bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the Persian Gaming Disorder Test and relationships with psychological distress and insomnia in adolescents
Authors: Lin Chung-Ying , Potenza Marc N. , Pontes Halley M. , Pakpour Amir H. 
Published: October 2023

Abstract
Background
Gaming Disorder (GD) was recently included by the World Health Organization (WHO) as a psychiatric condition in the eleventh revision of the International Classification of Diseases (ICD-11) and is a concern worldwide, including in Iran. Thus, based on the ICD-11 criteria, a Persian version of the Gaming Disorder Test (GDT) was developed to facilitate assessment of GD.

Methods
The present study used classical test theory and Rasch analysis to examine the psychometric properties of the Persian GDT. Iranian adolescents (n = 3837; 2171 [56.6%] males; mean [SD] age = 16.02 [1.4] years) completed the GDT and other instruments assessing disordered gaming, psychological distress, and insomnia.

Results
Overall, the psychometric properties of the Persian GDT were satisfactory based on classical test theory (i.e., confirmatory factor analysis corroborated the unidimensional structure of GDT) and Rasch analysis (i.e., fit statistics suggested that all items were embedded in the concept of GD). Moreover, the Persian GDT was found to be sex-invariant, displaying no items with substantial differential item functioning across sexes. Additionally, it was found that GD mediated associations between time spent gaming and measures of psychological distress and insomnia.

Conclusion
The Persian GDT is a convenient and short instrument for assessing GD among Iranian adolescents. The mediating roles of GD in the associations between time spent gaming and psychological distress and between time spent gaming and insomnia suggest that targeting features of GD may reduce psychological distress and improve sleep for Iranian adolescents.
Current innovative approaches in reducing polycyclic aromatic hydrocarbons (PAHs) in processed meat and meat products
Authors: Das Arun K. , Bhattacharya Dipanwita , Das Annada , Nath Santanu , Bandyopadhyay Samiran , Nanda Pramod Kumar , Gagaoua Mohammed 
Published: October 2023

AbstractThe presence of polycyclic aromatic hydrocarbons (PAHs) in processed meat and meat products is a global concern as they are known to be carcinogenic, mutagenic, teratogenic, and genotoxic to living beings. PAHs are generated in processed meat through different thermo-processing techniques, such as smoking, grilling, barbecuing, roasting, and frying, which involve abnormal high-temperature treatments and extruded fuels. These carbonaceous compounds with two or more cyclic benzene rings are highly stable and toxic, and their generation is enhanced by faulty thermal processing techniques, contaminated raw materials, and environmental pollution. Based on their degree of toxicity, Benzo[a]pyrene (B[a]P) is recognized as the most probable human carcinogen among different fractions of PAHs by the European Commission Regulation (EC-No.1881/2006). Furthermore, the association between dietary PAHs exposures and their role as carcinogen in human beings has been reported clinically. Therefore, it is necessary to focus on prevention and control of PAHs formation in processed meat products through various strategies to avert public health concerns and safety issues. Accordingly, several approaches have been used to reduce the risk of PAHs formation by employing safe processing systems, harmless cooking methods, marination by natural plant components, use of biological methods etc. to eliminate or reduce the harmful effects of PAHs in the food system. This review provides a comprehensive insight into the occurrence and formation of PAHs in meat and meat products and their toxicological effects on human beings. Furthermore, the different cost-effective and environment friendly methods that have been employed as “green strategies” to mitigate PAHs in meat and meat products at both household and commercial levels are discussed.
Graphical Abstract
LncRNA PVT1 induces apoptosis and inflammatory response of bronchial epithelial cells by regulating miR-30b-5p/BCL2L11 axis in COPD
Authors: Fu Taoli , Tian Hui , Rong Hui , Ai Ping , Li Xiaoping 
Published: October 2023

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as a biomarker for COPD progression. Nonetheless, its specific functions and mechanisms in COPD are unclarified.

