bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Legal Scopes of Liberty and the State in Light of the Utilitarianism of John Stuart Mill
Authors: Baramidze Luka 
Published: November 2023

In modern democracies the liberty of the individual is ensured and protected by the state or the government. But it is well-known that restrictions on liberty are institutionalized and the individual is responsible for obeying them. The liberty of the individual and its protection is provided through restrictions. On the other hand, the legal system and the government are the institutions that threaten the liberty of the individual. Mill’s thesis on individual liberty implies the primacy of it and sets out the social conditions in which it will be possible to realize and protect individual liberty. The main theme of his treatise On Liberty is the nature and boundaries of individual liberty, the scope of legitimate interference with individual liberty. In other words, the principle establishes a sufficient basis for the legitimate protection of the individual liberty, i.e. what is a restriction of a right, on the one hand, is at the same time a protection of it. An individual must be free from all forms of violence, if his/her actions do not harm others [Riley 2001, 46]. The purpose of the paper On Liberty is to provide one very simple principle. Main point of it is that the method of societies’ relations with the individual should not be coercion and control. No matter is it a case of physical violence as a form of punishment or as a form of moral coercion by society. Power over a member of a civilized community can only be exercised for the sole purpose of preventing harm to others. Thus, the liberty principle establishes a necessary condition for legitimate violence against any individual: his/her liberty of action must be restricted by law or opinion if there is a reasonable expectation that it will harm others.
Visual communicative practices in the context of the development of creative industries
Authors: Denysiyuk Zhanna 
Published: November 2023

The purpose of the article is to investigate visual communicative practices in the context of the development of creative industries and to reveal the interdependence of their development. The research methodology involves the use of a set of methods: analytical, synthetic, cultural, semantic, which will allow a comprehensive consideration of the given problem and obtain substantiated research results. The scientific novelty consists in the systematic generalization of the formation of modern communication based on the predominant visual factor and to reveal the interdependence with the trends of increasing the development of the sphere of creative industries, as well as the discovery of a characteristic semantic field as a factor in the retransmission of sign-symbolic cultural codes and corresponding messages. Conclusions. The technological capabilities of the modern information environment and visual communicative practices provide wide opportunities for the application and creation of visual images and meanings, not only representing objective reality, but also providing communicative needs, forming a separate space of the informational and communicative cultural environment capable of transmitting ideas, meanings and values cultures with a predominance of the visual component. Communicative strategies of creative industries are mostly oriented on visual perception, have their own symbolic and semantic load, are a way of understanding current events and phenomena of socio-cultural life and serve as a means of spreading relevant creative narratives and ideas.
Keywords: visual culture, visual communicative practices, creative industries, sign-symbolic field, informational and communicative environment, cultural codes, messages, intercultural exchange.
Renewable Energy Use in Green Hotels for Sustainability: A Systematic Review
Authors: Ghimire Bhawani  Thapa , Muneenam Umaporn , Techato Kuaanan 
Published: November 2023

This article studies the use of renewable energy in hotels as a means of promoting green practices and sustainability. The objective of the study is to previous research studies on renewable energy use in hotels and green practices. It is based on articles published in different journals between 2008 to 2023. Out of the initial 16500 articles screened by Google scholars and 1373 from Base, the matched topic was 200, after further screening 61 articles were selected for final review. Renewable energy use and green practices have been adopted by many hotels with sustainability practices. The study shows that many hotels have adopted renewable energy and green practices to promote sustainability. However, future research should focus on the relationship between the specific types of renewable energy used in hotels and their impact on green practices and sustainability.
IoT Botnet Detection Using Autoencoders and Decision Trees
Authors: Susanto Susanto , Arifin M. Agus Syamsul , Wijaya Harma Oktafia Lingga 
Published: November 2023

