bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astronomical influence on Miocene continental environments in Tibet, east-central Asia
Authors: Yao Xu , Dai Shuang , Wang Zhixiang , Li Mingsong , Hinnov Linda 
Published: January 2024

Abstract
Studies of Cenozoic lacustrine cyclostratigraphy in northeastern Tibet have been successful in reconstructing the history of precipitation and aridification at astronomical (Milankovitch) time scales. However, the phase relationships between Milankovitch forcing mechanisms and hydrologic changes are ambiguous because of challenges in interpreting climate proxies and dating continental successions. We present an analysis of Miocene red and green mudstone rhythmites in two basins (Jiuxi and Guide, NE Tibet) using a climate proxy based on lithologic color. Time-series analysis of the color proxy indicated a dominance of 405 k.y. cycles, from which we constructed an orbital eccentricity metronome astrochronology from 18 Ma to 10 Ma. Periods of lake expansion and contraction are characterized by the green and red mudstones, respectively, and correspond to orbital eccentricity minima and maxima, respectively. We interpreted the antiphase relationship between orbital eccentricity and hydrologic evolution using a net precipitation model, with low precipitation/evaporation ratio being due to excessively high evaporation during times of high orbital eccentricity, and vice versa. High orbital eccentricity scenarios with strong seasonality and insolation extremes are analogous to anthropogenic global warming, and our results provide insights into a future of Central Asian intensified aridification, following the “dry-gets-drier” global warming projections and regionally high aridity sensitivity.
Association between workplace social capital and systolic blood pressure among 23 173 workers at 367 small-sized and medium-sized enterprises in Japan: a cross-sectional study
Authors: Inoue Yosuke , Yazawa Aki , Muto Shigetaka , Odagiri Yuko , Miyake Haruka , Tobayama Mutsuko , Mizoue Tetsuya 
Published: January 2024

ObjectivesSocial capital (SC) has been shown to be inversely associated with elevated blood pressure. While SC in the workplace may also be associated with blood pressure, it has not been extensively studied. We aimed to investigate the association between workplace SC and systolic blood pressure (SBP).DesignA cross-sectional study.Setting367 small-sized and medium-sized companies in Japan.ParticipantsA total of 23 173 participants (15 991 males and 7182 females) aged ≥18 years.Exposure of interestSC was assessed using individual responses to eight 4-point Likert questions used in the Brief Job Stress Questionnaire. Workplace SC was assessed as the mean of individual-level responses to the SC questions from those working in the same company.Outcome measureSystolic blood pressure (SBP)ResultsA multilevel linear regression model revealed that higher workplace-level SC was linked with lower SBP (coef.=−0.53 per 1SD increment in workplace SC, 95% CI=−1.02 to −0.05) among females in the age-adjusted model, which remained statistically significant after adjusting for other covariates. After adjusting for individual-level SC, this association was attenuated and became non-significant (coef.=−0.41, 95% CI=−0.87 to 0.05), while individual-level SC was inversely associated with SBP (coef.=−0.43, 95% CI=−0.73 to −0.13). Among males, we did not find any evidence of significant inverse associations either in relation to workplace SC (coef.=−0.12, 95% CI=−0.46 to 0.21) or individual-level SC (coef.=0.19, 95% CI=−0.01 to 0.39).ConclusionsOur study findings suggested that workplace-level SC can affect SBP differently by sex.
Hemostatic effect of fibrinogen concentrate on traumatic massive hemorrhage: a propensity score matching study
Authors: Heo Yoonjung , Chang Sung Wook , Lee Seok Won , Ma Dae Sung , Kim Dong Hun 
Published: January 2024

