bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the six-minute walking distance measured by FeetMe® insoles
Authors: Mostovov Andrey , Jacobs Damien , Farid Leila , Dhellin Paul , Baille Guillaume 
Published: October 2023

Abstract
Background
The six-minute walk test (6MWT) is widely used to assess functional capacity in patients with various diseases. Use of wearable devices can make this test more accurate and easier to administer, and may even enhance it by providing additional information. The purpose of this study was to evaluate the validity of FeetMe® insoles for assessing the total six-minute walking distance (6MWD) by comparing the FeetMe® estimates and those obtained by a rater to the ground truth measured with a surveyor’s wheel.

Results
Data were analyzed from healthy volunteers who performed the 6MWT on 10-m and 30-m tracks while wearing FeetMe® insoles (n = 32), and being simultaneously assessed by a rater (n = 33) and followed by an investigator with a surveyor’s wheel. The mean average error (MAE) of the estimates was below 13 m on both tracks for FeetMe®, whereas it ranged from 16.24 m to 38.88 m on the 30-m and 10-m tracks for the rater.

Conclusion
The FeetMe® insoles provided a more accurate estimate and showed greater agreement with the ground truth than the rater, and the accuracy of the FeetMe® estimates did not vary according to the track length. We conclude that the FeetMe insoles are a valid solution for measuring the 6MWD.
lncRNA Hnscr Regulates Lipid Metabolism by Mediating Adipocyte Lipolysis
Authors: Guo Yi-Fan , Sun Jing-Yi , Liu Ya , Liu Zhe-Yu , Huang Yan , Xiao Yuan , Su Tian 
Published: October 2023

Abstract
Obesity is a process of fat accumulation due to the imbalance between energy intake and consumption. Long noncoding RNA (lncRNA) Hnscr is crucial for metabolic regulation, but its roles in lipid metabolism during obesity are still unknown. In this article, we found that the expression of Hnscr gradually decreased in adipose tissues of diet-induced obese mice. Furthermore, the deletion of Hnscr promoted an increase in body weight and adipose tissue weight by upregulating the expression of lipogenesis genes and downregulating lipolysis genes in inguinal white adipose tissue (iWAT) and brown adipose tissue. In vitro knockdown of Hnscr in adipocytes resulted in reduced lipolysis of adipocytes. Overexpression of Hnscr by adenovirus or drug mimics showed the opposite. Mechanistically, Hnscr regulated adipose lipid metabolism by mediating the cyclic adenosine monophosphate/protein kinase A signaling pathway. This study identifies the initial characterization of Hnscr as a critical modifier that regulates lipid metabolism, suggesting that lncRNA Hnscr is a potential target for treating obesity.
Impressions of science and healthcare professionals who share anti-science conspiracy theories
Authors: Green Ricky , Toribio-Flórez Daniel , Douglas Karen M. 
Published: October 2023

Background: The majority of science and healthcare professionals agree with the scientific consensus on issues such as anthropogenic climate change and the safety and efficacy of vaccines. However, a small number of professionals diverge from this consensus and espouse conspiracy theories arguing, for example, that climate change is a hoax and that the dangers of vaccines are being hidden by greedy pharmaceutical companies. What impressions do people make of conspiracy-sharing professionals and, importantly, would people follow their advice? We aimed to answer these questions in a brief report comprising of two preregistered experiments. Methods: In Experiment 1 (N = 296) participants rated their impressions of a scientist who endorsed (vs. refuted) climate change conspiracy theories, and indicated their willingness to follow the scientist’s advice. Experiment 2 (N = 280) followed a similar method but focused on a healthcare professional who endorsed (vs. refuted) mRNA vaccine conspiracy theories. In a control condition, the professional provided neutral information. Results: In both experiments, people formed negative impressions of the conspiracy-sharing professional, perceiving them to be less trustworthy, honest, brave (Experiment 1 only), credible, intelligent, less able to effect change, and more of an outsider and a fraud. They also showed less willingness to follow the professionals’ advice. However, participants’ own conspiracy beliefs shaped these impressions, with stronger negative impressions found among participants with weaker conspiracy beliefs. Notably, higher conspiracy believers perceived the conspiracy-sharing professionals as braver. Conclusions: These findings suggest that scientific and healthcare professionals who share conspiracy theories are perceived negatively, and people are less willing to follow advice. However, this is moderated by participants’ own conspiracy beliefs.
Opłata paszportowa – charakter prawny, konstrukcja, funkcje i przeznaczenie wpływów
Authors: Ofiarski Zbigniew 
Published: October 2023

