bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable Hydrogel-Based Combination Therapy for Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Trials
Authors: Gao Han , Liu Song , Qin Shanshan , Yang Jiali , Yue Tian , Ye Bengui , Tang Yue , Feng Jie , Hou Jun , Danzeng dunzhu 
Published: October 2023

Abstract
Introduction:
This study evaluates the efficacy of a combined regimen based on injectable hydrogels for the treatment of experimental myocardial infarction.
Patient concerns:
Myocardial infarction is an acute illness associated with a decline in quality of life and increased mortality. Experimental myocardial infarction models can facilitate disease research for developing therapies that effectively manage disease progression and promote tissue repair.
Diagnosis:
An experimental myocardial infarction animal model was established using the ligation method of the anterior descending branch of the left coronary artery (LAD).
Interventions:
The efficacy of combining hydrogels with various therapies for intramyocardial injection was assessed to evaluate the functional and morphological improvements in the post-infarction heart achieved through the combined hydrogel regimen.
Outcomes:
The literature review spanned PubMed, Web of Science, Scopus, and Cochrane databases. A total of 83 papers were included in the meta-analysis according to the inclusion and exclusion criteria. When analyzing a murine small animal model, the combination therapy group using hydrogel showed a significant improvement in the primary outcome of left ventricular ejection fraction, with an overall effect size of 11.68 (95% confidence interval (CI): 10.24,13.12) compared to the group receiving hydrogel injection alone. The overall effect size for short-axis shortening was 6.25 (95% CI: 5.98,6.52). Subgroup analysis suggested that the source of hydrogel had a minor impact on the treatment outcome.
Conclusion
The present study demonstrated that combining hydrogel with other therapies effectively treated myocardial infarction, improving heart function and morphology. More research and clinical trials should be conducted using large animal models for further study and validation.
Discovering New Color Developers for Thermochromic Microcapsules Using a Variational Autoencoder
Authors: Kim Taehoon , Guk Hyein , Yun Jae Hoon , Kim Daejin , Kim Jonghwa , Choi Seung-Hoon , Chung Dong Hyen 
Published: October 2023

Abstract
In our pursuit of safer alternatives to Bisphenol A (BPA) for use as color developers in thermochromic microcapsules, our goal was to mitigate endocrine disruption without compromising the properties of BPA-based microcapsules. We began by scrutinizing the effect of 11 BPA derivatives on temperatures at which microcapsules change color (color-changing temperatures). The color-changing temperatures were determined using sigmoid fitting of the color density versus temperature plot, leading to four regression models connecting these temperatures to the color developer structures. To assess endocrine-disrupting potential and toxicity, we adopted machine learning models from the Open QSAR Application (OPERA). Concurrently, using atom-wise tokenization, we trained a variational autoencoder on SMILES data of drug-like molecules. With this approach, we have achieved a six-fold speed increase in training with 20% fewer parameters than conventional character-wise tokenization. After transfer learning with potential color developer data, this model generated new SMILES data, which were subsequently evaluated for their properties. In the end, we have obtained a compilation of SMILES predicted to be effective and safer replacements for BPA.
The Dissolution of Waste Zinc Filter Cake by Taguchi Method and Sulfide Precipitation of Cadmium and Nickel
Authors: Kafash Yasaman , Raygan shahram , Pourabdoli Mehdi , Lashgari Vahid A. 
Published: October 2023

Abstract
During the hydrometallurgical production of Zinc, filter cake obtained from the purification process of Zinc sulfate solution can be considered one of the essential secondary resources of Cadmium. In the current research, using the Taguchi method, the effects of various parameters such as dissolution reaction time (10–40 min), temperature (25–80°C), sulfuric acid concentration (2–11 vol.%) and particle size distribution (four size fractions) under liquid/solid ratio of 10 and stirring speed of 600 rpm on leaching of Cd dissolution from Cd-Ni filter cake were evaluated and optimized. The experimental plan was designed using an orthogonal array, L16 (44), which denotes four parameters with four levels. The optimum dissolution conditions proposed by the Design Expert software were a reaction time of 40 min, temperature of 80°C, sulfuric acid concentration of 8 vol. %, and particle size distribution of -75 + 53 µm with predicted dissolution content of Cd equals to 93.15% by the software. In the optimum condition, 95.2% of the Cd content was leached during the verifying test. According to the results, reaction time, particle size distribution, acid concentration, and temperature are the most affecting parameters on Cd dissolution, respectively. Separation of Ni and Cd present in the solution after dissolution using sodium sulfate precipitation in the pH range of 1 to 5 was studied, and the results show that at pH = 3, maximum separation of Ni and Cd (with weight ratio of Cd to Ni in the precipitates equals to 46.2) was achieved.
Mandibular response after rapid maxillary expansion in mixed dentition children with different vertical growing patterns: A retrospective study
Authors: YANG GANG , Xiang Xianhua , Tong Xianqin , Li Yuanyuan , Liu Yuehua 
Published: October 2023

