bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical transmission of Trypanosoma evansi in a dromedary camel calf that spontaneously recovered after colostrum consumption
Authors: Nasef Mostafa , Dioli Maurizio , Gupta Aungshuman Das 
Published: December 2023

AbstractA weak dromedary calf with signs of prematurity was born in April of 2023 to a healthy multiparous camel with a good body condition. The calf was diagnosed strongly positive to Trypanosoma evansi by haematocrit centrifugation technique (immediately after birth). The mother at that time was asymptomatic and negative by haematocrit centrifugation technique and PCR of blood. Indirect ELISA of the calf's serum before colostrum ingestion showed negligible levels of antibodies. However, 12 hours after colostrum ingestion and without any treatment, the levels of antibodies increased significantly, which coincided with negative haematocrit centrifugation technique. This indicates a possible role of colostral antibodies in neutralising the trypanosomes in the calf's blood. Examination of the placenta showed placentitis, and PCR confirmed a positive result for Trypanosoma nucleic acid. The importance of vertical transmission in maintaining the infection in a herd is discussed, as well as the role of colostrum in decreasing calf mortalities due to trypanosomosis.
GetPrimers: A generalized PCR‐based genetic targeting primer designer enabling easy and standardized targeted gene modification across multiple systems
Authors: Miao Zepu , Wang Haiting , Tu Xinyu , Huang Zhengshen , Huang Shujing , Zhang Xinxin , Wang Fan , Huang Zhishen , Li Huihui , Jiao Yue , Gao Song , Zhou Zhipeng , Shan Chun‐Min , Li Jing , Yue Jia‐Xing 
Published: December 2023

AbstractGenetic targeting (e.g., gene knockout and tagging) based on polymerase chain reaction (PCR) is a simple yet powerful approach for studying gene functions. Although originally developed in classic budding and fission yeast models, the same principle applies to other eukaryotic systems with efficient homologous recombination. One‐step PCR‐based genetic targeting is conventionally used but the sizes of the homologous arms that it generates for recombination‐mediated genetic targeting are usually limited. Alternatively, gene targeting can also be performed via fusion PCR, which can create homologous arms that are orders of magnitude larger, therefore substantially increasing the efficiency of recombination‐mediated genetic targeting. Here, we present GetPrimers (https://www.evomicslab.org/app/getprimers/), a generalized computational framework and web tool to assist automatic targeting and verification primer design for both one‐step PCR‐based and fusion PCR‐based genetic targeting experiments. Moreover, GetPrimers by design runs for any given genetic background of any species with full genome scalability. Therefore, GetPrimers is capable of empowering high‐throughput functional genomic assays at multipopulation and multispecies levels. Comprehensive experimental validations have been performed for targeting and verification primers designed by GetPrimers across multiple organism systems and experimental setups. We anticipate GetPrimers to become a highly useful and popular tool to facilitate easy and standardized gene modification across multiple systems.
Designing Interrogative Robot Theater: A Robot Who Won’t Take No for an Answer
Authors: Sajadieh Sahar , Wolfe Hannen 
Published: December 2023

Abstract“You are the hottest thing in the room! I couldn’t help but come over to introduce myself.” That’s how the conversation began between the human-sized female robot and an audience member in a corner of the room duringCome Hither to Me!In this robot theater the robotic agent charms the audience with her seductive humor and subtly enters them into a provocative dialogue that surfaces their stereotypical biases in gendered social interactions.Come Hither to Me!exemplifies “Interrogative Robot Theater,” our performative and critical method for social robotics research with an objective of designing robotic embodiment and interactivity for theatrical performances and public interventions. We apply various design and theater-making methods to develop a socially engaging, fun, and playful interactive experience for the audience. Using humorous conversation and embodied interaction design, our feminist robot theater makes a satirical performative commentary on misogynist dating culture and stereotypical gender roles. Inspired by the male-centered pickup artist community guidelines, we designed a chatbot decision tree for our female-gendered robot actor that flirts and provokes conversation with participants of all genders, subverting the imbalanced power dynamics of sexist social interactions. This interventionist theater-making methodology builds upon social justice-oriented interaction design, interrogative design, and Theater of the Oppressed. Through the application of this approach,Come Hither to Me!interrogates and problematizes gendered intimacy and agency in social interactions.
Community Question: Classical Debates
Authors: Klekotko Marta 
Published: December 2023

