bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Robot-Based Test Bench for the Destructive Testing of Components
Authors: Reichmann Julia , Hanke Julian , Eymüller Christian , Trauth Anna , Reif Wolfgang , Sause Markus G. R. 
Published: January 2025

Abstract
This paper presents a novel approach for robot-based mechanical testing on the component level using a high degree of flexibility in the superimposition of loads, which allows their application to test various geometries and conditions. To validate our approach, tensile tests were performed using different control modes: position control, force control using a six-axis force/torque sensor, and path control using optical tracking of markers. The last two sensor-guided control modes are used to compensate unwanted force components that may occur in a system with six degrees of freedom. For reference, the same tests were performed on a conventional universal testing machine and were in good agreement. Subsequently, the flexibility of the robot-based test setup is demonstrated by two different component tests; a bicycle frame and a snowboard with high compliance were examined with different load cases. It was demonstrated that in path control mode an improvement in the accuracy of absolute positioning occurs and compensation for any transverse forces is possible. In addition, the path control mode enables the preservation of the initial load vector relative to the surface, even under significant deformation of the component.
Prioritizing working memory resources depends on prefrontal cortex
Authors: Hallenbeck Grace E. , Tardiff Nathan , Sprague Thomas C. , Curtis Clayton E. 
Published: January 2025

How the prefrontal cortex contributes to working memory remains controversial, as theories differ in their emphasis on its role in storing memories versus controlling their content. To adjudicate between these competing ideas, we tested how perturbations to the human (both sexes) lateral prefrontal cortex impact the storage and control aspects of working memory during a task that requires human subjects to allocate resources to memory items based on their behavioral priority. Our computational model made a strong prediction that disruption of this control process would counterintuitively improve memory for low-priority items. Remarkably, transcranial magnetic stimulation of retinotopically-defined superior precentral sulcus, but not intraparietal sulcus, unbalanced the prioritization of resources, improving memory for low-priority items as predicted by the model. Therefore, these results provide direct causal support for models in which the prefrontal cortex controls the allocation of resources that support working memory, rather than simply storing the features of memoranda.Significance statementAlthough higher-order cognition depends on working memory, the resources that support our memory are severely limited in capacity. To mitigate this limitation, we allocate memory resources according to the behavioral relevance of items. Nonetheless, the neural basis of these abilities remains unclear. Here, we tested the hypothesis that a region in lateral prefrontal cortex controls prioritization in working memory. Indeed, perturbing this region with transcranial magnetic stimulation disrupted the prioritization of working memory resources. Our results provide causal evidence for the hypothesis that prefrontal cortex primarily controls the allocation of memory resources, rather than storing the contents of working memory.
Preserving Traditional Knowledge of Prospective Biology Teachers through Science Integrated Learning with Next-Generation Science Standards
Authors: Sukmawati Ika , Widiyatmoko Arif , Tawang Alene , Muhlisin Ahmad 
Published: January 2025

This study aims to find the relationship between prospective biology teachers' ethnicity and teaching skills to preserve indigenous knowledge in Indonesia. The research intervention integrates the Science Integrated Learning (SIL) model with NGSS dimensions in the teaching practices of prospective biology teachers. The method chosen was embedded experimental with a quasi-experimental design consisting of three stages: a qualitative stage before, a qualitative stage during, and a qualitative stage after the intervention. The research targets were 60 prospective science teachers in two different cluster universities, each with 30 prospective teachers. Interpretation of quantitative and qualitative data in the form of statistical test results. The analysis of the comparison test using the t-statistic model obtained a difference in the average score of microteaching practice of 0.3, with an average of the first practice of 2,613 with a standard deviation of 0.3024 and the second practice of 2,921 with a standard deviation of 0.3122. The second microteaching practice experienced an increase in scores from the first practice. The study concluded that prospective biology teachers' skills in preserving indigenous Indonesian traditional knowledge can be realized through the SIL Model integrated with NGSS. The research results allow prospective teachers to utilize students' experiences as learning sources and hopefully can contribute on the development of prospective teacher education policies oriented toward preserving Indigenous knowledge in Indonesia.
Effects of Biology Learning Models on Metacognitive Skills of Senior High School Students
Authors: Ilham Majid  , Roswita M Aboe  , Anissa Novita Sari  
Published: January 2025

