bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of a Multimodal Rehabilitation programme in bariatric surgery versus the classic care protocol
Authors: Ortega-Lucea Sonia María , Herrero-Martín Laura , Pascual-Bellosta Ana María , Casamayor-Franco M. Carmen , Palomares-Cano Ana , Aragón-Benedí Cristian , Guallar-García David , Ramirez-Rodriguez Jose Manuel , Satústegui-Dordá Pedro José , Martinez-Ubieto Javier 
Published: January 2024

Abstract

Introduction: Obesity is a very frequent pathology in our society. Weight gain and its associated comorbidities constitute a major cause of preventable deaths. Bariatric surgery is considered the most effective treatment for reducing weight and comorbidities in obese patients. ERAS (Enhanced Recovery After Surgery) programmes are a set of perioperative practices aimed at reducing the metabolic and immune response triggered by surgical stress, to improve the results of the intervention and achieve a speedy recovery of the patient. Their implementation in bariatric surgery has been slow, since obese patients constitute a high-risk surgical group.
Objective: To determine whether the application of an ERAS protocol in bariatric surgery leads to a reduction in hospital stay, as well as in the complications associated with the procedure.
Material and methods: A prospective case-control study was performed including 52 patients undergoing bariatric surgery: 25 following the classic protocol and 27 following the ERAS protocol. Results were analysed using the bilateral hypothesis. Statistical significance of the difference was considered from p-values less than 0.05. Confidence intervals included were 95%.
Results: There was a reduction in hospital stay (- 0.76 days, p=0.002579), minor complications (48% less), postoperative nausea and vomiting rate (p=0.00029) and postoperative pain (p=1.36e-05) in those patients who followed the ERAS protocol.
Conclusions: The implementation of the ERAS protocol reduces hospital stay, without compromising patient safety by not increasing morbidity.
The Effect of PAP Produced by Back Squats with Different Squat Methods on the Ability of Squat Jump
Authors: Hengyuan Liu , Sinclair Jonathan K. , Te Bu , Zhi Ming , Chenchen Sun , Grecic David , Changfa Tang 
Published: January 2024

Abstract

The aim of this study was to investigate the effects of PAP induced by different squat amplitudes on squat jump and the interaction between squat amplitude, stimulus load (%1RM) and PAP duration, and to establish an exercise intervention programme.
Method: Fifteen track and field athletes aged 20-22 years were selected to perform barbell back squats at knee angles of 60°, 90° and 120° and loads of 75% 1RM, 85% 1RM and 95% 1RM, and their flat squat heights were tested at the 3rd, 6th, 9th and 12th minute after each combination of barbell back squats.
Results: (1) The 120° knee angle-95%1RM combination produced the best squat jump performance after stimulation (42.47±5.26cm), combinations close to this result include the 120° knee angle-85%1RM (42.27±4.70cm) and the 90° knee angle-95%1RM (42.40±5. 50cm); (2) when load and interval were the same, the effect of different knee angles on squat performance was 120 knee angle > 90 knee angle > 60 knee angle, and when knee angle and interval were the same, the effect of different loads of 1RM on squat performance was 95%1RM>85%1RM>75%1RM, with a high probability of peak occurring at the 9th minute after stimulation.
Conclusion: Athletes participating in lower limb explosive power events such as the high jump and long jump should perform a PAP induction with a back squat at a knee angle of 90°-120° and 85-95% of 1RM weight 6-12 minutes prior to competition.
Nursing faculty experiences with emergent remote teaching transitions during the COVID-19 pandemic: A qualitative systematic review
Authors: Joo Jee Young , Kim Kyoung-A 
Published: January 2024

