bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pathogenic mutations of APOA5 in Chinese patients with hyperlipidemic acute pancreatitis
Authors: Liu Yuxin , Dai Si , Qin Shuqi , Zhou Jing , Wang Zhendan , Yin Guojian 
Published: November 2023

Abstract
Background and aims:
To study the role of gene mutations in the development of severe hypertriglyceridemia in patients with hyperlipidemic acute pancreatitis (HLAP), especially different APOA5 mutations.
Methods:
Whole exome sequencing was performed on 163 patients with HLAP and 30 patients with biliary acute pancreatitis (BAP). The products of pathogenic mutations in APOA5were visualized using software simulations. The clinical data of the patients were also collected and analyzed.
Results:
1. Compared with BAP patients, pathogenic mutations of APOA5 were frequent in HLAP patients; among them, heterozygous mutation of p.G185C was the most common.
2. All six pathogenic mutations of APOA5 identified in this study (p.S35N, p.D167V, p.G185C, p.K188I, p.R223C, p.H182fs) were positively correlated with severe hypertriglyceridemia; they were all in the important domains of apolipoprotein A-V (apoA-V). p.R223C has the potential to be one of the most deleterious mutations to apoA-V, considering the specific position of residue 223 and the altered amino acid property.
3. Four new APOA5 mutations were identified, namely c.563A>T, c.667C>T, c.788G>A and c.544_545 insGGTGC.
Conclusions:
The pathogenic mutations of APOA5 were specific to the HLAP patients with severe hypertriglyceridemia in China, and identifying such mutations had clinical significance in elucidating the etiology and subsequent treatment.
A New Workflow for the Effective Curation of Membrane Permeability Data from Open ADME Information
Authors: Esaki Tsuyoshi , Yonezawa Tomoki , Ikeda Kazuyoshi 
Published: November 2023

Abstract
Membrane permeability is an in vitro parameter that represents a compounds apparent permeability (Papp) and is one of the key ADME parameters in drug development. Caco-2 cell lines are the cell lines most commonly used to measure Papp. Other cell lines, such as the Madin-Darby Canine Kidney (MDCK), LLC-Pig Kidney 1 (LLC-PK1), and Ralph Russ Canine Kidney (RRCK) cell lines, have also been used to estimate Papp. Therefore, constructing in silico models to estimate Papp using the MDCK, LLC-PK1, and RRCK cell lines is necessary. Collecting extensive amounts of in vitro Papp data using these cell lines is crucial to construct in silico models. An open database helps in the collection of extensive measurements of various compounds covering a vast chemical space; however, concerns have been reported on the use of data published in open databases without checking their accuracy and quality. We developed a new workflow supporting for automatic curating Papp data measured in the MDCK, LLC-PK1, and RRCK cell lines collected from ChEMBL using KNIME. The workflow consisted of four main phases. Data were extracted from ChEMBL and filtered to identify the target protocols. A total of 1680 high-quality entries were retained after checking 436 articles. As a result, the cost of building highly accurate predictive models has been significantly reduced by automating the collection of reliable measurement data. The workflow is freely available, can be easily updated by anyone, and has high reusability. Our study provides an opportunity for researchers to analyze data quality and accelerate the development of helpful in silico models for effective drug discovery.
Construction and application of coal seam roof stability evaluation model based on AHP-entropy weight TOPSIS method
Authors: Huo Bingjie , Xia Pingchuan , JIN Jingjue , Li Tao , ZHANG Songtao 
Published: November 2023

