bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enteral Pentobarbital in the Difficult to Sedate Critically Ill Children
Authors: Aljabari Salim , Keaveney Shannon , Anderson Jordan 
Published: February 2024

OBJECTIVE
Difficult analgosedation is common and challenging in the pediatric intensive care unit (PICU). It is important to study alternative and supplemental sedatives for when the first-line agents become ­insufficient.

METHODS
In this retrospective chart-review study, we report our center’s experience in using intermittent doses of enteral pentobarbital as an adjunct sedative in 13 difficult to sedate critically ill and mechanically ventilated children. We compare the average sedation score and cumulative doses of other ­sedatives (opioids, benzodiazepines and alpha-2 agonists) in the 24 hours before and 24 hours after enteral ­pentobarbital initiation.

RESULTS
The addition of enteral pentobarbital was associated with lower State Behavioral State (SBS) scores in 8 out of the 13 patients and on average smaller doses of opioids (decreased by 11%), ­benzodiazepines (BZD) (decreased by 5%) and alpha-agonists (decreased by 20%). No adverse effects were noted attributable to pentobarbital administration.

CONCLUSION
Enteral pentobarbital seems to be safe and effective agent in the difficult to sedate critically ill child.
The Bioavailability of CHF6563, an Ethanol-Free, Sublingual Neonatal Buprenorphine Formulation: A Bridging Study Conducted in Adults
Authors: Kraft Walter K. , Barneschi Irene , Bocchi Maria , Santoro Debora , Cella Massimo 
Published: February 2024

OBJECTIVE
Sublingual buprenorphine has demonstrated efficacy for treatment of the neonatal opioid withdrawal syndrome (NOWS), but the current formulation used in clinical practice contains 30% ethanol. Ethanol as a pharmacologically active excipient ideally should be removed from neonatal formulations. The objective of this study was to determine the relative bioavailability of a novel ethanol-free ­formulation (CHF6563) compared with the commonly used ethanolic solution in a phase I, open-label, 2-period, ­single-dose, crossover study in healthy adults.

METHODS
Eighteen adult opioid-naïve volunteers were administered one of the formulations in a randomized crossover treatment. After a 10-day washout period, subjects received the other formulation. Serial blood samples were drawn for pharmacokinetic analysis over 48 hours.

RESULTS
The geometric mean ratio (90% CIs) of the ethanol-free buprenorphine solution AUC0–last was 0.80 (0.65–0.99) and Cmax was 0.81 (0.66–0.99) compared with reference ethanolic formulation. The ­ethanol-free formulation had a greater degree of intersubject variability than the ethanol-containing ­reference formulation (coefficient of variation of 59% vs 31.5%, respectively, for AUC0–last).

CONCLUSIONS
In an adult population, a novel ethanol-free formulation of buprenorphine containing widely used excipients demonstrated a slight decrease in bioavailability when compared with an ethanolic solution. These results will inform those seeking to develop ethanol-free pediatric drug formulations.
Evaluation of KIDs List Compliance at a Children’s Hospital Within a Large Academic Medical Center
Authors: Cooper Alexandra , Lyons Shannon , Thames Lisa , Scott Timothea , Gayle Ansley , Lehman Alexandra , Higgins Tara 
Published: February 2024

OBJECTIVES
In 2020, a list of Key Potentially Inappropriate Drugs in Pediatrics, known as the “KIDs List,” was published. The objective of this analysis was to evaluate institutional compliance with the ­recommendations in this publication and identify areas for improvement.

METHODS
Medications in the KIDs List were compared to the institutional formulary at a large academic medical center caring for pediatric and adult patients. Medications listed in the formulary were then ­evaluated for order comments and restrictions related to their use in pediatric patients. Oral liquid products and a group of commonly used intravenous (IV) medications were reviewed for potentially inappropriate excipients through available manufacturer information. The pediatric clinical specialists were then solicited to review and make recommendations for medications that had not been addressed.

RESULTS
Of the 67 medications or classes listed in the KIDs List, 47 (70.1%) of the medications are listed in our formulary and available for use. Of these 47 medications, 4 (8.5%) included warnings related to their use in pediatric patients. Of the 270 oral liquid medications reviewed, 206 (76.3%) contained at least 1 ­potentially inappropriate excipient. Of the 20 commonly used IV medications, 3 (15%) contained at least 1 potentially inappropriate excipient.

