bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management pattern and medication-related harms and its predictors in colorectal cancer patients: an institutional-based retrospective study
Authors: Kefale Belayneh , Engidaw Melaku Tadege , Tesfa Desalegn , Molla Mulugeta , Kefale Yitayih , Tafere Chernet 
Published: October 2023

IntroductionData on colorectal cancer (CRC) patients’ thorough management practices and medication-related harms (MRH) are scarce. This study’s aim was to investigate the MRHs in patients receiving CRC chemotherapy at the comprehensive specialized hospital of the University of Gondar (UoGCSH).MethodsA registry-based retrospective cohort study was conducted on CRC patients at the UoGCSH during 2017–2021. From February to May 2022, medical records were reviewed using a pretested data collection tool to collect socio-demographic and disease-related characteristics, MRHs, and medication regimens. MRHs occurrence and adverse drug reactions (ADRs) severity were assessed using standard guidelines and protocols. Version 16/MP of STATA for Windows was used for the analysis. Independent predictors of MRHs were investigated using logistic regression analysis. A p-value ≤0.05 was used to determine an independent variable’s statistical significance.ResultsOne hundred forty three CRC patients were included, with a mean age of 49.9 ± 14.5 years. About 32.9% and 33.6% had stage II and III cancer, respectively. Significant patients had co-morbidities (15.4%) and complications (13.3%). Fluorouracil (5-FU)-based regimens were given to more than half (56%) of the patients. MRHs were found in 53.1% of the patients, with a mean of 2.45 ± 1.37 MRHs. The most common MRHs were the need for additional drug therapy, sub-therapeutic dose, DDIs, and ADRs. Being on stage IV (AOR = 27.7, 95% CI = 3.85–199.38, p = 0.001), having co-morbidity (AOR = 7.42, 95% CI = 1.80–30.59, p = 0.018) and having complication (AOR = 11.04, 95% CI = 1.72–70.95, p = 0.011) and treated with five or more drugs (AOR = 2.54, 95% CI = 1.07–6.07, p = 0.035) were independent predictors of MRHs.ConclusionA fluorouracil-based treatment regimen was most frequently used. MRHs were found in nearly half of CRC patients. Furthermore, MRHs were significantly associated with cancer stage, comorbidity and complication status, and the number of medications used. Because MRHs are common, improving clinical pharmacy services is critical for optimizing drug therapy in CRC patients.
Cross-sectional association between red blood cell distribution width and regional cerebral tissue oxygen saturation in preterm infants in the first 14 days after birth
Authors: Mu Yuju , Wang Hua , Tian Mengting , Hu Yong , Feng Yi , Lu Ruifeng , He Qi , Jiang Shouliang , Huang Jinglan , Duan Surong , Mu Dezhi 
Published: October 2023

BackgroundHypoxia can threaten the metabolic functions of different systems in immature neonates, particularly the central nervous system. The red blood cell distribution width (RDW) has recently been reported as a prognostic factor in neurologic diseases. Herein, we examined the correlation between RDW and regional cerebral tissue oxygen saturation (rcSO2).MethodsThis cross-sectional study included 110 preterm infants born at a gestational age (GA) of &lt;32 weeks, or with a birth weight (BW) of &lt;1,500 g at our institution between January and June 2,022. The rcSO2 was monitored using near-infrared spectroscopy, and RDW was extracted from the complete blood count during the first 14 days after birth. RDW and rcSO2 measurements were analyzed using a cross-sectional research method.ResultsWe divided the study population into two groups, with a mean rcSO2 value over the first 14 days. Fifty-three preterm had rcSO2 ≥ 55% and 57% &lt; 55%. The 14-days-mean in the study population showing an association of lower rcSO2 values with higher RDW values. Significantly higher RDW values were observed in the low rcSO2 group compared with those in the high rcSO2 group. Threshold effect analysis showed that rcSO2 decreased with RDW values ≥18% (β, −0.03; 95% CI, −0.04 and −0.02; p ≥ 0.0001). After adjusting for potential confounders, an RDW of ≥18% was determined as the predictive cutoff value for preterm infants with low rcSO2 (Model I: OR, 3.31; 95% CI, 1.36–8.06; p = 0.009; and Model II: OR, 3.31; 95% CI, 1.28–8.53; p = 0.013).ConclusionsAn RDW of ≥18% in the first 14 days is associated with rcSO2 of &lt;55% in preterm infants.
Effects of acute aerobic exercise on arterial stiffness in transgender men
Authors: Yamada Mizuki , Gam Hyunjun , Ikegami Nodoka , Nishikawa Yuriko , Ishikawa Akira , Funaki Akiko , Matsuda Tomoka , Kamemoto Kayoko , Hashimoto Yuto , Okamoto Takanobu , Yamazaki Hiroki , Tanaka Hirotoshi , Sakamaki-Sunaga Mikako 
Published: October 2023

