bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Voice Outcomes for Two Voice Rest Protocols after Phonomicrosurgery
Authors: Fan Ruiqing Stephanie , Yiu Yin , Kulesz Paulina A. , Dueppen Abigail , Procter Teresa , Goodwin Maurice E. , Thekdi Apurva A. , Joshi Ashwini 
Published: January 2024

ObjectivesVoice rest is commonly recommended for patients with benign vocal fold lesions (BVFLs) after phonomicrosurgery. The study compares the clinical voice outcomes of two protocols, 7‐day complete voice rest (CVR) and 3‐day CVR followed by 4‐day relative voice rest (CVR + RVR), for patients with BVFLs after phonomicrosurgery.Study DesignProspective, randomized controlled trial.MethodPatients with BVFLs undergoing phonomicrosurgery were recruited prospectively and randomly assigned to either protocol. Outcomes were assessed on objective measures of acoustics (fundamental frequency, frequency range, mean intensity, cepstral peak analysis) and aerodynamics (vital capacity, airflow rate, subglottal pressure, phonation threshold pressure), as well as subjective measures, both provider‐reported through the Consensus Auditory‐Perceptual Evaluation of Voice (CAPE‐V), and patient‐reported through the Voice Handicap Index (VHI). Clinical measures were collected at three‐time points: preoperatively, 1‐week postoperatively (on voice rest), and 1‐month postoperatively. In addition, adherence was estimated using a vocal dosimeter.ResultsTwenty‐five patients were recruited and randomized to 7‐day CVR (n = 13) and CVR + RVR regimen (n = 12). Statistically significant changes were found within both groups for subglottal pressure (p = 0.03) and VHI score (p < 0.001) comparing pre‐operative baseline to 1‐month postoperative follow‐up. There were no statistically significant differences between the groups. Regardless of group assignment, a significant decrease in overall severity ratings for the CAPE‐V was found by comparing the preoperative scores to postoperative scores at 1‐week (p < 0.001) and 1‐month (p < 0.001).ConclusionBoth groups improved their overall voice quality comparably 1 month after undergoing phonomicrosurgery as measured by objective and subjective parameters.Levels of Evidence2. Laryngoscope, 134:2812–2818, 2024
Assessing Facial Palsy: Does Feedback Improve Assessment Using the eFACE and Sunnybrook Facial Grading System?
Authors: Bruins Tessa E. , Lammens Romy F. , van Veen Martinus M. , Tamási Katalin , Dijkstra Pieter U. , Werker Paul M.N. , Broekstra Dieuwke C. 
Published: January 2024

Objective(s)To explore learning effects when applying the clinician‐graded electronic facial function scale (eFACE) and the Sunnybrook Facial Grading System (Sunnybrook).MethodsSurgeons, facial rehabilitation therapists, and medical students were randomly allocated to the eFACE (n = 7) or Sunnybrook (n = 6) and graded 60 videos (Massachusetts Eye and Ear Infirmary open‐source standard set); 10 persons with normal facial function and 50 patients with a wide variation of facial palsy severity. Participants received an introduction and individual feedback after each set of 10 videos. Scores were compared to the reference score provided with the set. Multilevel analysis was performed to analyze learning effect.ResultsA learning effect was only found for the eFACE, with significant difference scores in set 1 and 2 compared to set 6, and no significant difference scores in the following sets. The difference score was associated with the reference score (severity of facial palsy) for eFACE (β = −0.19; SE = 0.04; p < 0.001) and Sunnybrook (β = −0.15; SE = 0.04; p < 0.001). Age of participants was also associated with the difference score in the eFACE group (β = 0.18; SE = 0.03; p < 0.001). No differences in scores were found between groups of participants.ConclusionThe eFACE showed a learning effect of feedback while the Sunnybrook did not.Level of EvidenceNA Laryngoscope, 134:3105–3111, 2024
Editorial actions taken to reduce publishing references from predatory sources: A case study
Authors: Dodgson Joan E. , Bamberger Ethan T. , Haile Zelalem T. , Kornegay Mary Kate J. 
Published: January 2024

