bluuebunny/crossref_metadata_2025_split huggingface dataset:
Independent Monte Carlo dose calculation identifies single isocenter multi‐target radiosurgery targets most likely to fail pre‐treatment measurement
Authors: Erickson Brett , Cui Yunfeng , Alber Markus , Wang Chunhao , Fang Yin Fang , Kirkpatrick John , Adamson Justus 
Published: January 2024

AbstractPurposeFor individual targets of single isocenter multi‐target (SIMT) Stereotactic radiosurgery (SRS), we assess dose difference between the treatment planning system (TPS) and independent Monte Carlo (MC), and demonstrate persistence into the pre‐treatment Quality Assurance (QA) measurement.MethodsTreatment plans from 31 SIMT SRS patients were recalculated in a series of scenarios designed to investigate sources of discrepancy between TPS and independent MC. Targets with > 5% discrepancy in DMean[Gy] after progressing through all scenarios were measured with SRS MapCHECK. A matched pair analysis was performed comparing SRS MapCHECK results for these targets with matched targets having similar characteristics (volume & distance from isocenter) but no such MC dose discrepancy.ResultsOf 217 targets analyzed, individual target mean dose (DMean[Gy]) fell outside a 5% threshold for 28 and 24 targets before and after removing tissue heterogeneity effects, respectively, while only 5 exceeded the threshold after removing effect of patient geometry (via calculation on StereoPHAN geometry). Significant factors affecting agreement between the TPS and MC included target distance from isocenter (0.83% decrease in DMean[Gy] per 2 cm), volume (0.15% increase per cc), and degree of plan modulation (0.37% increase per 0.01 increase in modulation complexity score). SRS MapCHECK measurement had better agreement with MC than with TPS (2%/1 mm / 10% threshold gamma pass rate (GPR) = 99.4 ± 1.9% vs. 93.1 ± 13.9%, respectively). In the matched pair analysis, targets exceeding 5% for MC versus TPS also had larger discrepancies between TPS and measurement with no GPR (2%/1 mm / 10% threshold) exceeding 90% (71.5% ± 16.1%); whereas GPR was high for matched targets with no such MC versus TPS difference (96.5% ± 3.3%, p = 0.01).ConclusionsIndependent MC complements pre‐treatment QA measurement for SIMT SRS by identifying problematic individual targets prior to pre‐treatment measurement, thus enabling plan modifications earlier in the planning process and guiding selection of targets for pre‐treatment QA measurement.
Decoupling Interfacial Kinetics Realizes 5C Fast Charging of Potassium‐Ion Batteries Using Graphite Anode
Authors: Zhou Wang , Mo Ying , Gao Peng , Wang Kexuan , Ke Jinlong , Liu Zheng , Chen Shi , Liu Jilei 
Published: January 2024

AbstractImproving interfacial kinetics is the key to realizing extreme fast charging (XFC) of graphite‐based potassium ion batteries (PIBs). The electrolyte engineering is commonly used for solid electrolyte interphase (SEI) design. However, this strategy adjusts both ion solvation structure and (de)solvation kinetics simultaneously, thus making it difficult to explicitly reveal the linkage between SEI properties and interfacial kinetics. Herein, the content of inorganic species in preformed SEI on graphite surface is precisely regulated and uncovered its critical role in improving the interfacial kinetics. The charge transfer kinetics on graphite/electrolyte interphase is found to be the rate limitation step upon XFC. Meanwhile, the increased inorganic species in SEI plays a decisive role in optimizing the charge transfer rather than the kinetics of naked K+ crossing SEI. Through unlocking the anodic charge transfer limitation with ultra‐inorganic rich SEI, the graphite//Prussian blue analogs full cells achieve a superior XFC ability (13 min charge to 80%) with a specific capacity of 103 mAh g−1 at 5 C. This work provides a fundamental understanding of the relationship between SEI properties and interfacial kinetics during XFC, which enables the rational design of SEI chemistry for fast‐charging PIBs.
Metastructure “Trap” Coating by Acoustic Confinement Effect for Antibacterial Sonothermal Therapy
Authors: Guan Shiwei , Chen Shuhan , Zhang Xianming , Zhang Haifeng , Liu Xingdan , Hou Zhiyu , Wang Fang , Qian Shi , Zhu Hongqin , Tan Ji , Liu Xuanyong 
Published: January 2024

