bluuebunny/crossref_metadata_2025_split huggingface dataset:
His bundle pacing in nodal versus infranodal atrioventricular block: a mid-term follow-up study
Authors: Pestrea Catalin , Cicala Ecaterina , Gherghina Alexandra , Ortan Florin , Pop Dana 
Published: December 2023

IntroductionThis study evaluated the feasibility of His bundle pacing (HBP) in consecutive, unselected patients with advanced atrioventricular block (AVB) over a medium-term follow-up period, comparing procedural characteristics between nodal and infranodal sites of the conduction block.Materials and methodsSeventy-five consecutive patients with second-degree or third-degree AVB in which HBP was attempted were prospectively included in this study. The clinical and procedural-related characteristics of the patients were recorded at baseline and over a mid-term follow-up.Results72% of the patients had normal QRS duration at baseline. Intracardiac electrograms revealed nodal AVB in 46 patients (61.3%). The permanent HBP procedural success was significantly higher in nodal AVB (84.8%) vs infranodal AVB (31%). There was no statistical difference between paced QRS duration, impedance, pacing and sensing thresholds and fluoroscopy time in the two groups. Infranodal block, baseline QRS duration, left bundle branch block morphology and ejection fraction were significantly associated with HBP procedural failure. The patients were followed for a period of 627.71±160.93 days. There were no significant differences in parameters at follow-up. An increase of >1 V in the His bundle (HB) capture threshold was encountered in one patient with infranodal AVB (11.1 %) and in four patients with nodal AVB (10.25%).ConclusionPermanent HBP is a feasible pacing technique in nodal AVB with a high success rate and stable thresholds in the medium term. Most infranodal blocks are located within the HB, so there is still the possibility to capture the conduction system, although with lower success rates.
Conditions for anti-Unruh effect
Authors: Wu Dawei , Yang Ji-chong , Shi Yu 
Published: December 2023

AbstractConditions for anti-Unruh effect in (1+1)-dimensional spacetime are obtained. For detectors with Gaussian switching functions, the analytical results are similar to previous ones, indicating that anti-Unruh effect occurs when the energy gap matches the characteristic time scale. However, this conclusion does not hold for detectors with square wave switching functions, in which case the condition turns out to depend on both the energy gap and the characteristic time scale in some nontrivial way. We also show analytically that there is no anti-Unruh effect for detectors with Gaussian switching functions in (3+1)-dimensional spacetime.
As interoperabilidades no processo da documentação e comunicação do patrimônio cultural
Authors: Vizioli Simone Helena Tanoue , Ippolito Alfonso , Martins Gisele , Pazeti Gabriel , Ferreira Giovana Alves , Lima Eduardo Galbes Breda de 
Published: December 2023

O presente artigo coloca em discussão o complexo processo de documentação do patrimônio cultural, desde a concepção do projeto de mapeamento 3D, passando pela aquisição maciça de dados, por escaneamento a laser ou fotogrametria, análise e gestão do data base, elaboração de desenhos científicos e modelos Mesh e HBIM, até a saída/ comunicação das informações, procurando alcançar os objetivos pré-estabelecidos (educação patrimonial, manutenção, conservação e restauro do patrimônio cultural, entre outros). Neste processo, as interfaces, que aqui serão denominadas de interoperabilidades, são ainda hoje, um desafio para os atores do processo, sejam eles os produtores ou receptores da informação. Para tanto, este texto estrutura-se a partir das cinco interoperabilidades presentes no workflow do processo: a interoperabilidade semântica e internacional, a organizacional, a intercomunitária, a técnica e a humana. A pesquisa foi dividida em três momentos: a) revisão bibliográfica; b) experimentação e c) análise e discussão dos resultados. Especificamente quanto à interoperabilidade técnica, isto é, a interface entre os diferentes softwares e entre diferentes meios de representação, a pesquisa se baseou na metodologia de investigação por Design Science Research (DSR), a partir da identificação de uma problemática, aplicação de uma hipótese de otimização da interface entre os modelos mesh e o modelo HBIM, avaliação e análise da mesma, conclusão e aprendizagem com o processo realizado. O estudo que serviu de suporte para discutir as diferentes interoperabilidades no processo da documentação patrimonial, foi o Centro de Divulgação Científica e Cultural da Universidade de São Paulo, em São Carlos - SP.
Quelques jalons dans la préhistoire des sensations internes
Authors: Azouvi François 
Published: December 2023

