bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Removal of Antibiotic Resistance Genes through 4f‐2p‐3d Gradient Orbital Coupling Mediated Fenton‐Like Redox Processes
Authors: Li Fei , Wang Pengfei , Zhang Tao , Li Mingmei , Yue Shuai , Zhan Sihui , Li Yi 
Published: October 2023

AbstractPeroxymonosulfate (PMS) mediated radical and nonradical active substances can synergistically achieve the efficient elimination of antibiotic resistance genes (ARGs). However, enhancing interface electron cycling and optimizing the coupling of the oxygen‐containing intermediates to improve PMS activation kinetics remains a major challenge. Here, Co doped CeVO4 catalyst (Co−CVO) with asymmetric sites was constructed based on Ce 4f−O 2p−Co 3d gradient orbital coupling. The catalyst achieved approximately 2.51×105 copies/mL of extracellular ARGs (eARGs) removal within 15 minutes, exhibited ultrahigh degradation rate (k=1.24 min−1). The effective gradient 4f‐2p‐3d orbital coupling precisely regulates the electron distribution of Ce−O−Co active center microenvironment, while optimizing the electronic structure of Co 3d states (especially the occupancy of eg), promoting the adsorption of oxygen‐containing intermediates. The generated radical and nonradical generated by interfacial electron cycling enhanced by the reduction reaction of PMS at the Ce site and the oxidation reaction at the Co site achieved a significant mineralization rate of ARGs (83.4 %). The efficient removal of ARGs by a continuous flow reactor for 10 hours significantly reduces the ecological risk of ARGs in actual wastewater treatment.
Identification of cold tolerance and some agronomic traits of advanced safflower genotypes developed by hybridization
Authors: Culpan Emrullah 
Published: October 2023

AbstractThe development of winter‐tolerant safflower genotypes is crucial for the improvement of global safflower agriculture. The aim of the present study was to determine the cold tolerance abilities and some agricultural characteristics of advanced safflower genotypes. For this purpose, 10 advanced safflower genotypes were used in four different locations. The experimental design was a randomized complete block design with three replications. Winter survival and agricultural characteristics were significantly affected by growing season, location and genotype. Winter survival varies between 86.43% and 93.91% among the genotypes which is promising for winter sowing. As the average of 2 years, the highest oil content (36.25%) was observed in genotype EC21 and it was followed by genotypes EC11 (35.51%) and EC20 (35.49%). As with the seed yield, the high winter survival of genotypes with high oil content is highly promising in terms of winter sowing. Safflower should be grown in winter with mild temperature regions for high seed yield and sustainable safflower production. Therefore, this study focused on winter‐tolerant genotypes that are superior one in terms of seed yield and oil content.
Intelligent self‐healable electroactive carboxymethyl cellulose hydrogel containing conductive polythiophene and acid hydrolyzed cellulose
Authors: Danmatam Nanticha , Pearce John T. H. , Pattavarakorn Datchanee 
Published: October 2023

AbstractSelf‐healable electroactive carboxymethyl cellulose/polythiophene/acid hydrolyzed cellulose (CMC/PTh/AHC) hydrogels were successfully fabricated. AHC particles dispersed well in the CMC matrix improving hydrogels thermal stability. The electro‐responsive performance of the hydrogels was investigated with respect to bending angle and bending sensitivity. The results showed that under an applied electric field, the CMC/PTh/AHC hydrogels bend toward a cathode electrode. In addition, the electroactive performance of the hydrogels decreased with increased AHC content. The CMC/PTh/AHC10 (10 wt.% AHC) hydrogel exhibited the shortest induction time (τind) of 3.35 ± 0.56 s. For self‐healing, it was found that the hydrogel with addition of 2 wt.% AHC had the highest self‐healing efficiency on both tensile strength and elongation at break (93.37 ± 3.17% and 99.35 ± 12.11%, respectively). While the self‐healing efficiency on bending angle was 82.73 ± 14.55%. The results demonstrated that the properties of the CMC/PTh/AHC2 hydrogel were close to its original properties after healing for 24 h. The results demonstrated that the CMC/PTh/AHC hydrogel can be utilized as an actuator or artificial muscle using electrical stimulus.
Simultaneous marginal homogeneity versus directional alternatives for multivariate binary data with application to circular economy assessments
Authors: Bonnini Stefano , Borghesi Michela , Giacalone Massimiliano 
Published: October 2023