AbstractAntibacterial sonothermal therapy (ASTT) is attractive for treating implant‐associated infection, which addresses the limitations of poor penetration of photothermal therapy. However, achieving implant surface‐specific ultrasound heating is incredibly challenging. Inspired by the porous acoustic metastructure in noise reduction, the acoustic metastructure would be a new strategy for attaining ASTT. Herein, an “acoustic confinement effect” is proposed to “trap” ultrasound for the metastructure TiO2 porous coating on titanium implants. The metastructure coating accomplishes specific acoustic absorption and efficient acoustic‐to‐thermal conversion, surpassing the non‐specific heating of conventional coatings. The theoretical calculation and experiment of metastructure porous coating prove the acoustic‐to‐thermal conversion mechanism, which is also validated in metastructure porous coatings on medical polyetheretherketone, indicating it is universal. Excitingly, this acoustic metastructure “trap” can capture bacteria and local sonothermal enhancement, exhibiting superior ASTT antibacterial rates (S. aureus, 99.69%; E. coil, 99.58%) at low‐power ultrasound. In addition, the metastructure TiO2 coating mimics human bone and demonstrates outstanding osseointegration. This study sheds substantial light on developing the acoustic responsive surface, broadening a new direction of acoustic metamaterials in medical applications.
Persistent Targeting DNA Nanocarrier Made of 3D Structural Unit Assembled from Only One Basic Multi‐Palindromic Oligonucleotide for Precise Gene Cancer Therapy
Authors: Wu Jingting , Zheng Xiaoqi , Lin Wenqing , Chen Linhuan , Wu Zai‐Sheng 
Published: January 2024

AbstractConstruction of a simple, reconfigurable, and stimuli‐responsive DNA nanocarrier remains a technical challenge. In this contribution, by designing three palindromic fragments, a simplest four‐sticky end‐contained 3D structural unit (PS‐unit) made of two same DNA components is proposed. Via regulating the rotation angle of central longitudinal axis of PS‐unit, the oriented assembly of one‐component spherical architecture is accomplished with high efficiency. Introduction of an aptamer and sticky tail warehouse into one component creates a size‐change‐reversible targeted siRNA delivery nanovehicle. Volume swelling of 20 nm allows one carrier to load 1987 siPLK1s. Once entering cancer cells and responding to glutathione (GSH) stimuli, siPLK1s are almost 100% released and original size of nanovehicle is restored, inhibiting the expression of PLK1 protein and substantially suppressing tumor growth (superior to commercial transfection agents) in tumor‐bearing mice without systemic toxicity.
Electro‐Optical Multiclassification Platform for Minimizing Occasional Inaccuracy in Point‐of‐Care Biomarker Detection
Authors: Dai Changhao , Xiong Huiwen , He Rui , Zhu Chenxin , Li Pintao , Guo Mingquan , Gou Jian , Mei Miaomiao , Kong Derong , Li Qiang , Wee Andrew Thye Shen , Fang Xueen , Kong Jilie , Liu Yunqi , Wei Dacheng 
Published: January 2024

AbstractOn‐site diagnostic tests that accurately identify disease biomarkers lay the foundation for self‐healthcare applications. However, these tests routinely rely on single‐mode signals and suffer from insufficient accuracy, especially for multiplexed point‐of‐care tests (POCTs) within a few minutes. Here, this work develops a dual‐mode multiclassification diagnostic platform that integrates an electrochemiluminescence sensor and a field‐effect transistor sensor in a microfluidic chip. The microfluidic channel guides the testing samples to flow across electro‐optical sensor units, which produce dual‐mode readouts by detecting infectious biomarkers of tuberculosis (TB), human rhinovirus (HRV), and group B streptococcus (GBS). Then, machine‐learning classifiers generate three‐dimensional (3D) hyperplanes to diagnose different diseases. Dual‐mode readouts derived from distinct mechanisms enhance the anti‐interference ability physically, and machine‐learning‐aided diagnosis in high‐dimensional space reduces the occasional inaccuracy mathematically. Clinical validation studies with 501 unprocessed samples indicate that the platform has an accuracy approaching 99%, higher than the 77%–93% accuracy of rapid point‐of‐care testing technologies at 100% statistical power (>150 clinical tests). Moreover, the diagnosis time is 5 min without a trade‐off of accuracy. This work solves the occasional inaccuracy issue of rapid on‐site diagnosis, endowing POCT systems with the same accuracy as laboratory tests and holding unique prospects for complicated scenes of personalized healthcare.
Single Channel Based Interference‐Free and Self‐Powered Human–Machine Interactive Interface Using Eigenfrequency‐Dominant Mechanism
Authors: Ding Sen , Zhao Dazhe , Chen Yongyao , Dai Ziyi , Zhao Qian , Gao Yibo , Zhong Junwen , Luo Jianyi , Zhou Bingpu 
Published: January 2024

