bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the molecular switching process between spin crossover states of triazole complexes as basis for optical sensing applications
Authors: Günther Axel , Deja Yves , Kilic Maximilian , Tran Kevin , Kotra Pavan , Renz Franz , Kowalsky Wolfgang , Roth Bernhard 
Published: January 2024

Abstract
With the advent of the first laser sources and suitable detectors, optical sensor applications immediately also came into focus. During the last decades, a huge variety of optial sensor concepts were developed, yet the forecast for the future application potential appears even larger. In this context, the development of new sensor probes at different scales down to the atomic or molecular level open new avenues for research and development. We investigated an iron based triazole molecular spin-crossover complex changing its absorption characteristics significantly by varying environmental parameters such as humidity, temperature, magnetic or electric field, respectively, with respect to its suitability for a new class of versatile molecular sensor probes. Hereby, besides the investigation of synthesized pure bulk material we also studied amorphous micro particles which were applied in or onto optical waveguide structures. The obtained results demonstrate the suitability of the material complex for a broad field of future sensor applications.
Effect of amino silane coupling agent on crystallization behavior of polyamide 612/glass fiber composites
Authors: Yeh Yu-Hsiang , Mao Hsu-I , Chen Chin-Wen , Rwei Syang-Peng 
Published: January 2024

Abstract
Amino silane coupling agents (0, 0.5, 1.0, and 2.0wt %) were added to polyamide 612 (PA612)-based composites reinforced with short glass fibers (GFs) to investigate the effect of the additives on the crystallization kinetics, which were tested using injection molding. The isothermal crystallization activation energies and the kinetic parameters of the crystallization processes of the samples were determined using the Arrhenius, Avrami, and Lauritzen–Hoffman models. The kinetic calculations revealed that the addition of a silane coupling agent significantly benefitted the GFs in terms of slowing down the isothermal crystallization rate of PA612. Moreover, treating the surface of GF-reinforced PA612 composites with a silane coupling agent induced optimum performance of the injection-molded PA612 parts. This is because the GFs enhanced the mechanical properties while the coupling agent delayed crystallization and improved the GF-substrate adhesion. Moreover, compared with a coupling agent-free PA612/GF composite, the activation energy of crystallization was reduced by a factor of over 1.5 from ΔEa -92.84 to ΔEa -163.55 J/mole with the addition of a coupling agent. The experimental results demonstrated that the PA612/GF composite with 1.0wt % coupling agent displayed the highest absolute value of crystallization activation energy (|ΔEa|).
Exploring the potential of three-layered self-assembled biomaterial-based dry powder inhaler for enhanced structural integrity and lung deposition of bioactive Lysozyme
Authors: Thakare Pradip , Chellampillai Bothiraja , Kuvar Vijaykumar , Shinde Vaibhav , Mali Ashwin 
Published: January 2024

Abstract

Aquasome (AQ) is one of the most recently developed self-assembled novel nanocarrier systems that is predominantly effective due to its property of maintaining the structural integrity of proteins, peptides, and delicate bioactive molecules. The objective of the present study was to investigate the feasibility of AQ as a carrier for dry powder inhalers (DPI) to achieve enhanced aerosol performance for Lysozyme (LYS). The water-in-water emulsification method was explored to prepare AQ by using gelatin and cellobiose. The lyophilized LYS-loaded AQ-based dry powder inhaler (DPI) (AQ/LYS-DPI) was evaluated and compared with commercial form of DPI (C-DPI) for its physicochemical properties, in vitro lung deposition, circular dichroism (CD), haemolysis assay, and toxicity study. The developed AQ/LYS-DPI had a particle size of 104.3 ± 3.8 µm, drug loading of 88.70 ± 2.4, and zeta potential of -8.4 mV with sustained release up to 18 h. The mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of AQ/LYS-DPI were found to be 2.43 ± 0.27 µm and 61.52 ± 0.38 %, respectively, reflecting enhanced lung deposition. The CD, hemolytic activity, and toxicity study revealed better structural integrity and biocompatibility with no signs of inflammation or toxicity in the formulation. It was observed that the developed AQ/LYS-DPI effectively controls the structural integrity of lysozyme and can be explored as a novel carrier for pulmonary administration of bioactive molecules.
Vertically Integrated Unconfined Groundwater Flow On Sloping Base
Authors: Strack Otto Dirk Leo 
Published: January 2024

