bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gesundheitsbezogene Versorgungsforschung im Kindes- und Jugendalter
Authors: De Bock Freia , Borusiak Peter , Inhestern Laura , Thyen Ute 
Published: November 2023

Zusammenfassung
Hintergrund
Die Versorgungsforschung (VF) für die Zielgruppe Kinder und Jugendliche ist ein junges, sich aber dynamisch entwickelndes Forschungsfeld in Deutschland. Versorgungsforschung hat eine hohe Relevanz für eine rationale, qualitativ hochwertige und gerechte Gesundheitsversorgung.

Ziel der Arbeit
In dieser Übersicht werden spezifische inhaltliche und methodische Anforderungen an die VF im Kindes- und Jugendalter beschrieben. Anhand von Kindern und Jugendlichen mit besonderem (sozialpädiatrischem) Versorgungsbedarf werden die Komplexität der Versorgungsprozesse und -strukturen sowie mögliche Ansätze für bedarfs- und zukunftsgerichtete Versorgungsmodelle aufgezeigt.

Material und Methoden
Neben einer Literaturrecherche werden spezifische Informationen aus der Fachgruppe (FG) Kinder und Jugendliche im Deutschen Netzwerk Versorgungsforschung (DNVF) und Daten aus einem sozialpädiatrischen Verbundprojekt genutzt.

Ergebnisse und Diskussion
Für die VF im Kindes- und Jugendalter bestehen im Vergleich zu VF bei Erwachsenen Herausforderungen, die v. a. mit der fortdauernden Entwicklung im Kindesalter, dem Eingebettetsein in die Familie, der großen Bedeutung von alltäglichen Lebenswelten sowie der Zuständigkeit von Akteuren unterschiedlicher Disziplinen und Systeme verbunden ist. Die VF kann wichtige Beiträge zu einer rationalen Gesundheitspolitik für Kinder und Jugendliche liefern und sollte vermehrt auch von Kinderärzt:innen als alternatives Forschungsfeld bearbeitet werden. Förderpolitiken sollten Nachhaltigkeit, langfristige Beobachtungszeiten und Beteiligung der Zielgruppe an der Ausgestaltung von Förderlinien besonders berücksichtigen.
MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway
Authors: Liao Wenyan , Deng Xin , Chen Guodong , Yang Juanli , Li Yi , Li Li , Zhong Lili , Tao Guangwei , Hou Jiafeng , Li Mujun , Ding Chengming 
Published: November 2023

Abstract
Purpose
The purpose of this study is to investigate the function of miR-150-5p in URSA.

Method
Twenty-six chorionic villous tissues were collected to examine the expression of miR-150-5p and VEGFA by using quantitative polymerase chain reaction (qPCR) and western blot assay, respectively. Transwell assay was conducted to assess the migration and invasion ability of trophoblast cells. The dual-luciferase reporter assay was applied to determine the relationship between miR-150-5p and VEGFA in vitro. Relevant signaling pathway protein expression level was measured via western blot assay. Signaling transduction inhibitor LY294002 was used to block PI3K/AKT/mTOR signaling pathway. Finally, in vivo the effect of miR-150-5p on embryonic absorption rate was evaluated in mice.

Results
Clinical samples revealed that miR-150-5p expression was significantly elevated in the villous tissues and serum of URSA patients. Moreover, the overexpressing of miR-150-5p could inhibit both HTR-8/SVneo cell and JAR cell migration, invasion, and restrained PI3K/AKT/mTOR signaling pathway by targeting VEGFA in vitro. This inhibitory effect of miR-150-5p could be reversed by overexpressing the gene of vascular epithelial growth factor A (VEGFA). In contrary, inhibition of miR-150-5p significantly enhanced migration, invasion ability of both HTR-8/SVneo and JAR cells, and also could stimulate PI3K/AKT/mTOR signaling pathway. This promoting effect of miR-150-5p could be ameliorated by LY294002 (PI3K inhibitor). Finally, after miR-150-5p overexpression in vivo, the embryo resorption rate in pregnant mice was increased significantly.

