bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial function using two dimension speckle-tracking echocardiography in children with celiac disease
Authors: El Amrousy Doaa , Elshehaby Walid , Elsharaby Radwa , Badr Shaimaa , Hamza Mohamed , Elbarky Amany 
Published: December 2023

AbstractThe prevalence of cardiac complications linked to celiac disease (CD) is on expanding. This study aimed to evaluate the cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE) to detect early myocardial dysfunction, if any. This cross-sectional study included 40 children with CD as the patient group and 40 healthy age- and sex-matched children served as the control group. High sensitive troponin T (Hs-troponin T), anti-tissue transglutaminase immunoglobulin A (tTG-IgA), hemoglobin, ferritin, albumin, and vitamin D levels were measured in all participants. Conventional, tissue Doppler imaging (TDI), and 2D-STE were performed for all included children. Conventional echocardiographic parameters showed no significant difference between the two groups. Left ventricular global longitudinal strain (LV GLS) obtained by 2D-STE was substantially lower in children with CD than the control group; however, myocardial performance index (MPI) obtained by TDI was significantly higher in children with CD. Hs-troponin T levels were comparable in both groups. LV GLS was positively correlated with hemoglobin, ferritin, and albumin level, but it was inversely correlated with the duration of the disease and anti tTG-IgA. Conclusion: 2D-STE can detect subclinical early cardiac dysfunction in children with CD and this cardiac injury correlated to the duration and severity of the disease and some nutritional deficiency in these children.What is Known:• The prevalence of cardiac complications linked to celiac disease (CD) is on expanding.• Only one study evaluated cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE).What is New:• Our study found that 2D-STE can detect early subclinical cardiac dysfunction in children with CD. Cardiac injury in theses children correlated to the duration and severity of the disease, hemglobin, ferritin, and albumin levels.
Advanced optimization models for the location of charging stations in e-mobility
Authors: Staněk Rostislav , Greistorfer Peter , Kastner Anna Elisabeth 
Published: December 2023

AbstractFor a reduction in environmental pollution and dependency on petroleum, electric vehicles (EV) present an advantageous alternative to traditionally fossil-fuel powered automobiles. Rapid growth in the number of EVs requires an urgent need to develop an adequate charging station infrastructure to stimulate and facilitate their usage. Due to restricted investments in the development of a sufficient infrastructure, locations have to be chosen deliberately. In this paper, two extensions considering different objectives and further constraints to the deterministic flow refuelling location problem (DFRLP), described by Vries and Duijzer (Omega 69:102–114, 2017), are introduced. First, our research shows that location-dependent construction costs significantly influence the charging infrastructure obtained. Tests for different cost scenarios are carried out and policy implications are discussed. The original DFRLP assumes an unlimited capacity, meaning it is always possible to refuel all EVs at all charging stations, where they stop. Hence, for a more realistic modelling, we assume a limited capacity of charging stations in our second extension. Finally, both extensions are evaluated using benchmark instances based on test instances from the literature.
Product Sustainability and Consumer Environmental Awareness in Differentiated Markets
Authors: Hamoudi Hamid , Avilés-Palacios Carmen 
Published: December 2023