Key points
Our policy and implementation successfully identified references from predatory publishers, which authors without hesitation agreed to remove before publication.
Higher predatory reference patterns emerged among authors in low‐income countries, those with non‐English primary languages, and sole authorship.
After a year of implementing our policy, the editors changed our policy and workflow to better handle references from predatory publishers cited in literature reviews and meta‐analyses.
Editorial responsibility is discussed, particularly concerning support for authors from lower‐ and middle‐income countries.
Chiral Lithography with Vortex Non‐diffracted Laser for Orbital Angular Momentum Detection
Authors: Li Jiaqun , Yan Jianfeng , Jiang Lan , Qu Liangti 
Published: January 2024

AbstractChiroptical response, demonstrating chiral interaction between optical vortex and chiral structure, plays an important role in variety of fields like optics and material science. However, the flexibility and efficiency of chiral structure fabrication are limited due to mask requirement and a point‐by‐point constructing strategy. In this paper, a novel chiral lithography method is proposed that utilizes optical vortex phase beam shaping to achieve chiral structure processing with high efficiency and flexibility. By programming topological charges of the vortex phase, chiral structures with adjustable appearance, rotation, and chirality can be produced using femtosecond laser single pulse exposure. Transmittance measurements of fabricated chiral structures array confirm a 66% helical dichroism that is predicted by simulation. Moreover, with the aid of convolutional neural networks (CNN), an accuracy of 98% in Orbital Angular Momentum (OAM) recognition can be achieved. This chiral lithography method provides an alternative for chiral structure fabrication and holds promise in the development of chiral optics, optical communications, and next‐generation optical devices.
DNA Crosslinked Mucin Hydrogels Allow for On‐Demand Gel Disintegration and Triggered Particle Release
Authors: Henkel Manuel , Kimna Ceren , Lieleg Oliver 
Published: January 2024

AbstractWhereas hydrogels created from synthetic polymers offer a high level of control over their stability and mechanical properties, their biomedical activity is typically limited. In contrast, biopolymers have evolved over billions of years to integrate a broad range of functionalities into a single design. Thus, biopolymeric hydrogels can show remarkable capabilities such as regulatory behavior, selective barrier properties, or antimicrobial effects. Still, despite their widespread use in numerous biomedical applications, achieving a meticulous control over the physical properties of macroscopic biopolymeric networks remains a challenge. Here, a macroscopic, DNA‐crosslinked mucin hydrogel with tunable viscoelastic properties that responds to two types of triggers: temperature alterations and DNA displacement strands, is presented. As confirmed with bulk rheology and single particle tracking, the hybridized base pairs governing the stability of the hydrogel can be opened, thus allowing for a precise control over the hydrogel stiffness and even enabling a full gel‐to‐sol transition. As those DNA‐crosslinked mucin hydrogels possess tunable mechanical properties and can be disintegrated on demand, they can not only be considered for controlled cargo release but may also serve as a role model for the development of smart biomedical materials in applications such as tissue engineering and wound healing.
It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms
Authors: Su Yajuan , Shahriar Shatil S. M. , Andrabi Syed Muntazir , Wang Chenlong , Sharma Navatha Shree , Xiao Yizhu , Wong Shannon L. , Wang Guangshun , Xie Jingwei 
Published: January 2024

AbstractWound biofilms pose a great clinical challenge. Herein, this work reports a dissolvable microneedle patch for dual delivery of monoclonal antibodies anti‐PBP2a and engineers antimicrobial peptides W379. In vitro antibacterial efficacy testing with microneedle patches containing a combination of 250 ng mL−1 W379 and 250 ng mL−1 anti‐BPB2a decreases the bacterial count from ≈3.31 × 107 CFU mL−1 to 1.28 × 102 CFU mL−1 within 2 h without eliciting evident cytotoxicity. Ex vivo testing indicates W379 and anti‐PBP2a co‐loaded microneedle patch displayed a remarkable reduction of bacterial load by ≈7.18 log CFU after administered only once within 48 h. The bacterial count is significantly diminished compared to the treatment by either W379 or anti‐PBP2a‐loaded alone microneedle patches. When administered twice within 48 h, no bacteria are identified. Further in vivo study also reveals that after two treatments of W379 and anti‐PBP2a co‐loaded PVP microneedle patches within 48 h, the bacterial colonies are undetectable in a type II diabetic mouse wound biofilm model. Taken together, W379 and anti‐PBP2a co‐loaded PVP microneedle patches hold great promise in treating wound biofilms.
Influence of sample thickness and microstructure on metal dusting behavior of NiCrFeAl alloys
Authors: Hattendorf Heike , Hermse Chrétien G. M. , IJzerman Richard M. 
Published: January 2024

