bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive Terpenoids and Guggulusteroids from Commiphora mukul Gum Resin of Potential Anti‐Inflammatory Interest
Authors: Francis Jayaraj A. , Raja Srinivasa N. , Nair Muraleedharan G. 
Published: November 2004

AbstractGuggulu, the gum resin from Commiphora mukul, is one of the components of various formulations of traditional Ayurvedic medicine to treat inflammation, obesity, and lipid disorders. In most preparations of Ayurvedic medicine in India, guggulu is boiled prior to its use. Therefore, guggulu was boiled with H2O prior to extractions in our study. Bioassay‐guided isolation of compounds from the hexane‐soluble portion of the MeOH extract of guggulu yielded cembrenoids, 1–6, a bicyclic diterpene, 7, guggulusterone derivatives, 8–11, myrrhanone derivatives, 12, myrrhanol derivative, 13, and a lignan, 14. The structures of these compounds were confirmed by spectroscopic methods. Compounds 5, 6, 7, 10, and 12–14 are novel. These compounds were assayed for lipid peroxidation and cyclooxygenase (COX) enzyme inhibitory activities. At 100 ppm, compounds 3, 6, and 14 inhibited the lipid peroxidation by 79, 57, and 58%, respectively, and the rest of isolated compounds showed 20–40% inhibitory activity with respect to the controls. In COX‐1 and COX‐2 enzyme inhibitory assays, compound 3 showed 79 and 83%, and compound 8 gave 67 and 54% of inhibition, respectively, at 100 ppm. All fourteen compounds inhibited COX‐1 enzyme at 100 ppm. The lipid peroxidation and COX enzyme inhibitory activities exhibited by compounds isolated from C. mukul may substantiate its use in traditional medicine.
Validation of a new formula for mean arterial pressure calculation: The new formula is superior to the standard formula
Authors: Razminia Mansour , Trivedi Atul , Molnar Janos , Elbzour Monther , Guerrero Mayra , Salem Yasser , Ahmed Aziz , Khosla Sandeep , Lubell David L. 
Published: November 2004

AbstractMean arterial pressure (MAP) has traditionally been derived from systolic and diastolic pressures, weighted 1/3 systolic and 2/3 diastolic. No correction is made for the increasing time dominance of systole with increasing heart rates. In a previous study, we developed a new and more accurate heart rate‐corrected MAP formula from central aorta pressure determinations in a large number of patients: MAP = DP + [0.33 + (HR × 0.0012)] × [PP] where SP and DP are systolic and diastolic pressure and HR is heart rate. The current study validates the new MAP formula in the same patient at increasing paced heart rates. A central aorta catheter was used to obtain computer‐determined systolic, diastolic, and MAP in 12 patients. Values were obtained at baseline and then at increasing right atrial paced heart rates. The new and standard MAP formula‐derived values were compared with computer‐determined values. The new formula showed a much closer correlation with the computer‐derived values for MAP. Standard MAP calculations for MAP can easily be improved by inclusion of a heart rate factor. Catheter Cardiovasc Interv 2004;63:419–425. © 2004 Wiley‐Liss, Inc.
Corrected TIMI frame count: Applicability in modern digital catheter laboratories when different frame acquisition rates are used
Authors: Vijayalakshmi Kunadian , Ashton Victoria J. , Wright Robert A. , Hall James A. , Stewart Michael J. , Davies Adrian , de Belder Mark A. 
Published: November 2004

AbstractThe original description of the TIMI frame count (TFC) method was based on angiograms acquired at 30 f/sec. Modern digital angiograms are acquired at lower frame rates (between 12.5 and 25 f/sec). Coronary angiography was acquired at 12.5 and 25 f/sec after 200 μg of intracoronary glyceryl trinitrate. Results of the corrected TIMI frame count (cTFC) at 12.5 and 25 f/sec for each vessel were: right coronary artery, 19.5 ± 5.2 and 20.4 ± 6.6 (P = 0.15); circumflex artery, 25.6 ± 8.2 and 25.9 ± 8.7 (P = 0.5); and left anterior descending artery, 22.5 ± 8.1 and 23.8 ± 10.4 (P = 0.15), respectively. The mean difference in the TFC between two injections by the same operator and by two operators was 0.4 (P = 0.7) and 0.4 (P = 0.2), respectively. The mean difference in the TFC for repeat measurements by the same observer and between two observers was 0.26 (P = 0.3) and 0.06 (P = 0.8), respectively. We confirm that the cTFC is a quantitative method to assess coronary flow that can be applied in a modern digital laboratory. Catheter Cardiovasc Interv 2004;63:426–432. © 2004 Wiley‐Liss, Inc.
Implantation of a second closure device in patients with residual shunt after percutaneous closure of patent foramen ovale
Authors: Schwerzmann Markus , Windecker Stephan , Wahl Andreas , Nedeltchev Krassen , Mattle Heinrich P. , Seiler Christian , Meier Bernhard 
Published: November 2004

