bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visible‐Light‐Driven Rapid 3D Printing of Photoresponsive Resins for Optically Clear Multifunctional 3D Objects
Authors: Shin Sangbin , Kwon Yonghwan , Hwang Chiwon , Jeon Woojin , Yu Youngchang , Paik Hyun‐Jong , Lee Wonjoo , Kwon Min Sang , Ahn Dowon 
Published: January 2024

AbstractLight‐driven 3D printing is gaining significant attention for its unparalleled build speed and high‐resolution in additive manufacturing. However, extending vat photopolymerization to multifunctional, photoresponsive materials poses challenges, such as light attenuation and interference between the photocatalysts (PCs) and photoactive moieties. This study introduces novel visible‐light‐driven acrylic resins that enable rapid, high‐resolution photoactive 3D printing. The synergistic combination of a cyanine‐based PC, borate, and iodonium coinitiators (HNu 254) achieves an excellent printing rate and feature resolution under low‐intensity, red light exposure. The incorporation of novel hexaarylbiimidazole (HABI) crosslinkers allows for spatially‐resolved photoactivation upon exposure to violet/blue light. Furthermore, a photobleaching mechanism inhibited by HNu 254 during the photopolymerization process results in the production of optically‐clear 3D printed objects. Real‐time Fourier transform infrared spectroscopy validates the rapid photopolymerization of the HABI‐containing acrylic resin, whereas mechanistic evaluations reveal the underlying dynamics that are responsible for the rapid photopolymerization rate, wavelength‐orthogonal photoactivation, and observed photobleaching phenomenon. Ultimately, this visible‐light‐based printing method demonstrates: (i) rapid printing rate of 22.5 mm h−1, (ii) excellent feature resolution (≈20 µm), and (iii) production of optically clear object with self‐healing capability and spatially controlled cleavage. This study serves as a roadmap for developing next‐generation “smart” 3D printing technologies.
4D Multimaterial Printing of Soft Actuators with Spatial and Temporal Control
Authors: Zhou Kun , Sun Rujie , Wojciechowski Jonathan P. , Wang Richard , Yeow Jonathan , Zuo Yuyang , Song Xin , Wang Chunliang , Shao Yue , Stevens Molly M. 
Published: January 2024

AbstractSoft actuators (SAs) are devices which can interact with delicate objects in a manner not achievable with traditional robotics. While it is possible to design a SA whose actuation is triggered via an external stimulus, the use of a single stimulus creates challenges in the spatial and temporal control of the actuation. Herein, a 4D printed multimaterial soft actuator design (MMSA) whose actuation is only initiated by a combination of triggers (i.e., pH and temperature) is presented. Using 3D printing, a multilayered soft actuator with a hydrophilic pH‐sensitive layer, and a hydrophobic magnetic and temperature‐responsive shape‐memory polymer layer, is designed. The hydrogel responds to environmental pH conditions by swelling or shrinking, while the shape‐memory polymer can resist the shape deformation of the hydrogel until triggered by temperature or light. The combination of these stimuli‐responsive layers allows for a high level of spatiotemporal control of the actuation. The utility of the 4D MMSA is demonstrated via a series of cargo capture and release experiments, validating its ability to demonstrate active spatiotemporal control. The MMSA concept provides a promising research direction to develop multifunctional soft devices with potential applications in biomedical engineering and environmental engineering.
Exceptional Performance of Room Temperature Sputtered Flexible Thermoelectric Thin Film Using High Target Utilisation Sputtering Technique
Authors: Tao Xudong , Dutson James , Zeng Chongyang , Asker Ceyla , Luong Sally , Reza Abdallah , Hao Botao , Zhang Zheng , Ellingford Joshua , Bonilla Ruy Sebastian , Fenwick Oliver , Bilotti Emiliano , Hofmann Felix , Thwaites Mike , Assender Hazel E. 
Published: January 2024

