bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between nutrition knowledge and nutritional adequacy in Japanese university students: a cross-sectional study
Authors: Yanagihara Yatsuki , Narumi-Hyakutake Aiko 
Published: February 2025

Abstract
The aim of this study was to examine the relationship between nutrition knowledge and nutritional adequacy among Japanese university students. This cross-sectional study was conducted in 2018 at a university located in Hyogo Prefecture, Kobe, Japan, and 801 students from various academic disciplines were enrolled. Eligible participants were students aged more than 18 years, encompassing all years of study. Nutrition knowledge data were obtained using a nutrition knowledge questionnaire (NKQ) for Japanese adults. Participants were classified into three nutrition knowledge groups according to their total NKQ scores [mean ± standard deviation; all (64.7 ± 15.4%), low (48.1 ± 13.8%), medium (68.3 ± 2.8%), and high (78.5 ± 4.2%)]. Participants reported their dietary habits in the preceding month using a brief self-administered diet history questionnaire. Differences in nutritional adequacy among groups were determined using logistic regression and covariance analyses, adjusted for potential confounding factors. The adequacy of each nutrient was quantified as the proportion of participants with nutrient intake that fell outside the reference range. Although the intakes of only a few nutrients and foods were associated with nutrition knowledge, the total number of nutrients below the estimated average requirement was lower in the high nutrition knowledge group (3.1 ± 2.7) than in the low nutrition knowledge group (3.6 ± 2.9) (P = 0.046). In conclusion, the nutrition knowledge level of Japanese university students is associated with nutritional adequacy but may partially affect eating habits. Future longitudinal studies must clarify the causal and dose-response relationships between nutrition knowledge and dietary habits.
The poet Ulrich von Hutten (1488–1523) and the French disease: the records and human remains of a probable yaws patient
Authors: Gantenbein Urs Leo 
Published: February 2025

Abstract
Ulrich von Hutten (1488–1523), a renowned sixteenth-century German humanist, documented the symptoms of the epidemic that swept through Europe starting around 1495, commonly known as the French Disease. While it has traditionally been associated with venereal syphilis, Dutch tropical physician Willem F. R. Essed proposed in 1933, largely unnoticed to this day, that this new disease might instead be tropical yaws. This study establishes a clear link between Hutten’s reported symptoms and yaws, especially in its secondary and tertiary stages. The skeleton discovered in 1968 on Ufnau Island in Lake Zurich where Hutten died and was buried, exhibits distinct bone manifestations of ancient treponematosis with a pattern more consistent with yaws than syphilis. Furthermore, the correspondence between Hutten’s main symptoms and the lesions observable on the 1968 skeleton further confirms the identification of these human remains. The historical evidence of yaws significantly contributes to our understanding of this early modern epidemic.
Translating data into policy informing decisions: current and future perspectives from the European Food Safety Authority (EFSA)
Authors: Anastassiadou Maria , Devos Yann , Dujardin Bruno , Eskes Chantra , Kouloura Eirini , López-Gálvez Gloria , Rizzi Valentina , Gilsenan Mary B. 
Published: February 2025

Abstract
The European Food Safety Authority (EFSA) provides independent scientific advice to EU risk managers on a wide range of food safety issues and communicates on existing and emerging risks in the food chain. This advice helps to protect consumers, animals and the environment. Data are essential to EFSA’s scientific assessments. EFSA collects data from various sources including scientific literature, biological and chemical monitoring programmes, as well as food consumption and composition databases. EFSA also assesses data from authorisation dossiers for regulated products submitted by industry. To continue delivering the highest value for society, EFSA keeps abreast of new scientific, technological and societal developments. EFSA also engages in partnerships as an essential means to address the growing complexity in science and society, and to better connect and integrate knowledge, data and expertise across sectors. This paper provides insights into EFSA’s data related activities and future perspectives in the following key areas of EFSA’s 2027 strategy: one substance-one assessment, combined exposure to multiple chemicals, environmental risk assessment, new approach methodologies, antimicrobial resistance and risk-benefit assessment. EFSA’s initiatives to integrate societal insights in its risk communication are also described.
Intermittent theta-burst stimulation with adjunctive D-cycloserine rapidly resolves suicidal ideation and decreases implicit association with death/suicide
Authors: Sohn Myren N. , Cole Jaeden , Bray Signe L. , McGirr Alexander 
Published: February 2025

