bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Intraoperative Conversion from Endovascular to Open vs Planned Open Operation for Abdominal Aortic Aneurysm: A Propensity-Score Matched Study from the American College of Surgeons NSQIP-Targeted Database
Authors: Li Renxi , Sidawy Anton , Nguyen Bao-Ngoc 
Published: February 2024

BACKGROUND:
Evaluating outcomes for acute intraoperative conversion to open surgery during endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) was difficult due to low incidence. This study aimed to compare 30-day outcomes between patients with acute intraoperative conversion during EVAR and planned open surgery, and to identify risk factors associated with acute conversion.

STUDY DESIGN:
Patients who underwent EVAR or planned open AAA repair were identified in American College of Surgeons NSQIP-targeted databases from 2012 to 2021. Patients with acute intraoperative conversion during EVAR were selected. A 1:3 propensity-score matching was used to match demographics, baseline characteristics, surgical indications, aneurysm size and extent, and emergency cases between the conversion open and planned open groups. Thirty-day postoperative outcomes were assessed.

RESULTS:
Of 20,566 EVAR cases, 177 (0.86%) had acute intraoperative conversion to open surgery. The conversion open group was matched to 504 of 5,249 planned open patients. Conversion open and planned open groups had comparable 30-day mortality (23.43% vs 17.46%, p = 0.09) and organ system complications, including major adverse cardiovascular event (14.86% vs 10.71%, p = 0.17), pulmonary complications (17.71% vs 24.01%, p = 0.09), and renal complications (8.57% vs 11.11%, p = 0.39). The conversion open group had lower bleeding requiring transfusion (48.57% vs 75.60%, p < 0.01), shorter operation time (p < 0.01), and shorter length of stay (p < 0.01). Other postoperative outcomes did not differ. Risk factors associated with acute intraoperative conversion included ruptured aneurysm with or without hypotension. Protective factors included hypertension and aortic distal aneurysm extent.

CONCLUSIONS:
Although this study does not endorse a universal “EVAR first” strategy for all patients with AAA, EVAR can be attempted first in eligible patients with AAA. Even when EVAR is unsuccessful, intraoperative conversion to open surgery still appears to be safe compared with planned open repair.
Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system
Authors: Bhore Noopur , Bogacki Erin C. , O'Callaghan Benjamin , Plun-Favreau Helene , Lewis Patrick A. , Herbst Susanne 
Published: February 2024

Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identification of monogenic forms and, more recently, through genome-wide association studies identifying common risk variants. Intriguingly, a number of cellular pathways have emerged from these analysis as playing central roles in the aetiopathogenesis of Parkinson's. In this review, the impact of data deriving from genome-wide analyses for Parkinson's upon our functional understanding of the disease will be examined, with a particular focus on examples of endo-lysosomal and mitochondrial dysfunction. The challenges of moving from a genetic to a functional understanding of common risk variants for Parkinson's will be discussed, with a final consideration of the current state of the genetic architecture of the disorder.
This article is part of a discussion meeting issue ‘Understanding the endo-lysosomal network in neurodegeneration’.
P-type ATPase zinc transporter Rv3270 of Mycobacterium tuberculosis enhances multi-drug efflux activity
Authors: Chatterjee Debasmita , Panda Aditya Prasad , Daya Manasi A. R. , Ghosh Anindya S. 
Published: February 2024

Graphical abstract: The probable model depicting antibiotic export by Rv3270
(a) Antibiotics are reported to enter the cells through porin channels such as Msp family porins .(b) Zn2+ (green dots) imported into the cells through probable Zn2+ importers such as ZIP transporters. (c) Zinc inside the cells may influence the efflux of antibiotics by a co-transportation process through Rv3270 triggered by ATP hydrolysis. (d) Rv3270 possibly captures beta-lactams and extrudes them out of the cells via hypothetical linking proteins (outer membrane efflux adaptor proteins) and porins (Msp family) like AcrAB-TolC and Rv0194. This maintains a lower concentration of the antibiotic inside the cell, reducing its chances of exerting inhibitory effects on cell wall synthesis.
Orthogonal neural representations support perceptual judgements of natural stimuli
Authors: Srinath Ramanujan , Ni Amy M. , Marucci Claire , Cohen Marlene R. , Brainard David H. 
Published: February 2024

