bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Developments in Artificial Intelligence on Copyright and other Intellectual Property Laws
Authors: Israhadi Evita Isretno 
Published: November 2023

Objective: The objective of this study is to investigate the impact of AI breakthroughs on copyright and challenges faced by intellectual property legal protection systems. Specifically, the study aims to analyze the implications of AI-generated works in the context of copyright law in Indonesia.

Method: The research employs a normative legal approach, utilizing secondary data sources including books, legal journals, research findings, and statutory regulatory documents. The study focuses on relevant legal frameworks, such as Law No. 28 of 2014 governing copyright in Indonesia. The analysis is based on existing literature and legal documents to understand the current state of AI-generated works and their eligibility for copyright protection.

Result: The research findings reveal that according to Law Number 28 of 2014 in Indonesia, AI-generated works do not meet the originality standards required for copyright protection. However, users of AI-generated works are still bound by the terms and conditions set by the AI platform, which can limit their rights to the work. The impact of AI developments on copyright law includes challenges related to determining creators and copyright holders, redefining the concept of originality, increased instances of copyright infringement, issues concerning moral and personality rights, and collaborations involving both humans and AI. Additionally, challenges related to database protection and patent protection in the context of AI are also highlighted.

Conclusion: In conclusion, the advancement of AI technology introduces complexities in intellectual property law. The existing legal frameworks, such as copyright laws, need further adaptation and clarification to effectively regulate AI-generated works in the digital era. Addressing issues related to originality, creatorship, and collaborative works involving AI requires careful consideration and legal adjustments. Additionally, challenges related to database and patent protection in the realm of AI need to be addressed to ensure comprehensive intellectual property protection in the face of evolving technologies. Legal adaptation and clarification are crucial to navigating the intricate intersection of AI and intellectual property law.
A-polynomial for some family of caveman graphs
Authors: Ramane Harishchandra , Patil Daneshwari 
Published: November 2023

The caveman graph is a graph formed by modifying a set of isolated k-cliques (or caves) by removing one edge from each clique and using it to connect to a neighboring clique along a central cycle such that all n cliques form a single unbroken loop. Caveman graph containing n-copies of k-cliques is denoted as, (n,k)-caveman graph. For a graph G, the A-matrix is defined as, A(G)=[aij] in which aij=1 if vertices vi and vj are adjacent; and 0 otherwise. The polynomial associated with A-matrix is the A-polynomial. In this work, we study A-polynomial for some family of caveman graphs.
Predictive Effects of Platelet Indices in Cirrhotic Patients with or without Portal Vein Thrombosis
Authors: Araz Filiz , Soydaş Barış 
Published: November 2023

Objective: Portal vein thrombosis (PVT) is a common finding in liver cirrhosis. Besides low portal blood flow, thrombophilia, bacterial translocation and endotoxemia, platelets which are considered as important source of prothrombotic agents may play a role in thrombotic events in cirrhosis. Large platelets have been reported to have numerous granules that result in greater thrombotic and proinflammatory activity. We aimed to define the role of platelet indices in PVT among cirrhotic patients.
Method: Cirrhotic patients admitted to Gastroenterology Clinic and having a dynamic radiological examination were assessed retrospectively. Demographic and laboratory findings were recorded including platelet distribution width (PDW) and mean platelet volume (MPV). Severity of cirrhosis was assessed with MELD (Model for End Stage Liver Disease) and Child-Pugh-Turcotte (CPT) scores
Results: Study included 255 patients. Mean age was 60.6±10.2 years. 41.6% of patients were female. 50 (19.6%) patients had PVT. Patients with PVT did not differed from those without PVT in age, gender and presence of diabetes mellitus. Median platelet count was lower in patients with PVT (100 (22-370) vs 79,5 (22-573), p: 0,033). Mean MPV and PDW levels were similar between PVT and non-PVT groups (p >0.05). Although median MELD scores did not differ between groups, median CPT scores were significantly higher in PVT compared to non-PVT group (p:0,027).
Conclusion: Cirrhotic patients with PVT had more prominent thrombocytopenia, but similar MPV and PDW levels compared to those without PVT.
Effect of probiotic on shrimp immune system and protection against Vibrio parahaemolyticus infection
Authors:   , Chomwong Sudarat 
Published: November 2023