AbstractPercutaneous closure of patent foramen ovale (PFO) in patients with presumed paradoxical embolism yields complete occlusion in > 90% of patients using contemporary closure devices. Patients with a residual shunt after percutaneous PFO closure have been found at increased risk for recurrent paradoxical events. Treatment options for such patients include medical treatment using antiplatelet drugs or oral anticoagulation, surgical device removal and patch closure, and percutaneous implantation of a second closure device. We report our experience with implantation of a second closure device in 10 patients with more than a minimal residual shunt ≤ 6 months after percutaneous PFO closure. Procedure and fluoroscopy times were similar for the initial and repeat intervention (32 vs. 30 min and 5 vs. 6 min, respectively; P = NS). There were no procedural complications during implantation of the second closure device. Follow‐up transesophageal echocardiography 6 months after the second percutaneous intervention revealed complete PFO closure in nine (90%) patients. Therefore, implantation of a second closure device in patients with persistence of more than a residual shunt after percutaneous PFO closure appears safe and effective. Catheter Cardiovasc Interv 2004;63:490–495. © 2004 Wiley‐Liss, Inc.
New method to increase a backup support of a 6 French guiding coronary catheter
Authors: Takahashi Saeko , Saito Shigeru , Tanaka Shinji , Miyashita Yusuke , Shiono Takaaki , Arai Fumio , Domae Hiroshi , Satake Shutaro , Itoh Takenari 
Published: November 2004

AbstractA 6 Fr guiding catheter is commonly used in the percutaneous coronary intervention (PCI). However, one of the limitations of the 6 Fr guiding catheter is its weak backup support compared to a 7 or an 8 Fr guiding catheter. In this article, we present a new system for PCI called the five‐in‐six system. Between March 2003 and September 2003, this system was tried on eight chronic total occlusion cases. The advantage of the five‐in‐six system is that it increases backup support of a 6 Fr guiding catheter. Catheter Cardiovasc Interv 2004;63:452‐456. © 2004 Wiley‐Liss, Inc.
New bifurcation stenting technique: Shunt stenting
Authors: Prasan Ananth M. , Pitney Mark R. , Ramsay David , Jepson Nigel S. , Friedman Daniel , Taylor David , Giles Robert W. 
Published: November 2004

AbstractThe optimal treatment of bifurcation lesions remains controversial. We describe a new technique we term shunt stenting. This technique incorporates both the new technology of drug‐eluting stents and a novel procedure for optimizing the ostial side branch stent positioning. To date, early angiographic and clinical follow‐up have been encouraging. Catheter Cardiovasc Interv 2004;63:474–481. © 2004 Wiley‐Liss, Inc.
Relief of pseudostenosis using the transit exchange catheter
Authors: Fortuin F. David , Sweeney John P. , Lee Richard W. 
Published: November 2004

AbstractPseudostenosis is a generally benign complication of percutaneous coronary intervention that is caused by the mechanical deformation of a tortuous artery by the guidewire. We describe two cases of a tortuous right coronary artery in which pseudostenosis was relieved by placing a Transit exchange catheter (Cordis) distally and subsequently removing the guidewire. This technique safely confirmed the diagnosis of pseudostenosis without losing guidewire position or requiring additional wires and balloons. Catheter Cardiovasc Interv 2004;63:457–461. © 2004 Wiley‐Liss, Inc.
Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children
Authors: Broniscer Alberto , Iacono Lisa , Chintagumpala Murali , Fouladi Maryam , Wallace Dana , Bowers Daniel C. , Stewart Clinton , Krasin Matthew J. , Gajjar Amar 
Published: November 2004

