bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable future bonds: Boosting multilateral development banks lending and improving the global reserve system
Authors: Zucker‐Marques Marina , Gallagher Kevin P. 
Published: December 2023

AbstractMultilateral development banks (MDBs) are crucial players to finance a greener, more socially inclusive and sustainable future, given their unique financial model that provides low‐cost and long‐term investments in areas aligned with the Sustainable Development Goals (SDGs) and the Paris Climate commitments. To fulfill their potential, MDBs need a stepwise increase in financing, which has been a challenge given the reluctance of their shareholders to provide additional paid‐in capital. We present a novel proposal for MDB hybrid capital that is designed to boost MDB funding while supplying the international reserve system with a new safe asset, the Sustainable Future Bonds (SFB). Under the SFB proposal, a tiny fraction of the global foreign reserves would be rechanneled to MDBs, and given liquidity enhanced mechanisms, SFB would serve as an additional safe reserve asset for central banks' portfolios. As our conservative estimation shows, by deploying just 0.5 percent of global foreign reserves for the Sustainable Future Bonds, at least $45 billion per year in fresh capital to MDBs would be mobilized. At that pace, by 2030, MDBs will have $360 billion in capital injections, which, depending on their leverage capacity, could result in new lending from $1.6 trillion to $1.9 trillion.
Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction
Authors: Roach Alexis N. , Bhadsavle Sanat S. , Higgins Samantha L. , Derrico Destani D. , Basel Alison , Thomas Kara N. , Golding Michael C. 
Published: December 2023

AbstractBackgroundChronic preconception paternal alcohol use adversely modifies the sperm epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of exposed males. A crucial outstanding question in the field of paternal epigenetic inheritance concerns the resilience of the male germline and its capacity to recover and correct sperm‐inherited epigenetic errors after stressor withdrawal.ObjectivesWe set out to determine if measures of the sperm‐inherited epigenetic program revert to match the control treatment 1 month after withdrawing the daily alcohol treatments.Materials and methodsUsing a voluntary access model, we exposed C57BL/6J males to 6% or 10% alcohol for 10 weeks, withdrew the alcohol treatments for 4 weeks, and used RNA sequencing to examine gene expression patterns in the caput section of the epididymis. We then compared the abundance of sperm small RNA species between treatments.ResultsIn the caput section of the epididymis, chronic alcohol exposure induced changes in the transcriptional control of genetic pathways related to the mitochondrial function, oxidative phosphorylation, and the generalized stress response (EIF2 signaling). Subsequent analysis identified region‐specific, alcohol‐induced changes in mitochondrial DNA copy number across the epididymis, which correlated with increases in the mitochondrial DNA content of alcohol‐exposed sperm. Notably, in the corpus section of the epididymis, increases in mitochondrial DNA copy number persisted 1 month after alcohol cessation. Analysis of sperm noncoding RNAs between control and alcohol‐exposed males 1 month after alcohol withdrawal revealed a ∼100‐fold increase in mir‐196a, a microRNA induced as part of the nuclear factor erythroid 2‐related factor 2 (Nrf2)‐driven cellular antioxidant response.Discussion and conclusionOur data reveal that alcohol‐induced epididymal mitochondrial dysfunction and differences in sperm noncoding RNA content persist after alcohol withdrawal. Further, differences in mir‐196a and sperm mitochondrial DNA copy number may serve as viable biomarkers of adverse alterations in the sperm‐inherited epigenetic program.
Classification Shifting and Future Stock Price Crash Risk
Authors: Hwang Juhee , Lee Cheol , Nam Giman 
Published: December 2023

