bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship between Social Participation and Cognitive Function in Older Adults: The Mediating Role of Activities of Daily Living
Authors: Zhang Chong , Xiong Juan , Luo Wenqi 
Published: February 2024

Abstract
Background
Cognitive impairments are commonly observed in older adults, and there is an increasing number of older adults experiencing cognitive difficulties. Social participation plays a crucial role in promoting active aging, but its relationship with the cognitive function of older adults still needs further confirmation.
Methods
Based on the panel data from the 5 waves of Chinese Longitudinal Healthy Longevity Survey (CLHLS), this study uses fixed-effect model, propensity score matching and mediation analysis to explore the relationship between social participation and cognitive function in older adults
Results
After adjusting the confounders, social participation is positively associated with cognitive function in older adults (β = 1.65, P < 0.001). Specifically, self-entertainment-type social participation shows the strongest positive association (β = 1.09, P < 0.001), followed by household labor-type social participation (β = 0.58, P < 0.001), while the impact of group interaction-type social participation is the weakest (β = 0.47, P < 0.001). Activities of daily living (ADL) mediates the relationship between social participation and cognitive function in older adults, with the strongest mediating effect in the impact of household labor-type social participation.
Limitations
Our study focuses on Chinese participants, so the findings may not apply globally due to varying social habits. The research doesn't account for potentially confounding factors that affect cognitive function. The survey's limited social participation questions may not accurately depict daily life.
Conclusions
Research suggests that social participation significantly predicts cognitive function in older adults. Thus, encouraging various social activities may effectively prevent cognitive decline.
Quaternion-based finite element computation of nonlinear modes and frequency responses of geometrically exact beam structures in three dimensions
Authors: Debeurre Marielle , Grolet Aurélien , Thomas Olivier 
Published: February 2024

Abstract

In this paper, a novel method for computing the nonlinear dynamics of highly flexible slender structures in three dimensions (3D) is proposed. It is the extension to 3D of a previous work restricted to in-plane (2D) deformations. It is based on the geometrically exact beam model, which is discretized with a finite element method and solved entirely in the frequency domain with a harmonic balance method (HBM) coupled to an asymptotic numerical method (ANM) for continuation of periodic solutions. An important consideration is the parametrization of the rotations of the beam's cross sections, much more demanding than in the 2D case. Here, the rotations are parametrized with quaternions, with the advantage of leading naturally to polynomial nonlinearities in the model, well-suited for applying the ANM. Because of the HBM-ANM framework, this numerical strategy is capable of computing both the frequency response of the structure under periodic oscillations and its nonlinear modes (namely its backbone curves and deformed shapes in free conservative oscillations). To illustrate and validate this strategy, it is used to solve two 3D deformations test cases of the literature: a cantilever beam and a clamped-clamped beam subjected to one-to-one (1:1) internal resonance between two companion bending modes in the case of a nearly square cross section.
A new faba bean protein supplement: development and sensory assessment
Authors: Barbosa Priscila Dabaghi , Vilela Regina Maria , Mellinger Caroline , Berté Kleber , Costa Ligia Alves da 
Published: February 2024

Abstract
Pulses have nutritional properties and are known as functional foods due to their content of bioactive compounds. The aim of this research was to develop a protein supplement as a shake, made from commercial faba bean (Vicia faba L.) protein concentrate and natural ingredients and evaluate its acceptability. For that, a shake was prepared from faba bean protein concentrate (Vicia faba L.), whose aminogram was evaluated by ion exchange chromatography and its acceptability evaluated through sensorial tests, using as controls a shake based on vegetable protein and a whey protein. The faba bean protein formulation is sufficient in 7 of the 10 essential amino acids evaluated. The sensory tests showed that the faba bean protein was better evaluated in terms of appearance, color, and aroma as compared to the control samples. The whey protein was better evaluated in terms of flavor and texture, which can be explained by the gritty texture and beany flavor characteristic of legumes, however, there was no significant difference in the preference ordering test, hedonic scale, and purchase intention.
Prevalence of nasopharyngeal myiasis in roe deer (Capreolus capreolus) from an area with high sympatry between wild and domestic ungulates in Central Spain
Authors: Martínez-Calabuig Néstor , Panadero Rosario , Varas Gonzalo , Remesar Susana , López Ceferino M. , Saldaña Ana , Díaz Pablo , Díez-Baños Pablo , Morrondo Patrocinio , García-Dios David 
Published: February 2024

