bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postpartum lifestyle behaviour among women with prior gestational diabetes mellitus: evidence from the HUNT study
Authors: Ringvoll Hanne , Kolberg Marit , Rangul Vegar , Hafskjold Ingrid , Haug Eirin Beate , Blomhoff Rune , Henriksen Hege Berg , Horn Julie 
Published: October 2023

IntroductionWomen with a history of gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Recommendations for postpartum follow-up include targeted lifestyle advice to lower the risk.The aim of this study was to compare postpartum lifestyle behaviours and perceptions among women with and without a history of GDM. In addition, we examined whether lifestyle behaviours of women with a history of GDM participating in a lifestyle intervention study differed from lifestyle behaviours of women with a history of GDM in the general population.Research design and methodsWe linked data from the fourth survey of the population-based Trøndelag Health Study (HUNT4) to information from the Medical Birth Registry of Norway for women with registered births between 2000 and 2019. Using logistic regression, we compared lifestyle behaviours in women with and without GDM. In secondary analyses, lifestyle behaviours in women with GDM participating in a postpartum lifestyle intervention study were compared with HUNT participants with GDM using Fisher’s exact tests/t-tests.ResultsA high proportion of the women in our population, regardless of GDM history, reported several unhealthy lifestyle behaviours. We found no significant association between history of GDM and lifestyle behaviours. The lifestyle intervention study for women with a history of GDM appeared to recruit women with more favourable lifestyle behaviours.ConclusionsWomen, regardless of GDM history, could potentially benefit from further support for lifestyle improvement, but it may be especially important in women with a history of GDM given their increased risk of T2DM and CVD. Interventions targeting women with GDM might not reach the women with the unhealthiest lifestyle behaviours, and measures to reach out to all women should be further investigated.
About the performance of perturbative treatments of the spin-boson dynamics within the hierarchical equations of motion approach
Authors: Xu Meng , Ankerhold Joachim 
Published: October 2023

AbstractThe hierarchical equations of motion (HEOM) provide a numerically exact approach for simulating the dynamics of open quantum systems coupled to a harmonic bath. However, its applicability has traditionally been limited to specific spectral forms and relatively high temperatures. Recently, an extended version called Free-Pole HEOM (FP-HEOM) has been developed to overcome these limitations. In this study, we demonstrate that the FP-HEOM method can be systematically employed to investigate higher order master equations by truncating the FP-HEOM hierarchy at a desired tier. We focus on the challenging scenario of the spin-boson problem with a sub-Ohmic spectral distribution at zero temperature and analyze the performance of the corresponding master equations. Furthermore, we compare the memory kernel for population dynamics obtained from the exact FP-HEOM dynamics with that of the approximate Non-Interacting-Blip Approximation (NIBA).
PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages
Authors: Kauffman Kevin , Manfra Denise , Nowakowska Dominika , Zafari Mohammad , Nguyen Phuong A. , Phennicie Ryan , Vollmann Elisabeth H. , O'Nuallain Brian , Basinski Sara , Komoroski Veronica , Rooney Kate , Culyba Elizabeth K. , Wahle Joseph , Ries Carola , Brehm Michael , Sazinsky Steve , Feldman Igor , Novobrantseva Tatiana I. 
Published: October 2023

