bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparación clínica en el manejo remoto del asma bronquial durante la pandemia COVID-19 entre dos terapias controladoras: fluticasona y beclometasona
Authors: Recabarren Lozada Arturo Felipe , Llanos Rosas Marcos Gustavo , Llave Pinto Gustavo Joel 
Published: February 2024

Objetivo: Comparar el nivel de control del asma mediante el uso del Asthma Control Test (ACT) y manifestaciones clínicas en dos grupos de pacientes tratados con diferentes corticosteroides inhalados (GCI).
Materiales y métodos. Estudio descriptivo, observacional y prospectivo donde se registró en 521 niños del programa de asma del Hospital III Yanahuara (Arequipa, Perú) el Nivel de Control del Asma, durante el periodo de junio del 2020 a diciembre 2021, por medio de la consulta remota empleando el ACT y la recopilación de los hallazgos clínicos (síntomas diurnos, nocturnos, visita a emergencias y uso de broncodilatadores beta 2 agonistas), en dos momentos durante la pandemia COVID-19.
Resultados. Ambos grupos tuvieron un control óptimo al inicio y final del estudio, con una mejoría significativa en el último control (P < 0.05). En las manifestaciones clínicas no hubo una diferencia estadística (P > 0.05) en ambos controles. El nivel promedio del ACT de la Fluticasona al egreso, tuvo una superioridad significativa frente a la Beclometasona (P = 0.03).
Conclusiones. La Teleconsulta es una herramienta eficaz para el monitoreo de enfermedades crónicas como lo es el asma. Tanto Fluticasona cómo Beclometasona lograron un control óptimo de la enfermedad, destacando que el verdadero factor determinante para lograr un buen control es el uso continuo de cualquier GCI. Sin embargo, se encontró una diferencia estadística significativa a favor de la Fluticasona; no obstante, por su menor precio, la relación costo-eficacia favorece a Beclometasona como opción económica y eficiente para un óptimo control del asma.
SERIAL CASES INTRAVITREAL TENECTEPLASE AND PNEUMATIC DISPLACEMENT OF SUBMACULAR HEMORRHAGE
Authors: Dewi Upik Mahna 
Published: February 2024

Introduction : OBJECTIVE Submacular hemorrhage {SMH} is uncommon complication of choroidal or retinal vascular abnormalities, including choroidal neovascularization {CNV}, polypoidal choroidal vasculopathy {PCV} and retinal macroaneurysm of these, PCV is condition most frequency associated with large SMH {reported in 20%-63% of eyes with PCV} PURPOSE To presence successful management of submacular hemorrhage with combination injection intravitreal {IVT} Tenecteplase and gas C3F8 100%
Case Illustration : METHODES All patient with SMH already take foto fundus and OCT pre and post IVT methalyse and gas C3F8 100%. All patients undergone IVT gas C3F8 100% 0.2 cc and take a rest for 20 second after that IVT methalyse 0.1 cc was injected. Positioning 1st 24 hours: Free Positioning, 2nd 24 hour: Positioned face down, 3rd days: Follow up.
Discussion : RESULT The submacular hemorrhage move out from macular for all of cases. Vision improvement occourred in all cases.
Conclusion : CONCLUTION Intravitreal Tenecteplase in conjunction with pneumatic displacement appears effective in displacing submacular blood.
CHARACTERISTICS OF RETINOPATHY OF PREMATURITY IN MAKASSAR BETWEEN JANUARY 2020 AND DECEMBER 2022
Authors: RAHMAH MARLYANTI NUR , MUHIDDIN HABIBAH S. 
Published: February 2024

Introduction & Objectives : Introduction: Retinopathy of Prematurity (ROP) is one of the leading causes of irreversible visual impairment in infants, especially in premature infants. Preterm birth leads to incomplete development of retina that will cause ROP. ROP screening is an early strategy to prevent irreversible blindness in ROP. Objective: The purpose of this study was to describe the characteristics of ROP in Makassar between January 2020 and December 2022.
Methods : A multi-center observational descriptive study at ten hospitals in Makassar.
Results : The total patients in this study were 168 infants (336 eyes) included 53.25% male and 46.15% female. The incidence of ROP in Makassar between January 2020 and December 2022 was 14.87%. Most of the patients had history of preterm birth with gestational age ranged from 28 to 33 weeks and low birth weight less than 1500 gram in 50% patients. Majority of patients had history of oxygen therapy (77.98%), and other risk factors such as sepsis, twin birth, history of transfusion, or apnea. About 98.81% patients had bilateral ROP and 33.93% were diagnosed with stage 3 at first screening. Photocoagulation laser was done in 41 patients (24.40%).
Conclusion : The ROP screening in Makassar had a good outcome in managing the premature infants, so they can be diagnosed and got treated earlier. A sustainable screening program is required to prevent the irreversible blindness due to ROP.
Neutrophil-Lymphocyte Ratio as an Inflammatory Marker for Retrobulbar Optic Neuritis
Authors: I Gusti Agung Made SIddhi Putra  , Indra Yti Mahayana  
Published: February 2024