Abstract

Background
The coronavirus disease 2019 (COVID 19) pandemic led to lockdowns and other social distancing measure. Nursing education programs were also disrupted and moved online. However, information and understanding of nursing faculty members’ experiences of the emergent transition from didactic to remote teaching during the COVID-19 pandemic is limited. Therefore, this qualitative systematic review aimed to synthesize qualitative studies on nursing faculty members’ experiences during the COVID-19 pandemic in the United States.
Methods
Eight qualitative studies published between January 2020 and the end of December 2023 in the United States were selected from five electronic databases and synthesized based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and Thomas and Harden thematic synthesis methods. This study was reviewed and registered in PROSPERO.
Results
Eight primary and empirical qualitative studies published between 2021 and 2023 were included. The included studies were conducted in various regions of the United States and involved nursing faculty members working in nursing programs. Based on the experiences of 230 nursing faculty members, five common themes were identified: (1) concerns about changes in traditional nursing pedagogy, (2) overwhelmingly heavy workloads, (3) acceptance of and coping with the pandemic, (4) the need for continuous and various forms of support, and (5) opportunities for the improvement of nursing programs.
Conclusions
These themes can be utilized by educational administrators to reidentify the challenges that nursing faculty face and to reform nursing education programs as well as nursing educational associations and institutes to improve current teaching and direct new learning methods to prepare for future pandemics.
WITHDRAWN: Effects of enzyme preparation and straw expansion treatment on sorghum micro-storage performance and microbial community
Authors: Sun Yuxin , Liu Mingjian , Bai Baochao , Sheng Panjie , An Jiangbo , Bao Ruiying , Yuan Zitong , Liu Tingyu , Shi Kai 
Published: January 2024

Abstract

Background Sorghum is commonly used as feed in livestock farming. However, due to its high lignin and cellulose content, sorghum straw is not highly digestible for animals. To improve the feeding value of sorghum straw, researchers have explored micro-storage techniques. Enzyme preparation and straw expansion treatment are two commonly used methods, but their effects on sorghum micro-storage performance require further investigation.Results Sorghum exhibits relatively low nutritional value, but the addition of enzyme preparation and puffing treatment can enhance its value. These methods facilitate the breakdown of plant cell walls, releasing more nutrients and fermentable sugars, thus improving the digestibility and nutritional value of ensiled feed. Cellulase and xylanase can degrade cellulose and hemicellulose, respectively, which serve as important carbon sources for alkaligenic bacteria growth. Straw expansion treatment alters the proportions of lignin, cellulose, and hemicellulose in sorghum straw, leading to partial lignin degradation and an increase in organic matter content. The presence of lactic acid bacteria and alkaligenic bacteria enhances carbohydrate metabolism, amino acid, coenzyme, and vitamin metabolism, as well as signal transduction pathways, thereby improving microbial community structure, metabolism, and fermentation quality of ensiled sorghum feed. This study found that combined xylanase addition after expansion treatment significantly improves the micro-storage performance of sorghum straw. These findings provide a theoretical basis for optimizing sorghum straw micro-storage techniques to enhance its feeding value and animal production performance.Conclusions This study demonstrated that the addition of enzyme preparation significantly improved the quality of ensiled sorghum straw, with the best results achieved through the addition of xylanase. The sequential application of expansion treatment and enzyme addition yielded the best micro-storage performance for sorghum straw. These findings provide a theoretical basis for optimizing sorghum straw micro-storage techniques, contributing to increased feeding value and animal production performance. This study revealed, for the first time, the underlying principles of the synergistic effect between enzyme preparation and straw expansion treatment in the sorghum ensiling system, which provided valuable insights for the development and utilization of sorghum feed resources, and promotion of sustainable livestock production.
Tool wear monitoring for robotic milling based on multi-dimensional stacked sparse autoencoders and bidirectional LSTM networks with singularity features
Authors: Zhou Chang'an , Zhang Kaixing , Guo Kai , Liu Xin , Hu Bingyin , Wang Gang 
Published: January 2024

Abstract

This study addresses the challenges posed by the vibration-induced wear and breakage of milling cutters during the machining large parts using industrial robots with six degrees of freedom. The proposed tool wear monitoring method (TWM) relies on a sophisticated framework that integrates a multi-dimensional stacked sparse autoencoders (MD-SSAEs) network and bidirectional long short-term memory networks (BiLSTM) incorporating singularity features. The method begins with a singularity analysis (SA) approach, which is employed to extract local features and eliminate the impact of irregular fluctuations. Following this, MD-SSAEs are strategically designed to conduct dimension reduction of SA features and facilitate the deep fusion of multiple features. Subsequently, BiLSTM is employed to map the deep-fused features and model the relationship between continuous tool wear progression. Finally, two milling experiments with full wear cycle were carried out on a self-made robot milling platform to verify the effectiveness of the proposed method. The experimental results affirm that the established method demonstrates exceptional prediction accuracy and robust adaptability to variations in cutting parameters. Leveraging this approach, a TWM system is developed, providing an effective tool replacement guide for real-world manufacturing scenarios.
Transcriptome of plasma exosome identifies a hsa-miR-483-5p/mRNAs network that regulates chemotherapy resistance in locally advanced rectal cancer
Authors: Li Ganbin , Shi Weikun , Li Lifeng , Zhang Xiao , Qiu Xiaoyuan , Chen Weijie , Zhou Jiaolin , Lin Guole 
Published: January 2024