Abstract

We consider unconfined flow in aquifers with a small sloping base, a magnitude of no more than a few percent at maximum and aim the analysis to larg-scale regional modeling using analytic elements . We write the equations for the vertically integrated discharge, and find that the resulting two-dimensional discharge vector is rotational, as opposed to the specific discharge vector. We propose an approximate model for describing three-dimensional flow in an aquifer with a sloping base, and apply the approach to cases of flow between two parallel rivers and flow with a well in an aquifer bounded by a long river. We apply Wirtinger calculus and are able to estimate the error due to the approximation.
A novel resource aware distributed cooperative decision-making mechanism for connected autonomous vehicles
Authors: Ghahremaninejad Reza , Bilgen Semih 
Published: January 2024

Abstract

The need for a cooperative decision-making mechanism for a cluster of Autonomous Vehicles (AVs) is addressed to guarantee safety and decrease energy consumption and travel time. Centralized computation resource utilization cannot ensure the scalability of cooperative applications. This illuminates the need to make use of edge computing resources in the intelligent transportation system. This leads to the distributed implementation of decision-making mechanism for connected AVs. We introduce a novel Resource Aware Distributed implementation of Vector Evaluated Genetic Algorithm (RAD-VEGA) in the vehicular ad-hoc network of connected AVs as a collaborative decision-making algorithm. First, the collaborative decision-making problem is formulated for connected AVs as a Multi-Objective Optimization Problem (MOOP), considering energy consumption and collision risk reduction objectives. RAD-VEGA then solves this MOOP. Performance is evaluated by solving the ZDT1 test problem and comparing found Pareto-frontier solutions with the true front. Then, example cooperative AV planning scenarios simulated in CAVPsim and results of solving the MOOP by RAD-VEGA are discussed to show the effectiveness of the proposed solver.
A Novel Intersection - Cytomegalovirus Gastritis Following Cemiplimab and Talimogene Laherparepvec in a Patient with Advanced Cutaneous Squamous Cell Carcinoma: a Case Report
Authors: Egoryan Goar , Zimmet Alex , Yu Mingwei , Pozdol Joseph , Subramanian Aruna , Reddy Sunil , Nelson Joanna 
Published: January 2024

Abstract
Background
Immunotherapy, particularly immune checkpoint inhibitors, has revolutionized cancer treatment. While effective, these therapies sometimes result in immune-related adverse events and have been associated with infectious complications.
Case presentation:
A 63-year-old South Asian man with a history of cutaneous squamous cell carcinoma, previously treated with cemiplimab and talimogene laherparepvec, was admitted to the hospital with dyspepsia of a six-month duration, anorexia, and a 20 kg weight loss requiring initiation of total parenteral nutrition. Esophagogastroduodenoscopy demonstrated extensive ulceration in the gastric antrum, and biopsy showed cytomegalovirus inclusions with positive immunohistochemistry. Additional immunologic studies failed to identify any underlying immunodeficiency state that might have predisposed the patient to cytomegalovirus infection. After seven weeks of intravenous ganciclovir, the patient reported significant improvement of his symptoms, and his total parenteral nutrition was discontinued.
Conclusions
This case highlights a rare instance of cytomegalovirus reactivation in a patient without prior immune-related adverse events or immunosuppressive therapy, challenging the current understanding of immune checkpoint inhibitors and their association with infections as well as contributes to the evolving landscape of oncology and infectious diseases in immunocompromised hosts, where the interplay between cancer therapy, immune modulation, and infection risk remains a critical area of study.
Comparison of the safety and effectiveness of the four-hook needle and hook wire for the preoperative positioning of localization ground glass nodules
Authors: Wang Yongming , Jing Lijun , Liang Changsheng , Liu Junzhong , Wang Shubo , Wang Gongchao 
Published: January 2024

