bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Effects of a Single Bout of Strength and Endurance Exercise on Vitamin D Metabolites in Young Adults
Authors: Mosti Mats Peder , Aagård Norun , Stunes Astrid Kamilla , Brobakken Cathrine Langlie , Brevig Martin Siksjø , Gustafsson Miriam K. , Thorsby Per Medbøe , Wang Eivind , Syversen Unni 
Published: January 2025

ABSTRACT

Purpose
The effect of exercise on serum concentration of vitamin D metabolites remains inconclusive, with studies reporting deviating results. This study evaluated the acute effect of a single session of two specific exercise forms; strength training (ST) and high-intensity interval training (HIIT), on circulating 25-hydroxyvitamin D (25(OH)D), free25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D), and skeletal muscle vitamin D receptor (VDR) gene expression, in healthy adults.

Methods
Thirty-nine participants (19 women and 20 men, age 21–30 years) completed a single bout of ST and HIIT exercise, separated by two weeks. Serum concentration of total 25(OH)D, free25(OH)D and 1,25(OH)2D were assessed before exercise, immediately after, and 3 hours and 24 hours after each session. Muscle biopsies were obtained at rest (1st visit), and at 3 hours and 24 hours post ST and HIIT, and analyzed for VDR gene expression. Repeated measures ANOVA was used to assess serum concentration across time, while paired samples t-test was used for muscle VDR gene expression analyses.

Results
Serum concentration of 25(OH)D or free 25(OH)D did not change after either exercise mode when correcting for plasma volume alterations. 1,25(OH)2D was reduced by 13.1 ± 18.3 pmol/L and 7.1 ± 9.6 pmol/L immediately after ST and HIIT, respectively (P < 0.001). Muscle VDR mRNA expression increased after ST by 3.1 ± 1.8 (3 hr) and 2.2 ± 1.7 (24 hr) fold change (P < 0.05).

Conclusions
One single session of ST or HIIT did not alter serum concentration of 25(OH)D and free 25(OH)D when correcting for plasma volume changes. Both exercise modes caused a transient reduction in 1,25(OH)2D suggesting utilization of 1,25(OH)2D by muscle cells following exercise. Elevated VDR gene expression following ST suggests a functional role of VDR in fast-twitch muscle fibers.
Emergency primary anastomosis with or without intraoperative colonic lavage following sigmoidectomy in sigmoid volvulus: 175-patient experience in a tertiary referral hospital
Authors: Altundas Necip , Peksoz Rifat , Disci Esra , Atamanalp Sabri Selcuk 
Published: January 2025

Objectives: Emergency primary anastomosis following sigmoidectomy is one of the main treatment options in sigmoid volvulus (SV). However, during this procedure, the role of intraoperative colonic lavage (ICL) is controversial. Our aim was to evaluate the role of ICL in 175-patient SV series.
Methods: In Ataturk University Faculty of Medicine Department of General Surgery, ICL was applied in 76 cases (43.4%), while it was not used in the remained 99 patients (56.6%) in 58.5-year period. In a partial retrospective (first 20 years, from June 1966 to June 1986) and prospective (later 38.5 years, from June 1986 to December 2024) evaluation, some preoperative, operative, and postoperative findings were utilized.
Results: As preoperative data, mean age (56.4 years vs. 57.1 years, P>0.05), male/female ratio (4.8 vs. 4.2, P>0.05), and rate of shock (5.3% vs. 6.1%, P>0.05) were statistically similar in both groups, while mean ASA score (3.1 vs. 2.9, P<0.05) was significantly lower in ICL group. Among operative findings, rates of bowel gangrene (67.1% vs. 63.6%, P>0.05) and perforation (1.3% vs. 1.0%, P>0.05) were statistically similar in both groups, while mean operation time (205.4 minutes vs. 176.8 minutes, P<0.005) was significantly longer in ICL group. As surgical outcomes, rates of mortality (13.2% vs 12.1%, P>0.05) and morbidity (39.5% vs. 28.3%, P>0.05) were statistically similar in both groups, while mean hospitalization time (14.7 days vs. 9.4 days, P<0.001) was significantly longer and mean cost (3,455.4 USD vs. 2,752.1 USD, P<0.001) was significantly higher in ICL group.
Conclusion: When compared with that of primary anastomosis with ICL, primary anastomosis without ICL provided shorter operation and hospitalization times, and less cost in addition to similar mortality and morbidity rates in the emergency treatment of SV.
doi: https://doi.org/10.12669/pjms.41.2.11399
How to cite this: Altundas N, Peksoz R, Disci E, Atamanalp SS. Emergency primary anastomosis with or without intraoperative colonic lavage following sigmoidectomy in sigmoid volvulus: 175-patient experience in a tertiary referral hospital. Pak J Med Sci. 2025;41(2):603-607. doi: https://doi.org/10.12669/pjms.41.2.11399
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Evaluating Efficacy and Safety of Crisaborole in Managing Childhood Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis
Authors: You Jianhua , Li Huanmei , Wang Zhongyun , Zhao Yunfei 
Published: January 2025

