bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus recommendations on the use of injectable poly‐l‐lactic acid in Asian patients
Authors: Avelar Luiz , Ong Amanda , Ong David , Wai Anthony Chui Shing , Wai Arthur Yu Tsz , Sungkyu Jung , Seok Lim Han , Tam Elias , Leng Shiau Ee , Huang Jeff , Chao Yates , Bråsäter Daniel , Prygova Inna 
Published: October 2023

AbstractBackgroundInjectable poly‐L‐lactic acid (PLLA) has been proven safe and effective with numerous medical applications for more than 25 years. The product has been approved in over 40 countries and is being used for soft tissue augmentation in the face and certain body parts. With the increased demand for subtle and natural‐looking aesthetic treatments in the Asia‐Pacific region, there is also a heightened need for consistent preparation and effective treatment methodologies to optimize outcomes for Asian patients.MethodsThe body of evidence in medical literature, clinical data of presented case reports, and the collective experience of the authors are reflected in these consensus recommendations, which also take under consideration the availability of biostimulators in the Asia‐Pacific region.ResultsThe resulting consensus recommendations include patient selection and assessment, management of treatment expectations, appropriate preparation and storage, proper injection techniques and treatment plans, management of adverse effects, PLLA combination with other facial rejuvenation procedures, and other constructive considerations.ConclusionsIn the above consensus recommendations, the authors shared their best practices in accordance with the updated preparation and treatment protocols of PLLA. These recommendations represent the clinical and real‐world techniques utilized by authors in providing PLLA treatments for Asian patients.
Treatment outcomes of early‐stage endometrial cancer patients: A propensity score matching of vaginal brachytherapy versus pelvic radiotherapy
Authors: Petsuksiri Janjira , Setakornnukul Jiraporn , Berpan Aniwat , Thephamongkhol Kullathorn , Dankulchai Pittaya , Jaishuen Atthapon 
Published: October 2023

AbstractObjectivesThis study aimed to report the treatment outcomes of radiation therapy for early‐stage endometrial cancer patients. In addition, this study intended to identify high‐risk factors that require pelvic radiotherapy (PRT) in addition to vaginal brachytherapy (VBT) for intermediate‐risk endometrial cancer patients.MethodsPatients with early‐stage endometrial cancer receiving postoperative VBT alone or with PRT were included. Propensity score matching was used to balance the two study groups. The primary endpoint was locoregional recurrence (LRR). Age‐adjusted Charlson comorbidity index and substantial lymphovascular space invasion were selected for subgroup analyses to identify the benefits of PRT over VBT alone.ResultsFrom 2005 to 2017, a total of 288 patients underwent analysis following propensity score matching. Of these, 144 received VBT and 144 received PRT. There was no significant difference in 5‐year LRR between VBT and PRT for both intermediate (0% vs. 0%) and high‐intermediate risk patients (3.5% VBT vs. 5.4% PRT; HR 0.54: 0.05–6.00; p = 0.616). The subgroup analyses revealed no significant factors favoring PRT over VBT. Patients with high comorbidities may have higher risks of non‐cancer death after receiving PRT.ConclusionsPostoperative VBT alone is sufficient for early‐stage intermediate‐risk endometrial cancer patients.
Too late to buy a home? School redistricting and the timing and extent of capitalization
Authors: Ding Xiaozhou , Bollinger Christopher , Clark Michael , Hoyt William 
Published: October 2023

AbstractIn the past 50 years, a voluminous literature estimating the value of schools through capitalization in home prices has emerged. Prior research has identified capitalization using a variety of approaches including discontinuities caused by boundaries. Here, we use changes in school boundaries and the opening of a new school in Fayette County (Lexington), Kentucky to identify this capitalization. Critical to properly estimating the effect of redistricting is to account for when information on redistricting is available. We treat the information about the effects of zoning as occurring in three stages: announcement of the intent to open the new high school and redistricting, approval of the specific redistricting plan (map), and implementation (opening of the new high school and actual changes in boundaries). We find significant changes in values for homes redistricted from lower‐performing schools and we find that this capitalization occurs well before implementation of the redistricting. As we show, failure to account for capitalization occurring before implementation will attenuate and even change the sign of capitalization.
Does hepatitis delta virus have a preference for hepatitis B virus genotype? A systematic review of the literature
Authors: Beghin Justine , Meier‐Stephenson Vanessa 
Published: October 2023