Lactic acid bacteria (LAB) are proposed as potential probiotic candidates in aquaculture and also known to be present in the gut of healthy aquatic animals. To isolate LAB from the gut of the white shrimp Litopenaeus vannamei, intestines were collected and the isolation of 89 LAB isolates was carried out using the MRS selective agar plate. The 16S ribosomal DNA (16S rDNA) sequence analysis reveals that most of the bacterial isolates identified from shrimp guts are the strain of LAB. Two candidate probiotics, Lactobacillus plantarum and Lactococcus lactis were selected for in vitro antimicrobial activity assay. The results indicated that cell-free supernatant of two probiotics contained antimicrobial substances actively against Vibrio parahaemolyticus causing Early mortality syndrome (EMS)/Acute Hepatopancreatic Necrosis Disease (AHPND) (VPAHPND). Administrations of two probiotic-supplemented feed enhanced the survival rate of shrimp upon infection with VPAHPND. In order to investigate the effect of the two probiotic strains on the shrimp innate immune system, immune activity and mRNA levels were monitored. The results indicated that oral administration of probiotic increased the level of prophenoloxidase and SOD activities. Moreover, expression levels of LvproPO1 and LvproPO2, but not LvPacifastin-like in midgut are significantly up-regulated after probiotic L. plantarum and L. lactis feeding. To examine the involvement of proPO-related genes in VPAHPND infection, temporal gene expressions were analyzed and showed that the LvproPO1 transcript level was downregulated at 24-48h and then returned to non-stimulated levels at 72 h. These finding suggests that two candidate probiotic LAB could enhance the immune system of shrimp L. vannamei and increase the resistance to VPAHPND infection.
Free radical scavenging and antiproliferative activities of peptide from monkey’s head mushroom (Hericium erinaceus)
Authors:   , Sangtitanu Taniya 
Published: November 2023

Free radicals have been identified as a major trigger of various syndromes in living systems. Oxidative stress occurs when free radicals are excessive and antioxidants are insufficient, resulting in the necessary consumption of additional antioxidants. Peptide derived from monkey’s head mushroom seeds was hydrolysed using various concentrations (1, 2.5, and 5%) of proteases (Alcalase, Favourzyme, and Neutrase), and the 1% Alcalase hydrolysate exhibited the highest radical scavenging activities (DPPH, ABTS, and NO assay) compared to other hydrolysates. After ultrafiltration, Mw < 0.65 kDa showed the strongest activity. Then, Mw < 0.65 kDa was purified using gel filtration chromatography and separated into two fractions (F1, and F2), of which fraction F1 exhibited the highest activity and this was further purified by reversed phase high performance liquid chromatography. Four fractions (F11, F12, F13, and F14) from RP-HPLC were isolated. Thus, four antioxidant peptides were identified by quadrupole time-of-flight (Q-TOF) mass spectrometer. The cytotoxicity activity of the fraction F1 was determined by MTT assay in five cell lines. The results showed that F1 exhibited greater inhibition against the proliferation of Chago-K1 cell lines. Moreover, the fraction F1 has the protective activity of the hydroxy radical-induced DNA damage as shown in pBR322, pKS and pUC19. The apoptosis of F1 was measured by an FITC Annexin V Apoptosis Detection Kit with PI using flow cytometry and caspase 3, 8 and 9 activities were determined in Chago-K1 cells for 24, 48, and 72 hours. The findings indicate that monkey’s head mushroom is a source of antioxidant peptides. Consequently, this suggests the importance of monkey’s head mushroom as a source of antioxidant peptides.
Mindestlöhne, Beschäftigung und die ‚Harmonie der Täuschungen‘
Authors: Heise Arne 
Published: November 2023

In der Wirtschaftsgeschichte hat es immer wieder Phänomene – Anomalien – gegeben, die als unvereinbar mit der herrschenden Ökonomik erschienen. Wenn dies dennoch bis heute zu keinem Paradigmenwechsel in der Dogmengeschichte der Wirtschaftswissenschaften führte, so zeigt sich hierin die besondere Resilienz des herrschenden Paradigmas.
In diesem Artikel geht es darum, mit Hilfe der Wissenschaftstheorie Ludwik Flecks die Hintergründe, aber auch Gefahren dieser Resilienz aufzuzeigen und – unter besonderer Betrachtung der Forschungen zur Arbeitsmarktökonomik des Mindestlohnes – zu untersuchen, ob ein zwingend benötigter ‚stilgemäßer Denkzwang‘ nicht unter Umständen zu einer ‚Harmonie der Täuschungen‘ entarten kann und deshalb den empirische Anomalien größere Aufmerksamkeiten eingeräumt werden müsste?
APLIKASI PENGENALAN HEWAN BERBASIS AUGMENTED REALITY MENGGUNAKAN METODE MARKER BASED TRACKING BERBASIS ANDROID
Authors: Aditya Suhendra Agung , Mahirssa Rafif , Samsul Rafli  , Yoga Sahira  
Published: November 2023

