bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiment of a thermal plume on an open cylinder
Authors: Zhang Wei , Nie Bingchuan , Xu Feng 
Published: October 2023

In this study, we performed a set of experiments of the thermal plume on an open cylinder heated from below and a simple scaling analysis. The flow structure of the plume was visualized using the shadowgraph technique, and the temperature at specific points was measured using a thermistor. Transient plumes in a developing stage, an equilibrating stage and a fully developed stage were described. The new scaling laws of the stem radius and the velocity of the rising plume were presented, which are different from those on a two-dimensional heated plate due to the cylindrical effect and agree with experimental results. In the fully developed stage, there is a transition route of the plume from a steady to chaotic state with an increase in the Rayleigh number, which involves a series of bifurcations. A reverse bifurcation from a periodic (Ra = 1.17 × 106) back to a steady (Ra = 1.30 × 106) state has been observed in the experiment, which is referred to as the period bubbling bifurcation. Thus, the present experimental results validate the previous numerical results presented by Zhang et al. (Phys. Fluids, vol. 33 (6), 2021, 064110). The bifurcation diagram, spectral analysis and attractor are used to characterize the transitional plume. In addition, the heat and mass transfer have also been quantified.
An individual based model of female brown crab movements in the western English channel: modelling migration behaviour
Authors: Hart Paul J B , Pearson Emma , Hunter Ewan 
Published: October 2023

AbstractAn individual based model (IBM) of the female brown crabCancer paguruspopulation exploited off South Devon, UK is described. Size dependent movement rules are ascribed to individuals based on previous observations of predominantly westward migration down the English Channel. Two additional versions of the movement rules explored whether the empirically derived rule was necessary to model the temporal and spatial distribution of crabs. Local crab movement was dependent on substrate type and water depth. Females prefer a soft substrate in which they can bury when temperatures are low or they have eggs to incubate. Crabs have size dependent depth preferences with larger crabs preferring greater depths. Two recruitment functions are used which relate the number of incoming crabs to the sea surface temperature five years earlier. Model outputs were tested against 10 years of logbook data from three crab fishers and against data from a year-long sampling programme on eight of the vessels exploiting the area. The model reproduces the long-term pattern which is mostly temperature driven. Spatial variation in catch is captured effectively by the model with more crabs being caught in the east of the area than the west and more caught offshore than inshore. The significance of the results is discussed in relation to the crab life cycle, management of the fishery and the potential effects of increasing temperatures.
Hydrobiogeochemical Controls on the Delivery of Dissolved Organic Matter to Boreal Headwater Streams
Authors: Roebuck J. Alan , Prestegaard Karen , Gaviria Christian , Myers‐Pigg Allison , Ziegler Susan E. 
Published: October 2023

AbstractUnderstanding controls on the delivery of dissolved organic matter (DOM) from terrestrial to aquatic systems is key for constraining carbon balances and fluxes in boreal headwater catchments. The largest export of DOM generally occurs during intense periods of water delivery to the landscape (e.g., rain events); however, the timing and magnitude of DOM is complicated by geomorphological, hydrometeorological, and biogeochemical variability. To better assess mechanisms controlling the delivery of DOM to boreal streams, DOM was investigated in two morphologically distinct catchments of an experimental forest watershed in western Newfoundland, one dominated by low relief wetlands and the other by steep hillslopes. The DOM was compared during two fall storms of similar magnitude but contrasting moisture conditions during the autumn transition. Variable concentrations and optical character highlighted antecedent conditions are important for the delivery of DOM to boreal streams. Concentration‐discharge relationships with stream hydrograph separation analysis suggest preferential flowpaths through shallow mineral horizons as a key pathway for delivery of DOM in the hillslope dominated catchment compared to rapid input from near‐stream wetlands in the low relief catchment. Loss of DOM via preferential pathways suggests an additional mechanism for surface soil carbon loss not directly informed by lateral flow and soil hydrology, which has important implications for our conceptualization and modeling of carbon fluxes in boreal systems. These results suggest watershed scale responses of DOM in boreal headwater catchments are complex, and better linkages between catchment scale hydrology and landscape hydrobiogeochemistry are required to constrain terrestrial to aquatic carbon fluxes in boreal landscapes.
Constraining the Lithospheric Discontinuity Structure Beneath Hawaiʻi Using Teleseismic Receiver Functions
Authors: Herr Brandon , Delph Jonathan 
Published: October 2023

