bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Anal Neoplasia Society's consensus guidelines for anal cancer screening
Authors: Stier Elizabeth A. , Clarke Megan A. , Deshmukh Ashish A. , Wentzensen Nicolas , Liu Yuxin , Poynten I. Mary , Cavallari Eugenio Nelson , Fink Valeria , Barroso Luis F. , Clifford Gary M. , Cuming Tamzin , Goldstone Stephen E. , Hillman Richard J. , Rosa‐Cunha Isabela , La Rosa Luciana , Palefsky Joel M. , Plotzker Rosalyn , Roberts Jennifer M. , Jay Naomi 
Published: February 2024

AbstractThe International Anal Neoplasia Society (IANS) developed consensus guidelines to inform anal cancer screening use among various high‐risk groups. Anal cancer incidence estimates by age among risk groups provided the basis to identify risk thresholds to recommend screening. Guided by risk thresholds, screening initiation at age 35 years was recommended for men who have sex with men (MSM) and transgender women (TW) with HIV. For other people with HIV and MSM and TW not with HIV, screening initiation at age 45 years was recommended. For solid organ transplant recipients, screening initiation beginning from 10 years post‐transplant was recommended. For persons with a history of vulvar precancer or cancer, screening initiation was recommended starting within 1 year of diagnosis of vulvar precancer or cancer. Persons aged ≥45 years with a history of cervical/vaginal HSIL or cancer, perianal warts, persistent (>1 year) cervical HPV16, or autoimmune conditions could be considered for screening with shared decision‐making, provided there is adequate capacity to perform diagnostic procedures (high‐resolution anoscopy [HRA]). Anal cytology, high‐risk (hr) human papillomavirus (HPV) testing (including genotyping for HPV16), and hrHPV‐cytology co‐testing are different strategies currently used for anal cancer screening that show acceptable performance. Thresholds for referral for HRA or follow‐up screening tests are delineated. These recommendations from IANS provide the basis to inform management of abnormal screening results, considering currently available screening tools. These guidelines provide a pivotal foundation to help generate consensus among providers and inform the introduction and implementation of risk‐targeted screening for anal cancer prevention.
A review of the concurrent‐chains arrangement to assess intervention choice: 2018–2023
Authors: Auten Emma M. , Van Camp Carole , Ferguson Allie B. 
Published: February 2024

AbstractThe purpose of this review is to summarize recent literature on the use of concurrent‐chains arrangements in the assessment of preference for interventions (or intervention components) in the applied literature. The types of interventions and participants are described briefly, and procedural variations, ethical considerations, and recommendations for future research are discussed.
The sexual and reproductive health covariates of early menarche among adolescent girls
Authors: Ibitoye Mobolaji , Sandfort Theo G. M. , Bingenheimer Jeffrey B. , Sommer Marni 
Published: February 2024

AbstractIntroductionResearch suggests that girls who reach menarche at an early age are at greater risk for negative sexual and reproductive health (SRH) outcomes than their later‐maturing counterparts, but very little research has examined this issue in sub‐Saharan Africa, especially in West Africa. The goal of the current study was to determine whether early menarche was associated with any SRH outcomes in a sample of Ghanaian girls.MethodsThe study data were drawn from the baseline assessment of a longitudinal study involving two age cohorts (13–14 and 18–19 years) of 700 adolescent girls from Ghana. Logistic regressions were used to assess the association between early menarche (before age 13) and seven SRH outcomes (adolescent sexual activity, early sexual initiation, inconsistent condom use, transactional sex, sexual violence, multiple sexual partners, and adolescent pregnancy).ResultsEarly menarche was significantly associated with adolescent sexual activity (odds ratio [OR] = 6.4; 95% confidence interval [CI] 2.1–19.7), and sexual violence (OR = 3.2; 95% CI 1.6–6.2) in the younger cohort and early sexual initiation (OR = 3.2; 95% CI 1.19–8.61) and multiple sexual partners (OR = 3.7; 95% CI 1.39–9.87) in the older cohort. Early menarche was also associated with transactional sex and teen pregnancy in the full sample.ConclusionsThese findings suggest the need for special attention to the needs of early‐maturing girls in SRH programming. Interventions are needed to delay adolescent sexual activity in girls with early menarche. Efforts to prevent sexual violence among adolescent girls in Ghana may benefit from targeting and addressing the specific needs of early‐maturing girls.
Hyperspectral upgrade solution for biomicroscope combined withTransformernetwork to classify infectious bacteria
Authors: Lu You , Zhang Lan , Wang Jihong , Bian Lifeng , Ding Zhao , Yang Chen 
Published: February 2024

