bluuebunny/crossref_metadata_2025_split huggingface dataset:
A thorough study and meta-analysis of the prognostic relevance of the C-reactive protein- albumin ratio in acute pancreatitis
Authors: Saad Hassan A. , Eraky Mohamed E. , El-Taher Ahmed K , Riad Mohamed , Farid Mohamed I , Sharaf Khaled 
Published: October 2023

Abstract
Background: Although most cases of acute pancreatitis (AP) are minor, severe cases are associated with a substantial risk of death. Acute pancreatitis (AP) is a common illness. Therefore, it is critical to assess AP severity as soon as possible. This review aimed to ascertain the predictive significance of the CRP to albumin ratio in individuals with AP.
Methods: We searched PubMed, Science Direct, and Cochrane Library electronic databases Until January 2023. Studies that reported the CRP/alb ratio at admission and its relationship to the severity or death of patients with AP were included. Using a random-effects model, we computed the pooled mean difference (MD) and 95% confidence interval (CI). The quality of the included studies was evaluated using the Newcastle-Ottawa scale.
Results: This meta-analysis combined data from six trials with a total of 2244 patients. Upon admission, the CRP/alb ratio was higher in patients with severe AP than in those with mild to moderate AP (pooled MD:3.59; 95% CI:2.51-4.68; p<0.00001). Additionally, non-survivor AP patients had a substantially higher CRP/alb ratio than survivor AP patients (pooled MD:2.12; 95% CI:0.43-3.8; p < 0.01).
In conclusion, individuals with AP may benefit from a high CRP/ALB ratio as a preliminary indicator of poor prognosis.
Seasonal Variation of Salmonella enterica prevalence in milk an cottage cheese along the dairy value chain in threee regions of Ethiopia
Authors: Nahusenay Henok , Bedassa Abdi , Tessema Tesfaye Sisay , Kovac Jasna , Vipham Jessie , Woldegiorgis Ashagrie zewdu 
Published: October 2023

Abstract

Seasonal fluctuations influence foodborne illness transmission and affect patterns of microbial contamination of food. Previous investigations on the seasonality of Salmonella enterica prevalence in dairy products in Ethiopia have been minimal. However, such data are needed to inform strategic development of effective interventions to improve food safety, as seasonal differences may affect intervention strategies. This study was conducted to identify differences in the prevalence of Salmonella between wet and dry season in milk and cheese samples. A longitudinal study design was utilized with a random sampling occurring during both dry and wet seasons. A total of 448 milk and cottage samples were collected from Oromia, South Peoples Nation and Nationality (SNNP), and Amhara regions. Samples were tested for Salmonella using the ISO 6579-1: 2008 method, followed by PCR confirmation. A chi-square test was conducted to assess the significance of differences in the prevalence of Salmonella between the two seasons. Results from this study showed a higher prevalence of Salmonella in all sample types during the dry season (P < 0.05). Moreover, when comparing raw milk, pasteurized milk, and cottage cheese samples, a significant difference was observed in Salmonella prevalence from raw milk samples (27.08%) collected in the Oromia region. Additionally, data showed a significantly higher prevalence of Salmonella in samples collected from raw milk producer (29.17%) during the wet season (P < 0.05). This study indicates that in order to enhance the safety of dairy products in Ethiopia, comprehensive, long-term awareness building on hygienic milk production and handling that consider seasonal influence is warranted.
HPAM-Biomass Phenol-Formaldehyde Resin Dispersion System: Evaluation of Stability
Authors: Zhao Dan , Yang Weili , Shen Guanglite , Feng HuiXia 
Published: October 2023