AbstractSustainable management of natural stock resources can be promoted through state intervention. This study investigates optimal regulatory strategies to mitigate the negative environmental effects of human activities within a duopolistic, differentiated linear market à la Hotelling framework. The analysis is conducted from both a business and a social perspective, aiming to elucidate the role of regulatory interventions, awareness campaigns, and sustainable production characteristics in shaping firm behavior and market outcomes. Under the business perspective, a game-theoretical approach is employed, involving the regulator and two competing firms. The equilibrium in prices and production characteristics is derived, revealing how firms respond to sustainable characteristics and awareness campaigns. In the social perspective, where the regulator has complete control, optimal strategies are determined to maximize social welfare, resulting in reduced differentiation and enhanced sustainability. This study identifies the optimal level of awareness campaign and sustainable characteristic proposed by the regulator. The findings highlight the significance of coordinated regulatory policies and awareness campaigns to induce firms toward more sustainable practices, ultimately contributing to a more ecologically balanced market. The study offers insights for policymakers and practitioners seeking effective strategies to address environmental concerns in differentiated markets, thereby promoting sustainable economic growth and reducing ecological impacts.
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
Authors: Ungvari Zoltan , Tabák Adam G. , Adany Roza , Purebl György , Kaposvári Csilla , Fazekas-Pongor Vince , Csípő Tamás , Szarvas Zsófia , Horváth Krisztián , Mukli Peter , Balog Piroska , Bodizs Robert , Ujma Peter , Stauder Adrienne , Belsky Daniel W. , Kovács Illés , Yabluchanskiy Andriy , Maier Andrea B. , Moizs Mariann , Östlin Piroska , Yon Yongjie , Varga Péter , Vokó Zoltán , Papp Magor , Takács István , Vásárhelyi Barna , Torzsa Péter , Ferdinandy Péter , Csiszar Anna , Benyó Zoltán , Szabó Attila J. , Dörnyei Gabriella , Kivimäki Mika , Kellermayer Miklos , Merkely Bela 
Published: December 2023

AbstractThe Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
Influence of standard culture conditions and effect of oleoresin from the microalga Haematococcus pluvialis on splenic cells from healthy Balb/c mice — a pilot study
Authors: Jurčacková Zuzana , Ciglanová Denisa , Mudroňová Dagmar , Bárcenas-Pérez Daniela , Cheel José , Hrčková Gabriela 
Published: December 2023

AbstractIn this work, we used splenocytes from healthy mice to study the effects of the two most commonly used cell culture media (A, B) with different compositions of redox reagents. The incubation of cells for 24 h resulted in a significant decrease in viability and metabolic activity of splenocytes, and the negative effects of incubation in medium B were more pronounced. In standard conditions, oxidative stress in cells was manifested by reduced mitochondrial potential, and this effect correlated with the transition of 58.3% of cells to the early stage of apoptosis under reducing conditions of medium A and up to 66.1% of cells under super-reducing conditions in medium B, suggesting altered cell physiology. High levels of ROS/RNS activated transcription factor Nrf2, superoxide dismutase 1, and catalase. The higher mRNA levels of these genes were under the conditions of medium B, whose super-reducing environment in combination with the environment of conventional incubators proved to be less suitable for the cells compared to medium A. Treatment of the cells with a lower concentration (10 µg/ml) of oleoresin obtained from the microalga H. pluvialis partially eliminated the negative effects of cultivation. Higher concentration of oleoresin (40 µg/ml) was slightly cytotoxic, due to the significant antioxidant effect of astaxanthin, the main bioactive component of the extract, which eliminated most of the ROS/RNS acting as signalling molecules. This study shows that the standard culture conditions do not reflect the physiological in vivo cell conditions; therefore, they are not generally suitable for incubation of all cell types.
Evaluation of an application for the self-assessment of lifestyle behaviour in cardiac patients
Authors: Goevaerts Wilhelmina F. , Tenbült—van Limpt Nicole C. C. W. , Lu Yuan , Kop Willem J. , Kemps Hareld M. C. , Brouwers Rutger W. M. 
Published: December 2023

Abstract
Background
Currently, no uniform, well-validated and comprehensive lifestyle behaviour self-assessment instrument exists for patients with cardiovascular disease.

Purpose
To evaluate the usability of a novel mobile application (LifeStyleScore) based on validated instruments for the assessment of cardiovascular risk behaviours. Secondly, the application’s acceptance by healthcare professionals (HCPs) and its association with improved patient activation and lifestyle behaviour was evaluated.

