bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggregated epigenetic profiles explain the intergenerational transmission of physical neglect with psychiatric, cognitive, and bonding effects.
Authors: León Inmaculada , Góngora Daylín , Rodrigo María José , Herrero-Roldán Silvia , López Maykel , Mitchell Colter , Fisher Jonah , Medina Yasser Iturria 
Published: December 2023

Abstract
BACKGROUND. Past experiences of maltreatment and life adversity have been shown to induce DNA methylation changes in adults, but less is known about their impact on mothers’ maladaptive neglectful parenting.
METHODS. We performed an epigenome-wide association study (EWAS) to investigate the role of DNA methylation levels in the intergenerational association between mothers’ past experience of childhood neglect and current maternal neglect behavior. Saliva DNA methylation was determined with the Illumina Human Methylation EPIC BeadChip. We used a trajectory inference method to derive a personalized aggregated epigenetic maternal neglect score (EMNs) from 138 mothers (n=51 in the neglect group; n=87 in the control non-neglect group) having young children. Differential methylation between groups was utilized to derive the EMNs, adjusting for education level, age, experimental variables, and blood cell types in saliva samples.
RESULTS. Structural equation modelling: X2 (29) =39.590; p=0.091; RMSEA=0.052, confirmed the EMNs as a mediator between the neglectful mothers’ past experience of physical neglect and current reports of psychopathological symptoms, poor cognitive integrity, and observed poor mother-child emotional availability. A third of the genes annotated to the CpGs that affect EMNs are related to cognitive impairment and neurodegenerative and psychopathological disorders.
CONCLUSIONS. EMNs is a novel index to assess the contribution of DNA methylation changes to the intergenerational transmission of neglectful parenting behavior and its negative effects. The evidence provided expands the possibilities for earlier interventions on the neglect condition to prevent and ameliorate the impact of maternal adversities on mother-child care, helping to break the cycle of maltreatment.
A new primordial noble gas component in the solar system discovered in Ryugu asteroid
Authors: Verchovsky Alexander , Abernethy Feargus , Anand Mahesh , Franchi Ian , Grady Monica , Greenwood Richard , Barber Simeon , Suttle Martin , Ito Motoo , Tomioka Naotaka , Uesugi Masayuki , Yamaguchi Akira , Kimura Makoto , Imae Naoya , Shirai Naoki , Ohigashi Takuji , Liu Ming-Chang , Uesugi Kentaro , Nakato Aiko , Yogata Kasumi , Yuzawa Hayato , Karouji Yuzuru , Nakazawa Satoru , Okada Tatsuaki , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Yoshikawa Makoto , Miyazaki Akiko , Nishimura Masahiro , Yada Toru , Abe Masanao , Usui Tomohiro , Watanabe Sei-ichiro , Tsuda Yuichi 
Published: December 2023

Abstract

Ryugu is the C-type asteroid from which material was brought to Earth by the Hayabusa2 mission. A number of individual grains and fine-grained samples analysed so far for noble gases have indicated that solar wind and planetary (P1=Q) noble gases are present in Ryugu samples with concentrations higher than those observed in CIs, suggesting the former to be more primitive compared to the latter. We analysed three fine-grained samples from Ryugu, one of which contained a Xe concentration an order of magnitude higher (4x10-7 cc STP/g) than previously found in samples from Ryugu. Isotopically, this Xe resembles Q, but with a much stronger (by a factor of four) isotopic fractionation relative to solar wind and an 36Ar/132Xe ratio at least an order of magnitude lower than in P1. This new planetary primordial noble gas component (here termed P7) provides clues to constrain how the solar composition was fractionated to form the planetary components.
Copula lucentia sp. nov., a new box jellyfish (Cnidaria: Cubozoa: Carybdeida) from Western Mediterranean Sea
Authors: Bordehore Cesar , Fonfría Eva S. , Straehler-Pohl Ilka , Stampar Sérgio N. , Collins Allen G. , Hoverd William Alan 
Published: December 2023