The main problem in this study is that many students still rely on memorisation without understanding the concepts deeply, so their ability to plan, monitor and evaluate learning is less developed. In addition, conventional learning models that are often applied in schools tend to provide less opportunity for students to develop metacognitive skills optimally. Therefore, innovation is needed in learning models that can encourage students to think critically and reflect on their learning process. The purpose of this study was to determine the effect of STAD, guided inquiry, and combined STAD and guided inquiry learning models on the metacognitive skills of high school students in Ternate, Indonesia. The research used a quantitative method with a quasi-experimental nonequivalent control group design. The sample consisted of 92 active students in the even semester, selected through purposive sampling. In addition, metacognitive skills were measured using rubrics integrated with test questions. The results showed that the STAD learning model, guided inquiry and a combination of STAD and guided inquiry learning models can improve students' metacognitive skills with a value of Fhitung = 9.317. In addition, the use of STAD learning model, guided inquiry, and the combination of both models showed better metacognitive skills compared to the use of conventional methods. The conclusion of this research is that the learning model applied affects metacognition skills. The combination of STAD and guided inquiry learning models showed the highest achievement of metacognition skills compared to guided inquiry, STAD, and conventional learning models. However, the STAD and guided inquiry learning models showed the effect of metacognition scores that were not significantly different.
Severe palmoplantar keratoderma: a cutaneous complication from sub-optimally controlled type 2 diabetes
Authors: Iqbal Fatima , Phan Kevin , Cheung Wah N 
Published: January 2025

SummaryPalmoplantar keratoderma (PPK), characterised by excessive epidermal thickening of the skin on the palms and/or plantar surfaces of the feet, can be hereditary or acquired. Here, we report a case of a 53-year-old woman with a history of sub-optimally controlled diabetes mellitus presenting with fevers and decreased Glasgow Coma Scale (GCS) to a tertiary hospital. She was diagnosed with diabetic ketoacidosis (DKA), with blood glucose at 40 mmol/L and ketones at 7 mmol/L, in the setting of a methicillin-sensitive Staphylococcus aureus necrotising soft tissue back infection. Her medical history included diabetes managed with insulin but no engagement with an endocrinologist or allied health support. Examination revealed an infected, necrotic back wound on her left mid-upper back that required surgical debridement and broad-spectrum IV antibiotics. In addition, she exhibited marked plantar keratoderma and onychogryphosis, reportedly present and worsening over approximately two years. She was prescribed 40% urea cream twice daily, resulting in gradual sloughing of the hyperkeratotic skin within a few weeks. Her HbA1c was 10.4%, and she tested negative for diabetes antibodies, indicating type 2 diabetes. Treatment included an insulin–dextrose infusion until DKA resolved, followed by twice daily insulin degludec/aspart (Ryzodeg 70/30) and metformin. The PPK was attributed likely secondary to sub-optimally managed diabetes.Learning pointsDiabetes mellitus has multiple complications, including rare dermatologic manifestations such as PPK.This case illustrates the importance of thorough skin assessments in patients with diabetes, particularly those that have a history of sub-optimal diabetes control.A multidisciplinary approach, integrating dermatology, endocrinology and allied health services such as podiatry, is essential in managing diabetes-related complications, improving patient quality of life and preventing further complex manifestations.
SGDWOA: A Novel Approach in Whale Optimisation for Accurate Cell Classification in Oral Squamous Cell Carcinoma Using Machine Learning
Authors: Suresh-Pandit Anuradha , Dixit Vaibhav V. 
Published: January 2025

Oral squamous cell carcinoma (OSCC), a common head and neck cancer, is often unnoticed but can be identified early. Diagnosing this heterogeneous tumour requires extensive human experience, and artificial intelligence can help to improve diagnosis. This study used novel methodologies based on feature selection and classification in an attempt to obtain good findings for the early detection of OSCC. By using cutting-edge hybrid strategies to extract features and improve classification, this work seeks to bridge the gap among deep learning and machine learning procedures. Initially, preprocessing is done to address artifacts in the OSCC dataset. The first method uses SMOTE oversampling and feature scaling in conjunction with Resnet 50 and Efficientnet B5 models for feature extraction. In the second method, the best feature set is chosen using the Statistic gain Dynamic Remodelled Whale Optimization Algorithm (SDRWOA), and the Random Forest Classifier is then employed to classify cancer types into poor, moderate, and well categories. The finding shows that the proposed model beats the other classifiers by attaining the maximum overall accuracy, recall and F1-score of 98% and precision of 97.6%. In conclusion, the suggested approach advances the development of extremely precise and effective OSCC diagnosis techniques.
Evaluación de estilos de foresight en Colombia: adaptación y validación en español del foresight styles assessment
Authors: Contreras-Monroy Carlos Arturo , Osorio-Vera Francisco Javier , Serna-Mejía Cesar Augusto 
Published: January 2025

