bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
Authors: Wang Ying‑Chuan , Tsai Chih-Hsuan , Wang Yung-Chih , Yen Li-Chen , Chang Yao-Wen , Sun Jun-Ren , Lin Te-Yu , Chiu Chun-Hsiang , Chao Yu-Chan , Chang Feng-Yee 
Published: December 2023

Abstract
Purpose
The aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may initiate cytokine cascades and correlate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with their serum cytokine profiles.

Methods
Recombinant baculoviruses displaying SARS-CoV-2 spike or nucleocapsid protein were constructed and transfected into A549 cells and THP-1-derived macrophages, to determine which protein initiate cytokine release. SARS-CoV-2-specific antibody titers and cytokine profiles of patients with COVID-19 were determined, and the results were associated with their clinical characteristics, such as development of pneumonia or length of hospital stay.

Results
The SARS-CoV-2 nucleocapsid protein, rather than the spike protein, triggers lung epithelial A549 cells to express IP-10, RANTES, IL-16, MIP-1α, basic FGF, eotaxin, IL-15, PDGF-BB, TRAIL, VEGF-A, and IL-5. Additionally, serum CTACK, basic FGF, GRO-α, IL-1α, IL-1RA, IL-2Rα, IL-9, IL-15, IL-16, IL-18, IP-10, M-CSF, MIF, MIG, RANTES, SCGF-β, SDF-1α, TNF-α, TNF-β, VEGF, PDGF-BB, TRAIL, β-NGF, eotaxin, GM-CSF, IFN-α2, INF-γ, and MCP-1 levels were considerably increased in patients with COVID-19. Among them, patients with pneumonia had higher serum IP-10 and M-CSF levels than patients without. Patients requiring less than 3 weeks to show negative COVID-19 tests after contracting COVID-19 had higher serum IP-10 levels than the remaining patients.

Conclusion
Our study revealed that nucleocapsid protein, lung epithelial cells, and IP-10 may be potential targets for the development of new strategies to prevent, or control, severe COVID-19.
Extensive Study of Modern Approaches Used in Identifying the Buckingham Potential
Authors: Surulere S. A. , Shatalov M. Y. , Olayiwola F. E. 
Published: December 2023

AbstractThis paper presents two mathematical approaches of estimating unknown parameters of the Buckingham potential. Two functional forms of the potential was investigated owing to the complexities and difficulties arising from the original Buckingham potential. These complexities are due to the combination of both powers and an exponent in mathematical representation of the potential. Hence, we decided to consider approximating the parameters of the simpler form, widely known as the modified Buckingham potential. The method of least squares (differential and integral methods) were used to estimate the potential parameters and the calculation of the optimized values of the constructed goal function were included in the paper. The calculated estimates showed reasonable agreement with experimental datasets of copper atoms over a large vicinity of the interatomic potential distance. This conclusion was reached through the graphical analysis of potential energy curves and through the error between the respective curves. Optimized goal function values were used to compare the efficiency of the methods.
Information geometry of dynamics on graphs and hypergraphs
Authors: Kobayashi Tetsuya J. , Loutchko Dimitri , Kamimura Atsushi , Horiguchi Shuhei A. , Sughiyama Yuki 
Published: December 2023

AbstractWe introduce a new information-geometric structure associated with the dynamics on discrete objects such as graphs and hypergraphs. The presented setup consists of two dually flat structures built on the vertex and edge spaces, respectively. The former is the conventional duality between density and potential, e.g., the probability density and its logarithmic form induced by a convex thermodynamic function. The latter is the duality between flux and force induced by a convex and symmetric dissipation function, which drives the dynamics of the density. These two are connected topologically by the homological algebraic relation induced by the underlying discrete objects. The generalized gradient flow in this doubly dual flat structure is an extension of the gradient flows on Riemannian manifolds, which include Markov jump processes and nonlinear chemical reaction dynamics as well as the natural gradient. The information-geometric projections on this doubly dual flat structure lead to information-geometric extensions of the Helmholtz–Hodge decomposition and the Otto structure in $$L^{2}$$

