bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docetaxel Followed by Hormone Therapy in Men Experiencing Increasing Prostate-Specific Antigen After Primary Local Treatments for Prostate Cancer
Authors: Hussain Arif , Dawson Nancy , Amin Pradip , Engstrom Christine , Dorsey Brenda , Siegel Eliot , Guo Chuanfa 
Published: April 2005

Purpose Prostatectomy or radiation for localized prostate cancer (PC) can fail in up to 15% to 30% of patients. The purpose of this study was to determine feasibility, tolerability, and outcome of docetaxel followed by hormone therapy in men experiencing an increasing prostate-specific antigen (PSA) after their primary local treatments for PC. Patients and Methods Men with increasing serum PSA after prostatectomy or/and radiation were eligible. Serum PSA had to be ≥ 4 ng/mL and serum testosterone had to be in the noncastrate range. Treatment included docetaxel 70 mg/m2 every 3 weeks for up to six cycles, followed by total androgen suppression (luteinizing hormone-releasing hormone agonist plus bicalutamide) and peripheral androgen blockade (finasteride plus bicalutamide) for 12 to 20 months. Results Thirty-nine men were enrolled; 32 had PSA-only failure, seven also had clinical metastasis. Baseline median PSA was 13.7 ng/mL. Serum PSA decreased ≥ 50% in 17 of 35 patients (48.5%) and ≥ 75% in seven of 35 patients (20%) with docetaxel. The PSA decreased to a median of 0.1 ng/mL with subsequent hormone therapy. In 28 of 33 patients the PSA increased (median, 0.41 ng/mL) at a median follow-up of 2.3 months after treatment. In contrast, in five of 33 men the PSA remains at 0.1 ng/mL at a median of 18.9 months after therapy; three of these five men had soft tissue metastasis at entry but remain in complete remission. The most common grade 3 to 4 toxicity was neutropenia (61.5%). Conclusion Docetaxel followed by hormone therapy of limited duration may provide disease control in subgroups of men experiencing failure after local treatments for PC.
Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate in Patients With Endocrine Gastroenteropancreatic Tumors
Authors: Kwekkeboom Dik J. , Teunissen Jaap J. , Bakker Willem H. , Kooij Peter P. , de Herder Wouter W. , Feelders Richard A. , van Eijck Casper H. , Esser Jan-Paul , Kam Boen L. , Krenning Eric P. 
Published: April 2005

Purpose There are few treatment options for patients with metastasized or inoperable endocrine gastroenteropancreatic (GEP) tumors. Chemotherapy can be effective, but the response is usually less than 1 year. Here, we present the results of treatment with a radiolabeled somatostatin analog, [177Lu-DOTA0,Tyr3]octreotate (177Lu-octreotate). Patients and Methods One hundred thirty-one patients with somatostatin receptor-positive tumors were treated with up to a cumulative dose of 600 to 800 mCi (22.2 to 29.6 GBq) of 177Lu-octreotate. Results One patient developed renal insufficiency, and another patient developed hepatorenal syndrome. Creatinine clearance did not change significantly in the other patients. WHO hematologic toxicity grade 3 or 4 occurred after less than 2% of the administrations. We observed complete remission in three patients (2%), partial remission in 32 patients (26%), minor response (tumor diameter decrease of 25% to 50%) in 24 patients (19%), stable disease (SD) in 44 patients (35%), and progressive disease (PD) in 22 patients (18%). Higher remission rates were positively correlated with high uptake on pretherapy somatostatin receptor imaging and a limited number of liver metastases, whereas PD was significantly more frequent in patients with a low performance score and extensive disease. Median time to progression in 103 patients who either had SD or tumor regression was more than 36 months. Conclusion Treatment with 177Lu-octreotate results in tumor remission in a high percentage of patients with GEP tumors. Serious side effects are rare. The median time to progression compares favorably with chemotherapy. Results are better in patients with a limited tumor load. Therefore, early treatment, even in patients who have no PD, may be better.
Chronic Progressive Cardiac Dysfunction Years After Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia
Authors: Lipshultz Steven E. , Lipsitz Stuart R. , Sallan Stephen E. , Dalton Virginia M. , Mone Suzanne M. , Gelber Richard D. , Colan Steven D. 
Published: April 2005

