bluuebunny/crossref_metadata_2025_split huggingface dataset:
De Sal y Arena en escena como análisis del rol de ser mujer
Authors: JIMÉNEZ DRAGUICEVIC PAMELA SOLEDAD , SÁNCHEZ VARGAS ITZEL 
Published: January 2024

Malintzin fue una mujer nahua intérprete y consejera de Hernán Cortés, alrededor de ella, a lo largo de los siglos, se han establecido diferentes análisis y conjeturas, sobre si fue sabia consejera o traidora. Esta mujer significativamente simbólica ¿qué representa para el inconsciente colectivo femenino en México?, una mujer letrada y políglota que no pudo lograr una mayor jerarquía que la de ser acompañante. El Laboratorio Teatral Látex-UAQ realizó una puesta en escena titulada “De Sal y Arena” basada en la conquista la cual buscó reflejar tanto la visión española (los de Sal), como la visión de los pueblos originarios (los de Arena), motivando una reflexión acerca de la riqueza del mestizaje de la que somos herederos. También se destacó como protagonista a Malintzin quien, por su dominio de lenguas y su capacidad para comprender ambas culturas, le permitieron actuar como intermediaria entre los de Sal y los de Arena.
PALABRAS CLAVE: Malintzin, estereotipos, mujer, género, escena.
Universidad y Desarrollo Humano: La Gestión Artística y Cultural desde las Instituciones de Educación Superior
Authors: ALEJANDRO CABRAL PABLO 
Published: January 2024

La gestión cultural desde el ámbito universitario permite un ejercicio de reflexión-praxis-reflexión que obligatoriamente debe abordar diversas dimensiones de la realidad sociocultural. Esto implica atender no sólo a las necesidades institucionales sino también tener un impacto en los diversos sectores de la sociedad dentro del territorio donde la universidad actúa y opera.De esta manera no es otra cosa que atender a las tres funciones sustantivas de las Instituciones de Educación Superior (IES) las cuales son la formación de profesionales, la investigación y el extensionismo.Este trabajo plantea la discusión a través de cuatro apartados: 1 - Pensar la gestión cultural como proceso dialéctico; 2 - Pensar la gestión cultural como proceso de construcción comunitaria; 3 - La gestión cultural desde la universidad; 4 - La Universidad como agente de transformación.Finalmente se presenta el caso práctico del Primer Festival Internacional de Tango UAQ Querétaro 2022, como ejemplo de construcción de un proyecto artístico-cultural de extensionismo universitario.
PALABRAS CLAVE: Gestión Cultural, Universidad, Desarrollo Humano, Extensionismo, Tango.
El tándem Alemania-Francia y la expansión europea hacia el este
Authors: Jaquenod Alejandro Marcelo 
Published: January 2024

Diversos autores plantean la centralidad analítica del tándem europeo Alemania-Francia (también referido como ‘eje francoalemán’) durante el desarrollo de las negociaciones, en contraposición a un tándem Brasil-Argentina por el lado del Mercosur.
El objetivo de este trabajo es problematizar la dinámica de funcionamiento del mencionado tándem en el contexto de expansión de la Unión Europea hacia el este a comienzos del nuevo milenio. Entendemos que las tensiones, alineamientos y realineamientos nacionales durante aquel proceso, al igual que otros sucesos de relevancia que escapan a los objetivos de este trabajo, nos ofrecen material necesario para desplegar y analizar la dinámica de liderazgo europeo entre el tándem mencionado y otros actores relevantes, como el Reino Unido y los órganos institucionales de la Unión.
Comprehensive spatial distribution of patients with first- episode psychosis (FEP) and its relation to socio-economic factors
Authors: Gualda Luz María González , Gonzalez-Rubio Jesus , Najera Alberto , Dies María Aliño , Cremades Rubén Roig , Espuña Javier Bajen , Alarcón Carmen Escobar , Sirvent Noelia Navarro , Lozano María Jesús Montes , Rodríguez Karen Nieto 
Published: January 2024

