bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma
Authors: Zhou Jian Ping , Wang Yi , Li Shi Qi , Zhang Jia Qi , Lin Ying Ni , Sun Xian Wen , Zhou Li Na , Zhang Liu , Lu Fang Ying , Ding Yong Jie , Li Qing Yun 
Published: October 2023

AbstractObstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in severe asthma. However, the extent of autophagy’s involvement in CIH-potentiated airway remodelling remains largely unexplored. Furthermore, we had found that angiotensin-(1-7) [Ang-(1-7)] has therapeutic effects on airway remodelling in asthma, but the underlying mechanism is either unclear. This study aimed to explore how CIH aggravates asthma and mechanism of protective effects of Ang-(1-7) on airway remodelling, with a focus on autophagy. We observed that CIH promoted epithelial-to-mesenchymal transition (EMT), indicated by elevated EMT and fibrotic markers such as Snail and Collagen IV, both in vitro and in vivo. CIH intensified cell autophagy, evident from increased LC3B expression and reduced p62 levels. Ang-(1-7) reversed the CIH-enhanced expression of Snail, Collagen IV, and LC3B. To explore how CIH enhanced autophagy in cellular and animal model of asthma, overexpression of hypoxia-inducible factor 1-alpha (HIF-1α) and Thrombospondin 1 (THBS1) were identified in CIH-exposure mice lung compared with normal mice lung tissues from the GEO database. Finally, through chromatin immunoprecipitation and immunoprecipitation assays, we verified that Ang-(1-7) inhibits CIH-induced binding of HIF-1α to the promoter of THBS1, and also disrupts the protein-protein interaction between THBS1 and the autophagy-associated protein Beclin 1 (BECN1), ultimately leading to autophagy inhibition. Our findings suggest that exogenous Ang-(1-7) can inhibit autophagy via HIF-1α/THBS1/BECN1 axis, thereby alleviating CIH-enhanced airway remodelling in asthma. These findings imply the potential therapeutic effect of Ang-(1-7) in asthma with OSA.
2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring
Authors: Levterov Vadym V. , Panasiuk Yaroslav , Sahun Kateryna , Stashkevych Oleksandr , Badlo Valentyn , Shablykin Oleh , Sadkova Iryna , Bortnichuk Lina , Klymenko-Ulianov Oleksii , Holota Yuliia , Lachmann Leonid , Borysko Petro , Horbatok Kateryna , Bodenchuk Iryna , Bas Yuliia , Dudenko Dmytro , Mykhailiuk Pavel K. 
Published: October 2023

AbstractThe phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the structure is based on the analysis of the advantages and disadvantages of the previously used bioisosteres: bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane, and cubane. The key synthesis step is the iodocyclization of cyclohexane-containing alkenyl alcohols with molecular iodine in acetonitrile. 2-Oxabicyclo[2.2.2]octane core is incorporated into the structure of Imatinib and Vorinostat (SAHA) drugs instead of the phenyl ring. In Imatinib, such replacement leads to improvement of physicochemical properties: increased water solubility, enhanced metabolic stability, and reduced lipophilicity. In Vorinostat, such replacement results in a new bioactive analog of the drug. This study enhances the repertoire of available saturated bioisosteres of (hetero)aromatic rings for the use in drug discovery projects.
Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence
Authors: Reeves Daniel B. , Bacchus-Souffan Charline , Fitch Mark , Abdel-Mohsen Mohamed , Hoh Rebecca , Ahn Haelee , Stone Mars , Hecht Frederick , Martin Jeffrey , Deeks Steven G. , Hellerstein Marc K. , McCune Joseph M. , Schiffer Joshua T. , Hunt Peter W. 
Published: October 2023

AbstractPersistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (TTM), and effector-memory (TEM). HIV decreases in TTM and TEM but not in less-differentiated subsets. Cell turnover is ~10 times faster than HIV clearance in memory subsets, implying that cellular proliferation consistently creates HIV DNA. The optimal mathematical model for these integrated data sets posits HIV DNA also passages between CD4 cell subsets via cellular differentiation. Estimates are heterogeneous, but in an average participant’s year ~10 (in TN and TSCM) and ~104 (in TCM, TTM, TEM) proviruses are generated by proliferation while ~103 proviruses passage via cell differentiation (per million CD4). In simulations, therapies blocking proliferation and/or enhancing differentiation could reduce HIV DNA by 1-2 logs over 3 years. In summary, HIV exploits cellular proliferation and differentiation to persist during ART but clears faster in more proliferative/differentiated CD4 cell subsets and the same physiological mechanisms sustaining HIV might be temporarily modified to reduce it.
Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases
Authors: Zhang Peisen , Cheng Junwei , Lu Yijie , Zhang Ni , Wu Xiaoai , Lin Hua , Li Wei , Wang Jian , Winnik Mitchell A. , Gan Zhihua , Hou Yi 
Published: October 2023

AbstractMagnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.
Unchanged frequency and decreasing magnitude of outbursts from ice-dammed lakes in Alaska
Authors: Rick B. , McGrath D. , McCoy S. W. , Armstrong W. H. 
Published: October 2023

AbstractGlacial lakes can form and grow due to glacial retreat, and rapid lake drainage can produce destructive floods. Outburst flood compilations show a temporal increase in frequency; however, recent studies highlight the role of observational bias, creating uncertainty about current and future glacial-lake hazards. Here, we focus on the Alaska region, which generated a third of previously documented outbursts globally. Using multitemporal satellite imagery, we documented 1150 drainages from 106 ice-dammed lakes between 1985 and 2020. Documented events became more frequent over time, however, accounting for increasing image availability reveals no significant increase occurred. Most lakes decreased in area and volume, suggesting a reduction in regional flood hazard. Our satellite-based approach documented 60% more events in a 35-year period than had previously been documented over 100 years. This suggests that outburst floods have historically been underreported and warrants systematic study of other regions.
Sustainably developing global blue carbon for climate change mitigation and economic benefits through international cooperation
Authors: Feng Cuicui , Ye Guanqiong , Zeng Jiangning , Zeng Jian , Jiang Qutu , He Liuyue , Zhang Yaowen , Xu Zhenci 
Published: October 2023

AbstractBlue carbon is the carbon storage in vegetated coastal ecosystems such as mangroves, salt marshes, and seagrass. It is gaining global attention as its role in climate change mitigation and local welfare growth. However, a global assessment on the long-term spatiotemporal sustainable development status of blue carbon has not been conducted, and the relations among blue carbon ecosystems, driving forces for climate change mitigation, and socioeconomic interventions for development capacity on a global scale are still unclear. Here, we constructed a blue carbon development index (BCDI), comprising three subsystems: driving force, resource endowment, and development capacity, to assess the sustainable development level of 136 coastal countries’ blue carbon over 24 consecutive years and explore the relationship among subsystems. We further propose a cooperation model to explore the feasibility of global blue carbon cooperation and quantify benefit allocation to specific countries. The results showed an upward trend in BCDI scores with variations in regional performance over the past two decades, and we found a positive correlation between development capacity and blue carbon resource endowment. Based on the scenario simulations of global cooperation, we found that coastal countries could improve the global average BCDI score, add 2.96 Mt of annual carbon sequestration, and generate $136.34 million in 2030 under Global Deep Cooperation scenario compared with the Business-As-Usual scenario.
NaRuO2: Kitaev-Heisenberg exchange in triangular-lattice setting
Authors: Bhattacharyya Pritam , Bogdanov Nikolay A. , Nishimoto Satoshi , Wilson Stephen D. , Hozoi Liviu 
Published: October 2023

