bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSMENT OF THE PRESENT BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN IN CHRONIC SUPPURATIVE OTITIS MEDIA IN SANA’A, YEMEN
Authors: Al-Khamesy Khaled Saad Abdulrahman , Al-Shamahy Hassan Abdulwahab 
Published: November 2023

Background and objectives: The drainage of pus from the ear through a ruptured tympanic membrane that lasts longer than 12 weeks is known as chronic suppurative otitis media (CSOM). The purpose of the study was to ascertain the microbiological profile of middle ear chronic inflammation (CSOM) and the isolates' susceptibility to locally accessible antibiotics.
Subjects and methods: Total 111 ear swab samples from patients with clinically confirmed active CSOM were used in this cross-sectional investigation. Following a standard protocol, ear swabs were cultured to identify microbes. A modified Kirby-Bauer disk diffusion method was used to test antibiotic susceptibility, and the Clinical Laboratory Standards Institute's guidelines were followed to determine the diameter of the zone of inhibition.
Results: During two years, 111 patients with chronic suppurative otitis media were collected from January 2020 to the end of December 2022. Most of the patients were males (63.96%) while females were 36.04%. 36.04% of the total patients were in the ≤10-year group, and 29.7% were in the ≥46-year group while the other age groups were less frequent. Microbial growth was seen in 91.9% of samples, but 7.2% of samples did not. Among the samples with growth, 71.2% were monomicrobial, 12.6% were polymicrobial, and 9% had mixed growth with more than three microorganisms. The most frequently isolated bacteria were Pseudomonas aeruginosa (34.95%) followed by Staphylococcus aureus (14.6%) and Klebsiella spp. (9.8%). The antibiotics most sensitive against P. aeruginosa were cefepime (97.7%), meropenem (95.3%), piperacillin-tazobactam (95.3%), and ciprofloxacin (93%). Staphylococcus aureus showed the highest sensitivity to rifampin (100%) and fusidic acid (88.9%).
Conclusion: In the bacteriological profile of CSOM, P. aeruginosa, S aureus, Klebsiella spp., and Acinetobacter spp. are highly prevalent. The distribution of CSOM varies depending on the age group. The antibiotic susceptibility pattern of the bacterial isolates decreased. It is critical to review antibiotic prescriptions based on susceptibility and to be informed of the current trend in bacteriological profiles.

Peer Review History:
Received: 8 August 2023; Revised: 19 October; Accepted: 2 November, Available online: 15 November 2023
Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com
CONFORMATIONAL STUDY OF MOLECULES IN A BIOLOGICAL ENVIRONMENT, DESIGN OF INHIBITORS OF HUMAN AMINOPEPTIDASE M1 IMPLICATED IN CANCER THERAPY
Authors: Soro Issouf , N’Guessan Hermann , Abou Akoun , N’Guessan Raymond Kre , Megnassan Eugene 
Published: November 2023

Objective: A novel subnanomolar anticancer hydroxamic acid containing drug candidates, inhibitors of human M1 aminopeptidase (APN) a recent validated target and has reached the predicted subnanomolar range of inhibitory potency.
Methods: A quantitative structure activity relationships (QSAR) complexation model has been developed from a compounds of 37 hydroxamic acid derivatives (AHD1-37 as training set, TS) to establish a linear correlation between the calculated relative Gibbs free energies (GFE: ΔΔGcom) of APN-AHDx complex formation and the experimental inhibition potency (Kiexp). The predictive power of the QSAR model was then validated first with 9 other AHDs not included in the TS and thereafter with the generation of a 3D-QSAR-PH4 pharmacophore (PH4) model to screen the AHD chemical subspace built as a virtual combinatorial library of more than 58,644 AHD analogs). Finally the best PH4 hits were evaluated with the initial QSAR model for predicted potency (Kipre) and pharmacokinetic profile.
Results: The QSAR model linear correlation equation: pKiexp=-0.1901×∆∆Gcom + 8.2886 , R2=0.94, the subsequent PH4 model linear correlation between experiment and PH4-estimated Ki: pKiexp=1.0006× pKipre + 0.0028, R2=0.79 documents the high predictive power of this approach. Finally the screening of the virtual library of AHD analogs yielded 95 orally bioavailable candidates the best reaching a predicted potency (Kipre) of 50 pM and displaying favorable pharmacokinetic profile.
Conclusion: The combined use of molecular modeling (QSAR) and in silico PH4-based screening of the hypothetical combinatorial library has resulted in proposed and predicted potent anticancer candidates with a suitable pharmacokinetic profile.