AbstractThe Hawaiian Islands represent the youngest portion of the long‐lived Hawaiian‐Emperor Seamount chain sourced from hotspot volcanism on the northwesterly moving Pacific plate. Despite being one of the best studied hotspots on Earth, our understanding of the lithospheric discontinuity structure of Hawaiʻi is inhibited by a lack of a long‐term distributed broadband seismic network and lithospheric‐scale imaging of other oceanic hotspots. In this study, we analyze 3,530 teleseismic waveforms from 1,130 events recorded at 47 stations to compute P‐wave radial receiver functions. We then incorporate an elevation correction to adaptive common conversion point stacking to create a 3D discontinuity volume of the lithospheric structure associated with an ocean island hotspot. We find a positive amplitude conversion consistently at ∼12 km below sea level, likely representing the crust‐mantle transition below much of the island. However, this conversion occurs at only ∼6 km below Kīlauea, where local tomography images a zone of high P‐wave velocities (>7 km/s) within the crust and deformation of olivine phenocrysts within a magmatic reservoir is thought to occur. At this location, seismicity also extends vertically to 35 km depth before merging with an interpreted sill complex at ∼40 km. We interpret this anomalously shallow high amplitude discontinuity as an olivine‐dominated magmatic reservoir with an estimated maximum 5% melt over the resolution of our data at crustal depths. This represents the shallow seismic signature of a much more extensive magma system extending to depth. These images provide a better understanding of the magmatic structure associated with oceanic hotspot volcanoes.
Effect of Multiscale Cracks on Seismic Wave Propagation in Tight Sandstones
Authors: Ba Jing , Zhu Hesong , Zhang Lin , Carcione José M. 
Published: October 2023

AbstractSeismic wave propagation is affected by wave‐induced local fluid flow between stiff pores and multiscale fractures. To investigate this phenomenon, forced vibration (1–100 Hz) and ultrasonic (106 Hz) measurements are performed on two tight sandstones with complex pore geometry in dry and water‐saturated scenarios. Porosity, permeability, and ultrasonic velocities were also measured at different differential pressures. The results indicate that the nonlinear behavior of these properties is strongly influenced by the presence of cracks, and the correlations between the permeability/ultrasonic velocities and porosity are different. A wave propagation model is then developed in which penny‐shaped cracks are inclusions introduced stepwise into a porous medium to describe the wave anelasticity in a wide frequency band at different pressures. As a result, the model provides good agreement with the measured P‐wave velocity dispersion, and the pore aspect ratio spectrum and crack radii are determined. We then compare the estimated crack radii and pore size distributions from nuclear magnetic resonance spectroscopy. Published data of a tight sandstone and a low porosity sandstone in the frequency range (2–200, 106) and (1–3,000) Hz at different differential pressures are also analyzed to validate the model. The aspect ratios, volume fractions, and radii of pores/cracks are used to describe the measured permeability. The present work can provide new insights into the geophysical properties of reservoir rocks with complex pore geometry.
Effect of Temperature and Water Droplets on Production of Prodigious Hydrogen Oxides by Electrical Discharges
Authors: Jenkins J. M. , Brune W. H. 
Published: October 2023

AbstractRecently, electrical discharges have been identified as a potentially significant source of the atmosphere's most important oxidant, the hydroxyl radical. Measurements of hydroxyl, the closely related hydroperoxyl radical, and the nitrogen oxides from sparks and subvisible discharges were made in the laboratory under different environmental and electrical conditions representing those found in the troposphere. However, there were still several conditions not yet investigated that could impact hydroxyl and hydroperoxyl production in electrical discharges. In this study, the production of electrically generated hydroxyl and hydroperoxyl (LHOx) and nitrogen oxides (LNOx) was measured under three new conditions not tested previously, including lower pressure, different temperatures, and the presence of cloud droplet‐sized water droplets. In spark discharges, LHOx was mostly independent of pressure, increased with increasing temperature, and was unaffected by the water droplets. LNOx generation was independent of temperature from −10 to 40°C and the presence of water droplets, but increased 1.5‐fold with decreasing pressure. LNOx generation was also found to be sensitive to changes in spark intensity and air flow in the laboratory setup. Increasing temperature also made it more likely that a discharge was visible instead of subvisible, but did not impact LHOx production in subvisible discharges. Even under these new conditions, the laboratory results agree with results of LHOx from a field campaign, demonstrating the relevance of the laboratory experiments to the atmosphere.
Studying the Fixing Rate of GPS PPP Ambiguity Resolution Under Different Geomagnetic Storm Intensities
Authors: Luo Xiaomin , Chen Zhuang , Gu Shengfeng , Yue Neng , Yue Tao 
Published: October 2023

