bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bredigite‐Based Bioactive Nerve Guidance Conduit for Pro‐Healing Macrophage Polarization and Peripheral Nerve Regeneration
Authors: Xuan Yaowei , Li Lin , Yin Xuelai , He Dongming , Li Siyao , Zhang Chenping , Yin Yuan , Xu Wanlin , Zhang Zhen 
Published: November 2023

AbstractStructural and functional healing of peripheral nerves damaged by trauma or chronic disease remain major clinical challenges, requiring the development of an effective nerve guidance conduit (NGC). The present study investigates a NGC fabrication strategy based on bredigite (BRT, Ca7MgSi4O16) bioceramic for the treatment of peripheral nerve injury. Here, BRT bioceramic shows good biocompatibility and sustainable release of Ca2+, Mg2+, and Si4+ ions. Both BRT extracts and BRT‐incorporating electrospun membranes promote the proliferation and myelination potential of RSC96 cells, as well as accelerate vascular formation by human umbilical vein endothelial cells. Notably, BRT facilitates RAW 264.7 cell polarization to the pro‐healing phenotype under LPS‐induced inflammatory stimulation. More importantly, the macrophages activated by BRT in turn promote RSC96 cell migration and remyelination. In a rat sciatic nerve defect model, improved electrophysiological performance and alleviated gastrocnemius muscle atrophy are observed at 12 weeks post‐implantation. Further experiments verify that BRT‐loaded NGC facilitates axonal regrowth and revascularization with high M2‐like macrophage infiltration. These findings support the beneficial effects of BRT for creating a pro‐healing immune microenvironment and orchestrating multicellular processes associated with functional nerve regeneration, indicating the potential of rationally engineered bioceramics as safe, effective, and economical materials for peripheral nerve repair.
Multicolor‐Tunable and Time‐Dependent Circularly Polarized Room‐Temperature Phosphorescence from Liquid Crystal Copolymers
Authors: Gong Wei , Zhou Mengdie , Xiao Lingyu , Fan Chunyan , Yuan Yongjie , Gong Yongyang , Zhang Hailiang 
Published: November 2023

AbstractCircularly polarized luminescent (CPL) materials have significant promising applications in organic light‐emitting diodes, asymmetric synthesis, and other fields. However, due to the instability of triplet‐state excitons, how to achieve an effective combination of CPL with room‐temperature phosphorescence (RTP) remains a formidable challenge. Here, a simple and feasible method for constructing polymer‐based CPRTP materials is proposed by preparing chiral phosphorescent liquid crystals through copolymerization. A series of RTP chiral liquid crystal copolymers are successfully synthesized by copolymerizing phosphorescent monomer bearing chiral cholesterol mesogen with phosphorescent monomer bearing dibenzofuran chromophore. Due to the introduction of chiral cholesterol mesogen, copolymers can form chiral smectic C‐phase liquid crystals. Utilizing their selective reflection characteristic, efficient CPRTP is achieved, with a glum value of up to −1.6 × 10−2. In addition, both components in copolymers exhibit RTP properties and show significant differences in phosphorescence color and lifetime. By changing the composition of copolymers, the regulation of their phosphorescence properties is successfully achieved. As a result, multicolor‐tunable and time‐dependent CPRTP materials are successfully prepared.
Strategies and Methods for the Catalytic Asymmetric Synthesis of Benzofuran/Benzopyran Fused Acetals: A Review
Authors: Chen Yushuang , Zhang Yulong , Zhang Dong , Wang Zhen 
Published: November 2023

AbstractBenzofuran‐ and benzopyran‐fused polycyclic acetals are found in a variety of biologically active natural products. The synthetic methods toward this class of polycyclic heterocycles have fascinated one of the most intensive pursuits in total synthesis. Nevertheless, stereoselective methods towards the rapid construction of such skeletons still remain challenging for organic chemists. Significant progress has been made in this research area in recent years, however, literature on enantioselective approaches to construct these molecules has not fully reviewed. Driven by their intriguing and complex scaffolds with potential usefulness, we compose the recent advances in this review covering all the important works in this field. We hope this review will promote future research in this area.
Resistance identification and nitrogen management of wheat under late spring coldness
Authors: Zheng Jia Cheng , Dai Han Jing , Huang Xiao Yi , Liu Yan Long , Li Jie Qin , Li Wen Yang , Zhan Qiu Wen , Hu Neng Bing , Li Jin Cai 
Published: November 2023