Abstract

Infection by the sheep bot flyOestrus ovis was firstly reported in a single roe deer from Central Spain in 2023. In order to confirm whether that finding was an isolated event or a spillover of O. ovis to a new host, nasopharyngeal cavities of 184 roe deer hunted in Central Spain between January-June 2023 were examined. All larvae were recovered and morphologically identified; in addition, species identification was molecularly confirmed in a subset of specimens.
Forty-four roe deer (23.9%; CI 95 17.95-30.74) were positive for different Oestrinae larval stages. Twenty-six animals (14.1%; CI 95 9.44-20.02%) were infested by the roe deer nasal bot fly (Cephenemyia stimulator) with a mean intensity of 35.2 (SD 49.71) larvae/infested animal,and eighteen (9.8%; CI 95 5.90-15.02%) roe deer harboured the sheep bot fly (O. ovis), with a mean intensity of 2.0 (SD 1.33) larvae/infested animal. No mixed infestations by both Oestrinae were found in a single animal. All larval instars (L1, L2 and L3) of both species were identified. Most C. stimulator specimens were located at the nasal turbinates, and a small percentage (3.2%) at the pharynx; however, all O. ovislarvae were found at the nasal turbinates. Since O. ovis is highly prevalent in sheep and goats from Central Spain, the high sympatry between roe deer populations and small ruminant flocks in the studied area may have increased the risk of cross-infection. Moreover, the finding of mature third stage larvae of O. ovis suggests that this species can complete its life cycle in roe deer. Therefore, monitoring bot flies in sheep and goat flocks as well as in sympatric wild ruminants is strongly recommended for achieving an optimum control of nasal myiasis.
Effects of Crocin and Azithromycin and their co-administration on experimental model of sciatic nerve injury in rats
Authors: Abbaszadeh Mohammad Ebrahim , Pourheydar Bagher , Farjah Gholamhossein 
Published: February 2024

Abstract
Background: Although peripheral nerve injury is not life-threatening, it causes significant disability. Following these damages, ischemia and inflammatory processes occur, resulting in neurological dysfunction. Several medications have been explored in order to alleviate the symptoms of peripheral nerve injury. This study aimed to investigate how crocin and azithromycin affected sciatic nerve crush injuries in rats.
Methods: Five groups were established using 35 adult male rats: Control, Lesion, Azithromycin (AZ), Crocin (CR), and AZ+CR. Except for the control group, sciatic nerve injury was surgically induced in every other group. For seven days, azithromycin and crocin were administered. Following the completion of biochemical and behavioral evaluations, sections of sciatic nerve were stained in preparation for immunohistochemical and histological analysis.
Results: The healing process of sciatic nerve injury was expedited in all experiments by both azithromycin and crocin. However, the efficacy of crocin treatment was more pronounced in comparison to that of azithromycin. Crocin was found to be less efficacious than combination therapy involving AZ and CR, as determined by SFI, hot plate, and immunohistochemical analyses. In the remaining evaluations, however, no significant difference existed between the AZ+CR and CR groups.
Conclusion: The recovery process of sciatic nerve injury in rats was enhanced by both crocin and azithromycin; however, the effect of crocin treatment was stronger in the animals. In comparison to the crocin group, combination therapy with azithromycin and crocin did not produce a significant difference in the majority of aspects.
Data Fusion for Travel Analysis: Linking Travel Survey and Mobile Device Location Data
Authors: Zhao Guangchen , Al-Khasawneh Mohammad B. , Tuoto Tiziana , Cirillo Cinzia 
Published: February 2024

