bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotropic medication use among adolescents participating in three randomized trials of DBT
Authors: Mehlum Lars , Asarnow Joan , Neupane Sudan Prasad , Santamarina-Perez Pilar , Primé-Tous Mireia , Carlson Gabrielle A. 
Published: February 2024

Abstract
Background
Frequently presenting with symptoms of mood or anxiety disorders, substance abuse or borderline personality disorder, suicidal and self-harming adolescents often are prescribed psychotropic medication. Though such treatment may be warranted, recurrent suicidal and self-harming behaviour is often linked to emotion dysregulation where pharmacological treatment has weak empirical support. There is a need for more clinical research into the frequency, type and rationale for pharmacological treatment in this group. In this secondary analysis of three randomized clinical trials of dialectical behaviour therapy for adolescents, we report on psychotropic medication use in the respective samples at the time of recruitment, compare use of psychotropic medication across trials and describe sample characteristics that may be associated with possible differences in psychotropic medication.

Findings
Trials were conducted in Norway, the US and Spain (labelled the Oslo, US and Barcelona samples). At baseline, 86% of the Barcelona sample, 67% of the US sample and 12% of the Oslo sample were taking at least one psychotropic medication with antidepressants as the most frequent, followed by antipsychotics (72%, 22% and 1.3% respectively) and mood stabilizers (14.2%, 16.2% and 0%). In the Oslo sample there was a significant association between receiving a diagnosis of major depression and the likelihood of receiving antidepressants, but no such association was found in the Barcelona and US samples. The overall 7–8 times higher proportion of participants in the US and Barcelona samples treated with psychotropic medication could only partially be explained by differences between the samples in diagnostic profiles, symptom severity or level of dysfunction.

Conclusions
Highly prevalent in use among suicidal and self-harming adolescents with borderline features, psychotropic medication was still very unevenly prescribed across trials, differences not explained by differences in sample characteristics suggesting that current treatment practices are not fully empirically supported. We call for continued medical education and increased availability of evidence-based psychosocial interventions.
Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi: a scoping review
Authors: Sánchez Pérez Ricardo , Aranda-Coello José Manuel , De Fuentes Vicente José Antonio , Chávez Oscar Rico 
Published: February 2024

AbstractTrypanosoma cruzi is the etiologic agent of Chagas disease. This flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family (known as “kissing bugs”). Despite the fact that hundreds of species of wild mammals are part of the reservoir system, the morphological changes and clinical manifestations resulting from the pathogenesis of the infection have been largely neglected. The aim of this review is to systematically compile the available information regarding clinicopathological alterations in wild mammals due to natural infection by T. cruzi. Information was obtained from six online bibliographic data search platforms, resulting in the identification of 29 publications that met the inclusion criteria. Mortality was the most common clinical manifestation, cardiac damage was the main finding at necropsy, and lymphoplasmacytic inflammation was the most frequent microscopic injury. Thus, regardless of its role as a reservoir, T. cruzi has the potential to affect the health status of wild mammals, a situation that highlights the need for further research to analyze, measure, and compare its effects at both the individual and population levels.
Coronary artery anomalies and the role of echocardiography in pre-participation screening of athletes: a practical guide
Authors: Bhatia Raghav T. , Forster Jan , Ackrill Melanie , Chatrath Nikhil , Finocchiaro Gherardo , Fyyaz Saad , MacLachlan Hamish , Malhotra Aneil , Marwaha Sarandeep , Papadakis Michael , Ring Liam , Sharma Sanjay , Oxborough David , Rakhit Dhrubo 
Published: February 2024

AbstractTransthoracic echocardiography is an essential and widely available diagnostic tool for assessing individuals reporting cardiovascular symptoms, monitoring those with established cardiac conditions and for preparticipation screening of athletes. While its use is well-defined in hospital and clinic settings, echocardiography is increasingly being utilised in the community, including in the rapidly expanding sub-speciality of sports cardiology. There is, however, a knowledge and practical gap in the challenging area of the assessment of coronary artery anomalies, which is an important cause of sudden cardiac death, often in asymptomatic athletic individuals. To address this, we present a step-by-step guide to facilitate the recognition and assessment of anomalous coronary arteries using transthoracic echocardiography at the bedside; whilst recognising the importance of performing dedicated cross-sectional imaging, specifically coronary computed tomography (CTCA) where clinically indicated on a case-by-case basis. This guide is intended to be useful for echocardiographers and physicians in their routine clinical practice whilst recognising that echocardiography remains a highly skill-dependent technique that relies on expertise at the bedside.
Graphical Abstract
Stent-induced new entry and device migration associated with hemodynamic stress after thoracic endovascular aortic repair for type B chronic aortic dissection using computational fluid dynamics analysis: a case report
Authors: Hosaka Itaru , Uzuka Takeshi , Umeta Riko , Sasaki Akihiko 
Published: February 2024

