bluuebunny/crossref_metadata_2025_split huggingface dataset:
A large growing occipital meningocele with Dandy–Walker syndrome: A case report and review of the literature
Authors: Matsumoto Shirabe , Iwata Shinji , Harada Atsuko , Imon Hikaru , Seno Toshimoto , Watanabe Hideaki , Kunieda Takeharu 
Published: October 2023

Background:
Dandy–Walker syndrome (DWS) is a well-known developmental anomaly. An occipital meningocele (OMC) is recognized as a malformation that is relatively often associated with DWS, but the association of DWS with OMC has been reported in approximately 40 cases. We present herein a rare clinical course of DWS with OMC, in which the sac was small at birth and became progressively larger.

Case Description:
A 5-day-old baby boy was referred to our hospital due to OMC. He was born at 33 gestational weeks due to premature rupture of the membranes. He was diagnosed as having DWS associated with OMC. The OMC was covered with skin and its maximum diameter at birth was 3 cm. Magnetic resonance imaging showed an occipital bone defect and continuity of the fourth ventricle, posterior fossa cyst, and OMC sac. The aqueduct was patent, and no hydrocephalus was found. The OMC sac increased progressively with moderate hydrocephalus and reached 7 cm at the age of 54 days when his weight was 2508 g. A cystoperitoneal shunt and repair were performed after sinus venography by contrast computed tomography (CT). At the age of 1 year and 8 months, he had moderate developmental disabilities.

Conclusion:
In most cases reported, the OMC was relatively small, and large and giant sizes were reported in only six cases. Almost all cases remained the same size as at birth and underwent surgical intervention as early as possible. It was possible to understand the relationship between the occipital bone defect and abnormal running of sinuses such as the superior sagittal sinus, torcular Herophili, and transverse sinus preoperatively from the CT venography (CTV) image. CTV may be an effective and important method for safely performing repair and shunt.
Surgical management of craniocervical junction tuberculosis with atlanto-axial dislocation – A case report and review of the literature
Authors: Amin Md Rezaul , Rahman Md Tauhidur , Hossain A. B. M. Manwar , Quader Tahsina , Islam KM Tarikul 
Published: October 2023

Background:
There are few guidelines on how to best manage craniovertebral junction (CVJ) tuberculosis (TB). Certainly, timely tissue diagnosis, immobilization of the neck, and decompression of CVJ with appropriate stabilization are the mainstays of treatment for TB at the CVJ.

Case Description:
Three patients, ages 16–68, presented with CVJ TB with atlanto-axial dislocation responsible for progressive quadriparesis/plegia. Based on X-rays, magnetic resonance, and computed tomography studies, patients underwent timely decompressions and fusions followed by antitubercular drug treatment.

Conclusion:
Early diagnosis, proper decompression with fusion, treated with anti-TB drug for proper period were keys to managing TB involving the craniocervical junction in these three patients.
Retrospective study of spontaneous subarachnoid haemorrhage: vasospasm and other complications (Part III)
Authors: Bakanauskaitė S. , Grigaitė J. , Danilevičienė R. , Lizaitienė G. , Piliponis L. , Ščerbak J. , Jatužis D. , Valaikienė J. 
Published: October 2023

