bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Lithium Intrusion‐Blocking Interfacial Shield for Wide‐Pressure‐Range Solid‐State Lithium Metal Batteries
Authors: Hu Xia , Yu Jiahao , Wang Yao , Guo Weiqian , Zhang Xiang , Armand Michel , Kang Feiyu , Wang Guoxiu , Zhou Dong , Li Baohua 
Published: October 2023

AbstractLithium garnets are considered as promising solid‐state electrolytes for next‐generation solid‐state Li metal batteries (SSLBs). However, the Li intrusion driven by external stack pressure triggers premature of Li metal batteries. Herein, for the first time, an in situ constructed interfacial shield is reported to efficiently inhibit the pressure‐induced Li intrusion in SSLBs. Theoretical modeling and experimental investigations reveal that high‐hardness metallic Mo nanocrystals inside the shield effectively suppress Li dendrite growth without alloy hardening‐derived interfacial contact deterioration. Meanwhile the electrically insulated Li2S as a shield component considerably promotes interfacial wettability and hinders Li dendrite penetration into the bulk of garnet electrolyte. Interfacial shield‐protected Li6.4La3Zr1.4Ta0.6O12 (LLZTO)‐based cells exhibit significantly enhanced cyclability without short circuits under conventional pressures of ≈0.2 MPa and even at high pressure of up to 70 MPa; which is the highest endurable stack pressure reported for SSLBs using garnet electrolytes. These key findings are expected to promote the wide‐pressure‐range applications of SSLBs.
Targeting DNA Damage and Repair Machinery via Delivering WEE1 Inhibitor and Platinum (IV) Prodrugs to Stimulate STING Pathway for Maximizing Chemo‐Immunotherapy in Bladder Cancer
Authors: Wang Wenkuan , Yang Feiya , Zhang Lingpu , Wang Mingshuai , Yin Lu , Dong Xiying , Xiao Haihua , Xing Nianzeng 
Published: October 2023

AbstractBoth cisplatin‐based chemotherapy and immune checkpoint blockers (ICBs)‐based immunotherapy are the first‐line treatments for patients with advanced bladder cancer. Cancer cells can develop resistance to cisplatin through extensive DNA repair, while a low response rate to ICBs is mostly due to the presence of an immunosuppressive microenvironment and low PD‐L1 expression. Herein, a glutathione (GSH)‐responsive nanoparticle (NP2) loaded with cisplatin prodrug (Pt (IV)) and WEE1 inhibitor (MK1775) is designed. NP2 can be triggered by GSH in cancer cells, and the released MK1775 can inhibit the activity of WEE1 protein, which ultimately increases DNA damage by cisplatin. Genome‐wide RNA sequencing first reveals that NP2 can inhibit DNA repair machinery by interfering with the cell cycle and significantly activate the stimulator of interferon genes pathway. Tumor growth is significantly inhibited by NP2 in vivo. As innate and adaptive immune responses are stimulated, the immunosuppressive microenvironment is modified, and the “immune cold tumor” is transformed into an “immune hot tumor". In addition, NP2 can upregulate PD‐L1 expression in tumor cells, thereby increasing the response rate of PD‐L1 monoclonal antibody (αPD‐L1) and eliciting long‐term immune responses in both primary and metastatic tumors.
A Promising Optical Bio‐Interface: Graded‐Index Hydrogel Fiber
Authors: Zhuo Xuan , Han Yaning , Bian Yinxu , Xu Anni , Shen Hua 
Published: October 2023

