bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Thin, Stable, and Flexible Janus Lithium‐Textile Anode for Long‐Life and High‐Energy Lithium Metal Battery
Authors: Cai Jiehua , Wang Lei , Huang Qiyao , Yu Wancheng , Xie Chuan , Zheng Zijian 
Published: December 2023

AbstractEquipping thin lithium metal anodes (LMAs) in lithium metal batteries (LMBs) is essential to realize a high energy density of the battery. However, the cycling stability of thin LMAs, especially at high depth of discharge (DOD), is very poor. Here, the rapid preparation of stable and thin LMAs through selective wetting of molten lithium (Li) on a Janus structured conductive textile is reported, which yields a thin Li (∼3.0 mg cm−2) coating on one side of the conductive framework. This Janus Li‐textile composite anode not only significantly reduces the use of Li metal by 80% in comparison to the homogeneous composite anode, but also enhances the cycling stability via the Janus lithiophobic–lithiophilic framework and upper buffering space. At a high DOD of 75%, the Janus Li‐textile anode exhibits an ultralong cycle life over 3000 h. LMBs equipping with the Janus Li‐textile anode show an enhanced energy density by 30%, with a remarkable cycling life of 2000 cycles, and capacity retention of 99.94% per cycle.
Could trust narrow the intention‐behavior gap in eco‐friendly food consumption? Evidence from China
Authors: Yuan Rao , Jin Shaosheng , Lin Wen 
Published: December 2023

AbstractThere exists a potential gap between individual intention to purchase eco‐products and their actual purchase behaviors, which contributes to low eco‐friendly consumption. The study investigates the intention‐behavior gap in eco‐friendly food consumption, and how consumer trust affects the gap. We focus on consumer trust in eco‐friendly food regulator, manufacturer, certifier, and farmer. Evidence from Chinese consumers reveals that individuals with low trust in the certifier have high intention to purchase green food but fail to make actual purchases. Trust in the manufacturer is positively associated with actual purchases of organic food regardless of intention. We also find that trust exerts the greater impact in bridging the intention‐behavior gap among female, younger, more educated, and more environmentally conscious consumers. Our findings highlight the importance of consumer trust in the certifier and manufacturer. Implications for promoting eco‐friendly food consumption are discussed.
Late‐onset mucopolysaccharidosis type IIIA mimicking Usher syndrome
Authors: De Falco Alessandro , Karali Marianthi , Criscuolo Chiara , Testa Francesco , Barillari Maria Rosaria , Scarpato Margherita , Gaudieri Valeria , Cuocolo Alberto , Russo Anna , Nigro Vincenzo , Simonelli Francesca , Banfi Sandro , Brunetti‐Pierri Nicola 
Published: December 2023

AbstractMucopolysaccharidosis type IIIA (MPS IIIA or Sanfilippo syndrome type A) is an autosomal recessive lysosomal storage disorder caused by pathogenic variants in the SGSH gene encoding N‐sulfoglucosamine sulfohydrolase, an enzyme involved in the degradation of heparan sulfate. MPS IIIA is typically characterized by neurocognitive decline and hepatosplenomegaly with childhood onset. Here, we report on a 53‐year‐old male subject initially diagnosed with Usher syndrome for the concurrence of retinitis pigmentosa and sensorineural hearing loss. Clinical exome sequencing identified biallelic missense variants in SGSH, and biochemical assays showed complete deficiency of sulfamidase activity and increased urinary glycosaminoglycan excretion. Reverse phenotyping revealed left ventricle pseudo‐hypertrophy, hepatosplenomegaly, bilateral deep white matter hyperintensities upon brain MRI, and decreased cortical metabolic activity by PET‐CT. On neuropsychological testing, the proband presented only partial and isolated verbal memory deficits. This case illustrates the power of unbiased, comprehensive genetic testing for the diagnosis of challenging mild or atypical forms of MPS IIIA.
Challenges for interprofessional simulation‐based sedation training courses: Mini review
Authors: Komasawa Nobuyasu 
Published: December 2023

