bluuebunny/crossref_metadata_2025_split huggingface dataset:
ECCO Grant Immune-epithelial crosstalk boosting intestinal repair in ulcerative colitis
Authors: Hausmann Annika 
Published: January 2024

Abstract

Background and Aims
1.3 million people in Europe suffer from inflammatory bowel disease (IBD). Its most prevalent subtype is ulcerative colitis (UC), a chronic colon inflammation of unknown etiology. The breakdown of intestinal epithelial barrier integrity is a key event initiating intestinal inflammation in UC, and remission requires epithelial repair. Repair is modulated by inflammatory signals which exert anti- but also pro-proliferative effects. It is unknown how the epithelium integrates inflammatory signals to finetune repair, limiting current therapeutic strategies in UC to symptomatic suppression of inflammation with potential detrimental effects on repair. With this project, I aim to gain a molecular understanding of immune cell-epithelial crosstalk in UC to inform targeted therapies that suppress detrimental inflammation and boost epithelial repair.

Methods
To this end, I propose a novel, interdisciplinary approach, venturing beyond traditional approaches by employing my host lab’s expertise on epithelial injury and repair in combination with my competence in mucosal immunology and a novel visual proteomics technique to decipher immune cell-epithelium crosstalk driving epithelial repair in UC. Specifically, I will generate a high-resolution proteome map of the repairing colonic mucosa of patients with UC to identify potential immune cell-epithelium crosstalk, validate candidates and assess the reparative potential of the identified crosstalk in human intestinal epithelial cells using organoid cultures.

Anticipated Impact
Current therapeutic strategies in UC, focused on immune suppression, still feature high rates of primary or secondary non-response, fueling disease progression and decreasing patient quality of life. This highlights a key unmet clinical need for alternative therapeutic approaches. I anticipate that the identified immune-mediated drivers of epithelial repair will provide novel molecular targets for future pharmacological interventions aiming to mitigate inflammation-induced epithelial barrier loss and to boost repair capacity. This will improve patient quality of life and reduce treatment costs.
N-ECCO Grant Spiritual needs of patients with inflammatory bowel disease and their caregivers: a European cross-sectional nursing study
Authors: Martinato M 
Published: January 2024

Abstract

Aims
Spirituality is the search for meaning or purpose in life (Delgado, 2005), not strictly from a religious perspective. Spiritual well-being is positively connected with physical and psychic well-being, and achieving the first is likely to help to maintain the latter (Bożek et al., 2020). Individuals with chronic disorders or experiencing a life-changing condition (e.g. Inflammatory Bowel Disease - IBD), may have gone through a spiritual quest of some sort that can produce spiritual anguish or 'spiritual distress', interpreting the disease as a punishment, feeling as a victim of 'superior injustice', losing faith in prayer (Klimasiński et al., 2022), but data on the spiritual needs (SpNs) of IBD patients are lacking.
The main objective of this project is to describe the SpNs of IBD patients to provide information to IBD nurses on how to address these needs.

Methods
A multilingual cross-sectional electronic survey will be carried on assessing the SpNs of patients using the Spiritual Needs Questionnaire (SpNQ). The tool is made up of items assessing the importance attributed by patients to SpNs using a 4-point Likert scale (Büssing et al., 2010), and is available in ten European languages, but it could be translated and validated in other European languages inside the project in case of anticipated participation by a country that need the questionnaire available in the local language if a collaboration with IBD clinicians and patients in that country will be possible.

Anticipated Impact
The findings of such a study can provide better consideration of SpNs in the treatment of IBD patients, emphasizing the importance of addressing SpNs for IBD nurses in managing IBD patients, adopting the tools to screen patients for these needs; furthermore, the results of this project can provide additional evidence of the importance of nursing in IBD patients’ care.
N-ECCO Grant Supporting psychosocial and emotional well-being and resilience in family members of people with IBD: an intervention co-design and feasibility study
Authors: Thapwong P , Norton C , Rowland E , Czuber Dochan W 
Published: January 2024

Abstract

Background and Aims
This ongoing PhD project seeks to develop a person-centred, evidence-based, theoretically informed prototype intervention to support psychosocial and emotional well-being and resilience in people with IBD’s family members (FMs). PhD project focuses on the intervention development and feasibility testing. The development phase has already been undertaken using a co-design approach informed by Design Thinking. A systematic review and qualitative research have been conducted and published, and co-design workshops have been held with people with IBD (n=4), FMs (n=9), and IBD nurses (n=2), revealing a preference for online-based intervention. Therefore, the aim of this study is to translate the paper-based intervention prototype into electronic format. The online prototype will be a) tested for acceptability and b) effect signal. The feasibility of the study design will be evaluated.

