bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI-based radiomic nomogram for predicting disease-free survival in patients with locally advanced rectal cancer
Authors: Wen Lu , Liu Jun , Hu Pingsheng , Bi Feng , Liu Siye , Jian Lian , Zhou Jumei , Nie Shaolin , Cao Fang , Lu Qiang , Yu Xiaoping , Liu Ke 
Published: January 2024

Abstract

Individual prognosis assessment is of paramount importance for treatment decision-making and active surveillance in cancer patients. We aimed to propose a radiomic model based on pre- and post-therapy MRI features for predicting disease-free survival (DFS) in locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy (nCRT) and subsequent surgical resection. This retrospective study included a total of 126 LARC patients, which were randomly assigned to a training set (n=84) and a validation set (n=42). All patients underwent pre- and post-nCRT MRI scans. Radiomic features were extracted from higher resolution T2 -weighted images. Pearson correlation analysis and ANOVA or Relief were utilized for identifying radiomic features associated with DFS. Pre-treatment, post-treatment, and delta radscores were constructed by machine learning algorithms. An individualized nomogram was developed based on significant radscores and clinical variables using multivariate Cox regression analysis. Predictive performance was evaluated by the C-index, calibration curve, and decision curve analysis. The results demonstrated that in the validation set, the clinical model including pre-surgery Carcinoembryonic Antigen (CEA), chemotherapy after radiotherapy, and pathological stage yielded a C-index of 0.755 (95% confidence interval [CI]: 0.630-0.880). While the optimal pre-, post-, and delta-radscores achieved C-indices of 0.724 (95%CI: 0.585-0.863), 0.701 (95%CI: 0.544-0.858), and 0.625 (95%CI: 0.439-0.811), respectively. The nomogram integrating pre-surgery CEA, pathological stage, alongside pre- and post-nCRT radscore, obtained the highest C-index of 0.833 (95%CI: 0.694-0.972). The calibration curve and decision curves exhibited good calibration and clinical usefulness of the nomogram. Furthermore, the nomogram categorized patients into high- and low-risk groups exhibiting distinct DFS (both P<0.0001). In summary, the nomogram incorporating pre- and post-therapy radscores and clinical factors could predict DFS in patients with LARC, which warrants further external validations.
Experimental study on joint sensing and early warning method of landslide disaster based on NPR-OFST
Authors: Tao Zhigang , feng yuxiang , Zhang Xiaoyu , yu zhehan 
Published: January 2024

Abstract

In order to explore more effective methods of landslide disaster monitoring and controlling, NPR anchor cable and optical fiber grating strain sensor are physically combined to form a slope reinforcement-monitoring integration system, with PVC pipe an intermediary. Physical model test is carried out according to timely warning of landslide disasters of the Newtonian force monitoring system. At the same time, the optical fiber sensing technology has the condition of continuous perception of time and space. The feasibility of monitoring the whole life cycle of slope instability and positioning the potential sliding surface is discussed. Through the analysis of the test results, it is concluded that the fiber grating strain sensor can effectively monitor the deep displacement of the slope. PVC pipe and the soil have deformation coordination, which is able to effectively reinforce the slope body together with the combined anchor cable sensing device, and can continuously sense the potential sliding surface in the whole life cycle of the slope. By comparing the results of Newton force monitoring curve with the fiber grating strain monitoring, the mechanical law of “Newton force sudden drops, immediately catastrophe happens” is further verified. Finally, it is concluded that the combined sensing and early warning method of optical fiber sensing technology and Newton force monitoring can realize comprehensive monitoring and control of landslide disasters. This method realizes the further optimization of Newton force monitoring system.
Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
Authors: Lawson Catherine , Kryshtafovych Andriy , Pintilie Grigore , Burley Stephen , Cerny Jiri , Chen Vincent , Emsley Paul , Gobbi Alberto , Joachimiak Andrzej , Noreng Sigrid , Prisant Michael , Read Randy , Richardson Jane , Rohou Alexis , Schneider Bohdan , Sellers Benjamin , Chao Chenghua , Sourial Elizabeth , Williams Chris , Williams Christopher , Yang Ying , Abbaraju Venkat , Afonine Pavel V. , Baker Matthew , Bond Paul , Blundell Tom , Burnley Tom , Campbell Arthur , Cao Renzhi , Cheng Jianlin , Chojnowski Grzegorz , Cowtan Kevin , Dimaio Frank , Esmaeeli Reza , Giri Nabin , Grubmüller Helmut , Hoh Soon Wen , Hou Jie , Hryc Corey , Hunte Carola , Igaev Maxim , Joseph Agnel , Kao Wei-Chun , Kihara Daisuke , Kumar Dilip , Lang Lijun , Lin Sean , Subramaniya Sai Raghavendra Maddhuri Venkata , Mittal Sumit , Mondal Arup , Moriarty Nigel , Muenks Andrew , Murshudov Garib , Nicholls Robert , Olek Mateusz , Palmer Colin , Perez Alberto , Pohjolainen Emmi , Pothula Karunakar , Rowley Christopher , Sarkar Daipayan , Schäfer Luisa , Schlicksup Christopher , Schroeder Gunnar , Shekhar Mrinal , Si Dong , Singharoy Abhishek , Sobolev Oleg , Terashi Genki , Vaiana Andrea , Vedithi Sundeep , Verburgt Jacob , Wang Xiao , Warshamanage Rangana , Winn Martyn , Weyand Simone , Yamashita Keitaro , Zhao Minglei , Schmid Michael , Berman Helen , Chiu Wah 
Published: January 2024

