bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence that highly canalized fetal traits are sensitive to intergenerational effects of maternal developmental nutrition
Authors: Ragsdale Haley B. , Lee Nanette R. , Kuzawa Christopher W. 
Published: November 2023

AbstractObjectivesMaternal experiences before pregnancy predict birth outcomes, a key indicator of health trajectories, but the timing and pathways for these effects are poorly understood. Here we test the hypothesis that maternal pre‐adult growth patterns predict pregnancy glucose and offspring fetal growth in Cebu, Philippines.MethodsUsing multiple regression and path analysis, gestational age‐adjusted birthweight and variables reflecting infancy, childhood, and post‐childhood/adolescent weight gain (conditional weights) were used to predict pregnancy HbA1c and offspring birth outcomes among participants in the Cebu Longitudinal Health and Nutrition Survey.ResultsMaternal early/mid‐childhood weight gain predicted birth weight, length, and head circumference in female offspring. Late‐childhood/adolescent weight gain predicted birth length, birth weight, skinfold thickness, and head circumference in female offspring, and head circumference in male offspring. Pregnancy HbA1c did not mediate relationships between maternal growth and birth size parameters.DiscussionIn Cebu, maternal growth patterns throughout infancy, childhood, and adolescence predict fetal growth via a pathway independent of circulating glucose, with stronger impacts on female than male offspring, consistent with a role of developmental nutrition on offspring fetal growth. Notably, the strength of relationships followed a pattern opposite to what occurs in response to acute pregnancy stress, with strongest effects on head circumference and birth length and weakest on skinfolds. We speculate that developmental sensitivities are reversed for stable, long‐term nutritional cues that reflect average local environments. These findings are relevant to public health and life‐history theory as further evidence of developmental influences on health and resource allocation across the life course.
Click‐Chemistry‐Mediated Cell Membrane Glycopolymer Engineering to Potentiate Dendritic Cell Vaccines
Authors: Yang He , Xiong Zijian , Heng Xingyu , Niu Xiaomeng , Wang Yichen , Yao Lihua , Sun Lele , Liu Zhuang , Chen Hong 
Published: November 2023

AbstractDendritic cell vaccine (DCV) holds great potential in tumor immunotherapy owing to its potent ability in eliciting tumor‐specific immune responses. Aiming at engineering enhanced DCV, we report the first effort to construct a glycopolymer‐engineered DC vaccine (G‐DCV) via metabolicglycoengineering and copper‐free click‐chemistry. Model G‐DCV was prepared by firstly delivering tumor antigens, ovalbumin (OVA) into dendritic cells (DC) with fluoroalkane‐grafted polyethyleneimines, followed by conjugating glycopolymers with a terminal group of dibenzocyclooctyne (DBCO) onto dendritic cells. Compared to unmodified DCV, our G‐DCV could induce stronger T cell activation due to the enhanced adhesion between DCs and T cells. Notably, such G‐DCV could more effectively inhibit the growth of the mouse B16‐OVA (expressing OVA antigen) tumor model after adoptive transfer. Moreover, by combination with an immune checkpoint inhibitor, G‐DCV showed further increased anti‐tumor effects in treating different tumor models. Thus, our work provides a novel strategy to enhance the therapeutic effectiveness of DC vaccines.
Subnanometric Bismuth Clusters Confined in Pyrochlore‐Bi2Sn2O7 Enable Remarkable CO2 Photoreduction
Authors: Yan Wenkai , Zhang Yajun , Bi Yingpu 
Published: November 2023