In this article I have tried to analize the constitution of the notion of internai sensibility, before Reil’s and Cabanis’s works.
Amongst the questions raised by this notion, I mainly discuss the question of the unity or diversity of internai sensations, and the question of their unconsciousness.
As it appears, the notion is worked out in an anticartesian perspective, both in philosophy and physiology.
Mort apparente et procédés de « ressuscitation » dans la littérature médicale du XVIIIe siècle (Bruhier, Winslow, Ménuret de Chambaud, Louis, Réaumur)
Authors: Vecchi Paola 
Published: December 2023

The idea that death is a duration, a reversible, often only apparent process was at the basis of the taphophobia which the Illuminists suffered. This same idea however, opened enormous possibilities for physicians.
By overcoming their different views regarding the doctrines of vitalism and mechanicalism, infact they took on an active role in front of agony and death.
On the other hand, the epistemological pyrrhonism of that period together with this conception of death as a « mixed-state » characterized by indecipherable « signs », favour the medical aim of dominating death and developing techniques of reanimation.
To the failures of diagnostic medicine, the medical profession opposed not only a fairytale compensatory-homeopathic remedy (curing death and illness with apparent death), but also practical researches and techniques along with experimental and therapeutic activism.
La musique comme thérapie des maladies de nerfs à travers des ouvrages de vulgarisation et des traités médicaux de la seconde moitié du XVIIIe siècle
Authors: Imbroscio Carmelina 
Published: December 2023

In the 18th century, authors investigating the effect of music on the human body and soul were many. Apart from specialized studies, allusions to this topic are constantly to be found in works on the theory or the history music, or in medical treatises of a general nature.
It is indeed in the context of a new vision of the whole man, restored after a dualist tradition had long held sway, that — it is argued — this appeal to music as a cure for all ills of mind and body is to be understood.
Polygamy in Timor-Leste
Authors: Kammen Douglas , Tian Yingguihang 
Published: December 2023

Abstract
Demographic studies of polygamy have focused overwhelmingly on the so-called ‘polygamy belt’ in Africa and the Muslim world, and temporally on the past five decades, for which demographic and health surveys are available. Despite a wealth of anecdotal historical evidence, Southeast Asia has been overlooked in the study of polygamy. Drawing on unusually detailed colonial statistics on the collection of a polygamy tax introduced in 1923 and colonial and post-colonial census data, we reconstruct the prevalence of polygamy in Timor-Leste from the late nineteenth century until 2022. In contrast to findings in Africa that emphasize declining rates of polygamy, we find that polygamy has fluctuated across time, likely increasing between the late nineteenth century and the early 1930s, declining modestly during the final decades of colonial rule and the Indonesian occupation, and then rebounding since independence in 2002. We highlight monetization as a key factor explaining both temporal and geographic variation in the practice of polygamy.
Memorabilia of Colonial Violence and Death
Authors: Hermkens Anna-Karina , Venbrux Eric 
Published: December 2023

Abstract
Nineteenth-century, private collections of ethnographic artefacts have a bad reputation in anthropology. Appearing to comprise ‘a haphazard assemblage of junk’ (Gathercole 1978:276), anthropologists and others interested in ethnographic objects and collecting have ignored private collections for some time. While Jean Louis Henri Beijens’s collection resembles at first glance a haphazard assemblage not worthy of attention, a closer inspection reveals its historical and contemporary significance. In this article, we offer a glimpse into Beijens’s private military collection, which contains artefacts originating from the Dutch colonies in both the East and West, as well as from Belgian Congo. Highlighting the colonial self-fashioning that occurred while he was assembling his ‘haphazard’ collection, we elucidate the colonial dispossession and violence that is at the heart of Beijens’s and other private and public collections. In doing so, this article attempts to address the enduring legacies and responsibilities of colonial collecting and collections.
Spatial distribution of PM2.5 concentration around high-rise residential buildings during peak traffic hours in autumn and winter seasons
Authors: He Sining , Yang Lina , Liu Jiying , Jareemit Daranee 
Published: December 2023

