bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the causal relationship between ankylosing spondylitis and common andrological diseases based on Mendelian randomization
Authors: Liu Wenbang , Zhang Chenming , Ma Sicheng , Hu Jing , Ma Ruimin , Hao Xiaohui , Yu Wenlin , Zhang Lishuo , Cui Hehe 
Published: October 2023

Abstract
Objective: This study was designed to analyze the causal relationship between ankylosing spondylitis and common male diseases (male infertility, prostatic hyperplasia, prostatitis, erectile dysfunction, orchitis and epididymitis, sexual dysfunction and sperm cyst) using Mendelian randomization and to provide suggestions for clinical prevention and treatment.
Methods and materials: A summary dataset of genome-wide association studies was used for the method study. Mendelian randomization was performed using inverse variance weighting, weighted median, and MR‒Egger regression analysis to assess the causal relationship between ankylosing spondylitis and common andrological diseases. Heterogeneity was tested using the Cochran Q method, pleiotropic properties were tested using the MR‒Egger and MR-PRESSO methods, and sensitivity was tested using the leave-one-out method.
Results: The results showed that the risk of male infertility in patients with ankylosing spondylitis was 2.389 times that in patients Non-ankylosing spondylitis (OR=2.389, 95% CL: 1.334–4.278, P=0.034), and the risk of prostatic hyperplasia was correspondingly increased (OR=1.260, 95% CL: 1.057–1.501, P=0.009), without a significant causal relationship with other common male diseases. The results of the MR‒Egger analysis and the weighted median method were not significant. The results from the Cochran Q method showed no heterogeneity of the included SNPs. The results from the MR‒Egger and MR-PRESSO methods indicated that there was no horizontal pleiotropic effect between exposure and outcome variables. The results of the sensitivity analysis with the one-stay method were stable, and no strong impact of SNP sites in instrumental variables on the results was detected.
Limitations: Additional research is imperative.
Conclusion: There is a positive causal relationship between ankylosing spondylitis and male infertility, and benign prostate hyperplasia. Suffering from ankylosing spondylitis will increase the risk of male infertility and BPH.
Human Parathyroid Hormone (1-34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1
Authors: Sun Qingpeng , Zhou Liya , Yu Zhiyong , Zhang Jun , Zhang Chao , Pi Honglin 
Published: October 2023

Abstract
Delayed wound healing is a public issue that imposes a significant burden on both society and the patients themselves. To date, although numerous methods have been developed to accelerate the speed of wound closure, the therapeutic effects are partially limited due to the complex procedures, high costs, potential side effects, and ethical concerns. While some studies have reported that the in-vivo application of Human Parathyroid Hormone (1–34) (hPTH(1–34)) promotes the wound-healing process, the definitive role and underlying mechanisms through which it regulates the behavior of fibroblasts and keratinocytes remains unclear. Herein, hPTH(1–34)’s role in cell migration is evaluated with a series of in-vitro and in-vivo studies, whereby hPTH(1–34)’s underlying mechanism in activating the two types of cells was detected. The in-vitro study revealed that hPTH(1–34) enhanced the migration of both fibroblasts and HaCaT cells. Ras-associated C3 botulinum toxin subunit 1 (Rac1), a classical member of the Rho family, was upregulated in hPTH(1–34)-treated fibroblasts and HaCaT cells. Further study by silencing the expression of Rac1 with siRNA reversed the hPTH(1–34)-enhanced cell migration, thus confirming that Rac1 was involved in HPTH(1–34)-induced cell behavior. In-vivo study on rat wound models confirmed the effects of hPTH(1–34) on fibroblasts and keratinocytes, with increased collagen deposition, fibroblasts accumulation, and Rac1 expression in the hPTH(1–34)-treated wounds. In summary, the present study demonstrated that hPTH(1–34) accelerated wound healing through enhancing the migration of cells through the up-regulation of Rac1 expression.
Detailed Cloud Linear Regression Services in Cloud Computing Environment
Authors: Seno Mohammed E. , Mohammad Omer Jasim , Dhannoon Ban 
Published: October 2023

