bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning approaches for adequate prediction of flow resistance in alluvial channels with bedforms
Authors: Mir Ajaz Ahmad , Patel Mahesh 
Published: December 2023

Abstract
In natural rivers, flow conditions are mainly dependent on flow resistance and type of roughness. The interactions among flow and bedforms are complex in nature as bedform dynamics primarily regulate the flow resistance. Manning's equation is the most frequently used equation for this purpose. Therefore, there is a need to develop alternate reliable techniques for adequate prediction of Manning's roughness coefficient (n) in alluvial channels with bedforms. Thus, the main objective of this study is to utilize machine learning (ML) models for predicting ‘n’ based on the six input features. The performance of ML models was assessed using Pearson's coefficient (R2), sensitivity analysis, Taylor's diagram, box plots, and K-fold method has been used for the cross-validation. Based on the output of the current work, models such as random forest, extra trees regression, and extreme gradient boosting performed extremely well (R2 ≥ 0.99), whereas, Lasso Regression models showed moderate efficiency in predicting roughness. The sensitivity analysis indicated that the energy grade line has a significant impact in predicting the roughness as compared to the other parameters. The alternate approach utilized in the present study provides insights into riverbed characteristics, enhancing the understanding of the complex relationship between roughness and other independent parameters.
Seasonality of nitrous oxide emissions at six full-scale wastewater treatment plants
Authors: Sieranen Milla , Hilander Helena , Haimi Henri , Larsson Timo , Kuokkanen Anna , Mikola Anna 
Published: December 2023

Abstract

Nitrous oxide (N2O) is an ozone-depleting greenhouse gas that contributes significantly to the carbon footprint of a wastewater treatment plant (WWTP). Plant-specific measurement campaigns are required to reliably quantify the emission level that has been found to significantly vary between WWTPs. In this study, the N2O emissions were quantified from five full-scale WWTPs during 4–19-day measurement campaigns conducted under both cold period conditions (water temperature below 12 °C) and warm period conditions (water temperature from 12 to 20 °C). The measurement data were studied alongside long-term monitoring data from a sixth WWTP. The calculated emission factors (EFs) varied from near 0 to 1.8% relative to the influent total nitrogen load. The results confirmed a significant seasonality of N2O emissions as well as a notable variation between WWTPs in the emission level, which a single fixed EF cannot represent. Wastewater temperature was one explanatory factor for the emission seasonality. Both low and high emissions were measured from denitrifying–nitrifying activated sludge (AS) processes, while the emissions from only nitrifying AS processes were consistently high. Nitrite (NO2-) at the end of the aerobic zones of the AS process was linked to the variability in N2O emissions during the cold period.
Minimally Invasive Posterior Spinal Nonfusion Surgery in Patients With Adolescent Idiopathic Scoliosis Using a Bipolar One-Way Self-Expanding Rod System: Protocol for a Single-Center Clinical Cohort Study
Authors: Post Anne Mareille , Berends Hanneke I , van Royen Barend J 
Published: December 2023

Background
The current surgical treatment for patients diagnosed with progressive and severe adolescent idiopathic scoliosis (AIS) consists of the correction of the spinal curvature, followed by posterior spinal fusion (PSF). However, research has uncovered short- and long-term complications of posterior spinal fusion in patients with AIS. Minimally invasive growing rod techniques have successfully been used to treat patients with early-onset scoliosis and neuromuscular scoliosis. It may be questioned if minimally invasive posterior spinal nonfusion (PSnF) surgery with bipolar instrumentation can be used for the treatment of AIS.

Objective
This study will be performed to monitor the efficacy and safety of PSnF surgery by using a commercially available Conformité Européenne-certified spinal implant consisting of bilateral bipolar one-way self-expanding rods (OWSER) for the treatment of patients diagnosed with AIS.

Methods
In 14 selected patients with AIS with Lenke 1-6 curves, minimally invasive PSnF surgery with the OWSER system is performed after the failure of conservative treatment (curve progression of >5° within 1 year). The patients are over 7 years of age, with a major Cobb angle of ≥30°, sufficient flexibility, and a Risser stage of ≤2. Patients will be followed over time, according to the standard medical care. Efficacy will be measured using radiological and patient satisfaction assessments and safety will be determined by the amount of perioperative complications.

