bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower extremity joint contact force symmetry during walking and running, 2–7 years post‐ACL reconstruction
Authors: Padhye Ankur Anand , Meardon Stacey A. , Kulas Anthony , Willson John 
Published: December 2023

AbstractPremature osteoarthritis after anterior cruciate ligament reconstruction (ACLR) is common among athletes. Reduced knee contact forces after ACLR likely contribute to the multifactorial etiology of the disease. Whether this reduction is accompanied by compensatory increases in joint contact forces (JCF) at adjacent or contralateral joints is unclear. It is also unclear if compensatory effects depend on the task demands. Thus, we compared hip, knee, and ankle JCF symmetry between individuals with reconstruction and a matched control group during walking and running. Thirty participants (19 females), 2–7 years post‐unilateral ACLR (mean = 47.8 months), and 30 controls matched on sex, mass, and activity level were recruited. Limb symmetry indices of peak contact forces and force impulses were calculated for each joint during walking and running, and analyzed using two‐factor (group, activity) analysis of variances. Lower ACLR group peak knee JCF (p = 0.009) and knee JCF impulse (p = 0.034) during walking and running were observed. An interaction of group and activity was observed for peak hip JCF, with ACLR participants demonstrating greater involved limb peak hip JCF during running (p = 0.012). Ankle JCF and ground reaction force symmetry indices were not different between groups or across tasks. Decreased knee and increased ipsilateral peak hip JCF during running suggests that proximal adaptations exist at 2–7 years after ACLR, particularly during activities with increased task demand. Clinical significance: Knee and hip JCF asymmetry at 2–7 years after ACLR may underscore a need for clinical strategies and follow‐up assessments to identify and target such outcomes.
Lipolysis products from triglyceride‐rich lipoproteins induce stress protein ATF3 in osteoblasts
Authors: Rutkowsky Jennifer M. , Wong Alice , Toupadakis Chrisoula A. , Rutledge John C. , Yellowley Clare E. 
Published: December 2023

AbstractHigh fat diets overwhelm the physiological mechanisms for absorption, storage, and utilization of triglycerides (TG); consequently TG, TG‐rich lipoproteins (TGRL), and TGRL remnants accumulate, circulate systemically, producing dyslipidemia. This associates with, or is causative for increased atherosclerotic cardiovascular risk, ischemic stroke, fatty liver disease, and pancreatitis. TGRL hydrolysis by endothelial surface‐bound lipoprotein lipase (LPL) generates metabolites like free fatty acids which have proinflammatory properties. While osteoblasts utilize fatty acids as an energy source, dyslipidemia is associated with negative effects on the skeleton. In this study we investigated the effects of TGRL lipolysis products (TGRL‐LP) on expression of a stress responsive transcription factor, termed activating transcription factor 3 (ATF3), reactive oxygen species (ROS), ATF3 target genes, and angiopoietin‐like 4 (Angptl4) in osteoblasts. As ATF3 negatively associates with osteoblast differentiation, we also investigated the skeletal effects of global ATF3 deletion in mice. TGRL‐LP increased expression of Atf3, proinflammatory proteins Ptgs2 and IL‐6, and induced ROS in MC3T3‐E1 osteoblastic cells. Angptl4 is an endogenous inhibitor of LPL which was transcriptionally induced by TGRL‐LP, while recombinant Angptl4 prevented TG‐driven Atf3 induction. Atf3 global knockout male mice demonstrated increased trabecular and cortical microarchitectural parameters. In summary, we find that TGRL‐LP induce osteoblastic cell stress as evidenced by expression of ATF3, which may contribute to the negative impact of dyslipidemia in the skeleton. Further, concomitant induction of Angptl4 in osteoblasts might play a protective role by reducing local lipolysis.
Construction and validation of a novel NAD+ metabolism‐related risk model for prognostic prediction in osteosarcoma
Authors: Yu Ronghui , Lu Gang , Cheng Banghong , Li Junhong , Jiang Qiqing , Lan Xia 
Published: December 2023

