bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro and In Vivo Evaluation of 3D Printed Poly(Ethylene Glycol) Dimethacrylate‐Based Photocurable Hydrogel Platform for Bone Tissue Engineering
Authors: Unagolla Janitha M. , Gaihre Bipin , Jayasuriya Ambalangodage C. 
Published: December 2023

AbstractThis study focuses to develop a unique hybrid hydrogel bioink formulation that incorporates poly(ethylene glycol) dimethacrylate (PEGDMA), gelatin (Gel), and methylcellulose (MC). This formulation achieves the necessary viscosity for extrusion‐based three‐dimensional (3D) printing of scaffolds intended for bone regeneration. After thorough optimization of the hybrid bioink system with Gel, three distinct scaffold groups are investigated in vitro: 0%, 3%, and 6% (w/v) Gel. These scaffold groups are examined for their morphology, mechanical strength, biodegradation, in vitro cell proliferation and differentiation, and in vivo bone formation using a rat cranial defect model. Among these scaffold compositions, the 3% Gel scaffold exhibits the most favorable characteristics, prompting further evaluation as a rat mesenchymal stem cell (rMSC) carrier in a critical‐size cranial defect within a Lewis rat model. The compressive strength of all three scaffold groups range between 1 and 2 MPa. Notably, the inclusion of Gel in the scaffolds leads to enhanced bioactivity and cell adhesion. The Gel‐containing scaffolds notably amplify osteogenic differentiation, as evidenced by alkaline phosphatase (ALP) and Western blot analyses. The in vivo results, as depicted by microcomputed tomography, showcase augmented osteogenesis within cell‐seeded scaffolds, thus validating this innovative PEGDMA‐based scaffold system as a promising candidate for cranial bone defect healing.
Evaluation of Doped Polyaniline as Potential Sensing Materials and/or Absorbents For Styrene and Phthalates in Aqueous Solutions
Authors: Tourne D. Reese , Jones Jordan J. , Atwater Alex J. , Stewart Katherine M. E. 
Published: December 2023

AbstractThe removal and detection of toxic analytes, including monomers and plasticizers, is important for both health and the environment. Potential absorbents and/or sensing materials are successfully made from polyaniline (PANI) and PANI doped with 10 wt.% of aluminum oxide (PANI‐Al2O3) and titanium dioxide (PANI‐TiO2). The amount of metal oxide incorporated into the surface layers of the polymer and the total amount incorporated are confirmed by energy dispersive X‐rays (EDX) and microwave plasma‐ atomic emission spectroscopy (MP‐AES), respectively. All three materials are evaluated as potential sensing materials and/or absorbents for styrene, monobutyl phthalate (MBP), and dibutyl phthalate (DBP) at 100 ppm in aqueous solutions. It is found that incorporating TiO2 into PANI improved both the sensitivity and selectivity to styrene, making PANI‐TiO2 a good absorbent and potential sensing material for styrene. Additionally, incorporating Al2O3 into PANI improved the sorption to MBP, but reduced the selectivity. As a proof‐of‐concept, the responses of the polymeric nanocomposites are combined and analyzed using principal component analysis (PCA) as such an algorithm. The output reveals good separation of the responses to each analyte, thereby demonstrating how sensing materials with poorer selectivity can be used together to overcome limitations in selectivity.
SPI1‐mediated CXCL12 expression in bladder cancer affects the recruitment of tumor‐associated macrophages
Authors: Lu Guimei , Qiu Yue 
Published: December 2023

AbstractBladder cancer (BC) originates principally from the epithelial compartment of the bladder. The immune system and its diverse players, chemokines, in particular, have been related to the responses against BC. The goal of the study here was to examine if C‐X‐C motif chemokine 12 (CXCL12) in BC cells could manipulate protumorigenic properties of tumor‐associated macrophages (TAMs) which affects anticancer immunity supporting tumor development in the tumor microenvironment. CXCL12 was found to be overexpressed in BC and predicted poor survival. CXCL12 in BC was associated with multiple immune cell infiltrations, with TAM infiltration playing a key role. CXCL12 elevated chemotaxis of TAMs. CXCL12 downregulation inhibited cellular activity and TAM and suppressed the ability of TAMs to secrete inflammatory factors and MMP9. Furthermore, chromatin immunoprecipitation analysis revealed that SPI1 was localized to the CXCL12 promoter in BC cells, suggesting that CXCL12 serves a direct target of SPI1, which was consistent with the fact that SPI1 reversed the repressive effects of si‐CXCL12 on BC cell activity and TAM recruitment in vitro and in vivo. Collectively, these findings suggest that SPI1 is involved in modulating TAM recruitment, representing a new mechanism through which it may influence tumor growth. This may be partly mediated by regulating CXCL12 expression.
Genetic analysis and literature review of a Poirier–Bienvenu neurodevelopmental syndrome family line caused by a de novo frameshift variant in CSNK2B
Authors: Li Danyang , Zhou Bingbo , Tian Xinyuan , Chen Xue , Wang Yupei , Hao Shengju , Zhang Chuan , Hui Ling 
Published: December 2023

