bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aptamers based targeted drug delivery system: A newer trend in cancer treatment therapy
Authors: Dey Paramita , Ghosh Anushmita , Sarker Subhrajit 
Published: February 2024

The investigation of targeted drug delivery systems as a way to improve therapeutic efficacy while minimizing adverse effects is a result of the development of novel cancer treatment strategies. This subject explores the exciting field of aptamer-based targeted drug delivery systems for the treatment of cancer. Short single-stranded DNA or RNA molecules called aptamers have a remarkable capacity to bind to particular target molecules with high specificity and affinity. Aptamers have drawn attention as excellent possibilities for creating targeted drug delivery systems by taking use of their special characteristic. The applications, choice, and modification of aptamers to precisely identify cancer-associated biomarkers, such as receptors overexpressed on cancer cells, are covered in detail in this topic. Additionally, it emphasizes various techniques for aptamer-drug conjugation optimization which ensure effective carrier delivery and regulated drug release inside the tumor microenvironment. It is investigated if aptamer-based systems have the ability to overcome problems such drug resistance, heterogeneity, and insufficient drug penetration within solid tumors.In conclusion, this article illuminates how aptamer-based targeted drug delivery systems have transformed the world of cancer treatment. It advances knowledge of these systems and their potential to transform cancer treatment by providing insights into design principles, delivery systems, and therapeutic results.
Bio-markers of immuno-oncology
Authors: Patel Tulsi Dipakbhai , Gunjan  , Vanteddu Venkata Gangadhar 
Published: February 2024

Since its inception until the rapid advancements, the immuno-oncology (I-O) landscape has undergone significant modifications. Thousands of possible I-O medicines and therapy combinations are being tested in clinical trials as part of the current drug development pipeline. Suppose these assets are to be developed effectively and successfully. In that case, it is necessary to invest in and use the proper techniques and technology to speed up the transition from preclinical evaluation to clinical development. These tools, which include suitable preclinical models, pharmacodynamics-related biomarkers, prediction and monitoring capabilities, and developing clinical trial designs, enable quick and effective evaluation during the development process.The possibility of new findings and insights in each of these three areas to further address the clinical care needs of patients with cancer.These tools include. 1. Appropriate preclinical models, 2. Biomarkers of pharmacodynamics, predictive and monitoring utility, and. 3. Evolving clinical trial designs allow rapid and efficient evaluation during the development process.This article provides an overview of how novel discoveries and insights into each of these three areas have the potential further to address the clinical management needs of patients with cancer.
Measuring Personality Development in the Aftermath of Critical Life Events: A Preliminary Longitudinal Mixed Methods Study
Authors: Kaźmierczak Izabela 
Published: February 2024

This article aims to conceptualize, operationalize, and empirically validate the concept of actual personality development in the aftermath of a Critical Life Event. Two qualitative tools have been elaborated: the Structured Critical Life Events Interview and the Coding System for Personality Development. They were empirically verified in a preliminary longitudinal mixed methods study (N = 40 participants, n = 1440 narratives) with three measurements in one year referring to the Transition Cycle (Hopson & Adams, 1976). For assessing reliability the Intraclass Correlation Co­efficient (ICC) and Cronbach’s α were assessed. The convergent validity of the tools was deter­mined by correlating the results with (1) linguistic structure of participants’ verbalizations and (2) the questionnaires measuring similar behaviours and features. The research showed good psycho­metric properties of the tools. Moreover, they better identified personality growth and the specific dynamics of personality changes (positive and negative) than the Post-traumatic Growth Inventory (Tedeschi & Calhoun, 1996).
Correlates of Zero-Dose Status among Children Aged 12–23 Months in the Luambo Health District, Democratic Republic of Congo: A Matched Case-Control Study
Authors: Ntambue Esperent Malu , Magazani Alain Nzanzu , Kasonga Jean Bosco , Mudipanu Adèle , Kabamba Nzaji Michel , Ishoso Daniel Katuashi , Nkamba Dalau Mukadi 
Published: February 2024