Abstract
PFR combined with polymers have a wide range of industrial applications as plugging agents for profile control and EOR. Due to the structural resemblance between lignin and phenol, there are possibilities for environmentally friendly phenol-formaldehyde resin manufacturing. SLPFR was synthesized by partially replacing phenol with lignin, which improved the utilization rate of lignin and achieved the purpose of environmental preservation and resource conservation. HPAM is the most widely used polymer in chemical methods for EOR. However, the stability of reservoirs with high salt and high temperature is weak under these conditions.To solve the problem of still low oil recovery in high-salt reservoir environments, polymer flooding is adopted, which utilises high molecular weight polymers to raise the viscosity of injected fluids, thereby improving sweep efficiency and altered mobility ratio between oil and injected fluid. We focus on the stability study of different molecular weight HPAM combined with SLPFR in metal ions and surfactants. The zeta potential and hydrodynamic diameter of HPAM-SLPFR system in Ca2+ were measured by dynamic light scattering and static light scattering, and the dispersion stability was analyzed. The interfacial energy modified DLVO theory was introduced to evaluate the stability of its colloidal solution, which made it possible to predict the aggregation behavior of SLPFR and the co-migration process of metal cations in real time.
Agricultural intensification in Lake Naivasha Catchment in Kenya and associated pollution
Authors: Onyango Joel , Kitaka Nzula , Bruggen J. J.A. , Irvine Kenneth , Simaika John 
Published: October 2023

Abstract

Investments in agricultural intensification in Sub-Saharan Africa aim to fulfill food and economic demands. However, the increased use of fertilizers and pesticides poses ecological risks to water bodies in agricultural catchments. This study focused on assessing the impact of agricultural intensification on nutrient and pesticide pollution in the L. Naivasha catchment in Kenya. The research revealed significant changes in the catchment's agricultural landscape between 1989 and 2019, driven by intensified agricultural expansion. As a result, nutrient and pesticide emissions have worsened the lake's trophic status, shifting it towards hypereutrophic conditions. The study found a weak relationship between total nitrogen (TN) and ∑DDT, indicating that an increase in TN slightly predicted a reduction in ∑DDT. Analysis also showed potential phosphorus (P) limitation at N3 site (Hippo Point) in the lake. Additionally, the observed DDD:DDE and (DDE + DDD):DDT ratios suggest recent use of banned DDT in the catchment. The study concludes that unsustainable agricultural expansion has transformed the L. Naivasha landscape, necessitating the adoption of practices that support water quality management to achieve the UN Sustainable Development Goals.
Spatial Pattern of Farmers-Herders Conflicts in Guma and Logo Local Government Areas, Benue State, Nigeria
Authors: Musa Halima Aliyu , Ekpa Dave Eleojo , Idris Musa Shehu , Laide Aderoju , Abubakar Abubakar Tanimu , Isah Zuweira , Salaudeen Fatima 
Published: October 2023

Abstract
This study was conducted on Spatial Pattern of Farmers-Herders Conflict in Guma and Logo LGAs, Benue State. Data used in this study include study area Shapefile, coordinates from Global Positioning System (GPS), number of conflict incidence and fatality from Armed Conflict Locations and Event Data (ACLED). Geospatial technique with the aid of ArcGIS software and descriptive statistics were employed to analyse the data. The finding reveals that from 2015-2018 the highest incidence and fatality rate occurred in 2018 and this could be attributed to incessant attack. The highest incidence occurred in Gbajimba and Ugba areas of Guma and Logo having 47 and 40 incidence correspondingly. Guma has the highest incidence and fatality rate within the study period. Policy on grazing should be enforced in the study area and more security personnel should be deployed to the area to avert further devastation.
Abnormal spontaneous neuronal activity and functional connectivity in Parkinson's disease with chronic pain: a resting-state fMRI study
Authors: Zou Nan , Zhang Jinru , Luo Yajun , Ya Yang , Ji Lirong , Bao yiqing , Jiang Zhen , Wang Aijun , Mao Chengjie , Wang Erlei , Fan Guohua 
Published: October 2023

Abstract

Background: The neural basis of pain in Parkinson’s disease (PD) is poorly understood. This study aimed to explore the alterations of spontaneous neuronal activity and functional connectivity (FC) pattern in PD with chronic pain by amplitude of low-frequency fluctuation (ALFF)and functional connectivity (FC).
Methods: A total of 41 PD patients with pain (PDP), 41 PD patients without pain (nPDP), and 29 matched pain-free normal healthy controls (NCs) were enrolled in the study. The non-motor symptoms questionnaire (NMSQ) and the visual analog scale (VAS) were applied to pain screening and pain severity assessment. ALFF and FC were measured by resting-state functional MRI (rs-fMRI). ALFF was applied to investigate regional cerebral activity, and FC was used to evaluate functional integration of the brain network.
Results: Compared with nPDP patients, PDP patients showed increased ALFF in the right superior frontal gyrus (SFG), supplementary motor area (SMA) and left paracentral lobule (PCL), precentral gyrus (PrG), while decreased ALFF in the right putamen. Only the ALFF value of the right putamen was negatively correlated with the VAS score in the PDP patients. PDP patients showed diminished FC in the right putamen with the midbrain, anterior cingulate cortex (ACC), orbito-frontal cortex (OFC), middle frontal gyrus (MFG), posterior cerebellar lobe, and middle temporal gyrus (MTG), as compared with nPDP patients.
Conclusion: This study does disclose that anomalous regional brain activity within the motor cortex and putamen, as well as aberrant functional integration of the putamen with multiple brain regions are involved in the neural mechanism of pain in PD patients.
Optimal Designs for Nonlinear Mixed-effects Models Using Competitive Swarm Optimizer with Mutated Agents
Authors: Cui Elvis Han , Zhang Zizhao , Wong Weng Kee 
Published: October 2023