AbstractSedation for invasive procedures is given for various clinical purposes to patients of all ages worldwide. However, sedation is a continuum to general anesthesia and contains severe inherent risks leading to mortality. Providing a simulation‐based sedation training course (SEDTC) to various medical staff could be an effective strategy to improve patient and medical safety associated with sedation. The SEDTC generally includes basic airway management such as upper airway obstruction release or rapid response action toward excessive sedation, utilizing problem‐based learning or simulators. However, participation alone in the SEDTC can only achieve Level 1 (reaction) or 2 (learning) in the Kirkpatrick model. A patient safety improvement of Level 3 (transfer) or 4 (result) of the Kirkpatrick model can be achieved when all members related to sedation undergo experiential learning and reach a consensus. Accordingly, in‐hospital interprofessional SEDTC focusing on a resilience approach is essential to achieve effective sedation patient safety in Level 3 or 4 of the Kirkpatrick model.
Design of voltage stabilizers for high breakdown strength materials
Authors: Yu Decai , Mwasame Paul , Yu Xindi , Mukhopadhyay Sukrit , Rao Yuanqiao , Cogen Jeffrey , Person Tim 
Published: December 2023

AbstractHigh breakdown strength material in the cable insulation layer is a key enabler for high voltage power transmission. In this work, we seek to design high‐performance voltage stabilizers to be compounded into polyethylene to improve its breakdown strength. We hypothesize that electron affinity (EA) and HOMO‐LUMO gap are two key factors that affect the performance of voltage stabilizers. To achieve larger EA and smaller HOMO‐LUMO gap, we propose to use aromatic molecules decorated with electron acceptors and donors. A search of an internal chemical database narrows down to 529 molecules using structure, ClogP, and H‐phrases (hazard statement) as criteria. The EA and HOMO‐LUMO gap of these molecules are then calculated and experiments are carried out to measure the performance of 20 molecules. The performance improvement does not show a significant correlation with either EA or HOMO‐LUMO gap. However, the best performers have an EA of 1.3–2.3 eV and HOMO‐LUMO gap of 3.2–5.2 eV. The experimental study shows that adding side groups to voltage stabilizers will typically degrade their performance because side groups will generally increase the distance between the HOMO‐LUMO orbitals and polyethylene backbone, and therefore decrease the electron/hole tunneling effectiveness.
A novel fluorescent aptasensor for the detection of theophylline based on cryonase‐driven signal amplification strategy
Authors: Feng Tingting , Kang Zhechen , Yan Shuzhu , Huang Yu , Liu Rui 
Published: December 2023

AbstractIn the study, we have developed an expedient and efficient method for the detection of theophylline based on the amplification of the signal intensity of fluorescence based on oxidized single‐walled carbon nanohorns (oxSWCNHs)/cryonase. When theophylline was not present in the system, oxSWCNHs can adequately adsorb nucleic acid probes labeled by carboxyfluorescein (FAM). In the presence of theophylline, the nucleic acid probe forms the tertiary probe–theophylline complex, which detaches from the surface of the oxSWCNHs. Then, upon reaction with cryonase, the complex can release the FAM and theophylline into the next cycle. The fluorescence signal of the system exhibits a 1:N magnification, enabling quantitative detection of theophylline. The linear range was 30–150 ng/mL, and the limit of detection (LOD) was 6.04 ng/mL. At the same time, it can also be used to detect theophylline in mouse serum.
Transforming layered 2D mats into multiphasic 3D nanofiber scaffolds with tailored gradient features for tissue regeneration
Authors: Shahriar S. M. Shatil , Polavoram Navatha Shree , Andrabi Syed Muntazir , Su Yajuan , Lee Donghee , Tran Huy Quang , Schindler Samantha J. , Xie Jingwei 
Published: December 2023

