bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment outcome and prognostic factors of inverted papilloma involving the frontal sinus
Authors: Cho Sung‐Woo , Kim Su Geun , Han Doo Hee , Kim Hyun Jik , Kim Jeong‐Whun , Kim Dong‐Young , Rhee Chae‐Seo , Won Tae‐Bin 
Published: December 2023

AbstractObjectivesThis study aimed to evaluate the characteristics and treatment outcomes of inverted papillomas involving the frontal sinus.MethodsPatients treated for inverted papilloma involving the frontal sinus between 2003 and 2020 were reviewed. Tumors were classified based on their extent (Extent 1: partially encroaching on the frontal sinus; Extent 2: completely filling the frontal sinus; Extent 3: eroding bony borders beyond the frontal sinus) and site of origin (Origin 1: originating outside the frontal sinus and prolapsing into the frontal sinus; Origin 2: originating from the frontal sinus walls medial to the vertical plane of the lamina papyracea; Origin 3: originating from the frontal sinus walls lateral to the vertical plane of the lamina papyracea). Treatment outcomes including tumor recurrence and patency of the frontal recess were analyzed according to tumor characteristics and surgical treatment modalities.ResultsA total of 49 surgical cases were analyzed. Extent 1 were the most common type (n = 27), followed by Extent 2 (n = 15), and Extent 3 (n = 7). The most common sites of origin were Origin 1 (n = 23), followed by Origin 2 (n = 15), and Origin 3 (n = 11). Overall, there were nine recurrences (18.4%). Recurrence was not associated with tumor extent, whereas tumor origin, particularly Origin 3 was associated with higher recurrence; 1/23 (4.3%) for Origin 1, 3/15 (20.0%) for Origin 2, and 5/11 (45.5%) for Origin 3 (Log‐rank p < .001). Draf III frontal sinusotomy was associated with in the highest patency rate (84.6%) during the follow‐up.ConclusionThe recurrence rate of frontal sinus inverted papilloma depends on tumor origin rather than the extent of the tumor. In particular, lesions originating from the frontal sinus lateral to the lamina papyracea recur frequently. Draf III frontal sinusotomy can achieve patent frontal recess allowing active surveillance.Level of EvidenceIV
Normalized solutions for a Schrödinger system with critical Sobolev growth in R3$\mathbb {R}^3$
Authors: Liu Mei‐Qi , Zou Wenming 
Published: December 2023

AbstractWe study the following critical Schrödinger system in :
where , , , and . Any solving such system (for some ) is called the normalized solution in the literature, where the normalization is settled in . We show that this system has a positive ground state for in the case of . For the case of and , we obtain the non‐existence results.
Cough Correlates of Functional Swallow Outcomes in Atypical Parkinsonism
Authors: Mir Michela J. , Childers Justin T. , Wheeler‐Hegland Karen 
Published: December 2023

AbstractBackgroundSwallow and cough impairments lead to aspiration and reduced clearance of aspirate material. Both behaviors are impaired in Parkinson's disease, but it is unknown whether a similar relationship of dysfunction exists in forms of atypical Parkinsonism (APD). Elucidating this association in APD may lead to early, comprehensive airway protection treatment.ObjectivesWe tested the hypotheses that swallow deficits in APD are associated with impaired cough and that airway protective dysfunction is associated with longer disease duration.MethodsSwallowing difficulty was described by 11 participants with APD. Penetration‐Aspiration Scale (PAS) and DIGEST scores for thin liquid trials were extracted from medical records of videofluoroscopic swallow study reports. Voluntary and capsaicin induced‐reflex cough measures of flow, volume, and timing were analyzed.ResultsWhile most participants did not have post‐swallow residue, ~80% received abnormal PAS scores and reported swallowing difficulty. Those with abnormal PAS scores had lower voluntary cough expired volume (P = 0.037; mean rank difference = 5.0); lower reflex inspiratory flow rate (P = 0.034; mean rank difference = 5.5); and longer reflex expiratory flow rise time (P = 0.034; mean rank difference = 5.5). Higher PAS scores and reduced reflex cough volume acceleration were significantly correlated (r = −0.63; P = 0.04) and longer disease duration predicted larger voluntary cough expired volume (R2 = 0.72) and longer flow rise times (R2 = 0.47).ConclusionsAs swallow safety worsens, so might the ability to clear the airways with effective cough in in APD; particularly with longer disease duration. Assessing cough in conjunction with swallowing is important for informing airway protection treatment plans in APD.
Novel mutation in the NDP gene associated with Norrie disease in a Chinese pedigree
Authors: Jiang Keke , Wang Shuying , Sun Huixin , Peng Chuanzhi , Li Nan , Li Shuchan , Gao Rongyu , Zhang Jie 
Published: December 2023

