bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oligomerized Electron Acceptors with Alkynyl Linkages to Suppress Electron‐Photon Coupling for Low‐Energy‐Loss Organic Solar Cells
Authors: Yang Fan , Fang Haisheng , Guo Erqin , Xiao Chengyi , Lu Ziheng , Wang Yuwen , Fan Haiyun , Zhang Andong , Lai Wenbin , Li Weiwei 
Published: January 2025

AbstractA novel series of alkynyl‐linked oligomerized electron acceptors have been synthesized via Sonogashira coupling. The alkynyl linkages can enhance molecular planarity and aggregation, suppress electron‐phonon coupling, and reduce non‐radiative losses. Binary organic solar cells (OSCs) achieved an efficiency of 17.90%, with a non‐radiative loss of 0.185 eV, while ternary OSCs reached a remarkable efficiency of 19.52%. Oligomerized electron acceptors, featuring molecular weights akin to polymers and well‐defined chemical structures, have emerged as promising candidates for organic solar cells (OSCs) due to their consistent batch‐to‐batch reproducibility and improved thermal stability. In this study, we developed a series of oligomerized electron acceptors incorporating alkynyl linkages via an efficient Sonogashira coupling reaction between alkyne‐substituted Y‐type precursors and multi‐substituted iodobenzenes. This method produced monomeric (S‐Alkyne‐YF), dimeric (D‐Alkyne‐YF), and trimeric (T‐Alkyne‐YF) configurations, enabling systematic control over molecular size and substituent arms. The alkynyl linkages, characterized by high bond strength and planar geometry, enhanced molecular planarity and aggregation in films, thus facilitating precise control over morphology and phase separation in the photoactive layers. Notably, the inclusion of these linkages effectively suppressed electron‐phonon coupling, resulting in reduced non‐radiative energy losses and elevated photocarrier lifetime. OSCs based on PM6:T‐Alkyne‐YF achieved a power conversion efficiency of 17.90%, a low non‐radiative energy loss of 0.185 eV, and an open‐circuit voltage of 0.943 V. Furthermore, integrating T‐Alkyne‐YF into the D18:N3 blend yielded an exceptional PCE of 19.52%. These results underscore the potential of alkynyl‐linked oligomerized acceptors in advancing highly efficient and stable OSCs, offering a viable pathway for reducing electron‐phonon coupling and enhancing device performance.
Preparation and Properties of Reprocessable Phenolic Resin Based on Modification of Long‐Chain Isocyanate
Authors: Ya'nan Wang , Fengxiang Cao , Wentao Ren , Kunyao Wu , Qiufeng Wang , Zhao Li 
Published: January 2025

ABSTRACTPhenolic resin has high heat resistance and excellent mechanical properties, and its cross‐linked network structure shows excellent mechanical properties after curing. However, it is difficult to recycle the cross‐linked phenolic resin because of its insoluble and infusible features. In order to make the phenolic resin recyclable and reprocessable, we introduced polymethylene polyphenyl polyisocyanate (PAPI) into the phenolic resin, made the phenol hydroxyl group react with the isocyanate group to form reversible dynamic covalent bond, and prepared the modified phenolic resin (PANR). The structure, thermal stability, mechanical properties, fracture morphology and reprocessable of PANR were characterized. The results showed that when PAPI was introduced into NR, the successfully cross‐linked to form dynamic covalent bonds. DSC showed that the glass transition temperature of PANR was as high as 175°C, and TGA showed that the mass retention rate of PANR was still about 40% at 800°C. The tensile strength of PANR is 14.7 MPa, and its tensile strength and chemical properties remain more than 95% of the original mechanical properties after five cycles, which successfully realizes the recovery and reprocessing of cured phenolic resin. PANR is expected to be used in the reprocessing of phenolic resin.
Impact of a Nurse Navigator Program on Referral Rates and Use of Fertility Preservation Among Female Cancer Patients: A 14‐Year Retrospective Cohort Study
Authors: Naert Mackenzie , Sorouri Kimia , Lanes Andrea , Kempf Abigail M. , Chen Lucy , Goldman Randi , Partridge Ann H. , Ginsburg Elizabeth , Srouji Serene S. , Walker Zachary 
Published: January 2025

