bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring aggression: Self‐reports, partner reports, and responses to provoking scenarios
Authors: O’Connor Daryl B. , Archer John , Wu Frederick W.C. 
Published: August 2002

AbstractThis paper describes three studies. The first is concerned with the relationship between the Aggression Questionnaire (AQ) and a peer‐report version of the AQ (AQ‐P). The results (from a sample of 77 men aged 19 to 55 years) showed agreement between the two versions, thus providing evidence for the congruent validity of the AQ‐P, and good internal consistency was shown for the subscales of the AQ and AQ‐P. The second study involved the development, piloting, and validation of a vignette‐based assessment of aggressive behavior, the Aggressive Provocation Questionnaire. The third concerned the use of the finalised Aggressive Provocation Questionnaire in a sample of 130 men (aged 17 to 54 years). The results show that prior self‐reported aggression (measured by the AQ) predicted responses to provoking scenarios. Younger men (< 28 years) showed an association between physical aggression and the aggressive action scale (of the Aggressive Provocation Questionnaire) in response to provoking scenarios. Older men (> 28 years) showed an association between physical aggression and the assertive action scale. The findings are discussed in relation to aggression measurement and changes in aggression with age. Aggr. Behav. 27:79–101, 2001. © 2001 Wiley‐Liss, Inc.
Acquired von Willebrand disease—hemostatic management of major orthopedic surgery with high‐dose immunoglobulin, desmopressin, and continuous factor concentrate infusion
Authors: Frank Rolf Dario , Kunz Dagmar , Wirtz Dieter Christian 
Published: August 2002

AbstractAcquired von Willebrand disease (aVWD) is a rare bleeding disorder that mimics congenital VWD in previously healthy individuals; it is most frequently associated with monoclonal gammopathy. Hemostatic therapy of aVWD is challenging due to the extremely shortened half‐life of endogenous and exogenous VWF. High‐dose intravenous immunoglobulin (ivIG) is recommended as the treatment of choice, usually rapidly normalizing coagulation; but in case of failure, alternative treatment options are not well explored. We report successful major orthopedic surgery in a 61‐year‐old woman with multiple myeloma IgG lambda and aVWD. IvIG alone failed to correct hemostasis. However, ivIG pretreatment improved the VWF ristocetin cofactor (VWF:RCo) half‐life from only 1.5 hr to more than 4 hr, allowing desmopressin infusions twice daily to maintain sufficient VWF:RCo levels. Because of diminishing desmopressin effect, we attempted for the first time in aVWD a continuous VWF/FVIII infusion (Haemate HS®, 2.1–2.7 FVIII U/kg/hr or 51–64 U/kg/day, respectively 4.6–6.0 VWF:RCo U/kg/hr or 110–145 U/kg/day) to reach constant factor levels. The steady‐state clearance was 2.4 mL/kg/hr for FVIII:C and 13.5 mL/kg/hr for VWF:RCo. During surgery, VWF:RCo, FVIII:C, and PFA‐100 closure time were normalized. Until day 5, VWF:RCo was kept above 50%, from day 6 to 10 at least 30% activity were attained. FVIII:C levels were always >70%. The clinical course was uneventful without bleeding. Two weeks after hip surgery the patient was discharged from the hospital without complaints. The therapy described can be recommended as safe and feasible for further evaluation in aVWD patients who are hyporesponsive to ivIG treatment alone. Continuous VWF/FVIII infusion can improve substitution therapy in aVWD. Am. J. Hematol. 70:64–71, 2002. © 2002 Wiley‐Liss, Inc.
CD34‐positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform
Authors: Foley R. , Soamboonsrup P. , Carter R.F. , Benger A. , Meyer R. , Walker I. , Wan Y. , Patterson W. , Orzel A. , Sunisloe L. , Leber B. , Neame P.B. 
Published: August 2002

