bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta‐analysis of the ability of mutational profiles on the cancer genome atlas to predict prognosis in endometrial carcinoma
Authors: Li Yi‐xiang , Fan Yu , Cao Si‐yu , Zhang Yu‐fei , Li Jin‐ke 
Published: January 2025

AbstractBackgroundIn 2013, The Cancer Genome Atlas Research Network suggested that endometrial carcinoma patients may be reclassified into four molecular prognostic groups.ObjectiveTo compare survival of endometrial carcinoma patients with different mutational profiles.Search StrategyStudies reporting survival of endometrial carcinoma patients were identified through systematic searches of four databases.Selection CriteriaWe included relevant studies based on the literature type, data integrity and the methodological quality.Data Collection and AnalysisThe pooled survival data were compared among patients with different mutational profiles. Heterogeneity in the pooled data was assessed using the I2 statistic.Main ResultsData were meta‐analyzed from nine studies involving 4755 patients, who were classified into the following mutational profiles: p53abn, 745 patients (15.6%); MMRd, 1454 patients (30.6%); POLEmut, 351 patients (7.4%); and p53wt, 2205 patients (46.4%). Compared to the p53wt group, the p53abn group showed significantly worse overall survival (OS) (HR 2.31, 95% CI: 1.67–3.19), progression‐free survival (PFS) (HR 2.86, 95% CI: 1.45–5.64) and disease‐specific survival (HR 2.60, 95% CI: 1.41–4.79); and the MMRd group showed significantly worse OS (HR 1.30, 95% CI: 1.11–1.53) and PFS (HR 1.27, 95% CI: 1.01–1.59). The POLEmut group, in contrast, showed similar survival as the p53wt group.ConclusionsThe four mutational profiles for patients with endometrial carcinoma in the Cancer Genome Atlas for Endometrial Cancer are associated with worse to better survival in the trend: p53abn < MMRd < POLEmut ≈ p53wt. Mutational profiling may be useful for stratifying endometrial carcinoma patients by survival risk, which in turn may improve their management.
Anti‐Müllerian hormone regulates ovarian granulosa cell growth in PCOS rats through SMAD4
Authors: Dong Anqi , Yu Xiaomeng , Zhang Yun , Liu Lili , Liu Fanglin , Song Wei , Zheng Jindan 
Published: January 2025

AbstractObjectivePolycystic ovary syndrome (PCOS) is a diverse condition with an unknown cause. The precise mechanism underlying ovulatory abnormalities in PCOS remains unclear. It is widely believed that malfunction of granulosa cells is the primary factor contributing to aberrant follicular formation in PCOS.MethodsA DHEA‐induced PCOS rat model was established, and ovarian granulosa cells were extracted and identified. Anti‐Müllerian hormone (AMH) and SMAD family member 4 (SMAD4) expression was detected in the serum, ovarian tissue and ovarian granulosa cells of each group, and proliferating cell nuclear antigen (PCNA), BCL2‐associated 2 (BAX), cleaved caspase‐3 and BCL‐2 protein expression was detected by Western blot in ovarian granulosa cells. Recombinant anti‐Müllerian hormone (rAMH) was administered at different concentrations to act on normal rat ovarian granulosa cells, cell proliferation was detected by cell counting kit‐8 (CCK‐8), apoptosis was detected by flow cytometry, and SMAD4, caspase‐3, BCL‐2 and cyclin A proteins were detected by Western blot. SMAD4‐siRNA was transfected into rat ovarian granulosa cells of the PCOS group, and PCNA and BAX were detected by Western blot.ResultsCompared with those in the control group, the expression of AMH and SMAD4 was increased in the ovarian tissues and granulosa cells of rats in the PCOS group, the expression of PCNA and BCL‐2 proteins was decreased in the ovarian granulosa cells of the PCOS group, the expression of BAX proteins was increased, and the expression of cleaved caspase‐3 was increased. Western blot results indicated that rAMH upregulated SMAD4 and caspase‐3 protein expression in granulosa cells and downregulated cyclin A and BCL‐2 protein expression. CCK‐8 and flow cytometry results indicated that AMH decreased granulosa cells proliferation and increased apoptosis. SiRNA knockdown of SMAD4 gene increased PCNA and BCL‐2 protein expression in the granulosa cells of PCOS rats and decreased BAX and cleaved caspase‐3 protein expression.ConclusionAMH may be involved in regulating impaired ovarian granulosa cells development in PCOS rats via SMAD4.
Optical Based Methods for Water Monitoring in Biological Tissue
Authors: Perkov Sergei , Cvjetinovic Julijana , Sydygalieva Altynai , Gorodkov Sergey , Li Guoqiang , Gorin Dmitry 
Published: January 2025

