bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds
Authors: Changsan Narumon , Srichana Teerapol , Atipairin Apichart , Sawatdee Somchai 
Published: December 2023

Objective: To study the clinical efficacy of a polymeric spray film containing Centella asiatica extract to heal acute wounds. Method: A polymeric spray film solution for wound healing was formulated using Centella asiatica extract, which contained triterpenes, including asiatic acid, madecassic acid, asiaticoside and madecassoside. The stability and physicochemical properties of the formulation were evaluated, and a multicentre, randomised, controlled trial was conducted to assess its clinical wound-healing efficacy. The Pressure Ulcer Scale for Healing (PUSH Tool) score was used to evaluate wound healing on days 0, 3, 5 and 7. Results: The cohort consisted of 60 volunteers with clean-contaminated wounds (class 1), randomly assigned to the Control (n=30) and Testing (n=30) groups. The spray product contained asiatic acid, madecassic acid, asiaticoside and madecassoside at 0.20±0.02mg/ml, 0.16±0.01mg/ml, 0.32±0.03mg/ml and 0.10±0.00mg/ml, respectively. The pH value was 5.5±0.01, and the viscosity was 33±4cP. The product was stable for six months when stored at 30±2°C and at 40±2°C, in 75±5% relative humidity. The tested product significantly reduced the total PUSH and exudate scores, indicating that the polymeric spray film solution containing Centella asiatica improved wound healing. The average healing recovery times for the Testing and Control groups were 4.6±1.1 days and 4.87±1.0 days, respectively. Conclusion: In this study, Centella asiatica extract-containing polymeric spray film solution was beneficial as an acute wound medication, which could shorten healing time with no adverse effects.
Demonstration of real-time jitter-buffered architecture that collects network information for deterministic optical communication
Authors: Koyasako Yushi , Suzuki Takahiro , Hatano Tomoya , Shimada Tatsuya , Yoshida Tomoaki 
Published: December 2023

Demand has been increasing for accurate remote motion control of IoT devices, but jitter can negatively impact control performance. Jitter buffering has been studied as a solution, but it is necessary to obtain delay values in real-time. In this study, we propose an architecture that collects end-to-end delay values in real-time, implements jitter buffering based on the obtained values, and implements more detailed delay compensation control based on fixed delay values. This allows network conditions, which are normally out of the user’s control, to be used to optimize the user’s IoT device control application. We construct a basic motor-based experimental system around an FPGA and verify the effectiveness of the proposed method. Experiments show that the proposed method performs the jitter buffering even under a high-network-load environment and achieves successful motor control within 1.5 s by handling delay changes.
A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection
Authors: Naouar Ikbel , Kammoun Rebai Wafa , Ben Salah Afif , Bouguerra Hind , Toumi Amine , Hamida Nabil Belhadj , Louzir Hechmi , Meddeb-Garnaoui Amel 
Published: December 2023

Background
This study aimed to define immunological markers of exposure to L. major parasites and identify correlates of protection against infection.

Methods
We analyzed a cohort of 790 individuals at risk of developing ZCL living in endemic areas with varying L. major infection prevalence. One area had a high infection prevalence indicated by high proportions of leishmanin skin test (LST) positive subjects, while the other areas were recent foci with lower infection prevalence. Blood samples were collected before the transmission season to measure Interferon gamma (IFN-γ), Interleukin 10 (IL-10), and Granzyme B (GrB) levels in response to parasite stimulation in peripheral blood mononuclear cells.
A one-year follow-up period involved active detection of new ZCL cases to estimate disease incidence after a transmission season and identify immune correlates of protection.

Results
The study population showed heterogeneity in parasite contact, evident from specific scars and/or positive LST results, significantly higher in the old focus compared to recent foci. IFN-γ and GrB were markers of parasite exposure and reliable indicators of immunity to L. major. Positive correlations were observed between IFN-γ/IL-10 and GrB/IL-10 ratios and LST results.
Unexpectedly, only 29 new ZCL cases (4%) appeared after a transmission season, with 27 cases reported in recent foci and 2 in the oldest focus. Our findings indicate that individuals in L. major endemic areas are likely to develop ZCL regardless of their LST status.
We showed that high pre-transmission season levels of IFN-γ and GrB produced by PBMC, along with a high IFN-γ/IL-10 ratio, were associated with protection.

