bluuebunny/crossref_metadata_2025_split huggingface dataset:
USP49 inhibits ferroptosis via activation of the SHCBP1-β-catenin-GPX4 pathway, promoting the malignant progression of adenocarcinoma of the esophagogastric junction
Authors: Ding Yun , Liu Zhen , Dai Xiaofeng , Ruan Ruiwen , Zhong Hongguang , Wu Zhipeng , Yao Yangyang , Chen Jun , Deng Jun , Xiong Jianping 
Published: November 2023

Abstract
Background: Adenocarcinoma of the esophagogastric junction (AEG) has received widespread attention because of its increasing incidence. However, the molecular mechanism underlying tumor progression remains unclear.
Methods: Malondialdehyde assay, lipid peroxidation and Transmission electron microscopy were used to evaluate ferroptosis. Cell proliferation was determined using CCK-8, EdU assay and cell colony formation assays. A xenograft animal model in vivo was established by subcutaneous injection of stable cell lines into the flank of nude mice. Western blotting and Immunohistochemistry were performed to evaluate protein expression in cells and patient tissues, respectively. Additionally, the interaction of Ubiquitin-specific peptidase 49 (USP49) and Shc SH2-domain binding protein 1 (SHCBP1) was detected by immunofluorescence(IF), coimmunoprecipitation (Co-IP), cycloheximide and ubiquitination assays. was used to determine USP49 and GPX4 expression in.
Results: Here, we report that the downregulation of USP49 promotes ferroptosis in OE33 and OE19 cells, thereby inhibiting cell proliferation in vitro and in vivo, whereas the overexpression of USP49 had the opposite effect. In addition, USP49 downregulation promoted radiotherapy sensitivity in OE33 and OE19 cells. Moreover, the downregulation of USP49 reduced the mRNA and protein levels of glutathione peroxidase 4 (GPX4), and the overexpression of GPX4 rescued the malignant biological behavior induced by USP49 knockdown. Mechanistically, USP49 deubiquitinates and stabilizes Shc SH2-domain binding protein 1 (SHCBP1), subsequently facilitating the entry of β-catenin into the nucleus to enhance GPX4 transcriptional expression. Finally, high USP49 expression was correlated with shorter overall survival in patients with AEG.
Conclusions:In summary, our findings identify USP49 as a novel regulator of ferroptosis in AEG cells, indicating that USP49 may be a potential therapeutic target in AEG.
Theoretical investigation of threshold pressure gradient in hydrate-bearing clayey-silty sediments under combined stress and local thermal stimulation conditions
Authors: Qu Jiangtao , Lei Gang , Liu Tianle , Sun Jiaxin , Zheng Shaojun , Qu Bo 
Published: November 2023

Abstract

Due to the characteristics of smaller grain size and higher clay mineral content, a threshold pressure gradient (TPG) exists in multi-phase flow within hydrate-bearing clayey-silty sediments (HBCSS), which significantly affects the hydrate production. However, the dissociation of hydrates can result in cementation loss, changes in effective stress, and variation in local temperature. As a result, the TPG in HBCSS differs from that of conventional geotechnical materials. Until now, the understanding of TPG in HBCSS with complex pore structures and hydrate distribution is unclear. In this study, we have developed a theoretical TPG model for HBCSS that takes various factors into account, such as effective stress, temperature increase, pore structures, hydrate saturation, and growth patterns. The proposed TPG model for HBCSS has been thoroughly validated using available experimental data. Additionally, we conducted a parameter sensitivity analysis based on this derived model, revealing a positive correlation between TPG and both effective stress and temperature increase. Furthermore, while TPG generally increases with higher hydrate saturation when other parameters are held constant, the relationship between TPG and hydrate saturation is non-monotonic. This observation suggests that TPG is influenced not only by hydrate saturation but also by other factors, including hydrate growth patterns and pore structures. The findings of this study establish a theoretical foundation for characterizing the nonlinear flow behavior during hydrate exploitation.
Eating Disorders, Attention Deficit Hyperactivity Disorder, and Social Functioning: A Conditional Process Analysis
Authors: González-Martell M.S. Angely K. , Vélez-Pastrana María C. 
Published: November 2023

