bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular effects of intermittent stress on primary feline uroepithelial cell culture as an in vitro model of feline idiopathic cystitis
Authors: Hatala Patrícia , Sebők Csilla , Mackei Máté , Kárpáti Karina , Gálfi Péter , Neogrády Zsuzsanna , Mátis Gábor 
Published: November 2023

IntroductionThe most common cause of feline lower urinary tract disease (FLUDT) is feline idiopathic cystitis (FIC), which is a complex multifactorial disease with symptoms including stranguria, dysuria, hematuria, and pain during urination. The development of these symptoms is often triggered by stress, and in case of chronic stress, these symptoms will many times return. One of the most important stress hormones in the pathogenesis of FIC is norepinephrine (NE), as persistently elevated level of this hormone can be measured in the blood of cats with FIC. However, it is not well understood if recurrently elevated level of NE has any direct effect on urinary bladder, therefore the aim of this study was to investigate the molecular effects of intermittent NE exposure on feline primary uroepithelial cell culture.MethodsPrimary uroepithelial cells were gained from the mucosa of the bladder of a euthanized cat, and were cultured for 6 days, then they were exposed to 10, 100, and 1,000 μM NE treatment for 3 × 1 h, including a 1 h long regeneration period between exposures.ResultsNE was able to trigger pro-inflammatory response and oxidative stress in the uroepithelial cells by increasing the level of stromal cell derived factor 1 (SDF-1) and H2O2in cell culture media. In addition, NE increased the permeability of the uroepithelium, since decreased glycosaminoglycan (GAG) concentration, tight junction protein claudin-4 content, and TER values were measured after the NE treatments.DiscussionBased on these results it can be concluded that recurrent stress mimicked by 3×1 h NE treatment has a direct molecular effect on the uroepithelial cells, which leads to inflammatory response, oxidative stress and decreased barrier function of the uroepithelium. Therefore, intermittent release of NE may have an important role in the pathogenesis of FIC and the results of this study may contribute to a better understanding of the development of this illness.
Sleep disturbance in people living with dementia or mild cognitive impairment: a realist review of general practice
Authors: Aryankhesal Aidin , Blake Jessica , Wong Geoff , Megson Molly , Briscoe Simon , Allan Louise , Broomfield Niall M , Eastwood Zenahrai , Greene Leanne , Hilton Andrea , Killett Anne , Lazar Alpar S , Litherland Rachael , Livingston Gill , Maidment Ian , Reeve Joanne , Rook George , Scott Sion , Um Jinpil , van Horik Jayden , Fox Chris 
Published: November 2023

BackgroundSleep disturbance is a prevalent condition among people living with dementia (PLwD) or mild cognitive impairment (MCI). Its assessment and management within primary care is complex because of the comorbidities, older age, and cognitive impairment typical of this patient group.AimTo explore how primary care clinicians assess, understand, and manage sleep disturbance for PLwD or MCI; if and why such initiatives work; and how people and their carers experience sleep disturbance and its treatment.Design and settingA realist review of existing literature conducted in 2022.MethodSix bibliographic databases were searched. Context–mechanism–outcome configurations (CMOCs) were developed and refined.ResultsIn total, 60 records were included from 1869 retrieved hits and 19 CMOCs were developed. Low awareness of and confidence in the treatment of sleep disturbance among primary care clinicians and patients, combined with time and resource constraints, meant that identifying sleep disturbance was difficult and not prioritised. Medication was perceived by clinicians and patients as the primary management tool, resulting in inappropriate or long-term prescription. Rigid nursing routines in care homes were reportedly not conducive to good-quality sleep.ConclusionIn primary care, sleep disturbance among PLwD or MCI is not adequately addressed. Over-reliance on medication, underutilisation of non-pharmacological strategies, and inflexible care home routines were reported as a result of low confidence in sleep management and resource constraints. This does not constitute effective and person-centred care. Future work should consider ways to tailor the assessment and management of sleep disturbance to the needs of individuals and their informal carers without overstretching services.
Influencing Purchasing Decisions: The Interplay of Pricing and Product Quality for Garnier Facial Cleanser
Authors: Christianingrum Christianingrum 
Published: November 2023