Abstract
Introduction:
This study aimed to evaluate the mandibular development induced by rapid maxillary expansion (RME) therapy in mixed dentition patients with different vertical growth patterns.
Methods
This retrospective design incorporated two cohorts: a control group consisting of pediatric subjects presenting individualized malocclusion, and an experimental group subjected to RME therapy. A total of 60 subjects were included in this retrospective study, 37 in the RME group (17 males and 20 females) and 23 in the control group (13 males and 10 females). Subsequent to quantifying 22 pertinent morphometric parameters via Dolphin Imaging software, the participants were classified into either high-angle or even-angle subgroups based on MP-FH value. Changes in the groups during the observation period were calculated, compared, and statistically analyzed with a t-test.
Results
Compared to the control group, both ANB angle and overjet tended to decrease after treatment in the RME group (P < 0.05), and none of the vertical correlations (MP-SN, FH-MP, N-me, S-Go, S-Go/N-Me and Overbite) were statistically different (P > 0.05). Within the even-angle experimental subgroup, the ANB angle, Wits appraisal, and overjet markedly decreased when contrasted with their even-angle control counterparts (P < 0.05). Notably, a substantive decrease in overjet was solely observable in the sagittal dimension among the high-angle expansion subgroup when compared to the high-angle control subgroup (P < 0.05). In the vertical dimension, neither the even-angle nor high-angle subgroups exhibited any statistically significant disparity relative to their respective control cohorts (P > 0.05).
Conclusions
The results of current investigation substantiate that RME therapy promoted sagittal growth of the mandible in subjects with even-angle vertical growth patterns through long-term observation. Whereas no analogous tendency was discerned in subjects manifesting high-angle vertical growth patterns. In addition, the mandibular plane angle did not increase after RME in children with high angles, thereby negating the hypothesis that high angles serve as a contraindication for RME.
Swin-EchoNet: Deep Learning-based Two-Chamber Segmentation of 2D Echocardiography using Swin Transformer
Authors: A Shamla Beevi , Nagarkoti Amit , Kalady Saidalavi , Chackola Jenu James Chackola 
Published: October 2023

Abstract
The initial crucial stage in recognizing heart-related problems involves making a precise diagnosis. Live heart images can be obtained through techniques such as MRI, CT scan, and Echocardiography. Determining significant cardiac parameters for disease diagnosis, such as systolic and diastolic volumes, ejection fraction, and left atrium (LA), requires accurate segmentation of the left ventricle in echocardiography images. However, automated segmentation of these images is a complex and challenging task. Therefore, there is a requirement for a fully automatic method that can accurately segment cardiac images and save time. We utilized our proposed model Swin-echonet architecture for accurate left ventricle segmentation in echocardio-graphy images. Our method has been successfully tested on two separate datasets, namely the CAMUS dataset with 1800 echocardiographic images and data from a hospital with 1550 echo images. On the CAMUS dataset, we achieved a mean dice coefficient of 0.951±0.2271. Additionally, our method produced a mean IoU of 0.7263 and a mean Dice coefficient of 0.9738 on the second dataset. The obtained results demonstrate the efficiency of our method across diverse datasets, indicating its potential to assist medical professionals in the detection and treatment of cardiac problems.
Precise planning based on 3D-printed dry-laboratory models can reduce perioperative complications of laparoscopic surgery for complex hepatobiliary diseases: A preoperative cohort study
Authors: Yao Wei-Feng , Huang Xiao-Kun , Fu Tian-Wei , Jin Lei , Du Cheng-Fei , Gao Zhen-Yu , Wang Kai-Di , Dai Mu-Gen , Liu Si-Yu , Liu Jun-Wei , Zhang Cheng-Wu , Liang Lei , Huang Dong-Sheng 
Published: October 2023

