bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Alternatives to Non-biodegradable Polymers in 3D Printing of
Pharmaceuticals
Authors: Somwanshi Ayush , Wadhwa Pankaj , Raza Amir , Hudda Sharwan , Magan Muskan , Khera Kanav 
Published: October 2023

Background:
Due to potential toxicity, non-biodegradable polymers used in 3D (3-dimensional)
printing of drugs could be dangerous for patient safety and the environment.

Objective:
This review aims to investigate the toxicity of non-biodegradable polymers and investigate the use
of natural materials as an alternative in 3D printing medicines. The study evaluates the dangers connected to
3D printing.

Methods:
A review of the literature on various 3D printing processes, such as inkjet printing, fused filament
manufacturing, and extrusion-related 3DP systems, was done for this study. Also, the use of cellulose derivatives
and natural materials in 3D printing and their potential as active excipients was proposed.

Results:
The review identified potential toxicity risks linked to non-biodegradable polymers used in drug 3D
printing. As a potential fix for this issue, the use of natural materials with improved mechanical and thermal
properties was explored. The use of cellulose derivatives as an alternative to non-biodegradable polymers in
3D printing pharmaceuticals was also investigated in the study.

Conclusion:
This study emphasises the significance of evaluating the risks connected to drug 3D printing and
recommends using natural materials as an alternative to non-biodegradable polymers. More study is required
to create secure and reliable 3D printing processes for pharmaceuticals.
Research Progress on Immunomodulatory Effects of Poly (Lactic-co-
Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine
Monomers
Authors: Song Bocui , Chen Qian , Tong Chunyu , Li Yuqi , Li Shuang , Shen Xue , Niu Wenqi , Hao Meihan , Ma Yunfei , Wang Yanhong 
Published: October 2023

Abstract:
Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance
of the environment in humans. When the immune function of the immune system is impaired,
autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition,
genetic factors and other reasons cause low immune function, due to which the body is prone to being
infected by bacteria or cancer. Clinically, the existing therapeutic drugs still have problems such
as high toxicity, long treatment cycle, drug resistance and high price, so we still need to explore and
develop a high efficiency and low toxicity drug. Poly(lactic-co-glycolic acid) (PLGA) refers to a nontoxic
polymer compound that exhibits excellent biocompatibility. Traditional Chinese medicine
(TCM) monomers come from natural plants, and have the characteristics of high efficiency and low
toxicity. Applying PLGA to TCM monomers can make up for the defects of traditional dosage forms,
improve bioavailability, reduce the frequency and dosage of drug use, and reduce toxicity and side
effects, thus having the characteristics of sustained release and targeting. Accordingly, PLGA nanoparticles
loaded with TCM monomers have been the focus of development. The previous research on
drug loading advantages, preparation methods, and immune regulation of TCM PLGA nanoparticles
is summarized in the following sections.
Gamma Secretase as an Important Drug Target for Management of
Alzheimer’s Disease: A Comprehensive Review
Authors: Tadros Hakem Fady , Farid Fouad Youstina , Arafa Reem K. 
Published: October 2023

Abstract:
Alzheimer’s disease (AD) is a neurological disease that affects the memory. AD has
been attributed to the aggregations of amyloid-β (Aβ) peptides which result in the formation of
plaques that block the neuron-transferring process done by the brain memory cells. These plaques
are formed upon cleavage of Amyloid Precursor Protein (APP) by Gamma-Secretase (GS). GS
protein has around 141 substrates, the important two are APP and Notch. Considering one of the
hot spots in AD research, we focused on GS and its relation to AD. Moreover, a lot of research
was done on beta-secretase and drugs were developed to target it however, few drugs are established
for GS. GS contains four subunits: Presenilin (PS), PEN-2, Nicastrin, and APH-1. The catalytic
subunit is PS, which contains the active site for substrate binding, as well as the allosteric
and docking sites. Both PEN-2 and APH-1 are regulators for the stability and activity of GS. Nicastrin,
helps the substrates bind to the PS. Additionally, the role of the immuno-protein named
“IFITM3” and how it affects the immune system and its relation to AD is presented. GS is one of
the most studied proteins with many developed candidates as inhibitors (GSI) and modulators (GSM).
Examples of GSI are Semagacestat and Avagacestat while GSM includes E2012; which inhibits
the cleavage activity of GS. In this report, each of the four subunits of GS is described in detail,
along with the interactions between GS and its inhibitors or modulators. In addition, the
FDA-approved drugs are enlisted.
Identification of Potential Lead Compounds against BCL-2 through
In-silico Screening of Phytochemicals of Nigella sativa and Cuscuta reflexa
for Oral Squamous Cell Carcinoma Management
Authors: Begum N. Fazulunisa , Ramani Pratibha , Doble Mukesh , Ramasubramanian Abilasha 
Published: October 2023

