bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Pregnancy Complication (Preeclampsia) Is Associated With Greater Periodontal Destruction
Authors: Oettinger‐Barak Orit , Barak Shlomi , Ohel Gonen , Oettinger Moshe , Kreutzer Harald , Peled Micha , Machtei Eli E. 
Published: March 2005

Background: Preeclampsia is a pregnancy‐specific disease which is one of the leading causes of maternal and fetal morbidity and mortality. The etiology of preeclampsia remains elusive. The underlying pathology may be related to a generalized intravascular hyperinflammatory state. Since the placental histopathologic lesions of acute atherosis, seen in preeclampsia, bear resemblance to those seen in atherosclerosis, and recent evidence links atherosclerosis with chronic infection, we decided to investigate a possible link between preeclampsia and chronic periodontal infection.Methods: Thirty primigravidas, 15 suffering from preeclampsia, had full mouth periodontal examinations. Gingival crevicular fluid samples were taken for laboratory immunological assessment. Similar examination and sampling were performed in 15 age‐ and maternal status‐matched controls.Results: Significantly higher periodontal probing depth and clinical attachment level scores were found in the preeclamptic group compared with controls (2.98 versus 2.11 and 3.33 versus 2.30, respectively). Plaque index, gingival index, and mean gingival overgrowth scores were very similar in both groups. Furthermore, prostaglandin E2 (PGE2), tumor necrosis factor (TNF)‐ α, and interleukin (IL)‐1 β levels were all significantly higher in the preeclamptic group (247.4 ngr/sample versus 89.1 ngr/sample, 8.03 pgr/sample versus 4.03 pgr/sample, and 175.7 pgr/sample versus 62.2 pgr/sample, respectively).Conclusion: The above results suggest a possible association between periodontal inflammation and preeclampsia. J Periodontol 2005;76:134‐137.
Alveolar Bone Necrosis and Tooth Exfoliation Following Herpes Zoster Infection: A Review of the Literature and Case Report
Authors: Mendieta C. , Miranda J. , Brunet L.l. , Gargallo J. , Berini L. 
Published: March 2005

Background: Herpes zoster (HZ) presents as a cutaneous vesicular eruption in the area innervated by the affected sensory nerve, usually associated with severe pain. Oral manifestations of HZ appear when the mandibular or maxillary divisions of the trigeminal nerve are affected.Methods: This is a case report of a 63‐year‐old woman with HZ infection with trigeminal nerve involvement that led to a rapid loss of alveolar bone and exfoliation of two teeth.Results: The initial intraoral examination showed redness of the alveolar mucosa and gingiva of the lower right quadrant with multiple well‐delimited and painful erosive lesions affecting the attached gingiva around the teeth. Two weeks later, teeth number 27 (lower right canine) and 28 (lower right first premolar) had class III mobility, flow of purulent exudate from the gingival sulcus, and deep pockets ( >11 mm). The radiological examination showed advanced alveolar bone loss around both teeth. The prognosis for teeth number 27 and 28 was considered hopeless, and they were extracted. Due to extensive necrosis there was no interdental alveolar bone. The case is presented with a review of clinical data from patients with trigeminal HZ infection associated with osteonecrosis or exfoliation of teeth previously reported in the literature. The mechanisms by which the HZ infection leads to the alveolar bone necrosis are discussed.Conclusions: Extensive osteonecrosis and exfoliation of teeth in the area innervated by the nerve affected by HZ has been reported after HZ infection. Clinicians should be aware of this possible outcome after a trigeminal HZ infection. J Periodontol 2005;76:148‐153.
Comparative Evaluation of Decalcified and Non‐Decalcified Freeze‐Dried Bone Allografts in Rhesus Monkeys. I. Histologic Findings
Authors: Yukna Raymond A. , Vastardis Sotirios 
Published: March 2005

