bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work Will Not Save Us: An Asian American Crip Manifesto
Authors: Chen Mel Y. , Khúc Mimi , Kim Jina B. 
Published: December 2023

Drawing together disability justice, Asian American studies, and feminist/ queer-of-color labor analysis, this collaboratively authored essay forwards an anti-work manifesto shaped by our lived experiences as sick, disabled and queer Asian American scholars laboring in the academic-industrial complex. This essay offers a two-part intervention: first, it aims to expand nascent conversations on disability politics and its relationship to racial capitalism, and second, it puts forth a critique of the Asian American emphasis on achievement as an instrument of belonging and potential inoculation against racialized violence. It also unfolds in two parts: first, a section on why we refuse work, and second, a section on how to perform this refusal.

As we come to this essay from our respective positionalities in contingent, tenure-stream, and tenured academic loci, as well as from our shared investments in feminist and queer frameworks, the first section mobilizes feminist and queer disability analysis to interrogate the fraught investments in work shared across Asian American and Disability Studies, addressing the complexities of gendered, contingent, care, and service work within the academic landscape (and particularly as we have experienced them). The second section offers a survival guide for navigating the labor demands placed on racialized, queer, and/ or disabled scholars, channeling Asian American rage to move beyond saying “no” and toward saying “fuck off.”
Improving Local Community Public Services: Revealing Hurdles and Strategic Remedies
Authors: Wirahayu Choif Puspa , Mursyidah Lailul 
Published: December 2023

This research investigates the complexities within public service delivery at the Buduran Sub-District Office in Sidoarjo Regency, identifying issues arising from intricate procedures and demanding requirements. The study aims to uncover and analyze factors impacting the improvement of public service performance, employing a SWOT analysis to identify internal and external environmental factors. The strategic identification of five critical issues emerges, including inadequate infrastructure, public unfamiliarity with service procedures, limited service personnel, suboptimal workforce competencies, and administrative disorder at the village level. Corresponding strategic responses are proposed, such as infrastructure enhancement, intensified public education on service procedures, capacity building for civil servants, specialized recruitment in service areas, and fortified coordination with village administrations. The implications suggest targeted strategies for policymakers and public service administrators to address these challenges, thereby elevating service quality and responsiveness to societal needs.
Highlights:

SWOT Analysis: Identifying Internal and External Factors - Essential for strategic planning and understanding the landscape of service delivery challenges.
Critical Issues in Service Delivery: Infrastructure, Public Awareness, and Human Resources - Addressing these facets is pivotal for enhancing service quality and efficacy.
Strategic Responses: Infrastructure Development, Public Education, and Workforce Capacity Building - Implementing targeted strategies to address identified challenges and fortify service delivery mechanisms.

Keywords: Public Service, Performance Improvement, Strategic Solutions, SWOT Analysis, Community Engagement
Insights into glendonite formation from the upper Oligocene Sagavanirktok Formation, North Slope, Alaska, U.S.A.
Authors: Counts John W. , Vickers Madeleine L. , Stokes M. Rebecca , Spivey Whittney , Gardner Kristina F. , Self-Trail Jean M. , Gooley Jared T. , McAleer Ryan J. , Jubb Aaron M. , Houseknecht David W. , Lease Richard O. , Griffis Neil P. , Vickers Martin , Śliwińska Kasia , Tompkins Hannah G.D. , Hudson Adam M. 
Published: December 2023

