bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of symptom-to-reperfusion-time on transmural infarct extent and left ventricular strain in patients with ST-segment elevation myocardial infarction: a 3D view on the wavefront phenomenon
Authors: Demirkiran Ahmet , Beijnink Casper W H , Kloner Robert A , Hopman Luuk H G A , van der Hoeven Nina W , van Pouderoijen Nikki , Janssens Gladys N , Everaars Henk , van Leeuwen Maarten A H , van Rossum Albert C , van Royen Niels , Robbers Lourens F H J , Nijveldt Robin 
Published: October 2023

Abstract

Aims
We examined the association between the symptom-to-reperfusion-time and cardiovascular magnetic resonance (CMR)-derived global strain parameters and transmural infarct extent in ST-segment elevation myocardial infarction (STEMI) patients.

Methods and results
The study included 108 STEMI patients who underwent successful primary percutaneous coronary intervention (PPCI). Patients were categorized according to the median symptom-to-reperfusion-time: shorter (&lt;160 min, n = 54) and longer times (&gt;160 min, n = 54). CMR was performed 2–7 days after PPCI and at 1 month. CMR cine imaging was performed for functional assessment and late gadolinium enhancement to evaluate transmural infarct extent. Myocardial feature-tracking was used for strain analysis. Groups were comparable in relation to incidence of LAD disease and pre- and post-PPCI thrombolysis in myocardial infarction (TIMI) flow grades. The mean transmural extent score at follow-up was lower in patients with shorter reperfusion time (P &lt; 0.01). Both baseline and follow-up maximum transmural extent scores were smaller in patients with shorter reperfusion time (P = 0.03 for both). Patients with shorter reperfusion time had more favourable global left ventricular (LV) circumferential strain (baseline, P = 0.049; follow-up, P = 0.01) and radial strain (baseline, P = 0.047; follow-up, P &lt; 0.01), whilst LV longitudinal strain appeared comparable for both baseline and follow-up (P &gt; 0.05 for both). In multi-variable regression analysis including all three strain directions, baseline LV circumferential strain was independently associated with the mean transmural extent score at follow-up (β=1.89, P &lt; 0.001).

Conclusion
In STEMI patients, time-to-reperfusion was significantly associated with smaller transmural extent of infarction and better LV circumferential and radial strain. Moreover, infarct transmurality and residual LV circumferential strain are closely linked.
The Unlevel Playing Field: Gender, Discrimination, and Global Attitudes toward Trade
Authors: Guisinger Alexandra , Kleinberg Katja B 
Published: October 2023

Abstract
The gender gap in support for trade is one of the most robust empirical findings to emerge from research on public opinion in international political economy. Even controlling for differences in education, skill level, industry affiliation, and other factors, women express consistently more protectionist views than men. Less frequently noted, and thus far unexplained, is that this gender gap varies cross-nationally. We advance an explanation that draws attention to national differences in gender discrimination, predicting that the gender gap will be larger in countries with greater gender discrimination. Using two decades of public opinion data across twenty-two OECD countries and measures of de facto and de jure gender equity, we conduct three separate empirical analyses of the relationship between levels of equity, women’s trade attitudes, and the gender gap. The results support the contention that unequal gender treatment is an important driver of the gender gap in trade attitudes.
Age-Friendly and Climate Resilient Communities: A Grey–Green Alliance
Authors: Dabelko-Schoeny Holly , Dabelko Geoffrey D , Rao Smitha , Damico Melissa , Doherty Fiona C , Traver Anthony C , Sheldon Marisa 
Published: October 2023

