bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treatStreptococcus pyogenesskin and soft tissue infection
Authors: Zou Zongsen , Obernuefemann Chloe L. P. , Singh Pardeep , Pinkner Jerome S. , Xu Wei , Nye Taylor M. , Dodson Karen W. , Almqvist Fredrik , Hultgren Scott J. , Caparon Michael G. 
Published: January 2024

ABSTRACTWe have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone scaffold that have antimicrobial activities against a broad-spectrum of Gram-positive pathogens. Here we examine the treatment efficacy of GmPcides using skin and soft tissue infection (SSTI) and biofilm formation models byStreptococcus pyogenes. Screening our compound library for minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations identified GmPcide PS757 as highly active againstS. pyogenes. Treatment ofS. pyogenesbiofilm with PS757 revealed robust efficacy against all phases of biofilm formation by preventing initial biofilm development, ceasing biofilm maturation and eradicating mature biofilm. In a murine model ofS. pyogenesSSTI, subcutaneous delivery of PS757 resulted in reduced levels of tissue damage, decreased bacterial burdens and accelerated rates of wound-healing, which were associated with down-regulation of key virulence factors, including M protein and the SpeB cysteine protease. These data demonstrate that GmPcides show considerable promise for treatingS. pyogenesinfections.
Chemical imaging unveils mitochondria as the major site of medicinal biguanide accumulation within cells
Authors: Wang Lei , Zeng Xianrong , Li Yanjie , Hao Wanyu , Yu Zijing , Yao Luxia , Zhang Yongdeng , Wang Zhaobin , Wu Lianfeng 
Published: January 2024

AbstractMetformin (MET), a commonly prescribed medication for managing type 2 diabetes, has demonstrated various beneficial effects beyond its primary anti-diabetic efficacy. However, the mechanism underlying MET activity and its distribution within organelles remain largely unknown. In this study, we integrate multiple technologies, including chemical labeling, immunostaining, and high-resolution microscopy imaging, to visualize the accumulation of MET in organelles of cultured cells. To achieve this objective, an alkynylated MET probe is developed that preserves biological activity similar to biguanide drugs. As determined by biorthogonal chemical labeling and imaging, the MET probe selectively localizes to substructures within cells, contrasting with its probe control. Furthermore, the MET probe can be competitively and efficiently washed out through biguanide administration, demonstrating the specific activity of this probe in monitoring the cellular dynamics of biguanide drugs. Our results indicate that the MET probe can reach near-saturated concentrations within two hours and is rapidly eliminated within an additional two hours once the exogenous source of the drug is removed. Furthermore, we reveal that the MET probe primarily accumulates in mitochondria, particularly within the mitochondrial matrix, and has a minor presence in other organelles, such as lysosomes and endosomes. Together, this study provides the first view of the MET subcellular localization and lays the foundation for future investigations on its molecular targets and mechanisms of action in promoting human health.
Curcumin Inhibits Zika Virus NS3 Helicase Activity
Authors: Kumar Ankur , Bhardwaj Aparna , Joshi Richa , Bhardwaj Taniya , Giri Rajanish 
Published: January 2024

ABSTRACTIn the last decades, many efforts have been put forward in search of inhibitors/drugs specific to ZIKV-infected patients. These inhibitors include approved drugs, natural products, nucleosides, small molecules, and many others to inhibit Zika virus replication in cell and mouse models. In this regard, natural product curcumin has been widely explored in various disease conditions and found to have inhibition potential against ZIKV replication as well. Further, we investigated its inhibitory ability against the ZIKV NS3 helicase. We found that the curcumin interacts with the NS3 helicase domain by forming stable contacts at NTPase and RNA binding sites during molecular dynamic simulation. Furthermore, curcumin inhibits NTPase activity of NS3 helicase with an IC50of 64.42 μM. Altogether, the mechanistic insight into the action of curcumin will enlighten further drug discovery research in finding novel molecules.
Sorafenib induces muscle wasting by disrupting the activity of distinct chromatin regulators
Authors: Khan Bushra , Lanzuolo Chiara , Rosti Valentina , Santarelli Philina , Pich Andreas , Kraft Theresia , Amrute-Nayak Mamta , Nayak Arnab 
Published: January 2024

