bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reaction mechanism of sodium with hydrogen fluoride in the formation of sodium fluoride and the adsorption of hydrogen fluoride on sodium fluoride monomer and tetramer
Authors: Yu Qinwei , Yang Jianming , Zhang Hai-Rong , Liang Peng-Yu , Gao Ge , Yuan Yongna , Dou Wei , Zhou Pan-Pan 
Published: October 2023

Abstract
To understand the detailed reaction mechanisms and sodium with hydrogen fluoride, theoretical investigations were carried out. The results suggest that the reaction between Na and HF leads to the formation sodium fluoride salt NaF and hydrogen gas. The detailed reaction mechanism of this process was discussed and illustrated. The resultant NaF can further form larger cluster like (NaF)4 tetramer, and NaF as well as (NaF)4 tetramer can adsorb HF molecule to form strong complex, and the adsorption mechanism was also uncovered.
Morphological and anatomical study of grasses Triticum aestivum L. and Phalaris minor Retz. a quick tool for assessing the impact of road side pollution
Authors: Singh Aditya , Supolia Damini , Akhter Raveena , Akhter Farida , Irshad Mahrukh , Bhat Mudasir Nazir , Kumar Ashok , Bhau Brijmohan Singh , Bhat Mudassir Ahmad 
Published: October 2023

Abstract

Plants grown close by roadside areas are exposed to variety of pollutants. Air pollution has an adverse effect on plants. Most air pollution comes from Automobiles. Automobiles have increased in number in tandem with population growth, as has pollution from automotive emissions. The first targets of these vehicular pollutants are roadside plants and roadway vegetation. Vehicle emissions contain a variety of contaminants that contribute to the worst types of pollution in the environment. Various contaminants from automobiles changed the properties of the vegetation that are exposed. One of the most obvious roadside plant is grass. This experiment shows how automobile emissions affect grasses anatomy and morphology. Experiments were conducted to investigate morphological as well as anatomical changes in leaves and culms of roadside grasses Triticum aestivum L. and Phalaris minor Retz.
To carry out the experiment, samples (Fresh leaves and Culms) were collected from polluted sites and non-polluted site acting as a control. For anatomical study leaves and stems were cut into sections and epidermal peeling was performed in the laboratory and changes were identified under the light microscopy. SEM analysis was also done. Results revealed the major anatomical and morphometric variations observed in both Triticum aestivumL. andPhalaris minor Retz. growing in polluted and non-polluted study sites. Reduction in morphometric parameters for both the specimens growing in polluted study sites indicated a negative effect of pollutants on the growth of these pooideae members. Not only that changes in the anatomy of the polluted site specimens, both in the culm and leaf anatomy was found. SEM images of the abaxial and adaxial surface of the leaves showed micro-morphological changes, with stomatal size and number showing a reduction in case of Triticum aestivumL. for the polluted site specimens while the size of stomata showed an increase in the case of Phalaris minor Retz. growing in polluted study sites. These results highlighted the importance of anatomical and morphological data to determine the responsiveness of roadside grasses to various environmental pollutants.
Study on the Impact of Refractive Anisometropia on Intermittent Exotropia, Stereopsis, and Amblyopia in Children
Authors: Qiao Shanli , Chen Jing , Zhang Jianfei , Sun Changfeng 
Published: October 2023

Abstract
Objective
To preliminarily explore the correlation between different types and degrees of refractive errors and strabismus, amblyopia, and stereopsis.
Methods
Data from 145 children with refractive errors and 30 children with normal vision were collected. Both groups of subjects underwent routine slit lamp and fundus examinations to exclude other organic eye diseases.
Results
① The incidence of strabismus in the refractive error group was higher than that in the normal control group (P < 0.05). ② Far-sightedness and mixed astigmatism were more prone to amblyopia than myopia and regular astigmatism. ③ When the refractive error was ≥ 1.00D, far stereopsis and random dot static 0-order stereopsis decreased, while near stereopsis Titmus showed no statistical difference.
Conclusion
Different types and degrees of refractive errors have different clinical features of strabismus and amblyopia. Among the three stereopsis examination methods, far stereopsis and random dot static 0-order stereopsis are more sensitive than near stereopsis and can better reflect damages to fine stereopsis.
Adjuvant Therapy Improves Survival in T1N1M0 Gastric Cancer Patients with Poorly Differentiated and Undifferentiated Types
Authors: Gu Mingyu , Xie Tianyu , Wen Minghai , Huang Zijie , Zhao Binghe , Li Shuo , Wu Di , Xu Ziyao , Wang Xinxin 
Published: October 2023