Aims/Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder globally. Crisaborole, a nonsteroidal topical phosphodiesterase 4 inhibitor (PDE4i), has been utilized in treating AD. Crisaborole regulates the production of inflammatory cytokines, which are usually overactive among AD patients. Therefore, this study aimed to explore the efficacy and safety of crisaborole in treating AD in patients aged ≤18 years. Methods A literature search was performed across PubMed, MEDLINE, Embase, Cochrane, and Google Scholar. The inclusion criteria involved primary studies evaluating the effect of crisaborole in treating dermatitis, articles exploring the use of crisaborole in AD patients below 18 years (>two years), and articles published in English between 2000 and 2022. However, the studies evaluating AD in adult patients, those reporting treatments other than crisaborole, those published before 2000, and articles written in languages other than English were excluded from this analysis. Furthermore, secondary data sources such as case reports, newspaper articles, magazines, and other systematic reviews and meta-analyses were excluded. A meta-analysis was conducted using RevMan 5.4. The risk of bias in the manuscripts was assessed using the Cochrane tool. The I-square test statistic was used to determine heterogeneity, and Egger’s test was used to evaluate publication bias. Results Ten studies met the eligibility criteria and were included in the final analysis. Most of the studies exhibited a low risk of bias with no publication bias. Meta-analysis indicated a significant difference in the number of patients attaining Investigator Static Global Assessment (ISGA) success at day 29, with significantly higher patients in the crisaborole group than in the vehicle group (odds ratio (OR) 1.56, 95% CI 1.24 to 1.96; I2 = 77%; p = 0.0001). Similarly, pruritus improvement was significant between the two cohorts at day 29, indicating significantly higher heterogeneity (OR 1.70, 95% CI 1.10 to 2.63; I2 = 91%; p = 0.02). Furthermore, the safety profiling of the treatments was insignificant, demonstrating no statistical difference in the treatment-emergent adverse events (TEAEs) between the two groups with high heterogeneity (OR 0.53, 95% CI 0.14 to 1.98; I2 = 99%; p = 0.35). Conclusion Crisaborole demonstrates substantial efficacy in treating mild to moderate AD compared to vehicle therapies, as it reduces the signs and symptoms of the disease. Furthermore, crisaborole is well tolerated and has an acceptable safety profile in treating mild to moderate AD patients.
Prediction of implant failure risk due to periprosthetic femoral fracture after primary elective total hip arthroplasty
Authors: Abdulhadi Alagha M. , Cobb Justin , Liddle Alexander D. , Malchau Henrik , Rolfson Ola , Mohaddes Maziar 
Published: January 2025

