bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and validation of prognostic features of amino acid metabolism-related lncRNAs in hepatocellular carcinoma
Authors: CHENG LVE , Niu Junwei , Li Shengwei 
Published: November 2023

Abstract
Background

As an important part of cellular energy metabolism, amino acid metabolism provides energy support for tumor progression. In recent years, it has been found that in addition to traditional proteins, long-stranded non-coding RNAs (lncRNAs) are also involved in amino acid metabolism in tumors. However, potential lncRNA biomarkers that potentially regulate amino acid metabolism and affect the prognosis of HCC patients remain to be further explored.

Materials and Methods

Genomic and clinical data were obtained from The Cancer Genome Atlas (TCGA) database, and amino acid metabolism-related genes were obtained from the Molecular Signature Database v5.1 (MSigDB). Prognostic features were constructed by co-expression analysis and Cox regression analysis. Patients were divided into high-risk and low-risk groups, and then independent prognostic analysis and ROC curve plotting were performed to assess the prognostic value of the features. Subsequently, immune-related functions of lncRNA and tumor mutational burden (TMB) were analyzed. Finally, we analyzed amino acid metabolism-related lncRNAs using the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm to determine their sensitivity to potential drugs for hepatocellular carcinoma.

Results

A total of 6 lncRNAs related to amino acid metabolism were obtained as LINC02870, AL031985.3, AC011476.3, AC012640.1, AL365361.1, LUCAT1, and prognostic features were established. We found that high-risk patients had poorer overall survival (OS) and progression-free survival (PFS) and higher mortality. Independent prognostic analysis, ROC, C-index and column line plot showed that amino acid metabolism-related lncRNAs could accurately predict the prognosis of patients. Column line plots and heat maps showed a significant difference in the distribution of amino acid metabolism-related lncRNAs between high- and low-risk groups. We also found that patients with high TMB had poorer OS, and the TIDE algorithm showed that high-risk patients had a greater likelihood of immune escape and poorer immunotherapy outcomes.

Conclusion

In conclusion, six lncRNAs associated with amino acid metabolism can accurately predict the prognosis of patients with hepatocellular carcinoma and may provide new insights for clinical application and treatment.
Carbon footprints of commodity field crops in global markets
Authors: Bamber Nicole , Turner Ian , Pelletier Nathan 
Published: November 2023

Abstract
Sustainability attributes are increasingly a source of competitive advantage for commodity crops in international markets, but fair comparisons are difficult given the diversity of agronomic environments and practices, complex supply chains, and heterogeneity in assessment methods and supporting data quality/availability. We adapted and applied a framework to transparently identify and source best available data, consistently model, and compare the carbon footprints of rapeseed, wheat and field peas produced in Canada, Australia, France, Germany and the United States. Canadian crops, especially those produced in the province of Saskatchewan, had much lower carbon footprints than the same crops produced in other countries when soil carbon changes were included and, in most cases, also when they were excluded. Transportation-to-market makes small contributions to global food system emissions, but is proportionately more important for low impact crops. For Saskatchewan crops, however, these emissions were more than offset by low production-related emissions in most cases.
Coproduction of cellulosic ethanol, lignosulfonate, and phenolic acids from an integrated corn cob valorization scheme
Authors: Maduzzi Julieta , Thomas Habila Yusuf , Fidelis José Dário Silva , de Carvalho José Valderisso Alfredo , Silva Elano Costa , Filho José Daladiê Barreto da Costa , Cavalcante José Demétrio Nery , Santos Everaldo Silvino dos , Souza Domingos Fabiano de Santana , Padilha Carlos Eduardo de Araújo 
Published: November 2023