AbstractPurposeNorrie disease (ND) is a rare X‐linked recessive disorder characteristic of early childhood blindness. While several mutations in the NDP gene have been reported as causative for ND, the genetic etiology remains unknown for many patients. This study aims to describe a novel mutation and explore the clinical manifestations in a Chinese family with two affected males.MethodsExome sequencing (ES) was employed to identify the causative gene in a four‐generation pedigree. Sanger sequencing was subsequently utilized to validate the mutation detected by ES in additional family members. Ophthalmologic examination and diagnostic imaging relevant to ND were conducted.ResultsThe proband (IV:2), an 8‐month‐old male infant, presented with binocular retinal detachment. DNA sequencing revealed a novel heterozygous missense mutation (c.174G>C) within the NDP gene in the proband. This mutation affected highly conserved residues and was predicted to disrupt the normal protein structure. Furthermore, the variant co‐segregated with the disease phenotypes within the family.ConclusionsOur findings identified a novel missense mutation in the NDP gene associated with Norrie disease in China, expanding the mutation spectrum associated with ND. This discovery holds diagnostic, prognostic, and genetic counseling implications for affected individuals.
Engineering Nannochloropsis oceanica for the production of diterpenoid compounds
Authors: Du Zhi‐Yan , Bhat Wajid W. , Poliner Eric , Johnson Sean , Bertucci Conor , Farre Eva , Hamberger Bjoern 
Published: December 2023

AbstractPhotosynthetic microalgae like Nannochloropsis hold enormous potential as sustainable, light‐driven biofactories for the production of high‐value natural products such as terpenoids. Nannochloropsis oceanica is distinguished as a particularly robust host with extensive genomic and transgenic resources available. Its capacity to grow in wastewater, brackish, and sea waters, coupled with advances in microalgal metabolic engineering, genome editing, and synthetic biology, provides an excellent opportunity. In the present work, we demonstrate how N. oceanica can be engineered to produce the diterpene casbene—an important intermediate in the biosynthesis of pharmacologically relevant macrocyclic diterpenoids. Casbene accumulated after stably expressing and targeting the casbene synthase from Daphne genkwa (DgTPS1) to the algal chloroplast. The engineered strains yielded production titers of up to 0.12 mg g−1 total dry cell weight (DCW) casbene. Heterologous overexpression and chloroplast targeting of two upstream rate‐limiting enzymes in the 2‐C‐methyl‐
d‐erythritol 4‐phosphate pathway, Coleus forskohlii 1‐deoxy‐
d‐xylulose‐5‐phosphate synthase and geranylgeranyl diphosphate synthase genes, further enhanced the yield of casbene to a titer up to 1.80 mg g−1 DCW. The results presented here form a basis for further development and production of complex plant diterpenoids in microalgae.
Existence of weak solutions for Kirchhoff type double‐phase problem in ℝ
Authors: Arora Anupma , Dwivedi Gaurav 
Published: December 2023

This article aims to study the existence of weak solutions for the Kirchhoff type double‐phase problem
imagewhere
and
is a real parameter. The main distinctive feature of this problem lies in the second nonlinearity on the right‐hand side, which can be in the supercritical. Additionally, we encounter the Kirchhoff term, which might become zero at the origin. By imposing certain assumptions, we establish the existence and multiplicity results.
Role of non‐chromosomal birth defects on the risk of developing childhood Hodgkin lymphoma: A Children's Oncology Group study
Authors: Peckham‐Gregory Erin C. , Boff Lucas Maschietto , Schraw Jeremy M. , Spector Logan G. , Linabery Amy M. , Erhardt Erik B. , Ribeiro Karina B. , Allen Carl E. , Scheurer Michael E. , Lupo Philip J. 
Published: December 2023