AbstractThe chapter provides an overview of the classical debates on community question. It discusses various approaches to community, comprehended as a neighbourhood, a network or a sense of belonging. In the introduction to the chapter, an overview of the concept of community as opposed to city is presented and the nature of the community question is explained. The introduction is followed by the presentation of the concepts supporting the “community saved” hypothesis and provides the details on the classical approach to the urban community as a neighbourhood as well as discusses contemporary approaches to community comprehended as a place-based social ties. Next, the chapter provides details on the “community liberated” hypothesis and discusses a variety of concepts of community comprehended as a network and a sense of belonging. The chapter concludes with the statement that there is a conceptual gap in the community studies that reflects the “agency vs structure” division. It presents some attempts to overcome them, paying particular attention to Talia Blokland’s concept of community as urban practice, and points to the need for the development of a new approach that would overcome the shortcomings of the current approaches to community and would allow for exploration of the phenomena that have remained so far out of view of community studies.
Analyse von Untergrundkomponenten
Authors: Richter Simon , Lubashevsky Katrin , Randow Jakob , Henker Steve , Zschoke H. Konstanze , Bucher Anke 
Published: December 2023

ZusammenfassungDie Gegebenheiten im geologischen Untergrund und vor allem die dort vorhandenen Temperaturbedingungen sind die zentrale Ressource, der sich geothermische Anlagen bedienen. Die große Bedeutung, die den Informationen zu den Gegebenheiten im Untergrund im Planungsprozess solcher Anlagen zukommt, ist daher naheliegend. Eine möglichst genaue Kenntnis der Bedingungen ermöglicht eine bessere und effizientere Auslegung. Um die Kenntnis über Eigenschaften von Untergrundkomponenten und die Nutzung von Informationen aus dem Untergrund für Planungsprozesse zu verbessern, wurden in EASyQuart einige Untersuchungen durchgeführt. Hierzu zählen Sensitivitätsanalysen, numerische Unsicherheitsanalysen und potenzielle Optimierungsstrategien, welche in diesem Kapitel vorgestellt werden.
Benchmarks
Authors: Richter Simon , Randow Jakob , Shao Haibing , Lubashevsky Katrin , Henker Steve , Bucher Anke 
Published: December 2023

ZusammenfassungIn diesem Kapitel werden die im Rahmen von EASyQuart entwickelten Anwendungsbeispiele (Benchmarks) für OpenGeoSys (OGS) kurz vorgestellt. Diese Benchmarks betrachten beispielhaft Möglichkeiten der Simulation mit OGS und dienen auch der Qualitätssicherung in der Code-Entwicklung der Simulationsplattform. Im Speziellen werden drei Benchmarks vorgestellt.
Systemintegration
Authors: Rink Karsten , Grimm Rüdiger , Hastreiter Nele , Kroll Paula , Remmler Paul , Shao Haibing , Zschoke H. Konstanze 
Published: December 2023

ZusammenfassungNachdem in den vergangenen Kapiteln ausführlich die Abläufe bei der Erkundung, dem Monitoring sowie der Simulation des Untergrundes und der Haustechnik beschrieben wurden, werden nun in Abschn. 7.1 Möglichkeiten zur Verwendung der erhobenen und generierten Daten für die Entwicklung eines prototypischen Informationssystems dargestellt. Die Nutzung der gewonnenen Erkenntnisse für die Gestaltung eines Entscheidungshilfesystems wird in Abschn. 7.2 für den gesamten Prozess von der Grundlagenplanung und Machbarkeitsprüfung über die einzelnen Planungs- und Genehmigungsschritte bis zur Objektbetreuung nach der Implementation beschrieben. Abschn. 7.3 zeigt auf, in welchem Maße sich gesetzliche Vorgaben derzeit für die Anlagenplanung in Deutschland zwischen den einzelnen Bundesländern unterscheiden und gibt Empfehlungen zur Anpassung ebendieser regulativen Rahmenbedingungen.
Fazit und Ausblick
Authors: Randow Jakob , Bucher Anke , Görke Uwe-Jens , Grimm Rüdiger , Hastreiter Nele , Kolditz Olaf , Lubashevsky Katrin , Richter Simon , Rink Karsten , Schönfelder Stephan , Shao Haibing , Vienken Thomas , Zschoke H. Konstanze 
Published: December 2023