The use of IoT devices has grown rapidly, leading to an increase in cyber attacks that pose greater security and privacy threats than ever before. One such threat is botnet attacks on IoT devices. An IoT botnet is a group of Internet-connected IoT devices infected with malware and remotely controlled by an attacker. Machine learning techniques can be employed to detect botnet attacks. The use of machine learning-based detection methods has been shown to be effective in identifying cyber attacks. The performance of the detection system in machine learning can be improved by utilizing data reduction methods. The data reduction process in classification is used to overcome the problem of scalability and computation resources in the IoT. This paper proposes a detection system using the Autoencoder reduction method and the Decision tree classification method. The test results demonstrate that the Deep Autoencoder algorithm can reduce data and memory usage from 1.62 GB to 75.9 MB, while also improving the performance of decision tree classification, resulting in a high level of accuracy up to 100%. The Autoencoder approach in conjunction with the Decision Tree exhibits superior capabilities compared to previous studies.
FORMAÇÃO INICIAL DE PROFESSORES: RESGATE DA PRODUÇÃO ACADÊMICA BRASILEIRA (2017-2023)
Authors: Kanan Lilia Aparecida , Beppler Regimari Cristina Rodolfi , Silva Cinthia Lopes 
Published: November 2023

Este texto tem como objeto de estudo a formação inicial de professores e a práticas pedagógicas. O objetivo é analisar a produção acadêmica referente a formação docente e as práticas pedagógicas, do período compreendido entre 2017 e 2023, com foco na formação inicial de professores. Como procedimentos metodológicos foi realizada uma revisão de literatura sistematizada. Foram utilizadas as bases de dados Scielo, Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), Google Scholar, site da Universidade do Planalto Catarinense, Periódicos CAPES. Ao final do processo, foram selecionados 21 trabalhos. O levantamento de textos foi realizado a partir dos seguintes descritores: formação de professores, prática pedagógica, didática. Os principais resultados obtidos são: os estados do sul do Brasil (Santa Catarina e Paraná) e os anos de 2021 e 2023 concentram o maior número de publicações; os autores mais citados foram António Nóvoa e Selma Garrido Pimenta e a palavra-chave que mais se repetiu foi formação de professores. Em decorrência das análises qualitativas dos textos pode-se observar que a formação docente tem sido um processo contínuo e reflexivo, cujo resultado é a capacitação de professores para que possam enfrentar os desafios da atualidade em sua prática pedagógica.
Palavras-chave: Formação inicial de professores; Prática Pedagógica; Didática.

ABSTRACT
This research aims to study initial teacher training and pedagogical practices. The objective of the investigation is to analyze academic production regarding teacher training and pedagogical practices, from the period between 2017 and 2023, with a focus on initial teacher training. As methodological procedures, a systematic literature review was carried out. The databases Scielo, Brazilian Digital Library of Theses and Dissertations (BDTD), Google Scholar, website of the University of Planalto Catarinense, Periódicos CAPES were used. At the end of the process, 21 works were selected. The text survey was carried out using the following descriptors: teacher training, pedagogical practice, didactics. The main results obtained are: the southern states of Brazil (Santa Catarina and Paraná) and the years 2021 and 2023 concentrate the largest number of publications; the most cited authors were António Nóvoa and Selma Garrido Pimenta and the keyword that was most repeated was teacher training. As a result of qualitative analyzes it can be observed that teacher training has been a continuous and reflective process, the result of which is the training of teachers so that they can face nowadays challenges in their pedagogical practice.
Keywords: Initial teacher training; Pedagogical Practice; Didactics.
End-to-end Standardization of Original Medicines when Determining Related Impurities
Authors: Generalova Yu. E. , Terninko I. I. , Zelentsova A. B. 
Published: November 2023