Abstract
In order to evaluate the stability of the roof of a coal seam accurately and reliably, a TOPSIS evaluation model of the stability of the immediate roof a coal seam, combined with the AHP method and entropy weight method, was developed. Ten (10) commonly used evaluation indices are selected to establish the index system for evaluating the stability of the immediate roof of the coal seam. The AHP and entropy weighting methods combine subjective and objective weightings of the thirty (30) field data sets from a mine in Inner Mongolia. The most important indicators affecting the stability of the immediate roof of the coal seam are the lithology combination of the roof and the strength of he roof combination. The TOPSIS method calculates and scores the weighted evaluation matrix to assess the degree of stability of the immediate roof of 30 groups of field data. The results show that the AHP-entropy weight TOPSIS model, combining subjective and objective weighting and multi-level combination, can be used to analyse the stability of the immediate roof of the coal seam. The evaluation results are better than those of the AHP and entropy weight TOPSIS model. The combination weighting method improves the precision of the TOPSIS model evaluation. The research results can help control rocks surrounding the roadway, the selection of support equipment and the choice of parameter.
Synthesis of silver nanoparticles from oleander using a green method, and their application in enhancing photocatalytic degradation of MB with TiO2 &amp;CuO Nanocomposite
Authors: Shawky Amira M. , Elshypany Rania , Sharkawy Heba M. El , Mubarak Mahmoud F. , Selim Hanaa 
Published: November 2023

Abstract
The tertiary composite of TiO2/CuO @ Ag (TCA) were synthesized by the solid state method using different ratios of TiO2/CuO NCs and Ag NPs. The structural, morphological, and optical properties of nanocomposites were analysed by scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), Raman spectroscopy, UV–Vis diffuse reflectance spectra (UV–Vis/DRS) and Photoluminescence (PL) spectrophotometry. The results showed enhanced activity of TCA hybrid nanocrystals in oxidizing MB in water under visible light irradiation compared to pure TiO2. The photocatalytic performance TCA samples increased with suitable Ag content. The results show that the photo degradation efficiency of the TiO2 compound improved from 13% to 85% in the presence of TiO2-CuO and to 98.87% in the presence of Ag containing TiO2-CuO, which is 7.6 times higher than that of TiO2. Optical characterization results show enhanced nanocomposite absorption in the visible region with long lifetimes between e/h+ at optimal TiO2-CuO/Ag (TCA2) ratio. Reusable experiments indicated that the prepared TCA NC photo catalysts were stable during MB photodegradation and had practical applications for environmental remediation.
Interpersonal activity knowledge graph for organizations
Authors: SOUNCHIO Serge SONFACK , HALGUIETA Trawina , NGUEKEU Baudelaire Ismael TANKEU , GENESTE Laurent , KAMSU-FOGUEM Bernard 
Published: November 2023

Abstract
Knowledge is essential for organizations' growth, allowing them to solve problems, make decisions, innovate, and stay competitive. Within organizations, there is, on the one hand, explicit knowledge that is easy to capture, represent, and share. On the other hand, there is tacit knowledge possessed and acquired by individuals during their activities, which, unlike explicit knowledge, is difficult to capture, formalize, store, or share within organizations. However, organizations have granted more interest and effort in representing, sharing, and reasoning from explicit knowledge. Nevertheless, to access tacit knowledge, organizations rely on methods such as meetings, mentoring, question answering, or interviews, which are not efficient for personal know-how within organizations.
This study elaborates on the construction of interpersonal activity graphs from semantic web perspectives to represent, share, and reason from organizations' knowledge possessed by individuals regarding their activities. The established activity-centered graph is based on an extension of the activity theory framework. This representation captures the knowledge of persons regarding their activities in a graph form, making it understandable and shareable while offering means to reason and query it.
Petrogenesis and tectonic setting of late Permian–Early Triassic granitic rocks in the western Qaidam Basin, Qinghai–Tibetan Plateau
Authors: Gao Wanli , Wang Zongxiu , Jiang Wan 
Published: November 2023