AbstractThe recent development of wearable devices is revolutionizing the way of human–machine interaction (HMI). Nowadays, an interactive interface that carries more embedded information is desired to fulfill the increasing demand in era of Internet of Things. However, present approach normally relies on sensor arrays for memory expansion, which inevitably brings the concern of wiring complexity, signal differentiation, power consumption, and miniaturization. Herein, a one‐channel based self‐powered HMI interface, which uses the eigenfrequency of magnetized micropillar (MMP) as identification mechanism, is reported. When manually vibrated, the inherent recovery of the MMP causes a damped oscillation that generates current signals because of Faraday's Law of induction. The time‐to‐frequency conversion explores the MMP‐related eigenfrequency, which provides a specific solution to allocate diverse commands in an interference‐free behavior even with one electric channel. A cylindrical cantilever model is built to regulate the MMP eigenfrequencies via precisely designing the dimensional parameters and material properties. It is shown that using one device and two electrodes, high‐capacity HMI interface can be realized when the magnetic micropillars (MMPs) with different eigenfrequencies have been integrated. This study provides the reference value to design the future HMI system especially for situations that require a more intuitive and intelligent communication experience with high‐memory demand.
Binary Organic Solar Cells with over 19 % Efficiency and Enhanced Morphology Stability Enabled by Asymmetric Acceptors
Authors: Chen Shihao , Zhu Shengtian , Hong Ling , Deng Wanyuan , Zhang Yi , Fu Yuang , Zhong Zuiyi , Dong Minghao , Liu Chunchen , Lu Xinhui , Zhang Kai , Huang Fei 
Published: January 2024

AbstractThe simultaneous improvement of efficiency and stability of organic solar cells (OSCs) for commercialization remains a challenging task. Herein, we designed asymmetric acceptors DT‐C8Cl and DT‐C8BTz with functional haloalkyl chains, in which the halogen atoms could induce noncovalent interactions with heteroatoms like O, S, and Se, etc., thus leading to appropriately manipulated film morphology. Consequently, binary devices based on D18: DT‐C8Cl achieved a champion power conversion efficiency (PCE) of 19.40 %. The higher PCE of D18: DT‐C8Cl could be attributed to the enhanced π–π stacking, improved charge transport, and reduced recombination losses. In addition, the noncovalent interactions induced by haloalkyl chains could effectively suppress unfavorable morphology evolutions and thereby reduce trap density of states, leading to improved thermal and storage stability. Overall, our findings reveal that the rational design of asymmetric acceptors with functional haloalkyl chains is a novel and powerful strategy for simultaneously enhancing the efficiency and stability of OSCs.
A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids
Authors: Shi Chenzhi , Yang Donglei , Ma Xiaowei , Pan Li , Shao Yuanchuan , Arya Gaurav , Ke Yonggang , Zhang Chuan , Wang Fuan , Zuo Xiaolei , Li Min , Wang Pengfei 
Published: January 2024

AbstractNucleic acids in biofluids are emerging biomarkers for the molecular diagnostics of diseases, but their clinical use has been hindered by the lack of sensitive detection assays. Herein, we report the development of a sensitive nucleic acid detection assay named SPOT (sensitive loop‐initiated DNAzyme biosensor for nucleic acid detection) by rationally designing a catalytic DNAzyme of endonuclease capability into a unified one‐stranded allosteric biosensor. SPOT is activated once a nucleic acid target of a specific sequence binds to its allosteric module to enable continuous cleavage of molecular reporters. SPOT provides a highly robust platform for sensitive, convenient and cost‐effective detection of low‐abundance nucleic acids. For clinical validation, we demonstrated that SPOT could detect serum miRNAs for the diagnostics of breast cancer, gastric cancer and prostate cancer. Furthermore, SPOT exhibits potent detection performance over SARS‐CoV‐2 RNA from clinical swabs with high sensitivity and specificity. Finally, SPOT is compatible with point‐of‐care testing modalities such as lateral flow assays. Hence, we envision that SPOT may serve as a robust assay for the sensitive detection of a variety of nucleic acid targets enabling molecular diagnostics in clinics.
Development of extrusion blown films of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) blends for flexible packaging
Authors: Le Delliou Benjamin , Vitrac Olivier , Benihya Anir , Guinault Alain , Domenek Sandra 
Published: January 2024

