bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tungsten–Iron–Ruthenium Ternary Alloy Immobilized into the Inner Nickel Foam for High‐Current‐Density Water Oxidation
Authors: Fan Xiyue , Zhang Chunyu , Chen Zhigang , Liu Tong , Yang Guang , Hou Shuang , Zhu Chengfeng , Liu Jinxun , Xu Jiaqiang , Qiao Fen , Cui Yi 
Published: January 2024

AbstractThe pursuit of highly‐active and stable catalysts in anodic oxygen evolution reaction (OER) is desirable for high‐current‐density water electrolysis toward industrial hydrogen production. Herein, a straightforward yet feasible method to prepare WFeRu ternary alloying catalyst on nickel foam is demonstrated, whereby the foreign W, Fe, and Ru metal atoms diffuse into the Ni foam resulting in the formation of inner immobilized ternary alloy. Thanks to the synergistic impact of foreign metal atoms and structural robustness of inner immobilized alloying catalyst, the well‐designed WFeRu@NF self‐standing anode exhibits superior OER activities. It only requires overpotentials of 245 and 346 mV to attain current densities of 20 and 500 mA cm−2, respectively. Moreover, the as‐prepared ternary alloying catalyst also exhibits a long‐term stability at a high‐current‐density of 500 mA cm−2 for over 45 h, evidencing the inner‐immobilization strategy is promising for the development of highly active and stable metal‐based catalysts for high‐density‐current water oxidation process.
Energizing Co Active Sites via d‐Band Center Engineering in CeO2‐Co3O4 Heterostructures: Interfacial Charge Transfer Enabling Efficient Nitrate Electrosynthesis
Authors: Li Shuyuan , Li Jingxian , Wang Xiaoxuan , Sun Yanfei , Tang Zheng , Gao Xueying , Zhang Huiying , Xie Jiangzhou , Yang Zhiyu , Yan Yi‐Ming 
Published: January 2024

AbstractThe electrochemical nitrogen oxidation reaction (NOR) holds significant potential to revolutionize the traditional nitrate synthesis processes. However, the progression in NOR has been notably stymied due to the sluggish kinetics of initial N2 adsorption and activation processes. Herein, the research embarks on the development of a CeO2‐Co3O4 heterostructure, strategically engineered to facilitate the electron transfer from CeO2 to Co3O4. This orchestrated transfer operates to amplify the d‐band center of the Co active sites, thereby enhancing N2 adsorption and activation dynamics by strengthening the Co─N bond and diminishing the resilience of the N≡N bond. The synthesized CeO2‐Co3O4 manifests promising prospects, showcasing a significant HNO3 yield of 37.96 µg h−1 mgcat−1 and an elevated Faradaic efficiency (FE) of 29.30% in a 0.1 m Na2SO4 solution at 1.81 V versus RHE. Further substantiating these findings, an array of in situ methodologies coupled with DFT calculations vividly illustrate the augmented adsorption and activation of N2 on the surface of CeO2‐Co3O4 heterostructure, resulting in a substantial reduction in the energy barrier pertinent to the rate‐determining step within the NOR pathway. This research carves a promising pathway to amplify N2 adsorption throughout the electrochemical NOR operations and delineates a blueprint for crafting highly efficient NOR electrocatalysts.
Identifying High Gleason Score Prostate Cancer by Prostate Fluid Metabolic Fingerprint‐Based Multi‐Modal Recognition
Authors: Peng Zehong , Wang Yuning , Wu Xinrui , Yang Shouzhi , Du Xinxing , Xu Xiaoyu , Hu Cong , Liu Wanshan , Zhu Yinjie , Dong Baijun , Pan Jiahua , Bao Qingui , Qian Kun , Dong Liang , Xue Wei 
Published: January 2024

