bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periorbital venous stasis may be involved with filler induced malar edema—A duplex ultrasound‐imaging‐based case series
Authors: Schelke L. , Liplavk O. , Cotofana S. , Shah‐Desai S. , Velthuis P. 
Published: October 2023

AbstractIntroductionFiller injections in the periocular region are regarded as a challenging and advanced maneuver in a high‐risk area. Adverse events as malar edema due to filler treatment may occur. To evaluate the possible reasons, the ultrasound images, and medical data of patients that were prospectively referred with malar edema were evaluated.Materials and MethodsA total of 17 patients (26 eyes) with malar edema after hyaluronic acid filler treatment were included. All cases were assessed with an 18 MHz linear ultrasound device. Exact location of the filler material was noted. Relations with clinical data were analyzed using chi‐square tests.ResultsOnset of malar edema after treatment showed a wide range from immediate (0 days) to 3 years. Most patients had an early onset N = 13 (76%), a minority showed late onset N = 4 (24%). In 23 eyes, the filler material was found to be located inside the SMAS. In 3 cases filler material was located on the periosteum of the orbital rim. After duplex‐ultrasound guided filler removal, restored venous flow could be seen in the superficial and/or deep fatty layer often accompanied by flow piercing through the SMAS. Minutes after treatment, clinical improvement of malar edema was observed.ConclusionMalar edema after by filler treatments in the periocular region may be caused by veno‐lymphatic compression by filler deposits.
Poor sleep hygiene practices are associated with a higher increase in sleep problems during the COVID‐19 pandemic: A latent change score model
Authors: Zagaria Andrea , Serena Scarpelli , Musetti Alessandro , Rapelli Giada , De Gennaro Luigi , Plazzi Giuseppe , Franceschini Christian 
Published: September 2023

SummaryThe Coronavirus 2019 (COVID‐19) pandemic significantly influenced physical and mental health worldwide. The present study aimed to investigate changes in sleep problems across three waves of the COVID‐19 pandemic, and to identify potential predictors of the inter‐individual variability around these changes, with a particular focus on the role of detrimental sleep hygiene practices. A total of 352 participants completed an online survey of self‐report questionnaires at three different waves of the COVID‐19 pandemic: T1 (Spring 2020); T2 (Autumn‐Winter 2020); and T3 (Spring 2021). The questionnaires collected information on socio‐demographic and COVID‐19‐related variables, psychological distress (i.e. the Depression Anxiety Stress Scale‐21), sleep hygiene (i.e. the Sleep Hygiene Index) and sleep problems (i.e. the Medical Outcomes Study—Sleep Scale). Latent change score modelling revealed an average increase in sleep problems between T1 and T2 with significant inter‐individual variability. No substantial changes were observed on average between T2 and T3. Notably, poorer sleep hygiene practices were associated with a more pronounced increase in sleep problems between T1 and T2 (β = 0.191, p = 0.013), even after controlling for relevant confounders such as demographic factors, COVID‐19‐related information and psychological distress. These findings expand on previous research regarding the detrimental effects of the pandemic on mental health, suggesting that interventions targeting sleep hygiene practices may be beneficial for mitigating its negative impact on sleep disruptions.
The effects of feeding sodium chloride pellets on the gastric mucosa, acid‐base, and mineral status in exercising horses
Authors: Alshut Farina , Venner Monica , Martinsson Gunilla , Vervuert Ingrid 
Published: September 2023

AbstractBackgroundElectrolyte supplementation may be a risk factor for gastric mucosal lesions, but relevant evidence is limited in horses.HypothesisInvestigate the effects of PO sodium chloride (NaCl) supplementation on the gastric mucosa of exercising horses. We hypothesized that NaCl supplementation would neither cause nor exacerbate existing gastric mucosal damage.AnimalsFifteen 3‐year‐old healthy Warmblood stallions from a stud farm.MethodsPlacebo‐controlled study with a crossover design. Horses were fed either a NaCl pellet at a dosage adequate to replace the electrolyte losses in 10 L sweat or a placebo for 19 days with a washout period of 14 days between treatments. The gastric mucosa was evaluated by gastroscopy before and after treatment. Blood samples were collected for evaluation of acid‐base status, packed cell volume (PCV), and total protein, creatinine and blood urea nitrogen concentrations. Urine was collected, and urine specific gravity, electrolyte, creatinine, and urea concentrations were measured.ResultsThe initial prevalence of gastric mucosal lesions was 85%. Sodium chloride pellets did not adversely affect the gastric mucosa and treatment did not significantly alter the hematologic and serum biochemical variables. Urine creatinine concentrations significantly decreased and urinary sodium concentrations significantly increased after supplementation with NaCl pellets. Water intake did not significantly differ between treatments.Conclusions and Clinical ImportanceDaily NaCl pellet supplementation is a palatable and safe way to replace electrolyte losses from sweating in exercising horses and has no negative effects on the gastric mucosa.
Efficacy of the oral supplement, Equine Omega Complete, for the prevention of gastric ulcers and alpha‐tocopherol supplementation in horses
Authors: Williams Louie Elizabeth , Nieto Jorge , Wensley Fiona , Morgan Jessica M. , Finno Carrie J. , Berryhill Emily H. 
Published: September 2023

