bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction in healthy adults: Study protocol of a cross-over randomized controlled trial
Authors: Diez Gustavo G. , Martin-Subero Ignacio , Zangri Rosaria M. , Kulis Marta , Andreu Catherine , Blanco Ivan , Roca Pablo , Cuesta Pablo , García Carola , Garzón Jesús , Herradón Carlos , Riutort Miguel , Baliyan Shishir , Venero César , Vázquez Carmelo 
Published: November 2023

Introduction
The main objective of the study will be to evaluate the effects of two widely used standardized mindfulness-based programs [Mindfulness-Based Stress Reduction (MBSR) and Compassion Cultivation Training (CCT)], on epigenetic, neurobiological, psychological, and physiological variables.

Methods
The programs will be offered in an intensive retreat format in a general population sample of healthy volunteer adults. During a 7-day retreat, participants will receive MBSR and CCT in a crossover design where participants complete both programs in random order. After finishing their first 3-day training with one of the two programs, participants will be assigned to the second 3-day training with the second program. The effects of the MBSR and CCT programs, and their combination, will be measured by epigenetic changes (i.e., DNA methylation biomarkers), neurobiological and psychophysiological measures (i.e., EEG resting state, EKG, respiration patterns, and diurnal cortisol slopes), self-report questionnaires belonging to different psychological domains (i.e., mindfulness, compassion, well-being, distress, and general functioning), and stress tasks (i.e., an Arithmetic Stress Test and the retrieval of negative autobiographical memories). These measures will be collected from both groups on the mornings of day 1 (pre-program), day 4 (after finishing the first program and before beginning the second program), and day 7 (post-second program). We will conduct a 3-month and a 12-month follow-up using only the set of self-report measures.

Discussion
This study aims to shed light on the neurobiological and psychological mechanisms linked to meditation and compassion in the general population. The protocol was registered at clinicaltrials.gov (Identifier: NCT05516355; August 23, 2022).
Status of waste disposal of sharps outside medical institutions for patients with diabetes: A systematic review
Authors: Wu Jingwen , Wang Min , Yan Hong 
Published: November 2023

Objectives
As the number of people with diabetes increases, so does the amount of household-generated sharp waste, and incorrect sharp disposal methods can expose the public to needle stick injuries This systematic study assesses the relevant factors and current situation of the disposal of sharp waste in diabetes patients.

Methods
In this review, our study comprehensively searched PubMed, MEDLINE, Cochrane Library, EMBASE, Web of Science, and China Biomedical, Wanfang, and CNKI for the concepts of "sharps waste disposal" and "diabetes".

Result
In 12 identified articles, there are 4155 patients with diabetes. The findings highlight that diabetic patients have a positive attitude towards sharps waste disposal, but lack knowledge and practice of sharps waste disposal, and need to take appropriate measures to improve the rate of proper waste disposal before and during use. Patients with longer duration of diabetes are more likely to engage in inappropriate sharps disposal behaviors.

Conclusions
The findings emphasize that the majority of diabetic patients are unable to handle sharps safely, so more research is needed to find factors associated with sharps waste disposal in diabetic patients and to focus on sharps waste disposal behaviors in patients with longer duration of disease in future clinical practice.

Trial registration
PROSPERO ID. The review was registered on PROSPERO (registration number: CRD42023427592) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023427592.
Preclinical safety evaluation of continuous UV-A lighting in an operative setting
Authors: Guenter Rachael , Zheng-Pywell Rui , Herring Brendon , Murphy Madisen , Foote Jeremy , Benner Kevin , Rose J. Bart 
Published: November 2023

Background
Germicidal ultraviolet (UV-C) light has been shown as an effective modality for disinfection in laboratory settings and in the operative room. Traditionally, short-wavelength UV-C devices, which have previously been shown to cause DNA damage, are utilized only for disinfection in pre- and post-operative settings and are not continuously active during operations. Continuous use of intraoperative UV light has potential to decrease pathogens and subsequent surgical site infections (SSIs), which arise in approximately 5–15% of operative cases. SSIs are a significant determinant of patient morbidity, readmission rates, and overall cost. Therefore, a method of UV light disinfection with a low risk of DNA damage is needed so that greater antimicrobial protection can be afforded to patients during the entirety of their surgical procedures. A new disinfection device that harnesses longer-wavelength UV-A light to disinfect the surgical field throughout the entirety of the procedure, including pre- and post-operation has been developed.

