bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protein–protein interaction analysis tool for targeted cross-linking mass spectrometry
Authors: Park Jongham , Son Ahrum , Kim Hyunsoo 
Published: December 2023

AbstractProtein networking is critical to understanding the biological functions of proteins and the underlying mechanisms of disease. However, identifying physical protein–protein interactions (PPIs) can be challenging. To gain insights into target proteins that interact with a particular disease, we need to profile all the proteins involved in the disease beforehand. Although the cross-linking mass spectrometry (XL-MS) method is a representative approach to identify physical interactions between proteins, calculating theoretical mass values for application to targeted mass spectrometry can be difficult. To address this challenge, our research team developed PPIAT, a web application that integrates information on reviewed human proteins, protein–protein interactions, cross-linkers, enzymes, and modifications. PPIAT leverages publicly accessible databases such as STRING to identify interactomes associated with target proteins. Moreover, it autonomously computes the theoretical mass value, accounting for all potential cross-linking scenarios pertinent to the application of XL-MS in SRM analysis. The outputs generated by PPIAT can be concisely represented in terms of protein interaction probabilities, complemented by findings from alternative analytical tools like Prego. These comprehensive summaries enable researchers to customize the results according to specific experimental conditions. All functions of PPIAT are available for free on the web application, making it a valuable tool for researchers studying protein–protein interactions.
scPML: pathway-based multi-view learning for cell type annotation from single-cell RNA-seq data
Authors: Du Zhi-Hua , Hu Wei-Lin , Li Jian-Qiang , Shang Xuequn , You Zhu-Hong , Chen Zhuang-zhuang , Huang Yu-An 
Published: December 2023

AbstractRecent developments in single-cell technology have enabled the exploration of cellular heterogeneity at an unprecedented level, providing invaluable insights into various fields, including medicine and disease research. Cell type annotation is an essential step in its omics research. The mainstream approach is to utilize well-annotated single-cell data to supervised learning for cell type annotation of new singlecell data. However, existing methods lack good generalization and robustness in cell annotation tasks, partially due to difficulties in dealing with technical differences between datasets, as well as not considering the heterogeneous associations of genes in regulatory mechanism levels. Here, we propose the scPML model, which utilizes various gene signaling pathway data to partition the genetic features of cells, thus characterizing different interaction maps between cells. Extensive experiments demonstrate that scPML performs better in cell type annotation and detection of unknown cell types from different species, platforms, and tissues.
Amplified nanoscale detection of labeled molecules via surface electrons on diamond
Authors: Biteri-Uribarren Ainitze , Alsina-Bolívar Pol , Munuera-Javaloy Carlos , Puebla Ricardo , Casanova Jorge 
Published: December 2023

AbstractThe detection of individual molecules and their dynamics is a long-standing challenge in the field of nanotechnology. In this work, we present a method that utilizes a nitrogen vacancy (NV) center and a dangling bond on the diamond surface to measure the coupling between two electronic targets tagged on a macromolecule. To achieve this, we design a multi-tone dynamical decoupling sequence that leverages the strong interaction between the nitrogen vacancy center and the dangling bond. In addition, this sequence minimizes the impact of decoherence finally resulting in an increased signal-to-noise ratio. This proposal has the potential to open up avenues for fundamental research and technological innovation in distinct areas such as biophysics and biochemistry.
Shifts in ophthalmic care utilization during the COVID-19 pandemic in the US
Authors: Li Charles , Lum Flora , Chen Evan M. , Collender Philip A. , Head Jennifer R. , Khurana Rahul N. , Cunningham Emmett T. , Moorthy Ramana S. , Parke David W. , McLeod Stephen D. 
Published: December 2023

