bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compression terms: Defining terminology of compression therapy - An international compression club consensus document
Authors: Mosti Giovanni , Benigni Jean P. , Bohbot Serge , Devoogdt Nele , Forner-Cordero Isabel , da Matta Eduardo , Rastel Didier , Roes Claas , Thomis Sara 
Published: February 2025

Background The terminology in compression therapy is not always consistent. Confusion arises from layers, components, materials, whether elastic or inelastic, stiff or not stiff, compression class, and other terms. The aim of this paper is to define a standard terminology for compression therapy. Method the International Compression Club (ICC) board members prepared a draft consensus paper, which was circulated among the ICC members and refined by GM according to the comments and suggestions received. Results All the terms used in compression therapy, from the definition to the materials, compression kits or systems, their physical properties, compression pressure, compression characteristics, and components and layers, were considered and agreed upon. Conclusions The given definitions allow for consistent classification of compression materials or devices. The International Compression Club hopes that the proposed terminology will be widely accepted and that papers and congress presentations on compression will use precise terminology.
fMRI Activation in Sensorimotor Regions at 6 Weeks After Anterior Cruciate Ligament Reconstruction
Authors: Culiver Adam M. , Grooms Dustin R. , Caccese Jaclyn B. , Hayes Scott M. , Schmitt Laura C. , Oñate James A. 
Published: February 2025

Background: Brain activity during knee movements is altered throughout the sensorimotor network after anterior cruciate ligament reconstruction (ACLR). Patients at 2 to 5 years after surgery appear to require greater neural activity to perform basic knee movement patterns, but it is unclear if brain activity differences within sensorimotor regions are present early after surgery. It is also unknown whether uninvolved knee movements elicit similar or unique activity compared with involved knee movements. Purpose: To examine brain activity in sensorimotor regions during involved and uninvolved knee movements in patients at 6 weeks after ACLR compared with control participants. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 15 patients who underwent ACLR (mean age, 21.9 ± 4.3 years [range, 17-29 years]; 8 female) and 15 control participants performed 30-second blocks of repeated knee flexion and extension, followed by 30 seconds of rest, during functional magnetic resonance imaging. Regions of interest included the right and left primary motor cortex (M1), right and left primary somatosensory cortex (S1), supplementary motor area (SMA), precuneus, and lingual gyrus. Activity from task-relevant voxels (move > rest) was extracted, and generalized estimating equations evaluated the main effect of group and group-by-limb interaction. Effect sizes were calculated using the Cohen d. Results: Reduced brain activity during knee flexion and extension was observed in the ACLR group in the ipsilateral M1 and S1, contralateral S1, SMA, and precuneus during movements of the involved and uninvolved knees. There were no group-by-limb interaction effects, indicating no significant differences between the involved knee and uninvolved knee in the ACLR group. Medium to large effect sizes were identified for between-group differences in all regions. Conclusion: At 6 weeks after ACLR, patients exhibited bilateral reductions in brain activity during knee movements in multiple sensorimotor regions. These identified regions are associated with motor planning, motor execution, somatosensory function, and sensorimotor integration. These data indicate that ACLR affected sensorimotor brain activity in both limbs during the early postoperative phase of rehabilitation.
Clinical Outcomes of Fully Arthroscopic Versus Arthroscopically Assisted Latissimus Dorsi Transfer for Irreparable Subscapularis Tear
Authors: Kim Bo Taek , Miranda Luis Alfredo , Baek Chang Hee , Kim Jung Gon , Diaz Luis Leoncio Temoche , Baek Gyu Rim , Kany Jean 
Published: February 2025

