bluuebunny/crossref_metadata_2025_split huggingface dataset:
EKSISTENSI KEDUDUKAN SERTA PERAN MAHKAMAH KONSTITUSI DALAM PEMAKZULAN (IMPEACHMENT) PRESIDEN DAN/ATAU WAKIL PRESIDEN PASCA AMANDEMEN UUD NRI 1945
Authors: Islami Nisa Nur , Riwanto Agus 
Published: November 2023

Kedudukan Presiden sebagai lembaga eksekutif dalam sistem pemerintahan presidensial memiliki tanggung jawab penuh sebagai kepala negara serta sebagai kepala pemerintahan. Hal ini tidak menutup kemungkinan bahwa Presiden maupun Wakil Presiden dapat melakukan pelanggaran hukum sehingga bisa diberhentikan pada masa jabatannya. Indonesia merupakan negara hukum. Konsekuensi sebagai negara hukum ialah harus ditegakkannya mekanisme checks and balances. Hal tersebut dapat ditunjukkan dengan adanya Mahkamah Konstitusi dalam proses pemakzulan (impeachment). Penelitian ini bertujuan untuk mengkaji eksistensi kedudukan serta peran Mahkamah Konstitusi dalam konteks pemakzulan (impeachment) Presiden dan/atau Wakil Presiden pasca amandemen UUD NRI 1945 baik secara filosofis, sosiologis, maupun yuridis. Penelitian ini merupakan penelitian hukum normative yang bersifat preskriptif dengan pendekatan konseptual. Kesimpulan dari penelitian ini menunjukkan bahwa eksistensi Mahkamah Konstitusi dalam proses pemakzulan (impeachment) di dalam UUD NRI 1945 pasca amandemen terdapat pada Pasal 7B ayat (4) dan Pasal 24C ayat (2).
ANALISIS DAMPAK RENCANA PEMEKARAN KELURAHAN JEBRES KOTA SURAKARTA TERHADAP PELAYANAN PUBLIK DAN APARATUR PEMERINTAHAN
Authors: Utami Ayu Tri , Achmad . 
Published: November 2023