ABSTRACTIntroductionGiven the known detrimental impact of cancer treatment on fertility, fertility preservation (FP) is recommended for reproductive age patients who are newly diagnosed with cancer. However, the rate of referral to fertility specialists remains suboptimal. The objective of this study was to determine the impact of a dedicated Nurse Navigator Program (NNP) on the rate of referrals and utilization of FP services.MethodsA retrospective cohort study of all women ≥ 18 years old referred for FP consultation with a known cancer diagnosis from 2007 to 2021 at a single, large academic center was conducted. FP referrals for non‐cancer indications were excluded. Descriptive statistics were performed including comparing referrals received per 30 days and FP utilization rates pre‐NNP (October 2007–September 2013) to post‐NNP (October 2013–December 2021).ResultsA total of 176 patients were included pre‐NNP and 990 patients post‐NNP. Overall, the mean age at the time of referral was 31.5 ± 6.9 years. The referral rates post‐NNP were higher among those without prior exposure to chemotherapy/radiation (0.33 pre‐NNP vs. 2.75 post‐NNP per 30 days, p < 0.01) and lower among those with prior exposure to chemotherapy/radiation (1.26 pre‐NNP vs. 0.70 post‐NNP per 30 days, p < 0.01).ConclusionsAfter the launch of a dedicated fertility preservation nurse navigation program at our institution, we observed a higher number of referrals for FP as well as greater use of FP overall. While not the only variable that changed during this period, this program has optimized patient care and clinical workflow at our institution and serves as a model for such improvement.
A Water‐Stable Hydrogen‐Bonded Organic Framework (HOF) for Selective Sensing of Antibiotics in Aqueous Medium
Authors: Sahoo Rupam , Mariya Tedy Annette , Manna Arun K. , Das Madhab C. 
Published: January 2025

AbstractAlthough metal organic frameworks (MOFs) and covalent organic frameworks (COFs) have been extensively used as fluorescent‐based antibiotic sensors, newly developed hydrogen‐bonded organic frameworks (HOFs) are largely unexplored toward this direction. To realize this, the luminescent HOFs must be stable in water as the analytes are mostly found in water‐based effluents in environments. In addition, HOFs should be equipped with specific recognition sites in order to direct the discrimination among the antibiotics. Herein, we report a 3D porous HOF, IITKGP‐HOF‐6, constructed from an aromatic‐rich tetratopic carboxylic acid (H4L), which exhibits excellent hydro and prolonged open‐air stability (7 and 15 days, respectively). IITKGP‐HOF‐6 was explored for the highly selective detection of nitrofurans (NFs) family of antibiotics in aqueous medium exhibiting a remarkably low detection limit of 0.75 μM for nitrofurazone (NFZ) through luminescence quenching. Photoinduced electron transfer driven by the presence of low‐lying charge‐transfer excited state below to the
and Forster energy transfer between H4L donor and NFZ acceptor are confirmed to be responsible for observed quenching using detailed quantum‐chemical studies. This work demonstrates the usage of HOFs as sensory materials toward antibiotics in aqueous medium along with a clear understanding into the sensing mechanism at the molecular level.
Focus on the Holdrinet index: Toward blast quantification by flow cytometry
Authors: Bonneville Edouard , Jacob Marie‐Christine , Chevalier Simon , Pernollet Martine , Dumestre‐Perard Chantal , Clavarino Giovanna 
Published: January 2025

AbstractBlast quantification in the bone marrow (BM) is crucial for evaluating myeloid neoplasms, with cytomorphology being the only recognized analysis. The CD34 myeloid cell (CD34M) count by flow cytometry is promising but impaired by BM hemodilution. A modified version of the Holdrinet index (mHI) is routinely used to assess it, though not yet validated. By analyzing two differently hemodiluted BM samples from 51 patients with suspicion of myelodysplasia, this study confirms mHI accuracy in assessing BM white blood cell purity. mHI‐adjusted count by flow cytometry of BM‐exclusive cell subsets, such as CD34 myeloid cells, may offer a reliable and practical alternative to cytomorphology analysis, independently from hemodilution.
Efficacy of Percutaneous Suture Suspension Biomaterials in Brow Lift: A Systematic Review
Authors: Shah Rashesh , Kumar Vaibhav , Shome Debraj , Kapoor Rinky , Tandel Harshal 
Published: January 2025

