bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketidakefektifan Bersihan Jalan Napas dengan Tindakan Fisioterapi Dada pada Anak yang Mengalami Bronkopneumoni Di RSU UKI Jakarta: Case Study
Authors: Albertina Tehupeiory Gloria , Sitorus Erita 
Published: February 2025

Bronchopneumonia is an infiltrate spreads to both lung hemispheres starting from the terminal bronchioles which further become blocked by exudate. This is often experienced by infants and children due to bacteria, viruses, fungi, and foreign things. The annual bronchopneumonia cases in Indonesian infants is estimated in the range of 10% -20%, with the Mortality Rate is 32 deaths per 1,000 live births before the age of 5 years old. The current case study report explains an overview of bronchopneumonia and the overcome of the nursing problem of ineffective airway clearance in three pediatric patients at RSU UKI Jakarta. In this case, the nursing process approach includes interviews, observations, implementation, and documentation of results. After that, the nursing actions were implemented for 3x24 hours, in this case is teaching deep breathing exercises, effective coughing, and chest physiotherapy for every 2 hours, fulfillment of oral warm fluids to help thin phlegm, as well as psychological comfort. In this case, the patient's parents can actually perform chest physiotherapy independently to increase coughing ability so that the sputum production decreases and respiratory function restores. Therefore, it will lead to the fulfillment of oxygen needed, thus the problem of ineffective airway clearance is overcome. Eventually, it is suggested that the family becomes a constant in the child's life as well as helping the child's healing. Therefore, the involvement of the family during the family-centered treatment process is important. In addition, as nursing care providers for patients and families, nurses need to improve their quality in paying attention to the biopsycho-socio-spiritual, cultural aspects, and have a caring character as a role model to carry out promotive, preventive, curative, and rehabilitative health care.

Keywords: Pediatric Nursing Care, Bronchopneumonia, Chest Physiotherapy, Ineffective Airway Clearance
Gambaran Kejadian Ikutan Pasca Imunisasi Covid-19 pada Mahasiswa Fakultas Kedokteran UKI Penyintas Covid-19 dan Non Penyintas Covid-19
Authors: Ria Simanjuntak Desy , Mamangkey Jendri , Winda Sari Lumban Tungkup Nive , Izdihar Mahaswari Anggi , Amalia Talitha , Roy Matthew Bethaniel 
Published: February 2025

Adverse Events Following Immunization (AEFI) is defined as 'any adverse medical event that occurs after immunization, but which does not necessarily have a cause-and-effect relationship with vaccine use. Research conducted by krammer, et al said that vaccine recipients with pre-existing immunity (seropositive) experienced systemic side effects with a much higher frequency than antibody-nave vaccines. UKI Medical Faculty student environment class 2018 and 2019. The research design used is descriptive research with a sample of primary data taken using google form as a media for filling out questionnaires with a sampling method with simple random sampling , then the data is collected and will be processed with the Microsoft program excel. The number of respondents in this study amounted to 229 respondents, consisting of 115 students of class 2018 and 114 students of class 2019. The percentage of students who were non-survivors of COVID-19 was 77.73% and survivors of COVID-19 was 27.73%. Types of vaccines 1,2, and 3 received by the two groups included Sinovac, Astrazeneca, Moderna, and Pfizer. Symptoms of AEFI in non-survivors of COVID-19 are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 88.3%, vaccine 2: 92.6%, vaccine 3: 93.8%), followed by other systemic symptoms such as myalgia., fever, and headache (vaccine 1: 11.7%, vaccine 2: 7.4%, vaccine 3: 6.2%). Symptoms of AEFI in COVID-19 survivors are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 69.05%, vaccine 2: 93.55%, in vaccines 3 respondents experienced mixed local and systemic symptoms. Adverse Event Following Immunization (AEFI) which dominated in both groups in the form of local symptoms such as pain at the injection site, followed by systemic symptoms such as fever, myalgia, and headache
Keywords: COVID-19, COVID-19 Vaccine, Adverse Events Following Immunization (AEFI)
Sosialisasi dan Edukasi Kandungan Nitrit dan Nitrat dalam Sayuran serta Dampaknya terhadap Kesehatan Di Desa Buntu Bedimbar
Authors: Sitorus Panal , Cintya Henni 
Published: February 2025