Abstract
The world’s population is aging while the Earth’s climate is warming. The climate change crisis poses threats to our aging population and requires concerted action. Steps to address these threats present opportunities for improving livability for people of all ages while addressing the underlying drivers of climate change. Yet prominent action frameworks such as the World Health Organization’s (WHO) Global Network of Age-Friendly Cities and Communities do not explicitly include climate resilience and sustainability as essential elements of age-friendly communities. In this essay, we argue for the creation of a cross-cutting and interdependent sustainability and climate resilience domain to complement the existing interconnected WHO age-friendly domains of community and healthcare, communication and information, housing, civic participation and employment, outdoor spaces and buildings, social participation, respect and social inclusion, and transportation. These domains drive the community engagement, planning, action, and evaluation required by the communities who join the Global Network for Age-Friendly Cities and Communities. The age-friendly network currently includes 1,445 communities, across 51 countries. We discuss how the alignment of age-friendly and climate resilience networks strengthens local action and global advocacy through a shared vision for an age-friendly and climate resilient future.
Genetics of infertility: a paradigm shift for medically assisted reproduction
Authors: Verpoest Willem , Okutman Özlem , Van Der Kelen Annelore , Sermon Karen , Viville Stéphane 
Published: October 2023

Abstract
The field of reproductive genetics has undergone significant advancements with the completion of the Human Genome Project and the development of high-throughput sequencing techniques. This has led to the identification of numerous genes involved in both male and female infertility, revolutionizing the diagnosis and management of infertility patients. Genetic investigations, including karyotyping, specific genetic tests, and high-throughput sequencing, have become essential in determining the genetic causes of infertility. Moreover, the integration of genetics into reproductive medicine has expanded the scope of care to include not only affected individuals or couples but also their family members. Genetic consultations and counselling play a crucial role in identifying potentially affected relatives and offering tailored therapy and the possibility of fertility preservation. Despite the current limited therapeutic options, an increasing understanding of genotype–phenotype correlations in infertility genes holds promise for improved treatment outcomes. The availability of genetic diagnostic tools has reduced the number of idiopathic infertility cases by providing accurate aetiological diagnoses. The transition from research to clinical practice in reproductive genetics requires the establishment of genetic consultations and data warehousing systems to provide up-to-date information on gene–disease relationships. Overall, the integration of genetics into reproductive medicine has brought about a paradigm shift, emphasizing the familial dimension of infertility and offering new possibilities for personalized care and family planning.
Leveraging data from a private recreational fishing application to begin to understand potential impacts from offshore wind development
Authors: DePiper Geret , Corvi Dennis , Steinback Scott , Arrington D Albrey , Blalock Rick , Roman Nate 
Published: October 2023

Abstract
The development of offshore wind energy in the United States necessitates a sound understanding of trade-offs across ocean uses. Location data on private recreational fishing have been a glaring gap in understanding how society uses marine resources, despite its economic importance. In this study, we use a novel data set to start to fill that knowledge gap. We employ a flexible restricted likelihood spatial scan statistic on data from Fish Rules, a smartphone application, which provides georeferenced species-level regulations, to understand whether species-level data of user queries are clustered spatially. Originally developed for epidemiological studies of disease clusters, the flexible scan statistic employed in this study uses a Bernoulli likelihood ratio test to assess the size, number, and significance of clusters in presence/absence data for recreational species. We use a second data set of known fishing locations to validate that the clusters identify private recreational fishing activity. We then discuss the analysis in the context of wind lease areas in the region, highlighting its value in supporting management decision-making. The results suggest that Fish Rules data identify areas with a high likelihood of being private angler fishing locations and can assess differential impacts of offshore wind development on private recreational fishing activities.
Lorentzian Fans
Authors: Ross Dustin 
Published: October 2023

Abstract
We introduce the notion of Lorentzian fans, which form a special class of tropical fans that are particularly well-suited for proving Alexandrov–Fenchel-type inequalities. To demonstrate the utility of Lorentzian fans, we prove a practical characterization of them in terms of their two-dimensional star fans. We also show that Lorentzian fans are closed under many common tropical fan operations, and we discuss how the Lorentzian property descends to the underlying tropical variety, allowing us to deduce Alexandrov–Fenchel-type inequalities in the general setting of tropical intersection theory on tropical fan varieties.
‘Hey Siri, You’re Dumb!’: Investigating Blurting Instances of Voice-Based Assistants
Authors: Rijhwani V , Edwards C 
Published: October 2023

