bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Pannag, an Ancient Product of Israel
Authors: Eichler Raanan 
Published: February 2025

Abstract
The hapax legomenon פַּנַּג
pannag is mentioned in Ezekiel as an export of the land of Israel to the international market in Tyre (Ezek 27:17). It has been interpreted in wildly different ways, with the dominant view now being that it is a kind of baked good or flour. A few scholars have noted Greek πάνακες »allheal« as an apparent cognate, but they have not realized its significance. It is argued here that Hebrew pannag and its Akkadian cognate pinigu both derive from Greek πάνακες and denote a medicinal product of the Ferula (giant fennel) plant or of a related genus. Accordingly, pannag should be translated »allheal.«
Calcium carbonate-based biodegradable composites as an alternative material to industrial plastics
Authors: Ho Nathan , Huang Yi , Chung Eun Ji 
Published: February 2025

Abstract
Persistent pollution caused by conventional plastics poses significant risks to marine ecosystems and human health. Thus, there is a need for the development of biocompatible and biodegradable materials that mimic the properties of plastics that are also safe for environmental and public health. To address this, we engineered a plastic substitute by integrating calcium carbonate (CC), an abundant mineral naturally found in seashells, into poly (1,8-octanediol-co-citrate) (POC), a synthetic biodegradable elastomer already used as the binder of FDA-approved orthopedic fixation devices containing calcium minerals. We hypothesized that POC-CC is a biocompatible plastic substitute that can degrade in marine environments while maintaining sufficient strength for industrial applications. To test this, POC-CC was synthesized with varying CC concentrations (0, 15, 30 wt%). Weight degradation rate in ocean water, pH of ocean water after long-term incubation, elastic modulus, and the morphology of POC-CC using SEM was evaluated over 6 months. Our results show the degradation rate increases with increased POC content, and the addition of CC maintains the pH of ocean water. Additionally, to evaluate biocompatibility, Scenedesmus sp. algae was incubated with the POC-CC supernatant after incubation with simulated ocean water for six months. High cell viability was found, confirming the biocompatibility of POC-CC with marine microorganisms. Lastly, a model can holder was made with POC-CC to demonstrate its proof-of-concept as an alternative plastic material. In sum, we demonstrate POC-CC as a new material and the feasibility of its use as a biodegradable plastic alternative.

Graphical abstract
Occupation-based practice in a tertiary hospital setting: occupational therapists' perceptions and experiences.
Authors: Hess-April Lucia , Dennis, Lynique , Ganas Nicolette , Phiri Lungelo , Phoshoko Pumza 
Published: February 2025

Occupation-based practice is an important feature of occupational therapy. There is however limited research regarding occupational therapists' experiences with occupation-based practice. This study aimed to explore occupational therapists' perceptions and experiences regarding occupation-based practice in a tertiary hospital setting in the Western Cape, South Africa. An explorative and descriptive research design within a qualitative research approach was utilised. Purposive sampling allowed the selection of fourt participants with a minimum of 2 years practice experience. Semi-structured interviews were conducted to gain an understanding of how they perceived and implemented occupation-based practice. Data were analysed using thematic analysis. Four themes emerged: occupation-based practice expresses professional identity; occupation-based practice necessitates relevance; constraints to occupation-based practice; and facilitators of occupation-based practice. The findings revealed that the participants' perceived the implementation of occupation-based practice as an expression of their professional identity and that in adopting an occupation-based approach they perceived their roles as diverse and transformational. It was however highlighted that the nature of the service context posed several constraints that influenced the implementation of occupation-based practice. Thus, occupational therapists may need to generate practice-based evidence to advocate for the service conditions necessary to implement occupation-based practice and deliver relevant occupational therapy services.Â Key words: Occupation; occupation-based practice; tertiary hospitals; qualitative research
The effects of rehabilitation education for village health volunteers on walking speed and upper-extremity function in stroke survivors in Thailand
Authors: Chinchai Pisak , Khamwong Peanchai 
Published: February 2025

Introduction: Stroke can cause long-term disabilities to survivors. Rehabilitation is an on-going process and should, ideally, be provided to these people in their homes. This study aimed to investigate the effect that rehabilitation education provided to village health volunteers (VHVs) would have on walking speed and upper extremity (UE) function in stroke survivors who stay at home in Thailand.Methods: Participants were recruited by purposive sampling, which included 27 stroke survivors from four municipalities in Chiang Mai and Lamphun provinces. The measuring instruments used were the Ten-Meter Walk Test and the UE motor domain of the Fugl-Meyer Assessment. Researchers presented a 7-hour rehabilitation education programme to VHVs, who then made weekly 1-hour visits to the homes of stroke survivors to implement the rehabilitation programme over eight weeks. Data were collected within seven days before and then again after the 8-week programme. Results: Descriptive statistics and the paired t-test were applied to analyse the data. Results showed that the participants usedsignificantly less walking time from pre-test ( X =34.73Â±8.48) to post-test ( X =32.18Â±9.32) (p<0.05). However, the score of UEfunction at pre-test ( X =36.81Â±9.59) was not significantly different from that at post-test ( X =37.26Â±9.67).Conclusion: The findings suggest that trained VHVs can be part of the rehabilitation team and contribute to improved functional performance for disabled stroke survivors, particularly in developing countries
Reconstruction of finger function in case of joint defects
Authors: Volkova Yu. S. , Rodomanova L. A. 
Published: February 2025