Background. Acute subarachnoid haemorrhage (SAH) is a dangerous condition: roughly 50% of patients die within 30 days, nearly 25% develop significant neuropsychological and cognitive deficits, about 10% suffer from other complications, and only around 15% recover fully. One of the main causes of mortality is cerebral vasospasm (CVS), a cause of delayed cerebral ischaemia (DCI), which can lead to secondary cerebral infarction. Thus, early detection of CVS is crucial for improving patient outcomes.The aim of this study was to analyse the demographic and clinical (including complications) data of patients diagnosed with SAH, to evaluate the diagnostic methods, and to investigate the prevalence and treatment of complications.Materials and methods. This retrospective study included 102 patients diagnosed with spontaneous SAH, aged at least 18 years, who were treated in the Vilnius University Hospital Santaros Klinikos (VUL SK) in 2014-2017. The obtained VUL SK data were selected by the I60 ICD-10-CM code and depersonalized. Head computerized tomography (CT), CT angiography (CTA), digital subtraction angiography (DSA), transcranial color-coded duplex sonography (TCCS), and magnetic resonance angiography (MRA) were used to evaluate the cerebral arteries.Results. In 102 patients (mean age 58±16 years; 55% female), the most common cause of spontaneous SAH was ruptured aneurysm, the most common arterial sites were the middle cerebral artery (36%), anterior cerebral artery and/or communicating artery (together 33%), and internal carotid artery (20%). In-hospital mortality was as high as 21%. All patients underwent head CT, 78% CTA, 33% DSA, 8% TCCS, and 1% MRA. 71% patients experienced SAH complications: 66% acute, 27% chronic. The most common acute complications were cerebral oedema (34%), rebleeding (29%), and acute ischaemia (23%), the most common chronic complications hydrocephalus (11%), DCI (9%), and CVS (8%).Conclusions. CVS was diagnosed considerably less frequently in this study compared to other studies. While the diagnosis rates of ischaemia and hyponatremia were likewise significantly lower in this study compared to those in others, they are in line with the CVS diagnosis rate. Aside from the CVS and CVS-related complications, all the other SAH complications were roughly within the range of the other studies.
Etiopathogenic theories of nervous system diseases in Vilnius in the early 19th century: “insanity and epilepsy exacerbate when the moonlight shines”
Authors: Sakalauskaitė-Juodeikienė E. 
Published: October 2023

Neurology as a separate branch of clinical medicine was not yet formed in Europe in the early 19th century. However, in the medical writings of the Vilnius University (VU) authors of that time, the brain was already called the “noblest organ of the human body”, the seat of the soul, the centre of external senses, and the primary beginning of all bodily movements. The aim of the present study is to reveal various etiopathogenic theories of diseases of the nervous system (NS) in Vilnius region, since this knowledge may indicate that there were some beginnings of clinical neurology in the early 19th century in Vilnius. First, we analysed old doctoral dissertations on NS diseases defended at VU in 1803-1832; we then turned to Consessus Caesareae Societatis Medicae Vilnensis (The Protocols of Vilnius Medical Society) and analysed clinical reports recorded in 1806-1842. Our study revealed that although humoralism was the most popular system of medicine, the main causes of NS diseases were believed to be in the solid parts of the human body (influence of solidism theory). It was also assumed that some NS diseases may be inherited or caused by fetal diseases in utero. On the other hand, one of the oldest theories, imaginatio gravidarum, was still prevalent in Vilnius at the time. It was also stated that some NS diseases may be triggered by physical and mechanical causes, concomitant diseases, medications and drinks, strong emotions, or violation of sleep hygiene. “Inflammatory agents” were reported to cause traumatic tetanus as inflammation spread upwards from the nerve endings, tendons, and ligaments to the brain. The authors also described the theory of “poison, specifically acting on the NS” that was transmitted by a rabid animal to a bitten patient. To describe the etiopathogenesis of spinal cord diseases, the concept of “diminishing vital spirits through the loss of bodily matter” was used (it was claimed, e.g., that excessive number of sexual intercourses dried out the spinal cord). In addition, the astrological causes of NS diseases were also believed to be of great importance (“somnambulism, insanity, and epilepsy exacerbate when the moonlight shines”). Finally, cutting off the Polish plait (plica polonica) was considered to be an essential etiological factor of various NS diseases in Vilnius in the early 19th century.
Clinical and psychological correlations with type D personality in patients with chronic coronary syndrome
Authors: Sumin A. N. , Shcheglova A. V. , Anichkova M. I. , Fedorova D. N. , Shabalina K. A. 
Published: October 2023