(1) Background: “Zero-dose” (ZD) refers to a child not receiving any doses of the pentavalent (diphtheria-tetanus-pertussis-Haemophilus influenzae type b (Hib)-Hepatitis B) vaccine in the routine national immunization schedule. These children are vulnerable to vaccine-preventable diseases (VPDs), and are often already disadvantaged due to poverty, conflict, and lack of access to basic health services. The Luambo health district (HD) is one of the 26 HDs in the Kasai Central Province and has the largest number of ZD children. This study was conducted to examine the factors associated with ZD status in the Luambo HD; (2) Methods: We conducted a mixed study of children aged 12-23 months in the Luambo HD in the Kasai Central Province; (3) Results: A total of 445 children aged 12-23 months were included in the study, including 89 cases and 356 controls. Correlates of zero dose (ZD) status in children aged 12-23 months were mothers who were not receiving Antenatal Care (ANC), of not knowing any VPD, the fact of the children being born in Angola and the fact of the children being born at home. In addition, the perceptions of children’s parents influenced child immunization; (4) Conclusions: Missing ANC services during pregnancy leads to home delivery with consequences being lack of knowledge on childhood’s VPD and subsequently children not being vaccinated.
The Catcher in the Rye y la escritura terapéutica: análisis de dos traducciones al español (Carmen Criado, 1978; 2006)
Authors: García Serrano Ana Isabel 
Published: February 2024

Resumen: The Catcher in the Rye (1951) de J. D. Salinger es un clásico tanto de la literatura estadounidense como de la universal. Hasta el momento, las dos únicas traducciones al castellano publicadas en España son las realizadas por Carmen Criado en 1978 y 2006. Teniendo en cuenta el hecho de que uno de los aspectos de la novela más analizados es la posible idea de que Holden relata la historia como terapia, el objetivo del presente artículo es, por tanto, analizar hasta qué punto la novela original parece contener una finalidad terapéutica y cómo esta posible finalidad ha sido plasmada en ambas traducciones al castellano disponibles en España. El análisis comparativo de ambas traducciones muestra que, pese a que la traducción de 2006 consigue plasmar el estilo coloquial y oral de la novela original de forma más fidedigna, esta mantiene, no obstante, rasgos como la traducción del pronombre “you” de apelación al lector por “ustedes”. Esto disminuye las posibilidades de que los lectores meta, a diferencia de los lectores origen, interpreten que los hechos son narrados como forma de terapia.
Palabras clave: Escritura terapéutica. Teoría de la Relevancia. Estilo coloquial, Apelación al lector. Relevancia y traducción.
Plug Your Way Through Downhole Restrictions
Authors: Wang Jack 
Published: February 2024

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Unable to successfully deploy plug-and-perf bottomhole assemblies (BHA) to the desired depth has resulted in significant nonproductive time (NPT) in unconventional completions. These instances of NPT are primarily attributed to casing deformation, rather than plug presets.
To address these downhole restrictions, frac plugs with smaller outer diameters (OD) were introduced for stage isolation. This reduction in plug OD minimizes the risk of getting stuck in tight spaces, but it also compromises pressure ratings. This raises the risk of skidding (slip losses, anchoring) and leads to increased fluid usage for pumpdown.
These challenges not only risk well productivity, but also escalate completion time and costs. For a comprehensive solution, a smaller-OD frac plug is necessary to pass through tight spots, while maintaining anchoring, sealing, and reducing required pumped-fluid volume.