Purpose Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare. Methods Serial echocardiograms (N = 499) were obtained from 115 doxorubicin-treated long-term survivors of childhood acute lymphoblastic leukemia (median age at diagnosis, 4.8 years; median follow-up after completion of doxorubicin, 11.8 years). Results were expressed as z scores to indicate the number of standard deviations (SDs) above (+) or below (−) the normal predicted value. Median individual and cumulative doxorubicin doses were 30 mg/m2 per dose and 352 mg/m2, respectively. Results Left ventricular fractional shortening was significantly reduced after doxorubicin therapy, and the reduction was related to cumulative dose. z scores for fractional shortening transiently improved before falling to −2.76 more than 12 years after diagnosis. Reduced fractional shortening was related to impaired contractility and increasing afterload, consequences of a progressive reduction of ventricular mass, and wall thickness relative to body-surface area. Left ventricular contractility fell significantly over time and was depressed at last follow-up in patients receiving more than 300 mg/m2 of doxorubicin. Systolic and diastolic blood pressures were below normal more than 9 years after diagnosis. Even patients receiving lower cumulative doxorubicin doses experienced reduced mass and dimension. Fractional shortening and dimension at the end of therapy predicted these parameters 11.8 years later. Conclusion Cardiac abnormalities were persistent and progressive after doxorubicin therapy. Inadequate ventricular mass with chronic afterload excess was associated with progressive contractile deficit and possibly reduced cardiac output and restrictive cardiomyopathy. The deficits were worst after highest cumulative doses of doxorubicin, but appeared even after low doses.
Direct Evidence of Ion-dipole Interaction between Imidazolium Cations and Polar Molecules in Ionic Liquid Solutions by Means of Mass Spectrometric Analysis of Clusters
Authors: Kanakubo Mitsuhiro , Hiejima Yusuke , Aizawa Takafumi , Kurata Yoshiaki , Wakisaka Akihiro 
Published: April 2005

Abstract
The mass spectrometric analyses of clusters in solutions composed of hydrophobic 1-alkyl-3-methylimidazolium hexafluorophosphates and various polar organic solvents demonstrate that the Coulomb-dipole interaction between the imidazolium cations and polar molecules is relatively strong.
Recognizing Nano SnO as an Electrode Material for Electrochemical Double Layer Capacitors
Authors: Rao M Mohan , Jayalaksmi M , Reddy B Ramachandra , Madhavendra S S , Kantam M Lakshmi 
Published: April 2005

Abstract
In this communication, we recognize the electrochemical capacitance behavior of SnO (tin(II) oxide) nanoparticles in aqueous solutions. TEM image shows the SnO nanoparticles synthesized via hydrothermal method to be in the nano scale range. The nanomaterial was immobilized on paraffin-impregnated graphite electrode to preserve the high surface area of SnO nanoparticles which plays a crucial role in preserving the electrochemical activity. In 0.1 M NaCl solutions, nano SnO provided a high cell voltage of 1.65 V vs Ag/AgCl and the nanomaterial was chemically and electrochemically stable over 1000 cycles of potentiodynamic and charge–discharge measurements.
New Triggering System for Dioxetane-based Chemiluminescence: Base-induced Decomposition of Bicyclic Dioxetanes Bearing a 3-Aminophenyl or 2-Phenylindol-6-yl Moiety
Authors: Watanabe Nobuko , Ichikawa Miho , Ono Ayumi , Murakami Hiroyuki , Matsumoto Masakatsu 
Published: April 2005

Abstract
A dioxetane substituted with a 3-aminophenyl group was deprotonated with t-BuOK in DMSO to give an unstable dioxetane bearing a phenylamide anion, which decomposed with accompanying emission of flash red light. Dioxetane bearing an indol-6-yl group was synthesized and found to exhibit emission of flash blue light on treatment with tetrabutylammonium fluoride as well as with t-BuOK.
Asymmetric 1,4-Addition of Potassium Aryltrifluoroborates [ArBF3]K to Enones Catalyzed by Dicationic Palladium(II) Complexes
Authors: Nishikata Takashi , Yamamoto Yasunori , Miyaura Norio 
Published: April 2005

