bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Molecular and Precision Medicine Clinic to Improve Access to Clinical Trials for Patients With Metastatic Breast Cancer: An Academic/Community Collaboration
Authors: Spring Laura M. , Mortensen Lindsey , Abraham Elizabeth , Keenan Jennifer , Medford Arielle , Ma Annie , Padden Sarah , Denault Elyssa , Ryan Lianne , Iafrate A. John , Lennerz Jochen , Hochberg Ephraim , Wander Seth A. , Moy Beverly , Isakoff Steven J. , Juric Dejan , Brennan Kimberly A. , Smith Deborah E. , Civiello Barbara , Mulvey Therese , Comander Amy , Ellisen Leif W. , Schwartz Joel H. , Bardia Aditya 
Published: November 2023

PURPOSE There is a demand for improved care delivery surrounding genomic testing and clinical trial enrollment among patients with metastatic breast cancer (MBC). We sought to improve the current process via real-time informal consultation and prescreening assessment for patients with MBC treated by community and academic medical oncologists by implementing a virtual molecular and precision medicine (vMAP) clinic. METHODS The vMAP program used a virtual referral system directed to a multidisciplinary team with precision medicine expertise. Providers contacted vMAP regarding patients with MBC, and on receipt of referral, the vMAP team engaged in discussion to identify if further diagnostics were needed (including genomic testing) and to identify potential clinical trials or standard treatment options. Recommendations were then sent to the referring provider within 72 hours. Pre-/postsurveys were issued to network physicians to assess for barriers, clinical trial access, and vMAP referral experience. Program implementation was evaluated with the Squire 2.0 reporting guidelines for quality improvement in health care as a framework. RESULTS Eighty-one cases from 22 providers were referred to vMAP over a 26-month period. The average response time to the referring provider with a finalized recommendation was 1.90 ± 1.82 days. A total of 86.4% of cases had clinical trial options on vMAP prescreen, with 40.7% initiating formal screening assessments and 27 patients (33.3%) ultimately enrolling on trials. On resurvey, 92% of survey responses across community oncology referring providers said that they were very likely to use vMAP again. CONCLUSION In the initial 2-year period, vMAP demonstrated an efficient means to offer real-time interpretation of genomic testing and identification of clinical trials for patients with MBC, with effective clinical trial enrollment and high rates of referring provider satisfaction.
Postnatal clubs: Implementation of a differentiated and integrated model of care for mothers living with HIV and their HIV-exposed uninfected babies in Cape Town, South Africa
Authors: Nelson Aurelie , Lebelo Keitu , Cassidy Tali , Duran Laura Trivino , Mantangana Nompumelelo , Mdani Leticia , Malabi Nikiwe , Solomon Suhair , Buchanan Kate , Hacking Damian , Bhardwaj Vinayak , de Azevedo Virginia , Patel-Abrahams Shariefa , Harley Beth , Hofmeyr Clare , Schmitz Kathrin , Myer Landon 
Published: November 2023

Background
Despite the overall reduction in the HIV mother-to-child transmission (MTCT) rate in South Africa, poor adherence and retention in care during breastfeeding contribute to this period being a major driver of MTCT in South Africa. To improve this retention, postnatal clubs were created as an integrated, differentiated model of care providing psychosocial support and comprehensive care for the mother-infant pairs (MIP), including HIV and under-5-child services. We describe the implementation of these facility-based clubs and examine its health outcomes in a peri-urban primary health care setting in Cape Town, South Africa.

Methods
In this prospective cohort study, conducted between June 2016 and December 2019, MIPs were recruited into postnatal clubs between 6 weeks and 6 months of age and followed-up until 18 months of age. Outcomes including maternal Viral Load (VL), and children’s HIV testing were compared to a historical control group. Children’s immunizations and maternal sexual and reproductive health outcomes are also described.

Results
During the implementation of the postnatal club study period, 484 MIP were recruited with 84% overall attendance, 95% overall viral load suppression, and 98% overall uptake of HIV infant testing. Compared to historical controls, the club infant rapid test uptake was 1.6 times higher (95% CI: 1.4–1.9) at 9 months and 2.0 times higher at 18 months (95% CI: 1.6–2.6). Through 12 months and between 12–18 months, maternal VL monitoring was higher in the club group compared to the historical control by 1.5 times (95% CI: 1.3–1.6) and 2.6 times (95% CI: 2.1–3.2), respectively, with similar maternal VL suppression. Of 105 infants attending the 12 months visit, 99% were fully vaccinated by one year.

