bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framework for Analyzing Human Cognition in Operationally-Relevant Human Swarm Interaction
Authors: Distefano Joseph P. , Cho Hanvit , Krisshnakumar Prajit , Chowdhury Souma , Esfahani Ehsan 
Published: November 2023

Abstract
For a wide variety of envisioned humanitarian and commercial applications that involve a human user commanding a swarm of robotic systems, developing human-swarm interaction (HSI) principles and interfaces calls for systematic virtual environments to study such HSI implementations. Specifically, such studies are fundamental to achieving HSI that is operationally efficient and can facilitate trust calibration through the collection-use-modeling of cognitive information. However, there is a lack of such virtual environments, especially in the context of studying HSI in different operationally relevant contexts. Building on our previous work in swarm simulation and computer game-based HSI, this paper develops a comprehensive virtual environment to study HSI under varying swarm size, swarm compliance, and swarm-to-human feedback. This paper demonstrates how this simulation environment informs the development of an indoor physical (experimentation) environment to evaluate the human cognitive model. New approaches are presented to simulate physical assets based on physical experiment-based calibration and the effects that this presents on the human users. Key features of the simulation environment include medium fidelity simulation of large teams of small aerial and ground vehicles (based on the Pybullet engine), a graphical user interface to receive human command and provide feedback (from swarm assets) to human in the case of non-compliance with commands, and a lab-streaming layer to synchronize physiological data collection (e.g., related to brain activity and eye gaze) with swarm state and human commands.
Efficient Robust Design Space Visualization and Exploration for Many-Objective Problems – A Vehicular Crashworthiness Example
Authors: Balaji Niharika , Baby Mathew , Sharma Gehendra , Rama Sushil Rashmi , Ramu Palaniappan , Nellippallil Anand Balu 
Published: November 2023

Abstract
The design of vehicular components is often complicated by the presence of many conflicting goals, such as improved energy absorption for safety, mass reduction for increased fuel economy, and so on. The uncertainties associated with the manufacturing processes involved in realizing the components impact vehicular performance. Hence, the design of vehicular components needs to account for many conflicting goals and associated uncertainties to ensure performance. We look at managing the uncertainties involved by exploring the design space and seeking a ranged set of ‘satisficing robust solutions’ that are relatively insensitive to uncertainties while still meeting the requirements of the designers.
In this paper, we present a robust design exploration framework that combines the robust concept exploration framework with a machine learning-based visualization technique called interpretable Self-Organizing Map (iSOM) to support the design exploration and visualization for problems with many (more than three) conflicting goals. In the framework presented, we examine uncertainty associated with the design variables that define the many conflicting goals. A robust goal formulation using the Design Capability Index (DCI) construct is employed in the framework to account for the design variable uncertainties. The use of iSOM for visualization of design spaces allows designers to overcome the limitation of conventional ternary plot-based visualization, where designers are limited to visualizing a maximum of 3 goals at a time. The framework presented supports designers in efficiently visualizing and exploring high-dimensional robust design spaces and identifying satisficing robust solutions, which was not possible previously.
Capturing Parkinson’s Disease Tremor and Vigor With a Single Disease Parameter
Authors: Haman Michael J. , Kelley Christopher R. 
Published: November 2023

Abstract
Parkinson’s disease (PD) is a progressive neurological disorder that significantly affects movement. It is caused by a loss of dopamine-producing cells in the basal ganglia, a group of brain structures that play a key role in motor control. Two of the most pronounced motor symptoms in PD are tremor and reduced movement vigor, known as bradykinesia. This research hypothesizes that a single physiological mechanism can produce both tremor and movement inhibition in PD through its influence on system-level controller parameters. This paper explores this hypothesis with a model that uses a single disease parameter to change the movement planning stage and closed-loop dynamics in a way that produces both motor symptoms. Model simulations evaluate the motion of the arm and the wrist during reaching and rest tasks as the disease parameter increases. The results confirm that a single parameter can produce parkinsonian-like tremor and vigor and also indicate that limb dynamics may play a key role in tremor expression.
Surrogate Modeling of Car Drag Coefficient With Depth and Normal Renderings
Authors: Song Binyang , Yuan Chenyang , Permenter Frank , Arechiga Nikos , Ahmed Faez 
Published: November 2023

