bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between psychological distress and mental help-seeking intentions in international students of national university of Singapore: a mediation analysis of mental health literacy
Authors: Zeng Fanmin , John Wong Chee Meng , Qiao Dan , Sun Xueli 
Published: November 2023

Abstract
Background
International students encounter a wide range of challenges that can have a significant impact on their mental health. Seeking help is one of the primary means of managing mental health, and more attention is required. This study aimed to investigate the psychological distress(PD), mental health literacy(MHL), and mental help-seeking intentions(MHSI) in international students of National University of Singapore(NUS), to explore the correlation between the three and to verify the mediating role of MHL in PD and MHSI.

Methods
This cross-sectional study was conducted between May and July 2023 using the Mental Help Seeking Intention Scale(MHSIS), Patient Health Questionnaire-9(PHQ-9), Generalized Anxiety Disorder-7(GAD-7), and Mental Health Literacy Scale(MHLS). 281 international students(177 males, 104 females;) in NUS completed self-report questionnaires. SPSS 25.0 was applied to the data for descriptive analysis, Pearson correlation analysis and stepwise regression analysis. Mediation analysis fully for all potential confounding factors were conducted.

Results
Significant correlations were found between PD, MHL and MHSI. MHLS- knowledge of how to seek professional information(MHLS- H) completely mediated the association of anxiety with MHSI[B=-0.271; 95% confidence interval(CI): (-0.067, 0.0037)]; MHLS- attitude that promote recognition or appropriate help-seeking behavior(stigma)(MHLS- H) partially mediated the association of PD with MHSI[B = 0.104, 95% CI: (0.008, 0.179)]; with mediating effects accounting for 100% and 24.847% of the total effect. In addition, demographic variables such as gender, years in Singapore and residence type mediated both the direct and indirect effect of the mediation model.

Conclusions
MHL mediated both the direct and indirect effects on the association between PD and MHSI, especially, the mediator of the MHLS- H and MHL-A. It means that MHSI in this population can be improved by increasing MHL and thus the PD. The findings suggest that, such as providing information about how to access to professional services and promoting disorder recognition to the international students, may help them develop their psychological well-being and good mental health care decisions.
Efficacy of the transcutaneous electrostimulation in treatment dysfunctions of the TMJ associated with occlusion distortions
Authors: Khachatryan Zhanna , Hambartsoumian Tsovinar , Tatintsyan Lyudmila , Burnazyan Seda , Hakobyan Gagik 
Published: November 2023

Abstract
Background
The study evaluation of the effectiveness the method of electrostimulation in treatment TMJ associated with occlusion disorders with the use of a patches by the company “Aganyan’’.

Methods
The study included 54 patients with temporomandibular dysfunction syndrome who had previously undergone endodontic dental treatment. In patients temporomandibular disorders (TMD) determined on the basis of Diagnostic criteria for temporomandibular disorders(DC/TMD).All patients had occlusion disorders due to errors after dental filling restoration. To diagnose the TMJ, a CT scan was used. The complex therapy also included therapy and with the use of a patches by the company “Aganyan’’. The wearable patch includes a flexible substrate, a binder an adhesive layer, with an electrode foil attached to it. Patients applied one patch behind each TMJ. The patches were applied for eight hours every third day for three months. All the patients were given full-fledged endodontic treatment and restoration of the crown part, taking into account anatomical features.

Results
The dynamics of the complex treatment of patients diagnosed with TMJ dysfunction syndrome showed that after treatment, the clinical symptoms gradually decreased and disappeared at the end of treatment. CT scan a year after treatment showed a normal ratio of TMJ elements. Сomplex treatment was effective in 87% of patients, after 3–5 months gradually decreased pain, noise in the joints, restriction of opening and closing of the mouth disappeared. Patients recovered their chewing functions, psycho-emotional state.