Testosterone replacement therapy (TRT) in transgender men (TM) results in side effects such as elevated triglycerides and increased arterial stiffness. Exercise may be useful to ameliorate such effects, but no studies have examined the effects of acute aerobic exercise in TM. This study aimed to investigate the effects of acute aerobic exercise on arterial stiffness in TM. Thirty-six participants were included, comprising 12 TM (duration of TRT: 57.4 ± 30.3 months), 12 males and 12 females. All participants performed acute aerobic exercise on a treadmill at 50% heart rate reserve for 30 min. Arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) was measured before exercise (Pre), 30 min after exercise (Post30), and 60 min after exercise (Post60). Serum sex hormone levels, and serum lipid profile were determined only before exercise. Serum low-density lipoprotein cholesterol (LDL-C) levels before exercise were significantly higher in TM than in males or females (males: p &lt; 0.01; females: p &lt; 0.05). At all points, baPWV in TM was significantly higher than in females (p &lt; 0.05) and significantly lower than in males (p &lt; 0.05). However, when comparing changes in baPWV over time in each group, significant decreases in Post30 and Post60 were seen in males compared to Pre (both p &lt; 0.05), but no significant change after aerobic exercise was seen in TM or females. These results suggest that acute aerobic exercise yield different effects in TM than in males, but is unlikely to reduce arterial stiffness in TM receiving TRT.
Spoken discourse in episodic autobiographical and verbal short-term memory in Chinese people with dementia: the roles of global coherence and informativeness
Authors: Kong Anthony Pak-Hin , Cheung Ryan Tsz Him , Wong Gloria H. Y. , Choy Jacky C. P. , Dai Ruizhi , Spector Aimee 
Published: October 2023

IntroductionMemory and discourse production are closely related in healthy populations. A few studies in people with amnestic mild cognitive impairment and people with dementia (PWD) suggested similar links, although empirical evidence is insufficient to inform emerging intervention design and natural language processing research. Fine-grained discourse assessment is needed to understand their complex relationship in PWD.MethodsSpoken samples from 104 PWD were elicited using personal narrative and sequential picture description and assessed using Main Concept Analysis and other content-based analytic methods. Discourse and memory performance data were analyzed in bivariate correlation and linear multiple regression models to determine the relationship between discourse production and episodic autobiographical memory and verbal short-term memory (vSTM).ResultsGlobal coherence was a significant predictor of episodic autobiographical memory, explaining over half of the variance. Both episodic autobiographical memory and vSTM were positively correlated with global coherence and informativeness, and negatively with empty speech indices.DiscussionCoherence in personal narrative may be supported by episodic autobiographical memory and vice versa, suggesting potential mechanism of interventions targeting personhood through conversation. Indices of global coherence, informativeness, and empty speech can be used as markers of memory functions in PWD.
Poverty and inequality in real-world schizophrenia: a national study
Authors: Fond Guillaume B. , Yon Dong Keon , Tran Bach , Mallet Jasmina , Urbach Mathieu , Leignier Sylvain , Rey Romain , Misdrahi David , Llorca Pierre-Michel , Schürhoff Franck , Berna Fabrice , Boyer Laurent 
Published: October 2023

