bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosing Natural Variability of North Atlantic Water Masses in HadCM3
Authors: Haines Keith , Old Chris 
Published: June 2005

Abstract
A study of thermally driven water mass transformations over 100 yr in the ocean component of the Third Hadley Centre Coupled Ocean–Atmosphere General Circulation Model (HadCM3) is presented. The processes of surface-forced transformations, subduction and mixing, both above and below the winter mixed layer base, are quantified. Subtropical Mode Waters are formed by surface heat fluxes and subducted at more or less the same rate. However, Labrador Seawater and Nordic Seawater classes (the other main subduction classes) are primarily formed by mixing within the mixed layer with very little formation directly from surface heat fluxes. The Subpolar Mode Water classes are dominated by net obduction of water back into the mixed layer from below.
Subtropical Mode Water (18°C) variability shows a cycle of formation by surface fluxes, subduction ∼2 yr later, followed by mixing with warmer waters below the winter mixed layer base during the next 3 yr, and finally obduction back into the mixed layer at 21°C, ∼5 yr after the original formation. Surface transformation of Subpolar Mode Waters, ∼12°C, are led by surface transformations of warmer waters by up to 5 yr as water is transferred from the subtropical gyre. They are also led by obduction variability from below the mixed layer, by ∼2 yr. The variability of obduction in Subpolar Mode Waters also appears to be preceded, by 3–5 yr, by variability in subduction of Labrador Sea Waters at ∼6°C. This supports a mechanism in which southward-propagating Labrador seawater anomalies below the subpolar gyre can influence the upper water circulation and obduction into the mixed layer.
A Comparison of SNOTEL and GHCN/CRU Surface Temperatures with Free-Air Temperatures at High Elevations in the Western United States: Data Compatibility and Trends
Authors: Pepin N. C. , Losleben M. , Hartman M. , Chowanski K. 
Published: June 2005

Abstract
This paper compares high-elevation surface temperatures based on the Global Historical Climate Network/Climatic Research Unit (GHCN/CRU) and snow telemetry (SNOTEL) datasets, with simultaneous free-air equivalent temperatures, interpolated from NCEP–NCAR reanalysis. Mean monthly temperature anomalies from 1982 to 1999 are examined for 60 SNOTEL and 296 GHCN/CRU sites at elevations over 500 m with relatively homogenous records. The surface/free-air temperature difference ΔT (Ts − Ta) is calculated for both the SNOTEL and GHCN/CRU datasets. Topography influences the correlation between surface and free-air temperature anomalies. Physically realistic diurnal and seasonal changes in ΔT\E are illustrated. Systematic secular trends in surface temperatures, free-air temperatures, and ΔT are revealed, but the sign and magnitude of change depends on location, meaning that regional signals are weak. The Ts trends are positive for most GHCN and CRU sites, and for SNOTEL sites at night. Daytime cooling in the SNOTEL network reduces the mean daily warming trend. The Ta trends are consistently positive for both networks and are often larger than Ts. Thus mean ΔT trends are negative for both datasets. The smaller sample size in the SNOTEL dataset means that error estimates for regional signals are much wider than for the GHCN/CRU dataset. Trend difference maps identify potentially anomalous SNOTEL records. Trends show no correlation with elevation and topography. Surface trends show higher variability and account for most of the uncertainty in ΔT trends. Sensitivity of trends to time period is also discussed. Such changes in the free-air/surface temperature difference may indicate change in the energy balance of mountain areas.
Role of the Drake Passage in Controlling the Stability of the Ocean’s Thermohaline Circulation
Authors: Sijp Willem P. , England Matthew H. 
Published: June 2005