Abstract

Background:
The functional-cognitive impact of first-episode psychosis (FEP) is extremely relevant and implies dysfunction from early life stages like adolescence and youth. Like other illnesses, FEP incidence is also influenced by environmental factors. It is necessary to attend to this age group with early interventions and to act on the environmental factors that the literature correlates with increased FEP incidence: socio-economic aspects, social adversity, bullying at school or cannabis use. In this context, identifying the areas of cities where FEP patients concentrate is important to perform early interventions. The spatial analysis of patient distribution in a whole city is one way to identify the most vulnerable areas and to propose psycho-social interventions for the possible prevention and/or early detection of FEP by improving urban mental health.
Methods:
An epidemiological study of point patterns to determine the areas of a city with a higher incidence of patients with FEP. To do so, the addresses of FEP cases were georeferenced from 1 January 2016 to 31 October 2022, and 109 FEP patients were analysed. A random sample of 383 controls was recruited from the city census. By GIS, the areas with higher FEP incidence were analysed to see if they coincided with the zones where inhabitants with lower incomes lived.
Results:
The risk ratio of the FEP patients was compatible with the constant risk ratio in Albacete (p = 0.22). When performing the process separately with cases and controls only in men and women, the results were not significant for both distributions (p-value: 0.12 and 0.57, respectively). Nonetheless, areas within the city had a significantly higher risk. These groups of cases coincided with those who had lower income and more inequality for women, but this pattern was not clear for men.
Conclusions:
Classifying city areas per income can help to determine the zones at higher risk of FEP, which would allow early healthcare and preventive measures for these zones.
Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: a Statistical Analysis Plan for the ProMPT-2 randomised controlled trial.
Authors: Smartt Helena Josephine Marie , Angelini Gianni D. , Gibbison Ben , Rogers Chris A. 
Published: January 2024

Abstract
Background
The ProMPT-2 trial (Propofol for Myocardial Protection Trial #2) aims to compare the safety and efficacy of low and high dose propofol supplementation of the cardioplegia solution during adult cardiac surgery versus sham supplementation. This update presents the statistical analysis plan, detailing how the trial data will be analysed and presented. Outlined analyses are in line with the Consolidated Standards of Reporting Trials and the statistical analysis plan has been written prior to database lock and the final analysis of trial data to avoid reporting bias (following recommendations from the International Conference on Harmonisation of Good Clinical Practice).
Methods/design
ProMPT-2 is a multi-centre, blinded, parallel three-group randomised controlled trial aiming to recruit 240 participants from UK cardiac surgery centres to either sham cardioplegia supplementation, low dose (6µg/ml) or high dose (12µg/ml) propofol cardioplegia supplementation. The primary outcome is cardiac-specific troponin T levels (a biomarker of cardiac injury) measured during the first 48h following surgery.
The statistical analysis plan describes the planned analyses of the trial primary and secondary outcomes in detail, including approaches to deal with: missing data, multiple testing, violation of model assumptions, withdrawals from the trial, non-adherence with the treatment and other protocol deviations. It also outlines the planned sensitivity analyses and exploratory analyses to be performed.
Discussion
This manuscript prospectively describes, prior to the completion of data collection and database lock, the analyses to be undertaken for the ProMPT-2 trial to reduce risk of reporting and data-driven analyses.
Trial registration: ISRCTN, ISRCTN15255199. Registered 26th March 2019, https://www.isrctn.com/ISRCTNISRCTN15255199
Harnessing Voice Analysis and Machine Learning for Early Diagnosis of Parkinson's Disease: A Comparative Study Across Three Datasets
Authors: Neto Osmar Pinto 
Published: January 2024

Abstract

Objective: This study evaluates the efficacy of voice analysis combined with machine learning (ML) techniques in enabling early, noninvasive diagnosis of Parkinson's Disease (PD).
Methods: Voice data, phonation of the vowel 'a', from three distinct datasets (two from the UCI ML Repository and one from figshare) for a total of 432 participants (278 PD patients) were analyzed. We employed four ML models - Artificial Neural Networks (ANN), Random Forest (RF), Gradient Boosting (GB), and Support Vector Machine (SVM) - alongside two ensemble methods (soft voting classifier - EVC and stacking method - ESM). The models underwent 50 iterations of evaluation, involving various data splits and 10-fold cross-validation. Comparative analysis was done using one-way ANOVA followed by Bonferroni post-hoc corrections.
Results: The ESM, SVM, and GB models emerged as the top performers, demonstrating superior performance across metrics including accuracy, sensitivity, specificity, precision, F1 score, and ROC AUC. Despite data heterogeneity and variable selection limitations, the models showed high values for all metrics.
Conclusion: Machine learning integration with voice analysis, mainly through ESM, SVM, and GB, is promising for early PD diagnosis. Using multi-source data and a large sample size enhances our findings' validity, reliability, and generalizability.
Significance: This study underscores the potential of noninvasive voice analysis combined with advanced ML to revolutionize early PD detection and pave the way for cost-effective, scalable diagnostic tools.
Impacts of Elderly Population on the Technical Efficiency of Asean
Authors: JEE KOUK HIONG , Rahim Rossazana AB , Khan fatin nur hidayah Taib 
Published: January 2024

