bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating the glucose‐lowering effect of the bile acid sequestrant sevelamer
Authors: Nerild Henriette H. , Brønden Andreas , Haddouchi Abdullah E. , Ellegaard Anne‐Marie , Hartmann Bolette , Rehfeld Jens F. , Holst Jens J. , Sonne David P. , Vilsbøll Tina , Knop Filip K. 
Published: December 2023

AbstractAim: Bile acid sequestrants are cholesterol‐lowering drugs, which also improve glycaemic control in people with type 2 diabetes. The mechanism behind the glucose‐lowering effect is unknown but has been proposed to be mediated by increased glucagon‐like peptide‐1 (GLP‐1) secretion. Here, we investigated the glucose‐lowering effects of sevelamer including any contribution from GLP‐1 in people with type 2 diabetes.Materials and Methods: In a randomized, double‐blind, placebo‐controlled, crossover study, 15 people with type 2 diabetes on metformin monotherapy underwent two 17‐day treatment periods with the bile acid sequestrant sevelamer and placebo, respectively, in a randomized order and with an interposed wash‐out period of minimum 6 weeks. On days 15 and 17 of each treatment period, participants underwent experimental days with 4‐h liquid meal tests and application of concomitant infusion of exendin(9‐39)NH2 or saline.Results: Compared with placebo, sevelamer improved insulin sensitivity (assessed by homeostatic model assessment of insulin resistance) and beta‐cell sensitivity to glucose and lowered fasting and postprandial plasma glucose concentrations. In both treatment periods, exendin(9‐39)NH2 increased postprandial glucose excursions compared with saline but without absolute or relative difference between the two treatment periods. In contrast, exendin(9‐39)NH2 abolished the sevelamer‐induced improvement in beta‐cell glucose sensitivity.Conclusions: The bile acid sequestrant sevelamer improved insulin sensitivity and beta‐cell sensitivity to glucose, but using the GLP‐1 receptor antagonist exendin(9‐39)NH2 we were not able to detect a GLP‐1‐mediated glucose‐lowering effect of sevelamer in individuals with type 2 diabetes. Nevertheless, the sevelamer‐induced improvement of beta‐cell sensitivity to glucose was shown to be GLP‐1‐dependent.
Temperature effect on mode I fracture toughness of silica/glass/epoxy composites
Authors: Ardakani‐Movaghati Fatemeh , Taheri‐Behrooz Fathollah , Esmaili Ali 
Published: December 2023

AbstractThe mechanical properties of polymer matrix composites, such as fracture toughness, can be affected by the operating temperature. In this study, experimental and computational approaches were used to investigate the effect of temperature on the mode I fracture toughness of a glass/epoxy composite laminate filled with nanosilica particles. Double cantilever beam (DCB) tests were conducted at room temperature, 50°C and 65°C conditions on the glass/epoxy and 0.5 wt.% nanosilica/glass/epoxy composites. The addition of nanosilica to the glass/epoxy composites increased the initiation (Gini) and propagation (Gpro) fracture toughness by 7.3% and 39.5%, respectively, at room temperature. This was due to the enhanced bond strength of the fiber/matrix resulting from the addition of nanosilica. At a test temperature of 65°C, the initiation fracture toughness of the glass/epoxy and the glass/epoxy/ nanosilica increased by 22.4% and 22%, respectively, while the propagation fracture toughness increased by 64% and 28%, respectively. Numerical simulations using Abaqus software on two‐dimensional and three‐dimensional models confirmed the capability of cohesive zone models to simulate the load–displacement response of the specimens under different thermal conditions.
Dual‐method survey of recreational fishing for guitarfishes in Southern and Southeastern Brazil
Authors: Fuzetti Thomaz Stefani , Charvet Patricia , Wosnick Natascha 
Published: December 2023