Abstract
Voice-based assistants (VBAs) are transforming how we interact with technology. We rely heavily on VBAs (such as Siri, Alexa and Google Assistant) to manage our daily routines and tasks. The current study extends past research on blurting to the human–machine communication (HMC) context. An online survey (n = 185) was conducted to investigate blurting with a VBA. We analysed open-ended accounts of instances in which participants had blurted during conversations with a VBA. In addition, findings show that blurting with a VBA is related to the less sophisticated views of interpersonal arguments and higher argument seeking, verbal aggressiveness, psychological reactance, extraversion and neuroticism. Our findings suggest that although people blurt with VBAs, in line with the general Computers Are Social Actors paradigm, the reasons are unique to HMC.
Population genetics of Leptoglossus clypealis (Hemiptera: Coreidae) in the Western United States
Authors: Esquivel Jesus F , Joyce Andrea L 
Published: October 2023

Abstract
The leaffooted bug, Leptoglossus clypealis Heidemann, is a seed-feeding economic pest of crops including almonds and pistachios. The historical distribution of L. clypealis has been considered to be West of the Mississippi in the United States. L. clypealis was recently found in sorghum in the Coastal Bend of Texas, representing a new host record and new collection locality. This study investigated the genetic diversity of L. clypealis museum voucher samples from the Western United States (i.e., Texas, California, and Idaho) collected from 1994 to 2019, including the L. clypealis samples from the Coastal Bend. Eleven new sequences were obtained. Sample sequences were compared with public sequences of L. clypealis from the Western United States. The mitochondrial DNA cytochrome oxidase 1 (mtDNA COI) barcode gene region revealed differences among and within the collection regions. Texas, Idaho, and California all had samples with unique genotypes, and the combined dataset had a haplotype diversity of 1.0. The Texas specimens recently collected in the Coastal Bend did not match genotypes from California or Idaho, and it is unlikely they were recently introduced. Overall, L. clypealis from Texas, Idaho, and California have a high level of genetic diversity, and the 3 regions appear to be within the native range of the species.
A phase III randomized controlled trial comparing local field with additional prophylactic irradiation in chemoradiotherapy for clinical-T1bN0M0 esophageal cancer: ARMADILLO trial (JCOG1904)
Authors: Sasaki Keita , Nomura Motoo , Kato Ken , Sakanaka Katsuyuki , Ito Yoshinori , Kadota Tomohiro , Machida Ryunosuke , Kataoka Tomoko , Minashi Keiko , Tsubosa Yasuhiro , Kajiwara Takeshi , Fukuda Haruhiko , Takeuchi Hiroya , Mizowaki Takashi , Nishimura Yasumasa , Kitagawa Yuko 
Published: October 2023

Abstract
Chemoradiotherapy has been considered as one of the standard treatment options for clinical T1bN0M0 esophageal squamous cell carcinoma with organ preservation. However, 20% of patients develop locoregional recurrence after chemoradiotherapy, which requires salvage treatment including salvage surgery and endoscopic resection. Salvage surgery can cause complications and treatment-related death. Interestingly, chemoradiotherapy with elective nodal irradiation has been reported to reduce the locoregional recurrence of advanced esophageal squamous cell carcinoma. Hence, we are conducting a clinical trial to confirm whether modified chemoradiotherapy with elective nodal irradiation was superiority to that without elective nodal irradiation for the patients with cT1bN0M0 esophageal squamous cell carcinoma. The primary endpoint is major progression-free survival, defined as the time from randomization to the date of death or disease progression, excluding successful curative resection through salvage endoscopic resection. We plan to enroll 280 patients from 54 institutions over 4 years. This trial has been registered in the Japan Registry of Clinical Trials (jRCTs031200067).
Are Zhuzi contentious? A rhetorical investigation of speech/word radicals in ancient Chinese texts
Authors: Liu Jiao , Li Ke 
Published: October 2023

