bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of pharmacist-led intervention for reducing drug-related problems and improving quality of life among chronic kidney disease patients: A randomized controlled trial
Authors: Zafar Roheena , Rehman Inayat Ur , Shah Yasar , Ming Long Chiau , Goh Khang Wen , Suleiman Amal K , Khan Tahir Mehmood 
Published: February 2025

Introduction
Chronic kidney disease (CKD) patients suffer from different comorbid conditions and are prone toward drug-related problems (DRPs) which affect their clinical parameters as well as quality of life (QoL). This study was aimed to evaluate the impact of clinical pharmacist-led interventions on the mean number of DRPs and the mean QoL score difference per patient DRPs in CKD patients.

Method
An open-labeled, randomized control trial performed from April 2023 to July 2023 in the nephrology unit of a tertiary care setting in Peshawar Pakistan. Those patients who met the inclusion criteria were randomized into two groups 1:1, i.e., control and intervention group. Clinical pharmacists identified the DRPs at baseline using Pharmaceutical Care Network Europe (PCNE) 9.1 guidelines. The QoL of patients were assessed at baseline and endpoint by using the Functional Assessment of Non-Life-Threatening Conditions (FANLTC) questionnaire.

Results
A total of 100 patients were recruited having 50 in each group. The pharmacist identified a total of n = 230 DRPs in the intervention group, majority of the DRPs were attributed to inappropriate drug selection according to guidelines/formulary”; “inappropriate combinations of drugs or with herbal medications or dietary supplements”; and situations where “too many different drugs or active ingredients were prescribed”. There was 46.52% reduction in the DRPs while comparing baseline and endpoint interventions suggested by pharmacist in the intervention group. The clinical pharmacist provided interventions in order to resolve the DRPs, and 37.40% interventions were accepted and fully implemented; 31.30% of the interventions were accepted and partially implemented. The clinical pharmacist identification and proposed intervention for DRPs contributed to a statistically significant improvement in QoL, from mean ±  SD scored 58.64 ±  9.10 at the baseline to 74.48 ± 10.11 at the endpoint, with a p-value of < 0.001.

Conclusion
A significant improvement in the QoL and laboratory parameters for patients with CKD following clinical pharmacist-led interventions having proposed interventions were implemented successfully from baseline to endpoint; however, a considerable number of proposed interventions were not accepted and implemented.
The impact of polypharmacy on health outcomes in the aged: A retrospective cohort study
Authors: Boateng Irene , Pascual Carlos Rodriguez , Grassby Paul , Asghar Zahid , Ibrahim Kinda 
Published: February 2025

Objectives
To estimate the prevalence of polypharmacy among community-dwelling adults in the UK and determine its association with mortality, hospitalization, adverse drug reactions and falls at one and five years. To also determine the effect of polypharmacy on the outcomes in different patient groups.

Methods
A retrospective cohort study was carried out using 1000 patients aged 75 years and above from the Clinical Practice Research Datalink. The study periods for the one- and five-years analysis were January 2010-December 2010 and January 2010-December 2014 respectively. Sociodemographic and clinical variables were retrieved using medical and product codes. Polypharmacy was defined as the use of five or more medicines. The association between polypharmacy and mortality, falls, adverse drug reactions, or hospitalization was determined using cox regression analysis while confounding for age, sex, Charlson’s comorbidity index, potentially inappropriate medicines, hospitalization prior to study, and falls prior to study. Subgroup analysis was used to determine the effect of polypharmacy on the outcomes for different patient groups.

Key findings
977 people were reviewed. 36% were male and the mean age was 83 years. The prevalence of polypharmacy was 47%. Adjusted hazard ratios with their 95% confidence intervals for association between polypharmacy and outcomes at five years were: mortality 1.60 (1.30–2.00), hospitalization 1.49 (1.30–1.70), falls 1.49 (0.90–2.40) and adverse drug reactions 0.97 (0.50–1.80). The results for the one-year analysis were mortality 2.37 (1.40–3.90), hospitalization 2.47 (1.40–4.30), and falls 0.37 (0.03–4.00).