AbstractLight in human‐machine interactions requires a bio‐friendly, efficient, and stable optical bio‐interface. Optical hydrogel fibers (HFs) with excellent biocompatibility will advance next‐generation implantable optical bio‐interfaces. However, the efficiency of HFs is limited by high optical attenuation. Moreover, the stability of implanted HFs is degraded by refraction leakage due to contact with high‐refractive‐index (RI) tissue and bending losses due to in vivo motion or organ micro‐stress. Here, a graded‐index hydrogel fiber (GIHF) is created for high‐performance, anti‐interference optical bio‐interface. The gradient RI of GIHF provides a “self‐focusing” ability to confine the light field, achieving a high transmittance and resistance to stress bending and interference of high‐RI tissue. Additionally, GIHF with optimized RI distribution is fabricated by a projection‐suspended photocuring (PSP) 3D printing method. The optical loss (0.25 dB cm−1), tissue‐contact transmittance (98%), and bending loss (0.24 dB per 90°) of the developed GIHF indicate that it outperforms other HFs. The GIHF optical bio‐interface is used to guide sufficient light to excite fluorescence in phantom brain, and the fluorescence signal is stable under multi‐frequency vibration. It paves the way for advances in optogenetics and brain‐machine interfaces (BMI).
Development of a Hibernation‐Inspired Preservation Strategy to Enhance the Clinical Translation of Photosynthetic Biomaterials
Authors: Corrales‐Orovio Rocío , Castillo Valentina , Rozas Pablo , Schenck Thilo L. , Egaña José Tomás 
Published: October 2023

AbstractPhotosynthetic biomaterials have emerged as a promising approach for delivering oxygen and other bioactive molecules in several biomedical applications. This technology is based on the use of standard biomaterials loaded with photosynthetic cells for the controlled release of oxygen at the target site. However, as well as for other cell‐based approaches, a main drawback for their clinical translation is the low shelf‐life of living materials. Here, the potential of inducing a dormant hibernation‐inspired state to preserve photosynthetic biomaterials for clinical applications is explored. First, a protocol to preserve microalgae Chlamydomonas reinhardtii is optimized and then applied to photosynthetic scaffolds, showing that the viability and functionality of the biomaterial is preserved for up to 6 weeks. To evaluate the clinical viability of this approach, both fresh and preserved photosynthetic scaffolds are implanted in a full‐skin defect mouse model. The safety of this approach is evaluated and confirmed by several means, including clinical parameters, histological assays, and local and systemic molecular analysis. Altogether, for the first time the successful preservation of photosynthetic biomaterials through a hibernation‐inspired strategy is described here, which could have a tremendous impact for the clinical translation of these materials as well as other photosynthetic therapies.
Deciphering the Functional Long Non‐Coding RNAs Derived from MicroRNA Loci
Authors: Li Weiqian , Huo Yue , Ren Yue , Han Chenxi , Li Shuo , Wang Kangning , He Manman , Chen Yiying , Wang Yanran , Xu Lingjie , Guo Yuehong , Si Yanmin , Gao Yufeng , Xu Jiayue , Wang Xiaoshuang , Ma Yanni , Yu Jia , Wang Fang 
Published: October 2023

AbstractAlbeit the majority of eukaryotic genomes can be pervasively transcribed to a diverse population of lncRNAs and various subtypes of lncRNA are discovered. However, the genome‐wide study of miRNA‐derived lncRNAs is still lacking. Here, it is reported that over 800 miRNA gene‐originated lncRNAs (molncRNAs) are generated from miRNA loci. One of them, molnc‐301b from miR‐301b and miR‐130b, functions as an “RNA decoy” to facilitate dissociation of the chromatin remodeling protein SMARCA5 from chromatin and thereby sequester transcription and mRNA translation. Specifically, molnc‐301b attenuates erythropoiesis by mitigating the transcription of erythropoietic and translation‐associated genes, such as GATA1 and FOS. In addition, a useful and powerful CRISPR screen platform to characterize the biological functions of molncRNAs at large‐scale and single‐cell levels is established and 29 functional molncRNAs in hematopoietic cells are identified. Collectively, the focus is on miRNA‐derived lncRNAs, deciphering their landscape during normal hematopoiesis, and comprehensively evaluating their potential roles.
Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction
Authors: Zhang Zheng , Zhu Hongyuan , Zhao Guoqing , Miao Yunyi , Zhao Lingzhu , Feng Jinteng , Zhang Huan , Miao Run , Sun Lin , Gao Bin , Zhang Wencheng , Wang Zheng , Zhang Jianfang , Zhang Ying , Guo Hui , Xu Feng , Lu Tian Jian , Genin Guy M. , Lin Min 
Published: October 2023

