bluuebunny/crossref_metadata_2025_split huggingface dataset:
HistoScanning<sup>TM</sup> vs. standard multifocal biopsy for prostate cancer diagnosis: a comparison of diagnostic methods
Authors: Kotov S. V. , Guspanov R. I. , Pulbere S. A. , Yusufov A. G. , Khachatryan A. L. , Badretdinov I. S. , Zhilov M. S. , Alekberov E. M. , Logvinova S. L. 
Published: December 2023

Introduction. Prostate cancer (PCa) is one of the most common malignant diseases. The prostate biopsy is the verification standard of PCa. The multifocal biopsy under ultrasound (US) guidance shows high rate of false negative results. As a result, the new diagnostic methods have been discovered. HistoscanningTM is the new method of visualization. HistoscanningTM is a new prostate tissue differentiation technology based on US backscatter analysis. The software analyses tissue density builds a 3D model of the prostate and indicates the localisation of PCa-suspect foci that are targeted for biopsy.Objective. To rate the diagnostic accuracy of HistoscanningTM and identify the benefits of targeted prostate biopsy compared to the multifocal biopsy.Matherials & methods. A prospective study conducted between Jan 2017 and May 2021 is presented. Ninety-hundred nine patients who underwent transrectal prostate biopsy in Pirogov City Clinical Hospital No. 1 were included. Control group A — 443 men after standard multifocal biopsy, comparison group B — 506 men after combined standard multifocal biopsy together with targeted biopsy using HistoscanningTM.Results. In the control group, prostate cancer was detected in 33.4% of patients, while in the group using the HistoscanningTM device it was found in 39.7%. ISUP 1 high-grade PCa were more frequent in group В — 71.1%, in group А— 52.7%. Isolated lesion of targeted biopsy specimens was found only in 9 patients (4.5%) of the group В. Combined lesion of standard and targeted biopsy specimens was more frequent and was detected in 121 patients. However, in 72 patients no atypical cells were detected in targeted biopsy specimens when prostate cancer was verified in standard biopsy specimens. The efficacy of HistoscanningTM was comparable to standard biopsy for prostate volumes > 60 cс.Conclusion. The use of HistoscanningTM improves the diagnosis of PCa, mainly due to the ISUP 1. Performing only targeted cores is impractical due to the high percentage of false negative results. Combined prostate biopsy with mandatory sampling of targeted biopsy cores along with standard biopsy specimens is indicated. The diagnostic accuracy of HistoscanningTM showed the best results with a prostate volume <60 cc.
Worldwide Distribution and Extracutaneous Manifestations of Henoch-Schönlein Purpura in Adults: Narrative Review
Authors: Harris Blair W , Maxfield Luke , Hunter Abigail , Alhajj Mandy , Ban Byung , Pulsipher Kayd J 
Published: December 2023

Background
Henoch-Schönlein purpura (HSP), a leukocytoclastic small vessel vasculitis, exhibits both cutaneous and systemic manifestations. While predominantly observed in childhood, it may manifest in adults with more pronounced systemic involvement. Furthermore, HSP is a global phenomenon showcasing epidemiological and systemic variances.

Objective
This study aims to scrutinize extracutaneous manifestations in adults with HSP, discerning distinctions according to geographical regions on a worldwide scale.

Methods
A comprehensive search encompassing PubMed, Embase, Cochrane Library, and Web of Science was executed, covering papers published from January 1, 1970, to December 1, 2019. Keywords used included “Henoch-Schönlein purpura,” “henoch schonlein purpura+adult,” “IgA vasculitis+adult,” “HSP+adult,” and “IgAV.” A total of 995 publications were identified, from which 42 studies encompassing 4064 patients were selected, with a predominant focus on cases reported in Asia, Europe, and the Americas.

Results
Among adults afflicted with HSP, European patients exhibited a higher propensity for male predominance (P<.001), gastrointestinal involvement (P<.001), and musculoskeletal complications (P<.001). Conversely, patients from the Americas were least likely to experience genitourinary involvement (P<.001).

