bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Kegel Motion Combined With Warming Acupuncture at the Eight Acupuncture Points in Patients With Urinary Incontinence After Radical Prostatectomy
Authors: Chen Hui , Wang Chenchen , Zhang Zhongqing , Hao Lingling , Qiu Xuefeng , Xu Linfeng , Zhuang Junlong , Guo Hongqian 
Published: December 2023

Purpose
To study the effect of Kegel exercise combined with Baliao warming acupuncture in the treatment of urinary incontinence after radical prostatectomy.

Methods
A single-center, retrospective cohort study was conducted on patients with clinically localized prostate cancer. This study involved 200 patients through a specific exclusion criterion admitted to the Department of Urology of our hospital, including 100 cases in the control group (single Kegel Motion) and 100 cases in the experimental group (Kegel Motion combined with acupuncture) from July 2017 to November 2020. Time from catheter removal to full recovery of urinary continence was recorded by 1 month, 3 months, and 6 months after surgery. The International Consultation on Incontinence Questionnaire-Short Form, the “1-hour diaper test,” and the Quality of Life Incontinence Questionnaire were used to evaluate the frequency and severity of urinary incontinence, the efficacy of urinary incontinence and the patients’ qualities of life, respectively. An independent sample t test, rank sum test, and χ2 test were adopted for comparison between groups.

Results
None of the frequency, severity, and efficacy of urinary incontinence nor the patients’ qualities of life showed a difference between the experimental group and the control group at 1 month after surgery (P &gt; 0.05) but showed significant differences at 3 months and 6 months postoperatively (P &lt; 0.05).

Conclusions
The Kegel Motion combined with warming acupuncture at the 8 acupuncture points can reduce the incidence of urinary incontinence, improve urinary control ability, and improve the quality of life of patients with urinary incontinence after radical prostatectomy.
A Highly Soluble Iron‐Based Posolyte Species with High Redox Potential for Aqueous Redox Flow Batteries
Authors: Gao Jinxu , Lee Kyumin , Amini Kiana , Gordon Roy G. , Betley Theodore A. , Aziz Michael J. 
Published: December 2023

AbstractA novel iron‐based posolyte redox species are presented for an aqueous redox flow battery, (Tetrakis(2‐pyridylmethyl)ethylenediamine)iron(II) dichloride, which is obtained by a simple synthetic route, shows a high redox potential of 0.788 V versus SHE, and exhibits exceptional aqueous solubility of 1.46 M. Paired with bis(3‐trimethylammonio)propyl viologen tetrachloride at neutral pH, the battery demonstrates an open‐circuit voltage of 1.19 V and delivers good cycling performance, with a capacity fade rate of 0.28% per day and coulombic efficiency of 99.3%. Postmortem chemical and electrochemical analyses of the posolyte species suggest future routes for stabilization of the complex. Among all the iron complexes with a redox potential above 0.4 V versus SHE, this compound exhibits the highest solubility. These results offer valuable insights that can be applied to the development of future posolyte species for sustainable energy storage solutions.
Tissue and Cell Dual‐Penetrating Dendritic Lipopeptide Liposomes for Hypertrophic Scar Treatment
Authors: Lei Lei , Wang Xulei , Zhou Yinhui , Cong Rui , Zhou Sensen , Gao Rongfang , Tu Jiasheng , Jiang Xiqun , Jiang Lei 
Published: December 2023

AbstractHypertrophic scar is a complex global disease, which can lead to remarkable functional impairment, pruritus, and pain. Treating local skin diseases needs a transdermal drug delivery system that can simultaneously promote cell and tissue penetration within the hypertrophic scar. Herein, a tissue and cell dual‐penetrating liposomal delivery platform consisting of arginine‐based dendritic lipopeptide mimicking the pivotal amino acid sequence in viral protein transduction domains and virion‐like nanostructure to enhance hypertrophic scar tissue deep penetration and cellular internalization is reported. This dendritic lipopeptide liposomal delivery platform can overcome corneum barriers to the punch on hypertrophic scar fibroblast membranes, as are natural viruses. It also can deeply deliver drugs to promote hypertrophic scar fibroblast apoptosis and collagen fiber remodeling within thickened dermis and epidermis, and finally remove the raised scars.
Regulating the Band Structure of Ni Active Sites in Few‐Layered Nife‐LDH by In Situ Adsorbed Borate for Ampere‐Level Oxygen Evolution
Authors: Zhou Shunfa , He Huawei , Li Jing , Ye Zihao , Liu Zhao , Shi Jiawei , Hu Yang , Cai Weiwei 
Published: December 2023