AbstractHepatitis delta virus (HDV) is a deficient virus that requires the surface proteins of Hepatitis B virus (HBV) to complete its replication. HDV is thus only found in those already infected with HBV (~5% worldwide). There are eight different HDV genotypes (1–8) and 10 HBV genotypes (A–J), each having fairly distinct geographic distributions. While their pairings may be coincidental based on epidemiological occurrence, some evidence exists regarding possible virologic basis for genotype dominance and patterns. Here we sought to determine which HBV genotype is most often linked with active HDV infection and speculate on whether this may represent a viral ‘preference’. Electronic databases with OVID Medline were comprehensively searched for studies published between 1977 and 2022 indexing the word ‘genotype’ and all permutations of ‘HDV’ (hepatitis D virus, hepatitis delta, etc.). Primary studies of patient samples reporting genotype data for either or both of HDV and HBV were tabulated. The initial search revealed 419 articles and was narrowed to 133 studies reporting genotype data for either or both HBV and HDV. We limited our search to cases with detectable HDV RNA. These represented over 5800 samples from over 70 countries. Of these, 1947 samples had paired genotype data for both viruses. The most common pairing was HDV‐1 with HBV‐D, but it remains unclear whether this represents a viral ‘preference’ or mere co‐endemicity of the two viruses. Determining if there is a virologic link between HBV and HDV genotypes may have important implications for emerging HDV and HBV research.
Prevalence and clinical relevance of cholelithiasis in cats: A multicenter retrospective study of 98 cases
Authors: Brunet Audrey , Duperrier‐Simond Cyril , Amoyal Suzanne , Benchekroun Ghita , Hernandez Juan , Lecot Lorris , Lurier Thibaut , Cadoré Jean‐Luc , Krafft Emilie 
Published: October 2023

AbstractBackgroundCholelithiasis is an uncommon and mainly incidental finding in dogs; current literature on this topic is scarce in cats.HypothesisReport prevalence, clinical presentation, management, and outcome of cholelithiasis in cats.AnimalsNinety‐eight cats with cholelithiasis.MethodsRetrospective multicenter case series. Electronic databases from 3 hospitals were searched for cats diagnosed with cholelithiasis by ultrasonography (US). Cholelithiasis was classified as incidental (IC) or symptomatic (SC) depending on clinicopathological signs, biliary tract US appearance, and presence of another disease potentially explaining the clinical presentation. Multivariate analysis was used to investigate factors associated with clinical expression of cholelithiasis and, within the SC group, survival.ResultsThe observed prevalence of cholelithiasis was 0.99% (95% confidence interval [CI], 0.79%‐1.19%) among cats that underwent abdominal US. Cholelithiasis was classified as IC in 41% and SC in 59%. Choleliths found in multiple locations within the biliary tract (odds ratio [OR], 8.11; 95% CI, 2.32‐34.15; P = .001) or associated with US signs of obstruction (OR, 18.47; 95% CI, 2.13‐2413.34; P = .004) were significantly associated with SC. Concurrent hepatobiliary diseases were suspected or confirmed in 83% of cases with SC. Forty‐three cats (74%) with SC survived to discharge. Biliary tract obstruction (BTO) was negatively associated with survival (OR, 13.87; 95% CI, 1.54‐124.76; P = .001). None of the cats with IC that had available follow‐up (47%) developed clinicopathological signs related to cholelithiasis.Conclusions and Clinical ImportanceCholelithiasis is uncommon and can be asymptomatic in cats. Symptomatic cholelithiasis frequently is associated with another hepatobiliary disease or BTO or both. Biliary tract obstruction is associated with poorer outcome.
Feminization, Ageing, and Occupational Change in Europe in the Last 25 Years
Authors: Mariscal‐de‐Gante Álvaro , Palencia‐Esteban Amaia , Grubanov‐Boskovic Sara , Fernández‐Macías Enrique 
Published: October 2023