Abstract
Introduction & Objectives : Retrobulbar optic neuritis is a form of optic neuritis which part at the back of the eye become inflamed and demyelinated. The inflammatory response might be important for diagnosis and prognosis because in retrobulbar optic neuritis, everything seems normal anteriorly. This study aims to analyze the parameter changes of CBC in retrobulbar optic neuritis.
Methods : Patients with retrobulbar optic neuritis who were admitted to the Yogyakarta Tertiary Hospital from January 2020 to March 2022 were included in this study. Age-matched healthy patients were recruited for comparison (controls). A venous blood sample was obtained as part of the examination at the first visit. The primary measure was white blood cells (WBC), while the secondary measures were neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), haemoglobin, platelets, neutrophils, and lymphocytes counts.
Results : 20 Patients were enrolled in case group, with mean age 27.75(±10.9)Y.O. and 13(65%) of them were female. overall, 4(20%) patients had bilateral involvement. Erythrocytes(p=0.45), Haemoglobin(p=0.17), Haematocrit(p=0.126), Thrombocyte(p=0.86), Monocyte(p=0.68), LMR(p=0.26), PLR(p=0.074) were insignificantly different between both group. Meanwhile Neutrophil(p=0.006) and NLR(p=0.021) were significantly higher in case group also Lymphocyte(p=0.05), Eosinophil(p=0.004)and Basophil(p=0.016) were significantly lower in case group.
Conclusion : The inflammatory Parameters such as Neutrophil and NLR were found to be significantly higher in retrobulbar optic neuritis patients although other parameters like WBC were insignificantly different, even some parameters like Lymphocyte were significantly lower in retrobulbar optic neuritis. thus, these parameters especially NLR might be attributable to the pathogenesis of retrobulbar optic neuritis even when the WBC seems in normal limit.
Success Rate of Glaucoma Drainage Device Implantation in Kariadi General Hospital Semarang 2020-2022
Authors: Apriliana Rina , Rachmi Fifin L , Puspasari Denti , Maharani  
Published: February 2024

Introduction & ObjectivesGlaucoma is a leading cause of irreversible blindness, and implantation of drainage devices is aneffective treatment option for patients with advanced glaucoma. The purpose of this study was toinvestigate success rate of glaucoma drainage devices implantation in Kariadi Hospital
MethodsThis study was an observational analytic study with a retrospective design. All patients who receivedVirna implantation between January 2020 and December 2022 were included. Intraocular pressure(IOP) examination was performed at baseline and at the first day, seventh day, first month, and thirdmonth following surgery. The success rate was divided into three groups: complete success if IOPwas <21mmHg without medication, qualified success if IOP was <21mmHg with medication, andfailure if IOP was >21mmHg with medication.
ResultsThis study included 42 patients (42 eyes) with an average age of 43.3 years. There were 16 male(38%) and 26 female (62%) patients in the group. Of these patients, 11 (26.2%) had primaryglaucoma and 31 (73.8%) had secondary glaucoma. There was significant decrease in IOP frompreoperative measurement (37.1±10.1mmHg) compared to IOP on first day (13.0±6.0mmHg),seventh day (15.4±3.8mmHg), first month (18.2±4.4mmHg), and third month (23.4±8.9mmHg) aftersurgery (p<0.05). At three-month follow-up, complete success was 14.29%, qualified success was50%, and failure was 35.71%.
ConclusionGlaucoma drainage device implantation was found to successfully reduce IOP in patients withadvanced glaucoma. The qualified success rate was higher than complete success rate, suggestingthat some patients may require medication to achieve target IOP levels.
THE EXPRESSION OF ALPHA-SMOOTH MUSCLE ACTIN IN CONTRACTED SOCKET
Authors: Theresia Dwiamelia  
Published: February 2024