Results
Patient inclusion started on November 17, 2021 and we hope to finalize patient inclusion by the beginning of 2025. The first results will be expected by the beginning of 2024.

Conclusions
Minimally invasive PSnF in patients with AIS is presented as a less invasive surgical technique that prevents the progression of the scoliotic curve and that allows minor posture correction of coronal imbalance. This will be the first study to examine whether the PSnF bipolar OWSER instrumentation will be the next generation of surgical instrumentation in AIS.

Trial Registration
ClinicalTrials.gov NCT04441411; https://clinicaltrials.gov/study/NCT04441411

International Registered Report Identifier (IRRID)
DERR1-10.2196/47222
Capacity of Generative AI to Interpret Human Emotions From Visual and Textual Data: Pilot Evaluation Study
Authors: Elyoseph Zohar , Refoua Elad , Asraf Kfir , Lvovsky Maya , Shimoni Yoav , Hadar-Shoval Dorit 
Published: December 2023

Background
Mentalization, which is integral to human cognitive processes, pertains to the interpretation of one’s own and others’ mental states, including emotions, beliefs, and intentions. With the advent of artificial intelligence (AI) and the prominence of large language models in mental health applications, questions persist about their aptitude in emotional comprehension. The prior iteration of the large language model from OpenAI, ChatGPT-3.5, demonstrated an advanced capacity to interpret emotions from textual data, surpassing human benchmarks. Given the introduction of ChatGPT-4, with its enhanced visual processing capabilities, and considering Google Bard’s existing visual functionalities, a rigorous assessment of their proficiency in visual mentalizing is warranted.

Objective
The aim of the research was to critically evaluate the capabilities of ChatGPT-4 and Google Bard with regard to their competence in discerning visual mentalizing indicators as contrasted with their textual-based mentalizing abilities.

Methods
The Reading the Mind in the Eyes Test developed by Baron-Cohen and colleagues was used to assess the models’ proficiency in interpreting visual emotional indicators. Simultaneously, the Levels of Emotional Awareness Scale was used to evaluate the large language models’ aptitude in textual mentalizing. Collating data from both tests provided a holistic view of the mentalizing capabilities of ChatGPT-4 and Bard.

Results
ChatGPT-4, displaying a pronounced ability in emotion recognition, secured scores of 26 and 27 in 2 distinct evaluations, significantly deviating from a random response paradigm (P<.001). These scores align with established benchmarks from the broader human demographic. Notably, ChatGPT-4 exhibited consistent responses, with no discernible biases pertaining to the sex of the model or the nature of the emotion. In contrast, Google Bard’s performance aligned with random response patterns, securing scores of 10 and 12 and rendering further detailed analysis redundant. In the domain of textual analysis, both ChatGPT and Bard surpassed established benchmarks from the general population, with their performances being remarkably congruent.

Conclusions
ChatGPT-4 proved its efficacy in the domain of visual mentalizing, aligning closely with human performance standards. Although both models displayed commendable acumen in textual emotion interpretation, Bard’s capabilities in visual emotion interpretation necessitate further scrutiny and potential refinement. This study stresses the criticality of ethical AI development for emotional recognition, highlighting the need for inclusive data, collaboration with patients and mental health experts, and stringent governmental oversight to ensure transparency and protect patient privacy.
A Patient with 38 Years of Smoking History and Severe Shortness of Breath
Authors: Buklis E. R. , Kokina N. I. , Bueverova E. L. , Feldsherov M. V. , Komarova V. S. , Ivashkin V. T. 
Published: December 2023