Abstract
This paper presents a novel cloud-based machine learning framework centered around a linear regression method known as Cloud Linear Regression (CLR). CLR combines elements of cloud technology and machine learning principles. Furthermore, it explores the connection between cloud task scheduling, distribution, and machine learning methodologies, showcasing how linear regression techniques play a pivotal role in enhancing the cloud environment. CLR demonstrated it is effectiveness in dealing with expansive environments that have big data by exhibiting high thorough mining for the best resource predictive accuracy and response times, it has been applied to three scenarios for the best CPU accuracy utilization of the prediction which was (45%), (53.44%), and (59.81%) respectively. Moreover, CLR offers an efficient remedy for managing resources, including task scheduling, provisioning, allocation, and ensuring availability. CLR obtained the highest performance of (40%) with multitasking resources, (72%) with Memory utilization, (90% with logical Disk utilization, and (30%) with Bandwidth utilization.
Improving the flame retardancy and smoke suppression of PVC membrane material by incorporating zinc borate-modified diantimony trioxide
Authors: Zhang Bin , Zeng Shaohua 
Published: October 2023

Abstract
Zinc borate (ZB) based diantimony trioxide(Sb2O3) are environment-friendly flame retardant for flexible PVC membrane material. Also, they usually exhibit high flame retardancy and smoke suppression properties. The maximum LOI value of PVC/20 wt% ZB-Sb2O3 membrane material reached 37.5% and passed the UL 94 V-0 rating. An obvious synergistic effect between ZB and Sb2O3 was observed by LOI, SDR and TG. Moreover, remarkable decreases in the smoke density were observed when ZB-Sb2O3 was incorporated into PVC. The addition of ZB and Sb2O3 greatly increased the amount of residual char and apparently improved the mechanical properties of PVC membrane material. Additionally, the structure and morphology of the residual chars have been studied by FTIR, EDX and SEM. The results illustrated that the flame retardancy of ZB-Sb2O3 was mainly exerted in the condensed phase.
Association of Childhood Adversities on the Persistence and Remission of Drug-Naïve Attention-Deficit/Hyperactivity Disorder in a Longitudinal Community-Based Sample
Authors: Salo Mikko , Hurtig Tuula , Nordström Tanja , Veijola Juha , Halt Anu-Helmi 
Published: October 2023

Abstract
Objective: To investigate the influence of Adverse Childhood Experiences (ACEs) on the natural course of attention-deficit/hyperactivity disorder (ADHD) without the effect of ADHD medication.
Method: 457 Finnish children (261 cases, 196 controls) partook in a clinical study where their ADHD trajectory was defined from the age of 7 to the age of 16. Using binary logistic regression analysis with psychiatric comorbidities and sex as confounders we studied the association of ACEs to this trajectory.
Results: The analysis identified a statistically significant association between high ACE scores and a partially remitting ADHD trajectory (Odds Ratio=2.07, 95 % Confidence Intervals=1.26-3.38, p=.004).
Conclusions: A high ACE score showed an association with having some persistent ADHD symptoms in adolescence while not reaching the diagnostic threshold for ADHD in the partially remitting group. This is a novel finding, and further studies with larger samples would be needed to replicate and extend these preliminary findings.
The causal relationship between depression and low back pain: a two-sample Mendelian randomized study
Authors: Liu Min , Liu Meinian , Peng Guanrong , Yang Wenlong , Yang Fengyun , Yang Zhijun , Zeng Yirong 
Published: October 2023

Abstract
Background
Mendelian randomization analysis was employed to examine the potential causal link between depression and low back pain. This analysis utilizes genetic variants as instrumental variables to help establish a causal relationship. By leveraging the genetic variants associated with depression as the exposure factor, the study aimed to investigate whether there is a causal effect on the development or severity of low back pain. This approach provides valuable insights into the potential causal association between these two conditions.
Methods
The entire Gene Association Study database (GWAS) was utilized for data mining in a study aiming to investigate the relationship between depression as the exposure factor and low back pain as the outcome factor. Mendelian randomization analysis was performed using regression models such as inverse variance weighting (IVW), the MR‒Egger method, the simple mode method, the weighted median method, and the weighted mode method. The objective was to uncover any potential causal relationship between the exposure factors and the outcome.
Results
In this study, a total of 25 single nucleotide polymorphism (SNP) loci were utilized as instrumental variables to assess the causal association between depression and low back pain. The inverse variance weighting method estimated that individuals with depression had a 1.71 times higher risk (OR) of experiencing low back pain than the healthy population (95% CI: 1.258 to 2.332, p=0.0006). Similarly, the weighted median method also supported a causal effect between depression and low back pain (95% CI: 1.180 to 2.789, p = 0.0007). Tests for heterogeneity using the inverse variance weighting and MR‒Egger regression methods indicated no significant heterogeneity. Furthermore, the MR‒Egger regression intercept terms and MRPRESSO method tests suggested that the results were less likely to be influenced by genetic pleiotropy. Leave-one-out analyses did not identify any nonspecific SNPs that unduly influenced the results. Overall, these findings provide stronger evidence for a causal relationship between depression and low back pain.
Conclusions
There may be a positive causal association between depression and low back pain.
Enhancement of the electrochemical performance of LiNi0.5Mn1.5O4 cathode materials for Li-ion battery by Mo-Fco-doping
Authors: Weng Yuling , Zhang Hailang L. 
Published: October 2023