The conversion of nitrates into nitrites in food is not only in vegetables as the main source, but also in drinking water, as well as in other foods such as processed meat products. The amount of consumption allowed by FAO / World Health Organization for a body weight of 60 kilograms is 220 milligrams for nitrates and 8 milligrams for nitrites. This activity received a very good and enthusiastic response from mothers of family walfare movement community (FWMC) members and all village officials. This activity was accompanied by 30 participants consisting of 20 women and 10 people from village features. Next, an observational survey was attempted by distributing questionnaires to measure the level of description of nitrites and nitrates and their effects on health. Next, an observational survey was attempted by distributing questionnaires to measure the level of description of nitrites and nitrates and their effects on health. The results show that 90% of FWMC members mothers after participating in this activity recognize nitrites and nitrates and the negative effects they cause, so they can apply them in their respective households for the health and welfare of the family
Injective hydrogel encapsulating dental pulp stem cells for the treatment of traumatic optic nerve injury
Authors: Luo Lihua , Xing Zhenjie , Li Yao , Wang Ben , Dong Na , Sun Jiayi , Wang Shuimiao , Xu Yidi , He Yan , Li Lingli , Nan Kaihui , Ye Qingsong 
Published: February 2025

ObjectivesThe study aimed to evaluate the effect of GeLMA/bFGF hydrogel loaded with dental pulp stem cells (DPSCs) on the repair and regeneration of traumatic optic nerve injury.Materials and methodsGeLMA/bFGF hydrogel was photo-cross-linked by LED light. The physical–chemical properties and cytocompatibility of GeLMA/bFGF hydrogel after being squeezed (GeLMA/bFGF-SQ) were evaluated by SEM and degradation analyses, as well as live/dead and CCK-8 assays, respectively. The axon growth of PC12 cells was evaluated by MAP2 staining. The GeLMA/bFGF/DPSCs-SQ hydrogel was injected in situ into the lesion site to observe the repair of optic nerve injury. The number of retinal ganglion cells (RGCs) was calculated by βIII-tubulin staining. The length of regenerated axons was observed by CTB staining. Tissue recovery and axon growth of the optic nerve were observed by HE and TEM analyses, respectively.ResultsGeLMA/bFGF-SQ hydrogel had a porous structure and great degradability, as well as good cytocompatibility. Meanwhile, DPSCs-conditioned medium (DPSCs-CM) could promote the axon growth of PC12 cells. Moreover, the number of RGCs and the regeneration of axons of the optic nerve were the highest in the GeLMA/bFGF/DPSCs-SQ group. HE and TEM data revealed abundant newly and orderly arrangement of optic nerve axons that was observed in the damaged area of the GeLMA/bFGF/DPSCs-SQ group.ConclusionTransplantation of GeLMA/bFGF/DPSCs-SQ in situ provided an appropriate microenvironment for the repair and regeneration of injured optic nerves. Moreover, DPSCs combined with bFGF protected the RGCs from apoptosis and promoted optic nerve regeneration by secreting a series of neurotrophic factors.
Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study
Authors: Hou Yilin , Tian Peipei , Song Guangyao , Song An , Liu Dandan , Wang Zhimin , Shi Yihe , Tang Yale , Wang Xiaoyu , Li Luxuan , Ren Luping 
Published: February 2025

BackgroundCarotid atherosclerosis (CAS), a key precipitator of cardiovascular incidents, is linked to postprandial triglyceride-rich lipoproteins (TRL), as reflected by elevated triglycerides (TG) and remnant cholesterol (RC). This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. They received an OFTT after consuming a meal containing 60% fat (1500 kcal). Serum lipid profiles were monitored at fasting and 2, 4, 6, 8, and 10 h postprandially. The participants were categorized into postprandial normotriglyceridemia and postprandial hypertriglyceridemia groups based on their postprandial TG levels. After a 6-year follow-up, fasting lipid profiles and CAS status were reassessed. The baseline fasting and postprandial lipid levels in the CAS and non-CAS groups were compared. Repeated-measures analysis of variance was used to analyze the postprandial lipid profiles across different groups. Logistic regression models were constructed to assess the effects of postprandial TG and RC levels on CAS incidence.ResultsThe incidence of CAS in the postprandial hypertriglyceridemia group was 66.0%, which was significantly higher than the 13.3% observed in the postprandial normotriglyceridemia group (P &lt; 0.001). In the CAS group, postprandial TG and RC levels peaked 4 h after a high-fat meal and did not return to fasting levels, even after 10 h. The levels of 4h-postprandial TG (TG4h), maximum postprandial TG (TGmax), 4h-postprandial RC (RC4h), and maximum postprandial RC (RCmax) were significantly higher in the CAS group than in the non-CAS group (P &lt; 0.05). At baseline, TG4h (P &lt; 0.001), TGmax (P = 0.006), RC4h (P &lt; 0.001), and RCmax (P = 0.003) were statistically significant predictors of CAS, whereas fasting TG (P = 0.200) and fasting RC (P = 0.200) were not significantly associated with CAS.ConclusionThe standardized OFTT has predictive value for CAS, and elevated TRL levels after a high-fat meal in individuals with normal fasting lipid profiles may serve as an early marker for CAS.
Association of the Chinese visceral adiposity index with marrow adiposity in postmenopausal females
Authors: Zuo Xiaoyong , Miao Zeyang , Xu Run , Shi Dan , Chang Shixin , Li Guanwu , Luo Peng 
Published: February 2025