AbstractThe High Target Utilisation Sputtering technique (HiTUS) is of interest for industrial processes, including in roll‐to‐roll manufacturing. This study marks the first application of HiTUS to thermoelectric materials, exemplified by bismuth telluride. The HiTUS technique separates the sputtering power into the plasma power and the target power, with additional kinetic energy in the sputtering particles from the applied electrical field, thus enabling a much wider sputter parameter space to modify the film performance. This study investigates how plasma power, target power, and substrate bias in HiTUS intricately influence crystal orientation/size, elemental composition, surface morphology, and other film properties. These factors subsequently affect carrier density/mobility, and consequently the thermoelectric performance of the bismuth telluride film. These deposited films reach a power factor of 6.5 × 10−4 W m−1 K−2 with a figure of merit ≈0.14 at room temperature, the highest value for room‐temperature sputtered un‐doped bismuth telluride. Subsequent post‐deposition annealing significantly enhances the crystallinity of the film (highly polycrystalline), further improving the power factor to 23.5 × 10−4 W m−1 K‐2, with a figure of merit ≈0.45 at room temperature. The excellent performance of the HiTUS fabricated thermoelectric film opens opportunities for the large‐area manufacture of thin‐film thermoelectric materials and devices.
Interfacial and emulsion properties of albumin‐rich fractions from sunflower seeds
Authors: Diekmann Sabrina , Drusch Stephan , Brückner‐Gühmann Monika 
Published: January 2024

AbstractThe interfacial and emulsion properties of mixed albumin‐rich fractions extracted from sunflower seeds at pH 3 and pH 5 were analyzed. SDS‐PAGE under reducing and non‐reducing conditions was used to visualize differences between the protein fractions. The interfacial activity of the albumin‐rich fractions was analyzed via drop contour measurement. The viscoelasticity of the protein film the interactions between the protein molecules, and the network forming within the protein film were measured by interfacial shear rheology. Besides being both surface active, albumin‐rich fractions extracted at pH 5 were found to form interfacial films that exhibited a greater stability against deformation. In consequence, emulsions prepared with pH 5 extracts showed better properties represented by a smaller oil droplet size and a lower creaming index. The results proof that mixed albumin‐rich fractions can stabilize emulsions. Moreover, the presence of co‐extracted phenolic compounds seems to be important to generate systems with increased elastic properties of the interfacial film.
Design, synthesis, and activity evaluation of novel multitargeted l‐tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease
Authors: Zeng Xianghao , Cheng Shaobing , Li Huilan , Yu Haiyang , Cui Yushun , Fang Yuanying , Yang Shilin , Feng Yulin 
Published: January 2024

AbstractAlzheimer's disease (AD) is a multifactorial neurological disease, and the multitarget directed ligand (MTDL) strategy may be an effective approach to delay its progression. Based on this strategy, 27 derivatives of l‐tryptophan, 3a‐1–3d‐1, were designed, synthesized, and evaluated for their biological activity. Among them, IC50 (inhibitor concentration resulting in 50% inhibitory activity) values of compounds 3a‐18 and 3b‐1 were 0.58 and 0.44 μM for human serum butyrylcholinesterase (hBuChE), respectively, and both of them exhibited more than 30‐fold selectivity for human serum acetylcholinesterase. Enzyme kinetics studies showed that these two compounds were mixed inhibitors of hBuChE. In addition, these two derivatives possessed extraordinary antioxidant activity in OH radical scavenging and oxygen radical absorption capacity fluorescein assays. Meanwhile, these compounds could also prevent β‐amyloid (Aβ) self‐aggregation and possessed low toxicity on PC12 and AML12 cells. Molecular modeling studies revealed that these two compounds could interact with the choline binding site, acetyl binding site, and peripheral anionic site to exert submicromolar BuChE inhibitory activity. In the vitro blood–brain barrier permeation assay, compounds 3a‐18 and 3b‐1 showed enough blood–brain barrier permeability. In drug‐likeness prediction, compounds 3a‐18 and 3b‐1 showed good gastrointestinal absorption and a low risk of human ether‐a‐go‐go‐related gene toxicity. Therefore, compounds 3a‐18 and 3b‐1 are potential multitarget anti‐AD lead compounds, which could work as powerful antioxidants with submicromolar selective inhibitory activity for hBuChE as well as prevent Aβ self‐aggregation.
Adaptive tracking control for a class of nonlinear systems with intermittent actuator faults under prescribe output tracking performance
Authors: Lu Li‐Ting , Han Yu‐Qun , Wang Dong‐Mei , Zhu Shan‐Liang , Zhou Qing‐Hua 
Published: January 2024

