bluuebunny/crossref_metadata_2025_split huggingface dataset:
School health service in the Southern District of Israel - between privatization and nationalization
Authors: Dadon Tzion , Bayer Ya'akov M , Rosenthal Anat , Gdalevich Michael 
Published: January 2024

Abstract

Background
For over three decades, Israel’s economic policy has favored privatization of public services, including healthcare, generating an ongoing and prolonged debate. In 1997 school health services (SHS) for elementary and middle school pupils had undergone privatization that led to reduced budgets, as well as standards, for nurses and physicians. Following these changes, the service has dwindled and is now focused primarily on vaccinations. Between 2007 and 2012, under private management, in the Southern District, service quality diminished substantially, leading to a significant decline in vaccination coverage. Consequently, in 2012, a decision was made to revert the SHS back to state control.
Methods
This study analyzes the differences in the operation of SHS between the period the service was operated by a private contractor (2011-2/2012) and the period operated by the Ministry of Health (3/2012–2013). We examined the vaccination coverage rates, screening tests and health education provided in schools.
Results
We found a statistically significant increase in health services per pupil in the Southern District of the Ministry of Health following the nationalization of the service. There was a significant increase both in routine vaccinations’ coverage and screening tests, but a slight reduction in health education activities.
Conclusions
These findings indicate the benefits associated with the management of health services by the state and its institutions, in conjunction with other services at both national and district levels. The case study of SHS in the Southern District of Israel can serve as an important example highlighting the impacts of privatization vs nationalization of health services, with potential implications in other fields. These insights should be integral to future discussions of healthcare service privatization
A thrombosed left ventricular aneurysm simulating an intra -myocardial dissection hematoma: a diagnostic dilemma
Authors: Sun Zhenxing , Cai Yu , Zhang Ziming , Zhang Li , Xie Mingxing 
Published: January 2024

Abstract
A thrombosed LV aneurysm simulating an Intra-myocardial dissection hematoma (IDH) is a rarely reported condition. We describe a rare case of a 52-year-old man suffering from a thrombosed LV aneurysm, who was initially diagnosed as an IDH by conventional echocardiography. Finally, the patient was diagnosed with thrombosed LV aneurysm through multimodal imaging. We discuss the diagnostic process and surgery of the thrombosed LV aneurysm.
Extrachromosomal DNA Couples with ATM-mediated DNA Damage Response for Genome Instability in Tumors
Authors: Gan Haiyun , Kang Xing , Li Xinran , Zhou Jiaqi , Zhang Yang , Hu Suili , Deng Zhiwen , Wu Yuchun , Wang Nan , Xu Yajing , Chen Liangming , Chen Jinyi , Yue Zhen , Yao Yuan , Yang Xinran , Yao Sitong , Tian Congcong , Wen Qing , Liang Xiaoyan , Yan Lixia , Depies Olivia M , Chan Kui ming , Liang Xiaohuan , Dai Junbiao , Wang Zhiquan , Yu Chuanhe , Li Gang , Liu Xiangyu 
Published: January 2024

Abstract

Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells by conferring survival advantages over normal cells. However, the functional importance of ecDNA replication and maintenance is yet to be evaluated, and the molecular components that contributed to these processes remain largely unknown. Here, using CRISPR-C (circularization of genes and chromosomes by CRISPR) technology and synthetic circular DNA mimicking ecDNA identified in tumors, we generated ecDNA-positive (ecDNA+) cell models. Using these models, we identified the proteins involved in ecDNA replication and maintenance and found DNA damage response (DDR)-related pathways were significantly enriched. We further demonstrated that ecDNA replication led to increased DDR and genome instability and DDR was also essential for ecDNA maintenance, consistent with observations that ecDNA+ tumors exhibited higher DDR scores than ecDNA-negative (ecDNA–) tumors in patients. ATM, MDC1, and CHK2, but not ATR, were activated in ecDNA+ cells compared to ecDNA– cells. Moreover, ecDNA+ cells were more sensitive to ATM and CHK2 inhibition. We further found that type II topoisomerase TOP2B and DNA ligase III (LIG3) were critical regulators for ecDNA replication and maintenance and related DDR. In summary, our findings of the reciprocal interactions between ecDNA and DDR provide new insights into detection and therapy for ecDNA+ tumors.
Carbon Pricing Drives Critical Transition to Green Growth
Authors: Mengesha Isaak , Akkerman Joos , Roy Debraj 
Published: January 2024