AbstractBackgroundHealthcare restrictions during the COVID-19 pandemic, particularly in ophthalmology, led to a differential underutilization of care. An analytic approach is needed to characterize pandemic health services usage across many conditions.MethodsA common analytical framework identified pandemic care utilization patterns across 261 ophthalmic diagnoses. Using a United States eye care registry, predictions of utilization expected without the pandemic were established for each diagnosis via models trained on pre-pandemic data. Pandemic effects on utilization were estimated by calculating deviations between observed and expected patient volumes from January 2020 to December 2021, with two sub-periods of focus: the hiatus (March-May 2020) and post-hiatus (June 2020–December 2021). Deviation patterns were analyzed using cluster analyses, data visualizations, and hypothesis testing.ResultsRecords from 44.62 million patients and 2455 practices show lasting reductions in ophthalmic care utilization, including visits for leading causes of visual impairment (age-related macular degeneration, diabetic retinopathy, cataract, glaucoma). Mean deviations among all diagnoses are 67% below expectation during the hiatus peak, and 13% post-hiatus. Less severe conditions experience greater utilization reductions, with heterogeneities across diagnosis categories and pandemic phases. Intense post-hiatus reductions occur among non-vision-threatening conditions or asymptomatic precursors of vision-threatening diseases. Many conditions with above-average post-hiatus utilization pose a risk for irreversible morbidity, such as emergent pediatric, retinal, or uveitic diseases.ConclusionsWe derive high-resolution insights on pandemic care utilization in the US from high-dimensional data using an analytical framework that can be applied to study healthcare disruptions in other settings and inform efforts to pinpoint unmet clinical needs.
A semi-analytical thermal model for craters with application to the crater-induced YORP effect
Authors: Zhou Wen-Han , Michel Patrick 
Published: December 2023

Context. The YORP effect is the thermal torque generated by radiation from the surface of an asteroid. The effect is sensitive to surface topology, including small-scale roughness, boulders, and craters.
Aims. The aim of this paper is to develop a computationally efficient semi-analytical model for the crater-induced YORP (CYORP) effect that can be used to investigate the functional dependence of this effect.
Methods. This study linearizes the thermal radiation term as a function of the temperature in the boundary condition of the heat conductivity, and obtains the temperature field in a crater over a rotational period in the form of a Fourier series, accounting for the effects of self-sheltering, self-radiation, and self-scattering. By comparison with a numerical model, we find that this semi-analytical model for the CYORP effect works well for K > 0.1 Wm−1 K−1. This semi-analytical model is computationally three-orders-of-magnitude more efficient than the numerical approach.
Results. We obtain the temperature field of a crater, accounting for the thermal inertia, crater shape, and crater location. We then find that the CYORP effect is negligible when the depth-to-diameter ratio is smaller than 0.05. In this case, it is reasonable to assume a convex shape for YORP calculations. Varying the thermal conductivity yields a consistent value of approximately 0.01 for the spin component of the CYORP coefficient, while the obliquity component is inversely related to thermal inertia, declining from 0.004 in basalt to 0.001 in metal. The CYORP spin component peaks at an obliquity of 0°, 90°, or 180°, while the obliquity component peaks at an obliquity of around 45° or 135°. For a z-axis symmetric shape, the CYORP spin component vanishes, while the obliquity component persists. Our model confirms that the total YORP torque is damped by a few tens of percent by uniformly distributed small-scale surface roughness. Furthermore, for the first time, we calculate the change in the YORP torque at each impact on the surface of an asteroid explicitly and compute the resulting stochastic spin evolution more precisely.
Conclusions. This study shows that the CYORP effect due to small-scale surface roughness and impact craters is significant during the history of asteroids. The semi-analytical method that we developed, which benefits from fast computation, offers new perspectives for future investigations of the YORP modeling of real asteroids and for the complete rotational and orbital evolution of asteroids accounting for collisions. Future research employing our CYORP model may explore the implications of space-varying roughness distribution, roughness in binary systems, and the development of a comprehensive rotational evolution model for asteroid groups.
eROSITA studies of the Carina nebula
Authors: Sasaki Manami , Robrade Jan , Krause Martin G. H. , Knies Jonathan R. , Tsuge Kisetsu , Pühlhofer Gerd , Strong Andrew 
Published: December 2023