Methods
A sequential mixed methods approach, based on the UK Medical Research Council (MRC) Evaluation Framework. The intervention feasibility study will test the acceptability of content and delivery of the intervention and ascertain active feedback. The feasibility of the study design will be evaluated the recruitment, data collection, retention, and analysis strategies. A two-arm feasibility RCT with nested qualitative evaluation will be used to evaluate the newly developed intervention among 60 FMs. Participants will be recruited via Crohn’s & Colitis UK and Bowel Research UK charities. The 60 participants will be randomly allocated into intervention and control groups using 2:1 randomisation. The qualitative component will use purposive sampling from the intervention arm to elicit feedback on the content and format with up to 20 participants.

Anticipated Impact
Results from this intervention development and feasibility study will help revise the intervention, incorporate changes to the study protocol (if necessary), and develop a large-scale RCT for efficacy trailing of a complex intervention to benefit service users.
Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study
Authors: Chua Winnie , Khashaba Alya , Canagarajah Hansel , Nielsen Jens Cosedis , di Biase Luigi , Haeusler Karl Georg , Hindricks Gerhard , Mont Lluis , Piccini Jonathan , Schnabel Renate B , Schotten Ulrich , Wienhues-Thelen Ursula-Henrike , Zeller Tanja , Fabritz Larissa , Kirchhof Paulus 
Published: January 2024

Abstract

Aims
Different disease processes can combine to cause atrial fibrillation (AF). Their contribution to recurrent AF after ablation in patients is not known. Cardiovascular processes associated with recurrent AF after AF ablation were determined by quantifying biomolecules related to inflammation, metabolism, proliferation, fibrosis, shear stress, atrial pressure, and others in the AXAFA biomolecule study.

Methods and results
Twelve circulating cardiovascular biomolecules (ANGPT2, BMP10, CA125, hsCRP, ESM1, FABP3, FGF23, GDF15, IGFBP7, IL6, NT-proBNP, and hsTnT) were quantified in plasma samples obtained prior to a first AF ablation using high-throughput, high-precision assays. Cox regression was used to identify biomolecules associated with recurrent AF during the first 3 months after AF ablation. In 433 patients (64 years [58, 70]; 33% women), baseline concentrations of ANGPT2, BMP10, hsCRP, FGF23, FABP3, GDF15, and NT-proBNP were elevated in patients with recurrent AF (120/433; 28%). After adjustment for 11 clinical features and randomized treatment, elevated NT-proBNP [hazard ratio (HR) 1.58, 95% confidence interval (1.29, 1.94)], ANGPT2 [HR 1.37, (1.12, 1.67)], and BMP10 [HR 1.24 (1.02, 1.51)] remained associated with recurrent AF. Concentrations of ANGPT2, BMP10, and NT-proBNP decreased in patients who remained arrhythmia free, but not in patients with recurrent AF, highlighting their connection to AF. The other eight biomarkers showed unchanged concentrations.

Conclusion
Elevated concentrations of ANGPT2, BMP10, and NT-proBNP are associated with recurrent AF after a first AF ablation, suggesting that processes linked to disturbed cardiomyocyte metabolism, altered atrial shear stress, and increased load contribute to AF after AF ablation in patients.
Cost-Effectiveness of Community-Based Active Case Finding Strategy for Tuberculosis: Evidence From Shenzhen, China
Authors: Pei Xingtong , Zhong Tao , Yang Chongguang , Sun Li , Chen Meiru , Xu Mingming 
Published: January 2024

Abstract

Background
Active case finding (ACF) is a potentially promising approach for the early identification and treatment of tuberculosis patients. However, evidence on its cost-effectiveness, particularly in low- and middle-income countries, remains limited. This study evaluates the cost-effectiveness of a community-based ACF practice in Shenzhen, China.

