bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial correspondence in relative space regulates serial dependence
Authors: Lim Jaeseob , Lee Sang-Hun 
Published: October 2023

AbstractOur perception is often attracted to what we have seen before, a phenomenon called ‘serial dependence.’ Serial dependence can help maintain a stable perception of the world, given the statistical regularity in the environment. If serial dependence serves this presumed utility, it should be pronounced when consecutive elements share the same identity when multiple elements spatially shift across successive views. However, such preferential serial dependence between identity-matching elements in dynamic situations has never been empirically tested. Here, we hypothesized that serial dependence between consecutive elements is modulated more effectively by the spatial correspondence in relative space than by that in absolute space because spatial correspondence in relative coordinates can warrant identity matching invariantly to changes in absolute coordinates. To test this hypothesis, we developed a task where two targets change positions in unison between successive views. We found that serial dependence was substantially modulated by the correspondence in relative coordinates, but not by that in absolute coordinates. Moreover, such selective modulation by the correspondence in relative space was also observed even for the serial dependence defined by previous non-target elements. Our findings are consistent with the view that serial dependence subserves object-based perceptual stabilization over time in dynamic situations.
Effects of iguratimod on inflammatory factors and apoptosis of submandibular gland epithelial cells in NOD mice
Authors: Wang Shuying , Yu Jiake , Yang Jie , Ge Yan , Tian Jing 
Published: October 2023

AbstractNon-obese diabetic (NOD) mice were taken as primary Sjögren’s syndrome (pSS) model mice to examine the therapeutic impact of iguratimod (IGU) on inflammatory factors levels and apoptosis of submandibular epithelial cells, and provide experimental basis for the treatment of pSS by iguratimod. Twenty-four NOD murine models were divided into the model, high-dose (IGU 30 mg/kg) and low-dose (IGU 10 mg/kg) groups, eight mice per group. The normal control group comprised eight C57B/L mice. From 8 weeks of age, the NOD mice were administered IGU by intragastric gavage administration every day for 8 weeks; their water consumption, saliva secretion, submandibular gland, and spleen indices were measured. The levels of serum inflammatory factor (IL-1β, TNF-α, IL-6, and IL-17) were evaluated, and Bax, caspase-3, and Bcl-2 levels were detected. The histological alterations in the submandibular glands were discovered. IGU can reduce the water intake of NOD mice (p < 0.01), increase the saliva secretion and the submandibular gland index (p < 0.01); reduce the spleen index and the serum inflammatory factors (p < 0.01); improve the pathological tissue damage and cell apoptosis of the submandibular gland (p < 0.05). IGU can reduce the expression levels of inflammatory mediators in the serum and the extent of lymphocyte infiltration and apoptosis in submandibular gland epithelial cells. It can also regulate apoptosis-related protein expression, thereby improving the secretory function of exocrine glands.
Identification of ONECUT3 as a stemness-related transcription factor regulating NK cell-mediated immune evasion in pancreatic cancer
Authors: Shi Haojun , Tsang Yiusing , Yang Yisi , Chin Hok Leong 
Published: October 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) has a dismal response to the current T cell-based immunotherapies, which is attributed to intratumoral heterogeneity caused by PDAC stem cells and lack of major histocompatibility complex class I required for neoantigen presentation. Although this scenario makes natural killer (NK) cells attractive candidates for immunotherapeutic agents targeting MHC-I-deficient cancer stem cells in heterogeneous PDACs, little is known about PDAC stem cell immunology. In our study, PDAC-specific datasets from public databases were collected for in-depth bioinformatic analysis. We found that the abundance of PDAC stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-cancer Stemness Signature levels. A series of NK cell-targeted inhibitory immune checkpoints were highly expressed in ONECUT3high PDACs. The patient group with high levels of ONECUT3 expression had a high risk of poor overall survival, even if accompanied by high infiltration of NK cells. Furthermore, the prostanoid metabolic process was enriched in ONECUT3high PDACs with high levels of NK cell-targeted inhibitory immune checkpoints. ONECUT3 enriched in high-stemness PDACs possessed the potential to transcriptionally regulate the prostanoid metabolism-related genes. Our study reveals ONECUT3 as a candidate stemness-related transcription factor regulating NK cell-targeted inhibitory immune checkpoints in PDAC. ONECUT3-mediated prostanoid metabolism may regulate cancer stemness and immune evasion in PDAC. Synergistic inhibition of prostanoid metabolism may improve the efficacy of NK cell-based immunotherapies targeting intratumoral heterogeneity caused by PDAC stem cells.
Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
Authors: Ide Soichiro , Hirai Toshitake , Muto Takafumi , Yamakawa Tomio , Ikeda Kazutaka 
Published: October 2023

AbstractOpioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid receptor (KOP) is a member of the opioid receptor system that has been gaining attention as a promising molecular target for the treatment of numerous human disorders, including pain, depression, anxiety, and drug addiction. Here, we biologically and pharmacologically evaluated a novel azepane-derived ligand, NP-5497-KA, as a selective KOP agonist. NP-5497-KA had 1000-fold higher selectivity for the KOP over the μ-opioid receptor (MOP), which was higher than nalfurafine (KOP/MOP: 65-fold), and acted as a selective KOP full agonist in the 3′,5′-cyclic adenosine monophosphate assay. The oral administration of NP-5497-KA (1–10 mg/kg) dose-dependently suppressed morphine-induced conditioned place preference in C57BL/6 J mice, and its effects were comparable to an intraperitoneal injection of nalfurafine (1–10 μg/kg). Nalfurafine (10 μg/kg) significantly inhibited rotarod performance, whereas NP-5497-KA (10 mg/kg) exerted no effect on rotarod performance. These results indicate that NP-5497-KA may be a novel option for the treatment of opioid use disorder with fewer side effects.
Objective greenness, connectedness to nature and sunlight levels towards perceived restorativeness in urban nature
Authors: Spano Giuseppina , Ricciardi Elisabetta , Theodorou Annalisa , Giannico Vincenzo , Caffò Alessandro Oronzo , Bosco Andrea , Sanesi Giovanni , Panno Angelo 
Published: October 2023

AbstractThe beneficial effect of exposure to nature and immersion in natural environments on perceived well-being is well established. Nevertheless, we acknowledge an emerging need to disentangle the role of specific environmental features from individual factors that encourage a positive person-environment interaction. This study aimed at evaluating the associations between four buffer distances of greenness and dimensions of perceived restorativeness, with connectedness towards nature (CTN) as a confounder variable, in a sample of 312 visitors to a large urban park. Variables investigating ecosystem services (ES, e.g., thermal comfort) were included as covariates. Results revealed differentiated effects of greenness level, sunlight intensity, and connectedness to nature in the pathways towards dimensions of restorativeness. Greenness level at 300 m was associated with Fascination, Scope, and Being Away, while at 500 m was associated with Coherence, Scope, and Being Away. ES was found to be associated with Coherence, while CTN with the other three dimensions of restorativeness. The moderating effect of sunlight level in the relationship between NDVI buffer distances and the total score of perceived restorativeness was also confirmed. The present work is intended to offer insights on the interplay between environmental features and individual differences for implications in several contexts, including the opportunity to develop tailor-made planning for urban forestry.
Improved performance of UV-blue dual-band Bi2O3/TiO2 photodetectors and application of visible light communication with UV light encryption
Authors: Zheng Qin , Xu Jianping , Shi Shaobo , Chen Jing , Xu Jianghua , Kong Lina , Zhang Xiaosong , Li Lan 
Published: October 2023

In this article, Bi2O3/TiO2 heterojunction PDs were obtained by modulating TEA concentration in the precursor liquid. The UV-blue dual-band photoresponse characteristics exhibited by the devices are utilized to realize in visible light communication.
Barriers to Follow-Up in Early Hearing Detection and Intervention Programs
Authors: Warner-Czyz Andrea D. , Crow Sarah , Gohmert Andrea , Williams Stephanie , Romero Michael 
Published: October 2023

Purpose:
The Joint Committee on Infant Hearing recommends hearing screening before 1 month of age, audiologic diagnosis before 3 months of age, and enrollment in early intervention before 6 months of age (1-3-6 benchmarks of Early Hearing Detection and Intervention [EHDI] programs). Nearly 98% of newborns have their hearing screened, but many, who do not pass or do not complete their newborn hearing screening, fail to complete the EHDI process. Historically, lower socioeconomic level, more complex infant health status, and farther geographical location reduce rates of EHDI follow-up, but levels vary widely across states. This study examined barriers to the EHDI process by comparing census-based variables at the state and regional levels to national and Texas EHDI outcomes, respectively.