AimsWhile cementless fixation offers potential advantages over cemented fixation, such as a shorter operating time, concerns linger over its higher cost and increased risk of periprosthetic fractures. If the risk of fracture can be forecasted, it would aid the shared decision-making process related to cementless stems. Our study aimed to develop and validate predictive models of periprosthetic femoral fracture (PPFF) necessitating revision and reoperation after elective total hip arthroplasty (THA).MethodsWe included 154,519 primary elective THAs from the Swedish Arthroplasty Register (SAR), encompassing 21 patient-, surgical-, and implant-specific features, for model derivation and validation in predicting 30-day, 60-day, 90-day, and one-year revision and reoperation due to PPFF. Model performance was tested using the area under the curve (AUC), and feature importance was identified in the best-performing algorithm.ResultsThe Lasso regression excelled in predicting 30-day revisions (area under the receiver operating characteristic curve (AUC) = 0.85), while the Gradient Boosting Machine (GBM) model outperformed other models by a slight margin for all remaining endpoints (AUC range: 0.79 to 0.86). Predictive factors for revision and reoperation were identified, with patient features such as increasing age, higher American Society of Anesthesiologists grade (> III), and World Health Organization obesity classes II to III associated with elevated risks. A preoperative diagnosis of idiopathic necrosis increased revision risk. Concerning implant design, factors such as cementless femoral fixation, reverse-hybrid fixation, hip resurfacing, and small (< 35 mm) or large (> 52 mm) femoral heads increased both revision and reoperation risks.ConclusionThis is the first study to develop machine-learning models to forecast the risk of PPFF necessitating secondary surgery. Future studies are required to externally validate our algorithm and assess its applicability in clinical practice.Cite this article: Bone Joint Res 2025;14(1):46–57.
Factors associated with Catastrophic Healthcare Expenditure in communities of Lagos Nigeria: A Megacity experience
Authors: Wright Kikelomo Ololade , Adeniran Adeyinka , Aderibigbe Adedayo , Akinyemi Olufunsho , Fagbemi Temiloluwa , Ayodeji Omoyeni , Adepase Biola , Zamba Emmanuella , Abdurrazzaq Hussein , Oniyire Faith , Ogboye Olusegun , Abayomi Akin 
Published: January 2025

Background
Each year, millions of people in low—and middle-income countries such as Nigeria are forced into poverty and financial ruin due to out-of-pocket (OOP) healthcare expenses. Our study assessed the prevalence and determinants of Catastrophic Healthcare Expenditure (CHE) experienced by households in Lagos, Nigeria.

Methods
A descriptive community-based cross-sectional survey was conducted on 2492 households in Lagos from December 2022 to March 2023 in 4 Local Government Areas (LGAs) using a multistage sampling technique. Data was collected using pre-tested semi-structured questionnaires, and analysis was performed using STATA 15.0 software. Univariate, bivariate, and binary logistic regression analyses were conducted with statistical significance set at p<0.05, and a 95% Confidence Interval was calculated for the adjusted odds ratio (OR).

Results
The study revealed that 15% of households experience catastrophic health expenditure (CHE). Gender, marital status, educational level, occupation, personal income, health perception, household location, and health insurance enrollment were significantly associated with CHE. Additionally, gender, religion, income, household location, and self-rated health status were significant predictors of household CHE, with adjusted odds ratios of 4.42, 2.45, 1.00, 1.07, and 1.69, respectively.

Conclusion
CHE is more prevalent among people with lower socio-economic status, urban residents, and those lacking health insurance. It is crucial to implement targeted initiatives to raise awareness about the benefits of health insurance and simplify the enrollment process for vulnerable groups, thereby alleviating the financial strain of healthcare expenses.
The impact of The Quality and Safety Education (QSEN) program on the knowledge, skills, and attitudes of junior nurses
Authors: AlRatrout Salam , Abu Khader Imad , ALBashtawy Mohammed , Asia Mohammed , Alkhawaldeh Abdullah , Bani Hani Salam 
Published: January 2025

Background
The quality and safety education for nurses (QSEN) competency program represents a valuable initiative in nursing practice and education, equipping nurses with the essential knowledge, attitude, and skills (KAS) required to deliver safe, efficient, and patient-centered care.

Purpose
This study aims to determine the impact of QSEN competency on the KAS of nurses in Palestine.

Method
A quasi-experimental pre-test and post-test design with two groups was used utilizing a questionnaire to collect data from 164 Junior nurses in two governmental hospitals within the period of 25th, January to the 10th February 2024. Patricia Benner’s theory suggests that a strong educational foundation and diverse experiences enable nurses to enhance their patient care knowledge and abilities over time.

