bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia Attenuates Pressure Overload‐Induced Heart Failure
Authors: Froese Natali , Szaroszyk Malgorzata , Galuppo Paolo , Visker Joseph R. , Werlein Christopher , Korf‐Klingebiel Mortimer , Berliner Dominik , Reboll Marc R. , Hamouche Rana , Gegel Simona , Wang Yong , Hofmann Winfried , Tang Ming , Geffers Robert , Wende Adam R. , Kühnel Mark P. , Jonigk Danny D. , Hansmann Georg , Wollert Kai C. , Abel E. Dale , Drakos Stavros G. , Bauersachs Johann , Riehle Christian 
Published: January 2024

Background
Alveolar hypoxia is protective in the context of cardiovascular and ischemic heart disease; however, the underlying mechanisms are incompletely understood. The present study sought to test the hypothesis that hypoxia is cardioprotective in left ventricular pressure overload (LVPO)–induced heart failure. We furthermore aimed to test that overlapping mechanisms promote cardiac recovery in heart failure patients following left ventricular assist device‐mediated mechanical unloading and circulatory support.

Methods and Results

We established a novel murine model of combined chronic alveolar hypoxia and LVPO following transverse aortic constriction (HxTAC). The HxTAC model is resistant to cardiac hypertrophy and the development of heart failure. The cardioprotective mechanisms identified in our HxTAC model include increased activation of HIF (hypoxia‐inducible factor)‐1α–mediated angiogenesis, attenuated induction of genes associated with pathological remodeling, and preserved metabolic gene expression as identified by RNA sequencing. Furthermore, LVPO decreased
Tbx5
and increased
Hsd11b1
mRNA expression under normoxic conditions, which was attenuated under hypoxic conditions and may induce additional hypoxia‐mediated cardioprotective effects. Analysis of samples from patients with advanced heart failure that demonstrated left ventricular assist device–mediated myocardial recovery revealed a similar expression pattern for
TBX5
and
HSD11B1
as observed in HxTAC hearts.

Conclusions
Hypoxia attenuates LVPO‐induced heart failure. Cardioprotective pathways identified in the HxTAC model might also contribute to cardiac recovery following left ventricular assist device support. These data highlight the potential of our novel HxTAC model to identify hypoxia‐mediated cardioprotective mechanisms and therapeutic targets that attenuate LVPO‐induced heart failure and mediate cardiac recovery following mechanical circulatory support.
The Story of Adoram the Taskmaster over the Forced Labor and the Traditions Regarding the Kingdom’s Division
Authors: Darshan Guy 
Published: January 2024

Abstract
This study compares the three major versions of the concluding verses of the story of the assembly at Shechem (1 Kgs 12:13–20): the Masoretic Text (MT), its Septuagint counterpart (G*), and the version found in 3 Kgdms 12:24s–u LXX called the “Alternative Story” (AS). While the MT version includes an account concerning Adoram the taskmaster over the forced labor (12:18a, 19), the shorter AS lacks this detail. This fact, together with additional historical and philological considerations, serves as the basis for the article’s proposal that the brief report on Adoram originated from an independent account that provides a unique and distinct explanation for the Kingdom’s division. This tradition diverges from, yet exhibits certain similarities to other explanations for the schism, as described in the Shechem assembly story, the account of Jeroboam’s rise, and the Deuteronomistic editorial strata.
‘A Jurisprudence for the Future’: Anticolonial Lawyering during the Vietnam War Years
Authors: Kiechel Charlotte 
Published: January 2024

Abstract
This article explores the dilemmas of progressive legalism during the Vietnam War years (1965–1975) by investigating the history of the Russell Tribunal. Scholars have argued that the 1960s witnessed a flourishing of anticolonial legalism, as activists sought to purge international law of its imperial origins. However, as the history of the Russell Tribunal shows, the transformation of law from a handmaiden of empire into a tool of anti-imperial resistance was not straightforward. This article examines the strategies employed by activists to overcome international law’s imperial biases. It argues that activists focused on developing a ‘jurisprudence for the future’, a mode of activism aimed at constructing international rules and norms that challenged, rather than sustained, European domination. By advocating for a future-oriented activism, tribunal members sought a temporary solution to the predicament of law’s imperial leanings. They defended their use of international law by asserting that their protests would contribute to the emergence of a future and more emancipatory international law. Nevertheless, an examination of the World Tribunal on Iraq (2003–2005) reveals that this envisioned future international law has yet to materialize. This article highlights the significance of futurism in the history of anticolonial lawyering and suggests that scholars should evaluate the limitations of a future-oriented legal activism.
Taking Stock of the Scholarship on the Relationship between International Investment Law and the Need for Raised Climate Ambition
Authors: Hall Jenny , Koen Louis 
Published: January 2024