Abstract
Introduction & Objectives : A contracted socket is considered a common complication in anophthalmic patients, with the resulting poor fitting of an ocular prosthesis. In severe cases where patients have had multiple previous reconstructive attempts, further socket contraction may result from fibrosis, leading to eventual surgical failure. Alpha-smooth muscle actin (alpha-SMA) is often used to identify pathologic fibroblasts. It may serve as a reliable marker for myofibroblast cells. The aim of the study was to find alpha-SMA protein expression in myofibroblasts derived from orbital socket contracture.
Methods : In this study, we observed five patients with contracted sockets who underwent fornicoplasty and buccal graft surgery from October 2022 to February 2023. Tissue samples were taken from the conjunctival fornix area during the surgery and then examined for alpha-SMA expression.
Results : In this study, there were 2 out of 5 (40%) positive alpha-SMA expressions with history of recurrent contraction, 2 (40%) negative expressions with no history of recurrent contraction, and 1 result that could not be assessed due to the limited number of samples containing fibroblasts in patient with history of recurrent contraction.
Conclusion : Alpha-SMA levels can be detected in patients with contracted sockets. Patients with a history of recurrently contracted sockets have a tendency to express positive alpha-SMA. This may allow for the need for the administration of antimetabolites in patients with recurrent contracted sockets to avoid recurrence of this contracted socket.
Binocular Diplopia in Miller Fisher Syndrome Pediatric Patient: A Rare Case Report
Authors: Zhafira Dinda , Prastyani Reni , Gunawan Prastiya Indra , Noviandi Riza , Samosir Sunny Mariana 
Published: February 2024

Introduction : Miller Fisher Syndrome (MFS) is a rare variant of Guillain-Barré syndrome that usually presents with ataxia, areflexia and ophthalmoplegia. It is more common among patients in their 40s and number of cases in pediatric patients is significantly smaller. Our objective is to report a rare case of diplopia in Miller Fisher.
Case Illustration : An 11 years old boy came with complaint of double vision and history of gaze restriction. Patient had history of inpatient admission due to acute progressive generalized limb weakness and walking difficulty followed by respiratory failure. Patient also had history of chewing and swallowing difficulty. Inpatient treatment included intravenous immunoglobulin (IVIG) for 5 days which resultedin clinical improvement. Electromyography examination done while hospitalization showed normal results. Orthoptic examination revealed 15 degrees exotropia of left eye with 30 prism dioptres (PD) at near and far distance. Worth four dot test resulted in cross diplopia with no abnormality in head CT scan. After 2 months follow-up with push-up pencil exercise, patient showed improvement of symptoms.
Discussion : MFS is a clinical diagnosis that can be assessed by clinical triad of ataxia, areflexia and ophthalmoplegia. Diagnosis can be supported by ancillary test such as cerebrospinal fluid analysis, electrophysiologic studies or antibody anti-GQ1b . Treatment of MFS are mainly for supportive care with respiratory support and immunotherapy if needed in severe cases.
Conclusion : The outcome of MFS is usually good with a complete recovery. The improvements generally begin within two to four weeks after the onset of neurological symptoms and complete within six months.
Severe Case Of Delayed Diagnosed Of >10 Years Untreated Newborn Congenital Glaucoma
Authors: Yudakusuma Cheryll , Siahaan Yoseph M.P. A 
Published: February 2024

Introduction : Though cases of newborn primary congenital glaucoma (PCG) had poor prognosis, we couldn’t simply ignore that early proper diagnostic and treatment can still improves quality of one’s sight, which’s absent in this case. Presented with delayed diagnosed highly suspected case of newborn PCG, physician was compelled to make the best in condition of the already given poor prognosis to begin with.
Case Illustration : A 13 years old female patient came to eye clinic with a very disturbing chronic condition of visual loss. Accompanied by her family, who also claimed had witnessed both the patient’s eyes appeared whitish since birth. Eye examination revealed visual acuity of 1/~ for right eye and no light perception for left eye, along with significant signs of buphthalmos, epiphora, nystagmus, megalocornea (diameter of 9x14mm right eye and 9x13.3mm left eye), cloudy cornea, leukocoria, and Schiotz tonometry of 60-100mmHg in both eyes. Patient then received oral Acetazolamide, Levofloxacin eye drop, and Timolol Maleate 0,5% eye drop; then advised to return for one week evaluation also to bring her siblings to be subjected to glaucoma screening.
Discussion : The decision to perform surgical intervention in cases of newborn PCG commonly require further thoughts. This case immediately shifted our focus towards palliative care of the patient whilst continuing monitoring IOP, as glaucoma surgery possessed a more menacing risk to be performed this patient.
Conclusion : All cases of pediatric glaucoma require a life time of comprehensive management that requires heedfulness especially from caregivers as it is a very challenging disease.
Visual Improvement Following Glaucoma Surgery
Authors: Purnamasari Heronita 
Published: February 2024