Peer Review History:
Received: 3 August 2023; Revised: 12 September; Accepted: 25 October, Available online: 15 November 2023
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 7.0/10
Average Peer review marks at publication stage: 9.0/10
Reviewers:
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Prof. Dr. A. Hakan AKTAŞ, Süleyman Demirel University, Faculty of Science and Art, Department of Chemistry, Isparta-Turkey, hakanaktas@sdu.edu.tr
Analisis Hambatan Inisiatif Industri 4.0 Pada Rantai Pasokan Industri di Indonesia
Authors: Ariyanti Fransisca Dini , Nasution Januar , Mahardini Karunia Agung 
Published: November 2023

Di negara berkembang, khususnya Indonesia, Industri 4.0 relatif masih baru. Karena inisiatif dari Industri 4.0 dapat mengubah cara produk dirancang, diproduksi, dikirim, dan dibuang, dan mempengaruhi seluruh sistem bisnis. Tujuan penelitian ini, adalah untuk meneliti hambatan utama penerapan Industri 4.0 untuk mencapai arah pengelolaan dalam rantai pasokan. Sehingga dapat di susun daftar prioritas atas hambatan utama yang diidentifikasi. Dalam penelitian ini di identifikasi delapan belas hambatan inisiatif Industri 4.0, selanjutnya diklasifikasikan pada empat kriteria utama yaitu: Organisasi (O), Teknologi (T), Strategi (S), Legal & Etika (L). Untuk mendapatkan umpan balik dari ahli industry di Indonesia, digunakan survei secara online kepada praktisi industry dan akademisi. Metodenya kombinasi dari EFA, Explanatory Factor Analysis, dan rangking prioritas dengan ANP Analytic Network Process. Hasil prioritas adalah hambatan Organisasi paling penting, diikuti hambatan Teknologi sebagai peringkat kedua, lalu hambatan Strategi sebagai peringkat ketiga, dan hambatan Legal & etika sebagai peringkat terakhir.
References Supporting Recommendations in Obstetrical Green Top Guidelines: an Overview
Authors: Soylu Halime Meryem , Mendez-Figueroa Hector , Chauhan Suneet , Huntley Benjamin 
Published: November 2023

n/a per BJOG Research Letter submission guidelines. + happy to submit an
abstract if needed.
https://obgyn.onlinelibrary.wiley.com/hub/journal/14710528/preparing-your-manuscripts
Customer Analytics in Performance Measurement and Reporting Systems
Authors: Bonacchi Massimiliano , Perego Paolo 
Published: November 2023

SYNOPSIS
This study examines how firms deploy customer analytics in their performance measurement and reporting systems. Firstly, we synthesize insights from the literature on customer analytics in accounting and marketing and conduct interviews with experts in the field. We then present the results of an online survey conducted among a sample of subscription-based firms known for their early adoption of customer analytics. Our findings reveal that the use of customer analytics varies significantly by metric type, with traditional indicators (e.g., number of customers) showing higher levels of integration compared with more advanced metrics, such as customer lifetime value and customer equity. The extent of adoption in performance measurement and reporting systems appears to depend on the ability of a firm to fit customer analytics into its organizational architecture. We conclude by identifying research avenues reflecting current trends that will likely shape the emerging literature on customer analytics.
Auditors’ Remote Work Experiences during the Early Days of the COVID-19 Pandemic and Implications Going Forward
Authors: Jenkins J. Gregory , Loraas Tina M. , Stanley Jonathan D. 
Published: November 2023