Abstract
Generative AI models have made significant progress in automating the creation of 3D shapes, which has the potential to transform car design. In engineering design and optimization, evaluating engineering metrics is crucial. To make generative models performance-aware and enable them to create high-performing designs, surrogate modeling of these metrics is necessary. However, the currently used representations of three-dimensional (3D) shapes either require extensive computational resources to learn or suffer from significant information loss, which impairs their effectiveness in surrogate modeling. To address this issue, we propose a new two-dimensional (2D) representation of 3D shapes. We develop a surrogate drag model based on this representation to verify its effectiveness in predicting 3D car drag. We construct a diverse dataset of 9,070 high-quality 3D car meshes labeled by drag coefficients computed from computational fluid dynamics (CFD) simulations to train our model. Our experiments demonstrate that our model can accurately and efficiently evaluate drag coefficients with an R2 value above 0.84 for various car categories. Moreover, the proposed representation method can be generalized to many other product categories beyond cars. Our model is implemented using deep neural networks, making it compatible with recent AI image generation tools (such as Stable Diffusion) and a significant step towards the automatic generation of drag-optimized car designs. We have made the dataset and code publicly available at https://decode.mit.edu/projects/dragprediction/.
Novel treatments for novel side effects: a case report and review of baricitinib use in the treatment of chronic inflammatory demyelinating polyneuropathy caused by immune checkpoint inhibitor use
Authors: Haider Sana , Chua Wei , Balakrishnar Bavanthi , Della-Fiorentina Stephen , Roberts Tara Laurine , Keat Karuna 
Published: November 2023

Immune checkpoint inhibitors (ICIs) have transformed the landscape of solid cancer management. These drugs carry a risk of novel side effects, which have become known as immune-related adverse events (irAEs).Traditionally, irAEs have been managed empirically with corticosteroids. A subset of these may be steroid refractory and as more evidence emerges about their distinct pathogeneses, a more tailored approach is required. Here, we report the use of a Janus kinase (JAK) inhibitor, baricitinib, in a patient with chronic inflammatory demyelinating polyneuropathy secondary to ICI use. We also review the current literature with regards to the use of these inhibitors in the management of irAEs.Modulation of the JAK pathway warrants further investigation in the targeted management of irAEs.
The Dance Between Tumor Molecular Biology and Antitumor Immune Response
Authors: Margolin Kim A. 
Published: November 2023

Abstract
When the cyclin kinase 4/6 inhibitor abemaciclib was sequenced with PD-1 blockade in mostly immunologically “cold” murine models, enhanced immune-mediated antitumor effects—including increased lifespan, recruitment of CD8 cells to tumor, reduction of regulatory T-cell and immunosuppressive cytokines in tumor, increased tumor antigen presentation, and broadening of the T-cell receptor repertoire—were achieved in both cutaneous and brain metastases.
See related article by Nayyar et al., p. 420
Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J. 
Published: November 2023