The Gap
The annular clearance between the plug OD and casing inner diameter (ID) significantly influences plug-and-perf operations. A smaller gap leads to advantages such as lower expansion rates for isolation, better anchoring, and reduced pumped-fluid volume, but it also heightens the risk of obstructions.
Conversely, a larger gap requires higher expansion rates for isolation, resulting in weaker anchoring, lower pressure rating, and increased fluid consumption, but reduces the likelihood of obstructions. In some frac operations, higher pressure is needed to break down the formation; thus, frac plugs with higher pressure ratings (smaller gap) are commonly favored. For instance, in 5.5-in., 20-lb/ft casing, typical frac plugs have an average OD of 4.4 in., an expansion rate of 8–12%, and a pressure rating of 10,000 psi.
In many 5.5-in., 20 lb/ft casedhole completions across the US and parts of China, the annular clearance between casing ID and frac plug OD is approximately 0.2 in. on the x-axis and 0.4 in. on the y-axis (Fig. 1). In this confined space, encountering debris, sand accumulation, or a deformed section during pumpdown can obstruct or fully trap the plug. To mitigate these uncertainties, smaller-OD plugs are used for such “emergency” scenarios.
Smaller-OD plugs have improved chances of navigating through tight spots, but they necessitate higher expansion rates for isolation, resulting in lower pressure ratings. For example, in 5.5-in., 20 lb/ft casing, reduced OD plugs have an average OD of 3.8 in., an expansion rate of 20–25%, and a pressure rating of 5,000 psi. They are more likely to fail due to their pressure limitations and use more fluid for pumpdown.
In cases where the use of normal-OD plugs is not feasible, opting for smaller-OD plugs, even though they might have a higher risk of failure, can be a valuable last resort. This approach is sometimes favored over entirely skipping the problematic stages without any form of stimulation.
Dynamic Simulation Platform Aids Deep Transient Tests, Well-Control Safety
Authors: Carpenter Chris 
Published: February 2024

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 215454, “Enhancing Well-Control Safety With Dynamic Well-Control Cloud Solutions: Case Studies of Successful Deep Transient Tests in Southeast Asia,” by M. Ashraf Abu Talib, SPE, M. Shahril Ahmad Kassim, and Izral Izarruddin Marzuki, SPE, Petronas, et al. The paper has not been peer reviewed.

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The complete paper addresses challenges related to well control and highlights the successful implementation of deep transient tests (DTT) in an offshore well performed with the help of a dynamic well-control simulation platform. The paper aims to provide insights into the prejob simulation process, which ensured a safer operation from a well-control perspective. Additionally, a comparison between simulated and actual sensor measurements during the DTT operation is presented.

DTT
DTT is a formation-testing (FT) method that allows pressure transient tests that reach deeper into the formation compared with conventional interval pressure transient tests (IPTT). DTT enables the testing of formations with higher permeability, greater thickness, and lower viscosity and real-time measurement of crucial parameters. During a DTT, formation fluid is pumped from the reservoir; upon stopping the pump, the formation pressure begins to recover as fluid further from the wellbore replaces the extracted fluid. By analyzing the resulting pressure transient, properties such as formation permeability, permeability anisotropy, and other characteristics can be determined. DTT allows for a better understanding of reservoir characteristics and rock heterogeneity. When properly designed and executed, DTT can reveal potential baffles and boundaries within the radius of investigation. A further advantage of DTT over drillstem tests (DST) is its minimal fluid flow, which allows for the attainment of objectives while contributing to the United Nations sustainable development goals.
In DTT operations, the FT tool is connected to the drillpipe through a circulating sub and a slip joint. The circulating sub plays a critical role in DTT operations because it enables the continuous mixing of pumped formation fluid with circulated mud and facilitates its transportation to the surface (Fig. 1). Typically, a constant circulation rate ranging from 100 to 250 gal/min is maintained. During circulation, the annular preventer is closed and the mud/hydrocarbon mixture is directed through the choke line to the mud/gas separator (MGS) once it reaches the surface. No formation fluids are flared during DTT operations. Instead, the circulated oil is retained in the mud and only small amounts of gas are vented. By use of a slip joint, the FT remains anchored to the borehole wall.
A high-resolution pressure gauge is used to capture and interpret even minor pressure fluctuations during the pressure transient buildup.
Fine-Scale hydrodynamic modelling of Lake Ontario: Has climate change affected circulation patterns?
Authors: Hlevca Bogdan , Howell Todd , Madani Mohammad , Benoit Nadine 
Published: February 2024

