bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydration Methods for Cisplatin Containing Chemotherapy: A Systematic Review
Authors: Sikking Charlotte , Niggebrugge-Mentink Kelly L , van der Sman A S Elise , Smit Roefke H P , Bouman-Wammes Esther W , Beex-Oosterhuis Marieke M , van Kesteren Charlotte 
Published: November 2023

Abstract

Introduction
Cisplatin-induced nephrotoxicity (CIN) can be prevented by fluid hydration, electrolyte supplementation, or forced diuresis; however, the best way to prevent CIN is still unknown. The aim of this study was to provide objective evidence on the optimal design of hydration schemes to prevent CIN based on an update of the literature.

Methods
A Pubmed and Embase search were conducted in December 2021 and repeated in April 2022 and March 2023. Two independent reviewers screened the articles. The included articles were categorized and reviewed per category.

Results
Twenty-seven articles met the inclusion criteria. The included studies varied widely. Four out of seven studies investigating diuretics found a protective effect of adding mannitol to the hydration scheme. All six studies investigating duration and amount of volume of hydration found that a short-hydration scheme resulted in less CIN than a longer hydration scheme. Seven out of nine articles evaluating the role of electrolytes found that magnesium supplementation reduced the risk of nephrotoxicity. Three studies investigated the safety of oral hydration and concluded that nephrotoxicity did not occur more frequently after oral hydration.

Conclusion
The hydration scheme of cisplatin should be short and consist of a relatively small amount of volume. The scheme should include mannitol and magnesium supplementation. Head-to-head studies are needed to investigate the safety of furosemide compared with mannitol and the dose of mannitol and magnesium.
Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18−39 Years) Cancer Survivors
Authors: van der Meer Daniël J , Zevenbergen Susan , Vlooswijk Carla , Bijlsma Rhodé M , Kaal Suzanne E J , Kerst Jan Martijn , Tromp Jacqueline M , Bos Monique E M M , van der Hulle Tom , Lalisang Roy I , Nuver Janine , Kouwenhoven Mathilde C M , van der Graaf Winette T A , Husson Olga 
Published: November 2023

Abstract

Background
Adolescent and young adult cancer survivors (AYAs, aged 18-39 years at first diagnosis) have a higher second cancer risk. Accelerated aging is hypothesized as underlying mechanism and has been described clinically by 6 indicators; fatigue, low quality of sleep, low mood, lack of motivation, subjective memory complaints, and poor exercise tolerance. Using patient-reported outcomes, we aimed to identify clusters of accelerated aging among AYA cancer survivors and to investigate their association with second cancer development.

Patients and Methods
Patient, tumor, and treatment data were obtained from the Netherlands Cancer Registry. Patient-reported clinical indicators and second cancer data were obtained from the SURVivors (5-20 years) of cancer in AYAs (SURVAYA) questionnaire study between 1999 and 2015. Latent class and multivariable logistic regression analyses were performed.

Results
In total, n = 3734 AYA survivors with known second cancer status (n = 278 [7.4%] second cancers) were included. Four latent clusters were identified and named based on their clinical indicator features; (1) high accelerated aging (31.3%), (2) intermediate accelerated aging without poor exercise tolerance (15.1%), (3) intermediate accelerated aging without lack of motivation (27.4%), and (4) low accelerated aging (26.2%). AYAs in the high accelerated aging cluster were more likely to have second cancer (odds ratio: 1.6; 95% CI, 1.1-2.3) compared to the low accelerated aging cluster.

Conclusion
AYAs with a higher burden of accelerated aging were more likely to develop a second cancer. Validation of the clinical indicators and how to best capture them is needed to improve (early) detection of AYAs at high risk of developing second cancer.
Real-World Outcomes of Trastuzumab Deruxtecan in Patients With HER2+ Metastatic Breast Cancer: The DE-REAL Study
Authors: Botticelli Andrea , Caputo Roberta , Scagnoli Simone , Pisegna Simona , De Laurentiis Michelino , Curigliano Giuseppe , Lambertini Matteo , Pantano Francesco , Palazzo Antonella , Paris Ida , Vernieri Claudio , Tedesco Beatrice , Giampaglia Marianna , Palleschi Michela , Ballatore Zelmira , Alesini Daniele , D’Auria Giuliana , Fabbri Agnese , Rossi Luigi , Verrazzo Annarita , Scafetta Roberta , Marinelli Daniele , Sposetti Caterina , Barberi Vittoria , Strigari Lidia , Marchetti Paolo , Santini Daniele , Fabi Alessandra 
Published: November 2023

Abstract

Background
Trastuzumab deruxtecan (T-DXd) demonstrated unprecedented efficacy in patients with pretreated HER2+ metastatic breast cancer (mBC). However, few data are available about its efficacy in routine clinical practice. In this multicenter retrospective study, we examined effectiveness and safety of T-DXd in a real-world population.