Conclusion
The results of the studies revealed a positive effects for the complex treatment dysfunctions syndrome TMJ the using the patches by the company “Aganyan” through electrical stimulation with low intensity.
Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection
Authors: Alajmi Fatemah , Al-Otaibi Tahani , Al-Quraishy Saleh , Al-Shaebi Esam M. , Al-Hoshani Nawal , Dkhil Mohamed A. , Abdel-Gaber Rewaida 
Published: November 2023

AbstractCoccidiosis is the most prevalent disease-causing widespread economic loss among farm and domestic animals. Currently, several drugs are available for the control of this disease but resistance has been confirmed for all of them. There is an urgent need, therefore, for the identification of new sources as alternative treatments to control coccidiosis. The present work aimed to study the effect of thePersea americanaextract (PAE) as an anti-coccidial, anti-oxidant, and anti-apoptotic modulator during murine intestinalEimeria papillatainfection. A total of 25 male mice were divided into five groups, as follows:Group1: Non-infected-non-treated (negative control),Group2: Non-infected-treated group with PAE (500 mg/kg b.w).Group3: Infected-non-treated (positive control),Group4: Infected-treated group with PAE (500 mg/kg b.w.), andGroup5: Infected-treated group with Amprolium (120 mg/kg b.w.). Groups (3–5) were orally inoculated with 1 × 103sporulatedE. papillataoocysts. After 60 min of infection, groups (4 and 5) were treated for 5 consecutive days with the recommended doses of PAE and amprolium. The fact that PAE has an anti-coccidial efficacy against intestinalE. papillatainfection in mice has been clarified by the reduction of fecal oocyst output on the 5thday post-infection by about 85.41%. Moreover, there is a significant reduction in the size of each parasite stage in the jejunal tissues of the infected-treated group with PAE. PAE counteracted theE. papillata-induced loss of glutathione peroxidase (GPx), superoxide dismutase (SOD), and total antioxidant capacity (TCA).E. papillatainfection also induced an increase in the apoptotic cells expressed by caspase-3 which modulated after PAE treatment. Moreover, the mRNA expression of the goblet cell response gene, mucin (MUC2), was upregulated from 0.50 to 1.20-fold after treatment with PAE. Based on our results, PAE is a promising medicinal plant with anti-coccidial, anti-oxidant, and anti-apoptotic activities and could be used as a food additive.
RETRACTED ARTICLE: A novel necroptosis signature for predicting survival in lung adenocarcinoma
Authors: Zang Kui , Wang Min , Zhu Xingxing , Yao Bin , Huang Ying 
Published: November 2023

Abstract
Background
To explore the necroptosis-related genes (NRGs) signature and its
predictive values in lung adenocarcinoma (LUAD).

Methods
The training cohort consisted of tumor samples from The Cancer
Genome Atlas, and the validation set comprised data from the Gene Expression
Omnibus. Univariate and multivariate Cox regression analyses were applied to
identify the prognostic NRG signature as an independent molecular indicator.
Correlation analysis was used for the association assessment between the NRG
signature and immune checkpoint molecules.

Results
NRGs involved in necroptosis and immune NOD-like receptor signaling.
The NRG signature based on eight NRGs can divide tumors into high-risk and
low-risk groups, which was significantly associated with worse survival.
Multivariate Cox regression analysis showed that this NRG signature remained an
independent prognostic indicator. Stratification analyses demonstrated that this
NRG signature was still effective for predicting survival in each stratum of
age, gender, and tumor stage. The ROC curve showed a good predictive ability
using the NRG signature in the validation cohort (AUC = 0.81). The
NRG signature was related to immune checkpoint molecules
PD − 1, PD-L1, and PD-L2.

Conclusions
The NRG signature could be a novel predictor of the prognosis and
may become a potential therapeutic target in LUAD.
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Authors: Chen Bin , Liu Ziyi , Lu Jinjuan , Li Zhihao , Kuang Kaiming , Yang Jiancheng , Wang Zengmao , Sun Yingli , Du Bo , Qi Lin , Li Ming 
Published: November 2023

Abstract
Objectives
Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM from inspiratory chest CT scans can effectively evaluate SAD in individuals with normal spirometry.

Methods
We included 537 participants with normal spirometry, a history of smoking or secondhand smoke exposure, and divided them into training, tuning, and test sets. A cascaded generative adversarial network generated expiratory CT from inspiratory CT, followed by a UNet-like network predicting PRM using real inspiratory CT and generated expiratory CT. The performance of the prediction is evaluated using SSIM, RMSE and dice coefficients. Pearson correlation evaluated the correlation between predicted and ground truth PRM. ROC curves evaluated predicted PRMfSAD (the volume percentage of functional small airway disease, fSAD) performance in stratifying SAD.

Results
Our method can generate expiratory CT of good quality (SSIM 0.86, RMSE 80.13 HU). The predicted PRM dice coefficients for normal lung, emphysema, and fSAD regions are 0.85, 0.63, and 0.51, respectively. The volume percentages of emphysema and fSAD showed good correlation between predicted and ground truth PRM (|r| were 0.97 and 0.64, respectively, p < 0.05). Predicted PRMfSAD showed good SAD stratification performance with ground truth PRMfSAD at thresholds of 15%, 20% and 25% (AUCs were 0.84, 0.78, and 0.84, respectively, p < 0.001).

