bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Follow‐Up Evaluation of the Menninger Pilot Migraine Study Using Thermal Training
Authors: Solbach Patricia , Sargent Joseph D. 
Published: June 2005

SYNOPSISOne hundred and ten headache sufferers entered the Migraine Headache Study from 1969 to 1974; 74 completed 270 days of training and follow‐up; 36 (33%) had thermal training, but dropped out before completing 270 days.Records were examined for all participants with 23 variables identified. A progress report was obtained through questionnaire andor telephone survey from 56 (76%) of the 74 “graduates” and from 12 (33%) of the 36 “dropouts” through telephone survey alone.Comparisons were made between respondents and nonrespondents in the Graduate and Dropout groups. Although there is reduction of headache frequency for both groups, Graduates show a greater decrease in headache intensity and duration, take fewer medications and practice more routinely and more often than Dropouts.
Preventive Treatment of Migraine with Mini‐Doses of Danitracene
Authors: Sulman F. G. , Pfeifer Y. , Superstine E. 
Published: June 2005

SYNOPSISDanitracene is an oral antamine preparation; with three effects: anti‐serotoninic, anti‐histaminic and anti‐depressive. Its lack of unpleasant side effects permits its long use for the preventive treatment of migraine. Its chemical structure‐ring, C‐beta, C‐alpha, amine‐allows specific blockade of receptors for serotonin and histamine geared to the same configuration. Danitracene preventive treatment with 1‐3 x 0.5‐1 mgday for a period of 1‐3‐6 months can almost completely eliminate migraine attacks. Fifty out of 75 patients profited from treatment of 1‐3 x 0.5 mgday showing a drop from 5‐30 attacks per month to 0‐1 attacks per month. During this period 50 cases with high urinary excretion of serotonin, 5‐HIAA or histamine were normalized and relieved of their migraine attacks. Starting with very low doses at night overcomes the sedative anti‐serotonin effect, improves results and avoids dropouts. Two side‐effects typical for anti‐serotonin drugs were observed: sedation or dizziness and hyperorexia. The hypnotic effect tended to disappear after protracted treatment with one 0.5 mg doseday only. The hyperoraexia, however could only be overcome by reduced dosage. Randomization, “double‐blind” and cross‐over design were used in the trial.
Muscle Contraction and Migraine Headache: Psychophysiologic Comparison
Authors: Bakal Donald A. , Kaganov Judith A. 
Published: June 2005

SYNOPSISMuscle contraction headache and migraine patients were compared for symptoms of muscular and vascular activity, and responsiveness to frontalis electromyogram (EMG) biofeedback therapy. Locations of head pain were non‐specific to the diagnostic groups. Migraine patients had higher frontalis EMG activity than muscle contraction headache patients and headache‐free controls. Both headache groups had higher neck EMG activity than controls. Pulse velocities in the superficial temporal arteries were similar in the two headache patient groups but different from controls. It is suggested that muscle contraction headache and migraine patients have similar physiologic predisposition for headaches. Further support for similar predisposition in the two groups was provided by the frontalis EMG biofeedback results which showed this treatment to be equally effective for both groups.
Fluphenazine for Tension Headache; Double‐Blind Study
Authors: Hakkarainen Heikki 
Published: June 2005

SYNOPSISFluphenazine, a fluorinated piperazine derivative of phenothiazine was compared with placebo in a double‐blind study of 50 patients with tension headache. Daily dose of fluphenazine was 1 mg. The trial was completed by 48 patients. Treatment periods were 2 months each.Days with headache diminished significantly more during treatment with fluphenazine than placebo (P < 0.001). Duration ot the headache decreased and severity of pain was reduced significantly with fluphenazine. Mean quantities of analgesics used during one headache day was 1.6 on fluphenazine and 2.5 on placebo (P < 0.001). Thirty‐six patients considered fluphenazine and one placebo as the superior drug.Side effects were reported by 19 patients on fluphenazine and 15 on placebo. Two patients interrupted fluphenazine trial because of extrapyramidal dyskinesias.
Hemicrania and Ipsilateral Trunk and Limb Symptoms
Authors: Summers David S. 
Published: June 2005

