bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
Authors: Moraes Carolina Leão de , Mendonça Carolina Rodrigues , Melo Natália Cruz e , Tacon Fernanda Sardinha de Abreu , Junior Jair Pereira de Melo , Amaral Waldemar Naves do 
Published: November 2023

Abstract
Objective To investigate the clinicopathological significance and prognosis of the expression of the anterior gradient 3 (AGR3) protein in women with breast cancer.
Data Sources The PubMed, CINAHL, EMBASE, Scopus, and Web of Science databases were searched for studies published in English and without restrictions regarding the year of publication. The search terms were: breast cancer AND anterior gradient 3 OR AGR3 expression.
Study Selection We included observational or interventional studies, studies on AGR3 protein expression by immunohistochemistry, and studies on invasive breast cancer. Case reports, studies with animals, and reviews were excluded. In total, 4 studies were included, containing 713 cases of breast cancer.
Data Collection Data were extracted on clinicopathological characteristics and survival. A meta-analysis of the prevalence of AGR3 expression was performed according to the clinicopathological characteristics, hazard ratios (HRs), and overall survival and disease-free survival.
Data Synthesis The expression of AGR3 was found in 62% of the cases, and it was associated with histological grade II, positivity of estrogen and progesterone receptors, low expression of ki67, recurrence or distant metastasis, and lumen subtypes. In patients with low and intermediate histological grades, AGR3 expression was associated with worse overall survival (HR: 2.39; 95% confidence interval [95%CI]: 0.628–4.159; p = 0.008) and worse disease-free survival (HR: 3.856; 95%CI: 1.026–6.686; p = 0.008).
Conclusion The AGR3 protein may be a biomarker for the early detection of breast cancer and predict prognosis in luminal subtypes. In addition, in patients with low and intermediate histological grades, AGR3 protein expression may indicate an unfavorable prognosis in relation to survival.
Immobilization, Lymphedema, and Obesity are Predictive Factors in the Development of Adhesive Capsulitis in Breast Cancer Patients
Authors: Fernandes Marcos Rassi , Assis Flaviane Marques de , Spagnol Joana Ermida , Chaves Vinícius Barros 
Published: November 2023

Abstract
Objective Adhesive capsulitis is a condition characterized by shoulder pain and stiffness. Breast cancer treatment has been linked to the development of this condition, but its mechanisms are still little known. This study's objective was to identify predictors factors associated with the development of adhesive capsulitis in breast cancer patients.
Methods A case control study was performed with women undergoing treatment for breast cancer in a single center. The sampling was nonprobabilistic and consecutive. Adhesive capsulitis was defined as constant pain associated with decreased active and passive shoulder movement in anterior elevation, external rotation at 0°/90° abduction, and internal rotation at 90° abduction. The study group consisted of patients with shoulder pain and range of motion limitations, while the control group consisted of women without any shoulder abnormalities. Sociodemographic and clinical variables were collected. A univariate logistic regression was used to assess the influence of variables on the studied outcome. For p < 0.20, a multivariate logistic regression was used. The probability of null hypothesis rejection was 5%.
Results A total of 145 women were assessed, with 39 (26.9%) on the study group and 106 (73.1%) on the control group. The majority was under 60 years old. In the multivariate analysis, variables correlated to the outcome under study were shoulder immobilization (OR = 3.09; 95% CI: 1.33–7.18; p = 0.009), lymphedema (OR = 5.09; 95% CI: 1.81–14.35; p = 0.002), and obesity (OR = 3.91; 95% CI: 1.27–12.01; p = 0.017).
Conclusion Lymphedema, postsurgery immobilization, and obesity are predictive factors for the development of adhesive capsulitis in breast cancer patients.
Adaptation and Validation of the International Pelvic Pain Society's Quality of Life Questionnaire in Portuguese
Authors: Hayashi Letícia Ferracini Lenharo , Ribeiro Paulo Augusto Ayroza Galvão , Silva Júlio Cesar Rosa e , Brito Luiz Gustavo Oliveira , Ribeiro Helizabet Salomão Abdalla Ayroza 
Published: November 2023