Abstract
Background: This study examined the relationship between eating disorder (ED) and ADHD symptoms and their impact on social functioning. It aimed to clarify the mechanisms whereby the symptoms of ED cause impairment through their impact on general social functioning.
Method: A community sample of 160 Latino adults completed an anonymous online survey including self-report measures of symptoms of ED and ADHD, social functioning, and social functioning related to eating behavior. We tested a conditional process model that posits that social functioning related to eating behavior mediates the effect of ED on general social functioning, while ADHD symptoms moderate the effect of ED on general social functioning.
Results: Results support the hypothesized model. We show that the effect of ED on social functioning is fully mediated by social functioning related to eating behavior. However, we found no evidence of a significant conditional effect of ED symptoms on general social functioning as being moderated by ADHD symptoms at the levels of ADHD symptoms that we tested. Overall, increased ED and ADHD symptoms, as well as poorer social functioning related to eating behaviors, were associated with reduced general social functioning.
Conclusions: Both eating disorder and ADHD symptoms are associated with diminished general social functioning. This underscores the importance of screening for and addressing ADHD symptoms in ED populations, and vice versa, in clinical settings. The findings highlight the important role of social functioning related to eating behavior as the mechanism whereby ED symptoms cause impairment by diminishing general social functioning. We discuss clinical and research implications.
Experimental study on the damage performance and forced response of concrete lining in fault-crossing tunnel
Authors: Hu Hui , Lan Youdi , Liu Yun , Qiu Wenge 
Published: November 2023

Abstract
Understanding the adverse effects of tunnel crossing active faults on tunnel structures is crucial for ensuring their safe operation and construction. This paper presents the results of a series of model tests conducted at a scale of 1:40 using a fault sliding test box. Three sets of fault comparison tests were carried out, namely: (1) the tunnel does not cross the fault, (2) the spring stiffness is reduced, and (3) the model is not reinforced. The objective was to study the failure characteristics of tunnels crossing active faults. The findings reveal that when the upper wall moves downwards, cracks appear on the surrounding rock surface of the upper wall, specifically above the tunnel lining crossing the fault. The lining is significantly damaged within the range of -30cm~+30cm. All points of axial force exhibit an increasing compression trend. The section of axial force and bending moment near the fault fracture surface is notably larger than that far from the fault fracture surface. The safety factor of the entire structure decreases sharply after dislocation, making the tunnel more susceptible to cracking at various locations such as the vault, arch waist, left and right arch feet, and inverted arch. It has been proven that the shear compression of the fracture surface during fault dislocation is the main cause of longitudinal through cracks in the lining. The use of springs with higher stiffness effectively ensures the reciprocating dislocation of the upper and lower walls, with long duration and large displacement, providing a better simulation of the dislocation of active faults.
Non-linear association of atherogenic index of plasma with hyperuricemia in US adults: a cross- sectional study
Authors: Yang Xin , Chen Pei-nan , Wu Bin , Liao Jie-ying , Shi Bingchun , Li Yutao , Yang Xu 
Published: November 2023