AbstractSamples of alloy 601, 602 CA and 602 MCA with different thickness and microstructure, all 600 grit laboratory ground, are compared. All samples are exposed to up to 5693 h at 600°C in a metal dusting producing atmosphere with a total pressure of 20 bar. A smaller sample thickness leads to an increased pit density for alloy 601 and an increased pit density, a longer incubation time and an increased pit depth growth rate for alloy 602 CA. This is attributed to lower stresses in the scale of the thinner samples. Grain size effects of the substrate are probably concealed by the deformed and recrystallized subsurface due to the 600 grit finish of the samples. If carbides are unavoidable in an alloy, they should be small, as they can serve as chromium suppliers during scale formation better than larger ones. They increase incubation time and pit depth growth rate.
Effect of Chitosan on the Microstructural Properties of Zinc Ferrite Nanoparticles
Authors: Aisida Samson O. , Gospel Ezeakunne Chidozie , Alshoaibi Adil , Okeudo David , Ijeh Rufus , Ezema Fabian I. 
Published: January 2024

AbstractThis study presents the effect of chitosan on the properties of zinc ferrite nanoparticles suitable for potential biomedical applications. The co‐precipitation method is employed to fabricate these bio‐composites that exhibit excellent microstructural properties. The X‐ray diffractometer (XRD) analysis confirms the presence of a cubic spinel structure in the zinc ferrite‐chitosan bio‐composites, indicative of their crystalline nature. Scanning electron microscope (SEM) imaging revealed spherical particles with a size distribution below 100 nm, demonstrating the successful synthesis of homogenous nanosized particles. Fourier transform infrared spectroscopy (FTIR) spectroscopy analysis identifies the active functional groups within the bio‐composites, providing valuable insights into the molecular structure and interactions present in the synthesized materials. The presence of chitosan is confirmed, highlighting its role in modifying the chemical composition and enhancing the biocompatibility of the samples. UV–vis absorption spectra analysis reveals that the samples exhibits absorbance within the visible range. Vibrating sample magnetometer (VSM) analysis demonstrates the superparamagnetic behavior of the samples. Remarkably, these formulated samples exhibit superparamagnetism with zero coercivity and a magnetization of ≈0.0125 emu g−1 at 5 kOe when doped with chitosan. These properties are crucial for potential biomedical applications making it a promising candidate for various biomedical applications.
A high‐efficiency power amplifier by using harmonics control
Authors: Guo Long , Wang Guangming , Shi Yiping 
Published: January 2024

AbstractA harmonics control high‐efficiency power amplifier (PA) is proposed by combining an asymmetrical branch‐line coupler (ABLC) and a shunt transmission line. With the special ports impedance condition, the ABLC realizes impedance transformation as well as shorts even‐harmonics, and the shunt transmission line shorts the third harmonic. Herein, two‐stage couplers not only expand the bandwidth but also enhance the harmonics control. A PA is simulated and fabricated to verify the proposed method. The measured results show that the typical saturated output power is more than 40 dBm, the drain efficiency is 60.3%–81.3%, and the power gain is 10.4–17.9 dB from 1.4 to 2.4 GHz.
A moisture detection sensor for flour based on the gas in scattering media absorption spectroscopy
Authors: Guo Xu , Meng Xingxing , Li Long , Qiu Xuanbing , Li Chuanliang , Guo Guqing , Sun Xiaocong , Gong Ting , Tian Yali 
Published: January 2024

AbstractFlour is an essential ingredient in human daily diet, thus it is crucial to measure its moisture content. However, current detection methods are time‐consuming and labor‐intensive, hindering quick measurement. Here we demonstrate the measurement of moisture content in flour via gas in the scattering media absorption spectroscopy (GASMAS) technique. A compact sensor that includes distributed feedback laser driver, cuvette, photodetector, analog lock‐in amplifier, and analysis processing module is developed. We measure the equivalent mean path length of various flour samples, and verify the measurement sensitivity of GASMAS by studying its dependence on moisture content. A linear relationship between path length and moisture content is established by least‐squares curve fitting, corresponding to a correlation coefficient of 0.996. Compared to the drying method, our method shows a maximum error range of 6.1% for all samples, providing a highly accurate and reliable measurement of water content in flour.
Estimating ventilation correlation coefficients in the lungs using PREFUL‐MRI in chronic obstructive pulmonary disease patients and healthy adults
Authors: Moher Alsady Tawfik , Ruschepaul Jakob , Voskrebenzev Andreas , Klimes Filip , Poehler Gesa Helen , Vogel‐Claussen Jens 
Published: January 2024