ABSTRACTSkin homeostasis is strongly dependent on its hydration levels, making skin water content measurement vital across various fields, including medicine, cosmetology, and sports science. Noninvasive diagnostic techniques are particularly relevant for clinical applications due to their minimal risk of side effects. A range of optical methods have been developed for this purpose, each with unique physical principles, advantages, and limitations. This review provides an in‐depth examination of optical techniques such as diffuse reflectance spectroscopy, optoacoustic spectroscopy, optoacoustic tomography, hyperspectral imaging, and Raman spectroscopy. We explore their efficacy in noninvasive monitoring of skin hydration and edema, which is characterized by an increase in interstitial fluid. By comparing the parameters, sensitivity, and clinical applications of these techniques, this review offers a comprehensive understanding of their potential to enhance diagnostic precision and improve patient care.
Regulatory Fragmentation and Operational Efficiency
Authors: Xu Hongkang 
Published: January 2025

ABSTRACTThis study employs a fragmentation index derived from Federal Register data to explore the relationship between regulatory fragmentation and operational efficiency. I find a positive association between regulatory fragmentation and operational efficiency, validated through various robustness checks, including entropy balancing, instrumental variable methods, fixed effects at different levels, change specification models, and alternative measures of operational efficiency. Additional analyses indicate that this positive association is more pronounced in firms exhibiting internal control weaknesses and facing higher operational uncertainty. Overall, my results suggest that although regulatory fragmentation poses challenges, it also creates opportunities for firms to enhance their operation efficiency. This research sheds light on the multifaceted effects of regulatory environments, providing valuable insights for policymakers and corporate strategists in managing regulatory complexities.
The Degree and Origin of the Cooperativity of the Chalcogen (Ch···N) and Dihydrogen (H···H) Bonds in Some Triad Systems
Authors: Soufi Aboulfazl , Salehzadeh Sadegh 
Published: January 2025

ABSTRACTThe strength and cooperative energy of chalcogen and dihydrogen bonds in some ABC triad systems of the types XHTe…NCH…HY (X = F, Cl, Br, I, H; Y = Li, Na, BeH, MgH) and FHCh…NCH…HNa (Ch = Te, Se, S) were computed and compared at several levels of theory. All resulting data showed that the strengths of chalcogen (Te…N) and dihydrogen (H…H) bonds increase in the order of H < I < Br < Cl < F, and Be < Mg < Li < Na, respectively. Then, the comparison of data for the FHTe…NCH…HY, FHSe…NCH…HNa, and FHS…NCH…HNa triads indicated that the interaction, stabilization, and cooperativity energies decrease in the order of Te > Se > S. The data show that in all cases the chalcogen and dihydrogen bonds change the bond dissociation energies (BDEs) and interaction energies (IEs) of each other by the same quantitative value. However, the relative impact of the above bonds on BDEs and IEs of each other depends on the relative strength of these bonds. Finally, the nature of both dihydrogen and chalcogen bonds and the origin of the cooperativity of bonds were evaluated by NBO and energy decomposition analysis (EDA) analyses.
Computational Insights Into Corrosion Inhibition Mechanism: Dissociation of Imidazole on Iron Surface
Authors: Zhao Weina , Shen Chang , Tummanapelli Anil Kumar , Wong Ming Wah 
Published: January 2025

