bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Heat Island and Electrical Load Estimation Using Machine Learning in Metropolitan Area of Rio de Janeiro
Authors: França Gutemberg Borges , de Almeida Vinícius Albuquerque , de Lucena Andrews José , Peres Leonardo de Faria , Velho Haroldo Fraga de Campos , de Almeida Manoel Valdonel , Pimentel Gilberto Gomes , Cardozo Karine do Nascimento , Belém Liz Barreto Coelho , de Miranda Vitor Fonseca Vieira Vasconcelos , Ferreira Leonardo de Brito , Maciel Álvaro de Souza Andrade , Santos Fillipi Archetti dos 
Published: October 2023

Abstract

We developed a daily electrical load forecasting model for the State of Rio de Janeiro and a monthly model for each Light concessionaire substation in the Metropolitan Area of Rio de Janeiro (MARJ). The data used are 1) daily National System Operator (ONS) electrical load data respecting to State of Rio de Janeiro for four years (2017–2020); 2) the monthly electrical load of 84 Light substations for 11 years (2010–2020); 3) the maximum, minimum, and mean air temperature. In addition, remotely sensed land-surface temperature (LST) based on Landsat data from 1984 to 2020 is used to restructure the current meteorological network on MARJ based on the disposition of the Light substations. Using cross-validation, we performed 500 daily and 500 monthly training-testing experiments of five regressive machine learning-based algorithms. Results for daily-ONS and monthly-Light loads show average correlations (hindcast in parentheses) of the fitted models of 0.85 ± 0.09 (0.83 ± 0.07) and 0.89 ± 0.05 (0 .91 ± 0.06), respectively. The model's Mean Average of Error (MAE) values correspond to a percentage error of about 4.03% (daily) and 4.83% (monthly). According to the monthly electrical load behavior revealed, when the temperature changes from 23 to 26℃ at MARJ, it rises roughly from 1.92x10⁶ ± 67227.4 kWh to 2.70x10⁶ ± 90198.5 kWh. We performed a cluster analysis based on the locations of 1) the 18 meteorological stations currently installed, 2) the 84 Light electrical load substations, and 3) the urban heat island cores. Results reveal seven locations where new meteorological stations should be installed to model the electrical load with higher spatial resolution in MARJ.
Using a dual metabolomics strategy to investigate the mechanism of intragastric local pancreatic hypothermia in rats with acute pancreatitis
Authors: Yu Fang , Tang Zhanhong , Li Xiang , Zhang Xingwen , Tan Zheng , Chen Yun , Liu Xinyu , Liu Lilei 
Published: October 2023

Abstract
Background
Acute pancreatitis (AP) is an inflammatory disease that causes pancreatic autodigestion, and severe AP (SAP) is associated with high morbidity and mortality. Thus, a rapid approach that reverses harmful symptoms when patients with AP arrive at the emergency room is required.
Methods
We investigated the effect and mechanism of intragastric hypothermia on AP using a dual metabolomics strategy to detect metabolites and metabolic pathways. ELISA and immunohistochemistry with western blotting were used to measure serum amylase levels and cytokine expression, respectively, in sham operation, AP, and acute pancreatitis hypothermia (APH) rat models.
Results
Compared with the AP group, the APH group exhibited decreased amylase levels and decreased expression of cytokines after surgery. Moreover, 289 differential metabolites and three main metabolic pathways (ascorbate and aldarate metabolism, pentose and glucuronate interconversion, and tryptophan metabolism) were identified in the APH and AP groups.
Conclusions
Intragastric local hypothermia intervention reduced the expression of inflammatory cytokines and reduced the level of blood amylase and pancreatic pathological damage in rats with AP. This study provides a theoretical reference for the intervention of local hypothermia in the stomach in early pancreatitis.
Objective evaluation of the round window access in computed tomography for cochlear implantation
Authors: Amernik Katarzyna , Mielnik Michał , Gostyński Marcin , Dzięciołowska-Baran Edyta 
Published: October 2023

