bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three cannabis products attenuated oxaliplatin-induced peripheral neuropathy by inhibiting proteins that mediate oxaliplatin transport.
Authors: Sun Kaiyu , Wu Yuliu , Yan Xiaoqi , Tong Xu , Liu Yuanyuan , Song Yanping , Li Jinlian , WU DONGMEI 
Published: October 2023

Abstract
Oxaliplatin induced peripheral neuropathy (OIPN) has greatly limited its clinical application. The aim of this study was to investigate whether three plant cannabinoid products could reduce OXA-induced peripheral neurotoxicity by selectively inhibiting OXA uptake transporter expression. The results showed that the three cannabinoid products with CBD as the main component could effectively inhibit the expression of transporter OCT2/OCTN1/OCTN2, thereby reducing the platinum content in DRG and inhibiting OIPN. And promote the anti-tumor effect of OXA. Among them, full spectrum CBD containing 0.3%THC and other secondary cannabinoids has the most significant therapeutic effect, and the safe therapeutic dose range is wider. These results suggest that CBD down-regulates the expression of OXA transporter and inhibits the main component of OIPN. The addition of THC and other secondary cannabinoids can overcome the dose limitation of purified CBD and exert more significant therapeutic effect in synergy with CBD.
Colorant extraction from turmeric (Curcuma Longa L) and optimization of its application on chrome-free tanned paiche (Arapaima gigas) leather
Authors: MARRUFO-SALDAÑA LILIANA , SUELDO-ROJAS HENRY , CONTRERAS-PANIZO ROSA , SEGUNDO-ESPADA MÁXIMO , BARRA-HINOJOSA JULIO , BULEJE-DEL-CARPIO ROBERT , CHUNGA-CHUNGA WILMER , LAURA-TITO MISAEL 
Published: October 2023

Abstract
The tanning of paiche skins represents an opportunity to give added value to waste generated in aquaculture. It requires clean technologies, as the substitution of highly-toxic chemicals. Basic chromium sulfate, a tanning agent used because of the physical-mechanical and thermal properties it imparts to leather, and synthetic dyes, including azo compounds, are among the most toxic but important products in the process. This research aimed to obtain a natural colorant from Curcuma Longa L. for dyeing paiche skins tanned with phenolic-syntans and glutaraldehyde compounds. Curcumin, the coloring principle, was extracted from turmeric rhizomes in aqueous medium, and characterized by HPLC-DAD and UV-visible spectrophotometry, and its response to variations in temperature, time, and mass of turmeric was evaluated at the laboratory level. Subsequently, a Box-Behnken design was established to optimize dyeing at the pre-pilot level. The factors studied were dyeing time (x1), turmeric colorant concentration (x2) and mordant concentration (x3), while response variable was the Color Intensity of dyed leather (y1). Through ANOVA analysis, the main effects and behavior of the response variable were determined. Process was scaled-up to the pilot level at the optimal point, evaluating chemical, mechanical, and colorfastness properties of leather. Results indicate the extraction of curcumin increases with temperature and the mass of turmeric. Optimal process values were 100.5 minutes, 5.06 % colorant, and 13.20 % mordant. Chemical and mechanical results suggest that leather is suitable to produce footwear, clothing, and leather goods; however, it is necessary to improve its lightfastness.
The impact of wind speed measurement method on MRT and UTCI values ​​in limited air flow conditions within urban green areas.
Authors: Lindner-Cendrowska Katarzyna , Kuchcik Magdalena 
Published: October 2023

Abstract
Wind speed is an important variable in the assessment of thermal comfort. Different types of meteorological devices provide different accuracy of air velocity (va) measurements, what under limited air flow conditions, may result in an underestimation of actual thermal stress level. Simultaneous measurements on warm summer days, performed with a cup anemometer and hot-wire probe, prove that too high starting threshold of the first of these sensors can lead to underestimation of actual wind speed, and as a consequence can distort MRT (estimated with globe thermometer) and UTCI values ​​up to 10°C and 2°C respectively.
The great gerbil (Rhombomys opimus) as a host for tick species in Gurbantunggut desert
Authors: Liu Gang , Tan Wenbo , Han Xiaoshuang , Hornok Sándor , Zhao Shanshan , Mi Ligu , Wang Suwen , Yang Meihua , Wang Yuanzhi 
Published: October 2023