AbstractRealizing rapid transformation of hydroxide to high‐active oxyhydroxide species in layered double hydroxide (LDH) catalyst plays a significant role in enhancing its activity toward oxygen evolution reaction (OER) for hydrogen production from water. Here, a scalable strategy is developed to synthesize defect‐rich few‐layered NiFe‐LDH nanosheets (f‐NiFe‐LDH‐B) with in situ borate modified for boosted and stable OER due to that the borate can narrow the bandgap for Ni sites to realize a more conductive electronic structure. Besides, the adsorbed borate can tune the d band center of Ni sites to promote of hydroxide transformation and facilitate the adsorption of the OER intermediates. The f‐NiFe‐LDH‐B catalyst, therefore, requires only 209 and 249 mV overpotential to deliver 10 and 100 mA cm−2 OER, respectively, with a Tafel slope of 43.5 mV dec−1. Moreover, only 1.8 V cell voltage is required to reach Ampere‐level overall water splitting for 500 h at room temperature.
Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety Assessments
Authors: Kemas Aurino M. , Zandi Shafagh Reza , Taebnia Nayere , Michel Maurice , Preiss Lena , Hofmann Ute , Lauschke Volker M. 
Published: December 2023

AbstractOrganotypic and microphysiological systems (MPS) that can emulate the molecular phenotype and function of human tissues, such as liver, are increasingly used in preclinical drug development. However, despite their improved predictivity, drug development success rates have remained low with most compounds failing in clinical phases despite promising preclinical data. Here, it is tested whether absorption of small molecules to polymers commonly used for MPS fabrication can impact preclinical pharmacological and toxicological assessments and contribute to the high clinical failure rates. To this end, identical devices are fabricated from eight different MPS polymers and absorption of prototypic compounds with different physicochemical properties are analyzed. It is found that overall absorption is primarily driven by compound hydrophobicity and the number of rotatable bonds. However, absorption can differ by >1000‐fold between polymers with polydimethyl siloxane (PDMS) being most absorptive, whereas polytetrafluoroethylene (PTFE) and thiol‐ene epoxy (TEE) absorbed the least. Strikingly, organotypic primary human liver cultures successfully flagged hydrophobic hepatotoxins in lowly absorbing TEE devices at therapeutically relevant concentrations, whereas isogenic cultures in PDMS devices are resistant, resulting in false negative safety signals. Combined, these results can guide the selection of MPS materials and facilitate the development of preclinical assays with improved translatability.
Use of Field Concentration for Electroluminescent Devices
Authors: Vaicekauskaite Justina , Yang Canhui , Dam‐Hansen Carsten , Yu Liyun , Suo Zhigang , Skov Anne Ladegaard 
Published: December 2023

AbstractField concentration is often regarded as a problematic issue in soft electronics applications, especially when using curved electrodes, and in particular, those with sharp edges. However, field concentration can be turned into an advantage with appropriate device design. Herein, the applications of field concentration in hydrogel‐elastomer devices are explored. Three different types of electroluminescent hydrogel‐elastomer devices are fabricated using different types of electrodes and different light patterns. In addition, the effect of the field concentration can be extended into the bulk of the elastomer by preparing porous silicone elastomers and filling them with silicone oil. These devices are shown to be flexible and possess both good luminance and a long lifetime.
Synthetic Biohybrids of Red Blood Cells and Cascaded‐Enzymes@ Metal–Organic Frameworks for Hyperuricemia Treatment
Authors: Li Zeyu , Xue Liecong , Yang Junxian , Wuttke Stefan , He Peiying , Lei Chuanyi , Yang Haowei , Zhou Liang , Cao Jiangfan , Sinelshchikova Anna , Zheng Guansheng , Guo Jimin , Lin Jiangguo , Lei Qi , Brinker C. Jeffrey , Liu Kaisheng , Zhu Wei 
Published: December 2023

