bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far infrared radiation ameliorates non-alcoholic fatty liver disease in mice by activating AMPK
Authors: xu tianyi , Fu Haijing , zhao wumei , ye chenyan , Shan Shijun 
Published: December 2023

Abstract
Background & Aims:Non-alcoholic fatty liver disease (NAFLD) is a disease that causes an abnormal accumulation of fat in the liver, triggering inflammation and liver damage, the mechanism of which is not fully understood and for which there is a lack of specific drug therapy. Far infrared radiation (FIR) has demonstrated evident therapeutic efficacy across various diseases, and it can be emitted by novel nanomaterial graphene patches through electric heating. This study aimed to investigate the potential protective effects of FIR against NAFLD.
Methods: Mice were fed with MCD diet to mimic NAFLD progression, and the effect of FIR on NAFLD was assessed by histopathology analysis, biochemical analysis, RT-qPCR, and Western blotting analysis. The effect of FIR treatment on lipid deposition in hepatocytes was investigated by cell culture in vitro.
Results: Mice subjected to MCD diet and treated with FIR exhibited reduced hepatic lipid deposition, liver damage and inflammation. The therapeutic effect exerted by FIR in mice is most likely attributed to the enhancement of AMPK phosphorylation. Besides, FIR intervention alleviated lipid accumulation in hepatocytes in vitro.
Conclusion: Our results revealed a promising potential of FIR as a novel therapeutic approach for NAFLD.
Nascent Competition and Killer Acquisitions in Digital Markets: a Decade of Acquisitions by Big Tech
Authors: Lemos Thales de Melo e , Resende Guilherme Mendes 
Published: December 2023

Abstract

Acquisitions in digital markets by dominant companies such as Google, Apple, Facebook, Amazon and Microsoft (GAFAM) raise concerns related to the elimination of potential and nascent competition. While demands for merger control reforms in this segment are proliferating, there are still important controversies and insufficient systemic studies on the matter. Therefore, this study evaluates, based on theoretical and empirical research, the hypothesis that acquisitions of nascent competitors and killer acquisitions are not common enough in digital markets to justify drastic changes in merger control rules. To this end, we more rigorously define important terms, such as killer acquisitions and nascent competitors. Then we investigate and classify all acquisitions made by the GAFAM firms between 2009 and 2018, considering the targets’ ages, their main activities and whether they were shut down after acquisition. The results indicate that most acquisitions did not have a clear horizontal effect, meaning that GAFAM companies often purchase inputs, talents, or complementary products. However, the study identifies and examines in detail possible nascent competitors’ and killer acquisitions. The results indicate that antitrust authorities should be aware of the issue and undertake cautious reforms of merger control rules, balancing competition protection against the risks of unnecessarily harming innovation.JEL:[K21 – Antitrust Law] [L41 – Monopolization • Horizontal Anticompetitive Practices]
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
Authors: Smabers Lidwien Paula , Wensink Emerens , Verissimo Carla S. , Koedoot Esmee , Pitsa Katharina-Chara , Huismans Maarten Age , Barón Celia Higuera , Doorn Mayke , Iersel Liselot B. Valkenburg-van , Cirkel Geert Anne , Brousali Anneta , Overmeer René , Koopman Miriam , Braat Manon N. , de Vries Bas Penning , Elias Sjoerd G. , Vries Robert G. , Kranenburg Onno , Boj Sylvia F. , Roodhart Jeanine M. 
Published: December 2023