Aim: to present a clinical case of post-COVID bronchiolitis in an adult.Key points. A 54-year-old female patient with a long history of smoking was hospitalized in the pulmonology department of the Clinic with a leading complaint of progressive shortness of breath after a COVID-19 infection. The diagnosis was established: bilateral bronchiolitis associated with a new coronavirus infection (SARS-CoV-2 polymerase chain reaction — positive); chronic obstructive pulmonary disease stage II according to GOLD (Global Initiative for Chronic Obstructive Lung Disease), exacerbation. Against the background of the therapy, there was a significant positive dynamics in well-being and in CT-picture of bronchiolitis. The patient was discharged for outpatient follow-up treatment. One of the most common symptoms of post-COVID syndrome is shortness of breath. Diagnosis of bronchiolitis, in which this symptom may be the only one, is difficult, especially in patients with a long history of smoking and the presence of comorbid pulmonary pathology.Conclusion. A clinical case of bilateral bronchiolitis in the framework of the post-COVID syndrome is presented. The key to successful diagnosis of bronchiolitis is a thorough differential analysis of the totality of anamnestic and clinical laboratory data, as well as a characteristic CT pattern.
Analytical Approach to the Selection of Research Topics for Gallstone Disease and Acute Cholecystitis (an Overview of Cochrane Reviews)
Authors: Panin S. I. , Nechay T. V. , Sazhin A. V. , Puzikova A. V. 
Published: December 2023

Aim: description of modern methods of statistical evaluation of the world evidence base to determine the direction of promising scientific research in diagnosis and treatment of cholelithiasis and cholecystitis.Materials and methods. The umbrella review of systematic reviews and meta-analyses of the Cochrane Library has been conducted, identifying topics for which further evidence-based research is needed. The information obtained by the Cochrane expert panels through Trial Sequential Analysis (TSA), Diversity-Adjusted Required Information Size (DARIS) calculations, and Z-curve monitoring on benefit, harm, or futility boundary plots is systematized.Results. There were established multidirectional trends and significantly different levels of achievement of evidence-based results. These should be taken into account when determining the prospect of further evidence-based studies. In the context of bile duct injury between early and delayed laparoscopic cholecystectomy, number of complications between early and delayed laparoscopic cholecystectomy, small-incision cholecystectomy and laparoscopic cholecystectomy, single-port and standard four-ports cholecystectomy and low-pressure laparoscopy the required size of meta-analysis information is unlikely to be achieved — in current versions of Cochrane library DARIS is less than 1 % of required. The same applies to mortality, the probability of developing serious complications and the conversion rate of various minimally invasive procedures, as the required sample sizes (hundreds of thousands of observations) are difficult to achieve — currently range is from 0.03 to 21.9 %. On the contrary, the achieved values from the estimated DARIS in establishing the differences in the duration between minimally invasive surgery options (21.2 to 76 %), in some issues of pain management in the immediate postoperative period (43.6 to 92.6 %) and additional intraoperative anesthesia (13.7 to 14.9 %) and Z-curve monitoring give hope for their achievement in the foreseeable future. There is little prospect of continuing evidence-based studies to determine the need for intraperitoneal anesthetic instillation, differences in the duration of hospitalization after various minimally invasive surgeries, since new information is unlikely to change the conclusions of meta-analyses (the required information size has been achieved by 100 %).Conclusion. It is necessary to take into account the results of a TSA analysis of Cochrane expert groups, when choosing research topics in patients with gallstone disease and acute cholecystitis.
COVID-19 Pandemic and IBS. Results of the All-Russian Observational Non-interventional Program to Study the Effectiveness of the Drug Kolofort® in Real Clinical Practice in Patients with Irritable Bowel Syndrome After a New Coronavirus Infection (VESNA)
Authors: Ivashkin V. T. , Abdulkhakov R. A. , Bakulin I. G. , Zaitsev S. V. , Luchina V. I. , Mekhtiyev S. N. , Peshekhonov S. G. , Poluektova E. A. , Semenova T. I. , Serikova S. N. , Tarasova G. N. , Trush E. A. , Uspenskiy Y. P. , Khlynov I. B. , Tsukanov V. V. , Chernus N. P. 
Published: December 2023