Background: Untreated chronic subscapularis (SSC) tears pose a challenging problem to treat owing to the resultant tendon retraction, atrophy, fatty infiltration, and changes in humeral head position, which complicate surgical options. Anterior latissimus dorsi (LD) transfer has shown effective results in treating these tears without glenohumeral arthritis. Purpose/Hypothesis: This study introduces and evaluates fully arthroscopic and arthroscopically assisted anterior LD transfer techniques for reconstructing irreparable SSC tears. The authors hypothesize that both methods will yield promising and comparable clinical outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: This retrospective study reviewed patients who underwent anterior LD tendon transfer between February 2014 and April 2022. Indications for surgery included persistent shoulder pain and functional limitations unresponsive to nonoperative treatment, irreparable SSC tears (Lafosse grade ≥4), significant fatty infiltration (Goutallier grade ≥3), and minimal glenohumeral arthritis (Hamada stage <3). Patients were excluded if they had <2 years of follow-up or if data were lost. For comparison, the study divided patients into 2 groups based on the surgical methods: fully arthroscopic LD tendon transfer and arthroscopically assisted LD tendon transfer. Clinical assessments included pain levels (visual analog scale), Constant score, Subjective Shoulder Value score, and range of motion. Radiologic measurement and complications were assessed. Results: The study included 34 patients (mean ± SD age, 62.4 ± 7.5 years; follow-up, 35.4 ± 15.9 months). Significant improvements were observed in all patient-reported outcomes (pre- to posttest visual analog scale, 7.5 ± 1.2 to 1.2 ± 1.6; Constant score, 28.3 ± 6.0 to 68.8 ± 15.8; Subjective Shoulder Value, 23.2 ± 8.7 to 65.3 ± 22.0; all P < .001), range of motion in all directions, and internal rotation strength. Fully arthroscopic (n = 18) and arthroscopically assisted (n = 16) LD tendon transfers produced comparable clinical outcomes. Complications included 3 retears, 3 infections, and 5 cases of arthritis progression. Conclusion: Fully arthroscopic and arthroscopically assisted anterior LD transfers significantly reduce pain, enhance range of motion, and strengthen internal rotation in patients with irreparable SSC tears, with no significant differences in complications. These techniques offer comparable clinical outcomes, providing different options for surgeons.
Relationship Between the Prognostic Nutritional index and Short-Term Prognosis among Patients with Community-Acquired Bacterial Pneumonia: A Retrospective Analysis of the MIMIC-IV
Authors: Wu Qingsong , Liao Lianyi , Deng Qingjun 
Published: February 2025

Objectives The objective of this study was to investigate the association between the prognostic nutritional index (PNI) and the short-term outcomes in patients with community-acquired bacterial pneumonia (CABP). Design This study employed a retrospective design, utilizing data from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Participants 371 individuals from the MIMIC-IV database who were diagnosed with CABP. Primary and secondary outcomes The primary endpoint was 28-day all-cause mortality. The secondary endpoint was the length of stay (LOS) in the intensive care unit (ICU) and in hospital. Results The area under the curve of PNI for predicting 28-day all-cause mortality is 0.702 (95% CI 0.630 to 0.775; p < 0.001). Patients were divided into two groups based on their PNI at admission: the low PNI (<35.75) group and the high PNI group (≥35.75). CABP patients with higher PNI presented a lower 28-day all-cause mortality rate (adjusted HR: 0.53, 95% CI 0.28-0.98, p = 0.044). Moreover, a negative linear correlation was found between the PNI and short-term mortality rates via restricted cubic splines. Eventually, there was no difference in the LOS in the ICU or hospital between the two groups. Conclusion These findings suggest a negative correlation between the PNI at admission and the short-term mortality rate of CABP. PNI is helpful for early identification of high-risk patients.
Towards safer mines: Analyzing occupational health and safety perceptions and injury patterns in Serbian underground mining
Authors: Ivaz Jelena S , Fedajev Aleksandra N , Petrović Dejan V , Stojadinović Saša S , Zlatanović Dragan M , Stojković Pavle Z , Stajić Milan S , Radovanović Mladen B 
Published: February 2025