AbstractWe comprehensively assessed marine recreational fishing of threatened guitarfishes (Pseudobatos percellens, Pseudobatos horkelii, and Zapteryx brevirostris) in Southern and Southeastern regions of Brazil. A dual‐method approach integrated social media reports and in‐person interviews to explore practices, challenges, and conservation implications of recreational fishing for these species. Seasonal capture of guitarfishes required the promotion of catch‐and‐release, especially during gestational periods, and the development of best angling practices manuals and accessible identification guides. With a focus on land‐based activities and engagement with fishers, our findings underscored the importance of collaboration among researchers, recreational fishers, and conservationists to map and monitor recreational capture and contribute to guitarfish research and conservation.
Scheduling‐location problem with drones
Authors: Kim Dongwook , Moon Ilkyeong 
Published: December 2023

AbstractDrone operation, a new driving force for logistics innovation, is struggling to overcome practical challenges. One of the concerns for drone utilization is limited flight ranges, and different concepts of facilities are continually developed to support drone delivery. These new facilities prompt the need to integrate decision‐making across different phases. In particular, the deployment of facilities that complement the physical limitations of drones and the scheduling of drones to perform delivery tasks are closely related. Therefore, we developed a scheduling‐location problem with drones, a new methodology for integrating operational and strategic planning decisions. The integrated decision‐making determines the location of the drone facilities by not only considering the critical distance of facilities but also by taking into account whether the delivery schedule is implemented. In our model, additional drone facilities are sometimes opened considering available drones due to the feasibility of the delivery schedule. An extended formulation and a restricted master heuristic are proposed to solve problems time‐efficiently. Computational results show that the restricted master heuristic outperforms the mathematical model in finding solutions for large‐scale instances. The developed model and heuristic algorithm provide drone delivery services even in areas that are not easily reachable by drones due to being located far from the warehouse and can be effectively applied to humanitarian logistics.
Effect of bevacizumab in combination with chemotherapy for ovarian cancer on wound healing in patients: A meta‐analysis
Authors: Xue Ying , Zhao Fang 
Published: December 2023

AbstractIn this meta‐analysis, we reviewed the findings and definitive findings of a new study that assessed the impact of bevacizumab on wound healing following combined chemotherapy for ovarian cancer (OC). The results of a controlled study that assessed the efficacy of bevacizumab in the treatment of ovarian cancer were retrieved from 4 databases, such as the Web of Science and EMBASE. The results of the adverse event associated with wound healing were determined by comparison of the controlled studies of bevacizumab plus chemotherapy in the treatment of ovarian cancer. A meta‐analysis was conducted with either a randomized or a fixed‐effect model in order to establish an odds ratio for time to event variables and for a binary outcome. In the research literature, 830 trials have been identified and seven have been chosen to be included in a definitive analysis of the trial. Among the 4134 cases who received chemotherapy after operation, 2098 received standard chemotherapy and 2036 received the addition of bevacizumab. A total of 7 trials have shown that the use of bevacizumab in the treatment of ovarian cancer patients has reduced wound healing (OR, 0.55; 95% CI: 0.37, 0.80, p = 0.002). Four trials demonstrated that there was no change in the incidence of haemorrhage in patients with ovarian cancer when administered with or without bevacizumab (OR, 0.48; 95% CI, 0.10, 2.34, p = 0.37). The combined use of bevacizumab and chemotherapy may have a negative effect on the healing of wound.
Nursing diagnoses as factors associated with delirium among intensive care unit patients with sepsis: A retrospective correlational study
Authors: Ji Hyunju , Oh Eui Geum , Choi Mona , Kim Ha Young , Kim Young Ah , Lee Kyung Hee 
Published: December 2023

