bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytomegalovirus promotes proliferation and survival of prostate cancer cells and constitutes a therapeutic target
Authors: Classon Johanna , Stenudd Moa , Zamboni Margherita , Alkass Kanar , Eriksson Carl-Johan , Pedersen Lars , Schörling Alrik , Thoss Anna , Bergh Anders , Wikström Pernilla , Adami Hans-Olov , Sørensen Henrik T , Druid Henrik , Frisén Jonas 
Published: October 2023

ABSTRACTMetastatic prostate cancer is incurable and new therapeutic targets and drugs are needed. Viruses are associated with several cancer types, but their connection to prostate cancer is unclear. Here we show that human herpes virus cytomegalovirus (CMV) infection is common in the healthy prostate epithelium as well as in prostate cancer, with 85% of tumors being infected to varying degrees. The CMV gene locusUL122-UL123upheld viral genome persistence in endogenously CMV infected prostate cancer cell lines. CMV promoted prostate cancer cell viability independently of androgen receptor status and anti-androgen resistance, partly through CMVUL97and the androgen signaling pathway. DNA intercalation mitigated CMV infection and reduced CMV-dependent tumor size in xenotransplantation experiments. The anti-herpes drug aciclovir showed modest effects, but the well tolerated CMV UL97 kinase inhibitor maribavir partly mimicked CMV loss by inducing apoptosis and attenuating proliferation, resulting in reduced tumor growthin vivo. We conclude that CMV infects prostate cellsin vivoand alters core prostate cancer cell properties, suggesting that it can be therapeutically targeted to improve prostate cancer outcomes.
Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks
Authors: Cheng Quen J. , Farrell Kylie , Fenn Jeffrey , Ma Zuchao , Makanani Sara K. , Siemsen Jonathan 
Published: October 2023

AbstractCells of the innate immune system retain memory of prior exposures through a process known as innate immune training. β-glucan, a Dectin-1 ligand purified from theCandida albicanscell wall, has been one of the most widely u:lized and well-characterized ligands for inducing innate immune memory. However, many Dectin-1 agonists exist, and it is not known whether all Dectin-1 ligands produce the same phenotype. Using a well-establishedin vitromodel of trained immunity, we compared two commercially available Dectin-1 agonists, zymosan and depleted zymosan, with the gold standard β-glucan in the literature. We found that depleted zymosan, a β-glucan purified fromSaccharomyces cerevisiaecell wall through alkali treatment, produced near identical training effects asC. albicansβ-glucan. However, untreated zymosan produced a distinct training effect from β-glucans at both the transcript and cytokine level. Training with zymosan diminished, rather than potentiated, induction of key cytokines such as TNF, IL-12, and IL-6. Zymosan activated NF𝓀B and AP-1 transcription factors more strongly than β-glucans. The addition of the toll-like receptor (TLR) ligand Pam3CSK4 was sufficient to convert the training effect of β-glucans to a phenotype resembling training with zymosan. We conclude that differential activation of TLR signaling pathways determines the phenotype of innate immune training induced by Dectin-1. These findings bring clarity to the specific question of which Dectin-1 agonists produce prototypical training effects and provide broader insight into how signaling networks regulate innate immune training.
The I Ching as a Potential Jungian Application: History and Practice
Authors: Zeng Jingchao 
Published: October 2023

AbstractSwiss psychiatrist Carl Jung had a lifelong interest in the I Ching after discovering it in 1919. Jung’s interest in the I Ching is arguably more practical than purely theoretical or intellectual, and references to I Ching divination appear frequently in his various publications, seminars, letters and clinical practice records. After a few observations on the history of the study of the I Ching in China, the author categorizes Jung’s three uses of the I Ching as physical use (to preview future potentials of outer reality), psychological use (to reveal one’s psychological state), and psychical approach (to engage with the divine through “神”[“shen”, spiritual agencies]). Finally, the author discusses the current Jungian engagement by demonstrating clinical cases in contemporary times. Some Jungian analysts practise I Ching divination to obtain insights into the physical and psychological state of therapeutic relationships and for personal development. This paper is a historical and critical engagement of the Jungian practice of I Ching divination.
Patents, foreign direct investment and economic growth in Australia, 1860–2010
Authors: Fleming Grant , Liu Zhangxin (Frank) , Merrett David , Ville Simon 
Published: October 2023