AbstractCommodity price volatility is a major source of instability in those countries that are primarily commodity‐dependent and has a negative impact, especially on economic growth. With this premise, commodities represent an effective financial exchange tool that nowadays finds relevance in being involved in the processes inherent to environmental sustainability. This work focus on raw materials and their demand, connected with the need for a transition towards the Circular Economy, as part of a strategy to address commodity supply disruptions. It presupposes changes in the mentality and behavior of companies in the various economic sectors. A crucial issue debated in the literature concerns whether or not the size of the companies favors their attitude towards Circular Economy. We propose a nonparametric method to test the effect of firm size on their propensity to undertake Circular Economy activities. Considering of such activities, this propensity is a multidimensional concept and it can be represented by a ‐dimensional vector of proportions. Each element of the vector represents the share of companies of the population under study that implement a specific Circular Economy activity. The main difficulty of such a multivariate testing problem, together with the multidimensional nature of the dichotomous response, is the one‐sided type alternative, which is a stochastic dominance for multidimensional binary variables. A Monte Carlo simulation study proves the good power behavior of the proposed solution, based on a nonparametric approach. Case studies related to Italian small and medium enterprises in some strategic sectors are also addressed.
Optimization and validation of a bioanalytical HPLC–UV technique for simultaneous determination of underivatized phenylalanine and tyrosine in the blood for phenylketonuria diagnosis and monitoring
Authors: Rabti Hadjira , Amrane Mounira , Lalaouna Abdeldjalil , Flilissa Abdenacer , Benguerba Yacine 
Published: October 2023

AbstractThis study aimed to develop a fast, accurate, and precise high‐performance liquid chromatography with UV detection method for simultaneous analysis of underivatized phenylalanine (Phe) and tyrosine (Tyr) in biological samples. Separation of the analytes was accomplished using a Discovery HS F5‐3 column, which offered better retention and peak symmetry for the tested analytes. Chromatographic conditions were optimized using central composite experimental design, and three factors were investigated: the concentration of ammonium acetate (A), the acetonitrile proportion in the mobile phase (B) and the column oven temperature (C). The approach was verified using β‐expectation tolerance intervals for total error measurement that did not exceed 15%. Optimal settings were A = 50 mm, B = 24% and C = 28°C. The method applicability was determined using human plasma from 75 volunteers. The limits of detection and quantification of the technique were satisfactory at 9 and 29 μm for Phe and 4 and 13 μm for Tyr. The mean analytical bias in spiking levels was acceptable, ranging from −1.649 to +1.659% for both substances, with RSD <5% in all instances. The suggested approach was successfully used to analyze Phe and Tyr in human blood samples and calculate the Phe/Tyr ratio.
Voice analysis results in individuals with Alzheimer's disease: How do age and cognitive status affect voice parameters?
Authors: Parlak Mümüne Merve , Saylam Güleser , Babademez Mehmet Ali , Munis Özlem Bizpınar , Tokgöz Sibel Alicura 
Published: October 2023

AbstractBackgroundReports of acoustic changes in the voice in individuals with Alzheimer's disease (AD) and the relationship of acoustic changes with age and cognitive status are still limited.ObjectiveThis study aims to determine the changes in voice analysis results in AD, as well as the effects of age and cognitive status on voice parameters.MethodsThe study included 47 (AD: 30; healthy: 17) women with a mean age of 76.13 years. The acoustic voice parameters mean fundamental frequency (F0), relative average perturbation (RAP), jitter percent (Jitt), shimmer percent (Shim), and noise‐to‐harmonic ratio were detected. The mini‐mental state examination (MMSE) was utilized.ResultsF0, Shim, Jitt, and RAP values were found to be statistically significantly higher in individuals with AD compared to healthy individuals. There was a significant negative correlation between MMSE and F0, Jitt, RAP and Shim, and the MMSE score had a significant negative effect on F0, Jitt, and RAP (p < .05).ConclusionCognitive status was discovered to significantly impact the voice, with fundamental frequency and frequency and amplitude perturbations increasing as cognitive level decreases. In order to contribute to the therapy process for voice disorders, cognitive functions can be focused on in addition to voice therapy.
Do environmental scores become multinational corporations' strategic “greenwashing” tool for window‐dressing carbon reduction? A cross‐cultural analysis
Authors: Peng Xuhui , Li Jingduan , Tang Qingliang , Lan Yi‐Chen , Cui Xinjian 
Published: October 2023

