bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Yang Berhubungan Dengan Status Kesehatan Pekerja Di Bagian Power Plant Ptpn XIV Pabrik Gula Camming
Authors: Irmalasari Fani , Muhammad Ikhtiar  , Ikhram Hardi S  
Published: February 2024

Kesehatan dan keselamatan masyarakat pekerja sangat terkait hubungannya dengan kesejahteraan dari pekerja itu sendiri. Perusahaan jelas ingin pekerja sehat, dikarenakan pekerja yang sehat akan menghasilkan pekerjaan yang lebih baik dibandingkan dengan pekerja yang kesehatannya terganggu. Masalah kesehatan juga kerap kali dikeluhkan pekerja PTPN XIV Pabrik Gula Camming. Berdasarkan hasil observasi, mesin-mesin produksi di PTPN XIV Pabrik Gula Camming aktif selama 24 jam pada saat penggulingan. Semua mesin aktif. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan status kesehatan pekerja di bagian Power plant PTPN XIV Pabrik Gula Camming. Sampel yang digunakan yaitu seluruh pekerja dibagian power plant PTPN XIV Pabrik Gula Camming sebanayak 21 pekerja. Penelitian ini menggunakan analisis univariat dan bivariate. Sedangkan pendekatan yang digunakan cross sectional dengan analisis chi-squere. Hasil penelitian menunjukkanTidak ada hubungan antara perilaku kerja dengan status kesehatan pekerja bagian Power Plant di PTPN XIV Pabrik Gula Camming dimana nila p= 0.09 > 0.05, kedua, Ada hubungan lingkungan kerja dengan status kesehatan pekerja bagian Power Plant di PTPN XIV Pabrik Gula Camming dimana nila p= 0.000 < 0.05. Dan terakhir Tidak ada hubungan antara layanan kesehatan dengan status kesehatan pekerja bagian Power Plant di PTPN XIV Pabrik Gula Camming dimana nila p= 0.223 > 0.05. Dari hasil penelitian ini, diharapkan pekerja yang status kesehatannya sehat untuk memperhatikan kembali gaya hidup atau sikapnya di lingkungan ataupun di luar lingkungan kerja.
Adolescent Pregnancy Outcome in a District Hospital of Bangladesh
Authors: Chowdhury Nowshafreen , Rahim Riffat , Khan Laila Nazneen , Sweety Kamrunnahar , Akther Pervin 
Published: February 2024

Background: Adolescent pregnancy is universally accepted as high risk pregnancy. Bangladesh has the highest (1 in 10) adolescent fertility rate in South Asia.
Objective: The study was conducted to find out the common problems of adolescent pregnancy.
Methodology: A comparative cross-sectional study was carried out among 100 respondents (50 adolescents and 50 adults) in Munshigonj General Hospital from 1st January to 31st December 2018. Respondents were admitted patients who have delivered either vaginally or by caesarian section. Women aged 15 to 19 years selected as adolescent and those aged 20 to 40 years selected as adult. Socio-demographic characteristics, past obstetric history, antenatal checkup, antenatal and intrapartum complications, and clinical state on admission were recorded in a semi structured questionnaire. Obstetrical parameters of adolescent and adult groups were compared.
Results: Among total admitted patients 11% were adolescent. 70% were from rural area, 68% were poor, 50% didn’t have even primary education, 92% adolescent never use contraceptive, 56% had no ANC. Anemia (62%) and hypertension (24%) were prevalent among the pregnant adolescents. Complication rate were more in adolescent group, like preeclampsia (12%), eclampsia (14%), preterm labor (12%), prolonged labor (14%), obstructed labor (8%). Caesarean rate was higher (66%) in adolescent pregnancy.
Conclusion: Majority of the adolescents had no ANC, complication rate were more prevalent in adolescent group. Adverse perinatal outcome was found in adolescent pregnancy.
Mugda Med Coll J. 2022; 5(2): 55-59
Determinants of Type 2 Diabetes Mellitus among Children and Adolescents Attending A Tertiary Specialized Hospital in Bangladesh
Authors: Tayyeb Samin , Zabeen Bedowra , Naz Farzana , Azad Kishwar 
Published: February 2024

