bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Quality of Life of Parents with Children Affected by Acute Lymphoblastic Leukemia: A Study at Childhood Cancer International Foundation, Jakarta
Authors: Trisya Michelle , Tjhay Francisca , Hasan Surilena , Widjaja Nelly Tina 
Published: December 2023

Background: The diagnosis and management of chronic diseases, such as Acute Lymphoblastic Leukemia (ALL), are significant for the quality of life of parents. In addition, several factors contribute to the quality of life of parents whose children battle ALL, including characteristics, duration of childcare, mental health, and family functioning. Therefore, this study aims to identify factors influencing the quality of life of parents whose children have ALL at the Childhood Cancer International Foundation in Jakarta. Methods: This cross-sectional study recruited 109 parents at the Childhood Cancer International Foundation as respondents. The assessment tools used included a Characteristics questionnaire, Self-Rating Questionnaire-20, APGAR Questionnaire, and WHOQOL-BREF questionnaire. Additionally, collected data were subjected to univariate, bivariate, and multivariate analysis. Results: Among the 109 respondents with an average age of 38 years and mean childcare duration of 28 months, 66.1% were females, 100% believed in God, 73.4% had partners, 47.7% possessed higher education, 83.5% earned below the regional minimum wage, 66.1% experienced mental health problems, and 11.9% had family dysfunction. Bivariate analysis showed a significant relationship between gender, mental health, and quality of life (p<0.05). Multivariate analysis showed that marital status, education, economic status, and family functioning significantly correlated with quality of life. Conclusions: In conclusion, gender, marital status, education, economic status, mental health, and family functioning were found to exert a significant influence on the quality of life of parents raising children with ALL.
Upcoming Events at Community-Based Research Canada until December 16, 2021
Authors: Clausen Kurt W. 
Published: December 2023

Community-Based Research Canada offers ongoing events including the webinars “Community of Practice: Community-Based Research Organizational Culture” on October 15, 2021, “Shift: Documenting the Impact of the COVID-19 Pandemic on Community-Based Research and Identifying Opportunities” on November 11, 2021, and “Closing the Opportunity Gap for Racialized and Under-Resourced Communities through the Community School Initiative” on December 9, 2021.
Link to information: https://www.communityresearchcanada.ca/events
Action Learning / Action Research Publications Webinar – May 12, 2022
Authors: Canadian Journal of Action Research  
Published: December 2023

Do you want to publish your values-driven research for systemic change? CJAR will be taking part in a webinar with 11 other journals to offer an opportunity for aspiring authors to gain advice on how to get their papers published - at no cost! Authors wishing to submit a paper must register by April 20.
To find out more about this webinar, submitting a paper for review, and how to register, further details are here: https://www.alarassociation.org/events/alara-webinars/publishing-your-research-May-22
CARN – D.A.CH. Conference 2023
Authors: CJAR  
Published: December 2023

The 10th CARN D.A.CH. conference will be held at the University College of Teacher Education Styria (Austria) on the 9th & 10th of February, 2023. All those interested in discussing action research in German are very warmly welcome. To submit an abstract and/or register, please see the Conference Flyer, linked below.
CARN D.A.CH. is a German-language Action Research network and part of the international Collaborative Action Research Network (CARN).
Click to view the Conference Flyer
See full annoucement in PDF attachment.
In Vitro Investigation of Shear Bond Strength of Titanium Alloy Bonded to Monolithic Zirconia Prepared Via Different Surface Roughening Methods Using Different Cements
Authors: ÇAKIR Gülay , ŞANIVAR ABBASGHOLIZADEH Zeliha , ASLAN Yılmaz Umut 
Published: December 2023