Abstract
Objective In the present study, our aim was to translate, adapt, and validate the Pelvic Health History Form (a quality of life [QoL] questionnaire) of the International Pelvic Pain Society (IPPS) from English to Portuguese.
Methods The study was approved by the Ethics and Research Committee (CEP, in the Portuguese acronym) and the IPPS. The "Transcultural Adaptation" method comprised 5 stages: translation, synthesis, backtranslation, expert review, and pretest. Cultural adaptation and validation included cognitive interviews and statistical analysis of unanswered items (> 15%) in 14 clinic patients from CPP and endometriosis clinic at Santa Casa de São Paulo.
Results Strong equivalences were established between the USA and Brazil questionnaires in terms of semantics, idioms, experiences, and concepts. Eighteen culturally inappropriate items were identified and adjusted using the revised response rate index. The subjective form underwent rigorous assessments, confirming its accurate measurement of intended targets.
Conclusion The methodology showed efficiency and equivalence, confirming its validity. The user-friendly format and inclusion of translated, adapted, and validated instruments in Portuguese make the form valuable for evaluating pelvic health, with potential for future research.
Economic Analysis of Induction versus Elective Cesarean in Term Nulliparas with Supermorbid Obesity
Authors: Nehme Lea , Horgan Rebecca , Waller Jerri , Kumar Priyanka , Barake Carole , Huang Jim C. , Saade George , Kawakita Tetsuya 
Published: November 2023

Objective We sought to evaluate the economic benefit of the induction of labor compared with elective cesarean delivery in individuals with supermorbid obesity (body mass index 60 kg/m2 or greater) at term.
Study Design We developed an economic analysis model to compare induction of labor with elective cesarean delivery in nulliparous individuals with supermorbid obesity at term. The primary outcome was the total cost per strategy from a health system perspective with elective cesarean delivery as a reference group. Pregnancy outcomes for the index and subsequent pregnancies were considered. When available, probabilities of pregnancy outcomes were extracted from our institutions. Rare pregnancy outcomes, relative risks, and costs were derived from the literature. All costs in this analysis were inflated to 2022 USD (U.S. dollar). To determine the robustness of the decision model, we conducted one-way sensitivity analyses by changing point estimates of variables. We then performed a probabilistic sensitivity analysis using Monte Carlo simulation repeating 1,000 times to test the robustness of the results in the setting of simultaneous changes in probabilities, relative risks, and costs.
Results In the base-case analysis, assuming that 72.7% of nulliparous individuals undergoing induction of labor would have a cesarean delivery, induction of labor would cost $41,084 compared with $40,742 for elective cesarean delivery, resulting in a higher cost of $342 per nulliparous individuals with supermorbid obesity. In a sensitivity analysis, we found that induction of labor compared with elective cesarean is less economical if the probability of cesarean delivery after induction of labor exceeds 71%. Monte Carlo simulation suggests that elective cesarean delivery was the preferred cost-beneficial strategy with a frequency of 53.5%.
Conclusion: Among our patient population, induction of labor was less economical compared with elective cesarean delivery at term for nulliparous individuals with supermorbid obesity.
Key Points
When does word of mouth versus marketing drive brand performance most?
Authors: Bahadir S. Cem , Pauwels Koen 
Published: November 2023

AbstractEmerging markets present opportunities to brand managers who understand the drivers of word of mouth (WOM). What motivates consumers to share positive WOM (PWOM) about brands? Is it their perception of its product attributes, perception of its advertising, or the receipt of WOM from others? In this study, we explore the effects of received WOM (RWOM) and marketing mix and brand perception variables on the transmission of WOM for shampoo products in India and Thailand and contrast them with the mature market of Japan. Vector autoregressive models show that the impact of the studied variables on WOM transmission depends on brand performance stability and consumer involvement with the product category. The marketing mix has a greater impact on WOM transmission than RWOM across the countries for growing (vs. declining) brands. The impact of RWOM on the transmission of PWOM is greater for high- than low-involvement consumers. The difference in the impact of RWOM on the transmission of PWOM depends on the stability of brand performance. Managers should thus consider brand performance stability and consumer involvement versus the marketing mix when trying to stimulate WOM.
Human civilization dynamics: why we have different civilization patterns in history
Authors: Lu Peng , Zhang Zhuo , Onyebuchi Chiamaka Henrietta , Li Mengdi 
Published: November 2023

AbstractAfter the Axial Age, the West moved toward continuous disunity, but China had successfully maintained a persistent unity pattern. Conventional case (history event) studies are subject to selection bias and theoretical frameworks, which is not objective narrative. We use agent-based modeling (ABM) to reveal the historical dynamics of why civilizations take on distinct patterns (unity versus disunity). In China, the Qin Dynasty (initial unity) opened the Great Unity tradition in 221 BC. Before this, there was a major chaotic period (770 BC to 221 BC) with two periods. The first period, the Spring and Autumn (770 BC to 221 BC), opened this chaotic process and indirectly led to the initial unity. Then, the second period, the Warring States period (475 BC to 221 BC), directly led to this initial unity. This work models the second period and focuses on the question of why human civilizations take on different patterns in history. Finally, we have solved the conditions and boundaries of two patterns. Based on the second period, we have different conclusions. The bellicosity threshold is around 0.2 (for the previous period, this is 0.3), and the alliance propensity threshold is around 0.8 (for the previous period, this is 0.7). Moreover, the higher winner cost (beyond 5%) makes it impossible to achieve Unity. This work has one new contribution, such as solving social knowledge. We use BP neural networks to evaluate the knowledge graph to support history learning. It explains civilization patterns for humankind.
Exploring participatory communication implemented to improve the livelihood of rural Ethiopia
Authors: Gebeyehu Hailemesekel Zewedie , Jira Yohannes Shiferaw 
Published: November 2023

