bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy storage devices: batteries and supercapacitors
Authors: Abraham Taniya Rose , Sunil Kevin , Shah Muhammed , Ashok Neelesh , Thomas Sabu 
Published: January 2024

Abstract
Energy storage devices play a crucial role in our modern society, enabling the efficient utilization of renewable energy sources, powering portable electronics, and facilitating the transition to electric transportation. The chapter begins by exploring the need of energy storage in the modern world, the fundamental principles and working mechanisms of batteries, including the different types such as lithium-ion, nickel-metal hydride and lead-acid battery. The design, manufacturing and performance characteristics of each battery type are discussed, along with their advantages and limitations. Additionally, the chapter discusses the latest advancements in battery technology, including the development of solid-state batteries, high-energy-density batteries, and next-generation battery materials. Moreover, the chapter examines supercapacitors, an emerging energy storage technology with unique advantages such as high-power density, fast charging, and greater cycle life. The underlying principles and operating principles of supercapacitors are explained, with a focus on different types such as electrochemical double-layer capacitors and pseudocapacitors. Also, the chapter explores the various electrode materials, electrolytes, and device architectures employed in supercapacitors, highlighting recent advancements and future prospects.
The Mechanism of Action and Experimental Verification of Narenmandula
in the Treatment of Postmenopausal Osteoporosis
Authors: Xiao Jirimutu , Yu Ziceng , Han Qiuge , Guo Yang , Ye Jiapeng , Lian Hua , Wang Lining , Ma Yong , Liu Mengmin 
Published: January 2024

Background::
Narenmandula is a classic ancient remedy in Inner Mongolia, historically
used for gastrointestinal diseases. In recent decades, Inner Mongolia Medical University found
that it has a significant effect in promoting fracture healing and increasing bone density, and has
been used to treat postmenopausal osteoporosis (PMOP), but its mechanism is unclear.

Objective::
Identify the mechanism of action of Narenmandula for PMOP treatment.

Methods::
Network pharmacology, molecular docking and ovarian departing rat models were used
to verify the relevant mechanism of Narenmandula in the treatment of PMOP.

Results::
We confirmed that NRMDL prescription can improve OVX-induced bone loss, improve
trabecular density, and relieve osteoporosis. Upon screening of network pharmacology, we obtained
238 overlapping genes of Narenmandula and PMOP, and analyzed AKT, IL1B, and IL6 as
key genes by network topology. Among the 1143 target genes that interact with PMOP, 107
NRMDL active compounds correspond to 345 target genes and 238 overlapping genes. Network
topology analysis showed the top 8 active ingredients, such as quercetin and kaempferol, and the
top 20 key genes, such as AKT, IL1B, IL6, INS, JUN, STAT3, TNF, TP53, etc. Enrichment analysis
revealed involvement of PI3K-Akt, HIF-1, FoxO, MAPK, and TNF signaling pathways. In
addition, we found the most important active compounds bind tightly to core proteins, which were
verified by molecular docking analysis. The AKT-related pathway had good binding energy, and
the pathway was verified by cell and animal experiments.

Conclusion::
The potential mechanism and efficacy of Narenmandula against PMOP may be related
to the PI3K-AKT pathway.
Evaluation of the Mechanism of Yishan Formula in Treating Breast Cancer Based on Network Pharmacology and Experimental Verification
Authors: Lin Xiaoyue , Chi Wencheng , Geng Xue , Jiang Qinghui , Ma Baozhu , Dai Bowen , Sui Yutong , Jiang Jiakang 
Published: January 2024

Background:
Yishan formula (YSF) has a significant effect on the treatment of breast
cancer, which can improve the quality of life and prolong the survival of patients with breast
cancer; however, its mechanism of action is unknown.

Objective:
In this study, network pharmacology and molecular docking methods have been used
to explore the potential pharmacological effects of the YSF, and the predicted targets have been
validated by in vitro experiments.

