bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It's Gonna Be a Stressful Day!”: How Stressor Forecasting Moderates Stress and Wellbeing in Real‐World Contexts
Authors: Elsey Jamie S. , Dutton Sam , Lohani Monika 
Published: February 2025

ABSTRACTStressor forecasting predicts the likelihood of a stressful event occurring in an upcoming timeframe and can significantly influence everyday experiences. The current study aimed to understand how stressor forecasting may moderate links between hourly stress and affective experiences over the course of a day. An ecological momentary assessment approach was used to collect data from 304 participants about their predicted stressor forecasting and hourly stress to personally relevant stressors and affective experiences 10 times within a day. We predicted that stressor forecasting would moderate the relationship between stress and affective experiences (separately for negative and positive affect). Stressor forecasting significantly moderated the links between stress and negative affect, but not between stress and positive affect. These findings emphasize the meaningful implications that adverse stressor forecasting can have on daily wellbeing, which may lead to the development and maintenance of chronic stress.
Validity and reliability of the Japanese version of the Child and Adolescent Behavior Inventory: Parent version
Authors: Hashimoto Ryusaku , Sueda Keitaro , Tsuji Yui , Nakashima Yota , Yagyu Kazuyori , Takeda Toshinobu 
Published: February 2025

AbstractAimWe developed a Japanese version of the Child and Adolescent Behavior Inventory (CABI) and evaluated its validity and reliability.MethodsA total of 2433 parents and 108 students in grades 4 and above participated in this study. First, we assessed the agreement between the parents' evaluations of internalizing disorders (anxiety and depression modules) and their children's self‐reports. The criterion‐related validity of attention deficit hyperactivity disorder (ADHD)‐inattention, ADHD‐hyperactivity/impulsivity, and oppositional defiant disorder (ODD) modules was also evaluated. Subsequently, we investigated whether cognitive disengagement syndrome (CDS) items differed from the ADHD items through factor analysis and examined the relationship between CDS and internalizing problems. Finally, we established normative data to adapt the CABI for use in the Japanese population.ResultsParents' observational evaluations of internalizing disorders showed moderate agreement with children's self‐reports. The ADHD‐inattention, ADHD‐hyperactivity/impulsivity, and ODD modules demonstrated moderate to high criterion‐related validity. Factor analysis revealed that the CDS module assesses symptoms distinct from ADHD symptoms. In the Japanese population, CDS exhibited a two‐factor structure (daydreaming and mental confusion), with developmental changes observed across age groups. The internal consistency and test–retest reliability of the CABI are moderate to high.ConclusionsThe scores of each CABI module were found to be reliable and valid within the Japanese sample. Future clinical research should focus on the evaluation of CDS, which is often comorbid with ADHD.
ShiftScan: A tool for rapid analysis of high‐throughput differential scanning fluorimetry data and compound prioritization
Authors: Waterworth Samantha C. , Shenoy Shilpa R. , Sharma Nirmala D. , Wolcott Chris , Donohue Duncan E. , O'Keefe Barry R. , Beutler John A. 
Published: February 2025

AbstractDifferential scanning fluorimetry (DSF) can be an effective high‐throughput screening assay in drug discovery for detecting protein‐compound interactions that stabilize or destabilize macromolecules. Due to the magnitude and quality of the data produced by this biophysical assay, analyzing and prioritizing compounds from large‐scale DSF data sets has proven challenging to the research community. Here, we present ShiftScan—a powerful, stand‐alone tool designed for the rapid analysis of DSF data and compound prioritization based on thermal transition patterns. ShiftScan accurately and quickly predicts melting temperatures (Tm values) from both canonical and non‐canonical transition patterns, efficiently filtering out spurious data to minimize false positives. We report on the use of this tool for data analysis of screens involving both pure compound and natural product fraction libraries and provide the software to the screening community to aid in the discovery of molecularly‐targeted compounds. Instructions for installation and usage of ShiftScan can be found at our GitHub repository: https://github.com/samche42/ShiftScan.
TYMIRIUM® technology: the discovery of Cyclobutrifluram
Authors: Flemming Anthony , Guest Marcus , Luksch Torsten , O'Sullivan Anthony , Screpanti Claudio , Dumeunier Raphael , Gaberthüel Matthias , Godineau Edouard , Harlow Philippa , Jeanguenat André , Kurtz Benedikt , Maienfisch Peter , Mondière Régis , Pierce Andy , Slaats Brigitte , Smejkal Tomas , Loiseleur Olivier 
Published: February 2025