Abstract
The pristine LiNi0.5Mn1.5O4 (LNMO) and Mo-F co-doped LiNi0.5Mn1.5O4 spinel materials were prepared via a rheological phase method. The four samples were analyzed by X-ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and X-ray photoelectron spectroscopy (XPS). Compared with the pristine LNMO sample, Mo-F co-doped LNMO materials could increase the lattice parameters, reduce particle sizes, increase Mn3+ contents, and significantly improve the electrochemical performances of LNMO. The doped material exhibited optimum electrochemical properties when the Mo and F doping amounts are 1% and 3% ,respectively, denoted as Mo/F-2. The discharge capacity retention of Mo/F-2 is 95.6%, which is higher than the pristine sample (87.7%) after 100 cycles at 1C and room temperature. Furthermore, the discharge-specific capacity of the Mo/F-2 sample reaches 113.4 mAh g− 1 at 5C, while the pristine sample reaches only 61.9 mAh g− 1. After CV and EIS analysis, it was found that the Mo-F co-doped LNMO materials had better Li+ diffusion kinetics than the pristine LNMO sample. Thus, Mo-F co-doping is considered an effective modification method for LNMO cathode material.
8000-6000 year-old anthropically broken stalagmite structures up to 2km deep in the cave of Saint-Marcel, France: Traversing and using underground caves during the Early Holocene.
Authors: Delannoy Jean-Jacques , Kemper Jules , Jaillet Stephane , Pons-Branchu Edwige , Vandevelde Ségolène , Dupuy Delphine , Dapoigny Arnaud 
Published: October 2023

Abstract
The cave of Saint-Marcel is known for its extensive network (64 km of galleries) and its history of human occupation (Middle Paleolithic and Neolithic) in the entrance area. Close observation of the main network reveals areas with high concentrations of broken speleothems, which are usually attributed to the first tourist visits of the 19th century. However, archaeo-geomorphological mapping of the broken speleothems, many of which are lying on the floor and sealed by stalagmite regrowth or crust, indicates intentional organisation of the underground space into speleothem supply zones and zones in which the speleothems were used to build structures. Age estimates of the stalagmite seals on these human-made structures suggest that the structures were a result of human activity that occurred between the end of the Upper Palaeolithic and the European Mesolithic. These age estimates radically change the way we look at the broken speleothems in the cave of Saint-Marcel and the structures associated with them. They bring to light the engagement of past human communities with the deep underground environment, at more than 1.5 km from the cave entrance, which can only be accessed by crossing obstacles (pits) that are considered to be difficult to cross today. Our findings as well as ongoing research highlight the unequivocal archaeological significance of the cave.
The effect of noisy environment on secure quantum teleportation of uni-modal Gaussian states
Authors: Isar Aurelian , Mehrabankar Somayeh , Abbasnezhad Farkhondeh , Afshar Davood , Mahmoudi Payman 
Published: October 2023

