bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Novel Prognostic Model for Lower-Grade Glioma Based on the m6A-regulated Genes
Authors: Zhang Yiling , Luo Na , Li Xiaoyu , Zhu Wenjun , Fu Min , Yang Feng , Chen Ziqi , Zhang Qiang , Peng Bi , Chen Xin , Li Qianxia , Liu Yuanhui , Zhang Yuanyuan , Peng Xiaohong , Hu Guangyuan 
Published: December 2023

Abstract
Background: Methylation of N6-methylandenosine (m6A) has important roles in the growth of tumors and cellular biological processes. The immune system is involved in tumourigenesis and development, and plays a certain role in tumour therapy and in resistance to drugs. There have been no in-depth studies on m6A-related immune markers in Low Grade Glioma (LGG).
Methods: LGG patients' mutation data and gene expression and related clinical information were obtained from the China Glioma Genome Atlas (CGGA) database and The Cancer Genome Atlas (TCGA). The prognostic model was calculated using multivariate Cox, LASSO, univariate Cox and other analytical approaches. All data was classified by two-cluster typing. Finally, we determined the biological role of FBXO4 in glioma cells by quantitative reverse transcription-polymerase chain reaction, cell proliferation assay and cell migration assay.
Results: The prognostic model for LGG worked well. It has an area under the curve over 0.9. The survival curve for the cluster typing and the Sankey diagram showed that high m6A levels corresponded to high expression of m6A regulatory genes and immune genes, and were associated with a higher degree of immune infiltration and lower survival rates. Finally, silencing FBXO4in glioma cell lines can significantly inhibit their proliferation and migration ability.
Conclusion: Prognostic models can accurately and efficiently help investigators analysis the prognosis of LGG patients. And the correlation analysis between m6Ascore and tumor microenvironment can provide a basis for further exploratio. Finally, FBXO4 is an important biomarker for the diagnosis and prognosis of Low Grade Glioma.
Effects of Maxwell velocity slip and Smoluchowski temperature conditions on thermal radiative MHD Fe_3O_4-Al_2O_3-Cu/H_2O tri-hybrid nanofluid flow past an exponential shrinking surface with entropy production: A stability analysis performance
Authors: mandal Gopinath 
Published: December 2023

Abstract
This investigation aims to determine the existence of a dual solution in magnetohydrodynamic (MHD) thermal radiative tri-hybrid nanofluid flow over an exponential shrinking surface by considering mass suction effects at the surface. Furthermore, the impacts of Smoluchowski temperature and Maxwell velocity effects are taken into account. The products on various flow fields are examined for three different types of fluid: mono nanofluid ($Fe_3O_4$/$H_2O$), hybrid nanofluid ( $Fe_3O_4$-$Al_2O_3$/$H_2O$), and tri-hybrid nanofluid ($Fe_3O_4$-$Al_2O_3$-$Cu$/$H_2O$). Estimating entropy production is also included in the current work. The similarity transformation is used to translate the nonlinear partial differential equations (PDEs) into a set of ordinary differential equations (ODEs). The numerical MATLAB function bvp4c is utilized in the construction and solution of governing higher-order nonlinear ODEs. The stability of these numerical solutions is achieved by finding the lowest eigenvalue because of the duality present in the solutions. A minimum eigenvalue that is positive denotes the upper stable solution branch, whereas a minimal eigenvalue that is negative indicates the bottom unstable solution branch. A tabular and graphic analysis is conducted on the impact of emergent factors on temperature, skin friction coefficient, Nusselt number, entropy generation, etc. The results also demonstrate that when mono nanofluid changes to hybrid nanofluid and hybrid nanofluid to tri-hybrid nanofluid, the velocity and profile improve. It has been demonstrated that the fluid's temperature and the pace at which heat is transferred are greatly influenced by the thermal radiation parameter. The magnetic field aggravates flow in the case of a stable solution. The production of entropy is also accelerated considerably by thermal radiation. The current optimization technique offers a new and beneficial insight into the production of plastic films, heat exchangers, polymer sheets, crude oil, and electronic devices. Therefore, it is advised to use the results to create an industrial device setup.
Study on the Impact of Urban Expansion on Ecosystem Service Value and Trade-off Synergy in Zhengzhou-Kaifeng-Port 1
Authors: Jia Qi , Liu Yijie , Zhang Chaoyu , Yin Zekai 
Published: December 2023