ABSTRACTCorrosion inhibitors are widely used to mitigate safety risks and economic losses in engineering, yet post‐adsorption processes remain underexplored. In this study, we employed density functional theory calculations with a periodic model to investigate the dissociation mechanisms of imidazole on the Fe(100) surface. Imidazole was found to adsorb optimally in a parallel orientation, with an adsorption energy of −0.88 eV. We explored two dissociation pathways: CH and NH bond cleavages and found CH dissociation having a lower activation barrier of 0.46 eV. Intriguingly, an alternative indirect route CH dissociation pathway involving a tilted intermediate state was found to be competitive. Both indirect and direct CH dissociation pathways are energetically more favorable than NH cleavage. Molecular dynamics simulations reveal that indirect CH dissociation occurs rapidly. This study proposes an alternative protective mechanism involving dissociated imidazole inhibitors, offering new insights for corrosion inhibitor design.
Emotion and peer problems in autistic adolescents: The role of puberty, school adjustment and bullying
Authors: Dawe‐Lane Erin O. , Saunders Rob , Flouri Eirini , Mandy William P. L. 
Published: January 2025

AbstractBackgroundEmotion and peer problems tend to increase in autistic young people during adolescence. However, the extent to which endogenous (e.g., pubertal maturation) and exogenous (e.g., school adjustment, bullying) factors contribute to trajectories of emotion and peer problems in autistic young people is unclear.MethodsUsing data from the Millennium Cohort Study (MCS), we fitted latent growth curves to model initial levels and growth in emotion and peer problems during adolescence. We used generalised structural equation models to investigate whether pubertal maturation, school adjustment, bullying, and timing of autism diagnosis (none, early [<8 years] or late [≥8 years]) predict initial levels and growth of emotion and peer problems in autistic and non‐autistic young people, separately for males (n = 780) and females (n = 172).ResultsIn females, there were significant interactions between timing of diagnosis and (a) school adjustment and (b) bullying. In females with a late diagnosis of autism, lower school adjustment and greater bullying were associated with greater growth of emotion problems during adolescence. Furthermore, in females with an early diagnosis, lower school adjustment was associated with greater initial levels of peer problems. In males, later pubertal maturation was associated with greater growth of emotion and peer problems during adolescence, irrespective of autism diagnosis. In males with an early diagnosis of autism, greater bullying was associated with greater growth of emotion problems during adolescence.ConclusionSchool adjustment and bullying were associated with increasing emotion and peer problems in autistic adolescents, but their relative contribution varied according to timing of autism diagnosis and sex. Overall, this study supports the need for early identification and intervention for young autistic people experiencing poor school adjustment and bullying during adolescence.
The Development of Creativity: From Self‐to Socially‐Referenced
Authors: Dumas Denis 
Published: January 2025

ABSTRACTHow does creativity develop from a nearly ubiquitous and domain‐general capacity associated with playfulness and openness to experience to a highly rarified and domain‐specific ability associated with invention and innovation? In this short report, I describe creativity along two dimensions: self‐ and socially referenced creativity. In self‐referenced creativity, only the creators themselves judge the novelty and usefulness of an idea, while in socially referenced creativity, others make the judgments. For education to support creativity, it should therefore leverage (not squash) the self‐referenced creativity that learners enter schooling with, while simultaneously supporting learners in a transition to more socially referenced creativity within a domain. Based on the psychological characteristics of learners at different points in their academic development, I suggest activities that would be maximally fruitful in the process of developing domain creativity. Because these activities allow learners to engage their self‐referenced creativity but also require them to apply their domain knowledge to predict what others in the domain would view as novel or useful, they support the development of socially referenced creativity and exemplify the goals of creative education.
Circulating Tumor DNA as a Marker of Recurrence Risk in Stage III Colorectal Cancer: The α‐CORRECT Study
Authors: Diergaarde Brenda , Young Greg , Hall David W. , Mazloom Amin , Costa Gina L. , Subramaniam Soma , Palomares Melanie R. , Garces Jorge , Baehner Frederick L. , Schoen Robert E. ,   Exact Sciences MRD Group
Published: January 2025