W opracowaniu przedstawiono elementy prawnej konstrukcji opłaty paszportowej, zidentyfikowano jej charakter prawny, realizowane funkcje oraz dokonano analizy zasad poboru tej opłaty unormowanych w przepisach ustawy o dokumentach paszportowych. Wniesienie opłaty paszportowej jest niezbędnym warunkiem wszczęcia procedury w sprawie wydania lub odmowy wydania paszportu. Obowiązek ich wnoszenia związany jest z wydawaniem paszportów oraz paszportów tymczasowych i nie obejmuje procedury wydawania paszportów dyplomatycznych i służbowych. Opłaty paszportowe są źródłem dochodów budżetu państwa pobieranych przez wojewodów i konsulów. W ustawie o dokumentach paszportowych ustalono przedmiot opłaty paszportowej, podmioty zobowiązane do jej wnoszenia, zwolnienia z tego obowiązku oraz zasady określania przez Radę Ministrów stawek tych opłat, w tym również stawek obniżonych. W celach porównawczych poddano analizie wybrane akty prawne normujące zakres stosowania opłat paszportowych w Polsce w okresie międzywojennym i w latach poprzedzających transformację ustrojowo-gospodarczą zapoczątkowaną w 1990 r. W opracowaniu pozytywnie zweryfikowano tezę o publicznoprawnym charakterze opłaty paszportowej. Ustalono, że pełnione są przez nią funkcje fiskalne i pozafiskalne. W toku prowadzonych badań zastosowano metodę dogmatycznoprawną oraz uzupełniająco metodę empiryczno-analityczną.
Housing Cycles and Exchange Rates
Authors: Ma Sai , Zhang Shaojun 
Published: October 2023

This paper documents that the ratio of residential-to-nonresidential investment is a strong in-sample and out-of-sample predictor for the dollar up to 12 quarters. The predictability is robust to a battery of additional checks and holds for other G10 currencies. We explain the predictability in an analytical model with time-varying housing preference, productivity, and volatility. In the model, the U.S. housing investment share is higher during periods with higher growth and lower uncertainty, corresponding to lower future nontradable prices, dollar index, and excess returns. We find strong empirical support for the channel. Alternative explanations, including the business and financial cycle, find less empirical support. This paper was accepted by David Sraer, finance. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4932 .
Os espaços de circulação dos provedores da Misericórdia. Uma análise sobre os locais de atuação dos gestores da caridade no Rio de Janeiro (c. 1640 – c. 1780)
Authors: Marques Machado Karoline 
Published: October 2023

O presente artigo analisa os espaços de atuação, nas esferas política e administrativa, dos indivíduos que atuaram como provedores, entre os anos de 1640 e 1780, na Irmandade de Nossa Senhora da Misericórdia do Rio de Janeiro. Acreditamos que ao olhar além dos muros da confraria, ponto de partida de nossa investigação, poderemos responder quais os motivos que levaram os homens de notada distinção e qualidade optarem por reforçar a sua diferenciação social ao assumir o compromisso com à caridade. Destacamos o artigo em tela desloca o ponto de partida – a partir de um espaço não hegemônicos, o Rio de Janeiro – para compreender as dinâmicas que conectam espaços tão vastos quanto os que constituíram a mundialização ibérica.
ANÁLISE FÍSICO-QUÍMICA E DE METAIS POTENCIALMENTE CONTAMINANTES EM ÁGUAS DO CORRÉGO CRIMINOSO, BACIA DO RIO PARAGUAI, NO MUNICÍPIO DE COXIM-MS
Authors: Da Silva Gomes Paulo Eduardo , Viana Jéssica Girello Motta , Martins Miranda Wilson Alex , Da Silva Geilson Rodrigues , De Oliveira Hygor Rodrigues 
Published: October 2023

