bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstetric cholestasis and its impact on the maternal outcome
Authors: TIWARI EKTA , PARVEEN SHAZIA , NOOR NASREEN 
Published: January 2024

Abstract
AIM
To evaluate the association of GDM and pre-eclampsia in women with obstetric cholestasis
MATERIAL AND METHODS
Pregnant women with >28weeks gestation attending ANC, OPD and labour room of J.N.M.C.H,AMU, Aligarh U.P (India) from 2020-2022 were included in the study after taking informed consent and ethical approval from the Institute. Women were divided into two groups ie group 1 having 200 women with IHCP and group 2 having 200 healthy pregnant women, both the groups were followed up for the development of GDM and pre-eclampsia.
RESULTS
A statistically significant association was observed between IHCP and development of GDM (26.5% & Odds ratio 1.64) and pre-eclampsia (17% & Odds ratio 1.95) (p<0.05), also GDM and pre-eclampsia were found to be significantly associated with the severity of cholestasis (p<0.05).
Thus on calculating odds ratio, we found higher odds of developing GDM and Pre-eclampsia in IHCP group with raised serum bile acid levels, maximum at 60μmol/L level as compared to 10-40 μmol/L (GDM: OR:8.647 & Pre-eclampsia: OR:6.303). Induction and cesarean rate was significantly higher in IHCP group (p<0.05).
CONCLUSION
Our study concludes significant association of IHCP with GDM and Pre- eclampsia as all three shares common pathogenetic pathways and greater risk of development was at higher serum bile acid levels.
Does Business Environment Optimization Improve Carbon Emission Efficiency? Evidence from Provincial Panel Data in China
Authors: Li Peiyu , Liu Xinzhi 
Published: January 2024

Abstract
Previous research has yielded varied conclusions regarding the effect of business environment (BE) optimization to improve carbon emission efficiency (CEE). In this study, CEE and BE are assessed using energy consumption and economic growth data from 30 provinces in China. The research employs fixed effects, quantile, and mediation effect models to analyze the direct impact, nonlinear characteristics, mechanism, and heterogeneity of BE on CEE. The research found that. Firstly, the BE optimization enhances CEE, with a 1% increase leading to a 0.095% improvement in CEE. Secondly, the influence of the BE on CEE exhibits marginal diminishing traits that decline as CEE improves. Thirdly, the analysis of mechanisms reveals that the BE primarily impacts CEE through positive mechanisms such as industrial structure optimization and green technology progress, as well as a negative mechanism known as the energy rebound effect. Lastly, the analysis of heterogeneity indicates that the BE exerts a more substantial influence on CEE in regions characterized by robust government governance, younger officials, and highly educated officials. These findings offer valuable insights for local governments seeking to leverage the BE to enhance energy efficiency and foster sustainable development.
Composite rectification in modeling of rolling force for hot rolled thick plate
Authors: Guo Xiao Xiao , Zhang Shun Hu , Wang Li , Li Wei Gang , Zhang Lei 
Published: January 2024

Abstract
In order to eliminate the predicted bias of the traditional Sims model, a new method, called the composite rectification method, is firstly proposed. Firstly, the deformation resistance model based on industrial big data is built based on the generalized additive principle. This new model is adopted to replace the deformation resistance model in the Sims model. Through this factor replacement, the effect of deformation resistance bias due to the traditional regression method was eliminated, resulting in the once-time corrected Sims model with significantly improved accuracy compared to the original Sims model. On this basis, to solve the mathematical form imperfection caused by the introduction of many assumptions during the derivation of the Sims model, a back propagation (BP) neural network model on the bias of the once-time corrected Sims model is built. Ultimately, the double correction of the Sims model is realized through the additive compensation method, and an integrated model of rolling force is ultimately obtained. By comparing, it is shown that the average error of the traditional Sims model is as high as 34.22%. This error can be minimized to 9.40% with once-time correction and further reduced to 3.06% with the double correction. The results show that the prediction accuracy of the rolling force can be improved gradually by the proposed composite rectification method, and the bias brought by model influence factor and mathematical formcan be eliminated. The composite rectification method presented in this article can provide a new way of modeling complex systems with high precision.
Herpes Simplex Virus Reactivation Incidence and Prophylaxis in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Aleissa Muneerah , Alsuhebany Nada , Alshehri Bashayer , Aldairem Atheer , AlQatani Hajar , Albarqi Khalid , Almotairi Basil , AlAmri Mohammed , Alanazi Walid , Alay Saeed , Alahmari Bader , Alzahrani Mohsen 
Published: January 2024

