bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing Surgical Wound Care in Obstetrics and Gynecology
Authors: Salinaro Julia R. , Jones Penny S. , Beatty Amelia B. , Dotters-Katz Sarah K. , Kuller Jeffrey A. , Kerner Nicole P. 
Published: October 2023

Importance
Obstetrics and gynecology (OB/GYN) accounts for at least half of all open abdominal surgeries performed. Rates of surgical wound complications after open procedures in OB/GYN range from 5% to 35%. Therefore, optimizing management of surgical wound complications has the potential to significantly reduce cost and morbidity. However, guidelines addressing best practices for wound care in OB/GYN are limited.

Objective
The objectives of this review are to describe the fundamentals of wound healing and to evaluate available evidence addressing surgical wound care. Based on these data, we provide recommendations for management of extrafascial surgical wound dehiscence after OB/GYN procedures.

Evidence Acquisition
Literature search was performed in PubMed, Medline, OVID, and the Cochrane database. Relevant guidelines, systematic reviews, and original research articles investigating mechanisms of wound healing, types of wound closure, and management of surgical wound complications were reviewed.

Results
Surgical wound complications in OB/GYN are associated with significant cost and morbidity. One of the most common complications is extrafascial dehiscence, which may occur in the setting of hematomas, seromas, or infection. Management includes early debridement and treatment of any underlying infection until healthy granulation tissue is present. For wounds healing by secondary intention, advanced moisture retentive dressings reduce time to healing and are cost-effective when compared with conventional wet-to-dry gauze dressings. Negative pressure wound therapy can be applied to deeper wounds healing by secondary intention. Review of published evidence also supports the use of delayed reclosure to expedite wound healing for select patients.

Conclusions
Optimizing surgical wound care has the potential to reduce the cost and morbidity associated with surgical wound complications in OB/GYN. Advanced moisture retentive dressings should be considered for wounds healing by secondary intention. Data support delayed reclosure for select patients, although further studies are needed.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning Objectives
After reading this article, the provider will be better able to explain the clinical significance of surgical wound complications, particularly in OB/GYN; identify the stages of wound healing and types of wound closure; discuss the TIME framework for wound care; and describe a recommended approach for the management of extrafascial wound dehiscence.
A New Era in Magnetic Resonance Contrast Media
Authors: Runge Val M. , Heverhagen Johannes T. 
Published: October 2023

AbstractNext-generation gadolinium-based contrast agents (GBCAs), including both high relaxivity agents and targeted agents, and manganese-based agents with a high probably of commercial success are discussed in some depth. It is highly likely that gadopiclenol and gadoquatrane, both next-generation high relaxivity gadolinium-based compounds, will come in time to replace the current macrocyclic gadolinium chelates, despite the wide acceptance, very high safety profile, and high stability of the latter group. Current research has also made possible the development of 2 new targeted gadolinium chelates, which look very promising, with the potential to improve cancer detection (for both MT218 and ProCA32.collagen) as well as diseases of collagen (for the latter agent). Further work with manganese-based compounds, a topic left fallow for more than 20 years, has also now produced 2 agents with high potential for clinical use, one (manganese chloride tetrahydrate, administered orally) developed primarily for imaging of the liver and the other (Mn-PyC3A, administered intravenously) as a gadolinium-free replacement for the GBCAs. New detail has recently emerged regarding specific circumscribed subregions of the brain with specialized cytoarchitecture and functions in which high gadolinium concentrations are seen following injection of the linear agent gadodiamide. These findings pave the way for tailored functional neurological testing, specifically in patients at potential risk due to the continued wide use in many countries across the world of the linear GBCAs. The impact of artificial intelligence is also critically discussed, with its most likely applications being dose reduction and new clinical indications.
Hoeflea poritis sp. nov., isolated from a bleached scleractinian coral Porites lutea
Authors: Zhang Guoqiang , Zhang Zongyao , Sajid Sumbal , Wei Qiaoyan , Cai Lin 
Published: October 2023