ObjectiveTo investigate the relationship between the Chinese visceral adiposity index (CVAI) and vertebral proton density fat fraction (PDFF).MethodsThe study included 181 postmenopausal females including 53 normal bone mineral density (BMD), 88 osteopenia, and 40 osteoporosis. Vertebral marrow PDFF was measured using Fat Analysis &amp; Calculation Technique imaging, and BMD was assessed via dual-energy X-ray absorptiometry. Bone turnover biomarkers and lipid metabolism were evaluated. The relationship between CVAI and PDFF was assessed using multivariable linear regression models, generalized additive models, and threshold effect analysis.ResultsThe mean BMD at the lumbar spine increased, and PDFF significantly decreased as quartiles of CVAI increased (P for trends &lt;0.05). Multivariable linear regression analysis revealed a clear negative correlation between CVAI and PDFF (regression coefficient β = −0.251, 95% CI, −0.303 to −0.200; P &lt; 0.001) after adjusting for age, time since menopause, waist circumference, body mass index, physical activity, and lipid profiles. The association with marrow PDFF remained significant (β = −0.202, 95% CI, −0.255 to −0.149, P &lt; 0.001) even after additional adjustment for BMD. Further analysis revealed an L-shaped non-linear relationship between CVAI and marrow PDFF after adjusting for age, time since menopause, waist circumference, body mass index, physical activity, lipid profiles, and BMD. An inflection point was identified at a CVAI of 128.3, below which each one-unit increase in CVAI corresponded to a more substantial decrease in marrow PDFF (β = −0.0055, 95% CI: −0.0064 to −0.0045; P &lt; 0.001). However, above this inflection point, each unit increase in CVAI was not significantly associated with a decrease in marrow PDFF.ConclusionsCVAI exhibited a nonlinear negative association with marrow adiposity within a suitable range, once CVAI crossed a definite threshold, PDFF ceased to increase. This finding suggests that a moderate visceral fat accumulation may enhance skeletal integrity, while excessive visceral fat could potentially have detrimental effects.
Zinc finger protein ZC3H18 is abnormally expressed in esophageal cancer tissues and facilitates the proliferation of esophageal cancer cells
Authors: Zhang Yujin , Wan Yilong , Li Jiaxi , Ju Sheng , Tong Xin , Wu Ji , Wu Hao , Zhang Liuqing , Shao Shengxiang , Wang Yuhong , Guo Lingchuan , Zhao Jun , Cao Lei , Jiang Dong 
Published: February 2025

IntroductionEsophageal cancer presents significant challenges due to the limited efficacy and severe side effects associated with conventional treatments. The identification of epigenetic regulatory molecules that are aberrantly expressed in tumors is crucial for elucidating the mechanisms underlying the development and progression of esophageal cancer.MethodsWe performed high-throughput methylation level analysis on cancerous and adjacent tissues from 25 patients, identifying the differentially methylated gene ZC3H18 utilizing Bismark software and data from TCGA. Esophageal cancer cell lines with ZC3H18 knockdown were used to validate the biological role of ZC3H18 in tumorigenesis in vitro and in vivo. Eukaryotic transcriptome sequencing analysis was conducted to investigate the potential mechanisms underlying ZC3H18 function.ResultsWe identified 30 genes exhibiting significant methylation differences between cancerous and adjacent non-cancerous tissues in 25 patients. Subsequent analysis utilizing the TCGA database revealed that the gene ZC3H18 is aberrantly expressed in tumor tissues and is closely associated with patient prognosis. Examination of esophageal cancer tissue samples demonstrated overexpression of the ZC3H18 protein, which was positively correlated with adverse prognosis indicators, including tumor differentiation, stage, and invasion depth. ZC3H18 knockdown significantly inhibited cellular proliferation, migration, invasion, and damage repair. Additionally, ZC3H18 significantly promoted tumor growth in vivo. The expression of various cytokeratins was significantly reduced following the ZC3H18 gene knockdown. ZC3H18 and multiple keratins were co-localized in esophageal cancer tissue.DiscussionZC3H18 gene exhibits differential methylation in esophageal cancer was positively correlated with unfavorable patient prognosis. ZC3H18 plays a critical role in the regulation of biological functions within esophageal tumors.
Effects of high stocking density on the growth performance, intestinal health and bile salts composition of broiler chickens
Authors: Dong Yuanyang , Zheng Yuqi , Liu Haoyu , Wang Yaru , Cui Jiaqing , Wu Yuan , Yan Lei , Miao Zhiqiang , Han Miaomiao , Huang Chenxuan , Li Peifeng , Su Yuan , Shen Yiru , Zhang Junzhen , Yuan Jianmin , Zhang Bingkun , Li Jianhui 
Published: February 2025