Abstract
It is of great significance to analyze and predict the evolution characteristics and trade-off synergies of ecosystem services in rapidly urbanized areas for improving the function of regional ecological restoration. Based on the future land use simulation and the method of equivalent scale estimation, this paper analyzed and predicted the characteristics of ecosystem service value (ESV) from 1990 to 2030, and combined with the correlation index, analyzed the trade-off synergy relationship between ecosystem services in 2030. The results showed that: (1) From 1990 to 2030, ESV in the study area fluctuated and decreased slightly. From 1990 to 2000, ESV decreased significantly, and gradually increased after 2000. As far as ESV is concerned, its regulation service function is the strongest, especially hydrological regulation, accounting for 54.51%. Agricultural production and the transfer in and out of waterspace ecological land are the key factors for the improvement and deterioration of ESV. (2) The spatial pattern of ESV in Zhengzhou-Kaifeng-Port area is higher in the north and lower in the west and the middle and east. Under the scenario of urban development, the decline was the most obvious, while under the scenario of cultivated land protection, ESV tended to be stable in most areas, and the bare land in the middle of the Yellow River continued to turn to agricultural production land, which promoted the increase of ESV. During the study period, the center of gravity of ESV was always located at the junction of Dameng Town and Guandu Town in Zhongmou County, and continued to shift to the northeast. (3) The synergistic relationship of ecosystem services is obvious, and the trade-off relationship is less and mainly exists between regulation and support services. This study is of great significance to accurately grasp the trade-off and synergy relationship of ecosystem service value under rapid urban expansion, and can provide a scientific basis for ecological restoration in rapid urbanization areas represented by Zhengzhou-Kaifeng-Port.
A retrospective analysis of predictors and outcome in patient pronounced thrombocytopenia after sutureless and standard stented aortic valve replacement
Authors: Zientara Alicja , Salmasi Mohammad Yousuf , Chaatrisha Bella Milan , Kapadia Sharan , Bashir Ryan , Cummings Ian , Quarto Cesare , Asimakopoulos George 
Published: December 2023

Abstract
Objectives
Thrombocytopenia following Perceval aortic valve replacement has been described previously with variable outcome. Studies have lacked a robust analysis of platelet fluctuation and factors affecting it. We aimed to statistically describe the trend in thrombocyte variability as compared with conventional aortic valve replacement, and to assess predictors as well as impact on associated outcomes.
Methods
100 consecutive patients with first-time Perceval were retrospectively compared to 219 patients after Perimount Magna Ease valve replacement. The primary outcome was the serial thrombocyte count on day 0–6. Generalized estimating equations were used to analyse the data using fixed-effect models: for the effect of the post-operative day on platelet count, and random-effect models estimating both time-variant (platelets) and time in-variant variables (valve type, age, LV function, pre-op platelet level).
Results
Perceval patients were older (72 ± 1 vs 68 ± 1 years,p < 0.01) with higher NYHA status (3(2–3) vs 2(1–2),p < 0.001). Mean thrombocyte count in the sutureless group was lowest on day 2 (91.9 ± 31.6 vs 121.7 ± 53.8 x103µl− 1), and lower on day 4 (97.9 ± 44) and 6 (110.6 ± 61) compared to the conventional group (157.2 ± 60 and 181.7 ± 79) but did not result in a higher number of transfusions, bleeding or longer hospital stay (p > 0.05). Reduced platelet count was a strong predictor of red cell transfusion in the conventional(p = 0.016), but not in the sutureless group(p = 0.457). Age (Coef − 1.025, 95%CI-1.649 - -0.401,p < 0.001) and CPB-time (Coef 0.186, 95%CI-0.371 - -0.001,p = 0.048) were predictors for lower platelet levels.
Conclusion
Considering the older patient profile treated with Perceval, postoperative thrombocytopenia does not impact on outcome in terms of transfusions, complications or hospital stay.
Concordance of movements and songs enhances receiver responses to multimodal display in the starling
Authors: Rusiecki Stanisław , Ręk Paweł 
Published: December 2023