AbstractInfectious diseases caused by bacterial pathogens pose a significant public health threat, emphasizing the need for swift and accurate bacterial species detection methods. Hyperspectral microscopic imaging (HMI) offers nondestructive, rapid, and data‐rich advantages, making it a promising tool for microbial detection. In this research, we present a highly compatible and cost‐effective approach to extend a standard biomicroscope system into a hyperspectral biomicroscope using a prism‐grating‐prism configuration. Using this prototype, we generate 600 hyperspectral data cubes forListeria,Bacillus typhi,Bacillus pestis, andBacillus anthracis. Additionally, we propose a Transformer‐based classification network that achieves a 99.44% accuracy in classifying these infectious pathogens, outperforming traditional methods. Our results suggest that the successful combination of HMI and the optimized Transformer‐based classification network highlights the potential for rapid and precise detection of infectious disease pathogens.
Copper‐doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention
Authors: El‐Sayed Sara A. M. , ElShebiney Shaimaa , Beherei Hanan H. , Kumar Pradeep , Choonara Yahya E. , Mabrouk Mostafa 
Published: February 2024

AbstractCalvarial defects of bone present difficult clinical situations, and their restoration using biocompatible materials requires special treatments that enable bone regeneration. Magnesium phosphate (MgP) is known as an osteoinductive biomaterial because it contains Mg2+ ions and P ions that enhance the activity of osteoplast cells and help in bone regeneration. In this study, MgP and CuO‐doped MgP were fabricated and characterized for their physicomechanical properties, particle size, morphology, surface area, antibacterial test, and in vitro bioactivity evaluation using the following techniques: X‐rays diffraction, Fourier‐transformer infrared, TEM, and Brunauer, Emmett and Teller (BET) surface area, X‐rays photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM). Furthermore, these nanopowders were implanted in adult inbred male Wistar rats and studied after two periods (28 and 56 days). The results demonstrated that the obtained semiamorphous powders are in nanoscale (≤ 50 nm). XPS analysis ensured the preparation of MgP as mono MgP and CuO were incorporated in the structure as Cu2+. The bioactivity was supported by the observation of calcium phosphate layer on the nanopowders' surface. The in vivo study demonstrated success of MgP nanopowders especially those doped with CuO in restoration of calvarial defect bone. Therefore, fabricated biomaterials are of great potential in restoration of bone calvarial defects.
Development and validation of a self‐report measure of perceived dehumanization from officers
Authors: Robison Morgan , Baker Thomas , Abderhalden Frances P. , Gordon Jill A. , Joiner Thomas E. 
Published: February 2024

AbstractPurposeEmerging evidence indicates that incarcerated populations' perceptions of dehumanization by officers are prevalent, yet measures of it are few, and to our knowledge, no self‐report measure of dehumanization from officers exists. To fill this gap, we have developed the Perceived Dehumanization from Officers Scale (PDOS), which is designed as a brief measure to assess perception of officer treatment as dehumanizing.MethodsIn this article, we provide preliminary evidence from two studies examining the reliability and validity of the PDOS. In study 1, a jail sample (n = 411), we analyzed the exploratory factor structure, internal consistency, and discriminant validity (in relation to procedural justice [PJ]) of the PDOS. Additionally, using a cross‐sectional ordinary least squares (OLS) regression analysis, we related independent variables with the PDOS, the dependent variable. In Study 2, a prison sample (n = 2993), we confirmed the findings from study 1.ResultsThe PDOS appears to be a psychometrically sound measure of perceived dehumanization from officers with strong association between perceptions of PJ and perceived dehumanization from officers.ConclusionsThe PDOS provides opportunity for future research, intervention through rehumanization efforts, and signals the important officer treatment. Importantly We close by discussing implications of these studies, limitations, and future research directions to further develop and test the PDOS.
Statin Drug‐Drug Interactions: Pharmacokinetic Basis of FDA Labeling Recommendations and Comparison Across Common Tertiary Clinical Resources
Authors: Mease James , Ramamoorthy Anuradha , Yang Xinning , Madabushi Rajanikanth , Pfuma Fletcher Elimika , Zineh Issam 
Published: February 2024