Introduction Repair of bone defects in the hand is still a challenge despite advancements in hand surgery and improved surgical techniques. However, the main difficulty still lies in restoring the function of the injured segment when the defect affects functionally significant joints including the proximal interphalangeal and metacarpophalangeal joints of the fingers. Loss of mobility in the joints significantly impairs the physical capabilities of patients and the quality of life. A reconstructive intervention is primarily aimed at restoration of the useful range of motion of the involved finger with minimal risks of postoperative complications.The objective was to evaluate the possibilities with finger function restoration and the effectiveness of the techniques used to repair defects in the fingers joints based on literature analysis.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru) and the National Library of Medicine (www.pubmed.org), Elseiver, Google Scholar (2008 to 2024) and using keywords: finger joint defects, bone loss, intra-articular injuries of the fingers, arthroplasty, small joint replacement, reconstruction of finger joints, joint restoration, metacarpophalangeal joint, proximal interphalangeal joint, bone graft, joint transplantation, joint transfer, microsurgery, vascular bone joint transfer. Sixty articles by foreign authors and 11 publications of Russian researchers were selected for analysis.Results and discussion With the variety of surgical techniques, there is no universal method for replacing defects in the finger joints. Along with the high rate of postoperative complications, the lack of an optimal method requires careful preoperative planning. Reconstructive interventions should be considered as a method of choice and an alternative to arthrodesis in young, physically active patients. Limited postoperative range of motion in the reconstructed joint is a challenge in the treatment of patients with this pathology. The choice of surgical strategy relies on the patient’s compliance for a complex and lengthy rehabilitation in achievement of a functionally satisfying result.Conclusion Reconstructive interventions for repair of a bone defect in the joint are practical for increasing the useful range of motion of the involved finger and improving the physical capabilities of the hand.
Elution of antibiotics from bone cement: problems and ways to solution
Authors: Shafigulin R. A. , Akhtyamov I. F. , Emelin A. L. , Bespalov I. A. , Akifyev K. N. 
Published: February 2025

Introduction The widespread use of bone cement in the treatment of patients with orthopedic infections can be associated with limited elution of antibiotics with use of local spacers.The objective was to determine problems of elution of antibiotics from bone cement and ways to solve them based on literature data.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru) and the National Library of Medicine (www.pubmed.org) (1994 to 2024) and using keywords: bone cement, PMMA, polymethylmethacrylate, antibiotic elution, bone cement, antibiotic elution, additive manufacturing, porous constructions, lattice structures. The sources were included based on the hypothesis that preformed implants based on a lattice structure could be used in combinations with bone cement.Results and discussion The elution of antibiotics from bone cement can be improved through examination of the cement type, the porosity, the implant/spacer shape, the type of antibiotics, quantities and combinations administered that pose a difficult scientific problem in the absence of an acceptable solution along with the variety of publications. However, research in this area has not led to any complete solution.Conclusion A paradigm has been developed for improving the elution of antibiotics from polymethyl methacrylate (PMMA) to include working with the cement: its composition, geometry and pyrogenicity. Solutions offered for improving the elution of antibiotics from PMMA are often impracticable and can deteriorate the performance properties of cement. Another approach can involve a research aimed at studying the effectiveness of spacers with a preformed base and bone cement coating, without or with minimal interference with the properties specified by the manufacturer.
Possible application of glassy carbon composite scaffolds in bone tissue engineering
Authors: Timoshchuk E. I. , Ponomareva D. V. , Gareev A. R. 
Published: February 2025