AbstractCurrently, the prognosis of osteosarcoma (OS) remains discouraging, especially in elderly/metastatic OS patients. By impairing the antitumor effect of immune cells, tumor immune microenvironment (TIME) provides an environment conducive to tumor proliferation, which highly requires accelerated nicotinamide adenine dinucleotide (NAD+) metabolism for energy. Recently, many genes involved in the sustained production of NAD+ in malignant tumors have been verified to be possible prognostic indicators and therapeutic targets. Therefore, the current study was to probe into the association of NAD+ metabolism‐related genes with TIME, immunotherapeutic response, and prognosis in OS. All OS data for the study were acquired from TARGET and GEO databases. In bioinformatics analysis, we performed Cox analysis, consensus clustering, principal component analysis, t‐distributed stochastic neighbor embedding, uniform manifold approximation and projection, gene set enrichment analysis, gene set variation analysis, Lasso analysis, survival and ROC curves, nomogram, immune‐related analysis, drug sensitivity analysis, and single‐cell RNA sequencing (scRNA‐seq) analysis. Cell transfection assay, RT‐qPCR, western blot analysis, as well as cell wound healing, migration, and invasion assays were performed in vitro. Bioinformatics analysis identified A&B clusters and six NAD+ metabolism‐related differentially expressed genes, constructed risk model and nomogram, and performed immune‐related analysis, drug susceptibility analysis, and scRNA‐seq analysis to inform the clinical treatment framework. In vitro experiment revealed that CBS and INPP1 can promote migration, proliferation as well as invasion of OS cells through TGF‐β1/Smad2/3 pathway. Based on bioinformatics analysis and in vitro validation, this study confirmed that NAD+ metabolism affects TIME to suggest the prognosis of OS.
2023 Radiation oncology highlights
Authors: Salerno Kilian E. , Das Prajnan , Yu James B. 
Published: December 2023

AbstractRadiation oncology plays an important role in the local treatment of cancers. Understanding recent advances in the application of radiation therapy to solid tumors is important for all disciplines. The radiation oncology section editors for this journal have selected the following articles for their overall significance, relevance to surgical oncologists, and to illustrate important concepts within the practice of radiation oncology.
Research on the diffusion of green innovation behavior based on complex network evolutionary game
Authors: Chen Xiaoya , Yang Weiwei , Zhang Renjie 
Published: December 2023

AbstractThe strategic choice of green innovation subjects and the evolution of green innovation networks have a two‐way feedback effect. This study aims to construct a comprehensive framework for analyzing the evolution of green innovation networks from micro to macro levels. The gravity model demonstrates the structural complexity of green innovation networks. Additionally, an evolutionary game model based on green innovation networks is constructed to discuss the network's diffusion mechanism of green innovation behavior and its influence on network characteristic indicators. The research findings reveal that (1) the green innovation networks in China exhibit a continuous growth trend but the connectivity of urban nodes varies significantly; (2) the green innovation network's marginal nodes are the “vulnerable groups” in the evolutionary game and the active green innovation strategy cannot be completely spread; and (3) the cost of passive green innovation and the demand for green consumption are the internal and external driving forces that promote the spread of the active green innovation strategy in the network. Finally, this study concludes with several suggestions, including the establishment of a mechanism to promote green innovation reform with the city, industry, and enterprises as the node, fulcrum, and focus, respectively. Additionally, it suggests increasing domestic demand for green consumption. These findings and suggestions can provide a reference for the development of green innovation in other countries or regions.
Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction
Authors: Schramm Georg , Filipovic Marina , Qian Yongxian , Alivar Alaleh , Lui Yvonne W. , Nuyts Johan , Boada Fernando 
Published: December 2023