Conclusion
Polypharmacy was found to be a risk factor for mortality and hospitalization. The risk increased with an increase in age, potentially inappropriate medicines and comorbidities.
Gradescope in Large Lecture Classrooms: A Case Study at Indiana University
Authors: Hansel Carrie A. , Ottenbreit-Leftwich Anne , Quick Joshua D. , Greene Anna Hungerfield , Ricci Maggie 
Published: February 2025

This qualitative, multi-case study explores how instructors at one higher education institution used an emerging technology, Gradescope, in their large classes to support the assessment of student learning. The study examines the practices of two instructors who taught large lecture classes with more than 100 students and used Gradescope to assist with the assessment of student learning. Results indicate that using Gradescope helped the instructors overcome specific challenges associated with large lecture courses, such as grading a large volume of assignments, , providing timely feedback, and maintaining grading consistency across large numbers of students and graders. Course DFW rates decreased and average course grades increased during the semester where the instructors used Gradescope. Instructors reported increased grading efficiency and improved student satisfaction. However, the use of Gradescope is not entirely responsible for the positive impacts. Instructors also described adapting their teaching methods and assessment strategies to integrate Gradescope effectively.
Revize vzdělávacího obsahu bezpečnostní problematiky pohledem klíčových aktérů kurikulární reformy
Authors: Kovaříková Miroslava 
Published: February 2025

Text pojednává o problematice začlenění bezpečnostní problematiky do Rámcových vzdělávacích programů v ČR v aktuálně probíhající revizi kurikula. Článek prezentuje data z kvantitativní výzkumné studie realizované v lednu 2023 metodou dotazníku. Výběr respondentů byl specifický, zařazeni byli učitelé základních a středních škol, kteří se výuce bezpečnostních témat aktivně věnují v praxi a jednou z jejich profesních aprobací je Výchova ke zdraví. Kritéria výběru splnilo 298 z celkového počtu 438 respondentů, kteří byli zařazeni do vyhodnocení. V textu je nastíněn vývoj kurikula bezpečnostních témat v historickém kontextu koncepčních změn v systému vzdělávání.
Cíle – Výzkumná studie si klade za cíl odhalit názory učitelů na probíhající kurikulární reformu v oblasti výuky bezpečnostních témat. Dalším cílem je zjistit vztah mezi hodnocením důležitosti výuky a náročnosti na přípravu učitelů na výuku a hodnocením vlastní kompetentnosti v dané oblasti.
Metody sběru dat – Pro potřeby výzkumné studie byl zvolen kvantitativní typ šetření. Použitou metodou sběru dat byl dotazník.
Metody analýzy dat – Byla provedena primární analýza jednotlivých otázek a následně i sekundární analýza výsledků. K vyhodnocení otázek byly použity statistické metody Mannův–Whitneyho U-test a Spearmanův korelační koeficient.
Výsledky a závěry – Ukázalo se, že učitelé hodnotí bezpečnostní témata jako důležitá pro připravenost žáků pro život a zařazení této problematiky do vzdělávací oblasti Člověk a zdraví, resp. Člověk, jeho zdraví a bezpečí, hodnotí jako správné rozhodnutí. Mezi 15 sledovanými tematickými okruhy existují rozdíly ve vnímání důležitosti témat. K nejméně důležitým tématům patří podle oslovených respondentů téma živelních pohrom ve světě a téma obrany státu. I tak ale zůstává jejich průměrné hodnocením důležitosti vysoké: 7,1 a 7,3 z 10 možných bodů. Je tedy zřejmé, že jsou učiteli považována za témata patřící do vzdělávání. Ukázalo se, že tato témata jsou také respondenty nejčastěji navrhována jako rozvíjející učivo. Dále bylo zjištěno, že hodnocení vlastní kompetentnosti výuky ve sledovaných tématech vzrůstá s délkou pedagogické praxe, s výjimkou tématu ochrana obyvatelstva. Téma obrany státu hodnotí respondenti jako jedno z obtížných na přípravu a uvádějí i nízké hodnocení kompetentnosti k výuce.
Simple steps to achieve harmonisation and standardisation of dried blood spot phenylalanine measurements and facilitate consistent management of patients with phenylketonuria
Authors: Carling Rachel S. , Barclay Zoe , Cantley Nathan , Ghansah Nana , Hogg Sarah L. , Horman Alistair , Moat Stuart J. , Cowen Simon , Hopley Chris , Deaves Chloe , Whyte Emily 
Published: February 2025

Abstract

Objectives
Management of phenylketonuria (PKU) relies upon life-long monitoring of phenylalanine (Phe) in dried blood spots (DBS), thus comparability of measurements is important. The lack of harmonisation and standardisation between laboratories, combined with the variable quality of patient-collected DBS specimens, are currently preventing this from being achieved. A traceable, matrix-matched Phe certified reference material, common methodology and means to ensure patient collected DBS specimens are of consistent quality would improve comparability between laboratories.

