bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doppler ultrasound combined with intravascular ultrasound-guided lower limb arterioplasty and stenting for occlusive femoropopliteal artery disease
Authors: Tan Junjie , Chen Xiaojie , Li Jihua , Jiang Yurong , Ma Ying , Chen Jianqiao , Wang Chunyan , Bai Xiao , Xu Weiguo 
Published: December 2023

Abstract
Purpose
Endovascular therapies have become common clinical treatment modalities for lower extremity atherosclerotic occlusion. Traditional digital subtraction angiographic images provide limited information, whereas Doppler and intravascular ultrasound, as adjunctive imaging techniques, provide real-time dynamic vascular information. The aim of this study was to investigate the feasibility, safety, and efficacy of Doppler ultrasound combined with intravascular ultrasound-guided percutaneous transluminal angioplasty for treating femoral popliteal chronic total occlusive lesions.
Materials and Methods
The clinical data of 13 patients (13 limbs) with chronic total occlusive lesions of the lower limb arteries who underwent Doppler ultrasound with intravascular ultrasound-guided percutaneous transluminal angioplasty at the Interventional Treatment Center were retrospectively analyzed. The primary evaluation criterion was the procedural success rate. The secondary evaluation criteria were the differences between preoperative and postoperative ankle-brachial index, blood creatinine level, and estimated glomerular filtration rate. Procedural success was defined as the placement of a guidewire through the occluded segment of the femoropopliteal artery followed by either balloon dilatation or stent placement as planned.
Results
All patients (100%) successfully underwent the procedure as planned. The ankle brachial index, which was 0.236 ± 0.072 preoperatively, significantly increased to 0.825 ± 0.079 after the procedure (t = 18.474, P = 0.000). The differences between the preoperative and postoperative glomerular filtration rate estimates and blood creatinine levels were not statistically significant, indicating that the procedures did not compromise renal function.
Conclusion
Doppler ultrasound combined with intravascular ultrasound-guided percutaneous transluminal angioplasty was a dynamic, precise, and safe regimen for treating femoral popliteal chronic total occlusive lesions.
Biosynthesis of Zinc Oxide Nanoparticles Using Averrhoa Bilimbi Fruit Extract: Deagglomeration and Antibiofilm Activity Measurements
Authors: Samadhi Tjokorde Walmiki , Wonoputri Vita , Khairunnisa Shafira , Rahayu Eka 
Published: December 2023

Abstract
Zinc oxide nanoparticle was biosynthesized using Averrhoa bilimbi fruit extract as reducing and capping agent, with a focus on the impact of in-situ deagglomeration method on physical properties and pathogenic inhibition activity against Escherichia coli biofilm. Biosynthesis variables included deagglomeration method (ultrasonication vs. PVA as deagglomerant), temperature (30, 60 °C), and zinc precursor/plant extract volumetric ratio (1:2, 2:1). Upon calcination at 375 °C, crystalline ZnO nanoparticles with high phase purity were obtained. The final product formed soft agglomerates, as indicated by hydrodynamic mean particle diameters of 1.0-3.5 mm compared against mean individual particle diameter of 22 nm. Chemical deagglomeration and lower precursor/extract ratio promoted smaller agglomerates. Interaction between deagglomeration method and biosynthesis temperature implied that physical deagglomeration was more effective at higher temperature while the opposite applied for chemical deagglomeration. Antibiofilm activity of the nanoparticles was indicated by an average E. coli population reduction of 61% at 50 ppm ZnO dose, which increased to 78% at 200 ppm dose. Lower biosynthesis temperature and precursor/extract ratio increased antibiofilm activity, likely due to higher availability of residual plant extract biomolecules in the final ZnO nanoparticle product. Deagglomeration method did not directly impact the activity. However, the combination of chemical deagglomeration and higher ZnO dose produced a synergistic effect in inhibiting the E. coli biofilm growth. Overall, ZnO nanoparticle synthesized using Averrhoa bilimbi fruit extract exhibited promising antimicrobial activity against E. coli.
Development and Validation of a Risk Prediction Model for Sleep Disorders among Senior High School Students in China
Authors: Zhang Miaomiao , Zhou Ying , Wang Xu , Deng Guoying , Zhang Zhong 
Published: December 2023