Background: Controversy exists regarding the relative merits of decalcified (DFDBA) and non‐decalcified (FDBA) freeze‐dried bone allografts when used in periodontal or other oral surgical procedures.Methods: Under typical sedation, six rhesus monkeys had nylon mesh cylinders containing either DFDBA or FDBA implanted into surgically created vertical grooves on the facial aspects of all posterior quadrants. Each quadrant received three cylinders containing one type of bone, plus one empty cylinder (E) as negative control, and the full thickness flaps were closed to completely cover the cylinders. Cylinders were retrieved at 1, 2, and 3 months and processed for histologic evaluation. Photomicrographs taken at 8x were randomly evaluated using a histometric grid point counting technique for new bone and old bone within the chambers, and the data were analyzed with analysis of variance plus post‐tests.Results: The nylon chambers and their contents were well‐tolerated by the tissues. FDBA chambers contained more new bone and total bone than either the DFDBA or E chambers at all time periods (P <0.05). DFDBA was not statistically significantly different than E at any time period. FDBA had less old bone than DFDBA at 3 months (P <0.05). FDBA and DFDBA had more total bone (grafted plus new) present than E at all time periods (P <0.05).Conclusion: These results suggest that FDBA may stimulate earlier, more rapid, and more substantial new bone formation than DFDBA in a monkey jaw defect model system. J Periodontol 2005;76:57‐65.
Increased Interleukin‐18 in Patients With Juvenile Idiopathic Arthritis and Early Attachment Loss
Authors: Miranda Leticia A. , Fischer Ricardo G. , Sztajnbok Flavio R. , Johansson Anders , Figueredo Carlos Marcelo S. , Gustafsson Anders 
Published: March 2005

Background: Patients with juvenile idiopathic arthritis (JIA) have been shown to have incipient attachment loss (AL) more frequently than systemically healthy individuals. This study investigated neutrophil activity and proinflammatory cytokines in these patients and aged‐matched controls.Methods: Elastase activity, measured with a low molecular weight substrate (S‐2484), and interleukin‐1β (IL‐1β), measured with the enzyme‐linked immunosorbent assay (ELISA), were analyzed in the gingival fluid of 38 patients with JIA and 29 controls. IL‐1β and interleukin‐18 (IL‐18) were measured with ELISA in the serum of the same groups. Subgingival plaque was analyzed by DNA probes to detect 12 bacteria.Results: Significantly elevated serum levels of IL‐1β and IL‐18 were found in the JIA group. No differences were found in the gingival fluid levels of elastase and IL‐1β between groups, or in the frequency of subjects positive to most of the bacteria analyzed, except F. nucleatum, C. rectus, P. micros, and S. intermedius, which were significantly more frequent in the control group. When the JIA group was subdivided according to the presence/absence of AL, IL‐18 was significantly increased in the JIA subgroup with AL compared to those without it. There were no differences in the subgingival microbiota between the subgroups.Conclusion: The findings of increased serum IL‐18 and IL‐1β in patients with JIA accompanied by a similar subgingival microbiota suggest that the increased frequency of incipient attachment loss observed in these patients might be due to their altered systemic inflammatory response, making them more susceptible to periodontal disease. J Periodontol 2005;76:75‐82.
Collagen Fiber Orientation in Human Peri‐Implant Bone Around Immediately Loaded and Unloaded Titanium Dental Implants
Authors: Traini Tonino , Degidi Marco , Caputi Sergio , Strocchi Rita , Di Iorio Donato , Piattelli Adriano 
Published: March 2005

Background: The main factor in determining the mechanical properties of bone is the collagen configuration.Methods: This study investigated the birefringence in human bone around loaded and unloaded titanium dental implants to evaluate the collagen fiber orientation using circularly polarized light (CPL) and scanning electron microscopy (SEM). A total of 10 titanium dental implants, five immediately loaded and five unloaded, were used. The birefringence measurements were performed on digitized images of both loaded and unloaded implants. All images detected at 50x were measured using a software image analysis.Results: In the bone around loaded implants, the transverse collagen fiber area was 45,481 ± 3,037 pixel2 (mean ± SD), while the area of longitudinal collagen fibers was 13,676 ± 2,232 pixel2 (mean ± SD). In the unloaded implants, the transverse collagen fiber area was 32,174 ± 2,554 pixel2 (mean ± SD), while the area of longitudinal collagen fibers was 89,073 ± 1,960 pixel2 (mean ± SD). The CPL measurements of the birefringence for transverse collagen fibers of loaded versus unloaded implants indicated that the differences were statistically significant (P <0.05). The results for the longitudinal collagen fibers of loaded versus unloaded implants were also statistically significant (P <0.05).Conclusions: In the bone around loaded dental implants, transverse collagen fibers were more abundant, while in the unloaded implants, collagen fibers run more longitudinally. The load seemed to determine the collagen fiber orientation.J Periodontol 2005;76:83‐89.
Individual and Combined Effects of Selective Cyclooxygenase‐2 Inhibitor and Omega‐3 Fatty Acid on Endotoxin‐Induced Periodontitis in Rats
Authors: Vardar Saynur , Buduneli Eralp , Baylas Haluk , Hüseyinov Berdeli Afig , Buduneli Nurcan , Atilla Gül 
Published: March 2005

