bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of an Innovative Crowdsourced Resident Procedure Team Model to Improve Bedside Procedural Proficiency in the Inpatient Setting
Authors: Ilagan-Ying Ysabel C. , Cotter Robert , Su Chang , Rodwin Benjamin A. , Huston John C. 
Published: October 2023

Background Bedside procedures are a necessary skill for many residents. Practice changes, including the discontinuation of a minimum number of procedures required by the American Board of Internal Medicine, may have resulted in decreased incentive for residents to seek procedural opportunities.
Objective To improve residents’ procedural output and confidence in abdominal paracentesis, arterial and central venous line placement, nasogastric intubation, and ultrasound-guided peripheral intravenous catheter insertions (USPIV).
Methods A novel Resident Procedure Team (RPT) model was created using crowdsourced proficient (having completed ≥5 procedures) near-peers in combination with peer-led USPIV simulation workshops to increase the number of supervising residents available. Procedure logs and the number of residents who became qualified to perform and supervise procedures were tracked from July 2018 to June 2022 and compared before and after the implementation of the RPT in July 2020.
Results Implementing the novel RPT model significantly increased the number of procedures performed (1875 procedures post-RPT vs 1292 pre-RPT; P=.02). Abdominal paracentesis increased from 411 to 482 (17.3%), central venous line placement increased from 344 to 401 (16.6%), USPIV increased from 318 to 389 (22.3%), arterial line placement increased from 189 to 360 (90.5%), and nasogastric intubation increased from 30 to 243 (710.0%). Resident confidence levels increased significantly after RPT-led USPIV workshops (P&lt;.05 for all).
Conclusions Implementation of a novel, crowdsourced, resident-led procedure team and peer-led USPIV workshops helped increase the number of procedures performed by residents.
Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: a meta-analysis
Authors: Wang Pengcheng , Liao Jiadan 
Published: October 2023

Background: The role of interleukin-12(IL-12) gene +1188A/C polymorphism has been indicated in the progression of tuberculosis(TB). Nevertheless, the outcomes remain controversial.
Objectives: This meta-analysis focused on examining the association between IL-12 +1188A/C polymorphism and TB.
Methods: EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects model was utilized to calculate the combined odds ratios (ORs) as well as corresponding 95% confidenceintervals (CIs).
Results: A total of 9 related articles were discovered. The result of meta-analysis showed that IL-12 +1188A/C polymorphism did not show significant correlation with TB risk among the total population (C vs A: OR =0.66, 95% CI=0.41-1.05; AC vs AA: OR = 1.28, 95% CI =0.90-1.82; CC vs AA: OR =0.95, 95% CI=0.80-1.14; recessive model: OR =1.00, 95% CI = 0.75-1.34; dominant model: OR =1.07, 95% CI =0.94-1.21). As discovered from subgroup analyses based on race and HWE, this polymorphism did not show relationship with TB risk.
Conclusion: The present findings indicated that IL-12 +1188A/C polymorphism was not related to the risk of TB.
Keywords: IL-12; tuberculosis; meta-analysis.
Antibody response to pneumococcal conjugate vaccine 10 among Nigerian children under 5 years
Authors: A Udah Chidinma , U Iregbu Francis , E Ekanem Emmanuel 
Published: October 2023

Introduction: Invasive pneumococcal diseases have been a major contributor to childhood mortality, particularly in the developingworld and pneumococcal vaccines were introduced to reduce the burden. The Pneumococcal Conjugate Vaccine 10 (PCV 10) was incorporated into the Nigerian National Programme on Immunization (NPI) in 2014 to reduce the incidence of childhood pneumococcal infections. This study was done to determine the immunogenicity of the vaccine in our clime.
Methodology: This cross-sectional study was carried out between September 2019 and January 2020 at the Children Outpatient Clinic of the Federal Medical Center, Owerri, Nigeria. Two hundred and forty five children between the ages of 20 weeks and 59 months, who had received three doses of Pneumococcal Conjugate Vaccine 10 (PCV 10) at 6, 10 and 14 weeks according to the NPI schedule, were recruited into the study. The anti-pneumococcal PCV 10 IgG concentration was determined using Human Anti-Pneumococcal CPS 10 IgG vaccine ELISA Kit ®. Simple proportions, means and median (as appropriate) were used to analyse the data. Kruskal Wallis test and Spearman’s correlation were done to test association. Significance was set as p< 0.05.
Results: The mean anti-pneumococcal IgG concentration was 11.01±1.23 IU/ml and all the study participants formed protective levels of anti-pneumococcal IgG. There was a slight positive correlation between antibody response and age (r=0.13, p=0.04), and the antibody response was slightly more in males than females.
Conclusion: All the children under the age of five years who had received PCV 10 at 6, 10 and 14 weeks of age, who participated in this study formed protective levels of antibodies to the vaccine. Antibody levels increased slightly with age. The PCV 10 currently used in the Nigerian programme is sufficiently antigenic and a downward trend in pneumococcal diseases should soon be noticeable.
Keywords: Pneumococcal conjugate vaccine; antibody; children; Nigeria.
Expression of miR-152 in cervical cancer and its influence on cisplatin resistance
Authors: Wu Jun , Chi Xiaoping , Yang Qian , Li Jinxiao 
Published: October 2023

