bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference-Making Pathways to Frailty Through Social Factors: A Configurational Analysis
Authors: Pollak Chava , Verghese Joe , Blumen Helena M 
Published: December 2023

Abstract

Background and Objectives
Social disconnection is highly prevalent in older adults and is associated with frailty. It is unclear which aspects of social disconnection are most associated with frailty, which ones are difference-making, and which combination of social factors are directly linked to frailty.

Research Design and Methods
We conducted a secondary coincidence analysis (CNA) of 1,071 older adults from the Rush Memory and Aging Project (mean age 79.3 ± 7.1; 75.8% female) to identify combinations of social factors that are difference-making for frailty. We included 7 demographic (e.g., age, sex, socioeconomic status) and structural (e.g., social network), functional (e.g., social support, social activity), and quality (e.g., loneliness) aspects of social connection. An established cut score of 0.2 on a frailty index was used to define frailty as the outcome.

Results
CNA produced 46 solution models for the presence of frailty in the data set. The top-scoring model was underfit, leaving a final complex solution path for frailty with the highest fit-robustness score that met the fit parameter cutoffs. We found that the combination of loneliness, low social activity, and older age was present 82% of the time when frailty was present.

Discussion and Implications
The combination of loneliness, social activity, and old age is difference-making for frailty, and supports the inclusion of social factors in frailty prevention and intervention. Further research is needed in diverse data sets to better understand the interrelationships between the 3 aspects of social connection and frailty.
News media framing of food poverty and insecurity in high-income countries: a rapid review
Authors: Kerins Claire , Furey Sinéad , Kerrigan Páraic , McCartan Aodheen , Kelly Colette , Vaughan Elena 
Published: December 2023

Abstract
Food poverty and insecurity have become a public health emergency in many high-income countries. News media coverage can shape public and political views towards such issues. This rapid review synthesizes the evidence on how food poverty and insecurity are represented in the news media. Peer-reviewed publications were accessed through three electronic databases, with reference lists of all included studies screened. Primary research studies conducted in high-income countries and published in English since 1995 were included, with no restrictions on study methods. A combination of deductive coding to Entman’s framing theory and inductive analysis was used. Ten studies, mostly rated as low quality, were included in the review. Newspapers were the only type of news media examined. The findings showed a largely absent nuanced understanding of food poverty and insecurity, with the problem often defined by food bank use and the consequences mainly focused on physical health. The causes were mostly attributed to structural factors, with the solutions largely focused on charitable food aid. The discourse of recipient (un)deservingness of food aid was evident. Articles often contained views from government officials and charities, with individuals’ experiences of food poverty and insecurity largely absent. The findings of this review highlight that a major shift in print media discourse on food poverty and insecurity is required. More balanced and critical news reporting is required to present a more realistic picture of food poverty and insecurity, including its multi-dimensional nature, limitations of food charity and the need for structural solutions to this important issue.
Initial Health Outcomes of a Community-Based Collaboration for Children in Foster Care
Authors: Espeleta Hannah C , Schelbe Lisa , Ruggiero Kenneth J , Klika J Bart 
Published: December 2023

Abstract
Children entering foster care have complex health needs that can persist across the lifespan. Efforts to improve access to primary care services exist; however, few have been tested. This study evaluated the Missoula Foster Child Health Program, a tri-agency, community-based collaboration in Montana, to determine its impact on health outcomes for youth in care. Demographic, health outcome, and child welfare data were collected from 485 children (50 percent male, 50 percent female, aged 0–18). At program admission, children had unmet service needs, lacking a primary care provider (30 percent), a dental provider (58 percent), and required vaccinations (33 percent). Three-quarters of children had at least one health condition, and one-third had a behavioral health concern. Overall, children in the program had significant decreases in physical and behavioral health problems from admission to discharge. Older children and those with fewer placements were more likely to have positive health changes. Data are promising, representing positive health outcomes of a community-based model for children in care.
Oral β-Lactam Pairs for the Treatment of Mycobacterium avium Complex Pulmonary Disease
Authors: Negatu Dereje A , Shin Sung Jae , Kim Su-Young , Jhun Byung Woo , Dartois Véronique , Dick Thomas 
Published: December 2023

