bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of embolotherapy for the treatment of pelvic congestion syndrome: A systematic review
Authors: Hanna Joseph , Bruinsma Joshua , Temperley Hugo C. , Fernando Dhanushke , O’Sullivan Niall , Hanna Mark , Brennan Ian , Ponosh Stefan 
Published: January 2024

AbstractPelvic congestion syndrome (PCS) poses a significant health, diagnostic, and economic challenges. Transcatheter embolisation has emerged as a promising treatment for PCS. A systematic review was performed in order to assess the safety and efficacy of transcatheter embolisation in the treatment of PCS. A systematic search of electronic databases was performed using ‘PubMed’, ‘Embase’, ‘Medline (OVID)’, and ‘Web of Science’, for articles pertaining to efficacy of embolotherapy for the treatment of pelvic congestion syndrome. A total of 25 studies were included in this systematic review with a combined total of 2038 patients. All patients included were female with a mean average age of 37.65 (31–51). Of the 25 studies, 18/25 studies reported pre- and post-procedural pelvic pain outcomes using a visual analogue scale (VAS). All studies showed a reduction in VAS post-procedure. Transcatheter embolisation had a high technical success rate (94%) and an overall complication rate of 9.0%, of which 10.4% were major and 89.6% were minor. Fifteen out of 19 (78.9%) major complications required a subsequent intervention. Transcatheter embolisation using various techniques is effective and safe in treating PCS. A low quality of evidence limits the currently available literature; however, embolisation has shown to improve symptoms in the majority of patients with low complication rates and recurrence rates.
How Will Our Practice Change After the CLEAR Outcomes Trial?
Authors: Abrahams Timothy , Nelson Adam J. , Nicholls Stephen J. 
Published: January 2024

Abstract
Purpose of Review
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-C). The purpose of this review is to provide the background for development of bempedoic acid, findings from clinical trials and to discuss clinical implications.

Recent Findings
Bempedoic acid inhibits ATP citrate lyase within the liver and reduces cholesterol synthesis, with the potential to avoid muscle symptoms experienced by patients treated with statins. Early clinical studies demonstrated that administration of bempedoic acid resulted in lowering of LDL-C by 20–30% as monotherapy and by 40–50% when combined with ezetimibe, in addition to lowering of high sensitivity C-reactive protein by 20–30%. The CLEAR Outcomes trial of high cardiovascular risk patients, with elevated LDL-C levels and either unable or unwilling to take statins demonstrated that bempedoic acid reduced the rate of major adverse cardiovascular events. A greater incidence of elevation of hepatic transaminase and creatinine, gout, and cholelithiasis were consistently observed in bempedoic acid–treated patients.

Summary
Bempedoic acid presents an additional therapeutic option to achieve more effective lowering of LDL-C levels and reduction in cardiovascular risk.
Reflection of Physical Descriptive Parameters as Functional Phenes on Olive Oil Cross-border Mapping
Authors: Fathy Hoda , Sfatee Mahmoud A. , Omar Abdallah , Aboushoer Mohamed 
Published: January 2024

AbstractThe medicinal and nutritional benefits of olive oil are reflected in its extensive incorporation in many cultures in food and pharmaceutical products. This study suggests the use of colour-based models, viscosity and refractive index as parametric attributes to experiment and track down the authenticity of the oil through image analysis and accurate determination of refractive index and viscosity of oils from different regions.The combination of RGB measurement and chemometric methods (PCA, PCA-class) of olive oil samples collected from distinctive areas (Tunisia, Libya and Egypt) enabled the differentiation of olive oil samples per region of cultivation and was found to be accurate, precise (R2X 0.997) and successful in detecting the accuracy of the labelled information (traceability determination, freshness, purity, date and storage conditions) and could be extrapolated to study the position of harvested areas. The results also revealed a perfect discrimination between the defined categories based on the origin and age after performing the Orthogonal Projection to Latent Structures-Discriminant Analysis (OPLS-DA) on the visible spectra of the samples reaching 90% of correct classifications.
Thermal Comfort Properties of 100% Cashmere Knitted Fabrics
Authors: Dolanbay Dogan Selma , Kılınc Nurgül 
Published: January 2024