AbstractWe examine the long run relationship between innovation and economic development in Australia, using 150 years of data on patenting activity, and aggregate and sectoral economic indicators. Our initial results point to several important causal relationships, particularly the effects of patents on real GDP and of private capital formation on patents. We delve deeper at the sector level and find important causal relationships of patents with real foreign direct investment (FDI) since World War II. Australia's dependence on FDI for private capital formation served as an important stimulus for knowledge creation in key sectors including manufacturing, agriculture and mining.
A purebred South American breed showing high effective population size and independent breed ancestry: The Chilean Terrier
Authors: Mujica Paola C. , Martinez Víctor 
Published: October 2023

AbstractThe Chilean Terrier is a known breed in Chile that has not been genetically assessed despite its distinctive color patterns, agility, and hardiness across the diversity of climates encountered within the Chilean landscape. The population structure and its relatedness with other breeds, as well as the actual origin of the breed, remain unknown. We estimated several population parameters using samples from individuals representing the distribution of the Chilean Terrier across the country. By utilizing the Illumina HD canine genotyping array, we computed the effective population size (Ne), individual inbreeding, and relatedness to evaluate the genetic diversity of the breed. The results show that linkage disequilibrium was relatively low and decayed rapidly; in fact, Ne was very high when compared to other breeds, and similar to other American indigenous breeds (such as the Chihuahua with values of Ne near 500). These results are in line with the low estimates of genomic inbreeding and relatedness and the relatively large number of effective chromosome segments (Me = 2467) obtained using the properties of the genomic relationship matrix. Between population analysis (cross‐population extended haplotype homozygosity, di) with other breeds such as the Jack Russell Terrier, the Peruvian‐Inca Orchid, and the Chihuahua suggested that candidate regions harboring FGF5, PAX3, and ASIP, probably explained some morphological traits, such as the distinctive color pattern characteristic of the breed. When considering Admixture estimates and phylogenetic analysis, together with other breeds of American and European origin, the Chilean Terrier does not have a recent European ancestry. Overall, the results suggest that the breed has evolved independently in Chile from other terrier breeds, from an unknown European terrier ancestor.
Q&A
Authors: Maeda John , Heller Steven , Hoover Tim 
Published: October 2023

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures.Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.
Q&A
Authors: Schwartz Bob , Lopez Natalia Zuluaga 
Published: October 2023

As general manager for global design and user experience at GE Healthcare, and with experience at P&G and Motorola before that, Bob Schwartz has a few (!) thoughts about how to fertilize the relationship between design and business.As design manager for the UK's Portland Communications, a high‐end public relations firm, Natalia Zuluagalo Lopez has more or less built her job from scratch.
Connected by Design
Authors: Bethune Kevin 
Published: October 2023

The digital trends of our time promise more changes for all of us, and more opportunities for startup companies. Large corporates have watched the audacity of startups, and they recognize they need to start deliberately reimagining themselves to play some offense. BCG Digital Ventures partners with the world's most important corporations to invent, launch and scale game‐changing businesses. Our strategic designers work on each new venture as a critical part of each multidisciplinary team.Kevin Bethune spends a lot of time thinking about what digital connection will mean in the future. That's because his company, BCGDV, creates digital start‐ups for Fortune 500 companies.
Effect of Piascledine‐bacterial nanocellulose combination on experimental cutaneous wound healing in rat: Histopathological, biochemical and molecular studies
Authors: Panahi Nastaran , Hashemnia Mohammad , Rezaei Farid , Cheraghi Hadi 
Published: October 2023