AbstractThis paper investigates the adaptive tracking control problem of a class of nonlinear systems with intermittent actuator faults and prescribed performance. In the backstepping design process, a performance function is incorporated to ensure that the tracking error adheres to the prescribed performance criteria. Simultaneously, multi‐dimensional Taylor networks are used to approximate the unknown nonlinear functions in the system. Subsequently, to avoid jumps in the improved Lyapunov function when faults occur, a boundary estimation method is presented, which effectively compensates for the impact of intermittent actuator faults. Ultimately, based on Lyapunov stability theory, it is proven that all signals of the closed‐loop system are bounded, and the tracking error can satisfy the prescribed transient and steady‐state performance. Simulation results demonstrate the effectiveness of the proposed scheme.
Improving the substrate binding of acetyl‐CoA carboxylase (AccB) from Streptomyces antibioticus through computational enzyme engineering
Authors: Ali Imtiaz , Wei Dong‐Qing , Khan Abbas , Feng Yuanyuan , Waseem Muhammad , Hussain Zahid , Iqbal Arshad , Ali Syed Shujait , Mohammad Anwar , Zheng Jianting 
Published: January 2024

AbstractMalonyl‐CoA serves as the main building block for the biosynthesis of many important polyketides, as well as fatty acid–derived compounds, such as biofuel. Escherichia coli, Corynebacterium gultamicum, and Saccharomyces cerevisiae have recently been engineered for the biosynthesis of such compounds. However, the developed processes and strains often have insufficient productivity. In the current study, we used enzyme‐engineering approach to improve the binding of acetyl‐CoA with ACC. We generated different mutations, and the impact was calculated, which reported that three mutations, that is, S343A, T347W, and S350W, significantly improve the substrate binding. Molecular docking investigation revealed an altered binding network compared to the wild type. In mutants, additional interactions stabilize the binding of the inner tail of acetyl‐CoA. Using molecular simulation, the stability, compactness, hydrogen bonding, and protein motions were estimated, revealing different dynamic properties owned by the mutants only but not by the wild type. The findings were further validated by using the binding‐free energy (BFE) method, which revealed these mutations as favorable substitutions. The total BFE was reported to be −52.66 ± 0.11 kcal/mol for the wild type, −55.87 ± 0.16 kcal/mol for the S343A mutant, −60.52 ± 0.25 kcal/mol for T347W mutant, and −59.64 ± 0.25 kcal/mol for the S350W mutant. This shows that the binding of the substrate is increased due to the induced mutations and strongly corroborates with the docking results. In sum, this study provides information regarding the essential hotspot residues for the substrate binding and can be used for application in industrial processes.
Unveiling the Potential of Silicon‐Air Batteries for Low‐Power Transient Electronics: Electrochemical Insights and Practical Application
Authors: Montiel Guerrero Saul Said , Durmus Yasin Emre , Tempel Hermann , Roth Christian , Kungl Hans , van Waasen Stefan , Ein‐Eli Yair , Eichel Rüdiger‐A. 
Published: January 2024

AbstractWith growing demand for energy storage alternatives, silicon‐air batteries have gained attention due to their impressive theoretical specific energy (8470 Wh kgSi−1) and theoretical specific capacity (3820 mAh gSi−1). Although current challenges, such as corrosion, low anode mass conversion efficiency, and limited power output, restrict their practical use and commercialization potential, the ongoing advancement of materials and efficient electronic components open up a range of potential applications for Silicon‐air (Si‐air) batteries. This study investigates the feasibility of employing a single alkaline or non‐aqueous silicon‐air battery to power low‐power transient electronic device. Initially, their electrochemical behavior, corrosion parameters, and performance were assessed, yielding crucial parameters for the circuit design. Short‐term galvanostatic discharge experiments demonstrated the effective operation of Si‐air battery under varying current densities in both electrolytes without passivation issues. Subsequently, a proof‐of‐concept for self‐consumed and self‐destructive transient electronic device is presented, wherein a full‐cell Si‐air battery with non‐aqueous and aqueous electrolytes was operated while powering a light‐emitting diode (LED) as a practical illustrative application.
Development of bioreactor scale‐down model using orthogonal projections to latent structures method and CO2 supplementation
Authors: Gao Jinxin , Hazeltine Laurie B. , Stroud Neal , Liu Ning , Huang Yao‐ming 
Published: January 2024