Abstract

Background & Aims:
Complications after laparoscopic liver resection (LLR) are important factors affecting the prognosis of patients, especially for complex hepatobiliary diseases. The present study aimed to evaluate the value of a three-dimensional (3D) printed dry-laboratory model in the precise planning of LLR for complex hepatobiliary diseases.
Methods
Patients with complex hepatobiliary diseases who underwent LLR were preoperatively enrolled, and divided into two groups according to whether using a 3D-printed dry-laboratory model (3D group vs. control group). The two groups were compared regarding the operative time, intraoperative bleeding volume, and postoperative complications. Multivariable logistic analysis was performed to determine the risk factors of postoperative complications.
Results
Sixty-two patients with complex hepatobiliary diseases underwent the precise planning of LLR. Among them, thirty-one patients acquired the guidance of a 3D-printed dry-laboratory model, and others were only guided by traditional enhanced CT or MRI. The results showed no significant differences between the two groups in baseline characters. However, compared to the control group, the 3D group had a lower incidence of intraoperative blood loss, as well as postoperative 30-day and major complications, especially bile leakage (all P < 0.05). Multivariable analysis showed the 3D model was an independent protective factor in decreasing postoperative complications. Subgroup analysis also showed that a 3D model could decrease postoperative complications, especially for bile leakage in patients with intrahepatic cholelithiasis.
Conclusion
The 3D-printed models can help reduce postoperative complications. The 3D-printed models should be recommended for patients with complex hepatobiliary diseases undergoing precise planning LLR.
Effects of parenting styles on social functioning impairments in Chinese children and adolescents with ADHD mediated by stressful life events
Authors: wu yuanzhen , luo jie , Zheng Qingyi , Huang Huanhuan , Zhang Zhixia , zheng Yi , He Fan , Qi Yanjie 
Published: October 2023

Abstract
Background: To explore the direct effect of parenting styles on social functioning impairmentin Chinese children and adolescents with ADHD, and the indirect effect through stressful life events.
Methods: This study included 1,870 participants (aged 6-16 years) enrolled from April to July 2014 as part of the Epidemiological Study of Child and Adolescent Psychiatric Disorders. Egna Minnen av Betraffande Uppfostran (EMBU), Social Function Rating Scale (SFRS) and Adolescent Life Events Scale (ASLEC) were used to assess parenting styles, social function impairment and stressful life events respectively.
Results: Parental emotional warmth reduces the occurrence of stressful life events and impairment of social functioning (p<0.01). Linear regression model indicated that father emotional warmth, severe punishment, mother severe punishment and stressful life events significantly predict social function impairment (p<0.05). Mediation analysis indicated that stressful life events mediate the relationship between parenting styles and social function impairment.
Conclusions: Different parental rearing styles and life events were found to impact social function impairment among child with ADHD. The way to improve the prognosis of children with ADHD should be to enhance parenting education, as supportive parenting styles predict fewer perceived experience of stressful life events and reduced impairment of social functioning in children with ADHD.
Comparison of efficacy and safety between da Vinci robot-assisted surgery and thoracoscopic surgery in the treatment of mediastinal tumors: A systematic review and meta-analysis
Authors: Dang Jiying , Wu Zhengqi , Sun Shize , Shan Yidong , Zhang Huiling 
Published: October 2023

