bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma
Authors: Balushi Khalid Al , Hadhrami Abdulrahman Al , Balushi Hamdan Al , Lawati Abdullah Al , Das Srijit 
Published: December 2023

Abstract:
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults
and commonly occurs in the Caucasian population. The malignancy involves the uvea of the eye,
which includes the iris, ciliary body, and choroid. The etiology of UM is still not well understood,
but age is a risk factor. Symptoms include blurred vision, redness of the eye, floaters, dark spots, a
change in the size of the pupil, and loss of vision. The location, shape, and size of the tumor are
important for therapeutic purposes. Treating metastasis is always a challenge in UM cases. In cases
of lung metastasis, the survival rate decreases. Treatment includes surgery, laser therapy, immunotherapy,
hormone therapy, and chemotherapy. Recently, in 2022, the United States Food and
Drug Administration (FDA) approved the drug tebentafusp. Tebentafusp was developed to target
the most common HLA complex in humans. The present review discusses the indications for the
use of a new drug tebentafusp, its mechanism of action, dose, pharmacokinetics, results of clinical
trials conducted, and adverse effects like cytokine release syndrome. Hence, tebentafusp is the
first T cell receptor (TCR) therapeutic drug that could be considered for the treatment of UM.
Energy Optimization for RC and RLC Interconnect Design in Low Power
VLSI
Authors: Bhardwaj Himani , Jain Shruti , Sohal Harsh 
Published: December 2023

Background:
The global RC interconnects have become the controlling parameter for a
circuit’s performance. But with the decrease in technology, an increase in resistance has become
prominent. This increase further directly affects the performance of the system by increasing the performance
parameters of the circuit like delay and power consumption. To resolve this issue and to be
compatible with Internet of Things (IoT) applications, the interconnect circuits are required to be
high speed with less heat generation.

Methods:
In this paper, a new RC and RLC interconnect circuit design was proposed for 45 nm technology
to enhance the performance parameters. Furthermore, the RC interconnect design was simulated
for lumped and distributed networks. The parasitic component values (resistance, inductance,
and capacitance) are evaluated using PTM technology.

Results:
The proposed interconnect circuit's resistance value decreased by a factor of 4, but the capacitance
remains the same. Furthermore, power consumption and delay values were attained. An
overall comparison was done between RC and RLC networks.

Conclusion:
63.13% power improvement and 24.87% delay improvement were observed in the RLC
network over RC distributed network.
IN SILICO ASSESSMENT OF AMELIORATIVE EFFECTS OF POLYUNSATURATED FATTY ACID (PUFAS) FROM NAVICULA SALINICOLA AS AN INHIBITOR OF BENIGN PROSTATE HYPERPLASIA
Authors: FEBRINA ELLIN , YULIANTINI ANNE , KURNIA DEWI , ASNAWI AIYI 
Published: December 2023

Objective: Benign prostatic hyperplasia (BPH) is a prevalent, non-cancerous condition affecting aging men worldwide. As an alternative approach to conventional treatment options, polyunsaturated fatty acids (PUFAs) have gained attention for their potential therapeutic effects on various health conditions. This study investigated the interaction of PUFAs obtained from Navicula salinicola with the macromolecule associated with BPH, represented by STAT3, that is involved in the androgen signaling pathway in BPH (PDB ID 6NJS), using molecular docking simulations.
Methods: The docking simulations revealed the interaction patterns and binding affinities of 14 PUFAs with the amino acid residues of STAT3. The calculated binding energies and inhibition constants provided insights into the potential inhibitory effects of PUFAs on BPH.
Results: Results indicated that g-linolenic acid exhibited a strong binding affinity, forming hydrogen bonds with ARG609 and hydrophobic interactions with VAL637 and PRO639, highlighting its potential as a potent inhibitor. Docosahexaenoic acid also showed favorable interactions with ARG609 and hydrophobic residues, suggesting its potential therapeutic relevance.
Conclusion: g-Linolenic acid from N. salinicola exhibited a strong molecular interaction with STAT3.
EXPLORING BINDING AFFINITIES OF ACETOACETATE IN ACRYLAMIDE-BASED POLYMERS (PAM) FOR MOLECULARLY IMPRINTED POLYMERS (MIPS): A MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDY
Authors: ASNAWI AIYI , FEBRINA ELLIN , AMAN LA ODE , RAZI FACHRUL 
Published: December 2023