Abstract
Background
Stent graft-induced new entry (SINE) after thoracic endovascular aortic repair (TEVAR) is a serious adverse event which leads to stent graft migration and rupture. SINE is known to be more frequent in cases of chronic dissection and oversizing. However, few studies have evaluated the influence of hemodynamic stress on SINE in patients with chronic dissection. Here, we report a rare case of TEVAR for chronic dissection with a dissection stent, inducing SINE 6 years after the first surgery. In addition, we analyze the hemodynamic stress for the aortic event using computational fluid dynamics (CFD) analysis.

Case presentation
A 69-year-old male underwent TEVAR with left subclavian artery debranching for chronic type B aortic dissection, using a stent graft and dissection stent. The postoperative course was uneventful, but follow-up computed tomography (CT) showed that the stent graft and bare-metal stent had dislodged 4 years after surgery. The gap between the bare-metal stent and the stent graft increased over time, and the proximal edge of the bare-metal stent led to SINE at the descending aorta 6 years after surgery. We performed reintervention to cover the SINE. The patient recovered well and was discharged at 6 days postoperatively. He is currently in good condition 6 months after reintervention. CFD analysis of the patient’s CT image suggested that the local change in wall shear stress at the stent graft and dissection stent might be related to the aortic event.

Conclusion
Hemodynamic stress is a factor affecting SINE and device migration. CFD may be useful for evaluating patient-specific risk of aortic events.
Universality of spectral fluctuations in open quantum chaotic systems
Authors: Jisha C , Prakash Ravi 
Published: February 2024

Abstract
Quantum chaotic systems with one-dimensional spectra follow spectral correlations of Orthogonal (OE), Unitary (UE), or Symplectic Ensembles (SE) of random matrices depending on their invariance under time reversal and rotation. In this letter, we study the non-Hermitian and non-unitary ensembles based on the symmetry of matrix elements, viz. ensemble of complex symmetric, complex asymmetric (Ginibre), and self-dual matrices of complex quaternions. The eigenvalues for these ensembles lie in the two-dimensional plane. We show that the fluctuation statistics of these ensembles are universal and quantum chaotic systems belonging to OE, UE, and SE in the presence of a dissipative environment show similar spectral fluctuations. The short-range correlations are studied using spacing ratio and spacing distribution. For long-range correlations, unfolding at a non-local scale is crucial. We describe a generic method to unfold the two-dimensional spectra with non-uniform density and evaluate correlations using number variance. We find that both short-range and long-range correlations are universal. We verify our results with the quantum kicked top in a dissipative environment that can be tuned to exhibit symmetries of OE, UE, and SE in its conservative limit.
The Value of Biological and Conditional Factors for Staging of Patients with Resectable Pancreatic Cancer Undergoing Upfront Resection: A Nationwide Analysis
Authors: Schouten Thijs J. , van Goor Iris W. J. M. , Dorland Galina A. , Besselink Marc G. , Bonsing Bert A. , Bosscha Koop , Brosens Lodewijk A. A. , Busch Olivier R. , Cirkel Geert A. , van Dam Ronald M. , Festen Sebastiaan , Groot Koerkamp Bas , van der Harst Erwin , de Hingh Ignace H. J. T. , Intven Martijn P. W. , Kazemier Geert , Liem Mike S. L. , van Lienden Krijn P. , Los Maartje , de Meijer Vincent E. , Patijn Gijs A. , Schreinemakers Jennifer M. J. , Stommel Martijn W. J. , van Tienhoven Geert Jan , Verdonk Robert C. , Verkooijen Helena M. , van Santvoort Hjalmar C. , Molenaar I. Quintus , Daamen Lois A. ,   the Dutch Pancreatic Cancer Group
Published: February 2024

Abstract
Background
Novel definitions suggest that resectability status for pancreatic ductal adenocarcinoma (PDAC) should be assessed beyond anatomical criteria, considering both biological and conditional factors. This has, however, yet to be validated on a nationwide scale. This study evaluated the prognostic value of biological and conditional factors for staging of patients with resectable PDAC.