Methods:
Active components and targets of the YSF were obtained from the TCMSP and Swiss
target prediction website. Four databases, namely GeneCards, OMIM, TTD, and DisGeNET,
were used to search for disease targets. The Cytoscape v3.9.0 software was utilized to draw the
network of drug-component-target and selected core targets. DAVID database was used to analyze
the biological functions and pathways of key targets. Finally, molecular docking and in
vitro experiments have been used to verify the hub genes.

Results:
Through data collection from the database, 157 active components and 618 genes implicated
in breast cancer were obtained and treated using the YSF. After screening, the main active
components (kaempferol, quercetin, isorhamnetin, dinatin, luteolin, and tamarixetin) and
key genes (AKT1, TP53, TNF, IL6, EGFR, SRC, VEGFA, STAT3, MAPK3, and JUN) were obtained.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment
analysis indicated that the YSF could affect the progression of breast cancer by regulating
biological processes, such as signal transduction, cell proliferation and apoptosis, protein phosphorylation,
as well as PI3K-Akt, Rap1, MAPK, FOXO, HIF-1, and other related signaling
pathways. Molecular docking suggested that IL6 with isorhamnetin, MAPK3 with kaempferol,
and EGFR with luteolin have strong binding energy. The experiment further verified that YSF
can control the development of breast cancer by inhibiting the expression of the hub genes.

Conclusion:
This study showed that resistance to breast cancer may be achieved by the synergy
of multiple active components, target genes, and signal pathways, which can provide new avenues
for breast cancer-targeted therapy.
A Network Pharmacology-based Study on the Anti-aging Properties of Traditional Chinese Medicine Sisheng Bulao Elixir
Authors: Xing Cencan , Zeng Zehua , Shan Yubang , Guo Wenhuan , Shah Roshan , Wang Luna , Wang Yan , Du Hongwu 
Published: January 2024

Background::Traditional Chinese Medicine (TCM) has a rich history of use in preventing senescence for millennia in China. Nonetheless, a systematic method to study the antiaging properties and the underlying molecular mechanism of TCM remains absent.Objective::The objective of this study is to decipher the anti-aging targets and mechanisms of Sisheng Bulao Elixir (SBE) using a systematic approach based on a novel aging database and network pharmacology.Methods::Bioactive compounds and target proteins in SBE were identified via the Traditional Chinese Medicine System Pharmacology (TCMSP) database. Aging-related proteins were uncovered through alignment with the Ageing Alta database. A compound-target (CT) protein network analysis highlighted key flavonoids targeting aging. Core aging-related proteins were extracted through protein-protein interaction (PPI) network analysis. Molecular docking validated binding activities between core compounds and aging-related proteins. The antioxidant activity of SBE was confirmed using an in vitro senescent cells model.Results::A total of 39 active compounds were extracted from a pool of 639 compounds in SBE. Through a matching process with the Aging Alta, 88 target proteins associated with the aging process were identified. Impressively, 80 out of these 88 proteins were found to be targeted by flavonoids. Subsequently, an analysis using CT methodology highlighted 11 top bioactive flavonoids. Notably, core aging-related proteins, including AKT1, MAPK3, TP53, VEGFA, IL6, and HSP90AA1, emerged through the PPI network analysis. Moreover, three flavonoids, namely quercetin, kaempferol, and luteolin, exhibited interactions with over 100 aging-related proteins. Molecular docking studies were conducted on these flavonoids with their shared three target proteins, namely AKT1, HSP90AA1, and IL6, to assess their binding activities. Finally, the antioxidant properties of SBE were validated using an in vitro model of senescent cells.Conclusion::This study offers novel insights into SBE's anti-aging attributes, providing evidence of its molecular mechanisms. It enhances our understanding of traditional remedies in anti-aging research.
Insulin Therapy on Bone Macroscopic, Microarchitecture, and Mechanical
Properties of Tibia in Diabetic Rats
Authors: Oliveira Limirio Pedro Henrique Justino , De Oliveira Neto Nilson Ferreira , Venâncio Jessyca Figueira , Linhares Camila Rodrigues Borges , Soares Priscilla Barbosa Ferreira , Dechichi Paula 
Published: January 2024

Background:
This study evaluated tibia's macroscopic structure, mechanical properties,
and bone microarchitecture in rats with type 1 diabetes mellitus (T1DM).

