bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pioglitazone attenuate level of myeloperoxidases and nitic oxide in psoriatic lesion: a proof-of-concept study in a imiquimod induced psoriasis model in rat
Authors: Chatterjee Oishani , Sur Debjeet 
Published: February 2024

Abstract

Objectives
Psoriasis is a persistent autoimmune inflammatory condition that is primarily affecting the skin. Pioglitazone (PGZ), a peroxisome proliferator activated receptor gamma (PPARγ) agonist, has been reported to have anti-inflammatory effects. However, the role of PGZ in psoriatic disease remains unclear. In this study, we aimed to repurpose the use of the PGZ for the treatment of psoriasis.

Methods
To investigate its efficacy, we employed an imiquimod (IMQ)-induced rat model. Wistar rats are randomly allocated to four different groups. Group, I served as a negative control, Group II IMQ control, Group III was treated with pioglitazone hydrogel and Group IV received standard drug betamethasone cream. PASI score was monitored on every alternative day and on day 7 animals were sacrificed and histopathology of skin was performed. Level of nitric oxide (NO) and myeloperoxidase (MPO) was also performed using established methods.

Results
The results of the experiment revealed that treatment with PGZ significantly (p<0.05) reduced redness, scaling, and skin thickening, surpassing the effectiveness of standard drugs. Our result also indicates that PGZ significantly (p<0.05) inhibits the release of both MPO and NO from the psoriatic lesions.

Conclusions
PGZ effectively reduces the severity of psoriasis possibly by inhibiting the accumulation of neutrophil at the psoriatic area which indirectly regulates the release of NO in the affected area. Our study showed we can repurpose the PGZ for the management of psoriasis.
Crystal structure of catena-poly[aqua-(μ
2-4,4′-diimidazole diphenyl ether-κ
2
N:N′)-(sulfato-κ
1
O)-cobalt(II)] – dimethylformamide (2/1), C39H37CoN9O8S
Authors: Ding Xinyan , Gao Liguo 
Published: February 2024

Abstract
C39H37CoN9O8S, monoclinic, P21/m (no. 11), a = 8.5267(5) Å, b = 20.1577(12) Å, c = 11.2333(7) Å, β = 105.493(7)°, V = 1860.6(2) Å3, Z = 2, Rgt
(F) = 0.0443, wRref
(F
2) = 0.0968, T = 293(2) K.
The crystal structure of samarium sulfate pentahydrate, Sm2(SO4)3(H2O)5
Authors: Li Ming , Wang Xiaofei , Mao Chunyan 
Published: February 2024

Abstract
Sm2(SO4)3(H2O)5, monoclinic, C2/c (no. 15), a = 15.653(3) Å, b = 9.5369(19) Å, c = 10.199(2) Å, β = 120.36(3)°, V = 1313.9(6) Å3, Z = 1, R

gt
(F) = 0.0281, wR

ref
(F
2) = 0.0664, T = 293 K.
Crystal structure of 3-(difluoromethyl)-1-methyl-N-(pyridin-2-yl)-1H-pyrazole-4-carboxamide, C11H10F2N4O
Authors: Zi-Yin Xie , Shu-Zhen Xiao , Jie Wang , Shu-Juan Liu , Da-Yong Peng 
Published: February 2024

Abstract
C11H10F2N4O, monoclinic, P21/n (no. 14), a = 8.7616(10) Å, b = 14.2418(17) Å, c = 9.7191(12) Å, β = 107.6020°, V = 1156.0(2) Å3, Z = 4, R

gt
(F) = 0.0431, wR

ref
(F
2) = 0.1263, T = 296(2) K.
EU Finalité Conceptions After Brexit: A Comparison of Polish and German Parties
Authors: Mehlhausen Thomas , Wagstyl Adrian , Karolewski Ireneusz Pawel , Grzeszczak Robert 
Published: February 2024