AbstractPurposeSodium MRI is challenging because of the low tissue concentration of the23Na nucleus and its extremely fast biexponential transverse relaxation rate. In this article, we present an iterative reconstruction framework using dual‐echo23Na data and exploiting anatomical prior information (AGR) from high‐resolution, low‐noise,1H MR images. This framework enables the estimation and modeling of the spatially varying signal decay due to transverse relaxation during readout (AGRdm), which leads to images of better resolution and reduced noise resulting in improved quantification of the reconstructed23Na images.MethodsThe proposed framework was evaluated using reconstructions of 30 noise realizations of realistic simulations of dual echo twisted projection imaging (TPI)23Na data. Moreover, three dual echo23Na TPI brain datasets of healthy controls acquired on a 3T Siemens Prisma system were reconstructed using conventional reconstruction, AGR and AGRdm.ResultsOur simulations show that compared to conventional reconstructions, AGR and AGRdm show improved bias‐noise characteristics in several regions of the brain. Moreover, AGR and AGRdm images show more anatomical detail and less noise in the reconstructions of the experimental data sets. Compared to AGR and the conventional reconstruction, AGRdm shows higher contrast in the sodium concentration ratio between gray and white matter and between gray matter and the brain stem.ConclusionAGR and AGRdm generate23Na images with high resolution, high levels of anatomical detail, and low levels of noise, potentially enabling high‐quality23Na MR imaging at 3T.
Can we improve techniques and patients' selection for nerve stimulation suitable for lower urinary tract dysfunctions? ICI‐RS 2023
Authors: Mancini Vito , Damaser Margot S. , Chermansky Christopher , Ochoa Carolina D. , Hashim Hashim , Przydacz Mikolaj , Hervé François , Martino Leonardo , Abrams Paul 
Published: December 2023

AbstractAimsLower urinary tract dysfunctions (LUTD) are very common and, importantly, affect patients' quality of life (QoL). LUTD can range from urinary retention to urgency incontinence and includes a variety of symptoms. Nerve stimulation (NS) is an accepted widespread treatment with documented success for LUTD and is used widely. The aim of this review is to report the results of the discussion about how to improve the outcomes of NS for LUTD treatment.MethodsDuring its 2023 meeting in Bristol, the International Consultation on Incontinence Research Society discussed a literature review, and there was an expert consensus discussion focused on the emerging awareness of NS suitable for LUTD.ResultsThe consensus discussed how to improve techniques and patients' selection in NS, and high‐priority research questions were identified.ConclusionsTechnique improvement, device programming, and patient selection are the goals of the current approach to NS. The conditional nerve stimulation with minimally invasive wireless systems and tailored algorithms hold promise for improving NS for LUTD, particularly for patients with neurogenic bladder who represent the new extended population to be treated.
Tunable tension tape versus transobturator tape in treatment of stress urinary incontinence in women: Randomized controlled trial
Authors: Kubin Nikita , Shakhaliev Rustam , Labetov Ivan , Kovalev Gleb , Shulgin Andrei , Nuriev Alexey , Shkarupa Dmitry 
Published: December 2023

AbstractIntroductionThe synthetic mid‐urethral slings are currently considered to be the most widely used technique for the surgical treatment of stress urinary incontinence (SUI). The most challenging aspect of the existing approaches is to achieve the optimal tension of the sling which treatment results are directly dependent on. To solve this problem, sling systems enabling an adjustment of the tension in the early postoperative period were created. A comparative study of the effectiveness and safety of such a system and a nonadjustable sling seems to be a relevant task.Materials and MethodsA double‐blind, randomized, multicenter trial enrolled 320 patients with a mean age of 55.2 ± 11.2 years and confirmed SUI. Patients were randomized into two groups: the first group underwent a standard synthetic suburethral sling (transobturator tape [TOT]) procedure and the second group underwent a tunable tension tape sling (TTT) procedure. All patients underwent stress test, uroflowmetry and ultrasound scan to determine the postvoid residual volume. Urinary Distress Inventory Short Form 6, International Consultation on Incontinence Questionnaire—Short Form, Pelvic Organ Prolapse Incontinence Sexual Questionnaire 12 questionnaires were used to assess subjective efficacy.ResultsEnhancement of prosthesis tension in the second group was required in 44 (28%) patients. Due to the possibility of tightening of the sling in the early postoperative period, the operation was effective in 143 (89%) patients in the adjustable sling group and in 109 (68%) patients in Group 1, p < 0.001. Loosening of the sling tension was performed in 25 (16%) patients in Group 2. The signs of obstructive voiding symptoms at the follow‐up time of 36 months remained in Group 1 in 13 (8%) patients. Subjective satisfaction with treatment on the PGI‐I scale was higher in Group 2: 100 (62%) versus 132 (82%), p < 0.001.ConclusionA synthetic mid‐urethral TTT is superior to a standard nonadjustable sling in long‐term effectiveness and safety.
Low Bone Mineral Density and the Risk of Benign Paroxysmal Positional Vertigo
Authors: Li Junhong , Yu Libo , An Ping , Pang Wendu , Yan Xiaohong , Deng Di , Song Yao , Mao Minzi , Qiu Ke , Rao Yufang , Cheng Danni , Zhang Yuyang , Feng Lan , Wang Xiaoyu , Zhang Ziyan , Zheng Yongbo , Xu Wei , Ren Jianjun , Zhao Yu 
Published: December 2023

