bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of levetiracetam‐induced thrombocytopenia
Authors: Oghlakian Roger , Nock Charles , Koubeissi Mohamad 
Published: October 2023

ABSTRACTRare cases of levetiracetam‐induced thrombocytopenia have been reported in the literature. We report a case of glioblastoma multiforme and partial epilepsy treated with levetiracetam with subsequent development of thrombocytopenia. After ruling out all other possible causes of a decreased platelet count, we conclude that levetiracetam was the cause of this adverse event.
Features of regulation of hepcidin and ferroportin in cancer patients (literary review)
Authors: Blindar V. N. , Zubrikhina G. N. , Davydova T. V. , Dobrovolskaya M. M. 
Published: October 2023

Background. The pathways of iron acquisition, outflow, storage and regulation are disrupted in cancer, which suggests that the reprogramming of iron metabolism is one of the central aspects of the survival of tumor cells.Aim. Is to review and generalize modern literature data on the regulation of hepcidin, ferroportin and prospects for the correction of iron metabolism in cancer patients.Materials and Methods. The paper presents the results of international and domestic studies of the peculiarities of iron metabolism and the prospects for its correction in cancer patients. The search for relevant sources was carried out in the web of Science, PubMed, Medline, eLibrary.ru systems for 1988–2023. Of the analyzed studies 61, the most relevant, were used to write a systematic review.Results. Over the past decade, a new understanding has emerged of the role of proteins, in particular hepcidin and ferroportin, which regulate cellular iron in cancer growth, angiogenesis and metastasis. New treatment methods with hepcidin-modifying strategies and stabilizers of hypoxia-induced factors are emerging, but their therapeutic efficacy for correcting iron metabolism in cancer patients needs to be evaluated and clinical trials.Conclusion. Analysis of the literature data has shown the high relevance of studies of the regulation of hepcidin and ferroportin in cancer patients and the need for further study of this problem.
Schisandrin and Schisantherin A in Multiphytoadaptogen for Preventive Oncology
Authors: Bocharova O. A. , Kazeev I. V. , Shevchenko V. E. , Ionov N. S. , Sheichenko O. P. , Bocharov E. V. , Karpova R. V. , Kucheryanu V. G. , Lagunin A. A. , Filimonov D. A. , Kosorukov V. S. , Poroikov V. V. , Tutelyan V. A. , Pyatigorskaya N. V. 
Published: October 2023

Background. The original herbal formula of Multiphytoadaptogen (MPhA) for preventive oncology developed by the N. N. Blokhin Center of Oncology containing phytocomponents from Schisandra chinensis (Turcz.) Baill (Schisandraceae), has been investigated in vitro, in vivo. Preliminary efficiency in clinical trials has also been obtained. This was allowed because MPhA in Russia is registered as a parapharmaceutical agent and therefore standardized according to established requirements. However, due to the high efficiency of MPhA, a detailed study of the chemical composition and standardization of it is required, including the Schisandra chinensis active components, which turned out to be translocated into MPhA as a result of the extraction technology developed.The aim of the study was to identify the Schisandra chinensis biologically active substances in MPhA and to evaluate the biological activity profiles of the identified phytocomponents using in silico analysis.Materials and methods. we used high performance liquid chromatography in combination with mass spectrometry (HPLC–MS / MS). Chromatography was performed on an ACQUITY UPLC BEH C18 column in a gradient mode. A TSQ Vantage triple quadrupole mass spectrometer with electrospray ionization was used. we performed in silico analyzes of Schisandrin and Schisantherin A biological activity spectra using computer programs PASS and PharmaExpert.Result. The secondary metabolites lignans Schisandrin and Schisantherin A were identified in the herbal formula MPhA. Schisandrin and Schisantherin A activities, according the scientific literature and in silico analysis, correspond to the properties studied for MPhA which therefore fits into the concept of medication for preventive oncology.Conclusion. The determined secondary metabolites can be used for identification, standardization and quality testing of the herbal formula MPhA.
De wondere wegen van La Salette. Nederlandstalige literatuur in het Tsjechisch versus bekeringen tot het katholicisme
Authors: Engelbrecht Wilken 
Published: October 2023