Abstract
The economic competitiveness of 2G-bioethanol technology should improve through the use of by-products, especially lignin. The present study developed an integrated scheme to produce 2G-bioethanol, lignosulfonate, and phenolic acids from corncobs. Pretreatment with sulfuric acid made it possible to reduce the enzymatic dosage to 5 FPU/g in the enzymatic hydrolysis of samples with a size of less than 20 mesh. The addition of polyethylene glycol 1500 (PEG 1500) boosted the sugar release, reaching 56.73 g/L glucose under conditions with 20% (w/v) solids (gradual addition). In the ethanol production, the semi-simultaneous saccharification and fermentation strategy achieved a maximum production of 31.64 g/L in the condition with 5 FPU/g, 2% (w/w) PEG 1500, and 20% (w/v) solids (gradual addition). FTIR confirmed the preparation of lignosulfonate from fermentation residue, and the surfactant showed good stabilization performance in oil/water systems. Hydrogen peroxide promoted high yields of p-coumaric acid (8045.3 mg/100 g) and ferulic acid (1429.4 mg/100 g) in the alkaline hydrolysis of fermentation residue. Based on the results, corncob is versatile and can be used to create a biorefinery with high economic potential.
Surgical Self- steering Robot using Artificial Neural Network
Authors: Mahfouz Ahmed , Gamal Hassan El , Awad T. , Badawi M.B. 
Published: November 2023

Abstract
The aim of this work is to design a robot that can be used in surgery and can remove tumors by accurately and safely following contours. This is achieved by the medical imaging set such as DICOM-formatted images from several sources (CT, MRI, and Ultrasound) of these tumors using artificial neural networks. The workspace of a suggested 7 degrees of freedom robot is defined by calculating the position of the end effector for multiple positions of its links using DH tables and feed-forward kinematics. The data obtained are used to train three artificial neural networks to get the inverse kinematics. The suggested neural networks are the Generalized Regression Neural Network, Radial Basis, and Feed Forward. A training course for inverse kinematics of 23328 workspace points of the end effector of the suggested robot is used for training the three neural networks. The most accurately trained one was found to be the Feed-Forward neural network. It shows a root mean square error for those points of 2.08 mm and a training time of 1236 seconds and is to be applied to steer the robot links. The patient medical images are digitized using the image processing toolbox of MATLAB. The data obtained is to be fed to the superior neural network to get the robot links positions needed to move the end effector mounted with a cutter to follow the tumor contour accurately. The absolute error distance between the corresponding points of the contours resulting from testing the trained Feed-Forward NN with 51 points of a contour doesn’t exceed 2.08 mm.
Effect of pelvic position on ultrasonic measurement parameters of pelvic floor
Authors: Wang Yu , Zhuo Yan , Liu Min , Fang Jianqi , Weng Zongjie 
Published: November 2023

Abstract
Objective
To analyse the effect of pelvic position on ultrasonic measurement parameters of pelvic floor.
Methods
This study included 50 participants who visited Fujian Maternity and Child Health Hospital from May 2020 to May 2022. All participants were assessed by medical professionals for general information and Pelvic floor four dimensional ultrasound. Ultrasonic measurements were performed in three different positions of the pelvis (anterior pelvic tilt, posterior pelvic tilt, and neutral pelvic tilt) based on lithotomy position.
Results
Chi square test indicated that the differences in the diagnosis of urethral funnelling, cystocele, uterine prolapse, perineal overactivity, and hiatal ballooning among neutral position, anterior pelvic tilt, and posterior pelvic tilt were statistically significant (P = .008, P＜.001, P = .003, P＜.001, and P＜.001 respectively). Repeated ANOVA analysis showed that the difference among neutral position, anterior pelvic tilt, and posterior pelvic tilt in hiatal area (at contraction), hiatal area (at rest), hiatal area (at valsalva), bladder neck descent, urethral rotation angle, cervical descent, rectal ampulla descent, hiatal area increase, hiatal area decrease,cervical position (at rest), rectal ampulla position (at rest), bladder neck position(at valsalva), cervical position (at valsalva), and rectal ampulla position (at valsalva) were statistically significant (P < .001, P < .001, P < .001, P < .001, P = .001, P < .001, P < .001, P < .001, P < .001, P < .001, P < .001, P < .001, P < .001, and P < .001 respectively).
Conclusion
Participants perform pelvic floor muscle contraction and Valsalva maneuver better in posterior pelvic tilt than other positions. And posterior pelvic tilt thus became the position that the most pelvic organ prolapse were diagnosed.
A Late Pleistocene Hominin footprint site on the North African Coast of Morocco
Authors: Sedrati Mouncef , Morales Juan A. , Duveau Jérémy , M’rini Abdelmounim El , Mayoral Eduardo , Díaz‐Martínez Ignacio , Anthony Edward J. , Bulot Glen , Sedrati Anass , Gall Romain Le , Santos Ana , Rivera-Silva Jorge Jorge 
Published: November 2023