AbstractIn natural behavior, observers must separate relevant information from a barrage of irrelevant information. Many studies have investigated the neural underpinnings of this ability using artificial stimuli presented on simple backgrounds. Natural viewing, however, carries a set of challenges that are inaccessible using artificial stimuli, including neural responses to background objects that are task-irrelevant. An emerging body of evidence suggests that the visual abilities of humans and animals can be modeled through the linear decoding of task-relevant information from visual cortex. This idea suggests the hypothesis that irrelevant features of a natural scene should impair performance on a visual task only if their neural representations intrude on the linear readout of the task relevant feature, as would occur if the representations of task-relevant and irrelevant features are not orthogonal in the underlying neural population. We tested this hypothesis using human psychophysics and monkey neurophysiology, in response to parametrically variable naturalistic stimuli. We demonstrate that 1) the neural representation of one feature (the position of a central object) in visual area V4 is orthogonal to those of several background features, 2) the ability of human observers to precisely judge object position was largely unaffected by task-irrelevant variation in those background features, and 3) many features of the object and the background are orthogonally represented by V4 neural responses. Our observations are consistent with the hypothesis that orthogonal neural representations can support stable perception of objects and features despite the tremendous richness of natural visual scenes.Significance StatementWe studied how the structure of the mid-level neural representation of multiple visual features supports robust perceptual decisions. We combined array recording with parametrically controlled naturalistic images to demonstrate that the representation of a central object’s position in monkey visual area V4 is orthogonal to that of several background features. In addition, we used human psychophysics with the same stimulus set to show that observers’ ability to judge a central object’s position is largely unaffected by variation in the same background features. This result supports the hypothesis that orthogonal neural representations can enable stable and robust perception in naturalistic visual environments and advances our understanding of how visual processing operates in the real world.
Infusing structural assumptions into dimensionality reduction for single-cell RNA sequencing data to identify small gene sets
Authors: Hackenberg Maren , Brunn Niklas , Vogel Tanja , Binder Harald 
Published: February 2024

AbstractDimensionality reduction greatly facilitates the exploration of cellular heterogeneity in single-cell RNA sequencing data. While most of such approaches are data-driven, it can be useful to incorporate biologically plausible assumptions about the underlying structure or the experimental design. We propose the boosting autoencoder (BAE) approach, which combines the advantages of unsupervised deep learning for dimensionality reduction and boosting for formalizing assumptions. Specifically, our approach selects small sets of genes that explain latent dimensions. As illustrative applications, we explore the diversity of neural cell identities and temporal patterns of embryonic development.
Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells
Authors: Tourneur Adrien , Rodrigues Vitória Joel , Saiselet Manuel , Craciun Ligia , Larsimont Denis , Lefort Anne , Libert Frederick , Maenhaut Carine , Costagliola Sabine , Tarabichi Maxime , Romitti Mirian , Detours Vincent 
Published: February 2024