Conclusions
Overall, these findings imply that miR-150-5p is among the key factors that regulate the pathogenesis of URSA.
Consensus on criteria for acromegaly diagnosis and remission
Authors: Giustina Andrea , Biermasz Nienke , Casanueva Felipe F. , Fleseriu Maria , Mortini Pietro , Strasburger Christian , van der Lely A. J. , Wass John , Melmed Shlomo ,   Acromegaly Consensus Group, Banfi Giuseppe , Barkan Ariel , Beckers Albert , Bidlingmaier Martin , Boguszewski Cesar , Brue Thierry , Buchfelder Michael , Chanson Philippe , Chiloiro Sabrina , Colao Annamaria , Coopmans Eva , Esposito Daniela , Ferone Diego , Frara Stefano , Gadelha Mônica , Geer Eliza B. , Ghigo Ezio , Greenman Yona , Gurnell Mark , Ho Ken , Ioachimescu Adriana , Johannsson Gudmundur , Jørgensen Jens Otto , Kaiser Ursula B. , Karavitaki Niki , Katznelson Laurence , Lamberts Stephen , Losa Marco , Luger Anton , Luque Raúl , Maffei Pietro , Marazuela Mónica , Neggers Sebastian , Pereira Alberto , Persani Luca , Petersenn Stephan , Reincke Martin , Salvatori Roberto , Samson Susan N. , Schilbach Katharina , Shimon Ilan , Tsagarakis Stylianos , Zatelli Maria Chiara 
Published: November 2023

Abstract
Purpose
The 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy.

Methods
Fifty-six acromegaly experts from 16 countries reviewed and discussed current evidence focused on biochemical assays; criteria for diagnosis and the role of imaging, pathology, and clinical assessments; consequences of diagnostic delay; criteria for remission and recommendations for follow up; and the value of assessment and monitoring in defining disease progression, selecting appropriate treatments, and maximizing patient outcomes.

Results
In a patient with typical acromegaly features, insulin-like growth factor (IGF)-I > 1.3 times the upper limit of normal for age confirms the diagnosis. Random growth hormone (GH) measured after overnight fasting may be useful for informing prognosis, but is not required for diagnosis. For patients with equivocal results, IGF-I measurements using the same validated assay can be repeated, and oral glucose tolerance testing might also be useful. Although biochemical remission is the primary assessment of treatment outcome, biochemical findings should be interpreted within the clinical context of acromegaly. Follow up assessments should consider biochemical evaluation of treatment effectiveness, imaging studies evaluating residual/recurrent adenoma mass, and clinical signs and symptoms of acromegaly, its complications, and comorbidities. Referral to a multidisciplinary pituitary center should be considered for patients with equivocal biochemical, pathology, or imaging findings at diagnosis, and for patients insufficiently responsive to standard treatment approaches.

Conclusion
Consensus recommendations highlight new understandings of disordered GH and IGF-I in patients with acromegaly and the importance of expert management for this rare disease.
Extreme Solar Events: Setting up a Paradigm
Authors: Usoskin Ilya , Miyake Fusa , Baroni Melanie , Brehm Nicolas , Dalla Silvia , Hayakawa Hisashi , Hudson Hugh , Jull A. J. Timothy , Knipp Delores , Koldobskiy Sergey , Maehara Hiroyuki , Mekhaldi Florian , Notsu Yuta , Poluianov Stepan , Rozanov Eugene , Shapiro Alexander , Spiegl Tobias , Sukhodolov Timofei , Uusitalo Joonas , Wacker Lukas 
Published: November 2023

