bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Risk Scores for Thromboprophylaxis in Medically Ill Patients—Rationale and Design of the RICO trial
Authors: Dentali Francesco , Campanini Mauro , Bonaventura Aldo , Fontanella Luca , Zuretti Francesca , Tavecchia Luca , Mumoli Nicola , Gnerre Paola , Ventrella Francesco , Giustozzi Michela , Valerio Antonella , Fontanella Andrea 
Published: November 2023

Abstract
Background Venous thromboembolism (VTE) in hospitalized medically ill patients is a significant cause of morbidity and mortality. Guidelines suggest that VTE and bleeding risk assessment models (RAMs) should be integrated into the clinical decision-making process on thromboprophylaxis. However, poor evidence is available comparing the use of a RAM versus clinical judgement in evaluating VTE and bleeding occurrence.
Methods Reducing Important Clinical Outcomes in hospitalized medical ill patients (RICO) is a multicenter, cluster-randomized, controlled clinical trial (ClinicalTrials.gov Identifier: NCT04267718). Acutely ill patients hospitalized in Internal Medicine wards are randomized to the use of RAMs—namely the Padua Prediction Score and the International Medical Prevention Registry on Venous Thromboembolism Bleeding Score—or to clinical judgement. The primary study outcome is a composite of symptomatic objectively confirmed VTE and major bleeding at 90-day follow-up. Secondary endpoints include the evaluation of clinical outcomes at hospital discharge and the assessment of VTE prophylaxis prescription during the study period. In order to demonstrate a 50% reduction in the primary outcome in the experimental group and assuming an incidence of the primary outcome of 3.5% in the control group at 90-day; 2,844 patients across 32 centers will be included in the study.
Discussion The RICO trial is a randomized study of clinical management assessing the role of RAMs in hospitalized medical ill patients with the aim of reducing VTE and bleeding occurrence. The study has the potential to improve clinical practice since VTE still represents an important cause of morbidity and mortality in this setting.
Near-Infrared Spectroscopy for Spinal Cord Monitoring—A Roadmap to Translational Research in Aortic Medicine
Authors: von Aspern Konstantin , Haunschild Josephina , Garbade Jens , Etz Christian D. 
Published: November 2023

AbstractExtensive aortic aneurysms represent a unique challenge necessitating interdisciplinary efforts for safe and effective treatment. Despite various adjunctive neuroprotective strategies, ischemic spinal cord injury remains a devastating complication. This article describes the implementation of collateral network near-infrared spectroscopy as the first noninvasive spinal cord monitoring modality in the setting of extensive open and endovascular aortic repair, from early conceptualization to clinical utilization. Potential capabilities and remaining uncertainties based on current evidence are outlined and discussed.
“Natural” History of Operated Type A Aortic Dissection
Authors: Danzi Gian B. , Carrozza Alberto , Frattini Silvia 
Published: November 2023

AbstractWe describe the case of a 66-year-old gentleman with a previous replacement of the ascending aorta for an acute Type A aortic dissection who did not attend any scheduled follow-up visit. Seventeen years later, he presented to our institution with severe aortic regurgitation and with a giant aneurysmal dilation of the abdominal aorta.
Secondary Endovascular Conversions for Failed Open Repair
Authors: Melo Ryan Gouveia e , Spath Paolo , Stana Jan , Prendes Carlota F. , Stavroulakis Konstantinous , Rantner Barbara , Pichlmaier Maximilian , Tsilimparis Nikolaos 
Published: November 2023

