bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing digital nature for older adults: A mixed method approach
Authors: van Houwelingen-Snippe Josca , Ben Allouch Somaya , van Rompay Thomas J. L. 
Published: December 2023

Objective Loneliness and social isolation are pressing issues that can seriously impact the mental health and well-being of older adults. Interacting with nature can stimulate a feeling of connectedness. However, for older adults, access to nature is often troublesome because of physical limitations and mobility restrictions. Methods In the present mixed-method study, 37 older adults (62–99 years old) with varying care needs and mobility restrictions watched a video presenting a walkthrough of a simulated digital nature landscape. Results Quantitative results show a significant increase in social connectedness scores and enhanced peacefulness after experiencing a digital nature. Qualitative results stress the importance of variations in nature scenery and highlight the influence of contextual and person-related factors including nature experiences throughout the life span and mobility constraints that older adults may face. Conclusion These findings testify to the potential of using digital nature as a complementary strategy when interactions with outdoor nature become increasingly difficult due to old age.
Diurnal cardio-respiratory changes in ambulatory individuals deciphered using a multi-parameter wearable device
Authors: Nachman Dean , Eisenkraft Arik , Kolben Yotam , Carmon Erez , Hazan Esther , Goldstein Nir , Ben Ishay Arik , Hershkovitz Mor , Fons Meir , Merin Roei , Amir Offer , Asleh Rabea , Gepner Yftach 
Published: December 2023

Background Recent technological developments enable big data-driven insights on diurnal changes. This study aimed to describe the trajectory of multiple and advanced parameters using a medical-grade wearable remote patient monitor. Methods Parameters were monitored for 24 h in 256 ambulatory participants who kept living their normal life. Parameters included heart rate, blood pressure, stroke volume, cardiac index, systemic vascular resistance, blood oxygen saturation, and respiratory rate. Diurnal variations were evaluated, and analyses were stratified based on sex, age, and body mass index. Results All parameters showed diurnal changes ( p < 0.001). Females demonstrated higher heart rate and cardiac index with lower systemic vascular resistance. Obese participants had a higher blood pressure, and lower stroke volume and cardiac index. Systemic vascular resistance was higher among the elderly. Diurnal changes corresponded with awake–sleep hours and differed between sex, age, and body mass index groups. Conclusion Wearable monitoring platforms could decipher hemodynamic changes in subgroups of individuals, and might help with efforts to provide personalized medicine, pre-symptomatic diagnosis and prevention, and drug development.
Transcranial Motor Evoked Potentials as a Predictive Modality for Postoperative Deficit in Cervical Spine Decompression Surgery – A Systematic Review and Meta-Analysis
Authors: Reddy Rajiv P. , Singh-Varma Anya , Chang Robert , Vedire Abhinav , Anetakis Katherine M. , Balzer Jeffrey R. , Crammond Donald J. , Shandal Varun , Lee Joon Y. , Shaw Jeremy D. , Thirumala Parthasarathy D. 
Published: December 2023

Study Design Systematic Review and Meta-analysis. Objective The purpose of this study was to evaluate whether transcranial motor evoked potential (TcMEP) alarms can predict postoperative neurologic complications in patients undergoing cervical spine decompression surgery. Methods A meta-analysis of the literature was performed using PubMed, Web of Science, and Embase to retrieve published reports on intraoperative TcMEP monitoring for patients undergoing cervical spine decompression surgery. The sensitivity, specificity, and diagnostic odds ratio (DOR), of overall, reversible, and irreversible TcMEP changes for predicting postoperative neurological deficit were calculated. A subgroup analysis was performed to compare anterior vs posterior approaches. Results Nineteen studies consisting of 4608 patients were analyzed. The overall incidence of postoperative neurological deficits was 2.58% (119/4608). Overall TcMEP changes had a sensitivity of 56%, specificity of 94%, and DOR of 19.26 for predicting deficit. Reversible and irreversible changes had sensitivities of 16% and 49%, specificities of 95% and 98%, and DORs of 3.54 and 71.74, respectively. In anterior procedures, TcMEP changes had a DOR of 17.57, sensitivity of 49%, and specificity of 94%. In posterior procedures, TcMEP changes had a DOR of 21.01, sensitivity of 55%, and specificity of 94%. Conclusion TcMEP monitoring has high specificity but low sensitivity for predicting postoperative neurological deficit in cervical spine decompression surgery. Patients with new postoperative neurological deficits were 19 times more likely to have experienced intraoperative TcMEP changes than those without new deficits, with irreversible TcMEP changes indicating a much higher risk of deficit than reversible TcMEP changes.
Examining the impact of neighborhood environment factors on residents’ emotions during COVID-19 lockdown and reopening: A Wuhan study on mediation and moderation
Authors: Liu Minghao , Gou Zhonghua 
Published: December 2023