Conclusion
This study on a large cohort at risk of ZCL confirmed IFN-γ and GrB as protective factors against the disease. A high IFN-γ/IL-10 ratio, but not GrB/IL-10 ratio was associated with resistance. These results are valuable for developing and evaluating of a vaccine against human leishmaniasis.
Effects of high-intensity functional training on physical fitness and sport-specific performance among the athletes: A systematic review with meta-analysis
Authors: Wang Xinzhi , Soh Kim Geok , Samsudin Shamsulariffin , Deng Nuannuan , Liu Xutao , Zhao Yue , Akbar Saddam 
Published: December 2023

Objective
This study aims to meta-analyze the impact of high-intensity functional training on athletes’ physical fitness and sport-specific performance.

Methods
A systematic search was conducted in five well-known academic databases (PubMed, Scopus, Web of Science, EBSCOhost, and the Cochrane Library) up to July 1, 2023. The literature screening criteria included: (1) studies involving healthy athletes, (2) a HIFT program, (3) an assessment of outcomes related to athletes’ physical fitness or sport-specific performance, and (4) the inclusion of randomized controlled trials. The Physical Therapy Evidence Database (PEDro) scale was used to evaluate the quality of studies included in the meta-analysis.

Results
13 medium- and high-quality studies met the inclusion criteria for the systematic review, involving 478 athletes aged between 10 and 24.5 years. The training showed a small to large effect size (ES = 0.414–3.351; all p < 0.05) in improving upper and lower body muscle strength, power, flexibility, and sport-specific performance.

Conclusion
High-intensity functional training effectively improves athletes’ muscle strength, power, flexibility, and sport-specific performance but has no significant impact on endurance and agility. Future research is needed to explore the impact of high-intensity functional training on athletes’ speed, balance, and technical and tactical performance parameters.
Stereocomplex PLLA–PBAT copolymer and its composites with multi-walled carbon nanotubes for electrostatic dissipative application
Authors: Veang-in Onpreeya , Srithep Yottha , Morris John , Aussawasathien Darunee , Worajittiphon Patnarin 
Published: December 2023

Abstract
Because of its low thermal stability and brittleness, both the drawbacks of poly(l-lactide) (PLLA) were solved by forming stereocomplex (ST) and its copolymer with poly(butylene adipate-co-terephthalate) (PLLA–PBAT). In this study, we synthesized PLLA and PLLA–PBAT copolymer by ring-opening polymerization. Both polymers were blended with poly(d-lactide) to form ST crystals. Multi-walled carbon nanotubes (MWCNTs) were added into the polymer matrix at 5 phr by the solvent casting method. The surface resistance of the composite was ≅106 Ω, which is appropriate for electrostatic dissipative purposes. The copolymer and its ST crystallites were confirmed by the peaks in infrared spectra at 922 and 908 cm−1, respectively. The PLLA–PBAT copolymer had 60% lower tensile strength than PLLA and its stereocomplex, but 10% higher elongation at break. The elongation at break of the PLLA–PBAT copolymer/MWCNT composite decreased by 17% while its thermal stability slightly increased when compared to the unfilled copolymer. The melting temperature for both ST PLLA–PBAT copolymers, with and without MWCNTs, was around 225°C, which is 50°C higher than that of the homocrystals. Moreover, the glass transition temperature and crystallinity of the ST PLLA–PBAT copolymer also increased by adding MWCNTs.
Rainfall-induced transportation embankment failure: A review
Authors: Linrong Xu , Usman Aliyu Bamaiyi , Bello Al-Amin Danladi , Yongwei Li 
Published: December 2023