Background: Cervical cancer has a high mortality rate.
Aim: We aimed to study the expression of micro ribonucleic acid 152 (miR-152) in cervical cancer and its influence on cisplatin(DDP) resistance.
Methodology: Cervical cancer Hela cells were divided into control, DDP, DDP + mimic nc and DDP + miR-152 mimic groups.
Results: DDP, DDP + mimic nc and DDP + miR-152 mimic groups had lower cell survival rate, smaller number of single clones and cells penetrating the membrane, and higher apoptosis rate and miR-152 expression than those of the control group (P<0.05). Compared with DDP and DDP + mimic nc groups, the cell survival rate, number of single clones and number of cells penetrating the membrane significantly decreased, while the apoptosis rate and miR-152 expression increased in the DDP + miR-152 mimic group (P<0.05). ERBB3 was a downstream target gene of miR-152. Hela cells transfected with miR-152 mimic had lower protein expressions of Snail, ERBB3, Akt2, p-Akt and c-myc than those of NC cells (P<0.05).
Conclusion: MiR-152 suppresses the proliferation, migration and infiltration of cervical cancer cells and reduces their resistanceto DDP chemotherapy by inhibiting the expressions of proteins in the ERBB3/Akt/c-myc and ERBB3/Akt/Snail pathways.
Keywords: miR-152; cervical cancer; cisplatin; drug resistance.
Boosting COVID-19 vaccine inoculation and booster shots: a systematic review and meta-analysis of factors that influence coronavirus vaccine uptake in practice
Authors: Adusei-Mensah Frank , Michael Isiozor Nzechukwu , Lekpa Kingdom David , Jeff Oduro Kennedy , John Okolie Chukwuma 
Published: October 2023

Introduction: Vaccines alone do not control pandemics, but vaccinations. The hope of COVID-19 pandemic control is hinged on vaccinations and other public health measures. This systematic review/meta-analysis (SR/MA) investigated the factors that inform coronavirus vaccine uptake globally in an attempt to improve COVID-19 immunization.
Method: The PRISMA 2020 methodology was used for this review. A total of 2902 articles were identified from electronic databases and other sources. After screening, 33 articles were included in the review and quantitative meta-analysis. Comprehensive meta-analysis software version 3 was used for the meta-analysis.
Results: We observed that vaccine effectiveness, side effects and the proportion of acquaintances vaccinated significantly influencedrespondents’ COVID-19 immunization decision. Also, associations of vaccine effectiveness, smaller risks to serious side effects, free and voluntary vaccinations and fewer vaccine doses, and longer duration to wanning were observed. We also observed variations in vaccine hesitancy trends in studies carried out in Asia, Europe, America, and Africa.
Conclusion: Wanning and acquaintance’s vaccination status as factors to vaccination are insights the present paper is bringing to the limelight. Health promotion and COVID-19 vaccination planning are crucial for enhancing vaccine uptake.
Keywords: Vaccination; vaccine hesitancy; coronavirus; pandemic; herd immunity; immunization.
Overexpression of C19orf48 correlates with poor prognosis in breast cancer
Authors: Guo Jia , Hui Beina , Gong Tuotuo , Zhao Xu , Li Jing 
Published: October 2023