A água é essencial para a existência de vida e têm várias aplicações como a utilização para consumo humano, higiene pessoal, atividades domésticas, comerciais, agrícolas e indústrias. Por ser um dos constituintes de maior importância em qualquer organismo, a água precisa estar em padrões físicos e químicos de qualidade para ser utilizada, seja ingestão, irrigação ou recreação. Sendo assim, este trabalho investigou a influência da urbanização nas águas superficiais do córrego Criminoso pertencente a bacia do Rio Paraguai no município de Coxim- MS, por meio de análises e monitoramento dos parâmetros físico-químicos, pH, oxigênio dissolvido (OD), turbidez, cor verdadeira, dureza total, condutividade elétrica (CE), cloretos totais, alcalinidade, sólidos totais dissolvidos (STD) e a influência de metais potencialmente contaminantes, Cu, Fe, Ni, Cd e Pb. A partir dos resultados obtidos, observamos que alguns parâmetros físico-químicos (pH, turbidez e cloretos) e o metais Cu, Ni Cd e Pd avaliados estavam de acordo com a legislação vigente em todos os pontos nos períodos analisados. Foram encontrado valores acima do permitido para Cor e Fe em todos os 4 pontos, para Oxigênio Dissolvido somente nos pontos 2 e 3, e para Condutividade Elétrica e Sólidos Totais Dissolvidos somente no ponto 2. Portanto, podemos apontar que a urbanização não planejada nas proximidades do córrego está afetando de forma negativa a qualidade das águas
‘I don't feel good about myself and sex’: sexual health experiences of women with gynaecological cancer in Ghana
Authors: Amenuvor Wonder Andrea Yayra , Wudagli Peace Mawufemor , Amissah-Essel Salome , Enyan Nancy Innocentia Ebu 
Published: October 2023

Background/Aims Patients with gynaecological cancer undergoing treatment face numerous challenges, including issues surrounding sexual health. Sexual health is an important aspect of human life, and the negative impact of gynaecological cancer, its treatments and any side effects may cause physical, emotional and psychological distress. In sub-Saharan Africa, sexual health and childbirth form the core of marital relationships; changes in sexual response and function as a result of cancer can lead to dysfunctional relationships. This study explored the sexual health experiences of patients with gynaecological cancer at the Korle Bu Teaching Hospital in Ghana. Methods This study used an exploratory, descriptive, qualitative design. A total of 12 adults with gynaecological cancer (cervical, endometrial and ovarian) were purposively selected from the Korle Bu Teaching Hospital. Data were collected with a semi-structured interview guide through face-to-face or telephone interviews. Data were analysed using thematic analysis. Results Four themes emerged: changes to the sex organ, changes in sex life, anxiety about treatment outcome and coping strategies. The participants had generally had healthy sex lives before being diagnosed with cancer. Psychologically, participants experienced anxiety and lacked interest in sex. Physical effects included bleeding, changes to the female organ and pain. The participants self-stigmatised in the form of low self-esteem and separation. They coped through religious means, family support and health education. Conclusions There is a need for psychosocial interventions in the care of women with gynaecological cancers, including measures to support coping with the physical effects of the condition and its treatment. It is recommended that stakeholders in cancer care are made aware of, and make efforts to include in their care, spirituality, family support and health education.
Excretory/Secretory Products from Schistosoma japonicum Eggs Alleviate Ovalbumin-Induced Allergic Airway Inflammation
Authors: Li Zhidan , Wang Xiaoling , Zhang Wei , Yang Wenbin , Xu Bin , Hu Wei 
Published: October 2023

Introduction
Excretory/secretory products (ESPs) derived from helminths have been reported to effectively control allergic inflammation, which have better therapeutic prospects than live parasite infections. However, it remains unknown whether ESPs from schistosome eggs can protect against allergies, despite reports alleging that schistosome infection could alleviate disordered allergic inflammation.