ZusammenfassungEin wesentlicher Teil des Innovationsgehalts von EASyQuart besteht darin, offene wissenschaftliche Fragestellungen bei der Optimierung großflächiger oberflächennaher Geothermienetzwerke klären zu helfen (z. B. durch Anpassung, Entwicklung und Bewertung standort- und prozessbezogener Erkundungs- und Monitoringverfahren, Sensitivitätsstudien, numerische Unsicherheitsanalysen sowie gekoppelte Simulationen des Gesamtsystems Untergrund-Haustechnik). Zudem wurden exemplarisch konkrete Prognoseinstrumentarien zur standortbasierten Analyse der Versorgungs- und Bedarfsseite für verschiedene Arbeitsschritte eines Auslegungs- und Planungsprozesses oberflächennaher geothermischer Anlagen zum Heizen und Kühlen erstellt und mit Daten realer Standorte validiert. Auf dieser Basis konnten vom Verbundvorhaben Empfehlungen für die Flexibilisierung von Auslegungsverfahren und regulativen Rahmenbedingungen für Errichtung und Betrieb der betrachteten Systeme formuliert werden.
Universality of loop corrected soft theorems in 4d
Authors: Krishna Hare , Sahoo Biswajit 
Published: December 2023

Abstract
In [1], logarithmic correction to subleading soft photon and soft graviton theorems have been derived in four spacetime dimensions from the ratio of IR-finite S-matrices. This has been achieved after factoring out IR-divergent components from the traditional electromagnetic and gravitational S-matrices using Grammer-Yennie prescription. Although the loop corrected subleading soft theorems are derived from one-loop scattering amplitudes involving scalar particles in a minimally coupled theory with scalar contact interaction, it has been conjectured that the soft factors are universal (theory independent) and one-loop exact (don’t receive corrections from higher loops).This paper extends the analysis conducted in [1] to encompass general spinning particle scattering with non-minimal couplings permitted by gauge invariance and general coordinate invariance. By re-deriving the ln ω soft factors in this generic setup, we establish their universal nature. Furthermore, we summarize the results of loop corrected soft photon and graviton theorems up to sub-subleading order, which follows from the analysis of one and two loop QED and quantum gravity S-matrices. While the classical versions of these soft factors have already been derived in the literature, we put forth conjectures regarding the quantum soft factors and outline potential strategies for their derivation.
Searching for heavy leptophilic Z′: from lepton colliders to gravitational waves
Authors: Dasgupta Arnab , Dev P. S. Bhupal , Han Tao , Padhan Rojalin , Wang Si , Xie Keping 
Published: December 2023

Abstract
We study the phenomenology of leptophilic Z′ gauge bosons at the future high-energy e+e− and μ+μ− colliders, as well as at the gravitational wave observatories. The leptophilic Z′ model, although well-motivated, remains largely unconstrained from current low-energy and collider searches for Z′ masses above $$ \mathcal{O} $$
O
(100 GeV), thus providing a unique opportunity for future lepton colliders. Taking $$ \textrm{U}{(1)}_{L_{\alpha }-{L}_{\beta }} $$
U

1

L
α

−

L
β

(α, β = e, μ, τ) models as concrete examples, we show that future e+e− and μ+μ− colliders with multi-TeV center-of-mass energies provide unprecedented sensitivity to heavy leptophilic Z′ bosons. Moreover, if these U(1) models are classically scale-invariant, the phase transition at the U(1) symmetry-breaking scale tends to be strongly first-order with ultra-supercooling, and leads to observable stochastic gravitational wave signatures. We find that the future sensitivity of gravitational wave observatories, such as advanced LIGO-VIRGO and Cosmic Explorer, can be complementary to the collider experiments, probing higher Z′ masses up to $$ \mathcal{O} $$
O
(104 TeV), while being consistent with naturalness and perturbativity considerations.
Flavour constraints on light spin-1 bosons within a chiral Lagrangian approach
Authors: Di Luzio Luca , Levati Gabriele , Paradisi Paride , Díaz Xavier Ponce 
Published: December 2023