Results
The findings indicate that nurses in Palestine can benefit from targeted interventions and QSEN educational programs aimed at improving their patient-centered care competence, as post-test scores show a significant rise over pre-test scores. Junior nurses who participated in the QSEN program experienced a 57% increase in knowledge, a 57% increase in skills, and a 64% increase in attitudes. The intervention significantly improved knowledge (77.02 vs. 49.19, p < 0.001), quality and safety skills (70.16 vs. 44.61, p < 0.001), and attitudes (75.47 vs. 46.16, p < 0.001) among participants post-procedure, indicating a substantial positive impact on these areas, demonstrating the effectiveness of the educational intervention.

Conclusion
The study demonstrates that an educational intervention improves junior nurses’ KSAs for six QSEN competencies, leading to higher average scores in quality and safety competence subscales, thereby enhancing staff satisfaction, and reducing medical errors, and patient safety.
Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial
Authors: Muthukuda Dimuthu , de Silva Chamini Kanatiwela , Ajanthan Saumiyah , Wijesinghe Namal , Dahanayaka Anuradha , Pathmeswaran Arunasalam 
Published: January 2025

Background
Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately measure the lipid and glucose-lowering effects of Cinnamomum zeylanicum (C. zeylanicum) extract. This study primarily aimed to evaluate the effect of a standardized C. zeylanicum extract on serum low-density lipoprotein cholesterol (LDL-C) levels and secondarily on other lipid parameters (high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglycerides), glucose levels, anthropometric measures, blood pressure, and safety outcomes in individuals with an LDL level between 100-190mg/dL.

Materials and methods
This was a randomized, double-blinded, placebo-controlled clinical trial. Participants were allocated to either C. zeylanicum extract or placebo group (1:1 allocation ratio). They were advised to take two capsules per day (1000 mg/day, a dose based on prior clinical studies suggesting potential efficacy and safety). Reduction in LDL-C at 12 weeks (from the baseline value) was compared between the two groups using ANCOVA. A complete-case analysis was adhered to in analyzing the outcome data.

Results
The mean age (SD) of the 150 participants was 50.4 (10.52) years, and 66% were females. Among the 127 participants assessed at 12 weeks, those in the C. zeylanicum extract arm had a lower LDL-C value than the placebo arm but the difference was not significant (the baseline adjusted mean difference was 6.05mg/dL; 95% CI: -2.43 to 14.52; p = 0.161). However, participants in the C. zeylanicum extract group showed significantly greater reductions in fasting blood sugar (FBS) levels (the baseline adjusted mean difference was 8.59mg/dL; 95% CI: 0.59 to 16.59; p = 0.036). There was a significant interaction effect between the supplement and participants’ glycemic status, with individuals with type 2 diabetes mellitus (T2DM) who received C. zeylanicum extract experiencing a notable reduction in FBS levels (standardized coefficient: -63, 95% CI: -102 to -25; p = 0.002).

Conclusions
C. zeylanicum extract did not have significantly reduce LDL-C but demonstrated a significant FBS-lowering effect, particularly in individuals with T2DM, with a favorable safety profile.

Trials registration
The trial was registered with the Sri Lanka Clinical Trials Registry: SLCTR/2021/011.
Distinguishing benign and malignant myxoid soft tissue tumors: Performance of radiomics vs. radiologists
Authors: Lawrenz Joshua M. , Cui Can , Johnson Samuel R. , Hajdu Katherine S. , Chenard Stephen W. , Rekulapelli Akhil , Moran Cullen P. , Block John J. , Chadwick Nicholson S. , Shechtel Joanna L. , Bingham Brian , Luo Leo Y. , Halpern Jennifer L. , Schwartz Herbert S. , Holt Ginger E. , Smith David S. , Dawant Benoit , Kang Hakmook 
Published: January 2025

Introduction
Benign and malignant myxoid soft tissue tumors have shared clinical, imaging, and histologic features that can make diagnosis challenging. The purpose of this study is comparison of the diagnostic performance of a radiomic based machine learning (ML) model to musculoskeletal radiologists.

Methods
Manual segmentation of 90 myxoid soft tissue tumors (45 myxomas and 45 myxofibrosarcomas) was performed on axial T1, and T2FS or STIR magnetic resonance imaging sequences. Eighty-seven radiomic features from each modality were extracted. Five ML models were trained to classify tumors as benign or malignant in 40 tumors and then tested with an additional 50 tumors using cross validation. The accuracy of the best ML model based on area under the receiver operating characteristic curve (AUC) was compared to the consensus diagnosis of three musculoskeletal radiologists. Correlation between radiologist confidence (equivocal, probably, consistent with) and accuracy was tested.

