bluuebunny/crossref_metadata_2025_split huggingface dataset:
An exploratory modelling and analysis protocol for identifying robust policy mixes for clean energy transitions: An exploratory analysis for Mexico
Authors: Castrejon-Campos Omar , Aye Lu , Hui Felix Kin Peng , Vaz-Serra Paulo 
Published: November 2023

Abstract
This protocol presents a systematic approach for conducting exploratory modelling and analysis (EMA) to identify robust policy mixes for clean energy transitions. It explores the effects of diverse policy alternatives and multiple uncertainties within energy transitions through computational experiments. The protocol comprises diverse steps, including Decision Framing, Policy Alternatives Generation, Experiment Setting, Performing Experiments, Policy Alternatives Analysis, Performance Metrics Analysis, and Medium and Long-term Policy Analysis. It also integrates analytical sub-processes such as Policy Objectives Analysis, Feature Scoring, Robustness Analysis, Vulnerability Analysis, and Trade-off Analysis. The effectiveness of this protocol is demonstrated through its successful implementation in Mexico. Targeted at researchers, policymakers, and energy analysts, it offers a comprehensive method for in-depth exploration of the potential effects of diverse policy alternatives and multiple uncertainties within energy systems. While acknowledging that the duration of completion depends on available computational resources, it provides a detailed approach to conducting EMA for energy transitions.
Effects of Prediabetes and Type 2 Diabetes on Cognitive Functions
Authors: Sen Gulin Alkan , tanrıkulu seher , beşer birsu , akçakalem şükriye , çakır sibel , Dinççağ nevin 
Published: November 2023

Abstract
Introduction: We aimed to investigate the effect of glycemic impairment in prediabetes on cognitive impairment, and the impact of glycemic control on cognitive function in patients with diabetes.
Materials and Methods: This age- and sex-matched case-control study included a total of 80 individuals: 20 patients with prediabetes, 20 patients with well-controlled type 2 diabetes mellitus (T2DM) (HbA1C<%7.5), 20 patients with poorly controlled T2DM (HbA1C >% 7.5), and 20 healthy controls.
Results: The poorly controlled T2DM patients performed significantly worse than controls and patients with prediabetes in the verbal memory process test (p = 0.041). In Trail Making Test B, the well-controlled and poorly-controlled groups with diabetes performed significantly worse (p = 0.015) than patients with prediabetes and controls, and in the Wisconsin Card Sorting Test (WCST), all three patient groups performed significantly worse (p = 0.007) than controls.
Conclusion: T2DM causes early brain aging and declines cognitive functions since the prediabetic stage. Poor glycemic control in T2DM patients contributes to cognitive impairments, especially in learning.
Lymphoid Organs’ Metabolism and its Role in Predicting the Outcomes of Patients with Malignant Melanoma Treated with Immunotherapy – an Exploratory Study
Authors: De Rimini Maria Luisa , Bianchi Andrea , Annovazzi Alessio , D'Arienzo Davide , Valente Tullio , Sciuto Rosa , Traglia Silvia Di , Nappi Anna Giulia , Ferrari Cristina , Rubini Giuseppe , Panareo Stefano , Urso Luca , Bartolomei Mirco , Aricò Demetrio , Bombaci Michelangelo , Caponnetto Domenica , Gusella Sara , Spimpolo Alessandro , Carriere Cinzia , Balma Michele , Buschiazzo Ambra , Gallicchio Rosj , Storto Giovanni , Filippi Luca , Evangelista Laura 
Published: November 2023

