bluuebunny/crossref_metadata_2025_split huggingface dataset:
British and Irish newspapers implicitly support single-use masks over reusable face coverings
Authors: Augé Anaïs , Tenbrink Thora , Spear Morwenna , Abrams Nathan 
Published: October 2023

IntroductionThe environmental impact of waste caused by single-use masks or face coverings is an under-considered effect associated with the COVID-19 pandemic. The combination of the protective purpose of face masks and their potential environmental impacts through littering or waste management means the wearing of face masks is simultaneously associated with the health crisis and creation of a new environmental challenge, combining two strands of journalism.MethodsOur study demonstrates how the discourse in British and Irish newspapers in the March 2020-December 2021 time frame relates to this problem. By a combination of quantitative and qualitative discourse analysis, we identify concepts commonly associated with the terms “face-covering” and “mask,” particularly concerning whether they refer to a disposable or reusable item.ResultsResults suggest that the newspaper discourse generally favored references to single-use surgical masks. Newspapers reported on the environmental impact of face masks only in very limited ways.DiscussionWe propose that the increase in waste caused by face masks can be related to prevailing representations of single-use surgical masks and limited attention paid to environmental concerns.
Possible molecular exploration of herbal pair Haizao-Kunbu in the treatment of Graves’ disease by network pharmacology, molecular docking, and molecular dynamic analysis
Authors: Yang Mengfei , Lai Yiwen , Gan Di , Liu Qingyang , Wang Yingna , He Xinyong , An Yi , Gao Tianshu 
Published: October 2023

ObjectiveTo promote the development and therapeutic application of new medications, it is crucial to conduct a thorough investigation into the mechanism by which the traditional Chinese herb pair of Haizao-Kunbu (HK) treats Graves’ disease (GD).Materials and methodsChemical ingredients of HK, putative target genes, and GD-associated genes were retrieved from online public databases. Using Cytoscape 3.9.1, a compound-gene target network was established to explore the association between prosperous ingredients and targets. STRING, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathway analyses visualized core targets and disease pathways. Additionally, we conducted a refined analysis of the binding interactions between active ingredients and their respective targets. To visualize these findings, we employed precise molecular docking techniques. Furthermore, we carried out molecular dynamics simulations to gain insights into the formation of more tightly bound complexes.ResultsWe found that there were nine key active ingredients in HK, which mainly acted on 21 targets. These targets primarily regulated several biological processes such as cell population proliferation, protein phosphorylation, and regulation of kinase activity, and acted on PI3K-AKT and MAPK pathways to treat GD. Analysis of the molecular interaction simulation under computer technology revealed that the key targets exhibited strong binding activity to active ingredients, and Fucosterol-AKT1 and Isofucosterol-AKT1 complexes were highly stable in humans.ConclusionThis study demonstrates that HK exerts therapeutic effects on GD in a multi-component, multi-target, and multi-pathway manner by regulating cell proliferation, differentiation, inflammation, and immunomodulatory-related targets. This study provides a theoretical foundation for further investigation into GD.
Automated method based on a neural network model for searching energy-efficient complex movement trajectories of industrial robot in a differentiated technological process
Authors: Gorkavyy Mikhail A. , Gorkavyy Aleksandr I. , Egorova Valeria P. , Melnichenko Markel A. 
Published: October 2023

Purpose of the work: Researching possibility of creating a method for improving the energy efficiency of differentiated robotic technological process (RTP) in the food industry. The high rates of development of production processes robotization, including in the food industry, leading to increase the cost of electrical energy, determine the research tasks relevance in finding energy-efficient methods for controlling industrial robots.Methodology: The proposed approach is based on principles of object-oriented design and possibility of classifying robotic technological process: Applying specific model sets and methods to improve energy efficiency to individual classes. The existing possibility of energy consumption synthesizing models of robots inside differentiated robotic technological process, such as stacking loads, in reduced form, made it possible to use neural network methods to identify non-linear dependencies. At the same time, training sample for intelligent modules was formed on the basis of classical experiment planning algorithms. The synthesis of methods, models and procedures was implemented on the basis of high-level programming languages C++, MATLAB.Results: A mathematical model and automated algorithms for its synthesis are proposed, which make it possible to adjust robotic technological process simulation model taking into account its specifics and implement a method for finding the optimal parameters of its functioning. To confirm the effectiveness of proposed solution, the obtained neural network model and optimization method were tested on real robotic technological process, and the calculation of economic efficiency of proposed solution was also given.Conclusion/recommendations: The application of this approach will significantly reduce energy costs for robotic operations in the food industry.
Effect of Danhong injection on heart failure in rats evaluated by metabolomics
Authors: Li Lin , Zhong Senjie , Ye Jiahao , Hu Siyuan , Hu Zhixi 
Published: October 2023

