bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERBB2 (HER2) amplifications and co-occurring KRAS alterations in the circulating cell-free DNA of pancreatic ductal adenocarcinoma patients and response to HER2 inhibition
Authors: Barzi Afsaneh , Weipert Caroline M. , Espenschied Carin R. , Raymond Victoria M. , Wang-Gillam Andrea , Nezami Mohammad Amin , Gordon Eva J. , Mahadevan Daruka , Mody Kabir 
Published: February 2024

PurposeDespite accumulating data regarding the genomic landscape of pancreatic ductal adenocarcinoma (PDAC), olaparib is the only biomarker-driven FDA-approved targeted therapy with a PDAC-specific approval. Treating ERBB2(HER2)-amplified PDAC with anti-HER2 therapy has been reported with mixed results. Most pancreatic adenocarcinomas have KRAS alterations, which have been shown to be a marker of resistance to HER2-targeted therapies in other malignancies, though the impact of these alterations in pancreatic cancer is unknown. We describe two cases of ERBB2-amplified pancreatic cancer patients treated with anti-HER2 therapy and provide data on the frequency of ERBB2 amplifications and KRAS alterations identified by clinical circulating cell-free DNA testing.MethodsDe-identified molecular test results for all patients with pancreatic cancer who received clinical cell-free circulating DNA analysis (Guardant360) between 06/2014 and 01/2018 were analyzed. Cell-free circulating DNA analysis included next-generation sequencing of up to 73 genes, including select small insertion/deletions, copy number amplifications, and fusions.ResultsOf 1,791 patients with pancreatic adenocarcinoma, 36 (2.0%) had an ERBB2 amplification, 26 (72.2%) of whom had a KRAS alteration. Treatment data were available for seven patients. Two were treated with anti-HER2 therapy after their cell-free circulating DNA result, with both benefiting from therapy, including one with a durable response to trastuzumab and no KRAS alteration detected until progression.ConclusionOur case series illustrates that certain patients with ERBB2-amplified pancreatic adenocarcinoma may respond to anti-HER2 therapy and gain several months of prolonged survival. Our data suggests KRAS mutations as a possible mechanism of primary and acquired resistance to anti-HER2 therapy in pancreatic cancer. Additional studies are needed to clarify the role of KRAS in resistance to anti-HER2 therapy.
Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS
Authors: Wei Xinyi , Su Yanding , Cheng Qian , Liang Songmao , Zhang Tingping , Duan Lengxin , Shen Xiuwei , Qiu Xiangjun 
Published: February 2024

Objective: A remarkably sensitive, accurate, and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was developed as a facile and expeditious method for measuring cilofexor concentration in beagle dogs, the herb-drug interactions between silybinin and cilofexor was explored based on pharmacokinetics.Methods: The plasma sample protein of the beagles were rapidly sedimented with acetonitrile, and cilofexor and tropifexor (internal standard, ISTD) were separated by gradient elution using a 0.1% formic acid aqueous solution and acetonitrile as the mobile phase. The concentrations were detected using positive ion multiple reaction monitoring (MRM) mode. Mass transfer pairs were m/z 587.91→267.91 for cilofexor and m/z 604.08→228.03 for ISTD, respectively. A two-period self-controlled experimental design was adopted for the HDIs experiment. In the first period (Group A), six beagle dogs were orally administered cilofexor at a dose of 1 mg/kg. In the second period (Group B), silybinin (3 mg/kg) was orally administered to the six beagle dogs twice a day for seven consecutive days, after which cilofexor was orally administered. The cilofexor concentration in beagle dogs was determined, and HDIs were evaluated based on their pharmacokinetics.Results: The accuracy and precision of cilofexor were both less than 15%, and the recoveries, matrix effects, and stability met the relevant requirements. The Cmax of cilofexor in group B was 49.62% higher than that in group A, whereas the AUC(0-t) and AUC(0−∞) of cilofexor in group B were 47.85% and 48.52% higher, respectively, than those in group A. Meanwhile, the t1/2 extended from 7.84 h to 9.45 h, CL and Vz decreased in Group B.Conclusion: A novel UPLC-MS/MS approach was successfully applied for the measurement of cilofexor in beagle dog plasma. Silybinin can alter the pharmacokinetics of cilofexor in beagle dogs, thereby increasing plasma exposure to cilofexor.
Research on intrusion and large arch bulge in lining structure for highway’s mudstone tunnel
Authors: Li Shuai , Fu Jing , Liu Gengren , Zhou Jinghu 
Published: February 2024