CONCLUSIONS
This review found that many medications listed in the KIDs List are included in our ­institution’s formulary and that few have warnings for pediatric patients built into the institutional electronic health record. Further review of medications in the formulary will be conducted to determine the next steps to implementing KIDs List recommendations.
PENERAPAN CRM SOSIAL UNTUK MENINGKATKAN HUBUNGAN PELANGGAN
Authors: Novita Adinda Putri 
Published: February 2024

Social Customer Relationship Management (Social CRM) diterapkan untuk meningkatkan hubungan dengan pelanggan dalam menyediakan informasi perusahaan, mempromosikan produk, mengetahui ketertarikan dan mendengarkan kritik serta saran pelanggan. Sistem yang dibangun menggunakan metode pengembangan sistem FAST dan memanfaatkan media sosial Facebook PT. Greentech Equipment Indonesia. Hasil penelitian ini merupakan sistem Social CRM yang mendukung pengelolaan hubungan pelanggan dengan memanfaatkan media sosial Facebook.
DAMPAK PROMOSI ONLINE SERTA MUTU LAYANAN PENGIRIMAN KEPADA LOYALITAS KONSUMEN TERHADAP APLIKASI GRAB
Authors: Nainggolan Hotnida , Dewantara Rizki 
Published: February 2024

Penelitian ini bertujuan untuk menguji pengaruh promosi dan kualitas pelayanan terhadap loyalitas pelanggan pada aplikasi Grab di Kota Pelembang. Grab, sebagai penyedia layanan transportasi dan pengiriman barang berbasis aplikasi, menghadapi persaingan yang ketat dalam industri ini. Oleh karena itu, memahami faktor-faktor yang mempengaruhi loyalitas pelanggan menjadi penting untuk meningkatkan daya saing perusahaan. Jenis penelitian yang digunakan casual comparative research. Populasi dalam penelitian ini adalah pengguna aplikasi Grab yang berdomisili di Kota Palembang Sumatera Selatan. Teknik penentuan sampel menggunakan purposive sampling dengan jumlah sampel sebanyak 100 responden dengan menggunakan rumus lemeshow. Pengumpulan data menggunakn kuesioner dengan media goggle form. Teknik analisa yang digunakan adalah metode metode anlisis jalur (path analysis). Pengolahan dan penganalisaan data dalam penelitian ini dengan menggunakan bantuan program SPSS versi 25 yang digunakan untuk menghitung nilai statistik berupa uji instrumen, uji asumsi klasik dan uji hipotesis. Penelitian ini juga memberikan kontribusi teoritis terhadap literatur manajemen pemasaran dengan menggambarkan dinamika faktor-faktor yang memengaruhi loyalitas pelanggan dalam konteks layanan berbasis aplikasi. Implikasi praktis dari penelitian ini dapat membantu manajemen Grab dan perusahaan sejenis dalam mengembangkan strategi yang lebih efektif untuk memenangkan hati dan menjaga loyalitas pelanggan dalam lingkungan bisnis yang cepat berubah. Hasil penelitian ini diharapkan dapat memberikan pemahaman yang lebih mendalam tentang bagaimana promise dan kualitas pelayanan berkontribusi terhadap loyalitas pelanggan di konteks aplikasi Grab. Temuan ini dapat menjadi dasar strategi perusahaan dalam meningkatkan layanan dan memperkuat hubungan dengan pelanggan, sehingga dapat mempertahankan dan meningkatkan jumlah pengguna aplikasi Grab di Kota Palembang. Hasil pengujian ini menunjukan bahwa promosi berpengaruh positif terhadap signifikan terhadap loyalitas pelanggan, dan kualitas pelayanan berpengaruh positif terhadap loyalitas pelanggan.
ANALISIS PERSEPSI KONSUMEN TERHADAP JASA BELANJA ONLINE SHOPEE
Authors: Kusuma Triana Hasty , Safitri Anni 
Published: February 2024