Abstract

Quantum communication networks rely on quantum teleportation, a process where an unknown quantum state is transmitted between sender and receiver via entangled states and classical communication. In our study, we utilize a continuous variable two-mode squeezed vacuum state as the primary resource for quantum teleportation, shared by Alice and Bob, while exposed to a squeezed thermal environment. Secure quantum teleportation necessitates a teleportation fidelity exceeding 2/3 and the establishment of two-way steering of the resource state. We investigate the temporal evolution of steering and teleportation fidelity to determine critical parameter values for secure quantum teleportation of a coherent Gaussian state. Our findings reveal constraints imposed by temperature, dissipation rate, and squeezing parameters of the squeezed thermal reservoir on the duration of secure quantum teleportation. Intriguingly, we demonstrate that increasing the initial state’s squeezing parameter effectively extends the temporal window for successful secure quantum teleportation.
Identification of Immune-Related Genes and Construction of Metastasis Prediction Model for Non-Small Cell Lung Cancer
Authors: LIAO Zhixiao , Zhou Jingxu , Xia Rui , Zhu Jinli , Jia Yingjie , Deng Yueyang 
Published: October 2023

Abstract
Objective: The aim of the study was to identify the immune-related genes (IRGs) associated with non-small cell lung cancer (NSCLC) metastasis, and establish a risk score prediction model.
Methods: Gene expression information and clinical data of NSCLC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were screened based on tumor group and normal group. DEGs were intersected with IRGs from the ImmPort database to obtain differentially expressed IRGs (DEIRGs). Weighted gene coexpression network analysis (WGCNA) was applied to determine the hub DEIRGs (HubDEIRGs) related to immune scores. Risk score was calculated based on the significant HubDEIRGs through logistic regression analyses. Logistic regression analysis was performed to analyze the influencing factors for metastasis with age, gender, T stage and risk score as covariates. A metastasis risk nomogram was constructed. The correlation between risk score and immune cells infiltration was examined.
Results: A total of 477 HubDEIRGs were identified. PDK1, PROC, IL11, SH2D1B, S100A5, AGT, WFDC2, CRHR2 and EREG were metastasis-associated immune genes. Age, T stage and risk score served as independent risk factors for metastasis. The areas under the curve (AUC) of the nomogram were 0.714 and 0.643 in the training and validation sets. The calibration curve was close to the ideal diagonal line. The high-risk group had a greater degree of immune infiltration than the low-risk group.
Conclusion: The risk scoring model for predicting the risk of metastasis in NSCLC patients based on 9 immune genes in this study had importantly potential clinical application value.
Preventing abuse and enhancing mental health among infertile couples: results of a pre/post pilot test of the use of cognitive behavior therapy among fertility service seekers in Jordan
Authors: Clark Cari Jo , Al-Hamdan Zaid , Bawadi Hala , Alsalem Hussein , Hamadneh Jehan , Al-Haija Adnan Abu , Hadd Alexandria Ree , Spencer Rachael A. , Bergenfeld Irina , Hall-Clifford Rachel 
Published: October 2023

Abstract

Introduction
Infertility increases women’s risk of intimate partner violence (IPV). Cognitive behavioral therapy (CBT) is commonly used to treat mental health problems among fertility treatment seeking patients. CBT has not been tested for its potential to reduce IPV in this population. We pilot test the use of CBT to prevent IPV and improve patients' mental health in a fertility clinic in Jordan.
Methods
Of 38 eligible fertility-treatment seeking couples, 16 consented and underwent up to 11 CBT sessions (average = 9) over 3 months. Interviews at baseline and 16 weeks post intervention (endline) assessed IPV, quality of life, social support, coping, and fear of spouse. Wilcoxon signed-rank and McNemar’s tests were used to assess change in outcomes.
Results
At baseline, women's rates of IPV, depression, and anxiety were 75%, 87.5%, and 75% respectively, whereas men's rates of depression and anxiety were each 80%. Average baseline post-traumatic stress disorder (PTSD) symptoms for men and women were 3.3 and 2.7 respectively out of 5. IPV decreased 25% after treatment, and women reported less spousal fear. For both men and women, depression, anxiety, and PTSD symptoms decreased and social support and fertility quality of life improved.
Conclusion
Psychosocial support should be standard of care for the treatment of infertility given the burden of mental health problems and IPV and the utility of CBT in this patient population. Co-design with couples is needed to identify strategies to bolster participation along with population-based interventions to combat the stigma of infertility and mental health service use and enhance women's status.
A Deep Reinforcement Learning-Based Multi-Resource Pricing Game in Computing Power Network
Authors: Huang Xiaojie , Xu Fangmin , Zhao cheng , Wang Zhuwei , Chen Xiaomin 
Published: October 2023

