bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjunctive Antimicrobial Therapy of Periodontitis: Long‐Term Effects on Disease Progression and Oral Colonization
Authors: Ehmke Benjamin , Moter Annette , Beikler Thomas , Milian Edwin , Flemmig Thomas F. 
Published: May 2005

Background: This study assessed the long‐term effects of adjunctive antimicrobial therapy on periodontal disease progression and oral colonization.Methods: Patients with previously untreated chronic periodontitis and subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to subgingival scaling without (control group) or with systemic amoxicillin plus metronidazole and CHX irrigation (test group). Relative attachment levels were determined and subgingival and mucosal plaque samples were taken at baseline, at 10 days (plaque only) and at 3, 6, 9, 12, 18, and 24 months following initial therapy. During maintenance therapy, patients received supragingival debridement only.Results: After 24 months, the 18 test group patients showed at sites with initial probing depths (PD) ≥7 mm a significantly (P <0.05) higher frequency of 2 mm or more attachment gain (37.3% ± 4.6%) and lower frequency of attachment loss (7.2% ± 3.1%) compared to the 17 controls (8.2% ± 3.9% and 19.1% ± 13.1%, respectively). Compared to controls, the intraoral prevalence of A. actinomycetemcomitans (up to 18 months) and P. gingivalis (up to 3 months) decreased and that of Eikenella corrodens (at 10 days) increased in test patients (P <0.05). In both treatment groups, the detection frequency of Tannerella forsythensis decreased transiently, while an overall increase was recorded for Treponema ssp.Conclusions: Over the 24‐month period, a single course of the administered adjunctive antimicrobial therapy led to a relative risk reduction of 62% for attachment loss at deep sites. However, with the exception of A. actinomycetemcomitans, it failed to induce long‐term changes in the prevalence profiles of oral colonization. J Periodontol 2005;76:749‐759.
Analysis of Interleukin‐Activated Human Gingival Fibroblasts: Modulation of Chemokine Responses by Female Hormones
Authors: Lapp Carol A. , Lapp David F. 
Published: May 2005

Background: The female sex hormones are known to affect the response of numerous tissues to an immune challenge. Because such hormones normally fluctuate during puberty, pregnancy, and the menstrual cycle, more information about the hormonal modulation of such responses in the oral cavity is needed. Gingival fibroblasts (GF), major components of the oral tissues, are potentially sources for inflammatory mediators.Methods: Macroarrays specific for cytokines and related proteins were used to examine the regulation of gene expression in GF under serum‐free, resting conditions, after immune challenge with interleukin‐1β (IL‐1β), and in the presence of IL‐1β plus a progestin, ±17β‐estradiol. Additional studies used enzymelinked immunosorbent assays (ELISAs) to test for secreted chemokines after the same treatments.Results: Of the 392 genes on the macroarray, 66 were up‐ or downregulated at least 2‐fold relative to the unstimulated control in an average of six different sub‐lines. Chemokines represented the largest group (18%) of these regulated genes. Numerous genes whose expression was upregulated by IL‐1β were modulated downward by IL‐1β plus progestin, ±17β‐estradiol. Measurements of the secretion of IL‐8, a CXC chemokine, and MCP‐1, a CC chemokine, confirmed the inhibitory effect of a progestin on these genes.Conclusions: Gingival fibroblasts are active participants in the immune response in the oral cavity, and may potentially produce many chemokine signals after exposure to IL‐1β. GF can attract neutrophils, monocytes, eosinophils, and fibroblasts to the area of injury, and aid in the wound repair process. The concentration of female sex hormones, especially progestin, may significantly affect these signaling systems. J Periodontol 2005;76:803‐812.
Periodontal Status in Two Siblings With Severe Congenital Neutropenia: Diagnosis and Mutational Analysis of the Cases
Authors: Hakki Sema S. , Aprikyan Andrew A.G. , Yildirim Sibel , Aydinbelge Mustafa , Gokalp Alparslan , Ucar Canan , Guran Sefik , Koseoglu Vedat , Ataoglu Tamer , Somerman Martha J. 
Published: May 2005

