bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Multimodal Sensing and Feedback Finger Case for Immersive Dual‐Way Interaction
Authors: Chen Tao , Dai Zhiwei , Liu Ming , Zhao Yudong , Ling Hao , Sun Lining , He Haidong , Lee Chengkuo , Zhu Minglu 
Published: January 2024

AbstractWith the rapid development of virtual reality (VR) technology, artificial intelligence , and the Internet of Things , a new era of immersive interaction with the digital world has emerged. In this context, a novel soft finger case with 3D multi‐modal sensing and feedback functions (3D‐SFC) is presented. The device leverages multiple material properties to create a modulated fingertip haptic feedback for the perception of orientation and force, triboelectric nanogenerator (TENG) sensing with dynamic and static responses and control of movement, and thermal feedback based on resistive heating of TENG electrodes. The integrated TENG tactile sensing unit in the device is capable of recognizing the texture of an object's surface, providing users with a more natural and intuitive way of interacting with digital objects. The spatial consistency of multi‐modal sensing and feedback enhances human‐machine interaction in various fields such as healthcare, manufacturing and assembly, and gaming, etc. The proposed device represents a new intelligent sensing solution for achieving cross‐space sensory interaction, opening up new possibilities for the future of VR and digital interaction.
Seamless Integration of Conducting Hydrogels in Daily Life: From Preparation to Wearable Application
Authors: Imani Kusuma Betha Cahaya , Dodda Jagan Mohan , Yoon Jinhwan , Torres Fernando G. , Imran Abu Bin , Deen G. Roshan , Al‐Ansari Renad 
Published: January 2024

AbstractConductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited for applications in skin‐contact electronics and biomedical devices owing to their high biocompatibility and conformality. Although highly conductive hydrogels for smart wearable devices are extensively researched, a detailed summary of the outstanding results of CHs is required for a comprehensive understanding. In this review, the recent progress in the preparation and fabrication of CHs is summarized for smart wearable devices. Improvements in the mechanical, electrical, and functional properties of high‐performance wearable devices are also discussed. Furthermore, recent examples of innovative and highly functional devices based on CHs that can be seamlessly integrated into daily lives are reviewed.
Overproduction of cordycepin in Saccharomyces cerevisiae by cordycepin synthase screening and metabolic engineering
Authors: Wang Haibin , Fu Xiaomeng , Zuo Xiaoru , Zhang Chuanbo , Lu Wenyu 
Published: January 2024

AbstractCordycepin (COR) has attracted extensive attention for its medical value. Currently, separation and extraction from Cordyceps militaris is the main way to obtain COR, but it is time‐consuming and low efficiency. Heterologous synthesis of COR holds great promise for its industrial production. In this work, five COR synthases of different sources were obtained by homology screening, and were integrated into the genome of BY4741. Fermentation and determination of COR found that EA1 and EA2 from Emericellopsis atlantica were more suitable for COR synthesis. Then, ADO1 gene encoding adenosine kinase was knocked down, ADE4 gene encoding amidophosphoribosyltransferase and truncated cpdBN gene encoding 2′,3′‐cyclic‐nucleotide 2′‐phosphodiesterase/3′‐nucleotidase were overexpressed to enhance the accumulation of COR. Finally, the COR titer reached 725.16 mg L−1 in 5‐L bioreactor. This study lays a foundation for the heterologous synthesis and industrial production of COR, and also provides a reference for heterologous synthesis of other high value‐added chemicals.
The ecological value of fully enforced, no‐entry, marine protected areas: A case study of harvested limpets
Authors: Faria João , Vale Maria , Ribeiro Pedro , Hawkins Stephen J. , Martins Gustavo M. 
Published: January 2024

