bluuebunny/crossref_metadata_2025_split huggingface dataset:
Juvenile Pacific salmonid habitat use in two Puget Sound lowland rivers
Authors: David Aaron T. , Gregersen Christopher N. , Kubo Joshua S. , Lantz Daniel W. , Bower James W. 
Published: January 2024

Abstract

Objective
Large rivers are complex, productive environments that support numerous species. However, humans have extensively modified these ecosystems, contributing to the decline of Pacific salmonid Oncorhynchus spp. populations. Salmon recovery efforts rely upon an understanding of salmonid habitat needs at different life stages, but data on juvenile salmonid habitat use within large rivers are rare due to the challenges of sampling in large rivers. To help fill this information need, we used a cataraft-mounted electrofisher to evaluate juvenile salmonid use of natural (bar, backwater, side channel, and unarmored bank) and human-modified (riprap-armored bank and biorevetment bank [armored banks with added wood]) channel edge habitats in the Snoqualmie and Green rivers within the Puget Sound region of Washington State.

Methods
We electrofished over 1000 25-m transects across seven spring rearing seasons (2016–2022) and measured transect water depths and widths of low-velocity habitat (≤0.45 m/s).

Result
Bars, backwaters, and side channels were shallower and had wider low-velocity habitat than armored banks. River flow also influenced water depth and low-velocity width, but the relationship varied depending on the habitat type. Subyearling Chinook Salmon O. tshawytscha and subyearling Coho Salmon O. kisutch occurred more frequently and were more abundant along natural edge habitats than along armored banks, while their use of biorevetment banks was intermediate between their use of natural edge habitats and armored banks. In contrast, yearling Coho Salmon and trout occurred more frequently and were more abundant along armored, biorevetment, and unarmored banks than along bars and backwaters, but they also used side channels extensively. Habitat use shifted throughout the spring, but specific shifts varied by species or life history stage.

Conclusion
These results emphasize the importance of conserving natural edge habitats, removing bank armoring, and reconnecting or restoring side channels. Additionally, our results highlight that a diversity of habitat types and conditions is necessary to support multiple species and life history stages.
Calreticulin, a potential coregulator of immune checkpoints and biomarker associated with tumor microenvironment and clinical prognostic significance in breast invasive carcinoma
Authors: Lin Jiali , Chen Yiwei , Zhang Zexin , Qi Feng , Zhang Mingdi 
Published: January 2024

AbstractAs a promising immune checkpoint of immunogenic cell death (ICD) and multifunctional calcium‐binding molecular chaperone, calreticulin (CALR) has been attracting increasing attention. CALR mainly locates in cellular endoplasmic reticulum and significantly affects cell proliferation, invasion, induction of apoptosis, and angiogenesis in breast invasive carcinoma (BRCA). CALR overexpression might be correlated with a worse outcome. Nonetheless, it remains obscure how CALR correlates with immune infiltration and survival prognosis of BRCA. In this study, we investigated CALR expression utilizing RNAseq data from the cancer genome atlas (TCGA) and genotype‐tissue expression (GTEx) database. The prognostic value of CALR was analyzed using clinical survival data. Enrichment analysis was conducted using the R package “clusterProfiler.” We downloaded the immune cell infiltration score of TCGA samples from published articles and online databases and performed a correlation analysis between immune cell infiltration levels and CALR expression. We further assessed the association between CALR and immunomodulators. Moreover, we also evaluated the expression of CALR in 100 formalin‐fixed and paraffin‐embedded breast cancer and adjacent normal breast tissue specimens. Our results found that CALR was highly expressed in BRCA, and CALR expression levels differed in pathological stages, T stages, and N stages. Besides, these results suggested that CALR overexpression may have adverse effects on the progression‐free interval (PFI) and disease‐free interval (DFI), which may be related to tumor proliferation, invasion, and metastasis, leading to tumor deterioration. Meanwhile, immune cell infiltration analysis revealed a correlation between the expression of CALR and the number of neutrophils and dendritic cells, suggesting that CALR was highly correlated with many immunomodulators in BRCA. Our results provide potential biomarkers of CALR in BRCA. CALR may interact synergistically with other immunomodulators to regulate the immune microenvironment, which could be utilized to develop new immunotherapy drugs.
Growth performance, hematological and oxidative stress responses in Nile tilapia (Oreochromis niloticus) exposed to polypropylene microplastics
Authors: Nair Haritha Thulaseedharan , Perumal Siddhuraju 
Published: January 2024