Abstract
Objective
The aim of this study was to determine what kind of radiological parameters are the best for assessing RW approach for CI surgery.
Material and Methods
Patients undergoing cochlear implantation between 2015 and 2022 were eligible for the study. Radiological assessment was performed according to parameters proposed in literature. Clinical assessment was made intraoperative. The difference in the assessment of accessibility to the round window niche and the round window membrane (RWN - RWM) indicated the clinical assessment of the size of the overhang over the round window.
Results
Computed tomography images of 57 ears in 52 patients were analyzed in terms of round window access. The study group included 26 women and 26 men, ranging in age from 1 year to 80 years, with a mean age of 36.2. In clinical assessment RW visibility was rated as 5 after removal of the bony overhang in 69% of patients. Cochlear access through the round window was performed in 39 patients, extended access through the round window in 13 cases and cochleostomy in 5 patients. Statistically significant correlations describing RW access were found for parameters proposed by Chen and by us. From parameters describing bony overhang of the RW positive correlation was found for Sarafaz and Mehanna parameters.
Conclusion
Radiological measurements describing access to the RW, determining the angle based on the anatomy of the posterior wall of the auditory canal and the position of the facial nerve, are of the highest value.
Clinical relevance statement
In the future, the use of algorithms for CT evaluation and robotic surgery will require parameters for assessing RW access to plan surgical access and the type of electrodes. The parameters proposed by various authors are summarized, which allows us to assess their usefulness in further clinical practice.
Switch of innate to adaptative immune responses in the brain of patients with Alzheimer’s disease correlates with tauopathy progression
Authors: Costa Marcos 
Published: October 2023

Abstract
Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, I analyze single-cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD and show evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8 + T cells becoming more frequent at advanced Braak stages.
Navigating the future of Alzheimer's care in Ireland - A service model for disease-modifying therapies in small and medium-sized healthcare systems
Authors: Leroi Iracema , Dolphin Helena , Dinh Rachel , Foley Tony , Kennelly Sean , Kinchin Irina , O'Caoimh Rónán , O’Dowd Sean , O’Philbin Laura , O’Reilly Susan , Trepel Dominic , Timmons Suzanne 
Published: October 2023

Abstract
Background
A new class of antibody-based drug therapy with the potential for disease modification is becoming available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of disease modifying therapies (DMTs) necessitates adopting new models of treatment and care pathways. A working group was convened to consider the implications of and health system readiness for DMTs for AD.
Aims
To describe a service model for the detection, diagnosis, and management of early AD in the Irish context and to provide a template for similar small-medium size healthcare ecosystems.
Methods
A series of facilitated workshops with a multidisciplinary working group, including Patient and Public Involvement (PPI) members, was carried out. This informed a series of recommendations for the implementation of new DMTs using an evidence-based conceptual framework for health system readiness based on (1) material resources and structures and (2) human and institutional relationships, values, and norms.
Findings:
We describe a hub-and-spoke model, which utilises the existing dementia care ecosystem as outlined in the Model of Care, with Regional Specialist Memory Services acting as central hubs and Memory Assessment and Support Services functioning as spokes for less central areas. We provide criteria for DMT referral, eligibility, administration, and ongoing monitoring. We propose that this model is replicable for other healthcare systems of comparable size and scope.
‘Enough is Enough’: A Mixed Methods Study on the Key Factors Driving UK NHS Nurses’ Decision to Strike
Authors: Sanfey Daniel 
Published: October 2023