Abstract
The future of the EU as a laboratory of a transnational community of nations within an increasingly split global community of actors could become ever more relevant, the more the global future of democracy needs transnational cooperation among differently structured democracies. Yet the reality on the ground is complex in the heartland of the respective experimentation as well. Against this backdrop, the article deals with deepening and differentiation of European integration through the prism of two cases: Germany and Poland. While the former is the most populous among fully integrated EU member states, the latter is by now the biggest partially integrated member state having not yet joined the Eurozone, nor showing any inclination to do so in the future. These countries differ in many respects, to name just the Eurozone, defense matters, rule of law, and migration. And yet, in the eyes of some observers, close German-Polish cooperation is just as essential for the future of Europe as the Franco-German partnership. In this sense, the comparison of Poland and Germany promises to unveil problématiques typical for the entire EU, in particular with regard to differentiated integration.
Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
Authors: Suhartati Tati , Irawan Andi , Ropingi Hendri , Yandri Yandri , Hadi Sutopo 
Published: February 2024

Abstract
In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.) and subsequently tested as antidiabetic and antibacterial agent against Staphylococcus aureus and Salmonella typhi. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC50 value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. S. aureus and S. typhi bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).
Non-destructive assay of plutonium in absence of gamma-ray spectrometry
Authors: Chaudhury Sanhita , Kumar Ashwani , Patra Sabyasachi , Tripathi Rahul 
Published: February 2024

Abstract
Gamma-ray spectrometry-based isotopic composition analysis is a prerequisite for absolute non-destructive assay of Pu by neutron counting or calorimetry. However, gamma-ray spectrometry can be complicated in samples that are heavily shielded or have a high 241Am fraction. Herein, for the absolute non-destructive assay of Pu, a simple yet potent empirical methodology combining neutron multiplicity counting and calorimetry is proposed, which obviates the need for gamma-ray spectrometry-based isotopic composition analysis. The approach includes stepwise correlation between the parameters obtained from neutron multiplicity counting, i.e., α ((α, n) neutron to spontaneous fission neutron ratio), effective mass of 240Pu, and D (doubles neutron rate) with the thermal power output (W
Pu) due to radioactive decay (measured by calorimetry). Because D and W
Pu both are governed by the Pu isotopic composition, their correlation should be sensitive to the isotopic information in a given sample. Mandatory correction for the 241Am contribution in W
Pu was done using the linear plot between its weight fraction and the corresponding α. The proposed methodology was validated by analyzing several PuO2 standards containing high 241Am fraction (0.02–0.09). The measured Pu amounts were within 8 % of the actual values with measurement uncertainties between 8 and 10 %, which shows the potential of the proposed methodology for the assay of samples having high 241Am content or for the quantification of Pu in heavily shielded samples.
Preliminary Results of Rib Osteosynthesis at the Teaching Hospital Sylvanus Olympio in Lomé
Authors: Damessane Lamboni , Rabiou Sani , Bignandi Kondoh , Akpoto Yao , Keheou Palissam , Alassani Tarek , Abalo Anani 
Published: February 2024

Introduction: Flaps and rib fractures can be life-threatening due to disruption of hematosis. In certain “many” situations, it is important to quickly restore parietal rigidity by costal osteosynthesis. The objective of our work is to report the surgical results of a first Togolese series of rib osteosynthesis performed in the context of chest trauma.Patients and methods: We proceed by a retrospective study on a series of patients treated for severe blunt chest trauma and who underwent osteosynthesis from 2020 to 2022. Epidemiological and clinical data, in particular the radiological lesion assessment clinic, the therapeutic measures as well as the immediate operative follow-up were collected.Results: six patients with blunt chest trauma. They were four men and two women whose mean age was 44.4 years. Five patients were admitted for polytrauma and one patient for a serious thoracic trauma. All were admitted to intensive care unit on day 0 of the trauma. The radioclinical assessment had noted staged fractures of ribs and/or thoracic flap with an average of six affected ribs. All the patients presented pleural effusions and benefited from pleural drainage on their admission to intensive care, often after a chest X-ray or after carrying out a chest CT scan or a whole-body CT scan. The indication for rib osteosynthesis was retained on the clinical criteria, in particular the existence of a pleural effusion, the instability of the wall and the impact on hematosis, by the drop in peripheral oxygen saturation (Sp02). Despite oxygen therapy above 6 l/min for more than 4 days, and according to the results of the chest CT scan and the evolution of the patient after the implementation of the means of resuscitation. The osteosynthesis material used was “third tube” orthopedic plates molded intraoperatively in three patients, pelvic plates in one patient. The average number of plates used was 4.5 and that of Vis was 18. Two patients underwent osteosynthesis by Judet staple.Conclusion: rib osteosynthesis contributes to a regression of symptoms, in particular chest pain, to reduce the duration of hospitalization, morbidity and mortality, and then improves the functional respiratory prognosis in the short and long term. Despite our reduced technical platform, the results are generally good, reducing the hospital stay in intensive care. This encourages the practice of surgical management of multiple rib fractures associated or not with a rib flap.
CFD modeling for phase change materials integrated to building envelope
Authors: Saliby Ammar , Kovács Béla 
Published: February 2024

