bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary metabarcoding of keystone sardine species reveals the importance of their ichthyoplankton prey in food webs of the Southern Brazilian Bight fisheries
Authors: de Queiroz Anna Karolina Oliveira , Gasalla Maria A. , Laux Marcele , Oliveira Renato Renison Moreira , dos Anjos Santa Rosa Fabricio , Schrøder‐Nielsen Audun , Postuma Felippe A. , de Luna Sales João Bráullio , de Boer Hugo J. , Mauvisseau Quentin , Ready Jonathan Stuart 
Published: February 2024

AbstractClupeiform fishes are ecologically and economically important species contributing to industrial and artisanal fisheries worldwide. They represent key links in food webs, influencing the dynamic between trophic levels. The dietary interactions of these species are poorly studied in many regions, yet essential for fisheries management. To elucidate the role of these species in food webs of the Southern Brazilian Bight pelagic fisheries, we used metabarcoding analysis of fish stomach contents of Clupeiformes and possible predators. Onboard sampling from March to September 2016 allowed for processing of 87 stomach samples representing 31 species (including 12 samples representing three species of Clupeiformes). Links between trophic levels showed the predominance of Sardinella brasiliensis and Engraulis anchoita as important dietary items of a large range of fishes (28 species belonging to 18 families) and representing the majority of the total prey read abundance assigned to clupeiform fishes (~46% and ~32%, respectively). Opisthonema oglinum contributed to the diet of 16 species in 13 families and ~18% of total read abundance of clupeiform fishes as prey. The appearance of multiple clupeiform taxa in the diet of predators that are not commonly associated with pelagic prey indicates that ecosystem‐based fisheries management should not be separated between pelagic and demersal fisheries. The diet of Clupeiformes revealed an unexpectedly large diversity of fish species and a low proportion of invertebrates (<5% of clupeiform prey reads). This was likely due to a combination of both a limitation of the metabarcoding method (primer bias and low success of invertebrate taxonomic identification) as well as a contribution of early life stages (ichthyoplankton) to the diet of these fishes. The potential role of clupeiform fish populations as a constraint to the recruitment from the ichthyoplanktonic phase of other ecologically or commercially important fishes should be considered as an important direction for future studies.
“Stories one tells in dark times”: Fabulation, fugitivity, and futurity in Olivia Wenzel's 1000 Serpentinen Angst
Authors: Roca Lizarazu Maria 
Published: February 2024

AbstractThis article engages with aesthetic acts of experimentation in Olivia Wenzel's 1000 Serpentinen Angst. Building on recent scholarship on the politics of aesthetics in Wenzel's text, I argue that these experiments are intertwined with key themes in the book, particularly issues of racialization and of Black (im‐)possibility in present‐day Germany. In this context, my article focuses on a largely overlooked aspect of Wenzel's text, namely its surreal, fantastical, and speculative elements. Drawing on Tavia Nyong'o and Saidiya Hartman's notion of “(critical) fabulation,” I propose that Wenzel's writing mobilizes fantastic, imaginative, and speculative elements to unsettle oppressive realities and realisms in favor of alternative modes of world‐ and future‐making. Inspired by Tina M. Campt's work, I conceptualize these re‐makings as “fugitive” and quotidian strategies, developed in response to a broken world, which still have the potential to generate new infrastructures for relationality and futurity.
Eradication rate and adherence with high‐dose amoxicillin and proton pump inhibitor as first‐line treatment for Helicobacter pylori infection: Experience from University Hospital in Chile
Authors: von Muhlenbrock Christian , Cordova Andrea , Nuñez Paulina , Pacheco Nicole , Herrera Karin , Quera Rodrigo 
Published: February 2024

