bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathologic Spectrum of Pediatric Posttransplant Lymphoproliferative Diseases Following Solid Organ Transplant
Authors: Cheng Jinjun , Wistinghausen Birte 
Published: December 2023

Context.—Posttransplant lymphoproliferative disorder (PTLD) remains a significant complication in pediatric patients undergoing solid organ transplant (SOT). The majority involve Epstein-Barr virus (EBV)–driven CD20+ B-cell proliferations, which respond to reduction of immunosuppression and anti-CD20–directed immunotherapy. Owing to the low overall incidence, prospective studies of pediatric PTLD are scarce, leading to a lack of comprehensive understanding of this disorder in pediatric populations. This review aims to bridge this knowledge gap by providing a comprehensive analysis of the clinical, morphologic, and molecular genetic features of PTLD in children, adolescents, and young adults after SOT.Objective.—To examine the clinical features, pathogenesis, and classification of pediatric PTLDs after SOT.Data Sources.—Personal experiences and published works in PubMed.Conclusions.—PTLD includes a broad and heterogeneous spectrum of disorders, ranging from nonmalignant lymphoproliferations to lymphomas. While most pediatric PTLDs are EBV+, an increasing number of EBV− PTLDs have been recognized. The pathologic classification of PTLDs has evolved in recent decades, reflecting advancements in understanding the underlying pathobiology. Nevertheless, there remains a great need for further research to elucidate the biology, identify patients at higher risk for aggressive disease, and establish optimal treatment strategies for relapsed/refractory disease.
Analisis penerapan model four levers of control dalam meningkatkan kinerja karyawan divisi keuangan PT Pelabuhan Indonesia (Persero) Regional 4 Bitung
Authors: Baramuli Jesicca Leonita , Manossoh Hendrik , Pinatik Sherly 
Published: December 2023

Four Levers of Control is a concept that focuses on achieving strategies in the management control system using four frameworks consisting of belief systems, boundary systems, diagnostic control systems, and interactive control systems. In facing the changes that occurred at PT Pelabuhan Indonesia (Persero) Regional 4 Bitung after the merger, an adequate control system is needed to control the performance of employees. This study aims to determine how the application of the four levers of control in improving the performance of employees of the finance division of PT Pelabuhan Indonesia (Persero) Regional 4 Bitung. The research method used in this research is a qualitative method with a descriptive approach and the data obtained comes from interviews and documentation. The results showed that the application of the four levers of control has been running quite well because it has fulfilled the four frameworks.
Implementasi Siklus Akuntansi Melalui Pengelolaan Bank Sampah di Desa Pahlawan Kecamatan Tanjung Tiram Kabupaten Batu Bara
Authors: Saraswati Dwi , Harahap Ardhansyah Putra 
Published: December 2023

Pengabdian masyarakat merupakan salah satu kewajiban dari Tri Dharma Perguruan Tinggi yang harus dilakukan. Pada Program Bina Desa, tim pengabdi memilih Desa Pahlawan sebagai objek pengabdian yang layak sebagai wujud pembinaan bagi Desa yang mandiri. Permasalahan sampah yang kompleks di Desa Pahlawan menjadikan pengabdian ini sebagai prioritas untuk ditangani pada Program Bina Desa Universitas Pembangunan Pancabudi. Tujuan pengabdian masyarakat ini untuk mengurangi permasalahan dalam pengelolaan sampah dengan terbentuknya Bank Sampah di Desa Pahlawan yang pada akhirnya diharapkan dapat menjadi alternative solusi dari permasalahan yang ada, hingga nantinya juga mampu meningkatkan pendapatan masyarakat desa maupun pendapatan asli desa, menjadikan Desa Pahlawan menjadi Desa yang mandiri dan tangguh. Hasil yang dicapai dari kegiatan ini adalah terbentuknya peraturan desa tentang pembentukan Bank Sampah di Desa Pahlawan, terbentuknya badan usaha desa tentang Bank Sampah, peningkatan pemahaman masyarakat Desa Pahlawan dalam mengolah sampah daur ulang melalui Bank Sampah, peningkatan pengetahuan pengelola Bank Sampah dalam menerapkan siklus akuntansi pada Bank Sampah . Metode yang digunakan dimulai dari 1) Fokus Group Diskusi (FGD) pendampingan dalam pembentukan Peraturan Desa tentang Bank Sampah Desa Pahlawan, 2) pelatihan bagi Pemerintah Desa dan Pengelola Bank Sampah Desa Pahlawan, 3) sosialisasi kepada masyarakat desa tentang pengelolaan sampah melalui Bank Sampah Desa Pahlawan, lalu terakhir dilakukan evaluasi dengan memberikan kuesioner dan menempatkan mahasiswa untuk program magang desa dalam rangka pendampingan maupun memetakan potensi dan masalah yang yang muncul serta solusi dan alternatifnya.
PENYULUHAN HUKUM TENTANG PENCEGAHAN PERKAWINAN DINI PADA SISWA SMA
Authors: Manik Herlina , Oktaviarni Firya , Windarto  , Hartati Dwi Surya , Suhermi  
Published: December 2023