AbstractLate aortic and graft-related complications after open aortic repair are not infrequent and a significant number of them are missed, diagnosed at a very late stage, or present as urgent complications such as aortic rupture or aorto-enteric fistula. Once a late complication is diagnosed and reintervention is necessary, both open and endovascular strategies are possible. Open reintervention is complex and usually associated with very high rates of morbidity and mortality. Endovascular techniques may offer several solutions for these cases, which may be tailored to the patient and specific complication. In this review, we aim to summarize current indications, options, and strategies for endovascular salvage after failed or complicated open surgical repair.
Primary, Nonmidline, Extragonadal, Immature Teratoma of the Palm with Axillary Nodal Metastasis: A Rare Case Report and Review of Literature
Authors: Balachandran Reshma R. , Adhvaryu Vishesha V. , Joshi Shalaka , Ramadwar Mukta , Bindu Ameya , Nayak Prakash 
Published: November 2023

AbstractPrimary, nonmidline, extragonadal germ cell tumors are rare. Numerous hypotheses have been proposed regarding their origin. There is lack of consensus regarding their appropriate management. We report a case of an immature teratoma arising of the left palm. A 36-year-old lady presented with a recurrent left palm swelling. Histopathological features with immunohistochemical evaluation were characteristic of an immature teratoma. Alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) were elevated. She received preoperative chemotherapy with bleomycin, etoposide, cisplatin (BEP) followed by wide excision of the palm lesion and reconstruction with free latissimus dorsi flap. Postoperatively, two more cycles of BEP were given. Eight months later, she presented with large left axillary mass which showed metastatic deposits of immature teratoma on trucut biopsy. AFP and LDH were mildly elevated. On staging fluorodeoxyglucose-positron emission tomography (FDG-PET), there were no distant metastases. She received two cycles of vinblastine, ifosfamide, and cisplatin (VeIP). Postchemotherapy FDG-PET showed good metabolic response; however, the mass remained morphologically stable. Complete resection of the axillary mass was achieved with resection of a segment of axillary vein and end-to-end reanastomosis. At 12 months of follow-up the patient is disease free. This is the first report of axillary metastases in immature teratoma of the upper extremity. Axilla is a possible site of lymph node metastases in extremity teratoma. Primary extragonadal germ cell tumor should be managed with complete surgical resection and chemotherapy.
Brain Tumors in Adolescents and Young Adults: A Review
Authors: Rousseau Julien , Bennett Julie , Lim-Fat Mary Jane 
Published: November 2023

AbstractBrain tumors account for the majority of cancer-related deaths in adolescents and young adults (AYAs), defined as individuals aged 15 to 39. AYAs constitute a distinct population in which both pediatric- and adult-type central nervous system (CNS) tumors can be observed. Clinical manifestations vary depending on tumor location and often include headaches, seizures, focal neurological deficits, and signs of increased intracranial pressure. With the publication of the updated World Health Organization CNS tumor classification in 2021, diagnoses have been redefined to emphasize key molecular alterations. Gliomas represent the majority of malignant brain tumors in this age group. Glioneuronal and neuronal tumors are associated with longstanding refractory epilepsy. The classification of ependymomas and medulloblastomas has been refined, enabling better identification of low-risk tumors that could benefit from treatment de-escalation strategies. Owing to their midline location, germ cell tumors often present with oculomotor and visual alterations as well as endocrinopathies. The management of CNS tumors in AYA is often extrapolated from pediatric and adult guidelines, and generally consists of a combination of surgical resection, radiation therapy, and systemic therapy. Ongoing research is investigating multiple agents targeting molecular alterations, including isocitrate dehydrogenase inhibitors, SHH pathway inhibitors, and BRAF inhibitors. AYA patients with CNS tumors should be managed by multidisciplinary teams and counselled regarding fertility preservation, psychosocial comorbidities, and risks of long-term comorbidities. There is a need for further efforts to design clinical trials targeting CNS tumors in the AYA population.
The use of a fitness app for customer recommendation: linear models and qualitative comparative analysis
Authors: García-Pascual Fernando , Valcarce-Torrente Manel , Calabuig Ferran , García-Fernández Jerónimo 
Published: November 2023

