bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal variations and source analysis of VOCs in the environmental air of a typical pesticide remediation site
Authors: Li Xuwei , Ding Da , Xie Wenyi , Li Xuzhi , Wang Mengjie , Kong Lingya , Jiang Dengdeng , Deng Shaopo 
Published: October 2023

As efforts to mitigate soil and groundwater pollution intensify nationwide, the incidence of volatile organic compound (VOC) contaminated sites has risen significantly. These sites exhibit continuous release and dispersion of VOCs during and after remediation/control processes, thereby adversely affecting the local environment and residents. This issue has emerged as a prominent concern in contemporary society. This study takes a representative pesticide-contaminated site as the research subject. The pollutant levels, composition, spatiotemporal distribution, and source characteristics of VOCs in the ambient air environment from 2016 to 2021 were investigated by statistical analysis, Geographic Information System (GIS) spatial interpolation, Positive Matrix Factorization (PMF) model, and characteristic ratio source. The results showed that the average mass concentration proportions of the five types of pollutants are: benzene, toluene, ethylbenzene, and xylenes (BTEX) (29.73%) &gt; alkanes (26.85%) &gt; oxygenated hydrocarbons (21.96%) &gt; halogenated hydrocarbons (19.12%) &gt; sulfides (2.35%). M-/p-xylenes and toluene were the main contributing pollutants of BTEX and appeared frequently in the lists of top three pollutant in the contribution rates at various sites. The average concentration range of VOCs inside (EA1∼EA5) and outside the site (CK1∼CK4) were 810.71–1437.24 μg/m³, and 784.47–1358.16 μg/m³, respectively. The spatial distribution and variation trend in concentrations of halogenated hydrocarbons and alkanes were similar, with both being high in the middle of the site in 2017 and high in the south in 2018, and then sharply falling to a lower level in 2019. The source analysis results showed that the main contribution sources of environmental air varied over time. There were three types of emission sources for VOCs during the monitoring periods in 2016 and 2018. The maximum contributions to total volatile organic compounds (TVOCs) in 2016 and 2018 were volatile sources of characteristic pollutants within the site (45.6%) and volatile source of fuel (70.6%), respectively. This study provides scientific evidence for the environmental management, planning, and VOCs pollution control of pesticide-contaminated sites in China.
Case Report: Fatal cytomegalovirus pneumonia after CAR-T cell therapy in the long-term follow-up
Authors: Cheng Jiali , Huang Jin , Cao Wenyue , Huang Liang , Mao Xia , Chen Liting , Zhou Jianfeng , Wang Na 
Published: October 2023

IntroductionThe rapidly developed CAR-T cell therapy has a unique profile of side effects, which perhaps has not been totally realized and understood, especially the late-phase toxicity. CMV is prevalent world-wide and establishes a life-long latency infection. It can lead to life-threatening complications in immunocompromised host, and little is known about CMV disease in patients after CAR-T cell therapy. Here, we report a patient who developed possible CMV-pneumonia three months after anti-CD19 and anti-CD22 CAR-T cell therapy for relapsed B-ALL, contributing to the understanding of severe side-effects mediated by virus infection or reactivation in patients receiving CAR-T cell infusion.Case presentationA 21-year old male patient with relapsed B-ALL received anti-CD19/22 CAR-T cell therapy, and achieved complete remission 2 weeks after the infusion. However, three months later, the patient was hospitalized again with a 10-day history of fever and cough and a 3-day history of palpitations and chest tightness. He was diagnosed with possible CMV pneumonia. Under treatment with antiviral medicine (ganciclovir/penciclovir), intravenous gamma globulin and methylprednisolone and the use of BiPAP ventilator, his symptoms improved, but after removing penciclovir his symptoms went out of control, and the patient died of respiratory failure 22 days after admission.ConclusionCMV infection/reactivation can occur in patients long after receiving anti-CD19/22 CAR-T cell therapy, and induce fatal pneumonia, which reminds us of the late side effects associated with immunosuppression after CAR-T cell infusion.
Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors
Authors: Kropp Korbinian N. , Fatho Martina , Huduti Enes , Faust Marilena , Lübcke Silke , Lennerz Volker , Paschen Annette , Theobald Matthias , Wölfel Thomas , Wölfel Catherine 
Published: October 2023

IntorductionChondroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight-melanoma associated antigen, is expressed in melanoma but also other tumor entities and constitutes an attractive target for immunotherapeutic approaches. While recent preclinical reports focused on anti-CSPG4 chimeric antigen receptors (CAR), we here explore T-cell receptor (TCR)-based approaches targeting CSPG4.MethodsThe TCRs of two CSPG4-reactive T-cell clones (11C/73 and 2C/165) restricted by the highly prevalent HLA-C*07:01 allele were isolated and the respective αβTCR pairs were retrovirally expressed in CRISPR/Cas9-edited TCR-knockout T cells for functional testing. We also combined alpha and beta TCR chains derived from 11C/73 and 2C/165 in a cross-over fashion to assess for hemichain dominance. CSPG4+ melanoma, glioblastoma and lung cancer cell lines were identified and, if negative, retrovirally transduced with HLA-C*07:01.ResultsFunctional tests confirmed specific recognition of CSPG4+HLA-C*07:01+ target cells by the αβTCR retrieved from the parental T-cell clones and in part also by the cross-over TCR construct 2Cα-11Cβ. Despite high surface expression, the 11Cα-2Cβ combination, however, was not functional.DiscussionCollectively, 11C/73- and 2C/165-expressing T cells specifically and efficiently recognized CSPG4+HLA-C*07:01+ cancer cells which warrants further preclinical and clinical evaluation of these TCRs.
Using contribution analysis to evaluate health professions and health sciences programs
Authors: Choi Tammie , Sarkar Mahbub , Bonham Maxine , Brock Tina , Brooks Ingrid Ann , Diug Basia , Ilic Dragan , Kumar Arunaz , Lau Wee-Ming , Lindley Jennifer , Morphet Julia , Simmons Margaret , Volders Evelyn , White Paul J. , Wright Caroline , Palermo Claire 
Published: October 2023

Introduction/backgroundCourse evaluation in health education is a common practice yet few comprehensive evaluations of health education exist that measure the impact and outcomes these programs have on developing health graduate capabilities.Aim/objectivesTo explore how curricula contribute to health graduate capabilities and what factors contribute to the development of these capabilities.MethodsUsing contribution analysis evaluation, a six-step iterative process, key stakeholders in the six selected courses were engaged in an iterative theory-driven evaluation. The researchers collectively developed a postulated theory-of-change. Then evidence from existing relevant documents were extracted using documentary analysis. Collated findings were presented to academic staff, industry representatives and graduates, where additional data was sought through focus group discussions - one for each discipline. The focus group data were used to validate the theory-of-change. Data analysis was conducted iteratively, refining the theory of change from one course to the next.ResultsThe complexity in teaching and learning, contributed by human, organizational and curriculum factors was highlighted. Advances in knowledge, skills, attitudes and graduate capabilities are non-linear and integrated into curriculum. Work integrated learning significantly contributes to knowledge consolidation and forming professional identities for health professional courses. Workplace culture and educators’ passion impact on the quality of teaching and learning yet are rarely considered as evidence of impact.DiscussionCapturing the episodic and contextual learning moments is important to describe success and for reflection for improvement. Evidence of impact of elements of courses on future graduate capabilities was limited with the focus of evaluation data on satisfaction.ConclusionContribution analysis has been a useful evaluation method to explore the complexity of the factors in learning and teaching that influence graduate capabilities in health-related courses.
Res-FLNet: human-robot interaction and collaboration for multi-modal sensing robot autonomous driving tasks based on learning control algorithm
Authors: Wang Shulei 
Published: October 2023

