bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Possible Case of Hypertensive Crisis With Aortic Dissection After an Anti-COVID-19 Vaccine
Authors: Mohsenian Leila , Noroozi Zahra , Farahmand Faramarz 
Published: February 2024

Aortic dissection, a potentially fatal event, usually presents with acute intense chest or back pain. Painless aortic dissections constitute about 10% of all cases. High blood pressure is a common finding in both painless and painful aortic dissections. During the coronavirus disease (COVID-19) pandemic, various anti-COVID vaccines have been massively used. Although these vaccines are generally safe, there is a small risk of adverse effects which are mostly mild and transient, but sometimes they could be life-threatening. We report a case of painless aortic dissection that occurred within minutes of receiving the COVID-19 inactivated vaccine. A 65-year-old woman with chronic controlled systemic hypertension developed slurred speech, decreased level of consciousness, generalized weakness, and dyspnea without chest, back, or abdominal pain a few minutes after receiving the second dose of inactivated COVID-19 vaccine; she had a systolic blood pressure of 220 mmHg and left-sided pleural effusion. Drainage of the pleural effusion revealed gross blood and a spiral chest and mediastinum CT with intravenous contrast showed a penetrating atherosclerotic ulcer in the descending aorta. Therefore, thoracic endovascular aortic repair (TEVAR) was carried out, and the patient was discharged in satisfactory condition after 3 days.
Seeing Black Girls in Their Glory: Cultivating Spaces that Facilitate Black Girls’ Psychological Safety
Authors: Inniss-Thompson Misha N. , Leath Seanna , Harris Jamelia N. 
Published: February 2024

Black girls are regularly exposed to physical, emotional, and psychological violence in schools. Spaces intentionally created for and by Black girls can offer them psychological safety, where they can feel comfortable being their authentic selves. In the current qualitative study, we explored Black adolescent girls’ sense of psychological safety using individual, semi-structured interviews with 16 girls ( Mage = 17.36 years) who participated in Black Girl Magic Crew (BGM), an after-school program in the Southeastern United States. This program was created for and with Black girls and focused on their identity development, mental health, and academic preparation. Drawing on the psychological framework of radical healing and Black feminism in qualitative inquiry, we depicted the practices and curricular elements that enabled the girls to feel psychologically safe in BGM. Findings demonstrated that within BGM, participants (a) were validated, (b) seen in their glory, and (c) freely expressed themselves. The authors discussed the implications of study findings for Black girls’ psychological safety and co-creating Black girl spaces that prioritize liberation and healing.
Comparing Survival Extrapolation within All-Cause and Relative Survival Frameworks by Standard Parametric Models and Flexible Parametric Spline Models Using the Swedish Cancer Registry
Authors: Chen Enoch Yi-Tung , Leontyeva Yuliya , Lin Chia-Ni , Wang Jung-Der , Clements Mark S. , Dickman Paul W. 
Published: February 2024

Background In health technology assessment, restricted mean survival time and life expectancy are commonly evaluated. Parametric models are typically used for extrapolation. Spline models using a relative survival framework have been shown to estimate life expectancy of cancer patients more reliably; however, more research is needed to assess spline models using an all-cause survival framework and standard parametric models using a relative survival framework. Aim To assess survival extrapolation using standard parametric models and spline models within relative survival and all-cause survival frameworks. Methods From the Swedish Cancer Registry, we identified patients diagnosed with 5 types of cancer (colon, breast, melanoma, prostate, and chronic myeloid leukemia) between 1981 and 1990 with follow-up until 2020. Patients were categorized into 15 cancer cohorts by cancer and age group (18–59, 60–69, and 70–99 y). We right-censored the follow-up at 2, 3, 5, and 10 y and fitted the parametric models within an all-cause and a relative survival framework to extrapolate to 10 y and lifetime in comparison with the observed Kaplan-Meier survival estimates. All cohorts were modeled with 6 standard parametric models (exponential, Weibull, Gompertz, log-logistic, log-normal, and generalized gamma) and 3 spline models (on hazard, odds, and normal scales). Results For predicting 10-y survival, spline models generally performed better than standard parametric models. However, using an all-cause or a relative survival framework did not show any distinct difference. For lifetime survival, extrapolating from a relative survival framework agreed better with the observed survival, particularly using spline models. Conclusions For extrapolation to 10 y, we recommend spline models. For extrapolation to lifetime, we suggest extrapolating in a relative survival framework, especially using spline models. Highlights For survival extrapolation to 10 y, spline models generally performed better than standard parametric models did. However, using an all-cause or a relative survival framework showed no distinct difference under the same parametric model. Survival extrapolation to lifetime within a relative survival framework agreed well with the observed data, especially using spline models. Extrapolating parametric models within an all-cause survival framework may overestimate survival proportions at lifetime; models for the relative survival approach may underestimate instead.
Reducing the burden of travel and environmental impact through decentralization of cancer care
Authors: Fattore Giovanni , Bobini Michela , Meda Francesca , Pongiglione Benedetta , Baldino Luca , Gandolfi Stefano , Confalonieri Licia , Proietto Manuela , Vecchia Stefano , Cavanna Luigi 
Published: February 2024

