bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study
Authors: Hundemer Gregory L. , Agharazii Mohsen , Madore François , Vaidya Anand , Brown Jenifer M. , Leung Alexander A. , Kline Gregory A. , Larose Eric , Piché Marie-Eve , Crean Andrew M. , Shaw Julie L.V. , Ramsay Tim , Hametner Bernhard , Wassertheurer Siegfried , Sood Manish M. , Hiremath Swapnil , Ruzicka Marcel , Goupil Rémi 
Published: November 2023

BACKGROUND:
Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder and subclinical forms of primary aldosteronism are highly prevalent, yet their contribution to cardiovascular disease is not well characterized.

METHODS:
This prospective study included 1284 participants between the ages of 40 and 69 years from the randomly sampled population-based CARTaGENE cohort (Québec, Canada). Regression models were used to analyze associations of aldosterone, renin, and the aldosterone-to-renin ratio with the following measures of cardiovascular health: arterial stiffness, assessed by central blood pressure (BP) and pulse wave velocity; adverse cardiac remodeling, captured by cardiac magnetic resonance imaging, including indexed maximum left atrial volume, left ventricular mass index, left ventricular remodeling index, and left ventricular hypertrophy; and incident hypertension.

RESULTS:

The mean (SD) age of participants was 54 (8) years and 51% were men. The mean (SD) systolic and diastolic BP were 123 (15) and 72 (10) mm Hg, respectively. At baseline, 736 participants (57%) had normal BP and 548 (43%) had hypertension. Higher aldosterone-to-renin ratio, indicative of renin-independent aldosteronism (ie, subclinical primary aldosteronism), was associated with increased arterial stiffness, including increased central BP and pulse wave velocity, along with adverse cardiac remodeling, including increased indexed maximum left atrial volume, left ventricular mass index, and left ventricular remodeling index (all
P
<0.05). Higher aldosterone-to-renin ratio was also associated with higher odds of left ventricular hypertrophy (odds ratio, 1.32 [95% CI, 1.002–1.73]) and higher odds of developing incident hypertension (odds ratio, 1.29 [95% CI, 1.03–1.62]). All the associations were consistent when assessing participants with normal BP in isolation and were independent of brachial BP.

CONCLUSIONS:
Independent of brachial BP, a biochemical phenotype of subclinical primary aldosteronism is negatively associated with cardiovascular health, including greater arterial stiffness, adverse cardiac remodeling, and incident hypertension.
Prediction, Explanation, and Control: The Use of Mental Models in Dynamic Environments
Authors: Tikhonov Roman , DeDeo Simon 
Published: November 2023

Abstract
The abilities to predict, explain, and control might arise out of operations on a common underlying representation or, conversely, from independent cognitive processes. We developed a novel experimental paradigm to explore how individuals might use probabilistic mental models in these three tasks, under varying levels of complexity and uncertainty. Participants interacted with a simple chatbot defined by a finite-state machine, and were then tested on their ability to predict, explain, and control the chatbot’s responses. When full information was available, performance varied significantly across the tasks, with control proving most robust to increased complexity, and explanation being the most challenging. In the presence of hidden information, however, performance across tasks equalized, and participants demonstrated an alternative neglect bias, i.e., a tendency to ignore less likely possibilities. A second, within-subject experimental design then looked for correlations between abilities. We did not find strong correlations, but the challenges of the task for the subjects limited our statistical power. To understand these effects better, a final experiment investigated the possibility of cross-training, skill transfer, or “zero-shot” performance: how well a participant, explicitly trained on one of the three tasks, could perform on the others without additional training. Here we found strong asymmetries: participants trained to control gained generalizable abilities to both predict and explain, while training on either prediction or explanation did not lead to transfer. This cross-training experiment also revealed correlations in performance; most notably between control and prediction. Our findings highlight the complex role of mental models, in contrast to task-specific heuristics, when information is partially hidden, and suggest new avenues for research into situations where the acquisition of general purpose mental models may provide a unifying explanation for a variety of cognitive abilities.
Direct and Observed Joint Attention Modulate 9-Month-Old Infants’ Object Encoding
Authors: Thiele Maleen , Kalinke Steven , Michel Christine , Haun Daniel B. M. 
Published: November 2023