BackgroundSchizophrenia has high socioeconomic impact among severe psychiatric disorders.AimsTo explore clinician-reported and patient-reported inequities between patients under the poverty threshold vs. the others.Method916 patients consecutively recruited in 10 national centers received a comprehensive standardized evaluation of illness severity, addictions and patient-reported outcomes.Results739 (80.7%) of the patients were classified in the poverty group. This group had poorer objective illness outcomes (lower positive, negative, cognitive, excitement/aggressive and self-neglect symptoms and lifetime history of planned suicide) in multivariate analyses. While they had similar access to treatments and psychotherapy, they had lower access to socially useful activities, couple’s life, housing and parenthood. They had also more disturbed metabolic parameters. On the contrary, the poverty group reported better self-esteem. No significant difference for depression, risky health behavior including addictions and sedentary behavior was found.InterpretationThe equity in access to care is attributed to the French social system. However, mental and physical health remain poorer in these patients, and they still experience poor access to social roles independently of illness severity and despite healthcare interventions. These patients may have paradoxically better self-esteem due to decreased contact with society and therefore lower stigma exposure (especially at work). Schizophrenia presents itself as a distinct impoverished population concerning health-related outcomes and social integration, warranting focus in public health initiatives and improved treatment, including tailored interventions, collaborative care models, accessible mental health services, housing support, vocational training and employment support, community integration, education and awareness, research and data collection, culturally competent approaches, and long-term support.
Sunglass tint does not impact the indoor catching performance of cricket fielders
Authors: Christie C. J. , Nellemann S. , Davies T. , Fourie J. L. , Davy Jonathan Patrick 
Published: October 2023

IntroductionSunglasses are worn by outdoor athletes such as cricketers for many reasons, including comfort and glare reduction, which may help to improve vision. Anecdotally they are purported to have performance-enhancing benefits, but there is a lack of evidence for this. Further, it appears that fielders are the only position in cricket who wear sunglasses. Therefore, this study aimed to compare the catching performance of fielders when wearing three different colour sunglasses tints during an indoor, laboratory-based experiment.MethodsTwenty-one male cricketers currently playing for a university or amateur provincial teams in Makhanda, South Africa, who were non-habitual sunglass wearers, were recruited for this study. An optometrist administered pre-screening tests. Players had four testing sessions during which they wore a different colour tint at each session indoors (clear, blue, G30 (rose), and red). Players were required to catch 18 balls projected from a bowling machine. The number of balls caught, as well as the quality of the catch, was recorded. At the final session, they were asked which tint they thought was best.ResultsPre-screening tests showed that the red lens was best for contrast sensitivity and stereopsis. During data collection, sunglass tint did not affect catching performance. The players perceived the red lens as the worst and the G30 as the best.DiscussionIt can be concluded that catching performance indoors is not affected by tint colour.
HUBUNGAN ANTARA TINGKAT DEPRESI PADA LANSIA DENGAN KEJADIAN INSOMNIA DI PANTI SASANA TRESNA WERDHA “KARYA BHAKTI” YAYASAN KARYA BHAKTI RIA PEMBANGUNAN CIBUBUR TAHUN 2016
Authors: Sumarno Agus , Salam Ana Sukriah 
Published: October 2023