AbstractBackgroundOmega‐3 fatty acid and alpha‐tocopherol supplementation reduces gastric ulcer formation in humans and rodents; however, efficacy of prevention in horses is unknown. Equine Omega Complete (EOC) is an oral supplement containing omega‐3 fatty acids and alpha‐tocopherol.Hypothesis/ObjectiveDetermine if EOC supplementation prevents gastric ulcers and increases serum alpha‐tocopherol concentrations in healthy horses.AnimalsNine thoroughbred geldings; 5‐13 years old.MethodsProspective randomized block design, repeated in crossover model. Horses were administered EOC, omeprazole, or water PO for 28 days. Horses underwent an established gastric ulcer induction protocol from days 21‐28 via intermittent feed deprivation. Gastroscopies were performed on days 0, 21, and 28. Serum alpha‐tocopherol concentrations were measured on days 0 and 28. The effects of treatment and time on ulcer grades were assessed with ordinal logistic regression, with significance at P‐value <.05.ResultsUlcer grades increased during ulcer induction in control and EOC but not omeprazole groups (P = .02). Grades increased in EOC‐treated horses after ulcer induction from a median of 1 [95% confidence interval 0‐2.5] (day 0) to 2.5 [1.5‐3.5] (day 28) and were similar to the control group (P = .54). Serum alpha‐tocopherol increased in EOC‐treated horses from day 0 to day 28 (mean 2.2 0.43 μg/mL to 2.96 0.89 μg/mL; P < .001) with high individual variation; this increase was not different from omeprazole or control groups.Conclusion and Clinical ImportanceSupplementation with EOC for 28 days did not prevent gastric ulcer formation nor increase alpha‐tocopherol concentrations relative to the control group.
Effect of esomeprazole with and without a probiotic on fecal dysbiosis, intestinal inflammation, and fecal short‐chain fatty acid concentrations in healthy dogs
Authors: McAtee Rae , Schmid Sarah M. , Tolbert M. Katherine , Hetzel Scott , Suchodolski Jan S. , Pritchard Jessica C. 
Published: September 2023

AbstractBackgroundProton pump inhibitors can cause diarrhea and a transient increase in fecal dysbiosis index in dogs. It is unknown if concurrent probiotic administration mitigates these effects.Objective/HypothesisTo assess the fecal Canine Microbial Dysbiosis Index (CMDI), fecal short chain fatty acid (SCFA), and fecal calprotectin concentrations in dogs administered esomeprazole with and without a probiotic.AnimalsEleven healthy dogs.MethodsProspective, within‐subjects before and after study. All dogs received 7‐day courses of esomeprazole (1 mg/kg PO q 24h) alone followed by esomeprazole with a probiotic (15 billion CFU/kg), separated by a 4‐week washout period. Data were compared between phases using mixed effects ANOVA or generalized estimating equations with post‐hoc Holm adjustment for 2‐way comparisons.ResultsCompared to baseline (mean CMDI −2.66, SD 3.04), fecal CMDI was not different with esomeprazole administration alone (mean CMDI −1.48, SD 3.32, P = .08), but there was a significant increase (Diff 3.05, 95% CI [1.37, 4.74], P < .001, Effect size 2.02) when esomeprazole and a probiotic were administered concurrently (mean CMDI 0.39, SD 2.83). CMDI was significantly higher when esomeprazole was administered with a probiotic than alone (Diff 1.87, 95% CI [0.19, 1.87], P = .02, Effect size 1.24). Fecal calprotectin and SCFA concentrations did not differ between phases. The occurrence of vomiting and diarrhea was not different from baseline when esomeprazole was administered alone (36%/27%) or with a probiotic (46%/9%).Conclusions and Clinical ImportanceIn healthy dogs, concurrent administration of a probiotic is unlikely to lessen adverse effects associated with esomeprazole administration.
‘I don't want to impose on anybody’: Older people and their families discuss their perceptions of risk, cause and care in the context of falls
Authors: Kerr Lucille , Newman Paula , Russo Philip 
Published: September 2023