Abstract

The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic (1.9-2.5 Å) resolution. Three published maps were selected as targets: E. coli beta-galactosidase with inhibitor, SARS-CoV-2 RNA-dependent RNA polymerase with covalently bound nucleotide analog, and SARS-CoV-2 ion channel ORF3a with bound lipid. Sixty-one models were submitted from 17 independent research groups, each with supporting workflow details. We found that (1) the quality of submitted ligand models and surrounding atoms varied, as judged by visual inspection and quantification of local map quality, model-to-map fit, geometry, energetics, and contact scores, and (2) a composite rather than a single score was needed to assess macromolecule+ligand model quality. These observations lead us to recommend best practices for assessing cryo-EM structures of liganded macromolecules reported at near-atomic resolution.
Comparative efficacy of UBE-LIF and MIS-TLIF in Lumbar Spondylolisthesis
Authors: Li Kuankuan , Ma Haijun , Yang Hejun , Tang Zhongxin , Zhang Haoping , Liu Xuesen , Xu Xiaoxiao , Zhou Honggang , Shen Mingkui 
Published: January 2024

Abstract
Objective
To evaluate the efficacy of unilateral biportal endoscopy lumbar interbody fusion (UBE-LIF) in the treatment of lumbar spondylolisthesis and instability.
Methods
A retrospective analysis was performed on 64 single-segment lumbar spondylolisthesis and instability patients between May 2020 and November 2020, 30 of whom underwent UBE-LIF and 34 of whom underwent minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). The operative time, intraoperative blood loss, complications, hospitalization days and the visual analog scale (VAS) and Oswestry disability index (ODI) and the rate of bone fusion were recorded.
Results
All patients were followed up with an average of 26.26 ± 2.15 months. The average operation time and intraoperative blood loss in the UBE-LIF group were less than those in the MIS-TLIF group (P < 0.05). In both groups, VAS score improved from preoperative (7.07 ± 0.83) to postoperative Day 1 (4.4 ± 0.56), ODI improved from preoperative (55.7 ± 2.49) to postoperative Day 1 (37.57 ± 3.01), and in MIS-TLIF group, VAS score improved from preoperative (7.15 ± 1.02) to postoperative Day 1 (4.88 ± 0.98), ODI improved from preoperative (55.94 ± 2.5) to postoperative Day 1 (40.06 ± 3.68), and the postoperative Day 1 VAS score and ODI were significantly improved, with a difference that was statistically significant (P < 0.05). The VAS and ODI, respectively at 3 months and the last follow-up were not significantly different between the two groups. There was no significant difference in bone fusion between the two groups.
Conclusion
UBE-LIF technology is safe and effective for the decompression of lumbar instability and spondylolisthesis. It can achieve the same decompression and fusion effect as MIS-TLIF. It is an effective operation for the treatment of lumbar spondylolisthesis and instability.
A novel noninvasive multi-target electrical stimulation method: simulation and experimental validation
Authors: Zhu Kai , Zhou Xiaoqing , Liu Xu , Ma Ren , Wang Mingpeng , Zhang Shunqi , Yin Tao , Liu Zhipeng 
Published: January 2024

