bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the management scheme of urban flooding based on GIS technology
Authors: Meili Chen , Samat Narimah , Tilaki Mohammad Javad Maghsoodi 
Published: January 2024

Abstract
With rapid urbanization, flooding disasters caused by heavy rainfall and floods have brought huge economic and social losses. Therefore, it is critical to seek a scientific and effective stormwater management solution. Using GIS technology, this study focuses on the growing urban flooding problem in three stages: before, during, and after the rainstorm. In the pre-storm stage, GIS is used for flood risk assessment and prediction management to provide accurate early warning information and decision support so that timely countermeasures can be taken. In the mid-storm stage, GIS plays a key role in command and dispatch and emergency response, enabling task assignment and dispatch optimization, and facilitating inter-departmental collaboration. In the post-storm phase, GIS technology is used to identify flooding problem areas, evaluate management effectiveness, and offer support for summarizing lessons learned and improving the urban flooding management system. Hence, this study provides scientific and efficient flood management solutions to reduce flood risks, improve city resilience to floods, and promote urban sustainable development. Through the application of GIS technology, the proposed findings will reveal that spatial analysis, data management, and decision support functions can be employed to provide comprehensive and systematic solutions for urban flood management.
Man versus machine: cost and carbon emission savings of 4G-connected Artificial Intelligence technology for classifying species in camera trap images
Authors: Smith James , Wycherley Ashleigh , Mulvaney Josh , Lennane Nathan , Reynolds Emily , Monks Cheryl-Ann , Evans Tom , Mooney Trish , Fancourt Bronwyn 
Published: January 2024

Abstract
Timely and accurate detection and identification of species are crucial for monitoring wildlife for conservation and management. Technological advances, including connectivity of camera traps to mobile phone networks and artificial intelligence (AI) algorithms for automated species identification, can potentially improve the timeliness and accuracy of species detection and identification. Adoption of this new technology, however, is often seen as cost-prohibitive as it has been difficult to calculate the cost savings or qualitative benefits over the life of the program. We developed a decision tool to quantify potential cost savings associated with incorporating the use of mobile phone network connectivity and AI technologies into monitoring programs. Using a feral cat eradication program as a case study, we used our decision tool to quantify technology-related savings in costs and carbon emissions, and compared the accuracy of AI species identification to that of experienced human observers. Over the life of the program, AI technology yielded cost savings of $0.27m and when coupled with mobile phone network connectivity, AI saved $2.15m and 115,838kg in carbon emissions, with AI algorithms outperforming human observers in both speed and accuracy. Our case study demonstrates how advanced technologies can improve accuracy and cost-effectiveness and improve monitoring program efficiencies.
Did alcohol facilitate the evolution of complex societies?
Authors: Hrnčíř Václav , Chira Angela , Gray Russell 
Published: January 2024

Abstract
The size and complexity of human societies increased dramatically over the Holocene. Researchers have proposed a variety of potential drivers of this major transition1–4, including our predilection for alcoholic beverages5–7. This "drunk" hypothesis argues that drinking alcohol facilitated the rise of complex societies because it promotes social bonding and enhances human creativity5. However, systematic cross-cultural evidence for the claim is lacking. Here we test this hypothesis with a global sample of 186 largely non-industrial societies8. We find a positive (albeit modest) relationship between the presence of indigenous alcoholic beverages and the level of political complexity, even after controlling for several potential confounders, including common ancestry, spatial proximity, environmental productivity and agricultural intensity. Furthermore, we find that the largest effect of alcohol on political complexity is in less integrated societies, such as “acephalous” societies and “simple chiefdoms”. Our results support the idea that group-level social benefits of alcohol tended to outweigh its disruptive effects, at least in the case of traditional low-alcohol beverages, and thus positively contributed to the evolution of human societies.
Land surface temperature variations in a low-latitude high-altitude mountainous area of southwest China
Authors: Huo Hong , Sun Changping 
Published: January 2024