Abstract
The histone lysine demethylases KDM4A-C are involved in physiologic processes including stem cell identity and self-renewal during development, DNA damage repair, and cell-cycle progression. KDM4A-C are overexpressed and associated with malignant cell behavior in multiple human cancers and are therefore potential therapeutic targets. Given the role of KDM4A-C in development and cancer, we aimed to test the potent, selective KDM4A-C inhibitor QC6352 on oncogenic cells of renal embryonic lineage. The anaplastic Wilms tumor cell line WiT49 and the tumor-forming human embryonic kidney cell line HEK293 demonstrated low nanomolar QC6352 sensitivity. The cytostatic response to QC6352 in WiT49 and HEK293 cells was marked by induction of DNA damage, a DNA repair–associated protein checkpoint response, S-phase cell-cycle arrest, profound reduction of ribosomal protein gene and rRNA transcription, and blockade of newly synthesized proteins. QC6352 caused reduction of KDM4A-C levels by a proteasome-associated mechanism. The cellular phenotype caused by QC6352 treatment of reduced migration, proliferation, tumor spheroid growth, DNA damage, and S-phase cell-cycle arrest was most closely mirrored by knockdown of KDM4A as determined by siRNA knockdown of KDM4A-C. QC6352 sensitivity correlated with high basal levels of ribosomal gene transcription in more than 900 human cancer cell lines. Targeting KDM4A may be of future therapeutic interest in oncogenic cells of embryonic renal lineage or cells with high basal expression of ribosomal protein genes.
Coronary Computed Tomography Angiography Versus Invasive Coronary Angiography in Stable Chest Pain: A Meta-Analysis of Randomized Controlled Trials
Authors: Machado Marina F. , Felix Nicole , Melo Pedro H.C. , Gauza Mateus M. , Calomeni Pedro , Generoso Giuliano , Khatri Sourabh , Altmayer Stephan , Blankstein Ron , Bittencourt Marcio Sommer , Cardoso Rhanderson 
Published: November 2023

BACKGROUND:
The efficacy of coronary computed tomography angiography (CCTA) versus invasive coronary angiography (ICA) among patients with stable chest pain has been studied in several trials with conflicting results.

METHODS:
We performed a systematic review and meta-analysis comparing CCTA first versus direct ICA among patients with stable chest pain, who were initially referred to ICA. PubMed, EMBASE, and Cochrane Central were searched for randomized controlled trials comparing the 2 strategies. Risk ratios (RRs) and mean differences with 95% CIs were computed for binary and continuous outcomes, respectively.

RESULTS:

Five randomized controlled trials with a total of 5727 patients were included, of whom 51.1% were referred to CCTA and 22.5% of patients had evidence of ischemia on a prior functional test. In the follow-up ranging from 1 to 3.5 years, 660 of the 2928 patients randomized to CCTA first underwent ICA (23%). Patients who underwent CCTA had lower rates of coronary revascularization (RR, 0.74 [95% CI, 0.66–0.84];
P
<0.001) and stroke (RR, 0.50 [95% CI, 0.26–0.98];
P
=0.043). Cardiovascular mortality (RR, 0.55 [95% CI, 0.24–1.23];
P
=0.146), major adverse cardiovascular events (RR, 0.84 [95% CI, 0.64–1.10];
P
=0.198), nonfatal myocardial infarction (RR, 1.09 [95% CI, 0.63–1.88];
P
=0.768), and cardiovascular hospitalizations (RR, 0.91 [95% CI, 0.59–1.39];
P
=0.669) did not differ significantly between groups.

CONCLUSIONS:
In patients with stable chest pain referred for ICA, CCTA avoided the need for ICA in 77% of patients otherwise referred for ICA. CCTA was associated with a reduction in the rates of coronary revascularization and stroke compared with direct ICA.

REGISTRATION:

URL:
https://www.crd.york.ac.uk/prospero/
; Unique identifier: CRD42023383143.
Ten recommendations for reducing the carbon footprint of research computing in human neuroimaging
Authors: Souter Nicholas E. , Lannelongue Loïc , Samuel Gabrielle , Racey Chris , Colling Lincoln J. , Bhagwat Nikhil , Selvan Raghavendra , Rae Charlotte L. 
Published: November 2023

