bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaffolding competence‐based learning design in the dental simulation curriculum
Authors: Foxton Richard , San Diego Jonathan P. , Lu Emily , Rajadurai Susha , Bartlett Anitha , McIlwane Clare , Austin Rupert , Srisontisuk Pinsuda , Sagoo Anika K. , Piper Kim 
Published: December 2023

AbstractIntroductionLearning in a clinical domain in dentistry is complex and learners may face uncertain clinical scenarios. A simulation curriculum can be designed to have simple clinical scenarios and learning activities which progress in complexity and employ competence assessments of simulated clinical practice before students can undertake authentic practice on patients. This paper presents how scaffolding of competence can be used for designing learning with simulators (haptics and phantom head) demonstrated in a specific domain in restorative dentistry.MethodsA collaborative workshop as a research approach was undertaken to inform the iterative analysis, development, and discussion on scaffolding the learning design with respect to competence assessments of learning cavity preparation with simulation‐based learning technologies. A workshop was conducted, which was collaborative and involved design negotiations between researchers, technologists, and teachers/practitioners in developing the simulation curriculum.ResultsA competence assessment with feedback in a specific domain in preparing interproximal caries was used as a context to describe how the learning activities and outcomes were designed to meet assessment of competence with varied levels of simple to complex learning activities and structured sessions.ConclusionSimulation curriculum can be designed and implemented by scaffolding the level of competence that can be learned using simulation between haptics and phantom‐head. This brings impetus to the need in meeting the relevant competence criteria in context to a specific affordance of the simulation‐based learning technologies to provide optimal patient‐centred holistic care.
Perceived double reduction policy, perception of educational involution: Exploring the mediating role of parental educational anxiety and the moderating influence of gender—Insights from a survey conducted in a City in China
Authors: Zhang Shuyang , Sulong Rose Manisah Binti , Hassan Norlizah Binti Che 
Published: December 2023

AbstractEducation policies align with evolving needs and changes in education. Two years ago, the double reduction policy was widely welcomed. But new challenges have emerged now, it is necessary to examine whether it still meets parental expectations, and whether adjustments in details are needed. We investigated parents' perception of policy implementation intensity; and its relationship with parents' perception of educational involution; and parents' educational anxiety, as well as the roles played by gender. Findings highlight parents who perceive a stronger policy implementation intensity experience higher levels of educational anxiety and are more likely to feel educational involution; education anxiety acts as a mediator, while gender plays a moderating role. We highlighted policy's advantages while emphasizing the necessity to avoid policy rigidity and one‐size‐fits‐all. We recommend establishing a flexible, real‐time parental feedback mechanism and promoting continuous monitoring and evaluation. This approach would enable it to meet the changing demands of education.
Effect of ST36 electroacupuncture on the switch of skeletal muscle fibres in mice with sciatic nerve dissociation
Authors: Wang Jinghua , Yao Xiuhua , Xiong Xiaoyue , Liu Yumei , Zhao Wei , Zhang Xiaoyu , Li Xinrong , Wang Jiaqi , Lei Cheng , Jiang Wei , Zhang Kefan , Li Xiangyang , Weng Yuting , Li Jie , Zhang Ran , Zhang Zhaonan , Li Hulun , Kong Qingfei , Tian Sijia , Lv Yanhua , Mu Lili 
Published: December 2023

AbstractSkeletal muscle is striated muscle that moves autonomously and is innervated by peripheral nerves. Peripheral nerve injury is very common in clinical treatment. However, the commonly used treatment methods often focus on the regeneration of the injured nerve but overlook the pathological changes in the injured skeletal muscle. Acupuncture, as the main treatment for denervated skeletal muscle atrophy, is used extensively in clinical practice. In the present study, a mouse model of lower limb sciatic nerve detachment was constructed and treated with electroacupuncture Stomach 36 to observe the atrophy of lower limb skeletal muscle and changes in skeletal muscle fibre types before and after electroacupuncture Stomach 36 treatment. Mice with skeletal muscle denervation showed a decrease in the proportion of IIa muscle fibres and an increase in the proportion of IIb muscle fibres, after electroacupuncture Stomach 36. The changes were reversed by specific activators of p38 MAPK, which increased IIa myofibre ratio. The results suggest that electroacupuncture Stomach 36 can reverse the change of muscle fibre type from IIb to IIa after denervation of skeletal muscle by inhibiting p38 MAPK. The results provide an important theoretical basis for the treatment of clinical peripheral nerve injury diseases with electroacupuncture, in addition to novel insights that could facilitate the study of pathological changes of denervated skeletal muscle.
Further data on the establishment of Coptodisca lucifluella (Clemens, 1860) (Lepidoptera: Heliozelidae) in Romania
Authors: Mustățea Roxana‐Violeta , Chireceanu Constantina 
Published: December 2023