Abstract
Harvesting of intertidal gastropods can lead to a direct reduction in the biomass of targeted species through a reduction in the numbers and size of individuals, in turn leading to extensive changes to the structure of intertidal communities.
In the Azores, two patellid species co‐occur, and both are exploited for human consumption. However, one of these species, Patella aspera (Röding, 1798), is larger and has a greater economic value and is thus favoured in comparison to the smaller Patella candei (d'Orbigny, 1840).
This study investigates the effects of human exploitation on the interaction between these two species by comparing their densities and sizes within two areas of a marine protected area (MPA): a no‐entry area where human access is strictly prohibited and an adjacent area where human access is allowed and collection still occurs despite it being prohibited.
Patella aspera attained similar densities in the two areas, but individuals were much larger within the no‐entry MPA. In contrast, P. candei were more abundant in the adjacent area but were of a similar size as in the no‐entry MPA. Limpet biomass was much greater within the no‐entry MPA. The abundance (% cover) of upright macroalgae and barnacles as well as bare rock were also significantly reduced within the no‐entry MPA, where grazer‐resistant algal crusts cover was significantly greater.
This study highlights the influence of human activities and how these may affect the complex dynamics of biotic interactions with wider community‐level cascading effects.
Cellulose nanocrystals from celery stalk as quercetin scaffolds: A novel perspective of human holo‐transferrin adsorption and digestion behaviours
Authors: Arman Samaneh , Hadavi Marzieh , Rezvani‐Noghani Azadeh , Bakhtparvar Anashid , Fotouhi Melika , Farhang Ali , Mokaberi Parisa , Taheri Reza , Chamani Jamshidkhan 
Published: January 2024

AbstractIn this study, cellulose nanocrystals (CNCs) were synthesized from celery stalks to be used as the platform for quercetin delivery. Additionally, CNCs and CNCs–quercetin were characterized using the results of scanning electron microscope (SEM), transmission electron microscopy (TEM), X‐ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and zeta potential, while their interactions with human holo‐transferrin (HTF) were also investigated. We examined their interaction under physiological conditions through the exertion of fluorescence, resonance light scattering, synchronized fluorescence spectroscopy, circular dichroism, three‐dimensional fluorescence spectroscopy, and fluorescence resonance energy transfer techniques. The data from SEM and TEM exhibited the spherical shape of CNCs and CNCs–quercetin and also, a decrease was detected in the size of quercetin‐loaded CNCs from 676 to 473 nm that indicated the intensified water solubility of quercetin. The success of cellulose acid hydrolysis was confirmed based on the XRD results. Apparently, the crystalline index of CNCs–quercetin was reduced by the interaction of CNCs with quercetin, which also resulted in the appearance of functional groups, as shown by FTIR. The interaction of CNCs–quercetin with HTF was also demonstrated by the induced quenching in the intensity of HTF fluorescence emission and Stern–Volmer data represent the occurrence of static quenching. Overall, the effectiveness of CNCs as quercetin vehicles suggests its potential suitability for dietary supplements and pharmaceutical products.
Kinetic Resolution of Secondary Alcohols Catalyzed at the Exterior of Chiral Coordinated Capsules
Authors: Harada Kentaro , Sekiya Ryo , Haino Takeharu 
Published: January 2024

AbstractConfined spaces inside molecular hosts can function as reaction vessels. However, this concept significantly limits the scope of reactants. When the exterior of molecular hosts is used instead, we can ease the restriction because reactants are not necessary to be trapped inside molecular hosts, although studies along this line have not been reported. As a proof‐of‐concept of enantioselective reactions at the exterior of chiral molecular hosts, we utilized host‐guest complexes of enantiomerically enriched Cu‐coordinated capsules and guests possessing a catalytic center to realize the kinetic resolution of secondary alcohols. Under suitable reaction conditions, a selectivity factor of 2.6 was realized, demonstrating that the reactions occur at the exterior of the capsules. A series of experiments indicated that the substituents on the 2,2’‐bipyridyl arms and the alkyl chains on the lower rim contributed to the enantioselectivity of the reactions.
Distributed temporal–spatial neighbourhood enhanced variational autoencoder for multiunit industrial plant‐wide process monitoring
Authors: Yao Zongyu , Jiang Qingchao , Gu Xingsheng , Pan Chunjian 
Published: January 2024