AbstractSyngenta responded to significant agricultural losses caused by plant‐parasitic nematodes by initiating a next‐generation nematicide discovery program. This effort led to the development of TYMIRIUM® technology, a nematicide and fungicide solution containing Cyclobutrifluram as its active ingredient. In 2022, this innovative solution received its first registration. Cyclobutrifluram, a chiral phenyl‐cyclobutyl‐pyridineamide, demonstrates wide‐ranging effectiveness against all economically important plant parasitic nematodes and several soil‐borne diseases, particularly those caused by Fusarium species. The discovery of this molecule involved hit the identification, lead exploration, and optimization stages, which made use of various methods such as phenotypic nematicide screening platforms, targeted screening libraries, rapid target identification through biochemical and genetic approaches, in vitro assays for structure–activity relationship (SAR) analysis, and homology models for structure‐based design. This multi‐disciplinary approach led to the successful identification of Cyclobutrifluram as the key component in TYMIRIUM® technology. © 2025 Society of Chemical Industry.
Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions
Authors: Thakur Aarzoo , Mathialagan Sumathy , Kimoto Emi , Varma Manthena V. S. 
Published: February 2025

ABSTRACTPyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from five independent studies (conducted/supported by Pfizer), and subsequently developed mechanistic physiologically based pharmacokinetic (PBPK) model to assess its effectiveness in biomarker‐informed drug–drug interaction (DDI) predictions. Meta‐analysis suggested that the inter‐individual variability in PDA plasma concentration was ~40% across all five studies (n = 71 subjects). While sex‐dependent differences were not evident, the baseline plasma PDA levels were significantly higher (38%, p < 0.05) in White males compared to Japanese males. Correspondingly, the amount of PDA excreted in urine and renal clearance were significantly higher (p < 0.05) in Japanese males (1.5‐ and 2.2‐fold, respectively), compared to White males. A PBPK model considering relative activity factor‐based scaling of in vitro transport data indicated > 80% contribution by OAT3 to the renal clearance of PDA. The baseline plasma concentrations across multiple studies were recovered by the model; and using in vitro inhibition potency data, the model predicted effect of OAT inhibitors (probenecid, ritlecitinib and tafamidis) on PDA pharmacokinetics. Furthermore, DDIs with OAT3 object drug, furosemide, were well‐predicted by the biomarker‐informed PBPK model. PDA data and the modeling approach indicated lack of clinically‐relevant OAT inhibition with ritlecitinib and tafamidis. Overall, this study presents PDA as a reliable biomarker to assess OAT3‐mediated renal DDIs with moderate inter‐subject and inter‐study variability.
Climate Change, Land Degradation and Sustainable Development in Africa? Evidence for AfCFTA Implementation
Authors: Okunade Solomon O. , Assoua Joe E. , Binuomote Samuel O. , Osabuohien Evans , Eric Bomdzele , Enwa Sarah , Omosehin Olanrewaju 
Published: February 2025

ABSTRACTThis study assesses the effect of climate change and land degradation on Sustainable Development Goal (SDG) 2 indicators (agricultural productivity, crop yields, agricultural output per capita, livelihoods, and economic growth) for different African regions. Using data from 46 African countries (1990–2022), we employ the Panel‐Corrected Standard Errors (PCSE) and the Feasible Generalized Least Squares (FGLS) techniques to show that both climate change and land degradation have substantial negative impacts on the pursuit of achieving SDG2, especially in agriculture, forestry, and fishing. We also show that some specific indicators of climate change, like rainfall patterns, had positive impacts on SDG2, while indicators of land degradation such as deforestation and resource depletion hindered progress. Thus, the study provides evidence of a critical need for integrated policies and strategies encompassing climate change adaptation and mitigation, land restoration and conservation, and sustainable agricultural practices in Africa.
Enhancing the Solubility of Dihomo‐gamma‐Linolenic Acid Using Natural Deep Eutectic Solvents for Human Tumors Therapy Development
Authors: Hayyan Adeeb , Al‐Maari Mohammed Abobakr , Abed Khalid M. , Alanazi Yousef Mohammed , Saleh Jehad , Gupta Bhaskar Sen , Kang Devin Chen Yung , Hizaddin Hanee F. , Salleh M. Zulhaziman M. 
Published: February 2025

