bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and Facilitators for the Use of Telehealth by Healthcare Providers (HCP) in India - A Scoping Review
Authors: Sharma Parth , Rao Shirish , Kumar Padmavathy Krishna , Nair Aiswarya R , Agrawal Disha , Zadey Siddhesh , Gayathri S , Joseph Rachna George , Dayma Girish , Rafeekh Liya , Saha Shubhashis , Sharma Sitanshi , Prakash SS , Sankarapandian Venkatesan , John Preethi , Patel Vikram 
Published: October 2023

AbstractBackgroundIt is widely assumed that telehealth tools like mHealth, telemedicine, and tele-education can supplement the efficiency of Healthcare Providers (HCPs). We conducted a scoping review of evidence on the barriers and facilitators associated with the use of telehealth by HCPs in India.MethodsA systematic literature search following a pre-registered protocol (https://doi.org/10.17605/OSF.IO/KQ3U9[PROTOCOL DOI]) was conducted in PubMed. The search strategy, inclusion, and exclusion criteria were based on the World Health Organization’s action framework on Human Resources for Health (HRH) and Universal Health Coverage in India with a specific focus on telehealth tools. Eligible articles published in English from 1st January 2001 to 17th February 2022 were included.ResultsOne hundred and six studies were included in the review. Of these, 53 studies (50%) involved mHealth interventions, 25 (23.6%) involved telemedicine interventions whereas the remaining 28 (26.4%) involved the use of tele-education interventions by HCPs in India. In each category, most of the studies followed a quantitative study design and were mostly published in the last 5 years. The study sites were more commonly present in states present in south India. The facilitators and barriers related to each type of intervention were analyzed under the following sub-headings-1) Human resource related, 2) Application related 3) Technical, and 4) Others. The interventions were most commonly used for improving the management of mental health, non-communicable diseases, and maternal and child health.ConclusionsUse of telehealth has not been uniformly studied in India. The facilitators and barriers to telehealth use need to be kept in mind while designing the intervention. Future studies should focus on looking at region-specific, intervention-specific, and health cadre-specific barriers and facilitators for the use of telehealth.
Insecticidal Effects of Datura Species against Major Agricultural Pests
Authors: Sharma Meenakshi , Singh Vikas Kumar , Chaturvedi Deepti , Delta Anil Kumar , Sharma Madan Mohan , Kaushik Prashant 
Published: October 2023

AbstractInsecticides derived from plants provide environmentally friendly and sustainable options as alternatives to synthetic chemicals. This investigation delves into the insecticidal capabilities of two distinct Datura species, namely, Datura alba and Datura stramonium, in combatting significant pests such asSpodoptera litura, Bemesia tabaci, andCallosobruchus maculatus. Datura plants have a well-documented history of medicinal use and are recognized for their abundant Tropane alkaloid content, which acts as an innate defense mechanism against pests. Hence, the current investigation involved the extraction of chemical compounds from the leaves, flowers, seeds, and roots of both Datura stramonium and Datura alba. Subsequently, these extracts were assessed for efficacy using Spodoptera litura larvae, Bemesia tabaci, andCallosobruchus maculatusin bioassays. The larvicidal experiments encompassed a range of concentrations (3%, 5%, 10%), with larval mortality being documented at multiple time intervals: 6, 12, 24, 48, and 72 hours. The findings from our investigation uncover the notable insecticidal attributes of root, leaf, flower, and seed extracts from bothDatura albaandDatura stramoniumagainst these larvae. These extracts demonstrated distinct mortality rates at various concentrations and exposure durations. This comprehensive analysis imparts crucial knowledge regarding the insecticidal qualities of Datura species and their prospective contributions to sustainable pest control practices. The observed effectiveness of these plant extracts against a spectrum of significant pests hints at their potential as ecological alternatives within integrated pest management strategies.
Individual variations in reward-seeking adaptability emerge among isogenic mice living in a micro-society and predict their response to nicotine
Authors: Fayad SL. , Reynolds LM. , Torquet N. , Tolu S. , Mondoloni S. , Nguyen C. , Justo R. , Didienne S. , Debray N. , Viollet C. , Raynaud L. , Layadi Y. , Hannesse B. , Capaz A.-M. , Topilko T. , Renier N. , Mourot A. , Marti F. , Ph Faure 
Published: November 2023

