bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional differences in clinical phenotype of axial spondyloarthritis: results from the International Map of Axial Spondyloarthritis (IMAS)
Authors: Poddubnyy Denis , Sommerfleck Fernando , Navarro-Compán Victoria , Bundy Christine , Makri Souzi , Akerkar Shashank , Wermskog Lillann , Karam Elie , Correa-Fernández José , Siddiqui Asif , Garrido-Cumbrera Marco 
Published: December 2023

Abstract

Objectives
To explore differences in axial spondyloarthritis (axSpA) clinical phenotype around the world in a large sample of patients included in the International Map of Axial Spondyloarthritis (IMAS).

Method
IMAS was a cross-sectional online survey (2017–2022) of 5557 unselected axSpA patients from 27 countries. We analysed across five geographic regions the age at symptom onset, diagnostic delay, gender, HLA-B27, family history, extra-musculoskeletal manifestations, presence of comorbidities, disease activity (BASDAI), level of spinal stiffness and treatments.

Results
Of 5557 IMAS participants, 3493 were from Europe, 770 from North America, 600 from Asia, 548 from Latin America and 146 from South Africa. Age at symptom onset ranged between 25 and 30 years and was higher in Latin America. Diagnostic delay was longest in South Africa and lowest in Asia. The lowest HLA-B27 positivity was observed in Latin America and the highest in Asia. Extra-musculoskeletal manifestations were the lowest in Europe. Mean disease activity (BASDAI) was 5.4, with highest values in South Africa and lowest in Asia. Most of the patients had used NSAIDs for their condition and less than half had ever taken conventional synthetic DMARDS; both were more frequent in Latin America and South Africa. Almost half of the patients had ever taken biologic DMARDs, more frequent use being in the Americas.

Conclusion
There is great heterogeneity of axSpA clinical phenotype presentation around the world. AxSpA manifests differently in different regions, so further understanding of these differences of phenotypes is needed to achieve early diagnosis and initiation of optimal disease treatment in axSpA in the different regions.
Precision measurements of U3O8 and Ra(eU3O8) in uraniferous samples by gamma ray spectrometry using two HPGe coaxial P-type detectors (GCD30180 & GC5019 models)—a comparative study
Authors: Shankar V Madhavi , Rupa N , Rao R Bala Bhaskara 
Published: December 2023

Abstract
The precision measurements of U3O8 and Ra(eU3O8) concentrations were evaluated in 23 geological rock samples by high resolution gamma ray spectrometry (HPGe) using two P-type HPGe detectors. The use of Detector 2 (DET2) (GC5019) has increased the sensitivity by a factor of two for both the measurements in comparison to Detector 1 (DET1) (GCD30180). The Minimum Detection Limit (MDL) and Limit of quantification (LOQ) for U3O8 in DET2 has increased significantly because of negligible background counts in 1.001 MeV ϒ energy peak (0.838% gamma yield). The MDL for Ra(eU3O8) measured by 0.609 MeV and 1.760 MeV has not improved significantly due to the high background counts in these energies whereas LOQ has improved appreciably. DET 2 has given higher level of confidence in reporting the analytical results with acceptable repeatability due to the decrease in uncertainty of the measurements.
Estimation of radioactivity in soil and drinking water samples from Northern Gulbarga District of Karnataka
Authors: Rajesh Mugalgaon Archana , Mugalgaon Rajesh Siddanna , Kerur Basavaraj Rachappa , Rangaswamy Devagondanahalli Rangegowda 
Published: December 2023

