bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of risk factors for post-operative recurrence after percutaneous endoscopic lumbar discectomy in patients with lumbar disc herniation: a meta-analysis
Authors: Jiang Lin , Xie Xin , He Rongfang , Da Jun 
Published: December 2023

Abstract
Background
This study aimed to systematically evaluate risk factors for post-operative recurrence after percutaneous endoscopic lumbar discectomy (PELD) in patients with lumbar disc herniation (LDH).

Methods
The eligible studies were retrieved from PubMed, Embase, and Web of Science databases. Quality assessment was performed. The effects of binary variables (sex, Modic change (MC), type 2 diabetes (T2DM), and smoking) on post-operative recurrence were evaluated as odds ratio (OR) and 95% confidence interval (CI). The effects of continuous variables (sagittal range of motion (SROM), body mass index (BMI), and age) were assessed as weighted mean difference (WMD) and 95% CI. Sensitivity analysis and publication bias were conducted to evaluate the reliability of pooled results.

Results
Eight studies were included, and their methodological quality was medium. MC (OR (95% CI) = 3.88 (2.24–6.74), P < 0.001), smoking (OR (95% CI) = 1.87 (1.45, 2.42), P < 0.001), T2DM (OR (95% CI) = 1.61 (1.12, 2.31), P = 0.010), SROM (WMD (95% CI) = 2.33 (0.95, 3.70), P = 0.001), BMI (WMD (95% CI) = 1.68 (1.37, 1.99) kg/m2, P < 0.001), and age (WMD (95% CI) = 9.95 (5.05, 14.86) years, P < 0.001) were significantly related to post-operative recurrence in patients with LDH after PELD. Significant publication bias was not observed among studies in all outcome indicators.

Conclusion
Our findings reveal that high levels of age, BMI, and SROM, history of T2DM or smoking, or more MC may be correlated with post-operative recurrence after PELD.
Evaluation of bone mineral density in adolescent idiopathic scoliosis using a three-dimensional finite element model: a retrospective study
Authors: Han Chaofan , Zhou Chaochao , Zhang Hanwen , Yin Peng , Guo Runsheng , Wang Wei , Zhang Yiqi , Cha Thomas , Li Guoan , Hai Yong 
Published: December 2023

Abstract
Background
Adolescent idiopathic scoliosis (AIS) is often accompanied by osteopenia and osteoporosis, which can cause serious complications. The aim of this study was to determine the specific bone mineral density (BMD) of each vertebral body in patients with AIS using biomechanical finite element modeling based on three-dimensional (3D) reconstruction.

Methods
This retrospective study involved 56 patients with AIS. Computed tomography (CT) and radiography were performed. Spinal vertebrae were segmented from the spinal CT images of patients with AIS to reconstruct 3D vertebral models. The vertebral models were meshed into tetrahedral finite elements to assess the BMD.

Results
The mean main curve Cobb angle was 88.6 ± 36.7°, and the mean kyphosis angle was 36.8 ± 31.5°. The mean BMD of the global spine was 0.83 ± 0.15 g/cm2. The highest BMD was measured on the concave side of the apex (0.98 ± 0.16 g/cm2). Apical vertebral BMD was negatively correlated with age and height (r = − 0.490, p = 0.009 and r =  − 0.478, p = 0.043, respectively). There were no significant differences in BMD values between the concave and convex sides (p > 0.05).

Conclusions
The 3D finite element modeling of BMD in patients with AIS is a reliable and accurate BMD measurement method. Using this method, the overall BMD of patients with AIS was shown to gradually decrease from the top to the bottom of the spine. Our findings provide valuable insights for surgical planning, choice of screw trajectories, and additional biomechanical analyzes using finite element models in the context of scoliosis.
Glass ornaments from southwestern Taiwan: new light on maritime glass exchange across Southeast, South and West Asia in the early-mid 1st millennium CE
Authors: Wang Kuan-Wen , Dussubieux Laure , Iizuka Yoshiyuki , Li Kuang-ti , Tsang Cheng-hwa 
Published: December 2023