El Foresight es una competencia del liderazgo, que permite a los líderes organizacionales adoptar una perspectiva de futuro que facilita la formulación de una Visión Normativa (noción de trascendencia hacia el largo plazo de tiempo) para la toma de decisiones. La competencia se manifiesta cuando los líderes enfrentan cuestiones relacionadas con el futuro y sus decisiones estratégicas de tipo complejo y de largo plazo. Esta investigación tuvo como objetivo la adaptación y validación del instrumento Foresight Styles Assessment (FSA) a la idiosincrasia latinoamericana y en idioma español, quedando denominado como Evaluación de Estilos de Foresight (EEF) con el fin de que sea una herramienta confiable para medir la competencia del Foresight en los líderes de las organizaciones de habla hispana, en especial para Colombia, y evaluar sus propiedades psicométricas. El instrumento pasó por tres fases, la primera fue una adaptación cultural, la segunda fase fue su traducción asertiva al español, consolidando un instrumento en español de 23 ítems. La tercera fase fue la validación del instrumento con una muestra depurada de 118 individuos relacionados al programa de Extensionismo Tecnológico, aplicándoles el instrumento EEF de 26 ítems con respuesta tipo Likert el cual entregó un alfa de Cronbach de 0.981, mostrando un ajuste satisfactorio. Además, se utilizaron las técnicas estadísticas de Análisis Factorial (AF), el Análisis Factorial Confirmatorio (AFC) y el Modelado de Ecuaciones Estructurales (MEE); confirmando cuatro constructos o variables latentes (Framer/Enmarcador, Adapter/Adaptador, Tester/Experimentador y Reactor/Resistente), reduciendo las preguntas a 23 ítems para Colombia. El EEF es una herramienta útil en la de toma de decisiones por parte de los líderes que integran las organizaciones, permitiendo mejorar su visión, competitividad y perdurabilidad.
МЕТОДИКИ СТАНДАРТУ ISA-106 ДЛЯ АВТОМАТИЗАЦІЇ ПРОЦЕДУР ОПЕРАЦІЙ НЕПЕРЕРВНИХ ПРОЦЕСІВ
Authors: Пупена О. М. 
Published: January 2025

Анотація. Для неперервних виробництв характерною є складність виконання процедур запуску, зупинки, зміни продукту чи виходу з нештатних ситуацій. Це пов'язано з великою кількістю необхідний, часто ручних, дій, відсутністю достатнього досвіду у операторів, а тривалий їх час приводить до значних витрат. Авторитетна організація по стандартизації International Society of Automation у 2023-му році випустила стандарт ISA-106, мета якого передати кращі практики для автоматизації процедур. За досить тривалий час роботи комітету вийшло небагато просвітнього матеріалу щодо пояснення методик, а їх розуміння тісно пов'язано з іншими спорідненими стандартами. У той же час, відомими світовими інжиніринговими організаціями наводяться вагомі аргументи щодо його важливості. Після виходу стандарту, діяльність щодо висвітлення його концепцій у світі практично не спостерігається, в Україні такого матеріалу немає зовсім. У той же час, стандарт надає основу для автоматизації процедур через означення основних моделей, концепцій автоматизованого керування та опису процесів в життєвому циклі автоматизованих систем керування. Частина з цих моделей є спільними з зі спорідненими стандартами ISA-88/IEC-61512, ISA-95/IEC-62264, тим не менше є певні суперечності в них. Також є ідеологічні відмінності між ISA-88 та ISA-106, що робить впровадження останнього дещо складнішим та обмежує його можливості. Основні відмінності є в інтерпретації нижнього рівня фізичної моделі, концепції модуля у ISA-88 у порівнянні з концепцією процедури в ISA-106 та понятійному відношенні. Наразі необхідна розробка відповідного просвітнього матеріалу, методичного забезпечення та інструментарію, що спростить впровадження стандарту і відповідно матиме позитивний економічний ефект на підприємствах з неперервним виробництвом.
Distal radial access as an alternative to conventional radial access in coronary angiography and percutaneous coronary interventions
Authors: Korotkikh A. V. , Babunashvili A. M. , Kaledin A. L. , Akhramovich R. V. , Derkach V. V. , Portnov R. M. , Kartashov D. S. 
Published: January 2025