Methods
Clinico-pathological information about patients with HER2+ mBC who received T-DXd were collected from 12 Italian hospitals. HER2 status was determined locally. Patients who received at least one administration of T-DXd, as any therapy line for advanced disease were included in the analysis. The primary endpoint was real-word PFS (rwPFS).

Results
One hundred and forty-three patients were included. Median age was 66 (range: 37-90), and 4 men were included. Hormone receptor (HR) status was positive in 108 (75%) patients and negative in 35(25%). T-DXd was administered as first, second, third, or subsequent lines in 4 (3%), 16 (11%), 42 (29%), and 81 (57%) patients, respectively. Among 123 patients with measurable disease, the ORR was 68%, and the DCR was 93% (9 CRs, 74 PRs, and 30 SD). Nine (7%) patients had a primary resistance to T-DXd. With a median follow-up of 12 months, the median rwPFS was 16 months. RwPFS was 84%, 59%, and 39% at 6, 12, and 18 months, respectively. A favorable trend in rwPFS was reported in patients receiving T-DXd as I/II line versus further lines (17 vs. 15 months; P = .098). Any-grade toxicity was registered in 84 patients (59%). Most common adverse events (AEs) reported were nausea (33%), neutropenia (21%), and asthenia (21%). Liver toxicity and diarrhea were uncommon (5% and 1%). Severe toxicities was registered in 18% of patients, and the most frequent were neutropenia, nausea/vomiting, and ILD observed in 15, 2, and 3 patients. AEs led to dose reduction in 37 patients (26%). Dose reduction and AEs do not affect patients’ response and survival outcomes.

Conclusions
Efficacy and safety of T-DXd were confirmed in an unselected real-world population of HER2+ mBC. These results are consistent with the results of known findings, and no new safety concerns were reported.
Prognostic Role of p53 Immunohistochemical Status in Invasive Breast Cancer. A Retrospective Review of 1387 Cases With Luminal-Like/Her2 Negative Breast Tumors
Authors: Dajti Gerti , Serra Margherita , Cisternino Giovanni , Ceccarelli Claudio , Pellegrini Alice , Melina Marica , De Leo Antonio , Santini Donatella , Taffurelli Mario , Zanotti Simone 
Published: November 2023

Abstract

Purpose
The aim of this study was to evaluate the prognostic role of p53 immunohistochemical (IHC) expression in a large cohort of patients with hormone receptors (HR)-positive/Her2-negative primary invasive breast cancer.

Methods
Retrospective review of consecutive cases treated at our Breast Unit between 2003 and 2013. Patients were divided into 3 subgroups based on p53 IHC expression: null (0%), low (0.1%-49%), and high (≥50%) p53 expression.

Results
A total of 1387 patients were included in the study with a median follow-up of 86 months. After adjusting for age, size, node status, lymphovascular invasion, progesterone, and Ki67 expression, only null p53 immunophenotype was associated with worse disease-free survival (DFS) (OR 1.74, 95% IC, 1.11-2.71, P = .015) and distant recurrence-free survival (DRFS) (OR 1.73, 95% IC, 1.04-2.90, P = .036). Null p53 impacted significantly DFS and DRFS also in patients with early breast cancer.