Objective: To evaluate the shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystals bonded to titanium alloys via different surface treatment methods using four different cements.
Methods: Eighty titanium and monolithic zirconia discs were prepared with computer-aided design/manufacturing (CAD/CAM) technology. All titanium discs and 40 of monolithic zirconia discs were polished by using silicon carbide paper and sandblasted with 50 μm aluminum oxide (Al2O3). Tribochemical silica coating was applied to remaining 40 monolithic zirconia discs. The monolithic zirconia discs were divided into eight groups after surface treatment (n=10). Titanium discs were cemented using conventional glass ionomer cement (GIC), resin-modified GIC, self- adhesive resin cement, and dual-cure resin cement. The SBS test was performed using a universal testing machine. The failure patterns were examined by using a scanning electron microscope (SEM). Data were statistically analyzed with one-way analysis of variance (ANOVA), two-way ANOVA and Tukey’s test (α
Effect of Zuclopenthixol Acetate on Neural Tube Development in Early Chick Embryos
Authors: ALBAŞ KURT Gülan , SARITAŞ Alperen , ATAY Emre , ERTEKİN Ayşe , KUNDAKCI Yunus Emre , ERTEKİN Tolga 
Published: December 2023

Objective: Neural tube defects are one of the congenital malformations of the central nervous system. Although the factors that cause the development of neural tube defects and their mechanisms of action are still not clearly explained, genetic predisposition, drug use and some environmental factors are thought to play a role. In this study, it was aimed to investigate the effects of zuclopenthixol acetate (ZA) on neural tube development in a chick embryo model.
Methods: Fourty specific pathogen-free (SPF) eggs were used in the study. The eggs were incubated for 28 hours and divided into four groups of 10 eggs each. At the end of the 28th hours, saline was injected to the control group, while ZA was administered subblastodermically to the experimental groups in 3 different doses (0.7, 1.4, 2.1 mg/kg). At the end of the 48th hours, all the eggs were opened and the embryos were dissected from the embryonic membranes and evaluated morphologically and histopathologically.
Results: When the study groups were evaluated according to the neural tube positions (open or closed), it was found that the neural tube patency increased depending on the ZA dose, which was statistically significant (p < 0.05). In addition, morphological developments of embryos were evaluated. Compared to the control group, a statistically significant decrease was observed in the mean somite numbers in all ZA-treated groups, while a significant decrease was found in the mean cranio-caudal length only in the high-dose group.
Conclusion: In this study, it was observed that neural tube and morphological development were adversely affected in the groups treated with ZA in the chick embryo model. It was shown that neural tube closure defects in embryos increased in direct proportion with ZA doses. However, we believe that it will not be possible to fully adapt the results of this study, which was carried out in the chick embryo model, to humans and that more comprehensive research should be conducted.
Participation in a multicomponent lifestyle intervention for people with obesity improves glycated hemoglobin (HbA1c)
Authors: Høgsholt Mathias , Kierkegaard-Brøchner Signe , Sørensen Ulla Milther , Lange Lene Bastrup , Mortensen Lene Sundahl , Bruun Jens Meldgaard 
Published: December 2023

IntroductionObesity is associated with compromised glucose metabolism. Hence, it is of interest to investigate if the lifestyle interventions used in the LIBRA-cohort, which aimed at not only weight loss, but also patient well-being, could also help obese patients improve glucose metabolism by evidence of reduced HbA1c. The aim of the study was to retrospectively investigate if patients who were referred to a lifestyle intervention for obesity, were able to alter HbA1c.Research design and methodsPatients with a BMI≥30 undergoing a 6-month lifestyle intervention, who also completed physical and mental health surveys and whose baseline and 6-month blood samples were available, were included in the analysis. For changes in HbA1c and body weight a clinically relevant change of 5≥mmom/mol and 5%≥, respectively, was chosen. Participants were divided into groups according to their baseline HbA1c level: “Diabetes”: HbA1c of ≥6.5% (≥48 mmol/mol), “Prediabetes”: HbA1c of 5.7% to 6.4% (39-47.99 mmol/mol) or “Normal” HbA1c &lt;5.7% (&lt;39 mmol/mol).Results180 patients met the stated inclusion criteria and these patients were divided into groups (median age (25th;75th quartile): Diabetes: n=47, age 54 (43;60), 51% women, Prediabetes: n=68, age 60 (50;66), 71% women and Normal: n=65, median age 61 (50;66), 85% women. Significant reductions were found in all three groups and specifically in the diabetes group HbA1c was reduced (mean [95%CI]) -5[-8;-2] mmol/mol from baseline to the end of the intervention. Furthermore, 35% of patients with prediabetes normalized their HbA1c (&lt;39) and 30% patients with diabetes reduced their HbA1c &lt;48. All groups had clinically relevant (≥5%) reductions in body weight (p&lt;0.01). There was an association between body weight reduction and HbA1c reduction in the diabetes group (p&lt;0.01). All groups reported improvements in physical health (p&lt;0.01).ConclusionIn this retrospective cohort study, all patients achieved clinically relevant weight loss after participation in the lifestyle intervention and obese patients with diabetes achieved clinically relevant reductions in HbA1c after 6-months. More than 1/3 of patients with prediabetes normalized their HbA1c.
The metaproteome of the gut microbiota in pediatric patients affected by COVID-19
Authors: Marzano Valeria , Mortera Stefano Levi , Marangelo Chiara , Piazzesi Antonia , Rapisarda Federica , Pane Stefania , Del Chierico Federica , Vernocchi Pamela , Romani Lorenza , Campana Andrea , Palma Paolo , Putignani Lorenza ,   the CACTUS Study Team
Published: December 2023