Abstract
Cure rates for pulmonary disease caused by the Mycobacterium avium complex (MAC) are poor. While β-lactam are front line antibiotics against Mycobacterium abscessus pulmonary disease, they have not been used or recommended to treat MAC lung infections. Through a comprehensive screen of oral β-lactams, we have discovered that selected pairs combining either a penem/carbapenem or penicillin with a cephalosporin are strongly bactericidal at clinically achieved concentrations. These dual β-lactam combinations include tebipenem and sulopenem, both in phase 3, and Food and Drug Administration-approved amoxicillin and cefuroxime. They could therefore immediately enter clinical trials or clinical practice.
Contextualizing the Contextualizers: How the Area Studies Controversy is Different in Different Places
Authors: Busse Jan , Valbjørn Morten , Doolotkeldieva Asel , Ortmann Stefanie , Smith Karen , Shami Seteney , Costa Sérgio , Weipert-Fenner Irene , Wolff Jonas , Schäfer Saskia , Osterberg-Kaufmann Norma 
Published: December 2023

Abstract
As part of recent years’ efforts at reaching a more context- and diversity-sensitive study of international relations, the nexus between fields of IR and Area Studies (AS) has received a renewed attention. While AS is usually presented as the “contextualizer” of the disciplines, this forum reverses the perspective by suggesting that an awareness of both diversity and context is also relevant when it comes to understanding the evolution of the field of AS and its relations to IR. In this forum, a selection of scholars with diverse backgrounds (US, Middle East, Europe, Latin America, Africa, and Central Asia), different (inter)disciplinary trainings and regional orientations examines how various fields of AS and its relations to the disciplines vary, and what follows from a stronger attention to such kind of diversity. By contextualizing the contextualizers, the forum brings attention to how a context-sensitive field can also suffer from its own provincialism. While the US-centric narrative about AS might have been almost “hegemonic,” at closer inspection, it turns out that AS in different (sub)disciplinary and geographical settings have evolved differently, and in some places the so-called Area Studies controversy (ASC) has been almost absent. A broadening of the perspective also reveals how the challenges to a successful cross-fertilization are not limited to those outlined in the “classic” ASC, but the forum does simultaneously offer encouraging lessons on how dialogues between area specialists and discipline-oriented scholars can help to overcome epistemological, theoretical, or methodological blind spots. Rather than presenting the IR/AS nexus as a panacea per se, the aim of the forum is therefore to invite to a broader and more self-reflective discussion on some of the opportunities as well as challenges associated with this strategy for making the study of international relations more context-sensitive and attentive to different forms of diversity.
Storytelling of Indigenous patient and family advocates engaged in patient-oriented research initiatives in the field of inflammatory bowel disease
Authors: Sanderson Rhonda , Porter Linda , Porter Robert , Brass Colten , Jennings Derek , Johnson-Jennings Michelle , Andkhoie Mustafa , Bukassa-Kazadi Germain , Fowler Sharyle , Santos Jose Diego Marques , Osei Jessica Amankwah , Quintin Carol-Lynne , Teucher Ulrich , Peña-Sánchez Juan Nicolás 
Published: December 2023

Abstract

Background and aim
The history of colonization and its ongoing impact poses significant health disparities among Indigenous communities. We aimed to centre the voices and stories of Indigenous patients and family advocates (IPFAs—Indigenous patients living with inflammatory bowel disease [IBD] and family members of Indigenous individuals with IBD) engaged in patient-oriented research projects and who are part of the IBD among Indigenous Peoples Research Team (IBD-IPRT).

Methods
IPFAs and Indigenous and non-Indigenous researchers of the IBD-IPRT followed a storytelling research methodology to let IPFAs share their stories as research team members. Four IPFAs documented their experiences as IBD patients, advocates, and research partners. The stories were analyzed for themes. The identified themes were collaboratively verified with the IPFAs.

