bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to orchestrate participants of ecosystem to foster innovation: an exploratory analysis on the network level
Authors: Prabowo Gilang Mukti , Priyono Anjar , Suhartini  , Hidayat Anas 
Published: October 2023

PurposeSmall and medium-sized enterprises (SMEs), typically with limited resources, strive hard to obtain the trust of ecosystem participants as an orchestrator. Accordingly, the firms do not have sufficient legitimacy to persuade other parties to join their networks. This study aims to investigate how an SME operating in the publishing industry orchestrates ecosystem participants. In particular, the study analyzes how the orchestrating firm stimulates interactions among ecosystem participants.Design/methodology/approachCase study research with a qualitative approach has been documented as a well-accepted method for investigating complex phenomena and for theory building. Collected data from various informants and different collection techniques are triangulated to ensure validity. Cross-case analysis to identify common patterns is undertaken as the basis for developing a sound conclusion.FindingsThe study demonstrated what orchestrating firms should do to foster innovations and how they benefit from other participants in the ecosystem. The analysis identified the orchestrator's four roles: entrepreneurship networks, knowledge activation, innovation intermediary and network leadership. Among the four roles, there are interrelationships, and to some degree, these overlap. The orchestrating firm must emerge into the ecosystem and work together with all members of the ecosystem. Managers of the orchestrating firm and network members should collaborate to find the most beneficial configuration for all ecosystem participants.Research limitations/implicationsThis research is limited to the knowledge-intensive publishing industry. The use of specific industries closely related to innovation provides an advantage in the way that enables researchers to conduct depth analysis, but at the expense of generalizability, and therefore, future research can analyze different industries.Originality/valueThis study focuses on networks as the unit of analysis. Previous studies assumed individual firms as the unit of analysis and ignored the fact that companies interact with other companies when pursuing open innovation. The study focuses on the interactions between actors as the unit of analysis and on the role of orchestrators undertaken by an SME.
Till: using human rights education to examine citizenship and civil rights
Authors: Corrigan Sean 
Published: October 2023

PurposeThis practitioner article uses human rights education (HRE) to frame issues of social justice, particularly anti-Black racism, depicted in the film Till. Teachers cognizant of the need to address racism in American history often struggle to find resources that are accessible and meaningful for their students (Howard and Navarro, 2017; Vickery and Rodriguez, 2022). Furthermore, the use of film in social studies instruction can be an engaging way for students to develop conceptual knowledge and grapple with sensitive issues in history education (Stoddard, 2012).Design/methodology/approachTill (2022) is a powerful film that teachers can use to pursue anti-racist goals in their classrooms, and HRE provides an approach to analyze a horrible manifestation of racism in American history as well as frame larger systems of injustice. By using widely accepted standards of human dignity, such as the Universal Declaration of Human Rights, teachers can address dimensions of oppression and inequality with a more “neutral” or objective approach.FindingsGiven the current political climate that instills fear in educators who teach about racism, HRE can empower social studies teachers to engage students in analysis of a dominant force in American life.Originality/valueThe lesson plan offered in this article includes a film viewing guide, enrichment opportunities and an activity that connects themes in Till and the Civil Rights Movement to human rights concepts.
Functionality of pea protein isolate solutions is affected by reconstitution conditions
Authors: Chen Shiying , Hall Alexandra E. , Moraru Carmen I. 
Published: October 2023

AbstractPea protein isolate (PPI), a high‐concentration protein ingredient derived from peas, is increasingly utilized in food applications, including beverages, meat or dairy alternatives, and baked goods. The protein extraction process typically used to manufacture PPI renders the protein highly denatured, which can have a negative impact on its functionality. Therefore, it is critical to understand how to prepare and utilize PPI to maximize its functionality. The current study evaluates the effect of select reconstitution conditions on the structure and functionality of PPI, across a range of protein concentrations (4%–10%) relevant to a variety of food applications. Temperature during reconstitution with water and hydration time impacted both protein hydration and its functionality. Increasing reconstitution temperature from 20 to 60°C and increasing hydration time from 10 to 40 min decreased PPI particle size in solution and increased PPI solubility. Viscosity of PPI solutions also increased with mild heating and longer hydration time, whereas their flow behavior was highly dependent on protein concentration. Experimental data demonstrates that reconstitution conditions have a significant impact on PPI functionality. These findings can help food formulators develop high‐quality food products that utilize PPI as a functional ingredient.Practical ApplicationProtein in commercially available pea protein isolates (PPIs) is usually highly denatured, and thus, it is important to find ways to maximize its functionality in practical applications. The findings of this study inform food scientists how to leverage PPI at various protein concentrations with optimal reconstitution conditions to develop high‐quality products. Generally, mild heating and longer hydration times improve PPI functional performance.
To the future: An ecology of love, hope, and action
Authors: Woinarski John C. Z. 
Published: October 2023

