bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENDOSCOPIC TREATMENT FOR EARLY COLORECTAL CANCER
Authors: Batyrbekov K. , Galiakbarova A. 
Published: January 2024

Relevance: In recent years, significant breakthroughs have occurred in the endoscopic treatment of cancerous and precancerous lesions of the gastrointestinal tract. Endoscopic mucosal resection (EMR) is a simple and effective method of treating most benign gastrointestinal tract lesions. However, with the introduction of endoscopic submucosal dissection (ESD) and full-thickness endoscopic resection (EFTR), the volume of lesions subject to endoscopic treatment has significantly expanded even in the colon. Currently, these methods are regularly used not only for the treatment of benign tumors but also for complex resection of early stages of colorectal cancer. For the first time in Kazakhstan, the presented article analyzed the cases of endoscopic removal of epithelial formations of the large intestine performed at an oncological clinic from 2020 to 2023.
The aim was to evaluate the use of endoscopic treatment of early colorectal cancer.
Methods: The article presents a retrospective analysis of 68 cases of endoscopic removal of epithelial formations of the colon performed from 2020 to 2023 at the Center of Expert Endoscopy and Interventional Radiology of the National Scientific Cancer Center (Astana, Kazakhstan).
Results: In 2020-2023, 68 endoscopic extractions of colon tumors were performed, including 25 outpatient and 43 inpatient manipulations. Out of 43 inpatient cases, endoscopic dissection in the submucosal layer was performed in 9 cases, and endoscopic mucosal resection of tumors of the large intestine was performed in 34 cases. Morphologically, we found hyperplastic polyps in 11 cases, lipomas in 2 cases, tubulovillous adenomas with mild dysplasia – 43 cases, tubulovillous adenomas with severe dysplasia – 11 cases, carcinoma in situ – 3 cases, and adenocarcinoma with invasion – 3 cases.
Conclusion: When detecting benign neoplasms with dysplasia and early colorectal cancer, minimally invasive technologies (EMR, ESD, EFTR) should be the first preferred treatment method and only if they cannot be performed and there is a high risk of invasion into the underlying layers, and therefore, if endoscopic treatment is not radical, clinicians should choose surgical radical treatment. Patients should be informed about the availability of the latest methods of local treatment in the Republic through the financing of the Compulsory Medical Insurance Fund (CMIF).
MAJOR REASONS FOR HOSPITALIZATION TO ICU OF CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A LITERATURE REVIEW
Authors: Kurakbayev Ye. , Turdaliyeva B. , Umbetov K. , Sarsekbayev Ye. 
Published: January 2024

Relevance: Acute lymphoblastic leukemia (ALL) is a common malignancy in children. Approximately 85% of ALLs have B-cell origin, and 15% are T-cell ALLs. Many patients diagnosed with hematologic cancer will require hospitalization in the intensive care unit (ICU) at some point in their treatment.
The aim was to study the available literature on clinical deterioration in patients with АLL admitted to the ICU, the clinical significance and prognostic value of causes of clinical deterioration, and adverse outcomes in patients with АLL staying in the ICU.
Methods: A descriptive cross-sectional study approach was used. We reviewed published sources from 2016 to 2023 to collect data on major reasons for ALL patients’ hospitalization to ICU.
Results: First, the patient’s age at the time of initial diagnosis of ALL is crucial. Cure rates for B-cell ALL are higher between 1 and 9 years of age than in other age groups. Second, the initial white blood cell count during diagnosis is a prognostic indicator. Third, the specific subtype of ALL also affects prognosis. The risk factors emphasize the importance of comorbidities and infectious diseases, as well as monitoring and managing pulmonary and cardiovascular function in patients to avoid hospitalization in the ICU. The main causes of hospitalization in the ICU are complications related to chemotherapy, infection, and unplanned hospitalizations. Compared to normal-risk patients, high-risk patients had a higher rate of OIT hospitalization in the ICU. It is important to control chemotherapy and infections to reduce the number of admissions to the ICU in this group.
Conclusion: Chemotherapy, concomitant and infectious diseases, hypoxia, and hemodynamic instability are reasons for hospitalization of these patients to ICU. The condition of various organs and systems shall be monitored.
PHOTODYNAMIC THERAPY FOR CERVICAL CANCER: A LITERATURE REVIEW
Authors: Shanazarov N. , Bariyeva G. , Mussin N. , Albayev R. , Kaliyev A. , Iztleuov E. , Smailova S. 
Published: January 2024

