bluuebunny/crossref_metadata_2025_split huggingface dataset:
Система автоматизації пошуку місць для паркування
Authors: Нападій О. , Цьопа Н. , Батрак Є. 
Published: December 2023

У статті досліджуються перспективи використання системи автоматизації, пошуку місць паркування. Дана система спрямована на вирішення проблем, з якими стикаються водії під час пошуку вільних місць для паркування, особливо в багатолюдних міських районах поблизу житлових будинків або торгових центрів. В результаті комплексного огляду літератури та аналізу проблем було виявлено існуючі недоліки, пов’язані з традиційними методами пошуку місць для паркування: їх локалізований масштаб і фрагментарний характер. Стаття продовжує аналіз існуючих рішень, досліджуючи такі відомі на сьогодні мобільні додатки, як ParkMobile і SpotHero, системи на основі сенсорів і IoT, а також інтегровані технології паркування. Також наведено вичерпний огляд технології, на яких базуються системи даного типу GPS, аналіз даних у реальному часі та мережі датчиків для спрощення паркування. В результаті проведених досліджень та аналізу було визначено новаторський потенціал систем автоматизації для покращення управління паркуванням в міських районах. Здатність технології оптимізувати використання місць для паркування та загалом весь процес паркування а також підвищити загальну міську мобільність. Запропонована система автоматизації, як альтернативний варіант пошуку місць для паркування, показала високу точність прогнозування наявності вільних місць, надаючи водіям інформацію в реальному часі для прийняття обґрунтованих рішень.Попередня оцінка роботи системи проводилась на основі відгуків користувачів і показала непогані результати та подальші шляхи удосконалення запропонованого рішення. Крім того, можливості інтеграції системи та зручний інтерфейс забезпечують безпроблемне та зручне паркування у багатолюдних районах житлових масивів міста.
Бібл. 6, іл. 4, табл. 3
Pengaruh Pemberian Ekstrak Buah Mengkudu (Morinda citrifolia Linn) terhadap Respon Inflamasi Tikus yang diinduksi Kolitis
Authors: Utami Tri Fitri Yana , Sahid Muhammad Novrizal Abdi , Ediati Ediati , Sari Ika Puspita 
Published: December 2023

Kolitis Ulseratif (KU) merupakan penyakit peradangan usus yang dapat berkembang menjadi kanker usus dan akan meningkatkan kematian jika tidak tertangani dengan baik. Pengobatan KU dilakukan dengan pemberian kortikosteroid, imunosupresan dan agen biologis, namun hal itu dapat menyebabkan munculnya penyakit lainnya. Mengkudu (<em>Morinda citrifolia </em>Linn) mengandung senyawa flavonoid yang mampu memberikan efek preventif dan terapeutik dengan menurunkan sitokin proinflamasi sehingga diperkirakan dapat memperbaiki kondisi KU. Penelitian ini bertujuan untuk mengetahui efek pemberian Ekstrak Buah Mengkudu (EBM) terhadap KU pada tikus yang diinduksi asam asetat. EBM diperoleh dari ekstraksi metode maserasi menggunakan pelarut etanol 70%. Induksi KU dilakukan pada tikus <em>Sprague Dawley</em> menggunakan 2% asam asetat<span style="text-decoration: line-through;">.</span> Tikus dibagi menjadi 6 kelompok, yaitu: K1 (kontrol normal); K2 (kontrol negatif); K3 (Kontrol positif); K4, K5 dan K6 yaitu perlakuan berturut-turut diberi EBM dosis 100 mg/kgBB, 200 mg/kgBB dan 400 mg/kgBB. Kemudian dilakukan pengamatan respon inflamasi dengan paramater skoring penilaian indeks aktivitas penyakit (IAP) kolitis (berat badan, konsistensi feses, dan keberadaan darah pada feses), makrokopi lesi kolon serta rasio berat kolon/panjang kolon. Hasil penelitian ini menunjukkan bahwa EBM berpengaruh pada penurunan skor IAP KU, makroskopi lesi kolon dan rasio berat kolon/ panjang kolon pada dosis 100 mg/kgBB, 200 mg/kgBB, dan 400 mg/kgBB dimana dosis 400 mg/kgBB menunjukkan aktivitas yang lebih baik dan menunjukkan perbedaan siginifikan (p&lt;0,05) dibandingkan kontrol negatif. EBM memberikan respon yang baik pada kondisi KU jika dinilai dengan parameter tersebut. Perbaikan respon inflamasi pada KU oleh EBM, menjadikan EBM sebagai kandidat pengobatan KU yang potensial.
APPLICATION OF FENTON'S HETEROGENEOUS SYSTEM FOR THE TREATMENT OF ORGANIC-CONTAINING WASTEWATER
Authors: Kurylets O. H. , Makido O. Yu. , Khovanets’ G. I. , Vasiychuk V. O. 
Published: December 2023