Conclusion
MIP in the postnatal clubs showed better PMTCT outcomes than historical controls with high levels of retention in care. Other outcomes such as immunisation results suggest that integration of services, such as in the postnatal club, is feasible and beneficial for MIPs.
A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis
Authors: Alali Abdulla Mousa Falah , Padmaja Dhyaram Lakshmi , Soni Mukesh , Khan Muhammad Attique , Khan Faheem , Ofori Isaac 
Published: November 2023

Abstract
Lung cancer is a substantial health issue globally, and it is one of the main causes of mortality. Malignant mesothelioma (MM) is a common kind of lung cancer. The majority of patients with MM have no symptoms. In the diagnosis of any disease, etiology is crucial. MM risk factor detection procedures include positron emission tomography, magnetic resonance imaging, biopsies, X-rays, and blood tests, which are all necessary but costly and intrusive. Researchers primarily concentrated on the investigation of MM risk variables in the study. Mesothelioma symptoms were detected with the help of data from mesothelioma patients. The dataset, however, included both healthy and mesothelioma patients. Classification algorithms for MM illness diagnosis were carried out using computationally efficient data mining techniques. The support vector machine outperformed the multilayer perceptron ensembles (MLPE) neural network (NN) technique, yielding promising findings. With 99.87% classification accuracy achieved using 10-fold cross-validation over 5 runs, SVM is the best classification when contrasted to the MLPE NN, which achieves 99.56% classification accuracy. In addition, SPSS analysis is carried out for this study to collect pertinent and experimental data.
Modification effects of nanosilica on asphalt binders: A review
Authors: Dai Yiqing , Liang Wei , Ye Danwang , Xie Shengjia , Sang Yuan , Li Dong 
Published: November 2023

Abstract
Nanosilica (NS) may be obtained as a by-product in several industrial processes and is associated with high availability and affordability among other nanoadditives. NS has been used for asphalt modification, and improvement in high-temperature performance and several other physical properties has been reported. However, due to the wide varieties and intrinsic variability of asphalt materials, concerns have been raised about the reproducibility of some conclusions, and therefore, a review was conducted. According to the results, NS additives with a purity of over 99% were usually used for modification and the specific surface area was over 100 m2/g, leading to the superior absorption of asphalt and thus improvement in rutting resistance of the mixtures. Due to a lack of guidance for the blending procedures, inconsistency exists among studies in the shear speed, blending duration, and temperature, leading to possible excessive blending and unnecessary energy and time consumption. Rises in NS concentration would cause higher softening point and rotational viscosity, and therefore elevated temperatures for mixing and paving, but penetration would be reduced. According to rheological evaluations, with the rise of NS concentration, the rutting parameter would increase, indicating an improvement in the high-temperature performance, but the low-temperature performance may deteriorate.
Effect of polyvinyl alcohol fibers on mechanical properties of nano-SiO2-reinforced geopolymer composites under a complex environment
Authors: Zhang Peng , Wang Cong , Guo Zhenhui , Hong Jian , Wang Fei 
Published: November 2023