The aim of this research is to determine the influence of price and product quality on purchase decisions for Garnier products. This study is a quantitative descriptive research using multiple linear regression analysis with a sample of 100 respondents from the Pangkalpinang city community, selected through purposive sampling. The research results indicate that price has a positive and significant effect on purchase decisions; product quality has a positive and significant effect on purchase decisions; and both price and product quality have a positive and significant effect on purchase decisions. The implications of this research are that companies need to understand that product quality and price are factors influencing purchase decisions. In this context, Garnier Company should develop more efficient and effective ways to compete with other companies, ensuring that purchase decisions are optimized.
Keywords: Pricing; Product Quality; Buying Decision; Garnier; Pangkalpinang
PENGARUH KONSENTRASI DARAH DOMBA DAN WAKTU INKUBASI TERHADAP PERTUMBUHAN Streptococcus pneumoniae
Authors: Kusumawati Mutianingrum , Kurniati Iis , Dermawan Asep , Wahyuni Yeni , Setiaputri Irmawanty 
Published: November 2023

Streptococcus pneumoniae (S. pneumoniae) secara mikroskopis Gram positif berbentuk kokus berpasangan, mempunyai kapsul polisakarida, bersifat patogen menyebabkan infeksi pneumonia, bakteriemia, meningitis, dan otitis media akut. Pemeriksaan S. pneumoniae tumbuh pada media yang diperkaya seperti agar darah. Tujuan penelitian ini untuk mengetahui konsentrasi darah dan waktu inkubasi yang optimum untuk pertumbuhan S. pneumoniae. Penelitian ini menggunakan metode kuasi eksperimen dengan membandingkan konsentrasi darah 7%, 9% dan 12% dengan kelompok kontrol 5% yang diinkubasi pada 24 jam dan 48 jam. Diamati jumlah koloni, diameter koloni dan sifat alfa-hemolisis. Data yang diperoleh diuji statistik dengan ANOVA. Hasil penelitian: Uji homogenitas keseluruhan nilai p ≥ 0.050. Hasil analisis secara statistik perbedaan jumlah S. pneumoniae berdasarkan konsentrasi dan waktu inkubasi diperoleh nilai F hitung 0,194 dan nilai signifikansi 0,900 lebih besar dari taraf signifikansi 0,050, sehingga dapat disimpulkan bahwa tidak ada perbedaan Jumlah S. pneumoniae. Perbedaan diameter koloni S. pneumoniae berdasarkan konsentrasi dan waktu inkubasi diperoleh nilai F hitung 5,916 dan nilai signifikansi 0,002 lebih kecil dari taraf signifikansi 0,050, yang artinya dapat disimpulkan bahwa ada perbedaan diameter koloni S. pneumoniae. Kesimpulan: Berdasarkan uji statistik, menunjukkan bahwa konsentrasi darah yang optimum untuk pertumbuhan S. pneumoniae adalah 12%, dan waktu inkubasi yang optimum adalah 48 jam.
Evaluation of electrical properties in anodized n-GaN grown on sapphire substrates at different anodization voltages
Authors: Kamio Gaku , Fujioka Hiroshi , Maeda Narihiko 
Published: November 2023

Abstract
n-GaN grown on sapphire substrates was anodized in an electrolyte solution at different voltages (2 and 4 V) for 3600 s, and the electrical properties of the anodized n-GaN were evaluated. The resistivity of the sample anodized at 2 V increased by a factor of 2.4 at RT, and that of the sample anodized at 4 V increased by a factor of 76 at RT The analysis of temperature dependent Hall effect measurements revealed that anodization changes original donor levels and/or generates energy levels depending on anodization voltages. Anodization has a possibility to transform GaN into GaON-like materials.
Photo-induced bending of chalcogenide glass fiber
Authors: Saitoh Akira , Ishibashi Yukihide , Wada Masaki , Mitsui Kazuki , Tanaka Keiji 
Published: November 2023

