bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water removal in MR spectroscopic imaging with Casorati singular value decomposition
Authors: Shamaei Amirmohammad , Starcukova Jana , Rizzo Rudy , Starcuk Zenon 
Published: January 2024

AbstractPurposeWater removal is one of the computational bottlenecks in the processing of high‐resolution MRSI data. The purpose of this work is to propose an approach to reduce the computing time required for water removal in large MRS data.MethodsIn this work, we describe a singular value decomposition–based approach that uses the partial position‐time separability and the time‐domain linear predictability of MRSI data to reduce the computational time required for water removal. Our approach arranges MRS signals in a Casorati matrix form, applies low‐rank approximations utilizing singular value decomposition, removes residual water from the most prominent left‐singular vectors, and finally reconstructs the water‐free matrix using the processed left‐singular vectors.ResultsWe have demonstrated the effectiveness of our proposed algorithm for water removal using both simulated and in vivo data. The proposed algorithm encompasses a pip‐installable tool (
https://pypi.org/project/CSVD/), available on GitHub (
https://github.com/amirshamaei/CSVD), empowering researchers to use it in future studies. Additionally, to further promote transparency and reproducibility, we provide comprehensive code for result replication.ConclusionsThe findings of this study suggest that the proposed method is a promising alternative to existing water removal methods due to its low processing time and good performance in removing water signals.
An augmented hybrid multibaseline and referenceless MR thermometry motion compensation algorithm for MRgHIFU hyperthermia
Authors: Wong Suzanne M. , Akbulatov Arthur , Macsemchuk Craig A. , Headrick Andrew , Luo Phoebe , Drake James M. , Waspe Adam C. 
Published: January 2024

AbstractPurposeA hybrid principal component analysis and projection onto dipole fields (PCA‐PDF) MR thermometry motion compensation algorithm was optimized with atlas image augmentation and validated.MethodsExperiments were conducted on a 3T Philips MRI and Profound V1 Sonalleve high intensity focused ultrasound (high intensity focused ultrasound system. An MR‐compatible robot was configured to induce motion on custom gelatin phantoms. Trials with periodic and sporadic motion were introduced on phantoms while hyperthermia was administered. The PCA‐PDF algorithm was augmented with a predictive atlas to better compensate for larger sporadic motion.ResultsDuring periodic motion, the temperature SD in the thermometry was improved from to C with both the original and augmented PCA‐PDF application. For large sporadic motion, the augmented atlas improved the motion compensation from the original PCA‐PDF correction from to C.ConclusionThe PCA‐PDF algorithm improved temperature accuracy to <1°C during periodic motion, but was not able to adequately address sporadic motion. By augmenting the PCA‐PDF algorithm, temperature SD during large sporadic motion was also reduced to <1°C, greatly improving the original PCA‐PDF algorithm.
FGF21 increases the sensitivity of hepatocellular carcinoma to sorafenib under hypoxia
Authors: Zhang Ting , Shi Huiling , Zhang Shihui , Zhu Qin , Qiu Mengyuan , Chitakunye Ashleigh T. , Hong Hanyu , Luo Liaoxin , Li Yujing , Sun Qiuyu , Li Xiaokun , Cai Lin 
Published: January 2024