Pernikahan seringkali dianggap sebagai perayaan dan juga sebagai tonggak sejarah dalam kehidupan manusia dewasa di seluruh dunia. Mengingat pernikahan sebagai tonggak sejarah dalam kehidupan manusia, pemerintah telah mengeluarkan usia dewasa pernikahan atau Marriage Age Maturity (MAM) pada tahun 2006. Undang- Undang (UU) Nomor 16 Tahun 2019 tentang Perubahan Atas Undang-Undang Nomor 1 Tahun 2014 tentang Perkawinan menyebutkan, “pernikahan hanya diizinkan jika pihak pria dan wanita sudah mencapai umur 19 tahun”. Mengingat salah satu tugas perkembangan individu dewasa awal dengan rentang usia 19-25 tahun adalah menikah dan menjadi orangtua. Dampak yang timbul dari perkawinan dini yang berkaitan kesehatan dan kesejahteraan telah diakui secara luas. Tetapi pada kenyataannya, perkawinan dini tetap dilakukan dengan meminta dispensasi perkawinan dari pengadilan agama. Di Indonesia sendiri tercatat sebanyak 50.673 dispensasi perkawinan yang diputus pada 2022. Untuk mencegah peningkatan angka perkawinan dini ada lima (5) rekomendasi untuk menjamin percepatan pengurangan angka perkawinan dini.
On the field with social science and humanities participatory research
Authors: Achenbach Kelly , Smaniotto Alessia 
Published: December 2023

Citizen science is a well-established domain in many scientific disciplines. Far less is known about the practices of citizen science in the social sciences and humanities. The COESO project is fostering and highlighting citizen science practices in the social sciences and humanities. Ten European-based case studies – ”pilots” – reporting on specific challenges have fed the COESO project: five of them began at the beginning of the project in January 2021, while the other five were chosen through an Open Call process in early 2022. Each pilot presents a distinct type and model of collaboration between different kinds of stakeholders, addressing specific societal issues. This diversity has contributed to generating knowledge on challenges and innovative knowledge sharing practices found within participatory practices in the social sciences and humanities research fields. The project promotes developing synergies between practices found within various social sciences and humanities disciplines, including sociology, anthropology, political science, and the arts, with practices employed by non-academic professionals working on societal issues. The 10 pilots provide a platform for collaboration between researchers, practitioners, and citizens, allowing for the co-creation of new knowledge and innovative solutions to pressing societal challenges.
The aim of this poster is to show the different engagement strategies co-developed with researchers and community members to involve active citizen participation in the research, as well as the actions and creative outputs carried out to raise awareness of the projects and maintain the interest of participants. From initial stakeholder mapping, information management, data collection and storage to communication and dissemination of results, each pilot has deployed a unique engagement strategy, making COESO an excellent repository of information on the different ways of fostering community engagement with citizen science through social science and humanities initiatives. By showcasing the diversity and potential of these pilots, this poster invites further exploration and collaboration in the exciting and evolving domain of citizen science in the SSH.
Factors Associated with Febrile Treatment-Seeking Behaviour among Expectant Mothers in Ssekanyonyi, Uganda
Authors: Uniah Nanjobe , Ddamulira Christopher , Kizza Stephen S. , Sserwanga Lawlence , Mutekanga David R. 
Published: December 2023