AbstractBackgroundPoirier–Bienvenu neurodevelopmental syndrome (POBINDS) is a rare autosomal dominant neurologic disorder caused by a heterozygous variant of CSNK2B, which is characterized by early onset epilepsy, hypotonia, varying degrees of intellectual disability (ID), developmental delay (DD), and facial dysmorphism. This study clarifies the molecular diagnosis and causative factors of a Chinese boy with POBINDS.MethodsThe clinical phenotypes and ancillary laboratory tests were collected and analyzed by trio whole exome sequencing (WES) and copy number variant sequencing (CNV‐seq) in the follow‐up proband's families. The candidate variant was validated by Sanger sequencing and bioinformatics software was used to further explore the effect of the de novo frameshift variant on the protein structure.ResultsThe proband carries a de novo frameshift variant c.453_c.454insAC (p.H152fs*76) in CSNK2B. According to the ACMG genetic variant classification criteria and guidelines, the locus is a pathogenic variant (PVS1+PS2+PM2) and the associated disease was POBINDS. Protein structure prediction suggests significant differences in amino acid sequences before and after mutation.ConclusionA rare case of POBINDS caused by a novel frameshift variant in CSNK2B was diagnosed. The novel variant extends the variation spectrum of CSNK2B, which provides guidance for early clinical diagnosis, genetic counseling and treatment of this family. A review of the currently reported cases of POBINDS further enriches and summarizes the relationship between genotype and phenotype of POBINDS.
Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway
Authors: Xia Yuan , Tan Wei , Yuan Fangting , Lin Mengjuan , Luo Hesheng 
Published: December 2023

ScopeIrritable bowel syndrome (IBS) is an intestinal disorder, whose symptoms can be alleviated by certain dietary phytochemicals. This study explores the role and potential mechanisms of a natural flavonoid luteolin (LUT) in alleviating the excessive motility of colonic smooth muscles and reducing oxidative stress in IBS with diarrhea (IBS‐D) rats.Methods and resultsLUT reduces excessive intestinal motility and lowers reactive oxygen species (ROS) levels in a water avoidance stress (WAS) rat model. Moreover, LUT increases the protein expression levels of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1), activates the nuclear translocation of Nrf2, and greatly reduces the hydrogen peroxide (H2O2)‐induced oxidative damage in intestinal epithelial cells.ConclusionsLUT, a phyto‐active component, protects against excessive intestinal motility and diarrhea by regulating the Nrf2 signaling pathway and effectively reduces oxidative stress damage in the colon.
Design of miniaturized and high gain dielectric lens antenna
Authors: Liang Jia‐Jun , Wu Zhao , Huang Yan Hu , Li Long , Wang Qiang 
Published: December 2023

AbstractA miniaturized and high‐gain dielectric lens antenna is presented and demonstrated. The dielectric lens antenna is mainly composed of a spherical dielectric lens, a pedestal, and a radiating element. The spherical dielectric lens is made of a special material called cross‐linked styrene co‐polymer showing an ultra‐low dielectric loss and a stable permittivity. The pedestal is made by the 3D printing technique and used for supporting the dielectric lens. The radiating element is embedded in the bottom of the pedestal, a proper spacing between the dielectric lens and the radiating element is maintained. The proposed dielectric lens antenna shows impedance bandwidth ranging from 24.4 to 25.8 GHz and an excellent directional radiation characteristic is obtained.
Towards a circular economy with waste‐to‐resource system optimization
Authors: Ng Tsan Sheng Adam , Mah Angel Xin Yee , Zhao Kena 
Published: December 2023

