bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of hepatic toxicity in autoimmune hemolytic anemia (AIHA) and Evans syndrome patients: a single-center Egyptian study
Authors: Abozeid Fatma , Shaaban Yasmine , Elbogdady Mohamed , Jamal Esraa 
Published: February 2024

Abstract
Introduction
Benign auto-immune illnesses include Evans syndrome (ES) and auto-immune hemolytic anemia (AIHA). Despite being benign in nature, the patients’ livers are burdened by the disease’s chronicity and the accompanying problems beyond the course of treatment. An additional burden stems from HCV infection, of which a significant proportion of Egyptians are positive. The purpose of this study was to identify the hepatotoxicity risks and the variables that influence the prognosis and survival of patients with AIHA/ES. There are 126 AIHA patients in this observational study, which is retrospective. From June 2009 to March 2021, patients visited the Haematology Unit of the Oncology Centre in Egypt. One hundred and sixteen patients have available data.

Results
There was no significant difference between primary and secondary AIHA groups as regards baseline hemoglobin (Hb), bilirubin, LDH, or reticulocyte count. Thirty-four patients (29.31%) had HCV-positive tests and 1 patient (0.9%) had HBV. There was no difference between HCV-positive and negative cases as regards mean Hb concentration, mean platelet, or immune markers (P > 0.05). AIHA patients with HCV-positive showed a significantly higher relapse rate (56%) than HCV-negative patients (32%) (P = 0.034). HCV positivity and low platelet counts at diagnosis were poor predictors for overall survival (OS) (P 0.022 and 0.04, respectively). Median OS was significantly better in patients with no viral hepatitis infection (1101 days, 95% CI 592–2068) than in patients with positive HCV infection (521, 95% CI 326–1325) (P = 0.019).

Conclusions
Azathioprine is the least hepatotoxic in AIHA patients under treatment. Viral hepatitis represents a superadded damage to the liver besides AIHA concerning clinical characteristics and outcomes.
Neurosurgical emergencies in spinal tumors: pathophysiology and clinical management
Authors: Faraj Christina Abi , Snyder Rita I. , Tatsui Claudio E. , McCutcheon Ian E. 
Published: February 2024

AbstractWhether they are spinal metastases or primary spinal neoplasms, spinal tumors cause a myriad of complications given their critical location. Spinal tumors can be extradural, intradural extramedullary, or intramedullary, with extradural metastatic tumors the most commonly encountered. Spinal cord and/or cauda equina compression is one of the most devastating complications of cancer and represents a true oncologic emergency. Patients present with progressive paralysis, paresthesiae, and/or autonomic dysfunction. In addition to spinal cord compression (SCC), extradural spinal tumors can cause mechanical spinal instability and axial loading pain which often warrant surgical consultation. The diagnosis of SCC begins with clinical suspicion even before neurological deficits ensue. Patients presenting with back or neck pain who have a history of cancer should be evaluated carefully for SCC. MRI is the imaging modality of choice. Management of SCC generally requires a multidisciplinary approach, with goals of symptom control and prevention of irreversible functional loss. Patients with metastatic epidural SCC who undergo surgical decompression and reconstruction followed by radiotherapy exhibit better outcomes in preservation of function and symptom control than do those undergoing radiotherapy alone. Recent advances in the surgical management of SCC include minimally invasive spinal surgery (MISS), spinal laser interstitial thermotherapy (SLITT), and vertebral augmentation of pathologic vertebral compression fractures. Generally, SCC in patients with cancer serves as evidence of uncontrolled and aggressive disease. Although it is associated with poor outcome in most patients, effective palliation is possible with early diagnosis and careful application of modern surgical techniques for the elimination of cord compression, prevention or reversal of neurological deficits, and restoration of mechanical spinal stability. In addition to SCC from spinal tumors, other spinal complications can be seen in cancer patients who develop spine infections such as surgical site infection (SSI), spinal epidural abscesses (SEA), subdural empyema (SDE), or vertebral osteomyelitis. These complications can be due to inoculation from the spinal surgery itself or as a result of the patients’ immunocompromised state. This article provides a scoping review of the clinical presentation, pathophysiology, and diagnosis of major spinal oncologic emergencies and summarizes current modes of surgical and nonsurgical management.
Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination
Authors: O'Brien Oisín , Arumuham Atheeshaan , Mizuno Yuya , Baxter Luke , Lobo Maria , Parmar Sita , Jolles Stephen , Howes Oliver D. 
Published: February 2024