Abstract
The type locality for the upper Oligocene Nuwok Member of the Sagavanirktok Formation (Carter Creek, North Slope, Alaska, USA) contains an abundant occurrence of glendonite, a pseudomorph after the calcium-carbonate mineral ikaite, which typically forms in the shallow subsurface of cold marine sediments. The region during the time of Nuwok Member deposition was located at a high latitude, similar to today, and the study site is characterized by sands and silty muds interpreted here to have been deposited in coastal and shelfal marine environments. Isotopic (Sr) and biostratigraphic (foraminifera) evidence presented here refine the depositional age of the outcrop to approximately 24 Ma. Glendonites occur in two basic forms: radial clusters, commonly centered around a single larger primary crystal (∼ 10 cm, Type A) and larger single blades generally without accessory crystals (∼ 15–25 cm, Type B).
Microscopic examination reveals a sequence of multiple types of replacive calcite that formed as a direct result of ikaite transformation: Type 1 rhombohedral crystals characterized by microporous and inclusion-rich cores and concentric zones, Type 2A, composed of clear calcite that overgrew and augmented Type 1 crystals, and inclusion-rich, microcrystalline Type 2B, which formed a matrix surrounding the rhombs and commonly dominates the outer rims of glendonite specimens. Type 3 calcite precipitated as fibrous, botryoidal epitaxial cement atop previous phases and is not ikaite-derived. These phases are distributed in similar ways in all examined specimens and are consistent with several previously described glendonite occurrences around the world, despite differing diagenetic and geologic histories. Stable-isotope evidence (δ13C and δ18O) suggests sourcing of glendonite carbon from both organic and methanogenic sources. Glendonites of the Nuwok Member can therefore assist in the determination of a more comprehensive ikaite transformation model, improving our understanding of glendonite formation and the sedimentological and environmental context of their occurrence. Oligocene glendonites are uncommon globally; the well-preserved occurrence described here can allow future studies to better reconstruct Arctic environmental conditions and paleoclimates during this time.
Media ajar pendamping bahasa inggris “let’s express” sebagai media dalam materi expression siswa SMP Kelas VII
Authors: Mutiatun Siti , Alami Ersa 
Published: December 2023

Bahasa adalah alat komunikasi yang diperlukan dalam setiap waktu termasuk siswa yang setiap hari berkomunikasi. Komunikasi lisan merupakan keterampilan berbahasa yang membutuhkan beberapa komponen berbahasa diantaranya adalah expression. Materi expression merupakan salah satu materi yang dipelajari siswa kelas VII SMP yang bertujuan agar komunikasi lisan mereka tidak kaku dalam menggunakan kosa kata. Dengan demikian, mereka bisa berbicara sesuai dengan alur situasi dan kondisi yang diinginkan tanpa menunjukkan sikap memaksa. Namun hal ini sangat sulit untuk diaplikasikan karena mereka harus menyesuaikan kegiatan yang ada pada buku ajar yang pada umumnya menggunakan situasi asing sehingga mereka harus menganalisis sebelum mereka memahami dan mengimplementasikan materinya. Tujuan dari penelitian ini adalah mendeskripsikan penggunaan media ajar pendamping bahasa Inggris “let’s express” dalam materi expression siswa kelas VII SMP Daruttauhid, Sepulu, Bangkalan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif yang berisi tentang paparan hasil penelitian yang merupakan paparan dari penggunaan media. Dari penelitian, diketahui bahwa siswa dan guru mengalami kesulitan dalam materi expression sehingga membutuhkan media khusus yang dapat membantu dalam pembelajarannya. Penggunaan media ajar pendamping bahasa Inggris dalam materi expression cukup membantu karena berbasis aplikasi yang berkearifan lokal sehingga dapat diakses dengan mudah dalam waktu tak terbatas.
Exposure to OPFRs is associated with obesity and dysregulated serum lipid profiles: data from 2017-2018 NHANES
Authors: Xing Weilong 
Published: December 2023

Abstract
Background Exposure to organophosphate flame retardant (OPFRs) is widespread in general population. Emerging studies revealed OPFRs have endocrine disturbing property. However, research investigating OPFRs exposure, obesity and serum lipid profiles is limited. We aim to evaluate the association between urinary metabolites of OPFRs, BMI, and serum lipid profiles.Methods Data from National Health and Nutrition Examination Survey (NHANES) 2017–2018 was obtained. 1334 adults were enrolled in the current study. Urinary concentrations of bis (1-chloro-2-propyl) phosphate (BCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), dibutyl phosphate (DBUP), and diphenyl phosphate (DPHP) were quantified to assess OPFRs exposure. Covariate-adjusted linear and logistic regression models were conducted to explore the associations between log2-transformed concentrations of OPFRs metabolites, BMI, obesity and serum lipid profiles. Stratified analyses were performed to assess the heterogeneity of associations by age, gender, race, etc.Results Increased urinary concentrations of BCEP and BDCPP were positively associated with 0.27 (95% CI: 0.02–0.52, p = 0.0338) and 0.56 (95% CI: 0.25–0.87, p = 0.0004) higher BMI value, respectively. One log2-unit increase in urinary BCEP concentrations was associated with 10% higher risk for developing obesity (95% CI: 1.02–1.18, p = 0.0096). Additionally, one log2-unit increase in BDCPP was associated with 19% higher risk for obesity (95% CI: 1.09–1.30, p = 0.0001). Multivariable linear regression showed urinary DPHP concentrations were inversely correlated with serum TG levels (β=-7.41, 95% CI: -12.13 to -2.68, p = 0.0022).Conclusion Environmental exposure to OPFRs might contribute to obesity and dysregulated serum lipid in adults. Future prospective researches are warranted to confirm the causal relationship between metabolites of OPFRs and obesity.
Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage
Authors: Yetkin-Arik Bahar , Jansen Suze A. , Varderidou-Minasian Souzanna , Westendorp Bart , Altelaar Maarten , Lindemans Caroline , Lorenowicz Magdalena 
Published: December 2023