AbstractThe study aimed to explore how participatory communication can be used as an instrument for interventions enhancing agricultural production to improve the livelihoods of rural people. Specifically, it was designed to explore the nature of participatory approaches in the Ethiopian agricultural sector. The top-down approach that prevailed in the past lost its faith, and consequently, stakeholders practiced a participatory communication approach. Thus, explorative qualitative research was applied through focus group discussions and in-depth interviews to collect data. Data were transcribed, documented, coded, and thematically analyzed based on recurring themes. The findings show that if properly implemented, development agents and agricultural experts believe that participatory communication is instrumental in mobilizing the community. However, the routine does not allow development agents and experts to use the participatory approach. Besides, farmers are not given sufficient time due to insufficient interaction and communication on agricultural issues. Farmers and development agents have no ongoing, programmed, and frequent contact. The communication between development agents and higher-level agricultural experts is mainly top-down. Provincial and regional experts do not regularly visit and observe farm sites; they depend on the monthly paper report to execute modifications to the annual plan. There is no practical obligation with the consensus that demands farmers, development agents, and experts accomplish their tasks and duties on time with maximum effort. No dialogical session is available for the community to discuss their matters. Therefore, we suggest stakeholders use a multilevel and inclusive intervention in rural agriculture.
The mediating effects of entrepreneurial self-efficacy in the relationship between entrepreneurship education and start-up readiness
Authors: Adeniyi Adeshina Olushola 
Published: November 2023

AbstractsIn Nigeria, there is a growing concern that graduates from science and engineering fields are not ready for entrepreneurship due to low business creation among young individuals. Another perspective suggests that entrepreneurship curriculum only prepares the students to seek for employment rather than become entrepreneurs. Previous studies have revealed that there are several cognitive factors responsible for readiness to start a business other than entrepreneurship education. The purpose of this study is to determine social cognitive factors that can stimulate start-up readiness. Thus, this study examined the mediating effects of entrepreneurial self-efficacy (ESE) in the relationship between entrepreneurship education and start-up readiness. Three dimensions of entrepreneurship education and four dimensions of ESE were examined as determinants of start-up readiness using survey research approach. Data from 289 exit-level students from three Technical Vocational Education and Technology (TVET) colleges were analysed using SPSS 25 and Smart PLS 4 software. Entrepreneurship education (in terms of technical skills and business management skills) shows partial support for ESE (in terms of searching, planning, and implementing). However, entrepreneurship education (in terms of personal skills) only shows support for ESE (in terms of marshalling). The results of the mediation analysis suggest that ESE (in terms of searching, planning, and implementing) partially mediates the relationship between entrepreneurship education and start-up readiness, while ESE marshalling failed to mediate the relationship between entrepreneurship education and start-up readiness. This study also revealed that apart from ESE marshalling, all components of ESE have a direct and significant relationship with start-up readiness. Another contribution of this study indicates that personal entrepreneurial skills are required antecedent for enhancing business resources gathering skills towards start-up readiness among young individuals in Nigeria. The study suggests fostering entrepreneurial mindset via simulation-based techniques, role playing, and mentoring with practical translations.
Lifestyle pattern analysis unveils recovery trajectories of communities impacted by disasters
Authors: Coleman Natalie , Liu Chenyue , Zhao Yiqing , Mostafavi Ali 
Published: November 2023

AbstractLifestyle recovery captures the collective effects of population activities as well as the restoration of infrastructure and business services. This study uses a novel approach to leverage privacy-enhanced location intelligence data, which is anonymized and aggregated, to characterize distinctive lifestyle patterns and to unveil recovery trajectories after 2017 Hurricane Harvey in Harris County, Texas (USA). The analysis integrates multiple data sources to record the number of visits from home census block groups (CBGs) to different points of interest (POIs) in the county during the baseline and disaster periods. For the methodology, the research utilizes unsupervised machine learning and ANOVA statistical testing to characterize the recovery of lifestyles using privacy-enhanced location intelligence data. First, primary clustering using k-means characterized four distinct essential and non-essential lifestyle patterns. For each primary lifestyle cluster, the secondary clustering characterized the impact of the hurricane into four possible recovery trajectories based on the severity of maximum disruption and duration of recovery. The findings further reveal multiple recovery trajectories and durations within each lifestyle cluster, which imply differential recovery rates among similar lifestyles and different demographic groups. The impact of flooding on lifestyle recovery extends beyond the flooded regions, as 59% of CBGs with extreme recovery durations did not have at least 1% of direct flooding impacts. The findings offer a twofold theoretical significance: (1) lifestyle recovery is a critical milestone that needs to be examined, quantified, and monitored in the aftermath of disasters; (2) spatial structures of cities formed by human mobility and distribution of facilities extend the spatial reach of flood impacts on population lifestyles. These provide novel data-driven insights for public officials and emergency managers to examine, measure, and monitor a critical milestone in community recovery trajectory based on the return of lifestyles to normalcy.
Systemic thinking and gender: an exploratory study of Mexican female university students
Authors: Cruz-Sandoval Marco , Carlos-Arroyo Martina , de los Rios-Berjillos Araceli , Vázquez-Parra José Carlos 
Published: November 2023