Context. During the first four all-sky surveys eRASS:4, which was carried out from December 2019 to 2021, the extended Roentgen Survey with an Imaging Telescope Array (eROSITA) on board the Spektrum-Roentgen-Gamma (Spektr-RG, SRG) observed the Galactic H II region, the Carina nebula.
Aims. We analysed the eRASS:4 data to study the distribution and spectral properties of the hot interstellar plasma and the bright stellar sources in the Carina nebula.
Methods. The spectral extraction regions of the diffuse emission were defined based on the X-ray spectral morphology and multi-wavelength data. The spectra were fit with a combination of thermal and non-thermal emission models. The X-ray bright point sources in the Carina nebula are the colliding wind binary η Car, several O stars, and Wolf–Rayet (WR) stars. We extracted the spectra of the brightest stellar sources, which can be well fit with a multi-component thermal plasma model.
Results. The spectra of the diffuse emission in the brighter parts of the Carina nebula are well reproduced by two thermal models, a lower-temperature component (~0.2 keV) and a higher-temperature component (0.6–0.8 keV). An additional non-thermal component dominates the emission above ~1 keV in the Central region around η Car and the other massive stars. Significant orbital variation in the X-ray flux was measured for η Car, WR 22, and WR 25. η Car requires an additional time-variable thermal component in the spectral model, which is associated with the wind-wind collision zone.
Conclusions. Properties such as temperature, pressure, and luminosity of the X-ray emitting plasma in the Carina nebula derived from the eROSITA data are consistent with theoretical calculations of emission from superbubbles. This confirms that the X-ray emission is caused by the hot plasma inside the Carina nebula that has been shocked-heated by the stellar winds of the massive stars, in particular, of η Car.
Ultraviolet H2luminescence in molecular clouds induced by cosmic rays
Authors: Padovani Marco , Galli Daniele , Scarlett Liam H. , Grassi Tommaso , Rehill Una S. , Zammit Mark C. , Bray Igor , Fursa Dmitry V. 
Published: December 2023

Context. Galactic cosmic rays (CRs) play a crucial role in ionisation, dissociation, and excitation processes within dense cloud regions where UV radiation is absorbed by dust grains and gas species. CRs regulate the abundance of ions and radicals, leading to the formation of more and more complex molecular species, and determine the charge distribution on dust grains. A quantitative analysis of these effects is essential for understanding the dynamical and chemical evolution of star-forming regions.Aims. The CR-induced photon flux has a significant impact on the evolution of the dense molecular medium in its gas and dust components. This study evaluates the flux of UV photons generated by CRs to calculate the photon-induced dissociation and ionisation rates of a vast number of atomic and molecular species, as well as the integrated UV photon flux.Methods. To achieve these goals, we took advantage of recent developments in the determination of the spectra of secondary electrons, in the calculation of state-resolved excitation cross sections of H2by electron impact, and of photodissociation and photoionisation cross sections.Results. We calculated the H2level population of each rovibrational level of theX, B, C, B′,D, B″,D′, andastates. We then computed the UV photon spectrum of H2in its line and continuum components between 72 and 700 nm, with unprecedented accuracy, as a function of the CR spectrum incident on a molecular cloud, the H2column density, the isomeric H2composition, and the dust properties. The resulting photodissociation and photoionisation rates are, on average, lower than previous determinations by a factor of about 2, with deviations of up to a factor of 5 for the photodissociation of species such as AlH, C2H2, C2H3, C3H3, LiH, N2, NaCl, NaH, O2+, S2, SiH, l-C4, and l-C5H. A special focus is given to the photoionisation rates of H2, HF, and N2, as well as to the photodissociation of H2, which we find to be orders of magnitude higher than previous estimates. We give parameterisations for both the photorates and the integrated UV photon flux as a function of the CR ionisation rate, which implicitly depends on the H2column density, as well as the dust properties.
X-ray digital imaging detection system for high-voltage equipment inspection
Authors: Darian Leonid , Obraztsov Roman , Nikitin Oleg 
Published: December 2023

In 2019 a portable diagnostic X-ray system was developed and tested for the inspection of high-voltage equipment (HVE). The system operates based on discrete radiography and is referred by the authors as the first generation X-ray system. As a result of critical analysis of the first generation system, it was further proposed to create a second generation mobile scanning system for HVE digital radiography which is for the first time applied in the power engineering. A physical and mathematical model was developed to establish the relationship between the energy spectrum of the source X-ray radiation and the contribution of this radiation to the image generation during HVE radiography. Using this model, the authors assess the efficiency of the unique X-ray machine used in the first generation X-ray system.
The main technical requirements for the second generation X-ray system, implementing digital scanning radiography, for examining HVE in operation are given.
Programm für die Veranstaltung des BDDH im Rahmen der 68. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung in Wien 2024 und Petition an den Deutschen Bundestag aufgrund eines drohenden Praxenkollaps
Authors: Koscielny Jürgen , Kappert Günther , Sucker Christoph 
Published: December 2023