Abstract

A new species of box jellyfish, Copula lucentia sp. nov., is described from El Campello, Alicante, Spain and compared to the holotype of Copula sivickisi that was successfully recovered after being lost for almost 60 years. So far, the only cubozoan species recorded in the Western Mediterranean was Carybdea marsupialis. The genus Copula just included the type species (Copula sivickisi) reported from different temperate, tropical and subtropical localities in the Pacific, Atlantic and Indian Oceans. Morphologically, this new species possesses the typical characteristics of the genus Copula (four adhesive pads on the apex and a vertical keyhole-shaped rhopalial niche ostium) but it can be differentiated from the C. sivickisi holotype by the velarial canal pattern. In C. lucentia the velarial canal roots taper towards the velarial rim and each root bears 1–2 narrow triangular canals with sharp tips, resembling a bird-beak. In contrast, the velarial canal roots of C. sivickisi bear 2 short, broad canals that increase breadth towards the velerial rim and split up into 3 to 6 lobed, finger-like canals with rounded tips, giving the canal pattern a paw-like appearance. Molecular analyses of mitochondrial cytochrome c oxidase subunit I (COI) and nuclear 16S ribosomal DNA genes show that there are even more Copula species than expected, but which will not be focused on here. This study highlights not only that there are species yet to be discovered in the Mediterranean Sea, one of the most studied seas worldwide, but that a revision of the genus Copula is necessary.
Design, Formulation, Evaluation and Statistical Optimization of Coated Floating Pulsatile Tablets for Modified Chronopharmacotherapy of Rheumatoid Arthritis
Authors: jyothirmayi pasam 
Published: December 2023

Abstract
Background
Rheumatoid arthritis is the condition needs early morning medication according to biorhythms. Hence, the main aim of designing Coated Floating Pulsatile Tablets (CFPT) of Tramadol hcl for statistical optimization and to perform in vitro and in vivo buoyancy evaluation for modified chronopharmacotherapy of rheumatoid arthritis.
Methods
The formulation was designed with the immediate core covered with a compression coat followed by the upper buoyant and immediate layer. The best formulations of core tablets were compression coated with polymer HPMC K15M, Ispaghula gum (IG), and Tamarindus gum (TG) to assign a suitable lag time for formulation. HPMC K100M, Ispaghula gum, and their combination were compressed as the buoyant layers. Statistical optimization was done on parameters such as BLT, TFT, %SI, and % CDR.
Results
Immediate release layer and core tablets were optimized with formulation IF2 which contains sodium starch Glycolate 8%, and then in compression coated buoyant formulation CFPT was optimized by DoE optimization showing BL8 exhibiting good floating behavior and lag time, drug release for a period of 11 hrs.
Conclusion
As the formulation showed delay in drug release in vitro and also showed in vitro buoyancy, hence nighttime administration could be beneficial to reduce the rheumatoid arthritis complications in the early morning.
Experimental Behaviour of Prestressed Concrete Beams Under Simultaneous Sustained Loading and Corrosion
Authors: Rinaldi Zila , Carlo Fabio Di , Meda Alberto , Molaioni Filippo 
Published: December 2023

Abstract
The paper presents an experimental study for the evaluation of the flexural response and failure mode of a prestressed concrete (PC) beam subjected to simultaneous sustained loads and corrosion. The obtained results are judged and discussed also through a comparison with the experimental outcomes on a reference sound PC beam, and a companion specimen subjected to artificial corrosion first, and then tested in bending. The three specimens are characterized by a 200 x 300 mm rectangular cross section, a total length of 3700 mm and a clear span of 2700 mm. The value of the sustained load, applied with a simultaneous accelerated corrosion process of the strands, was chosen, based on the result of the uncorroded reference beam, to achieve a crack width of about 0.2 mm. The flexural response of the tested element was monitored over a period of 70 days, up to failure, and showed to be highly dependent on the localization of the corrosion phenomena affecting the strands, especially when coinciding with the maximum bending moment position. The obtained results are finally compared to the ones obtained on a PC beam with the same geometry and material properties, firstly subjected to corrosion and then tested in bending. The differences in corrosion morphology and location, and in the failure mode of the strand confirm the importance of accounting for the combined effect of reinforcement corrosion and loading when assessing the structural performance of prestressed concrete beams.
Alleviating coral thermal stress via inoculation with quorum quenching bacteria
Authors: Yang Qingsong , Yang Bing , Yang Bin , Zhang Wenqian , Tang Xiaoyu , Sun Huiming , Zhang Yanying , Li Jie , Ling Juan , Dong Junde 
Published: December 2023