AbstractThis study investigated the potential of natural deep eutectic solvents (NADES) for dihomo‐γ‐linolenic acid (DGLA) solubility. The conductor‐like screening model for real solvents (COSMO‐RS) was used in this study as a computational software tool to predict the relative solubilization ability of 50 different NADES for DGLA. Furthermore, the solubilization mechanisms were examined by analyzing the activity coefficients, sigma profile (σ‐profile), and the excess Gibbs free energy. The results reveal that NADES, consisting of menthol and camphor, Men/Cam (1:1), exhibited the highest capacity (6.352) for DGLA capacity, highlighting its potential for enhanced delivery and application. Furthermore, the σ‐profile analysis and excess Gibbs free energy calculations confirm strong interaction and miscibility of Men/Cam (1:1) with DGLA. This computational approach offers valuable guidance for selecting the optimal NADES compositions to improve DGLA solubility, potentially advancing cancer therapy strategies and contributing to pharmaceutical science and drug delivery. This is the first study to apply COSMO‐RS in designing and developing a promising therapeutic agent for human tumor treatment.
Progress in Advanced Composite Hydrogel Dressings: Innovative Materials and Designs for the Treatment of Chronic Wounds
Authors: Sun Zhongqi , Zhao Li , Wang Fenglong , Zhao Degang , Jiang Yanyan 
Published: February 2025

AbstractChronic wounds, as a kind of long‐term disease that is difficult to cure, are challenged in healthcare, placing substantial physical, emotional, and economic burdens on patients and society. Effective treatment of chronic wounds is essential for improving patient quality of life, reducing healthcare costs, and alleviating the strain on medical resources. Hydrogel materials have emerged as promising candidates for chronic wound treatment due to their exceptional adaptability to wound environments and the ability to deliver various therapeutic agents, effectively promoting the healing of chronic wounds. However, the wide array of available materials with diverse functionalities presents a challenge in selecting the most appropriate components for synthesizing hydrogel wound dressings. This review summarizes the common hydrogel materials, including their properties, cross‐linking methods, and applications. Additionally, it systematically categorizes different therapeutic agents, elucidating their action mechanisms and therapeutic effects. Furthermore, this work offers guidance on material selection and hydrogel dressing design based on the characteristics of chronic wounds. Finally, the challenges and future perspectives of composite hydrogels in the field of wound dressings are discussed. This review provides readers with a comprehensive understanding of hydrogel wound dressings and offers a reliable basis for selecting appropriate materials to synthesize ideal hydrogel wound dressings for chronic wounds.
Electrochemical Approaches for Radioactive Wastewater Treatments
Authors: Sholikhah Mu'nisatun , Harmesa Harmesa , Sinaga Septy , Putri Yulia Mariana Tesa Ayudia , Fisli Adel , Ivandini Tribidasari A. 
Published: February 2025