Abstract
Chemoresistance is a primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, the underlying mechanisms remain elusive. In this study, the profiles of plasma exosome miRNAs were compared in two dimensions according to treatment responses (poor/well-responders) and treatment courses (pre/post-nCRT) by RNA-sequencing. The exosome hsa-miR-483-5p was up-regulated in well-responders post-nCRT. The bioinformatic analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways, like MAPK signaling pathway, EGFR tyrosine kinase inhibitor resistance, Toll-like receptor signaling pathway, VEGF signaling pathway, and mTOR signaling pathway. A further analysis indicated that the genes MAPK3, RAX2, RNF165 were associated with inferior recurrence-free survival in rectal cancer patients, and the profiles of MAPK3, TSPYL5, ZNF417 were correlated with tumor stages. In addition, the expression profiles of MAPK3, RNF165, ZNF417 were negatively correlated with inhibitory concentration 50 values. Accordingly, a network of hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 were constructed. The study provides insights into the mechanism of chemoresistance in terms of exosome miRNAs, but further research is needed within the framework of our established miRNA-mRNA network.
Lower bounds for the Randiæ energy of graphs
Authors: Jahanbani Akbar 
Published: January 2024

Abstract

The Randiæ energy of a graph G, denoted by RE(G), is defined as the sum of the absolutevalues of all eigenvalues of Randiæ matrix. In this paper, we will obtain some new lowerbounds for the Randiæ energy and improve some previous well-known bounds.
AMS subject classification: 05C50
Biomimetic Polydopamine Loaded with Janus Kinase Inhibitor for Synergistic Vitiligo Therapy via Hydrogel Microneedles
Authors: Li Chunying , Wang Wenwen , Zhou Sen , Shao Junyi , Ji Xiaolin , Xi Youxia , Xu Qiuyang , Huang Yuhan , Wan Yilin , Li Zhiming , Wang Jingle 
Published: January 2024

Abstract

Background
Both oxidative stress and autoimmune responses play crucial roles in the development of vitiligo. Under oxidative stress, the apoptotic melanocytes exposure self-antigens and release high mobility group box 1 (HMGB1), triggering autoimmune activation and recruiting CD8+ T cells. This process further leads to the destruction of melanocytes, resulting in a lack of melanin granules. Additionally, oxidative stress induces keratinocytes to express and release T cell chemotactic factors, exacerbating vitiligo. The reduction of CD8+ T cells by safeguarding melanocytes and keratinocytes from oxidative stress may be contemplated as a promising approach for vitiligo therapy.
Results
In this study, we introduce a novel therapeutic agent called PDA-JAKi, which is capable of both eliminating oxidative stress and inhibiting T cell activation. Specifically, we have incorporated the janus kinase inhibitor (JAKi) tofacitinib into antioxidant polydopamine (PDA) nanoparticles, resulting in the formation of uniform PDA-JAKi nanodrug. PDA effectively mitigates apoptosis in melanocytes, reducing the antigen presentation and release of HMGB1. Simultaneously, PDA alleviates oxidative stress in keratinocytes, leading to a reduction in the expression of chemotactic factors. JAKi, binding to JAK, significantly diminishes the activation of T cells. We precisely deliver this therapeutic agent to the dermis using microneedle (MN) patches, aiming to enhance therapeutic efficacy compared to traditional drug administration methods. After PDA-JAKi MN treatment, the symptoms of vitiligo in mice are alleviated, and the affected areas regain pigmentation. Enhancements have been noted in the dermal thickness within the treated skin area. Concurrently, a decrease in the abundance of immune cells, particularly the infiltration of CD8+ T cells, have been observed. Moreover, there is a notable reduction in interferon-γ (IFN-γ) levels, along with a substantial decrease in the chemotactic factors C-X-C motif chemokine ligand 10 (CXCL10) and C-X-C motif chemokine ligand 16 (CXCL16).
Conclusions
In summary, PDA-JAKi MN nanoplatform emerges as a promising therapeutic agent in vitiligo treatment.
H2-Quartz and Cushion Gas-Quartz Intermolecular Interactions: Implications for Hydrogen Geo-Storage in Sandstone Reservoirs
Authors: Sikiru Surajudeen , Al-Yaseri Ahmed , Yekeen Nurudeen , Soleimani Hassan , N Bonnia N. , Hamza Mohammed Falalu , Ghotbi Mohammad Yeganeh 
Published: January 2024