Abstract
Patients undergoing Hematopoietic Stem Cell Transplantation (HSCT) are at increased risk for reactivation of herpes simplex virus (HSV) infection due to their immunocompromised state. This retrospective cohort study assesses the efficacy of Acyclovir (ACV) prophylaxis against HSV reactivation in allogeneic HSCT (allo-HSCT) recipients in Saudi Arabia. Conducted at a single institution from January 2016 to March 2023, and the study included 371 allo-HSCT patients aged over 14 who received oral ACV post-transplantation. Statistical analyses, including Chi-squared, Fisher’s exact, and independent T-tests, evaluated the data, while Cox and multivariable logistic regression models identified risk factors and the impact on overall survival (OS). Findings show that the two-year incidence of HSV reactivation was 11.3% in patients with malignant hematological conditions and 8.6% in those with non-malignant conditions. A total of 93.5% of patients received 400 mg of ACV orally twice daily. High HCT CI scores (≥ 3), underlying malignant conditions, and graft-versus-host disease emerged as significant reactivation predictors. The study concludes that HSV reactivation, occurring in approximately 10% of the cohort, correlates with a decline in OS. It suggests that patients with higher risk profiles may benefit from intensified HSV prophylaxis, providing a foundation for potential adjustments in clinical protocols at our institution.
A Mendelian randomization study: Association of Cathepsin with Osteoarticular Muscle Diseases
Authors: Yang Wei , Han Xiuzhen , Cui Miao , Guan Mengqi , Yu Qingyuan , Yang Peng , Li Zhenhua 
Published: January 2024

Abstract
Objective: The cathepsin present in lysosomal cells may be closely related to bone, muscle & joint diseases (BMJD)including osteoporosis and osteoarthritis, but its specific mechanism of action still needs further research and exploration. The aim of this study is to use a two-sample Mendelian randomization (MR) comprehensive analysis to explore the causal relationship between cathepsin and the risk of BMJD.
Method: Based on the published genetic data, this study used a two-sample Mendelian randomization (MR) comprehensive analysis method to explore the causality of morbidity risk between 9 cathepsins with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, peripheral arthritis(Crohn's disease, ulcerative colitis, and postdysentery joint disease), psoriatic joint disease, lower back pain, spinal stenosis, osteoporosis, bone necrosis, and connective tissue disease, cartilage diseases, benign tumors, myositis, synovitis and tenosynovitis (radial styloid tenosynovitis), shoulder periarthritis, neuromuscular junction diseases, and muscle atrophy. Meanwhile, in order to further reveal the possibility of reverse causality, we conducted a reverse Mendelian randomization analysis,using Cochran's Q test and MR Egger intercept test to evaluate the heterogeneity, horizontal pleiotropy,and stability of SNPs.
Result: The study found that cathepsin B may be negatively correlated with ulcerative colitis arthritis, cathepsin E may be positively correlated with osteoarthritis, cathepsin E may be negatively correlated with musculoskeletal connective tissue diseases, cathepsin G may be positively correlated with ankylosing spondylitis, and cathepsin L2 may be positively correlated with cartilage diseases, Cathepsin S may be positively correlated with rheumatoid arthritis; through reverse MR analysis, we found that osteoporosis may lead to an increase in cathepsin B. In addition, we did not find any relationship between synovitis, tenosynovitis, shoulder periarthritis, bone necrosis, neuritis, osteoporosis,Crohn's arthritis,dysentery arthritis, psoriatic arthritis, low back pain,and cathepsin.
Conclusion: Based on large-scale population studies of GWAS data, we conducted MR analysis and demonstrated a close relationship between cathepsins and BMJD from a genetic perspective, which may provide a basis for the pathogenesis of BMJD and provide new directions for future treatment strategies.
Abdominal Wall and limb necrotizing fasciitis: an extremely rare post -operative complication
Authors: Sakhri Saida , Krimi Ons , Khessairi Nayssem , Abidi Fethia , Slimane Maher , Bouaziz Hanen , Dhiab Tarek Ben 
Published: January 2024

