bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premenstrual Syndrome: An Overview of the Review Analysis, and Potential Role of Herbal and Dietary Supplements
Authors: Kumari Pooja , Saxena  Pal Rashmi , Lalitha Chaitanya Motamarri Venkata Naga , Pal Yogendra , Punniyakotti Saranya 
Published: November 2023

:
A premenstrual syndrome is a group of regular physiological, mental, emotional, and
behavioral symptoms that appear periodically in the luteal phase of the menstrual cycle, and they
vanish quickly with the beginning of menstruation or a few days afterward. Thus, severe premenstrual
syndrome (PMS) affects 5–8% of women; the majority of these individuals also match the
factors for premenstrual dysphoric disorder (PMDD). Premenstrual syndrome typically includes
physical problems like headache, tiredness, indigestion, insomnia, nausea, and breast tenderness
as well as symptoms associated with emotions (mood swings, anxiousness, and aggressiveness).
Although the true mechanism of PMS is unknown, a number of theories point to increased sensitivity
to typical hormonal changes and imbalances in neurotransmitters. A multidisciplinary team
using an integrative holistic approach in the direction of an individualized strategy gradually manages
PMS. The first phase entails educating women about PMS, self-screening, herbs like St John’s
Wort, chaste berry, saffron; ginkgo biloba; chamomile, evening primrose, turmeric and so on,
various nutrition supplements as Vitamin B6; calcium; magnesium and lifestyle adjustments like
dietary modifications; exercise; yoga; sleep hygiene. The second step involves implementing various
relaxation therapies, cognitive behavioral therapy (CBT), stress reduction techniques, and
acupuncture. The available treatment as various drugs like SSRIs; serotonergic antidepressants;
anxiolytics and hormonal therapy that are used currently to treat PMS, exhibits unwanted side effects.
Therefore, this issue and other similar gynecological conditions have been discussed and managed
with herbal medicines and other natural solutions in this comprehensive piece of work.
Diagnosis of Benign and Malignant BI-RADS 4 Breast Masses by Contrastenhanced
Ultrasound Combined with Shear Wave Elastography
Authors: Weng Lifeng , Yu Mengxia 
Published: November 2023

Background::
Breast cancer, one of the most prevalent malignant tumors in females, usually occurs in the breast epithelial tissues.

Objective::
The study aimed to explore the diagnostic value of contrast-enhanced ultrasound (CEUS) combined with shear wave elastography (SWE) in the
diagnosis of benign and malignant breast masses in BI-RADS (Breast Imaging Reporting and Data System) 4.

Methods::
Examination outcomes and clinical information of 83 patients with BI-RADS 4 breast masses were analyzed retrospectively. These included
patients who received CEUS, SWE, and pathological examinations. The difference of CEUS in determining the classification of BI-RADS 4 breast
masses was evaluated using histopathological outcomes of breast masses as a reference standard. The diagnostic value of CEUS, SWE, and CEUS
combined with SWE in the diagnosis of benign and malignant breast masses in BI-RADS 4 was also explored.

Results::
Pathological biopsy results revealed 63 malignant masses and 20 benign masses among 83 BI-RADS 4 breast masses, with a 75.9% incidence of
malignant masses. After the diagnosis of BI-RADS 4 breast masses with CEUS, SWE, and CEUS+SWE, the incidence of malignancy was 56.6%,
78.3%, and 73.5%, respectively. CEUS+SWE showed higher sensitivity (93.7% vs. 81% and 68.3%), specificity (90% vs. 30% and 80%), positive
predictive value (96.7% vs. 78.5% and 91.5%), negative predictive value (81.8% vs. 33.3% and 44.4%), and diagnostic coincidence rate (92.8% vs.
68.7% and 71.1%) than SWE and CEUS alone in diagnosing pathological type of breast masses. Moreover, CEUS combined with SWE exhibited a
larger area under the receiver operating characteristic (ROC) curve (0.918) than SWE (0.741, p = 0.028) and CEUS (0.555, p < 0.001) alone in the
diagnosis of BI-RADS 4 breast masses.