AbstractMotivated by mounting pressures to achieve environmental sustainability, and the emergence of online waste exchange platforms, in this work we propose an optimization‐based framework for studying waste‐to‐resource formation in the industry. We first develop a linear programming market clearing model comprising self‐interested agents participating in waste‐to‐resource trading. We then embed this in a bi‐level capacity optimization problem under uncertainties in the agents' reserve prices, the goal of which is to maximize the economic savings achieved by waste‐to‐resource. We show that the resulting robust optimization models admit linear mixed integer programming formulations that can be readily computed using available solvers. Furthermore, we provide the formulas for applying an equitable levy and incentive scheme, to enable capacity cost‐sharing among the agents. Numerical studies based on a case of organic waste streams demonstrate the usefulness of the proposed models in generating valuable insights for decision support in the design of waste‐to‐resource markets.
Blockage‐free storage assignment and storage/retrieval scheduling in autonomous vehicle storage and retrieval systems
Authors: Chen Ran , De Koster René , Yu Yugang , Guo Xiaolong , Yu Hu 
Published: December 2023

AbstractAutonomous vehicle storage and retrieval systems have greatly increased in popularity in the last decade. In such a system, at each tier multiple roaming vehicles transport totes between the storage locations and the lifts. However, this may lead to vehicle interference. We study in which order and by which vehicle the storage and retrieval requests should be executed to minimize the makespan, without vehicle interference. The optimal storage locations for incoming totes are also determined. A blocking mitigation protocol is proposed to address vehicle interference. We propose a two‐phase matheuristic, where in the first phase, the tier is divided into zones, with each zone assigned its own vehicle. The second phase focuses on reassigning requests between adjacent vehicles to obtain improved solutions. The models proposed in both phases are solved to optimality in polynomial time and pseudo‐polynomial time, respectively. Computational experiments show that the matheuristic produces high‐quality solutions within a few seconds, even for large‐sized instances, making it suitable for real‐time decisions. Compared to methods commonly used in practice, our matheuristic can reduce the makespan by up to 15%. Our results show that making integrated decisions that combine storage assignment and request scheduling, is more beneficial than sequential optimization in terms of throughput performance, space utilization and overall system cost. We also find that increasing the number of vehicles has a diminishing return effect on the makespan. Another finding is that the system with a large number of short storage aisles leads to higher throughput capacity than that with a small number of long storage aisles.
Association Between Hearing Difficulty and Mobility in Adults of All Ages: National Health Interview Survey
Authors: Joo Henry H. , Huang Emily Y. , Schoo Desi , Ward Bryan , Chen Jenny X. 
Published: December 2023

AbstractObjectiveTo investigate the relationship between hearing difficulty and measures of mobility for US adults.Study DesignCross‐sectional study.Setting2021 National Health Interview Survey.MethodsThe survey asked US adults about hearing difficulty and mobility measures, including difficulty walking 100 yards, difficulty climbing 12 steps, and injury from falling within the past 3 months. Multivariable logistic regressions examined the associations between hearing and mobility outcomes, controlling for visual difficulty, medical comorbidities, and various demographic characteristics (age [18‐39, 40‐64, 65+], race/ethnicity, sex, socioeconomic status).ResultsThe 2021 NHIS surveyed 29,467 adults, representing 253 million people in weighted responses (52% female; mean age 48.3, standard deviation = 18.6). Controlling for covariates, hearing difficulty was associated with increased odds of difficulty walking 100 yards (odds ratio, OR = 1.47, P < .001), difficulty climbing stairs (OR = 1.62, P < .001), and injury from falling in the past 3 months (OR = 1.51, P < .001). There was a significant interaction between age and hearing difficulty for injurious falls; stratifying by age revealed that younger adults (ages 18‐39) with hearing difficulty were more likely to report recent harmful falls than their normal hearing peers; this increased risk was greater in magnitude than that observed comparing older adults with and without hearing difficulty.ConclusionThe hearing difficulty is associated with worsened mobility for US adults and may be a stronger independent predictor of injury from falls for younger adults as compared to older adults. These findings can inform interventions to reduce the burden of declining mobility in adults with hearing difficulty.
Multi‐dimensional stimulus response organic silicone polymer elastomer and its application
Authors: Lu Jun‐jian , Yang Zheng‐peng , Liu Xin , Lu Guang‐zhao 
Published: December 2023