Abstract

The immune suppressive microenvironment is a major culprit for difficult-to-treat solid cancers. Particularly, inhibitory tumor-associated macrophages (TAM) define the resistant nature of the tumor milieu. To define tumor-enabling mechanisms of TAMs, we analyzed molecular clinical datasets correlating cell surface receptors with the TAM infiltrate. Though P-selectin glycoprotein ligand-1 (PSGL-1) is found on other immune cells and functions as an adhesion molecule, PSGL-1 is highly expressed on TAMs across multiple tumor types. siRNA-mediated knockdown and antibody-mediated inhibition revealed a role for PSGL-1 in maintaining an immune suppressed macrophage state. PSGL-1 knockdown or inhibition enhanced proinflammatory mediator release across assays and donors in vitro. In several syngeneic mouse models, PSGL-1 blockade alone and in combination with PD-1 blockade reduced tumor growth. Using a humanized tumor model, we observed the proinflammatory TAM switch following treatment with an anti-PSGL-1 antibody. In ex vivo patient-derived tumor cultures, a PSGL-1 blocking antibody increased expression of macrophage-derived proinflammatory cytokines, as well as IFNγ, indicative of T-cell activation. Our data demonstrate that PSGL-1 blockade reprograms TAMs, offering a new therapeutic avenue to patients not responding to T-cell immunotherapies, as well as patients with tumors devoid of T cells.

Significance:
This work is a significant and actionable advance, as it offers a novel approach to treating patients with cancer who do not respond to T-cell checkpoint inhibitors, as well as to patients with tumors lacking T-cell infiltration. We expect that this mechanism will be applicable in multiple indications characterized by infiltration of TAMs.
Abstract P161: Addressing Hypertension And Aging In Growing Tribal Afro-pakistani And Indigenous Migrant Populations In San Joaquin
Authors: Siddiqui Maha 
Published: October 2023

Introduction:
San Joaquin Valley (SJV) Pakistani indigenous elderly migrants (SJIEM) and tribal Afro-Pakistani elderly populations (TAPEP) face health problems due to poor nutritional habits, financial and emotional stress from loss of social status, loss of physical capabilities, orthopedic disorders (OD), loneliness, reduced income which can increase risk for hypertension (HTN) and cardiovascular disease (CVD). Pakistan is ranked as the 12th highest source country for immigration into USA. SJV has a growing rate of at risk for HTN in SJIEM and TAPEP who live with their full time working adult children.

Objectives:
Trainees conducted HTN screenings at mosques located in the most medically served region, SJV to reduce CVD risk and spread awareness on HTN, stress management, nutrition, OD, exercise, and their implications in SJIEM and TAPEP.

Methods:
I trained medically ambitious low-income minority high school students to conduct blood pressure screenings with cultural humility and serve as health coaches for SJIM and TAPEP at SJV mosques. HTN screenings, stress management guidance, nutrition and heart health talks were conducted at SJV mosques with Imam (religious leader) for adult children and elderly.

Findings:

-Approximately (≈) 83% (91 of 110) of SJIEM & TAPEP felt financial & emotional stress during COVID and last year
-≈68% (74 of 110) of SJIEM & TAPEP are hypertensive
-≈68% (74 of 110) of SJIEM & TAPEP are at risk for CVD
-≈2% (2 of 110) of SJIEM & TAPEP reported daily physical exercise
-≈12% (13 of 110) of SJIEM & TAPEP were encouraged to physically exercise
-≈90% (99 of 110) of SJIEM & TAPEP suffer from at least one form of OD
-≈95% (105 of 110) of SJIEM & TAPEP eat over 4 servings of red meat per week
-≈94% (103 of 110) of SJIEM & TAPEP prefer to rest than physically exercise
-≈89% (97 of 110) of SJIEM & TAPEP felt dissatisfied by SJV medical treatment

Direct Outcomes:

-Development of self advocacy for health in SJIEM and TAPEP
-Improved patient provider trustAdult children felt more confident in caring for elderly parents with nutrition and physical therapy
-Youth learned the value of multiculturalism and service to disadvantaged communities
-Program students are determined to pursue medicine and address health disparities in indigenous communities
Abstract P195: Association Of Unmet Social Needs With Antihypertensive Medication Prescription And Dietitian Referral: Interim Analysis Of The Study Of The Epidemiology Of Pediatric Hypertension Registry (SUPERHERO)
Authors: Onugha Elizabeth A , Campbell Jessica F , Londeree Jackson , Misurac Jason , Riar Sandeep , Sethna Christine , Siddiqui Sahar , Weaver Donald J , Yamaguchi Ikuyo , Vincent Carol , South Andrew 
Published: October 2023

