bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the uptake and adaption of targeted implementation interventions for reducing bronchiolitis investigations and therapies
Authors: Robertson Tim , Borland Meredith L. , O'Brien Sharon , Haskell Libby , Babl Franz E. , Dalziel Stuart R. , Tavender Emma 
Published: January 2024

AbstractAimTo understand and evaluate the uptake and local adaptations of proven targeted implementation interventions that have effectively reduced unnecessary investigations and therapies in infants with bronchiolitis within emergency departments.MethodsA multi‐centred, mixed‐methods quality improvement study in four Australian hospitals that provide paediatric emergency and inpatient care from May to December 2021. All hospitals were provided with the same implementation intervention package and training. Real‐time tracking logs of adaptions were completed followed by semi‐structured interviews. Interviews were recorded, transcribed and subsequently coded using FRAME‐IS to further describe the adaptions made.ResultsTracking logs were summarised and data from 12 interviews were compared from participating sites. The intervention resulted in 116 education sessions and a total of 23 adaptations made to educational materials, both content and contextual. Shortening education presentations, addition of bronchiolitis definitions, formatting of materials and novel interventions were the most common modifications. Audit and feedback were completed across all sites with varying utilisation. Targeted teaching was noted to dictate adaptions prior to and during implementation.ConclusionQuantitative and qualitative analysis of clinical ‘real‐world’ adaptations to proven targeted implementation interventions allows invaluable insight for future de‐implementation initiatives and national roll‐out of implementation packages in the ED setting.
Pollination of Chamaepentas nobilis (Rubiaceae) by long‐proboscid hawkmoths in south‐central Africa: Trait mismatching and floral scent chemistry
Authors: Johnson Steven D. 
Published: January 2024

AbstractThe evolution of extremely long (>10 cm) floral tubes in angiosperms is closely linked with adaptation for pollination by long‐proboscid hawkmoths. In most cases, pollen is placed on the head or body of these moths, selecting for floral tubes that match or slightly exceed their proboscis length as this ensures contact with reproductive parts of the flower. However, in the case of Chamaepentas nobilis (Rubiaceae), anthers are inserted inside the c. 12‐cm floral tubes and coat the proboscis of visiting hawkmoths with sticky pollen, meaning that insects with proboscides longer than the floral tube can be effective pollinators, despite trait mismatching. Direct observations and camera trapping on granite outcrops in central Zambia showed that C. nobilis was visited both by Agrius convolvuli (proboscis length c. 13 cm) and Xanthopan morganii (proboscis length c. 17 cm), which are the only moth species in Africa that can access the small amounts of dilute nectar at the base of the floral tube. Pollen on the proboscides of captured hawkmoths was confirmed to originate from C. nobilis. Key floral advertising traits of C. nobilis include early evening anthesis, the highly reflective white limbus, and the evening production of scent dominated by oxygenated aromatic and terpenoid compounds known to elicit antennal responses of A. convolvuli. This study shows that that A. convolvuli and X. morganii share floral resources and jointly pollinate C. nobilis, despite their proboscides differing in length and being mismatched with the corolla tube length.
L‐type amino acid transporter 1 inhibitor JPH203 prevents the growth of cabazitaxel‐resistant prostate cancer by inhibiting cyclin‐dependent kinase activity
Authors: Rii Junryo , Sakamoto Shinichi , Mizokami Atsushi , Xu Minhui , Fujimoto Ayumi , Saito Shinpei , Koike Hidekazu , Tamura Takaaki , Arai Takayuki , Yamada Yasutaka , Goto Yusuke , Sazuka Tomokazu , Imamura Yusuke , Suzuki Kazuhiro , Kanai Yoshikatsu , Anzai Naohiko , Ichikawa Tomohiko 
Published: January 2024

