bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human leucocyte antigens and Japanese patients with polymyalgia rheumatica: the protective effect ofDRB1*09:01
Authors: Nogi Shinichi , Oka Shomi , Higuchi Takashi , Furukawa Hiroshi , Shimada Kota , Azuma Takanori , Sugiyama Takao , Hirano Fuminori , Okamoto Akira , Fujimori Misuzu , Horai Yoshiro , Ihata Atsushi , Hashimoto Atsushi , Komiya Akiko , Matsui Toshihiro , Fukui Naoshi , Katayama Masao , Migita Kiyoshi , Tohma Shigeto 
Published: January 2024

ObjectiveThe hallmarks of the chronic inflammatory disease polymyalgia rheumatica (PMR) include pain, and morning stiffness in areas of the neck, shoulder and pelvic girdle. The human leucocyte antigen (HLA) gene was reported to be an important risk factor for PMR, but it has not been analysed precisely, especially in populations other than Europeans.MethodsGenotyping ofDRB1andDQB1was performed in Japanese PMR patients (n=270) and controls (n=413). Associations between allele carrier and genotype frequencies were determined for PMR.ResultsDRB1*04:05was associated with a predisposition to PMR (p=0.0006,Pc=0.0193, OR 1.85, 95% CI 1.31 to 2.62).DRB1*09:01was associated with protection against PMR (p=1.46×10−5,Pc=0.0004, OR 0.40, 95% CI 0.26 to 0.61). A shared epitope (SE) associated with PMR (p=3.07×10−6, OR 2.11, 95% CI 1.54 to 2.88).DQB1*03:03(p=0.0010,Pc=0.0140, OR 0.52, 95% CI 0.35 to 0.77) was associated with protection against PMR andDQB1*04:01(p=0.0009,Pc=0.0140, OR 1.82, 95% CI 1.28 to 2.58) was associated with predisposition to PMR. A gene dosage effect was observed forDRB1*09:01andDQB1*03:03, but not forDRB1*04:05,SE orDQB1*04:01. Haplotype and logistic regression analyses suggested a protective effect forDRB1*09:01.ConclusionThis study is the first to demonstrate predisposing associations ofDRB1*04:05,SE, andDQB1*04:01, and protective associations ofDRB1*09:01andDQB1*03:03with PMR in Japanese patients. Our data indicateHLAhas predisposing and protective effects on the pathogenesis of PMR.
Predictors of direct oral anticoagulant concentrations in the trauma population
Authors: Perkins Louis , Adams Laura , Lerner Dmitri , Santorelli Jarrett , Smith Alan M , Kobayashi Leslie 
Published: January 2024

IntroductionDirect oral anticoagulant (DOAC) use is becoming more prevalent in patients presenting after trauma. We sought to identify the prevalence and predictors of subtherapeutic and therapeutic DOAC concentrations and hypothesized that increased anti-Xa levels would correlate with increased risk of bleeding and other poor outcomes.MethodsA retrospective cohort study of all trauma patients on apixaban or rivaroxaban admitted to a level 1 trauma center between January 2015 and July 2021 was performed. Patients were excluded if they did not have a DOAC-specific anti-Xa level at presentation. Therapeutic levels were defined as an anti-Xa of 50 ng/mL to 250 ng/mL for rivaroxaban and 75 ng/mL to 250 ng/mL for apixaban. Linear regression was used to identify correlations between study variables and anti-Xa level, and binomial logistic regression was used to test the association of anti-Xa level with outcomes.ResultsThere were 364 trauma patients admitted during the study period who were documented to be on apixaban or rivaroxaban. Of these, 245 patients had anti-Xa levels measured at admission. The population was 53% woman, with median age of 78 years, and median Injury Severity Score of 5. In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. Female sex, increased age, decreased height and weight, and lower estimated creatinine clearance were associated with higher anti-Xa levels at admission. There was no correlation between anti-Xa level and the need for transfusion or reversal agent administration, admission diagnosis of intracranial hemorrhage (ICH), progression of ICH, hospital length of stay, or mortality.ConclusionsAnti-Xa levels in trauma patients on DOACs vary widely; female patients who are older, smaller, and have decreased kidney function present with higher DOAC-specific anti-Xa levels after trauma. We were unable to detect an association between anti-Xa levels and clinical outcomes.Level of evidenceIII—Prognostic and Epidemiological.
Access to evidence-based care: a systematic review of trauma and surgical literature costs across resource settings
Authors: Wojick Megan , Conner Hannah , Farley Ashley , Huaman Eduardo , Luyo Marianne , Thomas-Pate Sam , LaGrone Lacey 
Published: January 2024

