bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinerja Badan Pendapatan Daerah Kabupaten Badung Pasca Restrukturisasi Organisasi Periode Tahun 2017
Authors: Rania Ni Putu Nari , Prabawati Ni Putu Anik , Wismayanti Kadek Wiwin Dwi 
Published: November 2023

The purpose of this study was to determine how the performance of the Badung Regency Regional Revenue Agency after the organizational restructuring carried out in 2017. This research uses a qualitative research method with a descriptive approach that collects data through observation, interviews, and documentation methods. This study uses the performance theory by Iwan Novarian (2020) with 4 (four) types of indicators, namely input, process, output, and outcome. Using these four performance indicators, the results explain that all indicators have been running, but there are still some indicators that are not fully optimized. This shortcoming requires strengthening for each indicator.

Abstrak
Tujuan penelitian ini untuk mengetahui bagaimana kinerja Badan Pendapatan Daerah Kabupaten Badung pasca restrukturisasi organisasi yang dilaksanakan pada tahun 2017. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif yang pengumpulan data melalui metode observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan teori kinerja oleh Iwan Novarian (2020) dengan empat (4) jenis indikator, yakni indikator masukan, indikator proses, indikator keluaran, dan indikator hasil. Dengan menggunakan keempat indikator kinerja tersebut, didapatkan hasil yang menjelaskan bahwa seluruh indikator telah berjalan, namun masih terdapat beberapa indikator yang belum sepenuhnya optimal. Adanya kekurangan tersebut memerlukan penguatan bagi setiap indikator.
Kata Kunci: Restrukturisasi Organisasi, Kinerja, Badan Pendapatan Daerah, dan Pendapatan Asli Daerah (PAD).
Comparative study of the efficacy of intra-arterial and intravenous transplantation of human induced pluripotent stem cells-derived neural progenitor cells in experimental stroke
Authors: Cherkashova Elvira , Namestnikova Daria , Leonov Georgiy , Gubskiy Ilya , Sukhinich Kirill , Melnikov Pavel , Chekhonin Vladimir , Yarygin Konstantin , Goldshtein Dmitry , Salikhova Diana 
Published: November 2023

Background
Cell therapy using neural progenitor cells (NPCs) is a promising approach for ischemic stroke treatment according to the results of multiple preclinical studies in animal stroke models. In the vast majority of conducted animal studies, the therapeutic efficacy of NPCs was estimated after intracerebral transplantation, while the information of the effectiveness of systemic administration is limited. Nowadays, several clinical trials aimed to estimate the safety and efficacy of NPCs transplantation in stroke patients were also conducted. In these studies, NPCs were transplanted intracerebrally in the subacute/chronic phase of stroke. The results of clinical trials confirmed the safety of the approach, however, the degree of functional improvement (the primary efficacy endpoint) was not sufficient in the majority of the studies. Therefore, more studies are needed in order to investigate the optimal transplantation parameters, especially the timing of cell transplantation after the stroke onset. This study aimed to evaluate the therapeutic effects of intra-arterial (IA) and intravenous (IV) administration of NPCs derived from induced pluripotent stem cells (iNPCs) in the acute phase of experimental stroke in rats. Induced pluripotent stem cells were chosen as the source of NPCs as this technology is perspective, has no ethical concerns and provides the access to personalized medicine.

Methods
Human iNPCs were transplanted IA or IV into male Wistar rats 24 h after the middle cerebral artery occlusion stroke modeling. Therapeutic efficacy was monitored for 14 days and evaluated in comparison with the cell transplantation-free control group. Additionally, cell distribution in the brain was assessed.