Abstract

Nature-inspired meta-heuristic algorithms are increasingly used in many disciplines to tackle challenging optimization problems. Our focus is to apply a newly proposed nature-inspired meta-heuristics algorithm called CSO-MA to solve challenging design problems in biosciences and demonstrate its flexibility to find various types of optimal approximate or exact designs for nonlinear mixed models with one or several interacting factors and with or without random effects. We show that CSO-MA is efficient and can frequently outperform other algorithms either in terms of speed or accuracy. The algorithm, like other meta-heuristic algorithms, is free of technical assumptions and flexible in that it can incorporate cost structure or multiple user-specified constraints, such as, a fixed number of measurements per subject in a longitudinal study. When possible, we confirm some of the CSO-MA generated designs are optimal with theory by developing theory-based innovative plots. Our applications include searching optimal designs to estimate (i) parameters in mixed nonlinear models with correlated random effects, (ii) a function of parameters for a count model in a dose combination study, and (iii) parameters in a HIV dynamic model. In each case, we show the advantages of using a meta-heuristic approach to solve the optimization problem, and the added benefits of the generated designs.
Efficacy of different doses of corticosteroids on severe COVID-19 pneumonia
Authors: Zhang Ge , Su Lin , Wu Wenwen , Qiao Qing , Gao Shuncui , Zhang Yan , Zhang Yanmei 
Published: October 2023

Abstract
Objective: To investigate the efficacy of corticosteroids in the treatment of severe COVID-19 pneumonia at different doses.
Methods：Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated in the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received usual care plus high dose corticosteroids，below referred to as the high-dose group. The control group (27 patients) received usual care plus low-dose corticosteroids. Below referred to as the low-dose group. We collected baseline data, inflammatory markers after 3 days of treatment, body temperature recovery time, length of stay and 28-day all-cause mortality. The results of outpatient follow-up
were recorded after 1 month.
Result: There were no significant differences in 28-day mortality and length of stay. The number of days that body temperature returns to normal in high-dose group was shorter than low-dose group. The high-dose group was significantly better than low-dose group in reducing inflammatory factors (CRP IL-6). 20 discharged patients were given corticosteroid ranging from 8~16mg of methylprednisolone, depending on chest computed tomographic(CT) and clinical symptoms, after 1 month, in all discharged patients of use oral corticosteroid, the consensus was that the CT features had improved.
Conclusion: The high-dose corticosteroids have a positive significance for the reduction of inflammatory factors and the shortening of body temperature recovery time. In the treatment of severe COVID-19 pneumonia, we can try early high-dose, short-course corticosteroids.
Guinea Pig Herpes like Virus is a Gamma Herpesvirus
Authors: Stanfield Brent A. , Ruiz Emmanuelle , Choulgenko Vladimir N. , Kousoulas Konstantin G. 
Published: October 2023

