bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unleashing Thermal Potential: Successes and Challenges in Steam Injection Well Completions for Thermally Assisted GOGD Heavy Oil Field
Authors: Nofali N. , Amri M. , Shaibani M. , Vandeweijer T. , Diri M. 
Published: November 2023

Abstract
Field-X is a heavily naturally fractured carbonate reservoir with viscous and sour oil. The recovery mechanism employed is thermally assisted gas oil gravity drainage (TA-GOGD), featuring a unique combination of a gas cap and strong aquifer influx—making it the first and only of its kind worldwide. The objective of this paper is to showcase the success stories and challenges associated with steam injection well completions in this unique and challenging producing environment. The focus is on the entire well completion process, including design, installation, remedial interventions, and operation, with a specific emphasis on maintaining well integrity and meeting field steam injection targets.
Real case studies are presented, highlighting the success stories and challenges of steam injection well completions in Field-X. The improvements made in completion design are discussed, ranging from injection through cemented casing to sophisticated completions, and the challenges encountered with each design are also emphasized. Additionally, the learnings and challenges during the workover interventions using well pulling hoist (WPH) or wireline unit (WLU) are highlighted. Furthermore, operational philosophy and best practices for well integrity are presented, drawing on cumulative field experience.
The Improved completion design has resulted in enhanced injection performance, improved well integrity, and consequently increased oil recovery and production. However, emerging issues that require further attention and mitigation are also identified. Additionally, the paper concludes by highlighting valuable lessons learned and providing recommendations concerning steam injection well interventions and operational strategies. Real case studies and valuable guidance are offered for optimizing steam injection well completions, contributing to the understanding of optimizing thermal recovery in similar carbonate reservoirs.
Recombinant Bacillus subtilis for Enhanced Production of High Molecular Weight Hyaluronic Acid
Authors: Doumbouya Nouhan , Akkaya Alper 
Published: November 2023

Abstract
This study aimed to synthesize hyaluronic acid (HA) using a non-pathogenic, recombinant bacterial host, specifically Bacillus subtilis 1A752. The hyaluronic acid synthase (HAS) gene, hasA, originally isolated from Streptococcus equi subsp. zooepidemicus, was introduced into B. subtilis 1A752. This host strain already harbors tuaD, gtaB, and gcaD genes, which are functional analogues to the Streptococcus genes hasB, hasC, and hasD, respectively. The hasA operon was amplified from genomic DNA of S. zooepidemicus through polymerase chain reaction (PCR) and subsequently cloned into B. subtilis 1A752 using recombinant DNA technology. The engineered B. subtilis strain was then utilized for HA production. Post-synthesis, HA was analyzed and deproteinized using Carbazole and Sevag methods, respectively. The purified HA was characterized using chromatographic techniques, and its molecular structure was confirmed through Nuclear Magnetic Resonance (NMR) and Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) spectroscopy. Viscosimetric methods were employed to determine the HA's characterization and molecular weight. The results revealed that the engineered B. subtilis 1A752 strain could produce HA at a concentration of 195.45 mg. l-1, with molecular weights ranging from 1.7 to 2.7 MDa. Given its high molecular weight and non-pathogenic production source, the synthesized HA shows promising potential for applications in the pharmaceutical and biomedical industries.
Precision Nursing Research Based on Multimodal Knowledge Graph
Authors: Xiong Liping , Zeng Qiqiao , Deng Wuhong , Luo Weixiang , Liu Ronghui 
Published: November 2023