Abstract
The role of a Southern Ocean gateway in permitting multiple equilibria of the global ocean thermohaline circulation is examined. In particular, necessary conditions for the existence of multiple equilibria are studied with a coupled climate model, wherein stable solutions are obtained for a range of bathymetries with varying Drake Passage (DP) depths. No transitions to a Northern Hemisphere (NH) overturning state are found when the Drake Passage sill is shallower than a critical depth (1100 m in the model described herein). This preference for Southern Hemisphere sinking is a result of the particularly cold conditions of the Antarctic Bottom Water (AABW) formation regions compared to the NH deep-water formation zones. In a shallow or closed DP configuration, this forces an exclusive production of deep/bottom water in the Southern Hemisphere. Increasing the depth of the Drake Passage sill causes a gradual vertical decoupling in Atlantic circulation, removing the influence of AABW from the upper 2000 m of the Atlantic Ocean. When the DP is sufficiently deep, this shifts the interaction between a North Atlantic Deep Water (NADW) cell and an AABW cell to an interaction between an (shallower) Antarctic Intermediate Water cell and an NADW cell. This latter situation allows transitions to a Northern Hemisphere overturning state.
Tropical Atlantic Moisture Flux, Convection over Northeastern Brazil, and Pertinence of the PIRATA Network*
Authors: Durand Bruno , Servain Jacques , Laurent Henri , Machado Luiz A. T. 
Published: June 2005

Abstract
This study aims to examine the relationship between the tropical Atlantic latent heat flux and convective cloud coverage over northeast Brazil (NEB) during the four months of the main rainy season (February–May). The correlation with anomalies of these data is investigated, both without lag and with a 1-month lag (the heat flux in advance). In both cases, a significant positive correlation appears in the northwestern tropical Atlantic, and a significant negative correlation is obtained for a limited area off eastern NEB. These two correlation patterns are linked to anomalies in the trade wind intensity and in the meridional position of the intertropical convergence zone (ITCZ), which relate to the latent heat flux anomalies and NEB convective coverage anomalies, respectively. The positive correlation pattern is spread over a large part of the northern tropical Atlantic, whereas the negative correlation pattern is confined off NEB. This indicates the existence of different regional mechanisms in the tropical Atlantic basin. The impact of the Atlantic heat fluxes on NEB convection is somewhat different from the classical meridional dipole related to the SST variability. The analysis of the horizontal moisture flux shows that during flood years an additional meridional inflow balances the eastward loss, and the upward velocity reinforced over NEB contributes to intensify NEB convection. The positive correlation pattern indicates that the location of the northern branch of the Pilot Research moored Array in the Tropical Atlantic (PIRATA) moorings is pertinent to monitor the ocean–atmosphere interface parameters. The negative correlation pattern off NEB provides new support for the possible extension of the PIRATA array toward the Brazilian coast. Complementary results at 1-month lag and the real-time availability of the PIRATA data confirm the potential of NEB forecasting.
WSR-88D Radar, Tornado Warnings, and Tornado Casualties
Authors: Simmons Kevin M. , Sutter Daniel 
Published: June 2005

Abstract
The impact of the installation of Weather Surveillance Radar-1988 Doppler (WSR-88D) radars in the 1990s on the quality of tornado warnings and occurrence of tornado casualties is examined. This analysis employs a dataset of tornadoes in the contiguous United States between 1986 and 1999. The date of WSR-88D radar installation in each National Weather Service Weather Forecast Office is used to divide the sample. Tornado warnings improved after the installation of Doppler radar; the percentage of tornadoes warned for increased from 35% before WSR-88D installation to 60% after installation while the mean lead time on warnings increased from 5.3 to 9.5 min and the false alarm ratio fell slightly. A regression analysis of tornado casualties, which controls for the characteristics of a tornado and its path, reveals that expected fatalities and expected injuries were 45% and 40% lower for tornadoes occurring after WSR-88D radar was installed in the NWS Weather Forecast Office. This analysis also finds that expected casualties are significantly lower for tornadoes occurring during the day or evening than late at night throughout the sample, which provides indirect evidence of the life-saving effects of tornado warnings.
Multiple sequence alignments of partially coding nucleic acid sequences
Authors: Stocsits Roman R , Hofacker Ivo L , Fried Claudia , Stadler Peter F 
Published: June 2005

Abstract
Background
High quality sequence alignments of RNA and DNA sequences are an important prerequisite for the comparative analysis of genomic sequence data. Nucleic acid sequences, however, exhibit a much larger sequence heterogeneity compared to their encoded protein sequences due to the redundancy of the genetic code. It is desirable, therefore, to make use of the amino acid sequence when aligning coding nucleic acid sequences. In many cases, however, only a part of the sequence of interest is translated. On the other hand, overlapping reading frames may encode multiple alternative proteins, possibly with intermittent non-coding parts. Examples are, in particular, RNA virus genomes.

