bluuebunny/crossref_metadata_2025_split huggingface dataset:
Au-delà de l’agroécologie : le ré-ensauvagement agricole, une perspective pour les systèmes d’élevage ?
Authors: CORSON Michael S. , MONDIÈRE Aymeric , MOREL Loïs , VAN DER WERF Hayo M.G. 
Published: October 2023

La conservation et la restauration de la biodiversité impliquent généralement des interventions humaines. En comparaison, le ré-ensauvagement est une approche radicalement différente qui propose de s’appuyer sur les processus écologiques spontanés pour restaurer les écosystèmes. Le ré-ensauvagement, y compris celui des systèmes agricoles, a été examiné d’un point de vue écologique et social, mais peu d’un point de vue agricole. Dans cette revue de la littérature et d’études de cas, nous i) analysons si et comment le ré-ensauvagement des systèmes d’élevage peut contribuer à conserver et restaurer la biodiversité et offrir de nouvelles perspectives, principalement en Europe, et ii) identifions des questions de recherche sur le ré-ensauvagement des systèmes agricoles. Nous avons recherché la littérature portant à la fois sur le ré-ensauvagement et l’agriculture. Nous avons également identifié des projets de ré-ensauvagement agricole établis depuis au moins cinq ans au Royaume-Uni afin d’analyser leurs approches et leurs caractéristiques. Le ré-ensauvagement agricole est une forme émergente d’utilisation des terres que nous positionnons conceptuellement entre l’agroécologie et le ré-ensauvagement. Il combine la restauration des processus écologiques avec un certain degré de production agricole, le plus souvent d’herbivores. Une sélection de 11 projets de ré-ensauvagement agricole au Royaume-Uni portait sur des surfaces allant de 121 à 4 402 ha. Les principales actions visant à favoriser le ré-ensauvagement étaient le pâturage extensif et la restauration d’habitats. Les principales activités économiques étaient la vente d’animaux, le tourisme et l’éducation. Le ré-ensauvagement agricole peut constituer un modèle multifonctionnel vers lequel les systèmes d’élevage herbivore peuvent évoluer pour mieux répondre aux préoccupations environnementales.
Outcomes of 1-Stage Versus 2-Stage Revisions After Hip Prosthetic Joint Infection
Authors: Patel Devon , Sparks Addison , Blood Dalton , Liu Jiayong 
Published: October 2023

Background:
Prosthetic joint infections (PJIs) are significant complications of total joint arthroplasties. The incidence of this dangerous complication is expected to rise, but there is not a unanimous solution. Two-stage surgical revisions are the traditional gold standard of treatment, but recent literature suggests that 1-stage revisions can be equally effective. A comparison of the outcomes of 2-stage revisions vs. 1-stage revisions has not been thoroughly investigated. This systematic review and meta-analysis were designed to compare the outcomes of 2-stage exchanges vs. 1-stage exchanges in the treatments of hip PJI based on comparison studies.

Methods:
MEDLINE, Embase, and Cochrane were searched for relevant studies that compared the effectiveness and outcomes of 1-stage and 2-stage procedures from January 2000 to May 2023. Keywords relating to hip PJI were used, and comparison studies of 1-stage vs. 2-stage procedures that reported patient characteristics and outcomes including success rates, rates of reinfection, or other outcomes such as functional outcomes (e.g., mean Harris hip scores), infection-free survival, and blood loss were included. Statistical analysis for this study was conducted using Review Manager 5.4 with a standard p-value of ≤ 0.05 for statistical significance.

Results:
Fifteen articles and 1,017 patients were included in the meta-analysis. One-stage revision procedures (320 patients) were found to have greater success rates (i.e., lower rates of reinfection) than 2-stage revisions (697 patients) (p = 0.04). One-stage revisions (184 patients) had shorter durations of operation and less blood loss than 2-stage revisions (90 patients) (p < 0.05).

Conclusion:
One-stage revision procedures are associated with lower reinfection rates, blood loss, and durations of operation compared with 2-stage revisions.

Level of Evidence:
I.
Outcomes of Sling Procedure Using a Free Vascularized Fibular Graft After Resection of the Proximal Humerus
Authors: Tsuchiya Ryuto , Kobayashi Eisuke , Fukushima Suguru , Arikawa Masaki , Ogura Koichi , Iwata Shintaro , Akazawa Satoshi , Kawai Akira 
Published: October 2023

Background:
The proximal humerus is a common site for both primary and metastatic bone tumors. Although various methods have been developed for reconstruction following resection of the proximal humerus, a consensus on which technique is best has not been established. We focused on the sling procedure using a free vascularized fibular graft (FVFG) and conducted what we believe to be the largest retrospective study of patients to undergo this surgery to date.