AbstractThis work investigated the influence of melamine up to 15 wt% on the stimulation response properties of organic silicone polymer elastomer. The opacity of organic silicone film was attributed to the addition of melamine. For silicone and melamine composite thin films, deformation was increased from 152 to 172%, because the density of NH···O type hydrogen bond decreased the thermal motion of the polymer chain. The thin film of fluorescence and phosphorescence spectra indicated that the maximum luminescence wavelength red‐shifted about 14 nm. The Elastomer with melamine exhibited two‐dimensional stimulus response performance with the change of scale shape‐time‐afterglow emission properties. The phosphorescence of the silicone composite film was derived from the energy donor of melamine. In summary, the study provides detailed guidelines for the preparation of multi‐dimensional organic room temperature phosphorescent elastic materials.
Prediction of family‐centered care on the unmet care needs of parents of pediatric oncology patients and their psychosocial problems
Authors: Ay Ayşe , Semerci Remziye , Erkul Münevver 
Published: December 2023

AbstractBackground/objectivesIt was aimed to determine the predictive power of family‐centered care of parents of children with cancer on their unmet care needs and psychosocial problems (anxiety, depression, stress). This study was conducted as a descriptive, correlational, and cross‐sectional study.Design/methodsThe study was conducted on 136 parents at a university hospital between January and September 2023, involving parents of children receiving care at the pediatric oncology clinic. Data collection instruments included an Information Form, Family Inventory of Needs Pediatric II (FINPED‐II), Family‐Centered Care Scale (FCCS), and Depression Anxiety Stress Scale (DASS‐21). Data were analyzed using IBM SPSS 28, employing Pearson correlation analysis and linear regression to assess the relationships between variables.ResultsThe study revealed significant positive correlations between Family‐Centered Care and Met Needs (r = .676, p < .001) and significant negative correlations between Met Needs and Stress scores (r = −.256, p < .001). Additionally, there were positive correlations between Anxiety and Depression scores (r = .700, p < .001), Anxiety and Stress scores (r = .768, p < .001), and Depression and Stress scores (r = .835, p < .001). Family‐centered care significantly predicted Met Needs (p < .001) and accounted for 47% of the variation in Anxiety, Depression, Stress, and Family Inventory of Needs scores.ConclusionThe findings highlight that family‐centered care significantly predicts Met Needs, emphasizing its pivotal role in supporting parents of children with cancer. These findings underscore the importance of family‐centered care in pediatric oncology, but also point to the need for further studies to address identified limitations and provide a comprehensive understanding of this complex healthcare dynamic.
Boron nitride nanosheet @ quantum‐sized diamond nanocrystal complex/epoxy nanocomposites with enhancing thermal conductivity and sufficient dielectric breakdown strength
Authors: Wang Zhengdong , Zhou Yuanhang , Zhang Tong , Luo Meng , Cao Xiaolong , Yang Ganqiu , Sun Wei 
Published: December 2023

AbstractWith the development of high‐voltage and high‐power devices in the direction of compactness, lightness and extreme working environments, the contradiction between thermal conductivity and dielectric breakdown strength is becoming more and more obvious. In this work, a novel boron nitride nanosheet with uniformly dispersed diamond nanocrystalline (abbreviated as BA@DN) was prepared via facile acidizing hydroxylation, in situ copolymerization self‐assembly of dopamine and blending process. The obtained hybrid filler was employed to embed into epoxy matrix, showing enhanced thermal conductivity and sufficient dielectric breakdown strength. For example, the through‐plane and in‐plane thermal conductivity of epoxy composite with 5% BA@DN‐2 reaches to 0.56 and 3.824 W/m K, respectively. The study proposes a modified plane thermal conductivity model. Based on calculations, it was found that the modified thermal conductivity of 5% BA@DN‐2 is 3.47 W/m K, which is significantly higher than that of pure EP, specifically 17.35 times higher. These findings are significant in terms of materials science. while its alternating current and direct current dielectric breakdown strength are 48.84 and 136.31 kV/mm, about 85.68% and 99.1% of pure epoxy, respectively. The mechanism of outstanding dielectric breakdown strength was analyzed via dielectric characteristic, partial discharge performance and the theory of quantum size effect. In addition, a modified multi‐core model with a multilevel overlapping interface is presented.Highlights
The acidified diamond nanocrystals (DNs) were attached to dopamine‐coated boron nitride nanocrystals by a blending process.
The small size effect of DNs allows the epoxy film to have both high thermal conductivity and high insulation properties.
A thermal conductivity correction model is proposed to eliminate the effect of graphite layer on the film.
Synthesis, kinetic study and characterization of C5‐dienes/styrene copolymers via living anionic polymerization in cyclopentyl methyl ether solvent
Authors: Fu Yawen , Yang Shuai , Xiong Qiaoqiao , Gu Zhuowei , Dai Qiqi , Tan Haoyun , Zhou Le , Geng Menghan , Xie Fengli , Yi Wen‐jun , Li Lijun , Liu Kun 
Published: December 2023