Abstract
Asymmetric 1,4-addition of [ArBF3]K to cyclic and acyclic enones was carried out in aqueous methanol in the presence of a chiral phosphine-dicationic palladium(II) catalyst. A palladium complex of (S,S)-dipamp gave optically active β-arylketones of up to 96 % ee for 2-cyclohexenone and 2-cycloheptenone. A palladium-(S,S)-chiraphos complex resulted in 82–97 % ee for 2-cyclopentenone and acyclic enones.
Precession of Silver Dendrites in a Magnetic Field Due to MHD Induced Convection
Authors: Katsuki Akio , Tanimoto Yoshifumi 
Published: April 2005

Abstract
The “in situ” observation of the growth of dendrites was carried out in the superconducting magnet. The small dendrites showed the precession in the magnetic field. The precession was caused by Lorentz force on silver ions, and the boundary condition promoted the motion. The boundary-assisted MHD is main mechanism of the precession.
Potassium Fluoride-induced 1,4-Elimination of o-[(Trimethylsilyl)methyl]benzyl Acetates: A Versatile Generation of o-Quinodimethanes
Authors: Kuwano Ryoichi , Shige Takenori 
Published: April 2005

Abstract
o-Quinodimethane interemediate was generated from o-[(trimethylsilyl)methyl]benzyl acetate with potassium fluoride. The o-quinodimethane in hand reacted with electron-deficient olefins, affording [4+2] cycloadducts, tetrahydronaphthalenes.
A Case History in Fishing Regulations in Great Smoky Mountains National Park: 1934–2004
Authors: Kulp Matt A. , Moore Stephen E. 
Published: April 2005

Abstract
Since the establishment of Great Smoky Mountains National Park (GRSM) in 1934, fisheries managers have utilized about every angling regulation in the toolbox to manage salmonids. Our objectives here were to summarize the regulation history of GRSM and determine whether regulations affected the age or size structure, growth, and population dynamics of wild populations of rainbow trout Oncorhynchus mykiss within GRSM. Data inconsistencies made data comparisons among regulation periods difficult; however, where feasible, comparisons revealed similar population dynamics among periods. The number of legal rainbow trout per kilometer of stream ranged from 215 to 885 throughout the 70-year study period, regardless of regulation. There were no statistical differences in rainbow trout relative stock densities (RSDs) on Little River among the 1930s, 1950s, 1980s, and 1990s, despite liberal regulations prior to 1960. Rainbow trout mean length at age data indicate no differences among populations for age-1 to age-4 rainbow trout. There also was no statistical difference between the age structure data for age-1 to age-4 rainbow trout collected in 1945 and 1993. Water quality data indicate that GRSM streams are naturally acidic and infertile, which results in populations that exhibit fast growth with high annual mortality rates. As a result, we determined that regulations provided no discernable effect on wild rainbow trout populations in GRSM. Most regulations were put in place for social reasons and were never evaluated over long-term periods (&gt;5 years). Abiotic events, such as droughts and floods, have a much greater effect on salmonid abundance in GRSM than do regulations or fishing pressure.
Gene delivery to embryonic stem cells
Authors: Kobayashi Naoya , Rivas‐Carrillo Jorge David , Soto‐Gutierrez Alejandro , Fukazawa Takuya , Chen Yong , Navarro‐Alvarez Nalu , Tanaka Noriaki 
Published: April 2005

AbstractSince the establishment of embryonic stem (ES) cells and the identification of tissue‐specific stem cells, researchers have made great strides in the analysis of the natural biology of such stem cells for the development of therapeutic applications. Specifically, ES cells are capable of differentiating into all of the cell types that constitute the whole body. Thus, ES cell research promises new type of treatments and possible cures for a variety of debilitating diseases and injuries. The potential medical benefits obtained from stem cell technology are compelling and stem cell research sees a bright future. Control of the growth and differentiation of stem cells is a critical tool in the fields of regenerative medicine, tissue engineering, drug discovery, and toxicity testing. Toward such a goal, we present here an overview of gene delivery in ES cells, covering the following topics: significance of gene delivery in ES cells, stable versus transient gene delivery, cytotoxicity, suspension versus adherent cells, expertise, time, cost, viral vectors for gene transduction (lentiviruses, adenoviruses, and adeno‐associated viruses, chemical methods for gene delivery, and mechanical or physical gene delivery methods (electroporation. nucleofection, microinjection, and nuclear transfer). Birth Defects Research (Part C) 75:10–18, 2005. © 2005 Wiley‐Liss, Inc.
Effects of segment substitution on the structure and stability of immunoglobulin G binding domain of streptococcal protein G
Authors: Du Hai‐Ning , Zhang Tie‐Ying , Chang Yong‐Gang , Lin Dong‐Hai , Hu Hong‐Yu 
Published: April 2005