AbstractGlobal Positioning System (GPS) Precise Point Positioning (PPP) with correct fixing ambiguity resolution (AR) can reach cm‐mm level positioning accuracy. However, this accuracy can be degraded by the geomagnetic storm effects. To comprehensively investigate the ambiguity resolved percentage (ARP) of GPS kinematic PPP, referred to as PPP‐ARP, under different intensities of geomagnetic storms, based on the Natural Resources Canada's Canadian Spatial Reference System (CSRS) PPP, this study for the first time gives the correlation between the PPP‐ARP and storm intensity using 67 storms occurred in the past 5 years of 2018–2022. Experimental results indicate that the PPP‐ARP decreases gradually as the increase of geomagnetic storm intensity. Under quiet and low geomagnetic conditions (Dstmin > −50 nT), the PPP‐ARP of global GNSS stations can achieve more than 96%, while these during strong storms (Dstmin ≤ −100 nT) are generally lower than 90.0%, especially for the PPP‐ARP of some stations located at low latitudes which are lower than 40.0%. The mechanism of PPP‐ARP decrease under geomagnetic storms is mainly due to the cycle slips and even loss of lock of GNSS signals caused by the storms induced ionospheric disturbances and scintillations. In addition, different from many previous studies, we found that the CSRS‐PPP with AR can achieve good positioning accuracy (3D RMS <0.2 m) even under strong geomagnetic storms.
Microbial drivers of DMSO reduction and DMS-dependent methanogenesis in saltmarsh sediments
Authors: Tebbe Dennis Alexander , Gruender Charlotte , Dlugosch Leon , Lõhmus Kertu , Rolfes Sönke , Könneke Martin , Chen Yin , Engelen Bert , Schäfer Hendrik 
Published: October 2023

Abstract
Saltmarshes are highly productive environments, exhibiting high abundances of organosulfur compounds. Dimethylsulfoniopropionate (DMSP) is produced in large quantities by algae, plants, and bacteria and is a potential precursor for dimethylsulfoxide (DMSO) and dimethylsulfide (DMS). DMSO serves as electron acceptor for anaerobic respiration leading to DMS formation, which is either emitted or can be degraded by methylotrophic prokaryotes. Major products of these reactions are trace gases with positive (CO2, CH4) or negative (DMS) radiative forcing with contrasting effects on the global climate. Here, we investigated organic sulfur cycling in saltmarsh sediments and followed DMSO reduction in anoxic batch experiments. Compared to previous measurements from marine waters, DMSO concentrations in the saltmarsh sediments were up to ~300 fold higher. In batch experiments, DMSO was reduced to DMS and subsequently consumed with concomitant CH4 production. Changes in prokaryotic communities and DMSO reductase gene counts indicated a dominance of organisms containing the Dms-type DMSO reductases (e.g., Desulfobulbales, Enterobacterales). In contrast, when sulfate reduction was inhibited by molybdate, Tor-type DMSO reductases (e.g., Rhodobacterales) increased. Vibrionales increased in relative abundance in both treatments, and metagenome assembled genomes (MAGs) affiliated to Vibrio had all genes encoding the subunits of DMSO reductases. Molar conversion ratios of &lt;1.3 CH4 per added DMSO were accompanied by a predominance of the methylotrophic methanogens Methanosarcinales. Enrichment of mtsDH genes, encoding for DMS methyl transferases in metagenomes of batch incubations indicate their role in DMS-dependent methanogenesis. MAGs affiliated to Methanolobus carried the complete set of genes encoding for the enzymes in methylotrophic methanogenesis.
Electromagnetic signatures of a chiral quantum spin liquid
Authors: Banerjee Saikat , Zhu Wei , Lin Shi-Zeng 
Published: October 2023