During the construction of a highway in northwest China, large deformation of mudstone caused severe deformation of and damage to side walls, initial support, and secondary lining to various extents. To reveal the causes of mudstone’s large deformation in the tunnels of this highway, a comprehensive study was conducted by using engineering geological survey, on-site monitoring and measurement, indoor rock mechanics test, numerical simulation, and macroscopic analysis. For the problem of large deformation of this highway’s tunnel section from YK209 + 500 m to YK210 + 030 m, the 3D finite difference method FLAC3D was used to simulate the large deformation of the wall rock and compare the deformation of the tunnel and the mechanical characteristics of the lining structure under different conditions by means of inverse analysis of the rheological characteristics of the mudstone and simulation of the softening of the mudstone in water. The research results provide a reference and basis for the construction design of similar mudstone tunnel projects. For the management of tunnel deformation, it is recommended to enhance the tunnel’s drainage measures, thereby mitigating the intensification of mudstone softening when exposed to water.
Microbiome structure variation and soybean’s defense responses during flooding stress and elevated CO2
Authors: Coffman Lauryn , Mejia Hector D. , Alicea Yelinska , Mustafa Raneem , Ahmad Waqar , Crawford Kerri , Khan Abdul Latif 
Published: February 2024

IntroductionWith current trends in global climate change, both flooding episodes and higher levels of CO2 have been key factors to impact plant growth and stress tolerance. Very little is known about how both factors can influence the microbiome diversity and function, especially in tolerant soybean cultivars. This work aims to (i) elucidate the impact of flooding stress and increased levels of CO2 on the plant defenses and (ii) understand the microbiome diversity during flooding stress and elevated CO2 (eCO2).MethodsWe used next-generation sequencing and bioinformatic methods to show the impact of natural flooding and eCO2 on the microbiome architecture of soybean plants' below- (soil) and above-ground organs (root and shoot). We used high throughput rhizospheric extra-cellular enzymes and molecular analysis of plant defense-related genes to understand microbial diversity in plant responses during eCO2 and flooding.ResultsResults revealed that bacterial and fungal diversity was substantially higher in combined flooding and eCO2 treatments than in non-flooding control. Microbial diversity was soil&gt;root&gt;shoot in response to flooding and eCO2. We found that sole treatment of eCO2 and flooding had significant abundances of Chitinophaga, Clostridium, and Bacillus. Whereas the combination of flooding and eCO2 conditions showed a significant abundance of Trichoderma and Gibberella. Rhizospheric extra-cellular enzyme activities were significantly higher in eCO2 than flooding or its combination with eCO2. Plant defense responses were significantly regulated by the oxidative stress enzyme activities and gene expression of Elongation factor 1 and Alcohol dehydrogenase 2 in floodings and eCO2 treatments in soybean plant root or shoot parts.ConclusionThis work suggests that climatic-induced changes in eCO2 and submergence can reshape microbiome structure and host defenses, essential in plant breeding and developing stress-tolerant crops. This work can help in identifying core-microbiome species that are unique to flooding stress environments and increasing eCO2.
The prospective associations among time management tendency, negative emotions, and problematic smartphone use in Chinese nursing students: enlightenment from COVID-19
Authors: Ding Nani , Shi Jiaqi , Xu Huihui , Wang Xiaoyi , Liu Guilin , Mao Lijie , Zhang Guohua , Zhang Jingjing 
Published: February 2024

PurposeThe regularity of epidemic prevention and control measures in China has meant that nursing students have been exposed to more electronic devices, while problematic smartphone use has increased. The purpose of this study is to determine the prospective associations among time management tendency, negative emotions, and problematic smartphone use in nursing students during the COVID-19 pandemic.MethodsA longitudinal study was conducted between November 2021 and May 2022. A total of 989 nursing students participated. The convenience sampling method was adopted and the following tools were used: the Adolescence Time Management Disposition Scale, the Depression Anxiety Stress Scales – 21, and the Mobile Phone Addiction Index. Multiple parallel mediation models were used by Mplus.ResultsTime management tendency had a significantly negative effect on problematic smartphone use (p &lt; 0.05). Further tests using mediation models showed that stress as a negative emotion mediated the relationship between time management tendency and problematic smartphone use (p &lt; 0.05) over time.ConclusionNursing educators need to strengthen the stress resistance and time management ability of nursing students.
Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020
Authors: Atabieke Falide , Li Xiu-Juan , Aierken Ailikamu , Li Jian , Zhang Yu , Aizezi Yierzhati , Gao Hong-Liang , Zhang Zhi-Qiang 
Published: February 2024