AbstractProcess monitoring plays an essential role in ensuring the safe and efficient operation of multi‐unit plantwide industrial processes. However, complicated nonlinear dynamics of these processes pose enormous challenges to the plantwide process monitoring approaches. In this paper, a novel distributed temporal–spatial neighbourhood enhanced variational autoencoder (DTS‐VAE) monitoring scheme is proposed. The scheme selects the temporal and spatial neighbourhood sets of a current sample from a local unit. Time‐series correlation is utilized to construct temporal representative samples to obtain process dynamic characteristics. Likewise, spatial similarity is employed to construct spatial representative samples to obtain spatial patterns in the data. Then the reconstructed and current samples serve as the inputs for a variational autoencoder to extract features from the current sample and its neighbourhoods. Subsequently, a distributed monitor that considers the temporal–spatial characteristics is established for each unit. Finally, a comprehensive evaluation index is developed using Bayesian fusion strategy to improve monitoring performance. The proposed DTS‐VAE monitoring scheme was effectively verified on the Tennessee Eastman benchmark process and a wastewater treatment plant.
Ozone oxidation of nitric oxide: Promoting effect of phosphorus and inhibitory effect of phosphoric acid
Authors: Yang Fen , Tian Senlin , Ning Ping , Wang Borui , Xiang Yangcun , Song Xin , Yang Hao 
Published: January 2024

AbstractThis work presents experimental and density functional theory theoretical methods to carry out the catalytic role and reaction mechanism of phosphorus (P4) for liquid phase catalytic oxidation nitric oxide. Meanwhile, it carries out the promoting effect of phosphorus and inhibitory effect of phosphoric acid in the ozone oxidation of nitric oxide. The work reveals the significant involvement of P4 in facilitating the NO catalytic oxidation process by generating O3. Meanwhile, the presence of phosphoric acid (H3PO4) hindered the NO catalytic removal process. The calculation results highlight that P4 promoted the formation of O3 and favoured the oxidation pathway (oxidation‐hydration, NO ➔ NO2 ➔ HNO3). During the liquid‐phase NO catalytic removal process, O2 and NO dissolved into the solution, where O2 exhibited preferential adsorbed on P4, promoting the O3 formation. Subsequently, O3 first oxidized NO to NO2. Then, HNO2 and HNO3 were generated under the hydration reaction of NO2 and H2O. Next, O3 further oxidized the generated HNO2 to HNO3, realizing the complete oxidation of NO. The hydration step of NO2 was identified as the key step in the O3 oxidation processes. Furthermore, the generation of H3PO4 led to the consumption of P4 and inhibited the NO removal process. O3 played the crucial role in liquid phase NO oxidation.
Exploring Unconventional σ‐Hole Interactions: Computational Insights into the Interaction of XeO3 with Non‐Aromatic Coordinating Solvents
Authors: Dash Soumya Ranjan , Vanka Kumar 
Published: January 2024

AbstractIn order to control the explosiveness and shock sensitivity of XeO3, we have investigated its plausible interaction with various non‐aromatic coordinating solvents, serving as potential Lewis base donors, through density functional theory (DFT) calculations. Out of twenty six such solvents, the top ten were thus identified and then thoroughly examined by employing various computational tools such as the mapping of the electrostatic potential surface (MESP), Wiberg bond indices (WBIs), non‐covalent interaction (NCI) plots, Bader's theory of atoms‐in‐molecules (AIM), natural bond orbital (NBO) analysis, and the energy decomposition analysis (EDA). The amphoteric nature of XeO3 was also explored by investigating the extent of back donation from the lone pair of Xe to the antibonding orbital of the donating atom/group of the solvent molecules. The C−H…O interactions were also found to be a contributing factor in the stabilization of these adducts. Although these aerogen‐bonding interactions were found to be predominantly electrostatic, significant contributions from the orbital contributions, as well as dispersion interactions, were observed. The top three non‐aromatic solvents (among the twenty six studied) which form the strongest adducts with XeO3 are proposed to be hexamethylphosphoramide (HMPA), N,N′‐dimethylpropyleneurea (DMPU) and tetramethylethylenediamine (TMEDA).
Isomerization dynamics of a novel cis/trans‐only merocyanine
Authors: Blaise Nadine , Green James A. , Benitez‐Martin Carlos , Kaiser Christoph , Braun Markus , Schaible Jonas M. , Andréasson Joakim , Burghardt Irene , Wachtveitl Josef 
Published: January 2024