Abstract

Background
Sleep disorders are extremely harmful to the health and learning abilities of senior high school students. This issue has garnered significant societal attention. The study aims to develop and validate a risk prediction model for identifying sleep disorders among senior high school students in China, thereby enabling schools and parents to identify high-risk individuals and implement timely interventions.
Methods
This study is a cross-sectional study. Cluster sampling was employed to recruit participants from senior high school students in China for the purpose of conducting a questionnaire survey from July to August 2021. The questionnaire includes demographic information, psychological status, lifestyle habits, and sleep status. We divided the data into training and validation sets using a 7:3 ratio. The logistic regression method was used to construct a prediction model, and the model was visualized using a nomogram. To evaluate the model’s discrimination, we utilized the area under the receiver operating characteristic curve. Calibration plots and the Hosmer-Lemeshow test were also used to evaluate calibration. Furthermore, decision-curve analysis was used to assess clinical practicality.
Results
This study included 4793 senior high school students, 24.2% of whom had sleep disorders. Multivariate logistic regression analysis showed interpersonal sensitivity, anxiety, depression, high academic pressure, coffee consumption, alcohol consumption, smoking, eating before bedtime, staying up late, a poor sleep environment, and prolonged use of hand-held electronic devices were the risk factors for sleep disorders in senior high school students. We used these factors to construct a nomogram model. The AUC values for the training and validation sets were 0.862 (95% CI = 0.847-0.876) and 0.853 (95% CI = 0.830-0.876), respectively. Additionally, the Hosmer-Lemeshow test values for the training and validation sets were P = 0.682 and P = 0.1859, respectively.
Conclusion
The prediction model constructed in this research has good predictive performance. It is helpful for schools to identify high-risk groups for sleep disordersand provide references for subsequent prevention and treatment.
Association between Serum Monoterpene Levels, Hand Grip Strength, and Lean Muscle Mass in a Representative Sample of US Adults: NHANES 2013- 2014
Authors: Fang Yu-Wei , Wang ChiKang , Lin Chien-Yu 
Published: December 2023

Abstract
Background
Monoterpenes, a class of organic compounds with the molecular formula C10H16, have been the subject of considerable research due to their promising medicinal properties. Recent experiments suggest that they may have beneficial effects on skeletal muscles. However, the effects of exposure to monoterpenes on muscle strength and mass in humans remain unknown.
Methods
To address this knowledge gap, we included 1,202 adults (aged ≥ 18 years) from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) to investigate the potential relationship between serum levels of three specific monoterpenes (α-pinene, β-pinene, and limonene), hand grip strength, and lean muscle mass.
Results
Our analysis showed that except for test 2 of hand 1, all other grip strength measures showed a positive correlation with ln-limonene levels. The coefficient (ß) for combined grip strength was 2.409 (S.E. = 0.891, P = 0.015). We also observed positive associations between serum limonene levels and lean muscle mass in several areas, including arms, legs, trunk, and total body. The ß coefficient for the appendicular skeletal muscle mass index (ASMI) was 0.138 (S.E. = 0.041, P = 0.004). In addition, we found an interaction between sex and limonene, as well as between body mass index and limonene, with respect to the association with combined grip strength.
Conclusions
Our findings suggest a plausible association between exposure to limonene, hand grip strength, and lean muscle mass among adults in the United States. Further investigation is needed to fully understand the underlying mechanisms and medical significance of this association.
Association Between Trough Serum Vancomycin Concentration and Vancomycin-Associated Acute Kidney Injury and 30-Day Mortality in Critically Ill Elderly Adults
Authors: chen jialong , Lin Jing , Weng Jianzhen , Ju Yang , Li Yanming 
Published: December 2023