Abstract

High-altitude areas are thought to be more sensitive and responsive to climate change, but long-term series of land surface temperature (LST) observations are still inadequate in low-latitude high-altitude mountainous areas. In this paper we comprehensively investigate the spatiotemporal variations in the LST and its dominant driving factors at both annual and seasonal scales from 2001 to 2020 based on the long-term series of MODIS data over the Yunnan Plateau (YNP) in southwest China, with a special focus on elevation-dependent warming (EDW). The results indicated that the annual LST showed a general increasing trend over the past 20 years, with an average rate of 0.18°C decade− 1, being stronger during summer season (0.47°C decade− 1). Moreover, an obvious asymmetric diurnal warming was observed; the nighttime warming rate was 0.43°C decade− 1, which is much faster than the daytime cooling rate (− 0.08°C decade− 1). We also confirmed the presence of EDW; it behaved more strongly at high elevations (above 3500 m) at a rate of 0.41 ºC decade− 1. Spatially, a warming trend was found in most areas, especially in high-cold mountains, hot-dry river valleys, and the tropics. In contrast, in the northeastern YNP and western side of the Ailao Mountains a cooling trend was observed. In most areas, air temperature is the dominant climatic factor influencing changes in LST at an annual, autumn and winter timescales, while precipitation plays a major role in annual LST changes in the northwest and northeast. LST and warming trend largely differenced with respect to land cover types, with the highest values occurring in built-up lands. This research is expected to contribute to a better understanding of surface-atmosphere interaction and climate change processes in YNP.
Microbial iron limitation in the ocean’s twilight zone
Authors: Repeta Daniel , Li Jingxuan , Babcock-Adams Lydia , Boiteau Rene , McIlivin Matthew , Manck Lauren , Sieber Matthias , Lanning Nathan , Bundy Randelle , Bian Xiaopeng , Streanga Iulia-Madalina , Granzow Benjamin , Church Matthew , Fitzsimmons Jessica , John Seth , Conway Tim 
Published: January 2024

Abstract

One of the major advances in ocean biogeochemistry achieved over the past three decades is an understanding of how nutrients, primarily nitrate, phosphate and iron (Fe), combine in complex patterns to limit and shape primary production in the surface ocean1-3. Below the surface ocean, remineralization of sinking organic matter rapidly regenerates nutrients, and microbial metabolism in the upper mesopelagic “twilight zone” (200-500 m) instead appears to be limited by the delivery of labile organic carbon4,5. In contrast to the large number of studies describing nutrient limitation in ocean surface waters, nutrient limitation of microbial production in the mesopelagic has been unexplored. Here we report the distribution and uptake of siderophores, biomarkers for microbial Fe limitation6, across a meridional section of the eastern Pacific Ocean. Siderophore concentrations were high in chronically Fe limited surface waters, but they were also surprisingly high in the twilight zone underlying the North and South Pacific subtropical gyres, two key ecosystems for the global carbon cycle. Bacterial Fe deficiency due to low Fe availability is likely characteristic of the twilight zone in several large ocean basins, greatly expanding the region of the marine water column where nutrients limit microbial metabolism with potentially significant impacts on ocean carbon storage.
Acquired resistance to CDK4/6 inhibition is associated with dysregulation of multiple pathways including cyclin D-CDK4/6-RB, EGFR/HER, AKT/mTOR and IFN signaling
Authors: Spears Melanie , Bathurst Lauren , Liao Linda , Hopkins Megan , Crozier Cheryl , Trinh Quang , III Emanuel Petricoin , Bayani Jane , Bartlett John 
Published: January 2024

Abstract
While the use of CDK4/6 inhibitors has significantly improved outcomes for patients with ER+/HER2- tumours, understanding the mechanisms responsible for resistance is essential to identify predictive biomarkers and alternative treatment options after tumour progression. To this end, we developed in-vitro models of acquired resistance to palbociclib and abemaciclib using MCF7 and T47D cell lines. Genomic, transcriptomic, and proteomic analyses were used to identify potential actionable molecular alterations in these models. Results show that acquired resistance was associated with dysregulation of multiple signaling pathways, including cyclin D-CDK4/6-RB, EGFR/HER and AKT/mTORC1. Strikingly, acquired resistance across all cell lines was also associated with an upregulated interferon (IFN) response. Expression of an IFN-based gene signature derived from these models was upregulated in breast cancer cell lines and early-stage tumours intrinsically resistant to CDK4/6i, and thus warrants further clinical evaluation as a predictive biomarker of resistance.
Metabolomic spectral biomarker selection towards early diagnostic of Fusarium oxysporum in tomato
Authors: García-Barrera Laura J. , Meza-Zamora Stefani A. , Noa-Carrazana Juan C. , Macuil Raul Jacobo Delgado 
Published: January 2024