Patients and Methods
A nationwide observational cohort study was performed, including all consecutive patients who underwent upfront resection of National Comprehensive Cancer Network resectable PDAC in the Netherlands (2014–2019) with complete information on preoperative carbohydrate antigen (CA) 19-9 and Eastern Cooperative Oncology Group (ECOG) performance status. PDAC was considered biologically unfavorable (RB+) if CA19-9 ≥ 500 U/mL and favorable (RB−) otherwise. ECOG ≥ 2 was considered conditionally unfavorable (RC+) and favorable otherwise (RC−). Overall survival (OS) was assessed using Kaplan–Meier and Cox-proportional hazard analysis, presented as hazard ratios (HRs) with 95% confidence interval (CI).

Results
Overall, 688 patients were analyzed with a median overall survival (OS) of 20 months (95% CI 19–23). OS was 14 months (95% CI 10 months—median not reached) in 20 RB+C+ patients (3%; HR 1.61, 95% CI 0.86–2.70), 13 months (95% CI 11–15) in 156 RB+C− patients (23%; HR 1.86, 95% CI 1.50–2.31), and 21 months (95% CI 12–41) in 47 RB−C+ patients (7%; HR 1.14, 95% CI 0.80–1.62) compared with 24 months (95% CI 22–27) in 465 patients with RB−C− PDAC (68%; reference).

Conclusions
Survival after upfront resection of anatomically resectable PDAC is worse in patients with CA19-9 ≥ 500 U/mL, while performance status had no impact. This supports consideration of CA19-9 in preoperative staging of resectable PDAC.
Managing recurrent/advanced oropharyngeal/oesophageal cancer with cetuximab-based regimens: A case series
Authors: Dattatreya P. Satya , Nirni Sharabasappa Somnath , Suresh Attilli V 
Published: February 2024

Background: Several clinical trials in a setting of recurrent/metastatic (R/M) squamous cell carcinoma of head and neck (HNSCC) have reported the use of cetuximab with chemotherapy (CT) or radiation therapy (RT). Methods: We report on 14 R/M HNSCC (oropharyngeal/oesophageal cancer). These are the patients who are receiving cetuximab as part of their treatment plan and are on follow-up at time of writing. Results: Seven patients were diagnosed with tongue cancer (#1, #5, #9, #10, #11, #12, and #13) and five patients with cancer of the oral cavity (patient #2, #3, #4, #7 and #14). One patient each had cancer of the oesophagus and larynx, respectively. All patients were treated with CTX (dose: 400 mg–800 mg) for R/M cancer. Patients #1, #3, #4, #5 #7 and #8 received concurrent CT (cisplatin) and RT. Patient #10 received RT and CTX. Patient #8 received docetaxel [doceAqualip], cisplatin, CTX (TPEx) as a second line of therapy after treatment failure with concomitant CT and RT for primary cancer. Patient #11 was switched to nivolumab after stabilizing on TPEx. Patient #13 received docetaxel- cisplatin-5-fluorouracil (5-FU), nivolumab, and afatinib before CTX. Conclusions: Patients had completed a minimum of one and a maximum of six cycles of TPEx. All patients are alive at time of writing.
Feature-Based Inventory Control with Censored Demand
Authors: Ding Jingying , Huh Woonghee Tim , Rong Ying 
Published: February 2024

