bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motor nerve detection and functional rehabilitation for Athlete based on functional near-infrared spectroscopy imaging
Authors: Liu Dongdong 
Published: January 2024

Abstract

With the rapid development of society and economy, people's living pressure is constantly increasing, and some diseases such as motor neuron disease (ALS) are troubling people. However, the accuracy of diagnosing ALS is still relatively low. Therefore, this article specifically designs a motor nerve detection system and a functional rehabilitation system based on functional infrared spectroscopy. Firstly, this article provides an in-depth explanation of the principles of functional infrared spectroscopy imaging technology, and summarizes the principles and characteristics of functional near-infrared spectroscopy imaging technology. The research process mainly utilizes functional near-infrared spectroscopy to evaluate patients themselves, and then conducts subsequent experiments to accurately analyze the sensitivity and differences of functional near-infrared spectroscopy (FNIRS) parameters for different difficulties. The research results indicate that the FNIRS signal can make patients more sensitive. Within the specified range, the HbO (oxygen hemoglobin) and tHb (total hemoglobin) levels of patients will change with the difficulty of the task, and there will be a downward trend after the difficulty exceeds a specific value. Therefore, the imaging technology based on functional infrared spectroscopy proposed in this article achieves the design of a system for motor nerve detection and functional rehabilitation, and verifies the effectiveness of this system.
Quantitative Characteristics and Influencing Factors of Tibetan Buddhist Religious Space with Monasteries as the Carrier: A Case Study of U-Tsang, China
Authors: Fang Subin , Zhao Yaolong , Liu Xinxin , Yang Yao 
Published: January 2024

Abstract
Tibetan Buddhism has an inseparable connection with the spatial characteristics, development process, and human-natural environment of the Tibetan Plateau. This paper takes monasteries as carriers of Tibetan Buddhist culture in U-Tsang region which is one of the traditional geographical units of Tibet. Using geospatial analysis methods, this study explores the spatial quantification characteristics of Tibetan Buddhist monasteries and qualitatively and quantitatively analyzes the factors that influence the spatial distribution of monasteries. The results indicate that: (1) Political activities of human society influence the pattern of political power. Under the unique context of Tibetan theocracy system, the scope of political authority has a significant influence and affects the religious spatial pattern in the U-Tsang region throughout history. The distribution of monasteries in the U-Tsang region shows significant spatial differences at three sub-regional scales. (2) The religious spatial pattern in the U-Tsang is the result of the diverse interaction of human-natural factors. The results indirectly endorse that religious space is an inevitable product of the interaction between humans and the environment. (3) The religious spatial distribution patterns in the three major Tibetan regions have distinct characteristics, closely related to the superior conditions of their respective historical and geographical environments.
Oceanic Maintenance of Atmospheric Blocking in Wintertime in the North Atlantic
Authors: Mathews Jamie , Czaja Arnaud 
Published: January 2024

Abstract
The connection between atmospheric blocking over the North Atlantic and the diabatic influence of the Gulf Stream is investigated using potential vorticity and moist potential vorticity diagnostics in the ERA5 reanalysis data set during wintertime (1979 - 2020). In line with previous research, the reliance atmospheric blocking has on turbulent heat fluxes over the Gulf Stream and its extension, for induction and maintenance, is shown to be significant. The air-sea heat flux generates negative potential vorticity air masses in the atmospheric boundary layer. These air masses subsequently contribute to the block's negative potential vorticity anomaly at upper levels through ascending motion in the warm conveyor belt. It is shown that the block's size and frequency partially depends on oceanic preconditioning via anomalous oceanic heat transport and heat content, prior to the blocking event, both of which allow for stronger turbulent heat fluxes. It is further hypothesized that the block feeds back positively on itself through the advection of cold dry air over the Gulf Stream, sustaining this air-sea interaction. This in turn decreases ocean heat content, eventually halting this air-sea interaction and severing the atmospheric block from its maintenance pathway.
A rare asymtomatic metallic foreign body retained in the subconjunctival space for over 50 years: A Case Report
Authors: Su Wenqi , Jiang Feng , Li Xing , He Tiangeng 
Published: January 2024