Results
The full stories shared by the IPFAs were transcribed and presented in this paper. Following a background analysis of themes in the 4 narratives, we were also able to identify 4 key themes that could be relevant to improving patient-oriented research initiatives: (1) health promotion, (2) leadership and voice, (3) community engagement, and (4) disease awareness and access to care. Trust building, strong relationships, and effective partnerships are core components for conducting patient-oriented research with Indigenous community members.

Conclusions
Indigenous patient engagement in health research is crucial to ensure that lived experiences, knowledge, and cultural values are adequately adopted to improve research outcomes. Centering IPFAs in IBD research can promote cultural awareness and actionable recommendations to improve health outcomes for individuals with IBD and their families and caregivers.
Lipocalin-2 as a mediator of neuroimmune communication
Authors: Afridi Ruqayya , Kim Jae-Hong , Bhusal Anup , Lee Won-Ha , Suk Kyoungho 
Published: December 2023

Abstract
Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and nonimmune cells throughout the body. Importantly, the surge in lipocalin-2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of lipocalin-2, which plays a definitive role in determining their functional phenotypes. In different central nervous system pathologies, an increased expression of glial lipocalin-2 has been linked to neurotoxicity. Lipocalin-2 mediates a crosstalk between central and peripheral immune cells under neuroinflammatory conditions. One intriguing aspect is that elevated lipocalin-2 levels in peripheral disorders, such as cancer, metabolic conditions, and liver diseases, potentially incite an inflammatory activation of glial cells while disrupting neuronal functions. This review comprehensively summarizes the influence of lipocalin-2 on the exacerbation of neuroinflammation by regulating various cellular processes. Additionally, this review explores lipocalin-2 as a mediator of neuroimmune crosstalk in various central nervous system pathologies and highlights the role of lipocalin-2 in carrying inflammatory signals along the neuroimmune axis.
Morphomics via next-generation electron microscopy
Authors: Son Raku , Yamazawa Kenji , Oguchi Akiko , Suga Mitsuo , Tamura Masaru , Yanagita Motoko , Murakawa Yasuhiro , Kume Satoshi 
Published: December 2023

Abstract
The living body is composed of innumerable fine and complex structures. Although these structures have been studied in the past, a vast amount of information pertaining to them still remains unknown. When attempting to observe these ultra-structures, the use of electron microscopy (EM) has become indispensable. However, conventional EM settings are limited to a narrow tissue area, which can bias observations. Recently, new trends in EM research have emerged, enabling coverage of far broader, nano-scale fields of view for two-dimensional wide areas and three-dimensional large volumes. Moreover, cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological bioimages. Taken together, these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology, which now arises as a new omics science termed ‘morphomics’.
Potential interactions between triazole antifungal agents and lorlatinib based on ultra-performance liquid chromatography-tandem mass spectrometry in rat plasma
Authors: Ye Zhongjiang , Wang Chenxiang , Li Rongqi , Chen Chuang , Yang Jianhui , Chen Yizhang , Fu Jing , Zhou Tao , Jin Mi , Huang Aifang , Zhang Xiuhua , Zhou Ziye 
Published: December 2023

Abstract

Aim
Our study is to investigate the effects of triazole antifungal drugs on the pharmacokinetics of lorlatinib in rats.

Methods
The samples were precipitated with methanol. Chromatographic separation was performed on a ultra-performance liquid chromatography (UPLC) system using a BEH C18 column. The mobile phase consisted of 0.1% formic acid water and methanol. Lorlatinib and crizotinib (internal standard) were detected in multiple reaction monitoring mode. The fragment ions were 407.3–228.07 for lorlatinib and m/z 450.3–260.0 for crizotinib. Lorlatinib and different triazole antifungal drugs were given to Sprague Dawley rats by gavage, and blood was collected from the tail vein at a certain time point. The validated UPLC–MS/MS method was applied to a drug interaction study of ketoconazole, voriconazole, itraconazole, and posaconazole with lorlatinib in rats.

Results
Ketoconazole and voriconazole significantly inhibited lorlatinib metabolism. When administration with ketoconazole and voriconazole, the area under the curve from time zero to infinity of lorlatinib increased by 49.0% and 104.3%, respectively; the clearance decreased by 40.0% and 40.0%, respectively. While itraconazole and posaconazole did not affect lorlatinib pharmacokinetics.