Background: Malaria fever is a serious health problem that contributes greatly to morbidity and mortality in Uganda. In Mityana District where 4 in 10 pregnancy deaths are malaria related mothers who do not seek treatment in health facilities when they experience febrile illnesses. Therefore, a study was undertaken to identify factors associated with treatment-seeking behavior among pregnant women suffering from febrile illnesses suspected to be malaria in Ssekanyonyi Sub-County in Mityana District, Uganda.
Methods: A cross-sectional study in which questionnaires and key informant guides were administered to 198 expectant mothers to generate data on their socio-demographics and treatment seeking behaviour. SPSS software version 20.0 was used for data analysis and a Logistic Regression model was fitted to identify factors that independently influenced their health-seeking behavior.
Results: Out of the198 expectant mothers enrolled in the study, 42.9% were aged 15-25 years, 73.7% had achieved Secondary education, and 46.5% were married. The treatment-seeking behavior was found to be standing at only 56.6%. Among the different factors studied, health education on malaria (AOR = 3.68, P = 0.000), the attitude of midwives (AOR = 1.45, P = 0.003), patient care (AOR = 0.33, P = 0.030), and attitude of the pregnant mother (AOR = 5.38, P = 0.000) were found to be statistically significantly associated with treatment-seeking behavior among pregnant mothers with febrile illnesses.
Conclusion: The study concludes that health education on malaria, attitude of midwives and pregnant mothers are the most important in positively affecting treatment seeking behavior among pregnant mothers with febrile illnesses.
Recommendations: Health education on malaria, attitude of midwives, patient care and attitude of pregnant mothers need to be given attention in a bid to reduce febrile illnesses. The Ministry of Health and other responsible stakeholders need to reinforce awareness programs on health education among women of reproductive age about the danger of febrile illnesses during pregnancy and also help midwives address issues related to their attitude towards pregnant mothers
Photodynamic Therapy in Candida spp. and Epithelial Cell Cultures: An In vitro Study
Authors: Marinho Sandra Aparecida , Teixeira Alice Becker , Cazanova Ricardo Flores , Oliveira Sílvia Dias de , Machado Denise Cantarelli , Cherubini Karen 
Published: December 2023

Aims: The objective of this study was to determinate the photodynamic effect using methylene blue and diode laser on Candida spp. and epithelial cells in vitro.
Study Design: An in vitro study was carried on using cultures of Candida spp. and HEp-2 cells.
Place and Duration of Study: This study was developed at the School of Biosciences of the Department of Microbiologic Sciences and at the Laboratory of Pneumology of the Biomedical Research Institute at São Lucas Hospital, both at the Pontifical Catholic University of Rio Grande do Sul, located in Porto Alegre, Brazil, between January and December.
Methodology: Cultures of Candida spp. and HEp-2 cells were submitted to aPDT with methylene blue (100 μg/mL) and indium-gallium-aluminum-phosphide (InGaAlP) diode laser at 100 J/cm2, 270 J/cm2 and 450 J/cm2.
Results: All of these three doses caused significant inactivation of Candida spp. (P<0.05). At 450 J/cm2, the viability of Candida spp., based on colony forming units (CFUs), was reduced by 72.42%, followed by lesser effects with 270 J/cm2 and 100 J/cm2, 45.87% and 22.83%, respectively. PDT decreased CFUs by 50.44% in C. albicans, while other Candida species showed a 41.18% decline in CFUs (P<0.05). With regard to the average effect of the three doses tested in PDT group, HEp-2 cell viability, based on trypan blue exclusion, declined to 70.81%, which was significantly lower than that observed in the control group (86.21%).
Conclusion: Methylene blue plus laser exposure (100 J/cm2, 270 J/cm2 and 450 J/cm2) caused significant inactivation of Candida spp. Photodynamic inactivation of the epithelial cells based on cell viability was 2.24-fold lower than the inactivation of Candida spp., which suggests a safety margin for in vivo application.
Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis
Authors: Miller Jena L. , Baschat Ahmet A. , Rosner Mara , Blumenfeld Yair J. , Moldenhauer Julie S. , Johnson Anthony , Schenone Mauro H. , Zaretsky Michael V. , Chmait Ramen H. , Gonzalez Juan M. , Miller Russell S. , Moon-Grady Anita J. , Bendel-Stenzel Ellen , Keiser Amaris M. , Avadhani Radhika , Jelin Angie C. , Davis Jonathan M. , Warren Daniel S. , Hanley Daniel F. , Watkins Joslynn A. , Samuels Joshua , Sugarman Jeremy , Atkinson Meredith A. 
Published: December 2023