Abstract
Background
Whether adjuvant therapy has a survival benefit for all patients with T1N1M0 (Stage IB) gastric cancer (GC) remains controversial. This study attempted to confirm the value of adjuvant therapy in T1N1M0 GC patients with poorly differentiated and undifferentiated type.
Methods
Overall, 461 T1N1M0 GC patients with poorly differentiated and undifferentiated type following gastrectomy from 2004 to 2018 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score-matched (PSM) analysis was used to reduce bias. Overall survival was analyzed by Kaplan-Meier method and the log-rank test. Cox regression analyses were used to confirm the independent prognostic factors.
Results
Our study analyzed data from 461 patients in the Seer database who underwent postoperative treatment. Among them, 297 patients received adjuvant therapy. After PSM multivariate regression reveal that adjuvant therapy is associate with OS of the cohort (adjusted HR0.55; 95% CI: 0.38 ~ 0.77). The survival analysis presents that the 5-year OS was significantly higher in patients receiving chemotherapy (69.2% vs.51.5%, p < 0.001) and the 5-year CSS was higher in patients receiving chemotherapy (77.0% vs 61.1% p < 0.001).
Conclusion
In the population of patients with poorly differentiated and undifferentiated T1N1M0 gastric cancer, postoperative adjuvant therapy has shown potential survival benefits. However, further validation through randomized controlled trials (RCTs) is required to confirm this conclusion.
Unsupervised meta-analysis on chemical elements and atomic energy prediction: case study on periodic table
Authors: Belahcene Brahim 
Published: October 2023

Abstract

This paper presents an artificial classification and atomic energy correlation analysis of the periodic table. The choice of data mining method is due to its robustness, which can explore intrinsic or hidden relationships between chemical elements and their properties. The Mendeleev table is probably the earliest example of the data analysis technique in materials science. However, the classical periodic table represents the arrangement of chemical elements based on specific periodicities that have the problem of continuity of properties for some chemical elements. In this research, we used one of the unsupervised data mining methods (Principal Component Analysis) to investigate the chemical elements based on all the ready properties, some questions were raised before diving into this research. The main objective is to make a pseudo-classification of natural and synthetic chemical elements based on their physicochemical and energy-available properties. The results revealed the effectiveness of the data mining method in appreciating the relationships between the variables and properties that offer a new way of viewing a Mendeleev table. The last step of this work highlights the importance of predictive polynomial that allows the scientific community to make atomic total energy predictions for each natural periodic element, from helium to lawrencium.
Ecological environment quality analysis of Jiyuan City based on improved remote sensing ecological index
Authors: XIANG Zhonglin , ZHANG Shijie , DENG Libo 
Published: October 2023

Abstract
With the high-speed development of Jiyuan City, frequent human activities have caused increasing impacts on the ecological environment, so remote sensing monitoring of the ecological environment is of great significance for assessing the sustainability of regional ecosystems and human living environment. In this study, based on the Remote Sensing Ecological Index (RSEI), the Improved Remote Sensing Ecological Index (IRSEI) was created by choosing the Index of Building (IBI) and the Index of Bare Soil (SI) to represent the dryness indicators, respectively, and combined with the Principal Component Analysis (PCA) method to evaluate and analyse the quality of the ecological environment in Jiyuan City from 2002 to 2021. Conclusions were drawn: ① From 2002–2021, the five-year improved remote sensing eco-indexes of Jiyuan City were 0.50, 0.57, 0.59, 0.64, 0.62, respectively, with an overall increase in the ecological environment quality; ② During the study years, the area of grassland and water bodies in Jiyuan City increased continuously, with a total increase of 254.131 km2, and the area of bare soil and planted cultivated land decreased gradually, with a total decrease of 211.211 km2; ③ In terms of spatial distribution, the ecological environment quality in the northwestern mountainous area is the best, and the eastern urban area is relatively poor. Overall, the ecological environment management in the study area has achieved some success, but there is still much room for improvement.
Exploring the Therapeutic Mechanism of Jiangtang Sanhao Formula in Alleviating Insulin Resistance in Skeletal Muscle Cells: Involvement of AMPK/SIRT1/PGC-1α pathway？
Authors: Ye Zimengwei , Zhao Yi , Fang Xin , Xu Bingrui , Shi Hanfen , Li Runqi , Mo Fangfang , Zhang Dongwei , Zhao Dandan , Gao Sihua 
Published: October 2023