Background Mining is a high-risk sector, particularly in underground environments, where workers face daily hazards. This research evaluates workplace safety perceptions in Serbian underground coal mines, ranking workers by education, age, and job role, while incorporating injury data to provide a comprehensive assessment of safety across different worker groups. Objective This study is aimed at analyses of the correlation between occupational health and safety (OHS) perceptions and the injury index across different worker groups, to identify improvement opportunities and propose targeted measures for enhancing OHS practices. Methods The PROMETHEE II method categorized workers based on production units, qualifications, and age, focusing on criteria like protective equipment, work conditions, risk awareness, management, work organization, and training. The entropy method provided objective weightings for these criteria, allowing for comparison with injury index rankings to establish priorities for improvement. Results Štavalj and Vrška Čuka ranked highest in OHS perception. Workers with MSc/Dr qualifications displayed heightened awareness of safety, while those aged 56 to 65 exhibited the best understanding of health and safety. Spearman rank correlation coefficients revealed a strong negative correlation (−0.796) for production units, a strong positive correlation (0.70) for qualifications, and a very strong positive correlation (0.90) for age concerning PROMETHEE II rankings and injury index indicators. Conclusions The disparities between worker perception rankings and injury index rankings suggest opportunities for targeted safety improvements and enhanced training protocols.
Increasing trends in utilization of physical and occupational therapy services in early Parkinson's disease
Authors: Longhurst Jason K , Chrusciel Timothy , Ahmad Syed O 
Published: February 2025

Background Best practice guidelines in Parkinson's disease (PD) calls for the immediate initiation of rehabilitation therapies (inclusive of physical (PT) and occupational therapy (OT)) to prevent or ameliorate the loss of function and quality of life associated with disease progression. Objective The purpose of this study was to determine the utilization of PT and OT services within the first 2 years following PD diagnosis and to observe longitudinal trends in PT and OT utilization early following PD diagnosis. Methods This retrospective cohort study accessed 12 years (2011 to 2023) of data from electronic health records at a midwestern US healthy system. Patients with new PD diagnoses and two-years of visit history were included. The primary outcome was utilization of PT or OT services within two-years of PD diagnosis. Data extracted included demographics and PD therapies. Records of 9720 patients were included in the analyses. Results Overall, 36.9% of the cohort ( n = 3586) received either physical or occupational therapy within two years of receipt of PD diagnosis. Increasing age, higher comorbidity index, female gender, use of dopamine replacement therapies, and African American race were all positively associated with receipt of PT or OT services ( ps < 0.007). The longitudinal trend revealed an average year over year increase in PT/OT utilization of 1.4% between 2013 and 2021 ( p < 0.001). Conclusions This study shows a promising increase in utilization of PT and OT services over previous reports and longitudinally, however it continues to convey how far clinical practice continues to lag behind best practice and scientific recommendation.
Tectonometamorphic evolution of a subduction plate interface at the base of the Mirdita Ophiolite (Bajram Curri, northeastern Albania)
Authors: Richter Madeline , Pollok Kilian , Onuzi Kujtim , Ustaszewski Kamil 
Published: February 2025

Abstract
The Western Vardar ophiolite, a thrust sheet of oceanic crust and mantle obducted onto the Adriatic passive margin in the Late Jurassic, crops out along the entire Balkan Peninsula. The Mirdita Ophiolite forms the northern Albanian segment of this unit. In northeast Albania near Bajram Curri, a 200–700 m thick metamorphic sole is preserved at its base. The assembly of obducted mantle rocks and metamorphic sole constitutes a plate interface that formed during the intraoceanic subduction stage preceding obduction; we call this a fossil intraoceanic plate interface in this paper. This setting allows to study the interrelated tectonometamorphic evolution and rock-water interaction between the subducted and exhumed metamorphic sole and concomitant mantle wedge serpentinization in the overlying units. We combined detailed lithological and structural mapping with micro-scale analyses along this plate interface. Three tectonic units were distinguished. Mylonitic harzburgites overlie a tightly folded, tectonised subophiolitic mélange along a SE-dipping contact that defines the fossil intraoceanic plate interface. The tectonised subophiolitic mélange itself was separated into a structurally lower non-metamorphic broken formation and a higher metamorphic sole, separated by an isoclinally folded thrust. Within the metamorphic sole, the temperature and degree of deformation increase towards the structural top. Shear sense indicators in calcschists of the metamorphic sole show top to the west transport of the overriding units. All metamorphic sole lithologies were overprinted at lower greenschist-facies conditions, reflecting their exhumation from intraoceanic subduction. Corresponding microstructures indicate mineral growth at isotropic stresses, suggesting that deformation migrated into structurally lower, frontally accreted non-metamorphic units of the sub-ophiolitic mélange marking the start of obduction onto the passive Adriatic margin. Ongoing westward transport led to folding of the entire sub-ophiolitic succession. Harzburgites are more deformed towards the plate interface, forming a mylonitic fabric. There, harzburgites contain accessory Cr-rich spinel and the foliation is dissected by multiple generations of veins containing serpentine and magnetite. Vein density is highest along the plate interface and decreases up-section, suggesting that serpentinisation was triggered by devolatilisation reactions in the sediments of the metamorphic sole that were subducting below the harzburgites, and the upwards migration of volatiles into the overlying mantle wedge.
sORFdb – a database for sORFs, small proteins, and small protein families in bacteria
Authors: Hahnfeld Julian M. , Schwengers Oliver , Jelonek Lukas , Diedrich Sonja , Cemič Franz , Goesmann Alexander 
Published: February 2025