BackgroundEvidence-based medicine has become the foundation for surgeons around the world to provide the most effective surgical care. However, the article processing charges (APCs) and subscription fees for surgical journals may be a barrier, particularly for those in low-income and middle-income countries (LMICs).ObjectivesThe objective of this study was to define the current options for producers and consumers of surgical literature, inclusive of trauma, across resource settings.Data sourcesThe Web of Science Core Collection database.Study appraisal and synthesis methodsA complete list of journals publishing surgical content between 2019 and 2020 was compiled. The most frequently indexed journals were reviewed using the individual journal websites to extract the type of access (ie, open, closed, hybrid), impact factors, publication languages, APCs, subscription pricing, and any discounts listed.ResultsThe literature search revealed 4759 unique journals. The 500 most frequently indexed were reviewed. The mean APC for a fully open access surgical journal was US$1574 and for a hybrid surgical journal was US$3338. The average costs for a 1-year subscription in a hybrid surgical journal were US$434 and US$1878 for an individual and institution, respectively. When considering purchasing power parity, APCs and subscription costs ranged from 2 to 15 times more expensive in LMICs when compared with those in the USA.LimitationsPrimary search term was in English only, and only peer-reviewed journal articles were reviewed.Conclusions or implications of key findingsAlthough initiatives exist to support peer-reviewed journals in LMICs, there is an exorbitant cost for authors in these countries, as well as those in high-income countries that are not affiliated with a large institution, to either publish in, or access, a majority of surgical journals. Efforts to lower the overall cost of publishing must be made to provide greater access to medical literature.PROSPERO registration numberCRD4202140227.Level of evidenceLevel IV.
Maximum mass of an anisotropic compact object admitting the modified Chaplygin equation of state in Buchdahl-I metric
Authors: Bhattacharjee D. , Chattopadhyay P. K. 
Published: January 2024

AbstractIn this article, a new class of exact solutions for anisotropic compact objects is presented. Admitting the modified Chaplygin equation of state $$p=H\rho -\frac{K}{\rho ^{n}}$$

p
=
H
ρ
-

K

ρ
n

, where H, K and n are constants with $$0<n\le 1$$

0
<
n
≤
1

, and employing the Buchdahl-I metric within the framework of the general relativity stellar model is obtained. Recent observations on pulsars and GW events reveal that the observed maximum mass of compact stars detected so far is approximately $$2.59^{+0.08}_{-0.09}~M_{\odot }$$

2
.

59

-
0.09

+
0.08

M
⊙

. Since massive stars cannot be supported by a soft equation of state, a constraint of the equation of state must hold. The choice of a suitable equation of state for the interior matter of compact objects may predict useful information compatible with recent observations. TOV equations have been solved using the modified Chaplygin equation of state to find the maximum mass in this model. In particular, the theory can achieve $$3.72~M_{\odot }$$

3.72

M
⊙

, when $$H=1.0$$

H
=
1.0

, $$K=10^{-7}$$

K
=

10

-
7

and $$n=1$$

n
=
1

. The model is suitable for describing the mass of pulsars PSR J2215+5135 and PSR J0952-0607 and the mass $$2.59^{+0.08}_{-0.09}~M_{\odot }$$

2
.

59

-
0.09

+
0.08

M
⊙

of the companion star in the GW 190814 event. The $$3.72~M_{\odot }$$

3.72

M
⊙

is hardly achievable theoretically in general relativity considering fast rotation effects too. To check the physical viability of this model, we have opted for the stability analysis and energy conditions. We have found that our model satisfies all the necessary criteria to be a physically realistic model.
The Cara Cura intrusive complex, Neuquén Basin, Argentina: a field analogue of a whole igneous petroleum system
Authors: Palma J. Octavio , Rabbel Ole , Spacapan Juan B. , Ruiz Remigio , Galland Olivier 
Published: January 2024