Abstract
Footprints represent a relevant vestige providing direct information on the biology, locomotion, and behaviour of the individuals who left them. However, the spatiotemporal distribution of hominin footprints is heterogeneous, particularly in North Africa, where no footprint sites were known before the Holocene. This region is important in the evolution of hominins. It notably includes the earliest currently known Homo sapiens (Jebel Irhoud) and the oldest and richest African Middle Stone Age (MSA) hominin sites. In this fragmented ichnological record, we report the discovery of 85 human footprints on a Late Pleistocene now indurated beach surface of about 2,800 m2 at Larache (Northwest coast of Morocco). The wide range of sizes of the footprints suggests that several individuals from different age groups made the tracks while moving landward and seaward across a semi-dissipative bar-trough sandy beach foreshore. A geological investigation and an Optically Stimulated Luminescence (OSL) dating of a rock sample extracted from the trackside places this hominin footprint surface at 90.3 ± 7.6 ka (MIS 5, Late Pleistocene). The Larache footprints are, therefore, the oldest attributed to Homo sapiens in Northern Africa and the Southern Mediterranean.
Exploring the Impact of Quality of Life and Social Support on Depression, Anxiety, and Stress in Sudanese Medical Students: A Cross-Sectional Study across Multiple Universities in Sudan
Authors: Amin Mohammed Hammad Jaber 
Published: November 2023

Abstract
Medical students are more likely to develop depression, burnout, and other mental health problems than people in the general population, and their mental health tends to decline over time as they progress through medical training. Several factors may contribute to anxiety in medical students, including academic pressure, work demands, social challenges, physical stressors, financial problems, and gender. We aimed in this study to determine the prevalence of depression, anxiety, and stress among Sudanese medical students, and to explore the impact of quality of life and social support on these three factors in Sudanese medical students across various universities in Sudan. Methodology : We did a cross sectional study in medical students of faculty of medicine in0000 governmental and private universities in Sudan, The data collection tool composed of three questionnaires: the MOS social support survey, English Depression, anxiety, and stress scale (DASS21), and English WHO quality of life brief WHOQOLB) questionnaire Results: The participants’ age ranged from 18 to 26(mean 22.60, SD 2.44, Median 22.47), with a male to female ration of almost 1:3, We can notice that more than half of respondents had different grades of depression, anxiety, and stress. We used analysis of variance (ANOVA) to test association between academic year and depression, anxiety, and stress. Table (4) demonstrates the mean. Median, and P values of the test the results showed that there was significant difference in the scores of anxiety and stress scales among students of different academic years also showed that the young students and final year students had higher level of stress and anxiety. Conclusion : A study found that over half of them experienced depression, anxiety, and stress. The study showed that the quality of environment and physical health were important factors contributing to these mental health issues. These factors explained a significant portion of the variance in depression, anxiety, and stress. Furthermore, the study discovered that anxiety and stress levels differed among students from different academic years, with younger and final year students experiencing higher levels of stress and anxiety.
Distribution, invasion history and ecology of non-native pine bark beetles (Coleoptera: Curculionidae: Scolytinae) in southern South America
Authors: Lantschner M. Victoria , Gomez Demian F. , Vilardo Gimena , Stazione Leonel , Ramos Sergio , Eskiviski Edgar , Fachinetti Romina , Schiappacassi Marcela , Vallejos Natalia , Germano Monica , Villacide José , Grilli Mariano P. , Martinez Gonzalo , Ahumada Rodrigo , Estay Sergio A. , Dumois Ignacio , Corley Juan 
Published: November 2023