AbstractThe purpose of this research is to investigate the effects of knitting type (plain, rib, purl), knitting tightness (three different loop lengths), and plied-yarn (single-ply, two-ply and three-ply) on the thermal comfort properties of cashmere knitted fabrics. Thermal comfort properties of the sample fabrics were measured using Alambeta, Permetest, Textest 3300. Subsequently, the results were statistically evaluated with SPSS program. The findings of this research revealed that the knitting type, knitting tightness and plied-yarn usage significantly affect certain thermal comfort properties of cashmere knitted fabrics. Specifically, the plain knitted fabric exhibits the lowest thermal resistance value and the highest relative water vapor permeability value. The loose knitted fabric demonstrates the highest air permeability, while the fabric knitted with single-ply yarn has the lowest thermal conductivity and thermal resistance values, as well as the highest relative water vapor permeability and air permeability values.
Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex
Authors: Shi Yuhan , Yan Jingjing , Xu Xiaohong , Qiu Zilong 
Published: January 2024

AbstractThe retrosplenial cortex has been implicated in processing sensory information and spatial learning, with abnormal neural activity reported in association with psychedelics and in mouse and non-human primate models of autism spectrum disorders (ASDs). The direct role of the retrosplenial cortex in regulating social behaviors remains unclear. In this work, we reveal that neural activity in the retrosplenial agranular cortex (RSA), a subregion of the retrosplenial cortex, is initially activated, then quickly suppressed upon social contact. This up-down phase of RSA neurons is crucial for normal social behaviors. Parvalbumin-positive GABAergic neurons in the hippocampal CA1 region were found to send inhibitory projections to the RSA. Blocking these CA1-RSA inhibitory inputs significantly impaired social behavior. Notably, enhancing the CA1-RSA inhibitory input rescued the social behavior defects in an ASD mouse model. This work suggests a neural mechanism for the salience processing of social behavior and identifies a potential target for ASD intervention using neural modulation approaches.
Exploring the frontiers: tumor immune microenvironment and immunotherapy in head and neck squamous cell carcinoma
Authors: Liu Shaokun , Wang Ru , Fang Jugao 
Published: January 2024

AbstractThe global prevalence of head and neck malignancies positions them as the sixth most common form of cancer, with the head and neck squamous cell carcinoma (HNSCC) representing the predominant histological subtype. Despite advancements in multidisciplinary approaches and molecular targeted therapies, the therapeutic outcomes for HNSCC have only marginally improved, particularly in cases of recurrent or metastatic HNSCC (R/MHNSCC). This situation underscores the critical necessity for the development of innovative therapeutic strategies. Such strategies are essential not only to enhance the efficacy of HNSCC treatment but also to minimize the incidence of associated complications, thus improving overall patient prognosis. Cancer immunotherapy represents a cutting-edge cancer treatment that leverages the immune system for targeting and destroying cancer cells. It's applied to multiple cancers, including melanoma and lung cancer, offering precision, adaptability, and the potential for long-lasting remission through immune memory. It is observed that while HNSCC patients responsive to immunotherapy often experience prolonged therapeutic benefits, only a limited subset demonstrates such responsiveness. Additionally, significant clinical challenges remain, including the development of resistance to immunotherapy. The biological characteristics, dynamic inhibitory changes, and heterogeneity of the tumor microenvironment (TME) in HNSCC play critical roles in its pathogenesis, immune evasion, and therapeutic resistance. This review aims to elucidate the functions and mechanisms of anti-tumor immune cells and extracellular components within the HNSCC TME. It also introduces several immunosuppressive agents commonly utilized in HNSCC immunotherapy, examines factors influencing the effectiveness of these treatments, and provides a comprehensive summary of immunotherapeutic strategies relevant to HNSCC.
Evaluation of a weather forecasting model and HEC-HMS for flood forecasting: case study of Talesh catchment
Authors: Goodarzi Mohammad Reza , Poorattar Mohammad Javad , Vazirian Majid , Talebi Ali 
Published: January 2024

