bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dying 2 Talk: Generating a More Compassion Community for Young People
Authors: Booth Jane , Croucher Karina , Walters Elizabeth , Sutton-Butler Aoife , Booth-Boniface Emmelia , Coe Mia 
Published: November 2023

AbstractPeople in the Global North often have a problem talking about — and processing — the inevitability of death. This can be because death and care of the dying has been professionalised, with encounters of death within our families and communities no longer being ‘normal and routine’ (Kellehear 2005). Young people are particularly excluded from these conversations, with implications for future mental health and wellbeing (Ainsley-Green 2017). Working in Wolverhampton and Bradford, the Dying 2 Talk (D2T) project aimed to build young people’s future resilience around this challenging topic. We recruited over 20 young people as project ambassadors to co-produce resources that would encourage talk about death, dying and bereavement. The resources were used as the basis of ‘Festivals of the Dead’ which were taken to schools to engage wider audiences of young people (aged 11 +). The project aimed to use alternative ‘ways in’ to open discussion, beginning with archaeology, and ultimately using gaming, dance, creative writing and other creative outputs to facilitate discussion, encourage compassionate relationships and build resilience. The resources succeeded in engaging young people from ages 11–19 years, facilitating a comfortable and supportive environment for these vital conversations. Project evaluations and observations revealed that the Festivals, and the activities co-created by the young ambassadors helped to facilitate spontaneous conversations about death, dying and bereavement amongst young people by providing a comfortable and supportive environment. The project was funded by the Arts and Humanities Research Council (AH/V008609/1), building on a pilot project funded by the Higher Education Innovation Fund at the University of Bradford.
Predictive Power of XGBoost_BiLSTM Model: A Machine-Learning Approach for Accurate Sleep Apnea Detection Using Electronic Health Data
Authors: Javeed Ashir , Berglund Johan Sanmartin , Dallora Ana Luiza , Saleem Muhammad Asim , Anderberg Peter 
Published: November 2023

AbstractSleep apnea is a common disorder that can cause pauses in breathing and can last from a few seconds to several minutes, as well as shallow breathing or complete cessation of breathing. Obstructive sleep apnea is strongly associated with the risk of developing several heart diseases, including coronary heart disease, heart attack, heart failure, and stroke. In addition, obstructive sleep apnea increases the risk of developing irregular heartbeats (arrhythmias), which can lead to low blood pressure. To prevent these conditions, this study presents a novel machine-learning (ML) model for predicting sleep apnea based on electronic health data that provides accurate predictions and helps in identifying the risk factors that contribute to the development of sleep apnea. The dataset used in the study includes 75 features and 10,765 samples from the Swedish National Study on Aging and Care (SNAC). The proposed model is based on two modules: the XGBoost module assesses the most important features from feature space, while the Bidirectional Long Short-Term Memory Networks (BiLSTM) module classifies the probability of sleep apnea. Using a cross-validation scheme, the proposed XGBoost_BiLSTM algorithm achieves an accuracy of 97% while using only the six most significant features from the dataset. The model’s performance is also compared with conventional long-short-term memory networks (LSTM) and other state-of-the-art ML models. The results of the study suggest that the proposed model improved the diagnosis and treatment of sleep apnea by identifying the risk factors.
EuroSCORE II for Risk Evaluation and Predicting Cardiac Intensive Care Length of Stay in Indian Patients Undergoing Adult Cardiac Surgery
Authors: Kate Shreyas , Shouche Sachin , Singh Shalendra , Sharma Rakesh , Naseem Sufia , Sood Munish , Taank Priya 
Published: November 2023

Abstract
Background
Higher EuroSCORE II values are usually associated with increased postoperative morbidity and longer durations of Cardiac intensive care unit (CICU) stay following cardiac surgery.

Aim/Purpose
The aim is to investigate the predictive performance of EuroSCORE II for the Indian population and its relationship with ICU length of stay.

Methods
Prospective, observational study in 250 adult cardiac patients undergoing CABG under general Anaesthesia. Preoperatively values of EuroSCORE II was calculated by an online calculator available on www.euroscore.org. These patients were followed up after surgery for 30 days to note mortality and length of CICU stay.