Background: Severe congenital neutropenia (SCN), also known as Kostmann syndrome, was originally reported as an autosomal recessive disease of neutrophil production. The disease is characterized by a maturation arrest of neutrophil precursors at the promyelocytic stage of differentiation and by extremely low levels of mature neutrophils in peripheral blood.Methods: A 6‐year‐old male presented with a complaint of gingival swelling and bleeding, and swelling at the left side of his face. Upon clinical examination, severe inflammation of all gingival tissues was apparent, and a periapical abscess with mobility was noted on the left mandibular second molar. Medical and dental histories revealed numerous recurrent bacterial infections associated with oral and non‐oral tissues. His medical history with recurrent infections led us to evaluate his 3‐year‐old sister to determine the status of her oral health. Inflammation of her oral tissues and recurrent bacterial infections were apparent. Their consanguineous parents were in good health. To assist in identifying possible systemic diseases underlying the inflammatory situation in the siblings, consultations were requested from the Pediatric Hematology Department at Selcuk University and Pediatric Oncology Department at Gulhane Military Medical Academy.Results: Based on absolute neutrophil count (≤200/mm3) and bone marrow aspiration findings consistent with early maturation arrest in myelopoiesis, the cases were diagnosed as SCN. No chromosomal abnormality was detected upon cytogenetic examination. Sequencing analysis also revealed no mutation in the neutrophil elastase or growth factor independent‐1 (GFI‐1) genes in these patients. Severe periodontal disease, attachment loss, and mobility for over 50% of the deciduous teeth were noted. Within 6 months, the male sibling lost all of his deciduous teeth due to periapical and periodontal infections. His sister presented with tooth mobility for all mandibular incisors. Monthly visits, including scaling, polishing, and 0.2% chlorhexidine digluconate irrigation were performed to support their oral hygiene and to avoid recurrent oral infections. We have been able to stabilize these patients' periodontal conditions during a 2‐year follow‐up period.Conclusion: This case report emphasizes the role of periodontists and pediatric dentists in the diagnosis of diseases linked with neutrophil and other systemic disorders and highlights the need to optimize the health of oral tissues with regular appointments. J Periodontol 2005;76:837‐844.
Age progression along the Society hotspot chain (French Polynesia) based on new unspiked K-Ar ages
Authors: Guillou Hervé , Maury René C. , Blais Sylvain , Cotten Joseph , Legendre Christelle , Guille Gérard , Caroff Martial 
Published: May 2005

Abstract
New K-Ar dates of volcanic rocks from five of the nine islands of the Society Archipelago (Moorea, Huahine, Raiatea, Bora Bora and Maupiti), confirm a Pacific plate velocity of around 11 cm/a during the last 4.3 m.y. These new data allow us to analyse the age-distance relationship along the chain and to evaluate possible temporal variations in the activity of the Society hotspot. A clear increase of ages is observed along the linear chain away from the present Society hotspot location. The time-space relationship between Taiarapu, Tahiti-Nui and Moorea can be explained by a simple hotspot model. Nevertheless, the simple fixed hotspot model assuming constant Pacific plate velocity may need adjustments to fully explain the age progression along the Archipelago. The slight departures from a linear age distribution can be explained by changes in Pacific plate motion which occurred at 5 and 3 Ma. In addition, the contemporaneous magmatic activities in the pairs Bora-Bora/Tahaa, Raiatea/Huahine, Maiao/Moorea require additional lithospheric control on magma transport. Combined with the hotspot activity, lithospheric loading may have produced extension and triggered volcanism along already existing fractures linking paired islands.
The most likely model for the Society chain, proposed by McNutt [1998], involves a plume originating from a wide deep thermally anomalous zone (the Pacific Superswell) as a rising diapir (hotspot of secondary type according to the classification of Courtillot et al. [2003]). It melted during ascent and ponded beneath the Pacific plate to form short linear island chains showing rather good age vs. distance correlations.
The Hospital coal basin (Massif Central, France): relay on the left-lateral strike-slip Argentat fault in relation to the Variscan postorogenic extension
Authors: Bellot Jean-Philippe , Roig Jean-Yves , Genna Antonin 
Published: May 2005