Pembentukan, pengahapusan, dan penggabungan kelurahan terkait dengan rencana pemekaran Kelurahan Jebres Kota Surakarta yang sedang berjalan. Selanjutnya mengkaji tentang dampak positif dan negatif yang akan terjadi atas rencana pemekaran Kelurahan Jebres Kota Surakarta pada aspek pelayanan publik dan aparatur pemerintahan.Penelitian hukum ini menggunakan penelitian normatif yang bersifat preskriptif, Sumber bahan hukum terdiri dari bahan hukum primer dan bahan hukum sekunder, Teknik pengumpulan bahan hukum yang digunakan pada penelitian ini adalah studi kepustakaan dengan cara mempelajari literatur dari buku, jurnal, artikel, dan bahan kepustakaan lainnya yang berkitan dengan masalah yang diteliti serta peraturan yang berhubungan dengan penelitian ini. Berdasarkan penelitian dan pembahasan, maka dapat disimpulkan bahwa rencana pemekaran Kelurahan Jebres Kota Surakarta ditinjau dengan pengaturan pembentukan kelurahan baru yang terdapat dalam Permendagri Nomor 31 Tahun 2006 tentang pembentukan, penghapusan, dan penggabungan kelurahan, belum memenuhi salah satu persyaratan pemekaran kelurahan yaitu syarat minimal luas wilayah dari kelurahan yang dimekarkan yaitu minimal 3 km2 dimana Kelurahan Jebres memiliki wilayah seluas 3,17 km2 yang akan dimekarkan menjadi 2 (dua) wilayah kelurahan yakni Kelurahan Jebres dan Kelurahan Kentingan dimana ketika pemekaran terjadi luas wilayah masing-masing kelurahan tersebut adalah kurang dari 3 km2. Dampak positif dari rencana pemekaran Kelurahan Jebres Kota Surakarta terhadap pelayanan publik dan aparatur pemerintahan antara lain;. Pertama, pelayanan publik menjadi lebih berkualitas dan memuaskan masyarakat; Kedua, meningkatnya efektifitas pelayanan kepada masyarakat; Ketiga, meningkatkan pengelolaan potensi daerah; Keempat, Penambahan sumber daya manusia aparatur pemerintah kelurahan yang berkualitas. Dampak negatif dari rencana pemekaran Kelurahan Jebres antara lain; Pertama, besarnya anggaran biaya pengadaan personel aparatur pemerintah dan sarana prasarana baru; Kedua, perubahan data administrasi kependudukan dan administrasi lainnya yang rumit; Ketiga, aparatur pemerintah yang baru cenderung belum terlalu menguasai dapat kewalahan untuk melayani masyarakat.
PELAKSANAAN PERAN PARTISIPASI DALAM PENGELOLAAN ALOKASI DANA DESA DI DESA NGAGLIK KECAMATAN SAMBI KABUPATEN BOYOLALI
Authors: Farhan Iqbal , Achmad . 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui bagaimana pelaksanaan dan hambatan peran partisipasi masyarakat dalam pengelolaan Alokasi Dana Desa di Desa Ngaglik Kecamatan Sambi Kabupaten Boyolali. Penelitian ini merupakan penelitian hukum empiris yang bersifat deskriptif dengan pendekatan kualitatif. Jenis dan sumber data penelitian yang digunakan dalam penelitian ini adalah data primer dan data sekunder dengan teknik pengumpulan data melalui wawancara dan pengambilan informasi studi tekstual untuk mengkaji data sekunder. Kemudian dianalisis menggunakan teknik analisis data dengan model analisis kualitatif. Hasil penelitian menunjukkan Peran partisipasi masyarakat dalam pengelolaan Alokasi Dana Desa berjalan dengan baik dan maksimal, dilihat dari (1) Voice (suara/aspirasi) masyarakat dalam pengelolaan ADD, (2) Acces (akses) masyarakat dalam pengelolaan ADD, dan (3) Control (kontrol/pengawasan) masyarakat dalam pengelolaan ADD, dimana mulai dari tahapan perencanaan dibuat secara musyawarah antara pemerintah desa dengan masyarakat mengenai besaran penetapan anggaran hingga pelaksanaan hingga pelaporan sehinggan masyarakat dengan baik dan maksimal berperan dalam setiap tahapan ADD. Lalu, Hambatan Peran Partisipasi masyarakat dalam Pengelolaan ADD di Desa Ngaglik Kecamatan Sambi Kabupaten Boyolali meliputi berbagai hal. Pertama, Hambatan Internal (1) Tingkat Pendidikan Sumber Daya Manusia (SDM) (2) Minimnya rasa saling percaya diantara para pelaku. (3) Perbedaan kepentingan yang tidak dapat dikompromikan setiap pelaku. Kedua, Hambatan Eksternal (1) Faktor Pekerjaan (2) Masalah Ekonomi Masyarakat.
Mild Internet Use Induces Epigenetic Alterations of Key Neurotransmission Genes in Salivary DNA of Young University Students
Authors: Annunzi Eugenia , Cannito Loreta , Bellia Fabio , Mercante Francesca , Vismara Matteo , Benatti Beatrice , Domenico Alberto Di , Palumbo Riccardo , Adriani Walter , Dell'Osso Bernardo , D'Addario Claudio 
Published: November 2023

