bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of Pharmacist Prescribing for Managing Hypertension in the United States
Authors: Dixon Dave L. , Johnston Karissa , Patterson Julie , Marra Carlo A. , Tsuyuki Ross T. 
Published: November 2023

ImportancePharmacist-led interventions can significantly improve blood pressure (BP) control. The long-term cost-effectiveness of pharmacist-prescribing interventions implemented on a large scale in the US remains unclear.ObjectiveTo estimate the cost-effectiveness of implementing a pharmacist-prescribing intervention to improve BP control in the US.Design, Setting, and ParticipantsThis economic evaluation included a 5-state Markov model based on the pharmacist-prescribing intervention used in The Alberta Clinical Trial in Optimizing Hypertension (or RxACTION) (2009 to 2013). In the trial, control group patients received an active intervention, including a BP wallet card, education, and usual care. Data were analyzed from January to June 2023.Main Outcomes and MeasuresCardiovascular (CV) events, end-stage kidney disease events, life years, quality-adjusted life years (QALYs), lifetime costs, and lifetime incremental cost-effectiveness ratio (ICER). CV risk was calculated using Framingham risk equations. Costs were based on the reimbursement rate for level 1 encounters, medication costs from published literature, and event costs from national surveys and pricing data sets. Quality of life was determined using a published catalog of EQ-5D utility values. One-way sensitivity analyses were used to assess alternative reimbursement values, a reduced time horizon of 5 years, alternative assumptions for BP reduction, and the assumption of no benefit to the intervention after 10 years. The model was expanded to the US population to estimate population-level cost and health impacts.ResultsAssumed demographics were mean (SD) age, 64 (12.5) years, 121 (49%) male, and a mean (SD) baseline BP of 150/84 (13.9/11.5) mm Hg. Over a 30-year time horizon, the pharmacist-prescribing intervention yielded 2100 fewer cases of CV disease and 8 fewer cases of kidney disease per 10 000 patients. The intervention was also associated with 0.34 (2.5th-97.5th percentiles, 0.23-0.45) additional life years and 0.62 (2.5th-97.5th percentiles, 0.53-0.73) additional QALYs. The cost savings were $10 162 (2.5th-97.5th percentiles, $6636-$13 581) per person due to fewer CV events with the pharmacist-prescribing intervention, even after the cost of the visits and medication adjustments. The intervention continued to produce benefits in more conservative analyses despite increased costs as the ICER ranged from $2093 to $24 076. At the population level, a 50% intervention uptake was associated with a $1.137 trillion in cost savings and would save an estimated 30.2 million life years over 30 years.Conclusion and RelevanceThese findings suggest that a pharmacist-prescribing intervention to improve BP control may provide high economic value. The necessary tools and resources are readily available to implement pharmacist-prescribing interventions across the US; however, reimbursement limitations remain a barrier.
Task space control of the robot manipulators with adaptive fuzzy global fast terminal sliding mode control in presence of dynamic and kinematic uncertainties
Authors: Soltanpour Mohammad Reza , Zaare Saeed 
Published: November 2023

SummaryBasic features such as convergence time and speed, number‐action control coefficients, free chattering, and proof of stability are significant in the design process and sliding mode control (SMC) efficiency. In this article, we propose an adaptive fuzzy global fast terminal SMC (AFGFTSMC) to handle the mentioned features in the task space control of the robot manipulator in the presence of dynamic and kinematic uncertainties. First, perturbed joint space dynamic equations of the system are transferred to task space, and a broad range of uncertainties are considered there. Then, a global fast terminal SMC (GFTSMC) is proposed for robot manipulators in task space, in which a flexible sliding surface improves the convergence time. Next, to have an intelligent adjustment of the sliding surface coefficients, which leads to a much faster convergence rate, a fuzzy approximator with just seven fuzzy rules is presented. In the following, to access the boundaries of the existing uncertainties, an adaptive fuzzy approximator is proposed, which has five fuzzy rules and only one adaptive law, increases the system's robustness, and eliminates the effect of chattering. Mathematical proof shows that the task space closed‐loop control system under the proposed AFGFTSMC and in the presence of dynamic and kinematic uncertainties has a finite‐time global asymptotic stability. The theoretical evidence and simulation results, which are conducted on a 2‐link robot manipulator, confirm the good efficiency of the proposed controller.
Highly Stretchable and Conductive MXene‐Encapsulated Liquid Metal Hydrogels for Bioinspired Self‐Sensing Soft Actuators
Authors: Ma Shaoshuai , Xue Pan , Valenzuela Cristian , Zhang Xuan , Chen Yuanhao , Liu Yuan , Yang Le , Xu Xinhua , Wang Ling 
Published: November 2023