Conclusions
HSP demonstrates a variance in distribution and extracutaneous manifestations within distinct geographical boundaries. In the adult population, European patients exhibited a higher prevalence of male gender and gastrointestinal and musculoskeletal involvement. Asian patients were more predisposed to genitourinary involvement when compared to their American counterparts. The establishment of prospective studies using standardized reporting measures is imperative to validate the relationships unveiled in this investigation.
Exploring the Feasibility of Using ChatGPT to Create Just-in-Time Adaptive Physical Activity mHealth Intervention Content: Case Study
Authors: Willms Amanda , Liu Sam 
Published: December 2023

Background
Achieving physical activity (PA) guidelines’ recommendation of 150 minutes of moderate-to-vigorous PA per week has been shown to reduce the risk of many chronic conditions. Despite the overwhelming evidence in this field, PA levels remain low globally. By creating engaging mobile health (mHealth) interventions through strategies such as just-in-time adaptive interventions (JITAIs) that are tailored to an individual’s dynamic state, there is potential to increase PA levels. However, generating personalized content can take a long time due to various versions of content required for the personalization algorithms. ChatGPT presents an incredible opportunity to rapidly produce tailored content; however, there is a lack of studies exploring its feasibility.

Objective
This study aimed to (1) explore the feasibility of using ChatGPT to create content for a PA JITAI mobile app and (2) describe lessons learned and future recommendations for using ChatGPT in the development of mHealth JITAI content.

Methods
During phase 1, we used Pathverse, a no-code app builder, and ChatGPT to develop a JITAI app to help parents support their child’s PA levels. The intervention was developed based on the Multi-Process Action Control (M-PAC) framework, and the necessary behavior change techniques targeting the M-PAC constructs were implemented in the app design to help parents support their child’s PA. The acceptability of using ChatGPT for this purpose was discussed to determine its feasibility. In phase 2, we summarized the lessons we learned during the JITAI content development process using ChatGPT and generated recommendations to inform future similar use cases.

Results
In phase 1, by using specific prompts, we efficiently generated content for 13 lessons relating to increasing parental support for their child’s PA following the M-PAC framework. It was determined that using ChatGPT for this case study to develop PA content for a JITAI was acceptable. In phase 2, we summarized our recommendations into the following six steps when using ChatGPT to create content for mHealth behavior interventions: (1) determine target behavior, (2) ground the intervention in behavior change theory, (3) design the intervention structure, (4) input intervention structure and behavior change constructs into ChatGPT, (5) revise the ChatGPT response, and (6) customize the response to be used in the intervention.

Conclusions
ChatGPT offers a remarkable opportunity for rapid content creation in the context of an mHealth JITAI. Although our case study demonstrated that ChatGPT was acceptable, it is essential to approach its use, along with other language models, with caution. Before delivering content to population groups, expert review is crucial to ensure accuracy and relevancy. Future research and application of these guidelines are imperative as we deepen our understanding of ChatGPT and its interactions with human input.
SOUND IMPROVISATION THROUGH IMAGE AND SHAPE
Authors: Zećo Mirsada , Videnović Marina , Žmukić Maja 
Published: December 2023

The authors were engaged in creating activities for workshops in which sound improvisation was combined with artistic expression and introduced to a student-level classroom. The aim of this research is two-fold. The first aim was to examine how students experienced this type of work through workshops. The second was the analysis of students’ drawings following the sound improvisation performance. The workshops were attended by 135 students, aged 19 to 24, from three different faculties. The main research question was if art content can, through sound improvisation and image, significantly awaken positive emotions in students by means of two different mediums. Internalising and developing a positive self-image in students show that there is a correlation between the content of music and art, as well as their influence on the intensity of aesthetic experience. The results showed that the students felt relaxed during the workshop and that they were willing to once again participate in a similar activity. Additionally, the drawings they produced during the workshop were analysed. As a conclusion, it is desirable to integrate content in music and art classes as its aim is to intensify experience, process of development and creation of a safe and positive learning environment. This explorative research showed that it is essential to work on developing experiences of social and emotional content through sound and image, as well as mutual connection strategies of learning and emotionally-aesthetic expression. Key words: sound improvisation, drawing, artistic speech, intensity of feelings
Influence of Genetics Polymorphism of OATP2B1Transporter on Montelukast Response in Samples of Asthmatic Children
Authors: Haider Mohammed Hasnaa , Abdul-Reda Uday , Mahmood  Abo-Almaali Hassan , Mahdi Hussien Akeel 
Published: December 2023