Significance of the study:
In silico analysis is frequently used in physicochemical characterisation,
the discovery and improvement of novel compounds with affinity to a target, and the elucidation
of absorption, distribution, metabolism, excretion, and toxicity features.

Aim and Objective:
The aim of this study is to assess the efficacy of Nigella sativa and Cuscuta reflexa
in targeting Bcl2-antiapoptotic protein in Oral Squamous Cell Carcinoma through in silico analysis.

Materials and Methods:
The present study was designed to formulate a drug against Oral Squamous
cell carcinoma against the target protein Bcl-2. Protein Database (PDB) was used to select and analyse
the protein. Based on the literature search, the original molecules selected were thymoquinone,
tannin pyrogallol, Cuscutin, kaempferol, nigellicine and the ligand structures were obtained ZINC15
database. Target protein structure was recognised through Protein sequence from PB (Protein Data
Bank). Swiss ADME was used for assessing the properties of the molecules. Twenty new molecules
were identified from zinc pharmer and docking was done for all the 20 using Swiss dock. Binding
energy was assessed and compared with the original molecules.ZINC73690300 and ZINC73690304 had better binding energy than that of original molecules. Both molecules can be potential candidates for Bcl2 inhibition to prevent OSCC.

Results:
ZINC73690300 and ZINC73690304 had better binding energy than that of the original molecules.
Both molecules can be potential candidates for Bcl-2 inhibition to prevent OSCC.

Conclusion:
The present study evaluated the binding energy and bioavailability of the combined extract,
thus attempting to predict the target ligand binding between the compounds in OSCC before
attempting in vitro studies.-
A Comprehensive Review of Preclinical Models for Polycystic Ovary
Syndrome
Authors: Kumar G. Santhana , Garg Kritika , Soni Arun , Dalal Mittal 
Published: October 2023

Background:
Polycystic ovary syndrome (PCOS) is a reproductive, metabolic, and endocrine
disorder with unclear aetiology. PCOS, the most common cause of female reproductive and
metabolic disorders, is known to affect more than one in ten women globally. PCOS and associated
clinical manifestations are probably underdiagnosed despite their high occurrence.

Objective:
Alternative animal models have been employed to investigate the causes of PCOS or
assess potential treatments. In light of this piece of information, it is challenging to create an animal
model that accurately captures all components of this condition; nonetheless, the resemblance of an
animal model's biology and/or biochemical characteristics to the phenotypes of PCOS in humans
may boost its applicability.

Result:
The key characteristics of these models are closer to human situations when compared to
women with PCOS, as shown by this comparison. The creation and testing of drugs for the treatment
of PCOS are necessary.

Conclusion::
The overview of PCOS, current preclinical models, and appropriate models chosen in
different studies to mimic various phenotypes in PCOS studies are all covered in this review paper.
Additionally, we have outlined the benefits and drawbacks of PCOS animal models.
Latent Mastocytosis Triggered by COVID-19 Vaccination: A Case Report
Authors: Calogiuri Gianfranco , Foti Caterina , Congedo Maurizio , Nettis Eustachio , Paladini Luigi , Greco Giuseppina , Pavone Vincenzo , Vacca Angelo 
Published: October 2023

Background:
Hereby, we describe the first case of latent mastocytosis triggered by
mRNA-based vaccine to prevent COVID-19 infection.

Case Presentation:
In a 42-year-old Arabian man affected by slight, undiagnosed mastocytosis,
the second dose of the COVID-19 vaccine made more blatant his latent disease. The postvaccination
diagnostic iter is illustrated and the potential reasons causing the onset of the cutaneous
mastocytosis are discussed.

