bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holographic imaging of an array of submicron light scatterers at low photon numbers
Authors: Kölle Sebastian , Jäger Manuel , Müller Markus , Schoch Wladimir , Limmer Wolfgang , Denschlag Johannes Hecker 
Published: October 2023

AbstractWe experimentally test a recently proposed holographic method for imaging coherent light scatterers which are distributed over a two-dimensional grid. In our setup, the scatterers consist of a back-illuminated, opaque mask with submicron-sized holes. We study how the imaging fidelity depends on various parameters of the set-up. We observe that a few hundred scattered photons per hole already suffice to obtain a fidelity of 96% to correctly determine whether a hole is located at a given grid point. The holographic method demonstrated here has a high potential for applications with ultracold atoms in optical lattices.
Biomarkers predictive of a response to extended endocrine therapy in breast cancer: a systematic review and meta-analysis
Authors: Woolpert Kirsten M. , Ahern Thomas P. , Lash Timothy L. , O’Malley Donna L. , Stokes Alice M. , Cronin-Fenton Deirdre P. 
Published: October 2023

Abstract
Purpose
Extension of adjuvant endocrine therapy beyond five years confers only modest survival benefit in breast cancer patients and carries risk of toxicities. This systematic review investigates the role of biomarker tests in predicting the clinical response to an extension of endocrine therapy.

Methods
We searched Ovid MEDLINE, Ovid Embase, Global Index Medicus, and the Cochrane Central Register of Controlled Trials using an iterative approach to identify full-text articles related to breast cancer, endocrine therapy, and biomarkers.

Results
Of the 1,217 unique reports identified, five studies were deemed eligible. Four investigated the Breast Cancer Index (BCI) assay in three distinct study populations. These studies consistently showed that BCI score was predictive of response to extended endocrine therapy among 1,946 combined patients, who were predominately non-Hispanic white and postmenopausal.

Conclusions
Evidence in the setting of predictive tests for extended endocrine therapy is sparse. Most relevant studies investigated the use of BCI, but these study populations were largely restricted to a single age, race, and ethnicity group. Future studies should evaluate a variety of biomarkers in diverse populations. Without sufficient evidence, physicians and patients face a difficult decision in balancing the benefits and risks of endocrine therapy extension.
Prostate-specific antigen testing rates in high-risk populations: results from the All of Us Research Program
Authors: Morley Faith , Iyer Hari S. , Tamimi Rulla M. , Nanus David M. , Rebbeck Timothy R. , Kensler Kevin H. 
Published: October 2023

Abstract
Background
Early detection of prostate cancer using prostate-specific antigen (PSA) remains controversial and disparities in the receipt of prostate cancer screening persist in the US. We sought to examine disparities in PSA testing rates among groups with higher prostate cancer risk and differential access to healthcare.

Methods
We identified a cohort of 37,706 males within the All of Us Research Program without a history of prostate cancer between the ages of 40 and 85 at time of enrollment (2017–2021). Incidence rate ratios (IRR) for the number of PSA tests received during follow-up through December 2021 were estimated using age- and multivariable-adjusted negative binomial regression models. PSA testing frequencies in the cohort were compared with population-based estimates from the 2020 Behavioral Risk Factor Surveillance System (BRFSS).

Results
A total of 6,486 males (17.2%) received at least one PSA test over the course of follow-up. In multivariable-adjusted models, non-Hispanic Black males received PSA tests at a 17% lower rate (IRR = 0.83, 95% CI 0.76, 0.90) than non-Hispanic White males. Higher educational attainment, higher annual income, having self-/employer-purchased insurance, having a spouse or domestic partner, and having a family history of prostate cancer were all associated with higher rates of PSA testing. The proportion of males ages 55 to 69 who received a PSA test within two years was lower in All of Us (12.4%, 95% CI 11.8–13.0%) relative to population-based estimates from the BRFSS (35.2%, 95% CI 34.2–36.3%).