AbstractThe use of technology within sports services has become an important field of study. Currently, the vast majority of sports services offer their users mobile applications to facilitate aspects such as communication and information. Within fitness centres, these mobile applications have become key elements to keep users informed and to reinforce behaviours such as loyalty towards the service. This study analyses the influence of mobile applications used in fitness centres on users’ recommendations of the app. Two methodologies were used to measure users’ perceptions: linear models and qualitative comparative analysis. The main results show that certain dimensions of the Mobile App Rating Scale (MARS) have a strong influence on users’ future app recommendations as well as the influence of users’ gender and age. It is important for managers of these sports services to implement technologies that provide two-way communication with users and therefore facilitate positive app recommendations. Furthermore, analysing the data using these two methodologies offers researchers a more detailed examination to better understand customers’ perceptions and, consequently, to establish more precise actions within the service.
Intersemiotic interpretation of demonstrative that in modern TV series
Authors: Zhou Nana 
Published: November 2023

AbstractThe study aims to illustrate that the intersemiotic interpretation of demonstrative that can eliminate the deictic indeterminacy of that in implying the proximity especially when what that identifies is not adequately interpreted in the linguistic expressions. To instantiate this viewpoint, the data are drawn from the modern TV series, annotated by the annotation tool ELAN 6.3, and analyzed by a qualitative method in terms of the complementarity of a visual deictic to demonstrative that, the explicit and implicit demonstrative that, as well as the transformation of that into this. It was found that the visual deictics, such as the arrow, the curve line, the cross, the gaze and other visual images, could eliminate the deictic ambiguity of demonstrative that when that was used to identify an element. The explicit and implicit that sheds light on the deictic divergency of the visual proximity from the linguistic one in multimodal discourse. A visual deictic may force the linguistic deictic that to transform into this by its reappearance. The results do not totally deny the traditional uses of demonstrative that, but expand its deictic function to present the multi-dimensional and dynamic world.
Promoting Alcohol Reduction in Non-Treatment Seeking parents (PAReNTS): a pilot feasibility cluster randomized controlled trial of brief alcohol interventions with parents in contact with child safeguarding services
Authors: McGovern Ruth , Smart Deborah , Alderson Hayley , Fouweather Tony , Kaner Eileen 
Published: November 2023

Abstract
Many parents who come into contact with early help and children’s social care services are risky drinkers. This study aimed to investigate the feasibility and acceptability of conducting a trial of brief alcohol interventions within this setting. We conducted a three-arm pilot feasibility cluster randomised controlled trial in the North-East of England. The additive interventions were: i) screening and a healthy lifestyle leaflet (control); ii) brief advice; iii) extended brief intervention. The trial was later reduced to two-arm due to the extended brief intervention being infeasible. Of the 1769 parents that were approached, 429 consented to be screened (24%), the majority were eligible to participate (n = 415; 97%), 147 of which (35%) scored ≥5 on the AUDIT-C screening tool. There were 108 parents (74%) who consented to participate in the trial (n = 50 control; n = 58 brief advice). Follow-up rates at 6 and 12-months were 61% and 43%. The TLFB30 was found to be a suitable tool to measure the primary outcome of heavy episodic drinking. Qualitative data showed that parents and practitioners largely found trial procedures to be acceptable, however, care should be taken when discussing alcohol risk with parents in this setting. Most of the a-priori success criteria were met in this pilot feasibility trial. The findings suggest that it may be feasible to conduct a two-arm randomised controlled trial of brief alcohol interventions to parents in contact with early help and social care. The TLFB30 was found to be a suitable tool to measure the primary outcome of heavy episodic drinking.
Limited Incision Facelifts: A Contemporary Review of Approaches and Complications
Authors: Amador Ricardo O , Hamaguchi Ryoko , Bartlett Richard A , Sinha Indranil 
Published: November 2023