SummaryIndividual animals differ in their traits and preferences, which shape their social interactions, survival, and susceptibility to disease, including addiction. Nicotine use is highly heterogenous, and has been linked to the expression of personality traits. Although these relationships are well-documented, we have limited understanding of the neurophysiological mechanisms that give rise to distinct personalities and their connection to nicotine susceptibility. To address this question, we conducted a study using a semi-natural and social environment called “Souris-City” to observe the long-term behavior of individual mice. Souris-City provided both a communal living area and a separate test area where mice engaged in a reward-seeking task isolated from their peers. Mice developed individualistic reward-seeking strategies when choosing between water and sucrose in the test compartment, which, in turn, predicted how they adapted to the introduction of nicotine as a reinforcer. Moreover, mouse profiles in isolation also extended to correlate with their behavior within the social environment, linking decision-making strategies to the expression of behavioral traits. Neurophysiological markers of adaptability within the dopamine system were apparent upon nicotine challenge, and were associated with specific profiles. Our findings suggest that environmental adaptations influence behavioral traits and sensitivity to nicotine by acting on dopaminergic reactivity in the face of nicotine exposure, potentially contributing to addiction susceptibility. These results further emphasize the importance of understanding inter-individual variability in behavior to gain insight into the mechanisms of decision making and addiction.
Latitude-Driven Functional Trait Variations inZizania latifolia: Insights into Climate Adaptation
Authors: Jiang Hongsheng , Fan Xiangrong , Wagutu Godfrey Kinyori , Li Wei , Chen Yuanyuan 
Published: October 2023

ABSTRACTThe global warming could have significant impact on plant adaptation to local environments. Widespread species provides a useful model to examine the population dynamic under climate change. However, it is still unclear how widespread aquatic species response to rapidly changing environments. Wild-riceZizania latifoliais an emergent macrophyte widely distributed across East Asia. Here, 28Z. latifolianatural populations covering above 30 latitudes were transplanted in a common garden. The growth, photosynthesis and reproduction traits were quantified and compared among populations, and pairwise relationships among geographic and genetic variables were estimated. Results showed that, in the common garden, the high-latitude populations grew in small size indicating weaker competitiveness in warmer temperatures; the low-latitude populations had no sexual reproduction, suggesting that low-latitude individuals stood little chance to migrate successfully to higher latitude. Significant positive correlations among the distances of genetic, geographic and morphological traits for populations indicated that both isolation by distance and isolation by environment models affected the genetic pattern of populations, and phenotypic traits ofZ. latifoliapopulations might be genetically determined. All our data suggest thatZ. latifoliawould be inadaptable to the global warming, indicating that this species would be at least at risk of local extinction in the warmer future.
Projections of wastewater as an indicator of COVID-19 cases in corrections facilities: a modelling study
Authors: Han Dan , Linares Pamela , Holm Rochelle H. , Chandran Kartik , Smith Ted 
Published: November 2023

AbstractBackgroundAlthough prison facilities are not fully isolated from the communities they are located within, the majority of the population is confined and requires high levels of health vigilance and protection. This study sought to examine the dynamic relationship between facility level wastewater viral RNA concentration and probability of at least one positive COVID-19 case within the facility.MethodsThe study period was January 11, 2021 through May 12, 2023. Wastewater samples were collected and analyzed for SARS-CoV-2 (N1) and pepper mild mottle virus (PMMoV) three times per week across 14 prison facilities in Kentucky (USA). Confirmed positive clinical case reports were also provided. A hierarchical Bayesian spatial-temporal model with a latent lagged process was developed.FindingsWe modeled a facility-specific SARS-CoV-2 (N1) normalized by PMMoV wastewater ratio associated with at least one COVID-19 facility case with an 80% probability. The ratio differs among facilities. Across the 14 facilities, our model demonstrates an average capture rate of 94·95% via the N1/PMMoV threshold withpts≥ 0·5. However, it is noteworthy as theptsthreshold is set higher, such as at 0·9 or above, the model’s average capture rate reduces to 60%. This robust performance underscores the model’s effectiveness in accurately detecting the presence of positive COVID-19 cases of incarcerated people.InterpretationThe findings of this study provide a correction facility-specific threshold model for public health response based on frequent wastewater surveillance.
Assembly of continuous high-resolution draft genome sequence ofHemicentrotus pulcherrimususing long-read sequencing
Authors: Komoto Tetsushi , Ikeo Kazuho , Yaguchi Shunsuke , Yamamoto Takashi , Sakamoto Naoaki , Awazu Akinori 
Published: November 2023