Methods:
Eighteen animals were divided into three groups (n=6): non-diabetic (ND), diabetic (D),
and diabetic+insulin (DI). T1DM was induced by streptozotocin; insulin was administered daily
(4IU). The animals were euthanized 35 days after induction. The tibiae were removed and analyzed
using macroscopic, micro-computed tomography (micro-CT) and three-point bending. The macroscopic
analysis measured proximal-distal length (PD), antero-posterior thickness (AP) of proximal
(AP-P) and distal (AP-D) epiphysis, and lateral-medial thickness (LM) of proximal (LM-P)
and distal (LM-D) epiphysis. Micro-CT analysis closed porosity, tissue mineral density, and cortical
thickness. The three-point bending test measured maximum strength, energy, and stiffness.

Results:
The macroscopic analysis showed that D presented smaller measures of length and thickness
(AP and AP-P) than ND and DI. More extensive measurements were observed of LM and
AP-D thickness in DI than in D. In micro-CT, DI showed larger cortical thickness than D. Mechanical
analysis showed lower strength in D than in other groups.

Conclusions:
T1DM reduces bone growth and mechanical strength. Insulin therapy in diabetic rats
improved bone growth and fracture resistance, making diabetic bone similar to normoglycemic
animals.
Comprehensive Factors for Predicting the Complications of Diabetes
Mellitus: A Systematic Review
Authors: Erandathi Madurapperumage Anuradha , Wang William Yu Chung , Mayo Michael , Lee Ching-Chi 
Published: January 2024

Background:
This article focuses on extracting a standard feature set for predicting the
complications of diabetes mellitus by systematically reviewing the literature. It is conducted and
reported by following the guidelines of PRISMA, a well-known systematic review and meta-analysis
method. The research articles included in this study are extracted using the search engine
"Web of Science" over eight years. The most common complications of diabetes, diabetic neuropathy,
retinopathy, nephropathy, and cardiovascular diseases are considered in the study.

Method:
The features used to predict the complications are identified and categorised by scrutinising
the standards of electronic health records.

Result:
Overall, 102 research articles have been reviewed, resulting in 59 frequent features being
identified. Nineteen attributes are recognised as a standard in all four considered complications,
which are age, gender, ethnicity, weight, height, BMI, smoking history, HbA1c, SBP, eGFR, DBP,
HDL, LDL, total cholesterol, triglyceride, use of insulin, duration of diabetes, family history of
CVD, and diabetes. The existence of a well-accepted and updated feature set for health analytics
models to predict the complications of diabetes mellitus is a vital and contemporary requirement.
A widely accepted feature set is beneficial for benchmarking the risk factors of complications of
diabetes.

Conclusion:
This study is a thorough literature review to provide a clear state of the art for academicians,
clinicians, and other stakeholders regarding the risk factors and their importance.
Rapidly Evolving SARS-CoV-2: A Brief Review Regarding the Variants
and their Effects on Vaccine Efficacies
Authors: Nawaz Shahid , Janiad Sara , Fatima Aiman , Saleem Maira , Fatima Urooj , Ali Asad 
Published: January 2024

Abstract:
Since the commencement of Corona Virus Disease 2019 (COVID-19) pandemic, which
has resulted in millions of mortalities globally, the efforts to minimize the damages have equally
been up to the task. One of those efforts includes the mass vaccine development initiative targeting
the deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). So far, vaccines have
tremendously decreased the rate of transmission and infection in most parts of the world. However,
the repeated resurgence of different types of mutated versions of the virus, also known as variants,
has somehow created uncertainties about the efficacies of different types of vaccines. This review
discusses some of the interesting SARS-CoV-2 features, including general structure, genomics, and
mechanisms of variants development and their consequent immune escape. This review also focuses
very briefly on antigenic drift, shift, and vaccine-developing platforms.
Exposure to Endocrine-disrupting Chemicals and Environmental Toxins
Attributing to Polycystic Ovarian Syndrome
Authors: Mandal Subrata , Begum Rukaiah Fatma , Vellapandian Chitra , Mohan Sumithra 
Published: January 2024

