bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management strategies to improve forage accumulation and nutritive value in crabgrass hayfields
Authors: Pedreira B. C. , Yasuoka J. I. , Barros I. T. M. D. , Helwig D. , Farney J. K. , Sassenrath G. F. 
Published: October 2023

AbstractCrabgrass (Digitaria spp.) is an annual summer grass capable of self-reseeding and can provide forage with high nutritive value. However, knowledge is still limited about crabgrass management. Our objective was to compare the forage accumulation (FA) and nutritive value of two crabgrass varieties (Mojo and Quick-N-Big) for 2 years under combinations of nitrogen rates and harvesting management. The experimental design was in randomized complete blocks with five treatments and three replications for each crabgrass variety, totalling 15 experimental units for Mojo and 15 for Quick-N-Big, in adjacent fields. Treatments were combinations of nitrogen rates (0, 112, and 224 kg N/ha) and harvest management (harvesting once or twice during the growing season). Nitrogen fertilization increased FA in Mojo and Quick-N-Big. The combination of two harvests and 224 kg N/ha (H2N224) resulted in a total forage accumulation (TFA) of 7840 kg DM/ha/yr for Mojo in 2020 and 8550 kg DM/ha/yr for Quick-N-Big in 2021. The H2N224 management also resulted in the highest crude protein (CP) accumulation. Nitrogen fertilization accelerates plant maturity, which can increase neutral detergent fibre (NDF). In this case, harvesting twice stimulates new tissue production, limits NDF and increases CP and total digestible nutrients (TDN). Therefore, increasing harvesting frequency (twice during the growing season) as N is input increases TFA, CP and TDN, and also enhances N recovery, which may contribute to reducing animal supplementation costs and improve the economic return of forage-based livestock systems.
Exploring sensory processing abilities in adults with acquired hearing loss
Authors: Tekin Dal Bilgehan , Çetin Binnur , Şimşek Eda Nur , Bumin Gonca 
Published: October 2023

AbstractObjectivesThis study aimed to evaluate the sensory processing abilities of adults with acquired hearing loss and determine whether their sensory processing patterns differ from those of the general population and adults with normal hearing.MethodThe study evaluated the sensory processing functions of 30 adults with acquired hearing loss using the Adolescent/Adult Sensory Profile and compared them with the sensory processing functions of 30 adults with normal hearing.ResultsThe results showed that individuals with hearing loss have a significantly higher sensitivity to stimuli related to motion, vision, activity and touch, exhibiting a low-registration sensory pattern and a sensation-avoiding pattern that differed from those of most individuals.ConclusionAssessing sensory processing profiles can help identify specific sensory difficulties and inform individualised treatment plans. The study highlights the importance of considering sensory processing patterns in the management of hearing loss to improve overall well-being and quality of life for adults with hearing loss.
Conceptual politics and resilience-at-work in the European Union
Authors: Joseph Jonathan , Juncos Ana E. 
Published: October 2023

AbstractInternational crises, most recently the Covid-19 pandemic and Russia’s invasion of Ukraine, often radically change our view of the world and our place within it. The European Union (EU) has been particularly impacted by these developments because these crises have accentuated some of its ontological and epistemological uncertainties and insecurities. While the EU’s resilience turn initiated by the EU Global Strategy of 2016 aimed at strengthening the EU’s ability to prepare and recover from external shocks and crises, since then, the concept of resilience has undergone a transformation. In recent years, we have seen the EU turning back in on itself and abandoning the radical aspects of resilience. Hence a paradox has emerged – the more complex the problems faced by the EU, the more it turns away from the logics of complexity present in the idea of resilience. In this article, we examine this conceptual shift through the lenses of concepts in action and the way these have reflected changes in the external context, but also power coalitions and institutional path dependencies. This argument will be explored by examining the recently adopted Strategic Compass and the EU’s Recovery and Resilience Facility (RRF).
A problem of Erdős–Graham–Granville–Selfridge on integral points on hyperelliptic curves
Authors: BUI HUNG M. , PRATT KYLE , ZAHARESCU ALEXANDRU 
Published: October 2023