Abstract

Background
Depressive disorders are the most common diagnosis among individuals who die by suicide, and intermittent theta-burst stimulation (iTBS) is a noninvasive treatment for those with difficult-to-treat depression who are at higher risk for suicide. Previous data suggests that pairing iTBS with D-cycloserine, a partial N-methyl-D-aspartate (NMDA) receptor agonist, improves antidepressant outcomes. However, its impact on suicide risk is not known.

Methods
We examine suicidal ideation and implicit suicide risk after iTBS+D-cycloserine in two clinical trials (open-label trial [n = 12] and randomized placebo-controlled trial [RCT, n = 50]) involving adults with major depressive disorder and the acute effects of D-cycloserine on implicit suicide risk in a crossover trial (n = 18). Implicit suicide risk was assessed using the computerized death/suicide implicit association test (IAT), and depressive symptoms and suicidal ideation were assessed using the clinician-rated Montgomery–Asberg Depression Rating Scale (MADRS).

Results
Open-label iTBS+D-cycloserine was associated with a rapid reduction in suicidal ideation, and iTBS+D-cycloserine was superior to iTBS+placebo in reducing suicidal ideation. Similarly, open-label iTBS+D-cycloserine was associated with decreased implicit suicide risk as measured by the death/suicide IAT, and iTBS+D-cycloserine was associated with greater decreases in death/suicide IAT scores compared to iTBS+placebo. A single acute dose of D-cycloserine in the absence of iTBS had no effect on implicit suicide risk.

Conclusions
Adjunctive D-cycloserine with iTBS is a promising strategy to reduce suicidal ideation and implicit suicide risk in depression.
Effects of phonetic training and cognitive aptitude on the perception and production of non-native speech contrasts
Authors: Correia Susana , Rato Anabela , Ge Yuxin , Fernandes João Dinis , Kachlicka Magdalena , Saito Kazuya , Rebuschat Patrick 
Published: February 2025

Abstract
Research on second language (L2) speech learning suggests that incidental perception training can lead to the establishment of non-native phonological categories. The present study contributes to this line of enquiry by investigating how this training is mediated by individual differences in working memory capacity and domain-general auditory processing abilities. In our study, 130 native British English speakers without prior knowledge of Portuguese were randomly assigned to trained or untrained conditions. All participants completed a visual digit span task and an auditory processing test battery. We observed improvements from pretest to post-test in production only, but since both groups improved, these gains cannot be attributed to the incidental perception training. The analysis of the ID measures further confirms the important role played by auditory processing abilities in L2 speech learning. However, more research is needed to better understand the role of incidental perception training and the mediating role of cognitive aptitudes.
Evaluating the acceptability of a self-directed, self-management intervention for patients and caregivers facing advanced cancer
Authors: Wasserman Sydney , Ould Brahim Lydia , Laizner Andrea Maria , Mehta Anita , Côté José , Henry Melissa , Thibodeau Kimberly , Bitzas Vasiliki Bessy , Lambert Sylvie D. 
Published: February 2025

Abstract

Objectives
Coping-Together is a self-directed, self-management intervention initially developed for patients in early-stages of cancer and their caregivers. This study evaluated its acceptability among patients with advanced cancer and their caregivers.

Methods
Twenty-six participants (patients with advanced cancer n = 15 and their caregivers n = 11) were given the Coping-Together materials (6 booklets and a workbook) for 7 weeks. Participants were interviewed twice during this time to solicit feedback on the intervention’s content, design, and recommended changes. Audio-recorded interviews were transcribed verbatim, and thematic analysis was conducted.

