bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of family members of cancer patients in palliative care: a qualitative systematic review protocol
Authors: Maia Flávia de Oliveira Motta , Guimarães Lívia Carneiro , Misko Maira Deguer , de Souza Thainara Rocha , Fonseca Marileise Roberta Antoneli 
Published: November 2023

Objective:
The objective of this review is to synthesize the experiences of family members of cancer patients in palliative care.

Introduction:
Increasingly, palliative care is the approach advocated when a life-threatening illness has been diagnosed. Cancer patients and their families, when receiving early identification, correct assessment, and treatment of pain and other problems through palliative care, report feeling supported in their illness experience. The patients and their families also describe immediate and personalized symptom management, holistic support, decision-making guidance, and preparation for the future, including the dying process and grief stages. A growing number of studies address palliative care patients and, in particular, the central role of family in this approach. This review will synthesize qualitative research on this subject, providing recommendations to health professionals to help them better understand the experiences and needs of family members of cancer patients receiving palliative care.

Inclusion criteria:
The review will consider studies examining experiences of families of cancer patients in palliative care, in all types of settings and contexts. The studies will focus on qualitative data, including, but not limited to, designs such as phenomenology, grounded theory, ethnography, action research, qualitative descriptive, and mixed methods studies.

Methods:
The review will follow the JBI methodology for systematic reviews of qualitative evidence. The search strategy will aim to locate both published and unpublished studies, in any language, with no date restrictions. Methodological quality will be evaluated using the standard JBI critical appraisal checklist for qualitative research. The findings will be pooled using the meta-aggregation approach or will be presented in narrative format. The final synthesized findings will be graded according to the ConQual approach.

Systematic review registration number:
PROSPERO CRD42022333937
Evolution of 1500-m Olympic Running Performance
Authors: Foster Carl , Hanley Brian , Barroso Renato , Boullosa Daniel , Casado Arturo , Haugen Thomas , Hettinga Florentina J. , Jones Andrew M. , Renfree Andrew , Skiba Philip , St Clair Gibson Alan , Thiel Christian , de Koning Jos J. 
Published: November 2023

Purpose: This study determined the evolution of performance and pacing for each winner of the men’s Olympic 1500-m running track final from 1924 to 2020. Methods: Data were obtained from publicly available sources. When official splits were unavailable, times from sources such as YouTube were included and interpolated from video records. Final times, lap splits, and position in the peloton were included. The data are presented relative to 0 to 400 m, 400 to 800 m, 800 to 1200 m, and 1200 to 1500 m. Critical speed and D′ were calculated using athletes’ season’s best times. Results: Performance improved ∼25 seconds from 1924 to 2020, with most improvement (∼19 s) occurring in the first 10 finals. However, only 2 performances were world records, and only one runner won the event twice. Pacing evolved from a fast start–slow middle–fast finish pattern (reverse J-shaped) to a slower start with steady acceleration in the second half (J-shaped). The coefficient of variation for lap speeds ranged from 1.4% to 15.3%, consistent with a highly tactical pacing pattern. With few exceptions, the eventual winners were near the front throughout, although rarely in the leading position. There is evidence of a general increase in both critical speed and D′ that parallels performance. Conclusions: An evolution in the pacing pattern occurred across several “eras” in the history of Olympic 1500-m racing, consistent with better trained athletes and improved technology. There has been a consistent tactical approach of following opponents until the latter stages, and athletes should develop tactical flexibility, related to their critical speed and D′, in planning prerace strategy.
Twice Invisible, Twice Clandestine. Football and Lesbianism in Spain During the Years of Democratic Transition (1970–1982)
Authors: Ribalta Alcalde Dolors , Pujadas Xavier 
Published: November 2023