Abstract
Optical fibers of a typical chalcogenide glass, As2S3, can be sharply bent only by sideward irradiation of polarized light. The bending direction depends on the polarization; the fiber bends in the forward/backward directions of light propagation for bandgap light that is linearly-polarized orthogonal/parallel to the fiber axis. A reciprocity law between the intensity and the exposure time holds, which suggests that thermal effects are irrelevant. Alternatively, the bending appears to arise from photo-induced optomechanical forces and fluidity. This phenomenon could be developed to a photo-manipulation method of chalcogenide-glass fibers, promising for all-optical switching/modulation devices working at infrared wavelengths.
EFFECTIVENESS OF COUGH ASSIST IN THE EXTUBATION OF ADULT PATIENTS: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Montigiani Giulia , Papi Davide , Proietti Lorenzo , Meucci Beatrice , Taddei Mara , Bucciardini Luca , Di Bari Mauro 
Published: November 2023

In Intensive Care Unit (ICU), failure of extubation, resulting in the need for reintubation, mayoccur in 2-25% of Patients undergoing extubation[1].
The purpose of this review and meta-analysiswas to determine the effectiveness of cough assist in improving success rates of extubation compared with standard treatment.
Inclusion criteria were; Randomized Control Trials, which compared cough assist and conventional therapy in adult population in intensive care unit whith conventional therapy only. Outcomes representing the efficacy of the cough assist were: quantity and quality of secretions (weight, volume, and density), number of reintubation, indices of thoraco-pulmonary function.
The search string produced 764 studies, and only 5 studies eligible for review. Overall, a total of 331 participants were enrolled in the five studies selected.
Of the meta-analyzed outcomes, the calculation of the effect size for the weight of secretions is the one that gave the best results, while no statistical difference was found in the other outcomes. In none of the meta-analysis studies were observed adverse effects in the use of in-exsufflator.
Our systematically review edsuggest sthatcough assist might be feasible and effective in patients intubated in ICU, but studies with larger sample sizes and well-defined outcomes are still required to obtain conclusive evidence.
ANALISIS PENGENDALIAN PERSEDIAAN BAHAN BAKU JERAMI UNTUK PRODUKSI JAMUR CHAMPIGNON DENGAN MENGGUNAKAN METODE ECONOMIC ORDER QUANTITY (EOQ)
Authors: Shoolihah Labiibatish , Suntoro Suntoro , Ariffien Afferdhy 
Published: November 2023