ABSTRACTBackgroundAging is a global biological process characterized by degenerative changes in physiological systems, most notably a decrease in face muscle tone and soft tissue volume, which have a substantial impact on facial esthetics in the periorbital area. This systematic study assesses the clinical outcomes of different thread lifting procedures for brow rejuvenation, with an emphasis on safety, efficacy, and side effects.MethodsTo promote scientific rigor and transparency, this systematic review used the latest PRISMA‐E guidelines (2020). A thorough literature search was carried out using numerous databases, including Google Scholar, PubMed/MEDLINE, Embase, PsycINFO, TRIP, and the Cochrane Library. The I2 value of 0.92 indicates significant variety in study designs, patient characteristics, and therapies.ResultsA total of 6 studies were included, with 419 patients in sample sizes ranging from 12 to 193 (mean = 69). Participants had an average age of 55 years (range: 21–89) and were monitored for 10–11 months. All investigations used standardized photographic assessments (100%). Ecchymosis and post‐procedural edema were the most common side effects observed, accounting for 83.4% of all cases. Notably, two‐thirds of the studies (66.7%) demonstrated a low risk of bias, indicating moderate methodological robustness and internal validity.ConclusionThread lifting procedures for brow rejuvenation have a positive safety and efficacy profile, providing a viable nonsurgical alternative to established approaches. Future research, particularly large‐scale, long‐term randomized controlled trials, is critical for refining these strategies and developing evidence‐based clinical recommendations.
The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function
Authors: Sullivan Alexander E. , Courvan Meaghan C. S. , Aday Aaron W. , Wasserman David H. , Niswender Kevin D. , Shardelow Emily M. , Wells Emily K. , Wells Quinn S. , Freiberg Matthew S. , Beckman Joshua A. 
Published: January 2025

ABSTRACTBackgroundElevated serum free fatty acid (FFA) concentration is associated with insulin resistance and is a hallmark of metabolic syndrome. A pathological feature of insulin resistance is impaired endothelial function.ObjectiveTo investigate the effect of FFA reduction with either acipimox, a nicotinic acid derivative that impairs lipolysis, or salsalate, a salicylate that reduces basal and inflammation‐induced lipolysis, on insulin‐mediated endothelium‐dependent vasodilation.MethodsThis was a post hoc, combined analysis of two randomised, double‐blind, placebo‐controlled crossover trials. Sixteen subjects were recruited (6 with metabolic syndrome and 10 controls) and randomised to acipimox 250 mg orally every 6 h for 7 days or placebo. Nineteen subjects were recruited (13 with metabolic syndrome and 6 controls) and randomised to receive salsalate 4.5 g/day for 4 weeks or placebo. The primary outcome was the association between FFA concentration and insulin‐mediated vasodilation, measured by venous‐occlusion strain‐gauge plethysmography at baseline and following FFA modulation with the study drugs.ResultsAt baseline, FFA concentration (R = −0.35, p = 0.043) and insulin sensitivity (HOMA‐IR: R = −0.42, p = 0.016, Adipo‐IR: R = −0.39, p = 0.025) predicted insulin‐mediated vasodilation. FFA levels were significantly reduced after drug pretreatment (0.604 vs. 0.491 mmol/L, p = 0.036) while insulin levels, insulin sensitivity and inflammatory markers were unchanged. Despite a reduction in circulating FFA with drug therapy, neither insulin‐stimulated vasodilation nor insulin sensitivity improved.ConclusionsShort‐term reduction of FFA concentration does not improve insulin‐stimulated vasodilation in patients with metabolic syndrome.Trial RegistrationClinicalTrials.gov identifier: NCT00759291 and NCT00760019 (formerly NCT00762827)
Number of Readmissions and Its Determinants Among Patients With Heart Failure at Referral Hospitals in Amhara Region, Northwest Ethiopia: A Cross‐Sectional Study Using Zero‐Inflated Negative Binomial Model, 2023
Authors: Gedfew Mihretie , Tesfaye Bekele , Amha Haile , Wondie Tirusew , Gedif Getnet , Gietaneh Wodajie , Akalu Tadesse Yirga , Yismaw Lieltework , Diress Gedefaw 
Published: January 2025

ABSTRACTBackgroundHeart failure is a leading cause of hospital readmissions in the Amhara region, Northwest Ethiopia.AimThis study aimed to determine the number of readmissions and identify the determinants among patients with heart failure at referral hospitals in the Amhara region, Northwest Ethiopia, in 2023.MethodsA cross‐sectional study was conducted with 663 heart failure patients in Amhara region referral hospitals from September 2022 to February 2023. Simple random sampling was used for patient selection, and data were collected through chart reviews and interviewer‐administered questionnaires. Zero‐inflated negative binomial models were applied for data analysis. Data collection tools were pre‐tested for reliability and validity.ResultsAmong 663 patients, 237 (35.7%) were readmitted at least once. An increased respiratory rate (IRR = 1.015; 95% CI: 1.0004, 1.031; p < 0.044) and longer medication duration (IRR = 1.011; 95% CI: 1.016, 1.051; p < 0.0001) were associated with more readmissions. Patients with poor social support had 59.4% fewer readmissions compared to those with good social support (IRR = −1.595; 95% CI: −0.02, −0.005; p < 0.041). A higher body mass index (IRR = 0.115; 95% CI: 0.035, 0.196; p < 0.004) was linked with a higher likelihood of remaining in the “always‐zero” group, while an increased pulse rate reduced the odds (IRR = −0.013; 95% CI: −0.025, −0.008; p < 0.036). The mortality rate among readmitted patients was 11.39%.ConclusionThis study found significant readmission rates among HF patients. Factors such as respiratory rate and medication duration were linked to increased readmissions, while poor social support was associated with fewer readmissions, this likely reflects limited healthcare access in low‐ and middle‐income countries among individuals with lower social support. The high mortality rate underscores the need for targeted interventions to improve patient outcomes.
Enhancer‐dependent gene regulation in space, time, and malignancies
Authors: Blum Belinda , Dachtler Victoria , Feldmann Angelika 
Published: January 2025