AbstractPurposeVarious parameters of regional lung ventilation can be estimated using phase‐resolved functional lung (PREFUL)‐MRI. The parameter “ventilation correlation coefficient (Vent‐CC)” was shown advantageous because it assesses the dynamics of regional air flow. Calculating Vent‐CC depends on a voxel‐wise comparison to a healthy reference flow curve. This work examines the effect of placing a reference region of interest (ROI) in various lung quadrants or in different coronal slices. Furthermore, algorithms for automated ROI selection are presented and compared in terms of test–retest repeatability.MethodsTwenty‐eight healthy subjects and 32 chronic obstructive pulmonary disease (COPD) patients were scanned twice using PREFUL‐MRI. Retrospective analyses examined the homogeneity of air flow curves of various reference ROIs using cross‐correlation. Vent‐CC and ventilation defect percentage (VDP) calculated using various reference ROIs were compared using one‐way analysis of variance (ANOVA). The coefficient of variation was calculated for Vent‐CC and VDP when using different reference selection algorithms.ResultsFlow‐volume curves were highly correlated between ROIs placed at various lung quadrants in the same coronal slice (r > 0.97) with no differences in Vent‐CC and VDP (ANOVA: p > 0.5). However, ROIs placed at different coronal slices showed lower correlation coefficients and resulted in significantly different Vent‐CC and VDP values (ANOVA: p < 0.001). Vent‐CC and VDP showed higher repeatability when calculated using the presented new algorithm.ConclusionIn COPD and healthy cohorts, assessing regional ventilation dynamics using PREFUL‐MRI in terms of the Vent‐CC metric showed higher repeatability using a new algorithm for selecting a homogenous reference ROI from the same slice.
The effects of residual dipolar coupling on carnosine in proton muscle spectra
Authors: Lievens Eline , Van Vossel Kim , Van de Casteele Freek , Derave Wim , Murdoch James B. 
Published: January 2024

AbstractCarnosine, an MR‐visible dipeptide in human muscle, is well characterized by two peaks at ~8 and ~7 ppm from C2 and C4 imidazole protons. Like creatine and other metabolites, carnosine is subject to residual dipolar coupling in the anisotropic environment of muscle fibers, but the effects have not been studied extensively. Single‐voxel TE 30–32 PRESS spectra from three different 3T studies were acquired from gastrocnemius medialis and soleus muscles in the human lower leg. In these studies, carnosine T2 values were measured, and spectra were obtained at three different foot angles. LCModel was used to fit the carnosine peaks with a basis set that was generated using shaped RF pulses and included a range of dipolar couplings affecting the C4 peak. A seven‐parameter analytic expression was used to fit the CH2 doublets of creatine. It incorporated an optimized “effective TE” value to model the effect of shaped RF pulses. The fits confirm that the triplet C4 peak of carnosine is dipolar coupled to a pair of CH2 protons, with no need to include a contribution from a separate pool of freely rotating uncoupled carnosine. Moreover, the couplings experienced by carnosine C4 protons and creatine CH2 protons are strongly correlated (R2 =  0.88, P<0.001), exhibiting a similar 3cos2θ − 1 dependence on the angle θ between fiber orientation and B0. T2 values for the singlet C2 peak of gastrocnemius carnosine are inversely proportional to the C4 dipolar coupling strength (R2 = 0.97, P < 0.001), which in turn is a function of foot orientation. This dependence indicates that careful positioning of the foot while acquiring lower leg muscle spectra is important to obtain reproducible carnosine concentrations. As proton magnetic resonance spectroscopy of carnosine is currently used to non‐invasively estimate the muscle fiber typology, these results have important implications in sport science.
Beyond assumptions of altruism: Examining nonprofit work with a job fit framework and response surface analysis
Authors: Oelberger Carrie 
Published: January 2024