Methods
This study aimed to determine if UV-A light administered intraoperatively was safe, as defined by the minimal presence of DNA damage and safe amounts of reflection upon medical personnel. Using in vitro models, we examined the differential impacts of UV-C and UV-A light on DNA damage and repair pathways. In a murine model, we looked at the production of DNA damage photoproduction in relation to UV-A versus UV-C exposure.

Results
Our results show UV-A light does not induce a significant amount of DNA damage at the cellular or tissue level. Furthermore, a preclinical porcine study showed that surgical personnel were exposed to safe levels of UV-A irradiance from an overhead UV-A light used during an operation. The amount of UV-A transmitted through surgical personal protective equipment (PPE) also remained within safe levels.

Conclusions
In conclusion, we found that UV-A may be safe for intraoperative use.
Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach
Authors: Mwila-Kazimbaya Katayi , Bosomprah Samuel , Chilyabanyama Obvious Nchimunya , Chisenga Caroline Cleopatra , Chibuye Mwelwa , Laban Natasha Makabilo , Simuyandi Michelo , Huffer Bert , Iturriza-Gomara Miren , Choy Robert K. M. , Chilengi Roma 
Published: November 2023

Background
Rotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and middle-income settings. Proposed factors include environmental enteric dysfunction (EED), malnutrition, and immune dysfunction. This study aimed to assess the effect of these factors on vaccine responses using a machine learning lasso approach.

Methods
Serum samples from two rotavirus clinical trials (CVIA 066 n = 99 and CVIA 061 n = 124) were assessed for 11 analytes using the novel Micronutrient and EED Assessment Tool (MEEDAT) multiplex ELISA. Immune responses to oral rotavirus vaccines (Rotarix, Rotavac, and Rotavac 5D) as well as a parenteral rotavirus vaccine (trivalent P2-VP8) were also measured and machine learning using the lasso approach was then applied to investigate any associations between immune responses and environmental enteric dysfunction, systemic inflammation, and growth hormone resistance biomarkers.

Results
Both oral and parenteral rotavirus vaccine responses were negatively associated with retinol binding protein 4 (RBP4), albeit only weakly for oral vaccines. The parenteral vaccine responses were positively associated with thyroglobulin (Tg) and histidine-rich protein 2 (HRP2) for all three serotypes (P8, P6 and P4), whilst intestinal fatty acid binding protein (I-FABP) was negatively associated with P6 and P4, but not P8, and soluble transferrin receptor (sTfR) was positively associated with P6 only.

Conclusion
MEEDAT successfully measured biomarkers of growth, systemic inflammation, and EED in infants undergoing vaccination, with RBP4 being the only analyte associated with both oral and parenteral rotavirus vaccine responses. Tg and HRP2 were associated with responses to all three serotypes in the parenteral vaccine, while I-FABP and sTfR results indicated possible strain specific immune responses to parenteral immunization.
Impact of PARP inhibitor maintenance therapy in newly diagnosed advanced epithelial ovarian cancer: A meta-analysis
Authors: Lee Banghyun , Chang Suk-Joon , Kwon Byung Su , Son Joo-Hyuk , Lim Myong Cheol , Kim Yun Hwan , Lee Shin-Wha , Choi Chel Hun , Eoh Kyung Jin , Lee Jung-Yun , Suh Dong Hoon , Kim Yong Beom 
Published: November 2023

Objectives
This meta-analysis was undertaken to systematically evaluate the effects of poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy on the survival of newly diagnosed advanced epithelial ovarian cancer (EOC) patients.

Methods/Materials
A systematic literature search revealed 3,227 studies. A subsequent selection process identified seven suitable randomized studies that assessed the survival outcomes in newly diagnosed advanced EOC patients administered PARPi (n = 1921; the PARPi group) or placebo (n = 1150; the placebo group). The survival outcomes were compared with respect to the PARPi treatment regardless of bevacizumab maintenance therapy. All adverse events ≥ grade 3 were analyzed. Review Manager Version 5.4.1 software was used for the meta-analysis.

Results
The two-year progression-free survival (PFS) was significantly better in the PARPi group than the placebo (Hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.41 to 0.68). Furthermore, patients in the PARPi group with the BRCA1/2 mutation (BRCAm), BRCA wild type, homologous-recombination deficiency (HRD), or HRD without BRCAm, but not with homologous-recombination proficiency had a significantly better two-year PFS than the patients in the placebo group. The five-year overall survival (OS) was comparable in the two groups, but patients in the PARPi group with BRCAm had a significantly better five-year OS than those in the placebo group (HR, 0.57; 95% CI, 0.44 to 0.74). In addition, the adverse event rate (≥ grade 3) was significantly higher in the PARPi group than in the placebo group (HR, 2.94; 95% CI, 1.13 to 7.63).