BackgroundAlthough previous studies found that frailty is prevalent in NAFLD patients with advanced liver fibrosis and cirrhosis, studies examining the relationship are spare.AimOur study aspires to investigate the potential correlation between the Frailty Index (FI) and hepatic fibrosis among middle-aged and older adults with NAFLD.MethodsData from the 2017–2020.03 National Health and Nutrition Examination Survey (NHANES) were utilized for this study, with a final of 2,383 participants aged 50 years and older included. The quantification of frailty was executed employing a 49-item frailty index. The recognition of hepatic steatosis and fibrosis was accomplished through the utilization of the controlling attenuation parameter (CAP) and transient elastography (TE). The relationship between the FI and hepatic fibrosis were investigated employing univariable and multivariable-adjusted logistic regression analyses. A subgroup analysis was conducted, dividing the subjects based on gender, Body Mass Index (BMI), and the presence of hyperlipidemia.ResultsThe findings demonstrated a positive correlation between the FI and significant hepatic fibrosis in NAFLD, even after using multivariate logistic regression models adjusting for potential confounding factors (OR = 1.022, 95% CI, 1.004–1.041) and in tertiles (Q3vs Q1: OR = 2.004, 95% CI, 1.162–3.455). In the subgroup analysis, the correlation was more statistically significant in male (OR = 1.046, 95% CI, 1.022–1.071), under/normal weight (OR = 1.077, 95% CI, 1.009–1.150), overweight (OR = 1.040, 95% CI, 1.010–1.071), and subjects without hyperlipidemia (OR = 1.054, 95% CI, 1.012–1.097). The area under the Receiver Operating Characteristic (ROC) curve for the FI in assessing the existence of substantial fibrosis in NAFLD was 0.612 (95% CI, 0.596–0.628).ConclusionThis study demonstrated a positive correlation between significant hepatic fibrosis and frailty, particularly among males aged 50 years and older, who were non-obese and did not have hyperlipidemia with NAFLD. Additional studies are required to further validate these findings.
Eating behavior during pregnancy mediates the association between depression and diet quality--a new strategy for intervention in pregnancy
Authors: Jin Xingyi , Zhu Jian , Wang Niannian , Sun Lingzhen , Yu Junhui , Wang Shaokang , Sun Guiju 
Published: February 2024

BackgroundDepression can result in changes in eating behavior and decrease the quality of eating. It has been shown that maternal depression during pregnancy can result in malnutrition, which can have adverse effects on the pregnancy and the offspring. There is currently no clear association between depression and diet.MethodsFive hundred and forty-nine pregnant women recruited from Danyang Maternal and Child Health Hospital in Jiangsu Province participated in this study and were administered the Intuitive Eating Scale-2 (IES-2), Edinburgh Post-natal Depression Scale (EPDS), Pregnancy Stress Scale (PPS), Self-rating Anxiety Scale (SAS), and Dietary Guidelines Adherence Index for Pregnant Women during Pregnancy (CDGCI-PW). The nutritional software collected dietary records for three consecutive days in mid-pregnancy to calculate dietary intake and nutrients that support energy production. The mediation analyses were conducted using SPSS 24.0 macro PROCESS.ResultsThe relationship between depressive symptoms during pregnancy and diet quality was moderated primarily by two aspects of eating behavior, “Reliance on Hunger and Satiety Cues” (RHS) and “Body-Food Choice Congruence” (BFC). Depressive symptoms (EPDS scores) showed a negative correlation with RHS, BFC, and RHS, and BFC showed a positive correlation with diet quality, yielding a significant specific indirect effect. The multiple mediation model explained 14.7% of the variance in the diet quality.ConclusionThis study highlights the important role of eating behaviors during pregnancy in the relationship between depressive symptoms (EPDS scores) and diet quality, and provides preliminary evidence for feasible ways pregnant women with depressive symptoms can improve diet quality, promote maternal and child health, and reduce depression.
What next for behaviour change professional development in general practice? Insights from an environmental scan and workshops
Authors: Brickley Bryce , Advocat Jenny , Chai Tze Lin , Bowden Mitchell , Rieger Elizabeth , Ball Lauren , Ng Raeann , Gunatillaka Nilakshi , Sturgiss Elizabeth Ann 
Published: February 2024

Background
A key role of general practice professionals (that is, GPs, and general practice nurses [GPNs]) is to support patients to change behaviours. Traditional approaches to assisting patients with, and learning about, behaviour change have modest outcomes.

Aim
To explore behaviour change with GPs and GPNs and the availability of related professional development (PD) opportunities.

Design & setting
Multi-methods study comprising an environmental scan survey of behaviour change tools and PD opportunities, and online workshops with Australian GPs and GPNs.