AbstractStatins are widely prescribed and highly susceptible to pharmacokinetic (PK)‐based drug–drug interactions (DDIs). To date, there has not been a comprehensive analysis of the basis upon which statin DDI recommendations in US Food and Drug Administration (FDA) prescribing information (PI) are derived. We have conducted such an analysis. We also assessed the degree of concordance of statin DDI recommendations in FDA PI and those provided in common tertiary clinical resources. We catalogued statin DDI information, including PK data and management recommendations, for statin precipitant drugs approved from 2010 to 2021, available from FDA PI and tertiary clinical resource databases. Recommendations were categorized and mapped with associated PK data to assess consistency in the PK basis for labeling recommendations. From the 80 precipitant drugs evaluated, 180 statin DDIs were identified in FDA PI. Dedicated clinical DDI studies were conducted for 54% (n = 97) of these DDIs and 34% (n = 61) of DDI recommendations were extrapolated from clinical data with other statins. Overall, we found that PK‐based statin recommendations were consistent across PI. These findings highlight regulatory precedence for translating information across statins without conducting dedicated clinical DDI studies, which may support future efforts toward streamlining the approach to investigation and labeling of statin DDIs. In addition, with the exception of some notable discrepancies, general concordance was observed between FDA and tertiary resources regarding “Dose Adjustment” and “Avoid Coadministration” recommendations. However, further analyses are warranted across other DDI pairs to determine whether discordance can routinely lead to different clinical recommendations depending on the drug information resource.
ISG15 mediates the function of extracellular vesicles in promoting ovarian cancer progression and metastasis
Authors: Dorayappan Kalpana Deepa Priya , Wagner Vincent , Park Dongju , Newcomer Meghan M. , Lightfoot Michelle D. S. , Kalaiyarasan Deepika , Sakaue Takahiko , Khadraoui Wafa , Yu Lianbo , Wang Qi‐En , Maxwell G. Larry , O'Malley David , Pollock Raphael E. , Cohn David E. , Selvendiran Karuppaiyah 
Published: February 2024

AbstractThe interferon stimulated gene 15 (ISG15), a ubiquitin like protein and its conjugates have been implicated in various human malignancies. However, its role in ovarian cancer progression and metastasis is largely unknown. In high grade serous ovarian cancer (HGSOC), ascites is the major contributor to peritoneal metastasis. In this study, we identified significantly elevated ISG15 protein expression in HGSOC patient ascites, ascites derived primary ovarian cancer cells (POCCs), POCC small extracellular vesicles (sEVs) as well as metastatic tissue. Our results demonstrates that ISG15 increases exocytosis in ascites‐derived POCCs by decreasing the endosome‐lysosomal fusion, indicating a key role in sEV secretion. Further, knockdown (KD) of ISG15 resulted in a significant decrease in vesicles secretion from HGSOC cells and in vivo mouse models, leading to reduced HGSOC cell migration and invasion. Furthermore, our pre‐clinical mouse model studies revealed the influence of vesicular ISG15 on disease progression and metastasis. In addition, knockdown of ISG15 or using the ISG15 inhibitor, DAP5, in combination therapy with carboplatin showed to improve the platinum sensitivity in‐vitro and reduce tumour burden in‐vivo. We also found that ISG15 expression within sEV represents a promising prognostic marker for HGSOC patients. Our findings suggest that ISG15 is a potential therapeutic target for inhibiting progression and metastasis in HGSOC and that vesicular ISG15 expression could be a promising biomarker in the clinical management of ovarian cancer.Significance: High‐grade serous ovarian cancer (HGSOC) has high morbidity and mortality rates, but its progression and metastasis are still poorly understood, and there is an urgent need for early detection and targeted therapies. Our study presents novel findings that implicate ISG15‐mediated vesicular proteins in the advancement and spread of HGSOC. These results offer pre‐clinical evidence of potential new molecular targets, prognostic markers and therapeutic strategies for HGSOC that could ultimately enhance patient survival.
Tissue markers may predict treatment response to antitumor necrosis factor‐α agents in children with Crohn's disease
Authors: Krauthammer Alexander , Cozacov Tal , Fried Sophia , Har‐Zahav Adi , Shamir Raanan , Assa Amit , Waisbourd‐Zinman Orith 
Published: February 2024