Abstract
Background
The UK National Health Service (NHS) is one of the largest employers in the world and employs around 360,000 registered nurses. Following a protracted pay dispute in December 2022 NHS nurses engaged in industrial action resulting in the largest nurse strikes in the 74-year history of the NHS. Initially it appeared these strikes were a direct consequence of pay disputes but evidence suggests that the situation was more complex. This study aimed to explore what the key factors were in driving UK NHS nurses’ decision to strike.
Methods
A convergent parallel mixed methods design was used. The study was conducted throughout the UK and involved participants who were nurses working for the NHS who voted in favour of strike action. Data collection involved the use of an online survey completed by 468 nurses and 13 semi-structured interviews. Descriptive and inferential statistics were used for quantitative data analysis and a process of inductive thematic analysis for the qualitative data. The quantitative and qualitative data were analysed separately and then integrated to generate mixed methods inferences.
Results
The quantitative findings showed that patient safety, followed by staff shortages, pay, and unmanageable work demands were the most important factors encouraging nurses’ decision to strike. The qualitative findings served to further the understanding of these factors particularly in relation to participants’ perception of the NHS and the consequences of inadequate pay and staff shortages. Three overarching and overlapping themes represented the qualitative findings: Save our NHS, Money talks, and It’s untenable. Integration of the findings showed a high level of concordance between the two data sets and suggest that the factors involved are interconnected and inextricably linked.
Conclusions
The UK NHS is a challenging and demanding work environment in which the well-being of its patients is dependent on the well-being of those who care for them. Concerns relating to patient welfare, the nursing profession and the NHS played a large part in driving UK NHS nurses’ decision to strike. In order to address these concerns a focus on recruitment and retention of nurses in the NHS is needed.
WITHDRAWN: Rohingya Women’s Knowledge about Pregnancy Termination in Cox’s Bazar, Bangladesh: A Community-Based Study in Four Camps
Authors: Moore Ann M. , Afsana Kaosar , Mondal Pragna Paramita , Tignor Mira , Mulhern Octavia , Hussain Rubina , Hossain Altaf 
Published: October 2023

Abstract
Background: In 2017, approximately 770,000 Rohingya people were forcibly displaced from Myanmar and fled to Bangladesh and are currently residing in camps in Cox’s Bazar. Myanmar has a restrictive abortion law; in Bangladesh, menstrual regulation (MR) is legally allowed on demandup to 12 weeks after a woman’s last menstrual period. Little is known about how displaced Rohingya women are managing unintended pregnancies in Bangladesh.
Methods: We collected data on women’s knowledge of abortion-related services in the camps for displaced people through a multistage random sample household survey with ever-married women of reproductive age (n=1173) sampled from four camps. One woman per household was selected; the survey was conducted in Rohingya and lasted approximately an hour and twenty minutes.
Results: 52% of respondents in this sample knew of both pills and surgical methods to end a pregnancy while 23% had heard of neither method. 92% of respondents knew that health facilities provide MR. Only one-third knew that MR can be provided up to 11-12 weeks post last menstrual period with most respondents thinking that the maximum gestational age at which MR could be provided was eight weeks or less. Ease of access and long wait times at facilities were the primary reasons that respondents thought a woman might prefer to get pills to terminate a pregnancy somewhere other than a health facility. Being unmarried was the most common reason respondents though women could end a pregnancy legally. Reasons that respondents thought women should be able to end a pregnancy that they thought were not currently allowed reasons were when there are marital problems and when the woman gets pregnant from an extramarital affair. Ninety-nine percent believe a husband’s consent should be required for a woman to end a pregnancy.
Conclusions: While knowledge about availability of pregnancy termination services from health facilities and trust in health facilities is high, there is room for improvement on education about gestational ages at which MR is legal and reasons for being able to access MR. Husband’s role in women’s healthcare underscores the importance of including men in health education and access in this context.
Correct stimulation of CD28H arms NK cells against tumor cells
Authors: HASPOT Fabienne , Duplouye Pierre , Leau Raphaëlle , Huchet Virgnie , Nerrière-Daguin Véronique , Martinet Bernard , Danger Richard , Braudeau Cécile , Josien Régis , Blancho Gilles 
Published: October 2023

Abstract
Tumor evasion has recently been associated with a new member of the B7 family, HHLA2, mostly overexpressed on PDL1neg tumors. HHLA2 can either induce a costimulation signal when binding to CD28H or inhibition by binding to KIR3DL3 on T and NK cells. Given the broad distribution of CD28H on NK cells and its depicted role, we compare in this study two monoclonal antibodies targeting this new NK cell engager. We show that targeting CD28H at a specific epitope not only strongly activates Ca2+ flux but also results in NK cell activation. CD28H-activated NK cells further display increased cytotoxic activities against hematopoietic cell lines and bypass HHLA2 and HLA-E inhibitory signals. Additionally, scRNASeq analysis of clear cell kidney cancer cells (ccRCC) reveals that HHLA2+ ccRCC tumors are infiltrated with CD28H+NK cells which thus could be targeted by finely chosen anti-CD28H Abs.
Physiotherapists’ assessment of psychosocial factors in individuals with musculoskeletal pain: A scoping review
Authors: Alqarni Abdullah 
Published: October 2023

