bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liaisons variables et pataquès dans un corpus de chansons de tradition orale
Authors: Coutanson Gasparde , Badin Flora 
Published: October 2023

Dans cette contribution, nous nous intéressons au lien qu’entretiennent la liaison et l’écrit, que ce soit au niveau de l’acquisition ou dans les productions de locuteurs analphabètes, en relevant au passage quelques graphies non conventionnelles. Nous étudions notamment un corpus ethnomusicologique de 498 chansons (18h23min, 89 853 mots, 5 787 contextes de liaison), le fonds Jean Dumas, recueilli en France dans les années 60. Ce corpus est remarquablement liaisonnant pour des chants transmis oralement et interprétés par des locuteurs pas ou peu lettrés et, en l’absence de pressions normatives de l’écrit, on y observe également un grand nombre de pataquès. Pour autant, les chanteurs semblent percevoir certaines subtilités linguistiques que la maîtrise de l’écrit aide normalement à saisir, comme le fait que les liaisons en [t] apparaissent après des verbes conjugués à la troisième personne.
Travail social, psychiatrie et alcoolisme dans les années 1950 au prisme des dossiers d’une consultation parisienne
Authors: Bras Anatole Le 
Published: October 2023

À partir de l’observatoire d’une « consultation antialcoolique » ouverte en 1954 dans le 13e arrondissement de Paris, cet article étudie la manière dont le travail social a investi le nouveau champ d’action du suivi psychiatrique de l’alcoolisme, dans un contexte de mutations de la prise en charge médicale de cette maladie. Le contenu autant que la structure des dossiers de patients de la consultation, que nous mettons en regard avec des publications issues de revues médicales et de travail social, permettent d’approcher le travail quotidien des assistantes sociales, au plus près des alcooliques et de leurs familles. Nous montrons que l’action de l’assistante sociale, devenue centrale bien que subordonnée à celle du médecin psychiatre, s’enrichit d’une dimension psychothérapique et se caractérise par la recherche de la confiance du malade et de son adhésion au traitement, marquant ainsi une inflexion nette dans le rapport aux populations assistées. Cependant, ces évolutions ne suffisent pas à débarrasser le travail social de ses ambiguïtés constitutives et notamment de ses fonctions de contrôle et de surveillance, sources de difficultés, de malentendus et de conflits avec les malades et leurs proches.
Les théories de l’ordre social spontané à l’épreuve d’un retour du dessein : Mandeville et Hayek
Authors: Francatel Laurent 
Published: October 2023

Bernard Mandeville est souvent présenté comme l’un des penseurs les plus importants des théories de l’ordre social spontané. Selon Friedrich August Hayek, B. Mandeville, dans son ouvrage La fable des abeilles (1714), rend possible une conception radicalement renouvelée de l’ordre social. L’ordre social est-il le produit d’un dessein humain ou, au contraire, faut-il voir en lui le résultat d’une formation spontanée ? Loin d’être le produit d’une quelconque intention humaine, l’ordre observé dans la société est le résultat d’un processus autorégulé et autoperpétuant. L’approche de Mandeville a pour but d’invalider toute forme de constructivisme social. La société est alors perçue comme un « édifice sans architecte » (Gilles Dostaler, Le libéralisme de Hayek). À l’instar des penseurs des Lumières écossaises, Mandeville soutient que l’ordre social est le produit de l’action des hommes mais non celui de leur intention.Cependant, ni Mandeville ni Hayek ne parviennent à éliminer radicalement la notion de dessein de leur approche de l’ordre social. Cet article a pour objectif de démontrer la permanence d’un dessein y compris dans les théories de l’ordre social spontané.
Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats
Authors: Xu Jijun , Huang Ping , Bie Bihua , Dai Yang , Ben-Salem Salma , Borjini Nozha , Zhang Lingjun , Chen Jin , Olman Mitchell , Cheng Jianguo , Lin Feng 
Published: October 2023