Abstract
Background
Rodents play an important role in the life cycle of ixodid and argasid ticks, particularly as hosts of larvae and nymphs. The great gerbil (Rhombomys opimus), the preferred prey item of several carnivores (e.g., the red fox and the marbled polecat), is the dominant rodent species in the Gurbantunggut Desert, in northwestern China. The aim of this study was to investigate tick species associated with different hosts in the habitat of great gerbils, including wildlife and livestock.
Methods
During 2018–2023, ticks were removed from 326 great gerbils (Rhombomys opimus), two red foxes (Vulpes vulpes), three marbled polecats (Vormela peregusna), 35 pastured sheep (Ovis aries), and one long-eared desert hedgehog (Hemiechinus auritus) in the Gurbantunggut Desert. Ticks were identified according to standard morphological keys. Then they were further analyzed by molecular and phylogenic methods based on two mitochondrial markers, the 16S rDNA and the cytochrome c oxidase subunit I (COI) genes.
Results
A total of 889 ticks were collected, representing five species. These included Hyalomma asiaticum (n = 425: 24 larvae, 79 nymphs and 322 adults), Rhipicephalus turanicus (n = 153: 2 nymphs and 151 adults), Haemaphysalis erinacei (n = 298: 4 larvae, 7 nymphs and 287 adults), Ixodes acuminatus (n = 7: 4 nymphs and 3 adults) and Ornithodoros tartakovskyi (6 adults). Based on COI sequences, molecular and phylogenetic analyses showed that i) I. acuminatus from great gerbils and marbled polecats clustered with I. acuminatus reported from Europe; ii) O. tartakovskyi found in northwestern China belonged to an independent clade; and iii) Hy. asiaticum, R. turanicus and Ha. erinacei had 100% sequence identities to conspecific ticks sampled previously in China.
Conclusions
The great gerbil is an important host for the developmental stages of I. acuminatus, O. tartakovskyi, Ha. erinacei, Hy. asiaticum and R. turanicus, thus supporting the life cycle of several tick species which, as adults, parasitize predators (the red fox and the marble polecat), as well as pastured sheep and hedgehogs in the Gurbantunggut Desert. Ixodes acuminatus and O. tartakovskyi were found for the first time on great gerbil and marbled polecat, respectively.
Adsorption and migration of lithium ions on the surface of C 3 N under electric field
Authors: Wang Li , Bai Hongyu , Zheng Xichen , Yin Chaofan , Qin Feng , Geng ShangRui , Dong Binbin 
Published: October 2023

Abstract
The nitrogen-doped graphene (C3N) had special physical and chemical properties, thus it was widely used in various fields, especially as a lithium-ion batteries (LIBs) anode material. However, the electric field was one of the important factors affecting the performance of C3N as an anode electrode material for LIBs. Consequently, in this work, first-principal calculations were adopted to investigate the adsorption and migration properties of lithium ions on C3N surface by electric field. Calculation results show that the C3N monolayer exhibited a narrower band gap (0.0191eV) and lower diffusion barrier (0.107 eV) under the application of the electric field, and the negative value of the adsorption energy increased by degrees with the increase of the electric field. Bader charge analysis and charge density difference calculations also provided forceful evidence for the ability of C3N to adsorb lithium ions. As a result, our theoretical results demonstrated that C3N should be a new type of anode material for LIBs.
Prenatal diagnosis of patent urachus by demonstrating bi-directional flow from the bladder
Authors: PEKAR-ZLOTIN Marina , Zmora Osnat , Maymon Ron , Svirsky Ran 
Published: October 2023

Abstract
Patent urachus connects the urinary bladder with the umbilicus and is an intra-abdominal portion of the allantois duct. In most cases, the urachus obliterates at approximately six weeks of gestation. The prenatal diagnosis of patent urachus is rare and can lead to both maternal and physician anxiety. Here in we present a case of prenatal diagnosis of open urachus by demonstrating a bi-directional flow from the bladder to both the penis and the urachus and its outcome.
Elevated Blood Urea Nitrogen to Serum Albumin Ratio Is an Adverse Prognostic Predictor for Septic shock in Intensive Care Units
Authors: Hu Hai , He Dan , Qiu Minshan , Tan Wupeng , Liu Lingyan , Liu Shuai , Guo Youqiao , lyu Jun , Yin Haiyan 
Published: October 2023