AbstractBACKGROUNDThe role of chemotherapy in the treatment of children with newly diagnosed diffuse brainstem glioma is uncertain. In the current study, the authors tested the efficacy of temozolomide treatment after radiotherapy (RT) in this setting.METHODSPatients ages 3–21 years were eligible for the current multiinstitutional study. An optional window therapy regimen consisting of 2 cycles of intravenous irinotecan (10 doses of 20 mg/m2 per day separated by 2 days of rest per cycle) was delivered over 6 weeks and was followed by conventionally fractionated RT. The 5‐day schedule of temozolomide (200 mg/m2 per day) was initiated 4 weeks after RT and was continued for a total of 6 cycles. The pharmacokinetics of temozolomide and its active metabolite, 5‐(3‐methyltriazen‐1‐yl)imidazole‐4‐carboxamide (MTIC), were analyzed during Cycles 1 and 3.RESULTSThirty‐three patients (median age at diagnosis, 6.4 years) were enrolled. Of the 16 patients who received window therapy, 6 had irinotecan treatment discontinued due to clinical progression (n = 5) or toxicity (n = 1); the remaining 10 experienced disease stabilization after 2 cycles. All patients completed RT (median dose, 55.8 gray). Twenty‐nine patients received a combined total of 125 cycles of temozolomide. Grade 3/4 neutropenia and thrombocytopenia occurred in 33% and 29% of all temozolomide cycles, respectively. In approximately one‐third of the cycles, dose reduction was required due to myelosuppression. No correlation was demonstrated between temozolomide/MTIC exposure and myelosuppression at the conclusion of Cycle 1. All patients died of disease progression (median survival, 12 months). The estimated 1‐year survival rate was 48% (standard error, 8%).CONCLUSIONSThe administration of temozolomide after RT did not alter the poor prognosis associated with newly diagnosed diffuse brainstem glioma in children. Cancer 2005. © 2004 American Cancer Society.
Solving the dilemma of the immunohistochemical and other methods used for scoring estrogen receptor and progesterone receptor in patients with invasive breast carcinoma
Authors: Fisher Edwin R. , Anderson Stewart , Dean Scott , Dabbs David , Fisher Bernard , Siderits Richard , Pritchard Jeffrey , Pereira Telma , Geyer Charles , Wolmark Norman 
Published: November 2004

AbstractBACKGROUNDThe authors attempted to resolve the dilemma posed by the lack of unanimity concerning the optimal immunohistochemical (IHC) method for determining and scoring estrogen receptor (ER) and progesterone receptor (PR).METHODSSections for IHC were prepared from paraffin embedded tumor samples from 402 patients with lymph node positive breast carcinoma who had biochemical receptor values (obtained with the dextran‐coated charcoal [DCC] method) and who were enrolled in a prospective, randomized trial (National Surgical Adjuvant Breast and Bowel Project protocol B‐09). IHC receptors were scored independently by two observers according to percent, intensity, and any‐or‐none algorithms. Results from these evaluations and from two computer‐assisted evaluations, DCC, and common pathologic characteristics were analyzed for optimum splits for positive reactions in univariate and multivariate analyses using a tree‐structured model. Concordance, sensitivity, and specificity were determined between the DCC method and all other methods.RESULTSInterobserver agreement and concordance between the DCC method and the other methods and among the methods were high. Univariate analyses revealed that a positive ER score obtained with all methods was related significantly to overall survival (OS) at 5 years and at 10 years. Results related to PR scores and disease‐free survival and recurrence‐free survival were less consistent. In multivariate analysis, it also was found that all methods for scoring ER predicted a better prognosis for OS in patients with an unfavorable lymph node status at 5 years and 10 years. Patients in a favorable lymph node status group were discriminated further by nuclear grade.CONCLUSIONSAll IHC methods for scoring ER appeared valid as prognostic indicators of OS in patients with positive lymph nodes. The any‐or‐none IHC method, by virtue of its simplicity, represents an appropriate choice for practical use. Cancer 2005. © 2004 American Cancer Society.
Trinuclear [NiFe] Clusters as Structural Models for [NiFe] Hydrogenase Active Sites
Authors: Sellmann Dieter , Lauderbach Frank , Heinemann Frank W. 
Published: November 2004

Abstract[Fe(CH3COCH=CHPh)(CO)3] reacts with [Ni(‘S4’)]x (x = 1, 2) or [Ni(‘S4C3Me2’)] [‘S4’2− = 1,2‐bis(2‐mercaptophenylthio)ethane(2‐),‘S4C3Me2’2− = 1,3‐bis(2‐mercaptophenylthio)‐2,2‐dimethylpropane(2‐)] to afford trinuclear [NiFe] clusters [Ni(‘S4’){Fe(CO)3}2] (1) and [Ni(‘S4C3Me2’){Fe(CO)3}2] (2) and the dinuclear FeIIFe0 complex [Fe(CO)(‘S4C3Me2’)Fe(CO)3] (3). Clusters 1 and 2 have Ni−Fe bond lengths similar to those of active or reduced states of [NiFe] hydrogenases, a sulfur‐dominated coordination sphere of Ni and iron‐bound CO. Therefore, 1 and 2 may serve as structural model complexes for the [NiFe] hydrogenase active site. Combination of the ‘S4C3Me2’ ligand with FeCl2·4H2O yielded [Fe(‘S4C3Me2’)]2 (4), the dinuclearity of which suggests that the ‘S4C3Me2’ ligand is less flexible than its ethylene‐bridged derivative, which affords a tetrameric [Fe(‘S4’)]4 complex reported earlier. Compound 4 reacts with 2 equiv. of CO to give [Fe(CO)(‘S4C3Me2’)]2 (5), which like 4 is only sparingly soluble in all common organic solvents. Complex 5 easily loses CO even if stored in the solid state. [Fe(CH3COCH=CHPh)(CO)3] reacts with 5 to afford 3 as the only product. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Towards the Design of Linear Homo‐Trinuclear Metal Complexes Based on a New Phenol‐Functionalised Diazamesocyclic Ligand: Structural Analysis and Magnetism
Authors: Du Miao , Zhao Xiao‐Jun , Guo Jian‐Hua , Bu Xian‐He , Ribas Joan 
Published: November 2004