Method:
We used correlational analysis to assess relationships between U.S. Census data (state- and region-specific population and geographic characteristics, sociodemographic and geographic factors, and health and health insurance) and EHDI data (newborn screening, audiologic diagnosis, and early intervention) at the national level and in Texas.

Results:
Nationally, higher labor force participation, lower unemployment rates, and presence of health insurance significantly correlated with higher rates of completing EHDI benchmarks. Larger population size and density and higher socioeconomic factors coincided with higher rates of completing the EHDI process and lower rates of loss to follow-up (LTF) or loss to documentation in Texas.

Conclusions:
Population, socioeconomic, and demographic factors significantly correlate with following through with the EHDI process, with weak correlations at the national level and strong correlations at the state level. These findings underscore the need to increase our attention to underserved, economically challenged, and/or geographically distanced families who have children with a higher risk of becoming LTF in the EHDI process.
The evolution of sulphur-bearing molecules in high-mass star-forming cores
Authors: Fontani F. , Roueff E. , Colzi L. , Caselli P. 
Published: October 2023

Context. To understand the chemistry of sulphur (S) in the interstellar medium, models need to be tested by observations of S-bearing molecules in different physical conditions.
Aims. We aim to derive the column densities and abundances of S-bearing molecules in high-mass dense cores in different evolutionary stages and with different physical properties.
Methods. We analysed observations obtained with the Institut de RadioAstronomie Millimétrique (IRAM) 30 m telescope towards 15 well-known cores classified in the three main evolutionary stages of the high-mass star formation process: high-mass starless cores, high-mass protostellar objects, and ultracompact HII regions.
Results. We detected rotational lines of SO, SO+, NS, C34S, 13CS, SO2, CCS, H2S, HCS+, OCS, H2CS, and CCCS. We also analysed the lines of the NO molecule for the first time to complement the analysis. From a local thermodynamic equilibrium approach, we derived the column densities of each species and excitation temperatures for those that are detected in multiple lines with different excitation. Based on a statistical analysis of the line widths and the excitation temperatures, we find that NS, C34S, 13CS, CCS, and HCS+ trace cold, quiescent, and likely extended material; OCS, and SO2 trace warmer, more turbulent, and likely denser and more compact material; SO and perhaps SO+ trace both quiescent and turbulent material, depending on the target. The nature of the emission of H2S, H2CS, and CCCS is less clear. The molecular abundances of SO, SO2, and H2S show the strongest positive correlations with the kinetic temperature, which is thought to be an indicator for evolution. Moreover, the sum of all molecular abundances shows an enhancement of gaseous S from the less evolved to the more evolved stages. These trends could be due to the increasing amount of S that is sputtered from dust grains owing to the increasing protostellar activity with evolution. The average abundances in each evolutionary group increase, especially in the oxygen-bearing molecules, perhaps due to the increasing abundance of atomic oxygen with evolution owing to photodissociation of water in the gas phase.
Conclusions. Our observational work represents a test-bed for theoretical studies aimed at modelling the chemistry of sulphur during the evolution of high-mass star-forming cores.
The Relationship Between Serum Fibroblast Growth Factor 23 and Klotho
Protein and Low Bone Mineral Density in Middle-Aged and Elderly Patients with
End-Stage Renal Disease
Authors: Huang Ting , He Yicao , Li Ye , Zhang Haisong , Wang Qian , Gao Yan 
Published: October 2023