With the growth of the Earth's population, the problem of the shortage of clean water is becoming global. And for the survival of humanity, it is necessary to significantly reduce the amount of harmful wastewater that pollutes the environment. Wastewater polluted with organic substances, usually produced by the production of dyes and the food industry, causes great damage to the environment.
The expediency of catalytic oxidation for the treatment of organic-containing effluents has been theoretically substantiated. As a catalyst, it is proposed to use new nanostructured composites of the «core-shell» type based on transition metal oxides (CoFe2O4/SiO2/CuO) for the Fenton system. The oxidizing agent in this system is H2O2, which is used in «green technologies».
It was investigated that the degree of destruction of the dye methylene blue (MB) depends on the composition of the catalyst, the ratio of the concentrations of the catalyst and dye, and the presence of a preliminary stage of dye adsorption.
The investigated catalyst was tested on simulated dairy wastewater (SDW). The research was carried out in a barbotage-type apparatus (Schott filter). For the system «dairy wastewater – CoFe2O4/SiO2/CuO – О2– Н2О2», the degree of dairy wastewater treatment is 63 %, and residual COD value is 39,52 mgO2/dm3. It was established that in the process of purification by the CoFe2O4/SiO2/CuO catalyst, active oxidizing compounds are formed, which significantly intensify the process.
Thus, there are reasons to assert that the prospect of developing a highly efficient catalytic oxidation technology in the Fenton system for the treatment of wastewater containing organic pollutants. And the results obtained and the conclusions drawn about the technological feasibility of using CoFe2O4/SiO2/CuO as a catalyst can find practical application for the implementation of technological schemes closed behind water and in other wastewater treatment technologies, in particular food production.
ANALYTICAL REVIEW OF MODERN NON-CONVENTIONAL ENERGY SOURCES
Authors: Selikhov Yu. A. , Gorbunov K. A. , Samoilov A. V. , Stasov V. A. 
Published: December 2023

The structure of the world energy economy has developed in such a way that 80 % of the electricity consumed is obtained by burning fuel at power plants, where the chemical energy of the fuel is first converted into heat, heat into work, and work into electricity. Hydropower also provides a significant percentage (about 15 %), the rest is covered by other sources, mainly nuclear power plants. Human needs are growing, there are more and more people, and this causes gigantic volumes of energy production and growth rates of its consumption. Today, traditional energy sources (various fuels, hydro resources) and technologies for their use are no longer able to provide the required level of energy availability of society, because these are non-renewable sources. And although the explored reserves of natural fuels are very large, the problem of depletion of natural reserves at the current and projected rates of their development is moving into a real and near future. Even today, a number of fields, due to depletion, turn out to be unsuitable for industrial development, and for oil and gas, for example, one has to go to hard-to-reach, remote territories, to ocean shelves, etc. The forecast proves that while maintaining the current volumes and growth rates of energy consumption at 5–7 %, fossil fuel reserves will completely run out in 70–150 years. Another factor limiting a significant increase in energy production through fuel combustion is the ever-increasing environmental pollution from energy production waste. These wastes are significant in mass and contain a large number of various harmful components. This is where acid rain comes from, the disappearance of ozone, the poisoning of farmland and water bodies. Moreover, nature is no longer able to process these pollution and self-repair by natural physico-chemical and microbiological methods.
In nuclear power, environmental problems of a different kind arise. They are associated with the need to exclude the ingress of nuclear fuel into the environment and the reliable disposal of nuclear waste, which, with the current level of development of technology and technology, is associated with great difficulties.
No less harmful is the thermal pollution of the environment, which can lead to global warming of the Earth's climate, melting of glaciers and rising sea levels.
In the light of the above, the widespread practical use of non-traditional and renewable energy sources, which are also environmentally friendly and do not pollute the environment, is becoming increasingly relevant.
The article briefly presents an analytical review of modern non-traditional and renewable energy sources.
Foxo3 Regulates the Homeostasis and Function of Thymic Epithelial Cells.
Authors: Alves Nuno , Ribeiro Camila , Ferreirinha Pedro , Landry Jonathan , Macedo Fátima , Sousa Laura , Pinto Rute , Benes Vladimir 
Published: December 2023