AbstractAdvanced sensation and actuation abilities of various living organisms in nature have inspired researchers to design bioinspired self‐sensing soft actuators. However, the majority of conventional soft actuators primarily possess actuation capabilities while lacking a real‐time sensing signal feedback. Here, a promising strategy is reported to develop highly stretchable and conductive hydrogels for bioinspired self‐sensing soft actuators, which integrate actuation and strain‐sensing functions into a single materials system. The conductive hydrogels are designed and fabricated by in situ copolymerization of amino‐functionalized MXene‐encapsulated liquid metal nanodroplets (LM@A‐MXene) and poly(N‐isopropylacrylamide) hydrogels with controllable activated nanogels as nano‐cross‐linkers. The resulting hydrogel presents a compacted conducting network and highly porous microstructure, giving rise to robust integration of high conductivity, excellent strain sensitivity, broad stretchability, high stability, and fast response speed. Interestingly, the gradient network structure, formed by self‐precipitation of LM@A‐MXene, endows the hydrogel with shape‐programmable actuation, light‐driven remote control, and self‐sensing function. As a proof‐of‐concept application, the soft gripper based on the self‐sensing hydrogel actuators is developed, which can not only grasp, lift, and release objects, but also perceive every movement state by monitoring resistance changes. The proposed self‐sensing soft actuator can offer new insights for developing smart soft robotics and other artificial intelligent devices.
Scalable Production of Robust and Tough Biomimetic Composite by Rapid In‐Situ Mineralization
Authors: Qiu Zhe , Lang Lizhong , Yu Zhengyang , Zhu Jiaying , Ye Yuhang , Zou Yu , Xie Yanjun , Jiang Feng 
Published: November 2023

AbstractNacre‐inspired materials with combined high strength and toughness have been widely developed and utilized for various engineering applications. However, existing preparation techniques suffer from intricate processes, high energy‐consumption, and lack of scalability, all of which collectively impede the efficient production of three‐dimensional materials. Here, a viable strategy is reported for the efficient and scalable production of bulk nacre‐mimetic materials, drawing inspiration from the intricate structures found in both nacre and wood. The prepared millimeter‐thick wooden artificial nacres (WANs) exhibit the presence of multi‐hierarchical lamellar structures, organic bridges, and micro‐asperities. Those features lead to the WANs exhibiting impressive mechanical performances, presenting excellent bending strength (≈93.31 MPa), toughness (≈7.40 MPa m1/2), tensile strength (≈122.59 MPa), and work of fracture (≈4.61 MJ m−3). In addition, owing to the low density (≈1.59 g cm−3), the WANs show much higher specific mechanical properties compared to nacre and related artificial nacre materials. Considering both its production process and exceptional properties, this material holds great promise for practical applications within the realm of engineering and structural fields.
Liquid as Plasma Mask for Constructing Arbitrary Area with Contrary Wettability on Hydrophobic Textiles
Authors: Yang Linfeng , Hao Dezhao , He Zengyi , Sun Junhan , Feng Yaping , Dai Haoyu , Jiang Lei 
Published: November 2023

AbstractMaterials with contrary wettability have various functions and applications. Common methods such as chemical modification and secondary treatment with solid mask to achieve relevant wettability either have harmful additives or construct fixed shape. Herein, liquid is introduced as a plasma mask for constructing arbitrary area with contrary wettability on hydrophobic textiles. In atmospheric plasma working region, exposed area of textiles achieves hydrophilic while liquid shielding area maintains the original wettability. Water–ethanol mixtures with a broad range of surface tension are chosen as template liquid to meet most hydrophobic textiles with the property of erasable evaporation without residue. Liquid mask with fluidity can be drawn in any shape at any time, meanwhile, plasma treatment highlights the merit of no chemical additive. Higher resolution will be achieved when the operation process is further refined. This study may provide insights for constructing advanced infiltrating materials and replacing solid with liquid in more application scenarios.
Au Nanocrystals Modified Holey PtTeAu Metallene Heteronanostructures for Plasmon‐Enhanced Nitrate Electroreduction
Authors: Hong Qing‐Ling , Sun Bin , Ai Xuan , Tian Xin‐Long , Li Fu‐Min , Chen Yu 
Published: November 2023