Abstract
The gamma activity of the radionuclides238U, 232Th and 40K were measured in surface soil samples collected from 40 villages of Aland, Afzalpur, Ganaghapur and Kamalapur talukas of Northern Gulbarga district, Karnataka. The gamma activity of natural radionuclides were measured using 4" × 4" NaI (Tl) scintillation detector, the spectrum was analysed using a PC based 1 k MCA (winTMCA 32 scinti SPEC) and the 222Rn activity concentrations in drinking water were determined by the Emanometry method. The activity of 238U, 232Th and 40K was found to be in the range from 14.3 ± 0.3 to 64.5 ± 6.1, 15.4 ± 0.2 to 95.0 ± 4.1 and 21 ± 06 to 323 ± 09 Bq kg−1, respectively. Outdoor AED from 0.023 to 0.07 mSv y−1 and all the radiological hazards indices were well within the safe limit. The 222Rn activity in ground water is found to vary from 1.11 to 66.6 Bq l−1. The total annual effective doses due to 222Rn inhalation and ingestion range from 3.02 to 181.81 μSv y−1, respectively, with an average value of 77.18 μSv y−1.
Thermoluminescence properties of copper-doped TiO2 nanoparticles synthesised using co-precipitation method for high-dose gamma dosimetry
Authors: Sharmila Kankanady , Prabhu Nimitha S , Kamath Sudha D , Kamat Vinayak A , Swaroop Kumaraswamy , Somashekarappa Hiriyur M 
Published: December 2023

Abstract
In this work, copper (Cu)-doped titanium dioxide (TiO2) nanoparticles were prepared by co-precipitation. For studying the morphological properties, the copper doped titanium dioxide (TiO2:Cu) nanocrystalline structures were characterised through powder X-ray diffraction and field emission scanning electron microscopy. The prepared TiO2:Cu nanoparticles were annealed at two temperatures, namely, copper doped titanium dioxide annealed at 723 K temperayure (TC1) and copper doped titanium dioxide annealed at 1073 K temperayure (TC2). The annealed samples were exposed to gamma radiation of 10-Gy-to-25-kGy doses. Thermoluminescence and dosimetric properties were evaluated using a thermoluminescent dosemeter reader. The glow curves of the TiO2:Cu nanoparticles were analysed. The thermoluminescence (TL) response of samples exhibited good linearity between 100 Gy and 10 kGy with high sensitivity of 1755.25 (TC1) and 5587.06 (TC2) counts g−1Gy−1 and a minimum detectable dose of 2.9666 Gy (TC1) and 0.4892 Gy (TC2). The fading of signals was observed by 12% for TC1 and 10% for TC2 samples after a week of storage.
A review of 20 years publication in the field of radiation protection in diagnostic radiology in Iran
Authors: Zarghani Hassan , Pandesh Sajjad , Jabbari Masoud 
Published: December 2023

Abstract
In recent years, knowing the risks of stochastic effects of radiation, patient dose in diagnostic radiology is taken in to consideration extensively. Many countries and international organization, including International Commission on Radiological Protection, use quantities such as dose area product, entrance surface dose, etc. in radiological investigations, which serve as a guide for patient dose reduction. The concept of diagnostic reference level (DRL) is used to optimizing the dose of patients undergoing diagnostic radiology examinations. The present study aimed to review the studies on the DRLs in Iran. This study was conducted to review the status of patient dose in diagnostic radiology in Iran. A comprehensive literature search was performed without time constraints in the popular databases such as Google Scholar, Medline, Embase, PubMed, Irandoc, Iran Medex, Magiran and Scientific Information Database under the key words ‘Entrance Surface Dose’, ‘dose area product, ‘diagnostic reference level’ and ‘DRL’ in Iran. Data on the radiation dose to patients has demonstrated further reductions in patient doses in the Iran. Considering advanced techniques and dose reduction methodologies complicates comparability between studies. Joint efforts of experts in the field of radiological protection and medical imaging and training program are necessary for achieving an acceptable condition.
Development and characterisation of a plastic scintillator dosemeter in high-energy photon beams
Authors: Wahabi Janatul M , Ung N M , Mahdiraji Ghafour A , Wong Jeannie H D 
Published: December 2023