AbstractFollowing its first report in Romania in August 2022, more data regarding the walnut shield bearer Coptodisca lucifluella was collected. The leafminer moth is an invasive species of North American origin that entered Europe in 2010 (in Italy), and then spread to Hungary, Ukraine, Bulgaria and Romania. It is not an economically important pest alone but in association with other stresses affecting walnut trees, over time, it could contribute to their premature decline. In Romania, C. lucifluella was identified in 24 localities in eight counties and in Bucharest. The main host is the common walnut, Juglans regia (L.), while secondary hosts include the black walnut Juglans nigra (L.), Caucasian walnut Pterocarya fraxinifolia (Lam.) Spach and the pecan nut tree Carya illinoinensis (Wangenh & K. Koch). All walnut trees inspected in 2022 were affected by the leafminer to a greater or lesser extent. The proportion of attacked leaves per tree, evaluated in Northern Bucharest and Moara Domnească in the south of the country respectively, was 40% and 41% in August and increased to 69 and 93%, in October. Inside the mines, our team discovered a significant number of parasitoid larvae and pupae. These were kept in the laboratory until the emergence of adults which were photographed, but so far remain unidentified. The rate of parasitism was 17.4% in N. Bucharest and 31.8% in Moara Domnească.
Antimalarial activities of benzothiazole analogs: A systematic review
Authors: Tran Linh , Tu Vo Linh , Dadam Mohammad Najm , Aziz Jeza Muhamad Abdul , Duy Tran Le Dinh , Ahmed Hajer Hatim Hassan , Kwaah Patrick Amanning , Quoc Hoang Nghia , Van Dat Truong , Mizuta Satoshi , Hirayama Kenji , Huy Nguyen Tien 
Published: December 2023

AbstractBackgroundBenzothiazole derivatives have been reported to possess a wide range of biological activities, including antimalarial activity. This systematic review aims to summarize and evaluate the antimalarial activities of benzothiazole analogs.MethodsWe conducted an electronic search using nine databases in October 2017 and subsequently updated in September 2022. We included all original in vitro and in vivo studies that documented the antimalarial activities of compounds containing benzothiazole analogs with no restriction. The risk of bias of each included study was assessed by ToxRTool.ResultsTwenty‐eight articles were included in our study, which are in vitro, in vivo, or both. Of these, 232 substances were identified to have potent antiplasmodial activity against various strains of the malaria parasite. Benzothiazole analogs show different antimalarial mechanisms, including inhibition of Plasmodium falciparum enzymes in in vitro studies and inhibition of blood parasites in in vivo studies.ConclusionsBenzothiazole derivatives are promising substances for treating malaria. The structure–activity relationship studies suggest that the substitution pattern of the benzothiazole scaffold plays a crucial role in determining the antimalarial activity of the analog.
Integration of a dental hygienist into the interprofessional long‐term care team
Authors: Villacorta‐Siegal Nelly , Joseph Karen , Gardner Sandra , Smith Jagger , Gallucci Christina E. , Aleong Rosanne , Chvartszaid David 
Published: December 2023