Results
The obtained results show that both routes of systemic transplantation (IV and IA) significantly reduced the mortality and improved the neurological deficit of experimental animals compared to the control group. At the same time, according to the MRI data, only IA administration led to faster and prominent reduction of the stroke volume. After IA administration, iNPCs transiently trapped in the brain and were not detected on day 7 after the transplantation. In case of IV injection, transplanted cells were not visualized in the brain. The obtained data demonstrated that the systemic transplantation of human iNPCs in the acute phase of ischemic stroke can be a promising therapeutic strategy.
Investigating altered brain functional hubs and causal connectivity in coronary artery disease with cognitive impairment
Authors: Qin Rui , Li Tong , Li Cuicui , Li Lin , Wang Ximing , Wang Li 
Published: November 2023

Background
Coronary artery disease (CAD) and cognitive impairment (CI) have become significant global disease and medical burdens. There have been several reports documenting the alterations in regional brain function and their correlation with CI in CAD patients. However, there is limited research on the changes in brain network connectivity in CAD patients. To investigate the resting-state connectivity and further understand the effective connectivity strength and directionality in patients with CAD, we utilized degree centrality (DC) and spectral dynamic causal modeling (spDCM) to detect functional hubs in the whole brain network, followed by an analysis of directional connections. Using the aforementioned approaches, it is possible to investigate the hub regions and aberrant connections underlying the altered brain function in CAD patients, providing neuroimaging evidence for the cognitive decline in patients with coronary artery disease.

Materials and Methods
This study was prospectively conducted involving 24 patients diagnosed with CAD and 24 healthy controls (HC) who were matched in terms of age, gender, and education. Functional MRI (fMRI) scans were utilized to investigate brain activity in these individuals. Neuropsychological examinations were performed on all participants. DC analysis and spDCM were employed to investigate abnormal brain networks in patients with CAD. Additionally, the association between effective connectivity strength and cognitive function in patients with CAD was examined based on the aforementioned results.

Results
By assessing cognitive functions, we discovered that patients with CAD exhibited notably lower cognitive function compared to the HC group. By utilizing DC analysis and spDCM, we observed significant reductions in DC values within the left parahippocampal cortex (PHC) and the left medial temporal gyrus (MTG) in CAD patients when compared to the control group. In terms of effective connectivity, we observed the absence of positive connectivity between the right superior frontal gyrus (SFG) and PHC in CAD patients. Moreover, there was an increase in negative connectivity from PHC and MTG to SFG, along with a decrease in the strength of positive connectivity between PHC and MTG. Furthermore, we identified a noteworthy positive correlation (r = 0.491, p = 0.015) between the strength of connectivity between the PHC and the MTG and cognitive function in CAD patients.

Conclusions
These research findings suggest that alterations in the connectivity of the brain networks involving SFG, PHC, and MTG in CAD patients may mediate changes in cognitive function.
The Mediating Role of Investment: Analyzing the Causal Impact of Inflation on Economic Growth and the Influence of Capital Expenditure
Authors: Ma`rifatturrohanah  , Najmudin Najmudin , Widiastuti Ekaningtyas 
Published: November 2023

Aims: This paper aims to test the impact of inflation and capital expenditure on regional growth of economy employing the investment as a mediating variable in Central Java from 2017 to 2022.
Study Design: The population of this research is 35 districts or cities in Central Java Province for 2017–2022 period. This paper uses secondary data or quantitative approach taken from the Statistics Central Bureau.
Methodology: The method used to collect data is purposive sampling with data analysis using the Structural Equation Modeling model. Data is processed through the Smart PLS 4.0 program applying Structural Model analysis (Inner Model) as an analysis technique of data.
Results: The findings of this paper suggest that: (1) Inflation had no effect significantly on growth of economy. (2) Investment level had an effect positively on growth of economy. (3) Inflation had an effect negatively on the investment. (4) Investment had an effect significantly in mediating the causality of the inflation to growth of economy. (5) The capital expenditure had an effect positively on growth of economy.
Composition of Tuna Catch Hand Line at the Fish Landing Base (FLB) Lonrae, Bone Regency, South Sulawesi Province, Indonesia
Authors: Danial  , Baroqi A. Riza , Wildan  , Timur Putra Satria , Syahrul  
Published: November 2023