AbstractThe development of highly efficient photocatalysts for conversion of carbon dioxide (CO2) with water (H2O) into chemical fuels is of great importance for energy sustainability and carbon resource utilization. Herein, we demonstrated a facile hydrothermal method for in situ construction of subnanometric Bi metallic clusters in pyrochlore‐Bi2Sn2O7 frameworks, leading to the remarkable improvements of photocatalytic performances for CO2 reduction into CO in the absence of sacrificial reagent. More specifically, an outstanding CO evolution activity of 114.1 μmol g−1 h−1 has been achieved, more than 20‐fold improvement compared with the pristine Bi2Sn2O7 (5.7 μmol g−1 h−1). Detailed experiments together with in situ characterizations reveal that the spatially confined Bi clusters could significantly promote charge‐separation/electron‐enrichment and adsorption/activation of CO2 molecules, which provides highly efficient reaction channels to facilitate the generation of *COOH intermediate as well as the subsequent desorption of *CO towards CO formation. These demonstrations provide an important knowledge for precise design and fabrication of highly efficient photocatalysts for CO2 conversion into solar fuels.
Energy efficiency enhancement of a thermal power plant by novel heat integration of Internal Combustion Engine, Boiler, and Organic Rankine Cycle
Authors: Talib Razia , Khan Zakir , Khurram Shahzad , Inayat Abrar , Ghauri Moinuddin , Abbas Mohsin , Watson Ian 
Published: November 2023

AbstractThe utilization of waste energy contributes to reducing carbon emissions and mitigating global warming. A novel heat integration system comprising an Internal Combustion Engine (ICE), Boiler, and Organic Rankine Cycle (ORC) coupling is techno‐economically examined in this study. The feasibility of waste heat recovery from industrial boilers of a thermal power plant (Gadoon Textile Mills Limited, Pakistan) having 2.66‐MW capacity was assessed. This was done by efficiently harnessing the waste heat from boiler exhaust gas by coupling an existing system with an ORC. A steady‐state simulation model of the ICE‐Boiler‐ORC system was developed through Power Plant Simulator and Designer (PPSD) software to perform a multiparametric study. Additional heat power (3710 kW) was extracted from the boilers' waste gases through ORC. Consequently, the overall plant thermal efficiency was enhanced from 61.84% to 82.68% and the overall net electric efficiency of the existing system was increased by 0.9%. The average payback period was found 4.2 years based on different plant operation scenarios and equipment prices (Chinese or European origin). Therefore, the proposed system holds significant technical and economic potential for enhancing energy efficiency through low‐grade waste heat and proves to be economically viable with a short payback period.
Eco‐friendly liquid chromatography method for the quantification of ibrutinib in a pharmaceutical dosage form
Authors: Chatki Pankaj Kisan , Mahajan Ujwala N. 
Published: November 2023

AbstractThe objective of this study was to quantitatively determine Bruton's tyrosine kinase inhibitor ibrutinib in its capsule dosage form and assess the homogeneity of the dosage form using green chromatography. The chromatographic method using gradient elution mode was optimized and validated in accordance with the International Council for Harmonization guidelines. The analysis was conducted on a Zodiac C18 column (75 × 4.6 mm and 3.5 μm) using a mobile phase consisting of pH 5.5 potassium phosphate buffer (mobile phase A) and 90% ethanol in milli‐Q water (mobile phase B), with a flow rate set at 0.6 mL/min. Based on the validation data, the accuracy results fell within the range of 99.1%–100.6%. The relative standard deviation (% RSD) from precision for both the assays and the uniformity of dosage by content uniformity were determined to be 0.82 and 1.16, respectively. The correlation coefficient obtained from the linearity experiment was 0.999, indicating a strong linear relationship. The greenness of the developed method was assessed using various tools, including the National Environmental Methods Index (NEMI) pictogram, Modified NEMI, Analytical Eco‐score calculation, Green Analytical Procedure Index (GAPI) pictogram, Analytical GREEnness (AGREE), and AGREE preparation (AGREEprep). The obtained greenness profile suggests that the optimized LC method is an excellent greener method, supported by the analytical eco‐score of 86.
Food overconsumption: Concept and its measurement
Authors: Mathur Anil 
Published: November 2023