AbstractErdős, Graham and Selfridge considered, for each positive integer n, the least value of
$t_n$
so that the integers
$n+1, n+2, \dots, n+t_n $
contain a subset the product of whose members with n is a square. An open problem posed by Granville concerns the size of
$t_n$
, under the assumption of the ABC conjecture. We establish some results on the distribution of
$t_n$
, and in the process solve Granville’s problem unconditionally.
Impact of Smart Glasses on Patient Care Time in Emergency Medical Services Ambulance
Authors: Apiratwarakul Korakot , Cheung Lap Woon , Ienghong Kamonwon 
Published: October 2023

AbstractIntroduction:The smart glasses were implemented as an innovative communication tool to enhance effectiveness in the field. The traditional mode of communication for Emergency Medical Services (EMS) was radio, which had significant restrictions, primarily that they were unable to transmit any visual data. To enhance efficiency, the smart glasses were used for a more accurate assessment of the condition of patients during transportation. At this time, however, no prior study has shown significant benefits of employing smart glasses into EMS.Study Objective:The primary objective of this study is to compare the duration of patient care in an ambulance between the use and non-use of smart glasses. The secondary objective is to identify the characteristics of data communication between the ambulance and the hospital.Methods:This retrospective study utilized data gathered from closed-circuit television (CCTV) in ambulances at Srinagarind Hospital, Thailand. The data were collected over a six-month period, specifically from July through December 2021. The study included two groups: the smart glasses group and no smart glasses groups, both used during EMS operations. The primary data collected focused on the duration of patient care in the ambulance. Additionally, the type and characteristics of data transfers via smart glasses during EMS operations were also recorded.Results:Out of the 256 EMS operations included in this study, 53.1% (N = 68) of the participants in the smart glasses group were male. The majority of operations were performed during the afternoon shift in both groups. The average patient care time in the smart glasses group was 10.07 minutes, while it was 5.10 minutes in the no smart glasses group (P <.001), indicating a significant difference. Visual data communication between the ambulance and the hospital via smart glasses predominantly involved vital signs (100.0%), physical examination (56.3%), and neurological examination (42.2%). The use of audio data from the hospital to the ambulance primarily included taking additional patient history (26.6%) and performing physical examinations (19.5%).Conclusion:The implementation of smart glasses in EMS operations resulted in an increase in patient care time in the ambulance. Furthermore, the use of smart glasses facilitated an effective channel of real-time two-way communication between the ambulance and the hospital.
A compact bent microstrip-based wideband millimeter wave MIMO antenna for 5G applications
Authors: Ali Ayyaz , Rasool Maryam , Zahid Zeeshan , Rashid Imran , Siddique Adil Masood , Maqsood Moazam , Bhatti Farooq Ahmed 
Published: October 2023

AbstractThis paper proposes a wideband four-element multiple-input multiple-output (MIMO) antenna operating in the millimeter-wave frequency band for 5G communications from 24.37–39.44 and 45.09–50.62 GHz. The antenna design has been realized using Rogers 5880 substrate and consists of a T-shaped strip that is attached to the top of a 50 Ω feeding line. Two microstrip lines are affixed at the terminal points of T-shaped strip and bent toward the feeding structure. These bent strip lines are then extended by joining two additional L-shaped microstrip lines. On the back, there is a partial defective ground plane featuring a rectangular slot and a thin strip line located at its center. The dimensions of the proposed single element and MIMO antenna are 0.933λ × 0.933λ × 0.024λ and 1.865λ × 1.865λ × 0.024λ, respectively (at 28 GHz), while the edge-to-edge distance between the radiation elements of the MIMO antenna is 4.0 mm. The design incorporates an efficient passive fan-shaped decoupling structure to decrease coupling between antenna elements. Simulations and experimental results show good agreement with each other. For all resonant frequencies the measured peak gain is greater than 4.85 dBi, radiation efficiency is over 90%, diversity gain is greater than 9.5, ECC is less than 0.025, TARC is less than -10 dB and CCL is below 0.4 bits/s/Hz. The proposed MIMO antenna, with its wide bandwidth, high gain, high inter-port isolation, and high efficiency characteristics, can be used for 5G wireless communication applications.
Adaptation of Family-Based Healthy Weight Program for Children Who Survived Leukemia
Authors: Jakubiak Jessica , Guan Megan , Khan Sabir , Fowler Lauren A. , Bates Carolyn R. , King Allison A. , Hayashi Robert J. , Fitzsimmons-Craft Ellen , Wilfley Denise E. 
Published: October 2023