Abstract
Given that scientific practices contribute to the climate crisis, scientists should reflect on the planetary impact of their work. Research computing can have a substantial carbon footprint in cases where researchers employ computationally expensive processes with large amounts of data. Analysis of human neuroimaging data, such as Magnetic Resonance Imaging brain scans, is one such case. Here, we consider ten ways in which those who conduct human neuroimaging research can reduce the carbon footprint of their research computing, by making adjustments to the ways in which studies are planned, executed, and analysed; as well as where and how data are stored.
An Atlantic Slave Trade Stretching from the Mediterranean to the Caribbean and Beyond
Authors: Wheat David , Lamikiz Xabier , Zaugg Roberto , Hatfield April Lee , Ribeiro da Silva Filipa , Roper L.H. , García-Montón Alejandro 
Published: November 2023

Abstract
The study of the trans-Atlantic slave trade is becoming increasingly sophisticated, diverse, and international. Challenging prevailing stereotypes about the dominance of northern European business interests, García Montón’s study shows the persistent vigor of Genoa’s merchant community in this examination of the asiento system that emerged in the mid-seventeenth century and continued into the mid-eighteenth century. Along the way, he also illuminates the slave trade’s connections to many other forms of trade, legitimate and illegitimate, on both sides of the Atlantic. Impressed with his research and approach, these six reviewers discuss its implications for a variety of international contexts, from Central Europe to Italy, Iberia, England, and the Caribbean, including the profitability of the asiento trade and the many different people who participated in and benefitted from it on both sides of the Atlantic. It emerges that the asiento was about much more than just the slave trade. Its profits and trading networks helped integrate the different imperial economies with footholds in the Caribbean. Drawing on the wealth of new scholarship from these different historiographies, they raise some questions about elements that García Montón did not pursue fully in the book. He responds with additional research to address some of those issues, while also calling for more research on the interconnected “asiento worlds” that are one of the most fascinating and unanticipated results of his research.
From Scarlet to Gold
Authors: Blum Lior 
Published: November 2023

Abstract
The history of the English Guinea Company (1618–1657) – the circumstances of its establishment in particular – has not drawn much attention from scholars during the last seventy years. Thus, this article focuses on the process leading to the foundation and chartering of the Guinea Company in November 1618, as well as on the company’s role in the history of English activity in West Africa. Using a re-discovered Chancery court case, it argues that the establishment of the company was the outcome of the convergence of two separate commercial trajectories: the development of the camwood trade in the 1610s and the gold-hunting trend that characterized the early stages of England’s overseas expansion process. This outcome, it is further argued, was a turning point in the history of English activity in West Africa, creating the platform that enabled the English to emerge as prominent players in the region in the 1670s.
Rural Youth Involvement in Oil Palm (Elaeis guineensis Jacq) Processing in Okitipupa Local Government Area, Ondo State, Nigeria
Authors: Chete Oluwatoyin Bukola 
Published: November 2023

Abstract
Youths have been found to lack interest in agricultural activities. This study investigated rural youth involvement in oil palm processing in Okitipupa local government area, Nigeria. Quantitative data were obtained from 120 rural youths through a multi-stage sampling procedure. Chi-square and correlation analysis were used to test the relationships between socio-economic characteristics, constraints on operations and the involvement of rural youth in oil palm processing. The mean age of respondents was 31 years; they were mostly single (65.0%) and literate (95.0%). Bad roads (x̅ = 2.98) and high cost of transportation (x̅ = 2.91) were the most severe constraints confronted by the respondents. Gender (χ2 = −32.85, p = 0.001) and years of education (χ2 = 96.51, p = 0.002) had a significant positive relationship with involvement in oil palm processing activities. Poor processing equipment (r = −0.38, p = 0.00) and bad roads (r = −0.40, p = 0.04) had a negative correlation with involvement in oil palm processing activities. Rehabilitation of road networks and access to innovative methods would improve involvement in oil palm processing activities.
Upbringing in a Context of Prolonged Collective Violence: Lived Experiences of Caregivers in Northern Uganda
Authors: De Nutte Leen 
Published: November 2023

