bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS JSA DAN IBPRP BERDASARKAN PERMEN PUPR No.21 TAHUN 2019
Authors: Setiabudi Feri 
Published: November 2023

Tingginya kasus kecelakaan kerja disektor konstruksi, pemerintah telah mengatur penyelengaraan KK dalam Peraturan Menteri serta mewajibkan pelaksanaannya di semua sektor industri. Kementrian PUPR selaku regulator sekaligus pengerak sektor konstruki Nasional menjadikan KK sebagai prioritas dalam pelaksanaan pembangunan nasional. Pelaksanaan KK tidak hanya bermanfaat untuk melindungi para pekerja konstruksi, tetapi juga mampu meningkatkan produktifitas dan kinerja pekerja. Tujuan penelitian adalah mengetahui bagaimana menganalogi bahaya menggunakan JSA dan mengetahui rancangan IBPRP pekerjaan balok. Penelitian ini dimulai denganÂ mengidentifikasi bahaya menggunakan metode JSA dan IBPRP sesuai dengan Permen PUPR No.21 Tahun 2019. Kemudian melakukan validasi kepada pihak proyek dengan metode Forum Group Discusion. Selanjutnya melakukan penilaian risiko pada form IBPRP untuk menentukan nilai kemungkinan dan keparahan. Penentuan tingkat risiko dianalisis dengan tabel dampak dan kemungkinan. Hasil dari penelitian ini yaitu, Penerapan dan pelaksanaan pembuatan JSA dan IBPRP sudah sesuai dengan Permen PUPR No. 21/PRT/M/2019 Tentang Pedoman SMKK dan telah divalidasi oleh pihak proyek dan dinyatakan layak untuk uji coba tanpa revisi. Dari 24 jenis tahap pekerjaan struktur balok yang dianalisis dengan metode IBPRP, didapatkan 5 tingkat risiko yang berbeda yaitu dengan tingkat risiko Exstrim 4%, tingkat risiko Tinggi 8%, tingkat risiko Sedang 67%, tingkat risiko Rendah 21% dan tingkat risiko Nol 0%.Â Kata Kunci: Identifikasi Bahaya, Penilaian Risiko, JSA dan IBPRP, Permen PUPR No.21 Tahun 2019
INVESTIGASI SIFAT TERMAL PERMUKAAN PERKERASAN JALAN
Authors: Ihsan Muhammad , Kushari Berlian , Suparma Latif Budi , Kanitpong Kunnawee 
Published: November 2023

Setiap permukaan perkerasan memiliki sifat yang berbeda-beda yang berpengaruh terhadap lingkungan sekitarnya. Tujuan dari penelitian ini adalah untuk memahami sifat termal dari permukaan perkerasan, seperti profil albedo dan temperatur serta memberikan pertimbangan dalam mengembangkan perkerasan sejuk. Empat jenis permukaan perkerasan yang digunakan, aspal hot mix baru, aspal hot mix lama, chip seal dan permukaan perkerasan beton semen portland. Nilai albedo diselidiki dengan menghitung rasio radiasi yang datang danÂ yang dipantulkan. Profil suhu diselidiki dengan perekaman menerus menggunakan thermocouple. Hasil penelitian menunjukkan bahwa terdapat hubungan negatif antara albedo dengan temperatur dimana semakin tinggi albedo maka semakin rendah temperatur permukaan perkerasan.
PEMANENAN AIR HUJAN (RAINWATER HARVESTING) SEBAGAI ALTERNATIF PENYEDIAAN AIR BERSIH DI DESA MAREGAM
Authors: Nagu Nani - , Anggraini Dewinta - , Darwis Muhammad - 
Published: November 2023

Â Air merupakan salah satu kebutuhan yang sangat penting dalam kehidupan. Penggunaan air sangat beragam untuk keperluan sehari-hari baik untuk memasak, mandi, mencuci dan lain-lain.Pola penggunaan air yang kurang efektif dalam pemanfaatannya mengakibatkan dampak terhadap ketersediaan air di suatu wilayah. Salah satunya di Desa maregam yang terletak di Kecamatan Tidore Selatan Kota Tidore Kepulauan Provinsi Maluku Utara. Berdasarkan uraian di atas maka munculah pemikiran untuk mengelola air hujan dengan menggunakan konsep pemanenan air hujan. Penelitian ini bertujuan untuk mengetahui berapa jumlah kebutuhan air bersih di Desa Maregam, untuk mengetahui berapa banyak air hujan yang dapat di tampung melalui atap untuk memenuhi kebutuhan air bersih dan bagaimana menghitung pemanenan air hujan terhadap kebutuhan masyarakat di Desa Maregam. Jenis penelitian yang dipakai adalah jenis kualitatif dengan menggunakan metode studi kasus. Setelah dilakukan pengolahan data, maka di dapat kebutuhan air bersih rerata masyarakat Desa Maregam adalah sebesar 1.105.320 liter/bulan. Air hujan yang dapat di tampung melalui atap untuk memenuhi kebutuhan air bersih masyarakat di Desa Maregam sebesar 1.482.128 mÂ³.Â
Analisis Pemanfaatan Plastik Polystyrene (PS) senagai Bahan Tambahan Aspal AC-WC dan AC-BC dengan Metode Marshall
Authors: Sulfanita Andi - 
Published: November 2023