Abstract
Structural and microstructural analyses of the Argentat fault, combined with sedimentological and structural analyses of the associated Hospital basin allow us to discuss the tectonic control of coal basins by crustal-scale faults during the late Palaeozoic evolution of the Variscan lithosphere in the French Massif Central. The brittle Argentat fault zone consists of first- and second-order strike-slip faults, with dominant NNW-sinistral faults, NNE-dextral or sinistral faults and secondary ENE-dextral faults. Several experimental and theoretical models explain the observed fault patterns, like en echelon faults, A-type secondary faults, conjugate faults and Riedel shears. Strike-slip faulting is responsible for folding of the metamorphic formations characterized by N-S to NE-SW-trending axis. The regional-scale geometry of brittle faults and associated folds corresponds to a positive flower structure centered on the brittle Argentat fault, combined to a negative flower structure centered on the coal basin. Using tectonic inversion software, we show that these structures result from a left-lateral movement of the brittle Argentat fault in relation to a tectonic regime intermediate between extension and strike-slip, with a horizontal NE-SW to NNE-SSW-trending maximum stretching axis. Detailed map and cross-sections, and sedimentological interpretations of the late Stephanian Hospital basin show the occurrence of intra-basin syn-sedimentary strike-slip faults and progressive overlaying, indicating that sedimentation occurs during left-lateral strike-slip faulting and folding of basement along the Argentat fault. These data are consistent with a model of N-S to NE-SW-trending postorogenic extension proposed to account for the late Carboniferous evolution of the Variscan lithosphere. They also point out the complexity and the variety of structures developed along a regional brittle strike-slip fault zone and the necessity to take into account all the structures and the resulting geometry of the basement in order to better constrain the tectonic setting of intra-continental deposits.
Diachronism in the sedimentary cover around the Troodos ophiolitic massif (Cyprus)
Authors: Peybernès Bernard , Fondecave-Wallez Marie-José , Cugny Pierre 
Published: May 2005

Abstract
The detailed micropaleontologic study of the sedimentary series overlying the youngest ophiolitic basalts of the Troodos massif (Cyprus), confirms the late Campanian age of the top of the oldest terrigenous cover (Kannaviou Formation) topping these ophiolites themselves assigned to Cenomanian-Turonian. It also demonstrates for the first time the strong diachronism of the Lefkara Formation chalky limestones, unconformably overlying either the Kannaviou Fm. sandstones and clays, or the oceanic basalts. This diachronism over short distances and the on-lap of the Lefkara Fm. are revealed by varying stratigraphic gaps within the Paleocene-Miocene interval and are indicated by new age datings of the transgressive basal part of the Lefkara Fm. along six principal sections: late Thanetian (Zone P5) at the Pano Lefkara typelocality; early Ypresian (Sub-zone P6a) at Agia Anna; earliest Bartonian (Zone P13) at Kannaviou and Analiontas; early-middle Lutetian (Zones P10 to P11) at Kofinou; Langhian (Zone N8) at Choulou. Maastrichtian deposits are missing and Maastrichtian Globotruncanidae/Heterohelicidae only observed as individual reworked specimens within well-dated Tertiary levels. Finally, we discuss the influence of the Tertiary extensional brittle tectonics on this diachronism, the on-lap processes and the differential subsidences occurring after the late Cretaceous/? early-middle Paleocene folding (Laramian compression).
A record of the Jurassic/Cretaceous boundary climatic variation on the southern margin of the Tethys : clay minerals and palynofacies of the early Cretaceous Jebel Meloussi section (Central Tunisia, Sidi Kralif Formation)
Authors: Schnyder Johann , Gorin Georges , Soussi Mohamed , Baudin François , Deconinck Jean-François 
Published: May 2005

