bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of bone turnover markers and DXA parameters to predict bone metastasis progression during zoledronate treatment: a single-center experience
Authors: D’Oronzo Stella , Cives Mauro , Lauricella Eleonora , Stucci Stefania , Centonza Antonella , Gentile Marica , Ostuni Carmela , Porta Camillo 
Published: January 2024

AbstractBone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover markers (BTM) with dual-energy X-ray absorptiometry (DXA) assessment could identify early BM progression and risk of skeletal-related events (SREs) during zoledronate treatment. Before the initiation of zoledronate (T0) and after six months of treatment (T1), serum levels of five BTM were measured, and patients (N = 47) underwent DXA evaluation. Standard radiological imaging was performed to assess bone tumor response to medical anti-cancer treatment. High tumor burden in bone correlated with higher serum CTX (p = 0.007) and NTX (p = 0.005) at baseline. Low concentrations of OPG at T0 predicted BM progression with a sensitivity and specificity of 63% and 77%, respectively, when a cutoff of 5.2 pmol/l was used; such a predictive meaning was stronger in patients with lytic BM (sensitivity: 88%, specificity: 80%; p = 0.0006). As for the risk of SREs, we observed an association between low baseline OC (p = 0.04) and OPG (p = 0.08) and the onset of any-time SREs, whereas an increase in OPG over time was associated with reduced risk of on-study events (p = 0.03). Moreover, a statistically significant correlation emerged between low baseline lumbar T-score and femur BMD and on-study SREs (p < 0.001 in both instances). These findings suggest that addition of DXA to BTM dosage could help stratifying the risk of SREs at the time of BM diagnosis but does not enhance our capability of detecting bone progression, during zoledronate treatment.
Density-dependent dinner: Wild boar overuse agricultural land at high densities
Authors: Augustsson Evelina , Kim Hyeyoung , Andrén Henrik , Graf Lukas , Kjellander Petter , Widgren Stefan , Månsson Johan , Malmsten Jonas , Thurfjell Henrik 
Published: January 2024

AbstractThe Swedish wild boar (Sus scrofa) population has increased rapidly over the last decades, resulting in conflicts with human activities. Particularly, the increase has been challenging for agriculture as wild boar cause damage on crops and grasslands. To predict under what conditions to expect damage and where to prioritize management actions, basic knowledge about wild boar habitat and space use is needed. In this study, we used data from 99 wild boar equipped with GPS-collars, collected over a large temporal scale and throughout their distributional range in southern Sweden. We investigated wild boar home range size and habitat use across gradients of habitat availability and population density. Functional response in habitat use was assessed by estimating the use and availability of agricultural land on individual level and then, on population-level evaluating how use changed with changing availability. Finally, a potential response in habitat use was evaluated in relation to population density, i.e., the interaction between availability and population density. Home range size was negatively related to population density for both male and female wild boar. Wild boar used agricultural land more intensively with increasing population density and when other habitat types were less available. Our findings show that wild boar spatial behavior is highly context dependent and may vary considerably due to landscape characteristics and local conditions. Wild boars tend to overuse agricultural land at high densities which has strong implications for wildlife management. It is therefore important to consider local conditions when predicting space and habitat use by wild boar. Overall, this study provided a better understanding of the drivers of wild boar distribution and space use in agro-forested mosaic landscapes and how this knowledge can improve management practices.
Investigation of Head Kinematics and Brain Strain Response During Soccer Heading Using a Custom-Fit Instrumented Mouthguard
Authors: Barnes-Wood M. , McCloskey H. , Connelly S. , Gilchrist M. D. , Annaidh A. Ni , Theobald P. S. 
Published: January 2024

AbstractAssociation football, also known as soccer in some regions, is unique in encouraging its participants to intentionally use their head to gain a competitive advantage, including scoring a goal. Repetitive head impacts are now being increasingly linked to an inflated risk of developing long-term neurodegenerative disease. This study investigated the effect of heading passes from different distances, using head acceleration data and finite element modelling to estimate brain injury risk. Seven university-level participants wore a custom-fitted instrumented mouthguard to capture linear and angular acceleration-time data. They performed 10 headers within a laboratory environment, from a combination of short, medium, and long passes. Kinematic data was then used to calculate peak linear acceleration, peak angular velocity, and peak angular acceleration as well as two brain injury metrics: head injury criterion and rotational injury criterion. Six degrees of freedom acceleration-time data were also inputted into a widely accepted finite element brain model to estimate strain-response using mean peak strain and cumulative strain damage measure values. Five headers were considered to have a 25% concussion risk. Mean peak linear acceleration equalled 26 ± 7.9 g, mean peak angular velocity 7.20 ± 2.18 rad/s, mean peak angular acceleration 1730 ± 611 rad/s2, and 95th percentile mean peak strain 0.0962 ± 0.252. Some of these data were similar to brain injury metrics reported from American football, which supports the need for further investigation into soccer heading.
Motivations for personal recordkeeping practices: the roles of personal factors, recordkeeping literacy and the affordances of records
Authors: Frings-Hessami Viviane 
Published: January 2024

