bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitoxic activity of spruce cone extract in acute lead acetate poisoning in experiment
Authors: Guljaev D. K. , Terehin G. A. , Semakin D. O. , Belonogova V. D. 
Published: December 2023

Introduction. Lead contamination is continuing worldwide. The development of new effective drugs for lead poisoning is an urgent task. The aim of the work is to evaluate the effectiveness of dry aqueous extract of spruce cones in lead poisoning. Materials and methods. The experiment was carried out on 24 white mongrel rats of both sexes. Animals of the studied groups were administered aqueous solution of lead acetate. The animals of the third group were treated with the extract of cones of common spruce (extract) by intragastric administration 3 times a week for a month. Animals of the fourth group were treated with polypheman by intragastric administration 3 times a week for a month. The elemental composition of tissue samples of animals of the studied groups was determined on energy dispersive X-ray fluorescence spectrometer QUANT’X. The free radical reaction with 2,2-diphenyl-1-picrylhydrazyl was used to determine the antioxidant activity of the extract. Results. In groups of animals injected with lead acetate solution and treated with the extract and the comparison preparation polyphepan, a decrease in lead content in bones and brain tissues was observed compared to the content in animals injected with lead acetate solution without treatment. No effect of the extract on the motor function of the intestine was revealed. When determining the antiradical activity, it was found that the extract showed a pronounced ability to bind free radicals, comparable to the known antioxidant rutin. Discussion. The use of the extract allows effective excretion of lead and prevents its deposition in bone tissue. Due to the ability of procyanidins to penetrate the blood-brain barrier, the extract is effective in brain damage caused by lead. The extract will also be effective in relieving oxidative stress resulting from lead poisoning. Conclusion. The dry aqueous extract of cones of common spruce shows the ability to reduce the lead content in bones and brain tissues in comparison with the group that did not receive treatment for lead acetate poisoning. The extract is able not only to effectively reduce the lead content in the body, but also to fight the consequences of poisoning, due to its pronounced antiradical activity.
Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments
Authors: Savateeva-Lyubimova T. N. , Sivak K. V. , Aleksandrov A. G. , Stosman K. I. 
Published: December 2023

Introduction. Gestational hypoxia plays an important role in fetal development, as it causes the development of oxidative stress and delayed psychomotor development. The aim of the study was to evaluate the prenatal effect of sodium nitrite on indices characterizing orienting and exploratory activity, mental activity and the degree of hypoxia in rat offspring. Materials and methods. Acute hypoxia was modeled by administration of sodium nitrite at a dose of 30 mg/kg intramuscularly to five pregnant rats during 16–19 days of gestation. Five females constituted a control group. In 50 born rats, orientation and exploration activity, cognitive functions, intensity of lipid peroxidation and glycolysis were studied. Results. The offspring of females that underwent acute hypoxia significantly lagged behind in the positive dynamics of body weight gain compared to control individuals. Thirty-day-old rats showed a pronounced disorder of the structure of behavioral pattern, learning process and long-term memory, increased content of diene conjugates, malonic dialdehyde and the level of lactate dehydrogenase activity in blood. Discussion. It was found that offspring whose mothers suffered acute hypoxia of toxic genesis developed pronounced behavioral disorders of psychomotor agitation and cognitive dysfunction characterized by decreased learning ability and impaired long-term memory. The content of primary and secondary products of lipid peroxidation and lactate dehydrogenase was increased in rats. The development of cellular oxidative stress under conditions of intrauterine hypoxia leads to oxygen deficiency in the fetus and a switch from tissue respiration to glycolysis, which underlies CNS damage. Conclusion. It was shown that sodium nitrite administration during the period from the 16th to the 19th day of gestation caused hyperactivity, depressed emotional status, and decreased orienting and exploratory activity and the ability to learn and retain a memory trace in rat offspring. Increased levels of diene conjugates and malonic dialdehyde, lactate dehydrogenase activity were observed in rats.
Liver macrophages as the key regulators of tissue homeostasis in organ
Authors: Sokolova K. V. , Danilova I. G. 
Published: December 2023