Abstract
Introduction:
Infectious affections are the most frequent post-operative complications, the rates have been reducing due to the administration of perioperative antibiotics and they are rarely serious. They are usually associated to pelvic collections, fistulas, urinary tract stenosis and, exceptionally, necrotizing fasciitis (FN) and pelvic organ necrosis [1].There is no well-codified therapeutic consensus,. An urgent care of pelvic necrosis requires surgical debridement of necrotic tissues with a broad-spectrum antibiotic.
Case presentation: A 42-year-old female patient, was referred to our department for a stage IIIC2 adenocarcinoma of the uterine cervix. She underwent chemo-radiation followed by a colpo-hysterectomy . Two months after surgery, the patient presented with recto-vaginal fistula associated with a pelvic collection. Abdominal CT scan revealed a recto-vaginal fistula fed by a 5cm pelvic collection originating from the uterine cavity. The patient was treated with antibiotics and then underwent a surgical evacuation of the collection and a bypass colostomy. The post-operative period was marked by the occurrence of an extensive necrosis to pelvic organs, namely the bladder and the anterior wall of the rectum which extended to the anterior and medial left leg’s thigh compartments muscles. She also presented a thrombosis of the left external iliac vein and artery, with necrosis of their vascular walls. Given the septic conditions, a revascularization procedure was not feasible. A bilateral ureterostomy was required, as well as ligature of the left external iliac vessels. The patient underwent post-surgical palliative treatment, and she died one month after surgery of multivisceral failure due to sepsis.
Conclusion: Necrotizing fasciitis is a rare, but extremely serious condition, with a mortality rate of up to 30%. The prognosis can be improved with rapid management and appropriate medical and surgical treatment including large excisions of necrotic tissue, and antibiotic therapy adapted to the suspected germs, essentially anaerobic ones.
Producing supersaturated dissolved oxygen seawater and its applications
Authors: Hirayama Shin , Urata Kazuya , Kusumoto Miyuki , Ikegami Yasuyuki 
Published: January 2024

Abstract
Conditions for photosynthetically generating high concentrations of dissolved oxygen were evaluated using sterile Ulva lactuca. During culture under, we controlled the following conditions such as aeration, NO3-N concentration, and population density. As a result, it reached approximately 3.8 times its saturated concentration 3 hours after cultivation. Here, we show that this high level of dissolved oxygen can be maintained if the seal on the supersaturated dissolved oxygen seawater is properly maintained. Seawater with high levels of dissolved oxygen is essential for growing oysters and vivalve which also prefer 20-25℃ of growth temperature. Therefore, we have developed a new system for simultaneously growing sterile Ulva sp. and culturing oysters.
The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients who underwent gastrointestinal tumor surgery: a randomized double-blind controlled study
Authors: Ma Xiaoyan , Yu Wenli , Jia Lili , Sheng Mingwei , Weng Yiqi , Sun Ying , Yang Lirong 
Published: January 2024