ImportanceEarly anhydramnios during pregnancy, resulting from fetal bilateral renal agenesis, causes lethal pulmonary hypoplasia in neonates. Restoring amniotic fluid via serial amnioinfusions may promote lung development, enabling survival.ObjectiveTo assess neonatal outcomes of serial amnioinfusions initiated before 26 weeks’ gestation to mitigate lethal pulmonary hypoplasia.Design, Setting, and ParticipantsProspective, nonrandomized clinical trial conducted at 9 US fetal therapy centers between December 2018 and July 2022. Outcomes are reported for 21 maternal-fetal pairs with confirmed anhydramnios due to isolated fetal bilateral renal agenesis without other identified congenital anomalies.ExposureEnrolled participants initiated ultrasound-guided percutaneous amnioinfusions of isotonic fluid before 26 weeks’ gestation, with frequency of infusions individualized to maintain normal amniotic fluid levels for gestational age.Main Outcomes and MeasuresThe primary end point was postnatal infant survival to 14 days of life or longer with dialysis access placement.ResultsThe trial was stopped early based on an interim analysis of 18 maternal-fetal pairs given concern about neonatal morbidity and mortality beyond the primary end point despite demonstration of the efficacy of the intervention. There were 17 live births (94%), with a median gestational age at delivery of 32 weeks, 4 days (IQR, 32-34 weeks). All participants delivered prior to 37 weeks’ gestation. The primary outcome was achieved in 14 (82%) of 17 live-born infants (95% CI, 44%-99%). Factors associated with survival to the primary outcome included a higher number of amnioinfusions (P = .01), gestational age greater than 32 weeks (P = .005), and higher birth weight (P = .03). Only 6 (35%) of the 17 neonates born alive survived to hospital discharge while receiving peritoneal dialysis at a median age of 24 weeks of life (range, 12-32 weeks).Conclusions and RelevanceSerial amnioinfusions mitigated lethal pulmonary hypoplasia but were associated with preterm delivery. The lower rate of survival to discharge highlights the additional mortality burden independent of lung function. Additional long-term data are needed to fully characterize the outcomes in surviving neonates and assess the morbidity and mortality burden.Trial RegistrationClinicalTrials.gov Identifier: NCT03101891
Unveiling Challenges and Opportunities in Silicon‐Based All‐Solid‐State Batteries: Thin‐Film Bonding with Mismatch Strain
Authors: Zhao Mingcai , Zhang Juan , Costa Carlos M. , Lanceros‐Méndez Senentxu , Zhang Qi , Wang Wei 
Published: December 2023