A Gram-stain-negative, aerobic, rod-shaped, nonmotile and yellow-pigmented bacterium designated E7-10T was isolated from a bleached scleractinian coral Porites lutea. Strain E7-10T grew with 1.0–8.0 % (w/v) NaCl (optimum, 4.0 %), at 18–41 °C (optimum, 28 °C) and at pH 6.0–10.0 (optimum, pH 8.0). Phylogenetic analysis using 16S rRNA gene sequences revealed that E7-10T formed a lineage within the genus

Hoeflea

, but it was distinct from the closest species ‘Hoeflea prorocentri’ PM5-8T, showing 98.01 % sequence similarity. The predominant cellular fatty acids of E7-10T were summed feature 8 (26.7 %), C18 : 1
ω7c 11-methyl (26.2 %), C16 : 0 (20.8 %) and C19 : 0 cyclo ω8c (17.9 %). The major respiratory quinone was Q-10. The polar lipids mainly comprised phosphatidylethanolamine, two glycolipids and five phospholipids. The genome size of E7-10T was 5.58 Mb with G+C content 60.27 mol%. The digital DNA–DNA hybridization and average nucleotide identity values between the genomes of strains E7-10T and PM5-8T were 19.50 and 75.95 %, respectively, which were both below the defined cutoff values (70 % and 95–96 %, respectively) for species delimitation. Thus, strain E7-10T represents a novel species within the genus

Hoeflea

, for which the name Hoeflea poritis sp. nov. is proposed. The type strain is E7-10T (=JCM 35852T=MCCC 1K08229T).
Long-TermIn VivoMolecular Monitoring Using Aptamer-Graphene Microtransistors
Authors: Wu Guangfu , Zhang Eric T. , Qiang Yingqi , Esmonde Colin , Chen Xingchi , Wei Zichao , Song Yang , Zhang Xincheng , Schneider Michael J. , Li Huijie , Sun He , Weng Zhengyan , Santaniello Sabato , He Jie , Lai Rebecca Y. , Li Yan , Bruchas Michael R. , Zhang Yi 
Published: October 2023

AbstractLong-term, real-time molecular monitoring in complex biological environments is critical for our ability to understand, prevent, diagnose, and manage human diseases. Aptamer-based electrochemical biosensors possess the promise due to their generalizability and a high degree of selectivity. Nevertheless, the operation of existing aptamer-based biosensorsin vivois limited to a few hours. Here, we report a first-generation long-termin vivomolecular monitoring platform, named aptamer-graphene microtransistors (AGMs). The AGM incorporates a layer of pyrene- (polyethylene glycol)5-alcohol and DNase inhibitor-doped polyacrylamide hydrogel coating to reduce biofouling and aptamer degradation. As a demonstration of function and generalizability, the AGM achieves the detection of biomolecules such as dopamine and serotonin in undiluted whole blood at 37 °C for 11 days. Furthermore, the AGM successfully captures optically evoked dopamine releasein vivoin mice for over one week and demonstrates the capability to monitor behaviorally-induced endogenous dopamine release even after eight days of implantation in freely moving mice. The results reported in this work establish the potential for chronic aptamer-based molecular monitoring platforms, and thus serve as a new benchmark for molecular monitoring using aptamer-based technology.
Transporter-mediated depletion of extracellular proline directly contributes to plant pattern-triggered immunity against a bacterial pathogen
Authors: Rogan Conner J. , Pang Yin-Yuin , Mathews Sophie D. , Turner Sydney E. , Weisberg Alexandra J. , Lehmann Silke , Rentsch Doris , Anderson Jeffrey C. 
Published: October 2023

