bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Vitamin D Deficiency and Changes in Cognitive
Functions in Chinese Older Adults: A Prospective Cohort Study
Authors: Li Tongtong , Chen Chong , Yuan Jing , Zhang Keming , Zhang Meilin , Zhao Huichao , Wu Xiaomin , Zhu Liping , Huang Guowei , Ma Fei 
Published: November 2023

Background::
Along with the problem of population aging, the prevalence of dementia is gradually increasing. Associations between vitamin D deficiency (VDD) and cognitive functions remains controversial.

Objectives::
We aimed to determine the relationship between VDD and changes in cognitive performance in community-dwelling older adults.

Methods::
In this longitudinal cohort study, Chinese participants aged ≥65 years were enrolled in March 2016. The serum level of 25-hydroxy-vitamin D was analyzed by liquid-chromatography-tandem-mass-spectrometry at baseline. VDD was defined as less than 20ng/mL. All participants accomplished a health status questionnaire. Cognitive functions were evaluated by Wechsler Adult Intelligence Scale-Revised in China at baseline and each visit. The linear mixed-effects model was utilized to examine the association between baseline VDD and changes in cognitive functions.

Results::
In total, 866 participants were included in our study, with a mean duration of 3 years. VDD was markedly associated with lower full intelligence quotient (FIQ) (β: -3.355, 95% confidence interval [CI]:-4.165,-2.545), verbal intelligence quotient (VIQ) (β: -3.420, 95%CI: -4.193,-2.647), performance intelligence quotient (PIQ) (β: -2.610, 95%CI: -3.683,-1.537), comprehension (β: -0.630, 95%CI: -1.022,-0.238), information (β: -0.354, 95%CI: -0.699,-0.008), arithmetic (β: -1.065, 95%CI: -1.228,-0.902), digit span (β: -0.370, 95%CI: -0.547,-0.192), vocabulary (β: -0.789, 95%CI: -1.083,-0.493), picture completion (β: -0.391, 95%CI: -0.761,-0.022), block design (β: -0.412, 95%CI: -0.697,-0.127), picture arrangement (β: -0.542, 95%CI: -0.909,-0.174) and object assembly (β: -0.492, 95%CI: -0.818,-0.165) than those with adequacy.

Conclusion::
A higher frequency of VDD was associated with lower scores of FIQ, VIQ, PIQ and
subtests on memory and executive function. Future randomized controlled trials are warranted to
further verify the conclusions
The Role of Vasodilator-stimulated Phosphoproteins in the Development
of Malignant Tumors
Authors: Gui Jiandong , Zhou Hangsheng , Wan Hongyuan , Yang Dongjie , Liu Qing , Zhu Lijie , Mi Yuanyuan 
Published: November 2023

Abstract:
Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein that includes
three structural domains: Enabled/VASP homolog1 (EVH1), EVH2, and proline-rich (PRR). VASP
plays an important role in various cellular behaviors related to cytoskeletal regulation. More importantly,
VASP plays a key role in the progression of several malignant tumors and is associated
with malignant cell proliferation, invasion, and metastasis. Here, we have summarized current studies
on the impact of VASP on the development of several malignant tumors and their mechanisms.
This study provides a new theoretical basis for clinical molecular diagnosis and molecular targeted
therapy.
The Relationship between COVID-19 Severity and Plasma Levels of
Vascular Endothelial Growth Factor (VEGF)
Authors: Fekri Mitra Samareh , Barfzade Elham , Shafahi Ahmad , Farokhnia Mehrdad , Robati Fatemeh Karami , Movahedinia Sajjadeh , Dabiri Shariar 
Published: November 2023

Background:
This study aimed to assess the relationship between COVID-19 severity
and the plasma levels of vascular endothelial growth factor.

Methods:
This cross-sectional study was conducted on 86 patients with COVID-19. A 5 ml venous
blood sample was taken on the first day of hospitalization. VEGF was measured with the
ELISA method using the Hangzhou East biopharm VEGF ELIZA Kit.