Relevance: Cervical cancer is a major public health problem worldwide, with human papillomavirus infection playing a vital role as a risk factor. Photodynamic therapy is a minimally invasive treatment for HPV-related cervical lesions that uses photosensitizers and light to selectively destroy abnormal cells.
The study aimed to comprehensively review the different types of molecules used in PDT to reduce the morbidity and mortality associated with cervical cancer.
Methods: A comprehensive search was conducted for all relevant articles investigating the efficacy and safety of PDT in the treatment of HPV-associated cervical cancer. PICO scores were determined for the review, and a literature search of the PubMed database was performed. An examination of the PubMed online database using keyword combinations identified 71 studies conducted between 2013 and 2023 that investigated using PDT to treat RSM cells.
This article reviews ongoing clinical trials examining the efficacy of PDT in treating low-grade squamous cell intraepithelial neoplasia and high-grade squamous cell intraepithelial lesions, as well as preclinical approaches using different molecules for PDT in cervical cancer
Results: Potential molecules for PDT are described, their advantages and disadvantages evaluated, and solutions to improve their compatibility with antitumor treatment are proposed. Our review shows that PDT is a promising therapeutic approach for diagnosing and treating HPV-related cervical lesions. At the same time, we observe that using different classes of dyes enhances the anticancer effects of PDT
Conclusion: Fullerene and ALA-PDT are potential leaders for more intensive use in PDT, which will further help reduce the global incidence and mortality from cervical cancer. However, further studies are needed to evaluate its long-term efficacy and safety.
SALTO: An Expert-Informed Global Trajectory Design and Optimization Toolkit
Authors:   European Space Agency - ESOC, Darmstadt, Germany, Martens Waldemar , Schoenmaekers Johannes , Varga Gábor , Baumgard Colin , Ramírez Torralba Olga , Muñoz Pablo , von Looz Moritz , Mackenzie Ruaraidh 
Published: January 2024

Trajectory design for interplanetary missions is a challenging problem for which a wide range of algorithms have been proposed and used in the past. These algorithms range from completely problem-agnostic solvers, such as genetic algorithms, to methods that incorporate some degree of domain knowledge, like branch and pruning. In this paper, a novel algorithm is presented that is on the opposite side of this spectrum in the sense that it is expert-informed and fully tailored to the trajectory design problem. This algorithm is suitable for solving multi-gravity assist problems with or without thrust, as well as simpler problems like transfers to libration points or lunar missions. Its real-world applicability is enhanced by its ability to design end-to-end trajectories for missions with multiple phases.
The Python implementation of this algorithm, called SALTO (Search Algorithm for Large Trajectory Optimization), is based on two main ideas.
Firstly, the initial guess is only required to solve the problem from an energetic perspective and does not need to solve the phasing problem yet. This allows for large state and time gaps along the trajectory, which are systematically closed in a second step that exploits time shifts by full orbital periods or body rotations. The initial guess itself can be generated by any user-defined algorithm. Currently, implemented guess generators include techniques based on Tisserand Graphs, Lambert solvers, resonant transfer search and indirect methods.
Secondly, the algorithm is not expected to autonomously find all local minima for a problem. Instead, the user defines "tags," or category variables, that guide SALTO's search for solutions by indicating the expected structure of the search space. Examples of tags include the direction of infinite velocity at a planetary flyby, which can take the values “inward” and “outward”, and the resonance ratio of a same-planet transfer. SALTO will attempt to find a solution for all tag combinations in the problem.
SALTO is developed at ESOC as part of the MIDAS package and is Community Open Source (ESA Community License). It is accessible through the space-codev platform for European industry and academia.
Meteosat Third Generation : first AOCS in flight results from PFM-I1 LEOP and commissioning
Authors:   Thales Alenia Space, Cannes La Bocca, France, Dandré Pierre , Pirson Laurent , Ascani Livio , Sechi Gianfranco , Cerone Ernesto , Pessina Stefano 
Published: January 2024

