bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child‐focused infant and early childhood mental health consultation: Shifting adult attributions to reduce the risk for preschool expulsion
Authors: Newland Rebecca , Silver Rebecca B. , Herman Rachel , Hartz Karyn , Coyne Alice , Seifer Ronald 
Published: January 2024

AbstractInfant and early childhood mental health consultation (IECMHC) in early care and education (ECE) settings is a promising approach to support young children. Although research on the effects of IECMHC is encouraging, it is limited by the complexities of the systems in which IECMHC is implemented and the variability in IECMHC models. The current study aims to clearly articulate a statewide, child‐focused, short‐term IECMHC model, assess consultee satisfaction, examine the effects of consultation on children's functioning in the school and home settings, and evaluate changes in teacher perceptions associated with expulsion risk following consultation. In total, 268 children ages 1–5 (69% White, 75% male) and their family and school caregivers participated in consultation in a New England state, and 95 children and caregivers were included in an evaluation subsample. Of this subsample, teachers and ECE administrators, but not families, indicated significant improvement in children's functioning from referral to end of consultation. There was also a significant decrease in children's risk of expulsion, as measured by teachers’ perceptions associated with expulsion decisions. This study contributes to the IECMHC literature by providing results specific to a child‐focused model of consultation and highlighting the possible role of adult attributions for children in ECE.
Chemical, electrochemical, and surface studies of Rosa damascene extract as a green corrosion inhibitor for carbon steel in sulfuric acid environment
Authors: Elabbasy Hanaa M. , Elnagar Mohamed E. , Fouda Abd El‐Aziz S. 
Published: January 2024

AbstractTo develop an environmentally acceptable corrosion inhibitor Rosa damascene extract (RD) served as the main ingredient in H2SO4 pickling processes. X‐ray photoelectron spectroscopy (XPS), Fourier‐transform infrared spectroscopy (FT‐IR), technique of electrochemical impedance spectroscopy (EIS), polarization (PP) curves, and tests of weight loss (WL) have all been utilized to examine the inhibitory behavior of Rosa damascene on C‐steel corrosion in 1 M H2SO4 environment. The results show that the extract effectively inhibited the Zn′ corrosion in 1 M H2SO4. The inhibition was more effective at higher concentrations and temperatures. The inhibitory efficiency increased to 93.5% at a higher applied temperature (45°C) and higher Rosa damascene concentration (300 ppm). However, utilizing the weight loss method at potassium iodide addition, the inhibitory effectiveness of 300 ppm of Rosa damascene was synergistically increased from 75.0% to 96.1% at 25°C. Temkin isotherm was congruent with the adsorption process that produced the inhibitory impact on the C‐steel. The chemical adhesion of the Rosa damascene extract to the surface of the C‐steel was determined by the free energy of adsorption (ΔGoads = 40.5 kJ/mol.). In H2SO4 solution, corrosion of C‐steel may be prevented by the powerful inhibitor Rosa damascene extract.
Atomic force microscopy of spherical intermediates on the pathway to fibril formation of influenza A virus nuclear export protein
Authors: Koroleva Olga N. , Kuzmina Natalia V. , Dubrovin Evgeniy V. , Drutsa Valeriy L. 
Published: January 2024

AbstractThe nuclear export protein of the influenza A virus (NEP) is involved in many important processes of the virus life cycle. This makes it an attractive target for the treatment of a disease caused by a virus. Previously it has been shown, that recombinant variants of NEP are highly prone to aggregation in solution under various conditions with the formation of amyloid‐like aggregates. In the present work, the amyloid nature of NEP aggregates was evidenced by Congo red binding assays. Atomic force microscopy has shown that NEP can form two types of spherical nanoparticles, which provide an alternative pathway for the formation of amyloid‐like fibrils. Type I of these “fibrillogenic” spheres, formed under physiological conditions, represents the micelle‐like particles with height 10–60 nm, which can generate worm‐like flexible fibrils with the diameter 2.5–4.0 nm, length 20–500 nm and the Young's modulus ~73 MPa. Type II spherical aggregates with size of about 400–1000 nm, formed at elevated temperatures, includes fractions of drop‐like and vesicle‐like particles, generating more rigid amyloid‐like fibrils with height of ~8 nm, and length of up to 2 μm. The hypothetical mechanism of fibril formation via nanospherical structures was suggested.Research Highlights
AFM has revealed two types of the influenza A virus nuclear export protein spherical aggregates.
They provide an alternative pathway for the formation of amyloid‐like fibrils.
The mechanism of fibril formation via spherical structures is suggested.
Single‐cell RNA sequencing reveals the mechanism of PI3K/AKT/mTOR signaling pathway activation in lung adenocarcinoma by KRAS mutation
Authors: Xu Long , Ding Renquan , Song Shuxi , Liu Junling , Li Jingyu , Ju Xing , Ju Baozhao 
Published: January 2024