Background: Type 2 diabetes in children and adolescents has increased in frequency around the world over the past two decades. The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of type 2 diabetes in children and adolescents.
Objective: To observe the determinants of type 2 diabetes mellitus among children and adolescents attending a tertiary specialized hospital in Bangladesh.
Methods: This cross-sectional, descriptive study was done on a total of 151 children and adolescents attending the pediatric diabetic outpatient department (OPD) of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine, and Metabolic Disorders (BIRDEM) Hospital, Dhaka, Bangladesh. The sampling technique was purposive. All patients who came to the hospital between July to December 2017 were included. Data was collected through a structured questionnaire.
Results: Among 151 respondents, 98 were in the age group of 10-14 years (64.9%), female to male ratio of 1.22:1. The majority belonged to a high used to lead socio-economic class. Regarding food habits, 55.6% had a history of eating fast food regularly and used to lead a sedentary lifestyle with a lack of exercise. 43.7% of children and adolescents were obese 76.8% had high cholesterol and 84.1% had high triglyceride levels. Most of the children had a positive family history of type 2 diabetes mellitus (74.8%).
Conclusion: Our study reflects that determinants like obesity, physical inactivity, eating habits, and family history are important factors in the development of type 2 diabetes mellitus in children and adolescents.
Mugda Med Coll J. 2023; 6(2): 51-56
A rapid VEGF-gene-sequence photoluminescence detector for osteoarthritis
Authors: Huang Hao , Li Shuang , Han Xianjing , Zhang Yule , Gao Lingfeng , Wang Xiangjiang , Wang Guiqing , Chen Zhi 
Published: February 2024

Osteoarthritis (OA) has become a serious problem to the human society for years due to its high economic burden, disability, pain, and severe impact on the patient’s lifestyle. The importance of current clinical imaging modalities in the assessment of the onset and progression of OA is well recognized by clinicians, but these modalities can only detect OA in the II stage with significant structural deterioration and clinical symptoms. Blood vessel formation induced by vascular endothelial growth factor (VEGF) occurs in the early stage and throughout the entire course of OA, enables VEGF relating gene sequence to act as a biomarker in the field of early diagnosis and monitoring of the disease. Here in, a facile rapid detection of VEGF relating ssDNA sequence was developed, in which manganese-based zeolitic imidazolate framework nanoparticles (Mn-ZIF-NPs) were synthesized by a simple coprecipitation strategy, followed by the introduction and surficial absorption of probe ssDNAs and the CRISPR/Cas12a system components. Furthermore, fluorescence experiments demonstrated that the biosensor displayed a low detection limit of 2.49 nM, a good linear response to the target ssDNA ranging from 10 nM to 500 nM, and the ability of distinguishing single nucleotide polymorphism. This finding opens a new window for the feasible and rapid detection of ssDNA molecules for the early diagnose of OA.
Microbial interventions in yak colibacillosis: Lactobacillus-mediated regulation of intestinal barrier
Authors: Zhang Jingbo , Ren Xiaoli , Wang Shuo , Liu Ruidong , Shi Bin , Dong Hailong , Wu Qingxia 
Published: February 2024

IntroductionThe etiology of Escherichia coli in yaks, along with its drug resistance, results in economic losses within the yak breeding industry. The utilization of lactic acid bacteria treatment has emerged as a viable alternative to antibiotics in managing colibacillosis.MethodsTo elucidate the therapeutic mechanisms of Lactobacillus against Escherichia coli-induced intestinal barrier damage in yaks, we employed yak epithelial cells as the experimental model and established a monolayer epithelial barrier using Transwell. The study encompassed four groups: a control group, a model group (exposed to E. coli O78), a low-dose Lactobacillus group (E. coli O78 + 1 × 105CFU LAB), and a high-dose Lactobacillus group (E. coli O78 + 1 × 107CFU LAB). Various techniques, including transmembrane resistance measurement, CFU counting, RT-qPCR, and Western Blot, were employed to assess indicators related to cell barrier permeability and tight junction integrity.ResultsIn the Model group, Escherichia coli O78 significantly compromised the permeability and tight junction integrity of the yak epithelial barrier. It resulted in decreased transmembrane resistance, elevated FD4 flux, and bacterial translocation. Furthermore, it downregulated the mRNA and protein expression of MUC2, Occludin, and ZO-1, while upregulating the mRNA expression and protein expression of FABP2 and Zonulin, thereby impairing intestinal barrier function. Contrastingly, Lactobacillus exhibited a remarkable protective effect. It substantially increased transmembrane resistance, mitigated FD4 flux, and reduced bacterial translocation. Moreover, it significantly upregulated the mRNA and protein expression of MUC2, Occludin, and ZO-1, while downregulating the mRNA and protein expression of FABP2 and Zonulin. Notably, high-dose LAB demonstrated superior regulatory effects compared to the low-dose LAB group.DiscussionIn conclusion, our findings suggest that Lactobacillus holds promise in treating yak colibacillosis by enhancing mucin and tight junction protein expression. Furthermore, we propose that Lactobacillus achieves these effects through the regulation of Zonulin.
Case Report: Complete atrioventricular block in an elderly patient with acute pulmonary embolism
Authors: Kim Moojun , Seo Chang-ok , Kim Hangyul , Kim Hye Ree , Kim Kyehwan , Kang Min Gyu , Park Jeong Rang 
Published: February 2024