ABSTRACT : Availability of Polystyrene (PS) type plastic waste in various surrounding environments, added to the hot asphalt mixture to improve road pavement performance. This study aims to determine the effect of adding Polystyrene (PS) plastic to the Marshall characteristics of AC-WC and AC-BC asphalt based on the 2018 General Highways Specifications. The test results on Marshall characteristics with a mixture of normal asphalt content of 5% and 6% obtained Optimum Asphalt Content (KAO) of 5.5% for each asphalt AC-WC and AC-BC. Marshall testing on AC-WC asphalt with polystyrene materials using 4% and 5% levels. Then the Stability, VMA, VIM, Flow, and Marshall Quotient values increase, while the VFA value decreases with each addition of Polystyrene (PS) content, this indicates the low density of the asphalt mixture against water and air. However, all variations in the levels of plastic additives on AC-WC asphalt met the specifications, while the Marshall test on AC-BC asphalt with polystyrene materials used levels of 4% and 5%. Then the Stability, VFA, Flow, and Marshall Quotient values have increased, while the VMA, and VIM values have decreased with each addition of Polystyrene (PS) content, this indicates that the voids in the aggregate and voids in the mixture are getting smaller, and causing the asphalt to not be able to fill the empty space too much. and aggregate binding. However, only the VIM value at 5% with a value of 2.58% does not meet the specifications between 3% -5%. So, apart from that, all the added ingredients of asphalt plastic AC-BC meet the specifications. Utilizing Polystyrene (PS) type plastic waste in hot asphalt mixtures can improve the quality of Marshall characteristics and can be used as an additive in asphalt flexible pavement.Â Keywordsi : AC-WC, AC-BC, Marshall, KAO, Polystyrene (PS).
Forecasting of Significant Wave Height and Period at Western Waters of Ternate Island, North Maluku
Authors: Lessy Mohammad Ridwan , Abdullah Rommy Mudafar 
Published: November 2023

The water of West Ternate Island is open waters which are very dynamic oceanographic conditions. One of them is ocean waves that are strongly related to wind friction. This study aims to analyze the height and wave period that occurred in the western part waters of Ternate Island based on wind data for 10 years. It is expected that the results of this study will be useful for policymakers in the sustainable management of coastal areas in Ternate City. This research used Wilson Method to estimate the wave height in four seasons.Â The data collected includes the maximum wind direction and speed during the period 2009-2018 obtained from the Meteorological and Geophysical Station of Baabullah Airport, Ternate City. Wind data will be transformed to stability correction and wind stress factor to determine height and period of wave. The results showed that in The West Season and Transition Season 1 (TS 1), the wind direction is more dominant moving from the Northwest to the Southeast with an average maximum speed of 17.71 knots. During the observation year, significant wave height (Hs) formed in the Western Season period as high as 1.25 m â€“ 2.75 m while in Transition Season 1 the wave height was between 1.0 m â€“ 2.31m. While in the Eastern Season period the wave height that occurs ranges from 0.61 m â€“ 1.55 m and in the MP2 period ranges from 0.67 m â€“ 1.43 m. In the Western Season, the wave period ranges from 4.67 â€“ 6.82 seconds, and in Transition Season 1 between 4.45 â€“ 6.44 seconds. While in the eastern season the wave period ranges from 3.29 â€“ 4.89 seconds and in Transition Season 2 (TS 2) ranges from 3.43 â€“ 4.68 seconds.
Kontrol Motor Stepper pada Mesin Pembuat Segitiga Komponen Packing di PT Surabaya Autocomp Indonesia berbasis PLC-HMI
Authors: Aliftinan Dafi'ah , Rifa'i Muhammad , Fauziyah Mila 
Published: November 2023