Objective: Molecularly Imprinted Polymers (MIPs) have garnered significant attention as promising materials for the selective recognition of target molecules. Acetoacetate is crucial in diabetes management, especially in Type 1 diabetes and diabetic ketoacidosis (DKA), and monitoring its levels is essential for detecting potential complications. In DKA, there is a lack of insulin resistance, leading to increased production of ketone bodies, including acetoacetate. MIPs, synthetic polymers, selectively bind to target molecules like acetoacetate due to unique three-dimensional structures, which can be quantitatively measured using molecular docking and molecular dynamics simulations. The research objectives were to assess the stability of acetoacetate-MIP complexes and their impact on polyacrylamide-based polymer (PAM) using molecular docking and molecular dynamics, examining their structural and energetic stability over 100 ns.
Methods: Five acrylamide-based polymers were investigated using AutoDock Vina for molecular docking and Gromacs for molecular dynamics simulations, focusing on binding affinities, hydrogen bonds, hydrophobic interactions, and complex behaviors over 100 ns.
Results: Acetoacetate binds well to the polymers PAM2 and PAM5, with the maximum binding affinity being 2.738 and 2.49 kcal/mol, respectively. PAM1, PAM3, and PAM4 had significant binding affinities; however, PAM4 had a lesser binding affinity of-1.534 kcal/mol, making it less appropriate for acetoacetate-specific MIP applications. The molecular dynamics investigation discovered that PAM5 had the best total energy, indicating a relatively stable interaction environment.
Conclusion: The study reveals PAM5 as a promising candidate with high binding affinity and multiple hydrogen bonds with acetoacetate, providing insights for acetoacetate-specific MIP design and molecular recognition progress.
Interfaces de um ensino pautado na escuta sensível
Authors: Lidoino Andreia Cristina Pontarolo , Silva Jacqueline Silva da 
Published: December 2023

Este artigo constitui um recorte da dissertação de mestrado que abordou a escuta sensível nas práticas de ensino de uma professora ao ensinar. Nele expõe-se de que forma a professora pesquisada efetiva essa prática e suas contribuições para a aprendizagem dos estudantes. A problemática levantada é a seguinte: Como a escuta sensível se apresenta no processo de ensino e aprendizagem de uma professora em atuação? O objetivo elencado é investigar a escuta sensível como ação mediadora nas práticas de ensino. Dessa forma, explicita-se como se deu o processo metodológico de coletas de dados. Escolheu-se a abordagem qualitativa para realizar a pesquisa, com aproximação do estudo de caso. Conforme evidenciado na pesquisa, a escuta sensível efetivada pela professora contribuiu para que os estudantes durante o ano letivo conseguissem manter um bom relacionamento e aprender de forma que incentivasse o protagonismo dos mesmos. Com base na escuta sensível, a professora realiza seu planejamento de forma a atender às especificidades pedagógicas de cada estudante, respeitando-os nas suas particularidades e formas diferentes de aprender.
Movimento indígena no equador: do movimento étnico para o movimento étnico-popular
Authors: Sousa Adilson Amorim de 
Published: December 2023

O movimento indígena equatoriano tem se constituído como um dos atores sociais mais importantes daquele país. Entre as organizações responsáveis pelo seu revigoramento merece destaque a Confederação das Nacionalidades Indígenas do Equador – CONAIE. Este artigo tem como objetivo central compreender o processo de transformação da identidade e do discurso de legitimação política da CONAIE buscando, por intermédio do estudo de suas práticas políticas desenvolvidas entre 1990 e 2000, discuti-la como principal força popular do Equador nesse período e uma das principais forças políticas antissistêmicas da América Latina na atualidade.
Peningkatan Kemandirian Santri Melalui Penguatan Young Entrepreneurship dan Edukasi Perilaku Hidup Bersih dan Sehat Serta Pelatihan dan Simulasi Alat P3K di Panti Asuhan Cabang Aisyiyah Matur Kabupaten Agam
Authors: Putra Hari Setia , Anis Ali , Zamil Ilham , Putri Indah Eka , Novariza Rika , Anggraini Diana Fitri , Sari Yollit Permata , Azmi Rafli Gumanda , Renggani Rinda 
Published: December 2023

