bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison Between Oral Dydrogesterone versus Intravaginal Micronized Progesterone Gel in Clinical Outcome within the First HRT-FET Cycle: A Retrospective Analysis
Authors: Ye Tian-Min , Luo Long-Dan , Huang Yuan-Fei , Ding Shufang 
Published: January 2024

Abstract
Objective
The purpose of this study is to compare the clinical efficacy of oral dydrogesterone and intravaginal micronized progesterone gel during the first HRT-FET cycle.
Methods
A retrospective cohort study based on a total of 344 women undergoing their first HRT-FET cycles without Gonadotropin-Releasing Hormone agonist (GnRH-a) pretreatment was conducted. All the cycles were allocated to two groups in the reproductive medical center at the University of Hong Kong-Shenzhen Hospital. One group (n = 193) received oral dydrogesterone 30mg/d before embryo transfer, while the other group (n = 151) received intravaginal micronized progesterone gel 180mg/d.
Results
The demographics and baseline characteristics of two groups were comparable. We found no statistically significant difference in live birth rate (24.35% vs. 31.13%, P = 0.16), clinical pregnancy rate (34.72% vs. 36.42%, P = 0.74), embryo implantation rate (25.09% vs. 28.36%, P = 0.43), positive pregnancy rate (42.49% vs 38.41%, P = 0.45), or ectopic pregnancy rate (0.52% vs. 0.66%, P = 0.86) between the oral dydrogesterone group and micronized vaginal progesterone (MVP) gel group. In the multivariate logistic regression analysis for covariates, medication used for luteal support was not associated with live birth rate (OR = 0.74, 95% CI: 0.46–1.21, P = 0.23). And the different luteal support medication did not have a significant positive association with the live birth rate in the cycles with day 2 embryo transferred (OR = 0.73, 95% CI:0.34–1.54, P = 0.41) and blastocyst transferred (OR = 0.75, 95% CI:0.36–1.57, P = 0.45).
Conclusion
This study demonstrates that oral dydrogesterone is a viable alternative to intravaginal micronized progesterone gel in luteal phase support (LPS) during the first HRT-FET cycle.
The effect of Baby-Friendly Hospital Initiative compliance on the association between the mode of birth and breastfeeding initiation in Sri Lanka
Authors: Lokeesan Laavanya , Martin Elizabeth , Byrne Rebecca , Miller Yvette 
Published: January 2024

Abstract

Background
In Sri Lanka, there is some evidence that the likelihood of breastfeeding initiation varies by exposure to Baby-Friendly Hospital Initiative [BFHI]-compliant care and mode of birth. Globally, there is some evidence that exposure to mother-baby skin-to-skin contact (BFHI Step 4) is lower in caesarean section births. Therefore, we aimed to determine how breastfeeding initiation varies by mode of birth in Sri Lanka, and the extent to which women’s exposure to BFHI practices practices explains any associations found.
Methods
A cross-sectional survey was conducted with women with a live baby across four government hospitals in Sri Lanka. Quantitative data were collected through participant interviews and extraction from medical records. Associations between BFHI practices, breastfeeding initiation, mode of birth, and women’s characteristics were assessed using binary logistic regression analysis applied in mediation and moderated mediation models.
Results
Women who received care compliant with Steps 4 and 6 of BFHI, regardless of their mode of birth, were more likely to initiate breastfeeding within the first hour after birth. BFHI Step 4 partially and completely mediated the effect of planned caesarean section and emergency caesarean section, respectively, on breastfeeding initiation within one hour of birth. Further, exposure to BFHI Step 6 partially mediated the effect of emergency caesarean section on breastfeeding initiation within one hour of birth. Women's age, pre-pregnancy BMI, parity status, and ethnic group, significantly influenced the relationship between planned or emergency caesarean section, exposure to Step 4 or Step 6 of BFHI, and breastfeeding initiation within one hour of birth. Specifically, being primiparous strengthened the likelihood that having a planned caesarean section decreased women's exposure to BFHI Step 4; and having a pre-pregnancy BMI categorized as overweight weakened the likelihood that planned caesarean section decreased exposure to BFHI Step 4.
Conclusions
Improving compliance with mother-baby skin-to-skin contact (BFHI Step 4) and no supplementation (BFHI Step 6) is critical for Sri Lankan health services to support all women to establish breastfeeding initiation within one hour of birth, as these practices attenuate the negative effect of caesarean sections on breastfeeding initiation.
Bamboo powders effectively reinforcing the modulus of PBAT composites and its reinforce mechanism
Authors: Ye Xiaojing , Ye Yanpeng , Han Yulong , Ren Fengmei , Ma Haihong , Xu Weibing , Zhou Zhengfa 
Published: January 2024