Results
Of 250 cases studied, 39 (15.6%) had EuroSCORE II less than 1, 163 (65.2%) had EuroSCORE II between 1 and 3, 36 (14.4%) had EuroSCORE II between 3.1 and 5.0 and 12 (4.8%) had EuroSCORE II more than 5 in the study group. Mean EuroSCORE II and length of stay in CICU after surgery was 2.2 ± 1.4 and 4.2 ± 2.5 days respectively. The area under the curve (AUC) for EuroSCORE II as a sole predictor of mortality in the study group based on receiver operating characteristic curve (ROC) analysis was 0.919 (95% CI 0.86–0.97). Based on ROC analysis, AUC is significantly higher for predicting mortality (p < 0.001).

Conclusion
EuroSCORE II in Indian cardiac patients undergoing cardiac surgery is lesser than in European patients (mean 2.2 vs 3.7). Incidence of mortality is higher in patients with higher EuroSCORE II. As per our study patients with higher EuroSCORE II tend to stay longer in ICU.
Impact of the Core Deformation on the Tidal Heating and Flow in Enceladus' Subsurface Ocean
Authors: Aygün Burak , Čadek Ondřej 
Published: November 2023

AbstractWe present a novel approach to modeling the tidal response of icy moons with subsurface oceans. The problem is solved in the time domain and the flow in the ocean is calculated simultaneously with the deformation of the core and the ice shell. To simplify the calculations, we assume that the internal density interfaces are spherical and the effective viscosity of water is equal to or greater than 100 Pa s. The method is used to study the effect of an unconsolidated core on tidal dissipation in Enceladus' ocean. We show that the partitioning of tidal heating between the core and the ocean strongly depends on the thickness of the ocean layer. If the ocean thickness is significantly greater than 1 km, heat production is dominated by tidal dissipation in the core and the amount of heat produced in the ocean is negligible. In contrast, when the ocean thickness is less than about 1 km, tidal heating in the core diminishes and dissipation in the ocean increases, leaving the total heat production unchanged. Extrapolation of our results to realistic conditions indicates that tidal flow is turbulent which suggests that the linearized Navier‐Stokes equation may not be appropriate for modeling the tidal response of icy moons. Finally, we compare our results with those obtained by solving the Laplace tidal equations and discuss the limitations of the two‐dimensional models of ocean circulation.
Reduced Ice Loss From Greenland Under Stratospheric Aerosol Injection
Authors: Moore John C. , Greve Ralf , Yue Chao , Zwinger Thomas , Gillet‐Chaulet Fabien , Zhao Liyun 
Published: November 2023

AbstractSea level rise (SLR) due to surface melt and to dynamic losses from the ice sheets—that is via accelerated flow of glaciers into the sea—is something that may be potentially mitigated by cooling the ice sheet and oceans via solar geoengineering. We use two ice dynamic models driven by changes in surface mass balance (SMB) from four climate models to estimate the SLR contribution from the Greenland ice sheet under the Intergovernmental Panel on Climate Change (IPCC) Representative Concentration Pathway (RCP) 4.5, and 8.5, and Geoengineering Model Intercomparison Project G4 scenarios. The G4 scenario adds 5 Tg/yr sulfate aerosols to the equatorial lower stratosphere (equivalent of 1/4 the 1991 Mt Pinatubo SO2 eruption) to the IPCC RCP4.5 scenario, which itself approximates the greenhouse gas emission commitments agreed in Paris in 2015. Over the 2020–2090 period, mass loss under G4 is about 31%–38% that under RCP4.5, which is 36%–48% lower than under RCP8.5. Ice lost across the grounding line under both G4 and RCP4.5 is reduced in the future as the termini of many southeast Greenland outlets retreat onto bedrock above sea level. Glaciers with large low‐lying catchments in the west, north, and northeast of Greenland (e.g., Jakobshavn, 79N, Zachariae Isstrøm, and Petermann glaciers) discharge more ice from the ice‐sheet interior under RCP4.5 than under G4. Although calving losses vary much more than the SMB difference between ice dynamic models, both models point to significant ice discharge losses of between 15% and 42% across the scenarios.
Reduction of renal interstitial fibrosis by targeting Tie2 in vascular endothelial cells
Authors: Jiang Lu , Hu Xiaohan , Feng Yajun , Wang Zhen , Tang Hanyun , Lin Qiang , Shen Yunyan , Zhu Yun , Xu Qinying , Li Xiaozhong 
Published: November 2023

Abstract
Background
Tie2, a functional angiopoietin receptor, is expressed in vascular endothelial cells and plays an important role in angiogenesis and vascular stability. This study aimed to evaluate the effects of an agonistic Tie2 signal on renal interstitial fibrosis (RIF) and elucidate the underlying mechanisms.