Abstract

Background
With the implementation of lung cancer screening programs, an increasing number of pulmonary nodules have been detected.Video-assisted thoracoscopic surgery (VATS) could provide adequate tissue specimens for pathological analysis, and has few postoperative complications.However, locating the nodules intraoperatively by palpation can be difficult for thoracic surgeons. The preoperative pulmonary nodule localization technique is a very effective method.We compared the safety and effectiveness of two methods for the preoperative localization of pulmonary ground glass nodules.
Methods
From October 2020 to April 2021, 133 patients who underwent CT-guided single pulmonary nodule localization were retrospectively reviewed. All patients underwent video-assisted thoracoscopic surgery (VATS) after successful localization. Statistical analysis was used to evaluate the localization accuracy, safety, information related to surgery and postoperative pathology information. The aim of this study was to evaluate the clinical effects of the two localization needles.
Results
The mean maximal transverse nodule diameters in the four-hook needle and hook wire groups were 8.97 ± 3.85 mm and 9.00 ± 3.19 mm, respectively (P = 0.967). The localization times in the four-hook needle and hook wire groups were 20.58 ± 2.65 min and 21.43 ± 3.06 min, respectively (P = 0.09). The dislodgement rate was significantly higher in the hook wire group than in the four-hook needle group (7.46% vs. 0, P = 0.024). The mean patient pain scores based on the visual analog scale in the four-hook needle and hook wire groups were 2.87 ± 0.67 and 6.10 ± 2.39, respectively (P = 0.000). All ground glass nodules (GGNs) were successfully resected by VATS.
Conclusions
Preoperative pulmonary nodule localization with both a four-hook needle and hook wire is safe, convenient and effective.
Multimodal MRI lesion habitat-based radiomics analysis for preoperative prediction of spatial pattern in locally recurrent high-grade gliomas
Authors: Wang Han-wei , Zeng Lin-lan , Li Xiao-guang , Zhao Mi-mi , Li Xuan , Feng Ling , Xiang Ping , Chen Li-zhao , Tian Jing , Ran Qi-sheng , Yi Liang , Wang Shu-nan 
Published: January 2024

Abstract
Purpose
This study aims to preoperatively predict spatial patterns in locally recurrent high-grade gliomas (HGGs) based on lesion habitat radiomics analysis of multimodal MRI and to evaluate the predictive performance of this approach.
Methods
Our study included 121 patients with locally recurrent HGGs after maximum safe surgical resections and radiotherapy combined with temozolomide (training set, n = 84; validation set, n = 37). Local recurrence was divided into intra-resection cavity recurrence (ICR) and extra-resection cavity recurrence (ECR), according to the distance between the recurrent tumor and the surgical area or resection cavity. Radiomic features were extracted from the lesion habitat (T1WI enhancing lesion and T2WI/FLAIR hyperintense perilesional region) on contrast-enhanced T1WI and FLAIR, respectively. The LASSO was used to select radiomic features and calculate radiomics score. Logistic regression analysis was used to construct a predictive radiomics model, which was evaluated using calibration curves and the area under the receiver operating characteristic curve (AUC).
Results
Seven features with nonzero coefficients related to spatial recurrence patterns were selected. The radiomics score of patients with ECR was higher than that of patients with ICR in the training set [0.424 (0.278–0.573) vs. -0.030 (-0.226-0.248), p < 0.001] and in the validation set [0.369 (0.258–0.487) vs. 0.277 (0.103–0.322), p = 0.033]. The radiomics model demonstrated good calibration and performed well in predicting ECR, with AUC values of 0.844 in the training set and 0.706 in the validation set.
Conclusion
Radiomics analysis of lesion habitat can preoperatively predict spatial patterns in locally recurrent HGGs, providing a basis for determining personalized treatment strategies for HGGs.
Distribution on the Pattern, Incidence and Determinants of Sexually Transmitted Infections Among Patients Attending Adari Hospital, Hawassa City,Sidama Region, Ethiopia
Authors: Birmeka Melese , Bekele Damtew 
Published: January 2024