AbstractOwing to the urgency of the climate change crisis and the emerging greenwashing issue that companies face, greenwashing in companies' carbon reduction is exceptionally important in the progress of global carbon reduction and the achievement of the Paris Agreement goals. Therefore, this study focused on multinational corporations (MNCs) listed on the 2021 Fortune Global 500 list (2001–2020) and used institutional theory to theoretically discuss and empirically test the relationship between MNCs' environmental scores and carbon emissions/intensity, as well as the moderating effect of national culture. Our results demonstrate that the environmental scores of MNCs positively affect their carbon emissions and intensity, meaning that managers tend to use high scores to hide their poor carbon reduction, showing a typical “talk” more and “act” less (i.e., greenwashing) behavior. Meanwhile, the moderating effects of individualism, masculinity, and uncertainty avoidance were negative. These revealed that the balance of MNCs' “talk” and “act” can be influenced by the domestic national cultural characteristics. Further analysis showed that the Paris Agreement did not prevent MNCs' greenwashing in carbon reduction. Such greenwashing behavior has become even worse in societies with power distance characteristics after the Paris Agreement. To the best of our knowledge, this is the first study to investigate companies' greenwashing in terms of carbon reduction. The goal is to enhance our understanding of why and how greenwashing occurs based on the institutional theory perspective, extend the application of institutional theory, enrich the literature on companies' greenwashing and national culture, and offer insight into interdisciplinary research between national culture and green transition management. Finally, suggestions for policymakers on how to prevent MNCs' greenwashing in carbon reduction, considering national cultural influence, were provided.
Efficacy of breast reconstruction for N2‐3M0 stage female breast cancer on breast cancer‐specific survival: A population‐based propensity score analysis
Authors: Zhao Yuting , Yan Lutong , Li Shouyu , Yang Zejian , Chai Na , Qiu Pei , Zhang Huimin , He Jianjun , Zhou Can 
Published: October 2023

AbstractBackgroundThe efficacy of breast reconstruction for patients with N2‐3M0 stage female breast cancer (FBC) remained unclear due to the lack of randomized clinical trials. This retrospective study aimed to explore the efficacy of breast reconstruction for patients with N2‐3M0 stage FBC.MethodsTwo thousand five hundred forty‐five subjects with FBC staged by N2‐3M0 from 2010 to 2016 were retrieved from the Surveillance, Epidemiology, and End Results database. Generalized boosted model (GBM) and propensity score matching (PSM) analyses and multivariable Cox analyses were employed to assess the clinical prognostic effect of postmastectomy reconstruction for patients with N2‐3M0 stage FBC in breast cancer‐specific survival (BCSS).ResultsTotally, 1784 candidates underwent mastectomy alone (mastectomy group), and 761 candidates underwent postmastectomy reconstruction (PMbR group), with 418 breast‐specific deaths after a median follow‐up time of 57 months (ranging from 7 to 227 months). BCSS in the mastectomy group showed no statistical difference from that in the PMbR group in the PSM cohort (HR = 0.93, 95% CI: 0.70–1.25, p = 0.400) and GBM cohort (HR = 0.75, 95% CI: 0.56–1.01, p = 0.057). In the multivariate analyses, there was no difference in the effect of PMbR and mastectomy on BCSS in the original cohort (HR = 0.85, 95% CI: 0.66–1.09, p = 0.197), PSM cohort (HR = 0.86, 95% CI: 0.64–1.15, p = 0.310), and GBM cohort (HR = 0.84, 95% CI: 0.61–1.17, p = 0.298). Triple‐negative breast cancer (TNBC) was a detrimental factor affecting BCSS for patients in the PMbR group.ConclusionsOur study demonstrated that PMbR is an oncologically safe surgical treatment and can be widely recommended in clinics for females with non‐TNBC staged by T0‐3N2‐3M0.
Roles of long noncoding RNA in triple‐negative breast cancer
Authors: Das Plabon Kumar , Siddika Ayesha , Rashel Khan Mohammad , Auwal Abdul , Soha Kazi , Rahman Md. Arifur , Pillai Suja , Islam Farhadul 
Published: October 2023