Abstract
The brain is a complex system of structure and function. Brain diseases and brain functional abnormalities often involve multiple functionally connected regions, include the deep brain. Studies have shown that multi-target electrical stimulation is more effective than single-target electrical stimulation. However, non-invasive multi-target electromagnetic stimulation, such as multi-target transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) cannot meet the needs of synchronous multi-target accurate electrical stimulation at the deep brain. In this paper, based on the principle of magneto-acoustic coupling and phased array focusing technology, a novel non-invasive multi-target transcranial magneto-acoustic coupling electrical stimulation (multi-target TMAES) method is proposed. A simulation model and experimental system were established. The simulation and experimental results proved that the proposed multi-target TMAES can non-invasively achieve precise focused electrical stimulation of multiple targets (≥ 2) with a focus area of ​​65 mm2 at the deep brain. The location and intensity of the multi-target electrical stimulation can be flexibly changed by adjusting the system parameters according to the actual need. It will provide a new and promising tool for the treatment of brain diseases and the study of neural circuits and brain functional connectivity.
Conjunctive optimal design of water and power networks
Authors: Shmaya Tomer , Perelman Gal , Ostfeld Avi 
Published: January 2024

Abstract
Water distribution systems (WDS) and power grids (PG) are critical infrastructure systems that are vital to all human activity. As such, their quality of service is of great importance for economic, environmental, and human welfare reasons. Although traditionally being analyzed separately, the two systems are interconnected and can mutually affect one another. WDSs are among the largest energy consumers in PGs, with 7–8% of the world’s total generated energy used for drinking water production and distribution (Sharif et al. 2019). At the same time, WDS storage facilities allow regulating power loads by load shifting operation policies and even storing energy by using turbines. Therefore, decisions made as part of operating one system influence the operation policy of the other. In order to utilize the potential benefits that the two systems can produce for each other, their design and operation should be analyzed conjunctively. In this paper, a conjunctive optimal design approach for water and power networks is presented, with the objective of finding the dimensions of the systems' facilities that will result in minimal overall costs, for both design and operation. The model is formulated and implemented on two example applications using an off-the-shelf nonlinear solver by MATLAB and compared to the optimal design of the independent WDS. A sensitivity analysis is performed to provide validity to the obtained results.
Trends in Incidence and Survival of Childhood Cancers in Khon Kaen, Thailand (2000-2019): A Population-Based Khon Kaen Cancer Registry Study
Authors: Pinsuwan Chanaporn , Santong Chalongpon , Chainansamit Su-on , Komvilaisak Patcharee , Sirikarn Prapassara , Phimha Surachai , Suwannaying Kunanya 
Published: January 2024

Abstract

Background In Thailand, the national health care system and nationwide standard treatment protocols have evolved over time, potentially influencing the trends in the incidence and survival rates of childhood cancers. However, further investigations are required to comprehensively study these trends in Khon Kaen, Thailand. Methods Childhood cancer patients aged 0–14 years (n = 541) who were diagnosed with one of the five most common cancers between 2000 and 2019 from the population-based Khon Kaen Cancer Registry were enrolled. Descriptive statistics were used to analyse the demographic data, which are presented as numbers, percentages, means, and standard deviations. The trends in incidence between 2000 and 2019, including age-standardized incidence rates (ASRs) and annual percent changes (APCs), were analysed using the Joinpoint regression model. Survival analysis was performed for 5-year relative survival rates (RSRs) according to the Pohar Perme estimator and Kaplan–Meier survival curves. Results The ASRs of the overall top 5 childhood cancer groups were 67.96 and 106.12 per million person-years in 2000 and 2019, respectively. Overall, the APC significantly increased by 2.37% each year for both sexes. The overall 5-year RSRs were 60.5% for both sexes, 58.2% for males, and 63.9% for females. The highest 5-year RSR was for germ cell tumours (84.3%), whereas the lowest 5-year RSR was for neuroblastoma (29.1%). Conclusions The incidence and survival rates of childhood cancers in Khon Kaen, Thailand, varied according to age and sex. The trend in incidence and survival increased over time. The implementation of national health policies and adherence to national treatment guidelines have improved cancer diagnosis and treatment outcomes.
The Impact of Therapy Dogs on Anxiety and Emotional Management in the Pediatric Emergency Department
Authors: Lucrezia Samantha , Edgerton Amy , Feygin Yana , Stevenson Michelle 
Published: January 2024