Conclusions
p53 IHC expression affects survival and, thus can be a valuable tool in the management of patients with HR-positive/Her2-negative breast cancer
Definitions
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This book begins with the most controversial of all topics: definitions. Definitions of terms such as religion, spirituality, and humanism are necessary for communication purposes, for the development of measures to quantify these constructs, and ultimately, for the creation of effective interventions. Of particular concern has been the definition of spirituality, especially as it applies to conducting research on this topic. What is spirituality, and how does one measure or quantify it? How is spirituality related to religion? Is a common definition for spirituality possible, one that everyone will agree on? Such agreement is essential for conducting research that must be replicated by other investigators. Also important is that definitions of terms such as religion and spirituality not overlap with the health outcomes being studied. Otherwise, the results will be meaningless and uninterpretable. Does this also apply to the use of such terms in clinical practice?
Research Design
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
Understanding research designs is necessary not only for the design of high-quality studies that will advance the field of religion and health, but also for educators and clinicians who must interpret the findings and apply them. The chapter begins by emphasizing the research question, describing how to identify it, and illustrating how to specify a research hypothesis. It then examines different research designs, including observational designs (qualitative, cross-sectional, longitudinal) and experimental designs (single-group experimental studies, nonrandomized controlled trials, randomized controlled trials). Sample size calculation, methods of sample selection, and response rates are discussed. Length of follow-up and number of assessments are recommended for prospective studies, emphasizing the need for long-term follow-up. The authors also stress the need to assess lifetime exposure to religion to identify the “total” impact that religion has on health across the life span. Issues related to analyzing data, use of existing data sets, and importance of collaboration are also discussed.
Anxiety
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter examines the prevalence and impact of anxiety disorders in the United States and around the world. A case vignette is presented that illustrates the complex role that religion can play in generalized anxiety disorder. It then examines theoretical pathways by which religion might affect anxiety based on the known causes of anxiety. Research examining the relationship between religiosity and anxiety is reviewed, both earlier research and more recent studies. The authors review how different forms of religion, such as prayer, religious coping, and religious attendance, might impact anxiety, emphasizing the importance of uncovering potential pathways. The need for future large prospective studies and randomized controlled trials (RCTs) and replication studies is also stressed, especially for specific types of anxiety disorder. Finally, recommendations are made for health professionals and pastoral care providers, emphasizing the importance of taking a spiritual history, encouraging simple religious practices, and for licensed therapists, utilizing religiously integrated psychotherapy (particularly RCBT).
Personality Traits and Disorders
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter defines personality more generally, describes personality traits (focusing on the Five Factor Model), and reviews the diagnostic criteria for DSM-5 personality disorders (PDs). It then explores the prevalence, cost, and causes of PDs, focusing on genetic, environmental, and acquired neurobiological and physical influences. The authors hypothesize how individual religious involvement (and that of parents during their infancy and early childhood) might impact the development and course of personality traits and PDs. They then review systematic research on the relationship between religiosity, personality traits, and PDs. Research on the impact of personality on religion and the impact of religion on personality are examined. The authors stress the need for future prospective studies to determine the impact of religiosity on PD and the impact of religiously/integrated interventions on PDs.
Social Support
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter examines the relationship between religious involvement and social support, forgiveness, social capital, and altruistic behaviors. It first focuses on what religious participation can provide at the individual level, especially in terms of access to social support, learning to give and receive forgiveness, and engaging in volunteer and other community civic activities that enhance social capital and community health. The effect of religiosity on social support is then introduced by a case vignette that illustrates how religion might impact social support, the ability to forgive others to maintain social relationships, and the promotion of activities that build social capital. Next, it reviews quantitative research that has examined religiosity and its associations with or effects on social support, loneliness, forgiveness, social capital, and altruism. The chapter concludes by making recommendations for future research and suggestions on application in the clinic and the community.
Alzheimer’s Disease and Other Dementias
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter examines the effects of religious involvement on decline in cognitive function that occurs with normal aging and in the setting of Alzheimer’s disease and other dementias. After describing the six major types of dementia, the authors review research on the prevalence of dementia and the costs of providing medical, institutional, and home care to the cognitively impaired. Next, risk factors for dementia and cognitive decline are examined, with a focus on those that are modifiable. This is followed by a discussion of how religiosity might impact cognition through effects on psychological, social, environmental, and behavioral factors. The core of this chapter focuses on the research that has examined the effects of religiosity on cognitive functioning. Finally, recommendations for future research (particularly prospective studies and randomized controlled trials) are provided and applications for health professionals and religious professionals are suggested.
Cancer
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter examines the effects of religiosity on the risk of developing cancer, effects on the course of cancer, and influences on mortality from cancer. First, the prevalence, prognosis, and financial costs of cancer in the United States and worldwide are examined. This is followed by a review of the demographic, genetic, environmental, biomedical, psychological, social, and behavioral factors that contribute to cancer risk. After describing a case, the authors speculate on how religious faith and participation in the religious community might influence cancer by affecting cancer risk factors. They then review early and more recent quantitative research examining the effects of religion and religiosity on cancer risk, course, and mortality, particularly in certain population subgroups, such as African Americans and women, who are at greater risk for developing cancer. Recommendations for future research are provided, and clinical applications for clinicians and religious professionals are suggested.
Physical Disability
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter begins by defining physical disability and examining its prevalence and cost in the United States and around the world. Non-modifiable, partially modifiable, and fully modifiable risk factors for physical impairments are reviewed. Factors that affect the likelihood of developing physical disability or its progression are then examined, including positive psychological states such as having purpose and meaning, having worthwhile life goals to strive for, being optimistic and hopeful, engaging in supportive social interactions, receiving support from friends and family, and especially, providing support to others. After describing a case vignette, the authors speculate on how religious involvement might impact physical disability. Next, both early and more recent research quantitatively examining religion’s impact on developing or recovering from physical disability is reviewed, including religious/spiritual interventions that may reduce physical disability. Recommendations for future research are provided, and applications for health professionals and religious professionals are suggested.
Chronic Pain
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter begins with a description of different types of pain and a definition for the term “chronic pain.” Factors are then examined that influence the experience of chronic pain, including partially modifiable factors (socioeconomic, gene-environment interactions, medical illnesses) and fully modifiable (psychological, social, behavioral). A case vignette is presented that illustrates the effects of religion on pain, which is followed by speculation on how religious involvement might influence the severity, endurance, and consequences of chronic pain. The heart of this chapter involves a review of quantitative research examining associations between religiosity and pain, prospective studies examining the effects of religious involvement on pain, and religious/spiritual interventions for relieving pain. Recommendations for future research (and advice on how to interpret the findings from past studies) are provided, and applications relevant to clinicians and religious professionals are suggested.
Understanding the Religion–Physical Health Relationship
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
This chapter begins with a description of genetic, biological, environmental, psychological, social, and behavioral factors that affect physical health, each dependent to some extent on the individual choices that people make. This is followed by a summary of research documenting connections between religious involvement and these health determinants, referring to previous chapters in the Handbook. Theoretical causal models are then presented based on monotheistic, Eastern, and secular humanistic worldviews to help explain how religious involvement might impact physical health and longevity. Suggestions for future research are then provided, emphasizing the need for large prospective studies that follow individuals for prolonged periods of time, examining the effects of religious involvement on physical health acting through the mediators described in these models.
Health Policy Implications
Authors: Koenig Harold G. , VanderWeele Tyler J. , Peteet John R. 
Published: November 2023

