bluuebunny/crossref_metadata_2025_split huggingface dataset:
A balancing act between accuracy and timeliness: Evidence from analyst forecasts in China
Authors: Han Lining , Qiu Bin , Yang Xixi , Zhao Yiwei 
Published: February 2024

AbstractThis paper investigates the impact of teamwork on analysts' ability to balance accuracy and timeliness. Surprisingly, team analysts demonstrate a lower ability compared to individual analysts. This trade‐off ability is even worse in diverse teams. Further, we find that Confucianism negatively affects this ability. However, this ability significantly improves when star analysts serve on the analyst team, or when analyst team members come from the province where the covered firm is headquartered, or when analyst team members graduate from the same college. Overall, these findings suggest that it is crucial to consider the two performance dimensions simultaneously.
Do CEOs Who Are Raising Daughters Reduce Company Risk‐taking?*
Authors: Feng Mingming , Wang Xia , Xu Xiaodong , Zhou Mengjiao 
Published: February 2024

AbstractFamily structure and characteristics are important factors that affect both economic development and CEOs' decision‐making. Corporate risk‐taking reflects the overall risk choices and preferences of decision‐makers in relation to various decisions. Using data for Chinese non‐state‐owned enterprises between the years 2000 and 2019, we examine the association between CEO offspring gender and corporate risk‐taking. We find that CEOs who have daughters are associated with a lower level of corporate risk‐taking than CEOs who have sons only. Raising daughters significantly stimulates cautious attitudes and behaviors in CEOs and reduces firm overinvestment, thereby lowering the level of corporate risk‐taking. Moreover, raising daughters has a more significant inhibitory effect on corporate risk‐taking for female CEOs and CEOs who were born in regions with a strong patriarchal culture. Our findings also show that CEOs with daughters can help companies effectively avoid financial crises. Focusing on both parenting behavior and corporate financial behavior, we suggest that the parent–child relationship extends far beyond the scope of the family, providing a broader perspective for understanding corporate decision‐making and financial behavior.
Diabetic retinopathy among the elderly with type 2 diabetes: A Nationwide longitudinal registry study
Authors: Sharif Ali , Smith Daniel R. , Hellgren Karl‐Johan , Jendle Johan 
Published: February 2024

AbstractPurposeTo investigate the prevalence, incidence and risk factors of DR in elderly people living with type 2 diabetes.MethodsIndividuals >80 years, in the Swedish National Diabetes Register (NDR) between 2008 and 2017, were included. Prevalence and incidence were calculated and stratified by age. Estimates were assessed by longitudinal binary logistic regression models.ResultsOne hundred forty‐one thousand, one hundred fifty‐eight individuals with type 2 diabetes were included, median age 83 years, 53.3% females and with a median HbA1c 52 mmol/mol. The DR prevalence was stable at 336.2 cases/1000 patients in 2008 (95% CI, 330.2–342.3), with no significant changes during the 10‐year period. Crude DR incidence rate: 88.5 cases/1000 patient years (95% CI, 87.6–89.4). The incidence rate was lower at higher ages. The effect of age on incident DR varied by sex, with females having an increasingly higher risk than males from 83 years of age, OR 1.25 (1.11–1.42) at age 90 years. The risk of incident DR with longer diabetes duration increased more rapidly at worse glycaemic control.ConclusionThe growing population of elderly with type 2 diabetes shows a stable proportion of DR and proposes an increased need for DR screening and eye care. Established risk factors for DR, such as diabetes duration and level of glycaemic control, are also important in the elderly; however, age and sex should be considered.
Antecedents of electric vehicle purchasing behaviors: Evidence from Türkiye
Authors: Ramadani Veland , Armutcu Barış , Reshidi Nail , Tan Ahmet , İnce Ercan 
Published: February 2024

