bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hegel und der anthropologische Kontinuitätsskeptizismus
Authors: Peters Julia 
Published: October 2023

Abstract
According to so-called transformative theories of rationality, human nature is of a fundamentally different kind than the nature of non-human animals, because it is transformed by the possession of rational capacities. This is assumed tobe reflected in the fact that human nature and non-human nature require two fundamentally different forms of explanation: reason-based explanations on the one hand, explanations with reference to natural laws on the other. There is no continuity between these two forms of explanation, i.e. a transition from one to the other is not intelligible. In this paper, I will draw on Hegel to sketch a counter-position to this kind of “continuity skepticism” (Dorit Bar-On, 2013). The central thesis is that Hegel’s project in his anthropology is to make the transition from one order of explanation to another intelligible by outlining an intermediate realm in which the phenomena under investigation are no longer entirely outside, and not yet entirely inside, the rational order of explanation.
Negativität des Geistes
Authors: Sickenberger Isabel 
Published: October 2023

Abstract
Drawing on Hegel’s anthropology, this paper reconstructs ‘madness’ as an essential stage in the formation of the subject by developing the dialectical character of madness. This goes along with resituating the negativity of spirit as arising on an intermediary stage between nature and developed spirit as second nature. Hegel determines the freedom of spirit as “absolute negativity”. Madness shows a moment of radical negativity that is not viable as such. The formation of subjectivity is thus threatened by that which makes it possible. The art of spirit is to over-come this form of abstract negativity, though not to lose the radicality of negativity, but to deepen it. ‘Absolute negativity’ is Hegel’s term for this successful sublation and simultaneous deepening of negativity.
Two Ways of Looking at Theory, Exemplified by The Dynamics of Bureaucracy by Peter M. Blau
Authors: Swedberg Richard 
Published: October 2023

Abstract
In this paper two different approaches to social theory are presented, and then illustrated through an in-depth analysis of one study, The Dynamics of Bureaucracy (1955) by Peter M. Blau. The first of these two ideal types focuses on theory as a text, say Suicide by Durkheim or some journal article (theory as a text). According to this viewpoint, which is the conventional one, theory is seen as embodied and finalized in a text, not so different from a literary text. According to the second approach, which is more in the spirit of theorizing, theory is instead seen as a set of interconnected activities (theory as activities). According to this perspective, theory means to engage in a number of activities besides reading: you do research, including work with theoretical issues; you then try to formulate and write down a final version of the theory in an article or a book. A theory is always part of a large set of activities. The paper ends with a comparison of the two perspectives as well as an attempt to see what Blau’s work can add to our understanding of theory as a practical and creative enterprise.
Technology use and clinical outcomes in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes
Authors: Baboun Daniela , Solano Natalia , Del Toro Victoria , Alvarez-Salvat Rose , Granados Andrea , Carrillo-Iregui Adriana 
Published: October 2023

Abstract

Objectives
Technology use has been shown to improve diabetes control, but minority youths tend to have low rates of technology use and exhibit suboptimal glycemic control. We examined the impact of continuous glucose monitors (CGM) and continuous subcutaneous insulin infusion (CSII) on glycemic control in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes (T1D).

Methods
A cross-sectional study was conducted among 140 pediatric T1D patients seen at a multidisciplinary clinic. From January to November 2022, data on demographics and glycated hemoglobin (HbA1c) levels were collected. Patients were categorized as technology (CGM, CSII, or both) or non-technology users (finger stick meter (FS) and multiple daily injections (MDI)).

Results
The majority identified as Hispanic (79 %) and had public health insurance (71 %). Sixty-nine percent used technology. Compared with non-technology users, technology users had significantly lower mean HbA1c levels (9.60 vs. 8.40 %, respectively) (p=0.0024), though no group (CGM + CSII, CGM + MDI, FS + CSII, and FS + MDI) achieved a mean HbA1c level of <7.0 %. Regarding minority status, no significant differences in mean HbA1c levels existed between Hispanics and Blacks in the CGM + MDI and FS + CSII groups (p=0.2232 and p=0.9224, respectively). However, there was a significant difference in mean HbA1c levels between Hispanic and Black non-technology users (9.19 vs. 11.26 %, respectively) (p=0.0385).

