bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing predictive abilities of hazard-based regression models for survival data: a tutorial for prognosis modelling
Authors: Fournier Marguerite , Rubio Francisco Javier , Chartier Loïc , Maringe Camille , Belot Aurélien 
Published: January 2024

Abstract

Predicting the occurrence of an event over time for a newly diagnosed individual is a common aim in medical statistics. For time-to-event outcomes, this prediction is typically based on a regression model. The Cox proportional hazard (PH) model represents one of the most popular regression models for analysing time-to-event data. However, several flexible models that go beyond the assumption of proportionality of hazards have been recently developed. These include flexible hazard-based models using splines or models based on more general hazard structures. In these 2 types of models, non-linear associations and time-varying regression coefficient(s) can be easily included. Assessing the predictive ability of a hazard-based regression model is necessary to validate a predictive model but it might prove difficult for models other than the Cox PH model. We present a tutorial which explains how the predictive ability of hazard-based regression models can be assessed, focusing on the 3 commonly used performance measures. We report (i) the overall prediction ability using prediction error curve and the Brier score, (ii) the discriminative ability using the cumulative/dynamic area under the receiving operator characteristic curve, and (iii) the calibration ability, i.e., the agreement between observed and predicted probabilities, using calibration plots and graphical comparison between predicted and observed survival. We provide an implementation of these methods in R together with an illustrative example using a publicly available data set.
Identification of marophage-related biomarkers in acute myocardial infarction (AMI) by bioinformatic analysis and clinical validation Running title: Macrophage-related biomarkers in AMI
Authors: Xi Xiangwen , Chen Yu , Qian Zhipeng , Xie Xianwei , Tian Jiangtian , Fu Qiang , Gu Xia 
Published: January 2024

Abstract
Background
Although reperfusion therapy is widely performed in patients with acute myocardial infarction (AMI), the residual risk of poor prognosis remains substantial. As important immune cells involved in the body's inflammatory response, macrophages are differentiated from monocytes that have been recruited to tissues, and their polarisation status has a significant impact on the development and prognosis of AMI. There are no recognised macrophage-associated key regulators that play an important role in the development of AMI.
Objective
The study aimed to identify potential biomarkers associated with macrophages for the early recognition and intervention of AMI.
Methods and results
Three datasets which can be obtained publicly (GSE48060, GSE66360, and GSE97320 datasets) from the Gene Expression Omnibus (GEO) database were analysed to identify differentially expressed genes (DEGs) using peripheral blood tissue samples from 83 AMI patients and 74 normal individuals. Subsequent WGCNA analysis was performed and 387 genes with the most significant correlations with macrophages were identified. Then, intersecting 192 DEGs with 387 genes from WGCNA, a total of 151 overlapping genes were found. Protein-protein interaction (PPI) network analysis were performed to identify the hub genes. Further we recruited 44 individuals and colleted blood samples to validate the stability and reliability of the predicted hub tragets toll-like receptor 2 (TLR2), toll-like receptor 2 (TLR4), toll-like receptor 8 (TLR8), matrix metalloproteinase 9 (MMP9) and tyrosine kinase binding protein (TYROBP) using qRT-PCR assay. As a result, TLR2, TLR4, TLR8, MMP9 and TYROBP were identified as the marophage-related biomarkers in AMI.
Conclusions
The macrophage-related genes TLR2, TLR4, TLR8, MMP9 and TYROBP may enable timely detection of AMI, leading to prompt intervention and better prognosis.
Optimizing Multi-model Ensemble of CMIP6 GCMs for Climate Simulation: A Case Study over Bangladesh
Authors: Talukder Afifa , Shaid Shamsuddin , Hwang Syewoon , Alam Edris , Kamruzzaman Mohammad 
Published: January 2024