AbstractProstate cancer (PCa) is the second most common cancer in males worldwide. The Gleason scoring system, which classifies the pathological growth pattern of cancer, is considered one of the most important prognostic factors for PCa. Compared to indolent PCa, PCa with high Gleason score (h‐GS PCa, GS ≥ 8) has greater clinical significance due to its high aggressiveness and poor prognosis. It is crucial to establish a rapid, non‐invasive diagnostic modality to decipher patients with h‐GS PCa as early as possible. In this study, ferric nanoparticle‐assisted laser desorption/ionization mass spectrometry (FeNPALDI‐MS) to extract prostate fluid metabolic fingerprint (PSF‐MF) is employed and combined with the clinical features of patients, such as prostate‐specific antigen (PSA), to establish a multi‐modal diagnosis assisted by machine learning. This approach yields an impressive area under the curve (AUC) of 0.87 to diagnose patients with h‐GS, surpassing the results of single‐modal diagnosis using only PSF‐MF or PSA, respectively. Additionally, using various screening methods, six key metabolites that exhibit greater diagnostic efficacy (AUC = 0.96) are identified. These findings also provide insights into related metabolic pathways, which may provide valuable information for further elucidation of the pathological mechanisms underlying h‐GS PCa.
Revised taxonomy for two species complexes of Western Australian Isopogon (Proteaceae) using RADseq
Authors: Anderson Benjamin M. , Binks Rachel M. , Byrne Margaret , Davis Robert , Hislop Michael , Rye Barbara L. 
Published: January 2024

AbstractThe Australian genus Isopogon (Proteaceae) consists of approximately 39 species, most of which occur in southwestern Australia, a region of considerable endemism and biodiversity. Unresolved taxonomic issues exist for two species complexes (nine suspected taxa) allied to I. spathulatus and I. polycephalus. There is uncertainty in how to delimit species in these two complexes due to unclear or overlapping morphological characters, although recognition of four phrase‐named taxa provide starting hypotheses for potential new taxa. We used a genomic approach (ddRAD) to generate SNPs for 146 samples from 32 populations across the two complexes to evaluate the genomic distinction of taxa and delimit species. We used an optimised ipyrad assembly of the sequenced libraries, followed by custom filtering of samples and SNPs for ordination, genetic structure, distance and concatenation and coalescent phylogenetic analyses. Population genetic and phylogenetic analyses consistently supported three geographically overlapping yet genomically distinct groups, two of which showed additional genomic divergence consistent with multiple distinct species. Existing morphological hypotheses were congruent with genomic groupings in some cases but discordant in others, where genomic admixture suggested existing taxa were conspecific. Evaluating morphological characters, geographic distribution and genomic distinction, we recognise five species and three subspecies from nine original taxa. We provide a key to species in the complexes and related taxa, updated descriptions for existing taxa, and describe two new species, I. elatus sp. nov. and I. pallidus sp. nov., and two new subspecies, I. spathulatus subsp. obovatus stat. nov. and I. spathulatus subsp. elongatus subsp. nov.
Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications
Authors: Dadhwal Gunjan , Samy Hebatallah , Bouvette Jonathan , El-Azzouzi Fatima , Dagenais Pierre , Legault Pascale 
Published: January 2024

AbstractThe human let-7 miRNA family consists of thirteen members that play critical roles in many biological processes, including development timing and tumor suppression, and their levels are disrupted in several diseases. Dicer is the endoribonuclease responsible for processing the precursor miRNA (pre-miRNA) to yield the mature miRNA, and thereby plays a crucial role in controlling the cellular levels of let-7 miRNAs. It is well established that the sequence and structural features of pre-miRNA hairpins such as the 5′-phosphate, the apical loop, and the 2-nt 3′-overhang are important for the processing activity of Dicer. Exceptionally, nine precursors of the let-7 family (pre-let-7) contain a 1-nt 3′-overhang and get mono-uridylated in vivo, presumably to allow efficient processing by Dicer. Pre-let-7 are also oligo-uridylated in vivo to promote their degradation and likely prevent their efficient processing by Dicer. In this study, we systematically investigated the impact of sequence and structural features of all human let-7 pre-miRNAs, including their 3′-end modifications, on Dicer binding and processing. Through the combination of SHAPE structural probing, in vitro binding and kinetic studies using purified human Dicer, we show that despite structural discrepancies among pre-let-7 RNAs, Dicer exhibits remarkable promiscuity in binding and cleaving these substrates. Moreover, the 1- or 2-nt 3′-overhang, 3′-mono-uridylation, and 3′-oligo-uridylation of pre-let-7 substrates appear to have little effect on Dicer binding and cleavage rates. Thus, this study extends current knowledge regarding the broad substrate specificity of Dicer and provides novel insight regarding the effect of 3′-modifications on binding and cleavage by Dicer.
Stationsapotheker:innen in der Intensivmedizin: ökonomische Nutzenanalyse
Authors: Liebing Nadja , Ziehr Benjamin , Röber Susanne , Nibbe Lutz , Oppert Michael , Warnke Ulrich 
Published: January 2024

Zusammenfassung
Hintergrund
Der positive Einfluss pharmazeutischer Betreuung auf die Verbesserung der Arzneimitteltherapiesicherheit gilt als belegt. Zum ökonomischen Nutzen klinisch pharmazeutischer Dienstleistungen in Deutschland ist bisher wenig bekannt.

