bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authentication of Wax Apple (Syzygium samarangense (Blume) Merr. & L.M Perry) Delima and Citra Cultivars by Morphological and Molecular Approach
Authors: Mukaromah Arnia Sari , Ulfah Malia , Rachmah Annisa Nur , Arfan Muhammad Ramdhani , Kusumarini Niken , Febriana Asri 
Published: November 2023

Wax apple Delima and Citra Cultivars are two superior non-climacteric tropical fruit commodities from Demak Regency which have similar morphological characters but have different fruit characteristics. Identification wax apple cultivars from Demak regency using DNA barcoding approach has not been researched yet. The aims of this research are to analyze the morphological similarities of wax apple between Delima and Citra cultivars and to identify genetic variations of wax apple Delima and Citra using trnL-trnF intergenic spacer for molecularly authentication. The results shown that there were no differences in the environmental parameters of the wax apple two cultivated area in Demak Regency. According to the morphological approach, the Delima and Citra cultivars in Demak Regency were grouped separately into Delima and Citra clusters with a similarity index of 61.5% (Citra cultivars) and 60.5% (Delima cultivars) and separated based on the origin of their cultivation area. Genetic variations between wax apple Delima and Citra in Demak Regency consisted of deletions (9delA 17delA) and conserved P6 loop in all compared cultivars. The possibility of heteroplasmy R (A,G) found at 73 nucleotide number in Delima Betokan cultivar and Citra cultivars (Betokan and Jungpasir). Meanwhile, Delima Jungpasir cultivar is K (G,T). There were P8 stem-loops with different lengths between Delima cultivars (Betokan and Jungpasir) and the same length in Citra cultivars (Betokan and Jungpasir). Therefore, the trnL-trnF intergenic spacer has not been thoroughly used in wax apple Delima and Citra authentication due to the presence of a secondary structure which causes the loss of the electropherogram signal so that the nucleotide sequence cannot be read.
Determinant of corporate social responsibility in Islamic banking based on the Islamic social reporting index
Authors: Salsabilah Fanana Firdaus , Fitri Resfa 
Published: November 2023

Purpose - This study aims to determine the level of CSR comparison in sharia-compliant banking based on the Islamic Social Reporting Index indicators and analyze the factors influencing its disclosure.Method - This study is quantitative research using secondary data. Population of this study is 9 Islamic Banks in Indonesia in 2017-2021. The selection of samples in this study used purposive sampling. The data were analyzed using Panel Data regression analysis, Classic Assumption test, F-test, and T-test.Result - The results showed that two of the four variables thought to have an impact on ISR disclosure are found to have a significant impact. In contrast to leverage, which has a negative but considerable impact on ISR disclosure, company age has a positive and significant impact. The other two factors (profitability and company size) had less of an impact on ISR disclosure.Implication - Islamic Commercial Banks in Indonesia suggest to improve the financial performance in Corporate Social Responsibility with Isamic Social Reporting Index.Originality - This is a study to prove the effect of corporate social responsibility disclosure on the annual report of Islamic banks using the Islamic Social Reporting Index indicator.
Pacta Sunt Servanda: Legal Dynamics in Indonesian Context
Authors: Cahyo Yoga Tri , Kurnianingsih Marisa 
Published: November 2023

