bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study Protocol of the Planetary Health Action Survey PACE – A serial cross-sectional survey to assess the general population’s readiness to act against the climate crisis in Germany
Authors: Lehrer Lena , Geiger Mattis , Sprengholz Philipp , Jenny Mirjam A. , Temme Hellen L. , Shamsrizi Parichehr , Eitze Sarah , Betsch Cornelia 
Published: February 2024

Abstract
Background
Climate change is a paramount global health threat with multifaceted health implications. Societal change is required to mitigate the negative effects of climate change, as well as help people adapt to the associated health risks. This requires situation-specific, large-scale data that can help identify the relevant areas for policymaking and communication. Such behavioral data can help scientists and policymakers understand public perceptions and behaviors, as well as identify the levers to increase public readiness to act (RTA) against climate change and protect their health. The Planetary Health Action Survey (PACE) explores RTA, integrating individual behavior, policy acceptance, and political participation as its key indicators and determinants. The ongoing survey seeks to develop and refine an integrated conceptual model of RTA, create valid corresponding measurement instruments, and implement them in monitoring. This contribution serves as the study protocol for PACE.
Methods
In continuous cross-sectional data collections, a comprehensive set of sociocognitive factors, including climate change knowledge, trust in institutions, perceived health risks, self-efficacy, social norms, and perceived effectiveness of policy measures, are assessed. The online questionnaire is updated regularly and involves a nonprobabilistic quota sample from the German population (N ≈ 1,000 at each data collection).
Discussion
PACE contributes to a comprehensive understanding of tackling climate change and related health risks by considering the different facets relevant to societal change. In addition, it allows for observing changes over time and adjustments to the model, as well as including current topics and debates. It provides a broad foundation for future health and crisis communication. PACE contributes to informing climate change and health communication, policymaking, and interventions by providing insights into the multidimensional factors influencing RTA against climate change.
Long-Term Motor Training Enhances Functional Connectivity between Semantic and Motor Regions in an Effector-Specific Manner: Evidence from Elite Female Football Athletes
Authors: Zhou Qingcan , Chen Yanzhang , Zhou Chenglin , Wang Jian 
Published: February 2024

Abstract

The relation between the action verb semantic processing and sensorimotor experience remains controversial. In this study, we examined whether plasticity changes in brain are specifically related to semantic processing of foot action verbs when long-term motor training is mainly aimed at the foot. To address this question, we acquired resting-state functional magnetic resonance imaging scans and behavioral data from a verb two-choice task from female expertise football players and football novices. We compared the resting-state functional connectivity (rsFC) differences between experts and novices using motor execution regions and general semantic regions (left anterior temporal lobe, lATL) as seed, and explored the neural correlates of behavioral performance. Here, the drift rate (v) parameter of the Drift Diffusion Model (DDM) was used to capture the semantic processing capability. We found experts showed increased correlation between lATL subregions and important brain regions for motor processing, including supplementary motor area (SMA), bilateral paracentral lobule (PL), superior parietal lobule (SPL) and inferior parietal lobule (IPL), in contrast to novices. Further predictive model analysis showed the FC found in rsFC analysis can significantly predict drift rate of foot action verb in both experts and novices, but not drift rate of hand action verb. Our findings therefore establish a connection between effector-related semantic processing and the plasticity changes in brain functional connectivity, attributable to long-term foot-related motor training. This provides evidence supporting the view that semantic processing is fundamentally rooted in the sensorimotor system.
National Study Reveals Gram Negative Bacteremia on Contemporary Pediatric AML Protocol
Authors: Arad-Cohen Nira , Messinger Yoav , Barzilai-Birenboim Shlomit , Ben-Harosh Miriam , Golan-Malki Michal , Rosenfeld-Kaidar Hila , Weinreb Sigal , Shachor-Meyouhas Yael , Dabaja-Younis Halima 
Published: February 2024