Objective: Understand the perspectives of children who survived acute lymphoblastic leukemia (ALL) and their parents to adapt a guideline-based, family-based, intensive health behavior and lifestyle intervention treatment for this population. Method: Nine children 8–17 years of age ( Mdn = 12 years [interquartile range, 10–16], median years off treatment = 5 [2–7]) who survived ALL and 11 parents participated in focus groups to assess perceptions of weight, weight-related behaviors, and perceived barriers to family-based behavioral weight loss treatment (FBT). Responses were analyzed thematically, and resultant adaptations were guided by the Framework for Reporting Adaptations and Modifications-Enhanced. Results: Topics and themes identified included mental and physical health concerns (e.g., treatment-related medical complications, body esteem), a perception of excess weight as protective, the continuing influence of eating habits established during cancer treatment (e.g., instrumental feeding practices, snacking), and potential barriers to activity (i.e., physical limitations, lack of sport experience). Resultant adaptations to FBT were contextual (e.g., virtual delivery) and related to the content, including an emphasis on weight management in the context of survivorship; education about late effects, overweight and obesity; increased emphasis on structured eating patterns and instrumental eating; provider recommended physical activity; and tailored emotion-focused and body esteem content. Conclusions: Focus groups for children who survived pediatric ALL provided insights that aided the adaptation of FBT for this population. A pilot trial of FBT for children who survived ALL and their parents is underway to evaluate acceptability, feasibility, and preliminary efficacy. Implications for Impact Statement This study elicited perspectives of children who survived acute lymphoblastic leukemia and their parents to inform the adaptation of an intensive health behavior and lifestyle treatment for this population. The adaptation, which is delivered entirely virtually and includes an increased emphasis on emotion-focused content and structured and instrumental eating patterns, may offer a promising approach to decrease the risk for chronic, treatment-related medical complications within this population.
An “off-the-shelf” CD2 universal CAR-T therapy for T-cell malignancies
Authors: Xiang Jingyu , Devenport Jessica M. , Carter Alun J. , Staser Karl W. , Kim Miriam Y. , O’ Neal Julie , Ritchey Julie K. , Rettig Michael P. , Gao Feng , Rettig Garrett , Turk Rolf , Lee Byung Ha , Cooper Matthew L. , DiPersio John F. 
Published: October 2023

AbstractT-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic “universal” CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to prevent fratricide, and the T-cell receptor is removed to prevent GvHD. UCART2 demonstrated efficacy against T-ALL and CTCL and prolonged the survival of tumor-engrafted NSG mice in vivo. To evaluate the impact of CD2 on CAR-T function, we generated CD19 CAR-T cells (UCART19) with or without CD2 deletion, single-cell secretome analysis revealed that CD2 deletion in UCART19 reduced frequencies of the effector cytokines (Granzyme-B and IFN-γ). We also observed that UCART19ΔCD2 had reduced anti-tumor efficacy compared to UCART19 in a CD19+NALM6 xenograft model. Of note is that the reduced efficacy resulting from CD2 deletion was reversed when combined with rhIL-7-hyFc, a long-acting recombinant human interleukin-7. Treatment with rhIL-7-hyFc prolonged UCART2 persistence and increased survival in both the tumor re-challenge model and primary patient T-ALL model in vivo. Together, these data suggest that allogeneic fratricide-resistant UCART2, in combination with rhIL-7-hyFc, could be a suitable approach for treating T-cell malignancies.
ACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype
Authors: Shen Michelle , Liu Shiqin , Toland Angus , Hsu En-Chi , Hartono Alifiani B. , Alabi Busola R. , Aslan Merve , Nguyen Holly M. , Sessions Conner J. , Nolley Rosalie , Shi Chanjuan , Huang Jiaoti , Brooks James D. , Corey Eva , Stoyanova Tanya 
Published: October 2023

Abstract
Background
Neuroendocrine phenotype is commonly associated with therapy resistance and poor prognoses in small-cell neuroendocrine cancers (SCNCs), such as neuroendocrine prostate cancer (NEPC) and small-cell lung cancer (SCLC). Expression levels of current neuroendocrine markers exhibit high case-by-case variability, so multiple markers are used in combination to identify SCNCs. Here, we report that ACAA2 is elevated in SCNCs and is a potential molecular indicator for SCNCs.