Persepsi konsumen dalam melakukan pembelian secara online pada suatu produk atau jasa dengan merk tertentu pasti tidak terlepas dari adanya suatu faktor. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang dapat mempengaruhi persepsi masyarakat (konsumen) selama berbelanja di shopee dan bagaimana kepuasan pembeli di Teknologi Internet era sekarang ini. Yang menjadi fokus penelitian yaitu faktor harga, kualitas produk dan kualitas pelayanan terhadap jasa belanja online Shopee. Jenis penelitian ini menggunakan penelitian kualitatif dengan metode pengumpulan data melalui wawancara. Metode pengambilan sampel dalam penelitian ini menggunakan metode accidental random sampling, yaitu pengambilan sampel dari anggota populasi acak, populasi yang dapat ditemui dengan mudah yang dengan senang hati memberikannya. Berdasarkan hasil penelitian bahwa persepsi konsumen dalam hal pertama harga, konsumen merasa puas dan tidak merasa terbebani dengan harga yang ada di Shopee, walapun dua informan ada yang mengatakan harga di Shopee lebih mahal daripada di pasaran. Kedua, faktor Kualitas produk, yang dibutuhkan 10% informan tidak puas karena kualitas produk cacat, 30% informan kurang puas karena kualitas barang yang dipesan tidak sesuai dengan yang mereka lihat di Shopee dan 60% informan puas akan kualitas produk yang dibutuhkan. Ketiga, faktor Kualitas Pelayanan, 60% responden puas dalam pelayanan karyawan juga puas dalam pengiriman barang karena barang sampai tepat waktu dan diterima dalam keadaan baik, 30% responden kurang puas karena sikap dan cara penyampaian yang kurang mudah dimengerti serta 10% responden tidak puas terhadap pelayanan karena barang lama sampai dan penjual shopee lambat respon.
Effect of Production, Price, and Rupiah Exchange Rate on the Export Value of Cocoa Beans (HS 1801) in Indonesia
Authors: Sari Sinta Dewi Kumala , Imaningsih Niniek 
Published: February 2024

Among Indonesia's many plantation exports, cocoa beans play a starring role. In general, the trends in the export value of cocoa beans is inseparable from external changes including prices, production, and exchange rates. The purpose of this study is to determine the effect of the independent variables cocoa bean price (X1), rupiah exchange rate (X2), and cocoa bean production (X3) on the dependent variable Indonesian cocoa bean export value (Y). This research uses a quantitative approach in the form of a time series. the data used is secondary data sourced from the Badan Pusat Statistik, Bank Indonesia, and the International Cocoa Organization starting from 2008 to 2022. The data analysis method is multiple linear regression (ordinary Least Square). Based on the results of the analysis obtained information that the price of cocoa beans has a significant impact on the export value of cocoa beans, the rupiah exchange rate has no affect the export value of cocoa beans, and cocoa bean production has a significant impact on the export value of Indonesian cocoa beans.
Warum der Konflikt um das EU-Lieferkettengesetz eines haftungsrechtlichen Mittelwegs bedarf
Authors: Meder Paul 
Published: February 2024

Die Abstimmung im Rat der Europäischen Union um ein EU-Lieferkettengesetz ist auf ungewisse Zeit aufgeschoben. Nach Deutschlands Enthaltung kamen wie erwartet auch andere Staaten ins Zweifeln. Auslöser für die plötzliche – und für viele Mitgliedstaaten überraschende – Kehrtwende der Bundesrepublik ist eine Blockade durch die FDP. Die Minister Buschmann und Lindner fürchteten, „dass Unternehmen für Pflichtverletzungen in der Lieferkette in erheblicher Weise zivilrechtlich haften würden.“ Die sich unter anderem am Thema Haftung entzündende Kontroverse – so die These dieses Textes – ist jedoch auflösbar.
The Effectiveness of a Counseling Program Based on Humanistic Therapy to Reduce Situational Remorse, Guilt and Pessimism among a Sample of Students of Disintegrated Families
Authors: Dalaein Anas 
Published: February 2024

The current study aimed to reveal the effectiveness of a counseling program based on humanistic therapy to reduce situational remorse, guilt and pessimism among a sample of students of disintegrated families. The sample of the study consisted of (26) students. Measurements for situational remorse, guilt and pessimism were developed. The validity and reliability of their psychometric characteristics were verrified, and a counseling program based on the humanistic theory was built. The results of the study showed that there were statistically significant differences in the ranks of the mean scores of feelings of situational remorse, guilt and pessimism in the experimental group in the post-measurement compared with the control group, and that there are no differences between the mean scores of the experimental group in the post and follow-up measurements in the scale of situational remorse, guilt and pessimism. The study came out with some recommendations, including the need to use the current counseling program in helping students to reduce each of the students' feelings of situational remorse, guilt and pessimism.
An innovative air-cooling system for efficiency improvement of retrofitted rooftop photovoltaic module using cross-flow fan
Authors: Mustafa Rozita , Mohd Radzi Mohd Amran Bin , Hizam Hashim Bin , Che Soh Azura 
Published: February 2024