AbstractL‐type amino acid transporter 1 (LAT1, SLC7A5) is an amino acid transporter expressed in various carcinomas, and it is postulated to play an important role in the proliferation of cancer cells through the uptake of essential amino acids. Cabazitaxel is a widely used anticancer drug for treating castration‐resistant prostate cancer (CRPC); however, its effectiveness is lost when cancer cells acquire drug resistance. In this study, we investigated the expression of LAT1 and the effects of a LAT1‐specific inhibitor, JPH203, in cabazitaxel‐resistant prostate cancer cells. LAT1 was more highly expressed in the cabazitaxel‐resistant strains than in the normal strains. Administration of JPH203 inhibited the growth, migration, and invasive ability of cabazitaxel‐resistant strains in vitro. Phosphoproteomics using liquid chromatography‐mass spectrometry to comprehensively investigate changes in phosphorylation due to JPH203 administration revealed that cell cycle‐related pathways were affected by JPH203, and that JPH203 significantly reduced the kinase activity of cyclin‐dependent kinases 1 and 2. Moreover, JPH203 inhibited the proliferation of cabazitaxel‐resistant cells in vivo. Taken together, the present study results suggest that LAT1 might be a valuable therapeutic target in cabazitaxel‐resistant prostate cancer.
Co‐rumination between friends: Considering the roles of outcome expectations, relationship provisions, and perceptions of problems
Authors: Borowski Sarah K. , Rose Amanda J. 
Published: January 2024

AbstractDespite its implications for adjustment, little is known about factors that support co‐rumination in friendships. The current multi‐method, longitudinal study addressed this question with 554 adolescents (Mage = 14.50; 52% girls; 62% White; 31% Black; 7% Asian American) from the Midwestern United States in 2007–2010. Adolescents were observed talking about problems with a friend and reported on their outcome expectations for problem disclosures, relationship provisions during problem talk, and problem perceptions after problem talk. Participants reported on outcome expectations again 9 months later. Results indicate that the positive relationship provisions associated with co‐rumination may outweigh negative problem perceptions in predicting adolescents' outcome expectations for problem disclosures over time. Implications for the potentially reinforcing nature of co‐rumination are discussed.
Too little, too late? Sociological reflections on religious responses to climate crisis
Authors: Norgaard Kari Marie 
Published: January 2024

AbstractAre religious communities better advantaged to mobilize for social change than other institutions and communities and other social spaces? If so, how might they do so? What unique resources can religious communities offer to this effort? Even if there is no set formula to generate climate engagement, are there conditions we can recommend? As one of the few social spaces that might systematically compel collective moral engagement, religious communities and organizations hold the potential to play a key role in societal response. Religious teachings, leaders, and communities have provided individuals the moral conviction to do what is right and the courage to act when one is afraid, and they have offered a microcosm of social networks and social norms that supported social engagement. Not only do religious communities provide a rare space for moral vision and call to action, but in many cases religious communities have in fact mobilized significant social movement responses on other issues at both individual and community levels. In this essay, I apply a theory of socially organized denial to specific questions about climate inertia within religious communities posed in this special issue. I also unpack the question of “too little, too late,” pointing to the benefits of a suspension of doubt and engaging in ethics of responsibility in the unfolding present.
Twenty‐four‐hour physical behaviour profiles across type 2 diabetes mellitus subtypes
Authors: Henson Joseph , Tziannou Aikaterina , Rowlands Alex V. , Edwardson Charlotte L. , Hall Andrew P. , Davies Melanie J. , Yates Thomas 
Published: January 2024