Methods:
We retrospectively reviewed the data of 19 patients who underwent the sling procedure with use of an FVFG at our hospital between 1998 and 2022. The median age was 20 years, and the median follow-up duration was 63.1 months. Surgical data, oncological outcomes, the postoperative course, complications, and functional outcomes as measured with use of the Musculoskeletal Tumor Society (MSTS) score were thoroughly reviewed.

Results:
The median operative duration was 555 minutes, and the median blood loss was 374 mL. The median length of the bone defect was 17.0 cm, and the median length of the graft was 20.0 cm. With respect to oncological outcomes, 9 patients were continuously disease-free, 9 patients had no evidence of disease, and 1 patient was alive with disease. Bone union was present in 13 of the 17 patients for whom it was evaluable. The median time to bone union was 4 months. Graft growth was observed in 2 pediatric patients. Postoperative fracture was a major complication at the recipient site. The incidence of pseudarthrosis significantly increased when the FVFG could not be inserted into the remaining humeral bone or was split in half (p = 0.002). Although a few patients demonstrated peroneal nerve palsy at the donor site, the symptom was temporary. The overall functional outcome was favorable, with an average MSTS score of 66.9%.

Conclusions:
The sling procedure demonstrated a low complication rate and a favorable functional outcome overall. Therefore, we believe that this procedure is a useful reconstruction method for patients in a broad age range who have a wide defect of the proximal humerus.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
A Real-Time Inversion Approach for Fluid-Flow Fractures in Unconventional Stimulated Reservoirs
Authors: Sheng Guanglong , Zhao Hui , Huang Luoyi , Huang Hao , Liu Jinghua 
Published: October 2023

Summary
Fluid-flow fractures, through which fluids can move under pressure, make a more significant contribution to increasing production than do microseismic and propagation fractures. An accurate description of the distribution of fluid-flow fractures is the basis for evaluating hydraulic fracturing and oil/gas recovery. In this study, a real-time inversion approach for fluid-flow fractures was proposed, and the complex fluid-flow fracture morphology was obtained in real time by updating the data of the fracturing construction curve. First, a dynamic permeability model was proposed to describe the filtration rate of the fracturing fluid during hydraulic fracturing. Combined with the point source function, the flowing bottomhole pressure (pwf) can be quickly calculated based on the fracture morphology and displacement of the fracturing fluid. The variance of pwf and bottomhole pressure (pwb) obtained by pump pressure were used as an objective function, and the length of fluid-flow fractures and fracture morphology were used as fitting parameters. The length of the fluid-flow fractures was updated with the simultaneous perturbation stochastic approximation (SPSA) to achieve a rough fitting of the bottomhole pressure. On this basis, a probability function was used to constrain the randomness of the fractures, and the fracture morphology with a fixed fracture length was continuously simulated and finely matched. Finally, a complex fluid-flow fracture morphology was obtained. The method was used to analyze the fluid-flow fracture morphology of multifractured horizontal wells in shale reservoirs, and the fitting rate of the fracturing construction curve was more than 95%. The results show that the total length of the fluid-flow fractures in one stage in naturally fractured reservoirs was approximately 629 m, and those in homogeneous reservoirs and high-stress difference reservoirs were 564 m and 532 m, respectively. The length of fluid-flow fractures with “grooves” in the fracturing construction curve was longer than the length of fluid-flow fractures with “bulges.” The effectively stimulated reservoir area with fluid-flow fractures was only approximately 28–51% of the stimulated reservoir area with microseismic fractures.
Cost drivers of international grains and oilseeds trade
Authors: Verschuur Jasper , Vittis Yiorgos , Obersteiner Michael , Hall Jim 
Published: October 2023