AbstractLate spring coldness has a profound impact on yield and quality of wheat (Triticum aestivum), the reasonable fertilization management significantly improved yield, quality, and cold resistance of plants. Here, 10 predominant wheat varieties cultivated in the Huang‐Huai‐Hai region were selected to investigate the detrimental influence mechanism of late spring coldness on wheat growth and screen three varieties with a strong resistance to coldness. Additionally, under late spring coldness, the three varieties were applied with varying ratios of base to topdressing nitrogen fertilizer to investigate the consequences on the establishment of population structure and subsequent formation of yield and quality. The results showed that late spring coldness exerted severely detrimental effect on wheat organs development, including the increased occurrence of dead tillers, elevated mortality of young spikes, and significant decrease kernels. However, compared to N1 treatment (a nitrogen fertilizer distribution of 100% base+0% jointing+0% booting), the N2 treatment (50% base+50% jointing+0% booting) exhibited favorable outcomes under late spring coldness, such as the decreased basic seedlings and tillers, increased flag leaf area, and leaf area index, contributing to the higher spike number, grain number, and 1000‐kernel weight. Ultimately, the grain yields of Jinan 17, Huaimai 28, and Yan'nong 5158 reached their maximum values, with a 23.5%, 10.6%, and 24.2% increase, respectively, and the membership function analysis confirmed the most favorable effect of N2 treatment. These findings underscore the appropriately increased ration of topdressing nitrogen fertilizer during late spring coldness as a prerequisite for achieving both high yield and good quality of wheat.
Place type or place function: What matters for place attachment?
Authors: Zahnow Renee 
Published: November 2023

AbstractPlace attachment at neighborhood places can facilitate social ties and community belonging, reduce social isolation and improve physical and mental health outcomes. Research highlights the benefits of place attachment at traditional third places such as cafes and parks but is yet to examine place attachment across a broader suite of highly frequented neighborhood places. Drawing on survey data from a sample of Australian residents (N = 892) with a median age of 55−64 years, this study examines the influence of place form and function on place attachment at everyday places. Findings reveal that places where individuals go to participate in specific and unique activities (e.g., exercise at a gym, prayer at a temple) alongside a defined group of other community members, such as places of worship or gyms, engender stronger place attachment than places of economic consumption, such as large shops and cafes. This is important in its capacity to inform neighborhood planning and policies to reduce risk of social isolation.
Calibration of the Solid‐State Nuclear Magnetic Resonance Search for Axion‐Like Dark Matter
Authors: Winter Andrew J. , Marić Tanja , Balabanova Viktoriya A. , Ádám János , Randall Glenn , Wickenbrock Arne , Jackson Kimball Derek F. , Budker Dmitry , Sushkov Alexander O. 
Published: November 2023

AbstractCalibration of nuclear‐magnetic‐resonance‐based searches for axion‐like dark matter can be performed by free induction decay (FID) measurements. This manu‐ script describes FID experiments on several solid materials, motivated by the Cosmic Axion Spin Precession Experiment (CASPEr) program. Experiments with207Pb nuclear spins in ferroelectrics, lead magnesium niobate‐lead titanate (PbMg1/3Nb2/3O3) (PbTiO3)1/3 (PMN‐PT) and lead zirconium titante PbZr0.52Ti0.48O3 (PZT) are directly relevant to the CASPEr‐electric search for the electric dipole moment interaction of axion‐like dark matter. Experiments with 31P nuclear spins in gadolinium‐doped hydroxypyromorphite Pb4.95Gd0.05(PO4)3OH (HPM:Gd) are used for apparatus calibration. The measurements characterized the nuclear spin ensemble coherence time and the magnetic resonance detection sensitivity for these samples. Calibration is performed using small tip‐angle pulses.
A versatile strategy to construct surface functionalized pH/redox dual stimuli‐responsive nanogels for targeted drug delivery
Authors: Wang Zhao , Shi Jiajian , Gu Mengyao , Zhang Xiaojuan , Sheng Ruilong 
Published: November 2023