Abstract
Insulin resistance (IR) in skeletal muscle is a well-documented pathologic characteristic in the development of type 2 diabetes mellitus (T2DM), with GLUT4 being a key protein involved in this process. Jiangtang Sanhao formula, (JTSHF), a proven effective prescription for treating T2DM in clinic, has been shown to have a beneficial effect on alleviation of skeletal muscle IR. However, the underlying mechanism still need to be explored. Herein, we investigated the potential benefits and mechanism of JTSHF-containing serum in combating IR induced by palmitate in C2C12 skeletal muscle cells. The results demonstrated that JTSHF-containing serum significantly enhanced glucose consumption and uptake in IR-C2C12 cells at noncytotoxic concentration. Moreover, the JTSHF-containing serum reduced the malondialdehyde level and increase superoxide dismutase activity. Further investigations showed the function of JTSHF-containing serum in up-regulating the expression of key factors involved in glucose transport and metabolism, including GLUT4, phosphorylated AMPKα, SIRT1, PGC-1α, PPARα, PPARγ, and UCP3, as well as GLUT4 translocation. Notably, these positive effects were substantially diminished when we used an AMPK inhibitor, named Compound C, suggesting that AMPK/SIRT1/PGC-1α signaling pathway may be involved in JTSHF’s ability to rescue palmitate-induced reductions in GLUT4 expression and translocation in IR-C2C12 cells. In summary, our study provides evidence that JTSHF may effectively regulate GLUT4 and counteracte IR in skeletal muscle cells, and it highlights the potential involvement of the AMPK/SIRT1/PGC-1α signaling pathway in mediating these beneficial effects.
Ranibizumab for the treatment of Age-Related Macular Degeneration related research hotspot and dynamic
Authors: Xiaodong Li , Xuewei Qin , Dandan Wu , Yi Yang , Zhilin Li 
Published: October 2023

Abstract

Objective:Bibliometric analysis in the research area of Ranibizumab and Age-Related Macular Degeneration(AMD) was conducted to describe the current trends in international research dynamics in the field and to present a visual representation of the research hotspots and difficulties in ophthalmic drugs in the last fifteen years.Method:In this cross-sectional study, bibliometrics analyzed data retrieved and extracted from the Web using the Science Core Collection (WOSCC) database to analyze the evolution and thematic trends in the delivery of studies from January 1, 2008, to September 2, 2023, for Ranibizumab and AMD studies. A total of 2691 articles on the field were assessed for specific characteristics such as year of publication, journal, author, institution, country/region, citation and keywords. Co-authorship analysis, co-occurrence analysis, co-citation analysis, and network visualization were constructed using VOSviewer. Bibliometrics identified a number of important sub-themes for further discussion and review of characterization.Results:From 2008 to 2023, the cumulative number of articles published globally increased from 1 to 2,691, with the highest number of articles published in 2020 (255 papers). RETINA THE JOURNAL OF RETINAL AND VITREOUS DISEASES published the most manuscripts (285 papers) and was cited (6,496 citations), followed by OPHTHALMOLOGY (193 papers) and GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (163 papers). OPHTHALMOLOGY was the most cited (20,865 citations), with the United States (786 papers, 38,014 citations), univ sydney (98 papers, 5,245 citations), and kim, jong woo (56 papers, 550 citations) being the most productive and influential institutions, countries, and authors, respectively.Co-occurring clusters: the top 100 keywords analyzed form 5 clusters:Marking the emerging frontiers in the field of ranibizumab and AMD. Further discussion of the 5 clusters of research is to assist the researcher in determining the scope of the research topic and planning the direction of the research.Conclusion:The number of publications and citations of research related to Ranibizumab and AMD has been increasing over the last two decades in many countries, institutions and authors. This study reveals the current trends, global collaboration patterns, basic knowledge, research hotspots and developmental trends in Ranibizumab associated with AMD research. New solutions of Ranibizumab for AMD such as shorter number of injections, prolonged drug efficacy and safety have been the major themes in the last 15 years.
Comparing the Use of Washingtonia Filifera Seed Extract in Various Solvents for ZnO Nanoparticle Synthesis, Characterization, and its Potential Anti- inflammatory and Biological Applications
Authors: Jalil Parwin Jalal , Mhamedsharif Renjbar M. , Shnawa Bushra Hussain , Hamad Samir Mustafa , Mohammed Ahmed Salih , Aspoukeh Peyman K. 
Published: October 2023