Abstract
This contribution presents a detailed geological study of a well-exposed igneous petroleum system at Sierra de Cara Cura, Neuquén Basin, Argentina, which consists of sills, dykes, laccoliths and hybrid intrusion morphologies. The size of the exposed intrusive complex (19 km in north–south direction) is similar to those of sill-clusters hosting producing oil fields of the nearby Río Grande Valley. Most sills (>80%) are preferentially emplaced in the organic-rich rocks such as Vaca Muerta and Agrio Formations. Sills are extensively fractured and represent potentially good fractured hydrocarbon reservoirs. We document several fracturing mechanisms that can lead to heterogeneous fracture distribution. Laccoliths represent very different igneous reservoirs with a typical zonation: the core of the laccoliths are massive and poorly fractured, whereas the rims consist of a breccia formed during laccolith emplacement. The Vaca Muerta and Agrio Formations are thermally altered by the cooling of the sills. The deep parts of the outcropping laccoliths likely altered thermally the shale formations they were emplaced in. Hydrogen Index (HI) and Transformation Ratio (TR) of the organic matter are the best parameters to determine the thickness of the thermal aureole. The Sierra de Cara Cura appears as a world-class field analogue of igneous petroleum systems.
The Concept of Class Invariant in Object-oriented Programming
Authors: Meyer Bertrand , Arkadova Alisa , Kogtenkov Alexander 
Published: January 2024

Class invariants—consistency constraints preserved by every operation on objects of a given type—are fundamental to building, understanding, and verifying object-oriented programs. For verification, however, they raise difficulties, which have not yet received a generally accepted solution. The present work introduces a proof rule meant to address these issues and allow verification tools to benefit from invariants.
It clarifies the notion of invariant and identifies the three associated problems: callbacks, furtive access, and reference leak. As an example, the 2016 Ethereum DAO bug, in which $50 million was stolen, resulted from a callback invalidating an invariant.
The discussion starts with a simplified model of computation and an associated proof rule, demonstrating its soundness. It then removes one by one the three simplifying assumptions, each removal raising one of the three issues and leading to a corresponding adaptation to the proof rule. The final version of the rule can tackle tricky examples, including “challenge problems” listed in the literature.
Combined Prognostic Impact of Low Muscle Mass and Hypoalbuminemia in Patients Hospitalized for Heart Failure: A Retrospective Cohort Study
Authors: Mirzai Saeid , Sarnaik Kunaal S. , Persits Ian , Martens Pieter , Estep Jerry D. , Chen Po‐Hao , Tang W. H. Wilson 
Published: January 2024

Background
Sarcopenia and hypoalbuminemia have been identified as independent predictors of increased adverse outcomes, including mortality and readmissions, in hospitalized older adults with acute decompensated heart failure (ADHF). However, the impact of coexisting sarcopenia and hypoalbuminemia on morbidity and death in adults with ADHF has not yet been investigated. We aimed to investigate the combined effects of lower muscle mass (LMM) as a surrogate for sarcopenia and hypoalbuminemia on in‐hospital and postdischarge outcomes of patients hospitalized for ADHF.

Methods and Results

A total of 385 patients admitted for ADHF between 2017 and 2020 at a single institution were retrospectively identified. Demographic and clinical data were collected, including serum albumin levels at admission and discharge. Skeletal muscle indices were derived from semi‐automated segmentation software analysis on axial chest computed tomography at the twelfth vertebral level. Our analysis revealed that patients who had LMM with admission hypoalbuminemia experienced increased diagnoses of infection and delirium with longer hospital length of stay and more frequent discharge to a facility. Upon discharge, 27.9% of patients had higher muscle mass without discharge hypoalbuminemia (reference group), 9.7% had LMM without discharge hypoalbuminemia, 38.4% had higher muscle mass with discharge hypoalbuminemia, and 24.0% had LMM with discharge hypoalbuminemia; mortality rates were 37.6%, 51.4%, 48.9%, and 63.2%, respectively. 1‐ and 3‐year mortality risks were highest in those with LMM and discharge hypoalbuminemia; this relationship remained significant over a median 23.6 (3.1–33.8) months follow‐up time despite multivariable adjustments (hazard ratio, 2.03 [95% CI, 1.31–3.16];
P
=0.002).