Conclusion
The UPLC-MS/MS-based assay is helpful to further understand the pharmacokinetics of lorlatinib in rats, and confirmed the findings that the combination of lorlatinib with CYP3A inhibitors should be avoided as predicted by our pre-clinical studies.
The Exploration of the GWOT Combat Amputee’s Experience With Longitudinal Care: A Qualitative Study
Authors: Pursel Alexander , Nichols Ryoma , Evans Dan , Lindquist Kristina 
Published: December 2023

ABSTRACT

Introduction
Contemporary advances in combat medicine have allowed greater numbers of wounded service members to survive their injuries. An estimated 1,705 combat veterans sustained major lower or upper extremity amputations between 2001 and 2017 during the Global War on Terror. This study intends to answer the following question utilizing a qualitative study design: What were the common and abnormal experiences of the Global War on Terror combat amputees relative to their mechanism of injury, perception of injury, and systems of care utilized during their recovery and rehabilitation process?.

Methods
During the months of December 2022 and January 2023, individual semi-structured interviews were conducted with U.S. Marines that served in the Global War on Terror (total n = 10). Deductive and inductive approaches were employed to identify codes, themes, and meta-themes in the data.

Results
All participants deployed to Afghanistan between the years 2010 and 2014 and were assigned to the following military occupational specialties: Explosive Ordnance Disposal technicians (total n = 2); combat engineers (total n = 2); and infantrymen (total n = 6). Analysis of data collected from interviews highlighted these key observations: (1) Themes in the combat amputee experience include support, systems of care, and mindset and (2) the themes synergistically contribute to the meta-themes mental health and pain and vice versa. As all participants were subjected to a blast mechanism of injury, it is difficult to determine if this played a role in deviating rehabilitation and recovery processes. Perception of injury and how well participants adapted to their new lifestyle, meaning how optimistic they were, appeared to play a significant role in recovery. Participants had mixed feelings about the care they had received but generally spoke favorably of military hospitals and were frustrated with the Veteran Affairs, and there was no clear consensus on their relationship with civilian health care, though most participants chose to seek most of their care through the Veteran Affairs.

Conclusion
Based on the research question, this study found an intricate relationship between mental health, pain, and the experiences of the participants regarding their care and rehabilitation. However, the nature of qualitative research makes it impossible to determine generalizations that can be used to create meaningful change to address improving combat amputee veteran care. Further research into long-term health outcomes based on hypotheses not evaluated in existing literature would further improve the ability of health care providers to care for this unique patient population.
Toward image-based personalization of glioblastoma therapy: A clinical and biological validation study of a novel, deep learning-driven tumor growth model
Authors: Metz Marie-Christin , Ezhov Ivan , Peeken Jan C , Buchner Josef A , Lipkova Jana , Kofler Florian , Waldmannstetter Diana , Delbridge Claire , Diehl Christian , Bernhardt Denise , Schmidt-Graf Friederike , Gempt Jens , Combs Stephanie E , Zimmer Claus , Menze Bjoern , Wiestler Benedikt 
Published: December 2023

Abstract

Background
The diffuse growth pattern of glioblastoma is one of the main challenges for accurate treatment. Computational tumor growth modeling has emerged as a promising tool to guide personalized therapy. Here, we performed clinical and biological validation of a novel growth model, aiming to close the gap between the experimental state and clinical implementation.

Methods
One hundred and twenty-four patients from The Cancer Genome Archive (TCGA) and 397 patients from the UCSF Glioma Dataset were assessed for significant correlations between clinical data, genetic pathway activation maps (generated with PARADIGM; TCGA only), and infiltration (Dw) as well as proliferation (ρ) parameters stemming from a Fisher–Kolmogorov growth model. To further evaluate clinical potential, we performed the same growth modeling on preoperative magnetic resonance imaging data from 30 patients of our institution and compared model-derived tumor volume and recurrence coverage with standard radiotherapy plans.