AbstractScale‐down model qualification is an important step for developing a large‐scale cell culture process to enhance process understanding and support process characterization studies. Traditionally, only harvest data are used to show consistency between small‐scale and large‐scale bioreactor performance, allowing attributes that are dynamic over the cell culture period to be overlooked. A novel statistical method, orthogonal projections to latent structures (OPLS) analysis, can be utilized to compare time‐course cell culture data across scales. Here we describe an example where OPLS is used to identify gaps between small‐scale and large‐scale bioreactor performances. In this case, differences in the partial pressure of carbon dioxide (pCO2) and lactate profiles were observed between small‐ and large‐scale bioreactors, which were linked to differences in the product‐quality attributes fragments and galactosylation. An improved small‐scale model was developed, leading to improved consistency in the process performance and product qualities across scales and qualification of the scale‐down model for regulatory submissions. This new statistical approach can provide valuable insights into process understanding and process scale‐up.
Enhancing cell separation in a hybrid spiral dielectrophoretic microchannel: Numerical insights and optimal operating conditions
Authors: Uddin Mohammed Raihan , Chen Xiaolin 
Published: January 2024

AbstractReliable separation of circulating tumor cells from blood cells is crucial for early cancer diagnosis and prognosis. Many conventional microfluidic platforms take advantage of the size difference between particles for their separation, which renders them impractical for sorting overlapping‐sized cells. To address this concern, a hybrid inertial‐dielectrophoretic microfluidic chip is proposed in this work for continuous and single‐stage separation of lung cancer cell line A549 cells from white blood cells of overlapping size. The working mechanism of the proposed spiral microchannel embedded with planar interdigitated electrodes is validated against the experimental results. A numerical investigation is carried out over a range of flow conditions and electric field intensity to determine the separation efficiency and migration characteristics of the cell mixture. The results demonstrate the unique capability of the proposed microchannel to achieve high‐throughput separation of cells at low applied voltages in both vertical and lateral directions. A significant lateral separation distance between the CTCs and the WBCs has been achieved, which allows for high‐resolution and effective separation of cells. The separation resolution can be controlled by adjusting the strength of the applied electric field. Furthermore, the results demonstrate that the lateral separation distance is maximum at a voltage termed the critical voltage, which increases with the increase in the flow rate. The proposed microchannel and the developed technique can provide valuable insight into the development of a tunable and robust medical device for effective and high‐throughput separation of cancer cells from the WBCs.
Disabling tinnitus and third nerve palsy following pontine hemorrhage: Application of ICF framework
Authors: Krishnan Muthaiah Vijaya Prakash , Cornejo Ignacio Novoa , Hariharan Sabarish , Thyagarajan Murugaraj , Gunasekaran Krishnamoorthy 
Published: January 2024

Key Clinical MessageSpontaneous intracerebral hemorrhage commonly affects the brainstem. This report describes a 31‐year‐old male with hypertension who developed a pontine hemorrhage. The neurological deficits included left‐third nerve palsy, right‐sided weakness, and disabling tinnitus. Tinnitus is linked to central auditory pathway disruption. Magnetic resonance imaging revealed the hemorrhagic lesion and additional micro‐hemorrhages. The International Classification of Functioning, Disability, and Health (ICF) enhances rehabilitation by characterizing multifaceted stroke disability. The ICF profile revealed impairments in body structures/functions, limitations in activities/participation, and positive/negative environmental factors. ICF‐based goal‐setting informed interventions, including tinnitus retraining and physical/occupational therapy. Comprehensive ICF assessment is crucial for optimized, patient‐centered post‐stroke rehabilitation as it determines the extent of impact on functional level of the patient irrespective of disease severity.
Late‐onset aspirin‐related hemolysis and subsequent subdural hemorrhage in patient with glucose‐6‐phosphate dehydrogenase deficiency
Authors: Li Jianle , Chen Yicong , Deng Weisheng , Zeng Jinsheng 
Published: January 2024