Conclusion::
Overall, the diagnostic value of CEUS+SWE for the pathological type of BI-RADS is preferred over CEUS and SWE alone. CEUS+SWE showed
higher values than CEUS and SWE alone in diagnosing BI-RADS 4 breast masses. Specifically, CEUS+SWE can correctly identify benign and
malignant masses, reduce unnecessary trauma, and avoid misdiagnosis. In summary, CEUS combined with SWE can serve as an effective
diagnostic method and avoid delaying the best treatment opportunity for some malignant lesions.
Ultrasound-based Radiomics for Predicting Metastasis in the Lymph Nodes
Posterior to the Right Recurrent Laryngeal Nerve in Patients with Papillary
Thyroid Cancer
Authors: Shen Bo , Zhou Chao , Xu Chaoli , Yang Bin , Wu Xiaoman , Fu Xiaodan , Liu Siyue , Sun Jiaying , Xie Yingdong , Zhu Zheng 
Published: November 2023

Background::
Dissection of the lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLNs) in papillary thyroid cancer (PTC) remains
controversial.

Objective::
This study aimed to determine the capability of ultrasonography (US)-based radiomics for presurgical prediction of metastasis in LN-prRLNs in
PTC.

Methods::
Patients were retrospectively enrolled and pathologically confirmed as LN-prRLN metastasis with PTC after surgery. Radiomic analysis based on
preoperative US images with manual segmentation of targets was used to develop a radiomics model. US features described in ACR TI-RADS
were collected to construct a clinical model. The Radiomics model, a combined model integrating radiomics and clinical model, was also
developed for the presurgical prediction of metastasis in LN-prRLNs.

Results::
A total of 570 patients, including 488 patients with non-LN-prRLN metastasis and 82 with LN-prRLN metastasis, were assessed. The 15 topperforming
features finally remained significant for constructing the radiomics model. The combined model showed that US measured tumor size
(OR: 1.036, P = 0.044), US suspected lateral lymph node metastasis (OR: 2.247, P = 0.009), multifocality (OR: 1.920, P = 0.021), Delphian lymph
node metastasis (DLNM) (OR: 2.300, P = 0.039), VIa compartment metastasis (OR: 5.357, P = 0.000), the radiomics score (OR: 1.003, P = 0.001)
were significant risk factors for predicting LN-prRLN metastasis. The combined model achieved a higher AUC of 0.849 than that of the clinical
model (AUC: 0.759) and radiomics model (AUC: 0.826).

Conclusion::
The US-based radiomics combined model can more effectively predict LN-prRLN metastasis in PTCs patients preoperatively. This approach had
the potential to assist surgeons indecision-making regarding LN-prRLN dissection.
Radial Endobronchial Ultrasound-guided Transbronchial Cryobiopsy versus Forceps Biopsy for the Diagnosis of Solitary Pulmonary Nodules: A Prospective Randomised Trial
Authors: Brown Michael , Nguyen Phan , Jersmann Hubertus , Holmes Mark , Wong Michelle 
Published: November 2023

Background:
Improvements in pulmonary diagnostic imaging and the development of lung cancer screening are increasing the prevalence of Solitary pulmonary nodules (SPNs). Fluoroscopically guided radial endobronchial ultrasound (EBUS) with transbronchial forceps biopsy (TB-FB) has been the conventional diagnostic method. Transbronchial cryobiopsy (TB-CB) is an alternative biopsy method. We sought to compare transbronchial cryobiopsy to transbronchial forceps biopsy for the diagnosis of SPNs.

Methods:
A prospective, single-centre, randomised controlled trial was conducted at the Royal Adelaide Hospital (RAH). Patients with SPNs were randomised to either 5 transbronchial forceps biopsies or one transbronchial cryobiopsy. Complete blinding of investigators and participants was not possible, as transbronchial cryobiopsy required general anaesthesia. The primary outcome was diagnostic yield with secondary outcomes of specimen size, diagnostic yield for subsets challenging to access with forceps and safety.

Results:
The overall diagnostic yield for the 28 enrolled subjects was 76.8%(22/28). The diagnostic yield was 91.7% (11/12 patients) for transbronchial cryobiopsy and 68.8% (11/16 patients) for forceps biopsy (p=0.14). Median biopsy sizes were consistently larger for the cryobiopsy arm at 7.0mm compared to 2.5mm(p<0.0001). An eccentric EBUS image signalling the probe was adjacent to the nodule occurred in 4/28 cases, and TB-CB confirmed a diagnosis in 3/3 randomised to this arm. There were no major complications with either technique.

Conclusion:
Transbronchial cryobiopsy under the guidance of fluoroscopy and radial EBUS facilitates larger biopsy specimens without a significant increase in major complications. Further research is required to confirm the effect on diagnostic yield; however, our study supports a role for TB-CB in the diagnosis of SPNs and small, nodule-adjacent biopsies.