This research aimed to investigate the spatial distribution of PM2.5 in residential areas near major urban roads during the autumn and winter seasons. A traffic pollution distribution model was developed using ENVI-met software to predict the distribution of pollution in and around the residential area. The experimental results indicated that during peak hours, the concentration of PM2.5 inside the residential area exceeded 140 μg/m3. The simulations indicated a horizontal diffusion range of traffic pollution up to 300 m, with the most significant effects observed within a radius of 20 m where the pollutant concentration decreased from 131.6 μg/m3 to 93.5 μg/m3. The vertical diffusion of traffic pollution extended to approximately 100 m, with the highest impact observed within a distance of 22.5 m (7 floors). Furthermore, pollution diffused up to a height of 47.5 m near major urban roads, resulting in a decrease in the concentration of PM2.5 from 140 μg/m3 to 70 μg/m3. Quantitative comparisons showed that street pollution was higher in autumn than in winter, whereas pollution outside buildings near the street was higher in winter compared to autumn. Simultaneously, the impact of pollutants on human health was evaluated using the decrease in life expectancy (DLE) index. The results revealed a DLE of 13.16 years in areas with the highest pollution levels, while most residential areas had a DLE ranging between 3.2 and 3.88 years. These findings are significant in terms of raising awareness and providing valuable references for the development and planning of urban health initiatives.
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
Authors: Qiu Dong , Ge Zhaoli , Mei Yanliang , Wang Wei , Xiong Zhonghua , Li Xiaoshuang , Yuan Ziyu , Zhang Peng , Zhang Mantian , Liu Xin , Zhang Yaqing , Yu Xueying , Tang Hefei , Wang Yonggang 
Published: December 2023

Abstract
Background
The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we aim to assess the cortical functional network topological characteristics of NDPH using non-invasive neural signal recordings.

Methods
Resting-state magnetoencephalography (MEG) was used to measure power fluctuations in neuronal oscillations from distributed cortical parcels in 35 patients with NDPH and 40 healthy controls (HCs). Their structural data were collected by 3T MRI. Functional connectivity (FC) of neural networks from 1 to 80 Hz frequency ranges was analyzed with topographic patterns and calculated network topological parameters with graph theory.

Results
In the delta (1–4 Hz) and beta (13–30 Hz) bands, the lateral occipital cortex and superior frontal gyrus FC were increased in NDPH groups compared to HCs. Graph theory analysis revealed that the NDPH had significantly increased global efficiency in the delta band and decreased nodal clustering coefficient (left medial orbitofrontal cortex) in the theta (4–8 Hz) band. The clinical characteristics had a significant correlation with network topological parameters. Age at onset of patients showed a positive correlation with global efficiency in the delta band. The degree of depression of patients showed a negative correlation with the nodal clustering coefficient (left medial orbitofrontal cortex) in the theta band.

Conclusion
The FC and topology of NDPH in brain networks may be altered, potentially leading to cortical hyperexcitability. Moreover, medial orbitofrontal cortex is involved in the pathophysiological mechanism of depression in patients with NDPH. Increased FC observed in the lateral occipital cortex and superior frontal gyrus during resting-state MEG could serve as one of the imaging characteristics associated with NDPH.
The clinical characteristics and therapeutic outcomes of adult patients with community-acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan
Authors: Lien Chia-Yi , Chien Chun-Chih , Lu Cheng-Hsien , Chang Wen-Neng 
Published: December 2023

Abstract
Purpose
To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course.

Materials and methods
The clinical features and therapeutic outcomes of 127 adult CASBM patients were analyzed. The patients were divided into two groups as those with and without a fulminant clinical course. Fulminant clinical course was defined as meningitis presenting initially with marked consciousness disturbance (Glasgow Coma Scale score < 8) or a rapid deterioration in consciousness level within 48 h of hospitalization.

Results
Among the 127 enrolled patients, 69 had a fulminant clinical course (47 men and 22 women) and 58 did not. The patients with a fulminant clinical course had a significantly higher incidence of end-stage renal disease (ESRD), severe clinical manifestations and higher mortality rate, and the survivors had significantly worse therapeutic outcomes. Klebsiella (K.) pneumoniae (50 strains) was the most important pathogen for the development of a fulminant clinical course, and all strains were susceptible to ceftriaxone and ceftazidime. With treatment, 50.7% (35/69) of the patients with a fulminant clinical course died, and the presence of K. pneumoniae infection was significant prognostic factor.