AbstractIntroductionIn Chile, more than 70% of adults are infected by Helicobacter pylori. Clarithromycin should not be used in any regimen if there is >15% resistance to this antibiotic, being greater than 26% in our population. In this scenario, the effectiveness of triple therapy (proton pump inhibitor [PPI], clarithromycin, amoxicillin) was only 63.8%.AimTo evaluate the eradication rate and safety of dual therapy (esomeprazole and amoxicillin) in high doses, through a prospective, observational, and descriptive study.MethodsPatients with a positive urease test obtained in an upper digestive endoscopy were included. Any other previous H. pylori eradication regimen were excluded. All patients were treated with esomeprazole 40 mg three times a day and amoxicillin 750 mg four times a day for 14 days. The eradication rate of the dual therapy was evaluated with the H. pylori stool antigen test (the Pylori‐Strip® test used) 6 weeks after completing the eradication treatment and with at least 14 days without PPI, being a negative result, confirmation of the effectiveness of this regimen.ResultsOf 122 patients, 106 had a negative H. pylori antigen in stool; The intention‐to‐treat and per protocol analysis, the eradication rates were 91.8% [95% CI: 87%–97%] and 94% [95% CI: 90%–98%], respectively. Four patients discontinued treatment due to adverse effects. Smoking and adherence to treatment were associated with eradication rate.ConclusionsIn this cohort of patients with H. pylori infection, high‐dose dual therapy has a high eradication rate and good adherence, raising the possibility that it could be used as first‐line therapy in our country. Studies with a larger number of patients should confirm these results.
Does targeted recruitment turn the dial for gender equity? A qualitative study at an Australian University
Authors: Lane C. , Saronga N. , Fowell R. , Berretta R. , Blackmore K. , Momenzadeh L. , Giacomini A. , Ware S. , Milam J. 
Published: February 2024

AbstractThis qualitative study explored a targeted recruitment initiative that was designed to attract and recruit female academic staff in STEM disciplines at an Australian University. Semi‐structured, one‐on‐one interviews were conducted with female and male key informants: 16 Panel Members and six Applicants. Codebook Thematic Analysis was applied using a feminist methodological lens. Results showed several themes (categorised as barriers and facilitators) impacting the implementation and success of targeted recruitment. The majority of themes were associated with Panel Members, underpinning the importance of panels' support for targeted recruitment. Nearly all barriers were gender‐related, disadvantaging female applicants and emphasising a need to address gender inequity broadly. Key recommendations for future improvement were strategies to improve the support of panels (e.g., gender bias training, improved communication of responsibilities in targeted recruitment and ensuring an equity and diversity ‘champion’) and efforts to strengthen the positive diversity reputation of the University.
Comparison of patient background between a real‐world North American cohort and the Göteborg‐2 trial
Authors: Chiarelli Giuseppe , Davis Matthew , Stephens Alex , Cirulli Giuseppe Ottone , Finati Marco , Corsi Nicholas J. , Sood Akshay , Tinsley Shane , Carrieri Giuseppe , Briganti Alberto , Montorsi Francesco , Lughezzani Giovanni , Buffi Nicolò , Rogers Craig , Abdollah Firas 
Published: February 2024

ObjectivesTo analyze the generalizability of the Göteborg‐2 findings to a North American cohort.MethodsWe replicated the Göteborg‐2 inclusion criteria in our Henry Ford Health (HFH) cohort, by identifying all patients 50–60 years old who had a PSA test from 2013 to 2018. The first PSA within the study period was considered PSA at entry, and included in the analysis. Chi‐square test was used to compare categorical variables between the Göteborg‐2 and HFH cohort, with a particular focus on Black men, who were also analyzed separately.ResultsThe HFH patients included in the cohort were 49 456, of which 8562 were Black. In patients within the entire HFH cohort, HFH Black cohort, Göteborg Reference cohort, and Göteborg Experimental cohort, the rate of PSA ≥3 ng/mL was, respectively, 6.8%, 10.2%, 6.8%, and 6.6%. The rate of biopsy performed was, respectively, 1.8%, 4.1%, 5.8%, and 2.5%. PCa was found in, respectively, 1.4%, 3.0%, 2.3%, and 1.5%; Gleason score 3 + 3 in, respectively, 0.5%, 0.8%, 1.2%, and 0.6%; Gleason score > 3 + 3 in, respectively, 0.9%, 2.2%, 1.1%, and 0.9%.ConclusionsOur cohort had a lower biopsy rate and a lower incidence of non‐csPCa diagnosis than both Göteborg cohorts, while still maintaining the same incidence of csPCa. This implies that the benefits of reducing non‐csPCa diagnosis, as observed in the Experimental Göteborg cohort, are not necessarily replicable in U.S. “real‐world practice” patients. Also noteworthy, we had a significantly higher percentage of Black men, who showed more aggressive disease.
Bmo‐miR‐6498‐5p suppresses Bombyx mori nucleopolyhedrovirus infection by down‐regulating BmPLPP2 to modulate pyridoxal phosphate content in B. mori
Authors: Cao Hui‐Hua , Kong Wei‐Wei , Chen Xi‐Ya , Ayaz Sadaf , Hou Cai‐Ping , Wang Yi‐Sheng , Liu Shi‐Huo , Xu Jia‐ping 
Published: February 2024