Abstract
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy. The aim of this study is to optimize PDO drug screening methods for correlation with patient response and explore the potential to predict responses to standard chemotherapies.Methods We optimized drug screen methods on 5–11 PDOs per condition of the complete set of 23 PDOs from patients treated for metastatic colorectal cancer (mCRC). PDOs were exposed to 5-fluorouracil (5-FU), irinotecan- and oxaliplatin-based chemotherapy. We compared medium with and without N-acetylcysteine (NAC), different read-outs and different combination treatment layouts to capture the strongest association with patient response. We expanded the screens using the optimized methods for all PDOs. Organoid sensitivity was correlated to the patient’s response, determined by % change in the size of target lesions. We assessed organoid sensitivity in relation to prior exposure to chemotherapy, mutational status and sidedness.Results Drug screen optimization involved excluding N-acetylcysteine from the medium and biphasic curve fitting for 5-FU & oxaliplatin combination screens. CellTiter-Glo measurements were comparable with CyQUANT and did not affect the correlation with patient response. Furthermore, the correlation improved with application of growth rate metrics, when 5-FU & oxaliplatin was screened in a ratio, and 5-FU & SN-38 using a fixed dose of SN-38. Area under the curve was the most robust drug response curve metric. After optimization, organoid and patient response showed a correlation coefficient of 0.58 for 5-FU (n = 6, 95% CI -0,44-0.95), 0.61 for irinotecan- (n = 10, 95% CI − .03-0.90) and 0.60 for oxaliplatin-based chemotherapy (n = 11, 95% CI -0.01-0.88). Median progression-free survival of patients with resistant PDOs to oxaliplatin-based chemotherapy was significantly shorter than sensitive PDOs (3.3 vs 10.9 months, p = 0.007). Increased resistance to 5-FU in patients with prior exposure to 5-FU/capecitabine was adequately reflected in PDOs (p = 0.005).Conclusions Our study emphasizes the critical impact of the screening methods for determining correlation between PDO drug screens and mCRC patient outcomes. Our 5-step optimization strategy provides a basis for future research on the clinical utility of PDO screens.
Clinical analysis of cervical cancer in the second and third trimesters of pregnancy
Authors: Chen Yali , Zou Juan , Han Lin , Wan Qi 
Published: December 2023

Abstract
Background
To explore the clinical and prognostic characteristics of patients with cervical cancer in late pregnancy, and provide guidance for clinical decision-making for both doctors and patients.
Methods
A retrospective analysis was conducted on the clinical data of 13 cases of cervical cancer in late pregnancy treated in our hospital from 2008 to March 2022.
Results
The average age of the patients was 33.54 ± 4.98 years old, with 5 cases diagnosed in late pregnancy and 8 cases in mid-pregnancy. The main clinical manifestation was vaginal bleeding, and cervical biopsy confirmed the diagnoses after the patients sought medical attention. Among them, 9 patients had HPV16 infection. Eight patients underwent chemotherapy during pregnancy, and all patients underwent cesarean section to end the pregnancy. Twelve patients underwent radical surgery during cesarean section, and 1 patient underwent surgical treatment after chemotherapy 6 weeks after cesarean section. Eventually, 11 patients gave birth, while 2 patients gave up on neonatal rescue. Among them 1 patient has developed VIN I, 1 patient is lost to follow-up, and 11 patients have been cured without recurrence.
Conclusion
HPV16 infection before pregnancy is a high-risk factor for cervical cancer during pregnancy, and vaginal bleeding during pregnancy should be taken seriously. The prognosis is good after treatment of cervical cancer in the second and third trimesters of pregnancy.
Comparison between two extraction methods of plant lectins from Ruta graveolens L. and their partial characterization
Authors: Alvarez Amairany Torres , García Laura Flores , Mendoza-V Ernesto , Machuca C. 
Published: December 2023

Abstract
Background:
Ruta graveolens L. is a plant wich has several uses among different communities, such as an anti inflammatory and antitumor, related to the plant lectins available in their different tissues.
Extraction of this molecules is achieved through diverse extraction methods, without knowledge about which one is better to preserve their native structure.
In this study two well- documented methods are compared.
Results:
Lectin-enriched extracts were obtained out of different R. graveolens L. organs, and those were purified trough NaCl salt extraction and Tris-HCl extraction methods. Additionally, several eluents were used in the affinity chromatography method.
Conclussion:
Lectin-like proteins with affinity to several carbohydrates were found. The NaCl extraction method was more efficient at extracting lectin-like proteins than the Tris-HCl method, comparing to the total-protein extract. These results suggest that Tris-HCl buffer is more efficient to extract other proteins.
Co-designing Entrustable Professional Activities in General Practitioner’s Training: a Participatory Research Study
Authors: Andreou Vasiliki , Peters Sanne , Eggermont Jan , Schoenmakers Birgitte 
Published: December 2023