Abstract
Many animals produce signals that consist of vocalizations and movements to attract mates or deter rivals. We usually consider them as components of a single multimodal signal because they are temporally coordinated. Sometimes, however, this relationship takes on a more complex spatiotemporal character, resembling choreographed music. Timing is important for audio-visual integration, but choreographic concordance requires even more skill and competence from the signaller. Concordance should therefore have a strong impact on receivers; however, little is known about its role in audio-visual perception during natural interactions. We studied the effects of movement and song type concordance in audio-visual displays of the starling, Sturnus vulgaris. Starlings produce two types of movements that naturally appear in specific phrases of songs with a similar temporal structure and amplitude. In an experiment with a taxidermic robotic model, males responded more to concordant audio-visual displays, which are also naturally preferred, than to discordant displays. In contrast, the effect of concordance was independent of the specific combination of movement and song types in a display. Our results indicate that the concordance of movements and songs was critical to the efficacy of the display and suggest that the information that birds gained from concordance could not be obtained by adding information from movements and songs.
Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of Annona muricata ethanolic leaf extract on Porphyromonas gingivalis (ATCC 33277) and Streptococcus sanguinis (ATCC 10556) (In-vitro)
Authors: Alima Indira Rezka Nur , Auerkari Elza Ibrahim , Gultom Ferry Pergamus , Suhartono Antonius Winoto , Pasaribu Roben Suhadi , Auerkari Pertti 
Published: December 2023

Abstract
Background
Periodontitis is an oral disorder triggered by chronic inflammation, and a major cause of human tooth loss. Porphyromonas gingivalis is a prominent component in the etiology of chronic periodontitis which forms a bacterial “red complex” with Tannerella forsythia and Treponema denticola. P. gingivalis can invade the periodontal tissue and lower the host-defense mechanisms by deregulating immune and inflammatory responses. In parallel, Streptococcus sanguinis represents oral commensal bacteria that act as pioneers for bacterial colonization in biofilm formation. A plant of traditional medicine to inhibit bacterial growth is soursop (Annona muricata L.) that contains active chemical compounds, namely alkaloids, phenolics, flavonoids, and tannins.
Aim
The study aimed to determine the antibacterial effectiveness of soursop leaf extract on P. gingivalis and S. sanguinis, and to compare the effect of the extract to that of the positive control of 0.2% chlorhexidine.
Methods
Ethanol extract of soursop leaves was prepared at concentrations of 60, 50, 25, 12,5, 6,25, and 3,125 vol%. The antibacterial effectiveness of soursop leaf extract on P. gingivalis dan S. sanguinis is tested for Minimum Inhibitory Concentration and Minimum Bactericidal Concentration.
Results
The observed MIC values of soursop leaf extract on P. gingivalis and S. sanguinis were 25% and 12,5%, while the MBC values were 50% and 60% (vol), respectively. There were significant differences in the inhibitory concentration of soursop leaf extract and positive control by 0,2% chlorhexidine against both P. gingivalis and S. sanguinis in post-hoc Tukey test (p ≤ 0.05).
Conclusion
Ethanol extract of soursop leaves can effectively inhibit and kill P. gingivalis and S. sanguinis in vitro.
Antibacterial Potential of Ethanol Extract of Plectranthus amboinicus (Lour.) Spreng against Streptococcus mutans serotype C and Streptococcus sanguinis
Authors: Kamilla Devasya Nathania , Auerkari Elza Ibrahim , Gultom Ferry Pergamus , Pasaribu Roben Suhadi , Auerkari Pertti 
Published: December 2023

Abstract
Caries is the most prevalent disease in the world, and in Indonesia its prevalence is 88.8%. While the causative microbial agent of caries is Streptococcus mutans, Streptococcus sanguinis is a primary colonizer related to the formation of oral biofilms. Due to concerns on cost, access and side effects of the commercial solutions, many people still depend on plant-based medicinal alternatives. Plectranthus amboinicus (Lour.) Spreng is such a medicinal plant containing carvacrol and thymol that are known to have antibacterial effects.
Aim: To determine the effectiveness of P. amboinicus extract in inhibiting growth of and killing S. mutans and S. sanguinis.
Methods: Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined to characterize the antibacterial properties of the ethanol extract of P. amboinicus from extract concentrations of 50%, 25%, 12.5%, 6.25 %, and 3.125% (vol) against the two bacterial species.
Results: MIC and MBC levels of the ethanol extract of P. amboinicus against S. mutans were 3.125% and 50%, respectively. The corresponding MIC and MBC levels of the extract against S. sanguinis were respectively 6.25% and 25%l test showed a significant difference between each treatment (p <0.05).
Conclusion: Ethanol extract of P. amboinicus can effectively inhibit growth of and kill S. mutans and S. sanguinis.
Hesperetin-loaded chitosan nanoparticles ameliorate hyperglycemia by regulating key enzymes of carbohydrate metabolism in STZ-induced high-fat diet fed diabetic Wistar rats
Authors: Natarajan Ashokkumar , Radhakrishnan Sivamathi Rathna Priya , Mohan Karthik 
Published: December 2023