Methods
We employed a Markov model-based decision analytic method to assess the costs and effectiveness of 3 tuberculosis detection strategies: passive case finding (PCF), basic ACF, and advanced ACF. The analysis was conducted from a societal perspective on a dynamic cohort over a 20-year horizon, focusing on active tuberculosis (ATB) prevalence and the incremental cost-effectiveness ratio (ICER).

Results
Compared to the PCF strategy, the basic and advanced ACF strategies effectively reduced ATB cases by 6.8 and 10.2 per 100 000 population, respectively, by the final year of this 20-year period. The ICER for the basic and advanced ACF strategies were ¥14 757 and ¥8217 per quality-adjusted life-year, respectively. Both values fell below the cost-effectiveness threshold.

Conclusions
Our findings indicate that the community-based ACF screening strategy, which targets individuals exhibiting tuberculosis symptoms, is cost-effective. This underscores the potential benefits of adopting similar community-based ACF strategies for symptomatic populations in tuberculosis-endemic areas.
Unearthing New ccr Genes and Staphylococcal Cassette Chromosome Elements in Staphylococci Through Genome Mining
Authors: Huang Jianguo , Xiao Jinhe , Wang Xiaokun , Xue Xuemei , Ma Yadong , Zhang Ziqian , Zheng Liangjun , Zafir Muhammad , Liu Pilong , Zhao Xin , Larsen Anders Rhod , Xue Huping 
Published: January 2024

Abstract
Staphylococcal cassette chromosome mec (SCCmec) typing is crucial for investigating methicillin-resistant Staphylococcus aureus (MRSA), relying primarily on the combination of ccr and mec gene complexes. To date, 19 ccr genes and 10 ccr gene complexes have been identified, forming 15 SCCmec types. With the vast release of bacterial genome sequences, mining the database for novel ccr gene complexes and SCC/SCCmec elements could enhance MRSA epidemiological studies. In this study, we identified 12 novel ccr genes (6 ccrA, 3 ccrB, and 3 ccrC) through mining of the National Center for Biotechnology Information (NCBI) database, forming 12 novel ccr gene complexes and 10 novel SCC elements. Overexpression of 5 groups of novel Ccr recombinases (CcrA9B3, CcrA10B1, CcrC3, CcrC4, and CcrC5) in a mutant MRSA strain lacking the ccr gene and extrachromosomal circular intermediate (ciSCC) production significantly promoted ciSCC production, demonstrating their biological activity. This discovery provides an opportunity to advance MRSA epidemiological research and develop database-based bacterial typing methods.
Biotic interactions outweigh abiotic factors as drivers of bark microbial communities in Central European forests
Authors: Dreyling Lukas , Penone Caterina , Schenk Noëlle Valérie , Schmitt Imke , Dal Grande Francesco 
Published: January 2024

Abstract
Bark surfaces are extensive areas within forest ecosystems, which provide an ideal habitat for microbial communities, through their longevity and seasonal stability. Here we provide a comprehensive account of the bark surface microbiome of living trees in Central European forests, and identify drivers of diversity and community composition. We examine algal, fungal, and bacterial communities and their interactions using metabarcoding on samples from over 750 trees collected in the Biodiversity Exploratories in northern, central, and southern Germany. We show that mutual biotic influence is more important than the abiotic environment with regard to community composition, whereas abiotic conditions and geography are more important for alpha diversity. Important abiotic factors are the relative humidity and light availability, which decrease the algal and bacterial alpha diversity but strongly increase fungal alpha diversity. In addition, temperature is important in shaping the microbial community, with higher temperature leading to homogeneous communities of dominant fungi, but high turnover in bacterial communities. Changes in the community dissimilarity of one organismal group occur in close relation to changes in the other two, suggesting that there are close interactions between the three major groups of the bark surface microbial communities, which may be linked to beneficial exchange. To understand the functioning of the forest microbiome as a whole, we need to further investigate the functionality of interactions within the bark surface microbiome and combine these results with findings from other forest habitats such as soil or canopy.
An analysis of muscle growth after proton beam therapy for pediatric cancer
Authors: Nitta Hazuki , Mizumoto Masashi , Li Yinuo , Oshiro Yoshiko , Fukushima Hiroko , Suzuki Ryoko , Hosaka Sho , Saito Takashi , Numajiri Haruko , Kawano Chie , Kamizawa Satoshi , Maruo Kazushi , Sakurai Hideyuki 
Published: January 2024

