bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretch broken carbon fiber for primary wind turbine structure
Authors: Cairns D.S , Booth E. , Ridgard C. 
Published: November 2023

Abstract
Stretch broken carbon fiber (SBCF) composites offer significant benefits over conventional continuous fiber composites. These include the greatly enhanced formability of unidirectional tape form products prior to cure without any compromise on the mechanical performance after curing. The recent work performed under the US Army funded Stretch Broken Carbon Fiber for Primary Aircraft Structure program by Montana State University (MSU) is reviewed, along with the results achieved by previous efforts to develop this technology. The achievement of shorter stretch break lengths to improve formability is a principal objective of the work and a successful achievement of the recent efforts. In addition, alternate means of manufacturing SBCF prepregs are discussed, including conventional spooled fiber presentation suitable for running on current prepregging equipment, as well as a newly developed direct to prepreg approach, where the stretch breaking of the fibers is done in-line with the prepregging process. While aerospace primary structure has been the focus of current research efforts, applications in other industries such as wind turbine blades are also obvious areas of applications for SBCF technology.
Exposure to airborne mycotoxins: the riskiest working environments and tasks
Authors: Marcelloni Anna Maria , Pigini Daniela , Chiominto Alessandra , Gioffrè Angela , Paba Emilia 
Published: November 2023

Abstract

Objectives
There is growing interest in the role of airborne mycotoxins in occupational environments, however, their impact on human health still remains poorly investigated. This review aims to provide a comprehensive analysis of the existing literature on the occurrence of inhalable mycotoxins in working environments to investigate which sectors and tasks are at greater risk of exposure.

Methods
We have performed a systematic search in the PubMed, Scopus and Web of Science databases from 2010 to date, without limitation of geographic location.

Results
Database searches yielded 350 articles. After the removal of duplicates and applying our inclusion and exclusion criteria, 31 papers remained. Results show that the most exposed workers are those engaged in activities related to animal care and management and, in particular, in feeding tasks, while harvester cleaning seems to be the activity with the highest levels of exposure in agriculture. In healthcare settings mycotoxin concentrations are low but HVAC systems can be a source of contamination and this reinforces the relevance of further studies in this sector. The most common scenario is the exposure to multiple mycotoxins with variable concentrations depending on the working environment, the products handled or the tasks performed by workers. Some authors emphasize the importance of multi-approach sampling and analysis protocols to achieve an accurate and more realistic risk characterization.

Conclusions
Results brought forward by this review can be utilized by health and safety professionals to recognize activities in which workers may be potentially exposed to airborne mycotoxins and thus undertake suitable preventive and protective measures.
Exogenous spike-in mouse RNAs for accurate differential gene expression analysis in barley using RT-qPCR
Authors: Vinje Marcus A , Friedman David A 
Published: November 2023

Abstract
Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) followed by the 2−ΔΔCt method is the most common way to measure transcript levels for relative gene expression assays. The quality of an RT-qPCR assay is dependent upon the identification and validation of reference genes to normalize gene expression data. The so-called housekeeping genes are commonly used as internal reference genes because they are assumed to be ubiquitously expressed at stable levels. Commonly, researchers do not validate their reference genes but rely on historical reference genes or previously validated genes from an unrelated experiment. Using previously validated reference genes to assess gene expression changes occurring during malting resulted in extensive variability. Therefore, a new method was tested and validated to circumvent the use of internal reference genes. Total mouse RNA was chosen as the external reference RNA and a suite of primer sets to putatively stable mouse genes was created to identify stably expressed genes for use as an external reference gene. cDNA was created by co-amplifying total mouse RNA, as an RNA spike-in, and barley RNA. When using the external reference genes to normalize malting gene expression data, standard deviations were significantly reduced and significant differences in transcript abundance were observed, whereas when using the internal reference genes, standard deviations were larger with no significant differences seen. Furthermore, external reference genes were more accurate at assessing expression levels in malting and developing grains, whereas the internal reference genes overestimated abundance in developing grains and underestimated abundance in malting grains.
Improving Quality in Social Work: The Role of Peer Challenge
Authors: Mahesh Sharanya , Lowther Jason , Miller Robin 
Published: November 2023