Clinical Trial Registration Number:
Reference number of R20160213(HREC/16/RAH/37).
A Critical Study on the Synthetic and Herbal Medication Pattern in the
Management of Psoriasis
Authors: Chandel Shobhini , Das Saumya , Neha Neha , Chauhan Vijayant Singh 
Published: November 2023

Abstract::
Psoriasis is a persistent skin illness that causes dense, shimmering flakes, irritable,
dry, and red patches as a result of the fast buildup of skin cells. It is an autoimmune skin condition
that is incurable, non-contagious, and relapsing-remitting. Typically, a remission phase lasts
one to twelve months. Psoriasis is caused by a number of cellular mechanisms, and it has been
hypothesised that T lymphocytes, keratinocytes, allergen cells, Langerhans cells, natural killer
cells, phagocytes, a number of Th1-type chemokines, in addition to growth factors like
endothelial proliferation factor and keratinocytes growth factor, among others, are key players in
the development of psoriasis. Numerous synthetic medicinal drugs have been documented to
have the side effects of psoriasis. Due to the safety and accessibility, herbal medications may
hold promise as possible anti-psoriatic molecules. Before creating a potential herbal drug, it is
important to thoroughly examine the key players in the evolution of psoriasis, such as T-cell
stimulation, transportation, and cytokinase inhibition. The purpose of this review is to investigate
how psoriasis spreads and becomes activated, as well as how certain medications might
exacerbate the condition and how certain plant resources may be used to treat psoriasis. To
create a potent, secure, and dependable treatment, more scientific research on these herbal
resources is required.
Bridge Frost Prediction Using K-nearest Neighbor Classifier
Authors: Jang Jinhwan 
Published: November 2023

Background:
Considering the frequent occurrence of accidents on icy bridges during winter nights, it would be advantageous to notify both road managers and drivers regarding the most perilous areas. This notification would allow road managers to address the icy conditions by applying de-icing substances, while drivers could be more adequately prepared for potential hazards.

Methods:
In this study, the focus was on investigating k-nearest neighbor algorithms to predict nighttime icing caused by frost on three distinct bridges located on the National Highways in Korea. The algorithms utilized atmospheric data as input, which was obtained from the weather agency's website through an open API. The input data included relative humidity, air temperature, and dew point temperature, as well as the disparities in air temperature and humidity between two consecutive days.

Results:
In order to assess the effectiveness of the prediction models, reference data were created using the fundamental principle that ice is formed when the temperature of the pavement is below freezing and lower than the dew point temperature. Consequently, the developed algorithm demonstrated favorable performance, achieving an accuracy of 95% when evaluated using a test dataset that occupies 30% of the entire data.

Conclusion:
Considering the increasing focus on preventive maintenance, these newly developed forecasting models can be employed proactively as a preventive measure against icing. This proactive approach will ultimately contribute to improving traffic safety on winter roads.
Exploring the Mechanism of Brucea Javanica against Ovarian Cancer based on Network Pharmacology and the Influence of Luteolin on the PI3K/AKT Pathway
Authors: Zhu Jufan , Han Mengfei , Yang Yiheng , Feng Renqian , Hu Yan , Wang Yuli 
Published: November 2023

Background:
Ovarian cancer (OC) is a commonly diagnosed female cancer around the
world. The Chinese herbal medicine Brucea javanica has an anti-cancer effect. However, there is
no relevant report on whether Brucea javanica is effective in treating OC, and the corresponding
mechanism is also unknown.

Objective:
This study was projected to excavate the active components and underpinned molecular
mechanisms of Brucea javanica in treating ovarian cancer (OC) through network pharmacology
combined with in vitro experiments.

Methods:
The essential active components of Brucea javanica were selected using the TCMSP
database. The OC-related targets were selected by GeneCards, intersecting targets were obtained
by Venn Diagram. The core targets were obtained through the PPI network and Cytoscape, and the
key pathway was gained through GO and KEGG enrichment analyses. Meanwhile, docking conformation
was observed as reflected by molecular docking. MTT, colony formation assay and flow
cytometer (FCM) analysis were performed to determine cell proliferation and apoptosis, respectively.
Finally, Levels of various signaling proteins were evaluated by western blotting.