AbstractLi‐metal and silicon are potential anode materials in all‐solid‐state Li‐ion batteries (ASSBs) due to high specific capacity. However, both materials form gaps at the interface with solid electrolytes (SEs) during charging/discharging, resulting in increased impedance and uneven current density distribution. In this perspective, the different mechanisms of formation of these gaps are elaborated in detail. For Li‐metal anodes, Li‐ions are repeatedly stripped and unevenly deposited on the surface, leading to gaps and Li dendrite formation, which is an unavoidable electrochemical behavior. For Si‐based anodes, Li‐ions inserting/extracting within the Si‐based electrode causes volume changes and a local separation from the SE, which is a mechanical behavior and avoidable by mitigating the strain mismatch of thin‐film bonding between anode and SE. Si electro–chemical–mechanical behaviors are also described and strategies recommended to synergistically decrease Si‐based electrode strain, including Si materials, Si‐based composites, and electrodes. Last, it is suggested to choose a composite polymer–inorganic SE with favorable elastic properties and high ionic conductivity and form it directly on the Si‐based electrode, beneficial for increasing SE strain to accommodate stack pressure and the stability of the interface. Thus, this perspective sheds light on the development and application of Si‐based ASSBs.
Bioinspired Lipoproteins of Furoxans–Gemcitabine Preferentially Targets Glioblastoma and Overcomes Radiotherapy Resistance
Authors: Sun Maoyuan , Xie Honglei , Zhang Wenli , Li Xianlu , Jiang Zhan , Liang Yiyu , Zhao Guanjian , Huang Ning , Mao Jinning , Liu Guodong , Zhang Zhiwen 
Published: December 2023

AbstractRadiotherapy (RT) resistance is an enormous challenge in glioblastoma multiforme (GBM) treatment, which is largely associated with DNA repair, poor distribution of reactive radicals in tumors, and limited delivery of radiosensitizers to the tumor sites. Inspired by the aberrant upregulation of RAD51 (a critical protein of DNA repair), scavenger receptor B type 1 (SR‐B1), and C‐C motif chemokine ligand 5 (CCL5) in GBM patients, a reduction‐sensitive nitric oxide (NO) donor conjugate of gemcitabine (RAD51 inhibitor) (NG) is synthesized as radio‐sensitizer and a CCL5 peptide‐modified bioinspired lipoprotein system of NG (C‐LNG) is rationally designed, aiming to preferentially target the tumor sites and overcome the RT resistance. C‐LNG can preferentially accumulate at the orthotopic GBM tumor sites with considerable intratumor permeation, responsively release the gemcitabine and NO, and then generate abundant peroxynitrite (ONOO−) upon X‐ray radiation, thereby producing a 99.64% inhibition of tumor growth and a 71.44% survival rate at 120 days in GL261‐induced orthotopic GBM tumor model. Therefore, the rationally designed bioinspired lipoprotein of NG provides an essential strategy to target GBM and overcome RT resistance.
Non‐enzymatic electrochemical biosensor based on MgO@rGO‐MoS2 nanohybrid for phenolic compounds detection
Authors: Verma Sakshi , Pandey Chandra Mouli , Kumar Devendra 
Published: December 2023

In the present work, efforts have been made to fabricate a non‐enzymatic electrochemical biosensor based on MgO nanoparticles modified graphene oxide‐molybdenum disulfide (MgO@rGO‐MoS2) nanohybrid for ultra‐sensitive detection of water‐polluting dihydroxy benzene compound. The one‐pot hydrothermal method has been used to synthesize MgO@rGO‐MoS2 nanohybrid followed by electrophoretic deposition of the nanohybrid onto ITO‐coated glass substrate. The excellent conducting and catalytic ability of MoS2 and MgO facilitates the superior electroanalytical ability of fabricated electrodes, as revealed by the electrochemical studies, whereas the non‐enzymatic approach boosts the stability and sensitivity of the transducing matrix. The fabricated biosensor exhibits linear response in the 0.1 to 200.0 μM concentration range for hydroquinone (Hqn) with a detection limit of 0.086 μM and 0.04 μA μM−1 cm−2 sensitivity. The validation of the biosensor with tap and running river water shows an outstanding recovery rate.
Multi‐featured epoxy composites filled with surface‐modified PTFE powders treated by Na‐naphthalenide system
Authors: Akin Emre , Çakir Mustafa , Demirer Halil 
Published: December 2023

