bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Claims about Potential Human Beings
Authors: Persson Ingmar 
Published: October 2003

ABSTRACTIt seems that at conception something is formed which, due to its genetic make‐up, has the potentiality to develop into a full‐blown human being. Many believe that in virtue of this potentiality, this organism, the human zygote or early embryo, has an intrinsic value which makes it wrong to use or produce it merely as a means to some end, e.g., some scientific end such as to produce embryonic stem cells. Against this it is here argued, first, that it does not follow from the fact that something has a potential to become a (fully developed) human being that it already is a human being (in a rudimentary sense). In fact, a human being begins to exist no earlier than a couple of weeks after conception, at the stage known as gastrulation. Thus, even granted the questionable assumption that something has intrinsic value in virtue of being a human being, the zygote will not have intrinsic value. Secondly, the value an embryo has in virtue of its potentiality to become a full‐blown human being can only be instrumental, a value as a means. But of course it cannot be wrong to treat that which has merely instrumental value as a mere means or instrument to some end.
Human Cloning: Category, Dignity, and the Role of Bioethics
Authors: Shuster Evelyne 
Published: October 2003

ABSTRACTHuman cloning has been simultaneously a running joke for massive worldwide publicity of fringe groups like the Raelians, and the core issue of an international movement at the United Nations in support of a treaty to ban the use of cloning techniques to produce a child (so called reproductive cloning). Yet, even though debates on human cloning have greatly increased since the birth of Dolly, the clone sheep, in 1997, we continue to wonder whether cloning is after all any different from other methods of medically assisted reproduction, and what exactly makes cloning an ‘affront to the dignity of humans.’ Categories we adopt matter mightily as they inform but can also misinform and lead to mistaken and unproductive decisions. And thus bioethicists have a responsibility to ensure that the proper categories are used in the cloning debates and denounce those who try to win the ethical debate through well‐crafted labels rather than well‐reasoned argumentations. But it is as important for bioethicists to take a position on broad issues such as human cloning and species altering interventions. One ‘natural question’ would be, for example, should there be an international treaty to ban human reproductive cloning?
Voluntary Euthanasia: A Utilitarian Perspective
Authors: Singer Peter 
Published: October 2003

ABSTRACTBelgium legalised voluntary euthanasia in 2002, thus ending the long isolation of the Netherlands as the only country in which doctors could openly give lethal injections to patients who have requested help in dying. Meanwhile in Oregon, in the United States, doctors may prescribe drugs for terminally ill patients, who can use them to end their life – if they are able to swallow and digest them. But despite President Bush's oft‐repeated statements that his philosophy is to ‘trust individuals to make the right decisions’ and his opposition to ‘distant bureaucracies’, his administration is doing its best to prevent Oregonians acting in accordance with a law that its voters have twice ratified. The situation regarding voluntary euthanasia around the world is therefore very much in flux.This essay reviews ethical arguments regarding voluntary euthanasia and physician‐assisted suicide from a utilitarian perspective. I shall begin by asking why it is normally wrong to kill an innocent person, and whether these reasons apply to aiding a person who, when rational and competent, asks to be killed or given the means to commit suicide. Then I shall consider more specific utilitarian arguments for and against permitting voluntary euthanasia.
Can We Help Addicts Become more Autonomous? Inside the Mind of An Addict
Authors: Spriggs Merle 
Published: October 2003

ABSTRACTI examine the impact of addiction on autonomy in terms of the standard literature on addiction – referred to also as ‘substance dependence.’1 Then in terms of the criteria for substance dependence, by developing a set of practical strategies to help people with addictions think more clearly, I test the idea whether addicts can be helped to become more autonomous. Given that unsuccessful attempts to quit constitute part of the criteria of substance dependence, I look at what goes wrong when people try to quit using a substance. The subjective experience of addiction is an important aid in understanding addiction and first person accounts and literary characterisations of addiction provide insight into the addict's mind and assist us in deciding whether addicts can be helped to become more autonomous.
Welfarism Versus ‘Free Enterprise’: Considerations Of Power And Justice In The Philippine Healthcare System
Authors: Sy Peter A. 
Published: October 2003