Abstract
Small proteins with fewer than 100, particularly fewer than 50, amino acids are still largely unexplored. Nonetheless, they represent an essential part of bacteria’s often neglected genetic repertoire. In recent years, the development of ribosome profiling protocols has led to the detection of an increasing number of previously unknown small proteins. Despite this, they are overlooked in many cases by automated genome annotation pipelines, and often, no functional descriptions can be assigned due to a lack of known homologs. To understand and overcome these limitations, the current abundance of small proteins in existing databases was evaluated, and a new dedicated database for small proteins and their potential functions, called ’sORFdb’, was created. To this end, small proteins were extracted from annotated bacterial genomes in the GenBank database. Subsequently, they were quality-filtered, compared, and complemented with proteins from Swiss-Prot, UniProt, and SmProt to ensure reliable identification and characterization of small proteins. Families of similar small proteins were created using bidirectional best BLAST hits followed by Markov clustering. Analysis of small proteins in public databases revealed that their number is still limited due to historical and technical constraints. Additionally, functional descriptions were often missing despite the presence of potential homologs. As expected, a taxonomic bias was evident in over-represented clinically relevant bacteria. This new and comprehensive database is accessible via a feature-rich website providing specialized search features for sORFs and small proteins of high quality. Additionally, small protein families with Hidden Markov Models and information on taxonomic distribution and other physicochemical properties are available. In conclusion, the novel small protein database sORFdb is a specialized, taxonomy-independent database that improves the findability and classification of sORFs, small proteins, and their functions in bacteria, thereby supporting their future detection and consistent annotation. All sORFdb data is freely accessible via https://sorfdb.computational.bio.
Seed endophytes of malting barley from different locations are shaped differently and are associated with malt quality traits
Authors: Ajayi Oyeyemi , Mahalingam Ramamurthy 
Published: February 2025

Abstract
Maximizing microbial functions for improving crop performance requires better understanding of the important drivers of plant-associated microbiomes. However, it remains unclear the forces that shapes microbial structure and assembly, and how plant seed-microbiome interactions impact grain quality. In this work, we characterized the seed endophytic microbial communities of malting barley from different geographical locations and investigated associations between microbial (bacterial and fungal) species diversity and malt quality traits. Host genotype, location, and interactions (genotype x location) significantly impacted the seed endophytic microbial communities. Taxonomic composition analysis identified the most abundant genera for bacterial and fungal communities to be Bacillus (belonging to phylum Firmicutes) and Blumeria (belonging to phylum Ascomycota), respectively. We observed that a greater proportion of bacterial amplicon sequence variants (bacterial ASVs) were shared across genotypes and across locations while the greater proportion of the fungal ASVs were unique to each genotype and location. Association analysis showed a significant negative correlation between bacterial alpha diversity indices (Faith PD and Shannon indices) and malt quality traits for barley protein (BP), free amino nitrogen (FAN), diastatic power (DP) and alpha amylase (AA), while fungal alpha diversity (Shannon and Simpson) showed significant negative relationship with β-D-glucan content. In addition, some bacterial and fungal genera were significantly associated with malt extract (ME) -a key trait for maltsters and brewers. We conclude that barley genotype, location, and their interactions shape the seed endophytic microbiome and is key to microbiome manipulation and management during barley production and/or malting.
Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study
Authors: Rahden Paul , Barrow Ebrima , Bah Haddy , Bittaye Sheikh Omar , Nygren David , Badjan Abdoulie 
Published: February 2025

Abstract

Introduction
Antimicrobial resistance is a significant global health concern, particularly in western Sub-Saharan Africa. This study describes causes of bloodstream infections and antimicrobial resistance at a tertiary hospital in The Gambia.