AbstractThe present study aims to determine the key antecedents that affect consumers' electric vehicle (EV) purchasing behavior. In this context, the study expanded the existing framework of TPB (attitude, subjective norms, perceived behavioral control) by incorporating four new variables (product attributes, cognitive status, monetary incentive policies, and nonmonetary incentive policies). At this point, the study is of great importance in terms of understanding consumers' perspectives on EV purchasing behavior and to help policymakers, businesses, and marketers support sustainable production and consumption by creating effective strategies. In addition, this study conducted in Türkiye, which shares similar consumption behaviors with Middle Eastern, Asian, and European societies, provides valuable insights for a rapid transition to the adoption of EVs. In the study, data were collected from 390 respondents with the survey method and the collected data were analyzed using Smart PLS 4.0 and SPSS 26 statistical software. The findings showed that only attitude together with cognitive status, product attributes, and monetary incentives policy contribute to EV purchasing behavior. In light of these findings, it can be argued that there is a need to increase efforts to develop more positive consumer attitudes toward EVs, to enhance their cognitive status, and to promote product attributes to encourage the widespread adoption of EVs. At the same time, monetary incentives policies are an important element in the adoption of EVs and therefore policymakers need to make great efforts.
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
Authors: Scharf Magdalena M. , Humphrys Laura J. , Berndt Sandra , Di Pizio Antonella , Lehmann Juliane , Liebscher Ines , Nicoli Alessandro , Niv Masha Y. , Peri Lior , Schihada Hannes , Schulte Gunnar 
Published: February 2024

AbstractA large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further. Open questions on these GPCRs span diverse topics such as deorphanisation, the development of tool compounds and tools for studying these GPCRs, as well as understanding basic signalling mechanisms. This review gives an overview of the current state of knowledge for each of the diverse subfamilies of understudied receptors regarding their physiological relevance, molecular mechanisms, endogenous ligands and pharmacological tools. Furthermore, it identifies some of the largest knowledge gaps that should be addressed in the foreseeable future and lists some general strategies that might be helpful in this process.
Giant cell collagenomas associated with Cowden syndrome: A case report
Authors: Salusti‐Simpson Michela , Madrid Michael , Cook Deborah 
Published: February 2024

AbstractStoriform collagenoma, also known as sclerotic fibroma, is a relatively rare benign cutaneous tumor consisting of a proliferation of fibroblasts that shows increased production of type I collagen. It may appear as a solitary, sporadic lesion, or, especially when multiple, associated with Cowden syndrome. Giant cell collagenoma has a histopathologic appearance similar to that of storiform collagenoma with the addition of floret‐type giant cells. Herein, we report the finding of multiple giant cell collagenomas arising in an individual with Cowden syndrome. In a review of the published literature, this histopathologic variant appears to be rarely observed in association with Cowden syndrome.
Metabolomic changes in adults with status epilepticus: A human case–control study
Authors: Hanin Aurélie , Chollet Céline , Demeret Sophie , Di Meglio Lucas , Castelli Florence , Navarro Vincent 
Published: February 2024

AbstractObjectiveStatus epilepticus (SE) is a life‐threatening prolonged epileptic seizure that affects ~40 per 100 000 people yearly worldwide. The persistence of seizures may lead to excitotoxic processes, neuronal loss, and neuroinflammation, resulting in long‐term neurocognitive and functional disabilities. A better understanding of the pathophysiological mechanisms underlying SE consequences is crucial for improving SE management and preventing secondary neuronal injury.MethodsWe conducted a comprehensive untargeted metabolomic analysis, using liquid chromatography coupled with high‐resolution mass spectrometry (LC‐HRMS), on plasma and cerebrospinal fluid (CSF) samples from 78 adult patients with SE and 107 control patients without SE, including 29 with CSF for both groups. The metabolomic fingerprints were compared between patients with SE and controls. Metabolites with differences in relative abundances that could not be attributed to treatment or nutrition provided in the intensive care unit were isolated. Enrichment analysis was performed on these metabolites to identify the most affected pathways.ResultsWe identified 76 metabolites in the plasma and 37 in the CSF that exhibited differential expression in patients with SE compared to controls. The enrichment analysis revealed that metabolic dysregulations in patients with SE affected primarily amino acid metabolism (including glutamate, alanine, tryptophan, glycine, and serine metabolism), pyrimidine metabolism, and lipid homeostasis. Specifically, patients with SE had elevated levels of pyruvate, quinolinic acid, and keto butyric acid levels, along with lower levels of arginine, N‐acetylaspartylglutamate (NAAG), tryptophan, uracil, and uridine. The tryptophan kynurenine pathway was identified as the most significantly altered in SE, resulting in the overproduction of quinolinic acid, an N‐methyl‐d‐aspartate (NMDA) receptor agonist with pro‐inflammatory properties.SignificanceThis study has identified several pathways that may play pivotal roles in SE consequences, such as the tryptophan kynurenine pathway. These findings offer novel perspectives for the development of neuroprotective therapeutics.
Development of a short form of the Japanese version of the Caregiver Reaction Assessment (CRA‐J‐10) among informal caregivers of older adults
Authors: Noguchi Taiji , Nakagawa Takeshi , Jin Xueying , Komatsu Ayane , Togashi Shintaro , Miyashita Mitsunori , Saito Tami 
Published: February 2024