Abstract
Limited incision facelifts (LIFs) have gained popularity as an alternative to traditional facelift procedures. While surgical techniques vary, these approaches share a common goal: to rejuvenate the face while minimizing scar visibility. Previous studies also suggest that the reduced tissue dissection in LIFs can lead to decreased postoperative swelling, shorter recovery periods, and fewer complications. In this systematic review we delved into the literature on LIFs, shedding light on the various surgical approaches and their respective safety profiles. A systematic review was conducted by independent evaluators who followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A random-effects model was utilized to summarize complications data, and meta-regressions were conducted to analyze associations with operative variables. The analysis encompassed a total of 20 articles, comprising data from 4451 patients. The vast majority (84%) of these patients underwent either local wide-awake surgery or conscious sedation, while the remaining 16% underwent general anesthesia. Our analysis revealed an overall complication frequency of 3.2%, with hematoma being the most common complication (2%), followed by temporary nerve injury (0.2%), and skin necrosis or wounds (0.06%). Notably, hematomas rarely required operating room interventions. Use of drains or tissue sealants was associated with an 86% decrease in complications. Limited incision facelifts can be performed with a low complication rate, utilizing a variety of techniques. Utilization of tissue sealants and drains may limit hematoma formation, which is the most common complication.
SMG: self-supervised masked graph learning for cancer gene identification
Authors: Cui Yan , Wang Zhikang , Wang Xiaoyu , Zhang Yiwen , Zhang Ying , Pan Tong , Zhang Zhe , Li Shanshan , Guo Yuming , Akutsu Tatsuya , Song Jiangning 
Published: November 2023

Abstract
Cancer genomics is dedicated to elucidating the genes and pathways that contribute to cancer progression and development. Identifying cancer genes (CGs) associated with the initiation and progression of cancer is critical for characterization of molecular-level mechanism in cancer research. In recent years, the growing availability of high-throughput molecular data and advancements in deep learning technologies has enabled the modelling of complex interactions and topological information within genomic data. Nevertheless, because of the limited labelled data, pinpointing CGs from a multitude of potential mutations remains an exceptionally challenging task. To address this, we propose a novel deep learning framework, termed self-supervised masked graph learning (SMG), which comprises SMG reconstruction (pretext task) and task-specific fine-tuning (downstream task). In the pretext task, the nodes of multi-omic featured protein–protein interaction (PPI) networks are randomly substituted with a defined mask token. The PPI networks are then reconstructed using the graph neural network (GNN)-based autoencoder, which explores the node correlations in a self-prediction manner. In the downstream tasks, the pre-trained GNN encoder embeds the input networks into feature graphs, whereas a task-specific layer proceeds with the final prediction. To assess the performance of the proposed SMG method, benchmarking experiments are performed on three node-level tasks (identification of CGs, essential genes and healthy driver genes) and one graph-level task (identification of disease subnetwork) across eight PPI networks. Benchmarking experiments and performance comparison with existing state-of-the-art methods demonstrate the superiority of SMG on multi-omic feature engineering.
Phylogeny, ecology, and evolution of mycophagous Drosophilidae (Diptera)
Authors: Kimura Masahito T , Tuno Nobuko 
Published: November 2023

Abstract
A number of species and taxa of Drosophilidae (Diptera) are used as model clades in various fields of biology, but our knowledge on their ecology and co-evolution (e.g. how their populations are regulated and how they interact with host organisms, enemies, and competitors) is still limited. According to studies on their host use, their primary larval resources are fruits, flowers, plant leaves and stems, tree sap, and fungal fruiting bodies, and most species are specialized to one of these resources. Among these species, those exploiting fungal fruiting bodies (i.e. mycophagous species) have been relatively well studied for their ecology, because their resources are commonly found in the field, hence their interactions with enemies and competitors can be assessed rather easily. So far, a review article has been published on their ecology in 1990. Since then, remarkable advances have been achieved on their taxonomy, phylogeny, diversity, and interactions with parasites, parasitoids, and competitors. This article reviews literature mainly published since 1990 to provide a basis for the future study of their ecology and evolution.
Bistable perception, precision and neuromodulation
Authors: Novicky Filip , Parr Thomas , Friston Karl , Mirza Muammer Berk , Sajid Noor 
Published: November 2023