Abstract
Increasingly dire warnings about the climate crisis mean that it is more urgent than ever that different legal regimes, including international investment law, are aligned with climate objectives and not implemented in discord with climate solutions. Many works have been produced over the last twenty years which examine whether the norms underlying climate law and international investment law necessarily conflict or can be reconciled. These works reflect deeply contested views amongst scholars as to whether regulation aimed at ensuring climate ambition can, or is likely to, be adequately safeguarded by the international investment law regime that is designed to provide conditions of stability for investors – including those that are large greenhouse gas emitters. This article provides an overview of the different perspectives that have been offered on the relationship between climate change law and international investment law in respect of three role-players – namely, arbitrators, civil society, and states. It concludes by offering tentative thoughts on the course that the interaction between the two regimes may take in the future.
Effects of Payment for Ecosystem Services and Tourism on Conservation and Development: Trade-Off or Synergistic?
Authors: Wang Yujun , Yang Hongbo , Hull Vanessa , Zhang Jindong , Chen Xiaodong , Li Xiang , Zhang Zejun , Li Cheng , Wang Fang , Zhao Zhiqiang , Tang Ying , Liu Jianguo 
Published: January 2024

Abstract
The effects of various strategies aimed at simultaneously promoting environmental conservation and human development are closely related to sustainable development regionally and globally. However, although the effects of many such strategies have been evaluated by ecologists and sociologists separately, their ability to simultaneously meet these two anticipated goals (i.e., environmental conservation and human development) at the fine spatial scale remains unclear. To answer this fundamental but crucial question, incorporating household and forest change data, we concurrently estimated the ecological and socioeconomic effects of two world-renowned Payment for Ecosystem Services (PES) programs (i.e., the Nature Forest Conservation Program, the Grain to Green Program) and nature-based tourism in 30 protected areas across 8 provinces in China. Here we showed a trade-off between the ecological and economic effects of two PES programs, while synergistic effects exist in the ecological and economic benefits of tourism. Attributes of household and protected areas significantly influenced economic and environmental benefits as well. Our research provides new insights into the complex effects of PES programs and tourism, and crucial information to support their adequate and sustainable implementation in China and the rest of the world.

Significance Statement
This work answers a fundamental but crucial question, that is, whether the policies commonly advocated to incorporate environmental conservation and human development can yield positive effects both for conservation and economic development. Our evaluation is also timely to inform some shortness (i.e., negligible economic effects, or the lack of expected positive economic benefits) and provides new insights (e.g., the implication of households and protected-areas attributes in conservation and economic outcomes) of Payment for Ecosystem Services (PES) programs and the complex effects of instruments in the context of multiple policies, particularly given the upcoming 2030 deadline for achieving the Sustainable Development goals (SDGs). We expected that implications in this study can provide important lessons for these two instruments, other PES programs, and other conservation and development instruments to support their adequate and sustainable implementation in China and beyond and to contribute to the achievement of relevant SDGs in the remaining years.
Popliteal artery aneurysm repair—A single center experience
Authors: Demas Nicholas , Saha Sibu P 
Published: January 2024