L
2

-Wasserstein geometry. The structure can be extended to non-gradient nonequilibrium flows, from which we also obtain the induced dually flat structure on cycle spaces. This abstract but general framework can broaden the applicability of information geometry to various problems of linear and nonlinear dynamics.
A true crime story: The role of space, time, and identity in narrating criminal authority
Authors: Rossi Norma 
Published: December 2023

AbstractThis article presents a theoretical and methodological argument for employing a narrative-based approach to explore criminal organisations’ (COs) claims to political authority, accompanied by an empirical example. International Relations scholarship is increasingly interested in the role narratives play in political meaning-making processes, with violent non-state actors (VNSAs) beginning to occupy a central space in such investigations. This work has contributed important insights into how VNSAs, such as terrorists and insurgents, mobilise narratives to challenge state authority. However, this literature still needs to take stock of groups that do not directly challenge the state but rather live within it. Drawing on Mikhail Bakhtin’s literary theory and using the Sicilian Mafia as a case study, I show that COs exercise and construct their narratives of political authority by reappropriating the state’s key constitutive narratives of space, time, and identity. By reflecting the same form of (statist) political imagination via alternative spatial, temporal, and identity configurations, these groups simultaneously reject and reproduce modern articulations of political authority in their spatio-temporal and identity dimensions.
Replacing the standard bearer: Theorising leadership transition in insurgencies
Authors: Youngman Mark , Moore Cerwyn 
Published: December 2023

AbstractThe transition from one leader to the next represents a critical moment in the life cycle of insurgencies: it is a period of heightened uncertainty and vulnerability when roles and relationships are in flux. However, remarkably little scholarly attention has been paid to understanding this process. Building our case around the insurgency in Russia’s North Caucasus, we address this gap by developing a typology of key tasks that new leaders must perform in order to navigate the transition period. We argue that, within insurgencies that are weakly institutionalised, leadership can most usefully be conceived of as a negotiated relationship in which both leaders and followers have agency. Successful performance of these tasks helps ensure the maintenance of this relationship and, through this, movement continuity. Therefore, this paper contributes to both the empirical literature on insurgency and our understanding of leadership and transition within rebel movements.
Granting Immigrants the Right to Vote in National Elections: Empirical Evidence from Swedish Administrative Data
Authors: Aggeborn Linuz , Andersson Henrik , Dehdari Sirus H. , Lindgren Karl-Oskar 
Published: December 2023

AbstractFaced with rising levels of cross-border migration, many countries have extended local voting rights to non-citizen residents. However, empirical evidence indicates that voter turnout among non-naturalized immigrants is lower when compared to citizens. This raises the question of how to explain this difference. A common answer is that the low turnout rates of non-citizen residents are primarily due to the socio-economic composition of this group and the challenges involved in adapting to a new political system. An alternative but less discussed possibility is that the low turnout concerns the nature of the elections. Hence, we examine whether the turnout of non-citizens is hampered because they are only allowed to partake in local elections. Based on a regression discontinuity design (RDD) using Swedish administrative data, we find that turnout could increase by 10–20 percentage points if the voting rights of non-citizens were extended to the national level.
Distant metastasis at the time of presentation of head and neck squamous cell carcinoma: a retrospective chart review from a tertiary cancer care centre
Authors: Majitha CS , Nayak Dipak Ranjan , Shetty Shama , Devaraja K , Basheer Juhi Irfana 
Published: December 2023

AbstractObjectiveTo evaluate the rates and patterns of distant metastasis in head and neck SCC at the time of presentation and to study the association between distant metastasis with pre-treatment, clinical, and pathological predictors of outcomes.MethodThis is a retrospective study conducted in a tertiary care hospital. All patients with primary head and neck squamous cell carcinoma that had been evaluated at our institute between October 2018 and December 2020 were included in the study. Various clinical data were analysed and pattern of metastasis was studied.ResultTen per cent (50 cases) of 501 studied patients had distant metastasis. The most common site of distant metastasis was lung. The rate of distant metastasis was high in patients with poorly differentiated cancers. By Kaplan–Meier analysis, the median survival duration after diagnosis of metastasis was four months.ConclusionThe rate of distant metastasis was 10 per cent in the study. Patients with poorly differentiated tumours, locally advanced primary lesions, higher nodal stage, particularly with extra nodal extension, and hypopharyngeal primary, tend to exhibit increased risk for distant metastasis at the time of presentation.
The Entangled Nature of Work: Histories of Humans and Nonhuman Labor
Authors: Fleischman Thomas 
Published: December 2023