Segitiga komponen packing merupakan salah satu komponen pendukung dalam proses packing di PT. Surabaya Autocomp Indonesia yang memiliki beberapa ukuran. Dalam menghasilkan ukuran-ukuran tersebut, diperlukan suatu sistem yang presisi, salah satunya menggunakan motor stepper.
Rangkaian pulsa digital dikirimkan ke motor stepper untuk mengontol kecepatan dan sudut rotasi pada motor. Metode penelitian yang diterapkan adalah kuantitatif eksperimen, dilakukan dengan mengkaji persamaan matematis yang digunakan untuk rumus konversi. HMI akan memberikan input nilai jarak kepada PLC. Kemudian PLC akan mengkonversi nilai jarak menjadi nilai pulsa. Motor stepper diberikan pulsa oleh PLC melalui driver motor untuk mengendalikan langkah (step) motor supaya berputar sesuai input yang diinginkan HMI
Setelah melakukan tiga kali percobaan nilai konversi, didapat nilai error terkecil pada percobaan ketiga yaitu, 0.19% dan 0.04%. Hal ini dikarenakan faktor konversi yang kurang akurat dan faktor mekanik yang kurang presisi dalam perakitannya.
IMPLEMENTASI KONVERTER BERBASIS SEPIC PADA MODUL SOLAR PANEL DENGAN ALGORITMA FUZZY LOGIC
Authors: Pattria Pattria Dwin Cahyawati , Radianto Donny , Safitri Hari Kurnia 
Published: November 2023

Sumber energi matahari merupakan salah satu energi terbarukan yang ramah lingkungan dan dapat dijadikan sebagai energi alternatif. Dengan menggunakan modul solar panel, maka energi matahari dapat diubah menjadi energi listrik. Terdapat dua parameter yang mempengaruhi keluaran modul solar panel yaitu intensitas radiasi matahari dan temperatur yang mengakibatkan keluaran dari modul solar panel tidak stabil. Pada sistem pengisian aki memerlukan keluaran yang stabil pada 14 V, sehingga ketidak stabilan pada keluaran modul solar panel merupakan masalah yang dapat menyebabkan over voltage pada aki. Untuk itu, sistem ini menggunakan konverter berjenis SEPIC yang dapat menaikkan dan menurunkan tegangan. Agar keluaran lebih optimal, maka sistem menggunakan metode fuzzy logic kontrol. Dengan metode dan rangkaian konverter yang digunakan tersebut diharapkan tegangan output pada solar panel akan stabil untuk melakukan pengisian pada aki. Sedangkan waktu pengisian aki yaitu 3 jam dengan tenganan awal sebesar 11.5 V dan tegangan setelah pengisian sebesar 12.54 V. Pada saat proses pengisian aki, tegangan akan bertambah dan arus akan semakin kecil ketika aki penuh.
The different outcomes in the elderly with subclinical hypothyroidism diagnosed by age-specific and non-age-specific TSH reference intervals: a prospectively observational study protocol
Authors: Zhang Xueqi , Li Yang , Jin Jing , Wang Huangman , Zhao Bozun , Wang Songwen , Shan Zhongyan , Teng Weiping , Teng Xiaochun 
Published: November 2023

IntroductionSubclinical hypothyroidism (SCH) is a common endocrine disorder characterized by elevated thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) levels. The overdiagnosis and overtreatment of SCH in elderly patients have become concerns as TSH levels naturally increase with age. Studies have shown that many elderly patients with SCH can recover without treatment, and the administration of levothyroxine (L-T4) does not improve their prognosis. Therefore, It is necessary to establish age-specific reference ranges for TSH in elderly individuals to aid in clinical decision-making and prevent overdiagnosis.MethodsThis is a multicenter prospective study that focuses on Chinese elderly patients with SCH who have TSH levels below 10 mU/L. After obtaining the informed consent of the patients, their initial diagnosis information will be registered, and they will be asked to fill out questionnaires such as the Montreal Cognitive Assessment-Basic (MoCA-B), Hamilton Depression Scale (HAMD), Hypothyroidism Symptom Questionnaire (SRQ), frail scale(FRAIL), fatigue scale, and EQ-5D. In addition, thyroid function tests, blood lipid analysis, carotid artery ultrasound, and thyroid ultrasound examinations will be conducted. Patients will also be grouped according to FT4 levels, the changes in FT4 and its relationship with TSH can also be described. For patients over 80 years old, a decrease in FT4 will be used as an endpoint event, while for patients between 60-80 years old, TSH levels greater than or equal to 10mIU/L or a decline in FT4 will be used as the endpoint event. The TSH reference intervals of the general and elderly populations will be used to calculate medical costs associated with multiple follow-ups of patients, and a social-economic analysis will also be conducted.DiscussionThis study will prospectively observe elderly patients with SCH who are screened using both age-specific and non-age-specific TSH reference ranges for the elderly population. We will compare the results of elderly patients diagnosed with SCH using different reference ranges and analyze their association with FT4 to identify meaningful SCH patients and reduce over diagnosis and over treatment of elderly SCH.EthicsThe Medical Science Research Ethics Committee of the First Affiliated Hospital of China Medical University approved this study (ID: AF-SOP-07-1.1-01). The results will be published in an open-access journal.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2300070831.
Proteome profiling identifies circulating biomarkers associated with hepatic steatosis in subjects with Prader-Willi syndrome
Authors: Pascut Devis , Giraudi Pablo J. , Banfi Cristina , Ghilardi Stefania , Tiribelli Claudio , Bondesan Adele , Caroli Diana , Minocci Alessandro , Grugni Graziano , Sartorio Alessandro 
Published: November 2023

