bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in food preferences after oral semaglutide administration in Japanese patients with type 2 diabetes: KAMOGAWA-DM cohort
Authors: Hironaka Junya , Ushigome Emi , Kondo Yuriko , Hashimoto Yoshitaka , Osaka Takafumi , Majima Saori , Nakanishi Naoko , Okada Hiroshi , Senmaru Takafumi , Hamaguchi Masahide , Yamazaki Masahiro , Fukui Michiaki 
Published: January 2025

Background This study aimed to investigate the effects of oral semaglutide on the changes in food preference of Japanese patients with type 2 diabetes. Methods This retrospective multicenter study included 75 patients with type 2 diabetes who received oral semaglutide. The primary outcome was the change in the score of brief-type self-administered diet history questionnaire (BDHQ) score 3 months after the initiation of oral semaglutide treatment. The secondary outcome was the change in the Control of Eating Questionnaire (CoEQ), HbA1c, and body mass index (BMI) after 3 months. Results The median age, BMI, and HbA1c of the 23 participants were 64.0 years, 26.9 kg/m2, and 7.6% (59 mmol/mol). The BDHQ results showed total energy was significantly reduced. Among the individual nutrients, carbohydrates most decreased. The CoEQ results particularly showed declines in cravings for something sweet, chocolate or chocolate flavored foods, and starchy foods, satisfaction at meals, frequency and intensity of food craving, difficulty of resisting the craving for food, and frequency of eating in response to cravings for food were significantly lower after 3 months. The mean HbA1c and BMI significantly decreased. Conclusions In Japanese patients with type 2 diabetes, oral semaglutide treatment decreased total energy intake and changed food preferences.
The experience of adults with cystic fibrosis using long-term domiciliary non-invasive ventilation
Authors: Choyce Jocelyn , Hewison Alistair , Swift Amelia , Whitehouse Joanna L 
Published: January 2025

Background: The use of non-invasive ventilation (NIV) in patients with advanced cystic fibrosis (CF) has increased in recent years. Research evidence supports its clinical benefits, but less is known about the patients’ experience of its long-term use in a domiciliary setting. Objective: To investigate patients’ lived experience of using long-term domiciliary NIV. Methods: Semi-structured, qualitative interviews were conducted with adults with CF using long-term domiciliary NIV for respiratory failure. The data collected were subject to thematic analysis. Results: Nine adults (6 female), 5 of whom were awaiting lung transplantation, with a mean age of 39 years and mean FEV1 per cent predicted of 28%, were recruited. Data analysis revealed 2 themes: gratitude, and determination despite challenges. Patients identified some troubling side effects from NIV but were grateful for its symptomatic relief and were determined to continue using it to improve their quality of life. Conclusions: Participants reported experiences of NIV to be generally positive in terms of symptom relief and quality of life. These findings provide an initial insight into patients’ experience of NIV and have the potential to help guide and improve care.
The Impact of Surgeon Experience—Consultant Versus Supervised Trainees After Elective Infrarenal EVAR: Short-term to Mid-term Outcomes
Authors: Ribeiro Tiago F , Fidalgo Helena , Soares Ferreira Rita , Amaral Carlos , Bastos Gonçalves Frederico , Ferreira Maria Emília 
Published: January 2025