Fish landed at fishing ports generally come from various species, fisheries management has developed into a decentralized system. Tuna is one type of economically important fish in the world and is the third largest fishery commodity in Indonesia. The aim of this research is to determine the size composition of catches and analyze the relationship between length and weight of hand line tuna catches. Data collection techniques were carried out by observing and measuring as well as interviews with crew members of hand-line fishing boats who landed their catches at the Lonrae Fish Landing Base (FLB). Descriptive data is presented in the form of tables and graphs. The statistical analysis used is a simple regression between two variables, namely the length and weight of the fish. Next, to get the regression coefficients, the data is processed using the graphical method provided in MS Excel software. The catch of hand line tuna boats landed at FLB Lonrae, consists of three species of tuna, namely: yellowfin tuna (Thunnus albacares), skipjack tuna (Katsuwonus pelamis) and bigeye tuna (Thunnus obesus). The length-weight relationship of 876 Yellowfin tuna fish obtained a value of b=3.08, the length-weight relationship of 467 Skipjack Tuna fish obtained a b value of 2.71 and the length-weight relationship of 430 Bigeye tuna fish obtained a value of b=2.97 shows positive allometric growth where weight growth is faster than length growth. The tuna species composition observed at PPI Lonrae Bone Regency consisted of 3 species, namely Yellowfin Tuna, Bigeye Tuna and Skipjack. Composition of tuna species YFT=29.2% BET=11.8% and SKJ =58.97%.
Assessing the Performance of Latest Greengram Varieties under Improved production Packages in Thiruppur, Tamil Nadu, India
Authors: Kathiravan M.  , Vanitha C.  , Ayyadurai P.  , Krishnaveni A.  , Yuvaraj M.  
Published: November 2023

On Farm Testing (OFT) in Mungbean Yellow Mosaic Virus (MYMV) resistant and high yielding greengram varieties was conducted by Krishi Vigyan Kendra, Tamil Nadu Agricultural University, Tirupur in farmers field during kharif 2020. Totally 15 farmers each with one acre were selected in three villages of Pongalur Block in Tirupur district of Tamil Nadu. Critical input viz., seeds of greengram varieties CO 8 and DGG 1 were distributed to the farmers and the varietal performance were assessed along with the existing variety under cultivation VBN 2. The plant physiological parameters viz., plant height, number of nodules / plant and yield attributing parameters such as number of pods / plants, number of branches/plant, Mung bean Yellow Mosaic Virus (MYMV) disease incidence (%), yield (q ha-1) and B:C ratio were recorded. The results revealed that, among the three varieties, Greengram CO 8 was recorded more number of pods (42) and minimum incidence of Mungbean Yellow Mosaic Virus (MYMV) disease incidence of 3.2 per cent resulting in the highest yield of 9.5 q ha-1 followed by DDG 1 with 34 pods/plant, MYMV disease incidence of 7.3 per cent and yield of 8.4 q ha-1 compared to the existing variety VBN 2, which recorded the lowest number of pods (31 Nos.), yield (7.6 q ha-1) with the highest MYMV disease incidence (12.5%). The highest B:C ratio was recorded in greengram variety CO 8 (2.92) which was followed by DDG 1 (2.58). It was concluded that, farmers of Tirupur district in Tamil Nadu were satisfied with cultivation of greengram CO 8 variety due to the lowest disease incidence, higher yield and Benefit Cost Ratio.
Millet Starch – A Potential Functional Ingredient
Authors: Prasad Priyanka , Sahu Jatindra K. , Srivastava Ashutosh K. 
Published: November 2023

Millets are primitive grains that were majorly cultivated in Indian subcontinent from ancient times. These are small seeded categorized as major and minor millets. Millets are resilient to adverse effects of climate change. They are regarded as "nutri-cereal" due to their high nutritional value compared to rice, wheat, and corn. Starch is the major nutritional constituent of millets with average content ranging from 55% to 61% in different millets. The application of millets depends on the physicochemical, structural, and functional properties of their starch. Millet starch is majorly isolated by wet milling methods, however, studies have shown the effect of dry milling on structural and functional properties of millet starches. Moreover, non-thermal methods have also been employed to enhance the functionality of millet starches. Studies have also demonstrated the functionality of millets in improvement of human metabolic heath and reduction of life-style related diseases. Modified millet starches are also utilised in food and non-food industries.
Biomimetic Targeting Nanoplatform for Atherosclerosis Theranostics Via Photoacoustic Diagnosis and “Hand‐In‐Hand” Immunoregulation
Authors: Ma Boxuan , Chen Zhezhe , Xu Hong , Sun Shuo , Huang Chengchen , Li Gaocan , Zhang Wenbin , Shang Min , Wang Yunbing , Fu Guosheng 
Published: November 2023

