bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors that influence the selection of conservative management for end-stage renal disease – a systematic review
Authors: Sakthivel Pavithra , Mostafa Alyaa , Aiyegbusi Olalekan Lee 
Published: October 2023

Abstract

Background
Most patients with end-stage renal disease (ESRD) are managed with dialysis and less commonly kidney transplantation. However, not all are suitable for or desire either of these renal replacement therapies. Conservative management (CM) is an option. However, the selection of CM is often not easy for patients and clinicians. The aim of this systematic review is to identify the key factors that influence the selection of CM for ESRD.

Methods
Medline, Embase, PsychINFO, and CINAHL Plus were systematically searched from inception to 10 September 2021. Titles/abstracts and full texts were independently screened by two reviewers. Reference lists of included articles were searched. An update search via PubMed was conducted on 10 August 2023. A narrative synthesis of review findings was conducted.

Results
At the end of the screening process, 15 qualitative and 8 survey articles were selected. Reference checking yielded no additional relevant studies. Main themes were: (i) Patient-specific factors; (ii) Clinician-specific factors; (iii) Organisational factors; and (iv) National and international factors. Patient-specific factors were awareness and perceptions of CM and dialysis, beliefs about survival, preferred treatment outcomes and influence of family/caregivers and clinicians. Clinician-specific factors included perceptions of CM as ‘non-intervention’, perceptions of clinician role in the decision-making process, and confidence and ability to initiate sensitive treatment discussions. Relationships with and involvement of other healthcare professionals, time constraints, and limited clinical guidance were also important factors.

Conclusions
An improvement in the provision of education regarding CM for patients, caregivers, and clinicians is essential. Robust studies are required to generate crucial evidence for the development of stronger recommendations and guidance for clinicians.
Impact of hypertriglyceridaemia on cardiovascular mortality according to low-density lipoprotein cholesterol in a 15.6-million population
Authors: Park Hyung-Bok , Arsanjani Reza , Hong Sung-Jin , Yi Jee-Jeon , Yi Sang-Wook 
Published: October 2023

Abstract

Aims
The aim of this study was to assess the association between triglyceride (TG) levels and cardiovascular disease (CVD) mortality concerning low-density lipoprotein cholesterol (LDL-C) and age in the general population.

Methods and results
From the Korean National Health Insurance Service database, 15 672 028 participants aged 18–99 who underwent routine health examinations were followed up for CVD mortality. Hazard ratios for CVD mortality were calculated using Cox models after adjusting for various confounders. During a mean of 8.8 years of follow-up, 105 174 individuals died of CVD. There was a clear log-linear association between TG and overall CVD mortality down to 50 mg/dL. Each two-fold increase in TG was associated with 1.10-fold (overall CVD), 1.22-fold [ischaemic heart disease (IHD)], 1.24-fold [acute myocardial infarction (AMI)], and 1.10-fold (ischaemic stroke) higher CVD mortality. Haemorrhagic stroke and heart failure were not associated with TG levels. The impact of hypertriglyceridaemia (HTG) on CVD weakened but remained present in persons with LDL-C &lt; 100 mg/dL, in whom each two-fold higher TG was associated with 1.05-fold (overall CVD), 1.12-fold (IHD), 1.15-fold (AMI), and 1.05-fold (ischaemic stroke) higher CVD mortality. The younger population (18–44 years) had stronger associations between TG levels and mortality from overall CVD, IHD, and AMI than the older population.

Conclusion
Hypertriglyceridaemia independently raises CVD mortality with lingering risks in young and older individuals with low LDL-C levels, suggesting the importance of management of HTG even with controlled LDL-C.
The crustal structure of the western Amundsen Basin, Arctic Ocean, derived from seismic refraction/wide-angle reflection data
Authors: Castro Carlos F , Funck Thomas , Hopper John R 
Published: October 2023

SUMMARY
Two geophysical expeditions (LOMROG II and III) were carried out in 2009 and 2012 to acquire seismic data in the western Amundsen Basin in the Arctic Ocean, a basin formed by ultraslow seafloor spreading at the Gakkel Ridge. Previous studies show alternating magmatic and amagmatic segments at the ridge but it is unclear if such segmentation persisted throughout the entire opening history of the basin. The seismic refraction data were used to develop P-wave velocity models down to the uppermost mantle using forward modelling of traveltimes. The coincident seismic reflection data were used to constrain the geometry of the sedimentary layers and for characterizing the acoustic basement. 2-D gravity modelling was used to determine the Moho depth in areas when data quality was insufficient to resolve a Moho reflection. The models distinguish three different basement types: oceanic crust with layers 2 and 3, oceanic crust that is lacking a layer 3 and exhumed and serpentinized mantle. The maximum observed crustal thickness is 6 km. Areas with thin crust (&lt;3 km) may be underlain by partially serpentinized mantle. Where exhumed mantle is observed, a serpentinization front separates highly serpentinized mantle at the top from partially serpentinized mantle below. The presence of oceanic crust off-axis of the presently amagmatic sector of the Gakkel Ridge indicates that there is both a spatial and temporal variation of crustal accretion processes at the ridge.
Bayesian estimation of non-linear centroid moment tensors using multiple seismic data sets
Authors: Hamidbeygi Mahdi , Vasyura-Bathke Hannes , Dettmer Jan , Eaton David W , Dosso Stan E 
Published: October 2023