Problem definition: We study stochastic periodic-review inventory systems with lost sales, where the decision maker has no access to the true demand distribution a priori and can only observe historical sales data (referred to as censored demand) and feature information about the demand. In an inventory system, excess demand is unobservable because of inventory constraints, and sales data alone cannot fully recover the true demand. Meanwhile, feature information about the demand is abundant to assist inventory decisions. We incorporate features for inventory systems with censored demand. Methodology/results: We propose two feature-based inventory algorithms called the feature-based adaptive inventory algorithm and the dynamic shrinkage algorithm. Both algorithms are based on the stochastic gradient descent method. We measure the performance of the proposed algorithms through the average expected regret in finite periods: that is, the difference between the cost of our algorithms and that of a clairvoyant optimal policy with access to information, which is acting optimally. We show that the average expected cost incurred under both algorithms converges to the clairvoyant optimal cost at the rate of [Formula: see text] for the perishable inventory case and [Formula: see text] for the nonperishable inventory case. The feature-based adaptive inventory algorithm results in high volatility in the stochastic gradients, which hampers the initial performance of regret. The dynamic shrinkage algorithm uses a shrinkage parameter to adjust the gradients, which significantly improves the initial performance. Managerial implications: This paper considers feature information. The idea of dynamic shrinkage for the stochastic gradient descent method builds on a fundamental insight known as the bias-variance trade-off. Our research shows the importance of incorporating the bias-variance in a dynamic environment for inventory systems with feature information. Funding: W. T. Huh acknowledges support from the NSERC Discovery Grants [Grant RGPIN 2020-04213] and the Canada Research Chair Program. The work of Y. Rong was supported by the National Natural Science Foundation of China [Grants 72025201, 72331006, and 72221001]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2021.0135 .
Local Elements Content on Working Surfaces of Five Different New Ni-Ti Rotary Endodontic Files: SEM-EDS Study
Authors: Noenko Igor , Fedak Volodymyr , Biley Anastasia 
Published: February 2024

Objective: To assess diversity of local elements content within working surfaces of five different new Ni-Ti rotary endodontic files.
Methods: Energy dispersive spectrometry (EDS) for local elements content analysis was held within three specific areas of working surfaces of the files identified over received SEM images: 1) with pronounced visible signs of impurities; 2) with slightly visible signs of impurities; 3) with no visible signs of impurities. EDS procedure was provided with the use of EDS-detector. Local elements content data at the three above-mentioned specific areas of files’ working surfaces was presented in means of weight percent (wt%), normalized to 100%, and was automatically calculated by the SEM-EDS software.
Results: Expressiveness of visible signs of impurities present over working surfaces of the files demonstrated correlation with nickel (r=-0.62, p < 0.05) and titanium (r=-0.49, p < 0.05) content at analyzed areas, while also with carbon (r=0.57, p < 0.05) and oxygen (r=0.50, p < 0.05) content at analyzed areas. Odds ratio for possibility to register traces of one of the following elements N, Na, Mg, Al, Si, S, Cl, Cr, Fe, Ca at the working surface of endodontic file under condition of present pronounced visible signs of impurities was found to be at the level of OR=12.5 (95% CI: 1.08; 143.44; p=0.04).
Conclusions: None of the analyzed files was free of impurities over their working surface. Carbon, oxygen, nickel, and titanium were the most prevalent elements observed along working surfaces of five new different endodontic files, while some instruments were characterized with the presence of tungsten, silicon, aurum, iron, chromium, magnesium and nitrogen, maximum level of which at selected areas with pronounced visible signs of impurities outreach 10% weight percent values.
Collaboration With Researchers With Intellectual/Developmental Disabilities: An Illustration of Inclusive Research Attributes Across Two Projects
Authors: Kramer Jessica M. , Dean Evan E. , Urquilla Micah Peace , Beasley Joan B. , Linnenkamp Brad 
Published: February 2024

Abstract
Researchers have implemented inclusive research for over 30 years. This article describes how two research projects collaborated with researchers with disabilities and aligns the description with four attributes of inclusive research developed by a consensus of international experts with and without disabilities. The first project, the Person Experiences Interview Survey (PEIS) Workgroup, reviewed and revised items for a self-report survey of mental health service experiences. The second project describes the peer-led implementation of the Self-Determined Career Design Model (SDCDM) intervention. Four factors facilitated or were barriers to the projects’ alignment with inclusive research attributes. First, relationships enhanced capacity to engage in meaningful ways. Second, balance between consistency and adaptability promoted engagement. Third, long-term capacity was enabled by ongoing engagement and peer mentorship. Fourth, time and funds impacted inclusive implementation. Engaging researchers with disabilities meaningfully enhanced the research process and products.
Reconceptualizing Research to Practice: The Role of Self-Advocates in Disrupting How We Think About Implementing Research-Based Practices in Disability
Authors: Broussard Ricky , Gill Norine Jaloway , Dean Evan , Shogren Karrie A. 
Published: February 2024