Aim: to study the effectiveness and safety of using the drug Kolofort® in outpatients with irritable bowel syndrome (IBS) after a new coronavirus infection.Materials and methods. An observational non-interventional program was conducted in patients with exacerbation of IBS symptoms after a new coronavirus infection. One hundred forty-one patients took part in the study. The final efficacy analysis included data from 127 study participants. All patients complained of increased/appearing gastrointestinal symptoms that appeared within 1–6 months after the infection (all patients had a history of COVID-19 infection). To assess the presence and severity of symptoms of the disease, the “7 × 7” questionnaire was used before the start of treatment and three months after the start of treatment.Results. At the stage of inclusion in the program, the average total score on the “7 × 7” questionnaire was 17.36, which corresponded to a moderately severe disorder. During the treatment period, the average total score decreased to 6.14, which corresponded to borderline disorder. In addition, significant improvement was observed for each symptom separately. After three months of therapy, doctors rated the overall impression of the treatment on a 5-point Likert scale from “very effective” to “ineffective”. The average score was 4.24. In addition, no serious adverse events were identified while taking the drug.Conclusion. In real clinical practice, the drug Kolofort® demonstrated high clinical efficacy in the treatment of patients with IBS after COVID-19 infection.
The Use of L-Menthol in Endoscopic Transpapillary Interventions. Prospective Randomized Dual-Center Study
Authors: Anishchenko M. A. , Nazmeev M. A. , Shapovalyants S. G. , Budzinsky S. A. , Rogov A. V. , Zaynutdinov R. R. , Melnikova A. S. , Fedorov E. D. , Platonova E. N. 
Published: December 2023

Aim: to study the effect of L-menthol on duodenal peristalsis, the results of cannulation of the papilla, the effectiveness and safety of endoscopic retrograde transpapillary interventions (ERTI).Materials and methods. A prospective two-center randomized placebo-controlled trial was carried out from January to November 2022 in two centers. The study included 126 patients, 69 (54.8 %) men and 57 (45.2 %) women, mean age — 62.1 ± 1.8 years. The inclusion criteria were age 18–75 years, indications for ERTI, absence of previous endoscopic papillotomy, absence of allergy to menthol, consent to participate in the study. After randomization, the main group (“L”) included 70 patients, the control group — 56. Patients in group “L” were irrigated with 25 mL (160 mg) of L-menthol (Spectavium), patients in the control group — with 25 mL of saline solution. Peristaltic activity was studied before and three minutes after administration of the drug. The intensity of peristalsis was assessed according to a modified Hiki scale: 0 points — complete absence of peristalsis; 1 point — single peristaltic waves; 2 points — intense peristalsis, little amenable to straightening at maximum insufflation; 3 points — pronounced peristalsis.Results. Three minutes post-irrigation, the suppression of peristaltic waves was noted in the experimental group “L”: 0 points — 63 (90 %) patients, 1 point — 6 (8.6 %) patients, compared to the control, with no change in peristalsis (p < 0.05). Successful selective cannulation was achieved in 64 (91.4 %) patients of group “L” and in 41 (73.2 %) — of the control group (p < 0.05). Non-cannulation endoscopic papillotomy had to be used in 6 (8.5 %) cases in group “L” and in 14 (25 %) cases in the control group. In general, successful cannulation was achieved in 100 % of patients in group “L”, and in 94.5 % — in the control group (p < 0.05). The duration of the intervention was significantly reduced in group “L” — 40 ± 2.5 vs. 50.3 ± 3.6 min. Among the complications, only intraoperative bleeding was registered (2 (2.9 %) — group “L”, 5 (8.9 %) — the control group), which was eliminated endoscopically in all cases.Conclusion. The use of L-menthol during ERTI helps to achieve noticeable inhibition of peristalsis, promotes successful cannulation, reduces the intervention time, minimizes the risk of intraoperative complications. Thus, L-menthol has demonstrated its effectiveness and safety, which makes it possible to use it in the arsenal of combating enhanced peristalsis during ERTI.
Long-Term Results of Medical and Surgical Methods for Elimination of the Internal Anal Sphincter Spasm in Chronic Anal Fissure (NCT03855046)
Authors: Achkasov S. I. , Khryukin R. Yu. , Zharkov E. E. , Ponomarenko A. A. , Fomenko O. Yu. , Klopkov N. I. , Kamaeva Z. Z. , Lebedeva E. Yu. , Sagidova K. I. 
Published: December 2023