SYNOPSIS
We document auditors’ remote work experiences during the early days of the COVID-19 pandemic. We surveyed U.S. auditors to explore their communications with engagement team members and clients and to understand the perceived benefits and challenges of working remotely. Our findings reveal that not all auditors fared equally during remote work. We find that remote work did not generally diminish the initiation or frequency of communication with clients or audit team members (including socially oriented communication); however, the effectiveness of communication with colleagues and/or clients was the most frequently cited challenge. Clients were perceived as being less cooperative and responsive to information requests (especially by less experienced auditors). On the other hand, remote work did provide benefits including no commute, enhanced work/life balance (especially for more experienced auditors), and greater schedule flexibility. We discuss implications of our results as firms continue allowing auditors to work remotely and under hybrid arrangements.
Morristown Memorial Hospital: The Nonprofit Property Tax Exemption Debate
Authors: McGowan Michele M. , Lohin Joseph R. , Williams Barry H. 
Published: November 2023

ABSTRACT
This case highlights nonprofit hospital organizations’ changing roles and relationships with their tax-exempt status and the communities they serve. Historically, nonprofit hospitals justified tax exemption by meeting community health needs but have evolved into extensive partnerships with for-profit organizations to obtain the resources necessary to provide state-of-the-art care. Unfortunately, these arrangements have raised issues regarding tax-exempt status, making nonprofit hospitals an increasing target of property tax exemption challenges for cash-strapped municipalities. This was the case when the property tax exemption of Morristown Memorial Hospital was called into question. The New Jersey Tax Court pointed to a complex structure in which nonprofit and for-profit interests were inextricably intertwined. It is held that, if modern nonprofit hospitals operate like this, they are essentially legal fiction. Students assess whether the Hospital satisfies the criteria for property tax exemption and debate the legitimacy of tax exemption given the changing nature of nonprofit hospital operations.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: H22; H71; H75; I18; K34; L31.
Pengembangan Instrumen Pengukuran Prokrastinasi Siswa Sekolah Menengah Pertama
Authors: Aning Ketut Sudi , Suranata Kadek , Dwiarwati Kadek Ari 
Published: November 2023

Penelitian ini bertujuan untuk mengembangkan alat ukur dan menguji kelayakannya sehingga menghasilkan instrumen yang valid dan reliabel dalam megukur tingkat prokrastinasi<em> </em>pada siswa Sekolah Menengah Pertama (SMP). penelitian ini di susun dengan menggunakan prosedur model penelitia pengembangan (<em>Research &amp; Development</em>) dengan model pengembangan oleh Thiagarajan yaitu 4D (four-D): <em>define</em> (pendefinisian), <em>design</em> (perancangan), <em>develop </em>(pengembangan), dan <em>disseminate</em> (penyebarluasan).. Subyek dalam penelitian pengembangan ini meliputi 5 pakar, yakni 3 dosen bimbingan konseling FIP Undiksha dan 2 guru bimbingan konseling di SMP Laboratorium dan SMP N 1 Banjar . Metode analisis data yang digunakan adalah uji validitas isi, uji validitas empiris dan uji reliabilitas. Pada uji validitas isi menggunakan rumus Formula Lawshe (1975), yaitu <em>Content Validity Ratio</em> (CVR) dan <em>Content Validity Indeks</em> (CVI) dengan hasil ∑CVR = 40 dan CVI 1 . Untuk uji validitas empiris, diperoleh melalui hasil uji coba instrumen kepada responden sebanyak 200 siswa.Diketahui bahwa hasil uji validitas empiris yaitu rhit &gt; rtab dengan rumus <em>pearson product moment</em> melalui aplikasi SPSS, yang berarti semua butir instrumen memiliki status yang valid atau terpakai. Lalu pada uji reliabilitas, hasil perhitungan menunjukkan koefisien reliabilitas instrumen pengukuran prokrastinasi siswa Sekolah Menengah Pertama (SMP) sebesar 0.938 dengan responden sebanyak 200 siswa, apabila dibandingkan dengan rtab sebesar 0.244 pada taraf signifikansi 0.05% maka ralpa ≥ rtab sehingga instrumen dapat dikatakan reliabel.<em></em><p> </p><p class="Abstrak"> </p>
Problematika multikultural dalam pelakasanan layanan konseling kelompok
Authors: Kartikasari Wenny Audina , Suhaili Neviyarni , Netrawati Netrawati 
Published: November 2023