Abstract

Despite the importance of international trade for food security, high production costs and trade frictions are still prevalent, contributing to regional heterogeneities in the landed cost of food commodities. Here, we quantify the landed cost for six grain commodities across 3,500 subnational regions. We find large heterogeneities in the costs of imported foods, which are highest in Oceania, Central America and landlocked Africa. While some regions have uniform landed costs across sourcing locations, others face large cost spreads across trading partners causing volatility in food prices. Regions with high transport costs are more sensitive to price shocks to food production/transport inputs. We find that most regions could benefit from a targeted approach to reduce landed cost while others benefit from a mixed strategies approach. Our results highlight that spatial information on production, trade and transport is essential to inform policies aiming to build an efficient and resilient global food system.
Management of hyperleukocytosis and results of leukapheresis in childhood acute leukemia: A single center experience and review of the literature
Authors: TERZİ ÖZLEM , Ayçiçek Ali , Uysalol Ezgi Pasli , Hançerli Özgü , Solgun Hüseyin Avni , Göktürk Osman , Ekinci Mehmet Selim , Bayram Cengiz 
Published: October 2023

Abstract
Background
Hyperleukocytosis in pediatric acute leukemia is associated with increased morbidity/mortality and there is no consensus on the use of leukapheresis(LP) for its management.The aim was to review patients' clinical characteristics and outcomes with newly diagnosed leukemia with hyperleukocytosis(HL).
Methods
A retrospective case control study reviewed data from a single institution over a 5-year period.Hyperleukocytosis was present in 41 patients with acute leukemia and were included in the study.Treatment strategies included hyperhydration, administration of allopurinol or rasbirucase, early induction of induction chemotherapy(CT), and LP.
Results
Twenty seven (65.9%) of the 41 patients were male and the median age was 7(range 1–17) years.LP was used in 9 of 41 (13%) patients with hyperleukocytosis and a total of 25 LP procedures were performed.The mean leukocyte value after apheresis was 65,529/mm3.In patients with and without LP, tumor lysis syndrome was seen in 2(23%) and 2(6.25%) patients, respectively.Pulmonary leukostasis was seen in 2 patients, one of whom underwent LP.The mean leukocyte count in patients who received LP versus those who did not was 520.000 cells/mm3 and 158.800 cells/mm3, respectively(p = 0.01).The time from presentation to the initiation of CT was the same between those who received LP and those who did not (mean of 17h and 18h) (p > 0.05).During the first 30 days after presentation, cerebral leukostasis/coagulopathy or pulmonary leukostasis-related early death did not occur in patients with leukemia.
Conclusions
The use of LP in patients with hyperleukocytosis is safe and effective.
Double-stranded RNA targeting white mold Sclerotinia sclerotiorum argonaute 2 for disease control via spray-induced gene silencing
Authors: Marzano Shin-Yi Lee , Beligala Gayathri , Mukherjee Soumya , Feng Chenchen 
Published: October 2023

Abstract

Sclerotinia sclerotiorum, the causal agent of white mold infection, is a cosmopolitan fungal pathogen that causes major yield losses in many economically important crops. Spray induced gene silencing has recently been shown to be a promising alternative method for controlling plant diseases. Based on our prior research, we focus on developing spray-induced gene silencing approach to control white mold by silencingS. sclerotiorumargonaute 2 (SsAgo2), a crucial part of the fungal small RNA pathway. We compared the lesion size as a result of targeting each ~500-bp segments of SsAgo2 from 5’ to 3’ and found that targeting the PIWI/ RNaseH domain of SsAgo2 is most effective. External application of double-stranded RNA (dsRNA) suppressed white mold infection using eitherin vitroorin vivotranscripts was determined at the rate of 800 ng/0.2cm2area with a downregulation of SsAgo2 from infected leaf tissue confirmed by RT-qPCR. Furthermore, magnesium/iron-layered double hydroxides (MgFe-LDH) nanosheets loaded within vitroandin vivotranscribed dsRNA segments significantly reduced the rate ofS. sclerotiorumlesion expansion.In vivoproduced dsRNA targeting the PIWI/RNaseH domain of the SsAgo2 transcript showed increased efficacy in reducing the white mold symptoms ofS. sclerotiorumwhen combined with LDH nanosheets. This approach is promising to produce a large scale of dsRNA that can be deployed as an environmentally friendly fungicide to manage white mold infections in the field.
Assessing the Influence of Shifting Thermal Regimes on Tomato fruit borer, Helicoverpa armigera (Hubner) in the Eastern Himalaya: Implications for Pest Management Strategies
Authors: Patra Sandip , Chakraborty Debasish , Verma V. K. , Pande Rachna , Sangma Rumki H. Ch. , Chakraborty Mahasweta , Layek Jayanta , Hazarika S. 
Published: October 2023