Abstract
Background.
This study aimed to evaluate the changes in 2-[18F]-FDG PET/CT parameters of lymphoid organs and their association with clinical outcomes in melanoma patients undergoing immunotherapy.
Materials and methods.
Ninety-two consecutive patients with malignant melanoma were enrolled in the study. Patients underwent serial 2-[18F]-FDG PET/CT scans at baseline (PET0), 6 months (PET1), 18 months (PET2), and 36 months after starting immunotherapy. Visual and semiquantitative analyses were performed by two experienced nuclear medicine specialists. Mean standardized uptake values (SUVmean) of the liver and spleen were measured, and the Spleen Liver Ratio (SLR) was calculated. Clinical assessments and disease outcomes were recorded based on physical examinations, routine blood work, serum chemistry studies, and conventional imaging. Progression-free survival (PFS) and overall survival (OS) were also determined.
Results.
Most patients received anti-PD1 therapy, and radiotherapy was combined with systemic treatment in some cases. After 6, and 18 months, clinical disease control was achieved in 74% and 74%, respectively. Patients without clinical disease control exhibited higher bone marrow FDG uptake and an increase in the sites of metabolic lesions. Median SLR values were slightly higher in patients without disease control after 6 and 18 months, but lower after 36 months. At PET0, the median SLR at PET0 was higher in alive patients than who died, while it was similar in the following scans. Patients with signs of inflammation on PET1 had a higher baseline SLR, which decreased in the subsequent PET2 scan.
Conclusions.
Changes in bone marrow FDG uptake may serve as potential indicators of treatment response and disease outcomes. SLR would be considered an interesting predictive and prognostic indicator. This study provides insights into the dynamic changes of metabolic parameters during immunotherapy and their clinical implications in malignant melanoma patients.
Prediction of the Mechanism of Suicide amongst Minnesota Residents utilizing Data from the Minnesota Violent Death Reporting System (MNVDRS)
Authors: Waller Daniel C , Wolfson Julian , Gingerich Stefan , Ramirez Marizen 
Published: November 2023

Abstract
Background
Suicide is the 8th leading cause of death in Minnesota (USA), with a firearm being selected as the means of suicide in approximately half of all such events. This study sought to predict the occurrence of suicide specifically by firearm, as opposed to any other means of suicide, in order to help inform possible life-saving interventions.
Methods
This study involved the use of data from the Minnesota Violent Death Reporting System (MNVDRS), a database that tracks data across a multitude of sources for individuals who died a violent death in the state. Data categories vary from basic demographic information to more personal characteristics. Prediction models were developed utilizing different sets of variables tracking different categories of personal information in order to understand the improvement in prediction accuracy relative to the effort required to collect information for the prediction model. Models were built with and without data imputation, with logistic regression models constructed for non-imputed data and random forest models constructed for imputed data. Models were evaluated for prediction accuracy utilizing Area Under the Curve (AUC) analysis and for proper calibration.
Results
Results showed that the addition of social determinant and personal history data to predictive models led to an increased level of prediction accuracy in comparison to models constructed with basic demographic information only. No significant differences were observed between imputed and non-imputed models. The model fitted with the 20 variables ranked with highest importance by random forest models resulted in the highest AUC in the study (AUC: 0.732; 95% CI: 0.694 to 0.770).
Conclusions
The study demonstrated that the use of a firearm in a death by suicide, as opposed to any other means of suicide, can be reasonably well predicted when an individual’s social determinants and personal history are considered. These predictive models could help to inform many prevention strategies, such as safe storage practices, background checks for firearm purchases, or red flag laws.
Transcriptomic and genomic characteristics of intrahepatic metastases of primary liver cancer
Authors: Zou Weilong , Fang Zhanjie , Feng Yu , Gong Shangjin , Li Ziqiang , Li Meng , Sun Yong , Ruan Xiuyan , Fang Xiangdong , Qu Hongzhu , Li Haiyang 
Published: November 2023

Abstract

Background
Patients with primary multifocal hepatocellular carcinoma (HCC) have a poor prognosis and often experience a high rate of treatment failure. Multifocal HCC is mainly caused by intrahepatic metastasis (IM), and though portal vein tumor thrombosis (PVTT) is considered a hallmark of IM, the molecular mechanism by which primary HCC cells invade the portal veins remains unclear. Therefore, it is necessary to recognize the early signs of metastasis of HCC to arrange better treatment for patients.
Results
To determine the differential molecular features between primary HCC with and without phenotype of metastasis, we used the CIBERSORTx software to deconvolute cell types from bulk RNA-Seq based on a single-cell transcriptomic dataset. According to the relative abundance of tumorigenic and metastatic hepatoma cells, VEGFA+ macrophages, effector memory T cells, and natural killer cells, HCC samples were divided into five groups: Pro-T, Mix, Pro-Meta, NKC, and MemT, and the transcriptomic and genomic features of the first three groups were analyzed. We found that the Pro-T group appeared to retain native hepatic metabolic activity, whereas the Pro-Meta group underwent dedifferentiation. Genes highly expressed in the group Pro-Meta often signify a worse outcome.
Conclusions
The HCC cohort can be well-typed and prognosis predicted according to tumor microenvironment components. Primary hepatocellular carcinoma may have obtained corresponding molecular features before metastasis occurred.
Peripheral neuropathy mimicking Guillain-Barre syndrome in a patient with severe refeeding syndrome: a case report
Authors: Liang Tianya , Zhang Meng , Chen Liang , Luo Huan , Yang Xiaolei , Fu Donglin , Yang Jin 
Published: November 2023