Abstract
Background: Sexually transmitted infections cause series medical and psychological health problems in Ethiopia and vary in different localities. Thus, study was aimed to investigate pattern, status and the association of sexually transmitted infections and local risk factors on the patients attending Adari hospital.
Methods: Institutional based cross-sectional study was carried out from September 2021 to June 2022.Systematic simple random sampling was used to select a total of 385 patients. In addition, a five years retrospective data were collected. Data were collected through blood test, urethral and vaginal discharge swabs, structured questionnaire, interview and observation. Variables with p-value less than 5% considered as significant.
Results: The overall prevalence of sexually transmitted infections was 74.4%. The odds of STIs in patients who were urban, single, presence of two and above sexual partners, illiterate, sexual intercourse without using condom, and sex after drinking alcohol and chewing khat were more likely to be infected with STIs as compared with their counter parts.
Conclusions: STIs were highly prevalent and one of health challenges of Hawassa city.
Partly Submerged Quarry in Andriake, the Port of Myra
Authors: Öniz Hakan , Çevik Nevzat , Çakır Çağlar 
Published: January 2024

Abstract
Ancient Lycia is a historical region with high archaeological potential that has been the scene of many civilizations for thousands of years. Many settlements, such as ancient Patara, Myra, and Phaselis, were established on these shores, and hundreds of shipwrecks such as the Kumluca, Uluburun, and Gelidonya Bronze Age shipwrecks have been found on this coastline. Aperlai, Theimussa, Simena, Dolikheste, and the Hellenistic-Roman ruins of Beymelek Lagoon constitute the archaeological settlements of Lycia that were submerged due to earthquakes. Earthquakes between the 1st and 5th centuries caused many collapses and slides on the Lycian coast. Underwater research conducted in 2022 and 2023 shows the collapses also affected a quarry on the coast. This sunken quarry is near Andriake, the port of the ancient city of Myra. Saint Nicholas I settled in Myra during the reign of Constantine (306-337) and became a bishop, causing Myra to be known throughout the Mediterranean. This article aims to understand the capacity of this Quarry near Andriake Port and the characteristics of the submerged part.
The effect of messaging about reductions in exposure to harmful chemicals on perceived risk of JUUL e-cigarettes
Authors: Shiffman Saul , Kim Sooyong , McCaffrey Stacey 
Published: January 2024

Abstract
Adults who smoke (AWS) who switch completely to e-cigarettes reduce their exposures to many harmful chemicals, suggesting that switching could reduce risk. AWS who believe e-cigarettes are less harmful than cigarettes are more likely to use e-cigarettes to switch away from smoking. Yet most AWS believe e-cigarettes are at least as harmful as cigarettes. This study assessed the effect on risk perceptions of communicating that switching can reduce exposure to harmful chemicals. In a randomized experiment, AWS (n=3485), dual users of cigarettes and e-cigarettes (DU; n=1756), and nonusers of tobacco (n=7316) viewed an ad for JUUL with or without a reduced-exposure message, and completed assessments of perceived risk (PR). Message exposure decreased PR of JUUL among AWS, while increasing PR of smoking, thus increasing the perceived risk differential between the two. Among DU, the message increased PR of smoking, but did not change PR of JUUL. Among nonusers, who rated the PR of all assessed tobacco products higher than did AWS and DU, the message decreased PR of JUUL, and did not affect PR of smoking. Accurate modified exposure communications have potential to shift the perceived risk differential of smoking and e-cigarettes in a way that could benefit public health.
Kurtosis assessment of cardiovascular disease risk caused by complex noise in coal mines
Authors: Du Yuanzhen , Tao Xinrong , Chu Fengjen , Zou Yuanjie , Wang Jia , Ding Yu , Mu Min 
Published: January 2024

Abstract
Objectives
This study aimed to investigate the relationship between noise kurtosis and cardiovascular disease risk while exploring the potential of kurtosis assessment in evaluating cardiovascular disease risk associated with complex noise exposure in coal mines.
Methods
A cross-sectional survey involving 1518 participants from the coal mining industry was conducted. Participants completed questionnaire surveys, physical examinations, and assessments of individual noise exposure levels. Individual cardiovascular disease risk was evaluated using the China-PAR algorithm.
Results
Among the participants, 95.03% were male, with a median age of 34.0 years. According to the cardiovascular risk assessment performed using the China-PAR, 637 individuals were classified as low risk, and 68 individuals were categorized as high risk. Notably, the group exposed to noise levels between 85 and 100 dB(A) exhibited a significantly higher risk compared to those exposed to noise levels < 85 dB(A). Regarding kurtosis (β), individuals with β < 3 were associated with low cardiovascular risk, while those with β > 5 had a high risk, with risk increasing alongside kurtosis. Correlation analysis indicated strong associations between noise kurtosis, cumulative noise exposure and cardiovascular disease risk, after accounting for individual age and service duration. Logistic regression analysis identified kurtosis and cumulative noise exposure as the primary influencing factors for cardiovascular disease risk (OR = 3.497, 1.644).
Conclusions
Given the pervasive presence of complex noise in the coal mining industry, kurtosis can serve as a valuable supplementary parameter for adjusting cumulative noise exposure, facilitating the assessment of cardiovascular disease risk associated with complex noise exposure in coal mines.
Differentiation of arc magmas and crustal growth: a Nd isotope perspective
Authors: Chiaradia Massimo 
Published: January 2024