Aim: evaluation of long-term results of injection of botulinum toxin type A into the internal anal sphincter and performing lateral internal sphincterotomy in combination with excision of chronic anal fissure.Materials and methods. The study included 176 patients (73 (41.5 %) men and 103 (58.5 %) women) older than 18 years; randomization into the compared groups was carried out by random number generation in a computer program. Patients, researchers and surgeons were not blinded. Patients of the main group underwent fissure excision in combination with relaxation of the internal anal sphincter by botulinum toxin type A (BTA) at a dosage of 40 units, patients of the control group underwent lateral internal sphincterotomy (LIS) with excision of chronic anal fissure. Long-term results of complex treatment were studied in 126 patients (54 (43 %) men and 72 (57 %) women), the median follow-up was 12.3 (12.2; 15.7) months. Statistical analysis was carried out in the program Statistica 13.3 (TIBCO Software Inc., USA).Results. In the long-term postoperative period, the indicators of mean resting anal pressure were lower in the LIS group (p = 0.04). The compared groups were comparable in terms of the level mean squeeze anal pressure (p = 0.69); however, in patients of the BTA group, the level of this indicator increased over time (p = 0.001). None of the patients of the compared groups had anal incontinence and relapse of the disease.Discussion. In the framework of the performed study, in some patients from the compared groups, spasm of the internal anal sphincter persisted throughout the observation period, and in some patients it occurred again, while no signs of relapse fissure were detected. The functional and clinical results of treatment obtained by us cast doubt on the exclusivity of the increased tone of the internal anal sphincter as the main link in the pathogenesis of chronic anal fissure in some patients and indicates the presence of other factors in combination with which the course of the disease is determined. The above facts do not exclude the possibility of recurrence of anal fissure in a more distant period of observation.Conclusion. Medical relaxation with botulinum toxin type A at a dosage of 40 units can serve as an alternative to lateral internal sphincterotomy as a method of eliminating spasm of the internal anal sphincter
Understanding the Reliability of the Complex System Having Two Standby Units: A Transdisciplinary Approach
Authors: Zaidi Zeenat 
Published: December 2023

The main objective of this study is to thoroughly investigate the reliability of a complex system that consists of four components and two standby units. The complicated system is modeled using the Markov technique. The study formulates differential equations and solves them using a matrix method with the assistance of a computer program. Statistical methods, such as correlation and regression, are applied using SPSS software to understand the relationship between time and the reliability of this complex system. A statistical model is utilized to determine the system's reliability, identify potentially faulty components, and prioritize the protection of the most critical elements. The presentation of significant findings involves conducting a comprehensive analysis using tables and graphs created with Python programming language. The outcomes of this study aim to assist in identifying crucial units in various process industries, thereby facilitating the establishment of effective management policies and strategies for the optimal operation of complex and large-scale systems in the industry. This paper incorporates numerous disciplines, viewpoints, and methodologies to examine and enhance reliability in process industries. Reliability can indeed benefit from a matrix approach, which can be considered transdisciplinary. This study serves as both an introductory guide to reliability analysis for novice researchers and a survey highlighting the latest advancements in the field for experienced researchers.
ОПЫТ ЭКСПЕРТНОГО ВЗАИМОДЕЙСТВИЯ МЕЖДУ ПАТЕНТНЫМИ ВЕДОМСТВАМИ МИРА
Authors: Журавлев Андрей , Дарина Ольга 
Published: December 2023

На сегодняшний день существуют несколько программ экспертного взаимодействия между национальными патентными ведомствами мира (НПВ), региональными европейскими ведомствами (ЕПВ, ЕАПВ) и Международным бюро Всемирной организации интеллектуальной собственности (МБ ВОИС). Изучение опыта практической работы в рамках таких международных программ взаимодействия станет основой создания новых механизмов взаимодействия между экспертами национальных патентых ведомств в евразийском регионе. Роспатент и Евразийское патентное ведомство (ЕАПВ) проводят совместную работу по созданию основ единого евразийского патентного экспертно-информационного пространства для целей оказания более качественных патентых услуг по охране ОИС для всех заявителей евразийского региона.
В статье представлен аналитический обзор международных механизмов взаимодействия экспертов ведущих патентых ведомств мира. Проанализированы перспективы использования этих механизмов экспертного взаимодействия в работе патентных ведомств (ПВ) стран- членов Евразийской патентной Конвенции (ЕПК). Статья написана в рамках НИР: 2-ПО-2023 «Организационно-правовые аспекты формирования единого экспертно-информационного пространства в сфере промышленной собственности в евразийском регионе»