AbstractRadioactive waste has become a critical concern due to its adverse impacts on the sustainability of living organisms and the environment. The waste is widely generated from various nuclear activities, such as nuclear power generation, healthcare, industry, mining, and research. Recently, there has been an intense focus on developing electrochemical techniques for radioactive waste management as these techniques offer several advantages compared to other methods, including cleanliness, versatility, environmental friendliness, ease of operation, and good compatibility with other waste management methods. This article aims to provide a comprehensive overview of the electrochemical‐based methods development and their capabilities to extract various radionuclides from liquid wastes. This article follows a traditional literature review method, unsystematically collecting publications from 2009 to 2024 and analyzing them using a theoretical approach and comparative data. Various electrochemical techniques, such as electrodeposition, electro‐Fenton, electrodialysis, electrocoagulation flotation, microbial fuel cells, electrosorption/capacitive deionization, and photoelectrocatalysis, have been discussed. The main focus includes radionuclide types, electrodes, process conditions, as well as radionuclide extraction effectiveness. This review highlights the application of electrochemical technologies in radioactive waste treatment and provides a comparative analysis to support future research and development.
Phytochemical Profiling and Bioactivity of Leucosceptrum Canum Extracts from the Uttarakhand Himalayas: Nematicidal and Acetylcholinesterase Inhibitory Potential
Authors: Karakoti Himani , Kumar Ravendra , Mahawer Sonu Kumar , Prakash Om , Kumar Satya , Rawat Shilpi , Rawat D.S. , Maslowiecka Jolanta , Isidorov Valery A. , de Oliveira Mozaniel Santana 
Published: February 2025

AbstractThis study includes a comparative investigation to analyze the phytochemical composition, nematicidal efficacy, in vitro AChE inhibitory activity, and molecular docking study of Leucosceptrum canum. (LC) extracts. Various polarity solvent extracts including hexane (LCHE), dichloromethane (LCDE), and methanol (LCME) were prepared from LC aerial parts using Soxhlet extraction. Phytochemical analysis was done using GC‐MS technique to identify and quantify the presence of bioactive compounds revealing that LCHE is abundant in fatty acids (43.85%) and triterpenoid (24.18%) compounds. LCDE, on the other hand, is characterized by a predominance of flavones and flavonoids (53.75%), while LCME is rich in phenols and phenolic compounds (34.83%). Nematicidal efficacy was evaluated against root knot nematode in terms of egg hatchability inhibition and mortality assay. LCDE exhibited significant nematicidal activity, with 74.67% mortality at 1000 µg/mL after 96 h of exposure. LCHE and LCDE showed maximum egg hatching inhibition of 78.94% at 1000 µg/mL after 96 h. The in vitro assay was conducted to assess acetylcholinesterase inhibition activity revealing that LCDE exhibited the most potent inhibition (IC50 = 26.08 µg/mL), followed by LCHE (IC50 = 38.85 ± 0.85 µg/mL) and LCME (IC50 = 54.66 ±1.03 µg/mL). Molecular docking revealed binding interactions between the bioactive compounds identified in LC extracts and the catalytic domain of AChE.
Reversible Microadhesives with Good Adhesion Anisotropy via Dual‐Gradient Modulus Constructing
Authors: Li Xiaohui , Liu Shijie , Tian Jinfeng , Ding Weiyi , Han Shitian , Yang Gengchen , Chen Yang , Liang Mei , Liu Pengbo , Heng Zhengguang , Zhou Shengtai , Luo Yinfu , Yan Liwei , Xia Shuang , Zou Huawei 
Published: February 2025

AbstractBioinspired microadhesives can generate strong adhesion at the interface through van der Waals forces, demonstrating promising potential applications across various fields. However, the inherent conflicts between microstructural stability and compliance, as well as strong adhesion and easy detachment, significantly hinder the development and practical applications of microadhesives. In this work, wedged microadhesives (WMs) of dual‐gradient modulus are fabricated via magnetically assisted soft‐molding. The dual‐gradient modulus WMs exhibit a maximum shear adhesion performance of 4.9 N cm−2 and a minimum normal adhesion performance of 0.13 N cm−2 under the same preload, achieving an excellent anisotropy ratio (AR) of up to 37.7. The dual‐gradient modulus generates a greater modulus gradient difference, with the low modulus facilitating to maintain well‐conformal contact, while the high modulus enhances the shear adhesion and normal detachment capabilities, which simultaneously improve the long‐term stability. Additionally, a quadruped gripping mechanism is designed and exhibited stable grasping and on‐demand rapid release when integrated with the WMs, demonstrating an excellent anisotropic adhesion performance. The dual‐gradient modulus WMs provide a valuable solution for designing microadhesives that exhibit both structural stability and compliance, along with strong adhesion and easy detachment. These findings will greatly benefit the applications of reversible microadhesives in on‐orbit servicing technology.
ESIPT Nano‐Emitter to Probe Lysosome Biogenesis in Live Cells
Authors: Virmani Mishika , Jayakannan Manickam 
Published: February 2025