Pembelajaran pengenalan berpengaruh dalam tumbuh kembang anak, anak – anak mulai belajar melakukan identifikasi, mengasah pengetahuan dan daya ingat, salah satunya adalah dengan pengenalan hewan, umumnya pengenalan hewan dilakukan dengan menggunakan media gambar atau video, tetapi banyak anak - anak terutama usia dini yang kurang tertarik dalam proses pengenalan hewan dengan menggunakan media gambar karena tidak bisa melihat bentuk langsung dari hewan, untuk melihat bentuk asli dari hewan tersebut biasanya harus mendatangi kebun binatang. Augmented Reality merupakan teknologi yang mampu menggabungkan objek 2D atau 3D dan merekayasa kedalam dunia nyata, dengan menggunakan teknologi augmented reality yang di implementasikan kedalam aplikasi pengenalan hewan berbasis android diharapkan dapat meningkatkan daya tarik anak – anak sebagai media pembelajaran pengenalan hewan, tujuan dari penelitian ini adalah membangun aplikasi pengenalan hewan dengan menggunakan metode MDLC (Multimedia Developmnt Life Cycle) untuk pengembangan aplikasi dan menggunakan metode marker based tracking untuk dapat memunculkan objek 3D diatas marker atau penanda 2D, aplikasi dibangun secara menarik dan informatif, hasil dari penelitian aplikasi tidak hanya menampilkan objek 3D hewan, tetapi aplikasi juga mampu memberikan informasi mengenai hewan yang ditampilkan dan aplikasi juga memiliki fitur seperti mengeluarkan suara hewan, zoom in, zoom out, rotasi untuk melihat bentuk 3D hewan secara detail, dengan demikian diharapkan anak – anak menjadi lebih tertarik dalam proses pembelajaran pengenalan hewan.
Impacto da pandemia do COVID-19 na saúde mental dos estudantes de medicina (DASS-21)
Authors: Castro Victória de Souza Damasceno , Pereira Laura Nagem Júlio , Lima Daniel José Matos de Medeiros 
Published: November 2023

Introdução: A pandemia do COVID-19, declarada pela Organização Mundial da Saúde em março de 2020, trouxe consigo uma série de desafios sem precedentes para a sociedade global. Além das implicações diretas na saúde física, as consequências psicológicas e emocionais da pandemia têm sido motivo de crescente preocupação. Estudantes de medicina, em particular, encontram-se em uma posição única, estando na linha de frente do combate ao vírus e, ao mesmo tempo, enfrentando as pressões acadêmicas e clínicas. Este cenário pode ter ampliado os riscos de problemas de saúde mental neste grupo. Objetivos: Avaliar a prevalência de sintomas de ansiedade, depressão e estresse entre os estudantes de medicina após a pandemia do COVID-19. Métodos: Foi realizado a aplicação do questionário DASS-21 (Depression, Anxiety and Stress Scale) para identificar o risco de depressão, ansiedade e estresse em estudantes do 5º ao 9º período do Curso de Medicina da Faculdade de Medicina de Campos. Autorizado pelo CEP 40145420.0.0000.5244. Resultados: Entre 143 respostas de estudantes da faculdade de medicina de campos, 62,2% eram mulheres e 37,8% eram homens. A média de idade foi de 21,76±3,1 anos. Quanto ao questionário DASS-21, foi observado que as três variáveis avaliadas, estresse, ansiedade e depressão, mostraram: Ansiedade - 44% normal e 56% apresentam algum grau de ansiedade. Com relação a depressão, 50,35% normal e 49,65% apresentem algum grau de depressão. Já o estresse, 31,47% normal e 68,55% apresentam algum grau de estresse. Conclusão: A pandemia impactou na saúde mental dos estudantes de medicina, ficando evidente que a maioria apresenta algum grau de ansiedade, depressão e estresse. Esses dados ressaltam a necessidade urgente de intervenções de apoio psicológico para este grupo.
PENGARUH PEER EDUCATION TERHADAP PENGETAHUAN DAN SIKAP MENGENAI PREMENSTRUAL SYNDROM PADA SISWI SMP
Authors: Supliyani Elin , Yanti Risna Dewi 
Published: November 2023