ABSTRACTBackground and ObjectivesIdentification of colorectal cancer (CRC) patients at high risk of recurrence could be of substantial clinical use. We evaluated the association of ctDNA status, using a tumor‐informed assay, with recurrence‐free survival (RFS).MethodsStage III CRC patients were enrolled between 2016 and 2020. Tumor tissue and serial (every 3 months for years 1–3, biannually for years 4–5) blood samples were collected. Utilizing whole‐exome sequencing and selection of 50–200 variants for tumor informed assays, ctDNA status was determined using plasma cell‐free DNA.ResultsOf 137 patients enrolled, 124 with 1029 ctDNA results were included in the analyses. Median follow‐up was 4.8 years. Plasma ctDNA status was strongly associated with risk of recurrence during the surveillance period (hazard ratio (HR) 49.6, 95% CI: 16.6–148.3; p < 0.0001), and at the postsurgical (HR 9.6, 95% CI: 3.2–29.5) and postdefinitive therapy timepoints (HR: 16.7, 95% CI: 6.9–40.3). The estimated 3‐year RFS for ctDNA positive and ctDNA negative patients were, respectively, 54.5% and 96.1% after surgery, and 18.2% and 90.0% after definitive therapy. Multivariable analysis indicated ctDNA but not CEA was strongly prognostic for recurrence.ConclusionsOur tumor‐informed ctDNA assay was strongly prognostic for recurrence in patients with stage III colorectal cancer at all timepoints.
Electrochemical Synthesis of Polyaniline@Nano Zinc Oxide/Modified Multiwalled Carbon Nanotubes Nanocomposite Coating for Solid Phase Microextraction of Some Polycyclic Aromatic Hydrocarbons in Coffee and Grilled Meat
Authors: Baduee Rezvan Askari , Kazemipour Maryam , Ansari Mehdi , Mehdipour Mohammad , Mohamadi Neda 
Published: January 2025

ABSTRACTPolycyclic aromatic hydrocarbons (PAHs) are carcinogenic compounds resulting from incomplete burning of organic materials. This work describes the successful layer‐by‐layer fabrication of a novel zinc oxide nanocomposite made of zinc oxide nanoparticles, aniline, sodium dodecyl sulfate, and modified multi‐walled carbon nanotubes on a stainless steel wire by electrodeposition. The coating and extraction conditions were screened, optimized, and validated using factorial design and central composite design, respectively. The prepared nanocomposites were characterized by the Fourier‐transform infrared spectroscopy, field‐emission scanning electron microscopy, X‐ray diffraction analysis, and Brunauer‐Emmett‐Teller techniques. It featured a porous structure, excellent heat stability, and a high extraction capacity. It also adhered well to the steel surface. Extracting PAHs was optimized through experimental design. The optimal conditions obtained for extraction were 60 min, 30%, and 30°C for extraction time, amount of salt, and extraction temperature, respectively. The validated method generally showed a linear range between 0.01 to 1.50 µg/mL with a linearity of (R2) of 0.9902–0.9992, limits of detection less than 0.003 µg/mL, limit of quantification lower than 0.010 µg/mL, and relative standard deviation percent less than 45. Recovery values of the analytes in food samples varied between 53.4% and 110.1%. The proposed method was employed in the extraction and determination of some PAHs in some food samples while naphthalene, anthracene, phenanthrene, benzo[a]pyrene, and benz[a]anthracene were detected in certain food samples. Overall, our research suggests a novel nanocomposite as a potential fiber coating that enables high‐capacity PAH extraction.
Emergence of bullous pemphigoid under treatment of mycosis fungoides with mogamulizumab
Authors: Uleer Lukas D. , Loquai Carmen , Shimanovich Iakov , Khandanpour Cyrus , Pruessmann Jasper N. , Terheyden Patrick , Sadik Christian D. 
Published: January 2025