Abstract
The growth of international trade, coupled with an expansion of large-scale pine plantations in South America during the second half of the 20th century, has significantly increased the opportunities for invasion of forest insects. Bark beetles (Coleoptera: Curculionidae, Scolytinae) are a large and diverse group of insects, commonly recognized as one of the most important tree mortality agents in coniferous forests worldwide and an important group among invasive forest species. In this study, we combined data from field sampling with published records of established non-native pine bark beetles, to describe their distribution and invasion history in pine plantations across southern South America, reviewing the available information on their phenology and host range. We obtained records of established populations of six Eurasian species distributed in two major regions: the southwest region comprises plantations in Chile and the Argentine Patagonia, with four bark beetle species: Hylurgus ligniperda, Orthotomicus laricis, Hylastes ater, and Hylastes linearis; the northeastern zone includes northeastern Argentina, Uruguay, and southern Brazil, includes three bark beetle species: H. ligniperda, Cyrtogenius luteus and O. erosus. The establishment of non-native populations across the study area began in the 1950s, and from the 1980s onwards, there has been an exponential increase in introductions. We predict that several of these species will continue spreading across South America, and that new species will continue arriving. We highlight the importance of international collaboration for early detection and management of non-native pine bark beetles.
The Psychological Experiences of Adolescent Suicide Attempt Patients : a systematic review of qualitative studies
Authors: Wang Xiaoning , Miao Qunfang , Li Jingyi , Zhu Li , Hu Tingting 
Published: November 2023

Abstract
Background: To systematically evaluate the psychological experiences of adolescent patients with suicide attempts and gain insight into their inner needs, with the aim of providing a theoretical basis for the development of targeted suicide crisis intervention strategies for adolescents with suicide attempts.
Methods: Computer searches of PubMed, Web of science, Embase, EBSCO, China Biomedical Database (CBM), China Knowledge Network, Wanfang Data, and Vipshop journal databases were conducted to include qualitative studies on the psychological experiences of adolescent patients with suicide attempts, with a search period from the date of database creation to April 1, 2023. The methodological quality of the included literature was evaluated using the Australian JBI Centre for Evidence-Based Health Care Quality Assessment Criteria for qualitative studies, and the results were integrated according to its pooled integration method.
Results: A total of 16 papers were included and 53 outcomes were distilled into 10 new categories and synthesized into 4 integrated outcomes:Factors in Suicide Attempts;The Diverse Motivations for Suicide; Self-Internal Transformations; Integrated Strategies for Coping with Suicide Attempts.
Conclusion: Adolescent patients with suicide attempts are affected by multiple factors, and healthcare professionals should strengthen protective factors for suicide attempts, enhance the prediction and intervention of suicide risk factors, pay attention to adolescent mental health education, adopt positive intervention strategies, provide multidimensional support for adolescents, encourage adolescents to establish positive self-perception and emotional expression skills, and inspire patients to reflect on the value of their own lives to reduce the risk of re-suicide.
Systematic review of registration platforms: PROSPERO
System review registration number: CRD42023417379
A machine learning approach for predicting the depression status among undergraduates: A case study from Sri Lanka
Authors: Sonnadara D.S. , Viswakula S.D. , Attygalle M.D.T 
Published: November 2023

Abstract
Background
Depression is a common mental health disorder that affects a significant portion of the global population. In Sri Lanka, depression is a growing concern, especially among undergraduate students. This study aims to develop a machine learning model to predict the depression status of science undergraduates from a state university in Sri Lanka
Methods
Data was collected from a sample of 363 undergraduates via a Google form which included the Patient Health Questionnaire-9 (PHQ-9) and several questions pertaining to their background. The data collected (through a convenience sampling scheme) was then used to build and evaluate 13 different machine learning models. The accuracy, precision and recall were used to evaluate the performance of each model.
Results
30% of the sample consisted of those who screened positive for depression. The results showed that the Gradient Boosting Classifier with an accuracy of 79% on the test set had the best accuracy as well as the best precision in predicting the depression status. Feature importance analysis identified the overall life satisfaction and level of stress associated with academic activities as the most important predictors of depression. Furthermore, the extent to which the respondents enjoy their university life, their BMI and whether or not they had nutritionally balanced diets were found to be the next three most important factors of depression status.
Conclusions
This study is possibly the first attempt to model and predict the depression status of Sri Lankan undergraduates using machine learning approaches. The developed model can be used as a screening tool to identify students who may be at risk of developing depression and can aid in providing targeted interventions to improve the mental health and well-being of undergraduates.
Medium-term outcomes of uncemented total hip arthroplasty in patients younger than 25 years old: A retrospective research
Authors: Yu Xin-Yuan , Qiao Yong-Jie , Li Xu-Sheng , Li Zi-Yao , Zhan Li-Rui , Song Xiao-Yang , Zhang Wen-Hua , Zhang Hao-Qiang 
Published: November 2023