Abstract
The potentially problematic use of the Internet is a growing concern worldwide, which causes and consequences are not completely understood yet. The neurobiology of Internet addiction (IA) has attracted much attention in scientific research, which is now focusing on identifying measurable biological markers. Aim of this study was to investigate epigenetic and genetic regulation of oxytocin receptor (OXTR), dopamine transporter (DAT1) and serotonin transporter (SERT) genes using DNA obtained from saliva samples of young university students: the Internet Addiction Test (IAT) was administered to evaluate the potential existence and intensity of IA. Significant changes in DNA methylation levels at OXTR, DAT1 and SERT genes were observed in the 30<29 subjects (complete control of internet use) and IAT>50 subjects (considered as moderately addicted). Moreover, epigenetic markers were significantly correlated, either directly (for OXTR and DAT1) or inversely (OXTR and DAT1 versus SERT), to the psychometric properties. Our data confirmed the involvement of OXTR, DAT1 and SERT genes in processes related to behavioural addictions and might be of relevance to suggest possible biological predictors of altered behaviours and the eventual vulnerability to develop an IA. Different other genetic pathways have been suggested to play a role in IA and research is ongoing to better define them, in order to help in the early diagnosis as well as in the development of new potential treatments.
Selenium in the treatment of mild-to-moderate Graves’ orbitopathy: A 5-year Prospective Controlled Cohort Study
Authors: Wang Chuyuan , Qiao Jing , Liu Shanshan , Piao Sichen , Zhou Yun , Hu Yuedong , Wan Chao , Sun Yizhou , Ning Hong , Chen Lei , Zhang He , Hu Ruolin , Wang Haoyu , Wang Weiwei , Zhao Lei , Mao Jinyuan , Li Min , Teng Weiping , Shan Zhongyan , Li Yushu 
Published: November 2023

Abstract
Purpose
Graves’ orbitopathy (GO) is the main extrathyroidal manifestation of Graves’ disease. However, limited studies have investigated the actual efficacy of selenium in GO therapy. This longitudinal study explored the effect of selenium on QOL and prognosis of patients with mild-to-moderate GO.
Methods
We conducted a 5-year prospective controlled cohort clinical trial to determine the effect of selenium on 74 patients with mild-to-moderate GO. Patients received selenium yeast or placebo orally for 6 months and were followed up at 6 months and at 5 years by biochemical examination, ophthalmologist evaluation and QOL questionnaire to assess oculopathy and QOL.
Results
(1) During a follow-up period of 3–6 months, in the selenium group, the symptoms of tearing, grittiness and conjunctival congestion improved (P < 0.01); clinical activity scores and total GO-QOL scores increased relative to baseline (P < 0.01); TRAb was decreased at the 6-month evaluation (P = 0.003); and patients treated with selenium had a higher rate of improvement and a lower rate of worsening than patients treated with placebo (P < 0.05). (2) Exploratory evaluations at 6 months after drug withdrawal confirmed the earlier results; further changes included alleviation of blurred vision and diplopia symptoms in the selenium group (P < 0.01). (3) At the 5-year follow-up, compared with baseline, ocular symptoms and signs, proptosis, clinical activity scores, TRAb level and total GO-QOL scores in both the selenium and placebo groups were significantly improved (P < 0.01).
Conclusion
Six months of selenium supplementation may effectively change the early course of mild-to-moderate GO, but this regimen makes no difference in long-term outcomes.
The overall decomposition of the spring-detached litter is faster than the autumn-detached litter in a steppe ecosystem
Authors: Wang Yanan , Xing Pengfei , Cheng Jianwei , Wang Ning , Wang Yadong , Wu Lin , Suri Guga , Li Frank Yonghong 
Published: November 2023

Abstract
In the grasslands, a large proportion of plant shoots senesces into standing dead materials in autumn and stays over the winter period instead of becoming detached litter immediately. However, the information on the decomposition of plant standing dead materials during the winter period and its impacts on their subsequent decomposition after littering in coming spring remain unavailable. We conducted a two-year experiment in Inner Mongolia to compare the decomposition process of the litters detached in autumn versus that detached in spring of two dominant plant Leymus chinensis and Stipa grandis. Throughout the whole decomposition period, the autumn litter was directly positioned upon the soil surface, while the spring litter suspended as standing dead for the first 7 months of winter before being detached. We found that the overall decomposition rate of spring litter was faster than the autumn litter over the experimental period. The decomposition rate was correlated positively with the N content, but negatively with the C/N ratio, lignin concentration and lignin/N ratio in litters. The spring litter showed a sharp decrease in lignin remaining during the standing-dead stage, while the autumn litter did not, which suggests an important role of photodegradation in the breakdown of lignin over the winter period that facilitates the litter decomposition in subsequent stages. These findings highlight the difference in the decomposition rates of the litters detached in autumn versus in spring, and suggest to incorporate the effects of the standing-dead stage in calculating or modeling the nutrient turnover rates in semi-arid steppe ecosystems.
Phenotypic and yield responses of common bean (Phaseolus vulgaris l.) varieties to different soil moisture levels
Authors: Geleta Refisa Jebessa , Roro Amsalu Gobena , Terfa Meseret Tesema 
Published: November 2023