Abstract
Background Superficial foreign body present on the conjunctiva or cornea can be easily detected and removed, and may pose minimal harm if addressed promptly. In this report, we present a case with a metallic foreign body remained within the subconjunctival space for over 50 years without significant ocular complications.Case presentation: An 80-year-old woman complained of tearing and blurred vision in the left eye. Slit-lamp examination showed the presence of a tiny metallic foreign body within subconjunctival space and the cataract in the left eye. No further abnormal findings were observed in the fundus and extraocular components during the examination. After inquiring about the patient's history of trauma, it was revealed that over 50 years ago, the patient experienced an ocular injury from a shard of iron while working at a factory. Since the patient's strong desire to alleviate ocular discomfort, the subconjunctival foreign body was removed under topical anesthesia in the operating room. After a 1-month follow-up, the patient reported the complete relief of tearing symptoms.Conclusions In this case, there appears to be no severe consequences associated with the long-term retention of a subconjunctival metallic foreign body. Nonetheless, it is imperative to conduct meticulous patient evaluations and interventions to mitigate the potential risk of injury.
Ricci Soliton in Deformed C12-Manifolds
Authors: Delloum Adel 
Published: January 2024

Abstract
This study centers on the exploration of specific deformations applied to almost contact metric manifolds, preserving the intrinsic structure of C12-manifolds. Subsequently, our investigation delves into the realm of Ricci solitons within the context of C12-manifolds subjected to such deformations. A detailed analysis is undertaken to understand the behavior of Ricci solitons, particularly when the potential vector field exhibits pointwise collinearity with the Reeb vector field or is orthogonal to it.
Engineering Resilient Community Pharmacies: Exploring an Integrative Approach to Medication Safety
Authors: Chui Michelle A. , Berbakov Maria E. , Gilson Aaron M. , Stone Jamie A. , Lehnbom Elin C. , Hoffins Emily L. , II James H. Ford 
Published: January 2024

Abstract
Introduction: The increase of people with complex chronic health conditions is stressing the U.S. healthcare delivery system. Community pharmacies play a role in ensuring patients’ safe medication use for chronic care management, but their efforts are undermined by volatile work demands and other system barriers.
Methods: This study seeks to conceptualize, design, implement, and test a MedSafeMapTM for the community pharmacy setting to enhance pharmacists’ and technicians’ abilities to either avoid, or to quickly identify and recover from, medication errors before patient safety is endangered.
Discussion: The MedSafeMap is an innovative approach that will be used by pharmacists and pharmacy technicians to better navigate the complex tasks in the pharmacy, and to facilitate communication with both patients and clinicians, while safely providing medications to complex patients with chronic health conditions.
Prevalence of Fat-Soluble Vitamin Deficiency in Post Hepaticoportoenterostomy Biliary Atresia Patients
Authors: Srima Kornkanok , Tanatip Narumon , Damrongmanee Alisara , Ukarapol Nuthapong 
Published: January 2024

Abstract
Purpose
To primarily evaluate the prevalence of fat-soluble vitamin (FSV) deficiency in children with EHBA. The secondary objective was to explore any possible associated risk factors.
Methods
FSV deficiency was diagnosed if either 1) vitamin A level < 0.7 micromol/L, 2) serum 25-OH D < 20 ng/mL, 3) vitamin E to cholesterol ratio < 2.22 micromol/mmol, or 4) INR > 1.5 correctable with parenteral vitamin K administration.
Results
Thirty EHBA patients (13 males) with an average age of 7.9 years old were consecutively enrolled. The prevalence of at least one FSV deficiency was 36.7% (95% CI 18.4, 54.9), in which the most common one was vitamin A deficiency (36.7%), followed by the deficiency of vitamin D, E, and K, respectively. Univariate analysis showed statistically significant differences in hepatomegaly, albumin, total bilirubin, direct bilirubin, hemoglobin level, anemia for ages, ESR, CRP, BUN, creatinine level, and PELD score between those with and without any FSV deficiency.
Conclusion
Vitamin A deficiency was the most frequently observed. Adequate vitamin supplementation should be carefully reviewed to prevent its deficiency, particularly in EHBA patients with high PELD scores, potentially indicative of LT.
A Cost‒Benefit Analysis of AlternativeManagement Strategies for Red Deer in Denmark
Authors: Jensen Frank , Lundhede Thomas , Sunde Peter 
Published: January 2024