AbstractIntegrating thermal energy storage with thermal conversion systems is necessary to maximize their use. Phase change materials are the best media for storing and releasing thermal energy from various basic material types. Because the phase change materials have a high latent heat of fusion, it is often viable to use these characteristics and include the phase change materials in building envelopes to store thermal energy. The paper provides a thorough categorization of the phase change materials and thermal energy storage systems, in addition to an evaluation of their modeling using computational fluid dynamics. The purpose was to highlight computational fluid dynamics as a useful technique for advancing the engineering of thermal energy storage devices.
Enhancing wind power with permanent magnet synchronous generator control strategies
Authors: Ahyaten Sabra , El Bahaoui Jalal , Amahjour Narjisse , Gallego Francisco Ortegón , Hanafi Issam 
Published: February 2024

AbstractDue to the substantial rise in wind power generation, the direct-drive permanent magnet synchronous generator has emerged as a leading technology for efficient variable speed operation, meeting grid demands effectively. This paper presents a comparative analysis of control strategies for permanent magnet synchronous generator based wind turbine using real variable wind speed data from a 2 MW of Tetouan wind farm in Morocco. The proposed approach is based on evaluating two primary control strategies: the adaptive fuzzy-proportional-integral controller and the conventional proportional-integral controller aimed at enhancing the wind turbine's output power. The simulation performed on MATLAB-Simulink indicates that pitch control mechanisms play a crucial role in optimizing power generation, also demonstrating its ability to achieve satisfactory performance.
Measuring the flex in surfboard fins during surfing
Authors: Krzyzanowski Pawel , in het Panhuis Marc 
Published: February 2024

AbstractIn this paper, we describe the fitting out of a surfboard with inbuilt measurement system and a set of fins instrumented with flex sensors. The inbuilt measurement system consisted of GPS, accelerometers, and gyroscope. Telemetry data were collected during characteristic surfing maneuvers on ocean waves at a sampling rate of up to 80 Hz. Our results indicated that our surfboard with instrumented fins can be used to measure the flex in fins during surfing. Our data showed that both fins flex while on waves (at surfing speed), but not during paddling (at low speed). The commercial sensors recorded fin flex values of up to 10% as the fins are loading and unloading at surfing speeds of up to 6 m/s (from GPS data).
Graphical abstract
Un escenario de aprendizajes para la formación de formadores en TIC
Authors: De-Luca Marina Patricia 
Published: February 2024

La configuración de un escenario de aprendizajes para la formación de formadores en Tecnologías de la información y la comunicación (TIC) es validada y presentada mediante la autopercepción de las competencias digitales docentes (CDD) y de la formación recibida. Con el método de investigación-acción se estudió un espacio curricular de formación semipresencial en TIC de un plan para la formación pedagógica de docentes de nivel superior. Los instrumentos fueron una rúbrica y un grupo focal multimedial, y los resultados de autopercepción sobre las CDD desarrolladas (individuales, en grupos disciplinares e interdisciplinares, y grupal) y sobre la formación recibida reposicionan a quienes se formaron, por lo tanto, validan el escenario y las escenas de la formación. Los muros del salón de clase se traspasaron configurando un escenario de aprendizajes semipresencial en la educación formal que abarcó espacios áulicos, hogareños y ubicuos; con el aula virtual como núcleo de otros entornos y estrategias didácticas.
Abuso Sexual contra Crianças no Contexto da Enfermagem: Uma Análise de Conceito
Authors: Medeiros Tamires Paula Gomes , Nóbrega Igor de Sousa , Bezerra Kalyne de Araújo , Souto Rafaella Queiroga , Monteiro Gleicy Karine Nascimento de Araújo , Marcolino Emanuella de Castro , Rodrigues Renata Clemente dos Santos 
Published: February 2024