AbstractThis is an edited version of a keynote address given at the 2023 Ecological Society of Australia conference (https://youtu.be/0JDJ9RdIkP4). I argue that the practice of ecology gifts us a unique capability to see and understand the beauty, intricacy and wonder of the natural world, but also powerful insight into biodiversity loss and its consequences. With such privilege we should take more responsibility for its protection. We should recognize that love drives our concern for nature and that emotion renders us more persuasive advocates. Despair at environmental loss is understandable but unhelpful, and we must find hope and build from it. Such hope comes, for example, from a sense of community connection to and concern for nature; in increasingly bold commitments by governments and many organizations to protect biodiversity; in the increased recognition and respect shown in Australia for First Nations management and perspectives on responsibility for country; and in those (albeit still too few) success stories of recovery.
Evaluation of the effect of graphene oxide‐based nanocomposites on smear layer by a scanning electron microscope: Laboratory investigation
Authors: Sehitoglu Gulbin , Cakici Fatih , Soylemez Saniye , Dengiz Cagatay 
Published: October 2023

AbstractThis study is to examine the effect of graphene oxide (GO) and GO‐based nanocomposites (GO_EDTA, GO_CHIT) on the smear layer by scanning electron microscopy (SEM). Sixty human single‐rooted anterior teeth were used. Samples were randomly categorised into six groups. Distilled water in group 1, 17% EDTA in group 2, chitosan (CHIT) solution in group 3, GO solution in group 4, GO_EDTA solution in group 5 and GO_CHIT in group 6 were used as irrigation solutions. Photomicrographs were acquired from the coronal, middle and apical parts of the samples by SEM. Statistical analyses were performed using Kruskal‐Wallis, Mann–Whitney U and Wilcoxon tests. There was a statistically significant difference among the groups (p < 0.003). Adding GO to CHIT and EDTA did not affect removing the smear layer in all segments (p < 0.003). Incorporating GO into EDTA and CHIT solutions did not change their interaction with the smear layer.
Oral Histories and Futures: Researching crises across the life‐course and the life‐course of crises
Authors: Hall Sarah Marie 
Published: October 2023

AbstractThis paper showcases Oral Histories and Futures interviews as an approach and series of innovations for researching crises with qualitative methods. It presents new possibilities for methodological innovations to embrace the multi‐directional and longitudinal temporalities of crises across the life‐course and the life‐course of crises. As an exciting avenue for methodological enhancement, I build on and bring together techniques across Oral Histories and creative biographical interviewing. Developed as part of a recent study exploring reproduction, economic crisis and the life‐course, with this approach I aimed to elicit people's experiences and opinions about their pasts, present and futures by innovating with traditional qualitative methodologies. I outline five areas of innovation—and associated observations, opportunities and obstacles—including a focus on younger generations, on the future, the inclusion of reflexive activities, interviewing in the midst of crises, and remote interviewing. Conclusions highlight what can be learned from an Oral Histories and Futures approach for thinking about socio‐temporal horizons.
Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction
Authors: Tan Enxue , Gao Zhihong , Wang Qian , Han Baosheng , Shi Honghong , Wang Lihua , Zhu Guozhen , Hou Yanjuan 
Published: October 2023

AbstractBerberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects. However, its role and underlying mechanisms in renal fibrosis remain unclear. Herein, we aimed to investigate the protective effects and molecular mechanisms of berberine against unilateral ureteric obstruction‐induced renal fibrosis. The results indicated that berberine treatment (50 mg/kg/day) markedly alleviated histopathological alterations, collagen deposition and inflammatory cell infiltration in kidney tissue and restored mouse renal function. Mechanistically, berberine intervention inhibited NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome activation and the levels of the inflammatory cytokine IL‐1β in the kidneys of unilateral ureteric obstruction mice. In addition, berberine relieved unilateral ureteric obstruction‐induced renal injury by activating adenosine monophosphate‐activated protein kinase (AMPK) signalling and promoting fatty acid β‐oxidation. In vitro models showed that berberine treatment prevented the TGF‐β1‐induced profibrotic phenotype of hexokinase 2 (HK‐2) cells, characterized by loss of an epithelial phenotype (alpha smooth muscle actin [α‐SMA]) and acquisition of mesenchymal marker expression (E‐cadherin), by restoring abnormal fatty acid β‐oxidation and upregulating the expression of the fatty acid β‐oxidation related‐key enzymes or regulators (phosphorylated‐AMPK, peroxisome proliferator activated receptor alpha [PPARα] and carnitine palmitoyltransferase 1A [CPT1A]). Collectively, berberine alleviated renal fibrosis by inhibiting NLRP3 inflammasome activation and protected tubular epithelial cells by reversing defective fatty acid β‐oxidation. Our findings might be exploited clinically to provide a potential novel therapeutic strategy for renal fibrosis.
Engaging marginal stakeholders on social networking sites. A cross‐country exploratory analysis among Generation Z consumers
Authors: Rossi Marco Valerio , Sasso Pasquale , Perna Andrea , Solima Ludovico 
Published: October 2023

AbstractThis research explores the marginal stakeholder engagement and propensity to value cocreation in the fast‐fashion industry by taking Generation Z consumers (GZCs) as observation unit and social networking sites (SNSs) as context of investigation. By undertaking 24 in‐depth interviews with US and Italian GZCs, the study uncovers the main elements that influence their engagement generation on SNSs and highlights that at least four main paradoxes (PXs) exist in this scenario. Specifically, the interviewees reported that they do not trust those brands that make them feel as marginal consumers (PX1) and that they are likely to be extremely loyal to those brands that actively take them into consideration in their activities on SNSs (PX2). In addition, although GZCs concerned about the environment, in most cases, they will buy repeatedly from fast‐fashion brands for convenience reasons (PX3). Finally, social dimension of GZCs engagement appears to be influenced by their peers' preferences (PX4). This research is the first that explored GZCs by considering them under the lenses of stakeholder engagement and offering novel insights about common believes on this generation of consumers. Therefore, theoretical and managerial implications are discussed to advance current knowledge on GZCs and to help the development of new strategies to engage them on SNSs.
Antiviral opportunities of Mannich bases derived from triterpenic N‐propargylated indoles
Authors: Petrova Anastasiya , Tretyakova Elena , Khusnutdinova Elmira , Kazakova Oxana , Slita Alexander , Zarubaev Vladimir , Ma Xinyuan , Jin Hongwei , Xu Huan , Xiao Sulong 
Published: October 2023

AbstractOleanolic and glycyrrhetic acids alkyne derivatives were synthesized as a result of propargylation of the indole NH‐group condensed with the triterpene A‐ring, the following aminomethylation led to a series of Mannich bases. The synthesized compounds were tested for their potential inhibition of influenza A/PuertoRico/8/34 (H1N1) virus in Madin‐Darby canine kidney (MDCK) cell culture and SARS‐CoV‐2 pseudovirus in baby hamster kidney‐21‐human angiotensin‐converting enzyme 2 (BHK‐21‐hACE2) cells. Mannich bases of oleanolic and glycyrrhetic acids N‐propargylated indoles 7, 8, and 12 were the most efficacious against influenza virus A with IC50 7–10 μM together with a low toxicity (CC50 > 145 μM) and high selectivity index SI value 20. Indolo‐oleanolic acid morpholine amide Mannich base holding N‐methylpiperazine moiety 9 showed anti‐SARS‐CoV‐2 pseudovirus activity with EC50 value of 14.8 μM. Molecular docking and dynamics modeling investigated the binding mode of the compounds 7 and 12 into the binding pocket of influenza A virus M2 protein and compound 9 into the RBD domain of SARS‐CoV‐2 spike glycoprotein.
Physical activity intervention improves executive function and language development during early childhood: The active early learning cluster randomized controlled trial
Authors: Olive Lisa S. , Telford Rohan M. , Westrupp Elizabeth , Telford Richard D. 
Published: October 2023