Abstract
Background: Vancomycin-associated acute kidney injury (VA-AKI) is the most clinically relevant side effect of vancomycin.
Method: Elderly patients with trough serum vancomycin concentration records(VTC) in the Medical Information Mart-IV (MIMIC-IV) and eICU databases were retrospectively studied.
Results: A total of 3,146 critically ill elderly adults were finally enrolled. The incidence of VA-AKI in the elderly population was 76.5%. Logistic regression analysis revealed significant relationships between VA-AKI and various factors, including VTC, comorbidities, and laboratory indicators, and SOFA, and GCS score. For each mg/L increase, the OR for VA-AKI increased by 2.5%. The association between VTC and 30-day mortality was found to be statistically significant (odds ratio (OR): 1.021, 95% CI: 1.010-1.031), P < 0.001). The Restricted cubic splines (RCS) curves revealed that VTCranged of 19.67 to 35.72mg/l for AKI and 19.17 to 42.86mg/l for 30-day mortality exhibit OR with 95% CIabove 1, indicating statistically significant associations with an increased risk of AKI and 30-day mortality, respectively. In the subgroup analysis, VTC was identified as a risk factor for VA-AKI in specific patient groups, including white individuals, female patients, those with shock, patients with SOFA >6, patients with baseline creatinine >1.2 mg/dl and patients with or without exposed to other nephrotoxic medications.
Conclusion: This study found the significant association between VTC and the incidence of VA-AKI and 30-day mortality in critically ill elderly adults. The RCS curves indicated concentration ranges for AKI (19.67-35.72 mg/L) and 30-day mortality (19.17-42.86 mg/L), signifying increased risk.
Reinforcing Face Anti-Spoofing with Multi-Scale Modality
Authors: Zhang Licheng , Luo Dingsheng , Wu Xihong 
Published: December 2023

Abstract
Face anti-spoofing (FAS) plays an important role in protecting face recognition systems. State-of-the-art works attempt to employ multi-scale contextual information contained in feature maps to raise FAS performance. These multi-scale based methods 1) fuse feature pyramids at different levels in networks, or 2) merge features extracted from multiple face crops, or 3) combine a number of hand-crafted features as multi-scale features. Previous works are awkward in leverage multi-scale benefits, leading to limited performance improvement. Here in this paper, we propose a new multi-scale based approach for FAS. Different from state-of-the-art methods, we design a multi-scale module, which can extract multi-scale feature representations at different scales, and embed it in certain positions in FAS networks. In our self-designed multi-scale module, we employ atrous convolution as well as average pooling followed by upsampling, both of which can extract multi-scale features. We conduct extensive experiments on four benchmark databases, i.e., OULU-NPU, SiW, CASIA-MFSD and Replay-Attack. Results show that our proposed multi-scale based method: 1) not only achieves state-of-the-art performance on intra database testing (especially 2.5% ACER in protocol 4 of the OULU-NPU database and 0.65% ACER in protocol 3 of the SiW database), 2) but also generalizes well on cross database testing (particularly 19.6% HTER from Replay-Attack to CASIA-MFSD databases).
FLEW: a DNS solver for compressible flows in generalized curvilinear coordinates
Authors: Soldati Giulio , Ceci Alessandro , Pirozzoli Sergio 
Published: December 2023

Abstract
We present FLEW, an in-house high-fidelity solver for Direct Numerical Simulation (DNS) of turbulent compressible flows over arbitrary shaped geometries. FLEW solves the Navier-Stokes equations written in a generalized curvilinear coordinate system, in which the surface coordinates are non-orthogonal, whereas the third axis is normal to the surface. Spatial discretization relies on high-order finite-difference schemes. The convective terms are discretized using an hybrid approach, combining the near-zero numerical dissipation provided by central approximations with the robustness of Weighted Essentially Non-Oscillatory (WENO) schemes, required to capture shock waves. Central schemes are stabilized using a skew-symmetric-like splitting of convective derivatives, endowing the solver with the energy-preserving property in the inviscid limit. The maximum order of accuracy is eighth for central schemes (also used for viscous terms discretization) and seventh for WENO. The code is oriented to modern High-Performance Computing (HPC) platforms thanks to Message Passing Interface (MPI) parallelization and the ability to run on Graphics Processing Unit (GPU) architectures. Reliability, accuracy and robustness of the code are assessed in the low-subsonic, transonic and supersonic regimes. We present the results of several benchmarks, namely the inviscid Taylor-Green vortex, turbulent curved channel flow, transonic laminar flow over a NACA 0012 airfoil and turbulent supersonic ramp flow. The results for all configurations proved to be in excellent agreement with previous studies.
The first national study on managing female fertility preservation in Tunisian prepubertal girls and women with cancer: Where are we in 2023?
Authors: Boughzala Ines , Sallem Amira , Kooli Rim , Boussabbeh Manel , Garrouch Dorra , Mehdi Meriem 
Published: December 2023

