bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes to balance dynamics following a high-intensity run are associated with future injury occurrence in recreational runners
Authors: Aquino Mariana R. C. , Liddy Joshua J. , Napoli C. Dane , Fonseca Sérgio T. , van Emmerik Richard E. A. , Busa Michael A. 
Published: November 2023

Background: Fatigue is associated with increased injury risk along with changes in balance control and task performance. Musculoskeletal injury rates in runners are high and often result from an inability to adapt to the demands of exercise and a breakdown in the interaction among different biological systems. This study aimed to investigate whether changes in balance dynamics during a single-leg squat task following a high-intensity run could distinguish groups of recreational runners who did and did not sustain a running-related injury within 6 months.Methods: Thirty-one healthy recreational runners completed 60 s of single-leg squat before and after a high-intensity run. Six months after the assessment, this cohort was separated into two groups of 13 matched individuals with one group reporting injury within this period and the other not. Task performance was assessed by the number of repetitions, cycle time, amplitude, and speed. To evaluate balance dynamics, the regularity and temporal correlation structure of the center of mass (CoM) displacements in the transverse plane was analyzed. The interaction between groups (injury, non-injured) and time (pre, post) was assessed through a two-way ANOVA. Additionally, a one-way ANOVA investigated the percent change difference of each group across time.Results: The injured group presented more regular (reduced entropy; 15.6%) and diffusive (increased short-term persistence correlation; 5.6%) CoM displacements after a high-intensity run. No changes were observed in the non-injured group. The within-subject percent change was more sensitive in demonstrating the effects of fatigue and distinguishing the groups, compared to group absolute values. No differences were observed in task performance.Discussion: Runners who were injured in the future demonstrate changes in balance dynamics compared to runners who remain injury-free after fatigue. The single-leg squat test adopted appears to be a potential screening protocol that provides valuable information about balance dynamics for identifying a diminished ability to respond to training and exercise.
Trends and patterns in the global burden of intracerebral hemorrhage: a comprehensive analysis from 1990 to 2019
Authors: Sun Tong , Yuan Yikai , Wu Ke , Zhou Yicheng , You Chao , Guan Junwen 
Published: November 2023

ObjectiveIntracerebral hemorrhage (ICH) is a significant cause of global mortality and morbidity. This study aimed to analyze the burden of ICH and its variation trends across 204 countries and territories from 1990 to 2019.Materials and methodsThe study population comprised individuals of all ages and genders with ICH in 204 countries and regions between 1990 and 2019. Utilizing data from the Global Burden of Disease (GBD) study 2019, we collected information on age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and disability-adjusted life-years (DALYs) rate, which were compared by age, gender, and socio-demographic index (SDI).ResultsIn 2019, there were an estimated 3.4 million (3.0–3.9) incident cases, resulting in 2.8 million (2.6–3.0) deaths and 68.5 million (63.2–73.6) DALYs due to ICH. Between 1990 and 2019, the absolute number of incident cases, deaths, and DALYs increased by 43.0% (41.0–45.0), 37.0% (22.0–51.0), and 25.0% (12.0–36.0), respectively. However, the ASIR, ASDR, and DALYs showed a decreasing trend of-29.0% (−28.0 to −30.0), −36.0% (−29.0 to −43.0), and − 37.0% (−43.0 to −31.0), respectively. Countries with lower SDI tended to have higher ASIR, ASDR, and DALY rates.ConclusionWhile the ASDR and DALY rates decreased from 1990 to 2019, the decline in ASIR was less pronounced. The global burden of ICH remains high, exhibiting significant variation across different genders, age groups, and SDI levels.
Preoperative radiotherapy does not improve and may even be detrimental to the long-term prognosis of patients diagnosed with stage III colon adenocarcinoma: a propensity score-matched SEER database analysis
Authors: Xu Jinyi , Niu Xiaoqiang 
Published: November 2023