AbstractSixty percent of papillary thyroid cancers (PTCs) are driven byBRAFV600E,a mutation associated with high inter- and intra-tumoral heterogeneity. PTCs may become highly aggressive anaplastic thyroid cancers (ATC). While single cell transcriptomics may resolve this heterogeneity, it is potentially confounded by batch effects whose correction may dampen inter-tumor variations. We profiled ATCs andBRAFV600EPTCs with single nuclei RNA-seq and spatial transcriptomics, and an experimental design disentangling biological and technical variations. It reveals that much transcriptional variation in cancer cells and several immune cell types is idiosyncratic, i.e. tumor-specific. It is associated in some cases with genomic aberrations and global tissue states like hypoxia. Beyond idiosyncrasies, differentiation markersSLC5A5 (N/S), TPO, TGandTSHRare lost in a sequence mirrored by their gain during human thyroid organoids maturation, suggesting a new classification of cancer cell states. PTC cells retainTSHRexpression and show features of partial EMT with a massive expression ofFN1,which promotes proliferation via an autocrine loop. In contrast, ATCs undergo full blown EMT, with expression of mesenchymal extracellular components and loss ofTSHR.Finally, we show that the microenvironment of cancer cells is driven by inflammation. These findings may help future stratifications ofBRAFV600EPTCs.
Mapping Spatial Patterns to Energetic Benefits in Groups of Flow-coupled Swimmers
Authors: Heydari Sina , Hang Haotian , Kanso Eva 
Published: February 2024

AbstractThe coordinated motion of animal groups through fluids is thought to reduce the cost of locomotion to individuals in the group. However, the connection between the spatial patterns observed in collectively moving animals and the energetic benefits at each position within the group remains unclear. To address this knowledge gap, we study the spontaneous emergence of cohesive formations in groups of fish, modeled as flapping foils, all heading in the same direction. We show in pairwise formations and with increasing group size that (1) in side-by-side arrangements, the reciprocal nature of flow coupling results in an equal distribution of energy re-quirements among all members, with reduction in cost of locomotion for swimmers flapping inphase but an increase in cost for swimmers flapping antiphase, and (2) in inline arrangements, flow coupling is non-reciprocal for all flapping phase, with energetic savings in favor of trailing swimmers, but only up to a finite number of swimmers, beyond which school cohesion and energetic benefits are lost at once. We explain these findings mechanistically and we provide efficient diagnostic tools for identifying locations in the wake of single and multiple swimmers that offer op-portunities for hydrodynamic benefits to aspiring followers. Our results imply a connection between the resources generated by flow physics and social traits that influence greedy and cooperative group behavior.
Long-term evolution experiments fully reveal the potential for thermal adaptation
Authors: Antunes Marta A. , Grandela Afonso , Matos Margarida , Simões Pedro 
Published: February 2024

AbstractGlobal warming is leading to worldwide biodiversity decline at a fast pace. Evolutionary responses may be crucial in allowing organisms to cope with prolonged effects of climate change. This urges the need for a better understanding of the dynamics of adaptation to warming environments. In particular, addressing how reproductive success evolves in deteriorating environments is extremely relevant, as this trait is more likely constrained at lower temperatures than upper physiological thermal limits. Experimental evolution under a warming environment can elucidate the potential of populations to respond to rapid environmental changes. The few studies following such framework lack analysis of long-term response. We here focus on the long-term thermal evolution of twoDrosophila subobscurapopulations, from different European latitudes, under warming temperatures. We estimated the reproductive success of these populations in two test environments: the ancestral (control) and the warming environment after 39 and 52 generations of thermal evolution. We found that a relevant long-term adaptive response to warming temperatures can occur, but the pace of such response is slow. In addition, we observed contrasting responses in the ancestral environmental and differences in the evolutionary dynamics between populations of distinct histories, with those originally from higher latitude only showing an adaptive response under the to the warming environment regime in at a later generation. This study reinforces the need for long-term evolution experiments to fully reveal the potential for thermal response. It also highlights that the scrutiny of several populations in this context is needed for a measure of variation within a species. Accounting for these sources of variation - both temporal and spatial - will allow for more robust assessments of climate change responses.
Molecular response to multiple trace element contamination of the European sardine
Authors: Beauvieux Anaïs , Fromentin Jean-Marc , Saraux Claire , Romero Diego , Couffin Nathan , Brown Adrien , Metral Luisa , Bertile Fabrice , Schull Quentin 
Published: February 2024