AbstractIntroductionLong noncoding RNAs (lncRNAs) play crucial roles in regulating various hallmarks in cancers. Triple‐negative (Estrogen receptor, ER; Human epidermal growth factor receptor 2, HER2; Progesterone receptor, PR) breast cancer (TNBC) is the most aggressive form of breast cancers with a poor prognosis and no available molecular targeted therapy.MethodsWe reviewed the current literature on the roles of lncRNAs in the pathogenesis, therapy resistance, and prognosis of patients with TBNC.ResultsLncRNAs are associated with TNBC pathogenesis, therapy resistance, and prognosis. For example, lncRNAs such as small nucleolar RNA host gene 12 (SNHG12), highly upregulated in liver cancer (HULC) HOX transcript antisense intergenic RNA (HOTAIR), lincRNA‐regulator of reprogramming (LincRNA‐ROR), etc., are aberrantly expressed in TNBC and are involved in the pathogenesis of the disease. LncRNAs act as a decoy, scaffold, or sponge to regulate the expression of genes, miRNAs, and transcription factors associated with pathogenesis and progression of TNBC. Moreover, lncRNAs such as ferritin heavy chain 1 pseudogene 3 (FTH1P3), BMP/OP‐responsive gene (BORG) contributes to the therapy resistance property of TNBC through activating ABCB1 (ATP‐binding cassette subfamily B member 1) drug efflux pumps by increasing DNA repair capacity or by inducing signaling pathway involved in therapeutic resistance.ConclusionIn this review, we outline the functions of various lncRNAs along with their molecular mechanisms involved in the pathogenesis, therapeutic resistance of TBNC. Also, the prognostic implications of lncRNAs in patients with TNBC is illustrated. Moreover, potential strategies targeting lncRNAs against highly aggressive TNBC is discussed in this review.
Profiles of volunteers' motivations and positive experiences relate to their sustained volunteering during the COVID‐19 pandemic
Authors: Qu Guoliang , Ju Enxia , Qin Guanglun , Chen Xuhai , Luo Yangmei 
Published: October 2023

AbstractVolunteering benefits individuals and society but is hard to sustain, especially in emergencies. Based on the volunteer process model and self‐determination theory, this study identified the optimal number of motivations and positive experiences profiles and investigated these profiles' relationships with volunteers' sustained volunteering during the COVID‐19 pandemic. Seven hundred and eighteen volunteers completed a series of measures about motivations to volunteer (e.g., autonomous and controlled), positive experiences (e.g., satisfaction, meaningfulness and happiness) and sustained volunteering. Results indicated that meaningfulness and happiness positively predicted sustained volunteering but satisfaction did not. Furthermore, we identified four distinct groups using latent profile analysis: the highest autonomy‐best experience group (34.96%), high autonomy‐well experience group (44.84%), moderate autonomy‐general experience group (17.83%) and low autonomy‐bad experience group (2.37%). Volunteers in the highest autonomy‐best experience group showed the highest level of sustained volunteering compared to those in other groups. These findings suggest that volunteers' motivations and positive experiences play a combined role in sustained volunteering. They also have significance for fostering long‐term volunteering. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Synergistic effect of doxycycline and aqueous extract of irradiated khella on structure of nanobacteria isolated from kidney stones: In vitro and in vivo studies
Authors: Fayez Nora , Ibrahim Mohamed Khaled , Farrag Hala Abdullah , Mohamed Marwa Abd El Hameed , Tablawy Seham Yousef El 
Published: October 2023

AbstractKidney stones have been associated with an increased risk of chronic kidney diseases, end‐stage renal failure. This study is devoted to isolate nanobacteria from patients with active urolithiasis and investigate the in vitro and in vivo antinanobacterial activity of some antibiotics alone or in combination with extracts of irradiated herbs from certain medicinal plants. Nanobacteria were detected using scanning (SEM) and transmission (TEM) electron microscopy, protein electrophoresis (SDS‐PAGE) and DNA profile. The antimicrobial susceptibility of some biofilm‐producing nanobacterial isolates was evaluated. The effect of medicinal plant extracts on growth was tested. A combination treatment between the most potent extracts and antibiotics was tested on biofilm production, protein profile, release of 260 nm absorbing material, protein content, and ultrastructure of the strongest biofilm producers. In vivo study of nanobacteria and its treatment by the most potent agents was evaluated on male rats. Renal function was measured in serum; histological examination and oxidative stress parameters were determined in kidney tissues. Results showed that streptomycin, trimethoprim/sulfamethoxazole, doxycycline, and water extracts of irradiated khella at 6 kGy had antinanobacterial activity. Meanwhile, the synergistic effect of the aqueous extract of irradiated Khella and doxycycline showed higher inhibition activity on microbial growth and biofilm production. They affected dramatically the strength of its cell membrane and subsequently its ultrastructure. Moreover, these results are confirmed by ameliorations in renal function and histological alterations. It could be concluded that the combination of DO and an aqueous extract of irradiated khella has an antinephrotoxic effect against nanobacteria‐induced renal toxicity.
Incidence and predictors of 30‐day and 6‐month stroke after TAVR: Insights from the multicenter OBSERVANT II study
Authors: Gorla Riccardo , Tua Lorenzo , D'Errigo Paola , Barbanti Marco , Biancari Fausto , Tarantini Giuseppe , Badoni Gabriella , Ussia Gian Paolo , Ranucci Marco , Bedogni Francesco , Baglio Giovanni , Rosato Stefano ,   the OBSERVANT II Research Group
Published: October 2023