Abstract

The circulation in Lake Ontario is well known from past field and modelling studies. However, apparent changes in wind patterns, possibly due to climate change, have resulted in subtle changes in the currents’ formation that have implications for water resources and aquatic habitat. A high-resolution three-dimensional numerical model using the Danish Hydraulic Institute’s (DHI) MIKE 3 modelling framework based on a flexible mesh, was developed to describe lake-wide and coastal circulation features in 2018, which were then contrasted with past studies. The validated model effectively described lake-wide processes that include season-specific large gyres in the Rochester and Mississauga basins, and coastal currents along both northern and southern shorelines. During the isothermal season (non-stratified), a well-defined westward flow in the middle of the lake separates an anticyclonic (clockwise) gyre in the north, from the gyre and westward currents in the south. During the stratified season, key physical processes depicted in the model in the offshore and nearshore waters, including near-inertial waves (~17 h), upwelling events frequency (5–10 days), and surface seiches (~5 h) generally correspond with past studies. Upwelling events are the predominant northern nearshore physical processes, occurring during periods of south-westerly winds. Episodic Kelvin waves are mostly limited to the northern shore where wind direction and morphology can sustain them, and where cross-shore transport at the coastal boundary layer is minimal. The results, backed by field observations, suggest that predominant circulation patterns in the northern nearshore have changed in recent years during the stratified season.
A scoping review of interventions intended to reduce publication bias in randomised trials
Authors: Hohflfeld Ameer Steven-Jorg , Kredo Tamara , Clarke Michael 
Published: February 2024

Abstract

Background
The World Health Organization recommends that a randomised controlled trial (RCT) publishes its results in a peer-reviewed journal within 24 months of study completion. When RCTs are not published or publication is delayed, this is publication bias. There is uncertainty about which interventions best mitigate publication bias. This review systematically synthesises literature on interventions targeting researchers to reduce publication bias among health science researchers.
Methods
We conducted a comprehensive search in PubMed and Scopus, and forward and backward citation searches. There were no restrictions on language, time or publication status. We included studies of any design that tested an intervention to reduce publication bias in health research. Ideally, participants had to be investigators or researchers who had conducted, led or been involved in RCTs. The context was any research institution that conducts research.
Two reviewers independently assessed titles and abstracts for eligibility, followed by duplicate full-text screening and data extraction. One reviewer collated and summarised the extracted data and arranged these using an analytical framework to describe the findings thematically. For quality assurance, a second reviewer checked the data analysis.
Results
Our database search yielded 14,185 records, with 11,754 after de-duplication. Of these, we excluded 11,728 records after title and abstract screening. We assessed 26 full texts for eligibility. One of these met the eligibility criteria. Forward and backward citation searches yielded 57 records, 43 were eligible. We included 44 studies published between 1995 and 2022 that described interventions promoting the publication of health-related research. We identified ten broad interventions that were often used in combination and concentrated on writing manuscripts.
Discussion
This review describes several strategies used to assist researchers in publishing their RCT findings. Despite high rates of publication bias and its substantial impact on research waste, we found no research explicitly targeting interventions to encourage trialists to publish their results. Rigorous research is needed to determine effective strategies for reducing publication bias among trialists.
Competitive binding-mediated mesoscale protein-protein interactions direct microtubule growth
Authors: Wei Zhiyi , Jia Xuanyan , Lin Leishu , Guo Siqi , Zhou Lulu , Jin Gaowei , Dong Jiayuan , Xiao Jinman , Xie Xingqiao , Li Yiming , He Sicong , Yu Cong 
Published: February 2024

Abstract
Microtubule organization in cells relies on targeting mechanisms. CLASP proteins are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we revealed that the C-terminal domain of CLASP2 interacts with a common motif found in several CLASP2-binding proteins. This interaction drives the dynamic localization of CLASP2 to distinct cellular compartments, where CLASP2 accumulates in protein condensates at the cell cortex or the microtubule plus end. These condensates physically contact with each other via CLASP2-mediated competitive binding, determining cortical microtubule targeting. The phosphorylation of CLASP2 modulates the dynamics of the condensate-condensate interaction and spatiotemporally navigates microtubule growth. Moreover, we identified additional CLASP-interacting proteins that are involved in condensate contacts in a CLASP2-dependent manner, uncovering a general mechanism governing microtubule targeting. Our findings not only unveil a tunable multiphase system regulating microtubule organization, but also offers general mechanistic insights into intricate protein-protein interactions at the mesoscale level.
Suppression of the Leidenfrost Phenomenon by Superhydrophilic Graphene Nanobush
Authors: Chen Xue , Wang Kun , Zhu Jiamin , Lu Tao 
Published: February 2024