De industriële revolutie veranderde de maatschappij grondig. De meeste Europese landen veranderden van een agrarische in een industriële maatschappij. De steden groeiden fors, er ontstond een groot proletariaat en de ontkerkelijking nam toe. De nieuwe politieke stromingen van de 19e eeuw, het liberalisme en socialisme waren sterk antiklerikaal, in België meer dan in Nederland.
Midden 19e eeuw vonden er vele Mariaverschijningen plaats, de eerste was die van La Salette in 1846. De verschijningen vonden steevast plaats op het platteland, aan eenvoudige mensen, met een oproep tot persoonlijke bekering en apocalyptische boodschappen. De katholieke kerk aarzelde om deze te erkennen. La Salette had sterke invloed op verschillende decadente en symbolistische dichters, van wie Léon Bloy (1846-1917) de belangrijkste was. Bloy beïnvloedde zowel de Nederlander Pieter van der Meer de Walcheren (1880-1970), als de Tsjech Josef Florian (1873-1941). Rond beiden ontstonden kringen van katholieke of katholiek geworden literaten.
De Tsjechische leden van de groep rond Florian vertaalden – soms via vertalingen van Van de Meer de Walcheren in het Frans – Middelnederlandse en andere mystieke en katholieke literatuur, vooral poëzie. La Salette bewerkstelligde zo de transfer van een specifiek deel van de Nederlandstalige literatuur naar het Tsjechische veld.
DIFFUSIVE AND LABYRINTH NARRATIVE UNCERTAINTY IN ENGLISH POSTMODERN SHORT-SHORT STORIES
Authors: Zavarynska M. S. 
Published: October 2023

In the article there is grounded the notion of diffusive and labyrinth narrative uncertainty in English postmodern short-short stories. In our investigation, there is proved that the emergence of narrative uncertainty is caused by specific narrative techniques such as diffusion and labyrinth which we identify manifestations of the narrative-rhizomatic principle of text form. Thus, the basis of narrative uncertainty creation is the mixture of a narrative technique (diffusion or labyrinth), compositional modifications and linguo-stylistic devices (irony, lexical repetition, personification). Uncertainty as a transversal postmodern idea is traced in experimental texts through unconventional text building, modified text compositional structure. Narrator of a short-short story creates a narrative with the purpose of establishing a permanent hesitation in the interpreting at each level of text compositional structure. Thus, the emergence of compositional modifications can be observed at content level, formal level, and formal-content level which create a specific symbol at figurative-symbolic level. Compositional modifications at one of the abovementioned levels serve as the principal agent of the specific type of narrative uncertainty creation — diffusive or labyrinth narrative uncertainty. A preliminary analysis of English postmodern short-short stories has shown that compositional modifications at the formal and formal-content levels function as a key forming agent for diffusive narrative uncertainty. As to labyrinth narrative uncertainty, compositional modifications at content level, formal level, and formal-content are dominant. The leading role in the uncertainty formation belongs to narrator. Narrator builds a narrative in such a manner that it becomes complicated to interpret. That fact characterize narrator as unreliable storyteller. Diffusive narrative uncertainty is actualized by means of multiple narrator, whereas labyrinth narrative uncertainty through heterodiegetic narrator in extradiegetic situation. Perception of English postmodern short-short stories with the expressions of narrative uncertainty demands from narratator (reader) flexible mindset, openness to different interpretations and readiness for active usage of cognitive skills.
TO THE QUESTION OF GENESIS OF STYLISTIC DEVICES
Authors: Pasternak T. A. 
Published: October 2023