Salah satu gangguan yang berhubungan dengan haid adalah Pre Menstrual Syndrome. Berbagai sumber informasi mengenai Premenstrual Syndrom dapat diperoleh, baik dari keluarga maupun dari lingkungan luar, dan akan lebih baik jika didapatkan dari teman atau kelompok sebaya dimana mereka akan lebih terbuka dan lebih mendalam dalam melakukan sharing terutama tentang hal-hal yang positif. Oleh sebab itu diperlukan usaha untuk memberikan pendampingan kepada remaja untuk memberikan pengetahuan dan membentuk sikap yang positif tentang premenstrual syndrom. Upaya yang dapat dilakukan adalah membentuk kelompok sebaya (peer grup). Tujuan penelitian ini adalah mengetahui pengaruh Peer Education terhadap pengetahuan dan sikap mengenai Premenstrual Syndrom pada siswi SMP di Kota Bogor dengan desain pre-experimental, yaitu one group pre-test post-test, Pengambilan sampling menggunakan teknik Cluster Sampling di SMP 6 kelas VII sejumlah 42 orang. Analisis bivariat dilakukan uji Wilkoxon untuk mengetahui pengaruh Peer Education terhadap peningkatan pengetahuan mengenai Premenstrual Syndrom, sedangkan t-dependent untuk mengetahui pengaruh Peer Education terhadap sikap mengenai Premenstrual Syndrom. Hasil diperoleh adanya peningkatan pengetahuan yang signifikan dengan nilai p 0.000 (p<0.005). Begitu pula terdapat peningkatan sikap yang signifikan dengan rerata 51.69 menjadi 56.04, nilai p 0.000 (p<0.005). Peer Education berpengaruh terhadap pengetahuan dan sikap mengenai Premenstrual Syndrom pada siswi SMP, oleh sebab itu d isarankan agardibentuk peer group education di sekolah-sekolah dan senantiasa melakukan pendidikan kesehatan tentang kesehatan reproduksi remaja khususnya tentang Premenstrual Syndrom

Kata kunci : Peer Education, pengetahuan, sikap
EFEKTIVITAS PEMBERIAN SNACK BAR TAPE KETAN HITAM TERHADAP POLA DEFEKASI IBU NIFAS
Authors: Yanti Risna Dewi 
Published: November 2023

Sistem pencernaan pada masa nifas mengalami perubahan fisiologis yang berdampak pada kesulitan defekasi. Hal ini disebabkan tonus otot usus menurun selama proses persalinan dan awal masa pascapartum, diare sebelum persalinan, kurang makan, dehidrasi, hemoroid ataupun laserasi jalan lahir . Pemberian makanan yang mengandung serat tinggi untuk memperlancar defekasi sehingga mencegah konstipasi pada ibu nifas dianggap cukup efektif. Serat makanan memiliki kemampuan mengikat air di dalam kolon membuat volume feses menjadi lebih besar dan akan merangsang saraf pada rektum sehingga menimbulkan keinginan untuk defekasi. Dengan demikian feses lebih mudah dieliminir. Pengaruh nyata yang telah dibuktikan yaitu bertambahnya volume feses, melunakkan konsistensi feses dan memperpendek waktu transit di usus. Salah satu pangan sumber serat, yaitu tape ketan hitam 5,9 gram/100 gram. Tujuan penelitian untuk mengetahui Efektifitas Pemberian Snack Bar Tape Ketan Hitam Terhadap Pola Defekasi Ibu Nifas. Penelitian ini menggunakan desain penelitian quasi eksperimen(two grouppost design) untuk mengetahui pengaruh pemberian snack bar tape ketan hitam terhadap poladefekasi ibu nifas. Tempat penelitian ini di wilayah kota bogor, dilaksanakan mulai bulan Februari-oktober 2019 dengan sampel ibu nifas sejumlah 30 orang untuk tiap kelompok dengan total sampel 60 orang. Analisis bivariat dilakukan uji Mann Whitney. Hasil analisis data terdapat perbedaan yang signifikan pemberian snack Bar Tape Ketan Hitam terhadap pola defekasi pada ibu nifas dengan nilai P=0,00. Kesimpulan dari hasil penelitian ini adalah bahwa pemberian snack bar tape ketan hitam efektif terhadap pola defekasi.
Analysis of Physical Workload of Midwife with The Application of Patient Safety During The Covid-19 Pandemic at Regency Hospitals Bekasi, 2021
Authors: Mariyani Mariyani 
Published: November 2023