AbstractWhy do individuals create and keep records? Little research has been done into the factors that motivate individuals to make records. This article uses the example of the personal records created by Bangladeshi rural women who participated in a development project to investigate the roles that personal choices and external influences play in the development of recordkeeping practices. By conducting interviews with participants after the end of the project, the author obtained some insights into the factors that encouraged them to create records during the project and the reasons why they continued or stopped doing it after the end of the project and about the role played by external actors, in particular local staff from non-governmental organisations, in influencing their recordkeeping practices. The author shows that the participants started creating and keeping records when they understood the importance that these records could have for them in the future and that the women who persevered with personal recordkeeping practices were those who were more educated and more information literate. On the other hand, the participants who wrote down information because they were encouraged to do so stopped doing it when the regular information flow ended, and they were no longer encouraged to capture information. The author argues that the factors that encourage individuals to create and keep records differ depending on the affordances that the records provide to them. Whereas external actors can play an important role in motivating people to keep records as evidence, for records that are kept for their informational content, personal motivations and recordkeeping literacy skills play a determinant role.
Clinical impact of delaying initiation of adjuvant chemotherapy in patients with early triple negative breast cancer
Authors: Hatzipanagiotou Maria Eleni , Pigerl Miriam , Gerken Michael , Räpple Sophie , Zeltner Verena , Hetterich Madeleine , Ugocsai Peter , Inwald Elisabeth Christine , Klinkhammer-Schalke Monika , Ortmann Olaf , Seitz Stephan 
Published: January 2024

Abstract
Purpose
The optimal time to initiation of adjuvant chemotherapy (TTAC) for triple negative breast cancer (TNBC) patients is unclear. This study evaluates the association between TTAC and survival in TNBC patients.

Methods
We conducted a retrospective study using data from a cohort of TNBC patients diagnosed between January 1, 2010 to December 31, 2018, registered in the Tumor Centre Regensburg was conducted. Data included demographics, pathology, treatment, recurrence and survival. TTAC was defined as days from primary surgery to first dose of adjuvant chemotherapy. The Kaplan–Meier method was used to evaluate impact of TTAC on overall survival (OS) and 5-year OS.

Results
A total of 245 TNBC patients treated with adjuvant chemotherapy and valid TTAC data were included. Median TTAC was 29 days. The group receiving systemic therapy within 22 to 28 days after surgery had the most favorable outcome, with median OS of 10.2 years. Groups receiving systemic therapy between 29–35 days, 36–42 days, and more than 6 weeks after surgery had significantly decreased median survival, with median OS of 8.3 years, 7.8 years, and 6.9 years, respectively. Patients receiving therapy between 22–28 days had significantly better survival compared to those receiving therapy between 29–35 days (p = 0.043), and patients receiving therapy after 22–28 days also demonstrated significantly better survival compared to those receiving therapy after more than 43 days (p = 0.033).

Conclusion
Timing of adjuvant systemic therapy can influence OS in TNBC patients. Efforts should be made to avoid unnecessary delays in administering chemotherapy to ensure timely initiation of systemic therapy and optimize patient outcomes.
Suspension, Entailment, and Presupposition
Authors: Rosa Luis 
Published: January 2024

AbstractThe paper is concerned with the rational requirements for suspended judgment, or what suspending judgment about a question rationally commits one to. It shows that two purported rational requirements for suspended judgment cannot both be true at the same time, at least when the entailment relation between questions is understood a certain way. The first one says that one is rationally required to suspend judgment about those questions that are entailed by the questions that one already suspends judgment about. The second one says that one is rationally required to believe the presuppositions of the questions one suspends judgment about. Two plausible solutions to the problem are discussed. One of them explicates the relation of entailment between questions in an alternative manner, and the other one rejects the presupposition requirement. Either way, a closure requirement for suspended judgment can be maintained which is analogous to the closure requirement for belief. Whereas belief is ideally closed under entailment between propositions, suspended judgment is ideally closed under entailment between questions.
Interspecific competitive interactions affect body size and oxidative status of two nonnative salmonid species
Authors: Parolini Marco , Iacobuzio Rocco , Bassano Bruno , Pennati Roberta 
Published: January 2024