The article is devoted to the study of the evolution of stylistic devices in scientific research and the birth of stylistics. The methodological base consists of general scientific methods: analysis, synthesis and generalization of information from historical sources and practical research of scientists in stylistics and rhetoric. The analysis revealed that stylistic devices, as an efficient and impactful way of expressing thoughts and influencing the audience, contributed to the emergence of such a science as stylistics. The main sources of stylistics were the national language, dialects, classical and modern literature, works of artists, and mass media. The theoretical basis for the development of stylistics was rhetoric, linguistics, psychology and logic. Stylistics can be broadly defined as the linguistic science of the means of expression and the regularities of the functioning of language, determined by the most appropriate use of language units in the text, depending on the content of the statement, goals, situation and sphere of communication. The article also considers the issue of classification of stylistic devices in modern domestic and foreign linguistics. Due to the diversity and multifacet nature of this issue in modern stylistics, there is a certain variety of approaches to the classification of stylistic devices. Depending on the focus of the analysis, researchers distinguish: lexical-grammatical, rhetorical, discursive-pragmatic, functional-stylistic classifications, as well as the classification of emotional language, stylistic figures and stylistic techniques. In the English-speaking tradition, stylistic devices are classified by the type of influence on the target audience: logos, pathos, ethos, and kairos. Another approach involves the division of rhetorical figures into 3 diverse groups: sound-related, order-related and meaning-related.
Constitutional risk factors for the development of glaucoma and cataracts in the Europioid population of Russia
Authors: Konenkov V. I. , Shevchenko A. V. , Prokofiev V. F. , Trunov A. N. , Chernykh V. V. 
Published: October 2023

Aim. To identify endogenous risk factors for the development of glaucoma and cataracts based on the results of a comparative analysis of the nature of complex genetic trait distribution, including variants of genes for a number of cytokines and receptors for them, metalloproteinases, and their tissue inhibitors included in the genome of patients.Materials and methods. The study included 501 people of the Caucasian race born and living in the Siberian region of Russia. They were divided into three groups of patients – patients with primary open-angle glaucoma (POAG) (n = 99), patients with senile cataract (n = 100), and the control group (n = 302) without ophthalmic pathology. Genotyping of the analyzed polymorphic loci was carried out by real-time PCR using the SYBRGreen I dye and TaqMan probes and by restriction fragment length polymorphism (RFLP) for different polymorphisms.Results. The results of the study on the frequency of the analyzed genetic traits among patients with POAG compared to the control group showed the presence of combined genetic traits. The frequency of their detection in POAG was high and characterized by the two-digit value of the odds ratio, high values of specificity (99–100%), and high diagnostic coefficient. A direct comparison of the distribution of two ensembles of genes which protein products are involved in the extracellular matrix remodeling revealed a significant number of genetic traits characteristic of both diseases. This indicates significant differences in the implementation of the genetic predisposition to their development.Conclusion. The data obtained indicate the possibility of developing reliable laboratory criteria (riskometers) for predicting predisposition to the development of POAG and early diagnosis at the stage of preclinical manifestations.
The role of endosarcomeric cytoskeleton proteins in the mechanisms of left ventricular diastolic dysfunction: focus on titin
Authors: Kalyuzhin V. V. , Teplyakov A. T. , Bespalova I. D. , Kalyuzhina E. V. , Chernogoryuk G. E. , Terentyeva N. N. , Grakova E. V. , Kopeva K. V. , Usov V. Yu. , Garganeeva N. P. , Livshits I. K. , Petrova I. V. , Lasukova T. V. 
Published: October 2023

Recognizing the fact that isolated left ventricular (LV) diastolic dysfunction (DD) underlies approximately 50% of all heart failure cases requires a deep understanding of its principal mechanisms so that effective diagnostic and treatment strategies can be developed. Despite abundance of knowledge about the mechanisms underlying DD, many important questions regarding the pathophysiology of diastole remain unresolved. In particular, the role of endosarcomeric cytoskeleton pathology in the deterioration of the so-called active (relaxation of the LV myocardium and the atrioventricular pressure gradient at the beginning of diastole, closely related to it in a healthy heart) and passive (myocardial stiffness) characteristics of diastole needs to be clarified.The lecture briefly discusses the complex hierarchy of DD mechanisms (from the sarcomere to the whole heart) and covers the role of the giant protein titin in the latter, which is the main determinant of intracellular stiffness. Impairment of myocardial relaxation and deterioration of its wall compliance under a wide range of pathological conditions (pressure overload, ischemia, inflammation, cardiotoxic effects, oxidative stress, etc.) underlying DD can be explained by a shift in titin expression toward its more rigid N2B isoform, hypophosphorylation by protein kinases A and G or dephosphorylation by serine / threonine phosphatase 5 of its molecule in the extensible protein segment containing a unique N2B sequence, hyperphosphorylation of PEVK regions of titin by protein kinase C, as well as inhibition of the Ca2+-dependent titin – actin interaction.The results of deciphering these mechanisms can become a tool for developing new approaches to targeted therapy for diastolic heart failure that currently does not have effective treatment, on the one hand, and the key to understanding the therapeutic effects of drugs already used to treat chronic heart failure with preserved LV ejection fraction, on the other hand.
Paridade entre histórias indígenas e ocidentais
Authors: Oliveira Genaro 
Published: October 2023