Abstract
In order to precise the paleogeographic extension of the climatic variation known at the Jurassic/Cretaceous boundary, the sedimentary organic matter (palynofacies and Rock-Eval) and the clay minerals content of Berriasian sediments of the Sidi Kralif Formation are studied on the Jebel Meloussi section, central Tunisia. Standard sedimentological and palynofacies analysis allow to reconstruct the bathymetric curve and the sequence stratigraphic scheme. Using existing biostratigraphy based on calpionellids and ammonite zonation, the sequence stratigraphic interpretation can be correlated with the established eustatic chart. Clay mineral assemblages are characterized by a shift in the kaolinite content, recorded at the end of the calpionellid zone B, at the early/middle Berriasian boundary, at a time of high long-term sea-level (MFS Be2, second order eustatic peak). A contemporary change in the clay mineral assemblages, interpreted as a climatic change, is known from the boreal area, and from the northern margin of the Tethys Sea. That change is also documented southerly in southern Morocco (Agadir area), on the Atlantic domain. A late Tithonian to early Berriasian dry and cooler phase is replaced by a middle to late Berriasian more humid phase, indicated by a general increase in kaolinite in the clay mineral assemblages. The trend from a dry climatic phase to a more humid one, recorded on the boreal domain and along the northern margin of the Tethys is also recorded in lower paleolatitudes of Tunisia, on the southern margin of the Tethys, in better dated outcrops than the ones of Morocco. The results obtained in Tunisia show that the beginning of the climatic change was precisely synchronous on both margins, and occurred within the same long-term high sea-level context.
Quantitative analysis of the bioassociations and characterization of the system tracts and paleogeographic zones in the Cenomanian and Turonian series of the Aurès Mountains and eastern Tell (Algeria)
Authors: Herkat Missoum 
Published: May 2005

Abstract
The aim of this study of Aurès and Bibans (Tell) Cenomanian and Turonian series is the application of a sedimentological analysis in order to reconstruct the relationships between biocenoses, environments, systems tracts and depositional sequences. A quantitative approach has been developed including the study of variations of organism’s abundance in the sequences and in the palaeogeographic zones and the multivariate data analysis applied to the characterisation of biocenoses. These methods provide, compared to the results obtained by the more classical facies study, new informations about the evolution of the various organisms in the system tracts and their relations with the different palaeogeographic zones.
The increasing multiplicity of the species concepts
Authors: Génermont Jean 
Published: May 2005

Abstract
In 1980, Henri Tintant advocated the usefulness of the biological species concept in paleontology. At this time, this concept was still accepted by many neontologists, but it was already rather severely criticized by some others. In fact, a lot of new concepts appeared in the course of the following two decades. While a few ones are mere adjustments of the biological concept, for instance taking in account ecological criteria, in such a way that it could be applied to clonal organisms, some others, which were developed in connexion with the cladistic theory of taxonomy, are truly new from a conceptual point of view. The diagnosable version of the phylogenetic species concept is somewhat reminiscent of Simpson’s evolutionary species concept, since it accepts phyletic speciation as well as survival of the stem species after a cladogenetic event. One of its more criticizable features, from a cladistic point of view, is that the species are not necessarilly monophyletic. On another hand, according to the monophyly version of the phylogenetic species concept, species are recognized rather subjectively as monophyletic taxa revealed by some previous cladistic analysis dealing with operational taxonomic units.
A consensus on the definition of species cannot be expected, since all concepts related to the biological one are founded on population grouping on the basis of potentially identical evolutionary fates, while those which are related to cladistic taxonomy are exclusively concerned with historical features.
Age-Related Risk of Serious Fall Events and Opioid Analgesic Use
Authors: Hopkins Ria E. , Bharat Chrianna , Buizen Luke , Close Jacqueline , Ivers Rebecca , Draper Brian , Pearson Sallie-Anne , Degenhardt Louisa , Gisev Natasa 
Published: February 2024