Background Popliteal artery aneurysms (PAAs) are relatively rare but are one of the most common peripheral arterial aneurysms. Open popliteal artery aneurysm repair (OPAR) has been the standard, but technological advancements have made endovascular popliteal artery aneurysm repair (EPAR) a promising alternative. The aim of this study is to compare EPAR and OPAR efficacy and outcomes over a 10-year period. Methods This study retrospectively reviewed 72 patient charts who were diagnosed with PAA or popliteal artery pseudoaneurysm and underwent EPAR or OPAR from 1 January 2010 to 31 December 2019. Endovascular popliteal artery aneurysm repair was used in 37 cases and OPAR in 35 cases. Results Graft patency <30 days postoperative was 100% in both EPAR and OPAR groups. Graft patency >90 days postoperative was 72.73% in the EPAR group and 82.35% in the OPAR group ( p = 0.477). Graft patency >2 years postoperative was 81.25% in the EPAR group and 86.67% in the OPAR group ( p = 0.682). Freedom from reoperation 30-day postoperative was 78.38% in the EPAR group and 80% in the OPAR group ( p = 0.865). Freedom from amputation 30-day postoperative was 91.43% in the EPAR group and 94.29% in the OPAR group ( p = 0.263). The 30-day survival rate was 94.59% in the EPAR group and 100% in the OPAR group. Conclusions Endovascular repair represents a promising alternative for PAA repair. Our results demonstrate that EPAR has similar outcomes for asymptomatic, acutely symptomatic, and chronic symptomatic patients. Technological advancements of stent properties and refinement of surgical techniques may further improve endovascular techniques.
Influence of Lifestyle Factors on Metabolic Syndrome in Psychiatric Patients Attending a Community Mental Health Setting: A Cross-sectional Study
Authors: Kar Nilamadhab , Barreto Socorro 
Published: January 2024

Background: Metabolic syndrome (MetS) is a concern in psychiatric patients. We aimed to study the influence of the modifiable lifestyle factors on MetS in adult psychiatric patients along with associated clinical factors and quality of life. Methods: Factors such as diet (Healthy Eating Index), exercise, substance use, cardiovascular risk (QRISK), illness severity (Clinical Global Impression), medications, adverse events (Systematic Monitoring of Adverse Events Related to Treatments), and quality of life (Recovering Quality of Life Scale) were assessed along with clinical components for MetS in 323 psychiatric patients receiving routine care and monitoring in a Community Mental Health Team. Results: MetS was present in 50.5% (95% CI: 45.0–55.9). It was significantly associated with higher age, duration of mental illness, body mass index (BMI), QTc, QRISK, and antipsychotic drugs. In logistic regression, age, QTc, QRISK, and BMI remained significantly linked to MetS. Patients with or without MetS were comparable in their lifestyle factors such as diet, exercise, and substance use, along with the family history of metabolic disorders, age at onset of mental illness, duration of antipsychotic medication, side effects, psychiatric diagnoses, and quality of life. However, many patients with or without MetS had poorer diet and physical inactivity, indicating scope for interventions. Conclusions: Around half of the psychiatric patients had MetS, and modifiable lifestyle factors did not differentiate individuals with or without MetS. The need for further research on the prevention and management of MetS in psychiatric patients is highlighted.
Does Including Facebook Training Improve the Effectiveness of Computerized Cognitive Training? A Randomized Controlled Trial
Authors: Rute-Pérez S , Rodríguez-Domínguez C , Sánchez-Lara EM , Pérez-García M , Caracuel A 
Published: January 2024

Objective To determine whether implementing a Facebook training program improves the effectiveness of computerized cognitive training (CCT) in older adults. Design Randomized, controlled, double single-blind trial with parallel groups. Setting Community centers. Subjects Eighty-six adults between 60 and 90 years old. Interventions Nine face-to-face 60-min sessions of CCT with VIRTRAEL for all participants. The experimental group received an additional 30 min of Facebook training per session. Main measures Attention (d2 Test of Attention); learning and verbal memory (Hopkins Verbal Learning Test-Revised); working memory (Letter-Number Sequencing test), semantic and abstract reasoning (Similarities and Matrix Reasoning tests); and planning (Key Search test). Results There was a significant Group*Time interaction in the Hopkins Verbal Learning Test-Revised-Trial 3, Letter-Number sequencing, and Matrix tests. Between groups, post-hoc analyses showed a difference in Matrix reasoning ( p < .001; d  =  0.893) at post-intervention in favor of the experimental group. Significant main effects of time were found in the CCT group between baseline and 3-month follow-up for Concentration (F  =  26.431, p ≤ .001), Letters and Numbers (F  =  30.549, p ≤ .001), Learning (F  =  38.678, p ≤ .001), Similarities (F  =  69.885, p ≤ .001), Matrix (F  =  90.342, p ≤ .001), and Key Search (F  =  7.904, p  =  .006) tests. Conclusions The utilization of CCT with VIRTRAEL, a freely accessible tool with broad applicability, resulted in enhanced attention, verbal learning, working memory, abstract and semantic reasoning, and planning among older adults. These improvements were sustained for at least three months post-training. Additional training in Facebook did not enhance the effectiveness of CCT.
Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study
Authors: Barbut Siva Jessica , Barba Tommaso , Kettner Hannes , Kuc Joanna , Nutt David J , Carhart-Harris Robin , Erritzoe David 
Published: January 2024