Summary
This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine.
Touch and Voice inAbsalom, Absalom!
Authors: Spillers Hortense J. , Arac Jonathan 
Published: February 2024

AbstractWilliam Faulkner constructed Absalom, Absalom! with techniques that allowed him to reach beyond his time and place to a historical grasp of problems that arise from a long past and that continue to shape our world nearly a century after the novel's publication. This essay explores that achievement through a double focus: touch and the intricate phenomenology of human sensory experience, combined with voice and the interplay of writing, speaking, and thinking in language.
Maxillary first premolar shape (and not size) as an indicator of sexual dimorphism: A 2D geomorphometric study
Authors: Natarajan Srikant , Ahmed Junaid , Jose Nidhin Philip , Shetty Shravan 
Published: February 2024

Introduction The primary aim of the study is to evaluate the morphological form of the maxillary first premolar using 2D geomorphometry and evaluate the sexually dimorphic characteristics. Methods The present study was carried out on standardized photographs of right Maxillary first premolar from 120 dental casts (60 male and 60 females). Twenty landmarks (based on geometric and anatomic evidence) were marked on the tooth using TPSdig software and analysed using Morpho J applying procrustes analysis and discriminant function analysis. Results The results showed similar centroid sizes between gender (p = 0.541). Procrustes ANOVA for shape analysis showed a greater dimorphism between sexs (f value of 1.35; p value=0.0793). Discriminant function analysis based on the procrustes coordinates showed an overall accuracy of 74.2 % in classifying sex based on the landmark coordinates with correct classification of 48/60 (80.00%) females and 41/60 (68.33) males. Conclusion Shape of the tooth can be measured objectively using geometric morphometric methods which can be utilized to identify the sex of an individual. The enamel is derived from ectoderm and once formed does not change during the life. The tooth’s structure and shape are determined by the sex chromosomes, which is well represented as sexual dimorphism. The study evaluates the occlusal and contact area morphology of premolars. These are important parameters considered during restorative treatment, functional rehabilitation and forensic investigations.
Is rest-activity rhythm prospectively associated with all-cause mortality in older people regardless of sleep and physical activity level? The ‘Como Vai?’ Cohort study
Authors: Wendt Andrea , Bielemann Renata Moraes , Wehrmeister Fernando C. , Ricardo Luiza I. C. , Müller Werner de Andrade , Machado Adriana Kramer Fiala , da Cruz Maurício Feijó , Bertoldi Andréa D. , Brage Soren , Ekelund Ulf , Tovo-Rodrigues Luciana , Crochemore-Silva Inácio 
Published: February 2024

Objective
This study aims to test the association of rest-activity rhythm (intradaily variability and interdaily stability) with all-cause mortality in an older adult cohort in Brazil. It also assesses whether the amount of time spent at each intensity level (i.e., physical activity and nocturnal sleep) interferes with this association.

Methods
This cohort study started in 2014 with older adults (≥60 years). We investigated deaths from all causes that occurred until April 2017. Rest-activity rhythm variables were obtained using accelerometry at baseline. Intradaily variability indicates higher rhythm fragmentation, while interdaily stability indicates higher rhythm stability. Cox proportional-hazard models were used to test the associations controlling for confounders.