The main objective of this paper is to analyze the relationship between women’s football and lesbianism during the 1970s in Spain as well as the invisibility characteristics of this group of women in the context of the invisibility of women’s football in this period and in the context of the political transition until 1982. In the repressive context of late Francoism and given the validity until 1978 of laws that expressly persecuted homosexuality, social, cultural, legal, and political pressure had a very important impact on lesbian women who participated in the incipient practice of football in Spain in the 1970s. Some of these players built gay social networks through sports clubs and later started clandestine meetings in bars and private celebrations. The period studied—between 1970 and 1982—coincided with the rebirth of women’s football in Spain and the international emergence of this sport. The research has been based on the use of in-depth interview as a method and historiographical technique that has allowed us to obtain the life stories of nine lesbian or heterosexual women football players in different Spanish cities (who in general have lived and live in a private sexual identity) and two coaches linked to women’s teams. These sources have been expanded and contrasted from others of a documentary nature (specialized press and bibliography) to reconstruct the context studied and contrast the reliability of the information collected. In conclusion, it has been established that, despite the low visibility of women’s football and homosexuality, the legal pressure of the period and the opposition of the public authorities and institutions of the dictatorship, the field of football allowed these women to overcome some of the difficulties in the process of building their identity and discrimination based on sexual orientation. In turn, support networks—especially of teammates—private parties and atmosphere bars, were fundamental to the life experience of young lesbian athletes in the still repressive context of the end of the Franco dictatorship and the first years of the young democratic regime in Spain.
Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study
Authors: McBride Grace McKenzie , Rumbold Alice R , Keir Amy K , Kunnel Aline , Buxton Michael , Jones Susanne , Summers Laura , Stark Michael , Grzeskowiak Luke E 
Published: November 2023

ObjectiveThis study aims: (a) to evaluate patterns of domperidone dispensing to mothers of very preterm (<32 weeks gestation) infants born before and after 2014 when international recommendations were made to limit its use and (b) to examine characteristics associated with domperidone dispensing and impacts on breast milk feeding rates at infant hospital discharge.DesignRetrospective audit using linked electronic medical records and hospital pharmacy records.SettingTertiary-referral neonatal intensive care unit at the Women’s and Children’s Hospital in South Australia.PatientsMothers of preterm infants admitted to neonatal intensive care from January 2004 to December 2018.Main outcome measuresRate of domperidone dispensing compared pre-2014 and post-2014 recommendations using interrupted time series analyses, and breast milk feeding rates at infant discharge based on domperidone treatment status, adjusted for other factors known to influence breast milk production.ResultsOverall, domperidone was dispensed to 691 (41%) of 1688 mothers. Prior to 2014 recommendations, the proportion of women dispensed domperidone was stable. Following the recommendations, there was a significant reduction in trend (−2.55% per half year, 95% CI −4.57% to –0.53%;), reflecting less domperidone dispensing.Breast milk feeding rates at discharge remained consistently lower in infants of women dispensed domperidone than those who were not (adjusted OR 0.58, 95% CI 0.45 to 0.75).ConclusionDomperidone dispensing in mothers of hospitalised very preterm infants has declined over time following international regulatory warnings. Breast milk feeding rates remain lower in mothers prescribed domperidone, suggesting further research is needed to optimise lactation support for mothers of very preterm infants.
Household Cohabitation Patterns in Multiethnic Seventeenth-Century Lviv
Authors: Wysmułek Jakub 
Published: November 2023

Abstract
Lviv, a mid-sized city in the eastern borderlands of the Polish-Lithuanian Commonwealth, numbered approximately 10,000 inhabitants in the second half of the seventeenth century. Its wealth, strategic location, and role as a trade center with the East contributed to significant ethno-religious diversity, with influential communities of Ruthenians (Ukrainians), Armenians, and Jews, alongside the Catholic majority. Detailed analysis of the 1662 Lviv poll tax register and other sources reveals the social composition and size of individual households, as well as their location in the city, houses’ construction material, and plot sizes. The results reveal diverse domestic arrangements influenced not only by individual socio-economic factors but also by the structural and cultural characteristics of the urban space.
Added in Translation: Keywords for the Study of Javanese Islamic Texts
Authors: Ricci Ronit 
Published: November 2023