Abstract

Background
Hyperuricemia is related to various cardiometabolic diseases in US adults, having an increasingly substantial impact on healthcare resources and costs. Nonetheless, there are limited studies examining the association between atherogenic index of plasma(AIP) and hyperuricemia in middle-aged and elderly individuals.
Methods
We carried out a cross-sectional research study using data obtained from the National Health and Nutrition Examination Survey (NHANES). All 12,261 participants were classified according to the AIP quartiles. Participants aged ＜18 years old, without BMI, waist, blood pressure, SCr, TG, HDL-C, LDL-C data, alcohol use, and smoking behavior information were excluded. The atherogenic index of plasma (AIP) is calculated as the log triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). We explored the association between AIP and the risk of hyperuricemia using multivariate ordinal logistic regression. Hyperuricemia is widely defined as serum uric acid levels that are at or above 360 mmol/l in women and 420 mmol/l in men.
Results
Among 12261 participants included (mean age, 48.0 years), 6080 were male. The prevalence of hyperuricemia was 20.73% in the cross-sectional study. The multivariate-adjusted hazard ratios [HRs; 95% confidence interval (CI)] for hyperuricemia gradually and significantly increased with the AIP quartiles [1.26 (1.06, 1.49) in Q2, 1.63 (1.39, 1.93) in Q3, and 2.06 (1.76, 2.43) in Q4], following an adjustment for potential confounders. And we observed a non-linear dose–response and a consistent relationship between them after the interaction test stratified by age, sex, BMI, hypertension, diabetes, smoking, and alcohol.
Conclusions
On a continuous scale, per 1 unit increase in AIP was associated with multivariable-adjusted odds ratios (95% CI) of 2.06 (1.76, 2.43) for having a higher risk of hyperuricemia. These findings suggested the potential of AIP as an independent risk indicator in preventing hyperuricemia.
Evaluation of Cardiac Autonomic Dysfunctions in Children with Type 1 Diabetes Mellitus
Authors: GÖZÜKÜÇÜK Davut , İLERİ Berkut Alkım , BAŞKAN Serra KARACA , ÖZTARHAN Ece , GÜLLER Dilek , ÖNAL Hasan , ÖZTARHAN Kazım 
Published: November 2023

Abstract
Background:Type 1 diabetes mellitus (T1DM) is one of the most common endocrine and metabolic diseases in children. Cardiovascular autonomic neuropathy (CAN) is an important and overlooked complication of diabetes, which almost doubles the mortality. Therefore early recognition and treatment will prevent the development of cardiovascular events. Aim of our study is to determine the necessary parameters to recognize cardiovascular dysfunctions that may develop due to CAN in the early period.
Methods:In our study, 30 healthy children and 30 T1DM patients with poor glycemic control were evaluated. Echocardiographic data, heart rate variability (HRV) with 24-hour Holter electrocardiography, exercise capacities, and tilt table test for baroreceptor susceptibility were evaluated.
Results: In our study, 30 patients with poor glycemic control were evaluated, their mean diabetes duration was 8±3.66(1-16) years. CAN that may develop in early childhood were evaluated in the patient group. It is observed that there was a decrease in HRV, this situation is accompanied by ventricular dysfunction and postural hypotension.
Conclusion:CAN is one of the most common complications of T1DM and is associated with patient's age and poor glycemic control. Decreased baroreceptor susceptibility with autonomic dysfunction is associated with decreased ventricular diastolic functions, respiratory functions, and exercise capacity. In our study, we showed that cardiac autonomic dysfunction may develop in early childhood in T1DM patients with poor glycemic control. It may be valuable to evaluate HRV and tilt table tests in the early detection of CAN in pediatric groups.
Head Nodding and Hand Coordination Across Dyads in Different Conversational Contexts
Authors: Falk Patrick , Cañigueral Roser , Ward Jamie A , Hamilton Antonia F de C 
Published: November 2023

Abstract

This paper aims to explore what different patterns of head nodding and hand movement coordination mean in conversation by recording and analysing interpersonal coordination as it naturally occurs in social interactions. Understanding the timing and at which frequencies such movement behaviours occur can help us answer how and why we use these signals. Here we use high-resolution motion capture to examine three different types of two-person conversation involving different types of information-sharing, in order to explore the potential meaning and coordination of head nodding and hand motion signals. We also test if the tendency to engage in fast or slow nodding behaviour is a fixed personality trait that differs between individuals. Our results show coordinated slow nodding only in a picture-description task, which implies that this behaviour is not a universal signal of affiliation but is context driven. We also find robust fast nodding behaviour in the two contexts where novel information is exchanged. For hand movement, we find hints of low frequency coordination during one-way information sharing, but found no consistent signalling during information recall. Finally, we show that nodding is consistently driven by context but is not a useful measure of individual differences in social skills. We interpret these results in terms of theories of nonverbal communication and consider how these methods will help advance automated analyses of human conversation behaviours.
Measurement, Subsystem Coupling Coordination, and Spatial Convergence of the modernization of Chinese-style Governance Capability
Authors: Tian Shizhong , Jin Shaopeng 
Published: November 2023