In December 2022, MTG PFM-I1, the first Meteosat Third Generation satellite, aiming at renewing the current Meteosat fleet, was launched on Ariane5 from Kourou, French Guiana. It will be followed by three others MTG-I (Imaging) Satellites and two MTG-S (Sounding) Satellites between 2025 and 2033. The attitude control concept changes from spinning satellites, which was the selected approach for the first and second generations, to a three-axes stabilization, offering better pointing performances as requested by the new generation of Meteosat instruments.
The Imaging satellites embark two main instruments: the FCI (Flexible Combine Imager, successor of the MSG instrument, it will offer 16 channels between 0.3 and 13.3 microns, and deliver a full image of Earth every 10 minutes.) developed by Thales Alenia Space and the LI (Lightning Imager) manufactured by LEONARDO, whose objective is the early detection of severe storms as they develop. The MTG-S satellites carry an Infrared Sounder and the Copernicus Sentinel-4 instrument. The two MTG satellites are mounted on a common Platform developed by OHB.
Thales Alenia Space leads the industrial consortium that is building the MTG family, with OHB as major partner.
The launch has been followed by a LEOP (Launch and Early Orbit Phases) period of 15 days led by EUMETSAT and TELESPAZIO from Fucino in Italy. EUMETSAT and Telespazio was helped by a ESA/TAS/OHB project support team. The handover to EUMETSAT has been achieved in the last days of 2022 after the spacecraft has successfully reached its final position on geostationary orbit and has triggered the mode NOM/FPM (Fine Pointing Mode, very accurate Earth Pointing mode used to performed the observation). The satellite is now ready to undergo an eight months of commissioning activities whose objective will be to assess the satellite and instruments functionality, operability and performance against the space segment requirements. It will include the payloads activation and operability using the Instrument Quality Tool(IQT).
This paper presents the AOCS MTG design and the way it has behaved during the LEOP phase, including some lessons learnt for the next FMs. Then it introduces the first main results of the commissioning phase, notably the FPM mode performances after instrument activation (pointing and attitude estimation with STR merging software, RW friction compensation, FCI scan pointing and compensation of instrument disturbance by PF, on-board orbit propagator… ).
SELECTING KEY FEATURES OF 3D OBJECT MODEL FOR RELATIVE POSE ESTIMATION
Authors:   DLR, Wessling, Germany, Klionovska Ksenia , Burri Matthias 
Published: January 2024

The problem which is addressed in this paper refers to the discussion, how complex should be the
features extracted from the 3D mesh of a target, in order to get a stable and accurate relative pose estimation with monocular cameras during an On-Orbit Servicing (OOS) mission scenario.The process
of the key points extraction from 3D models is very challenging task because of following issues.
A) There is no strict definition how the interesting key features should be defined. In most cases it is
dependent on the features, which are going to be detected on the space object. Very common features
are corners or lines of the spacecraft, which can be detected from the visual data for further matching.
Considering these parts, we have to build a 3D key features of the target accordingly.
B) The up-to-date target model may be only available during the mission, e.g. reconstruction during
inspection phase. When we are still on the ground, we can only have an approximate 3D model of the
target. Then the question arises – how do we define the model key points on the ground before the
OOS mission takes place, if these points could be no more exist on the real space object? It should be
defined - if an on-board algorithm is needed or the data should be processed on the ground.
C) The limited computing power on board. The processing time for the model key extraction on
the ground is not a problem. The challenge is feature processing tasks in space using an On-Board
Computer (OBC). Dependent on the platform of OBC, the extraction of 2D image points with it
following matching should be fast enough to process live images.
We propose two models: the first model contains manually extracted key points; the second one has
key points extracted using HarrisKeypoint3D technique from PCL Library. The automatic process of
extracting 3D key points with HarrisKeypoint3D function can be used with different 3D meshes of
the space object. Thus, can be applied in different OOS missions. We are going to present the results
of relative pose estimation using two different models of the target mockup located at European Proximity Operations Simulator (EPOS), German Aerospace Center. Some camera images and ground
truth are collected for pose estimation tests also from EPOS facility.
Preferensi Konsumen Terhadap Penggunaan Aplikasi E-Wallet OVO (Studi Kasus Pada Generasi Z Bengkulu)
Authors: Shofura Afifah Salsabila , Rahmayanti Dewi 
Published: January 2024