AbstractThe RNA interference pathway mediated by microRNAs (miRNAs) is one of the methods to defend against viruses in insects. Recent studies showed that miRNAs participate in viral infection by binding to target genes to regulate their expression. Here, we found that the Bombyx mori miRNA, miR‐6498‐5p was down‐regulated, whereas its predicted target gene pyridoxal phosphate phosphatase PHOSPHO2 (BmPLPP2) was up‐regulated upon Bombyx mori nucleopolyhedrovirus (BmNPV) infection. Both in vivo and in vitro experiments showed that miR‐6498‐5p targets BmPLPP2 and suppresses its expression. Furthermore, we found miR‐6498‐5p inhibits BmNPV genomic DNA (gDNA) replication, whereas BmPLPP2 promotes BmNPV gDNA replication. As a pyridoxal phosphate (PLP) phosphatase (PLPP), the overexpression of BmPLPP2 results in a reduction of PLP content, whereas the knockdown of BmPLPP2 leads to an increase in PLP content. In addition, exogenous PLP suppresses the replication of BmNPV gDNA; in contrast, the PLP inhibitor 4‐deoxypyridoxine facilitates BmNPV gDNA replication. Taken together, we concluded that miR‐6498‐5p has a potential anti‐BmNPV role by down‐regulating BmPLPP2 to modulate PLP content, but BmNPV induces miR‐6498‐5p down‐regulation to promote its proliferation. Our findings provide valuable insights into the role of host miRNA in B. mori–BmNPV interaction. Furthermore, the identification of the antiviral molecule PLP offers a novel perspective on strategies for preventing and managing viral infection in sericulture.
Cross‐border mobility, inequality and migration intermediaries: Labour migration from Nepal to Malaysia
Authors: Sha Heila , Khor Yvonne 
Published: February 2024

AbstractThis article aims to contribute to labour recruitment policy by demonstrating the relations between cross‐border mobility and inequality through the lens of migration intermediaries. Drawing on thematic analysis of the MIDEQ project's in‐depth interviews with Nepalese labour migrants (n = 20) in Malaysia, this research reveals the range of migration intermediaries along the recruitment chain, and shows contradictory roles played by migration intermediaries: they help migrant workers access employment and other opportunities thus overcoming inequality in mobility, whilst simultaneously reproducing socio‐economic inequalities and the unequal power relations experienced by migrants. Hence, we identify a “middle space effect” that links migration processes with migration outcomes, reconstructing socio‐economic inequalities in mediated migration. We highlight the role of state policies regarding migration and labour in co‐producing such inequalities, and the embeddedness of middle space intermediaries in unequal global power dynamics, and we offer policy suggestions on regulation of labour recruitment and employment.
An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management
Authors: Oropallo Alisha , Rao Amit S. , Del Pin Christina , Ranire‐Maguire Marisa , Mathew Angelin 
Published: February 2024

AbstractCleansing is a vital component of effective wound hygiene and biofilm management, often accomplished through vigorous mechanical action or through soaking with moistened gauze. In the present study, a quantitative comparison of the effectiveness of different cleansing techniques and solutions in removing bacteria was conducted on 71 chronic wounds using bacterial fluorescence imaging as a real‐time diagnostic for moderate to high bacterial loads. Vigorous gauze cleansing for 30 s proved most effective by reducing bacterial fluorescence by 33.99%, surpassing 10‐min soaking in bacterial reduction (13.24%). Among different cleansers, no statistically significant differences in effectiveness were observed, but povidone‐iodine showed the strongest trend towards bacterial reduction. Sub‐analysis highlighted the superiority of antiseptic cleansers over saline and gentle soap (−33.30% vs. −1.80% bacterial reduction respectively). Five percent acetic acid was also shown to be more effective in removing specific bacterial strains (Pseudomonas aeruginosa). Findings from studies like this contribute to refining wound hygiene guidelines and clinical algorithms for bacterial and biofilm management.
Safety and efficacy of combined dilation/stenting of venous abnormalities, including complete obstructions, during lead extractions in patients with congenital heart disease
Authors: Knapp William P. , O'Leary Edward T. , Quinn Brian , Porras Diego , Mah Douglas Y. 
Published: February 2024