AbstractPlants possess cell surface-localized immune receptors that detect pathogen-associated molecular patterns (PAMPs) and initiate defenses that provide effective resistance against microbial pathogens. Many PAMP-induced signaling pathways and cellular responses are known, yet how pattern-triggered immunity (PTI) limits pathogen growth in plants is poorly understood. Through a combined metabolomics and genetics approach, we discovered that plant-exuded proline is a virulence-inducing signal and nutrient for the bacterial pathogenPseudomonas syringae, and that PAMP-induced depletion of proline from the extracellular spaces of Arabidopsis leaves directly contributes to PTI againstP. syringae. We further show that PAMP-induced depletion of extracellular proline requires the amino acid transporterLysineHistidineTransporter1(LHT1). This study demonstrates that depletion of a single extracellular metabolite is an effective component of plant innate immunity. Given the important role for amino acids as nutrients for microbial growth, their depletion at sites of infection may be a broadly effective means for defense against many pathogens.
MetaGIN: A Lightweight Framework for Molecular Property Prediction
Authors: Zhang Xuan , Chen Cheng , Wang Xiaoting , Jiang Haitao , Zhao Wei , Cui Xuefeng 
Published: October 2023

AbstractRecent advancements in AI-based synthesis of small molecules have led to the creation of extensive databases, housing billions of small molecules. Given this vast scale, traditional quantum chemistry (QC) methods become inefficient for determining the chemical and physical properties of such an extensive array of molecules. As these properties are key to new drug research and development, deep learning techniques have recently been developed. Here, we present MetaGIN, a lightweight framework designed for molecular property prediction.While traditional GNN models with 1-hop edges (i.e., covalent bonds) are sufficient for abstract graph representation, they are inadequate for capturing 3D features. Our MetaGIN model shows that including 2-hop and 3-hop edges (representing bond and torsion angles, respectively) is crucial to fully comprehend the intricacies of 3D molecules. Moreover, MetaGIN is a streamlined model with fewer than 10 million parameters, making it ideal for fine-tuning on a single GPU. It also adopts the widely acknowledged MetaFormer framework, which has consistently shown high accuracy in many computer vision tasks.Through our experiments, MetaGIN achieves a mean absolute error (MAE) of 0.0851 with just 8.87M parameters on the PCQM4Mv2 dataset. Furthermore, MetaGIN outperforms leading techniques, showcasing superior performance across several datasets in the MoleculeNet benchmark.
Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
Authors: Lee Sung Hoon , Kang Tae-Yun , Levchenko Andre 
Published: October 2023

AbstractResponses of endothelial cells to elevated levels of Vascular Endothelial Growth Factor (VEGF), frequently accompanying local decrease in oxygen supply, include loosening of cell contacts, rearrangement of cells in the process of vessel remodeling and ultimately, angiogenic growth. How these complex processes, occurring on diverse time scales, are coordinated and how they are guided by a single key signaling input, is still incompletely understood. Here we show that the various phenotypic responses associated with VEGF signaling are controlled at different steps of a pathway involving sequential activation of Src, TEM4, YAP and components of pro-angiogenic Notch signaling. Strikingly, due to feedback regulation at different pathway levels, the functional outcomes are controlled by oscillations of the pathway components occurring on distinct time scales. Deeper pathway layers integrate faster upstream responses and control progressively slower phenotypic outcomes. This signal decoding pathway organization can ensure a high degree of complexity in a vital physiological process.
Family ties: examining family functioning and alcohol use among American Indian youth
Authors: Douglass Morgan A. , Crabtree Meghan A. , Stanley Linda R. , Swaim Randall C. , Prince Mark A. 
Published: October 2023

Purpose
This study aims to examine a second-order latent variable of family functioning built from two established protective factors for American Indian (AI) youth, i.e. family cohesion and parental monitoring. This study then examines if family functioning is related to alcohol use frequency or age of initiation for AI youth. Additionally, this study examines if family functioning served as a moderator for the risk factor of peer alcohol use.

Design/methodology/approach
Data came from the 2021 Our Youth, Our Future survey. Participants were 4,373 AI adolescents from Grades 6–12 across the contiguous USA. Structural equation modeling (SEM) was used to test the latent variable of family functioning. Structural paths and interaction terms between peer use and family functioning were added to the SEM to explore direct and moderating effects.

Findings
Family cohesion and parental monitoring were best represented by a second-order latent variable of family functioning, which was related to later initiation and lower alcohol use frequency.