Panti asuhan Asuhan Cabang Aisyiyah Matur Kabupaten Agam Sumatera Barat memiliki prinsip untuk membantu remaja yang berjuang untuk memenuhi kebutuhan jasmani, rohani, dan sosial mereka adalah salah satu lembaga tidak resmi yang menyediakan layanan sosial untuk anak-anak. Secara umum permasalahan yang ditemukan yaitu para santri: 1) belum memiliki usaha yang bisa dijalankan yang diharapkan dapat membantu perekonomiannya; 2) belum mendapatkan edukasi perilaku hidup bersih dan sehat dan 3) tidak bisa menggunakan alat kesehatan P3K. Solusi yang diberikan yaitu memberikan pelatihan kewirausahaan remaja, edukasi perilaku hidup bersih dan sehat serta penggunaan alat kesehatan P3K. Sebanyak 38 orang santri mengikuti kegiatan ini. Hasil yang dicapai adalah para santri memiliki pengetahuan dalam menciptakan peluang usaha yang bisa dijalan untuk membantu perekonomiannya sehingga terbentuk motivasi mengoptimalkan peluang wirausaha, memiliki pengetahuan PHBS serta terbiasa dalam menggunakan alat P3K. Diharapkan para siswa dapat mengembangkan bakat mereka, menjadi lebih kreatif dan produktif, dan memiliki potensi untuk memulai bisnis mereka sendiri.
Tengsl þjónustugæða, orðspors og ímyndar við frammistöðu skipulagsheilda
Authors: Guðlaugsson Þórhallur Örn 
Published: December 2023

Rannsóknir sýna að margt getur stuðlað að betri frammistöðu skipulagsheilda. Markmið þessarar rannsóknar er að kanna, út frá gæðum, orðspori og ímynd, breytileika í frammistöðu fyrirtækja. Byggt er á tveimur viðhorfskönnunum meðal notenda viðskiptabanka á Íslandi, önnur gerð vorið 2021 (n = 479) og hin vorið 2023 (n = 635) en heildarfjöldi gildra svara var 1.114. Það líkan sem þróað er í rannsókninni hefur fengið vinnuheitið QRI-P en spurningalistinn er þróaður út frá rannsókn á ímynd fjármálafyrirtækja sem hófst árið 2004. Í spurningalistanum er lagt mat á ímynd stærstu bankanna á Íslandi, gæði þjónustunnar sem og almennt viðhorf til þeirra. Um er að ræða þægindaúrtak og voru því svör vigtuð út frá aldri og kyni svo niðurstöður endurspegli betur afstöðu þýðisins, sem skilgreint er sem fólk á aldrinum 18-70 ára.
Lýsandi þáttagreining sýndi fram á sex þætti með eigingildi hærra en 1 en í framhaldinu var unnið með fimm þætti; almenn þjónustugæði, stafræn gæði, orðspor, ímynd og frammistöðu, en allir þessir þættir sýndu viðunandi innra réttmæti (α > 0,7) og útskýrðu 71% af breytileikanum í gögnunum. Niðurstöður aðhvarfsgreiningar sýndu að þættirnir útskýrðu 62% af breytileikanum í frammistöðu (R2 = 0,62). Af þeim þáttum sem notaðir voru kom í ljós að almenn gæði hafði mest vægi (β = 0,40) en sá þáttur einn og sér útskýrði 7,3% af breytileikanum í frammistöðu (P2 = 0,073). Sá þáttur sem hafði næst mest vægi var þátturinn orðspor (β = 0,28) sem útskýrði einn og sér 3,4% af breytileikanum í frammistöðu (P2 = 0,034) og þriðji mikilvægasti þátturinn var þátturinn ímynd (β = 0,16) sem útskýrði 1,4% af breytileikanum (P2 = 0,014). Sá þáttur sem útskýrði minnst af breytileikanum var þátturinn stafræn gæði (β = 0,09) en sá þáttur einn og sér útskýrði aðeins 0,5% af breytileikanum í frammistöðu (P2 = 0,005).
Pendampingan Kepada Pencari Keadilan di Pengadilan Agama Kudus melaui Mediasi dari Mediator Nonhakim
Authors: Suparnyo Suparnyo , Sukresno Sukresno 
Published: December 2023