Abstract

Climate change especially the change in the temperature is having profound impacts on the pest population of tomato, a crucial commercial crop, in the Eastern Himalayan Region of India. To understand the impact of different thermal regimes on the fruit borer of tomatoes, field experiments were conducted at three locations with altitudes ranging from <500 to >1500 meters. At lower altitudes, fruit borer incidence was found to commence earlier in the season (5th - 18th March) and had a higher peak population (1.47 to 1.73 larvae/plant) causing more fruit damage (26-29%) as compared to the highest location (~9%). Correlation analysis indicated that maximum and minimum temperatures had significant positive impacts on the H. armigera incidence and fruit damage. Climatic datasets indicate an increase in the temperature of the region during the tomato growing season, thereby increasing the risk of fruit borer impact. As an adaptation option, we evaluated eight different tomato varieties/genotypes and studied biochemical parameters to understand their tolerance. Results showed a strong positive association of fruit borer incidence with total soluble solids and lycopene whereas negative association with acidity. Among the varieties/genotypes, Cherry tomato (7.62%) and MT-2 (10.04%) had relatively lower fruit damage; MT-3 (50.92 t/ha) and MT-2 (50.57 t/ha) consistently yielded the highest across all locations. Hence, the selection of appropriate genotypes and the development of varieties with suitable characteristics hold the key to fruit borer management. These findings can be valuable for pest management, understanding its further spread, and agricultural planning in the region.
ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment
Authors: Yu Ming 
Published: October 2023

Abstract
Successful embryo implantation necessitates a synergistic interaction between the receptive uterine endometrium and the competent embryo. During the "window of implantation" stage, the endometrial epithelium is coated with a layer of glycocalyx, where terminal sialic acid and fucose on glycans play a crucial role in facilitating embryo attachment. In this article, we study the role of ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) and its regulated Sialyl Thomsen-nouvelle (sTn) glycan structure in controlling endometrial function. IHC results showed that ST6GALNAC1 and sTn are mainly located in the endometrial epithelium, and their expression is elevated in receptive endometrium relative to non-receptive endometrium. In vitro embryo implantation model verified that manipulating the endometrial sTn by over- or down-regulation of ST6GALNAC1 influenced the receptiveness of AN3CA and Ishikawa cells to JAR-spheroids. Immunoprecipitation combined with mass spectrometry identified certain adhesion molecules (CD44 and integrin β1) are highly modified with sTn by ST6GALNAC1 in endometrial cells. We next focus on sialic acid-binding immunoglobulin-like lectin 6 (Siglec-6) since it recognizes sTn and analysis results of published single-cell sequencing dataset showed that SIGLEC6 was mainly concentrated in the polar trophectoderm of the human embryo. Ectopic expression of Siglec-6 promotes the adhesiveness of HTR8/Svneo-spheroids on endometrial cells, and more importantly, we confirmed that Siglec-6 binds with sTn-modified CD44. This study demonstrates that endometrial sTn regulated by ST6GALNAC1 facilitates embryo attachment via binding with trophoblastic Siglec-6, which gives a better understanding of the glycobiology of implantation.
Polyaniline Decorated TiO2 nanocomposite as Efficient Catalyst for Ultrasound Synthesis of Dihydropyrimidinones.
Authors: Handore Kalpana N. , Chabukswar Vasant , Jagtap Smita 
Published: October 2023

Abstract
The paper describes the synthesis of conducting polyaniline - TiO2 nanocomposite by using chemical oxidative polymerization method using aniline as a monomer. TiO2 nanoparticles were synthesized by sol gel method using TiCl4 and ethanol. Synthesized TiO2 nanoparticles and nanocomposite were characterized by various spectroscopic techniques UV, FT-IR, XRD, SEM and TGA. The XRD pattern confirms the appearance of sharp diffraction patterns indicates the small size with high purity TiO2 nano particles are highly agglomerated with spherical morphology. The polyaniline-TiO2 nanocomposite was employed as a promising heterocyclic, reusable catalyst for most of the organic synthesis. Nanocomposite of polyaniline -TiO2 is an efficient, solvent free, ultrasound assisted synthesis of biologically active dihydropyrimidin-2(1H)-one/thiones (DHPM) derivatives. The advantages of this methodology are mild reaction conditions with short reaction time, excellent yields, low loading and reusability of catalyst.
Catching Astrocyte Ensembles: Astrocytic Ensembles Control
Cue-motivated Behavior
Authors: Navarrete Marta , Serra Irene , Quintanilla Juan , García-Marqués Jorge 
Published: October 2023