AbstractBackgroundThe incidence and predictors of 30‐day stroke after transcatheter aortic valve replacement (TAVR) were derived from early studies investigating first‐generation devices. The incidence of 6‐month stroke and its related predictors are unknown.AimsTo investigate the incidence and to identify procedural and patient‐related predictors of 30‐day and 6‐month stroke after TAVR.MethodsData from 2753 consecutive patients with severe aortic stenosis undergoing TAVR were obtained from the OBSERVANT‐II study, an observational, prospective, multicenter cohort study. The study endpoints were symptomatic 30‐day and 6‐month stroke after TAVR.ResultsThe occurrence of a 30‐day and 6‐month stroke was low (1.3% and 2.4%, respectively) but with significant impact on survival. Aortic valve predilatation (odds ratio [OR]: 2.28, 95% confidence interval [CI]: 1.12–4.65, p = 0.023), diabetes (OR: 3.10, 95% CI: 1.56–6.18, p = 0.001), and left ventricle ejection fraction < 50% (OR: 2.15, 95% CI: 1.04–4.47, p = 0.04) were independent predictors of 30‐day stroke, whereas diabetes (sub‐distribution hazard ratio [SHR]: 2.07, 95% CI: 1.25–3.42, p = 0.004), pre‐existing neurological dysfunction (SHR: 3.92, 95% CI: 1.54–10, p = 0.004), bicuspid valve (SHR: 4.75, 95% CI: 1.44–15.7, p = 0.011), and critical status (SHR: 3.05, 95% CI: 1.21–7.72, p = 0.018) were predictive of 6‐month stroke. Conversely, antiplatelet therapy and anticoagulation were protective factors at both 30 days and 6 months.ConclusionsStroke after TAVR was rare. Predilatation was the only procedural factor predictive of 30‐day stroke, whereas the remaining were patient‐related risk factors, suggesting appropriate risk stratification preoperatively.
A rare type of polyp in the duodenum
Authors: Itami Kumi , Yoshikawa Takaaki , Yazumi Shujiro 
Published: October 2023

Key Clinical MessageAlthough solitary P‐J type hamartomatous polyp in the duodenum is rare, the polyp has malignant potential. We should recognize the entity and resect it with a safety margin in case the polyp exhibits an irregular form.
Graphene Doped Carbon‐Gels and MnO2 for Next Generation of Solid‐State Asymmetric Supercapacitors
Authors: Rey‐Raap Natalia , Flores‐López Samantha L. , dos Santos‐Gómez Lucía , Brigandì Antonino , Thomas Minju , Stoyanova Antonia E. , Lufrano Francesco , Arenillas Ana 
Published: October 2023

AbstractSupercapacitors are playing a very relevant role in many applications due to their capability to supply high power density and long durability. However, there is a growing demand to increase their energy density, in gravimetric and volumetric basis. There are different strategies to increase supercapacitor performance by improving the active materials used in the electrodes, the type of electrolyte used or even the configuration employed in the cell. In this work, a combination of these strategies is presented with the use of different active materials, electrolytes, and symmetric vs. asymmetric configuration. The supercapacitor with asymmetric configuration using the graphene‐doped carbon xerogel in the negative electrode and the manganese oxide in the positive electrode, along with the use of Na+‐form Aquivion electrolyte membrane as solid electrolyte, seems to be a promising combination to obtain a substantial enhancement of both gravimetric and volumetric capacitance. Furthermore, the device presents great stability in a wide operational voltage window from 0 to 1.8 V and with a neutral pH polymer electrolyte which contributes to improve the performance, safety, and long cycle life of the device.