BackgroundCurrently, for patients with colon adenocarcinoma who are diagnosed with local lymph node metastasis, it is typically recommended to undergo neoadjuvant treatment before undergoing curative surgical intervention. Nowadays, the focus of preoperative adjuvant therapy for colon adenocarcinoma patients mainly revolves around chemotherapy, and the impact of preoperative radiotherapy on long-term prognosis remains uncertain.MethodsWe extracted data from the Surveillance, Epidemiology, and End Results database for patients with stage III colon adenocarcinoma between 2004 and 2019. Using propensity score matching (PSM), the patients were divided into a preoperative radiotherapy group and a non-preoperative radiotherapy group, and the differences in Kaplan-Meier (KM) survival curves between the two groups were compared. Cox regression analysis was employed to identify clinical factors that influence survival in stage III colon adenocarcinoma, and the prognostic differences between the two groups were compared within specific subgroups of these clinical factors.ResultsAfter PSM, a total of 242 patients were included in the study, divided into the preoperative radiotherapy group and the non-preoperative radiotherapy group. There were no statistically significant differences in important clinical characteristics between the two groups. KM analysis revealed no statistically significant difference in overall survival (OS) between the two groups. Furthermore, age, chemotherapy, T staging, N staging, race, tumor grade, gender, tumor location, and tumor diameter were identified as important factors influencing the prognosis of patients. Within each level of the aforementioned subgroups, there were no differences in OS between the two groups. In fact, in specific subgroups, the non-preoperative radiotherapy group exhibited better OS than the preoperative radiotherapy group.ConclusionPreoperative radiotherapy does not improve the long-term prognosis of patients with stage III colon adenocarcinoma. In certain patient populations with specific clinical characteristics, preoperative radiotherapy may even lead to a decrease in OS.
Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines
Authors: Casotti Chiara , Hattinger Claudia Maria , Patrizio Maria Pia , Luppi Silvia , Fantoni Leonardo , Pasello Michela , Scotlandi Katia , Ibrahim Toni , Serra Massimo 
Published: November 2023

Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related toxicity in pharmacogenetic studies, their role in the development of MTX resistance in HGOS is still unclear.Methods: Therefore, in this study, 22 single nucleotide polymorphisms (SNPs) in 4 genes of the folate metabolism, 7 MTX transporter genes, and 2 SNPs of the tumor protein p53 (TP53) gene were investigated using a custom multimodal-targeted next-generation sequencing (mmNGS) approach in 8 MTX-resistant and 12 MTX-sensitive human HGOS cell lines. The panel was validated by TaqMan genotyping assays.Results: High instability of TP53 rs1642785 was observed in all U-2OS/MTX variants. Allele changes of the solute carrier family 19 member 1/replication factor C subunit 1 (SLC19A1, previously known as RFC1) and rs1051266 were identified in all Saos-2/MTX-resistant variants in both DNA- and RNA- derived libraries compared to the parental Saos-2 cell line. Allele changes of methylenetetrahydrofolate reductase (MTHFR) rs1801133 were identified only in the RNA-derived libraries of the two U2OS variants with the highest MTX resistance level. Significantly upregulated gene expression associated with the development of MTX resistance was revealed for dihydrofolate reductase (DHFR) whereas SLC19A1 was downregulated. In addition, a fusion transcript of DHFR (ex4) and MutS Homolog 3 (MSH3) (ex9) was identified in the RNA libraries derived from the two U-2OS variants with the highest MTX resistance level.Conclusion: This innovative mmNGS approach enabled the simultaneous exploration of SNPs at DNA and RNA levels in human HGOS cell lines, providing evidence of the functional involvement of allele changes associated with the development of MTX resistance.
Storage of boar semen at 17°C without conventional antibiotics in an extender containing an organic bactericidal substance
Authors: Luther Anne-Marie , Nguyen Thu Quynh , Verspohl Jutta , Waberski Dagmar 
Published: November 2023

IntroductionFacing the global threat of antimicrobial resistance, the reduction of antibiotic use in semen extenders is a main goal in artificial insemination (AI) of pigs. The aim of this study was to investigate the potential of a commercial extender containing an organic bactericidal supplement in the absence of conventional antibiotics to control bacterial growth and to maintain the quality of boar spermatozoa during long-term semen storage for up to 144 h at 17°C.MethodsSemen from 233 boars housed at 16 European AI centers was split and diluted in the long-term extender “Androstar Plus without antibiotics + organic bactericidal supplement” (APlus) and in the control extender Beltsville Thawing Solution (BTS) with gentamicin, which is routinely used in many AI centers. Sperm motility was assessed with computer-assisted semen analysis (CASA) and membrane integrity was evaluated with flow cytometry. The number of bacteria was determined by counting colonies on agar plates.ResultsAt the end of storage, bacterial counts were ≥ 106 CFU/mL in 10.7% of the APlus and in 0.4% of the BTS samples. At the same time, bacterial counts were only weakly correlated with sperm motility (r = −0.23, p &lt; 0.05), and there was no correlation with sperm membrane integrity (p &gt; 0.05). Among the 12 identified bacterial species in APlus samples, loss of sperm quality was exclusively observed in the presence of &gt;106 CFU/mL Serratia marcescens and Klebsiella oxytoca. Both these bacterial species, despite their known multi-drug resistance and the continuous use of gentamicin in Europe, proved sensitive to this antibiotic, thus indicating an efficient quality assurance program and responsible antibiotic use.ConclusionLong-term storage of boar semen at 17°C without conventional antibiotics in an extender containing an organic bactericidal supplement is an option if semen samples are regularly tested for the presence of S. marcescens and K. oxytoca, and the source of contamination is eliminated.
Evaluation of Black Soldier Fly Hermetia illucens as Food for Pink-Spotted Lady Beetle Coleomegilla maculata
Authors: Riddick Eric W. , Walker Ryan C. , Rojas Maria Guadalupe , Morales-Ramos Juan A. 
Published: November 2023