Methods
Baseline inter-laboratory (n=15) variation of DBS Phe was determined by triplicate measurement of four DBS materials, on three days. Laboratories prepared and analysed these samples using their routine method of analysis. A sub-set of laboratories (n=5) repeated the process using a common sample preparation and instrument methodology (LC-MS/MS), and three different calibration approaches. Samples prepared on dried blood spot microsampling cards (DBS-MCs) from whole blood, value assigned for Phe concentration by National Measurement Laboratories (NML), were then analysed using the harmonised methodology.

Results
Inter-laboratory co-efficient of variation (CV) differed with calibration approach; internal calibration 27.7 %; in-house aqueous calibration 4.7 %; centrally distributed aqueous calibration, 2.1 %. Inter-laboratory CV was reduced from 8.7 to 2.1 % by using common sample preparation and LC-MS/MS methodology. No significant difference was observed between consensus and assigned values for Phe in the four materials (p>0.05).

Conclusions
This study demonstrates a simple approach to harmonising and standardising DBS Phe measurements, traceable to value assigned materials. Combined with the introduction of DBS-MCs to ensure specimen quality, clinical laboratories can achieve comparability of patient results over time.
Regional Space–time Differences and Dynamic Evolution Law of Real Estate Financial Risk in China
Authors: Xia Beibei 
Published: February 2025

Abstract
This study develops a framework to evaluate real estate financial risk from three perspectives: internal risk factors, external risk factors, and interconnected risk factors, examining regional space–time differences and dynamic evolution laws across 30 provinces in China. The research finds that (1) interconnected risk factors are key contributors to real estate financial risk. (2) Significant regional differences in real estate financial risks exist across China. The western and northeastern regions are hotspots for risk, while the eastern region exhibits the most pronounced market stratification and polarization. (3) There is significant spatial autocorrelation in China’s real estate financial risks, with most provinces showing high–high (HH) and low–low (LL) clustering. HH clusters are primarily located in the western and northeastern regions, while LL clusters are more prevalent in the central and eastern regions. (4) The distribution of real estate financial risks follows a single-peak evolutionary pattern, characterized by the dynamic transition of weakening LL clusters and strengthening HH clusters. (5) The dynamic evolution of China’s real estate financial risks exhibits strong “spatial stickiness” and “positive reinforcement.” Over time, the probability of regions transitioning to higher-risk types increases, demonstrating a trend toward escalating risk levels.
Insights in non-CAH pediatric primary adrenal insufficiency: a single-center experience from India
Authors: Daga Aaditya , Karlekar Manjiri , Lila Anurag , Sarathi Vijaya , Sharma Anima , Memon Saba Samad , Barnabas Rohit , Patil Virendra , Thakker Hemangini , Shah Nalini , Bandgar Tushar 
Published: February 2025

Abstract

Objectives
Pediatric primary adrenal insufficiency (PAI) etiologies beyond congenital adrenal hyperplasia (CAH) show regional variations. Given limited data from India, this study aims to describe the etiological profile, phenotype, and genotype of pediatric PAI in an Indian cohort.

Methods
We conducted a retrospective review of patients with PAI onset before 20 years of age from 1998 to 2023 at a single center. After excluding patients with inadequate data (n=20), CAH (n=218), and bilateral adrenalectomy (n=19), we analyzed demographic, clinical, biochemical, and genetic data of the remaining patients.

Results
Among 54 patients (45 probands), the median age at presentation was 6 years (range 0.1–19). Common clinical features included hyperpigmentation (90.7 %), adrenal crisis (33.3 %), and seizures (29.6 %). Mineralocorticoid deficiency was present in two-third patients including one patient each with AAAS, MRAP, and NNT mutation. Adrenoleukodystrophy (ALD) was the most common cause (40 %), followed by ACTH resistance states (20 %), early steroidogenic defects (13.3 %), congenital adrenal hypoplasia (11.1 %), autoimmune causes (8.9 %), and tuberculosis (4.5 %). Genetics diagnosed 14/15 patients without phenotypic clues and confirmed diagnoses in 21 tested of 30 with phenotypic pointers (alacrimia in AAAS, hypoparathyroidism/candidiasis in autoimmune polyendocrine syndrome-1 and neurodeficit in ALD). Genetics differentiated CYP11A1 mutation from suspected ALD in two siblings with neurological deficits. We identified seven novel gene variants. We report the first case of NNT associated with 46,XY gonadal dysgenesis. Adrenal tuberculosis was a unique cause of pediatric PAI.