Conclusions
In patients with newly diagnosed advanced EOC, PARPi maintenance therapy was significantly more effective in terms of survival than no PARPi treatment. However, the risk of serious adverse events was higher for patients who received PARPi maintenance therapy.
O processo de reconstituição do acesso à documentação do Arquivo do Serviço de Beneficência da Fundação Calouste Gulbenkian
Authors: Ferreira Fernandes Rita Emília 
Published: November 2023

O Serviço de Beneficência da Fundação Calouste Gulbenkian, um dos quatro serviços fundadores, ficou responsável pela gestão dos subsídios concedidos a instituições nomeadas por Calouste Gulbenkian no seu testamento, pela coordenação dos novos pedidos de subsídios, assim como dar respostas a situações inesperadas que provocaram fragilidades numa determinada comunidade em território nacional e internacional. O arquivo desta unidade orgânica, à guarda do Arquivo da Fundação permite não só acompanhar a miríade de processos de subsídios individuais e coletivos, que ao longo das várias décadas de atividades beneficiaram várias iniciativas, como também as mudanças de direção e designação ao longo do tempo[1]. Partindo do estudo do arquivo do Serviço de Beneficência, pretendeu-se questionar o seu contexto de produção e referenciação. Este trabalho para além de se empenhar na descrição do processo de reconstituição do acesso à documentação, procura perscrutar e decifrar as lógicas, à primeira vista paradoxais, dos códigos utilizados por aquela unidade orgânica. Dedica-se ainda a uma reflexão aprofundada sobre a decalagem entre a cultura administrativa e a arquivística, que pode levar a perdas de conhecimento significativas, sendo assim perspetivadas estratégias de mitigação.
[1] Em 1971 o Serviço de Beneficência passa a denominar-se Serviço de Saúde e Proteção Social (SSPS), sendo que de 2001 a 2013 foi denominado por Serviço de Saúde e Desenvolvimento Humano (SSDH).
Landscape architectural documents in personal archives, an added challenge
Authors: Fonseca Maria João 
Published: November 2023

Incorporating architectural records into thematic archival institutions has been a common practice since the 1970s, a trend that has recently accelerated in the Portuguese context. The uniqueness of certain architectural records and collections has been an archival challenge, reflected by the several attempts to standardize their description in an ongoing process since the 1980s. While acknowledging the crucial work done by these institutions in preserving documents, there is also a tendency to focus on preserving fragments of an information system, which can have pernicious effects on understanding archives.
In an attempt to understand the composition and organization of archives in the field of landscape architecture and how they can restrict or distort archival classification and knowledge, a brief comparative analysis is conducted on the corpus of documentation of three archives under the custody of thematic institutions. For enhanced understanding, a concise overview of the discipline of landscape architecture and the roles played by its practitioners is provided. This comparative analysis attempts to demonstrate how a thematic approach, breaking organic ties, even if indelible, or underestimating lesser-known contexts or producer activities, can restrict or distort archival classification and knowledge.
The focus on Gonçalo Ribeiro Telles's archive and its ongoing organization, along with the analysis of a drawing from this archive, aims to demonstrate the need for a transition, especially in specialized or thematic institutions, from the construction of professional collections or archives to a focus on personal archives, which are organic aggregations of individuals who, during their lifetimes, also bequeathed records related to landscape architecture.
Risk of Esophageal Cancer in Achalasia: A Matched Cohort Study Using the Nationwide Veterans Affairs Achalasia Cohort
Authors: Low Eric E. , Demb Joshua , Shah Shailja C. , Liu Lin , Bustamante Ranier , Yadlapati Rena , Gupta Samir 
Published: November 2023

INTRODUCTION:
Achalasia is a postulated risk factor of esophageal cancer (EC); however, EC-associated risk in achalasia is understudied. We aimed to evaluate EC risk among individuals within the nationwide Veterans Affairs Achalasia Cohort.