AbstractPoly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) is a biodegradable polymer with significant potential for use in food packaging. However, its limited melt strength poses a challenge when employing film‐blowing techniques to produce flexible packaging. To overcome this obstacle, we developed blends consisting of 70 wt% PHBV and 30 wt% poly(butylene‐co‐succinate‐co‐adipate) (PBSA). Organic peroxides such as dicumyl peroxide and 2,5‐dimethyl‐2,5‐di‐(tert‐butylperoxy)hexane, were utilized as reactive compatibilizers to enhance the interfacial adhesion between the polymers. Additionally, acetyl tributyl citrate (ATBC) was employed as a plasticizer to improve processability and ductility. The inclusion of organic peroxides resulted in the formation of long‐branched structures, as confirmed by the van‐Gurp‐Palmen plot. The melt flow index decreased from 30 to 9.8 g/10 min without ATBC and 15.5 g/10 min with ATBC. Successful production of blown PHBV/PBSA films was achieved on a pilot scale (bubble height 180 cm). These films exhibited heat‐sealing capability and increased impact strength (7.7 kJ/m2). Moreover, the films maintained a maximum elongation at break of 4% during a 3‐month storage experiment with frozen food. Food safety was assessed through overall migration experiments, and the non‐plasticized films received approval. In conclusion, the compatibilized PHBV/PBSA blends demonstrate great potential as materials for manufacturing film‐blown flexible packaging.
Preparation and smoke suppression mechanism of flame‐retardant PBS composites with BNNS@DOPA
Authors: Zhang Yun , Jiang Zhenlin , Wang Mei , Chen Jiapeng , Wang Baoxiu , Wang Chaosheng , Peng Qifei , Xiong Lulu 
Published: January 2024

AbstractCurrently, the flame‐retardant modification of polybutylene succinate (PBS) is mainly focused on improving flame‐retardant efficiency, ignoring the negative impact of the smoke produced by combustion on the human respiratory tract. To address this problem, PBS composites were prepared by melt blending method in this study. The effect of boron nitride‐grafted DOPO flame retardant (BNNS@DOPA) on flame retardancy and smoke suppression of PBS composites was investigated. Incorporating 3% BNNS@DOPA into PBS composites results in a 90% improvement in thermal conductivity. This resulted in a reduction of the peak heat release rate, total heat release rate, and actual smoke rate to 453.7 kW m−2, 86.3 MJ m−2, and 1035.9 m2, respectively, compared with pure PBS. The latter indicated a decrease of 34.0%, 37.6%, and 51.2%, respectively. Furthermore, the ignition time was extended by 45 s and the limiting oxygen index value increased by 12.5%. This functionalization approach presents a new way to study PBS flame retardancy improvement, consequently boosting its application in fire safety for polymer materials.
Exploring the effects of montmorillonite and halloysite nanotubes on mechanical, optical and barrier properties of poly (butylene adipate‐co‐terephthalate) blown films: Implications for sustainable packaging and food storage
Authors: García‐Carrillo Miguel , González‐Granados Isaac , Hernández‐López Aimeé Alejandra , Espinoza‐Martínez Adriana Berenice 
Published: January 2024

AbstractBiodegradable packaging plastics combining good mechanical properties and low gas permeability is required to avoid environmental and food safety concerns. This study explores the impact of montmorillonite (MMT) and halloysite nanotubes (HNT), on the mechanical, optical, and oxygen permeability of blown film poly (butylene adipate‐co‐terephthalate) (PBAT) composites. The morphology of the films was evaluated by x‐ray diffraction (XRD), differential scanning calorimetry and scanning electron microscopy. Good distribution/dispersion of clays is found in the PBAT‐MMT films. Besides, there is an increase in the crystallinity of PBAT due to the nucleating effect of HNT. Improvement in the tensile strength and elongation at break in the machine direction is obtained up to a clay content of 1.5 vol%. The incorporation of 1.5 vol% of MMT and 1 vol% of HNT leads to a reduction in the oxygen permeability of the PBAT film by 29% and 38% respectively. Furthermore, the films remain transparent regardless of clay content. Finally, the feasibility of the films for food storage is tested in grapes, obtaining extended shelf life. The favorable mechanical, barrier and optical properties of the biodegradable films, along with the scalable production process, make them attractive for application in the storage and preservation of food products.
Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential
Authors: El Kady Wafaa M. , Ayoub Iriny M. , El Mehrate Ahmed K. , Emad Mohamed , Tarek Mohamed , El Gdeily Ahmed , Mohamed El‐Romisaa , Medhat Rana , Mahmoud Omar , Gad Amira M. , Danderawy Alaa M. , Breaka Ola L. , Mosad Nada E. , Gemeaha Safaa M. , Fathallah Noha 
Published: January 2024