Abstract

Within the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T-cell development and selection. Considering that TECs are sensitive to distinct pathophysiological conditions, uncovering the molecular elements that coordinate their thymopoietic role has important fundamental and clinical implications. Particularly, medullary thymic epithelial cells (mTECs) play a crucial role in central tolerance. Our previous studies, along with others, suggest that mTECs depend on molecular factors linked to genome-protecting pathways, but the precise mechanisms underlying their function remain unknown. These observations led us to examine the role of Foxo3, as it is expressed in TECs and involved in DNA damage response. Our findings show that mice with TEC-specific deletion of Foxo3 (Foxo3cKO) displayed a disrupted mTEC compartment, with a more profound impact on the numbers of CCL21+ and thymic tuft mTEClo subsets. Notably, the combined deficiency in Foxo3 and Aire revealed a central role of Foxo3 in regulating Aire-dependent and Aire-independent mTEC lineages. At the molecular level, Foxo3 controls distinct functional modules in the transcriptome of cTEC and mTEC under normal conditions, which includes the regulation of ribosomal biogenesis and DNA damage response, respectively. These changes in the TEC compartment resulted in a reduced total thymocyte cellularity and specific changes in regulatory T cell and iNKT cell development in the Foxo3cKO thymus. Lastly, the thymic defects observed in adulthood extended to the periphery, as aged Foxo3cKO mice presented moderate signs of altered peripheral immunotolerance, which were aggravated in the Aire-deficient autoimmune background. Our findings highlight the importance of Foxo3 in preserving the homeostasis of TECs and in supporting their role in T-cell development and tolerance.
WITHDRAWN: Low Noise Amplifier and Local Oscillator Design and Manufacturing of Radio Telescope Receivers Using Planar Technology for Radio Astronomy Applications
Authors: Mchaalia Raja , Mejri Fethi , Aguili Taoufik 
Published: December 2023

Abstract
The purpose of this study is to develop and produce electronic components like as amplifiers, mixers, antennas, and so on for a radio telescope receiver that will detect hydrogen lines in our galaxy. Furthermore, the design of an RF receiver system requires careful consideration of the projected performance of discrete devices such as the LNA (low noise amplifier) and LO (local oscillator), which are essential for the overall sensitivity of the receiver system.This task includes the design and fabrication of the LNA and LO. For the design of the LNA, we chose a MAR6-SM+ bipolar transistor, which has a low noise figure and a high gain. The LNA and LO measurement findings correspond well with the frequency of the Hydrogen-Lines. We also displayed the spectrum of the hydrogen lines.
Intramolecular Chalcogen Bonding Activated SuFEx Click Chemistry for Efficient Organic-Inorganic Linking
Authors: An Jie , Wang Minlong , Hou Jiaman , Wang Chao , Zhang Xiaohe , Du Ying , Dong Qixin , Wang Lijun , Ni Ke , Ren Fazheng 
Published: December 2023

Abstract

SuFEx click chemistry demonstrates remarkable molecular assembly capabilities. However, the effective utilization of alkyl sulfonyl fluoride hubs in SuFEx chemistry, particularly in reactions with alcohols and primary amines, presents considerable challenges. In this study, we pioneered an intramolecular chalcogen bonding activated SuFEx (S-SuFEx) click chemistry employing alkyl sulfonyl fluorides with γ-S as the activating group. The chalcogen bonding activated alkyl sulfonyl fluorides can react smoothly with phenols, alcohols, and amines, exhibiting superior reactivity compared to SO2F2. Excellent yields were achieved with all 74 tested substrates. Alkyl sulfonyl fluorides featuring γ-S can be effectively synthesized via the thiol-ene reaction between thiols and ethenesulfonyl fluoride (ESF), which equips S-SuFEx chemistry with the potent capability to link thiols and O, N-nucleophiles using ESF as the linker. Pioneering the application of S-SuFEx chemistry, we highlight its immense potential in organic-inorganic linking, considering the critical role of interfacial covalent bonding in material fabrication. The S-SuFEx hub 1c, incorporating a trialkoxy silane group was specifically designed and synthesized for organic-inorganic linking. We have demonstrated that, in a simple step, 1c efficiently anchors various organic compounds onto surfaces of inorganic materials, leading to the formation of functionalized surfaces with properties such as antibacterial activity, hydrophobicity, and fluorescence.
General-purpose machine-learned potential for 16 elemental metals and their alloys
Authors: Fan Zheyong , Song Keke , Zhao Rui , Liu Jiahui , Wang Yanzhou , Lindgren Eric , Wang Yong , Chen Shunda , Xu Ke , Liang Ting , Ying Penghua , Xu Nan , Zhao Zhiqiang , Shi Jiuyang , Wang Junjie , Lyu Shuang , Zeng Zezhu , Liang Shirong , Dong Haikuan , Sun Ligang , Chen Yue , Zhang Zhuhua , Guo Wanlin , Qian Ping , Sun Jian , Erhart Paul , Ala-Nissilä Tapio , Su Yanjing 
Published: December 2023