Results
The parameter ratio Dw/ρ (P &lt; .05 in TCGA) as well as the simulated tumor volume (P &lt; .05 in TCGA/UCSF) were significantly inversely correlated with overall survival. Interestingly, we found a significant correlation between 11 proliferation pathways and the estimated proliferation parameter. Depending on the cutoff value for tumor cell density, we observed a significant improvement in recurrence coverage without significantly increased radiation volume utilizing model-derived target volumes instead of standard radiation plans.

Conclusions
Identifying a significant correlation between computed growth parameters and clinical and biological data, we highlight the potential of tumor growth modeling for individualized therapy of glioblastoma. This might improve the accuracy of radiation planning in the near future.
Hidden Burden of Bartonella quintana on the African Continent: Should the Bacterial Infection Be Considered a Neglected Tropical Disease?
Authors: Boodman Carl , Fongwen Noah , Pecoraro Alfonso J , Mihret Adane , Abayneh Hiwot , Fournier Pierre-Edouard , Gupta Nitin , van Griensven Johan 
Published: December 2023

Abstract
Bartonella quintana is a louse-borne gram-negative bacillus that remains a poorly characterized cause of bacteremia, fever, and infective endocarditis. Due to the link with pediculosis, B quintana transmission is tied to poverty, conflict, overcrowding, and inadequate water access to maintain personal hygiene. Although these risk factors may be present globally, we argue that a substantial burden of undocumented B quintana infection occurs in Africa due to the high prevalence of these risk factors. Here, we describe the neglected burden of B quintana infection, endocarditis, and vector positivity in Africa and evaluate whether B quintana meets criteria to be considered a neglected tropical disease according to the World Health Organization.
Candida auris: A Systematic Review of a Globally Emerging Fungal Pathogen in Africa
Authors: Osaigbovo Iriagbonse I , Ekeng Bassey E , Davies Adeyinka A , Ebeigbe Ejime , Bongomin Felix , Kanyua Alice , Revathi Gunturu , Oladele Rita O 
Published: December 2023

Abstract
Candida auris is a World Health Organization critical priority fungal pathogen. We conducted a systematic review to describe its epidemiology in Africa. PubMed and Google scholar databases were searched between January 2009 and September 2023 for clinical studies on C. auris cases and/or isolates from Africa. Reviews were excluded. We included 19 studies, involving at least 2529 cases from 6 African countries with the most, 2372 (93.8%), reported from South Africa. Whole-genome sequencing of 127 isolates identified 100 (78.7%) as clade III. Among 527 isolates, 481 (91.3%) were resistant to fluconazole, 108 (20.5%) to amphotericin B, and 9 (1.7%) to micafungin. Ninety of 211 (42.7%) patients with clinical outcomes died. C. auris is associated with high mortality and antifungal resistance, yet this critical pathogen remains underreported in Africa. Collaborative surveillance, fungal diagnostics, antifungals, and sustainable infection control practices are urgently needed for containment.
Advances of presepsin in sepsis-associated ARDS
Authors: Wei Senhao , Shen Ziyuan , Yin Yiyuan , Cong Zhukai , Zeng Zhaojin , Zhu Xi 
Published: December 2023

Abstract
This article reviews the correlation between presepsin and sepsis and the resulting acute respiratory distress syndrome (ARDS). ARDS is a severe complication of sepsis. Despite the successful application of protective mechanical ventilation, restrictive fluid therapy, and neuromuscular blockade, which have effectively reduced the morbidity and mortality associated with ARDS, the mortality rate among patients with sepsis-associated ARDS remains notably high. The challenge lies in the prediction of ARDS onset and the timely implementation of intervention strategies. Recent studies have demonstrated significant variations in presepsin (PSEP) levels between patients with sepsis and those without, particularly in the context of ARDS. Moreover, these studies have revealed substantially elevated PSEP levels in patients with sepsis-associated ARDS compared to those with nonsepsis-associated ARDS. Consequently, PSEP emerges as a valuable biomarker for identifying patients with an increased risk of sepsis-associated ARDS and to predict in-hospital mortality.