Abstract
Background
In medical education, Entrustable Professional Activities (EPAs) have been gaining momentum for the last decade. Such novel educational interventions necessitate accommodating competing needs, those of curriculum designers, and those of users in practice, in order to be successfully implemented.
Methods
We employed a participatory research design, engaging diverse stakeholders in designing an EPA framework. This iterative approach allowed for continuous refinement of a framework with 62 EPAs. Our approach involved two iterative cycles. In the first cycle, we utilized a modified-Delphi methodology with clinical competence committee (CCC) members, asking them whether each EPA should be included. In the second cycle, we used semi-structured interviews with General Practitioner (GP) trainers and trainees to explore their perceptions about the framework and refine it accordingly.
Results
During the first cycle, 14 CCC members agreed that all the 62 EPAs should be included in the framework. Regarding the formulation of each EPAs, 20 comments were given and 16 adaptations were made to enhance clarity. In the second cycle, the semi-structured interviews with trainers and trainees echoed the same findings, emphasizing the need of the EPA framework for improving workplace-based assessment, and its relevance to real-world clinical scenarios. However, trainees and trainers expressed concerns regarding implementation challenges, such as the large number of EPAs to be assessed, and perception of EPAs as potentially high-stakes.
Conclusion
Accommodating competing stakeholders’ needs during the development process can significantly enhance the EPA implementation process. Recognizing users as experts in their own experiences empower them and enables identification of implementation barriers and potential pitfalls. By embracing a collaborative approach, wherein diverse stakeholders contribute their unique viewpoints, we can only create effective educational interventions to complex assessment challenges.
Determinant Factor of Women's Unemployment Status in Ethiopia Using Multilevel Analysis Approach
Authors: Hirbo Hirbo Geremew , Kuse Kenenisa Abdisa , Asnakew Alemnesh Mulugeta , Hola Roba Nebi , Wudu Tadele Kasahun 
Published: December 2023

Abstract
Background: Unemployment as a state in which, people who can work are without jobs and are seeking for pay or profit. Unemployment is one of the main challenges of the modern era in both developed and developing countries. Unemployment gives rise to private and social problems in the society such as increased crimes, suicides, poverty, alcoholism and prostitution. The main objective of this study was designed to describe the variation in unemployment among women in Ethiopia.
Methodology: The dataset for this study was taken from the EDHS 2016. The data included basic demographic and social characteristics. A Binary logistic regression model was used to estimate determinants of unemployment status. The Multilevel random coefficient model has a best-fitted model and estimates the variation of unemployment status across the regions of Ethiopia.
Results: A total of 15683 women were included in this study, among this study 10011(63.8% ) women are unemployed and 5672(36.2%) women are employed in Ethiopia. according to 2016 EDHS data. The results from the multilevel reveal that to the random coefficient model the variable Women education level ware secondary and above, parent education level ware primary, parent economic status was richest, women who reside urban, marital status ware separated, and the current age of women ware less than or equal to 25 years, less likely to be that the women were unemployed. While pregnancy women, Women's household size greater than 5 and where the Sex of the Head of Household is male were more likely to be unemployed. The effect of these significant variables is the same for each region in Ethiopia.
Conclusion: This study indicated significant evidence of variation among regions clusters and found that the variation within regions was much higher in regions. This study recommends that continued programmatic and policy initiatives should be directed to improve education levels as a means of improving women's unemployment.
Assessment on Factors That Affect the Cardiovascular Patients Using Cox Ph Model
Authors: Hirbo Hirbo Geremew , Kuse Kenenisa Abdisa , Hola Roba Nebi , Oromo Hankarso Harka 
Published: December 2023