BackgroundTo address poor oral health of residents in long‐term care homes (LTCH), this study explored the process of integrating an educational resource and a dental hygienist on the interprofessional care team.MethodsThis convergent mixed‐methods study took place at a 472‐bed LTCH in Toronto, Canada from February to August 2018. Nurses employed at the LTCH participated in the study. During the study period, a dental hygienist was integrated into an interprofessional LTCH team. Nurses completed an online eLearning module about using the Oral Health Assessment Tool (OHAT) when referring residents' oral health concerns to a. Pre/post knowledge quizzes, module feedback and satisfaction surveys were administered. A retrospective chart review examined OHAT use and compared nurse and dental hygienist oral health assessments. Two cycles of semi‐structured interviews with five nurses explored experiences with the eLearning module, OHAT and integration of the dental hygienist into the team.ResultsNurses scored well on the knowledge quizzes and reported comfort in using the OHAT to refer oral concerns to a dental hygienist; however, actual use was minimal. oral health issues were under‐reported by nurses on the Resident Assessment Instrument–Minimum Data Set (RAI‐MDS); the dental hygienist reported significantly more debris, teeth lost and carious teeth (all P < 0.0001). Qualitative analysis indicated that the nurses valued dental hygienist integration into the team. Using knowledge mobilisation practices, a new oral health referral tool was developed.ConclusionsThis study highlights the feasibility and desirability of an oral health eLearning module, practical assessment tools and participation of a dental hygienist on the LTCH interprofessional care team.
A place for public concerns in parole decision making in Japan
Authors: Toda Saori 
Published: December 2023

AbstractIn recent years, parole decision makers have grappled with an intensifying challenge in addressing public concerns. While discussions on the rise of ‘parole populism’ have emerged, especially in Canada, the United States, Australia and England and Wales, little is known about the way public concerns influence parole release in Japan. This article engages in legal‐systematic analysis of the intricate relationship between public concerns and Japanese parole decision making in general and release from life imprisonment in particular. The article argues that, while Japanese selective parole decision making considering public concerns in secrecy may have partially contributed to political rhetoric encouraging parole, it also poses unique challenges distinct from those in Anglophone jurisdictions. It reveals the value of fostering a transparent and accountable parole decision‐making system to promote a more balanced and fairer approach to parole in the Japanese context.
Australia and New Zealand consensus position statement: use of COVID‐19 therapeutics in patients with haematological malignancies
Authors: Campbell Ashlea , Teh Benjamin , Mulligan Stephen , Ross David M. , Weinkove Robert , Gilroy Nicole , Gangatharan Shane , Prince Henry Miles , Szer Jeff , Trotman Judith , Lane Steven , Dickinson Michael , Quach Hang , Enjeti Anoop K. , Ku Matthew , Gregory Gareth , Hapgood Gregory , Ho Phoebe Joy , Cochrane Tara , Cheah Chan , Greenwood Matthew , Latimer Maya , Berkahn Leanne , Wight Joel , Armytage Tasman , Diamond Peter , Tam Constantine S. , Hamad Nada 
Published: December 2023

AbstractDespite widespread vaccination rates, we are living with high transmission rates of SARS‐CoV‐2. Although overall hospitalisation rates are falling, the risk of serious infection remains high for patients who are immunocompromised because of haematological malignancies. In light of the ongoing pandemic and the development of multiple agents for treatment, representatives from the Haematology Society of Australia and New Zealand and infectious diseases specialists have collaborated on this consensus position statement regarding COVID‐19 management in patients with haematological disorders. It is our recommendation that both patients with haematological malignancies and treating specialists be educated regarding the preventive and treatment options available and that patients continue to receive adequate vaccinations, keeping in mind the suboptimal vaccine responses that occur in haematology patients, in particular, those with B‐cell malignancies and on B‐cell‐targeting or depleting therapy. Patients with haematological malignancies should receive treatment for COVID‐19 in accordance with the severity of their symptoms, but even mild infections should prompt early treatment with antiviral agents. The issue of de‐isolation following COVID‐19 infection and optimal time to treatment for haematological malignancies is discussed but remains an area with evolving data. This position statement is to be used in conjunction with advice from infectious disease, respiratory and intensive care specialists, and current guidelines from the National COVID‐19 Clinical Evidence Taskforce and the New Zealand Ministry of Health and Cancer Agency Te Aho o Te Kahu COVID‐19 Guidelines.
The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity
Authors: Putnam Christopher D. , Broderick Lori , Hoffman Hal M. 
Published: December 2023

