bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Thyroid Dysfunction and Hyperglycemia is More Significant in Females Younger Than 65 years old
Authors: Gao Xiaotong , Liu Shengyu , Wang Youmin , Wang Xichang , Zhang Jinan , Zhang Qiao , Zhao Jiajun , Li Yongze , Teng Weiping , Shan Zhongyan 
Published: February 2024

Abstract

Background
The significant association between different levels of thyroid dysfunction and hyperglycemia has been well-established. The purpose of our research is to provide new relevant evidence while verifying the preexisting views.
Methods
This is a cross-sectional analysis based on 31 provinces in mainland China. We excluded subjects with a personal history of thyroid diseases or diabetes. The diagnostic criteria of different types of hyperglycemia referred to the 2018 American Diabetes Association guidelines. We explored the trend of hyperglycemia prevalence with different levels of thyroid function in the general population (N = 56,700) and analyzed the potential association between them. In addition, we explored the relationship in subgroups with different demographics and anthropometrics.
Results
In the overall population, overt hyperthyroidism could be regarded as a significant risk factor for impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and prediabetes. Additionally, both overt hypothyroidism and severe subclinical hypothyroidism (thyrotropin > 7.04 mU/L) could be regarded as a significant risk factor for prediabetes and diabetes. The prevalence of diabetes significantly increased, and IGT showed a significant U-shaped distribution with thyrotropin. But we did not find the distribution of IFG and prediabetes prevalence with the increase of serum thyrotropin. Further subgroup analysis revealed that the abovementioned associations also had specific distribution rules in some particular population.
Conclusions
Thyroid dysfunction and hyperglycemia are significantly related. For particular subgroups with thyroid dysfunction, we should pay more attention to the association between the hyperglycemia and thyroid diseases.
Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism
Authors: Silva-Pavez Eduardo , Mendoza Elizabeth , Morgado-Cáceres Pablo , Ahumada-Castro Ulises , Bustos Galdo , Cardenas J. Cesar , Kangme-Encalada Matías , de Arbina Amaia Lopez , Puebla-Huerta Andrea , Muñoz Felipe , Cereceda Lucas , Varas-Godoy Manuel , HIdalgo Yessia 
Published: February 2024

Abstract

Increasing evidence supports the hypothesis that cancer progression is under mitochondrial control. Mitochondrial fission plays a pivotal role in the maintenance of cancer cell homeostasis. The inhibition of DRP1, the main regulator of mitochondrial fission, with the mitochondrial division inhibitor (mdivi-1) had been associated with cancer cell sensitivity to chemotherapeutics and decreased proliferation. Here, using breast cancer cells we find that mdivi-1 induces the detachment of the cells, leading to a bulk of floating cells that conserve their viability. Despite a decrease in their proliferative and clonogenic capabilities, these floating cells maintain the capacity to re-adhere upon re-seeding and retain their migratory and invasive potential. Interestingly, the cell detachment induced by mdivi-1 is independent of DRP1 but relies on inhibition of mitochondrial complex I. Furthermore, mdivi-1 induces cell detachment rely on glucose and the pentose phosphate pathway (PPP). Our data evidence a novel DRP1-independent effect of mdivi-1 in the attachment of cancer cells. The generation of floating viable cells restricts the use of mdivi-1 as a therapeutic agent and demonstrates that mdivi-1 effect on cancer cells are more complex than anticipated.
Impaired Macroautophagy in Oligodendrocyte Precursor Cells Exacerbates Aging-related Cognitive Deficits via a Senescence Associated Signaling
Authors: Ma Quan-Hong , Chen Hong , Sun Yan-Yun , Li Qi-Fa , Du Yu-Tong , Hu Na-Na , Huang Xin , Zhu Chao , Yang Gang , Tang Yong , Tao Jin , Feng Lei , Kirchhoff Frank , Huang Wenhui , Li Shao 
Published: February 2024

Abstract
Aging drives cognitive decline in the adult brain with unclear mechanisms. Previously, oligodendrocyte precursor cells (OPCs), the source cells of myelin-forming cells in the central nervous system (CNS), have been linked to brain aging by their compromised differentiation and regeneration capability. Whether a myelination-independent function of OPCs is involved in brain aging remains unknown. In this study, we herein report a novel role of OPCs in brain aging via disrupting neuronal plasticity. Our results demonstrate that macroautophagy influx declines in aged OPCs, which results in the accumulation of senescent OPCs in aged brains. Senescent OPCs impair neuronal plasticity and exacerbate neurodegeneration via CCL3/5-CCR5 signaling, eventually leading to cognitive decline. Our study, for the first time, demonstrates a myelination-independent role of OPCs in brain aging and identifies that a declined autophagy in OPCs is a driver of aging-associated cognitive decline.
A multimodal sentiment model based on causal gating attention mechanism
Authors: Gan Zhiqiang , Sun Xiang-e , Liu Meihua 
Published: February 2024

