bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis
Authors: Liu Manting , Ye Jiexiang , Wu Runtian , Luo Dongqiang , Huang Tao , Dai Dandan , Wang Kexin , Du Yanping , Ou Junwen 
Published: January 2025

IntroductionSteroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition with no specific treatment. Inhibiting osteocyte apoptosis may be a promising therapeutic approach. Shengxue Busui Decoction (SBD) has shown protective effects against SONFH, but its mechanisms are not fully understood. This study aims to investigate the effects of SBD on SONFH in rats, identifying its key active components and regulatory mechanisms using network pharmacology, bioinformatics, machine learning, and experimental validation.MethodsKey active components and disease targets of SBD were identified through network pharmacology and bioinformatics. GO/KEGG enrichment and ssGSEA analyses were performed to identify critical pathways. Cytoscape and machine learning (SVM) were used for target prediction and molecular docking validation. A dexamethasone (Dex)-induced SONFH rat model was established, and SBD was administered for 60 days. Histological changes were assessed via HE staining, osteoclast activity through TRAP staining, apoptosis levels with TUNEL assays, and vascular function through hematological tests. ELISA was used to measure ALP and OCN levels. In vitro, Dex-induced osteoblast apoptosis in MC3T3-E1 cells was examined to assess SBD’s effect on osteoblast proliferation, apoptosis, and signaling. Western blotting analyzed Caspase-9, Caspase-3, Bax, Bcl-2, and pathway-related proteins. ALP and Alizarin Red staining evaluated osteoblast differentiation and mineralization.ResultsNetwork pharmacology identified curcumin, berberine, and diosgenin as key active components of SBD, with the PI3K/Akt and VEGFR pathways as critical targets, and RAF1, FOXO3, and BRAF as hub genes. In vivo, SBD intervention significantly reduced bone structural damage and apoptosis, decreasing the rate of empty bone lacunae. SBD also increased osteogenic markers ALP and OCN in SONFH rats. In vitro, SBD inhibited osteoblast apoptosis, promoted PI3K/Akt and VEGF pathway expression, and enhanced osteoblast differentiation and mineralization.ConclusionThis study integrates network pharmacology with experimental validation, showing that SBD protects against SONFH by inhibiting osteoblast apoptosis via PI3K/Akt and VEGFR pathways. SBD promotes osteoblast differentiation and mineralization, improving bone structure and vascular function. Curcumin, berberine, and diosgenin are likely key contributors to these effects, highlighting SBD as a potential therapeutic strategy for SONFH.
Data mining and safety analysis of voriconazole in patients with a hematological malignant tumor based on the FAERS database: differences between children and adults
Authors: Li Hao , Jiang Manxue , Pan Xiaona , Kong Lingti 
Published: January 2025

ObjectiveVoriconazole is a broad-spectrum antifungal agent. It is used widely for the prevention and treatment of invasive fungal infections in patients with a hematological malignancy, but studies on its safety in this population are scarce. We assessed the adverse drug events (ADEs) of voriconazole in this population based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to improve understanding of the safety of voriconazole.Research design and methodsADE reports for patients with a hematological malignant tumor using voriconazole between the first quarter of 2004 to the first quarter of 2024 were retrieved. Then, they were classified using the preferred terminology (PT) and system organ category (SOC) in the Medical Dictionary for Regulatory Activities. Data mining was done using reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS).ResultsA total of 605 ADEs were included: 116 (19.17%) in children and 489 (80.83%) in adults. The types of SOC involved in children and adults were 22 and 24, respectively. The only positive SOC signal that satisfied all four algorithms simultaneously in children was “psychiatric disorders”, whereas in adults they were “endocrine disorders” and “hepatobiliary disorders”. At the PT level, the types involved in children and adults were 28 and 74, respectively. The highest ROR signal intensities were found for “hallucinations, mixed” in children and “toxic optic neuropathy” in adults. The median time of onset of the ADE in children and adults was 11 and 8.5 days, respectively.ConclusionWe used four algorithms (ROR, PRR, BCPNN, MGPS) to mine the signals of voriconazole in patients with a hematological malignant tumor, and compared the differences between children and adults. This study is important for targeting the monitoring, and could help to improve the safety of voriconazole.
Photosynthetic characteristics of Paris polyphylla var. chinensis in response to different light intensities and soil water contents
Authors: Zhang Yaling , Xu Rong , Wang Zhaozhao , Zhang Juan , Tang Xinghao , Chen Yu , Yan Xiao-Li , Qu Lu-Ping 
Published: January 2025