Abstract:
Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by ex-cess androgen and infertility due to anovulatory failure. A significant fraction of the world's popu-lation is affected by the infertility condition known as PCOS. Due to the disease's complicated na-ture and overlapping symptoms, diagnosis of the condition is frequently challenging. Exogenous compounds or combinations known as endocrine-disrupting chemicals (EDCs) can imitate the ef-fects of steroid hormones and obstruct their metabolism. EDCs and this condition have recently been the subject of intensive research to better understand the possible contribution of these sub-stances to the pathophysiology of PCOS. It was shown that EDC exposure can be connected to PCOS in either a direct or indirect way since PCOS is linked to higher levels of oxidative stress and inflammation, which lead to obesity, insulin resistance, and infertility. This review's objective is to investigate how exposure to environmental contaminants affects the etiology of polycystic ovarian syndrome.
Application of eHealth Tools in Anticoagulation Management After Cardiac Valve Replacement: Scoping Review Coupled With Bibliometric Analysis
Authors: Wu Ying , Wang Xiaohui , Zhou Mengyao , Huang Zhuoer , Liu Lijuan , Cong Li 
Published: January 2024

Background
Anticoagulation management can effectively prevent complications in patients undergoing cardiac valve replacement (CVR). The emergence of eHealth tools provides new prospects for the management of long-term anticoagulants. However, there is no comprehensive summary of the application of eHealth tools in anticoagulation management after CVR.

Objective
Our objective is to clarify the current state, trends, benefits, and challenges of using eHealth tools in the anticoagulation management of patients after CVR and provide future directions and recommendations for development in this field.

Methods
This scoping review follows the 5-step framework developed by Arksey and O’Malley. We searched 5 databases such as PubMed, MEDLINE, Web of Science, CINAHL, and Embase using keywords such as “eHealth,” “anticoagulation,” and “valve replacement.” We included papers on the practical application of eHealth tools and excluded papers describing the underlying mechanisms for developing eHealth tools. The search time ranged from the database inception to March 1, 2023. The study findings were reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). Additionally, VOSviewer (version 1.6.18) was used to construct visualization maps of countries, institutions, authors, and keywords to investigate the internal relations of included literature and to explore research hotspots and frontiers.

Results
This study included 25 studies that fulfilled the criteria. There were 27,050 participants in total, with the sample size of the included studies ranging from 49 to 13,219. The eHealth tools mainly include computer-based support systems, electronic health records, telemedicine platforms, and mobile apps. Compared to traditional anticoagulation management, eHealth tools can improve time in therapeutic range and life satisfaction. However, there is no significant impact observed in terms of economic benefits and anticoagulation-related complications. Bibliometric analysis suggests the potential for increased collaboration and opportunities among countries and academic institutions. Italy had the widest cooperative relationships. Machine learning and artificial intelligence are the popular research directions in anticoagulation management.

Conclusions
eHealth tools exhibit promise for clinical applications in anticoagulation management after CVR, with the potential to enhance postoperative rehabilitation. Further high-quality research is needed to explore the economic benefits of eHealth tools in long-term anticoagulant therapy and the potential to reduce the occurrence of adverse events.
Use of microalgae Scenedesmus quadricauda and Chlorella vulgaris living-cells suspensions for plant biostimulation
Authors:   Laboratory of Industrial Microbiology and Food Biotechnology, Institute of Biology, University of Latvia, Kolesovs Sergejs , Neiberts Kristaps , Semjonovs Pavels 
Published: January 2024

Up to date research on microalgae as plant biostimulants remains fragmented and use of living microalgal cell suspensions is understudied. This research focuses on use of Scenedesmus quadricauda and Chlorella vulgaris living-cells suspensions as growth stimulants for garden cress (Lepidium sativum). Different concentrations of microalgal biomass suspensions were tested. It was found that plant treatment with S. quadricauda biomass 0.8 g/L (dry weight) suspension resulted in a significant improvement in L. sativum seeds germination and growth rate.
Caracterização de uma transição de fase contínua em um sistema caótico
Authors: Leonel Edson D. , Kuwana Célia M. 
Published: January 2024