AbstractDynamically evolving adhesions between cells and extracellular matrix (ECM) transmit time‐varying signals that control cytoskeletal dynamics and cell fate. Dynamic cell adhesion and ECM stiffness regulate cellular mechanosensing cooperatively, but it has not previously been possible to characterize their individual effects because of challenges with controlling these factors independently. Therefore, a DNA‐driven molecular system is developed wherein the integrin‐binding ligand RGD can be reversibly presented and removed to achieve cyclic cell attachment/detachment on substrates of defined stiffness. Using this culture system, it is discovered that cyclic adhesion accelerates F‐actin kinetics and nuclear mechanosensing in human mesenchymal stem cells (hMSCs), with the result that hysteresis can completely change how hMSCs transduce ECM stiffness. Results are dramatically different from well‐known results for mechanotransduction on static substrates, but are consistent with a mathematical model of F‐actin fragments retaining structure following loss of integrin ligation and participating in subsequent repolymerization. These findings suggest that cyclic integrin‐mediated adhesion alters the mechanosensing of ECM stiffness by hMSCs through transient, hysteretic memory that is stored in F‐actin.
Fully Integrated Ultrathin Solid Immersion Grating Microspectrometer for Handheld Visible and Near‐Infrared Spectroscopic Applications
Authors: Park Jung‐Woo , Jeon Jaehun , Kim Gi Beom , Jeong Ki‐Hun 
Published: October 2023

AbstractDespite advances in microfabrication, compact spectrometers still face challenges in shrinking their size without sacrificing optical performance. Here, the solid immersion grating microspectrometer (SIG‐µSPEC) for high spectral resolution in a broad operational wavelength range is reported. The spectroscopic module incorporates a silicon microslit, index‐matched lens, plane mirrors, solid immersion grating (SIG), and a CMOS line sensor within a small form factor. The SIG facilitates high angular dispersion of light on a planar focal plane, resulting in an average spectral resolution of 5.8 nm, with over 76% maximum sensitivity from 400 to 800 nm. SIG‐µSPEC measures the spectral reflectance of fruits at different ripening stages, clearly revealing changes in the chlorophyll absorption band. The measured spectrum is further utilized for the precise prediction of the soluble solid content (SSC) levels, achieving a high correlation (R2 = 0.91) and a ratio of prediction‐to‐deviation of 2.36. This compact microspectrometer holds the potential for precise and non‐invasive spectral analysis across point‐of‐care fields.
Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa
Authors: Jiang Nan , Sewell Taylor B. , Kowalski Theresa L. , Rekab Aisha , Hills Susannah , Fazlollahi Ladan , Lauren Christine T. , Morel Kimberly , Mehta Lakshmi , Liao Jun 
Published: October 2023

AbstractWe report a novel homozygous 49.6 kb deletion of chromosome 18q12.1 involving the last exon of DSG3 in dizygotic twins with phenotype consistent with acantholytic blistering of the oral and laryngeal mucosa (ABOLM). The twin siblings presented predominantly with friability of the laryngeal and respiratory mucosa. This is only the second report in the literature of this unusual autosomal recessive blistering disorder. The diagnosis explains the mucosal phenotype of a pemphigus‐like disorder without evidence of autoimmune dysfunction. The exclusion of an autoimmune basis has management implications. The deletion also involved the DSG2 gene, which is associated with arrhythmogenic right ventricular dysplasia (ARVD). The affected siblings and heterozygous parents do not show any cardiac phenotype at this time. Functional studies would further clarify how deletions resulting in loss of function of DSG3 may cause the reported phenotypes of DSG3‐related ABOLM.
Palladium Encapsulated by an Oxygen‐Saturated TiO2 Overlayer for Low‐Temperature SO2‐Tolerant Catalysis during CO Oxidation
Authors: Chen Jingkun , Su Yuetan , Meng Qingjie , Qian Hehe , Shi Le , Darr Jawwad A. , Wu Zhongbiao , Weng Xiaole 
Published: October 2023