Practical implications
The findings regarding the initiation of alcohol use may be applicable to prevention programs, with family functioning serving as a protective factor for the initiation of alcohol use. Programs working toward alcohol prevention may be best served by focusing on family-based programs.

Originality/value
The latent variable of family functioning is appropriate for use in AI samples. Family functioning, which is an inherent resilience factor in AI communities, was shown to be protective against harmful alcohol use behaviors.
Trade unions and institutional power resources in the United Kingdom
Authors: Rigby Mike , García Calavia Miguel Angel 
Published: October 2023

PurposeThe paper examines the approach of United Kingdom (UK) Trade Unions to the use of institutional power resources (IPR) in the second half of the twentieth century.Design/methodology/approachUsing secondary material, it examines the unions' approach to IPR in three cases; collective bargaining; worker representation and trade union structure.FindingsThe paper concludes that unions did not appreciate the importance of, and lacked a strategic approach to, IPR. Although employer and government action were largely responsible for the decline of industrial relations institutions, the failure of the unions to engage with IPR contributed to this process. It explains the failure of the unions to engage with IPR by reference to their lack of strategic capabilities and skills in relation to power resources (PRs) in general and IPR in particular.Research limitations/implicationsIt would have been interesting to collect primary data via interviews with union actors from the period examined to test the interpretation of secondary data contained in the article.Practical implicationsThe paper has identified the kind of strategic decision-making which is necessary for unions to engage effectively with IPR. It is has also indicated the key skills which unions need to develop to be able to manage their engagement with IPR.Social implicationsThe paper has implications for the role of trade unions in society, showing the need for them to develop narratives to convince society of the importance of their role and action and to develop the skills which enable them to connect with other social groups, e.g. intermediation, engagement with coalitional resources.Originality/valueAnalysis of the decline of industrial relations institutions in this period has emphasized the role of employers and the state. This paper contributes to a more balanced perspective on this decline by drawing attention to the lack of a union strategy towards IPR and the importance of the detail of the management and employment of power resources.
Lessons from the experience of adolescent migrants during the COVID-19 lockdown in Switzerland: a qualitative study
Authors: Heiniger Caroline , Suris Joan-Carles , Barrense-Dias Yara 
Published: October 2023

Purpose
Three years after the COVID epidemic and the measures put in place by governments, the authors still cannot measure the full impact of them on the well-being and mental health of adolescents. This population was particularly impacted by this crisis, and some subgroups of young people, such as those from migration backgrounds, have been confronted with additional challenges. This paper aims to explore and describe the perspective and experience of migrant adolescents during the lockdown period

Design/methodology/approach
The authors performed 13 semi-structured interviews with migrant adolescents (nine females, median age 16) at the pediatric policlinic of Lausanne University Hospital in Switzerland between November 2020 and January 2021. Participants had been living in Switzerland for an average of 2.3 years. Three of them were staying in a refugee reception centre. A thematic content analysis was carried out to extract themes and topics.

Findings
Participants had difficulty understanding information about COVID-19 in general. Remote learning was described as stressful due to various factors and lockdown had an impact on their future plans, such as finding an apprenticeship. Some young people were already socially isolated, but families were generally supportive. They expressed particular concerns, such as the family’s financial situation and the difficulty of living in refugee reception centres.

Practical implications
In the event of further lockdown, special attention must be paid to these adolescents to ensure their proper development and integration. Comprehensive follow-up of this population during and after the pandemic is essential.

Originality/value
This study provides a better understanding of the pandemic experience of migrant adolescents and underlines their difficulties.
Speak up! brands’ responsiveness matters: consumer reactions to brand communications in the early stages of a crisis
Authors: Garcia-Collart Tessa 
Published: October 2023

Purpose
In an effort to provide insights that nurture the future of brand relationships, this paper aims to examine the impact of brand communications on consumption behavior during critical events that significantly impact the marketplace. Specifically, this research focuses on external crises (i.e. global health crises, natural disasters and regional conflicts) beyond the control of the corporations that govern brands. It does so by exploring the most effective brand communication strategies at the onset of a crisis when brands may shift promotional content to more sensitive, crisis-related content as a means to connect with consumers. Furthermore, this paper seeks to understand which consumer segment will benefit most from brands’ crisis-related content.