AbstractThis paper presents new evidence on the interaction between demographic and occupational change in Europe over the last 25 years. We use data from the European Union Labour Force Survey covering six European countries. The analysis is based on a cross‐sectional comparison between the population and employment distributions in 1995 and 2019. This strategy allows us to study the changing demographic dynamics, which have brought a more feminized, aged, and educated working population, in a context of structural employment change, where higher job polarization or occupational upgrading are the main patterns. The results indicate that the increasing female participation has been associated with a strong general process of occupational upgrading that particularly benefited women. Still, the occupational profile of women is polarized relative to men. Although the process of educational upgrading was also stronger for women and overall they improved their occupational profile more than that of men, we find declining occupational returns to higher education for female workers in two countries. Finally, while European labor markets could accommodate the large increase in older workers, their occupational profile suffered some downgrading.
ZmNRT1.1B (ZmNPF6.6) determines nitrogen use efficiency via regulation of nitrate transport and signalling in maize
Authors: Cao Huairong , Liu Zhi , Guo Jia , Jia Zhongtao , Shi Yandong , Kang Kai , Peng Wushuang , Wang Zhangkui , Chen Limei , Neuhaeuser Benjamin , Wang Yong , Liu Xiangguo , Hao Dongyun , Yuan Lixing 
Published: October 2023

SummaryNitrate (NO3−) is crucial for optimal plant growth and development and often limits crop productivity under low availability. In comparison with model plant Arabidopsis, the molecular mechanisms underlying NO3− acquisition and utilization remain largely unclear in maize. In particular, only a few genes have been exploited to improve nitrogen use efficiency (NUE). Here, we demonstrated that NO3−‐inducible ZmNRT1.1B (ZmNPF6.6) positively regulated NO3−‐dependent growth and NUE in maize. We showed that the tandem duplicated proteoform ZmNRT1.1C is irrelevant to maize seedling growth under NO3− supply; however, the loss of function of ZmNRT1.1B significantly weakened plant growth under adequate NO3− supply under both hydroponic and field conditions. The 15N‐labelled NO3− absorption assay indicated that ZmNRT1.1B mediated the high‐affinity NO3−‐transport and root‐to‐shoot NO3− translocation. Transcriptome analysis further showed, upon NO3− supply, ZmNRT1.1B promotes cytoplasmic‐to‐nuclear shuttling of ZmNLP3.1 (ZmNLP8), which co‐regulates the expression of genes involved in NO3− response, cytokinin biosynthesis and carbon metabolism. Remarkably, overexpression of ZmNRT1.1B in modern maize hybrids improved grain yield under N‐limiting fields. Taken together, our study revealed a crucial role of ZmNRT1.1B in high‐affinity NO3− transport and signalling and offers valuable genetic resource for breeding N use efficient high‐yield cultivars.
Effects of niacin supplementation during in vitro culture on the developmental competence of porcine embryos
Authors: Almubarak Areeg , Osman Rana , Lee Joohyeong , Yu Il‐Jeoung , Jeon Yubyeol 
Published: October 2023

AbstractNiacin is a water‐soluble vitamin belonging to the vitamin B complex. It has been found to possess various biological activities, including antioxidant and lipid modification capacities. This study aimed to elucidate the effects of niacin treatment in porcine in vitro culture (IVC) medium on embryo developmental competence after parthenogenetic activation. IVC medium was supplemented with different concentrations of niacin (0 [control], 300, 600 and 900 μM). The results showed that embryos cultured in an IVC medium supplemented with 300 and 600 μM niacin had an increased cleavage rate (p < .05). In addition, 300 μM niacin treatment resulted in a higher blastocyst formation rate than the control and other niacin‐treated groups. However, the total cell number did not differ significantly among the experimental groups. Niacin supplementation at 600 μM decreased reactive oxygen species, whereas treatment with 300, 600 and 900 μM increased glutathione levels in day two embryos. On day seven, 300 μM niacin exhibited improved fatty acid levels and fewer lipid droplets than the control group. Furthermore, gene expression at the mRNA level was performed on day two and day seven embryos, treated with or without 300 μM niacin. The expression of anti‐apoptotic BCL2 and lipid metabolism PLIN2‐related genes were upregulated, whereas the pro‐apoptotic BAX and CASPASE3 were downregulated with niacin supplementation compared with the control group. However, SIRT1, a gene related to energy and the oxidative state, was up‐regulated in niacin‐treated day two embryos (p < .05). Overall, the results indicate that niacin has a beneficial effect on pre‐implantation embryo development by modulating lipid metabolism and reducing oxidative stress and apoptosis. The expression patterns of PLIN2 and SIRT1 reported here suggest that these transcripts may be involved in the mechanism by which niacin affects the developmental capacity of IVC embryos.
Extracting and classifying exceptional COVID‐19 measures from multilingual legal texts: The merits and limitations of automated approaches
Authors: Egger Clara , Caselli Tommaso , Tziafas Georgios , Phalle Eugénie de Saint , Vries Wietse de 
Published: October 2023