AbstractIn communication, rhetors are inclined to employ contentious rhetorical modes designed to win or compete. Consequently, noncontentious rhetorical modes, such as invitational rhetoric, are underappreciated. This study fosters a better understanding of the rationale and possibility of noncontentious rhetorical modes rooted in texts by traditional Chinese intellectuals. We identify, classify, and interpret indigenous terms identified with speech/word radicals in nine Chinese philosophical classics across five major schools of thought in ancient China using a corpus-driven approach and key concepts of rhetorical studies to delineate the pattern, components, and modes of ancient Chinese rhetoric. The results show that (1) characters with speech/word radicals in ancient Chinese texts follow a pattern between rank and frequency; (2) basic components of rhetorical acts in ancient China can be described based on these terms, and characteristic rhetorical components are identified upon similarities and differences among five schools of thought; and (3) studying rhetorical modes of ancient Chinese rhetoric with speech/word radicals reveals that intellectuals in ancient China adopted both the contentious modes and the noncontentious modes of rhetoric. This study also demonstrates the possibility of studying semantic radicals in texts through digital methods to delineate ancient Chinese rhetoric.
Horizontally Transferred Salivary Protein Promotes Insect Feeding by Suppressing Ferredoxin-Mediated Plant Defenses
Authors: Wang Yi-Zhe , Ye Yu-Xuan , Lu Jia-Bao , Wang Xin , Lu Hai-Bin , Zhang Ze-Long , Ye Zhuang-Xin , Lu Yu-Wen , Sun Zong-Tao , Chen Jian-Ping , Li Jun-Min , Zhang Chuan-Xi , Huang Hai-Jian 
Published: October 2023

Abstract
Herbivorous insects such as whiteflies, planthoppers, and aphids secrete abundant orphan proteins to facilitate feeding. Yet, how these genes are recruited and evolve to mediate plant–insect interaction remains unknown. In this study, we report a horizontal gene transfer (HGT) event from fungi to an ancestor of Aleyrodidae insects approximately 42 to 190 million years ago. BtFTSP1 is a salivary protein that is secreted into host plants during Bemisia tabaci feeding. It targets a defensive ferredoxin 1 in Nicotiana tabacum (NtFD1) and disrupts the NtFD1–NtFD1 interaction in plant cytosol, leading to the degradation of NtFD1 in a ubiquitin-dependent manner. Silencing BtFTSP1 has negative effects on B. tabaci feeding while overexpressing BtFTSP1 in N. tabacum benefits insects and rescues the adverse effect caused by NtFD1 overexpression. The association between BtFTSP1 and NtFD1 is newly evolved after HGT, with the homologous FTSP in its fungal donor failing to interact and destabilize NtFD1. Our study illustrates the important roles of horizontally transferred genes in plant–insect interactions and suggests the potential origin of orphan salivary genes.
Optimal dose of intravenous cyclophosphamide during remission induction therapy in ANCA-associated vasculitis: A retrospective cohort study of J-CANVAS
Authors: Sofue Hideaki , Kida Takashi , Hirano Aiko , Omura Satoshi , Kadoya Masatoshi , Nakagomi Daiki , Abe Yoshiyuki , Takizawa Naoho , Nomura Atsushi , Kukida Yuji , Kondo Naoya , Yamano Yasuhiko , Yanagida Takuya , Endo Koji , Hirata Shintaro , Matsui Kiyoshi , Takeuchi Tohru , Ichinose Kunihiro , Kato Masaru , Yanai Ryo , Matsuo Yusuke , Shimojima Yasuhiro , Nishioka Ryo , Okazaki Ryota , Takata Tomoaki , Ito Takafumi , Moriyama Mayuko , Takatani Ayuko , Miyawaki Yoshia , Ito-Ihara Toshiko , Yajima Nobuyuki , Kawaguchi Takashi , Fujioka Kazuki , Fujii Wataru , Seno Takahiro , Wada Makoto , Kohno Masataka , Kawahito Yutaka 
Published: October 2023

ABSTRACT

Objectives
To identify the optimal dose of intravenous cyclophosphamide (IVCY) for induction therapy for anti-neutrophil cytoplasmic antibody-associated vasculitis.

Methods
We retrospectively assessed patients with antibody-associated vasculitis who received IVCY every 2–3 weeks during the remission induction phase. The associations of the IVCY dose with infection-free survival and relapse-free survival were analysed using a Cox regression model. We compared patients in three categories: very low-dose (VLD), low-dose (LD), and conventional dose (CD) (&lt;7.5 mg/kg, 7.5–12.5 mg/kg, and &gt;12.5 mg/kg, respectively). The non-linear association between IVCY dose and the outcomes was also evaluated.