Introduction. View about hepatic macrophages as key regulators of tissue homeostasis, acting via innate and adaptive immune reactions, stimulated by exogenous and/or endogenous alarm signals of tissue injury or cell stress is substantiated in the review. From one hand, environmental signals determine macrophage polarization and production, but, on the other hand, macrophages affect tissue microenvironment and cells and tissue function at whole. The review was aimed to provide recent evidence of macrophage role in maintenance of tissue homeostasis in liver. Materials and Methods. Review is based on the 67 scientific articles, devoted to the study and analysis of macrophage role in the maintenance of tissue homeostasis in liver, found in PubMed database. Most of the analyzed articles (40 from 67) were published in 2017-2023. Results and Discussion. Information of origin and morpho-functional heterogeneity of hepatic macrophages was summarized in the review. Conclusion. The information presented in the review allow to conclude that macrophages are key regulators of homeostasis in the liver due to their ability to perceive many endogenous and exogenous signals in tissues and quickly respond to them in the direction of stabilizing the tissue microenvironment.
Mechanisms of development of postoperative pain syndrome in gynecological patients
Authors: Popov M. O. , Kinzhalova S. V. , Davydova N. S. , Sidenkova A. P. 
Published: December 2023

Introduction. Despite all the advances in anesthesiology, postoperative pain syndrome remains a serious problem. The lowest satisfaction with postoperative pain relief was found among gynecological patients. For adequate anesthesia and relief of postoperative pain syndrome in gynecological patients, a clear understanding of the features of pain development is necessary. The purpose of the study: identification of mechanisms of development of postoperative pain syndrome in gynecological patients. Materials and methods. The search and analysis of literature sources in the databases Scholar Google, Cyberleninka, PubMed, by keywords: physiology of pain, postoperative pain in gynecology, pain syndrome after uterine surgery. Criteria for the inclusion of articles: compliance with the subject of the review and the relevance of the data. The search depth was 33 years. The review includes 59 literary sources. Results. The development of pain syndrome is influenced by pathophysiological mechanisms, such as: the formation of hyperalgesia zones, changes in estrogen levels, damage to nerve fibers and genetic factors. To assess the level of pain, specialized scales are used, such as YOURS, CRH, DN4 scale. Psychological factors have a great influence on the formation of postoperative pain. Namely, the level of anxiety and depression, the level of catastrophization of pain, coping strategies used, psychological stability. Conclusion. Postoperative pain syndrome in gynecological patients is associated not only with the physiological mechanisms of pain development, but also with psychoemotional factors. A multidisciplinary approach is needed to alleviate pain in gynecological patients, including not only adequate multimodal anesthesia and analgesia in the perioperative period, but also collaboration with clinical psychologists, psychotherapists, to evaluate and possible selection of psycho-social therapy.
BİRİNCİ MECLİS’TE GENÇ MİLLETVEKİLLERİ VE MECLİS FAALİYETLERİ (1920-1923)
Authors: DİNÇER Burhan 
Published: December 2023

Bu çalışma, Türk parlamento tarihinde önemli bir yeri olan Birinci Meclis’te görev almış Genç milletvekillerinin özgeçmişlerini ve parlamentodaki çalışmalarını kapsamaktadır. Çalışma kapsamında, 1920-1923 yılları arasında Genç vilayetini temsil eden milletvekillerinin yerellik oranları, eğitim seviyeleri, mesleki durumları ve daha önceki parlamento tecrübesi gibi özellikleri dikkate alınarak milletvekillerinin bölgelerini ne ölçüde temsil ettikleri incelenmiştir. Bu bağlamda milletvekillerinin meclisteki çalışmaları ele alınarak temsil ettikleri bölgenin kalkınmasına ve ülke siyasetine olan katkıları ortaya konulmaya çalışılmıştır. Yasama dönemi boyunca Genç milletvekillerinin görev aldıkları komisyonlar, çeşitli konularda mecliste yaptıkları konuşmalar, vermiş oldukları takrir ve kanun teklifleri incelenerek parlamentodaki çalışmaları hakkında bilgi vermek amaçlanmaktadır.
Birinci Meclis’te, Genç vilayetini biri Son Osmanlı Mebusan Meclisi’nden gelen bir üyenin de katılmasıyla birlikte toplamda altı milletvekili temsil etmiştir. Bu çalışmanın ana konusunu 1920-1923 yılları arasında Birinci Meclis’te görev almış olan altı Genç milletvekillinin meclisteki çalışmaları oluştursa da konunun bütünlüğü açısından milletvekillerinin özgeçmişlerine de detaylı bir şekilde yer verilmiştir.
Belief in the Hereafter and Iqbal’s Concept of Eternity: An Analytical Study
Authors: Dr. Hafiz Arshid Iqbal  , Muhammad Jawad Abrar  , Dr. Hafiz Muhammad Abrar Awan  
Published: December 2023