Abstract
Bamboo has a short growth cycle and exists in large quantities in nature. This paper uses bamboo powders (BP) to reinforce polybutylene adipate/terephthalate (PBAT) modulus. The BP was surface modified by γ-(2,3-epoxypropoxy)propyltrimethoxysilane (KH560), and compounded with PBAT in a twin-screw extruder. The results showed that the specific surface area and micropores of bamboo powders were considerably higher than that of common wood powders and cellulose. The tensile and flexural modulus of the composites increased 225% and 608%, respectively, when 25 wt% of modified bamboo powders (K-BP) was added, by comparing to that of pristine PBAT. The enhancement mechanism of K-BP was discussed, the large specific surface area and micropores of K-BP provided more anchoring sites, which effectively increased the interfacial binding force between K-BP and PBAT, and enhanced the nucleation ability of PBAT, thus improving the modulus of the composites. The results of this paper broadened the scope of application of PBAT.
The experiences and needs of older people receiving volunteer services in Chinese elderly care institutions: A qualitative study
Authors: Li Lin , Shen Qin , Wua Junxian 
Published: January 2024

Abstract

Background
Elderly people living in elderly institutions are eager to get volunteer help, but their satisfaction with volunteer services is not high. To better carry out volunteer services and improve the effectiveness of services, it is necessary to have a deep understanding of the real experience and needs of older people for volunteer services.
Methods
The purposive sampling method was used to select 14 older people from two elderly care institutions in Hangzhou and conduct semi-structured interviews. Collaizzi's seven-step method was used to analyze the data.
Results
Older people in nursing institutions have both positive and negative experiences in the process of accepting volunteer services; positive experiences include feeling the warmth of society and contributing to a better life, while negative experiences include the formalization of the service process, the lack of regularity in the frequency of services, and the mismatch between service supply and demand. The demand for volunteer services mainly focuses on emotional comfort, cultural entertainment, and knowledge learning.
Conclusion
Older people in elderly care institutions have varied volunteering experiences, and their volunteer demand is diversified. Volunteer service needs of older people should be accurately assessed, and volunteer service activities should be targeted.
Experience in the treatment of giant orbital intraconal teratoma: a case report
Authors: Li Ruimiao , Ren Mingyu , Wang Wenjing , Li Ruixin , Zhang Lili , Liu Limin 
Published: January 2024

Abstract
Background
Orbital teratoma is a relatively rare disease, often present at birth or detected within six months of life. As children are in the growth and development stage, giant orbital masses can affect orbital volumes, and conventional treatment may not be as effective as expected, with relatively many complications.
Case presentation:
A 2-year-old female child with proptosis, inwards, and upward eyeball displacement. Enhancing magnetic resonance imaging (MRI) revealed a well-circumscribed mass without significant improvement, which was hypointense signals on T1 weighted images(T1WI) and hyperintense signals on T2 weighted images(T2WI). A transconjunctival approach via the inferior fornix with canthotomy and cantholysis was performed. One month after surgery, the patient had enophthalmos, conjunctival hyperemia, and keratitis on ocular examination. A second operation was performed, with the implantation of an allogeneic sclera into the orbit to increase the orbital volume, improve the pitting of the fossa, and restore keratitis to normal. Histopathological examination showed that the fibrous capsule wall was covered with squamous and glandular epithelium, with visible brain tissue and cartilage-like matrix consistent with orbital teratoma.
Conclusions
Giant orbital teratomas in children are less common. This clinical case suggests that larger orbital masses occurring in childhood may result in markedly increased orbital volume and the possibility of postoperative enophthalmos and keratitis and that we need to increase the orbital volume and reduce the incidence of complications by timely implantation in orbit after excising the mass and defining its nature.
Neutrophil Extracellular Traps Formation: Effect of Leishmania major promastigotes and salivary gland homogenates of Phlebotomus papatasi in human neutrophil culture
Authors: Firouzjaie Fahimeh , Taghipour Niloofar , Akhavan Amir Ahmad , Tabaei Seyyed Javad Seyyed , Rouhani Soheila , Shirazian Maryam , Koochaki Ameneh , Fatemi Mahboubeh , Mossafa Nariman , Vaziri Vahideh Moin 
Published: January 2024

