bluuebunny/crossref_metadata_2025_split huggingface dataset:
C‐Terminal Agrin Fragment as a Biomarker for Sarcopenia: A Systematic Review and Meta‐Analysis
Authors: Fatima Rida , Kim Yonghoon , Baek Suhyeon , Suram Reema Priyanka , An Sun‐Joung Leigh , Hong Yonggeun 
Published: January 2025

ABSTRACTBackgroundSarcopenia is a gradual decline in skeletal muscle mass and strength, which eventually leads to reduced physical performance. 50% of people aged 60–80 years suffer from sarcopenia. Considering the devastating outcomes and the importance of promoting healthy ageing, the diagnosis and prevention of sarcopenia is of utmost importance. Recently, C‐terminal agrin fragment (CAF) has been identified as an indicator for early diagnosis of sarcopenia. So far, systematic reviews demonstrating CAF as a biomarker for sarcopenia have been conducted, but a meta‐analysis is still needed. This study contains systematic review as well as detailed meta‐analysis to better understand the association of CAF and sarcopenia.MethodsArticles were primarily obtained from four different databases. Studies demonstrating the association between CAF and sarcopenia were selected. Data extraction and analysis were performed using STATASE 16 software. The risk of bias and quality assessment of each study was carried out using Joanna Briggs Institute (JBI) Critical Appraisal Tool. Meta‐regression, subgroup and sensitivity analysis were conducted to identify the source of heterogeneity.ResultsSeventeen studies were included in the qualitative analysis, out of which 10 were included in the quantitative analysis. The meta‐analysis showed that CAF levels were significantly higher in sarcopenia patients, with an effect size of 1.93 (ROM = 1.93, 95% CI [1.49 to 2.36]; p = 0.00) and 1.38 (ROM = 1.38, 95% CI [0.94 to 1.83], p = 0.00) when compared with non‐sarcopenic and non‐sarcopenic (other co‐morbidities) group, respectively. CAF levels were also negatively associated with hand grip strength (HGS) and skeletal muscle index (SMI) with an effect size of 1.09 (ROM = 1.09 with 95% CI [1.05 to 1.13], p = 0.00) and 1.10 (ROM = 1.10 with 95% CI [1.05 to 1.14], p = 0.00), respectively. Meta‐regression and subgroup analysis revealed that although sarcopenia is associated with increasing age, the correlation between CAF and age was statistically insignificant (p = 0.44), suggesting that the variation of age among sarcopenia patients could be source of heterogeneity among studies. All the studies included in the meta‐analysis reported low risk of bias.ConclusionsOur meta‐analysis concluded that elevated CAF levels were associated with sarcopenia and decreased HGS and SMI. CAF could serve as a valuable marker for the early detection and monitoring of sarcopenia, ultimately facilitating the management and treatment of this debilitating condition.
Unlocking the potential of biowaste: Sustainable strategies to produce valuable industrial products
Authors: Rasheed Faiza , Kayani Waqas Khan , Asghar Muhammad Usama , Farrukh Aftab , Gul Sanam , Khan Ibrahim , Nazli Naushaba 
Published: January 2025

AbstractGlobal solid waste generation is expected to double by 2050 from the present annual level of 2.01 metric ton. Traditional biowaste treatment methods, such as landfilling and incineration, cannot meet the need to deal with gigantic amounts of waste and reduce environmental harm. This review critically evaluates existing sustainable waste management strategies highlighting their role in transitioning to a “reuse and recovery” paradigm. Sustainable waste management refers to conserving resources and protecting human health, society, and the environment. In this context, this review examines the current advancements and potential trends in using widely available biowaste in novel applications to produce key biofuels (such as biogas and biodiesel) and resources such as corrosion inhibitors, asbestos‐free brake pads, nutrient‐rich functional foods, bio‐cement, bio‐based fertilizer, and biodegradable plastic. Among these, biowaste‐to‐energy conversion (e.g., biogas production) and biodegradable plastic synthesis emerge as particularly impactful strategies due to their scalability and potential to address both waste reduction and resource recovery goals. The strategic utilization of biowaste resources into novel products holds significant promise in mitigating sustainability problems, offering renewable alternatives that are biodegradable and free of harmful additives.
An Efficient Catalyst‐Free Protocol for the Synthesis of Various CNContaining Heterocycles at Ambient Temperature
Authors: Huang Qiuyun , Xie Xinmei , Ren Huijun , Yang Liu , Fan Qiangwen , Zhu Haibo , Xie Zongbo , Le Zhanggao 
Published: January 2025