Abstract
Sharing joint visual attention to an object with another person biases infants to encode qualitatively different object properties compared to a parallel attention situation lacking interpersonal sharedness. This study investigated whether merely observing joint attention amongst others shows the same effect. In Experiment 1 (first-party replication experiment), N = 36 9-month-old German infants were presented with a violation-of-expectation task during which they saw an adult looking either in the direction of the infant (eye contact) or to the side (no eye contact) before and after looking at an object. Following an occlusion phase, infants saw one of three different outcomes: the same object reappeared at the same screen position (no change), the same object reappeared at a novel position (location change), or a novel object appeared at the same position (identity change). We found that infants looked longer at identity change outcomes (vs. no changes) in the “eye contact” condition compared to the “no eye contact” condition. In contrast, infants’ response to location changes was not influenced by the presence of eye contact. In Experiment 2, we found the same result pattern in a matched third-party design, in which another sample of N = 36 9-month-old German infants saw two adults establishing eye contact (or no eye contact) before alternating their gaze between an object and their partner without ever looking at the infant. These findings indicate that infants learn similarly from interacting with others and observing others interact, suggesting that infant cultural learning extends beyond infant-directed interactions.
Oversight Functions of the National Assembly and Good Governance in Tanzania: a Missing Link?
Authors: Makulilo Victoria B. 
Published: November 2023

Abstract
Oversight is considered a part of good governance. While good governance aims to minimise corruption, consider people’s opinions, listen to the voices of the oppressed in the decision-making process, and respond actively to the community’s needs, oversight maintains a watchful eye on an individual and the process. Oversight institutions monitor and review actions of government organs. With the use of key informed interviews with members of parliament, chairpersons of various oversight committees, chairpersons of parliamentary groups or caucuses, experts, selected civil society Organisations (CSOs), and the general public, this paper aimed at explaining the extent to which the Tanzania’s National Assembly effectively oversees the executive organ of the government. It notes that despite its impressive performance as a representative body since the introduction of multiparty democracy in 1992, the parliament is under one-party dominance and a powerful executive, making oversight functions relatively ineffective. The findings further show that the Parliament is under-resourced and is male-dominated. This paper suggests parliamentary support mechanisms to strengthening institutional and operational independence vis-à-vis the executive; and effectively engage the civil society, experts and the public in the work of the National Assembly.
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Authors: Spasevska Ivana , Sharma Ankush , Steen Chloé B. , Josefsson Sarah E. , Blaker Yngvild N. , Kolstad Arne , Rustad Even H. , Meyer Saskia , Isaksen Kathrine , Chellappa Stalin , Kushekhar Kushi , Beiske Klaus , Førsund Mette S. , Spetalen Signe , Holte Harald , Østenstad Bjørn , Brodtkorb Marianne , Kimby Eva , Olweus Johanna , Taskén Kjetil , Newman Aaron M. , Lorenz Susanne , Smeland Erlend B. , Alizadeh Ash A. , Huse Kanutte , Myklebust June H. 
Published: November 2023