Abstract
A total of 146 glass samples from Daoye, Daoye South, and Wujiancuo in southwestern Taiwan were subjected to elemental analysis using LA-ICP-MS and SEM–EDS. These samples cover a time span from the first to the eighth century CE. The results provide evidence of the existence of multiple long-distance glass exchange networks that directly or indirectly connected Taiwan to Southeast Asia, South Asia, West Asia, and possibly the Mediterranean region. The predominance of the South Asian m-Na-Al glass sub-type 1 suggests that Taiwan mainly participated in the South China Sea maritime glass exchange network, while the identification of a newly recognised sub-type, m-Na-Al low Al low Ca, indicates the possibility of small-scale glass production workshops or a less controlled recipe for m-Na-Al glass production. Furthermore, this research reveals compelling evidence linking early v-Na-Ca glass found in Taiwan to origins in Mesopotamia or Sasanian territories, with the secondary production areas remain unclear. In addition, a potash glass and a Roman HIMT glass were also discovered. The chemical profiles of the potash glass do not align with those of early potash glass, while the HIMT glass can be attributed to the Roman Mediterranean. Taken together, these findings shed light on the intricate maritime exchange networks that operated over vast distances, spanning from the eastern part of the South China Sea to West Asia, covering over eight thousand kilometers. This study thus addresses a significant research gap regarding the maritime exchange of glass during the understudied period of the early to mid-1st millennium CE around the South China Sea and beyond.
An expectancy value theory (EVT) based instrument for measuring student perceptions of generative AI
Authors: Chan Cecilia Ka Yuk , Zhou Wenxin 
Published: December 2023

AbstractThis study examines the relationship between student perceptions and their intention to use generative artificial intelligence (GenAI) in higher education. With a sample of 405 students participating in the study, their knowledge, perceived value, and perceived cost of using the technology were measured by an Expectancy-Value Theory (EVT) instrument. The scales were first validated and the correlations between the different components were subsequently estimated. The results indicate a strong positive correlation between perceived value and intention to use generative AI, and a weak negative correlation between perceived cost and intention to use. As we continue to explore the implications of GenAI in education and other domains, it is crucial to carefully consider the potential long-term consequences and the ethical dilemmas that may arise from widespread adoption.
Patient Engagement in Research Scale (PEIRS-22): Danish translation, applicability, and user experiences
Authors: Christiansen Mille Guldager , Pappot Helle , Hamilton Clayon , Lund-Jacobsen Trine , Kristensen Anne Wilhøft , Nordentoft Sara , Høeg Beverley Lim , Bidstrup Pernille , Nielsen Iben Husted , Ulstrup Jane , Trip Anouk Kirsten , Jarden Mary , Piil Karin 
Published: December 2023

Abstract
Background
Patient and Public Involvement (PPI) in health research is gaining increased attention and acceptance worldwide. Reliable measurements are crucial to accurately assess, monitor, and evaluate patient involvement efforts in research. The Patient Engagement in Research Scale (PEIRS-22) measures meaningful patient and family caregiver engagement in research. This study focuses on three primary objectives: (1) translation of the PEIRS-22 from English to Danish, followed by linguistic validation and cultural adaptation; (2) assessing the applicability of the Danish PEIRS-22; and (3) focus group interviews to explore the user experiences of PPI.

Methods
A three-phase multi-method study was conducted. In phase one, the PEIRS-22 was translated, linguistically validated and culturally adapted to Danish. In phase two individuals from three distinct patient cancer advisory boards responded to the Danish version of PEIRS-22 to assess its applicability. Three focus group interviews were conducted in phase three, involving individuals from three patient cancer advisory boards.

Results
The translation process resulted in a Danish version of PEIRS-22, conceptually and culturally equivalent to the English version. Overall, among individuals of the three advisory boards (n = 15) the applicability was found to be satisfactory, with no missing data and all items completed. The total PEIRS-22 score among the three advisory boards was 85.2 out of a possible 100, with higher scores indicating greater meaningful involvement. A nested sample of the three patient cancer advisory boards (n = 9) participated in focus group interviews. The analysis yielded four themes: (1) The Danish PEIRS-22 captured the intended cultural meaning and contributed to self-reflection, (2) Internal motivation is a driver for involvement (3), Involvement brought a personal sense of empowerment and (4) Meaningful involvement collaborations are fostered by a trustful atmosphere.