Abstract
Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal of the study was to examine the effect of proton beam therapy (PBT) on the growth of muscles included in the irradiated area. The subjects were 17 pediatric patients (age ≤ 5 years) who received PBT with a treatment field including a muscle on only one side out of a pair of symmetrical bilateral muscles and had imaging evaluations for at least 1 year after PBT. The thicknesses of the irradiated and non-irradiated (contralateral) muscles were measured retrospectively on CT or MRI axial images collected before and after PBT. The change of thickness divided by the period (years) for each muscle was compared between the irradiated and contralateral sides. Correlations of muscle growth with irradiation dose and age at the start of treatment were also evaluated. The median observation period was 39.2 months. The measurement sites included the erector spinae (n = 9), gluteus maximus (n = 5) and rhomboids + trapezius (n = 3) muscles. The average changes in muscle thickness were 0.24 mm/year on the irradiated side and 1.19 mm/year on the contralateral side, showing significantly reduced growth on the irradiated side (P = 0.001). Younger patients had greater muscle growth. Irradiation dose was not significant, but muscle growth tended to decrease as the dose increased, and muscles irradiated at &gt;50 Gy (RBE) showed little growth. These results show that muscle growth is affected by PBT and that long-term follow-up is needed to evaluate muscle growth retardation.
Variants in the SARS2 gene cause HUPRA syndrome with atypical features: two case reports and review of the literature
Authors: Lahham Elias Edward , Hasassneh Juhina Jamal , Adawi Dua Osamah , Ismail Mohamad Khaled 
Published: January 2024

Abstract
Hyperuricemia, pulmonary hypertension, renal failure in infancy, and alkalosis (HUPRA syndrome) is a rare autosomal recessive mitochondrial disease with a prevalence of &lt;1:1 000 000, due to variations in the seryl-tRNA synthetase (SARS2) gene encoding SARS on chromosome 19 (19q13.2). This study investigated two Palestinian girls from the same village who presented with progressive renal failure during infancy, with atypical clinical manifestations of HUPRA syndrome including leukopenia, anemia, salt wasting, renal failure, marked hyperuricemia, hypercholesterolemia, hyperlactatemia, and hypertriglyceridemia but without pulmonary hypertension or alkalosis. Instead, they showed acidosis on routine follow-up, distinguishing them from previous cases. Using single whole exome sequencing, we identified two homozygous pathogenic variants in the SARS2 gene (c.1175A&gt;G (p.D392G)) and (c.1169A&gt;G (p.D390G)). These cases with their unique phenotypes, expand the SARS2 pathogenic variant spectrum and describe clinical differences between homozygous and compound heterozygous variants.
Path Analysis of Factors Related to Burnout for Campus-Based Victim Advocates
Authors: Nightingale Sarah 
Published: January 2024

Abstract
Campus-based victim advocates provide support and assistance to victims of interpersonal violence in the college context. In this study of professional campus-based victim advocates, structural equation modeling (SEM) was used to assess the direct and indirect effects of factors related to burnout. A total of 208 full-time victim advocates employed at four-year college campuses across the United States participated in an online survey in the summer of 2021. SEM analysis found that secondary traumatic stress and organizational support had significant direct effects on the level of burnout in this population. Also, organizational support served as a mediating factor between perceptions of leadership and burnout, and secondary traumatic stress served as a mediating factor between organizational support and burnout. Higher education institutions can make changes at the organizational level to address burnout of victim advocates through manageable work hours, control over workload, fair compensation, and increased sense of community investment in interpersonal violence response.
The association between regional guidelines compliance and mortality in severe trauma patients: an observational, retrospective study
Authors: Duclos Gary , Heireche Fouzia , Siroutot Manon , Delamarre Louis , Sartorius Max-Antoine , Mergueditchian Celine , Velly Lionel , Carvelli Julien , Bordais Aurelia , Pilarczyk Estelle , Leone Marc 
Published: January 2024

Background and importance
Trauma is a major cause of mortality and morbidity. Regional trauma systems are the cornerstones of healthcare systems, helping to improve outcomes and avoid preventable deaths in severe trauma patients.

Objectives
The goal of this study was to evaluate the association between compliance with the guidelines of a regional trauma management system and survival at 28 days of severe trauma patients.