AbstractBackgroundHepatocellular carcinoma (HCC) is a common disease in human history and one of the main causes of cancer‐related death. Insufficient oxygen supply in the tumor microenvironment forces cancer cells to survive in a mild hypoxia environment. Fibroblast growth factor 21 (FGF21), a member of the FGF family, has become the focus of public attention due to its outstanding achievements in diabetes and lipid lowering. However, the mechanism of FGF21 in HCC remains unclear.ObjectiveThe aims of this study were to clarify whether or not FGF21 could increase the sensitivity of HCC to sorafenib (SORA) under hypoxia and explore the possible mechanism.MethodsIn this study, by using 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide cell viability test, plate clone formation test, western blot analysis, Hoechst/propidium iodide double staining experiment, flow cytometry, quantitative reverse transcription polymerase chain reaction, and subcutaneous tumor transplantation in mice, we studied the effects of recombinant human FGF21 combined with SORA on hepatoma cells in vitro and in vivo. FGF21 could enhance the phosphorylation of mothers against decapentaplegic homolog 3 (Smad3) under anaerobic conditions. When combined with SORA, FGF21 could increase the sensitivity of hepatoma cells to SORA and inhibit the growth and migration of hepatoma cells.ResultsFGF21 may increase the sensitivity of HCC to SORA by enhancing the phosphorylation of Smad3 through the phosphatidylinositol 3‐kinase/protein kinase B pathway under hypoxia.ConclusionOur study suggested the possibility of combination therapy for SORA and FGF21 on HCC.
The agency of “doing something”: Ethnographic research on subject positions at predominantly White institutions
Authors: Wang Chenyu , LaDousa Chaise 
Published: January 2024

AbstractA small elite liberal arts college in the northeastern United States provides a context for the promotion and proliferation of a discourse of diversity, equity, and inclusion. This article considers projects emergent from a summer research fellowship offered to groups of faculty members and students. We compare the ways in which the group of students led by us and the group of students led by another set of faculty developed questions and explored aspects of diversity, equity, and inclusion. We show that the other group began their efforts by foregrounding work on the production of inequality but ended up with a rather neoliberal subjectivity focused on the exploration of the self and one's feelings. Our group managed to avoid such an outcome, but, unlike the other group, our work got passed over for promotion on the College's website. Our insights seek to provide a context for the transformation of calls to “do something” in the academic institution in which we work into depoliticized representations of difference ripe for institutional display and promotion.
How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI‐RS 2023: Part 1
Authors: Finazzi Agrò Enrico , Rosato Eleonora , Wagg Adrian , Sinha Sanjay , Fede Spicchiale Claudia , Serati Maurizio , Mancini Vito , de Rijk Mathijs , Tarcan Tufan , Wein Alan , Abrams Paul , Bou Kheir George 
Published: January 2024

AbstractIntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one‐size‐fits‐all approach.
How do we make progress in phenotyping patients with lower urinary tract such as overactive bladder and underactive detrusor, including using urine markers and microbiome data, to personalize therapy? ICI‐RS 2023—Part 2
Authors: Finazzi Agrò Enrico , Rosato Eleonora , Wagg Adrian , Sinha Sanjay , Fede Spicchiale Claudia , Serati Maurizio , Mancini Vito , de Rijk Mathijs , Tarcan Tufan , Wein Alan , Abrams Paul , Bou Kheir George 
Published: January 2024

AbstractIntroductionOveractive bladder (OAB) and underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU using urodynamic tests, functional neuro‐imaging, urinary markers, and microbiome.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract (LUT) symptoms, such as OAB and UAB. The intricate interplay between the LUT and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one‐size‐fits‐all approach.
The antecedents of conformity in an institutionalized federated system: The case of local united ways
Authors: Hwang Hyunseok , LePere‐Schloop Megan , You Wenpei , Paarlberg Laurie E. 
Published: January 2024

AbstractTo what extent do organizations conform to external pressures within a highly institutionalized federated system? Drawing on the theory of middle‐status conformity, and distinguishing between ascribed and achieved status, we examine variation in linguistic conformity across the United Way (UW) system. Using a unique set of data collected from multiple sources, we analyzed the effect of both ascribed status (age) and achieved status (fundraising performance) on local UW conformity to the community impact language of the United Way Worldwide (UWW). We found a curvilinear relationship between linguistic conformity and achieved status but not ascribed status. Local UWs with achieved middle status based on fundraising performance were more likely to conform to the UWW's community impact language than low and high‐status local UWs. The presence of a state UW association moderated the relationship between achieved status and linguistic conformity. This study contributes a novel conceptualization and operationalization of organizational conformity, refines the theory of middle‐status conformity by distinguishing two types of status in the context of a highly institutionalized federated system, and examines moderating conditions of middle‐status conformity.
Commentary on the role of polyoxometalates in nature cybernetic loop
Authors: Monakhov Kirill Yu. 
Published: January 2024