AbstractAcute promyelocytic leukemia (APL) has a favorable prognosis. Current therapy includes chemotherapy used in combination with all‐trans‐retinoic acid (ATRA). Although the differentiating effects of ATRA on promyelocytes have been well established, in vitro studies have shown that less‐differentiated APL blasts (CD34+) demonstrate a variable responsiveness to ATRA. To assess the clinical relevance of this finding, we analyzed a cohort of 38 patients with t(15;17) and/or PML‐RARα APL to determine the incidence and laboratory features of CD34+ APL. Thirty‐two percent (12/38) of cases were CD34+. There was a difference in WBC at presentation between CD34+ and CD34− cases (34.6 ± 9.2, mean ± standard error vs. 5.4 ± 2.0, P = 0.009). Patients with CD34+ APL demonstrated a micro/hypogranular phenotype (75%) (P = 0.001), co‐expression of CD2+ (83%) (P = 0.001), and the bcr3 isoform (100%) (P = 0.017). In contrast, CD34− cases demonstrated hypergranular morphology (65%), CD2+ (15%), and the bcr1 isoform (50%). A high presenting WBC count (\G10 × 109/L) was associated with an inferior overall survival (Log rank = 0.0047). Patients with CD34+ APL demonstrated an incidence of early mortality of 50%. Despite a marked correlation between CD34 positivity and increased WBC count, overall survival of CD34+ and CD34− cases did not differ significantly in our small cohort. Immunophenotypic analysis for CD34 expression should be included in future large APL trials to determine if detection of CD34+ blasts represents an independent adverse prognostic factor. Am. J. Hematol. 67:34–41, 2001. © 2001 Wiley‐Liss, Inc.
Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
Authors: Tabrizi Arash Rafii , McGrath Sean D. , Blinder Morey A. , Buchman Timothy G. , Zehnbauer Barbara A. , Freeman Bradley D. 
Published: August 2002

AbstractWarfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication. Am. J. Hematol. 67:144–146, 2001. © 2001 Wiley‐Liss, Inc.
Non‐anemic homozygous βo thalassemia in an African‐American family: Association of high fetal hemoglobin levels with β thalassemia alleles
Authors: Divoky Vladimir , Mrug Michal , Thornley‐Brown Denyse , Divoka Martina , Prchal Josef T. 
Published: August 2002

AbstractWe have studied a four‐generation (23 subjects) African‐American family with βo thalassemia and high fetal hemoglobin (HbF) levels. The βo thalassemia in this family is due to the splicing site mutation, β IVS2+1G→A, that leads to aberrant mRNA processing and the absence of β globin. Two members of this family are homozygous for βo thalassemia and are non‐anemic. All family members who are heterozygous for the β IVS2+1G→A mutation have elevated HbF, with the exception of two individuals who also have severe α‐globin chain deficiency. We excluded linkage with the hereditary persistence of fetal hemoglobin loci on chromosomes 6 and X. We also excluded the presence of all previously described determinants in the β globin gene cluster associated with elevated HbF production. One thalassemia allele is in the Cameroon‐like (HS2)/Benin‐like β globin gene cluster haplotype, and the other is in the Senegal‐like (HS2)/Benin‐like β globin gene cluster haplotype. We speculate that in the homozygotes, those erythroid cells that express low to absent levels of γ globin are selectively destroyed. In contrast, in the heterozygotes, the presence of the normal β globin allele would ameliorate the globin chain imbalance and thus allow survival of erythroid cells that express the abnormal transcript, leading to a typical βo thalassemia phenotype. Thus, the heterocellular γ globin expression together with in vivo preferential survival of HbF‐containing erythroid cells ameliorates Cooley's anemia in the βo thalassemia homozygotes. It remains to be determined what sequences linked to each thalassemia allele and what trans‐acting factors contribute to high HbF levels. Am. J. Hematol. 68:43–50, 2001. © 2001 Wiley‐Liss, Inc.
Re: Response to: Mortality among rubber chemical manufacturing workers by M.M. Prince et al. Am. J. Ind. Med. 2000. 37:590–598. I. Reply to Valentgas et al.'s letter to the editor
Authors: Prince Mary M. , Ward Elizabeth M. , Ruder Avima M. , Salvan Alberto , Roberts Dennis R. 
Published: August 2002

AbstractWe appreciate the opportunity to respond to comments by Valentgas and colleagues regarding our report examining mortality among rubber chemical manufacturing workers [Prince et al., 2001]. Following are our responses to their comments, focusing on the authors' main points:
Is it safe on deck? Fatal and non‐fatal workplace injuries among Alaskan commercial fishermen*
Authors: Thomas Timothy K. , Lincoln Jennifer M. , Husberg Bradley J. , Conway George A. 
Published: August 2002