Introduction: Vascular trainees are required to have a comprehensive training program, encompassing the completion of clinical, surgical, and research tasks. To fulfill their surgical abilities and performance, sufficient supervised operating time is mandatory. After open vascular procedures, it has been observed that trainee involvement does not lead to detrimental outcomes. On the contrary, its impact during endovascular procedures, which require distinct technical skills, is scarcely reported. The authors aim to analyze the impact of primary operator experience on the outcomes of elective infrarenal endovascular aneurysm repair (EVAR) performed within a teaching institution over a 14-year period. Methods: This is a single-center, retrospective, comparative study. All consecutive patients submitted to elective EVAR (2011-2023) were considered. Two groups were defined: supervised trainee (ST) and consultant (C), according to the experience of the primary operator. The primary outcome was the incidence of 30-day major adverse events (MAEs). The secondary outcomes were contrast usage, operative time, bleeding, length of stay (LOS), return to operating room (OR), and freedom from aortic-related interventions up to 2 years. Results: Overall, 507 patients were included (62.1% ST vs 32.5% C). Seventy-two MAEs occurred in 8.1%, with no differences across groups (7.0% ST vs 9.9% C, p=0.31, adjusted odds ratio [aOR]=0.94, 95% confidence interval [CI]=0.46-1.91 for ST-performed procedures), even when MAE components were depicted individually. After adjustment for confounders, no significant differences were found in contrast usage ≥120 mL (aOR=0.89, 95% CI=0.50-1.56), operative time ≥160 minutes (aOR=0.73, 95% CI=0.45-0.18), bleeding (aOR=1.13, 95% CI=0.60-2.12), intensive care unit admission (aOR=0.68, 95% CI=0.40-1.17), prolonged LOS (aOR=0.93, 95% CI=0.60-1.43), return to OR (aOR=0.91, 95% CI=0.37-2.20), and mid-term freedom from aortic-related interventions (adjusted hazard ratio [aHR]=1.39, 95% CI=0.69-2.79). Conclusion: In carefully selected cases, elective EVAR performed by supervised trainees seems as safe and effective at mid-term as operations performed by consultants. These findings may have important implications for training programs. Further studies to confirm and clarify our findings are required. Clinical Impact In carefully selected cases, elective EVAR performed by supervised trainees seems safe, when compared to operations performed by consultants. Short-term major adverse events, contrast usage, operative time, bleeding, secondary interventions and length of stay appear similar. Mid-term freedom-from aortic interventions is comparable. These findings may have important implications for vascular training programs.
Endovascular Coiling Combined With Tissue Glue Embolism to Treat 20 Cases of Iliac Arteriovenous Fistula Secondary to Deep Vein Thrombosis
Authors: Liu Zhengli , Zhao Boxiang , Gu Jianping , Wang Tao , Gong Maofeng , Su Haobo , He Xu , Kong Jie 
Published: January 2025

Objective: The objective of this study is to assess the feasibility of endovascular coiling combined with tissue glue embolism for the treatment of iliac arteriovenous fistula (AVF) secondary to deep vein thrombosis (DVT) of the lower extremities. In addition, we aim to summarize the treatment methods and enhance understanding of the disease. Methods: This research analyzes the clinical data and medical imaging materials of 20 cases with iliac AVF secondary to lower extremity DVT, ranging from December 2014 to December 2020, at our hospital. The patients underwent endovascular coiling and tissue glue embolism during their hospital stay. We collected and summarized the clinical and imaging data, evaluated the efficacy of treatment methods, assessed the incidence of complications, and conducted long-term follow-up observations. Results: All 20 surgeries were successful. Endovascular coiling combined with tissue glue embolism significantly relieved limb swelling. The diameter difference above the patella in patients before and after treatment was 9.38±3.58 versus 4.13±1.64 cm, P<0.001. No serious complications occurred during treatment, and no patients showed signs of AVF recurrence during follow-up after surgery. Conclusion: Endovascular coiling combined with tissue glue embolism can be used to treat iliac AVF secondary to DVT of the lower extremities, which has high clinical value and is safe. Clinical Impact For clinicians, AVF secondary to DVT is a complication that cannot be ignored. It also needs to be treated aggressively to improve patients’ quality of life. We presented a minimally invasive method to treat iliac arteriovenous fistula secondary to deep vein thrombosis of lower extremities, which is also an innovative intervention technique. Endovascular coiling combined with tissue glue embolism can achieve better embolic blockade in this type of iliac arteriovenous fistula. This will move the management of postoperative complications in the direction of minimally invasive.
Evaluation of anti-vibration properties in work gloves using novel 3D knitted padding
Authors: Wang Yi-Lei , Chen He-Rong , Yu Annie , Masuda Arata , Takeuchi Shunji 
Published: January 2025