Abstract

In this paper, we conduct a cost‒benefit analysis (CBA) of alternative management strategies for red deer in Denmark: free harvest, trophy hunting, maximum harvest and natural demographic population compositions. To capture the effect of each strategy, we use a biological sex- and age-structured population model, and in the net benefit, we include meat values, recreational values, browsing damage costs and traffic damage costs. These values and costs are assumed to differ for the various sex and age classes of red deer. We show that the maximum harvest strategy leads to a reasonably high positive total net benefit, while the free harvest strategy yields a small positive net benefit. Furthermore, the trophy hunting strategy generate a high negative net benefit, while a small negative net benefit is obtained under the strategies with a natural demographic population composition.
JEL codes: D61; Q29; Q51
Open Innovation in Healthcare Ecosystem – a systematic review
Authors: Torab-Miandoab Amir , Samad-Soltani Taha , Rezaei-hachesu Peyman 
Published: January 2024

Abstract
Background: Several countries are facing significant troubles of health services, particularly rising prices. Innovative technologies and services are expected to help boost medical quality and cut costs. In this sense, there is a lack of innovative work in spite of a growing interest in open innovation and approaches that advocate for expanded cooperation among various actors in healthcare.
Objective: This paper describes the findings of a study concerning the commitment of the healthcare sector to open innovation.
Materials and methods: The search for literature focused on English-language papers to 12 January 2020. Based on the indicated criteria for inclusion, 29 articles were included.
Results: Results show that most experiments concentrate on the areas of pharmaceutical research (drug discovery) and health informatics (health information systems and infrastructures) that were brought out as concepts or applied as pilot and prototype.
Conclusions: The participation of the healthcare sector limited in open innovation, and more work is required with an emphasis how to get open innovation.
Molecular mechanisms of inhibition of cellular senescence
Authors: Khanalieva I. A. , Svechnikova E. V. 
Published: January 2024

Introduction. Advances in studying skin ageing processes have proven the importance of high-quality synthesis of type I and III collagen. Protein synthesis is a genetically conditioned process encoded by many genes. Mutations in these genes lead to disorders in this process. The skin ageing genes FLG, AQP3, COL1A1, MMP1, ELN correlate with certain skin morphotypes, and studying the variability of gene transformations opens up new vistas for predicting the development of signs of ageing at any age and, as a result, timely prevention of ageing problems.Aim. To evaluate the effect of skin ageing correction therapy based on the ageing protein expression and the type I and III collagen production according to genetically conditioned ageing variants.Materials and methods. Patients in the comparison groups who had the major signs of skin aging received correction therapy according to regimen 1 (SKINOPRO ACTIVE 8 mg/ml every 7 days) and regimen 2 (SKINOPRO FORTE 12 mg/ml every 7 days). Evaluation of the efficacy of therapy with hyaluronic acid, silica and zinc drugs was based on an analysis of the pathomorphological view of biopsy specimens and an immunohistochemical analysis of Ki-67, p53, AP-1, Collagen I, Collagen III, TGF-b, Klotho, calreticulin expression.Results. The results support the importance of identification of aberrations in genes encoding the skin collagen synthesis to personalize treatment methods for correcting signs of aging in patient with different morphotypes.Conclusion. The article presents interim results of a comparative analysis of methods for correcting involutional changes in the face and neck skin. The possibility of further clinical studies of pharmacological drugs used to correct the morphofunctional signs of aging of the face and neck skin using the presented test findings is discussed.
Justification for exogenous replacement of magnesium deficiency in women planning pregnancy: experienc of using the drug
Authors: Mezhevitinova E. A. , Iurova M. A. , Abakarova P. R. , Kepsha M. A. 
Published: January 2024