Introduction. For tablets “Malоben, 60 mg” and “Etmaben, 300 mg”, permission was received to conduct phase I clinical trials, so they required a full cycle of research and standardization.Aim. Development of a unified analytical procedure for the determination of related impurities in samples (RS, API, FPP) of Malоben and Ethmaben.Materials and methods. RSs were obtained at the Department of Organic Chemistry of the St. Petersburg State Chemical and Pharmaceutical University; the synthesis of APIs and the production of FPP were carried out on an industrial scale in pharmaceutical production. The studies were carried out on a Flexar liquid chromatograph (PerkinElmer, USA), equipped with a pump (formation of a gradient on the low-pressure side), an autosampler, a column thermostat, a UV detector and a chromatographic column Intersil® ODS-3V, 5 µm, 100 Å, 250 × 4, 6 (Phenomenex, Japan).Results and discussion. In the research, uniform optimal chromatographic conditions were selected using the HPLC method to determine the RP in RS, API and FPP of Maloben and Ethmaben. Column C18 250×4.6 mm, mobile phase 0.1% phosphoric acid and acetonitrile (gradient elution), flow rate 1 ml/min, sample volume 10 µl, UV detector (270 nm). They were validated in terms of specificity, linearity, detection limit, precision, robustness, and solution stability. Analytical concentration levels were selected for the formation of draft regulatory documents. Using the developed analytical technique, samples of RS, API and tablets of malоben and ethmaben were analyzed.Conclusion. A full cycle of research was carried out, an analytical methodology was developed and related impurities were identified in RS, API and FPP of Maloben and Ethmaben.
Quantitative measurement of transthyretin mistargeting by proximity labeling and parallel reaction monitoring
Authors: Lyu Ziqi , Genereux Joseph C. 
Published: November 2023

Introduction: Proximity labeling is a powerful approach for characterizing subcellular proteomes. We recently demonstrated that proximity labeling can be used to identify mistrafficking of secretory proteins, such as occurs during pre-emptive quality control (pre-QC) following endoplasmic reticulum (ER) stress. This assay depends on protein quantification by immunoblotting and densitometry, which sometimes suffers from poor sensitivity.Methods: Here, we integrate parallel reaction monitoring (PRM) mass spectrometry to enable a more quantitative platform and assess how chemical ER stressors impact pre-QC of the model secretory protein transthyretin in HEK293T cells.Results and Discussion: We find that some drug treatments affect labeling efficiency, which can be controlled for by normalizing to APEX2 autolabeling. While some chemical ER stress inducers including Brefeldin A and thapsigargin induce pre-QC, tunicamycin and dithiothreitol do not, indicating ER stress alone is not sufficient. This finding contrasts with the canonical model of pre-QC induction, and establishes the utility of our platform.
Association of genes in hereditary metabolic diseases with diagnosis, prognosis, and treatment outcomes in gastric cancer
Authors: Li Yiping , Li Xiaoqin , Yang Yufei , Qiao Xuehan , Tao Qing , Peng Chen , Han Miao , Dong Kebin , Xu Min , Wang Deqiang , Han Gaohua 
Published: November 2023

BackgroundAberrant metabolism is a major hallmark of cancers and hereditary diseases. Genes associated with inborn metabolic errors may also play roles in cancer development. This study evaluated the overall impact of these genes on gastric cancer (GC).MethodsIn total, 162 genes involved in 203 hereditary metabolic diseases were identified in the Human Phenotype Ontology database. Clinical and multi-omic data were acquired from the GC cohort of the Affiliated Hospital of Jiangsu University and other published cohorts. A 4-gene and 32-gene signature was established for diagnosis and prognosis or therapeutic prediction, respectively, and corresponding abnormal metabolism scores (AMscores) were calculated.ResultsThe diagnostic AMscore showed high sensitivity (0.88-1.00) and specificity (0.89-1.00) to distinguish between GC and paired normal tissues, with area under the receiver operating characteristic curve (AUC) ranging from 0.911 to 1.000 in four GC cohorts. The prognostic or predictive AMscore was an independent predictor of overall survival (OS) in five GC cohorts and a predictor of the OS and disease-free survival benefit of postoperative chemotherapy or chemoradiotherapy in one GC cohort with such data. The AMscore adversely impacts immune biomarkers, including tumor mutation burden, tumor neoantigen burden, microsatellite instability, programmed death-ligand 1 protein expression, tumor microenvironment score, T cell receptor clonality, and immune cell infiltration detected by multiplex immunofluorescence staining. The AUC of the AMscore for predicting immunotherapy response ranging from 0.780 to 0.964 in four cohorts involving GC, urothelial cancer, melanoma, and lung cancer. The objective response rates in the low and high AMscore subgroups were 78.6% and 3.2%, 40.4% and 7%, 52.6% and 0%, and 72.7% and 0%, respectively (all p&lt;0.001). In cohorts with survival data, a high AMscore was hazardous for OS or progression-free survival, with hazard ratios ranged from 5.79 to 108.59 (all p&lt;0.001). Importantly, the AMscore significantly improved the prediction of current immune biomarkers for both response and survival, thus redefining the advantaged and disadvantaged immunotherapy populations.ConclusionsSignatures based on genes associated with hereditary metabolic diseases and their corresponding scores could be used to guide the diagnosis and treatment of GC. Therefore, further validation is required.
Linagliptin and secoisolariciresinol diglucoside attenuate hyperlipidemia and cardiac hypertrophy induced by a high-methionine diet in rats via suppression of hyperhomocysteinemia-induced endoplasmic reticulum stress
Authors: Jalal Israa A. , Elkhoely Abeer , Mohamed Shimaa K. , Ahmed Amany A. E. 
Published: November 2023