Recently, it has become common to identify type D personality, which is predisposed to the development of psychological distress. Negative behavioral characteristics of individuals with type D personality contribute not only to the development of cardiovascular diseases, but also to other comorbid pathologies that can influence the progression and prognosis of coronary heart disease. The aim of the study. To identify clinical and psychological correlations with type D personality in patients with chronic coronary syndrome. Methods. The study included 113 patients (68 men and 45 women; median age – 64 years) admitted for planned percutaneous coronary intervention at the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russian Federation). Based on the results of the DS-14 test, patients were divided into two groups: patients with type D personality (n = 40) and patients without this type (n = 73). Results. In patients with chronic coronary syndrome with type D personality, compared with patients without this type, concomitant diabetes mellitus (35 % and 15 %, respectively; p = 0.018), signs of diastolic dysfunction of left (Е/е’ ratio 7.1 [6.48; 8.0] and 5.0 [4.55; 5.74], respectively; p = 0.0038) and right (Et/At ratio – 0.8 [0.66; 1.35] and 1.38 [1.28; 1.63], respectively; p = 0.014) ventricles were more often diagnosed. Correlation analysis revealed associations of diabetes mellitus with type D personality (r = 0.243; p = 0.011), severity of negative excitability (r = 0.253; p = 0.008) and social suppression (r = 0.224; p = 0.020), as well as association of ankle-brachial index (ABI) with the severity of negative excitability (r = 0.393; p = 0.004) and social suppression (r = 0.414; p = 0.002). Conclusion. In patients having chronic coronary syndrome with type D personality, concomitant diabetes mellitus, as well as left and right ventricular filling disorders are more often detected. Correlation analysis revealed associations of diabetes mellitus with type D personality and its subscales; the ABI level was associated with subscales of type D personality, but not with the level of anxiety and depression.
Isolation and whole genome sequencing of a lipophilic anaerobic bacterium, a representative of the species complex <i>Corynebacterium tuberculostearicum</i>, from a tuberculosis focus
Authors: Ogarkov O. B. , Suzdalnitsky A. E. , Kondratov I. G. , Bukin Yu. S. , Orlova E. A. , Sinkov V. V. , Zhdanova S. N. , Belkova N. L. , Rychkova L. V. , Kolesnikova L. I. 
Published: October 2023

Background. The study of the lower respiratory tract microbiome has been actively developed inrecent years with the help of whole genome sequencing (WGS) methods. Due to this, it became clear that the nature of the lungs microbiota is very different from other microbial communities inhabiting the human body. One of the important directions in the study of pathological lungs biocenosis is the study of the role of the satellite microbiota of the tuberculosis focus. The aim of the work. To isolate and characterize oxygen-tolerant anaerobes from the necrotic contents of tuberculomas. Materials and methods. Biopsy material from 5 patients with pulmonary tuberculosis was obtained during a planned surgical treatment of tuberculoma. A pure culture was isolated from one sample during anaerobic cultivation. Lipase activity of strain was determined by plating on brain heart infusion agar (HIMEDIA, India) supplemented with 0.1 % Tween-80 and 10 mM of CaCl2. Antibiotic susceptibility was determined by RAPMYCO and SLOWMYCO of TREK Diagnostic Systems (Thermo Fisher Scientific, USA). DNA from the sediment of the broth culture was isolated by the CTAB chloroform method. Whole genome sequencing was performed on a DNBSeq-G400 NGS sequencer by Genomed (Russia). Results. Based on WGS results and phylogenetic analysis, the strain was identified as Corynebacterium kefirresidentii. The strain was characterized by high lipase activity and resistance only to Isoniazid, Ethionamide and Trimethoprim/Sulfamethoxazolin. Conclusion. The isolation of a lipophilic anaerobic representative of the Corynebacterium tuberculostearicum species complex from a tuberculous focus indicates a possible role of the non-tuberculous microbiota in the liquefaction of caseous necrosis. We assumed that in some cases, favorable conditions are created inside the tuberculous focus for the development of satellite anaerobic lipophilic microbiota.
Effect of a sorbent composition based on aluminum oxide and polydimethylsiloxane on the reproductive system of <i>db/db</i> female mice with genetically determined obesity and type 2 diabetes mellitus
Authors: Dergacheva T. I. , Michurina S. V. , Ishchenko I. Yu. , Starkova E. V. 
Published: October 2023