Abstract
Emissions of carbon dioxide (CO2) from fossil fuel usage continue to be an incredibly challenging problem to the attainment of CO2 free global economy; carbon Capture and Storage (CCS) and the substitution of fossil fuel with clean hydrogen have been identified as significant primary techniques of achieving net zero carbon emissions. However, predicting the number of gas trapped in the geological storage media effectively and safely is essential in attaining decarbonisation objectives and the hydrogen economy. Successful underground storage of carbon dioxide and hydrogen depends on the wettability of the storage/cap rocks as well as the interfacial interaction between subsurface rocks, the injected gas, and the formation of brine. A key challenge in determining these factors through experimental studies is the presence of conflicting contact angle data and the difficulty of accurately replicating subsurface conditions in the laboratory. To address this issue, molecular dynamics simulations offer a microscopic approach to recreating subsurface conditions and resolving experimentally inconsistent results. Herein, we report the molecular dynamics simulation results for hydrogen (H2) and cushion gas ( e.g., CO2 and N2) on quartz surfaces to understand the capillary and trapping of these gases in sandstone formations. The results of these three gasses were compared to one another. The simulation predictions showed that the intermolecular interactions at the CO2-quartz surface area are more substantial than at the N2 and H2-quartz interface, suggesting that the quartz surface is more CO2-wet than N2 and H2-wet under the same circumstances. In addition, it was found that CO2 has a substantially higher adsorption rate (~ 65 Kcal/mol) than N2 (~ 5 Kcal/mol) and H2 (~ 0.5 Kcal/mol). This phenomenon can be explained by the fact that CO2 density is substantially larger than N2/H2 density at the same geo-storage conditions. As a result, CO2 could be the most favorable cushion gas during underground hydrogen storage (UHS) because a higher CO2 residual is expected compared to H2. However, due to the Van der Waal Interaction force with quartz, only a small amount of H2 can be withdrawn.
Generalized Additive Models versus Geographically Weighted Regression: a comparative analysis
Authors: Alvarez Francisco de Asis Lopez , Ordoñez Celestino , Pardiñas Javier Roca 
Published: January 2024

Abstract

Regression models for spatial data have attracted the attention of researchers from different fields given their widespread application. In this work we analyze the utility of generalized additive models (GAMs) as a regression method with spatially-dependent coefficients and compare them with geographically weighted regression (GWR), a popular method that performs a local linear regression in the vicinity of each point. The comparison was carried out using both simulated and real data. The comparison results on the simulated data showed better fit and lower uncertainty in the GAM approximation. The comparison using real data showed quite similar results for both methods, although the error in GAM was slightly lower for the GAM approach. Two other important aspects of spatial regression were also tackled in this study: 1) testing the spatial heterogeneity of the data, 2) selecting the significant covariates. The first aspect was addressed using both bootstrapping and the Bayesian information criterion (BIC), while only BIC was used for the second aspect.
Design and analysis PSO based Fuzzy PID controller for Load frequency and voltage of the synchronous generator
Authors: Lemma Bisrat Gezahegn , Abebe Yidnekachew 
Published: January 2024