Results
Participants found Coping-Together was mostly relevant. All (n = 26, 100%) participants expressed interest and a desire to improve their self-management skills. Perceived benefits included learning to develop SMARTTER (specific, measurable, attainable, relevant, timely, and done together) self-management plans, normalizing challenges, and enhancing communication within the dyad and with their healthcare team. Most (n = 25, 96%) identified strategies from the booklets that benefited them. Top strategies learned were skills to manage physical health (n = 20, 77%) (e.g., monitoring symptoms), emotional well-being (n = 21, 81%) (e.g., reducing stress by reframing thoughts), as well as social well-being (n = 24, 92%) (e.g., communicating with their healthcare team). Barriers included illness severity and time constraints. The unique advanced cancer needs that are to be integrated include support related to fear of death, uncertainty, palliative care and advanced care planning. Suggested modifications involved enhancing accessibility and including more advanced cancer information (e.g., end-of-life planning, comfort care, resources).

Significance of results
Participants reported several benefits from using Coping-Together, with minimal adaptations needed. Creating SMARTTER self-management plans helped them implement self-management strategies. Specific areas for improvement addressed the need for improved accessibility and more content related to advanced cancer. Findings demonstrate how Coping-Together is acceptable for those living with advanced cancer and their caregivers, offering much of the support needed to enhance day-to-day quality of life.
Study of low-profile near-field electromagnetic energy harvesting
Authors: Yadav Subash Chandra , Agrahari Rajan 
Published: February 2025

Abstract
In order to recover the magnetic energy that leaks from an induction cooktop, this study suggests a straightforward and cost-effective magnetic-field energy harvester (MFEH) circuit. With the aid of the intended circuitry, the acquired magnetic energy is transformed into DC electrical energy. We harvested the magnetic-field energy (MFE) from the induction cooktop at various heights and locations of the energy harvesting coil. With a load resister of 46.6 Ω and a capacitance of 1 mF, the developed MFEH circuit, when positioned 2 cm beneath the cooktop, can capture an average DC power of 1936 mW. Placing the energy-harvesting coil 7.5 cm beneath the induction cooktop lowers the power output to 142 mW. For a range of load resister values, the MFE gathered at various locations along the energy harvesting coils is examined. Batteries can be used to store the gathered energy for later use. Additionally, the suggested device is shown to be capable of wirelessly powering low-power Internet of things devices and charging mobile devices. The suggested device differs from the previously published magnetic harvesting circuits due to the induction cooktop’s superior performance and capacity to gather MFE.
Investigation of the Fresnel Scale From Ionospheric Scintillation Spectra
Authors: Song K. , Meziane K. , Hamza A. M. , Jayachandran P. T. 
Published: February 2025

AbstractTrans‐ionospheric radio signals recorded on the ground exhibit random amplitude and phase fluctuations attributed to irregularities in the ionospheric electron density. Studying the ground‐based measurements of trans‐ionospheric radio signals can contribute to understanding plasma instability mechanisms leading to the development of ionospheric structures. In this regard, radio signals emitted from satellites, making up the Global Positioning System (GPS), and recorded by the Canadian High Arctic Ionospheric Network (CHAIN) GPS receivers, are analyzed to study the physical signatures of both amplitude and phase fluctuations. The current ionospheric scintillation paradigm posits that amplitude fluctuations arise from diffraction caused by Fresnel scale ionospheric structures, while refraction is responsible for signal phase variations. The amplitude power spectrum profile consistently displays a rollover frequency, which is not equal to the Fresnel frequency under the Taylor hypothesis. Phase screen theory is used to investigate this phenomenon further and identify an empirical relation between the rollover and Fresnel frequencies. Notably, we have found that the rollover frequency is consistently smaller than the Fresnel frequency. Furthermore, the Fresnel frequency extracted from two‐component phase spectra tends to be larger than the rollover frequency. Based on our results, we have concluded that the identified Fresnel frequencies are directly linked to the ionospheric irregularities causing scintillation.
Piercing the Martian Veil: A Statistical Study of Interplanetary Magnetic Field Reach Through Ionospheric Pressure Balance
Authors: Shaver S. R. , Andersson L. , Ramstad R. , Waghule Bhagyashree , Brain D. , Lillis R. , Cravens T. , Halekas J. , Xu S. , Hinton P. C. , Malaspina D. , Liemohn M. W. , Ledvina S. , Gruesbeck J. R. , Curry S. 
Published: February 2025