AbstractQuantum spin liquids (QSL) have emerged as a captivating subject within interacting spin systems that exhibit no magnetic ordering even at the lowest temperature accessible experimentally. However, definitive experimental evidence remains elusive. In light of the recent surge in theoretical and experimental interest in the half-filled Hubbard model on a triangular lattice, which offers the potential for stabilizing a chiral QSL, we investigate the electromagnetic signatures of this phase to facilitate experimental detection. Utilizing a combination of parton mean-field theory and unbiased density-matrix renormalization group calculations, we systematically examine the electrical charge and orbital electrical current associated with a spinon excitation in the chiral QSL. Additionally, we calculate the longitudinal and transverse optical conductivities below the Mott gap. Furthermore, employing quantum field theory analysis, we unravel the connection between spinon excitations and emergent as well as physical gauge fields. Our results demonstrate that the chiral QSL phase exhibits a distinct electromagnetic response, even within a Mott insulator regime. This finding holds great potential for enabling the experimental detection of this long-sought-after phase.
Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants
Authors: Mittal Nidhi , Kumar Sahil , Rajmani Raju S. , Singh Randhir , Lemoine Céline , Jakob Virginie , BJ Sowrabha , Jagannath Nayana , Bhat Madhuraj , Chakraborty Debajyoti , Pandey Suman , Jory Aurélie , SA Suba Soundarya , Kleanthous Harry , Dubois Patrice , Ringe Rajesh P. , Varadarajan Raghavan 
Published: October 2023

AbstractWith the rapid emergence of variants of concern (VOC), the efficacy of currently licensed vaccines has reduced drastically. VOC mutations largely occur in the S1 subunit of Spike. The S2 subunit of SARS-CoV-2 is conserved and thus more likely to elicit broadly reactive immune responses that could improve protection. However, the contribution of the S2 subunit in improving the overall efficacy of vaccines remains unclear. Therefore, we designed, and evaluated the immunogenicity and protective potential of a stabilized SARS-CoV-2 Receptor Binding Domain (RBD) fused to a stabilized S2. Immunogens were expressed as soluble proteins with approximately fivefold higher purified yield than the Spike ectodomain and formulated along with Squalene-in-water emulsion (SWE) adjuvant. Immunization with S2 alone failed to elicit a neutralizing immune response, but significantly reduced lung viral titers in mice challenged with the heterologous Beta variant. In hamsters, SWE-formulated RS2 (a genetic fusion of stabilized RBD with S2) showed enhanced immunogenicity and efficacy relative to corresponding RBD and Spike formulations. Despite being based on the ancestral Wuhan strain of SARS-CoV-2, RS2 elicited broad neutralization, including against Omicron variants (BA.1, BA.5 and BF.7), and the clade 1a WIV-1 and SARS-CoV-1 strains. RS2 elicited sera showed enhanced competition with both S2 directed and RBD Class 4 directed broadly neutralizing antibodies, relative to RBD and Spike elicited sera. When lyophilized, RS2 retained antigenicity and immunogenicity even after incubation at 37 °C for a month. The data collectively suggest that the RS2 immunogen is a promising modality to combat SARS-CoV-2 variants.
Hemoglobin signal network mapping reveals novel indicators for precision medicine
Authors: Barbour Randall L. , Graber Harry L. 
Published: October 2023