AimTo support informal caregivers, a simple assessment tool capturing the multidimensional nature of caregiving experiences, including negative and positive aspects, is required. We developed a short form of the Japanese version of the Caregiver Reaction Assessment (CRA‐J), a multidimensional assessment scale for caregiver experiences.MethodsThe internet survey involved 934 Japanese informal caregivers aged 20–79 years (mean age = 58.8 years; 50.2% women) who completed questionnaires, including the CRA‐J 18 items (CRA‐J‐18), consisting of five domains, such as impacts on schedule and finances and positive experiences of caregiving. A 10‐item short version of the CRA‐J (CRA‐J‐10; 0–50 points), which was prepared by selecting the two items with the highest factor loadings from each domain, was tested for model fit by confirmatory factor analysis (CFA) and was analyzed for correlations with the CRA‐J‐18, Zarit Burden Interview (ZBI), Positive Aspects of Caregiving Scale (PACS), Patient Health Questionnaire‐9 (PHQ‐9), and WHO‐Five Well‐Being Index (WHO‐5). The area under the curve (AUC) in the receiver operating characteristic was evaluated as discriminability for depressive symptoms (PHQ‐9 ≥ 10 points).ResultsThe CFA indicated a good model fit in the CRA‐J‐10. The CRA‐J‐10 correlated well with the CRA‐J‐18 and other variables (CRA‐J‐18, r = 0.970; ZBI, r = 0.747; PACS, r = −0.467; PHQ‐9, r = 0.582; WHO‐5, r = −0.588) and showed good discriminant performance for the presence of depressive symptoms (AUC = 0.793, 95% confidence interval = 0.762–0.823).ConclusionsThe CRA‐J‐10 allows a simple assessment of caregiver experiences, helping support informal caregivers. Geriatr Gerontol Int 2024; 24: 290–296.
C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L‐BO4 in a mouse model
Authors: Uekita Takamasa , Yagi Reiko , Ichimura Tohru , Sakai Ryuichi 
Published: February 2024

AbstractLung cancer frequently metastasizes to the bones. An in vivo model is urgently required to identify potential therapeutic targets for the prevention and treatment of lung cancer with bone metastasis. We established a lung adenocarcinoma cell subline (H322L‐BO4) that specifically showed metastasis to the leg bones and adrenal glands. This was achieved by repeated isolation of metastatic cells from the leg bones of mice. The cells were intracardially injected into nude mice. Survival was prolonged for mice that received H322L‐BO4 cells versus original cells (H322L). H322L‐BO4 cells did not exhibit obvious changes in general in vitro properties associated with the metastatic potential (e.g., cell growth, migration, and invasion) compared with H322L cells. However, the phosphorylation of chromosome 9 open reading frame 10/oxidative stress‐associated Src activator (C9orf10/Ossa) was increased in H322L‐BO4 cells. This result confirmed the increased anchorage independence through C9orf10/Ossa‐mediated activation of Src family tyrosine kinase. Reduction of C9orf10/Ossa by shRNA reduced cells' metastasis to the leg bone and prolonged survival in mice. These findings indicate that H322L‐BO4 cells can be used to evaluate the effect of candidate therapeutic targets against bone metastatic lung cancer cells. Moreover, C9orf10/Ossa may be a useful target for treatment of lung cancer with bone metastasis.
Next‐generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin
Authors: Toledano‐Osorio Manuel , Osorio Raquel , Bueno Jaime , Vallecillo Cristina , Vallecillo‐Rivas Marta , Sanz Mariano 
Published: February 2024