Abstract

Carbon pricing is a crucial tool in the efforts to address and mitigate climate change. In 2014, only 12% of carbon emissions fell under carbon pricing at USD7 per tonne; now, about 23% of greenhouse gas emissions are priced at USD32 per tonne. However, the regressive nature of carbon pricing can disproportionately affect low-income populations and potentially reduce political support and public awareness. This raises questions about the dynamics of increasing carbon pricing rates and the optimal balance between inequality, emissions, and economic growth. We find that a critical level of carbon pricing can induce tipping points; incentivizing technological adoption and fuel-switching behavior of energy producers. By combining carbon pricing with redistributive measures at these tipping points, we demonstrate that emissions can be rapidly reduced while maintaining economic growth and decreasing inequality. We also introduce real-time metrics for detecting sector-specific tipping points, without requiring counterfactual analysis. Our research has important implications for the ongoing debate around the relationship between economic growth, inequality, and environmental sustainability.
Parametric study on the decarbonization potential of structural system and concrete mix design choices for mid-rise concrete buildings
Authors: Hafez Hisham , Bajić Petar , Aidarov Stanislav , Malija Xhemsi , Drewniok Michal , Purnell Phil , Tošić Nikola 
Published: January 2024

Abstract

Mid-rise reinforced concrete buildings are projected to continue being the predominant typology for urban development. Thus, reducing the carbon footprint of such buildings is critical for achieving a sustainable built environment. Reducing the amount of concrete and steel in a building through structural and mix design optimization is identified as a primary resource efficiency strategy. This paper is among the first to present evidence of the decarbonization potential of these dematerialization strategies on a building level. The study combines structural design choices such as slab system design, steel reinforcement optimization and span width with materials-based strategies, such as low binder concrete and low-carbon binders. For each scenario, material quantities are calculated following design prescriptions by EN1992-1-1 while state-of-the art life cycle inventory data are adopted to calculate the carbon footprint. Results show that shifting towards more efficient structural systems (i.e., waffle slab system) could save up to 20% of the carbon footprint on the building level compared to more traditional systems, such as slab on beams and flat slabs. In addition, reducing the spans from 7.5 to 5 m can save up to 20% more. Finally, the use of low-clinker cement in low-binder concrete can save another 50% in terms of CO2 impact per built-up area. Realistically, results of the case study concluded that implementing these three strategies could reduce the typical 232 kg CO2e/m2 value of the carbon footprint of structural elements of a mid-rise building up to only 58 kg CO2e/m2, i.e., a four-fold reduction.
Adjuvant hyperthermic intraperitoneal chemotherapy in locally advanced colorectal cancer: A propensity score matched cohort study
Authors: Yang Junbo , Sun Kai , Mou Tingyu , Liu Hao , Chen Xinhua , Deng Haijun 
Published: January 2024

Abstract
Background
The benefit of the application of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) to the prognosis of locally advanced colorectal cancer (CRC) patients is unclear.
Methods
In total, 3008 consecutive CRC patients who underwent resection at Nanfang Hospital from September 2013 to May 2018 were analyzed. After Propensity score matching (PSM), the HIPEC group (n = 188) and control group (n = 188) were compared by surgical outcomes, complications, and long-term survival. Uni- and multivariate analyses were conducted to confirm the role of HIPEC in the prognosis.
Results
After PSM, there were no statistically significant differences in all the baseline parameters between two groups. However, the operation time in the HIPEC group was longer. Regarding recovery courses, the HIPEC group takes more time. There was no significant difference between the two groups regarding intra-abdominal infection, ileus, intestinal fistula, anastomotic leakage, lymphatic leakage, pancreatic fistula, uroschesis, pulmonary infection, urinary infection, and cerebrovascular events. However, wound infection was more severe in the HIPEC group than in the control group. The 3-year overall survival (OS) and disease-free survival (DFS) rates, respectively, were 87.2% and 81.7% in the HIPEC group, and 80.5% and 75.2% in the control group. Multivariate analyses revealed that HIPEC, ASA score > II, laparoscopic approach and advanced tumor T and N stages were independent predictive factors for superior OS and DFS.
Conclusions
Adjuvant HIPEC with more reasonable regimens, cycles, and duration could independently improve the prognosis in patients with locally advanced CRC.
Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment
Authors: Wang Leyu , Li Liangyu , Liu Xiaotong , Liu Guanghe , Xu Suying , Hu Gaofei 
Published: January 2024