AbstractThe present study investigated the effect of polypropylene (PP) microplastics on the growth performance, hematological profile and oxidative stress responses in the liver and brain tissues of Oreochromis niloticus juvenile. The microplastic exposure was done by offering microplastic‐incorporated feed to the fish. The feed was prepared by mixing microplastics and the feed in three different ratios; Low (1.5 g/kg), Medium (3.0 g/kg), High (4.5 g/kg), and a control with no plastics in it. The trial was done for 7 weeks. A significant impact on the growth performance of the fish was observed in terms of body weight gain, specific growth rate, metabolic growth rate, protein efficiency ratio and energy retention. All the treatments had a significant difference in growth parameters compared to the control. The results of the hematological profile confirmed erythropoietic impairment in the fishes due to high microplastic exposure which led to an anemic condition in the fishes and mortality in the early juvenile stage. The antioxidant enzyme analysis also shows significant oxidative stress induced in liver and brain tissues in a dose‐dependent manner. Exposure to PP microplastics significantly affected the growth, health and metabolism of O. niloticus. Further studies on genetic and cellular levels should be done to elucidate the wide‐ranging effects of MPs on fish species.
Determination and quantification of microplastics in compost
Authors: Iswahyudi Iswahyudi , Widodo Wahyu , Warkoyo Warkoyo , Sutanto Adi , Garfansa Marchel Putra , Septia Erfan Dani 
Published: January 2024

AbstractAlthough microplastics (MPs) in solid organic waste have been intensively studied, the presence of MPs in organic fertilizer and their potential as new emerging pollution to environment because of their use in agriculture has not been explained completely. Therefore, the identification and quantification of MPs in commercially available compost is important. This study aimed to estimate the quantity of MPs in commercial composts. The characteristics of MPs (shape, color, size, and type of polymers) were identified. This study found that MPs in commercial compost samples were found, reaching up to 160 particles/200 g of compost with various colors (blue, black, red, yellow, and white). The identified MPs had various sizes (0.1–1 mm) and shapes (81.8% fragment, 16.2% fiber, and 2% filament). The findings of this study are very important and significant to inform community and policymakers regarding the presence of MPs in commercial compost, hence, their intensive use in agriculture must be controlled and careful.
“A Marriage of Convenience” with UNESCO?
Authors: Hofstetter Rita , Schneuwly Bernard 
Published: January 2024

AbstractIn 1946, the foundation of UNESCO as a new international organisation acting in the field of education changed the context of the IBE’s activity fundamentally. Thanks to difficult negotiations—they began before UNESCO was set up thanks to the general secretary Marie Butts—the IBE succeeded in remaining autonomous. It became a specialised institution within UNESCO working exclusively on technical problems from a neutral point of view. It maintained its activities, with an enhanced legitimacy which also allowed it to increase the number of its member states and to approach its ideal of universality.
From the Institut Rousseau to the IBE: Promoting a New Era
Authors: Hofstetter Rita , Schneuwly Bernard 
Published: January 2024

AbstractChapters 8, 9 and 10 describe the positioning of the IBE from the point of view of the values it defended and the principles that guided it. This chapter examines how the IBE of the 1920s conveyed the spirit of education as being the primary tool for peace-building internationalism, being imbued with the Wilsonian pacifism that was embodied by Geneva once it was designated as the headquarters of the League of Nations. It also examines how the Bureau’s leaders succeeded or failed in reconciling these resolutely committed collective ideals with the strict objectivity and self-proclaimed neutrality of the IBE, the importance given to psychopedagogy as “Copernican revolution”, and the adjustments that such precarious balancing acts required. These analyses are enhanced in an insert on peace education as presented in the IBE’s bulletins.
“This is the real face of Covid-19!”: How Refused Knowledge Communities Entered the Pandemic Arena
Authors: Morsello Barbara , Neresini Federico , Agodi Maria Carmela 
Published: January 2024

AbstractThis chapter analyses the process involved in enacting broad discursive substantive arenas in the context of the Covid-19 pandemic. In so doing, the chapter highlights the role played by both human and non-human agents (such as the technologies mobilised to counteract the spread of SARS CoV-2 and the actors considered experts by refused knowledge communities’ [RKCs’] followers) in enacting counter narratives about the Covid-19 pandemic, so as to make sense of the global emergency according to a body of refused knowledge. Hence, the chapter illustrates how these counter narratives progressively empower RKCs to collaboratively act within a broad discursive arena, fostering public dissent against public health policies. Indeed, RKCs permeate public discourses about emerging societal issues in depth, also attracting the attention and concerns of both policymakers and media operators.
First shot of the smoking gun: probing the electroweak phase transition in the 2HDM with novel searches for A → ZH in $$ {\ell}^{+}{\ell}^{-}t\overline{t} $$ and $$ \nu \nu b\overline{b} $$ final states
Authors: Biekötter Thomas , Heinemeyer Sven , No Jose Miguel , Radchenko Kateryna , Olea Romacho María Olalla , Weiglein Georg 
Published: January 2024