Results:
Although plasma VEGF levels were higher in the severe group than in the non-severe
group, no significant relationship was found between the plasma level of VEGF and
COVID-19 severity, which might be due to the small sample size. VEGF may be a valuable scientific
marker, but in this study, it was not as useful as other markers in identifying COVID-19
severity. In addition, there was a direct and significant relationship between COVID-19 severity
and the inflammatory markers LDH, neutrophil/lymph, and CRP. Therefore, measurement of inflammatory
markers can assist in the early identification and prediction of severity and disease
progression in COVID-19.

Conclusion:
Although plasma VEGF levels were higher in the severe group than in the non-severe
group, no significant relationship was found between the plasma level of VEGF and
COVID-19 severity, which might be due to the small sample size. VEGF may be a valuable scientific
marker, but in this study, it was not as useful as other markers in identifying COVID-19
severity. In addition, there was a direct and significant relationship between COVID-19 severity
and the inflammatory markers LDH, neutrophil/lymph, and CRP. Therefore, measurement of inflammatory
markers can assist in the early identification and prediction of severity and disease
progression in COVID-19.
A Comprehensive Review on Molecular Mechanism Involved in Arsenic Trioxide Mediated Cerebral Neurodegenerative and Infectious Diseases
Authors: Negi Vaishali , Singh Prabhat , Singh Lubhan , Pandey Rupesh Kumar , Kumar Sokindra 
Published: November 2023

Abstract:
Arsenic is an environmental toxicant and its toxicity is a global health problem affecting
millions of people. Arsenic exposure occurs from natural geological sources leaching into aquifers,
contaminating drinking water and may also occur from mining and other industrial processes. Both
cancerous, noncancerous and immunological complications are possible after arsenic exposure. The
many other target organs like lungs, thymus, spleen, liver, heart, kidney, and brain. Arsenic-mediated
neuro, as well as immunotoxicity, is the main concern of this review. Long-term arsenic exposure can
lead to various neurological dysfunctions, which may cause neurobehavioral defects and biochemical
impairment in the brain, this might negatively affect one's quality of life in later stages. Arsenic also
alters the levels of various neurotransmitters such as serotonin, dopamine and norepinephrine in the
brain which produces neurotoxic effects and immunological deficiency. So, it is crucial to understand
the neurotoxic mechanism of arsenic trioxide-mediated cerebro neurodegenerative and immunerelated
alterations. One of the major mechanisms by which it exerts its toxic effect is through an impairment
of cellular respiration by inhibition of various mitochondrial enzymes, and the uncoupling
of oxidative phosphorylation. This review focuses on the various toxic mechanisms responsible for
arsenic-mediated neurobehavioral and immune-related changes. Therefore, this review provides a
critical analysis of mitochondrial dysfunctions, oxidative stress, glutamate excitatory, inflammatory
and apoptosis-related mechanistic aspects in arsenic-mediated immunotoxicity, neurotoxicity, and
neurodegenerative changes.
Innovative Nanomaterials for Targeting Hypoxia to Improve
Treatment for Triple-negative Breast Cancer
Authors: Ray Suman  Kumar , Mukherjee Sukhes 
Published: November 2023

Abstract:
Triple-negative breast cancer (TNBC) is an aggressive breast cancer with a
high rate of metastases, a short overall survival time, and a poor response to targeted therapy.
Improving tumor hypoxia by lowering the oxygen consumption rate of breast tumor
cells is a powerful strategy. A viable way to address this issue is to improve therapeutic
efficacy by improving the effectiveness of radiation and overcoming drug resistance in
TNBC treatment by controlling hypoxia in the tumor microenvironment. The failure of
radiation and chemotherapy in TNBC is frequently caused by hypoxia. In TNBC therapy,
novel nanomaterials are used for oxygen delivery or generation to affect the tumor microenvironment
to improve the effects of ionizing radiation using nanoplatforms. One of the
growing fields is novel nano-based drug delivery devices for hypoxic regions and hypoxia-
inducible factor-1 (HIF1) targeted therapeutics. Biocompatible nanoparticles may be
used in the treatment of TNBC patients in the clinic. Because of the rising market and
competition, intellectual property rights (IPR), patents, and tactics may be critically considered.
To better comprehend the current state of IPR and patents in cancer nanotechnology,
this overview examines recent advances and sophisticated protection measures in
this area.
Water Extract of Onion Catalyst: A Sustainable Approach for the Synthesis
of 4-Substituted 1,5-Benzodiazepine Derivatives via an In Situ Generated
Enaminones
Authors: Selvaraj Loganathan , Eswaran Rajendran , Natesan Vennila Kailasam , Muthu Seenivasa Perumal 
Published: November 2023