AbstractWe examine whether classification shifting is associated with stock price crash risk. Unlike prior studies, our study is focused on bad news hoarding through classification shifting. Prior studies document evidence of the greater weight market participants place on core earnings and stock price crash resulting from delayed bad news releases. Building upon these findings, we predict that crash risk is positively associated with shifters’ reversal of core earnings. Consistent with our conjecture, we find that classification shifting is positively associated with future stock price crash risk even if the bottom‐line net income is unchanged. This finding is robust after controlling for endogeneity and other determinants of classification shifting. We also find that the observed positive association between classification shifting and future stock price crash risk is pronounced for likely opportunistic classification shifters. Our research contributes to forming an enhanced understanding of crash risk by documenting differential negative market reactions to the change in core earnings driven by classification shifting.
The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism
Authors: Sun Yuqing , Zhang Luyong , Jiang Zhenzhou 
Published: December 2023

AbstractBile acids are synthesized from cholesterol in the liver. Dysregulation of bile acid homeostasis, characterized by excessive accumulation in the liver, gallbladder and blood, can lead to hepatocellular damage and the development of cholestatic liver disease. Nuclear receptors play a crucial role in the control of bile acid metabolism by efficiently regulating bile acid synthesis and transport in the liver. Among these receptors, peroxisome proliferator‐activated receptor (PPAR), a ligand‐activated transcription factor belonging to the nuclear hormone receptor superfamily, controls the expression of genes involved in adipogenesis, lipid metabolism, inflammation and glucose homeostasis and has emerged as a potential therapeutic target for the treatment of the metabolic syndrome in the past two decades. Emerging evidence suggests that PPAR activation holds promise as a therapeutic target for cholestatic liver disease, as it affects both bile acid production and transport. This review provides a comprehensive overview of recent advances in elucidating the role of PPAR in the regulation of bile acid metabolism, highlighting the current position of PPAR agonists in the treatment of primary biliary cholangitis. By summarizing the specific regulatory effects of PPAR on bile acids, this review contributes to the exploration of novel therapeutic strategies for cholestatic liver diseases.
The impact of conspiracy beliefs on a targeted group: Perceived popularity of Jewish‐targeted conspiracy beliefs elicits outgroup avoidant behaviours
Authors: Jolley Daniel , Paterson Jenny L. , McNeill Andrew 
Published: December 2023

AbstractIn three studies with Jewish participants, we explored the consequences of intergroup conspiracy theories on those targeted. In Study 1 (N = 250), perceived Jewish conspiracy theory popularity was positively associated with intergroup threat and negatively associated with the closeness of contact with non‐Jewish people. Study 2 (n = 194) employed an experimental design where Jewish participants were exposed to the idea that many (vs. few) non‐Jewish people believe in Jewish conspiracy theories. A path model demonstrated that exposure to the many (vs. few) manipulation increased intergroup threat, which was then positively associated with emotional reactions. Intergroup anxiety and ingroup anger were then positively associated with avoidance, whilst ingroup anxiety was positively associated with approach tendencies. Study 3 (n = 201) used the same experimental design, and a path model revealed that conspiracy popularity increased intergroup threat, which, in turn, was positively associated with ingroup anger and anxiety. Ingroup anxiety was then associated with intentions to help ingroup members. Notably, conspiracy popularity rendered participants less likely to interact with a non‐Jewish partner in a behavioural task. Our work provides evidence that conspiracy beliefs, especially when perceived to be widely held, are likely to significantly impact targeted ingroup members.
Piezo1‐mediated regulation of smooth muscle cell volume in response to enhanced extracellular matrix rigidity
Authors: Johnson Robert T. , Solanki Reesha , Wostear Finn , Ahmed Sultan , Taylor James C. K. , Rees Jasmine , Abel Geraad , McColl James , Jørgensen Helle F. , Morris Chris J. , Bidula Stefan , Warren Derek T. 
Published: December 2023