Abstract
Recently the ATLAS collaboration has reported the first results of searches for heavy scalar resonances decaying into a Z boson and a lighter new scalar resonance, where the Z boson decays leptonically and the lighter scalar decays into a top-quark pair, giving rise to $$ {\ell}^{+}{\ell}^{-}t\overline{t} $$

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final states. This had previously been identified as a smoking-gun signature at the LHC for a first-order electroweak phase transition (FOEWPT) within the framework of two Higgs doublet models (2HDMs). In addition, ATLAS also presented new limits where the Z boson decays into pairs of neutrinos and the lighter scalar resonance into bottom-quark pairs, giving rise to the $$ \nu \nu b\overline{b} $$
ννb

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final state. We analyze the impact of these new searches on the 2HDM parameter space, with emphasis on their capability to probe currently allowed 2HDM regions featuring a strong FOEWPT. We also study the complementarity of these new searches with other LHC probes that could target the FOEWPT region of the 2HDM. Remarkably, the ATLAS search in the $$ {\ell}^{+}{\ell}^{-}t\overline{t} $$

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final state shows a local 2.85 σ excess (for masses of about 650 GeV and 450 GeV for the heavy and light resonance) in the 2HDM parameter region that would yield a FOEWPT in the early universe, which could constitute the first experimental hint of baryogenesis at the electroweak scale. We analyze the implications of this excess, and discuss the detectability prospects for the associated gravitational wave signal from the FOEWPT. Furthermore, we project the sensitivity reach of the $$ {\ell}^{+}{\ell}^{-}t\overline{t} $$

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signature for the upcoming runs of the LHC. Finally, we introduce the python package thdmTools, a state-of-art tool for the exploration of the 2HDM.
A New Regularized Siegel-Weil Type Formula. Part I
Authors: Ginzburg David , Soudry David 
Published: January 2024

AbstractIn this paper, we prove a formula, realizing certain residual Eisenstein series on symplectic groups as regularized kernel integrals. These Eisenstein series, as well as the kernel integrals, are attached to Speh representations. This forms an initial step to a new type of a regularized Siegel-Weil formula that we propose. This new formula bears the same relation to the generalized doubling integrals of Cai, Friedberg, Ginzburg and Kaplan, as does the regularized Siegel-Weil formula to the doubling integrals of Piatetski-Shapiro and Rallis.
A Motion-based Device Urinary Incontinence Treatment: A Longitudinal Analysis at 18 and 24 Months
Authors: Weinstein Milena M. , Dunivan Gena C. , Guaderrama Noelani M. , Richter Holly E. 
Published: January 2024

Abstract
Introduction and hypothesis
There are sparse data regarding the long-term efficacy of pelvic floor muscle training (PFMT) for the treatment of urinary incontinence (UI). The objective of this study was to evaluate the impact of an 8-week PFMT program guided by a motion-based intravaginal device versus a standard home program over 24 months.

Methods
Between October 2020 and March 2021, a total of 363 women with stress or stress-predominant mixed UI were randomized and completed an 8-week PFMT program using a motion-based intravaginal device (intervention group) or a home program following written/video instructions (control group). Participants were not asked to continue training after the 8-week program. At 18 and 24 months’ follow-up, the Urogenital Distress Inventory, short-form (UDI-6) and Patient Global Impression of Improvement (PGI-I) were collected. In the original trial, a total of 139 participants in each arm were needed to detect a 0.3 effect size (alpha = 0.05, power 0.8, one-tailed t test) in the difference in UDI-6 scores.

Results
A total of 231 participants returned 24-month data. Mean age at 24 months was 51.7 ± 14.5 years, and mean BMI was 31.8 ± 7.4 kg/m2. Mean change in UDI-6 scores from baseline to 24 months was greater in the intervention group than the control group (−21.1 ± 24.5 vs −14.8 ± 19.4, p = 0.04). Reported improvement using PGI-I was greater in the intervention group than in the control group at 24 months (35% vs 22%, p = 0.03, OR 1.95(95% CI 1.08, 3.57).