Abstract
Type II diabetes mellitus (T2DM) is the most common severe metabolic disease and is considered one of the top five causes of death worldwide. Screening blood glucose levels measured in obese individuals is more effective in identifying undiagnosed individuals than screening tests in the general population and therefore introduces selection bias in detection from a molecular and morphological standpoint, so this paradigm can be used to investigate the antidiabetic efficacy of medicinal plants or herbs. Hesperetin, due to its therapeutic efficacy. Hesperetin has been demonstrated to have positive benefits, however, it falls short of being completely effective because of its weak water solubility and bioavailability. Our study aims to create chitosan nanoparticles with hesperetin to improve antidiabetic effects in rats with obesity-related diabetes caused by a high-fat diet. Accordingly, the experimental animals were made diabetic by feeding them a high-fat diet for 28 days followed by injection of a low dose of streptozotocin (STZ) (35 mg/kg b.w; 0.1 M citrate buffer; pH 4.0) were made diabetic and a significant (P < 0.05) decrease in blood glucose and glycosylated hemoglobin was observed along with an increase in plasma insulin levels. The existence of dimension, shape, and size has been confirmed by characterization investigations such as SEM, zeta potential, particle size analyzer, and FT-IR examination. Blood glucose, insulin levels, total glycogen, and carbohydrate metabolism are biochemical variables. Overall, the 20 mg/kg b.w the effective findings of hesperetin-loaded chitosan nanoparticles (HSPCNPs) demonstrate potent anti-inflammatory, antidiabetic, and antiobesity agents.
Modify the Polyvinylidene Fluoride: Polyacrylonitrile Blend Nanofiber to Improve Membrane Filtration Efficiency.
Authors: Habeeb Salih Abbas 
Published: December 2023

Abstract
With the increasing sources of water pollution, there has been great interest in improving the efficiency of filtration membranes, which comes from obtaining a porous and high membrane surface area by electrospinning. In this research, we worked on producing a membrane from polyvinylidene fluoride (PVDF) and polyacrylonitrile (PAN), then strengthening it with titanium isopropoxide (Tipp) and converting PAN to amidoxime polyacrylonitrile (AOPAN) by reaction. Many physical tests were conducted, such as wettability, field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) to determine the efficiency of the membranes. The developed membrane has high crystalline and thermal properties, and the surface is characterized by high wettability compared to the properties of the undeveloped membrane. On the other hand, the developed membrane has a low pore size and high porosity, which increases the water flux rate to 804 (Lm-2.h-1) and reduces the milk protein flux rate to 145 (Lm-2.h-1), besides increasing the flux recovery ratio, solute rejection, and rejection rate to 91.79%, 89.61%, and 81.97% respectively.
Advancing Personalized Recommendation Algorithms with RNN and Multimodal Features
Authors: Neri Chiara , Ferri Viola , Lombardi Renato 
Published: December 2023

Abstract
Traditional recommendation systems, employing collaborative filtering (CF) methods, recommend related videos for a given seed by considering how many users watched a particular candidate video immediately after the seed video. This approach primarily relies on aggregate user behavior and does not take into account the content of the videos. Current recommendation systems can recommend content across different media types, including text, images, audio, and video. This is achieved by pre-tagging various media files with different labels and then using search engines to find content based on user needs. However, with the evolution of video platforms, user demands for personalization have become stronger, and recommendation scenarios have become more complex. There is an increasing need for precision in video recommendations. To address the limitations, we focus on integrating multiple modalities into recommendation systems. The main contributions of this work are: We explore how to effectively integrate the various modalities to reflect user preferences and how they affect recommendation performance. We perform extensive experiments on public dataset to demonstrate the performance of our proposed model.
Influence of the orientation of constructed blood vessels during the 3D printing on the measurement of the pseudo-oxygen saturation of an artificial blood substitute using conventional oxygen sensors: a test series
Authors: Jung Svenja , Hoffmann Martin , Winkler Dirk , Güresir Erdem , Kropla Fabian , Scholz Sebastian , Grunert Ronny 
Published: December 2023

