bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Offset Strain Response on a Single Wellbore Equipped with Permanent and Disposable Fiber
Authors: Cox C. , Aljawfi F. , LeBlanc M. , Byrd G. D. 
Published: January 2025

Abstract
This study aims to improve the understanding of disposable fiber, a low-cost and increasingly popular option in cross-well monitoring. The research addresses industry concerns about the potential trade-offs associated with using disposable fiber, particularly focusing on fiber slippage and coupling effects on data interpretation. A central industry question is: "What are we giving up with disposable fiber?" Historically, attempts to answer this question have involved comparing disposable fiber data from one well with permanent fiber data from another, but varying well conditions have made this comparison inadequate.
A monitor wellbore offset to a multi-well pad stimulation was equipped with disposable fiber and permanent fiber to provide a true comparison of data from both deployment types. Multiple Fracture Driven Interactions (FDI's) from the stimulation were observed on both fibers throughout the project. The Low Frequency Distributed Acoustic Signal (LF-DAS) was analyzed to identify and compare key metrics such as the number of interactions, Volume to First Response (VFR), fracture azimuth, and Stage Domain Corridor (SDC) across the dataset. Additionally, a stage level, in-depth analysis of the LF-DAS data was performed to understand the impact of slippage on the strain signal for both deployment types.
The results demonstrate that several key strain metrics can be reliably obtained using disposable fiber. The results from the comparison are presented in detail along with a discussion of the limitations of disposable fiber and the interpretation of slippage effects. Our findings conclude that disposable fiber can be used confidently without significant loss of critical data, although its limitations should be well understood before implementing this technology.
This is the first publication presenting data from a wellbore equipped with both disposable and permanent fiber. The insights provided will offer the industry a clearer perspective on the trade-offs and benefits associated with disposable fiber, aiding in decision-making for hydraulic fracturing operations.
Mitigation Mechanism and Effect Evaluation of Hollow Microbeads Cement Sheath During Hydraulic Fracturing
Authors: Yan Y. , Han L. H. , Yang S. Y. 
Published: January 2025

Abstract
The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation.
E-GuARD: Expert-Guided Augmentation for Robust Interference Compound Detection
Authors: Palmacci Vincenzo , Nahal Yasmine , Welsch Matthias , Engkvist Ola , Kaski Samuel , Kirchmair Johannes 
Published: January 2025

Abstract

Assay interference caused by small organic compounds continues to pose formidable challenges to early drug discovery. Various computational methods have been developed to identify compounds likely to cause assay interference. However, due to the scarcity of data available for model development, the predictive accuracy and applicability of these approaches are limited. In this work, we present E-GuARD (Expert-Guided Augmentation for Robust Interference Compound Detection), a novel framework seeking to address data scarcity and imbalance by integrating self-distillation, active learning, and expert-guided molecular generation. E-GuARD iteratively enriches the training data with interference-relevant molecules, resulting in quantitative structure-interference relationship (QSIR) models with superior performance. We demonstrate the utility of E-GuARD with the examples of four high-quality data sets on thiol reactivity, redox reactivity, nanoluciferase inhibition, and firefly luciferase inhibition. Our models reached MCC values of up to 0.47 for these data sets, with two-fold or higher improvements in enrichment factors compared to models trained without E-GuARD data augmentation. These results highlight the potential of E-GuARD as a scalable solution to mitigating assay interference in early drug discovery.
Comparative genomic analysis of QTL for resistance to Aphanomyces euteiches between pea, lentil, faba bean and the model species Medicago truncatula
Authors: Leprévost Théo , Imbert Baptiste , Boutet Gilles , Lavaud Clément , Miteul Henri , Leduc Antoine , Aubert Grégoire , Kreplak Jonathan , Carrillo-Perdomo Estefania , Uhdre Renan , Sari Hatice , Bourland Britton , Caron Carolyn T. , Tayeh Nadim , Ma Yu , Coyne Clarice J. , Sugio Akiko , Pilet-Nayel Marie-Laure 
Published: January 2025