AbstractControl of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells. In this review, we provide an overview of our current understanding of enhancer‐driven gene regulation and discuss how this activity may be integrated across time, followed by epigenetic and structural alterations of enhancers in cancers.
Digital Transformation Disclosure and Bank Loans: An Information Heterogeneity Perspective
Authors: Liu Jianmei , Chen Shujing , Su Fei , Liu Jia 
Published: January 2025

ABSTRACTThis study examines the impact of digital transformation disclosure on firms' ability to obtain bank loans, drawing upon a large dataset of Chinese listed firms from 2007 to 2021. Our findings reveal that both substantive and non‐substantive digital transformation disclosures are positively related to bank loans. However, for firms with higher information credibility, the positive relationship between substantive (non‐substantive) digital transformation disclosures and bank loans is relatively stronger. Channel analyses indicate that digital transformation disclosures bolster the accessibility of bank loans by boosting market attention and mitigating banks' default risk concerns. Moreover, government intervention is an alternative mechanism that impacts corporate access to bank loans. Further analysis reveals that substantive digital transformation disclosures can enhance corporate performance, improve resource allocation efficiency and alleviate underinvestment. In contrast, non‐substantial digital transformation disclosures have no such positive effects and may even lead to overinvestment. The moderating analysis indicates that firms that disclose non‐substantive digital transformation information may obtain excessive bank loans; however, corporate governance quality and FinTech development can constrain such speculative behaviour. Therefore, this study adds to the literature on the impact of digital transformation disclosure and complements studies on the determinants of bank loans.
International multistakeholder consensus statement on post‐publication integrity issues in randomized clinical trials by Cairo Consensus Group
Authors: Khan Khalid Saeed , Fawzy Mohamed , Chien Patrick , Geary Michael , Bueno‐Cavanillas Aurora , Nunez‐Nunez Maria , Zamora Javier , Bedaiwy Mohamed , Serour Gamal , D'Hooghe Thomas , Pacey Allan , Andrews Jeff , Scott James R. , Ball Elizabeth , Mahran Ali , Aboulghar Mohamed , Wasim Tayyiba , Abdelaleem Mahmoud , Maheshwari Abha , Odibo Anthony , Sallam Hassan , Grandi Giovanni , Zhang Jim , Fernández‐Luna Juan Manuel , Jawid Shaukat Ali , Mignini Luciano E. , Khalaf Yacoub 
Published: January 2025

AbstractThe number of retractions of randomized clinical trials (RCTs) following post‐publication allegations of misconduct is increasing. To address this issue, we aimed to establish an international multistakeholder consensus on post‐publication integrity concerns related to RCTs. After prospective registration (https://osf.io/njksm), we assembled a multidisciplinary stakeholder group comprising 48 participants from 18 countries across six continents, recruited using a curated list of journal editors and snowballing. An underpinning evidence synthesis collated 89 articles related to post‐publication integrity concerns. Integrity statements related to RCTs created were subjected to anonymized two‐round Delphi survey. A hybrid face‐to‐face‐online consensus development meeting was convened to consolidate the consensus. The response rates of the two Delphi survey rounds were 65% (31/48) and 67% (32/ 48), respectively. There were 101 and 41 statements in the first and second Delphi rounds, respectively. After the two Delphi rounds and the consensus development meeting, consensus was achieved on 104 statements consolidated to 84 after merging, editing, and removing duplicates. This set of statements included general aspects (n = 9), journal instructions (n = 14), editorial and peer review (n = 7), correspondence and complaints (n = 4), investigations for integrity concerns (n = 16), decisions and sanctions (n = 9), critical appraisal guidance (n = 1), systematic reviews of RCTs (n = 8), and research recommendations (n = 16). In conclusion, this international multistakeholder consensus statement aimed to underpin policies for preventing post‐publication integrity concerns in RCT publications and assist in improving investigations of misconduct allegations.
Pharmacokinetics, safety and efficacy of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in children with HIV aged from 2 years and weighing at least 14 kg
Authors: Natukunda Eva , Gaur Aditya H. , Kosalaraksa Pope , Hellström Elizabeth , Strehlau Renate , Liberty Afaaf , Cox Stephanie , Leisegang Rory , Palaparthy Ramesh , Crowe Susanne , Vieira Vinicius , Kersey Kathryn , Rakhmanina Natella 
Published: January 2025

AbstractIntroductionElvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) was efficacious and well tolerated in children/adolescents with HIV (aged ≥6 years, weighing ≥25 kg) in a Phase 2/3 study. Here, we report data from children aged ≥2 years and weighing ≥14–<25 kg.MethodsThis is an analysis of data from the youngest cohort in an open‐label, multicentre, multi‐cohort, single‐group, international study of children/adolescents with HIV. Participants in this cohort were children aged ≥2 years, weighing ≥14–<25 kg at screening and able to swallow tablets, on stable antiretroviral therapy with virologic suppression (HIV‐1 RNA <50 copies/ml for ≥6 consecutive months) and a CD4 count ≥400 cells/µl. Eligible participants received low‐dose E/C/F/TAF (90/90/120/6 mg) once daily through Week 48. The study included pharmacokinetic evaluation of the low‐dose E/C/F/TAF tablet at Week 2. Safety, efficacy, palatability and acceptability were also evaluated.ResultsBetween 16 January and 25 November 2019, 27 participants were enrolled with a median (quartile [Q]1, Q3) age of 6 (4, 8) years, body weight of 19.3 (17.0, 20.5) kg, CD4 count of 1061 (895, 1315) cells/µl and CD4 cell percentage of 37.4 (30.6, 40.3). Most (92.6%) participants acquired HIV through vertical transmission. On 6 October 2020 (data‐cut), median (Q1, Q3) exposure to E/C/F/TAF was 48.3 (48.0, 60.1) weeks. Pharmacokinetic parameters were within the safe and efficacious range of previous data in adult and paediatric populations. Drug‐related treatment‐emergent adverse events occurred in 4/27 (15%) participants. There were no Grade 3/4 adverse events, or adverse events leading to E/C/F/TAF discontinuation. One participant experienced a serious treatment‐emergent adverse event (Grade 2 pneumonia not considered E/C/F/TAF related). Virologic suppression (US FDA Snapshot algorithm) was maintained by 26/27 (96%) participants at Weeks 24 and 48. At Week 48, most children reported positive palatability (84.6%) and acceptability (96.2%).ConclusionsThese data support the use of single‐tablet E/C/F/TAF (90/90/120/6 mg) regimen for the treatment of HIV in children aged ≥2 years and weighing ≥14–<25 kg.Clinical Trial NumberNCT01854775
Is Soil Fertility the Cause or the Effect of Land Invasion by Prosopis?
Authors: Becker Mathias , Behn Kai , Heller Gereon , Kamiri Hellen W. 
Published: January 2025

ABSTRACTBackgroundFor 20 years, Prosopis juliflora is aggressively spreading throughout the “Njemps Flats” in Kenya, where it changes vegetation cover and affects pastoral livelihoods. Its invasion dynamics is related to shallow groundwater tables (Prosopis being a phreatophyte), and it reportedly preferentially colonizes sites with favourable soil fertility attributes.AimWe contest this latter hypothesis, surmising that the N2‐fixing ability, the nutrient pumping by the deep root system, and year‐round leaf litter fall will improve soil fertility attributes under Prosopis, irrespective of the initial soil status.MethodsWe assessed stand densities (number of individuals and their percentage cover) and selected soil attributes at 75 sites in the Njemps Flats. The stand densities of Prosopis were visualized by ground‐truthed remote‐sensed data, and subsequently related to soil fertility attributes. We further determined the isotope signatures (δ15N and δ13C) of the prevailing (past) C4‐dominated pasture and the (current) C3‐Prosopis vegetation, as well as at three depths of the topsoil.ResultsThe findings confirm favourable fertility attributes (low EC and high N, C, P, and K contents) being associated with dense Prosopis stands. However, the isotope analysis of the topsoil indicates typical signatures of C4 vegetation in non‐invaded pastureland and typical signatures of N2‐fixing C3‐plants in the top 5 cm (but not at deeper layers) of soils in Prosopis stands. Prosopis contributes about 16% of N derived from fixation, and significantly increases C, N, P, and Ca contents of the topsoil.ConclusionsWe conclude that high soil fertility is the result rather than the driver of Prosopis invasion.