bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desafios da atuação fisioterapêutica com idosos na atenção domiciliar pela estratégia de saúde da família no SUS: Revisão integrativa
Authors: Santos Sissiane Viana dos , Ferro Thauan Narciso de Lima , Alves Ahyas Sydcley Santos 
Published: January 2024

Este estudo objetivou investigar os desafios da atuação fisioterapêutica com idosos na Atenção Domiciliar pela Estratégia de Saúde da Família no SUS, através de revisão integrativa de literatura. As fontes de dados utilizadas foram bases eletrônicas e busca na lista de referência dos artigos. Os artigos foram buscados nas bases de dados eletrônicas: BVS, Scielo, PubMed, Lilacs e PEDro, utilizando as estratégias busca de combinações dos descritores a seguir selecionados da base Descritores em Ciências da Saúde (DECS): Fisioterapia, Idoso, Assistência domiciliar, Saúde da família e Sistema único de saúde. Objetivou-se, na pesquisa dos artigos, incluir publicações científicas que abordavam o objetivo da pesquisa, que estivesse com texto completo e disponível, contemplando pelo menos um dos descritores escolhidos, publicados de 2018 a 2023, em português, inglês e/ou espanhol. Após aplicação dos critérios e leitura dos achados foram selecionados 8 artigos para compor a revisão. Observou-se que a pode a atuação da fisioterapia domiciliar para idosos na Estratégia de Saúde da Família (ESF) pode ser de grande importância, apresentando uma gama de possibilidades de condutas, protocolos e parâmetros. Constatou-se que neste contexto enfrenta-se uma série de desafios complexos. Para avançar no entendimento destes desafios, são necessárias pesquisas que integrem metodologias variadas, como estudos longitudinais que acompanhem o impacto das intervenções ao longo do tempo, análises qualitativas para compreender as perspectivas dos idosos, cuidadores e profissionais de saúde envolvidos, e estudos de caso que identifiquem boas práticas e desafios enfrentados em contextos específicos.
Fenomena Las Gesek (Friction Welding) Dengan Variasi Waktu Gesek Pada Material AISI 1040 Dengan Kuningan
Authors: Sofwan Ibnu , Sugiyarto  , Erwanto Erwanto 
Published: January 2024

Friction welding is one of the metal joining methods, by utilizing the heat generated from the physical contact of two metals in the form of friction that occurs continuously on the two metals to produce a welding joint. This research aims to find out what phenomena occur in the connection between AISI 1040 and Brass. The materials used are AISI 1040 solid cylinder with a diameter of 16 mm and brass solid cylinder with a diameter of 16 mm. This research uses experimental method. The friction time used is 6 minutes, 7 minutes, and 8 minutes with a variation of pressing distance of 3 mm, 4 mm, 5 mm with a rotating speed of 1000 rpm. The free heat process of 200 ℃ was carried out on AISI 1040 before the welding process. From the time variation and pressing distance variation that has been carried out in this study, the results obtained from the two materials do not occur. There are several phenomena seen after the welding process such as the occurrence of plastic deformation in brass and the formation of a brass thermoplastic layer attached to the surface of AISI 1040, in the time variation of 6 minutes and 7 minutes the brass thermoplastic attached to AISI 1040 is small and thin, while in the time variation of 8 minutes the brass thermoplastic layer attached to AISI is quite a lot and thick but no connection has occurred. This friction welding method is likely to connect the AISI 1040 material with brass by increasing the friction time performed.
HEALTH LAW IMPLEMENTATION REALIZES GENDER EQUALITY AND WOMEN'S EMPOWERMENT
Authors: Siregar Rospita , Hendri Jayadi  
Published: January 2024