Elastomeric materials are commonly used as the padding of anti-vibration gloves for damping purposes. This study investigates the use of a breathable 3D knitted padding for vibration isolation in anti-vibration gloves. Sixteen (16) knitted fabric samples with different spacer structures, silicone inlay patterns, and inlay materials are produced to evaluate their effect on vibration transmissibility for a frequency range of 0-1000 Hz according to ISO13753:2008. The samples with the spacer structure that shows the best vibration isolation performance are made into the paddings for an anti-vibration glove which is then compared with four commercially available anti-vibration gloves in terms of vibration transmissibility based on ISO10819:2013. The results show that a thicker spacer structure with a larger number of needles in between the tuck stitches and inlaid with silicone hollow tubes can better isolate vibration. The vibration isolation performance of the 3D knitted fabric padded glove outperforms two commercially available gloves, though it falls short of the certified options. The findings show the possibility of using 3D knitted fabric as padding for anti-vibration gloves. However, further improvements to the glove and fabric design are needed to enhance the function and effectiveness of the glove. The development of lightweight breathable knitted padding can promote the wearing comfort of anti-vibration gloves which benefits the workers using vibrating hand tools and advances the development of personal protection equipment.
Preoperative Ultrasound Correctly Localized Peripheral Nerve Abnormalities for Operative Guidance: A Retrospective Review
Authors: Cha Noah , Zusstone Esther , Ko Lydia , Lee Steve K. , J. Milani Carlo , Feinberg Joseph H. , Wolfe Scott W. , Nwawka O. Kenechi 
Published: January 2025

Background: Correct localization and characterization of nerve abnormality is of critical importance to appropriate intervention. Ultrasound (US) is known to be accurate in the diagnosis of peripheral neuropathy and in preoperative localization of nerve abnormalities and skin marking. Purpose: We sought to investigate the utility of US-guided preoperative skin marking for the localization of peripheral nerve abnormality and to compare the US findings to electrodiagnostic (EDx) reports. Methods: Using the radiology information system at a single institution, we identified US examinations performed for preoperative localization of peripheral nerve abnormality from July 2016 to March 2023. Data collected included US characterization, surgical description, and EDx report of neuropathy. Results: Search parameters identified 67 nerves in 55 patients treated surgically after US-guided localization of the nerve with skin marking. The EDx characterization was performed in 36 (54%) of these cases. The US diagnoses included neuroma, transection, perineural scarring, hardware impingement, and intraneural fascicular constriction. There was 100% accuracy of US findings as confirmed by operative notes. Skin marking by US guidance correlated to the sites of the nerve documented in operative reports of all 67 cases. Conclusion: In this single-institution retrospective review, US-guided preoperative skin marking of nerve abnormality was used to correctly localize peripheral nerve abnormality, and US diagnoses were corroborated by intraoperative findings. Further higher-level study is needed to support these findings suggesting the efficacy of US in mapping the course of peripheral nerves.
The impact of pre-treatment aneurysm angulation. What happens with WEB devices at follow-up?
Authors: Muñoz Romina , Dazeo Nicolás , García Camila , Janot Kevin , Bankole Nourou Dine Adeniran , Narata Ana Paula , Rouchaud Aymeric , Larrabide Ignacio 
Published: January 2025

Background WEB shape modification has been analyzed in relation to the aneurysm occlusion outcome and techniques have been presented with one-dimensional measurements of the device to quantify the change after implantation. In this work, we present an analysis of pre-treatment vascular morphology and hemodynamics of cases treated with WEB devices, which were three-dimensionally quantified in morphology and position to detect modifications. Methods Seventeen WEB-treated aneurysms with pre-treatment, post-treatment and follow-up 3D flat-panel CT were included. Three-dimensional measurements of the WEB morphology and position were made at post-treatment and at follow-up. Differences between acquisitions of all measured variables were statistically evaluated (Wilcoxon signed-rank paired test, P-value = 0.05). Pre-treatment aneurysm angles were three-dimensionally measured and CFD simulations were performed to evaluate the influence of flow on WEB changes. Results WEB height and diameter presented statistically significant changes. Modification of the angle between the WEB axis and parent artery was significantly higher in the group with WEB shape modification (Mann-Whitney U test, P < 0.05). In this group, the median pre-treatment aneurysm angle was smaller than in the group without shape modification (8.16° vs. 13.14°, P = 0.06). Inflow ratio was higher in the WEB shape modification group. Conclusions An association between the magnitude of morphological changes of the WEB with the direction of its axis within the aneurysm was found. The analysis of pre-treatment morphological and hemodynamic conditions would allow the detection of aneurysm cases in which the WEB will undergo a more pronounced modification.
Vaccination coverage and its determinants in patients with multiple sclerosis—a multicenter cross-sectional study
Authors: Schade Paula , Nguyen Hai-Anh , Steinle Julia , Hellwig Kerstin , Pelea Teodor , Franken Philipp , Elias-Hamp Birte , Becker Veit , Merkelbach Stefan , Richter Stephan , Wagner Bert , Geis Christian , Schwab Matthias , Rakers Florian 
Published: January 2025