Abstract
In one of the most important chapters of this Handbook, the authors examine implications for health policy at (a) federal, state, and local levels in the United States, (b) the private health sector level, and (c) government and private health system levels in other countries. This chapter begins by defining public policy and health policy, which are generally understood as laws, rules, and regulations affecting environments in which people live, work, learn, and play. Next, the authors highlight the sensitive nature and limitations of health policies, particularly those viewed as affecting religious freedoms or interfering with state-church separation. They make policy recommendations in 10 areas for authoritative bodies to consider that affect public health, emphasizing the need for health policies and their accompanying legislation to be religion-friendly and religion-respectful, viewing religion as a resource that promotes health in most cases (with some exceptions that are notable).
Permuting Cage, Permuting Music
Authors: Alonso-Minutti Ana R. 
Published: November 2023

Abstract
This chapter explores Mario Lavista’s relationship with U.S. composer John Cage (1912–1992). A close look at Lavista’s adoption of Cage’s philosophy shows that, through performative processes of interpretation and resignification, Cage becomes a symbol, Cage-the-jaula—a container that, far from being restrictive, allows for multiple permutations. Lavista and his collaborators embraced chance, indeterminacy, and graphic scores in response to a performative engagement with Cage. In conjunction with visual artist Arnaldo Coen, Lavista created the graphic score Jaula for prepared piano as a gift to Cage after he visited Mexico in 1976. A permutation of this project resulted in a multidirectional poem by Francisco Serrano. After Jaula, Lavista abandoned the use of indeterminacy and improvisation. Instead, he composed a series of works where he incorporated atomized musical quotes and a variety of literary references inserted as epigraphs in the scores. The chapter includes a discussion of early collaborative projects Lavista undertook with filmmaker Nicolás Echevarría, and Lavista’s founding of the journal Talea.
Poetic Encounters and Instrumental Affairs
Authors: Alonso-Minutti Ana R. 
Published: November 2023

Abstract
This chapter explores a series of intertextual webs present in a group of chamber pieces Lavista wrote in close collaboration with performers such as Marielena Arizpe, Leonora Saavedra, and Cuarteto Latinoamericano. The creative intimacy Lavista fostered with his collaborators, which started in 1979 and continued throughout the 1980s, was a crucial step in solidifying his compositional style. These pieces, which incorporate extended techniques and an intertextual play with poetic references, are also examples of Lavista’s affective relationship with the literary arts. Whether from his pen or from the writings of others, producing and promoting texts centered around music was another manifestation of his creativity. The journal Pauta: Cuadernos de teoría y crítica musical—founded and directed by Lavista—is discussed as an extension of Lavista’s creativity and his affective relationships with collaborators, music, literature, and the visual arts. Pauta responded to an urgent need for music-centered texts in Spanish and played a seminal role in contemporary music scenes throughout the Spanish-speaking world.