Abstract
Objective: To evaluate the medium-term outcomes of uncemented total hip arthroplasty in patients ≤ 25 years.
Methods: A retrospective research was performed on patients ≤ 25 who received uncemented total hip arthroplasty at the Department of Orthopedics of the 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army from January 2009 to December 2018. The clinical evaluation was measured with modified Harris Hip Score, Western Ontario & McMaster Universities Osteoarthritis Index, and Short-Form 36. Postoperative complications (such as infection, revision, dislocation, and incisional healing issues) were recorded. Using pelvic anteroposterior, hip anteroposterior and lateral X-rays, the radiographic outcome was evaluated, including the position of the implants, loosening, bearing-surface wear, osteolysis, and heterotopic ossification. Loosening of the acetabular or femoral component or revision for any reason was defined as failure.
Results: At a follow-up of 8.3±2.4 years (range, 3.8 to 12 years), the preoperative modified Harris hip score was 43.5±12.9 (range, 18 to 62) and increased to 88.3 ± 8.8 (range, 72 to 97), and the preoperative postoperative Western Ontario & McMaster Universities Osteoarthritis Index score improved from 43.6±8.4 (range, 33.1 to 62.3) to 11.5 ± 6.8 (range, 2.5 to 25.8). The Physical Component score-SF-36 improved from 48.5 ± 8.6 (range, 36.4 to 61.3) to 81.2 ± 10.3 (range, 60.3 to 97.5), while the Mental Component score-SF-36 increased from 56.6±12.5 (range, 39.4 to 78.6) to 82.6 ± 12.9 (range, 54.7 to 97). The latest X-ray revealed that the position of the implants did not change substantially since the postoperative image. The abduction angle of acetabular cup was 41.8° ± 6.7° (range, 31° to 57°),the anteversion angle of acetabular cup was 18.2° ± 3.6° (range, 9.5° to 25.7°), and the filling ratio was 90.1% ± 3% (range, 85.2%-95.3%). The preoperative leg length discrepancy was 1.8 cm ± 0.8 cm (range, 1 cm to 5 cm) and reduced to 1.4 cm ± 0.5 cm (range, 0.5 cm to 2.5 cm). No considerable loosening, bearing-surface wear, osteolysis, or heterotopic ossification was observed. At the latest follow-up, the overall survival rate of the 49 hips was 98%.
Conclusion: For patients with end-stage hip disease under 25 years old, uncemented THA exhibit excellent outcomes, with a high survival rate and fewer complications at medium-term follow-up.
Will Nigella sativa oil protect parotid glands of rats against cranium gamma irradiation? Histological and immunohistochemical evaluation
Authors: Ahmed Salwa Farid , Bakr Mostafa A. 
Published: November 2023

Abstract
Background: Radiation plays an essential role in treating malignancies. Radiation exposure of salivary glands often results in permanent loss of their functions; therefore, their protection against radiation is crucial. Nigella sativa oil (NSO) is a useful antioxidant against free radicals. The purpose of this study was to investigate the radio-protective effect of NSO on oxidative injury of parotid glands of gamma-irradiated rats.
Methods: Twenty-eight male albino rats were divided into four groups (n= 7): Group 1: Neither NSO nor radiation, Group 2: Rats received NSO 400 mg/kg, Group 3: Rats received 15 Gy cranium gamma‑irradiation & Group 4: Rats received gamma irradiation and NSO. Rats were sacrificed two weeks after the last NSO dose. Histological sections of parotid glands were stained with H&E, Masson’s trichrome and anti-TGF-β antibodies. Area percentage of Masson’s trichrome and TGF-β expression was morphometrically examined.
Results: Parotid glands of control and NSO groups revealed normal morphology. Gamma-irradiated glands showed loss of normal acinar architecture and slight acinar shrinkage. NSO treatment of gamma-irradiated glands preserved acinar outline and architecture. Masson’s trichrome stained samples revealed trace amounts of collagen fibers in control and NSO groups, and excessive amounts of collagen fibers in gamma-irradiated group, in addition to few collagen fibers for gamma-irradiated glands treated with NSO. Additionally, control and NSO groups showed negative TGF-β expression. Gamma-irradiated group showed high TGF-β expression, while NSO treated gamma-irradiated group showed moderate TGF-β expression.
Conclusions: Gamma-irradiation adversely affected parotid glands, and in contrast, NSO seemed to positively counteract this adverse effect.