The discovery of new and improved factitious and artificial diets is necessary for cost-effective rearing of predatory arthropods. This study evaluated Hermetia illucens black soldier fly (BSF) as a suitable alternative food source for rearing the predatory coccinellid Coleomegilla maculata (Cmac). The hypothesis that BSF larval powder was suitable food to support the growth, development, and reproduction of Cmac was tested in the laboratory. When compared to a standard in-house diet containing brine shrimp egg powder plus Chlorella vulgaris green algae and myristic acid (BSE+CM), the BSF and BSF+CM diets reduced immature growth and development. Immatures successfully reared to teneral adults were smaller when fed BSF or BSF+CM rather than BSE+CM. Combining BSF with a powdered artificial diet (AD), i.e., BSF+AD, did not improve predator growth or development, compared to Cmac reared on BSE+CM. Cmac oviposition responses, i.e., egg clutch production, to BSF vs. BSE+CM or BSF+AD vs. BSE+CM did not differ significantly. In conclusion, BSF has the potential to be food that supports Cmac oviposition behavior. Future research is necessary to discover an ideal mixture of BSF, BSE+CM, or AD that supports Cmac growth, development, and reproduction over multiple generations.
Adaptação cultural e equivalência semântica do Incivility in Nursing Education – Revised Survey
Authors: Ribeiro Vanessa dos Santos , Zamarioli Cristina Mara , Garbuio Danielle Cristina , Miyazaki Margareth Yuri , Santos Claudia Benedita dos , Carvalho Emilia Campos de 
Published: November 2023

Objetivo: realizar a adaptação cultural e a equivalência semântica do Incivility in Nursing Education – Revised Survey para a cultura brasileira. Método: pesquisa metodológica realizada em uma escola paulista de enfermagem e que contou com as seguintes etapas: tradução, síntese das traduções, retrotradução, análise por comitê de especialistas, teste na população-alvo e apresentação da versão final à autora. A avaliação semântica para o idioma português do Brasil com a população-alvo seguiu o método DISABKIDS®. Resultados: obteve-se uma versão traduzida com poucas divergências da versão original. A equivalência semântica apontou poucos itens de dificuldade, e as sugestões dos 21 estudantes de enfermagem que participaram dessa etapa foram essenciais para ajustes em três itens. A versão brasileira é composta por 24 itens referentes a comportamentos de estudantes e outros 24 a comportamentos de professores, representando os níveis alto e baixo de incivilidade. A versão final também conta com questões de múltipla escolha e questões descritivas para caracterizar o fenômeno na instituição e propor alternativas de enfrentá-lo. Esta versão apresenta grande similaridade à versão original e foi aprovada pela autora original. Conclusão: a adaptação à cultura brasileira e a equivalência semântica foram concluídas satisfatoriamente, resultando numa versão com condições de ser submetida à análise de propriedades psicométricas e contribuir para identificação e manejo do fenômeno incivilidade nas instituições brasileiras de ensino de Enfermagem.
Autofocusing in off-axis digital Fresnel holography using S-th power weighted neighborhood correlation coefficient
Authors: Zhang Yupei , Song Xuhui , Qiu Peizhen 
Published: November 2023