AbstractMultiphasic scaffolds with tailored gradient features hold significant promise for tissue regeneration applications. Herein, this work reports the transformation of two‐dimensional (2D) layered fiber mats into three‐dimensional (3D) multiphasic scaffolds using a ‘solids‐of‐revolution’ inspired gas‐foaming expansion technology. These scaffolds feature precise control over fiber alignment, pore size, and regional structure. Manipulating nanofiber mat layers and Pluronic F127 concentrations allows further customization of pore size and fiber alignment within different scaffold regions. The cellular response to multiphasic scaffolds demonstrates that the number of cells migrated and proliferated onto the scaffolds is mainly dependent on the pore size rather than fiber alignment. In vivo subcutaneous implantation of multiphasic scaffolds to rats reveals substantial cell infiltration, neo tissue formation, collagen deposition, and new vessel formation within scaffolds, greatly surpassing the capabilities of traditional nanofiber mats. Histological examination indicates the importance of optimizing pore size and fiber alignment for the promotion of cell infiltration and tissue regeneration. Overall, these scaffolds have potential applications in tissue modeling, studying tissue‐tissue interactions, interface tissue engineering, and high‐throughput screening for optimized tissue regeneration.
Se‐Glargine: Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge
Authors: Weil‐Ktorza Orit , Dhayalan Balamurugan , Chen Yen‐Shan , Weiss Michael A. , Metanis Norman 
Published: December 2023

AbstractInsulin has long provided a model for studies of protein folding and stability, enabling enhanced treatment of diabetes mellitus via analogue design. We describe the chemical synthesis of a basal insulin analogue stabilized by substitution of an internal cystine (A6–A11) by a diselenide bridge. The studies focused on insulin glargine (formulated as Lantus® and Toujeo®; Sanofi). Prepared at pH 4 in the presence of zinc ions, glargine exhibits a shifted isoelectric point due to a basic B chain extension (ArgB31−ArgB32). Subcutaneous injection leads to pH‐dependent precipitation of a long‐lived depot. Pairwise substitution of CysA6and CysA11by selenocysteine was effected by solid‐phase peptide synthesis; the modified A chain also contained substitution of AsnA21by Gly, circumventing acid‐catalyzed deamidation. Although chain combination of native glargine yielded negligible product, in accordance with previous synthetic studies, the pairwise selenocysteine substitution partially rescued this reaction: substantial product was obtained through repeated combination, yielding a stabilized insulin analogue. This strategy thus exploited both (a) the unique redox properties of selenocysteine in protein folding and (b) favorable packing of an internal diselenide bridge in the native state, once achieved. Such rational optimization of protein folding and stability may be generalizable to diverse disulfide‐stabilized proteins of therapeutic interest.
Prior roasting of wheat impacts on the functionality of flour prepared from it: Part 2. Wheat protein functionality
Authors: van Rooyen Jana , Delcour Jan A. , Oyeyinka Samson A. , Simsek Senay , Kidd Martin , Manley Marena 
Published: December 2023

AbstractBackground and ObjectivesIn the accompanying paper (Part 1), it was reported that forced convection roasting of wheat before milling can be directed to tailor the viscosifying properties of flour. The objective of the present work was to examine the effect of prior wheat roasting on flour proteins.FindingsEffective control of wheat roasting conditions proved to be essential to avoid the irreversible loss of flour functionality as deduced from the flour ethanol and lactic acid solvent retention capacity and mixography data. Response surface models predicted roasting at 108°C and 80 Hz (135 s) to maintain protein integrity. The microstructure of flour and isolated starch as well as X‐ray diffraction patterns revealed starch to be relatively unaffected by this heat treatment.ConclusionsFlour produced from roasted wheat can still be used for products that require the formation of a gluten network.Significance and NoveltyProtein is more sensitive to roasting conditions than starch.
Extension of the theory of adherence to treatment in patients with coronary heart disease
Authors: Kähkönen Outi , Vähänikkilä Hannu , Paukkonen Leila , Oikarinen Anne 
Published: December 2023