AbstractBackgroundAberrant activation of the phosphatidlinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway has been shown to play an important role in lung adenocarcinoma (LUAD). The effect of KRAS mutations, one of the important signatures of LUAD, on the PI3K/AKT/mTOR pathway in LUAD remains unclear.MethodsThe Seurat package and principal component analysis were used for cell categorization of single‐cell RNA sequencing data of LUAD. The AUCell score was used to assess the activity of the PI3K/AKT/mTOR pathway. Meanwhile, using the gene expression profiles and mutation profiles in the The Cancer Genome Atlas dataset, LUAD patients were categorized into KRAS‐mutant (KRAS‐MT) and KRAS‐wild‐types (KRAS‐WT), and the corresponding enrichment scores were calculated using gene set enrichment analysis analysis. Finally, the subpopulation of cells with the highest pathway activity was identified, the copy number variation profile of this subpopulation was inscribed using the inferCNV package and the CMap database was utilized to make predictions for drugs targeting this subpopulation.ResultsThere is higher PI3K/AKT/mTOR pathway activity in LUAD epithelial cells with KRAS mutations, and high expression of KRAS, PIK3CA, AKT1 and PDPK1. In particular, we found significantly higher levels of pathway activity and associated gene expression in KRAS‐MT than in KRAS‐WT. We identified the highest pathway activity on a subpopulation of GRB2+ epithelial cells and the presence of amplified genes within its pathway. Finally, drugs were able to target GRB2+ epithelial cell subpopulations, such as wortmannin, palbociclib and angiogenesis inhibitor.ConclusionsThe present study provides a basic theory for the activation of the PI3K/AKT/mTOR signaling pathway as a result of KRAS mutations.
[3 + 2] Cycloaddition of nitrile oxides to dichloropropenes and 1,3‐dichlorobut‐2‐ene: A regioselectivity issue
Authors: Shilova Alexandra N. , Shatokhina Nina S. , Kondrashov Evgeniy V. 
Published: January 2024

AbstractThe reaction of nitrile oxides with 2,3‐dichloroprop‐1‐ene, 1,3‐dichloroprop‐1‐ene, and 1,3‐dichlorobut‐2‐ene leads to 5‐(chloromethyl)isoxazoles, 4‐(chloromethyl)isoxazoles, or to mixtures of both regioisomers. The direction of cycloaddition and reactivity of substrate is determined by the steric hindrance at the terminal carbon atom of the alkene double bond. It has been found that the isomeric products of cycloaddition of nitrile oxides to 1,3‐dichloropropene have significantly different dehydrochlorination capabilities. The experimental data on the regioselectivity of cycloaddition and the relative reactivity of substrates are in agreement with the results of quantum chemical calculations.
Associations of Intracranial Artery Length and Branch Number on Time‐of‐Flight MRA With Cognitive Impairment in Hypertensive Older Males
Authors: Chen Zhensen , Liu Wenjin , Balu Niranjan , Chen Li , Ortega Dakota , Huang Xiaoqin , Hatsukami Thomas S. , Yang Junwei , Yuan Chun 
Published: January 2024