Due to COVID-19, the urban lockdown has caused a significant impact on the mental health of residents. However, limited research investigates the role of neighborhood factors on residents’ mental health during and after the lockdown. This study examines Wuhan, the first city to experience the COVID-19 outbreak, employing multiple linear regression and XGBoost algorithms to analyze the emotional status and distribution of Wuhan residents. The goal of this study is to identify the moderating effect of the neighborhood environment scale on emotional positivity and the marginal effect of the neighborhood environment on residents’ emotions. The results of the study indicate that specific neighborhood environmental characteristics have varying effects on residents’ positive emotions, both before and after the COVID-19 lockdown. The green space ratio, attraction density, waterfront space density, and service facility density all positively affected mood within different distance ranges. Shopping facilities, on the other hand, had mainly positive effects during the open period, with negative effects during the closed period. Furthermore, this study determined scale thresholds where neighborhood environments had a positive effect on mood. For instance, attractions and waterfront areas improved the mood of residents in residential areas, up to at least 3 km away. Medical facilities had a positive effect on residents’ mood beyond 2.2 km. This study highlights crucial implications for planning and managing neighborhoods to promote resilience during future public health crises.
Multiple Ankle Injuries Are Associated With an Increased Risk of Subsequent Concussion in National Football League Players
Authors: Bergstein Victoria E. , Shu Henry T. , Bodendorfer Blake M. , DeFroda Steven , Aiyer Amiethab A. 
Published: December 2023

Background: There is a gap in the literature regarding musculoskeletal risk factors for concussion within the National Football League (NFL), which is an avenue that must be explored to promote player safety given the high incidence of both injury types. This study aims to observe if ankle injuries are associated with an increased risk of subsequent concussion in NFL players. Methods: The public online database ProFootballReference.com was used to identify ankle injuries and concussions in NFL players from the 2009-2010 to 2019-2020 seasons. Multivariable logistic regression for subsequent concussion and ankle injury was performed, adjusting for body mass index (BMI), age, and player position. For descriptive statistics, unpaired t tests with unequal variance were performed for continuous variables, including BMI and age. χ2 testing was performed for categorical variables, including player position, and whether the position was offensive, defensive, or on special teams. Results: Of the 5538 NFL players included in the study, 941 had an ankle injury, 633 had a concussion, and 240 had both an ankle injury and a subsequent concussion. The adjusted odds ratio (aOR) for concussion following a single ankle injury was 0.90 (95% CI 0.72-1.14, P = .387); however, the aOR for concussion following multiple ankle injuries was 2.87 (95% CI 1.23-6.75, P = .015). Special teams players had the lowest risk for concussion (aOR 0.17, 95% CI 0.069-0.36, P < .001) following ankle injury, and there was no significant difference in risk between offense and defense (aOR 0.91, 95% CI 0.77-1.08, P = .295). Conclusion: Multiple ankle injuries were associated with an increased risk of a subsequent concussion after adjusting for BMI; player position; and offense, defense, or special teams designation. These findings can inform injury prevention practices in the National Football League. Level of Evidence: Level III, retrospective comparative study.
Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma
Authors: D’Agostino Mattia , Bertuglia Giuseppe , Rota-Scalabrini Delia , Belotti Angelo , Morè Sonia , Corradini Paolo , Oliva Stefania , Ledda Antonio , Grasso Mariella , Pavone Vincenzo , Ronconi Sonia , Vincelli Iolanda Donatella , Ballanti Stelvio , Velluti Cristina , Cellini Claudia , Gozzetti Alessandro , Palmas Angelo D. , Gamberi Barbara , Mancuso Katia , Paris Laura , Zambello Renato , Petrucci Maria Teresa , Bruno Benedetto , Musto Pellegrino , Gay Francesca 
Published: December 2023