Objetivo: Realizar a análise do conceito de abuso sexual em crianças, identificando os possíveis atributos, antecedentes e consequências. Método: Foi conduzida uma análise de conceito, estruturada por meio de uma scoping review. A busca foi realizada em 6 bases de dados e, após análise, um total de 17 artigos foram incluídos. Resultados: Foram identificados, como antecedentes, crianças com idade acima de 8 anos, do sexo feminino, sendo o agressor frequentemente um parente da vítima ou até mesmo o próprio pai. Quanto aos atributos, foram identificadas alterações psicológicas, doenças sexualmente transmissíveis e gravidez indesejada. As consequências observadas foram predominantemente de natureza psicológica, incluindo depressão e comportamento suicida. Conclusão: No total, foram agrupados nove antecedentes que estão relacionados aos fatores que levam à vulnerabilidade do abuso. Além disso, foram identificados 11 atributos correspondentes aos sinais característicos que indicam que uma criança é vítima de abuso. Por fim, foram observadas 12 consequências decorrentes da violência sexual infantil.
Teacher professional development and inquiry-based instruction: literature review
Authors: Khalil Eftima , Gunduz Nuket 
Published: February 2024

Innovative strategies can revolutionise student learning if implemented properly. Nonetheless, teachers need sufficient training to do this. Therefore, teacher professional development programmes should be reviewed to see if they provide sufficient training for teachers to effectively implement inquiry-based instruction, since it is considered one of these innovative methods. This paper synthesises the existing literature on teacher professional development for inquiry-based instruction from the fields of education and social science between 2001 and 2022. The EBSCO host library, Scopus, Science Direct, ProQuest Dissertations & Theses, Linked Papers, and Taylor & Francis data bases were used for this review. The titles, abstracts, keywords, and publication dates of the selected records were converted into Microsoft Excel, where they were then reviewed to identify the publications that were in line with the scope of the study. A total of 135 studies, including articles and dissertations, were reviewed for this study. The findings of this study provide insight into the gaps in the existing literature on inquiry-based instruction and teacher professional development, as well as suggestions for potential areas for further research.
Keywords: education field; innovative methods; inquiry-based instruction; social studies; teacher development
Leukemoid Reaction in an Elderly Patient with Aortic Valve Infective Endocarditis and Pancreatic Adenocarcinoma
Authors: Reznik E. V. , Batov M. A. , Aparina T. V. , Kim O. V. , Shurdumova M. Kh. , Mikhaleva L. M. , Smirnov A. P. , Golukhov G. N. 
Published: February 2024

Leukemoid reaction (LR) associated with solid tumors has been documented for many decades. LR is often associated with an unfavorable prognosis and aggressive course of the disease. However, the differential diagnosis of LR is of significant difficulty when a patient has several potential etiological factors, each of them individually may cause LR or, on the contrary, lead to a systemic reaction of the body within a single pathogenetic chain.We present a clinical observation of an elderly patient admitted to the intensive care unit due to the first-time encountered weakness in the right extremities. Clinical and instrumental examination revealed an acute cerebral ischemia with leukocytosis increase up to 60.000 cells/μL with leukocyte formula left shift and subsequent patient decompensation with lethal outcome, despite the intensive treatment.Autopsy revealed a low-differentiated adenocarcinoma of the pancreatic tail with multiple metastatic lesions in regional lymph nodes and liver, as well as a competing disease — acute infective endocarditis of the aortic valve, which was the cause of sepsis development with septicemia type and thromboembolism both in the great circulation circle with the presence of ischemic cerebral infarction, spleen infarcts, and in the small circle with the development of thromboembolism in the right segmental branches of the pulmonary artery. Given the advanced stage of pancreatic cancer and lack of direct evidence of sepsis at primary diagnosis, paraneoplastic nature of LR is more likely, but infective endocarditis and concomitant pathology also may have contributed to the development of LR.
Safety Responsiveness and Psychological Distress Among Health Care Workers During COVID-19 (2020–2022) in the Pacific Northwest
Authors: Hurtado David A. , Greenspan Samuel A. , Alley Lindsey , Hammer Leslie B. , Furnari Megan , Lenhart Abigail 
Published: February 2024