SYNOPSISOne hundred and eleven cases of migraine seen over 412 years were studied. A useful diagnostic feature was motor or sensory symptoms ipsilateral to hemicrania. It is suggested that this lateralization is inherent in the response of the sympathetic nervous system to a generalized body reaction, but the response is predominantly peripheral and confined to adrenoceptive components unilaterally. This hypothesis should be tested by assessing the frequency of ipsilateral symptoms in common and classic migraine, and by neuropharmacologic tests.
Metabolic Changes During the Prodrome of a Migraine Headache
Authors: Benson Herbert , Greenwood Martha M. 
Published: June 2005

SUMMARYThe continuous measurement of oxygen consumption, carbon dioxide elimination and heart rate were serendipitously recorded during the prodrome of a migraine headache. Mean oxygen consumption and carbon dioxide elimination decreased by 17% and 35%, respectively. Paradoxically, heart rate increased by 41% during the prodrome. It is not known whether these physiologic changes are primary or secondary to the prodrome of the migraine headache.
Differential EMG Activity in Subjects with Muscle Contraction Headaches Related to Mental Effort
Authors: Boxtel A. van , van der Ven J. Roozeveld 
Published: June 2005

SYNOPSISEMG activity of two groups of subjects was compared: seven subjects with frequent muscle contraction headaches, associated with mental effort, and eleven subjects without headaches. The EMG activity of frontalis, temporalis, trapezius muscles and forearm flexors was studied at rest (baseline) and during a mental task. Only the frontalis EMG activity differentiated reliably between the two groups, both at rest and during task.
Plasma Tryptophan in Migraine
Authors: Salmon S. , Fanciullacci M. , Bonciani M. , Sicuteri F. 
Published: June 2005

SYNOPSISFree and total plasma tryptophan (TRY) was evaluated in migraine and daily headache sufferers. In migraineurs, free plasma TRY was significantly higher on the day of the attack, the day preceding and subsequent to the attack in comparison with controls.The possibility that in migraineurs a lowering of brain 5‐HT may displace TRY from its binding to plasma albumin through an unknown feedback mechanism is suggested. In daily headache sufferers total plasma TRY levels were statistically significantly lower compared with controls. This may reflect a deficiency of 5‐HT in the brain.
Skin Temperature Biofeedback and Migraine
Authors: Mullinix Janice M. , Norton Barbara J. , Hack Stanley , Fishman Marvin A. 
Published: June 2005

SYNOPSISSkin temperature biofeedback was used in treating two groups of patients with migraine. The experimental group received true auditory feedback controlled by increases in skin temperature of their fingers, while the control group received a similar “positive” signal independent of skin temperature changes and controlled by the investigator. The true feedback group increased their skin temperature significantly more (p < 0.05) than the control group, but both groups showed similar improvement in headaches. This study suggests that biofeedback techniques are useful in treating patients with migraine, and the mechanism, presumably a placebo effect, is independent of peripheral skin temperature changes.
Headache in Patients with Hypertension
Authors: Traube Y. M. , Korczyn A. D. 
Published: June 2005

SYNOPSISThe relationship between high blood pressure and headache (HA) was assessed retrospectively among 241 patients attending a hypertension clinic. HA was common (45.6%), particularly among women (68%). Patients with systolic blood pressure higher than 170 mmHg andor diastolic blood pressure higher than 110 mmHg had nocturnal andor early morning HA more often. Fifty‐four subjects became HA free during antihypertensive therapy. Their blood pressure (BP) decrease was significantly greater than the BP fall of those whose HA did not disappear with treatment. Nocturnal and early morning HA may be a symptom of hypertension in subjects with markedly elevated BP, and control of BP may be beneficial in some hypertensive patients.
A Controlled Study of the Effect of Oral Contraceptives on Migraine
Authors: Ryan Robert E. 
Published: June 2005

SYNOPSISHeadache frequency and index in migraine patients both on and off oral contraceptives were observed.Twenty patients received an oral contraceptive for two months while another twenty patients did not. After two months the second group received the oral contraceptive, and the first did not. Increased frequency of headaches, and headache index most prominent in cases of moderate severity, occurred while the patients were on the pill. Three distinct groups of patients were identified. One group improved while on the pill; a second group had headaches and a third group showed no influence of oral contraceptives on headache.
The Dopaminergic and Noradrenergic Blockades:
Authors: Lechin Fuad , van Der Dijs Bertha , Lechin Ernesto , Peña Francisco , Bentolila Ana 
Published: June 2005