AbstractIntroductionManagement of transvenous leads in patients with congenital heart disease (CHD) can be complicated by venous obstructions and residual shunts. We present our experience performing concurrent lead extraction and dilation/stenting of venous pathways, including patients with complete venous obstruction.MethodsAll cases of concurrent lead extraction and recanalization of vena cavae/baffles between 2017 and 2021 at Boston Children's Hospital were retrospectively included and reviewed for safety and efficacy.ResultsEight patients, 4 female, median 38.5 years of age (range 16.7−49 years) and 81.6 kg weight (range 41.3−97.8 kg) at time of procedure were included. All patients had CHD, a majority (n = 7) having transposition of the great arteries palliated via atrial switch. All leads were removed in their entirety, with most patients having two leads extracted (n = 7). Median lead dwell time was 13.8 years (range 3.6−35.3 years). Three patients had complete obstructions, three required stenting of their innominate veins and three required recanalization of their femoral vessels. Median procedure time was 9.8 h (range 5.4−12.8 h). Complications included blood transfusion (n = 2), arrhythmia (n = 3), pleural effusion (n = 1), and pressure ulcer (n = 1). There were no cardiac perforations, venous tears, or deaths.ConclusionLead extraction along with dilation and stenting of venous anomalies, though long in duration, proved effective with minimal complications. This combined procedure can safely and effectively resolve complete obstructions secondary to transvenous leads.
Embedding the service user voice to co‐produce UK mental health nurse education—A lived experience narrative
Authors: O'Brien Sam , Davenport Caroline 
Published: February 2024

Accessible SummaryWhat is known on the subject?

Co‐production aims to value service user voices and is increasingly used in healthcare.

Less is known about how co‐production in nursing education is experienced by service users.

What the paper adds to existing knowledge?

This paper shares the experience of one service user who teaches student nurses in a UK university.

For the first author, the paper highlights that co‐producing nurse education has been valuable and rewarding for both a service user and students.

What are the implications for practice?

Co‐production has the potential to benefit student nurses, including challenging their perceptions of ‘difficult’ patients. To achieve this, teaching sessions must be equally produced and delivered. By employing and including service users, universities have the potential to improve experiences for students and service users alike.

AbstractIntroductionCo‐production is increasingly used in health care but there is less attention to a co‐produced mental health nurse education.AimThis article sought to explore the co‐production experiences of a service user who teaches mental health nurses, alongside the benefits of this to nurse education.MethodsThe article is a lived experience narrative co‐written with a nursing lecturer.ThesisCo‐produced mental health nurse education challenges students' perceptions towards self‐harm and encourages empathy and understanding of service user distress.Implications for PracticeCo‐production has many benefits to nurse education including a positive student experience, and validation of the service user experience to support meaningful recovery.
Effect of amlodipine on the circulating renin‐angiotensin‐aldosterone system in healthy cats
Authors: Garcia Marrero Tatiana M. , Ward Jessica L. , Tropf Melissa A. , Bourgois‐Mochel Agnes , Guillot Emilie , Domenig Oliver , Yuan Lingnan , Kundu Debosmita , Mochel Jonathan P. 
Published: February 2024

AbstractBackgroundSystemic hypertension (SH) is a common cardiovascular disease in older cats that is treated primarily with the calcium channel blocker amlodipine besylate (AML). The systemic effect of AML on the classical and alterative arms of the renin‐angiotensin‐aldosterone system (RAAS) in cats is incompletely characterized.Hypothesis/ObjectivesTo determine the effect of AML compared to placebo on circulating RAAS biomarkers in healthy cats using RAAS fingerprinting.AnimalsTwenty healthy client‐owned cats.MethodsCats were administered amlodipine besylate (0.625 mg in toto) or placebo by mouth once daily for 14 days in a crossover design with a 4‐week washout period. Plasma AML concentrations and RAAS biomarker concentrations were measured at multiple timepoints after the final dose in each treatment period. Time‐weighted averages for RAAS biomarkers over 24 hours after dosing were compared between treatment groups using Wilcoxon rank‐sum testing.ResultsCompared to placebo, AML treatment was associated with increases in markers of plasma renin concentration (median 44% increase; interquartile range [IQR] 19%‐86%; P = .009), angiotensin I (59% increase; IQR 27‐101%; P = .006), angiotensin II (56% increase; IQR 5‐70%; P = .023), angiotensin IV (42% increase; −19% to 89%; P = .013); and angiotensin 1‐7 (38% increase; IQR 9‐118%; P = .015).Conclusions and Clinical ImportanceIn healthy cats, administration of AML resulted in nonspecific activation of both classical and alternative RAAS pathways.
Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter‐, cell type‐specific and chromosome‐ transcriptomic signatures
Authors: Chen Zhiyi , Xu Ting , Liu Xuerong , Becker Benjamin , Li Wei , Xia Lei , Zhao Wenqi , Zhang Rong , Huo Zhenzhen , Hu Bowen , Tang Yancheng , Xiao Zhibing , Feng Zhengzhi , Chen Ji , Feng Tingyong 
Published: February 2024