AbstractObjectiveThis study aimed to comprehensively analyze the relationship between low bone mineral density (BMD) and the risk of benign paroxysmal positional vertigo (BPPV) based on the large prospective population‐based UK Biobank (UKB) cohort.Study DesignProspective population‐based cohort study.SettingThe UKB.MethodsThis prospective cohort study included UKB participants recruited between 2006 and 2010 who had information on BMD and did not have BPPV before being diagnosed with low BMD. Univariable and multivariable logistic regression models were constructed to assess the association between low BMD (overall low BMD, osteopenia, and osteoporosis) and BPPV. We further conducted sex and age subgroup analysis, respectively. Finally, the effects of antiosteoporosis and female sex hormone medications on BPPV in participants with osteoporosis were evaluated.ResultsIn total, 484,303 participants were included in the final analysis, and 985 developed BPPV after a maximum follow‐up period of 15 years. Osteoporosis was associated with a higher risk of BPPV (odds ratio [OR] = 1.37, P = .0094), whereas osteopenia was not. Subgroup analyses suggested that the association between osteoporosis and BPPV was significant only in elderly females (≥60 years, OR = 1.51, P = .0007). However, no association was observed between antiosteoporosis or female sex hormone medications and BPPV in the participants with osteoporosis.ConclusionOsteoporosis was associated with a higher risk of developing general BPPV, especially in females aged ≥ 60 years old, whereas osteopenia was not associated with BPPV.
Medicaid generosity and food hardship among children
Authors: Moellman Nicholas , Vaughn Cody N. 
Published: December 2023

AbstractWe explore the role of the largest means‐tested transfer program, Medicaid, on multiple measures of food hardship among households with children, including measures that capture hardship explicitly experienced by children. Using data from the 2001 to 2020 waves of the December Current Population Survey, we identify the effect of having a Medicaid‐eligible child on household food hardship by exploiting between‐state, over‐time, and between‐household income eligibility criteria. We find that having an eligible child reduces rates of household food insecurity and very low food security by 20% and 26%, respectively. Among children themselves, eligibility reduces rates of food insecurity and very low food security by 22% each. The effects are stronger for households headed by Black and Hispanic individuals as well as households that have children under 6 years old.
Fabrication of solid polymer electrolyte based on carboxymethyl cellulose complexed with lithium acetate salt as Lithium‐ion battery separator
Authors: Darmawan Dhea Afrisa , Yulianti Evi , Sabrina Qolby , Ishida Kensuke , Sakti Aditya Wibawa , Nakai Hiromi , Pramono Edi , Ndruru Sun Theo Constan Lotebulo 
Published: December 2023