Conclusion:
Clinicians should keep a longer follow-up of their patients after the COVID-19
vaccination, not related to few hours, for the risk of immediate-type adverse events only.
Lipid-based Nanoparticles (LNP) Structures used for Drug Delivery and
Targeting: Clinical Trials and Patents
Authors: Amarachi Chime Salome , Attama Anthony A. 
Published: October 2023

Abstract:
Lipid based nanoparticle (LNP) structures commonly used for drug delivery already in clinical
use are generally classified into three viz vesicular systems, emulsion based systems and lipid
nanoparticles. The details of the types, basic structural characteristics in drug delivery, clinical trials,
and patents have been discussed in this work. Moreover, despite the therapeutic efficacies of LNPs,
there are some toxicity challenges associated with their use. These toxicities may be cytotoxicity or
genotoxicity; to overcome some of these challenges, some measures could be taken during preformulation
stages in order to circumvent it. These measures have been extensively discussed in this work.
LNPs are used in the targeting of immune cells, which are direct participants in a variety of diseases,
hence, are attractive targets for therapy. Cell specific targeting of therapeutic agent(s) helps to concentrate
and localize the therapeutic effect and, hence, lowers the systemic side effects, while simultaneously
increasing the management outcome. Nanotechnology and particle engineering helps distinguish
each immune cell from the other to deliver therapeutic agents and ensure in vivo stability as well as
sustained drug release. Surface modification of LNP is an important characteristic utilized in targeting
therapeutic agents and allows the utilization of various specific properties expressed in each immune
cell. These targeting strategies have been explored in this work exhaustively, and some of the companies
and academic labs that develop LNP have been discussed. Also, new ways of developing novel
patentable LNP have been discussed.
Yoga and Meditation in the Treatment of Neurological and Psychiatric Disorders
Authors: Ghosh Dastidar Debabrata , Bhattacharjee Payel , Das Pratyush , Jana Bachaspati , Bhunia Anirban 
Published: October 2023

Background::
According to the Global Burden of Disease (GBD) study, the global
health impact of neurological and psychiatric disorders has been underestimated for years. Neuropsychiatric
disorders are now recognised as significant threats to public health. In conjunction
with modern pharmaceutical interventions, the clinical application of yoga and meditation techniques
has been increasingly recognised for their efficacy in treating various mental health conditions.

Objective::
This article aimed to provide a comprehensive review summarizing the influence of
yoga and meditation on the human brain, specifically focusing on their clinical implementation
for neurological and psychiatric disorders.

Methods::
A systematic search was conducted across PubMed and Google Scholar databases utilizing
diverse combinations of keywords, including yoga, meditation, neurogenesis, neurological
disorder, mental health, mindfulness, thought process, neuroimaging, and brain, to identify pertinent
literature for this review.

Results::
Prevalent neurological and psychiatric ailments in our society encompass multiple sclerosis,
epilepsy, migraine, fibromyalgia, cerebrovascular disease, Alzheimer's disease, major depression,
anxiety disorder, and chronic stress. Scientifically corroborated by clinical studies, the
advantageous effects of yoga and spiritual practices on these disorders have been substantiated.
As our understanding of the complex psychology and functionalities of the human brain progresses,
it becomes apparent that yoga and meditation facilitate neurogenesis and restore chemical
equilibrium. Such practices aid in dispelling intrusive thoughts, negating negative emotions,
and ameliorating stress, thereby offering relief to patients and progressively diminishing their
reliance on conventional medication.

Conclusion::
The integration of yoga and spiritual practices as complementary and non-invasive
adjunctive therapies represents a promising approach to addressing the spectrum of neurological
disorders plaguing modern society.
Ganoderma lucidum, a Potential Revolutionary Macro Fungus in the Field of Medicine
Authors: Rani Isha , Gupta Mehak , Sharma Samarth , Kaur Dr. Gagandeep , Sharma Pankaj 
Published: October 2023

Abstract::
Ganoderma lucidum is a traditional Asian medication used in China, Korea, and Japan.
It is a well-known medicinal fungus that is regarded as the elixir of life. Polysaccharides,
proteins, enzymes, sterols, fatty acids, vitamins, minerals, and peptides are some of the 400
physiologically active substances. Anti-inflammatory, anti-ulcer, anti-diabetic, antiandrogenic,
anti-aging, anti-fibrotic, antioxidant, hepatoprotective, sleep-promoting, anticarcinogenic, chemo
and radioprotective, immunomodulation, estrogenic, and antibacterial properties are just a few of
the numerous reported pharmacological effects. This review will help us to examine the role that
this macro fungus holds in various therapeutic applications and how it can be a significant influence
in the field of medicine.
Detección de Vapor de Etanol por modificación de la conductividad eléctrica del Dióxido de Estaño
Authors: Huamán Fernando , Reyes Luis , Estrada Walter , Gutarra Abel 
Published: October 2023

