bluuebunny/crossref_metadata_2025_split huggingface dataset:
RİTÜELDEN OYUNA UYGUR ÇOCUK OYUNLARI
Authors: GÖNEL SÖNMEZ Tugba 
Published: December 2023

Ritüeller, bir toplum veya grup içerisinde, belirli dönemlerde belirli bir sıra ile çeşitli jest, sembol, davranış veya etkinliklerin tekrarlandığı, dinî veya dindışı bir anlam ve amaç doğrultusunda gerçekleştirilen geleneksel uygulamalardır. Bu amaçlar arasında dinî ibadet, törensel kutlamalar, geçiş ritüelleri, toplumsal birliği güçlendirme ve koruma, halk hekimliği veya büyüsel uygulamalar gibi çeşitli sosyal ve kutsal zaman etkinlikleri yer almaktadır. Dolayısıyla ritüeller, genellikle toplum tarafından ortaklaşa icra edilir ve toplumun bir parçası olan bireyler arasında iletişimi, dayanışmayı ve bağları güçlendirir. Aynı zamanda ritüeller, bireylere aidiyet duygusu ve toplumsal kimlik kazandırır.
Yetişkin dünyasının taklidi mahiyetindeki çocuk oyunları, toplumsal yaşamın her aşamasını inceleyebilmek için önemli bir kaynak niteliğindedir. Çocuklar, gözlem güçleri, taklit yetenekleri ve güçlü bellekleri ile geçmişi koruma ve saklama konusunda etkili bir rol oynarlar. Çocuk oyunları, bilişsel, fiziksel, duyusal gelişim özellikleri, katılımcıların niteliği, niceliği ve cinsiyeti, icra bağlamı gibi birçok değişkene bağlı olarak sınıflandırılmaktadır. Belirli bir kültürel ve dinî bağlamda, sosyal yaşamın ve inanç pratiklerinin taklidinden beslenen ritüel nitelikli çocuk oyunları, toplumun bir parçası olan çocuklar tarafından her toplumda icra edilmektedir. Nitekim Uygur Türkleri tarafından gerçekleştirilen ritüeller, çocuk oyunları arasında yer bulmakta, mevsimlik törenlerde, çeşitli tabiat olaylarını karşılarken, ürün hasadı sırasında, kutsal zaman niteliğindeki bayramlar, aylar, kandil gecelerinde ve milli bayramlarda, kalabalık çocuk grupları tarafından oynanmaktadır. Yetişkinlerin evren tasavvurunun taklidi ve sembolü niteliğindeki bu oyunlar, ilk çağlardan itibaren geçirdiği değişim ve dönüşüm vasıtasıyla Uygur Türklerinin toplumsal belleğinde önemli bir sembolik değer oluşturmakla birlikte kültürel mirasın gelecek nesillere aktarılmasında önemli bir araç işlevi görürler. Çocuklar, bu oyunlar aracılığıyla Uygur kültürünün temel unsurlarını, inançlarını, yaşam tarzını ve değerlerini öğrenirler. Bu sayede toplumun ortak hafızası ve kimliği, gelecek kuşaklara aktarılır. Ritüel nitelikli çocuk oyunları, aynı zamanda çocukların sosyal becerilerini geliştirmelerine, iletişim kurma, işbirliği yapma, takım çalışması, liderlik becerileri gibi sosyal yeteneklerin kazanılmasına katkı sağlar.
Çalışmada, Uygur Türkleri arasında oynanan ritüel nitelikli çocuk oyunları, kutsal ve sosyal zaman, mekan, icra ve icracı özellikleri bağlamında ele alınmaktadır. Ayrıca ritüel karakteristikteki Uygur çocuk oyunları, klasik ve modern oyun kuramları ve oyunun toplumsal işlevi bağlamında bütüncül bir bakış açısıyla literatür taramasından elde edilen verilerle değerlendirilmektedir.