AbstractDeveloping facile, green, and efficient synthetic methodology for preparing surface‐functionalized nanogels has attracted tremendous attention in the field of polymer chemistry and biomaterials engineering. Herein, a series of “clickable” P(MAA‐PMA) nanogels with reactive alkyne groups were conveniently prepared by “one‐pot” reflux‐precipitation polymerization (RPP), their particle sizes and zeta potentials are solid content‐dependent. Using P(MAA‐PMA)‐1 nanogels as the model, the physicochemical properties including particle size, surface potential, morphology, solution stability, and pH/redox responsiveness were characterized in detail. Moreover, the pH/redox dual‐responsive drug release feature/kinetics and parameters were analyzed using Korsmeyer–Peppas model and Gallagher–Corrigan model. Then the surface of nanogels was facilely modified with various thiol‐containing functional ligands via thiol‐yne photo click reaction. As targeted drug carriers, doxorubicin (DOX)‐loaded folic acid (FA)‐functionalized nanogels (FA@Nanogels/DOX) demonstrated higher tumor cell proliferation inhibition effect in B16F10 cancer cells than that in CHO‐K1 normal cells, while the non‐FA‐functionalized counterparts (Nanogels/DOX) do not show similar effect. This work provides a versatile “one‐pot RPP‐photo Click functionalization” strategy to construct surface‐functionalized pH/redox dual responsive nanogels for efficient and targeted drug delivery.
Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2‐treated HDF cells of the extracts of Stachys tundjeliensis
Authors: Kurt‐Celep Inci , Zheleva‐Dimitrova Dimitrina , Sinan Kouadio Ibrahime , Uba Abdullahi Ibrahim , Nilofar  , Mahomoodally Mohamad Fawzi , Aumeeruddy Muhammad Zakariyyah , Cakilcioglu Ugur , Dall'Acqua Stefano , Zengin Gokhan 
Published: November 2023

AbstractThe genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio‐pharmaceutical potential and phenolic contents of six different extracts from aerial parts of Stachys tundjeliensis. The obtained results showed that the ethanol extract exhibited the highest antioxidant activity in the antioxidant assays. Meanwhile, the ethanol extract displayed strong inhibitory activity against α‐tyrosinase, the dichloromethane extract exhibited potent inhibition against butyrylcholinesterase, and the n‐hexane extract against α‐amylase. Based on ultra‐high performance liquid chromatography coupled to high‐resolution mass spectrometry analysis, more than 90 secondary metabolites, including hydroxybenzoic acid, hydroxycinnamic acid, and their glycosides, acylquinic acids, phenylethanoid glycosides, and various flavonoids were identified or tentatively annotated in the studied S. tundjeliensis extracts. It was observed that the application of S. tundjeliensis eliminated H2O2‐induced oxidative stress. It was determined that protein levels of phospho‐nuclear factor kappa B (NF‐κB), receptor for advanced glycation endproducts, and activator protein‐1, which are activated in the nucleus, decreased, and the synthesis of matrix metalloproteinase (MMP)‐2 and MMP‐9 also decreased to basal levels. Overall, these findings suggest that S. tundjeliensis contains diverse bioactive compounds for the development of nutraceuticals or functional foods with potent biological properties.
Advancements in scaffold for treating ligament injuries; in vitro evaluation
Authors: Liu Shuang , Al‐Danakh Abdullah , Wang Haowen , Sun Yuan , Wang Lina 
Published: November 2023

AbstractTendon/ligament (T/L) injuries are a worldwide health problem that affects millions of people annually. Due to the characteristics of tendons, the natural rehabilitation of their injuries is a very complex and lengthy process. Surgical treatment of a T/L injury frequently necessitates using autologous or allogeneic grafts or synthetic materials. Nonetheless, these alternatives have limitations in terms of mechanical properties and histocompatibility, and they do not permit the restoration of the original biological function of the tissue, which can negatively impact the patient's quality of life. It is crucial to find biological materials that possess the necessary properties for the successful surgical treatment of tissues and organs. In recent years, the in vitro regeneration of tissues and organs from stem cells has emerged as a promising approach for preparing autologous tissue and organs, and cell culture scaffolds play a critical role in this process. However, the biological traits and serviceability of different materials used for cell culture scaffolds vary significantly, which can impact the properties of the cultured tissues. Therefore, this review aims to analyze the differences in the biological properties and suitability of various materials based on scaffold characteristics such as cell compatibility, degradability, textile technologies, fiber arrangement, pore size, and porosity. This comprehensive analysis provides valuable insights to aid in the selection of appropriate scaffolds for in vitro tissue and organ culture.
Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data
Authors: Zhao Kailong , Li Hongzhou , Zhang Baofeng , Pang Wenwen , Yan Suying , Zhao Xinzhu , Liu Xinyu , Wang Wanting , Han Qiurong , Yao Yao , Chu Tianhao , Feng Zhiqiang , Zhang Qinghuai , Zhang Chunze 
Published: November 2023