BackgroundFibrinogen concentrate (FC) can be administered during massive transfusions to manage trauma-induced coagulopathy. However, its effectiveness in survival remains inconclusive due to scarce high-level evidence. This study aimed to investigate the hemostatic effects of FC regarding mortality in massive hemorrhage caused by trauma.MethodsThis retrospective study analyzed 839 patients who received massive transfusions (red blood cells (RBCs) ≥5 units in 4 hours or ≥10 units in 24 hours) at a level I trauma center between 2015 and 2022. Patients who were transferred to other hospitals or were deceased upon arrival, suffered or died from severe brain injury, and were aged 15 years or less were excluded (n=334). 1:2 propensity score matching was performed to compare the ‘FC (+)’ group who had received FC in 24 hours (n=68) with those who had not (‘FC (−)’, n=437). The primary outcome was mortality, and the secondary outcomes included transfusion volume.ResultsThe variables for matching included vital signs, injury characteristics, prehospital time, implementation of resuscitative endovascular balloon occlusion of the aorta, and blood gas analysis results. The administration of FC did not significantly reduce or predict mortality (in-hospital, 24 hours, 48 hours, or 7 days). The FC (−) group received more units of RBC (25.69 units vs. 16.71 units, p<0.001, standardized mean difference [SMD] 0.595), fresh frozen plasma (16.79 units vs. 12.91 units, p=0.023, SMD 0.321), and platelets (8.76 units vs. 5.46 units, p=0.002, SMD 0.446) than the FC (+) group.ConclusionThe use of FC did not show survival benefits but reduced transfusion requirements in traumatic massive hemorrhages, highlighting a need for future investigations. In the future, individualized goal-directed transfusion with FC may play a significant role in treating massive bleeding.Level of evidenceIV, retrospective study having more than one negative criterion.
The potential of growing soybean in Saskatchewan and its irrigation water needs under climate change scenarios—a modelling study
Authors: Qian Budong , Bonsal Barrie , Jing Qi , Smith Ward , Jégo Guillaume , Zhang Yinsuo , Brannen Rosa , Grant Brian , Crépeau Marianne 
Published: January 2024

The soybean industry in Canada is seeking opportunities to expand cultivation due to economic and environmental benefits of growing soybean. Climate projections indicate that soybean expansion into Saskatchewan would be possible with the increases in the available crop heat units under a future warmer climate; however, crop water availability could limit yields. Using a crop growth model, we simulated soybean yields within the Canadian Regional Agricultural Model regions in Saskatchewan for the near-term (2030s), mid-term (2050s), and distant future (2070s) periods under different climate scenarios. Soybean yields were simulated without water stress (potential yield), with water stress (rainfed yield), and under full and partial irrigation scenarios. Irrigation water needs were estimated under the irrigation scenarios and irrigation water availability was discussed. Our results suggest that reasonable and likely more profitable yields (∼2000–2500 kg ha−1) can be achieved under rainfed conditions in the Black soil zone neighbouring Manitoba but soybean production would be less favourable in the Dark Brown soil zone and least favourable in the Brown soil zone. Northeastern regions in the Black soil zone were found to be suitable for growing soybean cultivars in the maturity group (MG) 0 in the distant future and MG 00 in the mid-term under the medium–high greenhouse gas emission scenarios. Soybean would still not be suitable in the northwestern region. Our results indicate that regions in central Saskatchewan requiring 120–170 mm of irrigation are more likely to benefit from the proposed Lake Diefenbaker Irrigation Projects in the future.
Magnetic monopole meets primordial black hole: an extended analysis
Authors: Zhang Chen , Zhang Xin 
Published: January 2024

AbstractWe investigate gravitational capture of magnetic monopoles by primordial black holes (PBH) that evaporate before Big Bang Nucleosynthesis (BBN), a hypothetical process which was once proposed as an alternative solution to the monopole problem. Magnetic monopoles produced in phase transitions of a grand or partially unified gauge theory are considered. We prove analytically that for all extended PBH mass functions that preserve radiation domination, it is impossible to reduce the monopole abundance via gravitational capture by PBHs to values significantly below the one set by monopole annihilation (or below its initial abundance if it is smaller), regardless of the nature of the capture process (diffusive or non-diffusive). Therefore, the monopole problem cannot be solved by PBH capture in a radiation-dominated era in the early universe.
Thin accretion disk signatures in hybrid metric-Palatini gravity
Authors: Dyadina Polina , Avdeev Nikita 
Published: January 2024