SYNOPSISIn accordance with a double‐blind pilot study carried out in 60 headache patients, it was found that dopaminergic blockage was able to maintain the improvement induced by d‐amphetamine plus propranolol (AP)‐treatment as well as to relieve significantly those patients not improved by the amphetaminic treatment. The addition of noradrenergic blockade provoked the total disappearance of the improvement in some (including those relieved by AP‐treatment), whereas it induced a significant further increment of the relief in other patients. These results suggest that there are two kinds of headache patients, those improved by the enhancement and those improved by the blockade of the noradrenergic system. The demonstrated fact that the dopaminergic blockade was able to relieve both types of headaches indicates that a common factor, located at the dopamine‐system level, is shared by the pathophysiologic mechanisms of both types ot headaches.
Migraine Prophylaxis with Lisuride Hydrogen Maleate‐A Double Blind Study of Lisuride Versus Placebo
Authors: Somerville Brian W. , Herrmann Werner M. 
Published: June 2005

SYNOPSISThis paper reports the results of a double‐blind clinical trial of the antiserotonin compound Lisuride hydrogen maleate (LHM) in the prophylaxis of frequent and severe migraine. The study was conducted over a minimum period of three months. When judged according to reduction in frequency of attacks, LHM emerged significantly superior to placebo (p<0.05), though a higher rate of side effects was noted in the active treatment group. A high rate of placebo response (in keeping with other similar trials) was observed.It is concluded that LHM is significantly superior to placebo as a migraine prophylactic and its relative freedom from serious side effects suggests a useful role for the drug as an alternative to methysergide.
Physical Characteristics and Allergic History In Young Men with Migraine and Other Headaches
Authors: Schéle Rickard , Ahlborg Björn , Ekbom Karl 
Published: June 2005

SYNOPSISPhysical characteristics and allergic history have been studied in 436 men 18 years of age with migraine and non‐migrainous headache (NMH) and compared to those of controls. Body height was on average 11 and 8 mm less in the migraine and NMH groups than in the controls (p<0.02 and p<0.05 respectively). Isometric muscle strength in knee extension was on average 4% less among the migraine subjects than among the controls (p<0.01). The average strength of the NMH subjects was for all three muscle tests significantly below that of the controls (p<0.05). Physical working capacity measured on a bicycle ergometer was lower for both migraine and NMH subjects as compared to the controls (p<0.001). Body weight and femoral condylar breadth did not differ significantly between the groups, nor did mean values for hematocrit, sedimentation rate, resting blood pressure, or the results from tests of visual acuity, color vision or hearing capacity. It can be concluded that unselected young men with migraine and NMH are significantly shorter and have lower muscle strength and physical working capacity than controls, although the differences are small. The small group of subjects with cluster headache tended to be taller and heavier and to have higher physical working capacity and lower blood pressure than subjects with migraine and NMH. Allergy to food was more frequently reported by migraineurs than by subjects with non‐migrainous headache (p<0.01) or without headache (p<0.01). Allergy to pollens as well as asthma were present in about the same proportions in all groups (p>0.80).
Headache in a Hospitalized Military Population
Authors: Packard Russell C. , Brannon William 
Published: June 2005

SYNOPSISThe problem of headache is ubiquitous in the medical profession, and is a very frequent complaint at military sick calls. In 1969 a retrospective study of 196 patients hospitalized at the Philadelphia Naval Hospital offered the opinion that “all patients had symptoms and signs of vascular headaches of the migraine type.”Our study was done in a prospective manner to analyze the headache syndromes of 100 patients requiring admission to the Neurology Service at the National Naval Medical Center, Bethesda, Maryland. Only 33% of cases could be classified as vascular headache of the migraine type in this study, utilizing the criteria proposed by the Ad Hoc Committee on Classification of Headache. The other types varied considerably. Findings related to age, sex, circumstances of admission, expectations of hospitalization, history of headache in a primary relative, head trauma, neurologic examination, and laboratory studies are discussed.
The Five Hour Glucose Tolerance Test and Effect of Low Sucrose Diet in Migraine
Authors: Dexter James D. , Roberts John , Byer John A. 
Published: June 2005