AbstractBackground and PurposeDecreased aortic compliance is a precursor to numerous cardiovascular diseases. Compliance is regulated by the rigidity of the aortic wall and the vascular smooth muscle cells (VSMCs). Extracellular matrix stiffening, observed during ageing, reduces compliance. In response to increased rigidity, VSMCs generate enhanced contractile forces that result in VSMC stiffening and a further reduction in compliance. Mechanisms driving VSMC response to matrix rigidity remain poorly defined.Experimental ApproachHuman aortic‐VSMCs were seeded onto polyacrylamide hydrogels whose rigidity mimicked either healthy (12 kPa) or aged/diseased (72 kPa) aortae. VSMCs were treated with pharmacological agents prior to agonist stimulation to identify regulators of VSMC volume regulation.Key ResultsOn pliable matrices, VSMCs contracted and decreased in cell area. Meanwhile, on rigid matrices VSMCs displayed a hypertrophic‐like response, increasing in area and volume. Piezo1 activation stimulated increased VSMC volume by promoting calcium ion influx and subsequent activation of PKC and aquaporin‐1. Pharmacological blockade of this pathway prevented the enhanced VSMC volume response on rigid matrices whilst maintaining contractility on pliable matrices. Importantly, both piezo1 and aquaporin‐1 gene expression were up‐regulated during VSMC phenotypic modulation in atherosclerosis and after carotid ligation.Conclusions and ImplicationsIn response to extracellular matrix rigidity, VSMC volume is increased by a piezo1/PKC/aquaporin‐1 mediated pathway. Pharmacological targeting of this pathway specifically blocks the matrix rigidity enhanced VSMC volume response, leaving VSMC contractility on healthy mimicking matrices intact. Importantly, upregulation of both piezo1 and aquaporin‐1 gene expression is observed in disease relevant VSMC phenotypes.
CAMTA1‐related disorder: Phenotypic and molecular characterization of 26 new individuals and literature review
Authors: Al‐Kateb Hussam , Au P. Y. Billie , Berland Siren , Cogne Benjamin , Demurger Florence , Fluss Joel , Isidor Bertrand , Frank L. Matthew , Varvagiannis Konstantinos , Koolen David A. , McDonald Marie , Montgomery Sarah , Moortgat Stéphanie , Deprez Marie , Karadurmus Deniz , Paulsen Julie , Reis André , Rieger Melissa , Vasileiou Georgia , Willing Marcia , Shinawi Marwan 
Published: December 2023

AbstractCalmodulin‐binding transcriptional activator 1 (CAMTA1) is highly expressed in the brain and plays a role in cell cycle regulation, cell differentiation, regulation of long‐term memory, and initial development, maturation, and survival of cerebellar neurons. The existence of human neurological phenotypes, including cerebellar dysfunction with variable cognitive and behavioral abnormalities (CECBA), associated with CAMTA1 variants, has further supported its role in brain functions. In this study, we phenotypically and molecularly characterize the largest cohort of individuals (n = 26) with 23 novel CAMTA1 variants (frameshift‐7, nonsense‐6, splicing‐1, initiation codon‐1, missense‐5, and intragenic deletions‐3) and compare the findings with all previously reported cases (total = 53). We show that the most notable phenotypic findings are developmental delay/intellectual disability, unsteady or uncoordinated gait, hypotonia, behavioral problems, and eye abnormalities. In addition, there is a high incidence of dysarthria, dysgraphia, microcephaly, gastrointestinal abnormalities, sleep difficulties, and nonspecific brain MRI findings; a few of which have been under‐reported. More than one third of the variants in this cohort were inherited from an asymptomatic or mildly affected parent suggesting reduced penetrance and variable expressivity. Our cohort provides a comprehensive characterization of the spectrum of phenotypes and genotypes among individuals with CECBA and the large data will facilitate counseling and formulating management plans and surveillance recommendations for these individuals.
Rent seeking and precautionary bidding in conservation auctions
Authors: Wichmann Bruno 
Published: December 2023

AbstractThe paper presents a model to study reverse auctions for conservation contracts. A buyer elicits bids from multiple rent seeking and risk averse farmers. Conservation activities have ex post cost risk such that farmers only learn the true value of conservation contracts after the auction. The paper derives the optimal bidding function and shows that farmers have conflicting incentives when facing multiple sources of risk. Specifically, we show that farmers exhibit a form of precautionary bidding, that is, they increase their bids in response to an increase in valuation risk. We propose an approach to take the model to the data and recover structural risk parameters. The suitability of the approach to real‐world data is demonstrated through a Monte Carlo experiment.
US‐based and international environmental nongovernmental organizations use social media, but few have large audiences online
Authors: Kim Hanna , Armsworth Paul R. , Masuda Yuta J. , Chang Charlotte H. 
Published: December 2023