Methods
We established an in vivo mouse model of folic acid-induced nephropathy (FAN) and an in vitro model of lipopolysaccharide-stimulated endothelial cell injury, then an agonistic Tie2 monoclonal antibody (Tie2 mAb) was used to intervent these processes. The degree of tubulointerstitial lesions and related molecular mechanisms were determined by histological assessment, immunohistochemistry, western blotting, and qPCR.

Results
Tie2 mAb attenuated RIF and reduced the level of fibroblast-specific protein 1 (FSP1). Further, it suppressed vascular cell adhesion molecule-1 (VCAM-1) and increased CD31 density in FAN. In the in vitro model, Tie2 mAb was found to decrease the expression of VCAM-1, Bax, and α-smooth muscle actin (α-SMA).

Conclusions
The present findings indicate that the agonistic Tie2 mAb exerted vascular protective effects and ameliorated RIF via inhibition of vascular inflammation, apoptosis, and fibrosis. Therefore, Tie2 may be a potential target for the treatment of this disease.

Impact

This is the first report to confirm that an agonistic Tie2 monoclonal antibody can reduce renal interstitial fibrosis in folic acid-induced nephropathy in mice.

This mechanism possibly involves vascular protective effects brought about by inhibition of vascular inflammation, apoptosis and fibrosis.

Our data show that Tie2 signal may be a novel, endothelium-specific target for the treatment of tubulointerstitial fibrosis.
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
Authors: Gao Xiang , Murphy Malea M. , Peyer James G. , Ni Yuehan , Yang Min , Zhang Yixuan , Guo Jiaming , Kara Nergis , Embree Claire , Tasdogan Alpaslan , Ubellacker Jessalyn M. , Crane Genevieve M. , Fang Shentong , Zhao Zhiyu , Shen Bo , Morrison Sean J. 
Published: November 2023

AbstractThe bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated. Here we found that nerve growth factor (NGF) produced by leptin receptor-expressing (LepR+) stromal cells is required to maintain nerve fibres in adult bone marrow. In nerveless bone marrow, steady-state haematopoiesis was normal but haematopoietic and vascular regeneration were impaired after myeloablation. LepR+ cells, and the adipocytes they gave rise to, increased NGF production after myeloablation, promoting nerve sprouting in the bone marrow and haematopoietic and vascular regeneration. Nerves promoted regeneration by activating β2 and β3 adrenergic receptor signalling in LepR+ cells, and potentially in adipocytes, increasing their production of multiple haematopoietic and vascular regeneration growth factors. Peripheral nerves and LepR+ cells thus promote bone marrow regeneration through a reciprocal relationship in which LepR+ cells sustain nerves by synthesizing NGF and nerves increase regeneration by promoting the production of growth factors by LepR+ cells.
Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial
Authors: Duch Raymond , Asiedu Edward , Nakamura Ryota , Rouyard Thomas , Mayol Alberto , Barnett Adrian , Roope Laurence , Violato Mara , Sowah Dorcas , Kotlarz Piotr , Clarke Philip 
Published: November 2023

AbstractWe implemented a clustered randomized controlled trial with 6,963 residents in six rural Ghana districts to estimate the causal impact of financial incentives on coronavirus disease 2019 (COVID-19) vaccination uptake. Villages randomly received one of four video treatment arms: a placebo, a standard health message, a high cash incentive (60 Ghana cedis) and a low cash incentive (20 Ghana cedis). For the first co-primary outcome—COVID-19 vaccination intentions—non-vaccinated participants assigned to the cash incentive treatments had an average rate of 81% (1,733 of 2,168) compared to 71% (1,895 of 2,669) for those in the placebo treatment arm. For the other co-primary outcome of self-reported vaccinations 2 months after the initial intervention, the average rate for participants in the cash treatment was 3.5% higher than for participants in the placebo treatment (95% confidence interval (CI): 0.001, 6.9; P = 0.045): 40% (602 of 1,486) versus 36.3% (672 of 1,850). We also verified vaccination status of participants: in the cash treatment arm, 36.6% (355 of 1,058) of verified participants had at least one dose of the COVID-19 vaccine compared to 30.3% (439 of 1,544) for those in the placebo—a difference of 6.3% (95% CI: 2.4, 10.2; P = 0.001). For the intention and the vaccination outcomes, the low cash incentive (20 Ghana cedis) had a larger positive effect on COVID-19 vaccine uptake than the high cash incentive (60 Ghana cedis). Trial identifier: AEARCTR-0008775.
Real-world treatment outcome of direct-acting antivirals and patient survival rates in chronic hepatitis C virus infection in Eritrea
Authors: Ghebremeskel Ghirmay Ghebrekidan , Berhe Solomon Michael , Achila Oliver Okoth , Mengistu Samuel Tekle , Asmelash Rahel Frezghi , Berhane Mesfin Araia , Hamida Mohammed Elfatih 
Published: November 2023