AbstractMars, being a small planet with a tenuous atmosphere, does not have a sharp boundary between regions dominated by solar wind plasma and planetary plasma. Instead, this transition is typically extended, allowing the interplanetary magnetic field (IMF) to penetrate into the Martian ionosphere. However, the depth of this penetration is not well understood. Using 6 years of MAVEN data, we statistically assess locations where a transition exists between the dominance of magnetic versus cold (1 eV), thermal plasma pressure to better understand the reach of the IMF. We identify the presence or absence of pressure transitions from 200 to 800 km altitude for each MAVEN orbit and find a clear transition in 55% of cases. The pressure transition locations are mapped in different coordinate systems that provide insight into the solar and planetary driving conditions that cause a detected transition region. Transitions are more likely to occur under weak‐to‐nominal solar wind conditions, away from strong crustal magnetic fields, near the terminator, on the dusk side of the planet compared to the dawn side, and in the negative solar wind motional electric field hemisphere. We speculate on possible causes for asymmetries that arise in the mapped locations of these pressure transitions and the effect that penetrated IMF may have on driving plasma dynamics in the Martian ionosphere.
Seasonal Wind Stress Direction Influences Source and Properties of Inflow to the Salish Sea and Columbia River Estuary
Authors: Brasseale Elizabeth , MacCready Parker 
Published: February 2025

AbstractEstuaries in the northern California current system (NCCS) experience seasonally reversing wind stress, which is expected to impact the origin and properties of inflowing ocean water. Wind stress has been shown to affect the source of estuarine inflow by driving alongshelf currents. However, the effects of vertical transport by wind‐driven Ekman dynamics and other shelf and slope currents on inflow are yet to be explored. Variations in inflow to two NCCS estuarine systems, the Salish Sea and the Columbia River estuary, were studied using particle tracking in a hydrodynamic model. Particles were released in a grid extending two degrees of latitude north and south of each estuary every two weeks of 2017 and tracked for sixty days. Inflow was identified as particles that crossed the estuary mouths. Wind stress was compared with initial horizontal and vertical positions and physical properties of shelf inflow particles. Inflow to the Salish Sea came from Vancouver Island and Washington slope water upwelled through canyons during upwelling‐favorable wind stress, and from Washington slope water or Columbia River plume water during downwelling‐favorable wind stress. Inflow to the Columbia River estuary came from Washington shelf bottom water during upwelling‐favorable wind stress and Oregon shelf surface water during downwelling‐favorable wind stress. For both estuaries, upwelling‐favorable wind stress direction was significantly correlated with a denser and deeper shelf inflow source north of the estuary mouth. These results may help predict the source and properties of inflow to estuaries in other regions with known wind or shelf current patterns.
Improved Representations of Longwave Surface Emissivity to Reduce Surface and Atmospheric Heating Biases in Earth System Models
Authors: Manzo L. , Zender C. , Tolento J. , Whicker‐Clarke C. A. 
Published: February 2025

AbstractMany Earth system models (ESMs) approximate surface emissivity as a broadband constant. This approximation reduces the computational burden, yet omits the spectral structure of emissivity and atmospheric absorption. Neglecting spectral variation in surface emission introduces biases in longwave (LW) atmospheric fluxes and heating. Biases are strongest over surfaces with strongly varying emissivity and minimal atmospheric opacity. We examine these biases over water, ice, and snow surfaces. We partition spectral emissivity into the 16 spectral bands utilized by a single‐column atmospheric radiative transfer model (RRTMG_LW) commonly used in ESMs. We quantify flux and heating biases introduced by broadband assumptions relative to the spectrally resolved case for standard atmospheric profiles over each surface type. Current assumptions tend to overestimate upwelling surface fluxes; for example, the greybody assumption overestimates flux by 1.6 W/m2 (0.52%) at the bottom of a mid‐latitude winter atmosphere over ice, and by 2.33 (1.0%) at the top of atmosphere. The blackbody assumption tends to artificially cool Earth's surface, stabilizing the lower troposphere. Interestingly, the optimal broadband emissivity can deviate from the Planck‐weighted mean by up to 3% depending on surface type and atmospheric profile. We investigate bias sensitivity to surface temperature, cloud water path, and atmospheric water vapor. Bias is most sensitive to water vapor content, and least sensitive to cloud water path. Lastly, we show that a modified greybody method with updated broadband values can reduce total surface flux bias up to 1.69 , comparable to a five‐band approach and at a fraction of the computational cost.
ELM‐Wet: Inclusion of a Wet‐Landunit With Sub‐Grid Representation of Eco‐Hydrological Patches and Hydrological Forcing Improves Methane Emission Estimations in the E3SM Land Model (ELM)
Authors: Yazbeck Theresia , Bohrer Gil , Scyphers Madeline E. , Missik Justine E. C. , Shchehlov Oleksandr , Ward Eric J. , Merino Sergio L. , Bordelon Robert , Taj Diana , Villa Jorge A. , Wrighton Kelly , Zhu Qing , Riley William J. 
Published: February 2025