Abstract
Background
Leishmaniasis as a neglected tropical disease (NTD) is caused by the inoculation of Leishmania parasites via the bite of phlebotomine sand flies. After an infected bite, a series of innate and adaptive immune responses occurs, among which neutrophils can be mentioned as the initiators. Among the multiple functions of these fighting cells, neutrophil extracellular traps (NETs) were studied in the presence of Leishmania major promastigotes and salivary gland homogenates (SGH) of Phlebotomus papatasi alone, and in combination to mimic natural conditions of transmission.
Material & Methods
The effect of L. major and SGH on NETs formation was studied in three different groups: neutrophils + SGH (NS), neutrophils + L. major (NL), neutrophils + L. major + SGH (NLS) along with negative and positive controls in 2, 4 and 6 hours post-incubation. Different microscopic methods were used to visualize NETs comprising: fluorescence microscopy by Acridine Orange/ Ethidium Bromide staining, optical microscopy by Giemsa staining and scanning electron microscopy. In addition, the expression level of three different genes NE, MPO and MMP9 was evaluated by Real-Time PCR.
Results
All three microscopical methods revealed similar results, as in NS group, chromatin extrusion as a sign of NETosis, was not very evident in each three time points; but, in NL and especially NLS group, more NETosis was observed and the interaction between neutrophils and promastigotes in NL and also with saliva in NLS group, gradually increased over times. Real-time reveals that, the expression of MPO, NE and MMP9 genes increased during 2 and 4 hours after exposure, and then decreased at 6 hours in most groups.
Conclusion
Hence, it was determined that the simultaneous presence of parasite and saliva in NLS group has a greater impact on the formation of NETs compared to NL and NS groups.
The incidence of Acute Kidney Injury in preterm infants treated with early high dose caffeine
Authors: kasirer Yair , Schlesinger Noam , Tzvi-Behr Shimrit , Frishberg Yaacov , Ben-Shalom Efrat , Kasirer Yair 
Published: January 2024

Abstract

Background and Objectives
Acute kidney injury (AKI) is common in neonates and associated with increased morbidity and mortality, longer hospitalization, and a higher risk for future kidney damage. Caffeine treatment, commonly used to treat apnea of prematurity, was reported to be associated with decreased AKI occurrence. However, previous studies lack uniformity regarding the dosage and timing of the administration of the drug.
The objective of this study was to assess the incidence of AKI in VLBW preterm infants treated with early high dose caffeine, and to identify risk factors associated with AKI.
Methods
A retrospective cohort study of very low birth weight preterm infants admitted to the Neonatal Intensive Care Unit (NICU) at the Shaare Zedek Medical Center between Jan. 1, 2017 and Dec. 31, 2019. AKI was defined according to the neonatal AKI KDIGO classification, based on an elevation of serum creatinine levels or a decrease in urine output. High dose Caffeine (20 mg/kg bolus, administrated in the first hour of life, followed by a maintenance dose of 10 mg/kg/day) was universally administrated to all VLBW preterm infants born less than 32 weeks of gestation. Infants with inadequate data regarding urine output or less than two serum creatinine measurements were excluded.
Results
During the study period 311 VLBW infants were admitted, all had adequate serum creatinine and urine output data. 301 met the inclusion criteria, 41 infants (13.6%) were diagnosed with AKI, while only 12 (4%) during the first week of life, a significantly lower incidence in comparison to previous reports (p -value < 0.0001). Sixteen infants (5.1%) had more than one AKI episode. Seven infants (17%) had AKI stage 1 and 17 infants had stage 2 and 3 (41.5%).
AKI was associated with lower gestational age and male sex (p value = 0.002 and 0.03, respectively).
Conclusions
The incidence of AKI in a cohort of VLBW infants, treated with early high dose Caffeine was significantly lower as compared to previous studies, especially in the first week of life.
Spin practices and low reporting quality in studies on prediction model of diagnosis based on TCM information: A systematic review and evidence mapping
Authors: li Jieyun , Lin Jieqi , Xiao Xinang , Zhou Mi , Zhao-xia XU 
Published: January 2024