BackgroundHeart failure (HF) is characterized by reduced ventricular filling or ejection function due to organic or non-organic cardiovascular diseases. Danhong injection (DHI) is a medicinal material used clinically to treat HF for many years in China. Although prior research has shown that Danhong injection can improve cardiac function and structure, the biological mechanism has yet to be determined.MethodsSerum metabolic analysis was conducted via ultra-high-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UHPLC-QE/MS) to explore underlying protective mechanisms of DHI in the transverse aortic constriction (TAC)-induced heart failure. Multivariate statistical techniques were used in the research, such as unsupervised principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). MetaboAnalyst and Kyoto Encyclopedia of Genes and Genomes (KEGG) were employed to pinpoint pertinent metabolic pathways.ResultsAfter DHI treatment, cardiac morphology and function as well as the metabolism in model rats were improved. We identified 17 differential metabolites and six metabolic pathways. Two biomarkers, PC(18:3(6Z,9Z,12Z)/24:0) and L-Phenylalanine, were identified for the first time as strong indicators for the significant effect of DHI.ConclusionThis study revealed that DHI could regulate potential biomarkers and correlated metabolic pathway, which highlighted therapeutic potential of DHI in managing HF.
Changing trends of disease burden of stroke from 1990 to 2019 and its predictions among the Chinese population
Authors: Liang Dong , Guan Qing , Huang Minqing , He Yiyu , Ou Yangjiang , Chen Min , Zheng Xiaoxin , Lin Xiuquan 
Published: October 2023

ObjectiveThis study aimed to understand the temporal trends in the disease burden of stroke and its attributable risk factors in China, along with the future trends in the next 25 years, that is important for effective prevention strategies and improvement, and to provide new insights into the age- and sex-specific incidence, prevalence, mortality, disability-adjusted life-years (DALYs) and their trends from 1990 to 2019, and the prediction in the next 25 years.MethodsThe Global Burden of Disease Study (2019) was used to extract the data on age- and sex-specific incidence, mortality, and disability-adjusted life-years (DALYs) of stroke in China, 1990–2019. We estimated the estimated annual percentage change (EAPC) to access the temporal trends of the disease burden of stroke. The R package called Nordpred was used to perform an age-period-cohort analysis to predict the prevalence of stroke.ResultsThe number of incidence cases, deaths, and DALYs of stroke increased from 1990 to 2019. Overall downward trends were observed in the age-standardized incidence rate (ASIR) from 1990 to 2019. Significant temporal trends in mortality and DALYs of stroke were observed. High systolic blood pressure, smoking, and high-sodium diet were the main driving forces for stroke. The DALYs lost attributable to smoking were different for male and female patients. In the next 25 years, the number of new cases and deaths from stroke should continue to increase. The ASIR and age-standardized mortality rate (ASMR) should show a downward trend among male and female patients.ConclusionDespite the overall rates of stroke declined over the period from 1990 to 2019, the absolute number of people affected by stroke has substantially increased. There has been a substantial increase in the burden of stroke due to risk factors and will continue to increase in the next 25 years.
Progression risk stratification with six-minute walk gait speed trajectory in multiple sclerosis
Authors: Goldman Myla D. , Chen Shanshan , Motl Robert , Pearsall Rylan , Oh Unsong , Brenton J. Nicholas 
Published: October 2023