Methods
In this single-centre, non-randomised observational pilot study, patients with coronary artery disease or atrial fibrillation entering cardiac rehabilitation (CR) completed the LifeStyleScore application, the Patient Activation Measure (PAM-13®), and the System Usability Scale (SUS) during the CR intake and after CR completion. A focus group interview was performed with the HCPs involved.

Results
We analysed 20 participants, 3 of whom were women, with a mean age of 61.9 ± 6.7 years. The LifeStyleScore application was rated with a SUS score above average (> 68) before (69.6 ± 13.4) and after CR (68.6 ± 15.1). All HCPs (n = 8) found the application usable. Patient activation did not increase significantly after CR compared with baseline (62.0 ± 8.6 versus 59.2 ± 9.5, respectively, p = 0.28) and only physical activity levels improved significantly (2.4 ± 0.7 (standardised score) at baseline, 2.8 ± 0.4 after CR, p = 0.04).

Conclusion
The LifeStyleScore application was found to be usable for patients receiving CR. Its use did not result in increased patient activation, and of the lifestyle behaviours only physical activity levels improved. Further research is needed to evaluate how such applications can be optimally incorporated in CR programmes.
The Impact of Foreign Trade in the Graduation Process of Asian Least-Developed Countries (LDCs)
Authors: Navarro-Pabsdorf Margarita , Cuenca-Garcia Eduardo , Quiros-Gonzalez Estela 
Published: December 2023

AbstractThe importance of development studies comes from the need to assess and solve economic problems. Graduation from LDC status represents an important milestone in their development path. This research tries to deepen on the relationship between the fulfillment of the “graduation criteria” established by the United Nations and the evolution of the foreign trade indices of a group of Asian LDCs about to graduate (Bangladesh, Bhutan, Laos, Timor-Leste, Nepal, and Myanmar), checking how trade, one of its engines for economic development, has involved during the last years and, specifically, on their way to graduation. First, the characteristics of the LDCs and the criteria to exclude them from the list are analyzed. Second, a set of indices are presented to find out the trade flows throughout the period observed. Finally, conclusions and future lines of research are proposed. The results show that all the countries studied have succeeded in expanding their share in world trade. The high participation of Bangladesh is justified by the size of its economy and its weight within the textile trade. Regarding diversification, all of countries present a highly concentrated pattern of exports and their exchanges are carried out with few countries. This lack of trade diversification places them in a vulnerable position. The relative trade balance index indicates that all of them are competitive with their trading partners in the products analyzed and the six have comparative advantage. To conclude, the analysis confirms that the trade structure of the LDCs considered has improved, but with differences due to their characteristics.
Cox rings of blow-ups of multiprojective spaces
Authors: Bolognesi Michele , Massarenti Alex , Poma Elena 
Published: December 2023

AbstractLet $$X^{1,n}_r$$

X
r

1
,
n

be the blow-up of $$\mathbb {P}^1\times \mathbb {P}^n$$

P

1

×

P

n

in r general points. We describe the Mori cone of $$X^{1,n}_r$$

X
r

1
,
n

for $$r\le n+2$$

r
≤
n
+
2

and for $$r = n+3$$

r
=
n
+
3

when $$n\le 4$$

n
≤
4

. Furthermore, we prove that $$X^{1,n}_{n+1}$$

X

n
+
1

1
,
n

is log Fano and give an explicit presentation for its Cox ring.
RSV vaccination strategies for high-risk patients 2023: a collaborative position paper by leading German medical societies and organizations
Authors: Addo Marylyn , Cornely Oliver , Denkinger Michael , Ertl Georg , Herold Susanne , Pletz Mathias , Rohde Gernot , Welte Tobias , Windisch Wolfram , Witzenrath Martin 
Published: December 2023