AbstractBackground‘Periodontitis’ refers to periodontal destruction of connective tissue attachment and bone, in response to microorganisms forming subgingival biofilms on the root surface, while ‘apical periodontitis’ refers to periapical inflammatory processes occurring in response to microorganisms within the root canal system. The treatment of both diseases is based on the elimination of the bacterial challenge, though its predictability depends on the ability of disrupting these biofilms, what may need adjunctive antibacterial strategies, such as the next‐generation antibacterial strategies (NGAS). From all the newly developed NGAS, the use of polymeric nanotechnology may pose a potential effective approach. Although some of these strategies have only been tested in vitro and in preclinical in vivo models, their use holds a great potential, and therefore, it is relevant to understand their mechanism of action and evaluate their scientific evidence of efficacy.ObjectivesTo explore NGAS based on polymeric nanotechnology used for the potential treatment of periodontitis and apical periodontitis.MethodA systemic search of scientific publications of adjunctive antimicrobial strategies using nanopolymers to treat periodontal and periapical diseases was conducted using The National Library of Medicine (MEDLINE by PubMed), The Cochrane Oral Health Group Trials Register, EMBASE and Web of Science.ResultsDifferent polymeric nanoparticles, nanofibres and nanostructured hydrogels combined with antimicrobial substances have been identified in the periodontal literature, being the most commonly used nanopolymers of polycaprolactone, poly(lactic‐co‐glycolic acid) and chitosan. As antimicrobials, the most frequently used have been antibiotics, though other antimicrobial substances, such as metallic ions, peptides and naturally derived products, have also been added to the nanopolymers.ConclusionPolymeric nanomaterials containing antimicrobial compounds may be considered as a potential NGAS. Its relative efficacy, however, is not well understood since most of the existing evidence is derived from in vitro or preclinical in vivo studies.
Meta‐analysis on the impact of immune senescence: Unravelling the interplay in cutaneous wound healing and lung cancer progression
Authors: Dong Mengqian , Jin Ying , Lin Xiaoyang , Wang Shuangshuang , Shen Peihong 
Published: February 2024

AbstractThe primary objective of this meta‐analysis was to provide the comprehensive understanding of the intricate correlation that existed between immune senescence and its effects on the advancement of lung cancer as well as recovery of cutaneous wounds. By conducting this systematic review of six rigorous studies utilizing databases such as PubMed and Web of Science, this research examined the multitude of facets pertaining to immune aging and consequences it bear on the health outcomes. The incorporated studies encompassed wide range of geographical and methodological viewpoints, with the specific emphasis on non‐small‐cell lung cancer and diverse scenarios related to wound recovery. This analysis synthesized discoveries regarding therapeutic responses, cellular and molecular mechanisms and impact of lifestyle factors on immune senescence. The findings suggested that immune senescence has substantial impact on the effectiveness of treatments for lung cancer and cutaneous wounds healing process; therefore, targeted therapies and holistic approaches may be able to mitigate these effects. By following the revised PRISMA guidelines, this meta‐analysis guarantee thorough and ethically sound methodology for amalgamating pre‐existing literature. The study concluded by emphasizing the critical nature of comprehending immune senescence in the context of clinical practice and proposed avenues for further investigation to enhance health results among the elderly.
Estimation of genetic parameters for reproductive indices in sheep
Authors: Senes Beatriz Bastos , da Cruz Valdecy Aparecida Rocha , Azevedo Hymerson Costa , Costa Raphael Bermal , de Camargo Gregório Miguel Ferreira 
Published: February 2024

AbstractThis study aimed to estimate two reproductive efficiency indices in sheep based on the ratio between litter weight (at birth and weaning) and dam weight, as well as their genetic parameters. Phenotypic and pedigree data comprising the period from 1990 to 2018 were obtained from the Santa Inês sheep database of Embrapa Tabuleiros Costeiros. For estimation of the genetic parameters of the indices, a repeatability model was applied in single‐ and two‐trait analyses by a Bayesian approach. The mean reproductive efficiency index was 0.069 ± 0.0163 and 0.43 ± 0.0955 at birth and weaning, respectively. These values indicate that, on average, ewes give birth to 69 g of lamb per kg body weight and wean 430 g of lamb per kg body weight. Described here for the first time, the heritability estimate obtained in single‐ and two‐trait analyses was 0.24 for the index based on birth weights and ranged from 0.13 to 0.15 for the index based on weaning weights. The estimates indicate the possibility of genetic gain by selection and are similar to those reported for reproductive traits in sheep, representing an option for selection criterion. The genetic correlation between indices was positive and moderate (0.26). The repeatability estimates were high (0.49 for the birth weight index and 0.71 for the weaning weight index). These values indicate good prediction of future performance with few observations. The weaning weight index might be a good culling criterion of females.
Climate‐related variation of metabolic rate across the distribution of a broadly tolerant invasive forest pest
Authors: Powers Sean D. , Thompson Lily M. , Parry Dylan , Grayson Kristine L. , Martinez Eloy , Agosta Salvatore J. 
Published: February 2024