This article discusses the role of the Pacta Sunt Servanda principle in loan agreements, particularly in the context of a court decision related to the breach of contract by PT BPR Suryamas Surakarta. The principle asserts that an agreement is binding as law to the parties involved and is utilized by judges as a consideration in court. The article aims to analyze the correlation of this principle with the judge's considerations in the context of breach of contract and evaluate the judge's perspective from the standpoint of legal utility. The research employs a normative juridical method through a literature review, using secondary data such as legal regulations and relevant literature. The results indicate that the Pacta Sunt Servanda principle plays a crucial role as a basis for judicial consideration, evident in the court decision that punishes the defendants according to the agreed-upon contract. While legal certainty predominates, the happiness of the parties involved, and the public is also a consideration for the judge. This decision, though emphasizing legal certainty, essentially contributes to the happiness of all parties involved and the community. Artikel ini mendiskusikan peran Asas Pacta Sunt Servanda dalam perjanjian pinjam meminjam, terutama dalam konteks putusan hakim terkait wanprestasi PT BPR Suryamas Surakarta. Asas ini menegaskan bahwa perjanjian berlaku sebagai undang-undang bagi pihak yang membuatnya, dan digunakan oleh hakim sebagai pertimbangan dalam pengadilan. Artikel bertujuan menganalisis korelasi asas tersebut dengan pertimbangan hakim dalam konteks wanprestasi, serta mengevaluasi pertimbangan hakim dari perspektif kemanfaatan hukum. Metode yang digunakan adalah yuridis normatif melalui studi kepustakaan, dengan data sekunder berupa peraturan perundang-undangan dan literatur terkait. Hasilnya menunjukkan bahwa Asas Pacta Sunt Servanda memiliki peranan penting sebagai dasar pertimbangan hakim, tergambar dalam amar putusan yang menghukum tergugat sesuai perjanjian. Meskipun aspek kepastian hukum mendominasi, kebahagiaan pihak terlibat dan masyarakat secara umum juga menjadi pertimbangan hakim. Putusan ini, meskipun lebih menonjolkan kepastian hukum, pada intinya menciptakan kebahagiaan bagi semua pihak terlibat dan masyarakat.
A Comprehensive Review on Drug Therapies and Nanomaterials used in
Orthodontic Treatment
Authors: Chauhan Nitasha , Kumar Mohit , Chaurasia Simran , Garg Yogesh , Chopra Shruti , Bhatia Amit 
Published: November 2023

Abstract:
Orthodontic treatment typically requires an extended duration of 1-2 years to complete the treatment.
Accelerating the rate of tooth movement during orthodontic treatment is essential for shortening the
overall treatment duration. After the completion of orthodontic treatment, a prominent concern arises in the
form of orthodontic relapse, where the teeth tend to revert to their original positions. This issue affects approximately
60% of the global population, underscoring the importance of implementing effective measures to address
orthodontic relapse. An approach in this regard involves the targeted administration of herbal and synthetic
drugs applied directly to the specific area of interest to facilitate tooth movement and prevent orthodontic
relapse. Apart from this, researchers are investigating the feasibility of utilizing different types of nanoparticles
to improve the process of orthodontic tooth movement. In recent years, there has been a noticeable increase
in the number of studies examining the effects of various drugs on orthodontics. However, the currently
available literature does not provide significant evidence relating to orthodontic tooth movement. In this review,
the authors provide valuable information about the drugs and nanomaterials that are capable of further
enhancing the rate of orthodontic tooth movement and reducing the risk of orthodontic relapse. However, a
notable hurdle remains, i.e., there is no marketed formulation available that can enhance orthodontic tooth
movement and reduce treatment time. Therefore, researchers should try herbal-synthetic approaches to achieve
a synergistic effect that can enhance orthodontic tooth movement. In this nutshell, there is an urgent need to develop
a non-invasive, patient-compliant, and cost-effective formulation that will provide quality treatment and
ultimately reduce the treatment time. Another critical issue is orthodontic relapse, which can be addressed by
employing drugs that slow down osteoclastogenesis, thereby preventing tooth movement after treatment. Nevertheless,
extensive research is still required to overcome this challenge in the future.
Drug-containing Serum of Quyoufang Promotes Apoptosis of Ectocervical H8 Cells through an E6/p53-related Pathway
Authors: Huang Shan , Chen Xiaofeng , Qi Yuanjie , Xiao Jing 
Published: November 2023

Background:
Persistent human papillomavirus (HPV) infection is a causative agent for
the majority of cervical cancer cases. The traditional Chinese medicine formula Quyoufang (QYF),
a herbal oral decoction therapy, has been widely applied in the treatment of various diseases caused
by HPV infection, but the molecular mechanism of QYF in the treatment of HPV infection remains
unclear. This study aimed to investigate the effect of drug-containing serum of QYF on the apoptosis
of HPV16-positive cervical immortalized epithelial cell line H8 in vitro.

Methods:
Different concentrations of medicated serum were obtained by feeding QYF into the
stomachs of rats. The effects of medicated serum on H8 cell proliferation and apoptosis were detected
using the cell counting kit-8 assay (CCK-8) method, flow cytometry, and Hoechst 33342/PI
apoptosis assays. The different expressions of E6, E7, p53, and pRb among H8 cells were detected
by RT-PCR and Western Blot.