Abstract
Veranstaltung des BDDH auf dem 68. GTH-Jahreskongress 2024
Vom 27.02. – 01.03.2024 findet der 68. Jahreskongress der Gesellschaft für Thrombose- und Hämostaseforschung in Wien statt. Im Rahmen des Kongresses findet auch eine Sitzung des Berufsverbandes der Deutschen Hämostaseologen (BDDH) statt. Den Vorsitz übernehmen Jürgen Koscielny als 1. Vorsitzender und Günther Kappert als 2. Vorsitzender des BDDH. Zunächst findet ein öffentlicher Teil statt, im Anschluss dann ein nicht-öffentlicher Teil nur für Mitglieder des BDDH. Der genaue Termin für die Veranstaltung des BDDH im Rahmen des Kongresses steht noch nicht fest.
Sollen Patienten nach gewaltsamen Übergriffen angezeigt werden?
Authors: Menzel Susanne , Brieger Peter 
Published: December 2023

ZUSAMMENFASSUNGAggressive Handlungen gegenüber Mitpatienten, Mitarbeitenden oder Besuchern durch Patienten sind ein Teil des Alltags akutpsychiatrischer Kliniken; nicht immer lassen sie sich verhindern. In manchen Fällen werden dabei Menschen verletzt, Klinikeinrichtung zerstört. Wie sind solche Ereignisse im Nachhinein zu bewerten? Wie kann eine angemessene Reaktion aussehen? Der Wunsch nach Normalisierung im Umgang mit psychisch kranken Menschen führt auch zur Frage der Eigenverantwortung für Verhalten, durch das Mitmenschen geschädigt oder gefährdet werden. Sollen Menschen, die als Patienten in der Obhut einer Klinik stehen, nach einem solchen Verhalten angezeigt werden? Wodurch ist eine solche Strafanzeige motiviert, wem dient sie, wem kann sie nützen, wem schaden? Der Artikel referiert die Überlegungen und Erwägungen aus einem Workshop zwischen Mitarbeitenden einer Klinik. Erste Anregungen zur Bewusstmachung des Spannungsfelds und zur Erarbeitung von Verhaltensempfehlungen für Kliniken werden formuliert.
Die Effekte von hochintensivem Intervalltraining in Fällen
mit Rekonstruktion des anterioren Kreuzbandes
Authors: Akaras Esedullah , Atalay Güzel Nevin , Kafa Nihan , Yağiz Gökhan , Odluyurt Mustafa , Ataoğlu Muhammet Baybars 
Published: December 2023

Zusammenfassung
Ziel Ziel dieser Studie ist es, die Auswirkungen eines
sechswöchigen (dreimal pro Woche) hochintensiven Intervalltrainings
(HIIT) im Wingate-Stil auf Kraft, Propriozeption, Flexibilität, Laxheit,
Leistung und Körperzusammensetzung bei Probanden zu untersuchen, die
sich einer Rekonstruktion des vorderen Kreuzbandes (ACL) mit der Methode der
Oberschenkel-Autotransplantation unterzogen haben.
Material und Methoden Im Rahmen der Studie wurden 29 Freiwillige, die sich
vor mindestens sechs Monaten einer autotransplantierten Kreuzbandrekonstruktion
der Oberschenkelmuskulatur unterzogen hatten, randomisiert und in zwei Gruppen,
HİİT (n=15) und Kontrollgruppen (n=14),
aufgeteilt. Nach den ersten Beurteilungen wurde der Wingate-Stil
HİİT sechs Wochen lang an drei Tagen in der Woche auf die
Versuchsgruppe angewendet. Die Kontrollgruppe setzte ihren normalen Lebensstil
und ihre normalen Bewegungsgewohnheiten fort. Nach sechs Wochen erfolgten
abschließende Auswertungen. Nach Erhalt der demografischen Informationen
der Probanden wurde die Körperzusammensetzung mit Tanita gemessen.
Anschließend wurden eine Messung der Knielaxität mit einem
GNRB-Arthrometer, 30°- und 60°-Propriozeption mit einem
isokinetischen Dynamometer sowie Muskelkraftmessungen (Quadrizeps femoris,
Oberschenkelmuskulatur (konzentrisch/exzentrisch) bei
60°/Sek.) und Ausdauermessungen bei 180°/Sek.
durchgeführt. Sitz- und Reichweitentest für Flexibilität
und Leistungsparameter (Einbeinsprung, Vertikalsprung, Beweglichkeit) wurden
gemessen.
Ergebnisse Den Ergebnissen zufolge wurde eine signifikante Abnahme der
Körperzusammensetzung ( p < 0,001), Steigerung der Kraft im
konzentrischen Quadrizeps (p < 0,001) und der hinteren
Oberschenkelmuskulatur (p < 0,001). Eine Verbesserung wurde bei
Leistungstests wie < 0,001), Vertikalsprung (p < 0,001),
Einbein-Sprungtest (p < 0,001), Beweglichkeit (p < 0,001) und
seitlich operierten (30° und 60°) Propriozeptionstests (p
< 0) beobachtet .005). Eine bessere Steigerung der exzentrischen Kraft
(p > 0,005), eine Steigerung der Ausdauerkraft um 180°/s
(p > 0,005) und eine bessere Flexibilität (p > 0,005)
traten jedoch bei den Quadrizeps- und Oberschenkelmuskeln nicht besser auf als
in der Kontrollgruppe.
Schlussfolgerungen Aufgrund dieser Ergebnisse geht man davon aus, dass
HIIT zu aktuellen Physiotherapieprogrammen hinzugefügt werden kann, da
es zu positiven Verbesserungen der Körperzusammensetzung, der
Wiederherstellung der Muskelkraft, der operierten seitlichen Propriozeption und
der Steigerung der Leistungsparameter führt, ohne die
Knielaxität nach einer ACL-Rekonstruktion zu erhöhen.
The effectiveness of child and adolescent sports engagement in China: an analysis of China’s results for the 2016–2022 Global Matrix report cards on physical activity
Authors: Xiang Changqing , Zhao Jie , Tengku Kamalden Tengku Fadilah , Dong Wenting , Luo Hua , Ismail Normala 
Published: December 2023

