bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Effects of Berberine against Urological Cancers:
Biological Potentials Based on Cellular Mechanisms
Authors: Savoji Ali Bozorg , Kaheni Yasamin , Rezaei Pouria , Farkhondeh Tahereh , Pourhanifeh Mohammad Hossein , Samarghandian Saeed 
Published: November 2023

Background:
Urological cancers, encompassing prostate, kidney, and
bladder cancers, pose significant global health challenges. Current treatment
modalities, including chemotherapy, radiotherapy, and surgery, individually or in
combination, have limitations in efficacy and are associated with notable morbidity and
mortality.

Methods:
This review explores alternative therapeutic avenues, emphasizing the
exploration of natural compounds, with a specific focus on berberine. Berberine's
potential as a treatment for urological cancers is investigated through an extensive
examination of cellular and molecular mechanisms.

Results:
The comprehensive analysis reveals promising anticancer properties
associated with berberine, substantiated by a wealth of experimental studies. The
agent's impact on urological cancers is discussed, highlighting notable findings related
to its efficacy and safety profile.

Conclusions:
Given the high mortality rates and potential side effects associated with
current standard treatments for urological cancers, the exploration of alternative,
effective, and safer options is imperative. This review underscores berberine's
therapeutic potential, shedding light on its anticancer effects and encouraging further
research in the pursuit of enhanced treatment strategies.
Effect of elderly fitness exercise combined with Surya Namaskar Yoga on the youngest and middle old’ body mass index and physical fitness
Authors: Utami Desy Yunita , Sumaryanti Sumaryanti , Arovah Novita Intan , Graha Ali Satia , Suherman Wawan Sundawan , Putra Febriansyah Hendra Lukmana 
Published: November 2023

The purpose of this study was to analyze the effect of a combination of fitness exercise for the elderly and Suryanamaskar yoga on body mass index and physical fitness of youngest and middle old in Mojolaban District. This research is a quasi-experimental research with one group pretest-posttest design. The research population is the elderly in Mojolaban District. Sampling was done by purposive sampling from 42 elderly integrated healthcare center members. All samples followed the treatment with a frequency of 4x/week for 24 meetings, light intensity (DN elderly 96-112x/minute), 35 minutes. Then measured BMI with the formula Weight (kg)/Height (m2) and physical fitness was measured by the senior fitness test. Normality test using Shapiro Wilk followed by Wilcoxon Signed Rank test. The results of the study based on the Wilcoxon Signed Rank test for the youngest old, the pre-test value of 24.1538 ± SD 4.75014 decreased to 23.8381 ± SD 4.69895 in the post-test with a p-value of 0.01 in the BMI variable. The pre-test value of 10.05 ± SD 1.287 increased to 10.79 ± SD 1.554 in the post-test with a p-value of 0.001 on the physical fitness value variable. The results of the Wilcoxon Signed Rank test for the middle old obtained a p-value of 0.012 for the BMI variable and a p-value of 0.046 for the physical fitness value variable. It can be concluded that there is a decrease in the BMI of the youngest and middle old, as well as an increase in the physical fitness value of the youngest and middle old.
Analítica del uso o abuso en la desnaturalización de la acción de protección como garantía constitucional
Authors: Andrade Hidalgo Rolando 
Published: November 2023

La acción de protección se considera como un recurso para alcanzar la reparación de un derecho constitucional, el presente artículo se basó en la investigación analítica y reflexiva realizada en la ciudad de Loja durante el año 2019 tomando como muestra la Unidad Judicial Civil y Mercantil del cantón Loja, para señalar la eficiencia y eficacia de la acción constitucional que establezca los derechos infringidos de los particulares, así también aquellos demandados contra las instituciones públicas, para determinar la frecuencia con las que son interpuestas en la Unidad Judicial y de la totalidad presentada cuantas son admitidas o rechazadas, además verificar con la legislación ecuatoriana la procedencia del recurso, y el juzgador emita un veredicto motivado de su decisión para determinar la existencia de la vulneración de derechos constitucionales, puesto que si existe otra vía ordinaria o administrativa para reclamar dicha vulneración no será aceptada la acción de protección.
Eficacia del modelo pedagógico constructivista dentro ambientes virtuales de aprendizaje
Authors: Delgado Togra Danny Santiago , Aurora González Velásquez Aurora 
Published: November 2023