Methods
Cigarette smoke extract (CSE) was utilized to stimulate 16HBE cells, and cigarette smoke combining with lipopolysaccharide (LPS) was employed to induce COPD in rats. Western blotting and RT-qPCR were utilized for measuring protein and RNA levels. Flow cytometry was implemented for detecting cell apoptosis. Concentrations of inflammatory factors TNF-α and IFN-γ were examined using ELISA. Luciferase reporter assay was utilized for verifying the interaction between molecules. Hematoxylin–eosin staining was performed for histological analysis of rat lung tissues.

Results
PVT1 was highly expressed in CSE-stimulated 16HBE cells and the lungs of COPD rats. PVT1 depletion restored the viability, restrained apoptosis and hindered inflammatory cytokine production in 16HBE cells under CSE treatment and alleviated pathological damages in COPD rats. PVT1 bound to miR-30b-5p and miR-30b-5p targeted BCL2 like 11 (BCL2L11). Overexpressing BCL2L11 offset the above effects mediated by PVT1 in CSE-triggered 16HBE cells.

Conclusion
PVT1 enhances apoptosis and inflammation of 16HBE cells under CSE stimulation by modulating miR-30b-5p/BCL2L11 axis.
Violent behaviour in adolescents: assessment and formulation using a structured risk assessment tool
Authors: Pendlebury Gabrielle , Anderson Jane , Hales Heidi , Harding Duncan , Lewis Alexandra 
Published: October 2023

SUMMARYTeenagers often present in crisis with risk issues, mainly risk to self but sometimes risk to others. Adolescent violence is commonplace and is not just the remit of adolescent forensic psychiatry. Clinicians may lack confidence assessing risk of violence and can neglect vital areas that are essential to reduce risk. Use of structured violence risk assessments enables the multi-agency professional network to formulate a young person's presentation and their violence in a holistic way and consequently develop targeted risk management plans addressing areas such as supervision, interventions and case management to reduce the risk of future violence. Of the several validated tools developed for young people, the Structured Assessment of Violence Risk – Youth (SAVRY™) is that most used by UK-based forensic adolescent clinicians. This article outlines the epidemiology, causes and purposes of violence among adolescents; discusses types of risk assessment tool; explores and deconstructs the SAVRY; and presents a fictitious risk formulation.
Pilot study of a ketogenic diet in bipolar disorder
Authors: Needham Nicole , Campbell Iain H. , Grossi Helen , Kamenska Ivana , Rigby Benjamin P. , Simpson Sharon A. , McIntosh Emma , Bahuguna Pankaj , Meadowcroft Ben , Creasy Frances , Mitchell-Grigorjeva Maja , Norrie John , Thompson Gerard , Gibbs Melissa C. , McLellan Ailsa , Fisher Cheryl , Moses Tessa , Burgess Karl , Brown Rachel , Thrippleton Michael J. , Campbell Harry , Smith Daniel J. 
Published: October 2023

Background
Recent evidence from case reports suggests that a ketogenic diet may be effective for bipolar disorder. However, no clinical trials have been conducted to date.

Aims
To assess the recruitment and feasibility of a ketogenic diet intervention in bipolar disorder.

Method
Euthymic individuals with bipolar disorder were recruited to a 6–8 week trial of a modified ketogenic diet, and a range of clinical, economic and functional outcome measures were assessed. Study registration number: ISRCTN61613198.

Results
Of 27 recruited participants, 26 commenced and 20 completed the modified ketogenic diet for 6–8 weeks. The outcomes data-set was 95% complete for daily ketone measures, 95% complete for daily glucose measures and 95% complete for daily ecological momentary assessment of symptoms during the intervention period. Mean daily blood ketone readings were 1.3 mmol/L (s.d. = 0.77, median = 1.1) during the intervention period, and 91% of all readings indicated ketosis, suggesting a high degree of adherence to the diet. Over 91% of daily blood glucose readings were within normal range, with 9% indicating mild hypoglycaemia. Eleven minor adverse events were recorded, including fatigue, constipation, drowsiness and hunger. One serious adverse event was reported (euglycemic ketoacidosis in a participant taking SGLT2-inhibitor medication).