Abstract
Background: We aimed to whether esketamine induction and maintenance of general anesthesia could reduce the incidence of perioperative neurocognitive dysfunction (PND) in elderly patients undergoing gastrointestinal tumor surgery and explore the related mechanisms preliminarily.
Patients and methods: A total of 153 elderly patients were divided into two groups: a control group (group C, n=75) and an esketamine group (group K, n=78). In group K, 0.3 mg/kg esketamine was injected intravenously during anesthesia induction, and 0.3 mg·kg-1·h-1 was injected intravenously to maintain anesthesia. In group C, esketamine was replaced with an equal volume of normal saline. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality 1 day before surgery and at 1, 3, 7, and 30 days after surgery. A battery of neurological tests was used to assess cognitive function 1 day before surgery and 7 and 30 days after surgery. Serum IL-6, TNF-α, NSE and Aβ1~42 concentrations were tested by enzyme-linked immunosorbent assay before surgery, at the end of surgery and 1 day after surgery.
Results: The incidence of PND in group K at 7 days after surgery was lower than that in group C (P<0.05). Compared with that in group C, the PSQI score in group K was lower at 1 and 3 days after surgery (P<0.05). Compared with those in group C, the TNF-ɑ concentration in group K were lower both after surgery and 1 day after surgery (P<0.05), and the IL-6, NSE and Aβ1-42 concentration were lower at 1 day after surgery (P<0.05).
Conclusion: The use of esketamine for anesthesia induction and maintenance in elderly patients undergoing gastrointestinal tumor surgery inhibited inflammation, alleviated neuronal injury and degeneration, improved postoperative sleep quality and cognitive function, and reduced the incidence of PND.
Disruption and sustainment of cognitive behavioral therapy for chronic pain in the Veterans Health Administration following the onset of the COVID-19 pandemic
Authors: McGuire Alan , Flanagan Mindy , Coffing Jessica , Traylor Morgan , Myers Laura , Henry Nancy , Carter Jessica , Kukla Marina , Matthias Marianne 
Published: January 2024

Abstract
The sustainability of evidence-based practices (EBPs) is a pressing issue for implementation science and healthcare systems. The COVID-19 pandemic and related policies severely strained healthcare systems, thus representing a key test of the sustainability of EBPs. The current study examined the sustainability of one EBP- cognitive-behavioral therapy for chronic pain (CBT-CP) - in the Veterans Health Administration. Changes in provision of CBT-CP after the onset of COVID-19 were examined both qualitatively, using administrative datasets, and qualitatively, through interviews with CBT-CP providers. Changes in total psychotherapy services were also examined for reference. Results indicated CBT-CP provision was substantially disrupted by COVID-19. Interviewees reported difficulties regarding engagement in virtual sessions, disruptions from the home environment, and logistical challenges. Results indicate specific pathways by which the pandemic may have negatively affected the sustainability of this EBP.
Perinatal Outcomes of Monochorionic Twin Pregnancies with Selective Fetal Growth Restriction According to Umbilical Artery Dopplers and Fetal intervention: a Systematic Review and Meta-analysis
Authors: Mustafa Hiba J. , Javinani Ali , Heydari Mohammad-Hossein , Aghajani Faezeh , Saldaña Alexander Vásquez , Rohita Dipesh K. , Khalil Asma 
Published: January 2024

Abstract
Objective
To investigate perinatal outcomes of monochorionic twins complicated by selective fetal growth restriction (sFGR) classified according to umbilical artery (UA) Doppler and type of management including expectant management, fetoscopic laser therapy, and selective reduction of the smaller twin.
Methods
A systematic search was performed in 3 databases until June 2022. The primary outcome was mortality including intrauterine fetal demise (IUFD), neonatal death (NND), and perinatal death (PND), and secondary outcomes were gestational age at birth, birthweight, and neonatal outcomes including survival free from neurological complications (intact survival). Meta-analyses of proportions were used to analyze the extracted data.
Results
27 studies encompassing 354 monochorionic twin pregnancies with type I sFGR, 421 type II sFGR, and 475 type III sFGR were included. In pregnancies with type I sFGR managed expectantly, the smaller twin IUFD occurred in 2% (95% CI 1–6), NND in 2% (95% CI 0–50), while 96% (95% CI 88–99) survived without neurological compromise. In pregnancies with type I sFGR managed with laser, smaller twin IUFD occurred in 12% (95% CI 4–25). In type II sFGR managed expectantly, smaller twin IUFD occurred in 18% (95% CI 1–30), NND in 17% (95% CI 1–26), and 38% (95% CI 22–56) survived without neurological compromise. In pregnancies with type II sFGR managed with laser, smaller twin IUFD occurred in 55% (95% CI 48–63), and 42% (95% CI 3–54) survived without neurological compromise. In type III sFGR managed expectantly, smaller twin IUFD occurred in 16% (95% CI 11–23), NND in 5% (95% CI 3–8), and 62% (95% CI 32–86) survived without neurological compromise. With laser, the smaller twin IUFD occurred in 16% (95% CI 11–23), PND in 63% (95% CI 37–84), and 80% (95% CI 44–97) survived without neurological compromise.
Conclusion
Type I sFGR has low risk of IUFD with expectant management. Type III sFGR had higher morbidity and mortality with laser therapy compared to expectant management. Type II sFGR treated with laser therapy had higher mortality but somehow lower morbidity compared to those managed expectantly, with scarce outcomes data following selective reduction.
Isolation and molecular characterization of the first G8-type sheep rotavirus identified in China
Authors: Li Ping , Gai WenYan , Zhao DengShuai , Zhang DaJun , Yang Xing , Shi XiJuan , Chen LingLing , Zhao MeiYu , Zhao SiYue , Chen GuoHui , He Lu , Yan WenQian , Bei XinTian , Shang YouJun , Zheng HaiXue , Zhang KeShan 
Published: January 2024