O artigo reflete sobre os desafios de ensinar história no contexto atual de reformas curriculares na Nova Zelândia. Em particular, discuto meus aprendizados e obstáculos, como brasileiro e professor de uma universidade pública, para implementar um currículo de história pioneiro no país. Na primeira parte, apresento um breve histórico dos contextos de ensino de história na Nova Zelândia, com foco no atual de processo reformulação do atual currículo national neozelandês o qual, entre tantas mudanças significativas, se inspira em um princípio pioneiro intitulado mana ōrite mō te mātauranga, que pretende dar equidade epistemológica entre tradições de conhecimento indígenas e ocidentais. Na segunda parte, detalho e reflito sobre minhas próprias iniciativas em sala de aula ao repensar “o que” e “como?” ensinar história para futuro professores de história neozelandeses no atual contexto descolonizador de mudanças políticas e epistemológicas.
Ausencias y presencias en la América colonial
Authors: González Barrios Marcia 
Published: October 2023

El artículo parte de consideraciones generales en torno a la Historia de las mujeres y el enfoque de género en la clase de historia en el contexto de mi práctica docente, abordando la resignificación de experiencias pasadas, por un lado, y reflexionando sobre un proyecto que dota de mayor complejidad a la acción docente, por otro. Lo hace, en primer lugar, describiendo y analizando una secuencia de actividades propuestas a los alumnos, buscando el análisis comparativo de la crónica de Ulrico Schmidl y la carta de Isabel de Guevara durante el proceso de colonización del Río de la Plata. Y, en segundo lugar, reflexiona sobre las posibilidades de incorporar desde dicho enfoque algunos aspectos destacables de las experiencias de Mencía Calderón y Sor Juana Inés de la Cruz.
Resenha de Ana Zavala e outros autores (2019) “Pensar, repensar, mudar. Quando na minha aula de história alguma coisa tem que ser diferente”. Biblioteca Nacional do Uruguai
Authors: Pappier Viviana , Galina Rubinstein Aylen 
Published: October 2023

Reseña de Ana Zavala y otres autores (2019) “Pensar, repensar, cambiar. Cuando en mi clase de historia algo tiene que ser de otra manera”. Biblioteca Nacional de Uruguay
POST-INDUSTRIAL MINING COMMUNITIES: ASPECTS ON GEOECOLOGY OF QUALITY OF LIFE
Authors: Offenberg Iulian , Frățilă Cristian Ovidiu , Iliaș Ioana Tiberia , Iliaș Nicolae , Offenberg Alexandra , Radu Sorin Mihai , Fetiniuc Valentina 
Published: October 2023

The multidisciplinary nature of quality of life calls for appropriate definitions of the concept. Although it is specific to the field of sociology, it appears more and more often in ecology, economy, health, climatology, etc. The phenomenon of metamorphosis thus involves the different fields with activities that produce natural and technical changes. The modification of natural systems and their transformation due to natural-technical causes, characteristic of post-industrial mining areas, brings the new fields of research closer to the geographical environment. The analysis of the quality of life of the communities in these areas involves a transdisciplinary approach (between and within various disciplines as well as beyond any of them) to understand the physiognomy and health of landscapes, respectively the ecology of landscapes loaded with life resources. Through the lens of geotectonic movements in the last period of time, in addition to safe underground mining, ensuring security and health in public and private above-ground spaces requires the need to analyze the real situation, primarily in public institutions, in the public and private health system (hospitals, ambulatories). This paper briefly reviews the geoecology of quality of life, focusing on the most important definitions of the concept and highlighting the elements applicable to post-industrial mining areas.
High-precision algorithm for grain segmentation of thin sections by multi-angle optical-microscopic images
Authors: Murtazin Timur , Kayumov Zufar , Morozov Vladimir , Akhmetov Radik , Kolchugin Anton , Tumakov Dmitrii , Nurgaliev Danis , Sudakov Vladislav 
Published: October 2023