Conclusion
Absolute PSA testing rates in All of Us were lower than population-based estimates, but associations with PSA testing in the cohort mirrored previously reported disparities in prostate cancer screening. These findings highlight the importance of addressing barriers to care in order to reduce disparities in cancer screening.
Modularity impacts cellulose surface oxidation by a lytic polysaccharide monooxygenase from Streptomyces coelicolor
Authors: Raji Olanrewaju , Eijsink Vincent G. H. , Master Emma , Forsberg Zarah 
Published: October 2023

AbstractLytic polysaccharide monooxygenases (LPMOs) catalyze the oxidation of β-(1,4)-linked polysaccharides, such as cellulose, in a reaction that requires an electron donor and H2O2 as co-substrate. Several LPMOs include a carbohydrate-binding module (CBM), which promotes action on insoluble substrates. Herein, a fluorescent labeling technique was used to track LPMO action on microcrystalline cellulose and evaluate the impact of CBMs on the distribution of LPMO activity across the fiber surface. Confocal microscopic images revealed that the distribution of oxidized positions on the cellulose surface was CBM-dependent: fluorescent spots were concentrated in reactions with a CBM-containing LPMO whereas they were more dispersed for a CBM-deficient LPMO variant. The more dispersed oxidation pattern for the CBM-free LPMO coincided with the release of fewer soluble reaction products.
A fast continuous time approach for non-smooth convex optimization using Tikhonov regularization technique
Authors: Karapetyants Mikhail A. 
Published: October 2023

AbstractIn this paper we would like to address the classical optimization problem of minimizing a proper, convex and lower semicontinuous function via the second order in time dynamics, combining viscous and Hessian-driven damping with a Tikhonov regularization term. In our analysis we heavily exploit the Moreau envelope of the objective function and its properties as well as Tikhonov regularization properties, which we extend to a nonsmooth case. We introduce the setting, which at the same time guarantees the fast convergence of the function (and Moreau envelope) values and strong convergence of the trajectories of the system to a minimal norm solution—the element of the minimal norm of all the minimizers of the objective. Moreover, we deduce the precise rates of convergence of the values for the particular choice of parameters. Various numerical examples are also included as an illustration of the theoretical results.
Medical students' perceptions of a novel international adaptive progress test
Authors: Kisielewska Jolanta , Millin Paul , Rice Neil , Pego Jose Miguel , Burr Steven , Nowakowski Michal , Gale Thomas 
Published: October 2023

AbstractBetween 2018–2021, eight European medical schools took part in a study to develop a medical knowledge Online Adaptive International Progress Test. Here we discuss participants’ self-perception to evaluate the acceptability of adaptive vs non-adaptive testing. Study participants, students from across Europe at all stages of undergraduate medical education with varying levels of prior experience with progress testing, sat remotely invigilated tests using the online QuizOne® platform. Participants completed online feedback questionnaires on their experiences and perceptions of adaptive and non-adaptive tests. Overall satisfaction with the organisation and delivery of remote online tests was high regardless of previous experience with progress testing, differences in stages, programmes, and to some degree language. In statements probing the appropriateness of the level and the length of testing, differences were observed between adaptive and non-adaptive tests. There was a high level of agreement that the adaptive test was a good measure of personal knowledge and increased participants’ motivation for study. Students’ self-perception of the assessment is an important factor in evaluation of acceptability of the exam and its further development. In our study, the adaptive test algorithm adjusted the level of difficulty for the individual student in real-time, leading to positive perceptions of the length of the test and promoting students’ engagement. The assessment increases student motivation for learning and in turn, has the potential to improve their performance.
Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents
Authors: Dugré Jules Roger , Potvin Stéphane 
Published: October 2023