Abstract

Background
The incidence of cancers is increasing worldwide. Female patients of prepubertal age as well as those of reproductive age are eligible for fertility preservation (FP). The lack of literature data focusing on the state of the art of managing fertility preservation among Tunisian women with cancer encouraged us to conduct the current study.
Methods
This descriptive, observational and multicentric national study was conducted online. A survey containing 24 questions was sent to 529 Tunisian oncologists and hematologists covering all the Tunisian territory. Two reminders were sent by e-mail 2 weeks later each.
Results
A total of 74 responses were received and analyzed. The answering rate was 13.9%. Infertility risks were discussed with patients of reproductive age by 66.2% of all physicians surveyed, and 62.2% referred patients to a fertility center before beginning treatments. The most mentioned FP technique was oocyte cryoconservation (60.8%). Collaborating with a fertility center was the most recommended way to enhance the effectiveness of FP according to the interviewed physicians. A percentage of 2.7% of practitioners considered themselves knowledgeable in FP techniques.
Conclusion
This study is to the best of our knowledge the first national survey to explore oncofertility management in Tunisia. This showed that the FP field is still in the processing range. We recommend in light of these results, the establishment of national guidelines to provide cancer patients with the appropriate information with regard to FP. A more effective collaboration between cancer and fertility centers is also needed for better management of fertility preservation for female patients in Tunisia.
Study on geopolymer recycled foam concrete based on waste wood flour and its engineering performance
Authors: Xu Chenyang , Wang Peihan , Guo Huijuan , Liu Haibao , Zhang ZhiZhu , Shao Changhai , Li Qiuyi , Guo Yuanxin 
Published: December 2023

Abstract
In order to improve the application of forestry by-products, This study explores the possibility of using waste wood flour to prepare geopolymer recycled foam concrete (GRFC) in architectural applications to reduce the use of mineral aggregates and improve the thermal insulation performance of the concrete. Compared with mineral aggregate, waste wood flour has advantages in density, toughness and water absorption. In addition, the addition of waste wood powder and foam at the same time will change the structural morphology of ordinary foam concrete. Therefore, this experiment explores the water retention performance, thermal insulation performance, mechanical properties (compressive strength, flexural strength, bond strength), toughness, shrinkage rate and compactness under different foam and waste wood powder (WFA) content, which makes an exploration for replacing ordinary mortar and ordinary foam concrete.The results showed that the addition of WFA strengthens the stability between pores in the honeycomb structure, and inhibits the loss of foam in the newly mixed slurry due to different internal and external humidity. It is also an effective way to improve the water retention performance, thermal insulation performance and embrittlement of ordinary mortar and foamed concrete. However, foam seems to have a negative effect on interfacial transition zone (ITZ) of wood flour and cement pastes.
Role of child marriage on women’s nutritional status in adulthood
Authors: Datta Biplab , Fazlul Ishtiaque 
Published: December 2023

Abstract
Background: Child marriage, defined as marriage before the age of 18 years, could have detrimental impacts on women’s physical and psychological development affecting health outcomes in adulthood. This observational study aimed to examine whether women’s nutritional status, measured by body mass index (BMI) categories, was associated with being married in childhood.
Methods: Using nationally representative repeated cross-sectional data on 822,642 married women, aged 20 to 49 years, from the 2015-16 and 2019-21 waves of India National Family Health Survey, we assessed the risk of underweight, overweight, and obesity conditions, relative to having BMI at the normal threshold, between women who were married as children and as adults.
Results: Estimates of the baseline multinomial logistic regression model, without controlling for household wealth, showed that women married in childhood were 1.09 times more likely to be underweight and 7.5% and 8.3% less likely to be overweight or obese, respectively. However, when household wealth index quintiles were adjusted, women married as children were found 8.2% less likely to be underweight, and 1.12 and 1.23 times more likely to be overweight or obese, respectively. These results were robust across different birth cohorts and geographic region sub-groups and indicated a classic case of the Simpson’s paradox.
Conclusion: We found that compared to women who were married as adults, women married in childhood had a higher risk of overweight and obesity. Our estimates of this relationship can play an important role in educating public health stakeholders and stimulating further research aimed at informing targeted policy interventions.
Study on the Vibration Behavior of the Head of an Upright Seated Human under Vertical Whole-Body Vibration
Authors: Dong Ruichun , Lu Zhuangqi , Liu Zhong , Jiang Hui , Zhu Shuai , Zhang Kaifeng 
Published: December 2023