Abstract
Background:Morphologicalplasticity is one of the capacities of plants to modify their morphological appearance in response to external stimuli. However, such phenotypic expression varies among different varieties based on their levels of particular environmental stress conditions. However, the morphological and yield responses of common bean varieties to different environmental conditions are not well known.
Methods: A pot experiment was carried out to investigate the effects of different moisture levels on the phenotypic and yield responses of common bean varieties. A factorial combination of five common bean varieties (Hirna, kufanzik, Awash-1, Ado, and Chercher) and three moisture levels (control, waterlogging stress, and moisture deficit stress) was used in three replications. Moisture stress treatments were started 20 days after planting, at the trifoliate growth stage. To evaluate the response of each variety, morphological and yield data were collected at week intervals.
Main Results:The resultsindicated that moisture levels and varieties had a significant influence on all growth parameters. Crop phenology was significantly influenced by the interaction effect of moisture level and variety. Exposing Hirna variety to moisture stress led to extended flowering and pod setting by 23 and 24 days, respectively, compared to the other treatments. The results showed that the phenotypic responses to moisture deficit and waterlogging stress varied between varieties. Waterlogging stress had a stronger reduction effect on the fresh weight, dry weight and leaf area of common bean varieties than moisture deficit andthe control. Pods per plant, seeds per plant, grain yield per plant, and harvest index were significantly influenced by the varieties, moisture stress levels and their interaction. Except for Chercher and Hirna. However, varieties Ado, kufanzik and Awasha-1 did not show significant differences onthe time of flower initiation due to moisture level. Biomass and growth in leaf fresh weight, leaf dry weight, leaf area, leaf number and plant height were significantly influenced by moisture level. When moisture deficit and waterlogging stress occurred, Ado and Awash-1 were more responsive to moisture stress than Hirna, Chercher, and Kufanzik.
Conclusion: Hence, Hirna and Kufanzik varieties were found to be tolerant because they produced higher yields than the Chercher, Awash-1, and Ado varieties.
Impacts of cattle management and agricultural practices on water quality through different approaches: physicochemical and ecotoxicological parameters
Authors: Peluso Julieta , Chehda Agostina Martínez , Olivelli Melisa S , Ivanic Federico M , Butler Matías , Aparicio Virginia , De Geronimo Eduardo , Gonzalez Florencia , Valenzuela Lautaro , Candal Roberto J , Aronzon Carolina M 
Published: November 2023

Abstract

The intensification of livestock farming can pose risks to the environment due to the increased use of veterinary products and the generation of waste in confined areas. The quality of water bodies near livestock establishments (Areco river (A) and Doblado stream (D), San Antonio de Areco, Buenos Aires, Argentina) was studied by physicochemical parameters, metals, pesticides, emerging contaminants, and lethal and sublethal toxicity (neurotoxicity and oxidative stress) in larvae of the native amphibian Rhinella arenarum. Six sites were selected: upstream (S1A and S1D), at the level of (S2A and S2D), and downstream (S3A and S3D) from the establishments. A low concentration of dissolved oxygen was observed in Doblado stream (<2.34 mg/L). Cu, Mn, V, and Zn exceeded the limits for the protection of aquatic life at various sites. Between 24 and 34 pesticides were detected in all sites, with 2,4-D, atrazine, and metolachlor being the most recurrent. In water and sediment, the concentrations of ivermectin (S2A: 1.32 μg/L and 58.18 μg/kg; S2D: 0.8 μg/L and 85.22 μg/kg) and oxytetracycline (S2A: <1 mg/L and <1 mg/kg; S2D: 11.8 mg/L and 39 mg/kg) were higher at sites near the establishments. All sites caused between 30 and 38.3% of lethality and produced neurotoxicity and alterations in the reduced glutathione content. Also, larvae exposed to samples from all sites incorporated ivermectin. These results demonstrate the degradation of the studied sites in relation to the agricultural activities of the area, highlighting the need to take measures to protect and preserve aquatic ecosystems.
Effect of two types of wall matrix on viability of lactobacillus plantarum under simulated gastrointestinal fluids
Authors: Kareem R. A. , Razavi Seyed Hadi , Mousavi ZE. 
Published: November 2023