AbstractReports demonstrate that floods are among the most prevalent and deadliest natural disasters affecting 520 million people annually. The present study seeks to evaluate flood forecasting using the weather research and forecasting (WRF) model and the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) model. To this end, WRF and HEC-HMS were calibrated by comparing their results with the data observed at measuring stations. Then, the output rainfall data of the WRF model were implemented by the calibrated HEC-HMS model and were examined using the statistical indices, which were revealed to be 4.13, 3.42, and 2.67 for the flow volume and 6.2, 2.46, and 5.11 for the peak flow, suggesting the accurate performance of WRF model alongside HEC-HMS in the Talesh catchment.
Hydrochemical assessment of groundwater using multivariate statistical methods and water quality indices (WQIs)
Authors: Hamma Bellal , Alodah Abdullah , Bouaicha Foued , Bekkouche Mohamed Faouzi , Barkat Ayoub , Hussein Enas E. 
Published: January 2024

AbstractGroundwater quality assessment is crucial for the sustainable management of water resources in arid regions, where groundwater is the primary source of water supply and increasing demand raises concerns. The study area in Southwest Algeria relies heavily on groundwater as a source of water supply, and the increasing demand for freshwater raises concerns about the quality of groundwater. To assess the hydrochemical characteristics and water quality of groundwater in the Ain Sefra region, multivariate statistical methods, geochemical modeling and water quality indices were employed. The study revealed that the groundwater samples could be classified into four water groups using hierarchical cluster analysis Q mode (HCA), namely Ca–Mg–HCO3, Ca–Mg–Cl–SO4, Ca–SO4 and Na–Cl. Factor analysis was used to identify the main factors controlling the study area’s hydrochemical processes. The results indicated that water–rock interaction, reverse ion exchange and anthropogenic pollution were the main hydrochemical processes affecting groundwater chemistry. The water quality index indicated that the groundwater was suitable for human consumption, with only 2.32% of the samples being unsuitable. Additionally, the groundwater was suitable for agricultural use, but salinity control was necessary. The saturation index values showed that the groundwater was supersaturated with aragonite, calcite, dolomite, anhydrite and gypsum, and undersaturated with halite. Ca-smectite, Mg-smectite and kaolinite were identified as the primary processes controlling the chemical composition of groundwater. The application of multivariate statistical methods, geochemical modeling and water quality indices provided a comprehensive understanding of the hydrochemical characteristics and water quality of groundwater in the Ain Sefra region. The findings of the study can serve as a useful basis for future studies on groundwater quality assessment in the region.
Seasonal prevalence of the invasive rusty-spotted longhorn beetle, Apriona swainsoni (Coleoptera: Cerambycidae), adults in Fukushima Prefecture, Japan
Authors: Anzai Yukari , Sunamura Eiriki , Tamura Shigeaki , Shoda-Kagaya Etsuko 
Published: January 2024

AbstractInvasive longhorn beetles are serious pests of tree stands worldwide. The rusty-spotted longhorn beetle, Apriona swainsoni (Hope) (Coleoptera: Cerambycidae: Lamiinae), is native to continental Asia, where it is a significant pest of legume trees. Its invasion into non-native ranges and damage to the local legume tree, Maackia amurensis, were first reported from Fukushima Prefecture, Japan, in 2021. This study investigated the biology of A. swainsoni in relation to adult emergence in Japan. Preliminary observations confirmed that A. swainsoni larvae create planned emergence holes on the host surface in late May. By exploiting these planned emergence holes, the adult emergence period was investigated in a field promenade of M. amurensis during the summer of 2022 and 2023. The researchers plugged the holes and recorded plug removal, resulting in the observation of 60 and 227 putative emergence events in respective years, with the majority occurring in early to mid-July. Further, during the summer of 2022, a periodic field survey of adult emergence was conducted, obtaining eight adults. Furthermore, a supplementary survey using infested logs maintained in a field cage demonstrated that the emergence period does not differ between sexes and the male-to-female ratio is one:one. Our results suggest that control efforts to suppress A. swainsoni adults in the field, such as insecticide spraying, should be prioritized in the relatively short, peak emergence period. This work indicates that the plug survey is useful for detecting the emergence period.
Investigation of a Photovoltaic–Thermal Solar Dryer System with Double-Pass Solar Air Collectors and Absorber Surfaces Enhanced with Graphene Nanoparticles
Authors: Öztürk Murat , Yüksel Coşkun , Çiftçi Erdem 
Published: January 2024