ABSTRACTThe just distribution of benefits and burdens of healthcare, at least in the contemporary Philippine context, is an issue that gravitates towards two opposing doctrines of welfarism and ‘free enterprise.’ Supported largely by popular opinion, welfarism maintains that social welfare and healthcare are primarily the responsibility of the government. Free enterprise (FE) doctrine, on the other hand, maintains that social welfare is basically a market function and that healthcare should be a private industry that operates under competitive conditions with minimal government control. I will examine the ethical implications of these two doctrines as they inform healthcare programmes by business and government, namely: (a) the Devolution of Health Services and (b) the Philippine Health Maintenance Organization (HMO). I will argue that these doctrines and the health programmes they inform are deficient in following respects: (1) equitable access to healthcare, (2) individual needs for premium healthcare, (3) optimal utilisation of health resources, and (4) the equitable assignment of burdens that healthcare entails. These respects, as considerations of justice, are consistent with an operational definition of ‘power’ proposed here as ‘access to and control of resources.’
The Effect of “Front‐Loading” Problem‐Solving on Product Development Performance
Authors: Thomke Stefan , Fujimoto Takahiro 
Published: October 2003

In recent years, there has been a growing interest in the link between problem‐solving capabilities and product development performance. In this article, the authors apply a problem‐solving perspective to the management of product development and suggest how shifting the identification and solving of problems—a concept that they define as front‐loading—can reduce development time and cost and thus free up resources to be more innovative in the marketplace.The authors develop a framework of front‐loading problem‐solving and present related examples and case evidence from development practice. These examples include Boeing's and Chrysler's experience with the use of “digital mock‐ups” to identify interference problems that are very costly to solve if identified further downstream—sometimes as late as during or—after first full‐scale assembly.In the article, the authors propose that front‐loading can be achieved using a number of different approaches, two of which are discussed in detail: (1) project‐to‐project knowledge transfer—leverage previous projects by transferring problem and solution‐specific information to new projects; and (2) rapid problem‐solving—leverage advanced technologies and methods to increase the overall rate at which development problems are identified and solved. Methods for improving project‐to‐project knowledge transfer include the effective use of “postmortems,” which are records of post‐project learning and thus can be instrumental in carrying forward the knowledge from current and past projects. As the article suggests, rapid problem‐solving can be achieved by optimally combining new technologies (such as computer simulation) that allow for faster problem‐solving cycles with traditional technologies (such as late stage prototypes), which usually provide higher fidelity.A field study of front‐loading at Toyota Motor Corporation shows how a systematic effort to front‐load its development process has, in effect, shifted problem‐identification and problem‐solving to earlier stages of product development. They conclude the article with a discussion of other approaches to front‐load problem‐solving in product development and propose how a problem‐solving perspective can help managers to build capabilities for higher development performance.
From Experience: Harnessing Tacit Knowledge to Achieve Breakthrough Innovation
Authors: Mascitelli Ronald 
Published: October 2003

The ability to create a stream of revolutionary new products can represent a sustainable competitive advantage for firms in almost any industry. Whereas evolutionary product improvements often follow predictable trajectories, breakthrough innovations involve unexpected leaps of creativity and insight. Despite its strategic importance, however, little is known about the process by which innovators achieve these valuable breakthroughs. This article proposes that breakthrough innovations result from the harnessing of tacit knowledge possessed by individuals and project teams. Tacit knowledge lies below the surface of conscious thought and is accumulated through a lifetime of experience, experimentation, perception, and learning by doing. Managers who can tap into this vast pool of creative energy can elevate the innovative capabilities of their teams well beyond the incremental and mundane.The article begins by establishing the vital importance of breakthrough innovations to the competitiveness of firms. This strategic mandate is followed by a brief discussion of the nature and implications of tacit knowledge in the context of innovation. The remainder of the article describes three mutually reinforcing methods for encouraging the explication and sharing of tacit knowledge among design team members. The ultimate goal is to establish a generative atmosphere for breakthrough innovation, in which divergent thinking, improvisation, and artistic creativity merge with the practical demands of the product development process.The first step toward harnessing the creative power of tacit knowledge is to foster the emotional commitment and deep personal involvement of design team members. Managers can accomplish this goal through the development of inspiring “innovation stories,” encouragement of reasonable risk‐taking and experimentation, building of unique team identities, and displaying unbridled confidence in a team's creative abilities. Once the emotional commitment of team members has been assured, two techniques are proposed as catalysts for breakthroughs derived from tacit knowledge. These methods are based on evidence that intimate physical interaction during the creative process, both person to object and person to person, may be a catalyst for tacit insights. The first technique highlights the use of early and frequent prototyping as a powerful focal point for the explication of tacit knowledge from both the design team and potential customers. The second technique involves the encouragement of face‐to‐face interaction between innovators during product development, thereby enabling creative improvisation and real‐time knowledge sharing.Several implications for managers are highlighted, including the need for a greater emphasis on employee retention, the importance of developing a nurturing environment for innovation, and the value of intimate physical interaction, including early prototyping, indwelling with customers, and co‐location of teams wherever possible.
Pioneering Advantage in New Service Development: A Multi‐Country Study of Managerial Perceptions
Authors: Song X. Michael , Di Benedetto C. Anthony , Song Lisa Z. 
Published: October 2003