Introduction : Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness. The aim of glaucoma treatment is to slow progression and minimize the risk of further damage, not to expect functional improvement. We report the case of a patient who experienced an improvement in vision following glaucoma surgery and review the literature regarding this phenomenon.
Case Illustration : A 66-year old female presented with vision loss in the left eye that could only perceive finger counting in one meter. Her intraocular pressure (IOP) measured 51,8 mmHg and she was found to have primary open angle glaucoma. Medical treatment was commenced and she underwent a successful trabeculectomy. Unexpectedly she experienced improvement in vision after treatment. At her recent visit visual acuity was 6/30 in the affected eye.
Discussion : Although the mechanism of improved vision cannot be proven it is likely that successful lowering of IOP resulted in some reversal of retinal ganglion cell dysfunction. Some evidence explained that retinal ganglion cells damaged by glaucoma might undergo a period of reversible dysfunction preceding cell death. Furthermore, reversible changes in optic nerve head morphology have been reported following reduction of intraocular pressure. These observations suggest that certain structural and functional improvements may in fact be possible in some patients. The changes of anterior chamber depth, corneal radius of curvature, corneal thickness or corneal edema could be considered as other factors which influence this improvement.
Conclusion : Functional improvements may occur following trabeculectomy. Glaucoma surgery should be offered early, and considered even in those with reduced visual acuity.
Characteristics of Patients with Eyelid Laceration in Kariadi General Hospital Semarang
Authors: ADERIESTA PADMASTRIMAYA  , RAJA ERINDA  
Published: February 2024

Abstract
Introduction & Objectives : Eyelid laceration is one of the most common ocular injuries with complications. This study examines patient characteristics with eyelid lacerations at Kariadi General Hospital Semarang.
Methods : An observational study used medical records data from April 2019 to January 2023. Age, gender, eyelids, grading, area of laceration, mechanism of trauma and injury, canthal and canalicular involvement, associated injury, and surgery were recorded.
Results : From 75 patients, lacerations were more common in men (56, 75%) and ages 16-<50 years (43, 57%). Lacerations occurred in right lower (21, 28%), right upper (17, 23%), right upper and lower (16, 21%), left lower (9, 12%), left upper (8, 11%), and left upper and lower (4, 5%) eyelids. They were mainly medial (52, 69%), lateral (12, 16%), and central (7, 9%). Full-thickness lacerations (58, 77%) outnumbered lamellar thickness (17, 23%). Blunt trauma (63, 84%) was the main mechanism, with motor vehicle accidents leading 30 (40%). Canthal involvement was absent in 41 cases (55%), medial in 29 (39%), and lateral in 5 (7%). Canalicular involvement was absent in 39 cases (52%) and present in 36 (48%). The three most frequent of associated injury of the patients was 16 (21%) subconjunctival bleeding, 12 (16%) orbital hematom, 9 (12%) conjunctival laceration. All patients underwent surgery, with eyelid repair most common (32, 43%).
Conclusion : Eyelid lacerations mainly involved right lower eyelid, medial region, and are full-thickness. Blunt trauma, particularly motor vehicle accidents, was the main cause. Most cases lack canthal or canalicular involvement. Eyelid repair was the most frequent choice of surgery.
PUPIL CYCLE TIME AND PERIPAPILLARY PERFUSION IN ANGLE CLOSURE GLAUCOMA
Authors: Kamal Muhammad Alfin , Rahmi Fifin Luthfia , Puspasari Denti , Cahyono Maharani 
Published: February 2024