AbstractAmmonia (NH3) is an essential chemical for agricultural production and a promising next‐generation hydrogen‐rich fuel. The electrocatalytic nitrate (NO3−) reduction reaction (NO3RR) to NH3 provides a sustainable and low‐energy method to replace industrial NH3 synthesis. However, the NO3− to NH3 conversion is limited by the complex eight‐electron and nine‐proton reduction processes, thus it is highly desirable to develop efficient electrocatalytic materials to overcome the kinetic barrier of NO3RR. Herein, Au nanocrystals (Au‐NCs) modified holey PtTeAu metallene (PtTeAu‐ML) heteronanostructures (Au‐NCs/PtTeAu‐MLs) are designed through phase and interface engineering, which achieve the high NH3 yield (3.499 mg h−1 mgcat−1) and Faradaic efficiency of 96.3% for NO3RR at −0.03 V versus RHE. Detailed investigations reveal that the introduction of Te atoms significantly inhibits the high activity of Pt atoms for hydrogen evolution reaction that competes with NO3RR. Density functional theory results demonstrate that Au atoms further modulate the electronic structure of Pt in PtTe‐MLs, resulting in the upward shifted d band center of Pt and in turn the optimized NO3RR process on PtTeAu‐MLs. Furthermore, Au‐NCs allows the sustainable sunlight energy to accelerate the NO3RR kinetics at PtTeAu‐MLs because of the localized surface plasmon resonance of Au, inducing a higher NH3 yield of 4.684 mg h−1 mgcat−1 under light irradiation condition.
Mesenchymal Stem Cell‐Derived Mitochondria Enhance Extracellular Matrix‐Derived Grafts for the Repair of Nerve Defect
Authors: Bai Jun , Yu Bingbing , Li Chaochao , Cheng Haofeng , Guan Yanjun , Ren Zhiqi , Zhang Tieyuan , Song Xiangyu , Jia Zhibo , Su Tianqi , Tao Benzhang , Gao Haihao , Yang Boyao , Liang Lijing , Xiong Xing , Zhou Xingyu , Yin Lan , Peng Jiang , Shang Aijia , Wang Yu 
Published: November 2023

AbstractPeripheral nerve injuries (PNI) can lead to mitochondrial dysfunction and energy depletion within the affected microenvironment. The objective is to investigate the potential of transplanting mitochondria to reshape the neural regeneration microenvironment. High‐purity functional mitochondria with an intact structure are extracted from human umbilical cord‐derived mesenchymal stem cells (hUCMSCs) using the Dounce homogenization combined with ultracentrifugation. Results show that when hUCMSC‐derived mitochondria (hUCMSC‐Mitos) are cocultured with Schwann cells (SCs), they promote the proliferation, migration, and respiratory capacity of SCs. Acellular nerve allografts (ANAs) have shown promise in nerve regeneration, however, their therapeutic effect is not satisfactory enough. The incorporation of hUCMSC‐Mitos within ANAs has the potential to remodel the regenerative microenvironment. This approach demonstrates satisfactory outcomes in terms of tissue regeneration and functional recovery. Particularly, the use of metabolomics and bioenergetic profiling is used for the first time to analyze the energy metabolism microenvironment after PNI. This remodeling occurs through the enhancement of the tricarboxylic acid cycle and the regulation of associated metabolites, resulting in increased energy synthesis. Overall, the hUCMSC‐Mito‐loaded ANAs exhibit high functionality to promote nerve regeneration, providing a novel regenerative strategy based on improving energy metabolism for neural repair.
Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing
Authors: Wang Yu , Guo Jiahui , Luo Zhiqiang , Shen Yingbo , Wang Jinglin , Yu Yunru , Zhao Yuanjin 
Published: November 2023

AbstractHydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treating diabetes wounds are presented. Such microfibers are continuously generated by one‐step microfluidic spinning technology with acetic acid solution of prolamins as the continuous phase and deionized water as the dispersed phase. By adjusting the prolamin concentration and flow rates of microfluidics, the porous structure and morphology as well as diameters of microfibers can be well tailored. Owing to their porosity, the resultant microfibers can be employed as flexible delivery systems for wound healing actives, such as bacitracin and vascular endothelial growth factor (VEGF). It is demonstrated that the resultant hydrogel microfibers are with good cell‐affinity and effective drug release efficiency, and their woven patches display superior in vivo capability in treating diabetes wounds. Thus, it is believed that the proposed prolamins‐assembled porous hydrogel microfibers will show important values in clinic wound treatments.
Reconstruction of Vesicle Assemblies with DNA Nanorulers for Resolving Heterogeneity of Vesicles in Live Cells
Authors: Zhang Yueyue , Liu Jiangbo , Mao Xiuhai , Fan Hongxuan , Li Fan , Wang Shaopeng , Li Jiang , Li Min , Zuo Xiaolei 
Published: November 2023

AbstractNanoscale vesicles such as synaptic vesicles play a pivotal role in efficient interneuronal communications in vivo. However, the coexistence of single vesicle and vesicle clusters in living cells increases the heterogeneity of vesicle populations, which largely complicates the quantitative analysis of the vesicles. The high spatiotemporal monitoring of vesicle assemblies is currently incompletely resolved. Here, this work uses synthetic vesicles and DNA nanorulers to reconstruct in vitro the vesicle assemblies that mimic vesicle clusters in living cells. DNA nanorulers program the lateral distance of vesicle assemblies from 3 to 10 nm. This work uses the carbon fiber nanoelectrode (CFNE) to amperometric monitor artificial vesicle assemblies with sub‐10 nm interspaces, and obtain a larger proportion of complex events. This work resolves the heterogeneity of individual vesicle release kinetics in PC12 cells with the temporal resolution down to ≈0.1 ms. This work further analyzes the aggregation state of intracellular vesicles and the exocytosis of living cells with electrochemical vesicle cytometry. The results indicate that the exocytosis of vesicle clusters is critically dependent on the size of clusters. This technology has the potential as a tool to shed light on the heterogeneity analysis of vesicle populations.
Bottom‐Up Magnesium Deposition Induced by Paper‐Based Triple‐Gradient Scaffolds toward Flexible Magnesium Metal Batteries
Authors: Bi Jingxuan , Liu Yuhang , Du Zhuzhu , Wang Ke , Guan Wanqing , Wu Haiwei , Ai Wei , Huang Wei 
Published: November 2023

AbstractThe development of advanced magnesium metal batteries (MMBs) has been hindered by longstanding challenges, such as the inability to induce uniform magnesium (Mg) nucleation and the inefficient utilization of Mg foil. This study introduces a novel solution in the form of a flexible, lightweight, paper‐based scaffold that incorporates gradient conductivity, magnesiophilicity, and pore size. This design is achieved through an industrially adaptable papermaking process in which the ratio of carboxylated multi‐walled carbon nanotubes to softwood cellulose fibers is meticulously adjusted. The triple‐gradient structure of the scaffold enables the regulation of Mg ion flux, promoting bottom‐up Mg deposition. Owing to its high flexibility, low thickness, and reduced density, the scaffold has potential applications in flexible and wearable electronics. Accordingly, the triple‐gradient electrodes exhibit stable operation for over 1200 h at 3 mA cm−2/3 mAh cm−2 in symmetrical cells, markedly outperforming the non‐gradient and metallic Mg alternatives. Notably, this study marks the first successful fabrication of a flexible MMB pouch full cell, achieving an impressive volumetric energy density of 244 Wh L−1. The simplicity and scalability of the triple‐gradient design, which uses readily available materials through an industrially compatible papermaking process, open new doors for the production of flexible, high‐energy‐density metal batteries.
Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery
Authors: Chandra Dilip Kumar , Reis Rui L. , Kundu Subhas C. , Kumar Awanish , Mahapatra Chinmaya 
Published: November 2023

AbstractCarbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio‐chemical features such as huge surface area, tunable side wall, and microneedle‐like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non‐covalent functionalization) result in the formation of functionalized CNTs (F‐CNTs) and CNT‐based hybrid materials (CNT‐HMs). These F‐CNTs and CNT‐HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio‐barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F‐CNT and CNT‐HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT‐HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.
Polyethylene Glycol‐Stabilized Gold Nanostars‐Loaded Microneedles for Photothermal Therapy of Melanoma
Authors: El‐Sayed Nesma , Elbadri Khalil , Correia Alexandra , Santos Hélder A. 
Published: November 2023