Belief in the Hereafter is one of the six pillars of Islamic belief required of a Muslim in order to complete his faith. Although the general conception of life after death and the Hereafter is found in all Divine Religions, the emphasis given in Islam is unique. A glance at the Holy Quran provides the idea that believing in the Hereafter is the most important issue in Islam after believing in God. The topic has covered nearly one third of the Holy Quran with more than 1200 Ayaats. It is almost impossible to find a page in the Quran in which the issue of the Hereafter is not mentioned. Believing in God and the Hereafter are coupled in the Quran approximately 30 times. Therefore, in Islamic Theology, believing in God and the Hereafter are considered the border between atheism and religious belief. Believing in the Hereafter in Islam means the soul and the body of the dead will rise on the Day of Resurrection to be judged. Righteous people will be rewarded with eternal blessings in Paradise while the sinful and disbelievers will suffer in Hell, in following, arguments about hereafter along with Iqbal’s, critique on philosophers and concept of eternity would be discussed.
Research on David Hawkes’ English Translation of the Chu Ci from the Perspective of Thick Translation
Authors: Jiao Qianqian , Tian Chuanmao 
Published: December 2023

This paper firstly discusses the methods of thick translation in Hawkes’ translation which is characterized by the use of various paratexts. The paratexts in the translation belong to the peritext, including the preface, note on spelling, academic introductions, auxiliary illustrations, endnotes, and appendix. An analysis of the effects of the thick translation is made from the perspective of some translation reviews, average readers’ ratings, expert readers’ evaluations as well as library collections of the translation.
Nature-Culture Binary versus Ancient Folklore of Bihar (An Eastern Indian State)
Authors: Mallika Tosha , Dwivedi Rajiv Ranjan 
Published: December 2023

The research article utilizes the ancient folklore of Bihar to build an enhanced perspective on the relationship between culture and nature. Different legends, folk-beliefs, and folk practices have played an immense role in the generation of this analysis. The folklore of the Angika region as shown in the map is the primary source. The terms Angika and Ang Pradesh have both been famous in the ancient epic Mahabharata. Ang Pradesh is the abode of the warrior Karna, a prominent recurring figure in the epic. The researchers travelled to suburbs to interview the natives and document folklore. Whether nature culture could stagnantly be called binaries, is one of the central questions that the present research intends to answer.
Spor Yapan ve Yapmayan Üniversite Öğrencilerinin Sosyal Fizik Kaygı Düzeylerinin Araştırılması
Authors: MAÇÇA Esma , KALKAVAN Arslan , AKOĞUZ YAZICI Nihal 
Published: December 2023

Amaç: Çalışmamızın amacı, üniversite öğrencilerinin cinsiyetlerinin, yaşlarının, sınıflarının, spor yapma durumlarının ve spor dallarının sosyal fizik kaygısı üzerindeki etkilerini incelemektir.
Gereç ve Yöntem: Çalışmanın araştırma grubunu farklı bölümlerde öğrenim gören 413 öğrenci oluşturmuştur. Araştırmaya sadece gönüllü olarak katılmak isteyen öğrenciler dahil edilmiştir. Araştırma verilerinin toplanmasında kişisel bilgi formu ve Sosyal Fizik Kaygı Envanteri kullanılmıştır. Oluşturulan anket formu, örneklem grubuna yüz yüze anket yöntemi kullanılarak doldurtulmuştur. Normal dağıldığı tespit edilen verilerin analizinde iki grup için Bağımsız Gruplarda T-Testi, üç ve üzeri gruplarda Tek Yönlü Anova analizinden faydalanılmıştır.
Bulgular: Çalışmanın bulgularında cinsiyet, sınıf ve spor yapma durumu açısından sosyal fizik kaygısı düzeylerinde anlamlı fark olduğu görülürken (p0,05).
Sonuç: Sonuç olarak kadınların, 1. sınıfta okuyanların ve spor yapmayanların sosyal fizik kaygısının yüksek olduğu belirlendi. Çalışmamızda bu durum kadınların duyguları daha fazla yaşamaları, 1. sınıfta olanların ergenlik çağlarında olmaları ve spor yapmayanların ise hareketsiz olmalarından kaynaklı kendilerini beğenmeme durumu ile açıklanmıştır. Bu sonuçlar aktif yaşam açısından ele alındığında, sporun öğrencilerin sosyal-fiziksel kaygı düzeyleri üzerinde etkili olduğunu, diğer bir deyişle kaygılarını azalttığını göstermektedir.
A Review on Geographical and Pharmacological Distribution of Brassica Oleracea
Authors: Deepika Sati  , Deepika  , Bhatt Mansi , Kumar Roshan , Sood Prachi , Upadhyay Jyotsna , Naaz Farha , Nyarko Richard Owusu , Asum Christian 
Published: December 2023