Se han fabricado, por el método de sinterizado, recubrimientos de oxido de estaño para detección de vapor de etanol.
Después de un tratamiento térmico adecuado, se obtuvieron partículas de un bajo nivel de coalescencia. La detección de vapor se basa en los cambios de resistencia superficial del recubrimiento debido a la presencia de etanol. Para explicar este comportamiento se utilizó un modelo teórico simplificado basado en la adsorción superficial de moléculas ionizadas.
Nuestros datos experimentales se ajustan muy bien dentro del rango de 10-130ug/ml. Para la concentración de vapor en aire encontramos el vapor experimental de m=0.63 en la ecuación de conductancia dada por G=G0 [v]m
Structural Equation Model for Social Support and Quality of Life Among Individuals With Mental Health Disorders During the COVID-19 Pandemic
Authors: Tran Bach Xuan , Dam Vu Anh Trong , Auquier Pascal , Boyer Laurent , Fond Guillaume , Nguyen Hung Manh , Nguyen Hung Tuan , Le Huong Thi , Tran Ha Nhi Thi , Vu Giang Thu , Nguyen Manh Duc , Nguyen Duong Anh Thi , Ly Bang Viet , Latkin Carl A , Zhang Melvyn WB , Ho Roger CM , Ho Cyrus SH 
Published: October 2023

Background
In light of the COVID-19 pandemic, the distribution of social support for mental health problems has likely become unequal. Family- and community-based social support has been recognized as a promising approach for mental disorders; however, limited global frameworks have been applied to developing countries such as Vietnam.

Objective
The aim of this study was to evaluate the quality of life and social support among patients with mental health disorders in Vietnam and to investigate the factors associated with quality of life among these patients.

Methods
A cross-sectional study was conducted on 222 psychiatric patients in Hanoi from 2020 to 2022. A structured questionnaire was developed based on four standardized scales: Mental Well-Being-5 scale, Multidimensional Scale of Perceived Social Support, EuroQoL-visual analog scale (EQ-VAS), and EuroQoL-5 dimensions-5 levels (EQ-5D-5L) scale. Tobit regression was used to identify factors associated with the EQ-5D-5L and EQ-VAS scores. Structural equation modeling was applied to verify the relationship between quality of life and social support.

Results
The results showed that perceived support from family scored the highest compared to support from friends and significant others. Patients with depression reported the lowest quality of life and perceived social support. Structural equation modeling showed a root mean square error of approximation of 0.055 (90% CI 0.006-0.090), comparative fit index of 0.954, Tucker-Lewis index of 0.892, and standardized root mean squared error of 0.036 (P<.001). The hypothetical model indicated statistically significant correlations between EQ-VAS score and social support (P=.004), EQ-5D-5L and mental well-being (P<.001), and social support and mental well-being (P<.001). Critical deterioration of quality of life and inconsistency in social support for patients with mental illness were also recorded.

Conclusions
There is a need to enhance social support and service delivery in Vietnam, focusing on occupation and quality of life. The correlations between social support, quality of life, and mental health issues suggest the potential of a clinical-social integrated intervention model of care.
Investigating Topical Steroid Withdrawal Videos on TikTok: Cross-Sectional Analysis of the Top 100 Videos
Authors: Haddad Firas , Abou Shahla William , Saade Dana 
Published: October 2023

Background
Social media platforms like TikTok are a very popular source of information, especially for skin diseases. Topical steroid withdrawal (TSW) is a condition that is yet to be fully defined and understood. This did not stop the hashtag #topicalsteroidwithdrawal from amassing more than 600 million views on TikTok. It is of utmost importance to assess the quality and content of TikTok videos on TSW to prevent the spread of misinformation.

Objective
This study aims to assess the quality and content of the top 100 videos dedicated to the topic of TSW on TikTok.

Methods
This observational study assesses the content and quality of the top 100 videos about TSW on TikTok. A total of 3 independent scoring systems: DISCERN, Journal of the American Medical Association, and Global Quality Scale were used to assess the video quality. The content of the videos was coded by 2 reviewers and analyzed for recurrent themes and topics.

