bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dupilumab as a Combination Therapy to Oral Systemic Immunomodulators for Moderate-to-Severe Atopic Dermatitis for Skin of Color Children in Resource-Limited Setting: A Case Series
Authors: Nuraihan Siti , Azmi MN , Begum Sabeera , Leong Kin Fon 
Published: October 2023

Abstract
Subcutaneous dupilumab, with or without topical therapy, is clinically proven to treat children with moderate-to-severe atopic dermatitis (AD). However, this well-researched biologic for AD in children is still among the most expensive medication in the world and not widely available in resource-poor areas. We share our experience managing four children with severe AD, aged 3 to 11, who poorly responded to oral systemic immunomodulators but successfully achieved rapid clinical remission when combined with subcutaneous dupilumab. No loading doses were administered to patients in this case series, and the maintenance dosages used were lower than the manufacturer’s recommendations. This case series illustrates that oral immunomodulators in combination with subcutaneous dupilumab therapy are efficacious, safe, tolerable, and cost-effective for children with moderate-to-severe AD. This treatment strategy can be considered an alternative for children with AD recalcitrant to other available treatment options, especially when AD management is challenging in limited resource settings.
Hepatitis B Immunity Status among Healthcare Sciences Students, 20 Years after the Infantile Vaccination: The Most Appropriate Policy to Confer Full Protection.
Authors: Saffar Mohammad-Jaafar , Hiva  , Saffar Hana , Mousavi Sayed Jaber , Shiraj Hanieh , Rezaei Mohammed-Sadegh. 
Published: October 2023

Abstract
Background. During recent years, an increasing number of previously vaccinated children against hepatitis B (HBV) may begin activities as healthcare sciences students (HSS), so, at the higher risk of HBV infection. Therefore, documenting their immunity at before training was recommended. To evaluate their immunity status, as well as measuring the presence of immunological memory and protection through administering 1-to-3 additional doses of HBV vaccine among HSS who have been immunized at childhood, this study was conducted.
Subjects and Methods. The vaccination status of the accepted HSS was documented by reviewing their vaccination record card. HBV infection markers at before, and following 1-to3 dose of HBV vaccine were measured using ELISA. Simple descriptive statistical methods were used to analyze collected data.
Results. Totally, 274 HSS, 59.1% female, with mean age 23.8 years were included. Of those, 228 in infancy, and 46 within last 12-years have been immunized. From 228 infantile immunized students,103 with 1-to-3 doses of HBV vaccine were vaccinated. Of 125 non-boosted HSS, 64 preserved their protective antibody titers. The proportion of protected students and their antibody levels were increased significantly and approached to 96.8% following 3-doses of booster injection.
Conclusion. Nearly half of the vaccinated students had lost their protective antibody titers, but, the majority of them preserved their immunological memory, detected through anamnestic response to booster vaccination. To provide appropriate protection, universal vaccination with one-doses of HBV vaccine followed by serological monitoring to identify non-protected students for further management seems reasonable.
Cáncer colorectal en el embarazo. Reportes de caso
Authors: Haro Sánchez Silvia Ivonne , Jave Cardich Samy Liz 
Published: October 2023

El cáncer colorrectal (CCR) durante el embarazo es una neoplasia poco frecuente, con una incidencia entre el 0,07- 0,1% en la población. Para un diagnóstico preciso es necesaria una alta sospecha y con ello realizar pruebas diagnósticas oportunas. Cuando no se tiene sospecha ni se busca el diagnóstico, el pronóstico suele ser malo, ya que muchas veces se halla en estado avanzado. Presentamos los casos de dos gestantes de 27 y 31 años, diagnosticadas de adenocarcinoma colorrectales medianamente diferenciados a las 29 y 30 semanas de gestación, respectivamente. Debido a la importancia de realizar un diagnóstico oportuno para mejorar la sobrevida de las pacientes, se realizó una búsqueda de información en la literatura en relación con el diagnóstico, manejo y pronóstico de esta patología.
Bureaucracy, Situation, Discrimination, and Elite in Islamic Education Perspective of Digital Era
Authors: Badruzaman Abad , Hosaini Hosaini , Halim Abdul 
Published: October 2023