METHODS:
We conducted a matched cohort study among US veterans aged 18 years or older from 1999 to 2019. Individuals with achalasia were age matched and sex matched 1:4 to individuals without achalasia. Follow-up continued from study entry until diagnosis with incident/fatal EC (primary outcome), death from non–EC-related causes, or end of the study follow-up (December 31, 2019). Association between achalasia and EC risk was examined using Cox regression models.

RESULTS:
We included 9,315 individuals in the analytic cohort (median age 55 years; 92% male): 1,863 with achalasia matched to 7,452 without achalasia. During a median 5.5 years of follow-up, 17 EC occurred (3 esophageal adenocarcinoma, 12 squamous cell carcinoma, and 2 unknown type) among individuals with achalasia, compared with 15 EC (11 esophageal adenocarcinoma, 1 squamous cell carcinoma, and 3 unknown type) among those without achalasia. EC incidence for those with achalasia was 1.4 per 1,000 person-years, and the median time from achalasia diagnosis to EC development was 3.0 years (Q1–Q3: 1.3–9.1). Individuals with achalasia had higher cumulative EC incidence at 5, 10, and 15 years of follow-up compared with individuals without achalasia, and EC risk was 5-fold higher (hazard ratio 4.6, 95% confidence interval: 2.3–9.2).

DISCUSSION:
Based on substantial EC risk, individuals with achalasia may benefit from a high index of suspicion and endoscopic surveillance for EC.
How to Improve on the Gray’s Index for Accounting Conservatism
Authors: Biondi Yuri 
Published: November 2023

Abstract
The Gray’s index has been used to compare accounting variables such as earnings in a sample of financial accounting figures since its introduction by Gray (Gray, S. J. 1980. “The Impact of International Accounting Differences from a Security-Analysis Perspective: Some European Evidence.” Journal of Accounting Research 18 (1): 64–76), in view to indicate the relative degree of accounting conservatism between sets of accounting standards. This note aims to improve on this index especially when variables under investigation can be negative. In the latter case, proportionality between the two variables may be hidden by its application. We suggest therefore some amendments to better show this proportionality and improve on statistical comparison of accounting figures generated by alternative sets of accounting standards.
Digitalisierung, soziale Klasse und Corona
Authors: Niehoff Steffen , Holst Hajo 
Published: November 2023

Zusammenfassung
Als Beitrag zur Forschung über Ungleichheiten in der Digitalisierung von Arbeit beschäftigt sich der Artikel mit dem pandemiebedingten Homeoffice. Mit Hilfe des Klassenansatzes von Daniel Oesch wird untersucht, welchen Einfluss die berufliche Position auf die Organisation des digital ermöglichten ortsflexiblen Arbeitens in der Corona-Krise hat. Anhand von logistischen Regressionen wird gezeigt, dass die Klassenlage nicht nur wesentlich den Zugang zum Homeoffice und das Ausmaß des Arbeitens von zu Hause bestimmt. Die berufliche Position hat auch starken Einfluss auf die arbeitspolitische Qualität des Homeoffice, gemessen in den drei Dimensionen Heimarbeitsplatz, Steuerung und Vernetzung. Auffällig ist, dass die unteren Klassen beim Thema Homeoffice mehrfach unterprivilegiert sind: Beschäftigte in Ausbildungsberufen und Anlerntätigkeiten haben in der Pandemie deutlich geringere Chancen, von zu Hause zu arbeiten, und wenn sie doch die Gelegenheit haben, verbringen sie weniger Zeit im Homeoffice und tragen größere Risiken, unter schlechten arbeitspolitischen Bedingungen von zu Hause arbeiten zu müssen. Privilegiert sind hingegen die technischen Expert*innen, akademische Berufe mit technischem Hintergrund. Sie arbeiten häufiger und länger im Homeoffice als alle anderen Klassen und finden dort die besten arbeitspolitischen Bedingungen vor. Empirisch basiert der Beitrag auf qualitativen Interviews (n = 35) und einem Survey, an dem sich im Frühjahr 2021 und 2022 über 10.000 abhängig Beschäftigte beteiligten.
Optimization of railway entry and exit transition curves
Authors: Woznica Piotr 
Published: November 2023

Abstract
This work concerns the optimization of the shapes of railway entry and exit transition curves (TCs). In this work, mathematical optimization and simulation methods are used. The applied computer simulation concerned the behaviour of the dynamical model of a two-axle rail vehicle. A polynomial of degree n, where n = 9 and 11, was adopted as a TC in the performed analyses. Three radii of the circular arc were used in the work – 600, 1,200, and 2,000 m. The aim of the research was to find optimum TC shapes taking into account the adopted criteria and to compare them with each other.
Experimental study of the phase relations of the Fe–Pt–Ho ternary system at 500 °C
Authors: Peng Ling , Zhou YiFan , Xu Bo , Gao XinQiang , Gu Zheng-Fei , Xu Cheng-Fu 
Published: November 2023