SummaryFrom studies of individual families to global collaborative efforts, the NLRP3 inflammasome is now recognized to be a key regulator of innate immunity. Activated by a panoply of pathogen‐associated and endogenous triggers, NLRP3 serves as an intracellular sensor that drives carefully coordinated assembly of the inflammasome, and downstream inflammation mediated by IL‐1 and IL‐18. Initially discovered as the cause of the autoinflammatory spectrum of cryopyrin‐associated periodic syndrome (CAPS), NLRP3 is now also known to play a role in more common diseases including cardiovascular disease, gout, and liver disease. We have seen cohesion in results from clinical studies in CAPS patients, ex vivo studies of human cells and murine cells, and in vivo murine models leading to our understanding of the downstream pathways, cytokine secretion, and cell death pathways that has solidified the role of autoinflammation in the pathogenesis of human disease. Recent advances in our understanding of the structure of the inflammasome have provided ways for us to visualize normal and mutant protein function and pharmacologic inhibition. The subsequent development of targeted therapies successfully used in the treatment of patients with CAPS completes the bench to bedside translational loop which has defined the study of this unique protein.
Preparation and mechanical behavior of Si3N4 composite ceramics with brick‐and‐mortar structure
Authors: Zhao Shihui , Zhao Yi , Zhang Qifan , Sang Guolong , Xi Xiaoqing , Yang Jinlong 
Published: December 2023

AbstractThe nacre with brick‐and‐mortar structure enables multiple toughening and strengthening mechanisms, and bioinspired ceramics with brick‐and‐mortar structure have been attracting much attention from many researchers. However, the process of constructing precise and uniform microstructure is quite complicated. Herein, we propose a novel and facial method to fabricate composite ceramics with brick‐and‐mortar structure. Si3N4 microspheres prepared by particle‐stabilized foaming and centrifugal spray drying were directly hot pressed after being immersed in suspension and evenly wrapped with ZrO2. The mechanical properties of composite ceramics were optimized by adjusting the pressure during sintering and ZrO2 content. When ZrO2 content was 10 wt% and sintering pressure was 5 MPa, the fracture toughness of ZrO2/Si3N4 brick‐and‐mortar composite ceramics reached 9.02 MPa·m1/2, and the flexural strength was 784 MPa, which were increased by 46.9% and 26.5%, respectively, compared with the control group. While retaining excellent flexural strength, the strong interface also induces crack to deflect and branch along the two‐phase interface of the brick‐and‐mortar structure caused by the residual stress, which was derived from the mismatch of the thermal expansion coefficient of ZrO2 and Si3N4, consuming more fracture energy to achieve the toughening effect.
Expanding the Health Belief Model for exploring inpatient fall risk perceptions: A methodology paper
Authors: Dolan Hanne , Taylor‐Piliae Ruth 
Published: December 2023

AbstractAimsInpatient falls among older adults are a relentless problem, and extant inpatient fall prevention research and interventions lack the older adults' perspectives and experiences of their own fall risk in the hospital. Theory‐guided research is essential in nursing, and the purpose of this paper was to describe the process of developing a theoretical framework for a phenomenological nursing study exploring older adults' lived experiences of being at risk for falling in the hospital.MethodBased on philosophical nursing underpinnings, the Health Belief Model (HBM) was selected as the theoretical model. The limitations of the model led to expansion of the model with established concepts associated with accidental falls among older adults.ResultsThe HBM was selected as the guiding model due to its ability to capture a broad range of perceptions of a health threat. The HBM was expanded with the concepts of embarrassment, independence, fear of falling, dignity and positivity effect. The addition of these concepts made the theoretical framework more applicable to age‐related developmental behaviours of older adult and more applicable to nursing research.ConclusionThe Expanded HBM theoretical framework may guide future nursing research to develop fall prevention interventions to decrease fall rates among hospitalized older adults.Patient or Public ContributionNo Patient or Public Contribution.
Prognostic impact and immunotherapeutic implications of NETosis‐related gene signature in gastric cancer patients
Authors: Xiang Tian , Wei Zhenhua , Ye Chen , Liu Gao 
Published: December 2023