The article is to find out the definition and system of good and correct bureaucracy from an Islamic education perspective in the Digital Era. To find out the definition and practice of discrimination as well as solutions to deal with discrimination from an Islamic education perspective. To find out the definition of elite in the Islamic view of the digital era. The researchers engage in synthesizing the gathered information and conducting a thorough analysis. It presents this literature review within a descriptive qualitative research framework, adopting a phenomenological approach, to extract insights that address the research question by first collecting data and then seeking understanding. The result show that Discrimination can be overcome by instilling the teachings of the Islamic religion (caliphate principles) into oneself by accepting the nature of humans as social creatures who must live side by side with other humans who have different personalities and characteristics. At the elite level of thinking, we observe a pragmatic approach as elites gravitate toward populist figures to boost their popularity. This behavior is often characterized as a form of currying favor with those in power. The resulting phenomenon has generated narratives that have become a source of political turmoil, leading to widespread unrest among the grassroots population.
Keywords: Elite in Digital Era, Discrimination in Digital Era, Bureaucracy in Digital Era
O USO DO INFLIXIMABE NO TRATAMENTO DA DOENÇA DE CROHN: UMA REVISÃO DA LITERATURA
Authors: Santos Débora Nogueira , Aquino Liliane Portilho de , Botelho Mayara Larissa da Costa , Virgolino Heloísa Batista , Nobre Luiz Henrique Coelho , Quemel Gleicy Kelly China 
Published: October 2023

A doença de Crohn (DC) é uma doença crônica inflamatória que atinge, predominantemente, a parte inferior do intestino delgado (íleo) e intestino grosso (cólon), mas pode afetar qualquer parte do trato gastrointestinal. O tratamento farmacológico pode ser realizado com medicamentos imunobiológicos, como o infliximabe. Assim o trabalho objetivou revisar a eficácia da terapia farmacológia usando o infliximabe no tratamento da doença de crohn. Foi realizada uma revisão integrativa da literatura (RIL) com o auxílio da análise de conteúdo proposta por Bardin. A pergunta norteadora do trabalho foi: “Qual a eficácia do infliximabe no tratamento da DC”. A busca das literaturas foram nas bases de dados MEDLINE, LILACS e SCIELO, e os critérios utilizados para a seleção das literaturas foram: estudos completos nos idiomas inglês e português, publicados no período de 2012 a 2022; e exclusas literaturas pagas e duplicadas. Após as buscas foram selecionados estudos, em que 80% (8) no idioma inglês e 20% (2) em português, sendo 50%(5) MEDLINE, 30%(3) na LILACS e 20% (2) no SCIELO. Com base nos estudos selecionados foi possível observar que a maioria dos autores ratifica a eficácia do infliximabe como tratamento para DC, principalmente níveis moderado à grave da doença, pois impede que o fator de necrose tumoral se ligue com seus receptores e neutraliza a atividade biológica do TNF-α, induzindo a remissão da referida doença.
Volcanism straddling the Miocene–Pliocene boundary on Patmos and Chiliomodi islands (southeastern Aegean Sea): insights from new 40Ar ∕ 39Ar ages
Authors: Boehm Katharina M. , Kuiper Klaudia F. , Uzel Bora , Vroon Pieter Z. , Wijbrans Jan R. 
Published: October 2023

Abstract. The island of Patmos, in the eastern Aegean Sea, consists
almost entirely of late Miocene to Pliocene volcanic rocks. The magmatism in
the Aegean is governed by subduction of the African plate below the Eurasian
plate, back-arc extension, slab rollback, slab edge processes and westward
extrusion of central Anatolia to the west along the Northern Anatolian Fault
into the Aegean domain. The evolution of the Aegean basin is that of a
back-arc setting, with a southerly trend in the locus of both convergent
tectonics and back-arc stretching, allowing intermittent upwelling of arc,
lithospheric and asthenospheric magmas. Here, we present new 40Ar/39Ar age data for Patmos and the nearby
small island of Chiliomodi to place this volcanism in a new high-resolution
geochronological framework. High-resolution geochronology provides a key to
understanding the mechanisms of both the tectonic and magmatic processes
that cause the extrusion of magma locally and sheds light on the tectonic
evolution of the larger region of the back-arc basin as a whole. The volcanic series on Patmos is alkalic, consistent with a back-arc
extensional setting, and ranges from trachybasalt to phonolites, trachytes
and rhyolites, with SiO2 ranging from 51.6 wt % to 80.5 wt %, K2O ranging
from 2 wt % to 11.8 wt % and extrusion ages ranging from 6.59 ± 0.04 (0.14) Ma to 5.17 ± 0.02 (0.11) Ma. Volcanism on Patmos and adjacent
Chiliomodi can be understood as a combination of mantle and crustal tectonic
processes including the influence of transform faults and rotational crustal
forces that also caused the widening of the southern Aegean basin due to two
opposite rotational poles in the east and west and rollback of the
subducting slab south of Crete.
VACCINATION STATUS AGAINST HEPATITIS B VIRUS AMONG YOUNG DOCTORS WORKING AT A PUBLIC SECTOR TEACHING HOSPITAL IN PESHAWAR
Authors: Imran Ullah  , Haider Iqbal , Hameed Haidar Khan  , Muhammad Ishaq  , Sahal Arshad  , Muhammad Fayyaz  
Published: October 2023

