bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of malondialdehyde, hydroxynonenal, isoprostane and 8-hydroxydeoxyguanosine in osteoarthritis patients and healthy controls
Authors: Muzzafar Zoya , Zaidi Mehreen , Shazia Ramzan  , Bilal Neelum , Shakori Tania Ahmad , Hadi Fahim , Maqbool Tahir , Tahir Muhammad , Akhtar Shabana 
Published: October 2023

Abstract
Objective: To study the level of oxidative Stress markers like malondialdehyde, 4 Hydroxynonenal (HNE), Isoprostane and 8 hydroxyguanosine was measured in the serum, saliva and urine of the patients suffering from osteoarthritis.
Methods: In this study, oxidative stress markers in the body fluids of Osteoarthritic( OA) patients were compared with the control groups. The level of stress markers were determined by commercially available quantitative ELISA kits.
Result: Our findings indicate that the highest levels of these oxidative stress markers were detected in serum followed by urine. The saliva overall presented less levels of oxidative stress markers in individuals with and without OA. In addition to this detection of MDA in serum sample was found to be the most important tool in the detection of OA.
Conclusion: the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.
Keywords: Osteoarthritis, MDA, HNE, 8-Hydroxyguanosine, Isoprostane, lipidperoxidation
Deteksi Dini Kesehatan Jiwa di Wilayah Kerja Puskesmas se- Kabupaten Bondowoso
Authors: Susilowati Susilowati 
Published: October 2023

Dewasa ini,orang dengan gangguan jiwa ( ODGJ ) seperti fenomena gunung es,artinya tidak tampak terlalu mendetail dan mendalam. Jawa Timur masuk dalam propinsi dengan angka ODGJ terbanyak nomor 2 di Indonesia( Dinas Kesehatan Propinsi Jawa Timur,2013 ), maka deteksi dini kesehatan jiwa di masyarakat khususnya pada ODGJ di Kabupaten Bondowoso perlu dilakukan . Program Studi D3 Keperawatan Universitas Bondowoso bekerjasama dengan Dinas Kesehatan Kabupaten Bondowoso melakukan deteksi dini kesehatan jiwa selama 1 bulan.Metoda yang digunakan melalui data dari Puskesmas dan dari Kepala Desa,dilanjutkan deteksi dini langsung ke masyarakat . Jumlah sasaran adalah seluruh Puskesmas di Kabupaten Bondowoso yaitu sebanyak 25 Puskesmas . Hasil Deteksi dini kesehatan jiwa adalah Jumlah ODGJ sebanyak 604 orang dan terbanyak berada di wilayah kerja Puskesmas Wringin yaitu 75 orang ( 12% ) dan setiap wilayah puskesmas terdapat ODGJ . Bedasar hasil deteksi dini kesehatan jiwa, maka perlu program penanganan ODGJ yang komprehensif melalui posyandu kesehatan jiwa di Kabupaten Bondowoso.
The Existence of Govermental and Environmental Uncertainty on Competitive Advantage of Private Universities
Authors: Saring Suhendro 
Published: October 2023

Aims: This study aims to illustrate empirically the impact of governance and environmental uncertainty on the quality of B-accredited private universities and their long-term competitive advantage.
Study Design: The method used in this study used descriptive and causal-explanatory methods to test the research hypothesis.
Place and Duration of Study: All private universities accredited by B in Indonesia.
Methodology: This Research used descriptive and causal-explanatory methods. Data for this research were collected using a questionnaire and supplemented with interviews involving various university leaders. A random sampling technique was utilized to select a sample of 136 B-accredited private universities in Indonesia. The data was analyzed using the Structural Equation Modeling (SEM) approach. The study's findings show that higher education governance has a significant influence on both the quality of higher education and long-term competitive advantage, both directly and indirectly.
Results: In contrast, environmental uncertainty has a major impact on higher education quality but has little effect on long-term competitive advantage. Higher education quality, on the other hand, has a strong beneficial influence on long-term competitive advantage. Furthermore, this research demonstrates that improved quality among B-accredited private institutions boosts their competitive advantage.
Conclusion: This research shows that improving quality among B-accredited private institutions will increase their competitive advantage. Therefore, the results of this investigation provide a valuable contribution in addressing the problem of substandard quality in private universities in Indonesia and expand existing research on environmental governance and communication in university environments.
Fiscal Policy and Inflation in Nigeria
Authors: Udoh Idongesit Edem , Kokoette Ime Uwem 
Published: October 2023