SYNOPSISSeventy‐four patients were evaluated who suffered from migraine and associated their attacks to the mid‐morning or mid‐afternoon fasting state. These seventy‐four patients underwent a standard five hour, 100 gram glucose tolerance test. The glucose tolerance curves of six of the patients were classified diabetic and fifty‐six patients exhibited a curve consistent with degrees of reactive hypoglycemia, i.e., serum glucose of less than 65 mg% or a drop of 75 mg% within one hour. Following dietary therapy with a low sucrose, six meal regimen, all patients who demonstrated a diabetic glucose tolerance curve showed an improvement of greater than 75%, and three have been headache free. Of the fifty‐six patients who showed reactive hypoglycemia curves, forty‐three returned for follow‐up after dietary instruction. Of those forty‐three patients 27, (63%) showed greater than 75% improvement, 17 (40%) showed 50 to 75% improvement and 4 (9%) showed 25 to 50% improvement.
Toxic Effects of Ergotamine Used for Migraine
Authors: Hokkanen E. , Waltimo O. , Kallanranta T. 
Published: June 2005

SYNOPSISForty‐three patients (6 males and 37 females) who had used ergotamine tartrate 10 mg or more per week continuously over six months were studied. Twenty (47%) of the patients had symptoms and signs compatible with ergotism. This group had not used more ergotamine tartrate than the group, free of symptoms. Of the patients with symptoms, 13 had cardiovascular symptoms and 5 had clinical signs of peripheral neuropathy. Forty‐three per cent of the patients examined had a normal electroencephalogram and the remainder relatively slight abnormalities. Eight patients had signs of peripheral neuropathy in their electroneuromyographic examination., The neurophthalmological examinations were all normal. Eighteen of 23 patients examined psychologically and psychiatrically were characterized as neurotic. Concomitant diseases were more often seen in the group with symptoms of ergotism; it is especially notable that all patients with collagen or diabetic disorders belonged to this group.
Chronic Paroxysmal Hemicrania: A Case Report
Authors: Russell D. , Christoffersen B. , Hörven I. 
Published: June 2005

SYNOPSISCorneal indentation pulse amplitudes and intraocular pressures were obtained from a 51‐year‐old Danish woman‐diagnosed as having chronic paroxysmal hemicrania. During headache attacks, values for both procedures were found to be markedly increased, especially on the symptomatic side. Complete relief of symptoms was obtained by indomethacin, prophylactically.
Psychophysiological Studies of Headache: Is There Similarity Between Migraine and Muscle Contraction Headaches?
Authors: Cohen Michael J. 
Published: June 2005

SYNOPSISTypically migraine and muscle contraction headaches are thought to be different disorders. Recently some investigators have argued that these headache categories are quantitatively, but not qualitatively distinct. Studies of vasomotor and electromyographic (EMG) reflexes and treatments for these headaches were reviewed to elucidate similarities and differences. Similarities include for both types of headaches high levels of tension in the muscles of the head and neck, a vasoconstrictive component, a responsiveness to treatment by relaxation or reduction of frontalis muscle tension. Differences between migraine and muscle contraction headaches relate to the status of the temporal artery between and during headaches and the standard medical treatments used for each. Systematic research is needed to establish if fundamental differences exist between these two major categories of headache.
Is Volitional Manipulation of Hemodynamics a Valid Rationale for Biofeedback Therapy of Migraine?
Authors: Sovak M. , Kunzel M. , Sternbach R.A. , Dalessio D.J. 
Published: June 2005

SYNOPSISResponses of supraorbital (SA), superficial temporal (TA), and digital (F) arterial beds and the heart rate were studied in 5 normal subjects and 10 migraineurs, when their hand temperature was increased by volition and/or by heat. In normal subjects, volitional digital arterial dilation coincided with vasoconstriction in SA and TA. In migraineurs the response varied. Bradycardia resulted in most subjects except in unimproved migraineurs. Heat induced hand vasodilation led to dilation in SA and TA and to tachycardia. In those 8 migraineurs who improved clinically the finger temperature feedback training apparently did not result in conditioning of a single autonomic response (i.e. digital vasodilation), but in a general decrease of the sympathetic tonic outflow.
Skin Temperature Self‐Regulation and Non‐Invasive Regional Cerebral Blood Flow
Authors: Largen John W. , Mathew Roy J. , Dobbins Ken , Meyer John S. , Claghorn James L. 
Published: June 2005