Conclusions
Hospitalization with ADHF, LMM, and hypoalbuminemia portend heightened mortality risk.
Referral of Pediatric Moyamoya for Revascularization: Financial and Quality Data Supporting Private Insurer Approval for Out‐of‐Network Care
Authors: Rangwala Shivani D. , Singh Nikita , Judge Jennifer , Isibor Christopher , McClain Craig D. , Lehman Laura L. , See Alfred P. , Orbach Darren B. , Smith Edward R. 
Published: January 2024

Background
Moyamoya is a rare arteriopathy affecting the intracranial circulation with a risk of stroke in the pediatric population. High‐volume centers provide improved outcomes after surgical revascularization compared with low‐volume centers. However, private insurers are often reluctant to approve care out‐of‐network. We hypothesized that rare diseases that can be treated in a single procedure, such as revascularization for moyamoya, can yield improved clinical outcomes with substantial cost savings to insurance companies when approved for care at high‐volume centers of excellence.

Methods

Longitudinal deidentified data of pediatric patients undergoing surgical revascularization for moyamoya from January 2018 to December 2020 (N = 125) were obtained from national commercial insurers by an independent third‐party analytics core. Patients were selected according to
International Classification of Diseases, Tenth Revision
(
ICD‐10
) diagnosis and procedure codes. For a 9‐month episode, clinical and cost outcome metrics were compared across centers, with patients from the highest volume center designated as the primary cohort.

Results
Patients in the primary cohort were on average younger at time of surgery, with greater medical comorbidities, yet exhibited decreased postoperative complications and fewer unplanned readmissions. The primary cohort had an overall 42% lower expense compared with patients treated at other single institution health systems ($89 000 versus $153 000). The primary cohort minimized out‐of‐network costs with implementation of a partnership care model, using local resources for preoperative workup in 68% of episodes, compared with only 8% of episodes at a comparator high‐volume center.

Conclusion
Implementation of a partnership model takes advantages of the surgical resources of a high‐volume center while maximizing local resource use for preoperative and postoperative care. Referral to high‐volume centers for pediatric moyamoya revascularization provides both improved outcomes for the patients and substantial cost savings for the insurers. These data suggest the development of high‐volume centers of excellence for select conditions requiring neurosurgical treatment confer benefit to both patients and insurers, even in cases of out‐of‐network care.
Dandelion Rebellion: Creating Crip Natures
Authors: O’Neill Cynthia 
Published: January 2024

Abstract
Inspired by the field of eco-crip theory, Dandelion Rebellion is the crip author’s art-as-research project focused on accessible nature, environmentalism, and activism for weedy species such as the dandelion. Drawing on relationships between dandelions and disabilities, Dandelion Rebellion investigates urban nature and examines multispecies relations and responsibility. Accessibility is central to this project’s design, participation, and conceptual process in digital and analog forms. Even as this project practices a model of accessibility, it also envisions a more fundamental reconceptualization of access called crip nature.
Unveiling Creative Economy Resilience in Indonesia amidst the Global Pandemic
Authors: Kusumaningrum Demeiati Nur , Maulana Prasetya Dion , Farid Styo Wibowo Novin 
Published: January 2024

Abstract
In light of the evolving post-COVID-19 global development agenda, this article delves into the conceptualization of resilience within the creative economy as portrayed in public discourse. Using media analysis, the article scrutinizes discourse patterns evident in Jawa Pos, Indonesia’s premier media outlet, from 2020 to 2021. The insights presented are corroborated by a comprehensive literature review and an examination of official government reports. This study examines seven creative industries that dominated public discourse during the pandemic: games, software applications, film, video production, art performance, culinary arts, and crafts. Digital platforms have invigorated sectors such as gaming, culinary arts, crafts, and video content; furthermore, local tourism initiatives have been instrumental in catalysing economic rejuvenation in areas such as the culinary arts, crafts, and art performance. This analysis encourages further studies on the resilience of the creative economy.
Enhancing Global Food Security: Opportunities for the American Meteorological Society
Authors: Stuart Lauren , Hobbins Mike , Niebuhr Emily , Ruane Alex C. , Pulwarty Roger , Hoell Andrew , Thiaw Wassila , Rosenzweig Cynthia , Muñoz-Arriola Francisco , Jahn Molly , Farrar Michael 
Published: January 2024