AbstractStructural formation of segments plays pivotal roles in protein folding and stability, but how the segment influences the structural ensemble remains elusive. We engineered two hybrid proteins by replacing the central helical segment of immunoglobulin G binding domain of streptococcal protein G with an α‐helix or β2‐strand element of a structural homologue, the immunoglobulin G binding domain of streptococcal protein L. The results show that substitution by the α‐helical sequence retains a folded structure predominantly with a three‐stranded β‐sheet but slightly destabilizes the compact ensemble, while substitution by the β2‐strand sequence completely destroys the structural formation. The finding implies that the local segment may influence the tertiary structure and overall stability, and the tertiary interactions may modulate structural formation of the segment, which might be considered when studying protein folding, prediction, design, and engineering. © 2005 Wiley Periodicals, Inc. Biopolymers 79: 9–17, 2005This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Discrete-choice experiment to measure patient preferences for the surgical management of colorectal cancer
Authors: Salkeld G , Solomon M , Butow P , Short L 
Published: April 2005

Abstract

Background
Establishing trust between a patient and his or her surgeon is of paramount importance. The aim of this study was to assess the relative importance of the ‘attributes of trust’ between surgeon and patient with colorectal cancer.

Methods
A discrete-choice questionnaire was conducted with 60 men and 43 women who had completed primary treatment for colorectal cancer in two teaching hospitals in Sydney, Australia.

Results
Forty-seven of the 103 patients based their choice of surgical management on a single attribute and the remainder were willing to trade between different attributes. In order of importance, patients based their choice of surgical management on specialty training (β coefficient = 0·83), surgeon's communication (β = 0·82), type of hospital (β = 0·72) and who decides treatment (β = 0·01). Patients who were vigilant in their decision-making style and those who did not have tertiary education were more likely to change their preferences in the repeat interview.

Conclusion
Clinicians may have a better chance of meeting a patient's expectations about the process of care if they assess the patient's desire for knowledge and give those who do not have tertiary education more time to assimilate information about their treatment.
An electro‐optic monitor of the behavior of Chlamydomonas reinhardtii cilia
Authors: Josef Keith , Saranak Jureepan , Foster Kenneth W. 
Published: April 2005

AbstractThe unicellular green alga Chlamydomonas reinhardtii steers through water with a pair of cilia (eukaryotic flagella). Long‐term observation of the beating of its cilia with controlled stimulation is improving our understanding of how a cell responds to sensory inputs. Here we describe how to record ciliary motion continuously for long periods. We also report experiments on the network of intracellular signaling that connects the environment inputs with response outputs. Local spatial changes in ciliary response on the time scale of the underlying biochemical dynamics are observed. Near‐infrared light monitors the cells held by a micropipette. This condition is tolerated well for hours, not interfering with ciliary beating or sensory transduction. A computer integrates the light stimulation of the eye of Chlamydomonas with the ciliary motion making possible long‐term correlations. Measures of ciliary responses include the beating frequency, stroke velocity, and stroke duration of each cilium, and the relative phase of the cis and trans cilia. The stationarity and dependence of the system on light intensity was investigated. About 150,000,000 total beat cycles and up to 8 h on one cell have been recorded. Each beat cycle is resolved so that each asynchronous beat is detected. Responses extend only a few hundred milliseconds, but there is a persistence of momentary changes that last much longer. Interestingly, we see a response that is linear with absolute light intensity as well as different kinds of response that are clearly nonlinear, implying two signaling pathways from the cell body to the cilia. Cell Motil. Cytoskeleton 61:83–96, 2005. © 2005 Wiley‐Liss, Inc.
Refractive index, band gap and oscillator parameters of amorphous GaSe thin films
Authors: Qasrawi A. F. 
Published: April 2005