AbstractThe interplay between extraterrestrial, atmospheric, aqueous, interfacial, and hydrothermal processes is crucial for Earth's prebiotic chemistry. Volcanic terrains contain polyoxometalates (POMs). Some polyoxocuprates were identified as building blocks of fumarole minerals produced from high‐temperature gases. The existence of polyoxovanadate anions in acidified reducing volcanic aquifers cannot be excluded. At present, it can only be speculated whether life arose around natural POM deposits and/or around their aqueous phase chemistry through acid‐base and/or redox reactions. This Commentary spans different fields of sciences in nature cybernetic loop to provide impetus to explore gas‐phase chemical reactions of multiply charged POM ions, catalysis by POM‐containing mineral phases, the behavior of POMs under plasma‐initiated ultraviolet photolysis, interactions of POMs with microorganisms, bioorthogonal chemistry of POMs, and engineering POM‐based bionic functions inspired by living organisms.
The individual‐level effects of social media campaigns related to healthy eating, physical activity, and healthy weight: A narrative review
Authors: Luo Yajing , Maafs‐Rodríguez Ana G. , Hatfield Daniel P. 
Published: January 2024

AbstractObjectiveSocial media are promising channels for health communication promoting positive weight‐related behaviors, but no prior studies have synthesized evidence on the independent effects of social media campaigns focused on promoting healthy eating, physical activity (PA), and healthy weight. This study aimed to fill that gap and inform future social media‐based obesity‐prevention research and practice by reviewing findings from studies testing the effects of such campaigns on individual‐level cognitive, behavioral, and anthropometric outcomes.MethodThe Web of Science and PubMed databases were searched for peer‐reviewed articles published between 2012 and 2023 that explored the independent effects of social media campaigns related to healthy eating, PA, or weight management. Study characteristics and outcomes were extracted and summarized.ResultsEleven studies were included in this review describing campaigns targeting healthy eating‐related outcomes (e.g., fruit and vegetable consumption, meal preparation, nutrition label reading), PA, or weight management. Most campaigns (n = 7) were developed by universities or research centers. Priority audiences included parents, adult females, adolescents, college students, and adult government employees. The majority (n = 8) of the campaigns used single platforms, with the most common being Facebook, Instagram, blogs, and YouTube. Campaigns had mixed effects on cognitive outcomes (e.g., intention, attitude, knowledge), behavioral outcomes (e.g., food choices, PA), and anthropometric outcomes (e.g., weight, waist circumference).ConclusionSocial media campaigns focused on promoting healthy eating, PA, and healthy weight had mixed effects on individual‐level cognitive, behavioral, and anthropometric outcomes. Various limitations of the included studies make it difficult to ascertain which factors influence campaign effectiveness. Advancing knowledge in this area is important, particularly given social media's widespread use and potential for broad reach. New research with features such as rigorous study designs, larger and more diverse samples, and strong theoretical foundations may provide important insights into what types of interventions are effective or not and under what conditions.
Mutational signature and prognosis in adenocarcinoma of the bladder
Authors: Yang Guoliang , Shahatiaili Akezhouli , Bai Shihao , Wang Liyang , Jin Di , Cao Ming , Su Peipei , Liu Qiang , Tao Kun , Long Qi , Shi Yi , Xiao Jing , Tian Futong , Zhang Lianhua , Chen Haige , Su Xianbin 
Published: January 2024