AbstractWetlands are the largest emitters of biogenic methane (CH4) and represent the highest source of uncertainty in global CH4 budgets. Here, we aim to improve the realism of wetland representation in the U.S. Department of Energy's Exascale Earth System Model land surface model, ELM, thereby reducing uncertainty of CH4 flux predictions. We develop an updated version, ELM‐Wet, where we activate a separate landunit for wetlands that handles multiple wetland‐specific eco‐hydrological patch functional types. We introduce more realistic hydrological forcing through prescribing site‐level constraints on surface water elevation, which allows resolving different sustained inundation depth for different patches, and if data exists, prescribing inundation depth. We modified the calculation of aerenchyma transport diffusivity based on observed conductance per leaf area for different vegetation types. We use Bayesian Optimization to parameterize CO2 and CH4 fluxes in the developed wet‐landunit. Site‐level simulations of a coastal non‐tidal freshwater wetland in Louisiana were performed with the updated model. Eddy covariance observations of CO2 and CH4 fluxes from 2012 to 2013 were used to train the model and data from 2021 were used for validation. Patch‐specific chamber flux observations and observations of CH4 concentration profiles in the soil porewater from 2021 were used for evaluation of the model performance. Our results show that ELM‐Wet reduces the model's CH4 emission root mean squared error by up to 33% and is able to represent inter‐daily CO2 and CH4 flux variability across the wetland's eco‐hydrological patches, including during periods of extreme dry or wet conditions.
Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron
Authors: Li Yingwei , Chen Zhongshao , Xiao Huimin , Liu Yanling , Zhao Chen , Yang Ning , Yuan Cunzhong , Yan Shi , Li Peng 
Published: February 2025

Abstract
Dysregulated alternative splicing has been closely linked to the initiation and progression of tumors. Nevertheless, the precise molecular mechanisms through which splicing factors regulate endometrial cancer progression are still not fully understood. This study demonstrated elevated expression of the splicing factor SNRPB in endometrial cancer samples. Furthermore, our findings indicate that high SNRPB expression is correlated with poor prognosis in patients with endometrial cancer. Functionally, SNRPB inhibition hindered the proliferative and metastatic capacities of endometrial cancer cells. Mechanistically, we revealed that SNRPB knockdown decreased POLD1 expression and that POLD1 intron 22 was retained after SNRPB silencing in endometrial cancer cells, as determined via RNA sequencing data analysis. The retained intron 22 of POLD1 created a premature termination codon, leading to the absence of amino acids 941–1,107 and the loss of the site of interaction with PCNA, which is essential for POLD1 enzyme activity. In addition, POLD1 depletion decreased the increase in the malignancy of endometrial cancer cells overexpressing SNRPB. Furthermore, miR-654-5p was found to bind directly to the 3′ untranslated region of SNRPB, resulting in SNRPB expression inhibition in endometrial cancer. Antisense oligonucleotide-mediated SNRPB inhibition led to a decrease in the growth capacity of a cell-derived xenograft model and a patient with endometrial cancer-derived xenograft model. Overall, SNRPB promotes the efficient splicing of POLD1 by regulating intron retention, ultimately contributing to high POLD1 expression in endometrial cancer. The oncogenic SNRPB–POLD1 axis is an interesting therapeutic target for endometrial cancer, and antisense oligonucleotide-mediated silencing of SNRPB may constitute a promising therapeutic approach for treating patients with endometrial cancer.