IntroductionMultiple abnormal electrocardiographic findings have been documented in patients experiencing acute pulmonary embolism. Although sinus tachycardia is the most commonly encountered rhythmic disturbance, subsequent reports have highlighted other findings. These include right bundle branch block, right axis deviation, nonspecific ST segment/T wave changes, and T wave inversion in the right precordial leads. To date, only a limited number of cases involving a complete atrioventricular block have been reported in acute pulmonary embolism.Case presentationHere, we present the case of a 91-year-old woman with acute pulmonary embolism, whose initial electrocardiogram showed a complete atrioventricular block. She presented with presyncope and an initial blood pressure of 77/63 mmHg. Echocardiography confirmed signs of right ventricular dysfunction. Catheter-directed thrombolysis and a temporary pacemaker insertion were carried out sequentially. The following day, electrocardiography showed sinus rhythm with a left bundle branch block.DiscussionThe presence of a complete atrioventricular block in patients with acute pulmonary embolism serves as a clinical marker of high-risk status.
An environmental flow to an ephemeral creek increases the input of carbon and nutrients to a downstream receiving river
Authors: Liu Xiaoying , Watts Robyn J. , Dyer James 
Published: February 2024

Although intermittent and ephemeral rivers lack surface flow for part of the year, they provide vital refuges for biota in otherwise dry semi-arid and arid landscapes. The hydrology of many such rivers has been altered due to river regulation and climate change. Environmental flows can be delivered to address the negative impacts of regulated flows, however there is limited knowledge of how dry ephemeral ecosystems respond following environmental flows. This study examined changes in water quality of the ephemeral Thule Creek in the southern Murray-Darling Basin, Australia, following delivery of environmental water from an irrigation canal. We also examined how the environmental flow influenced water quality of Wakool River that receives inflows from Thule Creek. Six sites in Thule Creek, three in Wakool River, and one in Yarraman irrigation channel (source water) were monitored for dissolved organic carbon (DOC), nutrients and dissolved oxygen (DO) once per week over 15 weeks from October 2019 to January 2020. The environmental flow resulted in high DOC concentrations (4.4–76 mg/L). Although low DO levels at sites in Thule Creek were recorded on some dates below the threshold for fish stress (&lt; 4 mg/L) there were no fish kills observed during the environmental flow. The carbon-rich and nutrient-rich water (DOC &gt;10 mg/L, total phosphorus up to 94 μg/L, total nitrogen up to 1,125 μg/L) was detected in the Wakool River downstream of Thule Creek confluence compared to the Wakool River upstream of Thule Creek confluence (DOC 6.6 mg/L, total phosphorus up to 64 μg/L, total nitrogen up to 805 μg/L) during the period when the environmental flow in Thule Creek was connected with the Wakool River. This research provides an example of how irrigation canal networks can be used to deliver environmental water to an ephemeral river to maintain refuges and contribute to the productivity of a receiving river further downstream. Careful management of the timing, volume and duration of environmental flows in arid or semi-arid landscapes is needed to avoid the development of poor water quality during, or following, the delivery of environmental water.
Brain reward function in people who use cannabis: a systematic review
Authors: Beyer Emillie , Poudel Govinda , Antonopoulos Stephanie , Thomson Hannah , Lorenzetti Valentina 
Published: February 2024