Abstract
Tumor-infiltrating regulatory T cells (Tregs) contribute to an immunosuppressive tumor microenvironment. Despite extensive studies, the prognostic impact of tumor-infiltrating Tregs in B-cell non-Hodgkin lymphomas (B-NHLs) remains unclear. Emerging studies suggest substantial heterogeneity in the phenotypes and suppressive capacities of Tregs, emphasizing the importance of understanding Treg diversity and the need for additional markers to identify highly suppressive Tregs. Here, we applied single-cell RNA sequencing and T-cell receptor sequencing combined with high-dimensional cytometry to decipher the heterogeneity of intratumoral Tregs in diffuse large B-cell lymphoma and follicular lymphoma (FL), compared with that in nonmalignant tonsillar tissue. We identified 3 distinct transcriptional states of Tregs: resting, activated, and unconventional LAG3+FOXP3− Tregs. Activated Tregs were enriched in B-NHL tumors, coexpressed several checkpoint receptors, and had stronger immunosuppressive activity compared with resting Tregs. In FL, activated Tregs were found in closer proximity to CD4+ and CD8+ T cells than other cell types. Furthermore, we used a computational approach to develop unique gene signature matrices, which were used to enumerate each Treg subset in cohorts with bulk gene expression data. In 2 independent FL cohorts, activated Tregs was the major subset, and high abundance was associated with adverse outcome. This study demonstrates that Tregs infiltrating B-NHL tumors are transcriptionally and functionally diverse. Highly immunosuppressive activated Tregs were enriched in tumor tissue but absent in the peripheral blood. Our data suggest that a deeper understanding of Treg heterogeneity in B-NHL could open new paths for rational drug design, facilitating selective targeting to improve antitumor immunity.
Plant exosomes: nano conveyors of pathogen resistance
Authors: Subha D. , AnuKiruthika R. , Sreeraj Harsha , Tamilselvi K. S. 
Published: November 2023

AbstractThe entry of a pathogen into a plant host is a complex process involving multiple steps. Survival techniques from the pathogen and the defense mechanisms of the plant lead to a plethora of molecular interactions during the operation. Plant extracellular vesicles, especially the exosomes in the size range of 50–150 nm play a crucial role in plant defense. They act as signalosomes capable of transporting bioactive lipids, proteins, RNA and metabolites between the host and the pathogen. Recent research works have revealed that anti-microbial compounds, stress response proteins and small RNA are among the contents of these extracellular vesicles. The current review article analyses the cruciality of the cross-talk between the host and the pathogen organized through trafficking of small RNA via exosomes towards RNA induced gene silencing in the pathogenic organisms. Recent studies have shown that extracellular vesicles released by both plants and the pathogens, play a crucial role in cross-kingdom communication, thereby regulating the host response and contributing to plant immunity. An in-depth understanding of the mechanism by which the EVs mediate this inter-species and cross-kingdom regulation is currently needed to develop sustainable plant-protection strategies. The review highlights on the latest advances in understanding the role of EVs in establishing host–pathogen relationship, modulating plant immunity and approaches for how these findings can be developed into innovative strategies for crop protection.
PMFFRC: a large-scale genomic short reads compression optimizer via memory modeling and redundant clustering
Authors: Sun Hui , Zheng Yingfeng , Xie Haonan , Ma Huidong , Liu Xiaoguang , Wang Gang 
Published: November 2023

Abstract
Background
Genomic sequencing reads compressors are essential for balancing high-throughput sequencing short reads generation speed, large-scale genomic data sharing, and infrastructure storage expenditure. However, most existing short reads compressors rarely utilize big-memory systems and duplicative information between diverse sequencing files to achieve a higher compression ratio for conserving reads data storage space.

Results
We employ compression ratio as the optimization objective and propose a large-scale genomic sequencing short reads data compression optimizer, named PMFFRC, through novelty memory modeling and redundant reads clustering technologies. By cascading PMFFRC, in 982 GB fastq format sequencing data, with 274 GB and 3.3 billion short reads, the state-of-the-art and reference-free compressors HARC, SPRING, Mstcom, and FastqCLS achieve 77.89%, 77.56%, 73.51%, and 29.36% average maximum compression ratio gains, respectively. PMFFRC saves 39.41%, 41.62%, 40.99%, and 20.19% of storage space sizes compared with the four unoptimized compressors.

Conclusions
PMFFRC rational usage big-memory of compression server, effectively saving the sequencing reads data storage space sizes, which relieves the basic storage facilities costs and community sharing transmitting overhead. Our work furnishes a novel solution for improving sequencing reads compression and saving storage space. The proposed PMFFRC algorithm is packaged in a same-name Linux toolkit, available un-limited at https://github.com/fahaihi/PMFFRC.
Meta-analysis of clinical adverse events after CABG vs. PCI in patients with chronic kidney disease and coronary artery disease
Authors: Luo Cheng , wang Qiang , Nong Shuxiong , Chen Yushan , Li Longchang , Gui Chun 
Published: November 2023

Abstract
Aim
To investigate the efficacy and postoperative clinical adverse events of coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for chronic kidney disease (CKD) study participants combined with coronary artery disease (CAD).