AbstractChina strives to become a leading sports nation. Through implemented policies and programs, Chinese children and adolescents have shown notable advancements and improvements in their engagement in physical activity in recent years, indicating an overall positive trend. However, some indicators exhibit a concerning “inversion phenomenon”. This study utilizes data from three surveys conducted between 2016 and 2022 by the Active Healthy Kids Global Alliance. By comparing current ratings with those from 2016 and 2018, both cross-sectionally and longitudinally, significant obstacles in promoting physical activity and health among Chinese children and adolescents are revealed, with persistently low scores. The 2022 Global Matrix 4.0 report ranks Chinese children and adolescents 53rd out of 57 surveyed countries, with an overall average physical activity score of D. Similarly, the average score for sources of influence ranks at 53rd. Consequently, the establishment of an integrated school, family, and social sports promotion mechanism, led by the government, becomes an imperative prerequisite for enhancing the levels of physical activity and overall health among children and adolescents.
Passive shimming for the 9.4 T whole-body MRI superconducting magnet
Authors: Wang Wenchen , Qu Hongyi , Wang Yaohui , Wang Hui , Cheng Junsheng , Wang Cong , Wu Huafang , Liu Feng 
Published: December 2023

A superconducting magnet with a warm-bore size of 800 mm and a center magnetic field of 9.4 T for the whole-body magnetic resonance imaging (MRI) system was developed in IEECAS, China. To achieve a highly homogeneous magnetic field over the 400 mm diameter of spherical volume (DSV), both active shimming and passive shimming techniques were employed. This paper mainly focuses on the implementation of passive shimming for the 9.4 T MRI magnet system. After four iterations, we were able to achieve peak-to-peak and root mean square field homogeneities over the DSV at 3.05 and 0.94 ppm, respectively. In addition, this paper analyzes the electromagnetic forces and system errors of passive shimming for ultra-high fields, providing valuable insights into MRI magnet engineering.
Event plurality and the verbal suffix ‑(a)bad in Australian Kriol
Authors: Brown Connor , Ponsonnet Maïa 
Published: December 2023

Abstract
The verbal suffix ‑(a)bad is a frequent form in Australian Kriol and is well attested across all
described varieties of the language. Despite the prevalence of this suffix, its precise semantics have so far gone undescribed in
the literature. In this article, we present a semantic analysis of this suffix, drawing on data from a variety of Kriol spoken in
the north-east Kimberley region of Western Australia. We argue that the diverse set of readings associated with
‑(a)bad can be best unified under an analysis of this form as a marker of verbal plurality (i.e.
pluractionality). The suffix derives a set of plural events from a modified verb stem, which then interacts with aspect and
argument structure to produce a wide range of readings, particularly readings of temporal, participant, and spatial plurality.