Dunia pangan dikala pandemi sangatlah penting menimbulkan tantangan yang tidak biasa dan belum pernah terjadi sebelumnya bagi otoritas yang bertanggung jawab atas sistem pemantauan keamanan pangan nasional. Pangan merupakan kebutuhan dasar manusia yang diperlukan untuk memenuhi kebutuhan hidup yang sehat, aktif dan produktif. Dalam era ketatnya persaingan industri pangan ini, pengendalian persediaan bahan baku jerami untuk produksi jamur champignon di PT. Eka Timur Raya 2 masih mengalami kendala adanya selisih bahan baku jerami yang diakibatkan antara permintaan perusahaan dengan jerami yang didatangkan oleh supplier tidak sesuai dikarenakan cuaca dan cara pengeringan yang mengakibatkan selisih kadar air jerami, sehingga terjadi ketidaksesuaian persediaan bahan baku jerami di gudang. Kekurangan bahan baku pembuatan jamur champighnon disetiap tahun, yang berimbas menurunnya panen jamur yang mengakibatkan kehilangan penjualan.
Penelitian ini bersifat kuantitatif diperoleh dari dokumen atau arsip PT. Eka Timur Raya 2. Sedangkan data yang bersifat kualitatif diperoleh dari wawancara, pengamatan dan studi secara langsung di lapangan. Hasil dari penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara perhitungan konvensional perusahaan dengan metode Economic Order Quantity (EOQ) yang bisa dilakukan pengehematan sebesar 7,863.37 kg dalam sekali pemesanan dengan penghematan biaya sebesar Rp. 28,195,872 dengan beberapa faktor untuk meminimalisir jumlah persediaan bahan baku jerami dan mengoptimalkan biaya persediaan bahan baku jerami dibutuhkan frekuensi sebanyak 12 kali pemesanan dengan jumlah safety stock sebesar 7,346.7 kg dan pemesanan kembali (reorder point) sebesar 571.41 kg. Hasil dari analisis pemesanan dapat dilakukan pada musim kemarau yang terjadi di bulan Juni, Juli, Agustus. Untuk menghindari kadar air yang berlebih dapat dilakukan pemesanan bahan baku dalam 3 bulan yang disarankan. Dapat dibagi 2 kali pemesanan dalam 1 bulannya sehingga memperoleh hasil yang optimum.
Kata kunci: Pangan, Jerami, Pengendalian Persediaan, Economic Order Quantity
PERANCANGAN SISTEM INFORMASI E-OFFICE BERBASIS WEB DENGAN MENGGUNAKAN METODE RAD
Authors: Supono Supono , Manik Okta Agnes Lady Agatha , Choldun Ibnu 
Published: November 2023

E-Office didesain dengan tujuan untuk membantu mengatasi perpindahan dokumen yang mendukung terjadinya berbagai aktivitas dalam sebuah organisasi Fitur yang terdapat dalam office meliputi: user interface, alur dokumen, informasi dokumen, fasilitas pencarian, pelacakan dokumen fisik, fasilitas catatan elektronik, tautan file dan dokumen serta penjadwalan. Proses bisnis PT Pos Indonesia saat ini Setiap kegiatan masih dilakukan secara manual berupa kertas, tinta dan printer, serta penyimpanan dokumen masih berbentuk fisik di sebuah tempat (lemari penyimpanan). Oleh karena itu dibutuhkan sebuah sistem informasi yang dapat melakukan dan membantu kegiatan monitoring.
Dalam pembangunan sistem ini metode pendekatan yang digunakan yaitu berorientasi objek dengan metodologi pengembangan sistem yang digunakan adalah model RAD. Adapun tools pendukung yang digunakan untuk melakukan perancangan sistem informasi e-office ini adalah BPMN yang digunakan untuk memodelkan sistem proses bisnis yang sedang berjalan. Dalam perancangan sistem ini tools yang digunakan untuk menggambarkan proses yang akan dirancang dan database sistem yang dirancang adalah UML (Unified Modelling Language).
Hasil akhir dari kegiatan ini yakni berupa laporan perancangan sistem informasi e-office berbasis web yang terdiri dari fitur, kelola user, kelola jadwal monitoring, kelola surat tugas dan kelola laporan monitoring. Dengan adanya perancangan sistem informasi yang dibuat diharapkan dapat mempermudah dalam pengelolaan proses e-office dalam proses monitoring pada divisi Tanggung jawab Sosial dan Lingkungan (TJSL) PT Pos Indonesia (Persero).
The Health System Services and Insurance Affects Welfare and Socio-Economic Growth of a Country
Authors: Rexha Bahri , Havolli Ganimete 
Published: November 2023

This paper focuses on the Health System Services, and how affects welfare and socio-economic growth, as an important sector to improve the socio-economic well-being of a developing country such as Kosovo. This study also provides key recommendations of some important policies to be undertaken by the government to improve the Health System Services with the aim for increasing social welfare and socio-economic growth of the country. Some of the different types of government policies and programs have been put in place reducing the Burden of Injury, to improve the health of the population. (Ganguli, I; Grawford, M L; Usadi, B; Mulligan, K L; O'Malley, A J; Yang, C W; Fisher, E S; Morden, N E;, 2023). In our paper we focused on secondary quantitative data collection. The data were provided by the annual health services report for 2022, Pristina Municipality related to the Family Medical Centers “FMC", for 2022. In our study we’ve used the descriptive method, and through tables and charts we’ve provided a comparative analysis, based on some statistics which are expressed in percentage (%) (Sejdiu, Rexha , & Deda, 2023). However, the main purpose is to show the employment structure of the Family Medical Centers "FMC", in Kosovo for 2022, according to the sectors: Primary Health Care and Dental Polyclinic.