Background: There is growing evidence for the therapeutic effects of psychedelics. However, it is still uncertain how these drugs interact with serotonergic antidepressants (serotonin reuptake inhibitors (SRIs)). Objective: This study explores the interaction between psychedelics and SRIs in terms of therapeutic effects. The objective is to compare acute psychedelic effects and subsequent changes in well-being and depressive symptoms among ‘SRI −’ individuals (not on psychiatric medication) and ‘SRI +’ individuals (undergoing SRI treatment). Methods: Using prospective survey data, the study employs multivariate analysis of covariance (MANCOVA) and linear mixed effect models to analyse subjective differences and changes in well-being and depressive symptoms pre- and post-psychedelic experiences. Results: Results indicate that ‘SRI −’ participants experience significantly more intense subjective effects compared to ‘SRI +’ participants ( F = 3.200, p = 0.016) in MANCOVA analysis. Further analysis reveals ‘SRI –’ individuals report stronger mystical (18.2% higher, p = 0.048), challenging (50.9% higher, p = 0.001) and emotional breakthrough experiences (31.9% higher, p = 0.02) than ‘SRI +’ individuals. No differences are observed in drug-induced visual effects ( p = 0.19). Both groups exhibited similar improvements in well-being and depressive symptoms after the psychedelic experience. Conclusion: Individuals presumed to be on serotonergic antidepressants during psychedelic use display reduced subjective effects but similar antidepressant effects compared to those not undergoing SRI treatment. Further controlled research is needed to comprehend the interplay between serotonergic antidepressants and psychedelics, illuminating potential therapeutic benefits and limitations in clinical contexts.
Pembrolizumab-induced agranulocytosis
Authors: Fernández Martínez Víctor , García-Avello Fernández-Cueto Adela , Valencia Soto Carmen María , Barbadillo Villanueva Sara , Ochagavía Sufrategui María , Rioja Carrera María , Alonso Buznego Lucía Andrea , Valero Domínguez Marta 
Published: January 2024

Introduction With the widespread use of anti-programmed death-1 monoclonal antibodies, such as pembrolizumab, rare side effects appear in clinical practice. Case report We report the case of a man diagnosed with non-keratinizing squamous lung carcinoma stage IVB with programmed death-ligand 1 70% who developed agranulocytosis 10 days after a single dose of pembrolizumab as monotherapy. Management and outcome Pembrolizumab was discontinued immediately. Grade 4 neutrophil decrease is mentioned in the product information sheet as a rare side effect. The patient was admitted in poor physical condition with grade 4 neutropenic fever, mucositis and anemia. Agranulocytosis did not improve despite treatment with granulocyte colony-stimulating factor, intravenous corticosteroids and intravenous immunoglobulins. He experienced a rapid worsening and died 3 weeks after admission. The causal relationship between pembrolizumab and the appearance of agranulocytosis was determined as possible according to Naranjo's modified Karch and Lasagna's imputability algorithm. Discussion Hematologic immune-related adverse events are uncommon but important side effects among patients treated with immune checkpoint inhibitors. Agranulocytosis and neutropenia are infrequently reported but can be life-threatening. The main approach for agranulocytosis consists of intravenous corticosteroids, granulocyte colony-stimulating factors and blood products. Depending on bone marrow characteristics, treatments for refractory patients include intravenous immunoglobulins or cyclosporine. After an immune-related adverse event, benefits and risks must be considered before continuation with an immune checkpoint inhibitor. Detection and communication of adverse drug reactions to the Pharmacovigilance Systems have special relevance for rare side effects.
A Qualitative Analysis of Perspectives on Self-directed Violence in a Prospective Longitudinal Study of Young Women With and Without Childhood ADHD
Authors: Ahmad Shaikh I. , Hinshaw Stephen P. 
Published: January 2024