IntroductionRes-FLNet presents a cutting-edge solution for addressing autonomous driving tasks in the context of multimodal sensing robots while ensuring privacy protection through Federated Learning (FL). The rapid advancement of autonomous vehicles and robotics has escalated the need for efficient and safe navigation algorithms that also support Human-Robot Interaction and Collaboration. However, the integration of data from diverse sensors like cameras, LiDARs, and radars raises concerns about privacy and data security.MethodsIn this paper, we introduce Res-FLNet, which harnesses the power of ResNet-50 and LSTM models to achieve robust and privacy-preserving autonomous driving. The ResNet-50 model effectively extracts features from visual input, while LSTM captures sequential dependencies in the multimodal data, enabling more sophisticated learning control algorithms. To tackle privacy issues, we employ Federated Learning, enabling model training to be conducted locally on individual robots without sharing raw data. By aggregating model updates from different robots, the central server learns from collective knowledge while preserving data privacy. Res-FLNet can also facilitate Human-Robot Interaction and Collaboration as it allows robots to share knowledge while preserving privacy.Results and discussionOur experiments demonstrate the efficacy and privacy preservation of Res-FLNet across four widely-used autonomous driving datasets: KITTI, Waymo Open Dataset, ApolloScape, and BDD100K. Res-FLNet outperforms state-of-the-art methods in terms of accuracy, robustness, and privacy preservation. Moreover, it exhibits promising adaptability and generalization across various autonomous driving scenarios, showcasing its potential for multi-modal sensing robots in complex and dynamic environments.
Prediagnosis ultra-processed food consumption and prognosis of patients with colorectal, lung, prostate, or breast cancer: a large prospective multicenter study
Authors: Pu Jian-Yuan , Xu Wei , Zhu Qian , Sun Wei-Ping , Hu Jie-Jun , Cai Dong , Zhang Jun-Yong , Gong Jian-Ping , Xiong Bin , Zhong Guo-Chao 
Published: October 2023

Background and aimsWhether ultra-processed food consumption is associated with cancer prognosis remains unknown. We aimed to test whether prediagnosis ultra-processed food consumption is positively associated with all-cause and cancer-specific mortality in patients with colorectal, lung, prostate, or breast cancer.MethodsThis study included 1,100 colorectal cancer patients, 1750 lung cancer patients, 4,336 prostate cancer patients, and 2,443 breast cancer patients. Ultra-processed foods were assessed using the NOVA classification before the diagnosis of the first cancer. Multivariable Cox regression was used to calculate hazard ratio (HR) and 95% confidence interval (CI) for all-cause and cancer-specific mortality.ResultsHigh ultra-processed food consumption before cancer diagnosis was significantly associated with an increased risk of all-cause mortality in lung (HRquartile 4 vs. 1: 1.18; 95% CI: 0.98, 1.40; Ptrend = 0.021) and prostate (HRquartile 4 vs. 1: 1.18; 95% CI: 1.00, 1.39; Ptrend = 0.017) cancer patients in a nonlinear dose–response manner (all Pnonlinearity &lt; 0.05), whereas no significant results were found for other associations of interest. Subgroup analyses additionally revealed a significantly positive association with colorectal cancer-specific mortality among colorectal cancer patients in stages I and II but not among those in stages III and IV (Pinteraction = 0.006), and with prostate cancer-specific mortality among prostate cancer patients with body mass index &lt;25 but not among those with body mass index ≥25 (Pinteraction = 0.001).ConclusionOur study suggests that reducing ultra-processed food consumption before cancer diagnosis may improve the overall survival of patients with lung or prostate cancer, and the cancer-specific survival of certain subgroups of patients with colorectal or prostate cancer.
Case Report: A recurrent case of ALK-ALCL after autologous transplantation was successfully treated with BV + a modified CHEP chemotherapy containing mitoxantrone hydrochloride liposome with the addition of chidamide maintenance therapy
Authors: Shang Zhen , Zhang Qi , Liu Wanying , Wu Jiaying , Zhang Yicheng , Xiao Yi 
Published: October 2023