AbstractObjectiveExisting studies indicate that advanced colorectal neoplasms exhibit distinct clinical and biological traits based on anatomical sites. However, in China, especially for advanced colorectal neoplasms, there's limited information available on these traits. Our primary objective is to comprehensively study the characteristics of advanced colorectal neoplasm patients in different anatomical sites in China.MethodsWe selected information from the colorectal cancer screening database in Tianjin, China, since 2010 as the study subject. We chose valid information from 3113 patients with comprehensive data and diagnosed advanced colorectal neoplasms (ANs) from a pool of 19,308 individuals to be included in the study. We then conducted further analysis to examine the correlation between these epidemiological data and tumor location.ResultsAmong the 3113 patients, neoplasms in the left side of the colon accounted for the largest proportion, while neoplasms in the right side of the colon had the smallest proportion, followed by rectal neoplasms. The highest proportion of advanced colorectal neoplasms was found among men. In the age group of 39–49 years old, the proportion of left late‐stage advanced colon neoplasms was equal to that of right late‐stage advanced colon neoplasms, while late‐stage advanced rectal neoplasms increased with age. Smoking, drinking, and a history of colon cancer in first‐degree relatives showed statistically significant associations with the location distribution of advanced colorectal neoplasms. A history of appendicitis, appendectomy, cholecystitis, or cholecystectomy did not significantly affect the location distribution of advanced colorectal neoplasms. However, among patients with such histories, there was a statistically significant relationship between advanced colon neoplasms on the right and those on the left and in the rectum. Similar results were observed for BMI.ConclusionOur research findings demonstrate that advanced colorectal neoplasms display unique epidemiological characteristics depending on their anatomical locations, and these distinctions deviate from those observed in Western populations. These insights contribute to a more comprehensive understanding of the topic and offer valuable guidance for future research in China. We advocate for further investigations centered on the anatomical location of colorectal neoplasms to enhance the precision of colorectal cancer (CRC) screening and treatment.
Photochemical Metal‐Hydride Hydrogen Atom Transfer Mediated Radical Hydrofunctionalization of Dienes and Allenes
Authors: Yan Huaipu , Shan Jing‐Ran , Shi Lei 
Published: November 2023

AbstractThe metal‐hydride hydrogen atom transfer (MHAT) method is widely recognized as a powerful technique for functionalizing alkenes. However, its application in the functionalization of industrial feedstock dienes and allenes is relatively rare due to challenges related to chemo‐selectivity. In recent studies, Co‐porphines have been identified as highly efficient catalysts under photoirradiation for MHAT, demonstrating an exceptional level of chemoselectivity for the functionalization of dienes and allenes, while disregarding other simple olefins present. This novel method enables the selective reductive coupling of pyridines with dienes and the allylation of aldehydes by the combination with Ti catalysis. Mechanistic studies and density functional theory (DFT) calculations support the idea that the non‐reversible transfer of hydrogen atoms from cobalt hydride to dienes and allenes, leading to the generation of allyl radicals, is the key step in the catalytic cycle.
Nonlinear Behavior of Methanol Synthesis Compared to CO2 Methanation
Authors: Leipold Johannes , Jung Magnus , Keßler Tobias , Kienle Achim 
Published: November 2023

AbstractThe nonlinear behavior of CO2 methanation over a Ni‐catalyst is compared to methanol synthesis over a standard Cu/ZnO‐catalyst in a continuous stirred tank reactor (CSTR). Both reactions have received a lot of attention these days for chemical energy storage. Both reactions are exothermic but behave in a different way. CO2 methanation is known to be strongly exothermic, giving rise to multiple steady states. This behavior is induced by the self‐acceleration of the methanation reaction because the heat production of the chemical reaction increases with rising temperature. It is shown that methanol synthesis behaves fundamentally different under the operating conditions usually employed in practice. It is less exothermic but, even more important, the overall heat production of the methanol reaction system decreases with increasing temperature, giving rise to a unique and stable steady state. This insight is obtained with an extension of the classical graphical analysis with heat production and heat removal curves.
Production and Characterization of Biodiesel from Castor Seed Oil Using Cocoa Pod Ash as Catalyst
Authors: Olatayo Olahanmi A. , Sunday Ogunniyi D. , Olaluwoye Oladimeji S. 
Published: November 2023