AbstractAdenocarcinoma of the bladder is a rare urinary bladder carcinoma with limited therapy options due to lack of molecular characterization. Here, we aimed to reveal the mutational and transcriptomic landscapes of adenocarcinoma of the bladder and assess any relationship with prognosis. Between February 2015 and June 2021, a total of 23 patients with adenocarcinoma of the bladder were enrolled. These included 16 patients with primary bladder adenocarcinomas and seven patients with urachal adenocarcinoma. Whole exome sequencing (16 patients), whole genome sequencing (16 patients), bulk RNA sequencing (RNA‐seq) (19 patients), and single‐cell RNA‐seq (5 patients) were conducted for the specimens. Correlation analysis, survival analysis, and t‐tests were also performed. Prevalent T>A substitutions were observed among somatic mutations, and major trinucleotide contexts included 5’‐CTC‐3’ and 5’‐CTG‐3’. This pattern was mainly contributed by COSMIC signature 22 related to chemical carcinogen exposure (probably aristolochic acid), which has not been reported in bladder adenocarcinoma. Moreover, genes with copy number changes were also enriched in the KEGG term ‘chemical carcinogenesis’. Transcriptomic analysis suggested high immune cell infiltration and luminal‐like features in the majority of samples. Interestingly, a small fraction of samples with an APOBEC‐derived mutational signature exhibited a higher risk of disease progression compared with samples with only a chemical carcinogen‐related signature, confirming the molecular and prognostic heterogeneity of bladder adenocarcinoma. This study presents mutational and transcriptomic landscapes of bladder adenocarcinoma, and indicates that a chemical carcinogen‐related mutational signature may be related to a better prognosis compared with an APOBEC signature in adenocarcinoma of the bladder. © 2024 The Pathological Society of Great Britain and Ireland.
Integrated transcriptomic landscape of the effect of anti‐steatotic treatments in high‐fat diet mouse models of non‐alcoholic fatty liver disease
Authors: Fuster‐Martínez Isabel , Català‐Senent José F , Hidalgo Marta R , Roig Francisco J , Esplugues Juan V , Apostolova Nadezda , García‐García Francisco , Blas‐García Ana 
Published: January 2024

AbstractHigh‐fat diet (HFD) mouse models are widely used in research to develop medications to treat non‐alcoholic fatty liver disease (NAFLD), as they mimic the steatosis, inflammation, and hepatic fibrosis typically found in this complex human disease. The aims of this study were to identify a complete transcriptomic signature of these mouse models and to characterize the transcriptional impact exerted by different experimental anti‐steatotic treatments. For this reason, we conducted a systematic review and meta‐analysis of liver transcriptomic studies performed in HFD‐fed C57BL/6J mice, comparing them with control mice and HFD‐fed mice receiving potential anti‐steatotic treatments. Analyzing 21 studies broaching 24 different treatments, we obtained a robust HFD transcriptomic signature that included 2,670 differentially expressed genes and 2,567 modified gene ontology biological processes. Treated HFD mice generally showed a reversion of this HFD signature, although the extent varied depending on the treatment. The biological processes most frequently reversed were those related to lipid metabolism, response to stress, and immune system, whereas processes related to nitrogen compound metabolism were generally not reversed. When comparing this HFD signature with a signature of human NAFLD progression, we identified 62 genes that were common to both; 10 belonged to the group that were reversed by treatments. Altered expression of most of these 10 genes was confirmed in vitro in hepatocytes and hepatic stellate cells exposed to a lipotoxic or a profibrogenic stimulus, respectively. In conclusion, this study provides a vast amount of information about transcriptomic changes induced during the progression and regression of NAFLD and identifies some relevant targets. Our results may help in the assessment of treatment efficacy, the discovery of unmet therapeutic targets, and the search for novel biomarkers. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
The fifth edition of the WHO classification of mature B‐cell neoplasms: open questions for research
Authors: Coupland Sarah E , Du Ming‐Qing , Ferry Judith A , de Jong Daphne , Khoury Joseph D , Leoncini Lorenzo , Naresh Kikkeri N , Ott German , Siebert Reiner , Xerri Luc ,   the WHO 5th Edition Classification Project
Published: January 2024