Conclusions
Pelvic floor muscle training guided by a motion-based prescription intravaginal device yielded durable and significantly greater UI symptom improvement than a standard home program, even in the absence of continued therapy.
Older adults are impaired in the release of grip force during a force tracking task
Authors: Davidson Sara , Learman Kenneth , Zimmerman Eric , Rosenfeldt Anson B. , Koop Mandy , Alberts Jay L. 
Published: January 2024

AbstractAge-related changes in force generation have been implicated in declines in older adult manual dexterity. While force generation is a critical aspect of the successful manipulation of objects, the controlled release of force represents the final component of dexterous activities. The impact of advancing age on the release of grip force has received relatively little investigation despite its importance in dexterity. The primary aim of this project was to determine the effects of age on the control of force release during a precision grip tracking task. Young adults (N = 10, 18–28 years) and older adults (N = 10, 57–77 years) completed a ramp-hold-release (0–35% of maximum grip force) force tracking task with their dominant hand. Compared to young adults, older adults were disproportionately less accurate (i.e., less time within target range) and had more error (i.e., greater relative root mean squared error) in the release of force, compared to generation of grip force. There was a significant difference between groups in two-point discrimination of the thumb, which was moderately correlated to force control across all phases of the task. The decline in force release performance associated with advanced age may be a result of sensory deficits and changes in central nervous system circuitry.
Metabolomic analysis of hydroxycinnamic acid inhibition on Saccharomyces cerevisiae
Authors: Ge Xiaoli , Chen Junxiao , Gu Jie , Yi Wenbo , Xu Shujie , Tan Liping , Liu Tongjun 
Published: January 2024

Abstract
Ferulic acid (FA) and p-coumaric acid (p-CA) are hydroxycinnamic acid inhibitors that are mainly produced during the pretreatment of lignocellulose. To date, the inhibitory mechanism of hydroxycinnamic acid compounds on Saccharomyces cerevisiae has not been fully elucidated. In this study, liquid chromatography-mass spectrometry (LC–MS) and scanning electron microscopy (SEM) were used to investigate the changes in S. cerevisiae cells treated with FA and p-CA. In this experiment, the control group was denoted as group CK, the FA-treated group was denoted as group F, and the p-CA-treated group was denoted as group P. One hundred different metabolites in group F and group CK and 92 different metabolites in group P and group CK were selected and introduced to metaboanalyst, respectively. A total of 38 metabolic pathways were enriched in S. cerevisiae under FA stress, and 27 metabolic pathways were enriched in S. cerevisiae under p-CA stress as identified through Kyoto Encyclopaedia of Genes and Genomes (KEGG) analysis. The differential metabolites involved included S-adenosine methionine, L-arginine, and cysteine, which were significantly downregulated, and acetyl-CoA, L-glutamic acid, and L-threonine, which were significantly upregulated. Analysis of differential metabolic pathways showed that the differentially expressed metabolites were mainly related to amino acid metabolism, nucleotide metabolism, fatty acid degradation, and the tricarboxylic acid cycle (TCA). Under the stress of FA and p-CA, the metabolism of some amino acids was blocked, which disturbed the redox balance in the cells and destroyed the synthesis of most proteins, which was the main reason for the inhibition of yeast cell growth. This study provided a strong scientific reference to improve the durability of S. cerevisiae against hydroxycinnamic acid inhibitors.

Key points
• Morphological changes of S. cerevisiae cells under inhibitors stress were observed.
• Changes of the metabolites in S. cerevisiae cells were explored by metabolomics.
• One of the inhibitory effects on yeast is due to changes in the metabolic network.
Venetoclax plus dose-adjusted R-EPOCH (VR-DA-EPOCH) or G-EPOCH bridging to subsequent cellular therapy for the patients with transformed lymphoma a single center clinical experience
Authors: Qin Shuchao , Jiang Rui , Dai Luomengjia , Miao Yi , Sha Yeqin , Qiu Tonglu , Ding Chongyang , Wang Zhen , Shi Chuanbing , Xia Yi , Fan Lei , Xu Wei , Li Jianyong , Zhu Huayuan 
Published: January 2024