Method
Survey data were analysed using qualitative content analysis, informing the design of the workshops. Workshop data included observation, note-taking, and collaborative reflection, which were analysed thematically and synthesised with survey data.

Results
The survey had 18 complete responses. For the two virtual workshops, workshop 1 had 16 participants and workshop 2 had eight participants. There was diversity in awareness of existing behaviour change tools and resources. Preferences for future tools and PD opportunities related to specific aspects of its design, content, activities, and delivery. The following three themes developed from the workshop data: recognising the importance of relationships; recognising the importance of continuity; and keeping context in mind. In the absence of tools and resources, GPs and GPNs discussed behaviour change as something that occurs best through a patient-centred alliance that is continuing, respectful, grounded in trust and an understanding of their patient, and prioritises patient autonomy.

Conclusion
Future general practice behaviour change PD should support clinicians to ‘assist’ patients and recognise the social and contextual influences on behaviour.
Evaluating the Performance of the AquaCrop Model to Soil Salinity in Jordan Valley
Authors: Hamdi Luma , Suleiman Ayman 
Published: February 2024

The demand to apply a decision support system to simulate salinity and drought is increasing with time, particularly in arid and semi-arid regions like Jordan, where the threat of land degradation by salinization is of high concern. The main objective of this research was to evaluate the response of the AquaCrop model to soil salinity in Jordan Valley. Two experiments were conducted, one at the field and the other at the greenhouse. Three water salinity levels (S): S1 (control = 2 dS m−1), S2 (4 dS m−1), and S3 (8 dS m−1) with three irrigation amounts (R): R1 (control = 120%), R2 (100%), and R3 (70%) were used in the field. Four levels of saline water (S):S1 (control =0.65), (4) S2, (8) S3, and (10) dS m-1) S4 were used in the greenhouse. In both experiments, grain yield, and aboveground biomass were measured after harvesting. Soil salinity and pH were measured every three weeks during the growing season to monitor soil salinization. Results showed that the final field grain yield was good in calibration and validation, with a 0.96 agreement index (d). The efficiency factor (E) was 0.86 and 0.87 for calibration and validation, respectively, while the normalized root mean square error (NRMSE) was less than 4 %. Field biomass d-index of 0.87 and 0.71 and E of 0.65 and 0.45 for Calibration and Validation were found, respectively. In the greenhouse experiment, the results were less satisfactory. Grain yield showed d-index of 0.84 and 0.88 in calibration and validation, respectively, while biomass showed poor results. All statistical criteria used in this research indicated that the model can simulate grain yield and biomass properly in the field, however, biomass statistical results were less accurate. Overall it is recommended, to use AquaCrop for soil salinity management in Jordan Valley.
Peramalan Stok Bahan Baku di Cafe Vosco dengan Metode SES (SINGLE EXPONENTIAL SMOOTHING) BERBASIS WEBSITE
Authors: Rafi Alfandi Farhan , Agus Pranoto Yosep , Xaverius Ariwibisono Fransiskus 
Published: February 2024

Seiring dengan perkembangan zaman, teknologi informasi menjadi salah satu alat untuk bersaing dalam bisnis, kemajuan teknologi merupakan faktor yang sangat penting dalam membantu kelancarnya kinerja dalam suatu perusahaan. Salah satu teknologi tersebut adalah sistem informasi berbasis komputer, penyampaian informasi yang cepat dapat membantu dalam pengelolaan informasi dan memberikan kemudahan dalam melaksanakan tugas sesuai bidang keahliannya.
Vosco Coffee yang berlokasi di Kota Malang merupakan toko yang menjual berbagai kopi dan makanan. Dalam perkembangan usahanya, Vosco Coffee menambah jumlah barang untuk memenuhi permintaan konsumen dan memberikan kepuasan pada konsumen. Permasalahan yang terjadi dalam mencatat, menghitung dan mengelola persediaan barang dagang yang mempengaruhi nominal pengeluaran, dan pendapatan bersih café. Terutama pada menu Vosco Coffee yang best seller atau popular.Sehingga dibutuhkan sistem peramalan agar dapat memprediksi kebutuhan bahan kopi untuk konsumen dan sesuai dengan stok yang dibutuhkan berdasarkan periode tertentu. Model untuk memprediksi kebutuhan bahan kopi untuk konsumen yaitu menggunakan model peramalan dengan metode Single Exponential Smoothing. dimana metode ini merupakan metode peramalan dengan mengadakan penghalusan atau pemulusan data masa lalu dengan mengambil rata-rata dari nilai beberapa tahun lalu untuk menaksir nilai pada tahun yang akan datang (Rahmadeni & Nurul, 2021). Output yang terjadi pada peramalan metode Single Exponential Smoothing agar dapat memberikan sistem rekomendasi keputusan untuk Cafe Vosco dan pengoperasian secara komputerisasi dengan sistem informasi. Dari data yang sudah dilakukan perhitungan menggunakan metode Single Exponential Smoothing maka didapatkan hasil keakurasian MAPE pada produk kopi Arabika 2,55%, Excelsa 2,39%, Robusta 1,85%, dan Liberica 1,97%. Sehingga dapat diketahui tingkat error tertinggi ada pada Kopi Arabica dengan 2,55%, dan tingkat error terendah pada Kopi Robusta dengan nilai 1,85% Maka dari hasil peramalan tersebut dapat dibuat kesimpulan hasil yang cukup layak dan baik.
OPTIMASI BAHAN PANGAN KECUKUPAN GIZI ATLET PANJAT TEBING MENGGUNAKAN ALGORITMA GENETIKA DENGAN METODE PROFIFEA
Authors: Kirana Ardani Erviera , Hartami Santi Indyah 
Published: February 2024