ABSTRACTHerein, we reported an efficient synthetic protocol to access various N‐containing heterocycles at ambient temperature without using any catalysts and additives. The protocol showed good tolerance to dozens of substrates affording quinoxalines, thiazoles, and imidazoles with isolated yields of up to 94%, wherein 26 examples were synthesized in total. Moreover, this method was also readily applicable to gram‐scale synthesis. Finally, a plausible reaction mechanism was proposed according to the experimental results.
An Evaluation of Generic and Disease‐Specific Patient‐Reported Outcome Measures to Assess the Impact of Percentage of Scalp Hair Loss on Health‐Related Quality of Life in a European Population
Authors: Hanson K. A. , Marwaha S. , Kurosky S. K. , Harries M. , Anderson P. , Piercy J. , Basey V. , Austin J. , Law E. H. 
Published: January 2025

ABSTRACTBackgroundHair loss due to alopecia areata (AA) can negatively impact patients’ health‐related quality of life (HRQoL). Patient‐reported outcome measures (PROMs) like the EQ‐5D‐5L and the Alopecia Areata Patient Priority Outcomes (AAPPO) represent treatment outcomes and can guide decision‐making. However, the EQ‐5D‐5L potentially underestimates AA‐specific impacts, while the AAPPO may provide a more disease‐specific assessment.ObjectivesThis study uses the EQ‐5D‐5L and the AAPPO emotional symptom (ES) and activity limitations (AL) subscales to characterise HRQoL among patients with AA.MethodsThis analysis uses secondary data from the Adelphi Alopecia Areata Disease Specific Programme (AA‐DSP), a survey of dermatologists and patients with AA in five European countries. Included patients completed a survey containing the EQ‐5D‐5L and AAPPO. Descriptive summary statistics were reported for AAPPO ES/AL subscales and EQ‐5D‐5L scores, overall and stratified by physician‐reported percentage of scalp hair loss (%SHL). Cramer's V effect sizes were calculated across each of the AAPPO ES/AL and EQ‐5D anxiety/depression and usual activities items to examine the relationship between varying degrees of SHL and the PROMs.ResultsFour hundred thirty‐five patients with AA completed the AAPPO and EQ‐5D‐5L. The mean (SD) overall EQ‐5D‐5L index and EQ‐VAS score was 0.85 (0.15) and 74.07 (17.86), respectively. The mean (SD) overall AAPPO ES and AL subscale scores were 1.70 (1.03) and 0.88 (0.93), respectively. For the AAPPO ES and AL items, effect sizes were largest between the extreme values of SHL (0%–10% vs. 100%), while the effect sizes between intermediate SHL groups (e.g., 11%–20% and 21%–49%) tended to be smaller. The two EQ‐5D‐5L items demonstrated lower effect size values.ConclusionsOur findings suggest the AAPPO suitably discriminates between clinically relevant groups of patients with AA. The EQ‐5D‐5L was not as effective in measuring the specific psychological or social dimensions by SHL, potentially underestimating disease burden among patients with AA.
Lack of validated patient‐reported outcome tools persists in paediatric and adolescent hip arthroscopy—A systematic review
Authors: Ade‐Conde Ayomide Michael , Amoyaw Brendan , Bourgeault‐Gagnon Yoan , Abdel Khalik Hassaan , Simunovic Nicole , Ayeni Olufemi R. 
Published: January 2025