Abstract
Objectives
determine change in emotional management in children 4–12 years after a visit from a therapy dog and certified child life specialist (CCLS) handler, via observed modified CEMS scores (Children’s Emotional Management Scale), and to determine change in perceived anxiety reported by caregivers, via Subjective Unit of Distress (SUD) score.
Methods
Prospective observational study at a large/urban ED within a freestanding children’s hospital from May-July 2021. Children 4–12 years with at least mild anxiety (SUD ≥ 30) eligible. Children ineligible: current infection, transferred, presented for burn care/dog bite, history of neutropenia/oncologic process, triaged ESI category 1/2, patient/caregiver with fear/allergy to dogs, or already had undergone a procedure. Participants received a 10-minute visit with CCLS and therapy dog. Modified CEMS (accounting for mask use) and SUD scores recorded prior and after intervention by research team and caregiver, respectively.
Results
95 patients approached, no families refused participation, 41 enrolled. After the intervention, modified CEMS scores significantly decreased (p < 0.001), as well as parental perceived anxiety via SUD score (p < 0.001). Mean duration of intervention was 9.10 (3.58) minutes; mean ED length of stay was 3.33 (1.50) hours. 95% of caregivers reported strong satisfaction with therapy dog.
Conclusions
An encounter with a therapy dog and CCLS handler significantly improves emotional management and decreases anxiety in pediatric patients in the ED. Caregivers perceive therapy dogs as calming for their child and praised the intervention. These results support future prospective randomized trials involving therapy dogs in managing pediatric distress in the ED.
Relation Between Pregnancy Psychological Status and Prenatal Depression: A Path Analysis
Authors: Talebi Erfaneh , Mohaddesi Hamideh , Rasouli Javad , Kaviani Shaghayegh 
Published: January 2024

Abstract

Background
Pregnancy is the most stressful period of a woman’s life, during which conditions such as neuroticism, depression, and anxiety are highly prevalent. Considering the literature emphasizing the adverse effects of prenatal depression on the mother and foetus, even in later periods such as childhood and adulthood, the present study aims to identify factors related to prenatal depression among women.
Methods
This cross-sectional (descriptive and analytical) study was conducted on 130 pregnant women referring to health centres in Urmia in 2021. The participants were selected using the multi-stage random sampling method. The instruments included a Demographic-Pregnancy Questionnaire, Edinburgh Postnatal Depression Scale (EPDS), Pregnancy Experience Scale (PES), Positive Feeling Questionnaire (PFQ), and Prenatal Distress Questionnaire (PDQ).
Results
The depression rate was obtained at 38% among pregnant women. Prenatal depression was negatively correlated with positive feelings towards the spouse and pregnancy experience. However, it was directly associated with prenatal distress. Moreover, women’s employment status and their husbands’ education could affect prenatal depression.
Conclusion
The results revealed psychological factors such as feelings towards the spouse and pleasant or unpleasant experiences during pregnancy affected women’s mental health. Thus, these factors should be considered when performing interventions to improve depression during pregnancy. Healthcare clinics should be equipped with depression diagnosis tools in routine care programs to screen pregnant mothers, diagnose prenatal depression early, and perform appropriate interventions.
Ethical code:
IR.UMSU.REC.1400.214
Impact of a multi-disciplinary team-based care model for patients living with diabetes on health outcomes: a mixed-methods study
Authors: Jacobs Jacquelyn , Dougherty Alyn , McCarn Banita , Saiyed Nazia , Ignoffo Stacy , Wagener Christina , Miguel Cindy San , Martinez Linda 
Published: January 2024