Conclusion
Our deep learning method generates high-quality PRM using inspiratory chest CT and effectively stratifies SAD in individuals with normal spirometry.
Effects of dapagliflozin and dapagliflozin-saxagliptin on erythropoiesis, iron and inflammation markers in patients with type 2 diabetes and chronic kidney disease: data from the DELIGHT trial
Authors: Koshino Akihiko , Neuen Brendon L. , Jongs Niels , Pollock Carol , Greasley Peter J. , Andersson Eva-Marie , Hammarstedt Ann , Karlsson Cecilia , Langkilde Anna Maria , Wada Takashi , Heerspink Hiddo J.L. 
Published: November 2023

Abstract
Background
This post-hoc analysis of the DELIGHT trial assessed effects of the SGLT2 inhibitor dapagliflozin on iron metabolism and markers of inflammation.

Methods
Patients with type 2 diabetes and albuminuria were randomized to dapagliflozin, dapagliflozin and saxagliptin, or placebo. We measured hemoglobin, iron markers (serum iron, transferrin saturation, and ferritin), plasma erythropoietin, and inflammatory markers (urinary MCP-1 and urinary/serum IL-6) at baseline and week 24.

Results
360/461 (78.1%) participants had available biosamples. Dapagliflozin and dapagliflozin-saxagliptin, compared to placebo, increased hemoglobin by 5.7 g/L (95%CI 4.0, 7.3; p < 0.001) and 4.4 g/L (2.7, 6.0; p < 0.001) and reduced ferritin by 18.6% (8.7, 27.5; p < 0.001) and 18.4% (8.7, 27.1; p < 0.001), respectively. Dapagliflozin reduced urinary MCP-1/Cr by 29.0% (14.6, 41.0; p < 0.001) and urinary IL-6/Cr by 26.6% (9.1, 40.7; p = 0.005) with no changes in other markers.

Conclusions
Dapagliflozin increased hemoglobin and reduced ferritin and urinary markers of inflammation, suggesting potentially important effects on iron metabolism and inflammation.

Trial registration
ClinicalTrials.gov NCT02547935.
Bystander preference for naloxone products: a field experiment
Authors: Marks Katherine R. , Oyler Douglas R. , Strickland Justin C. , Jaggers Jody , Roberts Monica F. , Miracle Dustin K. , Barnes Chase , Lei Feitong , Smith Amanda , Mackin Eric , Martin Martika C. , Freeman Patricia R. 
Published: November 2023

Abstract
Background
Bystander administration of naloxone is a critical strategy to mitigate opioid overdose mortality. To ensure bystanders’ willingness to carry and administer naloxone in response to a suspected overdose, it is critical to select products for community distribution with the highest likelihood of being utilized. This study examines bystanders’ preference for and willingness to administer three naloxone products approved by the FDA for bystander use and identify product features driving preference.

Methods
The population was a convenience sample of individuals who attended the Kentucky State Fair, August 18–28, 2022, in Louisville, Kentucky. Participants (n = 503) watched a standardized overdose education and naloxone training video, rated their willingness to administer each of three products (i.e., higher-dose nasal spray, lower-dose nasal spray, intramuscular injection), selected a product to take home, and rated factors affecting choice.

Results
After training, 44.4% chose the higher-dose nasal spray, 30.1% chose the intramuscular injection, and 25.5% chose the lower-dose nasal spray. Factors most influencing choice on a 10-point Likert scale were ease of use (9 [7–10]), naloxone dose (8 [5–10]), and product familiarity (5 [5–9]).

Conclusions
Bystanders expressed high willingness to administer all studied formulations of naloxone products. Product choice preference varied as a function of product features. As the number and variety of available products continue to increase, continuous evaluation of formulation acceptability, in addition to including individuals with lived experience who are receiving and administering overdose reversal agents, is critical to support adoption and save lives.
Outcomes of Ponte osteotomy combined with posterior lumbar interbody fusion for reconstruction of coronal and sagittal balance in degenerative scoliosis
Authors: Zhang Haoran , Du You , Zhao Yiwei , Yang Yang , Zhang Jianguo , Wang Shengru 
Published: November 2023

Abstract
Purpose
The purpose of the study was to evaluate the clinical efficacy and safety of using Ponte osteotomy combined with posterior lumbar interbody fusion in the treatment of patients with degenerative scoliosis.