AbstractThe Sun is magnetically active and often produces eruptive events on different energetic and temporal scales. Until recently, the upper limit of such events was unknown and believed to be roughly represented by direct instrumental observations. However, two types of extreme events were discovered recently: extreme solar energetic particle events on the multi-millennial time scale and super-flares on sun-like stars. Both discoveries imply that the Sun might rarely produce events, called extreme solar events (ESE), whose energy could be orders of magnitude greater than anything we have observed during recent decades. During the years following these discoveries, great progress has been achieved in collecting observational evidence, uncovering new events, making statistical analyses, and developing theoretical modelling. The ESE paradigm lives and is being developed. On the other hand, many outstanding questions still remain open and new ones emerge. Here we present an overview of the current state of the art and the forming paradigm of ESE from different points of view: solar physics, stellar–solar projections, cosmogenic-isotope data, modelling, historical data, as well as terrestrial, technological and societal effects of ESEs. Special focus is paid to open questions and further developments. This review is based on the joint work of the International Space Science Institute (ISSI) team #510 (2020–2022).
HelioSwarm: A Multipoint, Multiscale Mission to Characterize Turbulence
Authors: Klein Kristopher G. , Spence Harlan , Alexandrova Olga , Argall Matthew , Arzamasskiy Lev , Bookbinder Jay , Broeren Theodore , Caprioli Damiano , Case Anthony , Chandran Benjamin , Chen Li-Jen , Dors Ivan , Eastwood Jonathan , Forsyth Colin , Galvin Antoinette , Genot Vincent , Halekas Jasper , Hesse Michael , Hine Butler , Horbury Tim , Jian Lan , Kasper Justin , Kretzschmar Matthieu , Kunz Matthew , Lavraud Benoit , Le Contel Olivier , Mallet Alfred , Maruca Bennett , Matthaeus William , Niehof Jonathan , O’Brien Helen , Owen Christopher , Retinò Alessandro , Reynolds Christopher , Roberts Owen , Schekochihin Alexander , Skoug Ruth , Smith Charles , Smith Sonya , Steinberg John , Stevens Michael , Szabo Adam , TenBarge Jason , Torbert Roy , Vasquez Bernard , Verscharen Daniel , Whittlesey Phyllis , Wickizer Brittany , Zank Gary , Zweibel Ellen 
Published: November 2023

AbstractHelioSwarm (HS) is a NASA Medium-Class Explorer mission of the Heliophysics Division designed to explore the dynamic three-dimensional mechanisms controlling the physics of plasma turbulence, a ubiquitous process occurring in the heliosphere and in plasmas throughout the universe. This will be accomplished by making simultaneous measurements at nine spacecraft with separations spanning magnetohydrodynamic and sub-ion spatial scales in a variety of near-Earth plasmas. In this paper, we describe the scientific background for the HS investigation, the mission goals and objectives, the observatory reference trajectory and instrumentation implementation before the start of Phase B. Through multipoint, multiscale measurements, HS promises to reveal how energy is transferred across scales and boundaries in plasmas throughout the universe.
Influence of Annealing Temperature on the Structural and Luminescence Features and Thermoluminescence Trap Parameters of Ca2Al2SiO7: Ce3+ Phosphors
Authors: Saraswathi A. Vidya , Naregundi Karunakara , Sayyed M. I. , Almousa Nouf. , Kamath Sudha D. 
Published: November 2023

AbstractCerium-doped Ca2Al2SiO7 phosphors were synthesized via the combustion technique and annealed at 1073 K, 1173 K, and 1373 K. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), photoluminescence (PL), and thermoluminescence (TL) studies were performed to explore the variation of structural, morphological, luminescence, and TL properties with annealing temperature. The XRD plot showed an increase in crystallinity with an increase in annealing temperature. Similarly, the enhancement of PL intensity with an increase in annealing temperature supports the increased crystallinity of the phosphor samples. Detailed analysis of traps and trap parameters was carried out using the principle of TL. Samples were irradiated with different γ-ray doses, and, on heating, luminescence was observed. Thus, TL glow curves were drawn and deconvoluted using computerized glow curve deconvolution (CGCD) and Chen’s peak shape method to study the traps and trap parameters. With increasing annealing temperature, an increase in TL intensity was observed. Regardless of annealing temperature, every sample displayed a linear dose–response for doses ranging from 3 Gy to 500 Gy. TL investigations suggested that the produced phosphors are suitable candidates for gamma dosimetry applications.
Functional Roles of CD133: More than Stemness Associated Factor Regulated by the Microenvironment
Authors: Moreno-Londoño Angela Patricia , Robles-Flores Martha 
Published: November 2023