AbstractThe development of oxidation catalysts that are resistant to sulfur poisoning is crucial for extending the lifespan of catalysts in real‐working conditions. Herein, we describe the design and synthesis of oxide‐metal interaction (OMI) catalyst under oxidative atmospheres. By using organic coated TiO2, an oxide/metal inverse catalyst with non‐classical oxygen‐saturated TiO2 overlayers were obtained at relatively low temperature. These catalysts were found to incorporate ultra‐small Pd metal and support particles with exceptional reactivity and stability for CO oxidation (under 21 vol % O2 and 10 vol % H2O). In particular, the core (Pd)‐shell (TiO2) structured OMI catalyst exhibited excellent resistance to SO2 poisoning, yielding robust CO oxidation performance at 120 °C for 240 h (at 100 ppm SO2 and 10 vol % H2O). The stability of this new OMI catalyst was explained through density functional theory (DFT) calculations that interfacial oxygen atoms at Pd−O−Ti sites (of oxygen‐saturated overlayers) serve as non‐metal active sites for low‐temperature CO oxidation, and change the SO2 adsorption from metal(d)‐to‐SO2(π*) back‐bonding to much weaker σ(Ti−S) bonding.
CycloSiFA: The Next Generation of Silicon‐Based Fluoride Acceptors for Positron Emission Tomography (PET)
Authors: Mawick Matthias , Jaworski Carolin , Bittermann Jens , Iovkova Ljuba , Pu Yinglan , Wängler Carmen , Wängler Björn , Jurkschat Klaus , Krause Norbert , Schirrmacher Ralf 
Published: October 2023

AbstractThe ring‐opening Si‐fluorination of a variety of azasilole derivatives cyclo‐1‐(iPr2Si)−4‐X−C6H3−2‐CH2NR (4: R=2,6‐iPr2C6H3, X=H; 4 a: R=2,4,6‐Me3C6H2, X=H; 9: R=2,6‐iPr2C6H3, X=tBuMe2SiO; 10: R=2,6‐iPr2C6H3, X=OH; 13: R=2,6‐iPr2C6H3, X=HCCCH2O; 22: R=2,6‐iPr2C6H3, X=tBuMe2SiCH2O) with different 19F‐fluoride sources was studied, optimized and the experience gained was used in a translational approach to create a straightforward 18F‐labelling protocol for the azasilole derivatives [18F]6 and [18F]14. The latter constitutes a potential clickable CycloSiFA prosthetic group which might be used in PET tracer development using Cu‐catalysed triazole formation. Based on our findings, CycloSiFA has the potential to become a new entry into non‐canonical labelling methodologies for radioactive PET tracer development.
Effect of sintering on processability vis‐a‐vis microcellular foaming of ultrahigh molecular weight polyethylene
Authors: Shandilya Prashant Mani , Ghosh Anup K. 
Published: October 2023

AbstractProcessing of ultrahigh molecular weight polyethylene (UHMWPE) involves sintering due to its high melt strength and no flowability above melting temperature. Variations in compression molding pressure during sintering lead to chain rearrangement at the sintered interphase and the boundary, affecting foamability. UHMWPE particles are sintered using compression molding; samples are prepared at two different pressures: UHPE‐HP (80 bar) and UHPE‐LP (40 bar) at 180°C. The sintering phenomenon of UHMWPE particles is observed through an optical microscope, and their effect on foaming was observed. UHPE‐HP foams are systematically studied to obtain the foaming window. Increasing foaming pressure (80–120 bar) made UHPE‐HP foams softer (0.350–0.219 g/cm3) with varying average cell size (26.37–46.1 μm) and foam cell density (3.98 × 107–1.06 × 108 cells/cm3), and compression modulus decreased from 9 to 5.4 MPa. DMA results showed a strong dependence of stiffness on crystallinity, and foamed samples exhibit higher stiffness than their unfoamed counterpart. The storage modulus for foamed samples decreases with increase in the gas content. The UHPE‐LP foam is relatively softer, with a lower foam density (0.233 g/cm3), a higher expansion ratio, bigger average foam cells (35.13 μm), and lower foam cell density (9.33 × 107 cells/cm3). This is due to constrained crystallinity at the interphase and pre‐existing cavities, favoring the foaming.
Synthesis, polymerization and thermal properties of bio‐based benzoxazine resins containing imide or amide functionality
Authors: Chen Qian , Ren Dayong , Sheng Weichen , Zhang Kan 
Published: October 2023