Conclusions
Technology users demonstrated better glycemic control than non-technology users. Further research is needed to investigate factors affecting glycemic control in minority youths with T1D.
Effects of gender on fetal cortical development: a secondary analysis of a prospective cross-sectional study
Authors: Mappa Ilenia , Marra Maria Chiara , Pietrolucci Maria Elena , Lu Jia Li Angela , Di Mascio Daniele , D’Antonio Francesco , Rizzo Giuseppe 
Published: October 2023

Abstract

Objectives
The primary objective was to evaluate the effects of fetal sex on fetal cortical development in low-risk pregnancies. Secondary objective was the evaluate the impact of gestational age.

Methods
This was a secondary analysis of a prospective cross-sectional study on low-risk fetuses undergoing fetal neurosonography between 19 and 34 weeks of gestation. The depth of Sylvian Fissure (SF), Parieto Occipital Fissure (POF) and Calcarine Fissure (CF) were evaluated and related to fetal sex. Neurosonographic variables were normalized for fetal head circumference and expressed as multiple of the median (MoM).

Results
A total of 344 fetuses were considered (173 male, 171 female). The baseline characteristic of the two groups were similar except a higher birthweight present in male fetuses (p=0.044). The depth SF (p=0.023) CF (p=0.014) and POF (p=0.046) showed significantly higher values in male fetuses when all the gestational age range was considered. However, when data were controlled for gestational age, these differences resulted significant only after 28 weeks.

Conclusions
Differences in cortical development related to gender occur after 28 weeks of gestation with an increase depth of SF, POF and CF in male fetuses.
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes
Authors: Aizawa Eishi , Ozonov Evgeniy A , Kawamura Yumiko K , Dumeau Charles‐Etienne , Nagaoka So , Kitajima Tomoya S , Saitou Mitinori , Peters Antoine HFM , Wutz Anton 
Published: October 2023

AbstractRecent studies have reported the differentiation of pluripotent cells into oocytes in vitro. However, the developmental competence of in vitro‐generated oocytes remains low. Here, we perform a comprehensive comparison of mouse germ cell development in vitro over all culture steps versus in vivo with the goal to understand mechanisms underlying poor oocyte quality. We show that the in vitro differentiation of primordial germ cells to growing oocytes and subsequent follicle growth is critical for competence for preimplantation development. Systematic transcriptome analysis of single oocytes that were subjected to different culture steps identifies genes that are normally upregulated during oocyte growth to be susceptible for misregulation during in vitro oogenesis. Many misregulated genes are Polycomb targets. Deregulation of Polycomb repression is therefore a key cause and the earliest defect known in in vitro oocyte differentiation. Conversely, structurally normal in vitro‐derived oocytes fail at zygotic genome activation and show abnormal acquisition of 5‐hydroxymethylcytosine on maternal chromosomes. Our data identify epigenetic regulation at an early stage of oogenesis limiting developmental competence and suggest opportunities for future improvements.
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration
Authors: Liang Peigang , Zhang Jiaqi , Wu Yuchen , Zheng Shanyuan , Xu Zhaopeng , Yang Shuo , Wang Jinfang , Ma Suibin , Xiao Li , Hu Tianhui , Jiang Wenxue , Huang Chaoqun , Xing Qiong , Kundu Mondira , Wang Bo 
Published: October 2023

AbstractThe remodeling and stiffening of the extracellular matrix (ECM) is a well‐recognized modulator of breast cancer progression. How changes in the mechanical properties of the ECM are converted into biochemical signals that direct tumor cell migration and metastasis remain poorly characterized. Here, we describe a new role for the autophagy‐inducing serine/threonine kinases ULK1 and ULK2 in mechanotransduction. We show that ULK1/2 activity inhibits the assembly of actin stress fibers and focal adhesions (FAs) and as a consequence impedes cell contraction and migration, independent of its role in autophagy. Mechanistically, we identify PXN/paxillin, a key component of the mechanotransducing machinery, as a direct binding partner and substrate of ULK1/2. ULK‐mediated phosphorylation of PXN at S32 and S119 weakens homotypic interactions and liquid–liquid phase separation of PXN, impairing FA assembly, which in turn alters the mechanical properties of breast cancer cells and their response to mechanical stimuli. ULK1/2 and the well‐characterized PXN regulator, FAK/Src, have opposing functions on mechanotransduction and compete for phosphorylation of adjacent serine and tyrosine residues. Taken together, our study reveals ULK1/2 as important regulator of PXN‐dependent mechanotransduction.
The Impact of Standardized Recovery Pathways on Language Barriers and Inpatient Pain Management
Authors: Segal Kathryn R. , Gomez Jaime A. , Schulz Jacob F. , Alvandi Leila Mehraban , Fornari Eric D. 
Published: October 2023

BACKGROUND AND OBJECTIVES
Inpatient postoperative care is reliant upon clear, open communication between providers and patient–families, and thus is particularly vulnerable to disparities when discordant languages exist. It is not yet understood how standardized postoperative protocols may mitigate disparities related to language discordance.