BackgroundHypertension‐induced impairment of the cerebral artery network contributes to cognitive impairment. Characterizing the structure and function of cerebral arteries may facilitate the understanding of hypertension‐related pathological mechanisms and lead to the development of new indicators for cognitive impairment.PurposeTo investigate the associations between morphological features of the intracranial arteries distal to the circle of Willis on time‐of‐flight MRA (TOF‐MRA) and cognitive performance in a hypertensive cohort.Study TypeProspective observational study.Population189 hypertensive older males (mean age 64.9 ± 7.2 years).Field Strength/SequenceTOF‐MRA sequence with a 3D spoiled gradient echo readout and arterial spin labeling perfusion imaging sequence with a 3D stack‐of‐spirals fast spin echo readout at 3T.AssessmentThe intracranial arteries were segmented from TOF‐MRA and the total length of distal arteries (TLoDA) and number of arterial branches (NoB) were calculated. The mean gray matter cerebral blood flow (GM‐CBF) was extracted from arterial spin labeling perfusion imaging. The cognitive level was assessed with short‐term and long‐term delay‐recall auditory verbal learning test (AVLT) scores, and with montreal cognitive assessment.Statistical TestsUnivariable and multivariable linear regression were used to analyze the associations between TLoDA, NoB, GM‐CBF and the cognitive assessment scores, with P < 0.05 indicating significance.ResultsTLoDA (r = 0.314) and NoB (r = 0.346) were significantly correlated with GM‐CBF. Multivariable linear regression analyses showed that TLoDA and NoB, but not GM‐CBF (P = 0.272 and 0.141), were significantly associated with short‐term and long‐term delay‐recall AVLT scores. These associations remained significant after adjusting for GM‐CBF.Data ConclusionThe TLoDA and NoB of distal intracranial arteries on TOF‐MRA are significantly associated with cognitive impairment in hypertensive subjects.Level of Evidence2Technical EfficacyStage 3
A flexible energy management for distributed energy supplied smart home in microgrid connection with grid‐connection/islanding mode functionality
Authors: Büyük Mehmet 
Published: January 2024

AbstractIn this study, a flexible control approach is presented for smart home with DES system in microgrid connection. The smart home with DES has operation capability under GC‐Mode and I‐Mode functions with the proposed control algorithm. The control algorithm is also developed in terms of international standards IEEE 929 and IEC 61727 for grid connection requirements. Additionally, a PLL‐less control algorithm is embedded in the proposed control algorithm for the active/reactive power management and the grid synchronization. Thus, slow dynamic response and calculation burden issues in controller is avoided and the power flow capability of the grid‐connected DES in smart home is enhanced. Furthermore, the coordinate transformation is fulfilled for the power flow control in the control loop via the generation of cosine and sinus functions. Besides, the mathematical formulations of the proposed control algorithm are presented in detail. To show the effectiveness of the proposed control algorithm, a smart home with a photovoltaic DES model is designed and constructed in a simulation environment. The proposed control method is tested under various operation cases such as dynamic environmental conditions, GC‐Mode/I‐Mode, reactive power support and voltage variations. The proposed method shows efficient performance under applications of the different operation situations. Moreover, the international requirements are satisfied for GC‐Mode and I‐Mode transitions.
Rethinking trauma‐related psychopathology in the Hierarchical Taxonomy of Psychopathology (HiTOP)
Authors: Levin‐Aspenson Holly F. , Greene Ashley L. 
Published: January 2024

AbstractResearch on trauma exposure and its consequences has made tremendous progress in elucidating the role of traumatic life events in the development and maintenance of psychopathology as well as in evaluating interventions aimed at addressing the personal and public burden of trauma‐related psychopathology. However, there is growing concern that problems with predominant definitions of posttraumatic syndrome (e.g., content coverage and scope, within‐category heterogeneity, excessive diagnostic comorbidity) limit further efforts to fully conceptualize trauma‐related psychopathology and deliver appropriate, personalized interventions. As demonstrated by an impressive body of research over the past several years, the Hierarchical Taxonomy of Psychopathology (HiTOP) presents a compelling alternative to traditional nosologies in terms of empirically based characterizations of psychopathology phenotypes, with evidence of strong utility for research and clinical applications. However, HiTOP's primary focus on descriptive psychopathology has resulted in an unacceptable gap regarding the conceptualization of trauma‐related psychopathology from a dimensional, transdiagnostic perspective. We see an important opportunity to clarify what HiTOP can offer the field of traumatic stress research and articulate a future for trauma‐related psychopathology within HiTOP. We argue for disaggregating psychopathology symptoms from their purported causes and, instead, developing a detailed taxonomy of traumatic events alongside an ever‐evolving HiTOP model. Doing so will help identify empirically based phenotypes of trauma‐related psychopathology that (a) go beyond the traditional PTSD criterion sets and (b) allow for the possibility that different features of traumatic experiences (e.g., type, duration, subjective meaning) may be associated with different symptom sequelae across different psychopathology spectra.
A Multiplanar Radiomics Model Based on Cranial Ultrasound to Predict the White Matter Injury in Premature Infants and an Analysis of its Correlation With Neurodevelopment
Authors: Zhu Ting , Zhang Shuang , Jiang Wei , Chai Dan , Mao Jiaoyu , Wei Yuya , Xiong Jiayu 
Published: January 2024