Method
In the present study, we investigated the protective effects of ESPs from Schistosoma japonicum eggs (ESP-SJE) on asthmatic inflammation. Firstly, we successfully established an allergic airway inflammation model in mice by alum-adjuvanted ovalbumin (OVA) sensitization and challenge. ESP-SJE were administered intraperitoneally on days -1 and 13 (before sensitization), on day 20 (before challenge), and on days 21–24 (challenge phase).

Results
The results showed that ESP-SJE treatment significantly reduced the infiltration of inflammatory cells, especially eosinophils into the lung tissue, inhibited the production of the total and OVA-specific IgE during OVA-sensitized and -challenged phases, respectively, and suppressed the secretion of Th2-type inflammatory cytokines (IL-4). Additionally, ESP-SJE treatment significantly upregulated the regulatory T cells (Tregs) in the lung tissue during OVA challenge. Furthermore, using liquid chromatography-mass spectrometry analysis and Treg induction experiments in vitro, we might identify nine potential therapeutic proteins against allergic inflammation in ESP-SJE. The targets of these candidate proteins included glutathione S-transferase, egg protein CP422 precursor, tubulin alpha-2/alpha-4 chain, actin-2, T-complex protein 1 subunit beta, histone H₄, whey acidic protein core region, and molecular chaperone HtpG.

Conclusion
Taken together, the results discussed herein demonstrated that ESP-SJE could significantly alleviate OVA-induced asthmatic inflammation in a murine model, which might be mediated by the upregulation of Treg in lung tissues that may be induced by the potential modulatory proteins. Therefore, potential proteins in ESP-SJE might be the best candidates to be tested for therapeutic application of asthma, thus pointing out to a possible new therapy for allergic airway inflammation.
Delayed blood pressure recovery after exercise stress test is associated with autonomic dysfunction and pulse pressure in a middle-aged healthy group
Authors: Lee Hancheol , Kim Hyeongsoo , Oh Seungjin , Park Jong-Kwan , Jang Ji-Yong , Chun Kyeong-Hyeon , Yoon Se-Jung 
Published: October 2023

BackgroundDelayed heart rate (HR) and blood pressure recovery after exercise test is known as the reliable indexes of autonomic dysfunction. Here we tried to evaluate the serial changes in various indicators during exercise test and correlations with recovery of HR and blood pressure in a normotensive healthy middle-aged group.MethodsA total of 122 patients without hypertension or diabetes was enrolled (mean age, 55.6 ± 11.0; male, 56.6%; mean blood pressure, 124.8 ± 16.6 / 81.5 ± 9.6 mmHg). Treadmill test was performed for evaluation of chest pain. Patients with coronary artery disease, positive treadmill test result, left ventricular dysfunction or renal failure were excluded. Heart rate recovery was calculated by subtracting the HR in the first or second minute of recovery period from the HR of peak exercise (HRR1 or HRR2). Systolic blood pressure in the 4thminute of recovery stage (SBPR4) was used to show delayed blood pressure recovery.ResultsMetabolic equivalents (METs) and HR in stage 2 to 4 were significantly correlated with both HRR1 and HRR2. Multiple regression analysis of HRR revealed significant correlation of METs and SBPR4. SBPR4 was significantly correlated with both HRR1 and HRR2 (HRR1, r = -0.376, p<0.001; HRR2, r = -0.244, p = 0.008) as well as SBP in the baseline to stage 3 and pulse pressure (r = 0.406, p<0.001).ConclusionsDelayed BP recovery after peak exercise test revealed significant association with autonomic dysfunction and increased pulse pressure in normotensive middle-aged healthy group. It can be a simple and useful marker of autonomic dysfunction and arterial stiffness.
Second victim syndrome in intensive care unit healthcare workers: A systematic review and meta-analysis on types, prevalence, risk factors, and recovery time
Authors: Naya Kazuaki , Aikawa Gen , Ouchi Akira , Ikeda Mitsuki , Fukushima Ayako , Yamada Shuhei , Kamogawa Megumi , Yoshihara Shun , Sakuramoto Hideaki 
Published: October 2023

Introduction
Patient safety incidents, including medical errors and adverse events, frequently occur in intensive care units, leading to a significant psychological burden on healthcare workers. This burden results in second victim syndrome, which impacts the psychological and psychosomatic well-being of these workers. However, a systematic review focusing specifically on this condition among intensive care unit healthcare workers is lacking. Therefore, we aimed to conduct a systematic review and meta-analysis to examine the occurrence of second victim syndrome among intensive care unit healthcare workers, including the types, prevalence, risk factors, and recovery time associated with this condition.