Abstract
The prognostic impact of achieving and in particular maintaining measurable residual disease (MRD) negativity in multiple myeloma is now established; therefore, identifying among MRD-negative patients the ones at higher risk of losing MRD negativity is of importance. We analyzed predictors of unsustained MRD negativity in patients enrolled in the FORTE trial (NCT02203643). MRD was performed by multiparameter flow cytometry (sensitivity of 10−5) at premaintenance and every 6 months thereafter. The cumulative incidence (CI) of MRD resurgence and/or progression was analyzed in MRD-negative patients. A total of 306 of 474 (65%) MRD-negative patients were analyzed. After a median follow-up of 50.4 months from MRD negativity, 185 of 306 (60%) patients were still MRD negative and progression free, 118 (39%) lost their MRD-negative status, and 3 patients (1%) died without progression. Amp1q vs normal (4-year CI, 63% vs 34), ≥2 concomitant high-risk cytogenetic abnormalities vs 0 (4-year CI, 59% vs 33%), circulating tumor cells at baseline (high vs low at 4-year CI, 62% vs 32%), and time-to-reach MRD negativity postconsolidation vs preconsolidation (4-year CI, 46% vs 35%) were associated with a higher risk of unsustained MRD negativity in a multivariate Fine-Gray model. During the first 2 years of maintenance, patients receiving carfilzomib-lenalidomide vs lenalidomide alone had a lower risk of unsustained MRD negativity (4-year CI, 20% vs 33%).
Determining treatment tolerance and fitness for intensive chemotherapy in older adults with AML: a call to action
Authors: Bhatt Vijaya Raj , Uy Geoffrey L. , Klepin Heidi D. 
Published: December 2023

Abstract
Determining fitness for intensive chemotherapy in an older adult with acute myeloid leukemia (AML) is an unanswered age-old question. Geriatric assessment captures any variation in multidimensional health, which can influence treatment tolerance. A prospective study is necessary to validate fitness criteria, determine whether geriatric assessment–based fitness performs superiorly to other criteria, and what components of geriatric assessment are associated with treatment tolerance. A validation study should enroll diverse patients from both academic and community centers and patients receiving intensive and lower-intensity chemotherapy. Geriatric assessment should include at minimum measures of comorbidity burden, cognition, physical function, and emotional health, which in previous smaller studies have shown to be associated with mortality in AML. These assessments should be completed before or within a few days of initiation of chemotherapy to reduce the influence of chemotherapy on the assessment results. Treatment tolerance has been measured by rates of toxicities in patients with solid malignancies; however, during the initial treatment of AML, rates of toxicities are very high regardless of treatment intensity. Early mortality, frequently used in previous studies, can provide a highly consequential and easily identifiable measure of treatment tolerance. The key end point to assess treatment tolerance, thus, should include early mortality. Other end points may include decline in function and quality of life and treatment modifications or cessation due to toxicities. Validating fitness criteria can guide treatment selection and supportive care interventions and are crucial to guide fitness-based trial eligibility, inform the interpretation of trial results, and facilitate drug labeling.
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
Authors: Wang Runfeng , Wang Jin , Zhang Zhiguo , Ma Bo , Sun Shukai , Gao Li , Gao Guodong 
Published: December 2023

Abstract
Background
Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after intracranial hemorrhage (ICH) and investigated possible underlying molecular mechanisms.

Methods
Blood samples of ICH patients were collected to determine the relationship between the serum level of FGF21 and the $$\Delta$$
Δ
GCS%. Wild-type mice, SIRT6flox/flox mice, endothelial-specific SIRT6-homozygous-knockout mice (eSIRT6−/− mice) and cultured human brain microvascular endothelial cells (HCMECs) were used to determine the protective effects of FGF21 on the BBB.