Method
The medical records and imaging data of degenerative scoliosis patients in our department from 2013 to 2022 were retrospectively collected. A total of 47 patients were included, including 16 male patients and 31 female patients. The mean follow-up was 47.8 months. Whole spine X-rays in the standing position were performed on all patients preoperatively, postoperatively, and at the latest follow-up. The length of hospital stay, complications, operative duration, estimated blood loss, instrumented segment, fused segment, clinical scores, and various radiological indicators were recorded.

Results
The coronal vertical axis improved from 3.1 ± 1.9 cm preoperatively to 1.2 ± 1.0 cm postoperatively with an average reduction of 1.9 ± 1.7 cm. The preoperative coronal Cobb angle was 18.1 ± 10.6°, the immediate postoperative Cobb angle was 6.6 ± 3.9°, and the Cobb angle at the last follow-up was 5.8 ± 3.7°. The sagittal vertical axis decreased from 5.6 ± 3.7 cm preoperatively to 2.7 ± 1.9 cm immediately after the operation and was well maintained at the last follow-up (3.1 ± 2.5 cm). Lumbar lordosis increased from 22.2 ± 10.2° preoperatively to 40.4 ± 8.3° postoperatively and 36.0 ± 8.8° at the last follow-up. The ODI score, VAS low back pain score, and VAS leg pain score were also improved to varying degrees.

Conclusion
Ponte osteotomy combined with posterior lumbar interbody fusion can significantly improve coronal and sagittal plane deformities and postoperative functional scores in patients with adult degenerative scoliosis.
Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia
Authors: Chen Qi , Xu QingYang , Zhu Huilin , Wang Junyi , Sun Ning , Bian Huimin , Li Yu , Lin Chao 
Published: November 2023

Abstract
Background
Myocardial ischemia (MI) can cause angina, myocardial infarction, and even death. Angiogenesis is beneficial for ensuring oxygen and blood supply to ischemic tissue, promoting tissue repair, and reducing cell damage. In this study, we evaluated the effects of Salvianolic acid B (Sal B) against myocardial ischemia and explored its underlying mechanism on autophagy.

Methods
The anti-apoptosis effect of Sal B was conducted by staining Annexin V-FITC/PI and Hoechst as well as evaluating apoptosis bio-markers at protein level in H9c2 cells at glucose deprivation condition. HUVECs were co-cultured with H9c2, and the tube formation assay was used to monitor Sal B’s impact on angiogenesis. The MI model of mice was induced by intraperitoneal injection of isoproterenol (ISO). The effect of Sal B on MI mice was evaluated by HE, Masson, immunohistochemistry, WB and kits. In addition, Atg5 siRNA was applied to verify whether the protective effect of Sal B was regulated to autophagy.

Results
In H9c2, Sal B reduced the levels of lactate dehydrogenase (LDH), malondialdehyde (MDA) and reactive oxygen species (ROS), improved the levels of superoxide dismutase (SOD) and mitochondrial membrane potential, downregulated the expressions of Bax and cleaved-Caspase3, upregulated the expression of Bcl-2. Therefore, Sal B could significantly inhibit the damage of H9c2 caused by glucose deprivation. In the co-culture system of H9c2 and HUVECs, vascular endothelial growth factor (VEGF) level in the supernatant was dramatically raised by Sal B. Sal B upregulated the expressions of VEGF, platelet derived growth factor (PDGF) and endothelial marker CD31. It implied that Sal B exerted a significant pro-angiogenic effect. Moreover, Sal B increased the expression of LC3, Atg5, and Beclin1, while reducing the level of P62. When the expression of Atg5 was inhibited, the protective effects of Sal B on apoptosis and angiogenesis was reversed.

Conclusions
Sal B inhibited cardiomyocyte apoptosis and promoted angiogenesis by regulating autophagy, thereby improving MI.
Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients
Authors: Yang Yi , Song An , Gong Fengying , Jiang Yan , Li Mei , Xia Weibo , Xing Xiaoping , Wang Ou , Pan Hui 
Published: November 2023

Abstract
Background
Pseudohypoparathyroidism type 1 (PHP1) is a rare disease featuring hypocalcemia and elevated PTH level. Though disturbed calcium and phosphorus metabolism under PTH resistant have been widely studied, glucolipid metabolism abnormalities observed in PHP1 patients have received little attention. The aim of this research is to explore the glucolipid metabolism features in a rather large cohort of PHP1 patient. In the current study, PHP1 patients and primary hyperparathyroidism patients as well as normal control were recruited for the investigation. Glucolipid metabolic indices as well as the level of four adipokines were examined.