AbstractObjectivesPatients with moderate‐severe Crohn's disease (CD) who are treated with antitumor necrosis factor alpha (TNF‐α) agents may be subjected to primary nonresponse or partial response. We aimed to identify tissue markers that may predict response to these agents.MethodsPediatric patients (6–18 years) with either ileal or ileo‐colonic CD who were treated with anti‐TNF‐α were stratified into three different groups based on their overall response to therapy at the end of induction including clinical and laboratory parameters (group 1—full responders [FR], group 2—partial responders [PR], group 3—nonresponders [NR]). Seven tissue markers (fibronectin, interleukin [IL]‐23R, IL‐23, TNF‐α, collagen‐III, IL‐13R, and hypoxia‐inducible factors [HIF]‐1α) were evaluated. Immunofluorescence (IF) analyses were performed on biopsies from the terminal ileum, which were retrieved up to 6 months before treatment initiation.ResultsTwenty‐six CD patients (16 [61.5%] males; age 13.9 ± 2.9 years), including 8 (30.8%) with ileal disease and 18 (69.2%) with ileo‐colonic disease, were enrolled. Terminal ileum biopsies from nine patients from group 1, nine from group 2, and eight from group 3 were evaluated. Three antibodies were found to be significantly different between NR and FR groups; Collagen III and fibronectin stains were significantly more prominent in NR patients, while TNF‐α stain was significantly more pronounced in FR, p < 0.05 for each. PR could not have been predicted with neither of markers.ConclusionsDecreased tissue IF intensity of fibronectin and collagen III and increased intensity of TNF‐α may predict response to anti‐TNF‐α treatment.
A lipidomics approach reveals novel phospholipid changes in palmitate‐treated C2C12 myotubes
Authors: Tawara Wakako , Morisasa Mizuki , Mukai Risa , Suo Rei , Itoi Shiro , Mori Tsukasa , Goto‐Inoue Naoko 
Published: February 2024

AbstractType 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder. Insulin resistance and oxidative stress are associated with T2DM development. The hypothesis that patients with T2DM show excess accumulation of lipids, such as ceramides (Cers) and diacylglycerols (DAGs), in their skeletal muscles has been widely supported; however, detailed lipidomic data at the molecular species level are limited. Therefore, in this study, we aimed to investigate the in vitro dynamics of total lipids, including phospholipids (PLs), sphingolipids, and neutral lipids, in palmitic acid‐induced insulin‐resistant C2C12 skeletal muscle cells. Our data demonstrated that the profiles of not only Cers and DAGs but also those of PLs showed considerably differences after palmitate treatment. We found that PL synthesis reduced and PL degradation increased after palmitate treatment. These findings may aid in the development of treatments to ameliorate muscle dysfunction caused by lipid accumulation in muscles.
Assessment of x‐ray efficacy for intraoperative microneedle retrieval using a cadaveric model
Authors: Chaker Sara C. , Hung Ya‐Ching , Vinson Ariel A. , Saad Mariam , Perdikis Galen , Laxminarayan Bhandari Panambur 
Published: February 2024

AbstractIntroductionInstitutional protocols often mandate the use of x‐rays when a microneedle is lost intraoperatively. Although x‐rays can reliably show a macroneedle, the benefit of x‐rays in detecting microneedles in human tissues has not been established as available data on this topic are investigated in anthropometric models. The current study aims to evaluate whether x‐rays can reliably detect retained microneedles in a human cadaveric model. We hypothesize that microneedles would be detected at a significantly lower rate than macroneedles by x‐ray in human tissues.Materials and MethodsNeedles ranging from 4‐0 to 10‐0 were placed randomly throughout a cadaveric hand and foot. Each tissue sample was x‐rayed using a Fexitron X‐Ray machine, taking both anteroposterior and lateral views. A total of six x‐ray images were then evaluated by 11 radiologists, independently. The radiologists circled over the area where they visualized a needle. The accuracy of detecting macroneedles (size 4‐0 to 7‐0) was compared with that of microneedles (size 8‐0 to 10‐0) using a chi‐square test.ResultsThe overall detection rate for the microneedles was significantly lower than the detection rate for macroneedles (13.5% vs 88.8%, p < .01). When subcategorized between the hand and the foot, the detection rate for microneedles was also significantly lower than the rate for macroneedles (hand: 7.6% for microneedles, 93.2% for macroneedles, p < .01; foot: 19.5% for microneedles, 84.4% for macroneedles, p < .01). The detection rate, in general, significantly decreased as the sizes of needles became smaller (7‐0:70.5%, 8‐0:18.2%, 9‐0:16.7%, 10‐0:2.3%, p < .01).ConclusionX‐rays, while useful in detecting macroneedles, had a significantly lower rate of detecting microneedles in a cadaveric model. The routine use of x‐rays for a lost microneedle may not be beneficial. Further investigation with fresh tissue and similar intraoperative x‐ray systems is warranted to corroborate and support these findings.
The cross‐leg free flap: A systematic review of the literature
Authors: Celie Karel‐Bart , Guo Sarah , Raya Jessica , Fahradyan Artur , Carey Joseph , Salibian Ara A. 
Published: February 2024