AbstractMerocyanines (MC) usually adopt ring opened zwitterionic structures that are interconvertible with their ring‐closed spiropyran photoisomers. By methylating the phenolate oxygen, and thereby blocking the ring‐closure reaction, a cis/trans‐only MC photoswitch was obtained, yielding a perfect candidate for a detailed examination of the cis/trans isomerization mechanism for this class of compounds. This photoswitch displays outstanding properties including excellent photoreaction quantum yields and photoswitching turnovers. Due to the central polymethine bridge of MC, in principle eight cis (C)/trans/(T) isomers are possible. Density Functional Theory (DFT) calculations revealed the CCT and TTT‐isomers of the studied compound as most stable cis and trans ground state isomers, respectively. UV/vis transient absorption studies combined with conical intersection computations with the complete active space self‐consistent field (CASSCF) method show that both trans/cis‐ and cis/trans‐photoisomerizations are initiated by a rotation of the central doubled bond fragment. A hot ground state species is then formed, which undergoes a second isomerization. Thus, the cis/trans reaction proceeds via a CCT‐CTT‐TTT sequence and the reverse reaction via TTT‐TCT‐CCT.
Inhibition of TGFβ1 activation prevents radiation‐induced lung fibrosis
Authors: Yi Minxiao , Yuan Ye , Ma Li , Li Long , Qin Wan , Wu Bili , Zheng Bolong , Liao Xin , Hu Guangyuan , Liu Bo 
Published: January 2024

AbstractBackgroundRadiotherapy is the main treatment modality for thoracic tumours, but it may induce pulmonary fibrosis. Currently, the pathogenesis of radiation‐induced pulmonary fibrosis (RIPF) is unclear, and effective treatments are lacking. Transforming growth factor beta 1 (TGFβ1) plays a central role in RIPF. We found that activated TGFβ1 had better performance for radiation pneumonitis (RP) risk prediction by detecting activated and total TGFβ1 levels in patient serum. αv integrin plays key roles in TGFβ1 activation, but the role of αv integrin‐mediated TGFβ1 activation in RIPF is unclear. Here, we investigated the role of αv integrin‐mediated TGFβ1 activation in RIPF and the application of the integrin antagonist cilengitide to prevent RIPF.MethodsItgavloxP/loxP;Pdgfrb‐Cre mice were generated by conditionally knocking out Itgav in myofibroblasts, and wild‐type mice were treated with cilengitide or placebo. All mice received 16 Gy of radiation or underwent a sham radiation procedure. Lung fibrosis was measured by a modified Ashcroft score and microcomputed tomography (CT). An enzyme‐linked immunosorbent assay (ELISA) was used to measure the serum TGFβ1 concentration, and total Smad2/3 and p‐Smad2/3 levels were determined via Western blotting.ResultsConditional Itgav knockout significantly attenuated RIPF (p < .01). Hounsfield units (HUs) in the lungs were reduced in the knockout mice compared with the control mice (p < .001). Conditional Itgav knockout decreased active TGFβ1 secretion and inhibited fibroblast p‐Smad2/3 expression. Exogenous active TGFβ1, but not latent TGFβ1, reversed these reductions. Furthermore, cilengitide treatment elicited similar results and prevented RIPF.ConclusionsThe present study revealed that conditional Itgav knockout and cilengitide treatment both significantly attenuated RIPF in mice by inhibiting αv integrin‐mediated TGFβ1 activation.Highlights
Activated TGFβ1 has a superior capacity in predicting radiation pneumonitis (RP) risk and plays a vital role in the development of radiation‐induced pulmonary fibrosis (RIPF).
Conditional knock out Itgav in myofibroblasts prevented mice from developing RIPF.
Cilengitide alleviated the development of RIPF by inhibiting αv integrin‐mediated TGFβ1 activation and may be used in targeted approaches for preventing RIPF.
Utility and advantage of the unroofing technique for gastrointestinal subepithelial tumors: A multicenter retrospective cohort study
Authors: Yamamoto Masashi , Nishida Tsutomu , Uema Ryotaro , Kanesaka Takashi , Ogawa Hiroyuki , Kitamura Shinji , Iijima Hideki , Nagai Kengo , Tsutsui Shusaku , Komori Masato , Yamamoto Katsumi , Tsujii Yoshiki , Hayashi Yoshito , Takehara Tetsuo 
Published: January 2024

