bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive association between omega-3/6 polyunsaturated fatty acids and idiopathic normal pressure hydrocephalus: a mendelian randomization study
Authors: Li Jilai , Huang Ning , Zhang Xiang , Peng Jie , Huang Qin 
Published: December 2023

Background: Idiopathic normal pressure hydrocephalus (iNPH) is a common disease among the elderly, which brings great harm to the health of patients and imposes a huge economic burden on the healthcare system. Research has shown that it is possible to prevent iNPH through nutritional and dietary interventions. Intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) can reduce the risk of many diseases. In this study, we aimed to explore the association between omega-3/6 PUFAs and iNPH.Methods: We conducted a two-sample Mendelian randomization (MR) study using summary data from publicly available genome-wide association studies (GWAS) to evaluate the potential impact of omega-3 and omega-6 PUFAs on the risk of iNPH in European populations. Inverse variance weighting was used as the main method for MR analysis, with Wald ratio, weighted median, MR-Egger, simple mode, and weighted mode as supplementary methods. In addition, we performed a series of instrument variable strength evaluations and sensitivity analyses to test the reliability of the study results. Finally, we also conducted a linkage disequilibrium score regression (LDSC) analysis to assess the genetic correlation and distinguish between causal associations and shared genetic variants between PUFAs and iNPH.Results: One SD increase in genetically predicted levels of total omega-3 PUFAs (OR: 0.748; 95% CI: 0.597–0.937; p = 0.012; IVW), DHA (OR: 0.709; 95% CI: 0.532–0.945; p = 0.019; IVW), ALA (OR: 0.001; 95% CI: 1.17E-06–0.423; p = 0.026; Wald ratio), and DHA (OR: 0.709; 95% CI: 0.532–0.945; p = 0.019; IVW) were associated with a reduced iNPH risk. LDSC did not reveal any significant genetic correlations.Conclusion: Higher genetically predicted levels of total omega-3 PUFAs, ALA, DHA, and DPA are associated with a reduced risk of iNPH. These findings have important implications for preventing iNPH and future nutritional guidance.
Implications of tRNA abundance on translation elongation across bovine tissues
Authors: Goldkamp Anna K. , Hagen Darren E. 
Published: December 2023

Introduction: Translation is a crucial stage of gene expression. It may also act as an additional layer of regulation that plays an important role in gene expression and function. Highly expressed genes are believed to be codon-biased to support increased protein production, in which quickly translated codons correspond to highly abundant tRNAs. Synonymous SNPs, considered to be silent due to the degeneracy of the genetic code, may shift protein abundance and function through alterations in translational efficiency and suboptimal pairing to lowly abundant tRNAs.Methods: Here, we applied Quantitative Mature tRNA sequencing (QuantM-tRNAseq) and ribosome profiling across bovine tissues in order to investigate the relationship between tRNA expression and slowed translation.Results: Moreover, we have identified genes modulated at transcriptional and/or translational levels underlying tissue-specific biological processes. We have also successfully defined pausing sites that depict the regulatory information encoded within the open reading frame of transcripts, which could be related to translation rate and facilitate proper protein folding. This work offers an atlas of distinctive pausing sites across three bovine tissues, which provides an opportunity to predict codon optimality and understand tissue-specific mechanisms of regulating protein synthesis.
Growth and natural mortality of Maurolicus muelleri and Benthosema glaciale in the Northeast Atlantic Ocean
Authors: Vastenhoud Berthe M. J. , Mildenberger Tobias K. , Kokkalis Alexandros , Paoletti Silvia , Alvarez Paula , Garcia Dorleta , Wieczorek Alina M. , Klevjer Thor , Melle Webjørn , Jonsson Sigurður T. , Nielsen J. Rasmus 
Published: December 2023

Mesopelagic fish are considered a possible future fisheries resource, but the biological sustainability of their potential exploitation has not yet been assessed. Sustainability should be evaluated at the population level, for which accurate stock-specific life-history parameters are required. Here, we use a length-based model to estimate life-history parameters related to growth and natural mortality, and their uncertainty, for the assessment of Northeast Atlantic populations of Maurolicus muelleri (Gmelin, 1789, Mueller’s Pearlside) and Benthosema glaciale (Reinhardt, 1837, glacier lantern fish). We compare three different approaches to estimate natural mortality rates and provide recommendations for future data collection and monitoring programs. For M. muelleri, we estimated an asymptotic length of 57.98 mm and a von Bertalanffy growth constant of 1.28 year−1, while for B. glaciale, we estimated an asymptotic length of 78.93 mm and a von Bertalanffy growth constant of 0.41 year−1. Estimates of natural mortality rates for M. muelleri were around 1.29 year−1 and 1.80 year−1 based on empirical formulae with the estimated growth parameters and maximum age, respectively, and around 1.51 year−1 with the length-converted catch curve method for B. glaciale estimates ranged between 0.5, 0.68, and 0.75 year−1, with the three respective methods. Due to limited data availability, the estimated uncertainty of the provided life-history parameters is large and should be considered in the evaluation of the sustainability of potential mesopelagic exploitation following the precautionary approach.
Day one postoperative MRI findings following electrode placement for deep brain stimulation: analysis of a large case series
Authors: Succop Benjamin S. , Zamora Carlos , Roque Daniel Alberto , Hadar Eldad , Kessler Brice , Quinsey Carolyn 
Published: December 2023