AbstractKitaev exchange, a new paradigm in quantum magnetism research, occurs for 90° metal-ligand-metal links, $${t}_{2g}^{5}$$

t

2
g

5

transition ions, and sizable spin-orbit coupling. It is being studied in honeycomb compounds but also on triangular lattices. While for the former it is known by now that the Kitaev intersite couplings are ferromagnetic, for the latter the situation is unclear. Here we pin down the exchange mechanisms and determine the effective coupling constants in the $${t}_{2g}^{5}$$

t

2
g

5

triangular-lattice material NaRuO2, recently found to host a quantum spin liquid ground state. We show that, compared to honeycomb compounds, the characteristic triangular-lattice cation surroundings dramatically affect exchange paths and effective coupling parameters, changing the Kitaev interactions to antiferromagnetic. Quantum chemical analysis combined with subsequent effective spin model simulations provide perspective onto the nature of the experimentally observed quantum spin liquid—it seemingly implies fairly large antiferromagnetic second-neighbor isotropic exchange, and the atypical proximity to ferromagnetic order is related to ferromagnetic nearest-neighbor Heisenberg coupling.
Widespread small grabens consistent with recent tectonism on Mercury
Authors: Man Benjamin , Rothery David A. , Balme Matthew R. , Conway Susan J. , Wright Jack 
Published: October 2023

AbstractSince Mariner 10 first imaged Mercury in 1974, tectonic landforms dominated by shortening structures have been extensively documented. Contractional tectonism on Mercury is thought to have begun early in the planet’s history and is theorized to have continued throughout Mercury’s geological history, but observational evidence for recent tectonism is limited. Here we report the widespread occurrence of relatively young grabens on Mercury from global mapping of tectonic features using MESSENGER imagery. The identified grabens are about 10 to 150 m deep, tens of kilometres in length and generally less than 1 km wide. We find that the grabens occur as secondary tectonic features on larger compressional tectonic structures, which indicates continued activity of the parent structure. We estimate that they must be ~300 million years old or younger; otherwise, impact gardening would have masked their signature by burial and infilling. The widespread distribution of grabens and their young age supports the continued activity of Mercury’s shortening structures into geologically recent times and is consistent with thermochemical evolution models for a slowly cooling planetary interior and prolonged global contraction.
The positive–negative–competence (PNC) model of psychological responses to representations of robots
Authors: Krpan Dario , Booth Jonathan E. , Damien Andreea 
Published: October 2023

AbstractRobots are becoming an increasingly prominent part of society. Despite their growing importance, there exists no overarching model that synthesizes people’s psychological reactions to robots and identifies what factors shape them. To address this, we created a taxonomy of affective, cognitive and behavioural processes in response to a comprehensive stimulus sample depicting robots from 28 domains of human activity (for example, education, hospitality and industry) and examined its individual difference predictors. Across seven studies that tested 9,274 UK and US participants recruited via online panels, we used a data-driven approach combining qualitative and quantitative techniques to develop the positive–negative–competence model, which categorizes all psychological processes in response to the stimulus sample into three dimensions: positive, negative and competence-related. We also established the main individual difference predictors of these dimensions and examined the mechanisms for each predictor. Overall, this research provides an in-depth understanding of psychological functioning regarding representations of robots.
The high optical brightness of the BlueWalker 3 satellite
Authors: Nandakumar Sangeetha , Eggl Siegfried , Tregloan-Reed Jeremy , Adam Christian , Anderson-Baldwin Jasmine , Bannister Michele T. , Battle Adam , Benkhaldoun Zouhair , Campbell Tanner , Colque J. P. , Damke Guillermo , Plauchu Frayn Ilse , Ghachoui Mourad , Guillen Pedro F. , Kaeouach Aziz Ettahar , Krantz Harrison R. , Langbroek Marco , Rattenbury Nicholas , Reddy Vishnu , Ridden-Harper Ryan , Young Brad , Unda-Sanzana Eduardo , Watson Alan M. , Walker Constance E. , Barentine John C. , Benvenuti Piero , Di Vruno Federico , Peel Mike W. , Rawls Meredith L. , Bassa Cees , Flores-Quintana Catalina , García Pablo , Kim Sam , Longa-Peña Penélope , Ortiz Edgar , Otarola Ángel , Romero-Colmenares María , Sanhueza Pedro , Siringo Giorgio , Soto Mario 
Published: October 2023