Abstract

Utilising a cross-modal attention mechanism for multimodal feature integration may engender confounding effects, resulting indetrimental biases during modal interaction, and consequently impacting the outcomes of emotion classification. To addressthis issue, a cross-modal fusion network based on causal gating attention mechanism was proposed. First, a feature-maskingtext embedding module is utilised to enhance the semantic representation capability of both the audio and video modalities.Subsequently, a cross-modal attention fusion module is employed to complementarily merge the audio and video modalities,obtaining the fused audio-video modality features. Next, a causal gating cross-modal fusion network is used to fully integratethe heterogeneous data of text, audio, and video modalities. Finally, the sentiment analysis results are classified using SoftMax.The proposed cross-modal fusion network demonstrated superior performance in sentiment classification when compared tobaseline techniques on the CMU-MOSEI dataset. It effectively associated and combined pertinent multi-modal information.
Theoretical analysis of the effect of isotropy on the effective diffusion coefficient in the porous and agglomerated phase of the electrodes of a PEMFC
Authors: Pacheco Carlos , Barbosa Romeli , Navarro-Montejo Alfonso , Ordoñez Luis Carlos 
Published: February 2024

Abstract
In polymer membrane fuel cells (PEMFC), the pore microstructure and the effective diffusion coefficient (\({D}_{eff}\)) of the catalytic layer have a significant impact on the overall performance of the fuel cell. In this wok, numerical methods to simulate PEMFC catalytic layers were used to study the effect of isotropy (\({I}_{xy}\)) on the \({D}_{eff}\). The proposed methodology studies reconstructed systems by Simulated Annealing (SA) imaging with different surface fractions of microstructures composed by two diffusive phases: agglomerates and pores. The \({D}_{Eff}\) is determined numerically by the Finite Volume Method (FVM) solved for Fick's First Law of Diffusion. The results show that the proposed methodology can effectively quantify the effect of isotropy on the \({D}_{eff}\) for both diffusion phases. Two trends were obtained in the magnitude of the \({D}_{eff}\) concerning the change in isotropy: a) when the surface fraction is more significant than 50%, the \({D}_{eff}\) decreases linearly at the beginning and exponentially at the end of the isotropy change, which indicates that small changes in isotropy in the particulate material modify it drastically. b) When the surface fraction is less than 50%, the \({D}_{eff}\) decreases exponentially at the beginning and linearly at the end of the isotropy change, which shows that small isotropy changes in the bar-aligned material drastically alter it. The proposed methodology can be used as a design tool to improve the mass transport in porous PEMFC electrodes.
Investigation Of Marginal Bone Loss In Implants With Different Surface Properties And Geometric Designs: A Retrospective Clinical Study
Authors: KARABAĞ Mert , GÜMRÜKÇÜ Zeynep , BAYRAK Seval 
Published: February 2024

Abstract

Objective
The aim of this study was to investigate the influence of surface characteristics and geometric design on marginal bone loss and bone quality in dental implants.
Materials and Methods
A total of 378 implants from 114 patients were categorized into 19 subgroups according to the upper/lower jaw, implant length/diameter/surface preparation/neck design, type of prosthetic superstructure. Radiological evaluations were conducted on marginal bone loss and fractal analysis of the bone.
Results
Marginal bone loss was significantly higher in the maxilla compared to the mandible when considering the changes between jaws (p < 0.05). Analysis of variations among prosthetic superstructures revealed that implant-supported removable prostheses had the highest marginal bone loss (p < 0.05). Additionally, marginal bone loss was significantly lower in implants with coronal microthreads not exceeding 1 mm compared to those exceeding 1 mm (p < 0.05). Also the increase in fractal values was significantly higher in implants with coronal microthreads 1 mm compared to 3 mm.
Conslusion:
The geometric design of dental implants may have an impact on marginal bone loss, which is a determinant of long-term success. However, considering that marginal bone loss has a multifactorial etiology, further studies are needed to identify other potential factors contributing to marginal bone loss.
Clinical Revelance:
The geometric characteristics of the implant, such as length, diameter, microthread design, and the bone quality in the placement area of ​​the implant are related to the prognosis of the implant. Therefore, implant success can be increased by considering these factors during implant planning.
Association of selenium and selenoprotein-P with markers of systemic inflammation in patients with polycystic ovary syndrome
Authors: Khademi Zeinab , Pourreza Sanaz , Hamedi-Shahraki Soudabeh , Amirkhizi Farshad 
Published: February 2024