Abstract

Aphanomyces root rot, caused by Aphanomyces euteiches, is a damaging disease affecting various legume species. Quantitative trait loci (QTL) for partial resistance were previously identified mainly in pea, and also in lentil and Medicago truncatula. This study aimed to identify novel resistance loci from available populations in lentil and faba bean and examine genomic conservation of resistance QTL across legume host species.
QTL mapping in the Pop2 faba bean recombinant inbred line (RIL) population and genome-wide association study (GWAS) in the AGILE lentil diversity panel were performed for resistance to A. euteiches under controlled conditions, using genotyping data previously reported. A previous QTL mapping in the LR3 M. truncatula RIL population was updated using 1,536 new SNPs (single nucleotide polymorphisms). Synteny between resistance QTL to A. euteiches was analyzed based on gene orthology in the QTL regions projected onto genomes, using the OrthoLegKB graph database.
Four loci, including a major-effect QTL on chromosome 3, Ae-Vf3.1, were associated with resistance in faba bean. In lentil, six minor-effect GWAS-SNPs and two favorable haplotypes at Ae-Lc1.1 and Ae-Lc2.1 loci were identified. Updated analyses in M. truncatula narrowed to 8 Kb, including three candidate genes, the interval at the major-effect locus AER1. Synteny analysis identified 65 resistance QTL to A. euteiches overlapping 24 syntenic blocks defined between legume genomes. No synteny was highlighted between two major-effect QTL. These results pave the way for translational genomics approaches facilitating resistance gene discovery and for resistance QTL deployment strategies in legume rotations to preserve their durability.
Intrinsic, room temperature quantum resistance memristor for next generation zero-chain traceability SI standard
Authors: Valov Ilia , Milano Gianluca , Zheng Xin , Michieletti Fabio , Leonetti Giuseppe , Caballero Gabriel , Oztoprak Ilker , Boarino Luca , Bozat Ozgur , Callegaro Luca , De Leo Natascia , Godinho Isabel , Granados Daniel , Koymen Itir , Menghini Mariela , Miranda Enrique , Ribeiro Luis , Ricciardi Carlo , Sune Jordi , Cabral Vitor 
Published: January 2025

Abstract

The revision of the International System of Units opens new perspectives for the mise en pratique of SI units, fixing numerical values of fundamental constants of nature. Here, we show the realization of an intrinsic standard of resistance based on memristive devices working in air, at room temperature, directly accessible to the end user. Operating nanoionic cells in the quantum conductance regime, we report on a programming strategy based on the electrochemical polishing effects, allowing to control quantum conductance levels multiple of the fundamental unit of conductance and implement it as intrinsic standard values. The metrological consistency of results with respect to consensus values is verified, deviating -3.8 % and 0.6 % from of G0 and 2G0 values, respectively. Results pave the way for the implementation of National Metrological Institute services on-chip, towards the realization of self-calibrating systems with zero-chain traceability.
Discovery of a novel antibiotic, Transitmycin, from Streptomyces sp unveils highly efficient activities against tuberculosis and human immunodeficiency virus
Authors: Kumar Vanaja , Ramasamy Balagurunathan , Doble Mukesh , Manikkam Radhakrishnan , Hanna Luke Elizabeth , devi K R Uma , Arumugam Gandarvakottai Senthilkumar , Damodharan Kannan , Ganesan Suresh , Dusthakeer Azger , Lucia Precilla , Saadhali Shainaba A , John Shanthi , Eswaran Poongothai , UCA Jaleel , M Rakhila , Safeeda Ayisha , Sathish S , Nagamiah Selvakumar 
Published: January 2025