Electrochemical aptasensor fabricated by anchoring recognition aptamers and immobilizing redox probes on bipolar silica nanochannel array for reagentless detection of carbohydrate antigen 15-3
Authors: Xing Jun , Han Qianqian , Liu Jiyang , Yan Zhengzheng 
Published: December 2023

Timely, convenient, and efficient detection of carbohydrate antigen 15-3 (CA15-3) levels in serum holds significant importance in early screening, diagnostic assistance and prognosis prediction of breast cancer. The development of efficient and convenient electrochemical aptasensors with immobilized redox probes for label-free detection of CA15-3 is highly desirable. In this work, a bipolar silica nanochannel array film (bp-SNA) with two distinct functional domains including nanochannels and an outer surface was employed for the immobilization of recognition ligands and electrochemical redox probes, enabling the construction of a probe-integrated aptasensor for reagentless electrochemical detection of CA15-3. Cost-effective and readily available indium tin oxide (ITO) was used as the supporting electrode for sequential growth of a negatively charged inner layer (n-SNA) followed by a positively charged outer layer (p-SNA). The preparation process of bp-SNA is convenient. Functionalization of amino groups on the outer surface of bp-SNA was modified by aldehyde groups for covalent immobilization of recognition aptamers, further establishing the recognition interface. Within the nanochannels of bp-SNA, the electrochemical redox probe, tri (2,2′-dipyridyl) cobalt (II) (Co(bpy)32+) was immobilized, which experienced a dual effect of electrostatic attraction from n-SNA and electrostatic repulsion from p-SNA, resulting in high stability of the immobilized probes. The constructed aptasensor allowed for reagentless electrochemical detection of CA15-3 ranged from 0.001 U/mL to 500 U/mL with a low detection limit (DL), 0.13 mU/mL). The application of the constructed aptasensor for CA15-3 detection in fetal bovine serum was also validated. This sensor offers advantages of a simple and readily obtainable supporting electrode, easy bp-SNA fabrication, high probe stability and good stability.
Human vaginal microbiota colonization is regulated by female sex hormones in a mouse model
Authors: Rahman Nuzhat , Mian M. Firoz , Nazli Aisha , Kaushic Charu 
Published: December 2023

IntroductionClinically, a Lactobacillus rich vaginal microbiota (VMB) is considered optimal for reproductive outcomes, while a VMB populated by anaerobes is associated with dysbiosis and the clinical condition bacterial vaginosis (BV), which is linked to increased susceptibility to sexually transmitted infections and adverse reproductive outcomes. Mouse models that mimic eubiotic and dysbiotic VMB are currently lacking but could play a critical role in improving protective interventions.MethodsIn this study, probiotic, eubiotic, and dysbiotic models were developed in C57BL/6 mice, using probiotic strains Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, eubiotic Lactobacillus crispatus, or dysbiotic Gardnerella vaginalis strains. Endogenous sex hormones were manipulated by either ovariectomizing (OVX) mice or administering 17β-estradiol or progesterone pellets in OVX mice. Hormone-altered mice were inoculated with probiotic Lactobacillus species, L. crispatus, or G. vaginalis, and colonization was tracked using quantitative plating assays. Glycogen and MUC-1 levels in hormone-treated mice were determined with ELISA and MUC-1 staining.ResultsFollowing a single administration, L. rhamnosus and L. reuteri persisted in the mouse vaginal tract for up to eight days, L. crispatus persisted for up to three days, and G. vaginalis persisted for up to two days, as measured by quantitative plating assays and qPCR. Colonization of G. vaginalis was facilitated by the presence of mucin. The lack of endogenous hormones in OVX mice dramatically decreased VMB bacterial load compared to normal mice. None of the exogenous bacteria including Lactobacilli could colonize OVX mice for more than 24 hours. Treatment with 17β-estradiol but not progesterone restored the endogenous VMB and colonization with Lactobacilli and G. vaginalis. Interestingly, 17β-estradiol treated mice had significantly increased levels of glycogen compared to OVX and progesterone-treated mice. DiscussionBased on the results, we have shown that estrogen played a significant role in the ability for human VMB species to colonize in our mouse models, potentially through a glycogen mediated mechanism. These results suggest there is a dynamic interaction between sex hormones and the VMB, which can affect bacterial diversity and the ability for a VMB to colonize.