Lansia sering kali mengalami masalah psikologis atau depresi yang disebabkan masalahpensiun, gangguan fisik, kematian orang yang dicintai, dan masalah ekonomi yang mengakibatkanlansia sering mengalami gangguan tidur. Depresi adalah perubahan suasana hati yang buruk, sehinggaketika seseorang mengalami depresi, maka orang tersebut akan merasa sedih berkepanjangan, putusharapan, dan kesepian. Sedangkan insomnia adalah kesulitan seseorang untuk memulai tidur ataumempertahankan tidur dalam kurun waktu tertentu. Penelitian ini bertujuan mengidentifikasiHubungan antara Tingkat Depresi pada Lansia dengan Kejadian Insomnia di Panti Sasana TresnaWerdha “Karya Bhakti” Yayasan Karya Bhakti Ria Pembangunan Cibubur. Metode Penelitianmenggunakan deskriptif korelatif dengan pendekatan cross sectional. Populasi berjumlah 64 orangdengan menggunakan rumus Slovin diperoleh ukuran sampel sebesar 55 responden yang dipilih secararandom. Pengumpulan data menggunakan kuesioner, yang selanjutnya dianalisis denganmenggunakan uji Chi-Square. Hasil penelitian menunjukkan tingkat depresi tertinggi 47,3% yangterindikasi depresi ringan dan 63,3% yang mengalami kejadian insomnia. Dari hasil analisis diperolehnilai Chi-Square (χ2
) = 3.129 < χ2
0,05(2)= 5,99. Kesimpulan tidak ada hubungan yang signifikan antaratingkat depresi pada lansia dengan kejadian insomnia karena p value > 5 %. Saran penulisdiperlukannya lansia terhindar dari depresi dan kejadian insomnia.
HUBUNGAN BEBAN KERJA DENGAN TINGKAT STRES KERJA PADA CAREGIVER DI PANTI SOSIAL TRESNAWERDHA BUDI MULIA 03 CIRACAS JAKARTA TIMUR
Authors: Rakhmaningrum Mega , Idris Muhamad 
Published: October 2023

Pendahuluan sebagai seorang caregiver, yang memberikan perawatan terutama untuk orang tua, menuntut pengorbanan yang besar, baik secara fisik dan emosional. Beban kerja yang berlebihan dapat menimbulkan stress kerja. Stres negatif dapat berdampak pada kesehatan fisik caregiver atau menyebabkan caregiver secara fisik atau verbal agresif terhadap klien atau lansia, salah satu alasan untuk penelantaran dan kekerasan pada lansia adalah stress pada caregiver. Tujuan penelitian untuk mengetahui hubungan beban kerja dan tingkat stress kerja pada pekerja sosial sebagai caregiver di Panti Sosial Tresna Werdha Budi Mulia 03 Ciracas Jakarta Timur. Metode Penelitian deskriptif korelasi. Jumlah populasi adalah sebanyak 80 caregiver. Sampel diambil dengan teknik total sampling. Hasil penletian analisis yang digunakan univariat dan bivariat menggunakan chi – square dengan = 5%. Pada nilai Chi – Square statistik yang digunakan Continuity Correction dengan nilai = 0,003 ini lebih kecil dari = 5% atau 0,05 maka hipotesis ditolak. Simpulan terdapat hubungan beban kerja dengan tingkat stres kerja pada caregiver di Panti Werdha Tresna Werdha Budi Mulia 03 Ciracas Jakarta Timur. Saran maka Dinas Sosial DKI Jakarta penelitian ini diharapkan dapat menjadi referensi untuk memberikan masukan dalam penentuan kebijakan pembagian tugas pada caregiver disetiap hari.
HUBUNGAN PENGGUNAAN LAMPU PADA SAAT TIDUR DENGAN KUALITAS TIDUR REMAJA DI SMK KESDAM JAYA JAKARTA
Authors: Oktaviana Vina , Sukmalara Dini 
Published: October 2023

Tidur merupakan salah satu kebutuhan dasar manusia yang termasuk dalam kebutuhan fisiologis. Kualitas tidur adalah kondisi baik atau buruk dari kebiasaan tidur seseorang. Kondisi kurang tidur yang dialami oleh remaja di pengaruhi oleh beberapa faktor, salah satunya adalah cahaya. Cahaya lampu yang digunakan pada saat tidur yang terlalu terang dapat menembus kelopak mata dan merangsang otak untuk tetap beraktivitas dan menyebabkan seseorang sulit tidur karena tubuh dan otak tidak dapat beristirahat secara penuh. Tujuan Penelitian untuk mengetahui hubungan Penggunaan Lampu pada saat Tidur dengan Kualitas Tidur Remaja di SMK Kesdam Jaya Jakarta. Metode penelitian deskriptif korelasi, Populasi sebanyak 84 responden, sampel diambil dengan teknik purposif sampling menggunakan rumus slovin menjadi 69 responden. Analisis yang digunakan univariat dan bivariat menggunakan uji Chi-Square α=5%. Hasil penelitian uji Chi-Square, didapatkan p value 0.015 (p<0.05), maka H0 ditolak dengan nilai Cmaks sebesar 0,432. Simpulan terdapat hubungan penggunaan lampu pada saat tidur dengan kualitas tidur remaja. Saran diharapkan kepada remaja dapat mengetahui baiknya penggunaan cahaya lampu dalam posisi lampu yang mati pada saat tidur untuk memberikan kualitas tidur yang baik.