Abstract
Rainfall is one of the leading causes of transportation embankment failure. Similarly, the fill material properties and the loading conditions of the embankment serve as principals for assessing the mechanisms of potential failures that are derived from rainfall-related events. These events affect the hydro-mechanical behaviors of embankment fills and cast doubt on the construction and service life of most transportation-infrastructure. This article presents a review, of existing available records to critically examine rainfall-induced transportation embankment failures, causes, mechanisms, existing measures, and prevention techniques. Consequently, a review of the susceptibility assessment of infrastructures due to rainfall-induced failures, particularly in China, and embankment characteristics and their effects on the duration, magnitude, and safety of the infrastructures was carried out. The study was able to classify rainfall conditions as they influence embankment stability. We suggest the development of local and global rainfall-embankment fill material relationships that will give unique information on how rainfall-events change the behavior of fill material and to what extent they trigger failures. A summary of some of the active processes leading to transportation embankment failures is presented. Finally, we concluded by identifying future and prospective rainfall-induced transportation embankment failures that will enhance monitoring and mitigation of instability in embankments.
The 𝔪-WG° inverse in the Minkowski space
Authors: Liu Xiaoji , Zhang Kaiyue , Jin Hongwei 
Published: December 2023

Abstract
In this article, we study the

m

{\mathfrak{m}}

-WG

∘

{}^{\circ }

inverse which presents a generalization of the

m

{\mathfrak{m}}

-WG inverse in the Minkowski space. We first show the existence and the uniqueness of the generalized inverse. Then, we discuss several properties and characterizations of the

m

{\mathfrak{m}}

-WG

∘

{}^{\circ }

inverse by using the core-EP decomposition. Applying the generalized inverse, we obtain the solutions of some matrix equations in Minkowski space.
User verification of Abbott Alinity HQ hematology analyzer
Authors: Bayraktar Nilufer , Topcu Deniz Ilhan 
Published: December 2023

Abstract

Objectives
This study aims to evaluate the performance characteristics of the Alinity HQ hematology analyzer in a routine laboratory setting.

Methods
In the study, precision (short-term and long-term precision), accuracy (method comparison with Abbott Cell Dyn Ruby and estimation of bias), confirmation of a background (Limit of Blank, LoB), and carry-over were used to evaluate the performance of Alinity HQ as recommended by ICSH, CLSI guidelines EP15-A3, EP09, EP17A2, and H26-A2. Acceptance criteria were based on manufacturer technical specifications and the EFLM Biological Variation Database.

Results
According to the short-term precision results, except for mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC), all measurements exhibited coefficient variations (CV) lower than their verification limits. Basophil, eosinophil, and monocyte counts, as well as mean corpuscular hemoglobin (MCH), MCHC, and red cell distribution width standard deviation (RDW-SD), did not meet the allowable imprecision criteria for the long-term precision study. The estimated bias for all analytes was within verification limits. However, the method comparison study showed concentration-dependent variations for MCHC, MCH, and mean platelet volume (MPV) parameters. Furthermore, the correlation of parameters between Alinity HQ and Cell Dyn Ruby ranged from 0.46 to 1.00. The LoB and carry-over studies demonstrated satisfactory performance for the Alinity HQ analyzer.

Conclusions
Although some parameters had higher CVs than expected and concentration-dependent bias, the overall analytical performance of Alinity HQ was found to be satisfactory. Alinity HQ is an accurate, highly precise analyzer with good analytical performance, suitable for high-volume laboratories.
Afetividade e ambiente de trabalho dos enfermeiros: estudo transversal
Authors: Ferreira Maria Margarida , Vidal Diogo Guedes , Teixeira Joana Margarida , Silva Mafalda Sofia , Parola Vitor Sérgio 
Published: December 2023

Objetivo: identificar as relações de afetividade estabelecidas no ambiente de trabalho dos enfermeiros. Método: estudo quantitativo, do tipo analítico, transversal composto por 72 Enfermeiros a trabalharem nos serviços de internamento e de urgência. Foram aplicadas as escalas do “Bem-estar Psicológico”, “Estilo de Vida Fantástico” e “Ambiente de Trabalho da Prática de Enfermagem”. Resultados: a amostra é constituída maioritariamente por enfermeiras (80,6%), solteiras (61,1%), 94,4% quase sempre tem alguém com quem conversar sobre assuntos importantes e 88,9% relata quase sempre dar e receber carinho. Falta de afeto impacta negativamente na perceção da colaboração entre médicos e enfermeiros, atualização dos planos de cuidados de enfermagem e relevância do diagnóstico de enfermagem. Conclusão: verificou-se um desequilíbrio nas dimensões afetividade e relações interpessoais, as quais influenciam negativamente a qualidade no ambiente de trabalho.
Parathyroid adenoma apoplexy mimicking a thyroid bleeding cyst: a seemingly innocent condition that can be life-threatening
Authors: Van de Kerkhof Jasmine , Bijnens Jacqueline , De Geeter Frank , Dick Catherine , De Paepe Pascale , Van den Bruel Annick 
Published: December 2023