AbstractAtherosclerosis can cause severe cardiovascular disease, which is usually diagnosed in late stages with life‐threatening complications. The lack of obvious symptoms limits its early diagnosis and timely treatment. In this work, a theranostic nanoplatform PGA@PMP is constructed for targeting photoacoustic diagnosis and a “hand‐in‐hand” immunoregulation of early‐stage atherosclerosis. Coated with biomimetic platelet membrane, PGA@PMP can actively target to the pathological endothelium and respond to the reactive oxygen species (ROS) in lesions for further disassembly and releasing photoacoustic probe along with immune‐regulate complex GWAS. The photoacoustic probe performs a noninvasive imaging with distinct recognition of plaques. In company, triggered by local cathepsin B, GWAS can be degraded for respective regulation on inducing M2 macrophages and stimulating regulatory T (Treg) cells. The transforming growth factor beta (TGF‐β) expressed by up‐regulated M2 macrophages also intensifies the Treg cell differentiation, which synergistically inhibits the foam cell formation and rebuilds a well‐balanced immune microenvironment. The in vivo evaluations suggest that the “hand‐in‐hand” strategy on regulating macrophages polarization and T cell differentiation indicates the restraint on atherosclerotic progression and the reversal of formed lesions even under high‐fat diet. Together, PGA@PMP provides an integrated solution for targeting theranostics of early‐stage atherosclerosis and delivers an exciting outcome of reversing the formed lesions.
Isolation and Enrichment of Extracellular Vesicles with Double‐Positive Membrane Protein for Subsequent Biological Studies
Authors: Liu Chunchen , Lin Huixian , Yu Haiyang , Mai Xueying , Pan Weilun , Guo Jingyun , Liao Tong , Feng Junjie , Zhang Ye , Situ Bo , Zheng Lei , Li Bo 
Published: November 2023

AbstractThe isolation and enrichment of specific extracellular vesicle (EV) subpopulations are essential in the context of precision medicine. However, the current methods predominantly rely on a single‐positive marker and are susceptible to interference from soluble proteins or impurities. This limitation represents a significant obstacle to the widespread application of EVs in biological research. Herein, a novel approach that utilizes proximity ligation assay (PLA) and DNA–RNA hybridization are proposed to facilitate the binding of two proteins on the EV membrane in advance enabling the isolation and enrichment of intact EVs with double‐positive membrane proteins followed by using functionalized magnetic beads for capture and enzymatic cleavage for isolated EVs release. The isolated subpopulations of EVs can be further utilized for cellular uptake studies, high‐throughput small RNA sequencing, and breast cancer diagnosis. Hence, developing and implementing a specialized system for isolating and enriching a specific subpopulation of EVs can enhance basic and clinical research in this field.
STAC: A tool to leverage genetic marker data for crop research and breeding
Authors: Carle Scott , Kiszonas Alecia , Garland‐Campbell Kimberly , Morris Craig F. 
Published: November 2023

AbstractAs genotyping by sequencing (GBS) becomes more prevalent and cost‐effective, there is a benefit in being able to apply the data to solve a variety of problems. However, high degrees of missing data and overreliance on single nucleotide polymorphisms (SNPs), while ignoring other forms of genetic variation, frequently plague attempts to make full use of GBS sequence data. Here we have developed two R scripts to serve as a tool in haplotype determination at loci of interest within biparental populations. One of these scripts, Sparse Tag Allele Caller (STAC), provides both automated calling and visual representations of the data around a locus of interest to assist in rapid data compilation decision‐making. The other script, STAC Integrate, allows automated quality control and logic‐based integration of presence/absence data with SNP data, while also rendering global overviews of recombination and coverage across the genome. These scripts are designed to be used together to maximize the utility of the available data. These tools were validated on a biparental population of wheat that was genotyped through GBS. They successfully enabled haplotype determination of a locus that was difficult to directly genotype, and their systemic accuracy was demonstrated in multiple populations and species. These scripts may serve as a tool for researchers attempting to make better use of GBS and other genetic marker data for both research and crop breeding decisions.
Multivariate alarm systems to recognize rare unpostulated abnormal events
Authors: Sudarshan Vikram , Seider Warren D. , Patel Amish J. , Oktem Ulku G. , Arbogast Jeffrey E. 
Published: November 2023