Abstract
Network-based approaches to improvement and specifically, peer challenges have become an integral part of quality assurance in adult social work in England. Whilst the national regulation change in 2011 placed greater weight on local accountability, very few studies have examined the contribution of peer challenges towards improving the quality of adult social work practice. Peer challenge is a process of engaging a wide range of people and experienced peers in relevant service areas to offer a review from the perspective of a critical friend. This article considers how a regional peer challenge process in the West Midlands of England contributed to improving social work practice and processes, which supported this contribution. Drawing on data from fifteen interviews and forty-four survey responses, findings suggest that peer challenges in the short term can have positive impacts including, an understanding of the internal practice conditions and external context, strengths and limitations of social work practice, and the perspectives of local stakeholders and external peers on opportunities to improve practice. The design, commitment to transparency and trust by all parties enable honest reflection and a shared learning experience. To understand long-term impacts, we suggest establishing formal follow-up processes together with developing key baseline indicators to track impacts.
Forging lesbians: Sappho and The Songs of Bilitis
Authors: Lambert Cat 
Published: November 2023

Abstract
In Les Chansons de Bilitis (‘The Songs of Bilitis’, 1894), Pierre Louÿs purports to have translated into French for the first time the long-lost Greek poems of Bilitis, a contemporary of Sappho. Classicists have often heralded Bilitis as a watershed moment for reclaiming the lesbian Sappho from the clutches of homophobic, misogynist philologists. This paper complicates this narrative by reframing Bilitis as an object that participates in a broader cultural — and potentially queer — history of forgery. Rather than categorizing Bilitis as a forgery per se, I use forgery (and related textual practices) as a lens for illuminating how Louÿs ‘plays’ the forger and how this performance relates to readers’ divergent desires and reactions. This lens also brings into focus the queer dynamics and effects of this text in relation to Sappho’s corpus. At the same time, following Kadji Amin’s cue to ‘deidealize queerness’ (2017), I show how such queer dynamics are inextricable from colonialist and patriarchal relations of power, in particular an Orientalizing tradition of forgeries by white European and American men. This framework illuminates the affective and political ramifications of forging queer narratives and identifications through the medium of this curious artefact.
‘A series of unfortunate events’: a case report of infective endocarditis resulting from ventricular arrhythmia ablation
Authors: Stec Maria , Dziadosz Dominika , Mizia-Stec Katarzyna 
Published: November 2023

Abstract

Background
Radiofrequency ablation (RFA) is the most effective non-pharmacological approach in the reduction of ventricular tachycardia (VT) recurrence. However, it is crucial to thoroughly screen every patient for contraindications for RFA and provide appropriate pharmacological prophylaxis, if needed, since adverse effects may be fatal.

Case summary
A 77-year-old male with multi-vessel coronary artery disease, heart failure with reduced ejection fraction (New York Heart Association (NYHA) Class III), with implantable cardioverter-defibrillator was admitted to our clinic due to recurrent life-threatening VT. The patient presented several concomitant diseases: dyslipidaemia, hypertension, and chronic kidney disease in Stage IIIB. He had a history of two myocardial infarctions and coronary artery bypass grafts complicated by mediastinitis and dehiscence of a sternotomy scar (2013). Radiofrequency ablation and pace mapping of VT were performed in sterile conditions, but no pre-operative antibiotic prophylaxis was administered. There were no local or general complications in the post-operative period. The patient was discharged from the clinic in good condition. A week later, the patient suffered from septic shock and infective endocarditis of mitral valve complicated with infiltration of the ventricular septum, wall dissection of the left ventricle (LV), pseudoaneurysm, and abscess of the LV. At the time of the second hospitalization extensive dental carries were found and oral cavity sanitation was performed. Due to the severity of the condition, patient did not survive.