IntroductionParis polyphylla var. chinensis (Franch.) Hara (P. polyphylla) is a perennial medicinal plant with a reputation for therapeutic properties. It is imperative to study the photochemical processes of P. polyphylla in order to determine the optimal levels of shading and moisture management for its cultivation in artificial environments.MethodsIn this study, six shading levels (no shading, 30%, 50%, 70%, 80% and 90% shading) and three soil water contents (20%, 40% and 60% of the soil water saturation capacity) were established to determine the appropriate shade intensity and soil moisture content for the growth of P. polyphylla.ResultsThe results showed that only the low shade groups (no shade and 30% shade) showed irreversible damage to the daily photosynthetic dynamics of the plant over the course of a day. It is important to note that excessive light can damage not only the quantum yield for electron transport (φDo) and PSII light quantum yield (Fv/Fm), but also various physiological mechanisms that can lead to overall plant damage and a decline in organic matter. A comparison of Fv/Fm during the midday period showed that the optimum shade intensity is between 50% and 70%. Low shading can significantly increase light use efficiency (LUE), but also reduces net photosynthetic rate (Pn) and transpiration (Tr), indicating the negative effect on P. polyphylla growth. Considering the balance between growth rate and damage incidence, 50% shade should be the optimal treatment for P. polyphylla, followed by 30% and 70% shade. It was also observed that treatment with low soil water content (20%) significantly reduced Pn and LUE, while increasing stomatal conductance (gs) and water use efficiency (WUE). This is associated with a decrease in the light response curve, indicating that low soil moisture inhibits the growth of P. polyphylla and increases the likelihood of irreversible light damage, so the optimum soil moisture content for P. polyphylla should be above 20%.DiscussionConsidering the economic benefits and the growth and health of P. polyphylla in artificial cultivation, it is recommended that shade be controlled at around 50% while maintaining soil moisture between 40% and 60% of water content.
Water phase distribution and its dependence on internal structure in soaking maize kernels: a study using low-field nuclear magnetic resonance and X-ray micro-computed tomography
Authors: Wang Baiyan , Gu Shenghao , Wang Juan , Wang Guangtao , Guo Xinyu , Zhao Chunjiang 
Published: January 2025

IntroductionThe formation of yield and quality in maize involves the accumulation of substances such as starch, proteins, and fats, which interact with water within the kernel. Although temporal dynamics of grain moisture and its functional and environmental determinants have been broadly demonstrated, we still do not have a comprehensive understanding of the distribution of water phase within a kernel.MethodsWe investigated the relationship between tissue structural traits, including embryo volume (EMBV), endosperm volume (ENDV), vitreous endosperm volume (VEV), floury endosperm volume (FEV), and water content in different phases, such as bound water, semi-bound water, and free water, in maize kernels under different cultivars, nitrogen application rates, and soaking durations by combining low-field nuclear magnetic resonance (LF-NMR) and X-ray microcomputed tomography (μ-CT) for kernels.ResultsThe results demonstrate that bound water is the major phase (57-82%) in maize kernels, and this proportion decreases with prolonged soaking duration. The bound water content and semi-bound water content positively correlate to ENDV, VEV, and EMBV, whereas free water content correlates to ENDV, EMBV, and VEV in descending order of correlation coefficient. This indicates that water might penetrate the embryo through the pedicel and vitreous endosperm through the pericarp during soaking.DiscussionFinally, we suggested that the proportion of semi-bound water could be a robust indicator to predict moisture content in maize kernels. The study provides a preliminary understanding of the structural basis of water distribution in maize kernels, thereby opening up the potential for designing efficient production systems and breeding cultivars well-suited for mechanical harvesting.
Screens and scars: SEM analysis of the relationship between childhood trauma, emotion regulation, and social media addiction
Authors: Elkin Nurten , Mohammed Ashraf Ashifa Kariveliparambil , Kılınçel Oğuzhan , KılınçeL Şenay , Ranganathan Maharshi , Sakarya Aslıhan Kübra , Soydan Ayşe Mücella 
Published: January 2025