Background:
A simple, convenient and environmentally benign green protocol has been
developed for the one-pot synthesis of 4-substituted-1,5-benzodiazepines through three-component
reaction of 1,2-diamine, 1,3-cyclic diketone with an aldehyde catalyzed by water extract of onion.
The reaction conditions were optimized and the scope of the reaction was extended to various 1,2-
diamines, 1,3-cyclic diketones and aldehydes. The main advantages of this method are good to
excellent yields, easy workup, simple experimental procedure, and an ability to tolerate a variety of
functional groups which gives cost-effective as well as green rewards. The structure of compound
5f was confirmed by single crystal X-ray analysis.

Objective:
A methodology developed for the synthesizing of 4-substituted 1,5-Benzodiazepine derivatives
via enaminones intermediates using 1,2-diamine, 1,3-cyclic diketone and aldehyde in environmentally
friendly ethanol as medium.

Methods:
As a more environmentally friendly catalyst for producing products containing benzodiazepines
using aqueous extract of onion. The devised method was proven reliable, non-toxic and
greener solvent with quick work-up to produce the intended product.

Results:
Here, using a one-pot, three-component reaction with a dimedone, 1,2-diamine and range
of aldehyde while using water extract of onion as a catalyst. The acquired experimental results
showed that the employed synthesis methodology is a straightforward procedure that offers various
benefits, including sustainability, easy separtion from the reaction medium.

Conclusion:
We have developed a sustainble approach for synthesizing benzodiazepine from radily
available precursors under mild reaction conditions.
Feasibility and Usability of the Job Adjustment Mobile App for Pregnant Women: Longitudinal Observational Study
Authors: Wada Aya , Nakamura Yasuka , Kawajiri Maiko , Takeishi Yoko , Yoshida Mikako , Yoshizawa Toyoko 
Published: November 2023

Background
Working pregnant women often need to adjust their physically demanding jobs for a healthy pregnancy. However, uncertainty about the extent of these adjustments can hinder their effectiveness. To address this, we developed the Job Adjustment mobile app, which allows users to input job and health details to generate a variety of personalized action plans. As this is the first version of the app, assessing its feasibility and usability is crucial.

Objective
This study aims to verify the feasibility and usability of the Job Adjustment mobile app.

Methods
A longitudinal observational study was conducted on pregnant Japanese women who were allowed to use the app anytime from 12 to 34 weeks of gestation; they received reminder emails every 2 weeks encouraging app use. A questionnaire was administered before app use and at 20 and 32 weeks of gestation. Feasibility was evaluated across 4 domains: implementation, demand, acceptability, and adverse events. Implementation was evaluated based on 3 parameters: dropout rate, initial reminder email receipt rate, and adherence rate (measured as pregnant women who used the app at intervals of 2.5 weeks or less). Demand was measured by intervals between use and intervals between log-in, and participants answered 15 questions to assess acceptability. Adverse events were assessed by analyzing the degree of anxiety related to work. Demographic data were analyzed to determine any statistically significant differences in intervals between uses. Usability was evaluated using the System Usability Scale.

Results
The analysis included 66 pregnant women, and 61% (n=40) of them were multipara. The dropout rate, adherence rate, and initial reminder email receipt rate were 18% (13/71), 44% (29/66), and 79% (52/66) respectively. The median intervals between use and intervals between log-in were 2.94 (IQR 2.00-5.13) weeks and 2.28 (IQR 1.81-4.00) weeks, respectively. Overall, 60% (35/58) to 90% (52/58) of the participants responded positively to all 15 questions assessing acceptability, and no anxiety regarding work was recorded. The mean System Usability Scale score was 66.1 points. Multipara women had significantly longer intervals between app use compared to primipara women (P=.01).