Metabolic syndrome, obesity, type 2 diabetes mellitus are characterized by the accumulation of toxic metabolic products in the internal environment of the organism. The development of innovative medicines based on a sorbent matrix modified with biologically active molecules remains relevant. The sorbent composition from aluminum oxide and polydimethylsiloxane is considered promising. The aim of the study. To investigate the effect of the sorbent composition from aluminum oxide and polydimethylsiloxane on the uterus and ovaries of db/db mice with obesity and type 2 diabetes mellitus. Materials and methods. The sorbent composition (0.665 g/kg in 200 μl of distilled water) was administered to 14-week-old animals through an intragastric tube once a day for 7 days. The comparison groups were female rats injected with placebo (daily intragastrical administration of 200 µl of water for 7 days) and intact animals. Digital images of light-optical preparations stained with hematoxylin and eosin were processed using Image-Pro Plus 4.1 software. In the ovaries, the numerical density of primordial, primary, secondary follicles and corpus luteum was determined. The width of the uterus layers, the diameters of the blood and lymphatic vessels, the width of the interstitial fissures in both organs were measured. The statistical significance of differences was determined using the Mann – Whitney test. Results. In the myometrium and endometrium of the uterus of db/db mice, dilatation of arteries, veins, lymphatic vessels and edema were noted due to the accumulation of tissue fluid in the interstitium layers. There were no tertiary follicles in the ovaries. The introduction of the sorbent composition contributed to a decrease in the diameters of arteries, veins, lymphatic vessels of the uterus, a decrease in edema in both organs due to the narrowing of the prelymphatic slits, and stimulated an increase in the numerical density of secondary follicles. Conclusion. A corrective effect of the sorbent composition of aluminum oxide and polydimethylsiloxane on prelymphatic slits, blood and lymphatic vessels in the uterus and ovaries in db/db mice with obesity and type 2 diabetes mellitus was revealed.
Prevalence of polycystic ovary syndrome in a population of women of reproductive age using Rotterdam 2003 criteria (literature review)
Authors: Lazareva L. M. 
Published: October 2023

Polycystic ovary syndrome (PCOS) is considered a common endocrine disorder among women of reproductive age, and the associated health risks persist throughout life. At the same time, there is a wide range of variations in the incidence of the syndrome (4–21 %), which in turn is explained by the influence of the study population characteristics, including ethnicity and race, as well as the applied diagnostic criteria. The aim of the study. To systematize the available data on the prevalence of polycystic ovary syndrome using the Rotterdam 2003 criteria in a population of women of reproductive age. Materials and methods. The search for information was carried out using Internet resources (PubMed, EMBASE, Google Scholar, eLibrary). Literature sources for the period 1990–2023 were analyzed. As a result, the article presents current data on the prevalence of PCOS using the Rotterdam 2003 definitions, the features of the PCOS incidence in hospital and non-selective (medically unbiased) populations, as well as in various ethnic groups. The review also discusses current guidelines for conducting studies on the PCOS prevalence. Conclusion. The latest guidelines on the diagnosis and management of patients with PCOS, published in 2018, propose to consider the provisions adopted in Rotterdam as the basis for the diagnosis of the syndrome; at the same time, the need to take into account racial and age characteristics is noted.
SISTEM INFORMASI PENJUALAN JAYA T-SHIRT BLORA BERBASIS WEB
Authors: Suminten Suminten 
Published: October 2023