AbstractMycosis fungoides (MF) is the most common cutaneous T cell lymphoma. Since 2018, mogamulizumab, an antibody directed to to the chemokine receptor CCR4, is licensed for the treatment of MF. Treatment with mogamulizumab is associated with the precipiation of different types of skin rashes summarized as mogamulizumab‐associated rash. Here, we report the emergence of severe bullous pemphigoid (BP) in a patient suffering from severe MF and treated with mogamulizumab. BP is an autoimmune blistering skin disease causing severe pruritus and subepidermal blisters and, consequently, erosions. It is driven by autoantibodies against BP180, a protein of the dermal‐epidermal adhesion complex. The parallel occurrence of MF and BP led to a bizarre clinical and histopathological presentation blending features of MF and BP. Among others, the patient developed multiple large erosions with a diameter of up to 15 cm, and histopathology featured subepidermal clefts with a mixed dermal infiltrate and atypical lymphocytes forming a superficial dermal lichenoid infiltrate and showing epidermotropism, including above the subepidermal clefts. Immunopathology revealing linear depositions of IgG and C3 at the dermal‐epidermal junction and very high serum levels of anti‐BP180‐NC16A IgG were instrumental to diagnose BP and to distinguish it from mycosis fungoides bullosa, an extremely rare variant of MF. This case illustrates that immunopathology for BP should be conducted in patients with MF developing pruritus and blisters, although both can also be a symptom of MF. Our case alone does not allow determining whether the emergence of BP under mogamulizumab treatment was a mere coincidence or was in a causal relationship. The latter scenario would at BP to the possible clinical presentations of mogamulizumab‐associated rashes.
Broadband and High‐Resolution Mid‐Infrared Spectroscopy Enabled by a Single Phase Change Metasurface
Authors: Xu Yi , Li Yan , Zhong Ruifeng , Li Yu‐Ru , Li Qiang , Wang Dawei , Chen Zhenshi , Pan Jingshun , Li Zhaohui 
Published: January 2025

AbstractThe mid‐infrared (MIR) spectral region is crucial for various applications due to its unique properties, but traditional spectrometers are often bulky. Miniaturized spectrometers face a trade‐off between spectral and spatial resolution. Here, a novel approach to MIR spectroscopy is numerically demonstrated by employing an electrically controlled phase‐change metasurface. This method fully exploits the high optical contrast and the quasi‐continuous phase change characteristics of chalcogenide phase change materials, enabling the construction of a set of spectral responses that provide broad spectral coverage with low correlation, utilizing a single metasurface pixel. With this innovative strategy, a broadband and high‐resolution spectral reconstruction is numerically demonstrated with a full width at half maximum (FWHM) resolution of 20 nm and a dual‐peak resolution of 160 nm within a 2400 nm bandwidth. Furthermore, the potential of the spectral detection scheme is underscored by the successful numerical reconstruction of the absorption peaks of methane and carbon dioxide, highlighting its capability for gas analysis and molecular identification. The integration of the spectral detection method into the field of spectral imaging is anticipated to have significant implications, suggesting substantial improvements in chemical process monitoring, and rapid diagnostic techniques in combustion environments.
3D Printed Metamaterial Absorber Based on Vanadium Dioxide Phase Transition Control Prepared at Room Temperature
Authors: Liu Yixin , Gu Manna , Tian Ying , Liu Jianjun , Zhu Mingmin , Zhou Haomiao , Li Chenxia , Fang Bo , Hong Zhi , Jing Xufeng 
Published: January 2025

AbstractThe thermal phase transition characteristics of vanadium dioxide can effectively regulate the absorption performance of metamaterial absorbers. A petal‐shaped metamaterial absorber is designed based on vanadium dioxide phase transition control and prepared metamaterial samples using surface projection micro stereolithography (PµSL) 3D printing technology. Then, vanadium dioxide thin films are coated on the surface of the metamaterial using the ultrasonic spraying method. The PµSL 3D printing technology makes it possible to prepare high‐precision complex samples, and the ultrasonic spraying method enables the coating of vanadium dioxide thin films at room temperature. To demonstrate the stability of this method, two different metamaterial structures are prepared: planar structure and hemispherical structure. In the experiment, a non‐contact heating method is used to regulate the temperature of the vanadium dioxide thin film, which made the temperature of the metamaterial sample controllable, stable, and uniformly heated. The experimental results show that the designed metamaterial absorber has excellent modulation performance and excellent switching characteristics, which proves the reliability of the method.
Information Acquisition Under Providers' Competition
Authors: Zhai Youzi , Xue Weili , Chen Jing 
Published: January 2025

ABSTRACTThis paper studies the strategic interactions between two competing information providers and two competing downstream firms. We find that when one provider sets a moderate price and the other a higher price, the firm with more private information tends to acquire additional information to extend its advantage. Conversely, the firm with less private information forgoes further acquisitions, weakening competition. Moreover, symmetric providers have incentives to set asymmetric prices due to heterogeneous firms' inclination to differentiate information sources. Although the competition between providers may increase the firms' information acquisition costs, it can simultaneously mitigate heightened competition between firms.