SYNOPSISTheoretical notions concerning the mechanism of migraine alleviation via “hand‐warming” techniques remain unclear and are somewhat hampered by a lack of knowledge as to what effect skin temperature self‐regulation has on intracerebral blood flow. Twelve normal female subjects were trained either to increase or to decrease the skin temperature of their hands. Following extensive training, subjects were given one measure of non‐invasive regional cerebral blood flow (rCBF) during a relaxation run and another measure while self‐regulating their skin temperature. The skin temperatures of the hand‐warming and hand‐cooling groups changed in significantly opposite directions. However the rCBF of either the left or right hemispheres showed no such concomitant differentiation. The present study contributes physiological confirmation of existing clinical indications that skin temperature manipulation per se may not be the major factor responsible for the therapeutic gains seen in migraine therapy.
Peripheral Temperatures of Migraineurs Undergoing Relaxation Training
Authors: Werbach Melvyn R. , Sandweiss Jack H. 
Published: June 2005

SYNOPSISForty‐five migraine patients entered a program of biofeedback‐assisted relaxation training. Their mean finger temperature prior to training was found to be significantly lower than that of patients with either non‐migrainous headaches, tinnitus or hypertension. Furthermore, while the other three patient groups warmed their hands several degrees during the first session, the migraine patients were unable to do so.Of the thirty‐seven patients who completed ten training sessions, twenty‐seven were rated as improved. A significant inverse correlation was found between the ability to warm hands during the first session and treatment success. Although patients that improved showed increased hand temperatures across training sessions, the gain scores were not significant. Age was the second best predictor of outcome with the youngest patients showing the most improvement.
Psychological Correlates of Frontalis EMG and Pain in Tension Headache
Authors: Harper Robert G. , Steger Jeffery C. 
Published: June 2005

SYNOPSISFrontalis EMG, headache pain ratings, and psychological measures of personality and physical‐emotional symptom complaints were obtained from female tension headache patients. Whereas there was no relationship between EMG and headache pain measures, personality factors were significantly associated with patient pain ratings. Physical‐emotional symptom complaints were significantly related to frontalis EMG, consistent with the notion of a psychological component to tension headache.
Prednisone Therapy for Cluster Headache
Authors: Couch James R. , Ziegler Dewey K. 
Published: June 2005

SYNOPSISPrednisone in peak doses of 10‐80 mg/day was employed for therapy in 19 patients with cluster headache. Overall, 14 of the 19 patients (73%) had greater than 50% relief and 11 (58%) had 100% relief from headache. The remaining 5 patients had less than 50% improvement. Of the subjects who were greater than 50% improved, 12 received peak doses of prednisone of 40 mg. or more, one received 30 mg. and one received 10 mg. The subjects with less than 50% improvement received peak prednisone doses of 10, 30, 40, 60 and 80 mg. Recurrence of cluster headache was noted in 79% of patients when the prednisone dose was tapered below 10–20 mg./d. Prednisone appears effective in relief of cluster headache but recurrence can be expected as the dose is reduced.
Divascan(r) in Migraine Prophylaxis. Open Trial with Three Different Doses
Authors: Osterman P.O. 
Published: June 2005

SYNOPSISIn an open trial 26 patients with severe migraine were treated with 3 different doses of Divascan (1‐isopropyl‐noradrenochrome‐5‐monosemicarbazone) ‐ 15, 30 and 40 mg a day. During treatment with Divascan there was a significant reduction in the number of migraine attacks and in the headache index compared with a preceding control period. The prophylactic effect of 30 and 40 mg Divascan a day seemed better than that of 15 mg a day. The headache frequency was significantly lower with 40 mg a day than with 15 mg a day. A good or very good effect of the treatment was reported by 24 per cent of the patients on 15 mg a day, by 48 per cent on 30 mg a day and by 57 per cent on 40 mg a day. No serious side‐effects were noted. Divascan seems to be a promising drug in the prophylactic treatment of migraine but further studies are needed to establish what doses are optimal in migraine prophylaxis.