AbstractSocial media plays an outsized role in information dissemination, issue mobilization, and public influence. For environmental nongovernmental organizations (“eNGOs”), social media plays a critical role in fundraising and inspiring engaged audiences using rich media and punchy taglines. Yet, there is little to no accounting of whether and how eNGOs have adopted social media, limiting analyses of how eNGOs are leveraging social media to develop effective communication strategies and campaigns. We analyzed the social media presence of over 100 eNGOs. We evaluated which platforms are used by eNGOs and differences between them in terms of their visibility on social media. 88%–97% of the eNGOs in our sample use four out of the five leading social media platforms. There were marked differences across eNGOs and platforms in terms of public visibility, represented by the number of followers. eNGOs focusing on advocacy, aquatic environments, and species conservation had significantly larger numbers of followers. Our findings indicate that conservation can make more headway on newer, more visually‐oriented platforms that also have stronger youth traction. We use our analyses to identify which eNGOs have much larger followings on social media than expected. These leaders can provide lessons on how eNGOs can enhance their social media impact.
Changes in decision‐making function in patients with subacute mild traumatic brain injury
Authors: Wang Yuyang , Chen Qing , Zhang Xinyu , Wang Kai , Cheng Hongwei , Chen Xingui 
Published: December 2023

AbstractAlthough awareness regarding patients with mild traumatic brain injury has increased, they have not received sufficient attention in clinics; hence, many patients still experience only partial recovery. Deficits in decision‐making function are frequently experienced by these patients. Accurate identification of impairment in the early stages after brain injury is particularly crucial for timely intervention and the prevention of long‐term cognitive consequences. Therefore, we investigated the changes in decision‐making ability under tasks of ambiguity and risk in patients with mild traumatic brain injury with a rule‐based neuropsychological paradigm. In this study, patients (n = 39) and matched healthy controls (n = 38) completed general neuropsychological background tests and decision‐making tasks (Iowa Gambling Task and Game of Dice Task). We found that patients had extensive cognitive impairment in general attention, memory and information processing speed in the subacute phase, and confirmed that patients had different degrees of impairment in decision‐making abilities under ambiguity and risk. Furthermore, the decline of memory and executive function may be related to decision‐making dysfunction.
Optimizing job shop scheduling with speed‐adjustable machines and peak power constraints: A mathematical model and heuristic solutions
Authors: Homayouni S. Mahdi , Fontes Dalila B.M.M. 
Published: December 2023

AbstractThis paper addresses a job shop scheduling problem with peak power constraints, in which jobs can be processed once or multiple times on either all or a subset of the machines. The latter characteristic provides additional flexibility, nowadays present in many manufacturing systems. The problem is complicated by the need to determine both the operation sequence and starting time as well as the speed at which machines process each operation. Due to the adherence to renewable energy production and its intermittent nature, manufacturing companies need to adopt power‐flexible production schedules. The proposed power control strategies, that is, adjusting processing speed and timing to reduce peak power requirements may impact production time (makespan) and energy consumption. Therefore, we propose a bi‐objective approach that minimizes both objectives. A linear programming model is developed to provide a formal statement of the problem, which is solved to optimality for small‐sized instances. We also proposed a multi‐objective biased random key genetic algorithm framework that evolves several populations in parallel. Computational experiments provide decision and policymakers with insights into the implications of imposing or negotiating power consumption limits. Finally, the several trade‐off solutions obtained show that as the power limit is lowered, the makespan increases at an increasing rate and a similar trend is observed in energy consumption but only for very small makespan values. Furthermore, peak power demand reductions of about 25% have a limited impact on the minimum makespan value (4–6% increase), while at the same time allowing for a small reduction in energy consumption.
Under the shadow of the future: Gender‐specific reactions to (un)certain future interactions
Authors: Kleinknecht Janina , Ulmer Clara 
Published: December 2023