IntroductionThe intestinal dysfunction plays an important role in the decreased growth performance of broiler chickens under high stocking density. Gut microbiota plays an important role in maintaining intestinal health. However, the modulation pathway of gut microbiota by regulating the intestinal barrier and histomorphology remains unknown.MethodsOne hundred and forty-four male Arbor Acres broilers (22-d-old) with similar weight were randomly assigned to two treatments: a high (HSD, 20 broilers/m2) or low stocking density treatment (LSD, 14 broilers/m2), with six replicates per treatment. The experimental period was 20 days, from 22 to 42 days of age.ResultsThe final body weight at 42 days of age was lower in the HSD group (P = 0.0013) and average daily feed intake (P = 0.016) and weight gain of broilers from 22 to 42 days decreased (P = 0.012). In the HSD group on day 42, villus height and the ratio of villus height to the crypt depth in the ileum decreased (P &lt; 0.05); mRNA expression of tight junction proteins, occludin (P &lt; 0.01) and ZO1 (P &lt; 0.05), were downregulated; whereas IL-6, TNFα, and NFκB p65 (P &lt; 0.05) and IL-1β (P &lt; 0.01) were upregulated. The HSD treatment increased the relative abundance of Lactobacillus (P = 0.045) and decreased that of Alistipes (P = 0.031). Cecal concentrations of acetic (P &lt; 0.05) and butyric acids (P &lt; 0.05) decreased. Gut metabolites co-metabolized by the host and gut microbiota were altered in the HSD group, with decreases in glycerophospholipid and tryptophan metabolites negatively correlated with Lactobacillus (P &lt; 0.05). The metabolite content of conjugated bile acids decreased and free bile acids increased (P &lt; 0.05) with HSD. Bile salt hydrolase (BSH) was increased in the intestine of HSD-treated broilers (P &lt; 0.01). The total cholic acid content of the HSD group was lower in the jejunum and ileum (P &lt; 0.05) but higher in the cecum than in the LSD group (P &lt; 0.01).ConclusionHSD caused dysbiosis of the intestinal microbiota such as increased Lactobacillus, along with enhanced BSH activity and excessive unabsorbed free bile acids. This resulted in ileal epithelial cells damage, inflammation, decreased growth performance of broilers under high stocking densities.
Q-Der: a next-generation CoQ10 analogue supercharging neuroprotection by combating oxidative stress and enhancing mitochondrial function
Authors: Micucci Matteo , Gianfanti Federico , Donati Zeppa Sabrina , Annibalini Giosuè , Canonico Barbara , Fanelli Fabiana , Saltarelli Roberta , Osman Riham , Montanari Mariele , Lopez Daniele , Nasoni Gemma , Panza Giovanna , Bargagni Erik , Luchetti Francesca , Retini Michele , Mari Michele , Zappia Giovanni , Stocchi Vilberto , Bartolacci Alessia , Burattini Sabrina , Battistelli Michela 
Published: February 2025