AbstractBackgroundCommercial fishing in Alaska accounts for an occupational fatality rate that is 28 times the rate for all U.S. workers. Most deaths are attributed to vessel sinking or capsizing. However, many deaths and most non‐fatal injuries are not related to vessel loss. This paper describes injuries that occur on the dock or on the fishing vessel.MethodsData from fishing fatalities and non‐fatal injuries between 1991–1998 were analyzed using the Alaska Occupational Injury Surveillance System and the Alaska Trauma Registry.ResultsThere were 60 workplace deaths unrelated to vessel loss; most from falls overboard, others from trauma caused by equipment on deck. There were 574 hospitalized injuries, often from falls on deck, entanglement in machinery, or being struck by an object.SummaryFishing boats are hazardous working environments. Further efforts are required to prevent falls overboard and on deck, and to redesign or install safety features on fishing machinery and equipment. Am. J. Ind. Med. 40:693–702, 2001. Published 2001 Wiley‐Liss, Inc
Mica dust as a cause of severe pneumoconiosis
Authors: Zinman Carron , Richards Guy Anthony , Murray Jill , Phillips James Ian , Rees David John , Glyn‐Thomas Raymond 
Published: August 2002

AbstractBackgroundMica exposure is frequent in mines, mills, agriculture, construction, and industry. This is a case report of possible mica pneumoconiosis.MethodsCase report and description of pathology. Histology slides were subjected to spectroscopic examination.ResultsFibrosis in the presence of mica, without evidence of silica was confirmed.ConclusionsThis report indicates that mica exposure may result in mica pneumoconiosis. Am. J. Ind. Med. 41:139–144, 2002. © 2002 Wiley‐Liss, Inc.
Prevalence of cigarette smoking by occupation and industry in the United States*
Authors: Bang Ki Moon , Kim Jay H. 
Published: August 2002

AbstractBackgroundThis study was undertaken to estimate the most recent prevalence of cigarette smoking by occupation and industry in the US, using the data from the third National Health and Nutrition Examination Survey (NHANES III), 1988–1994.MethodsIncluded in NHANES III are data on the cigarette smoking status, occupation, industry, and other demographic information of US non‐institutionalized civilians obtained through household interview surveys. The study population included 20,032 adults aged 17 years and older. To estimate the prevalence of cigarette smoking across occupation and industry groups, we used the Survey Data Analysis (SUDAAN) software.ResultsThe prevalence of cigarette smoking was highest among material moving occupations, construction laborers, and vehicle mechanics and repairers. The lowest smoking prevalence was found among teachers. Among industry groups, the construction industry had the highest prevalence of cigarette smoking.ConclusionsThese findings provide information useful for targeting education activities focusing on adverse health effects of cigarette smoking and also for indirect adjustments in analysis of morbidity and mortality by occupation. Am. J. Ind. Med. 40:233–239, 2001. Published 2001 Wiley‐Liss, Inc.
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome
Authors: Richtsmeier Joan T. , Zumwalt Ann , Carlson Elaine J. , Epstein Charles J. , Reeves Roger H. 
Published: August 2002

AbstractTrisomy for chromosome 21 (Chr 21) has profound effects on development that result in a constellation of phenotypes known as Down syndrome (DS). Distinctive craniofacial manifestations are among the few features common to all individuals with DS. The characteristic face of a person with DS results primarily from maldevelopment of the underlying craniofacial skeleton. The Ts65Dn mouse, which has segmental trisomy 16, producing dosage imbalance for about half the genes found on human Chr 21, exhibits specific skeletal malformations corresponding directly to the craniofacial dysmorphogenesis in DS. Here we demonstrate that Ts1Cje mice, which are at dosage imbalance for about 3/4 of the genes triplicated in Ts65Dn, demonstrate a very similar pattern of anomalies in the craniofacial skeleton. However, one characteristic of Ts65Dn mice, a broadening of the cranial vault contributing to brachycephaly, is not seen in Ts1Cje mice. These observations independently confirm that a dosage imbalance for mouse genes orthologous to those on human Chr 21 has corresponding effects in both species. The subtle differences in the craniofacial phenotypes of Ts1Cje and Ts65Dn mice have implications for elucidation of the mechanisms by which this aneuploidy disrupts development. © 2001 Wiley‐Liss, Inc.
Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay
Authors: Bribiescas Richard G. 
Published: August 2002