AbstractTo assess the correlation between serum fibroblast growth factor 23
(FGF-23)/Klotho levels and end-stage renal disease (ESRD) in middle-aged
and elderly patients combined with low bone mineral density (BMD). The BMD of
the lumbar vertebrae and femoral neck of 87 patients with ESRD was measured
using a dual-energy X-ray bone densitometer during hospitalisation and the
patients were divided into a normal bone mass group and a low bone mass group.
Haemoglobin, albumin, urea nitrogen, uric acid, creatinine, low-density
lipoprotein cholesterol, alkaline phosphatase, blood calcium, blood phosphorus
and full parathyroid hormone were detected using an automatic biochemical
analyser. The levels of serum FGF-23, Klotho and activated vitamin D in the
patients with ESRD were measured via an enzyme-linked immunosorbent assay. Older
age and decreased serum creatinine levels and serum Klotho levels were
associated with low bone mass. There were significantly more men in normal bone
mass group (n=49, 74.24%) than in low bone mass group
(n=8, 38.10%). The correlation analysis showed that BMD was
negatively correlated with age but positively correlated with serum Klotho. The
binary logistic regression analysis indicated that old age and the decrease in
serum Klotho level were independent risk factors of a low BMD (all
p<0.05). In conclusion, serum Klotho is closely related to BMD changes
in middle-aged and elderly patients with ESRD. A high Klotho level is a
protective factor and is expected to be a marker in reducing bone mineral
metabolism disorders and improving the prognosis of patients with ESRD.
Diskriminierung von Kindern und Jugendlichen mit Geschlechtsinkongruenz oder
Geschlechtsdysphorie in der medizinischen und psychotherapeutischen Versorgung
Authors: Hädicke Maximiliane , Föcker Manuel , Romer Georg , Wiesemann Claudia 
Published: October 2023

Zusammenfassung
Einleitung Schutz vor Diskriminierung ist ein Menschenrecht. Dennoch belegen empirische Studien,
dass bestimmte soziale Gruppen, etwa trans Personen, Diskriminierung im Gesundheitswesen erfahren. Wie
kann es dazu kommen?
Forschungsziele Wir haben am Beispiel der medizinischen Versorgung von Kindern und Jugendlichen
mit Geschlechtsinkongruenz/Geschlechtsdysphorie (GI/GD) untersucht, vor welchen spezifischen
Herausforderungen Ärzt*innen und Psychotherapeut*innen stehen, was sie unter Diskriminierung verstehen
und wie sie mit den Minderjährigen umgehen.
Methoden Das Projekt folgt methodologisch einem empirisch-ethischen Ansatz. Es wurden 17
leitfadengestützte, qualitative Expert*inneninterviews mit Ärzt*innen und Psychotherapeut*innen in
Deutschland geführt, die professionellen Kontakt zu Kindern und Jugendlichen mit GI/GD haben oder hatten.
Die Interviews wurden mithilfe der thematischen Inhaltsanalyse ausgewertet. Es wurde eine Begriffsmatrix
zu „Diskriminierung“ genutzt, um spezifische Diskriminierungsrisiken zu identifizieren.
Interessenverbände waren an der Studie beratend beteiligt.
Ergebnisse Die Interviewten sehen sich mit zahlreichen Herausforderungen konfrontiert, wenn sie
Minderjährige mit GI/GD psychotherapeutisch oder medizinisch begleiten. Dazu zählen etwa das ethische
Spannungsfeld zwischen Fürsorgeverantwortung für Kinder/Jugendliche und Respekt für ihre
Behandlungswünsche, das Ringen mit professionellen Organisations-, Behandlungs- und Sprachroutinen sowie
technischen Hindernissen. Während einige der Befragten mit hohem Engagement nach Wegen suchen, um diese
Herausforderungen zu bewältigen, greifen andere auf destruktive Bewältigungsstrategien wie Victim
Blaming zurück.
Schlussfolgerung Die Ergebnisse lassen neue Rückschlüsse auf spezifische Gefahren der
Diskriminierung für Kinder und Jugendliche mit GI/GD im Gesundheitswesen zu. Professionell Tätige sind
dafür zu sensibilisieren, dass insbesondere professionelle Routinen eigene Diskriminierungsrisiken für
ihre minderjährigen Patient*innen mit GI/GD erzeugen. Fortbildungs- und institutionelle
Unterstützungsangebote sollten das berücksichtigen. Es ist allerdings auch eine gesamtgesellschaftliche
Aufgabe, die sozialen und institutionellen Handlungsbedingungen von Ärzt*innen und Psychotherapeut*innen
so zu gestalten, dass sie einer diskriminierungssensiblen Gesundheitsversorgung dienlich sind.
Ketone-Derived Pro-aromatic Reagents for Radical Group Transfer Reactions and Deconstructive Functionalizations
Authors: Librando Ivy L. , Liao Hsuan-Hung , Miñoza Shinje 
Published: October 2023