AbstractFood overconsumption has serious and far‐reaching effects on people, including obesity, negative health outcomes, reduced life expectancy, and financial hardship. Attempts to understand the underlying factors that contribute to food overconsumption are undermined by a lack of clarity about the concept of food overconsumption. This study reports the development of a scale to measure the extent to which individuals engage in food overconsumption (FOC). The FOC scale predicts many outcomes associated with excessive eating. The development of the scale, including item generation, scale refinement, and establishment of its reliability are first reported. This is followed by analyses showing that the FOC is distinct from clinical conditions associated with various eating disorders and measured using well‐established scales (e.g., power‐of‐food scale, three‐factor eating questionnaire, and Dutch eating behavior questionnaire). Based on multiple studies, additional analysis is reported showing that the FOC scale is a reliable and valid measure that can be used to measure food overconsumption. Implications of these findings are also discussed.
Immersive technology and cause‐related marketing: The role of personalization and value co‐creation
Authors: Luan Chi‐Cheng , Phan The Anh 
Published: November 2023

AbstractThis research conducted two studies to investigate the impact of immersive technology adoption on facilitating sustainable consumption behavior according to the perceived value co‐creation model. The first study used an online survey to examine the mediating effect of value co‐creation on the relationship between personalized values and sustainable behavioral intentions in adopting the 360‐degree video. In contrast, the second experimented to investigate the perceived value co‐creation model in adopting the virtual reality game. We collected 501 U.S. participants for watching the video about the presentation of a marine environment in Study 1, while recruited 92 college students in Taiwan to play the game regarding beach cleaning in Study 2. We found that immersive technologies can facilitate personalized values for value co‐creation, leading to increased intention to support, in this case, beach cleaning. The study provides theoretical contributions and managerial implications, providing evidence to show the potential of immersive technologies used in cause‐related marketing associated with sustainable consumption. Prior studies have shown that consumers perceive uncertain toward ethical attributes in sustainable consumption, leading to their low engagement. This research contributes to a solution of the problem by adopting immersive technologies to increase value co‐creation for purchasing cause‐related products.
Dehydrogenative Electrochemical Synthesis of N‐Aryl‐3,4‐Dihydroquinolin‐2‐ones by Iodine(III)‐Mediated Coupling Reaction
Authors: Bieniek Jessica C. , Mashtakov Boris , Schollmeyer Dieter , Waldvogel Siegfried R. 
Published: November 2023

AbstractElectrochemically generated hypervalent iodine(III) species are powerful reagents for oxidative C−N coupling reactions, providing access to valuable N‐heterocycles. A new electrocatalytic hypervalent iodine(III)‐mediated in‐cell synthesis of 1H‐N‐aryl‐3,4‐dihydroquinolin‐2‐ones by dehydrogenative C−N bond formation is presented. Catalytic amounts of the redox mediator, a low supporting electrolyte concentration and recycling of the solvent used make this method a sustainable alternative to electrochemical ex‐cell or conventional approaches. Furthermore, inexpensive, readily available electrode materials and a simple galvanostatic set‐up are applied. The broad functional group tolerance could be demonstrated by synthesizing 23 examples in yields up to 96 %, with one reaction being performed on a 10‐fold higher scale. Based on the obtained results a sound reaction mechanism could be proposed.
Phenomenological‐based model of direct blue 2 adsorption on corncob in a fixed‐bed
Authors: Presiga‐Posada Nathaly , Alvarez Hernan , Hormaza Angelina 
Published: November 2023

AbstractThis work presents a phenomenologically based semi‐physical model (PBSM) for the liquid–solid adsorption process, which has been experimentally validated. Two modes of operation of adsorption of direct blue 2 dye (DB2) on corn cobs in a fixed bed are discussed by applying the PBSM. The first mode of operation is the typical continuous liquid flow, whereas the second is a semicontinuous mode with the recirculation of liquid leaving the column. These modes of operation were used to illustrate different ways in which the system reaches equilibrium conditions. The equilibrium distribution curve (EDC) for low DB2 concentration was reached with the best fit using the Langmuir–Freundlich model (). The local mass transfer coefficient for the solid phase was evaluated by the PBSM deduction, and subsequently, the diffusivity of the surface solid was experimentally evaluated through comparison in terms of the PBSM. Regardless of the mode of operation, surface diffusion is associated with only the nature of the adsorbent material rather than the concentration of the liquid phase. In addition, the PBSM exhibited liquid and solid concentration changes at different points in the column. Moreover, different operating curves of the process were constructed and validated, exhibiting similar results when comparing the predictions of the model and the experimental data. These findings support the strength of the constructed model, enabling its extension to other adsorbent–dye systems.
Green synthesis of copper oxide nanoparticles: Characterization and applications for environmental and biomedical fields
Authors: Naaz Shazia , Shet Vinayaka Babu , Mubarak Nabisab Mujawar 
Published: November 2023