Abstract
The radioluminescent (RL) dosemeter is excellent for real-time radiation measurement and can be used in various applications. A plastic scintillator is often the choice sensor because of its size and tissue equivalency. This study aims to characterise a novel plastic scintillator irradiated with high-energy photon beams. An RL dosimetry system was developed using the plastic scintillator. The RL dosimetry system was irradiated using a linear accelerator to characterise the dose linearity, dose rate, energy dependency and depth dose. The developed system showed a linear response toward the dose and dose rate. An energy dependency factor of 1.06 was observed. Depth dose measurement showed a mean deviation of 1.21% from the treatment planning system. The response and characteristics of the plastic scintillator show that it may be used as an alternative in an RL dosimetry system.
Nonstructural carbohydrates explain post-fire tree mortality and recovery patterns
Authors: Reed Charlotte C , Hood Sharon M 
Published: December 2023

Abstract
Trees use nonstructural carbohydrates (NSCs) to support many functions, including recovery from disturbances. However, NSC’s importance for recovery following fire and whether NSC depletion contributes to post-fire delayed mortality are largely unknown. We investigated how fire affects NSCs based on fire-caused injury from a prescribed fire in a young Pinus ponderosa (Lawson & C. Lawson) stand. We assessed crown injury (needle scorch and bud kill) and measured NSCs of needles and inner bark (i.e., secondary phloem) of branches and main stems of trees subject to fire and at an adjacent unburned site. We measured NSCs pre-fire and at six timesteps post-fire (4 days–16 months). While all trees initially survived the fire, NSC concentrations declined quickly in burned trees relative to unburned controls over the same post-fire period. This decline was strongest for trees that eventually died, but those that survived recovered to unburned levels within 14 months post-fire. Two months post-fire, the relationship between crown scorch and NSCs of the main stem inner bark was strongly negative (Adj-R2 = 0.83). Our results support the importance of NSCs for tree survival and recovery post-fire and suggest that post-fire NSC depletion is in part related to reduced photosynthetic leaf area that subsequently limits carbohydrate availability for maintaining tree function. Crown scorch is a commonly measured metric of tree-level fire severity and is often linked to post-fire tree outcome (i.e., recovery or mortality). Thus, our finding that NSC depletion may be the mechanistic link between the fire-caused injury and tree outcome will help improve models of post-fire tree mortality and forest recovery.
A cytokinin response factor PtCRF1 is involved in the regulation of wood formation in poplar
Authors: Fu Xiaokang , Xin Yufeng , Shen Gui , Luo Keming , Xu Changzheng , Wu Nengbiao 
Published: December 2023

AbstractWood formation is a complex developmental process under the control of multiple levels of regulatory transcriptional network and hormone signals in trees. It is well known that cytokinin (CK) signaling plays an important role in maintaining the activity of the vascular cambium. The CK response factors (CRFs) encoding a subgroup of AP2 transcription factors have been identified to mediate the CK-dependent regulation in different plant developmental processes. However, the functions of CRFs in wood development remain unclear. Here, we characterized the function of PtCRF1, a CRF transcription factor isolated from poplar, in the process of wood formation. The PtCRF1 is preferentially expressed in secondary vasculature, especially in vascular cambium and secondary phloem, and encodes a transcriptional activator. Overexpression of PtCRF1 in transgenic poplar plants led to a significant reduction in the cell layer number of vascular cambium. The development of wood tissue was largely promoted in the PtCRF1-overexpressing lines, while it was significantly compromised in the CRISPR/Cas9-generated double mutant plants of PtCRF1 and its closest homolog PtCRF2. The RNA sequencing (RNA-seq) and quantitative reverse transcription PCR (RT-qPCR) analyses showed that PtCRF1 repressed the expression of the typical CK-responsive genes. Furthermore, bimolecular fluorescence complementation assays revealed that PtCRF1 competitively inhibits the direct interactions between histidine phosphotransfer proteins and type-B response regulator by binding to PtHP protein. Collectively, these results indicate that PtCRF1 negatively regulates CK signaling and is required for woody cell differentiation in poplar.
An atypical case of acute transverse myelitis following COVID-19 infection
Authors: Spillman Amanda Mallory 
Published: December 2023