Abstract
Background: Precision nursing seeks to tailor care to individual patient needs, and knowledge graphs offer a promising way to integrate diverse data for enhanced precision. However, the application of knowledge graphs in nursing remains relatively unexplored, motivating this study.
Objective: This study aims to explore and apply multimodal knowledge graph technology to facilitate the development of precision nursing, providing patients with more efficient, accurate, and personalized care services.
Methods: Firstly, we collected and integrated data sources, including clinical databases, nursing training textbooks, and internet data, to form a multimodal dataset in the field of nursing. Then, we used natural language processing techniques, data mining algorithms, and graph database technology to extract and represent knowledge from different data sources, constructing a nursing multimodal knowledge graph containing textual, image, and video data. After completing the graph construction, we used visualization tools to display and interactively query the graph to validate its accuracy and utility.
Results: We have built a multimodal knowledge graph in the nursing domain, focusing on patients and diseases, and highlighting nursing issues, nursing techniques, nursing assessments, and disease symptoms. This comprehensive multimodal knowledge graph encompasses a total of 62,909 entities and 330,285 relationships. We have effectively applied this graph in precision nursing research, yielding favorable outcomes in the domains of personalized nursing profiles generation, clinical nursing semantic search, real-time nursing question-answering, and personalized nursing decision-making.
Conclusions: This study demonstrates the value and potential applications of multimodal knowledge graph in precision nursing research. The graph provides comprehensive and precise knowledge support for nursing education, clinical practice, and decision-making, and holds the promise of further advancing and innovating nursing informatization and intelligence. And our code and databases can be accessed through the link: https://github.com/XiongLP208/NursingKnowledgePN .
Identification of a seven-gene prognostic model for kidney renal cell carcinoma associated with CD8+T lymphocyte cell
Authors: Liu Jing bang , Yin Bo 
Published: November 2023

Abstract

CD8 + T lymphocytes are important elements of the tumor immune microenvironment (TIME), hence their involvement in the development and progression of tumors is complex. Data on the precise tumor-infiltrating immune cells (TIICs) gene signature in kidney cancer (KIRC) remain limited. Therefore, this study created a TIICs-related predictive model for patients with KIRC using data from The Cancer Genome Atlas (TCGA). The most important genes associated with CD8 + T lymphocytes were identified using weighted gene co-expression network analysis (WGCNA). Functional categories of important genes were revealed using gene ontology (GO) enrichment and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway analyses. A CD8 + T lymphocyte-related prognostic model with seven important genes was simultaneously created using the least absolute shrinkage and selection operator (LASSO), univariate and multivariate Cox regressions, and the hub genes EOMES, SIRPG, PTPN7, CD3G, APOBEC3G, FASLG, and TIGIT, which were expressed particularly in CD8 + T lymphocytes according to single-cell sequencing data obtained from the Gene Expression Omnibus (GEO). Finally, we used PCR to verify the expression of hub gene in KIRC.This study identified seven genes associated with CD8 + T lymphocytes that may influence risk stratification in patients with KIRC and serve as possible CD8 + T lymphocyte-related biomarkers.
Relationship between IL-6 and IL-10 Inflammatory Cytokines and Severity Criteria in Trauma Victims.
Authors: de Oliveira Rodrigo Gonçalves , Shio Marina Tiemi , Bachi André Luis Lacerda , Ribeiro Ana Paula , Sabbion Rodrigo Olivio , Colombo-Souza Patrícia 
Published: November 2023

Abstract
Background: The severity of the clinical status of polytrauma patients may be associated with an increase in the systemic inflammatory state mediated by cytokines. In fact, it has been suggested that the levels of pro- and anti-inflammatory cytokines can be used as prognostic indicators in trauma patients, since higher levels of IL-6 and lower levels of IL-10 are associated with worse outcomes, according to the trend shown in recent studies. Therefore, the objective of this study was to verify the relationship between the levels of these cytokines and the severity of the trauma.
Methods: Prospective and analytical study carried out with 20 patients over 18 years of age, victims of trauma, who met the criteria for transfusion of blood components according to the Shock Index (SI) and Assessment of Blood Consumption (ABC Score) as a predictor of severity, at the time of admission (T0) and 48 hours after (T1) admission to the emergency room. Blood samples were collected at these two times to assess the serum concentration of IL-6 and IL-10.
Results: Most patients were male (90%), with a mean age of 33.2 years. In total, 18 patients scored on the Shock Index (90%), 2 patients scored on the ABC Score (10%), and 6 patients (30%) received a score on both. Lower serum IL-10 concentrations were observed at T1 than at T0. IL-6 levels showed no differences between times. Significant positive correlations between IL-6 and IL-10 were evidenced at T0 (p=0.0065) and T1 (p=0.0263). There was an association of IL-6 levels with the ABC score and of IL-10 with the SI score.
Conclusion: Although IL-6 serum levels alone did not change, IL-10 levels were reduced 48 hours after patient admission. In addition, the criteria for patient selection showed a significant association with the cytokines IL-6 and IL-10, suggesting that in addition to being predictors of blood transfusion, they could also be used as markers of severity in polytrauma patients.
Efficacy and safety of calcineurin inhibitors (CNIs) for septic patients in ICU: A cohort study from MIMIC database
Authors: Miao ShengHui , Yang Mingkun , Yang Zhouxin , Yan Jing 
Published: November 2023