Abstract

Background
Individuals facing socioeconomic hardship experience higher than average rates of chronic disease, such as diabetes, with less access to evidence-based treatment. One solution to address these inequities is a team-based care (TBC) model, defined as one in which at least two providers work collaboratively with a patient and their caregiver(s) to make healthcare decisions. This paper seeks to examine the implementation of a TBC model within a safety-net healthcare setting and determine the extent to which it can be an effective, patient-centered approach to treating individuals with diabetes.
Methods
Semi-structured interviews were conducted with staff (n = 15) and patients (n = 18). Clinical data were extracted from the electronic medical record of patients (n = 1,599) seen at a safety-net health system in Chicago, Illinois, United States. The mixed methods study was guided by implementation science and participatory research principles. Staff interviews were 60 minutes and covered patient care activities, work flow, perceived patient experience, and facilitators/barriers to care coordination. Patient interviews were 60 minutes and covered satisfaction, attitudes about diabetes management, quality of life, and technology. Patient interviews were co-analyzed by research staff and members of a patient advisory committee. Clinical data were collected at an index visit, two years prior and at one-year follow up (n = 1,599).
Results
Four themes emerged from the interviews: (1) patients perceived the TBC model to be patient centered and of high quality; (2) technology can be an innovative tool, but barriers exist; (3) diabetes management is a complex process; and (4) staff communication enhances care coordination, but misinterpreting roles reduces care coordination. From pre-enrollment to the follow-up period, we found a statistically significant increase in missed visits, decrease in hemoglobin A1c (HbA1c), decrease in body mass index, and decrease in the percent of patients with high blood pressure. We found that each medical visit during the follow-up period was associated with an HbA1c decrease of 0.26 points.
Conclusions
A TBC model is a patient-centered approach to providing care to patients with complex health needs, such as diabetes, patients were satisfied with the care they were receiving, and the model was associated with an improvement in clinical outcomes.
Matrix-based project dataset parsers
Authors: Kosztyán Zsolt Tibor , Novák Gergely Lajos 
Published: January 2024

Abstract

There are several existing project datasets, which involve separate data sources for simulated and real projects, individual and multiprojects, and single- and multimodal attributes. In addition, their file structures are heterogeneous; therefore, scholars can usually use only one dataset to test a proposed scheduling or resource allocation algorithm. Since the internal structures of these projects are also very different, it is difficult to ensure that an algorithm optimized for a given type of project will also perform well on projects with other structures. The parser we propose can read several types of projects: simulated, real, individual, and multiprojects, as well as single- and multimodal attributes. In addition, it can consider the priorities of activities and the flexibility of their dependencies, which is essential for modeling the structural flexibility employed by agile, hybrid, and extreme project management approaches. Thus, researchers can build a large project database for testing and comparing different scheduling and resource allocation algorithms.
Stereoselective Polar Radical Crossover for the Functionalization of Strained-Ring Systems
Authors: Didier Dorian , Trauner Florian , Ghazali Rahma , Rettig Jan , Thiele Christina 
Published: January 2024

Abstract

Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry. However, step-economic methods for their selective functionalization remains scarce. Here we present a one-pot strategy that merges a simple preparation of strained organoboron species with the recently popularized polar radical crossover of borate derivatives to stereoselectively access tri-substituted azetidines, cyclobutanes and five-membered carbo- and heterocycles.
Finite Element Modelling of Ultrasonic Assisted Hot Pressing of Metal Powder
Authors: Abedini Rezvan , Fartashvand Vahid , Abdullah Amir , Alizadeh Yunes 
Published: January 2024

Abstract

Ultrasonication has widely been used in many industries to develop advanced materials, improve materials behaviors, and enhance mechanical strength to name a few. The present investigation aims to accelerate the densification mechanisms during the hot-pressing process of Ti-6Al-4V powder through high power ultrasonication. A computational study has been developed and implemented to simulate the consolidation behavior, which have then been compared with those experimental data to ensure the simulation accuracy. The constitutive equations including thermoplastic and power law creep models, were extracted at each of the aforesaid stages and applied by FORTRAN software, respectively, in the form of UMAT and CREEP subroutines in the simulation. Finally, the simulation results in relative density-time diagrams and density distribution have been compared with the results of experimental tests. The comparison of the simulation and experimental results shows a maximum error of 6.8 and 2.8% in predicting the densification behavior of hot pressing without and with ultrasonication, respectively. The results show the good accuracy of the simulation in predicting final relative density and density distribution with ultrasonic vibrations.