Abstract
Cancer chemotherapy-induced neuropathic pain is a devastating pain syndrome without effective therapies. We previously reported that rats deficient in complement C3, the central component of complement activation cascade, showed a reduced degree of paclitaxel-induced mechanical allodynia (PIMA), suggesting that complement is integrally involved in the pathogenesis of this model. However, the underlying mechanism was unclear. Complement activation leads to the production of C3a, which mediates inflammation through its receptor C3aR1. In this article, we report that the administration of paclitaxel induced a significantly higher expression level of C3aR1 on dorsal root ganglion (DRG) macrophages and expansion of these macrophages in DRGs in wild-type (WT) compared with in C3aR1 knockout (KO) mice. We also found that paclitaxel induced less severe PIMA, along with a reduced DRG expression of transient receptor potential channels of the vanilloid subtype 4 (TRPV4), an essential mediator for PIMA, in C3aR1 KO than in WT mice. Treating WT mice or rats with a C3aR1 antagonist markedly attenuated PIMA in association with downregulated DRG TRPV4 expression, reduced DRG macrophages expansion, suppressed DRG neuron hyperexcitability, and alleviated peripheral intraepidermal nerve fiber loss. Administration of C3aR1 antagonist to TRPV4 KO mice further protected them from PIMA. These results suggest that complement regulates PIMA development through C3aR1 to upregulate TRPV4 on DRG neurons and promote DRG macrophage expansion. Targeting C3aR1 could be a novel therapeutic approach to alleviate this debilitating pain syndrome.
Immune Activation Profiles Elicited by Distinct, Repeated TLR Agonist Infusions in Rhesus Macaques
Authors: King Hannah A D , Pokkali Supriya , Kim Dohoon , Brammer Daniel , Song Kaimei , McCarthy Elizabeth , Lehman Chelsea , Todd John-Paul , Foulds Kathryn E , Darrah Patricia A , Seder Robert A , Bolton Diane L , Roederer Mario 
Published: October 2023

Abstract
TLR agonists are a promising class of immune system stimulants investigated for immunomodulatory applications in cancer immunotherapy and viral diseases. In this study, we sought to characterize the safety and immune activation achieved by different TLR agonists in rhesus macaques (Macaca mulatta), a useful preclinical model of complex immune interactions. Macaques received one of three TLR agonists, followed by plasma cytokine, immune cell subset representation, and blood cell activation measurements. The TLR4 agonist LPS administered i.v. induced very transient immune activation, including TNF-α expression and monocyte activation. The TLR7/8 agonist 2BXy elicited more persistent cytokine expression, including type I IFN, IL-1RA, and the proinflammatory IL-6, along with T cell and monocyte activation. Delivery of 2BXy i.v. and i.m. achieved comparable immune activation, which increased with escalating dose. Finally, i.v. bacillus Calmette–Guérin (BCG) vaccination (which activates multiple TLRs, especially TLR2/4) elicited the most pronounced and persistent innate and adaptive immune response, including strong induction of IFN-γ, IL-6, and IL-1RA. Strikingly, monocyte, T cell, and NK cell expression of the proliferation marker Ki67 increased dramatically following BCG vaccination. This aligned with a large increase in total and BCG-specific cells measured in the lung. Principal component analysis of the combined cytokine expression and cellular activation responses separated animals by treatment group, indicating distinct immune activation profiles induced by each agent. In sum, we report safe, effective doses and routes of administration for three TLR agonists that exhibit discrete immunomodulatory properties in primates and may be leveraged in future immunotherapeutic strategies.
Development and Validation of the Athletic Training Student—Soft Skills Assessment Instrument
Authors: Davlin-Pater Christina 
Published: October 2023

ContextEducation of athletic training students should include the acquisition of soft skills. Evaluation of soft skills is important but challenging. Multisource performance reviews can provide students with feedback from different viewpoints, which can be used to promote self-awareness and encourage reflection.ObjectiveTo develop and validate a new multisource soft skills assessment tool for master’s level professional athletic training students.DesignCross-sectional study.SettingWeb-based questionnaires.Patients or Other ParticipantsNineteen participants evaluated the instrument for face and content validity. These participants included 5 athletic training educators, 7 athletic training preceptors, and 7 students currently enrolled in a graduate-level, Commission on Accreditation of Athletic Training Education-accredited athletic training education program. Participants in the first pilot test included 22 students, 22 preceptors, and 3 instructors. Participants in the second pilot test included 28 students, 32 preceptors, and 3 instructors.Data Collection and AnalysisA 3-stage process was used to develop and validate the instrument. The process included a literature review and formation of 65 survey items organized into 11 themes. Questions were reviewed by students, preceptors, and instructors. Responses were analyzed using content validity ratio to help identify items needing revision, deletion, or substitution. All open responses were considered. Based on results, 1 question was removed, and 2 questions were updated to improve clarity. The updated Athletic Training Student—Soft Skills Assessment instrument includes 64 questions. In the final stage, reliability analysis was conducted on 2 samples. Internal consistency was examined with Cronbach α and interitem correlations.ResultsUsing a rigorous content validation approach provided evidence that the instrument was comprehensive, clear, and complete enough to establish the tool’s credibility in the preliminary stages.Conclusion(s)The outcome of this study is a multisource soft skills assessment tool that can provide students with formative feedback.
Chryseobacterium/Elizabethkingia species infections in children
Authors: Yahşi Aysun , Bayhan Gülsüm İclal , Erat Tuğba , Güney Ahmet Yasin , Özen Seval , Konca Kübra , Gülhan Belgin , Yüksek Saliha Kanık , Parlakay Aslınur Özkaya 
Published: October 2023