Conclusions
The PEIRS-22 questionnaire has been translated, linguistically validated, and culturally adapted into Danish. We propose that the PEIRS-22 is now ready for use in Danish populations. This study provides a Danish version of the questionnaire that can be used to develop patient-centred practices and foster meaningful involvement and collaborations between patients and researchers in the field of cancer research in Denmark. Personal benefits of participating in PPI can vary, and we recommend using PEIRS-22 in conjunction with a qualitative approach to better explore perspectives on meaningful involvement.

Trial registration

The study was registered prospectively on October 22, 2022, by the Danish Data Protection Agency (jr. nr. P-2022–528).
Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood–brain barrier dysfunction
Authors: Zeng Zongwei , Liang Liang , Feng Zhou , Guo Peiwen , Hao Xiaoke , Xian Jishu , Feng Hua , Chen Yujie , Chen Zhi 
Published: December 2023

Abstract
Background
Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently, especially in warfarin-associated intracerebral hemorrhage (W-ICH). In the present study, we employ the warfarin-associated intracerebral hemorrhage (W-ICH) rat model, to explore the efficacy and potential mechanism of glibenclamide pretreatment on hematoma expansion after intracerebral hemorrhage, hoping to provide proof of concept that glibenclamide in stroke primary and secondary prevention is also potentially beneficial for intracerebral hemorrhage patients at early stage.

Methods
In the present study, we tested whether glibenclamide, a common hypoglycemic drug, could attenuate hematoma expansion in a rat model of W-ICH. Hematoma expansion was evaluated using magnetic resonance imaging; brain injury was evaluated by brain edema and neuronal death; and functional outcome was evaluated by neurological scores. Then blood–brain barrier integrity was assessed using Evans blue extravasation and tight junction-related protein.

Results
The data indicated that glibenclamide pretreatment significantly attenuated hematoma expansion at 24 h after W-ICH, thus mitigating brain edema and neuronal death and promoting neurological function recovery, which may benefit from alleviating blood–brain barrier disruption by suppressing matrix metallopeptidase-9.

Conclusions
The results indicate that glibenclamide pretreatment in stroke primary and secondary prevention might be a promising therapy for hematoma expansion at the early stage of W-ICH.
MI-Common Data Model: Extending Observational Medical Outcomes Partnership-Common Data Model (OMOP-CDM) for Registering Medical Imaging Metadata and Subsequent Curation Processes
Authors: Kalokyri Varvara , Kondylakis Haridimos , Sfakianakis Stelios , Nikiforaki Katerina , Karatzanis Ioannis , Mazzetti Simone , Tachos Nikolaos , Regge Daniele , Fotiadis Dimitrios I. , Marias Konstantinos , Tsiknakis Manolis 
Published: December 2023

PURPOSE The explosion of big data and artificial intelligence has rapidly increased the need for integrated, homogenized, and harmonized health data. Many common data models (CDMs) and standard vocabularies have appeared in an attempt to offer harmonized access to the available information, with Observational Medical Outcomes Partnership (OMOP)-CDM being one of the most prominent ones, allowing the standardization and harmonization of health care information. However, despite its flexibility, still capturing imaging metadata along with the corresponding clinical data continues to pose a challenge. This challenge arises from the absence of a comprehensive standard representation for image-related information and subsequent image curation processes and their interlinkage with the respective clinical information. Successful resolution of this challenge holds the potential to enable imaging and clinical data to become harmonized, quality-checked, annotated, and ready to be used in conjunction, in the development of artificial intelligence models and other data-dependent use cases. METHODS To address this challenge, we introduce medical imaging (MI)-CDM—an extension of the OMOP-CDM specifically designed for registering medical imaging data and curation-related processes. Our modeling choices were the result of iterative numerous discussions among clinical and AI experts to enable the integration of imaging and clinical data in the context of the ProCAncer-I project, for answering a set of clinical questions across the prostate cancer's continuum. RESULTS Our MI-CDM extension has been successfully implemented for the use case of prostate cancer for integrating imaging and curation metadata along with clinical information by using the OMOP-CDM and its oncology extension. CONCLUSION By using our proposed terminologies and standardized attributes, we demonstrate how diverse imaging modalities can be seamlessly integrated in the future.
Health Insurance Literacy Improvements Among Recently Diagnosed Adolescents and Young Adults With Cancer: Results From a Pilot Randomized Controlled Trial
Authors: Kirchhoff Anne C. , van Thiel Berghuijs Karely M. , Waters Austin R. , Kaddas Heydon K. , Warner Echo L. , Vaca Lopez Perla L. , Perez Giselle K. , Ray Nicole , Chevrier Amy , Allen Karlie , Fair Douglas B. , Tsukamoto Tomoko , Lewis Mark A. , Haaland Ben , Park Elyse R. 
Published: December 2023