Life expectancy, quality of life and satisfaction of oncologic patients highly depend on access to adequate specialized services, that consider their conditions in a holistic way. The present study aims to evaluate the introduction of oncology services in an outpatient setting in a mountain village in Northern Italy. The initiative is evaluated using the three pillars of sustainability (social, economic and environmental) as dimensions that are often overlooked by healthcare policy makers. Using micro data on 18,625 interventions, we estimate the number of kilometers saved by patients (reduction of “travel burden” as indicator of social sustainability), the additional travel costs for the NHS (indicator of economic sustainability) and the implied reduction of CO2 emissions (indicator of environmental sustainability). Over the period July 2016–2021, the decentralized health center delivered 2,292 interventions saving 218,566 km for a corresponding value of €131,140. The additional costs for the NHS was €26,152. The reduction of CO2 emissions was 32.37 Tons (€5,989). Overall, the socio-economic benefit of reducing travel of care for the patients residing in this remote valley was €110,976. This study adds original understanding of the benefits of decentralizing oncologic care and shows its operational feasibility conditions. Given the modest number of similar projects, it provides evidence to policy makers and, especially, managers who are faced with the challenge to implement the decentralization of specialized services.
Does language shape the way we think? A review of the foreign language effect across domains
Authors: Purpuri Silvia , Vasta Nicola , Filippi Roberto , Wei Li , Mulatti Claudio 
Published: February 2024

Purpose and research question: This review investigates the influence of the foreign language effect (FLE) on moral decision-making, risk aversion, and causality perception. Recent research indicates that bilinguals employ different decision-making strategies according to the language in use (first vs. second language). Methodology: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, we conducted a comprehensive literature review. Our analysis focused on empirical studies, yielding 28 articles that met our inclusion criteria. Findings and conclusions: Our findings reveal that participants, when operating in a foreign language context, are more inclined to accept harm for improved outcomes, exhibit reduced risk aversion, and display moderated causal perceptions, particularly in emotionally charged contexts. The variability in study conclusions can be attributed to factors such as age, personality, language proficiency, and linguistic characteristics. Significance: Our results support previous findings in the FLE, highlight limitations, and provide suggestions for future research.
Relationship between dust allergen sensitization and cardiac autonomic function in patients with chronic obstructive pulmonary disease
Authors: Zeng Meie , Ye Shuifen , Huang Wanling , Deng Weiwei , Zou Simin , Huang Chunmei , Qiu Hanzhong 
Published: February 2024

Objective Cardiac autonomic function predicts cardiovascular disease risk. The aim of this study was to investigate the relationship between sensitization to dust allergens and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD), and to provide new ideas for the prevention of cardiovascular complications in these patients. Methods Immunoassays for sensitization to cats/dogs, cockroaches and dust mites were performed in 840 patients with COPD. Indicators of heart rate variability in these patients were used to assess cardiac autonomic function, including standard deviation of normal-to-normal intervals (SDNN), root-mean square of successive differences between normal-to-normal intervals (RMSSD), low-frequency power (LF), high-frequency power (HF), and LF/HF ratios, which were obtained based on ambulatory electrocardiographic monitoring data. The relationship between sensitization to these dust allergens and heart rate variability was explored using multivariate logistic regression. Findings The multivariate analyses showed that sensitization to total allergens was associated with reduced levels of SDNN, RMSSD, LF and HF and with increased levels of the LF/HF ratio in the patients with COPD ( p < .05). Conclusion Dust allergen sensitization may be associated with cardiac autonomic dysfunction in patients with COPD. Whether desensitization can prevent cardiovascular complications in these patients should be further explored.
Readmission Rates Among Acute Reperfusion Treatment Modalities for Patients With Ischemic Stroke
Authors: Arevalo C Yurany A. , Nanavati Hely D. , Lin Chen 
Published: February 2024