Abstract
Inclusive research advances the right of people with lived experience with intellectual and developmental disabilities to be involved in all phases of the research process. From an implementation science perspective, a critical component to inclusive research is addressing how research-based practices are adopted, implemented, and sustained in real-world contexts by real-world implementers—who in the context of this special issue are people with lived experience of disability. The purpose of this article is to advance inclusive approaches in the implementation of research-based practices in disability services and supports by highlighting strategies used by an innovative organization that supports self-advocates to implement research-based practices in disability supports and services.
Study on properties of CaF2–CaO–Al2O3–MgO–B2O3 electroslag remelting slag for rack plate steel
Authors: Zhang Yong-jiao , Kong Ling-zhong , Zang Xi-min , Li Shi-sen 
Published: February 2024

Abstract
The loss of boron (B) in the rack plate steel during the electroslag remelting process has a significant impact on its mechanical properties. Therefore, it is necessary to design appropriate slags to suppress the loss of B. CaF2–CaO–Al2O3 phase diagram was calculated to determine the basic slag. The influence of MgO and B2O3 on the performance of the basic slag was studied to determine the optimal amount of MgO addition. The equilibrium reactions between rack plate steel and the 50.48 mass% CaF2–24.81 mass% CaO–24.71 mass% Al2O3–2 mass% MgO-y mass% B2O3 (y was 1–10) slag were studied to examine the variation in B content in the steel. Results indicate the presence of a temperature-qualified eutectic point in the CaF2–CaO–Al2O3 phase diagram. With an increase in MgO content in the slag, the melting temperature of the basic slag initially decreases and then increases, while the electrical conductivity decreases. On the other hand, B2O3 reduces the melting point of the slag and increases the equilibrium B content in the steel. The 50.48 mass% CaF2–24.81 mass% CaO–24.71 mass% Al2O3–2 mass% MgO-y mass% B2O3 (y was 5–7) slag can achieve the target range of B content in the steel, and its viscosity meets the requirements of electric slag remelting.
Regression(s) discontinuity: Using bootstrap aggregation to yield estimates of RD treatment effects
Authors: Long Mark C. , Rooklyn Jordan 
Published: February 2024

Abstract
Following Efron (2014), we propose an algorithm for estimating treatment effects for use by researchers employing a regression-discontinuity (RD) design. This algorithm generates a set of estimates of the treatment effect from bootstrapped samples, wherein the polynomial-selection algorithm developed by Pei, Lee, Card, and Weber (2021) is applied to each sample, the average of these RD treatment effect (RDTE) estimates is computed and serves as the overall estimate of the RDTE. Effectively, this procedure estimates a set of plausible RD estimates and weights the estimates by their likelihood of being the best estimate to form a weighted-average estimate. We discuss why this procedure may lower the estimate’s root mean squared error (RMSE). In simulation results, we show that this better performance is achieved, yielding up to a 5% reduction in RMSE relative to PLCW’s method and a 16% reduction in RMSE relative to Calonico, Cattaneo, and Titiunik’s (2014) method for bandwidth selection (with default settings).
Dirac exciton–polariton condensates in photonic crystal gratings
Authors: Sigurðsson Helgi , Nguyen Hai Chau , Nguyen Hai Son 
Published: February 2024

Abstract
Bound states in the continuum have recently been utilized in photonic crystal gratings to achieve strong coupling and ultralow threshold condensation of exciton–polariton quasiparticles with atypical Dirac-like features in their dispersion relation. Here, we develop the single- and many-body theory of these new effective relativistic polaritonic modes and describe their mean-field condensation dynamics facilitated by the interplay between protection from the radiative continuum and negative-mass optical trapping. Our theory accounts for tunable grating parameters giving full control over the diffractive coupling properties between guided polaritons and the radiative continuum, unexplored for polariton condensates. In particular, we discover stable cyclical condensate solutions mimicking a driven-dissipative analog of the zitterbewegung effect characterized by coherent superposition of ballistic and trapped polariton waves. We clarify important distinctions between the polariton nearfield and farfield explaining recent experiments on the emission characteristics of these long lived nonlinear Dirac polaritons.