Conclusions
This study reveals diverse non-CAH pediatric PAI etiologies in India, emphasizing genetic testing’s importance for precise diagnoses and suggests region-specific diagnostic algorithm.
Sociolinguistic research projects as brands
Authors: Wagner Suzanne Evans , Sneller Betsy , Rechsteiner Jack 
Published: February 2025

Abstract
Sociolinguistic projects can benefit from brand management practices to meet their research goals. This is especially (but not exclusively) relevant for projects involving longitudinal relationships between the researcher and the community. Scholars may be skeptical of branding, because it can evoke the idea of institutions spending money on corporate image rather than on research or teaching support. Yet by curating their project’s brand as an indexical field, sociolinguists can bring more intention to their project vision. This intentionality in turn helps to save time and energy by making all decisions easier, and by improving communication to project stakeholders. The paper offers an overview of relevant public sector brand theory and gives examples from four recent sociolinguistic projects: MI Diaries, Accent Bias in Britain, Manchester Voices, and Our Dialects.
Plant endophytic bacteria reduce phthalates accumulation in soil-crop-body system: a review
Authors: Huang Ziyi , Chen Yanli , Zou Jieying , Zhou Peng , Huang Xingyu , Zhuang Ruihao , Wang Xinyu , Liu Lihui 
Published: February 2025

Abstract
Phthalate esters (PAEs) represent a class of widely utilized plasticizers, resulting in their pervasive presence in soil and agricultural crops, which poses significant risks to human health. This review examines the current state of PAE pollution, the microbial resources available for PAE degradation, and the associated degradation pathways. It highlights the advantages of endophytic bacteria over environmental microorganisms, including the prolonged survival of inoculated strains, in vivo biodegradation of PAEs, and multifunctional capabilities. Furthermore, the mechanisms by which endophytic bacteria mitigate PAE accumulation across the three defense lines (soil, crops, and the human body) are elucidated. The integrated approach of employing both plants and microbial agents for the remediation of PAEs demonstrates considerable potential for ensuring the safety of agricultural products and safeguarding human health. This work offers new insights into addressing the challenges posed by organic pollutant contamination and reducing PAE accumulation in the human body.
ОЦЕНКИ ПЕРИОДИЧНОСТИ СИНОПТИЧЕСКИХ ВАРИАЦИЙ ХАРАКТЕРИСТИК АЭРОЗОЛЯ В АРКТИЧЕСКОЙ АТМОСФЕРЕ И ВКЛАД РАЗЛИЧНЫХ ЗАГРЯЗНЕНИЙ В АНОМАЛЬНО ВЫСОКИЕ КОНЦЕНТРАЦИИ АЭРОЗОЛЯ
Authors: КРУГЛИНСКИЙ И.А. , КАБАНОВ Д.М. , САКЕРИН С.М. 
Published: February 2025

Исследуется влияние дальних переносов континентального аэрозоля на загрязнение арктической атмосферы. На основе многолетних измерений характеристик аэрозоля в атмосфере Евразийского сектора Северного Ледовитого океана (СЛО) оценивается периодичность их синоптических вариаций. В периодограммах концентраций субмикронного аэрозоля и черного углерода ( Vf и еВС) проявились статистически значимые максимумы амплитудных функций в диапазоне от 3,5 до 18 сут. Более детально рассмотрены случаи аномально высоких концентраций еВС и Vf (5% данных), связанных с дальними переносами континентальных загрязнений. Показано, что средняя продолжительность «аномалий» еВС и Vf равна 1 сут, а максимальная - 112 ч. Временные интервалы между «аномалиями» составляют в среднем 6-16 сут, а максимальные - от 28 до 69 сут. Несмотря на малую продолжительность и редкость аномальных ситуаций, они увеличивают средние концентрации аэрозоля и еВС на 28-77%. Расчеты показали, что основной (79%) вклад в загрязнение атмосферы Карского и Баренцева морей принадлежит выносам антропогенных эмиссий, а в Восточном секторе СЛО - дымам лесных пожаров. Влияние продуктов сжигания попутного газа на предприятиях газонефтедобычи больше всего (до 51%) проявилось в атмосфере над научно-исследовательским стационаром «Ледовая база „Мыс Баранова“». Полученные результаты позволяют количественно оценить вклад различных типов аэрозольных загрязнений в природную среду Арктики.
The periodicity of synoptic-scale variations in aerosol characteristics in the atmosphere of Eurasian sector of the Arctic Ocean is analyzed on the basic of long-term measurements. Statistically significant maxima of amplitude functions in the range from 3.5 to 18 days were manifested in periodograms of the concentrations of submicron aerosol and black carbon ( Vf and еВС). Cases of anomalously high еВС and Vf (5% of data), associated with long-range transports of continental pollutants, were considered in more detail. It is shown that the average duration of “anomalies” in еВС and Vf is few days, and the maximal duration attains 112 hours. The time intervals between “anomalies” are, on the average, 6-16 days, and the maximal intervals are from 28 to 69 days. Despite the short duration and rare occurrence of anomalous situations, they increase the average concentrations of aerosol and black carbon by 28-77%. Calculations showed that the major (79%) contributors to air pollution over the Kara and Barents Seas are made by the outflows of anthropogenic pollutants; and in the eastern sector of the Arctic Ocean, the contribution of smokes from wildfires is maximal. The effect of the products of associated gas combustion at gas-oil plants was manifested most strongly (up to 51%) in the atmosphere of Cape Baranov.
Sororal
Authors: Spinoza Allure 
Published: February 2025