Abstract
Backgrounds: Although the anti-inflammatory effects of Selenium (Se) have received significant attention, its contribution to systematic inflammation in polycystic ovary syndrome (PCOS) patients has not been studied before. Thus, this study aims to evaluate the correlations between Se and Selenoprotein P (SELENOP) with inflammatory markers in women with PCOS.
Methods: This cross-sectional study collected data from 125 females aged 18-45 diagnosed with PCOS according to the Rotterdam Consensus Criteria. Relevant questionnaires were used to gather necessary information on socio-demographic factors and physical activity. To assess systemic inflammation, the levels of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and nuclear factor k-B (NF-kB) were measured.
Results: Serum Se levels were found to be inversely correlated with serum levels of IL-6 (r=-228, p=0.010), TNF-α (r=-236, p=0.008), and NF-кB p65 (r=-282, p=0.001). Additionally, there were significant inverse associations between serum SELENOP levels and IL-6 (r=-208, p=0.020), TNF-α (r=-279, p=0.002), and NF-кB p65 (r=-249, p=0.005) serum levels. No significant correlation was found between Se or SELENOP levels and hs-CRP or IL-1β.
Conclusions: In conclusion, serum levels of Se and SELENOP were inversely correlated with inflammatory markers. Future prospective cohort studies are advised to further assess these findings.
Healthy Tissue Metabolism Assessed by [18F]FDG PET/CT as a Marker of Prognosis and Adverse Events in Advanced Hodgkin Lymphoma Patients
Authors: Malaih Afnan A. , Kirkwood Amy A. , Johnson Peter , Radhakrishnan Vivek , Barrington Sally F. , Fischer Barbara M. 
Published: February 2024

Abstract
The aim of the study was to assess healthy tissue metabolism (HTM) using [18F]FDG-PET/CT during chemotherapy in Hodgkin lymphoma (HL) and the association of HTM with baseline metabolic tumour volume (MTV), haematological parameters, adverse events (AEs), early response and progression-free survival (PFS). We retrospectively identified 200 patients with advanced HL from the RATHL trial with PET/CT before (PET0) and following 2 cycles of chemotherapy (PET2). [18F]FDG-uptake was measured in bone marrow (BM), spleen, liver and mediastinal blood pool (MBP). Deauville score (DS)1-3 was used to classify responders and DS 4-5, non-responders. [18F]FDG-uptake decreased significantly in BM and spleen and increased in liver and MBP at PET2 (all p< 0.0001), but was not associated with MTV. BM uptake at PET0 was associated with lower baseline haemoglobin and higher absolute neutrophil counts, platelets and white blood cells. BM, spleen and liver uptake at PET0 was associated with neutropenia after cycles 1-2. BM uptake at PET0 was associated with treatment failure at PET2 and non-responders with higher BM uptake at PET2 had significantly inferior PFS (p = 0.006; hazard ratio = 2.31). Change in HTM during chemotherapy was most likely a direct impact of chemotherapy rather than a change in MTV. BM uptake has a prognostic value in HL.
Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation
Authors: Sato Yu , Noguchi Hiroshi , Kubo Shinsuke , Kaku Keizo , Okabe Yasuhiro , Onishi Hideya , Nakamura Masafumi 
Published: February 2024