AbstractThe fifth edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO‐HAEM5) is the product of an evidence‐based evolution of the revised fourth edition with wide multidisciplinary consultation. Nonetheless, while every classification incorporates scientific advances and aims to improve upon the prior version, medical knowledge remains incomplete and individual neoplasms may not be easily subclassified in a given scheme. Thus, optimal classification requires ongoing study, and there are certain aspects of some entities and subtypes that require further refinements. In this review, we highlight a selection of these challenging areas to prompt more research investigations. These include (1) a ‘placeholder term’ of splenic B‐cell lymphoma/leukaemia with prominent nucleoli (SBLPN) to accommodate many of the splenic lymphomas previously classified as hairy cell leukaemia variant and B‐prolymphocytic leukaemia, a clear new start to define their pathobiology; (2) how best to classify BCL2 rearrangement negative follicular lymphoma including those with BCL6 rearrangement, integrating the emerging new knowledge on various germinal centre B‐cell subsets; (3) what is the spectrum of non‐IG gene partners of MYC translocation in diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma and how they impact MYC expression and clinical outcome; how best to investigate this in a routine clinical setting; and (4) how best to define high‐grade B‐cell lymphoma not otherwise specified and high‐grade B‐cell lymphoma with 11q aberrations to distinguish them from their mimics and characterise their molecular pathogenetic mechanism. Addressing these questions would provide more robust evidence to better define these entities/subtypes, improve their diagnosis and/or prognostic stratification, leading to better patient care. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Feasibility and antitumour activity of the FGFR inhibitor erdafitnib in three paediatric CNS tumour patients
Authors: Stepien Natalia , Mayr Lisa , Schmook Maria T. , Raimann Adalbert , Dorfer Christian , Peyrl Andreas , Azizi Amedeo A. , Schramm Kathrin , Haberler Christine , Gojo Johannes 
Published: January 2024

AbstractAlterations of the fibroblast growth factor (FGF) signalling pathway are increasingly recognized as frequent oncogenic drivers of paediatric brain tumours. We report on three patients treated with the selective FGFR1–4 inhibitor erdafitinib. Two patients were diagnosed with a posterior fossa ependymoma group A (PFA EPN) and one with a low‐grade glioma (LGG), harbouring FGFR3/FGFR1 overexpression and anFGFR1internal tandem duplication (ITD), respectively. While both EPN patients did not respond to erdafitinib treatment, theFGFR1‐ITD‐harbouring tumour showed a significant decrease in tumour volume and contrast enhancement throughout treatment. The tumour remained stable 6 months after treatment discontinuation.
Mammalian target of rapamycin inhibitors: A new‐possible approach for in‐utero medication therapy
Authors: Qaderi Shohra , Javinani Ali , Blumenfeld Yair J. , Krispin Eyal , Papanna Ramesha , Chervenak Frank A. , Shamshirsaz Alireza A. 
Published: January 2024

AbstractThe mammalian/mechanistic target of rapamycin (mTOR) is a protein kinase that plays a crucial role in regulating cellular growth, metabolism, and survival. Although there is no absolute contraindication for the use of mTOR inhibitors during pregnancy, the specific fetal effects remain unknown. Available data from the past 2 decades have examined the use of mTOR inhibitors during pregnancy in patients with solid organ transplantation, showing no clear link to fetal complications or structural abnormalities. Recently, a handful of case reports and series have described transplacental therapy of mTOR inhibitors to control symptomatic and complicated pathologies in the fetus. The effect of these agents includes a significant reduction in lesion size in the fetus and a reduced need for mechanical ventilation in neonates. In this context, we delve into the potential of mTOR inhibitors as in‐utero therapy for fetal abnormalities, with a primary focus on lymphatic malformation (LM) and cardiac rhabdomyoma (CR). While preliminary reports underscore the efficacy of mTOR inhibitors for the treatment of fetal CR and fetal brain lesions associated with tuberous sclerosis complex, chylothorax, and LMs, additional investigation and clinical trials are essential to comprehensively assess the safety and efficacy of these medications.