ObjectiveThis study sought to characterize postoperative day one MRI findings in deep brain stimulation (DBS) patients.MethodsDBS patients were identified by CPT and had their reviewed by a trained neuroradiologist and neurosurgeon blinded to MR sequence and patient information. The radiographic abnormalities of interest were track microhemorrhage, pneumocephalus, hematomas, and edema, and the occurrence of these findings in compare the detection of these complications between T1/T2 gradient-echo (GRE) and T1/T2 fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) sequences was compared. The presence, size, and association of susceptibility artifact with other radiographic abnormalities was also described. Lastly, the association of multiple microelectrode cannula passes with each radiographic finding was evaluated. Ad-hoc investigation evaluated hemisphere-specific associations. Multiple logistic regression with Bonferroni correction (corrected p = 0.006) was used for all analysis.ResultsOut of 198 DBS patients reviewed, 115 (58%) patients showed entry microhemorrhage; 77 (39%) track microhemorrhage; 44 (22%) edema; 69 (35%) pneumocephalus; and 12 (6%) intracranial hematoma. T2 GRE was better for detecting microhemorrhage (OR = 14.82, p &lt; 0.0001 for entry site and OR = 4.03, p &lt; 0.0001 for track) and pneumocephalus (OR = 11.86, p &lt; 0.0001), while T2 FLAIR was better at detecting edema (OR = 123.6, p &lt; 0.0001). The relatively common findings of microhemorrhage and edema were best visualized by T2 GRE and T2 FLAIR sequences, respectively. More passes intraoperatively was associated with detection of ipsilateral track microhemorrhage (OR = 7.151, p &lt; 0.0001 left; OR = 8.953, p &lt; 0.0001 right). Susceptibility artifact surrounding electrodes possibly interfered with further detection of ipsilateral edema (OR = 4.323, p = 0.0025 left hemisphere only).DiscussionDay one postoperative magnetic resonance imaging (MRI) for DBS patients can be used to detect numerous radiographic abnormalities not identifiable on a computed tomographic (CT) scan. For this cohort, multiple stimulating cannula passes intraoperatively was associated with increased microhemorrhage along the electrode track. Further studies should be performed to evaluate the clinical relevance of these observations.
Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain
Authors: Regnath Franziska , Biersack Katharina , Jäger Nina , Glasauer Stefan , Lehnen Nadine 
Published: December 2023

IntroductionFunctional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain.MethodA total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants' eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control.ResultsUsing a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment.ConclusionOur results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits. We discuss outcome parameter choice, organ system specificity, and selection of patient diagnoses as possible reasons for this result and recommend future avenues for research.
Clinical efficacy and safety of robotic retroperitoneal lymph node dissection for testicular cancer: a systematic review and meta-analysis
Authors: Yuan Yacheng , Zhang Dawei , Ning Yiping , Luo Hengfeng , Qiu Xiaolong , Tan Yangyang , Li Yuxiang , Yang Xukai 
Published: December 2023

BackgroundRetroperitoneal lymph node dissection (RPLND) is an effective treatment for testicular tumors. In recent years, with the development of robotics, many urological procedures performed via standard laparoscopy have been replaced by robots. Our objective was to compare the safety and efficacy of robotic retroperitoneal lymph node dissection (R-RPLND) versus Non-robotic retroperitoneal lymph node dissection (NR-RPLND) in testicular cancer.MethodsPubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for literature on robotic surgery for testicular germ cell tumors up to April 2023. The statistical and sensitivity analyses were performed using Review Manager 5.3. Meta-analysis was performed to calculate mean difference (MD), odds ratio(OR), and 95% confidence interval (CI) effect indicators.ResultsEight studies with 3875 patients were finally included in this study, 453 with R-RPLND and 3422 with open retroperitoneal lymph node dissection (O-RPLND)/laparoscopic retroperitoneal lymph node dissection (L-RPLND). The results showed that R-RPLND had lower rates of intraoperative blood loss (MD = -436.39; 95% CI -707.60 to -165.19; P = 0.002), transfusion (OR = 0.06; 95% CI 0.01 to 0.26; P = 0.0001), total postoperative complication rates (OR = 0.39; 95% CI 0.21 to 0.70; P = 0.002), and length of stay (MD=-3.74; 95% CI -4.69 to -2.78; P&lt;0.00001). In addition, there were no statistical differences between the two groups regarding perioperative and oncological outcomes regarding total operative time, the incidence of postoperative complications grade≥III, abnormal ejaculation rate, lymph node yield, and postoperative recurrence rate.ConclusionsThe R-RPLND and O-RPLND/L-RPLND provide safe and effective retroperitoneal lymph node dissection for testicular cancer. Patients with R-RPLND have less intraoperative bleeding, shorter hospitalization period, fewer postoperative complications, and faster recovery. It should be considered a viable alternative to O-RPLND/L-RPLND.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023411696.
Cost-effectiveness analysis of elacestrant versus standard endocrine therapy for second-/third-line treatment of patients with HR+/HER2- advanced or metastatic breast cancer: a US payer perspective
Authors: Zeng Wanxian , Cao Xueqiong , Lin Jingwen , Zheng Bin , Li Na , Liu Maobai , Cai Hongfu 
Published: December 2023