Background: The present study was planned to evaluate the individual and combined effects of selective cyclooxygenase‐2 (COX‐2) inhibitor, celecoxib, and omega‐3 fatty acid on the gingival tissue levels of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α), leukotriene B4 (LTB4), and platelet activating factor (PAF) in endotoxin‐induced periodontitis in rats.Methods: Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS). Forty‐four adult male Sprague‐Dawley rats were divided into five study groups: saline control, LPS, celecoxib, omega‐3 fatty acid, and combination celecoxib and omega‐3 fatty acid. Celecoxib and omega‐3 fatty acid were given either as a single agent or as a combination therapy during 14 days of the study period. At the end of the 2‐week protocol, the rats were sacrificed, the gingival tissues were dissected and extracted, and the extracts were analyzed for PGE2, PGF2α, and LTB4 levels by enzyme immunoassay and for PAF levels by radioimmunoassay. The defleshed jaws were analyzed morphometrically for alveolar bone loss. Data were evaluated statistically by using parametric tests.Results: LPS injection resulted in significantly more bone loss than the saline controls (P <0.05) and significant elevations in the gingival tissue levels of all the analyzed mediators except PGF2α. Individual administration of celecoxib revealed significant reductions in PGE2 and PAF levels (P <0.05), while omega‐3 fatty acid provided significant reduction in PGE2, PGF2α, and LTB4 levels compared to the LPS group (P <0.05). Combined administration of celecoxib and omega‐3 fatty acid exhibited significantly lower values than those of the LPS group in all the analyzed membrane phospholipid mediators (P <0.05), which approximated the levels in the saline control group (P >0.05).Conclusions: The results of the present study indicate that celecoxib and omega‐3 fatty acid, when used individually, show a rather partial effect on the control of the analyzed mediators, but when combined they show a synergic effect and provide significant reductions in the gingival tissue levels of PGE2, PGF2α, LTB4, and PAF in LPS‐induced experimental periodontitis. These findings may pioneer further clinical human studies investigating the possible place of celecoxib and omega‐3 fatty acid in periodontal treatment. J Periodontol 2005;76:99‐106.
Fibular aplasia, tibial campomelia, and oligosyndactyly in a male newborn infant: A case report and review of the literature
Authors: Courtens Winnie , Jespers Ann , Harrewijn Inge , Puylaert Dirk , Vanhoenacker Filip 
Published: March 2005

AbstractWe report on a male newborn with a rarely described congenital limb deficiency syndrome consisting of shortening and anterior bowing of the right lower limb at the distal third of the tibia with associated overlying soft tissue dimpling, oligodactyly of the right foot, and a left‐sided oligosyndactyly of the hand. The right hand and left lower limb were clinically normal. Radiographic examination revealed complete absence of the right fibula, absence of the right‐sided Vth ray, and anterior bowing and shortening of the right‐sided tibia. Femora, humeri, ulnae, and radii were normal. The infant had neither facial dysmorphia nor other associated anomalies. A limb deficiency syndrome comparable to this case has been reported in a female by Hecht and Scott [1981; Clin Genet 20:432–437], the only report classified under OMIM 246570 so far. We found two other reports describing three cases comparable to our case and the female reported by Hecht and Scott [1981], and reviewed these cases. The major common findings in all the five cases consist of fibular aplasia, tibial campomelia, and oligosyndactyly. Therefore, we propose to name it fibular aplasia‐tibial campomelia‐oligosyndactyly (FATCO) syndrome. Additional case reports are needed for further delineation of this rare limb deficiency syndrome. © 2005 Wiley‐Liss, Inc.
Gastric juvenile polyposis associated with germline SMAD4 mutation
Authors: Shikata Kentaro , Kukita Yoji , Matsumoto Takayuki , Esaki Motohiro , Yao Takashi , Mochizuki Yuichi , Hayashi Kenshi , Iida Mitsuo 
Published: March 2005