Abstract

As labor oriented economies, ASEAN not only consistently suffer a subpar performance in terms of productivity growth compare to other countries in Asia since 1987 but also facing elderly population problem which closely related to Sustainable Development Goals (SDG 8). Hence, this study investigates the impacts of elderly population on the technical efficiency of ASEAN over the period of 1990–2019. The estimated technical efficiency for ASEAN collectively reached 0.7398 with Myanmar in highest and Lao PDR in lowest position. Besides, elderly population was proven negatively and significantly influences the technical efficiency of ASEAN. In depth, 1% increment in elderly population will decrease 3.4% of the estimated technical efficiency of ASEAN. Surprisingly, crude death rate is significantly and positively influences the technical efficiency of ASEAN. It depicted that the growth of population may not able to be transformed as the skilled workers in ASEAN. While labor force participation of the elderly is a current trend in ASEAN, the member states of ASEAN particularly Brunei and Myanmar are suggested to carry out more policies such as providing more ICT skill training and job reallocation based on physical ability to improve the productivity among the elderly labor.
Polymeric IgA with unique glycans protects from necrotoxigenic E. coli O55 infection in an animal model
Authors: Brokesova Diana , Kafkova Leona Raskova , Skarda Jozef , Perutka Zdenek , Sebela Marek , Krupka Michal , Zakostelska Zuzana Jiraskova , Reiss Zuzana , Stepanova Katerina , Srutk Dagmar , Vannucci Luca , Novobilsky Adam , Dvorak Jiri , Kulich Pavel , Stepankova Renata , Tlaskalova-Hogenova Helena , Sinkora Marek , Mestecky Jiri , Raska Milan 
Published: January 2024

Abstract

Antibodies exhibit protective activities through their antigen-specific Fab-dependent interactions and by the Fc-associated glycan moieties.
To evaluate the protective functions of Ig-associated glycans, we compared in vitro and in vivo the human polyclonal secretory (S) IgA with polymeric (p) monoclonal myeloma IgA proteins of defined glycan structure for their protective activity against necrotoxigenic E. coli O55. Namely, we compared the adhesion and penetration of necrotoxigenic E. coli O55 to a pig intestinal IPEC-1 cells and determined the IPEC-1 response relative to the preincubation of bacteria with various pIgA1 or pIgA2. Preparation designated pIgA2(F2) exhibiting unique N-glycan composition and the highest protection in vitro was tested in vivo with respect to the protection against experimental intestine infection of antibody-free newborn piglets by E. coli O55.
pIgA2(F2) reduced inflammatory activation of gut tissue, prevents development of alterations of intestinal architecture including villous blunting and epithelial hyperplasia equally to simultaneously tested milk/colostrum-derived SIgA.
Further studies would lead to the identification of pIgA2 glycans involved in the protection from specific bacterial gut infection.
Work-life balance during the COVID-19 pandemic. A European perspective
Authors: Alfano Vincenzo , Mariotti Ilaria , Nappo Nunzia , Vecchione Gaetano 
Published: January 2024

Abstract

The EU’s remote working landscape, marked by heterogeneity, underwent significant changes due to COVID-19. We use Eurofound’s longitudinal Living, Working and COVID-19 e-survey to explore work-life balance shifts among remote workers from spring 2020 to spring 2022. Quantitative analysis reveals heightened work-life balance challenges for married, female, parent, and university-educated remote workers. Employer work-life balance intensified post-pandemic, while self-employed workers faced consistent challenges. Countries with less of a history of remote work exhibited reduced remote worker satisfaction through all phases of the pandemic. While sectoral effects were not pronounced, this study underscores nuanced demographic and employment-related impacts of remote work on work-life balance. Its findings contribute insights into EU remote work dynamics, offering implications for workforce well-being and management strategies.
JEL Codes J22; J28; J81
Shape of the first mitotic spindles impacts nucleation in human embryos
Authors: Ono Yuki , Shirasawa Hiromitsu , Kazumasa Kazumasa , Goto Mayumi , Ono Takahiro , Sakaguchi Taichi , Okabe Motonari , Hirakawa Takeo , Iwasawa Takuya , Fujishima Akiko , Onodera Yohei , Sugawara Tae , Makino Kenichi , Miura Hiroshi , Fukunaga Noritaka , Asada Yoshimasa , Kumazawa Yukiyo , Terada Yukihiro 
Published: January 2024