Abstract
This study aims to enhance the precision of climate simulations by optimizing a multi-model ensemble of General Circulation Models (GCMs) for simulating rainfall, maximum temperature (Tmax), and minimum temperature (Tmin). Bangladesh, with its susceptibility to rapid seasonal shifts and various forms of flooding, is the focal point of this research. Historical simulations of 19 CMIP6 GCMs are meticulously compared with ERA5 data for 1986–2014. The bilinear interpolation technique is used to harmonize the resolution of GCM data with the observed grid points. Seven distinct error metrics quantify the grid-to-grid agreement between GCMs and ERA5 data. The metrics are integrated into the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) for seasonal and annual rankings of GCMs. Finally, the ensemble means of top-performing models are estimated using Bayesian Model Averaging (BMA) and Arithmetic Mean (AM) for relative comparison. The outcomes of this study underscore the variability in GCM performance across different seasons, necessitating the development of an overarching ranking system. Results reveal ACCESS.CM2 is the preeminent GCM for rainfall, while INM.CM4.8 excels in replicating Tmax and UKESM1.0.LL in replicating Tmin. In contrast, FGOALS.g3, KACE.1.0.G and CanESM5 are the most underperformed models in estimating rainfall, Tmx and Tmn, respectively. Overall, there are five models, ACCESS.ESM1.5, ACCESS.CM2, UKESM1.0.LL, MRI.ESM2.0, EC.Earth3 performed best in simulating both rainfall and temperature. The relative comparison of the ensemble means of the top five models revealed that the accuracy of BMA surpasses AM in capturing rainfall and temperature spatial patterns. This study offers invaluable insights into the selection of GCMs and ensemble methodologies for climate simulations in Bangladesh. Improving the accuracy of climate projections in this region can contribute significantly to climate science.
Measuring Mean Frequency, Power, and Bandwidth: Key Parameters in Signal Analysis
Authors: Mohamedi Walid 
Published: January 2024

Abstract
Signal analysis plays a crucial role in various scientific, engineering, and technological domains, providing valuable insights into the characteristics of different signals. Among the fundamental parameters to be measured, mean frequency, power, and bandwidth stand out as key metrics. In this article, we delve into the significance of these parameters and the methods employed to measure them.
Conflicts of Interest Among Cardiology Clinical Practice Guideline Authors in Japan
Authors: Murayama Anju , Aizawa Megumi , Byreddy Keerthana R. , Higuchi Kenichi , Senoo Yuki 
Published: January 2024

Abstract
Background:
Clinical practice guidelines (CPGs) offer disease management recommendations based on scientific evidence. However, financial conflicts of interest (FCOIs) between CPG developers and the pharmaceutical industry could bias these recommendations, potentially affecting patient care. Proper management of these FCOIs is particularly crucial for maintaining the integrity of CPGs.
Objectives:
The study aimed to evaluate the extent of financial relationships between the pharmaceutical industry and authors of CPGs for cardiovascular diseases in Japan.
Methods:
The study analyzed personal payments from the pharmaceutical industry to authors of cardiovascular disease CPGs published by the Japanese Circulation Society (JCS) from January 2015 to December 2022. Payment data, including speaking, consultancy, and writing fees from 2016 to 2020, were extracted from a public available database containing personal payments disclosed by all major pharmaceutical companies.
Results:
A total of 929 unique authors from 37 eligible JCS CPGs were identified. Notably, 94.4% of these authors received personal payments from pharmaceutical companies, totaling over US$70.8 million. The mean and median payment per author was US$76,314 (standard deviation: US$138,663) and US$20,792 (interquartile range: US$4,262 – US$76,998) over the five-year period. Chairpersons of CPGs received significantly higher payments than other authors. More than 80% of authors in each CPG received personal payments.
Conclusions:
The study revealed extensive financial ties between pharmaceutical companies and cardiology CPG authors in Japan, with 94% of authors receiving significant payments. This finding deviates from international FCOI management policies, suggesting the need for more stringent COI management strategies by the JCS to ensure the development of trustworthy and evidence-based CPGs.
Clinicopathological and etiological characteristics for urinary tract infection in cervical cancer patients with radical surgery with double J stents
Authors: jin chengwen , xue yingfeng , bu hualei , xiang jiangdong , wu sufang , jin chengjuan 
Published: January 2024