Konselor harus mampu mengetahui kejadian-kejadian klien yang memegang ajaran berbeda-beda. Keadaan yang terdapat pada klien itu juga terjadi depan guru, namun karena kualitas guru seperti helper, maka guru harus memegang pengetahuan diri. Tidak mudah bagi guru untuk mengerjakan bagian tersebut, kepada itu guru harus menaruh pendekatan- pendekatan lintas kultur. Dalam aktivitas konseling, seorang guru mesti mengamati kebudayaan yang terdapat depan kliennya demi memperlancar usaha konseling tersebut, latar belakang guru yang tidak bisa membentuk dirinya dengan kultur yang dimiliki oleh klien maka peluang besar mudah menghalangi terjadinya interaksi. tujuan penelitian ini upaya pemahaman yang dimiliki siswa dalam berbagai perbdaan perbedaan budaya yang milikinya dengan melihat dari beberapa aspek 1) Aspek pemhaman mengenai konseling multikulral budaya 2) aspek tentang kesadaran dalam pennerimaan baik tidaknya dengan wujud prasangka subjek terhadap budaya dari masing masing siswa. 3) Aspek bahasa yang digunakan dalam kegiatan kelompok berlangsung. Metode Penelitian ini menggunakan jenis penelitian studi referensi (<em>Library Reseach</em>). <em>Libarary review</em> ini berisikan ulasan, rangkuman dan pemikiran tentang Permasalahan konseling multikultural di masyrakat. Studi Literatur <em>(literature review)</em> merupakan penelitian yang dilakukan oleh peneliti dengan mengumpulkan sejumlah buku buku, majalah yang berkaitan dengan masalah dan tujuan penelitian. Teknik ini dilakukan dengan tujuan untuk mengungkapkan berbagai teori-teori yang relevan dengan permasalahan yang sedang dihadapi/diteliti sebagai bahan rujukan dalam pembahasan hasil penelitian.
Aplikasi Mesin Pengiris Otomatis Pada Proses Produksi Keripik Singkong UMKM Swakarya Di Desa Rulung Sari, Lampung Selatan
Authors: Utami Herti , Br Ginting Simparmin , Wardono Herry 
Published: November 2023

Kelompok UMKM Swakarya yang berlokasi di Desa Rulung Sari, Lampung Selatan adalah industri skala rumah tangga yang memiliki usaha memproduksi berbagai olahan keripik. UMKM Swakarya ini kegiatannya dimulai sejak tahun 2020. Pada saat itu berawal dari terjadinya kelesuan perekonomian, dikarenakan pandemi Covid 19, sehingga timbul ide untuk menjual produk olahan makanan dengan bahan yang mudah didapat di sekitar tempat tinggal mereka yaitu keripik singkong. Permasalahan yang ada di mitra UMKM Swakarya ini adalah waktu lama untuk mengiris bahan baku singkong, alat manual, hasil irisan tidak seragam. Keterbatasan ini juga membuat produk kualitasnya kurang baik. Tim Unila memberikan solusi dengan memberikan bantuan alat, pelatihan dan praktek menggunakan alat teknologi tepat guna dengan.mesin pengiris otomatis untuk bahan keripik agar pekerjaan menjadi praktis, mudah dan efisien serta hasil irisan lebih baik. Dengan mesin pengiris otomatis ini produksi mitra dapat berkembang lebih cepat. Pengirisan bahan baku singkong menjadi lebih efisien dibandingkan dengan pengirisan secara manual serta ketebalan keripik juga seragam. Diharapkan produk mitra meningkat secara kuantitas dan kualitasnya, peluang pemasaran lebih luas dan keuntungan mitra meningkat.
Kata kunci: mesin pengiris otomatis; keripik singkong; UMKM Swakarya
Interpretive legislation: comparative legal analysis
Authors: Yakymenko T.S. 
Published: November 2023