HTN is a significant public health concern with increasing prevalence in youth. Optimizing BP control with both lifestyle counseling and antihypertensive medications improves health outcomes. However, adequate BP control remains difficult in majority of patients, in part due to a lack of understanding of how social determinants of health affect dietitian referral and initiation of antihypertensive therapy.
We performed a cross-sectional analysis of baseline EHR data from the SUPERHERO Registry in youth who received initial care from sub-specialists for HTN disorders defined by ICD-10 codes from 1/1/2015-12/31/2022. We excluded those with pregnancy, kidney transplantation, and dialysis. We examined the association of individual-level social drivers (transportation, finances, food access housing) with the likelihood of antihypertensive medication prescription and dietitian referral at initial visit in youth with HTN disorders using unadjusted generalized linear models.
Of our large cohort of 11,580, only 47 youth had at least one unmet social need (0.4%). Participants with at least one unmet social need were 1.81 times more likely to be prescribed antihypertensive medication (95% CL 0.94- 3.48; p= 0.08) and 6.73 times more likely to be referred to a dietitian (95% CL 3.7-12.25).
We found that children with at least one unmet social need were more likely to be referred to a dietitian at the initial visit than those without an unmet social need. The small number of participants with unmet social needs might reflect poor screening or documentation practices. It is imperative that screening for unmet social needs is incorporated into clinical practice in youth with HTN disorders.
The Political Costs of Austerity
Authors: Gabriel Ricardo Duque , Klein Mathias , Pessoa Ana Sofia 
Published: October 2023

Abstract
Using a novel regional database covering over 200 elections in several European countries, this paper provides new empirical evidence on the political consequences of fiscal consolidations. To identify exogenous reductions in regional public spending, we use a Bartik-type instrument that combines regional sensitivities to changes in national government expenditures with narrative national consolidation episodes. Fiscal consolidations lead to a significant increase in extreme parties' vote share, lower voter turnout, and a rise in political fragmentation. We highlight the close relationship between detrimental economic developments and voters' support for extreme parties by showing that austerity induces severe deconomic costs through lowering GDP, employment, private investment, and wages. Austerity-driven recessions amplify the political costs of economic downturns considerably by increasing distrust in the political environment.
Torn into the Abyss?
Authors: Niemann Dennis , Krogmann David , Martens Kerstin 
Published: October 2023

Abstract
Recent challenges to the liberal international order (LIO) have called into question the efficacy of international organizations (IO s) in global governance. However, it remains unclear if the anticipated crisis of the LIO affects all policy fields to the same degree. Based on organizational ecology, this article seeks to explain compositions and trajectories across three fields—climate, education, and health. It shows that the three subpopulations of IO s are stable since the early 2000s, while regional IO s constitute a significant share of the subpopulations. It further finds notable variation in the distribution of generalist and specialist IO s. While the number of generalist IO s in relation to specialist health IO s decreased over time, the article finds generalist education and climate IO s have been on the rise. It argues that—as policy issues grow ever more interconnected over time—IO s expand their thematic scopes to new niches.
The Loyal Scholar. Hindūšāh, Naḫjawān and the Juwaynīs
Authors: Durand-Guédy David 
Published: October 2023