AbstractThe study investigated the wound healing potential of Piascledine (an avocado/soybean mixture) alone and in combination with bacterial nanocellulose on rat cutaneous wounds. Full‐thickness excisional wounds (2 cm in diameter) were induced on the backs of 60 Sprague–Dawley rats, divided into four groups, treated with daily topical application of bacterial nanocellulose (BNC), Piascledine 10% (PSD 10%) and Piascledine+bacterial nanocellulose (PSD + BNC) (10 mg/disk) and normal saline (control) for 20 days. Wounds were monitored daily, and at 10, 20 and 30 days post‐injury (DPI), tissue samples were collected for biochemical, histopathological and molecular analyses. Treated rats with PSD and PSD + BNC showed a significant decrease in the wound area compared with other groups. PSD and particularly PSD + BNC modulated inflammation, improved fibroplasia and angiogenesis and scar tissue formation at short term. At the long term, they reduced the scar tissue size and improved collagen fibres alignment, tissue organization and remodelling as well as re‐epithelialization. PSD enhanced matrix metalloproteinase‐3 (MMP‐3) gene expression, collagen and glycosaminoglycans (GAGs) synthesis and decreased tissue inhibitor of metalloproteinase‐1 (TIMP‐1) gene expression at various stages of wound healing. The study concluded that topical application of Piascledine, particularly in combination with bacterial nanocellulose, promotes wound healing activity by modulating inflammation, regulating MMP‐3 expression and enhancing collagen and GAGs synthesis.
Peeling with retinoic acid in microemulsion for treatment of melasma: A double‐blind randomized controlled clinical study
Authors: de Andrade Ana Carolina Dias Viana , Coqueiro Raildo da Silva , Pithon Matheus Melo , Leite Mateus Freire 
Published: October 2023

AbstractObjectiveTo evaluate the clinical efficacy of peeling with a microemulsion formulation containing 1% retinoic acid.Materials and MethodsAfter development of the product, 60 patients with melasma were randomly divided into three groups (n = 20): Group 1–application of conventional 1% retinoic acid peeling (RA 1%). Group 2–application of 1% retinoic acid peeling in microemulsion (RA 1%M). Group 3–Application of placebo. The groups were submitted to four peeling sessions, fortnightly on Days 0, 15, 30, and 45, and analyzed at the time intervals of 0, 15, 30, 45, and 60 days. Evaluation was made by using the Melasma Area and Severity Index (MASI) and Melasma Quality of Life (MelasquoL) instrument. Hemato‐biochemical parameters were also evaluated at Days 0 and 60. After obtaining the results, normality was evaluated by means of the Kolmogorov–Smirnov test and afterwards, the following tests were applied: Friedman statistical (to test the effect of the treatments on the MASI index); Wilcoxon, (for comparison between pairs to test the effect of treatments on the MelasQoL index); Kruskal–Wallis, (to test the differences between the groups); and Mann–Whitney, (comparisons between treatments). The level of significance adopted was 5% (α = 0.05).ResultsThe three groups presented a significant reduction in the MASI index, indicating the effect of all the treatments on reducing the melasma (p < 0.001). A significant reduction in the stains was observed with the use of retinoic acid peeling delivered in microemulsion (62%) when compared with the conventional peeling with 1% retinoic acid in a conventional vehicle (26%) and the placebo (12%). There was also a significant reduction in the MelasQoL index (sum of all the aspects) in the three groups, indicating the effect of all the treatments, including the placebo, on the overall quality of life of those with melasma. However, RA 1%M the treatment that promoted the greatest effect on the quality of life of individuals. In percentage terms, the RA 1%M provided a mean reduction of 30% in the MelasQoL index, against 13% of the conventional treatment and only 4% of the placebo. When the hemato‐biochemical parameters were compared on Days 0 and 60, there were no significant changes in the results.ConclusionThe chemical peeling performed with RA 1%M was effective for the treatment of melasma, and was shown to be superior to the peeling performed with retinoic acid in a conventional vehicle, in reducing the stains and improving the quality of life of patients.
Association of metabolic syndrome and chronic kidney disease
Authors: Scurt Florian G. , Ganz Maximilian J. , Herzog Carolin , Bose Katrin , Mertens Peter R. , Chatzikyrkou Christos 
Published: October 2023