Introduction. During pregnancy, the body’s need for most micronutrients increases, and therefore timely detection and adequate correction of deficient conditions are justified, starting from the stage of pre-gravidar preparation.Objective. The purpose of the study is to present literature data on the role of magnesium in homeostasis and own experience of the effectiveness of the use of magnesium preparation.Materials and methods. A review of the literature for 2021–2023 in the databases was conducted in the databases PubMed (the National Library of Medicine), The Cochrane Library, as well as in scientific citation databases (Scopus, Web of Science) The experience of own application of the preparation containing magnesium lactate dihydrate (470 mg) is also presented + pyridoxine hydrochloride (5 mg).Result and discussion. The intake of magnesium into the human body with food is insufficient. Exogenous magnesium replenishment is clinically justified in isolated or associated with other conditions of established deficiency, primarily with intense emotional and physical exertion, sleep deprivation, as well as with emotional lability, palpitations, muscle fasciculations, with magnesium elimination due to iatrogenic exposure or increased demand, for example, gestational-conditioned. Regular use of Magne B6® has demonstrated its effectiveness in the treatment of symptoms of psychological daily stress (fatigue, irritability, deterioration of sleep quality) in women planning pregnancy.Conclusions. The results obtained appear to be important in terms of reducing the risks of clinical progression of somatic symptoms and potential gestational complications, as well as improving the quality of life of childbearing age women who are actively planning to implement their reproductive function.
Obstetric and perinatal outcomes after a new coronavirus infection in the first and second trimesters of pregnancy
Authors: Khvorostukhina N. F. , Sheveleva D. I. , Novichkov D. A. , Stepanova N. N. , Suvorova G. S. , Odnokozova O. S. , Akhmedova Yu. K. 
Published: January 2024

Introduction. The management of pregnant women in the conditions of the spread of a new coronavirus infection has become a priority task for doctors of all specialties, since it is with this pathology that an increase in the frequency of unfavorable gestation outcomes is currently associated.The aim of the study: to study obstetric and perinatal outcomes after a new coronavirus infection in the I and II trimesters of pregnancy.Objective. To study the features of the course of pregnancy, childbirth and perinatal outcomes in ICI, depending on the method of delivery.Materials and methods. A comparative study of the birth histories of women after coronavirus infection in 2021 was carried out. Group 1 (n = 26) consisted of patients with COVID-19 infection in the first trimester, group 2 (n = 30) – in the second trimester. The 3rd group is represented by relatively healthy women (n = 35). Statistical analysis was performed using the Statistica 7.0, SPSS 17 packages, as well as the statistical functions of MS Excel 2013.Results and discussion. The course of pregnancy after COVID-19 infection suffered in the first and second trimesters is associated with an increased risk of placental insufficiency (26.9 and 30%, respectively), the development of sympthoms of threatening termination (61.5 and 46.7%), anemia (38.5 and 43.3%), gestational hypertension (15.4 and 16.7%), bacterial vaginosis (19.2 and 20.0%), premature rupture of fetal membranes (34.6 and 16.7%), with the prevalence of urgent labor, but an increase in premature (13.3%) and operative labor (36.7%) with the manifestation of the disease in the second trimester. Newborns of mothers with COVID-19 infection are more often born in a state of asphyxia (65.4 and 53.3%). The structure of perinatal pathology is dominated by cerebral ischemia (42.3 and 40%), perinatal hypoxic damage to the central nervous system (19.2 and 23.3%), neonatal jaundice (11.5 and 23.3%), intrauterine pneumonia (15.4 and 10.0%), congenital malformations (7.7 and 30.0%; p1-2 = 0.04).Conclusion. The results of the study once again have confirmed the need for further study of the problem in order to find measures to reduce obstetric and perinatal complications in women after COVID-19 infection.
The use of BRAF-inhibitors as monotherapy and in combination with cytosine arabinoside and 2-chloro-2’deoxyadenosine in pediatric patients with different forms of Langerhans cell histiocytosis
Authors: Burtsev E. A. , Evseev D. A. , Gaziev I. R. , Lebedeva L. L. , Skobeev D. A. , Osipova D. S. , Bronin G. O. , Maschan M. A. 
Published: January 2024