SummaryAdverse effects of chemotherapies can outweigh the benefits in cancer patients. Various chemotherapeutics are linked to muscle wasting or cachexia, drastically reducing the chance of survivability of cancer patients. Insights into the molecular basis of chemotherapy-induced cachexia is an unmet need to improve the treatment strategies. Here, we investigated the tyrosine kinase inhibitor class of chemotherapeutic agents for their effects on muscle function. Sorafenib, but not Nilotinib and Imatinib, triggered cachexia. System-wide transcriptome and proteome analyses revealed that Sorafenib alters the global transcriptional program and proteostasis in muscle cells. Mechanistically, Sorafenib treatment reduced active epigenetic mark H3K4 methylation on distinct muscle-specific genes due to the defective chromatin association of SET1/A, a catalytic component of the SET1/MLL complex. It favored transcriptionally incompetent chromatin, characterized by diminished association with RNA polymerase II. The transcriptional reorientation led to disrupted sarcomere organization, calcium homeostasis, and mitochondrial respiration. Consequently, the contractile ability of muscle cells was severely compromised. Collectively, we identified an unanticipated transcriptional mechanism underlying Sorafenib-induced cachexia. Our findings hold the potential to strategize therapy regimens to minimize chemotherapy-induced cachexia and improve treatment outcomes.
ALS patient-derived motor neuron networks exhibit microscale dysfunction and mesoscale compensation rendering them highly vulnerable to perturbation
Authors: Fiskum Vegard , Winter-Hjelm Nicolai , Christiansen Nicholas , Sandvig Axel , Sandvig Ioanna 
Published: January 2024

SummaryAmyotrophic lateral sclerosis affects upper and lower motor neurons, causing progressive neuropathology leading to structural and functional alterations of affected neural networks long prior to development of symptoms. Certain genetic mutations, such as expansions inC9orf72, predispose motor neuron populations to pathological dysfunction. However, it is not known how underlying pathological predisposition affects structural and functional dynamics within vulnerable networks. Here, we studied micro-and mesoscale dynamics of ALS patient derived motor neuron networks over time. We show, for the first time, that ALS patient derived motor neurons with endogenous genetic predisposition develop classical ALS cytopathology in the form of cytoplasmic TDP-43 inclusions and self-organise into computationally efficient networks, albeit with functional hallmarks of higher metabolic cost compared to healthy controls. These hallmarks included microscale impairments and mesoscale compensation including increased centralisation of function. Moreover, we show that these networks are highly susceptible to transient perturbation by exhibiting induced hyperactivity.
Hybrid-nanofluid magneto-convective flow and porous media contribution to entropy generation
Authors: Mebarek-Oudina Fateh , Chabani Ines , Vaidya Hanumesh , Ismail Abdul Aziz I. 
Published: January 2024

Purpose
This paper aims to present a numerical study that investigates the flow of MgO-Al2O3/water hybrid nanofluid inside a porous elliptical-shaped cavity, in which we aim to examine the performance of this thermal system when exposed to a magnetic field via heat transfer features and entropy generation.

Design/methodology/approach
The configuration consists of the hybrid nanofluid out layered by a cold ellipse while it surrounds a non-square heated obstacle; the thermal structure is under the influence of a horizontal magnetic field. This problem is implemented in COMSOL multiphysics, which solves the related equations described by the “Darcy-Forchheimer-Brinkman” model through the finite element method.

Findings
The results illustrated as streamlines, isotherms and average Nusselt number, along with the entropy production, are given as functions of: the volume fraction, and shape factor to assess the behaviour of the properties of the nanoparticles. Darcy number and porosity to designate the impact of the porous features of the enclosure, and finally the strength of the magnetic induction described as Hartmann number. The outcomes show the increased pattern of the thermal and dynamical behaviour of the hybrid nanofluid when augmenting the concentration, shape factor, porosity and Darcy number; however, it also engenders increased formations of irreversibilities in the system that were revealed to enhance with the permeability and the great properties of the nanofluid. Nevertheless, this thermal enhanced pattern is shown to degrade with strong Hartmann values, which also reduced both thermal and viscous entropies. Therefore, it is advised to minimize the magnetic influence to promote better heat exchange.

Originality/value
The investigation of irreversibilities in nanofluids heat transfer is an important topic of research with practical implications for the design and optimization of heat transfer systems. The study’s findings can help improve the performance and efficiency of these systems, as well as contribute to the development of sustainable energy technologies. The study also offers an intriguing approach that evaluates entropy growth in this unusual configuration with several parameters, which has the potential to transform our understanding of complicated fluid dynamics and thermodynamic processes, and at the end obtain the best thermal configuration possible.
From intra-team conflict to interpersonal strain: the role of leader’s interpersonal modulation of emotional responses and sex
Authors: Santarpia Ferdinando Paolo , Sommovigo Valentina , Brecciaroli Sara , Consiglio Chiara , Borgogni Laura 
Published: January 2024

Purpose
By integrating the conservation of resources and the emotion-as-social-information theories, this study aims to question whether the leader’s effort to calm down when team members perceive intra-team conflict (ITC) may have a counterproductive effect on their interpersonal functioning. Specifically, the authors investigated whether team members with higher individual perceptions of ITC would be more likely to experience interpersonal strain (ISW) when their team leaders downregulate or suppress their emotional responses (i.e. high interpersonal modulation of emotional responses [MER]). A further objective of the study was to examine whether this exacerbating effect would be conditional on the leader’s sex.