Background and purpose Understanding various aspects associated with readmission after acute ischemic stroke (AIS) is an important priority. Our study aims to examine whether 60-day readmission rates differed among patients with AIS who were treated with different acute reperfusion treatment modalities along with associated clinical factors. Methods This is a retrospective analysis of a continuous cohort of patient with AIS, who received either intravenous recombinant tissue plasminogen activator (IV rtPA), endovascular treatment (EVT) or both, and were discharged alive. Patients readmitted within 60 days were identified as the readmission group. Multivariable logistic regression was used to identify all-cause readmission post-stroke between treatment groups. Results The final cohort comprised of 358 patients with AIS receiving IV rtPA only (N = 160), EVT only (N = 106), or both (N = 92). Fifty-six patients were readmitted to the hospital within 60-day follow-up period. The adjusted logistic regression model indicated that compared to patients who received IV tPA only, patients receiving both IV rtPA and EVT had significantly lower odds (OR = .27; 95% CI = .10, .75)) of getting readmitted within 60-day post-discharge from stroke admission. Conclusion In this sample of AIS hospitalizations, treatment-type was positively associated with 60-day readmission. Future studies are necessary to understand whether treatment-related adverse events, and readmission are avoidable.
Empowered and engaged: Group exercise for adolescent depression – perspectives from adolescents, parents and healthcare professionals
Authors: Mortazavi Rebecca , Andersson Rebecca , Jarbin Håkan , Larsson Ingrid 
Published: February 2024

Objectives: Depression is increasing and is a leading cause of disease burden among adolescents. Available evidence-based treatments with medication or psychotherapy have modest effects. Aerobic exercise is a hopeful alternative as an augmenter or a stand-alone treatment. Qualitative studies have shown that participants in group exercise for adolescent depression experienced improved mood and a sense of achievement, commitment and empowerment. This study aimed to explore not only adolescents’ but also parents’ and healthcare professionals’ experiences of a group exercise intervention for adolescents with depression. Methods: Nine adolescents who had participated in a group aerobic exercise intervention for 12 weeks, eight parents and two healthcare professionals were interviewed. We used a latent qualitative content analysis with an inductive approach that resulted in nine sub-categories, three categories and an overarching theme. Results: The experiences of a group exercise intervention for adolescents with depression were expressed in the overarching theme ‘Group exercise for adolescent depression promotes empowerment and engagement in everyday life’, based on three categories: exercise alleviates depressive symptoms, exercise contributes to balance in life and exercise promotes self-esteem. However, there was variation in our results, in that not all participants experienced improvements from exercising. Adolescents described more varied experiences, while parents and healthcare professionals mainly expressed positive views. Conclusions: Our findings suggest that group exercise for adolescent depression promotes empowerment and engagement in everyday life, according to adolescents, and more clearly so according to parents and healthcare professionals.
Impaired T cells and “memory-like” NK-cell reconstitution is linked to late-onset HCMV reactivation after letermovir cessation
Authors: Lauruschkat Chris David , Muchsin Ihsan , Rein Alice Felicitas , Erhard Florian , Grathwohl Denise , Dölken Lars , Köchel Carolin , Nehmer Anne , Falk Christine Susanne , Grigoleit Götz Ulrich , Einsele Hermann , Wurster Sebastian , Kraus Sabrina 
Published: February 2024

Abstract
Allogeneic hematopoietic stem cell transplantation (alloSCT) is the only cure for many hematologic malignancies. However, alloSCT recipients are susceptible to opportunistic pathogens, such as human cytomegalovirus (HCMV). Letermovir prophylaxis has revolutionized HCMV management, but the challenge of late HCMV reactivations has emerged. Immunological surrogates of clinically significant HCMV infection (csCMVi) after discontinuation of letermovir remain to be defined. Therefore, we studied natural killer (NK)-cell reconstitution along with the global and HCMV pp65-specific T-cell repertoire of 24 alloSCT recipients at 7 time points before (day +90) and after (days +120-270) cessation of letermovir prophylaxis. Patients who experienced csCMVi had lower counts of IFN-γ+ HCMV–specific CD4+ and CD8+ T cells than HCMV controllers. Furthermore, patients with csCMVi displayed late impairment of NK-cell reconstitution, especially suppression of “memory-like” CD159c+CD56dim NK-cell counts that preceded csCMVi events in most patients. Moreover, several surrogates of immune reconstitution were associated with the severity of HCMV manifestation, with patients suffering from HCMV end-organ disease and/or refractory HCMV infection harboring least HCMV–specific T cells and “memory-like” NK cells. Altogether, our findings establish an association of delayed or insufficient proliferation of both HCMV–specific T cells and “memory-like” NK cells with csCMVi and the severity of HCMV manifestations after discontinuation of letermovir prophylaxis.
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development
Authors: Wang Xiangyan , Zhang Yan , Yu Jianjie , Ma Yabo , Xu Yaxiu , Shi Jiaqi , Qi Zhipeng , Liu Xinfeng 
Published: February 2024

Abstract
Background
CircRNAs are a class of noncoding RNAs with tissue- and development-specific expression characteristics. In many mammals, primordial follicle development begins in the embryonic stage. However, the study of circRNAs in primordial follicle development in mice has not been reported.