SummaryThe prevalence of kidney disease is increasing rapidly worldwide, reflecting rising rates of obesity, diabetes, and associated metabolic syndrome (MetS). Chronic kidney disease and related comorbidities such as obesity, diabetes, and hypertension place a significant financial burden on healthcare systems. Despite the widespread use of RAAS inhibitors, intensive blood pressure and glycemic control, and newer therapeutic options consisting of sodium/glucose cotransporter‐2 (SGLT‐2) inhibitors or glucagon‐like peptide‐1 (GLP‐1) receptor agonists, a significant risk of progression to end‐stage renal disease remains in the high‐risk obese and diabetic population. The MetS is a cluster of cardiovascular risk factors that adversely affect the development and progression of chronic kidney failure. According to the criteria of the World Health Organization, it is defined by visceral adiposity, impaired glucose tolerance or insulin resistance, atherogenic dyslipidemia, raised blood pressure, and microalbuminuria with a albumin‐to‐creatinine ratio ≥30 mg/g. At molecular level MetS is marked by a proinflammatory state and increased oxidative stress leading to various pathophysiological changes causing endothelial dysfunction and a hypercoagulable state. Because the kidney is a highly vascularized organ, it is especially susceptible for those microvascular changes. Therefore, the MetS and its individual components are associated with the premature development, acceleration, and progression of chronic kidney disease. Therefore, it is becoming increasingly important to elucidate the underlying mechanisms of MetS‐associated chronic kidney disease in order to develop new strategies for preventing and slowing the progression of renal disease. In this review, we will elucidate (i) the renal structural, hemodynamic, and metabolic changes that occur in obesity and obesity‐related kidney injury; (ii) the clinicopathological characteristics of obesity‐related kidney injury, primarily focusing on obesity‐associated glomerulopathy; (iii) the potential additional factors or predisposing factors that may turn patients more susceptible to renal structural or functional compensatory failure and subsequent injury.
Do reputational threats influence the rigidity of US agencies? A dynamic panel data approach
Authors: Boon Jan , Wynen Jan , Verhoest Koen 
Published: October 2023

AbstractWhat happens to organizational rigidity when public organizations faced reputational threats over time? Do they take external criticism as incentives to become less rigid and more innovative and flexible through employee involvement and empowerment? Or do reputational threats paradoxically contribute to the very rigidity that is often stereotyped as inherent parts of government? Building on threat‐rigidity theory, we test the temporal relation between reputational threats (both in terms of the direction of reputation and its turbulence) and organizational rigidity. We apply a dynamic panel data approach combining different data sources on 34 US agencies over a period of 13 years. The results show that organizational rigidity increased, both when reputations evolved negatively over time and when reputations evolved more turbulently. No combined effect of negative reputations and reputational turbulence was observed. Both sources of reputational threats independently precluded organizations from creating a climate of employee empowerment, involvement, flexibility, and innovation.
Keep My Teeth: An evaluation of multi‐disciplinary training in mouth care for people with intellectual developmental disorders
Authors: Nowghani Fargol , Lisiecka Dominika , Phelan Seán , Horan Paul , O'Reilly Louise , Howell Yvonne , Mac Giolla Phadraig Caoimhin 
Published: October 2023