Abstract

Background Despite the abundance of published studies on prediction models for diagnosing Traditional Chinese medicine (TCM), there remains a lack of comprehensive assessment regarding reporting and methodological quality, as well as an absence of examination into the objectivity of linguistic aspects within these studies. Methods The PubMed, Cochrane Library, Web of Science, CNKI, VIP, and WANFANG databases were systematically searched from inception to October 30th, 2023, to identify studies developing and/or validating diagnostic and prognostic TCM prediction models using supervised machine learning. PROBAST and TRIPOD were employed to assess the reporting and methodological quality of identified studies. A previous article about spin in prognostic factor studies already identified several practices, which we modified for our data extraction The present study was registered on PROSPERO with the registration number CRD42023450907. Results 35 and 19 eligible studies published in Chinese and English were identified respectively from 1746 records. The clinical diseases with the most publications were diabetes (n = 7, 14.8%), coronary heart disease (n = 6, 11.1%), and lung cancer (n = 5, 9.26%). Primary analysis and sensitivity analysis confirmed that the reporting and methodological quality of included studies were correlated (rs= 0.504,p < 0.001). The quality of the CM prediction model requires improvement by including a structured title, participants and predictors selection, statistical analysis methods, model performance and interpretation. Two studies (4.55%) recommended the model to be used in daily practice lacked any external validation of the developed models. Six studies (13.63%) made recommendations for clinical use in their main text without any external validation. Reporting guidelines were only cited in one study (1.85%). Conclusion The available evidence indicated TCM information can provide predict information for different diseases, but the scientific quality of published studies needs to be improved.
Final results on effectiveness and safety of Ibrutinib in patients with chronic lymphocytic leukemia from the non-interventional FIRE study
Authors: DARTIGEAS Caroline , QUINQUENEL Anne , YSEBAERT Loïc , DILHUYDY Marie-Sarah , ANGLARET Bruno , SLAMA Borhane , DU Katell LE , TARDY Stéphanie , TCHERNONOG Emmanuelle , ORFEUVRE Hubert , VOILLAT Laurent , GUIDEZ Stéphanie , MALFUSON Jean-Valère , DUPUIS Sandrine , DESLANDES Marine , FEUGIER Pierre , LEBLOND Véronique 
Published: January 2024

Abstract
We conducted an observational study (FIRE) to understand the effectiveness and safety outcomes of ibrutinib in patients with chronic lymphocytic leukemia (CLL) in France, after a maximum follow-up of five years. Patients were included according to the French marketing authorization in 2016 (i.e. patients with relapsed or refractoryCLL or to previously untreated CLL patients with deletion 17p and/or TP53 mutations unsuitable for chemoimmunotherapy) and could have initiated ibrutinib more than 30 days prior their enrolment in the study (i.e. retrospective patients) or between 30 days before and 14 days after their enrolment (i.e. prospective patients). The results showed that in the effectiveness population (N=388), the median progression-free survival (PFS) was 53.1 (95% CI: 44.5-60.5) months for retrospective patients and 52.9 (95% CI: 40.3-60.6) months for prospective patients and no difference was shown between the PFS of patients who had at least one dose reduction versus the PFS of patients without dose reduction (p=0.7971 for retrospective and p=0.3163 for prospective patients). For both retrospective and prospective patients, the median overall survival was not reached. The most frequent treatment-emergent adverse event of interest was infections (57.6% retrospective; 71.4% prospective). A total of 14.6% of the retrospective patients and 22.4% of the prospective patients had an adverse event leading to death. Our findings on effectiveness were consistent with other studies and the fact that patients with dose reductions had similar PFS than patients without dose reduction is reassuring. No additional safety concerns than those already mentioned in previous studies could be noticed.
Trial registration
ClinicalTrials.gov, NCT03425591. Registered 1 February 2018 – Retrospectively registered.
Clinico–pathologic Factors and Survival of Patients with Breast Cancer Diagnosed with De Novo Brain Metastasis: A National Cancer Database Analysis
Authors: Hijazi Ali , Mohanna Mohamed , Sabbagh Saad , Montes Maria Jose Herran , Dominguez Barbara , Sarna Kaylee , Nahleh Zeina 
Published: January 2024