El presente trabajo de investigación aborda el análisis del modelo pedagógico constructivista y su relación con los entornos digitales de aprendizaje, por medio un análisis de dimensiones para determinar el impacto del modelo pedagógico constructivista en ambientes virtuales de aprendizaje. La metodología tuvo un enfoque mixto cuantitativo y cualitativo, su alcance es descriptivo – correlacional, la población objetivo de esta investigación fue de 113 estudiantes y 5 docentes de la Unidad Educativa “Ranulfo Aureliano Rodríguez” de Guayaquil-Ecuador. Para la recolección de datos se utilizaron dos instrumentos: “Modelo Pedagógico Constructivista” del autor Robalino (2016) para los docentes y “percepción de los estudiantes hacia la práctica docente e integración de TIC en el aula” del autor Yaguana (2019). Su aplicación fue mediante adaptación a formulario en línea, su posterior análisis correlacional fue en base al coeficiente de Spearman (rho). Los resultados obtenidos demostraron la correlación positiva moderada de 0,54 del modelo pedagógico constructivista sobre entornos virtuales durante el desarrollo de experiencias de aprendizaje, también fue evidenciable que ante una adecuada integración de contenidos y experticia de los docentes en el manejo de las herramientas de gestión de contenidos y del entorno virtual de aprendizaje mejora significativamente las posibilidades de éxito en lograr aprendizajes significativos y autonomía de los mismos.
Assessing the Performance of ChatGPT in Medical Biochemistry Using Clinical Case Vignettes: Observational Study
Authors: Surapaneni Krishna Mohan 
Published: November 2023

Background
ChatGPT has gained global attention recently owing to its high performance in generating a wide range of information and retrieving any kind of data instantaneously. ChatGPT has also been tested for the United States Medical Licensing Examination (USMLE) and has successfully cleared it. Thus, its usability in medical education is now one of the key discussions worldwide.

Objective
The objective of this study is to evaluate the performance of ChatGPT in medical biochemistry using clinical case vignettes.

Methods
The performance of ChatGPT was evaluated in medical biochemistry using 10 clinical case vignettes. Clinical case vignettes were randomly selected and inputted in ChatGPT along with the response options. We tested the responses for each clinical case twice. The answers generated by ChatGPT were saved and checked using our reference material.

Results
ChatGPT generated correct answers for 4 questions on the first attempt. For the other cases, there were differences in responses generated by ChatGPT in the first and second attempts. In the second attempt, ChatGPT provided correct answers for 6 questions and incorrect answers for 4 questions out of the 10 cases that were used. But, to our surprise, for case 3, different answers were obtained with multiple attempts. We believe this to have happened owing to the complexity of the case, which involved addressing various critical medical aspects related to amino acid metabolism in a balanced approach.

Conclusions
According to the findings of our study, ChatGPT may not be considered an accurate information provider for application in medical education to improve learning and assessment. However, our study was limited by a small sample size (10 clinical case vignettes) and the use of the publicly available version of ChatGPT (version 3.5). Although artificial intelligence (AI) has the capability to transform medical education, we emphasize the validation of such data produced by such AI systems for correctness and dependability before it could be implemented in practice.
The burden of tuberculosis disease in women, Colombia 2010-2018
Authors: Plata-Casas Laura , Gutiérrez-Lesmes Oscar , Cala-Vitery Favio 
Published: November 2023

Objective: to estimate disability-adjusted life years in women attributable to tuberculosis in Colombia 2010-2018. Methods: A retrospective descriptive study was conducted. The following variables were studied: year of occurrence, age groups and origin. This study included 41,354 women who consulted in the hospital network and 2530 cases of mortality in women, registered in the country’s vital statistics system. Using the abbrevia¬ted methodology proposed by the World Health Organization for measuring the burden of disease BD, years of life lost, years of life with disability and years of healthy life lost by women at the subnational level were estimated. Results: The Disability-Adjusted Life Years rate for the study period was 427.2 (95% II 353-492.3) per 100,000 women. Women of reproductive age (10 to 49 years old) account for 57.9 per cent of these. Departments such as Amazonas 1,426 (725.4-2,541.4) and Guajira 1,001.1 (693.3-1,260) had the highest rates (per 100,000 inhabitants). Twelve territorial entities have an increasing burden of disease. Conclusions: The rate of disability-adjusted life years due to tuberculosis in women for nine years was high and presents subnational differences perhaps due to large social or economic gaps or deficits in institutional or programmatic capacities.
DUKUNGAN SOSIAL MASYARAKAT TERHADAP ANAK PENDERITA KANKER DI RUMAH SINGGAH CHILDREN CANCER CARE COMMUNITY (C-FOUR)
Authors: Ramli Isni Radifa , Sabirin Sabirin , Sakdiah Sakdiah 
Published: November 2023