Aims: This study aims to analyze how Nigerian government activities impact inflation, considering the inadequacy of monetary policy. It focuses on recurrent and capital expenditures in various sectors and their influence on inflation, as well as public debt and tax revenue's role in inflation dynamics.
Study Design: The study employed secondary data.
Place and Duration of Study: Data sources include the National Bureau of Statistics (NBS), Central Bank of Nigeria (CBN) statistical bulletin, Debt Management Office (DMO), and World Development Indicators (WDI) spanning from 1986 to 2021
Methodology: The study employs econometric techniques, including unit root tests and Autoregressive Distributive Lag (ARDL) analysis, with Inflation Rate (IFL) as the dependent variable. Independent variables representing fiscal policy include capital expenditure on transfers (CTRA), recurrent expenditure on administration (RADM), recurrent spending on social and community services (RSCS), recurrent expenditure on economic services (RECE), recurrent expenditure on transfers (RTRA), capital expenditure on administration (CADM), capital spending on social and community services (CSCS), capital expenditure on economic services (CECE), government direct and indirect taxes (TAX), government capital expenditure (GCE), government recurrent expenditure (GRE), and external debts (PUD).
Results: Key findings reveal that in the long run, only RADM, RTRA, CADM, CECE, CSCS, GRE, GCE, PUD, and TAX had statistically significant relationships with inflation (IFL). RADM, CECE, CSCS, GCE, PUD, and TAX exhibited negative relationships with IFL, while RTRA, CADM, GRE showed positive relationships. In the short run, RSCS, RTRA, CADM, CECE, CSCS, CTRA, GRE, GCE, and TAX displayed statistical significance. RSCS, RTRA, CADM, and GRE positively correlated with IFL, while CECE, CSCS, CTRA, GCE, and TAX had negative associations.
Conclusion: The study concludes that Nigeria's fiscal policy should prioritize increased government capital spending in economic and social sectors to manage inflation effectively. Additionally, implementing fiscal restraint through higher taxation can help mitigate inflationary pressures.
Empowering Farmers of Himachal Pradesh through E-NAM
Authors: Kiran  , Gupta Disha , Kanawjia Amit , Thakur Bhavna 
Published: October 2023

E-National Agricultural Market (E-NAM) was launched on 14.04.2016 with a vision to bring transparency, uniformity, to realize optimum price of farmers’ produce and to provide a national wide electronic platform for trading of agricultural commodities. It has provided an alternate in form of a national market for marketing of agricultural commodities other than traditional way of marketing.26 wholesale markets of Himachal Pradesh are linked with E-NAM portal. Initially, two mandis namely APMC Dhalli and APMC Solan were chosen as pilot mandis as on 14th April, 2016, subsequently 5 more mandis by September 2016 ,12 mandis by March, 2017and 7 mandis by June 2022 were integrated in phased manner with e-National Agriculture Market Portal. At present, in addition to 26 existing market yards, 12 more market yards are proposed to be brought in the ambit of e-NAM. NAM must ensure farmers get paid on time and in full. e NAM should also ensure that the entire ecosystem including assaying and grading works in tandem to ensure that all-India participation works well in order to get our farmers a remunerative price for their produce.
Optimisation of Seed Priming Techniques in Paddy
Authors: Veerendra M. , Srinivasulu K. , Sreedevi B. , Kumara S. Ratna , Rao V. Srinivasa 
Published: October 2023

Aim: To determine the ideal concentration of each priming agent among several selected concentrations which could produce robust paddy seedlings under laboratory conditions.
Place of Study: The present investigation was carried out at College farm, Agricultural College, Bapatla.
Methodology: Certain seedling vigour traits such as germination percentage, shoot length, root length, seedling length, seedling dry weight, seedling vigour index-I & II were recorded and analysed using crompletely randomized block design (CRD). Best concentration is the one with higher vigour indices.
Result: The results revealed that, 1% Nacl, 40 ppm ascorbic acid, 150 ppm gibberellic acid, 2 % neem leaf extracts, 0.5 & 0.1 % P & Zn were optimum concentrations under each priming technique. When compared among all the techniques, priming with gibberellic acid @ 150 ppm performed better in terms of all the vigour traits.
Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection
Authors: Sunarti Lusia Sri 
Published: October 2023