AbstractHyperuricemia, caused by an imbalance between the rates of production and excretion of uric acid (UA), may greatly increase the mortality rates in patients with cardiovascular and cerebrovascular diseases. Herein, for fast‐acting and long‐lasting hyperuricemia treatment, armored red blood cell (RBC) biohybrids, integrated RBCs with proximal, cascaded‐enzymes of urate oxidase (UOX) and catalase (CAT) encapsulated within ZIF‐8 framework‐based nanoparticles, have been fabricated based on a super‐assembly approach. Each component is crucial for hyperuricemia treatment: 1) RBCs significantly increase the circulation time of nanoparticles; 2) ZIF‐8 nanoparticles‐based superstructure greatly enhances RBCs resistance against external stressors while preserving native RBC properties (such as oxygen carrying capability); 3) the ZIF‐8 scaffold protects the encapsulated enzymes from enzymatic degradation; 4) no physical barrier exists for urate diffusion, and thus allow fast degradation of UA in blood and neutralizes the toxic by‐product H2O2. In vivo results demonstrate that the biohybrids can effectively normalize the UA level of an acute hyperuricemia mouse model within 2 h and possess a longer elimination half‐life (49.7 ± 4.9 h). They anticipate that their simple and general method that combines functional nanomaterials with living cell carriers will be a starting point for the development of innovative drug delivery systems.
Solution‐Processed PTCDI‐C8 Crystalline Wire: Dual Role as Mask and Active Layer for Organic Transistors with Increased Switching Speeds
Authors: Choi Bogyeong , Kwon Dongyub , Tarsoly Gergely , Park Junyong , Pyo Seungmoon 
Published: December 2023

AbstractOrganic field‐effect transistors (OFETs) have been extensively studied over the past decades because of their suitability for low‐cost, large‐area, and flexible electronics. However, improvements are needed to satisfy the demands of high‐speed applications. The switching speed of a logic device is affected by the charge‐carrier mobility (µ) and the square of the channel length (L) at a given gate–source bias. Therefore, increasing µ and/or reducing L are crucial for achieving high‐speed OFET‐based digital circuits. In this study, an n‐type OFET is fabricated with increased switching speed via a dual‐role approach involving solution‐grown, highly ordered single‐crystalline N,N'‐dioctyl‐3,4,9,10‐perylenetetracarboxylic diimide (PTCDI‐C8) wires, which serve as a mask for short‐channel formation up to the microscale and an active layer with enhanced charge mobility. Additionally, the performance of the n‐type short‐channel OFET and resistive‐load‐type inverters is evaluated. For comparative purposes, long‐channel (50 µm) devices with PTCDI‐C8 wires and short‐channel devices with a PTCDI‐C8 film are fabricated and the device performance is analyzed. The short‐channel device with the PTCDI‐C8 wires exhibits a significantly higher switching speed. Thus, the dual‐role approach is a simple and straightforward method for fabricating short‐channel devices, paving the way for further advancements in OFET technology requiring high switching speeds.
Exploring Multi‐Bit Logic In‐Memory with Memristive HfO2‐Based Ferroelectric Tunnel Junctions
Authors: Kho Wonwoo , Hwang Hyunjoo , Ahn Seung‐Eon 
Published: December 2023

AbstractThe increasing demand for data movement and energy consumption in physically separate von Neumann architectures, where the processor and memory are distinct entities, highlights the severity of the memory‐wall problem. Thus, memristor‐based logic‐in‐memory (LiM) has garnered significant interest as it is a paradigm that enables both logic and memory functionalities to be performed within a single device. Ferroelectric tunnel junctions (FTJs) have the advantages of low energy consumption and high scalability; thus, they are particularly appropriate for use as analog memristors in LiMs. Precise and accurate programming of the analog resistance states in FTJs is essential to achieve an efficient memristor‐based LiM design. However, existing switching models for FTJs cannot completely consider the ferroelectric domain switching, which challenges multi‐bit LiM operations. This particularly applies in cases involving updates from one intermediate resistance state (IRS) to another IRS, such as transitioning from State 01 to 10 in 2‐bit LiM. In this study, a novel phenomenon associated with domain switching is observed in the IRS of an HZO FTJ device and applied it to an LiM implementation. These findings can contribute to the operational accuracy and update rules of not only FTJ‐based LiMs but also other FTJ applications, such as crossbar arrays.
Electrochemical Activation of Ordered Mesoporous Solid Electrolyte Interphases to Enable Ultra‐Stable Lithium Metal Batteries
Authors: Gu Yuping , Hu Jiulin , Lei Meng , Li Wenbo , Li Chilin 
Published: December 2023