Abstract

Promoting the modernization of the national governance system and governance capability serves as a crucial conduit to expedite the process of Chinese-style modernization. Based on the study of the modernization of Chinese-style governance capability (MCGC), some findings are as follows: (1) The index of MCGC demonstrates a steady upward trend with noticeable regional disparities, ranking in descending order as eastern region > central region > northeastern region > western region. The region with the highest internal disparities in MCGC is the eastern, while the northeastern region has the lowest internal disparities. The greatest interregional disparity in MCGC is observed between the eastern and western regions. (2) The indices of the five major subsystems improve annually, yet the trajectories of them are not entirely consistent. (3) The five subsystems coupling coordination degree for MCGC displays a temporal characteristic of gradual improvement and a spatial feature of gradual decrease from the eastern coastal areas to the northwestern inland areas. (4) MCGC exhibits a significant positive spatial correlation, manifesting a spatial distribution pattern of “high-high” and “low-low” aggregation. What’s more, the MCGC follows a “smooth and gradual” process, without a “multilevel leapfrogging” trajectory. And the improvement of MCGC demonstrates spatial convergence.
ZNF692 promotes the migration and response to therapy of immune checkpoint blockade regents of clear cell renal cell carcinoma cells by targeting essential genes of metabolism process pathway
Authors: Liu Yuming , Zeng Dehua , Gao Yunzhen 
Published: November 2023

Abstract
Clear cell renal cell carcinoma (ccRCC), with high mortality and poor prognosis, is the most common type of renal malignancy. It is necessary to identify new biomarkers that can serve as indicators for the detection of ccRCC at its early stages. In this study, we analyzed the role of classical zinc finger protein 692 (ZNF692) in ccRCC using datasets from The Cancer Genome Atlas (TCGA) and Single Cell Portal and immunohistochemical (IHC) staining of a tissue-microarray, and analyzed the function of ZNF692 in ccRCC cells. The analyses indicated that ZNF692 was upregulated in ccRCC samples compared with normal or paracancerous control samples (p < 0.001) and that the expression of this gene was linked to poor overall survival (HR = 2.1, p < 0.0001). The knockdown of ZNF692 inhibited the proliferation and migration of ccRCC cells by target GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2), and transmembrane 9 superfamily member 2 (TM9SF2)). Furthermore, the expression of ZNF692 mRNA was significantly upregulated in patients with mutations in the BAP1 (p = 0.025), PBRM1 (p = 0.00066), and SETD2 (p = 0.011) genes. T, B, proximal, and collecting tubule cells are the dominant cell types in normal kidney tissue where ZNF692 is expressed. In addition, immune checkpoint blockade (ICB) therapy dramatically changed the expression patterns of ZNF692. Collectively, these data indicate that ZNF692 may serve as prognosis, and as a potential indicator of the response to ICB therapy, a possibility needs to be verified by a case‒control study.
A Comprehensive Dataset of 10 Exotic Vegetable Plants Across Three Growth Stages
Authors: amin sayed mohammed 
Published: November 2023

Abstract
A Ten categories of Exotic vegetables plants dataset comprises 4,187 high-definition images representing three growth stages viz seedling, vegetative, and harvest. To support research in hydroponics, precision agriculture, and plant health monitoring, the dataset is systematically organized into folders for each growth stage. Within these primary folders, sub-folders named after the plant varieties house the corresponding images. This organizing ensures easy access and clear identification of each plant's variety and growth stage. Addressing a notable gap in hydroponic agriculture datasets, this collection provides a robust resource for the development and validation of deep learning models, especially in plant identification, growth stage detection, and health assessment.
Coevolutionary analysis of the Pfs47-P47Rec complex: a bioinformatics approach
Authors: Ortiz-Morazán Andrés S. , Moncada Marcela María , Escobar Denis , Cabrera-Moreno Leonardo A. , Fontecha Gustavo 
Published: November 2023