AbstractWe treated a 39‐year‐old woman with hypoproteinemia and anemia who had profuse gastric polyposis. Radiographic and endoscopic examination showed numerous polyps restricted to the stomach. The patient had pulmonary arteriovenous malformations in the left lung. Histological examination of the resected stomach revealed the gastric polyposis to be composed of cystic dilatation of the glands with small areas of adenocarcinoma. These findings were compatible with gastric juvenile polyposis (GJP) accompanied by gastric cancer. Analysis of genomic DNA revealed that the patient had truncating mutation of SMAD4, a responsible gene for juvenile polyposis (JP). Our case suggests that SMAD4 is possibly a responsible gene for GJP. © 2005 Wiley‐Liss, Inc.
Rapid array‐based genomic characterization of a subtle structural abnormality: A patient with psychosis and der(18)t(5;18)(p14.1;p11.23)
Authors: Drazinic Carolyn M. , Ercan‐Sencicek Adife G. , Gault Laura M. , Hisama Fuki M. , Qumsiyeh Mazin B. , Nowak Norma J. , Cubells Joseph F. , State Matthew W. 
Published: March 2005

AbstractArray‐based copy number analysis has recently emerged as a rapid means of mapping complex and/or subtle chromosomal abnormalities. We have compared two such techniques, using bacterial artificial chromosome (BAC) and single nucleotide polymorphism (SNP) arrays in the evaluation of a 45‐year‐old woman with dysmorphic features, mental retardation, psychosis, and an unbalanced derivative chromosome 18, (46,XX, der(18)t(18;?)(p12;?)). Both array‐based methods demonstrated that the additional material on chromosome 18 was of 5p origin. The 5p duplication mapped telomeric to 25.320 Mb (BAC array) and 25.607 Mb (SNP array), corresponding to the band 5p14.1. Both BAC and SNP arrays also showed a deletion involving chromosome 18p extending telomeric from 8.437 Mb (BAC array) and 8.352 Mb (SNP array), corresponding to the band 18p11.23. Molecular cytogenetic mapping using fluorescence in situ hybridization (FISH) supported the array findings and further refined the breakpoint regions, confirming that the BAC and SNP chips were both useful in this regard. Both case reports and linkage analyses have implicated these chromosomal intervals in psychosis. The array‐based experiments were completed over the course of several days. While these methods do not eliminate the requirement for traditional fine‐mapping, they provide an efficient approach to identifying the origin and extent of deleted and duplicated material in chromosomal rearrangements. © 2005 Wiley‐Liss, Inc.
Synthesis and Antiapoptotic Activity of a Novel Analogue of the Neutral Sphingomyelinase Inhibitor Scyphostatin
Authors: Claus Ralf A. , Wüstholz Annette , Müller Stefan , Bockmeyer Clemens L. , Riedel Norman H. , Kinscherf Ralf , Deigner Hans‐Peter 
Published: March 2005

AbstractThe enantioselective synthesis of an analogue of scyphostatin, a potent inhibitor of the neutral sphingomyelinase, is described. The synthesis starts with cyclohexanone and a protected D‐serine derivative. The key step is an asymmetric hydroxylation to access a hydroxycyclohexanone, which is transformed into a substituted hydroxycyclohexenone. This is converted into the scyphostatin analogue 14, a chemically and metabolically stabilised compound lacking the epoxy function of the natural congener and carrying a palmitic acid group instead of the native trienoyl residue. An evaluation of the biological activity of 14 revealed neutral sphingomyelinase inhibition in several in vivo test systems (monocytes, macrophages, hepatocytes) monitoring antiapoptotic effects and the inversion of phorbolester‐induced translocation of green fluorescent protein labelled kinase (protein kinase C‐α).
Efficient Oxidation of Aromatics with Peroxides under Severe Conditions Using a Microreaction System
Authors: Yube K. , Mae K. 
Published: March 2005