Results
Among the 1451 older adults interviewed in 2014, 965 presented valid accelerometry data. During the follow-up period, 80 individuals died. After adjusting the analysis for sociodemographic, smoking, morbidity score, and number of medicines, an increase of one standard deviation in interdaily stability decreased 26% the risk of death. The adjustment for total sleep time and inactivity did not change this association. On the other hand, the association was no longer significant after adjusting for overall physical activity and moderate to vigorous physical activity.

Conclusion
Rest-activity rhythm pattern was not associated with mortality when physical activity was considered, possibly because this pattern could be driven by regular exercise. Promoting physical activity remains a relevant strategy to improve population health.
Expectation-practice discrepancies: a transcultural exploration of Chinese students’ oral discourse socialization in German academia
Authors: Long Yao 
Published: February 2024

Abstract
Analysis of German-based studies reveals a common interpretation of Chinese students’ adaptation to German academia, depicting them as learners with limited participation and critical thinking capacities. This perception stems from the perceived contrast between Confucian values, which emphasize social power distance and collectivism, and German academic expectations that prioritize values such as critical thinking and direct communication of personal perspectives. To challenge these assumptions, this study employs a transcultural analysis that explores quantitatively and qualitatively the oral discourse socialization of Chinese students in German universities. By applying Hofstede’s cultural dimensions, the research reinforces the presence of cross-cultural disparities in Oral Academic Presentation (OAP)-related expectations between China and Germany. Furthermore, by centering the voices of this student cohort and their transcultural perspective, the study presents a novel insight into their silent participatory approach and critical thinking mode, thereby challenging the prevailing generalized assumptions within German academia. This study underscores the necessity of moving beyond binary dichotomies that may inadvertently overlook the diversity of interpretations. Furthermore, the research underscores the importance of academic staff recognizing and legitimizing the diversity of students from the same culture and adjusting their teaching practices to address their evolving needs and interests in multicultural classroom settings.
Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging
Authors: Liu Shu-Hsiang , Lin Wei-Chun , Liao En-Chih , Lin Yung-Feng , Wang Ching-Shuen , Lee Sheng-Yang , Pei Dee , Hsu Chun-Hsien 
Published: February 2024

Abstract
The skin is subjected to various external factors that contribute to aging including oxidative stress from hydrogen peroxide (H2O2). This study investigated the distribution of aquaporin-8 (AQP8), a protein that transports H2O2 across biological membranes, in skin cells, and its effects in mitigating H2O2-induced oxidative damage. Human dermal fibroblasts were treated with increasing concentrations of H2O2 to evaluate oxidative damage. Cell viability, reactive oxygen species (ROS) generation, and the expression of specific genes associated with skin aging (IL-10, FPR2, COL1A1, KRT19, and Aggrecan) were evaluated and AQP8 expression was assessed via quantitative polymerase chain reaction and western blotting. Small-interfering RNA was used to silence the AQP8 gene and evaluate its significance. The results show that H2O2 treatment reduces cell viability and increases ROS generation, leading to oxidative damage that affects the expression of target molecules. Interestingly, H2O2-treated cells exhibit high levels of AQP8 expression and gene silencing of AQP8 reverses high levels of ROS and low levels of COL1A1, KRT19, and Aggrecan expression in stressed cells, indicating that AQP8 plays a vital role in preventing oxidative damage and consequent aging. In conclusion, AQP8 is upregulated in human dermal fibroblasts during H2O2-induced oxidative stress and may help prevent oxidative damage and aging. These findings suggest that AQP8 could be a potential therapeutic target for skin aging. Further research is necessary to explore the feasibility of using AQP8 as a preventive or therapeutic strategy for maintaining skin health.
A new method to estimate the partition of corrosion inhibitors
Authors: Hernández Zarate Kenia A. , Guzmán Castañeda Jesús I. , Cosmes López Liliana J. , Hallen-López José M. , Cabrera-Sierra Roman 
Published: February 2024