Results
We obtained original clinical evidence from patient data identifying a positive correlation between the serum level of FGF21 and $$\Delta$$
Δ
GCS%. In mice, we found that FGF21 treatment is capable of alleviating BBB damage, mitigating brain edema, reducing lesion volume and improving neurofunction after ICH. In vitro, after oxyhemoglobin injury, we further explored the protective effects of FGF21 on endothelial cells (ECs), which are a significant component of the BBB. Mitochondria play crucial roles during various types of stress reactions. FGF21 significantly improved mitochondrial biology and function in ECs, as evidenced by alleviated mitochondrial morphology damage, reduced ROS accumulation, and restored ATP production. Moreover, we found that the crucial regulatory mitochondrial factor deacylase sirtuin 6 (SIRT6) played an irreplaceable role in the effects of FGF21. Using endothelial-specific SIRT6-knockout mice, we found that SIRT6 deficiency largely diminished these neuroprotective effects of FGF21. Then, we revealed that FGF21 might promote the expression of SIRT6 via the AMPK–Foxo3a pathway.

Conclusions
We provide the first evidence that FGF21 is capable of protecting the BBB after ICH by improving SIRT6-mediated mitochondrial homeostasis.
Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
Authors: Mohamed Riyaz , Sullivan Jennifer C. 
Published: December 2023

Abstract
Background
Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, and mortality rates remain high. There are well established sex differences in renal IR, with males exhibiting greater injury following an ischemic insult compared to females. We recently reported that males have impaired renal recovery from ischemic injury vs. females. However, the mechanisms mediating sex differences in renal recovery from IR injury remain poorly understood. Elevated 12/15 lipoxygenase (LOX) activity has been reported to contribute to the progression of numerous kidney diseases. The goal of the current study was to test the hypothesis that enhanced activation of 12/15 LOX contributes to impaired recovery post-IR in males vs. females.

Methods
13-week-old male and female spontaneously hypertensive rats (SHR) were randomized to sham or 30-minute warm bilateral IR surgery. Additional male and female SHR were randomized to treatment with vehicle or the specific 12/15 LOX inhibitor ML355 1 h prior to sham/IR surgery, and every other day following up to 7-days post-IR. Blood was collected from all rats 1-and 7-days post-IR. Kidneys were harvested 7-days post-IR and processed for biochemical, histological, and Western blot analysis. 12/15 LOX metabolites 12 and 15 HETE were measured in kidney samples by liquid chromatography–mass spectrometry (LC/MS).

Results
Male SHR exhibited delayed recovery of renal function post-IR vs. male sham and female IR rats. Delayed recovery in males was associated with activation of renal 12/15 LOX, increased renal 12-HETE, enhanced endoplasmic reticulum (ER) stress, lipid peroxidation, renal cell death and inflammation compared to females 7-days post-IR. Treatment of male SHR with ML355 lowered levels of 12-HETE and resulted in reduced renal lipid peroxidation, ER stress, tubular cell death and inflammation 7-days post-IR with enhanced recovery of renal function compared to vehicle-treated IR male rats. ML355 treatment did not alter IR-induced increases in plasma creatinine in females, however, tubular injury and cell death were attenuated in ML355 treated females compared to vehicle-treated rats 7 days post-IR.

Conclusion
Our data demonstrate that sustained activation 12/15 LOX contributes to impaired renal recovery post ischemic injury in male and female SHR, although males are more susceptible on this mechanism than females.
Nonlinear Control of Magnetically Coupled Rodless Cylinder Position Servo System
Authors: Zhang Yeming , Kong Demin , Jin Gonghua , Shi Yan , Cai Maolin , Li Shuping , Lv Baozhan 
Published: December 2023