Abstract

Astrocytes, dynamic cells that play a crucial role in brain function, have traditionally been overshadowed by the emphasis on neuronal activity in regulating behavior. This is in part due to the lack of tools to experimentally map and manipulate specific subsets of astrocytes based on their functional activity, which hampers our understanding of how astrocyte networks contribute to the organization of behavior. Here, using a tool that can translate astrocytic activity–mediated calcium signals into gene expression in a light-dependent manner, we have identified an active astrocytic ensemble -which refers to active astrocytes working together- associated with cue-motivated behavior in the Nucleus Accumbens (NAc), a central hub in the reward system. We mapped behavior-related astrocytic ensemble activity to the ventral and posterior regions of the NAc. Furthermore, we demonstrated that direct activation of this specific astrocytic ensemble through optogenetics was sufficient to retrieve the direction of labeled reward behavior. Overall, these findings uncover the fine-tuning role of astrocytic ensembles in shaping salient behavior.
Porphyromonas gingivalis promotes the transendothelial migration of monocytes through the MIF/p38/JAM-A axis in monocytes
Authors: Park Hae Ryoun , Rho Jee Hyun , Woo Bok Hee , Hyeon Jin Yi , Kim Hye Jung 
Published: October 2023

Abstract
Although several previous studies have reported that periodontitis is associated with the progression of atherosclerosis, the underlying mechanisms remain unclear. Periodontal bacteria can cause atherosclerosis by promoting the attachment of monocytes to endothelial cells through the circulatory system. However, it has not been elucidated whether periodontal pathogens stimulate transendothelial migration (TEM) of monocytes and the mechanisms. In the present study, we investigated the effect of periodontal bacteria on the development of atherosclerosis by observing the contribution of periodontal pathogens on TEM. Porphyromonas gingivalis (P. gingivalis) promoted both the adhesion and TEM of THP-1 cells, whereas Fusobacterium nucleatum (F. nucleatum) only promoted adhesion. Interestingly, infection of monocytes with F. nucleatum induced aggregation, which may inhibit TEM of monocytes. Pathogen infection in THP-1 cells had significantly increased expression of pro-inflammatory cytokines. Pathogen infection increased the expression of adhesion-related molecules in both THP-1 and EA.hy926 cells. However, the expression of junctional adhesion molecule-A (JAM-A) increased in THP-1 cells but decreased in EA.hy926 cells following infection. Promotion of JAM-A expression by periodontal pathogens in THP-1 cells was found to be regulated by the macrophage migration inhibitory factor (MIF) signaling pathway. P38 signaling activated by P. gingivalis stimulation was reduced by neutralizing the MIF receptor CD74 antibody, but JNK and ERK1/2 pathways were not involved. Increased adhesion of monocytes to endothelial cells was also observed in mice intravenously injected with P. gingivalis. This study provides new insights into the mechanisms by which P. gingivalis promotes monocyte adhesion and TEM via the MIF–p38–JAM-A axis.
Pharmacologic Treatment and Length of Hospitalization for Neonatal Abstinence Syndrome (NAS) in an Open Bay Neonatal Intensive Care Unit (NICU) Using Novel Non-Pharmacologic Interventions
Authors: Robinson Tonya , Stikes CLC RNC-NIC MSN Reetta , Sorrell C-ONQS C-EFM CLC RNC-OB BSN Jaki , Gater RNC-NIC RN MSN Amanda , Gardner RNC-NIC MSN Amanda , Greenwell RN BSN Colleen , Booth Ph Adam , Businger BCPS PharmD Shannon , Low PharmD Ryan , Petrie CIMC DPAM MSCS OTR/L MS Rachael 
Published: October 2023

Abstract
Objective
Evaluate effectiveness of a novel horizontal rocking bassinet for the management of neonatal abstinence syndrome (NAS).
Study Design:
Prospective cohort study of infants ≥ 35 weeks admitted to an open bay neonatal intensive care unit (NICU) for NAS. Three patient subsets analyzed: controls/Group 1, structured non-pharmacologic interventions (NPI)/Group 2, and structured NPI including the novel bassinet/Group 3.
Results
Group 3 had significant increases in length of stay (LOS) compared to Group 1 (p = 0.006) and Group 2 (p = 0.013). Group 3 had significantly higher length of treatment (LOT) than Group 1 (p = .041). Group 3 had significantly higher total mg/kg morphine exposure than Group 1 (p = .006).
Conclusion
The novel bassinet was not effective as a NPI based on LOS, LOT, and total mg/kg morphine exposure for NAS patients in this study. Further research is needed before novel bassinets are adopted for routine NAS care.