AbstractAimsTo examine whether nursing diagnoses were associated with delirium in patients with sepsis.BackgroundNursing diagnosis is a nurse's clinical judgement about clients' current or potential health conditions. Delirium is regarded as an important nurse‐sensitive outcome. Nonetheless, nursing diagnoses associated with delirium have not yet been identified.DesignRetrospective correlational study.MethodsThis study was carried out from December 2021 to January 2023. We analysed electronic health records of patients with sepsis admitted to the intensive care units (ICUs) of a tertiary hospital in Seoul, South Korea. Delirium was defined based on the Intensive Care Delirium Screening Checklist score. Nursing diagnoses established within 24 h of admission to the ICU were included and were based on the North American Nursing Diagnosis Association diagnostic classification. The data were analysed using logistic regression. Demographics, comorbidities, procedures and physiological measures were adjusted. Regression model was evaluated via receiver operating characteristic curve, Nagelkerke R2, accuracy and F1 score.ResultsThe prevalence of delirium in patients with sepsis was 51.8%. Ineffective breathing patterns, decreased cardiac output and impaired skin integrity were significant nursing diagnoses related to delirium. Age ≥ 65 years, Acute Physiology and Chronic Health Evaluation II score, mechanical ventilation, continuous renal replacement therapy, physical restraint and comatose state were also associated with delirium in patients with sepsis. The area under the receiver operating characteristic curve was 0.806.ConclusionIneffective breathing patterns, decreased cardiac output and impaired skin integrity could manifest as prodromal symptoms of delirium among patients with sepsis.ImpactThe prodromal symptoms of delirium revealed through nursing diagnoses can be efficiently used to identify high‐risk groups for delirium. The use of nursing diagnosis system should be recommended in clinical practice caring for sepsis patients.Reporting MethodsSTROBE checklist.Patient or Public ContributionNo patient or public involvement.
Dispersal sweepstakes: Biotic interchange propelled air‐breathing fishes across the globe
Authors: Harrington Richard C. , Kolmann Matthew , Day Julia J. , Faircloth Brant C. , Friedman Matt , Near Thomas J. 
Published: December 2023

AbstractAimBiotic interchanges between Africa, India, and Eurasia are central to explaining the present‐day distribution and diversity of freshwater organisms across these landmasses. Synbranchiformes is a diverse and species‐rich clade of freshwater acanthomorph fishes found on all southern continents except Antarctica, and include eel‐ and perch‐like, air‐breathing and non‐air‐breathing fishes. Lacking a comprehensive and resolved phylogeny of the entire clade, contemporary interpretations of synbranchiform biogeography invoke scenarios as disparate as Gondwanan vicariance and pan‐global rafting to explain their modern‐day distribution. Here, we study their biogeographic history of continental dispersal events and test whether these are associated with increases in lineage diversification.LocationAsia, India, Africa freshwater habitats.TaxonSynbranchiformes (gouramis, snakeheads, swamp eels, and relatives).MethodsWe used nearly 1000 ultra‐conserved elements (UCEs) and Sanger‐sequenced genes to infer a phylogeny with representatives of all major synbranchiform lineages and nearly two‐thirds of its known species diversity. Incorporating fossil calibrations, we inferred a time‐calibrated phylogeny to which we apply Bayesian methods of ancestral area reconstruction and test for diversification rate shifts.ResultsAnalyses of UCE data provide a resolved phylogeny for major synbranchiform lineages. Divergence times support a most recent common ancestor of the entire clade approximately 79.2 million years ago. We infer significant increases in lineage diversification in both the spiny eels (Mastacembelidae) and the genus Betta (Osphronemidae).Main ConclusionsOur results reject the hypothesis of Gondwanan vicariance explaining synbranchiform biogeography. Instead, our analyses reconstruct a southeast Asian origin of the entire clade and independent dispersal events to other continents by snakeheads, anabantids, and spiny eels, with no signal of elevated lineage diversification occurring after these invasions. Higher lineage diversification rates in spiny eels pre‐date their arrival to Africa, while the high diversification rates observed in Betta were initiated prior to the flooding of insular Sundaland in southeast Asia.
Mobilisation during mechanical ventilation: A qualitative study exploring the practice of conscious patients, nurses and physiotherapists in intensive care unit
Authors: Lehmkuhl Lene , Dreyer Pia , Laerkner Eva , Olsen Hanne Tanghus , Jespersen Eva , Rothmann Mette Juel 
Published: December 2023