Ziel der Arbeit
Im Klinikum Ernst von Bergmann wurde 2020 ein Pilotprojekt zur Einführung von Stationsapotheker:innen in der Intensivmedizin gestartet, in dem auch der finanzielle Nutzen des angebotenen Medikationsmanagements ermittelt werden sollte.

Methodik
Jeder pharmazeutischen Intervention (PI) wurde durch ein Team aus erfahrenen Intensivmediziner:innen und Stationsapotheker:innen im Konsensprinzip ein Wahrscheinlichkeitswert (Nesbit-probability-Score) zugeordnet, mit dem ein unerwünschtes Arzneimittelereignis (UAE) aufgetreten wäre. Unter der Annahme, dass pro UAE eine verlängerte Liegedauer resultiert, wurden die durchschnittlichen Fallkosten der Intensivstation/Tag als Einsparungspotenzial herangezogen. Das Modell kombiniert dabei die Ergebnisse zweier internationaler Publikationen, um eine ökonomische Bilanzierung pharmazeutischer Dienstleistungen zu ermöglichen.

Ergebnisse
Im Untersuchungszeitraum wurden 177 PI ausgewertet und entsprechende Wahrscheinlichkeitswerte für das Eintreten von UAE ermittelt. Daraus wurden durch vermiedene Kosten jährliche Einsparungen von 80.000 € berechnet.

Schlussfolgerung
In diesem Projekt konnte der ökonomische Nutzen pharmazeutischer Dienstleistungen in der Intensivmedizin belegt werden. Stationsapotheker:innen sind nun fester Bestandteil des intensivmedizinischen Behandlungsteams im Klinikum Ernst von Bergmann.
The physical, mechanical, and chemical properties of black cherry tree wood (Prunus serotina Ehrh.) and its susceptibility to fungal decomposition in areas where it is secondary and invasive: a case study in the Kampinos National Park (Poland)
Authors: Marciszewska Katarzyna , Szczepkowski Andrzej , Lachowicz Hubert , Antczak Andrzej , Szadkowska Dominika , Suchodolski Jakub 
Published: January 2024

AbstractThe properties of black cherry mature wood (Prunus serotina Ehrh.) and its susceptibility to fungal decay were studied in the invaded range of the species on six trees aged between 39 and 47 years old growing in poor, acidic soils with varying levels of moisture and organic carbon and nitrogen content. Wood from trees that grew in wetter and richer soil had better physical properties. Of the 95 parameters analyzed, 80 showed significant differences in favor of this wood. These differences included wider rings that averaged 3.25 mm, a higher density of 662.71 kg/m3 at 12% humidity, and 1.5 times higher content of extractives. Gas chromatography with mass spectrometry revealed the presence of 44 extractives. Out of these, six had antifungal properties and were found in the wood of trees grown in richer soil, corresponding to 62.93% of the peaks area of all identified substances. Only three were found in trees grown in poorer soil, corresponding to 8.68% of the peaks area respectively. The wood of trees grown in more fertile soil was also less prone to fungal decay, which was generally low. Only Trametes versicolor caused a mass loss of more than 10% of the wood in both sites out of the four basidiomycete species tested. The results indicate that even slight variations in soil fertility and moisture can benefit black cherry, leading to differences in wood features and properties in its exotic range.
The BPHZ Theorem for Regularity Structures via the Spectral Gap Inequality
Authors: Hairer Martin , Steele Rhys 
Published: January 2024

AbstractWe provide a relatively compact proof of the BPHZ theorem for regularity structures of decorated trees in the case where the driving noise satisfies a suitable spectral gap property, as in the Gaussian case. This is inspired by the recent work (Linares et al. in A diagram-free approach to the stochastic estimates in regularity structures, 2021. arXiv:2112.10739) in the multi-index setting, but our proof relies crucially on a novel version of the reconstruction theorem for a space of “pointed Besov modelled distributions”. As a consequence, the analytical core of the proof is quite short and self-contained, which should make it easier to adapt the proof to different contexts (such as the setting of discrete models).
Control of motor output during steady submaximal contractions is modulated by contraction history
Authors: Darendeli Abdulkerim , Enoka Roger M. 
Published: January 2024