Abstract

The interaction of phytopathogenic organisms and plants generates physiological and biochemical changes in the latter, however the effects in the plants are rarely visible in the first stages of infection. Novel optical techniques can help to improve the early detection of the phytopathogenic organisms in tomato plants without the plant sacrifice. In this work infrared spectroscopy and chemometric methods were used in an intent to determinate the effects of Fusarium oxysporum in tomato leaves cultivated in pots. Fusarium oxysporum was molecular identified and its pathogenicity was test in vitro. Three treatments were evaluated, control, water stress, and fungal inoculated plants (1x108 conidia/ml); for 55 days post infection in pots in greenhouse under semi controlled conditions. Phenotypical results were followed twice a week for 8 weeks, the phenotypical characteristics were very similar in almost all sampling times except in height specially in the first 27 days post infection, after this time the height was similar in the three treatments. The stalk and root dried matter analysis does not show statistical differences; however, the infrared results, develop in the adaxial surface of leaves, shows differences in peaks associated to salicylic acid, jasmonic acid, abscisic acid, and proline in the first 27 days post infection. The PCA-LDA development in the time groups, help to have a good classification in the first 27 days as first group, and in the rest of the sampling times as second group.
Understanding the drivers of continued mpox transmission in the United States: a modeling study
Authors: Kipshidze Nodar , Klein Eili , Yang Wan 
Published: January 2024

Abstract
The 2022 mpox epidemic in the United States (U.S.) peaked in the summer of 2022, but over a year later, new cases continue to emerge. To understand why mpox continues to spread, albeit at low levels, we explored three mechanisms: (1) underdetection of cases, (2) waning immune protection from vaccination, and (3) waning immune protection from prior infection. We refined a multilayer epidemic network model to simulate these mechanisms and fit this model to the 2022 mpox outbreaks in Chicago, New York City, and San Francisco. Analyses across mechanisms suggest that underdetection was the most likely driver of prolonged transmission. Furthermore, the duration of simulated outbreaks was most sensitive to changes in the proportion of undetected cases. Our findings underscore the need for enhanced surveillance to capture the true scope of mpox transmission in the U.S., reduce the possibility of future resurgence, and enable effective outreach to key affected populations.
Association of hereditary hemochromatosis with portal vein thrombosis: A national inpatient sample (2016-2020) analysis
Authors: Kharel Himal , Pokhrel Nishan Babu , Kharel Zeni , Bhandari Samikchhya Keshary , Niu Chengu , Jain Tripti , Sanjeevi Aditya 
Published: January 2024

Abstract
Hereditary hemochromatosis is a common inherited metabolic disorder of iron metabolism with variable penetrance. Portal vein thrombosis has several well-known causes including cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen (acute appendicitis, acute diverticulitis, and acute pancreatitis), intra-abdominal malignancy, intra-abdominal surgery, and thrombophilia. It is unknown whether hereditary hemochromatosis is associated with portal vein thrombosis. A retrospective analysis of the NIS database from 2016 to 2020 was conducted using International Classification of Diseases (ICD-10) codes to identify hospitalizations with portal vein thrombosis. We used Fischer's exact test to compare proportions and the student's t-test to compare continuous variables. We used multivariate regression analysis to calculate the adjusted odds ratio after controlling for age, gender, primary payer, Charlson Comorbidity index, cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen (acute appendicitis, acute diverticulitis, and acute pancreatitis), intra-abdominal malignancy, intra-abdominal surgery, history of past thrombosis, thrombophilia, end stage renal disease, obesity, smoking, and hyperlipidemia.There were 25805 hospitalizations with primary diagnosis of portal vein thrombosis. Multivariate logistic regression showed that hereditary hemochromatosis was independently associated with portal vein thrombosis (OR = 4.7, 95% CI = 1.15 to 19.35, p-value = 0.03) along with cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen, intra-abdominal malignancy, history of thrombosis, history of abdominal surgery, history of thrombophilia, and end stage renal disease among other factors.
Problems of operation of positive pressure ventilators on the basis of surveys of Polish officers of the State Fire Service
Authors: Kaczmarzyk Piotr , Warguła Łukasz , Janik Paweł , Krawiec Piotr , Bąk Damian , Klapsa Wojciech 
Published: January 2024