METHODS
This is a retrospective cohort study among adolescent idiopathic scoliosis patients who underwent posterior spinal fusion at a tertiary care children’s hospital in Bronx, New York after implementation of a postoperative pathway in 2017. Outcomes reliant upon communication between patient–families and providers were measured, including measures of pain management (number and type of pain medications requested, daily pain assessments, total opioids consumed), as well as outpatient pain scores.

RESULTS
A total of 160 patients were included (39 language other than English [LOE]). Between patient cohorts, there were no significant differences in demographic or operative characteristics. On univariate analyses, LOE patients were more likely to be given a basal dosing of patient-controlled analgesia or additional boluses (26% vs 12%, P = .03), consumed 0.53 fewer benzodiazepine medications per day (P = .01), and were more likely to have pain at outpatient follow-up (67% vs 43%, P = .03). On multivariate analyses, LOE patients were more likely to be placed on basally dosed or receive additional boluses of patient-controlled analgesia (odds ratio 3.19, 95% confidence interval 1.15–8.85).

CONCLUSIONS
As standardized pathways become more common in health care, it is critical to monitor for components of these protocols that may be vulnerable to language-related disparities, such as therapies reliant on symptom description and outpatient follow-up.
Ritka lokalizációjú plasmocytoma autológ hemopoetikus őssejtátültetést követően
Authors: Virga István , Páyer Edit , Barna Sándor , Bedekovics Judit , Váróczy László , Virga Bálint , Nagy Zsolt , Illés Árpád , Magyari Ferenc 
Published: October 2023

BevezetésA plasmasejtes myeloma érett B-sejtes neoplasia, amit klonális plasmasejt szaporulat jellemez. A diagnóziskor az esetek mindössze 4%-át teszi ki az extramedulláris plasmocytoma (EMP), mely a betegség előrehaladásával, relapsusok alkalmával gyakrabban, már 3–14%-ban mutatható ki.Esetismertetés50 éves nőnél 2019-ben indult kivizsgálás fogyás, gyengeség, fulladás miatt. A laborvizsgálatok során anaemia, hypercalcaemia, beszűkült vesefunkció volt kiemelhető. 2019 márciusában végzett perifériás vér- és csontvelővizsgálat alapján plasmasejtes leukemia volt igazolható, diffúz csontvelői érintettséggel, 1q21 amplifikációval, hyperdiploid kromoszóma állománnyal. A nagy rizikójú betegség miatt 4 ciklus VTD-PACE (bortezomib, thalidomid, dexamethason, cisplatin, doxorubicin, cyclophosphamid, etoposid) indukciós kezelés hatására MRD negatív komplett remisszió alakult ki. Sikeres őssejtgyűjtést követően további 2 ciklus VTD-kezelést kapott. Bendamustin-melphalan kondicionáló kezelést követően végeztük el az autológ őssejt-transzplantációt. A 100 napos posttranszplantációs vizsgálatok során MRD negatív komplett remisszió volt véleményezhető. 22 havi fenntartó lenalidomid kezelést követően mindkét alsó végtagon tapintható szövetszaporulat jelentkezett. A csontvelő áramlási citometriás vizsgálata negatív volt. 18FDG-PET/CT és kontrasztos MR-vizsgálatok az alapbetegség relapsusát valószínűsítették. Klinikánkon elvégzett core biopszia szövettani vizsgálata izom érintettséggel járó multiplex extramedulláris plasmocytomát igazolt. 2. vonalbeli kezelésként DRD (daratumumab, lenalidomid, dexamethason) terápia indult, azonban nem megfelelő terápiás válasz miatt KPD (carfilzomib, pomalidomid, dexamethason) protokollal folytattuk. KPD-kezelés mellett jó terápiás választ követően ismételt progresszió igazolódott. Emiatt lokális irradiáció történt, mely mellett kiterjedt, szisztémás relapsus jelent meg. EDAP (etoposid, cisplatin, citarabin, dexamethason) protokoll szerinti mentő kezelés indult venetoclax kiegészítésben. Mivel a beteg klinikailag jól reagált, allogén őssejt-transzplantáció elbírálására felterjesztés történt, melyet elfogadtak.MegbeszélésA plasmasejtes myelomában viszonylag gyakoriak a másodlagos, izommal határos szöveti beszűrődések, azonban a közvetlen izomszövetben megjelenő plasmocytomák igen ritkák. Esetünket a biopsziával és képalkotó vizsgálatokkal igazolt ritka EMP-lokalizáció miatt tartottuk bemutatásra alkalmasnak.
Exploring the efficacy of Shexiang Tongxin extract pills in severe heart failure
Authors: Zeng Yanping , Ma Weixing , Xue Hua , Ren Xiaohui , Zhu Guanfeng , Xiao Keming , Jiang Zhenhua 
Published: October 2023