Abstract
Background
Sepsis is characterized by a dysregulated immune response to infection. Calcineurin inhibitors (CNIs) is a widely used immunosuppressant and has unique properties that may be associated with beneficial outcomes of patients with sepsis by keeping down of an overactive immune response. Our research is designed to investigate whether the use of CNIs exempt septic patients from adverse prognosis and assess whether it might bring about some adverse reactions.
Methods
The Medical Information Mart for Intensive Care IV 2.2 (MIMIC-IV 2.2) database was searched to identify septic patients with and without the use of CNIs. Propensity score matching (PSM) was applied to balance the baseline characteristics between the CNIs group and the non-user group. The primary outcome was 28-day mortality, the relationship between CNIs and patient death was analyzed by Kaplan-Meier method and Cox proportional hazard regression models.
Results
22517 patients with sepsis were extracted from the MIMIC IV database. In the propensity score-matched sample of 874 individuals, lower 28-day mortality risks were observed in the CNIs group compared to the non-users’ group (HR: 0.26; 95%CI: 0.17, 0.41) by univariate cox hazard analysis. In addition, the Kaplan-Meier survival curves indicated a significant superior 28- and 365-day survival rate for CNI users compared to non-users (the log-rank test p-value was 0.001). There was no significant association between the use of CNIs and an increased risk of new onset of infection (p = 0.144).
Conclusion
Calcineurin inhibitors was associated with decreased short- and long-term mortality among septic patients without increased incidence of new onset of infection, hyperkalemia, severe hypertension and AKI, but may generate undesirable reaction such as liver injury and mild hypertension.
Factors Associated with Engraftment Success of Patient-Derived Xenografts of Breast Cancer
Authors: Lee Jongwon , Lee GunHee , Park Hye Seon , Jeong Byung-Kwan , Gong Gyungyub , Jeong Jae Ho , Lee Hee Jin 
Published: November 2023

Abstract
Background
Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of primary breast tumors. Despite their promise, the rate of successful PDX engraftment is various in the literature. This study aimed to identify the key factors associated with successful PDX engraftment of primary breast cancer.
Methods
We integrated clinicopathological data with morphological attributes quantified using a trained artificial intelligence (AI) model to identify the principal factors affecting PDX engraftment.
Results
Multivariate logistic regression analyses demonstrated that several factors, including a high Ki-67 labeling index (Ki-67LI) (p < 0.001), younger age at diagnosis (p = 0.032), post neoadjuvant chemotherapy (NAC) (p = 0.006), higher histologic grade (p = 0.039), larger tumor size (p = 0.029), and AI-assessed higher intratumoral necrosis (p = 0.027) and intratumoral invasive carcinoma (p = 0.040) proportions, were significant factors for successful PDX engraftment (area under the curve [AUC]: 0.905). In the NAC group, a higher Ki-67LI (p < 0.001), lower Miller-Payne grade (p < 0.001), and reduced proportion of intratumoral normal breast glands as assessed by AI (p = 0.06) collectively provided excellent prediction accuracy for successful PDX engraftment (AUC: 0.89).
Conclusions
We found that high Ki-67LI, younger age, post-NAC status, higher histologic grade, larger tumor size, and specific morphological attributes were significant factors for predicting successful PDX engraftment of primary breast cancer.
Pengaruh Kualitas Makanan dan Pelayanan terhadap Loyalitas Pelanggan
Authors: Hati Adistiyani Laras , Sudiarta I Nyoman , Wirawan Putu Eka 
Published: November 2023

