Laparoscopic right hemicolectomy: a SICE (Società Italiana di Chirurgia Endoscopica e Nuove tecnologie) network prospective study on the approach to right colon lymphadenectomy in Italy: is there a standard?—CoDIG 2 (ColonDx Italian Group)
Authors: Anania G. , Chiozza M. , Campagnaro A. , Bagolini F. , Resta G. , Azzolina D. , Silecchia G. , Cirocchi R. , Agrusa A. , Cuccurullo D. , Guerrieri M. ,   SICE CoDIG (ColonDx Italian Group), Adamo V. , Ammendola M. , Angelini P. , Annecchiarico M. , Aprea G. , Autori F. , Baldazzi G. , Balla A. , Baronio G. , Bellio G. , Bertelli G. , Bima C. , Bonomo L. D. , Borreca D. , Botteri E. , Brescia A. , Cafagna L. , Capelli P. , Caracino V. , Caricato M. , Carlini M. , Cassinotti E. , Catarci M. , Chiaro P. , Cillara N. , Clementi M. , Contul R. B. , Curro G. , De Manzini N. , Degiuli M. , Delogu D. , Di Leo A. , Elmore U. , Ercolani G. , Festa F. , Galleano R. , Gambino G. , Gelmini R. , Giordano A. , La Mendola R. , Laface L. , Masoni L. , Maurizi A. , Memeo R. , Mercantini P. , Merola G. , Milone M. , Montuori M. , Morelli L. , Muttillo I. A. , Nascimbeni R. , Nelli T. , Olmi S. , Ortenzi M. , Patriti A. , Pavone G. , Pisano M. , Polastri R. , Rega D. , Rottoli M. , Saladino E , Santarelli M. , Santoro R. , Sartori A. , Scatizzi M. , Sica G. , Siquini W. , Sorrentino M. , Staderini F. , Vincentini L. , Aizza G. , Ammendola M. , Amodio P. , Aquilino F. , Argenio G. , Avanzolini A. , Baldari L. , Banchini F. , Benedetti M. , Bertino V. , Bianco A. , Blasi F. , Bonariol L. , Bono D. , Bottari A. , Buscemi S. , Calini G. , Campagnacci R. , Cantafio S. , Capolupo G. T. , Capuano M. , Carannante F. , Casati M. , Cassini D. , Castiglioni S. , Cecconi C. , Cestino L. , Chetta N. , Chiappetta F. M. , Cinelli L. , Cojutti A. , Colettta D. , Corallino D. , Crepaz L. , Curcio S. , Cuticone G. , D’Agostino F. , De Luca M. , De Palma G. D. , De Rosa C. , De Serra A. , Del Giudice R. , Di Franco G. , Foglio F. , Fontani G. , Fortuna L. , Fortunato M. R. , Frazzini D. , Furbetta N. , Gambino E. , Garosio I. , Germani P. , Ghazouani O. , Giannotti D. , Gibin E. , Grasso A. , Grieco M. , Izzo D. , Laracca G. G. , Lauteri G. , Lepiane P. , Li Causi F. S. , Locci E. , Lorenzo G. , Madaro A. , Madeddu F. , Maggi F. , Maiello F. , Manigrasso M. , Marcellinaro R. , Marinello P. , Mattei M. S. , Mazzarella G. , Merola G. , Moroni F. , Murgese A. , Muttillo E. M. , Oldani A. , Paicilli M. , Palmieri M. , Palomba G. , Paolini G. , Parini D. , Paroli G. M. , Pellicciaro M. , Petrucciani N. , Picardi B. , Piccolo R. , Pinotti E. , Pisanu A. , Reddavid R. , Resendiz A. , Romano G. , Rossi E. G. , Saracco R. , Scaramuzzo R. , Serra F. , Sgotto E. , Solaini L. , Spalluto M. , Taglietti L. , Tartaglia E. , Tartaglia N. , Torre B. , Tutino R. , Varesano M. , Vettoretto N. , Villamaina E. , Viora T. , Yusef M. , Zago M. , Zerbinati A. 
Published: January 2024

Abstract
Background
Colon cancer is a disease with a worldwide spread. Surgery is the best option for the treatment of advanced colon cancer, but some aspects are still debated, such as the extent of lymphadenectomy. In Japanese guidelines, the gold standard was D3 dissection to remove the central lymph nodes (203, 213, and 223), but in 2009, Hoenberger et al. introduced the concept of complete mesocolic excision, in which surgical dissection follows the embryological planes to remove the mesentery entirely to prevent leakage of cancer cells and collect more lymph nodes. Our study describes how lymphadenectomy is currently performed in major Italian centers with an unclear indication on the type of lymphadenectomy that should be performed during right hemicolectomy (RH).

Methods
CoDIG 2 is an observational multicenter national study that involves 76 Italian general surgery wards highly specialized in colorectal surgery. Each center was asked not to modify their usual surgical and clinical practices. The aim of the study was to assess the preference of Italian surgeons on the type of lymphadenectomy to perform during RH and the rise of any new trends or modifications in habits compared to the findings of the CoDIG 1 study conducted 4 years ago.

Results
A total of 788 patients were enrolled. The most commonly used surgical technique was laparoscopic (82.1%) with intracorporeal (73.4%), side-to-side (98.7%), or isoperistaltic (96.0%) anastomosis. The lymph nodes at the origin of the vessels were harvested in an inferior number of cases (203, 213, and 223: 42.4%, 31.1%, and 20.3%, respectively). A comparison between CoDIG 1 and CoDIG 2 showed a stable trend in surgical techniques and complications, with an increase in the robotic approach (7.7% vs. 12.3%).

Conclusions
This analysis shows how lymphadenectomy is performed in Italy to achieve oncological outcomes in RH, although the technique to achieve a higher lymph node count has not yet been standardized.
Trial registration (ClinicalTrials.gov) ID: NCT05943951.