AbstractIn the present work, accretion onto a static spherically symmetric black hole in the hybrid metric-Palatini gravity is considered. The Novikov–Thorne model for a relativistic thin accretion disk is used. The energy flux, temperature distribution, emission spectrum and energy conversion efficiency of accretion disks around such black holes are numerically calculated. A comparison with the results for a Schwarzschild black hole is made and conclusions about the viability of the model are drawn. As a result, it is obtained that the accretion disks around black holes in hybrid metric-Palatini gravity are colder and less luminous than in general relativity.
Hietarinta Chern–Simons supergravity and its asymptotic structure
Authors: Concha Patrick , Fierro Octavio , Rodríguez Evelyn 
Published: January 2024

AbstractIn this paper we present the Hietarinta Chern–Simons supergravity theory in three space-time dimensions which extends the simplest Poincaré supergravity theory. After approaching the construction of the action using the Chern–Simons formalism, the analysis of the corresponding asymptotic symmetry algebra is considered. For this purpose, we first propose a consistent set of asymptotic boundary conditions for the aforementioned supergravity theory whose underlying symmetry corresponds to the supersymmetric extension of the Hietarinta algebra. We then show that the corresponding charge algebra contains the super-$${{\mathfrak {bms}}}_{3}$$

bms
3

algebra as subalgebra, and has three independent central charges. We also show that the obtained asymptotic symmetry algebra can alternatively be recovered as a vanishing cosmological constant limit of three copies of the Virasoro algebra, one of which is augmented by supersymmetry.
Gravity Spy: lessons learned and a path forward
Authors: Zevin Michael , Jackson Corey B. , Doctor Zoheyr , Wu Yunan , Østerlund Carsten , Johnson L. Clifton , Berry Christopher P. L. , Crowston Kevin , Coughlin Scott B. , Kalogera Vicky , Banagiri Sharan , Davis Derek , Glanzer Jane , Hao Renzhi , Katsaggelos Aggelos K. , Patane Oli , Sanchez Jennifer , Smith Joshua , Soni Siddharth , Trouille Laura , Walker Marissa , Aerith Irina , Domainko Wilfried , Baranowski Victor-Georges , Niklasch Gerhard , Téglás Barbara 
Published: January 2024

AbstractThe Gravity Spy project aims to uncover the origins of glitches, transient bursts of noise that hamper analysis of gravitational-wave data. By using both the work of citizen-science volunteers and machine learning algorithms, the Gravity Spy project enables reliable classification of glitches. Citizen science and machine learning are intrinsically coupled within the Gravity Spy framework, with machine learning classifications providing a rapid first-pass classification of the dataset and enabling tiered volunteer training, and volunteer-based classifications verifying the machine classifications, bolstering the machine learning training set and identifying new morphological classes of glitches. These classifications are now routinely used in studies characterizing the performance of the LIGO gravitational-wave detectors. Providing the volunteers with a training framework that teaches them to classify a wide range of glitches, as well as additional tools to aid their investigations of interesting glitches, empowers them to make discoveries of new classes of glitches. This demonstrates that, when giving suitable support, volunteers can go beyond simple classification tasks to identify new features in data at a level comparable to domain experts. The Gravity Spy project is now providing volunteers with more complicated data that includes auxiliary monitors of the detector to identify the root cause of glitches.
Dynamic Fabry-Pérot cavity stabilization technique for atom-cavity experiments
Authors: Dinesh S. P. , Thakar V. R. , Gokul V. I. , Bahuleyan Arun , Rangwala S. A. 
Published: January 2024

AbstractWe present a stabilization technique developed to lock and dynamically tune the resonant frequency of a moderate finesse Fabry-Pérot (FP) cavity used in precision atom-cavity quantum electrodynamics (QED) experiments. Most experimental setups with active stabilization either operate at one fixed resonant frequency or use transfer cavities to achieve the ability to tune the resonant frequency of the cavity. In this work, we present a simple and cost-effective solution to actively stabilize an optical cavity while achieving a dynamic tuning range of over 100 MHz with a precision under 1 MHz. Our unique scheme uses a reference laser locked to an electro-optic modulator (EOM) shifted saturation absorption spectroscopy (SAS) signal. The cavity is locked to the PDH error signal obtained from the dip in the reflected intensity of this reference laser. Our setup provides the feature to efficiently tune the resonant frequency of the cavity by only changing the EOM drive without unlocking and re-locking either the reference laser or the cavity. We present measurements of precision control of the resonant cavity frequency and vacuum Rabi splitting (VRS) to quantify the stability achieved and hence show that this technique is suitable for a variety of cavity QED experiments.
The Effects of Black Raspberry as a Whole Food–Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers
Authors: Chen Kun-Ming , Sun Yuan-Wan , Krebs Nicolle M. , Reinhart Lisa , Sun Dongxiao , Liao Jiangang , Cook Rachel , Bond Paige Elizabeth , Mallery Susan R. , El-Bayoumy Karam 
Published: January 2024