Abstract
This study aims to review physiotherapists’ practice in assessing psychosocial factors in individuals with musculoskeletal pain. A comprehensive electronic search was conducted on May 2022 in four databases: PubMed, Web of Science, Science Direct, and Scopus. Two reviewers independently screened retrieved studies for potential inclusion in the review. Data were extracted by two independent reviewers using a standardized extraction form. A total of 15 studies were included. Physiotherapists assessed musculoskeletal pain using the biomedical model, with little consideration of the assessment of psychosocial factors. Although physiotherapists were aware of the importance of assessment of the psychosocial factors, those factors were not routinely assessed in clinical practice. In general, some physiotherapists have informally assessed the psychosocial factors during patients’ interviews\dialogues, while others rely on gut feelings during patients’ interviews to identify psychosocial factors. Formal screening of psychosocial factors using validated questionnaires was not part of the routine clinical practice of physiotherapists. Multiple factors were described to be the barriers to such assessment including lacked education in assessing psychosocial factors, the need for skills and training on such assessment, and insufficient treatment session duration.
Acute common peroneal nerve injury after posterior lumbar decompression surgery
Authors: Wang Peng Wei , Chung Ming Hsuan , Hueng Dueng Yuan , Hsia Chung Ching 
Published: October 2023

Abstract
Background
Spine surgery is a prevalently performed procedure. Some authors have proposed an age-related surge in surgical and general complications. During spine surgery, patients are placed in positions that are not physiologic, would not be tolerated for prolonged periods by the patient in the awake state, and may lead to complications. Understanding these uncommon complications and their etiology is pivotal to prevention and necessary.
Case presentation
The patient is a 76-year-old woman referred to the outpatient department of neurosurgery in February 2022 by her physiatrist with a chief complaint of chronic low back pain in the left leg. Lumbar spine magnetic resonance imaging revealed degenerative disc disease and posterior disc bulging at the levels of L2/3 ~ L5/S1 with compression of the thecal sac. After receiving anti-inflammatory medication, nerve block and caudal block, her symptoms persisted. She was referred to a neurosurgeon for surgical intervention. We diagnosed spinal stenosis with left L3 and L4 radiculopathy, and elective decompression surgery was scheduled a few days later. We performed discectomies at L2/3 and L3/4 and left unilateral laminotomy at L2 and L3 for bilateral decompression. Following an uneventful surgery, the patient was extubated, and her left leg pain improved, but pain over the right outer calf with drop foot developed. A second lumbar MRI the next day revealed no evidence of recurrent disc herniation or epidural hematoma. Then, she received nerve conduction velocity and needle electromyogram on postoperative day 2, and the studies indicated right common peroneal nerve entrapment neuropathy. After medication with steroids and foot splint use, right leg pain improved. However, weak dorsiflexion of the right ankle persisted. We referred this patient to a physiatrist and OPD for follow-up after discharge.
Conclusion
PPNI is most commonly caused by peripheral nerve ischemia due to abnormal nerve lengthening or pressure and can be exacerbated by systemic hypotension. Any diseases affecting microvasculature and anatomical differences may contribute to nerve injury or render patients more susceptible to nerve injury. Prevention and early detection and intervention are paramount to reducing PPNI and associated adverse outcomes. The use of intraoperative neuromonitoring theoretically allows the surgical team to detect and intervene in impending PPNI during surgery.
A Posteriori Error Estimation for Model Order Reduction of Parametric Systems
Authors: Feng Lihong , Chellappa Sridhar , Benner Peter 
Published: October 2023