Conclusions
The results demonstrated acceptable levels of feasibility and usability of the app. However, the low adherence rates, especially among multipara women, suggest the need for modifications to reduce the time burden of the app. Further research should explore more effective and acceptable intervals between use and timing, involving a larger sample and accounting for diverse characteristics of pregnant women.

Trial Registration
UMIN Clinical Trials Registry UMIN000042943; https://tinyurl.com/ydrchfas
Effects of Internal and External Factors on Hospital Data Breaches: Quantitative Study
Authors: Dolezel Diane , Beauvais Brad , Stigler Granados Paula , Fulton Lawrence , Kruse Clemens Scott 
Published: November 2023

Background
Health care data breaches are the most rapidly increasing type of cybercrime; however, the predictors of health care data breaches are uncertain.

Objective
This quantitative study aims to develop a predictive model to explain the number of hospital data breaches at the county level.

Methods
This study evaluated data consolidated at the county level from 1032 short-term acute care hospitals. We considered the association between data breach occurrence (a dichotomous variable), predictors based on county demographics, and socioeconomics, average hospital workload, facility type, and average performance on several hospital financial metrics using 3 model types: logistic regression, perceptron, and support vector machine.

Results
The model coefficient performance metrics indicated convergent validity across the 3 model types for all variables except bad debt and the factor level accounting for counties with >20% and up to 40% Hispanic populations, both of which had mixed coefficient directionality. The support vector machine model performed the classification task best based on all metrics (accuracy, precision, recall, F1-score). All the 3 models performed the classification task well with directional congruence of weights. From the logistic regression model, the top 5 odds ratios (indicating a higher risk of breach) included inpatient workload, medical center status, pediatric trauma center status, accounts receivable, and the number of outpatient visits, in high to low order. The bottom 5 odds ratios (indicating the lowest odds of experiencing a data breach) occurred for counties with Black populations of >20% and <40%, >80% and <100%, and >40% but <60%, as well as counties with ≤20% Asian or between 80% and 100% Hispanic individuals. Our results are in line with those of other studies that determined that patient workload, facility type, and financial outcomes were associated with the likelihood of health care data breach occurrence.

Conclusions
The results of this study provide a predictive model for health care data breaches that may guide health care managers to reduce the risk of data breaches by raising awareness of the risk factors.
Trends and Specific Causes of Cardiovascular Mortality after Kidney Transplantation in Finland
Authors: Helve Salla , Helanterä Ilkka , Laine Mika , Nieminen Tuomo , Finne Patrik , Helve Jaakko 
Published: November 2023

Background
Cardiovascular diseases are an important cause of mortality in patients who have undergone kidney transplantation, but the knowledge on trends of cardiovascular mortality and specific causes of cardiovascular death among these patients is scarce.

Methods
Our aim was to compare the cardiovascular mortality rates after kidney transplantation in Finland between 1990–1999, 2000–2009, and 2010–2019 using data from the Finnish Registry for Kidney Diseases. We analyzed 1-year and long-term cardiovascular mortality rates as well as the specific causes of cardiovascular death and the trends in them.

Results
In total, 4946 patients underwent first kidney transplantation in 1990–2019. During the follow-up time (median 8.3 years, interquartile range 4.0–14.5), there were 1392 deaths, of which 582 were cardiovascular deaths. In an unadjusted Cox regression model, the risk of long-term cardiovascular mortality was similar in the different periods. However, when adjusted for age, sex, duration of dialysis, and cause of kidney disease, the long-term cardiovascular mortality risk was significantly lower in 2000–2009 and 2010–2019 (hazard ratio 0.60 [95% confidence interval, 0.49 to 0.73] and hazard ratio 0.51 [95% confidence interval, 0.39 to 0.66], respectively) compared with 1990–1999. The results were similar regarding 1-year cardiovascular mortality. The distribution of different causes of cardiovascular death remained unchanged during the study period, with coronary artery disease accounting for 47% of deaths. During the first year after transplantation, pulmonary embolisms and arrhythmias were more common than in the long term.