ImportanceOpioid analgesics may be associated with increased risk of falls, particularly among older adults.ObjectiveTo quantify the age-related risk of serious fall events among adults prescribed opioids by opioid exposure, time from initiation, and daily dose.Design, Setting, and ParticipantsThis population-based cohort study conducted in New South Wales, Australia, used data linking national pharmaceutical claims to national and state datasets, including information on sociodemographic characteristics, clinical characteristics, medicines use, health services utilization, and mortality (POPPY II study). It included adults (18 years or older) who initiated prescription opioid treatment, which was defined as no prior dispensing during the preceding 365 days, between January 1, 2005, and December 31, 2018. Data were analyzed from February to June 2023.ExposureTime-dependent periods of opioid exposure were evaluated from dispensing records.Main Outcome and MeasuresSerious fall events identified from emergency department, hospitalization, and mortality records. Negative binomial models were used to assess associations between time-dependent opioid exposure (overall, by time from initiation, and by dose), age, and risk of fall events. Models were adjusted for known fall risk factors, including other fall risk–increasing drugs, frailty risk, and prior serious fall events.ResultsThe cohort comprised 3 212 369 individuals who initiated prescription opioid treatment (1 702 332 women [53%]; median [IQR] age at initiation, 49 [32-65] years). Overall, 506 573 serious fall events were identified, including 5210 fatal falls. During exposure to opioids, the risk of serious fall events was elevated among all age groups; compared with the group aged 18 to 44 years, this risk was highest among those 85 years or older (adjusted incident rate ratio, 6.35; 95% CI, 6.20-6.51). Across all age groups, the first 28 days following opioid initiation was a time of increased serious fall risk; this risk increased with age. Among individuals aged 18 to 84 years, associations were identified between higher daily opioid doses and serious fall events.Conclusions and RelevanceThe results of this cohort study suggest that prescription opioids were associated with increased risk of serious fall events among adults of all ages, with individuals 85 years or older at greatest risk. These risks should be considered when prescribing opioids, particularly for individuals with preexisting risk factors or when opioids are prescribed at higher doses. Targeted falls prevention efforts may be most effective within the first month following opioid initiation.
Assessing trade‐offs in developing a landscape‐scale nest monitoring programme for a threatened shorebird
Authors: Ellis Kristen S. , Anteau Michael J. , MacDonald Garrett J. , Ring Megan M. , Sherfy Mark H. , Swift Rose J. , Toy Dustin L. 
Published: February 2024

Abstract

Effective monitoring of wildlife species requires thorough planning and development of survey programmes that can address management and conservation objectives. Decisions about monitoring programmes include where to survey, survey design and how much effort to allocate at survey sites are typically predicated on limited budgets and available resources. When the scope of inference requires monitoring on a broad spatial scale, predictions of habitat distribution or suitability may be useful for identifying potential survey sites.

We focused on a threatened but widely distributed shorebird, the piping plover (Charadrius melodus), which is actively monitored across some, but not all of its range. Our objective was to use piping plover habitat distribution maps, which vary annually, to assess the effectiveness of multiple monitoring programme scenarios and their associated costs.

In the breeding range, efforts to improve productivity for species of conservation concern often focus on improving probabilities of nest survival. Consequently, collecting adequate nesting data is crucial for obtaining accurate and precise estimates of nest survival and for evaluating the effectiveness of management actions. By simulating the nest monitoring process, we evaluated how much area, where and how often to survey each site when estimating nest survival and detecting effects of potential management actions.

As expected, precision increased and bias decreased around nest survival estimates with greater survey coverage and nest visit frequency. We also identified monitoring programmes with negative net values where survey costs outweighed statistical benefits.

Although we applied our simulation framework to evaluate nest monitoring designs for piping plovers, it could be extended to assess whether different monitoring programmes can detect changes in the distribution of other species or occupancy of habitats over time.