AbstractThe recent prominence of ketones as handles for sp3-rich radicals has expanded the paradigm of synthetic utility of ketones, putting the ubiquitous functional group once again into the spotlight in recent years. One emerging strategy arose through ketone-derived pro-aromatic reagents in the form of dihydrobenzothiazoline (BTZ), dihydroquinazolinone (DHQZ), dihydropyrazole (DHP), and dihydro-1,2,4-triazole (DHT) as key intermediates for aromaticity-promoted C–C bond homolytic fission. The formed sp3-radicals could then participate in various radical functionalizations, including alkylations, arylations, olefination, alkynylation, silylations, amination, thiolation, and deuteration, among others, either in photocatalytic, thermal, or oxidative conditions. In this review, we highlight the implications and recent advances in using these pro-aromatic reagents in radical group transfer reactions and deconstructive functionalization.1	Introduction2	Aromatization-Driven C–C Bond Scission of Ketones3	Photochemical Reactions of Ketone-Derived Pro-aromatic Reagents4	Non-photochemical Reactions of Ketone-Derived Pro-aromatic Reagents5	Conclusion and Future Outlook
Organoselenium Compounds in Catalysis
Authors: Rodríguez Juan B. , Gallo-Rodriguez Carola 
Published: October 2023

AbstractIn this article we have focused on the use of selenium in catalysis along with the proposed reaction mechanisms. With increasing interest in selenium chemistry, we have highlighted the most significant features of this subject, mainly in the last years. Selenium-containing catalysts have a key role in many transformations; for example, oxidation reactions that are performed under very mild and controlled conditions. In addition, utilizing the weak selenium–oxygen bonding interaction has proved to be very useful as a catalytic approach for specific transformations. The catalytic cycles of each appropriate transformation are fully reviewed.1	Introduction2	Use of Selenium in Catalysis: Perspectives2.1	Selenium as Directing Group: Preparation of Organoselenium Compounds via C–H Borylation2.2	Multicomponent Reactions Employing Selenium as a Catalyst2.3	Selenium-π-Acid Catalysts2.4	Electrochemical Selenium-Catalyzed Reactions2.5	Stereoselective Synthesis Employing Organoselenium Catalysts2.6	Transition-Metal Catalysts Containing Selenium-Based Ligands2.6.1	Selenium-Ligated Palladium(II) Complexes as Catalysts for the Heck Reaction2.6.2	Pincer Selenium Catalyst for the Allylation of Aldehydes and Closely Related Functional Groups2.6.3	Selenium Employed in Buchwald-Type C–N Coupling Reactions2.6.4	Organoselenium Catalysts in Suzuki–Miyaura Coupling Reactions2.7	Organoselenium Catalysis in Michael-Type Reactions2.8	Catalytic Cycle for Glutathione Peroxidase2.9	Epoxidation2.10	Dihydroxylation2.11	Oxidation2.12	Bromolactonization2.13	Preparation of Alkenes from Vicinal Diols2.14	Preparation of α-Selanyl Enals from Propargylic Alcohols2.15	Miscellanea3	Concluding Remarks
Neuropsychology of epilepsy surgery and theory-based practice: an opinion review
Authors: Patrikelis Panayiotis , Messinis Lambros , Kimiskidis Vasileios , Gatzonis Stylianos 
Published: October 2023

AbstractThe present review attempts to discuss how some of the central concepts from the Lurian corpus of theories are relevant to the modern neuropsychology of epilepsy and epilepsy surgery. Through the lenses of the main Lurian concepts (such as the qualitative syndrome analysis), we discuss the barriers to clinical reasoning imposed by quadrant-based views of the brain, or even atheoretical, statistically-based and data-driven approaches. We further advice towards a systemic view inspired by Luria's clinical work and theorizing, given their importance towards our clinical practice, by contrasting it to the modular views when appropriate. Luria provided theory-guided methods of assessment and rehabilitation of higher cortical functions. Although his work did not specifically address epilepsy, his theory and clinical approaches actually apply to the whole neuropathology spectrum and accounting for the whole panorama of neurocognition. This holistic and systemic approach to the brain is consistent with the network approach of the neuroimaging era. As to epilepsy, the logic of cognitive functions organized into complex functional systems, contrary to modular views of the brain, heralds current knowledge of epilepsy as a network disease, as well as the concept of the functional deficit zone.