Abstract
This survey discusses a posteriori error estimation for model order reduction of parametric systems, including linear and nonlinear, time-dependent and steady systems. We focus on introducing the error estimators we have proposed in the past few years and comparing them with the most related error estimators from the literature. For a clearer comparison, we have translated some existing error bounds proposed in function spaces into the n-dimensional complex coordinate space and provide the corresponding proofs. Some new insights into our proposed error estimators are explored. Moreover, we review our newly proposed error estimator for nonlinear time-evolution systems, which is applicable to reduced-order models solved by arbitrary time-integration solvers. Our recent work on multi-fidelity error estimation is also briefly discussed. Finally, we derive a new inf-sup-constant-free output error estimator for nonlinear time-evolution systems. Numerical results for two examples show the robustness of the new error estimator.
A Microwave-Based Method for Early Detection of Congestive Heart Failure
Authors: Anand Aditi , Vaidyam Amrutha , Chandrasekar Adithya , Chandrashekar Atthin , Chi Alan , Groneck Adam , Luo Jiayu , Huene Christin , Lucas Alec , Cacciapuoti Lorenzo 
Published: October 2023

Abstract
We propose a microwave-based method for the early detection of Congestive heart failure (CHF). The proposed method is based on the prevalence of pulmonary edema accompanying CHF. Current approaches based on chest radiographs can only detect relatively high levels of pulmonary edema, limiting their efficacy for early diagnosis. We observe that microwaves passing through the thoracic cavity would experience significantly higher attenuation in the presence of fluid. Our detection method consists of a microwave source in the form of a two-dimensional array of low-power emitters placed on one side of the thoracic cavity, a corresponding array of receivers on the other side, and signal processing to compute the attenuation of microwaves as they pass through the body. We develop an electromagnetic simulation model to evaluate the proposed method and apply it to compute microwave attenuation in the absence and presence of various levels of pulmonary edema. Our experiments suggest that the method is sensitive to even mild and moderate levels of pulmonary edema that are difficult to detect using current first-line diagnostic methods. Our work makes a case for microwave-based detection as a safe, low-cost diagnostic method for CHF at earlier stages where there is a good potential for improved patient outcomes.
Evaluating the Disaster Preparedness of Emergency Medical Services (EMS) Facilities: A Cross-Sectional Investigation in Iran
Authors: Beyramijam Mehdi , aminizadeh Mohsen , Akbari-Shahrestanaki Yousof , khankeh Hamidreza 
Published: October 2023

Abstract

Introduction: The preparedness of Emergency Medical Services (EMS) plays a crucial role in managing and reducing health disaster risks. This study was conducted to assess the disaster preparedness of EMS facilities in Iran, using a nationally reliable tool. Methods A total of 52 EMS facilities in Iran were chosen for assessment in a cross-sectional study conducted through a census approach and their preparedness was evaluated to respond to emergencies and disasters. Results During the evaluation of the initial five hazards at each EMS center, a total of 31 hazards were recognized. Earthquakes, road traffic accidents, and floods were the most commonly cited by the majority of the EMS facilities. The results indicated that the majority of EMS facilities in Iran exhibit a moderate level of overall disaster preparedness. Additionally, when assessing the preparedness of EMS facilities across key domains of the research tool, it was observed that EMS facilities have average preparedness in all areas, except for "Coordination and Cooperation " and "surge capacity". The results of the independent t-test revealed a statistically significant difference in the mean disaster preparedness scores between two groups of EMS facilities: one group that had conducted training courses (maneuvers) in the past year and another group that had not undergone any training courses (p = 0.001)." Nonetheless, the Pearson correlation analysis failed to reveal a significant relationship between the variable "the number of exercises(drill) conducted in the past year" and the facility's mean overall disaster preparedness score (r = 0.270, n = 52, P = 0.061). Conclusion The findings from this study indicated that a majority of EMS facilities in Iran are exposed to potential hazards such as earthquakes, floods, traffic collisions, droughts, and epidemics. Furthermore, the investigations revealed that while Iranian EMS facilities generally exhibit a moderate level of preparedness to respond to emergencies and disasters, additional endeavors are required to enhance preparedness in the domains of coordination and cooperation, and surge capacity.