Abstract
Background
Bacteremia complicates more than 50% of childhood Acute myeloid leukemia (AML) patients with predominantly Gram-positive cocci )GPC).
Objectives
Assess bacteremia rates, risk factors, causative organisms, and antibiotic resistance in Israeli children with de-novo AML.
Methods
all chemotherapy courses for patients enrolled in the standard arm of the NOPHO-DBH 2012 AML protocol were included. Down syndrome, myelodysplastic syndrome, acute promyelocytic leukemia, secondary AML, and isolated granulocytic sarcoma were excluded. No routine antibacterial prophylaxis was applied.
Results
Among 69 patients, 7 had focal bacterial infections. Of the remaining 62, 77.4% had bacteremia episodes, ranging from 1 to 8 per patient. Out of 238 chemotherapy courses, 98 (41.2%) resulted in bacteremia, with 66 (67.3%) courses showing predominantly Gram-negative rods (GNR) and 28 (28.6%) courses with Gram-positive cocci (GPC). The most common was Escherichia coli; followed by Klebsiella spp. Older age, Arab ethnicity, and presenting white blood cell count were associated with an increased risk of bacteremia in a univariate analysis. Six patients (9.7%) died, 3 of whom were from Gram-negative infection. Bacteremia resulted in a 7-fold increase in intensive care unit admissions. Empiric antibiotic treatment using piperacillin-tazobactam and vancomycin provided sufficient coverage in 75.5% of cases. Improved coverage was attained with amikacin (90.8%) or the combination of vancomycin and meropenem (94.7%). Quinolones were effective against GNR isolates in 42 cases (61.8%).
Conclusions
De-novo AML patients face high mortality from predominantly GNR bacteremia. Specific interventions are needed to reduce rates, but limited susceptibility to quinolones hampers prophylactic use.
How can advocates leverage power to advance comprehensive regulation on ultra- processed foods? Learning from advocate experience in Argentina
Authors: Wahnschafft Simone , Spiller Achim , Graciano Andrea 
Published: February 2024

Abstract

Background.
The use of corporate power to undermine public health policy processes is increasingly well understood; however, relatively little scholarship examines how advocates can leverage power to promote successful health policy decisions. The objective of this paper is to explore how advocates leveraged three forms of power – structural, instrumental and discursive – to promote the successful passage of the Promotion of Healthy Eating Law (Ley 27,642) in Argentina, one of the most comprehensive policies to introduce mandatory front-of-package (FOP) warning labels and regulate the marketing and sales of ultra-processed foods (UPFs) adopted to date.
Methods.
We conducted seventeen semi-structured interviews with advocates from different sectors, including civil society, international agencies, and government. Both data collection and analysis were guided by Milsom’s conceptual framework for analyzing power in public health policymaking, and the data was analyzed using hybrid deductive and inductive thematic analysis.
Results.
Advocates harnessed structural power through informal networks and formal coalitions, enabling them to convene discussion spaces with decision-makers, make strategic use of limited resources, and cultivate the diverse expertise (e.g., research, nutrition science, advocacy, law, political science, activism and communications) needed to support the law through different phases of the policy process. Advocates wielded instrumental power through amassing an armada of localized evidence to promote robust policy design, conducting targeted advocacy, and exposing conflicts of interest to harness public pressure. Adopting a rights-based discourse, including of children and adolescents and of consumers to transparent information, enabled advocates to foster a favorable perception of the law amongst both decision-makers and the public. Key contextual enablers of success include a political window of opportunity, the COVID-19 pandemic, securing of international funding for advocacy purposes, and the ability to learn from the regional precedent of similar policies.
Conclusions.
Public health policymaking, particularly when encroaching upon corporate interests, is characterized by stark imbalances of power that hinder successful policy decisions. The strategies identified in the case of Argentina provide important insights as to how advocates might harness and exercise structural, instrumental, and discursive power to counter corporate influence and promote the successful adoption of comprehensive UPF regulation.
Reproductive agency and the value of reproductive choice among migrants from the Middle East and North Africa and Sub-Saharan Africa living in Sweden–a cross-sectional analysis of the Migrants World Values Survey
Authors: Kop Mia van der , Båge Karin , Tirado Veronika , Kågesten Anna , Puranen Bi , Sorcher Rachael , Ekström Anna Mia , Larsson Elin C. 
Published: February 2024