AbstractTwo novel bio‐based benzoxazine monomers containing imide or amide group (HPIDD‐fa and HPBA‐fa) were synthesized from raw materials of benzoyl chloride/phthalic anhydride, tyramine, furfurylamine and paraformaldehyde via a two‐step reaction. Fourier transform infrared spectroscopy (FT‐IR), proton and carbon nuclear magnetic resonance (NMR) spectroscopies were performed to characterize the structures of the benzoxazine monomers. The curing behavior was investigated by using differential scanning calorimetry (DSC) and in situ FT‐IR, and the DSC results indicate that the peak curing temperatures of HPIDD‐fa and HPBA‐fa are centered at 248.5 and 230.1°C, respectively. In addition, thermogravimetric analysis (TGA) suggests that the newly developed bio‐based benzoxazine‐derived polybenzoxazines present excellent thermal stability with Td10 (temperature at 10% weight loss) of 385 and 368°C for poly(HPIDD‐fa) and poly(HPBA‐fa), respectively. The current investigation suggests that our newly obtained bio‐based thermosetting resins are promising materials for high‐tech applications.
Janus POSS‐based hydrogel electrolytes with highly stretchable and low‐temperature resistant performances for all‐in‐one supercapacitors
Authors: Fan Kaiqi , Liu Sen , Feng Wenbo , Yang Wentong , Peng Jiwei , Liu Ruixue , Fang Shaoming , Zhang Xiaojing 
Published: October 2023

AbstractConductive hydrogels can be utilized in the field of flexible supercapacitors due to their stretchable properties and high ionic conductivity. However, many of the conductive hydrogels lose their stretchability and conductivity at subzero temperatures. Herein, a novel Janus POSS‐based hydrogel electrolyte that shows excellent flexibility and ionic conductivity at low temperatures is designed and prepared by the copolymerization of acrylamide and a water‐soluble Janus‐type polyhedral oligomeric silsesquioxane (AS‐POSS) containing sodium sulfonate groups and double bonding groups. The sodium sulfonate groups of AS‐POSS and LiCl endow the hydrogel electrolyte with excellent anti‐freezing ability. Simultaneously, the double bonding groups of AS‐POSS enable a successful POSS crosslinking in the polymer network, resulting in a highly stretchable hydrogel electrolyte (1445%) with high ionic conductivity (0.067 S cm−1) at −20°C. Thereafter, the all‐in‐one flexible supercapacitor is prepared by in‐situ polymerization of aniline. Based on the exceptional anti‐freezing properties of the Janus POSS‐based hydrogel electrolyte, the all‐in‐one supercapacitor exhibits stable electrochemical performance (>90% capacitance retained under deformation at −20°C) and excellent cycling stability (only 19.7% capacitance decay over 2000 charge/discharge cycles at −20°C) at low temperatures. The Janus POSS‐based hydrogel electrolyte is expected to be a promising gel electrolyte for an all‐in‐one supercapacitor that resists freezing.
Meßmethoden der Polarisationsspannungen. III
Authors: Piontelli R. , Bertocci U. , Bianchi G. , Guerci C. , Poli G. 
Published: October 2023

AbstractEs werden die verschiedenen Methoden zur Messung von Polarisationsspannungen an Hand der allgemein üblichen Apparaturen besprochen sowie deren Stromspeisungs‐ und Registriereinrichtungen. Es wurde die Überlegenheit der direkten Methode festgestellt. Die Stromspeisung erfolgt mit Rechteckimpulsen. Der sich während einer Impulslänge ergebende Spannungsverlauf an der Elektrode wird hierbei mit einem Kathodenstrahloszillographen verfolgt.Es wird eine Polarisationszelle mit zur Elektrode frontal ansetzender Sonde mit seitlicher Öffnung beschrieben; die Rührung des Elektrolyten erfolgte durch Umlauf desselben. Ferner wird eine Apparatur zur Erzeugung von Rechteckimpulsen und zur Messung der Polarisationsspannung beschrieben, die in diesem Laboratorium entwickelt und erfolgreich angewandt wurde und die den obengenannten Bedingungen genügt.Es werden einige Oszillogramme gezeigt, die mit dieser Apparatur erhalten wurden und aus denen Vorzüge und Grenzen der Leistung der Anlage hervorgehen.
Feste Gashydrate. V Die Bindungsenergien
Authors: v. Stackelberg M. 
Published: October 2023