AbstractBackgroundIncreased knowledge of the concept of adherence is needed for development patient‐centered care, nursing interventions, and guidelines for patients with coronary heart disease (CHD). The aim of this study was to test and extend the Theory of Adherence to Treatment regarding informational support in patients with CHD.MethodsThe study utilized an explanatory and descriptive survey. The study was conducted in 2013 and involved 416 patients in five hospitals in Finland. The Adherence of Patients with Chronic Disease instrument and the Social Support for People with CHD instrument were used. The model was tested using structural equation modeling (SEM).ResultsSEM confirmed direct associations between motivation (β = 0.49, p < 0.001) and results of care (β = 0.29, p < 0.01), and indirect associations between sense of normality, fear of complications, support from nurses and next of kin, and informational support to adherence to a healthy lifestyle and medication. Informational support included information and advice on CHD risk factors, physical exercise, chest pain, medication, continuum of care, and rehabilitation. Indirect standardized path coefficients varied between 0.14 and 0.45. The model explained 45% of adherence to a healthy lifestyle and medication.ConclusionThe results of this study showed that informational support is a justified extension to the original Theory of Adherence to Treatment in Patients with CHD. Informational support seems to offer a new perspective that can be used to develop patient‐centered nursing interventions and thus support adherence to treatment by patients with a lifelong disease such as CHD.
Understanding the Role of Electrode Thickness on Redox Flow Cell Performance**
Authors: Muñoz‐Perales Vanesa , van der Heijden Maxime , de Haas Victor , Olinga Jacky , Vera Marcos , Forner‐Cuenca Antoni 
Published: December 2023

AbstractThe electrode thickness is a critical design parameter to engineer high performance redox flow cells by impacting the available surface area for reactions, current and potential distributions, and required pumping power. To date, redox flow cell assemblies employ repurposed off‐the‐shelf fibrous electrodes which feature a broad range of thicknesses. However, comprehensive guidelines to select the optimal electrode thickness for a given reactor architecture remain elusive. Here, we investigate the effect of the electrode thickness in the range of 200–1100 μm on the cell performance by stacking electrode layers in four different flow cell configurations – Freudenberg paper and ELAT cloth electrodes combined with flow‐through and interdigitated flow fields. We employ a suite of polarization, electrochemical impedance spectroscopy and pressure drop measurements together with pore network modeling simulations to correlate the electrode thickness for various reactor designs to the electrochemical and hydraulic performance. We find that thicker electrodes (420 μm paper electrodes and 812 μm cloth electrodes) are beneficial in combination with flow‐through flow fields, whereas when using interdigitated flow fields, thinner electrodes (210 μm paper electrodes and 406 μm cloth electrodes) result in a better current density and pressure drop trade‐off. We hope our findings will aid researchers and technology practitioners in designing their electrochemical flow cells under convective operation.
Enhancing Polymer Electrolyte Membrane Fuel Cells with Ionic Liquids: A Review
Authors: Liu Qingqing , Liu Huiyuan , Zhang Weiqi , Ma Qiang , Xu Qian , Hooshyari Khadijeh , Su Huaneng 
Published: December 2023

AbstractPolymer electrolyte membrane fuel cells (PEMFCs) represent a promising clean energy solution. However, their widespread adoption faces hurdles related to component optimization. This review explores the pivotal role of ionic liquids (ILs) in enhancing PEMFC performance, focusing on their role in polymer electrolyte membranes, catalyst modification, and other components. By addressing key obstacles, including proton conductivity, catalyst stability, and fuel crossover, ILs provide a pathway towards the widespread commercialization of PEMFCs. In the realm of PEMFC membranes, ILs have shown great potential in improving proton conductivity, mechanical strength, and thermal stability. Additionally, the utilization of ILs as catalyst modifiers has shown promise in enhancing the electrocatalytic activity of electrodes by serving as an effective stabilizer to promote the dispersion of metal nanoparticles, and reduce their agglomeration, thereby augmenting catalytic performance. Furthermore, ILs can be tailored to optimize the catalyst‐support interaction, ultimately enhancing the overall fuel cell efficiency. Their unique properties, such as high oxygen solubility and low volatility, offer advantages in terms of reducing mass transport and water management issues. This review not only underscores the promising advancements achieved thus far but also outlines the challenges that must be addressed to unlock the full potential of ILs in PEMFC technology, offering a valuable resource for researchers and engineers working toward the realization of efficient and durable PEMFCs.
Sauberer Wasserstoff aus Methanpyrolyse
Authors: Panchenko Alexander , Rieck Daniela , Flick Dieter , Hennig Gunnar , Bode Johannes , Rosendorfer Karin , Fölsch Sarah 
Published: December 2023