Conclusions
Cardiovascular disease remained the most common cause of death in kidney transplant recipients, but adjusted cardiovascular mortality risk has decreased significantly during the past three decades. Coronary artery disease was the most frequent cause of cardiovascular death, and the proportion of coronary artery disease–related cardiovascular deaths increased after the first year after transplantation.
E-Preservation of Old and Rare Books: A Structured Approach for Creating a Digital Collection
Authors: Chakravarty Sangeeta 
Published: November 2023

Antique books, old and rare documents are fragile and vulnerable to different hazards. Preserving them for an extended period is a real challenge. From ancient times people started expressing their knowledge by writing and keeping records and subsequently started collecting and storing these at later ages as antique materials. These can be seen in different museums, libraries, archives, individual households, and other places all over the world. Preserving and conserving these antique, old and rare books, documents etc. in good condition is a challenge for librarians, conservators, preservation administrators or persons associated with storing these. In this paper, details of the digital preservation of such a collection available in the Directorate of Historical and Antiquarian Studies (DHAS), Guwahati, Assam, India, are discussed. DHAS is a Government of Assam wing and is mainly mandated to collect, preserve and research historical and antiquarian resources. The collection of DHAS is one of the oldest collections and has been serving as a study and research centre in Assam since 1928. A special drive has been taken for the digital preservation of an identified part of the collection, with grant support from the National Archive of India. This paper discusses the entire project process starting from the project proposal formulation to the structuring of the digital collection. The paper sequentially discusses the different steps of the entire work of digitization of a collection of 241 old and rare books from the main collection of DHAS.
Análisis de componentes críticos de una plegadora hidráulica con elementos finitos
Authors: Nivicela- Castro Luis Miguel , Peñarreta-Aguilar Carlos Gonzalo , Calle- Siguencia John Ignacio 
Published: November 2023

El presente trabajo realizado en el mes de mayo del 2021, en la Universidad Politécnica Salesiana con Sede en CUENCAECUADOR, se propone evaluar el diseño de partes de una plegadora hidráulica sometidas a una fuerza máxima de compresión que deben soportar los materiales a través de cálculos matemáticos y análisis estático de elementos fi nitos utilizando la herramienta SolidWorks en los aceros comerciales, por la norma de la Sociedad Estadounidense para Pruebas y Materiales, ASTM A36, la norma del Instituto Americano del Hierro y el Acero AISI SAE 1020 y AISI SAE 1045. El principal objetivo de este estudio se lo realizó en los componentes que están expuestos a esta fuerza, lo que dió como resultado el mejor espesor con respecto al factor de seguridad para la construcción estructural, produciendo deformaciones menores en los parámetros de esfuerzo máximo de compresión, flexión y pandeo. Los resultados revelan que la menor deformación en base a los criterios antes mencionados se obtuvo para el acero SAE 1045, y es de 0.19 mm para el punzón y 0.04 para la matriz de plegado, por lo tanto, se debe de optar para la construcción de los diferentes elementos utilizados en esta investigación, siendo este, analizado bajo las mismas condiciones iniciales. Finalmente, con los resultados obtenidos, se ha determinado el material y espesor óptimos para la construcción de los diferentes elementos principales de la máquina.
Ijon Practice on Landowner Rice Farming; Agency-Structure Perspective
Authors: Azuz Faidah , Nonci Nurmi , Iskandar Abdul Malik , Bachri Syamsul , Masdar Muhammad , Harifuddin Harifuddin , Azuz Fidaan Husein 
Published: November 2023

The status of farmers in the socio-economic study of agriculture referring to land ownership consists of landowner farmer, tenant farmer, and sharecropper. Landowner farmer holds the highest position. Many landowner farmers have been trapped in “Ijon” practice for years, which makes them work on their own land to pay their debts for a long period of time. The purpose of this study is to find out the background of farmers who were involved in the ijon practice, the reasons behind their entanglement in the ijon practice, the uses of loans, and how the loans were paid. The study location was village of XYZ in East Nusa Tenggara Province, involving 22 farmers who were involved in the practice of ijon. This study used a qualitative analysis of agency structure from Gidden’s perspective. This paper concludes that farmers were involved in the ijon practice to meet urgent non-productive needs. Most of the farmers’ earnings are used to pay debts. Farmers who are trapped in the ijon system for a long period of time will bear the status of “the landowner farmers who work as farm laborers on their own land.” This status has yet to be categorized in the agricultural economic approach.