Methods
ACAA2 expressions in tumour xenografts, tissue microarrays (TMAs), and patient tissues from prostate and lung cancers were analysed via immunohistochemistry. ACAA2 mRNA levels in lung and prostate cancer (PC) patients were assessed in published datasets.

Results
ACAA2 protein and mRNA levels were elevated in SCNCs relative to non-SCNCs. Medium/high ACAA2 intensity was observed in 78% of NEPC PDXs samples (N = 27) relative to 33% of adeno-CRPC (N = 86), 2% of localised PC (N = 50), and 0% of benign prostate specimens (N = 101). ACAA2 was also elevated in lung cancer patient tissues with neuroendocrine phenotype. 83% of lung carcinoid tissues (N = 12) and 90% of SCLC tissues (N = 10) exhibited medium/high intensity relative to 40% of lung adenocarcinoma (N = 15).

Conclusion
ACAA2 expression is elevated in aggressive SCNCs such as NEPC and SCLC, suggesting it is a potential molecular indicator for SCNCs.
Statistical laws of stick-slip friction at mesoscale
Authors: Yan Caishan , Chen Hsuan-Yi , Lai Pik-Yin , Tong Penger 
Published: October 2023

AbstractFriction between two rough solid surfaces often involves local stick-slip events occurring at different locations of the contact interface. If the apparent contact area is large, multiple local slips may take place simultaneously and the total frictional force is a sum of the pinning forces imposed by many asperities on the interface. Here, we report a systematic study of stick-slip friction over a mesoscale contact area using a hanging-beam lateral atomic-force-microscope, which is capable of resolving frictional force fluctuations generated by individual slip events and measuring their statistical properties at the single-slip resolution. The measured probability density functions (PDFs) of the slip length δxs, the maximal force Fc needed to trigger the local slips, and the local force gradient $${k}^{{\prime} }$$

k

′

of the asperity-induced pinning force field provide a comprehensive statistical description of stick-slip friction that is often associated with the avalanche dynamics at a critical state. In particular, the measured PDF of δxs obeys a power law distribution and the power-law exponent is explained by a new theoretical model for the under-damped spring-block motion under a Brownian-correlated pinning force field. This model provides a long-sought physical mechanism for the avalanche dynamics in stick-slip friction at mesoscale.
Fluorescent sensors for imaging of interstitial calcium
Authors: Valiente-Gabioud Ariel A. , Garteizgogeascoa Suñer Inés , Idziak Agata , Fabritius Arne , Basquin Jérome , Angibaud Julie , Nägerl U. Valentin , Singh Sumeet Pal , Griesbeck Oliver 
Published: October 2023

AbstractCalcium in interstitial fluids is central to systemic physiology and a crucial ion pool for entry into cells through numerous plasma membrane channels. Its study has been limited by the scarcity of methods that allow monitoring in tight inter-cell spaces of living tissues. Here we present high performance ultra-low affinity genetically encoded calcium biosensors named GreenT-ECs. GreenT-ECs combine large fluorescence changes upon calcium binding and binding affinities (Kds) ranging from 0.8 mM to 2.9 mM, making them tuned to calcium concentrations in extracellular organismal fluids. We validated GreenT-ECs in rodent hippocampal neurons and transgenic zebrafish in vivo, where the sensors enabled monitoring homeostatic regulation of tissue interstitial calcium. GreenT-ECs may become useful for recording very large calcium transients and for imaging calcium homeostasis in inter-cell structures in live tissues and organisms.
Closed-loop superconducting materials discovery
Authors: Pogue Elizabeth A. , New Alexander , McElroy Kyle , Le Nam Q. , Pekala Michael J. , McCue Ian , Gienger Eddie , Domenico Janna , Hedrick Elizabeth , McQueen Tyrel M. , Wilfong Brandon , Piatko Christine D. , Ratto Christopher R. , Lennon Andrew , Chung Christine , Montalbano Timothy , Bassen Gregory , Stiles Christopher D. 
Published: October 2023