Abstract

Background
Allogenic hematopoietic stem cell transplantation (HSCT) is a curative treatment for leukemia and a range of non-malignant disorders. The success of the therapy is hampered by occurrence of acute graft-versus-host disease (aGvHD); an inflammatory response damaging recipient organs, with gut, liver, and skin being the most susceptible. Intestinal GvHD injury is often a life-threatening complication in patients unresponsive to steroid treatment. Second-line available therapies are immunosuppressants or mesenchymal stromal/stem cell (MSCs) infusions. Data from our institution and others demonstrate rescue of approximately 40–50% of patients suffering from aGvHD with mesenchymal stromal/stem cells and minor side effects. Although promising, better understanding of MSC mode of action and patient response to MSC-based therapy is essential to improve this lifesaving treatment.
Methods
Single cell human small intestine organoids were embedded in Matrigel, grown for 5 days and treated with busulfan for 48 h. Organoids damaged by treatment with busulfan or control organoids were co-cultured with 5.000, 10.000, and 50.000 MSCs for 24 h, 48 h or 7 days and the analyses such as surface area determination, proliferation and apoptosis assessment, RNA sequencing and proteomics were performed.
Results
Here, we developed a 3D co-culture model of human small intestinal organoids and MSCs, which allows to study the regenerative effects of MSCs on intestinal epithelium in a more physiologically relevant setting than existing in vitro systems. Using this model we mimicked chemotherapy-mediated damage of the intestinal epithelium. The treatment with busulfan, the chemotherapeutic commonly used as conditioning regiment before the HSCT, affected pathways regulating epithelial to mesenchymal transition (EMT), proliferation, and apoptosis in small intestinal organoids, as shown by transcriptomic and proteomic analysis. The co-culture of busulfan-treated intestinal organoids with MSCs reversed the effects of busulfan on the transcriptome and proteome of intestinal epithelium, which we also confirmed by functional evaluation of proliferation and apoptosis.
Conclusions
Collectively, we demonstrate that our in vitro co-culture system is a new valuable tool to facilitate the investigation of the molecular mechanisms behind the therapeutic effects of MSCs on damaged intestinal epithelium. This could benefit further optimization of the use of MSCs in HSCT patients.
Risk Factors of Ocular Disorders among Institutionalized Adults with Intellectual Disabilities in Taipei City
Authors: Fang I-Mo , Hsieh Ching , Tsai Tzu-Hsun , Lin Fu-Gong , Chiu Yu-Lung 
Published: December 2023