AbstractA survey of recent works of labor and environment reveal the centrality of hybridity to analyses of human and nonhuman natures. These are most apparent in analyses of labor, technology, and nature. While ways of knowing nature amongst the powerful have been oriented toward the ever-greater domination of workers and nonhuman nature, interspecies entanglements and solidarity erupt through the marginal, overlooked spaces. Taken together, the books included in this review suggest a way toward finding alternative, more just futures for living alongside nonhuman nature.
A transformable wheel-spoke-paddle hybrid amphibious robot
Authors: Ge Yikai , Gao Feng , Chen Weixing 
Published: December 2023

AbstractThe intricate water-land intermingled nature of wild environments necessitates robots to exhibit multimodal cross-domain mobility capabilities. This paper introduces a novel wheel-spoke-paddle hybrid amphibious robot (WSP-bot) that can operate on flat and rough terrains, water surfaces, and water-land transitional zones. The proposed robot relies on a propulsion mechanism called transformable wheel-spoke-paddle (WSP), which combines the stability of wheeled robots with the obstacle-climbing capability of legged robots, while also providing additional aquatic mobility. The utilization of a crank-slider-based transformation mechanism enables seamless switching between multiple motion modes. An analysis of mode transition and ground motion in spoke mode was conducted, along with an investigation of its obstacle-crossing capability. Simulations were performed for mode transition, ground locomotion, and obstacle-crossing, as well as propulsion of a single WSP module on water. Based on the above work, a prototype robot was manufactured. Prototype tests, including mode transition and mobility tests on land and water surfaces under multimodal states, confirmed the effectiveness of the proposed WSP-bot.
Making space for singing in the 21st century classroom – A focus group interview study with primary school music teachers in Sweden
Authors: Bojner Horwitz Eva , Thorarinn Johnson David , Lyberg-Åhlander Viveka , Sahlén Birgitta , Laukka Petri , Bygdéus Pia 
Published: December 2023

AbstractThe present study aimed to increase understanding of how singing activities may be initiated in primary school, and what support and assistance teachers require to conduct singing activities as an integrated part of the school day. Five music teachers participated in a focus group interview. The following main themes were identified: 1) pedagogical and methodological flexibility, 2) the role of routines and familiarity, 3) the embodied and multimodal dimensions of singing, 4) the importance of accompaniment and instruments, 5) the experience of insecurity and obstacles and 6) the perceived synergies between singing and other learning activities. This knowledge may be important to integrate within music teacher education in order to secure singing’s place in schools.
Manipulation without Resistance: Consensus Elections in Rural China
Authors: Liu Jingping 
Published: December 2023

AbstractThe Chinese Communist Party has been increasing its control over village elections since the early 2010s, yet this move has not triggered any widespread popular resistance. Drawing on ethnographic evidence from village elections held in 2017 in a county in Hunan province, I conceptualize a form of electoral manipulation I term “consensus elections,” in which the Party engineers a pre-electoral consensus with ordinary villagers on whom to select while deterring challenges from village elites. Consensus elections are rooted in the Chinese political elites’ ideal that favours electoral participation over competition. While participation increases regime legitimacy, competition threatens regime authority. Propaganda promoting this electoral ideal shapes the views of ordinary villagers, laying a basis of legitimacy on consensus elections. The villagers embraced voting as being oriented by a unitary common interest and developed a cynicism whereby campaigning was equated with corruption. Comparison of the processes involved in engineering consensus elections in five villages suggests popular support for such elections. Whereas popular resistance was mounted against the lack of participation, popular complicity helps the Party to deter challenges from village elites. Consensus elections have facilitated the fall of Chinese village elections without undermining the Party's legitimacy, but consensus elections will also encourage more political challenges from village elites through non-institutionalized channels.
Relational values shape people’s connectedness to nature in a former military protected area of Ecuador
Authors: Asanza-Reyes Christian Oswaldo , Castro Antonio J , Requena-Mullor Juan Miguel , López-Rodríguez María Dolores , Quintas-Soriano Cristina 
Published: December 2023