Received: 29 July 2023 / Accepted: 19 October 2023 / Published: 5 November 2023
IDENTIFIKASI SIFAT KUALITATIF DAN KUANTITATIF HASIL SILANGAN SAPI PESISIR DAN FRIESIAN HOLSTEIN (FH)
Authors: Putri Oktavially  , Afriani Tinda , Jaswandi  
Published: November 2023

ABSTRAK
Penelitian ini bertujuan untuk mengidentifikasi karakteristik sifat kualitatif dan kuantitatif sapi silangan sapi Pesisir dan sapi Friesian Holstein (FH). Penelitian menggunakan 60 ekor sapi silangan sapi Pesisir dan sapi Friesian Holstein (FH). Metode Penelitian yang digunakan adalah metode berupa pengamatan dan pengukuran langsung dilapangan. Sifat kualitatif yang diamati adalah warna bulu, warna moncong, warna lingkar mata, tanduk dan gelambir. Hasil penelitian antara lain bahwa sifat kualitatif hasil persilangan dengan 3 variasi warna bulu induk, indukan berwan merah bulu merah menghasilkan bulu berwarna paling dominan coklat kemerahan hitam (40,00%), Warna moncong dominan hitam (91,11%). Lingkar mata berwarna dominan hitam (88,89), Muncul tanduk (100,00%) dan bergelamir (100,00%). Indukan berwarna hitam menghasilkan bulu berwarna dominan hitam putih (90,00%), Warna moncong berwarna dominan hitam (91,11%). Warma lingkar mata hitam (100,00%). Muncul tanduk (100,00%) dan bergelambir (100,00%). Indukan berwarna Putih menghasilkan warna bulu dominan berwarna hitam putih (80,00%), Warna moncong hitam (100,00%), warna lingkar mata hitam (100,00%). Muncul tanduk (100,00%) dan bergelambir (100,00%). Ukuran tubuh betina umur 0,3,6 bulan berturut-turut : Panjang Badan (56,49 cm ± 2,65, 76,11 cm ± 4,16, 92,22 cm ± 2,38), Tinggi Pundak (55,76 cm ± 3,90, 75,00 cm ± 3,95, 89,89 cm ± 2,62), Lingkar dada (69,14 cm ± 2,12, 90,32 cm ± 3,67, 100,41 cm ± 1,62), Panjang Kepala (20,41 cm ± 1,36, 22,03 cm ± 1,61, 25,35 cm ± 2,26), Lebar kepala (10,51 cm ± 1,04, 12,32 cm ± 0,97, 13,57 cm ± 1,09), Bobot badan (24,90 cm ± 1,43, 57,38 cm ± 5,69, 85,79 cm ± 3,61). Ukuran tubuh Jantan lebih tinggi dari pada betina.

Kata kunci: Kualitatif, Kuantitatif, Sapi Friesien Holstein (FH) dan Sapi Pesisir
ANALISIS POLA HARGA DAN TREND PROJECTION INPUT DAN OUTPUT AYAM BROILER DI INDONESIA
Authors: Fitrimawati  , Nurhayati  , Indrayani Ida 
Published: November 2023