The millennium development program (MDGs) in quality health services, including women's reproductive health, is not evenly distributed, due to poor infrastructure and the unequal quality of health services between provinces. It is hoped that Indonesian Health has succeeded in achieving most of Indonesia's MDGs targets, namely 49 of the 67 MDGs indicators can be improved. In normative juridical research, law is conceptualized as norms or rules that apply in society. Using a statutory approach and a conceptual approach in health law. There is a guarantee of a sense of security in accordance with Article 28G Paragraph (1) of the 1945 Constitution, thereby providing women's rights in accordance with the mandate given by the state and guaranteeing rights without discrimination and gender differences. There is the Convention on the Elimination of All Forms of Discrimination against Women, which emphasizes that women's human rights are respected, then women's reproductive health rights have also been formulated by the International Planned Parenthood Federation (IPPF) since 1996, namely the right to equality and freedom from all forms of discrimination. In the end, support for women's empowerment must involve many parties from politics, PUG institutions, Human Resources, Budget, Gender Analysis Tools, and Community Participation.
Keywords: gender equality, health law, reproductive health rights
Why do lactic acid bacteria thrive in chain elongation microbiomes?
Authors: Ulčar Barbara , Regueira Alberte , Podojsteršek Maja , Boon Nico , Ganigué Ramon 
Published: January 2024

Efficient waste management is necessary to transition towards a more sustainable society. An emerging trend is to use mixed culture biotechnology to produce chemicals from organic waste. Insights into the metabolic interactions between community members and their growth characterization are needed to mediate knowledge-driven bioprocess development and optimization. Here, a granular sludge bioprocess for the production of caproic acid through sugar-based chain elongation metabolism was established. Lactic acid and chain-elongating bacteria were identified as the two main functional guilds in the granular community. The growth features of the main community representatives (isolate Limosilactobacillus musocae G03 for lactic acid bacteria and type strain Caproiciproducens lactatifermentans for chain-elongating bacteria) were characterized. The measured growth rates of lactic acid bacteria (0.051 ± 0.005 h−1) were two times higher than those of chain-elongating bacteria (0.026 ± 0.004 h−1), while the biomass yields of lactic acid bacteria (0.120 ± 0.005 g biomass/g glucose) were two times lower than that of chain-elongating bacteria (0.239 ± 0.007 g biomass/g glucose). This points towards differential growth strategies, with lactic acid bacteria resembling that of a r-strategist and chain-elongating bacteria resembling that of a K-strategist. Furthermore, the half-saturation constant of glucose for L. mucosae was determined to be 0.35 ± 0.05 g/L of glucose. A linear trend of caproic acid inhibition on the growth of L. mucosae was observed, and the growth inhibitory caproic acid concentration was predicted to be 13.6 ± 0.5 g/L, which is the highest reported so far. The pre-adjustment of L. mucosae to 4 g/L of caproic acid did not improve the overall resistance to it, but did restore the growth rates at low caproic acid concentrations (1–4 g/L) to the baseline values (i.e., growth rate at 0 g/L of caproic acid). High resistance to caproic acid enables lactic acid bacteria to persist and thrive in the systems intended for caproic acid production. Here, insights into the growth of two main functional guilds of sugar-based chain elongation systems are provided which allows for a better understanding of their interactions and promotes future bioprocess design and optimization.
Characterization of Klebsiella pneumoniae carrying the blaNDM-1 gene in IncX3 plasmids and the rare In1765 in an IncFIB-IncHI1B plasmid
Authors: Ma Liman , Qu Ying , Wang Wenji , Wang Dongguo 
Published: January 2024