Results:
Luteolin, β-sitosterol and their corresponding targets were selected as the essential active
components of Brucea javanica. 76 intersecting targets were obtained by Venn Diagram. TP53,
AKT1, and TNF were obtained through the PPI network and Cytoscape, and the key pathway
PI3K/AKT was gained through GO and KEGG enrichment analyses. A good docking conformation
was observed between luteolin and AKT1. Luteolin could hinder A2780 cell proliferation,
induce cell apoptosis and enhance the inhibition of the PI3K/AKT pathway.

Conclusion:
It was verified in vitro that luteolin could hinder OC cell proliferation and activate the
PI3K/AKT pathway to lead to apoptosis.
Use of Epic Electronic Health Record System for Health Care Research: Scoping Review
Authors: Chishtie Jawad , Sapiro Natalie , Wiebe Natalie , Rabatach Leora , Lorenzetti Diane , Leung Alexander A , Rabi Doreen , Quan Hude , Eastwood Cathy A 
Published: November 2023

Background
Electronic health records (EHRs) enable health data exchange across interconnected systems from varied settings. Epic is among the 5 leading EHR providers and is the most adopted EHR system across the globe. Despite its global reach, there is a gap in the literature detailing how EHR systems such as Epic have been used for health care research.

Objective
The objective of this scoping review is to synthesize the available literature on use cases of the Epic EHR for research in various areas of clinical and health sciences.

Methods
We used established scoping review methods and searched 9 major information repositories, including databases and gray literature sources. To categorize the research data, we developed detailed criteria for 5 major research domains to present the results.

Results
We present a comprehensive picture of the method types in 5 research domains. A total of 4669 articles were screened by 2 independent reviewers at each stage, while 206 articles were abstracted. Most studies were from the United States, with a sharp increase in volume from the year 2015 onwards. Most articles focused on clinical care, health services research and clinical decision support. Among research designs, most studies used longitudinal designs, followed by interventional studies implemented at single sites in adult populations. Important facilitators and barriers to the use of Epic and EHRs in general were identified. Important lessons to the use of Epic and other EHRs for research purposes were also synthesized.

Conclusions
The Epic EHR provides a wide variety of functions that are helpful toward research in several domains, including clinical and population health, quality improvement, and the development of clinical decision support tools. As Epic is reported to be the most globally adopted EHR, researchers can take advantage of its various system features, including pooled data, integration of modules and developing decision support tools. Such research opportunities afforded by the system can contribute to improving quality of care, building health system efficiencies, and conducting population-level studies. Although this review is limited to the Epic EHR system, the larger lessons are generalizable to other EHRs.
THE FOUR FACTORS DOMINATING ONLINE STREAMING PLATFORMS AS WITNESSED BY NETFLIX IN THE WAKE OF GLOBALIZATION
Authors: Sekartaji Swelana 
Published: November 2023

The globalization process has increased everything's accessibility and connectivity. Through information and technology, globalization makes it easier to move products, services, cultures, innovations, and creative ideas. As one of the most popular online streaming services, Netflix is fostering cross-cultural exchanges as part of the increasing globalization of capitalism. The author uses written sources, information, and evidence in the form of quotes from written works, written papers, and written responses to articles, reports, publications, and statistical data that are pertinent to Netflix. The author will apply globalization theory and a transnational approach to investigate why individuals favor Netflix over alternative online streaming services. These two theories are implemented in elaborating four dominant factors that Netflix has influenced the new habit patterns in today's society. Market growth will always play a role in globalization-related economic and cultural activities and processes. As a result, four key elements affect Netflix’s market dominance: substitution, barriers to entry and potential competition, measures of profitability, and market share.
Regional Citrate Anticoagulation versus No Anticoagulation for CKRT in Patients with Liver Failure with Increased Bleeding Risk
Authors: Bai Ming , Yu Yan , Zhao Lijuan , Tian Xiujuan , Zhou Meilan , Jiao Jing , Liu Yi , Li Yajuan , Yue Yuan , Wei Lei , Jing Rui , Li Yangping , Ma Feng , Liang Ying , Sun Shiren 
Published: November 2023

Background
The opinions on the efficacy and safety of no anticoagulation versus regional citrate anticoagulation for continuous KRT (CKRT) were controversial in patients with severe liver failure with a higher bleeding risk. We performed a randomized controlled trial to assess no anticoagulation versus regional citrate anticoagulation for CKRT in these patients.