Pioneering advantage in manufacturing firms has received much attention in the management and marketing literature. Few research studies, however, have been conducted to investigate the pioneering advantages and disadvantages involved in new service development, especially across several geographic regions. We build a theoretical framework of pioneering advantage in service industries based on the distinguishing characteristics of services. From this framework, we develop a set of testable propositions about the importance of several types of pioneering advantage (economic, preemptive, technological, and behavioral advantages) to service managers. Specifically, we propose that all of these types of pioneering advantages are important to service managers, and that these managers perceive that pioneering results in improved firm performance. We also propose that, due to the distinguishing characteristics of services such as intangibility and heterogeneity, service managers will not perceive the risks of pioneering in a service industry to be severe. In addition, we propose that certain types of pioneering advantage will be more important to service managers in Western countries than in Asian Pacific countries due to cultural and business environmental differences. In particular, we propose that service managers from Western firms perceive preemptive advantages of pioneering to be more important than do their Asian Pacific counterparts, and service managers from Asian Pacific firms perceive behavioral advantages of pioneering to be more important than do their Western counterparts.To test our propositions empirically, we develop a set of pioneering principles from the literature. We then collect and analyze data from a sample of 982 senior managers in service industries from nine countries: the United States, the United Kingdom, Germany, Japan, China, Taiwan, Hong Kong,1 South Korea, and Singapore. We find evidence of several significant cross‐cultural differences consistent with our propositions. In fact, seven of the eight propositions are strongly or partially supported. The only nonsupported proposition concerned the importance of technological advantage. We find that technological advantages of pioneering are much less important to service managers than are other pioneering advantages. We conclude with strategic recommendations for managers involved in new service development and international or global competition, and provide directions for future research. We note that the insights from this study can help managers from both the West and the Asian Pacific region to better understand their global competitors who pursue a new service pioneering strategy, and can potentially help them select entry deterrence strategies more effectively.
Relocation Opportunities and Mortgage Default
Authors: Giliberto S. Michael , Houston Arthur L. 
Published: October 2003

This paper presents a theoretical model of residential mortgage default when borrowers face beneficial as well as costly relocation opportunities. It amplifies and extends previous work by providing explicit conditions leading to default. The model also establishes when a borrower's relocation decision and default decision are dependent and when they are not.A central result is that there is a range of book equity wherein the decision to default is not determined solely by the current level of equity or the borrower's ability to continue the mortgage payments. Rather, various costs and benefits, both tangible and intangible, enter into the decision. Specific conditions are identified that lead to relocation without default, default and relocation, and no default or relocation. The effects of changes in the variables upon default probability are presented.Assuming that the borrower does not wish to retain ownership in the property, the model also predicts whether an individual borrower will choose prepayment or default when a relocation is made. The choice depends on the value of the relocation opportunity faced by the borrower, as well as financial variables such as house value, mortgage balance, and transaction costs. This finding suggests that existing empirical analyses of default may have omitted explanatory variables.
The Insolvent Thrifts of 1982: Where Are They Now?
Authors: Rudolph Patricia M. 
Published: October 2003

In 1982, 237 thrifts were GAAP (Generally Accepted Accounting Principle) insolvent. By 1987, 92 of these were either merged or closed and 77 remained insolvent. The remaining 68 were GAAP solvent with an average GAAP‐to‐total‐assets ratio of 5.6%. The purpose of this paper is to identify the factors that affected the probability of solvency for the 1982‐insolvent thrifts over the period 1983–1987.To identify these factors, the probability of insolvency is modeled in each year between 1983 and 1987 using logistic regression. Because a thrift can earn its way out of insolvency or raise outside capital, the probability of solvency is a function of the infusion of outside capital along with balance sheet and income statement ratios reflecting the thrifts earning ability. The only variable consistently significant in each year is the variable reflecting the raising of outside capital.
Risk and Return on Real Estate: Evidence from Equity REITs
Authors: Chan K. C. , Hendershott Patric H. , Sanders Anthony B. 
Published: October 2003