Objectives:
The primary objectives are to evaluate the impact of OATP2B1c.935G>A (rs12422149) genetic polymorphisms on montelukast treatment responses in children with asthma in Iraq.
Methods and patients:
This observational cross_sectional study was conducted from the beginning of October 2022 up to the ending of September 2023 at the respiratory clinic centre of the Karbalaa Hospital for Children.One hundred participants, both male and female, aged between six and fifteen, who had been taking montelukast as a control medication on a daily basis for at least a month, were included in the study.Following DNA extraction, allele_specific PCR was performed to identify the genotypes of the various patients. Measurements of total serum IgE, the Asthma Control Test(ACT), and the Pulmonary Function Tests (PEF and FEV1) were made.
Results: Genetic amplification results indicate that the distribution of the polymorphism of the c.935G>A gene was 48% in GG wild homozygous, 45% in GA mutant heterozygous, and 7% in mutant homozygous AA.
Patients with mutant genes (GA and AA) exhibit high total IgE, low PEF and FEV1, and <19 ACT scores. This polymorphism is expected to have a significant association (p value<0.05)withmontelukast responsiveness.
Conclusions:
A significant association, was seen between the montelukast response and the OATP2B1 c.935 G>A genetic polymorphism.
Prevalence of Torque Teno Virus (TTV) in Blood Donor from Baghdad-Iraq
Authors: Haidar Salman Maha , Mujahid Al-Shuwaikh Arwa 
Published: December 2023

Background: In 1997, Torque Teno virus (TTV) discovered for the first time in Japanese patients who suffer from hepatitis. Then, it is detected in healthy individuals without causing harmful effects. Also, it is a part of our microbiome, with a high rate in all populations. This virus belong to a large viral family called Anelloviridae. Today, there are many suggestions to use TTV as a novel biomarker for medical and environmental purposes.
Objective: To determine the rate of TTV infection in Iraqi blood donors. And evaluate any association with demographic and risk factors.
Methods: This cross-sectional study conducted on serum samples from 359 participants who attended the blood donation unit of Al-Imammain Al-Kadhimain Medical City Hospital and National Blood Transfusion Center in Baghdad. The study sample consists of 351 males and only 8 females; their mean age is (36.04 ± 9.35 SD). For a period from November 2022 to January 2023. A nested polymerase chain reaction (PCR) was used to detect TTV untranslated region.
Results: The TTV virus was detected in 93.9% (337 out of 359) of blood donors. However, no significant association was found between demographic data (sex, age) and risk factors such as history of (medical surgery, tattooing, cupping practice, marital status, multiple sexual partners, animal husbandry , travel history), under line medical condition (diabetes mellitus and hypertension), viral hepatitis co-infection and occupation with TTV infection rate.
Conclusion: This study showed a high prevalence of TTV among healthy blood donors with no significant association with demographic data and risk factors. These results support that TTV as a part of the human virobiome and normally found in the majority of populations.
Sea Ice and Ocean Response to a Strong Mid-Winter Cyclone in the Arctic Ocean
Authors: Watkins Daniel Mark , Persson Ola P G , Hutchings Jennifer K , Stanton Timothy P , Solomon Amy 
Published: December 2023

Sea ice mediates the exchange of momentum, heat, and moisture
between the atmosphere and the ocean. Cyclones produce strong gradients
in the wind field, imparting stress into the ice and causing the ice to
deform. In turn, increased sea ice drift speeds and rapid changes in
drift direction during the passage of a cyclone may result in enhanced
momentum flux into the upper ocean. During the year-long MOSAiC
expedition, an array of drifting buoys was deployed surrounding the R/V
Polarstern, enabling the characterization of sea ice motion and
deformation across a range of spatial scales. In addition, autonomous
sensors at a subset of sites measured the atmospheric and oceanic
structure and vertical fluxes. Here, we examine a strong cyclone that
impacted the MOSAiC site during January and February, 2020, while the
MOSAiC site was near the North Pole.