Objectives: To determine the vaccination status and to find out reasons why young doctors working in KTH do not opt for vaccination against HBV.
Material and Methods: This cross-sectional study was undertaken at Khyber teaching hospital, Peshawar, for four months. A self-administered questionnaire validated by Lynn Criteria and pilot testing for construct, face, and content validity was distributed among young doctors to obtain the vaccination rate and demographic data.
Results: Of the total 150 doctors, who participated in the study, 68.5% were vaccinated. Among them, 38.9% were fully vaccinated with three doses, while the rest were partially vaccinated. The barrier to completing Vaccination in our study population was work overload, negligence, and non-availability of the vaccine.
Conclusion: We observed a low rate of HBV vaccination among young doctors working at Khyber teaching hospital compared to our target vaccination rate. The major frame factors to complete Vaccination in our study population were work overload, negligence, and non-availability of vaccines. Different steps should be taken to ensure the Vaccination of all healthcare workers, including young doctors.
Keywords: Hepatitis B Virus, Vaccination, Healthcare professionals.
COMPARISON OF BLOOD PRESSURE AND HEART RATE AMONG ACTIVE AND PASSIVE CIGARETTE SMOKERS
Authors: Qaiser Ayesha , Shaid Fazlina , Salman Henna , Hamid Naila , Umar Ayub Jibran 
Published: October 2023

OBJECTIVE:To compare the effects of passive and active cigarette smokers on blood pressure and heart rate.
METHODS: It was a cross sectional study based in Physiology department of Khyber Medical College, Peshawar. It was conducted from January 2022 to June 2022. Using non probability convenient sampling, MBBS students and college employees were divided into three groups. Each group had a sample size of 50. Group 1 comprised of passive smokers, group 2 consisted of active smokers and group 3 of nonsmokers. Heart rate and blood pressure, including Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Pulse Pressure, were measured. Data was analysed using SPSS 26.
RESULTS: In Group-1, all smokers were males. In Group-2 (nonsmokers), 42 were males (32.6%) and 8 (34.8%) were females and in Group-3 (passive smokers), 37 were males (28.7%) and 15 were females (65.2%). Using Anova test, the difference in the mean values of systolic blood pressure (SBP) among the three groups was found to be highly significant (0.001), while that of diastolic blood pressure (DBP) non-significant (0.291). The mean values of Heart Rate (HR) among the three groups was also significant (0.049).
CONCLUSION:Smoking effects blood pressure and heart rate, as the systolic blood pressure and heart rate of smokers in our study was raised.
KEY WORDS: Hypertension, smokers, powerlab,
“Abogados de negocios” y la Rule of Law en Brasil
Authors: Engelmann Fabiano 
Published: October 2023

Este artículo tiene como objetivo analizar el espacio del derecho empresarial y su relación con las reformas de las instituciones judiciales en el contexto de la internacionalización del campo jurídico brasileño. Con este propósito, se parte del análisis del espacio académico y de la difusión del ideario de law & economics, el perfil de las grandes sociedades de abogados y de sus principales socios y la expansión de las cámaras de mediación y arbitraje. El material empírico sobre el que se basa este trabajo está constituido principalmente por el análisis cualitativo de documentos y la producción bibliográfica de entrevistas realizadas con juristas y dirigentes políticos. En este sentido, se espera avanzar sobre la hipótesis relativa a la relación entre la circulación internacional de los juristas y los movimientos de exportación-importación de modelos institucionales y su repercusión en la redefinición del espacio jurídico y político brasileño
Las políticas públicas del fomento al crecimiento en Chile. Análisis del primer año del gobierno de Sebastián Piñera
Authors: Agüero Francisco , Rivadeneira Pablo 
Published: October 2023

Este artículo evalúa los resultados de la incorporación del Estatuto PYME en el sistema de análisis regulatorio, que surge como una novedosa iniciativa para aumentar la eficiencia de las políticas publicadas orientadas a las pequeñas y medianas empresas durante el periodo 2010-2011. Los resultados demuestran queexiste un débil marco regulatorio para las empresas de menor tamaño,como consecuencia de la falta de habido apoyo efectivo desde cada uno de losministerios involucrados, con excepción del Ministerio de Economía.
Calidad de la democracia y desempeño institucional en Chile. Un análisis retrospectivo en base a las propuestas del gobierno de Sebastián Piñera
Authors: Avendaño Octavio 
Published: October 2023