Introduction Bone defect management remains one of the challenging problems of regenerative medicine, for the solution of which the most promising trend is the use of tissue-engineered implants based on composite scaffolds that stimulate osteogenesis. One of the main tasks of tissue engineering is the development of a scaffold that mimics three-dimensional architecture for osteogenic progenitor cells inside the scaffold, with the possibility of cell interaction with appropriate chemical and physical stimuli of natural bone.The purpose of the work is to evaluate the possibility of using composite scaffolds based on glassy carbon in tissue engineering.Materials and Methods This study describes a reproducible method of obtaining three-dimensional porous glass-carbon-based scaffolds with surfaces modified with pyrocarbon (CF-C) and pyrocarbon and hydroxyapatite (CF-C-HAP) and investigates the porosity, strength characteristics, cytotoxicity, and osteoinductivity of the composite scaffolds obtained. Osteogenic differentiation of cultured human mesenchymal stem cells (MSCs) was evaluated on CF-C and CF-C-HAP scaffolds using common osteogenic markers such as: alkaline phosphatase (ALP) activity, alizarin red staining and quantitative real-time PCR (qPCR).Results In vitro studies showed the biocompatibility of the developed scaffolds. The ability of CF-C-HAP to induce MSC differentiation in osteogenic direction and to produce calcium-containing matrix was established.Discussion The scaffolds based on glassy carbon foam with pyrocarbon and hydroxyapatite coatings have a three-dimensional structure with open porosity, along with the strength comparable to the strength of the replaced tissue, and imitate the structure of trabecular bone. However, the strength of glassy carbon foam without coating is characterized by low compressive strength. All the studied materials demonstrated adhesive and proliferative activity of MSCs, high cell adhesion and absence of cytotoxicity. Determination of the mRNA expression level by real-time PCR showed that after 14 days, cells cultured on CS-C-HAP showed expression of the VDR, BMP7, IGFR1, SPP1 genes, what demonstrates osteogenic potential. The results of our studies on phosphatase activity and alizarin red staining demonstrated that the CF-C‑HAP scaffold stimulates osteoblast differentiation in vitro in the osteogenic direction, as well as intracellular mineralization processes.Conclusion Composite CF-C-HAP scaffolds based on glassy carbon foam support cell proliferation and differentiation and may be promising for use in bone tissue engineering.
Histomorphometric characteristics of the metaepiphyseal plate of the distal femur of lambs during the period of their intensive growth
Authors: Stupina T. A. , Dyuryagina O. V. , Korobeynikov A. A. 
Published: February 2025

Introduction Growth zone injuries are quite common and account for 15–30 % of all skeletal bone injuries in children. Complications occur in 2–14 % of patients. An adequate experimental animal model is needed to develop new methods for treating growth zone injuries. The purpose of the work is to identify patterns in the dynamics of histomorphometric characteristics of the metaepiphyseal cartilage of the distal femur of lambs during the period of their intensive growth.Materials and methods The metaepiphyseal cartilage of the distal femur of 12 lambs (aged 3.5 and 5.5 months, 5 males and 7 females) previously participating in an experiment on the effect of osteosynthesis pins on the structural reorganization of the metaepiphyseal cartilage was studied. Histological, immunohistochemical, and histomorphometric studies were performed.Results The zonal structure of the metaepiphyseal plate along with an increased proportion of PAS-positive structures in the outer layer of the border zone and in the calcified cartilage zone were determined. Masson staining revealed fuchsinophilic areas of the border zone matrix in the metaepiphyseal cartilage of animals aged 5.5 months, as well as an increase in the proportion of fuchsinophilic areas of the calcified cartilage zone compared to animals aged 3.5 months, which indicated increased mineralization. CD34 expression at 3.5 months was detected in the outer layer of the border zone, at 5.5 months the depth of vascular invasion increased, but did not reach the proliferating cartilage zone. A decrease in the thickness of the metaepiphyseal cartilage at the age of 5.5 months by an average of 18.2 % is due to a decrease in the thickness of the border zone by 1.9 times, while the thickness of the proliferating cartilage zone increased by 1.2 times.Discussion The changes observed in the main substance of the metaepiphyseal cartilage indicated that the processes of matrix calcification are more intense in lambs by the age of 5.5 months. The depth of vascular penetration from the diaphysis is more pronounced than from the epiphysis. Fractures in the growth zone during the period of intensive growth can be caused by the predominance of the border zone and by the proliferating cartilage zone.Conclusion Histomorphometric changes in the metaepiphyseal plate of the distal femur of lambs during the period of their intensive growth were characterized by a decrease in its thickness due to a marked decrease in the thickness of the reserve zone, while the thickness of the proliferating cartilage statistically significantly increased. The depth of vascular invasion in the border zone increased, but did not reach the proliferating cartilage zone, changes in the tinctorial characteristics of the ground substance indicated the activation of matrix calcification processes from the subchondral bone of the epiphysis and endomorphic ossification from the diaphysis.
First experience with the use of a partially bioresorbable bone substitution material in a patient with 34-year old chronic osteomyelitis of the tibia
Authors: Sudnitsyn A. S. , Shastov A. L. , Klushin N. M. , Rashidov G. Kh. 
Published: February 2025