Abstract
The present study involves the green synthesis of zinc oxide nanoparticles ZnO NPs using three different solvents for plant extract of ethanol (EtOH), methanol (MeOH), and double distilled water (ddH2O) in a method that is rapid, cost-effective, and environmentally friendly. The novelty of this study was creating ZnO NPs from Washingtonia filifera plant seed extract. Green fabricated ZnO NPs were characterized via UV–Vis spectroscopy, Fourier transform infrared (FT-IR), energy-dispersive spectroscopy (EDX), and X-ray diffraction (XRD). SEM data showed the efficacy of palm seed extract metabolites in fabricating spherical shape of ZnONPs, with an avarage size of 50, 71.6, and 81.6 nm for ddH2O, EtOH, and MeOH Zn ONPs, respectively. FT-IR analysis showed varied absorption peaks related to fuctional group of plant extract and nanoparticle formation. Moreover, data analysis revealed that the antimicrobial activity against pathogenic Gram-positive and Gram-negative bacteria and fungi was dose-dependent and exhibited variable inhibition zone values. In comparison to the plant extract alone, which provides minimum antimicrobial activity, the ZnO NPs prepared from this plant inhibit bacterial activity more efficiently. MeOH-ZnO NPs formed a maximum clear zones, 23.5 ± 0.3, 26.0 ± 0.3, and 19.8 ± 0.3 mm, at highest concentrations of 500 µg/ml against S. aureus, P. aeruginosa, E. coli, respectively. EtOH-ZnO NPs exhibit 82.2, 82.2, and 67.2% of mycelial inhibition after 6 days of treatment with ZnO NPs for A. niger, A. fumigatus and S. apiospermum, respectively. Also, biosynthesized ZnO NPs showed a potent anti-inflammatory activity of were dose-dependent. The present anti-bacterial activities were increased as the NPs concentration increased. The W. filifera-mediated ZnO NPs showed strong antimicrobial activity against clinical pathogens compared to standard drugs. This suggests that plant-based synthesis of NPs can be an excellent strategy for developing versatile and eco-friendly biomedical products.
Clinical application of middle descending colon-double lumen ostomy with distal stoma narrowing in the treatment of anorectal malformation.
Authors: Huang Guoxian , Li Wenni , Ma Lili , Lei Xin , Lin Xiangde , Chen Yuandong , Xu Bo 
Published: October 2023

Abstract
Background
Anorectal malformations (ARMs) are the most common con- genital anomaly of the digestive tract. And colostomy should be performed as the first-stage procedure in neonates diagnosed with intermediate- or high-type ARMs. However, the most classic Pe˜na’s colostomy still has some disadvantages. We aimed to explore the effectiveness of middle descending colon-double lumen ostomy (MDCDLO) in the treatment of high and intermediate types of anorectal malformations.
Methods
We retrospectively reviewed the data of patients who underwent MDCDLO for high or intermediate types of ARMs between June 2016 and December 2021 in our hospital. The basic characteristics were recorded. All patients were followed up monthly to determine if any complication happen.
Results
There were 17 boys and 6 girls diagnosed with high or intermediate types of ARMs in our hospital between June 2016 and December 2021. All 23 patients were cured without complications such as abdominal incision infection, stoma stenosis, incisional hernia, and urinary tract infection in the postoperative follow-up time of 6 months to 6 years except one case of proximal intestinal prolapse was restored under anesthesia.
Conclusion
MDCDLO offers the advantages of simplicity, efficiency, safety, mild trauma, and small scarring in the treatment of high and intermediate types of anorectal malformations.
Privacy Preserving Heart Rate Estimation from ECG and PPG Signals for Application in Remote Healthcare
Authors: Islam Tasnim Nishat , Imtiaz Hafiz 
Published: October 2023