AbstractLarge constellations of bright artificial satellites in low Earth orbit pose significant challenges to ground-based astronomy1. Current orbiting constellation satellites have brightnesses between apparent magnitudes 4 and 6, whereas in the near-infrared Ks band, they can reach magnitude 2 (ref. 2). Satellite operators, astronomers and other users of the night sky are working on brightness mitigation strategies3,4. Radio emissions induce further potential risk to ground-based radio telescopes that also need to be evaluated. Here we report the outcome of an international optical observation campaign of a prototype constellation satellite, AST SpaceMobile’s BlueWalker 3. BlueWalker 3 features a 64.3 m2 phased-array antenna as well as a launch vehicle adaptor (LVA)5. The peak brightness of the satellite reached an apparent magnitude of 0.4. This made the new satellite one of the brightest objects in the night sky. Additionally, the LVA reached an apparent V-band magnitude of 5.5, four times brighter than the current International Astronomical Union recommendation of magnitude 7 (refs. 3,6); it jettisoned on 10 November 2022 (Universal Time), and its orbital ephemeris was not publicly released until 4 days later. The expected build-out of constellations with hundreds of thousands of new bright objects1 will make active satellite tracking and avoidance strategies a necessity for ground-based telescopes.
Early detection of autism using digital behavioral phenotyping
Authors: Perochon Sam , Di Martino J. Matias , Carpenter Kimberly L. H. , Compton Scott , Davis Naomi , Eichner Brian , Espinosa Steven , Franz Lauren , Krishnappa Babu Pradeep Raj , Sapiro Guillermo , Dawson Geraldine 
Published: October 2023

AbstractEarly detection of autism, a neurodevelopmental condition associated with challenges in social communication, ensures timely access to intervention. Autism screening questionnaires have been shown to have lower accuracy when used in real-world settings, such as primary care, as compared to research studies, particularly for children of color and girls. Here we report findings from a multiclinic, prospective study assessing the accuracy of an autism screening digital application (app) administered during a pediatric well-child visit to 475 (17–36 months old) children (269 boys and 206 girls), of which 49 were diagnosed with autism and 98 were diagnosed with developmental delay without autism. The app displayed stimuli that elicited behavioral signs of autism, quantified using computer vision and machine learning. An algorithm combining multiple digital phenotypes showed high diagnostic accuracy with the area under the receiver operating characteristic curve = 0.90, sensitivity = 87.8%, specificity = 80.8%, negative predictive value = 97.8% and positive predictive value = 40.6%. The algorithm had similar sensitivity performance across subgroups as defined by sex, race and ethnicity. These results demonstrate the potential for digital phenotyping to provide an objective, scalable approach to autism screening in real-world settings. Moreover, combining results from digital phenotyping and caregiver questionnaires may increase autism screening accuracy and help reduce disparities in access to diagnosis and intervention.
An integrated pipeline for prediction of Clostridioides difficile infection
Authors: Li Jiang , Chaudhary Durgesh , Sharma Vaibhav , Sharma Vishakha , Avula Venkatesh , Ssentongo Paddy , Wolk Donna M. , Zand Ramin , Abedi Vida 
Published: October 2023