Results:
The results firstly indicated that the drug-containing serum of QYF induced apoptosis
and suppressed the proliferation of H8 cells in a concentration-dependent manner. RT-PCR and
Western Blot unveiled that in contrast to the control group, the QYF groups could markedly elevate
the mRNA expression of P53 and pRb as well as promote the expression of p53 and pRb
protein levels. The QYF groups suppressed the expression of E6 mRNA and inhibited the expression
of E6 protein.

Conclusion:
The drug-containing serum of QYF could effectively inhibit the proliferation of H8
cells and induce their apoptosis, possibly through the E6/p53-related pathway
A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing
Ulcers - Case Series
Authors: Singh Sarabpreet , Aggarwal Arun Kumar , Gudisa Rajendra , Batra Priyam , Rathi Nitesh Kumar , Madan Vibha , Thakur Vipul , Sharma Harish , Kumar Rajesh , Khare Siddhant , Singhal Lipika , Chaudhry Rama , Arora Neeraj , Singh Hardeep , Kaur Jasjeet , Sharma Ashish , Dakhale Ganesh N. , Sharma Vijay , Gautam Vikas 
Published: November 2023

Introduction::
Appropriate care and treatment of a wound is the need of the hour whether it
is an infected or a non-infected wound. If wound healing is delayed for some reason, it leads to serious
complications and further increases the hospital stay and cost of treatment. Herein, we describe a
novel antimicrobial wound dressing formulation (VG111), with an objective to generate the preliminary
data showing the distinct advantages in various types of wounds.

Method::
This case series involved the treatment of acute cases of wounds or chronic wounds that did
not respond well to conventional wound healing treatments with VG111 in patients with different
etiologies. Thirteen cases of patients that included patients with diabetes, pressure ulcers, burns,
trauma, and others treated with VG111 showed rapid wound healing in all the cases even obviating
the need for a graft when complete skin regeneration occurred.

Result::
This was illustrated by clearing of the wound infections, reduction/disappearance of the exudate,
appearance of intense granulation, epithelialization, and anti-biofilm activity followed by complete
wound closure. This VG111 precludes the need for systemic antimicrobial agents in localized
infections and therefore, this single agent is an attempt to address the limitations and the drawbacks
of the available products.

Conclusion::
Despite patients belonging to the old age group and having comorbidities like diabetes,
still VG111 showed effective rapid wound healing, and that too without any scar formation in hardto-
heal, infected, and non-infected wounds.
Effect of Low Heat Steam Sterilization on the Volumetric Stability of Three Different 3D Printing Materials for Dental Implant Surgical Templates: An in vitro Study
Authors: Tachmatzidis Theodoros , Fotopoulos Ioannis , Lillis Theodoros , Kapagiannidis Ioannis , Dabarakis Nikolaos 
Published: November 2023

Background:
Computer-guided surgical templates are considered critical instruments and are proposed to be sterilized before surgery. However, steam heat sterilization process may result in volumetric changes in the acrylic resin materials and this may compromise the accuracy of the drilling process during surgery.

Objective:
The aim of this in vitro study was to investigate the effect of steam heat sterilization on the volumetric and morphological dimensions of 3D printed surgical guides that could affect the accuracy of guided implant surgery.

Methods:
A total of fifteen templates of the same size and shape were printed from three different resin materials (five templates from each material) based on digital data of a clinical case previously planned with a special implant planning software. Following the printing procedure, all templates were digitally scanned using an intraoral scanner before and after steam heat sterilization at 121°C for 20 minutes. The scan data were saved in STL files and volumetric and morphological changes were evaluated before and after sterilization process by using appropriate software. Results: The results showed dimensional alterations within the three tested materials, before and after the sterilization process. Mean percentage of volumetric change was -1.53% for Visijet, 0.50% for MED610 and 1.9% for eResin. A larger deformation of the surgical guides at the sleeve and buccal wire areas was also observed.