Abstract
Background
To investigate the clinicopathological and etiological characteristics for urinary tract infection in cervical cancer radical surgery with indwelling ureteral stents.
Methods
A total of 24 patients who received cervical cancer radical surgery and retained with double J stent in Shanghai General Hospital from July 2018 to December 2022 were recruited as the study objects, the medical data were retrospectively analyzed, and the clinicopathological and etiological characteristics of the urinary tract infection were collected.
Results
Of the 24 cervical cancer patients with radical surgery patients with double J stent included in this study, 87.5% patients were locally advanced cervical cancer (LACC) and 73.91% patients received postoperative chemoradiotherapy. 58.33% patients had maximum diameter of cancer > 4cm and HPV 16 was present in 65% patients. Total 15 patients were complicated with urinary tract infection, with the infection rate reaching up to 62.5%. Postoperative adjuvant chemotherapy might be the risk factor for urinary tract infections, although no significant statistic difference was identified (P = 0.074). A total of 30 strains of pathogens were isolated from the patients with urinary tract infections. 10.00% were Gram-positive bacteria, 73.33% were Gram-negative bacteria, 16.67% were fungi. Escherichia coli were the most common pathogens of urinary tract infections. The Escherichia coli are resistant to ampicillin, ceftriaxone, cefotaxime, cefazolin and cefuroxime and sensitive to imipenem, meropenem, piperacillin/tazobactam, tigecycline and amikacin. Two strains of CRE (carbapenem resistant Enterobacteriaceae bacteria) were identified. 70.83% patients were inserted ureteral stents for 3 to 12 months. With the prolongation of ureteral stents placement, drug sensitivity for antibiotics targeting the same pathogen decreased and the pathogenic microbes changed from bacteria into fungi.
Conclusions
Ureteral tract infections were extremely high in LACC with radical surgery with ureteral stents insertion, with the rate reaching to 67.5%. Postoperative adjuvant chemotherapy might be the risk factor for urinary tract infections. The most common pathogens of urinary tract infections were Gram-positive bacteria, led by Escherichia coli. The Escherichia coli are relatively resistant to Penicillins and Cephalosporins and generally sensitive to Carbapenems and Glycylcyclines. This study could provide basis for clinicians to choose appropriate antibiotics for urinary tract infections during ureteral stents indwelling, preventing severe infections, reducing the burden of disease.
Study of the effect of temperature, pH, and time on the desorption of H2S.
Authors: CARRILLO DIEGO MARTINEZ , ÁVILA-ORTA CARLOS ALBERTO , RODRÍGUEZ JOSÉ CAÍN HERNANDEZ , ORTEGÓN LUIS FERNANDO CAMACHO , BERMEA CYNTHIA GUERRERO 
Published: January 2024

Abstract
Water is an inexhaustible natural resource, however, for use in human activities, it is required that its present certain characteristics that make it seem scarce. Hydrogen sulphide is a contaminant that occurs in well water making the water unusable for any human activity. Technology-marginalized areas that have this type of problem are affected by not having tools or equipment that can remove hydrogen sulphide from water. This study focuses on presenting an experimental design to determine the H2S removal kinetics under standard pressure conditions at different temperatures (23°C, 40°C and 50°C), observing that at 50°C up to 40% of the water evaporated. In addition, the effect of temperature (23°C and 40°C) and pH (7 and 11) on the removal of hydrogen sulphide was observed. An ANOVA was performed with the results obtained, determining that the significant variable in these tests was pH.
The Utility of Synoptic Operation Reports in Colorectal Surgery: A Systematic Review
Authors: Nikolic Amanda , Tranter Isaac , McCombie Andrew , Connor Saxon , Eglinton Tim 
Published: January 2024