The cyclone track intersected the MOSAiC buoy array, providing
an opportunity to examine spatial variability in sea ice motion during
the storm in unprecedented detail. A key feature of the storm was the
formation of a low-level jet (LLJ), first in the warm sector of the
storm, then growing to eventually encircle the central low. The highest
rates of ice motion and deformation coincide with effects of LLJ
transitions. Analysis of deformation using the Green’s theorem approach
indicates divergence and cyclonic vorticity as the LLJ enters the
region, and convergence and anticyclonic vorticity as the LLJ leaves;
maximum shear strain rate is enhanced throughout the LLJ’s passage.
While the vorticity signal is particularly clear, floe structure and
internal ice stresses result in high spatial variability in the
magnitude of divergence and shear strain rates, especially at smaller
scales. Increased current speed and shear in the upper layer of the
ocean during the passage of the LLJ resulted from ice drag forcing the
ocean mixed layer current. The results suggest an important role for
cyclone-forced ocean mixing in pack ice during the Arctic winter.
Model Pembelajaran Talking Stick Berbantuan Media Audio Visual Terhadap Kompetensi Pengetahuan IPS Siswa Kelas V SD
Authors: Ni Putu Leny Purwani  , Ni Wayan Suniasih  
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Model Pembelajaran Talking Stick Berbantuan media audio visual terhadap kompetensi pengetahuan IPS siswa kelas V SD Negeri Gugus Pattimura tahun ajaran 2022/2023. Jenis penelitian ini adalah penelitian eksperimen semu (quasy experiment) dengan rancangan penelitian non-equivalent control group design. Populasi penelitian ini adalah seluruh kelas V SD Negeri Gugus Pattimura Tahun Ajaran 2022/2023 banyak siswa 310 orang. Sampel dalam penelitian ini 31 siswa kelas V dari SD Negeri 7 Sesetan menjadi kelompok eksperimen dan 32 siswa kelas V dari SD Negeri 3 Sesetan menjadi kelompok kontrol dan seluruhnya sebanyak 63 orang siswa. Penentuan sampel dalam penelitian ini menggunakan teknik cluster random sampling. Data kompetensi pengetahuan IPS siswa dikumpulkan dengan menggunakan metode tes bentuk pilihan ganda biasa yang kemudian dianalisis menggunakan uji-t. Hasil analisis data diperoleh thitung = 2,817 sedangkan pada taraf signifikan 5% dan dk= 61 diperoleh nilai ttabel=2,000 sehingga thitung = 2,817> ttabel=2,000 maka, Ho ditolak dan Ha diterima yang berarti terdapat perbedaan kompetensi pengetahuan IPS siswa yang dibelajarkan menggunakan model pembelajaran Talking Stick berbantuan media audio visual dengan kompetensi pengetahuan IPS siswa yang tidak dibelajarkan dengan model pembelajaran Talking Stick berbantuan media audio visual pada siswa kelas V SD Negeri Gugus Pattimura tahun ajaran 2022/2023. Hasil penelitian menunjukkan rata-rata kelompok eksperimen lebih tinggi daripada nilai rata-rata kelompok kontrol (82,081 > 77,375). Dengan demikian, Talking Stick berbantuan media audio visual berpengaruh terhadap kompetensi pengetahuan IPS siswa kelas V SD Negeri Gugus Pattimura tahun ajaran 2022/2023
Theoretical Model of an Experiment to Test the Isotropy of the Speed of Light
Authors: Midasala Alex 
Published: December 2023

The value for the speed of light ‘c’ = 299792458 m/s is widely known and used in theoretical physics, experimental physics, astronomy and astrophysics. However, this is the roundtrip speed from the source to the detector and back. The roundtrip speed of light has been verified thoroughly by several experiments to be a constant. Still, the equality of the one-way speed of light with the roundtrip speed of light, or the isotropy of the one-way speed of light, has never been verified. It is impossible to measure the one-way speed of light unless an absolute (standard) simultaneity is to be found. Yet, testing the isotropy of the one-way speed of light using a mathematical structure that resembles an isosceles triangle is still possible. Since the roundtrip speed of light has already proven to be isotropic, there are values only with which the one-way speed of light can travel in a path, maintaining the roundtrip speed of light to be isotropic. These values serve as limits to the maximum speed that the one-way speed of light can have in its direction of propagation in its path, from which two light pulses from both ends of its path send to the same clock, thereby evading the need for synchronization and allowing the possibility to test the constancy of the one-way speed of light.
VILLAGE FINANCIAL MANAGEMENT IN GAMPONG BLANG MAKMUR KUALA BATEE DISTRICT SOUTHWEST ACEH REGENCY
Authors: Syarkawi Syarkawi , Koeswara Hendri , Aromatica Desna 
Published: December 2023