Abstract
Buildings in service are severely affected by the complex environment with multiple coupled factors such as high temperatures, humidity, and inorganic salt attack. In this work, the mechanical properties of nano-SiO2-reinforced geopolymer composites (NSGPC) incorporated with varying dosages of polyvinyl alcohol (PVA) fibers were investigated under a complex environment. A simulated environmental chamber was employed to simulate the complex environment with relative humidity, temperature, and NaCl solution concentration of 100%, 45°C, and 5%, respectively. Fly ash/metakaolin geopolymer composites (GPCs) were fabricated by utilizing 1.5% nano-SiO2 by weight and five various dosages of PVA fibers by volume (0, 0.2, 0.4, 0.6, and 0.8%). The compressive strength, tensile strength, elastic modulus, and impact resistance of NSGPC eroded in a simulated environmental chamber for 60 days were determined. Then, the impact of the PVA fiber dosage on the mechanical properties of NSGPC under complex coupled environments was analyzed. In addition, scanning electron microscopy (SEM) was employed to evaluate and analyze the microstructural behavior of NSGPC under complex environments. Results indicated that the compressive strength, tensile strength, elastic modulus, and impact resistance of NSGPC increased with increasing PVA fiber to 0.6% and then decreased with a continuous increase to 0.8% but remained higher than those of the reference specimen. NSGPC exhibited the best performance at a PVA fiber dosage of 0.6%, which increased by 13.3, 12.0, 17.2, and 522%, respectively. The outcomes of SEM analysis indicated that the usage of PVA fiber and NS remarkably improved the mechanical properties and microstructural behavior of GPC by making the inner structure of GPCs more robust and compact under a complex environment. The outcomes of this work can provide theoretical guidance for buildings serving under a complex environment.
The case of the missing entropy
Authors: Tolley H. Dennis , Woodfield Brian F. , Hansen Lee D. 
Published: November 2023

Abstract
The free expansion of an ideal gas into a vacuum is commonly used to illustrate a spontaneous process; however, what is often overlooked for this process is that there is no change in temperature (inherently isothermal), no exchange of heat into or out of the system (adiabatic), and no work done on or by the system. That is, for the expansion of an ideal gas into a vacuum, there are no changes in the energetic states of the particles in the system and, thus, no change in the energetic entropy, ΔS
E = 0. But, if ΔS
E = 0, then why is the process spontaneous? The answer is because the number of positional microstates increases. This paper describes the “missing entropy” originating from the distribution of particles in a system, as measured by ΔS
D. A positive ΔS
D is the only change associated with processes that are inherently isothermal, adiabatic, and include no external work. The entropy of the distribution of particles, S
D, was not included in Boltzmann’s distribution of energy in particles, S
E, which is used to explain the second law of thermodynamics. In Gibbs development of statistical thermodynamics, Gibbs included both particle distribution and energy distribution in his ensembles but only included energy distribution in deriving the macroscopic laws of thermodynamics. Consequently, thermodynamics cannot explain why spontaneous processes occur in inherently isothermal systems where heat and work are zero, (Q = W = 0) and ΔU = ΔS
E = 0. Examples of such processes include free expansion of an ideal gas, mixing of ideal gases, diffusion of an ideal solute, mixing of ideal solutes, osmosis with ideal solutions, and free discharge of a concentration battery with ideal solutions. This paper uses a combinatorial model of positional microstates to develop a statistical description of the entropy of the distribution of particles, S
D, and applies the model to calculate ΔS
D for these six examples of inherently isothermal processes in ideal systems. ΔS
D has implications for correctly understanding processes in systems that do no work on the surroundings, for understanding colligative properties, and for understanding biological evolution and other information-driven, inherently isothermal systems.
Axial compression behavior and stress–strain relationship of slurry-wrapping treatment recycled aggregate concrete-filled steel tube short columns
Authors: Wang Jinhao , Li Zhudan , Jin Baohong 
Published: November 2023

Abstract
The utilization of recycled concrete can effectively solve the problems of large accumulations of construction waste and the constant consumption of natural aggregates. Slurry-wrapping modification and concrete-filled steel tubes (CFSTs) are effective approaches to enhance the utilization ratio of recycled concrete. The study involved 4 ordinary CFST columns and 16 slurry-wrapping recycled aggregate concrete-filled steel tube (SRACFST) columns. The variable parameters included the slurry-wrapping recycled aggregate replacement ratio and the section form. The result shows that the ultimate strength of the specimens reached the minimum and maximum at 25 and 100% aggregate replacement ratio. The favorable strength performance of the SRACFST columns is attributed to the dominant positive effect of the slurry-wrapping treatment in reducing matrix porosity over the negative impact of the recycled aggregate’s complex interface transition zone. Due to the hoop factor, the residual bearing ratio peaks at a 25% substitution ratio. Four design standards were used to predict the ultimate strength, with GB50936 and EC4 yielding more accurate estimations, while AISC360-10 and AIJ provided conservative estimations. This study presents the equations of the stress–strain curve for the whole axial compression process, which can be directly applied in the theoretical and numerical analysis of RACFST columns.
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions
Authors: Ottoz Diana SM , Tang Lauren C , Dyatel Annie E , Jovanovic Marko , Berchowitz Luke E 
Published: November 2023