IntroductionPrader-Willi syndrome (PWS) is a rare genetic disorder characterized by loss of expression of paternal chromosome 15q11.2-q13 genes. Individuals with PWS exhibit unique physical, endocrine, and metabolic traits associated with severe obesity. Identifying liver steatosis in PWS is challenging, despite its lower prevalence compared to non-syndromic obesity. Reliable biomarkers are crucial for the early detection and management of this condition associated with the complex metabolic profile and cardiovascular risks in PWS.MethodsCirculating proteome profiling was conducted in 29 individuals with PWS (15 with steatosis, 14 without) using the Olink Target 96 metabolism and cardiometabolic panels. Correlation analysis was performed to identify the association between protein biomarkes and clinical variables, while the gene enrichment analysis was conducted to identify pathways linked to deregulated proteins. Receiver operating characteristic (ROC) curves assessed the discriminatory power of circulating protein while a logistic regression model evaluated the potential of a combination of protein biomarkers.ResultsCDH2, CTSO, QDPR, CANT1, ALDH1A1, TYMP, ADGRE, KYAT1, MCFD, SEMA3F, THOP1, TXND5, SSC4D, FBP1, and CES1 exhibited a significant differential expression in liver steatosis, with a progressive increase from grade 1 to grade 3. FBP1, CES1, and QDPR showed predominant liver expression. The logistic regression model, -34.19 + 0.85 * QDPR*QDPR + 0.75 * CANT1*TYMP - 0.46 * THOP1*ALDH1A, achieved an AUC of 0.93 (95% CI: 0.63-0.99), with a sensitivity of 93% and specificity of 80% for detecting steatosis in individuals with PWS. These biomarkers showed strong correlations among themselves and were involved in an interconnected network of 62 nodes, related to seven metabolic pathways. They were also significantly associated with cholesterol, LDL, triglycerides, transaminases, HbA1c, FLI, APRI, and HOMA, and showed a negative correlation with HDL levels.ConclusionThe biomarkers identified in this study offer the potential for improved patient stratification and personalized therapeutic protocols.
Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
Authors: Wang Bingduo , Wöhler Aliona , Greven Johannes , Salzmann Rebekka J. S. , Keller Cindy M. , Tertel Tobias , Zhao Qun , Mert Ümit , Horst Klemens , Lupu Ludmila , Huber-Lang Markus , van Griensven Martijn , Mollnes Tom Erik , Schaaf Sebastian , Schwab Robert , Strassburg Christian P. , Schmidt-Wolf Ingo G. H. , Giebel Bernd , Hildebrand Frank , Lukacs-Kornek Veronika , Willms Arnulf G. , Kornek Miroslaw T. 
Published: November 2023