Abstract
To investigate the response behavior of the human head in upright sitting, a seated human finite element model with detailed skeletal and muscular soft tissues was created based on human biomechanics. The vertical first-order resonant frequency of each segment model was calculated by modal analysis, and the seat-to-head transmissibility (STHT) of the seated human finite element model was calculated by the random response method. The model had been verified through simulation and experimental studies. It was found that the upright seated human under vertical whole-body vibration showed an apparent resonance phenomenon around 5.7 Hz. The maximum value of the direct-axis response of the head in the sagittal plane was located in the posterior occipital region, where the STHT was 10% larger than that at the crown and 23% larger than that at the forehead. The direct-axis responses of the head in various positions within the coronal plane were almost identical. The maximum value of the cross-axis response was located at the crown of the head, and the response peaks in the sagittal and coronal planes were symmetrical about this point. Moreover, the maximum difference of direct-axis response at different positions reached 119%. Additionally, we found that the seated human body had not only Significant vertical and fore-aft displacements but also head rotation, leading to complex coupling vibration of the head. This study provides a reference and theoretical basis for the seated human head response measurement, model creation, and vibration comfort evaluation.
Level-set-based topology optimization of threedimensional structures considering the manufacturing process with realistic milling tools
Authors: Colling Christopher , Schumacher Axel , Mecking Klaus 
Published: December 2023

Abstract

In this work, we develop an approach for the level set based topology optimization of millable 3D structures. We focus on the 3-axis machining with realistic formed milling tools. The basis of the method lies in the identification of surface areas that cannot be reached by a given milling tool during optimization. For this purpose, we present an interpolation method that identifies these areas by an interpolation of the level set function along the outer contours of realistic milling tools, considering available machining directions. To minimize inaccessible regions, we define a potential field whose values decrease linearly into the outer normal direction of the structure. The inaccessible regions are pushed outward by minimizing their respective potential and therefore become accessible. Manufacturability is integrated into the optimization problem as an explicit constraint.
Nano delivery of antitubercular drugs to the brain: pharmacokinetic and therapeutic implications in mice model of tuberculous meningitis
Authors: Majeed Shahnawaz , parry ZahoorAhmad , Sharma Sadhna 
Published: December 2023

Abstract
Tuberculous meningitis is the most severe form of extrapulmonary tuberculosis. Though it represents approximately 1% of all cases of tuberculosis, it causes mortality or severe disabilities in almost fifty percent of the patients affected. Current treatment of the disease involves the use of Isoniazid, Rifampicin, and Pyrazinamide which is associated with a number of drawbacks like the limited ability of antitubercular drugs to cross the blood-brain barrier, hepato and nephrotoxicity issues, lengthy treatment schedule, and patient non-compliance. To overcome the limitations, Polybutylcyanoacrylate (PBCA) nanoparticles encapsulating anti-tubercular drugs were synthesized by anionic polymerization and double coated with PEG+P-80 for oral delivery of drugs to the brain. Nanoparticles were in nanosize range and sterically stable. Pharmacokinetic analysis showed sustained release of drugs in the plasma for about 96h and their retention in the brain for up to 12 days after single dose oral administration of nanoencapsulated antitubercular drugs. A murine model of tuberculous meningitis was developed by intracranial administration of Mycobacterium tuberculosis H37Rv in mice and chemotherapeutic efficacy of nano-encapsulated drugs was evaluated in the infected mice model. Drug-loaded PBCA nanoparticles were found to be more effective than free drugs for the treatment of tuberculous meningitis as 4 or 8 doses of the nano-encapsulated formulation were equi-efficacious to 32 or 64 doses of free drugs administered daily.