Abstract

Machine-learned potentials (MLPs) trained against quantum-mechanical reference data have demonstrated remarkable accuracy, surpassing empirical potentials.
However, the absence of readily available general-purpose MLPs encompassing a broad spectrum of elements and their alloys hampers the applications of MLPs in materials science.
In this study, we present a feasible approach for constructing a unified general-purpose MLP for numerous elements and showcase its capability by developing a model (UNEP-v1) for 16 elemental metals (Ag, Al, Au, Cr, Cu, Mg, Mo, Ni, Pb, Pd, Pt, Ta, Ti, V, W, Zr) and their diverse alloys.
To achieve a complete representation of the chemical space, we demonstrate that employing 16 one-component and 120 two-component systems suffices, thereby avoiding the enumeration of all 65535 possible combinations for training data generation.
Furthermore, we illustrate that systems with more components can be adequately represented as interpolation points in the descriptor space.
Our unified MLP exhibits superior performance across various physical properties as compared to the embedded-atom method potential, while maintaining computational efficiency.
It achieves a remarkable computational speed of 1.5 × 108 atom step / second in molecular dynamics simulations using eight 80-gigabyte A100 graphics cards, enabling simulations up to 100 million atoms.
We demonstrate the generality and high efficiency of the MLP in studying plasticity and primary radiation damage in the MoTaVW refractory high-entropy alloys, showcasing its potential in unraveling complex materials behavior.
This work represents a significant leap towards the construction of a unified general-purpose MLP encompassing the periodic table, with profound implications for materials research and computational science.
Enhancing Anti-Tumor Activity of CAR T Cells
Through FOXO1-Mediated Stemness and Mitochondrial Fitness
Authors: Ando Makoto , Kondo Taisuke , Nakagawara Kensuke , Mise-Omata Setsuko , Yoshimura Akihiko 
Published: December 2023

Abstract
Loss of stemness and mitochondrial dysfunction induced by chronic antigen stimulation represents formidable obstacles in chimeric antigen receptor (CAR) T cell therapy for solid tumors. However, the regulation of stemness and mitochondrial fitness in CAR T cells remains unclear. Here we found that short-term resting conditions with IL-7, CXCL12, and the pan-tyrosine kinase inhibitor, Dasatinib, could reprogram CAR T cells, which exhibit tonic signal-dependent exhaustion hallmarks, into stem-like CAR T cells through epigenetic remodeling and enhance mitochondrial metabolism, thereby resulting in augmented antitumor activity against solid tumors. We identified forkhead box protein O1 (FOXO1) as a critical regulator of the epigenetic and metabolic reprogramming as well as antitumor activity. Moreover, it was found that FOXO1WT overexpression led to enhanced mitochondrial metabolism, efficient CAR T cell expansion, and potent antitumor effects through epigenetic modifications. We demonstrated the central role of FOXO1 in both stemness and mitochondrial metabolism in CAR T cells. These findings suggest that regulating FOXO1 is a promising strategy for engineering CAR T cells to treat solid tumors.
Pressure-Driven Paradigm Shift: Unveiling Activation Volume Effects in Hybrid Organic-Inorganic Compounds
Authors: Sieradzki Adam , Nowok Andrzej , Sobczak Szymon , Roszak Kinga , Szeremeta Anna , Maczka Miroslaw , Katrusiak Andrzej , Pawlus Sebastian 
Published: December 2023