Abstract

HIV is identified as a factor that aggravates tuberculosis disease pathogenesis and its progression to latent TB. While, TB is declared as one of the major causes for AIDS-associated mortality. So there is a dire need for new drugs to combat such ailments that have a synergistic interaction.This has led us to study a novel antibiotic purified from a marine Streptomyces sp isolated from the coral reef ecosystem of South Indian coast. Streptomyces sp. R2 (MTCC 5597; DSM 26035)., isolated from the marine water was grown on agar plates and the crude yellowish orange pigment secreted was extracted using various solvents. The antibiotic, named as Transitmycin, was purified and tested against M. tuberculosis, drug resistant strains, and M. tuberculosis biofilm. The compound was also tested against HIV-1 viruses belonging to six subtypes. Several characterisation tools were used to elucidate the structure of this novel antibiotic. Transitmycin was derivitaised to elucidate the absolute configurations of the amino acids present in it. Tr, unlike actinomycin D, has L-valine in both the rings instead of D-valine (found in the latter). Also, one of the proline in Tr is in D–configuration while it is in L configuration in actinomycin D suggesting that ours is a novel compound and is not reported so far. It exhibits dual activities against the standard H37Rv, 49 drug sensitive clinical isolates, and MtB biofilm as well as standard and 20 clinical isolates of HIV. This is the first paper that reports the isolation of a new antibiotic from marine actinobacteria exhibiting unusual anti-TB and HIV activities which could be exploited further as a lead molecule in the quest for the design of drug with dual activities.
Breeding of the sea spider Phoxichildium femoratum (Rathke, 1799): functional anatomy perspective
Authors: Petrova Maria , Bogomolova Ekaterina 
Published: January 2025

Abstract

Sea spiders (Pycnogonida) are one of two arthropod taxa that exhibit external fertilization, making them interesting subjects for the reconstruction of plesiomorphic arthropod breeding features. However, data on pycnogonid breeding are limited, particularly their fertilisation was not observed at all. Most knowledge on of their breeding is mere assumptions based on occasional observations. In this work, we observed and photo- and video- recorded the breeding behaviour (courtship, oviposition, fertilization, and eggmass formation) of Phoxichilidium femoratum (Rathke, 1799). Additionally, we studied eggmasses for the presence of sperm and additional cement. The male initiates mating by climbing onto the female’s back and courts her until oviposition. During oviposition, the male gonopores are in proximity to the eggmass, and sperm is injected into the swollen vitelline envelope surrounding the laid eggs. Once oviposition is complete, the male leaves the female hooking the eggmass with one of his ovigers. No additional shaping of the eggmass by the male was recorded, nor was there any fastening of the eggs with additional cement. The eggs in the eggmass are secured solely by swollen vitelline envelopes. Thus, fertilization in a mucous eggmass is undoubtfully demonstrated for the species (and likely characteristic of most sea spiders). Our observation questions the cementing function of male femoral glands, widely accepted in review literature. Also, basing on comparison of P. femoratum with other sea spiders we suggest a hypothesis on eggmasses evolution.
How Relevant is Inflation Targeting in ECOWAS Common Currency Programme?
Authors: Kalu Ebere Ume , Nkwor Nelson , Ujunwa Austin , Al-Faryan Mamdouh Abdulaziz Saleh , Ujunwa Angela Ifeanyi , Okoyeuzu Chinwe 
Published: January 2025

Abstract

We examine the relevance of inflation targeting (IT) in the Economic Community of West African States’ (ECOWAS) common currency using the stability of money demand function to determine appropriate monetary policy framework. We employed annual data from 2003 to 2022 and autoregressive distributed lag (ARDL) bound test approach and find the presence of a long-run relationship between money demand function and its determinants. The CUSUM and CUSUM of square tests reveal the stability of money demand for the selected countries. Monetary targeting is more appropriate for ECOWAS since member countries have stable money demand. Based on the findings, we recommend the adoption of integrated inflation targeting framework, which involves setting flexible reserve money targets and interest rate corridors, sustaining a flexible exchange rate regime, and strengthening prudential supervision and regulation to promote financial system resilience against exchange rate shocks. This approach would promote policy transparency and accountability from inception.
JEL Classification: FO2, E41, E52, E5
Boundary Gauge Field-Induced Topological Hinge States in Photonic Metamaterials
Authors: Ma Shaojie , He Changsheng , Zhao Liang , Zhou Lei , Zhang Shuang 
Published: January 2025