SummaryRelational values are a way of recognizing and valuing the complex and interconnected relationships between people and nature, such as caregiving, place attachment and spiritual meaning, as well as the social and cultural impacts of degradation and environmental and conservation efforts. However, the implications of these values for the management and conservation of protected areas are little known. We explored the role of relational values in shaping local communities’ connectedness to a protected area of Ecuador that had been used by the military in the past and the implications of the values for well-being. Four hundred individual face-to-face surveys in the surroundings of Arenillas Ecological Reserve (south-west Ecuador) indicated high levels of connectedness towards this natural reserve amongst local communities through multiple values of nature. However, relational values were identified as the most prominent value explaining the strength of connectedness to nature, followed by intrinsic and instrumental values. We also showed that combinations of different natural values (instrumental, intrinsic and relational) might explain the support for specific well-being components. Our findings offer understanding of human behaviour towards protected areas with a military past and represent a first step in Ecuador towards comprehending how relational values shape the connectedness of local communities to nature.
Chylothorax related to acute SARS-CoV-2 infection in a patient with Noonan syndrome with prior uncomplicated cardiac surgeries
Authors: Ehsan Lubaina , Thoe Jessica A. , Parent John J. , Fakhoury Joseph D. 
Published: December 2023

AbstractSARS-CoV-2 is a novel coronavirus that has rarely been associated with chylothorax. Patients with Noonan syndrome are at risk for developing chylothorax, especially after cardiothoracic interventions. We present the case of SARS-CoV-2 infection triggering the underlying tendency of a patient with Noonan syndrome to develop chylothorax who did not develop it even after prior cardiothoracic interventions. Patient presented in respiratory distress without hypoxia and was found, on imaging, to have a large right-sided pleural effusion, which was eventually classified as chylothorax. The patient was then started on a low-fat diet. Chest tube drainage substantially reduced the effusion in size, and it remained stable. Our report highlights that SARS-CoV-2 infection can cause the development of a chylothorax or a chylous effusion in patients with Noonan syndrome or among populations with a similar predisposition. A high index of suspicion in vulnerable patients or those not responding to traditional therapy should exist with providers, thus leading to the testing of the fluid to confirm the diagnosis.
54 Age-Related Differences in the Associations Between Cannabis Use and Cognition in People Living with HIV (PLWH)
Authors: DeFelice Jason S , Cook Robert L , Cohen Ronald A , Porges Eric C 
Published: December 2023