AbstractAs a result of increasing energy demand, seeking eco-friendly and sustainable energy resources increases the interest in renewable energy, specifically solar energy. In this study, a novel photovoltaic–thermal solar dryer system with double-pass solar air collectors and nano-enhanced absorber surface was developed, and its performance was experimentally investigated. Initially, a double-pass solar dryer (DPSD) with an absorber surface of flexible aluminum ducts coated with black matte paint was produced. Then, a double-pass solar dryer (NDPSD) consisting of flexible aluminum ducts coated with graphene and black paint was designed. These two systems were experimentally and simultaneously examined, and parameters such as energy and exergy efficiency, drying rate, and moisture ratio, which are the performance indicators of solar air collectors and the drying process, were analyzed. The sustainability parameters were also considered as a part of the analysis. The mean thermal efficiency of the solar air collectors for DPSD and NDPSD was calculated as 57.23 and 73.36%, respectively, where the airflow rates were measured as 0.024 and 0.017 kg/s. Furthermore, under the same airflow rate conditions, while the mean exergy efficiency of the collector was 27.77% for NDPSD, it was calculated as 16.64% for DPSD. Moreover, exergy efficiencies of the drying chamber varied between 27.35% and 82.20% for NDPSD and between 21.03 and 81.25% for DPSD, under the airflow rates of 0.012–0.016 kg/s conditions, respectively.
Flucloxacillin and cefazolin for treatment of Staphylococcus aureus bloodstream infection
Authors: Schmidt-Hellerau Kirsten , Breuninger Marianne , Kessel Johanna , Vehreschild Maria J. G. T. , Paul Gregor , Reusch Jomana , Jung Norma , Hellmich Martin , Fätkenheuer Gerd 
Published: January 2024

Abstract
Purpose
Antistaphylococcal penicillins and cefazolin have been used as first line therapy in Methicillin-susceptible Staphylococcus aureus bloodstream infection. While efficacy of both regimens seems to be similar, the compounds may differ with regard to tolerability. This study aims to describe the clinical use of cefazolin and flucloxacillin, focussing on discontinuation or change of anti-infective agent due to adverse events.

Methods
This observational prospective study was conducted at two German tertiary care centres with an internal recommendation of flucloxacillin for MSSA-BSI in one, and of cefazolin in the other centre. Adverse events were registered weekly under treatment and at a 90-day follow-up. Descriptive analysis was complemented by a propensity score analysis comparing adverse events (stratified rank-based test applied to the sum of Common Terminology Criteria for adverse events ratings per patient).

Results
Of 71 patients included, therapy was initiated with flucloxacillin in 56 (79%), and with cefazolin in 15 (21%). The propensity score analysis indicates a statistically significant difference concerning the severity of adverse events between the treatment groups in favour of cefazolin (p = 0.019). Adverse events led to discontinuation of flucloxacillin in 7 individuals (13% of all patients receiving flucloxacillin). Clinical outcome was not different among treatment groups.

Conclusion
Using cefazolin rather than flucloxacillin as a first line agent for treatment of MSSA-BSI is supported by these clinical data.
Physical activity trajectories and their associations with health outcomes in older adults with mild cognitive impairment or dementia: a national cohort study
Authors: Chen Yiping , Li Yao , Li Wei , Tian Yuling , Yang Hui 
Published: January 2024

Abstract
Background
Physical activity (PA) is a promising non-pharmacological intervention for this population. However, few studies have investigated their PA trajectories, influencing factors, and their relationship with health outcomes.

Aims
The aim was to identify latent trajectories in PA and their determinants in older adults with mild cognitive impairment (MCI) or dementia, as well as to assess the associations between PA trajectories and health outcomes based on the capability-opportunity-motivation behavior model.

Methods
This is a cohort study. Data were obtained from a national cohort study and included participants aged 60 years and older with MCI or dementia. PA trajectories were identified using group-based trajectory modelling. Multinomial logistic regression was conducted to identify the predictors of PA trajectories. Linear regression models were used to assess the associations between PA trajectories and health outcomes. This study adhered to the STROBE checklist for reporting.