Aim: to describe the competition between Neisseria gonorrhoeae with the naturally inhabitant of microbial community right at the outer mucosal surface to authorize infection.
Discussion: Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium N. gonorrhea. Official report mention that by the year 2020, there were an estimated 82.4 million new infections among adults globally and poses a risk of onward transmission to sex partners. It surely could affect both men and women; for male, the symptoms are more obvious, but for women it occurs more often without prominent clinical symptoms and usually lead to long-term health problems including pelvic inflammatory disease and infertility. The female reproductive tract with its abundant variety of epithelial cells act as its primary niche where initially it was inhabited by normal microbiota, characterized by a high abundance of Lactobacilli, and uniquely linked to the host’s mucosal immunity and plays a critical role in the regulation of genital inflammation. Unfortunately, the dynamics regarding number and composition of vaginal microbiota has been shown to fluctuate over several internal and external factors, especially due to STI like gonorrhea. Its proposed evolution from an ancestral commensal bacterium, N. gonorrhoeae has retained features that are commonly found among commensal inhabitants, but it has also developed unique features that are crucial to its pathogenesis. The scope of its pathogenesis field elucidate competition, colonization and growth properties as main virulence determinants.
Conclusion: Competition between N. gonorrhoeae and the already exist natural microbiota of the vagina occur initially at the mucosal surface. This gonococcus has several intrinsic factors that can facilitate its competitiveness including adherence, even though not all available adhesion mechanisms are actually used by this organism during the course of infection/colonization of any specific site.
Influence of Weed Control Measures and Nutrient Management on Nutrient Content, Uptake and Nutrient use Efficiency of Fennel Crop (Foeniculum vulgare Mill.)
Authors: Meena Pooja Kumari , Bairwa Ramesh Chand , Yadav Anuradha , Kumawat Sumitra , Meena Puspa , Choudhary Sampat 
Published: October 2023

A research experiment was conducted during the Rabi season of 2021-22 at the College of Agriculture, SKRAU, Bikaner. The objective of the experiment was to evaluate the influence of different nutrient management and weed control treatments on the nutrient content, uptake and nutrient use efficiency of fennel crop. The experiment consisted of sixteen treatment combinations, which included four nutrient management treatments and four weed control measures. The nutrient management treatments included control (no fertilizer applied), 75 % RDF, 100 % RDF and 125 % RDF and four weed control measures- weed free, pendimethalin @ 0.75 kg ha-1 (PE), oxyfluorfen @ 50g ha-1 (POE at 25 DAS) and weedy check. These treatments were replicated three times in a factorial randomized block design (FRBD), ensuring the reliability and accuracy of the results. The weed-free treatment was found to be significantly better in increasing the nitrogen, phosphorus, and potassium content in both the seed and straw of the crop. Additionally, the weed-free treatment also resulted in higher nutrient uptake by the crop compared to the weedy check treatment. Among the nutrient management treatments, the application of 100% RDF showed the most promising results. It improved the nutrient content in both the seed and straw of the crop and recorded the highest nutrient use efficiency. This efficiency was found to be at par with the application of 125% RDF and significantly higher than the remaining treatments. Overall, the experiment demonstrated the importance of weed control and proper nutrient management in enhancing the nutrient content and uptake by the crop. The weed-free treatment and the application of 100% RDF were identified as the most effective strategies in achieving these goals. These findings can be valuable for farmers and agricultural practitioners in optimizing crop productivity and ensuring sustainable agricultural practices.
The Utilization of Response Surface Methodology (RSM) In the Optimization of Diclofenac Sodium (DS) Liposomes Formulate through the Thin Film Hydration (TFH) Technique with Involving Computational Method
Authors: Pal Rahul , Pandey Prachi , Rizwan Mohammad , Koli Manju , Arushi  , Thakur Shiva Kant , Malakar Raj Kumar , Gupta Himangi , Khadam Vinay Kumar Rao , Chawra Himmat Singh 
Published: October 2023