Abstract

Purpose To investigate the risk factors of ocular disorders among institutionalized adults with intellectual disabilities (ID) in Taipei City.Methods A cross-section city-wide ophthalmic survey was conducted in Taipei City from 2016 to 2017, involving full-time residents with ID aged over 18. Participant characteristics, including age, gender, ID severity, and associated diseases, were collected for multiple logistic regression analysis to identify ocular disorder risk factors.Results A total of 687 participants, comprising 70.9% of the eligible individuals, were included. Refractive errors (73.8%), strabismus (32.6%), ocular hypertension (26.0%) and cataract (15.3%) were the most common ocular disorders Myopia (73.2%) is the most common refractive error, with 14.6% being high myopia. DS was a common risk factor for developing strabismus (OR,2.54; 95% confidence interval (CI), 1.58 to 4.08), nystagmus (OR, 9.24; 95% CI, 4.41 to 19.37), high myopia (OR,2.54; CI, 1.52 to 4.25), high astigmatism (OR, 3.54; CI, 2.06 to 6.10), and cataracts (OR, 5.54; CI, 3.07 to 9.97). while it served as a protective factor against ocular hypertension (OR, 0.15; CI, 0.04 to 0.62). CP was identified as a common risk factor for strabismus (OR,2.09; CI, 1.28 to 3.42), nystagmus (OR,5.41; CI, 2.39 to 12.24), and high myopia (OR, 2.33; CI, 1.35 to 4.03).Conclusions High prevalence of myopia, strabismus, ocular hypertension and cataract was observed in institutionalized adults with ID. DS and CP were more significant risk factors than ID severity for ocular disorders. Regular ophthalmic exams, particularly monitoring intraocular pressure, are crucial for this population.
Research on Impact Coefficient of Highway Bridges in Heavy-cargo Transportation Based on International Roughness Index
Authors: Bo Liu , wang laiyong , Huang Zhenyang 
Published: December 2023

Abstract
A vehicle–bridge coupled vibration model, which is based on the virtual work principle and the finite element method, is established to analyze the impact of heavy-cargo transportation on a precast box girder bridge. The model can accurately simulate the dynamic characteristics of the vehicle and the bridge. A new method to reconstruct the values of deck roughness based on the International Roughness Index (IRI) is developed, after which the reconstruction is introduced to the vehicle–bridge model. Results show that the impact coefficient, which corresponds to different IRI-based reconstruction samples, obey a normal distribution. Furthermore, deck roughness played a significant role in vehicle–bridge relationship. When the heavy-cargo vehicle crossed the precast box girder bridge at low speeds, the impact coefficient changed significantly. Finally, the linear fitting formulas of the IRI-based impact coefficient are established for future research reference.
Numerical Investigation of Double-Volute Balancing in Centrifugal Pumps
Authors: Kibar Ali , Yigit Kadri Suleyman 
Published: December 2023

Abstract

This study investigates the impact of radial hydraulic forces on centrifugal pump bearings and assesses the effectiveness of the double-volute balancing technique in mitigating these forces. Numerical simulations were conducted on centrifugal pumps with both single- and double-volute configurations while ensuring extended computational domains in the inlet and outlet sections for improved flow characteristics. Experimental validation was performed to validate the numerical findings and provide additional evidence of the efficiency of the technique used in the simulations. The simulations demonstrated a notable decrease in the radial hydraulic forces with the implementation of the double-volute configuration. The pressure differentials between the single- and double-volutes played a critical role in counteracting the unbalanced forces generated by the impeller. Consequently, adopting a double-volute centrifugal pump design resulted in a substantial reduction in impeller-induced forces and the forces exerted on the bearings, resulting in an approximate 50% decrease in radial forces.
Assessing the ability of a large language model to score free text medical student notes
Authors: Burke Harry B. , Hoang Albert , Lopreiato Joseph O. , King Heidi , Hemmer Paul , Montgomery Michael , Gagarin Viktoria 
Published: December 2023

Abstract
Background
Teaching medical students the skills required to acquire, interpret, apply, and communicate clinical information is an integral part of medical education. A crucial aspect of this process involves providing students with feedback regarding the quality of their free-text clinical notes. The objective of this project is to assess the ability of ChatGPT 3.5 (ChatGPT) to score medical students’ free text history and physical notes.
Methods
This is a single institution, retrospective study. Standardized patients learned a prespecified clinical case and, acting as the patient, interacted with medical students. Each student wrote a free text history and physical note of their interaction. ChatGPT is a large language model (LLM). The students’ notes were scored independently by the standardized patients and ChatGPT using a prespecified scoring rubric that consisted of 85 case elements. The measure of accuracy was percent correct.
Results
The study population consisted of 168 first year medical students. There was a total of 14,280 scores. The standardized patient incorrect scoring rate (error) was 7.2% and the ChatGPT incorrect scoring rate was 1.0%. The ChatGPT error rate was 86% lower than the standardized patient error rate. The standardized patient mean incorrect scoring rate of 85 (SD 74) was significantly higher than the ChatGPT mean incorrect scoring rate of 12 (SD 11), p = 0.002.
Conclusions
ChatGPT had a significantly lower error rate than the standardized patients. This suggests that an LLM can be used to score medical students’ notes. Furthermore, it is expected that, in the near future, LLM programs will provide real time feedback to practicing physicians regarding their free text notes. Generative pretrained transformer artificial intelligence programs represent an important advance in medical education and in the practice of medicine.
Evolution-guided Bayesian optimization for constrained multi-objective optimization in self-driving labs
Authors: Hippalgaonkar Kedar , Low Andre , Mekki-Berrada Flore , Gupta Abhishek , Ostudin Aleksandr , Xie Jiaxun , Vissol-Gaudin Eleonore , Lim Yee-Fun , Li Qianxiao , Ong Yew Soon , Khan Saif 
Published: December 2023