Results
The standard scoring scheme for nucleic acid alignments can be extended to incorporate simultaneously information on translation products in one or more reading frames. Here we present a multiple alignment tool, codaln, that implements a combined nucleic acid plus amino acid scoring model for pairwise and progressive multiple alignments that allows arbitrary weighting for almost all scoring parameters. Resource requirements of codaln are comparable with those of standard tools such as ClustalW.

Conclusion
We demonstrate the applicability of codaln to various biologically relevant types of sequences (bacteriophage Levivirus and Vertebrate Hox clusters) and show that the combination of nucleic acid and amino acid sequence information leads to improved alignments. These, in turn, increase the performance of analysis tools that depend strictly on good input alignments such as methods for detecting conserved RNA secondary structure elements.
The polymorphic nature of the human dopamine D4 receptor gene: A comparative analysis of known variants and a novel 27 bp deletion in the promoter region
Authors: Szantai E , Szmola R , Sasvari-Szekely M , Guttman A , Ronai Z 
Published: June 2005

Abstract

Background
The human dopamine D4 receptor (DRD4) is a candidate gene of great interest in molecular studies of human personality and psychiatric disorders. This gene is unique in having an exceptionally high amount of polymorphic sites both in the coding and in the promoter region.

Results
We report the identification of a new 27 bp deletion starting 524 bp upstream of the initiation codon (27 bp del) of the dopamine D4 receptor (DRD4) gene, in the close vicinity of the -521C>T SNP. The presence of the 27 bp deletion leads to the misgenotyping of the -616C>G SNP by the Sau 96 I RFLP method, thus the genotype determination of the mutation is of additional importance. The frequency of this novel sequence variation is considerably low (allele frequency is = 0.16%), as no homozygotes, and only 3 heterozygote carriers were found in a healthy, unrelated Caucasian sample (N = 955).

Conclusion
Remarkably, the deleted region contains consensus sequences of binding sites for several known transcription factors, suggesting that the different alleles may affect the transcriptional regulation of the gene. A comparison of methods and results for the allelic variations of the DRD4 gene in various ethnic groups is also discussed, which has a high impact in psychiatric genetic studies.
A cluster randomized trial to assess the impact of opinion leader endorsed evidence summaries on improving quality of prescribing for patients with chronic cardiovascular disease: rationale and design [ISRCTN26365328]
Authors: Majumdar Sumit R , McAlister Finlay A , Tsuyuki Ross T 
Published: June 2005

Abstract

Background
Although much has been written about the influence of local opinion leaders on clinical practice, there have been few controlled studies of their effect, and almost none have attempted to change prescribing in the community for chronic conditions such as heart failure (HF) or ischemic heart disease (IHD). These two conditions are common and there is very good evidence about how to best prevent morbidity and mortality – and good evidence that quality of care is, in general, suboptimal. Practice audits have demonstrated that about one-half of eligible HF patients are prescribed ACE inhibitors (with fewer still reaching appropriate target doses) and less than one-third of patients with established IHD are prescribed statins (with many fewer reaching recommended cholesterol targets). It is apparent that interventions to improve quality of prescribing are urgently needed. We hypothesized that an intervention that consisted of patient-specific one-page evidence summaries, generated and then endorsed by local opinion leaders, would be able to change prescribing practices of community-based primary care physicians.

Methods (study design)
A pragmatic single-centre cluster randomized controlled trial comparing an opinion leader-based intervention to usual care for patients with HF or IHD. Randomization will be clustered at the level of the primary care physician; as the design effect is anticipated to be negligible, the unit of analysis will be the patient. Patients with HF or IHD (not receiving ACE inhibitors or statins, respectively) will be recruited from community pharmacies and allocated to intervention or usual care based on the randomization status of their primary care physician. The primary outcome is improvement in prescription of proven efficacious therapies for HF (ACE inhibitors) or IHD (statins) within 6 months of the intervention.