Abstract

Purpose
Patients with Breast Cancer (BC) with Brain Metastasis (BCBM) have poor survival outcomes. We aimed to explore the clinico–pathologic and therapeutic factors predicting the survival in patients with de novo BCBM using the National Cancer Database (NCDB).
Patients and Methods
The NCDB was queried for patients with BC between 2010–2020. Survival analysis with Kaplan–Meier curves and log rank tests were used to find median overall survival (OS) in months (95% CI) across the different variables. A multivariate cox regression model was computed to identify significant predictors of survival.
Results
Out of n=2,610,598 patients, n=9,005 (0.34%) had de novo BCBM. A trend of decreasing OS was observed with increasing age, Charlson–Deyo score (CDS), and number of extracranial metastatic sites. The highest median OS was observed in the Triple Positive and the lowest OS in the Triple Negative subgroup. Based on treatment regimen, combination of systemic therapy and local therapy achieved the highest OS. A positive trend in OS was observed in the BC subgroup analysis with targeted therapy demonstrating a survival benefit when added to systemic therapy.
The multivariate cox regression model showed that age, race, ethnicity, insurance, median income, facility type, CDS, BC subtype, metastatic location sites, and treatment combinations received were significantly associated with risk of death. Receiving only local treatment for BM without systemic therapy more than doubled the risk of death compared to combining it with systemic therapy.
Conclusions
This analysis suggests that treatment of systemic disease is the major factor influencing survival in patients with BCBM. Moreover, targeted therapy with anti–HER2 increased survival when added to systemic therapy explaining the highest median OS noted in the Triple Positive subgroup.
Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease
Authors: Bočková Martina , Vytvarova Eva , Lamoš Martin , Hlinka Jaroslav , Goldemundová Sabina , Rektor Ivan 
Published: January 2024

Abstract
The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions using the functional connectivity analysis in Parkinson’s disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased connectivity within subcortical regions and between subcortical and cortical motor regions in the high gamma band (50-100Hz) was significantly associated with the Movement Disorders Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III improvement. Further, the whole brain connectivity patterns were evaluated to complement this finding. The connectivity patterns in low gamma (30-50Hz) and high gamma band (50-100Hz) significantly correlated with the movement improvement. Neural correlates of cognitive performance were detected in the beta (12-30Hz) and high gamma (50-100Hz) bands. Finally, a whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to motor symptoms improvement after DBS and therapy responsiveness predictive connectivity profiles were uncovered.
Relationship between subtype-specific minimal residual disease level and long-term prognosis in children with acute lymphoblastic leukemia
Authors: 黄 筱彤 , Wang Chan-Juan , Gao Chao , Xue Tian-Lin , Zhao Zi-Jing , Wang Tian-You , Wu Min-Yuan , Cui Lei , Zhang Rui-Dong , Li Zhi-Gang 
Published: January 2024

Abstract
In childhood acute lymphoblastic leukemia (ALL), minimal residual disease (MRD) risk stratification criteria specific to common genetic subtypes are unclear. Among 723 children with newly diagnosed ALL treated with the Chinese Children Leukemia Group trial CCLG-2008 protocol, at time point 1 (TP1, the end of induction) and TP2 (before consolidation for standard risk and intermediate risk group, or before the second HR-I' block for high risk group), the MRD levels of children carrying different fusion genes or with T-ALL were significantly different (P all <0.001), and the prognostic significance of the same MRD level in the above subtypes was greatly different. For patients carrying BCR::ABL1 or KMT2A rearrangements, or ETV6::RUNX1, or with T-ALL, we defined those with both TP1 and TP2 MRD levels <10-2, TP1 MRD <10-3 and TP2 MRD-negative, TP1 MRD <10-3, as low MRD group respectively; the remaining children as high MRD group of each subtype. The 10-year relapse free survival (RFS) of low MRD group was significantly better than that of high MRD group. We verified the clinical value of the above MRD stratification criteria in patients treated with “Beijing Children’s Hospital BCH-ALL2003” protocol. In conclusion, subtype-specific MRD risk stratification may contribute to the precise treatment of childhood ALL.