Aim. To evaluate immediate and medium-term (3 months) results of safety and effectiveness of distal versus proximal radial access for coronary interventions.Material and methods. An analysis of 776 patients of the prospective randomized TENDERA trial was performed: distal radial access (DRA) group — 1391 patients; proximal radial access (PRA) group — 385 patients. After excluding patients with failed primary access, the primary sample sizes decreased (DRA — 371, PRA — 382). Access-site crossover rate was statistically higher in the DRA group (5,1% and 0,8%, p<0,001). The primary endpoint was immediate (inhospital) or long-term radial artery (RA) thrombosis/occlusion. There were following secondary endpoints: 1 — composite endpoint including complications from the access artery; 2 — access parameters.Results. Significant differences were obtained for the primary endpoint: DRA 2,7% (n=10), PRA 6,8% (n=26), p=0,008. Distal RA occlusion with patent RA: DRA: 1,3% (n=5), PRA: 0 (n=0), p=0,023. The secondary composite point showed significant differences in the following groups of complications: BARC type I bleeding (DRA: 3,8% (n=14), PRA: 21,7% (n=83), p<0,001); hematoma >5 cm on day 1 (DRA: 10% (n=37), PRA: 25,9% (n=98), p<0,001); hematoma >5 cm on day 7 (DRA: 12,4% (n=45), PRA: 34,6% (n=132), p<0,001). The following access parameters showed significant differences: distal RA puncture time — 19,0 (8,0; 50), proximal RA puncture time — 13,5 (5,0; 29), p<0,001; introducer insertion by DRA 42,0 (26,0; 84,0), PRA 35,0 (23,0; 55,0), p<0,001; duration of access artery hemostasis (min): DRA 180,0 (120,0; 480,0), PRA 155,0 (115,0; 195,0), p<0,001. Duration of the procedure and fluoroscopy, radiation dose, and RA spasm in both groups did not have significant differences.Conclusion. In the TENDERA study, DRA demonstrated efficacy and safety in interventional coronary procedures compared to PRA in the mid-term follow-up period — significantly lower incidence of RA occlusions and local complications.
Prognostic significance of the novel START arterial stiffness index in patients with coronary artery disease after coronary artery bypass grafting
Authors: Sumin A. N. , Shcheglova A. V. , Barbarash O. L. 
Published: January 2025

Aim. To study the long-term prognostic value of the novel START vascular stiffness index in patients with coronary artery disease (CAD) after coronary artery bypass grafting (CABG).Material and methods. The study included 256 patients with CAD who underwent CABG at the Kemerovo Research Institute for Complex Issues of Cardiovascular Diseases. Before surgery, vascular stiffness was assessed using the haSTART cardio-ankle index. The mean follow-up period was 9,7±0,9 years. Two following study groups were formed: Group I — haSTART < the median (Me) index of 8,4 (haSTART <Me (n=118)); group II — haSTART ≥ the median (haSTART ≥Me, n=138). The prognostic value of haSTART was studied in relation to the following composite end point (CEP): death, non-fatal myocardial infarction, or stroke.Results. Patients in the haSTART ≥Me group were significantly older than in the haSTART <Me group (p<0,001). In both groups, men predominated (76,2%). During the follow-up period, all-cause death was significantly more common in the haSTART ≥Me group (34,1%) than in the haSTART <Me group (19,5%), p=0,009. Cardiovascular death was also more common in the haSTART ≥Me group than in the haSTART <Me group (23,2% vs 8,5%, p=0,001). In patients with haSTART ≥Ме, CEP was observed in 45,7% of cases, compared to patients with haSTART <Ме (30,5%), p=0,013. Among patients with fatal outcome, the prevalence of patients with haSTART ≥Ме values was higher than in the group of survivors (67,1% and 48,9%, p=0,009). Among patients with CEP — the detection rate of haSTART ≥Ме was 63,6%, which was significantly higher than in the group of survivors without cardiovascular events (47,8%, p=0,013). Kaplan-Meier curves revealed a better long-term prognosis in the haSTART <Me group to the haSTART ≥Me group (p>0,05).Conclusion. Evaluation of the haSTART stiffness index before CABG surgery may have prognostic value in the long-term follow-up period in patients with CAD.
Features of the atherosclerotic plaque microbiome in patients after carotid endarterectomy
Authors: Kolesova E. P. , Chernyavsky M. A. , Vanyurkin A. G. , Verkhovskaya E. V. , Zaykova E. K. , Kalinina O. V. , Sitkin S. I. , Maslyansky A. L. , Kvan V. V. , Vasilyeva E. Yu. , Yakovlev A. N. , Babenko A. Yu. , Konradi A. O. , Shlyakhto E. V. 
Published: January 2025