ABSTRACT
This paper introduces an algorithm for automating the analysis of petrographic thin-section images of sandstones and siltstones. The images of thin sections are obtained in polarized light at magnifications providing good image quality. In addition, the images for each section are obtained at different angles of rotation of the microscope stage. Augmentation is applied to the obtained photographs: the number of images increases due to rotations, shifts, and rescaling of the image. For training the neural network of the Mask R-CNN architecture, transfer learning is used, with initial weights obtained from a huge variety of nongeological images. The results of image segmentation using Mask R-CNN are compared to the Watershed algorithm results and the U-Net network for two metrics. According to the standard Intersection over Union metric, U-Net for high-quality images and Watershed for blurry images show the best results with a slight superiority. However, according to the Grain Size Metric, which evaluates the accuracy of grain-size measurement, the best accuracy (over 95%) is shown by Mask R-CNN. The grain-size analysis is done, and the porosity of the studied petrographic sections is determined. The use of the proposed approaches in the study of thin sections will significantly reduce the time for obtaining the results of grain-size-distribution analysis and porosity determination.
This article is the result of multidisciplinary collaboration between geologists and programmers. This has allowed for the merging of profound knowledge in the field of geology with cutting-edge data processing technologies. By employing the presented methodology, geologists can devote more time to interpreting results rather than obtaining them, which in turn enhances the efficiency of research work. The benefits of using this methodology are not limited to just speeding up the process: it also allows for increased accuracy and reliability of the analysis, minimizing human error.
Short-term feeding outcomes in preterm twins with birthweight difference: a comparison between the larger and smaller infants
Authors: Cui Qiliang , Li Ying , Tong XiaoMei , Zheng He , Yang Chunxia , Wei Shen , Ding Yueqin , Liu Jin , Meng Qiong , Zhang Aiqin , Jiang Hong , Yan Wenkang , Qiu Jianwu , We Xian , Zhang Yayu , Lin Xiaobo , Liu Lijun , Jin Ya , Wei Youfen , Zhang Weixing , Yang Xiufang , Wang Yitong , Cai Yangfan 
Published: October 2023

Abstract
Background:This study analyzed and compared the current status of short-term feeding outcomes in preterm twins with birthweight difference to provide an evidence-based medicine basis for optimizing enteral feeding in preterm twins.
Methods:A retrospective and multi-center study was conducted in 11 provinces of China including 21 neonatal intensive care units (NICUs). The clinical data on preterm twins were collected, and grouped into the larger and smaller ones according to the birthweight was relatively higher or lower in each paired twin. Short -term feeding outcomes were analyzed and compared between groups.
Results:A total of 434 pairs of twins were available for further analysis, with an average gestational age of 34.56 ±1.60 weeks and an average birth weight discordance of 12.60 ± 9.57%.As a whole,the median age at achieving total enteral feeding was 9 day after birth,and the average maximum volume of enteral feeding was as 132.07±26.43 ml/kg.d.No significant differences were found between the two groups in terms of feeding intolerance, necrotizing enterocolitis and median age at achieving total enteral feeding.Multivariate logistic regression analysis showed, compared to larger infants, smaller infants were more likely to achieve total enteral feeding(aOR=1.41,95%CI 1.01-1.97,P=0.044), have higher amount of enteral feeding(aOR=1.46,95%CI 1.01-2.11,P=0.046 ), and become extrauterine growth retardation of weight at discharge(aOR=4.51,95%CI 3.03-6.79,P=0.000), but not have increased growth retardation during hospitalization(P> 0.05).
Conclusions:The current status of enteral feeding in preterm twins was not optimistic. Smaller ones seem to receive a better enteral nutrition supply compared with larger ones.