Abstract

Periodontitis is a chronic inflammatory disease that affects the periodontal tissues. Although it is associated with various systemic diseases, the impact of periodontitis on kidney transplantation (KT) outcomes, particularly allograft rejection, remains unclear. This study investigated the effect of periodontitis on transplant immunity, specifically examining Porphyromonas gingivalis-derived lipopolysaccharide (LPS-PG). In vitro experiments revealed that LPS-PG increased regulatory T cells (Tregs) in Lewis rat spleen cells. In a mixed lymphocyte reaction assay, concentrations of interferon-γ, indicative of alloreactivity, were lower than controls when LPS-PG was added to the culture and when LPS-PG-administered Lewis rat spleen cells were used as responders. In a rat KT model, LPS-PG administration to recipients promoted mild tubulitis and low serum creatinine and blood urea nitrogen levels 5 days post-KT compared with PBS-administered controls. Furthermore, LPS-PG-administered recipients had an elevated Treg proportion in their peripheral blood and spleen cells, and increased infiltrating Tregs in kidney allografts, compared with controls. The elevated Treg proportion in peripheral blood and spleen cells had a significant negative correlation with serum creatinine, suggesting elevated Tregs modulated allograft rejection. These findings suggest that periodontitis might modulate alloimmune reactivity through LPS-PG and Tregs, offering insights to refine immunosuppressive strategies for KT recipients.
The Main Features of Transformed Seawater Penetration in the Dniester River Mouth at Surges Caused by Storm Winds
Authors: Tuchkovenkо Yurii , Loboda Nataliia , Ovcharuk Valeriya 
Published: February 2024

Abstract
The article considers the possibility of brackish water rising from the Dniester Estuary up the Dniester River mouth, where Station “Dniester” supplies potable water to Odesa City and the intake point of the Lower Dniester Irrigation System is located. The study is topical as the brackish water threatens the quality of drinking and irrigation water at the intake waters. The purpose of the work has been to use hydrodynamic modelling to establish the hydro-meteorological conditions under which the transformed sea water from the Dniester Estuary could enter the mouth part of the Dniester. It has been established that the following conditions are to be met for the transformed marine water to rise into the estuarine arms of the Dniester River: (1) average daily river discharge decrease below 100 m3/sec; (2) domination of surge wind from south or south-east at a speed exceeding 15 m/sec for several days. Under such conditions, the transformed marine water rises from the estuary upstream into the Dniester River mouth through the right arm, the Glybokyi Turunchuk, and then, having reached the place where the main river channel divides into two arms, the estuarine water is driven into the left arm - the Dniester and, by it comes back to the estuary. The case described in the article could be used by experts as an example when identifying effective hydro-engineering measures to prevent transformed sea water penetration in river mouth by building a second estuarine canal (branch).
Host-Guest Complexation-Induced Chirality Switching of Pillararenes by Perylene Diimide-Based Hexagonal Metallacages
Authors: Zhang Mingming , Hou Yali , Mu Chaoqun , Shi Yunzhi , Zhang Zeyuan , Liu Haifei , Zhou Zilin , Chen Wei-Peng , Guo Chenxing , Ling Sanliang , Shi Bingbing , Duan Xianglong , Yang Cheng 
Published: February 2024

Abstract
Chirality in confined nanospaces has brought some new insights on chirality transfer, amplification and chiroptical properties. However, chirality switching, which is a common phenomenon in biological systems, has never been realized in confined environments. Herein, we report a type of hexagonal metallacages which shows good host-guest interactions with ethoxy pillar[5]arene, pillar[6]arene, as confirmed by single-crystal X-ray analysis. Importantly, when a chiral pillar[5]arene-based molecular universal joint (MUJ) is used as the guest, the host-guest complexation would drive the alkyl ring of the MUJ flip from outside to inside the cavity of its pillar[5]arene unit, which enables the configuration change along with the chirality inversion of the MUJ. Moreover, the host-guest complexation facilitates the chirality transfer from guests to hosts, giving circularly polarized luminescence for the system. This study provides a unique metallacage-pillararene recognition motif for the chirality switching of planar chiral pillararenes, which will promote the construction of host-guest systems with tunable chirality for advanced applications.
A novel homozygous RHOH variant associated with T cell dysfunction and recurrent opportunistic infections
Authors: Zhou Jingyu , Qian Mengqing , Jiang Ning , Wu Jing , Feng Xiaoqian , Yu Meiping , Min Qing , Xu Haoxin , Yang Yixuan , Yang Qingluan , Zhou Feiran , Shao Lingyun , Zhu Haoxiang , Yang Yun , Wang Ji-Yang , Ruan Qiaoling , Zhang Wenhong 
Published: February 2024