Abstract
The idea of keywords was introduced in Raymond Williams’ seminal Keywords. A Vocabulary of Culture and Society (1976), and has since had a profound influence on research in multiple fields. This article explores what the idea of keywords might contribute to the study of interlinear translations from Arabic into Javanese. The interlinear translation, which presents an Arabic text with a word-for-word Javanese translation appearing between its lines, is a space where languages, beliefs, and entire histories encounter one another on the page. Taking as my example the 1864 interlinear Babad Maulud (a Javanese translation of the Arabic Maulid Syaraf al-Anām, recited on the Prophet Muhammad’s birthday), I suggest that despite the Javanese translator’s overall literal translation strategy which attempted to duplicate the original, he or she decided to add “Javanese keywords” at particular points in the translation, with such exceptions revealing contemporary Javanese understandings of social etiquette, identity and genealogy.
Estimating microhaplotype allele frequencies from low-coverage or pooled sequencing data
Authors: Delomas Thomas A. , Willis Stuart C. 
Published: November 2023

Abstract
Background
Microhaplotypes have the potential to be more cost-effective than SNPs for applications that require genetic panels of highly variable loci. However, development of microhaplotype panels is hindered by a lack of methods for estimating microhaplotype allele frequency from low-coverage whole genome sequencing or pooled sequencing (pool-seq) data.

Results
We developed new methods for estimating microhaplotype allele frequency from low-coverage whole genome sequence and pool-seq data. We validated these methods using datasets from three non-model organisms. These methods allowed estimation of allele frequency and expected heterozygosity at depths routinely achieved from pooled sequencing.

Conclusions
These new methods will allow microhaplotype panels to be designed using low-coverage WGS and pool-seq data to discover and evaluate candidate loci. The python script implementing the two methods and documentation are available at https://www.github.com/delomast/mhFromLowDepSeq.
Multi-genome comprehensive identification of SSR/SV and development of molecular markers database to serve Sorghum bicolor (L.) breeding
Authors: An Yanlin , Xia Xiaobo , Zheng Huayan , Yu Shirui , Jing Tingting , Zhang Feng 
Published: November 2023

Abstract
Background
As an important food and cash crop, identification of DNA molecular markers is of great significance for molecular marker-assisted breeding of Sorghum (Sorghum bicolor (L.) moench). Although some sorghum-related mutation databases have been published, the special SSR and SV databases still need to be constructed and updated.

Results
In this study, the quality of 18 different sorghum genomes was evaluated, and two genomes were assembled at chromosome level. Through the identification and comparative analysis of SSR loci in these genomes, the distribution characteristics of SSR in the above sorghum genomes were initially revealed. At the same time, five representative reference genomes were selected to identify the structural variation of sorghum. Finally, a convenient SSR/SV database of sorghum was constructed by integrating the above results (http://www.sorghum.top:8079/;http://43.154.129.150:8079/;http://47.106.184.91:8079/). Users can query the information of related sites and primer pairs.

Conclusions
Anyway, our research provides convenience for sorghum researchers and will play an active role in sorghum molecular marker-assisted breeding.
Phytohormones and candidate genes synergistically regulate fruitlet abscission in Areca catechu L.
Authors: Li Jia , Chen Yunche , Zhou Guangzhen , Li Meng 
Published: November 2023

Abstract
Background
The fruit population of most plants is under the control of a process named “physiological drop” to selectively abort some developing fruitlets. However, frequent fruitlet abscission severely restricts the yield of Areca catechu. To reveal the physiological and molecular variations in this process, we detected the variation of phytohormone levels in abscised and non-abscised fruitlets in A. catechu.

Results
The levels of gibberellin acid, jasmonic acid, salicylic acid, abscisic acid and zeatin were elevated, while the indole-3-acetic acid and indole-3-carboxaldehyde levels were declined in the “about-to-abscise” part (AB) of abscission zone (AZ) compared to the “non-abscised” part (CK). Then the differentially expressed genes (DEGs) between AB and CK were screened based on transcriptome data. DEGs involved in phytohormone synthesis, response and transportation were identified as key genes. Genes related to cell wall biosynthesis, degradation, loosening and modification, and critical processes during fruit abscission were identified as role players. In addition, genes encoding transcription factors, such as NAC, ERF, WRKY, MADS and Zinc Finger proteins, showed differentially expressed patterns between AB and CK, were also identified as candidates.