Abstract
Background Sweden has a longstanding history of promoting sexual reproductive health and rights. Reproductive decision-making is a fundamental right, but an individual’s decision-making power differs across contexts. We examined self-reported reproductive agency and the value individuals place on reproductive choice among migrants in Sweden originating from the Middle East or North Africa (MENA) and Sub-Saharan Africa (SSA).Methods This cross-sectional study used face-to-face interview data from the 2018–2019 Migrant World Values Survey (MWVS) and included individuals 18–49 years old who migrated to Sweden from MENA or SSA. Partial proportional odds models were used to estimate adjusted odds ratios (aOR) and corresponding confidence intervals (CI) of associations between sociodemographic factors and two outcomes: 1) reproductive agency (decision-making power on when, with whom, and how many children to have), measured on a 10-point scale categorized as low (1–4), moderate (5–7), and high (8–10); and 2) the value of reproductive choice, measured by the WVS choice index comprising the justifiability of divorce, abortion, and homosexuality, categorized as 0-<0.4 (low), 0.4-<0.7 (moderate), and 0.7-1.0 (high).Results Between September 2018 and November 2019, 7991 participants responded to the MWVS, of whom 4669 met the inclusion criteria. Less than five per cent of respondents placed a high value on reproductive choice, whereas 73% expressed a high degree of reproductive agency. Living in Sweden ≥ 4 years was associated with a high value of reproductive choice (aOR 1.76, 95% CI 1.15–2.67), but not with reproductive agency. Identifying as Muslim was associated with a lower likelihood of valuing choice (aOR 0.44, 95% CI 0.32–0.63) but was not associated with reproductive agency (aOR 1.40, 95% CI 0.87–2.24). Neither age nor reason for migration (family reunification or as a refugee) were associated with either outcome.Conclusion Our study found that migrants from MENA and SSA expressed a high degree of reproductive agency. Migrants placed a low value on reproductive choice; however, this increased with time spent in Sweden. Understanding factors associated with migrants’ sense of reproductive agency and their values and how these change over time in Sweden provides a foundation for working towards equitable sexual and reproductive health and rights.
AMMI and GGE-biplot Analysis of the Yield Performance and Stability of Medium-Mature Soybean [Glycine max (L.) Merrill] Genotyped Plants in Southern and Northwestern Ethiopia
Authors: Amogne Asmamaw 
Published: February 2024

Abstract
The aim of this research was to examine the genotype‒environment relationship for soybean genotype yield by employing AMMI and GGE biplot analysis and to identify stable genotypes in southwestern Ethiopia. Twenty-three recently introduced soybean genotypes, including two controls, were tested during two seasons, in 2020 and 2021, at four separate test sites. A simple lattice design was used to set up the experiment. Using additive main effects and multiplicative interactions (AMMIs) and genotype main effects and a genotype × environment interaction (GGE), the adaptability and stability of the soybean genotypes were examined. Significant (p < 0.01) genotype, environmental, and genotype × environment interaction effects were found through AMMI analysis. According to the analysis of variance, 56.9% of the soybean yield was explained by the environment, 6.3% by genotype differences, and 36.7% by the GE interaction. The overall yield variability of the soybean genotypes exhibited considerable variation in the first four PCAs. The 10 (Tgx-2010-3F), 16 (Tgx-2007-11F), and 17 (TgX-2007-8F) genotypes were suggested for these particular tested environments because they were adaptive to the PW200, PW21, and AR20 environments according to the AMMI and GGE results. However, the 22 (Tgx-1989-19F) and 5 (Tgx-1987-10F) genotypes were found to be relatively stable and adaptable.
AMMI and GGE-biplot Analysis of the Yield Performanceand Stability of Medium-Mature Soybean [Glycine max (L.) Merrill] Genotyped Plantsin Southern and Northwestern Ethiopia
Authors: Amogne Asmamaw , Malede Molla , Tefera Gezahegn 
Published: February 2024