Abstract

The paper presents Automatic Voltage Regulator (AVR) and Automatic Generation Control (AGC) systems to manage real and reactive power and maintain a system's steady state. A change in system load affects its voltage and frequency. Due to unseen load changes, it is challenging to manage load frequency and voltage to keep them within the allowed limit. A control action must be required for automatic generation control to manage the load frequency and voltage. The Automatic generation control balances system generation with load and losses. The load frequency control (LFC) maintains the voltage profile, managing the active power flows inside the appliance, while the automatic voltage regulator keeps the bus bar voltage within acceptable limits by maintaining the synchronous generator's terminal voltage. An Integral Absolute Error (IAE) is taken as an objective function. PSO optimizes the Fuzzy-PID controller's gain and performance. The evaluation of frequency deviation and voltage fluctuation with time is carried out for single-area systems using the MATLAB 2021a program. The deviation of frequency response and voltage is reduced using the Fuzzy-PID controller, which is based on particle swarm optimization. PID-based traditional controller and a fuzzy-PID controller are compared. The PSO-based Fuzzy-PID controller proved more effective than the traditional control. The Integral Absolute Error (IAE) value for PID is 1.553 whereas the Integral Absolute Error (IAE) value for the PSO-based Fuzzy-PID is 0.6793. Therefore, the result shows that PSO-based Fuzzy-PID performs better than a PID controller.
Analysis of time delays in imported malaria diagnosis: not only on the patient’s shoulders.
Authors: Castillo-Fernández Nerea , Soriano-Pérez Manuel Jesús , Lozano-Serrano Ana Belén , Vázquez-Villegas José , Luzón-García María Pilar , Cabeza-Barrera María Isabel , Ocaña-Losada Cristina , Pérez-Moyano Rosario , Salas-Coronas Joaquín 
Published: January 2024

Abstract

Purpose
To analyze the diagnostic delay in malaria related to misdiagnosis at first visit medical visit and its association with the risk of severe malaria in non-endemic areas.
Methods
Retrospective observational study of sub-Saharan migrants with imported malaria from January-2010 to December-2022. Patients were allocated in two groups if they were tested for malaria at first medical visit or not. Time delays in seeking healthcare, medical diagnostic delay and total diagnostic delay were calculated.
Results
297 patients were included in the analysis. At first medical visit, malaria was misdiagnosed in 137 patients (46.1%). Medical diagnostic delay and total diagnostic delay were larger for the misdiagnosis group than for those properly diagnosed at first visit (p < 0.001). Although time in seeking healthcare was shorter in the misdiagnosis group, the presence of suggesting symptoms, such as fever, was lower (p < 0.050). Misdiagnosis was more frequent in emergency rooms linked to primary healthcare (p < 0.001). For the overall population (n = 297), total diagnostic delay was mainly due to delay in seeking healthcare. Initial misdiagnosis was associated with a higher risk of severe malaria (adjusted OR 2.23 [1.09–5.10], p = 0.031).
Conclusion
In a non-endemic area with a high rate of imported malaria, the percentage of patients misdiagnosed is surprisingly high. Misdiagnosis is associated with longer medical and total diagnostic delays and with a higher risk of severe malaria. It seems necessary to redesign training programs to improve knowledge among healthcare professionals and actions targeted to travelers to promote seeking healthcare advice promptly.
Ruthenium-106 Brachytherapy and Central Uveal Melanoma
Authors: Grajewski Luise , Kneifel Christiane , Wösle Markus , Ciernik Ilja F. , Krause Lothar 
Published: January 2024

Abstract
Purpose
Uveal melanoma (UM) is the most common primary ocular malignancy. The size of the tumor and its location are decisive for brachytherapy with β-emitting Ruthenium-106 (Ru-106) plaque. The treatment of juxtapapillary and juxtafoveolar UM may be challenging due to the proximity or involvement of the macula and optic nerve. High recurrence rates have been observed.
Methods
Central UM was defined as a lesion up to 5mm off the optic disc or fovea- radius of 5mm. Between January 2011 and July 2020, we treated 56 patients with Ru-106-brachytherapy. The clinical outcome for recurrence, visual acuity, and radiation-related toxicity was assessed. The follow-up was 66 (6-136) months.
Results
Of the 56 patients (56 eyes), eight patients (14%) suffered from local recurrence. Six relapsing UM of 19 patients (32%) were located close to the optic disc, and two patients had UM close to the macula (2/37, 5%), (p > 0,05). The overall rate of eye preservation was 89%. Visual acuity (VA) before treatments was 0,45 and was reduced to 0,26 after brachytherapy. Radiation retinopathy or opticopathy was detected in seven patients (13%), and radiation maculopathy in ten patients (17,9%). Six patients (11%) underwent enucleation due to recurrence or radiation-induced ophthalmopathy.
Conclusion
Therapy of central UM is challenging. We suggest, that central UM should be categorized as lesions laterally or medially to the fovea due to different likelihood of long-term control rates. Localization near the optic disc requires thoughtful management.