Results
A total of 49 PHP1 patients, 64 PHPT patients and 30 healthy volunteers were enrolled. A trend of higher HOMA-β index was found in PHP1 patients than normal controls (median 97.08% vs 68.19%, p = 0.060). Both the PHP1 and PHPT group presented with significantly lower TNFα level compared to normal controls (average 10.74 pg/ml and 12.53 pg/ml vs 15.47 pg/ml, p = 0.002 and 0.041, respectively). FGF21 level was significantly higher in PHPT group than in PHP1 group (median 255.74 pg/ml vs 167.46 pg/ml, p = 0.019). No significant difference in glucolipid metabolic indices and adipokines was found between PHP1A or PHP1B patients and normal controls, while overweight/obese PHP1 patients tended to have higher leptin than normal-BMI cases (p = 0.055). Multiple linear regression analysis showed BMI rather than PTH or HOMA-IR to be an independent variable of leptin in PHP1.

Conclusion
Metabolic stress given upon especially overweight PHP1 patients may resulted in possible β-cell compensation. Elevated TNFα may be related with hyper-PTH level regardless of calcium level.
Transitioning to adult mental health services for young people with ADHD: an Italian-based survey on practices for pediatric and adult services
Authors: Roberti Elisa , Scarpellini Francesca , Campi Rita , Giardino Michele , Clavenna Antonio , Bonati Maurizio ,   the TransiDEA group, Stoppa Patrizia , Martinelli Ottaviano , Morosini Paola , Capovilla Giuseppe , Costantino Maria Antonella , Raviglione Federico , Conti Patrizia , Rossi Giorgio , Giarelli Maria Teresa , Fazzi Elisa Maria , Carpanelli Marialuisa , Canevini Maria Paola , Rinaldi Francesco , Molteni Massimo , Vignoli Aglaia , Borgatti Renato , Farinotti Laura , Arcangeli Donatella , Bona Paola , Giovannoni Franco , Pincherle Maurizio , Canitano Roberto , Gennaro Elena , Caucci Chiara , Bravaccio Carmela , Sotgiu Stefano , Costanza Giancarlo , Briatore Eleonora , Vitiello Benedetto , Zappulla Giuseppe , Colombi Elisa , Ferrario Mariarosa , Franzoi Malida , Martinez Federica , Obino Laure , Carrozzi Marco , Durbano Federico , Grignani Marco , Grignani Marco , Antonucci Alessandro , Rella Angelo , Di Paolo Pietro , Fiore Germano , Piemontese Gianluca , De Nicola Giulio , Conca Andres , Cucciniello Angelo , Rosa Moro Anna , Francobandiera Giorgio , Moraca Maria Carla , Corsini Paola , Antonucci Alessandro , Bondi Emi , Aroasio Luisa , Imperadore Giuseppe , Malagamba Daniela , Callegari Camilla , Toscano Marco , Di Cesare Gialuigi , Cappa Corrado , Gardellin Francesco , Laudani Elio , Raschitelli Nicoletta , Zanetti Michele , Cartabia Massimo , Graziani Vanna , Marchetti Federico , Suprani Tosca , Di Bartolo Paolo , Viganò Ilaria , Costantino Ilaria , Tessarollo Valeria , Ruffoni Giampaolo 
Published: November 2023

Abstract
Background
Supporting young ADHD patients in transition to adult services is essential. Yet, the low percentages of successful referrals and the issues reported by patients and clinicians stress the need for further attention to transitioning practices. The present study assessed the transitioning process of Attention-Deficit/Hyperactivity Disorder (ADHD) patients in Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Italian territory. We asked child and adult psychiatrists to report the current state of services and their observations on limitations and possible future matters that must be addressed.

Method
Seventy-seven centers (42 CAMHS, 35 AMHS) filled in a web-based survey in which they reported the number of ADHD patients, how many transitioning patients they had within the past year, and how they structured transition.

Results
A fragmented picture emerged from the survey. Lack of resources, training, and communication between services hinder the transition process, and many adult patients remain under CAMHS’ care. While some services have a protocol, there is no structured guidance that can help improve integration and continuity of treatment.

Conclusion
The observed situation reflects a need for improvement and standard guidelines to enable a successful transition process, considering clinicians' and patients’ necessities.