Abstract
The aim of this research was to examine the genotype‒environmentrelationship for soybean genotype yield by employing AMMI and GGE biplot analysis and to identifystable genotypes in southwesternEthiopia. Twenty-three recently introduced soybean genotypes, including two controls, were tested during two seasons, in 2020 and 2021,at four separate test sites. A simple lattice design was used to set up the experiment. Using additive main effects and multiplicative interactions (AMMIs)and genotype main effects and a genotype ×environment interaction (GGE), the adaptability and stability of the soybean genotypes were examined. Significant (p<0.01) genotype, environmental, and genotype × environment interaction effects were found through AMMI analysis. According to theanalysis of variance, 56.9% of the soybean yield was explained by the environment, 6.3% by genotype differences, and 36.7% by the GE interaction. The overall yield variability of the soybean genotypes exhibited considerable variation in the first four PCAs. The 10 (Tgx-2010-3F), 16 (Tgx-2007-11F), and 17 (TgX-2007-8F) genotypes were suggested for these particular tested environments because they were adaptive to thePW200, PW21, and AR20 environmentsaccording to the AMMI and GGE results. However, the 22 (Tgx-1989-19F) and 5 (Tgx-1987-10F) genotypes were found to be relatively stable and adaptable.
Dynamics of cardiomyocyte gene expression and reversibility of catecholamine-induced heart injury
Authors: Bode Christine , Preissl Sebastian , Hein Lutz , Lother Achim 
Published: February 2024

Abstract
Introduction
Catecholamines such as adrenaline and noradrenaline are key regulators of cardiac function in response to increased demand due to stress, illness, or injury, and are used as therapeutic drugs in intensive care medicine. Continuous overactivation of adrenergic receptors, e.g. in heart failure, clearly aggravates detrimental cardiac remodeling, however, whether transient adrenergic stimulation causes persistent myocardial injury remains debated. In this study, we asked whether the structural alterations of the heart induced by adrenergic stimulation are reversible and investigated the molecular mechanisms involved in the remodeling and reverse remodeling process.
Methods and results
Wild-type mice were assigned to 14 days treatment with isoprenaline and phenylephrine (IsoPE), treatment with IsoPE and subsequent recovery, or healthy control groups. IsoPE induced substantial cardiac fibrosis and hypertrophy without signs of functional impairment during echocardiography. RNA sequencing from cardiomyocyte nuclei isolated by flow cytometry revealed marked changes in gene expression after IsoPE treatment (295 differentially expressed genes) related to transforming growth factor signaling, vasculature development, or extracellular matrix organization. Analysis of enhancer regions that were linked to differentially expressed genes identified AP-1 family members Jun and Fos as key drivers of these processes and predicted their direct target genes in cardiomyocytes. IsoPE induced marked changes in the gene expression of adrenergic receptors and their downstream signaling pathways in cardiomyocytes that may be related to receptor desensitization. Within two weeks after IsoPE withdrawal, structural remodeling of the heart recovered and ~95 % of genes that were differentially expressed with IsoPE treatment returned to baseline expression.
Conclusion
We demonstrate here that prolonged catecholamine treatment at doses that induce left ventricular hypercontractility, but no overt heart failure, resulted in significant yet reversible cardiac injury. Immediate early transcription factors such as Jun and Fos were identified as main drivers of IsoPE induced pathological gene expression in cardiomyocytes.
Long-term symptoms after SARS-CoV-2 infection in a cohort of people living with HIV (PLWH): a real-life study
Authors: Antoni Melania Degli , Maifredi Giovanni , Storti Samuele , Tiecco Giorgio , Gregorio Marco Di , Rossi Benedetta , Gasparotti Cinzia , Focà Emanuele , Castelli Francesco , Quiros-Roldan Eugenia 
Published: February 2024