Design/methodology/approach
Data were collected from 236 white collars nested in 48 teams (Msize = 6.23; SDsize = 2.69) and their respective team leaders (56.7% men) of a large organization providing financial services.

Findings
Multilevel model results showed that team members confronted with higher ITC experienced higher ISW levels, especially when the leader’s interpersonal modulation of team members’ emotional responses was high (vs low). This effect was stronger when the interpersonal modulation was enacted by women (vs men) team leaders.

Originality/value
This study moves an important step forward in the conflict and ISW literature, as it is the first to identify a leader’s MER and sex as key boundary conditions under which ITC is related to team members’ ISW. The implications of these findings for theory and practice are discussed.
Study on surface properties of coated WC-Co alloy based on laser reduction process
Authors: Yang Shucai , Wang Dawei , Xiao Zhanjun 
Published: January 2024

Purpose
The purpose is to explore the improvement mechanism of coating and laser micro-texture on the surface properties of cemented carbide, so as to give full play to the technical advantages of both and improve the overall surface properties of the material.

Design/methodology/approach
The surface hardness of the coating was measured by a microhardness tester, the surface element composition of the coating was tested by an energy spectrum analyzer and the phase was measured by an X-ray diffractometer to observe the surface morphology after the friction and wear experiment.

Findings
Laser will generate new oxide and nitride films on the surface of the coating, which will improve the hardness of the coating surface and the bonding strength between the coating and the substrate. The surface micro-texture can collect wear debris during the friction process, reduce abrasive wear and play a good role in inhibiting the expansion of the coating failure zone.

Originality/value
Most of the research on traditional laser coating is to process micro-texture first and then coating. This study is the opposite. In this paper, the modification effect of laser on the coating surface is explored, and the parameters of laser and coating are optimized, which paves the way for the subsequent milling experiments of textured coating tools.
Economic and governance drivers of global remittances: a comparative study of the UK, US, and UAE to India
Authors: Khan Imran 
Published: January 2024

Purpose
The paper aims to analyse the impact of economic and governance factors on remittance inflows to India from the UK, USA and UAE. India is globally recognised as the largest recipient of remittances.

Design/methodology/approach
Using a comprehensive time series data set spanning 1996 to 2022, the authors use an innovative non-linear autoregressive distributed lag model approach to examine the influence of economic growth, corruption control and employer availability in the three source countries on remittance inflows to India.

Findings
The results indicate that in the UAE, changes in economic growth and corruption control directly affect remittance outflows. However, the presence of employers in the UAE has minimal impact on remittance outflows to India. Regarding the UK, fluctuations in economic growth primarily drive remittance outflows to India. The effect of corruption control and employment opportunities on remittance outflows is marginal. In the USA, economic growth does not notably impact remittance outflows, whereas corruption control and employment opportunities significantly influence the outflows to India.

Originality/value
These findings have important implications for policymakers. Analysing macroeconomic factors from key remittance-sending nations offers valuable insights for Indian policymakers and their international counterparts to enhance remittance inflows. The study focuses on three countries that collectively contribute to about 50% of India's remittances, providing a unique contribution compared to the usual country-specific or regional focus in existing literature. Finally, leveraging these findings, NITI Aayog, an organisation dedicated to achieving India's sustainable development goals, can effectively monitor macroeconomic indicators related to significant remittance-sending countries.
Slow food and the slow food movement: a case study of consumer activism in Turkiye
Authors: Tokucoglu Yumusak Tuba , Yilmaz Kadri Gokhan , Deligonul Seyda Z. , Cavusgil Tamer 
Published: January 2024