Introduction & ObjectivesOne of important roles in the pathogenesis of glaucoma is vascular condition. To enhance glaucomamanagement, the clinical assessment of ocular perfusion is required. The pupillary light reflex'safferent or efferent pathways may become impaired as a result of pupil cycle time (PCT) elongation.PCT is a simple objective method to measure the function of optic nerve, including glaucoma. Thepurpose of this study is to evaluate the connection between pupil PCT and peripapillary perfusion.
MethodsA cross-sectional study from Kariadi Hospital included 26 eyes with angle closure glaucoma and 26eyes of healthy patients. Complete ophthalmologic examinations, PCT measurements, and OCTperipapillary angiography were performed on each patient. Patients with history of drugs use thatcan affect pupillary reflexes such as barbiturates, methyldopa, anaesthetics, and antidepressant, andpatients with history of glaucoma attack are excluded. The comparisons between the two groupswere examined, with a p<0.05 indicating statistical significance.
ResultsThe mean PCT of normal subjects was 943,4ms (882,4ms – 993,4ms) and angle closure glaucomasubject was 1789,5ms (1060ms – 4600ms). There were statistically significant difference of PCTvalue in angle closure glaucoma compared to normal subjects (P<0,05). Peripapillary flow index andperipapillary vessel density in closed angle glaucomatous eyes were lower than normal eyes(P<0.05). There is a significant relationship between PCT with peripapillary flow index andperipapillary vessel density. (P<0,05).
ConclusionIn angle closure glaucoma, prolonged PCT associated with decreased peripapillary perfusion asshown by decreases in peripapillary flow index and peripapillary vascular density.
CONSISTENCY OF TBUT VS NIBUT MEASUREMENT FOR ASSESSMENT OF DRY EYE DISEASE IN COMPUTER VISION SYNDROME
Authors: ANGELINA SURYA TALLO  
Published: February 2024

Abstract
Introduction & Objectives : The coronavirus disease (COVID-19) pandemic requires medical faculty students to attend distance lectures using computers for long periods of time which directly has an impact of computer vision syndrome (CVS) which can progress to dry eye disease (DED). One of the tear film stability tests is the Tear Break Up Time, both with the invasive tear break up time (TBUT) technique and the non- invasive tear break up time (NIBUT) technique. This study aims to determine the consistency of tear film stability measurements using these two techniques in medical faculty students who suffer from CVS with and without DED.
Methods : 62 medical students of Udayana University were enrolled in this study and devided into two groups namely CVS with DED symptoms and CVS without DED symptoms. Both groups were underwent TBUT examination using fluorescein strips and cobalt blue filter with slitlamp biomicroscopic and NIBUT examination with the tear film analysis software from Medmont E300 corneal topography.
Results : There was no significant difference between TBUT and NIBUT measurements in the DED group (p=0.1985) and in the Non-DED group (p=0.9336). There was no difference in the consistency of TBUT and NIBUT in the two groups (p=0.4550).
Conclusion : Both techniques provide consistent results in assessing DED. NIBUT technique is faster and more convenient for patients also can be an alternative for practitioners to diagnose DED if it is not possible to use TBUT due to allergies or the unavailability of fluorescein at the clinic.
EFFECT OF LOW-DENSITY LIPOPROTEIN (LDL) CHOLESTEROL VALUE ON NON-PROLIFERATIVE DIABETIC RETINOPATHY (NPDR) IN PATIENTS WITH TYPE II DIABETES MELLITUS (T2DM): A SYSTEMATIC REVIEW
Authors: Nugraha Satria Budi , Siahaan Sp. M Dr. Yoseph M.P.A. 
Published: February 2024

Introduction & Objectives : Type 2 Diabetes Mellitus (T2DM) is a metabolic disease in which the body is unable to control blood sugar levels and is characterized by hyperglycemia caused by lack of insulin action. One of the most common microvascular complications of DM that can cause blindness to sufferers is Diabetic Retinopathy (DR). One of the risk factors that can exacerbate the progression of T2DM is the level of Low-Density Lipoprotein (LDL). However, there are still differences of opinion in several studies if LDL has a significant role in the occurrence of DR. This study aimed to determine whether there is a relationship between the value of LDL cholesterol and the occurrence of Non-Proliferative Diabetic Retinopathy.
Methods : Systematic review utilizing MeSH terminology and PICO methods were done for information extraction of online database, including PubMed, and Google Scholar by utilizing the following keyword “Low-Density Lipoprotein”, “Non-Proliferative Diabetic Retinopathy”, “Diabetes Melitus”. The extracted studies were then analyzed using the New-Castle Ottawa Scale (NOS).
Results : In total, 2 eligible studies (103 subjects) were found. Dornan et al., stated that total cholesterol levels were higher in NPDR Patients (5.1 +/- 0.7 mmol/l, p ? 0,02) and Mursi et al., shows that in patients with uncontrolled LDL cholesterol, NPDR was found (53,7%, p < 0,015). NOS was used to evaluate the quality of the studies and all studies showed to be in good quality.
Conclusion : According to the results of this systematic review, there is a significant correlation between the degree of diabetic retinopathy and LDL cholesterol.