Abstract

The development of automated high-throughput experimental platforms has enabled fast sampling of high-dimensional decision spaces. To reach target properties efficiently, these platforms are increasingly paired with intelligent experimental design. However, current optimizers show limitations in maintaining sufficient exploration/exploitation balance for problems dealing with multiple conflicting objectives and complex constraints. Here, we devised an Evolution-Guided Bayesian Optimization (EGBO) algorithm that integrates selection pressure in parallel with a q-Noisy Expected Hypervolume Improvement (qNEHVI) optimizer; this not only solves for the Pareto Front (PF) efficiently but also achieves better coverage of the PF while limiting sampling in the infeasible space. The algorithm was developed together with a custom self-driving lab for seed-mediated silver nanoparticle synthesis, targeting 3 objectives (1) optical properties, (2) fast reaction, and (3) minimal seed usage alongside complex constraints. We demonstrated that, with appropriate constraint handling, EGBO performance improves upon state-of-the-art qNEHVI. Furthermore, across various synthetic multi-objective problems, EGBO showed significative hypervolume improvement, revealing the synergy between selection pressure and the qNEHVI optimizer. We also demonstrated EGBO’s good coverage of the PF as well as comparatively better ability to propose feasible solutions. We thus propose EGBO as a general framework for efficiently solving constrained multi-objective problems in high-throughput experimentation platforms.
Evaluation of Cry1Ac and Cry2A endotoxins in transgenic cotton cultivars with respect to plant growth periods and stages
Authors: Hanif Mahreen , Saeed Shafqat , Ali Mudssar , Ishtiaq Muhammad , Khan Zuluqrnain 
Published: December 2023

Abstract
Transgenic cotton has brought about a significant transformation in the management of bollworms. Nevertheless, a considerable challenge has emerged in the form of Pectinophora gossypiella for transgenic cotton. In this research endeavor, we conducted the detection and quantification of Cry1Ac and Cry2Ab protein in field and pot samples of various transgenic cotton cultivars encompassing single, double, and triple gene varieties, employing Bt strips and ELISA methods. The extent of Bt protein production in both field and pot leaf samples across all examined cultivars was assessed at three distinct time points, namely 40, 80, and 120 days after sowing, coinciding with different growth phases (i.e., leaves, squares, bolls, and seeds). The outcomes revealed that heightened levels of Cry1Ac protein were present across all cultivars, whereas elevated levels of Cry2A protein were exclusively observed in the C6 (MNH-1045) cultivar. Bt proteins, namely Cry1Ac and Cry2Ab, exhibited variable concentrations depending on the specific cultivar, growth phase of the crop, and section of the plant. The findings underscored discernible differences in the concentrations of Cry1Ac and Cry2A proteins among all cultivars, while these concentrations also varied across different crop growth periods (i.e., 40, 80, and 120 days) and growth stages (i.e., leaf, square, bolls, and seed). It was discerned that the expression of toxins is contingent upon the developmental stage of the crop and the duration of growth. All of the transgenic cultivars displayed susceptibility to P. gossypiella. However, the triple-gene cultivar exhibited superior resistance. The incidence of P. gossypiella infestations increased in tandem with crop growth. The findings from this investigation are anticipated to provide valuable insights for entomologists and plant breeders, aiding them in devising suitable strategies, such as refuge maintenance or hybrid development, to safeguard transgenic cotton from pink bollworm infestations, thereby contributing to the sustainability of cotton production on a global scale.