AbstractA large body of literature suggests that the primary (high callousness-unemotional traits [CU] and low anxiety) and secondary (high CU traits and anxiety) variants of psychopathy significantly differ in terms of their clinical profiles. However, little is known about their neurobiological differences. While few studies showed that variants differ in brain activity during fear processing, it remains unknown whether they also show atypical functioning in motivational and reward system. Latent Profile Analysis (LPA) was conducted on a large sample of adolescents (n = 1416) to identify variants based on their levels of callousness and anxiety. Seed-to-voxel connectivity analysis was subsequently performed on resting-state fMRI data to compare connectivity patterns of the nucleus accumbens across subgroups. LPA failed to identify the primary variant when using total score of CU traits. Using a family-wise cluster correction, groups did not differ on functional connectivity. However, at an uncorrected threshold the secondary variant showed distinct functional connectivity between the nucleus accumbens and posterior insula, lateral orbitofrontal cortex, supplementary motor area, and parietal regions. Secondary LPA analysis using only the callousness subscale successfully distinguish both variants. Group differences replicated results of deficits in functional connectivity between the nucleus accumbens and posterior insula and supplementary motor area, but additionally showed effect in the superior temporal gyrus which was specific to the primary variant. The current study supports the importance of examining the neurobiological markers across subgroups of adolescents at risk for conduct problems to precise our understanding of this heterogeneous population.
Triangulation of Questionnaires, Qualitative Data and Natural Language Processing: A Differential Approach to Religious Bahá’í Fasting in Germany
Authors: Steckhan Nico , Ring Raphaela , Borchert Florian , Koppold Daniela A. 
Published: October 2023

Abstract
Approaches to integrating mixed methods into medical research are gaining popularity. To get a holistic understanding of the effects of behavioural interventions, we investigated religious fasting using a triangulation of quantitative, qualitative, and natural language analysis. We analysed an observational study of Bahá'í fasting in Germany using a between-method triangulation that is based on links between qualitative and quantitative analyses. Individual interviews show an increase in the mindfulness and well-being categories. Sentiment scores, extracted from the interviews through natural language processing, positively correlate with questionnaire outcomes on quality of life (WHO-5: Spearman correlation r = 0.486, p = 0.048). Five questionnaires contribute to the first principal component capturing the spectrum of mood states (50.1% explained variance). Integrating the findings of the between-method triangulation enabled us to converge on the underlying effects of this kind of intermittent fasting.

Trial registration
NCT03443739
An Online CURE Taught at a Community College During the Pandemic Shows Mixed Results for Development of Research Self-Efficacy and In-class Relationships
Authors: Dunbar-Wallis Amy , Katcher Jennifer , Moore Wendy , Corwin Lisa A. 
Published: October 2023

AbstractThe Bee the CURE is a novel course-based undergraduate research experience (CURE) that engages introductory biology students in DNA barcoding (DNA extraction, amplification, and bioinformatics) in partnership with the Tucson Bee Collaborative and the University of Arizona. The first iteration of this CURE taught at Pima Community College (PCC) occurred during the Fall 2020 semester in which the course was taught online and students focused on bioinformatics. Due to the online format, students were unable to participate directly in the wet-lab components (extraction and amplification) of the course. These were approximated with videos of the instructor performing the tasks. A qualitative case study of this semester built from student interviews found that students were able to form positive relationships with instructors and peer mentors but that the online format of the class posed some challenges to relationship formation. Students reported developing self-efficacy in bioinformatics skills while online lab participation disrupted student’s gaining “hands-on experiences” and seldom led to development of science self-efficacy in wet lab skills. Our findings from a study of a synchronous online CURE allowed us to characterize a context in which online learning posed a challenge and perhaps even a threat to research self-efficacy, especially regarding skill development and self-efficacy in “hands-on” areas, such as wet-bench research skills. Yet optimistically, our study highlights the potential of online community college learning environments to provide mastery experiences in online science contexts (e.g., bioinformatics) and opportunities for relationship building.
Optimization of Sparsity-Constrained Neural Networks as a Mixed Integer Linear Program
Authors: Rosenhahn Bodo 
Published: October 2023