Abstract

The optimization of the enzyme-like catalytic selectivity of nanozymes for specific reactive oxygen species (ROS)-related applications is significant, and meanwhile the real-time monitoring of ROS is really crucial for tracking the therapeutic process. Herein, we present a mild oxidation valence-engineering strategy to modulate the valence states of Mo in Pluronic F127-coated MoO3 − x nanozymes (denoted as MF-x, x: oxidation time) in a controlled manner aiming to improve their specificity of H2O2-associated catalytic reactions for specific therapy and monitoring of ROS-related diseases. Experimentally, MF-0 (Mo average valence 4.64) and MF-10 (Mo average valence 5.68) exhibit exclusively optimal catalase (CAT)- or peroxidase (POD)-like activity, respectively. Density functional theory (DFT) calculations verify that the energy barriers from H2O2 to O2 and ·OH for MF-0 are 1.84 eV and 2.24 eV, while for MF-10 showing as 2.13 eV and 1.00 eV, disclosing the mechanism of the H2O2 activation pathway on the Mo-based nanozymes. Furthermore, MF-0 poses a strong potential in acute kidney injury (AKI) treatment, achieving excellent therapeutic outcomes in vitro and in vivo. Notably, the ROS-responsive photoacoustic imaging (PAI) signal of MF-0 during treatment guarantees real-time monitoring of the therapeutic effect and post-cure assessment in vivo, providing a highly desirable non-invasive diagnostic approach for ROS-related diseases.
Pipeline Multi-type High Consequence Area Identification Based on Mask R-CNN with Fused Attention Mechanisms
Authors: dai xiaojun , huang weiyi , xiao jianghong , wei peng , ming xi 
Published: January 2024

Abstract

High-consequence Area identification is a fundamental work and the first link in pipeline integrity management, but the current traditional identification technologies and methods generally have low efficiency, high cost, poor timeliness, low accuracy and other problems. For this reason, this paper proposes an all-type identification method of pipeline high consequence area based on the improved algorithm Mask R-CNN. Firstly, the pixel-level instance segmentation of remote sensing images using annotation tools generates masks for high recognition accuracy, and combines the training and validation datasets according to the type of high-consequence areas to realize the multi-type recognition of high-consequence areas. Secondly, in the algorithm, the algorithm is improved by adding the CA attention mechanism module to reduce the training time and improve the feature representation ability, and the pipeline division is performed by superimposing vector data and pipeline staking numbers on the image to reduce the interference of terrain and vegetation. Finally, the algorithm is used for automatic identification and extraction of various types of elements, and high consequence zones are established along both sides of the pipeline, and the grade and scope of the high consequence zones are determined according to the relevant specifications. Using this method to identify high consequence zones of branch pipelines in Jieyang-Meizhou section of Guangdong Province, the results show that: 1, the improved algorithm in the identification of densely populated, geologic hazards, flammable and explosive high consequence zones of the average accuracy of the identification of 1.7%, 3.4%, 3.9%, respectively, and the average accuracy of the average category of the average value of the increase of 3%. 2, the experiments have identified a total of 1 geologic hazards of high consequence zones, flammable and explosive high Consequence Area 1, Flammable and Explosive High Consequence Area 5, compared with the traditional identification method building elements increased by 8 buildings, pipeline mileage increased by 0.311 kilometers. This method improves the accuracy and timeliness of the identification of high-consequence zones, and the research results can help the pipeline integrity management intelligently.
Extreme wind speed modeling across Garoua city and Implications assessing for the flight activities
Authors: Daïka Augustin , Etoundi Honoré Messanga , Biouele Cesar Mbane 
Published: January 2024