Conclusions
These results unraveled a phytohormone signaling cross talk and key genes involved in the fruitlet abscission process in A. catechu. This study not only provides a theoretical basis for fruitlet abscission in A. catechu, but also identified many candidate genes or potential molecular markers for further breeding of fruit trees.
Association of body mass index with perioperative blood transfusion and short-term clinical outcomes in patients undergoing isolated coronary artery bypass grafting
Authors: Gao Jie , Ji Hongwen 
Published: November 2023

Abstract
Background
Few studies have considered outcomes among low body mass index (BMI) cohorts undergoing coronary artery bypass grafting (CABG). This study aims to investigate the effects of low body weight on blood transfusion and perioperative outcomes in patients undergoing isolated CABG.

Methods
This retrospective study enrolled consecutive cases from a single-center between January 2008 and December 2018. Low body weight/underweight was defined as a BMI < 18.5 kg/m², while normal BMI was defined as 18.5 ≤ BMI < 24.0 kg/m². The primary endpoint was the perioperative red blood cell (RBC) transfusion rate. Secondary endpoints include platelet and plasma transfusion rates, transfusion volume for all blood components, hospital length of stay, and the occurrence of adverse events including prolonged mechanical ventilation, re-intubation, re-operation, acute kidney injury, and 30-day all-cause mortality.

Results
A total of 7,620 patients were included in this study. After 1:1 propensity score matching, 130 pairs were formed, with 61 pairs in the on-pump group and 69 pairs in the off-pump group. Baseline characteristics were comparable between the matched groups. Low body weight independently increased the risk of RBC transfusion (on-pump: OR = 3.837, 95% CI = 1.213–12.144, p = 0.022; off-pump: OR = 3.630, 95% CI = 1.875–5.313, p < 0.001). Moreover, within the on-pump group of the original cohort, BMI of < 18.5 kg/m² was independently correlated with increased risk of re-intubation (OR = 5.365, 95% CI = 1.159 to 24.833, p = 0.032), re-operation (OR = 4.650, 95% CI = 1.019 to 21.210, p = 0.047), and 30-day all-cause mortality (OR = 10.325, 95% CI = 2.011 to 53.020, p = 0.005).

Conclusion
BMI < 18.5 kg/m² was identified as an independent risk factor for increased perioperative RBC transfusion rate in patient underwent isolated CABG with or without CPB. Only on-pump underweight patients in the original cohort exhibited an increased risk for re-intubation, re-operation, and 30-day all-cause mortality. Physicians and healthcare systems should consider these findings to improve management for this population.
Current situation and needs analysis of medical staff first aid ability in China: a cross-sectional study
Authors: Wang Juntao , Lv Chuanzhu , Song Xingyue , Hu Yanlan , Hao Wenjie , He Lanfen , Chen Yu , Gan Yong , Han Xiaotong , Yan Shijiao 
Published: November 2023

Abstract
Objectives
We aim to understand the current situation of the first aid ability and training needs of Chinese medical personnel to provide a scientific basis for formulating the contents and methods of emergency medical rescue training and thereby improve the first aid level of Chinese medical personnel.

Methods
A cross-sectional survey was conducted between June 2022 and February 2023 using a two-stage cluster sampling method with a structured questionnaire sent to medical workers in 12 provinces in China. 14,527 questionnaires were included in this study. Data were collected on demographic characteristics, first aid knowledge and skills, and training needs. Variance analysis was used to compare the difference between the first aid ability and training needs of medical staff in different hospitals, and multiple linear regression analysis was carried out to evaluate first aid ability and training needs.

Result
The study included 6041 patients (41.6%) in tertiary hospitals, 5838 patients (40.2%) in secondary hospitals, and 2648 patients (18.2%) in primary hospitals. There were significant differences in the first aid ability and training needs of medical staff in hospitals of different levels (p < 0.001). The score of first aid knowledge and skills in tertiary hospitals was the highest (209.7 ± 45.0), and the score of training needs in primary hospitals was the highest (240.6 ± 44.0). There was a significant correlation between first aid ability and training needs score (p < 0.001). Multiple linear regression analysis shows that geographic region, age, work tenure, gender, job title, department, professional title, monthly income, and hospital level are the influencing factors of training demand.