Background: Cardiac hypertrophy (CH) is one of the contributing causes of morbidity and mortality. Hyperhomocysteinemia (HHcy) is one of the diseases which may predispose hyperlipidemia and CH. Linagliptin (Lina) and secoisolariciresinol diglucoside (SDG) are known to alleviate a variety of illnesses by reducing oxidative stress and inflammation.Aim: This study aimed to study the effect of HHcy on cardiac tissues, with a special focus on endoplasmic reticulum (ER) stress as a mainstay pathophysiological pathway. In addition, our study examined the protective effect of Lina, SDG, and their combination against HHcy-induced hyperlipidemia and CH in rats.Methods: Seventy-five male Sprague–Dawley rats were randomly divided into five groups, and for 60 days, the following regimen was administered: Group I: rats received distilled water; Group II: rats received methionine (MET) (2 g/kg/day, p.o.); groups III and IV: rats received Lina (3 mg/kg/day, p.o.) and SDG (20 mg/kg/day, p.o.), respectively, followed by MET (2 g/kg/day, p.o.); Group V: rats received Lina and SDG, followed by MET (2 g/kg/day, p.o.).Results: Pretreatment with Lina, SDG, and their combination showed a significant decrease in serum levels of HHcy and an improved lipid profile compared to the MET group. Moreover, both drugs improved cardiac injury, as evidenced by the substantial improvement in ECG parameters, morphological features of the cardiac muscle, and reduced serum levels of cardiac markers. Additionally, Lina and SDG significantly attenuated cardiac oxidative stress, inflammation, and apoptosis. Furthermore, Lina, SDG, and their combination remarkably downregulated the enhanced expression of endoplasmic reticulum (ER) stress markers, GRP78, PERK, ATF-4, CHOP, NF-κB, and SREBP1c compared to the MET-group.Conclusion: Lina and SDG showed cardioprotective effects against HHcy-induced heart hypertrophy and hyperlipidemia in rats.
Sistem Deteksi Penyakit Covid-19 Berdasarkan Gejala Awal Menggunakan Algoritma Naïve Bayes Berbasis Android
Authors: Kurniadi Dede , Mulyani Asri , Rizky Diar Nur 
Published: November 2023