As one of the most commonly diagnosed cancers in women around the world, breast cancer has been detailed studied. This study aimed to identify the expression of c19orf48 in several kinds of cancers including liver, lung and breast cancers etc. The driving factors behind it were analysed and it found that the amplification of c19orf48 may relate with the elevated expression. At the same time, the correlation between the expression of it and the survival time in breast cancer patients was explored. It was found that the c19orf48 expression at transcriptional level elevated in breast cancer tissue samples compared with the normal. It was inferred that the c19orf48 play its oncogenic role in development of breast cancer by involving in cell-cycle related biological process. In conclusion, c19orf48 may be a useful and predictive biomarker for the prognosis of breast cancer patients. To the best of our knowledge, this is the first report describing the expression of c19orf48, the potential driving factor led to this and its effect.
Keywords: Breast cancer; c19orf48; Predictive biomarker.
Prediction of recurrence of early gastric carcinoma after endoscopic submucosal dissection
Authors: Xu Hongjing , Yang Xiaojun , Lu Ying , Wang Shiming 
Published: October 2023

Background: The aim of this retrospective study was to predict the post-endoscopic submucosal dissection (ESD) recurrence risk of early gastric carcinoma (EGC) using a nomogram model, and to provide valuable evidence for preventing the recurrence.
Methods: The patients with EGC receiving ESD between March 2010 and February 2018 were enrolled. They were followed up once every three months after ESD. At the end of follow-up, they were assigned into recurrence and non-recurrence groups. The independent risk factors for post-ESD recurrence were identified using Cox regression analysis. A nomogram prediction model was established, and its predictive efficiency was assessed by plotting receiver operating characteristic (ROC) curve.
Results: Helicobacter pylori (HP) infection, number of positive lymph nodes >3 and a large amount of intraoperative hemorrhage were risk factors for post-ESD recurrence. According to multivariate Cox regression analysis, HP infection and number of positive lymph nodes >3 were independent predictors. The nomogram model had a good fitting effect, and the area under ROC curve was 0.933 (95% confidence interval: 0.919-0.947), suggesting a high predictive efficiency.
Conclusion: Positive lymph nodes and HP infection are closely correlated with the recurrence risk after ESD in EGC patients. The established model is a quantitative tool for predicting recurrence to improve the prognosis.
Keywords: Endoscopy; gastric carcinoma; nomogram model; recurrence; submucosal dissection.
Advice for smokers in smoking cessation clinic: a review
Authors: Yu Xuechan , Wang Meihua , Cen Jie , Ye Mianzhi , Li Sha , Wang Younuo , Su Qingwen , Chen Hui , Xu Ruyi , Zhang Shuya , Wang Shanshan , Yu Yiming , Deng Zaichun , Chen Zhongbo 
Published: October 2023

Background: Tobacco dependence has become a global public health concern. We chose to investigate the modifiable factors and motivations during the period of smoking cessation based on the mechanism of nicotine addiction.
Methods: We selected emotion, sleep, alcohol, caffeine beverages, mental activities after dinner, exercise and CYP2A6 genotype as influencing factors, and provided corresponding recommendations for smokers based on these factors. Based on these characteristics, we reviewed literature and summarized the relationship between these factors and nicotine dependence or smoking.
Results: Different emotion, sleep deficiency, caffeine intake, alcohol consumption, mental activities after dinner, physical exercises and CYP2A6 genotype have an effect on daily smoking and nicotine dependence.
Conclusion: These suggestions related literature-derived factors may increase the success rate of smoking cessation.
Keywords: Tobacco dependence; smoking cessation; risk factors; advice; addiction.
Effects of right stellate ganglion block combined with topical anesthesia on heart rate variability in awake patients receiving tracheal intubation
Authors: Bai Liping , Hao Weihong , Zhang Chunmin , Guan Zhiming 
Published: October 2023