Teknologi komputer banyak digunakan oleh manusia dan berkembang dengan pesat, baik dalam menyelesaikan permasalahan yang dihadapi maupun pekerjaannya. Komputer juga dapat menjadi alat komunikasi apabila menggunakan fasilitas internet. Bahkan komputer juga berfungsi untuk mengembangkan bisnis untuk perusahaan besar, menengah maupun kecil. Jaya T-shirt merupakan salah satu pelaku bisnis yang masih menggunakan sistem pelayanan kasir yang cukup sederhana. Dengan hanya dicatat pada sebuah buku besar, pelayanan kepada pelanggan menjadi kurang maksimal. Penghitungan hasil transaksi yang hanya mengandalkan sebuah kalkulator dan tanpa dukungan sebuah komputer maupun laptop karena keterbatasan karyawan yang dapat mengoperasikan komputer. Untuk menyelesaikan masalah tersebut maka perlu dilakukan promosi dan pemesanan pembelian secara online menggunakan sebuah aplikasi berbasis web supaya memudahkan pelanggan dalam melakukan pemesanan dan memudahkan karyawan dalam mengelola kegiatan penjualan sampai pembuatan laporan penjualan. Metode yang digunakan untuk membangun aplikasi penjualan yaitu metode pengumpulan data dan metode pengembangan perangkat lunak waterfall. Hasil dari penelitian ini adalah membantu perusahaan dan konsumen dalam layanan transaksi penjualan online tanpa harus dating langsung ketoko untuk melakukan pembelian barang dan membantu perusahaan dalam memperluas wilayah pemasaran tidak hanya diwilayah Blora saja namun skala nasional bahkan global.
RANCANG BANGUN SISTEM PENJUALAN BERBASIS E-COMMERCE PADA TOKO BAHAHARI ELEKTRONIK
Authors: Susandi Diki 
Published: October 2023

Abstrak - Perkembangan teknologi informasi saat ini sangat berpengaruh dalam berbagai aspek kehidupan. Kemudahan memperoleh dan menyebarkan informasi menjadi faktor penting dalam keberhasilan sebuah proses bisnis. Dengan memanfaatkan e-commerce, para penjual dapat menawarkan produknya secara online sehingga memberikan kemudahan berbelanja, bertransaksi, dan pengiriman secara efektif dan efisien. Penelitian ini dilakukan dengan tujuan membangun sistem informasi berbasis e-commerce yang dapat membantu dalam memperoleh keuntungan penjualan dan membantu konsumen dalam melakukan transaksi pembelian pada toko. Sistem dibangun dengan menggunakan metode pengembangan waterfall. Rancangan sistem menggunakan model unified modelling language. Pengujian sistem dilakukan dengan menggunakan metode black box testing. Hasil penelitian berupa sistem informasi penjualan berbasis e-commerce pada toko bahahari elektronik yang dapat membantu dalam proses penjualan produk.

Kata Kunci: E-commerce, Penjualan, Unified Modelling Language, Waterfall.
The level of endothelin-1 in prognostiсation of adverse cardiac remodeling after ST-elevation myocardial infarction
Authors: Vyshnevska I. R. , Petyunina O. V. , Kopytsya M. P. 
Published: October 2023

Most patients have a good survival after myocardial infarction due to modern methods of treatment. However, certain disadvantages are still present today: the incidence of heart failure is increasing dramatically. Supervision those patients needs grate expenses, especially during the war. That is why it is continuing the search of the predictors important in the prognostication of heart failure.
Objective — to determine the value of endothelin‑1 (ET‑1) on prediction of adverse cardiac remodeling in ST‑elevation myocardial infarction (STEMI) patients successfully treated with primary percutaneous coronary intervention.
Materials and methods. We prospectively enrolled 162 individuals with STEMI who were successfully treated with primary percutaneous coronary intervention. The biomarkers (ET‑1, cardiac troponins) and echocardiographic parameters were evaluated at the baseline.
Results. The study group was divided into two: with high and low ET‑1 level, based on median 2.75 pg/ml, which was the cutoff point with the highest combination of sensitivity and specificity calculated using receiver operating characteristic (ROC). ROC analysis demonstrated endothelin prognostic potential for left ventricle remodeling. The cut‑off was less than 2.97 pg/ml (sensitivity — 83%, specificity — 62%, area under curve (AUC) — 0.70, 95% confident interval 0.516—0.847, p=0.03). Endothelin biomarker was evaluated as a possible predictor of left ventricular remodeling using logistic regression analysis. Endothelin‑1 showed properties of predicting adverse cardiac remodeling (95% confident interval 0.696—0.956, AUC — 0.861, χ2=9.03, p=0.43).
Conclusions. Determination of ET‑1 level will allow to use adequate medical management in adverse cardiac remodeling prognosis in STEMI patients to prevent heart failure development.