Results
In this study, ovaries were collected from mouse foetuses at 15.5 days post coitus (dpc) and 17.5 dpc, which are two key stages of primordial follicle development. A total of 4785 circRNAs were obtained by using RNA-seq. Of these, 83 differentially expressed circRNAs were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that these differential circRNAs were mainly involved in the regulation of reproductive development. Through qRT-PCR, back-splice sequence detection and enzyme digestion protection experiments, we found that circ-009346, circ-014674, circ-017054 and circ-008296 were indeed circular. Furthermore, circ-009346, circ-014674 and circ-017054 were identified as three key circRNAs by analysing their expression in the ovaries of mice at different developmental stages. The circRNA-miRNA-mRNA interaction network was constructed and validated for target miRNA and mRNA using qRT-PCR. The interacting genes circ-009346, circ-014674, and circ-017054 were subjected to KEGG enrichment analysis. We found that circ-014674 may participate in the assembly and reserve of primordial follicles through oestrogen and the Janus kinase (JAK) signal transducer and activator of transcription (STAT) signalling pathway (JAK-SATA). Circ-009346 and circ-017054 may have similar functions and are involved in the activation and growth of primordial follicles through the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signalling pathways.

Conclusions
Based on our findings, three circRNAs associated with primordial follicle development were identified, and their potential mechanisms of regulating primordial follicle development were revealed. These findings will help us better understand the molecular mechanism of circRNAs in primordial follicles and provide important references and targets for the development of primordial follicles.
Genetic parameter changes and age−age correlations in Pinus koraiensis growth over 40-year progeny testing
Authors: Lee Kyungmi , Oh Changyoung , Kim In Sik 
Published: February 2024

Abstract
Background
Early selection in tree breeding could be achieved by addressing the longevity of tree improvement activities. Genetic parameter changes and age–age correlations are essential for determining the optimal timing of early selection. Practical tracking of genetic parameters of Pinus koraiensis, a major timber species with economic and ecological value, has become feasible as its progeny testing has entered the mid-term age in Korea. However, research on the age−age correlation of P. koraiensis as progeny trials approach rotation age is limited. This study aimed to investigate genetic parameter trends and age−age correlations in P. koraiensis progeny. P. koraiensis progeny were assessed at two sites using a linear mixed-effects model with two-dimensional spatial autoregressive structure. Height, diameter, and volume growth were measured in 11 assessments over 40 years.

Results
Genetic parameters, such as height and diameter, showed different patterns of change. The heritability ranged for the three growth traits in 0.083–0.710, 0.288–0.781, and 0.299–0.755 across the sites and age. Height heritability and its coefficient of variance decreased, whereas the diameter and volume estimates remained relatively constant. Correlations with Age 40 for phenotypic, genetic, and rank of breeding values ranged between 0.16 and 0.92, 0.594 and 0.988, and 0.412 and 0.965, respectively. These correlations generally increased as the age approached Age 40, with particularly high levels observed at Age 26 and Age 30.

Conclusion
The observed genetic trends in P. koraiensis progeny testing offer valuable insights for early and precise selection. Notably, selecting superior genotypes at Ages 26–30 is supported by discernible genetic gains and robust correlations. Future research should integrate unbalanced data for selecting mother trees or families and conduct a comprehensive economic analysis of early selection to validate its practical benefits.
Exploration of neuron heterogeneity in human heart failure with dilated cardiomyopathy through single-cell RNA sequencing analysis
Authors: Cui Yu-Hui , Wu Chun-Rong , Xu Dan , Tang Jian-Guo 
Published: February 2024

Abstract
Objective
We aimed to explore the heterogeneity of neurons in heart failure with dilated cardiomyopathy (DCM).

Methods
Single-cell RNA sequencing (scRNA-seq) data of patients with DCM and chronic heart failure and healthy samples from GSE183852 dataset were downloaded from NCBI Gene Expression Omnibus, in which neuron data were extracted for investigation. Cell clustering analysis, differential expression analysis, trajectory analysis, and cell communication analysis were performed, and highly expressed genes in neurons from patients were used to construct a protein-protein interaction (PPI) network and validated by GSE120895 dataset.

Results
Neurons were divided into six subclusters involved in various biological processes and each subcluster owned its specific cell communication pathways. Neurons were differentiated into two branches along the pseudotime, one of which was differentiated into mature neurons, whereas another tended to be involved in the immune and inflammation response. Genes exhibited branch-specific differential expression patterns. FLNA, ITGA6, ITGA1, and MDK interacted more with other gene-product proteins in the PPI network. The differential expression of FLNA between DCM and control was validated.

Conclusion
Neurons have significant heterogeneity in heart failure with DCM, and may be involved in the immune and inflammation response to heart failure.