Objective: General anesthesia is commonly performed with tracheal intubation. We aimed to evaluate the effects of right stellateganglion block combined with topical anesthesia on the heart rate variability in awake patients receiving tracheal intubation.
Methods: A total of 120 eligible patients were equally divided into observation and control groups using a random number table. The observation group underwent right stellate ganglion block combined with topical anesthesia. The excellent and good rate of anesthesia, indicators of vital signs and heart rate variability, incidence rate of adverse reactions, success rate and time consumption of tracheal intubation, postoperative resuscitation and cognitive function score of the two groups were compared.
Results: The systolic pressure, diastolic pressure and heart rate significantly increased in both groups during tracheal intubationcompared with those before tracheal intubation, which they were lower in the observation group than those in the control group during tracheal intubation (P<0.05). Low-frequency power, ratio of low-frequency power to high-frequency power and heart rate variability index significantly decreased in both groups during tracheal intubation compared with those before tracheal intubation (P<0.05).
Conclusion: Right stellate ganglion block combined with topical anesthesia can work well for awake patients during trachealintubation.
Keywords: Anesthetics, topical; block; heart rate; intubation, intratracheal; stellate ganglion.
Visual outcome after small incision cataract surgery of patients in a Kenyan Hospital contributors
Authors: Kipkemboi Rono Julius , Nirghin Urvashni 
Published: October 2023

Background: The visual outcome and the effect of cataract surgery on existent and surgically induced refractive errors are a concern of interest that the eye care expert must deal with.
Objectives: The aim of the study was to investigate the visual outcome after small incision cataract surgery of patients in a Kenyan hospital.
Methods: A descriptive retrospective study covering 3 years (2015 to 2017). Total of 1104 files of patients aged > 50 years who had undergone small incision cataract surgery at Sabatia eye hospital were purposively selected. Information on demographics, clinical aspects and outcome was collected using a ministry of health structured form. Statistical package for social sciences version 24 was used to analyse the data.
Results: Of the 1104 patients, 55% (n=606) were females. The mean age of patients was 70.6 ± 9.8 years. Most patients were from the hospital neighbourhood. Visual acuity improved by 38.9%, 28.9%, 19.8% and 11.5% in patients aged 50-59, 60-69, 70-79, and 80-89 years old, respectively.
Conclusion: Small incision cataract surgery improved visual acuity in all patients’ groups, but the outcome is influenced by age, refractive error particularly astigmatism.
Keywords: Small incision cataract surgery; visual outcome; refractive errors.
Exploring the barriers and facilitators towards physical activity among church members in Lagos, Nigeria: a qualitative study
Authors: Ololade Odukoya Oluwakemi , Olukemi Odediran Omoladun , R Rogers Charles , Ogunsola Folasade , S Okuyemi Kolawole 
Published: October 2023

Background: Physical inactivity is substantially linked to the rise in the global burden of non-communicable diseases. Faithbasedorganizations are recognized as potential partners for sustainable health interventions.
Objective: This study aims to explore the facilitators and barriers towards physical activity among adult church members in Lagos, Nigeria.
Methods: Sixteen focus group discussions (n-163) were conducted among adult male and female church members in twelve Anglican churches. The discussions were audio-taped, transcribed verbatim and analysed along with the field notes for themes using sequential approach with the aid of the Dedoose® software.
Results: Individual facilitators of PA included self-discipline, and personal habits. Individual barriers were laziness, ill-health, fear of injury and pre-existing health conditions. Organizational facilitators included biblical verses promoting PA, while deterring factors were lack of safe spaces for PA and poor knowledge among church leadership. The community-level facilitators included pro-physical activity cultural practices, while the prevailing practice hiring house-helps, high costs of gym membership and gender norms discouraging men from participating in household chores served as deterring community-level factors. Environmental facilitators were the availability of safe spaces for PA while deterring factors were city living and high traffic density.
Conclusion: Several multi-level factors influence physical activity among church members. While it is pertinent to address personalfactors, family and community factors also promote PA, therefore, group-level interventions may be warranted. Strategies that address the socio-cultural norms that serve as barriers to PA should also be included in the design of church-based PA programmes.
Keywords: Physical activity; faith-based organization; determinants.
Clinical roles of autophagy-related proteins Beclin-1 and mTOR in smoking and non-smoking patients with oral leukoplakia
Authors: Zhang Ping , Zhou Peng , Yao Min 
Published: October 2023