Abstract
Guinea Pig Herpes-Like Virus (GPHLV) is a virus isolated from leukemic guinea pigs with herpes virus-like morphology described by Hsiung and Kaplow in 1969. GPHLV transformed embryonic cells from Syrian hamsters or rats, which were tumorigenic in adult animals. Herein, we present the genomic sequence of GPHLV strain LK40 as a reference for future molecular analysis. GPHLV has a broad host tropism and replicates efficiently in Guinea pig, Cat, and Green African-derived cell lines. GPHLV has a GC content of 35.45%. The genome is predicted to encode at least 75 open reading frames (ORFs) with 84% (63 ORFs) sharing homology to human Kaposi Sarcoma Associated Herpes Virus (KSHV). Importantly, GPHLV encodes homologues of the KSHV oncogenes, the latency associated nuclear antigen (LANA, ORF73) and viral cyclin (v-cyclin, ORF72) exhibiting 17.1% and 34.3% amino acid similarity, respectively. GPHLV is a Rhadinovirus of Cavia porcellus, and we propose the formal name of Caviid gamma herpesvirus 1 (CaGHV-1). GPHLV can be a novel small animal model of Rhadinovirus pathogenesis with broad host tropism.
Gaia photometric and kinematics studies of fouropen star clusters: King 13, Juchert-Saloranta 1,Teutsch 1, and Teutsch 5
Authors: T.Alsslegy Noorh , A.Harron Aly 
Published: October 2023

Abstract
This paper presents the results of the studying photometric, and kinematics offour open star clusters; namely King 13, Juchert-Saloranta 1, Teutsch 1, andTeutsch 5 utilizing the most recent data of Gaia EDR3. The most probable ofthe star members was computed using the ASteCA code and the numbers ofmembers of the clusters (N); (521) King 13, (429) Juchert-Saloranta 1, (414)Teutsch 1, and (191) Teutsch 5. The parameter structure of each object suchas cluster radii range from 3.00 to 7.00 arcmin. We obtained the distance fromSun 3.000±0.100 kpc, 4.891±0.554 kpc, 3.885±0.225 kpc, and 2.979±0.167 kpc,respectively. The values of age 0.818±0.043 Gyr, 0.9754±0.123 Gyr, 0.539±0.038Gyr, and 0.899±0.159 Gyr, respectively. The kinematical parameters have beencomputed; The position of the cluster convergent is computed by the AD diagrammethod, cluster velocity, center of the cluster, elements of solar motion, and spacevelocity components.
Cultivating Success: A Comprehensive Analysis of Integrated Weed Management Strategies and Their Impact on Groundnut (Arachis hypogaea L.) Yield and Sustainability
Authors: Hussain Abid , Fatima Shroz , Hammad Ahsan , BiBi Amna , Mustafa Mughees , Khan Ihsanullah , Khattak Sahir Hameed , Aslam Muhammad Aqeel , Khurshid Haris , khan Khalid , Jahanzaib Muhammad 
Published: October 2023

Abstract
Integrated weed management is a critical approach for controlling weeds in agricultural crops like groundnut (peanut) to minimize yield losses and maximize crop productivity. This approach combines various weed control strategies and methods to effectively manage weeds while minimizing the dependence on herbicides. The present study was also designed to evaluate the effects of integrated weed management in groundnut cultivation: (Arachis hypogaea L.) during summer season 2020-2021 at National Agricultural Research Centre Islamabd with combination of 10 weed management treatments in three replications. Pre-emergence application of S Metolachlor @ 2 L/ha and post emergence application of S Metolachlor @ 2 L /ha was applied on each of the replication. The weed control in terms of lowest weed density, lowest weed fresh weight, lowest weed dry matter, and best weed control efficiency depicted the efficiency of treatments to control weeds in the groundnut. The growth and yield attributes of groundnut viz, plant height, number of branches per plant, and pod yield/hectare were found higher as compared with other treatments. Although the treatment with organic mulch was also the best in terms of yield, the treatment with S Metolachlor at 2L/ha as a pre-emergence and Quizalofop-p at 2L/ha as a post-emergence had the highest maximum net monetary returns (394409 Rs/ha) and BC ratio (3.73). So, chemical control was recommended as most economically feasible weed management practice for groundnut in Pothwar Region of Pakistan.
Large rectangular cross-section tunnel undercrossing urban road by micro pipe jacking and joint assembly structure (MPJ &amp; JAS) method in soft soils
Authors: Zou Jia , Xie Xiongyao , Zhou Biao , Jiang Chunzhao , Zhang Zhen , Han Jianjun , Dai Qing , Shahrour Isam 
Published: October 2023