ABSTRACTThe update of the draft genome assembly of sea urchin,Hemicentrotus pulcherrimus, which is widely studied in East Asia as a model organism of early development, was performed using Oxford nanopore long-read sequencing. The updated assembly provided ∼600 Mb genome sequences divided into 2,163 contigs with N50 = 516 kb. BUSCO completeness score and transcriptome model mapping ratio (TMMR) of the present assembly were obtained as 96.5 % and 77.8 % respectively. These results were more continuous with higher resolution than those by the previous version ofH. pulcerrimusdraft genome, HpulGenome_v1, where the number of scaffolds = 16,251 with a total of ∼100 Mb gaps, N50 = 143 kb, BUSCO completeness score = 86.1 %, and TMMR = 40.61. The obtained genome contained 36,055 gene models that were consistent with those in other echinoderms. Additionally, two tandem repeat sequences of early histone gene locus containing 47 copies and 34 copies of all histone genes, and 185 of the homologous sequences of the interspecifically conserved region of theArsinsulator, ArsInsC, were obtained. These results provide further advance for genome-wide research of development, gene regulation, and intranuclear structural dynamics of multicellular organisms usingHemicentrotus pulcherrimus.
The influence of trust for sustainable agri-food production: empirical evidence of a mariculturist supply chain in Southern Brazil
Authors: Assis Michel Tavares Quinteiro Milcent , Lucas Maria Raquel David Pereira Ventura , Rainho Maria Matos 
Published: October 2023

PurposeThe purpose of this work is to study the relationships of trust in a local agri-food supply chain in Southern Brazil. In an unsustainable context, where the number of mariculturists is decreasing, the authors seek to identify what the factors are and how they contribute to this problem, as well as find solutions aimed at the sustainability of that chain.Design/methodology/approachThe authors carried out qualitative research with 15 semi-structured interviews that took place in the year 2021. The thematic analysis of the results applied the IRAMUTEQ software and the assessment of the narratives was guided by prior thematic analysis.FindingsThe supply chain under investigation requires better organisation. Communication and interpersonal trust proved important in the relationship between producers and control bodies. The university, as a seed supplier, needs predictability and efficiency to convey inter-organisational trust. Informal relationships are interpersonal and extremely trust-based and inter-organisational trust increases the performance of establishments and promotes the development of innovative structures. Furthermore, in crisis periods interpersonal trust increases.Practical implicationsThe results allow policymakers to plan better their actions and build more effective tactics in order to reach sustainable development. This work is also important for stakeholders and managers, as it guides improvements in management, governance and sustainability of agri-food supply chains.Originality/valueAn unprecedented research was done on the studied supply chain, knowing the relationships of trust among them, identifying peculiar partnerships and recognising some constructs and outcomes of trust.
Effect of solid obstacle and thermal conditions on convective flow and entropy generation of nanofluid filled in a cylindrical chamber
Authors: Swamy H.A. Kumara , Mani Sankar , Reddy N. Keerthi , Do Younghae 
Published: November 2023

Purpose
One of the major challenges in the design of thermal equipment is to minimize the entropy production and enhance the thermal dissipation rate for improving energy efficiency of the devices. In several industrial applications, the structure of thermal device is cylindrical shape. In this regard, this paper aims to explore the impact of isothermal cylindrical solid block on nanofluid (Ag – H2O) convective flow and entropy generation in a cylindrical annular chamber subjected to different thermal conditions. Furthermore, the present study also addresses the structural impact of cylindrical solid block placed at the center of annular domain.

Design/methodology/approach
The alternating direction implicit and successive over relaxation techniques are used in the current investigation to solve the coupled partial differential equations. Furthermore, estimation of average Nusselt number and total entropy generation involves integration and is achieved by Simpson and Trapezoidal’s rules, respectively. Mesh independence checks have been carried out to ensure the accuracy of numerical results.