This study presents an innovative air-cooling photovoltaic (PV)system using cross-flow fan with speed regulation to optimize performance of rooftop PVsystem in tropical climates like Malaysia. Air passed through the impeller enters perpendicularly to the motor shaft, deflected by the fan blades and evacuated, allowing the fan to operate at its most efficient operating point. The airflow provided within the rear of the PV modules and the roof surface blow out the trapped hot air. Changes in the module temperature (Tcell) are detected and the fan speed are adjusted accordingly to the PWM. This method was tested for 12 hours continuously from 7:00 am on the existing PV system at German Malaysian Institute (GMI) Bangi. The highest Tcell achieved 72.88 °C and 55.75°C without and with air-cooling system with average power 210.22 W and 246.67 W per peak sun factor (PSF) respectively. There was a 17.34% increase in average power with a 13.18% in average net output power and achieved 6.68% energy efficiency using the proposed cooling system. Tcell increases more swiftly and reaches higher temperatures in the absence of a cooling system, whereas Tcell increases more slowly and at lower temperatures when a cooling system is present. The projected system's power rating was 6.48 W, which is 2.6% per PV module, and it really attained 6.32 W, which is 2.53% per PV module, while total energy consumption by the fan was 51.89 Wh per day, which is only 3.89% per PV module.
Kekuatan Hukum dan Aspek Keamanan Dalam Tanda Tangan Elektronik
Authors: Triana Wati  
Published: February 2024

An Electronic Signature is an electronically generated signature used for authentication and verification of electronic documents. Electronic Signature has the potential to replace wet signatures in a variety of transactions, including contracts, agreements, and other legal documents. Electronic Signature is regulated in Law Number 11 of 2008 concerning Electronic Information and Transactions. Article 11 of the Electronic Signature Law states that Electronic Signature has legal force and legal consequences that are valid and binding as long as it meets certain requirements. The security aspect is also an important consideration in the use of Electronic Signature. Electronic Signature must be guaranteed authenticity and integrity so that it cannot be falsified or altered. This journal discusses the legal strength and security aspects of Electronic Signature. This journal aims to provide a better understanding of Electronic Signature and how Electronic Signature can be used safely and effectively in various transactions
Diplomacia ushtarake kineze në kuadër të marrëdhënieve Shqipëri-Kinë: Një trajtesë nga arkivat shqiptare
Authors: Smaçi Etleva 
Published: February 2024

Ky punim synon të analizojë raportet diplomatike në fushën ushtarake mes Shqipërisë dhe Kinës nga viti 1963 deri në vitin 1975. Periudha kohore e zgjedhur për analizë përkon me momentin e intensifikimit të marrëdhënieve ushtarake e shkon deri në bjerrjen e tyre, pa ndonjë fërkim dhe demonstrim force siç ndodhi me Bashkimin Sovjetik.Teza qendrore e këtij punimi është se marrëdhëniet ushtarake Shqipëri-Kinë ishin marrëdhënie të pastra interesi ekonomik dhe ideologjik, pa pika takimi në parime dhe doktrina ushtarake. Si të tilla, ato kushtëzuan tjetërsimet doktrinore dhe qasjen për rolin e ushtrisë shqiptare në fushën e mbrojtjes. Në mbështetje të kësaj teze, analizohen arsyet politike që përcaktuan një diplomaci ushtarake soft dhe smart nga pala kineze, duke shkurajuar çdo përpjekje shqiptare për një aleancë mirëfilli ushtarake apo iniciativa në fushën e mbrojtjes dhe të sigurisë që binte ndesh me politikën e jashtme të Kinës.Metodologjia e përdorur në këtë punim është një shqyrtim i literaturës historike të autorëve të huaj dhe vendës, që kanë analizuar disa nga aspektet më të rëndësishme politike dhe ekonomike të marrëdhënieve shqiptaro-kineze. Fokusi në çështjet ushtarake dhe shfrytëzimi i burimeve arkivore të Arkivit Qendror të Forcave të Armatosura të Shqipërisë është një risi, në raport me punimet e mëparshme që trajtojnë aleancën shqiptaro-kineze.
Ballafaqimi i këtyre dokumenteve me literaturën e përdorur gjykojmë se do të japë një panoramë më të plotë se në ç’raport qëndronin lidhjet ushtarake të Kinës me Shqipërinë në politikën e jashtme të të dyja vendeve, veçanërisht Kinës. Përfundimet bazohen kryesisht në dokumentacionin shqiptar. Analiza e marrëdhënieve ushtarake përfshin raportet e të dyja vendeve duke cekur raportet e secilit prej tyre me Traktatin e Varshavës (TV), organizatë ushtarake dhe politike e vendeve komuniste, kundërshtare e NATO-s. Për ta përmbyllur, simbioza ushtarako - politike e Kinës dhe e Shqipërisë në përballje me Bashkimin Sovjetik, është një pazëll interesant idesh dhe mesazesh që vlejnë të deshifrohen në kuadër të studimit të historisë së Luftës së Ftohtë brenda vetë Kampit Komunist.
SANITATION PRACTICES, DISPOSAL METHODS AND AWARENESS OF HEALTH HAZARDS OF INDISCRIMINATE DISPOSAL OF ELECTRICAL/ELECTRONIC DEVICES	AMONG STUDENTS
Authors: SOYINKA-BUSARI, Olabisi  , EZEOGUINE, Juliana. A.  , EZEKWERE, P. U.  
Published: February 2024