Objective:
To investigate the clinical and epidemiological features and outcome of Chryseobacterium and Elizabethkingia spp. infections in children, together with antimicrobial susceptibilities.

Methods:
This retrospective study was conducted at a tertiary pediatric hospital in Turkey. All patients infected with Chryseobacterium/Elizabethkingia spp. among those presenting to Ankara City Hospital between March 2014 and March 2022 were included.

Results:
A total of 49 cases were included and 29 cases were identified as Elizabethkingia. The median age was 14 (0.2-185.0) months. The majority (89.8%) of these patients had an underlying disease, including malignancy (42.9%). Bacteremia (46.9%) and central line-associated bloodstream infection (28.6%) were the most common infections. The thirty-day all-cause mortality rate was 12.2%. The most commonly used antibiotics were ciprofloxacin and trimethoprim-sulfamethoxazole (TMP-SMX). Forty-five (91.8%) isolates were susceptible to ciprofloxacin, 44 (91.6%) to TMP-SMX, and 21 (87.5%) to levofloxacin.

Conclusions:

Chryseobacterium and Elizabethkingia spp. are emergent, nosocomial pathogens and the majority of cases were older than the neonatal period. They were mainly seen in patients with long hospital stays, indwelling devices, and those who have received antibiotics within the last month, especially carbapenems. In addition, they were associated with bloodstream infection and malignancy. The most commonly useful antibiotics according to the resistance patterns were ciprofloxacin and TMP-SMX.
Behaviour and perception of parents on irrational use of antibiotics in children at primary care level
Authors: Mete Burak , Salcan Tarik , Demirhindi Hakan 
Published: October 2023

Objective:To investigate the perception of antibiotics, the frequency of inappropriate antibiotic use, and the factors that lead to inappropriate antibiotic use by parents who apply to primary healthcare organizations.Methods:This cross-sectional study included 973 parents who applied to primary healthcare centers. We analyzed basic concepts related to antibiotics prescribed for their children, antibiotic administration, and antibiotic resistance, as well as parents' knowledge and attitudes towards antibiotic use, and their experiences, practices, and perceptions related to purchasing antibiotics without prescription.Results:In the past one year, 78.9% of the parents gave antibiotics to their children at least once, and 39.1% gave antibiotics three or more times. Some of the participants (7.1%) reported having forced the physician to prescribe antibiotics and purchased antibiotics without a prescription (13.2%). The knowledge about antibiotics and awareness about antibiotic resistance were found to be more frequent; among parents who had university degrees, higher income levels, two or fewer children, social insurance and negative behaviours were lower in those who received information about antibiotics from healthcare professionals. The probability of taking antibiotics without prescription was lower in that of with higher income level (OR0.460; 95%CI0.219-0.965), and the probability of forcing antibiotic prescription was higher in those with 3 or more children (OR6.94; 95%CI2.37-20.26). The score obtained from the awareness of antibiotic resistance sub-dimension was found to negatively affect the behavior of forcing antibiotic prescription (OR0.852; 95%CI0.732-0.993) but the score obtained from the behaviour sub-dimension was positively affect this behaviour (OR1.136; 95%CI1.011-1.276).Conclusions:Inappropriate antibiotic use appears to be a problem with negative perception, lack of knowledge and socioeconomic dimension. Studies should be conducted to increase antibiotic knowledge in parents and to expand the scope of social insurance.
Wide-field digital imaging system for assessing ocular anterior segment development in very preterm infants
Authors: Wang Yu-jing , Ke Min , Yan Ming 
Published: October 2023

Purpose:
This study aims to longitudinally investigate developments of the anterior segment in very preterm infants who exhibit normal retinal development outcomes by utilizing a wide-field digital imaging system.