AbstractBackground and aimVarious techniques for direct biopsy from gastrointestinal subepithelial tumors (SETs) have been reported, although no standard method has been established. A common feature of these techniques is the removal of overlaying mucosa to enable direct biopsies from the SETs. These methods have been synthesized under the collective term “unroofing technique”. We conducted a multicenter retrospective study to assess its efficacy and identify potential complications.MethodsThis study was conducted in 10 hospitals and involved all eligible patients who underwent unroofing techniques to obtain biopsies for gastrointestinal SETs between April 2015 and March 2021. The primary endpoint was the diagnostic accuracy of the unroofing technique, and the secondary endpoints were the incidence of adverse events and the factors contributing to the accurate diagnosis.ResultsThe study included 61 patients with 61 gastrointestinal SETs. The median tumor size was 20 mm, and the median procedure time was 38 min, with 82% successful tumor exposure. The rate of pathological diagnosis was 72.1%. In 44 patients with a pathological diagnosis, two showed discrepancies with the postresection pathological diagnosis. No factors, including facility experience, organ, tumor size, or tumor exposure, significantly affected the diagnostic accuracy. There was one case of delayed bleeding and two cases of perforation.ConclusionThe diagnostic yield of the unroofing technique was acceptable. The unroofing technique was beneficial regardless of institutional experience, organ, tumor size, or actual tumor exposure.
Three novel mononuclear 4‐vinylpyridine‐based Fe(III) complexes displaying various spin‐crossover behaviour
Authors: Jiang Nan , Chen Peng , Liu Zhi‐Kun , Luo Rong , Wu Xue‐Ru , Fan Yu‐Hua , Shao Feng 
Published: January 2024

AbstractThree novel mononuclear 4‐vinylpyridine‐based Fe(III) complexes [FeL(4‐VP)]BPh4 (4‐VP=4‐vinylpyridine; H2L=bis(salicylicdeneaminopropyl)amine, H2salten, 1; H2L=bis(salicylicdeneaminopropyl)methylamine, H2saltenMe, 2; H2L=bis(3‐methoxysalicylideneaminopropyl)methylamine, 3‐OMeH2saltenMe, 3) were synthesized and characterized. Single‐crystal X‐ray diffraction analyses revealed that 1–3 both present the mononuclear structure based on 4‐VP coordinated with bis(salicylicdeneaminopropyl)amine and its derivatives, which give 2D architectures by various interactions among cations and counter‐ions. Magnetic studies showed that both 1 and 2 exhibit one‐step complete spin‐crossover (SCO) behaviours with critical transition temperatures (T1/2) of 178 and 87 K respectively, while 3 exhibits one‐step incomplete spin crossover behaviour (T1/2,3=93 K). The introduction of methyl groups on the amine nitrogen of the Schiff base ligands in 2 and 3 give the bigger repulsive effect, further decrease the cooperation of spin centres, resulting in their spin transition occurring at lower temperatures. In addition, the presence of C−H⋯O weak interactions in 1 and 3 with synergistic effect, led to their spin transition temperatures being higher than that of 2.
Feasibility of using virtual reality in geriatric psychiatry
Authors: Just Sandra Anna , Lütt Alva , Siegle Paula , Döring‐Brandl Eva Janina 
Published: January 2024

AbstractObjectivesVirtual Reality‐based interventions have become an important element of digital mental health, offering accessible and scalable treatment options. However, studies on VR‐based approaches in elderly patients are scarce. This explorative study examined the feasibility of using Virtual Reality (VR) for elderly patients with psychiatric illness, focusing on the sense of presence as the primary outcome.MethodsThe study included N = 30 patients between the ages of 59–92 years who were currently in geriatric psychiatric inpatient and day clinic treatment. Participants were assessed before, during and after a relaxing ten‐minute VR experience. Attitude towards digital media and VR, subjective digital competence, and previous experience were examined using questionnaires. Motion sickness was measured repeatedly during the VR experience using the Fast Motion Sickness Scale (FMS). Patients rated their motion sickness and their general well‐being in the virtual environment. Sense of presence in the virtual environment was quantified with the Igroup Presence Questionnaire (IPQ).ResultsParticipants reported a notable sense of presence (M = 0.41 ± 1.4) in the virtual environment, particularly in terms of spatial presence. Motion sickness was reported by a minority of patients. Three patients terminated the VR application before it was finished. The average well‐being during the VR experience was reported as high (70/100). Sense of presence and motion sickness showed a significant negative correlation. Presence, motion sickness and well‐being were not significantly correlated with age, nor did they differ significantly between groups.ConclusionsThis study underscores the potential of VR‐based experiences in the treatment of elderly psychiatric patients and highlights their willingness and ability to engage with VR technology. While the results are promising, future research should explore more interactive VR scenarios and assess their safety and feasibility in elderly populations.