AbstractRespiratory syncytial virus (RSV) inflicts severe illness and courses of infections not only in neonates, infants, and young children, but also causes significant morbidity and mortality in older adults and in people with immunosuppression, hemato-oncologic disease, chronic lung disease, or cardiovascular disease. In June and August 2023, effective vaccines against RSV were approved for the first time by the European Medicines Agency (EMA) for the EU. The respective pivotal studies showed a very high efficacy of the vaccine in preventing severe RSV-associated respiratory infections. At this point, use of the respective vaccines is restricted to persons aged 60 years or older, according to the registration studies. We therefore recommend use of the vaccination in persons aged 60 years or older. In addition, we recommend use of the vaccination in adults of any age with severe pulmonary or cardiovascular pre-existing conditions, as well as in adults with significant immune compromise, after individual consultation with the treating physician. Cost coverage can be applied for individually with the responsible health insurance company.
A note on the inhomogeneous fractional nonlinear Schrödinger equation
Authors: Saanouni Tarek , Shi Qihong 
Published: December 2023

AbstractThis paper investigates some well-posedness issues of the fractional inhomogeneous Schrödinger equation $$\begin{aligned} i\dot{u}-(-\Delta )^\gamma u=\pm |x|^\rho |u|^{p-1}u, \end{aligned}$$

i

u
˙

-

(
-
Δ
)

γ

u
=
±

|
x
|

ρ

|
u
|

p
-
1

u
,

where $$0<\gamma <1$$

0
<
γ
<
1

and $$\rho <0$$

ρ
<
0

. Here, one considers the inter-critical regime $$0<s_c:=\frac{N}{2}-\frac{2\gamma +\rho }{p-1}<\gamma $$

0
<

s
c

:
=

N
2

-

2
γ
+
ρ

p
-
1

<
γ

, where $$s_c$$

s
c

is the energy critical exponent, which is the only one real number satisfying $$\Vert \kappa ^\frac{2\gamma +\rho }{p-1}u_0(\kappa \cdot )\Vert _{\dot{H}^{s_c}}=\Vert u_0\Vert _{\dot{H}^{s_c}}$$

‖

κ

2
γ
+
ρ

p
-
1

u
0

(
κ
·
)

‖

H
˙

s
c

=

‖

u
0

‖

H
˙

s
c

. In order to avoid a loss of regularity in Strichartz estimates, one assumes that the datum is spherically symmetric. First, using a sharp Gagliardo–Nirenberg-type estimate, one develops a local theory in the space $$\dot{H}^\gamma \cap \dot{H}^{s_c}$$

H
˙

γ

∩

H
˙

s
c

. Then, one investigates the $$L^{\frac{N(p-1)}{\rho +2\gamma }}$$

L

N
(
p
-
1
)

ρ
+
2
γ

concentration of finite-time blow-up solutions bounded in $$\dot{H}^{s_c}$$

H
˙

s
c

. Finally, one proves the existence of non-global solutions with negative energy. Since one considers the homogeneous Sobolev space $$\dot{H}^{s_c}$$

H
˙

s
c

, the main difficulty here is to avoid the mass conservation law.
Robustness evaluation of the damped outrigger structure
Authors: Kavyashree B. G. , Patil Shantharam , Rao Vidya S. 
Published: December 2023