Background: To study the expressions of autophagy-related proteins Beclin-1 and mammalian target of rapamycin (mTOR) insmoking and non-smoking patients with oral leukoplakia (OLK).
Methods: A total of 240 patients diagnosed as OLK from January 2017 to December 2017 were enrolled. Beclin-1 and mTORexpressions were detected by immunohistochemistry. Their clinical data were collected. The correlations of smoking with Beclin-1 and mTOR expressions as well as clinical factors were explored by Spearman’s analysis.
Results: There were significant differences in gender ratio, age, lesion location, severity and malignancy between smoking andnon-smoking OLK patients (P<0.05). The positive expression rate of Beclin-1 in OLK patients with simple hyperplasia andabnormal hyperplasia in the smoking group was significantly lower than that of the non-smoking group (P<0.05). In the abnormalhyperplasia group, the number of cigarettes daily was significantly positively correlated with mTOR expression (r=0.843, P=0.042). After the simple hyperplasia group was included, there was a positive correlation between smoking age and positive expression rate of mTOR (r=0.942, P=0.012). For number of cigarettes and smoking age, the positive expression rates of Beclin-1 and mTOR showed significant negative correlations (r=-0.952, P=0.003, r=-0.953, P=0.002).
Conclusion: Autophagy-related proteins Beclin-1 and mTOR may be involved in the smoking-induced pathogenesis of OLK.
Keywords: Smoking; oral leukoplakia; autophagy; Beclin-1; mammalian target of rapamycin.
Factors influencing clinical pregnancy outcome of in vitro fertilization/ intracytoplasmic sperm injection in older women
Authors: Gao Jinyu , Liu Zhaohua , Zhong Yao , Li Nannan , Tang Tingting 
Published: October 2023

Objective: To analyse the factors influencing clinical pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in older women, and to establish a risk prediction model.
Methods: A total of 425 patients receiving IVF/ICSI from March 2018 to March 2020 were divided into pregnancy group (n=194) and non-pregnancy group (n=231). The factors affecting the outcomes of IVF/ICSI were explored by univariate and multivariate logistic regression analyses. A nomogram prediction model was constructed.
Results: The two groups had significantly different age, body mass index, dysmenorrhea, parity, times of full-term births, history of cesarean section, basal follicle stimulating hormone, basal antral follicle count (AFC), number of high-quality embryos, and basal estradiol, luteinizing hormone and endometrial thickness on the day of human chorionic gonadotropin (HCG) administration (P<0.05). Age ≥40 years old, dysmenorrhea, history of cesarean section, basal AFC<9, number of high-quality embryos <4, and endometrial thickness on the day of HCG administration <11 mm led to IVF/ICSI failure. The established model exhibited high calibration and discrimination degrees in predicting the outcome of IVF/ICSI.
Conclusion: The risk prediction model for the pregnancy outcome of IVF/ICSI in older women helps evaluate the fertility probability and risk, providing references for formulating reasonable assisted reproduction plans.
Keywords: Older pregnant woman; in vitro fertilization/intracytoplasmic sperm injection; pregnancy outcome; risk factor; nomogram prediction model.
Prevalence, influencing factors, and outcomes of emergency caesarean section in public hospitals situated in the urban state of Lagos, Nigeria
Authors: Banke-Thomas Aduragbemi , Ke-on Avoka Cephas , Ogunyemi Olakunmi 
Published: October 2023

Background: Caesarean section (CS) performed in an emergency can be life-saving for both the pregnant woman and her baby. In Nigeria, CS rates have been estimated to be 2.7% nationally, with the highest regional rate of 7.0% reported in the South-West of the country. Our objective in this facility-based retrospective cross-sectional study was to describe patterns and assess factors, obstetric indications, and outcomes of emergency CS in Lagos, Nigeria.
Methods: Socio-demographic, travel, and obstetric data of pregnant women were extracted from case notes. Travel data was inputted in Google Maps to extract travel time from the pregnant women’ home to the hospital. Univariate, bivariate and multivariable logistic regression analyses were conducted.
Results: Of the 3,134 included pregnant women, 1,923 (61%) delivered via emergency CS. The odds of an emergency CS were significantly higher among women who were booked (OR=1.97, 95%CI 1.64–2.35), presented with obstructed labour (OR=2.59, 95%CI 1.68–3.99), pre-eclampsia/eclampsia (OR=1.67, 95%CI 1.08–2.56), multiple gestations (OR=2.71, 95%CI 1.72–4.28) and travelled from suburban areas (OR=1.43, 95%CI 1.15–1.78). There was an increasing dose-effect response between travel time to the hospital and emergency CS.
Conclusion: Optimisation of CS rates requires a multi-pronged approach during pregnancy and childbirth, with particular emphasis on supporting pregnant women living in the suburbs.
Keywords: Caesarean section; emergency obstetric care; prevalence; factors; urban; Nigeria.