AbstractCD133 protein has been one of the most used surface markers to select and identify cancer cells with stem-like features. However, its expression is not restricted to tumoral cells; it is also expressed in differentiated cells and stem/progenitor cells in various normal tissues. CD133 participates in several cellular processes, in part orchestrating signal transduction of essential pathways that frequently are dysregulated in cancer, such as PI3K/Akt signaling and the Wnt/β-catenin pathway. CD133 expression correlates with enhanced cell self-renewal, migration, invasion, and survival under stress conditions in cancer. Aside from the intrinsic cell mechanisms that regulate CD133 expression in each cellular type, extrinsic factors from the surrounding niche can also impact CD33 levels. The enhanced CD133 expression in cells can confer adaptive advantages by amplifying the activation of a specific signaling pathway in a context-dependent manner. In this review, we do not only describe the CD133 physiological functions known so far, but importantly, we analyze how the microenvironment changes impact the regulation of CD133 functions emphasizing its value as a marker of cell adaptability beyond a cancer-stem cell marker.
Graphical Abstract
Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
Authors: Bortolasci Chiara C , Jaehne Emily J , Hernández Damián , Spolding Briana , Connor Timothy , Panizzutti Bruna , Dean Olivia M , Crowley Tamsyn M , Yung Alison R , Gray Laura , Kim Jee Hyun , van den Buuse Maarten , Berk Michael , Walder Ken 
Published: November 2023

AbstractNovel approaches are required to find new treatments for schizophrenia and other neuropsychiatric disorders. This study utilised a combination of in vitro transcriptomics and in silico analysis with the BROAD Institute’s Connectivity Map to identify drugs that can be repurposed to treat psychiatric disorders. Human neuronal (NT2-N) cells were treated with a combination of atypical antipsychotic drugs commonly used to treat psychiatric disorders (such as schizophrenia, bipolar disorder, and major depressive disorder), and differential gene expression was analysed. Biological pathways with an increased gene expression included circadian rhythm and vascular endothelial growth factor signalling, while the adherens junction and cell cycle pathways were transcriptionally downregulated. The Connectivity Map (CMap) analysis screen highlighted drugs that affect global gene expression in a similar manner to these psychiatric disorder treatments, including several other antipsychotic drugs, confirming the utility of this approach. The CMap screen specifically identified metergoline, an ergot alkaloid currently used to treat seasonal affective disorder, as a drug of interest. In mice, metergoline dose-dependently reduced MK-801- or methamphetamine-induced locomotor hyperactivity confirming the potential of metergoline to treat positive symptoms of schizophrenia in an animal model. Metergoline had no effects on prepulse inhibition deficits induced by MK-801 or methamphetamine. Taken together, metergoline appears a promising drug for further studies to be repurposed as a treatment for schizophrenia and possibly other psychiatric disorders.
Molecular beam laser spectroscopic studies of the photoactive properties of resveratrol
Authors: Fan Jiayun , Buma Wybren Jan 
Published: November 2023

AbstractResonance Enhanced MultiPhoton Ionization spectroscopic techniques coupled with laser desorption and supersonic cooling have been employed to elucidate the photoactive properties of resveratrol. The observed excitation spectra give evidence for an internal-energy dependent trans–cis isomerisation pathway in the electronically excited state, while pump-probe studies show dynamics that are in line with what is known for the parent compound, trans-stilbene. Similar studies have been performed on a derivative of resveratrol with methoxy instead of hydroxy groups, a compound aimed to reduce previously observed photodegradation pathways of resveratrol. Time-resolved studies of the latter compound under solution conditions have given further insight into its excited-state dynamics and support the isolated-molecule conclusions on the topology of the potential energy surface of the electronically excited state. Spectroscopic studies under prolonged irradiation conditions show that both compounds suffer from photodegradation, although in the alkylated compound other pathways appear to be involved than in resveratrol.
Graphical abstract
Embedding data science innovations in organizations: a new workflow approach
Authors: Li Keyao , Griffin Mark A. , Barker Tamryn , Prickett Zane , Hodkiewicz Melinda R. , Kozman Jess , Chirgwin Peta 
Published: November 2023