Conclusion
Oral cavity infections are common but often overlooked, mainly when the RFA procedure is urgent. A thorough physical examination, including a dental check-up, is crucial to minimize the risk of potential infection of the endocardial tissue and maximize the benefits of the therapy. Still, it is possible that the myocardial infection was not a result of oral cavity infection but a result of other undiagnosed and untreated infection. Contamination of the procedure site with patients’ own microbiota or foreign microorganisms by the medical personnel is also a likely and unfortunate scenario. The presented case highlights the significance of not only prophylaxis, screening, and treatment of possible inflammation sites before RFA but also the need for sustaining sanitary standards and sterile conditions.
Confounding clinical picture in the diagnosis of left ventricular and valvular masses: a case report
Authors: Kharawala Amrin , Chen Yi-Yun , Christian Timothy , Thachil Rosy 
Published: November 2023

Abstract

Background
Masses in the heart and valves have a broad differential diagnosis including infective and rheumatic causes as well as primary or metastatic tumours. Diagnosis involves delineating the location, shape, and origin of the mass/masses and considering the clinical context. This case outlines the work-up and approach to diagnosing a cardiac mass along with imaging findings of a unique secondary metastatic mass in the left ventricle (LV).

Case summary
A 69-year-old female with past medical history of metastatic lung cancer treated with radiotherapy and breast cancer treated with mastectomy presented with dyspnoea and fever. Due to concern for infective endocarditis, transthoracic echocardiogram (TTE) was performed revealing 2 cm × 0.72 cm finger-like, echo-lucent, mobile mass, appearing to originate from LV lateral wall, protruding into the LV cavity, along with valvular masses on mitral and tricuspid valves. Initial differential diagnosis included benign pathologies, but due to the clinical suspicion of malignancy, cardiac MRI was performed which revealed a broad-based mass with invasion into the LV lateral wall and delayed gadolinium enhancement, suggestive of metastatic tumour. The patient was given Aspirin to prevent embolization and eventually underwent hospice care.

Discussion
Atypical appearing cardiac masses can be seen on TTE. Cardiac magnetic resonance imaging (MRI) should be used for definite diagnosis in cases where clinical features do not match the echocardiographic findings.
Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function
Authors: Tang Chao , Li Qiufang , Wang Xiaoya , Yu Zhengwen , Ping Xu , Qin yi , Liu Yang , Zheng Lan 
Published: November 2023

Abstract
The interconnection between cardiac function and circadian rhythms is of great importance. While the role of the biological clock gene Timeless (Tim) in circadian rhythm has been extensively studied, its impact on cardiac function remains largely been unexplored. Previous research has provided experimental evidence for the regulation of the heart by adipose tissue and the targeting of miR-276a/b on Timeless. However, the extent to which adipose tissue regulates cardiac Timeless genes trans-organically through miR-276a/b, and subsequently affects cardiac function, remains uncertain. Therefore, the objective of this study was to investigate the potential trans-organ modulation of the Timeless gene in the heart by adipose tissue through miR-276a/b. We found that cardiac-specific Timeless knockdown and overexpression resulted in a significant increase in heart rate (HR) and a significant decrease in Heart period (HP), diastolic intervals (DI), systolic intervals (SI), diastolic diameter (DD), and systolic diameter (SD). miR-276b systemic knockdown resulted in a significant increase in DI, arrhythmia index (AI), and fractional shortening (FS) significantly increased and SI, DD and SD significantly decreased. Adipose tissue-specific miR-276a/b knockdown and miR-276a overexpression resulted in a significant increase in HR and a significant decrease in DI and SI, which were improved by exercise intervention. This study presents a novel finding that highlights the significance of the heart circadian clock gene Timeless in heart function. Additionally, it demonstrates that adipose tissue exerts trans-organ modulation on the expression of the heart Timeless gene via miR-276a/b.
The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population
Authors: van Eijnatten Abraham L , Sterken Mark G , Kammenga Jan E , Nijveen Harm , Snoek Basten L 
Published: November 2023