AimsThis study aimed to illuminate the neuropathological landscape of attention deficit hyperactivity disorder (ADHD) by a multiscale macro–micro‐molecular perspective from in vivo neuroimaging data.MethodsThe “ADHD‐200 initiative” repository provided multi‐site high‐quality resting‐state functional connectivity (rsfc‐) neuroimaging for ADHD children and matched typically developing (TD) cohort. Diffusion mapping embedding model to derive the functional connectome gradient detecting biologically plausible neural pattern was built, and the multivariate partial least square method to uncover the enrichment of neurotransmitomic, cellular and chromosomal gradient‐transcriptional signatures of AHBA enrichment and meta‐analytic decoding.ResultsCompared to TD, ADHD children presented connectopic cortical gradient perturbations in almost all the cognition‐involved brain macroscale networks (all pBH <0.001), but not in the brain global topology. As an intermediate phenotypic variant, such gradient perturbation was spatially enriched into distributions of GABAA/BZ and 5‐HT2A receptors (all pBH <0.01) and co‐varied with genetic transcriptional expressions (e.g. DYDC2, ATOH7, all pBH <0.01), associated with phenotypic variants in episodic memory and emotional regulations. Enrichment models demonstrated such gradient‐transcriptional variants indicated the risk of both cell‐specific and chromosome‐ dysfunctions, especially in enriched expression of oligodendrocyte precursors and endothelial cells (all pperm <0.05) as well enrichment into chromosome 18, 19 and X (pperm <0.05).ConclusionsOur findings bridged brain macroscale neuropathological patterns to microscale/cellular biological architectures for ADHD children, demonstrating the neurobiologically pathological mechanism of ADHD into the genetic and molecular variants in GABA and 5‐HT systems as well brain‐derived enrichment of specific cellular/chromosomal expressions.
Unveiling terahertz wave stress effects and mechanisms in Pinellia ternata: Challenges, insights, and future directions
Authors: Wang Dongdong , Zheng Jiatong , Sarsaiya Surendra , Jin Leilei , Chen Jishuang 
Published: February 2024

AbstractThis review aims to elucidate the intricate effects and mechanisms of terahertz (THz) wave stress on Pinellia ternata, providing valuable insights into plant responses. The primary objective is to highlight the imperative for future research dedicated to comprehending THz wave impacts across plant structures, with a specific focus on the molecular intricacies governing root system structure and function, from shoots to roots. Notably, this review highlights the accelerated plant growth induced by THz waves, especially in conjunction with other environmental stressors, and the subsequent alterations in cellular homeostasis, resulting in the generation of reactive oxygen species (ROS) and an increase in brassinosteroids. Brassinosteroids are explored for their dual role as toxic by‐products of stress metabolism and vital signal transduction molecules in plant responses to abiotic stresses. The paper further investigates the spatio‐temporal regulation and long‐distance transport of phytohormones, including growth hormone, cytokinin, and abscisic acid (ABA), which significantly influence the growth and development of P. ternata under THz wave stress. With a comprehensive review of Reactive oxygen species (ROS) and Brassinosteroid Insensitive (BRI) homeostasis and signalling under THz wave stress, the article elucidates the current understanding of BRI involvement in stress perception, stress signalling, and domestication response regulation. Additionally, it underscores the importance of spatio‐temporal regulation and long‐distance transport of key plant hormones, such as growth hormone, cytokinin, and ABA, in determining root growth and development under THz wave stress. The study of how plants perceive and respond to environmental stresses holds fundamental biological significance, and enhancing plant stress tolerance is crucial for promoting sustainable agricultural practices and mitigating the environmental burdens associated with low‐tolerance crop cultivation.