Implementasi financial technology (fintech) di Indonesia akan terus meningkat seiring dengan kemajuan teknologi yang semakin berkembang pesat. Riset ini bermaksud melihat seberapa besar preferensi konsumen terhadap penggunaan aplikasi e-wallet OVO berdasarkan Model UTAUT 1. Populasi pada riset ini ialah Generasi Z dengan jumlah sampel yakni 209 responden. Data riset dikumpulkan dengan menyebarkan kuesioner yang dinilai dengan Skala Likert. Metode riset yang diterapkan ialah kuantitatif, dengan analisis data dilaksanaka SEM (Structural Equation Modeling) pada aplikasi SmartPLS 4.0.9.7. Temuan riset memperlihatkan variabel ekspektasi usaha, pengaruh sosial, kondisi yang memfasilitasi serta use behavior berkorelasi signifikan. Namun, pada variabel ekspektasi kerja dan behavior intention tidak terdapat pengaruh yang signifikan terhadap preferensi konsumen terhadap penerapan aplikasi e-wallet OVO. Hasil pengaruh secara simultan dari keseluruhan variabel adalah 79,6%. Saran dari penelitian ini untuk menambah variabel yang relevan dan sampel yang beragam dari berbagai kalangan.
Pengaruh Kepercayaan Terhadap Loyalitas Nasabah Pada KSPPS BMT Usaha Bersama (UB) Amanah Syariah Lau Dendang
Authors: Dewi Nanda Kusuma 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui apakah kepercayaan mempengaruhi loyalitas nasabah pada KSPPS BMT Usaha Bersama (UB) Amanah Syariah Lau Dendang. Penelitian ini menggunakan metode penelitian kuantitatif. Populasi dalam penelitian ini adalah nasabah KSPPS BMT Usaha Bersama Amanah Syariah Lau Dendang pada tahun 2022. Sampel dalam penelitian ini adalah sebanyak 92 nasabah. Teknik pengumpulan data dalam penelitian ini adalah observasi dan angket dengan menggunakan pengukuran skala likert. Teknik analisis data yang digunakan adalah uji validitas, uji reabilitas, uji normalitas, uji regresi linear sederhana dan uji hipotesis dengan program SPSS. Hasil penelitian menunjukkan bahwa terdapat pengaruh positif antara variabel kepercayaan terhadap loyalitas nasabah.
Factores que influyen en la supervivencia de pacientes con diálisis en El Salvador
Authors: Rivera Rosales David Daniel , Tejada Peña David Alexander 
Published: January 2024

Introducción. La enfermedad renal crónica es responsable de aproximadamente 2,4 millones de defunciones a nivel mundial. La supervivencia a los cinco años después de iniciar diálisis se encuentra entre un 39 a 60 % dependiendo del país. Objetivo. Describir la situación epidemiológica de los pacientes con diálisis y analizar los factores que influyen en la supervivencia de pacientes a cinco años de iniciar tratamiento sustitutivo renal en El Salvador. Metodología. Estudio de cohorte retrospectiva de los pacientes incluidos en el Registro Nacional de Diálisis y Trasplante Renal desde enero de 2016 hasta febrero de 2023. El seguimiento se comenzó al inicio de la diálisis, el evento de interés fue la muerte del paciente. Se utilizó el método de Kaplan-Meier para determinar la supervivencia al año y a los cinco años y la regresión de Cox con el modelo de Royston-Parmar para analizar los factores que influyen sobre la supervivencia a los cinco años. Resultados. El estudio incluyó 7088 pacientes, la supervivencia a uno y cinco años fue del 79,5 % (IC 95 %: 78,6-80,5) y 50,6 % (IC 95 %: 49,1-52,1) respectivamente. La regresión de Cox para la edad de inicio de tratamiento resultó en un hazard ratio de 1,02 (IC 95 %: 1,01-1,02), mientras que para el oficio de ser agricultor el hazard ratio fue 1,1 (IC 95 %: 1,01-1,18) y para la etiología hipertensiva el hazard ratio fue de 0,7 (IC 95 %: 0,64-0,78). Conclusión. La edad de inicio de tratamiento y el ser agricultor están asociados con una menor supervivencia a cinco años en pacientes con diálisis.
Seroprevalencia de Toxoplasma gondii y su relación con trastornos mentales en adultos
Authors: Lemus Buitrago Luis Felipe , Osegueda Ascencio Diego José , Fuentes Rodríguez Verónica Cecilia 
Published: January 2024