SUMMARY
Centroid moment tensor (CMT) parameters of earthquakes are routinely estimated to gain information on structures and regional tectonics. However, for small earthquakes (M &lt; 4), it is still challenging to determine CMTs due to the lack of high-quality waveform data. In this study, we propose to improve solutions for small earthquakes by incorporating multiple seismic data types in Bayesian joint inversion: polarities picked on broad-band signals, amplitude spectra for intermediate frequency bands (0.2–2.0 Hz), and waveforms at low frequencies (0.05–0.2 Hz). Both measurement and theory errors are accounted for by iterative estimation of non-Toeplitz covariance matrices, providing objective weightings for the different data types in the joint parameter estimation. Validity and applicability of the method are demonstrated using simulated and field data. Results demonstrate that combinations of data, such as a single high-quality waveform, a few amplitude spectra and many waveform polarities, are able to resolve CMT parameters to comparable quality as if many high-quality waveforms were available. Results of 10 induced seismic events that occurred in northeastern British Columbia, Canada, between January 2020 and February 2022 indicate predominantly strike-slip focal mechanisms with low non-double-couple components. These events appear to be located at shallow depths with short time duration, as expected for induced seismicity. These results are consistent with previous studies, indicating that this method reduces the dependence of source inversion on high-quality waveforms, and can provide resolution of CMT parameters for earthquakes as small as ML 1.6.
Funnel control of linear systems with arbitrary relative degree under output measurement losses
Authors: Berger Thomas , Lanza Lukas 
Published: October 2023

Abstract
We consider tracking control of linear minimum phase systems with known arbitrary relative degree which are subject to possible output measurement losses. We provide a control law which guarantees the evolution of the tracking error within a (shifted) prescribed performance funnel whenever the output signal is available. The result requires a maximal duration of measurement losses and a minimal time of measurement availability, which both strongly depend on the internal dynamics of the system, and are derived explicitly. The controller is illustrated by a simulation of a mass-on-car system.
The Arenaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens
Authors: Hastie Kathryn M , Melnik Lilia I , Cross Robert W , Klitting Raphaëlle M , Andersen Kristian G , Saphire Erica Ollmann , Garry Robert F 
Published: October 2023

Abstract
Lassa virus (LASV), Junin virus (JUNV), and several other members of the Arenaviridae family are capable of zoonotic transfer to humans and induction of severe viral hemorrhagic fevers. Despite the importance of arenaviruses as potential pandemic pathogens, numerous gaps exist in scientific knowledge pertaining to this diverse family, including gaps in understanding replication, immunosuppression, receptor usage, and elicitation of neutralizing antibody responses, that in turn complicates development of medical countermeasures. A further challenge to the development of medical countermeasures for arenaviruses is the requirement for use of animal models at high levels of biocontainment, where each model has distinct advantages and limitations depending on, availability of space, animals species-specific reagents, and most importantly the ability of the model to faithfully recapitulate human disease. Designation of LASV and JUNV as prototype pathogens can facilitate progress in addressing the public health challenges posed by members of this important virus family.
Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses
Authors: Powers Ann M , Williamson Lauren E , Carnahan Robert H , Crowe James E , Hyde Jennifer L , Jonsson Colleen B , Nasar Farooq , Weaver Scott C 
Published: October 2023

Abstract
The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human pathogens with the potential to spread to near pandemic proportions. Most of these are zoonotic, with spillover infections of humans and domestic animals, but a few such as chikungunya virus (CHIKV) have the ability to use humans as amplification hosts for transmission in urban settings and explosive outbreaks. Most alphaviruses cause nonspecific acute febrile illness, with pathogenesis sometimes leading to either encephalitis or arthralgic manifestations with severe and chronic morbidity and occasional mortality. The development of countermeasures, especially against CHIKV and Venezuelan equine encephalitis virus that are major threats, has included vaccines and antibody-based therapeutics that are likely to also be successful for rapid responses with other members of the family. However, further work with these prototypes and other alphavirus pathogens should target better understanding of human tropism and pathogenesis, more comprehensive identification of cellular receptors and entry, and better understanding of structural mechanisms of neutralization.
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures
Authors: Kuhn Richard J , Barrett Alan D T , Desilva Aravinda M , Harris Eva , Kramer Laura D , Montgomery Ruth R , Pierson Theodore C , Sette Alessandro , Diamond Michael S 
Published: October 2023