Abstract: Cancer is a deadly disease in the world, cancer can affect anyone, of any age and gender. Every cancer patient needs strength such as social support from family and the environment around them. This research focuses on the social support of the surrounding community given to children with cancer at the C-Four shelter, the encouragement given by the surrounding community will have a major effect on the recovery of children with cancer. The purpose of this study is to determine the social support of the surrounding community for children with cancer. The method used is a qualitative research method with descriptive methods, interviews, observation and research documentation. The informants in this study were the community of Bandar Baru village, the village secretary of Bandar Baru village, the founder or chairman of the C-Four foundation and parents of cancer patients at the C-Four shelter. The results showed that the community provides very high social support to parents and children with cancer at the halfway house, but there are also a few people who still have obstacles in providing social support.Keywords: Social Support; Child; Cancer Patients.Abstrak: Kanker merupakan suatu penyakit yang mematikan di dunia, kanker dapat menyerang siapa saja, dari berbagai usia dan jenis kelamin. Setiap penderita kanker membutuhkan kekuatan seperti dukungan sosial dari keluarga maupun lingkungan sekitar mereka. Penelitian ini berfokus pada dukungan sosial masyarakat sekitar yang diberikan kepada anak penderita kanker di rumah singgah C-Four, dorongan yang diberikan oleh masyarakat sekitar akan berpengaruh besar terhadap kesembuhan anak penderita kanker. Tujuan dari penelitian ini adalah untuk mengetahui dukungan sosial masyarakat sekitar terhadap anak penderita kanker. Metode yang digunakan adalah metode penelitian kualitatif dengan metode deskriptif, wawancara, observasi dan dokumentasi penelitian. Informan pada penelitian ini adalah masyarakat Gampong Bandar Baru, Sekdes Gampong Bandar Baru, pendiri atau ketua yayasan C-Four dan orang tua penderita kanker di rumah singgah C-Four. Hasil penelitian menunjukkan bahwa masyarakat memberikan dukungan sosial yang sangat tinggi kepada orang tua dan anak penderita kanker di rumah singgah, namun juga ada sedikit banyaknya masyarakat yang masih memiliki hambatan dalam memberikan dukungan sosial.Kata Kunci: Dukungan Sosial; Anak; Penderita Kanker.
PENGELOLAAN LINGKUNGAN BERBASIS PARTISIPASI MASYARAKAT SECARA BERKELANJUTAN DI KAMPUNG BAHARI TAMBAK LOROK KOTA SEMARANG
Authors: Adissa Kurnia Nur , Hamid Nur , Riyadi Agus , Kasmuri Kasmuri , Mudhofi Mudhofi 
Published: November 2023

Abstract: Tambak Lorok is a “kampung nelayan” that still seems slum in some places. Then, the government embraced the community to participate in preserving their environment by changing it to Kampung Bahari in 2014. This research aims to determine the forms of participation and sustainability of holding Kampung Bahari in Tambak Lorok, Semarang City. The method used in this research is a qualitative method with a case study approach. Data collection was carried out through interviews and direct field observations. The research results show that the Tambak Lorok Community has realized forms of participation, which include energy participation, thought participation, property participation, skills and skills participation, and social participation. The sustainability of Kampung Bahari and several programs related to environmental preservation are still going well. The Tambak Lorok community continues to improve the quality of their area by carrying out many ongoing programs.Keywords: Society Participation; Environmental Consvertation; Tambak Lorok.Abstrak: Tambak Lorok merupakan “kampung nelayan” yang hingga saat ini masih terkesan kumuh di beberapa titik tempatnya. Kemudian pemerintah merangkul masyarakat untuk berpartisipasi dalam melestarikan lingkungannya sendiri, dengan merubahnya menjadi Kampung Bahari pada tahun 2014. Tujuan dari penelitian ini adalah untuk mengetahui bentuk-bentuk partisipasi serta keberlanjutan pelestarian kampung Bahari di Tambak Lorok Kota Semarang. Metode yang digunakan dalam penelitian ini adalah metode kualitatif, dengan pendekatan studi kasus. Pengambilan data dilakukan melalui wawancara dan observasi ke lapangan secara langsung. Hasil penelitian menunjukkan bahwa masyarakat Tambak Lorok telah merealisasikan bentuk-bentuk partisipasi yang meliputi partisipasi tenaga, partisipasi buah pikiran, partisipasi harta benda, partisipasi kemahiran dan keterampilan, serta partisipasi sosial. Keberlanjutan Kampung Bahari serta beberapa program terkait pelestarian lingkungan juga hingga saat ini masih berlangsung dengan baik. Masyarakat Tambak Lorok terus meningkatkan kualitas wilayah mereka dengan menjalankan banyaknya program yang terus berlanjut.Kata Kunci: Partisipasi Masyarakat; Pelestarian Lingkungan; Tambak Lorok.
REFLECTION OF SUFI POCUT DI BEUTONG IN ACEH’S MANUSCRIPT
Authors: Abdullah Munawiah , Husna Nurul , Akbar Arif , Zaenab Cut 
Published: November 2023