AbstractOxidation of 2‐methylnaphthalene was performed as a model reaction under severe conditions in order to develop operation strategies for highly efficient oxidation of aromatics. A microreactor system was used which allows oxidation reactions to be carried out under conditions which cannot be realized by conventional approaches. Owing to the good heat transfer performance and rapid mixing technology, it is possible to increase reaction temperature and add oxidants at considerably higher concentrations than in traditional semibatch processes. The selectivity of the desired product, 2‐methyl‐1,4‐naphthoquinone, increased to 50 % via the suppression of consecutive side reactions by controlling a short residence time at a high temperature. It was clarified that microreaction systems provide a new route to precisely control the oxidation of aromatics.
Integration of Microreaction Technology into the Curriculum
Authors: Gorges R. , Taubert T. , Klemm W. , Scholz P. , Kreisel G. , Ondruschka B. 
Published: March 2005

AbstractAs a pioneer in Germany, the Institute of Technical Chemistry and Environmental Chemistry at the Friedrich Schiller University in Jena has integrated microreaction technology into its curriculum of industrial chemistry. This essay describes how traditional lab classes in industrial chemistry are replaced or supplemented by microreaction components. It is shown how lab classes on heat transfer, heterogeneous catalysis, mixing and stirring, and photochemistry were modified to meet this objective. In addition to the practical training in different lab classes, microreaction technology was also implemented in lectures, and thus the knowledge about the various possibilities and advantages of this new technology is instilled in future generations of chemists at an early stage of their education.
A μ‐Fluidic Mixing Network
Authors: Baier T. , Drese K. S. , Schönfeld F. , Schwab U. 
Published: March 2005

AbstractThe simulation, fabrication and experimental characterization of a fluidic network of planar micro mixers utilizing chaotic advection induced by Dean vortices are presented. The approach allows realization of specific networks which provide dilution series of two or more fluids. As an example, a mixer network is analyzed where two inlet streams are mixed in ratios 1:2m (m = 1, ..., 5). The layout is performed by means of a network model which is based on detailed computational fluid dynamic simulations.
Organic Synthesis with Microstructured Reactors
Authors: Hessel V. , Löwe H. 
Published: March 2005

AbstractThis article describes the opportunities microstructured reactors offer for chemical plant engineering. This suitability for chemical production is commonly regarded to be the key to market penetration. Century‐long practices with batch‐type stirring and, correspondingly, the existence of capital‐intensive large‐scale plants, hinder an easy and fast implementation of chemical micro process engineering. Seen in the long term, there is potential that new plants can be equipped with microstructured reactors. Only economic balances, however, which draw up profitability, will open the door to the usage of chemical micro process engineering for plant construction. The main arguments for using microstructured reactors are enhanced conversion and selectivity, increased space‐time yields, waste reduction and better safety given the small reactor volumes. Credit‐card sized reaction systems allow one to perform the screening of multi‐step reactions in one run. Even more impressively, similar screening is carried out for single‐step reactions faster and more reliably. Moreover, safe processing with microstructured reactors in the explosive regime enlarges the traditional range of processing. The reaction guidance by microstructured reactors can further influence subsequent processing steps, such as product purification, and in this way can lower the energy costs of processes.
The Structure of Hormaomycin and One of Its All‐Peptide Aza‐Analogues in Solution: Syntheses and Biological Activities of New Hormaomycin Analogues
Authors: Reinscheid Uwe M. , Zlatopolskiy Boris D. , Griesinger Christian , Zeeck Axel , de Meijere Armin 
Published: March 2005

AbstractFour new aza‐analogues of hormaomycin1, a secondary metabolite with interesting biological activities produced byStreptomyces griseoflavus, were synthesized and subjected to preliminary tests of their antibiotic activity to provide new insights into the structure–activity relationship studies of this class of compounds. The solution structures of hormaomycin1and its aza‐analogue2 awere determined by NMR spectroscopy. The data exhibited a reasonably rigid conformation for both molecules, stabilized by stacking interactions between the aromatic moieties attached to the ring and the side chain. According to NMR‐spectral data the aza‐analogueepi‐2 ahas a rather different conformation and indeed shows no antibacterial activity whatsoever.