El Toxoplasma gondii es un parásito que se encuentra, aproximadamente, en el 30 % de la población humana. Durante los últimos años se ha evidenciado que la infección latente puede ser un factor de riesgo para el desarrollo de trastornos mentales; particularmente para la esquizofrenia, ansiedad, trastornos bipolares y trastornos de conducta. La asociación con los trastornos neuropsiquiátricos pueden explicarse por la influencia que tiene el parásito sobre la expresión de múltiples neurotransmisores; entre ellos la dopamina. Se realizó una búsqueda en las bases de datos PubMed y SciELO de 2015 a 2023, se seleccionaron artículos originales y de revisión de revistas científicas internacionales, en idiomas inglés y español con el objetivo de describir la relación entre la seroprevalencia de T. gondii y el desarrollo de trastornos mentales en población adulta. Existe relación entre los trastornos mentales en la población adulta con la infección por Toxoplasma gondii y este aumenta la posibilidad de desarrollar esquizofrenia y depresión en individuos sin historial previo, y que podría exacerbar cuadros psiquiátricos previos con dificultad en el tratamiento. Sin embargo, no todos los datos estadísticos establecen una relación directa, algunos estudios demuestran una asociación, ciertos datos son discordantes, lo que abre una puerta para futuras investigaciones.
Alteraciones genéticas asociadas a enfermedad de Parkinson y Alzheimer: evolución y respuesta al tratamiento
Authors: Quezada Rivera Rodrigo Antonio , Bonilla Rodríguez Francisco Esteban , Benavides Romero Marcela Alejandra , Peña Martínez Susana Lissette 
Published: January 2024

La enfermedad de Parkinson y Alzheimer son las enfermedades neurodegenerativas más frecuentes a nivel mundial. Tienen etiología multifactorial, entre ellas, la genética; y son motivo de interés en la investigación científica actual. Se realizó una revisión narrativa con el objetivo de determinar las alteraciones genéticas asociadas a estas patologías, además su influencia en la evolución y respuesta al tratamiento de ellas. Se consultaron artículos originales, revisiones bibliográficas, sistemáticas, metaanálisis en inglés y español, con fecha de publicación entre el 1 enero de 2018 y el 20 de mayo de 2023, en bases como PubMed y Medline. Se utilizaron los términos MeSH «Alzheimer Disease», «Parkinson Disease», «Drug Therapy» y «Mutations». El riesgo hereditario para la enfermedad de Parkinson suele ser poligenético, sin embargo, existen genes relacionados con mutaciones monogénicas. Se identifican alteraciones en genes de α-sinucleína, glucocerebrosidasa y quinasa 2 rica en leucina que se relacionan con mayor riesgo de desarrollar Parkinson, además de variaciones en el cuadro clínico y edad de inicio de síntomas. En cuanto a la enfermedad de Alzheimer, las alteraciones en los genes de la proteína precursora amiloide, presenilina 1 y 2 se relacionan con la forma familiar de la enfermedad; por otra parte, las de apolipoproteína E4 se han identificado en la forma esporádica, por lo que se consideran como el factor de riesgo genético más importante para su desarrollo.
Analysis of the development of China's fresh agricultural products e-commerce platform based on Marx's production and circulation theory
Authors: Yang Jinghan 
Published: January 2024

The key problem of agricultural production is to realize the value of agricultural products. At present, the actual circulation of agricultural products in China is restricted by various problems. In response to the question of how to better smooth the circulation system of agricultural products in the context of the normalized management of the epidemic and the digital economy, Chinese academics are currently more inclined to use economic principles to study and answer it. This paper uses an indirect research method, combined with the theory of production and circulation in Marxist political economy, to try to analyze the development direction of China's agricultural products circulation system under digital inclusion. The critical factor for advancing the transformation and upgrading of China's agricultural goods circulation system is in the reduction of circulation time and costs, hence enhancing the efficiency of agricultural product circulation. Hence, it is imperative to proactively cultivate novel rural e-commerce models alongside enhancing the conventional agricultural product circulation system. This entails encouraging diverse stakeholders to actively engage in the establishment of a contemporary agricultural product circulation system under government guidance, while also enhancing the organization and digitization of agricultural product distribution.