Abstract
Occurring after the early Palaeozoic collisional orogeny and continental deep subduction, late Palaeozoic tectonic magmatism in the northern Qaidam Tectonic Belt (NQTB) related to the Palaeo-Tethys Ocean has become a critical issue. We performed a detailed geochronological and geochemical study of Lenghu (LH) granitic rocks in the western NQTB to obtain better constraints on the subduction processes of the Palaeo-Tethys Ocean in the northern Qinghai–Tibetan Plateau. LA–ICP–MS U–Pb dating of zircons from LH granitic rocks in the western NQTB yields emplacement ages of 253 ± 4 Ma and 264 ± 4 Ma, indicating a two-stage emplacement process. Geochemical analyses show that both the late Permian and Early Triassic granitic rocks have low A/CNK and A/NK values and are enriched in LILEs (Rb, Th, Ba, Zr, and Hf) and depleted in HFSEs (Sr, P, Ti, Nd, and Ta). The SREE contents range from 36 to 189 ppm, and the samples are enriched in LREEs (LREE/HREE =1.5–7.3). Values of (La/Yb)N range between 0.9 and 6.5, and all samples show negative Eu anomalies (δEu =0.2–0.6), with typical characteristics of island arc magmatism. The two-stage granitic rocks have εHf(t) values of -3.7 to +8.0 and yield a two-stage depleted mantle Hf model age of 1.51-0.78 Ga. The data suggest that the late Permian–Early Triassic granitic rocks were derived from partial melting of Proterozoic crust-related mafic to intermediate rocks with significant crust–mantle interactions. The results, combined with regional magmatic information, indicate that the South Kunlun Oceanic plate might have experienced plate rollback in the late Permian and plate retraction in the Triassic under the Kunlun–Qaidam Block.
Rapid Intensification of Typhoon Haiyan 2013: Atmospheric and Climatological Analysis using Open-source Data
Authors: Dasallas Lea , Lee Seungsoo 
Published: November 2023

Abstract
Typhoon Haiyan 2013, one of the most powerful typhoons in the Western North Pacific (WNP) Basin, had undergone rapid intensification (RI) before landfall, resulting to destructive storm surges in the southeastern part of the Philippines. This research aims to investigate the environmental conditions that had led to the intensification, through the use of open-source meteorological and climatological data. Observed and long-term averaged values of sea surface temperature (SST), vertical windshear (VWS), mid-tropospheric relative humidity (MTRH), and mean sea level pressure (MSLP) were compared and analyzed. Additionally, the roles of climate variations such as the El Niño-Southern Oscillation (ENSO), the Quasi-biennial Oscillation (QBO) and the Madden-Julian Oscillation (MJO) were also investigated. Results indicate that the intensification was triggered by higher-than-average SST, weak VWS for 1000 − 500 hPa and 850 − 700 hPa levels, and high and increasing MTRH. Findings also imply that the WNP Subtropical High appeared to be strong during the event, ENSO was in neutral phase, QBO was in favorable westerly phase, and MJO was leaning towards its ending phase in the Pacific. This research demonstrates the collaborative use of open-access data for meteorological and climatological analysis, enabling a better understanding of weather extremes, facilitating more accurate predictions in the future.
Catastrophic Basilar Artery and Superior Cerebellar Stroke in a 28 year old Female – Case Report
Authors: Ahmad Ihsaan , Enea Kristine , Rosenthal Johanna 
Published: November 2023

Abstract
Background
This report highlights details of a posterior fossa stroke case with the aim of improving efforts in recognition and early goal directed management of this potentially deadly condition.
Case presentation:
A 28-year-old female with morbid obesity (BMI over 60) was transferred from an outside hospital for a suspected posterior stroke. Her last known normal was eight hours prior, when she started to feel hot, lethargic, nauseated, and began vomiting. Early NCCT and CTA were difficult reads while the CTP was negative in what was later to be determined to be a basilar and superior cerebellar artery ischemic stroke. Note, an MRI was not able to be obtained due to the patient’s large body habitus. A head CT thirty hours after symptom onset, displayed significant ischemic changes with a suspected transforaminal herniation.
Conclusions
A negative CTP study and inability to obtain an MRI lead to delays in potential life saving procedures; guidelines in this realm could benefit future management of patients with suspected posterior circulation strokes when imaging modalities are either non-diagnostic or unattainable.
Causal relationship between gut microbiota and malignant lymphoma:a two-way two-sample Mendelian randomization study
Authors: Shixue Laoguo , Xiaoyu Xu , Ning Mo , Jing Tang , Yanfeng Jiang , Xianye Huang , Shanlin Duan , Weizhen Wu , Hening Li , Jie Ma 
Published: November 2023