Summary
Primary hyperparathyroidism most commonly presents with hypercalcaemia. Rarely, parathyroid apoplexy or haemorrhage mimicking a thyroid bleeding cyst is the first presentation of a parathyroid adenoma. A woman presented with a sudden-onset painful ‘goitre’. Ultrasound showed a cystic nodule located posterior to rather than in the right thyroid lobe, suggesting parathyroid adenoma bleeding. Biochemistry showed mild primary hyperparathyroidism. 99mTc-pertechnetate/sestamibi showed no uptake in the nodule, which was interpreted as a cold thyroid nodule. 18F-fluorocholine PET/CT showed uptake in the nodule, suggestive of a parathyroid adenoma. Persistent mild primary hyperparathyroidism complicated by nephrolithiasis and osteopenia favoured parathyroidectomy over a wait-and-see approach. The patient was referred for parathyroidectomy along with right thyroid lobectomy. Pathology showed an adenoma, with an eccentrically located cystic structure filled with red blood cells surrounded by a thickened fibrous capsule. In conclusion, cervical pain/haemorrhage with hypercalcaemia points to the diagnosis of parathyroid apoplexy, mimicking a thyroid bleeding cyst. Workup with ultrasound and, if available, 18F-choline PET/CT allows for timely surgery, minimizing the risk of recurrent and severe bleeding.

Learning points

A bleeding cyst may be located posterior to rather than in the thyroid, suggesting a parathyroid haemorrhage.

Neck pain and/or haemorrhage along with primary hyperparathyroidism point to parathyroid apoplexy.

A two-step presentation has been described, with a first phase of local symptoms to be followed by visible and possibly life-threatening compressing bleeding.

Therefore, an expedited workup is needed, allowing for timely surgery.
Spermatogonial depletion and a spermatogenesis defect in the Dp(16)1Yey mouse model of Down syndrome
Authors: Dard Rodolphe , Tutunaru Anastasia , Bouassida Malek , Balde Camara Aissatu , Parizot Estelle , Kassis Nadim , Fortemps Joanne , Cierniewski Céline , Racine Chrystele , Di-Clemente Nathalie , Vialard François , Janel Nathalie 
Published: December 2023

In brief
Little is known about the mechanism responsible for male infertility in Down syndrome. Duplication of Mmu16 chromosome (an orthologue of Hsa21, bearing Dyrk1A) in Dp(16)1Yey mice is responsible for impaired spermatogenesis through spermatogonial depletion and hypogonadotropic hypogonadism.

Abstract
Down syndrome (DS), or trisomy 21, is the most common chromosomal disorder in humans. Men with DS are infertile. The DYRK1A gene on Hsa21 is involved in several features of DS. Overexpression of the homolog dyrk1A disrupts primordial germ cell migration in zebrafish, and overexpression of Dyrk1A impairs gonadotropic axis function and the early stages of spermatogenesis in the mouse. Other genes on Hsa21 might be involved in the pathogenesis of infertility in DS. We investigated the Dp(16)1Yey mouse model of DS, which features segmental duplication of chromosome Mmu16 (orthologous to a large part of Hsa21 and carrying Dyrk1A and 112 other genes). Using an immunohistochemical assay for the spermatogonial marker STRA8, we observed spermatogonial depletion in the Dp(16)1Yey mouse. This was correlated with low mRNA expression of GFRα1 (a marker of the self-renewal stem cell pool) in an RT-qPCR assay and low protein expression of PLZF (a marker of differentiating stem cells) in a slot-blot assay. Spermatogenesis was present but impaired, with a low sperm count, low protamine-1 expression, a low testis weight, and a low seminiferous tubule diameter. Low circulating luteinizing hormone and follicle-stimulating hormone levels and an elevated testis anti-Müllerian hormone level (as measured in ELISAs) revealed the presence of hypogonadotropic hypogonadism. The Dp(16)1Yey mouse model of DS recapitulates observations made in zebrafish and mice overexpressing DYRK1A homologs. The presence of an excess of Mmu16 material perturbs spermatogenesis and the gonadotropic axis. More generally, DYRK1A’s role in human infertility (outside DS) remains to be characterized.
Designing an Algorithm for Automated Analysis of Completed Tasks in a Mobile Learning System
Authors: Sultanov B. , Zufarov Z.M. , Xudayberdiyev S.A. , Tillashayxova M.A. , Samigova G.A. , Savochkin M.P. 
Published: December 2023