Introduction The most common approach to the treatment of osteomyelitic cavities (Cierny – Mader type III) is a two-stage approach proposed by Masquelet, the main shortcoming of which is the need to perform a second surgical intervention which results in a longer rehabilitation period, increased economic costs and additional emotional distress of the patient. In electronic databases, we found 17 publications devoted to the use of partially bioresorbable materials for filling in uncomplicated bone defects. The experience of treatment of chronic osteomyelitis (Cierny – Mader type III) using such materials has not been described.Purpose Demonstration of the first use of a partially bioresorbable osteosubstituting material in a one‑stage treatment of a patient with a long-term osteomyelitic process after failures of conventional surgical treatment methods.Materials and methods We present a case of a 54-year old patient with a diagnosis of chronic post-traumatic osteomyelitis of the right leg, fistulous form, associated with contracture of the right ankle joint, 2-cm shortening of the right lower limb. A one-stage treatment technique was used using a partially bioresorbable osteosubstituting material for the first time in combination with antibacterial drugs, preselected in accordance with the patient's microbial cultures.Results The study evaluated the use of a partially bioresorbable material impregnated with antibacterial drugs in the treatment of a patient with osteomyelitic cavity Cierny – Mader type III that achieved stable arrest of purulent and inflammatory process.Discussion The mandatory two-stage Masquelet approach increases the surgical aggression, requires collection of an autologous bone graft, thus the risk of possible complications becomes higher. The obvious advantages of bioresorbable materials impregnated with antibacterial drugs to fill in bone defects are: no need to collect an autograft, a reduction in the number of surgical interventions to one, the possibility of gradual natural degradation of the implant from the patient's body due to bioresorption. Conclusion The study demonstrates the potential use of partially bioresorbable materials in a one-stage technology for treating patients with Cierny – Mader type III osteomyelitic cavities.
Clinicoepidemiological study of pre malignant and malignant lesions among patients attending the dermatology OPD in a tertiary care centre in Puducherry: a retrospective cross-sectional study
Authors: M. Trishna Vaishali , P. Nithiyaa , J. Sheron Christin Armel 
Published: February 2025

Background: The growing prevalence of skin cancer worldwide can be understood as the result of increased exposure to ultraviolet radiation. Fitzpatrick skin type 1 and 2 are at higher risk. They are poorly studied in Asians. Skin cancers accounts for 20%-30% of neoplasms in Caucasians and 2%-4% in Asians. Three million cases of non-melanoma skin cancer and 132 thousand melanomas are diagnosed worldwide every year. The aim of the study is to study the profile of patients with premalignant and malignant skin lesions visiting the dermatology OPD in Puducherry for a period of 3 years.
Methods: Case records of 57,316 patients were studied. 82 case records of premalignant and malignant skin lesions were reviewed and analysed using SPSS software. The prevalence was calculated and also their distribution among age, gender and race was analysed.
Results: 82 cases with 93 premalignant and malignant skin lesions were recorded. 77.4% (n=72) were premalignant lesions and 22.5% (n=21) were malignant lesions. The commonest premalignant lesion was leukoplakia (n=38, 52.78%) followed by actinic Keratosis (n=31, 43.05%), keratoacanthoma (n=2, 2.78%) and Bowens disease (n=1, 1.39%). The commonest malignant tumor in the study was basal cell carcinoma (n=12, 57.14%), followed by squamous cell carcinoma (n=9, 42.86%). There were no melanomas or lymphomas reported during the study period.
Conclusions: The index of suspicion for the atypical presentations and earlier identification of the premalignant and malignant skin lesions can aid in the selection of appropriate treatment modality and thereby reducing their associated morbidity and mortality.
Penerapan Cooperative Learning Tipe STAD, Guided Inquiry dan Problem Based Learning dalam Perspektif Kristen [The Implementation of STAD-Type Cooperative Learning, Guided Inquiry and Problem Based Learning in Christian Perspective]
Authors: Sianipar Lanny , Tampubolon Meliana Rodearni , Polak Aurelia Friscilla , SUWU Selvi Esther , Chrismastianto Imanuel Adhitya Wulanata 
Published: February 2025

School and learning are inseparable. Meaningful learning looks at several aspects in its implementation, such as the school environment, classroom management, student character to the model or lesson method used. Teachers in this case play a role as agents of reconciliation who can introduce God to their students in the classroom, this can also start from the teacher choosing a learning model. One of the learning models that can be chosen is cooperative learning which uses a model of cooperation in learning. There are various kinds of cooperative learning models, but in this study, there are three discussed. Thus, the purpose of this research is to find out the cooperative learning type STAD, Guided Inquiry and Problem based Learning in Christian perspective. With the literature review method, the results of this study are that the use of the STAD learning model has a positive impact on students, and by the philosophy of Christian education emphasizes the importance of human relations with others as the image and likeness of God. The application of the guided inquiry learning model requires the active involvement of a teacher to guide students both cognitive, social, emotional, and spiritual in learning. Project-based learning in its implementation is expected to be able to direct students to holistic growth in accordance with the role of Christian teachers in the discipleship process.