AbstractAimTo explore the practice of mobilisation of conscious and mechanically ventilated patients and the interaction between patients, nurses and physiotherapists.BackgroundLong‐term consequences of critical illness can be reduced by mobilisation starting in Intensive Care Units, but implementation in clinical practice is presently sparse.DesignA qualitative study with a phenomenological‐hermeneutic approach.MethodsParticipant observations in three Intensive Care Units involved twelve conscious mechanically ventilated patients, thirty‐one nurses and four physiotherapists. Additionally seven semi‐structured patient interviews, respectively at the ward and after discharge and two focus group interviews with healthcare professionals were conducted. The data analysis was inspired by Ricoeur's interpretation theory. The study adhered to the COREQ checklist.FindingsHealthcare professionals performed a balance of support and guidance to promote mobilisation practice. The complexity of ICU mobilisation required a flexible mobility plan. Furthermore, interaction with feedback and humour was found to be ‘a leverage’ for patient's motivation to partake in mobilisation.The practice of mobilisation found patients striving to cope and healthcare professionals promoting a ‘balanced standing by’ and negotiating the flexible mobility plan to support mobilisation.ConclusionThe study revealed a need to clarify interprofessional communication to align expectations towards mobilisation of conscious and mechanically ventilated patients.Relevance to Clinical PracticeThe study demonstrated the important role of healthcare professionals to perform a stepwise and ‘balanced standing by’ in adequately supporting and challenging the mobilisation of mechanically ventilated patients. Furthermore, a synergy can arise when nurses and physiotherapists use supplementary feedback and humour, and cooperate based on a flexible situation‐specific mobility plan in intensive care.
The important factors nurses consider when choosing shift patterns: A cross‐sectional study
Authors: Emmanuel Talia , Griffiths Peter , Lamas‐Fernandez Carlos , Ejebu Ourega‐Zoé , Dall'Ora Chiara 
Published: December 2023

AbstractAimTo gain a deeper understanding of what is important to nurses when thinking about shift patterns and the organisation of working time.DesignA cross‐sectional survey of nursing staff working across the UK and Ireland collected quantitative and qualitative responses.MethodsWe recruited from two National Health Service Trusts and through an open call via trade union membership, online/print nursing profession magazines and social media. Worked versus preferred shift length/pattern, satisfaction and choice over shift patterns and nurses' views on aspects related to work and life (when working short, long, rotating shifts) were analysed with comparisons of proportions of agreement and crosstabulation. Qualitative responses on important factors related to shift preferences were analysed with inductive thematic analysis.ResultsEight hundred and seventy‐three survey responses were collected. When nurses worked long shifts and rotating shifts, lower proportions reported being satisfied with their shifts and working their preferred shift length and pattern. Limited advantages were realised when comparing different shift types; however, respondents more frequently associated ‘low travel costs’ and ‘better ability to do paid overtime’ with long shifts and ‘healthy diet/exercise’ with short shifts; aspects related to rotating shifts often had the lowest proportions of agreement. In the qualitative analysis, three themes were developed: ‘When I want to work’, ‘Impacts to my life outside work’ and ‘Improving my work environment’. Reasons for nurses' shift preferences were frequently related to nurses' priorities outside of work, highlighting the importance of organising schedules that support a good work‐life balance.Relevance to Clinical PracticeGeneral scheduling practices like adhering to existing shift work guidelines, using consistent and predictable shift patterns and facilitating flexibility over working time were identified by nurses as enablers for their preferences and priorities. These practices warrant meaningful consideration when establishing safe and efficient nurse rosters.Patient or Public ContributionThis survey was developed and tested with a diverse group of stakeholders, including nursing staff, patients, union leads and ward managers.Reporting MethodThe Strengthening the Reporting of Observational Studies (STROBE) checklist for cross‐sectional studies was used to guide reporting.
Constructing the brief diagnostic criteria for temporomandibular disorders (bDC/TMD) for field testing
Authors: Durham Justin , Ohrbach Richard , Baad‐Hansen Lene , Davies Stephen , De Laat Antoon , Goncalves Daniela Godoi , Gordan Valeria V. , Goulet Jean‐Paul , Häggman‐Henrikson Birgitta , Horton Michael , Koutris Michail , Law Alan , List Thomas , Lobbezoo Frank , Michelotti Ambra , Nixdorf Donald R. , Oyarzo Juan Fernando , Peck Chris , Penlington Chris , Raphael Karen G. , Santiago Vivian , Sharma Sonia , Svensson Peter , Visscher Corine M. , Yoshiki Imamura , Alstergren Per ,   INfORM
Published: December 2023