Data penelitian terakhir menunjukkan bahwa masyarakat merasa takut untuk melakukan pemeriksaan ke instansi kesehatan akibat kurangnya pengetahuan Covid-19, sehingga menyebabkan ketidak pedulian dalam aktivitas sehari-hari terhadap dampak dari situasi penyakit Covid-19. Oleh karena itu dibutuhkan sebuah aplikasi sistem deteksi gejala awal penyakit Covid-19 berbasis mobile. Tujuan dari penelitian ini membuat aplikasi sistem deteksi penyakit Covid-19 dengan menerapkan metode pengklasifikasian Naïve Bayes sehingga mempermudah pengguna dalam melakukan tes mandiri gejala awal Covid-19. Metode perancangan yang digunakan adalah Extreme Programming (XP) yang terdiri dari planning, analysis, design, implementation, dan maintenance. Data yang digunakan terdiri dari 2 dataset yaitu dataset untuk pengklasifikasian penyakit Covid-19 dengan jumlah data sebanyak 44.453 dan dataset untuk pengklasifikasian varian Covid-19 berjumlah 128.769. Penelitian ini melakukan 2 kali pemodelan menggunakan Split Data dengan perbandingan 5:5 untuk klasifikasi penyakit Covid-19 dan perbandingan 3:7 untuk klasifikasi varian Covid-19. Hasil penelitian ini berhasil membangun Sistem deteksi penyakit Covid-19 berdasarkan gejala awal menggunakan algoritma Naïve Bayes berbasis android dan telah mampu memprediksi penyakit Covid-19 ke dalam 4 class dengan nilai F1-Score yaitu Allergy 0,98, Cold 0,61, Covid 0,56, dan Flu 0,95, serta gejala yang paling berpengaruh pada class Allergy yaitu CS13 (Loss of taste) dengan nilai 0,50, class Cold yaitu CS3 (Tiredness) dengan nilai 0,52, class Covid yaitu CS12 (Difficulty breathing) dengan nilai 0,51, dan class Flu yaitu CS19 (Sneezing) dengan nilai 0,53, sistem yang dibangun juga mampu memprediksi varian Covid-19 ke dalam 3 class dengan nilai F1-Score yaitu alpha 0,85, delta 0,78, dan omicron 0,93, serta gejala yang paling berpengaruh pada class Alpha yaitu VS3 (Loss of appetite) dengan nilai 0,74, class Delta yaitu VS12 (Cough) dengan nilai 0,87, dan class Omicron yaitu VS10 (Sore throat) dengan nilai 0,67, juga aplikasi berhasil dan dapat dirancang dengan pendekatan Extreme Programming (XP).
James Lovelock (2021). Novaceno. La próxima era de la hiperinteligencia. Barcelona, Paidós. 183 págs. ISBN: 978-84-493-3846-5
Authors: Pazo Labrador Alberto José 
Published: November 2023

Recensión del libro:
James Lovelock (2021). Novaceno. La próxima era de la hiperinteligencia. Barcelona, Paidós. 183 págs. ISBN: 978-84-493-3846-5
مصطلحات قديمة وقيمتها في النقد الأدبي
Authors: المطلبي عبد الجبار يوسف 
Published: November 2023

الإنسان إبن عاداته ، تجري به تجاربه في الحياة ، مما هو ضروري له في مسالك العيش، وتتكرر تلك التجارب في تلك المسالك فيعتادها :أي يكتسب المهارة في أدائها من غير أن يحس انه بذل جهداً كبيراً في تذليلها اللهم ألا في أوائل أدائه لها ، كالمشي مثلاً، والكلام وكثير من العادات التي مرت به ، أو مرّ بها ، وتكرر لقاؤه إياها، فحذقها فيما حذق من مهارات او اكتسبته فقيدته بقيودها الخفية فصار أسيرها بعد أن كان ينشد امتلاكها والانتفاع بها. أو بعد أن ثقفها من مجتمعه الذي ارتبط كل فرد فيه بشباكٍ غير منظورة ، قديمة أو حديثة ، هي نتاج تأثيرات مجموع أفراده بعضهم في بعض ، فتبدو له او لكثير من افراد مجتمعه "مسلمات" يؤدونها من غير مانظرٍ فاحص في صوابها او فائدتها أو في حقيقة طبيعتها. انها "مسلمات" نمرّ بها لانلتفت الى أهميتها أو مغزاها، وهي كثيرة فيما نعده في "الدين او السياسة او الاجتماع … او الفنون". و يهمنا هنا مايتصل بالفنون، وبتحديد أكثر مايتصل بالنقد الأدبي ومصطلحاته ، أو ، في الاقل ،في أمثلة منتخبة من مصطلحاته التي نصطنعها في النقد من غير أن نلتفت الى مالها من الشأن فيما تعني في ذلك الميدان، ميدان النقد ومعاييره التي تقاس بها النصوص الأدبية.
المتن اللغوي في المعجم العربي القديم - دراسة في كيفية المعالجة -
Authors: عيدان حيدر جبار 
Published: November 2023