Abstract
Background: The ability to predict and comprehend molecular interactions offers significant insights into the biological functions of proteins. The interaction between Pfs47 and P47Rec has attracted increased attention due to their roles in parasite evasion of the mosquito immune system and the concept of geographical coevolution between distinct species. The aims of this study were: (1) to apply a bioinformatics approach to investigate the interaction between Pfs47 and P47Rec proteins, and (2) to identify the potential binding sites, protein orientations, and receptor specificity sites concerning the geographical origins of the vectors and the parasite.
Methods: The p47 gene was subjected to sequencing and subsequent analysis in two distinct Anophelesspecies collected in Honduras. In addition, public sequences of the pfs47and p47rec genes were downloaded, which were subsequently filtered to predict functional and structural annotations of the Pfs47-P47Rec complex. Phylogenetic analyses of both proteins were carried out.
Results: The findings revealed a pattern of dissemination of anophelines and parasites originating from Africa to other geographical regions. Additionally, the examination of motifs reveals a significant degree of conservation in pfs47, suggesting that Pfs47 might have undergone recent evolutionary development and adaptation. The theory of selectivity of Plasmodium falciparumstrains towards their vectors in diverse geographical regions was supported by structural models and docking analyses. A detailed description of the putative interaction between the Pfs47-P47Rec complex is shown.
Conclusions: The findings of this study unveiled coevolutionary trends between P47Rec and Pfs47, which are associated with the process of speciation and the geographical distribution of Anopheles spp and P. falciparum.
Phase-controlled coherent photons for the quantum correlations in a delayed-choice quantum eraser scheme
Authors: Ham Byoung 
Published: November 2023

Abstract
The delayed-choice quantum eraser has been intensively studied for the wave-particle duality of a single photon in an interferometric system over the last decades. Coincidence measurements between quantum erasers have also been applied for the nonlocal quantum feature, satisfying the Bell inequality violation. However, those quantum features have not been clearly understood yet, resulting in the quantum mystery. Recently a coherence approach has been tried for the quantum eraser to unveil the quantum mystery. Here, a phase quantization of higher-order intensity products between coherently controlled quantum erasers is presented using a quarter wave plate-induced phase shift between orthogonal polarization bases of a single photon. Theoretical solutions of both photonic-de-Broglie-wave-like quantum features and nonlocal quantum correlations are presented for further discussions of quantum mechanics.
Parental Acceptance of Behavior Management Techniques for Pediatric Dental Visits in Qassim, Saudi Arabia: A Cross-sectional Study
Authors: Aldhelai Thiyezen Abdullah , Shaman Almodhaibri Nimran , Alsughier Zeyad , Alharbi Saleh Abdullah 
Published: November 2023

Background:
Behaviour management techniques have been commonly used to promote a child’s positive behaviour during oral health treatment. Parents play an important role in their child’s dental care and its delivery.

Objective:
This study aimed to determine the most accepted behaviour management techniques used in paediatric dental clinics and assess the parents’ acceptance level for each technique using a visual analogue scale.

Methods:
This cross-sectional study based in Qassim, Saudi Arabia, used videotaped scenes of seven behaviour management techniques recorded in Arabic. After watching the videos, parents filled out a questionnaire on acceptance of each technique and rated their acceptance of it by using a visual analogue scale.

Results:
The study consisted of 130 parents, of which 86 (66.2%) were males and 44 (33.8%) were females. 96.9% of parents approved positive reinforcement, which was followed by tell-show-do (TSD) with 93.1% acceptance. General anesthesia (47.7%) was the least accepted behavioral management technique.

Conclusion:
It is crucial for parents to systematically understand the procedures to be used in a pediatric dental setting. Dentist-parent communication is necessary to address any concerns, thereby creating a safe environment to deliver quality oral care.