Methods:
Between June 2021 and June 2022, neonates with a birth weight of <1500 g and/or a gestational age (GA) of less than 32 weeks were included in this study. The participants underwent regular ocular examinations, including sequential evaluations of the anterior segment and the retina, at intervals of 2–5 weeks, starting from birth and continuing until they reached a corrected GA of 48 weeks. Term neonates were selected as normal controls for the study. The study recorded the weight and GA of subjects at the time of examination, as well as indicators of abnormal development in the anterior segment.

Results:
A total of 48 very preterm infants with normal retinal developmental outcomes were enrolled. The control group included 59 full-term infants. Common anterior segment eye abnormalities such as persistent hyperplasia of primary vitreous, persistent pupillary membranes, iris vessels, and anterior chamber angle vessels gradually subsided with the period in very preterm infants. The vascularity of the iris was substantially higher than in term controls (P < 0.05) at term gestation. The imaging of iris vessels and anterior chamber angle vessels in very preterm infants exhibited a decline at 46 and 47 weeks, respectively, which occurred slightly later compared to term infants.

Conclusion:
In very preterm infants with normal outcomes, although the developmental process is delayed, they may form a normal anterior segment structure similar to that of full-term infants in the late stages, which is followed up by the wide-field digital imaging system.
Epidemiological and microbiological profiles of microbial keratitis in a tertiary eye center in Eastern India (Bihar)
Authors: Kusumesh Rakhi , Ambastha Anita , Arya Lalan K , Kumari Anita , Kumari Neha , Sinha Bibhuti P , Mohan Nilesh , Kumari Namrata 
Published: October 2023

Purpose:
To determine the demography, risk factors, and causative organisms of microbial keratitis (MK) in Bihar, an eastern state of India.

Design:
Retrospective study.

Methods:
We reviewed the demographic, clinical, and microbiological data of 2303 patients with MK (non-viral) presenting between January 2019 and December 2022.

Results:
This study revealed a predominance of males (65.0%) compared to females (34.9%), with a mean age of 48.4 ± 16.5 years. The majority of patients (63.1%) presented after 2 weeks from the onset of symptoms. The most common risk factor observed was corneal injury (58.1%), followed by ocular surface diseases (13.6%) and diabetes mellitus (13.3%). The majority of patients (73.16%) were involved in agriculture. Prior to presentation, almost all patients (92%) had received topical antibiotics. Unsupervised use of topical corticosteroids was observed in 29.2% of the patients for the median duration of 3 days (odds ratio, 0.17). At presentation, the median size of corneal ulcers was 5 mm, the best-corrected visual acuity was less than 20/400 in 51.4% of patients, and corneal perforation was in 14% of patients. The smear and culture positivity rate were 75.4% and 47.9%, respectively. The common causative organism was fungus (48.8%), followed by bacteria (17.4%). Aspergillus spp. and Staphylococcus spp. were the most commonly identified organisms; a quarter of the patients (24.5%) remained unidentified. All bacteria showed good sensitivity to vancomycin.

Conclusion:
MK is a significant cause of ocular morbidity in Bihar. The knowledge of epidemiology, risk factors, and microbiological profiles of MK can provide a valuable approach to disease prevention, diagnosis, and management.
Clinical feature of cystoid macular degeneration in central serous chorioretinopathy
Authors: Gorhe Sukanya , Chugh Manpreet Kaur , Goel Nikita , D’Souza Zubin , Saurabh Kumar , Roy Rupak 
Published: October 2023

Purpose:
Cystoid macular degeneration (CMD) is a feature of chronic central serous chorioretinopathy (CSCR). Present study intended to analyze the clinical presentation, risk factors, choroidal features, and outcome of CMD in CSCR.

Methods:
This was a retrospective, record-based descriptive study, which included chronic CSCR eyes with CMD. Demographic profile and clinical history were obtained from medical records. Spectralis spectral domain optical coherence tomography (SDOCT; Heidelberg Engineering, Germany) was used for acquiring SDOCT images and for performing fluorescein angiography, indocyanine green angiography, and optical coherence tomography (OCT) angiography.

Results:
The study included 101 eyes of 69 consecutive patients of CSCR having CMD. The mean age of patients was 56 ± 9.4 years (range 40–79 years), and majority (63, 91.3%) of the patients were male. Prior history of corticosteroid use was present in seven (10.1%) patients. Mean time interval between the first diagnosis of CSCR and appearance of CMD was 55.3 ± 33.9 months. CMD was located away from the fovea in majority of eyes (68, 67.3%). Mean subfoveal choroidal thickness was 396.71 ± 90.5 µm. Subretinal pigment epithelium choroidal neovascularization was noted in four (3.96%) eyes.