Background: Complete vaccination coverage is recommended by multiple sclerosis (MS) societies for patients with multiple sclerosis (pwMS) to mitigate infection risks associated with disease-modifying therapies (DMTs). Objectives: To analyze vaccination coverage and its determinants in pwMS compared to healthy controls, considering vaccination hesitancy, MS-specific vaccination beliefs, trust in information sources, and the role of general practitioners (GPs). Methods: This cross-sectional multicenter observational study was conducted in six German MS centers. The primary endpoint was a vaccination index (VI) comprising eight standard vaccinations (range 0–1, with higher VI indicating better vaccination coverage). Secondary endpoints included validated measures of general vaccination hesitancy, MS-specific vaccination beliefs, and trust in information sources. Data were collected through questionnaires, vaccination card analysis, and a survey of GPs who vaccinate pwMS. Results: VI tended to be lower in pwMS ( n = 397) compared to healthy controls ( n = 300; 0.58 ± 0.30 vs 0.62 ± 0.31, p = 0.057). In pwMS receiving highly effective DMTs, VI did not differ significantly from those on no/platform DMTs. Vaccination hesitancy was comparably low, with no differences between pwMS and controls. Vaccination hesitancy, beliefs, and trust in information sources explained only 10%–16% of the variance in VI. Among 109 GPs, 82% cited reluctance to vaccinate pwMS due to concerns about MS-related side effects or interactions with DMTs. Conclusion: Despite clear recommendations from MS societies for full vaccination of all pwMS, vaccination coverage remains worryingly low. Approximately half of the patients lack standard vaccination coverage, even those on highly effective DMTs. In fact, vaccination coverage in pwMS tended to be even lower than in healthy controls. Vaccination hesitancy and other intrinsic factors do not sufficiently explain the low vaccination rates. Inconsistent vaccination recommendations from GPs due to uncertainties about vaccine safety and DMT interactions likely contribute.
Woven EndoBridge 17 device for intracranial aneurysms: A systematic review and meta-analysis
Authors: Rodriguez-Calienes Aaron , Castillo-Huerta Nicole M. , Vivanco-Suarez Juan , Vilca-Salas Martha I. , Bustamante-Paytan Diego , Borjas-Calderón Nagheli Fernanda , Bruno-Peña Anyela Flor , Morán‐Mariños Cristian , Algin Oktay , Guerrero Waldo R. , Ortega-Gutierrez Santiago 
Published: January 2025

Background The Woven EndoBridge 17 (WEB-17) is the latest advancement in the WEB device family. Comprehensive data on its occlusion rates, procedural complications, and mortality is lacking. This meta-analysis aimed to evaluate the efficacy and safety of the WEB-17 device in intracranial aneurysms (IAs). Methods A systematic literature search was conducted from inception to October 2023 across four databases for studies on IAs treated with WEB 17. Primary outcomes included adequate angiographic occlusion at last follow-up and a composite of intraprocedural and postprocedural complications. Comparative meta-analysis between WEB-17 and its predecessor versions (pvWEB) was performed. Subgroup analyses by IA rupture status were also conducted for the primary outcomes. Results Eleven studies with 880 patients and 933 IAs were included. Regarding efficacy, the rate of adequate occlusion at last follow-up was 91% (95% CI 86%–94%) and the complete occlusion rate was 69% (95% CI 65%–73%). Safety outcomes demonstrated a composite complication rate of 7% (95% CI 4%–11%), an intraprocedural complication rate of 7% (95% CI 5%–9%; I2 = 0%), and a postprocedural complication rate of 2% (95% CI 1%–5%; I2 = 0%). No differences were found between WEB-17 and pvWEB in terms of adequate occlusion (WEB-17: 87.7% vs pvWEB: 80.4%; OR = 1.35, 95% CI 0.71-2.55) and safety composite outcome (WEB-17: 8.7% vs pvWEB: 10%; OR = 1.05, 95% CI 0.51-2.16). Subgroup analysis did not evidence heterogeneity between subgroups. Conclusions The WEB-17 device demonstrates promising efficacy and safety profiles for the treatment of IAs. However, these results should be interpreted with caution due to the limited quality of evidence in the included studies. Further prospective, randomized studies are needed to validate these findings.
The Evaluation of Change in Psychosocial Risk With Caregivers of Children With Chronic Kidney Disease: A Short-term Longitudinal Mixed-Methods Study
Authors: Piotrowski Caroline C. , Kudar Kira , Strong Julie , Giesbrecht Ashley , Kazak Anne , Pappas Katerina , Rempel Gina , Goldberg Aviva 
Published: January 2025