Abstrak: Tulisan ini bermaksud untuk mendeskripsikan sosok perempuan sufi di Aceh yang dikenal dengan sebutan Pocut di Butong yang terdapat dalam naskah tersebut. Sejarah panjang tasawuf di Aceh memberikan peranan yang sangat penting bagi masyarakat Aceh. Aceh yang juga dikenal dengan nama Serambi Mekkah, pada saat itu diterapkan syariat Islam. Keberadaan para sufi atau pembawa tasawuf begitu esensialnya agar ajaran tersebut terus berkembang. Sufi di Aceh terkenal di kalangan laki-laki karena sikap mereka yang tidak peduli terhadap perempuan. Di kalangan sufi perempuan, keberadaannya sangat minim dan tidak tertulis dalam sejarah apapun. Yang paling sering disebutkan adalah Rabiah al-Adawiyah, namun sufi perempuan masih perlu lebih banyak dipublikasikan, dan lain halnya jika tokohnya laki-laki. Penelitian ini merupakan tinjauan naskah ‘Munajat Perempuan Sufi Aceh Pocut di Beutong’ mengenai eksistensi dan peran seorang sufi perempuan berinisial Pocut di Beutong. Hasil penelitian menunjukkan bahwa puisi-puisi dalam buku ‘Munajat Wanita Sufi Aceh’ menjelaskan bahwa keberadaan dan peranan Pocut di Beutong sangat berarti pada masa itu. Hal ini terlihat dari sejarah yang diceritakan dalam buku tersebut mengenai bagaimana Pocut di Beutong turut membantu mempertahankan tanah Aceh dengan berbagai cara, seperti berdoa, mengajar, mengembangkan amalan, dan berupaya mendekatkan diri kepada Allah. Hal ini sama pentingnya dengan Cut Nyak Dien dan pahlawan wanita lainnya yang akan berperang.Kata Kunci: Naskah; Wanita Sufi; Aceh.Abstract: This paper intends to describe the Sufis woman in Aceh, known as Pocut di Butong contained in the manuscript. The long history of Sufism in Aceh provides a crucial role for the people of Acehnese. Aceh, also known as Serambi Mecca, at that time of Islamic law was implemented. The existence of Sufi or carriers of Sufism is so essential that these teachings continue to develop. Sufi in Aceh have been popular with men for their disregard for women. Among female Sufis, their existence is minimal and not written in any history. The most often mentioned is Rabiah al-Adawiyah, but more female Sufis still need to be published, and it is different if the character is male. This study is a manuscript review of ‘Munajat Perempuan Sufi Aceh Pocut di Beutong’ regarding the existence and role of a female Sufis with the initial Pocut di Beutong. The study results show that the poems in the book ‘Munajat Wanita Sufi Aceh’ explain that the existence and role of Pocut di Beutong was very significant at that time. This can be seen from the history recounted in the book regarding how Pocut di Beutong also helped defend the land of Aceh in different ways, such as praying, teaching, developing practice, and attempting to get closer to Allah. This is just as important as Cut Nyak Dien and other female heroes going to war.Keywords: Manuscript; Sufis Woman; Aceh.
Climate Smart Bread Wheat (Triticum aestivum L.) Variety Development for Optimum Moisture Areas of Ethiopia
Authors: Alemu Gadisa , Dabi Alemu , Sime Berhanu , Geleta Negash , Delesa Abebe , Zegaye Habtemariam , Duga Ruth , Kasahun Cherinet , Negash Tamirat , Solomon Tafesse , Zewdu Demeke , Asefa Bayisa , Tadesse Zerihun , Abeyo Bekele , Badebo Ayele , Bayisa Tilahun 
Published: November 2023