Abstract
Travel surveys typically collect detailed information about demographics and travel behavior of households and persons; but their sample sizes are often limited, and trip information is usually limited to a single day. In contrast, Mobile Device Location Data (MDLD) provides extensive and accurate trip records spanning multiple days for each person from a much larger sample, while demographic information for the individuals are always lacking due to anonymization. This study constructs data panels combining high-precision, long-term trip records from MDLD with detailed demographic information from a regional travel survey (RTS). Two probabilistic record linkage algorithms are employed to identify individuals with similar travel behaviors between RTS and MDLD datasets. The data panels constructed by the linkage algorithm captured not only peak-hour commutes but also off-peak travel and non-home-related trips, shedding light on previously underreported travel behaviors and offering a more holistic view of individuals' travel patterns. This comprehensive dataset also exhibits comparable demographic characteristics to the original RTS, showing that such data panel is a reasonable representation of the entire population. The integration of diverse datasets holds promise for revolutionizing travel behavior analysis and shaping the future of transportation planning in the era of mobile technology and big data.
Computational Discovery of Potential Drug Candidates from Phytochemicals of Withania somnifera and Saraca asoca Targeting Ebola and Marburg Viruses Infection
Authors: Ibrahim Munir , Detroja Asmita , Bhimani Avani , Bhatt Tirth Chetankumar , Bishoyi Ashok Kumar , Sanghvi Gaurav 
Published: February 2024

Abstract
Ebola and Marburg viruses are extremely lethal and cause hemorrhagic fever, with deaths from cases exceeding 90%. Currently, just a few licensed drugs for these diseases. This necessitates extensive research on natural compounds having putative therapeutic effects, particularly phytochemicals derived from medicinal plants. In this study, the molecular properties of six Withania somnifera and six Saraca asoca phytochemicals were analyzed. The aim was to assess their potential to bind and possibly inhibit the VP24 protein (vital for the viral replication) of both Ebola and Marburg viruses using computational approaches. The drug-likeness properties of the phytochemicals were determined using a Mol soft server, Further Prediction of pharmacokinetics was studied using a ProTox web server and pKCSN server, Molecular docking studies were carried out using PyRx software. The Insilico analysis revealed Withaferin A, Withanolide D, Withanolide F phytochemicals of Withania somnifera and Catechin, Epicatechin, and Isolariciresinol of Saraca asoca to have high binding affinity with both VP24 Proteins of Ebola and Marburg viruses, this suggests their potential to bind with the VP24 protein, disrupt its normal function, and consequently impede viral replication. These findings strongly imply that these phytoconstituents could possess antiviral properties. However, to validate and establish the antiviral potential of these phytochemicals, further investigations are imperative. Methods such as molecular dynamics simulations, in-vivo and in-vitro studies should be conducted. Upon successful validation, these phytochemicals could emerge as viable candidates for the development of drugs aimed at treating Ebola and Marburg diseases.
Quasi-ductile fracture behavior of glubam due to transverse fiber distribution
Authors: Jiang Haolei , Liu Wen 
Published: February 2024

Abstract
The cracking of fibrous composites is inevitable, and the cracking mode is depended on its fiber distribution. In this study, bamboo fibrous composites are selected to investigate the effect of fiber distribution on crack propagation. Glued-laminated bamboo (Glubam) is a bi-directional bamboo fibrous composites, usually used as a board member, its vertical thickness (V direction) is about 28 mm, and with the longitudinal fiber layers (L direction) to transverse fiber layers (T direction) setting a 4:1. Considering that there are fewer transverse fibers in glubam, it is more prone to cracking under transverse load, this study researches the mode-I fracture characteristics of glubam in the TV direction. The three-point bending (3-p-b) fracture test of glubam specimens with single-edge notches (SEN) was carried out in this study. The deformation curves show that the specimens still have the load-carrying capacity after reaching the maximum load, and the load shows a trend of step-like decrease, exhibiting a quasi-ductile fracture behavior. Overall, the fracture process can be divided into four stages, including linear, softening, quasi-ductile, and failure stages. In this study, the tensile strength ft and fracture toughness KIC of glubam in the softening and quasi-ductile stages are calculated using nonlinear elastic fracture mechanics (Non-LEFM) method, and the prefabricated crack length a0 is modified according to the location of the transverse fibers. The deviations of the fracture parameters in the two stages are within 10%, which indicates that the modification of the prefabricated crack length is correct and indirectly demonstrates the correlation between the fracture parameters of the quasi-ductile stage and the transverse fiber position. On the other hand, quasi-ductile fractures exist in other materials and structures, and they all have staggered structures. This staggered structure makes the crack in the form of semi-stable propagation, while the load decreases in a step-like manner.
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
Authors: Gu Nina , Yan Jin , Tang Wei , Zhang Zhaosi , Wang Lin , Li Zhao , Wang Yingwen , Zhu Yajun , Tang Shuang , Zhong Jianjun , Cheng Chongjie , Sun Xiaochuan , Huang Zhijian 
Published: February 2024