AbstractReliable real-world data on direct acting anti-retroviral (DAA) uptake and treatment outcomes are lacking for patients with hepatitis C virus (HCV) in sub-Saharan Africa. This study provides data on HCV DAA-based treatment outcomes, mortality, loss-to-follow up, and associated factors among patients in Eritrea. A multicenter retrospective observational cohort study was conducted in two tertiary hospitals in Asmara, Eritrea. A structured checklist was used to collect data from patient’s cards. Descriptive and inferential statistics used included means (± Standard deviation (SD), medians (Interquartile range (IQR), chi-squire (χ2), Kaplan–Meier estimates, and multivariate Cox proportional hazard models. A total of 238 patients with median age of 59 years (IQR 50–69 years) were enrolled in the study. Out of the 227 patients initiated on treatment, 125 patients had viral load measurements at 12 weeks after end of treatment (EOT) whereas 102 patients had no viral load measurements at 12 weeks EOT. Among the patients with HCV RNA data post-EOT 12, 116 (92.8%) had sustained viral response (SVR). The prevalence of death and loss-to-follow up (LTFU) were (7.5%, 95% CI 1.7–4.1) and 67 (28.1%, 95% CI 22.3–33.9) translating into an incidence of 1.1 (95% CI 0.8–1.5) per 10,000 person days. Independent predictors of LTFU included the enrollment year (2020: aHR = 2.2, 95% CI 1–4.7; p value = 0.04); Hospital (Hospital B: aHR = 2.2, 95% CI 1–4.7; p value = 0.03) and the FIB-4 score (FIB-Score < 1.45: aHR = 3.7, 95% CI 1.2–11.5; p value = 0.02). The SVR rates achieved in this cohort were high. However, high LTFU and high mortality driven largely by late presentation and suboptimal population screening/case finding, were uncovered. These challenges can be addressed by test-and-treat programs that simultaneously prioritize programmatic screening, decentralization of care, and better patient tracking in the HCV care cascade.
Radiological landmark of syndesmotic ligament complex by magnetic resonance imaging correlate with fibula free flap harvesting procedure
Authors: Yodrabum Nutcha , Chaikangwan Irin , Tianrungroj Jirapat , Suksantilap Songsak , Chalalaisathaphorn Suttichai , Siriwanarangsun Palanan 
Published: November 2023

AbstractPreservation of syndesmotic ligaments is crucial for preventing adverse sequelae at the donor site following free fibula osteocutaneous flap harvesting. This study sought to determine the relationship between distal tibiofibular ligaments and the fibular segment to identify radiological landmarks that facilitate safe and precise flap. The distances between the distal tibiofibular ligaments (anterior inferior tibiofibular ligament [AITFL], posterior inferior tibiofibular ligament [PITFL]) and the fibular segment, as well as the lower border of the interosseous membrane, were measured on magnetic resonance imaging (MRI) scans of 296 patients without any perceivable ankle abnormalities. The mean distances (± SD) between the distal end of the fibula and the AITFL, PITFL, and lower interosseous membrane border were 3.0 ± 0.4 cm, 2.6 ± 0.4 cm, and 3.9 ± 0.6 cm, respectively. The distance between the talar dome and the PITFL exhibited a range of 0.0–0.5 cm. Our findings support preserving a distal fibular remnant of at least 4 cm to avoid injury to the syndesmotic ligament throughout fibula osteocutaneous flap harvesting. The talar dome could serve as a useful radiological landmark for identifying the upper border of PITFL during preoperative evaluation, and thus facilitating precise and safe flap procurement.
Effects of family-based diabetes self-management education and support programme on support behaviour amongst adults with type 2 diabetes in Western Ethiopia
Authors: Diriba Dereje Chala , Leung Doris Y. P. , Suen Lorna K. P. 
Published: November 2023