AbstractExpectations are a key element of strategic environments. As it has already been shown that men's performance in current competitions is affected by the expected future opponents' strength, we investigate whether women are overshadowed by future competitors as well. We use data from professional tennis, replicate the results for men and compare it with women's behavior. Extending previous research, we focus on the role of uncertainty in this context, particularly, whether behavior differs when individuals have to form expectations instead of having accurate information. Our results suggest that individuals perform worse in competitions if the expected future opponent is stronger. We find gender‐specific behavior when analyzing uncertainty as a potential source: Women's current performance does not depend on the future competitor's strength when they know her for sure, whereas they are overshadowed when having to form expectations. In contrast, men are negatively affected by the future competitor's strength when they know him and when they need to form expectations. Moreover, women (men) rather seem to be sensitive to direct (more distant) incentives. These findings might be transferred to information revelation in promotion contests to help highly qualified individuals, especially women, climb the career ladder.
Exploring food safety knowledge, attitudes, and practices of nursing and medical students: Insights from a cross‐sectional study in Bangladesh
Authors: Roy Nitai , Mollick Kakali , Siddiky Aysha , Aktarujjaman Md. , Hossain Ekhtear , Islam Farhadul , Kumar Manasi 
Published: December 2023

AbstractThis study focuses on nursing and medical students, assessing their knowledge, attitudes, and practices (KAP) regarding food safety. This non‐random cross‐sectional study was conducted between October and December 2022, with 1100 students (721 nursing and 379 medical) completing self‐administered questionnaires. 949 (86.3%) of the respondents were female and 151 (13.7%) were male (mean age 20.90 ± 1.74). Nursing students outperformed medical students in food safety KAP scores (19.45 ± 3.19 vs. 19.13 ± 3.36), (10.61 ± 1.52 vs. 10.27 ± 1.80), and (46.96 ± 6.48 vs. 42.87 ± 6.49), with significant differences in food safety attitudes and practices (p < 0.05), as well as knowledge regarding personal hygiene, food preparation, cooking, foodborne pathogens, and cross‐contamination (p < 0.05). Multivariate stepwise linear regression analysis revealed predictors of food safety knowledge, including age, residence, academic year, personal food poisoning experience, and familiarity with food safety authority (p < 0.05). Similarly, institutional context, gender, income, residential status, academic year, personal cooking habit, father's education level, and mother's education level had a substantial impact on the attitudes of students. Predictors of safe food handling practices encompassed institutional context, age, gender, family monthly income, residential status, academic year, father's education level, personal food poisoning experience, and familiarity with food safety authority (p < 0.05). These findings highlighted the need for targeted educational interventions to improve food safety KAP among nursing and medical students considering their forthcoming responsibilities as carers.
Let My People In: Jewish Ethiopian Histories and the Israeli Zionist Canon, 1984–2004
Authors: Tal Nimrod 
Published: December 2023

AbstractThis article explores the significance of Jewish‐Ethiopian historical narratives for the understanding of Ethiopian Jews' social reality in Israel. It emphasizes how these narratives have been crucial for the ongoing integration efforts of the Jewish Ethiopian community, especially during a period of significant challenges to the established Zionist historical canon. By analysing extensive archival sources, the study uncovers the grassroots emergence of these narratives, shaped by debates surrounding the position of Ethiopian immigrants in Israeli society. It demonstrates that the inclusion of historical perspectives not only strengthened the canonical Zionist historical narrative but also enabled it to withstand unprecedented challenges. This challenges the notion that immigration and social diversification undermine dominant historical canons and national identities. The research underscores the relevance of these historical narratives in revealing the experiences and struggles of Ethiopian Jews and their unique place within Israel's social fabric.