ObjectivesTo develop and evaluate a multiplanar radiomics model based on cranial ultrasound (CUS) to predict white matter injury (WMI) in premature infants and explore its correlation with neurodevelopment.MethodsWe retrospectively reviewed 267 premature infants. The radiomics features were extracted from five standard sections of CUS. The Spearman's correlation coefficient combined with the least absolute shrinkage and selection operator (LASSO) was applied to select features and build radiomics signature, and a multiplanar radiomics model was constructed based on the radiomics signature of five planes. The performance of the model was evaluated using the area under the receiver operating characteristic curve (AUC). Infants with WMI were re‐examined by ultrasound at 2 and 4 weeks after birth, and the recovery degree of WMI was evaluated using multiplanar radiomics. The relationship between WMI and the recovery degree and neurodevelopment was analyzed.ResultsThe AUC of the multiplanar radiomics in the training and validation sets were 0.94 and 0.91, respectively. The neurodevelopmental function scores in infants with WMI were significantly lower than those in healthy preterm infants and full‐term newborns (P < .001). There were statistically significant differences in the neurodevelopmental function scores of infants between the 2‐ and 4‐week lesion disappearance and 4‐week lesion persistence (P < .001).ConclusionsThe multiplanar radiomics model showed a good performance in predicting the WMI of premature infants. It can not only provide objective and accurate results but also dynamically monitor the degree of recovery of WMI to predict the prognosis of premature infants.
Thermodynamic properties calculations of Cu‐based species
Authors: Yousuf Muhammad , Arshad Muhammad Fahad , Tian Zhen‐Yu 
Published: January 2024

AbstractThis work focuses on the thermodynamic property calculations of seven copper‐based species, namely copper, copper oxide, copper hydroxide, copper nitrate, and copper hydroxide nitrate. The structures of these species were optimized to achieve stable geometries. The density functional theory (DFT) calculations were employed to obtain various thermodynamic properties such as entropy, enthalpy, Gibbs free energy, and heat capacity at constant pressure. A comparative investigation was performed on the temperature‐dependent behavior of key thermodynamic parameters. Species characterized by a higher quantity of atoms tend to demonstrate elevated thermodynamic properties. Copper and copper hydroxide nitrate had higher thermodynamic values than their oxides and other counterparts. It should be noted that the thermodynamic properties of copper hydroxide nitrate were newly computed, and the results showed that the thermodynamic values of the compound structure were higher than their crystalline counterparts. Moreover, due to the large structure size and solid phase, these thermodynamic values exhibited discrepancies with previously calculated computational and experimental values. The thermodynamic property values that depended on temperature were transformed into NASA 7‐Coefficient polynomials parameterization. The newly determined thermodynamic data and polynomials provide valuable insights into the thermodynamic behavior of copper‐based species. It will help better understand their surface sites and different crystalline structures. Such data can be used to better understand a variety of industrial processes, including combustion, gasification, chemical synthesis, and further to enhance efficiency, reduce costs, and minimize hazardous environmental emissions.
Tibial tuberosity‐trochlear groove distance is significantly decreased by medial closing wedge distal femoral osteotomy
Authors: Watrinet Julius , Joergens Maximilian , Blum Philipp , Ehmann Yannick , Augat Peter , Stuby Fabian , Schröter Steffen , Harrer Joerg , Fürmetz Julian 
Published: January 2024