The clinical efficacy of Shexiang Tongxin pills (STP) on cardiac function, inflammation, and prognosis was investigated in patients with severe heart failure. A total of 140 patients with severe heart failure, diagnosed and treated at the Shaoxing Central Hospital and its affiliates, were divided into control and experimental groups. Patients in the control group received conventional treatment, while those in the experimental group were given STP plus conventional treatment. The cardiac functions, levels of inflammatory factors, and outcomes of 6-minute walk distance (6MWD) were assessed and compared after 12 weeks of intervention. Besides, the rehospitalization and mortality proportions were also determined during a 1-year follow-up. In addition, oxygen-glucose deprivation and reperfusion (OGD/R) were conducted to mimic the injury of H9c2 cells in heart failure; cell survival, cytotoxicity, apoptosis, and inflammatory factors were also evaluated. Post-intervention, patients in the experiment group demonstrated greater improvement in cardiac functions, especially regarding left ventricular end-diastolic diameter and N-terminal pro-B-type natriuretic peptide, which were significantly decreased, while left ventricular ejection fraction was significantly increased (P < 0.05). Further, the levels of inflammatory factors, including tumor necrosis factor-α, hypersensitive C-reactive-protein, and interleukin 6, were significantly lower (P < 0.05), and a superior 6MWD outcome was observed in patients from the experimental group, compared to the control group (P < 0.05). After 1-year follow-up, both rehospitalization rate and mortality were significantly decreased in the experimental group, compared to the control group (rehospitalization, 38.57% vs. 55.71%, and mortality, 12.86% vs. 27.14%, respectively; P < 0.05). Furthermore, STP increased cell survival and reduced cell apoptosis, cytotoxicity, and inflammatory response in cardiomyocytes induced by OGD/R. Shexiang Tongxin pill demonstrated significant and promising clinical effects in treating severe heart failure by ameliorating cardiac functions, reducing inflammatory factor levels, and improving patients’ prognosis. In addition, STP ameliorated cellular damage and inflammation at cellular level. Thus, STP demonstrated important clinical values.
The Relationship Between Smartphone Addiction and Neck Pain Prevalence among Older Population: A Cross Sectional Study
Authors: Amarnath Kanna , Janakiraman Balamurugan , Shah Jeni Shailesh 
Published: October 2023

Introduction: After pandemics of covid 19, world interaction has been more through social media and through virtual. With lots of benefit of the technology, there is a pitfall of this also. Because of this, usage of smart phone has increased so addiction of it occurs even in elderly population. Due to their posture of using smart phone, and its addiction, there may be chances of having additional neck pain and disabilities. So, here is the need to see whether their smart phone addiction has any role in their neck pain prevalence.
Methodology: The study examined 90 elderly population from Ahmedabad by random table sampling, in the age group of 60-70 years. Participants were asked to fill a Performa with the questionnaires of smart phone addiction scale (SAS) and neck disability index (NDI). Level of significant was kept at 5%. Spearman correlation coefficient was used to correlate between both SAS and NDI.
Result: From 90 participants, there was 36 females and 54 males. Mean±SD of SAS and NDI was 107.8±22.5 and 7.4±4.99 respectively. Spearman correlation coefficient showed a significant Moderate positive correlation between SAS and NDI (r=0.649, p<0.001).
Conclusion: The study showed the positive correlation between smartphone addiction and musculoskeletal problems in neck in elderly population.
Pore-Scale Characterization of CO2 Trapping and Oil Displacement in Three-Phase Flow in a Heterogeneous Layered Sandstone
Authors: Li Yingwen , Yang Yongfei , Dong Mingzhe , Imani Gloire , Yao Jun , Zhang Kai , Sun Hai , Zhong Junjie , Zhang Lei 
Published: October 2023