AbstractIndolent lymphoma, including chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (FL), can undergo histological transformation into an aggressive subtype, typically diffuse large B-cell lymphoma (DLBCL). The prognosis of transformed lymphoma is poor. In this study, we reported the efficacy and toxicity of a combination of venetoclax, dose-adjusted rituximab or obinutuzumab, etoposide, prednisone, vincristine, doxorubicin, and cyclophosphamide (VR-DA-EPOCH or VG-DA-EPOCH) in 11 patients with biopsy-proven histology transformation into DLBCL, including 8 patients with RT and 3 with transformed FL (tFL). The study was conducted between October 2019 and March 2023 at our single center. The median age of participants at enrolment was 53 years. Six patients (85.7%, 6/7) achieved complete remission (CR) at the end of treatment. The best overall response rate (ORR) and CR rate were both 72.7%, respectively. Two patients received autologous hemopoietic stem cell transplant (ASCT) while two patients received ASCT concurrently with CAR-T therapy for consolidation. With a median follow-up of 13.5 (range, 2.4–29.8) months after enrollment, the median event-free survival, progression-free survival, and overall survival were 9.4, 11.5, and 17.5 months, respectively. Hematologic toxicities of grade ≥3 consisted of neutropenia (90.9%, 10/11), thrombocytopenia (63.6%, 7/11), and febrile neutropenia (54.5%, 6/11). In conclusion, VR-DA-EPOCH or VG-DA-EPOCH was a promising strategy to achieve an early remission, bridging to cellular therapy within this population.
Prognostic impact of peritoneal washing cytology in patients with biliary tract cancer
Authors: Sumiyoshi Tatsuaki , Uemura Kenichiro , Shintakuya Ryuta , Okada Kenjiro , Baba Kenta , Harada Takumi , Serikawa Masahiro , Ishii Yasutaka , Nakamura Shinya , Arihiro Koji , Murakami Yoshiaki , Takahashi Shinya 
Published: January 2024

AbstractPurposeTo elucidate the clinical significance of peritoneal washing cytology (PWC) in patients with resectable biliary tract cancer (BTC).MethodsClinical data of patients with BTC, who received PWC at curative intent surgery from March 2009 to December 2021, were retrospectively analyzed. Eligible patients were stratified into two groups according to positive or negative PWC. Recurrence-free survival and overall survival were compared between the two groups. Independent factors associated with positive PWC were investigated using multivariate analysis.ResultsAmong the 284 patients analyzed, all 53 patients with ampullary carcinoma showed negative PWC and these patients were excluded. Among the remaining eligible 231 patients, 41 patients had intrahepatic cholangiocarcinoma, 55 had gall bladder carcinoma, 72 had hilar cholangiocarcinoma, and 63 had distal cholangiocarcinoma. Eleven (4.8%) patients had positive PWC, and 220 (95.2%) had negative PWC. The median recurrence-free survival in the positive and negative PWC groups were 12.0vs.60.7 months (p = 0.005); the median overall survival times were 17.0vs.60.6 months (p = 0.008), respectively. Multivariate analysis revealed that serum carbohydrate antigen 19–9 level over 80 U/mL and multiple lymph node metastasis were independently associated with positive PWC (odds ratio [OR]: 5.84,p = 0.031; OR: 5.28,p = 0.021, respectively).ConclusionPatients with positive PWC exhibited earlier recurrence and shorter survival times compared with those with negative PWC.
The effect of resistin on the redox state of breast cancer cells
Authors: Pavlova Elitsa , Stojchevski Radoslav , Avtanski Dimiter 
Published: January 2024

Abstract
Purpose
Resistin is an inflammatory cytokine secreted mostly by adipocytes and immune cells that plays a role in the development of insulin resistance, diabetes, and cancer. We hypothesized that resistin’s inflammatory activity influences the free radical and oxidative stress pathways.

Methods
We used human breast carcinogenic (MCF-7 and MDA-MB-231) and non-carcinogenic (MCF-10A) cells in this investigation and correlated the absorbed resistin concentration with the change in oxidative stress (TBARS, carbonated proteins) and antioxidant activity (Antioxidant Capacity, SuperOxideDismutase, CATalase, Glutathione Peroxidase).

Results
Resistin was substantially more effective as a prooxidant at lower (12.5 ng/ml) concentrations, than at higher concentrations (25.0 ng/ml). Vitamin C did not appear to be an effective oxidative stress protector at antioxidant concentrations of 5.10–4 M. Leptin, at 100 ng/ml, did not result in conclusive oxidative stress or antioxidant defence stimulation, as expected.

Conclusion
Taken together, the findings support resistin’s role as a non-oxidative stress marker and a metabolic signaling molecule.