Abstract
The phase relations of the Fe–Pt–Ho ternary system at 500 °C have been studied by using X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy techniques. The Ho3Pt4 phase is stable at 500 °C, and the introduction of Fe does not cause the Ho3Pt4 phase to be decomposed into the two neighbouring phases HoPt and HoPt2. The single phase ranges of α-Fe, Fe3Pt, FePt, FePt3 and Pt in Fe–Pt binary system are from 0 to 10 at.% Pt, 14 to 32 at.% Pt, 33 to 63 at.% Pt, 66 to 78 at.% Pt, and 82 to 100 at.% Pt, respectively. The highest solid solubility of Ho in the α-Fe, Fe3Pt, FePt, FePt3 and (Pt, Fe) phases is less than 1.5 at.% Ho, 2 at.% Ho, 2 at.% Ho, 1.5 at.% Ho and 1.5 at.% Ho, respectively. The isothermal section at 500 °C of the Fe–Pt–Ho ternary alloy phase diagram has been constructed, which consists of 19 single-phase regions, 35 two-phase regions and 17 three-phase regions. No new ternary compounds were found.
Analysis of mechanical and water absorption properties of hybrid composites reinforced with micron-size bamboo fibers and ceramic particles
Authors: Tahir Danish , Abdul Karim Muhammad Ramzan , Hu Hong 
Published: November 2023

Abstract
Bamboo and its hybrid composites were made using the hand lay-up method to evaluate the change in mechanical and physical properties that occurred through filler addition. Density measurements and tensile test results showed an increment in values when a certain percentage of silicon carbide (SiC) was added. As the SiC percentage grows from 0 to 6 %, the density of the hybrid composite increases from 1.15 to 1.36 gm/cc whereas tensile strength increases from 37 MPa to 42 MPa when 4 wt% SiC is added in 20 wt% of the bamboo composite. The scanning electron microscopy (SEM) analysis of tensile fractured samples further supported the improvement in tensile characteristics. To examine the impact and hardness characteristics, composites were subjected to the Charpy impact test and hardness test. 4 wt% of SiC addition in 20 wt% of the bamboo composite decreased the impact strength from 28.79 to 27.43 (×10−3 kJ/m2) and increased the hardness from 44 to 55 Hv. The composites’ water absorption behavior demonstrated that the addition of filler lifts the composite’s resistance to absorbing water, preserving the composites’ dimensional firmness and mechanical qualities.
Spin(8,C)-Higgs pairs over a compact Riemann surface
Authors: Antón-Sancho Álvaro 
Published: November 2023

Abstract
Let

X

X

be a compact Riemann surface of genus

g
≥
2

g\ge 2

,

G

G

be a semisimple complex Lie group and

ρ
:
G
→
GL

(

V

)

\rho :G\to {\rm{GL}}\left(V)

be a complex representation of

G

G

. Given a principal

G

G

-bundle

E

E

over

X

X

, a vector bundle

E

(

V

)

E\left(V)

whose typical fiber is a copy of

V

V

is induced. A

(

G
,
ρ

)

\left(G,\rho )

-Higgs pair is a pair

(

E
,
φ

)

\left(E,\varphi )

, where

E

E

is a principal

G

G

-bundle over

X

X

and

φ

\varphi

is a holomorphic global section of

E

(

V

)

⊗
L

E\left(V)\otimes L

,

L

L

being a fixed line bundle over

X

X

. In this work, Higgs pairs of this type are considered for

G
=
Spin

(

8
,
C

)

G={\rm{Spin}}\left(8,{\mathbb{C}})

and the three irreducible eight-dimensional complex representations which

Spin

(

8
,
C

)

{\rm{Spin}}\left(8,{\mathbb{C}})

admits. In particular, the reduced notions of stability, semistability, and polystability for these specific Higgs pairs are given, and it is proved that the corresponding moduli spaces are isomorphic, and a precise expression for the stable and not simple Higgs pairs associated with one of the three announced representations of

Spin

(

8
,
C

)

{\rm{Spin}}\left(8,{\mathbb{C}})

is described.