Aim. To study the microbiome of atherosclerotic plaque biopsies in patients who underwent carotid endarterectomy (CEA).Material and methods. In this study, the microbiota profile of 76 atherosclerotic plaque samples obtained during CEA was analyzed using high-throughput sequencing of 16S rRNA V4 region. The proportion of patients without restenosis included in the study was 20%. The median follow-up of patients was 1,9 years (range, 1,4-2,25).Results. Taxonomic analysis revealed that the plaque microbiome is characterized by a wide diversity of gram-negative bacteria, including bacteria that are widespread in the environment. Bacteria most represented in plaques belong to four following families: Caulobacteraceae, Rhizobiaceae, Sphingobacteriaceae and Weeksellaceae. Linear discriminant analysis Effect Size (LEfSe) revealed a significantly higher representation of the microbial marker OTU_21, belonging to the Sphingomonadaceae family, in the atherosclerotic plaque microbiome of patients with ≥50% restenosis and Cloacibacterium (OTU_67), belonging to the Weeksellaceae family, in patients with >70% restenosis.Conclusion. The obtained data emphasize the importance of studying the atherosclerotic plaque microbiome and suggest that microorganisms of various origins, including those that have not previously been considered as risk factors, can play a pathogenetic role in both atherogenesis and restenosis.
Evaluation of lipoprotein(a) — a novel cardiovascular risk factor in patients with atherosclerotic cardiovascular diseases receiving PCSK9-targeted therapy in Russian real-world practice
Authors: Sapina A. I. , Varlamova Yu. Yu. , Papyrina M. G. , Bezymyannyy A. S. , Kordzaya E. L. , Vasilyeva E. Yu. 
Published: January 2025

Aim. To evaluate the effect of PCSK9-targeted therapy on lipoprotein(a) (Lp(a)) levels in patients with atherosclerotic cardiovascular diseases who have not achieved the target low-density lipoprotein cholesterol (LDL-C) level (statins at maximum tolerated doses and/or ezetimibe).Material and methods. The study involved 3 Moscow medical facilities of the state healthcare system. The study included 50 people who received inclisiran therapy, 30 people — PCSK9 inhibitors (alirocumab, n=1; evolocumab, n=29). This analysis presents the results of Lp(a) level changes over 12-month inclisiran therapy. Lp(a) was determined by turbidimetry. Elevated Lp(a) level was defined as ≥50 mg/dL (125 nmol/L).Results. Normal Lp(a) levels were determined in 16 subjects (34,8%), moderate — in 9 subjects (19,6%), high — in 21 subjects (45,7%), and extremely high (>180 mg/dL) — in 8 subjects (17,4%). Inclisiran therapy was associated with a significant (p<0,001) decrease in both LDL-C and Lp(a) levels by 52% and 54,7%, respectively. During therapy, normal Lp(a) levels remained within baseline values. In almost half of the cases with moderate Lp(a) values, its concentration decreased to normal values, and in cases with elevated Lp(a), its level decreased in 9 out of 10 patients. The proportion of patients in the group with Lp(a) levels <30 mg/dl increased from 35% to 41%. No patient had extreme values by the end of the study.Conclusion. Lp(a) assessment may be appropriate with ongoing PSCK9-targeted therapy. Diagnosis of hyper-Lp(a) is important for early intensive combination lipid-lowering therapy and modification of risk factors in order to reduce the risk of cardiovascular diseases.