Results
Of the 80 patients (median age 72 years), 12, 42, and 26 underwent the VLD, LD, and CD regimens, respectively, of whom 4, 3, and 7 developed infection or died. The adjusted hazard ratios for infection or death were 4.3 (95% confidence interval (CI) 0.94–19.8) for VLD and 5.1 (95% CI 1.21–21.3) for CD, compared with LD. We found the hazard ratio for infection or death increased when the initial IVCY dose exceeded 9 mg/kg. Relapse-free survival did not differ clearly.

Conclusion
Low-dose IVCY (7.5–12.5 mg/kg) may result in fewer infections and similar relapse rates compared with the conventional regimen (&gt;12.5 mg/kg).
Empirical Antibiotic Therapy in Diabetic Foot Ulcer Infection Increases Hospitalization
Authors: Schmidt Brian M , Kaye Keith S , Armstrong David G , Pop-Busui Rodica 
Published: October 2023

Abstract

Background
We evaluated the outcomes associated with initial antibiotic management strategies for infected diabetic foot ulcers (DFUs) diagnosed in an outpatient multidisciplinary center.

Methods
Consecutive outpatient individuals with infected DFUs, stratified according to Infectious Diseases Society of America infection severity, were followed for 1 year from the initial antibiotic administration to treat acute infection. The main outcomes were hospitalization rates for a diabetes-related foot complication within 30 days of diagnosis and requiring an amputation or death during follow-up. Outcomes were analyzed by regression analysis, accounting for demographics, clinical characteristics, and antibiotic therapy.

Results
Among 147 outpatients with infected DFUs, 116 were included. Infections were categorized as mild (68%), moderate (26%), and severe (6%). Empirical antibiotics (not culture-guided) were prescribed as initial treatment in 39 individuals, while 77 received culture-based antibiotics. There were no differences in demographic or clinical characteristics between the antibiotic administration groups, except for a higher body mass index and prevalence of chronic kidney disease in the empirical cohort. Forty-two infected DFU patients required hospitalization within 30 days of diagnosis for the same reason. The relative risk for hospitalizations was 1.87 greater in those with mild infections when treated with empirical antibiotics compared with culture-directed antibiotics. There were no differences in amputations and/or death at 1 year follow-up.

Conclusions
These data support obtaining tissue culture to guide antibiotic therapy, regardless of DFU infection severity, to decrease hospitalizations.
Hospital admissions and emergency department visits for people with dementia
Authors: Zafeiridi E , McMichael A , O’Hara L , Passmore P , McGuinness B 
Published: October 2023

Summary

Background
Previous studies have suggested that people with dementia (PwD) are more likely to be admitted to hospital, have prolonged hospital stay, or visit an emergency department (ED), compared to people without dementia.

Aim
This study assessed the rates of hospital admissions and ED visits in PwD and investigated the causes and factors predicting this healthcare use. Further, this study assessed survival following hospital admissions and ED visits.

Design
This was a retrospective study with data from 26 875 PwD and 23 961 controls.

Methods
Data from national datasets were extracted for demographic characteristics, transitions to care homes, hospital and ED use and were linked through the Honest Broker Service. PwD were identified through dementia medication and through causes for hospital admissions and death.

Results
Dementia was associated with increased risk of hospital admissions and ED visits, and with lower odds of hospital readmission. Significant predictors for hospital admissions and readmissions in PwD were transitioning to a care home, living in urban areas and being widowed, while female gender and living in less deprived areas reduced the odds of admissions. Older age and living in less deprived areas were associated with lower odds of an ED visit for PwD. In contrast to predictions, mortality rates were lower for PwD following a hospital admission or ED visit.

Conclusions
These findings result in a better understanding of hospital and ED use for PwD. Surprisingly, survival for PwD was prolonged following hospital admissions and ED visits and thus, policies and services enabling these visits are necessary, especially for people who live alone or in rural areas; however, increased primary care and other methods, such as eHealth, could provide equally effective care in order to avoid distress and costs for hospital admissions and ED visits.