Abstract

Positive pressure ventilators used by 97.7% of officers of the National Fire Service in Poland, are characterized by work that is not in line with the expectations of the firefighters. In order to improve the technical and operational features of these devices, a survey was conducted among 25,000 eligible firefighters, identifying the application of these devices, problems in use and expected development directions. A total of 682 officers voluntarily completed the survey. Based on their findings, it was determined that ventilators are most often used to smoke out buildings after or during a fire. Mentioned problems when using these devices were mainly noise (78.2%), exhaust emissions (68.5%), and impediments to mobility through the device’s relatively heavy weight (40.2%). Other inconveniences were mentioned by less than 20% of firefighters. Polish firefighters expect the development of these devices mainly in terms of the above-mentioned features (noise reduction (81.7%) and reduction of the weight and size of the ventilators (about 50%)). Other expectations relate to the improvement of smoke removal in buildings: increasing the efficiency of smoke removal (46.4%) and efficiency regarding the rate of smoke removal in a building by increasing the size of the incoming airflow from the building’s surroundings (33.2%). About 15% of firefighters expect changes in the operation of the ventilator itself, that is, an increase in the effective operating time (electric ventilators) and an increase in the device’s uptime. The article also presents suggestions for device development based on the available state of the art.
High-resolution kinetics and cellular determinants of antibody response to SARS-CoV-2 over two years after COVID-19 vaccination
Authors: Dobaño Carlota , Rubio Rocío , Macià Dídac , Barrios Diana , Vidal Marta , Jimenez Alfons , Molinos-Albert Luis , Diaz Natalia , Canyelles Mar , Lara-Escandell Maria , Planchais Cyril , Santamaria Pere , Carolis Carlo , Izquierdo Luis , Aguilar Ruth , Moncunill Gemma 
Published: January 2024

Abstract
Despite widespread COVID-19 vaccine coverage, breakthrough infections are increasing, mainly driven by waning immunity and the emergence of SARS-CoV-2 Omicron variants. Here, we characterized the IgM, IgA and IgG kinetics in 55 visits over two years post-COVID-19 vaccination, and T-cell responses six months post-booster, in 31 healthy adults. Antibodies to Wuhan SARS-CoV-2 antigens and Alpha, Delta and Omicron variants were quantified by Luminex. SARS-CoV-2-specific T-cell responses were measured by activation-induced marker (AIM) and IFN-γ/IL-2 FluoroSpot assays. Antibody trajectories varied among isotypes. IgG decayed slowly during the first months and subsequently slowed down. IgA exhibited a rapid initial decay rate that decelerated stabilizing above the seropositivity threshold. Contrarily, IgM rapidly dropped to undetectable levels after primary vaccination. Importantly, three vaccine doses induced higher and more persistent anti-spike (S) IgG and IgA compared to two doses, whereas infection led to superior and longer-lasting IgG and IgA anti-S compared to three or two vaccine doses. Antibody levels to Omicron subvariants had shorter persistence than to ancestral virus. Finally, polyfunctional T cells correlated positively with subsequent IgA responses. These results revealed distinct isotype kinetics with non-constant decay rate and highlighted the benefits of booster doses in enhancing and sustaining antibody responses
WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway
Authors: Sun Kairui , Zhang Xuyang , Gan Ruihuan , Yan Yuxiang , Zhang Chaochao , Zheng Dali , Lu Youguang 
Published: January 2024