Findings
Computations have been performed to analyze the simultaneous multiple influences, such as different thermal conditions, size and aspect ratio of the hot obstacle, Rayleigh number and nanoparticle shape on buoyancy-driven nanoliquid movement, heat dissipation, irreversibility distribution, cup-mixing temperature and performance evaluation criteria in an annular chamber. The computational results reveal that the nanoparticle shape and obstacle size produce conducive situation for increasing system’s thermal efficiency. Furthermore, utilization of nonspherical shaped nanoparticles enhances the heat transfer rate with minimum entropy generation in the enclosure. Also, greater performance evaluation criteria has been noticed for larger obstacle for both uniform and nonuniform heating.

Research limitations/implications
The current numerical investigation can be extended to further explore the thermal performance with different positions of solid obstacle, inclination angles, by applying Lorentz force, internal heat generation and so on numerically or experimentally.

Originality/value
A pioneering numerical investigation on the structural influence of hot solid block on the convective nanofluid flow, energy transport and entropy production in an annular space has been analyzed. The results in the present study are novel, related to various modern industrial applications. These results could be used as a firsthand information for the design engineers to obtain highly efficient thermal systems.
Investigating the unexpected determinants of cryptocurrency adoption in the UAE
Authors: Jegerson Devid , Mertzanis Charilaos , Khan Mehmood 
Published: October 2023

PurposeFinancial inclusion provides access to financial infrastructure, facilitating money transfers. Therefore, blockchain and cryptocurrencies might boost worldwide financial acceptance. However, the UAE has one of the lowest cryptocurrency adoption rates. This study explores the UAE customer adoption and use of cryptocurrencies.Design/methodology/approachUsing a scale, the authors created a structural model and obtained 270 responses from a snowball-distributed online questionnaire, assessed by five cryptocurrency specialists.FindingsPerformance expectations (PE), price value (PV), Hedonic motivation (HM) and consumer innovativeness (CI) were the most significant predictors of behavioural intention (BI). Surprisingly, BI is not a reliable indication of actual consumption. Facilitating conditions (FC) are the most accurate predictor of cryptocurrency usage (CU), indicating that adoption might be increased by providing the necessary structures and processes to lead users.Research limitations/implicationsThis research adds to the body of knowledge by examining the adoption and implementation of cryptocurrencies in the UAE and by developing and evaluating new constructs based on current notions. The study also contributes to the current understanding of cryptocurrencies and blockchain adoption.Practical implicationsThe conclusions of the research advise marketers on how to boost the commercialisation of cryptocurrencies in the UAE market and may pave the way for other studies to assist impending developments in the UAE cryptocurrency industry.Originality/valueThis research offers novel insights into significant predictors of cryptocurrency product uptake in the financial and banking business.
Apoptotic Nuclei Within the Uterine Decidua of First Trimester Pregnancy Arise from CD45 Positive Leukocytes
Authors: Hammer Astrid , Dohr Gottfried 
Published: October 2023

PROBLEM: The Fas/Fas‐ligand (FasL) system is discussed to be one of the main components responsible for the formation and maintenance of an immune privilege. As we were able to detect FasL on fetal trophoblast cells infiltrating the maternal uterine tissue and Fas on decidual leukocytes (Hammer et al., Am J Reprod Immunol, 1999; 41: 41–51), we investigated whether apoptosis occurs in the maternal decidua during the first trimester of pregnancy.METHOD OF STUDY: A TUNEL‐assay was performed in combination with immunofluorescence to detect and characterize cells undergoing apoptosis.RESULTS: Apoptotic nuclei mainly arising from CD45+ leukocytes could be detected in the trophoblast‐invaded decidua basalis as well as in the non‐invaded decidua parietalis. However, while in the decidua parietalis the apoptotic leukocytes are scattered within the whole functional stroma, in the decidua basalis they are concentrated in the area around the so‐called “necrotic foci” and especially in the primary feto–maternal contact zone, where trophoblast cells from the cell columns begin to invade the maternal tissue.CONCLUSION: Because of the irregular distribution of apoptotic CD45+ leukocytes in the decidua basalis we think that some of the maternal leukocytes are activated and killed by fetal trophoblast cells which express FasL.
Progress in Characterization of Pre‐Implantation Factor in Embryo Cultures and In Vivo
Authors: Barnea E.R. , Simon J. , Levine S.P. , Coulam C.B. , Taliadouros G.S. , Leavis P.C. 
Published: October 2023