AbstractEndosome‐lysosome fusion and endo‐lysosome fission‐mediated lysosome biogenesis are crucial in regulating cellular health, and their dysregulation signifies disease. Tracking such intricate events with minimal disturbance remains elusive due to the scarcity of single‐component synthetic probes capable of distinctly and simultaneously labeling both endosomes and lysosomes. Here, an amphiphilic π–conjugated imine probe is designed that forms micellar self‐assemblies in water, called Nano‐emitter, which distinctly and simultaneously labels endosomes and lysosomes upon monochromatic‐wavelength excitation. ESIPT (Excited State Intramolecular Proton Transfer) active Nano‐emitter shows red fluorescence at endosomal pH. Its hydrolysis to fluorescent amine, PEG‐Naph at lysosomal pH illuminated lysosomes fluorescent green, with both imine and amine forms excitable using a 405 nm confocal laser. The two‐color labeling of endosomes and lysosomes enabled tracking of their fusion and lysosome‐biogenesis processes in living cells. Using multiplexed time‐lapse imaging with Nano‐emitter and anti‐cancer drug doxorubicin, the role of these processes is investigated in lysosome‐mediated doxorubicin sequestration in MCF‐7 cells. The results show that endosomes as well as endo‐lysosomes also sequestered doxorubicin apart from lysosomes. Interestingly, doxorubicin‐sequestered endo‐lysosomes underwent fission and generated more doxorubicin‐sequestered lysosomes, preventing the drug's nuclear localization. Such versatile probes can enhance the understanding of drug sequestration and foster therapeutic strategies.
Biomineralize Mitochondria in Metal‐Organic Frameworks to Promote Mitochondria Transplantation From Non‐Tumorigenic Cells Into Cancer Cells
Authors: Zhou Jun‐Nian , Liu Chang , Wang Yonghui , Guo Yong , Xu Xiao‐Yu , Vuorimaa‐Laukkanen Elina , Koivisto Oliver , Filppula Anne M. , Ye Jiangbin , Zhang Hongbo 
Published: February 2025

ABSTRACTMitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for therapeutic use in treating these diseases. However, transplantation process is notably challenging due to very low efficiency and rapid loss of bioactivity post‐isolation, leading to poor reproducibility and reliability. In this study, we develop a novel strategy to form a nanometer‐thick protective shell around isolated mitochondria using Metal‐Organic Frameworks (MOFs) through biomineralization. Our findings demonstrate that this encapsulation method effectively maintains mitochondria bioactivity for at least 4 weeks at room temperature. Furthermore, the efficiency of intracellular delivery of mitochondria is significantly enhanced through the surface functionalization of MOFs with polyethyleneimine (PEI) and the cell‐penetrating peptide Tat. The successful delivery of mitochondria isolated from non‐tumorigenic cells into cancer cells results in notable tumor‐suppressive effects. Taken together, our technology represents a significant advancement in mitochondria research, particularly on understanding their role in cancer. It also lays the groundwork for utilizing mitochondria as therapeutic agents in cancer treatment.
A Systemic Reflection On Why Biology Is Best : E(s) ∞$$ \infty $$mc2Sentience, Consciousness and Transcendance?
Authors: McIntyre‐Mills J. J. 
Published: February 2025

ABSTRACTThe short essay makes a case that a post biological world will be a devolution. Sentience is a relational process linked with the awe and wonder we experience in relation to one another and our shared habitat. The voiceless need to be protected by extending solidarity on the basis of sentience—a normative plea, but also on the basis of pragmatism—as our shared existence in a shared habitat is co‐determined. Posthuman beings in a digital world could have a very different existence in relationship to the few remaining human beings who could perhaps self‐select through their ability to protect themselves at the expense of others and our shared habitat. Evolution rests on both the ability to compete and to co‐operate. The former has been emphasised to the extent that it threatens our shared existence through commodification of life and the destruction of other species.