AbstractBackgroundDespite advances in temporomandibular disorders' (TMDs) diagnosis, the diagnostic process continues to be problematic in non‐specialist settings.ObjectiveTo complete a Delphi process to shorten the Diagnostic Criteria for TMD (DC/TMD) to a brief DC/TMD (bDC/TMD) for expedient clinical diagnosis and initial management.MethodsAn international Delphi panel was created with 23 clinicians representing major specialities, general dentistry and related fields. The process comprised a full day workshop, seven virtual meetings, six rounds of electronic discussion and finally an open consultation at a virtual international symposium.ResultsWithin the physical axis (Axis 1), the self‐report Symptom Questionnaire of the DC/TMD did not require shortening from 14 items for the bDC/TMD. The compulsory use of the TMD pain screener was removed reducing the total number of Axis 1 items by 18%. The DC/TMD Axis 1 10‐section examination protocol (25 movements, up to 12 sets of bilateral palpations) was reduced to four sections in the bDC/TMD protocol involving three movements and three sets of palpations. Axis I then resulted in two groups of diagnoses: painful TMD (inclusive of secondary headache), and common joint‐related TMD with functional implications. The psychosocial axis (Axis 2) was shortened to an ultra‐brief 11 item assessment.ConclusionThe bDC/TMD represents a substantially reduced and likely expedited method to establish (grouping) diagnoses in TMDs. This may provide greater utility for settings requiring less granular diagnoses for the implementation of initial treatment, for example non‐specialist general dental practice.
Moderated paradoxical leadership: Resolving the innovation team leadership conundrum
Authors: Pearce Craig L. , van Knippenberg Daan 
Published: December 2023

AbstractMost discussions of innovation leadership focus on the role of the top leader. Such leaders are advised to be visionary, to control and coordinate the efforts of those below them, and to empower subordinates to engage in innovation activities. Most innovation efforts, however, also require teamwork, bringing together diverse individuals to combine divergent talents to develop novel solutions to complex problems. Leadership of such teams, research shows, benefits from shared leadership (e.g., Wassenaar & Pearce. 2018. The Nature of Leadership, 167–88). The rub is that these two sources of leadership are often seen as polar opposites and that the presence of the one negates the use of the other. We contend, however, that to realize the true potential of innovation teams requires the long‐run paradoxical integration and simultaneous deployment of both vertical and shared leadership, along with the short‐run tandem moderation of vertical versus shared leadership, depending on the issues confronting the team, as the innovation process unfolds. We synthesize the literature surrounding this issue and articulate a model of moderated paradoxical leadership to guide future research into this space.
Obesity intervention evidence synthesis: Where are the gaps and which should we address first?
Authors: Blaxall Michelle , Richardson Rachel , Schoonees Anel , Metzendorf Maria‐Inti , Durão Solange , Naude Celeste , Bero Lisa , Farquhar Cindy 
Published: December 2023

SummaryHealth professionals and policymakers rely on evidence synthesized from high quality research studies. Yet, there remain unanswered questions about how to prevent and treat obesity. In this research project, international practice guidelines and Cochrane systematic reviews were examined in order to identify gaps in the synthesized obesity intervention evidence base. One hundred and forty‐two partial or complete gaps were found. Systematic review questions to address these gaps were formulated and subjected to a prioritization consultation process with 36 international obesity expert stakeholders. Forty‐three review questions were priority‐assessed. The top 10 ranked review questions received support from at least 75.0% of stakeholders. The leading questions focused on preventive and community‐based approaches, including those delivered through primary‐care. Children within the context of their families were a highly‐prioritized target group, as were persons with diabetes or disabilities. Experts also prioritized reviews to determine which elements of programs are the most effective, and by which mode they are best delivered. Experts recommended that negative, psycho‐social, and longer‐term outcomes be captured in reviews. We request reviewers and funders to strongly consider addressing the top 10 leading prioritized review questions presented here.