BackgroundToday, the blaNDM gene is widely distributed on several plasmids from a variety of Gram-negative bacteria, primarily in transposons and gene cassettes within their multidrug-resistant (MDR) regions. This has led to the global dissemination of the blaNDM gene.MethodsThe determination of class A beta-lactamase, class B and D carbapenemases was performed according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Antimicrobial susceptibility testing was performed using both the BioMerieux VITEK2 system and antibiotic paper diffusion methods. Plasmid transfer was then evaluated by conjugation experiments and plasmid electroporation assays. To comprehensively analyze the complete genome of K. pneumoniae strain F11 and to investigate the presence of mobile genetic elements associated with antibiotic resistance and virulence genes, Nanopore and Illumina sequencing platforms were used, and bioinformatics methods were applied to analyze the obtained data.ResultsOur findings revealed that K. pneumoniae strain F11 carried class A beta-lactamase and classes B+D carbapenemases, and exhibited resistance to commonly used antibiotics, particularly tigecycline and ceftazidime/avibactam, due to the presence of relevant resistance genes. Plasmid transfer assays demonstrated successful recovery of plasmids pA_F11 and pB_F11, with average conjugation frequencies of 2.91×10-4 and 1.56×10-4, respectively. However, plasmids pC_F11 and pD_F11 failed in both conjugation and electroporation experiments. The MDR region of plasmid pA_F11 contained rare In1765, TnAs2, and TnAs3 elements. The MDR2 region of plasmid pB_F11 functioned as a mobile genetic “island” and lacked the blaNDM-1 gene, serving as a “bridge” connecting the early composite structure of bleMBL and blaNDM-1 to the recent composite structure. Additionally, the MDR1 region of plasmid pB_F11 comprised In27, TnAs1, TnAs3, and Tn2; and plasmid pC_F11 harbored the recent composite structure of bleMBL and blaNDM-1 within Tn3000 which partially contained partial Tn125.ConclusionThis study demonstrated that complex combinations of transposons and integron overlaps, along with the synergistic effects of different drug resistance and virulence genes, led to a lack of effective therapeutic agents for strain F11, therefore its dissemination and prevalence should be strictly controlled.
Endogenous retroviruses Suppressyn and Syncytin-2 as innovative prognostic biomarkers in Acute Myeloid Leukemia
Authors: Shen Jiaxin , Wen Xiaofen , Xing Xueyang , Fozza Claudio , Sechi Leonardo Antonio 
Published: January 2024

IntroductionEmerging evidence has proven that human endogenous retroviruses (HERVs) play a critical role in the pathogenesis of Acute Myeloid Leukemia (AML), whereas the specific HERVs influencing the prognosis of AML patients have yet to be fully understood.MethodsIn this study, a systematic exploration was achieved to identify potential prognostic HERVs for AML, sourced from TCGA and GTEx database. Differential analysis and functional enrichment studies were conducted using GO, KEGG, GSEA, and GSVA. The ESTIMATE algorithm was applied to explore the immune infiltration of HERVs in AML. A prognostic risk-score model was evaluated with predicted yearly accuracy using ROC analysis.ResultsTwo HERVs Suppressyn and Syncytin-2, were identified as promising prognostic biomarkers, with high discrimination ability based on ROC analysis between AML and healthy cohorts from TCGA. Their expression was notably higher in AML patients compared to those in healthy individuals but correlates with favorable clinical outcomes in sub-groups such as white race, lower WBC counts, favorable and intermediate risks, and NPM1 or IDH1 mutation. Suppressyn and Syncytin-2 participated in immune-related pathways and exhibited correlations with multiple immune infiltration cells, such as T cells, mast cells, and tumor-associated macrophages. Finally, we developed a prognostic risk-scoring model combining Suppressyn and Syncytin-2, where a high risk-score is associated with better prognosis.DiscussionCollectively, our findings revealed that Suppressyn and Syncytin-2 may act as valuable diagnostic and prognostic biomarkers for individuals with AML, while highlighting links between HERV activation, immunogenicity, and future therapeutic targets.
Stratigraphic-sedimentary evolution of a mixed siliciclastic-carbonate system in the Huizhou Sag of the Pearl River Mouth Basin, Northern South China Sea
Authors: Chen Weitao , Liu Jun , Peng Guangrong , Wei Zhe , Jia Peimeng , Yao Jiali , Wang Zhina , Zhuo Haiteng 
Published: January 2024