AbstractIn fish, interspecific interactions between nonnative and other sympatric species are considered determinants in shaping species assemblages. Such interactions can also arise between nonnative fish species only, including salmonids such as the brown trout (Salmo trutta, Linnaeus, 1758) and the rainbow trout (Oncorhynchus mykiss, Walbaum, 1792), returning contrasting outcomes. The present manipulative experiment was aimed at exploring the effect of interspecific competition on the body growth and the oxidative status of parr (2 + -year-old individuals) of the brown trout and the rainbow trout. Allopatric (intraspecific competition) and sympatric (interspecific competition) populations of these species were experimentally recreated in two wild streams. At the end of a 2-month-long experiment, changes in specific growth rate (SGR), oxidative status (i.e., levels of reactive oxygen species and activity of antioxidant enzymes such as superoxide dismutase — SOD, catalase — CAT and glutathione peroxidase — GPx) and oxidative damage (i.e., lipid peroxidation) were investigated in brown and rainbow trout individuals maintained in allopatric or sympatric populations. Sympatric interactions between rainbow and brown trout parr resulted in a significant decrease in SGR of brown trout individuals only. Moreover, an overall modulation of the oxidative status, in terms of an increase in ROS levels coupled with the activation of SOD and CAT activity, occurred in brown trout individuals under sympatric conditions. These findings might suggest that, under sympatric conditions, parr of the rainbow trout are more competitive than brown trout for food acquisition. However, this competition affected the antioxidant defenses of the brown trout only, probably because of reduced ingestion of dietary antioxidants or increased physical activity and aggressive behavior. Thus, interspecific interactions can induce physiological and phenotypic effects on parr of nonnative salmonids, with potential consequences on the establishment of populations of these species in freshwater ecosystems.
The Lifeworld of the Complex Care Hospital Doctor: A Complex Adaptive Phenomenological Study
Authors: Borghmans Felice , Laletas Stella , Newnham Harvey , Fernandes Venesser 
Published: January 2024

AbstractThe ever-increasing prevalence of chronic conditions over the last half century has gradually altered the demographic of patients admitted to acute care settings; environments traditionally associated with episodic care rather than chronic and complex healthcare. In consequence, the lifeworld of the hospital medical doctor often entails healthcare for a complex, multi-morbid, patient cohort. This paper examines the experience of providing complex healthcare in the pressurised and fast-paced acute care setting. Four medical doctors from two metropolitan health services were interviewed and their data were analysed using a combinatorial framework of phenomenology and complexity theory. The horizon of complex care revealed itself as dynamic, expansive, immersive, and relational, entailing a specialised kind of practice that is now common in acute care settings. Yet this practice has made inroads largely without heralding the unique nature and potential of its ground. Herein lies opportunity for complex care clinicians to expand notions of health and illness, and to shape research, practice, and system design, for a future in which care for health complexity is optimised, irrespective of care settings.
Cryogenic Resonant Amplifier for Electron-on-Helium Image Charge Readout
Authors: Belianchikov Mikhail , Kraus Jakob A. , Konstantinov Denis 
Published: January 2024

AbstractAn electron-on-helium qubit is a promising physical platform for quantum information technologies. Among all the “blueprints” for the qubit realization, a hybrid Rydberg-spin qubit seems to be a promising one toward quantum computing using electron spins. The main technological challenge on the way to such qubits is a detection of fA range image current induced by a Rydberg transition of a single electron. To address this problem, we aim to use a tank LC-circuit in conjunction with a high-impedance and low power dissipation cryogenic amplifier. Here, we report our progress toward realization of a resonant image current detector with a homemade cryogenic amplifier based on FHX13LG HEMT. We present a detailed characterization of the transistor at room and cryogenic temperatures, as well as details of the amplifier design and performance. At the power dissipation level of amplifier well below 100 μW, the measured voltage and current noise level are $$0.6~{\hbox {nV}}/\sqrt{\textrm{Hz}}$$

0.6

nV
/

Hz

and below 1.5 fA/$$\sqrt{\textrm{Hz}}$$

Hz

, respectively. Based on the actual image current measurements of the Rydberg transition in a many-electron system on liquid helium, we estimate an SNR = 8 with a measurement bandwidth 1 Hz for the detection of a single-electron transition, providing the noise level at the output is solely determined by the noise of the amplifier.
Development of a novel testing concept for combined characterisation of tensile and compressive properties
Authors: Bensing Timo , Moneke Martin 
Published: January 2024