Conclusions
The recruitment and retention of euthymic individuals with bipolar disorder to a 6–8 week ketogenic diet intervention was feasible, with high completion rates for outcome measures. The majority of participants reached and maintained ketosis, and adverse events were generally mild and modifiable. A future randomised controlled trial is now warranted.
Prevalence of suicidal ideation and suicide attempts in individuals with psychosis and bipolar disorder in South Asia: systematic review and meta-analysis
Authors: Khoso Ameer B. , Noureen Amna , Un Nisa Zaib , Hodkinson Alexander , Elahi Anam , Arshad Usman , Naz Anum , Bhatti Mujeeb Masud , Asif Muqaddas , Husain Muhammad Omair , Husain Muhammad Ishrat , Chaudhry Nasim , Husain Nusrat , Chaudhry Imran B. , Panagioti Maria 
Published: October 2023

Background
Suicidal ideation and attempts are growing public health concerns globally. Evidence from high-income countries suggests that individuals with psychosis and bipolar disorder are at increased risk of suicidal ideation and attempts, but there is a scarcity of evidence from South Asia.

Aims
To estimate the prevalence of suicidal ideation and attempts in individuals with psychosis and bipolar disorder in South Asia.

Method
In this systematic review and meta-analysis, four databases (PsycINFO, Web of Science, EMBASE and Medline) were searched until December 2022. Pooled prevalence was estimated with random-effects models. Heterogeneity was quantified with the I2-statistic.

Results
The pooled sample size across the 21 studies was 3745 participants, 1941 (51.8%) of which were male. The pooled prevalence of suicide attempts in South Asian people with either psychosis or bipolar disorder was 22% (95% CI 17–27; n = 15). The pooled prevalence of suicidal ideation with psychosis or bipolar disorder combined was 38% (95% CI 27–51; n = 10). Meta-regression, subgroup and sensitivity analysis showed that the pooled prevalence estimates for both suicide attempt and ideation remained unaffected by variations in critical appraisal ratings and study designs. Only one study reported data on suicide-related deaths.

Conclusions
One in four individuals diagnosed with psychosis or bipolar disorder have reported suicide attempts, whereas up to one in three have experienced suicidal ideation. These findings underscore the urgent need for clinicians to regularly assess and monitor suicidal ideation and attempts among individuals with these disorders in South Asia.
Is the public goods game a chaotic system?
Authors: Bazeia D. , Ferreira M. J. B. , de Oliveira B. F. 
Published: October 2023

Abstract
This work deals with the time evolution of the Hamming distance density for the public goods game. We consider distinct possibilities for this game, which are exactly described by a function called q-exponential, that represents a deformation of the usual exponential function parametrized by q, suggesting that the system belongs to the class of weakly chaotic systems when

. These possibilities are related to the amount of players allowed in each game.
Graves’ Disease Following COVID-19 Vaccination: A Population-based, Matched Case-control Study
Authors: Gorshtein Alexander , Turjeman Adi , Duskin-Bitan Hadar , Leibovici Leonard , Robenshtok Eyal 
Published: October 2023

AbstractObjectiveMultiple cases and case series reported Graves’ disease (GD) following coronavirus disease 2019 (COVID-19) vaccination. We aimed to determine whether COVID-19 vaccination was associated with the incidence of GD.MethodsWe analyzed data from Clalit Health Services, the largest healthcare organization in Israel, which insures 4.7 million patients. A population-based, matched, case-control study was performed. Cases were defined as adult patients diagnosed with GD between December 2020 and November 2022. Each case was matched with controls in a 1:2 ratio. Each control was assigned an index date, which was identical to that of their matched case, defined as the date of GD diagnosis. Time between vaccination date and the diagnosis of GD or index date was assessed.ResultsA total of 726 patients with GD were matched with 1452 controls. The study patients and controls have received similar proportions of the COVID-19 vaccine [at least 1 dose: 80% (581/726) vs 77.8% (1129/1452), P = .22, respectively]. In a univariate analysis, at least 1 dose of the COVID-19 vaccine was not associated with the incidence of GD [odds ratio 95% confidence interval: 1.15 (.92-1.43)]. The mean time between first COVID-19 vaccination and the diagnosis of GD for cases or index date for controls was not significantly different [275.69 days (SD 144.37) for cases compared to 275.45 days (SD 145.76) for controls].ConclusionOur study found no association between COVID-19 vaccination and the incidence of GD.
Palmitate-induced insulin resistance causes actin filament stiffness and GLUT4 mis-sorting without altered Akt signalling
Authors: Tokarz Victoria L. , Mylvaganam Sivakami , Klip Amira 
Published: October 2023