Conclusion:
CMD appears as a late complication of CSCR and is usually present away from the fovea. Such eyes had thickened choroid and fewer cases had associated choroidal neovascularization. Further comparative studies would be needed to validate these findings.
Surgical outcomes of bilateral lateral rectus recession versus unilateral recession and resection for the divergence excess type of intermittent exotropia
Authors: Han Mengya , Shen Tao , Wang Xiangjun , Yu Xinping , Zhu Binbin , Wen Yun , Yan Jianhua 
Published: October 2023

Purpose:
To compare bilateral lateral rectus recession (BLR) with unilateral recession and resection (RR) for divergence excess intermittent exotropia (IXT).

Methods:
Retrospective analysis of 66 patients with divergence excess IXT who underwent either BLR or RR from January 2013 to December 2020 was conducted. Data on demographics, pre- and postoperative deviations, fusion, stereopsis, control, and accommodative convergence/accommodation ratio were collected. Success was defined as esodeviation ≤5 PD (prism diopter) to exodeviation ≤10 PD with a follow-up time of at least 8.0 ± 2.0 weeks.

Results:
BLR (42 cases) and RR (24 cases) groups had the same success rate (83.3%, P = 0.688) and similar reduced postoperative deviations both in distance and at near (P > 0.05). Near-distance disparity decreased significantly in both groups (P = 0.000) with no intergroup difference (P = 0.193).

Conclusion:
BLR and RR were equally effective for divergence excess IXT with comparable outcomes of both distance and near deviations.
Role of additional posterior barrage laser in type 1 zone 2 retinopathy of prematurity: A randomized trial
Authors: Regani Harika , Chandra Parijat , Kumawat Devesh , Chawla Rohan , Agarwal Ramesh , Vohra Rajpal 
Published: October 2023

Purpose:
The efficacy of additional barrage laser posterior to ridge in advanced stage 3 or stage 4 retinopathy of prematurity (ROP) is established, but its role in early stages is not defined. The objective was to study the efficacy of additional posterior barrage laser in type I zone 2 disease.

Methods:
In a randomized trial, patients with type I zone 2 ROP were recruited between February 2016 and May 2017. One eye of each baby was randomized into study and control groups, respectively. Laser photocoagulation anterior to ridge was given in the control group, and additional posterior barrage laser was performed in the study group. The outcome measures were time to complete ridge regression and final cycloplegic refraction at 3 months post-laser.

Results:
Forty patients (40 eyes per group) completed the required follow-up. The mean birth weight and gestational age were 1357 ± 338 g and 29.72 ± 2.57 weeks, respectively. The mean post-conceptional age during laser was 36.67 ± 3.23 weeks. The number of eyes achieving ridge regression in control and study groups was 8/40 (20%) and 27/40 (67%) at 2 weeks (P = 0.001) and 39/40 (97%) and 40/40 (100%) at 4 weeks (P = 0.4). The mean time to complete ridge regression was 3.74 ± 1.17 weeks and 2.62 ± 0.91 weeks in control and study groups, respectively (P < 0.001). The mean spherical equivalent at 12 weeks in control and study groups was -1.9 ± 2.3 Diopters and -2.4 ± 2.6 Diopters, respectively (P = 0.41).

Conclusions:
Additional posterior barrage laser leads to significantly faster regression of type 1 zone 2 ROP without increasing induced myopia and thereby might be a useful adjunct to conventional treatment in selected cases.

Trial registration number:
CTRI/2018/05/013779
Isogeny graphs on superspecial abelian varieties: eigenvalues and connection to Bruhat–Tits buildings
Authors: Aikawa Yusuke , Tanaka Ryokichi , Yamauchi Takuya 
Published: October 2023

AbstractWe study for each fixed integer
$g \ge 2$
, for all primes
$\ell $
and p with
$\ell \neq p$
, finite regular directed graphs associated with the set of equivalence classes of
$\ell $
-marked principally polarized superspecial abelian varieties of dimension g in characteristic p, and show that the adjacency matrices have real eigenvalues with spectral gaps independent of p. This implies a rapid mixing property of natural random walks on the family of isogeny graphs beyond the elliptic curve case and suggests a potential construction of the Charles–Goren–Lauter-type cryptographic hash functions for abelian varieties. We give explicit lower bounds for the gaps in terms of the Kazhdan constant for the symplectic group when
$g \ge 2$
. As a byproduct, we also show that the finite regular directed graphs constructed by Jordan and Zaytman also has the same property.