Conclusion
Medical staff in primary hospitals generally have low first aid knowledge and skills and a strong willingness to train. Therefore, it is imperative to strengthen the training of first aid ability and research training strategies. The level of the hospital is closely related to the level of first aid, so it is necessary to recognize the commonalities and differences in medical staff’s demand for first aid knowledge and skills and carry out targeted education and training.
Mapping regional variability of exclusive breastfeeding and its determinants at different infant’s age in Tanzania
Authors: Jahanpour Ola Farid , Okango Elphas Luchemo , Todd Jim , Mwambi Henry , Mahande Michael J. 
Published: November 2023

Abstract
Introduction
Despite its numerous benefits, exclusive breastfeeding (EBF) remains an underutilized practice. Enhancing EBF uptake necessitates a focused approach targeting regions where its adoption is suboptimal. This study aimed to investigate regional disparities in EBF practices and identify determinants of EBF among infants aged 0–1, 2–3, and 4–5 months in Tanzania.

Methods
This cross-sectional study utilized data from the 2015/16 Tanzania Demographic and Health Survey. A total of 1,015 infants aged 0–5 met the inclusion criteria, comprising 378 aged 0–1 month, 334 at 2–3 months, and 303 at 4–5 months. EBF practices were assessed using a 24-hour recall method. A generalized linear mixed model, with fixed covariates encompassing infant and maternal attributes and clusters for enumeration areas (EAs) and regions, was employed to estimate EBF proportions.

Results
Regional disparities in EBF were evident among infants aged 0–1, 2–3, and 4–5 months, with decline in EBF proportions as an infant’s age increases. This pattern was observed nationwide. Regional and EA factors influenced the EBF practices at 0–1 and 2–3 months, accounting for 17–40% of the variability at the regional level and 40–63% at the EA level. Literacy level among mothers had a significant impact on EBF practices at 2–3 months (e.g., women who could read whole sentences; AOR = 3.2, 95% CI 1.1,8.8).

Conclusion
Regional disparities in EBF proportions exist in Tanzania, and further studies are needed to understand their underlying causes. Targeted interventions should prioritize regions with lower EBF proportions. This study highlights the clustering of EBF practices at 0–1 and 2–3 months on both regional and EA levels. Conducting studies in smaller geographical areas may enhance our understanding of the enablers and barriers to EBF and guide interventions to promote recommended EBF practices.
Efficacy and safety of venetoclax in patients with relapsed/refractory multiple myeloma: a meta-analysis
Authors: Gao Xiaohui , Zeng Hui , Zhao Xiaoyan , Wu Haibing , Yan Minchao , Li Yuan , Zhang Gang , Sun Fei 
Published: November 2023

Abstract
Background
Venetoclax is clinically active in treating relapsed/refractory multiple myeloma (RRMM). This study evaluated the efficacy and safety of venetoclax or venetoclax with other agents in treating RRMM.

Methods
PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched. We included studies investigating the efficacy and safety of venetoclax or venetoclax with other agents in treating RRMM. Overall response rates (ORR), stringent complete response rates (sCR), complete response rates (CR), very good partial response rates (VGPR), partial response rates (PR), stable disease (SD), progressive disease (PD) and adverse events were synthesized using either a random-effects model or a fixed-effects model.

Results
A total of 7 clinical trials with 482 patients with RRMM were included. Concerning venetoclax with other agents, the pooled ORR, sCR, CR, VGPR, PR, SD, and PD were 0.76 (95% CIs: 0.62, 0.87), 0.11 (95% CIs: 0.04, 0.21), 0.18 (95% CIs: 0.11, 0.26), 0.16 (95% CIs: 0.12, 0.25), 0.29 (95% CIs: 0.25, 0.34), 0.07 (95% CIs: 0.05, 0.10), and 0.11 (95% CIs: 0.04, 0.23). The overall rate of adverse events ≥ Grade 3 was 0.84 (95% CIs: 0.77, 0.91). The most common non-hematologic adverse events were nausea, diarrhea, fatigue, back pain, and vomiting; hematologic adverse events included thrombocytopenia, neutropenia, anemia, leukopenia, and lymphopenia.

Conclusions
This study indicates that venetoclax alone or in combination with other agents reveals favorable treatment responses and acceptable adverse events in treating RRMM.