Abstract

Background: The development of phantoms to reduce animal testing or to validate new instruments or operation techniques is of increasing importance. On this account, a blood circulation-phantom was developed and used to evaluate conventional oxygen sensors for a newly developed spatula for direct measurement of the blood oxygen saturation at the parenchyma.
Methods: A solution of copper and nickel sulfate was used as blood substitute. A total of seven different solutions with a pseudo-saturation between 50 % and 100 % were created. To evaluate the solution as a suitable blood substitute, a two-stage feasibility study was conducted. This study consisted of capturing the absorption spectra of the two sulfate solutions and calibrating the used oxygen sensor. Additionally, blood vessels with a simplified geometry were designed and manufactured using an elastic material (Elastic 50A) with a 3D printer (Formlabs Form 2). To determine the orientation during the printing process, various vessels were printed. Measurements to assess the effects of disturbance (rotation of the vessels during measurements) on the sensor readouts were prepared.
Results: Upon analyzing the absorption spectra of the blood substitute and ordinary blood, it was observed that the components of the solution behaved similarly to oxygenated and deoxygenated blood, confirming the suitability of copper and nickel sulfate as a blood substitute. The impact of disturbances was also verified through the rotation of the 3D-printed vessels. It was shown that a measurement directly on the disturbances led to outliers and higher values. An optimal orientation was determined to be a lateral placement (90° or 270°) of the sensor. Regarding the orientation of the vessels within the printing space, an orientation of 45° yielded the best results, as the individual layers least affected the light emitted and received by the oxygen sensor. All results pertain to constructed vessels developed using a Formlabs Form 2 printer and Elastic 50A material by Formlabs.
Conclusion: The achieved results demonstrate the influence of the orientation of the vessel during 3D printing as well as the influence of the position of the vessel during the measurement using a conventional oxygen sensor.
Oral supplementation of njansan (Ricinodendron heudelotii Bail) and sardine fillets (Sardina pilchardus) oils alleviate high-fat diet-induced obesity in rats by regulating lipid metabolism and stress oxidative parameters
Authors: Florent SOH NDE , Horliane GHOMDIM NZALI , Richard EJOH ABA 
Published: December 2023

Abstract
Background
Obesity has become one of the most common metabolic disorders in the world, characterized by the accumulation of excess fat in the body. Research for natural compounds to improve obesity has become increasingly important. This study aims to explore the effects of Sardina pilchardus and Ricinodendron heudelotii oils on the management of obesity. Njansan (R. heudelotii) oil was extracted by cold pressing using an automatic oil press machine and sardine fish oil by a cooking method. To evaluate the anti-obesity effect of these oils, 6 groups of 6 male Wistar rats were fed different diets: C0 group received a normal diet; HFD was fed a high-fat diet; N1, N2, F1and F2 followed by a high-fat diet supplemented with njansan and sardine oils at 1g/kg body weight/day and 2g/kg body weight/day, respectively.
Results
It appears that regardless of the type of oil, the acid and peroxide values meet the standards prescribed by the Codex Alimentarius. There was an increase in body weight, relative abdominal fat, and liver weight in the HFD group compared to the control group. There was also a decrease in anthropometric parameters such as the Lee index of the HFD group treated with njansan and fish oils, regardless of the concentration. The hyperlipidemic state in the HFD-fed rats was then normalized after treatment with both oils as well as hyperglycemia compared to the control group. Besides, fish and njansan oils attenuated HFD-induced oxidative stress, as indicated by a significant increase CA and SOD.
Conclusion
This study demonstrated that njansan and sardine oils at a low daily dose (1g/kg body weight) can be helpful in managing obesity and also reduce the risk of developing coronary heart diseases.