Sororal explora la relación de tres hermanas marcada por secretos y rivalidades. En un contexto en donde se busca someter los derechos reproductivos al parecer de los hombres, Marla, Nina y Mirta confrontan sus elecciones de vida, sus cuerpos y la maternidad. La dinámica entre las hermanas revela profundas fracturas emocionales y una lucha constante por reivindicar sus propios caminos, en un entorno que busca limitar sus elecciones.
Toward resolving normality-disorder boundary issues in gaming disorder research
Authors: King Daniel L. , Billieux Joël , Behm Sanni , Delfabbro Paul H. 
Published: February 2025

AbstractA longstanding challenge in the behavioral addictions field has been determining the point at which gaming involvement becomes clinically significant problematic use. Gaming disorder (GD) and hazardous gaming as recent ICD-11 diagnoses have attracted polarized perspectives due in part to the global popularity of recreational gaming and gaming culture. The broad continuum of gaming can often be perceived differently by different parties, including gamers themselves; what might be seen as regular, harmless, and normative to some, may be considered risky and problematic by others. The ICD-11 guidelines provide some clarity by advising that gaming disorder should not be diagnosed based on persistent gaming alone; that gaming as part of a routine, developing skills, changing mood or relieving boredom, or facilitating social interaction is not sufficient for a diagnosis; and that cultural and peer group norms should be considered in diagnosis. In this paper, we examine gaming normality-disorder boundary issues in the areas of conceptualization, assessment, and interventions. Some examples of the complex personal, social, and cultural considerations that arise in gaming diagnoses are provided. We call for researchers in the addiction and health disciplines to grapple with conceptual controversy and conduct the empirical and clinical research needed to ensure that normal recreational gaming is always clearly distinguished from harm and disorder.
Motivasi dan Kepercayaan Diri Atlet Pelatda PON XX Rugby Jawa Barat
Authors: Hidayatullah Arif 
Published: February 2025

Motivasi beserta kepercayaan diri dari seorang atlet merupakan hal yang penting, karena motivasi berguna mendorong atlet tersebut agar melakukan hal yang menjadi tujuannya dan sedangkan kepercayaan diri berguna memberikan rasa yakin terhadap atlet agar melakukan hal apapun secara maksimal. Penelitian ini bertujuan untuk mengetahui bagaimana motivasi dan kepercayaan diri atlet dalam menjalani program PELATDA PON XX Rugby Jawa Barat. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan naturalistik kualitatif. Partisipan pada penelitian ini adalah pelatih beserta atlet dari PELATDA rugby yang berjumlah delapan orang. Teknik pengambilan partisipan disini menggunakan purposive sampling. Instrumen pada penelitian ini yaitu peneliti sendiri dengan menggunakan teknik pengumpulan data wawancara dan dokumentasi. Hasil penelitian ini menunjukkan bahwa faktor motivasi intrisik yang mendorong atlet dalam menjalankan PELATDA ini yaitu minat dan bakat atlet memiliki tingkatan sebesar 37,5%, pengetahuan memiliki tingkatan sebesar 25%, harga diri memiliki tingkatan sebesar 25%, dan aktualisasi diri sebesar 12,5%. Selain itu faktor motivasi ekstrinsik tersebut berupa pelatih memiliki tingkatan sebesar 100%, orang tua sebesar 100%, sarana dan prasarana sebesar 100%, lingkungan sebesar 100%, kompetisi dengan teman sebesar 25%, reward sebesar 25%, metode latihan 100%. Sedangkan dari segi kepercayaan diri atlet, meliputi faktor internal yang dapat menumbuhkan kepercayaan diri atlet berupa pengalaman sebesar 50%, kondisi fisik sebesar 37,5%, dan konsep diri sebesar 50%. Selain itu ada juga faktor eksternal yang dinyatakan para informan berupa faktor persuasi verbal memiliki tingkatan sebesar 50%, dan faktor lingkungan memiliki tingkatan sebesar 62,5% terhadap kepercayaan diri atlet tersebut.