AbstractIn recent years, there has been an increasing interest in the development of plant‐based nanoparticles due to their numerous benefits over conventional physio‐chemical methods, including sustainability and environmental safety. Green synthesis, a process that produces safe and sustainable goods without the use of harsh chemicals or other harmful processes, is gaining popularity. The current study focuses on the green synthesis of copper oxide nanoparticles using Piper nigrum leaf extracts, their characterization, and applications. The synthesis of nanoparticles was confirmed by changes in colour, further endorsed by UV–visible spectroscopy. Copper oxide (CuO) nanoparticles were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). CuO nanoparticle sizes ranged between 58.23 and 69.89 nm and were spherical in shape. FTIR results indicated a functional group capped on the nanoparticle surface. The antibacterial activity of the copper oxide nanoparticles was tested, and they exhibited the significant decrease in bacterial concentration and the largest zone of inhibition, making them an efficient disinfectant. Antimicrobial activity against Bacillus subtilis and Escherichia coli was observed. Furthermore, the synthesized CuO nanoparticles exhibited a high affinity for safranin dyes and demonstrated maximum removal efficiency. This makes them an effective agent for removing dyes in wastewater from industries such as clothing manufacturing. Safranin dye was successfully removed with an efficiency of 78% using nanoparticles. In conclusion, the green synthesis of copper oxide nanoparticles using plant extracts presents an eco‐friendly and sustainable approach for producing nanoparticles with a wide range of potential applications.
Colourless distributed combustion effects on a pre‐mixed coke oven gas flame
Authors: Tasdemir Sezgin , Karyeyen Serhat 
Published: November 2023

AbstractFuels consisting of high hydrogen concentration can be consumed under colourless distributed combustion (CDC) to suppress flashback tendency in premixed conditions. Higher NOX challenges can also be overcome through CDC. For those purposes, coke oven gas was consumed under CDC within the scope of this study. To achieve CDC, or diluents were introduced into the oxidizer so that oxygen concentration in the oxidizer would be decreased from 21% O2 to its lean blow‐off limits. Excess air ratios were determined as λ = 1.2 and λ = 1.5 along with a thermal power of 10 kW under premixed conditions. A commercial computational fluid dynamics code was used to predict temperature distribution and , CO, and emissions. 162‐step reactions created with GRI‐Mech 3.0 chemical kinetics was integrated to the eddy dissipation concept combustion model. The temperature and profiles predicted were compared with the experimental results. Consistency was achieved at ~95% for temperature profiles, and almost 100% for profiles between the measured and the predicted ones. According to the results, it is concluded that a more homogeneous temperature distribution with the ~21% decrease in the maximum temperature was observed, and there was about 96% decrease in level. It was also demonstrated that using as a diluent is more effective in terms of temperature distribution over the combustor and reduction, while dilution with is more effective in terms about 70% in decrease on CO.
Asymmetric Two‐Component Alkenyl Catellani Reaction for the Construction of C—N Axial Chirality†
Authors: Wu Chenggui , Liu Ze‐Shui , Shang Yong , Liu Chang , Deng Shuang , Cheng Hong‐Gang , Cong Hengjiang , Jiao Yinchun , Zhou Qianghui 
Published: November 2023

Comprehensive SummaryHerein, we report an asymmetric two‐component alkenyl Catellani reaction for the construction of C—N axial chirality through a palladium/chiral norbornene cooperative catalysis and an axial‐to‐axial chirality transfer process. Various partially aromatic iodinated 2‐pyridones, quinolones, coumarin and uracil substrates react with 2,6‐disubstituted aryl bromides with a tethered amide group, to afford a wide variety of polycyclic C—N atropisomers (38 examples, up to 97% e.e.). The obtained C—N axial chirality originates from the preformed transient C—C axial chirality with high fidelity. The synthetic utility of this chemistry is demonstrated by facile preparation of complex quinoline and pyridine based C—N atropisomers through a N‐deprotection and aromatization sequence. In addition, a remote axial‐to‐central diastereoinduction process dictated by C—N axial chirality is observed with excellent diastereocontrol.
Tumor‐infiltrating immune cell score as an independent prognostic predictor for endometrial carcinoma: Insights from a comprehensive analysis of the immune landscape
Authors: Zhang Liping , Zhu Qiaoying , Zhao Qi , Lin Xueping , Song Hui , Liu Hong , Zhu Guiquan , Lu Shun , Cao Bangrong 
Published: November 2023