BackgroundAddiction is an increasingly significant global public health concern, affecting individuals across diverse age groups and demographics. With the rapid rise of digital technology, social media addiction has emerged as a growing behavioral issue, impacting mental health, interpersonal relationships, and daily functioning.MethodsThis study employed an online cross-sectional self-report questionnaire, with university students aged 16–35 years as the target population. Data were collected using Google Forms questionnaires, accessible via the university registration system, and sent to the participating students’ smart phones. The data collection instruments included the Social Media Addiction Scale (SMAS), the Childhood Trauma Scale (CTS), and the Difficulty in Emotion Regulation Scale (DERS).ResultsData from 318 university students were analyzed. The analysis of sociodemographic data revealed a mean participant age of 21.2 years, with 87.3% being female. An analysis of the relationship between social media addiction and childhood trauma revealed that participants with childhood trauma had higher social media addiction. The linear regression model, including childhood traumas and emotion regulation difficulties for social media addiction scores, was statistically significant. A positive correlation was observed between social media addiction and difficulty in emotion regulation.ConclusionThese findings suggest that individuals who struggle with emotion regulation tend to use social media more frequently. Furthermore, the negative effects of childhood trauma on emotion regulation capabilities during adulthood contribute to the development of social media addiction.
Anxiety and depression prevalence and associated factors in patients with knee osteoarthritis
Authors: Feng Qizhen , Weng Mingjie , Yang Xi , Zhang Min 
Published: January 2025

ObjectiveWith the evolving spectrum of diseases, psychological conditions such as anxiety and depression have emerged as significant global public health concerns. Notably, these psychological disorders are prevalent among patients suffering from knee osteoarthritis (KOA). Consequently, this study included 360 hospitalized patients diagnosed with KOA to examine their levels of anxiety and depression and to analyze the factors influencing these psychological states.MethodsA cohort of KOA patients from the Second Hospital of Shanxi Medical University was assessed using a general condition questionnaire, European five-dimensional health status scale (EQ5D), Western Ontario and McMaster University Osteoarthritis (WOMAC), Social Support Rating Scale (SSRS), and Hospital Anxiety and Depression Scale (HADS). Logistic regression analysis was employed to identify the factors affecting anxiety and depression.ResultsAmong 360 patients with KOA, 28.06% experienced anxiety, and 30.27% experienced depression. Multivariate logistic regression analysis showed that lower BMI, QOL, and utilization of social support scores are risk factors for anxiety and depression in KOA patients (P&lt;0.05). Additionally, in patients with KOA, younger age, lower subjective support, and higher scores in function and daily activities emerged as significant risk factors for depression (P&lt;0.05).ConclusionAnxiety and depression in patients with KOA warrant significant attention due to their impact on overall well-being. The factors influencing these mental health conditions are multidimensional. In clinical practice, it is essential to integrate these various influencing factors to develop targeted mental health care services. By doing so, healthcare providers can enhance the overall mental health and QOL for individuals suffering from KOA.
Factors associated with the revolving door phenomenon in patients with schizophrenia: results from an acute psychiatric hospital in Romania
Authors: Dionisie Vlad , Puiu Maria Gabriela , Manea Mihnea Costin , Moisa Emanuel , Dumitru Ana Maria , Ibadula Leila , Mares Aliss Madalina , Varlam Corina Ioana , Manea Mirela 
Published: January 2025