IntroductionThe gut microbiota (GM) play a significant role in the infectivity and severity of COVID-19 infection. However, the available literature primarily focuses on adult patients and it is known that the microbiota undergoes changes throughout the lifespan, with significant alterations occurring during infancy and subsequently stabilizing during adulthood. Moreover, children have exhibited milder symptoms of COVID-19 disease, which has been associated with the abundance of certain protective bacteria. Here, we examine the metaproteome of pediatric patients to uncover the biological mechanisms that underlie this protective effect of the GM.MethodsWe performed nanoliquid chromatography coupled with tandem mass spectrometry on a high resolution analytical platform, resulting in label free quantification of bacterial protein groups (PGs), along with functional annotations via COG and KEGG databases by MetaLab-MAG. Additionally, taxonomic assignment was possible through the use of the lowest common ancestor algorithm provided by Unipept software.ResultsA COVID-19 GM functional dissimilarity respect to healthy subjects was identified by univariate analysis. The alteration in COVID-19 GM function is primarily based on bacterial pathways that predominantly involve metabolic processes, such as those related to tryptophan, butanoate, fatty acid, and bile acid biosynthesis, as well as antibiotic resistance and virulence.DiscussionThese findings highlight the mechanisms by which the pediatric GM could contribute to protection against the more severe manifestations of the disease in children. Uncovering these mechanisms can, therefore, have important implications in the discovery of novel adjuvant therapies for severe COVID-19.
Spatiotemporal distribution characteristics and influencing factors of the rate of cardiovascular hospitalization in Ganzhou city of China
Authors: Yan Shanshan , Liu Guoqiu , Chen Xiaoyuan 
Published: December 2023

AimsThe objective of this study was to analyze hospitalization rates for cardiovascular diseases (CVD) in Ganzhou City, Jiangxi Province of China from 2015 to 2020 and to uncover the spatiotemporal distribution characteristics and influencing factors, and thus to provide reference for the prevention and control of CVD and public health resources planning.MethodsThe hospitalization data for CVDs from 2016 to 2020 was obtained from the First Affiliated Hospital of Gannan Medical University, and ArcGIS 10.8, SaTScan 9.5, and Matlab 20.0 were used to analyze the spatial autocorrelation, spatiotemporal scan statistics, and potential affecting factors of the hospitalization rates.ResultsThe hospitalization rate for CVDs in Ganzhou City showed a slightly increasing trend from 2016 to 2020, with higher rates in winter and summer than that in spring and autumn, and the individuals aged 61 and above constitute a higher proportion compared to other age groups. Additionally, there was a positive correlation between hospitalization rates for CVDs and the counties and districts in Ganzhou City, with high-high aggregation areas mainly distributed in Nankang District, the western urban area of Ganzhou City. The spatial scan analysis identified three different types of significant aggregation areas: high-risk, low-risk, and middle-risk areas. The high-risk area was mainly centered around Zhanggong District or Shangyu County in the central and western regions, with a disease hospitalization rate 2–3 times higher than the rest areas. The study also found that environmental meteorological factors such as the annual average concentration of NO2, O3, average annual temperature, and annual maximum temperature diurnal range had a significant positive effect on hospitalization rates for CVDs in Ganzhou City, with O3 concentration and average annual temperature having significant positive indirect spatial spillover effects.ConclusionWinter and summer are the seasons with high hospitalization rate of cardiovascular diseases. County residents aged 61 and above are the higher-risk population that needs to pay more attention on for prevention and control of CVD in Ganzhou City, which exhibits significant spatiotemporal clustering. The urban areas of Zhanggong and Nankang in Ganzhou City are the key areas for prevention and control of CVD. The hospitalization rate of CVD in Ganzhou City is influenced by the aforementioned four environmental meteorological factors, with the annual maximum temperature diurnal range showing the most significant positive direct effect.
Preoperative risk stratification for patients with ≤ 1 cm papillary thyroid carcinomas based on preoperative blood inflammatory markers: construction of a dynamic predictive model
Authors: Zhao Lingqian , Hu Tao , Cai Yuan , Zhou Tianhan , Zhang Wenhao , Wu Fan , Zhang Yu , Luo Dingcun 
Published: December 2023