Banyak cabang olahraga yang menginginkan fisik atlet yang ideal juga menutut atlet untuk cerdas. Bisa dilihat pada negara – negara lain kondisi fisik di negara indonesia masih memerlukan pembinaan terutama pada komposisi gizi dalam aspek komposisi protein hewani, telur, susu dan daging. Sangat dibutuhkan perhitungan kalori dengan metode yang tepat guna mengetahui keidealaan atau keseimbangan gizi yang dibutuhkan atlet panjat tebing selama masa TC (Technical Center) berlangsung, Tujuan dari penelitian ini untuk mengetahui optimasi zat gizi yang ideal bagi atlet panjat tebing kota blitar. Studi khasus ini menggunakan metode PROFIFEA (Population Resizing on Fitness Improvement Fuzzy Evolutionary Algorithm) untuk menentukan kebutuhan zat gizi atle panjat tebing, didapatkan hasil optimasi zat gizi yaitu dengan pengeluaran energi pada saat latihan per hari 2731.31 kkal, dan optimasi zat gizi yang diperoleh membutuhkan 864, 81 kkal karbohidrat, 407,78 kkal protein dan 174,07 kkal lemak perharinya untuk menghasilkan keseimbangan tubuh yang ideal dan didapatkan hasil pengujian menggunakan AFER (Average Forecasting Error Rate) yang terdapat nilai error sebesar 0.02% yang artinya pengujian dalam perhitungan tersebut bisa dikatakan optimal. Diharapkan penelitian ini dapat membantu pembina atlet panjat tebing kota blitar untuk mengetahui berapa kalori atau kecukupan gizi yang dibutuhkan untuk keidealan tubuh para atlet.
SISTEM PENDUKUNG KEPUTUSAN PENENTUAN DOSEN PEMBIMBING DENGAN METODE AHP (ANALITYCAL HIERARCHY PROCESS)
Authors: Petro Ama Kii David , Elefri Neno Friden , Ema Ose Sanga Felysistas 
Published: February 2024

Tugas akhir merupakan bagian dari matakuliah akhir yang harus diselesaikan oleh mahasiswa dalam melakukan bimbingan dengan dosen pembimbing 1 dan dosen pembimbing 2, masiswa sebelum melakukan bimbingan tahap pertama yang harus dilakukan adalah menentukan judul penelitian tugas akhir dan judul disetujui oleh ketua prodi teknik informatika komputer STIMIKOM Stella Maris Sumba dan sesudah judul tugas proposal tugas akhir disetujui ketua prodi teknik informatika menentukan dosen pembimbing 1 (Satu) dan 2(Dua) untuk memulai mahasiswa tugas akhir melaksanakan bimbingan. Penentuan dosen pembimbing tugas akhit pada Prodi teknik informatika belum digunakan sistem komputerisasi untuk menunjnag dalam penyimpanan data dalam database sehingga membutuhkan waktu yang lama dan sering juga terjadi pendobelan judul tugas akhir yang sama, oleh karena itu dalam penelitian ini mengamati bahwa sistem yang digunakan tidak efisien.dalam menentukan dosen yang tidak sesuai dengan konsentrasi dan pengalaman membimbing, pada penelitian ini peneliti menganalisa data dengan metode AHP (Analitycal Hierarchy Process) untuk mementukan dosen pembimbing berdasarkan kriteria dan dilakukan perangkingan untuk mengurutkan dari dosen yang layak membimbing dari urutan pertama ke urutan berikutnya.dan diterapkan ke pembangunan sistem pendukung keputusan dengan metode AHP (Analitycal Hierarchy Process).