Abstract

Background Heart and blood vessel disorders collectively are known as cardiovascular diseases, or CVDs. It is a serious global health issue, with low- and middle-income nations accounting for 82% of cardiovascular deaths. Because CVD risk factors are not effectively managed or prevented, these diseases disproportionately affect younger populations and cause premature mortality in developing nations like Ethiopia. The purpose of this study was to select suitable models and evaluate the factors influencing the survival of cardiovascular patients. Methods During a follow-up period, patients participated in this study. The study, which comprised patients taken from EDHS, Using EDHS data, a sizeable sample of 4712 patients was obtained for this investigation. R software was used to analyze survival data using semi-parametric survival models. Results Of the 4712 patients, 1760 (37.4%) were still alive at the end of the study period, and 2952 (62.6%) had passed away due to events or deaths. Cardiovascular disorders were very common. Patients with inappropriate use of risk factors such as alcohol and smoking have been found to have a higher prevalence of cardiovascular diseases. Conclusions This study found a significant correlation between cardiovascular diseases and blood pressure, smoking, being illiterate, and having diabetes. In order to inform policy and direct strategies and programmers for the prevention and control of these risk factors for the survival of cardiovascular patients, the health organization should be established in Ethiopia on a sentinel basis.
Operational Modal Analysis of a Suspension Bridge Using a Single Accelerometer: Simulation and Eigenfrequency Identification
Authors: Hamdi Faouzi 
Published: December 2023

Abstract
This study focuses on the practical implementation of Operational Modal Analysis (OMA) with a minimalistic sensor setup, utilizing only a single accelerometer for data acquisition. By employing simulation techniques, the paper explores the identification of eigenfrequencies, a key parameter describing the natural oscillation frequencies of the bridge. This innovative methodology offers valuable insights into the bridge's response to dynamic forces, contributing to a more cost-effective and streamlined approach to structural health monitoring. The paper addresses the inherent challenges and limitations associated with employing a single sensor, showcasing the potential of OMA in scenarios where resource constraints or practical considerations limit the use of multiple sensors. The findings contribute to the broader field of structural dynamics and modal analysis, offering a nuanced perspective on the dynamic characteristics of suspension bridges in real-world conditions.
AI as a Co-Engineer: A Case Study of ChatGPT in Software Lifecycle
Authors: Djaber ROUABHIA , Ismail HADJADJ 
Published: December 2023

Abstract
This case study investigates the application of AI in developing an E-commerce platform for shoe sales, focusing on the integration of OpenAI's ChatGPT into the software development lifecycle. By leveraging the GPT-4 model, the study introduces an innovative methodology that automates the creation of UML diagrams, code, UI prototypes, and database schemas. The findings indicate that AI significantly enhances efficiency and consistency while maintaining the quality of software artifacts. Although challenges in AI integration and interpretation were encountered, the study confirms AI's transformative role in software engineering. The research bridges the gap between theoretical AI capabilities and their practical implementation, offering insights for future enhancements in the field and establishing a methodological foundation for efficient, high-quality software development.
Reduced Complexity of Motion Estimation in Pixel Domain based on Rate Distortion Control
Authors: Singam Aamitesh Kumar , Pashike Venkat Raj Reddy , Shahid Muhammad 
Published: December 2023

Abstract

We concluded that Coding theory in terms of Estimation within Channel and Video coding within Network Architecture towards Quality Assessment within Networks through Vector Representation are two different Aspects which should be in included in standard recommendations. This two research aspects that rate distortion analysis should only be utilized for compression, not for quality estimation. Moreover correlation coefficient should not be considered in terms of mean square error. Our future work includes towards finding trade off between complexity of spatial and temporal correlation.
Exploration of the Benefits of Linking the Teaching and Learning of Geometry at the Senior High School to the Akan Cultural Practices
Authors: ATTA SETH AMOAKO 
Published: December 2023