AbstractA major problem retarding the commercialization of biodiesel is the derivation of catalysts and feedstocks from high‐cost materials. Hence, the following proposal is being put forward to mitigate this challenge: Extract and characterize castor oil, synthesize and characterize cocoa pod ash as the base catalyst, and apply the base catalyst for biodiesel production. Cocoa pods were heated at 600 °C for 35 min in a muffle furnace and the product sieved to obtain ash with uniform size distribution. The yield of castor oil extracted was 42 %, and the synthesized catalyst was capable of transesterifying the extracted oil. Castor oil was converted to biodiesel with cocoa pod ash as catalyst. A biodiesel yield of 88 % was obtained. The catalyst was characterized by various methods to confirm the presence of active sites. The physicochemical properties of the biodiesel product are consistent with literature values.
Microelectrode Arrays, Electrocatalysis, and the Need for Proper Characterization
Authors: Huang Albert , Krueger Ruby , Moeller Kevin D. 
Published: November 2023

AbstractIndirect electrochemical methods are a powerful tool for synthetic chemistry because they allow for the optimization of chemical selectivity in a reaction while maintaining the advantages of electrochemistry in terms of sustainability. Recently, we have found that such methods provide a handle for not only the synthesis of complex molecules, but also the construction of complex, addressable molecular surfaces. In this effort, the indirect electrochemical methods enable the placement or synthesis of molecules by any electrode or set of electrodes in a microelectrode array. The success of these surface‐based reactions are typically evaluated with the use of fluorescence labelling studies. However, these fluorescence‐based evaluations can be misleading. While they are excellent for determining that a reaction has occurred in a site‐selective fashion on an array, they do not provide information on whether that reaction is the one desired or how well it worked. We describe here how the use of a “safety‐catch” linker strategy allows for a more accurate assessment of reaction quality on an array, and then use that capability to illustrate how the use of transition metal mediated cross‐coupling reactions on an array prevent unwanted background reactions that can occur on a polymer‐coated electrode surface. The method enables a unique level of quality control for array‐based transformations.
Immunohistochemical characteristics and potential therapeutic regimens of hepatoid adenocarcinoma of the stomach: a study of 139 cases
Authors: Yang Xuesong , Wu Yan , Wang Anqiang , Ma Xiuli , Zhou Kai , Ji Ke , Ji Xin , Zhang Ji , Wu Xiaojiang , Li ZhongWu , Bu Zhaode 
Published: November 2023

AbstractHepatoid adenocarcinoma of stomach (HAS) is a special subtype of gastric cancer with poor prognosis. Immunohistochemical analysis could provide important clues for the treatment of HAS. A total of 159 patients were diagnosed as HAS and 139 were enrolled in this study. Statistical differences were determined using relative test methods and survival analyses were performed by the Kaplan–Meier method to find survival differences. All tumors in this study were negative for Epstein–Barr virus‐encoded small RNAs (EBERs) and almost all showed no loss of mismatch repair (MMR) proteins and were positive for alpha fetoprotein (AFP or spalt like transcription factor 4 (SALL4). About half of the tumors had a positive programmed death‐ligand 1 combined positive score (CPS) and 17.3% were positive for human epidermal growth factor receptor 2 (HER2). In addition, there was a relatively high proportion of cmet expression. We also found that HAS patients with recurrent disease treated by emerging therapy had a better survival than those treated with traditional chemotherapy (p = 0.002, median recurrence‐to‐death survival: 23 months versus 6 months); HAS patients who received anti‐HER2 therapy or harbored MMR deficiency had favorable prognosis. Overall, high proportions of MMR protein proficiency, positivity for AFP or SALL4, overexpression of HER2, CPS and cmet, as well as negative EBER findings, are distinctive characteristics of HAS patients. While negative EBER and MMR proficiency indicate molecular features of HAS, positivity for AFP or SALL4 could aid in the diagnosis of HAS. In addition, HAS patients could benefit from anti‐HER2 therapy, immunotherapy, and anti‐angiogenesis therapy.