BackgroundALK-negative anaplastic large cell lymphoma (ALK-ALCL) is a rare heterogeneous malignancy of T-cell origin.ALK- ALCL has a poor prognosis, with more patients experiencing relapses and refractory to treatment, and its treatment remains challenging. We report a case with bone involvement as the main clinical manifestation of recurrent, and the patient achieved significant partial remission after brentuximab vedotin(BV) combined with a modified CHEP chemotherapy containing mitoxantrone hydrochloride liposome (PLM60) with the addition of chidamide maintenance therapy and received regular follow-up, with a disease-free survival of 16 months to date. A literature review of the clinical presentation and treatment of ALCL was also conducted to identify strategies for its diagnosis and management.ConclusionsALK-ALCL with bone involvement as the main manifestation of recurrent is relatively rare. Here, BV combined a modified CHEP chemotherapy containing mitoxantrone hydrochloride liposome was applied for the first time in a patient with relapsed ALK-ALCL, inducing remission and extending survival. However, further prospective studies with many patients are needed to determine the biological characteristics of this rare type of ALK-ALCL and relevant treatment strategies.
The osteopath-parent-child triad in osteopathic care in the first 2 years of life: a qualitative study
Authors: Accardi Caterina , Cerritelli Francesco , Bovo Lorenza , Esteves Jorge E. 
Published: October 2023

BackgroundEnactivism and active inference are two important concepts in the field of osteopathy. While enactivism emphasizes the role of the body and the environment in shaping our experiences and understanding of the world, active inference emphasizes the role of action and perception in shaping our experiences and understanding of the world. Together, these frameworks provide a unique perspective on the practice of osteopathy, and how it can be used to facilitate positive change in patients. Since the neonatal period is a crucial time for development, osteopaths should aim to create a therapeutic relationship. Arguably, through participatory sense-making, osteopaths can help the baby build a generative model (with positive priors) to deal with stress and needs throughout their life.AimSince the literature considers that interactions with the environment, which enact the patients’ experiences, depending on contextual factors and communication between patient and caregiver, this research explored whether there is a correspondence between the indications in the literature and clinical practice in the management of the mother/parent–child dyad during osteopathic care on children aged 0 to 2 years old.MethodsSemi-structured interviews were conducted with a purposive sample of nine osteopaths with experience in the field of pediatrics. Interviews were transcribed verbatim, and constructivist grounded theory was used to conceptualize, collect and analyze data. Codes and categories were actively constructed through an interpretive/constructionist paradigm.ResultsThe core category was the idea of the pediatric osteopath as a support for the family, not only for the child. Four additional categories were identified: (1) Preparing a safe environment for both children and parents, (2) Communication, (3) Attachment and synchrony, and (4) Synchronization.ConclusionThrough participatory sense-making, osteopaths manage contextual factors to establish an effective therapeutic alliance through the osteopath-parent–child triad to facilitate the construction of the child’s internal generative model to promote healthy development. The therapeutic encounter is considered an encounter between embodied subjects, occurring within a field of affordances (ecological niche) that allows the interlocutors to actively participate in creating new meanings through interpersonal synchronization. Participatory sense-making and the establishment of a therapeutic alliance through the osteopath-parent–child triad are crucial to promote healthy development in the child.
Exploring chronic pain related attentional experiences, distress and coping strategies among Arabic-speaking individuals in Jordan and the United Kingdom
Authors: Abudoush Ahmad N. , Ali Khalifa , Kiran Tayyeba , Panagioti Maria , Poliakoff Ellen , Mo Hom Nang , Husain Nusrat 
Published: October 2023