AbstractThe purpose of the study was to investigate the influence of contraction history on force steadiness and the associated EMG activity during submaximal isometric contractions performed with the dorsiflexor muscles. The key feature of the protocol was a triangular ramp contraction performed in the middle of a steady contraction at a lower target force. The target force during the ramp contraction was 20% MVC greater than that during the steady contraction. Thirty-seven healthy individuals (21 men and 16 women) performed the submaximal tasks with the ankle dorsiflexors. Electromyography (EMG) signals were recorded from tibialis anterior with a pair of surface electrodes. The coefficient of variation for force was significantly greater during the second steady contraction compared with the first one at each of the seven target forces (p < 0.015; d = 0.38–0.92). Although the average applied force during the steady contractions before and after the triangular contraction was the same (p = 0.563), the mean EMG amplitude for the steady contractions performed after the triangular contraction was significantly greater at each of the seven target forces (p < 0.0001; d = 0.44–0.68). Also, there were significant differences in mean EMG frequency between the steady contractions performed before and after the triangular contraction (p < 0.01; d = 0.13–0.82), except at 10 and 20% MVC force. The greater force fluctuations during a steady submaximal contraction after an intervening triangular contraction indicate a change in the discharge characteristics of the involved motor units.
Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes
Authors: Deschamps Charlotte , Denis Sylvain , Humbert Delphine , Priymenko Nathalie , Chalancon Sandrine , De Bodt Jana , Van de Wiele Tom , Ipharraguerre Ignacio , Alvarez-Acero Inma , Achard Caroline , Apper Emmanuelle , Blanquet-Diot Stéphanie 
Published: January 2024

Abstract
Differences in dog breed sizes are an important determinant of variations in digestive physiology, mainly related to the large intestine. In vitro gut models are increasingly used as alternatives to animal experiments for technical, cost, societal, and regulatory reasons. Up to now, only one in vitro model of the canine colon incorporates the dynamics of different canine gut regions, yet no adaptations exist to reproduce size-related digestive parameters. To address this limitation, we developed a new model of the canine colon, the CANIne Mucosal ARtificial COLon (CANIM-ARCOL), simulating main physiochemical (pH, transit time, anaerobiosis), nutritional (ileal effluent composition), and microbial (lumen and mucus-associated microbiota) parameters of this ecosystem and adapted to three dog sizes (i.e., small under 10 kg, medium 10–30 kg, and large over 30 kg). To validate the new model regarding microbiota composition and activities, in vitro fermentations were performed in bioreactors inoculated with stools from 13 dogs (4 small, 5 medium, and 4 large). After a stabilization period, microbiota profiles clearly clustered depending on dog size. Bacteroidota and Firmicutes abundances were positively correlated with dog size both in vitro and in vivo, while opposite trends were observed for Actinobacteria and Proteobacteria. As observed in vivo, microbial activity also increased with dog size in vitro, as evidenced from gas production, short-chain fatty acids, ammonia, and bile acid dehydroxylation. In line with the 3R regulation, CANIM-ARCOL could be a relevant platform to assess bilateral interactions between food and pharma compounds and gut microbiota, capturing inter-individual or breed variabilities.

Key points
• CANIM-ARCOL integrates main canine physicochemical and microbial colonic parameters
• Gut microbiota associated to different dog sizes is accurately maintained in vitro
• The model can help to move toward personalized approach considering dog body weight
Antimicrobial activity of lipids extracted from Hermetia illucens reared on different substrates
Authors: Franco Antonio , Scieuzo Carmen , Salvia Rosanna , Pucciarelli Valentina , Borrelli Luca , Addeo Nicola Francesco , Bovera Fulvia , Laginestra Ambrogio , Schmitt Eric , Falabella Patrizia 
Published: January 2024