Abstract

Background
Our Hospital in Northern Italy assists 3817 people living with HIV (PLWH) and has faced the impact of COVID-19. Little is known about the impact of HIV infection on the risk of post-COVID-19 conditions (PCCs) onset. We aim to assess the incidence of PCC in PLWH and the factors associated with its occurrence.
Methods
We performed a retrospective, observational study including all PLWH > 18 years registered in the Brescia Health Protection Agency database, assessing SARS-CoV-2 burden, vaccination status, socio-demographic, and viro-immunological parameters from February 2020 until May 2022. Persistence of self-reported symptoms (clustered into gastrointestinal, respiratory, osteo-muscular, and neuro-behavioral symptoms) was evaluated after 3 months by a telephone-administered questionnaire. We estimated the associations between all variables and outcomes through univariate and multivariable logistic models.
Results
In the study period, 653 PLWH were diagnosed with SARS-CoV-2 infection (17.1%). We observed 19 (2.9%) reinfections, 71 (10.9%) hospitalizations, and 3 (0.5%) deaths. We interviewed 510/653 PLWH (78%), and 178 (PCCs prevalence 34.9%; CI95% 30.7–39.2) reported persistent symptoms. Asthenia/fatigue was the most reported symptom (60/178), followed by muscular pain (54/178). In the multivariate regression model, male sex was protective (adjusted OR = 0.64; CI95% 0.99–3.66), while hospitalization during acute infection was associated with an increased the risk of PCCs (adjusted OR = 1.9; CI95% 0.99–3.66). Notably, no viro-immunological variable modified the PCCs risk onset.
Conclusions
Our study highlights a substantial prevalence of PCCs among PLWH, three months post-SARS-CoV-2 infection, independent of viro-immunological features or vaccination status.
Trends in Cervical Cancer Incidence and Mortality in the United States, 1975-2018. A Population-Based Study
Authors: Cheng Xianying , Wang Ping , Cheng Li , Zhao Feng , Liu Jiangang 
Published: February 2024

Abstract
Background: Cervical cancer incidence and mortality have declined substantially in the U.S. over many years, largely due to the decline in squamous cell carcinoma. However, the trend change in recent years is not clear. This study aimed to explore trends in cervical cancer incidence and mortality stratified by demographic and tumor characteristics during 1975-2018.
Methods: Cervical cancer age-adjusted incidence, incidence-based mortality, and relative survival were calculated using the Surveillance, Epidemiology, and End Results-9 database. Trends and the calculation of annual percent change (APC) and average annual percent change (AAPC) were realized by joinpoint software.
Results: A total of 49,658 cases were diagnosed with cervical cancer between 1975-2018 and 17,099 patients died between 1995-2018. Among them, squamous cell carcinoma was the most common histological type (34,169 cases and 11,859 deaths). Cervical cancer incidence rate declined by an average of 1.9% (95% CI, -2.3% to -1.6%) per year over the study period, with the APCs decreased in recent years (-0.5% [95% CI, -1.1% to 0.1%] in 2006-2018). The incidence trend of squamous cell carcinoma was basically consistent with that of the general population, but the incidence of squamous cell carcinoma in distant stage was increasing significantly (1.1% [95% CI, 0.4% to 1.8%] in 1990-2018). During 1995-2018, cervical cancer mortality rate decreased by 1.0% (95% CI, -1.2% to -0.8%) per year overall, but increased by 1.2% (95% CI, 0.3% to 2.1%) per year for distant stage squamous cell carcinoma.
Conclusion: For cases diagnosed with cervical cancer in the United States from 1975 to 2018, the overall incidence and mortality rates decreased significantly, with increase in the incidence and mortality of advanced-stage squamous cell carcinoma. These findings will provide a scientific basis for cervical cancer prevention and management.
Proteomic response of Tartary buckwheat under mercury-induced stress
Authors: Pirzadah Tanveer Bilal , Malik Bisma , Rehman Reiaz Ul 
Published: February 2024

Abstract
Mercury (Hg) is severe toxic pollutants that pose a threat to the environment. Its accumulation alters various metabolic pathways by inducing oxidative stress and ultimately affects yield. Present study was conducted to explore how tartary buckwheat modulates its proteome and biomarkers in response to Hg stress. Plants were exposed to Hg (75µM) exposure for 15 days. Two-dimensional gel electrophoresis (2-DGE) was used for resolving leaf proteome and differential protein expression was studied using PDQuest software. Results showed that hydrogen peroxide (H2O2) and thiobarbituric acid reactive substance (TBARS) exhibited a concomitant increase under Hg-induced oxidative stress. Proteomic analysis showed that about 213 protein spots were reproducibly detected in control and 174 protein spots were differentially expressed under Hg stress, among which 12 were up-regulated and 19 were down-regulated. The differential protein expression suggests that tartary buckwheat modulates its leaf proteome subjected to Hg which might be an adaptive response mechanism by plants to Hg stress.