AbstractScholars frequently investigate how nonprofit employees, as a group, differ from public or for‐profit employees. However, there is less focus on how motivational profiles vary among nonprofit employees. Particularly as the nonprofit sector professionalizes, the reasons why people seek nonprofit employment are diversifying. Recent work highlights a more individualized understanding of employee motivation, which can lead to more nuanced and tailored human resource management techniques. I amplify this stream of scholarship, guided by a job fit framework and introducing a robust methodological approach from organizational psychology that accounts for interactions between an employee's work preferences and work experiences on outcomes of interest. With two waves of original data on international aid workers, I demonstrate that the experience of prosocial work (i.e., work that aims to help other people) is associated with greater job satisfaction for those with strong prosocial work preferences but can be associated with reduced job satisfaction for those without. These findings necessitate nuanced attention to employees' work preferences, moving beyond assumptions that prosocial work will universally motivate nonprofit employee performance.
Outcomes of adverse childhood experience during late adolescence: Evidence from college and community samples
Authors: Almaradheef Rana , Alhalal Eman 
Published: January 2024

AbstractScant studies have investigated adverse childhood experience (ACE) outcomes and mastery during adolescence in different cultural contexts. This cross‐sectional study examines the impact of ACEs on subjective well‐being, health complaints, and healthcare utilization during late adolescence, including the mediating role of the sense of mastery in the Saudi context. Adolescents (N = 396) aged 17–21 years were recruited via convenience sampling from colleges and local communities from two regions in Saudi Arabia. Data were collected using a paper‐pencil anonymous survey and analyzed using path analysis. Of the sample, 85.5% experienced at least one ACE. ACEs had a direct effect on subjective well‐being (p = 0.034), health complaints (p < 0.001), healthcare utilization (p < 0.001), and sense of mastery (p < 0.001). Sense of mastery had an effect on subjective well‐being (p < 0.001) and health complaints (p < 0.001), but not on healthcare utilization (p = 0.436). Sense of mastery partially mediated the relationship between ACEs and subjective well‐being (p = 0.034) and health complaints (p < 0.001), but not healthcare utilization (p = 0.438). ACEs have detrimental effects on adolescent health. Attention should be paid to primary prevention and early detection to avoid further harm, and interventions that address the role of the sense of mastery should be developed for adolescents.
Busulfan with 400 centigray of total body irradiation and higher dose fludarabine: An alternative regimen for hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia
Authors: Gharial Jaspreet , Guilcher Gregory , Truong Tony , Shah Ravi , Desai Sunil , Rojas‐Vasquez Marta , Kangarloo Bill , Lewis Victor 
Published: January 2024

AbstractBackgroundHematopoietic stem cell transplantation can be curative for children with difficult‐to‐treat leukemia. The conditioning regimen utilized is known to influence outcomes. We report outcomes of the conditioning regimen used at the Alberta Children's Hospital, consisting of busulfan (with pharmacokinetic target of 3750 μmol*min/L/day ±10%) for 4 days, higher dose (250 mg/m2) fludarabine and 400 centigray (cGy) of total body irradiation.ProcedureThis retrospective study involved children receiving transplant for acute lymphoblastic leukemia (ALL). It compared children who fell within the target range for busulfan with those who were either not measured or were measured and fell outside this range. All other treatment factors were identical.ResultsTwenty‐nine children (17 within target) were evaluated. All subjects engrafted neutrophils with a median [interquartile range] time of 14 days [8–30 days]. The cumulative incidence of acute graft‐versus‐host disease was 44.8% [95% confidence interval, CI: 35.6%–54.0%], while chronic graft‐versus‐host disease was noted in 16.0% [95% CI: 8.7%–23.3%]. At 2 years, the overall survival was 78.1% [95% CI: 70.8%–86.4%] and event‐free survival was 74.7% [95% CI: 66.4%–83.0%]. Cumulative incidence of relapse was 11.3% [95% CI: 5.1%–17.5%]. There were no statistically significant differences in between the group that received targeted busulfan compared with the untargeted group.ConclusionOur conditioning regiment for children with ALL resulted in outcomes comparable to standard treatment with acceptable toxicities and significant reduction in radiation dose. Targeting busulfan dose in this cohort did not result in improved outcomes.