Results
Three distinct PA trajectories were identified: high-decreasing and rebound class (9.34%), moderate-decreasing class (10.31%), and low-increasing class (80.34%). The logistic regression showed that age, sex, education level, body mass index, residence, depressive symptoms, mobility activities of daily life score, frequency of social activities score were PA predictors. Adjusting for sociodemographic variables, only the high-decreasing and rebound class remained significantly associated with worse self-rated health.

Discussion
This study revealed three PA trajectories among older adults with MCI/dementia. Besides sociodemographic variables, addressing physical function and mental health, providing social support are vital for promoting PA in this population.
Weighted Sobolev Type Inequalities in a Smooth Metric Measure Space
Authors: Wang Pengyan , Chang Huiting 
Published: January 2024

Abstract
In this paper, we obtain weighted Sobolev type inequalities with explicit constants that extend the inequalities obtained by Guo et al. (Math Res Lett 28(5):1419–1439, 2021) in the Riemannian setting. As an application, we prove some new logarithmic Sobolev type inequalities in some smooth metric measure spaces.
When (and how) ideas become arguments: the regulation of party donations in Germany
Authors: Koß Michael 
Published: January 2024

Abstract
This article aims to explain the deviant German case of an early and comprehensive regulation of party donations (combining a high level of transparency and incentives for small donations). Given the limited explanatory power of economic and institutional factors, the article emphasises the causal role of ideas for a policy stabilisation which occurred after 1993. A process-tracing analysis suggests that the 1983–1993 reform period was characterised by a conflict of ideas. During this conflict, ideas regarding undisclosed donations as an anti-democratic interference with democratic political competition came to prevail over ideas regarding all donations as a necessary condition for democratic competition irrespective of their regulation. The key actors in this conflict were, on the one hand, the new Green party which resuscitated the idea of donations being potentially anti-democratic and, on the other hand, the Constitutional Court which ultimately endorsed this ideational legacy promoted by the Greens. After 1993, donations in Germany came to be accepted as a necessary evil whose anti-democratic potential had to be limited by transparency obligations and incentives for small donations. The findings presented here suggest that policymakers need to link attempts to regulate party donations to ideational legacies (if available) to successfully tackle political corruption.
Barriers and facilitators to consuming pulses: a qualitative exploration including effects of trying recipes at home
Authors: Whittall B. , Warwick S. M. , Jackson M. , Appleton K. M. 
Published: January 2024

Abstract
Pulses are a healthy, sustainable, low cost food, but consumption levels are low for a variety of reasons, including practical and cooking concerns. This work aimed to explore barriers and facilitators towards pulse consumption and increasing consumption, and the potential value of cooking suggestions and recipes for changing these perceptions. Two qualitative studies were undertaken. In Study 1, 21 participants (10 males, 11 females, of a range of ages, cooking responsibilities, and experiences with pulses) were interviewed both before and after receiving cooking suggestions and recipes. In Study 2, 12 participants (2 males, 10 females, as above) were interviewed once after trying recipes. Interviews were audio-recorded, transcribed, and analysed using thematic analysis. Seven themes described barriers and facilitators towards pulse consumption: ‘Enjoyment and Sensory properties’; ‘Benefits and Recommendations’; ‘Practical Concerns’; ‘Cooking Concerns’; ‘Compatibility with current diet’; ‘Personal Influences’; and ‘External Influences’. Some similar themes also referred to increasing consumption: ‘Willingness’; ‘Awareness, Knowledge of Benefits’; ‘Knowledge of Cooking and Practical Concerns’; and ‘Compatibility with current diet’. Cooking suggestions and recipe use resulted in themes on ‘Awareness’; ‘Willingness, Trying New Things’; ‘Small Changes’; and facilitators associated with ‘Enjoyment, Sensory Properties, Practical Concerns, Benefits’ and ‘Knowledge, Cooking Ideas and Confidence, Incorporation, Cooking Solutions’. Barriers related to ‘Risk and Preconceptions’; ‘Awareness, but’ inaction and additional considerations were also found. Our findings demonstrate a positive role for pulse consumption for increased experience, familiarity, and confidence with preparing, cooking, and consuming these healthy and sustainable foods.