AbstractThe purpose of this article is to present the results of a study conducted on a population of students from two educational institutions in western Mexico. The intention is to identify how students perceive their level of systemic thinking, focusing primarily on women. Thus, this article seeks to identify differences not only on the basis of gender (men–women) but also on the basis of social status (public and private institutions). Methodologically, a descriptive statistical analysis was carried out with which it was possible to conclude that, although statistically significant differences between men and women are not identified, they are found between groups of women in public and private institutions. This article invites reflection on the need to study possible gender gaps from an intersectional perspective, which considers the differences between genders and the various dimensions and relations of women in their educational process.
Finiteness of quantum gravity with matter on a PL spacetime
Authors: Miković A 
Published: November 2023

Abstract
We study the convergence of the path integral (PI) for general relativity with matter on a picewise linear (PL) spacetime that corresponds to a triangulation of a smooth manifold by using a PI measure that renders the pure gravity PI finite. This measure depends on a parameter p, and in the case when the matter content is just scalar fields, we show that the PI is absolutely convergent for

p
>

0,5 and not more than two scalar fields. In the case of Yang–Mills (YM) fields, we show that the PI is absolutely convergent for the U(1) group and

p
>

0,5. In the case of Dirac fermions, we show that the PI is absolutely convergent for any number of fermions and a sufficiently large p. When the matter content is given by scalars, YM fields and fermions, as in the case of the standard model (SM), we show that the PI is absolutely convergent for

p
>

52,5. Hence one can construct a finite quantum gravity theory on a PL spacetime such that the classical limit is general relativity coupled to the SM.
Helicon waves in a converging-diverging magnetoplasma
Authors: Filleul F , Caldarelli A , Takahashi K , Boswell R W , Charles C , Cater J E , Rattenbury N 
Published: November 2023

Abstract
Waves propagating along a converging-diverging rf magnetoplasma having the characteristics of a bounded m = 0 helicon mode are reported and characterised. The discharge features a 30

cm separation between the region of radiofrequency energy deposition by a single loop antenna and the region of maximum magnetic field applied by a pair of coils. With 200

W of rf input power, up to a five-fold increase in axial plasma density between the antenna and the magnetic mirror throat is observed together with an Ar II blue-mode. Two dimensional B-dot probe measurements show that the rf magnetic fields are closely guided by the converging-diverging geometry. The wave is characterised as a m = 0 mode satisfying the helicon dispersion relation on-axis with radial boundary conditions approximately matching the radii of the plasma column. Analysis of the wave phase velocity and wave axial damping failed to identify collisionless or collisional wave-plasma coupling mechanisms. Instead, the wave axial amplitude variations can be explained by local wave resonances and possible reflections from localised rapid changes of the refractive index. A Venturi-like effect owing to the funnel-shaped magnetoplasma and conservation of the wave energy may also explain some level of amplitude variations.
Advancing the pressure sensing performance and biocompatible of conductive rGO/PEDOT/PDMS composite film for simple and efficient pressure sensor
Authors: Peng Zhongquan , Zhu Changhong , Zhang Xiaodong , Zhang Linlin 
Published: November 2023

Abstract
Recently, the demand for superior wearable strain sensors has been growing steadily with the widespread application of stretchable electronics. Based on polydimethylsiloxane (PDMS) and poly(3,4-ethylenedioxythiophene) (PEDOT):polystyrene sulfonate, it has good compatibility with graphene doping. Herein, an uncomplicated and capable pressure sensor based on PEDOT/PDMS-wrapped free-standing reduced graphene oxide (rGO) was devised and manufactured. The graphene-containing composite conductor exhibits superb electrical conductivity, resilience, and piezoresistive effect, and surprisingly exhibits excellent antibacterial capabilities and cycling constancy. The fast response and recovery times of this pressure sensor are below 9 and 21 ms, respectively. The magnitude of current changes did not fluctuate significantly after 10 000 cycles of use, which indicates the great dependence of the sensor. Strain sensors as one of primary demand is that composite conductors are attached straight to the mortal skin (joints, elbows and knees) for actual-time monitoring.