AbstractThis paper contributes to ongoing scholarly debates on the merits and limitations of computational legal text analysis by reflecting on the results of a research project documenting exceptional COVID‐19 management measures in Europe. The variety of exceptional measures adopted in countries characterized by different legal systems and natural languages, as well as the rapid evolution of such measures, pose considerable challenges to manual textual analysis methods traditionally used in the social sciences. To address these challenges, we develop a supervised classifier to support the manual coding of exceptional policies by a multinational team of human coders. After presenting the results of various natural language processing (NLP) experiments, we show that human‐in‐the‐loop approaches to computational text analysis outperform unsupervised approaches in accurately extracting policy events from legal texts. We draw lessons from our experience to ensure the successful integration of NLP methods into social science research agendas.
Shallow‐marine calciclastic mass‐transport deposits in an evolving thrust‐top basin: A case study from the North Dalmatian foreland basin, Croatia
Authors: Gobo Katarina , Mrinjek Ervin , Ćosović Vlasta , Ramov Roko , Vlatković Karla 
Published: October 2023

AbstractMass‐transport deposits are products of resedimentation phenomena involving a broad spectrum of gravity‐driven processes, and commonly have a high preservation potential in deep‐marine environments. This study documents various types of mass‐transport deposits that are interbedded with intensely bioturbated shallow‐marine calciclastic sediments deposited along a reflective coast during the middle and late Eocene. The sedimentary succession, located in the vicinity of Novigrad in northern Dalmatia, Croatia, comprises sediments deposited in a range of nearshore and carbonate ramp environments, and represents the infill of a thrust‐top (piggyback) basin of the North Dalmatian foreland basin. Five types of mass‐transport deposits, ranging in thickness from 13 cm to 6 m, have been identified: (i) calcilutite and calcarenite slumps; (ii) conglomeratic slump‐debrites with a ‘dough‐like’ appearance; (iii) blocky‐flow deposits bearing large blocks of beachface and/or shoreface deposits; (iv) rockfall deposits comprising scattered blocks of beachface conglomerates and shoreface calcarenites; and (v) ‘classical’ matrix‐supported debrites. Calciturbidites are rare and mainly comprise Ta and Tb divisions. Conglomeratic slump‐debrites are mostly found in association with offshore‐transition deposits, suggesting that mass flows were triggered above the storm‐wave base likely due to a combined effect of: (i) strong earthquakes related to the tectonic development of the basin; (ii) sediment destabilization due to pore‐water overpressure during forced regressions; and (iii) storm‐wave loading affecting the shallow seabed. Progressive deepening likely favoured mass‐flow transformations, although the overall paucity of turbidites suggests relatively short mass‐flow transport distance and turbidity current bypass to deeper realms. Multiple erosion phases and resedimentation processes from the Cretaceous to the late Eocene contributed to the diverse suite of extraformational clasts in the mass‐transport deposits studied. The mass‐transport deposits may be triggered and emplaced in shallow‐marine settings mainly during regressive stages of basin development, as the diverse gravel clast composition suggests significant tectonic influence. Although the mass‐transport deposits reported herein are relatively small, some of their peculiar sedimentary features and occurrence within shallow‐marine calciclastic deposits render them rather unique and suitable for a re‐assessment of the nature and evolutionary continuum of processes involved in subaqueous sediment mass transport, as well as the preservation potential of sedimentary features in high‐energy wave‐reworked environments.
Hip and knee kinematics, center of pressure position, and ground reaction force are associated with Achilles tendon force during jump landing
Authors: Koshino Yuta , Ishida Tomoya , Taniguchi Shohei , Samukawa Mina , Kasahara Satoshi , Tohyama Harukazu 
Published: October 2023