Abstract

During human embryonic development, early cleavage-stage embryos are more susceptible to errors. Studies have shown that many problems occur during the first mitosis, such as direct cleavage, chromosome segregation errors, and multinucleation. However, the mechanisms whereby these errors occur during the first mitosis in human embryos remain unknown. To clarify this aspect, in the present study, we imaged discarded living human two-pronuclear stage zygotes using fluorescent labeling and confocal microscopy without microinjection of DNA or mRNA and investigated the association between spindle shape and nuclear abnormality during the first mitosis. We observed that the first mitotic spindles varied, and low-aspect-ratio-shaped spindles tended to lead to the formation of multiple nuclei at the 2-cell stage. Moreover, we observed defocusing poles in many of the first mitotic spindles, which were strongly associated with multinucleation. In addition, it has been suggested that the parental genome remains separated during the first mitosis. Our study will contribute markedly to research on the occurrence of mitotic errors during the early cleavage of human embryos.
A multi-objective train timetable optimization method based on sleep period inspection
Authors: Wang Wenxian , Chen Hao , Zhang Liqing , Jia Li 
Published: January 2024

Abstract
For passengers traveling by the railway, a reasonable train timetable can improve passenger satisfaction efficiently, and improve the service quality of railway passenger transport. Existing related research focuses on reprogramming the train timetable from the perspective of train operating time and operating income, but how to optimize the train timetable from the rationality of passenger travel time has not been greatly resolved. Therefore, this paper proposes a multi-objective train timetable compilation method based on sleep period checking. In this system, the quantitative calculation method of passenger travel time preference is defined, and the passenger arrival time preference function and departure time preference function are fitted by Gaussian function. On this basis, a mixed integer programming model for train timetable optimization is developed. Aiming at this mixed integer nonlinear problem, an improved genetic algorithm based on parallel search mechanism is designed. After the new train timetable is generated, the feasibility of the new train timetable is checked based on the sleep period checking technique. If the new train schedule is feasible, it is indicated as the optimal train schedule. Otherwise, the same algorithm is used again to reschedule. Finally, the performance of the proposed model and algorithm is verified by an example analysis.
Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period.
Authors: Gabaldon-Albero Alba , Martin-Grau Carla , Marti-Masanet Miguel , Lopez-Jimenez Alejandro , Llorens-Salvador Roberto , Beseler-Soto Beatriz , Martin-Zamora Sergio , Lopez Berta , Calvo Inmaculada , Hernandez-Muela Sara , Rosello-Piera Monica , Alonso Carmen Orellana , Castellano Francisco Martinez 
Published: January 2024

Abstract

Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic variants in the ADAR gene and are classified as Aicardi-Goutières Syndrome type 6. Here we present a new homozygous pathogenic variant in the ADAR gene. Currently Janus Kinase inhibitors have been proposed to treat selected interferonopathies such as Aicardi-Goutières Syndrome, although limited information is available on its use and results in the neonatal presentation of this disease.Case presentation We present two siblings, a male neonate with congenital petechial rash, severe thrombopenia and generalized hypotonia and his deceased sister who had normal development until 5 months of age, when she suffered acute encephalopathy. We describe the clinical course, complementary examinations and follow-up with early treatment of the newborn with ruxolitinib. The homozygous variant c.2908G > A (p.Ala970Thr) in the ADAR gene was found in both siblings, parents were heterozygous carriers.Conclusions The homozygous variant c.2908G > A (p.Ala970Thr) in the ADAR gene causes Aicardi-Goutières Syndrome type 6. Intrafamilial phenotypic spectrum of the disease varies among individuals with the same pathogenic variant. Early initiation of ruxolitinib improved systemic signs but did not prevent the progression of neurological disease.
A Multi-Model Assessment of Inequality and Climate Change
Authors: Emmerling Johannes , Andreoni Pietro , Charalampidis Ioannis , Dasgupta Shouro , Dennig Francis , Vandyck Toon , Feindt Simon , Fragkiadakis Dimitris , Fragkos Panagiotis , Fujimori Shinichiro , Gilli Martino , Grottera Carolina , Guivarch Céline , Kornek Ulrike , Kriegler Elmar , Malerba Daniele , Marangoni Giacomo , Méjean Aurélie , Nijsse Femke , Piontek Franziska , Simsek Yeliz , Soergel Bjoern , Taconet Nicolas , Young-Brun Marie , Zheng Yu , Zhao Shiya , Tavoni Massimo 
Published: January 2024