Abstract
This article documents intellectual life in Iran under the Mongols through the case of Hindūšāh Naḫjawānī (d. before 728/1327–28), a scholar known primarily as a historian who has gained a certain notoriety thanks to the pioneering works of Edgard Browne and ʿAbbās Iqbāl on his Tajārib al-salaf. New sources allow to rectify a number of approximations and mistakes about his origin, his name, his works, his career and his scholarly interests. The resulting portrait of Hindūšāh illustrates several key features of the scholarly life of medieval Islam in general and of the Ilkhanid period in particular: social mobility (via Hindūšāh’s rise from a Turkish military background to a well-educated scholar), geographical mobility (through his constant travels from his home region of Naḫjawān), linguistic fluidity in his writings (between Persian and Arabic, but without the slightest interest in Turkish), political context (specifically, the increasing “Shiitisation” of the late Ilkhanate), and, last but not least, loyalty to his patrons. Hindūšāh not only enjoyed the protection of the Juwaynī brothers at a time when they wielded tremendous power in the early Ilkhanate state but also remained loyal to their memory decades after their fall in the 680/1280s. It helps explain his disillusioned view of historiographical writing but also his choice of works to copy. Hindūšāh remained an independent scholar, finding solace from distressing historical events in the study of philosophy and the reading of poetry.
Rosa Arciniega and the Transformations of Avant-Garde Fiction
Authors: Herrero-Senés Juan 
Published: October 2023

Abstract
The objective of this article is to provide a reevaluation of Rosa Arciniega’s (1903–1999) literary work in Spain throughout the 1930s. While her work is currently labelled as ‘social literature’, the present study will argue that this label is reductive and does not take into account the complexities, contradictions and transformations of her work. As this article will show, Arciniega sought to represent and express modernity in its most varied facets by focusing on three different areas: social denunciation, renewal of literary expression, and an appeal to romantic sentimentality. This study seeks to shed light on Arciniega’s immersion in time and the consequent grim diagnosis of modernity which led her from left-wing radicalism to more conservative positions. Formal experimentation will be seen as a key part of her literary trajectory.
Integrating Critical Content into an Undergraduate Research Methods Course to Support Student Learning Outcomes
Authors: Calderon Christine , Hines Jarrod C. 
Published: October 2023

Background Undergraduate students have reported low utility for research. Drawing from the literature about motivation and culturally relevant and responsive education, we framed psychological research methods as a social justice tool to enhance learners’ understanding of racial inequality and valuing of course content. Objective Two instructors infused critical methods content throughout their undergraduate psychological research methods courses to increase students’ perceptions of systemic racism in research, multicultural perspective taking, and motivation toward the course. Method Undergraduate students’ attitudes were measured at the beginning and end of the semester using an anonymous online survey. The critical research methods content was integrated throughout the semester. Results Effect sizes provided marginal support for increased awareness of systemic racism in research and multicultural perspective-taking. Results also indicated that students who more strongly perceived research as a social justice strategy reported greater valuing of research, and those who perceived higher value reported greater intentions to pursue research in the future. Conclusion Results provide proof of concept for critical methods content in facilitating undergraduate students’ critical awareness and engagement with psychological research methods.   Teaching Implications Teachers can utilize critical content to support students’ critical engagement and goal setting within their learning contexts.
An Examination of Teachers’ Perceptions of Principal Support for Change and Teachers’ Collaboration and Communication around Literacy Instruction in Reading First Schools
Authors: Berebitsky Dan , Goddard Roger D. , Carlisle Joanne F. 
Published: October 2023