Abstract

Purpose Accurate documentation is crucial in surgical patient care. Synoptic reports (SR) are structured checklist-based reports that offer a standardised alternative to traditional narrative reports (NR). This systematic review aims to assess the completeness of SR compared to NR in colorectal cancer (CRC) surgery. Secondary outcomes include the time to completion, surgeon satisfaction, educational value, research value, and barriers to implementation.Methods Prospective or retrospective studies that assessed SR compared to NR in colorectal cancer surgery procedures were identified through a systematic search of Ovid MEDLINE; Embase (Ovid); CIHNAL Plus with Full Text (EBSCOhost); and Cochrane. 1002 articles were screened, and eight studies met the inclusion criteria after full-text review of 17 papers.Results Analysis included 1797 operative reports (NR: 729; SR: 1068). Across studies reporting this outcome, the completeness of documentation was significantly higher in SR (P < 0.001). Reporting of secondary outcomes was limited, with a predominant focus on research value. Several studies demonstrated significantly reduced data extraction times when utilising SR. Surgeon satisfaction with SR was high, and these reports were seen as valuable tools for research and education. Barriers to implementation included integrating SR into existing electronic medical records (EMR) and surgeon concerns regarding increased administrative burden.Conclusions SR offer advantages in completeness, data extraction, and communication compared to NR. Surgeons perceive them as beneficial for research, quality improvement and teaching. This review supports the necessity for development of user-friendly SR that seamlessly integrate into pre-existing EMRs, optimising patient care and enhancing the quality of CRC surgical documentation.
Tracking water, sanitation, and hygiene (WASH) indicators in tribal districts of India: a secondary data analysis through 2015–2020
Authors: Tripathi Vinay , GS Preetha , Swain Sumant 
Published: January 2024

Abstract

Under Sustainable Development Goal targets 6.1 and 6.2, every nation is committed to ensure universal and equitable access to water and sanitation to its people and India is no exception. The country has made a considerable progress toward these targets through various policy and programmatic initiatives since 2015. Within an overall improvement at the country level, this paper examines the coverage of key WASH indicators in tribal population of the country. Secondary data pertaining to the WASH indicators were obtained from the NFHS 2015–2016 and NFHS 2019–2021 for 90 tribal-dominated districts of the country and were analyzed. We ranked these tribal districts on the basis of their performance. The analysis showed a distinct improvement in terms of marked fall in open defecation, uptake of improved toilet facilities, accessibility to improved sources of water, and improved behaviors in relation to the handwashing and treatment of drinking water in tribal population with varying levels of coverage, which was captured in WASH ranking of these districts. The districts falling toward the bottom side of the ranking ladder need prioritization and entail more attention of programmatic interventions in order to sustain the overall progress and to reach the SDG targets of 100% WASH coverage.
Interreligious Cooperation for Family Values: Latvian Experience
Authors: Stankevičs Zbigņevs 
Published: January 2024

The stimulus for writing the paper was an invitation to participate in the academic conference “St. John Paul II’s natural law legacy and international human rights: toward a century of persuasion”, organized by Cardinal Stefan Wyszynski University and Ave Maria International School of Law. I offered to share the Latvian experience of the last twenty-five years in the field of the defence of family values, taking into account cooperation between different religious communities in Latvia.
The study is based on selected international and Latvian law documents, as well as documents dealing with the issues raised and published in Latvian mass media. In the cited joint letters of religious leaders and my articles from 2002, an analysis is cited regarding the facts and materials in the field of defence of conceived life and family values. The article provides insights into the main topics discussed in Latvian society over the last two decades.
Does the Strasbourg European Court protect all human rights equally?
Authors: Borego Borego Javier 
Published: January 2024

The text opens with a recollection of St John Paul II's historic visit to a mosque in 2001, highlighting the cultural respect manifested the event. The text then delves into St John Paul II's early fascination with literature and drama, emphasizing his resistance to Nazi occupation through cultural means. The author quotes St John Paul II's statement that faith must become culture in order to be fully embraced and lived. The author urges the audience to approach Catholic culture wisely and quotes St John Paul II's encouragement not to be afraid of the future, emphasising the capacity for wisdom and virtue in individuals. The text then moves on to a critical analysis of the European Court of Human Rights , pointing out instances of procedural irregularities and dissenting views on judgements related to issues such as abortion and the recognition of civil marriage. The author then develops his argument by utilizing the format of a play, metaphorically titled 'Abdi Ibrahim v Norway', as a case study illustrating the impact of Islam on Europe , political correctness and social unrest.
CONVERGENCE ANALYSIS FOR APPROXIMATING SOLUTION OF VARIATIONAL INCLUSION PROBLEM
Authors: Dar Aadil Hussain , Younis Mudasir , Chen Lili 
Published: January 2024