Abstract
Background: Refeeding syndrome (RS) is a potentially serious condition and frequently ignored without uniform definition. Severe refeeding syndrome may present with symptoms of thiamine deficiency (TD) with poor outcome. Prevention in high-risk populations and timely treatment of clearly diagnosed patients may improve outcomes.Case presentation: A 58-year-old patient with fulminant myocarditis who received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) ran into severe RS during the recovery period after ECMO was successfully removed. Considering thiamine deficiency as a result of severe refeeding syndrome, patients were given empiric thiamine 100mg intramuscularly once a day. The peripheral neuropathy mimicing Guillain-Barre syndrome (GBS), cardiac insufficiency, and hyperlactemia were improved after 5 days following thiamine supplementation.Conclusion: Refeeding syndrome often occurs, and it is very harmful. The clinical manifestations of refeeding syndromes are diverse. Proper management of refeeding syndrome is very important to improve patient outcomes.
The risk factors Of Hemorrhoidal disease： A Mendelian randomization study
Authors: Yu Miaozhi , Yuan Shang , Han Lingling , Yu Xi 
Published: November 2023

Abstract
Hemorrhoids are the most common perianal disease, but current observational studies have yielded inconsistent results in investigating the etiology. Our further exploration of the etiology will help prevent the disease. We conducted a two-sample bidirectional Mendelian randomization (MR) analysis using publicly available genome-wide association studies (GWAS) statistics from multiple consortia. The inverse-variance weighted (IVW) method was used for the primary analysis. We applied four complementary methods, including weighted median, weighted mode, MR-Egger regression, and Cochrane's Q value, to detect and correct the effects of horizontal pleiotropy. Genetically determined constipation (OR = 0.97, 95% CI: 0.91–1.03, P = 0.28) and diarrhea (OR = 1.00, 95% CI: 0.99–1.01, P = 0.90) did not have a causal effect on HEM but stool frequency (OR = 1.28, 95% CI: 1.05–1.55, P = 0.01), waist-to-hip ratio adjusted for BMI (OR = 1.11, 95% CI: 1.06–1.64, P = 1.59×10− 5), and order Burkholderiales (OR = 1.09, 95% CI = 1.04–1.14, p = 1.63×10− 4) had a causal effect on. Furthermore, we found a significant causal effect of constipation on HEM in the reverse MR analysis (OR = 1.21, 95% CI: 1.13–1.28, P = 3.72×10− 9). The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. Horizontal pleiotropy was unlikely to distort the causal estimates, as indicated by the sensitivity analysis. Our MR analysis reveals a causal association between stool frequency and waist-to-hip ratio with HEM, despite variations in results reported by observational studies. Unexpectedly, we found a relationship between the order Burkholderiales in the gut flora and HEM, although the mechanism is unclear.
Effect of receiving counseling for SARS-CoV-2 infection prevention on the adoption of hygiene, isolation and quarantine measures: Sulcovid-19 survey
Authors: Rocha Juliana Quadros Santos , Caputo Eduardo Lucia , Petry Letícia , Vieira Yohana Pereira , Duro Suele Manjourany Silva , Saes Mirelle Oliveira 
Published: November 2023