AbstractBackgroundFalls in hospitalised patients remain an ongoing challenge for healthcare systems internationally. Limited research exists on the perspectives of older people on falls risk, cause and care.ObjectivesThis study explored the experiences of patients and their families after a fall in a healthcare facility.MethodsSemi‐structured interviews were conducted with patients and families to explore the experience of having a fall. Data were analysed thematically.ResultsThe themes that emerged from the 14 interviews included the following: explanations; physical environment; communication; experiences of care; perceptions of risk; ageism; feelings towards the fall; and independence and dignity.ConclusionsThis research emphasises the diversity in older people's experiences after experiencing a fall. Falls prevention should be incorporated as one part of healthy, dignified ageing.Implications for practiceFalls prevention and management strategies should be multifactorial, including enhanced communication with the patient and their families. When engaging in education and awareness, falls prevention should be positioned as one component of independent and dignified healthy ageing.
Plant growth‐promoting rhizobacterium Bacillus cereus AR156 induced systemic resistance against multiple pathogens by priming of camalexin synthesis
Authors: Li Zi‐Jie , Tang Shu‐Ya , Gao Hong‐shan , Ren Jin‐Yao , Xu Pei‐Ling , Dong Wen‐Pan , Zheng Ying , Yang Wei , Yu Yi‐Yang , Guo Jian‐Hua , Luo Yu‐Ming , Niu Dong‐Dong , Jiang Chun‐Hao 
Published: September 2023

AbstractPhytoalexins play a crucial role in plant immunity. However, the mechanism of how phytoalexin is primed by beneficial microorganisms against broad‐spectrum pathogens remains elusive. This study showed that Bacillus cereus AR156 could trigger ISR against broad‐spectrum disease. RNA‐sequencing and camalexin content assays showed that AR156‐triggered ISR can prime the accumulation of camalexin synthesis and secretion‐related genes. Moreover, it was found that AR156‐triggered ISR elevates camalexin accumulation by increasing the expression of camalexin synthesis genes upon pathogen infection. We observed that the priming of camalexin accumulation by AR156 was abolished in cyp71a13 and pad3 mutants. Further investigations reveal that in the wrky33 mutant, the ability of AR156 to prime camalexin accumulation is abolished, and the mediated ISR against the three pathogens is significantly compromised. Furthermore, PEN3 and PDR12, acting as camalexin transporters, participate in AR156‐induced ISR against broad‐spectrum pathogens differently. In addition, salicylic acid and JA/ET signalling pathways participate in AR156‐primed camalexin synthesis to resist pathogens in different forms depending on the pathogen. In summary, B. cereus AR156 triggers ISR against Botrytis cinerea, Pst DC3000 and Phytophthora capsici by priming camalexin synthesis. Our study provides deeper insights into the significant role of camalexin for AR156‐induced ISR against broad‐spectrum pathogens.
Laser capture microdissection provides a novel molecular profile of human primary cutaneous melanoma
Authors: Navrazhina Kristina , Garcet Sandra , Williams Samuel C. , Gulati Nicholas , Kiecker Felix , Frew John W. , Mitsui Hiroshi , Krueger James G. 
Published: September 2023