The community service activities carried out at the Kudus Religious Court aim to make the members of the Kudus community whose marriages cause problems that lead to divorce proceedings. Before the divorce decision is handed down by the Religious Court Judge, mediation must be carried out by the mediator at the Kudus Religious Court so that it can be agreed that no divorce will occur. The mediator who will mediate the parties who will file for divorce can come from a Judge Mediator or a Non-Judge Mediator. This service accompanies the disputing parties when mediation is carried out by a non-judge mediator. This is done because there are still many disputing parties who cannot be mediated successfully so that divorce is still ongoing. The failure of Non-Judge Mediators in the Religious Courts in reconciling the disputing parties (husband and wife) is mostly due to the egos of each one which is difficult to understand the importance of marriage, so that many still end in divorce. Because of these conditions, there is still a need for socialization about marriage in general.
Valor da pessoa humana e a Declaração Universal dos Direitos Humanos à luz da Filosofia Kantiana
Authors: Rodrigues Giovana Flávia , Jeziorowski Ana Carolina de Faria Silvestre 
Published: December 2023

O presente artigo analisa, pelo método explicativo, como se deu o conceito de pessoa ao longo do tempo e em que se fundamenta sua dignidade. Para isso, baseia-se na filosofia de Immanuel Kant, acerca dos estudos da moral e da ética. Revisa também os fatos históricos que culminaram na criação da Organização das Nações Unidas e, posteriormente, na Declaração Universal dos Direitos Humanos, relacionando-a à proteção da dignidade humana. Destaca, ainda, os problemas éticos surgidos com o avanço e aperfeiçoamento da técnica e os obstáculos para a efetivação das normas de direitos fundamentais nas diversas culturas e circunstâncias. Por fim, conclui-se que o principal óbice para a realização dos ideais proclamados pela Carta das Nações Unidas é o modelo capitalista atual que acaba por aviltar a vida humana e personificar os interesses capitalistas. Propõe, ainda, como desafio, remodelar o sistema interno da Organização das Nações Unidas para se alcançar os seus objetivos.
Influence of the Microcrystalline Cellulose Dispersion Method on the Structure and Properties of Rigid Polyurethane Foam Composites
Authors: Węgrzyk Grzegorz , Grzęda Dominik , Leszczyńska Milena , Gloc Michał , Ryszkowska Joanna 
Published: December 2023

Abstract
This paper investigates the reinforcement of rigid polyurethane foams with microcrystalline cellulose to improve their mechanical and thermal properties. In this work, microcrystalline cellulose was added to polyol and was dispersed using two methods: calendering and ultrasounds. As a result of the study, it was found that the addition of micro cellulose to the polyol mixture used for the synthesis of polyurethane foam changes the properties of the final product. A crucial aspect is how it is added to the mixture. When adding microcrystalline cellulose particles, better results were obtained for particles dispersed using ultrasound. The most beneficial changes were obtained for the sample with 2php cellulose. The most significant reduction in average pore size was shown, which has a beneficial effect on the insulating properties of polyurethane foam. In addition, an increase in mechanical properties was also noted. Both properties are highly desirable in many applications.
Leading-Edge Polymer/Carbonaceous Nano-Reinforcement Nanocomposites—Opportunities for Space Sector
Authors: Kausar Ayesha , Ahmad Ishaq 
Published: December 2023

Abstract
Carbonaceous or nanocarbon nano-reinforcement nanocomposites have been found as emergent candidates for aerospace industry. Consequently, the multifunctional nanocomposites have been fabricated using marvelous nanocarbon nanostructures like graphene, carbon nanotube, fullerene, carbon black, etc. Manufacturing techniques have also been engrossed for the formation of high performance engineering nanocomposites having fine strength, heat stability, flame resistance, and other space desired features. These practices include solution, in situ, and melt procedures, on top of specific space structural design techniques, for the formation of aerospace structures. The aerospace related material property enhancements using various carbonaceous nano-reinforcements depends upon the type of nanocarbon, dimensionality, as well as inherent features of these nanostructures (in addition to the choice of manufacturing methods). Furthermore, carbon nano-reinforcements have been filled, besides carbon fibers, in the epoxy matrices. Nanocarbon coated carbon fibers have been filled in epoxy resins to form the high performance nanomaterials for space structures. The engineering features of these materials have been experiential appropriate for the aerospace structures. Further research on these nanomaterials may be a key towards future opportunities in the aero systems. Additionally, the explorations on structure-property relationships of the carbonaceous nanocomposites have been found indispensable for the development of advanced aerospace structures.
Prevalence of malocclusion and orthodontic treatment need in 10-year-old New Zealand children
Authors: Johnson Mark , Harkness Michael 
Published: December 2023