Abstract

The viability of probiotic cells decreases during passage through the gastrointestinal tract and storage. Thus, to protect probiotics strains against harsh conditions, it is necessary to encapsulate them. Lactobacillus plantarum was entrapped in Sodium Alginate/Chitosan (SA/Chi) and Sodium Alginate/ Nano-Chitosan (SA/NChi) wall materials. SA/Chi and SA/NChi beads under FE-SEM were spherical and morphologically compact with the appearance of a crack for the SA/NChi beads. The survival rate of free cells rapidly reduced during 240 min in simulated gastrointestinal fluids and reached 29%, furthermore, the survival of bacterial cells in SA/Chi and SA/NChi beads after exposure to Simulated Stomach Fluid (SSF) and Simulated Intestinal Fluid (SIF) for 240 min was 81.61% and 87.04% respectively. Coating bacteria cells in encapsulants improved the survivability of the cells under adverse environmental conditions. At the same time, the hydrogel beads were characterized by FT-IR and DSC. The vigorous electrostatic interaction between sodium alginate and nanochitosan as well as, the high melting point for nano-chitosan resulted in a higher melting point for SA/NChi beads. The distinctive properties possessed by the SA/NChi coating make it an excellent candidate for use in food processing and as polymeric carrier in probiotics delivery system.
Discrepancies in Obesity-Related Medical Problems Between Indian and Greek Bariatric Candidates – An Observational Study.
Authors: Pantelis Athanasios G. , Kosta Susmit , Sinha Nirupam , Mathur Winnie , Lapatsanis Dimitris P. , Bhandari Mohit 
Published: November 2023

Abstract
Introduction
Obesity has been characterized as a pandemic, nevertheless, it demonstrates phenotypical and epidemiological heterogeneity across different ethnic populations.
Methods
We compared Indian and Greek patients living with obesity who presented for metabolic bariatric surgery (MBS) from 1/1/2022–31/12/2022, based on their preoperative workup. The items examined were age, sex, smoking status, preoperative body mass index (BMI), and common obesity-related medical problems (ORMPs), including hypertension, type 2 diabetes mellitus (T2DM), dyslipidemia, and obstructive sleep apnea (OSA). Categorical data are presented as frequencies (%), and continuous data as means ± SD (range). The groups were compared with Fisher’s exact test (categorical) and unpaired t-test (continuous).
Results
The Indian cohort comprised 2,093 patients (44.3% females) and the Greek 143 patients (61.5% females). Indian candidates for MBS were older (44.1 vs. 39.5 years, 95%CI 2.77–6.83, p < 0.0001) and featured lower preoperative BMI [42.1 vs. 46.7 kg/m2, 95%CI (-6.16)–(-3.04), p = 0.0001]. Smoking was more prevalent in Greeks (37.1% vs. 5.9%, 95%CI 23.2–39.1, p < 0.0001]. No significant difference was observed regarding hypertension [39.7% vs. 35.0%, 95%CI (-3.4)–12.8, p = 0.2888]. The rest of ORMPs were more prevalent in the Indian cohort (T2DM: 33.2% vs. 13.3%, 95%CI 14.0–25.8, p < 0.0001; dyslipidemia 25.4% vs. 14.7%, 95%CI 4.6–16.8, p = 0.0035; OSA: 64.0% vs. 18.9%, 95%CI 38.4–51.9, p < 0.0001).
Conclusions
Indian candidates for MBS were more likely to suffer from ORMPs compared to Greek candidates. Conversely, it could be postulated that Indian bariatric candidates had a stronger metabolic component as the indication for surgery, whereas Greek presented primarily for weight loss.
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation
Authors: Gao Yue , Zhou Wei , Zhang Pengfei , Yang Ju , Liu Xiong , Huang Congshu , Tao Yuandong , Shen Pan , Xiao Chengrong , Zhou Lei , Li Gaofu , Zhang Li 
Published: November 2023