BackgroundThe revolving door phenomenon refers to patients with frequent hospital admissions and emerged after deinstitutionalization reforms have been implemented. Schizophrenia is a severe and debilitating mental disorder and has frequently been identified as one of the most prevalent disorders among revolving door patients. Therefore, this research aimed to identify socio-demographic and clinical factors associated with the revolving door phenomenon in patients with schizophrenia.MethodsWe conducted an observational and retrospective cohort study and collected data from the medical records of individuals admitted to the largest psychiatric hospital in Romania during a 2-year period. Patients with three or more admissions during a 12-month period were identified as revolving door.ResultsOf the total of 635 patients included in this study, 108 met the criteria for revolving door. Patients had a mean age of 44.55±12.83 years and most of them were single (81.7%) and receiving a disability pension (68.7%) and had an illness duration of more than 5 years (81.9%). Male gender (p=0.000), younger age (p&lt;0.05), presence of psychiatric comorbidity (p&lt;0.05), substance use disorder (p=0.000) and alcohol use disorder (p&lt;0.01) were associated with the revolving door patients. A binary linear logistic regression revealed that male gender (OR=1.92, 95%CI:1.21-3.08), shorter hospitalization (OR=0.982, 95%CI:0.964-1.000), substance use disorder (OR=2.47, 95%CI:1.16-5.26), verbal (OR=1.44, 95%CI:1.05-1.98) and physical (OR=1.331, 95%CI:1.017-1.744) aggression were predictive factors for frequent use of inpatient services.ConclusionsThe results may facilitate development of future reform policies aimed at reducing the revolving door phenomenon, including implementing transitional care interventions between hospital and community services.
Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms
Authors: Yang Qianke , Lin Shichong , Zhang Zhuyun , Du Shuhao , Zhou Dan 
Published: January 2025

BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. Cognitive function and social activities were significantly mediated by depression. Cognitively stimulating and physically stimulating activities had the greatest positive effects on mental health.ConclusionOur findings highlight the complex interplay between social engagement, depression, and cognitive health in aging. They support developing targeted interventions promoting physical and cognitive social activities to maintain cognitive function and reduce depression risk in older adults, potentially alleviating the burden of cognitive impairment in aging populations.
Association between balance ability and cardiovascular disease onsets among middle-aged and older adults: an observational cohort study from the China Health and Retirement Longitudinal Study
Authors: Lin Yinghe , Zhong Shanshan , Sun Zhihua 
Published: January 2025

BackgroundPrevious studies showed the association between poor balance ability and a high risk of cardiovascular disease (CVD) mortality. However, there is little evidence regarding balance function and the onset of CVD. We aimed to examine the relationship between the balance ability and incident CVD risk.MethodsThis study retrospectively included participants (≥45 years) without CVD at baseline from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and those who were followed up in 2018. CHARLS used the semi-tandem stand test to assess balance ability. CVD was defined as the presence of physician-diagnosed heart disease and/or stroke. Cox proportional hazards models (considering competing risks) and stratification analysis were used to determine the association between balance ability and incident CVD risk.ResultsThe median age of the 10,154 participants was 57.0 (51.0, 64.0) years old, with 51.0% female. Compared to those with good balance ability, individuals with moderate balance ability had a higher risk of incident CVD [HR (95% CI): 1.15 (1.03–1.28)], and the risk was more pronounced in female (20.0%), rural residence (21.0%), never smoking (22.0%), never drinking (23.0%), hypertension (16.0%), without dyslipidemia (17.0%), and without kidney disease (13.0%) participants. After multiple imputations of metabolic biomarkers data, the results of sensitivity analyses were generally consistent.ConclusionLower balance ability was associated with an increased risk of incident CVD among middle-aged and older Chinese adults. The simple, economical, effective, and safe physical measurements of balance function deserve further investigation in public health.
Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications
Authors: Romaniyanto Romaniyanto , Ilyas Muhana Fawwazy , Lado Aldebaran , Sadewa Daffa , Dzikri Dykall Naf'an , Budiono Enrico Ananda 
Published: January 2025