AbstractBackgroundFree tissue transfer is a mainstay treatment for lower extremity soft tissue injuries. When the traditional cross‐leg flap cannot provide enough coverage, a cross‐leg free flap (CLFF) is a limb‐saving alternative. The aim of this study is to conduct a systematic review of the literature published on the CLFF.MethodsWe conducted a systematic review of articles describing the CLFF, according to Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. Inclusion criteria included articles with primary data on the CLFF. Exclusion criteria included those describing pedicled cross‐leg flaps or lacking complete data. Data analysis was performed using SPSS 29.0.ResultsOur review included 28 articles encompassing 130 patients who underwent free tissue transfer. Most were male (63.8%) with a mean age of 32.4 years. Latissimus dorsi was the most common flap type (30.0%), followed by vertical rectus myocutaneous (20.0%). Average flap size was 301.8 cm2, with trauma in the lower third of the leg being the most common indication (73.1%). The contralateral posterior tibialis was the most common recipient artery (84.1%) followed by the anterior tibialis (9.5%). Complications included amputation (1.4%), partial graft loss, thrombosis, hematoma, prolonged pain, nonunion, and seroma; a forest plot was used to illustrate the low overall adverse events rate. Although bivariate analysis identified age, flap size, type, location, and donor site as variables significantly impacting the incidence of complications (p < .05), this was not sustained in a multivariate logistic regression model.ConclusionThe CLFF remains an excellent option for limb salvage when a suitable recipient vessel is unavailable. Our review demonstrates 1.4% flap failure and an acceptable complication rate. While most cases in our review describe muscle flaps, we report a complex case of limb salvage using an unusually large anterolateral thigh flap.
Piezoelectric fluorinated polymer composites: A review on coupling agents at the filler/matrix interface
Authors: Bouad Vincent , Girardot Mélanie , Ladmiral Vincent , Barrau Sophie 
Published: February 2024

AbstractAmong electroactive polymers, polyvinylidene fluorine (PVDF) and its copolymers present the highest piezoelectric response which makes them very attractive for applications combining flexibility and piezoelectricity. The use of composites with the incorporation of electroactive ceramics (with a very high piezoelectric coefficient compared to polymers) into the fluorinated polymer matrix allows for an increase in the material piezoelectric response while keeping ductility. The review presents in the first part an overview of the impact of the ceramic particle size and dimension and the filler content. In ceramic/polymer composites, the interface between both constituents is generally weak and has to be strengthened. This review summarizes in the second part different strategies used to improve the interface between the electroactive fillers and the piezoelectric fluorinated polymer matrix to increase the piezoelectric performance of composites. Molecular coupling agents (CAs) are presented and polymer‐based CAs synthesized from “grafting to” and “grafting from” techniques are described. In the last part, the combination of antiparallel poling of ceramic and polymer piezoelectric responses is reported in the composites and the potential of such materials for future development is finally discussed.HighlightsPiezoelectric properties of composites with electroactive ceramic fillers in fluorinated polymer matrix are discussed.Different strategies used to improve the interface between electroactive fillers and piezoelectric fluorinated polymer matrix are presented.The synthesis of molecular CAs or polymer‐based CAs from “grafting to” or “grafting from” techniques is described.The piezoelectric response of ceramic/polymer composites poled in parallel and anti‐parallel are summarized.The antiparallel poling of electroactive ceramic and piezoelectric polymer contributions is a promising way to maximize piezoelectric performances.