AbstractAmyloid‐like protein assemblies have been associated with toxic phenotypes because of their repetitive and stable structure. However, evidence that cells exploit these structures to control function and activity of some proteins in response to stimuli has questioned this paradigm. How amyloid‐like assembly can confer emergent functions and how cells couple assembly with environmental conditions remains unclear. Here, we study Rim4, an RNA‐binding protein that forms translation‐repressing assemblies during yeast meiosis. We demonstrate that in its assembled and repressive state, Rim4 binds RNA more efficiently than in its monomeric and idle state, revealing a causal connection between assembly and function. The Rim4‐binding site location within the transcript dictates whether the assemblies can repress translation, underscoring the importance of the architecture of this RNA‐protein structure for function. Rim4 assembly depends exclusively on its intrinsically disordered region and is prevented by the Ras/protein kinase A signaling pathway, which promotes growth and suppresses meiotic entry in yeast. Our results suggest a mechanism whereby cells couple a functional protein assembly with a stimulus to enforce a cell fate decision.
Contemporary social and political mega-crisis and the goals of economics
Authors: Kolodko Grzegorz W. 
Published: November 2023

AbstractContemporary economic thought does not deal suitably with the tasks it faces. Neither does it provide a satisfactory explanation of the socio-economic reality, nor does it propose effective methods of solving the mounting problems, especially at the macroeconomic level, in the national economy, and in the mega-economic level, in the world economy. The beyond-GDP reality requires a beyond-GDP economic theory on which a triple balanced – economically, socially and ecologically – beyond-GDP development strategy must be based. It is necessary to formulate anew the goal of economic activity, which cannot be a simple maximization of profit and a quantitative increase in production. The short-term interests of private capital should be subordinated to the long-term public interests, which is to be fostered by appropriate reinstitutionalization of the market economy. The economics has to be more oriented towards addressing the future challenges, and not mainly be inspired by conclusions drawn from observations of past events, which is often of little use in economic policy and development strategy. The new pragmatism is needed.
PENGARUH SIKAP PERCAYA DIRI DAN KEGIATAN PRAKTIK KERJA LAPANGAN TERHADAP KESIAPAN KERJA DI INDUSTRI PADA SISWA SEKOLAH MENENGAH KEJURUAN DI JAKARTA TIMUR
Authors: Doko Samuel 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh sikap percaya diri dan kegiatan praktik kerja lapangan terhadap kesiapan kerja di industri siswa kelas XI Program Keahlian Teknik Mekanik Otomotif di Sekolah Menengah Kejuruan di Jakarta Timur. Penelitian ini menggunakan desain expost facto dengan pendekatan kuantitatif kausal. Populasi dalam penelitian yaitu seluruh siswa kelas XI Program Keahlian Teknik Mekanik Otomotif di Sekolah Menengah Kejuruan di Jakarta Timur, yang berjumlah 200 siswa, dengan sampel 133 siswa diambel secara proportionate stratified random sampling. Metode pengumpulan data menggunakan metode angket. Analisis data diuji menggunakan teknik pengujian regresi ganda. Hasil dari penelitian ini menunjukkan bahwa sikap percaya diri siswa berpengaruh positif langsung terhadap kesiapan kerja di industry dengan nilai konstribusi sebesar 32%. Sedangkan kegiatan praktik kerja lapangan memiliki pengaruh langsung positif terhadap kesiapan kerja di industry dengan konstribusi sebesar 32%. Sikap percaya diri berpengaruh langsung positif terhadap kegiatan praktik kerja langan dnegan nilia konstribusi sebesar 24%. Sikap percaya diri memiliki pengaruh tidak langsung terhadap kesiapan kerja praktik melalui kegiatan parktik kerja lapangan dengan nilai konstribusi sebesar 47%.
Kata kunci: sikap percaya diri, praktik kerja lapangan, dan kesiapan kerja di industri
Younger Patients Undergoing Total Ankle Arthroplasty Experience Higher Complication Rates and Worse Functional Outcomes
Authors: Anastasio Albert T. , Kim Billy I. , Wixted Colleen M. , DeOrio James K. , Nunley James A. , Easley Mark E. , Adams Samuel B. 
Published: November 2023

Background:
Although many patients with posttraumatic ankle arthritis are of a younger age, studies evaluating the impact of age on outcomes of primary total ankle arthroplasty (TAA) have revealed heterogenous results. The purpose of the present study was to determine the effect of age on complication rates and patient-reported outcomes after TAA.