PurposeThe slow food movement has become increasingly widespread globally in recent years. This paper focuses on explaining how Turkish cuisine, which has a deep-rooted history, meshes with the slow food movement and how this movement affects consumer behavior.Design/methodology/approachBased on expert opinion analysis with academics knowledgeable about the food industry and gastronomy, this paper explores how the slow food movement in Turkiye is evolving and how consumers perceive it. Content analysis was applied to the data obtained from the personal interviews.FindingsThe authors find that the slow food movement creates a strong brand image for businesses that rely on emphasizing the responsibility to the ecological system while appealing to the five senses of consumers. It already shows great potential even in emerging markets where typical household discretionary income is modest.Practical implicationsBased on key theories regarding all sales activism cases, the authors have offered insights into the dynamics, motivations and techniques of the case. Ensuring the preservation of the slow food movement, framing and creating associations need to be examined.Originality/valueSlow food is a movement that emerged against the standard, fast, tasty, but unhealthy products of the fast-food industry. It entails product variety, local flavors and preference for the single-flavor focus embedded in the fast-food movement. The movement started with considerations of gastronomy and later was institutionalized as a social movement phenomenon. Later, it expanded its base to activism, targeting various social issues.
Knowledge sovereignty: clearing the mental cobweb through library engagement
Authors: Durodolu Oluwole Olumide , Ibenne Samuel Kelechukwu 
Published: January 2024

Purpose
The purpose of this study is to evaluate knowledge sovereignty and its implication for clearing the mental cobweb through library engagement.

Design/methodology/approach
Review of literature

Findings
Knowledge sovereignty refers to people’s ability and aptitude to control, access and navigate information to enable them make informed decisions and channel their activities toward right choices. Library engagements within the new normal of knowledge sovereignty center on their knowledge-centric approach to create, scale, reframe and disseminate both new and existing knowledge to afford quick and gainful use within organizations and the larger society in a short period of time, thus eliminating the dilemma of digital information overload and its complexities, uncertainties and oftentimes, chaos.

Originality/value
This study comply with copyright requirement.
Geographical and gender inequalities in health sciences studies: testing differences in research productivity, impact and visibility
Authors: Goyanes Manuel , Demeter Márton , Háló Gergő , Arcila-Calderón Carlos , Gil de Zúñiga Homero 
Published: January 2024

PurposeGender and geographical imbalance in production and impact levels is a pressing issue in global knowledge production. Within Health Sciences, while some studies found stark gender and geographical biases and inequalities, others found little empirical evidence of this marginalization. The purpose of the study is to clear the ambiguity concerning the topic.Design/methodology/approachBased on a comprehensive and systematic analysis of Health Sciences research data downloaded from the Scival (Scopus/Scimago) database from 2017 to 2020 (n = 7,990), this study first compares gender representation in research productivity, as well as differences in terms of citation per document, citations per document view and view per document scores according to geographical location. Additionally, the study clarifies whether there is a geographic bias in productivity and impact measures (i.e. citation per document, citations per document view and view per document) moderated by gender.FindingsResults indicate that gender inequalities in productivity are systematic at the overall disciplinary, as well as the subfield levels. Findings also suggest statistically significant geographical differences in citation per document, citations per document view, and view per document scores, and interaction effect of gender over the relation between geography and (1) the number of citations per view and (2) the number of views per document.Originality/valueThis study contributes to scientometric studies in health sciences by providing insightful findings about the geographical and gender bias in productivity and impact across world regions.
A simulated natural heatwave perturbs bumblebee immunity and resistance to infection
Authors: Tobin Kerrigan B. , Mandes Rachel , Martinez Abraham , Sadd Ben M. 
Published: January 2024

Abstract

As a consequence of ongoing climate change, heatwaves are predicted to increase in frequency, intensity, and duration in many regions. Such extreme events can shift organisms from thermal optima for physiology and behaviour, with the thermal stress hypothesis predicting reduced performance at temperatures where the maintenance of biological functions is energetically costly. Performance includes the ability to resist biotic stressors, including infectious diseases, with increased exposure to extreme temperatures having the potential to synergise with parasite infection.

Climate change is a proposed threat to native bee pollinators, directly and through indirect effects on floral resources, but the thermal stress hypothesis, particularly pertaining to infectious disease resistance, has received limited attention. We exposed adult Bombus impatiens bumblebee workers to simulated, ecologically relevant heatwave or control thermal regimes and assessed longevity, immunity, and resistance to concurrent or future parasite infections.

We demonstrate that survival and induced antibacterial immunity are reduced following heatwaves. Supporting that heatwave exposure compromised immunity, the cost of immune activation was thermal regime dependent, with survival costs in control but not heatwave exposed bees. However, in the face of real infections, an inability to mount an optimal immune response will be detrimental, which was reflected by increased trypanosomatid parasite infections following heatwave exposure.

These results demonstrate interactions between heatwave exposure and bumblebee performance, including immune and infection outcomes. Thus, the health of bumblebee pollinator populations may be affected through altered interactions with parasites and pathogens, in addition to other effects of extreme manifestations of climate change.