Purpose: this abstract discusses an urgent problem in the modern education system associated with the need to adapt to rapid changes in social spheres and the economy. The main purpose of the study is to develop an adaptive mobile learning environment for higher education institutions, with an emphasis on the use of electronic (mobile) learning and information and analytical support for the educational process.
Methods: to achieve this goal, an analysis of existing research and publications in the field of educational technologies and the effectiveness of e-learning was carried out. The objectives of adaptive mobile learning technologies are formulated, including the creation of a virtual learning environment and the development of effective methods of text processing in distance learning.
Results: in the course of the study, an algorithm for an adaptive mobile learning environment system based on an autonomous analysis of completed tasks using neural networks was proposed. To ensure the reliability of the system, it is proposed to implement a task analysis service as a background process. A scheme for transferring information from mobile applications to a background analytical service has been developed, taking into account the use of the RabbitMQ queue for organizing communication between services. An algorithm for detailed analysis of the text of completed assignments of students has also been developed.
Conclusions: the study highlights the need to adapt educational systems to modern challenges and the possibility of using adaptive mobile learning technologies. The developed algorithm and system provide an effective analysis of assignments and text responses of students, which makes them relevant in the context of modern information technologies and education.
Человек и бог: формы взаимодействия в образах фразеологизмов
Authors: Мокиенко Валерий , Никитина Татьяна 
Published: December 2023

В статье на материале фразеологизмов русского и других славянских языков с привлечением вен-герских фразеологических параллелей рассматривается образная составляющая концепта «Бог». Для анализа отобраны фразеологизмы, образы которых отражают взаимодействие Бога и человека. Цель статьи – показать, как в ассоциативных механизмах фраземообразования и ситуациях, отра-жаемых прототипами идиом и пословиц, реализуются общехристианские представления о миро-устройстве и национально специфические интерпретации взаимодействия человека и Бога.Анализируются обороты, восходящие к текстам Библии и представляющие сцены земной жизни Христа, его контакты с последователями и преследователями. В народных фразеологизмах, которые также стали объектом сопоставительного анализа, метафорически переосмысляются ситуации вза-имодействия Бога и простого человека. Клишированные обращения человека к Богу как еще один вид взаимодействия человека и Бога, содержат просьбы о семейном благополучии, здоровье, удаче.Выявлены общие идеологемы, передаваемые конфессионно маркированными фразеологизмами и паремиями славянских языков и венгерского языка. Этот материал свидетельствует о том, что Бог в народных представлениях – заботливый покровитель, помощник человека. Бог определяет судьбу человека, сроки его жизни, отдельные поступки. Бог требует соблюдения определенных мораль-но-этических норм и сурово наказывает за отступление от них.Анализ нашего материала позволяет сделать предварительные заключения о фраземообразова-тельной активности отдельных библейских мотивов в разных лингвокультурах: страдания Христа, отречение его учеников, карающая сила Бога шире представлены в образах западнославянских фра-зеологизмов. Русские фразеологизмы с компонентом «Бог» чаще строятся на ассоциациях с благодатью, фразеологически представленное общение с Богом зачастую можно охарактеризовать как неформальное, на Бога чаще перекладывается ответственность за опрометчивые или неблаговид-ные поступки. Симбиоз языческих и христианских представлений о мироустройстве особенно ярко иллюстрируют русские и венгерские фразеологические обороты, в которых упоминаются русский бог, венгерский бог. На русском и венгерском материале показаны также механизмы десакрализа-ции слова Бог и его использования в угрозах-обсценизмах.Особое внимание уделяется анализу народно-этимологических и профессиональных версий про-исхождения конфессионально детерминированных фразеологизмов. Подчеркивается, что резуль-таты проведенного исследования могут быть полезны при составлении лингвокультурологических словарей и словарей библеизмов.