Objectives: The objective of the current studies to enhance the formulation of DS-loaded liposomes through the utilization of Response surface methodology (RSM) and involving the computation approach for their validation.
Methods: The optimization of DS-loaded liposomes was conducted using RSM, focusing of 2 main key parameters including encapsulation efficiency (% EE) and In-vitro drug release (% DR) for 12 hours via involving QbD. To formulate an optimize liposome formulation utilizing a 32 factorial design, with the phospholipid and cholesterol (CH) concentrations being the chosen independent variables. Nine formulations of DS-loaded liposomes were prepared using the TFH technique. The % EE, drug content, and in vitro release studies were assessed utilizing an Ultra Violet (UV)-visible spectrophotometer for λmax-275 nm. The evaluation included zeta potential, vesicle characterization, particle size and polydispersity index (PDI) of the best optimized DS formulation were evaluated. Lastly the involvement of computational tools, such as molecular dynamics simulations docking with COX-2 active site via Y385.
Results: The regression equations using RSM revealed that the phospholipid and CH molar concentration were significant variables in optimizing the percentage of % EE and percentage of drug release (% DR), with estimated coefficient values. The % EE was found to be 83.55±0.29, while the % DR was 71.22±0.34. The assumption of % DR and % EE values showed low % relative errors (PRE) of 0.069% and -0.194% respectively. The result shows that the design-developed model is appropriate for DS formulations and validates the model.
Conclusion: Investigational outcome represents the perceived responses were in related with the desired values and this represents the relationship of the RSM for optimization of % DR and % EE in DS loaded liposomal preparations.
Natranaerovirgaceae
Authors: Sorokin Dimitry Y. , Merkel Alexander Y. 
Published: October 2023

Abstract

Natr.an.aer.o.vir.ga'ce.ae
N.L. fem. n.
Natranaerovirga,
the type genus of the family, ‐
aceae
ending to denote a family; N.L. fem. pl. n
. Natranaerovirgaceae,
the
Natranaerovirga
family.

Firmicutes A / Clostridia / Lachnospirales / Natranaerovirgaceae

The family
Natranaerovirgaceae
includes obligately anaerobic fermentative bacteria from soda lakes. They are highly salt‐tolerant alkaliphiles utilizing carbohydrates as energy and carbon source. The family belongs to the order “Lachnospirales,” class
Clostridia
, and consists of a single genus
Natranaerovirga
. The family‐level status was established by phylogenomic analysis based on the Genome Taxonomy Database classification (GDTB).

DNA G
+
C content (mol%)
: 31.3–32.3 (whole‐genome sequence).

Type genus
:
Natranaerovirga
Sorokin et al. 2012, VL145.
Prochlorococcus
Authors: Zinser Erik R. , Martiny Adam C. 
Published: October 2023

AbstractPro.chlor.o.coc.cus. Gr. prep.pro, before, primitive; Gr. masc. adj. chlôros green; Gr. masc. n.kokkos, grain or kernel; N.L. masc. n.Prochlorococcus, primitive green kernel (cell).Cyanobacteriota / Cyanophyceae / “Synechococcales” / Synechococcaceae / ProchlorococcusThe genusProchlorococcuscurrently includes the speciesProchlorococcus marinus. Cells are oxygenic photoautotrophs that lack phycobilisomes.Prochlorococcusis prototrophic, requiring no organic substrates for growth, although some strains can import several types of organic carbon. Cells do not fix dinitrogen. Cells are small non‐motile cocci that possess no known extracellular appendages. The major core lipids of cell membranes are sulfolipids and glycolipids.Prochlorococcusis strictly marine and numerically dominates the phytoplankton community in the oligotrophic region of the ocean.DNA G + C content (mol%): 31–51.Type species:Prochlorococcus marinusChisholm et al. 1992, VL79.
Erwinia
Authors: Coutinho Teresa A , Shin Gi Yoon 
Published: October 2023

Abstract

er.win'i.a. N.L. fem. n.
Erwinia
, named after Erwin F. Smith.

Proteobacteria / Gammaproteobacteria / Enterobacterales / Erwiniaceae / Erwinia

Cells of the genus
Erwinia
are Gram‐stain‐negative rods, 0.5–1.0 × 1.0–3.0 μm, and occur alone or in pairs, sometimes in chains. Cells are motile by means of peritrichous flagella. They do not produce indole. They are mostly facultatively anaerobic, catalase‐positive, and oxidase‐ and urease‐negative. They utilize
d
‐arabinose, fructose, fumarate, galactose, gluconate, glucose, glycerol, malate, β‐methyl‐glucoside,
N‐
acetyl‐
d
‐glucosamine, ribose, trehalose, and succinate but not benzoate, butanol,
l
‐fucose, glycogen, methanol, oxalate, propionate, or sorbose as the sole carbon sources. The major fatty acids are C
12:0
, C
14:0
, and C
16:0
. The known habitats are plants, where they cause vascular wilts and soft rots. They are also part of the epiphytic flora. They have also been isolated from insects and in one case from human skin.

DNA G + C content (mol%)
: 51.1–56.4%.