BackgroundMitochondrial dysfunction and oxidative stress are central mechanisms in the progression of neurodegenerative diseases. This study first evaluated the toxicity of Q-Der (Q10-diacetate), a derivative of Coenzyme Q10, in HT22 hippocampal neurons under normal and oxidative stress conditions.MethodsHT22 cells were treated with Q-Der at 2.5, 5 and 10 µM with and without rotenone. Mitochondrial superoxide production (Mitosox), gene expression (via qRT-PCR), and protein levels (via Western blot) were measured. Morphological analyses were performed using transmission (TEM) and scanning (SEM) electron microscopes.ResultsQ-Der significantly reduced mitochondrial superoxide levels, particularly at 5 μM, and upregulated key mitochondrial biogenesis genes, including PGC-1α and TFAM. Additionally, it restored the expression of MT-ND1 and MT-COI, which were downregulated by rotenone. Western blot results showed a significant recovery in CV-ATP5A (complex V) expression (p &lt; 0.05), preserving mitochondrial ATP production. Morphological analyses further confirmed Q-Der’s ability to maintain cellular and mitochondrial structure under stress conditions.ConclusionThese findings suggest that Q-Der is non-toxic under normal conditions and protects against oxidative stress, supporting its potential as a therapeutic agent for neurodegenerative diseases.
Analysis of clinical efficacy of sacral magnetic stimulation for the treatment of detrusor underactivity
Authors: Pan Huixian , Tang Chenhao , Song Chen , Li Junhua 
Published: February 2025

ObjectiveThe objective of this study was to investigate the effectiveness and safety of sacral magnetic stimulation (SMS) in the management of detrusor underactivity (DU).MethodsWe retrospectively analyzed 66 patients with detrusor underactivity treated at Hangzhou Third People’s Hospital from January 2020 to October 2024, divided into two groups (33 cases each). Both groups had confirmed detrusor underactivity via urodynamic studies. The control group received conventional treatment (medication, catheterization, bladder training), while the observation group received SMS therapy. Urination diaries, urodynamic parameters and self-rating anxiety scale (SAS) were collected before and after the 4-week treatment to evaluate SMS efficacy and safety.ResultsAll patients in the observation group completed the course of sacral magnetic stimulation without experiencing any serious complications. After treatment, the observation group showed a significant reduction in the number of daily urinations, nocturnal urinations, SAS score and residual urine volume (RUV) (p &lt; 0.05) compared with the control group. There was no statistically significant difference in maximum cystometric capacity (MCC) (p &gt; 0.05). However, improvements were observed in SAS score, Detrusor Pressure at Maximum Flow (Pdet), Bladder Contractility Index (BCI), Maximum urinary Flow Rate (Qmax) and Average Urinary Flow Rate (Qavg) (p &lt; 0.05). The effective rate in the observation group was 78.78%, significantly higher than that in the control group (p &lt; 0.05). Although there was a slight decrease in the effective rate during the 6-month follow-up, the difference was not statistically significant (p &gt; 0.05).ConclusionIn conclusion, sacral magnetic stimulation therapy has demonstrated effectiveness in improving urinary function in patients with detrusor underactivity while maintaining a high level of safety.
Bibliometric analysis of cognitive dysfunction after traumatic brain injury
Authors: Hu Jihua , Zhu Ruiting , Zhang Xin , Zhang Yuchen , Liu Jixin , Wang Wenyang , Li Chiyin , Yang Tong , Zhang Ming , Niu Xuan 
Published: February 2025

BackgroundCognitive dysfunction after traumatic brain injury (TBI) significantly reduces quality of life and imposes a heavy burden on society. A detailed examination of research trends of cognitive dysfunction following TBI has not yet been conducted. This study aimed to examine the bibliometric analysis of cognitive dysfunction after traumatic brain injury over the past 20 years.MethodsLiterature on bibliometric analysis was retrieved from the Web of Science Core Collection (WoSCC) and Science Citation Index Expanded (SCI-E) from 2004 to 2023. The type of literature and the language were refined. A total of 1,902 articles were used for bibliometric analysis, including 1,543 (81.1%) original articles and 359 (18.9%) review articles. Data were retrieved on June 5, 2024.ResultsThe publication volume of articles was increasing year by year, with articles published in 537 journals. The Journal of Neurotrauma, with 130 articles, was the most productive and influential journal. The University of California System led in the number of articles published. There were 9,002 authors from 62 countries/regions. The USA and China were the top-ranked countries by article count. Pandharipande PP authored the highly cited article. Pick CG, as the author with the highest h-index. The top three of author keywords were traumatic brain injury, cognitive impairment, and mild traumatic brain injury. The topics of cognitive dysfunction after TBI were ferroptosis, cognitive decline, spinal cord injury, and prognosis.ConclusionOur findings provide valuable insights into cognitive dysfunction following TBI and highlight emerging trends for future research.