Kawasan Loviana merupakan kawasan pariwisata dari Kabupaten Buleleng. Banyak masyarakat yang memulai membuka usaha penyajian makanan seperti bar dan restoran. Setiap manajemen restoran berusaha menawarkan produk makanan dan minuman yang berkualitas kepada pelanggan. Kualitas makanan dan Pelayanan merupakan faktor yang mempengaruhi Loyalitas Pelanggan. Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh variabel Kualitas Makanan dan Pelayanan terhadap Loyalitas Pelanggan . Penelitian ini dilakukan di Heliconia Restaurant The Lovina Bali, yaitu pada bulan Februari sampai dengan April 2021. Metode analisis data yang digunakan dalam penelitian ini adalah regresi linear berganda, dengan penyebaran kuesioner kepada 40 pengujung sebagai sampel, dan teknik pengambilan sampel yang digunakan ialah teknik kuota sampling. Pengujian hipotesis penelitian menggunakan SPSS 25.0. Hasil penelitian ini menunjukkan Varibel Kualitas Makanan dan Pelayanan bersama-sama berpengaruh secara signifikan terhadap Loyalitas Pelanggan yang dapatdilihat dari Uji Determinasi pada Model Summary dengan kontribusi yang di berikansebesar 71,70% dan sisanya 28,30% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini. Berdasarkan hasil analisis tersebut disarankan agar manajemen lebih memperhatikan Kualitas Makanan dan Pelayanan

Loviana area is a tourism area of Buleleng Regency. Many people are starting to open food serving businesses such as bars and restaurants. Every restaurant management strives to offer quality food and beverage products to customers. Food quality and service are factors that affect customer loyalty. The purpose of this study was to determine how much influence the variables of Food Quality and Service on Customer Loyalty had. This research was conducted at Heliconia Restaurant The Lovina Bali, from February to April 2021. The data analysis method used in this study was multiple linear regression, with questionnaires distributed to 40 visitors as samples, and the sampling technique used was the quota technique. sampling. Testing the research hypothesis using SPSS 25.0. The results of this study indicate that Food and Service Quality Variables together have a significant effect on Customer Loyalty which can be seen from theDetermination Test on the Summary Model with the contribution given by 71.70% and the remaining 28.30% influenced by other variables not examined in this study. Based on the results of the analysis, it is recommended that management pay more attention to the quality of food and service
Letters To the Editor
Authors: Rubagumya G. William , Cupples Colleen L. , Campfens Hubert , Roberts John 
Published: November 2023

Please allow me to introduce myself to you: my name is G. William Rubagumya, an attorney in the state of Texas in the USA. I am originally from the country of Rwanda via the refugee camps of Uganda and I have been in the USA for the last 7 years. As you may have guessed, my concern is with the refugees that I left behind both in Ugan- da and other surrounding countries. Myself and other Rwandans in this country have formed a nonprofit organization, The Tutsi Relief Founda- tion Inc., whose main purpose is to aid in any way possible, but with primary emphasis on education and relocation of those who are able to adapt to the changed environment.
Children’s health-related experiences in India: A scoping review
Authors: Wang Yi Wen , Behan Justine , Jeong Sunny , Singh Arora Ramandeep , Carnevale Franco , Tsimicalis Argerie 
Published: November 2023

Background & Objectives: The perspectives of children have becoming increasingly emphasized in healthcare research and practice in order to facilitate children’s inclusion, participation, and decision-making in matters related to their health. In India, however, little is known about children’s views regarding their health despite the various health challenges and ethical concerns they may face, such as poverty, malnutrition, and gender inequalities. The aim of this scoping review is to explore children’s health-related experiences from their own perspectives in India from 2000 to 2020.

Methods: Five online databases were searched. Three independent reviewers screened articles for inclusion. Included texts were analyzed using thematic synthesis, which involved extracting and descriptively coding data, categorizing/grouping codes by similar topics, and comparing and contrasting topics to generate descriptive themes. The scoping review was reported using the PRISMA-ScR checklist.