AbstractThe literature has shown how to optimize and analyze the parameters of different types of neural networks using mixed integer linear programs (MILP). Building on these developments, this work presents an approach to do so for a McCulloch/Pitts and Rosenblatt neurons. As the original formulation involves a step-function, it is not differentiable, but it is possible to optimize the parameters of neurons, and their concatenation as a shallow neural network, by using a mixed integer linear program. The main contribution of this paper is to additionally enforce sparsity constraints on the weights and activations as well as on the amount of used neurons. Several experiments demonstrate that such constraints effectively prevent overfitting in neural networks, and ensure resource optimized models.
Silver/polydopamine/HMX nanocomposite: novel functionalized catalyzed energetic matrix with superior decomposition kinetics
Authors: Elbasuney Sherif , Ismael Shukri , Yehia M. , Saleh Ahmed 
Published: October 2023

AbstractSurface engineering of energetic materials can secure novel decomposition characteristics. Nature can inspire novel solutions. Polydopamine, with strong adhesion power of mussel proteins, can open new venues for the facile development of functionalized energetic materials. HMX, one of the most powerful energetic materials in use, was surface modified with PDA. The reactive amine groups of PDA surfactant were employed for noble metal catalyst deposition. Silver nanocatalyst was deposited on HMX surface. Uniform deposition of silver nanocatalyst was assessed using EDAX detector. Decomposition kinetics was investigated via isoconversional (model free) and model fitting. Kissinger, Kissinger–Akahira–Sunose (KAS), integral isoconversional method of Ozawa, Flynn, and Wall (FWO), and differential isoconversional method of Friedman. Silver nanocatalyst offered an increase in HMX decomposition enthalpy by 32.4%. In the meantime, HMX activation energy was decreased from 350 ± 2.53 to 284.9 ± 1.5 kJ mol−1 by Friedman method. Silver nanocatalyst could combust exothermically; it could induce condensed phase reactions that could boost HMX decomposition. Silver nanocatalyst experienced change in HMX decomposition model from diffusion reaction (D1) to (A3) known as three-dimensional random nucleation and growth. Surface modification with PDA secured enhanced HMX sensitivity to falling mass impact by 40%.
Ethics: An Impossible Politics—Perversion, Law and Racial Difference
Authors: Zevnik Andreja 
Published: October 2023

AbstractThis paper takes the removal of the Colston statue in Bristol in the summer of 2020 and the accompanying Black Lives Matter protest as a political setting which can help us explore the radical political potential of Ari Hirvonen’s work. In this intervention I return to some of the themes that his work continuously engages with (such as the question of the limits, transgressions of law, and ethical acts), and re-think them in the context of racial justice. This think-piece opens with reconsideration of ethics and politics drawing on Hirvonen’s brilliant readings of the Antigone and his last book Ethics of Tragedy. By reading transgressions of law as forms of (productive) perversions, this intervention, explores ways in which a different kind of politics might emerge. If in most of his works, Hirvonen saw radical democracy as a vehicle for socio-political transformation, his last work, I argue, moves towards radical even revolutionary transformations. Here I propose to read actions taken by the contemporary racial justice groups as an attempt to embody ‘perversion as rebellion’ or perversion as resistance (both ideas found in Hirvonen’s work).
An Expanded Model for the Pressure Effect in Metal Dusting of Mn-Containing Alloy 600 Based on Advanced Scale Characterization
Authors: Galetz M. C. , Schlereth C. , White E. M. H. , Boll T. , Bik M. , Sitarz M. , Chen W.-T. , Gleeson B. 
Published: October 2023

AbstractCommercial alloy 600 was exposed to a metal dusting inducing gas mixture to investigate the effect of ambient and elevated pressures on the oxide scale formation behavior. The formed scales on this alloy were investigated via Raman spectroscopy, transmission electron microscopy (TEM), and atom probe tomography (APT) to reveal the differences in their morphology and chemical composition(s). Raman spectroscopy revealed graphite within the chromia scales as well as oxide grains with Mn–Cr spinel. High-pressure exposure promoted the presence of Mn within the oxide scale, and APT demonstrated these Mn-enriched areas dissolved up to 4 at.% C. This was consistent with the TEM results, which confirmed higher amounts of Mn in the scale formed under elevated pressure, as well as crystalline graphite in the scales for both conditions. The consequences for the scale breakdown, reflecting the end of the incubation time for metal dusting attack, are discussed in light of these results. A two-fragment dissociative adsorption model for CO, previously applied to catalysis reactions, is proposed when Mn is incorporated into the chromia scale.
Enhancing Impact: A Call to Action for Equitable Implementation Science
Authors: Shelton Rachel C. , Brownson Ross C. 
Published: October 2023