Abstract
Background
The significance of gut microbiota in human health is gaining attention, leading to a rise in observational and clinical studies focused on understanding the factors and mechanisms that influence gut microbiota in various malignancies, such as lymphoma.However, the precise causative link between the gut microbiota and malignant lymphoma remains uncertain.In recent times, the employment of Mendelian randomization(MR) analysis in investigating the gut microbiota has demonstrated substantial scientific merit in uncovering the association between the intestinal microbiota and various diseases. Moreover, the utilization of MR analysis holds promise in elucidating the causative link that exists between the gut microbiota and lymphoma.
Materials and methods
Bidirectional two-sample MR analysis was used to examine the causal relationship between malignant lymphoma and gut microbiota. The summary of gut microbiota statistics used in this study came from a large-scale genome-wide MiBioGen consortium project involving 18,340 subjects from a multi-ethnic group. Summary statistics for malignant lymphoma were obtained from the OPEN GWAS website with the participation of 490,803 European subjects. According to the inclusion standard screening single nucleotide polymorphism (SNP) as a tool variable (IV), the potential causative link between gut microbiota and malignant lymphoma was examined by inverse variance weighting method, MR-Egger method, weighted median method, weighted model method and simple mode method. Then, reverse MR analysis was performed on bacteria found to be causally related to malignant lymphoma in forward MR analysis.
Results
In this study, seven causal relationships between intestinal microbiota and malignant lymphoma were determined by five MR analyses, phylon Bacteroidetes (odds ratio (OR) = 1.31,95% CI = 1.02–1.68,P = 0.032),class Bacilli(OR = 1.22 ,95% CI = 1.00-1.49,P = 0.048),family Rikenellaceae(OR = 1.27 ,95% CI = 1.04–1.55,P = 0.022),genus Eubacterium nodatum group(OR = 1.13 ,95% CI = 1.00-1.27,P = 0.046),genus Oxalobacter(OR = 1.23 ,95% CI = 1.06–1.43,P = 0.006),genus Parabacteroides(OR = 1.41 ,95% CI = 1.41–1.99,P = 0.049), there was a causal relationship between the genus Sellimonas(OR = 1.18 ,95% CI = 1.03–1.35,P = 0.016) and malignant lymphoma, and no significant level pleiotropy and heterogeneity were found in the instrumental variables. It should be noted that there is no reverse causality between malignant lymphoma and gut microbiota.
Conclusion
This investigation delved into a plausible causal connection between the gut microbiota and malignant lymphoma. It presents a novel concept and theoretical foundation for future research on the intestinal flora's relationship to lymphoma.
Optimal charging station placement for autonomous robots in drinking water networks
Authors: Castro-Gama Mario , Hassink-Mulder Yvonne 
Published: November 2023

Abstract

Drinking water utilities and commercial vendors are developing battery-powered autonomous robots for the internal inspection of pipelines. However, these robots require nearby charging stations next to the pipelines of the water distribution networks (WDN). This prompts practical questions about the minimal number of charging stations and robots required. To address the questions, an integer linear programming optimization is formulated, akin to set covering, based on the shortest path of the charging stations to each node along a pipeline. The optimization decisions revolve around designating nodes as charging stations, considering the maximum distance (δmax) at which a robot can cover a hard constraint. For optimal placement, two objective formulations are proposed: (i) minimize the total number of stations, representing total cost; and (ii) maximize the total redundancy of the system. The methodology is applied to three WDN topologies (i.e. Modena, FiveReservoirs, and E-Town). Results show the influence of topology on the total number of stations, the number of robots, and the redundancy of the charging stations network. A trade-off between δmax and total number of stations emphasizes robot battery capacity's significance.
Analytical and numerical solutions of radially symmetric aquifer thermal energy storage problems
Authors: Birhanu Zerihun Kinfe , Kitterød Nils-Otto , Krogstad Harald E. , Kværnø Anne 
Published: November 2023