Abstract
Objective
Systematic evaluation of the efficacy and safety of da Vinci robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) in the treatment of mediastinal tumors.
Methods
Computer retrieval of PubMed, Embase, The Cochrane Library, and Web of Science databases for literature comparing the clinical effects of RATS and VATS in treating mediastinal tumors, with the retrieval time limit from the establishment of the database to September 2023. Two researchers independently screened the literature and extracted data. The Newcastle-Ottawa Scale was used to assess the quality of the literature, and RevMan 5.4 was used for Meta-analysis.
Results
A total of 19 articles were included, with a total of 3517 patients. The results of the Meta-analysis showed that the RATS group had less intraoperative bleeding [MD=-5.20, 95%CI (-9.28, -1.12), P = 0.01], lower rate of conversion to thoracotomy [OR = 0.41, 95%CI (0.23, 0.72), P = 0.002], lower rate of total postoperative complications [OR = 0.57, 95%CI (0.34, 0.95), P = 0.03], shorter postoperative drainage time [MD=-0.72, 95%CI (-1.13, -0.32), P = 0.0004], and shorter postoperative hospital stay [MD=-0.90, 95%CI (-1.16, -0.65), P < 0.001], in comparison with the VATS group. There was insignificant difference between the two groups in terms of tumor size [MD=-0.02, 95%CI (-0.33, 0.30), P = 0.91] and operation time [MD = 0.17, 95%CI (-7.61, 7.94), P = 0.97]. However, in regards of hospitalization costs [MD = 2634.75, 95%CI (991.62, 4277.88), P = 0.002], the RATS group was more expensive than the VATS group.
Conclusion
Robot-assisted mediastinal tumor resection surgery has more advantages in terms of intraoperative bleeding, conversion to thoracotomy rate, total postoperative complication rate, postoperative drainage time, and postoperative hospital stay, in comparison with thoracoscopic-assisted mediastinal tumor resection surgery. There is insignificant difference in tumor size and operation time between the two surgeries. However, robot-assisted mediastinal tumor resection surgery increases hospitalization costs.
Recurrent models of orientation selectivity enable robust early-vision processing in mixed-signal neuromorphic hardware
Authors: Sabatini Silvio P. , Baruzzi Valentina , Indiveri Giacomo 
Published: October 2023

Abstract

Mixed signal analog/digital neuromorphic circuits represent an ideal medium for reproducing the dynamics of biological neural systems in real-time with bio-physically realistic dynamics.
However, similar to their biological counterparts, these circuits have limited resolution and are affected by a high degree of variability.
Considering this, we developed a recurrent spiking neural network that implements a faithful model of the retinocortical visual pathway to reliably produce Gabor-like receptive fields tuned to visual stimuli with specific orientation and spatial frequency properties.
Specifically, we developed a neuromorphic visual system comprising a Dynamic Vision Sensor that emulates the transient pathway of real retinas and a mixed-signal Dynamic Neuromorphic Asynchronous Processor with adaptive exponential integrate-and-fire neurons and dynamic synapses and mapped the recurrent network model on it to produces the desired orientation and spatial frequency tuning responses.
Compared to alternative feed-forward schemes, the model developed gives rise to robust highly structured Gabor-like receptive fields of any phase symmetry, optimizing the hardware resources available in terms of synaptic connections.
We present experimental results using both synthetic and natural images validating the model with its hardware implementations.
Unraveling the Friction and Wear Characteristics of the High Hardness, Low Young's Modulus 60NiTi Alloy: A Synergistic FEM Simulation and Experimental Study
Authors: Yin Ziming , Zheng Lijing , Li Jing , Li Bo , Zhang Hu 
Published: October 2023

Abstract
A finite element model of 60NiTi plate and Si3N4 ball (wear system) was established based on the discrete modified Archard model. The CSS-42L bearing steel with high Young's modulus was chosen as contrast material. The stress distribution, depth of wear marks, and wear rate were quantitatively analyzed to evaluate the feasibility of low Young's modulus of 60NiTi as bearing material. The FEM results revealed that the subsurface stress distribution exhibited a trend of first rising and then falling along the depth direction, and the peak stress position of 60NiTi alloy was found at about 100µm from the surface under a 30N load. The peak stress was reduced by 22.7% compared with the CSS-42L bearing steel at a 30N load, which demonstrating the superior load resistance of 60NiTi alloy. After undergoing friction and wear, the surface hardness of 60NiTi alloy was higher than the original hardness. Additionally, a significant increase in subsurface hardness was also observed due to same processes. Furthermore, the distribution and peak position of hardness along the depth direction was similar to the stress obtained from FEM, which indirectly confirmed the reliability of FEM simulation.
Characterization of Salmonella spp. in a tertiary hospital in 2019-2021 in Nanjing, China: Focusing on the clonal dissemination of Salmonella Enteritidis ST11
Authors: Hua Miao-Miao , Li Jia , Zheng Jie , Wang Jing-Jing , Zhang Yan , Zhang Zhi-Feng , Cao Xiao-Li , Shen Han 
Published: October 2023