ABSTRACT
Skeletal muscle insulin resistance, a major contributor to type 2 diabetes, is linked to the consumption of saturated fats. This insulin resistance arises from failure of insulin-induced translocation of glucose transporter type 4 (GLUT4; also known as SLC2A4) to the plasma membrane to facilitate glucose uptake into muscle. The mechanisms of defective GLUT4 translocation are poorly understood, limiting development of insulin-sensitizing therapies targeting muscle glucose uptake. Although many studies have identified early insulin signalling defects and suggest that they are responsible for insulin resistance, their cause–effect has been debated. Here, we find that the saturated fat palmitate (PA) causes insulin resistance owing to failure of GLUT4 translocation in skeletal muscle myoblasts and myotubes without impairing signalling to Akt2 or AS160 (also known as TBC1D4). Instead, PA altered two basal-state events: (1) the intracellular localization of GLUT4 and its sorting towards a perinuclear storage compartment, and (2) actin filament stiffness, which prevents Rac1-dependent actin remodelling. These defects were triggered by distinct mechanisms, respectively protein palmitoylation and endoplasmic reticulum (ER) stress. Our findings highlight that saturated fats elicit muscle cell-autonomous dysregulation of the basal-state machinery required for GLUT4 translocation, which ‘primes’ cells for insulin resistance.
Prognostic Significance of Pathologic Lymph Node Invasion in Metastatic Renal Cell Carcinoma in the Immunotherapy Era
Authors: Scheipner Lukas , Barletta Francesco , Cano Garcia Cristina , Incesu Reha-Baris , Morra Simone , Baudo Andrea , Assad Anis , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Briganti Alberto , Chun Felix K. H. , Tilki Derya , Longo Nicola , Carmignani Luca , Pichler Martin , Ahyai Sascha , Karakiewicz Pierre I. 
Published: October 2023

Abstract
Background
This study aimed to test the prognostic significance of pathologically confirmed lymph node invasion in metastatic renal cell carcinoma (mRCC) patients in this immunotherapy era.

Methods
Surgically treated mRCC patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2018. Kaplan-Meier plots and multivariable Cox-regression models were fitted to test for differences in cancer-specific mortality (CSM) and overall mortality (OM) according to N stage (pN0 vs pN1 vs. pNx). Subgroup analyses addressing pN1 patients tested for CSM and OM differences according to postoperative systemic therapy status.

Results
Overall, 3149 surgically treated mRCC patients were identified. Of these patients, 443 (14%) were labeled as pN1, 812 (26%) as pN0, and 1894 (60%) as pNx. In Kaplan-Meier analyses, the median CSM-free survival was 15 months for pN1 versus 40 months for pN0 versus 35 months for pNx (P < 0.001). In multivariable Cox regression analyses, pN1 independently predicted higher CSM (hazard ratio [HR], 1.88; P < 0.01) and OM (HR, 1.95; P < 0.01) relative to pN0. In sensitivity analyses addressing pN1 patients, postoperative systemic therapy use independently predicted lower CSM (HR, 0.73; P < 0.01) and OM (HR, 0.71; P < 0.01).

Conclusion
Pathologically confirmed lymph node invasion independently predicted higher CSM and OM for surgically treated mRCC patients. For pN1 mRCC patients, use of postoperative systemic therapy was associated with lower CSM and OM. Consequently, N stage should be considered for individual patient counseling and clinical decision-making.