BackgroundThis study evaluated the cost-effectiveness of elacestrant (ELA) and standard-of-care (SOC) as second-/third-line treatment for pretreated estrogen receptor (ER)– positive/human epidermal growth factor receptor 2 (HER2)–negative advanced or metastatic breast cancer (A/MBC) in the US.MethodsThe 3 health states partitioned survival model (PSM) was conducted from the perspective of the US third-party payers. The time horizon for the model lasted 10 years. Effectiveness and safety data were derived from the EMERALD trial (NCT03778931). Costs were derived from the pricing files of Medicare and Medicaid Services, and utility values were derived from published studies. One-way sensitivity analysis as well as probabilistic sensitivity analysis were performed to observe model stability.ResultELA led to an incremental cost-effectiveness ratio (ICER) of $8,672,360/quality-adjusted life year (QALY) gained compared with SOC in the overall population and $2,900,560/QALY gained compared with fulvestrant (FUL) in the ESR1(estrogen receptor 1) mutation subgroup. The two ICERs of ELA were significantly higher than the willingness-to-pay (WTP) threshold values of $150,000/QALY.ConclusionsELA was not cost-effective for the second-/third-line treatment of patients with ER+/HER2–A/MBC compared with SOC in the US.
Exploring the restorative benefits of work in smart working structures on vacations in small villages
Authors: Maffei Luigi , Ciervo Antonio , Marzocchi Raffaella , Masullo Massimiliano 
Published: December 2023

IntroductionProcesses of redefinition of work, already in place in the pre-pandemic era, with the advent of COVID-19, have become widely required. A “model of work” that uses new technologies and the development of existing ones to improve workers’ performance and satisfaction has emerged. Smart working has changed how people work and, as a result, spaces must also change to support them. The use of prefabricated movable buildings (PMB) could represent an opportunity to create smart (and co-) working spaces in a regenerative contest. Small villages with historical, architectural, and naturalistic elements and slow-life features are potential platforms where vacation and work could merge easily. This paper aims to establish if working in movable offices, like the PMBs, which provide a high level of visual and acoustics interaction with the surroundings, and which is positioned in small villages’ squares, can affect workers’ sense of restoration and working performance.MethodsIn a laboratory setting, in the SENS i-Lab, a videowall and a 3D spatial audio system were used to compare, in terms of restorativeness and self-reported cognitive performance, the effects of a high-rise building context of a City Business District (CBD), i.e. the control scenario, and of two typical squares of small Italian villages with historic buildings, without (HIS) and with water elements (HIS-W).ResultsThe findings of the experimental sessions showed that when working in close contact (visual and auditory) with historical or water elements, where life flows slowly, workers perceived a higher sense of restoration while job performance was unchanged.DiscussionImplementing smart working policies in small villages that encourage the use of energy-efficient prefabricated movable buildings and that offer a high level of visual and acoustic interaction with the surrounding environment may represent a promising strategy to foster the development of the local economy and contrast the depopulation of small villages, improving the worker well-being and the reducing the impact of their activities of the environment.
Teaching higher education staff to understand and support autistic students: evaluation of a novel training program
Authors: Jenks Emma , Selman Freya , Harmens Miriam , Boon Sarah , Tran Trang , Hobson Hannah , Eagle Sarah , Sedgewick Felicity 
Published: December 2023