Methods
We conducted a comprehensive search of the MEDLINE, CINAHL, PsycINFO, and Igaku Chuo Zasshi databases. The eligibility criteria encompassed retrospective, prospective, and cross-sectional studies and controlled trials, with no language restrictions. Data on the type, prevalence, risk factors, and recovery time of second victim syndrome were extracted and pooled. Prevalence estimates from the included studies were combined using a random-effects meta-analytic model.

Results
Of the 2,245 records retrieved, 16 potentially relevant studies were identified. Following full-text evaluation, five studies met the inclusion criteria and were included in the review. The findings revealed that 58% of intensive care unit healthcare workers experienced second victim syndrome. Frequent symptoms included guilt (12–68%), anxiety (38–63%), anger at self (25–58%), and lower self-confidence (7–58%). However, specific risk factors exclusive to intensive care unit healthcare workers were not identified in the review. Furthermore, approximately 20% of individuals took more than a year to recover or did not recover at all from the second victim syndrome.

Conclusions
Thus, this condition is prevalent among intensive care unit healthcare workers and may persist for extended periods, potentially exceeding a year. The risk factors for second victim syndrome in the intensive care unit setting are unclear and require further investigation.
KERAGAMAN STOMATA DAN ANALISIS KEKERABATAN GENOTIPE JAHE MERAH
Authors: Anggraheni Yuliana Galih Dyan , Mambrasar Yasper Michael , Mulyani Enung Sri , Perdani Ambar Yuswi , Paradisa Yashanti Berlinda , Sulityowati Yuli , Nuro Fiqolbi , Indrayani Sri , Burhana Nana , Sudarna Tatang , Rostiana Otih 
Published: October 2023

Jahe merupakan tanaman rempah-rempah yang berpotensi sebagai imunomodulator untuk meningkatkan sistem kekebalan tubuh manusia. Senyawa gingerol dilaporkan memiliki aktivitas imunomodulator dan imunosupresan. Informasi mengenai keragaman stomata genotipe lokal jahe merah diperlukan untuk melengkapi deskripsi genotipe jahe merah yang digunakan sebagai dasar kegiatan pemuliaan tanaman jahe merah. Observasi morfologi daun dilakukan dengan mengamati jumlah, panjang, dan lebar stomata, serta jumlah kloroplas. Data yang diperoleh dianalisis dengan menggunakan peranti lunak IBM SPSS versi 25 dan PAST 3.25. Hasil penelitian menunjukkan bahwa dari 14 genotipe jahe lokal koleksi pada 4 karakter pengamatan sitologi menunjukkan bahwa rerata panjang stomata, lebar stomata, dan jumlah kloroplas berbeda nyata. Sementara karakter rerata jumlah stomata tidak berbeda nyata antar genotipe jahe merah. Analisis lanjut dilakukan dengan metode DMRT, terlihat bahwa panjang stomata pada genotipe Ziof-110 (60,1µm) berbeda nyata dengan Ziof-68 (66,3 µm). Pada karakter lebar stomata secara statistik Ziof-108 (66,7 µm) berbeda nyata dengan Ziof-69 (70,3 µm) dan Ziof-70 (69 µm). Karakter jumlah kloroplas Ziof-72 (30) berbeda nyata dengan Ziof-13 (46) dan Ziof-115 (43). Dendogram kekerabatan dan analisis komponen utama membagi 14 genotipe jahe merah lokal menjadi 2 kelompok. lebar stomata dan jumlah kloroplas merupakan karakter yang berkontribusi terhadap keragaman jahe merah dengan nilai PC1 0,70 dan PC2 0,73. Komponen utama 1 dan 2 memiliki nilai eigenvalue > 1 dan dapat menjelaskan keragaman total jahe merah sebesar 65,24%.
AKTIVITAS XILANASE DARI Bacillus altitudinis YANG DIPRODUKSI DENGAN VARIASI WAKTU INKUBASI DAN KONDISI PENGUJIAN pH NETRAL DAN ALKALIN
Authors: Saputra Sugiyono , Hanoum Alida , Mulyadi Mulyadi , Dinoto Achmad 
Published: October 2023