Background: The COVID-19 pandemic and its accompanying safeguards intensified many of the ongoing daily challenges faced by caregivers of young people with chronic kidney disease (CKD) both pre-transplant and post-transplant, and also created a variety of new and pressing concerns. Little is known about how these families managed this unexpected adversity in their lives. Objective: To evaluate change in psychosocial risk for families of young people with CKD during the COVID-19 pandemic health emergency from the perspective of caregivers. Design: A short-term longitudinal mixed-methods study with a convergent parallel design. Setting: Manitoba, Canada. Participants: Thirty-six caregivers of young people with CKD participated in a quantitative assessment prior to the pandemic; approximately half were transplant recipients. Thirteen were re-assessed during the pandemic (62% were caregivers of transplant recipients) using both qualitative and quantitative assessments. Methods: First, caregivers completed the Psychosocial Assessment Tool (PAT) prior to the pandemic. Second, caregivers were re-assessed using the PAT during the pandemic. They were also interviewed about their experiences. Changes in PAT scores over time were evaluated, including an investigation of whether psychosocial risk was related to transplant status. Interviews were coded using thematic analysis. In the interpretation stage, the qualitative findings were combined with the quantitative results to help explain the latter and reach a more fulsome understanding of caregivers’ experience. Results: Quantitatively, overall family psychosocial risk scores increased significantly during the pandemic health emergency, as did the domain of Caregiver Problems. Families of transplant recipients were found to be at significantly lower psychosocial risk pre-pandemic than families of transplant candidates. Coding identified Negative Pandemic Experiences, Positive Pandemic Experiences, and Coping Mechanisms. Mixed-methods analyses revealed several areas of convergence and divergence between the quantitative and qualitative findings. Limitations: Limitations included a small sample size that limited generalizability, single site data collection, and single caregiver report. Conclusions: Although overall family psychosocial risk increased during the pandemic, caregivers described several resilience processes and characteristics. A mixed-method approach provided a unique perspective that highlighted the value of integrating quantitative and qualitative findings. Results were discussed within the pediatric psychosocial preventive health model framework.
Digital tool as speech and language therapy for patients with post-stroke aphasia
Authors: Ruiz Ares Gerardo , Martin Alonso Marta , Rigual Ricardo , Hervás Testal Carlos , Torres Iglesias Gabriel , Casado Fernandez Laura , de Celis Ruiz Elena , Rodríguez Pardo Jorge , Carvajal Muñoz Jenny , González Martín Laura , Alonso de Leciñana María , Fuentes Blanca 
Published: January 2025

Introduction New technologies could play a role in post-stroke aphasia (PSA). Our aims were to develop a digital tool; to evaluate its acceptance and usability by patients and caregivers; and to demonstrate its effectiveness in improving language skills in patients with PSA, applying it from the acute phase. Methods The study consisted of two phases: development of a digital tool; and an interventional before-and-after study. During the first week of admission, the digital tool, VerbalizAPP®, was installed for use with the help of family/caregivers. PSA was evaluated by a summarised version of the Boston Diagnostic Aphasia Examination (sBDAE) with 0–64 points. After 3 months of using VerbalizAPP®, the sBDAE and scales to assess user satisfaction were applied. Results Forty patients (29 men, mean age 68.3 years) were included. Aphasia description: Broca's 12 (15.0%), Wernicke's 13 (32.5%), mixed/global 15 (37.5%) cases. Patients began using VerbalizAPP® 4.8 days (range 2–7) after stroke onset. A significant improvement in sBDAE scores was found after 3 months of VerbalizAPP® use: 35.1 (SD 17.6) versus 51.1 (SD 14.4) points; p < .001. Academic level was the only baseline parameter related to outcomes. Comfort of use scored 8.8, and complexity 2.2 points. Expectations were exceeded in 61.1%, and impression of improvement in 83.3% of cases. No adverse effects were reported, and all participants would recommend VerbalizAPP® to other patients. Conclusions Our results show the effectiveness of VerbalizAPP® for the treatment of PSA. However, larger prospective validation studies should be conducted to recommend its widespread use.