Sleep is one of the basic human needs which is included in physiological needs. Sleep quality is a good or bad condition of a person's sleep habits. Sleep deprivation experienced by adolescents is influenced by several factors, one of which is light. The light used during sleep that is too bright can penetrate the eyelids and stimulate the brain to stay active and cause a person to have difficulty sleeping because the body and brain cannot rest fully. The research purposes was to determine the relationship between the use of lights during sleep and the quality of adolescent sleep at SMK Kesdam Jaya Jakarta. Research Method use correlation descriptive a population of 84 respondents the sample was taken by purposive sampling technique using the Slovin formula to be 69 respondents. The analysis used univariate and bivariate using the Chi-Square test α = 5%. The results of the Chi-Square test, obtained p value 0.015 (p <0.05), then H0 is rejected with a Cmax value of 0.432. conclusion there is a relationship between the use of lights during sleep and the quality of adolescent sleep. Suggestions are expected that adolescents can find out whether the use of lights in the position of the lights is off during sleep to provide good quality sleep.
HUBUNGAN TINGKAT STRESS DENGAN KEJADIAN INSOMNIA PADA LANJUT USIA DI BALAI REHABILITASI SOSIAL LANJUT USIA BUDHI DHARMA KOTA BEKASI
Authors: Pipit Pipit , Sumarno Agus 
Published: October 2023

Penuaan merupakan proses alamiah yang tidak dapat dihindari, berjalan terus menerus dan berkesinambungan. Pada lanjut usia, kondisi dan fungsi tubuh akan semakin menurun, sehingga semakin banyak keluhan yang terjadi. Kondisi ini juga menimbulkan berbagai dampak buruk bagi fisik dan psikis lansia, antara lain kecemasan, stress, gangguan mood, gangguan tidur, dan substance abuse yang nantinya akan berujung pada kualitas hidup lanjut usia. Tujuan penelitian Untuk mencari hubungan antara tingkat stres dengan kejadian insomnia pada lanjut usia di Balai Rehabilitasi Sosial Lanjut Usia Budhi Dharma Kota Bekasi. Metode penelitian Kuantitatif dengan desain penelitian deskriptif korelasional serta menggunakan pendekatan cross sectional. Teknik pengambilan sampel yaitu total sampling. Sampel pada penelitian ini berjumlah 45 responden. Pengambilan data menggunakan kuesioner dan wawancara. teknik analisis data menggunakan chi-square. Hasil penelitian menggunakan Chi-Square untuk melihat adanya hubungan antara tingkat stres dengan kejadian insomnia, hasil nilai p atau Asym. Sig. (2-sided) = 0,005 lebih kecil dari α = 5% (0,05), maka hipotesis H0 ditolak dan Ha diterima. Simpulan Terdapat hubungan antara tingkat stres dengan kejadian insomnia pada lansia di Balai Rehabilitasi Sosial Lanjut Usia Budhi Dharma Kota Bekasi dengan tingkat hubungan yang kuat. Saran peneliti menganjurkan agar Balai Rehabilitasi Sosial Lanjut Usia Budhi Dharma Kota Bekasi.mengadakan terapi aktivitas kelompok yang lebih bervariasi, memberikan fasilitas terbaik, dan memberikan terapi farmakologis atau psikologis untuk lansia.
La familia del español broza y brezo y sus congéneres romances
Authors: Santano Moreno Julián 
Published: October 2023