We analyze monthly returns on an equally weighted index of eighteen to twenty‐three equity (real property) real estate investment trusts (REITs) that were traded on major stock exchanges over the 1973–87 period. We employ a multifactor Arbitrage Pricing Model using prespecified macroeconomic factors. We also test whether equity REIT returns are related to changes in the discount on closed‐end stock funds, which seems plausible given the closed‐end nature of REITs.Three factors, and the percentage change in the discount on closed‐end stock funds, consistently drive equity REIT returns: unexpected inflation and changes in the risk and term structures of interest rates. The impacts of these variables on equity REIT returns is around 60% of the impacts on corporate stock returns generally. As expected, the impacts are greater for more heavily levered REITs than for less levered REITs. Real estate, at least as measured by the return performance of equity REITs, is less risky than stocks generally, but does not offer a superior risk‐adjusted return and is not a hedge against unexpected inflation.
Windfall Gains on the Swedish Housing Market: The Effects of Queueing for a Cooperative Dwelling
Authors: Berger Tommy , Turner Bengt 
Published: October 2003

The cooperative housing sector in Sweden consists of one market for new dwellings where the downpayment and rent is fixed, and where the dwellings are allocated through a queue, and one market for used dwellings, where all units are bought and sold freely with a transaction price determined by market conditions. As the transaction price usually exceeds the down‐payment, substantial windfall gains accrue to those achieving a dwelling through the queue. Regression analysis reveals that this ratio is on average nearly three. The ratio varies, however, depending on the local housing market situation. It is argued that the ratio is a better indication on the demand situation in the local housing market than is provided through information on the length of the queue at the municipal exchequer.A logit analysis is used to find out which households receive these windfall gains. It is shown that the probability of acquiring a dwelling through the queue, and thus capturing the windfall gain, is positively correlated with income and family size. The conclusion is that the cooperative queues do not have a redistributive effect on wealth in society, quite opposite the housing policy intention upon which the Swedish cooperative movement was founded.
Housing Price Indices Based on All Transactions Compared to Repeat Subsamples
Authors: Clapp John M. , Giaccotto Carmelo , Tirtiroglu Dogan 
Published: October 2003

The set of real properties sold during a given period of time may be subdivided into several subsets comprising those properties that sold only once, only twice, and three or more times. The major reason for subdividing the sample is to allow estimation of residential price indices by the repeat‐sales methodology. The purpose of this paper is to compare price indices estimated with the repeat subsample to indices based on the entire sample.Our data for five metropolitan areas indicate that cumulative price trends for the repeat subsamples can differ from the full samples over periods ranging from two to ten quarters. While short‐term price trends can differ widely, there are no systematic differences among the samples over periods of three years or more. The data indicate that arbitrage typically forces prices for the repeat sample to grow at the same rate as those for the full sample. Whether this would be the case in areas experiencing greater disequilibrium than our towns in the Hartford area is uncertain.
Geographical Cost of Living Differences: An Update
Authors: McMahon Walter W. 
Published: October 2003

This article develops a method for estimating current geographical differences in the cost of living index for all states for 1981–1990. These estimates based on BLS data are shown to correspond closely to statewide cost of living estimates for 1989 based on the American Chamber of Commerce Research Association data for selected cities.Living costs are highest in Hawaii, Alaska, Connecticut, Washington D.C., New Jersey, Massachusetts, New York, and California. They are lower in Mississippi, West Virginia, Arkansas, Idaho, and Utah. The basic pattern persists since 1977 with shifts related to economic growth rates.
A Potential Food-Grade Cloning Vector for
Streptococcus thermophilus
That Uses Cadmium Resistance as the Selectable Marker
Authors: Wong Wing Yee , Su Ping , Allison Gwen E. , Liu Chun-Qiang , Dunn Noel W. 
Published: October 2003

ABSTRACT

A potential food-grade cloning vector, pND919, was constructed and transformed into
S. thermophilus
ST3-1, a plasmid-free strain. The vector contains DNAs from two different food-approved organisms,
Streptococcus thermophilus
and
Lactococcus lactis
. The 5.0-kb pND919 is a derivative of the cloning vector pND918 (9.3 kb) and was constructed by deletion of the 4.3-kb region of pND918 which contained DNA from non-food-approved organisms. pND919 carries a heterologous native cadmium resistance selectable marker from
L. lactis
M71 and expresses the Cd
r
phenotype in
S. thermophilus
transformants. With the
S. thermophilus
replicon derived from the shuttle vector pND913, pND919 is able to replicate in the two
S. thermophilus
industrial strains tested, ST3-1 and ST4-1. Its relatively high retention rate in
S. thermophilus
further indicates its usefulness as a potential food-grade cloning vector. To our knowledge, this is the first report of a replicative potential food-grade vector for the industrially important organism
S. thermophilus
.