AbstractAging and agro‐waste are major challenges. Natural ingredients are preferred in skincare. This study intended to isolate the essential oils (EO) from the leftover peels obtained from three commonly edible Citrus species fruit peels, namely Citrus paradisi (grapefruit), Citrus sinensis (sweet orange), and Citrus deliciosa (mandarin). Gas chromatography/mass spectrometry analysis identified volatile constituents in EO and headspace aroma. Multivariate analysis distinguished between the three species. The antiaging effects of Citrus EO were assessed in vitro and in silico, studying volatile interactions with target enzymes. C. sinensis peels had the highest oil yield, rich in monoterpenes. C. paradisi and C. deliciosa contained sesquiterpenes. Limonene dominated the hydrodistilled EO: 94.50% in C. paradisi, 96.80% in C. sinensis, and 80.66% in C. deliciosa. Unsupervised multivariate analysis of Citrus species revealed that
d‐limonene, γ‐terpinene, and β‐pinene are the key phytochemical markers contributing to their diverse chemical composition. C. paradisi exhibited the highest enzyme inhibitory activity, with IC50 values of 12.82, 27.58, and 18.16 µg/mL for tyrosinase, elastase, and collagenase, respectively. In silico studies showed that the volatiles can inhibit the tested antiaging enzymes. According to these findings, the investigated agro‐waste might slow aging in skin care.
Construction of Synergistic Co/CoO Interface to Enhance Hydrogenation Activity of Ethyl Lactate to 1,2‐Propanediol
Authors: Li Chengyang , Wang Jia , Zhao Jing , Gao Guang , Wu Kuang‐Hsu , Su Bing‐Jian , Chen Jin‐Ming , Xi Yongjie , Huang Zhiwei , Qiao Yan , Li Fuwei 
Published: January 2024

AbstractThe development of effective and stable non‐precious catalysts for hydrogenation of ester to diols remains a challenge. Herein, the catalytic hydrogenation of ethyl lactate (EL) to 1,2‐propanediol (1,2‐PDO) with supported Co catalysts derived from layered double hydroxides (LDHs) is investigated. Catalytic tests reveal that LDH‐derived Co catalysts exhibit the best catalytic performance with 98 % of EL conversion and >99 % of 1,2‐PDO selectivity at mild conditions, compared with other Co catalysts (supported on Al2O3, and TiO2) and LDH‐derived Cu catalysts. Due to the strong interaction among Co and Al matrix, the main composition is metallic Co0 and CoO after reduction at 600 °C. Besides, the catalyst shows good recyclability in the liquid phase hydrogenation. The superior catalytic performance can be attributed to the synergistic effect between Co0 and CoO, in which H2 molecule is activated on Co0 and EL is strongly adsorbed on CoO via hydroxyl groups.
Fault‐tolerant adaptive tracking control for spacecraft attitude with asymptotic convergence
Authors: Yin Yuwan , Ning Xin , Wang Zheng , Xia Dongdong 
Published: January 2024

AbstractIn this paper, we present a novel spacecraft attitude adaptive tracking control strategy that addresses the challenges posed by unknown inertia parameters, bounded unstructured uncertainties, and various actuator faults. To mitigate the adverse effects of these multiple uncertainties, our proposed control algorithm utilizes a simple tracking‐error feedback and compensation term, which only requires two adaptive parameters. This approach ensures asymptotic tracking convergence by employing an infinitely integrable inequality that incorporates saturation functions. As a result, the complexity of controller design and computational burden are significantly reduced. Finally, several numerical simulations are conducted to validate the feasibility and superiority of our proposed controller.
Process development and characterization for integrated continuous bioprocesses—Highlights from N‐mAb
Authors: Brower Kevin , Wiltberger Kelly , Berdugo Claudia , Bosley Allen , Goodrich Elizabeth , Pferdeort Valerie , Schaefer Gene 
Published: January 2024

AbstractThe N‐mAb case study was produced by the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) to support teaching and learning for both industry and to accelerate adoption of advanced manufacturing process technologies such as integrated continuous bioprocesses (ICB) for mAbs. Similar to the A‐mAb case study, N‐mAb presents the evolution of an integrated control strategy, from early clinical through process validation and commercial manufacturing with a focus on elements that are unique to integrated continuous bioprocesses. This publication presents a summary of the process design and characterization chapters to allow a greater focus on the unique elements relevant to that phase of development.