ObjectiveThe aim of this study was to investigate the relationships and predictive value of preoperative peripheral blood inflammatory markers as a means by which to assess risk for patients with ≤ 1 cm papillary thyroid carcinomas (PTCs). In addition, a preoperative risk stratification predictive model was constructed and validated.MethodsClinical and pathologic data, as well as preoperative blood specimens, were collected from patients who underwent initial thyroid cancer surgery at the Hangzhou First People’s Hospital, from January 2014 to January 2023. Risk assessment was performed based on postoperative pathology according to the 2015 ATA guidelines for recurrence risk stratification. Using univariate analysis and multivariate logistic regression, we identified independent risk factors associated with risk stratification. A predictive model was established and its discriminative and calibration abilities were validated. An independent validation dataset was used to verify the model, and the model was deployed as an online calculator.ResultsA total of 1326 patients were included in the study, with 1047 cases (79.0%) classified as low risk and 279 cases (21.0%) classified as intermediate to high risk. The modeling group consisted of 981 cases, through univariate analysis and multivariate logistic regression analysis, preoperative blood Neutrophil/Lymphocyte Ratio (NLR), gender, tumor diameter, and multifocality were identified as independent risk factors that distinguished between low and intermediate to high risk patients with ≤ 1 cm PTCs. The clinical predictive model exhibited an AUC of 0.785, specificity of 70.6%, and sensitivity of 75.8%. For the independent validation group of 345 patients, the AUC was 0.813, specificity was 83.8%, and sensitivity was 70.4%. The calibration curve and clinical decision curve indicate that the model demonstrates excellent calibration performance.ConclusionA dynamic clinical predictive model based on preoperative blood NLR and clinical information for patients with ≤ 1 cm PTCs was established. The model is useful for preoperative risk assessment of patients with ≤ 1 cm PTCs.
Variant spectrum of F8 and F9 in hemophilia patients from southern China and 26 novel variants
Authors: Li Fucheng , He Liya , Chen Guilan , Lu Yan , Li Ru , Zhang Yongling , Jing Xiangyi , Ling Rujuan , Li Dongzhi , Liao Can 
Published: December 2023

Hemophilia, an X-linked recessive disorder, is characterized by spontaneous or trauma-induced prolonged bleeding. It is classified as hemophilia A when caused by variants in the F8 gene, and hemophilia B when caused by F9 variants. Few studies have described hemophilia variants in the Chinese population. This study aimed to investigate the clinical and genetic profiles of 193 hemophilia patients from southern China. Utilizing Sanger sequencing, multiplex ligation-dependent probe amplification, gap detection, long-range PCR, and multiplex PCR, we identified both F8 and F9 gene variants. Pregnant women with a history of hemophilia A offspring underwent amniocentesis or villus sampling for the variant detection. Variants in F8 and F9 were pinpointed in 183 patients, with 26 being novel discoveries. Notably, genetic testing was absent in the initial evaluation of 133 out of 161 patients, leading to a protracted average definitive diagnosis timeline of 2 years. Remarkably, two hemophilia A cases with anticipated severe phenotypes due to protein-truncating variants presented with only moderate or mild clinical manifestations. Among the 40 fetuses tested, 34 were males, with 17 exhibiting hemizygous variants in the F8 gene. Our results contribute to the broader understanding of F8 and F9 variant spectrum and highlight the underuse of genetic analyses in southern China.
IgG4-related disease with massive pericardial effusion diagnosed clinically using FDG-PETCT: a case report
Authors: Wei Qiaofeng , Qi Huili , Wei Hongmei , Wang Xiuhua , Zhang Hongju 
Published: December 2023