Permafrost trapped natural gas in Svalbard, Norway
Authors: Birchall Thomas , Jochmann Malte , Betlem Peter , Senger Kim , Hodson Andrew , Olaussen Snorre 
Published: December 2023

Permafrost is widespread in the High Arctic, including the Norwegian archipelago of Svalbard. The uppermost permafrost intervals have been well studied, but the processes at its base and the impacts of the underlying geology have been largely overlooked. More than a century of coal, hydrocarbon, and scientific drilling through the permafrost in Svalbard shows that accumulations of natural gas trapped at the base of permafrost are common. These accumulations exist in several stratigraphic intervals throughout Svalbard and show both thermogenic and biogenic origins. The gas, combined with the relatively young permafrost age, is evidence of ongoing gas migration throughout Svalbard. The accumulation sizes are uncertain, but one case demonstrably produced several million cubic metres of gas over 8 years. Heavier gas encountered in two boreholes on Hopen may be situated in the gas hydrate stability zone. While permafrost is demonstrably ice-saturated and acting as seal to gas in lowland areas, in the highlands permafrost is more complex and often dry and permeable. Svalbard shares a similar geological and glacial history with much of the Circum-Arctic, suggesting that sub-permafrost gas accumulations are regionally common. With permafrost thawing in the Arctic, there is a risk that the impacts of releasing of methane trapped beneath permafrost will lead to positive climatic feedback effects.
The negative impact of levothyroxine treatment on urinary luteinizing hormone measurements in pediatric patients with thyroid disease
Authors: Demir And , Böber Ece , Darcan Sükran , Aydın Adem , Stenman Ulf-Håkan , Büyükgebiz Atilla , Hero Matti 
Published: December 2023

ObjectivesPrevious studies suggest urinary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements by immunofluorometric assays (IFMA) as noninvasive alternatives to serum assays for puberty assessment. However, these studies excluded patients with other endocrine disorders and those taking medications. Besides, the recent discontinuation of IFMA manufacturing is a concern. We explored the utility of luminometric assays (LIA) for urinary gonadotropins and thyroid-stimulating hormone (TSH) determinations in euthyroid patients with thyroid pathologies.MethodsWe used LIA and IFMA assays to measure serum and first-morning-voided (FMV) urine LH, FSH, and TSH concentrations in euthyroid patients with various thyroid disorders. Of the 47 euthyroid patients with normal serum TSH (S-TSH) levels, 14 were receiving levothyroxine therapy.ResultsFMV total urinary LH (U-LH) concentrations correlated significantly with those measured in serum using either LIA (r=0.67, P&lt;.001) or IFMA (r=0.83, P=.003) in patients not receiving levothyroxine treatment; however, no significant correlation could be detected in patients receiving levothyroxine regardless of the assay method (for LIA: r=0.50, P=.08 and IFMA r=0.44, P=.15). Urinary TSH (U-TSH) concentrations correlated poorly with those in serum in both the untreated and the treated groups (r=-0.13, P=.49, and r=-0.45, P=.11, respectively).ConclusionFMV total U-LH determinations by LIA can be used to assess pubertal development in patients with thyroid pathology, provided the euthyroid patient is not on levothyroxine treatment. U-TSH measurements by LIA cannot replace invasive S-TSH measurements at least in patients with normal S-TSH levels. Further research may reveal the utility of U-TSH determinations in patients with elevated S-TSH levels.
Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study
Authors: Li Ruiqi , Wang Yukun , Yang Lin , Zhong Ping , Huang Gongchen , Liang Qiulian , Yu Xiangyuan 
Published: December 2023

IntroductionGestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of mothers and their offspring. So far, the etiology has not been fully clarified.MethodsA case-control study was conducted to clarify the relationship between Erb-b2 receptor tyrosine kinase 4 (ERBB4) functional tag genetic variants (rs1595064, rs1595065, rs1595066 and rs6719645) and the risk of GDM. Associations between variants and GDM risk were evaluated with the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Subsequently, the false-positive reporting probability (FPRP), multi-factor dimension reduction (MDR) and bioinformatics analysis were adopted to confirm the significant associations. A nomogram model was constructed to predict the risk of GDM.ResultsAssociation analysis demonstrated that rs1595066 TT genotype performed a protective effect on GDM risk among all subjects (TT vs. CC: adjusted OR = 0.60, 95% CI = 0.38 - 0.94, P = 0.026; TT vs. CC/CT: adjusted OR = 0.61, 95% CI = 0.40 - 0.95, P = 0.027). Meanwhile, stratified analysis showed that rs1595066 TT can also reduce the GDM risk in age &gt; 30.09 years old, pre-pregnancy BMI &gt; 22.23 Kg/m2, SBP ≤ 110.08 mmHg, etc subgroups. Interactions between rs1595066 and DBP (Pinteraction = 0.01), FPG (Pinteraction &lt; 0.001) and HbA1c (Pinteraction &lt; 0.001) were detected. The FPRP analysis confirmed that association between rs1595066 and GDM risk in subjects of FPG &lt; 4.79 mmol/L (P = 0.199) is true. The MDR analysis showed that rs1595066 was the best single locus model while the 4-loci model was the best multiple factors model to predict GDM risk. Functional prediction revealed that rs1595066 may disturb the stability of miRNA-mRNA binding. The predictive nomogram model has a well consistence and acceptable discriminative ability with a diagnosed AUC of 0.813.DiscussionERBB4 variants can change an individual’s susceptibility to GDM via the interaction of gene-gene, gene-environment and changes in the regulatory effects of miRNAs on ERBB4 expression.
The effect of ovarian injection of autologous platelet rich plasma in patients with poor ovarian responder: a systematic review and meta-analysis
Authors: Li Xuanling , Liu Huicong , Lin Guangyao , Xu Lianwei 
Published: December 2023

ObjectiveTo evaluate the effects of ovarian injection of autologous platelet rich plasma (aPRP) on patients with poor ovarian responder (POR) based on the existing clinical evidence.MethodsAccording to systematic review and meta-analysis, we comprehensively searched nine databases established as of September 6, 2023, and evaluated the impact of ovarian PRP infusion on poor ovarian responder. The research results include serum follicle-stimulating hormone(FSH) and anti-Mullerian hormone(AMH) levels, antral Follicle Count(AFC), oocyte number, and embryo number. The Newcastle Ottawa Scale (NOS) was used to evaluate the quality of inclusion in trials.ResultsAdd up to 10 studies consisting of 793 participants were included in the meta-analysis. A review of existing evidence showed that intraovarian injection of PRP has significant therapeutic effects in increasing levels of anti-Müllerian hormone (AMH) (SMD=0.44,95% CI [0.07,0.81], p=0.02), antral follicle count (AFC) (MD=1.15,95% CI [0.4,1.90], p=0.003), oocyte count (MD=0.91, 95% CI [0.40, 1.41], p=0.0004), and embryo number (MD=0.78, 95% CI [0.5,1.07], p&lt;0.0001). We compared the relevant data of patients before and after treatment after 2 months of intervention. It can be seen that ovarian injection of PRP treatment for 2 months has better effects in reducing FSH levels, increasing AMH levels, increasing antral follicle count, and increasing the number of oocytes and embryos (p&lt;0.05). When the dose of PRP injected into each ovary was ≥ 4ml, there was also a significant correlation (p&lt;0.05) with improving the number of AFC, oocytes and embryos. Significant heterogeneity existed among the studies.ConclusionThe pooled results suggest that intra-ovarian injection of PRP can promote ovarian regeneration and improve the reproductive outcomes of patients with ovarian dysfunction. This therapy may have significant clinical potential in improving sex hormone levels, increasing AFC, oocyte count, and embryo count. However, this findings still requires more rigorous and extensive trials worldwide to determine the value of intra-ovarian injection of PRP in POR patients.Systematic review registrationhttps://www.crd.york.ac.uk, Identifier CRD42023451232.