Methods:
We retrospectively reviewed the records of 1,115 patients who had undergone primary TAA. The patients were divided into 3 age cohorts: <55 years (n = 196), 55 to 70 years (n = 657), and >70 years (n = 262). Demographic characteristics, intraoperative variables, postoperative complications, and patient-reported outcome measures were compared among groups with use of univariable analyses. Competing-risk regression analysis with adjustment for patient and implant characteristics was performed to assess the risk of implant failure by age group. The mean duration of follow-up was 5.6 years.

Results:
Compared with the patients who were 55 to 70 years of age and >70 years of age, those who were <55 years of age had the highest rates of any reoperation (19.9%, 11.7%, and 6.5% for the <55, 55 to 70, and >70-year age groups, respectively; p < 0.001), implant failure (5.6%, 2.9%, and 1.1% for the <55, 55 to 70, and >70-year age groups, respectively; p = 0.019), and polyethylene exchange (7.7%, 4.3%, and 2.3% for the <55, 55 to 70, and >70-year age groups, respectively; p = 0.021). Competing-risk regression revealed a decreased risk of implant failure for patients who were >70 of age compared with those who were <55 years of age (hazard ratio [HR], 0.21 [95% confidence interval (CI), 0.05 to 0.80]; p = 0.023) and for patients who were 55 to 70 years of age compared with those who were <55 years of age (HR, 0.35 [95% CI, 0.16 to 0.77]; p = 0.009). For all subscales of the Foot and Ankle Outcome Score (FAOS) measure except activities of daily living, patients who were <55 years of age reported the lowest (worst) mean preoperative and postoperative scores compared with those who were 55 to 70 years of age and >70 years of age (p ≤ 0.001). Patients who were <55 years of age had the highest mean numerical pain score at the time of the latest follow-up (23.6, 14.4, 12.9 for the <55, 55 to 70, and >70-year age groups, respectively; p < 0.001).

Conclusions:
Studies involving large sample sizes with intermediate to long-term follow-up are critical to reveal age-related impacts on outcomes after TAA. In the present study, which we believe to be the largest single-institution series to date evaluating the effect of age on outcomes after TAA, younger patients had higher rates of complications and implant failure and fared worse on patient-reported outcome measures.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Multistage Strike-Slip Fault in the Narrowest Portion of the Qinling Orogen, Central China: Deformation Mechanism and Tectonic Significance
Authors: Zhang Yiping , Chen Xuanhua , Wang Yannan , Zuza Andrew V. , Zhang Jin , Li Bing , Wang Yongchao , Wang Ye , Liu Kui , Han Lele , Zhang Beihang , Zhao Heng 
Published: November 2023

Abstract
The North Huicheng Basin strike-slip fault system is on the northeastern frontier of the Tibetan Plateau and separates the West and East Qinling differential orogeny. However, the deformation mechanism of this strike-slip fault system and its exact tectonic significance are unclear. Here, we carried out systematic field structural analysis, physical analog modeling, and multiproxy geochronological dating to address these issues. The field structural analysis indicates that the North Huicheng Basin strike-slip fault system was induced from the plate-like movement of the West and East Qinling Orogens, which underwent multiple left-lateral strike-slip faulting and controlled salient and recessed structures. The scaled physical analog experiment results confirm this hypothesis and reveal the primary spatial-temporal deformational kinematic process. Combined with published works, multiproxy geochronological dating (zircon U‒Pb age of 213 Ma, biotite 40Ar/39Ar age of 203 Ma, and apatite fission-track age of 56 Ma) outlines the main thermal history of the hanging wall. Based on the above facts, the integrated research suggests that multistage strike-slip faulting played a significant role in the main tectonic events, that is, late Triassic magmatic emplacement, Jurassic/Cretaceous local pull-apart, and Cenozoic rapid exhumation driven by Tibetan Plateau growth.