AbstractLeptin is a recently discovered peptide hormone secreted primarily from adipocytes in humans and other mammals; it is a reflection of fat stores, and has been associated with reproductive function. However, few leptin measurements are available from nonindustrialized populations, including contemporary hunter/gatherer communities undergoing the transition to sedentary agriculture. This investigation reports single‐sample serum leptin measurements in healthy Ache Amerindian males (n = 21; average age, 32.8 ± 3.4 SE) and females (n = 12; average age, 31.3 ± 4.3) in eastern Paraguay. Ache leptin concentrations were much lower than in industrialized populations, although significant sexual dimorphism was evident (female 5.64 ng/ml ± 0.91 SE vs. male 1.13 ng/ml ± 0.08; P < 0.0001). Indeed, female leptin levels were similar to those of anorexic women, despite apparently adequate adiposity. Controlling for fat percentage, no significant sex difference was evident, suggesting that adiposity was the primary source of leptin variation. Body fat percentage was highly correlated with leptin in females (r2 = 0.72; P < 0.0005) but not males, who exhibited a modest negative correlation (r2 = 0.25; P < 0.03). Weight (r2 = 0.45; P = 0.02) and BMI (kg/m2) (r2 = 0.81; P < 0.0001) were also significantly correlated in females but not males. These results suggest that: 1) clinical leptin norms based on industrialized populations may represent the highest range of human variation and may not be representative of most human populations; 2) hormonal priming may underlie population variation in leptin profiles; and 3) the relative importance of leptin as a proximate mechanism regulating reproductive effort during human evolution may have been modest. Am J Phys Anthropol 115:297–303, 2001. © 2001 Wiley‐Liss, Inc.
Simple method for developing percentile growth curves for height and weight
Authors: Ward Richard , Schlenker Janet , Anderson Gregory S. 
Published: August 2002

AbstractThe present paper demonstrates the ease of use of method I by Preece and Baine ([1978] Ann Hum Biol 5:1–24) in generating smoothed growth curves for both height and weight. Using the National Center for Health Statistics (NCHS) growth curve data, smoothed curves were developed and compared to those produced using the least‐squares‐cubic‐spline method. Based on the lower sum of squares and better fit of shape as indicated by residual examination, it was concluded that the method I curve fitting procedure by Preece and Baine ([1978] Ann Hum Biol 5:1–24) fit centile growth curves for height and weight in 2–18‐year‐old male and female children as well as, if not better than, the least‐squares‐cubic‐spline method used in developing the 1979 NCHS growth curves. Further, as this paper demonstrates, smoothed curves can be generated on a desktop computer using readily available software (the SOLVER function within Microsoft EXCEL). Am J Phys Anthropol 116:246–250, 2001. © 2001 Wiley‐Liss, Inc.
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
Authors: Mitchell Thomas W. , Mufson Elliott J. , Schneider Julie A. , Cochran Elizabeth J. , Nissanov Jonathan , Han Li‐Ying , Bienias Julia L. , Lee Virginia M.‐Y. , Trojanowski John Q. , Bennett David A. , Arnold Steven E. 
Published: August 2002

AbstractAbnormally phosphorylated tau accumulates as neurofibrillary tangles and neuropil threads in older persons with and without Alzheimer's disease. The relationship between neurofibrillary tangles and neuropil threads and how they relate to cognitive function is unknown. This study investigated the relationship between phosphorylated tau lesions and cognitive function in 31 persons participating in the Religious Orders Study, a prospective, longitudinal clinicopathological study of aging and Alzheimer's disease. All subjects underwent detailed neuropsychological performance testing within a year of death and evidenced a spectrum of cognitive performance ranging from normal abilities to mild dementia. Measures of neurofibrillary tangle density and phosphorylated tau immunoreactive structures (predominantly neuropil threads) in the entorhinal and perirhinal cortices by quantitative image analysis were significantly correlated (r = 0.5). In multiple linear regression analyses controlling for age, sex, and education, parahippocampal neurofibrillary tangles and neuropil threads were significantly lower in persons without cognitive impairment compared to those with mild cognitive impairment and/or Alzheimer's disease. Further, neurofibrillary tangles were significantly correlated to measures of episodic memory but not other cognitive abilities; neuropil tangles were not significantly related to memory or other cognitive functions. These data indicate that phosphorylated tau pathology in the ventromedial temporal lobe develop prior to the onset of clinical dementia and their presence is associated with cognitive impairment, particularly impairment of episodic memory.
Novel locus for autosomal dominant pure hereditary spastic paraplegia (SPG19) maps to chromosome 9q33–q34
Authors: Valente Enza Maria , Brancati Francesco , Caputo Viviana , Bertini Enrico , Patrono Clarice , Costanti Danilo , Dallapiccola Bruno 
Published: August 2002

AbstractHereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. We report on an Italian family affected by ADPHSP for which we excluded linkage with the known loci and performed a genome‐wide search. Linkage analysis and haplotype construction permitted the identification of a novel ADPHSP locus on the long arm of chromosome 9, designated SPG19. The phenotype was characterized by late onset (range, 36–55 years) and mild disability, with only 1 patient bound to a wheelchair after 31 years of disease. Urinary disturbances (urgency and/or incontinence) were always present, even in young patients with a short disease history.
High‐density polyethylene/carbon black conductive composites. I. Effect of CB surface modification on its resistivity–temperature behavior
Authors: Zhang Jian‐Feng , Zheng Qiang , Yang Yi‐Quan , Yi Xiao‐Su 
Published: August 2002

AbstractThe effect of the interaction between a polymeric matrix and conductive particles of carbon black (CB), especially the interaction enhanced by oxidizing CB (o‐CB), on the resistivity–temperature behavior of its composites was studied. The results reveal that the interaction between ethylene‐vinyl‐acetate and CB is stronger than that between high‐density polyethylene and CB. The room temperature resistivity of the o‐CB filled system subsequent to thermal cycles increases to a lower extent in comparison with those filled with virgin CB. Moreover, the resistivity decrease of composites filled with o‐CB needs a longer time than that of the virgin CB filled system during isothermal annealing, meaning that the resistivity–temperature behavior of the former is much more stable than that of the latter. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 3112–3116, 2002; DOI 10.1002/app.10049
Thermal analysis of solution copolymers of styrene with N‐phenylmaleimide
Authors: Liu Guodong , Li Xiucuo , Zhang Liucheng , Qu Xiongwei , Liu Pange , Yang Liting , Gao Jungang 
Published: August 2002

AbstractFree‐radical–initiated copolymerization of N‐phenylmaleimide (NPMI) with styrene (St) at 110°C in a toluene solution initiated by AIBN was carried out by a semibatch method. The compositions of the copolymers were determined by using an elemental analyzer. The glass‐transition temperatures of the copolymers were measured by differential scanning calorimetry. All the semibatch copolymers show a single glass‐transition temperature that increases markedly with increasing NPMI content in the copolymers. The thermal stabilities of the copolymers were studied by using a programmed thermogravimetric analysis technique. Copolymers show a considerable increase in thermal stability and different degradation reaction mechanisms with increasing content of NPMI. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 417–422, 2002
Crosslinked PVC polymerization: Study on process dependencies
Authors: Han Sang Phil , Park Kyung Jun , Lee Kyungwoo 
Published: August 2002

AbstractA systematic study of how different processes and crosslinking agents affect the crosslinked polymerization of poly(vinyl chloride) (PVC) to be used for plastisol application was carried out. Two processes, microsuspension (MS) and seeded polymerization (SP), and two crosslinking agents, diallyl phthalate (DAP) and 1,3‐butanediol dimethacrylate (BDMA), were considered. Variations in degree of polymerization and gel content as functions of conversion, as well as the amount of crosslinking agent, was experimentally investigated for both processes and the results were precisely analyzed. We found that the microsuspension process is much better for crosslinked polymerization of PVC to be used for plastisol application; the seeded polymerization process was restricted by the transfer of crosslinking agents to the polymerization sites. Diallyl phthalate was proven to be a good crosslinking agent as generally known until now. Consequently, to perform crosslinked PVC polymerization in industry, the type of process should be taken into account and proper materials and steps should be set up. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 1947–1954, 2002