ABSTRACTIn marine ecosystems, the presence of trace elements resulting from anthropogenic activities has raised concerns regarding their potential effects on marine organisms. This study delves into the intricate relationship between trace element contamination and the physiological responses of a key marine species in the Mediterranean Sea: the European sardine. Since 2008, this species has been experiencing a significant crisis in the region, prompting numerous studies to investigate the potential factors behind the dramatic decline in sardines’ size, age, and body condition. However, thorough information on chemical contamination by trace elements and its physiological impact on this species was lacking. We found evidence for the accumulation of multiple elements in sardines, with a light East-West contamination gradient within the Gulf of Lions. While macro-physiological parameters (i.e. body condition) were not affected by contamination, pathways involved in cellular organization and response to stress were clearly upregulated, particularly in the liver, but also in muscle. In addition, a global upregulation in processes linked to the immune system, lipid homeostasis and oxidative stress was recorded in the liver. The associated energetic cost may add a substantial burden to sardines that already face multi-factorial constraints. This study also allows to pinpoint biomarkers of exposure and effects that may be important for monitoring Mediterranean sardine’s health. The results of this study and particularly the complex changes in protein expression demonstrate the need for future studies to test the concomitant effects of multiple stressors acting simultaneously, including large scale contamination.
Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease
Authors: Li Yujia , Huang Chenjun , Fan Weiguo , Hammad Seddik , Berger Lea , Géraud Cyrill , Yao Ye , Link Frederik , Tong Chenhao , Nwosu Zeribe C. , Erdösi Pia , Piorońska Weronika , Gould Kerry , Meyer Christoph , Feng Rilu , Liu Hui , Shao Chen , Sun Bing , Ding Huiguo , Liebe Roman , Ebert Matthias P. A. , Weng Honglei , Gao Chunfang , ten Dijke Peter , Dooley Steven , Wang Sai 
Published: February 2024

AbstractIn healthy livers, extracellular matrix protein 1 (ECM1) is essential for liver homeostasis by keeping latent transforming growth factor-β (LTGF-β) quiescent. Upon hepatocyte damage, ECM1 is downregulated, facilitating LTGF-β activation and fibrogenesis. However, little is known about how hepatic ECM1 is regulated. Here we found in healthy hepatocytes, EGF/EGFR signaling sustains ECM1 expression through phosphorylating STAT1 at S727, enhancing its binding to theECM1promoter and boosting gene transcription. During liver inflammation, accumulating IFNγ disrupts this process by downregulating EGFR and inhibiting EGF/EGFR/STAT1-mediatedECM1promoter binding. Mechanistically, IFNγ-induced STAT1 phosphorylation at Y701 impairs the binding of p-STAT1 S727 to the ECM1 promoter. Additionally, IFNγ induces NRF2 nuclear translocation, which repressively binds to theECM1promoter, further reducing its expression. These findings were confirmed in several chronic liver disease (CLD) mouse models. Moreover, AAV8-ECM1 significantly attenuates liver fibrosis and injuries in Western diet (WD)-fed mice. Notably, in patients with CLD, ECM1 levels align with EGFR expression, while NRF2 and LTGF-β activation show a negative correlation with both.
When the goose stops laying golden eggs: supervening loss of trust in long-term contracts under the PICC
Authors: Mohamed Hassan 
Published: February 2024

Purpose
The purpose of this paper is to examine the supervening loss of inter-organisational trust in long-term commercial contracts. The underlying research question is whether contract law – the legal institution regulating economic exchanges – should intervene and enable a party to a long-term commercial contract to extricate itself from a situation where a relationship of trust has broken down irretrievably.

Design/methodology/approach
This paper uses doctrinal methodology and theoretical conceptualisation to answer the underlying research question. The legal instrument chosen for analysis purposes is the UNIDROIT Principles of International Commercial Contracts. This paper also draws on extant literature on inter-organisational trust (including conceptual and empirical studies) to support the arguments and propositions. Furthermore, this study proceeds to assess the substantive justifiability of the proposed remedial measure using four normative values: legal certainty and predictability, protection of the performance interest, economic efficiency and the preservation of the relation.