Abstract

Extreme wind speed characteristics in Garoua city are not well understood. Hence, the paper analyses the directions, intensities, spatial and temporal distributions, variability, and trends of extreme wind events using wind speed data that span between the 2012–2017 period and measured at a height of 10 m, using the R and MATLAB programs. The results obtained show that the wind blows a little almost from all directions and the dominant direction is from the North-West with more than 40% of winds in this direction, the dominant axis is SE-NW with more than 55% of winds in this axis and the annual mean wind speed at a height of 10 m is 5 m/s in 2014. It was further shown that it decreased until it was canceled in 2017 characteristic of the calm wind. In addition, based on the hydrodynamic model, the results displayed that the trajectory presents significant curvature of extreme wind speeds with the hydrodynamic characteristics of the wind flow, and the extreme velocities were distributed according to Weibull's law. This fact denote a problem for lighter aircrafts, whose crosswind rates are lower. In this context, the forecast of high wind speed intensities and directions becomes very central.
A Simple Processed Waste Composite Board Product with Superior Properties than The Market Wood Board
Authors: Surtiyeni Neni , Fadhillah Zahra Muthi , Salim Allamah , Khairurrijal Khairurrijal , Rusydi Andrivo 
Published: January 2024

Abstract

Municipal waste as a renewable resource has been processed into biocomposite boards as a substitute for wood to reduce environmental pollution. The biocomposite performance is governed through the interface between the fibers and the polymer matrix. However, the manufacture of biocomposites is often limited to the use of homogeneous types and sizes of fibers, with complex chemical or biological treatment of fibers to improve interfacial compatibility. Herewith, we report success in increasing compatibility through simple mechanical and physical treatment. The increase in the mechanical properties of biocomposites is influenced by variations in filler fiber sizes, the maximum polymer coating on the filler surface, and the addition of reinforcing elements to the biocomposite board structure. Variations in size of plant fiber can be obtained through mechanical treatment with single milling process, while physical treatment of repeated hot-press processes ensure that polymer coats the entire fiber surface. Furthermore, glass fiber laminate is added to the middle of the board as a structural reinforcement. Our result shows that the properties of the simple processed biocomposite have strength equivalent to commercial particle board and Albasia wood, as well as better fire resistance properties than Albasia wood. This makes waste composite boards suitable as a new substitutes for wood boards.
Extensive thigh pyomyositis secondary to cystic fistulae due to anaerobic-bacterial infection in a kidney transplant recipient
Authors: Hamine Salma , Derbel Haytham , Melica Giovanna , Kodjo-Awiti Edem , Matignon Marie , Morel Antoine 
Published: January 2024

Abstract

Background
Management of infectious complications following kidney transplantation (KT) remains a major challenge. Infectious events appear to be the most common non-cardiovascular causes of death in kidney transplant recipients. The urinary tract is the site most frequently affected by infections in this population, resulting in a high level of morbidity and mortality and significant economic costs.
Case presentation
This case report highlights an extensive thigh pyomyositis secondary to cystic fistulae, which is an extremely rare complication of urinary tract infection in a kidney transplant recipient of 84-year-old, who was referred to our hospital for acute onset fever pain in inner thighs and pyuria. CT-scan depicted bilateral thighs pyomyositis with multiple abscessed collections of the soft parts of adductor with hydroaerobic levels. Cystic fistulae complicated with pubic symphysis osteitis were also discovered.
Conclusion
In kidney transplant recipients, lower limb pyomyositis is an extremely rare condition that should be systematically investigated in case of urinary tract infection, given the high prevalence of such affliction in this population.
Vector Projection of a Construction Made with a Rule and Compass to Understand Squaring the Circle
Authors: Diaz José Rodrigo Alejandro Martinez 
Published: January 2024

Abstract
The conditions of the problem establish the definition of a right triangle whose angle subtends the opposite cathetus with a value equal to alpha = arctan (1/ sqrt{pi}). Starting from this main condition, a series of steps are proposed to compare the precision between two idealized methods that describe the construction of a circle and a square linked to the triangle mentioned above. The first approximation is made taking into account "valid" compass and ruler constructions to obtain such geometric figures. The second construction is based on the lengths obtained by intersecting the previously mentioned geometric figures by performing the vector analysis. In both cases, the areas of the circle and square obtained are compared to find out if they are equal.
HN1-mediated Activation of Lipogenesis Through AKT-SREBP Signaling Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis
Authors: Kim Soo Mi , Jin Hua , Meng Ruoyu , Li Cong Shan , kim Seong Hun , CHAI OK HEE , Lee Young Hun , Park Byung-Hyun , Lee Ju-Seog 
Published: January 2024