Abstract

In this work, we develop a computationally-light and robust neural network model for estimating heart rate for applications in remote healthcare systems. More specifically, we develop a model that can be trained on consumer-grade graphics processing units (GPUs) and can be deployed on edge devices for swift inference. To this end, we propose a hybrid model based on convolutional neural network (CNN) and bidirectional long short-term memory (BiLSTM) architectures for estimating heart rate from ECG and PPG signals. Considering the sensitive nature of the ECG signals, we ensure a formal privacy guarantee – differential privacy, for the model training. We perform a tight accounting of the overall privacy budget of our training algorithm using the Rényi Differential Privacy technique. We demonstrate that our model outperforms state-of-the-art networks on a benchmark dataset for both ECG and PPG signals, despite having much smaller number of trainable parameters, and consequently much smaller training and inference times. Additionally, our CNN-BiLSTM architecture can provide excellent heart rate estimation performance even under strict privacy constraints. Last but not the least, we develop a prototype Arduino-based data collection system that is low-cost and efficient, and therefore, useful for providing access to modern healthcare services to the people living in remote areas.
Progression free survival of myeloma patients who become IFE-negative correlates with the detection of residual monoclonal free light chain (FLC) by mass spectrometry
Authors: Giles Hannah , Drayson Mark , Kishore Bhuvan , Pawlyn Charlotte , Kaiser Martin , Cook Gordon , de Tute Ruth , Owen Roger , Cairns David , Menzies Tom , Davies Faith , Morgan Gareth , Pratt Guy , Jackson Graham 
Published: October 2023

Abstract
Deeper responses are associated with improved survival in patients being treated for myeloma. However, the sensitivity of the current blood-based assays is limited. Historical studies suggested that normalisation of the serum free light chain (FLC) ratio in patients who were negative by immunofixation electrophoresis (IFE) was associated with improved outcomes. However, recently this has been called into question. Mass spectrometry (MS)-based FLC assessments may offer a superior methodology for the detection of monoclonal FLC due to greater sensitivity. To test this hypothesis, all available samples from patients who were IFE negative after treatment with carfilzomib and lenalidomide-based induction and autologous stem cell transplantation (ASCT) in the Myeloma XI trial underwent FLC-MS testing. FLC-MS response assessments from post-induction, day + 100 post-ASCT and six months post-maintenance randomisation were compared to serum FLC assay results. Almost 40% of patients had discordant results and 28.7% of patients with a normal FLC ratio had residual monoclonal FLC detectable by FLC-MS. FLC-MS positivity was associated with reduced progression-free survival (PFS) but an abnormal FLC ratio was not. This study demonstrates that FLC-MS provides a superior methodology for the detection of residual monoclonal FLC with FLC-MS positivity identifying IFE-negative patients who are at higher risk of early progression.
A Process Reference Model for Blockchain dApp Development for the Health Domain
Authors: Baysal Merve Vildan , Özcan-Top Özden , Can Aysu Betin 
Published: October 2023

Abstract

Blockchain technology has gained significant attention across various fields in recent years, including its applications in the health domain. Examples of such applications are medicine supply chain management, health record management, clinical trial management, and remote patient monitoring. Although the health domain is highly regulated, there is currently a lack of comprehensive studies presenting the essential blockchain processes, practices, and guides for development teams for ensuring health regulations. To address this gap, this study proposes the Blockchain Health dApp Process Reference Model (BDRM) specifically for developing blockchain dApps in the health domain. The BDRM was developed through a systematic review of formal and gray literature, considering expert opinions to specify the processes and practices, and integrating IEC 82304, IEC 62304, ISO 14971, and ISO/IEC 12207 standards’ requirements to make the reference model regulatory compliant. The model consists of 15 processes and 68 practices associated with these processes. The study also describes the application of design science research during the model's development. The proposed BDRM can benefit developers, researchers, and decision-makers by providing a useful resource for the development of blockchain applications in the health domain.