AbstractGold nanostars (GNSs) as a photothermal agent have shown great potential for the treatment of cancers like melanoma. Irradiation of the photothermal agents with light of a suitable wavelength generates heat that induces cellular stress and protein denaturation in cancer cells. The delivery of GNSs to skin using fast dissolving microneedles (MNs) presents a promising approach for painless and convenient administration of the therapy. In this study, polyethylene glycol (PEG) stabilized GNSs able to absorb light in the near‐infra red region and release heat (up to 65 °C, room temperature) are developed. The cytotoxicity of these nanoparticles is assessed before and after exposure to laser irradiation. GNSs show an instant lethal photothermal effect when tested on B16F10 melanoma cells upon irradiation with 808 nm at a power of 800 mW for 10 min. Loading the GNSs in polyvinylpyrrolidone (PVP) MNs preserves the photothermal effect of GNS and the mechanical properties of MNs. GNS‐loaded PVP MNs show efficient piercing in excised porcine skin, fast dissolution in 3 min after insertion and elevation of the skin temperature after laser irradiation (808 nm, 800 mW, 10 min) to 63 °C. Consequently, PEG‐stabilized GNSs and PVP MNs are a promising platform for photothermal therapy in melanoma treatment.
Waste to Wealth Approach: Customizing Spent LiB Anodes to High Performance Supercapacitor Electrode
Authors: Prakash Subramani , Sandhiya Murugesan , Kamarsamam Jawaharali , Ganesan Mahadevan , Sathish Marappan 
Published: November 2023

AbstractLithium‐ion batteries (LiBs) are widely used in various applications because of their high energy density, low self‐discharge rate, and portability. The requirements for LiBs continue to increase drastically every year; however, the disposal of spent LIBs is a cumbersome task. To resolve this issue, spent LiB anodes are customized into high‐performance supercapacitor (SC) electrodes via supercritical water exfoliation. The specific capacitance of spent LiB anodes (289 F g−1 at 2 A g−1) significantly improved after exfoliation (351 F g−1 at 2 A g−1). Furthermore, the electrochemical performance of the exfoliated LiB anode mushroomed upon the addition of dopamine (as a redox‐additive for the first time) with a conventional H2SO4 electrolyte. The specific capacitance of the exfoliated LiB anode is incredibly improved after the addition of dopamine with H2SO4, from 286 to 571 F g−1 at 4 A g−1. A flexible SC is also fabricated using PVA/H2SO4 and dopamine/PVA/H2SO4 as the gel electrolyte. The fabricated flexible SC with dopamine/PVA/H2SO4 exhibited an enormously high energy density of 44 Wh kg−1 at 700 W kg−1. The increased specific capacitance and energy density of the SC after the addition of dopamine with H2SO4 and PVA/H2SO4 may be due to the reversible reaction of dopamine to dopamine‐o‐quinone with H+ ions.
Room Temperature Exsolution of Cds Nanodots on A‐site Deficient Cotton‐Ball Like Titanate Perovskite Nanoparticles for H2 Production Under Visible Light
Authors: Chattopadhyay Shreyasi , Naden Aaron B , Skinner William S. J. , Kerherve Gwilherm , Payne David J , Irvine John T. S. 
Published: November 2023

AbstractExsolution of nanoparticles followed by chemical treatment (“chemistry at a point”) is a very exciting approach to the smart design of functional materials such as visible light active photocatalysts. Unfortunately, the usually utilized thermal reduction approach is not feasible for low melting point metals and compounds such as Cd and CdO. Here a hydrothermal approach to prepare exsolved CdS nanodots on cotton ball‐like perovskite supports is described. The titanate‐based photocatalyst is synthesized using a hydrothermal process followed by room‐temperature sulfidation. The hydrothermal route directs A‐site doping of Cd2+ via hydroxyl group incorporation in the titanate lattice. Formation of CdS via exsolution provides a high H2 production mass activity of 3050 µmol g−1 h−1 under visible light with only 5 mol.% Cd doping of the titanate. Moreover, the strong CdS‐support interaction offers good cycling stability under UV–vis and visible light irradiation. This is the first report describing the exsolution of CdS nanodots at room temperature and shows its advantages for photocatalytic activity.