AbstractPurposeWhile medial closing wedge distal femoral osteotomy (MCWDFO) has been used to address patella instability combined with valgus malalignment, its impact on patellofemoral parameters remains uncharted. Hence, this study seeks to establish a three‐dimensional (3D) planning of MCWDFO and measure its effect on the tibial tubercle ‐ trochlear groove distance (TTTG) through simulation and calculation.MethodsMCWDFO with a stepwise increment of one‐degree varisation (1°–15°) was performed on 3D surface models of 14 lower extremities with valgus malalignment and 24 lower extremities with neutral alignment of the lower limb, resulting in a total of 608 simulations. Anatomic landmarks were employed to measure hip‐knee‐ankle angle (HKA), TTTG, and femoral torsion for each simulation. A mathematical formula was adopted to calculate TTTG changes following MCWDFO, and subsequently the mean simulated and calculated TTTG values were compared. Following a standardised protocol, MCWDFO was performed without rotational changes.ResultsMCWDFO exhibited an almost linear reduction in TTTG, at a rate of approximately −1.05 ± 0.13 mm per 1° of varisation, demonstrating a strong negative correlation (R = −0.83; p < 0.001). Limb alignment did not exert an influence on TTTG change; however, it correlated with tibial plateau width. The mean difference between the simulated and calculated TTTG values amounted to 0.03 ± 0.03 mm per 1° varisation (p < 0.001).ConclusionThe TTTG distance is linearly reduced by 1.05 mm for every 1° of varisation within the varus correction range of 0°–15° during MCWDFO. Patients with combined valgus and patellar instability may benefit from MCWDFO due to frequently pathological TTTG.Level of EvidenceLevel III, descriptive laboratory study.
Inhaled fosamprenavir for laryngopharyngeal reflux: Toxicology and fluid dynamics modeling
Authors: Lesnick Alexandra , Samuels Tina L. , Seabloom Donna , Wuertz Beverly , Ojha Abhilash , Seelig Davis , Ondrey Frank , Wiedmann Timothy S. , Hogan Chris , Torii Emma , Ouyang Hui , Yan Ke , Garcia Guilherme J. M. , Bock Jonathan M. , Johnston Nikki 
Published: January 2024

AbstractObjectivesApproximately 25% of Americans suffer from laryngopharyngeal reflux (LPR), a disease for which no effective medical therapy exists. Pepsin is a predominant source of damage during LPR and a key therapeutic target. Fosamprenavir (FOS) inhibits pepsin and prevents damage in an LPR mouse model. Inhaled FOS protects at a lower dose than oral; however, the safety of inhaled FOS is unknown and there are no inhalers for laryngopharyngeal delivery. A pre‐Good Lab Practice (GLP) study of inhaled FOS was performed to assess safety and computational fluid dynamics (CFD) modeling used to predict the optimal particle size for a laryngopharyngeal dry powder inhaler (DPI).MethodsAerosolized FOS, amprenavir (APR), or air (control) were provided 5 days/week for 4 weeks (n = 6) in an LPR mouse model. Organs (nasal cavity, larynx, esophagus, trachea, lung, liver, heart, and kidney) were assessed by a pathologist and bronchoalveolar lavage cytokines and plasma cardiotoxicity markers were assessed by Luminex assay. CFD simulations were conducted in a model of a healthy 49‐year‐old female.ResultsNo significant increase was observed in histologic lesions, cytokines, or cardiotoxicity markers in FOS or APR groups relative to the control. CFD predicted that laryngopharyngeal deposition was maximized with aerodynamic diameters of 8.1–11.5 μm for inhalation rates of 30–60 L/min.ConclusionsA 4‐week pre‐GLP study supports the safety of inhaled FOS. A formal GLP assessment is underway to support a phase I clinical trial of an FOS DPI for LPR.Level of EvidenceNA.
Metalens in Improving Imaging Quality: Advancements, Challenges, and Prospects for Future Display
Authors: Peng Yuyan , Zhang Jiawei , Zhou Xiongtu , Chen Chunliang , Guo Tailiang , Yan Qun , Zhang Yongai , Wu Chaoxing 
Published: January 2024

AbstractMetalens, a metasurface with a focusing phase, has been the focus of research due to its immense potential for use in imaging and display technology. Traditional lens and optical imaging systems rely on phase accumulation, however metalens with subwavelength structures provide a disruptive path for miniaturized optical imaging systems by allowing unfettered modulation of incident light's phase and amplitude. Recently, extensive efforts have been devoted to exploring new design strategies, new functionalities, and possible applications. This paper reviews the development, principle, classification, and research status of metalens. In particular, this review focuses on the progress and challenges of improving imaging quality and expanding imaging diversity, including improvements of resolution, enhancement of depth of field, extension of field of view, and achromatism. Lastly, the prospects of metalens in the future display are summarized, and the application potentials of metalens in novel 3D display, intelligent and bionic display, as well as nano‐pixelate light‐emitting display (NLED) are emphasized.