AbstractDiscovery of novel materials is slow but necessary for societal progress. Here, we demonstrate a closed-loop machine learning (ML) approach to rapidly explore a large materials search space, accelerating the intentional discovery of superconducting compounds. By experimentally validating the results of the ML-generated superconductivity predictions and feeding those data back into the ML model to refine, we demonstrate that success rates for superconductor discovery can be more than doubled. Through four closed-loop cycles, we report discovery of a superconductor in the Zr-In-Ni system, re-discovery of five superconductors unknown in the training datasets, and identification of two additional phase diagrams of interest for new superconducting materials. Our work demonstrates the critical role experimental feedback provides in ML-driven discovery, and provides a blueprint for how to accelerate materials progress.
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Authors: Beaumont Robin N. , Flatley Christopher , Vaudel Marc , Wu Xiaoping , Chen Jing , Moen Gunn-Helen , Skotte Line , Helgeland Øyvind , Solé-Navais Pol , Banasik Karina , Albiñana Clara , Ronkainen Justiina , Fadista João , Stinson Sara Elizabeth , Trajanoska Katerina , Wang Carol A. , Westergaard David , Srinivasan Sundararajan , Sánchez-Soriano Carlos , Bilbao Jose Ramon , Allard Catherine , Groleau Marika , Kuulasmaa Teemu , Leirer Daniel J. , White Frédérique , Jacques Pierre-Étienne , Cheng Haoxiang , Hao Ke , Andreassen Ole A. , Åsvold Bjørn Olav , Atalay Mustafa , Bhatta Laxmi , Bouchard Luigi , Brumpton Ben Michael , Brunak Søren , Bybjerg-Grauholm Jonas , Ebbing Cathrine , Elliott Paul , Engelbrechtsen Line , Erikstrup Christian , Estarlich Marisa , Franks Stephen , Gaillard Romy , Geller Frank , Grove Jakob , Hougaard David M. , Kajantie Eero , Morgen Camilla S. , Nohr Ellen A. , Nyegaard Mette , Palmer Colin N. A. , Pedersen Ole Birger ,   The Early Growth Genetics (EGG) Consortium, Rivadeneira Fernando , Sebert Sylvain , Shields Beverley M. , Stoltenberg Camilla , Surakka Ida , Thørner Lise Wegner , Ullum Henrik , Vaarasmaki Marja , Vilhjalmsson Bjarni J. , Willer Cristen J. , Lakka Timo A. , Gybel-Brask Dorte , Bustamante Mariona , Hansen Torben , Pearson Ewan R. , Reynolds Rebecca M. , Ostrowski Sisse R. , Pennell Craig E. , Jaddoe Vincent W. V. , Felix Janine F. , Hattersley Andrew T. , Melbye Mads , Lawlor Deborah A. , Hveem Kristian , Werge Thomas , Nielsen Henriette Svarre , Magnus Per , Evans David M. , Jacobsson Bo , Järvelin Marjo-Riitta , Zhang Ge , Hivert Marie-France , Johansson Stefan , Freathy Rachel M. , Feenstra Bjarke , Njølstad Pål R. 
Published: October 2023

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
Re-evaluation of publicly available gene-expression databases using machine-learning yields a maximum prognostic power in breast cancer
Authors: Tschodu Dimitrij , Lippoldt Jürgen , Gottheil Pablo , Wegscheider Anne-Sophie , Käs Josef A. , Niendorf Axel 
Published: October 2023

AbstractGene expression signatures refer to patterns of gene activities and are used to classify different types of cancer, determine prognosis, and guide treatment decisions. Advancements in high-throughput technology and machine learning have led to improvements to predict a patient’s prognosis for different cancer phenotypes. However, computational methods for analyzing signatures have not been used to evaluate their prognostic power. Contention remains on the utility of gene expression signatures for prognosis. The prevalent approaches include random signatures, expert knowledge, and machine learning to construct an improved signature. We unify these approaches to evaluate their prognostic power. Re-evaluation of publicly available gene-expression data from 8 databases with 9 machine-learning models revealed previously unreported results. Gene-expression signatures are confirmed to be useful in predicting a patient’s prognosis. Convergent evidence from$$\approx$$≈ 10,000 signatures implicates a maximum prognostic power. By calculating the concordance index, which measures how well patients with different prognoses can be discriminated, we show that a signature can correctly discriminate patients’ prognoses no more than 80% of the time. Additionally, we show that more than 50% of the potentially available information is still missing at this value. We surmise that an accurate prognosis must incorporate molecular, clinical, histological, and other complementary factors.