AbstractBackgroundNon‐chromosomal birth defects are an important risk factor for several childhood cancers. However, these associations are less clear for Hodgkin lymphoma (HL). Therefore, we sought to more fully elucidate the association between non‐chromosomal birth defects and HL risk.ProcedureInformation on cases (n = 517) diagnosed with HL (ages of 0–14) at Children's Oncology Group Institutions for the period of 1989–2003 was obtained. Control children without a history of cancer (n = 784) were identified using random digit dialing and individually matched to cases on sex, race/ethnicity, age, and geographic location. Parents completed comprehensive interviews and answered questions including whether their child had been born with a non‐chromosomal birth defect. To test the association between birth defects and HL risk, conditional logistic regression was applied to generate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).ResultsChildren born with any non‐chromosomal birth defect were not more likely to be diagnosed with HL at 0–14 years of age (aOR: 0.91; 95% CI: 0.69–1.21). No associations were detected between major or minor birth defects and HL (aOR: 1.34; 95% CI: 0.67–2.67 and aOR: 0.88; 95% CI: 0.57–1.34, respectively). Similarly, no association was observed for children born with any birth defect and EBV‐positive HL (aOR: 0.57; 95% CI: 0.25–1.26).ConclusionsPrevious assessments of HL in children with non‐chromosomal birth defects have been limited. Using data from the largest case–control study of HL in those <15 years of age, we did not observe strong associations between being born with a birth defect and HL risk.
Multiscale modeling of hyperviscoelastic behavior of particulate rubber composites based on hybrid silica/carbon black filler system
Authors: Barghamadi Mohammad , Ghoreishy Mir Hamid Reza , Karrabi Mohammad , Naderi Ghasem 
Published: December 2023

AbstractThe present research outlines the novel finite element analysis of green tire tread compounds based on solution styrene‐butadiene rubber/butadiene rubber (SSBR/BR) reinforced with a hybrid silica/carbon black filler system. For this purpose, a series of micromodels using representative volume elements (RVEs) were developed. The silica/carbon black ratio with a constant value of the reinforcement and considering periodic boundary conditions (PBCs) were established. The distribution of the reinforcing fillers in the matrix was inspired by transmission electron microscope (TEM) micrographs. A nonlinear hyperviscoelastic model was considered for the matrix and interphase zones and a linear elastic model for the reinforcement phase to predict the dissipation behavior at a moderate to high strain regime. To confirm the accuracy of the proposed model, the RVEs of hybrid systems were simulated and then compared with experimental data. The results showed that the proposed model is capable to predict the mechanical properties of rubber compounds. The presence of agglomerated fillers resulted in an increase in the dissipation behavior. This was confirmed by rubber process analyzer (RPA) and dynamic mechanical thermal analysis (DMTA) results.Highlights
Rubber compounds based on SSBR/BR reinforced with silica and/or carbon black were prepared by the melt mixing method.
A multi‐scale finite element analysis of the particulate composites was developed using RVE.
The distribution of reinforcing fillers in the matrix was inspired by TEM.
The prediction of the stress–strain behavior of the hybrid composites was confirmed by the results of tensile tests.
The simulated dissipation behavior of the composites was compared with RPA and DMTA analyses.
Potential‐induced degradation in bifacial silicon heterojunction solar modules: Insights and mitigation strategies
Authors: Arriaga Arruti Olatz , Gnocchi Luca , Jeangros Quentin , Ballif Christophe , Virtuani Alessandro 
Published: December 2023

AbstractPotential‐induced degradation (PID) may be a serious concern in photovoltaic (PV) modules and plants, particularly when approaching high system voltages (1500+ V). Here, we investigate PID occurring in bifacial rear‐emitter silicon heterojunction (SHJ) solar cells encapsulated in a glass/glass (G/G) module configuration with ethylene vinyl acetate (EVA) as an encapsulant. PID testing was performed at 85°C in 85% relative humidity (RH), and the solar cells were subjected to −1 kV and +1 kV for up to 800 h. SHJ cells were found to degrade when subjected to −1 kV, and to a lesser extent when left unbiased in damp heat (DH) conditions, while the application of +1 kV prevented degradation. Although prone to PID after extended test durations, the SHJ mini‐modules investigated in this study noticeably passed the industry standard (IEC 61215:2021) PID test of 96 h. The degradation was primarily characterized by losses in short‐circuit current (ISC) at the front side, followed by fill factor (FF) and open‐circuit voltage (VOC). A cross‐sectional transmission electronic microscopy analysis of the laminates subjected to −1 kV highlighted a transport of sodium (Na) through the transparent conductive oxide (TCO), reaching the amorphous Si/TCO interface. The samples tested in DH conditions and with positive PID test conditions did not exhibit such a migration of Na. To account for these observations, we updated a previously proposed model describing the sensitivity of SHJ cells to water. In our degradation model, moisture in the module corrodes the glass, creating sodium hydroxide (NaOH) that then percolate through the EVA before reaching the SHJ cell. The application of a high negative bias amplifies the previous mechanism by increasing the availability of Na+ and also enhances the drift of Na+ through the EVA to the cell. Finally, we demonstrate that PID can be mitigated or suppressed at the module level by using a high‐volume resistivity encapsulant with a low water vapor transmission rate (WVTR) or by encapsulating SHJ solar cells in a configuration impermeable to water (e.g., using an edge sealant).
Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced rectal injury
Authors: Zhang Hui , Zhang Zhen , Yuan Shuanghu 
Published: December 2023