El presente trabajo analiza la experiencia más reciente de la democracia chilena, desde los enfoques acerca de la calidad. Para ello, en el análisis se da prioridad a las dimensiones procedimentales, en particular aquellas que combinan participación y competencia política, junto a los procesos de rendición de cuenta (accountability) que se dan desde los órganos especializados del Estado y, sobre todo, desde las instituciones representativas. Se parte del supuesto de que son las dimensiones vinculadas al sistema de representación y de intermediación las que condicionan el éxito y la efectividad que logran alcanzar el resto de las dimensiones procedimentales y sustantivas. Se argumenta que en las propuestas de profundización democrática del actual gobierno existe una serie de vacíos y de omisiones sobre temas sustantivos y de gran relevancia.
El desarrollo de la Ciencia Política en Uruguay
Authors: Buquet Daniel 
Published: October 2023

En el artículo se examina cómo se ha consolidado la Ciencia Política en Uruguay tanto en el espacio académico como en el ámbito profesional. Se señala que el desarrollo de la disciplina es tardío, en relación al mundo y a los países más importantes de América Latina, ya que se inicia posterior a la transición a la democracia del año 1985, no obstante ello ha alcanzado un prestigio creciente. Se argumenta que aun cuando existen aspectos en los cuales es posible acrecentar los indicadores, la Ciencia Política uruguaya cuenta con un plantel de investigadores que ostenta buenos niveles de formación y es productivo en términos generales, tanto en cantidad como en calidad.
De instrumentos militares de la dictadura a instrumentos políticos de la democracia: Regímenes de excepción en Bolivia 2000-2010
Authors: Wright Claire , Soliz Landívar Ana 
Published: October 2023

El objetivo del artículo es descubrir el rol jugado por los regímenes de excepción en la política boliviana contemporánea. A pesar de constituir un legado clave de los regímenes autoritarios y sobrevivientes a las transiciones democráticas en América Latina, los Regímenes de Excepción han sido rara vez estudiados por los cientistas políticos. Centrándonos en el caso de Bolivia, la investigación se basa tanto en las leyes relevantes como en 65 decretos presidenciales, que son analizados mediante el método del análisis de contenido. Como resultado, se demuestra que para Bolivia, tanto el marco legal y el uso político de los Regímenes de Excepción se han transformado desde un mecanismo puramente represivo hacia uno más administrativo. El estudio contiene importantes implicancias sobre cómo los Regímenes de Excepción son conceptualizados desde un punto de vista teórico así como también para el entendimiento de la naturaleza de la política de emergencia de años recientes en democracias frágiles
Aprobación presidencial en Chile 2000-2012: Sus determinantes y su efecto en la toma de decisiones
Authors: Ramírez R. Jorge , Varas V. Pablo 
Published: October 2023

El artículo estudia los determinantes de la aprobación presidencial en Chile mediante análisis cuantitativo de los resultados de la encuesta CEP para el periodo 2000-2012. Por otra parte, se busca contribuir al desarrollo de una línea de investigación sobre el impacto de la aprobación presidencial en la toma de decisiones y la configuración de ciclos políticos. Para ello, se analizan los cambios de gabinete como posible respuesta a la divulgación de lascifras de aprobación presidencial. Entre los principales hallazgos del análisis econométrico se observa que la probabilidad de aprobación presidencial, y su influencia, no son constantes en el tiempo, sino que dependen del presidente de turno. Del mismo modo, no se observa un claro patrón de asociación entre la divulgación de resultados la encuesta CEP y la toma de decisiones estratégicas del ejecutivo, en materia de conformación de gabinetes.
PERIODS OF COLLECTION AND SIZE OF MINI-CUTTINGS IN YERBA - MATE ADVENTITIOUS ROOTING
Authors: Di Carvalho Maria Angelica , Kratz Dagma , Da Luz Angela , De Oliveira Fragoso Rosimeri , Stuepp Carlos André 
Published: October 2023