Abstract
Arc magmas form new continental crust and are responsible for volcanic eruptions as well as for major metallic ore deposits. It is generally accepted that arc magmas are generated above subduction zones by partial melting of the mantle wedge and differentiate within the crust of the overriding plate through fractional crystallization, magma mixing and crustal assimilation. However, it is not clear in which proportions mantle and the above different intracrustal processes contribute to the broad geochemical variability of arc magmas. Here, using Nd isotope systematics and their geochemical modelling, I show that the thicker the crust of the overriding plate, the higher the assimilation rate of crustal rocks by mantle-derived magmas and the older the assimilated rocks. This highlights a systematic increase of crustal contribution to arc magma chemical and isotopic composition with the thickening of the overriding plate crust. The data presented are also consistent with growth and maturation of the continental crust through time by continuously increasing thickness, SiO2 content and Nd isotopically evolved composition.
Activation of somatostatin interneurons in the medial amygdala reverses long-term aggressive behavior associated to early-life stress in male mice
Authors: Castillo-Gómez Esther , Mañas-Ojeda Aroa , Hidalgo-Cortés José , García-Mompó Clara , Zahran Mohamed Aly , Gil-Miravet Isis , Olucha-Bordonau Francisco Eliseo , Guirado Ramón 
Published: January 2024

Abstract

Early postnatal development is a critical period for the configuration of neural networks that support emotional and socio-affective behaviors. In this sense, children raised in stressful environments are at high risk of developing maladaptive behaviors immediately or later in life, including anti-social and aggressive behaviors. However, the neurobiological bases of such phenomena remain poorly understood. Here we showed that, at long-term, maternal separation with early weaning (MSEW) decreased the density of somatostatin (SST) interneurons in the basolateral amygdala (BLA) of females and males, while their activity was only reduced in the medial amygdala (MeA) of males. Interestingly, this hypoactivity resulted in increased aggressivity and low social interest. To test whether the manipulation of MeASST+ interneurons was sufficient to reverse these negative behavioral outcomes, we chemogenetically expressed hM3Dq receptors in MSEW adult males. We found that the activation of MeASST+ interneurons ameliorated social interaction and reduced aggression traits. Altogether, our results highlight a role for MeASST+ neurons in the regulation of aggressivity and social interest and point to the loss of activity of these neurons as a plausible etiological mechanism linking early life stress to these maladaptive behaviors in later life.
The Dunkl-Fokker-Planck Equation in 1+1 Dimensions
Authors: Esteves Roberto Daniel Mota , Guillén Didier Ojeda , Merino Miguel Alejandro Xicoténcatl 
Published: January 2024

Abstract
By replacing the spatial derivative with the Dunkl derivative, we generalize the Fokker-Planck equation in (1+1) dimensions. We obtain the Dunkl-Fokker-Planck eigenvalues equation and solve it for the harmonic oscillator plus a centrifugal-type potential. Furthermore, when the drift function is odd, we reduce our results to those of the recently developed Wigner-Dunkl supersymmetry.
PACS: 02.30.Ik, 02.30.Jr, 03.65.Ge, 05.10.Gg
RETRACTED: Eye-related Quality of Life and Motor Skills in Children with Glaucoma
Authors: Zhou Zhuandi , Zhu yingting , Luo Ruiyu , Chen kezhe , Li xinyan , Guo xiaoxin , Yu Xinping , Fu Min , Zhuo Yehong , Huang Wenmin 
Published: January 2024

Abstract
The authors have requested that this preprint be removed from Research Square.