Abstract
BACKGROUND Septic shock is a life-threatening subset of sepsis, and blood urea nitrogen (BUN) and serum albumin are inexpensive and easily available biomarkers. BUN to serum albumin ratio (BAR) has been identified as a valuable prognostic marker in various diseases. Therefore, we conducted a retrospective study to explore the relationship between BAR and mortality risk in septic shock.
METHODS From 2008 to 2019, we enrolled 3, 220 patients diagnosed with septic shock from the MIMIC-IV database. Restricted cubic spline (RCS) was used to visualize the relationship between BAR and mortality. Kaplan-Meier survival curves were generated to evaluate differences in survival rates among three groups: low-BAR (<9.6), medium-BAR (≥9.6, <20.0), and high-BAR (≥20.0). Box plot analysis was performed to compare the distribution of BAR between survivors and non-survivors. Cox regression analysis was used to estimate the independent association between BAR and all-cause mortality. The receiver operating characteristic (ROC) curve analysis was conducted to assess the performance of BAR for predicting mortality.
RESULTS The mean age was 66.1 years. The 28-day mortality risk increased non-linearly with BAR values as shown by RCS. Compared to the low-BAR or medium-BAR group, the high-BAR group had significantly higher mortality according to Kaplan-Meier curves for in-hospital, 28-day, 90-day, and 1-year mortalities. The boxplot demonstrated that patients who survived had lower BAR compare to non-survived in terms of in-hospital, 28-day, 90-day, and 1-year. The results of both the univariate and multivariate Cox regression analysis showed that BAR was an independent risk factor for predicting in-hospital, 28-day, 90-day, and 1-year mortalities, with higher BAR values associated with increasing mortality.
For sensitivity analysis, the Cox regression analysis also showed that compared with the low-BAR group, the high-BAR group had a higher risk of in-hospital, 28-day, 90-day, and 1-year mortality rates in both the unadjusted and adjusted models.
Conclusions The study showed that BAR was an independent risk factor for predicting both short-term and 1-year mortality rates in septic shock patients.
Development of a Chemiluminescence Assay for Tissue Plasminogen Activator Inhibitor Complex and Its Applicability to Gastric Cancer
Authors: Ji Yu , Qin Yan , Tan Qi , Qiu Yanru , Han Shuang , Qi Xiaowei 
Published: October 2023

Abstract

Background: Venous thromboembolism (VTE), is a noteworthy complication in individuals with gastric cancer, but the current diagnosis and treatment methods lack accuracy. In this study, we developed a t-PAIC chemiluminescence kit and employed chemiluminescence to detect the tissue plasminogen activator inhibitor complex (t-PAIC), thrombin-antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC) and thrombomodulin (TM), combined with D-dimer and fibrin degradation products (FDP), to investigate their diagnostic potential for venous thrombosis in gastric cancer patients. The study assessed variations in six indicators among gastric cancer patients at different stages.
Results: The t-PAIC reagent showed LOD is 1.2 ng/mL and a linear factor R greater than 0.99. The reagents demonstrated accurate results, with all accuracy deviations being within 5%. The intra-batch and inter-batch CVs for the t-PAIC reagent were both within 8%. The correlation coefficient R between this method and Sysmex was 0.979. Gastric cancer patients exhibited elevated levels of TAT, PIC, TM, D-D, FDP compared to the healthy population, while no significant difference was observed in t-PAIC. In the staging of gastric cancer, patients in Ⅲ-Ⅳ stages exhibit higher levels of the six markers compared to those in Ⅰ-Ⅱ stages. The ROC curve indicates an enhancement in sensitivity and specificity of the combined diagnosis of four or six indicators.
Conclusion: Our chemiluminescence assay performs comparably to Sysmex’s method and at a reduced cost. The use of multiple markers, including t-PAIC, TM, TAT, PIC, D-D, and FDP, is superior to the use of single markers for diagnosing VTE in patients with malignant tumors. Gastric cancer patients should be screened for the six markers to facilitate proactive prophylaxis, determine the most appropriate treatment timing, ameliorate their prognosis, decrease the occurrence of venous thrombosis and mortality, and extend their survival.
Origin of current intermediate wheatgrass germplasm being developed for Kernza grain production
Authors: Wagoner Peggy , Crain Jared , Larson Steve , DeHaan Lee 
Published: October 2023