AbstractIn Li metal batteries, the rational construction of artificial solid electrolyte interphase (ASEI) can homogenize the Li‐ion flowing and Li‐mass plating/stripping, and reinforce the mechanical and electrochemical stabilities of electrode–electrolyte interface. Here, an ordered‐mesoporous powder zirconium oxophosphate (ZrOP) is proposed to construct a Li‐ion conductive ASEI by brushing ZrOP on metallic Li. The P‐induced amorphization in ZrOP is expected to accelerate the spontaneous lithiation reaction and promote the generation of P‐contained Li‐ion conductors and LiF domains in ASEI during Li anode cycling. The electrochemical activation of ASEI with promoted ionic conductivity and interconnected porous network is favorable for the homogeneous nucleation and growth of Li metal grains (with ≈10 µm in size), and the suppression of Li dendrites and volume expansion during long‐term Li plating and stripping. The ZrOP‐modified Li symmetric cell enables a long lifespan of over 1600 h at 1 mA cm−2, and the corresponding LiNi0.8Co0.1Mn0.1O2 (NCM811) based full cell displays a stable cycling for at least 300 cycles with a capacity retention of 80% at 1 C. The modified thin Li foil (40 µm in thickness) anode also enables a multilayered pouch cell based on a high‐loading NCM811 cathode with stable cycling and reversible capacity over 1 Ah.
Unraveling the Fast Na Diffusion Kinetics of NASICON at High Voltage via High Entropy for Sodium‐Ion Battery
Authors: Ahsan Muhammad Tayyab , Qiu Daping , Ali Zeeshan , Fang Zhi , Zhao Wanting , Shen Tong , Hou Yanglong 
Published: December 2023

AbstractVanadium based sodium superionic conductors (NASICON) have attracted unpreceded attention owing to their high structural stability and excellent Na+ ion diffusion. However, Na4VM(PO4)3 suffer from low‐rate capability and capacity decay at high voltage (≈4.0 V) due to low electronic conductivity and irreversible phase transition of V4+/V5+. Herein, a high entropy Na4VFe0.6Mn0.2Cr0.1(CoMgAl)0.1(PO4)3 (NVFP‐HE) NASICON material is designed, which allows the intrinsic effect of multi‐metal to achieve the excellent rate capability at high voltage, good ionic as well as electronic conductivity. This NVFP‐HE cathode not only delivers a high discharge capacity of 141.98 mAh g−1 at 1C, but also presents an exceptional capacity of 85.77 mAh g−1 at as high as 50C current rate. Additionally, NVFP‐HE can also retain 66.7% of initial capacity after 10 000 charge–discharge cycles at 50C. It is important to highlight that the high entropy mitigates the performance decay that arises from the irreversible phase change at 4 V. Interestingly, NVFP‐HE//HC full cell delivers 81 mAh g−1 at 0.2C. This high entropy effect and its proof of concept can allow to look for unique combinations and rationally designed advanced cathode materials for wide applications.
Excessive mind wandering, rumination, and mindfulness mediate the relationship between ADHD symptoms and anxiety and depression in adults with ADHD
Authors: Kandeğer Ali , Odabaş Ünal Şerife , Ergün Muhammed Tuğrul , Yavuz Ataşlar Emine 
Published: December 2023

AbstractBackgroundPersistent mind‐wandering processes are associated with negative emotions; however, mindful states exhibit an anticorrelation with mind‐wandering patterns. The aim of this study is to investigate the mediating role of excessive mind wandering (EMW), rumination, and trait mindfulness between attention‐deficit hyperactivity disorder (ADHD) symptoms and the severity of anxiety/depression in adults with ADHD.MethodsMedication‐free 159 adults diagnosed with ADHD completed a test battery that included a sociodemographic form as well as the Adult ADHD Severity Rating Scale, Hospital Anxiety Depression Scale, Mind Excessively Wandering Scale, Ruminative Response Scale, and Freiburg Mindfulness Inventory after the diagnostic examination according to the Structured Clinical Interview for DSM‐5–Clinician Version (SCID‐5).ResultsADHD symptoms exhibited an indirect, but not a direct, association with the severity of anxiety and depression, mediated by increased excessive mind wandering and rumination, as well as decreased trait mindfulness.LimitationsThis study was carried out within a clinical population using a cross‐sectional design. While diagnostic assessments were conducted using SCID‐5, psychiatric symptoms were evaluated through self‐report measures.ConclusionsCoping with EMW and rumination and promoting mindfulness ability may be promising targets in treating comorbid conditions in adults with ADHD. These findings have highlighted the effects of mentation processes on depression and anxiety, which are common comorbidities with ADHD in adults; however, longitudinal studies are needed.
Green Synthesis of 3‐Alkylidenefuran‐2‐ones by Palladium‐Catalyzed Cyclocarbonylation of Aryl Iodides with Benzyl Acetylenes in 2‐MeTHF
Authors: Zhan Jianan , Chen Junmin , Wei Li , Cai Mingzhong 
Published: December 2023