RationaleCannabis is one of the most widely used psychoactive substances globally. Cannabis use can be associated with alterations of reward processing, including affective flattening, apathy, anhedonia, and lower sensitivity to natural rewards in conjunction with higher sensitivity to cannabis-related rewards. Such alterations have been posited to be driven by changes in underlying brain reward pathways, as per prominent neuroscientific theories of addiction. Functional neuroimaging (fMRI) studies have examined brain reward function in cannabis users via the monetary incentive delay (MID) fMRI task; however, this evidence is yet to be systematically synthesised.ObjectivesWe aimed to systematically integrate the evidence on brain reward function in cannabis users examined by the MID fMRI task; and in relation to metrics of cannabis exposure (e.g., dosage, frequency) and other behavioural variables.MethodWe pre-registered the review in PROSPERO and reported it using PRISMA guidelines. Literature searches were conducted in PsycINFO, PubMed, Medline, CINAHL, and Scopus.ResultsNine studies were included, comprising 534 people with mean ages 16-to-28 years, of which 255 were people who use cannabis daily or almost daily, and 279 were controls. The fMRI literature to date led to largely non-significant group differences. A few studies reported group differences in the ventral striatum while participants anticipated rewards and losses; and in the caudate while participants received neutral outcomes. A few studies examined correlations between brain function and withdrawal, dosage, and age of onset; and reported inconsistent findings.ConclusionsThere is emerging but inconsistent evidence of altered brain reward function in cannabis users examined with the MID fMRI task. Future fMRI studies are required to confirm if the brain reward system is altered in vulnerable cannabis users who experience a Cannabis Use Disorder, as postulated by prominent neuroscientific theories of addiction.
The interplay of food-related lifestyle and eating behavior in Italian women
Authors: Hamam Manal , D’Amico Mario , Spina Daniela , La Via Giovanni , Di Vita Giuseppe 
Published: February 2024

IntroductionWomen play a crucial role in food shopping and preparation, and their food choices have significant implications for their health and that of their families. This study aims to provide a perspective on women’s eating lifestyle, which has undergone significant changes.MethodsA factor analysis was conducted to assess the degree of involvement in food choices and the types of food items consumed among a sample of 399 Italian women.ResultsThrough cluster analysis, four segments were identified: hedonic food consumers, sustainable- and balanced-diet consumers, food experimenters, and no food fondness consumers. The results reveal a correlation between the degree of food involvement and the type of food consumed.DiscussionFurthermore, the food lifestyle of the sample is partially dependent on age. Individuals aged 25–28 years show more hedonic food consumption behavior, while the older age group (44–64 years) falls into the sustainable and balanced diet consumer cluster (the largest cluster) and the cluster of those who do not express definable food choices (no food fondness).
Predicting the status of lymphovascular space invasion using quantitative parameters from synthetic MRI in cervical squamous cell carcinoma without lymphatic metastasis
Authors: Guo Limei , Zhang Runmei , Xu Yi , Wu Wenqi , Zheng Qian , Li Jianting , Wang Jun , Niu Jinliang 
Published: February 2024

PurposeTo investigate the value of quantitative longitudinal relaxation time (T1), transverse relaxation time (T2), and proton density (PD) maps derived from synthetic magnetic resonance imaging (MRI) for evaluating the status of lymphovascular space invasion (LVSI) in cervical squamous cell carcinoma (CSCC) without lymph node metastasis (LNM).Material and methodsPatients with suspected cervical cancer who visited our hospital from May 2020 to March 2023 were collected. All patients underwent preoperative MRI, including routine sequences and synthetic MRI. Patients with pathologically confirmed CSCC without lymphatic metastasis were included in this study. The subjects were divided into negative- and positive-LVSI groups based on the status of LVSI. Quantitative parameters of T1, T2, and PD values derived from synthetic MRI were compared between the two groups using independent samples t-test. Receiver operating characteristic curves were used to determine the diagnostic efficacy of the parameters.Results59 patients were enrolled in this study and were classified as positive (n = 32) and negative LVSI groups (n = 27). T1 and T2 values showed significant differences in differentiating negative-LVSI from positive-LVSI CSCC (1307.39 ± 122.02 vs. 1193.03 ± 107.86, P&lt;0.0001; 88.42 ± 7.24 vs. 80.99 ± 5.50, P&lt;0.0001, respectively). The area under the curve (AUC) for T1, T2 values and a combination of T1 and T2 values were 0.756, 0.799, 0.834 respectively, and there is no statistically significant difference in the diagnostic efficacy between individual and combined diagnosis of each parameter.ConclusionsQuantitative parameters derived from synthetic MRI can be used to evaluate the LVSI status in patients with CSCC without LNM.
Case Report: The acute appendicitis and incarcerated umbilical hernia: a rare association
Authors: Corbi Letizia , Frediani Simone , Aloi Ivan Pietro , Bertocchini Arianna , Accinni Antonella , Pardi Valerio , Inserra Alessandro 
Published: February 2024