Abstract
Accurately determining the focus plane of the reconstructed image is crucial for obtaining high-quality reconstructed images in the process of digital hologram reconstruction. In this paper, a focusing evaluation function based on S-th power weighted neighborhood correlation coefficient (SPWNCC) is proposed to realize automatic focusing of the reconstructed image in off-axis digital Fresnel holography. The Fresnel transform method is utilized as the off-axis digital holographic reconstruction algorithm. Both the numerical simulation and optical experiment results are given to verify the validity of the proposed autofocusing method. The obtained focusing curve can maintain good unimodality and noise immunity performance over a large search range (approximately 800 mm). The proposed SPWNCC based focusing evaluation function has a certain guiding significance on the automatic focusing of off axis digital holographic reconstructed images of long distance recorded objects.
STUDI KELAYAKAN RUANG TERBUKA HIJAU SEBAGAI FUNGSI INTRINSIK DAN EKSTRINSIK
Authors: WULANNINGRUM SINTIA DEWI 
Published: November 2023

RTH Grojogan Blora merupakan salah satu RTH yang berada di sempadan sungai. Dahulunya pada RTH terdapat kanal yang berfungsi untuk mencegah banjir, serta sebagai sarana transportasi air, serta memiliki fungsi ekologis sebagai pencegah longsor dan sebagai habitat flora dan fauna. Akan tetapi semakin berkembangnya zaman, fungsi RTH Grojogan juga mengalami perubahan terutama pada fungsi sosial dan ekonomi, seperti : adanya Pedagang Kaki Lima (PKL), terdapat area komunal dan terdapat spot memancing ikan. Kondisi pada RTH dan area komunal yang berada di tepian kanal, kurang nyaman , dimana kurangnya tempat sampah, penerangan dan akses masuk menuju area komunal terbatas, selain itu kursi taman serta area komunal yang kurang tertata. Sebagai salah satu RTH yang letaknya cukup strategis di pusat kota Blora, harusnya RTH Grojogan dapat menjadi magnet bagi masyarakat sekitar sebagai area rekreatif , dimana terdapat banjir kanal sebagai daya tarik visual. Oleh sebab itu, diperlukan studi Kelayakan RTH Grojogan terkait fungsi intrisnik dan ekstrinsik sehingga dapat memaksimalkan fungsi RTH , serta mengembalikan RTH Grojogan sebagai salah satu destinasi rekreatif di Kota Blora. Tujuan penelitian yaitu untuk menganalisa kelayakan RTH Grojogan berdasarkan fungsi intrinsik (ekologis), fungsi ekstrinsik (ekonomi, sosial dan budaya, serta estetika). Metode penelitian menggunakan kualitatif deskriptif dan kuantitatif . Hasil penelitian menunjukkan bahwa berdasarkan fungsi intrinsik (ekologi) RTH Grojogan telah mengalami penurunan fungsi ; sedangkan berdasarkan fungsi ekstrinsik secara sosial masih terdapat aktivitas masyarakat sekitar seperti memancing dan berinteraksi di sekitar RTH, secara budaya kurang terlihat dan secara ekonomi terdapat beberapa warung makanan yang berada di sepanjang RTH.
Studi Studi Elemen Arsitektur Islam pada Lengkungan Terpusat (Pointed Arch)
Authors: Putra Ghoustan 
Published: November 2023

Lengkungan (Arch) Ornamen adalah salah satu elemen yang muncul secara tipikal di bangunan Arsitektur Islam. Secara visual Lengkungan (Arch) merupakan fitur dekoratif penting yang ditransmisikan dari dekorasi arsitektural yang berbentuk seni dekorasi kedalam bangunan dan merupakan unsur tipologi dekoratif bagunan Arsitektur Islam. Pada periode awal Islam, umat Islam juga menerima pengaruh dari banyak peradaban, dan para ahli bangunan melakukan eksplorasi Arsitektur Islam yang saling mempengaruhi satu sama lain seperti Ottoman dan Renaisans. Lengkungan (arch) adalah elemen arsitektur penting sejak awal peradaban islam. Tipikal elemen Lengkungan bisa terlihat pada bangunan arsitektur islam baik untuk dinding, jendela, pintu, arcade hingga penutup atap seperti kubah, maupun minaret. lengkungan (Arch) juga seringkali menutupi bangunan dengan bentang besar maupun kecil. Lengkungan (Arch) bahkan muncul di peradaban Mesopotamia, Indus, Mesir, Babilonia, Yunani, dan Asyur. Bahkan Bangsa Romawi menerapkan teknik ini ke berbagai struktur bangunan. Penggunaan dan desainnya lengkungan selain digunakan untuk tujuan struktural dan fungsional juga untuk memenuhi tujuan dekoratif dan simbolik dari Arsitektur Islam itu sendiri. Sehingga Elemen Lengkungan kemudian digunakan di semua jenis bangunan Arsitektur islam namun paling umum berada di arcade dan kubah. Makalah ini membahas proses asimilasi lengkungan sebagai ornamen Arsitektur islam yang tipikal. Tulisan ini juga mengulas perkembangan dan pengaruh Elemen Lengkung pada bangunan Arsitektur Islam, mengulas histori, kekuatan struktur, dan keindahan Elemen Lengkung pada Arsitektur islam.
Analisis Tingkat Produktivitas dan Koefisien Tenaga Kerja Pada Pekerjaan Pelat Lantai
Authors: Abhimata Ryanmas 
Published: November 2023