Abstract
Background To characterize clinical Salmonella spp. by whole genome sequencing (WGS)
Methods Totally, 38 clinical Salmonella enterica isolates were subjected to antimicrobial susceptibility testing (AST), slide agglutination tests, and multi-locus sequence typing (MLST). Whole-genome sequencing (WGS) was performed to analyze the serovars, antibiotic-resistance genes (ARGs), virulence factors (VFs), sequence types (STs), and plasmid replicons. A phylogenetic tree was constructed to investigate the underlying genetic relationships.
Results Thirteen serovars were identified, with Enteritidis (n = 19, 50.0%) being the most common, followed by Typhimurium (n = 4, 10.5%). High resistance against ampicillin (n = 27, 71.1%) and ampicillin/sulbactam (n = 24, 63.2%) was observed, and seven (18.4%) isolates were multidrug resistant (MDR). In total, 36 types of ARGs were detected, among which blaTEM-1B (n = 25, 65.8%) was the most frequent, and mutations in gyrA and/or parC were identified in 34 (89.5%) strains. Notably, 333 different VFs were detected, of which 177 were shared by all the strains. Fifteen distinct STs were identified, with ST11 being the most predominant, and a close genetic relationship between them can be observed in the phylogenetic tree. Ten different plasmid replicons were found, with the dominant ones being IncFIB(S), IncFII(S), and IncX1 in S. Enteritidis (94.7%).
Conclusions More Salmonella serovars have been identified with the development of new molecular detection techniques. In addition to the high resistance and potential pathogenicity displayed by Salmonella spp., the clonal dissemination of S. Enteritidis ST11 highlights the urgent need to implement infection and control measures.
The Effect of Immunonutrition and Chemotherapy-Induced Neutropenia in Advanced Gastrointestinal Cancer Receiving Palliative Chemotherapy, A Pilot Randomized Controlled Trial
Authors: Injong Rungprakai , Somlaw Nicha , Rattananupong Thanapoom , Teeyapun Nattaya , Sriuranp Virote , Tanasanvimol Suebpong , Parinyanitikul Napa 
Published: October 2023

Abstract
Background: Malnutrition affects individual health status and impacts the response to chemotherapy in cancer patients. Furthermore, chemotherapy may worsen the nutritional status in these patients and vice versa. Therefore, oral nutrition supplements (ONS), either standard or special formula, have been recommended by several guidelines in these settings. Immunonutrition formulas theoretically provide a better anticachectic, anti-inflammatory and anti-tumor effect to a regular diet or standard formula.
Objective: To compare the effect of ONS with immunonutrients and standard ONS on grade II-IV neutropenia in gastrointestinal (GI) cancer that has received palliative chemotherapy.
Methods: We conducted a single-center, double-blind, prospective controlled trial in patients with advanced GI cancer who received palliative chemotherapy. Patients were randomized into two groups, ONS with immunonutrients (ONS-IM) and standard ONS formula (ONS-SF) with 500 kcal/day. The primary endpoint was the incidence of neutropenia grade II-IV. Furthermore, body weight, body composition, PG-SGA (Patient-Generated Subjective Global Assessment) scores, dietary intake, inflammatory parameters, and treatment toxicities were evaluated at baseline and 12 weeks after chemotherapy between two groups.
Results: A total of 50 patients were included (24 vs 26 in the ONS-IM vs. the ONS-SF, respectively). All patients were diagnosed with colorectal cancer, 24(48%) were men, with a mean age of 65.8 years (IQR 34-84). PG-SGA ≥9 was 60%, 46% had ≥ 2 organ metastases and 54% received first-line chemotherapy. There were no statistical differences in the baseline characteristics between the two groups. Neutropenia grade II-IV occurred less frequently in the ONS-IM group compared to the ONS-SF group (16.7% vs 42.3%, P =0.067), especially in subgroup of patients who received either ONS-IM or ONS-SF more than 70% (14.3% vs 45.8%, P=0.028). The mean differences in the PG-SGA score were significantly better in the ONS-IM compared to ONS-SF group (6.7; 95%CI:5.35,8.14 vs 4.72; 95%CI:3.09,6.35, P=0.05). Body fat mass and the percentage of CD3 count were improved significantly in the ONS-IM group compared to the ONS-SF group. There was no difference in other inflammatory markers between the two groups.
Conclusions: Patients who were supplemented with immunonutrition demonstrated a decrease in grade II-IV neutropenia, improved PG-SGA scores, body fat mass and the percentage of CD3 counts.