Abstract
Background
The gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut microbiota is associated with neurological impairment in TBI patients. Our previous study found that TBI results in a decrease in the abundance of Prevotella copri (P. copri). Manipulation of the gut microbiota is a promising intervention strategy, but less is known about the potential role of P. copri transplantation in TBI.
Methods
In this study, a controlled cortical impact (CCI) model was used to induce traumatic brain injury (TBI) in adult male C57BL/6 mice. Subsequently, P. copri was transplanted by intragastric gavage for 7 consecutive days. To investigate the effect of the GUO-PI3K/Akt pathway in P. copri transplantation therapy, guanosine (GUO) was administered 2 h after TBI for 7 consecutive days, and PI3K inhibitor (LY294002) was administered 30 min before TBI. Various techniques were used to assess the effects of these interventions, including quantitative PCR, neurological behavior tests, metabolite analysis, ELISA, Western blot analysis, immunofluorescence, Evans blue assays, transmission electron microscopy, FITC-dextran permeability assay, gastrointestinal transit assessment, and 16S rDNA sequencing.
Results
P. copri abundance was significantly reduced after traumatic brain injury (TBI). P. copri transplantation alleviated motor and cognitive deficits tested by the NSS, Morris water maze, and open field test. P. copri transplantation attenuated oxidative stress and blood-brain barrier damage and reduced neuronal apoptosis after TBI. In addition, P. copri transplantation resulted in the reshaping of the intestinal flora, improved gastrointestinal motility and intestinal wall permeability. Metabolomics and ELISA analysis revealed a significant increase in GUO levels in feces, serum and injured brain after P. copri transplantation. Furthermore, the expression of p-PI3K and p-Akt was found to be increased after P. copri transplantation and GUO treatment. Notably, LY294002 treatment attenuated the observed improvements.
Conclusions
We demonstrate for the first time that P. copri transplantation can improve GI functions and alter gut microbiota dysbiosis after TBI. Additionally, P. copri transplantation can ameliorate neurological deficits, possibly via the GUO-PI3K/Akt signaling pathway after TBI.
Monitoring Values of Routine Echocardiography and Two-dimensional Speckle Tracking Imaging in Cardiotoxicity Caused by Treatment of Breast Carcinoma with Anthracyclines
Authors: Song Wenjuan , Ma Xuejuan , Sun Yue , Liu Liping , Gu Ying , Zhao Yue , Ye Yujia , Wang Yu 
Published: February 2024

Abstract

Objective
This research was conducted to investigate the monitoring values of routine echocardiography (ECG) and two-dimensional speckle tracking imaging (2D-STI) in cardiotoxicity caused by the treatment of breast carcinoma with anthracyclines (ANTH).
Methods
100 patients with breast carcinoma were selected and enrolled into normal group (n = 53 cases) and abnormal group (47 cases) according to whether ECG was abnormal. Routine ECG and 2D-STI were employed for the detection, ECG- and 2D-STI-related parameters were compared, receiver operating characteristic (ROC) curves were drawn, and the clinical application values of monitoring methods for two groups were assessed.
Results
Before chemotherapy, no remarkable statistical difference was detected in routine ECG and 2D-STI parameters between normal and abnormal groups (P > 0.05). After 6 cycles, E/V value of abnormal group was inferior to that of normal group ((0.93 ± 0.16) vs (1.33 ± 0.23). Besides, longitudinal peak strain (SRI) values of rear wall, front spacer, and rear spacer in abnormal group were inferior to those in normal group (P < 0.05). Routine ECG combined with 2D-STI had the best predictive effect followed by 2D-STI and routine ECG.
Conclusion
To sum up, 2D-STI was a new method for assessing myocardial lesions and possessed significant early clinical monitoring values in cardiotoxicity caused by chemotherapy after the treatment of breast carcinoma with ANTH. It had higher clinical application values than routine ECG.
The Discovery of a Contact-Binary Satellite of the Asteroid (152830) Dinkinesh by the Lucy Mission
Authors: Levison Harold 
Published: February 2024