BackgroundDespite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers of decision-making in polytrauma.ObjectiveOur Liquid Biopsy in Organ Damage (LiBOD) study aimed to differentiate polytrauma with organ injury from polytrauma without organ injury. We analysed of blood-borne small EVs at the individual level using a combination of immunocapture and high-resolution imaging.MethodsTo this end, we isolated, purified, and characterized small EVs according to the latest Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines from human blood collected within 24 h post-trauma and validated our results using a porcine polytrauma model.ResultsWe found that small EVs derived from monocytes CD14+ and CD14+CD61+ were significantly elevated in polytrauma with organ damage. To be precise, our findings revealed that CD9+CD14+ and CD14+CD61+ small EVs exhibited superior performance compared to CD9+CD61+ small EVs in accurately indicating polytrauma with organ damage, reaching a sensitivity and a specificity of 0.81% and 0.97%, respectively. The results in humans were confirmed in an independent porcine model of polytrauma.ConclusionThese findings suggest that these specific types of small EVs may serve as valuable, non-invasive, and objective biomarkers for assessing and monitoring the severity of polytrauma and associated organ damage.
Measuring the impact of monoclonal antibody therapies
Authors: Lim Ka Keat , Ng Kenrick , Balachandran Sathiyaa , Russell Mark D. , Boalch Amy , Sinclair Alasdair , Coker Bolaji , Vinnakota Krishna , Mansoor Rashid , Douiri Abdel , Marks Lara V. , Sacks Steven 
Published: November 2023

ObjectiveMonoclonal antibody (Mab) treatments have significantly improved the quality and quantity of life, but they are some of the most expensive treatments, resulting in a degree of hesitancy to introduce new Mab agents. A system for estimating the effect of Mab drugs, in general, would optimally inform health strategy and fully realize how a single scientific discovery can deliver health benefits. We evaluated such a method with several well-established Mab regimens.MethodsWe selected five different Mab regimens in oncology and rheumatology in England. We carried out two systematic literature reviews and meta-analyses to assess health outcomes (Health Assessment Questionnaire-Disability Index for rheumatoid arthritis; overall mortality for melanoma) from real-world data and compared them to the outcomes from randomized control trials (RCTs). We applied economic modeling to estimate the net monetary benefits for health outcomes for the estimated patient population size for each Mab regimen.ResultsMeta-analyses of 27 eligible real-world data (RWD) sets and 26 randomized controlled trial (RCT) sets found close agreement between the observed and expected health outcomes. A Markov model showed the net positive monetary benefit in three Mab regimens and the negative benefit in two regimens. However, because of limited access to NHS data, the economic model made several assumptions about the number of treated patients and the cost of treatment to the NHS, the accuracy of which may affect the estimation of the net monetary benefit.ConclusionRCT results reliably inform the real-world experience of Mab treatments. Calculation of the net monetary benefit by the algorithm described provides a valuable overall measure of the health impact, subject to the accuracy of data inputs. This study provides a compelling case for building a comprehensive, systematized, and accessible database and related analytics, on all Mab treatments within health services.
Impact of omega-3 fatty acids supplementation on the gene expression of peroxisome proliferator activated receptors-γ, α and fibroblast growth factor-21 serum levels in patients with various presentation of metabolic conditions: a GRADE assessed systematic review and dose–response meta-analysis of clinical trials
Authors: Ahmadi Amirhossein Ramezani , Shirani Fatemeh , Abiri Behnazi , Siavash Mansoor , Haghighi Sasan , Akbari Mojtaba 
Published: November 2023

There is some debate about the effects of omega-3 fatty acids on the regulation of adipose tissue related genes. This systematic review and meta-analysis aimed to evaluate the effects of omega-3 fatty acids supplementation on the gene expression of peroxisome proliferator activated receptors (PPAR-α and PPAR-γ) and serum fibroblast growth factor-21 (FGF-21) levels in adults with different presentation of metabolic conditions. To identify eligible studies, a systematic search was conducted in the Cochrane Library of clinical trials, Medline, Scopus, ISI Web of Science, and Google Scholar up to April 2022. Eligibility criteria included a clinical trial design, omega-3 fatty acids supplementation in adults, and reporting of at least one of the study outcomes. Effect sizes were synthesized using either fixed or random methods based on the level of heterogeneity. Fifteen studies met the inclusion criteria. Omega-3 fatty acids supplementation significantly increased the PPAR-γ (10 studies) and PPAR-α (2 studies) gene expression compared to the control group (WMD: 0.24; 95% CI: 0.12, 0.35; p &lt; 0.001 and 0.09; 95% CI: 0.04, 0.13; p &lt; 0.001, respectively). Serum FGF-21 (8 studies) levels exhibited no significant change following omega-3 fatty acids supplementation (p = 0.542). However, a dose–response relationship emerged between the dose of omega-3 fatty acids and both PPAR-γ gene expression and serum FGF-21 levels. Overall, this study suggests that omega-3 fatty acids supplementation may have positive effects on the regulation of adipose tissue related genes in patients with various presentation of metabolic condition. Further research is needed to validate these findings and ascertain the effectiveness of this supplementation approach in this population.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, CRD42022338344.