AbstractThis study aimed to determine the effects of the Active Early Learning (AEL) childcare center‐based physical activity intervention on early childhood executive function and expressive vocabulary via a randomized controlled trial. Three‐hundred‐and‐fourteen preschool children (134 girls) aged 3–5 years from 15 childcare centers were randomly assigned to the intervention (8 centers; n = 170 children) or control group (7 centers, n = 144 children) in May 2019. Participants were mostly Australian (85%) and from slightly higher areas of socio‐economic status than the Australian average. There was an AEL intervention effect on inhibition (β = 0.5, p = .033, d = 0.29) and expressive vocabulary (β = 1.97, p = .001, d = 0.24). Integration of the AEL physical activity intervention into the daily childcare routine was effective in enhancing children's executive function and expressive language development.
Impact of selexipag use within 12 months of pulmonary arterial hypertension diagnosis on hospitalizations and medical costs: A retrospective cohort study
Authors: Tsang Yuen , Stokes Michael , Kim Yong‐Jin , Tilney Rong , Panjabi Sumeet 
Published: October 2023

AbstractBackgroundOral selexipag, a prostacyclin pathway agent (PPA), is effective in patients with pulmonary arterial hypertension (PAH). The objective of this study is to assess the impact of initiating oral selexipag within 12 months of diagnosis on health outcomes.MethodsThis retrospective cohort study used data from Optum's de‐identified Clinformatics® Data Mart Database. PAH patients between 1 October 2015 and 30 September 2019 were included. Patients were also required to have received PAH medication within 12 months of their initial diagnosis. Study groups included patients who initiated selexipag within 12 months of PAH diagnosis (SEL ≤ 12) and those who did not initiate any PPA within 12 months of PAH diagnosis (No PPA ≤ 12). Inverse probability of treatment weighting was used to remove potential confounding between groups. Cox and Poisson regression models were used to compare hospitalization and disease progression. Generalized linear model with gamma distribution and log link was used to compare costs.ResultsSEL ≤ 12 had lower rate of all‐cause hospitalizations (rate ratio: 0.76, 95% confidence interval [CI]: 0.60, 0.96) versus no PPA ≤ 12, but no differences in PAH‐related hospitalization rate (rate ratio: 1.03, 95% CI: 0.79, 1.33) or risk of disease progression (hazard ratio: 1.01, 95% CI: 0.71, 1.44). SEL ≤ 12 incurred lower all‐cause (mean difference: −$23 623; 95% CI: −35 537, −8512) and PAH‐related total medical costs (mean difference: −$12 927; 95% CI: −19 559, −5679) versus no PPA ≤ 12.ConclusionSelexipag initiation within 12 months of PAH diagnosis demonstrated reductions in all‐cause hospitalization rate and medical costs.
Examining the adequacy of preoperative informed consent in a developing country: Challenges in the era of surgical specialisation
Authors: Ede Osita , Obadaseraye Oke R. , Anichi Ifeanyi , Mbaeze Chisom , Udemezue Chukwuka O. , Basil‐Nwachuku Chinonso , Madu Kenechi A. , Iyidobi Emmanuel C. , Anyaehie Udo E. , Nwadinigwe Cajetan U. , Ngwangwa Chidinma , Adetula Uto Essien 
Published: October 2023

AbstractPreoperative informed consent is a legal and ethical requirement that ensures patients understand a procedure, its associated risks and benefits, alternative treatment options, and potential complications to make an informed decision about their care. This cross‐sectional study evaluated the informed consent process for major orthopaedic surgeries at a tertiary hospital in Nigeria. A self‐administered questionnaire was used to collect data from 120 adult participants. Results showed that many patients do not read the consent form before signing it, and surgeons do not adequately explain the alternatives to surgery, potential risks, and available anaesthetic options. Higher‐educated patients are more likely to read the consent form. Surgeons performed well in explaining the nature of the condition and prognosis, the procedure's potential benefits, and answering patients' questions. The study emphasises the need to improve the informed consent process to ensure patients understand and can make rational decisions about their healthcare.
Spatio‐temporal species aggregations do not rule out interspecific competition in tree hollow spider assemblages
Authors: Martínez‐Devesa Gerard , Hernández‐Corral Jesús , Micó Estefanía 
Published: October 2023