AbstractSupport from family and peers may enhance the outcomes of diabetes management. This study reported the preliminary effect of a family-based diabetes self-management education and support (DSMES) programme on the perceived support status of people with diabetes and the family’s caregiver support behaviour amongst dyads living in Western Ethiopia. A 1:1 two-armed pilot randomised controlled trial (RCT) was conducted. A total of 76 dyads were recruited using the convenience sampling method and randomly assigned to either intervention or control groups. The control group continued the usual care, whereas the intervention group continued the usual care and additionally received a 12-h social cognitive theory (SCT)-guided, family-supported DSMES programme in the community. Generalised estimating equations models were computed to test the preliminary effects of the DSMES programme on the outcomes. P-value < 0.05 was set as statistically significant. The pilot RCT shows a statistically significant between-group difference in the changes in support needed at T1 (d = 0.88) and T2 (d = 1.35) and support received at T1 (d = 0.88) and T2 (d = 1.44). The DSMES programme has outperformed usual care with a medium effect size at T1 (d = 0.54) and a large effect size at T2 (d = 0.97) on the family’s supportive behaviour. Although the intervention group was not statistically significant at T1 (d = 0.43), a large effect size was obtained at T2 (d = 0.97) on the family’s non-supportive behaviour. A SCT-guided, family-supported DSMES programme produced a promising positive effect on enhancing the support needed and support received from their family/friends, and it also improved the family’s supportive behaviour. Thus, family support could be incorporated into DSMES programmes for diabetes management in Western Ethiopia. The trial was registered by the Chinese Clinical Trial Registry (http://www.chictr.org.cn); Registration number: ChiCTR2000040292.
Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma
Authors: Batchu Sai , Hanafy Khalid A. , Redjal Navid , Godil Saniya S. , Thomas Ajith J. 
Published: November 2023

AbstractGlioblastoma (GBM) is an aggressive primary CNS malignancy and clinical outcomes have remained stagnant despite introduction of new treatments. Understanding the tumor microenvironment (TME) in which tumor associated macrophages (TAMs) interact with T cells has been of great interest. Although previous studies examining TAMs in GBM have shown that certain TAMs are associated with specific clinical and/or pathologic features, these studies used an outdated M1/M2 paradigm of macrophage polarization and failed to include the continuum of TAM states in GBM. Perhaps most significantly, the interactions of TAMs with T cells have yet to be fully explored. Our study uses single-cell RNA sequencing data from adult IDH-wildtype GBM, with the primary aim of deciphering the cellular interactions of the 7 TAM subtypes with T cells in the GBM TME. Furthermore, the interactions discovered herein are compared to IDH-mutant astrocytoma, allowing for focus on the cellular ecosystem unique to GBM. The resulting ligand-receptor interactions, signaling sources, and global communication patterns discovered provide a framework for future studies to explore methods of leveraging the immune system for treating GBM.
Enhancing maize productivity by mitigating alkaline soil challenges through acidified biochar and wastewater irrigation
Authors: ul Shahid Zain , Ali Muqarrab , Shahzad Khurram , Danish Subhan , Alharbi Sulaiman Ali , Ansari Mohammad Javed 
Published: November 2023

AbstractIn alkaline soil conditions, the availability of essential nutrients for plant growth becomes limited, posing a significant challenge for achieving optimal maize growth and yield. Exploring the impact of biochar and waste irrigation on soil alkalinity and maize production in arid regions has received limited attention. This study aimed to evaluate the effects of three levels of acidified biochar (0, 5, and 10 Mg ha−1) in two growing seasons of maize—spring and autumn. The treatments were applied following a randomized complete block design with three replications. Biochar was applied only in the autumn season, and its residual effects were evaluated in the spring season. The study found that using acidifying biochar at a rate of 10 Mg ha−1 significantly increased maize yield by 35.8% compared to no application and by 16.4% compared to a rate of 5 Mg ha−1. In the autumn, applying acidified biochar at 10 Mg ha−1 reduced soil pH by 3.65% and 6.41% compared to 0 and 5 Mg ha−1. In the spring, the same application led to a decrease in soil pH by 5.84% and 7.37% compared to the lower rates. Additionally, using 10 Mg ha−1 of acidifying biochar increased soil phosphorus concentration by 87.6% and soil potassium concentration by 38.0% compared to not using biochar, and by 46.2% and 35.0% compared to the 5 Mg ha−1 application. These findings suggest that the reduction of soil pH by applying biochar at a rate of 10 Mg ha−1 facilitated an increase in nutrient availability in the soil, consequently leading to higher maize yield. Notably, no significant differences were observed in maize productivity and soil properties between the spring and autumn seasons. Therefore, this study paves the way for further exploration into the long-term effects of acidifying biochar on maize productivity and soil properties in similar agroecological contexts.