Abstract

Higher-order topological insulators (HOTIs) can support boundary states at least two dimensions lower than the bulk, attracting intensive attention from both fundamental science and application sides. Lattice-based tight-binding models such as Benalcazar-Bernevig-Hughes model have driven significant advancements in realizing HOTIs across various physical systems. Here, beyond lattice model, we demonstrate that a cylinder with an arbitrary cross section, composed of a homogeneous electromagnetic medium featuring nontrivial second Chern numbers c2 = ±1 in a synthetic five-dimensional space, can exhibit topologically protected HOTI-type hinge states in three-dimensional laboratory space. Interestingly, this hinge state is essentially a chiral zero mode arising from the interaction between Weyl arc surface states, guaranteed by a nontrivial c2, and an effective magnetic field induced by the curvature of the cylinder surface. We experimentally realize such a cylinder using a photonic metamaterial and confirm the existence of hinge states via microwave near-field measurements. Our work introduces the concept of boundary gauge fields and establishes the link between synthetic-space c2 and real-space HOTI states, thereby generalizing HOTIs to corner-less systems.
Combined immune-peptide nanofiber with HSP70/AKT/mTOR axis blockade enhances near-infrared photoimmunotherapy, inhibiting tumor growth and recurrence
Authors: Du Yang , Zhang Xinyu , Jiang Zhenqi , Zhang Wenjia , Wu Juncheng , Guo Haozhuo , Li Changlei , Sun Mingwei , Xiaoying Tang , Huang Wei , Xue Huadan 
Published: January 2025

Abstract

Although immune checkpoint blockade (ICB) therapies have shown clinical benefit, ICB remains limited effect on most “immune-cold” solid tumors, i.e., tumors with low immune infiltration. Near-infrared photoimmunotherapy (NIR-PIT) converts “cold” tumors into “hot” tumors, thereby enhancing immune responses and improving ICB efficacy. Hence, developing a strategy that can integrate NIR-PIT and ICB treatment is desirable. In this study, we designed a unique carrier-free PSP@IR-CF3 nanofiber (NF), self-assembled from the PD-L1 targeting immune-peptide NTGYFYGDQ (PSP) and NIR-PIT agents (IR-CF3). The NFs enable precise tumor targeting and immune checkpoint inhibition by specifically binding to PD-L1 on the tumor cell surface, also providing an NIR-mediated photothermal effect. Applying PSP@IR-CF3 NFs with NIR induced mild NIR-PIT, which effectively activated the tumor immune microenvironment and treat tumors with lower immunotoxicity. Moreover, we identified that the HSP70/AKT/mTOR signaling pathway, which regulates tumor resistance and recurrence, was activated after PIT. By incorporating mTOR inhibitors like rapamycin, the combination treatment can reduce tumor resistance to NIR-PIT and decrease recurrence, thereby significantly improving therapeutic outcomes. This innovative combination therapy has the potential to revolutionize “cold” tumor treatment by offering more precise interventions that markedly enhance immunotherapeutic efficacy, reduce toxicity, and improve patient outcomes.
Optimizing Stock Price Prediction for South Asian Markets Using LSTM, GRU, CNN with Greedy Algorithm
Authors: Saeed Bushra , Yin Wei 
Published: January 2025

Abstract

Accurately predicting socio-economic trends, including stock market behavior, has become increasingly vital for investors, policymakers, and researchers in today's economic growth. This task is particularly challenging in South Asian nations due to the region's economic instability and the unpredictable nature of financial information. This paper aims to predict stock values in five prominent South Asian stock exchanges, namely Karachi (KSE), Nifty50 (NSE), Colombo (CSE), Dhaka (DSE), and Afghanistan, using machine learning methods and daily data from 2018 to 2023. To improve forecasting accuracy, this research used a greedy approach to optimize the window size of a Simple Moving Average (SMA) and normalized the data to train three deep learning models: Convolutional Neural Networks (CNN), Gated Recurrent Units (GRU), and Long Short-Term Memory (LSTM). The models were evaluated using performance metrics such as Mean Squared Error (MSE), Mean Absolute Error (MAE), and R2 score. Our results demonstrate that GRU outperforms LSTM and CNN in all markets, with reduced MSE and elevated R² values. However, CNN exhibits the most volatility in unstable markets, such as Afghanistan and Sri Lanka. LSTM provides more dynamic forecasting patterns but is prone to overestimating abrupt fluctuations in stock values. In summary, our research provides a comprehensive evaluation of machine learning models for stock price prediction and identifies GRU as the most reliable model.
Who objectifies girls on social media? the associations between ambivalent sexism and online objectification: A 13-month prospective study
Authors: Luo Yi-jun , Zhang Jing-qiu , Nie Qian , Chen Hong 
Published: January 2025