Design/methodology/approach
This research introduces two empirical studies (combined sample = 490), using student and online participant samples.

Findings
Results from this work demonstrate that at the onset of a crisis, consumers’ attitudes, brand engagement, and self-brand connections significantly increase after visualizing crisis-related versus noncrisis-related brand messages. Results also reveal that consumers who feel less socially connected will react more favorably to brand communications that contain crisis-related content (i.e. informative or emotional content related to the crisis) than non-crisis-related content (i.e. marketing content aimed to promote and advertise the brand, product and/or services).

Research limitations/implications
While the effect of crisis communications on consumption behavior and the moderating effect of social connections is explored, the underlying mechanism of these effects is not investigated in this study. Therefore, future research might consider evaluating the mechanisms that drive these effects.

Practical implications
This work builds on past research to help establish that during early critical times, marketing managers should include crisis-related content in their communications, which will increase consumers’ positive reactions toward the brand.

Social implications
Another implication of this work is that it underscores the significance of crisis-related brand communications as an inclusive practice because these are particularly well-received among vulnerable consumer segments, such as those who feel less socially connected during critical times.

Originality/value
Proactive communication strategies allow brands to better manage external critical challenges. As brands navigate a postpandemic marketplace, this research highlights the adaptations that managers can make to their communication strategies at peak uncertain times, such as the earlier stages of an external crisis.
Impact of nature on the mental health and well-being of the ICU survivors: an interpretative phenomenological analysis
Authors: Kaur Supreet 
Published: October 2023

Purpose
The purpose of this study is to comprehend the traumatic experiences of intensive care unit (ICU) patients during the COVID-19 pandemic and the impact of the same post-discharge. It assesses the role of nature and open green spaces on the mental health and well-being of critically ill patients.

Design/methodology/approach
Using interpretative phenomenological analysis, this study highlights the major factors contributing to adverse mental health and well-being. The subjects were interviewed using semi-structured personal interview techniques. Thematic content analysis was adapted to derive the major themes apparent in the succinctly rich information gathered from the participants.

Findings
The findings cast light on the significant role of nature and open green spaces in psychotherapeutic healing post-discharge of intensive care survivors.

Originality/value
The study is novel and adds to the existing literature in an advanced manner. To the best of the author’s knowledge, no other study was witnessed, especially in the Indian context, confirming the relationship between humans and nature with ICU patients as a subset.
Exercise decision of employee stock options: does Herding Bias influence the employees' decision?
Authors: Arora Manpreet K. , Kaur Sukhpreet 
Published: October 2023

PurposeEmployee Stock Options [ESOs] have been used widely as a component of employees' compensation. To maximise the incentive effect of these options it is very important to understand the exercise decision of the employees. This is an important financial decision that is dependent on both rational and psychological factors. This paper aims to study the mediating role of Herding Bias on Personality Traits and the employees' decision to exercise ESOs.Design/methodology/approachThe data were collected through a self-structured questionnaire from 210 employees of Banks and NBFCs [Non-Banking Financial Companies] who have received and exercised the ESOs. SPSS MACRO version 25 was used to understand the mediational effect of Herding Bias on Personality Traits and Employees' decision to exercise their ESOs.FindingsThe results showed that Personality Traits affect the employees' decision to exercise their ESOs. The study also shows a partial negative mediating effect of Herding Bias on Personality Traits and employees' decision to exercise ESOs.Originality/valueLimited study has been conducted on how the employees make their decision to exercise ESOs. Although extant studies have touched upon the importance of including behavioural biases in ascertaining the exercise decision of the employees, the predictors of the behavioural biases have not been studied under this context. To the best of the author's knowledge, this study is the first in itself to study the inter-linkage between Personality Traits, Herding Bias and employees' decision to exercise ESOs.