Objective: Non-suicidal self-directed violence (NSSDV) is a significant and growing youth public health crisis. Girls with ADHD are at increased risk of engaging in NSSDV, yet qualitative studies with this population—to better understand manifestations, motivations, and developmental course—are lacking. Method: We conducted semi-structured, qualitative interviews with a sub-sample of 57 young women (32 with childhood ADHD, 25 neurotypical comparisons; mean age of 27 years, part of a larger prospective longitudinal study) regarding histories and manifestations of NSSDV. Results: Inductive and deductive analysis revealed several key themes, including self-perceived reasons for engaging in NSSDV (affect regulation, attention seeking, self-punishment, asserting control), impulsivity, secretiveness, and in some cases motivations for desistance. Conclusion: Findings underscore the importance of early education and screening, especially among high-risk clinical populations. Increased resources and supports for professionals, parents, and peers are indicated, along with countering the persistent stigma associated with ADHD and NSSDV.
Lifestyle factors associated with age-related macular degeneration: Case-control study
Authors: Kráľová Jana Šalková , Kolář Petr , Kapounová Zlata , Veselý Petr , Brázdová Zuzana Derflerová 
Published: January 2024

Background Age-related macular degeneration (AMD) is one of the major causes of vision loss in individuals aged ≥ 65 years in developed countries. This study aimed to determine the associations between modifiable risk factors and AMD. This is the first study describing the relationship between lifestyle factors and AMD in the Czech Republic. Methods In this cross-sectional case-control study, 93 AMD cases and 58 controls without AMD and cataract were included. All participants were examined by Optical coherence tomography at the Clinic of Eye Treatment at the University Hospital Brno. Data were collected using a pre-tested self-report questionnaire in a face-to-face interview. Results We found significant associations between those who were living in the city (OR 95% CI: 2.19 (1.0–4.6); p = 0,039), with a positive family history of AMD (OR 95% CI: 12.75 (1.6–98.6); p = 0,015), exposure to cigarette smoke (OR 95% CI: 2.72 (1.4–5.4); p = 0,004), and daily exposure to passive smoking (OR 95% CI: 2.29 (1.0–5.1); p = 0,045) and AMD. In men, we found significant associations between daily sunlight exposure (OR 95% CI: 2.98 (1.0–8.5); p = 0,041), short or long sleep duration (OR 95% CI: 3.98 (1.2–13.2); p = 0,024) and AMD. Men daily exposed to sunlight were at a 2.98 times higher risk of AMD than men with less than daily sunlight exposure. Men with short or long sleep duration (< 6 and > 8 h) were at a 3.98 times higher risk of AMD than men with recommended sleep duration of 6–8 h. Conclusions An increased risk of AMD was observed for living in the city, family history of AMD, exposure to cigarette smoke, and daily exposure to passive smoking. Increased risk of AMD was observed for daily sunlight exposure and short or long sleep duration; however, only in men.
Screening and Validation of Key Genes of Autophagy in Acute Myocardial Infarction Based on Bioinformatics
Authors: Geng Yingjie , Han Yu’e , Wang Shujuan , Qi Jia , Bi Xiaoli 
Published: January 2024

Aims: Autophagy plays a significant role in the development of acute myocardial infarction (AMI), and cardiomyocyte autophagy is of major importance in maintaining cardiac function. We aimed to identify key genes associated with autophagy in AMI through bioinformatics analysis and verify them through clinical validation. Materials and Methods: We downloaded an AMI expression profile dataset GSE166780 from Gene Expression Omnibus (GEO). Autophagy-associated genes potentially differentially expressed in AMI were screened using R software. Then, to identify key autophagy-related genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI) analysis, Receiver Operating Characteristic (ROC) curve analysis, and correlation analysis were performed on the differentially expressed autophagy-related genes in AMI. Finally, we used quantificational real-time polymerase chain reaction (qRT-PCR) to verify the RNA expression of the screened key genes. Results: TSC2, HSPA8, and HIF1A were screened out as key autophagy-related genes. qRT-PCR results showed that the expression levels of HSPA8 and TSC2 in AMI blood samples were lower, while the expression level of HIF1A was higher than that in the healthy controls. Conclusions: TSC2, HSPA8, and HIF1A were identified as key autophagy-related genes in this study. They may influence the development of AMI through autophagy. These findings may help deepen our understanding of AMI and may be useful for the treatment of AMI.