Graphical abstract
Consort diagram of the study population.
Bright Red Luminescence from Ag–In–Ga–S-Based Quantum Dots with the Introduction of Copper
Authors: Uematsu Taro , Krobkrong Navapat , Asai Kenichiro , Motomura Genichi , Fujisaki Yoshihide , Torimoto Tsukasa , Kuwabata Susumu 
Published: October 2023

Abstract
This study presents cadmium-free, red-emission quantum dots (QDs) synthesized by incorporating Cu into silver indium gallium sulfide/gallium sulfide (Ag–In–Ga–S/Ga–S) core/shell QDs. By using a previous technique, in which the original Ag–In–Ga–S/Ga–S core/shell QDs exhibiting band-edge photoluminescence (PL) were improved to achieve a narrower emission and facile synthesis, we injected a mixture of Cu and Ag sources into a heated solution containing In, Ga, and S sources. This resulted in the formation of Ag–Cu–In–Ga–S quinary QDs without any precipitation. After being coated with a Ga–S shell, these QDs exhibit a red PL with a spectral full-width at half maximum of 55–60 nm. Although the PL wavelength was responsive to changes in In/Ga ratios, it was unaffected by variations in Cu/Ag ratios due to the transition between conduction band electrons and holes localized at Cu cites. Notably, the electroluminescence device exhibited high-purity red light that satisfies the recommendation ITU-R BT.2020 standard.
How useful is the tuberculin skin test for the detection of active tuberculosis: Assessing diagnostic accuracy metrics and selection of best cut-off value through a large Tunisian multicenter case-control study
Authors: Nouira Mariem , Ben Rayana Hazem , Ennigrou Samir 
Published: October 2023

Background and aim: During the past decade, the frequency of extrapulmonary forms of tuberculosis (TB) has increased. These forms are often miss-diagnosed. This statement of the TB epidemiological profile modification, conduct us to reflect about the utility of the Tuberculin Skin Test (TST) in active TB detection. This study aimed to evaluate the diagnostic accuracy performance of the TST for active tuberculosis detection. Methods: This was a case-control, multicenter study conducted in 11 anti-TB centers in Tunisia (June-November2014). The cases were adults aged between 18 and 55 years with newly diagnosed and confirmed tuberculosis. Controls were free from tuberculosis. A data collection sheet was filled out and a TST was performed for each participant. Diagnostic accuracy measures of TST were estimated using Receiver Operating Curve (ROC) curve and Area Under Curve (AUC) to estimate sensitivity and specificity of a determined cut-off point. Results: Overall, 1050 patients were enrolled, composed of 336 cases and 714 controls. The mean age was 38.3±11.8 years for cases and 33.6±11 years for controls. The mean diameter of the TST induration was significantly higher among cases than controls (13.7mm vs.6.2mm; p=10-6). AUC was 0.789 [95% CI: 0.758-0.819; p=0.01], corresponding to a moderate discriminating performance for this test. The most discriminative cut-off value of the TST, which was associated with the best sensitivity (73.7%) and specificity (76.6%) couple was ≥ 11 mm with a Youden index of 0.503. Positive and Negative predictive values were 3.11% and 99.52%, respectively. Conclusions: TST could be a useful tool used for active tuberculosis detection, with a moderate global performance and accepted sensitivity and specificity at the cut-off point of 11 mm. However, it cannot be considered as a gold standard test due to its multiple disadvantages.
Scaling Blockchains: Can Committee-Based Consensus Help?
Authors: Benhaim Alon , Falk Brett H. , Tsoukalas Gerry 
Published: October 2023

In the high-stakes race for scalability, some blockchains have turned to committee-based consensus (CBC), whereby the chain’s recordkeeping rights are entrusted to a committee of block producers elected via approval voting. Smaller committees boost speed and scalability but can compromise security when voters have limited information. In this environment, voting strategies are naturally nonlinear, and equilibria can become intractable. Despite this, we show that elections converge to optimality asymptotically (in voter numbers), exponentially quickly, and under relatively weak informational requirements. Compared to popular stake-weighted lottery and single-vote protocols used in practice, we find that CBC, when paired with approval voting, can offer meaningful efficiency and robustness gains if enough voters are engaged. This paper was accepted by Will Cong, Special Section of Management Science: Blockchains and Crypto Economics. Funding: This work was funded by The Hogeg Blockchain Research Institute. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.03177 .