Pubertal attainment and Leydig cell function following pediatric hematopoietic stem cell transplantation: a three-decade longitudinal assessment
Authors: Cattoni Alessandro , Nicolosi Maria Laura , Capitoli Giulia , Gadda Alberto , Molinari Silvia , Louka Sotiris , Buonsante Andrea , Orlandi Simona , Salierno Gianluca , Bellani Iacopo , Vendemini Francesca , Ottaviano Giorgio , Gaiero Alberto , Fichera Graziella , Biondi Andrea , Balduzzi Adriana 
Published: December 2023

IntroductionImpaired testosterone secretion is a frequent sequela following hematopoietic stem cell transplantation (HSCT) in pediatrics, but long-term longitudinal trendlines of clinical and biochemical findings are still scanty.MethodsMonocentric, retrospective analysis. Male patients transplanted &lt;18 years between 1992 and 2021, surviving ≥2 years after HSCT and showing, upon enrollment, clinical and biochemical signs consistent with pubertal onset and progression were included. Clinical and biochemical data collected every 6-12 months were recorded.ResultsOf 130 patients enrolled, 56% were prepubertal, while 44% were peri-/postpubertal upon HSCT. Overall, 44% showed spontaneous progression into puberty and normal gonadal profile, while the remaining experienced pubertal arrest (1%), isolated increase of FSH (19%), compensated (23%) or overt (13%) hypergonadotropic hypogonadism. Post-pubertal testicular volume (TV) was statistically smaller among patients still pre-pubertal upon HSCT (p 0.049), whereas no differences were recorded in adult testosterone levels. LH and testosterone levels showed a specular trend between 20 and 30 years, as a progressive decrease in sexual steroids was associated with a compensatory increase of the luteinizing hormone. A variable degree of gonadal dysfunction was reported in 85%, 51%, 32% and 0% of patients following total body irradiation- (TBI), busulfan-, cyclophosphamide- and treosulfan-based regimens, respectively. TBI and busulfan cohorts were associated with the lowest probability of gonadal event-free course (p&lt;0.0001), while it achieved 100% following treosulfan. A statistically greater gonadotoxicity was detected after busulfan than treosulfan (p 0.024). Chemo-only regimens were associated with statistically larger TV (p &lt;0.001), higher testosterone (p 0.008) and lower gonadotropin levels (p &lt;0.001) than TBI. Accordingly, the latter was associated with a 2-fold increase in the risk of gonadal failure compared to busulfan (OR 2.34, CI 1.08-8.40), whereas being pre-pubertal upon HSCT was associated with a reduced risk (OR 0.15, CI 0.08-0.30).Conclusionsa) patients pre-pubertal upon HSCT showed a reduced risk of testicular endocrine dysfunction, despite smaller adult TV; b) patients showed downwards trend in testosterone levels after full pubertal attainment, despite a compensatory increase in LH; c) treosulfan was associated to a statistically lower occurrence of hypogonadism than busulfan, with a trend towards larger TV, higher testosterone levels and lower gonadotropins.