AbstractAimTo investigate how 24‐h physical behaviours differ across type 2 diabetes (T2DM) subtypes.Materials and MethodsWe included participants living with T2DM, enrolled as part of an ongoing observational study. Participants wore an accelerometer for 7 days to quantify physical behaviours across 24 h. We used routinely collected clinical data (age at onset of diabetes, glycated haemoglobin level, homeostatic model assessment index of beta‐cell function, homeostatic model assessment index of insulin resistance, body mass index) to replicate four previously identified subtypes (insulin‐deficient diabetes [INS‐D], insulin‐resistant diabetes [INS‐R], obesity‐related diabetes [OB] and age‐related diabetes [AGE]), via k‐means clustering. Differences in physical behaviours across the diabetes subtypes were assessed using generalized linear models, with the AGE cluster as the reference.ResultsA total of 564 participants were included in this analysis (mean age 63.6 ± 8.4 years, 37.6% female, mean age at diagnosis 53.1 ± 10.0 years). The proportions in each cluster were as follows: INS‐D: n = 35, 6.2%; INS‐R: n = 88, 15.6%; OB: n = 166, 29.4%; and AGE: n = 275, 48.8%. Compared to the AGE cluster, the OB cluster had a shorter sleep duration (−0.3 h; 95% confidence interval [CI] −0.5, −0.1), lower sleep efficiency (−2%; 95% CI −3, −1), lower total physical activity (−2.9 mg; 95% CI −4.3, −1.6) and less time in moderate‐to‐vigorous physical activity (−6.6 min; 95% CI −11.4, −1.7), alongside greater sleep variability (17.9 min; 95% CI 8.2, 27.7) and longer sedentary time (31.9 min; 95% CI 10.5, 53.2). Movement intensity during the most active continuous 10 and 30 min of the day was also lower in the OB cluster.ConclusionsIn individuals living with T2DM, the OB subtype had the lowest levels of physical activity and least favourable sleep profiles. Such behaviours may be suitable targets for personalized therapeutic lifestyle interventions.
ICSH guidance for internal quality control policy for blood cell counters
Authors: McCafferty Richard , Cembrowski George , de la Salle Barbara , Peng Mingting , Urrechaga Eloisa 
Published: January 2024

AbstractThis paper is a description of the ICSH guidance for internal quality control (IQC) policy for blood cell counters. It follows from and links to a separate ICSH review for such policies and practices. The ICSH has gathered information regarding the current state of practice through review of published guidance from regulatory bodies, a questionnaire to six major cell counter manufacturers and a survey issued to 191 diagnostic laboratories in four countries (China, the Republic of Ireland, Spain, and the United Kingdom) on their IQC practice and approach to the use of commercial IQC materials. This has revealed diversity both in guidance and in practice around the world. There is diversity in guidance from regulatory organizations in regard to IQC methods each recommends, clinical levels to use and frequency to run commercial controls, and finally recommended sources of commercial control materials. The diversity in practice among clinical laboratories spans the areas of IQC methods used, derivation of target values, and action limits used with commercial control materials, and frequency of running commercial controls materials. These findings and their implications for IQC Practice are addressed in this guidance document, which proposes a harmonized approach to address the issues faced by diagnostic laboratories.
miR‐664a‐5p promotes experimental membranous nephropathy progression through HIPK2/Calpain1/GSα‐mediated autophagy inhibition
Authors: Shan Zhiming , Zhuang Zhenchao , Ren Peiyao , Zhao Li , Zheng Danna , Chen Wei , Jin Juan 
Published: January 2024

AbstractWe previously found that miR‐664a‐5p is specifically expressed in urinary exosomes of idiopathic membranous nephropathy (IMN) patients. Homeodomain‐interacting protein kinase 2 (HIPK2), a nuclear serine/threonine kinase, plays an important role in nephropathy. But the function of these factors and their connection in MN are unclear. To investigate the function and mechanism of miR‐664a‐5p in MN, the miR‐664a‐5p expression in HK‐2 cells, exosomes, podocytes and renal tissues were studied, as well as cell growth and apoptosis of these cells, the binding of miR‐664a‐5p to HIPK2 mRNA, the levels of relative proteins and autophagy. The MN progression in MN mice model was also studied. Albumin increased the miR‐664a‐5p content and apoptosis of HK‐2 cells, which was blocked by miR‐664a‐5p antagomir. miR‐664a‐5p bound to the 3′ UTR of HIPK2 mRNA, resulting in the up‐regulation of Calpain1, GSα shear and the inhibition of autophagy level. Autophagy inhibitor CQ blocked the protective effect of miR‐664a‐5p antagomir, HIPK2 overexpression, Calpain inhibitor SJA6017 on albumin‐mediated injury. MiR‐664a‐5p from albumin‐treated HK‐2 cells could be horizontally transported to podocytes through exosomes. Exosomes from albumin‐treated HK‐2 cells promoted progression of MN mice, AAV‐Anti‐miR‐664‐5p (mouse homology miRNA) could improve them. Albumin increases the miR‐664a‐5p level and causes changes of HIPK2/Calpain1/GSα pathway, which leads to autophagy inhibition and apoptosis up‐regulation of renal tubular epithelial cells. miR‐664a‐5p can horizontally enter podocytes through exosomes resulting in podocytes injury. Targeted inhibition of miR‐664a‐5p can reduce the apoptosis of renal tubule cells and podocytes, and may improve the MN progression.
Periodontal disease in patients with WHIM syndrome
Authors: Brenchley Laurie , McDermott David H. , Gardner Pamela J. , Silva Lakmali M. , Gao Ji‐Liang , Cho Elena , Velez Daniel , Moutsopoulos Niki M. , Murphy Philip M. , Fraser David 
Published: January 2024

AbstractAimWHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a rare combined primary immunodeficiency disease caused by gain‐of‐function (GOF) mutations in the chemokine receptor CXCR4 and includes severe neutropenia as a common feature. Neutropenia is a known risk factor for periodontitis; however, a detailed periodontal evaluation of a WHIM syndrome cohort is lacking. This study aimed to establish the evidence base for the periodontal status of patients with WHIM syndrome.Materials and MethodsTwenty‐two adult WHIM syndrome patients and 22 age‐ and gender‐matched healthy volunteers (HVs) were evaluated through a comprehensive medical and periodontal examination. A mouse model of WHIM syndrome was assessed for susceptibility to naturally progressing or inducible periodontitis.ResultsFourteen patients with WHIM syndrome (63.6%) and one HV (4.5%) were diagnosed with Stage III/IV periodontitis. No WHIM patient presented with the early onset, dramatic clinical phenotypes typically associated with genetic forms of neutropenia. Age, but not the specific CXCR4 mutation or absolute neutrophil count, was associated with periodontitis severity in the WHIM cohort. Mice with a Cxcr4 GOF mutation did not exhibit increased alveolar bone loss in spontaneous or ligature‐induced periodontitis.ConclusionsOverall, WHIM syndrome patients presented with an increased severity of periodontitis despite past and ongoing neutrophil mobilization treatments. GOF mutations in CXCR4 may be a risk factor for periodontitis in humans.
Understanding what shapes the priorities of women who are mothering in the context of intimate partner violence: A qualitative study
Authors: Broughton Sharon , Ford‐Gilboe Marilyn , Varcoe Colleen 
Published: January 2024

AbstractAimTo explore the priorities of women mothering children in the context of intimate partner violence and to understand what shapes those priorities.DesignA qualitative study using interpretive description, informed by Feminist Intersectionality adhering to the COREQ guidelines.MethodsThematic analysis was used to analyse the data.Data SourcesDialogic, semi‐structured interviews were conducted with a community sample of 20 adult Canadian women who were mothering dependent children (under 18 years) in the context of recent intimate partner violence from a current or former partner.ResultsWomen's main priorities focused on their own and their children's well‐being and creating stability related to housing and finances. Three themes identified: it's all about the kids; my safety…totally disregarded; and I have to take care of him. Multiple external factors (coercive control, structural inequities, assumptions about mothering) shape priorities and the tensions arising from competing priorities women felt compelled to address simultaneously.ConclusionPriorities of women mothering in the context of intimate partner violence are complex, shaped not only by what they want but by the limited options available to them given constraints such as income, employment, housing and service responses. Coercive control, structural inequities and assumptions about mothering are important factors influencing mothers' priorities and experiences. Better understanding mothers' priorities can support better tailored policies, services and nursing practice.Implications for NursingStructural inequities that negatively impact health and well‐being by limiting access to resources and the supports needed to enhance health can be better recognized and addressed through a trauma and violence informed care approach.ImpactThis study addressed understanding the priorities of women mothering in the context of intimate partner violence. This research will impact women mothering in the context of intimate partner violence who receive care from nurses and other providers as well as those who provide care.Reporting MethodThis study adhered to relevant EQUATOR guidelines (the COREQ checklist).No Patient or Public ContributionThe women who took part in the interviews for this study did not participate in the study design, analysis or manuscript preparation.
Diagnostic accuracy of clinical signs to detect erosive tooth wear in its early phase
Authors: Rius‐Bonet Ona , Roca‐Obis Paula , Zamora‐Olave Carla , Willaert Eva , Martinez‐Gomis Jordi 
Published: January 2024

