Combined with Bushen-Jianpi Decoction Ameliorates the
Ovarian Function of Diminished Ovarian Reserve Rats by Regulating
Phosphoinositide 3-Kinase/AKT Signaling
Authors: Lao Jianting , Hu Panwei , Li Jia , Li Jiahui , Zhang Xiaole , Yang Hong , Qi Cong 
Published: January 2024

Objective:
This study aimed to explore the therapeutic efficiency as well as mechanism
of acupuncture combined with Bushen-Jianpi decoction (BJD) to treat rats with diminished ovarian
reserve (DOR).

Methods:
A DOR rat model was constructed using zona pellucida 3 peptide, and acupuncture,
BJD, and their combination were administered as therapeutic interventions. We measured changes
in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones
and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT,
and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper
17 (Th17), Tc17, regulatory T (Treg), CD4+, and CD8+ cells.

Results:
Acupuncture combined with BJD induced a decrease in the levels of follicle-stimulating
and luteinizing hormones, and the effect was greater than that elicited by BJD or acupuncture
alone (P < 0.05). Additionally, this combination treatment effectively abrogated the increase in
the levels of interleukin-2 (IL-2), IL-17, anti-zona pellucida antibody, and cleaved caspase-3 (P < 0.05), while promoting the regulation of IL-6 and p-AKT (P < 0.01). Furthermore, treatment with
acupuncture combined with BJD restored the proportions of CD4+ cells and the CD4+ / CD8+ T
cell ratio (P < 0.01), decreased the proportion of CD8+ T and Th17 cells (P < 0.01), and increased
the proportions of Tc17 and Treg cells (P < 0.01).

Conclusion:
Combining acupuncture with BJD can enhance ovarian function in DOR rats. The
regulation of sex hormone levels and immune function in rats may be attributed to the adjustment
of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway,
which leads to an improvement in the immune function of DOR rats.
Histone Deacetylase 2 Stabilizes SPARC-related Modular Calcium Binding 2 to Promote Metastasis and Stemness in Gallbladder Cancer
Authors: Feng Ji , Zheng Xueyong 
Published: January 2024

Background:
We aimed to investigate the relationship between histone
deacetylase 2 (HDAC2) and SPARC-related modular calcium binding 2 (SMOC2) and
the role of SMOC2 in gallbladder cancer (GBC).

Methods:
The expression of HDAC2 and SMOC2 in GBC and normal cells was
detected by quantitative real-time reverse transcription polymerase chain reaction
(qRT-PCR), which was also used to detect the mRNA stability of SMOC2. The
combination between HDAC2 and SMOC2 was detected by Chromatin
immunoprecipitation (ChIP) assay. After silencing and/or overexpressing HDAC2 and
SMOC2, cell viability, migration, invasion, and stemness were respectively tested by
the Cell Counting Kit-8 (CCK-8), cell scratch, transwell, and sphere-formation assay.

Results:
In GBC cells, HDAC2 and SMOC2 were highly expressed. HDAC2 combined
with SMOC2 promoted mRNA stability of SMOC2. HDAC2 or SMOC2 overexpression
promoted GBC cell metastasis and stemness. SMOC2 overexpression rescued the
negative effects of silencing HDAC2 in GBC.

Conclusion::
HDAC2 stabilizes SMOC2 to promote metastasis and stemness in
gallbladder cancer.
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Chronic Salpingitis by Modulating Macrophage-Associated Inflammatory Factors
Authors: Liao Wenjuan , Li Xiaomao , Tang Xinrang 
Published: January 2024

Introduction:
Mesenchymal stem cells (MSCs) have been widely studied because of
their established anti-inflammatory properties. During chronic salpingitis (CS), infiltrated
macrophages have vital roles in inflammation and tissue remodeling.

Methods:
We employed the type of MSCs, human umbilical cord (huc) MSCs in an experimental
CS model and therapeutic efficacy was assessed. hucMSCs exerted this therapeutic effect by regulating
macrophage function. To verify the regulatory effects of hucMSCs on the macrophage,
macrophage line RAW264.7 markers were analyzed under LPS stimulation with or without co-culturing
with hucMSCs for 12h and 24h. In addition, flow cytometry analysis was applied to reveal
the interaction of co-culture. For animal studies, CS was induced by the MoPn strain Chlamydia
trachomatis (CT), hucMSCs were intravaginally injected in the CS, and we analyzed the infiltrated
macrophage by immunofluorescence.

Results:
We found the markers IL-10 was markedly increased and IL-1β, caspase-1 was notably
downregulated after co-culturing with hucMSCs by RT-PCR. hucMSCs promote macrophage line
RAW264.7 apoptosis. We also found that hucMSCs treatment can alleviate CS by decreasing the
mRNA expression of IL-1β, caspase-1 and MCP-1 in the tubal tissue by RT-PCR and decreasing
the protein expression of IL-1β, caspase-1 and TGF-β by western blotting.