Abstract

Hybrid organic–inorganic perovskites (HOIPs) constitute fast-developing class of materials with wide application possibilities. In this study, we investigate two model derivatives of formate HOIPs, acetamidinium manganese(II) formate (AceMn) and formamidinium manganese(II) formate (FMDMn), employing an interdisciplinary approach that combines X-ray diffraction and dielectric spectroscopy under various temperature-pressure conditions. AceMn exhibits atypical pressure-induced structural transformations, including a remarkable phase over-compression exceeding 2 GPa and a phase transition from the ambient-pressure P21/n-symmetric phase II to the higher-symmetry Pbca-symmetric phase III. We have revealed a unique pressure-induced ordering of cage cations in FMDMn, which proceeds without altering the phase symmetry or increasing energy barriers, and its direct relationship with relaxation peak amplitude. Additionally, we have redefined the activation volume parameter and emphasized its role in regulating relaxation dynamics under pressure. Our results indicate that the observed pressure-induced phase transitions within the investigated temperature range result of the combined effect of strain and dynamic of the A-site cation. Our results offer valuable insights for future HOIP research and the design of electronic and optoelectronic devices.
The Prognostic and Predictive Significance of Perineural Invasion in Stage I to III Colon Cancer: A Propensity Score Matching-Based Analysis
Authors: Chu Chun-Hui , Lai I-Li , Jong Bor‐Kang , Chiang Sum-Fu , Tsai Wen‐Sy , Hsieh Pao‐Shiu , Yeh Chien-Yuh , You Jeng‐Fu 
Published: December 2023

Abstract

Background
Colorectal cancer (CRC) presents with varying prognoses, and identifying factors for predicting metastasis and outcomes is crucial. Perineural invasion (PNI) is a debated prognostic factor for CRC, particularly in stage I-III patients, but its role in guiding adjuvant chemotherapy for node-positive colon cancer remains uncertain.
Methods
We conducted a single-center study using data from the Colorectal Section Tumor Registry Database at Chang Gung Memorial Hospital, Taiwan. This prospective study involved 3,327 CRC patients, 1,536 of whom were eligible after application of the exclusion criteria, to investigate the prognostic value of PNI in stage I-III patients and its predictive value for node-positive/negative cancer patients receiving adjuvant chemotherapy. Propensity score matching (PSM) was used to minimize selection bias, and follow-up was performed with standardized procedures.
Results
PNI-positive (PNI+) tumors were associated with higher preoperative CEA levels and more frequent adjuvant chemotherapy. After PSM, PNI + tumors were associated with significantly lower 5-year disease-free survival (DFS) and overall survival (OS) rates in stages III CRC. However, no significant differences were observed in stages I and II. Subgroup analysis showed that among PNI + tumors, only poorly differentiated tumors had higher odds of recurrence. PNI did not predict outcomes in node-negative colon cancer. Adjuvant chemotherapy benefited PNI + patients with node-positive but not those with node-negative disease.
Conclusions
Our study indicates that PNI is an independent poor prognostic factor in stage III colon cancer but does not predict outcomes in node-negative disease. Given the potential adverse effects of adjuvant chemotherapy, our findings discourage its use in node-negative colon cancer when PNI is present.
Climate change contribution to the 2023 autumn temperature records in Austria
Authors: Laimighofer Johannes , Formayer Herbert 
Published: December 2023

Abstract
Global monthly mean temperature continuously breaks records in the year 2023 since June till October. This also happened widespread at September and October in Austria, but monthly temperature records on a local scale in the mid latitudes like Austria show less persistence than global or continental averages. This makes the autumn temperature extremes in Austria even more striking. Considering the compound occurrence of such an event at actual climate, results in a return period of 324 years, which makes it extraordinary itself. Considering climate change, the compound event of two consecutive extreme warm months of 2023 yield return periods of about 10 000 years until the second half of the 20th century, which partly exceeds the length of the Holocene. Focusing on moderate compound extremes of the last 10 years (2014 - 2023), these reach return periods of 100 years up to 1960, but are now likely to happen every 15 years. Compound extremes in summer (July and August) present a higher decrease of the return period in Vienna, possible leading to even more severe impacts on ecosystems and society.
Assessment of the oxidative stress intensity and the integrity of cell membranes under the manganese nanoparticles toxicity in wheat seedlings.
Authors: Sieprawska Apolonia , Rudolphi-Szydło Elżbieta , Skórka Magdalena , Telk Anna , Filek Maria 
Published: December 2023

Abstract
A response to manganese nanoparticles was studied in seedlings of two wheat cultivars and a model system of plant cell membranes. Nanoparticles at concentrations of 125 and 250 mg/ml were applied foliarly. The appliction of NPs enhanced the content of Mn in plant cells, indicating its penetration through the leaf surface. The stressful effect in the plant cells was estimated based on changes in the activity of antioxidant enzymes, content of chlorophylls and starch. MnNPs evoked no significant changes in the leaf morphology, however, an increase in enzyme activity, starch accumulation, and a decrease in chlorophyll synthesis indicated the stress occurrence. Moreover, a rise in the electrokinetic potential of the chloroplast membrane surface and the reconstruction of their hydrophobic parts toward an increase in fatty acid saturation was found.