AbstractMagnetically coupled rodless cylinders are widely used in the coordinate positioning of mechanical arms, electrostatic paintings, and other industrial applications. However, they exhibit strong nonlinear characteristics, which lead to low servo control accuracy. In this study, a mass-flow equation through the valve port was derived to improve the control performance, considering the characteristics of the dynamics and throttle-hole flow. Subsequently, a friction model combining static, viscous, and Coulomb friction with a zero-velocity interval was proposed. In addition, energy and dynamic models were set for the experimental investigation of the magnetically coupled rodless cylinder. A nonlinear mathematical model for the position of the magnetically coupled rodless cylinder was proposed. An incremental PID controller was designed for the magnetically coupled rodless cylinder to control this system, and the PID parameters were adjusted online using RBF neural network. The response results of the PID parameters based on the RBF neural network were compared with those of the traditional incremental PID control, which proved the superiority of the optimization control algorithm of the incremental PID parameters based on the RBF neural network servo control system. The experimental results of this model were compared with the simulation results. The average error between the established model and the actual system was 0.005175054 (m), which was approximately 2.588% of the total travel length, demonstrating the accuracy of the theoretical model.
Zn‐doped MnOx nanowires displaying plentiful crystalline defects and tunable small cross-sections for an optimized volcano-type performance towards supercapacitors
Authors: Ribeiro Geyse A. C. , de Lima Scarllett L. S. , Santos Karolinne E. R. , Mendonça Jhonatam P. , Macena Pedro , Pessanha Emanuel C. , Cordeiro Thallis C. , Gardener Jules , Solórzano Guilhermo , Fonsaca Jéssica E. S. , Domingues Sergio H. , dos Santos Clenilton C. , Dourado André H. B. , Tanaka Auro A. , da Silva Anderson G. M. , Garcia Marco A. S. 
Published: December 2023

AbstractMnOx-based nanomaterials are promising large-scale electrochemical energy storage devices due to their high specific capacity, low toxicity, and low cost. However, their slow diffusion kinetics is still challenging, restricting practical applications. Here, a one-pot and straightforward method was reported to produce Zn-doped MnOx nanowires with abundant defects and tunable small cross-sections, exhibiting an outstanding specific capacitance. More specifically, based on a facile hydrothermal strategy, zinc sites could be uniformly dispersed in the α-MnOx nanowires structure as a function of composition (0.3, 2.1, 4.3, and 7.6 wt.% Zn). Such a process avoided the formation of different crystalline phases during the synthesis. The reproducible method afforded uniform nanowires, in which the size of cross-sections decreased with the increase of Zn composition. Surprisingly, we found a volcano-type relationship between the storage performance and the Zn loading. In this case, we demonstrated that the highest performance material could be achieved by incorporating 2.1 wt.% Zn, exhibiting a remarkable specific capacitance of 1082.2 F.g−1 at a charge/discharge current density of 1.0 A g−1 in a 2.0 mol L−1 KOH electrolyte. The optimized material also afforded improved results for hybrid supercapacitors. Thus, the results presented herein shed new insights into preparing defective and controlled nanomaterials by a simple one-step method for energy storage applications.
High-capacity sample multiplexing for single cell chromatin accessibility profiling
Authors: Booth Gregory T. , Daza Riza M. , Srivatsan Sanjay R. , McFaline-Figueroa José L. , Gladden Rula Green , Mullen Andrew C. , Furlan Scott N. , Shendure Jay , Trapnell Cole 
Published: December 2023

AbstractSingle-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but profiling cells from many independent specimens is challenging and costly. Here we describe a novel approach, sciPlex-ATAC-seq, which uses unmodified DNA oligos as sample-specific nuclear labels, enabling the concurrent profiling of chromatin accessibility within single nuclei from virtually unlimited specimens or experimental conditions. We first demonstrate our method with a chemical epigenomics screen, in which we identify drug-altered distal regulatory sites predictive of compound- and dose-dependent effects on transcription. We then analyze cell type-specific chromatin changes in PBMCs from multiple donors responding to synthetic and allogeneic immune stimulation. We quantify stimulation-altered immune cell compositions and isolate the unique effects of allogeneic stimulation on chromatin accessibility specific to T-lymphocytes. Finally, we observe that impaired global chromatin decondensation often coincides with chemical inhibition of allogeneic T-cell activation.