A study was undertaken during the 2017–18 to 2018–19 cropping seasons at at eleven locations and/or seventeen environments in optimum moisture areas of Ethiopian to identify stable genotypes with high grain yield and release as a variety for optimum-moisture environments. Alpha-lattice design with three replications was used. The combined ANOVA revealed very highly significant differences (p≤0.001) among genotypes, environments, and GEI for yield and its components. The environment sum of squares contributed more than the genotype and GEI sum of squares for the total variance of all traits. When we consider the overall mean for grain yield, genotype ETBW8751 (5.12 t ha-1) the highest value followed by ETBW9554 (5.10 t ha-1) whereas the lowest grain yield was obtained from the genotype ETBW8804 (3.67 t ha-1). GGE and AMMI analysis explained almost similar amounts of variation; however, AMMI still show a slightly greater proportion than GGE during our study. According to AMMI and GGE analysis genotype 21 (ETBW9553) was more stable as well as high yielding followed by 22 (ETBW9554) and 2 (ETBW8751. Conversely, 15 (ETBW9547) was unstable, but high yielding. Hidasse had low yields but was unstable. ETBW9554 was validated on farmers’ fields and recommended for registration as a commercial variety and finally released in 2020 with its designated local name “Boru” for commercial production for mid to highland agro-ecologies in Ethiopia.
Understanding a Changing Approach to Gender in Studies on Roman Baths
Authors: Maréchal Sadi 
Published: November 2023

Cet article examine comment des questions de recherche concernant le genre ont été incluses dans des études sur les bains grecs et romains. Et en outre, comment l’implication de ces questions a-t-elle influencé la perception des bains antiques ? Les premières études « antiquaires » prêtaient peu d’attention aux baigneurs, hommes ou femmes, se focalisant d’abord sur l’architecture, la technologie et la décoration de ces édifices. C’est seulement à partir de la seconde moitié du 20e siècle, poussés par des changements épistémologiques dans le domaine des sciences humaines, que les spécialistes ont commencé à inclure les femmes dans leurs discours. Trois questions ont souvent été réitérées depuis : les femmes allaient-elles aux bains publics ? Les femmes se baignaient-elles avec les hommes ? Et que portaient-elles dans les bains ? Dans la dernière décennie du siècle dernier et la première du nouveau, les études sur les bains antiques commencent progressivement à inclure des questions sur d’autres groupes de genre. Cependant, ces nouveaux discours ne sont que lentement intégrés dans les reconstructions virtuelles, qui semblent toujours très influencées par les traditionnels dessins architecturaux.
Masing Manifolds: Reconciling the Masing Conditions with Real Hysteresis in Jointed Structures
Authors: Brake M. R. W. , Porter J. H. , Karpov M. M. 
Published: November 2023

The Masing conditions establish a criterion to relate the loading curve of a hysteretic system (e.g., systems with friction or plasticity) to its complete hysteresis loop. For the field of joint mechanics, where hysteretic models are often used to describe the dissipative, tangential behavior within an interface, the Masing conditions allow for significant computational savings when the normal load is constant. In practice, though, jointed systems experience time varying normal forces that modify the tangential behavior of the system. Consequently, the hysteretic behavior of jointed structures do not adhere to the Masing conditions. In this work, this discrepancy between the Masing conditions and behavior exhibited by jointed structures is explored, and it is hypothesized that if the Masing conditions accounted for variations in normal force, then they would more accurately represent jointed structures. A new set of conditions is introduced to the original set of Masing conditions, yielding a « Masing manifold » that spans the tangential displacement-tangential force-normal force space. Both a simple harmonic oscillator and a built-up structure are investigated for the case of elastic dry friction, and the results show that the hysteresis of both of these systems conforms to the three dimensional Masing manifold exactly, provided that a set of constraints are satisfied, even though the hysteresis does not conform with the original Masing conditions.