Abstract
Regulation of gene expression plays a crucial role in developmental processes and adaptation to changing environments. expression quantitative trait locus (eQTL) mapping is a technique used to study the genetic regulation of gene expression using the transcriptomes of recombinant inbred lines (RILs). Typically, the age of the inbred lines at the time of RNA sampling is carefully controlled. This is necessary because the developmental process causes changes in gene expression, complicating the interpretation of eQTL mapping experiments. However, due to genetics and variation in ambient micro-environments, organisms can differ in their “developmental age,” even if they are of the same chronological age. As a result, eQTL patterns are affected by developmental variation in gene expression. The model organism Caenorhabditis elegans is particularly suited for studying the effect of developmental variation on eQTL mapping patterns. In a span of days, C. elegans transitions from embryo through 4 larval stages to adult while undergoing massive changes to its transcriptome. Here, we use C. elegans to investigate the effect of developmental age variation on eQTL patterns and present a normalization procedure. We used dynamical eQTL mapping, which includes the developmental age as a cofactor, to separate the variation in development from genotypic variation and explain variation in gene expression levels. We compare classical single marker eQTL mapping and dynamical eQTL mapping using RNA-seq data of ∼200 multi-parental RILs of C. elegans. The results show that (1) many eQTLs are caused by developmental variation, (2) most trans-bands are developmental QTLs, and (3) dynamical eQTL mapping detects additional eQTLs not found with classical eQTL mapping. We recommend that correction for variation in developmental age should be strongly considered in eQTL mapping studies given the large impact of processes like development on the transcriptome.
Return Migration and Disability by Life Course Stage of Return: Evidence Against the Salmon Bias
Authors: Sheftel Mara Getz 
Published: November 2023

Abstract

Objectives
Life course theory points to unique characteristics among older immigrants that may differentiate older age return migration from return at younger ages in terms of health. To investigate how the health of returnees may differ by age-at-return, this analysis compares disability between 3 groups of Mexican adults with a history of migration to the United States: those who return to Mexico before age 50, those who return at 50 and older, and those who remain in the United States at age 50 and older.

Methods
Data from two nationally representative data sets, the U.S. Health and Retirement Study and the Mexican Health and Aging Study, are combined to create a data set representing Mexicans 50 and older with a history of migration to the United States. Adopting a life course perspective, activity of daily living (ADL) difficulty is compared by return status and age-at-return to account for differential selection into return by life stage.

Results
Mexican immigrants who remain in the United States past age 50 have a higher probability of at least 1 ADL compared to those who return to Mexico, regardless of life course timing of return. The immigrant disadvantage persists after adjusting for differences in demographic, childhood, and adult characteristics between groups.

Discussion
These findings are noteworthy because they stand in opposition to hypotheses based on life course and health-selective return migration theories and because they mean that Mexican immigrants remaining in the United States into midlife and older adulthood may be vulnerable to heightened prevalence of disability.
Glycans modulate lipid binding in Lili-Mip lipocalin protein: insights from molecular simulations and protein network analyses
Authors: SureshKumar Harini , Appadurai Rajeswari , Srivastava Anand 
Published: November 2023