Abstract
Intermediate wheatgrass (IWG, Thinopyrum intermedium [Host] Barkworth & D. R. Dewey) has been developed as a perennial grain crop to provide ecosystem services, environmental benefits, and human food. Grain and products derived from IWG varieties improved for food production have been marketed under the registered trademark, Kernza. In the 1980s, a joint breeding effort between the Rodale Institute (RI) and the Big Flats Plant Material Center used IWG plant introductions (PI) from the National Plant Germplasm System (NPGS) and recurrent phenotypic selection to improve populations of IWG with the goal of developing a perennial grain. Initial selections were provided to The Land Institute where they were subsequently improved for grain production, yet the identity of the founder material of improved, food-grade IWG has not been publicly documented. Recently recovered original documents have been used to reconstruct the early breeding program to identify the most likely 20 PIs that form the founders of modern food-grade IWG. Molecular data using genotyping-by-sequencing in current elite breeding material, remnant seed from the initial RI selections, and preserved sample material have provided supporting evidence for the historical records. The genetic origin for food-grade IWG is focused between the Black Sea and Caspian Sea in the Stavropol region of Russia, with smaller contributions likely from collections as distant as Kazakhstan in the east to Turkey in the west. This work connects the flow of germplasm and utility of NPGS PIs to present day IWG grain cultivars being developed in multiple breeding programs around the world.
Availability of the current and future water resources in Equatorial Central Africa, case of the Nyong forest catchment in Cameroon
Authors: Ebodé Valentin Brice , Onana Ngono , Dzana Jean Guy , Amougou Joseph Armathé , Batha Romain Armand Soleil , Boyomo Thomas , Mbeih Ndjela 
Published: October 2023

Abstract
To anticipate disasters (drought, floods, etc.) caused by environmental forcing and reduce their impacts on its fragile economy, sub-Saharan Africa needs a good knowledge of the availability of current water resources and reliable hydroclimatic forecasts. This study has as objective to quantify the availability of water resources in the Nyong basin and predict its future evolution (2024–2050). For this, the SWAT (Soil and Water Assessment Tool) model was used. The performance of this model is satisfactory in calibration and validation, with R2, NSE and KGE greater than 0.64. Biases lower than − 14% also attest to this good performance. In the investigated basin, infiltration (GW_RCH), evapotranspiration (ETP), runoff (SURQ) and water yield (WYLD) are greater in the East, probably due to more abundant rainfall in this part. The flows and sediment load (SED) are greater in the middle zone and in the Southwest of the basin, certainly because of the relief of this part, which corresponds to the valley floor. Two models (CCCma and REMO) predict a decline in water resources in this basin, and two others (HIRHAM5 and RCA4) the opposite. However, based on a statistical study carried out over the historical period (2001–2005), the CCCma model seems the most reliable. It forecasts a drop in precipitation and runoff, which do not exceed − 19% and − 18%, respectively, whatever the emission scenario (RCP4.5 or RCP8.5). Climate variability (CV) is the only forcing whose impact is visible in the dynamics of current and future flows, due to the modest current and future changes observed in the evolution of land use and land cover (LULC). The results of this study could contribute to improving water resource management in the basin studied and the region.
Applications of 3D printing in orthopedics: A scoping review
Authors: Onggo Jason Derry , Fong Francis Jia Yi , Munro Yasmin Lynda , Yam Michael Gui Jie 
Published: October 2023

Abstract
Purpose
In light of increasing adoption of 3D printing in clinical practice, this review aims to provide an updated overview on the current applications of 3D printing in orthopaedics and identify the gaps in existing literature.
Methods
Electronic database search of PubMed, Embase, Ovidmedline, Cochrane Library and Cumulative Index to Nursing & Allied Health Literature was performed on 7 April 2023, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines for scoping reviews. The searches were conducted using the keywords relating to “orthopaedic” and “three-dimensional printing”. No restrictions were placed on the date of publication.
Results
1333 articles were included in the final synthesis of this review. 6 main themes were identified: surgical planning (57.01%), implants (28.73%), prostheses (5.03%), surgical training and education (4.20%), orthosis (3.98%) and patient education (1.05%). Specialties which commonly used 3D-printing included trauma, spine and adult reconstruction. Common anatomical sites included pelvis, spine and knee. Titanium was the most used material, followed by polylactic acid and resin. Titanium was predominantly used in 3D printed implants while polylactic acid and resin were predominantly used during surgical planning. There was a paucity of literature pertaining to legal and economical papers.
Conclusion
Existing literature demonstrates the growing applications of 3D printing in orthopaedics with the potential for it to address the needs of low-income countries, improve patient outcomes and enhance surgical practices. However, further research is needed to explore the clinical, economic aspects and optimization of workflow to establish 3D printing as a standard of care in orthopaedics.
Comprehensive Pancancer Analysis of TUBB6 as a Marker for Prognosis and Immunotherapy Response
Authors: YANG CHI , LEI QINGJUN , HU YAN , YI KE , SUN XUAN , XU XIAOHUI 
Published: October 2023