Methods
This retrospective analysis included all blood cultures performed at the Edward Francis Small Teaching Hospital, Banjul, The Gambia, from September 2022 to August 2023. Blood culture positivity-rates and pathogens were described. Antimicrobial susceptibility testing was performed using disk diffusion following the Clinical & Laboratory Standards Institute guidelines.

Results
A total of 645 patients had blood cultures drawn during the study period with 260 (40%) positive results. Contaminants were identified in 28 cases (4%). The majority were drawn from neonatal or paediatric patients (360/645, 56%) and overall primarily in intensive care units (406/645, 63%). The median age was 3 years (interquartile range 0–31 years) and 46% were female. The most common pathogens were Staphylococcus aureus 106/260 (41%), Klebsiella spp. 41/260 (16%), other bacteria within the Enterobacterales order 33/260 (13%), Pseudomonas spp. 22/260 (8%) and Acinetobacter spp. 19/260 (7%). Methicillin-resistant S. aureus (MRSA) was seen in 34/58 (59%) tested. Extended-spectrum beta-lactamases (ESBL) were seen in 36/40 (90%) of Klebsiella spp. and in 16/28 (57%) of other bacteria within the Enterobacterales order. Acquired antibiotic resistance, beyond wild-type, was reported in 17/20 (85%) of Pseudomonas spp. and 16/19 (84%) of Acinetobacter spp.

Conclusion
Overall, blood culture positivity rates were high, indicating restrictive testing suggesting that sample collection were restricted to mainly critically ill, neonatal or paediatric patients. Nonetheless, our data suggests a high proportion of bloodstream infections due to multi-drug resistant pathogens, including MRSA and ESBL-Enterobacterales. Importantly, generalisability of findings beyond this tertiary hospital setting remains restricted. However, our findings demonstrate a need for improved diagnostic stewardship and ongoing surveillance to provide robust evidence-based data to inform antimicrobial resistance interventions.
Chitosan-covered tamponade for the treatment of postpartum hemorrhage: a registry-based cohort study assessing outcomes and risk factors for treatment failure
Authors: Leichtle Clara , Aigner Annette , Biele Carolin , Hermann Paulina , Dangli Teresa , Waldner Charlotte , Braun Thorsten , Henrich Wolfgang , Dückelmann Anna Maria 
Published: February 2025

Abstract

Background
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide. Intrauterine hemostatic devices are recommended when PPH does not respond to medical treatment. The objective of this study was to assess the factors leading to unsuccessful intrauterine therapy with a chitosan-covered tamponade (CT) for the treatment of PPH and to evaluate clinical outcomes based on real-world data.

Methods
This registry-based cohort study included all women treated with CT for PPH between January 2017 and June 2022 at a university clinic’s perinatal department. The endpoint was defined as the failure of CT, indicated by the requirement of further invasive procedures for ongoing hemorrhage after CT application. Medical records were reviewed and binary logistic regressions used to evaluate delivery mode, placenta previa, and placenta accreta spectrum as potential risk factors for CT treatment failure.

Results
The cohort consisted of 230 women, with successful CT treatment in 91.3%. The success rate for mild PPH was 100.0%, for moderate 95.5%, and for severe 84.2%. Five hysterectomies were performed in total. Placenta previa in cesarean sections was identified as the primary risk factor for CT treatment failure, increasing the odds about 7.5-fold (Odds Ratio: 7.48; 95% CI: 1.87–33.15) compared to cesarean sections without placenta previa. Furthermore, delays in CT insertion may also contribute to treatment failure.

Conclusion
CT serves as an intrauterine treatment for medically intractable PPH. Placenta previa significantly increases the risk of CT treatment failure in cesarean sections. Obstetricians should be particularly vigilant in managing patients with placenta previa and consider early use of CT or a combination of procedures.

Trial registration
This study was approved by the local Ethics Committee on 11/10/2021 (EA4/231/21).