Abstract

In the background of global warming, coral bleaching induced by elevated seawater temperature is the primary cause of coral reef degradation. Coral microbiome engineering using the beneficial microorganisms for corals (BMCs) has become a hot spot in the field of coral reef conservation and restoration. Investigating the potential of alleviating thermal stress by quorum quenching (QQ) bacteria may provide more tools for coral microbial engineering remediation. In this study, QQ bacteria strain Pseudoalteromonas piscicida SCSIO 43740 was screened among 75 coral-derived bacterial strains, and its quorum sensing inhibitor (QSI) compound was isolated and identified as 2,4-di-tert-butylphenol (2,4-DTBP). Then, the thermal stress alleviating potential of QQ bacteria on coral Pocillopora damicornis was tested by a 30-day controlled experiment with three different treatments: control group (Con: 29°C), high temperature group (HT: 31°C), and the group of high temperature with QQ bacteria inoculation (HTQQ: 31°C + QQ bacteria). The results showed that QQ bacteria SCSIO 43740 inoculation can significantly mitigate the loss of symbiotic algae and impairment of photosynthesis efficiency of coral P. damicornis under thermal stress. In addition, QQ bacteria inoculation suppressed the coral microbial community beta-dispersion and improved the stability of microbial co-occurrence network under thermal stress. It was suggested that QQ bacteria inoculation can alleviate coral thermal stress via reshaping microbial interaction and maintain community stability of coral microbiome. This study provided new evidence for the probiotic function of QQ bacteria in corals, which shedding light on the development of new microbiological tools for coral reef conservation.
Biofabrication of iron oxide nanoparticles from green seaweed Ulva lactuca and screening for its insecticidal activity
Authors: S Ramya , M Narayanasamy , L Eaban Eamy G. , G Chandrasekar , R Palanivelan 
Published: December 2023

Abstract
The primary aim of the research was to utilize Ulva lactuca, green seaweed, to biofabricate iron oxide nanoparticles (FeNP) and evaluate their insecticidal efficacy against Tuta absoluta, a pest that primarily impact tomato commercial crop. For the purpose of characterising biosynthesized nanoparticles, tools such as UV-Vis spectroscopy, FT-IR, XRD, SEM, and TEM were used. Inferred from the results is that, the aggregation of iron oxide nanoparticles is confirmed by the colour change from yellow to dark brown. Additionally, spectra from the 200–1000 range are absorbed by UV–Vis spectroscopy. The FT-IR peaks correspond to the band at 778 cm in the Ulva lactuca extract and correspond to F-O stretches of Fe2O3, confirming the production of nanoparticles. The band at 2851 cm may be due to C-N stretching from unreacted impurities or CO2 in the sample compartment. According to a TEM image of iron nanoparticles, the majority of these particles are almost spherical in shape, and their average size was found to be between 50 and 250 nm. Pure iron oxide nanoparticles were recovered from Ulva lactuca by green synthesis. The prominent peaks in the range of 30 to 70θ indicated by XRD demonstrate the extraction of pure iron oxide nanoparticles from Ulva lactuca. The results of the insecticidal tests indicate that the synthesised iron oxide nanoparticles had a satisfactory death rate of 63% with an observed concentration of 77.32 ppm. The values for the LC50 are 97.25 and LC90 are 110.8 ppm. The values were compared one to the other with the control. The insect Tuta absoluta will be a possible target for control with iron oxide nanoparticles generated from Ulva lactuca.
A Dual-controlled Guest Release from Cages
Authors: Wang Ying , Yao Yuqing , Shao Chengyuan , Wang Shuwei , Gong Qiufang , Liu Jia , Jiang Hua 
Published: December 2023