Abstract
There have been consistent calls for more research on managing teams and embedding processes in data science innovations. Widely used frameworks (e.g., the cross-industry standard process for data mining) provide a standardized approach to data science but are limited in features such as role clarity, skills, and cross-team collaboration that are essential for developing organizational capabilities in data science. In this study, we introduce a data workflow method (DWM) as a new approach to break organizational silos and create a multi-disciplinary team to develop, implement and embed data science. Different from current data science process workflows, the DWM is managed at the system level that shapes business operating model for continuous improvement, rather than as a function of a particular project, one single business unit, or isolated individuals. To further operationalize the DWM approach, we investigated an embedded data workflow at a mining operation that has been using geological data in a machine-learning model to stabilize daily mill production for the last 2 years. Based on the findings in this study, we propose that the DWM approach derives its capability from three aspects: (a) a systemic data workflow; (b) multi-disciplinary networks of collaboration and responsibility; and (c) clearly identified data roles and the associated skills and expertise. This study suggests a whole-of-organization approach and pathway to develop data science capability.
Global Participatory Democracy through a UN World Citizens’ Initiative? Mapping the Theoretical and Institutional Terrain
Authors: Murphy Ben L. , Organ James 
Published: November 2023

AbstractThe burgeoning literature on the democratic deficit of international organizations, and the United Nations in particular, has, for the most part, inherited a pervasive state-centrism commonly associated with conventional approaches to international law more generally. While this approach is understandable, it appears incompatible with a holistic account of democracy, especially accounts that seek to situate the locus of power within the individual. Drawing on attempts to empower individual citizens to influence global governance decision-making in other contexts—especially the experience of the European Citizens’ Initiative—this Article considers a bold idea: The establishment of a “World Citizens’ Initiative,” through which individuals could directly influence the agenda of the primary organs of the United Nations. This Article critically analyzes the legal feasibility of such an initiative and the challenges of implementation. In doing so, it offers both a theoretical and institutional contribution to the debate about the normative case for the democratization of global governance through effective citizen participation.
Imperial Presidency Versus Fragmented Executive? Unilateral Trade Measures and Executive Accountability in the European Union and the United States
Authors: Verellen Thomas 
Published: November 2023

AbstractFaced with a changing geopolitical environment, the European Union has embarked on a legislative program to upgrade its unilateral trade instruments toolbox. By reforming existing instruments—for example, anti-dumping—and by adding new instruments to the European Commission’s toolbox (foreign subsidies instrument, international procurement instrument, anti-coercion instrument, and others), the EU legislature is significantly strengthening the position of the Commission in the governance of unilateral trade policy in the EU. This development raises accountability questions. By means of a comparative analysis of democratic accountability in unilateral trade policy in the United States and the EU, I describe this transformation of executive power in the EU and I argue that a further strengthening of democratic accountability mechanisms is needed to match the Commission’s growing responsibilities in this underexamined corner of EU trade policy.
Dynamics of multilayer Rayleigh–Taylor instability at moderately high Atwood numbers
Authors: Suchandra Prasoon , Ranjan Devesh 
Published: November 2023

This paper investigates the multilayer Rayleigh–Taylor instability (RTI) using statistically stationary experiments conducted in a gas tunnel. Employing diagnostics such as particle image velocimetry (PIV) and planar laser induced fluorescence (PLIF), we make simultaneous velocity–density measurements to study how dynamics and mixing are linked in this variable density flow. Experiments are conducted in a newly built, blow-down three-layer gas tunnel facility. Mixing between three gas streams is studied, where the top and bottom streams are comprised of air, and the middle stream is an air–helium mixture. Shear is minimized between these streams by matching their inlet velocities. The four experimental conditions investigated here consist of two different density ratios (Atwood numbers 0.3 and 0.6), each investigated at two instability development times (or equivalently, two streamwise locations), and all experiments are with the same middle stream thickness of 3 cm. The growth of the middle layer is measured using laser-based planar Mie scattering visualization. The mixing width is found to grow linearly with time at late times. Various quantitative measures of molecular mixing indicate a very high degree of molecular mixing at late times in the multilayer RTI flow. The vertical turbulent mass flux$a_y$is calculated. In addition to mostly negative values of$a_y$, typical of buoyancy-dominated flows due to negative correlation between velocity and density fluctuations, positive regions are also observed in profiles of$a_y$due to entrainment and erosion at the lower edge of the mixing region. Global energy budgets are calculated for the multilayer RTI flow at late times and it is found that the majority of potential energy released has been dissipated due to viscous effects, and a large value of mixing efficiency ($\sim$60 %) is observed.