IntroductionSpinal tuberculosis (TB), or Pott's disease, remains a significant global health issue, particularly in regions with high TB prevalence. Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required in cases of spinal instability or neurological complications. This study aims to conduct a comprehensive bibliometric analysis of worldwide publications related to the surgical management of spinal TB and to compare contributions from orthopaedic surgery and neurosurgery in this field.MethodsA bibliometric analysis was performed using data from the Scopus database, covering publications from 1896 to 2024. The search strategy focused on terms related to spinal TB and surgical interventions. The analysis included 1,857 publications, which were examined for trends, key contributors, and the evolution of surgical techniques. Metrics such as the number of publications, leading authors, affiliations, countries, and funding sponsors were compared between orthopaedic surgery and neurosurgery.ResultsThis study identified a steady increase in the number of publications over time. Key topics evolved from basic surgical methods, including early spinal procedures, to integrating pharmacological approaches alongside surgical techniques, such as antitubercular drugs, advancing into imaging research and procedure research involving refined surgical methods like spinal fusion. The recent phase reflects a shift towards technology-driven approaches, including minimally invasive techniques, artificial intelligence, and machine learning. China emerged as the leading country with the most contributions based on author, affiliations, funding sponsors, and countries. Last, orthopaedic surgery had more publications (274) than neurosurgery (96).DiscussionIn conclusion, spinal TB surgery has evolved significantly, with a notable shift towards advanced, technology-driven approaches. Orthopaedic surgery leads in research output compared to neurosurgery. This bibliometric analysis provides valuable insights into the global research landscape, guiding future studies in the management of spinal TB.
Addition of anal encirclement to perineal proctosigmoidectomy: a retrospective review
Authors: Amery Aiya , Marritt Kayla , Baig Zarrukh , Roy Haven , Gill Dilip , Ginther Nathan 
Published: January 2025

BackgroundThe optimal approach for the surgical management of rectal prolapse is individualized based on anatomical, functional, and surgical factors. In patients with significant comorbidities, perineal approaches are often preferred even though they are associated with higher recurrence rates compared to an abdominal approach. Although anal encirclement was one of the first procedures described for this condition, it is seldom employed given its high recurrence rates. There is currently a lack of data addressing a combination surgery, wherein both a perineal proctosigmoidectomy and anal encirclement are performed simultaneously.AimsTo evaluate the efficacy of combining perineal proctosigmoidectomy with anal encirclement using Nylon sutures compared to perineal proctosigmoidectomy alone.MethodsThis was a single institution, non-randomized, retrospective study conducted at the Royal University Hospital, Saskatoon, Saskatchewan, Canada (July 2017 to October 2022). Patients over the age of 18 with full-thickness rectal prolapse who underwent either perineal proctosigmoidectomy alone or perineal proctosigmoidectomy with anal encirclement were included. There were 23 patients in the perineal proctosigmoidectomy group and 21 patients in the perineal proctosigmoidectomy with anal encirclement group. The primary outcome was prolapse recurrence. Secondary outcomes included operative time, length of hospital stay, and post-operative complications.ResultsPatients who received perineal proctosigmoidectomy with anal encirclement had significantly lower rates of recurrent prolapse (9.5%) compared to perineal proctosigmoidectomy alone (34.8%) (p = 0.02). Patients who underwent the combined procedure had a shorter length of stay by 2.3 days (p = 0.03). There was no difference in post-operative complications or operating time.ConclusionsRoutine anal encirclement in perineal proctosigmoidectomy reduces recurrence rates and length of stay without increasing operating time or complications.