To improve the production of yerba mate seedlings by increasing rooting rates, clonal propagation is used, especially the mini-cutting technique, which aims to increase genetic gains and production efficiency. Thus, the objective was to evaluate the influence of different sizes of mini-cuttings and successive collections on the rooting and root vigor of Ilex paraguariensis. Four successive collections were carried out and mini-cuttings measuring 4, 6, 8 and 10 cm (± 0.2) in length were made, which were staked in 110 cm 3 tubes and kept in a climate-controlled greenhouse for 45 days. Rooting percentage, number of mini-cutting roots -1 , average length of the three largest mini-cutting roots -1, callus, mortality, survival, and maintenance of original leaves were considered. Rooting was influenced by the size of the mini-cuttings, with mini-cuttings of 8 cm and 10 cm showing greater vigor. The good adaptation of the mini-stumps tends to favor the rooting of the mini-cuttings throughout the collections, showing the potential of the mini-cutting technique for the vegetative influence of Ilex paraguariensis.
Beyond words: A reflection from health professionals around the meaning of ‘hear me, don’t blame me’ in relation to meeting the needs of young people with learning disabilities and autism spectrum conditions
Authors: Griffiths Jack , Harrhy Elizabeth , Wilcox Marielle 
Published: October 2023

This article is a reflective piece written by the Intensive Positive Behaviour Support Service (iPBS) in South Wales. The iPBS team works with children and young people with learning disabilities and/or autism spectrum conditions, that communicate their unmet needs in ways that may challenge and are at risk of their support networks breaking down. The team works within the Positive Behaviour Support Framework and is shaped by attachment and trauma-informed research and practice. The main aims of the service are to understand unmet needs and to improve quality of life.The iPBS team completed a 1-hour reflection considering ‘hear me, don’t blame me’ and what this means to them, their roles and the service as a whole. Three key overarching themes were identified using thematic analysis: service structure, skills, and approach. The team hopes that the themes identified through this exercise will influence future iPBS processes and service delivery. The reflections explored in this article may also be beneficial for parents/carers and professionals working with a united aim of meeting the needs of children and young people presenting with behaviours of concern; beyond words. Clinical implications of the reflective piece are discussed and recommendations for other services to have their own reflections are provided.
CARDIOMIOPATIA DE TAKOTSUBO: DIFERENÇA SOBRE A INCIDÊNCIA ENTRE AS MULHERES NA PÓS-MENOPAUSA E MULHERES FÉRTEIS
Authors: Silva Débora Leny , Santos Marya Anna Clara Souza , Rodrigues Francyelly Alves , Rocha Bruno Pimentel , Oliveira Maria Letícia Cirilo Nobre , Sousa Nathalia Targino , Fermoseli André Fernando de Oliveira , De Oliveira Jaim Simões 
Published: October 2023

A Cardiomiopatia de Takotsubo, ou Síndrome do Coração Partido, é uma rara disfunção ventricular esquerda que atinge o músculo cardíaco, causada principalmente pelo estresse emocional ou físico. A predominância é dada em mulheres no período da pós-menopausa, no entanto, mulheres férteis também podem ser acometidas por essa patologia. Este artigo é uma revisão bibliográfica integrativa e objetiva analisar as diferenças sobre a incidência da cardiomiopatia de Takotsubo em mulheres na pós-menopausa e mulheres férteis. As buscas foram realizadas, até maio de 2022, em duas bases de dados: PubMed e BVS, usando os seguintes descritores: “takotsubo cardiomyopathy”, “postmenopause” e “fertility”. Sendo assim, foram selecionados artigos de diferentes delineamentos experimentais, os quais mostraram os fatores que tornam frequentes a incidência durante a pós-menopausa quando comparada com as mulheres em períodos férteis, uma vez que, apesar de terem estudos limitados acerca do assunto, apresentam alguns fatores de risco associados. Deste modo, é possível concluir que o desequilíbrio hormonal sexual e a presença de transtornos psiquiátricos históricos mostram-se como algumas das condições para a incidência da patologia, respectivamente, em mulheres na pós-menopausa e mulheres férteis, as quais foram abordados ao longo da presente revisão.
Estudios botánicos
Authors: Espinosa Bustos Marcial R. 
Published: October 2023

Sori amphigeni, communiter gregarii in macula isabellina fulvave 1,5-3 cm. longa, 1,5 mm. lata erumpentes, elongati 12-18 mm. longi 0,7-1 mm. lati, recti, in sicco straineis vel subcremeis, pulverulenta, extrema versus sensim acuti marginibus ochraceis elevatis (usque 1 mm.) epidermidis scissae cincti; sporae obovatae, ellipsoidalesve, interdum fere glóbosae, 34-26 µ longae, 20-24 µ latae (in aqua), episporio fere hyalino leniter stramineo, plus miriusfve 1 µ crasso. dense verruculoso.