AbstractAimMetabolic rate is a widely studied physiological species trait related to energetics, climate, and geographical distributions. Hypotheses have been proposed to explain variation in metabolic rate, but evidence has been mixed due to the limited sampling scope of intraspecific studies. Successful biological invasions offer a unique opportunity to examine the development of intraspecific physiological variation and how it relates to climate, invasive spread and species range limits. The aim of this study was to determine if metabolic rate variation across the spongy moth invasive range was consistent with a pattern of adaptation to local climate.LocationNortheastern United States of America.TaxonLymantria dispar dispar L. (Lepidoptera: Erebidae).MethodsLarvae were sourced from 14 populations across the invasion front and interior of the current L. d. dispar invasive range and were reared at a constant temperature. Routine metabolic rates (RMR) of larvae were assayed at three ecologically relevant temperatures. These data were analysed to determine if there were differences in RMR and temperature sensitivity of RMR among populations. Population‐level variation in RMR was then analysed as a function of local climate and geographical position to test for patterns consistent with local adaptation.ResultsLarval RMR showed significant variation among populations across all assay temperatures, but there was no difference in temperature sensitivity (i.e. slope). This variation followed a positive latitudinal cline with RMR increasing from the southern range to the north. This cline also showed a significant relationship with local climate variables.Main ConclusionsLarval metabolic rate variation was consistent with a pattern of adaptation by L. d. dispar to divergent climates across its invasive range. These results indicated that thermal adaptation of whole‐organism physiology may play a key role in promoting species spread and expansion for biological invasions like L. d. dispar.
The Effect of CenteringPregnancy Group Antenatal Care on Maternal, Birth, and Neonatal Outcomes Among Low‐Risk Women in the Netherlands: A Stepped‐Wedge Cluster Randomized Trial
Authors: Wagijo Mary‐ann , Crone Mathilde , Bruinsma‐van Zwicht Birgit , van Lith Jan , Billings Deborah , Rijnders Marlies 
Published: February 2024

IntroductionThis study was carried out to assess the effects of participating in CenteringPregnancy (CP) on maternal, birth, and neonatal outcomes among low‐risk pregnant women in the Netherlands.MethodsA total of 2124 pregnant women in primary care were included in the study. Data were derived from the Dutch national database, Perined, complemented with data from questionnaires completed by pregnant women. A stepwise‐wedge design was employed; multilevel intention‐to‐treat analyses and propensity score matching were the main analytic approaches. Propensity score matching resulted in sample sizes of 305 nulliparous women in both the individual care (IC) and the matched control group (control‐IC) and 267 in the CP and control‐CP groups. For multiparous women, 354 matches were found for IC and control‐IC groups and 152 for CP and control‐CP groups. Main outcome measures were maternal, birth, and neonatal outcomes.ResultsCompared with the control‐CP group receiving standard antenatal care, nulliparous women participating in CP had a lower risk of maternal hypertensive disorders (odds ratio [OR], 0.53; 95% CI, 0.30‐0.93) and for the composite adverse maternal outcome (OR, 0.52; 95% CI, 0.33‐0.82). Breastfeeding initiation rates were higher amongst nulliparous (OR, 2.23; 95% CI, 134‐3.69) and multiparous women (OR, 1.62; 95% CI, 1.00‐2.62) participating in CP compared with women in the control‐CP group.ConclusionNulliparous women in CP were at lower risk of developing hypertensive disorders during pregnancy and, consequently, at lower risk of having adverse maternal outcomes. The results confirmed our hypothesis that both nulliparous and multiparous women who participated in CP would have higher breastfeeding rates compared with women receiving standard antenatal care.