Type species
:
Erwinia amylovora
Winslow et al. 1920
AL
(basonym:
Micrococcus amylovorus
Burrill 1882).
Regulating Photocatalytic CO2 Reduction Kinetics through Modification of Surface Coordination Sphere
Authors: Feng Chengyang , Bo Tingting , Maity Partha , Zuo Shouwei , Zhou Wei , Huang Kuo‐Wei , Mohammed Omar F. , Zhang Huabin 
Published: October 2023

AbstractSolar‐driven reduction of CO2 to value‐added products represents a sustainable strategy for mitigating the greenhouse effect and addressing the related green‐energy crisis. Herein, it is demonstrated that modifying the surface coordination sphere can significantly enhance the reaction kinetics and overall efficiency of CO2 reduction. More specifically, the decoration of isolated Mn atoms over the multi‐edged TiO2 nano‐pompons (Mn/TONP) upshifts the d‐band center that allows favorable CO2 adsorption. Ultrafast spectroscopy demonstrates the greatly accelerated charge transfer between photoexcited multi‐edged TONP and the newly implanted Mn reactive centers, supplying long‐lifetime electrons to reduce absorbed CO2 molecules. By integrating adsorption and activation functions into the newly decorated Mn sites, the developed photocatalyst demonstrate impressive capacity for CO2 reduction (80.51 mmol g−1 h−1). The surface modulation strategy at the atomic level not only opens new avenues for regulating the reaction kinetics toward photocatalytic CO2 reduction, but also paves the way for the rational design of highly efficient and selective photocatalysts for clean energy conversion.
In Situ Electrochemically‐Bonded Self‐Adapting Polymeric Interface for Durable Aqueous Zinc Ion Batteries
Authors: Zhang Ying , Zhang Yaxin , Deng Jie , Xue Rongrong , Yang Shanchen , Ma Yue , Wang Zhaohui 
Published: October 2023

AbstractThe implementation of aqueous zinc ion batteries (AZBs) is hindered by the notorious Zn dendrite growth and side reactions on Zn anodes. Herein, a novel strategy is introduced to overcome these hurdles by designing a self‐adapting soft polymeric composite interface (SAP). Unlike conventional methods relying on passive coating process, the approach leverages dynamic in situ electrochemical bonding via Zn─O interactions formed during cycling, ensuring intimate contact between the SAP interface and Zn electrode. The SAP interface boasts a robust network of hydrogen bonding and electrostatic interactions, which not only promotes the desolvation of Zn2+ and the repulsion of SO42−, facilitating uniform and rapid Zn2+ migration while effectively suppressing parasitic reactions; but also exhibits remarkable self‐adapting and self‐healing capabilities, enabling the interface to accommodate volume changes and repair mechanical failures over prolonged cycling. Consequently, highly reversible Zn electrodes are achieved with SAP, showcasing 3300 h at 1 mA cm−2/0.5 mAh cm−2 and 350 h at 20 mA cm−2/10 mAh cm−2 in the symmetric cells. The advantages of the SAP interface are further verified when paired with high mass loading LiMn2O4 cathodes in AZBs. The versatile SAP interface offers insights into advanced interface design for efficient and durable AZBs.
Thrombin and Thrombin‐Incorporated Biomaterials for Disease Treatments
Authors: Zhang Qiong‐Dan , Duan Qiu‐Yi , Tu Jing , Wu Fu‐Gen 
Published: October 2023

AbstractThrombin, a coagulation‐inducing protease, has long been used in the hemostatic field. During the past decades, many other therapeutic uses of thrombin have been developed. For instance, burn treatment, pseudoaneurysm therapy, wound management, and tumor vascular infarction (or tumor vasculature blockade therapy) can all utilize the unique and powerful function of thrombin. Based on their therapeutic effects, many thrombin‐associated products have been certificated by the Food and Drug Administration, including bovine thrombin, human thrombin, recombinant thrombin, fibrin glue, etc. Besides, several thrombin‐based drugs are currently undergoing clinical trials. In this article, the therapeutic uses of thrombin (from the initial hemostasis to the latest cancer therapy), the commercially available drugs associated with thrombin, and the pros and cons of thrombin‐based therapeutics (e.g., adverse immune responses related to bovine thrombin, thromboinflammation, and vasculogenic “rebounds”) are summarized. Further, the current challenges and possible future research directions of thrombin‐incorporated biomaterials and therapies are discussed. It is hoped that this review may provide a valuable reference for researchers in this field and help them to design safer and more effective thrombin‐based drugs for fighting against various intractable diseases.