Conclusions
The presence of ESRD, initial presentation of altered consciousness, septic shock, seizures and CSF total protein level and K. pneumoniae infection were significantly associated with a fulminant clinical course of adult CASBM, and patients with this specific infectious syndrome had high mortality and morbidity rates. The presence of K. pneumoniae infection is a significant prognostic factor.
Oxytocin infusion for maintenance of uterine tone under prophylactic phenylephrine infusion for prevention of post-spinal hypotension in cesarean delivery: a prospective randomised double-blinded dose-finding study
Authors: Jin Xiao-Qin , Shen Yao-Hua , Fu Fan , Yu Juan , Xiao Fei , Huang Xiao-Dong 
Published: December 2023

Abstract
Background
Prior studies have shown that, when administered as an intravenous bolus to prevent uterine atony, prophylactic phenylephrine infusion increased the dose requirement of oxytocin and second-line uterotonics. For the prevention of uterine atony, oxytocin should be delivered by continuous infusion. Here, we aimed to determine the ED50 and ED90 parameters (the effective doses for 50 and 90% patients without uterine atony) of oxytocin for co-infusion with prophylactic phenylephrine during cesarean delivery.

Methods
In this prospective randomized double-blinded dose-finding study, one hundred patients were divided into four groups to receive 2.5, 5.0, 7.5, or 10 IU/h oxytocin infusion, after the umbilical cord was clamped during the study period. The uterine tone was evaluated and defined as either adequate or inadequate. Probit regression analysis was applied to calculate the ED50 and ED90 of oxytocin infusion. Uterine tone, the percentage of patients who needed additional oxytocin bolus, second-line uterotonics, side effects, estimated blood loss, and neonatal outcomes were monitored.

Results
The estimated ED50 and ED90 values of the oxytocin infusion doses for the prevention of uterine atony were 1.9 IU/h (95% CI -4.6-3.8) IU/h and 9.3 IU/h (95% CI 7.3–16.2) IU/h, respectively. Across groups, there was a significant linear trend between the infusion dose and the percentage of patients who required additional oxytocin (p-value = 0.002). No differences were observed in the incidence of side effects and neonatal outcomes.

Conclusion
Under the conditions of this study, the ED90 of oxytocin infusion for the prevention of uterine atony was 9.3 IU/h, which is higher than the current recommendation. This finding is helpful for clinical practice, because of the routine use of phenylephrine in cesarean delivery. Further studies are needed to determine the appropriate initial bolus of oxytocin after neonatal delivery.

Trial registration
The study was registered on the Chinese Clinical Trial Register (register no. ChiCTR2200059556).
Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors
Authors: Wang Jiani , Gui Lin , Mu Yuxin , Wang Jiayu , Chi Yihebali , Liu Zhenteng , Li Qing , Xu Binghe 
Published: December 2023

Abstract
Background
The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate the safety, pharmacokinetics (PK), and pilot efficacy of LXI-15029, an mTORC1/2 dual inhibitor, in Chinese patients with advanced malignant solid tumors.

Methods
Eligible patients with advanced, unresectable malignant solid tumors after failure of routine therapy or with no standard treatment were enrolled to receive ascending doses (10, 20, 40, 60, 80, 110, and 150 mg) of oral LXI-15029 twice daily (BID) (3 + 3 dose-escalation pattern) until disease progression or intolerable adverse events (AEs). The primary endpoints were safety and tolerability.

Results
Between June 2017 and July 2021, a total of 24 patients were enrolled. LXI-15029 was well tolerated at all doses. Only one dose-limiting toxicity (grade 3 increased alanine aminotransferase) occurred in the 150 mg group, and the maximum tolerated dose was 110 mg BID. The most common treatment-related AEs were leukocytopenia (41.7%), increased alanine aminotransferase (20.8%), increased aspartate aminotransferase (20.8%), prolonged electrocardiogram QT interval (20.8%), and hypertriglyceridemia (20.8%). No other serious treatment-related AEs were reported. LXI-15029 was absorbed rapidly after oral administration. The increases in the peak concentration and the area under the curve were greater than dose proportionality over the dose range. Eight patients had stable disease. The disease control rate was 40.0% (8/20; 95% CI 21.7–60.6). In evaluable patients, the median progression-free survival was 29 days (range 29–141).