Abstract
The need for orthodontic treatment was determined in a random sample of 10-year-old Dunedin, New Zealand schoolchildren using the Dental Aesthetic Index (DAI); an index based on the social acceptability of dental appearance. When absent or unerupted teeth were disregarded, orthodontic treatment was considered to be “mandatory” for one-third of the children. The remaining children were almost equally divided into the three other treatment-need groups: “highly desirable”, “elective”, and “not necessary”. The majority of the children had crowding and spacing in at least one incisor segment, and a molar occlusion other than Angle Class I. In this predominately mixed-dentition sample, more children were considered to need orthodontic treatment than older children in studies using the DAI. This raises some questions about the suitability of the DAI as a tool to assess orthodontic treatment need in mixed-dentition samples.
Finishing occlusion, degree of stahility and the PAR index
Authors: Woods Michael , Lee Doug , Crawford Edward 
Published: December 2023

Abstract
The occlusions of sixty -five patients, treated by one private specialist orthodontist with consistent philosophy and goals, were assessed according to the PAR Index. For each patient, pre-treatment, post-treatment and follow-up study models were assessed. Follow-up models were taken at least 6.5 years following the removal of all retention appliances. Mean-weighted PAR scores were calculated for the total sample and various sub-groups at each stage. Mean percentage changes in weighted PAR scores were also calculated. The relationships between the occlusal standards at the end of active treatment and at the end of the follow-up period, and specific diagnostic and treatment factors were then investigated to search for any factors that might be predictive of long-term post-treatment occlusal stability or instability.
The overall mean-weighted pre-treatment, post-treatment and follow-up PAR scores were 25.5, 3.0 and 7.0, respectively. There was an 85.6 per cent decrease with treatment in the overall mean-weighted PAR score. This was followed by a 15.2 per cent increase in that overall mean during the follow-up period. In this introductory study, neither the PAR score at the end of active treatment, nor the amounts of occlusal change occurring during or after active treatment, were found to be predictive of the amount of post-treatment occlusal change.
An investigation of mandibular morphology in subjects with different vertical facial growth patterns
Authors: Barçin Eröz Ü. , Çeylan Ismail , Aydemir Sahsene 
Published: December 2023

Abstract
In the present study, mandibular morphology was investigated on lateral cephalometric head films and dental casts of 60 subjects (30 females and 30 males) who had different vertical facial growth patterns. The sample had a mean age of l3 .5 years, with a range of ll to 15.5 years. The subjects were divided into three groups with regard to vertical facial growth by using the SN/GoGn angle to define low-angle, normal, and high-angle groups. In addition, each group was divided into two subgroups according to sex. The effects of the SN/GoGn angle and gender on mandibular morphology were investigated by means of analysis of variances. Tan Go, IMPA, SL, and EL measurements were found to be related to SN/GoGn, and the measurements of Go-Gn, Symphysis depth, and Intermolar width to be related to sex.
Electropalatographic and cephalometric assessment of myofunctional therapy in open-bite subjects
Authors: Cayley A.S. , Tindall A.P. , Sampson W.J. , Butcher A.R. 
Published: December 2023

Abstract
Myofunctional therapy (MFT) is often prescribed to correct tongue-thrust swallowing, with the expectation that anterior open bite (AOB) will reduce spontaneously if a more posterior tongue posture is learned. However, MFT has not been subjected to systematic evaluation. Electropalatography (EPG), which is used in speech pathology to measure dynamic tongue function for diagnostic, therapeutic and research purposes, is a suitable technique for the evaluation of MFT.
This prospective clinical study assessed the effect of tongue re-education therapy on tongue function and dento-facial form in AOB patients.
Electropalatography recordings of speech and swallowing, and lateral head cephalometric radiographs were obtained from eight l0 -year-old boys with tongue-thrust swallowing behaviour and AOB before and after a course of tongue re-education therapy.
Although differences in cephalometric measurements before and after therapy were small, there was some evidence of a trend for upper and lower incisor eruption, with concomitant reduction of the AOB. Analysis of the EPG speech data was inconclusive, but the swallowing data showed trends for more consistent and more anterior patterns of EPG contact after therapy. Comparison of pre- and post-therapy EPG data with data from a parallel study using a group of age-matched controls indicated that some “normalisation” of swallowing behaviour had occurred. The results of this research imply that the therapy was partially successful in improving tongue function during swallowing and in reducing AOB.
Further research on a larger sample over a longer observation period is required for more accurate assessment of soft and hard tissue changes.