AbstractFür die Transformation der chemischen Industrie hin zu einer klimaneutralen Zukunft ist sauberer Wasserstoff essenziell. Die Bedeutung von Wasserstoff als Energieträger wird deutlich größer werden als die heutige stoffliche Nutzung. Dampfreformierung von Methan, das derzeit gängigste Verfahren zur Wasserstoffherstellung, ist mit hohen CO2‐Emissionen verbunden. Die Methanpyrolyse hingegen, deren Skalierung in einem BMBF‐geförderten Projekt vorangetrieben wird, ist eine innovative Technologie zur klimafreundlichen Produktion von Wasserstoff. Die großtechnische Anwendung der Methanspaltung soll nach erfolgreicher Skalierung ab 2030 einen wichtigen Beitrag zur Senkung der Treibhausgasemissionen in der chemischen Industrie leisten.
Personality disorder type only sometimes matters: An exploration of patient's personality disorder as a source of variance in early therapeutic alliance
Authors: Prusiński Tomasz 
Published: December 2023

AbstractObjectiveThe study aimed to analyse personality disorders among patients in the early phase of psychotherapy as a source of variance in the quality of the emerging alliance.MethodsThe sample consisted of 131 individual psychotherapy patients with borderline (BPD), narcissistic (NPD), dependent (DPD) and obsessive–compulsive (OCPD) personality disorders and 131 psychotherapists. Different sources of alliance estimation were included. Therapeutic alliance was operationalized on several dimensions. The hypothesis was tested using an independent samples one‐way analysis of variance.ResultsThe study revealed a significant effect of personality disorder type on early therapeutic alliance quality. BPD patients rated their early alliance the lowest compared to NPD, DPD and OCPD patients. This trend was dominant and replicated regardless of who rated the alliance and which dimension of alliance was estimated.ConclusionsNPD, DPD and OCPD patients have better initial therapeutic alliances than BPD patients, and their alliances do not differ significantly. BPD patients build weaker alliances, and what poses a challenge for them is not only developing a strong and close bond but also conceptualizing goals and reaching agreement on tasks.
Therapeutic frameworks in integration sessions in substance‐assisted psychotherapy: A systematised review
Authors: Thal Sascha B. , Baker Paris , Marinis Jonathon , Wieberneit Michelle , Sharbanee Jason M. , Bruno Raimundo , Skeffington Petra M. , Bright Stephen J. 
Published: December 2023

AbstractSerotonergic psychedelics and related substances have been explored as potential adjuncts in substance‐assisted psychotherapy (SAPT) for treating various disorders. SAPT can be divided into three phases: preparation, administration and integration. Integration is commonly defined as the comprehension and effective application of insights from psychedelic experiences into everyday life. However, there is limited research regarding the most appropriate therapeutic approach during SAPT. In this article, we discuss the current evidence for different therapeutic frameworks for integration sessions when serotonergic psychedelics and entactogens are used as adjuncts to psychotherapy. We conducted a systematised review of the literature following PRISMA guidelines and searched PsycINFO, MEDLINE and Cochrane Library databases. The final synthesis included 75 clinical trials, mixed‐methods investigations, treatment manuals, study protocols, quasi‐experiments, qualitative investigations, descriptive studies, opinion papers, reviews, books and book chapters, published until 11 November 2022. The effects that various therapeutic approaches for integration sessions have on therapeutic outcomes have not been investigated by means of rigorous research. Most of the available evidence we retrieved was not supported by empirical data, thus limiting any conclusive statements regarding appropriate therapeutic frameworks for integration sessions for SAPT. Current clinical studies have used a range of therapeutic frameworks with the majority drawing from the humanistic–experiential tradition. While integration is regarded as crucial for the safe application of SAPT, there is currently an insufficient evidence base to suggest that any type of therapy is effective for guiding integration sessions. A systematic investigation of different therapeutic frameworks for integration and additional therapy‐related factors is needed.