AbstractA novel material testing concept is developed in order to provide tensile and compressive properties within a single mechanical test. A new specimen geometry is designed for testing in a universal testing machine. Under tensile load, both a homogeneous tensile stress condition as well as a homogeneous compressive stress condition occur in the specimen. Measurements accompanying the experimental test with digital image correlation provide tensile and compressive Poisson’s ratio as well as tensile modulus. These properties are input parameters for subsequent finite element simulations. The compressive modulus is determined by iteratively adjusting finite element simulations in order to couple experimental and simulated results. For validating the concept, experimental tests are carried out on polyoxymethylene. While the tensile Poisson’s ratio of the new concept shows the best agreement with the reference value, the compressive modulus is approximately 15% higher. Further work should focus on an appropriate material model in order to reduce the deviation.
Economic benefits of climate-smart agricultural practices: empirical investigations and policy implications
Authors: Sang Xiance , Chen Chen , Hu Die , Rahut Dil Bahadur 
Published: January 2024

AbstractAdopting climate-smart agricultural practices (CAPs) has the potential to mitigate the adverse effects of climate change and directly influence the well-being of households. Therefore, this research investigates the impact of CAP adoption intensity on household income, net farm income, and income diversity, using the 2020 China Rural Revitalization Survey data. We utilize the approach of two-stage residual inclusion (2SRI) to mitigate the endogeneity of CAP adoption intensity. The results show that CAP adoption intensity positively and significantly affects household income, net farm income, and income diversity. Heterogeneous analysis indicates that the impacts of CAP adoption intensity on household income increase across the selected quantiles, but the impacts on net farm income decrease across the same. In addition, CAP adoption intensity significantly improves income diversity only at the 20th quantile. Our findings suggest that enhancing farmers’ CAP adoption intensity improves rural household welfare.
Parametric reduced-order modeling for component-oriented treatment and localized nonlinear feature inclusion
Authors: Vlachas Konstantinos , Garland Anthony , Quinn D.Dane , Chatzi Eleni 
Published: January 2024

AbstractWe propose coupling a physics-based reduction framework with a suited response decomposition technique to derive a component-oriented reduction (COR) approach, which is suitable for assembly systems featuring localized nonlinearities. Dependencies on influencing parameters are injected into the reduced-order model (ROM), thus ensuring robustness and validity over a domain of parametric inputs, while capturing nonlinear effects. The implemented approach employs individual component modes to capture localized features while additionally relying on reduced modes of a global nature to approximate the system’s dynamics accurately. The global modes are derived from a linear monolithic system, defined as a result of a coordinate separation scheme, which permits the proposed COR-ROM to naturally couple the response between linear and nonlinear subdomains. The derived low-order representation utilizes a proper orthogonal decomposition projection and is additionally reinforced with the inclusion of a hyper-reduction technique to capture the underlying high-fidelity model response while providing accelerated computations. The resulting approach is exemplified in the synthetic case studies of a four-story shear frame with multiple nonlinear regions driven by hysteresis and a large-scale kingpin connection featuring plasticity.
Magnetic Reconnection at Planetary Bodies and Astrospheres
Authors: Gershman Daniel J. , Fuselier Stephen A. , Cohen Ian J. , Turner Drew L. , Liu Yi-Hsin , Chen Li-Jen , Phan Tai D. , Stawarz Julia E. , DiBraccio Gina A. , Masters Adam , Ebert Robert W. , Sun Weijie , Harada Yuki , Swisdak Marc 
Published: January 2024

AbstractMagnetic reconnection is a fundamental mechanism for the transport of mass and energy in planetary magnetospheres and astrospheres. While the process of reconnection is itself ubiquitous across a multitude of systems, the techniques used for its analysis can vary across scientific disciplines. Here we frame the latest understanding of reconnection theory by missions such as NASA’s Magnetospheric Multiscale (MMS) mission for use throughout the solar system and beyond. We discuss how reconnection can couple magnetized obstacles to both sub- and super-magnetosonic upstream flows. In addition, we address the need to model sheath plasmas and field-line draping around an obstacle to accurately parameterize the possibility for reconnection to occur. We conclude with a discussion of how reconnection energy conversion rates scale throughout the solar system. The results presented are not only applicable to within our solar system but also to astrospheres and exoplanets, such as the first recently detected exoplanet magnetosphere of HAT-11-1b.
Aristotelian universals, strong immanence, and construction
Authors: Costa Damiano , Giordani Alessandro 
Published: January 2024

AbstractThe Aristotelian view of universals, according to which each universal generically depends for its existence on its instantiations, has recently come under attack by a series of ground-theoretic arguments. The last such arguments, presented by Raven, promises to offer several significant improvements over its predecessors, such as avoiding commitment to the transitivity of ground and offering new reasons for the metaphysical priority of universals over their instantiations. In this paper, we argue that Raven's argument does not effectively avoid said commitment and that Raven's new reasons fail. Moreover, we present a novel ground-theoretic interpretation of the Aristotelian view, referred to as strong immanence, and introduce a new argument against the Aristotelian view, intended to sidestep any commitment to the transitivity of ground.