Abstract
A community's biological diversity reflects coexistence between species. This often depends, to some extent, on whether there is competition for resources and how it is dealt with.
The nature of old‐growth tree hollows is confined and relatively isolated, which makes them ideal for investigating the competition phenomena between their inhabitants, such as Araneae.
The existence of interspecific competition in the structuring of tree hollow spider assemblages in Mediterranean forests was inferred by spatial co‐occurrence pattern analyses with null models at both the community and pairwise levels. The analysis included 36 spider species collected monthly with emergence traps for 1 year. The distribution of four ecological traits, body size and phenology on the resulting pattern type was discussed.
The analyses showed spatial segregation at the community level and spatial aggregations between species with different traits predominated at the pairwise level. Hunting strategy and body size were the main differential traits to facilitate these aggregations. In addition, only the aggregations led by Amaurobius scopolii–Scotophaeus scutulatus and Eratigena atrica–Liocranum majus also showed an overlap during their main activity period.
Community segregation and spatio‐temporal aggregations of species with differential traits suggest that interspecific competition is a very likely structuring factor of tree hollow spider assemblages. Instead, segregations at the pairwise level seem to result from other factors, for example, habitat preferences.
Clinical and radiographic features of external cervical resorption – An observational study
Authors: Patel Shanon , Abella Francesc , Patel Kreena , Lambrechts Paul , Al‐Nuaimi Nassr 
Published: October 2023

AbstractAimTo determine the prevalence of symptoms, clinical signs and radiographic presentation of external cervical resorption (ECR).MethodologyThis study involved 215 ECR lesions in 194 patients referred to the Endodontic postgraduate Unit at King's College London or Specialist Endodontic practice (London, UK). The clinical and radiographic findings (periapical [PA] and cone beam computed tomography [CBCT]) were readily accessible for evaluation. A checklist was used for data collection. Inferential analysis was carried out to determine if there was any potential association between type and location of tooth in the jaw as well as sex, age of the patient and ECR presentation and radiographic feature.ResultsEighty‐eight patients (94 teeth) were female and 106 patients were male (121 teeth), the mean age (±SD) was 41.5 (±17.7) years. Fifteen patients (7.7%) had more than one ECR lesion. The most affected teeth were maxillary central incisors (21.4% [46 teeth]) and mandibular first molars (10.2% [22 teeth]). ECR was most commonly detected as an incidental radiographic finding in 58.1% [125 teeth] of the cases. ECR presented with symptoms of pulpal/periapical disease in 23.3% [n = 50] and clinical signs (e.g. pink spot, cavitation) in 16.7% [36 teeth] of the cases.Clinical signs such as cavitation (14%), pink spot (5.1%) and discolouration (2.8%) were uncommon, but their incidence increased up to 24.7% when combined with other clinical findings. ECR was detected in the resorptive and reparative phases in 70.2% and 29.8% of the cases respectively.ConclusionECR appears to be quiescent in nature, the majority being asymptomatic and diagnosed incidentally from PA or CBCT. When assessed with the Patel classification, most lesions were minimal to moderate in relation to their height (1 or 2) and circumferential spread (A or B). However, the majority of ECRs were in (close) proximity to the pulp. Symptoms and clinical signs were associated with (probable) pulp involvement rather than the height and circumferential spread of the lesion. Clinical signs were more frequently associated when ECR affected multiple surfaces.
Failure to launch? Or a 30‐year career detour? A users’ manual for supporting second‐career scientists in your immunology lab
Authors: Nazzaro M Nicole 
Published: October 2023

AbstractLaboratory science sometimes looks like it's built exclusively for young people, but if you look closely, you’ll find another group of scientists waiting to join your lab: those of us who didn’t quite launch our careers on a normal trajectory. Welcoming a second‐career scientist into your lab takes time and resources, but may just be well worth it. Here's what one second‐career scientist wants you to know about supporting second careers in immunology.