AbstractMelanoma accounts for the majority of skin cancer‐related mortality, highlighting the need to better understand melanoma initiation and progression. In‐depth molecular analysis of neoplastic melanocytes in whole tissue biopsies may be diluted by inflammatory infiltration, which may obscure gene signatures specific to neoplastic cells. Thus, a method is needed to precisely uncover molecular changes specific to tumor cells from a limited sample of primary melanomas. Here, we performed laser capture microdissection (LCM) and gene expression profiling of patient‐derived frozen sections of pigmented lesions and primary cutaneous melanoma. Compared to bulk tissue analysis, analysis of LCM‐derived samples identified 9528 additional differentially expressed genes (DEGs) including melanocyte‐specific genes like PMEL and TYR, with enriched of pathways related to cell proliferation. LCM methodology also identified potentially targetable kinases specific to melanoma cells that were not detected by bulk tissue analysis. Taken together, our data demonstrate that there are marked differences in gene expression profiles depending on the method of sample isolation. We found that LCM captured higher expression of melanoma‐related genes while whole tissue biopsy identified a wider range of inflammatory markers. Taken together, our data demonstrate that LCM is a valid approach to identify melanoma‐specific changes using a relatively small amount of primary patient‐derived melanoma sample.
To coordinate or not? A configurational approach to understand public organizations' emergency preparedness coordination
Authors: Xiang Tianyi , Chen Yifan 
Published: October 2023

AbstractWith increasing hazard risks, coordinating public agencies to address emerging threats has become a pressing challenge for public administration. However, little empirical research explores why some public organizations actively coordinate with others in preparation for future crises while others do not. The related research relies on correlation‐based approaches and generates inconclusive findings. To further extend current inquiry, this study takes a configurational approach and examines which configurations of organizational attributes—and environmental characteristics—lead to emergency preparedness coordination. A configurational model for emergency preparedness coordination is proposed along with three propositions. We conducted a large‐N fuzzy‐set QCA to examine U.S. public transit agencies' interorganizational coordination in preparation for the extreme weather events. Findings demonstrate that it is the configurations rather than individual attributes that are essential for active preparedness coordination. Both top‐down and bottom‐up mechanisms can achieve active coordination and managerial commitment is a critical contingency factor.
Differential expression of angiogenesis‐related genes in goat uterus and corpus luteum during pregnancy
Authors: Turgut Ali Osman , Korkmaz Ağaoğlu Özgecan 
Published: September 2023

AbstractVascularization and the control of luteal and endometrial development are regulated by hypoxia‐inducible factors (HIFs) and vascular endothelial growth factor (VEGF) during pregnancy. In this study, the mRNA and protein expression levels of HIFs (HIF1A, HIF2A and HIF3A) and VEGF in goat uterine and ovarian tissues during various stages of pregnancy were evaluated. A total of 42 Hair goats were used and were allocated into six groups, namely embryo‐positive (G1), early pregnancy (G2), mid‐term pregnancy (G3), late pregnancy (G4), oocyte‐positive group (G5) and diestrus group (G6). The mRNA expression of the examined genes was evaluated by RT‐qPCR, and protein expression was evaluated by immunohistochemistry (IHC). In caruncles, HIF1A mRNA expression was greater in G1, G2 and G4 than in G3 (p < .05). HIF1A and HIF2A expression was greater in G1 than in G5 (p < .05). In cotyledons, HIF1A, HIF2A and HIF3A mRNA expression was greater in G2 and G3 compared to G4 (p < .05). In luteal tissue, HIF1A mRNA expression was greater in G1 and G2 than in G3 and G4 (p < .05). In the immunohistochemical examination, HIF1A, HIF2A, HIF3A and VEGF immunoreactions were detected in uterine and luteal tissues. Findings suggest that HIFs and VEGF are involved in the regulation of ovarian functions as well as the processes of implantation and placentation.
Fanon's revolutionary murmurs: Toward a critical phenomenology of listening
Authors: Ferrari Martina 
Published: October 2023

AbstractDecolonial, postcolonial, and postmodern criticism is indebted to Frantz Fanon for revealing the hegemony of vision and visual language in Western imperial discourse. Yet, the import of Fanon's critique of coloniality reaches beyond a focus on vision into the sonorous. Attending to the often overlooked auditory dimension of Fanon's work, I argue, brings attention to the role of listening as a condition of possibility of a revolutionary consciousness. Listening to Fanon's careful descriptions of the experience of many Algerians of listening to the National Liberation Front's radio broadcast, The Voice of Free and Fighting Algeria in “This is the Voice of Algeria,” I propose that what makes possible the institution of a revolutionary consciousness is listening to murmurs. Listening to the materiality of voice and sound rather than the propositional content of speech is revolutionary because it challenges core values central to the project of colonial modernity: metaphysical logocentrism and the fungibility to which colonial modernity strives to reduce colonized subjects.
The social identity affordance view: A theory of social identities
Authors: Arango Alejandro , Burgos Adam 
Published: October 2023