Abstract
We discuss the construction of the chiral Lagrangian for a light spin-1 boson, here denoted as X, featuring both vector and axial-vector couplings to light u, d, s quarks. Focusing on ∆S = 1 transitions, we show that there are model-independent tree-level contributions to K±→ π±X, sourced by Standard Model charged currents, which receive an $$ {m}_K^2/{m}_X^2 $$

m
K
2

/

m
X
2

enhancement from the emission of a longitudinally polarized X. This flavour observable sets the strongest to date model-independent bound on the diagonal axial-vector couplings of X to u, d, s quarks for mX< mK– mπ, superseding the bounds arising from beam-dump and collider searches.
Cortical bone thickness on preoperative CT scans as predictor of bone quality in distal femur fractures: a retrospective study in Caucasians
Authors: Huppke Calvin M. , Fahlbusch Hendrik , Frosch Karl-Heinz , Krause Matthias , von Rehlingen-Prinz Fidelius 
Published: December 2023

Abstract
Aim
Distal femur fractures (DFF) are rare, but associated with high complication rates and mortality, particularly in patients with osteoporosis. To improve preoperative assessment, we analyzed if cortical bone thickness on CT and AP radiographs is associated with clinical parameters of bone quality.

Methods
Retrospective single-center study of adult patients presenting at a level-one trauma center, with a DFF between 2011 and 2020. Clinical parameters for bone quality, such as age, sex, body mass index (BMI), energy impact level of trauma, and known history of osteoporosis, were assessed. Mean cortical bone thickness (CBTavg) on AP radiograph was determined using a previously published method. Cortical thickness on CT scan was measured at 8 and 14 cm proximal to the articular surface of the lateral condyle.

Results
71 patients (46 females) between 20 and 100 years were included in the study. Cortical thickness determined by CT correlated significantly with CBTavg measurements on AP radiograph (Spearman r = 0.62 to 0.80; p < 0.001). Cortical thickness was inversely correlated with age (Spearman r = − 0.341 to − 0.466; p < 0.001) and significantly associated with trauma impact level and history of osteoporosis (p =  < 0.001). The CT-based values showed a stronger correlation with the clinical parameters than those determined by AP X-ray.

Conclusion
Our results showed that cortical thickness of the distal femur correlates with clinical parameters of bone quality and is therefore an excellent tool for assessing what surgical care should be provided. Interestingly, our findings indicate that cortical thickness on CT is more strongly correlated with clinical data than AP radiograph measurements.
Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models
Authors: Mthembu Sinenhlanhla X. H. , Mazibuko-Mbeje Sithandiwe E. , Ziqubu Khanyisani , Muvhulawa Ndivhuwo , Marcheggiani Fabio , Cirilli Ilenia , Nkambule Bongani B. , Muller Christo J. F. , Basson Albertus K. , Tiano Luca , Dludla Phiwayinkosi V. 
Published: December 2023

AbstractHigh-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. Peroxisome proliferator–activated receptor γ coactivator-1α (PGC-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to HFD feeding. Here, some of the major electronic databases like PubMed, Embase, and Web of Science were accessed to update and critically discuss information on the potential role of PGC-1α during metabolic adaptations within the skeletal muscle in response to HFD feeding in rodents. In fact, available evidence suggests that partial exposure to HFD feeding (potentially during the early stages of disease development) is associated with impaired metabolic adaptations within the skeletal muscle, including mitochondrial dysfunction and reduced insulin sensitivity. In terms of implicated molecular mechanisms, these negative effects are partially associated with reduced activity of PGC-1α, together with the phosphorylation of protein kinase B and altered expression of genes involving nuclear respiratory factor 1 and mitochondrial transcription factor A within the skeletal muscle. Notably, metabolic abnormalities observed with chronic exposure to HFD (likely during the late stages of disease development) may potentially occur independently of PGC-1α regulation within the muscle of rodents. Summarized evidence suggests the causal relationship between PGC-1α regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development. It further indicates that prominent interventions like caloric restriction and physical exercise may affect PGC-1α regulation during effective modulation of metabolic processes.
Robust DTW-based entropy fuzzy clustering of time series
Authors: D’Urso Pierpaolo , De Giovanni Livia , Vitale Vincenzina 
Published: December 2023