Objectives. The COVID-19 pandemic imposed unprecedented safety challenges on health care facilities. This study examined whether health care workers who deemed a better safety response to the pandemic by their units or employers experienced lower psychological distress. Methods. Patient care workers at a health care system in the Pacific Northwest were surveyed every 6 to 8 months from May 2020 to May 2022 (n = 3468). Psychological distress was measured with the Well-being Index (range: −2 to 7 points). Safety response was scored on the basis of participants’ ratings (on a 1–5 scale) of equipment sufficiency and responsiveness to safety concerns by their health care system and unit. Results. Adjusted multilevel regressions showed an inverse association between safety responsiveness and psychological distress at the individual level (b = −0.54; 95% confidence interval [CI] = −0.67, −0.41) and the unit level (b = −0.73; 95% CI = −1.46, −0.01). The cross-level interaction was also statistically significant (b = −0.46; 95% CI = −0.87, −0.05). Conclusions. Health care workers who deemed a better response to safety challenges reported lower psychological distress. This study highlights the need for continued efforts to ensure adequate safety resources. ( Am J Public Health. 2024;114(S2):S204–S212. https://doi.org/10.2105/AJPH.2024.307582 )
Surgical Management of Intraosseous Neurofibroma in Cervical Spine
Authors: Iwai Chizuo , Nozawa Satoshi , Fushimi Kazunari , Yamada Kazunari , Akiyama Haruhiko 
Published: February 2024

Case:
A 30-year-old man had cervical radiculomyelopathy and neck pain caused by a massive intraosseous neurofibroma (IONF) originating from the C6 vertebrae. We performed posterior tumor resection with spinal instrumentation and fusion from C3 to T2 and a follow-up resection procedure of the remaining C6 anterior tumor, sacrificing the affected vertebral artery (VA), which accordingly required bypass surgery at 2 months recovery. Reconstruction using a titanium mesh cage was successfully performed. There were no local recurrences at 2 years postoperatively.

Conclusions:
Total tumor resection split into 2 stages with sacrifice of the affected VA is a feasible option for treatment of IONF.
الهوى والشهوة في القرآن الكريم: دراسة دلالية
Authors: Suharto Ahmad , Ardana Pamasa , Badrun Muhammad , Pratiwi Mustikasari Intan 
Published: February 2024

There is disagreement among scholars since the word "Qur'an" has multiple meanings. The Qur'anic phrases "Al-Hawa" and "Al-Syahwah" are examples of pairs of synonymous sentences. At first glance, from the perspective of the second language, the lafadz has almost the same meaning, namely love or pleasure. But the Qur'an gives different meanings from the two lafazh. This study aims to find out the original meaning of lafazh Al-Hawa and Al-Syahwah, find out the difference in meaning by examining the contextual meaning of lafazh Al-Hawa and Al-Syahwah in the Qur'an, to reveal the wisdom contained in the Qur'an as a whole. To examine the differences between the words Al-Hawa and Al-Syahwah in the Qur'an, the author uses a descriptive-analysis method and a semantic approach, namely by examining the words Al-Hawa and Al-Syahwah in terms of linguistic differences. From linguistic differences, it can be concluded that al-Hawa is more inclined to opinions or beliefs that are inclined to negative traits because they neglect the perpetrators. While al-Syahwah is more inclined to the senses that have no effect on the body but affect psychological pleasure that is praiseworthy at one time and can be reprehensible at another time.