BackgroundIgG4-related disease (IgG4-RD) is a systemic inflammatory disease which involves various organs such as the pancreas, lacrimal gland, salivary gland, retroperitoneum, and so on. These organs can be affected concomitantly. 18-Fluorodeoxyglucose positron emission tomography computed tomography (FDG-PETCT) is a systemic examination which can identify active inflammation and detect multiple organ involvement simultaneously. Pericardial involvement is rare in IgG4-RD, early detection and treatment can greatly improve the prognosis of patients.Case summaryWe reported a 82-year-old female patient referred to our department complaining of chest tightness and abdominal fullness for 8 months and massive pericardial effusion for 2 months. A large amount of pericardial effusion was found during the hospitalization of Gastroenterology. Then she was transferred to cardiology. Although infectious, tuberculous, and neoplastic pericardial effusions were excluded, there was still no diagnosis. The patients were examined by FDG-PETCT which considered IgG4-RD. After coming to our department, the results of the patient’s laboratory tests showed that immunoglobulin subgroup IgG4 was 14.0 g/L. Then we performed a biopsy of the right submandibular gland. Pathological morphology and immunohistochemistry suggested IgG4-RD. Combined with level of IgG4, clinical, pathological and immunohistochemical results, we determined the final diagnosis of IgG4 related diseases. Then we gave glucocorticoid and immunosuppressant treatment. At the end, pericardial effusion was completely absorbed. As prednisone acetate was gradually reduced, no recurrence of the disease has been observed.ConclusionPericardial effusion can be the initial presentation in IgG4-RD. For patients with massive pericardial effusion of unknown cause, early detection of IgG4 is recommended, and PETCT may be helpful for obtaining the diagnosis.
Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients
Authors: Hageman Ishtu , Mol Femke , Atiqi Sadaf , Joustra Vincent , Sengul Hilal , Henneman Peter , Visman Ingrid , Hakvoort Theodorus , Nurmohamed Mike , Wolbink Gertjan , Levin Evgeni , Li Yim Andrew Y.F. , D’Haens Geert , de Jonge Wouter J. 
Published: December 2023

Background and aimsRheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα). Currently, there are no biomarkers to predict therapy response to these agents. Here, we aimed to predict response to adalimumab (ADA) treatment in RA patients using DNA methylation in peripheral blood (PBL).MethodsDNA methylation profiling on whole peripheral blood from 92 RA patients before the start of ADA treatment was determined using Illumina HumanMethylationEPIC BeadChip array. After 6 months, treatment response was assessed according to the European Alliance of Associations for Rheumatology (EULAR) criteria for disease activity. Patients were classified as responders (Disease Activity Score in 28 Joints (DAS28) &lt; 3.2 or decrease of 1.2 points) or as non-responders (DAS28 &gt; 5.1 or decrease of less than 0.6 points). Machine learning models were built through stability-selected gradient boosting to predict response prior to ADA treatment with predictor DNA methylation markers.ResultsOf the 94 RA patients, we classified 49 and 43 patients as responders and non-responders, respectively. We were capable of differentiating responders from non-responders with a high performance (area under the curve (AUC) 0.76) using a panel of 27 CpGs. These classifier CpGs are annotated to genes involved in immunological and pathophysiological pathways related to RA such as T-cell signaling, B-cell pathology, and angiogenesis.ConclusionOur findings indicate that the DNA methylome of PBL provides discriminative capabilities in discerning responders and non-responders to ADA treatment and may therefore serve as a tool for therapy prediction.