Methods
Adult patients with liver failure with a higher bleeding risk who required CKRT were considered candidates. The included participants were randomized to receive regional citrate anticoagulation or no-anticoagulation CKRT. The primary end point was filter failure.

Results
Of the included participants, 44 and 45 were randomized to receive regional citrate anticoagulation and no-anticoagulation CKRT, respectively. The no-anticoagulation group had a significantly higher filter failure rate (25 [56%] versus 12 [27%], P = 0.003), which was confirmed by cumulative incidence function analysis and sensitive analysis including only the first CKRT sessions. In the cumulative incidence function analysis, the cumulative filter failure rates at 24, 48, and 72 hours of the no-anticoagulation and regional citrate anticoagulation groups were 31%, 58%, and 76% and 11%, 23%, and 35%, respectively. Participants in the regional citrate anticoagulation group had significantly higher incidences of Ca2+
tot/Ca2+
ion >2.5 (7% versus 57%, P < 0.001), hypocalcemia (51% versus 82%, P = 0.002), and severe hypocalcemia (13% versus 77%, P < 0.001). However, most (73%) of the increased Ca2+
tot/Ca2+
ion ratios were normalized after the upregulation of the calcium substitution rate. In the regional citrate anticoagulation group, there was no significant additional increase in the systemic citrate concentration after 6 hours.

Conclusions
For patients with liver failure with a higher bleeding risk who required CKRT, regional citrate anticoagulation resulted in significantly longer filter lifespan than no anticoagulation. However, regional citrate anticoagulation in patients with liver failure was associated with a significantly higher risk of hypocalcemia, severe hypocalcemia, and Ca2+
tot/Ca2+
ion >2.5.

Clinical Trial registry name and registration number
RCA for CRRT in Liver Failure and High Risk Bleeding Patients, NCT03791190.
PEMERIKSAAN PROFIL LIPID PADA JEMAAT LANSIA SALAH SATU GEREJA KRISTEN DI YOGYAKARTA
Authors: Patramurti Christine , Triwulandari Erna , Nastiti Christofori Maria Ratna Rini 
Published: November 2023

Lipid profile examination including total cholesterol level, triglycerides level and high-density lipoprotein cholesterol reduction is essential to be done as a routine activity quinquennially to prevent someone from the risk of cardiovascular diseases, diabetes and obesity. This kind of examination is mandatory for the elderly people to maintain their quality of life. In order to support the government program on the prevention of the cardiovascular diseases, a team of social service of Faculty of Pharmacy Universitas Sanata Dharma (FFUSD) was organizing an event of lipid profile examination in one of Christian church located in Kalasan, Yogyakarta. As many as 35 elderly people were enthusiastically participating on the event. A nurse from Poliklinik Sanata Dharma was appointed to take the blood samples, which were further taken to the Biochemistry Laboratory in FFUSD to get analysed. The results were sent to the participants in private. The overall blood lipid profiles of most participants showed good level of quality, indicating that they have been trying to manage their life healthily. However, as much as 62. 8% of participants showed a low level of the high-density lipoprotein cholesterol. This was believed due to the food intake which was still rich in oil and fat. The event was very succesful and the responses were very positive. The participants felt assisted with a fast and accurate results sent.
PENDIDIKAN KARAKTER PERSPEKTIF HADITS
Authors: Jannah Sitti Riadil 
Published: November 2023

Basically, education is not just a process of transferring knowledge in the cognitive dimension from educators to students but much deeper than that education must be able to empower students in other dimensions, namely the psychomotor dimension or affective dimension. The concept of character education (affective dimension) of interest to be developed of how the concept of character education in the perspective of the hadith and its relevance to the concept of character education in the contemporary era with reference to the hadith of the concept of character education when the fetus is still in the womb and the concept of character education in the stages of child development after birth.
Hadith's understanding of the concept of character education, when the fetus is still in the womb, showed the provisions of Allah. the child while still in the womb of his mother who in this case is sex, death, and sustenance indicates that the child already has the potential to receive influence from the outside so that children who are still in the womb of need to continue to be treated with the values ​​of character education through various way to keep emotions in order to remain stable mom, eat kosher food, listen to the recitation of the Koran or the moral worth of music, and the like.
Understanding the hadith about the concept of character education in the stages of child development after birth showed that the phases of the order of prayer in children begin with the command at age 7 years ago with a punch at the age of 10 years if they do not want to do give clues about the stages of character education, time, and objects formal and material that needs to be applied in accordance with the concept of education for the contemporary era.