Abstract

Background: We aimed to investigate the associations between receiving counseling for protective measures and the actual adoption of hygiene, isolation, and quarantine measures in individuals infected with SARS-CoV-2.
Methods: We analyzed baseline data from the Sulcovid-19 study, a longitudinal research project conducted in southern Brazil.Participants were asked if they received counseling from healthcare professionals on protective measures against COVID-19. Participants were also queried about their behavior regarding hygiene, self-isolation, and quarantine measures during their SARS-CoV-2 infection. Participants' behavior status was categorized based on their responses into four categories: 1) remained without adopting, 2) began to adopt, 3) stopped adopting, and 4) remained adopting. We conducted adjusted analyses using Poisson regression with robust variance adjustment. All variables with a p-value ≤ 0.20 were included in the model. Associations with 95%CI that did not overlap between categories were considered statistically significant.
Results: Receiving counseling increased the likelihood of "staying in a well-ventilated and individualized room" by 25.0% (PR: 1.25 95%CI 1.17; 1.33), "avoiding sharing space" by 14.0% (PR: 1.14 95%CI 1.06; 1.23), "performing hand hygiene" by 9% (PR: 1.09 95%CI 1.06; 1.12), and "using a facial mask" by 34% (PR: 1.34 95%CI 1.25; 1.43). Receiving counseling increased the likelihood of adopting all behaviors during infection by 4% (PR: 1.04 95%CI 1.02; 1.06). Receiving counseling enhanced the probability of adhering to hygiene, isolation, and quarantine measures both during and after SARS-CoV-2 infection.
Conclusions: This underscores the effectiveness of healthcare counseling in influencing behavior in the battle against the COVID-19 pandemic.
How does FinTech impact entrepreneurial behavior among farmers? Evidence from the China Household Finance Survey
Authors: XU FENG , SUN YI , ZHOU YINI , YU DONGYAO 
Published: November 2023

Abstract

FinTech is disrupting the traditional financial models with the power of technology. Will it solve the problems faced by farmers in starting their own businesses and stimulate the vitality of rural entrepreneurship? In this paper, we focus on the impact of FinTech on the entrepreneurial behavior of farmers in China. First, we analyze the current state of FinTech in China and propose corresponding theoretical hypotheses regarding its impact on farmer entrepreneurship. Second, using data from Baidu search index and the China Household Finance Survey (CHFS), we employ a Probit model to verify our theoretical hypotheses. Our findings suggest that (1) FinTech development encourages farmer entrepreneurial behavior; (2) It achieves this by alleviating credit constraints, information constraints, and risk aversion effects; (3) The positive effect of FinTech on farmer entrepreneurship is more significant for individuals with lower education or income levels as well as those residing in central or western regions. Overall, our study provides timely insights into boosting farmer entrepreneurship in emerging countries like China by leveraging the potential of FinTech.
Chlorogenic acid content and metabolism-related gene regulation of potato tuber flesh induced by sucrose and phytohormones
Authors: YANG Huiqin , Luo Wei , Gao Dongli 
Published: November 2023

Abstract

Chlorogenic acid (5-O-caffeoylquinic acid, CGA) is the most important phenolic compound in potatoes, which is one of the material foundations for potato insect resistance and disease resistanc. However, excessive chlorogenic acid can affect the taste of potatoes. The application of exogenous phytohormones is an effective technical method to regulate CGA metabolism through gene expression of transcriptional regulatory pathways. Herein, we determined the content of CGA under the application of sucrose and multiple phytohormones, and explored the expression changes of related genes. As a proof-of-concept, the effects of exogenous sucrose and multiple phytohormones on CGA metabolism in potato tuber flesh were investigated. The CGA content was significantly decreased in sucrose-treated potato tuber tissues, as well as in those treated with abscisic acid (ABA) or salicylic acid (SA) or methyl jasmonate (MeJA). Among these treatments, the effect of SA was the most obvious. Meanwhile, the expression changes of six major enzyme genes involved in potato CGA metabolism, including phenylalanine ammonia-lyase (PAL), 4-coumarate coenzyme A ligase (4CL), hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase (HQT), hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase (HCT), ρ-coumarate 3’-hydroxilase (C3H), and caffeoyl shikimate esterase (CSE) were analyzed. Under sucrose treatment, HQT was downregulated, whereas three genes (PAL, 4CL, and CSE) were notablely upregulated, and expressions of HCT and C3H did not show significant changes. ABA induced the expression of HCT, but inhibted the expression of PAL, 4CL, HQT, C3H, and CSE. The expression of all six enzyme genes PAL, 4CL, HQT, HCT, C3H, and CSE were downregulated under SA treatment. MeJA induced the expression of HQT, but inhibited the expression of PAL, 4CL, HCT, C3H, and CSE. Collectively, sucrose and phytohormones can regulate CGA accumulation in potato tuber flesh by regulating the expression levels of genes involved in the CGA pathway. These results provided a theoretical basis for further elucidating the transcriptional regulation mechanism of CGA metabolism.
Degeneration of Potato Varieties Due to Virus Incidence in North Gujarat
Authors: PATEL JIGNESHKUMAR Kanaiyalal , Patel Ramjibhai Narsinhbhai , ZAPADIYA DALSUKHBHAI Manjibhai , Vaghela Shravansinh Jamatsinh 
Published: November 2023