Abstract
The purpose of the study was to investigate the paybacks of linking senior high school geometry to Akan cultural practice. The study area was the Ashanti region, which houses a chunk of the Akan people. The targeted population for the study included experienced mathematics teachers and people who are well-versed in Akan traditional art. Ten participants were recruited, including seven experienced mathematics teachers and three craftsmen, using purposive and snowball sampling methods. Data collection was conducted through interviews to elicit in-depth information from participants using a semi-structured interview guide. The data was analysed using thematic analysis. According to the analysis, teaching geometry with an Akan cultural perspective fosters conceptual understanding and raises academic achievement through lifelong learning. Secondary, it produces students who are patriotic and innovative, ready to face real-life challenges instead of becoming a burden on society. The researchers concluded that the Akan culture is embedded with concepts that are geometric, and it serves as good tool for teaching and learning geometry at the Senior High School
Neglected Venereal Infections: Analysis in the Context of Primary Care in a Community in the Municipality of Guanambi in the Course of 2023 Year
Authors: Pires Eisler Emanuelle Gomes , Martins Emanuele Prado , Batista Giovana Souza , Araújo Amanda de Oliveira , Silva João Augusto Saraiva , Souza Júlia Sâmi Melo e , Fraga Márjore Porto , Soares Victor Gabriel , Dias Felipe Teixeira 
Published: December 2023

Abstract
This article analyzed sexually transmitted infections (STIs) in the context of primary care in the Novo Horizonte neighborhood in Guanambi-BA, the risk factors and consequences for health and well-being. The objective was to analyze the occurrence of neglected venereal infections in the context of primary care in the Novo Horizonte neighborhood in the municipality of Guanambi over the course of 2023. The study adopts a deductive approach, using quantitative methods to assess the impact on communities. For the formulation and design of the research, a meticulous evaluation of the complexities underlying the data submitted to the Electronic Citizen Record (PEC) was carried out with an emphasis on data from the Novo Horizonte neighborhood community. The results showed that STIs are a public health problem that affects thousands of people throughout Brazil and a significant part of the population of Guanambi-BA. The research highlights the importance of continuous epidemiological surveillance and the implementation of accessible prevention and treatment strategies. It is hoped that this research will provide input for further research on the subject.
A Bibliometric Analysis Of Digital Dentistry
Authors: GÜLEK Eda , KUL Esra , YANIKOĞLU Nuran 
Published: December 2023

Aim: In this bibliometric analysis, the research trends of the researchers, institutions, countries, and journals that contributed to the study of digital dentistry were to be analyzed.
Materials and Methods: The Web of Science (WoS) database, which covers papers on digital dentistry between 2012 and 2022, served as the foundation for the literature search. Titles, abstracts, keywords, authors, connections, nations, and references are among the metadata that have been saved. Through the use of the Vosviewer software, the collected data were examined using bibliometric indicators for all interactions and collaborations.
Results: 254 studies that were published between 2012 and 2022 were identified using the bibliometric analysis through searches in the Web of Science database. Total citations for publications on digital dentistry were 2112, averaging 8.31 per article. The 25 H index was identified. These publications had an article document type at a rate of 82.66%. The Journal of Esthetic and Restorative Dentistry published the most articles on digital dentistry, while it also attracted the most citations.
Conclusions: The study on digital dentistry was expanding between 2012 and 2022. Extensive partnerships and citations between authors, institutions, and countries or regions have been observed as a result of the global expansion in digital dentistry research. In the upcoming years, it is anticipated that research on digital dentistry will continue to be popular. According to recent publications, the accuracy and precision of intraoral scanners, digital impressions, and the variations between different intraoral scanners have all become popular research topics.
La Intersección de las Relaciones Internacionales y la Movilidad Migrante: Una Perspectiva Estructuralista
Authors: Martínez Villanueva Claudia L. 
Published: December 2023

Las Relaciones Internacionales como disciplina han recibido cuestionamientos por su etnocentrismo y su naturaleza parroquial. A más de cien años de su nacimiento, la demanda de apertura en este campo es inminente, con la capacidad de reflejar problemáticas y fenómenos trasnacionales desde la inter y multidisciplinariedad y establecer una agenda renovada y amplia. La mirada hacia la movilidad migrante a partir de la disciplina daría una aproximación al análisis en el nivel “top-down” desde las estructuras del macro nivel que influencia a los Estados en la gestión migratoria. El objetivo del artículo, es presentar argumentos a favor de incorporar el estudio de la movilidad migrante desde la disciplina, y cómo desde la aproximación teórica neorrealista y el Análisis de los Sistemas – Mundo se puede comprender el fenómeno como un proceso histórico, sistémico y estructural.