Conclusions
LXI-15029 demonstrated reasonable safety and tolerability profiles and encouraging preliminary antitumor activity in Chinese patients with advanced malignant solid tumors, which warranted further validation in phase II trials.

Trial registration
NCT03125746(24/04/2017),http://ClinicalTrials.gov/show/NCT03125746
Does body mass index distinguish motor proficiency, social and emotional maturity among adolescent girls?
Authors: Badicu Georgian , Zamani Sani Seyed Hojjat , Fathirezaie Zahra , Esmaeili Mohaddese , Bassan Júlio Cesar , González-Fernández Francisco Tomás , Yagin Fatma Hilal , Alghannam Abdullah F. , Cataldi Stefania , Fischetti Francesco , Greco Gianpiero 
Published: December 2023

Abstract
Background
The objective of this study was to investigate whether different body mass index (BMI) groups could serve as a distinguishing factor for assessing motor proficiency and social and emotional maturity in adolescent girls.

Methods
140 girls ranging from 12 to 14.5 years old were selected from the schools of Tabriz city, Iran. After their height and weight were measured to calculate body mass index, they completed the following questionnaires: Bruininks-Oseretsky Test of motor proficiency, Second Edition,Vineland Social Maturity Scale, and Emotional Maturity scale.

Results
normal-weight girls had a meaningful advantage against overweight and underweight participants in the gross motor factor of motor proficiency (p = 0.004), but there wasn’t a meaningful difference in the fine motor p = 0.196) and coordination factors (p = 0.417). Also, social maturity showed an advantage of normal and underweight adolescent girls in the self-help dressing factor (p = 0.018), while the locomotion skills (p = 0.010) factor revealed a better performance of normal weight and overweight groups over underweight adolescents. No significant differences were observed in the emotional maturity subscales (p = 0.63) between the groups.

Conclusions
The present study demonstrates that BMI has a direct influence on adolescents’ gross motor proficiency and social maturity.
Development of a risk prediction model to predict the risk of hospitalization due to exacerbated asthma among adult asthma patients in a lower middle-income country
Authors: Punyadasa Dhanusha Harshinie , Kumarapeli Vindya , Senaratne Wijith 
Published: December 2023

Abstract
Background
Asthma patients experience higher rates of hospitalizations due to exacerbations leaving a considerable clinical and economic burden on the healthcare system. The use of a simple, risk prediction tool offers a low-cost mechanism to identify these high-risk asthma patients for specialized care. The study aimed to develop and validate a risk prediction model to identify high-risk asthma patients for hospitalization due to exacerbations.

Methods
Hospital-based, case-control study was carried out among 466 asthma patients aged ≥ 20 years recruited from four tertiary care hospitals in a district of Sri Lanka to identify risk factors for asthma-related hospitalizations. Patients (n = 116) hospitalized due to an exacerbation with respiratory rate > 30/min, pulse rate > 120 bpm, O2 saturation (on air) < 90% on admission, selected consecutively from medical wards; controls (n = 350;1:3 ratio) randomly selected from asthma/medical clinics. Data was collected via a pre-tested Interviewer-Administered Questionnaire (IAQ). Logistic Regression (LR) analyses were performed to develop the model with consensus from an expert panel. A second case-control study was carried out to assess the criterion validity of the new model recruiting 158 cases and 101 controls from the same hospitals. Data was collected using an IAQ based on the newly developed risk prediction model.

Results
The developed model consisted of ten predictors with an Area Under the Curve (AUC) of 0.83 (95% CI: 0.78 to 0.88, P < 0.001), sensitivity 69.0%, specificity 86.1%, positive predictive value (PPV) 88.6%, negative predictive value (NPV) 63.9%. Positive and negative likelihood ratios were 4.9 and 0.3, respectively.

Conclusions
The newly developed model was proven valid to identify adult asthma patients who are at risk of hospitalization due to exacerbations. It is recommended as a simple, low-cost tool for identifying and prioritizing high-risk asthma patients for specialized care.