AbstractAlthough radiotherapy plays an important role in the treatment of cancer, it may have negative effects in some individuals. Rectal injury is a common adverse effect of abdominal and pelvic radiotherapy. This injury is caused by administering radiation to the abdomen. Appropriate treatment techniques can be determined if doctors have a better understanding of the incidence, risk factors, and clinical symptoms of radiation‐induced rectal injuries. Studies on the underlying pathophysiology of radiation‐induced rectal injury may aid in the development of effective treatment and prevention strategies. The implementation of efficient preventive measures can improve the quality of life of patients with cancer and make it easier for them to complete their treatment. Therefore, comprehensive and accurate assessments are crucial for developing holistic and individualized treatment plans for patients who have already developed symptoms, with early intervention being a priority.
Red shell‐ high risk normal tissue in stereotactic radiosurgery
Authors: Yang Jun , Qi Weihua , Wang Lei , Lu Qiuxia , Han Liangfu , Wang Brian , Yan Weisi 
Published: December 2023

AbstractDue to the ablative nature of high prescription in Stereotactic Radiosurgery or stereotactic body radiation therapy (SRS/SBRT), the normal tissue surrounding the CTV receives the dose higher than tissue's dose constraint. A concept of Red Shell is proposed to define and quantify these tissue damaged in SBRT, using biological equivalent dose (BED) concept. The combination of biological factors and physics factors, including serial and parallel organ, dose gradient, dose distribution and fractionations, are further discussed to interpret the clinical meaning of Red Shell. This concept can also help planner to improve the optimization in planning process.
Foliar application of glycine‐functionalized nanopesticides for effective prevention and control of root‐knot nematodes via a targeted delivery strategy
Authors: Zhong Ximing , Su Guofeng , Hao Li , Chen Huayao , Li Chao , Xu Hua , Zhou Hongjun , Zhou Xinhua 
Published: December 2023

AbstractBACKGROUNDRoot‐knot nematodes (RKNs) are the highly damaging pests for various crops, and the prevalence of RKNs has posed serious threats to worldwide agricultural harvest, severely affecting global food security and ecosystem health. Traditional pesticide systems on controlling RKNs generally cause environmental hazards and phytotoxicity due to the excessive use of pesticides resulted from low utilization efficiency. And effective approaches with biosafe and efficient features are highly demanded to break away from the dilemma caused by RKNs.RESULTSIn this research, a nanopesticide system with root‐targeted delivery function was developed to achieve effective prevention and control of RKNs. The nanocarriers (MSN‐KH560‐Gly) and the obtained nanopesticides (EB@MSN‐KH560‐Gly) were proved to be biosafe. Also, this nanopesticide system demonstrated sustained release behavior. The grafting of glycine (Gly) significantly improved the pesticide contents translocating to cucumber roots (about 304.7%). Besides, such root‐targeted delivery function resulted in no root nodule in cucumber plants after the foliar application of these nanopesticides (prevention rate of 100%). In addition, the root nodule numbers of the infected cucumber plants decreased by 71.67%.CONCLUSIONFoliar application of these Gly‐functionalized nanopesticides achieved effective prevention and control of RKNs due to the root‐targeted delivery property inherent in this nanopesticide system, and such root‐targeted delivery strategy opens a novel and efficient method to protect crops from RKN invasion and thus facilitates the development of sustainable agriculture. © 2023 Society of Chemical Industry.
Workflows for detecting fungicide resistance in net form and spot form net blotch pathogens
Authors: Knight Noel L. , Adhikari Kul C. , Dodhia Kejal N. , Mair Wesley J. , Lopez‐Ruiz Francisco J. 
Published: December 2023