Abstract

Computing Power Network (CPN) integrates network, computing and storage resources to achieve efficient collaboration of cloud, edge and end, and meet the industry's demand for highly differentiated computing services. In contrast to fixed pricing, dynamic pricing allows mobile users (MUs) to request and pay for resources based on their demands. Resource providers (RPs) meet the needs of MUs through personalized network services and benefit from differentiated pricing. Traditional edge computing is limited to study the pricing of single resource, but the integration of multiple resources in CPN makes the scene more complex. To address this problem, we propose a multi-leader multi-follower Stackelberg game model for the dynamic pricing of multiple resources problem between RPs acting as leaders and MUs acting as followers. Specifically, we first give the initial unit price announced by RPs, MUs use the trust region method to solve the optimal purchase amount of computing resources and communication resources. After that, each leader observes the request and iteratively adjusted the pricing strategy based on the Multi-Agent Deep Deterministic Policy Gradient (MADDPG). Simulation results show that stakeholders' benefits in multi-resource pricing are better than that in single-resource pricing.
The effect of topological design on the degradation behavior of additively manufactured porous zinc alloy
Authors: Li Yageng , Shi Yixuan , Xu Wei , Che Haodong , Zhao Shangyan , Chang Weiwei , Li Xuan , Lu Yuchen , Xue Chenran , Zhang Dawei , Wang Luning 
Published: October 2023

Abstract

The advent of additively manufactured biodegradable porous metals presents a transformative opportunity to meet the criteria of ideal bone substitutes. Precisely tailoring their degradation behavior constitutes a pivotal aspect of this endeavor. In this study, for the first time, we investigated the effects of topological designs on the degradation profile of laser powder bed fusion (LPBF) Zn scaffolds under dynamic in vitro immersion tests. Specifically, four types of Zn-0.4Mn-0.2Mg scaffolds (beam-based: diamond, face center cubic; surface-based: gyroid, schwarz-P) were designed and fabricated. The degradation mechanism of the scaffolds was comprehensively evaluated using both experimental and simulation methods. The results illuminate the profound impact of structural design on the degradation properties of the Zn alloy scaffolds. The beam-based diamond and face center cubic scaffolds exhibited a degradation rate of 0.5–0.8 mm/year with a relatively uniform degradation mode under dynamic immersion. On the contrary, the surface-based gyroid and Schwarz-P scaffolds demonstrated a notably reduced degradation rate due to lower permeability. This restricted the diffusion of medium ions within the pores, culminating in the accumulation of degradation products and more severe localized degradation. This study underscores the potential of topological design as a compelling strategy for tailoring the degradation profile of additively manufactured biodegradable scaffolds, thereby advancing their suitability as bone substitutes.
The Potential Efficacy of Artemisia Anuua L. Extract Nanoparticles in Mitigating Obesity-Related-Metabolic Complications in Hypercaloric Diet-Fed Rats
Authors: Mohameda Maha M. , Mohamed Enas Ali Kamel 
Published: October 2023

Abstract
Obesity-related health problems are getting worse in various societies worldwide. Artemisia anuua L. (AA) has distinctive health benefits, including anti-inflammatory, antioxidant, and insulin-sensitizing properties; however, its major constituents' limitedsolubility and bioavailability constrain its absorption. This study aimed to use a sonochemical technique to nano-formulate the AA ethanolic extract (AAE) to produce AAE nanoparticles (AAEN) and to compare their efficacy in modulating obesity-related complications in hypercaloric (high-fat /high-sucrose, HF/HS) diet-induced obese rats. Forty-eight Sprague Dawley adult rats were divided into two main groups and fed a basal or hypercaloric diet for twelve weeks. Starting from the eighth week, each main group was subdivided into three subgroups and treated orally with either saline, AAE, or AAEN till the end of the experiment (12 weeks). AAE and AAEN exerted antiadipogenic effects. They reduced body weight and epididymal fat, mitigated dyslipidemia, improved glucose utilization, reduced insulin resistance and hyperleptinemia, increased serum adiponectin, and decreased oxidative stress andinflammatory markers. These results were mediated by controlling the expression of critical genes contributing to lipids and carbohydrate metabolism.AAEN produced more expressive ameliorating effects than the conventional extract. In conclusion, nanoformulation of Artemisia annua L. extract boosted its antiadipogenic efficacy.