هناك تقسيم درج عليه الباحثون في المعجم العربي، يصنف التراث المعجمي عند العرب إلى ما يسمى بمعجمات الألفاظ، وكان يغلب على جهود أصحابها الجانب الاستقصائي من جهة، والهاجس التوثيقي من جهة أخرى، وهناك صنف آخر يسمى بمعجمات المعاني مثل المعجمات التي اهتمت بالأضداد وأنواع الصيغ الصرفية وأنواع الأفعال وغيرها.. وقد كانت هذه المعجمات قد أُلّفت تلبية لحاجات الشعراء والكتاب من المعاني والعبارات المناسبة لمختلف الاستعمالات...وسواء أكانت الغاية استقصائية كمية أم موضوعية (نوعية)، فإن الخلفية التي توجه أعمالهم في معظمها هي الإحاطة بالمعنى الغامض لاستجلائه وتفسيره، خصوصا عندما يتعلق الأمر بفهم القرآن الكريم والحديث النبوي الشريف. وقد كانت العادة، قبل ظهور المعجمات، أن يرجع الناس، متى استغلق عليهم لفظ أو اضطرب لديهم معنى من المعاني، إلى (( أهل العلم )) فالعرب كانوا يعتزون بلغتهم التي آثرها الله فجعلها لغة القرآن، وكان فخرهم يتعاظم بسبب ما يرونه من اتساع لغتهم وغنى معجمها إلى حد يرون لغتهم لا حدود لمعانيها وألفاظها، وذلك مدلول ما يؤثر عن الكسائي في قوله (لقد درس من كلام العرب كثير) وكذلك ما يروى عن أبي عمرو بن العلاء، وهو من القراء ومن الرواة الكبار، ان (ما انتهى إليكم مما قالت العرب إلا أقله ولو جاءكم وافرا لجاءكم علم وشعر كثير) وقد كان للرواة أثر في جمع اللغة وتفسير ما غمض منها وكانت لهم مناهج في ذلك، فقد كان ابن عباس ينصح الناس إذا خفي عليهم معنى أن يردوه إلى الشعر، لأن (الشعر ديوان العرب، فإذا خفي علينا الحرف من القرآن الذي أنزله الله رجعنا إلى الشعر فالتمسنا ذلك منه).
التصحيح اللغوي
Authors: مطلوب احمد 
Published: November 2023

اهتم العرب بلغتهم منذ عهد مبكر ، فوضعوا الكتب التي تصونها من الانحراف ، و كان كتاب سيبويه من أوائل الكتب التي جمعت أصول كلام العرب . و من أهم الأسباب تلك العناية باللغة العربية خدمة القران الكريم ، و تصحيح ما انحرف من الالسنة بعد أن اشتهرت العربية في الأصقاع البعيدة عن مواطنها. و اللحن القديم ، و لكنه فشا على السنة العرب و الشعوب التي دخلت في دين الله أفواجا حين ابتعدوا عن موطن الفصاحة ، و قد ذُكر أن رجلا قرأ عند رسول الله – صلى الله عليه و سلم – فلحن ، فقال : " ارشدوا صاحبكم فقد ضل " . و قال عمر بن الخطاب – رضي الله عنه – " و اللهِ لخطؤكم في لسانكم أشدّ عليّ من خطئكم في رميكم " . و يُروى أن كتابا جاء إليه فيه : " من أبو موسى " فكتب إلى صاحب الكتاب : " أن قَنّع كاتبك سوطا تأديبا له على اللحن " ، و كانوا يعدون اللحن ذنبا من الذنوب . و بدأت تقنية اللغة مما شابهها من خروج عن سنن كلام العرب ، و شمل ذلك الخروج عدة جوانب منها :الأول : الخروج على الأصوات العربية ، و ارتضاخ اللكنة.الثاني : تغيير الحركة المؤدي إلى تغيير المعنى .الثالث : تغيير صيغ الألفاظ.الرابع : وضع الألفاظ في غير مواضعها .الخامس : الغلط في حركات الإعراب .