Abstract

Objectification has been linked to self-objectification and increased mental health risks, particularly among adolescent girls. While social media has grown increasingly popular in recent years, much remains unknown about who engages in online objectification behaviors on these platforms and the mechanisms underlying it. This study aimed to investigate the associations between ambivalent sexism, thin-ideal internalization and online objectification using a 13-month longitudinal design. A sample of 577 Chinese adolescents (aged 11–14 years; 270 girls, 307 boys) completed self-report measures at baseline (T1) and again at the 13-month follow-up (T2). Cross-lagged panel analyses revealed that T1 benevolent sexism was associated with increased T2 thin-ideal internalization and T2 online objectification, yet no significant association was found between T1 online objectification and T2 thin-ideal internalization or T2 benevolent sexism. Additionally, thin-ideal internalization mediated the relationship between benevolent sexism and online objectification. These findings suggest that benevolent sexism may be a significant risk factor for adolescent objectification on social media. Targeted interventions aimed at reducing benevolent sexism could serve as effective strategies to mitigate online objectification and its negative impacts on adolescent girls.
Ancient allopolyploidy and specific subgenomic evolution drive adaptive radiation in poplars and willows
Authors: Liu Jianquan , Wang Deyan , Li Mengmeng , Yang Wenlu , Chen Kai , Zhao Jiale , Shan Lanxing , Sun Pengchuan , Xu Li , Lu Zhiqiang , Li Yiling , Chen Yang , Xie Jiaxiao , Wang Yubo , Huang Heng , Luo Tiannan , Luo Jianglin , Jiang Yuanzhong , Hu Quanjun , Xi Zhenxiang , Olson Matthew , Ma Tao 
Published: January 2025

Abstract

Allopolyploidy involves the fusion of genomes from different lineages through hybridization and chromosome doubling. However, detecting early allopolyploidy events in evolutionary history and understanding the specific subgenomic evolution that contributes to the origin of adaptive innovations for species radiation can be challenging. Here, we sequenced the genomes representing all three subfamilies of Salicaceae, a woody model clade, and collected epigenetic and transcriptomic samples. We revealed one shared ancient allopolyploidy event involving Populus,Salix and two sister genera, but followed by contrasted karyotypic and subgenomic evolution. The specific evolution drove the origin of unique photoperiod adaptation, flowering phenology and small, hairy seeds in the highly speciose Populus and Salixwhen compared with their species-depauperate sister genera. These adaptive traits may have ultimately led to the ecological adaptations and species radiation in both poplars and willows. Our findings underscore the previously overlooked role of ancient allopolyploidization and specific subgenomic evolution for fostering adaptive innovation and species diversification at deep nodes of the plant tree of life.
One sentence summary: The specific subgenome evolution after ancient allopolyploidy drives the origin of unique adaptive traits that promote species radiation of the highly speciose Populus (poplars) and Salix(willows).
Summer Sea Ice Returns to the Western Arctic after a 25-year Hiatus
Authors: Moore G.W.K. , Zhang Jinlun , Schweiger Axel , Steele Michael , Ballinger Thomas 
Published: January 2025

Abstract

The Arctic Ocean has seen a profound sea ice loss during the summer, with changes most pronounced in the Western Arctic. This has resulted in the Chukchi Sea, located just north of Bering Strait, being ice-free by the end of summer since the late 1990s, except during 2024. Here, we investigate the processes responsible for the return of summer sea ice to the region during 2024. We show that an exceptional ice convergence event in February 2024, along with additional events in the winter and spring, resulted in ice thicknesses along the Siberian coast of the Chukchi Sea through the summer months that exceeded values seen in the region during the late 20th century. We argue that a thinner and more mobile ice pack contributed to this remarkable return of summer sea ice after a 25-year hiatus, opening the possibility of similar events in the future.