Abstract

Aquifer thermal energy storage (ATES) systems offer reduced energy costs, lower carbon emissions, and increased energy resilience. The feasibility, however, depends on several factors and usually require optimization. We study an ATES system with injection and extraction wells (cf. graphical abstract). The purpose of the investigation was to calculate the recovery factor of an ATES system with a cyclic repetition of injection and pumping. In the paper, we discuss analytical and numerical radial solutions of differential equations for heat transport in water-saturated porous media. A similar solution was obtained for a 2-D-horizontal confined aquifer with a constant radial flow. Numerical solutions were derived by using a high-resolution Lagrangian approach suppressing spurious oscillations and artificial dispersion. The numerical solution and the analytical solutions give consistent results and match each other well. The solutions describe instantaneous and delayed heat transfer between fluid and solid, as well as time-varying water flow. In hydrological terms, these solutions are relevant for a wide range of problems where groundwater reservoirs are utilized for extraction and storage (namely, irrigation; water supply; geothermal extraction).
Estimating IDF curves under changing climate conditions for different climate regions
Authors: Gül Burak , Kayaalp Necati 
Published: November 2023

Abstract

Although climate models can highlight potential shifts in intensity–duration–frequency (IDF) curves, their limited geographical and temporal resolutions limit their direct use in predicting sub-daily heavy precipitation. To use global or regional model outputs to predict urban short-term precipitation, approaches that give the requisite level of spatial and temporal downscaling are required, and these processes remain one of the difficulties that have demanded intensive effort in recent years. Although no novel methods are given in this work, there are few studies in the literature that investigate the impact of climate change on the analysis and design of infrastructure-related engineering structures. Therefore, the purpose of this research is to determine the potential changes in IDF curves because of climate change. The equidistance quantile matching method was used to turn future rainfall forecast data from global climate models (HadGEM2-ES, MPI-ESM-MR, and GFDL-ESM2M) corresponding to RCP4.5 and RCP8.5 scenarios into standard duration rainfall data, and new IDF curves were generated. These IDF curves corresponded very well with those generated from observed data (R2 ≈ 1). The HadGEM2-ES model predicts up to a 25% rise in rainfall intensity, whereas the other two models expect up to a 50% drop.
Experiences from integrating water and sanitation safety planning in small systems in rural Serbia
Authors: van den Berg Harold , Rickert Bettina , Lock-Wah-Hoon Jerome , Jovanovic Dragana , Bijelovic Sanja , Gligorijevic Snezana , Karadzic Vesna , Vasic Milena , de Roda Husman Ana Maria 
Published: November 2023

Abstract
The WHO recommends a risk management approach to ensure safe drinking-water and sanitation, so-called Water Safety Planning and Sanitation Safety Planning. However, applying these risk management approaches separately in small-scale drinking-water supply and sanitation systems might be challenging for rural communities with limited human, financial, and administrative resources. An integrated approach seems a better option. In this study, an integrated water and sanitation safety planning (iWSSP) approach was developed together with guidance and training material for the practical application of this novel approach. The integrated approach was piloted in three small systems in rural Serbia to identify benefits and suggestions for improvement which can be used for potential future scaling-up. Implementing iWSSP at the pilot sites contributed to a better understanding of both drinking-water supply and sanitation systems. It also resulted in increased awareness, knowledge, and understanding among staff of drinking-water supply and sanitation services. Key experts, including external facilitators, played a crucial role in the implementation of iWSSP. Future scaling-up of the integrated approach could be enabled if more guidance, easy-to-use training materials and templates become available which can be adapted and updated as needed.
Assessment of the water content of the soil and utilization of the energy balance model to promote environmentally friendly development of green, low-carbon industries
Authors: Xiang Qianhe 
Published: November 2023

Abstract
The use of energy balance models to study the water content of soil can effectively solve some problems in agricultural production, ecosystem management, and environmental management. The application of the energy balance model requires a large amount of data, and its application in agricultural production is proposed mainly for the prediction and evaluation of the water content of the soil. Various water content values of the soil were determined using an energy balance model and an oven-drying method. The natural water content of the sandy soil determined by oven drying was between 30% and 40% for the sample soil from the same batch, with the second sandy soil sample having the highest value of 39.2% and the 15th sandy soil sample having the lowest value of 30.3%. The natural water content of sandy soils determined using an energy balance model was between 30% and 35%, among which the natural water content of the fifth sandy soil sample was the lowest at 30.12% and the natural water content of the third sandy soil sample was the highest at 34.46%.