AbstractTime series are complex data objects whose partitioning into homogeneous groups is still a challenging task, especially in the presence of outliers or noisy data. To address the problem of robustness against outliers in clustering techniques, this paper proposes a robust fuzzy C-medoids method based on entropy regularization. In-depth, we use an appropriate exponential transformation of the dissimilarity based on Dynamic Time Warping, which can be computed also for time series of different length. In addition, the fuzzy framework provides the necessary flexibility to cope with the complexity of the features space. It allows a time series to be assigned to more than one group, considering potential switching behaviours. Moreover, the use of a medoids-based approach enables the identification of observed representative objects within the dataset, thus enhancing interpretability for practical applications. Through an extensive simulation study, we successfully demonstrate the effectiveness of our proposal, comparing and emphasizing its strengths. Finally, our proposed methodology is applied to the daily mean concentrations of three air pollutants in 2022 in the Province of Rome. This application highlights its potential, namely the capability to intercept outliers and switching time series while preserving group structures.
School-to-work transition: putting non-cognitive skills in context. The case of NEET and suggestions for policy
Authors: Ripamonti Enrico 
Published: December 2023

AbstractNEETs represent a category at risk for social exclusion and may show poor non-cognitive skills. In this review we target this issue, taking the contemporary theory of skills formation as a theoretical framework. Intrapersonal agency and motivational components, including educational aspirations, goal attainability, and investing in active efforts are protective factors for a successful school-to-work transition. Having an internal locus of control may help teenagers but might not compensate for a low socioeconomic status. Experiencing high-quality apprenticeships and internships could help teenagers find their vocational specificity. Large-scale intervention programs, promoting investment in human agency and motivation constitute a proper policy strategy.
Flourishing while withering: an explication and critique of Simone de Beauvoir’s phenomenology of aging
Authors: Svenaeus Fredrik 
Published: December 2023

AbstractThis paper explores the process of aging from a phenomenological perspective. Supplementing the model of becoming old found in Simone de Beauvoir’s work with a phenomenology of human suffering and flourishing, it asks whether it is possible to lead a good life in the process of becoming old. Is it possible to flourish while experiencing bodily waning? Is it possible to flourish while experiencing the shrinking of one’s everyday world and the passing away of close others? Aging, at least in its protracted phases, appears to become full of suffering rather than flourishing. What are the prospects of finding meaningful life projects despite old age? By making use of insight found in Heidegger and other phenomenologists the paper tries to develop a slightly different view on aging than the one found in Beauvoir, stressing the importance of embodied experiences and life choices, which not only depend upon societal oppression and being objectified by others, but also upon processes of nature and the possibilities of an intergenerational intersubjectivity. Resources for this project is found in the philosophy of affectivity developed by Heidegger and other phenomenologists of facticity, such as Maurice Merleau-Ponty, Charles Taylor, Helmuth Plessner and Hannah Arendt.
Argumentation-induced rational issue polarisation
Authors: Kopecky Felix 
Published: December 2023

AbstractComputational models have shown how polarisation can rise among deliberating agents as they approximate epistemic rationality. This paper provides further support for the thesis that polarisation can rise under condition of epistemic rationality, but it does not depend on limitations that extant models rely on, such as memory restrictions or biased evaluation of other agents’ testimony. Instead, deliberation is modelled through agents’ purposeful introduction of arguments and their rational reactions to introductions of others. This process induces polarisation dynamics on its own. A second result is that the effect size of polarisation dynamics correlates with particular types of argumentative behaviour. Polarisation effects can be soothed when agents take into account the opinions of others as premises, and they are amplified as agents fortify their own beliefs. These results underpin the relevance of argumentation as a factor in social-epistemic processes and indicate that rising issue polarisation is not a reliable indicator of epistemic shortcomings.