Xylanases are hydrolytic enzymes which randomly cleave the β-1,4 backbone of the complex plant cell wall polysaccharide xylan. In this study, we investigate the extracellular enzyme activity of three strains of Bacillus altitudinis which produced with various production times in neutral (pH 7) and alkaline (pH 9) conditions. Crude enzyme was obtained from inoculated production medium containing 2% w/v xylan after six different time of incubations, including 0, 24, 48, 72, 96 and 120 hours. The stationary phase of those three strains was observed after 72 hours of incubation, in accordance with significant increase of xylanase activity both in neutral and alkaline assay conditions. However, the highest of xylanase activity was obtained after 92 hours of incubation, in all three bacterial strains tested. A thin layer chromatography (TLC) was performed, and it confirmed that the crudes enzymes was able to breakdown the xylan into oligosaccharides. A higher activity of xylanase was obtained in alkaline condition but not significantly different between those two conditions. B. altitudinis KBX08 has the highest xylanase activity (46.9U/ml) which produced after 96 hours of incubation, indicating their potential for further development as xylanase producer.
AKTIVITAS DAN KARAKTERISASI MIKOSIN ANTI Zygosaccharomyces rouxii FNCC 3006 DARI ISOLAT KHAMIR OSMOFILIK ASAL NEKTAR BUNGA DAN MADU
Authors: Janah Sovia Nur , Ilmi Miftahul 
Published: October 2023

Makanan berkadar gula tinggi (40-70%) dapat terkontaminasi oleh Zygosaccharomyces rouxii yang toleran terhadap tekanan osmotik, asam, alkohol, serta tahan terhadap bahan preservatif makanan. Salah satu cara menghambat pertumbuhan Z. rouxii adalah dengan memberikan mikosin anti Z. rouxii. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas dan karakterisasi mikosin anti Z. rouxii dari isolat khamir osmofilik. Penapisan aktivitas antagonistik dari isolat khamir osmofilik dilakukan dengan metode Colony Picking dan penapisan aktivitas ekstrak kasar dilakukan dengan Disk Diffusion Assay. Zona jernih yang terbentuk diukur untuk menentukan aktivitasnya dengan menggunakan indeks penghambatan (IP). Setelah itu dilakukan pengukuran berat kering sel dan karakterisasi mikosin menggunakan SDS PAGE. Hasil penelitian menunjukkan terdapat 10 isolat khamir osmofilik yang menghasilkan aktivitas antagonistik terhadap Z. rouxii yaitu isolat AP 1, PS 1.1, LW 1.1, BK 3.2, MR 3.2, AP 3, KS 1, dan TL 2.2 yang diisolasi dari madu, isolat BL 8.21 dan BL 8.22 yang diisolasi dari nektar bunga. Aktivitas ekstrak kasar mikosin anti Z. rouxii paling tinggi yaitu isolat LW 1.1 dengan nilai IP 1,28. Isolat paling efektif untuk menghambat pertumbuhan dari Z. rouxii adalah isolat LW 1.1, diperoleh nilai perbandingan zona hambat dengan berat kering yaitu 442,099. Isolat LW 1.1 menghasilkan anti-Z. rouxii dengan berat molekul antara 12,88 kDa sampai 72,92 kDa. Disimpulkan bahwa isolat LW 1.1 dapat dijadikan sumber penghasil mikosin anti-Z. rouxii yang dapat dimanfaatkan sebagai agen biokontrol dalam produk makanan.