Background: White cabbage, scientifically known as Brassica oleracea var. capitata f. alba, is a cruciferous vegetable that has long been valued for its culinary and medicinal uses. For the treatment of numerous illnesses, such as diabetes, cancer, inflammation, hypertension, hypercholesterolemia, bacteria, oxidation, and obesity, various preparations derived from various portions of the plant, including roots, shoots, leaves, and the entire plant, are utilized. Objective: Botany, distribution, traditional applications, phytochemistry, and pharmacological properties of B. oleracea var. capitata are all going to be assessed in this review. In addition, the gaps in knowledge will be filled and new research opportunities in pharmacology will be highlighted by this review. Method: Through an internet search of internationally recognised scientific databases, a variety of resources were gathered to gain a comprehensive understanding of Brassica oleracea var. capitata. These resources included research papers, reviews, books, and reports. Results: Alkaloids, flavonoids, organic acids, glucosinolates, steroids, hydrocarbons, and about forty-nine other phytochemical components of Brassica oleracea var. capitata have been culled from various sources. Bactericidal, antioxidant, anti-inflammatory, antibacterial, anti-obesity, anticoagulant, hepatoprotective, and anticancer are only a few of the pharmacological activities exhibited by crude extracts and phytoconstituents of Brassica oleracea var. capitata. Here you may find a complete inventory of the phytochemical components and pharmacological information pertaining to Brassica oleracea var. capitata. Conclusion: Results showed that Brassica oleracea var. capitata is a significant medicinal plant with multiple pharmacological effects, and the study also looked at its phytochemistry, traditional applications, and pharmacological activity. Our goal in conducting this assessment of this plant was to bridge knowledge gaps in the field and lay the groundwork for future studies and medication development. While researching Brassica oleracea var. capitata, we did find a number of significant traditional applications and pharmacological properties.
Residents’ Perceptions and Outcomes of Community-Based Tourism in Andro Village of Manipur
Authors: Ursa Thokchom , Arunkumar Moirangthem Cha 
Published: December 2023

Community-based Tourism (CBT) has various impacts on local communities in terms of socio-economic conditions, cultural heritage, environmental safeguards, and overall sustainable development of tourism in the long run. Sustainable development in tourism can be achieved through the independence of local communities and their active participation in tourism activities. Aiming to examine if there is any role of CBT in reaching sustainable goals for tourism, a case study that focuses on the social, economic, environmental and quality of life of the local community of Andro village in Manipur has been taken for study.
The result of the present study was able to indicate the occurrence of Community-Based Tourism in Andro village and it has been able to contribute to the overall sustainable development of the people and tourism activities. There have been diverse benefits to the local residents, which include job creation, local economic development, helping eco-friendly tourism development, community empowerment and preserving the unique cultural and traditional identity of the local community.
عیسمەت شەریف وانلی ڕۆڵی له‌ دامه‌زراندن و سه‌ركردایه‌تی كردنی كۆمه‌ڵه‌ی خوێندكارانی كورد له‌ ئه‌وروپا (KSSE)
Authors: ئیسماعیل محەمەد حەساف  , هاوكار كەریم حەمەشەریف  
Published: December 2023