Abstract
Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective. While vaccines against some medically important flaviviruses are available, others have proven challenging to develop. The emergence and spread of flaviviruses, including dengue virus and Zika virus, demonstrate their pandemic potential. This review highlights the gaps in knowledge that need to be addressed to allow for the rapid development of vaccines against emerging flaviviruses in the future.
Chinese Foreign Real Estate Investment and Local Voting in US Presidential Elections
Authors: Liao Steven 
Published: October 2023

Abstract
Despite the increasing globalization of housing markets, little is known about its political implications. This study investigates whether rising Chinese investments in US homes influenced local voting in recent US presidential elections. Building on pocketbook/sociotropic voting and nativism theories, I develop hypotheses on the electoral consequences of foreign real estate investment through greater home demand and equity, improved local economies, and changing neighborhoods. Using difference-in-differences designs that combine a unique shock to Chinese capital outflows in 2013 with county-level measures of local attractiveness to Chinese investments, I find that greater exposure reduced Democratic vote shares in both the 2016 and 2020 presidential elections. Furthermore, an initially larger white population strengthened this effect, while a larger college-educated population weakened it. In contrast, local equity gains, housing competition, or economic strength did not systematically influence the effect. Together, the results appear more consistent with the pro-conservative effects of nativism.
R&D location in dynamic industry environments
Authors: Colombo Luca , Dawid Herbert , Harting Philipp 
Published: October 2023

Abstract
We study firms’ optimal R&D location strategies in a dynamic industry model with competition in product quality. In light of potential future inwards and outwards spillovers firms make their location choices relying on heuristic strategies that are based on the expected present values associated with alternative location patterns. Using a simulation analysis, we show how the strategies of innovators and imitators differ and how they depend on whether firms operate in strongly or weakly innovative industry environments. We also characterize how firms’ location choices should account for the innovativeness of the competitors active in a location.
Black cancer patients navigating a health-care system of racial discrimination
Authors: Garrett Elleyse , Ma Cindy , Ochoa-Dominguez Carol Y , Navarro Stephanie , Yoon Paul , Hughes Halbert Chanita , Farias Albert J 
Published: October 2023

Abstract

Background
Exposure to racial discrimination may exacerbate disparities throughout the cancer care continuum. Therefore, we explored how experiences of racial discrimination in the health-care setting manifest for Black cancer patients and how it contributes to racial disparities in cancer care.

Methods
This qualitative analysis used semistructured in-depth interviews with Black cancer survivors not on active treatment from May 2019 to March 2020. All interviews were audio recorded, professionally transcribed, and uploaded into Dedoose software for analysis. We identified major themes and subthemes that highlight exposure to racial discrimination and its consequences for Black cancer patients when receiving cancer care.

Results
Participants included 18 Black cancer survivors, aged 29-88 years. Most patients experienced racial discrimination when seeking care. Participants experienced racial discrimination from their interactions with health-care staff, medical assistants, front desk staff, and health insurance administrators. Exposure to overt racial discrimination in the health-care setting was rooted in racial stereotypes and manifested through verbal insults such as physicians using phrases such as “you people.” These experiences impacted the ability of the health-care delivery system to demonstrate trustworthiness. Patients noted “walking out” of their visit and not having their health issues addressed. Despite experiences with racial discrimination, patients still sought care out of necessity believing it was an inevitable part of the Black individual experience.

Conclusion
We identified that exposure to racial discrimination in the health-care setting is pervasive, affects health-seeking behaviors, and degrades the patient–clinician relationship, which may likely contribute to racial disparities in cancer care.
Appendicitis mimicry of dolichocolon
Authors: Brown Kayla K , Jolley Mercedes C , Kocay Dean A 
Published: October 2023