AbstractEs äßt sich zeigen, daß die einfachen Gas‐ und Flüssigkeitshydrate insofern ideale Käfigverbindungen sind, als zwischen den Hydratbildnermolekeln M und den Wassermolekeln der diese einschließenden Hohlraum‐wände nur van der Waalssche Kräfte wirksam werden. Die Bildungswärmen der Gas‐und Flüssigkeitshydrate sind dementsprechend gleich den Verfestigungswärmen ihrer Komponenten. Das Fehlen spezifischer chemischer Bindungskräfte macht eine Berechnung der Tension der Hydrate aus der Siedetemperatur des Hydratbildners möglich. Zudem ergibt diese Berechnung in Übereinstimmung mit der Erfahrung, daß nurStoffe mit Siedetemperaturen unter 60° C Hydrate des hier behandelten Typs bilden können. Im Gegensatz zu diesen Verhältnissen bei den einfachen Gashydraten tritt bei den H2S‐Doppelhydraten eine zusätzliche spezifische Bindungsenergie von bis zu 20 kcal je Mol M · 2H2S · 17H2O auf. Die Natur dieser zusätzlichen Energie ist noch unklar.Die stabilisierende Wirkung der „Hilfsgase”︁ bei Mischhydraten ist von anderer Art, aber ebenfalls noch nicht befriedigend deutbar.
Die Gefrierpunktserniedrigung geschmolzener Elektrolyte bei Zusatz fremder Salze II. Mitteilung: Der Molekularzustand von geschmolzenem LiSO4
Authors: Kordes Ernst , Ziegler Günther , Proeger Hans‐Jürgen 
Published: October 2023

AbstractAus der Lage des Eutektikums in den binären Systemen von Li2SO2 mit SrSO4, BaSO4 bzw, PbSO4, aus der Gefrierpunktserniedrigung von Li2SO4 durch kleine Zusätze von Sulfaten anderer Metalle und aus der Gefrierpunktserniedrigung von KNO3 durch kleine Zusätze von Li2SO4 wird auf folgende Dissoziations‐verhältnisse von Li2SO4 in Elektrolytschmelzen geschlossen:magnified imageDurch Überführungsmessungen wird das Vorhandensein von Li‐ und SO4‐haltigen komplexen Anionen und Kationen im geschmolzenen reinen Li2SO4 bestätigt.
Beiträge zur Elektrochemie des Niobs 1. Die Reduktion aus salzsauren Lösungen
Authors: Cozzi D. , Vivarelli S. 
Published: October 2023

AbstractDie Reduktion salzsaurer Lösungen von Nb(V) wird auf polarographischem Wege an einer Quecksilberkathode mit großer Oberfläche verfolgt. Es wird nachgewiesen, daß bei der Reduktion in salzsaurer Lösung Nb (IV) gebildet wird, das in Nb (V) und Nb(III) disproportioniert. Die Reduktion kommt mit der Bildung von Nb (III) zum Abschluß. In Anwesenheit von Äthylenglykol, bei Konzentrationen von 10 bis 20 Vol.‐%, verläuft die Disproportionierung langsamer. Auch unter diesen Bedingungen führt die Reduktion zu Nb (IV), das jedoch weiter zu Nb (II) reduziert werden kann. Infolge der Einwirkung von Nb (IV) auf Nb (II) endet die Reduktion (auch in Anwesenheit von Glykol) mit der Bildung von Nb (III). Weiter wurde das Normalpotential von Nb(V)/Nb(IV) mit und ohne Glykolzusatz gemessen.