Conclusion:
These results suggest that macrophage function may be related to the immune-modulating
characteristics of hucMSCs that contribute to CS.
An Open Label Single Arm Clinical Study on Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya in Vishwachi (Cervical Radiculopathy)
Authors: Chaithra M  , Lakshmiprasad L Jadhav  , Bhagia Gayatri Gangaram  
Published: January 2024

Background: Vishwachi is one among the 80 Vatavyadhi. Lakshana of Vishwachi are Bahu Cheshtapaharana, Bahu Karma Kshaya, Stambha, Ruja, Toda, Spandana, Tandra, Gourava and Arochaka. Cervical radiculopathy is a condition similar to Vishwachi, which results from compression of cervical nerve roots. This leads to neck pain radiating along the distribution of the affected nerve root, numbness, altered reflexes and weakness in the muscles of arm. Objectives: To evaluate the combined effectiveness of Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya in Vishwachi (Cervical Radiculopathy). Materials and methods: 30 subjects fulfilling the inclusion criteria were administered with Dashamooladi Yamaka Pratimarsha Nasya in the dose of 2 Bindu twice daily after food and Ashtavargam Kashaya, 15ml thrice daily after food, for 14 days. Ruja, Toda, Spandana, Sthambha, Tandra, Gourava, Arochaka, Bahukarmakshya, Bahucheshtapaharana and Spurling test were assessed on 1 st day, 7th day and 15th day. Data were analyzed using appropriate statistical tests. Results and conclusion: Statistically significant (P < 0.05) improvement was observed in symptoms such as Bahu Karmakshaya, Bahu Cheshtapaharana, Ruja, Toda, Spandana and range of cervical movement. Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya were found to be effective in the management of Vishwachi.
Atualizações de Revisão de Preços comparadas com custos reais de mercado(s) dos materiais: Estudo de Caso
Authors: De Oliveira R.A.F. , Abreu M.I. , Lopes J. 
Published: January 2024

O controlo de custos de empreitadas exige metodologias de gestão cada vez mais ajustadas às especificidades das respetivas obras. Os consideráveis aumentos de custos de materiais, causados pela atual conjuntura de mercado global, exigem tomadas de decisão ajustadas à realidade. A revisão de preços aplicável às empreitadas de construção tem em consideração a atualização de preços com base nos índices atualizados de materiais, mão-de-obra e de equipamentos, onde, por vezes, não compensam a efetiva subida desses preços. A recente legislação (Decreto-Lei 36/2022) que alterou o regime jurídico de revisão de preços contempla a possibilidade de os cocontratantes interessados apresentarem correção ou alteração da fórmula de revisão de preços, quando a apresentada esteja desajustada às especificidades da empreitada ou quando a mesma esteja omissa no caderno de encargos. O artigo envolve a simulação de um caso real de uma obra onde foi aplicada revisão de preços, fazendo-se a comparação entre a compensação retribuída ao empreiteiro atendendo ao preço de determinados materiais na data considerada base de cálculo, e a resultante da efetiva subida de preços desses materiais, sob a forma de diferentes cenários de revisão com base na recente legislação. Este estudo demonstra que, mantendo as fórmulas que servem de base ao cálculo da revisão de preços, o empreiteiro pode ter retribuições que podem ser suficientes para compensar as eventuais subidas de preços de mercado. Em oposição, a utilização de determinados ajustamentos da fórmula-tipo de revisão de preços pode revelar retribuições superiores aos custos reais de mercado dos materiais.
Pengaruh Pola Injeksi PGF2α terhadap Waktu Birahi pada Sapi Friesian Holstein dalam Program Inseminasi Buatan
Authors: Widiarso Budi Purwo , Nugroho Alvin Agung , I Unaz Nurma , Utami Kartika Budi 
Published: January 2024

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh pola injeksi PGF2α alpha terhadap waktu munculnya birahi pada sapi betina Friesian Holstein(FH). Penelitian dilaksanakan di Desa Kopeng Kecamatan Getasan Kabupaten Semarang ± 14 hari mulai tanggal 22 Desember 2022 sampai dengan 5 Januari 2023. Penelitian ini terdiri atas 3 perlakuan. Perlakuan 1(P1) Pola Injeksi tunggal PGF2α . Perlakuan 2(P2) menggunakan pola injeksi PGF2α ganda dan Perlakuan 3 Sebagai kontrol (P0) tanpa menggunakan injeksi PGF2α . Penelitian menggunakan total 15 ekor sapi FH betina. 5 ekor FH betina untuk perlakuan 1(P1) dosis tunggal. Perlakuan 2(P2) menggunkan 5 ekor dengan dua perlakuan injeksi ganda PGF2α dan Perlakuan 3(P0) 5 ekor sapi FH betina yang tidak dinjeksi PGF2α .Injeksi tunggal dengan keberadaan corpus luteum dan injeksi ganda dengan selang waktu 11 hari dari injeksi pertama. Pengamatan estrus dilakukan lima hari berturut-turut setelah injeksi PGF2α yang terakhir. Variabel penelitian yang diamati adalah respon, onset dan durasi estrus. Hasil penelitian menunjukkan bahwa injeksi ganda menghasilkan respon estrus lebih baik dibandingkan injeksi tunggal (100% : 80%), onset estrus lebih pendek (48,17 jam : 54, 50 jam), dan durasi estrus lebih pendek (23, 51 jam : 24,01 jam). Hasil penelitian disimpulkan bahwa respon estrus injeksi PGF2α ganda lebih baik dari injeksi PGF2α tunggal.