AbstractThe role of NETosis and its related molecules remains unclear in gastric cancer. The data used in this study was directly downloaded from the Cancer Genome Atlas (TCGA) database. All analysis and plots are completed in R software using diverse R packages. In our study, we collected the list of NETosis‐related genes from previous publications. Based on the list and expression profile of gastric cancer patients from the TCGA database, we identified the NETosis‐related genes significantly correlated with patients survival. Then, CLEC6A, BST1 and TLR7 were identified through LASSO regression and multivariate Cox regression analysis for prognosis model construction. This prognosis model showed great predictive efficiency in both training and validation cohorts. We noticed that the high‐risk patients might have a worse survival performance. Next, we explored the biological enrichment difference between high‐ and low‐risk patients and found that many carcinogenic pathways were upregulated in the high‐risk patients. Meanwhile, we investigated the genomic instability, mutation burden and immune microenvironment difference between high‐ and low‐risk patients. Moreover, we noticed that low‐risk patients were more sensitive to immunotherapy (85.95% vs. 56.22%). High‐risk patients were more sensitive to some small molecules compounds like camptothecin_1003, cisplatin_1005, cytarabine_1006, nutlin‐3a (−)_1047, gemcitabine_1190, WZ4003_1614, selumetinib_1736 and mitoxantrone_1810. In summary, our study comprehensively explored the role of NETosis‐related genes in gastric cancer, which can provide direction for relevant studies.
Pathways: A guide for developing culturally safe and appropriate patient‐reported outcome (PROMs) and experience measures (PREMs) with Indigenous peoples
Authors: d'Agincourt‐Canning Lori , Ziabakhsh Shabnam , Morgan Jenny , Jinkerson‐Brass Elder Sharon , Joolaee Soudabeh , Smith Tonya , Loft Shelby , Rosalie Darci 
Published: December 2023

AbstractBackgroundMembers of the Indigenous Health Program, BC Children's and Women's Hospitals and the University of British Columbia embarked on a joint project to describe best practices to support the creation of patient‐reported outcome measures (PROMs) and patient‐reported experience measures (PREMs) with Indigenous peoples.MethodsThe project involved a review of previous research on patient‐reported measures (surveys) that had been specifically developed for Indigenous populations. It also involved interviews with key stakeholders—Indigenous and non‐Indigenous academic researchers, and Indigenous community leaders and community members. Themes from the interviews and the literature review were combined and synthesized into pathways/a framework for survey development.ResultsThe pathways document consisted of 13 protocols and associated teachings for guiding processes and framing survey questions. These encompassed building relationships, community engagement and consultation, benefits to community, ceremony and storytelling, two‐way learning, participatory content development, governance and accountability. Findings emphasized the criticality of Indigenous leadership in setting priorities for PROMs and PREMS and establishing relationships that honour Indigenous experiences through all phases of a study. Assessment of the framework's validity with select research participants and the Project Advisory Committee was positive.ConclusionThis is the first framework to guide development of PROMs and PREMs with Indigenous peoples and communities. It addresess both process and outcome and includes concrete steps that collaborators can take when establishing a partnership that is respectful and inclusive of Indigenous ways of knowing and being.
Molecular quantification of parasitic sea louse larvae depends on species and life stage
Authors: Mertz Nathan E. , Paterson Rachel A. , Finstad Bengt , Brandsegg Hege , Andersskog Ida Pernille Øystese , Fossøy Frode 
Published: December 2023

AbstractSea lice cause substantial economic and environmental harm to Norway's aquaculture industry and wild salmonid populations. Rapid, accurate quantification of lice larval densities in coastal waters remains the greatest bottleneck for providing empirical data on infestation risk within wild salmon habitats and aquaculture production regions. We evaluated the capability of droplet digital PCR (ddPCR) as an absolute quantification method for the planktonic stages of two parasitic louse species, Lepeophtheirus salmonis (Krøyer) and Caligus elongatus (von Nordman). Results demonstrated linear relationships between the DNA quantity measured and the number of spiked larvae for both species and life stages. However, L. salmonis contained a significantly greater number of DNA copies than C. elongatus individuals and for C. elongatus, nauplii displayed a significantly higher number of DNA copies than copepodids. Our results suggest that ddPCR can effectively enumerate louse larvae, but interpreting ddPCR results differ between the two louse species. Obtaining larval abundance estimates from marine plankton samples will depend on the nauplii to copepodid ratio for C. elongatus, but not for L. salmonis.