Non-linear association of triglyceride-glucose index with prevalence of prediabetes and diabetes: a cross-sectional study
Authors: Zhang Linhao , Zeng Ling 
Published: December 2023

BackgroundThe Triglyceride-glucose (TyG) index has been acknowledged as a convenient, cost-effective, and relatively simple marker for insulin resistance (IR). Meanwhile, prediabetes, described as an asymptomatic, moderately hyperglycemic state, tends to be more prevalent than diabetes. Thus, the objective of this study was to explore the relationship between the TyG index and the prevalence of both prediabetes and diabetes within the U.S. population.MethodsThis study utilized a cross-sectional dataset derived from the National Health and Nutrition Survey (NHANES) spanning 1999 to 2018. The subjects were individuals aged 18 years and above, who had available fasting glucose and fasting triglyceride information, permitting a diagnosis of prediabetes or diabetes. The TyG index was computed using laboratory data, and participants were subsequently categorized into quartiles based on this information. The relationship between the TyG index and the prevalence of prediabetes and diabetes was investigated using logistic regression analysis.ResultsOut of the 25,159 participants, 23.88% were found to have prediabetes, while 16.22% were diagnosed with diabetes. After adjusting for confounding factors, a linear increase in relative odds was observed in Q2 (OR: 1.69; 95% CI: 1.52, 1.89), Q3 (OR: 2.57; 95% CI: 2.30, 2.88), and Q4 (OR: 4.88; 95% CI: 4.33, 5.49) groups in comparison to the reference group, Q1. In addition, a non-linear relationship was observed between the TyG index and the prevalence of prediabetes and diabetes. Specifically, patients with a TyG index greater than 8.00 overall exhibited a significantly higher risk of prediabetes and diabetes, confirming that an increase in the TyG index is associated with a corresponding increase in risk. However, this shift showed gender-specific variations; the threshold was observed at 8.00 in males but shifted to 9.00 in females.ConclusionThe TyG index demonstrated a non-linear positive correlation with both prediabetes and diabetes. This suggests that maintaining the TyG index at a certain, reduced level could potentially aid in preventing the onset of prediabetes and diabetes.
The comparison between fixed versus degressive doses of medroxyprogesterone acetate combined with letrozole in patients of progestin-primed ovarian stimulation protocol: a propensity score-matched study
Authors: Zhang Ying , Li Hao , Zhu Shanshan , Jiang Shengfang , Zhao Wenxian , Wang Xiaoning , Tian Liu , Zhao Guangming , He Nongqiao , Diao Honglu , Cao Hong , Zhang Changjun 
Published: December 2023

ObjectiveTo explore the cycle characteristics and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) using fixed versus degressive doses of medroxyprogesterone acetate (MPA) in conjunction with letrozole (LE) in infertile women by propensity score matching (PSM) analysis.DesignA retrospective cohort study.SettingTertiary-care academic medical center.PopulationA total of 3173 infertile women undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment within the period from January 2017 to December 2020.MethodsA total of 1068 and 783 patients who underwent a fixed dose of MPA combined with LE and a degressive dose of MPA combined with LE protocols, respectively, were enrolled in this study. The freeze-all approach and later frozen-thawed embryo transfer (FET) were performed in both groups. Propensity score matching (1:1) was performed.Main outcome measuresThe primary outcomes were the dosage of MPA and the incidence of premature luteinizing hormone (LH) surges. The secondary outcomes were the number of oocytes retrieved, the cumulative live birth rate (CLBR) and the fetal malformation rate.ResultsWe created a perfect match of 478 patients in each group. The dosage of MPA, the LH serum level on the eighth day of stimulation, progesterone (P) level and LH level on the hCG trigger day were significantly higher in the LE + fixed MPA group than in the LE + degressive MPA group (52.1 ± 13.1 mg vs. 44.9 ± 12.5 mg; 5.0 ± 2.7 IU/L vs. 3.7 ± 1.7 IU/L; 0.9 ± 0.5 ng/ml vs. 0.8 ± 0.5 ng/ml; 3.3 ± 2.4 IU/L vs. 2.8 ± 1.9 IU/L; P &lt; 0.01). The duration of Gn, the number of follicles with diameter more than 16 mm on trigger day, the estradiol (E2) level on the hCG trigger day were lower in the LE + fixed MPA group than in the LE + degressive MPA group (9.7 ± 1.7 days vs. 10.3 ± 1.5 days; 5.6 ± 3.0 vs. 6.3 ± 3.0; 1752.5 ± 1120.8 pg/ml vs. 1997.2 ± 1108.5 pg/ml; P &lt; 0.001). No significant difference was found in the incidence of premature LH surge, the number of oocytes retrieved, the number of top-quality embryos, clinical pregnancy rate (CPR), CLBR or fetal malformation rate between the two groups.ConclusionThe combination of a degressive MPA dose with LE proved effective in reducing the total MPA dosage with comparable premature LH surge and pregnancy outcomes in women undergoing the PPOS protocol.