Abstract

On November 1, 2023, Lucy passed within 431 km of the smallest Main Belt asteroid yet to be encountered by a spacecraft, (152830) Dinkinesh. This target was a late addition to the Lucy mission \cite{Levison+2021} and was intended primarily as an in-flight test of the Terminal Tracking system, an autonomous range-finding and tracking system that is a critical component of Lucy’s operations \citep{Olkin+2021}. Data obtained by Lucy’s instruments during the encounter revealed Dinkinesh, which has an effective diameter of only ~720 m, to be an unexpectedly complex system. Of particular note is the presence of a substantial equatorial ridge and a longitudinal trough, and the discovery of the first confirmed contact binary satellite, now named (152830) Dinkinesh I Selam. Selam consists of two near-equal sized lobes with diameters of ~210 m and ~230 m. It orbits Dinkinesh at a distance of ~3.1 km with an orbital period of about 53 hr, and is tidally locked. Dinkinesh's ridge and trough are likely the result of mass failure resulting from YORP torques, and the reaccretion of material. This event is probably linked to the formation of Selam.
Synergy between plant essential oils and Pseudomonas isolate secondary metabolites against the two-spotted spider mite Tetranychus urticae Koch
Authors: Basaid Khadija , Chebli Bouchra , Bouharroud Rachid , Elaini Rachid , Furze James Nicholas , alaoui Ilyass Filali , Kaoui Soukaina , Zaidouni Safaa , Paulitz Timothy , Mayad El Hassan 
Published: February 2024

Abstract

In the pursuit of developing effective bio-acaricidal agents, the toxicity by residual contact and repellency of the essential oils (EOs) ofOriganum compactum,Mentha piperitaandArtemisia herba-albaand their mixtures against adults ofTetranychus urticaewas investigated. The oils demonstrated repellency and toxicity to mites based on dose. Combinations of the EOs in binary and ternary forms had antagonistic and additive effects on the mite's toxicity and repellency, with the exception of combinedO. compactumandM. piperitaEOs that displayed a synergistic acaricidal relationship. The chemical composition of the oils was identified via GC/MS analysis; major constituents were thymol (49%) inO. compactum, linalool (45.81%) inM. piperitaand camphor (25.08%) inA. herba-alba. Further, we evaluated the acaricidal activity of secondary metabolites produced byPseudomonasspecies using cell-free supernatants, and reported on the mode of entry ofPseudomonassupernatants into adult mites. The bioactive acaricidal compounds were most effective (57.6 to 96.1% mortality) when the entire integument ofT. urticaewas contacted compared to the ventral side only (15.3 to 80.7%). The toxicity of the most active bacterial supernatant was investigated at 1/2, 1/4 and 1/8 dilutions in combination with the EOs. The combinations synergistically killed the mite. Lethal effects were seen 72h after exposure. Bio-acaricidal formulations may take use of synergistic combinations to manage the two-spotted spider mite.
Prediction of turbulent flows behind cylinder arrays via Echo State Networks
Authors: Ghazijahani Mohammad Sharifi , Cierpka Christian 
Published: February 2024

Abstract

This study aims at the prediction of the turbulent flow behind cylinder arrays by the application of Echo State Networks (ESN). Three different arrangements of arrays of seven cylinders are chosen for the current study. Three different wake flow regimes are represented by these arrays: single bluff body flow, transient flow, and co-shedding flow, which allows inherently similar, yet very different, turbulent flows to be studied. The data is reduced by Proper Orthogonal Decomposition (POD), and then the Time Coefficients of the POD Modes (TCPM) are predicted by the ESN. The ESN is optimized with respect to its three main hyperparameters, Input Scaling (INS), Spectral Radius (SR), and Leaking Rate (LR), in order to produce the best predictions in terms of Weighted Prediction Score (WPS). In general, the ESN is capable of imitating the complex dynamics of turbulent flows even for long periods. Furthermore, the mutual interdependencies of the TCPM are well preserved. However, the ESN’s performance in different hyperparameters depends on the flow characteristics. Generally, as flow dynamics become faster and more intermittent, larger LR and INS values make better predictions, whereas less clear trends in SR values tend to emerge.