Abstract

Climate change and inequality are critical and interrelated defining issues for this century. Despite growing empirical evidence on the economic incidence of climate policies and impacts, mainstream model-based assessments are often silent on the interplay between climate change and economic inequality. For example, all the major model comparisons reviewed in IPCC neglect within-country inequalities. Here we fill this gap by presenting a model ensemble of eight large-scale Integrated Assessment Models belonging to different model paradigms and featuring economic heterogeneity. We study the distributional implications of Paris-aligned climate target of 1.5 degree and include different carbon revenue redistribution schemes. Moreover, we account for the economic inequalities resulting from residual and avoided climate impacts. We find that price-based climate policies without compensatory measures increase economic inequality in most countries and across models. However, revenue redistribution through equal per-capita transfers can offset this effect, leading to on average decrease in the Gini index by almost two points. When climate benefits are included, inequality is further reduced, but only in the long term. Around mid-century, the combination of dried-up carbon revenues and yet limited climate benefits leads to higher inequality under the Paris target than in the Reference scenario, indicating the need for further policy measures in the medium term.
Dearomative Difunctionalization of Arenes via Highly Selective Radical Relay Reactions
Authors: Zheng Ke , Lei Ning , Zhang Qian , Tao Pan , Lu Cong , Lei Qian 
Published: January 2024

Abstract
Dearomatization of arenes emerges as a reliable strategy for crafting intricate 3D polycyclic frameworks. Nonetheless, the development of an efficient method for dearomatization across diverse arenes remains a formidable challenge, particularly in the case of unactivated benzene. In this study, we present a facile dearomative difunctionalization approach for unactivated arenes through a highly selective radical relay reaction. The reaction operates under mild conditions, devoid of metals, photocatalysts, and additives. This method exhibits a broad substrate scope and exceptional functional group tolerance, successfully transforming various aromatics, including inert naphthalene and benzene rings, indoles, pyrroles, benzofuran, and thiophene. Bioactivity assessments reveal a significant inhibitory effect of the synthesized complex polycyclic frameworks on HCT 116 cancer cells, with subsequent mouse experiments providing compelling evidence of its feasibility.
Adiposity in mares induces insulin dysregulation and mitochondrial dysfunction which can be mitigated by nutritional intervention
Authors: Fresa Kyle J , Catandi Giovana D , Whitcomb Luke A , Gonzalez-Castro Raul A , Chicco Adam J , Carnevale Elaine M 
Published: January 2024

Abstract

Obesity is a complex disease associated with augmented risk of metabolic disorder development and cellular dysfunction in various species. The goal of the present study was to investigate the impacts of obesity on the metabolic health of old mares as well as test the ability of diet supplementation with either a complex blend of nutrients designed to improve equine metabolism and gastrointestinal health or L-carnitine to mitigate negative effects of obesity. Mares (n = 19, 17.9 ± 3.7 years) were placed into one of three group: normal-weight (NW, n = 6), obese (OB, n = 7) or obese fed a complex diet supplement for 12 weeks (OBD, n = 6). After 12 weeks, OB mares received L-carnitine alone for 6 weeks. Obesity in mares was significantly associated with insulin dysregulation, reduced (p < 0.05) muscle mitochondrial function, and decreased (p < 0.05) skeletal muscle oxidative capacity with greater (p < 0.05) ROS production when compared to NW. Obese mares fed the complex diet supplement had better insulin sensivity (p < 0.05), greater (p < 0.05) cell lipid metabolism, and higher (p < 0.05) muscle oxidative capacity with reduced (p < 0.05) ROS production than OB. L-carnitine supplementation alone did not significantly alter insulin signaling, but improved (p < 0.05) lipid metabolism and muscle oxidative capacity with reduced (p < 0.05) ROS. In conclusion, obesity is associated with insulin dysregulation and altered skeletal muscle metabolism in older mares. However, dietary interventions are an effective strategy to improve metabolic status and skeletal muscle mitochondrial function in older mares.