Findings
The central argument put forward in this paper is the reformulation of draft Article 6.3.1 proposed by the UNIDROIT Working Group on Long-Term Contracts, which confers a novel right to terminate for a compelling reason. This paper presents a multidimensional model of inter-organisational trust that would serve as the conceptual framework for the proposed reformulation of the provision and establishes a coherent juridical basis for the legal solution that would accord with the Principles of International Commercial Contracts’ general remedial scheme. As for the normative assessment, this paper demonstrates that the proposed remedial measure would significantly promote efficient outcomes and positively serve the norms of legal certainty, protection of the performance interest and the preservation of the relation.

Originality/value
This paper addresses the lacuna in current legal scholarship in relation to the adverse socio-economic effects following trust violation and deterioration in inter-organisational relationships. Additionally, the propositions and findings should contribute to the workings of the UNIDROIT in adopting new rules and principles that would serve the special requirements of cross-border trade.
Leader’s paradox mindset, organisational change capability, and performance: a multi-level analysis
Authors: Supriharyanti Elisabeth , Sukoco Badri Munir , Widianto Sunu , Soparnot Richard 
Published: February 2024

Purpose
This study aims to propose a multi-level (bottom-up) analysis to build an organizational change capability (OCC) development model by integrating paradox and social cognitive theories. Using these theories, OCC (Level 2) is influenced by the leader’s paradox mindset (Level 1) and collective PsyCap (Level 2). The study also examined the moderating effect of magnitude to change on the effect of leader’s paradox mindset on OCC.

Design/methodology/approach
The proposed hypotheses were tested empirically using data from 327 respondents and 48 work teams from 21 leading private higher education institutions in Indonesia. To analyze the data, a multi-level analysis was conducted with Mplus software.

Findings
The results showed that, in a cross-level relationship, leader’s paradox mindset had a positive effect on OCC, whereas OCC mediated the effect of leader’s paradox mindset on organizational change performance. On an organizational level, collective PsyCap affected OCC, and OCC significantly mediated the relationship between collective PsyCap and organizational change performance. Moreover, the authors found a moderating effect of magnitude on change of leader’s paradox mindset to OCC.

Originality/value
This study used a multi-level analysis to evaluate the mechanisms of influence of leader’s paradox mindset (bottom-up) on OCC and the moderation effect of magnitude to change in an Indonesian context.
Looking at the relationship between growth and profitability: the role of cost stickiness as a strategic liability
Authors: Lefebvre Vivien 
Published: February 2024

Purpose
This paper aims to revisit the relationship between sales growth and profitability by exploring the direct and indirect effects of cost stickiness in the growth process. Cost stickiness refers to asymmetric variations of costs associated with increases and decreases in sales. Cost stickiness is analyzed as a strategic liability that negatively affects profitability because it contributes to organizational rigidity that causes opportunity costs.

Design/methodology/approach
The empirical design is based on a large sample of 65,599 French firms drawn from the Amadeus database and it covers the period 2010 to 2019. The authors take advantage of the presentation of expenses made by nature in Amadeus to calculate cost stickiness in a more direct way than what is commonly done in the literature. The authors use various regression models to test the hypotheses.

Findings
For firms that experience rapid growth in sales, cost stickiness has a positive moderating effect on the relation between sales growth and profitability because of a higher asset turnover efficiency. However, for firms that experience slow growth, no growth or a decrease in sales, cost stickiness plays a negative moderating effect on the relation between sales and profitability.

Originality/value
This work contributes to the discussion about the conditions under which high growth is associated with greater profitability and conceptualizes cost stickiness as a strategic liability. The empirical context, privately held firms, has been overlooked by previous research.