BackgroundMultiple Sclerosis (MS) disease progression has notable heterogeneity among patients and over time. There is no available single method to predict the risk of progression, which represents a significant and unmet need in MS.MethodsMS and healthy control (HC) participants were recruited for a 2-year observational study. A latent-variable growth mixture model (GMM) was applied to cluster baseline 6-min walk gait speed trajectories (6MWGST). MS patients within different 6 MWGST clusters were identified and stratified. The group membership of these MS patients was compared against 2-year confirmed-disease progression (CDP). Clinical and patient-reported outcome (PRO) measures were compared between HC and MS subgroups over 2 years.Results62 MS and 41 HC participants completed the 2-year study. Within the MS cohort, 90% were relapsing MS. Two distinct patterns of baseline 6 MWGST emerged, with one cluster displaying a faster gait speed and a typical “U” shape, and the other showing a slower gait speed and a “flattened” 6 MWGST curve. We stratified MS participants in each cluster as low- and high-risk progressors (LRP and HRP, respectively). When compared against 2-year CDP, our 6 MWGST approach had 71% accuracy and 60% positive predictive value. Compared to the LRP group, those MS participants stratified as HRP (15 out of 62 MS participants), were on average 3.8 years older, had longer MS disease duration and poorer baseline performance on clinical outcomes and PROs scores. Over the subsequent 2 years, only the HRP subgroup showed a significant worsened performance on 6 MW, clinical measures and PROs from baseline.ConclusionBaseline 6 MWGST was useful for stratifying MS participants with high or low risks for progression over the subsequent 2 years. Findings represent the first reported single measure to predict MS disease progression with important potential applications in both clinical trials and care in MS.
Neurocognitive function in children with cochlear implants and hearing aids: a systematic review
Authors: Lima Jefferson Vilela da Silva , de Morais Caroline Favaretto Martins , Zamberlan-Amorim Nelma Ellen , Mandrá Patricia Pupin , Reis Ana Cláudia Mirândola Barbosa 
Published: October 2023

PurposeTo systematically review the existing literature that examines the relationship between cognition, hearing, and language in children using cochlear implants and hearing aids.MethodThe review has been registered in Prospero (Registration: CRD 42020203974). The review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis and examined the scientific literature in VHL, MEDLINE, CINAHL, Scopus, WOS, and Embase. It included original observational studies in children using hearing aids and/or cochlear implants who underwent cognitive and auditory and/or language tests. Data were extracted from the studies and their level of evidence was graded with the Oxford Center for Evidence-Based Medicine: Levels of Evidence. Meta-analysis could not be performed due to data heterogeneity. Outcomes are described in narrative and tables synthesis.ResultsThe systematic search and subsequent full-text evaluation identified 21 studies, conducted in 10 different countries. Altogether, their samples comprised 1,098 individuals, aged 0.16–12.6 years. The studies assessed the following cognitive domains: memory, nonverbal cognition, reasoning, attention, executive functions, language, perceptual-motor function, visuoconstructive ability, processing speed, and phonological processing/phonological memory. Children with hearing loss using cochlear implants and hearing aids scored significantly lower in many cognitive functions than normal hearing (NH) children. Neurocognitive functions were correlated with hearing and language outcomes.ConclusionMany cognitive tools were used to assess cognitive function in children with hearing devices. Results suggest that children with cochlear implants and hearing aids have cognitive deficits; these outcomes are mainly correlated with vocabulary. This study highlights the need to understand children’s cognitive function and increase the knowledge of the relationship between cognition, language, and hearing in children using cochlear implants and hearing aids.
Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation
Authors: Zisiadis Georgios Alkis , Alevyzaki Androniki , Nicola Elene , Rodrigues Carlos F. D. , Blomgren Klas , Osman Ahmed M. 
Published: October 2023