Methods
All randomized controlled trials (RCTs) that focus on the therapeutic effect evaluation of CABG and PCI and their effect on postoperative clinical adverse events as well as main adverse cardiovascular and cerebrovascular events (MACCEs) in CKD study participants with CAD were screened from the following databases, including CNKI, CBM, Wan Fang, VIP, Embase, PubMed, as well as Cochrane library clinical controlled trials. The study was conducted under the PRISMA 2020 criteria. Data were extracted, and quality control was evaluated from the modified Jadad rating scale. Meta-analysis was then undertaken through STATA 16.0 software.

Results
A total of 5 RCTs were obtained, including 1198 patients. Study participants were subdivided into two groups, including the PCI group (n = 604) and the CABG group (n = 594). Meta-analysis of clinical adverse events results showed that the long-term survival results of CAD patients with CKD who underwent PCI were worsened compared to CABG, such as long-term MACCEs (RR = 1.59, 95%CI: 1.04–2.43) and the long-term repeated revascularization (RR = 2.48, 95%CI: 1.76–3.49). Also, cardiac death (RR = 1.68, 95%CI:1.04–2.71), as well as cerebrovascular accident (RR = 1.74, 95%CI:1.04–2.90) in CABG group was significantly lower than that in PCI group.

Conclusion
This meta-analysis showed that CABG provided a better therapeutic effect than PCI in CKD patients with CAD when considering long-term prognosis. However, more prospective RCTs are needed to define the proper revascularization strategy for CAD patients with CKD.
Right atrial wall inflammation detected by 18F-FDG PET/CT may be significantly associated with persistent atrial fibrillation: a prospective case-control study
Authors: Wan Peng , Wang Bing , Yu Wenji , Zhai Li Shang , Qian Bo , Zhang Feifei , Liu Bao , Wang Jianfeng , Shao Xiaoliang , Shi Yunmei , Jiang Qi , Wang Meng Fei , Shao Shan , Wang Yuetao 
Published: November 2023

Abstract
Aim
Atrial fibrillation (AF) is a progressive disease from paroxysmal to persistent, and persistent AF (PerAF) had worse prognosis. AF has potential link with inflammation, but it is not clear whether PerAF or paroxysmal AF (ParAF) is more closely related to inflammation. On the basis of inhibiting myocardial physiological uptake, 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) is an established imaging modality to detect cardiac inflammation. We aimed to decipher the association between AF and atrial inflammatory activity by 18F-FDG PET/CT.

Methods
Thirty-five PerAF patients were compared to age and sex matched ParAF group with baseline 18F-FDG PET/CT scans prior to radiofrequency catheter ablation (RFCA) in the prospective case-control study. High-fat and low-carbohydrate diet and prolonged fast (HFLC+Fast) was applied to all AF patients before PET/CT. Then 22 AF patients with positive right atrial (RA) wall FDG uptake (HFLC+Fast) were randomly selected and underwent HFLC+Fast+heparin the next day. The CHA2DS2-VASc score was calculated to evaluate the risk of stroke. Clinical data, ECG, echocardiography, and atrial 18F-FDG uptake were compared.

Results
PerAF patients had significantly higher probability of RA wall positive FDG uptake and higher SUVmax than ParAF group [91.4% VS. 28.6%, P < 0.001; SUVmax: 4.10(3.20–4.90) VS. 2.60(2.40–3.10), P < 0.001]. Multivariate logistic regression analyses demonstrated that RA wall SUVmax was the independent influencing factor of PerAF (OR = 1.80, 95%CI 1.02–3.18, P = 0.04). In 22 AF patients with RA wall positive FDG uptake (HFLC+Fast), the “HFLC+Fast+Heparin” method did not significantly change RA wall FDG uptake evaluated by either quantitative analysis or visual analysis. High CHA2DS2-VASc score group had higher RA wall 18F-FDG uptake [3.35 (2.70, 4.50) vs, 2.8 (2.4, 3.1) P = 0.01].