AbstractPurposeThis systematic review aimed to (1) identify commonly used patient‐reported outcome (PRO) tools in paediatric hip arthroscopy and (2) assess whether the PROs used in this population have been formally validated.MethodsTwo systematic searches of MEDLINE, Embase and CENTRAL, from inception to 31 March 2024 and 22 August 2024, respectively, followed the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. The first search identified PRO instruments used in studies on hip arthroscopy in patients aged 19 and under. The second focused on the clinimetric properties of these tools in paediatric hip arthroscopy. PRO utilization was stratified by pathology, trends over time and publication type. Use of the Consensus‐based Standards for the Selection of Health Measurement Instruments tool, and a descriptive analysis, were planned to assess the eligible clinimetric studies.ResultsFifty‐seven studies were included, identifying 10 hip‐specific and 5 nonspecific PROs. The second search did not identify any clinimetric studies on these tools used in paediatric patients. The most commonly reported hip‐specific PRO were the modified Hip Harris Score (n = 48), the Hip Outcome Score–Sport‐Specific Subscale (n = 25) and the Non‐Arthritic Hip Score (n = 20). Hip arthroscopy was used to treat over seven different conditions, with femoroacetabular impingement being the most common (n = 41, 77%). Between 2005 and 2024, the variety of hip‐specific PROs increased, with seven new ones introduced by 2019–2024. Additionally, this study found a relatively equal distribution of outcomes across presentation abstracts and manuscripts.ConclusionsThe key finding of this study is the ongoing lack of hip‐specific PRO tools in the paediatric hip arthroscopy literature, with reliance on adult‐derived instruments. The absence of clinimetric studies and heterogeneity in PRO use emphasises the need for standardized, paediatric‐specific tools. Developing and validating such instruments should be prioritized to ensure accurate, age‐appropriate outcome assessment and care.Level of EvidenceLevel III.
Development of learning health system competency items related to health and healthcare equity and justice for rehabilitation researchers
Authors: Dunlap Pamela M. , Poploski Kathleen M. , Anderson Catherine A. , Annaswamy Thiru M. , Clark Melissa A. , Coyle Peter C. , Douglas Natalie F. , Flores Ann Marie , Freburger Janet K. , Hafner Brian J. , Harwood Kenneth J. , Hoffman Jeanne M. , Kinney Adam R. , Resnik Linda , Ressel Kristin , Whitten Margarite J. , McDonough Christine M. 
Published: January 2025

AbstractIntroductionIn 2021, the Learning Health Systems Rehabilitation Research Network (LeaRRn) developed and administered a needs assessment survey, based on the Agency on Healthcare Research and Quality's (AHRQ's) original seven domains of learning health systems (LHS) researcher core competencies, to identify knowledge and interest in LHS research competencies among rehabilitation researchers. In 2022, the AHRQ added a new health and healthcare equity and justice (HE) domain to the existing seven domains for LHS researcher core competencies.MethodsLeaRRn utilized methods similar to those employed in the development of their original needs assessment survey to generate and refine competency items for the HE domain. In this report, we describe the methods used to develop these HE competency items.Results & ConclusionsOther training programs and LHS researchers may use the competency items developed for this needs assessment survey to identify training opportunities in the HE domain.
Incorporating zero‐plane displacement in roughness length estimation and exposure correction factor calculation
Authors: Fang Pingzhi , Yu Hui , Zhao Mingwei , Yu Wenbo 
Published: January 2025

AbstractExposure correction is necessary for removing the distortion effects induced by nonstandard local exposure in raw near‐ground wind speed datasets. The accurate calculation of the exposure correction factor () for wind speeds requires reliable input of the local aerodynamic roughness length (). In this study, we evaluate the performance of an formula suggested by the World Meteorological Organization and the estimation of based on gustiness model. The estimation of will be more reasonable if local zero‐plane displacement () is considered under rough terrain conditions. An empirical linear relationship is introduced, and the ratio is recommended for meteorological stations under rough terrain conditions in China coastline. The incorporation of into the formula suggested by the World Meteorological Organization is further performed. Sensitivity analyses indicate that the estimates and values are highly sensitive to factors such as mean wind duration, gust duration and anemometer height. Finally, we conducted case studies across 15 meteorological stations in China coastline, which revealed that our proposed method enhances the accuracy of both estimation and calculation in comparison to the existing models.
Discussion on the Optimal Controls Results for Fractional Systems With Atangana–Baleanu Derivative
Authors: Johnson M. , Vijayakumar V. 
Published: January 2025

ABSTRACTIn this paper, we present the optimal controls for a system governed by Atangana–Baleanu fractional differential systems in Banach spaces. We verify the existence of the mild solutions through the concepts of fractional calculus, semigroup theory, and Leray–Schauder's fixed point theorem. Likewise, we discuss the existence of optimal controls for the corresponding fractional control system. Furthermore, an example is offered to define the theoretical result.
Approximation Properties of Truncated Nonlinear Mihesan Operators
Authors: Parmar Hardikkumar B. , Patel Prashantkumar G. 
Published: January 2025