IntroductionThe lived experiences of chronic pain (CP) among Arabic-speaking populations remain underexplored. A better understanding of these experiences and their associations with attention difficulties, coping mechanisms, and treatment options could lead to improved support for this group.MethodsThis qualitative study utilised a descriptive design and involved one-to-one interviews with 51 participants with CP who had just completed two attention tasks. Interviews were conducted using a semi-structured topic guide, transcribed verbatim and translated from Arabic to English before agreeing on the coding framework. Themes and subthemes were extracted using a framework analysis approach.ResultsThe study identified six main themes: Factors contributing towards developing or exacerbating CP, the impact of CP on psychosocial functions, including attention, the perceived role of social support, coping strategies for managing CP, perceptions about available treatments and recommendations for interventions.DiscussionCP significantly impacts individuals’ physical and psychosocial functions, and it is reciprocally associated with attentional difficulties. Despite using various approaches to manage their CP, none of the participants used psychological interventions or counselling. Understanding the diverse impacts of CP and the coping strategies employed to develop culturally sensitive interventions, review current related policies, and improve healthcare services is crucial to managing CP among this population.
Sanitation-related violence against women in informal settlements in Kenya: a quantitative analysis
Authors: Winter Samantha C. , Johnson Laura , Dzombo Millicent N. 
Published: October 2023

IntroductionApproximately 3.6 billion people around the world do not have access to safe sanitation options. Those lacking access are not only at risk of diarrheal disease, other tropical diseases, and parasitic infections, they are at greater risk of experiencing violence, particularly women and girls. The burden of lack of access to safe sanitation is disproportionately experienced by women in informal settlements in lower- and middle-income countries, where violence rates tend to be higher and access to sanitation lower. Women lacking access to safe toilets often have to walk long distances to access a facility or open site or use shared toilet facilities, which increase their vulnerability to violence.MethodsWe explore the prevalence and multilevel factors associated with women's experiences, observations, and exposure to stories about past-year sanitation-related violence in a probability sample of 550 women in a large informal settlement in Nairobi, Kenya using chi-square tests and multivariate logistic regressions.ResultsFindings suggest that social/community engagement and social/cultural beliefs are important considerations for hearing about and observing sanitation-related violence, but less so experiences of sanitation-related violence. Alternatively, individual-level and technological factors may be critical factors in actual experiences of violence.DiscussionSanitation-related violence and creating an environment of safety in which women can take care of their sanitation-related needs in ways that also protect them, their families, and their communities is critical for meeting sanitation-related development agendas and goals such as Sustainable Development Goal 6.2 to achieve access to adequate and equitable sanitation and hygiene for all by 2030.
Evaluation of the validated intraoperative bleeding scale in liver surgery: study protocol for a multicenter prospective study
Authors: Aparicio-López Daniel , Asencio-Pascual José Manuel , Blanco-Fernández Gerardo , Cugat-Andorrá Esteban , Gómez-Bravo Miguel Ángel , López-Ben Santiago , Martín-Pérez Elena , Sabater Luis , Ramia José Manuel , Serradilla-Martín Mario 
Published: October 2023

BackgroundSurgical hemostasis has become one of the key principles in the advancement of surgery. Hemostatic agents are commonly administered in many surgical specialties, although the lack of consensus on the definition of intraoperative bleeding or of a standardized system for its classification means that often the most suitable agent is not selected. The recommendations of international organizations highlight the need for a bleeding severity scale, validated in clinical studies, that would allow the selection of the best hemostatic agent in each case. The primary objective of this study is to evaluate the VIBe scale (Validated Intraoperative Bleeding Scale) in humans. Secondary objectives are to evaluate the scale's usefulness in liver surgery; to determine the relationship between the extent of bleeding and the hemostatic agent used; and to assess the relationship between the grade of bleeding and postoperative complications.MethodsProspective multicenter observational study including 259 liver resections that meet the inclusion criteria: patients scheduled for liver surgery at one of 10 medium-high volume Spanish HPB centers using an open or minimally invasive approach (robotic/laparoscopic/hybrid), regardless of diagnosis, ASA score &lt;4, age ≥18, and who provide signed informed consent during the study period (September 2023 until the required sample size has been recruited). The participating researchers will be responsible for collecting the data and for reporting them to the study coordinators.DiscussionThis study will allow us to evaluate the VIBe scale for intraoperative bleeding in humans, with a view to its subsequent incorporation in daily clinical practice.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT05369988?term = serradilla&amp;draw = 2&amp;rank = 3, [NCT0536998].