AbstractPrecision medicine currently relies on a mix of deep phenotyping strategies to guide more individualized healthcare. Despite being widely available and information-rich, physiological time-series measures are often overlooked as a resource to extend insights gained from such measures. Here we have explored resting-state hemoglobin measures applied to intact whole breasts for two subject groups – women with confirmed breast cancer and control subjects – with the goal of achieving a more detailed assessment of the cancer phenotype from a non-invasive measure. Invoked is a novel ordinal partition network method applied to multivariate measures that generates a Markov chain, thereby providing access to quantitative descriptions of short-term dynamics in the form of several classes of adjacency matrices. Exploration of these and their associated co-dependent behaviors unexpectedly reveals features of structured dynamics, some of which are shown to exhibit enzyme-like behaviors and sensitivity to recognized molecular markers of disease. Thus, findings obtained strongly indicate that despite the use of a macroscale sensing method, features more typical of molecular-cellular processes can be identified. Discussed are factors unique to our approach that favor a deeper depiction of tissue phenotypes, its extension to other forms of physiological time-series measures, and its expected utility to advance goals of precision medicine.
Continuous short-term acclimation to moderate cold elicits cardioprotection in rats, and alters β-adrenergic signaling and immune status
Authors: Marvanova Aneta , Kasik Petr , Elsnicova Barbara , Tibenska Veronika , Galatik František , Hornikova Daniela , Zvolska Veronika , Vebr Pavel , Vodicka Petr , Hejnova Lucie , Matous Petr , Szeiff Bacova Barbara , Sykora Matus , Novotny Jiri , Neuzil Jiri , Kolar Frantisek , Novakova Olga , Zurmanova Jitka M. 
Published: October 2023

AbstractModerate cold acclimation (MCA) is a non-invasive intervention mitigating effects of various pathological conditions including myocardial infarction. We aim to determine the shortest cardioprotective regimen of MCA and the response of β1/2/3-adrenoceptors (β-AR), its downstream signaling, and inflammatory status, which play a role in cell-survival during myocardial infarction. Adult male Wistar rats were acclimated (9 °C, 1–3-10 days). Infarct size, echocardiography, western blotting, ELISA, mitochondrial respirometry, receptor binding assay, and quantitative immunofluorescence microscopy were carried out on left ventricular myocardium and brown adipose tissue (BAT). MultiPlex analysis of cytokines and chemokines in serum was accomplished. We found that short-term MCA reduced myocardial infarction, improved resistance of mitochondria to Ca2+-overload, and downregulated β1-ARs. The β2-ARs/protein kinase B/Akt were attenuated while β3-ARs translocated on the T-tubular system suggesting its activation. Protein kinase G (PKG) translocated to sarcoplasmic reticulum and phosphorylation of AMPKThr172 increased after 10 days. Principal component analysis revealed a significant shift in cytokine/chemokine serum levels on day 10 of acclimation, which corresponds to maturation of BAT. In conclusion, short-term MCA increases heart resilience to ischemia without any negative side effects such as hypertension or hypertrophy. Cold-elicited cardioprotection is accompanied by β1/2-AR desensitization, activation of the β3-AR/PKG/AMPK pathways, and an immunomodulatory effect.
PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish
Authors: Kim Minwook , So Juhoon , Shin Donghun 
Published: October 2023

AbstractDespite the robust regenerative capacity of the liver, prolonged and severe liver damage impairs liver regeneration, leading to liver failure. Since the liver co-opts the differentiation of liver progenitor cells (LPCs) into hepatocytes to restore functional hepatocytes, augmenting LPC-mediated liver regeneration may be beneficial to patients with chronic liver diseases. However, the molecular mechanisms underlying LPC-to-hepatocyte differentiation have remained largely unknown. Using the zebrafish model of LPC-mediated liver regeneration, Tg(fabp10a:pt-β-catenin), we present that peroxisome proliferator-activated receptor-alpha (PPARα) activation augments LPC-to-hepatocyte differentiation. We found that treating Tg(fabp10a:pt-β-catenin) larvae with GW7647, a potent PPARα agonist, enhanced the expression of hepatocyte markers and simultaneously reduced the expression of biliary epithelial cell (BEC)/LPC markers in the regenerating livers, indicating enhanced LPC-to-hepatocyte differentiation. Mechanistically, PPARα activation augments the differentiation by suppressing YAP signaling. The differentiation phenotypes resulting from GW7647 treatment were rescued by expressing a constitutively active form of Yap1. Moreover, we found that suppression of YAP signaling was sufficient to promote LPC-to-hepatocyte differentiation. Treating Tg(fabp10a:pt-β-catenin) larvae with the TEAD inhibitor K-975, which suppresses YAP signaling, phenocopied the effect of GW7647 on LPC differentiation. Altogether, our findings provide insights into augmenting LPC-mediated liver regeneration as a regenerative therapy for chronic liver diseases.