AbstractBackgroundAgreement exists about most of the clinical features of erosive tooth wear, though no evidence supports their validity in diagnosing the condition.ObjectiveThis study aimed to determine the accuracy of clinical signs for diagnosing erosive tooth wear in a young adult general population.MethodsWe conducted a cross‐sectional study of dental students. In the first session, two examiners independently determined the presence of erosive tooth wear based on glazed enamel surfaces, morphological changes on non‐occlusal surfaces, flattening of convex areas, or any type of concavity. In the second session, one examiner recorded the presence of clinical signs according to the Tooth Wear Evaluation System. The diagnostic accuracy of each clinical sign, both alone and combined, was assessed by calculating their sensitivity and specificity for detecting erosive tooth wear and performing multivariate logistic regression models.ResultsOf the 147 participants (78 women and 69 men; median age, 22 years) we included, 76.2% had erosive tooth wear. The single clinical signs with greatest balance between the sensitivity and specificity were ‘convex areas flatten’ (63% and 71%, respectively) and ‘dull surface’ (47% and 89%, respectively). Multivariate logistic regression revealed that ‘preservation of the enamel cuff’ (odds ratio, 22) and the combination of ‘smooth silky shining, silky glazed appearance, and dull surface’ (odds ratio, 68) had the best predictive values.ConclusionsThe most accurate clinical signs for detecting early erosive tooth wear were dull surface, flattened convex areas and preservation of the enamel cuff.
Public values and sector service delivery preferences: Public preferences on contracting from simple to complex human services
Authors: Piatak Jaclyn , Jensen Colt 
Published: January 2024

AbstractNonprofit and for‐profit providers play an increasing role in public service delivery, but we know little about what shapes public service delivery preferences. Responding to calls to put the “public” back in public values theory, we examine the influence of public values on sector service delivery preferences for government, nonprofit, or for‐profit delivery across six service areas ranging from simple services such as trash collection to complex services such as child welfare. We find equity predicts a preference for government service delivery across areas, while efficiency corresponds to a preference for for‐profit service delivery. Nonprofit sector preferences varied across service areas; equity corresponds to simple services such as street maintenance, whereas effectiveness corresponds to complex human services such as elder care. Public administrators should be cognizant of the public value trade‐offs that underlie sector preferences for public services to design and implement service arrangements in line with the preferences of the public they serve.
The implosion of the Dutch surveillance welfare state
Authors: Fenger Menno , Simonse Robin 
Published: January 2024

AbstractFrom the 1990s onwards, fraud detection has become an increasingly important focus in the design and implementation of a variety of welfare schemes, including unemployment benefits, social assistance benefits, pensions, and personal care budgets. This culminated in the 2014 Fraud Act, which introduced a system of high sanction in all cases of benefit fraud, even if they were causes by administrative errors. In 2020 a parliamentary investigation committee concluded that the Dutch government had violated the foundational principles of the rule of law through the way suspected fraudsters with childcare allowances had been treated. This so‐called Childcare allowances affair undermined the support for the harsh approach to fraud and led to a series of proposals to reform the Dutch ‘surveillance welfare state’. The Dutch Childcare allowances affair is an interesting case of a social policy crisis because its origins are not external events but lie in the regular implementation of policies that have been approved and supported rather widely by politicians, policymakers and street‐level bureaucrats. In this article, we define and apply the concept ‘institutional implosion’ to analyse the Childcare allowances affair and its consequences. Moreover, we argue that the implosion in this affair follows from an extension of the target group from ‘non‐deserving’ to ‘deserving’ citizens. Whereas the Fraud Act primarily was aimed towards recipients of unemployment, disability and social assistance benefits, a change in the system of childcare allowances extended the scope of the Fraud Act to an almost universal group of parents that use childcare facilities.