Results
The best ML classifier was a logistic regression model (AUC 0.792). Using T1 + T2/STIR images, the ML model classified 78% (39/50) of tumors correctly at a similar rate compared to 74% (37/50) by radiologists. When radiologists disagreed, the consensus diagnosis classified 50% of tumors (7/14) correctly compared to 86% (12/14) by the ML model, though this did not reach statistical significance. Radiologists had a cumulative accuracy of 91% (30/33) when they rated their confidence ‘consistent with’ compared to 61% (31/51) when they rated their confidence ‘equivocal/probably’ (P = 0.006). For cases when radiologists rated their confidence ‘equivocal/probably’, the ML model had 76% accuracy (39/51).

Conclusions
A radiomic based ML model predicted benign or malignant diagnosis in myxoid soft tissue tumors similarly to the consensus diagnosis by three musculoskeletal radiologists. Radiologist confidence in the diagnosis strongly correlated with their diagnostic accuracy. Though radiomics and radiologists perform similarly overall, radiomics may provide novel diagnostic utility when radiologist confidence is low, or when radiologists disagree.
Playful Frames: Styles of Widescreen Cinema, Steven Rybin (2024)
Authors: Deutelbaum Marshall 
Published: January 2025

Review of: Playful Frames: Styles of Widescreen Cinema, Steven Rybin (2024)
New Brunswick, NJ: Rutgers University Press, 186 pp.,
ISBN 978-1-97881-595-7, h/bk, $150.00
ISBN 978-1-97881-594-0, p/bk, $42.95
Italian Political Cinema: Figures of the Long ’68, Mauro Resmini (2023)
Authors: Hegel Lorenz 
Published: January 2025

Review of: Italian Political Cinema: Figures of the Long ’68, Mauro Resmini (2023)
Minneapolis, MN and London: University of Minnesota Press, 302 pp.,
ISBN 978-1-51791-138-6, p/bk, $28.00
The Non-Professional Actor: Italian Neorealist Cinema and Beyond, Catherine O’Rawe (2024)
Authors: Leavitt Charles L. 
Published: January 2025

Review of: The Non-Professional Actor: Italian Neorealist Cinema and Beyond, Catherine O’Rawe (2024)
London: Bloomsbury Academic, 249 pp.,
ISBN 978-1-50139-435-5, h/bk, £90
Women’s Work in Post-War Italy: An Oral and Filmic History, Flora Derounian (2023)
Authors: Ramsey-Portolano Catherine 
Published: January 2025

Review of: Women’s Work in Post-War Italy: An Oral and Filmic History, Flora Derounian (2023)
Bristol: Intellect, xi+218 pp.,
ISBN 978-1-78938-812-1, h/bk, $134.95
Enhancing chemical security and safety in the education sector: a pilot study at the university of Zakho and Koya University as an initiative for Kurdistan’s Universities-Iraq
Authors: Saleh Dunya I. , Ahmed Kanaan R. , Ahmed Sangar S. , Tofiq Diary I. 
Published: January 2025

Abstract
Shortcomings in the chemical safety and security curriculum in Kurdistan universities and a lack of awareness have led to undesired incidents. Unassessed chemical risks in academic centers challenge compliance with health, safety, and environmental policies. To address this, a pilot study evaluated the effectiveness of a new chemical risk management curriculum. Results showed a 57.4 % increase in participants’ knowledge of chemical safety and security principles. Awareness of the distinction between safety and security improved significantly, from 18.8 % to 42.6 %. Interest in learning more about chemical safety rose from 35 % to 50 %. Statistical analysis summarized the findings, including weighted mean, ranked mean, grouped standard deviation, count, and percentages. The Wilcoxon Signed Rank Test assessed differences between pre- and post-surveys, with a p-value of 0.05 or less confirming statistical significance. This pilot study demonstrates the curriculum’s potential to enhance chemical safety and security knowledge, offering a model for other universities to reduce incidents and improve compliance with safety protocols.