Results: Fifty-two articles were included, and five descriptive themes were identified. The articles typically overlapped in themes, which related to children’s health-related experiences (n=38), emotions (n=19), and knowledge (n=15); the impact of illness on children’s lives (n=41); and children’s ability to communicate their needs (n=12).

Interpretation & Conclusions: We identified the need to tailor research designs to better elicit children’s perspectives and provide comprehensive health education for children and families in India. This scoping review helped to highlight gaps in healthcare policy, practice, and research, providing a starting point for more focused investigation into children’s health-related experiences in India.
Possibilities of modern remote technologies in neurorehabilitation
Authors: Yastrebtseva I. P. , Sokolova A. A. 
Published: November 2023

The purpose — is to study the available scientific data on the effectiveness of the application of remote rehabilitation technologies in patients with cerebral pathology at the present stage.Material and methods. The search for relevant publications was carried out using the databases Cochrane Library, eLIBRARY.RU, PubMed, Google academy, MedLine, EBSCO, Scopus, Web of science, PEDro, CINAHL, Eric, Springer/nature, Elsevier. The review included 48 papers (systematic reviews, meta-analyses, randomized controlled trials) concerning the use of remote rehabilitation methods in patients with cerebral pathology.Results. Telerehabilitation has been shown to be an emerging healthcare field and the COVID-19 pandemic has accelerated this development. The use of new technologies in the rehabilitation of patients with impaired motor and cognitive functions will improve the quality of care provided for medical rehabilitation, ensuring the continuity and succession of ongoing activities. The use of remote rehabilitation is comparable or even superior in clinical results to an alternative to home training, and the controlled format helps to increase the motivation of patients and improve efficiency. Limitations and obstacles to the implementation of specific technologies are given, ways to overcome them are shown.
PENGARUH KONSENTRASI NAOH PADA SINTESIS MOLECULAR SIEVE BERBAHAN DASAR PIROPILIT TERHADAP RASIO AL/SI, STRUKTUR KRISTAL, DAN POROSITAS
Authors: Riris Idiawati  
Published: November 2023

Molecular sieve (MS) atau dikenal dengan saringan molekul merupakan salah satu produk yang menjadi perhatian para peneliti saat ini karena memiliki kemampuan menyaring gas atau cairan dengan lebih selektif. Molecular sieve terdiri dari dua kelompok besar yaitu molecular sieve alam dan molecular sieve sintesis. Molecular sieve sintesis biasanya diolah dari batuan zeolit atau batuan kaolin karena mengandung unsur silika dan alumina yang tinggi. Piropilit mempunyai kemiripan dengan zeolit ataupun kaolin dimana kandungan alumina dan silika cukup tinggi, sehingga batuan piropilit memiliki potensi untuk dijadikan bahan dasar pembuatan molecular sieve. Pada penelitian ini batuan piropilit diambil dari daerah Sumbermanjing, Malang Selatan. Sintsis MS dilakukan dengan metode leaching NaOH. Hasil yang diperoleh dari uji XRF untuk rasio Al/Si pada MS10, MS15, dan MS20 berturut-turut adalah sebesar 2,4, 2,2, dan 2,3. Hasil XRD menunjukkan terbentuknya 3 fasa pada sintesis MS10 dan MS15 yaitu fasa sodalite dengan sistem kristal kubik, fasa quartz dengan sistem kristal hexagonal, dan fasa diaspore dengan sistem kristal orthorhombik, sedangkan pada MS20 terbentuk fasa murni yaitu fasa sodalite. Ukuran pori hasil uji BET yang dihasilkan pada MS10, MS15, dan MS20 berturut-turut adalah sebesar 30Å (mesopori), 542 Å (makropori), dan 550 Å (makropori), sedangkan untuk surface area yang dihasilkan adalah 0,350 m2/g, 2,869 m2/g, dan 1,176 m2/g. Keberadaan gugus Si-O-Si bending, Si-O-Al, Si-O, Si-O normal to the plane stretching, Inner Surface Al-OH deformation, Si-O-Si siloxine, H-O-H, -OH, C-H stretching, H-O-H bending water ditentukan menggunakan karakterisasi FTIR.