Abstract
Dolichocolon is an under-reported, under-diagnosed etiology of chronic constipation that is often overlooked as being a primary diagnosis. We present a case of an undiagnosed dolichocolon in a young adult female whose initial presentation was concerning of appendicitis. Eventually, the patient underwent a subtotal colectomy as a definitive treatment for chronic constipation. Dolichocolon is an anatomical variant that can have severe lifelong consequences, such as chronic constipation, which greatly affects a patient’s quality of life and overall health if undiagnosed. The purpose of this case report is to raise awareness among the surgical community regarding the significance of early dolichocolon diagnosis, prevent misdiagnosis, and ultimately improve patient outcomes, including reducing complications associated with chronic constipation.
Bouveret syndrome: two approaches one stone
Authors: Satchithanandha Vysheki , Lau Ngee-Soon , Galevska Ana , Sandroussi Charbel 
Published: October 2023

Abstract
Bouveret syndrome is a rare cause of gastric outlet obstruction, a consequence of a large impacted gallstone leading to the formation of a bilioenteric fistula. We present a case of a 79-year-old female who presented with a history of persistent nausea and vomiting. Computed tomography of the abdomen revealed a large gallstone impacted in the second part of the duodenum, complicated by a cholecystoduodenal fistula, leading to gastric outlet obstruction. After nasogastric decompression, the patient underwent an upper gastrointestinal endoscopy and attempted stone retrieval which was unsuccessful. Consequently, she underwent laparotomy, gastrotomy, and extraction of the stone. This case highlights the pitfalls of managing Bouveret syndrome via an endoscopic or an open surgical approach.
Adult intussusception of the small intestine caused by cystic fibrosis: a case report, review of the literature, and guide for management
Authors: Adu Yaw , Wolkober Brianna , Nesiama Esere , Thompson Lori , Laswi Mujahed , Obokhare Izi 
Published: October 2023

Abstract
Intussusception, an uncommon but potentially severe condition primarily associated with infants and young children, can also present in adults, posing distinct challenges in diagnosis and treatment. This report presents the case of a 22-year-old male with cystic fibrosis, who developed intussusception due to severe constipation in his distal gastrointestinal tract. The patient’s initial presentation included abdominal pain, constipation, and abnormal laboratory results. Computed tomography scans revealed intussusception affecting the ascending colon and cecum, necessitating surgical intervention and subsequent bowel resection. In adults, the presence of intussusception often triggers suspicion of underlying pathological lead points. However, in this instance, the root cause was attributed to cystic fibrosis induced constipation. Current evidence suggests limited efficacy with conservative treatment, with bowel resection being the most definitive treatment option. Further research is warranted to establish comprehensive guidelines for managing this uncommon condition, particularly when intertwined with cystic fibrosis.
Facial kinship verification and searching for genetic origins in gamete/embryo donor conception—an overview of potential legal and ethical issues
Authors: Łukasiewicz Rafał , Frith Lucy , Redhead Caroline 
Published: October 2023

Abstract
The aim of Facial Kinship Verification (FKV) technologies is to determine, by comparing images of their faces, whether two people are related genetically. FKV is developing rapidly, and it could be used to search for genetic relatives in a variety of ways and settings, such as searching for missing children or unknown parents. In this article, we focus on one area where this technology might have significant implications, the searching for gamete (egg and sperm) and embryo donor(s) by donor-conceived people. In many jurisdictions, donor-conceived people do not have access to information about their donor’s identity, and laws differ significantly in this area. We offer an initial overview of the legal and related ethical issues raised by FKV in this context, and touch on other areas where it might be used to find genetic relatives, as a starting point for further analysis and research.
In Situ Transmission Electron Microscopy Study of Bubble Behavior Near the Surface of Ice Crystals by Using a Liquid Cell With a Peltier Cooling Holder
Authors: Yamazaki Tomoya , Yashima Yuga , Katsuno Hiroyasu , Miyazaki Hiroya , Gondo Takashi , Kimura Yuki 
Published: October 2023

Abstract
Liquid cell transmission electron microscopy (LC-TEM) is a unique technique that permits in situ observations of various phenomena in liquids with high spatial and temporal resolutions. One difficulty with this technique is the control of the environmental conditions in the observation area. Control of the temperature ranging from room temperature to minus several tens of degrees Celsius, is desirable for controlling the supersaturation in various materials and for observing crystallization more easily. We have developed a cooling transmission electron microscopy specimen holder that uses Peltier devices, and we have combined it with a liquid cell to realize accurate temperature control in LC-TEM. We evaluated this system by using water as a specimen. Motionless bubbles, shown to be voids containing pressurized gas, formed in the specimen sometime after the temperature had reached −12°C. An electron diffraction pattern showed that the specimen turned into ice Ih after the formation of these bubbles, confirming that our system works properly and can induce crystallization. In addition, we analyzed the behavior of bubbles formed in the ice Ih, and we discussed the formation of these bubbles and their internal pressure.