L’article porte sur deux familles lexicales représentées par l’espagnol broza
“broussailles” et brezo “bruyère”. Les deux familles ont une large correspondance dans d’autres langues romanes. À travers une analyse de type phonétique l’on a cherché à établir les bases indoeuropéennes pour chaque famille : la racine *bhreu- “gonfler ; bourgeonner” pour broza et *uroiko-, *ueroi-k-, *u(e)r(ei)-k- pour celle de brezo. Notre analyse distingue nettement les deux familles du point de vue étymologique et présente une plus complexe articulation que ce que avait été considéré.
A proposito di un articolo recente: i precetti di mise en page di Sigismondo Fanti
Authors: Agati Maria Luisa , Gavrila Caius 
Published: October 2023

As part of a new approach to codicology, which uses direct observation of the manuscript to analyse the gestures and criteria behind the work of the medieval artisan, we see a growing
interest in the few sources concerning those instructions on the mise-en-page of the handwritten book which sanction relations of proportion. A recent contribution (in Scrineum 2013) challenges the interpretation of the «recipes » we are already familiar with today, and especially that of Fanti, the mathematician from Ferrara. Written in the vernacular, it is a fresh
start, which allows us to set his Trattato di Scrittura Theorica et pratica in the wider context of sixteenth-century theorisations, and attempt a definitive interpretation of his Consideratio XVI dedicated to the construction precepts behind the layout of a book.
La dernière édition eusébienne de l’Histoire Ecclésiastique : une nouvelle proposition
Authors: Andrist Patrick 
Published: October 2023

Comme Eduard Schwartz, l’éditeur du texte critique usuel, l’a montré, l’HE nous est parvenue en deux familles textuelles principales. Pour expliquer l’état de ces deux familles, Schwartz, sur la base d’une analyse serrée des douze passages qui contiennent les différences majeures entre elles, était arrivé à la conclusion que la dernière édition eusébienne correspondrait à la famille 1, plus courte, alors que la famille 2, plus longue, serait le résultat du travail d’un réviseur. Malheureusement, comme une étude récente l’a mis en évidence, la méthode d’analyse de Schwartz ne résiste pas à une évaluation critique. Plutôt que de vouloir trancher entre la famille 1 et la famille 2, nous proposons de remonter vers la dernière édition eusébienne en analysant les différences, type par type, indépendamment les uns des autres. Sur cette base, nous attribuons à Eusèbe le texte long de la famille 2 quand celui de la famille 1 s’explique au mieux par une diminution ; et le texte court de la famille 1 quand celui de la famille 2 s’explique au mieux par une augmentation. De l’édition ε ainsi reconstruite on peut postuler l’existence d’une rédaction κ, à la base des diminutions à caractère politique de la famille 1, et d’une rédaction π, à la base des documents et des
récits supplémentaires de la famille 2
Arithmetic, music, and cosmology in a thirteenth-century Boethian source: Parma, Biblioteca Palatina, Parmense 718
Authors: Pieragostini Renata 
Published: October 2023

Le manuscrit conservé aujourd’hui à la Bibliothèque palatine de Parme sous la cote 718 – sans doute compilé dans le Nord de la France à la fin du XIIIe siècle – contient une copie du De musica de Boèce, jusqu’à présent inconnue des musicologues. On y trouve également le De arithmetica de Boèce et divers traités, parmi lesquels un bref traité sur le monochorde, une série de diagrammes sur la classification des connaissances et un poème sur la position des planètes.
Il est intéressant de constater que la combinaison des textes contenus dans le manuscrit de Parme offre une similitude frappante avec une source nettement plus ancienne : le manuscrit Paris BNF lat. 7203, manuscrit d’origine française de la fin du XIe ou du début du XIIe siècle. Le volume de Parme a certainement été copié à partir d’éléments dérivant de ce manuscrit plus ancien. Il apporte un nouvel éclairage sur la transmission des apprentissages dans les domaines de la théorie musicale, de la cosmologie et de l’arithmétique au XIIe et XIIIe siècle.