AbstractThe partitioning coefficient of the R12Na corrosion inhibitor is determined by relating its concentration in the water phase (CW) to the expected theoretical concentration (Ci,T) due to a re-concentration phenomenon after the mixing stage. Partition experiments were performed by varying the water cut in brine-kerosene mixtures, temperature, and the inhibitor concentration using NACE 1D182 brine as a water phase and ultraviolet-visible spectrophotometry. The partition results varied from 37.81 to 43.75 %, 36.68 to 61.23 %, and 40.29 to 56.47 % at 40 °C, 60 °C, and 80 °C, respectively, indicating that R12Na is a water soluble inhibitor and dispersible in the organic phase. Likewise, the partition results varied from 41.69 to 44.04 % in the presence of 20, 50, and 100 mg L−1of the inhibitor, using a ratio of 80–20 vol% WP–OP and 60 °C. Furthermore, making the same considerations, the partition of different corrosion inhibitors reported in the literature was evaluated, supporting its determination, the latter is of great importance for dosing corrosion inhibitors in the oilfield industry.
Nominalizations and its grammaticalization in standard Thai
Authors: Li Aliang 
Published: February 2024

AbstractThe focus of this study is on the function and grammaticalization of nominalizations in Thai and the nominalization categories and nominalizing strategies in Thai are described. The Thai language exhibits a composite of derivational and clausal nominalizations marked with three nominalizers:kaan1derives nouns or nominalized clauses from lexical verbs and relative or complement clauses;khwaam1derives nouns from lexical verbs and adjectives; andkaan1thii3is used for clauses. The current study posits diachronic developments for nominalizers and addresses related issues. It is concluded that nominalizerskaan1andkhwaam1were originally lexical nouns meaning ‘work’ and ‘matter’. The essential features of the use of nominalizations have remained constant, but certain developments have occurred, which include lexical nominalization to clausal nominalization and the emergence of a new nominalizer,kaan1thii3. It is found that nominalizerskaan1,khwaam1andkaan1thii3are basically in complementary distribution, and language internal evolution and external contact are the primary motivations for nominalization in Thai.
Constructicon in progress
Authors: Hoffmann Thomas 
Published: February 2024

AbstractOver the last forty years, Construction Grammar has emerged as the leading syntactic theory in cognitive linguistics. Usage-based versions of Construction Grammar have successfully been used to explain language acquisition, change, and variation. How the theory can be applied in foreign language teaching, however, has only recently attracted scholarly attention (De Knop and Gilquin 2016; Boas 2022). As part of this enterprise, the Constructionist Approach to Syntactic Analysis (CASA; Herbst and Hoffmann 2018, 2024) offers a new model that enables language teachers and students to analyse the most complex naturally occurring sentences. In the present paper, I will provide a short introduction to the CASA model. In addition to this, I will illustrate how this approach not only allows for a descriptive analysis of sentences, but how it offers teachers and students important theoretic insights into the cognitive nature of language.
“I’m gonna get totally and utterly X-ed.” Constructing drunkenness
Authors: Sanchez-Stockhammer Christina , Uhrig Peter 
Published: February 2024

AbstractThe English language is famous for its large number of drunkonyms, i.e. words that can be used to refer to the state of drunkenness – fromblindandhammeredtopissed,smashedandwasted. Various lists of words have been compiled in the past (e.g. Levine 1981). However, most of the terms seem to be relatively infrequent, and they also appear to fall out of use relatively quickly. In view of Michael McIntyre’s (2009) claim that it is possible to use any word to mean ‘drunk’ in English, this contribution therefore approaches the issue from a constructionist perspective. In a corpus-based study, we tested whether it is possible to model the expression of drunkenness in English as a more or less schematic (set of) construction(s). Our study shows that while corpus evidence for truly creative uses is scarce, we can nonetheless identify constructional and collostructional properties shared by certain patterns that are used to express drunkenness in English. For instance, the patternbe/get+ ADV + drunkonym is strongly associated with premodifying (and often strongly intensifying) adverbs such ascompletely,totallyandabsolutely. A manual analysis of a large wordlist of English drunkonyms reveals further interesting patterns that can be modelled constructionally.
Implicaciones económicas de la inestabilidad laboral: Un estudio de caso sobre el interinazgo en la Universidad Nacional de Costa Rica
Authors: Rodríguez Soto Maritza , Solís Bastos Laura 
Published: February 2024