Abstract
As the problem of antimicrobial resistance is constantly increasing, there is a renewed interest in antimicrobial products derived from natural sources, particularly obtained from innovative and eco-friendly materials. Insect lipids, due to their fatty acid composition, can be classified as natural antimicrobial compounds. In order to assess the antibacterial efficacy of Hermetia illucens lipids, we extracted this component from the larval stage, fed on different substrates and we characterized it. Moreover, we analyzed the fatty acid composition of the feeding substrate, to determine if and how it could affect the antimicrobial activity of the lipid component. The antimicrobial activity was evaluated against Gram-positive Micrococcus flavus and Gram-negative bacteria Escherichia coli. Analyzing the fatty acid profiles of larval lipids that showed activity against the two bacterial strains, we detected significant differences for C4:0, C10:0, C16:1, C18:3 n3 (ALA), and C20:1. The strongest antimicrobial activity was verified against Micrococcus flavus by lipids extracted from larvae reared on strawberry, tangerine, and fresh manure substrates, with growth inhibition zones ranged from 1.38 to 1.51 mm, while only the rearing on manure showed the effect against Escherichia coli. Notably, the fatty acid profile of H. illucens seems to not be really influenced by the substrate fatty acid profile, except for C18:0 and C18:2 CIS n6 (LA). This implies that other factors, such as the rearing conditions, larval development stages, and other nutrients such as carbohydrates, affect the amount of fatty acids in insects.

Key points
• Feeding substrates influence larval lipids and fatty acids (FA)
• Generally, there is no direct correlation between substrate FAs and the same larvae FAs
• Specific FAs influence more the antimicrobial effect of BSF lipids

Graphical abstract
Meniscus root tears: state of the art
Authors: Hantouly Ashraf T. , Aminake Ghislain , Khan Anfal Sher , Ayyan Muhammad , Olory Bruno , Zikria Bashir , Al-Khelaifi Khalid 
Published: January 2024

Abstract
Background
Meniscus root tears represent significant pathology that, historically, has been underdiagnosed and undertreated. However, the recognition of their clinical and functional significance has recently surged, mainly due to their frequent association with anterior cruciate ligament injuries.

Aim
This comprehensive review discusses various aspects of meniscal root tears, including their epidemiology, biomechanics, etiology, clinical and radiological findings, classification, management and surgical techniques.
Graphical representation of data prediction potential: correlation graphs and correlation chains
Authors: Dudáš Adam 
Published: January 2024

AbstractThe correlation of the set of attributes is a crucial statistical value for the measuring of prediction potential present in a dataset. The correlation coefficient, which measures the correlation between the values of two attributes, can be used in order to measure the prediction potential between two-element subsets of a dataset containing a high number of attributes. In this way two common summary visualizations of prediction potential in datasets are formed—correlation matrices and correlation heatmaps. Both of these visualizations are focused on the presentation of correlation between pair of attributes but not much more regarding the context of correlations in the dataset. The main objective of this article is the design and implementation of graphical models usable in a visual representation of data prediction potential—correlation graphs and correlation chains—which emphasize the pseudo-transitivity of prediction potential in a dataset.
Neonatal intubation: what are we doing?
Authors: Maglio Sabina , Cavallin Francesco , Sala Chiara , Bua Benedetta , Villani Paolo Ernesto , Menciassi Arianna , Tognarelli Selene , Trevisanuto Daniele 
Published: January 2024

AbstractHow and when the forces are applied during neonatal intubation are currently unknown. This study investigated the pattern of the applied forces by using sensorized laryngoscopes during the intubation process in a neonatal manikin. Nine users of direct laryngoscope and nine users of straight-blade video laryngoscope were included in a neonatal manikin study. During each procedure, relevant forces were measured using a force epiglottis sensor that was placed on the distal surface of the blade. The pattern of the applied forces could be divided into three sections. With the direct laryngoscope, the first section showed either a quick rise of the force or a discontinuous rise with several peaks; after reaching the maximum force, there was a sort of plateau followed by a quick drop of the applied forces. With the video laryngoscope, the first section showed a quick rise of the force; after reaching the maximum force, there was an irregular and heterogeneous plateau, followed by heterogeneous decreases of the applied forces. Moreover, less forces were recorded when using the video laryngoscope. Conclusions: This neonatal manikin study identified three sections in the diagram of the forces applied during intubation, which likely mirrored the three main phases of intubation. Overall, the pattern of each section showed some differences in relation to the laryngoscope (direct or video) that was used during the procedure. These findings may provide useful insights for improving the understanding of the procedure.

What is Known:• Neonatal intubation is a life-saving procedure that requires a skilled operator and may cause direct trauma to the tissues and precipitate adverse reactions.• Intubation with a videolaryngoscope requires less force than with a direct laryngoscope, but how and when the forces are applied during the whole neonatal intubation procedure are currently unknown.

What is New:• Forces applied to the epiglottis during intubation can be divided into three sections: (i) an initial increase, (ii) a sort of plateau, and (iii) a decrease.• The pattern of each section shows some differences in relation to the laryngoscope (direct or videolaryngoscope) that is used during the procedure.