AbstractPolymer electrolyte is a crucial component of solid‐state‐lithium‐ion batteries that role both as separators and electrolytes. The host polymer and lithium salt selection are crucial for producing a solid polymer electrolyte with optimum characteristics. This research aims to study the effect of lithium acetate (LiCH3COO) salt on carboxymethyl cellulose (CMC)‐based solid polymer electrolytes. The LiCH3COO‐complexed CMC solid polymer electrolyte was prepared using the solution casting method with various weight percentages of LiCH3COO, that is, 0%wt, 10%wt, 20%wt, and 30%wt. The ionic conductivity analysis was conducted by using electrochemical impedance spectroscopy (EIS), infrared analysis by Fourier transform infra‐red (FTIR), mechanical analysis, crystallinity degree analysis with X‐ray diffraction (XRD), and thermogravimetry analysis (TGA), differential thermogravimetry (DTG), and differential scanning calorimetry (DSC). The interaction between Li+ ions and CMC enhanced ionic conductivity, decreased mechanical strength, reduced crystallinity degree, and lowered thermal properties. The CMC/LiCH3COO (70/30) SPE was selected as the optimum condition because it exhibited good ionic conductivity and sufficient thermal stability, while it needs a mechanical strength improvement. Molecular dynamics simulations were also performed at the density‐functional tight‐binding (DFTB) level to unravel the molecular mechanism of the Li‐ion hopping in CMC. The CMC/LiCH3COO (70/30) showed the highest electrochemical window as high as 3.5 V. Based on the results, CMC complexed with 30 (%wt) LiCH3COO salt showed high potential as a polymer electrolyte for lithium‐ion battery applications.Highlights
Fabrication of solid polymer electrolyte based on carboxymethyl cellulose complexed with lithium acetate salt was conducted by simple casting solution method.
The 30%wt LiCH3COO into carboxymethyl cellulose (CMC)‐polymer host showed the highest ionic conductivity of 2.47 × 10−5 S cm−1.
The 30%wt LiCH3COO‐complexed CMC shows some degradation peaks, they are water evaporation, decomplexation, depolymerization, melting, and completely degraded.
The density‐functional tight‐binding method suggests that the Li‐ions hop both in perpendicular and parallel directions of the cellulose layers.
The CMC/LiCH3COO (70/30) showed the highest electrochemical window as high as 3.5 V.
Current controversies in prenatal diagnosis: Noninvasive prenatal testing should replace other screening strategies for fetal trisomies 13, 18, 21
Authors: Pandya Pranav , Levy Brynn , Sistermans Erik A. 
Published: December 2023

AbstractThis is a written summary of the oral debate presented at the International Society for Prenatal Diagnosis annual conference in Edinburgh in 2023. The topic under debate is whether noninvasive prenatal testing (NIPT) using cell‐free fetal DNA should replace other screening strategies for the detection of fetal trisomies 13, 18, 21. There is no disagreement that NIPT is far more sensitive and has better positive predictive values for identifying trisomies 13, 18, and 21 than traditional screening approaches using biochemical markers and measurement of nuchal translucency. The major issue lies in the potential adverse consequences associated with abandoning traditional screening methods. The source of disagreement stems primarily from whether you consider the role of ultrasound in the context of screening to be strictly for nuchal translucency measurement or whether it should be combined with a fetal anatomy scan. The debate featured two experts who presented evidence in favor of each argument.
Fear of cancer recurrence in ovarian cancer caregivers: A qualitative study
Authors: Webb Kyra , Sharpe Louise , Russell Hayley , Shaw Joanne 
Published: December 2023

AbstractAimAlthough there is growing research exploring survivor fear of cancer recurrence (FCR), little is known about caregiver FCR. To date, examination of caregiver FCR has largely been conducted through the lens of survivor conceptualisations, limiting the development of caregiver‐specific models, measures, and interventions. This study aimed to explore experiences of FCR among caregivers of people with ovarian cancer.MethodsSemi‐structured telephone interviews were conducted with caregivers of people with ovarian cancer. Participants, recruited through Ovarian Cancer Australia, also completed an online survey collecting participant and patient demographic characteristics, information about the survivor's disease and caregiver levels of FCR using the Fear of Cancer Recurrence Inventory (Caregiver) (FCRI‐c). Qualitative interviews explored caregiver fears, how fears and concerns were experienced and the frequency and timing of FCR. Thematic analysis using a Framework Approach was used to analyse the results.ResultsTwenty‐four caregivers (54% male) participated in an interview. Most caregivers were providing care for their partner (n = 14). Thematic analysis identified four inter‐related themes and associated sub‐themes: (1) Fear and uncertainty; (2) Liminality; (3) Hopelessness and (4) Caregiver's protection of the person and self (caregiver's role as protector). Underpinning these themes was an overarching fear of one's family member dying.ConclusionsCaregivers supporting people with ovarian cancer experience worries and concerns related to cancer recurrence or progression. These experiences are conceptually different to survivor experiences. Fear of one's family member dying, and the dual nature of caregiver protection/self‐protection mean it is imperative that interventions are tailored specifically to caregiver needs. Future research facilitating the development of appropriate measures and interventions is essential to reduce caregiver FCR.