Abstract

Keratinocyte proliferation and differentiation in epidermis are well controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a characteristic feature of major human skin diseases such as psoriasis and squamous cell carcinoma. However, the effect of keratinocyte metabolism on proliferation and differentiation remains largely elusive. We show here that the gluconeogenic enzyme fructose 1, 6-bisphosphatase 1 (FBP1) promotes differentiation while inhibits proliferation of keratinocyte and suppresses psoriasis development. FBP1 is identified among the most upregulated genes induced by UVB using transcriptome sequencing and is elevated especially in upper epidermis. FBP1 heterozygous mice exhibit aberrant epidermis phenotypes with local hyperplasia and dedifferentiation. Loss of FBP1 promotes proliferation and inhibits differentiation of keratinocytes in vitro. Mechanistically, FBP1 loss facilitates glycolysis-mediated acetyl-CoA production, which increases histone H3 acetylation at lysine 9, resulting in enhanced transcription of proliferation genes. We further find that the expression of FBP1 is dramatically reduced in human psoriatic lesions and in skin of mouse imiquimod psoriasis model. FBP1 deficiency in mice facilitates psoriasis development through glycolysis and acetyl-CoA production. Collectively, our findings reveal a previously unrecognized role of FBP1 in epidermal homeostasis and provide evidence for FBP1 as a metabolic psoriasis suppressor.
Perceived Stigma of Hereditary Chronic Diseases in Oman
Authors: Alkalbani Ali , Alharrasi Maryam , Natarajan Jansi , Aldiabat Khaldoun , Badi Ammar Al , Alrumhi Amjad , Alqassabi Khalid , Alamr Nawal Alamri , Alomari Omar 
Published: November 2023

Abstract

Background: Stigma is an experienced or anticipated social practice or negative labeling described as the blame or rejection of a person or group of people. Chronic diseases such as HIV/AIDS could result in stigma and contribute to negative health outcomes. An individual with chronic disease may experience public stigma from family members, coworkers, friends, or healthcare staff, which can lead to group separations. This study aims to describe the anticipated stigma of hereditary chronic diseases among university students. Stigma is negative labeling described as the blame or rejection of a person or group of people.
Methods: A cross-sectional study was performed on university students aged 18-30 years via a self-administered questionnaire. A total of 407 students completed the survey. The majority (93.9%) of respondents were male, and 42.5% were 21 to 24 years of age.
Results: We found that the majority (63.1%) of participants anticipated stigma with hereditary chronic diseases. Those who do not suffer from genetic diseases have a higher anticipated stigma than those who do suffer from genetic diseases. The highest mean scores were in the category of coworkers and employers (M=9.55±2.994), followed by the health care providers (M=9.15±3.433). The lowest scores were for family and friends (M=8.46±2.935). Students who did not suffer from genetic diseases (F (1,404) =4.328, p=.038), students who were unaware of the premarital screening (PMS) (F (2,402) =3.385, p=.035), and those who were unwilling to undergo PMS (F (1,405) =9.342, p=.002) showed higher stigma scores.
Conclusions: Providing supportive help for individuals with hereditary chronic illnesses is imperative and needs to be incorporated within their plan of care. Further studies are needed to investigate all these factors and how they are related to the stigma of chronic diseases.