AbstractBACKGROUNDFungicide resistance in Pyrenophora teres f. maculata and P. teres f. teres has become an important disease management issue. Control of the associated barley foliar diseases, spot form and net form net blotch, respectively, relies on three major groups of fungicides, demethylation inhibitors (DMIs), succinate dehydrogenase inhibitors (SDHIs) and quinone outside inhibitors (QoIs). However, resistance has been reported for the DMI and SDHI fungicides in Australia. To enhance detection of different resistance levels, phenotyping and genotyping workflows were designed.RESULTSThe phenotyping workflow generated cultures directly from lesions and compared growth on discriminatory doses of tebuconazole (DMI) and fluxapyroxad (SDHI). Genotyping real‐time polymerase chain reaction (PCR) assays were based on alleles associated with sensitivity or resistance to the DMI and SDHI fungicides. These workflows were applied to spot form and net form net blotch collections from 2019 consisting predominantly of P. teres f. teres from South Australia and P. teres f. maculata from Western Australia. For South Australia the Cyp51A L489‐3 and SdhC‐R134 alleles, associated with resistance to tebuconazole and fluxapyroxad, respectively, were the most prevalent. These alleles were frequently found in single isolates with dual resistance. This study also reports the first detection of a 134 base pair insertion located at position‐66 (PtTi‐6) in the Cyp51A promoter of P. teres f. maculata from South Australia. For Western Australia, the PtTi‐1 insertion was the most common allele associated with resistance to tebuconazole.CONCLUSIONThe workflow and PCR assays designed in this study have been demonstrated to efficiently screen P. teres collections for both phenotypic and genetic resistance to DMI and SDHI fungicides. The distribution of reduced sensitivity and resistance to DMI and SDHI fungicides varied between regions in south‐western Australia, suggesting the emergence of resistance was impacted by both local pathogen populations and disease management programmes. The knowledge of fungicide resistance in regional P. teres collections will be important for informing appropriate management strategies. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
UV‐LASER adjuvant–surfactant‐facilitated delivery of mobile dsRNA to tomato plant vasculature and evidence of biological activity by gene knockdown in the potato psyllid
Authors: Thakre Neha , Carver Megan , Paredes‐Montero Jorge R , Mondal Mosharrof , Hu Jiahuai , Saberi Esmaeil , Ponvert Nathaniel , Qureshi Jawwad A , Brown Judith K 
Published: December 2023

AbstractBACKGROUNDDouble‐stranded RNA (dsRNA) biopesticides are of interest for the abatement of insect vectors of pathogenic bacteria such as ‘Candidatus Liberibacter’, which infects both its psyllid and plant hosts. Silencing of genes essential for psyllids, or for Liberibacter, is anticipated to lead to mortality or impeded bacterial multiplication. Foliar delivery is preferred for biopesticide application; however, the cuticle impedes dsRNA penetration into the vasculature. Here, conditions were established for wounding tomato leaves using ultraviolet light amplification by stimulated emissions of radiation (UV‐LASER) to promote dsRNA penetration into leaves and vasculature.RESULTSUV‐LASER treatment with application of select adjuvants/surfactants resulted in vascular delivery of 100‐, 300‐ and 600‐bp dsRNAs that, in general, were correlated with size. The 100‐bp dsRNA required no pretreatment, whereas 300‐ and 600‐bp dsRNAs entered the vasculature after UV‐LASER treatment only and UV‐LASER adjuvant/surfactant treatment, respectively. Of six adjuvant/surfactants evaluated, plant‐derived oil combined with an anionic organosilicon compound performed most optimally. Localization of dsRNAs in the tomato vasculature was documented using fluorometry and fluorescence confocal microscopy. The biological activity of in planta‐delivered dsRNA (200–250 bp) was determined by feeding third‐instar psyllids on tomato leaves post UV‐LASER adjuvant/surfactant treatment, with or without psyllid cdc42‐ and gelsolin dsRNAs. Gene knockdown was quantified by quantitative, real‐time polymerase chain reaction with reverse transcription (RT–qPCR) amplification. At 10 days post the ingestion‐access period, knockdown of cdc42 and gelsolin expression was 61% and 56%, respectively, indicating that the dsRNAs delivered to the tomato vasculature were mobile and biologically active.CONCLUSIONResults indicated that UV‐LASER adjuvant/surfactant treatments facilitated the delivery of mobile, biologically active dsRNA molecules to the plant vasculature. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.