Conclusions
RA wall FDG positive uptake was present mainly in PerAF. A higher RA wall 18F-FDG uptake was an independent influencing factor of PerAF. RA wall FDG uptake based on 18F-FDG PET/CT may indicate pathological inflammation.

Trial registration
http://www.chictr.org.cn, ChiCTR2000038288.
Foley catheter technique for the extraction of coins lodged in the upper esophagus of children
Authors: Erginel Basak , Kaba Meltem , Karadag Cetin Ali , Yildiz Abdullah , Demir Mesut , Sever Nihat 
Published: November 2023

Abstract
Introduction
Coins are the most commonly ingested foreign bodies in children. They usually become lodged in the upper oesophagus and should be managed immediately. The aim of the present study was to evaluate the characteristics and outcomes of patients with coins lodged in the upper oesophagus, who underwent coin removal using a silicone Foley balloon catheter without fluoroscopy or anaesthesia and evaluate the safety of the procedure.

Materials and methods
Patients who were admitted from January 2007 to December 2022 for coins lodged in the oesophagus and extracted with silicone Foley balloon catheter without anestehesia were evaluated retrospectively. We focused on the patient characteristics and clinical presentations, and the treatment safety, efficacy, and outcomes.

Results
773 patients (416 male, 357 female), with a mean age of 3.5 years (range 6 months to 16 years), who ingested coin and extracted with Foley catether is included. The majority of patients (n = 728, 94.17%) were successfully managed by silicone Foley balloon catheter extraction. Our overall success was 94.17%, with 88.30% of coins retrieved and 5.9% pushed into the stomach. Patients who were successfully treated with Foley catheter were discharged on the same day except for 7 (0.90%) who had minimal bleeding. Only 45 (5.82%) patients required oesophagoscopy in the operating room and these patients were kept overnight for clinical follow-up, without any further interventions.

Conclusion
A Foley balloon catheter can be used to safely and effectively remove coins that are lodged in the upper oesophagus avoiding the risk of general anesthesia.
Quantitative and qualitative assessment of the wear pattern of two attachment systems of dissimilar materials for mandibular implant-retained overdentures: an in-vitro study
Authors: Ramadan Rania E. , Mohamed Faten S. , Abd-Ellah Mervat E. 
Published: November 2023

Abstract
Background
Attachment material is one of the contributing factors to the degree of wear of the attachment components in mandibular implant-retained overdentures. The purpose of this in vitro study was to compare the wear behavior of 2 different attachment systems of dissimilar materials in mandibular implant-retained overdentures by qualitative and quantitative methods.

Methods
Two attachment systems of different materials were utilized (n = 16); Titach (Dental Evolutions Inc, Beverly Hills, CA, USA) with a titanium-to-titanium interface and Locator R-Tx (Zest Anchors Inc, Escondido, CA, USA) with a titanium-to-nylon interface. One thousand cycles of overdenture insertion and removal simulating 1-year clinical use were performed. All matrices were removed from the overdentures and all patrices were unscrewed from the implants for wear assessment quantitively using a stereomicroscope and qualitatively using a scanning electron microscope. Data were analyzed by using an independent sample t test.

Results
After cyclic loading, stereomicroscopic findings showed that the Titach group had statistically significant higher wear value than the Locator R-Tx group (p < 0.001). Moreover, scanning electron microscopy images showed noticeable abrasion in Titach patrix at the area of highest convexity. However, the Locator R-Tx matrix displayed an apparent tear of rubber inserts.

Conclusions
Titach attachment with the titanium-to-titanium interface revealed more wear than Locator R-Tx attachment with the titanium-to-nylon interface. Thus, the type of attachment material influences the degree of wear of the attachment components.