Abstract
Objectives
5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets. In recent years, the WNT signaling pathway has been increasingly studied in cancer drug resistance; however, the role of WNT3, a ligand of the canonical WNT signaling pathway, in OSCC drug resistance is not clear. This study delved into this potential connection.
Materials and Methods
5FU-resistant cell lines were established by gradually elevating the drug concentration in the culture medium. Differential gene expressions between parental and resistant cells underwent RNA sequencing analysis, which was then substantiated via Real-time quantitative PCR (RT-qPCR) and western blot tests. The influence of the WNT signaling on OSCC chemoresistance was ascertained through WNT3 knockdown or overexpression. The WNT inhibitor methyl 3-benzoate (MSAB) was probed for its capacity to boost 5FU efficacy.
Results
In this study, by constructing 5FU-resistant OSCC cell lines, the WNT/β-catenin signaling pathway was obviously activated in the drug-resistant cell lines through transcriptome sequencing analysis, RT-qPCR and western blot verification, and the key ligand for activation of the pathway, WNT3, was found. By knocking down WNT3 in resistant cells or overexpressing WNT3 in parental cells, we found that WNT3 promoted 5FU-resistance in OSCC. In addition, the WNT inhibitor MSAB reversed 5FU-resistance in OSCC cells.
Conclusions
These data underscored the activation of the WNT/β-catenin signaling pathway in resistant cells and identified the promoting effect of WNT3 upregulation on 5FU-resistance in oral squamous carcinoma. This may provide a new therapeutic strategy for reversing 5FU-resistance in OSCC cells.
Clinical Relevance
The clinical relevance of this study lies in providing a new therapeutic strategy for reversing 5FU-resistance in OSCC.
Glue embolization under inflow and outflow control by balloon occlusion for renal arteriovenous malformation treatment
Authors: Suzuki Tensei , Yamaguchi Hidenori , Kojima Mitsuaki , Kariyasu Toshiya , Nakamoto Raira , Nishikawa Makiko , Machida Haruhiko , Shoko Tomohisa 
Published: January 2024

Abstract
Background
Glue embolization under inflow and outflow control via balloon occlusion may allow successful embolization.
Case report
A 45-year-old woman presented with gross hematuria. Right renal arteriovenous malformation on abdominal contrast-enhanced computed tomography necessitated urgent transcatheter arterial embolization. Right renal digital subtraction angiography revealed a single tortuous and dilated vessel converging to an aneurysmal dilated vein. To selectively embolize the malformation, we closed the arterial side with a microballoon and attempted glue embolization; filling occurred unexpectedly early, and another balloon on the vein side helped control the renal vein blood flow. Glue embolization was performed without adverse events.
Conclusions
Glue embolization for high-flow arteriovenous malformation under balloon occlusion-mediated inflow and outflow control can effectively and safely embolize complete target vessels.
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in telomere length
Authors: Wang jia , Li Wen-wei , Qiu Zhi-kun 
Published: January 2024

Abstract

Background: There is ongoing controversy over the potential for telomere shortening caused by alcohol consumption and smoking. Therefore, the purpose of this study is to investigate the possibility of a relationship between telomere length and alcohol consumption or smoking.
Methods: To evaluate the causal relationship of smoking and alcohol consumption on telomere length, we conducted a bidirectional 2-sample Mendelian randomization (MR) analysis. Genetic associations of telomere length (n = 472,174) and lifetime smoking (n = 462,690) were obtained from UK Biobank datasets, and genetic associations of smoking initiation (n = 1,232,091), smoking cessation (n = 547,219), cigarettes per day (n = 337,334), and drinks per week (n = 941,280) were obtained from genome-wide association studies (GWAS) research. We used the inverse-variance weighted (IVW), weighted median, weighted mode, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and MR Egger regression methods to evaluate the association of genetically predicted exposure with the risk of outcome.
Results: MR demonstrated the higher risk of shorter telomere length was significantly associated with smoking initiation (β = -0.063, 95% confidence interview (CI): -0.082, -0.045, p < 0.05), smoking cessation (β = -0.1, 95%CI: -0.168, -0.032, p = 0.003), cigarettes per day (β = -0.05, 95%CI: -0.093, -0.007, p = 0.021), lifetime smoking (β = -0.182, 95%CI: -0.244, -0.121, p < 0.05), and drinks per week (β = -0.079, 95%CI: -0.143, -0.014, p = 0.016). But the reversal causality was not found.
Conclusion: Our results provide evidence of potential causal association of smoking and alcohol consumption on telomere length. It may contribute to the prevention of premature shortening of telomere length.