AbstractGaSe thin films are obtained by evaporating GaSe crystals onto ultrasonically cleaned glass substrates kept at room temperature under a pressure of ∼10–5 Torr. The X‐ray analysis revealed that these films are of amorphous nature. The reflectance and transmittance of the films are measured in the incident photon energy range of 1.1–3.0 eV. The absorption coefficient spectral analysis revealed the existence of long and wide band tails of the localized states in the low absorption region. The band tails width is calculated to be 0.42 eV. The analysis of the absorption coefficient in the high absorption region revealed an indirect forbidden band gap of 1.93 eV. The transmittance analysis in the incidence photon wavelength range of 500–1100 nm allowed the determination of refractive index as function of wave length. The refractive index–wavelength variation leads to the determination of dispersion and oscillator energies as 31.23 and 3.90 eV, respectively. The static refractive index and static dielectric constant were also calculated as a result of the later data and found to be 9.0 and 3.0, respectively. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of tunneling rays to baseband frequency response of step‐index plastic optical fibers
Authors: Yoshimura Tomonari , Koyamada Yahei 
Published: April 2005

AbstractThe transmission bandwidth of a stepped‐index plastic optical fiber (POF) is found to vary significantly with the location of incidence of the light at the POF edge plane. In order to determine the cause, the effect of a tunneling leaky ray on the baseband frequency characteristics of the POF is studied both numerically and experimentally. It is found that the transmission bandwidth becomes narrower due to excitation of tunneling leaky rays if the light is incident from a light source with a wide radiating angle, such as that in a light‐emitting diode (LED), on a position far from the center on the POF edge plane. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 88(8): 12–17, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20166
Radiation and ohmic resistances in very small meander line antennas of less than 0.1 wavelength
Authors: Takiguchi Masato , Yamada Yoshihide 
Published: April 2005

AbstractDemands for extremely small antennas to be used in radiofrequency identification tags for ubiquitous communication have increased. Examples of very small antennas utilizing meander line structures are seen. To date, important studies have been carried out on basic design and on improvement of the radiation efficiency by a folded configuration. Most of the structures studied have dimensions of more than 0.1 wavelength. For the demands of ultracompact antennas, this paper deals with meander line antennas whose dimensions are less than 0.1 wavelength. First, the parameters for resonant configurations are derived for antennas with dimensions of 0.1 to 0.025 wavelength. Next, the radiation resistance and the ohmic resistance are studied in the folded structures. First, through a transmission line model analysis, it is shown that the step‐up ratios of radiation and ohmic resistances in the case of folded structures are different. In addition, these resistances that are basic values of electrical performances are derived through electromagnetic simulations. Further, in order to confirm the validity of the numerical results and the realizable performance, antennas with dimensions of 0.1 and 0.05 wavelength were fabricated. Electrical characteristics are compared, and good agreements are found. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 88(8): 1–11, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20204
Chemical composition of the essential oils of Marrubium parviﬂorum Fisch. & C. A. Mey. and Marrubium vulgare L. from Iran
Authors: Khanavi Mahnaz , Ghasemian Leila , Motlagh Elham Hosseiny , Hadjiakhoondi Abbas , Shaﬁee Abbas 
Published: April 2005

AbstractThe composition of essential oil samples obtained by hydrodistillation of the aerial parts of Marrubium parviﬂorum Fisch. & C. A. Mey. and Marrubium vulgare L. (family Lamiaceae), were investigated by GC and GC–MS. Fifty‐one components in the oil of M. parviﬂorum, representing 96.8% of the total oil, and 34 components in the oil of M. vulgare, representing 95.1% of the total oil, were identiﬁed. Both essential oils were characterized by a high amount of sesqiterpenes (77.8% and 82.5%, respectively) with bicyclogermacrene (26.3%), germacrene D (21.5%) and β‐caryophyllene (15.6%) as the major constituents of M. parviﬂorum, and β‐bisabolene (25.4%), β‐caryophyllene (11.6%), germacrene D (9.7%) and E‐β‐farnesene (8.3%) as the major component of M. vulgare. Copyright © 2004 John Wiley & Sons, Ltd.
Current awareness in flavour and fragrance
Authors:   John Wiley & Sons, Ltd.
Published: April 2005

AbstractIn order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of flavour and fragrance. Each bibliography is divided into 7 sections: 1 Flavour of food; 2 Fragrances; 3 Essential oils; 4 Food constituents; 5 Taints & off‐flavours; 6 Sensory evaluation & psychophysics; 7 Apparatus & methodology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted (10 weeks journals. Search ended 15th. Dec. 2004)