IntroductionCranial irradiation (IR) negatively regulates hippocampal neurogenesis and causes cognitive dysfunctions in cancer survivors, especially in pediatric patients. IR decreases proliferation of neural stem/progenitor cells (NSPC) and consequently diminishes production of new hippocampal neurons. Memantine, an NMDA receptor antagonist, used clinically to improve cognition in patients suffering from Alzheimer’s disease and dementia. In animal models, memantine acts as a potent enhancer of hippocampal neurogenesis. Memantine was recently proposed as an intervention to improve cognitive impairments occurring after radiotherapy and is currently under investigation in a number of clinical trials, including pediatric patients. To date, preclinical studies investigating the mechanisms underpinning how memantine improves cognition after IR remain limited, especially in the young, developing brain. Here, we investigated whether memantine could restore proliferation in the subgranular zone (SGZ) or rescue the reduction in the number of hippocampal young neurons after IR in the juvenile mouse brain.MethodsMice were whole-brain irradiated with 6 Gy on postnatal day 20 (P20) and subjected to acute or long-term treatment with memantine. Proliferation in the SGZ and the number of young neurons were further evaluated after the treatment. We also measured the levels of neurotrophins associated with memantine improved neural plasticity, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).ResultsWe show that acute intraperitoneal treatment with a high, non-clinically used, dose of memantine (50 mg/kg) increased the number of proliferating cells in the intact brain by 72% and prevented 23% of IR-induced decrease in proliferation. Long-term treatment with 10 mg/kg/day of memantine, equivalent to the clinically used dose, did not impact proliferation, neither in the intact brain, nor after IR, but significantly increased the number of young neurons (doublecortin expressing cells) with radial dendrites (29% in sham controls and 156% after IR) and enhanced their dendritic arborization. Finally, we found that long-term treatment with 10 mg/kg/day memantine did not affect the levels of BDNF, but significantly reduced the levels of NGF by 40%.ConclusionThese data suggest that the enhanced dendritic complexity of the hippocampal young neurons after treatment with memantine may contribute to the observed improved cognition in patients treated with cranial radiotherapy.
Association of plasma iron with the risk of incident cancer in Chinese adults with hypertension: a nested case-control study
Authors: Zhu Hehao , Wei Yaping , He Qiangqiang , Song Yun , Liu Lishun , Sun Yong , Zhang Hao , Guo Huiyuan , Xu Xiping , Wang Binyan 
Published: October 2023

BackgroundIron is an essential element for organismal health but excessive iron is potentially toxic. However, few observational studies link plasma iron (PI) concentrations and cancer risk, and the results are inconsistent.ObjectiveThis study aimed to explore the associations of PI concentrations with cancer risk in Chinese adults with hypertension.MethodsWe conducted a nested, case-control study, including 223 pairs of incident cancer cases and matched controls from the China Stroke Primary Prevention Trial. The median time between blood sample collection and subsequent cancer event occurrence was 2.13 years. The odds ratio (OR) and 95% confidence interval (CI) for the risk of cancer by PI were estimated from multivariable conditional logistic regression models.ResultsThere was a nonlinear association between PI concentrations and total cancer risk. When compared with participants in tertile 2 of PI, the ORs of total cancer were 2.17 (95%CI: 1.25-3.85) and 1.29 (95%CI: 0.77-2.19) in participants in PI tertiles 3 and 1, respectively. Furthermore, higher PI was associated with increased digestive system cancer risk (OR=3.25, 95%CI:1.29-8.90), while lower PI was associated with increased risk of non-digestive system cancer (OR=3.32, 95%CI: 1.39-8.71). In a sensitivity analysis, the increases in total cancer risk or digestive system cancer risk were still observed with higher PI after excluding cancer cases occurring within the first year.ConclusionOur results showed an increased risk of cancer related to higher PI or lower PI in Chinese adults with hypertension. Higher iron levels were linked to an increased risk of digestive system cancers, whereas lower iron levels were linked to an increased risk of non-digestive system cancers.
Questionnaire study of application about sentinel lymph node biopsy surgery in locally advanced breast cancer patients who received neoadjuvant chemotherapy
Authors: Lee Eun-Gyeong , Lee Minjung , Jung So-Youn , Han Jai Hong , Kim Seok-Ki , Lee Seeyoun 
Published: October 2023