AbstractThis study aimed to produce new multi‐featured epoxy composites that are advanced in terms of mechanical properties, wear and impact resistance, and glass transition and heat deflection temperatures. Epoxy composites filled with chemically surface‐treated poly (tetrafluoroethylene) (PTFE) powders at various ratios were prepared to obtain these improved properties. The chemical treatment was carried out via a Na‐naphthalenide system. After this treatment, the x‐ray photoelectron spectroscopy results presented the existence of functional groups such as OH, carbonyl groups, and CC unsaturation points on the surface of the PTFE powders. On the PTFE surfaces, while the atomic ratios of carbon and oxygen were substantially increased, the fluorine ratio presented a significant decrease after the chemical treatment. However, the wear rates of the novel composites were highly advanced despite this large decrease in the fluorine ratio on the surface of the PTFE powders. Moreover, functional groups such as OH, carbonyl groups, and CC unsaturation points and spongelike or network structures on the PTFE surfaces provided the opportunity to obtain strong adhesion and interfacial bonding between the surface‐modified PTFE powders and the matrix. Strength and modulus values showed substantial enhancement besides the IZOD impact resistance. All glass transition and heat deflection temperatures were also substantially improved.
Preparation and characterization of transparent polyetherketone
Authors: Cheng Bin , Zhuang Kaiwen , Liu Na , Guo Yilin , Chen Jiangxi , He Guomei 
Published: December 2023

AbstractTransparent polymer with excellent heat resistance and mechanical properties play an important role in many fields. However, transparent polyetheretherketones films are rarely reported, probably due to their high crystallinity. In this work, a transparent polymer polyetherketone was prepared from the reaction of 4,4′‐difluorobenzophenone, 2,6‐bis(4‐hydroxybenzylidene) cyclohexanone, and tert‐butylhydroquinone in the presence of K2CO3. This new polymer has excellent thermal stability, high glass transition temperature (Tg = 172°C), good film‐casting property, high transparency, good hydrophobicity, and low saturated water absorption (0.52%). The material has broad application prospects in flexible solar cells, UV protection, and thin insulation materials.
Functionalizing Separator by Coating a Lithiophilic Metal for Dendrite‐Free Anode‐free Lithium Metal Batteries
Authors: Thang Ai Qin , Tso Shuen , Jia Bei‐Er , Tan Xian Yi , Dong Jinfeng , Zhang Mingsheng , Ng Man‐Fai , Yao Gary , Wong Sun Yew , Liu Zhaolin , Yan Qingyu 
Published: December 2023

AbstractA stable anode‐free lithium metal battery (AFLMB) is accomplished by the adoption of a facile fabricated amorphous antimony (Sb)‐coated separator (SbSC). The large specific surface area of the separator elevates lithium (Li)‐Sb alloy kinetic, improving Li wetting ability on pristine copper current collector (Cu). When tested with LiNi0.8Mn0.1Co0.1O2 (NMC811) as cathode, the full cell with SbSC demonstrates low nucleation overpotential with compact, dendrite‐free and homogeneous Li plating, and exhibits a notable lithium inventory retention rate (LIRR) of 99.8 % with capacity retention of 93.6 % after 60 cycles at 0.5 C‐rate. Conversely, full cells containing pristine separator/Cu (i. e., SC) and pristine separator/Sb‐coated current collector (i. e., SSbC) display poor cycling performances with low LIRRs. Density functional theory corroborates the nucleation behaviours observed during in‐situ half‐cell Li deposition. Functionalizing polymeric separator by metallic coating in AFLMB is a novel approach in improving the cycle life of an AFLMB by promoting homogeneous Li plating behavior. This innovative approach exemplifies a promising applicability for uniform Li‐plating behavior to achieve a longer cycle life in AFLMB.