Background: Working in challenging conditions such as during the Covid-19 pandemic can have an impact on the ability of health workers to provide safe and effective care.Research Objectives: To determine the relationship between the physical workload of midwife and the application of patient safety during the Covid-19 pandemic at the Bekasi District Hospital in 2021.Research Methods: This study uses a quantitative approach with a cross sectional research design. The total population in this study were 94 respondents and the sampling technique was simple random sampling with a sample of 55 respondents. The instrument in this study is a questionnaire. The analysis used is univariate and bivariate analysis.Research results: From 55 respondents, it was found that the total physical workload of midwife was 33 people and midwife who implemented good patient safety were 11 people (33.3%), while the physical workload of midwife who were moderate was 19 people and midwife who implemented patient safety. there are 11 people (57.9%), and the physical workload of midwife who are light in total there are 3 people who apply good patient safety there are 3 people (100%). The results of the bivariate analysis obtained p value = 0.034 (<0.050), thus it can be said that there is a significant (significant) relationship between the physical workload of midwife and the application of patient safety.Conclusions and Suggestions: There is a significant (significant) relationship between the physical workload of midwife and the application of patient safety at the RSUD Kabupaten Bekasi. It is hoped that the results of this study will serve as objective information regarding the relationship between the physical workload of midwife and the application of patient safety. Midwife are expected to further improve the application of patient safety in accordance with the procedures applicable in the hospital.
Which Treatment Method Is Better in the Treatment of Chronic Plantar Fasciitis: Corticosteroid Injection, Extracorporeal Shock Wave Therapy, or Radiofrequency Thermal Lesioning?
Authors: Yapici Furkan , Gur Volkan , Sari Ilker Fatih , Karakose Resit , Tardus Ismail , Ucpunar Hanifi 
Published: November 2023

Background: Chronic plantar fasciitis (CPF) is a common disease that has various treatment options. This study aimed to compare the effectiveness of three of these options: corticosteroid injection (CSI), extracorporeal shock wave therapy (ESWT), and radiofrequency thermal lesioning (RTL).
Methods: The records of 229 patients treated with CSI (n = 81), ESWT (n = 76), or RTL (n = 72) were retrospectively analyzed. Visual analog scale scores, patient satisfaction–related success rates, repeated treatment rates, and initial treatment change rates were compared.
Results: Mean ± SD follow-up was 19.0 ± 4.5 months. Baseline clinical characteristics, mean visual analog scale scores (before treatment and at months 3, 6, and 12), patient satisfaction and success rates (at months 6 and 12), and repeated treatment and initial treatment change rates were similar between treatment groups. No complications were observed after the treatments.
Conclusions: All three options—CSI, ESWT, and RTL—were found to be safe and effective in treating CPF, with similar outcomes up to 1 year. Use of CSIs is advantageous because it is more accessible than the other treatments. Similarly, the noninvasive nature of ESWT is glaring among other minimally invasive options. Therefore, the first-line treatment modality of CPF can be CSI or ESWT, depending on the patient's and physician's joint preference; RTL treatment should be tried in patients who do not respond to these treatments.
RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells
Authors: Tian Xin , Zhou Guangli , Li Hao , Zhang Xueting , Zhao Lingmin , Zhang Keyi , Wang Luqiao , Liu Mingwei , Liu Chen , Yang Ping 
Published: November 2023

Background
Alternative splicing (AS) is a biological process that allows genes to be translated into diverse proteins. However, aberrant AS can predispose cells to aberrations in biological mechanisms. RNA binding proteins (RBPs), closely affiliated with AS, have gained increased attention in recent years. Among these RBPs, RBM25 has been reported to participate in the cardiac pathological mechanism through regulating AS; however, the involvement of RBM25 as a splicing factor in heart failure remains unclarified.

Methods
RBM25 was overexpressed in H9c2 cells to explore the target genes bound and regulated by RBM25 during heart failure. RNA sequencing (RNA-seq) was used to scrutinize the comprehensive transcriptional level before identifying AS events influenced by RBM25. Further, improved RNA immunoprecipitation sequencing (iRIP-seq) was employed to pinpoint RBM25-binding sites, and RT-qPCR was used to validate specific genes modulated by RBM25.

Results
RBM25 was found to upregulate the expression of genes pertinent to the inflammatory response and viral processes, as well as to mediate the AS of genes associated with cellular apoptosis and inflammation. Overlap analysis between RNA-seq and iRIP-seq suggested that RBM25 bound to and manipulated the AS of genes associated with inflammation in H9c2 cells. Moreover, qRT-PCR confirmed Slc38a9, Csf1, and Coro6 as the binding and AS regulatory targets of RBM25.

Conclusion
Our research implies that RBM25 plays a contributory role in cardiac inflammatory responses via its ability to bind to and regulate the AS of related genes. This study offers preliminary evidence of the influence of RBM25 on inflammation in H9c2 cells.