Abstract

The Leidenfrost phenomenon considerably reduces the heat transfer at high temperatures, but proper micro/nanofabrication can enhance the heat transfer by elevating the Leidenfrost temperature. However, the complicated micro/nanofabrication techniques are difficult to implement in large-scale commercial applications. This paper describes superhydrophilic graphene nanobush (SGNB) on Cu plates prepared by the PECVD method and subsequent air plasma etching that improves the spray cooling heat transfer. The results show that the Leidenfrost temperature of SGNB/Cu plate is up to 240 °C greater than that of a bare Cu surface. The much higher temperature on the SGNB/Cu surface is due to the fast water wicking and spreading by the nanobush superhydrophilicity, as well as increased heat transfer area, increased number of boiling nucleation sites and the robust vapor channels provided by the porous nanobush structure. This study shows the great ability of the nanobush for enhancing the boiling heat transfer and a feasible strategy for suppressing the Leidenfrost phenomenon.
Precursory seismic quiescence of major earthquakes along the Sagaing Fault Zone, Central Myanmar - application of the pattern informatics technique
Authors: Traitangwong Premwadee , Khamsiri Sutthikan , Pailoplee Santi 
Published: February 2024

Abstract

In this study, the precursory seismic activity before a major earthquake was investigated by using the Pattern Informatics (PI) algorithm along the Sagaing Fault Zone (SFZ), Central Myanmar. After improving the earthquake catalogue, the completeness of seismicity data with Mw ≥ 3.6 reported during 1980-2020 was used in retrospective testing to find the suitable parameters of the PI algorithm. According to the retrospective test with 6 cases of different forecast period times related to Mw ≥ 5.0 earthquakes, including verification using the relative operating characteristics (ROC) diagram, the characteristic parameters of both time intervals (change time and forecast time window) = 10 years and target forecast earthquake magnitude Mw ≥ 5.0 are suitable parameters for PI investigation along the SFZ. Therefore, these parameters were applied with the most up-to-date seismic dataset to evaluate the prospective areas of upcoming major earthquakes. The results reveal that the Myitkyina and the vicinity of Naypyidaw might be at risk of a major earthquake in the future. Therefore, effective earthquake mitigation plans should be urgently arranged.
Site-Selective Functionalization of Unactivated C(sp3)–H Bonds via Synergistic Merger of Photoredox and HAT Catalysis
Authors: Li Jianjun , Wang Chaodong , Chen Zhi , Sun Jie , Tong Luwei , Wang Wenjian , Song Shengjie 
Published: February 2024

Abstract

Hydrogen atom abstraction from C(sp3)−H substrates for the generation of alkyl radical represents a desirable yet underexplored strategy in alkylation reaction since involving noble metal catalysts, stoichiometric oxidants, and limited scope are common drawbacks. Here we describe the synergistic utilization of photoredox and hydrogen atom transfer (HAT) catalysis to accomplish a general and practical functionalization of unactived C(sp3)−H centers, which features broad reaction scope, high functional group compatibility, and operational simplicity. A combination of validation experiments and density functional theory reveals that the N-centred radicals, generated from free N−H bond via photoredox catalyzed single-electron oxidation followed by deprotonation in a stepwise electron/proton transfer event, are the key intermediates that enable an intramolecular 1,5-HAT or intermolecular HAT process for nucleophilic carbon-centred radicals formation to achieve heteroarylation, alkylation, amination, cyanation, azidation, trifluoromethylthiolation, halogenation and deuteration. The practical value of this protocol was further demonstrated by the gram-scale synthesis and the late-stage functionalization of natural products and drug derivatives.