Abstract1,3‐Dienes/styrene sequence‐controlled copolymers are widely used as thermoplastic elastomers, transparent impact resin and synthetic rubber and other materials. In this work, the binary anionic copolymerization of styrene (S) and C5‐dienes including 1,3‐pentadiene (P, E/Z = 65/35) and isoprene (I) were studied in cyclopentyl methyl ether (CPME) ‘green’ solvent using n‐BuLi as initiator, and the effects of copolymerization monomer ratio and polar additive (PA) on the copolymerization kinetics and monomer sequence distributions were investigated. The kinetic analysis results showed that all copolymerization systems were the first‐order reaction and the C5‐dienes/S could be quantitatively consumed. The addition of S or I was conducive to the efficient conversion of P. Although the addition of PAs had little effect on the polymerization rate, it had a great influence on the microstructure and sequence distribution of the copolymer. 1H NMR tracking analysis showed that, for S/P copolymerization with different feeding ratios 1/3 < fP < 2/3, the instant composition FP in the copolymer remained relatively constant at 15% < FP < 35% when the monomer conversion rate was below 60%, and thus the inevitable formation of P microblocks in subsequent polymerization sequences was observed. Additionally, similar sequence distributions were obtained in the case of I/P copolymerization systems. By contrast, S/I copolymerization conformed to the typical random copolymerization pattern, and the copolymerization activity of S was slightly higher than that of the I in CPME. The use of strong PAs such as 2,2‐di(2‐tetrahydrofuran)propane directly resulted in a change of monomer sequence from a random pattern to a gradual block pattern. Moreover, the 3,4‐isoprene branch units were much more sensitive to solvent and PA than 1,2‐pentadiene units for C5‐dienes; also Fourier transform infrared and DSC analysis verified the microstructure and sequence analysis results mentioned above. In addition, the results of gel permeation chromatography showed that the copolymerization process in CPME had excellent controllable characteristics. © 2023 Society of Industrial Chemistry.
Photosynthetically active radiation is required for seedling growth promotion by volcanic dacitic tuff breccia (Azomite)
Authors: McCue Kent F. , Mehlferber Elijah , Reed Robert , Ortiz Alexis , Ferrel Jon , Khanna Rajnish 
Published: December 2023

AbstractA plant's growth and development are shaped by its genome and the capacity to negotiate its environment for access to light, water, and nutrients. There is a vital need to understand the interactions between the plant, its physical environment, and the fertilizers used in agriculture. In this study, a commercially available volcanic ash fertilizer, Azomite®, characterized as dacitic (rhyolitic) tuff breccia, was tested for its effect on promoting early seedling vigor. Early growth and photomorphogenesis processes are well studied in Arabidopsis. Seedling assays under different light conditions were used to dissect the underlying mechanisms involved. These assays are well established and can be translated to agriculturally important crop plants. The volcanic ash fertilizer was tested at different concentrations on seedlings grown on basic media lacking sucrose either in continuous darkness (Dc), continuous Red (Rc), Far‐Red (FRc), or White Light (WLc). Micronutrients in the volcanic ash significantly increased seedling growth under Rc and WLc, but not under Dc and FRc, indicating that photosynthetically active radiation was required for the observed growth increase. Furthermore, red‐light photoreceptor mutant, phyB‐9, lacked the growth response, and higher amount of fertilizer reduced growth in all conditions tested. These data suggest that light triggers the ability of the seedling to utilize micronutrients in volcanic ash in a dose‐dependent manner. The methods described here can be used to establish mechanisms of activity of various nutrient inputs and, coupled with whole‐genome expression profiling, can lead to better insights into optimizing nutrient field applications to improve crop production.