Background. Langerhans cell histiocytosis (LCH) is a rare disease that occurs due to abnormal proliferation and expansion of myeloid precursors. The occurrence of mutations in genes that encode key kinases of MAPK-signaling pathway leads to its pathological activation and has been shown the cause of disease. Mutations in BRAF and MAP2K1 genes are the most frequent among LCH patients. The effectiveness of BRAF-inhibitors in LCH patients has been shown in numerous studies.The purpose of the study – analyze the experience of BRAF-inhibitor vemurafenib administration as monotherapy and in combination with cytosine arabinoside (ARA-C) and 2-chloro-2'-deoxyadenosine (2-CdA) in pediatric patients with different forms of LCH.Materials and methods. Fifteen patients with various forms of LCH were enrolled in the study. BRAF mutations were detected in 14 patients, mutation in the MAP2K1 gene was detected in one case. Patients with “risk organ” (RO) involvement were included in the first group (n = 9). These patients received combined therapy with vemurafenib and ARA-C/2-CdA. Patients without RO involvement, included in group 2 (n = 6), received vemurafenib as monotherapy. The assessment of the response to the therapy in group 1 was carried out in accordance with the DAS scale, in group 2 in accordance with the RECIST v1.1. The toxicity assessment in both groups was carried out in accordance with the CTCAE v5.0.Results. All patients in group 1 achieved non-active disease status with a median of 35 (28–61) days. In group 2 partial response to vemurafenib was achieved in 5 cases. Relapse after targeted therapy termination was diagnosed in two patients. Photodermatitis was the most common side effect of targeted therapy.Conclusions. The use of vemurafenib was effective in both groups. There were no cases of grade III–IV toxicity according to CTCAE v5.0 associated with vemurafenib administration in this study. The combination of vemurafenib and ARA-C/2-CdA showed high efficacy and good tolerability in group 1. Two cases of disease relapse after targeted therapy cessation in group 2 show that the monotherapy approach does not always allow to achieve long-term remission in LCH patients.
Familial DICER1 syndrome with thyroid pathology. A series of clinical cases
Authors: Ivanova N. V. , Zelenova E. E. , Polyakov V. G. , Lozovaya A. Yu. , Semenova V. V. , Kozlova V. M. , Korolev V. A. , Ushakova T.  L. , Panferova T. R. , Kozlov N. A. , Bidulya A. S. , Mikhailova S. N. , Rubanskaya M. V. , Varfolomeeva S.  R. 
Published: January 2024

Thyroid diseases in childhood occupy the second place after obesity in the structure of the general pathology of the endocrine system, eating disorders and metabolic disorders in children in the Russian Federation. Thyroid cancer in children makes up from 1.5 to 3 % of all malignant tumors, and from 8 to 22 % of malignant solid tumors of the head and neck, and the younger the child’s age, the more aggressive the disease proceeds.Familial forms of thyroid diseases may be associated with geographical features (living in iodine-deficient regions), but may also be part of hereditary syndromes, such as: multiple endocrine neoplasia syndromes (Sipple syndrome, Gorner syndrome, familial medullary thyroid cancer), DICER1 syndrome, Gardner syndrome, Cowden syndrome, McCune–Albright–Braitsev syndrome et al.This article describes several cases of thyroid pathology associated with DICER1 syndrome.