Abstract

Objective The objectives were to isolate the Chinese G8 sheep rotavirus and to study some of its genotypic characteristics, to provide basic information for the epidemiological pathology of sheep rotavirus and to provide key biological materials for the study of its pathogenic mechanism. Methods In 2023, anal swabs and small intestinal samples were collected from sheep with clinical manifestations of diarrhea at a Gansu sheep farm. Using RT-PCR, tissue sections, and virus isolation and identification methods, viral infections were investigated in sheep. Results RT-PCR and small intestinal immunohistochemistry confirmed rotavirus infection in the sheep. Rotavirus isolation in MA-104 cells revealed typical cytopathic lesions by the 10th blind transmission generation. Positively identification through indirect immunofluorescence and observation of characteristic 70 nm-sized rotavirus particles in transmission electron microscopy further supported the findings. The capsid protein VP7 and nonstructural protein NSP4 genotypes were identified as G8 and E2, respectively, making the first detection of the G8-type rotavirus in sheep in China. Conclusion This study successfully isolated G8-type sheep rotavirus for the first time in China, contributing valuable date for molecular epidemiological research on sheep rotavirus and providing essential biological materials for further investigations on its pathogenic mechanisms.
Pinpointing the decisive role of TP53 mutations in orchestrating immunosuppression in head and neck squamous cell carcinoma
Authors: Wang Tiansheng , Yuan Jie , Cao Yuxin , Liu Xinrong , Yu Wentao , Zhang Yilei , Liao Feifei , Zhang Chao , Ji Liyan , He Qiongzhi , Gao Lin , Xia Xuefeng , Chu Ling 
Published: January 2024

Abstract
Background
The head and neck squamous cell carcinoma (HNSCC) is the sixth common cancer worldwide and can be affected by multiple etiological factors. The immuno-combination therapies recently demonstrated superior performance but efficient biomarkers for outcome prediction is still lacking. Genetically, TP53 gene demonstrated highest alternation frequency in HNSCC. The lucid elaboration on the interconnections between tumor micro-environment (TME) composition, tumor molecular status and immunotherapy response could benefit HNSCC disease control.
Methods
Multi-omics data for HNSCC including DNA somatic mutation, DNA copy number variation (CNV), RNA expression, DNA methylation as well as patient survival information was collected from The Cancer Genome Atlas (TCGA) project and compared between patients stratified by TP53 mutations. Key discoveries were validated experimentally by patient samples and computationally by public HNSCC cohorts.
Results
The TP53 gene demonstrated top alternation frequency (63%, 298/473) and conferred significant detrimental effect on patient survival. As for expressional analysis, the top down-regulated differentially expressed genes (DEGs) in TP53 mutant group (TP53MT) exhibited power in survival stratification. Interestingly, the CD8+ T cell specifically showed infiltration level diminution in TP53MT group, which was highly correlated with the top DEGs in TP53MT population. Similarly, top CpG sites hypermethylated and the cytoband as well as genes possessing significantly amplified copy number in TP53MT demonstrated the capacity to affect patient survival and strong associations with an immunosuppressive TME. These findings were validated by immunohistochemistry (IHC) method in 14 HNSCC patients and four HNSCC public cohorts.
Conclusions
Our study identified sets of essential molecules altered by TP53 mutational abnormality in HNSCC, which all exhibited strong associations with an immunosuppressive TME. These discoveries provide an unprecedented perspective for HNSCC patient personalized treatment scheme formulation.