PROBLEM: Pre‐implantation factor (PIF), a small, embryo‐derived peptide is detected in the maternal serum prior to implantation and is associated with successful pregnancy outcome. However, its identity is not known.METHOD OF STUDY: PIF was isolated from mouse embryo conditioned media and from pregnant porcine sera, using high‐performance liquid chromatography (HPLC) followed by mass spectrometry.RESULTS: Conditioned culture media was separated by gel filtration chromatography followed by reversed phase chromatography. At each step, PIF activity was determined by the lymphocyte/platelet binding autorosette assay (LPBA). Mass spectrometry yielded a single peak with a mass of 1300 Da. The peptide is, however, present in very low concentrations (fM), which has so far precluded complete identification. Pregnant porcine sera that exhibit potent PIF activity were deproteinated by acetone and further fractionated by reversed phase HPLC. Active fractions contain peptides of molecular masses 523 and 551 Da.CONCLUSION: PIF, likely to be peptides, represents a novel substance related to pregnancy initiation and maintenance.
Berberine alleviates contrast‐induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway
Authors: Wang Wanpeng , Yu Ran , Wu Caixia , Li Qingju , Chen Jiajia , Xiao Yao , Chen Haoyu , Song Jian , Ji Mingyue , Zuo Zhi 
Published: November 2023

AbstractContrast‐induced nephropathy (CIN) is a condition that causes kidney damage in patients receiving angiography with iodine‐based contrast agents. This study investigated the potential protective effects of berberine (BBR) against CIN and its underlying mechanisms. The researchers conducted both in vivo and in vitro experiments to explore BBR's renal protective effects. In the in vivo experiments, SD rats were used to create a CIN model, and different groups were established. The results showed that CIN model group exhibited impaired renal function, severe damage to renal tubular cells and increased apoptosis and ferroptosis. However, BBR treatment group demonstrated improved renal function, decreased apoptosis and ferroptosis. Similar results were observed in the in vitro experiments using HK‐2 cells. BBR reduced ioversol‐induced apoptosis and ferroptosis, and exerted its protective effects through Akt/Foxo3a/Nrf2 signalling pathway. BBR administration increased the expression of Foxo3a and Nrf2 while decreasing the levels of p‐Akt and p‐Foxo3a. In conclusion, this study revealed that BBR effectively inhibited ioversol‐induced apoptosis and ferroptosis in vivo and in vitro. The protective effects of BBR were mediated through the modulation of Akt/Foxo3a/Nrf2 signalling pathway, leading to the alleviation of CIN. These findings suggest that BBR may have therapeutic potential for protecting against CIN in patients undergoing angiography with iodine‐based contrast agents.
Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis)
Authors: Schwartz K. , Zhang M. , Franco B. , Jampachaisri K. , Cotton R. M. , Huss M. K. , Fisher K. M. , Darian‐Smith C. , Sharp P. , Pablo L. , Pacharinsak C. 
Published: November 2023

AbstractBackgroundAtipamezole, an α‐2 adrenergic receptor antagonist, reverses the α‐2 agonist anesthetic effects. There is a dearth of information on the physiological effects of these drugs in cynomolgus macaques (Macaca fascicularis). We assessed atipamezole's physiologic effects. We hypothesized atipamezole administration would alter anesthetic parameters.MethodsFive cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0.5 mg/kg). Anesthetic parameters (heart rate, blood pressure [systolic (SAP), diastolic (DAP), and mean (MAP) blood pressure], body temperature, respiratory rate, and %SpO2) were monitored prior to and every 10 min (through 60 min) post atipamezole injection.ResultsWhile heart rate was significantly increased for 60 min; SAP, DAP, MAP, and temperature were significantly decreased at 10 min.ConclusionsThis study indicates subcutaneous atipamezole results in increased heart rate and transient blood pressure decrease. These findings are clinically important to ensure anesthetist awareness to properly support and treat patients as needed.