BackgroundAutistic students are particularly vulnerable to stressors within a university environment and are more likely to experience poor mental health than their non-autistic peers. Students’ experiences of stigma from staff and peers, and the masking behaviors they deploy to minimize it, can also result in worsening mental health. Despite these concerns, there is a lack of tailored support for autistic students at university. The current project assesses a co-created training course for university staff focused on debunking stereotypes, educating about the autistic experience at university, mental health presentation among autistic individuals, and practical strategies to improve interactions with autistic students.MethodsThe Autism Stigma and Knowledge Questionnaire [ASK-Q] was administered before and after the training, to examine changes in trainees’ understanding and acceptance of autism and autistic people. Post-training interviews and surveys were also conducted with trainees, covering the impact the training has had on their perceptions of autism, the strategies they found beneficial, and how they will use the materials in future.ResultsThere were no statistically significant differences between pre- and post-training scores on the ASK-Q, likely due to ceiling effects as pre-training scores were high. Thematic analysis of interviews identified five themes: value of lived experience; developing nuanced, in-depth knowledge of autism; training as acceptable and feasible; links to professional practice; and systemic barriers.ConclusionAlthough ceiling effects meant there were no changes to participant’s knowledge about autism and autistic people statistically, the qualitative data reveals the extensive benefits they gained from taking part in the training programs. Scoring highly on the ASK-Q did not mean that people could not learn important new information and benefit from the course. This more nuanced understanding of autism led to practical changes in their practice. Listening to and learning from autistic people was seen as particularly important, highlighting the value of co-production. Our results also emphasize the need for varied approaches to evaluating training effectiveness, as reliance on quantitative data alone would have missed the subtler, but impactful, changes our participants experienced. This has important implications for professional practice, both within higher education and more broadly.
Case report: Long-term management of occlusion after surgical-orthodontic treatment for a patient with drug-induced open bite developed after the onset of schizophrenia
Authors: Takada Jun-Ichi , Higashihori Norihisa , Kadota-Watanabe Chiho , Kawamoto Tatsuo , Toyofuku Akira , Moriyama Keiji 
Published: December 2023

BackgroundSchizophrenia is a major mental disorder, with an estimated incidence of 1%. Since they are sensitive to sensory changes, orthodontic treatment to move teeth should be avoided as aggressively as possible in these patients because of strong concerns about the possibility of causing adverse psychological effects, thus there are few reports on orthodontic treatment for schizophrenia patients. We report a case of severe open bite caused by medication after the onset of schizophrenia, even though the patient’s occlusion had been stable for a long time after surgical orthodontic treatment. Medication control and the use of a minimally invasive orthodontic appliance improved the occlusion without adversely affecting the patient’s mental health.CaseA 22-year-old woman presented to the clinic with a chief complaint of an anterior open bite. Intraoral findings showed an overbite (vertical overlap of the incisor teeth) of −3.0 mm and an overjet (horizontal overlap of the incisor teeth) of −0.5 mm. The preoperative orthodontic treatment included bilateral extraction of the maxillary first premolars. Subsequently, orthognathic surgery was performed to achieve a harmonized skeletal relationship and occlusion. Occlusion was stable for 3 years after surgery. However, 10 years after surgery, the patient returned to the clinic complaining of an anterior open bite (overbite = −4.0 mm). Six years prior to the return, the patient was diagnosed with schizophrenia. We thought that ignoring the patient’s strong desire to treat her open bite might also cause psychological problems; therefore, in addition to medication control, we treated her using a minimally invasive removable orthodontic appliance (retainer with tongue crib). Her anterior open bite improved (overbite, +1.0 mm) to within the normal range.ConclusionIn this case, medication control was thought to be essential to improve her drug-induced open bite. However, minimally invasive orthodontic treatment, such as the use of a removable appliance, might be helpful in promoting her mental stability as well as for improving occlusion. Careful support is required to obtain information about the patient’s mental state and medications through close cooperation with psychiatrists.
Resilience, organizational support, and innovative behavior on nurses’ work engagement: a moderated mediation analysis
Authors: Zhou Feiyang , Long Keyu , Shen Haiyan , Yang Zixuan , Yang Tingting , Deng Lu , Zhang Jie 
Published: December 2023

ObjectivesTo investigate the status of nurses’ work engagement and the relationship among resilience, organizational support, and innovative behaviors.MethodsIn this cross-sectional study, we investigated 496 nurses in Hunan, China, from July 2022 to December 2022. A descriptive statistical approach, Pearson’s correlation analysis and Hayes’ PROCESS Macro Models 4 and 14 were used to analyze the available data.ResultsThe level of work engagement among nurses was found to be moderate. Resilience positively predicted work engagement among nurses. Organizational support played a partially mediating role in the association between resilience and work engagement. Furthermore, innovative behavior played a moderating role in the association between adaptive resilience and work engagement.ConclusionBased on the results, greater attention needs to be paid to nurses’ work engagement. A high level of resilience, organizational support, and innovative behavior may increase work engagement among nurses. Nursing leaders can take measures to increase work engagement among nurses by improving nurses’ resilience and organizational support, and cultivating innovative behavior.