Harga merupakan unsur penting bagi produsen dan bagi konsumen. Harga dari ayam broiler juga menentukan tingkat kerugian dan keuntungan yang dapat diperoleh pengusaha atau peternak ayam broiler itu sendiri. Harga yang fluktuatif tentu akan menyulitkan prediksi terhadap suatu usaha. Tujuan dari penelitian ini adalah untuk menganalisis pola harga dan trend projection input dan output ayam broiler di Indonesia. Pada penelitian ini dianalisis harga pakan, DOC, dan ayam broiler dari tahun 2017 hingga 2021 untuk dapat menghasilkan pola harga dan memprediksi kecendrungan harga tersebut lima tahun kedepan. Data yang digunakan adalah data sekunder. Berdasarkan hasil penelitian, pola harga pakan, harga DOC dan harga ayam broiler di Indonesia lima tahun terakhir cenderung mengalami kenaikan. Hal yang sama juga diprediksi berlaku kecendrungan kenaikan harga lima tahun kedepan. Oleh karena itu perlu adanya kebijakan yang dapat menjaga kestabilan harga input dan output ayam broiler sehingga dapat melindungi produsen dan konsumen ayam broiler di Indonesia.
Kata kunci: Ayam broiler, Pola Harga, Trend Projection, Indonesia
The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
Authors: Fu Liyan , Xu Lang , Qian Jin , Wu Xiaoli , Wang Zhiying , Wang Hualin , Liu Dan , Deng Fei , Shen Shu 
Published: November 2023

ABSTRACT.
Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV) and Guertu virus (GTV) belong to the severe fever with thrombocytopenia syndrome/Heartland group of genus Bandavirus in the family Phenuiviridae of order Bunyavirales. Severe fever with thrombocytopenia syndrome virus and HRTV, identified from ticks from Asia and America, respectively, are important pathogens causing severe febrile diseases in humans. Guertu virus, closely related to these two viruses, is a potential pathogen, but no confirmed infection has been identified. So far, human-derived neutralizing monoclonal antibodies (mAbs) against SFTSV have been identified as having a great potential to be developed as antivirals; however, there is still a lack of neutralizing mAbs to GTV and HRTV. In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their protective effect could be further evaluated in virus-infected mice. Their differential neutralizing efficiency and specificity further suggested that the three viruses share common mechanisms on the basis of GP functioning, and that HRTV poses a unique mechanism that differs from the other viruses. These findings shed light on developing broad-spectrum antiviral strategies against bandaviruses and promoting an understanding of the bandavirus infection process.
Assessment of Clinical, Histopathological, and Bacteriological Findings in Treated Leprosy Patients with Persistent Skin Lesions: A Retrospective Cohort Study
Authors: Patial Meenakshi , Hanumanthu Vinod , Chhabra Seema , Singh Itu , Chatterjee Debajyoti , Narang Tarun , Dogra Sunil 
Published: November 2023

ABSTRACT.
Since the introduction of multidrug therapy (MDT), various disabilities/morbidities due to leprosy have been prevented. However, there is a subset of patients in whom the skin lesions do not resolve completely or remain unchanged despite a full course of MDT, which is a great source of anxiety to the patient and their family members. Hence, we tried to ascertain the putative causes and risk factors of persistent skin lesions (PSLs) by analyzing the clinical, histopathological, bacteriological, and drug resistance patterns. This is a retrospective, cohort study wherein 35 patients who had PSLs after completion of MDT were included. The majority of the patients were 18 to 30 years of age, with males predominating. Borderline tuberculoid leprosy was the most common clinical spectrum observed (71.4%). The majority had PSLs distributed predominantly over photo-exposed sites (upper limbs > trunk > face). Eight patients (22.8%) had a history of contact with leprosy patients in their family, and six patients (17.1%) had associated comorbidities. Improvement in histopathological parameters such as a decrease in granuloma fraction was observed in 22 patients (62.8%) with PSLs after release from treatment in comparison with baseline. Four patients (11.4%) were noted to have drug resistance (three to rifampicin and one to dapsone). Thus, our study emphasizes that leprosy patients with PSLs after completion of MDT should undergo histopathological evaluation and drug resistance studies.