Abstract

Cigarette smoke is a rich source of free radicals that can promote oxidative stress and carcinogenesis, including head and neck squamous cell carcinoma (HNSCC) development; importantly, 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-iso-prostaglandin F2α (8-isoprostane) are biomarkers of oxidative stress. Several mechanisms, including the antioxidant properties of black raspberry (BRB), account for their chemopreventive effects. In the present clinical trial, we tested the hypothesis that BRB administration reduces biomarkers levels of oxidative stress in buccal cells and urine of smokers. One week after enrolling 21 smokers, baseline buccal cells and urine samples were collected before the administration of BRB lozenges for 8 weeks (5/day, 1 gm BRB/lozenge). Buccal cells and urine samples were collected at the middle and the end of BRB administration. The last samples were collected after the BRB cessation (washout period). We analyzed levels of 8-oxodG and 8-isoprostane (LC/MS-MS), urinary cotinine (ELISA), and creatinine (spectrophotometry). BRB significantly reduced the levels of 8-oxodG by 17.08% (P = 0.00079) in buccal cells and 12.44% (P = 0.034) in urine at the middle of BRB administration as compared with baseline; the corresponding values at the end of BRB administration were 16.46% (P = 0.026) in buccal cells and 25.72% (P = 0.202) in urine. BRB had no significant effect on the levels of urinary 8-isoprostane. BRB's capacity to inhibit 8-oxodG formation of smokers’ buccal cells and urine is clearly evident and the reduction in 8-oxodG suggests that antioxidant abilities are central to BRB's HNSCC chemopreventive properties.

Prevention Relevance:
Cigarette smoke contains highly active components namely free radicals that can promote oxidative stress and oral cancer. We found that black raspberry (BRB) inhibited the formation of oxidative stress markers in the oral cavity and urine of smokers suggesting the antioxidant abilities of BRB in preventing oral cancer.
An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype
Authors: Zhang Yaochuan , Song Yifu , Wang Xiaoliang , Shi Mengwu , Lin Yibin , Tao Dongxia , Han Sheng 
Published: January 2024

Abstract
Extensive infiltration by tumor-associated macrophages (TAM) in combination with myeloid-derived suppressor cells constitute the immunosuppressive microenvironment and promote the malignant phenotype of gliomas. The aggressive mesenchymal (MES)-subtype glioma stem cells (GSC) are prominent in the immunosuppressive microenvironment of gliomas. However, the underlying immune-suppressive mechanisms are still unknown. The current study showed that the antitumor immune microenvironment was activated in glioma in Nfat1−/− mice, suggesting induction of the immune-suppressive microenvironment by nuclear factor of activated T cells-1 (NFAT1). In TAMs, NFAT1 could upregulate the transcriptional activity of complement 3 (C3) and increase the secretion of C3a, which could then bind to C3aR and promote M2-like macrophage polarization by activating TIM-3. Simultaneously, C3a/C3aR activated the Ca2+-NFAT1 pathway, forming a positive feedback loop for the M2-like polarization of TAMs, which further promoted the MES transition of GSCs. Finally, disruption of this feedback loop using a C3aR inhibitor significantly inhibited glioma growth both in vitro and in vivo. The current study demonstrated that a NFAT1-C3a-C3aR positive feedback loop induces M2-like TAMs and further promotes the malignant phenotype of GSCs, which might be the potential therapeutic target for glioma.
The Immune Suppressor IGSF1 as a Potential Target for Cancer Immunotherapy
Authors: Koh Dong-In , Lee Minki , Park Yoon Sun , Shin Jae-Sik , Kim Joseph , Ryu Yea Seong , Lee Jun Hyung , Bae Seunggeon , Lee Mi So , Hong Jun Ki , Jeong Hong-Rae , Choi Mingee , Hong Seung-Woo , Kim Dong Kwan , Lee Hyun-kyung , Kim Bomi , Yoon Yoo Sang , Jin Dong-Hoon 
Published: January 2024