AbstractThe unique viviparous Pacific Beetle cockroaches provide nutrition to their embryo by secreting milk proteins Lili-Mip, a lipid-binding glycoprotein that crystallises in-vivo. The resolved in-vivo crystal structure of variably glycosylated Lili-Mip shows a classical Lipocalin fold with an eight-stranded antiparallel beta-barrel enclosing a fatty acid. The availability of physiologically unaltered glycoprotein structure makes Lili-Mip a very attractive model system to investigate the role of glycans on protein structure, dynamics, and function. Towards that end, we have employed all-atom molecular dynamics simulations on various glycosylated stages of a bound and free Lili-Mip protein and characterised the impact of glycans and the bound lipid on the dynamics of this glycoconjugate. Our work provides important molecular-level mechanistic insights into the role of glycans in the nutrient storage function of the Lili-Mip protein. Our analyses show that the glycans stabilise spatially proximal residues and regulate the low amplitude opening motions of the residues at the entrance of the binding pocket. Glycans also preserve the native orientation and conformational flexibility of the ligand. However, we find that either deglycosylation or glycosylation with high-mannose and paucimannose on the core glycans, which better mimic the natural insect glycosylation state, significantly affects the conformation and dynamics. A simple but effective distance- and correlation-based network analysis of the protein also reveals the key residues regulating the barrel’s architecture and ligand binding characteristics in response to glycosylation.
SARS-CoV-2 mRNA Vaccines Induce Greater Complement Activation and Decreased Viremia and Nef Antibodies in Men With HIV-1
Authors: Tuttle Dylan J , Castanha Priscila M S , Nasser Amro , Wilkins Maris S , Galarza Tamara García , Alaoui-El-Azher Mounia , Cuff Deirdre E , Chhibbar Prabal , Das Jishnu , Li Yijia , Barratt-Boyes Simon M , Mailliard Robbie B , Sluis-Cremer Nicolas , Rinaldo Charles R , Marques Ernesto T A 
Published: November 2023

Abstract

Background
Immune dysregulation in people with human immunodeficiency virus-1 (PWH) persists despite potent antiretroviral therapy and, consequently, PWH tend to have lower immune responses to licensed vaccines. However, limited information is available about the impact of mRNA vaccines in PWH. This study details the immunologic responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in PWH and their impact on HIV-1.

Methods
We quantified anti-S immunoglobulin G (IgG) binding and neutralization of 3 SARS-CoV-2 variants of concern and complement activation in blood from virally suppressed men with HIV-1 (MWH) and men without HIV-1 (MWOH), and the characteristics that may impact the vaccine immune responses. We also studied antibody levels against HIV-1 proteins and HIV-1 plasma RNA.

Results
MWH had lower anti-S IgG binding and neutralizing antibodies against the 3 variants compared to MWOH. MWH also produced anti-S1 antibodies with a 10-fold greater ability to activate complement and exhibited higher C3a blood levels than MWOH. MWH had decreased residual HIV-1 plasma viremia and anti-Nef IgG approximately 100 days after immunization.

Conclusions
MWH respond to SARS-CoV-2 mRNA vaccines with lower antibody titers and with greater activation of complement, while exhibiting a decrease in HIV-1 viremia and anti-Nef antibodies. These results suggest an important role of complement activation mediating protection in MWH.
Curating Spaces of Hope: A New Paradigm of Postsecular Partnership for Uncertain Times
Authors: Barber-Rowell Matthew 
Published: November 2023

Abstract
In this paper, Curating Spaces of Hope is offered as a new paradigm for postsecular partnership for uncertain times. The need for a new paradigm is set out intially using literatures from faith based organisations. The case is made that the understanding of faith or the ‘F’ is inadequate, and that in order to make sense of the role it plays in social policy, a fresh framing is needed. For this, literatures from political philosophy, sociology or religion and social policy are engaged. These set out the space for mapping different worldviews, as part of the diversifying beleif landscape in the UK, and the policy context into which they are speaking. The paper then turns to empircal data to make the case for the new paradigm of postsecualr partnership, Curating Spaces of Hope. This case is made in three phases. First auto-ethnographic data is used as the basis for a social movement in the north west of England which takes place over 3 years. This is used as the premise for ethnographic research which maps postsecular contexts and informs the production of Curating Spaces of Hope. The paper then turns to the COVID-19 pandemic, as a lens through which to view current contexts of uncertainty. Three case studies are then offered which point to early applications of Curating Spaces of Hope and opportunities for building postsecular partnerships in the north west England.