Abstract
The physiological causes and viral disease infections are the two main reasons for potato degeneration. The seed potato diseased with viral diseases degenerated in the following successive generation therefore the investigation was carried out to evaluate the most popular potato varieties of Gujarat i.e. K. Badshah and K. Khyati against viruses and their subsequent degenerative effects on yield with comparison to fresh breeder seed. The three different treatments viz., T1: Fresh breeder seed every year, T2: Previous seed produce using seed plot technique, T3: Previous seed produce without seed plot technique were evaluated. The studies were conducted for four consecutive years during rabi 2017–2021. The result revealed significantly higher per cent plant emergence at 40 DAP was recorded in T1 (Fresh breeder seed every year) and T2 (Previous seed produce using seed plot techniques) in all years as compared to T3 (Previous seed produce without seed plot techniques). The per cent incidence of viral diseases at 75 DAP was recorded highest (mild mosaic:16.67%, severe mosaic: 17.67 and PLRV 21.83 in last year) in T3 i.e. Previous seed produce without seed plot techniques. Comparatively lower per cent incidence of viral diseases (mild mosaic:10.67%, severe mosaic: 7.33 and PLRV 13.33 in last year) was recorded in T2 i.e. Previous seed produce using seed plot techniques and the least incidence of viral diseases (Mild mosaic:1.83%, Severe mosaic: 1.67 and PLRV 1.67 in last year) was recorded in T1 i.e. Fresh breeder seed every year.
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome
Authors: Stapleton Saluda , Welch Grace , DiBerardo Lindsay , Freeman Linnea Ruth 
Published: November 2023

Abstract
Background:Recent decades have seen an exponential rise in global obesity prevalence, with rates nearly doubling in a span of forty years. A comprehensive knowledge base regarding the systemic effects of obesity is required to create new preventative and therapeutic agents effective at combating the current obesity epidemic. Previous studies of diet-induced obesity utilizing mouse models have demonstrated a difference in bodyweight gain by sex. In such studies, female mice gained significantly less weight than male mice when given the same high fat (HF) diet, indicating a resistance to diet-induced obesity. Research has also shown sex differences in gut microbiome composition between males and females, indicated to be in part a result of sex hormones. Understanding metabolic differences between sexes could assist in the development of new measures for obesity prevention and treatment. This study aimed to characterize sex differences in weight gain, plasma lipid profiles, fecal microbiota composition, and fecal short chain fatty acid levels. We hypothesized a role for the gut microbiome in these sex differences that would be normalized following microbiome depletion.
Methods:A mouse model was used to study these effects. Mice were divided into treatment groups by sex, diet, and presence/absence of an antibiotic cocktail to deplete genera in the gut microbiome. We hypothesized that sex differences would be present both in bodyweight gain and systemic measures of obesity, including hormone and circulating free fatty acid levels.
Results:We determined statistically significant differences for sex and/or treatment for the outcome measures. We confirm previous findings in which male mice gained significantly more weight than female mice fed the same high fat diet. However, sex differences persisted following antibiotic administration for microbiome depletion.
Conclusions:We conclude that sex differences in the gut microbiome may contribute to sex differences in obesity, but they do not explain all of the differences.
Effective Prime Factorization via Quantum Annealing by Modular Locally-structured Embedding
Authors: Ding Jingwen , Spallitta Giuseppe , Sebastiani Roberto 
Published: November 2023

Abstract
This paper investigates novel techniques to solve prime factorizationby quantum annealing (QA).First, we present a very-compact modular encoding of amultiplier circuit into the architecture of current D-Wave QA devices.The key contribution is a compact encoding of a controlled full-adderinto an 8-qubit module in the Pegasus topology, which we synthesizedby means of Optimization Modulo Theories. This allows us to encode upto a 21×12-bit multiplier (and a 22×8-bit one) into the Pegasus5760-qubit topology of current annealers. To the best of ourknowledge, these are the largest factorization problems ever encodedinto a quantum annealer.Second, we investigated the problem of actually solving encodedPF problems by running an extensive experimental evaluation on aD-Wave Advantage 4.1 quantum annealer. In the experiments weintroduced different approaches to initialize the multiplier qubitsand adopted several performance enhancement techniques. Overall,8,219,999=32,749×251 was the highest prime product we were able tofactorize within the limits of our QPU resources. To the best of ourknowledge, this is the largest number which was ever factorized bymeans of a quantum device.