Abstract
Despite having significant applications in the construction of controlled delivery systems with high anti-interference capability, dual-controlled molecular release has not yet been achieved based on small molecular/supramolecular entities. Herein, we report a dual-controlled release system based on coordination cages, for which releasing the guest from the cage demands synchronously altering the coordinative metal cations and the solvent. The cages, Hg5L2 and Ag5L2, are constructed via coordination-driven self-assembly of a corannulene-based ligand. While Hg5L2 shows a solvent-independent guest encapsulation in all the studied solvents, Ag5L2 is able to encapsulate the guests in only some of the solvents, such as acetone-d6, but will liberate the encapsulated guests in 1,1,2,2-tetrachloroethane-d2. Hg5L2 and Ag5L2 are interconvertible. Thus, the release of guests from Hg5L2 in acetone-d6 can be achieved, but requires two separate operations, including metal substitutions and a change of the solvent. In chemistry, dual-controlled systems such as this have the potential in programmable synthesis, cooperating with single-controlled guest release systems to sequentially release different reactants/catalysts.
Corticosteroids for improving patient relevant outcomes in HELLP syndrome: a systematic review and meta-analysis
Authors: Kasem Asmaa Fahmy , Alqenawy Hamdy Bakry , Elgendi Marwa Abdelmawla , Ali Radwa Rasheedy , Ahmed Rania Hassan Mostafa , Sorour Mohammad Nahel , Hegab Khadiga Mostafa Hussein , El-skaan Rania Gamal Anwar , Helw Rowyna Hany Mohamed El , Elsewefy Mohamed Sameh , Abdelrazek Maya Mahmoud , Elrefaey Yasser Mostafa Mahmoud , Albahaie Mohamed Yasser Galal , Salama Mohamed Hamed , Nabhan Ashraf Fawzy 
Published: December 2023

Abstract

Background: We conducted this updated systematic review to assess the effects of corticosteroids vs placebo or no treatment for improving patient-relevant outcomes in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome.
Methods: CENTRAL, MEDLINE/PubMed, Web of Science, and Scopus, from the date of inception of the databases to September 20, 2023 were searched. Reference lists of included studies and systematic reviews were thoroughly searched. We included RCTs that enrolled women with HELLP syndrome, whether antepartum or postpartum, to receive any corticosteroid versus placebo or no treatment. No language or publication date restrictions were made. We used a dual independent approach for screening titles and abstracts, full text screening, data extraction, and risk of bias assessment. Pairwise meta-analyses were conducted, where two or more studies met methodological criteria for inclusion. GRADE approach was used to assess certainty of evidence for the pre-specified outcomes.
Results: Fifteen trials (821 women) compared corticosteroids with placebo or no treatment. The effect of corticosteroids is uncertain for the primary outcome i.e., maternal death (risk ratio [RR] 0.77, 95% confidence interval [CI] 0.25 to 2.38, very low certainty evidence). The effect of corticosteroids is also uncertain for other important outcomes including pulmonary edema, dialysis, liver morbidity (hematoma, rupture, and failure), or perinatal death because of very low certainty evidence. Low certainty evidence suggests that corticosteroids have little or no effect on the need for platelet transfusion and may result in a slight reduction in acute renal failure.
Conclusions: In women with HELLP syndrome, the effect of corticosteroids vs placebo or no treatment is uncertain for patient-relevant outcomes including maternal death, maternal morbidity, and perinatal death. These uncertainties regarding this critical question should be addressed by adequately powered rigorous trials.
Systematic review registration: Center for Open Science, osf.io/yzku5
Synergic Light-Induced Electron Transfer and [4 + 4] Cycloaddition toward Switchable Photoluminescence and Single-Molecule Magnet Behavior in a Dy4 Cubane
Authors: Wang Guo-Ming , Gao Zhen-Ni , Wang Yu-Han , Li Jie , Wei Wu-Ji , Han Songde , Zhang Yi-Quan , Hu Ji-Xiang 
Published: December 2023

Abstract
Molecular materials possessing switchable magneto-optical properties are of great interest for their potential applications in spintronics and molecular devices. However, switching their photoluminescence (PL) and single-molecule magnet (SMM) behavior via light-induced structural changes still constitutes a formidable challenge. Herein, a series of cubane structures were synthesized via self-assembly of anthracene acid and rare-earth ions under hydrothermal conditions. Upon Xe lamp irradiation at room temperature, all complexes exhibited obvious photochromic phenomena and complete PL quenching, which were realized via the synergistic effect of photogenerated radicals and [4 + 4] photocycloaddition of Ac components, with the quenched PL showing the largest fluorescence intensity change (99.72%) in electron-transfer photochromic materials. A reversible decoloration process was unexpectedly achieved via mechanical grinding stemming from the relaxation of photogenerated radicals. Moreover, an SMM behavior in the Dy analog appeared after room-temperature irradiation owing to the photocycloaddition of Ac ligands and photogenerated stable radicals changed the electrostatic ligand field and magnetic couplings. This work realizes for the first time complete PL quenching and photoinduced SMM behavior via simultaneous modulation of photocycloaddition and photogenerated radicals in one system, providing a dynamical switch for the construction of multifunctional polymorphic optical response materials and optical storage devices.
Osimertinib-associated Membranoproliferative Glomerulonephritis: a Case Report
Authors: GUO HENRY , YEUNG EMILY , BRANLEY PAULINE , LING JONATHAN 
Published: December 2023