PURPOSE Adolescents and young adults (AYAs; age 18-39 years) with cancer report needing support with health insurance. We conducted a pilot randomized controlled trial to assess the feasibility and acceptability of a virtual health insurance navigation intervention (HIAYA CHAT) to improve health insurance literacy (HIL), awareness of Affordable Care Act (ACA) protections, financial toxicity, and stress. MATERIALS AND METHODS HIAYA CHAT is a four-session navigator delivered program; it includes psychoeducation on insurance, navigating one's plan, insurance-related laws, and managing costs. Participants were eligible if they could access an internet-capable device, were <1 year from diagnosis, and received treatment from University of Utah Healthcare or Intermountain Health systems. We assessed the feasibility, acceptability, and preliminary efficacy of HIAYA CHAT compared with usual navigation care, including HIL (nine items), insurance knowledge (13 items), ACA protections (eight items), COmprehensive Score for financial Toxicity (COST; 11 items), and Perceived Stress Scale (PSS; four items), using t tests and Cohen's d. RESULTS From November 2020 to December 2021, N = 86 AYAs enrolled (44.6% participation) and 89.3% completed the 5-month follow-up survey; 68.6% were female, 72.1% were White, 23.3% were Hispanic, 65.1% were age 26-39 years, and 87.2% were privately insured. Of intervention participants (n = 45), 67.4% completed all four sessions; among an exit interview subset (n = 10), all endorsed the program (100%). At follow-up, compared with usual navigation care, intervention participants had greater improvements in HIL, insurance and ACA protections knowledge, and PSS; effect sizes ranged from moderate to large (0.42-0.77). COST did not differ. CONCLUSION The results support the feasibility and acceptability of HIAYA CHAT with related improvements in HIL.
Characterizing Opioid Prescribing Trends of Medical Oncologists From 2013 to 2019: Analysis From the Centers for Medicare & Medicaid Services Medicare Part D Prescribers Database
Authors: Korst Mark R. , Santos Teles Marco , Choudhry Hassaam S. , Santitoro Joseph G. , Garcia Daniel J. , Schwab Sophia Marie T. , Kra Joshua A. 
Published: December 2023

PURPOSE Opioid prescribing trends in medical oncology are poorly defined past 2017, the year after the CDC updated opioid prescription guidelines in noncancer settings. We aim to characterize pain management by medical oncologists by analyzing opioid and gabapentin prescribing trends from 2013 to 2019, identify physician-related factors associated with prescribing patterns, and assess whether CDC guidelines for nononcologic settings changed prescribing patterns. METHODS The Centers for Medicare & Medicaid Services (CMS) Medicare Part D Prescribers—by Provider, CMS Medicare Part D Prescribers—by Provider and Drug, and CMS Medicare Physician National Downloadable files from 2013 to 2019 were merged by National Provider Identification. The database included physicians' sex, years of practice, regions, and practice settings. Multivariable binary logistic regression identified significant predictors of total opioid, long-acting opioid, and gabapentin prescriptions. RESULTS Binary logistic regression modeling revealed no significant difference in mean daily total opioid prescriptions from 2013 to 2017. Daily opioid prescriptions by medical oncologists decreased significantly after 2017 ( P < .001). Increased opioid prescribing was associated with physician male sex ( P < .001), practicing over 10 years ( P < .001), and practice in nonurban areas ( P < .001). Opioid prescribing was greatest in the South and Midwest United States ( P < .001). The same patterns were observed with total long-acting opioid prescriptions, whereas gabapentin prescribing increased from 2013 to 2019 ( P < .001). CONCLUSION Opioid prescriptions by medical oncologists decreased significantly from 2013 to 2019, but this decrease was most substantial from 2017 to 2019. These results may imply that the 2016 CDC guidelines influenced medical oncologists, particularly more junior physicians in urban settings, to manage chronic cancer pain with alternative therapies.
Why Does the Inflation Reduction Act Exclude Expensive Cancer Treatments in Price Negotiations?
Authors: Horn Danea M. , Jacobson Mireille , Alpert Abby E. , Duggan Mark G. 
Published: December 2023