Abstract
Given the far-reaching and long-term impact of collective violence and the post-conflict setting on the entire social ecology of children, this doctoral research explores how caregivers experience and negotiate the changes in children’s upbringing during and after collective violence, and how they receive support therein. Semi-structured interviews and focus group discussions were conducted with 59 caregivers and eight social workers living in post-conflict Kitgum District, northern Uganda, between 2014 and 2016. We gained important insights about the ways individuals, families and communities had coped with and adjusted their individual and communal worlds as a result of living under protracted war and armed conflict, spanning different generations and settings (i.e., forced displacement and encampment, captivity and post-war villages). We further illustrate how post-conflict return and reintegration following forced displacement, encampment and/or captivity can be regarded as complex and ongoing processes, which play out on different relational and structural levels and take place in a changed and changing social landscape.
‘Those Ridiculous Monks’
Authors: Song Nianshen 
Published: November 2023

Abstract
During the Qing Dynasty (1636–1911), Chosŏn Korean tributary envoys regularly sent to Beijing normally stopped for a few days en route in Mukden (Shenyang), the Qing’s secondary capital and the largest city in Manchuria. There they visited one of the local attractions, royal Tibetan Buddhist temples, particularly the Shishengsi, the largest monastery in the city. What drew the envoys to the royal temples? How did they interact with the Mongol lamas? What was their first impression of Tibetan Buddhism – a religion at once familiar and foreign to them? Using extensive records left by the Korean envoys (Yŏnhaengnok), this paper examines the under-studied historical encounter between Korean literati and Tibetan Buddhism. Although not always consistent, the understanding and misunderstanding that the Koreans had with the religion, I argue, reflects their rather complex political and cultural attitudes towards the Qing – a regime that, in the eyes of the Koreans, simultaneously represented China and non-China. The Manchu capital, Mukden, which was closely linked with both Beijing and the Inner Asian frontiers, provided a meeting ground for different ethnic groups, cultures and values in the late Imperial period. The episode demonstrates an initial interaction between East Asia and Inner Asia. Furthermore, by examining how information about Qing Inner Asian politics was filtered and (mis)understood by Koreans, the paper challenges the popular myth that more information naturally leads to comprehensive knowledge.
Reframing Special Protection and Immigration as an Emergency: Italy’s Not-So-Novel Approach
Authors: Talavera Lodos Silvia 
Published: November 2023

Abstract
The Italian government has decided to resort to a national state of emergency to manage recent migration flows. This approach, which has been used previously, aims at expanding the existing reception system. This is also accompanied by a set of measures, as outlined in Decreto Legge No. 20/2023, which adopt a more restrictive stance. This decree further restricts the possibility to grant special protection to asylum seekers and prosecutes more severely the participation in human trafficking operations. This paper analyses the latest developments in Italian law and outlines the legal issues they have raised.
Estimating the Impact of Hospice Care on Key Patient-Family Care Outcomes Using a Nationwide U.S. Probability Sample
Authors: Cagle John G. , Zhang Peiyuan , Clem Sarah 
Published: November 2023

Hospice is touted as an exemplary model for end-of-life care. However, there is little generalizable evidence estimating benefits of hospice at the national level. Using a national population-based probability sample of U.S. adults with weights applied (data collected Spring/Summer 2015), we conducted six logistic regression models to evaluate linkages between hospice involvement and end-of-life outcomes (pain, home death, presence of family, access to life-prolonging care, respect for spiritual/religious beliefs, financial burden) from N = 235 informal caregivers of decedents prior to death. Respondents were M = 55 years old (SD = 17), 55% female, 77% White, 91% non-Hispanic, and 71% had cared for a hospice recipient. In fully adjusted analyses, hospice users had better reported outcomes observed in two models: (a.) presence of family/friends at death (OR = 2.82, SE = .48, P < .05), and (b.) respect for spiritual/religious beliefs (OR = 9.52, SE = .73, P < .01). Hospice utilization was not statistically significant ( P > .05) in all other adjusted models. Although more research is needed, findings support claims that hospice remains a high quality option for end-of-life care in the U.S.