BackgroundNodal staging from sentinel lymph node (SLN) biopsy has become the standard procedure for early-stage breast cancer patients. SLN biopsy implementation after chemotherapy has previously been evaluated. This questionnaire study aimed to investigate the current trend of SLN biopsy after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer.Methods and materialsWe conducted a web-based survey among breast surgeons who are members of the Korean Breast Cancer Society. The survey comprised 14 questions about axillary surgery after NAC.ResultsOf 135 respondents, 48.1% used a combined method of dye and radioactive isotope (RI). In the absence of SLN metastasis, 67.7% would perform only SLN biopsy, while 3% would perform ALN dissection. In case of SLN metastasis, the proportions of surgeons who would proceed with ALN dissection were 60.2% and 67.2% for less than two and more than three positive SLNs, respectively.ConclusionThe present study confirmed the increasing tendency to adopt SLN biopsy for axillary staging in patients who achieved complete response with initial nodal metastasis. It could be expected that the mapping methods for patients receiving NAC have become diverse, including RI, vital dye, and indocyanine green fluorescence. The implementation of SLN biopsy after NAC will grow in the coming years due to an increasing demand of minimally invasive surgery.
Clinical hypoxemia score for outpatient child pneumonia care lacking pulse oximetry in Africa and South Asia
Authors: Schuh Holly B. , Hooli Shubhada , Ahmed Salahuddin , King Carina , Roy Arunangshu D. , Lufesi Norman , Islam ASMD Ashraful , Mvalo Tisungane , Chowdhury Nabidul H. , Ginsburg Amy Sarah , Colbourn Tim , Checkley William , Baqui Abdullah H. , McCollum Eric D. 
Published: October 2023

BackgroundPulse oximeters are not routinely available in outpatient clinics in low- and middle-income countries. We derived clinical scores to identify hypoxemic child pneumonia.MethodsThis was a retrospective pooled analysis of two outpatient datasets of 3–35 month olds with World Health Organization (WHO)-defined pneumonia in Bangladesh and Malawi. We constructed, internally validated, and compared fit &amp; discrimination of four models predicting SpO2 &lt; 93% and &lt;90%: (1) Integrated Management of Childhood Illness guidelines, (2) WHO-composite guidelines, (3) Independent variable least absolute shrinkage and selection operator (LASSO); (4) Composite variable LASSO.Results12,712 observations were included. The independent and composite LASSO models discriminated moderately (both C-statistic 0.77) between children with a SpO2 &lt; 93% and ≥94%; model predictive capacities remained moderate after adjusting for potential overfitting (C-statistic 0.74 and 0.75). The IMCI and WHO-composite models had poorer discrimination (C-statistic 0.56 and 0.68) and identified 20.6% and 56.8% of SpO2 &lt; 93% cases. The highest score stratum of the independent and composite LASSO models identified 46.7% and 49.0% of SpO2 &lt; 93% cases. Both LASSO models had similar performance for a SpO2 &lt; 90%.ConclusionsIn the absence of pulse oximeters, both LASSO models better identified outpatient hypoxemic pneumonia cases than the WHO guidelines. Score external validation and implementation are needed.
COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination
Authors: Zhang Zeying , Wang Dan , Zuo Wanyun , Wang Xun , Yang Fan , Luo Haiyan , Xiao Zhenghui , Liu Qiming , Xiao Yunbin 
Published: October 2023

ObjectiveTo determine the reasons why pulmonary hypertension (PH) children refused vaccination against COVID-19, evaluate the safety and efficacy of COVID-19 vaccine in PH children.Study designThis retrospective cohort study included congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) and bronchopulmonary dysplasia associated PH (BPD-PH) children who were divided into vaccinated group and non-vaccinated group. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the reasons why PH children refused COVID-19 vaccine. Then, the prevalence, the number of symptoms, and the severity of COVID-19 disease were compared between the vaccinated and unvaccinated groups.ResultWe included 73 children and 61 children (83.6%) were unvaccinated. The main reasons for not being vaccinated were fear of worsening of existing diseases (31%). Age &lt; 36 months (RR: 0.012; P &lt; 0.001) and the presence of comorbidities (RR = 0.06; P = 0.023) were risk factors influencing willingness to vaccinate. The most common adverse events (AEs) were injection site pain (29.6%). COVID-19 vaccines are safe for PH children. The prevalence of COVID-19 disease decreased in PH children after vaccination (RR = 0.51; P = 0.009). 1 month after negative nucleic acid test or negative antigen test, PH children in the vaccinated group had fewer symptoms (P = 0.049).ConclusionsThe vaccination rate of COVID-19 vaccine is low in CHD-PAH and BPD-PH children while COVID-19 vaccines are safe. Vaccination can reduce the prevalence of COVID-19 disease and the number of symptoms 1 month after negative nucleic acid or antigen tests.