Conclusion:
We can conclude that low steam heat sterilization seems to affect differently the three investigated implant template materials. Visijet and eResin showed a significant difference between the initial and the final volume of the surgical guides. This could possibly decrease the accuracy of computer guided surgery.
Preparation and Evaluation of Chitosan Nanoparticles containing Iranian Eschium Amoenum Extract and its Antimicrobial Effects on Common Oral Microorganisms
Authors: Barzegar Farshad , Bohlouli Sepideh , Fakhri Elaheh , Dizaj Solmaz Maleki , Memar Mohammad Yousef , Sobhanifar Fatemeh 
Published: November 2023

Background and Aim:Chitosan nanoparticles are one of the biocompatible and bioactive vectors in medicine contributing to the transfer and slow release of antimicrobial agents. The present study investigated loadingEchium amoenumextract on chitosan nanoparticles and evaluated the antimicrobial effects of this composite onStreptococcus mutans,Candida albicans, andEscherichia coli.Materials and Methods:First, a chitosan solution was prepared in 1% acetic acid. Then, a tripolyphosphate (TPP) solution was added to it. The resulting mixture was centrifuged, and finally, its powder was dried. TheE. amoenumextract was prepared and added to the chitosan powder. After mixing, the mixture was centrifuged, and the chitosan nanoparticle powder containingE. amoenumwas separated and dried. The properties and characteristics of the nanoparticles were determined by the DLS test, and their stability was evaluated using the zeta potential. Finally, the antimicrobial effect of this product was evaluated onS. mutans,E. coli, andC. albicansusing MIC and MBC through the microdilution method.Results:The sizes of chitosan nanoparticles and chitosan nanoparticles containing the plant extract were 98±1.24 and 108±1.54 nm and their zeta potentials were +17 and +10, respectively. The MIC for chitosan, the extract, and chitosan nanoparticles containingE. amoenumextract forE. coliwere 170.67, 666.67, and 341.34 mg/mL; these values forS. mutanswere 106.67, 416.67, and 170.67 mg/mL, with 426.67, 1000, and 341.34 mg/mL forC. albicans, respectively. The MBC for chitosan, the extract, and chitosan nanoparticles containingE. amoenumextract forE. coliwere 426.67, 1666.67, and 853.34 mg/mL; these values forS. mutanswere 426.67, 833.34, and 426.67 mg/mL, with 853.34, 1666.67, and 853.34 mg/mL forC. albicans, respectively.Conclusion:Chitosan nanoparticles are an efficient vector forE. amoenumextract and loaded chitosan nanoparticles can be used as a bioactive antibacterial agent against various oral microorganisms.
Personalized 125I Seed Interstitial Brachytherapy for Patients Aged
80 Years and Over with Early Primary High-risk Non-melanoma Skin
Cancer
Authors: Yansong Liang , Juan Wang , Hongtao Zhang , Zezhou Liu , Xiaohua Su , Huanfen Zhao , Rongmei Zhao , Jianqi Yin 
Published: November 2023

Objective:
The aim of this study is to explore the safety and efficacy of iodine-125
seeds interstitial brachytherapy (PISI-BT) for patients aged 80 and above with early primary
high-risk non-melanoma skin cancer (NMSC).

Methods:
In this retrospective single-center study, we collected and analyzed data from patients
≥ 80 years of age with early primary high-risk NMSC treated with PISI-BT between December
2003 and May 2020. Survival status, efficacy, adverse effects (AEs), cosmetic outcomes, and
treatment cost were analyzed (data cut-off: November 20th, 2021).

Results:
Only 9 patients met the inclusion criteria (median age, 86 years (81-90)). Five patients
had an Eastern Cooperative Oncology Group (ECOG) score of 1, and allthe patients had at least
one comorbidity. Six patients showed complete responseand three showed partial response,
while none had stable or progressive disease. No recurrences, disease persistence, or AEs were
detected during the follow-up period. After a median follow-up of 29.3 months (3-99), only two
patients were alive, but the cause of death in the remaining patients was not related to NMSC.
The cosmetic outcomes were excellent and good in two and four patients, respectively, while
could not be evaluated in three patients. The cost (which was within the scope of medical insurance
reimbursement) was acceptable.