The birth of Law Number 6 of 2014 concerning Villages became a milestone in changing the paradigm about villages. The village is no longer an object but has become a subject of development and has the authority to manage its own finances. As a consequence of this authority, financing or finance is a very essential factor in supporting the implementation of village autonomy or gampong. The handover of authority to gampong raises great demands on financial management by the community against the Gampong Government. These demands must be responded to by making changes in gampong financial management. This study aims to determine how financial management in Gampong Blang Makmur, Kuala Batee District, based on Permendagri Number 20 of 2018 concerning Village Financial Management. With the research method carried out using a type of descriptive qualitative research that seeks to tell the solution of problems that occur now based on data in which there are efforts to describe, record, analyze and interpret conditions that are now occurring in other words descriptive research aims to obtain information about the current situation with data collection techniques in the form of interviews, ducumentation and observation. Gampong Blang Makmur's financial management has been carried out properly in accordance with the stages and principles in village financial management in accordance with the mandate of Permendagri Number 20 of 2018 concerning Village Financial Management. However, there are several shortcomings and weaknesses in the implementation at each stage, including: The determination of the Gampong Blang Makmur APBG is not in accordance with the established schedule; Inadequate apparatus human resources in gampong financial management, to delayed and untimely gampong financial management accountability reports. On the other hand, gampong financial management is not as autonomous as imagined, most of gampong's finances are guided to implement district priority programs.
CASES OF VIOLENCE AGAINST WOMEN HANDLED BY SENTRA PARAMITA MATARAM
Authors: Aswili Lalu Wahyu Harits , Malihah Elly , Nurbayani Siti 
Published: December 2023

Various forms of societal violence often target women, causing significant impacts on well-being and requiring substantial recovery efforts. This research aims to comprehensively explain the different forms of violence against women in Sentra Paramita Mataram. The study employs a descriptive method with a qualitative approach, enabling an in-depth exploration of experiences and perceptions of victims and a better understanding of the context of the violence. Primary subjects are women who have been victims of violence in Sentra Paramita Mataram, with social workers, psychologists, and nurses as informants. This approach allows for a thorough examination of the experiences and perceptions of victims, providing a nuanced understanding of the dynamics of violence against women in this specific setting. Data collection methods include in-depth interviews, observations, and documentation. The data analysis process involves presenting data, reducing data, verifying information, and drawing conclusions. Study findings reveal that the most prevalent form of violence against women in Sentra Paramita Mataram is physical violence, including actions such as causing injuries, physical assaults, torture, and rape. Non-physical incidents of violence against women, such as verbal abuse, harassment, involvement in commercial sex work, and neglect, also receive attention. Both physically and non-physically experienced violence compels victims to seek immediate assistance at Sentra Paramita Mataram, underscoring the urgent role of the center as a support and protection hub for victims. This research contributes to a profound understanding of the dynamics of violence against women in this environment and lays the groundwork for more effective intervention and prevention measures.
Dark Side of Institutional Entrepreneurship in Latin America: Vistas from Reflexivity
Authors: Méndez Oscar Javier Montiel , García Rosa Azalea Canales , Novelo Anel Flores 
Published: December 2023

AbstractEntrepreneurial development in Latin America is varied and complex. The concept of reflexivity can be used to investigate the complexities of the entrepreneurial system in Latin America; however, it has rarely been used in entrepreneurship, which refers to finding strategies to question our attitudes, thought processes, values, assumptions, prejudices, habitual actions, and understanding how we relate to others. To explore reflexivity and how this area can provide support to reimagine Latin American entrepreneurial dynamics, a literature review was conducted, and two theoretical models were proposed that show the complexity of the region and routes where reflexivity can foster a path for the region to change and advance its entrepreneurial efforts.