Abstract

RHOH, an atypical small GTPase predominantly expressed in hematopoietic cells, plays a vital role in immune function. A deficiency in RHOH has been linked to epidermodysplasia verruciformis, lung disease, Burkitt lymphoma and T cell defects. Here, we report a novel germline homozygous RHOH c.245G > A (p.Cys82Tyr) variant in a 21-year-old male suffering from recurrent, invasive, opportunistic infections affecting the lungs, eyes, and brain. His sister also succumbed to a lung infection during early adulthood. The patient exhibited a persistent decrease in CD4+ T, B, and NK cell counts, and hypoimmunoglobulinemia. Despite normal RHOH mRNA levels in his family, the patient’s T cell showed impaired activation upon in vitro TCR stimulation. In Jurkat T cells transduced with RHOHC82Y, a similar reduction in CD69 activation marker up-regulation was observed. However, ectopic expression of the C82Y variant did not exhibit a negative dominance over wild type RHOH. Furthermore, the C82Y variant showed reduced RHOH protein expression and impaired interaction with the TCR signaling molecule ZAP70. Together, these data suggest that the newly identified autosomal-recessive RHOH variant is associated with T cell dysfunction and recurrent opportunistic infections, functioning as a hypomorph by disrupting ZAP70-mediated TCR signaling.
Safety evaluation of a potential anti-rheumatoid arthritis candidate, levamisole
Authors: Wang Jun-Xiang , Zhang Jia Hui , Guo Mu , Huang Wei Rui , Zheng Han Lu , Liao Yi Qi , Yan Ying Xue , Lin Zhao Long , Qiu Neng Fu , Yu Xiang-Bin , Yu Yue 
Published: February 2024

Abstract
Backgrounds: Levamisole (LVM) is a non-specific immunomodulator with potential for treating skin conditions, tumors, and autoimmune disorders. However, the widespread reports of neurotoxicity caused by LVM as a cutting agent for cocaine have led to public panic and restricted its clinical use.
Methods: To investigate the potential toxicity of LVM and evaluate its effects in treating rheumatoid arthritis (RA), we conducted a 28-day oral administration study in SD rats, and assessed general toxicity and neurotoxicity via serum biochemical indicators, the Morris water maze test, transmission electron microscopy, and H&E staining. Subsequently, we evaluated the therapeutic effects of LVM on RA.
Results: In the LVM toxicity study, there were no significant differences in the histopathological slices, serum biochemical tests, and behavioral experiments of the treatment group compared to the control group; in the study of treating RA, LVM not only significantly improved the bone and joint erosion in rats induced by adjuvant, but also significantly reduced synovial hyperplasia and infiltration of inflammatory cells
Conclusions: This study showed that LVM has promising therapeutic effects in treating RA with negligible toxicity, and offer valuable insights for the clinical use of LVM in treating RA.
The study of variations in groundwater occurrence influencing the migration characteristics of LNAPL
Authors: Suo Kui , Zhao Ming Dong , Liu Yu , Liu Hong Wei 
Published: February 2024

Abstract
LNAPL (Light Non-Aqueous Phase Liquid) contamination has consistently attracted attention, and understanding its migration characteristics can provide valuable insights for remediating soil pollution.This study employs a combination of Electrical Resistivity Tomography (ERT) and direct observation to investigate the migration mechanisms and rates of LNAPL under three conditions: unsaturated media, constant groundwater level, and declining groundwater level.The findings indicate that groundwater is a crucial factor influencing the migration of LNAPL.Under unsaturated media conditions, the initial migration rate is the fastest. In the presence of a constant water level, the average migration rate is the slowest, exhibiting a linear decreasing trend. The migration is fastest during declining groundwater levels, and under the influence of three-phase coupling, LNAPL migration rates oscillate.The use of ERT can meet the observational accuracy at the laboratory scale, enabling the visualization of the migration process of LNAPL within the subsurface medium.
Analysis of Solutions for a Class of (p1(x), ..., pn(x))-Laplacian Systems with Hardy potentials
Authors: Hamdani Mohamed Karim , Kefi Khaled , Liu Jian 
Published: February 2024

Abstract
In this current work, we examine a (p1(x), ..., pn(x))-Laplacian system with Hardy potentials. We establish the existence of at least one non-zero critical point and at least three distinct critical points to this system from an abstract critical point result of Bonanno-Candito-D’Agu´ı [Adv. Nonlinear Stud. 14 (4), 915-939 (2014)] and a recent three critical points theorem of Bonanno-Marano [Appl. Anal. 89 1-10 (2010)]. This article represents, as far as we are aware, one of the first efforts towards the study of the (p1(x), ..., pn(x))-Laplacian systems with Hardy potentials, in which the nonlinearity in Ω may change sign. Furthermore, we provide an example to illustrate our main conclusions.