Key Clinical MessageAspirin‐related hemolysis in G6PD deficiency could be late‐onset during long‐term administration. Hemolytic anemia could continue for a relatively long time in elder patient with G6PD deficiency, which might be related to other adverse events.AbstractAspirin‐related hemolysis in G6PD‐deficient individuals was generally reported among patients who received high‐dose supplements within several days after ingestion. The safety of long‐term and low‐dose (50–325 mg/day) aspirin in patients coexist G6PD deficiency and cardiovascular disease is neglected in clinical practice. In this case, we observed a late‐onset hemolysis and subsequent fatal subdural hemorrhage in one G6PD‐deficient individual who had received long‐term and low‐dose aspirin. An 83‐year‐old male was diagnosed with acute ischemic stroke and treated with 100 mg/day aspirin at the emergency room. After admission, the patient was diagnosed with severe G6PD deficiency based on enzyme activity, but no hemolysis occurred within 10‐day aspirin therapy in the hospital. Hence, 100 mg/day aspirin was continued on discharge. Two months later, the patient presented acute hemolysis manifested as fatigue, dark urine, and moderate jaundice. Although hemolysis was self‐limit in a few days, hemoglobin decline continued for 20 days until a fatal subdural hemorrhage occurred. Our study indicated aspirin‐related hemolysis could be late‐onset in G6PD‐deficient individual even receiving low‐dose treatment and is probably linked to subsequent major bleeding events.
Myeloid sarcoma presenting as fingertip necrosis with underlying suppurative tenosynovitis: A case report
Authors: Bloomfield Grace , Finkel Francisca , Mun’em Al Hourani Abdel , Gupta Shivani , Jain Esha , Magee Amanda 
Published: January 2024

Key Clinical MessageWe report an unusual case presentation of a patient with necrotic tissue changes of the right second and third fingers, found to have myeloid sarcoma with Staphylococcus‐positive tenosynovitis and underlying acute myeloid leukemia, to highlight the importance of comprehensive evaluation in patients with atypical wounds.
Identifying Active Sites of Pt‐NiFe LDH Catalysts for CO Oxidation Using In‐Situ DRIFTS with Multiple Microscopy and Spectroscopy Techniques
Authors: Liang Qing , Li Wenwen , Meng Fanling , Song Kexin , Feng Yu , Liu Yuhua , Liu Meiqi , Huang Chengxiang , Tao Youkun , Chen Zhongjun , Shao Jing , Zhang Wei 
Published: January 2024

AbstractLayered double hydroxide (LDH) nanostructures are commonly used to study the interfacial effects of Pt‐based catalysts in CO oxidation. However, the specific role and detailed intermediates involved in CO oxidation remain unclear. Density functional theory (DFT) predicted that NiFe LDH loaded with single Pt atoms would exhibit satisfactory CO oxidation activity. On this basis, we prepared Pt1NiFe LDH catalysts with various Fe : Ni ratios by using the one‐pot method and achieved favorable dispersion of single Pt atoms. Pt1/FN‐1, which had the optimal Fe : Ni ratio (1 : 1), exhibited satisfactory catalytic performance for CO oxidation and a high turnover frequency, as determined through DFT calculations and experimental characterization. In‐situ diffuse reflectance infrared Fourier transform spectroscopy confirmed that CO directly reacted with Pt1/FN‐1 to produce CO2 and that introduced O2 formed bicarbonate species to produce CO2 together with the adsorbed CO on Pt1 sites. Overall, our work provides new insights into the catalytic mechanism of the well‐known Pt1NiFe LDH catalysts in CO oxidation.
Focused Ultrasound‐Responsive Nanocomposite with Near‐Infrared II Mechanoluminescence for Spatiotemporally Selective Immune Activation in Lymph Nodes
Authors: Xu Sixin , Li Xiaohe , Hu Qian , Zhang Jieying , Li Ruotong , Meng Lingkai , Zhu Xingjun 
Published: January 2024

AbstractThe immune regulation of the lymphatic system, especially the lymph node (LN), is of great significance for the treatment of diseases and the inhibition of pathogenic organisms spreading in the body. However, achieving precise spatiotemporal control of immune cell activation in LN in vivo remains a challenge due to tissue depth and off‐target effects. Furthermore, minimally invasive and real‐time feedback methods to monitor the regulation of the immune system in LN are lacking. Here, focused ultrasound responsive immunomodulator loaded nanoplatform (FURIN) with near‐infrared II (NIR‐II) luminescence is designed to achieve spatiotemporally controllable immune activation in LN in vivo. The NIR‐II persistent luminescence of FURIN can track its delivery in LN through bioimaging. Under focused ultrasound (FUS) stimulation, the immunomodulator encapsulated in FURIN can be released locally in the LN to activate immune cells such as dendritic cells and the NIR‐II mechanoluminescence of FURIN provides real‐time optical feedback signals for immune activation. This work points to a FUS mediated, spatiotemporal selective immune activation strategy in vivo with the feedback control of luminescence signals via ultrasound responsive nanocomposite, which is of great significance in improving the efficacy and reducing the side effect of immune regulation for the development of potential immunotherapeutic methods in the future.