AbstractRobustness is defined as the insensitivity of the structure to uncertainties like earthquakes, fire, cyclones, explosions, tsunamis, etc. Robustness analysis of Kalman observer with robust controller for damped outrigger structure is studied to analyze its design performance in the presence of various effects like an earthquake. This is a novel innovative study undertaken in evaluating the robustness of the proposed controller to signify its performance in the field of structural control. The damped outrigger structure is modeled using the finite element approach by finding mode shapes, fundamental natural frequency, and period. The Kalman observer is modeled according to the requirement of the structure with the Riccati equation. The robust proportional–integral–derivative controller is designed according to the input disturbance with Ziegler–Nichols ultimate gain approach. The issue of deterioration in the system performance due to saturation was observed during the analytical investigation of the robust proportional–integral–derivative controller with Kalman observer, which has been addressed by the anti-windup approach. The robustness index of the structure is calculated using sensitivity and complementary sensitivity. The maximum amplitude ratio of the sensitivity for viscous damper-controlled structure is 1.4723 and the value decreases for the other controllers, with a minimum value of 1.0 for the proposed anti-windup robust proportional–integral–derivative controller with Kalman observer. Respectively, the percentage overshoot for the uncontrolled case is 23.4% that values decreasing for other controlled cases, with a minimum of 7.8% for proposed anti-windup robust proportional–integral–derivative controller with Kalman observer. This robustness index and performance indices discriminate the significant robust performance of the proposed robust proportional–integral–derivative controller with Kalman observer-based damped outrigger structure in comparison with other controlled and uncontrolled cases.
Short-Answer Grading for German: Addressing the Challenges
Authors: Padó Ulrike , Eryilmaz Yunus , Kirschner Larissa 
Published: December 2023

AbstractShort-Answer Grading (SAG) is a time-consuming task for teachers that automated SAG models have long promised to make easier. However, there are three challenges for their broad-scale adoption: A technical challenge regarding the need for high-quality models, which is exacerbated for languages with fewer resources than English; a usability challenge in adapting high-quality research prototypes to the needs of non-expert users, and a trust challenge in communicating the abilities and limitations of the tools. We propose to meet the technical challenge for German with a robust Transformer-based SAG model. We address the usability challenge with an easy-to-use graphical user interface for the SAG model, and the trust challenge with a workflow that allows teachers to evaluate the model on their own data, to choose on the basis of this evaluation which model predictions to trust, and in consequence to stay in control of grading their students while saving grading effort.
Formalizing complexity in the life sciences: systems, emergence, and metafluxes
Authors: Wegner Lars H. 
Published: December 2023

AbstractCurrent plant sciences (as the life sciences in general) tend to follow an empirical rationale focussing on the molecular scale (genes, proteins), which is supposed to causally dominate processes at higher levels of organization (cellular, organismic). This rather simplistic view on the complexity of living systems calls for a more adequate and elaborate theoretical approach, to which I want to contribute three main cornerstones here. Systems theory is the first one, mostly referring to Mario Bunge’s CESM (Composition, Environment, Structure, Mechanism) approach and its biological application. More than half of this article is dedicated to the philosophical concept of emergence, denoting the fact that systems have specific properties not shared or provided by their parts. Different viewpoints on emergence and definitions are contrasted and their potential suitability for the life sciences is discussed. An interesting historical case study is the genesis of the ‘ecosystem’ concept in plant ecology. Subsequently two widely accepted subtypes, ‘weak’ and ‘strong’ emergence are introduced and their quantitative formalization is briefly outlined referring to recent work on this issue. Finally, the metaflux concept is presented for the first time. Living systems are characterized by a network of coupled fluxes of matter, free energy, and entropy, adequately formalized by the thermodynamics of irreversible processes. Dynamical phenomena in organisms emerging from these flux networks which are, in contrast to process philosophy/metaphysics, defined on a scientific (physicochemical) basis will be called ‘metafluxes’. Metafluxes and weak and strong emergence are non-exclusive concepts to be employed in a dialectic scientific process.
Human-Inspired Non-prehensile Manipulation Strategies: Design, Implementation, and Evaluation
Authors: Bhat Pooja , Nieuwenhuisen Matthias , Schulz Dirk 
Published: December 2023

AbstractGrasping of objects is not always feasible for robot manipulators, e.g., due to their geometric properties. Non-prehensile manipulation strategies can enable manipulators to successfully move these objects around. We analyze human-inspired gripper configurations for pushing small or heavy objects and propose closed-loop pushing strategies based on force-torque measurements as well as open-loop strategies to push small objects. In a thorough evaluation on a KUKA LWR4+ manipulator arm and in simulation, we discuss the effects of the different designs and strategies.