Conclusion
If the methods used in this intervention are found to improve prescribing practices, similar interventions could be designed for other chronic conditions dealt with in the outpatient setting.
Retinopathy of prematurity and risk factors: a prospective cohort study
Authors: Karna Padmani , Muttineni Jyotsna , Angell Linda , Karmaus Wilfried 
Published: June 2005

Abstract
Background
Increased survival of extremely low birth infants due to advances in antenatal and neonatal care has resulted in a population of infants at high risk of developing retinopathy of prematurity (ROP). Therapeutic interventions include the use of antenatal and postnatal steroids however, their effects on the severity of ROP is in dispute. In addition, it has not been investigated whether severe ROP is due to therapeutic interventions or due to the severity of illness. The aim of the present study was to assess the association between the incidence of severe retinopathy of prematurity (greater than stage 2 – International classification of ROP) and mechanical ventilation, oxygen therapy, gestational age, antenatal and postnatal steroids in extremely low birth weight infants.

Methods
Neonates admitted to the neonatal intensive care unit in Lansing, Michigan, during 1993–2000 were followed to determine factors influencing the development of severe retinopathy of prematurity. Ophthalmologic examinations were started at 6 weeks and followed until resolution. We used logistic regression to estimate the relative risk (odds ratio) associated with risk factors of ROP.

Results
Of the neonates with ≤ 1500 g birth weight, admitted to the neonatal intensive care unit, 85% (616/725) survived. Severe retinopathy of prematurity was detected in 7.8% of 576 neonates who had eye examinations. Neonates of lower gestational age (≤ 25 weeks and 26–28 weeks) had an increased odds ratio of 8.49 and 3.19 for the development of severe retinopathy of prematurity, respectively, compared to those 29 weeks and older. Late postnatal steroid treatment starting after 3 weeks of life showed 2.9-fold increased odds ratio, in particular administration for two weeks and more (OR: 4.09, 95% CI: 1.52–11.03). With increasing antenatal steroids courses the risk of severe retinopathy of prematurity decreased, however, it was not significant. Lower gestational age, dependence on ventilation, and use of postnatal steroids were intertwined. Simultaneous presence of these factors seems to indicate severe disease status.

Conclusion
Prolonged and late postnatal steroids treatment in very low birth weight infants may pose an increased risk for the development of severe retinopathy of prematurity; however, use of postnatal steroids may also be a marker for severity of illness. Further studies need to focus on biologic markers in the pathogenesis of retinopathy of prematurity and to better understand the influence of therapies.
Top 10 health care ethics challenges facing the public: views of Toronto bioethicists
Authors: Breslin Jonathan M , MacRae Susan K , Bell Jennifer , Singer Peter A ,   the University of Toronto Joint Centre for Bioethics Clinical Ethics Group
Published: June 2005

Abstract
Background
There are numerous ethical challenges that can impact patients and families in the health care setting. This paper reports on the results of a study conducted with a panel of clinical bioethicists in Toronto, Ontario, Canada, the purpose of which was to identify the top ethical challenges facing patients and their families in health care. A modified Delphi study was conducted with twelve clinical bioethicist members of the Clinical Ethics Group of the University of Toronto Joint Centre for Bioethics. The panel was asked the question, what do you think are the top ten ethical challenges that Canadians may face in health care? The panel was asked to rank the top ten ethical challenges throughout the Delphi process and consensus was reached after three rounds.

Discussion
The top challenge ranked by the group was disagreement between patients/families and health care professionals about treatment decisions. The second highest ranked challenge was waiting lists. The third ranked challenge was access to needed resources for the aged, chronically ill, and mentally ill.

Summary
Although many of the challenges listed by the panel have received significant public attention, there has been very little attention paid to the top ranked challenge. We propose several steps that can be taken to help address this key challenge.
Distribution of immunodeficiency fact files with XML – from Web to WAP
Authors: Väliaho Jouni , Riikonen Pentti , Vihinen Mauno 
Published: June 2005

Abstract
Background
Although biomedical information is growing rapidly, it is difficult to find and retrieve validated data especially for rare hereditary diseases. There is an increased need for services capable of integrating and validating information as well as proving it in a logically organized structure. A XML-based language enables creation of open source databases for storage, maintenance and delivery for different platforms.

Methods
Here we present a new data model called fact file and an XML-based specification Inherited Disease Markup Language (IDML), that were developed to facilitate disease information integration, storage and exchange. The data model was applied to primary immunodeficiencies, but it can be used for any hereditary disease. Fact files integrate biomedical, genetic and clinical information related to hereditary diseases.