Mixed siliciclastic-carbonate systems are regulated interactively by factors such as siliciclastic sediment supply, carbonate production, sea-level change, tectonism, and climate conditions. These systems record vital information that aids in understanding ancient environments. This study used a merged 3D seismic volume, in conjunction with over 100 industrial wells, to systematically investigate the stratigraphic-sedimentary evolution of such a system within the Huizhou Sag of the Pearl River Mouth Basin, located on the northern continental shelf of the South China Sea. In total, six major sequence boundaries were identified for the Zhujiang Formation within the area, thus subdividing the interval into five typical third-order depositional sequences. Each of these sequences can be divided into a transgressive and a highstand systems tract. Lowstand or falling stage systems tracts were also recognized, the deposition of which was potentially in response to the uplifting process of the Dongsha Rise. During the deposition of the Zhujiang Formation, the Huizhou Sag may have undergone a sequential evolutionary history from delta-shore, to delta-shore-tidal-lagoon, to delta-shore-carbonate, and finally to delta-shore-shallow marine systems. This evolution responded to a varying degree of mixing processes, which was mainly regulated by siliciclastic sediment supply, confined paleomorphology, and local oceanic currents. Furthermore, the deposition of the Zhujiang Formation in the Huizhou Area was time-equivalent with the spreading process after the ridge jump of the South China Sea (23–16.5 Ma), providing valuable insights into sea-level fluctuations, provenance changes, and tectonic evolution. Our results may also shed light on the evaluation of lithologic traps and hydrocarbon sweet spots within mixed siliciclastic-carbonate systems.
A cross-sectional analysis of the relationship between ischemic stroke and uric acid in young people in highland areas
Authors: Yang Yifan , Gao Li , Shen Fuwei , Miao Jiaodan , Liu Hua 
Published: January 2024

ObjectiveTo investigate the relationship between serum uric acid (SUA) levels and ischemic stroke in young patients in the Ganzi Tibetan plateau area.MethodsA cross-sectional survey was undertaken from January 2020 to June 2023 involving young patients (age: 15–45 years) diagnosed with ischemic stroke. The survey was conducted at the Department of Internal Medicine of the People’s Hospital of Derong County, Ganzi Prefecture. The participants underwent a comprehensive assessment, including questionnaire surveys, physical examinations, laboratory tests, and head computed tomography (CT) examinations. Based on the tertiles of serum uric acid (SUA) levels, the patients were stratified into three groups. Furthermore, stroke severity was classified into mild (1–4 points), moderate (5–15 points), and severe (&gt;15 points) categories using the National Institute of Health Stroke Scale.ResultsThe severe stroke group exhibited higher levels of age, glucose, systolic blood pressure, serum triglyceride, low-density lipoprotein cholesterol, and serum uric acid (SUA) compared to the mild stroke group (P &lt; 0.05). Furthermore, the likelihood of male sex, advanced age, smoking, and a family history of stroke, diabetes mellitus, and heart disease were significantly elevated in the severe stroke group compared to the moderate stroke group (P &lt; 0.05). Multivariate logistic regression analysis conducted on young adults residing in highland areas revealed a significant association between SUA levels and the risk of stroke.ConclusionElevated SUA levels serve as a distinct risk factor for the development of a major stroke in young patients in highland areas. At SUA levels of 320.56 mol/L, the risk of a moderate-to-severe stroke is noticeably elevated.
Potential disease biomarkers for diabetic retinopathy identified through Mendelian randomization analysis
Authors: Zou Xuyan , Ye Suna , Tan Yao 
Published: January 2024