AbstractWith the expansion of electronic health records(EHR)-linked genomic data comes the development of machine learning-enable models. There is a pressing need to develop robust pipelines to evaluate the performance of integrated models and minimize systemic bias. We developed a prediction model of symptomatic Clostridioides difficile infection(CDI) by integrating common EHR-based and genetic risk factors(rs2227306/IL8). Our pipeline includes (1) leveraging phenotyping algorithm to minimize temporal bias, (2) performing simulation studies to determine the predictive power in samples without genetic information, (3) propensity score matching to control for the confoundings, (4) selecting machine learning algorithms to capture complex feature interactions, (5) performing oversampling to address data imbalance, and (6) optimizing models and ensuring proper bias-variance trade-off. We evaluate the performance of prediction models of CDI when including common clinical risk factors and the benefit of incorporating genetic feature(s) into the models. We emphasize the importance of building a robust integrated pipeline to avoid systemic bias and thoroughly evaluating genetic features when integrated into the prediction models in the general population and subgroups.
Spatial extent of dysbiosis in the branching coral Pocillopora damicornis during an acute disease outbreak
Authors: Greene Austin , Moriarty Tess , Leggatt William , Ainsworth Tracy D. , Donahue Megan J. , Raymundo Laurie 
Published: October 2023

AbstractGlobally, coral reefs face increasing disease prevalence and large-scale outbreak events. These outbreaks offer insights into microbial and functional patterns of coral disease, including early indicators of disease that may be present in visually-healthy tissues. Outbreak events also allow investigation of how reef-building corals, typically colonial organisms, respond to disease. We studied Pocillopora damicornis during an acute tissue loss disease outbreak on Guam to determine whether dysbiosis was present in visually-healthy tissues ahead of advancing disease lesions. These data reveal that coral fragments with visual evidence of disease are expectedly dysbiotic with high microbial and metabolomic variability. However, visually-healthy tissues from the same colonies lacked dysbiosis, suggesting disease containment near the affected area. These results challenge the idea of using broad dysbiosis as a pre-visual disease indicator and prompt reevaluation of disease assessment in colonial organisms such as reef-building corals.
Movement-related tactile gating in blindness
Authors: Casado-Palacios Maria , Tonelli Alessia , Campus Claudio , Gori Monica 
Published: October 2023

AbstractWhen we perform an action, self-elicited movement induces suppression of somatosensory information to the cortex, requiring a correct motor-sensory and inter-sensory (i.e. cutaneous senses, kinesthesia, and proprioception) integration processes to be successful. However, recent works show that blindness might impact some of these elements. The current study investigates the effect of movement on tactile perception and the role of vision in this process. We measured the velocity discrimination threshold in 18 sighted and 18 blind individuals by having them perceive a sequence of two movements and discriminate the faster one in passive and active touch conditions. Participants’ Just Noticeable Difference (JND) was measured to quantify their precision. Results showed a generally worse performance during the active touch condition compared to the passive. In particular, this difference was significant in the blind group, regardless of the blindness duration, but not in the sighted one. These findings suggest that the absence of visual calibration impacts motor-sensory and inter-sensory integration required during movement, diminishing the reliability of tactile signals in blind individuals. Our work spotlights the need for intervention in this population and should be considered in the sensory substitution/reinforcement device design.
Structured multi-criteria model of self-managed motivation in organizations based on happiness at work: pandemic related study
Authors: Nieżurawska Joanna , Kycia Radosław A. , Ludviga Iveta , Niemczynowicz Agnieszka 
Published: October 2023

AbstractThis study proposes the Structured Multi-criteria Model of Self-Managed Motivation in Organizations based on happiness at work. Employees need to be motivated in order to be efficient at doing a particular task at the workplace. As young people born between 1995 and 2004, called Generation Z, enter the labour market, it is essential to consider how employees’ motivation might be affected. In the article a quantitative approach was used to collect new data from 200 Polish respondents completing an online survey. The research was conducted before and during the pandemic time. We report and analyze the survey results conducted in Poland among the representatives of Generation Z, who had been employed for at least 6 months. We developed and validated a new approach to motivation using methodologies called Factor Analysis. Based on empirical verification, we found a new tool that connects employee motivation and selected areas of the Hygge concept called Hygge Star Model, which has the same semantics before and during Covid-19 pandemic.