Abstract
With the continuous construction of urban traffic roads, more and more new roads are cut off by existing roads to form "dead end roads". There is an urgent need for a trenchless method suitable for urban ultra-shallow overburden to build the undercrossing tunnel. To solve this problem, this paper proposed the micro pipe jacking and joint assembly structure (MPJ & JAS) method, which has the characteristics of shallow burial depth, low cost, short construction time, flexible cross-section setting and high space utilization. The MPJ & JAS method construct a large cross-section tunnel through assembling small cross-section elements, quite different from traditional methods. Therefore, this paper designed a CT-shaped integrated joint, the mechanical performance of which was verified and clarified by tensile test. The bending test and finite element (FE) analysis proved the reliability of MPJ & JAS tunnel structure, and confirmed the structure performances such as the failure models, crack behaviors, load-deflection response and stress-strain distribution. Moreover, the influences of the steel plate thickness, concrete strength and shear connector spacing were determined by the FE analysis. On the basis of test results and reasonable assumptions, a theoretical design method considering the influence of the CT-shaped integrated joint was proposed, which can effectively predict the bending strength of the MPJ & JAS tunnel structure with an error of less than 10%. Finally, in view of the characteristics of the MPJ & JAS method, the suitable micro pipe jacking machine, soil reinforcement measure, hydraulic traction construction technology, high-precision guidance system and concrete construction quality detection method based on the phased array ultrasonic imaging technology were developed, supporting the accurate and efficient construction of the MPJ & JAS tunnel.
Influence of clinical expertise and practical experience on transfer accuracy in guided dental implant placement - An in vitro study
Authors: Reiff Florian Sebastian , Bischoff Charlotte , Woelfler Henriette , Roehling Stefan 
Published: October 2023

Abstract
Purpose
To investigate whether inexperienced users applying a static navigation system can perform in-vitro a fully guided implant placement protocol and achieve similar results in terms of accuracy compared to experienced clinicians.
Methods
Based on 36 identical resin models, a computer-assisted implant planning was performed and a surgical guide was produced accordingly. Three study groups were composed with 12 operators, each: control group with experienced surgeons (DOC), test group 1 with dental technicians (TEC) and test group 2 with non-specialists (OFC). Using a fully guided drilling protocol, two implants were placed into each of the 36 models. Subsequently, the differences between the virtually planned and final implant positions were determined and the transfer accuracy was evaluated.
Results
For the control group DOC, the mean value of axial deviation was 1.90±1.15 degrees, for 3-dimensional deviation at the implant base 0.52±0.33mm, for 3-dimensional deviation at the implant tip 0.76±0.39mm and for vertical deviation at the implant tip -0.11±0.51mm. For corresponding parameters, the mean values of test group TEC were 1.99±0.87 degrees, 0.42±0.21mm, 0.68±0.30mm and -0.03±0.33mm and for test group OFC 2.29±1.17 degrees, 0.63±0.35mm, 0.89±0.43mm and -0.24±0.57mm, respectively. The results did not reveal any statistically significant differences between the control and the 2 test groups (p˃0.05).
Conclusion
The results of the present in-vitro study demonstrated that inexperienced users applying a static navigation system can perform a fully guided implant placement protocol and achieve similar results in terms of accuracy compared to experienced clinicians in this specific in vitro setup.
Identification of the Shared Gene Signatures and Biological Mechanism in Chronic Atrophic Gastritis and Gastric cancer
Authors: Yang Liangjun , Zhang Xi , Fang Zheng , Zhu Jiajie , Liu Haiyan , Lou Feiyan 
Published: October 2023

Abstract
Chronic atrophic gastritis (CAG), a persistent inflammatory reaction in the gastric mucosa, is considered a precursor to gastric cancer (GC). However, the specific mechanism underlying the development of GC from CAG has not been fully elucidated. Therefore, it is essential to explore the genes and pathways driving CAG progression towards GC for the prevention, diagnosis, and treatment of CAG patients. In this study, we obtained 78 common genes shared between CAG and GC through database mining. KEGG and GO functional enrichment analyses identified 21 enriched pathways and 659 GO terms associated with these 78 genes. Utilizing the protein-protein interaction (PPI) network, we identified the top five hub targets: TP53, CTNNB1, EGFR, MUC1, and CD44. mRNA and protein expression levels of these targets were found to be higher in GC tissues compared to normal tissues. Furthermore, mRNA expression levels of TP53, EGFR, and CD44 correlated with poor overall survival (OS) in GC patients. These findings offer potential therapeutic targets for further clinical and basic research.