Summary
Permeability variation in the vertical direction, a typical sandstone reservoir heterogeneity, can trap a large amount of oil in the low-permeability layer. We performed water-alternating-gas (WAG) injection and CO2 foam flooding on a specially constructed millimeter-sized layered sandstone and investigated fluid distribution using high-resolution X-ray microtomography. Based on the segmented images, CO2 capillary-trapping capacity, oil recovery, Euler number, shaper factor, capillary pressure, and fluid flow conductivity were calculated. Our results show that increasing the number of WAG cycles favored CO2 capillary trapping, and oil recovery was enhanced by the WAG strategy. However, there was still a significant amount of oil trapped in the low-permeability layer. After the WAG injection, the connectivity of the residual oil clusters decreased, the capillary pressure of the oil clusters increased, and oil flow conductivity decreased. This was not conducive to further oil recovery. The subsequent injection of CO2 foam effectively recovered the oil in the low-permeability layer. During the no-injection period, we observed a crossflow phenomenon caused by gravity segregation (the high-permeability layer was located below the low-permeability layer), i.e., oil in the low-permeability layer decreased while oil in the high-permeability layer increased, which is beneficial for subsequent oil production. Furthermore, CO2 moved upward driven by gravity, and although capillary barriers could prevent CO2 from escaping, subsequent water injection was essential to improve the stability of CO2 capillary trapping. This work accurately quantifies the distribution of oil and gas in high- and low-permeability layers, thus providing fundamental data for oil recovery and CO2 trapping in reservoirs with vertical heterogeneity. Although the sample used in the experiment was not natural reservoir rock, our results imply that when the permeability ratio between the two layers is greater than 2, sufficient attention must be paid to the fluid distribution differences caused by this layered heterogeneity. Different displacement strategies, such as WAG and CO2 foam flooding, or gravity differences between oil and gas can be used to enhance oil recovery.
Lymphatic drainage of sinonasal malignancies and the role of sentinel node biopsies
Authors: Kashani Fatemeh , Weiss Bernhard G , Bartenstein Peter , Canis Martin , Haubner Frank 
Published: October 2023

Abstract
Background: Locoregional recurrence is a critical factor in the prognosis of sinonasal malignancies. Due to the rarity of these tumours, as well as the heterogeneity of histologies and anatomical subsites, there is little evidence regarding the rate and location of regional metastases in sinonasal malignancies. Elective regional lymph node dissection in the therapy of sinonasal malignancies has become controversial. On the one hand, elective regional lymph node dissection is considered to be an overtreatment in the cN0 cases. On the other hand, undetected occult lymphatic metastases are associated with a poor prognosis. In this study, we discuss the role of lymph node scintigraphy as a minimally invasive procedure in the treatment of sinonasal malignancies based on our two years of practical experience and the currently available data.
Results: This is a descriptive, monocentric, retrospective study, including 20 cases of cN0 malignant sinonasal neoplasm, that underwent a surgical therapy between 2020 and 2022. The following aspects were investigated: tumour entity, localisation of the primary tumour, tumoral stage, localisation of the sentinel lymph nodes, and postoperative complications. Squamous cell carcinoma was the most frequently diagnosed tumour entity (50%), followed by adenocarcinoma (20%) and malignant melanoma (15%), adenoid cystic carcinoma and mucoepidermoid carcinoma. Sentinel lymph nodes were most frequently found in the ipsilateral neck region I (45%), followed by the ipsilateral neck region II (40%). In all cases, the removed lymph nodes were free of malignancy. There were no postoperative complications due to lymph node biopsy. There were no recurrences during the study period.
Conclusion: Sentinel node biopsy adds more safety to the management of cN0 sinonasal malignancies due to its low morbidity. Elective neck dissection can be avoided in these cases.