IntroductionOne of the most prevalent congenital wall abnormalities in children, umbilical hernias are often linked to premature or small-for-gestational-age babies. In cases of intestinal malrotation or if the cecum is very movable, generalized peritonitis may facilitate the imprisonment of these hernias.Case reportWe described a case of a 4-month-old baby who had a prior reducible umbilical hernia with a history of fever, vomiting, poor appetite, and constipation for around 48 h. The patient experienced significant intestinal bloating, vomiting, irreducibility of the umbilical hernia, skin pigmentation, and erythema at the umbilical site within 2 days after hospitalization. When there was no free abdominal air, a direct abdominal x-ray revealed evidence of hydro-gas stasis and various hydro-aerial levels that were pertinent to the ileum. In order to reduce the hernia, the patient had an emergency surgical treatment where the hernia sac was isolated and released from the ileal loop, which was securely attached to a fibrin plate. When the herniary sac was opened, a gangrenous and perforated appendix was found inside. On the seventh postoperative day, the patient was released from the hospital after an uncomplicated postoperative stay.ConclusionOur patient's clinical presentation is similar to that of only one other case report involving a 25-day-old male patient. Our case presented with a variant of the clinical symptoms of the previously described umbilical hernia, which became unfixable and strangulated as a result of appendix inflammation. The appendix was discovered inside the hernia sac during surgery.
Optimization of soybean physiochemical, agronomic, and genetic responses under varying regimes of day and night temperatures
Authors: Ding Chuanbo , Alghabari Fahad , Rauf Muhammad , Zhao Ting , Javed Muhammad Matloob , Alshamrani Rahma , Ghazy Abdel-Halim , Al-Doss Abdullah A. , Khalid Taimoor , Yang Seung Hwan , Shah Zahid Hussain 
Published: February 2024

Soybean is an important oilseed crop worldwide; however, it has a high sensitivity to temperature variation, particularly at the vegetative stage to the pod-filling stage. Temperature change affects physiochemical and genetic traits regulating the soybean agronomic yield. In this regard, the current study aimed to comparatively evaluate the effects of varying regimes of day and night temperatures (T1 = 20°C/12°C, T2 = 25°C/17°C, T3 = 30°C/22°C, T4 = 35°C/27°C, and T5 = 40°C/32°C) on physiological (chlorophyll, photosynthesis, stomatal conductance, transpiration, and membrane damage) biochemical (proline and antioxidant enzymes), genetic (GmDNJ1, GmDREB1G;1, GmHSF-34, GmPYL21, GmPIF4b, GmPIP1;6, GmGBP1, GmHsp90A2, GmTIP2;6, and GmEF8), and agronomic traits (pods per plant, seeds per plant, pod weight per plant, and seed yield per plant) of soybean cultivars (Swat-84 and NARC-1). The experiment was performed in soil plant atmosphere research (SPAR) units using two factorial arrangements with cultivars as one factor and temperature treatments as another factor. A significant increase in physiological, biochemical, and agronomic traits with increased gene expression was observed in both soybean cultivars at T4 (35°C/27°C) as compared to below and above regimes of temperatures. Additionally, it was established by correlation, principal component analysis (PCA), and heatmap analysis that the nature of soybean cultivars and the type of temperature treatments have a significant impact on the paired association of agronomic and biochemical traits, which in turn affects agronomic productivity. Furthermore, at corresponding temperature regimes, the expression of the genes matched the expression of physiochemical traits. The current study has demonstrated through extensive physiochemical, genetic, and biochemical analyses that the ideal day and night temperature for soybeans is T4 (35°C/27°C), with a small variation having a significant impact on productivity from the vegetative stage to the grain-filling stage.