AbstractPurposeJump‐landing exercises are often performed during the rehabilitation of Achilles tendon (AT) injuries. However, the factors that affect the AT force (ATF) during landing are unclear. This study aimed to determine the kinematics and ground reaction force (GRF) variables associated with the peak ATF during a drop vertical jump (DVJ).MethodsThe landing phase of DVJ was evaluated in 101 healthy participants (46 males, age: 21.2 ± 1.4 years old) using a three‐dimensional motion analysis system with two force plates. ATF was estimated from the ankle flexion angle and moment. Univariate and multivariate regression analyses were performed with the peak ATF as the dependent variable. The vertical GRF (VGRF), center of pressure (COP), forward trunk leaning, hip/knee/ankle joint angles at peak ATF, and sex were used as independent variables.ResultsIn the univariate regression analysis, larger VGRF (β = 0.813), more anterior COP position (β = 0.214), smaller knee flexion (β = −0.251) and adduction (β = −0.252), smaller hip flexion (β = −0.407), smaller forward trunk lean (β = −0.492), and male sex (β = −0.282) were significantly associated with a larger peak ATF. Multivariate analysis revealed that larger VGRF (β = 1.018), more anterior COP position (β = 0.320), a larger knee (β = 0.442), and smaller hip flexion (β = −0.205) were associated with the larger peak ATF.ConclusionsThe VGRF, COP position, and knee and hip flexion were independently associated with ATF. Modifying these factors may be useful in managing tendon loading during jump‐landing exercises.
African firms in global value chains: What can we learn from firm‐level data in Cameroon and Côte d'Ivoire?
Authors: Coulibaly Romaric , Moreno Heddie , Suwa‐Eisenmann Akiko , Traore Nouhoum 
Published: October 2023

AbstractThe paper offers a detailed review of African firms' participation to international value chains and provides new quantitative insights on two countries, Cameroon and Ivory Coast, based on a unique dataset, which was obtained by merging firm census and detailed customs transactions over time. “GVC firms” are defined as firms that both export and import, with positive production and labour. The paper characterises GVC firms in the two countries. GVC firms represent about 15% of manufacturing firms; they are more frequent than pure exporters, a sign of the challenges faced by firms in those countries if they want to sell abroad. In line with the literature on firm heterogeneity and trade, firms engaged in GVCs are larger, more productive and live longer than one‐way‐traders or domestic firms. African markets are the main destination of manufacturing GVCs in Ivory Coast, while Cameroon GVC firms rely on OECD (including for agricultural exports). There is limited cross‐penetration between African‐oriented and OECD‐oriented GVC firms over time. The probability of moving into a GVC is higher for exporters than for importers, showing that exporting is a stepping stone for African firms to join a GVC.
Reinforcement Learning Based Aircraft Controller Enhanced By Gaussian Process Trim Finding
Authors: Benyamen Hady , Chowdhury Mozammal , Keshmiri Shawn 
Published: October 2023

Abstract
This work presents mathematical and practical frameworks for designing deep deterministic policy gradient (DDPG) flight controllers for fixed-wing aircraft. The aim is to design reinforcement learning (RL) flight controllers and accelerate training by substituting the six degrees-of-freedom aircraft models with linear time-invariant (LTI) dynamic models. The initial validation flight tests of the DDPG RL flight controller exhibited poor performance. Post-flight test investigation revealed that the unsatisfactory performance of the RL flight controller could be attributed to the high reliance of the LTI model on accurate control trim values and the substantial errors observed in the predicted trim values generated by the engineering-level dynamic analysis software. A complementary real-time learning Gaussian process (GP) regression was designed to mitigate this critical shortcoming of the LTI-based RL flight controller. The GP estimates and updates the trim control surfaces using observed flight data. The GP regression method incorporates real-time corrections to the trim control surfaces to enhance the performance of the flight controller. Flight test validation was repeated, and the results show that the RL controller, bolstered by the GP trim-finding algorithm, can successfully control the aircraft with excellent tracking performance.