Results
This study found that only 10.0% (n=10) of the videos clearly defined what TSW is. Videos were predominantly posted by White, middle-aged, and female creators. Neither cause nor mechanism of the disease were described in the videos. The symptoms suggested itching, peeling, and dryness which resembled the symptoms of atopic dermatitis. The videos fail to mention important information regarding the use of steroids such as the reason it was initially prescribed, the name of the drug, concentration, mechanism of usage, and method of discontinuation. Management techniques varied from hydration methods approved for treatment of atopic dermatitis to treatment options without scientific evidence. Overall, the videos had immense reach with over 200 million views, 45 million likes, 90,000 comments, and 100,000 shares. Video quality was poor with an average DISCERN score of 1.63 (SD 0.56)/5. Video length, total view count, and views/day were all associated with increased quality, indicating that patients were interacting more with higher quality videos. However, videos were created exclusively by personal accounts, highlighting the absence of dermatologists on the platform to discuss this topic.

Conclusions
The videos posted on TikTok are of low quality and lack pertinent information. The content is varied and not consistent. Health care professionals, including dermatologists and residents in the field, need to be more active on the topic, to spread proper information and prevent an increase in steroid phobia. Health care professionals are encouraged to ride the wave and produce high-quality videos discussing what is known about TSW to avoid the spread of misinformation.
Kualitas Donat Berbahan Campuran Tepung Biji Bunga Matahari
Authors: Suda I Made Hendry Dwi Wira , Widhyandanta I Gede Dirga Surya Arya 
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengetahui kualitas dari donat berbahan campuran tepung biji bunga matahari yang dinilai dari kualitas rasa, aroma, tekstur, dan tampilan sehingga masyarakat dapat memanfaatkan biji bunga matahari agar bisa dijadikan inovasi terbaru yang dinilai dari segi rasa, aroma, tekstur, tampilan, daya tahan, biaya produksi dan hasil minat konsumen pada donat berbahan campuran tepung biji bunga matahari. Penelitian ini menggunakan teknik analisis data deskriptif berbasis organoleptic dimana melakukan proses percobaan atau trial terlebih dahulu agar menghasilkan sebuah produk yang layak dikonsumsi masyarakat, lalu membagikan kuisioner yang dibagikan kepada 15 orang panelis yang terdiri dari staff kitchen Amnaya Resort Kuta, mahasiswa/I IPB Internasional dan masyarakat sekitar. Hasil penelitian ini menunjukan bahwa donat berbahan campuran tepung biji bunga matahari memiliki rasa yang enak, aroma cukup sedap, tekstur yang lembut dan memiliki tampilan warna yang menarik. Lalu uji daya tahan dapat disimpulkan bahwa donat berbahan campuran tepung biji bunga matahari dapat bertahan selama 2 hari di suhu ruangan. Biaya produksi dalam pembuatan donat berbahan campuran tepung biji bunga matahari ini menghabiskan biaya sebesar Rp. 79.328,- dan dari hasil kuisioner minat konsumen menunjukan bahwa 13 dari 15 partisipan berminat untuk membeli donat berbahan campuran tepung biji bunga matahari ini jika dijual di pasaran.

The purpose of this study was to determine the quality of donuts made from a mixture of sun flower seed flour assessed from the quality of taste, aroma, texture, and appearance so that people can use sunflower seeds so that they can be used as the latest innovations judged in terms of taste, aroma, texture, appearance, durability, production cost and results of consumer interest in donuts made form a mixture of sunflower seed flour. This study uses an organoleptic based descriptive data analysis technique which conducts a trial process first in order to produce a product that is suitable for public consumption, then distributes questionnaires which are distributed to 15 panelists consisting of Amnaya Resort Kuta Kitchen staff, students/I IPB International and local communities. The results of this study indicate that donuts made from a mixture of sunflower seed flour have a good taste, quite delicious aroma, soft texture and have an attractive color appearance. Then the durability test can be conclude that donuts made from mixed sunflower seed flour can last for 2 days at room temperature. The production cost in making donuts made from a mixture of sunflower seed flour cost Rp.79.328,- and the results of the consumer interest questionnaire showed that 13 out of 15 participants were interested in buying donuts made from a mixture of sunflower seed flour if they were sold in the market.