Objective:PLWH report using cannabis for both recreational reasons and HIV symptom management (e.g., nausea, pain, depression/anxiety). Recent literature suggests that cannabis may attenuate HIV symptoms and neuroinflammation, which are strongly related to neurocognition. Additionally, older adults who are particularly vulnerable to cognitive impairment experience a decline in the endogenous cannabinoid system with age. Therefore, the aims of the present study were 1) to determine if cannabis use is associated with cognitive performance in PLWH, 2) to determine if age moderates the relationship between cannabis use and cognition in PLWH, and 3) to determine if there are differences in cognition in cannabis non-users, occasional users, and daily users among PLWH.Participants and Methods:The sample included 225 PLWH (78% undetectable; 51% female, Mean age=49.10) who were classified as non-users (n=52), occasional users (n=53), or daily users (n=120). Cannabis use was measured via the Timeline Follow-back (TLFB). Cognition was examined using the NIH Toolbox Cognition Battery, which included measures of attention, working memory, executive function, processing speed, and episodic memory, as well as a fluid cognition composite score.Results:Increased frequency of cannabis use was weakly positively associated with episodic memory performance, r(224) = 0.15, p<0.05. Results of the multiple regression indicate that frequency of cannabis use was not significantly associated with any of the six cognitive domains. However, there was a significant interaction between age and cannabis use in the domains of attention (ß= 0.13, p < 0.05), working memory (ß= 0.12, p < 0.05), and episodic memory (ß= 0.15, p < 0.05), suggesting worse cognitive performance in older adults who use cannabis as compared to younger adults in this sample. When participants were grouped based on use status, there were no significant main effects of group.Conclusions:After controlling for the effects of demographic factors and HIV disease severity, no significant negative associations between cannabis use and cognition were observed, suggesting that cannabis use is not related to cognitive impairment in PLWH. However, results were clarified by a significant interaction, indicating that older adults who use cannabis perform worse in the domains of attention, working memory, and episodic memory compared to younger adults, suggesting synergistic cognitive effects of age and cannabis use. We additionally found preliminary evidence for a potential positive effect of cannabis use on episodic memory in the overall sample. Future studies examining biological and behavioral mechanisms of improvement will be necessary to better examine this relationship.
1 Significant Psychiatric Burden Exists in Women Veterans with Drug-Resistant Epilepsy
Authors: Sullivan-Baca Erin , Rehman Rizwana , Miller Brian I , Haneef Zulfi 
Published: December 2023

Objective:Epilepsy, and specifically drug-resistant epilepsy (DRE), is associated with an increased risk of psychiatric dysfunction, likely due to a combination of physiological mechanisms, emotional reactions to disease burden, and bi-directional influences. Women with epilepsy warrant special consideration due to many factors, including hormonal influences on seizure susceptibility, reproductive health considerations, and unique psychiatric and clinical profiles. However, there is yet to be large-scale research characterizing women with DRE. The present study characterized psychiatric conditions, treatment, and hospitalization data in a Veterans Health Administration (VHA)-wide sample of women Veterans and then compared results to a male Veteran sample to explore sex differences.Participants and Methods:Data from 52,579 Veterans enrolled in VHA care between FY2014 and 2nd Quarter FY2020 were gathered from the VHA Corporate Data Warehouse administrative data. The sample was comprised of 5,983 women (11.4%) and 46,596 men (88.6%). Demographics, psychiatric diagnoses, psychiatric medications, ER visits, and hospitalizations were characterized. Chi-square analyses were used to examine group differences between men and women.Results:The vast majority of the women Veteran sample had at least one psychiatric diagnosis (86.1%), with over half of the sample diagnosed with depression (68.3%), PTSD (54.1%), and/or anxiety disorders (57.7%). When compared to men, women Veterans were more likely to have a psychiatric diagnosis (86.1% vs. 68.1%), evidenced a higher number of co-morbid psychiatric conditions (2.4 vs. 1.6), and were prescribed more psychiatric medications (3.4 vs. 2.3; all significant at p<0.001). All individual psychiatric diagnoses were more prevalent in women than men and, notably, suicidality was also higher in women (13.5% vs. 10.0%; p < 0.001). Women Veterans also had a higher number of ER visits (6.9 vs. 5.5; p < 0.001) and psychiatric hospitalizations than men (.4 vs. .3, p < 0.001).Conclusions:The present study represents the largest known investigation to date of women with DRE and is also the largest study of women Veterans with any form of epilepsy. It highlights a vast psychiatric burden in this subset of women Veterans, with high rates of psychiatric comorbidity, lending to downstream effects on psychiatric medication burden and risk for emergency care usage and psychiatric hospitalization. Comparisons to men emphasize that women are differentially impacted by the psychiatric toll of DRE and warrant special consideration. The markedly higher rates of depressive disorders and suicidality in women Veterans with DRE is especially notable when considering risk of harm and mortality. Overall, the present work adds to the paucity of literature of women Veterans with seizures and gaps in the broader DRE research base, with implications for specialized screening and maximizing treatment interventions in this population.