Abstract
The development of first-generation immune-checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 ushered in a new era in anticancer therapy. Although immune-checkpoint blockade therapies have shown clinical success, a substantial number of patients yet fail to benefit. Many studies are under way to discover next-generation immunotherapeutic targets. Immunoglobulin superfamily member 1 (IGSF1) is a membrane glycoprotein proposed to regulate thyroid function. Despite containing 12 immunoglobin domains, a possible role for IGSF1, in immune response, remains unknown. Here, our studies revealed that IGSF1 is predominantly expressed in tumors but not normal tissues, and increased expression is observed in PD-L1low non–small cell lung cancer (NSCLC) cells as compared with PD-L1high cells. Subsequently, we developed and characterized an IGSF1-specific human monoclonal antibody, WM-A1, that effectively promoted antitumor immunity and overcame the limitations of first-generation immune-checkpoint inhibitors, likely via a distinct mechanism of action. We further demonstrated high WM-A1 efficacy in humanized peripheral blood mononuclear cells (PBMC), and syngeneic mouse models, finding additive efficacy in combination with an anti–PD-1 (a well-characterized checkpoint inhibitor). These findings support IGSF1 as an immune target that might complement existing cancer immunotherapeutics.
Multigenerational effect of seaweed or selenium enriched substrates on nutritional composition of black soldier fly (Hermetia illucens)
Authors: Ottoboni M. , Ferrari L. , Bonilauri P. , Defilippo F. , Grisendi A. , Della Porta M. , Cazzola R. , Pinotti L. 
Published: January 2024

Abstract
Selenium (Se) is an essential trace element for livestock. To ensure an adequate intake is achieved, several supplementation sources have been studied targeting the different animal species. Although Se-enriched yeast remains one of the main sources of organic Se, other emerging and innovative sources, such as Se-enriched insects, could be useful for their potential use in animal nutrition. The purpose of this work was to study the effects of including algae ad/or Se in the rearing substrate of black soldier fly larvae (BSFL), where an absolute lack of information regarding nutritional compositional and multigenerational effect was identified. In this study, BSFL were reared on three different substrates: (1) a control substrate (CTR diet) of plant-ingredients (Gainesville diet), and (2) Ascophyllum nodosum diet (AN30%), with 30% substitution of the alfalfa meal with the brown algae and iii) a Se diet, where the CTR diet was fortified with 0.3 mg/kg of Se. All experiments were carried out under dark condition, at 25 °C with 70% relative humidity. The inclusion of algae seems to lengthen both larval and development time, while only minor effects were observed with the inclusion of Se in the diet. The multigenerational trial, however, showed that the substrates hereby studied (AN30% and Se diet) both affect the future generation of BSF, with considerably lower both egg-laying performance and hatching performance than in the CTR group. However, more studies are necessary to determine the effect of algae and Se on reproductive performance of BSF as well as the proximate composition of BSFL.
18. Artificial Intelligence and the Symphony Orchestra
Authors: Laidlow Robert 
Published: January 2024

This chapter documents a process of practice-based research concerning the relationship between artificial intelligence and classical music. I argue that classical music (as an industry) is well placed o answer salient questions that the age of artificial intelligence demands we consider. The relationship is explored through three themes, which are:
1. The relationship between the future and the past
2. The idea of “authenticity”
3. The notion of music as an abstract artform that can or cannot be reduced to data alone
Using these thematic areas as a bedrock, the case study will discuss the three- movement work Silicon, written for the BBC Philharmonic Orchestra. Drawing from my own practice and views the case study will explore how this new technology affects, and will affect, the way an orchestra interacts with a composer, and how orchestral music can be used to explore technology that has an increasingly profound effect on all aspects of our day-to-day lives. Alongside theoretical and aesthetic ties between classical music and artificial intelligence, practical methodologies for utilising artificial intelligence as part of the creative process will be explored. This includes the benefits and limitations of using artificial intelligence to create or develop musical material, long-term structures, or novel synthesized instruments, and also some compositional methodologies I have developed to magnify or mitigate the effect of artificial intelligence on a large-scale work.