The author tries to show and explain a rather controversial legal mechanism called "authentic interpretation” of legal norms or "interpretative legislation”. By showing a comparative overview of different legal systems in Romano-German and Common law families, the author wants readers to guess whether interpreting laws (statutes, by-laws) with retrospective power is purely a judicial task. Why have we gotten used to thinking this way, and what in the separation of powers thesis excludes lawmakers from the authority to interpret their laws? At the same time, it is mentioned that the retrospectivity of laws does not necessarily violate the rule of law requirements when it is aimed at lacuna in laws or fixing technical defects in law.
Specific attention is paid to constitutional case law in different countries that classify the authority of abstract interpretation as a part of legislative power. Judicial deference as a doctrine developed by the US Supreme Court also described in this article. Having analyzed the experience of Slovenia, Croatia, Italy, Belgium, Australia and the USA, the author returns to Ukraine and shows some tendencies towards authentic interpretation, though not fully realized so far neither by the Supreme Court nor by Verkhovna Rada of Ukraine.
There are many questions on how justifiable it is to employ the authentic interpretation and whether it is instead an ultima ratio than regular practice. On the other hand, taking into account the current state of development and complexity of legislation in all spheres of social life, there is a need not only for legal monitoring, but also for preventive interpretive measures to eliminate ambiguity in judicial practice, correct judicial errors in interpretation and prevent undermining of legislation by courts due to incorrect interpretation.
Convention on International Cooperation in the Investigation and Prosecution of the Crime of Genocide, Crimes against Humanity, War Crimes, and other International Crimes: the focus of the provisions and challenges
Authors: Hloviuk I.V. 
Published: November 2023

The article is devoted to the analysis of the provisions of the 2023 Convention on International Cooperation in the Investigation and Prosecution of the Crime of Genocide, Crimes against Humanity, War Crimes, and other International Crimes. The analysis of the provisions of the Convention is important for assessing the capacity of existing mechanisms to respond to international crimes committed in Ukraine. Therefore, the purpose of the article was to assess the provisions of the Convention, its correlation with the legislation of Ukraine, in the aspect of prosecution those guilty of international crimes against Ukraine and the Ukrainian people.
The article examines in detail: the scope and purpose of the Convention; obligations of criminalization; obligation to establish jurisdiction; principle «aut dedere aut judicare»; areas of mutual legal assistance; provisions regarding victims.
It is indicated that the Convention is an important step in the development of prosecution mechanisms for war crimes. Its unique feature is the presence of norms of international criminal law, despite the name, which concerns only international cooperation, which is not at all characteristic of other conventions on mutual legal assistance. Unfortunately, however, some war crimes and crime of aggression will require additional notification of the application of the Convention, which again reduces its potential positive impact on prosecutions for international crimes.
The analysis of the provisions of the Convention allows us to reasonably assume that in the event of its ratification: there will be a need to improve the norms of the Criminal Code of Ukraine regarding the effect of the criminal law on persons and universal jurisdiction; will require updating the norms of the Criminal Procedure Code of Ukraine regarding the provision of international legal assistance; additions to the provisions of the Criminal Procedure Code of Ukraine regarding extradition in aspects of the «aut dedere aut judicare» principle will be required; will require verification on the issue of compliance of the Criminal Procedure Code of Ukraine with the Convention regarding the participation of victims in criminal proceedings. In addition, the issue of regulation of restitution, compensation and rehabilitation and other forms of compensation for victims of international crimes will need to be resolved.
The right to peace: modern approaches to legal understanding
Authors: Byelov D.M. , Suhan I.S. 
Published: November 2023

The article defines the right to peace in the context of the third generation of human rights, i.e. rights, the subject of which is society as a whole. It is determined that the right to peace is an international collective right, which is based on ensuring the prerequisites for a safe, stable, and dignified life of human societies away from the dangers and disasters of wars, as well as the consequences and dangers of armed conflicts, in the light of the basic requirements that arise from the idea of ensuring achieving security of human rights, non-violence, achieving development, environmental protection and other elements that cannot be separated from the right to peace.
The author lists the characteristics of the right to peace as a third-generation right, namely: the international nature of the organization, collectivity, protection from the provisions of international law, and subsidiarity compared to the rights of other generations.
The essential characteristics of the right to peace are determined, in particular the interrelationship of peace with other fundamental human rights, as well as the interdependence of all states in the aspect of ensuring the right to peace. The author proves the thesis that the right to peace is the duty of all states because the existence of a conflict between two parties determines the disturbance of peace and stability beyond the borders of the conflicting parties.
The means of ensuring the right to peace and measures taken by the United Nations to maintain and establish peace and security, i.e. effective and collective measures to prevent and eliminate threats to peace and to achieve it by peaceful means and in accordance with the principles of justice and international law are described. The characteristics of peacekeeping operations and monitoring missions, the latter of which took place for settlement between Ukraine and the Russian Federation, are given.