The study investigated sanitation practices, disposal methods and awareness of health hazards of indiscriminate disposal of electrical/electronic devices among students of Federal College of Education (Technical) Akoka, Lagos. A descriptive survey design was employed in the study. Two hundred (200) students from four (4) schools representing fifty (50) per school were randomly sampled for the study. A structured questionnaire titled "Assessment of digital waste disposal, sanitation practices and health management among students of Federal College of Education (Technical) Akoka, Lagos' was developed and used to assess responses from students. The research instrument was given face validity by lecturers in the Department of Home Economics Education. Some copies of the questionnaire were subjected to pilot testing and data obtained analyzed using Cronbach Alpha. A reliability coefficient (r) of 0.6452 obtained indicated the internal consistence of the instrument. All necessary corrections and comments were made before the main study. The researcher personally administered the questionnaires with 92.5% returns. Data were analysed using frequency, percentages and mean scores. Mean scores 2.50 and above were considered as 'Agree', while those below 2.50 'Disagree' on a scale of 4-points Likert scale. The results indicated that there are existing sanitation practices such as such as sweeping, scrubbing, regular disinfecting toilet and disposing waste into bigger refuse /waste bins among the students of FCE (T) Akoka. The students indiscriminately dispose electrical/electronic devices using wrong methods. The students are not aware of health hazard of their indiscriminate disposal of electrical/electronic devices.
Occurrence and Antifungal Susceptibility of Candida Species Isolated from Pregnant Women in a Tertiary Hospital
Authors: Adogo L. Y. , Julia K. M. , Joshua P. D. 
Published: February 2024

Candida is the leading cause of infection among pregnant women. This study was aimed to determine the occurrence and antifungal susceptibility of Candida species isolated from apparently healthy pregnant women receiving antenatal care at Bingham University Teaching Hospital. High vaginal swab was inoculated onto Sabouraud Dextrose Agar and Gram staining was carried out. Candida isolates were sub- cultured on Himedia CHROM Candida differential agar and identified according to their color, morphology, and appearance. Disc antifungal susceptibility test was carried out using standard protocols. The occurrence rate of vulvovaginal candidiasis (VVC) in this study was 42.5%. In this study, Candia albicans was the most predominant Candida species (51.2%) isolated. Pregnant women within the age range of 20-24 years had the highest infection occurrence of 100% while the lowest occurrence of the infection (25%) was observed among women within the age range of 40-44 years. There was a significant relationship between age and VVC infection (P>0.05). In relation to trimester, pregnant women in the second trimester had a high infection rate of 87.5% while women in the third trimester had the least occurrence rate of 10.9%. There was a significant relationship between vulvovaginal candidiasis infection and trimester (P>0.05). All Candida species were resistant to the antifungal drugs tested except for Candida kefyr which was susceptible to fluconazole and voriconazole. Therefore, early diagnosis and appropriate treatment among pregnant women receiving antenatal care can reduce the infection and prevent complications during childbirth
Social Acceptance and Social, Economic, and Environmental Impact of Renewable Energy - A Case Study from Hanimaadhoo Island, Maldives
Authors: NOBORU ZAMA  , MASACHIKA SUZUKI  , SHAZLY AMINATH 
Published: February 2024

Social acceptance particularly public opposition on renewable energy have been key obstacles for renewable energy deployment in many developed nations particularly in Europe. The level of awareness of the situation in the global south, particularly in Small Island Developing States (SIDS), was rather limited. This research utilizes Cultural Theory as a framework, incorporating data obtained from household questionnaire surveys, focus group discussion and individual interviews conducted on Hanimaadhoo island in the Maldives. The objective is to gain a more comprehensive understanding of how individuals’ worldviews influence their opinions and behaviors regarding renewable energy. This study also aims to comprehend the anticipated social, economic, and environmental impacts of renewable energy. The authors highlight key findings from a local perspective that they deem crucial to consider for the future deployment and diffusion of renewable energy in the Maldives