Abstract
Background TUBB6 is a member of the β-tubulin gene family. However, its prognostic value and involvement in immune response remain unclear to date. Here, we assessed the function of TUBB6 in pancancer.Methods We utilized The Cancer Genome Atlas database, to explore the expression levels and prognosis of TUBB6 in pancancer. Using the cBioPortal and TCGA databases, we assessed immune, mutation, methylation and drug sensitivity of TUBB6. We further used the GeneMANIA and CancerSEA to explore its molecular function. Subsequently, TUBB6 overexpression was to determine its function on COAD in vitro.Results The results revealed intriguing patterns of TUBB6 expression in different tumor types. TUBB6 levels positively correlated with pathological stage, N stage, and T stage in many cancers. Patients with TUBB6 overexpression in many cancers had poor prognosis. Moreover, we found that TUBB6 expression was positively correlated with TME constituents and DNA methylation in most tumors. In addition, single-cell analysis and GSEA revealed that TUBB6 participates in EMT, hypoxia, and angiogenesis in many cancers. Furthermore, TUBB6 overexpression significantly inhibited cell proliferation, and cycle.Conclusion TUBB6 participates in the immune infiltration and the prognosis in multiple cancers. These findings suggest that TUBB6 may be a latent prognostic biomarker and immunotherapy target for tumors.
Control Strategies for Energy Enhancement of LDR and GPS based PV System under Varying Weather Conditions
Authors: Kumar Kanhaiya , Varshney Lokesh , Varshney Geetika , Vardhan Aanchal Singh S. 
Published: October 2023

Abstract
Energy harvesting tests have been piloted in the experiment paper using a static base Photovoltaic (PV) configuration and a two-orientation Sun follower module with ten watt solar panels. The sun follower arrangement in the global positioning system (GPS) is designed to ensure the best potential power output from solar radiation. By tracing the sun’s trajectory across the sky over the course of the day, the GPS-based two-orientation sun following system has been able to record sunlight intensity from 6:00 to 18:30 solar time. The sun follower module with GPS has a higher engrossed power than the Light Dependent Resister (LDR) based two-axis follower and the static base panel, with the average energy generation on a sunny, hazy, foggy, or rainy day being 146.7Wh, 82.45Wh, and 42.79Wh, respectively. The solar panel used here is flexible and use 15 • of step tracking to reduce syste power consumption. In 2021, the average amount of 1 energy produced by the two-axis-GPS sun following system was 4.021754Wh/-day, 45.85% more than the average amount of energy produced by the LDR (22% to 35%) and static base PV system.
The safety and feasibility of Hand-Assisted Laparoscopic technology in splenectomy
Authors: Chen Wenhui , Huang Xianyu , Liao Yonghui , Dai Qixin , zhong dingwen 
Published: October 2023

Abstract
Background laparoscopic splenectomy (LS) has been reported as a safe, minimally invasive surgery. The hand-assisted laparoscopic splenectomy (HALS) approach overcomes the drawbacks of LS with added advantages. We aimed to compare the safety and feasibility of HALS and LS.Method We retrospectively collected patients who underwent HALS or LS from January 2019 to December 2022 at the Department of Hepatobiliary and Pancreatic Surgery, Ganzhou People’s Hospital, Nanchang University. Demographic characteristics and perioperative variables related to HALS or LS were collected, and the clinical outcomes were compared between the two groups.Results Between January 2019 to December 2022, 62 patients who underwent HALS (n = 35) and LS (n = 27) were collected in this study. There were no conversions to open surgery in the HALS group during surgery. HALS showed significantly better results with respect to shorter operative time (P < 0.001), postoperative hospital stay (P < 0.001), faster food intake (P = 0.04), and less estimated blood loss (P = 0.01). There was no significant difference between the two groups in terms of overall complication. Ninety-day mortality was not observed among the patients.Conclusion This study showed that hand-assisted laparoscopic splenectomy is safe, feasible, and effective. It deserves to be widely accepted, especially in emergency surgery for splenic rupture.