Discutimos uma invariância de escala para a difusão caótica em uma transição de fase de integrabilidade para não integrabilidade em uma classe de sistemas dinâmicos descritos por um mapeamento bidimensional, não linear e preserva a área no espaço de configurações. As variáveis que descrevem o sistema são a ação I e o ângulo θ. Este tem a propriedade de divergir no limite em que a ação é suficientemente pequena. A transição de fase é controlada por um parâmetro ϵ. Uma invariância de escala observada para a ação quadrática média ao longo do mar caótico prova que a transição observada da integrabilidade para a não integrabilidade é equivalente a uma transição de fase de segunda ordem, que é também conhecida como transição de fase contínua. Uma evidência clara disso refere-se ao fato de que o parâmetro de ordem se aproxima de zero ao mesmo tempo que a susceptibilidade - resposta do parâmetro de ordem à variação do parâmetro de controle - diverge no mesmo limite.
Evaluación de la toxicidad genética de la yerba mate (Ilex paraguariensis) en Allium cepa
Authors: D Lerda , P Gargantini 
Published: January 2024

INTRODUCCIÓN: La Yerba Mate, es una infusión hecha de las hojas del árbol Ilex paraguariensis, planta de la familia Aquifoliaceae. Es una bebida que se consume principalmente en los países de América del Sur como Argentina, Uruguay, Brasil, Paraguay y está logrando una mayor penetración en Estados Unidos como en otros países del mundo.
OBJETIVO: El presente estudio evalúa la genotoxicidad de la yerba mate (Ilex paraguariensis), previamente probado para la presencia de hongos toxigénicos en cultivos específicos.
MATERIAL Y METODOS: Se utilizó el sistema Allium cepa para el estudio de genotoxicidad, las células meristemáticas fueron tratadas con una infusión filtrada de mate, con agua destilada como control negativo y Dimetilsulfóxido (DMS) al 0,2 % como control positivo.
RESULTADOS: El crecimiento radicular fue reducido dependiendo de la concentración, y al estudiar la proliferación celular se observó que la frecuencia de células mitóticas se reducía progresivamente a medida que aumentaba la concentración de yerba mate. Por otra parte, se observó un aumento en la frecuencia de células aberrantes con la concentración de yerba mate más alta (1400 µg/ml).
CONCLUSIONES: Los hallazgos de este estudio muestran que la yerba mate induce efectos clastogénicos en las raíces meristemáticas de Allium cepa.
La voz de las mujeres: el tránsito de víctimas a la legitimidad como constructoras de paces
Authors: Osorno Navarro Mara , Posada Zapata Isabel 
Published: January 2024

El objetivo fue analizar las formas de afrontamiento de las violencias sexuales en mujeres víctimas sobrevivientes y su participación en los procesos de construcción de paz. Fue una investigación cualitativa a través de la Teoría Fundamentada, con el Interaccionismo Simbólico para originar la teoría, desde los significados que surgen en la interacción entre las personas y su entorno. Se recolectó la información con entrevistas a profundidad. La teoría construida resalta la experiencia de las violencias sexuales, la cual simboliza desazón, exilio, destrucción de sus metas y proyectos, la dificultad para perdonar por la magnitud del daño e incumplimiento de las leyes. Aunado a esto, las condiciones del territorio y su historia influyeron en los significados que las personas participantes asignaron a su experiencia inolvidable por las huellas del dolor; una de las formas de afrontamiento fue poder alzar su voz como un instrumento fundamental para el tránsito de víctimas a la legitimidad como constructoras de paces. Se concluye que, en la unión y en la mutualidad, encontraron la manera de legitimar sus voces y hacerlas oír por sus comunidades. El significado de la paz en las mujeres está representado en el estar en armonía, disfrutar de su cotidianidad, sentirse libres, sentirse importantes y únicas cuando hablan de la historia de dolor.