AbstractThe formation of two novel phenoxo‐bridged linear trimetallic CuII and NiII complexes, [Cu3(μ‐L)2](CH3OH)2(ClO4)2 (1) and [Ni3(μ‐L)2(CH3OH)2](ClO4)2 (2), with a new diazamesocyclic ligand functionalised by additional phenol donor pendants (H2L = N,N′‐ bis(2‐hydroxybenzyl)‐1,4‐diazacycloheptane), has been achieved and both complexes have been characterised by IR spectroscopy, elemental analyses, conductivity measurements, thermal analyses and UV/Vis techniques. Single‐crystal X‐ray diffraction analyses revealed that both 1 and 2 have the similar phenoxo‐bridged linear trinuclear cores. For 1, two terminal and the central CuII ion are in square‐planar environments with the adjacent intramolecular Cu···Cu separation of 2.9376(9) Å. For 2, however, two terminal NiII ions are in square‐planar environments and the central NiII ion assumes an octahedral geometry by axial coordination of two methanol ligands, the adjacent intramolecular Ni···Ni distance being 3.007(3) Å. In both cases, the 1,4‐diazacycloheptane (DACH) ring adopts the normal boat configuration. The magnetic properties of complexes 1 and 2 have been investigated by variable‐temperature magnetic susceptibility measurements in the solid state. Complex 1 displays a very strong antiferromagnetic coupling interaction between the neighbouring μ‐phenoxo CuII centres with a J parameter of −314 cm−1 and the magneto‐structural correlation for such complexes is discussed in detail. For complex 2, the result indicates that both terminal NiII ions are diamagnetic and the central NiII shows typical paramagnetic behaviour. The presence of zero‐field splitting for NiII with a D parameter of 11 cm−1, being active at low temperature, is further corroborated by the magnetisation measurement at 2 K. Additionally, the interesting ESR spectra of 1 at different temperatures (from 298 K to 8 K) were investigated and interpreted. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Syntheses and Characterizations of Multidimensional Metal‐Organic Frameworks Based on Rings and 1D Chains
Authors: Li Xiaoju , Cao Rong , Sun Yanqiong , Bi Wenhua , Li Xing , Wang Yanqin 
Published: November 2004

AbstractFour novel multidimensional coordination polymers, {[Cd(3‐PYD)2(H2O)]·2H2O}n (1), [Pb(3‐PYD)2]n (2), {[Cu1.5(3‐PYD)3(H2O)]·1.5H2O}n (3) and [Zn(3‐PYD)2(H2O)2]n (4), have been hydrothermally synthesized from 3‐(3‐pyridyl)acrylic acid (3‐HPYD). In 1, 3‐PYD in a head‐to‐head arranged fashion bridges CdII, generating a two‐dimensional layer, which is further extended into a three‐dimensional supramolecular network by hydrogen‐bonding interactions. Compound 2 shows a two‐dimensional wave‐like layer that consists of {Pb(3‐PYD)}4 rings from head‐to‐tail arranged 3‐PYD. Compound 3 is a twofold interpenetrating three‐dimensional network consisting of {Cu(3‐PYD)}6 rings formed through the mixed head‐to‐head and head‐to‐tail arrangements of 3‐PYD. However, 4 is a three‐dimensional supramolecular framework constructed by one‐dimensional zinc‐3‐PYD chains through hydrogen‐bonding interactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Agallochaols A and B, Two New Diterpenes from the Chinese Mangrove Excoecaria agallochaL.
Authors: Wang Ji‐Dong , Guo Yue‐Wei 
Published: November 2004