AbstractMost chemical and manufacturing plants have safety/reliability systems in place that are well equipped to handle commonly occurring postulated abnormal events, but often prove to be ineffective in predicting highly unanticipated and randomly occurring unpostulated abnormal events. In this paper, an advisory system is developed to analyze and recognize such events, consisting of novel, multivariate alarm systems and response actions introduced using process modeling and path‐sampling for unpostulated abnormal events. It augments existing safety/reliability systems, suggesting actions when unanticipated abnormal events are approached. Forward‐flux sampling (FFS), developed to discover rare molecular dynamics pathways, is applied. With an approximate process model, for an exothermic continuous‐stirred tank reactor using a perturbed feed concentration, the FFS algorithm is applied to identify rare trajectories between high‐conversion and low‐conversion steady‐states, with key process variables saved at various “crossing points.” Then, committer probabilities, , are computed at each crossing point, yielding a mathematical model that expresses as a function of the key process variables; that is, the reactor temperature (T), cooling‐water flow rate (), and cooling‐water temperature (), selected as choices for the primary alarm variables. For these, alarm thresholds; that is, L—low, LL—low low, and LLL—low low low, are suggested by computing their critical ranges, given the ranges for every alarm threshold.
Directional Defect Management in Perovskites by In Situ Decomposition of Organic Metal Chalcogenides for Efficient Solar Cells
Authors: Wang Guan‐E , Xiao Guo‐Bin , Li Cong‐Ping , Fu Zhi‐Hua , Cao Jing , Xu Gang 
Published: November 2023

AbstractDirectional defects management in polycrystalline perovskite film with inorganic passivator is highly demanded while yet realized for fabricating efficient and stable perovskite solar cells (PSCs). Here, we develop a directional passivation strategy employing a two‐dimensional (2D) material, Cu‐(4‐mercaptophenol) (Cu‐HBT), as a passivator precursor. Cu‐HBT combines the merits of the targeted modification from organic passivator and excellent stability offered by inorganic passivator. Featuring with dense organic functional motifs on its surfaces, Cu‐HBT has the capability to “find” and fasten to the Pb defect sites in perovskites through coordination interactions during a spin‐coating process. During subsequent annealing treatment, the organic functional motifs cleave from Cu‐HBT and convert in situ into p‐type semiconductors, Cu2S and PbS. The resultant Cu2S and PbS not only serve as stable inorganic passivators on the perovskite surface, significantly enhancing cell stability, but also facilitate efficient charge extraction and transport, resulting in an impressive efficiency of up to 23.5 %. This work contributes a new defect management strategy by directionally yielding the stable inorganic passivators for highly efficient and stable PSCs.
Magnetized CNTs incorporated MBA cross‐linked guar gum nano‐composite for methylene blue dye removal
Authors: Sayana K. V. , Prajwal K. , Deeksha K. J. , Vishalakshi B. , Vishwanath T. 
Published: November 2023

AbstractIn the present work, a magnetized multiwalled carbon nanotube dispersed in chemically cross‐linked gaur gum was developed as a nano‐composite adsorbent material for the removal of dye from wastewater. The gaur gum, a bio‐macromolecule was chemically modified by cross‐linking with methylene bis‐acrylamide in the presence of sodium hydroxide as a novel approach to prepare the gel matrix. The magnetite nanoparticles loaded multiwalled carbon nanotubes were dispersed in methylene bis‐acrylamide cross‐linked gaur gum gel during gelation. The nano‐composite was characterized for morphological, spectral, and analytical data. The solid form of the nano‐composite was evaluated as an adsorbent material for the treatment of water containing methylene blue dye molecules as pollutants by the spectrophotometric method. Adsorption isotherm studies suggested that the Freundlich model was the befitting model for adsorption, indicating the multilayered adsorption and the kinetic study revealed the adsorption to occur by a pseudo‐second‐order kinetic process. The novel nano‐composite is found to be a promising material for the adsorptive removal of dye molecules from dye‐contaminated wastewater. The adsorption capacity was observed to be 11 mg/g of the material.