Abstract
Food security is a key pillar of environmental security yet remains one of the world’s greatest challenges. Its obverse, food insecurity, negatively impacts health and well-being, drives mass migration, and undermines national security and global sustainable development. Ensuring food security is a delicate balance of myriad concerns within the atmospheric and Earth sciences, agronomy and agriculture engineering, social sciences, economics, monitoring, and policymaking. A Food Security Presidential Session at the American Meteorological Society’s (AMS) 2022 Annual Meeting brought together experts across disciplines to tackle issues at the nexus of weather, climate, and food security. The starkest takeaway was the realization that, despite its importance and clear roles for the atmospheric and climate sciences, food security has not been a focus for the AMS community. The aim of this paper is to build on the perspectives shared by this expert panel and to identify overlapping issues and key points of intersection between the food-security community and AMS. We examine 1) the interactions between weather, climate, and the food system and how they influence food security; 2) the time and spatial scales of food security decision support that match weather and climate phenomena; 3) the role of both providers and users of information as well as decision-makers in improving research to operations for food security; and 4) the opportunities for the AMS community to address food security. We conclude that, moving forward, the AMS community is well-positioned to scale up its engagement across the global food system to address existing scientific needs and technology gaps to improve global food security.
Investigation of interlayer toughening of carbon fiber composites using non-woven polyamide veils under different curing pressures
Authors: Narongdej Poom , Denk Jack , Barjasteh Ehsan 
Published: January 2024

Carbon fiber-reinforced composites have become increasingly favored in the aerospace and automotive sectors for their remarkable performance attributes. Nonetheless, their broader adoption is hindered by the concern of delamination. To address this limitation, our study delved into the influence of incorporating a thermoplastic toughening agent on the interlaminar fracture toughness (ILFT) of woven carbon fiber composites. Our investigation focused on the impact of diverse curing pressures on these composites, analyzing configurations both with and without an integrated non-woven polyamide (PA) veil. The PA veil was meticulously positioned within the central layer of a composite, combining benzoxazine and carbon fiber constituents. Our primary objective entailed optimizing curing conditions to enhance ILFT across both Mode-I and Mode-II fracture modes. Our findings unveiled that elevating curing pressure had a limited effect on ILFT in non-interleaved composites while interleaved samples exhibited substantial ILFT reductions under heightened curing pressure. Raising pressure from 1 atm to 3.5 atm caused approximately a 27% drop in the Mode-I strain energy release rate (GIC) value, and this reduction deepened to 42% at 7 atm. This highlighted the inverse relationship between increased curing pressure and GIC values in interleaved specimens, while non-interleaved counterparts experienced less pronounced changes. A parallel trend manifested in Mode-II ILFT, where escalated curing pressure correlated with diminished Mode-II strain energy release rate (GIIC) values. Interleaved samples suffered a notably more significant decline, attributed to resin content reduction caused by heightened pressure. This, in turn, compromised the bond between the PA veil and the matrix, facilitating the propagation of cracks within the composite. This ultimately culminated in significantly reduced GIC and GIIC values. Our study contributes valuable insights into optimizing the interlaminar fracture toughness of carbon fiber composites, shedding light on the complex interplay of curing conditions and material configurations.
BRCA mutation status and pathological characterization of breast cancer in Zhoushan Islands, China
Authors: Bao Shuhui , Sun Nini , Li Yaling , Shu Jiaojie , Xu Jing , Zhang Yong , Qiu Xia 
Published: January 2024

Objective To investigate BRCA1/ 2 gene mutations and their relationship with clinicopathological features in patients with breast cancer in Zhoushan Islands. Methods High-throughput whole-exome gene sequencing was used to detect BRCA1/ 2 mutations in 776 breast cancer patients in Zhoushan Islands. Results The BRCA1/ 2 mutation rate of breast cancer patients in Zhoushan Islands was 4.38% (34/776). BRCA1 mutations were significantly correlated with age, molecular type, and family history of breast and ovarian cancers. BRCA2 mutations were most commonly found in invasive lobular carcinoma. Moreover, the BRCA2 mutation rate of cancers with molecular type luminal B (receptor protein–tyrosine kinase [HER2]-negative) was also relatively high. Conclusion The rate of BRCA1/ 2 mutations in breast cancer patients from Zhoushan Islands is approximately 4.38%, and BRCA1 mutation is related to age, molecular type, and family history of breast and ovarian cancers.