This article aims to define a new resolvent operator for variational inclusion problems in the framework of Banach spaces. We design a rapid algorithm using the resolvent operator to approximate the solution of the variational inclusion problem in Banach spaces. Additionally, we show that the algorithm articulated in this article converges faster than the well-known and notable algorithm due to Fang and Huang. To show the superiority and prevalence of the obtained results, we propound a numerical and computational example upholding our claim. Lastly, a minimization problem is solved with the help of the proposed algorithm, which is the first attempt in the current context of the study.
LIGHTLIKE SUBMANIFOLDS OF AN INDEFINITE LORENTZIAN PARA-SASAKIAN STATISTICAL MANIFOLD
Authors: Ahmad Mobin , Alam Mahtab 
Published: January 2024

In this paper, we introduce an indefinite LP-Sasakian statistical manifold and study lightlike submanifold of an indefinite LP-Sasakian statistical manifold. We also introduce some relations among induced geometrical objects with respect to dual connections in a lightlike submanifold of an indefinite LP-Sasakian statistical manifold. One example related to this concept is also presented. Finally, we show that an invariant lightlike submanifold of an indefinite LP-Sasakian statistical manifold is an indefinite LP-Sasakian statistical manifold.
Legal Analysis of the Impact of Unregistered Marriage on Voter Data in Palu City
Authors: Megawati Megawati , Nurkhaerah Sitti , Markarma Andi 
Published: January 2024

The aim of the study is to describe sirri marriage as one of the factors in the problems that occur in voter data and the implications of the impact of sirri marriage on voter data in Palu City. The issues raised are how the implications of the impact of sirri marriages on voter data in Palu City and how the legal analysis of the results of sirri marriages on voter data in Palu City. The research method used is qualitative method and the data was gathered through field observation, in-depth interview, and documentation. The methodologyy was reinforced by the Maqashid Asy-Syariah approach. The results of the study indicate that sirri marriage is one of the problems with voter data, namely in the process of updating voter data. The impact is that it has a negative impact on the election process, namely the loss of voting rights, the occurrence of multiple voter list problems, and for children if there is no data recording, they also cannot be registered on the voter list. With the Minister of Home Affairs No. 8 of 2019, children from sirri marriages can record their identities, it's just that many other children's rights will be lost, it is better for the perpetrators of this sirri marriage and their children to be advised to do isbat marriage so that their marriage is recorded.
The Resolvent of Impulsive Singular Hahn–Sturm–Liouville Operators
Authors: Allahverdiev Bilender P. , Tuna Hüseyin , Isayev Hamlet A. 
Published: January 2024

Abstract
In this study, the resolvent of the impulsive singular Hahn–Sturm– Liouville operator is considered. An integral representation for the resolvent of this operator is obtained.
Non-dental study of the ‘functional matrix’ hypothesis
Authors: Mollenbauer Danielle I. 
Published: January 2024

Abstract
An exploratory study was undertaken to obtain data on arm measurements of competitive female tennis players (n = 30) at three age levels — prepubertal (10-12years), post-pubertal (16-18years) and mature (45-70years). They were matched with persons who did not play with racquets but who had generally played sport (non-racquet sports persons, n = 30). Comparisons were to be made between the arms they preferred for playing tennis with their other (non-preferred) arms, and with the arms of non-racquet sports persons. The results suggest that competitive female tennis players differ from non-racquet sports persons, in that these tennis players have ignificantly shorter preferred forearm bone length and greater preferred forearm girth measurements than the non-racquet persons, because their preferred forearrn length was longer. These findings were most prominent in the post-pubertal group, which indicates a study to explore the Epigenetic hypothesis using arms is justified. The fact that it was less prominent in the older age group could be explained by the observation that the older players did not stroke the ball as aggressively. The results of this study also indicated that there were no significant differences between tennis players and non-tennis players in ponderal indices, preferred grip strength or preferred elbow and wrist widths. Therefore the results suggest that the phenomenon should be studied in, rather than extrapolated to, the maxillo-facial region.
An Evaluation of Tomography, Cephalometrics and Casts in the Treatment of Temporomandibular Joint Disturbance
Authors: Williamson Eugene H. 
Published: January 2024

Abstract
This article summarizes the author’s approach to the use of radiography and dental casts in the diagnosis and treatment of temporomandibular joint disturbances. Dr Williamson was the main speaker at the Australian Society of Orthodontists’ Congress in Melbourne, in 1985.