Conclusion:
PISI-BT could be an alternative treatment option in patients above 80 years old
with early primary high-risk NMSC and comorbidities.
Birth Order and its Effect on Children’s Dental Anxiety and Behavior during Dental Treatment
Authors: Alabdullatif Mujtaba Mohammed , Sabbagh Heba Jafar , Aldosari Fawziah Musaad , Farsi Najat Mohammed 
Published: November 2023

Objectives:
To investigate the association between dental anxiety and birth order among children seeking dental treatment at King Abdulaziz University Dental Hospital, Jeddah, Saudi Arabia.

Methods:
A total sample of 306 children aged 6-12 years were enrolled in a cross-sectional descriptive study. Demographic background data on the family and childbirth order were collected using a validated questionnaire. The Abeer dental anxiety scale (ADAS) was used to assess the dental anxiety level, while the Frankl scale was used to assess behavior during dental treatment. Binary Regression analysis was carried out to evaluate the effect of sociodemographic factors on the child’s anxiety and behavior according to the ADAS and Frankl scale, respectively.

Results:
The childbirth order had a significant effect on the anxiety score (
p<0.0001). The ADAS score in middle-born children was statistically significantly lower than that of only children, first-borns and last-borns (
p=0.018). Further, there was a statistically significant effect of childbirth order on behavior according to the Frankl scale (
p<0.0001).

Conclusion:
The presence of siblings and childbirth order are significant indicators of children’s behavior and anxiety during dental treatment. This study provides valuable information that can help pediatric dentists plan behavior management for children.
Dental Implant Treatment in Medically Compromised Patients: A Narrative Review
Authors: Hedari Donya Jalil , Kukreja Bhavna Jha , Ramachandra Srinivas Sulugodu , Reddy Sesha , D’souza Jovita , Abdelmagyd Hossam 
Published: November 2023

Background:
In terms of health treatment and subjects, dental implants have evolved as a standard therapy to solve different complications regarding the retention and stability of dentures for edentulous patients. Although dental implant techniques have been utilized in medically compromised patients, scientific evidence is unclear on the feasibility of implants among these patients. Adequate planning and precautions should be exercised as risks are enhanced among these patients.

Objective:
The primary objective of this work was to provide a brief overview of contraindications, precautions, and guidelines for the use of dental implants among medically compromised patients.

Methodology:
A literature search was performed for published articles within the range 2011-2021 published in English in PubMed, Medline, and OVID Medline databases using the terms Dental Implants, medically compromised patients, treatment plan, and implant survival.

Results:
A total of 23 studies were assessed. There are several studies that have mentioned radiotherapy as a critical risk factor “associated with the frequency of dental implant loss.” On the other hand, it has illustrated that metabolic changes have mainly occurred in diabetic patients. It has been determined that implant survival can be lower in a few disorders. Additionally, risks and complications among medically compromised patients have been noted.

Conclusion:
The study suggests that the psychosocial and functional benefits of an “implant restoration ” are the documented relative risks related to the common medical condition as well as their respective treatments. The assessment of the overall risk factors with the patient's education about the risk needs to be done in order to make perfect intervention strategies.
Shortening food supply chain in home-grown school feeding: experiences and lessons from south central China
Authors: Liu Xinghua , Liu Chengfang , Bi Jieying 
Published: November 2023

Abstract
Both home-grown school feeding (HGSF) and short food supply chain (SFSC) emphasize on proximity and aim to strengthen the competitiveness of local smallholder farmers. From a theoretical perspective, HGSF implemented as a type of SFSC could help deliver synergies. A pivotal question is how HGSF can be combined with SFSC and the benefits and drawbacks of such combination. Using an HGSF program which was implemented as an integral part of a free preschool lunch pilot in South Central China, this paper shows that HGSF and SFSC (in its full term) could be combined through one structured demand intervention. This study uses both qualitative and quantitative materials. Qualitative data were collected through focus group discussions with government and preschool staff, parents or caregivers, cooks, World Food Programme representatives and other stakeholders involved in the pilot program. The quantitative part used both small panel data and cross-sectional data from 106 smallholders. This study analyzes the design, implementation, good practices, benefits and constraints of the HGSF-SFSC model. We find that direct purchase from smallholder farmers was linked with higher income and production and dietary diversity. Moreover, this study identifies several constraints of the current HGSF-SFSC model. The policy implications for sustaining and scaling up the current pilot are discussed in the paper.