PURPOSE The Inflation Reduction Act (IRA) includes provisions for price negotiations of certain high-spending drugs in Medicare Parts B and D. This provision received considerable attention from those interested in the costs of cancer care since Medicare covers most patients with cancer and many cancer drugs are expensive. We simulate how many cancer drugs may be eligible for IRA price negotiations and examine the reasons that many are likely to be excluded from negotiation. METHODS This study uses 2021 Medicare Fee-for-Service Part B and Part D prescription drugs expenditure data. Cancer drugs were identified using the SEER Program list of cancer medications. Our measures included total spending, beneficiary users, and spending-per-beneficiary for all cancer drugs covered under Medicare. Each drug was evaluated for eligibility on the basis of IRA negotiation provisions, including estimated loss of patent exclusivity, current competitors, and orphan drug designation. RESULTS We found that very few cancer drugs will meet the IRA eligibility thresholds to be included in negotiations. We estimate that only 2.2% of beneficiaries with cancer will see lower costs because of the IRA negotiations. The main reason for this is that although novel cancer drug treatments are priced high, they generally treat relatively few beneficiaries and thus do not meet negotiation eligibility criteria, which are primarily based on a ranking of total spending. CONCLUSION The IRA negotiation provisions will have limited impact on cancer drug prices and will likely leave most patients with cancer exposed to high drug costs.
Characterizing Genetic Alterations Related to Radioiodine Avidity in Metastatic Thyroid Cancer
Authors: Mu Zhuanzhuan , Zhang Xin , Sun Di , Sun Yuqing , Shi Cong , Ju Gaoda , Kai Zhentian , Huang Lisha , Chen Libo , Liang Jun , Lin Yansong 
Published: December 2023

Abstract

Context
Patients with differentiated thyroid cancer (DTC) with distant metastasis (DM) are usually not recognized as radioactive iodine (RAI)-refractory DTC in a timely manner. The elucidation of genetic features related to RAI uptake patterns may shed light on the early recognition of RAI-refractory DTC.

Objective
This work aimed to elucidate the underlying molecular features behind different RAI uptake patterns.

Methods
A total of 214 patients with DM-DTC were retrospectively included in the analysis. RAI uptake patterns were defined as initially RAI refractory (I-RAIR) and initially RAI avid (I-RAIA) according to the first post-treatment scan, then I-RAIA was further divided into continually RAIA (C-RAIA), partly RAIR (P-RAIR), and gradually RAIR (G-RAIR) according to subsequent scans. The molecular subtype groups—BRAFV600E mutated, RAS mutated, fusions, and others—were classified according to main driver genes status.

Results
BRAF, TERT promoter, and TP53 mutations are more frequently detected in the I-RAIR pattern while RET fusions and RAS mutations are more frequent in the I-RAIA pattern. A late-hit mutation including TERT, TP53, or PIK3CA is more common in I-RAIR than that in I-RAIA (50.0% vs 26.9%, P = .001), particularly for those with RAS mutations in the I-RAIR group, always accompanied by TERT promoter. Isolated RET fusions accounts for 10% of I-RAIR. When compared among driver gene groups, BRAFV600E-mutated tumors have a higher rate of the I-RAIR pattern (64.4%) than RAS-mutated (4.5%, P &lt; .001) and fusion-positive (20.7%, P &lt; .001) tumors. In I-RAIA subgroups, BRAFV600E-mutated tumors have lower prevalence of the C-RAIA pattern than those with RAS mutation or fusions.

Conclusion
Patients with the I-RAIR pattern predominantly featured mutations of the BRAF and/or TERT promoter, of which RAS mutations were usually accompanied by late-hit mutations, while fusions mostly occurred alone.