AbstractDespite investments in evidence-based interventions and Implementation Science, most evidence-based interventions are not widely or routinely adopted, delivered, or sustained in many real-world community and healthcare settings. This gap is even greater in settings and populations experiencing numerous social and structural barriers to health, with important implications for persistent patterns in health inequities. In this Viewpoint, as part of a Special Issue on Advancing the Adaptability of Chronic Disease Prevention and Management through Implementation Science, we outline seven calls to action for the field of Implementation Science, with the goal of encouraging researchers, practitioners, and funders to be more intentional and accountable in applying Implementation Science to have greater impact on promoting health equity. Calls to action include (1) enhance public health, community, and multi-sectoral partnerships to promote health equity and equitable implementation; (2) revisit and build the evidence base needed to promote health equity and impact at multiple levels; (3) prioritize focus on policy development, dissemination, and implementation; (4) be agile and responsive in application of Implementation Science frameworks, processes, and methods; (5) identify and redefine meaningful metrics for equity and impact; (6) disseminate scientific evidence and research to a diverse range of partners and potential beneficiaries; and (7) extend focus on de-implementation, mis-implementation, and sustainability which are central to enhancing health equity. Additionally, we outline why a focus on prevention and public health is essential to making progress towards health equity in Implementation Science, summarize important advancements that the field has made towards making equity more foundational, and pose important research questions to enhance equitable impact of work in this area.
Child–Adult Contract for Prevention of Tobacco Use: “As-Treated” Analysis of a Cluster Randomized Controlled Trial (the TOPAS Study) at 3-Year Follow-Up
Authors: Beeres Dorien Tecla , Pulkki-Brännström Anni-Maria , Nilsson Maria , Galanti Maria Rosaria 
Published: October 2023

AbstractTo estimate the effect of a 3-year commitment to remain tobacco free on tobacco uptake among high school students in Sweden. The commitment is developed in the form of a contract between a child and a significant adult, constituting the core component of Tobacco-free Duo (T-Duo), a Swedish school-based tobacco prevention program. Secondary analysis of data from a cluster randomized controlled trial. Participants were 586 students in high schools assigned to the intervention arm of T-Duo. At inception, participants attended grade 7 (i.e., age 12–13). Only students who were tobacco naïve at baseline for the respective outcome and participated in all follow-ups were included. The exposure was defined as signing a 3-year contract with a significant adult, categorized as “stable contract” (3 years contract with the same contract partner), “unstable” (signed a contract sometime during follow-up but this was not sustained over time and/or with the same partner), and “no contract” at all during the intervention period. The primary outcome was having never tried cigarette smoking at the end of grade 9. Exposure and outcomes were self-reported in yearly questionnaires. Of 586 students, 321 (55%) held a stable contract, 204 (35%) an unstable contract, and 61 (10%) did not sign a contract at all. At the end of grade 9 (age 15–16), the relative risk (RR) to remain cigarette free was 1.11 (95% CI 1.00–1.22) (Number Needed to Treat = 10) among students in any type of contract compared to students that did not write a contract at all. The RRs for remaining tobacco free (secondary outcomes) ranged from 1.07 (0.98–1.16) for regular snus use to 1.16 (1.00–1.35) for any type of tobacco use. A commitment to remain tobacco free through a child–adult contract seems to exert a preventive effect on the uptake of tobacco use among Swedish adolescents over 3 school years. The current findings apply to a selected sample of both schools and students. Registration: Current Controlled Trials ISRCTN52858080 Date: January 4, 2019, retrospectively registered.