Abstract
Osimertinib is a third-generation epidermal growth factor receptor-directed tyrosine kinase inhibitor (EGFR-TKIs) that selectively binds to T790M mutation and used in EGFR-positive non-small cell lung cancer (NSCLC), which has shown to improve progression-free survival. While there have been reports of first- and second-generation EGFR-TKIs causing acute tubulointerstitial nephritis, there have been limited case reports of osimertinib-associated glomerular injury. We describe a case of osimertinib-associated membranoproliferative glomerulonephritis (MPGN) in a patient with advanced Stage IV NSCLC and severe acute kidney injury (AKI), that responded with osimertinib cessation and a course of oral prednisolone. Thus, we recommend a renal biopsy in patients with an acute kidney injury suspected to osimertinib use.
Enhancing fire resistance in wood with high-water retention silica gel: A promising flame-retardant solution
Authors: Fei Zhongbin , Zhang Yingnan , Wang Zhi , Duan Yiling , Zhang Bin 
Published: December 2023

Abstract
Wood is highly susceptible to fire due to its flammability, causing serious casualties and property damage; therefore, wood treated with fire retardants will be a major issue. In this work, the refractory properties of silica gel with a high water retention capacity were investigated. Testing the water retention while taking into account the characteristics of the silica gel by researching the impact of varied component concentrations. Furthermore, various analytical approaches were used to explore the flame-retardant mechanism of silica gel. According to the experimental findings, silica gel features an abundance of hydrophilic groups and amorphous silica, resulting in a boost in the number of water molecules on its surface. In addition, at high temperatures, silica gel also aids in the formation of a SiO2 layer and a charred layer that serve as an oxygen barrier. This layer protects the wood from combustion. At the same flame temperature, the overall weight degradation of wood treated with silica gel was decreased by 36% and 53%, suggesting that silica gel may prevent the decomposition of wood by heat response. Overall, the study provides valuable insights into the flame-retardant mechanism of silica gel and its potential application in enhancing the fire resistance of wood.
The demethylation of genes antagonized by TET1 in the regulation of the Wnt/β-catenin signaling pathway impacts the biological characteristics of colorectal cancer.
Authors: Wang Kaiyun , Ding Hui , Guo Kaiwen , Chen Qiongrong , Qiu Wenhong , Chen Siyang 
Published: December 2023

Abstract
The TET family is a ten-eleven translocation family of dioxygenases that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and other oxidation products to regulate DNA methylation. Our data revealed significant downregulation of TET1 expression in CRC issues and SW480 cells. The database highlighted mutations as the primary mode of alteration of TET1 in CRC. The bioinformatics analysis results revealed a significant association between TET1 and immune cell infiltration, while indicating that the expression levels of immune checkpoint-related genes in CRC tissues tend to be elevated in comparison to normal tissues. Upon transfection, overexpression of TET1 exerted a comprehensive inhibitory effect by suppressing cell proliferation, inducing apoptosis, hindering migration and invasion, arresting cell cycle progression, and attenuating the activity of the Wnt/β-catenin signaling pathway as well as in nuclear β-catenin expression. Overexpression of TET1 increased 5hmC levels while simultaneously decreasing 5mC levels. We revealed antagonistic genes SFRP2 and WIF1 within the Wnt/β-catenin signaling pathway, which have a significant increase in expression level and a decrease in hypermethylation level upon TET1 overexpression. In conclusion, TET1 exerts its antitumor function by inhibiting the activity of Wnt/β-catenin signaling pathways through demethylation of the antagonistic genes SFRP2 and WIF1. This modulation has a significant impact on the biological properties of CRC.