AbstractAimTo evaluate a modular didactic training intervention called Keep My Teeth designed by special care dentists, for a range of healthcare students to provide oral homecare for people with intellectual developmental disorders (PwIDD).MethodsTo evaluate the intervention a one‐group pre‐test post‐test pre‐experimental research design was utilized. The intervention was delivered by virtual platforms or face‐to‐face, with a sub‐sample of participants also receiving practical training. Healthcare students included Speech and Language Therapy (SLT), Registered Nurse Intellectual Disability (RNID), Dental Science (DS), Dental Nursing (DN), and Dental Hygiene (DH).ResultsSixty‐three of the 147 trainees completed all surveys. A significant change in perspective on barriers was seen for most groups post‐training, with an increase in confidence in delivering oral care to PwIDD across disciplines; 67% of DH/DN students who took part in the practical training felt that the didactic training was just as effective without the practical training, while 42% of the DS students felt that was true.ConclusionsThe training interventions provided seem to have increased the awareness of study participants in relation to barriers to care, and increased their self‐efficacy towards, and intention to perform, oral homecare behaviors.
Science as a “Special”: Navigating the role of science specialist in urban elementary schools
Authors: Ronan Darcy M. 
Published: October 2023

AbstractThis ethnography explores the locally defined and culturally negotiated roles and responsibilities of elementary science specialists (ESS) in three New York City schools. Drawing upon interviews with ESS, classroom teachers, and building administrators, this study examines the roles and interactions of ESS with regards to instruction, support, and leadership as analyzed through a distributed leadership lens. The implementation pattern matched the characteristics of the science as a special model of elementary content specialization. While lacking specific qualifications or clearly defined roles, ESS were primary, exclusive, or supplementary providers of science instruction. Urban ESS leveraged relationships with various classroom generalists and faced challenges in navigating science leadership responsibilities such as curriculum coordination, communication, and support of classroom teachers.
Definability and decidability for rings of integers in totally imaginary fields
Authors: Springer Caleb 
Published: October 2023

AbstractWe show that the ring of integers of is existentially definable in the ring of integers of , where denotes the field of all totally real numbers. This implies that the ring of integers of is undecidable and first‐order nondefinable in . More generally, when is a totally imaginary quadratic extension of a totally real field , we use the unit groups of orders to produce existentially definable totally real subsets . Under certain conditions on , including the so‐called ‐number of being the minimal value , we deduce the undecidability of . This extends previous work that proved an analogous result in the opposite case . In particular, unlike prior work, we do not require that contains only finitely many roots of unity.
Propuesta de distribución de costos indirectos de fabricación por el método algebraico para complementar las metodologías de costeo tradicional y ABC en empresas manufactureras
Authors: Sierra Vargas José , Londoño Osorio José Iván 
Published: October 2023

En la actualidad, es cada vez mayor la exigencia de los mercados en cuanto al nivel de competitividad. Uno de los criterios de evaluación de esta son los costos de producción.
Se sabe que existen diversidad de sistemas de registro y clasificación de costos, y se es consciente de la problemática que se presenta a la hora de asignar los costos a los objetos de costo (productos, servicios, cliente, proyecto, pedido, etc.). Hasta el momento, muchas empresas utilizan el sistema tradicional de asignación, basado en establecer una tasa predeterminada para aplicarla a los objetos de costo, ya sea por horas de mano de obra, horas máquina o, simplemente, por el valor de las ventas de cada objeto de costo.
La necesidad actual de afinar esta distribución y asignación de costos indirectos sustenta el uso del método algebraico y se convierte en una solución complementaria cuando se presenta reciprocidad. Es decir que los centros de costos de servicios se prestan servicio entre ellos, así como a los departamentos productivos. La aplicación del método algebraico mejora la razonabilidad de los costos a obtener en cualquier metodología de costos.
Se propone el uso de los conceptos de álgebra lineal referentes al planteamiento y solución de ecuaciones y la aplicación práctica de las herramientas de Excel, las cuales facilitan su solución y complementan los métodos de costeo tradicional y ABC, previo a la distribución de los CIF por actividades.