Background/Context Little research has directly examined whether principal leadership can increase the degree to which teachers work together regularly in focused ways around content. Prior research has shown that reform efforts seeking to alter the process of teaching can be successful if teachers collaborate to build capacity and improve instruction. Furthermore, the research literature has highlighted supportive principal leadership as a key component of teachers’ perception of an effective collaborative change process. Purpose This study examines the empirical link between teachers’ perceptions of principal support for change and teachers’ reports of the degree of collaboration and communication with one another around literacy. Setting The data for this study was collected in all 165 Reading First schools in Michigan in the 2006-2007 school year. Subjects Survey data was collected from 1,738 teachers across all schools. Research Design Data for this study was collected as part of the evaluation of Reading First in Michigan. Literacy teachers in kindergarten through third grade completed surveys at three points throughout the school year (fall, winter, and spring). These surveys contained questions about principal support for change and collaboration and communication around literacy. Data Collection and Analysis The primary analytic method employed in this study was multilevel modeling. Factor analysis and full information maximum likelihood estimation were also used. Findings/Results The measure of principal support for change was a significant positive predictor of teachers’ assessment of the degree of regular collaboration and communication around reading instruction; a one standard deviation increase in teachers’ reports of principal support for change was associated with a 0.202 standard deviation increase in teachers’ assessment of the degree of collaboration and communication around literacy when controlling for the other variables in the model. Conclusions/Recommendations This paper demonstrates that the degree to which teachers report collaboration and communication around literacy in Reading First schools is significantly related to their perceptions of principal support for change. If policymakers expect teachers to collaborate around issues of instruction, then they need to consider the principal's role in supporting change in the school by encouraging teachers to improve their instruction and take the risks associated with innovation. In sum, the results of this study are important for educators, as the role of the principal is potentially critical for positive changes in teacher collaboration and, consequently, student achievement in high-poverty schools.
Deep learning to predict esophageal variceal bleeding based on endoscopic images
Authors: Hong Yu , Yu Qianqian , Mo Feng , Yin Minyue , Xu Chang , Zhu Shiqi , Lin Jiaxi , Xu Guoting , Gao Jingwen , Liu Lu , Wang Yu 
Published: October 2023

Objective Esophageal varix (EV) bleeding is a particularly serious complications of cirrhosis. Prediction of EV bleeding requires extensive endoscopy experience; it remains unreliable and inefficient. This retrospective cohort study evaluated the feasibility of using deep learning (DL) to predict the 12-month risk of EV bleeding based on endoscopic images. Methods Six DL models were trained to perform binary classification of endoscopic images of EV bleeding. The models were subsequently validated using an external test dataset, then compared with classifications performed by two endoscopists. Results In the validation dataset, EfficientNet had the highest accuracy (0.910), followed by ConvMixer (0.898) and Xception (0.875). In the test dataset, EfficientNet maintained the highest accuracy (0.893), which was better than the endoscopists (0.800 and 0.763). Notably, one endoscopist displayed higher recall (0.905), compared with EfficientNet (0.870). When their predictions were assisted by artificial intelligence, the accuracies of the two endoscopists increased by 17.3% and 19.0%. Moreover, statistical agreement among the models was dependent on model architecture. Conclusions This study demonstrated the feasibility of using DL to predict the 12-month risk of EV bleeding based on endoscopic images. The findings suggest that artificial intelligence-aided diagnosis will be a useful addition to cirrhosis management.
Flow cytometric signature of CD371-positive B-cell acute lymphoblastic leukemia
Authors: Shakah Hind , Tbakhi Abdelghani , Khudirat Saleh , Abweh Ruba Al , Hasasna Nabil , Alwhaidi Alaa , Khoujah Abdallah , Barakat Fareed 
Published: October 2023

Objectives Multiparametric flow cytometry (MFC) aids in the diagnosis and management of B-cell acute lymphoblastic leukemia (B-ALL) by establishing a baseline immunophenotype for leukemic cells and measuring minimal residual disease (MRD) throughout the course of treatment. Aberrant expression patterns of myeloid markers in B-ALL are also examined during long-term surveillance. Here, we investigated the utility of the newly described myeloid marker cluster of differentiation (CD)371 in MRD surveillance via MFC in patients with CD371-positive B-ALL. Methods Eight-color MFC with standard panels (including CD371) was used to evaluate 238 patients with newly diagnosed B-ALL. Expression levels of key markers were retrospectively assessed at diagnosis, as well as days 15 and 33 of therapy. Results CD371 was expressed in 8.4% of patients with B-ALL. CD371 positivity was associated with older age at diagnosis, higher expression levels of CD34 and CD38, and lower expression levels of CD10 and CD20. Residual leukemic cells demonstrated decreased CD10 expression and increased CD45 expression after therapy, whereas CD371 expression remained stable. Conclusions Patients with CD371-positive B-ALL exhibit a specific signature that merits further analysis, particularly because it has been associated with DUX4 rearrangement.