Abstract
Bistable perception follows from observing a static, ambiguous, (visual) stimulus with two possible interpretations. Here, we present an active (Bayesian) inference account of bistable perception and posit that perceptual transitions between different interpretations (i.e. inferences) of the same stimulus ensue from specific eye movements that shift the focus to a different visual feature. Formally, these inferences are a consequence of precision control that determines how confident beliefs are and change the frequency with which one can perceive—and alternate between—two distinct percepts. We hypothesized that there are multiple, but distinct, ways in which precision modulation can interact to give rise to a similar frequency of bistable perception. We validated this using numerical simulations of the Necker cube paradigm and demonstrate the multiple routes that underwrite the frequency of perceptual alternation. Our results provide an (enactive) computational account of the intricate precision balance underwriting bistable perception. Importantly, these precision parameters can be considered the computational homologs of particular neurotransmitters—i.e. acetylcholine, noradrenaline, dopamine—that have been previously implicated in controlling bistable perception, providing a computational link between the neurochemistry and perception.
Divergent electroencephalogram resting-state functional network alterations in subgroups of autism spectrum disorder: a symptom-based clustering analysis
Authors: Zhu Gang , Li Yuhang , Wan Lin , Sun Chunhua , Liu Xinting , Zhang Jing , Liang Yan , Liu Guoyin , Yan Huimin , Li Rihui , Yang Guang 
Published: November 2023

Abstract
Autism spectrum disorder (ASD) is characterized by etiological and phenotypic heterogeneity. Despite efforts to categorize ASD into subtypes, research on specific functional connectivity changes within ASD subgroups based on clinical presentations is limited. This study proposed a symptom-based clustering approach to identify subgroups of ASD based on multiple clinical rating scales and investigate their distinct Electroencephalogram (EEG) functional connectivity patterns. Eyes-opened resting-state EEG data were collected from 72 children with ASD and 63 typically developing (TD) children. A data-driven clustering approach based on Social Responsiveness Scales-Second Edition and Vinland-3 scores was used to identify subgroups. EEG functional connectivity and topological characteristics in four frequency bands were assessed. Two subgroups were identified: mild ASD (mASD, n = 37) and severe ASD (sASD, n = 35). Compared to TD, mASD showed increased functional connectivity in the beta band, while sASD exhibited decreased connectivity in the alpha band. Significant between-group differences in global and regional topological abnormalities were found in both alpha and beta bands. The proposed symptom-based clustering approach revealed the divergent functional connectivity patterns in the ASD subgroups that was not observed in typical ASD studies. Our study thus provides a new perspective to address the heterogeneity in ASD research.
Feedback-related brain activity in individual decision: evidence from a gambling EEG study
Authors: Jiang Lin , Wang Guangying , Zhang Silai , Ye Jiayu , He Runyang , Chen Baodan , Si Yajing , Yao Dezhong , Yu Jing , Wan Feng , Xu Peng , Yu Liang , Li Fali 
Published: November 2023

Abstract
In this study, based on scalp electroencephalogram (EEG), we conducted cortical source localization and functional network analyses to investigate the underlying mechanism explaining the decision processes when individuals anticipate maximizing gambling benefits, particularly in situations where the decision outcomes are inconsistent with the profit goals. The findings shed light on the feedback monitoring process, wherein incongruity between outcomes and gambling goals triggers a more pronounced medial frontal negativity and activates the frontal lobe. Moreover, long-range theta connectivity is implicated in processing surprise and uncertainty caused by inconsistent feedback conditions, while middle-range delta coupling reflects a more intricate evaluation of feedback outcomes, which subsequently modifies individual decision-making for optimizing future rewards. Collectively, these findings deepen our comprehension of decision-making under circumstances where the profit goals are compromised by decision outcomes and provide electrophysiological evidence supporting adaptive adjustments in individual decision strategies to achieve maximum benefit.