Results
IDML and fact files were used to build a comprehensive Web and WAP accessible knowledge base ImmunoDeficiency Resource (IDR) available at http://bioinf.uta.fi/idr/. A fact file is a user oriented user interface, which serves as a starting point to explore information on hereditary diseases.

Conclusion
The IDML enables the seamless integration and presentation of genetic and disease information resources in the Internet. IDML can be used to build information services for all kinds of inherited diseases. The open source specification and related programs are available at http://bioinf.uta.fi/idml/.
Fusion von Sensordaten am Beispiel von Sicherheitsanwendungen in der Automobiltechnik (Sensor Data Fusion for Safety Applications in Automotive Environment)
Authors: Skutek Michael , Linzmeier Dirk 
Published: June 2005

Abstract
Der Artikel beschreibt unterschiedliche Ansätze zur Fusion von Sensordaten beispielhaft an zwei Sicherheitsanwendungen im Automobilbereich – PreCrash und Fußgängererkennung. Der Fokus liegt nicht ausschließlich auf der Fusionstheorie selbst; auch die Anforderungen der Anwendungen und die sensortechnischen Voraussetzungen sind dargestellt.
Für die PreCrash-Funktion werden zwei Ansätze zur Fusion von Radarsensoren und einem Laserscanner vorgestellt. Das Fußgängerdetektionssystem besteht aus einer Anordnung von Thermopile-Sensoren, die zur Bestimmung der Fußgängerposition fusioniert werden.
The Health of Poor Women Under Welfare Reform
Authors: Kaplan George A. , Siefert Kristine , Ranjit Nalini , Raghunathan Trivellore E. , Young Elizabeth A. , Tran Diem , Danziger Sandra , Hudson Susan , Lynch John W. , Tolman Richard 
Published: June 2005

Objectives. We compared the health of single mothers affected by welfare reform with the health of a nationally representative sample of women to document the prevalence of poor health as single mothers experience the effects of welfare reform. Methods. We compared risk factors and measures of health among women randomly sampled from the welfare rolls with similar data from a nationally representative sample of women. Results. Women in our welfare recipient sample had higher rates of elevated glycosylated hemoglobin (≥ 6%; prevalence ratio [PR]=4.87; 95% confidence interval [CI]=2.69, 7.04), hypertension (systole ≥ 140 or diastole ≥ 90; PR=2.36; 95% CI = 1.47, 3.24), high body mass index ( ≥ 30; PR = 1.78; 95% CI = 1.49, 2.08), and high-density lipoprotein cholesterol (≤ 35 mg/dL; PR=1.91; 95% CI=1.17, 2.65); lower peak expiratory flow; and less physical functioning. Current smoking rates were higher (PR = 1.85; 95% CI = 1.50, 2.19) and smoking cessation rates were lower (PR=0.62; 95% CI=0.37, 0.86) than in the national sample. Conclusions. Current and former welfare recipients bear a substantial burden of illness. Further studies are necessary to interpret our findings of worsened health in the wake of welfare reform.
Childhood Socioeconomic Position, Educational Attainment, and Adult Cardiovascular Risk Factors: The Aberdeen Children of the 1950s Cohort Study
Authors: Lawlor Debbie A , Batty G. David , Morton Susan M.B. , Clark Heather , Macintyre Sally , Leon David A. 
Published: June 2005

Objectives. We assessed the associations of childhood socioeconomic position with cardiovascular disease risk factors (smoking, binge alcohol drinking, and being overweight) and examined the roles of educational attainment and cognitive functioning in these associations. Methods. Data were derived from a cohort study involving 7184 individuals who were born in Aberdeen, Scotland, between 1950 and 1956; had detailed records on perinatal characteristics, childhood anthropometry, and cognitive functioning; and responded to a mailed questionnaire when they were aged 45 to 52 years. Results. Strong graded associations existed between social class at birth and smoking, binge drinking, and being overweight. Adjustment for educational attainment completely attenuated these associations. However, after control for adult social class, adult income and other potential confounding or mediating factors, some association remained. Conclusions. Educational attainment is an important mediating factor in the relation between socioeconomic adversity in childhood and smoking, binge drinking, and being overweight in adulthood.