This article addresses, through the stories of the population hired on an interimbasis at the National University of Costa Rica, the economic implicationsthat are the result of this working condition; such as: constant delays in theappointment and delays in the deposit of the salary, which have an impact onthe payment of the monthly family expenses, report of rates in the pensionsystem, count of the working time served; among others.The economic implications of interinazgo are reflected in the family and personalenvironment; reason why survival strategies are used to face economiccommitments. While in the workplace it affects the ability to focus on the task for which they have been hired, due to their constant economic concerns, and instability associated with the interinazgo, while much of their energy, time and attention is invested in the economic survival The words of the interviewed population show feelings of fear in the face of labor and economic instability that limits the plans to the future and therefore the concretion of these; Therefore, institutional policy and university bodies must develop mechanisms that favor the working conditions of this population.
Desarrollo de la investigación científica mediante el Trabajo Final de Graduación en tres titulaciones de grado de la Facultad de Ciencias Sociales, Universidad Nacional
Authors: Araya Muñoz Isabel , Majano Benavides Jilma 
Published: February 2024

This study was designed to determine the scope and incidence of the new scientific knowledge generated by the Final Graduation Projects researchprocess, carried out by students as a final graduation requirement for obtaining the bachelor’s degree in the major under study: Office Administration, Business Education at the School of Professional Secretarial and Administration with emphasis on Financial Management and Human Resources Management at the Administration Unit. We analyze in depth the characteristics of all the final graduation of project the three majors during the period 2014 to 2019. This qualitative research in the database to make an account of the final graduation project characteristics. The sample is intentional and at the convenience of the researchers to generate inputs for the investigation project: Principles and conditions of scientific analysis, technological and innovation development in the teaching-learning processes in subjects of three bachelor’s degrees in Social Sciences. A documentary review is made to each document, and with it, the main data to produce the data analysis. An interrelationship is made between the research topics, the methodological design, the construction of the theoretical framework, the issuance of information analysis, conclusions, and recommendations to finally make the proposal or alternative solution. This type of study strengthens the articulation between the different major of the social sciences because it allows to explore, recognize, quantify, and qualify the contribution of generating scientific knowledge of students through their final graduation report. It shows that it is necessary to continue innovating in research topics that respond to the organizational environment, it is imperative the articulated integration among different disciplines of the social sciences, and to give continuity to the proposals that suggest monitoring the execution and quality management of these proposals.
Avances y desafíos del Sistema Multilateral del Comercio en materia de Comercio Electrónico
Authors: Fonseca Arguello Hugo , Mora Vega Roy , Bermúdez Monge Derick 
Published: February 2024

When talking about electronic commerce, it is important to emphasize on how the use of the internet has become part of our daily culture and a necessityfor today’s societies, thus generating development in economies around the world and serving as a means of rapprochement between companies andconsumers that, although performed remotely, does not neglect closeness to the customer, creating comfort and access to a greater quantity of goods andservices. With its extensive growth and diversification, we find ourselves with the question of whether as member countries of the World Trade Organization(WTO), we can promote a flow of electronic commerce and its constant evolution, being one of the main tasks in which this organization can create or promote a legal framework where the access to this commercial channel allows equitable accessibility to more goods and services. Therefore, it is of utmost importance for this issue to be considered a priority and, despite the challenges it entails, as nations of the world we should enter into negotiations so electronic commerce and its benefits are not diminished by a framework that does not suit its characteristics, but rather tries to adapt to the versatility and evolution of new technologies.