AbstractTwo new ent‐isopimarane diterpenoids, agallochaols A (1) and B (2), were isolated from the dried stems and leaves of the mangrove Excoecaria agallocha L. Their structures were established on the basis of spectroscopic data and chemical evidence.
Rhodium(II)‐Catalyzed Inter‐ and Intramolecular Enantioselective Cyclopropanations with Alkyl‐Diazo(triorganylsilyl)acetates
Authors: Müller Paul , Lacrampe Fabienne 
Published: November 2004

AbstractThe intermolecular cyclopropanation of styrene with ethyl diazo(triethylsilyl)acetate (1a) proceeds at room temperature in the presence of chiral RhII carboxylate catalysts derived from imide‐protected amino acids and affords mixtures of trans‐ and cis‐cyclopropane derivatives 2a in up to 72% yield but with modest enantioselectivities (<54%) (Scheme 1 and Table 1). Protiodesilylation of a diastereoisomer mixture 2a with Bu4NF is accompanied by epimerization at C(1) (→3). The intramolecular cyclopropanation of allyl diazo(triethylsilyl)acetate (8a), in turn, affords optically active 3‐oxabicyclo[3.1.0]hexan‐2‐one (9a) with yields of up to 85% and 56% ee (Scheme 3 and Table 2). Similarly, the (2Z)‐pent‐2‐enyl derivative 8d reacts to 9d in up to 77% yield and 38% ee (Scheme 3 and Table 3). In contrast, the diazo decomposition of (2E)‐3‐phenylprop‐2‐enyl and 2‐methylprop‐2‐en‐1‐yl diazo(triethyl‐silyl)acetates (8b and 8c, resp.) is unsatisfactory and gives very poor yields of substituted 3‐oxabicyclo[3.1.0]hexan‐2‐ones 9b and 9c, respectively (Table 3).
Isolation and Characterization of New Bitter Diterpenoids from the Basidiomycete Sarcodon scabrosus
Authors: Ma Bing‐Ji , Zhu Hua‐Jie , Liu Ji‐Kai 
Published: November 2004

AbstractThe novel cyathane‐type diterpenoids scabronine G and H (1 and 2, resp.) were isolated from the fruiting bodies of the basidiomycete Sarcodon scabrosus together with four known compounds, allocyathin B2 (3), sarcodonin A (4), sarcodonin G (5), and scabronine F (6). Their structures were determined by spectroscopic means, including 2D‐NMR (HMBC, HMQC, ROESY, 1H,1H‐COSY).
Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki‐67 nuclear antigen, and p53 during 2‐acetylaminofluorene‐induced rat liver preneoplasia
Authors: Chakraborty Tridib , Samanta Shaonly , Ghosh Balaram , Thirumoorthy N. , Chatterjee Malay 
Published: November 2004

AbstractOur previous studies have shown that vanadium, a dietary micronutrient, has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. In this study, we evaluated the role of vanadium on some potential protein expression markers of carcinogenesis, such as metallothionein (MT), an intracellular metal‐binding protein linked with cell proliferation and apoptosis, Ki‐67 nuclear antigen, and p53 tumor suppressor during 2‐acetylaminofluorene (2‐AAF)‐induced (0.05% in basal diet) rat liver preneoplasia. In a short‐term regimen, supplementation of vanadium at a dose of 0.5 ppm effectively suppressed the formation of DNA ‘comets’ (29.55%; P < 0.02), thereby indicating its nongenotoxicity at this particular dose. Vanadium administration throughout the study reduced relative liver weight (RLW), nodular incidence (57.15%), total number, and multiplicity (48.45%) with restoration of hepatic zinc (Zn), magnesium (Mg), selenium (Se), copper (Cu), iron (Fe), and calcium (Ca) contents when compared to the carcinogen control. Moreover, treatment with vanadium significantly abated the expressions of MT and Ki‐67, studied at four sequential time points. An increased immunopositivity of p53 protein (1.03 ± 0.23%; P < 0.02) was found in vanadium‐treated rat liver with an elevated apoptotic‐labeling index (AI; P < 0.001) as documented by TUNEL assay. Furthermore, a positive correlation between MT expression and Ki‐67 labeling along with a strong negative correlation between MT immunoreactivity and AI (r = −0.9000, P = 0.0004 at week 24) at various time intervals suggest that, vanadium‐mediated suppression of MT and Ki‐67 expressions may be associated with induction of apoptosis. The results thus provide evidence for the first time in support of the potential role of vanadium on induction of p53 and apoptosis with concurrent suppression of MT and Ki‐67 in order to have an understanding, in part, of the chemopreventive mechanism of this trace element in limiting neoplastic transformation in a defined model of experimental rat hepatocarcinogenesis. © 2004 Wiley‐Liss, Inc.