AbstractThis article proposes that social identities are best understood as a kind of affordance, a “social identity affordance.” Social identity affordances are possibilities for action and interaction between persons, within a social niche, based on perceived and self‐perceived social group identification. First, the view presented captures and articulates the basic structure of social identities. Second, it explains the multifaceted interplay of such an item in the social field, including not only the complexity of the interpersonal dimensions, but also the multiplicity of registers in which social identities vibrate (ethical, political, psychological, geographical, affective, epistemic). Third, by doing good on (i) and (ii), the view makes social identities intelligible, helping preclude reductive misinterpretations of social identities, either subjective‐only or public‐only. The view has robust descriptive and explanatory power in concrete social contexts and retains the openness of a historically bound type of formation whose specific meanings change over time.
Effects and mechanism of microplastics on organic carbon and nitrogen cycling in agricultural soil: A review
Authors: Ma Yan , Yang Ke , Yu Hong , Tan Wenbing , Gao Yiman , Lv Bowen 
Published: October 2023

AbstractAt present, microplastics (MPs) are a kind of emerging pollutants of concern in the environment, and have a wide and far‐reaching impact on terrestrial ecosystems. This article summarizes the latest research progress of the impact of MPs pollution on the biogeochemical cycle of carbon (C) and nitrogen (N), and summarizes the current situation of MPs pollution in agricultural soil. On the basis of summarizing the effects of MPs on soil physicochemical properties, soil microorganisms and soil plants and animals, this article focuses on how soil MPs affect the C and N cycles by changing these factors. MPs can alter organic matter degradation and C and N cycles by changing the soil physicochemical properties, as well as the soil microbial and enzymatic activities. MPs may alter plants' nutrient uptake processes, which in turn affects the ability of plants to photosynthesize and absorb C and N elements. MPs can affect the survival rate, the growth rate and intestinal injury of soil animals, therefore indirectly affecting the soil C and N cycles. At the same time, this article compares the different effects of conventional plastics and biodegradable plastics on soil, and looks forward to the current research deficiencies and the future research directions of ecotoxicology of MPs on C and N cycle.
An automated respiratory data pipeline for waveform characteristic analysis
Authors: Lusk Savannah , Ward Christopher S. , Chang Andersen , Twitchell‐Heyne Avery , Fattig Shaun , Allen Genevera , Jankowsky Joanna L. , Ray Russell S. 
Published: October 2023

AbstractComprehensive and accurate analysis of respiratory and metabolic data is crucial to modelling congenital, pathogenic and degenerative diseases converging on autonomic control failure. A lack of tools for high‐throughput analysis of respiratory datasets remains a major challenge. We present Breathe Easy, a novel open‐source pipeline for processing raw recordings and associated metadata into operative outcomes, publication‐worthy graphs and robust statistical analyses including QQ and residual plots for assumption queries and data transformations. This pipeline uses a facile graphical user interface for uploading data files, setting waveform feature thresholds and defining experimental variables. Breathe Easy was validated against manual selection by experts, which represents the current standard in the field. We demonstrate Breathe Easy's utility by examining a 2‐year longitudinal study of an Alzheimer's disease mouse model to assess contributions of forebrain pathology in disordered breathing. Whole body plethysmography has become an important experimental outcome measure for a variety of diseases with primary and secondary respiratory indications. Respiratory dysfunction, while not an initial symptom in many of these disorders, often drives disability or death in patient outcomes. Breathe Easy provides an open‐source respiratory analysis tool for all respiratory datasets and represents a necessary improvement upon current analytical methods in the field.
imageKey points
Respiratory dysfunction is a common endpoint for disability and mortality in many disorders throughout life.
Whole body plethysmography in rodents represents a high face‐value method for measuring respiratory outcomes in rodent models of these diseases and disorders.
Analysis of key respiratory variables remains hindered by manual annotation and analysis that leads to low throughput results that often exclude a majority of the recorded data.
Here we present a software suite, Breathe Easy, that automates the process of data selection from raw recordings derived from plethysmography experiments and the analysis of these data into operative outcomes and publication‐worthy graphs with statistics.
We validate Breathe Easy with a terabyte‐scale Alzheimer's dataset that examines the effects of forebrain pathology on respiratory function over 2 years of degeneration.