ABSTRACTThe Mihesan operator is the generalization of well‐known positive linear operators like Bernstein operators, Szász–Mirakjan operators, Baskakov operators, and Lupaş operators. In order to expand the theory of positive operators beyond the linear example, nonlinear positive operators are essential. We have introduced the nonlinear Mihesan operators and find the approximation properties of Truncated Mihesan operators with all steps in this note.
Atomic Adsorption Energies Prediction on Bimetallic Transition Metal Surfaces Using an Interpretable Machine Learning‐Accelerated Density Functional Theory Approach
Authors: Tomacruz Jan Goran T. , Castro Michael T. , Remolona Miguel Francisco M. , Padama Allan Abraham B. , Ocon Joey D. 
Published: January 2025

AbstractIn this study, we identified features with the largest contributions and property trends in predicting the adsorption energies of carbon, hydrogen, and oxygen adsorbates on transition metal (TM) surfaces by performing Density Functional Theory (DFT)‐based calculations and Machine Learning (ML) regression models. From 26 monometallic and 400 bimetallic fcc(111) TM surfaces obtained from Catalysis‐hub.org, three datasets consisting of fourteen elemental, electronic, and structural properties were generated using DFT calculations, site calculations, and online databases. The number of features was reduced using feature selection and then finely‐tuned random forest regression (RFR), gaussian process regression (GPR), and artificial neural network (ANN) algorithms were implemented for adsorption energy prediction. Finally, model‐agnostic interpretation methods such as permutation feature importance (PFI) and shapely additive explanations (SHAP) provided rankings of feature contributions and directional trends. For all datasets, RFR and GPR demonstrated the highest prediction accuracies. In addition, interpretation methods demonstrated that the largest contributing features and directional trends in the regression models were consistent with structure‐property‐performance relationships of TMs like the d‐band model, the Friedel model, and higher‐fold adsorption sites. Overall, this interpretable ML–DFT approach can be applied to TMs and their derivatives for atomic adsorption energy prediction and model explainability.
Effect of Teachers' Emotional Intelligence on Emotional Blackmail at Work With Emotional Labor as the Mediating Variable and Burnout as the Moderating Variable
Authors: Chen Yin‐Che , Chu Hui‐Chuang , Chueh Chang‐Yu 
Published: January 2025

ABSTRACTThe psychological well‐being of teachers is essential in education, as it directly impacts teaching effectiveness and student outcomes. Recently, emotional blackmail has emerged as a critical concern for both physical and mental health, yet empirical studies on this topic, particularly among teachers, remain limited. Teaching is a profession characterized by intensive emotional labor, which can increase vulnerability to burnout. Teachers with lower emotional intelligence may struggle to manage the pressures associated with emotional blackmail, leading to heightened stress and a potential decline in job satisfaction. This study examines the relationships among emotional intelligence, emotional labor, job burnout, and emotional blackmail among teachers in Taiwan. Analyzing responses from 1160 participants using hierarchical regression, the findings reveal a significant negative correlation between emotional intelligence and perceived emotional blackmail (β = −0.167, p < 0.001), partially mediated by emotional labor and moderated by burnout. These insights underscore the need for targeted emotional intelligence training and burnout mitigation strategies to foster healthier educational environments. Further investigation into situational and contextual factors influencing teachers' emotional health is recommended to strengthen the study's implications for educational practice.
Elder Black Women Science Teachers (Re)member: An Examination of Science Identity Formation for Curious Young Black Girls
Authors: Riley Alexis D. 
Published: January 2025

ABSTRACTTo specifically add to the literature on Black girls cultivating their science genius, Black women science teachers ‘talk back’ by sharing and developing their own narratives about being a science‐curious young Black girl and how they use that experience to actualize their vision for liberatory science teaching. This international, qualitative study centers the (re)flections and pedagogical practices of five “elder” Black women science teachers who have surpassed and live within some of the confines of “science as white property.” Utilizing an Endarkened Feminist Epistemology, participants engage in the art of (re)membering by writing poems to their former young Black girl self as a result of (re)flecting on creating the educational structures they wish they had experienced. The findings and discussion indicate that access to science professionals at home or a once‐in‐a‐lifetime scholarship gave the participants the privilege to be curious. Despite these privileges these women had to persist through the culture of science that told them they didn't belong. Yet and still, they speak back with power and a determination to be seen and heard. This study provides implications for the curricular shifts and ideologies that honor Black girls in K‐8 formal science spaces by merging liberatory teaching frameworks in science teaching and learning. Implications are also provided for professional development for Black women science teachers and other historically excluded groups, giving them space to (re)flect and to unearth their truth through reflecting on their history and collaborating with peers.
Hydrophosphorylation of 1,1,1,3,3,3‐hexafluorobut‐2‐yne (HFB) with Diethyl Hydrogenphosphonate: Attractive Synthetic Route to Various Types of CF3‐Containing Phosphonates
Authors: Pavlenko Natalia V. , Shishkina Svitlana V. , Stepanova Diana S. , Yagupolskii Yurii L. , Peng Sheng 
Published: January 2025