Design, settings and participants
We conducted a retrospective observational study from 1 January 2019 to 31 December 2019. All adult patients admitted for trauma at the University Hospital of Marseille (France) and requiring a pre-hospital medical team were analysed. Compliance with a list of 30 items based on the regional guidelines for the trauma management was evaluated. Each item was classified as compliant, not compliant or not applicable. The global compliance was calculated for each patient as the ratio between the number of compliant items over the number of applicable items.

Outcome measures and analysis
The primary aim was to measure the association between compliance with the guidelines and survival at 28 days using a logistic regression. Secondary objectives were to measure the association between compliance with the guidelines and survival at 28 days and 6 months according to the severity of the patients, using a cut-off of the injury severity score at 24.

Main results
A total of 494 patients with a median age of 35.0 (25.0–50.0) years were analysed. Global compliance with guidelines was 63%. Mortality at 28 days and 6 months was assessed at 33 (6.7%) and 37 (7.5%) patients, respectively. The level of compliance was associated with reduced mortality at 28 days [odds ratio (OR) at 0.94 and 95% confidence interval (CI) at 0.89–0.98]. In the subgroup of 122 patients with an injury severity score above 23, the level of compliance was associated with reduced mortality at 28 days [OR: 0.93 (95% CI: 0.88–0.99)] and 6 months [OR: 0.93 (95% CI: 0.87–0.99)].

Conclusion
Increased levels of compliance with the guidelines in severe trauma patients were associated with an increase in survival, notably in the most severe patients.
Can modulation of gut microbiota affect anthropometric indices in patients with non-alcoholic fatty liver disease? An umbrella meta-analysis of randomized controlled trials
Authors: Amini-Salehi Ehsan , Samethadka Nayak Sandeep , Maddineni Gautam , Mahapatro Abinash , Keivanlou Mohammad-Hossein , Soltani Moghadam Saman , Vakilpour Azin , Aleali Maryam Sadat , Joukar Farahnaz , Hashemi Mohammad , Norouzi Naeim , Bakhshi Arash , Bahrampourian Ali , Mansour-Ghanaei Fariborz , Hassanipour Soheil 
Published: January 2024

Background and aim:
Modulating the gut microbiota population by administration of probiotics, prebiotics, and synbiotics has shown to have a variety of health benefits in different populations, particularly those with metabolic disorders. Although the promising effects of these compounds have been observed in the management of patients with non-alcoholic fatty liver disease (NAFLD), the exact effects and the mechanisms of action are yet to be understood. In the present study, we aimed to evaluate how gut microbiota modulation affects anthropometric indices of NAFLD patients to achieve a comprehensive summary of current evidence-based knowledge.

Methods:
Two researchers independently searched international databases, including PubMed, Scopus, and Web of Science, from inception to June 2023. Meta-analysis studies that evaluated the effects of probiotics, prebiotics, and synbiotics on patients with NAFLD were entered into our umbrella review. The data regarding anthropometric indices, including body mass index, weight, waist circumference (WC), and waist-to-hip ratio (WHR), were extracted by the investigators. The authors used random effect model for conducting the meta-analysis. Subgroup analysis and sensitivity analysis were also performed.

Results:
A total number of 13 studies were finally included in our study. Based on the final results, BMI was significantly decreased in NAFLD patients by modulation of gut microbiota [effect size (ES): −0.18, 05% CI: −0.25, −0.11, P<0.001]; however, no significant alteration was observed in weight and WC (ES: −1.72, 05% CI: −3.48, 0.03, P=0.055, and ES: −0.24, 05% CI: −0.75, 0.26, P=0.353, respectively). The results of subgroup analysis showed probiotics had the most substantial effect on decreasing BMI (ES: −0.77, 95% CI: −1.16, −0.38, P<0.001) followed by prebiotics (ES: −0.51, 95% CI: −0.76, −0.27, P<0.001) and synbiotics (ES: -0.12, 95% CI: −0.20, −0.04, P=0.001).

Conclusion:
In conclusion, the present umbrella meta-analysis showed that although modulation of gut microbiota by administration of probiotics, prebiotics, and synbiotics had promising effects on BMI, no significant change was observed in the WC and weight of the patients. No sufficient data were available for other anthropometric indices including waist-to-hip ratio and waist-to-height ratio and future meta-analyses should be done in this regard.