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide, with more than 800,000 deaths each year, and its five-year survival rate is less than 12%. The role of the HN1 gene in HCC has remained elusive, despite its upregulation in various cancer types. In our investigation, we identified HN1’s heightened expression in HCC tissues, which, upon overexpression, fosters cell proliferation, migration, and invasion, unveiling its role as an oncogene in HCC. In addition, silencing HN1 diminished the viability and metastasis of HCC cells, whereas HN1 overexpression stimulated their growth and invasion. Gene expression profiling revealed HN1 silencing downregulated 379 genes and upregulated 130 genes, and suppressive proteins associated with the lipogenic signaling pathway networks. Notably, suppressing HN1 markedly decreased the expression levels of SREBP1 and SREBP2, whereas elevating HN1 had the converse effect. This dual modulation of HN1 affected lipid formation, hindering it upon HN1 silencing and promoting it upon HN1 overexpression. Moreover, HN1 triggers the Akt pathway, fostering tumorigenesis via SREBP1-mediated lipogenesis and silencing HN1 effectively curbed HCC tumor growth in mouse xenograft models by deactivating SREBP-1, emphasizing the potential of HN1 as a therapeutic target, impacting both external and internal factors, it holds promise as an effective therapeutic strategy for HCC.
Wear simulation analysis and prediction of cast aluminum alloy material based on ring and block geometric model
Authors: Qin Gan Lin , Wang Hongding , Ma Zhonglei , Liu Hong , Li Zhengning , Yao Yacheng 
Published: January 2024

Abstract
Cast aluminium alloy pistons are widely used in engines, and their wear significantly affects their service life. The finite element simulation analysis approach can accurately predict the amount of wear, reducing product development and production time. This study investigated the wear resistance by incorporating alumina reinforcing particles into the cast aluminium alloy matrix. The friction coefficient was measured using the MM-200 friction and wear testing equipment, and the wear rate was estimated after introducing alumina particles with varying contents into the aluminium alloy matrix. It was found that the cast aluminium alloy with a particle concentration of 2 wt% exhibited the lowest wear rate. A realistic finite element model of ring block friction and wear was developed based on Archard's theory, and wear simulations were conducted for cast aluminium alloys with different particle concentrations. By comparing the experimental and simulated wear scar widths, it was observed that the simulation findings closely matched the experimental data, demonstrating the accuracy of the finite element model. Additionally, the long-term wear behavior of various particle reinforced cast aluminium alloys was predicted by extending the wear simulation duration, revealing the wear characteristics of these alloys with different particle concentrations.
Sub-Nyquist SAR Imaging And Error Correction Via Optimization-based Algorithm
Authors: Chen Wenjiao , Zhang Li 
Published: January 2024

Abstract

Sub-Nyquist synthetic aperture radar (SAR) based on pseudo-random time-space modulation has been proposed to increase swath width while preserving the azimuthal resolution. Due to the sub-Nyquist sampling, the scene can be recovered by the optimization-based algorithm. However, these methods suffer from some issues, e.g., manually tuning difficulty and pre-definition of optimization parameters, and low signal-noise-ratio (SNR) resistance. To address these issues, a reweighted optimization algorithm named pseudo-Λ0-norm optimization algorithm is proposed for the sub-Nyquist SAR system in this paper. A modified regularization model is first built by applying the scene prior information to nearly acquire the number of non-zero elements based on Bayesian estimation, and then this model is solved by the Cauchy-Newton method. Additionally, an error correction method combined with our proposed pseudo-Λ0-norm optimization algorithm is also present to eliminate defocusing for the motion-induced model. Finally, experiments with simulated signals and strip-map TerraSAR-X images are carried out to demonstrate the effectiveness and superiority of our proposed algorithm.