ئەم توێژینەوەیە توێژینەوەیەكی زانستیی مێژووییە دەربارەی رۆڵی كەسایەتی عیسمەت شەریف وانلی لە سەركردایەتی و دامەزراندنی كۆمەڵەی خوێندكارانی كورد لە ئەوروپا KSSE. ئامانج لەم لێكۆڵینەوەیە سەرەڕای دیاركردنی ڕۆڵی عیسمەت شەریف وانلی لەم نێوەندەدا كۆكردنەوەی خوێندكارانی كورد لە ئەوروپا و لە بازنەیەكی ناسیۆنالیستیدا بەمەبەستی بە نێودەوڵەتی كردنی دۆزی سیاسی كورد بە كۆمەڵە و رێكخراوە نێودەوڵەتییەكان و نیشاندانی ئەو زوڵم و ستەمەی دەرهەق بەو نەتەوەیە ئەنجامدەدرێت لەلایەن هەر چوار دەوڵەتی كە پارچەیەك لە كوردستانیان داگیركردووە، ئەم لێكۆڵینەوەیە دابەش بووە بەسەر چەند ناونیشانێكی لاوەكی كە پێكهاتووە لە ژیاننامەی عیسمەت شەریف وانلی، خوێندنی لە سویسرا، ڕۆڵی لە دامەزراندن و سەركردایەتی كردنی كۆمەڵەی خوێندكارانی كورد لە ئەوروپا، ریزبەندیكردنی كۆنگرەكانی كۆمەڵەی خوێندكارانی كورد، لیستی سەرچاوەكان، ئەنجام، پوختە بەهەردوو زمانی عەرەبی و ئینگلیزی.
Die Jugendschule
Authors: Langner Anke , Wiechmann Katja 
Published: December 2023

Die Kulturhistorische Theorie charakterisiert die Entwicklung zwischen dem 12 und 14 Lebensjahr als Krise, in der sich die höheren psychischen Funktionen grundlegend neu ordnen. Im Rahmen dieser Umordnung wird es möglich und notwendig für das Individuum über sich selbst nachzudenken – sich selbst zu suchen. Die Entwicklung einer eigenen Identität rück in den Vordergrund für die einzelnen Schüler:innen und das schulische Lernen tritt in den Hintergrund, es wird für einige Schüler:innen zu einer kaum bewältigbaren Herausforderung. Im Rahmen dieses Beitrages soll diese Herausforderung beschrieben werden und ausgehend von dieser nach möglichen anderen Wegen in Schule gefragt werden. Mit dem Format der Jugendschule wird eine mögliche Antwort von Schule auf die Veränderungsprozesse bei den Schüler:innen formuliert. .
Many years of experience of spontaneous pneumothorax treatment within one medical center
Authors: Mikheev A. V. , Trushin S. N. 
Published: December 2023

The objective: to analyze results of surgical treatment of the patients with spontaneous pneumothorax.Subjects and Methods. Medical records of patients with spontaneous pneumothorax (SP) who were treated in Surgical Thoracic Department of Ryazan Regional Clinical Hospital from 1998 to 2021 were retrospectively analyzed. The article describes the experience of treatment of 738 cases of spontaneous pneumothorax within one medical center. The evolution of tactics and principles of surgical treatment over a 23-year period is presented. The incidence of spontaneous pneumothorax and efficacy of different surgical options were analyzed. The recurrence of spontaneous pneumothorax was recorded in the following cases: after pleural cavity drainage – in 19.7%, after videothoracoscopic resection of bullous parts of the lung in combination with subtotal parietal pleurectomy – in 2.1%.
Efficacy of Various Approaches to Treatment of Patients with Isoniazid Resistant Pulmonary Tuberculosis
Authors: Burmistrova I. A. , Vaniev E. V. , Samoylova A. G. , Lovacheva O. V. , Vasilyeva I. A. 
Published: December 2023

The objective: to evaluate the efficacy of chemotherapy regimens for isoniazid resistant pulmonary tuberculosis (Hr-TB): short-course regimen consisting of 4 components (non-injection) and the regimen consisting of 5 components (standard regimen).Subjects and Methods. Medical records of 292 pulmonary tuberculosis patients with resistance to isoniazid were retrospectively studied. In 89 patients (Group A), the regimen containing rifampicin, pyrazinamide, ethambutol, and levofloxacin was used – a 4-component non-injection regimen (180±20 doses). In 203 patients (Group B), the regimen containing rifampicin, pyrazinamide, ethambutol, levofloxacin, and amikacin/kanamycin was used - a 5-component standard regimen (270 doses).Results. The efficacy of treatment of isoniazid resistant pulmonary tuberculosis was similar, while a short-term 4-component (non-injection) regimen is 4.5 times less expensive versus the standard 5-component regimen. Treatment success made 88.8% and 88.2% respectively, p>0.05.