AbstractThe reaction of 1,1,1,3,3,3‐hexafluorobut‐2‐yne (1) (HFB) with diethyl hydrogenphosphonate (2) was investigated under various conditions by promotion with transition metal catalysts, under heating without catalysts and by tert‐amine catalysis. In all cases, double addition was the predominant reaction forming bis(phosphonic) acid esters 3, which were then converted to the corresponding acids 8 and salts 9. Compounds 3, 8, and 9 containing two chiral carbon atoms and three types of substituents exist as mixtures of diastereomers in the meso and dl forms, which can undergo epimerization. The mono adduct 4 was extremely unstable and capable of telomerization under rhodium complex catalysis or heating at 150 °C in catalyst free conditions. Isolated telomer 5 (n = 2) was characterized by X‐ray crystallography and NMR method. Dephosphorylation of phosphonate 5 by Me4NF occurred quantitatively to give, unexpectedly, internal salt of pyrrolidine 12 containing four trifluoromethyl substituents.
Novel Binary and Ternary Biocomposites (Zeolitic Imidazolate Framework (ZIF‐67), Graphene Oxide (GO) Nanosheet, and Guar Gum (GG) Biopolymer): Synthesis and Adsorption of Malachite Green Cationic Dye
Authors: Moradi Alireza , Kalaee Mohammad Reza , Moradi Omid , Mohammad Mahmoodi Niyaz , Zaarei Davood 
Published: January 2025

AbstractAccording to the research, zeolitic imidazolate framework (ZIF‐67) and graphene oxide (GO) nanosheets were synthesized with a guar gum (GG) biopolymer substrate to form two‐component hybrid biocomposites: GO/ZIF‐67 (GOZ), GG/ZIF‐67 (GZ), and three‐component hybrid with GO/GG/ZIF‐67 (GGZ) substrate polymer. These composites were used to adsorb malachite green (MG) cationic dye from an aqueous solution at room temperature. The chemical fractions, morphological and structural properties of the hybrid biocomposites were determined using a Fourier transform infrared spectrometer (FTIR), scanning electron microscope (SEM), X‐ray diffraction (XRD), and Brunauer–Emmett–Teller (BET) analyses. The adsorption of MG dye was carried out on the two‐component and three‐component hybrid biocomposites with a polymer substrate under different experimental conditions. The high surface area of GZ, GOZ, and GGZ was 1362.89, 754.89, and 833.67 m2 g−1, respectively, and the total pore volume was 0.90 cm3 g−1 for GZ, and 0.51 cm3 g−1 for GOZ and GGZ, respectively. The removal of MG pollutant follows the pseudo‐second order model and the Langmuir model. The adsorption mechanism involves hydrogen bonding, π‐π stacking, and electrostatic interactions. The GOZ, GZ, and GGZ hybrid biocomposites showed the maximum removal efficiency at 66.6%, 74.4%, and 90.1%, respectively. The data show that the removal of MG after 3 cycles was 90%, 86%, and 82%.
Synthesis and Spectral Studies of Iron‐Catalyzed Multicomponent Synthesis of 4‑Phosphorylated 4H‑Chromenes from 2‐Hydroxybenzyl Alcohols
Authors: Mukhtar Sayeed , Alahmdi Mohammed Issa , Parveen Humaira , Alsharif Meshari A , Waheed Mohd 
Published: January 2025

AbstractA facile, mild, effective, and multicomponent protocol for the production of 4‑phosphorylated‐4H‑chromenes through an aldol condensation, Michael addition, and cyclization was established. The C─C, C─P, and C─O bonds were constructed during the reaction to produce the desired product from 2‐hydroxybenzyl alcohols. The synthesized compounds were characterized by standard techniques. The important features of this protocol are operational simplicity, moderate reaction conditions, the use of a low‐cost iron complex, and high atom economy.