BackgroundDiabetic retinopathy (DR), a leading cause of vision loss, has limited options for effective prevention and treatment. This study aims to utilize genomics and proteomics data to identify potential drug targets for DR.MethodsWe utilized plasma protein quantitative trait loci data from the Atherosclerosis Risk in Communities Study and the Icelandic Decoding Genetics Study for discovery and replication, respectively. Genetic associations with DR, including its subtypes, were derived from the FinnGen study. Mendelian Randomization (MR) analysis estimated associations between protein levels and DR risk, complemented by colocalization analysis to examine shared causal variants.ResultsOur MR analysis identified significant associations of specific plasma proteins with DR and proliferative DR (PDR). Elevated genetically predicted levels of WARS (OR = 1.16; 95% CI = 0.095-0.208, FDR = 1.31×10-4) and SIRPG (OR = 1.15; 95% CI = 0.071-0.201, FDR = 1.46×10-2) were associated with higher DR risk, while increased levels of ALDOC (OR = 1.56; 95% CI = 0.246-0.637, FDR = 5.48×10-3) and SIRPG (OR = 1.15; 95% CI = 0.068-0.208, FDR = 4.73×10-2) were associated with higher PDR risk. These findings were corroborated by strong colocalization evidence.ConclusionsOur study highlights WARS, SIRPG, and ALDOC as significant proteins associated with DR and PDR, providing a basis for further exploration in drug development. Additional studies are needed to validate these proteins as disease biomarkers across diverse populations.
Modeling of vehicle carbon emissions on horizontal curve road sections
Authors: Dong Yaping , Li Tong , Xu Jinliang 
Published: January 2024

The high carbon emissions of vehicles traveling on horizontal curve road sections cannot be ignored. Facing the difficulty of accurately quantifying the carbon emission of driving on horizontal curves and the unknown causes of high carbon emission, this study proposes to construct a carbon emission prediction model applicable to road sections with different planar geometries. The direct and indirect effects of horizontal curve alignment on vehicle carbon emissions are represented in the model in terms of travel stabilization and speed changes, respectively. A lateral force coefficient parameter was introduced into the model to integrate the carbon emission quantification problem for different planar geometry sections. Meanwhile, field tests were conducted to assess the reliability of the model and the research findings. The model reveals that the geometric parameters of horizontal curves that affect carbon emissions are the radius of the circular curve, the superelevation, and the length of the gentle curve. The root causes of high carbon emissions on horizontal curve road sections are curve driving resistance and speed fluctuations. Under the free-flow driving condition of the highway, the maximum curve radius affecting the carbon emissions of passenger cars and trucks is 400 m and 550 m, respectively. The research results can realize the carbon emission quantification of vehicles on the road sections with different plane geometries. Also, it is helpful to control the high carbon emission of vehicles traveling on horizontal curve road sections.
Plant communities and potential phytoremediation species for resource utilization of abandoned drilling mud
Authors: Wang Shuzhuan , Hao Mingde 
Published: January 2024

Oil and gas development produces a large amount of abandoned drilling mud, which may be a source of pollution but may also be a potential resource. A quadrat sampling method was used in the Changqing Oilfield to investigate the plant community characteristics inside and outside abandoned drilling mud pits at different completion times. The importance value of plant showed that the natural succession of plant communities in the abandoned drilling mud pool could be divided into three stages: (1) 4–8 years after the completion of the well, Leymus secalinus, Calamagrostis epigeios with the importance values of more than 100, were dominant species in the initial construction stage; (2) 9–13 years after the succession, the intense competition stage of the plant community, although the importance value of plant inside the mud pit had decreased, it was still higher than the importance value of plant outside the mud pool. The importance values of L. secalinus and Artemisia scoparia outside the mud pool were 62.5 and 52.5, while those in the mud pool were 95 and 75, respectively; (3) 23–28 years after the succession, the gradual stabilization stage of the plant community, the importance value of plant was lower than that in the mud pool. Leymus secalinus, C. epigeios and A. scoparia could be used for phytoremediation of abandoned drilling soil for their higher importance values. Changes of Shannon–Wiener index, Pielou index, Community ecological dominance and vegetation biomass showed that the mud pit was suitable for the recovery and growth of the dominant species, improved the diversity of plant communities inside the mud pit compared with the stable plant community outside the mud pit. Abandoned drilling mud increased the content of nitrogen, potassium and trace elements in plants. While the variation coefficient of heavy metal content in plants inside and outside the mud pit was large, but the content of heavy metals in plants was within the normal range. Abandoned drilling mud has the potential for resource utilization on the premise of ensuring soil quality and safety. This study provides information on the comprehensive treatment, resource utilization, disposal economics and environmental safety of abandoned drilling mud.