Dalam proyek konstruksi, produktivitas tenaga kerja menjadi peran penting dalam keberhasilan suatu proyek. Tujuan penelitian ini adalah untuk mencari besaran nilai tingkat produktivitas dan koefisien tenaga kerja pada pekerjaan pelat lantai Hasil dari penelitian ini adalah besaran nilai tingkat produktivitas kelompok kerja di lapangan pada pekerjaan bekisting hari ke-1 sebesar 9,285 m²/Orang-jam. Pada pekerjaan Pembesian hari ke-1 sebesar 312,82 Kg/Orang-jam. Untuk pekerjaan pengecoran didapatkan sebesar 8,78 312,82 m³/Orang-jam. Dan pada pekerjaan pemasangan keramik hari ke-1 sebesar 19,616 m²/Orang-jam. Koefisien tenaga kerja didapat pada pekerjaan bekesting hari ke-1 koefisien mandor sebesar 0,17 OH, tukang sebesar 0,035 OH, dan pekerja 0,053 OH. Pada pekerjaan pembesian hari ke-1 koefisien mandor didapat sebesar 0,0004 OH. Pada pekerjaan pengecoran, koefisien mandor sebesar 0,017 OH dan koefisien pekerja didapat sebesar 0,053 OH. Sedangkan untuk pekerjaan pemasangan keramik pada hari ke-1 koefisien tukang didapat sebesar 0,02 OH dan pekerja sebesar 0,03 OH.
Kata kunci: Koefisien, Produktivitas, Tenaga Kerja
Decentralized Confidential Secure Certified Notification System Using Rejectable Identity Tokens and Identity based Cryptography
Authors: Imam Mohsin 
Published: November 2023

<p>The use of blockchain technology in various ecommerce applications, such as the establishment of certified notifications, has emerged. This particular service enables a user, assuming the role of a sender, to substantiate the transmission of specific data to a recipient. By leveraging blockchain technology, we can capitalize on its transparent and decentralized nature to ensure the genuineness and integrity of notifications. Our proposal is the deployment of Soulbound tokens (SBTs), which are unique NonFungible Tokens (NFTs) incapable of being transferred or traded to other users. Additionally, we enhance the ERC721 standard to encompass the functionality where the recipient has the option to decline a token, enabling selective acceptance of SBTs. By representing certified notifications as Rejectable SBTs (RejSBT), we establish a mechanism to monitor instances when a sender dispatches a notification and when the recipient acknowledges it, offering both non repudiation of origin (NRO) and reception (NRR) verifications. Once the recipient accepts the RejSBT signifying ownership of a notification, we employ Identitybased Cryptography to facilitate the owner's decryption of the confidential information encoded within the RejSBT. </p>
<p>The use of blockchain technology in various ecommerce applications, such as the establishment of certified notifications, has emerged. This particular service enables a user, assuming the role of a sender, to substantiate the transmission of specific data to a recipient. By leveraging blockchain technology, we can capitalize on its transparent and decentralized nature to ensure the genuineness and integrity of notifications. Our proposal is the deployment of Soulbound tokens (SBTs), which are unique NonFungible Tokens (NFTs) incapable of being transferred or traded to other users. Additionally, we enhance the ERC721 standard to encompass the functionality where the recipient has the option to decline a token, enabling selective acceptance of SBTs. By representing certified notifications as Rejectable SBTs (RejSBT), we establish a mechanism to monitor instances when a sender dispatches a notification and when the recipient acknowledges it, offering both non repudiation of origin (NRO) and reception (NRR) verifications. Once the recipient accepts the RejSBT signifying ownership of a notification, we employ Identitybased Cryptography to facilitate the owner's decryption of the confidential information encoded within the RejSBT.</p>