AbstractA novel, highly efficient heterogeneous palladium‐catalyzed carbonylative cyclization of aryl iodides and benzyl acetylenes has been developed under an atmospheric pressure of CO. The reaction proceeds smoothly in a bioderived solvent 2‐methyltetrahydrofuran (2‐MeTHF) at 50 °C using an MCM‐41‐anchored bidentate phosphine palladium complex [Pd(OAc)2‐MCM‐41‐P,P] as catalyst with DiPEA as base, delivering a wide variety of 3‐alkylidenefuran‐2‐ones in good to excellent yields. The Pd(OAc)2‐MCM‐41‐P,P complex can be easily recovered by a simple centrifugation and recycled more than ten times without any remarkable loss of catalytic activity. The present method not only avoids the use of toxic solvents such as benzene, toluene and THF, but also addresses the key problem of expensive palladium catalyst recovery and recycle, thus preventing palladium contamination in the final product.
Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway
Authors: Tu Zhenzhen , Wei Wei , Xiang Qiantong , Wang Wenwen , Zhang Siping , Zhou Haisheng 
Published: December 2023

AbstractThe transcription factor LIM‐only protein 4 (LMO4) is overexpressed in the psoriatic epidermis and regulates keratinocyte proliferation and differentiation. High LMO4 expression levels are induced by interleukin‐23 (IL‐23) to activate the AKT/STAT3 signaling pathway. Interleukin‐6 (IL‐6) is mainly involved in regulating T cell functions and development in patients with psoriasis. However, whether LMO4 expression is regulated by IL‐6 remains unclear. Therefore, the purpose of this study is to explore the role and molecular mechanisms of IL‐6 in regulating LMO4 expression. The interleukin‐6 (IL‐6) levels in human plasma were determined using a chemiluminescence immunoassay system. A psoriasis‐like mouse model was established using imiquimod induction. Epidermal keratinocytes (HaCaT) were cultured in defined keratinocyte‐serum‐free medium and stimulated by IL‐6 alone or with inhibitors. The proteins of interest were detected using western blot analysis, immunofluorescence, and immunohistochemistry. The 5‐ethynyl‐2′‐deoxyuridine assay was used to detect cell proliferation. The results revealed that IL‐6 levels were markedly increased in the plasma of patients with psoriasis, compared to healthy control. The high expression of LMO4 was consistent with high levels of IL‐6, p‐AKT, and p‐STAT3 in the lesions of both psoriasis patients and imiquimod‐induced psoriasis‐like mice. IL‐6 activates the AKT/STAT3 signaling pathway, followed by LMO4 high‐expression in HaCaT cells. IL‐6 induces HaCaT proliferation and differentiation via AKT/STAT3 signaling pathway activation. We think that the high expression of LMO4 in psoriatic keratinocytes requires IL‐6 to activate the AKT/STAT3 signaling pathway and leads to epidermal keratinocytes abnormal proliferation and differentiation.
Hyperglycemia disrupted the integrity of the blood‐brain barrier following diffuse axonal injury through the sEH/NF‐κB pathway
Authors: Wei Xing , Xing Zhiguo , Huang Tingqin , Zhang Ming , Song Jinning , Zhao Yonglin 
Published: December 2023

AbstractObjectivesWe aimed to investigate the role of soluble epoxide hydrolase for hyperglycemia induced‐disruption of blood‐brain barrier (BBB) integrity after diffuse axonal injury (DAI).MethodsRat DAI hyperglycemia model was established by a lateral head rotation device and intraperitoneal injection of 50% glucose. Glial fibrillary acidic protein, ionized calcium‐binding adapter molecule‐1, β‐amyloid precursor protein, neurofilament light chain, and neurofilament heavy chain was detected by immunohistochemistry. Cell apoptosis was examined by terminal deoxynucleotidyl transferase nick‐end labeling (TUNEL) assay. The permeability of blood‐brain barrier (BBB) was assessed by expression of tight junction proteins, leakage of Evans blue and brain water content. The soluble epoxide hydrolase (sEH) pathway was inhibited by 1‐trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl) urea (TPPU) and the nuclear transcription factor kappa B (NF‐κB) pathway was inhibited by pyrrolidine dithiocarbamate and activated by phorbol‐12‐myristate‐13‐acetate in vivo and/or vitro, respectively. The inflammatory factors were detected by enzyme‐linked immunosorbent assay.ResultsHyperglycemia could exacerbate axonal injury, aggravate cell apoptosis and glial activation, worsen the loss of BBB integrity, increase the release of inflammatory factors, and upregulate the expression of sEH and NF‐κB. Inhibition of sEH could reverse all these damages and protect BBB integrity by upregulating the expression of tight junction proteins and downregulating the levels of inflammatory factors in vivo and vitro, while the agonist of NF‐κB pathway abrogated the protective effects of TPPU on BBB integrity in vitro.ConclusionssEH was involved in mediating axonal injury induced by hyperglycemia after DAI by disrupting BBB integrity through inducing inflammation via the NF‐κB pathway.