AbstractBackgroundImmune cells are crucial components in the tumor microenvironment and have a significant impact on the outcomes of patients.AimsHere, we aimed to establish a prognostic score based on different types of tumor‐infiltrating immune cells for Endometrial Carcinoma (EC).Methods and ResultsWe enrolled and analyzed 516 EC patients from The Cancer Genome Atlas. The relative abundance of 22 immune cells were estimated by using the CIBERSORTx algorithm. Cox regression was performed to identify potential prognostic immune cells, which were used to develop a Tumor‐infiltrating Immune Cell Score (TICS). The prognostic and incremental value of TICS for overall survival were compared with traditional prognostic factors using the C‐index and decision curves. Clustering analysis using all immune cells identified three immune landscape subtypes, which had weak correlation with survival. A TICS was constructed using CD8T cells, resting memory CD4 T cells, activated NK and activated DCs, and classified patients as low‐, moderate‐ and high‐risk subgroups. The low‐risk subgroup had higher tumor mutation burden and activation of IL2/STAT5, IL2/STAT3 and IFN‐gamma response pathways. Conversely, the high‐risk subgroup was associated with DNA copy number variation, hypoxia and EMT process. The TICS subgroups significantly predicted overall survival, which was independent of patient age, tumor stage, grade and molecular classification. Moreover, we developed a nomogram incorporating TICS and clinicopathologic factors, which significantly improved the predictive accuracy compared to the clinicopathologic model alone.ConclusionThe TICS is an effective and independent prognostic predictor for EC patients and may serve as a useful supplement to clinicopathological factors and molecular subtyping.
Genetic diversity of a short‐ranged endemic terrestrial snail
Authors: Gretgrix Lachlan J. , Decker Orsi , Green Peter T. , Köhler Frank , Moussalli Adnan , Murphy Nicholas P. 
Published: November 2023

AbstractThe factors that influence population structure and connectivity are unknown for most terrestrial invertebrates but are of particular interest both for understanding the impacts of disturbance and for determining accurate levels of biodiversity and local endemism. The main objective of this study was to determine the historical patterns of genetic differentiation and contemporary gene flow in the terrestrial snail, Austrochloritis kosciuszkoensis (Shea & O. L. Griffiths, 2010). Snails were collected in the Mt Buffalo and Alpine National Parks in Victoria, in a bid to understand how populations of this species are connected both within continuous habitat and between adjacent, yet separate environments. Utilising both mitochondrial DNA (mtDNA) and single nucleotide polymorphism (SNP) data, the degree of population structure was determined within and between sites. Very high levels of genetic divergence were found between the Mt Buffalo and Alpine snails, with no evidence for genetic exchange detected between the two regions, indicating speciation has possibly occurred between the two regions. Our analyses of the combined mtDNA and nDNA (generated from SNPs) data have revealed patterns of genetic diversity that are consistent with a history of long‐term isolation and limited connectivity. This history may be related to past cycles of changes to the climate over hundreds of thousands of years, which have, in part, caused the fragmentation of Australian forests. Within both regions, extremely limited gene flow between separate populations suggests that these land snails have very limited dispersal capabilities across existing landscape barriers, especially at Mt Buffalo: here, populations only 5 km apart from each other are genetically differentiated. The distinct genetic divergences and clearly reduced dispersal ability detected in this data explain the likely existence of at least two previously unnamed cryptic Austrochloritis species within a 30–50 km radius, and highlight the need for more concentrated efforts to understand population structure and gene flow in terrestrial invertebrates.