ABSTRACT
Acute transverse myelitis is a rare condition that can follow a viral infection. At least 43 cases of COVID-19 associated with acute transverse myelitis have been presented in the literature. This case review highlights one such case in a young man. Although rare, acute transverse myelitis following COVID-19 can cause significant disability for patients. Clinicians must be equipped and encouraged to report and study cases of neurologic complications following COVID-19 infection to develop further treatment and cure.
Shedding new light on actinic keratoses and squamous cell carcinoma in situ
Authors: Khachemoune Amor , Juan Hui Yu , Singh Rohan 
Published: December 2023

ABSTRACT
Cutaneous squamous cell carcinoma can arise from various premalignant lesions such as actinic keratosis, Bowen disease, and premalignant genital squamous cell lesions. Identification and treatment can prevent malignant transformation and death. This article describes the causes, epidemiology, and characteristics of suspicious premalignant squamous cell lesions so that clinicians can identify these lesions and refer patients for specialist treatment as appropriate.
Family Management Skills Reported by Parents of Preterm Infants in the NICU Using the Self- and Family Management Framework (SFMF)
Authors: Weber Ashley , Bakas Tamilyn , Schulman-Green Dena , Voos Kristin C. , Rice Jared B. , Bailey Richard , Reigel Alexandra , Oudat Qutaibah , Holmes Maya , Tubbs-Cooley Heather L. , Kaplan Heather C. 
Published: December 2023

Background:
Across the globe, family-integrated care (FICare) has become an evidence-based standard in which parents deliver the majority of infant care in the neonatal intensive care unit (NICU). Because of extensive barriers to parent presence, adaptations to FICare may be required for successful implementation. Family management theory may provide structure to the Parent Education of FICare and help nurses guide parents’ skill development as equal care members.

Purpose:
To identify family management skills employed by NICU parents using the Self- and Family Management Framework (SFMF).

Methods:
We conducted secondary analyses of qualitative interview data from NICU parents (n = 17) who shared their experiences of using family management skills to care for their infant. We categorized skills according to 3 main self- and family management processes: Focusing on Infant Illness Needs; Activating Resources; and Living With Infant Illness.

Results:
Parents reported several family management skills currently identified in the SFMF, as well as new skills such as conflict management, power brokerage, and addressing resources related to social determinants of health. Parent activation of resources was critical to sustaining parent focus on the infant's illness needs.

Implications for Practice and Research:
By teaching skills that parents reported as helping them manage infant care, neonatal nurses may better facilitate parent integration into the care team. Future researchers can incorporate the skills identified in this study into the design of family management interventions that facilitate FICare implementation in the United States.
Fetoscopic Endoluminal Tracheal Occlusion for Severe, Left-Sided Congenital Diaphragmatic Hernia
Authors: Bergh Eric , Baschat Ahmet A. , Cortes Magdalena Sanz , Hedrick Holly L. , Ryan Greg , Lim Foong-Yen , Zaretsky Michael V. , Schenone Mauro H. , Crombleholme Timothy M. , Ruano Rodrigo , Gosnell Kristen A. , Johnson Anthony 
Published: December 2023

OBJECTIVE:
To report the outcomes of fetoscopic endoluminal tracheal occlusion in a multicenter North American cohort of patients with isolated, left-sided congenital diaphragmatic hernia (CDH) and to compare neonatal mortality and morbidity in patients with severe left-sided congenital diaphragmatic hernia who underwent fetoscopic endoluminal tracheal occlusion with those expectantly managed.

METHODS:
We analyzed data from 10 centers in the NAFTNet (North American Fetal Therapy Network) FETO (Fetoscopic Endoluminal Tracheal Occlusion) Consortium registry, collected between November 1, 2008, and December 31, 2020. In addition to reporting procedure-related surgical outcomes of fetoscopic endoluminal tracheal occlusion, we performed a comparative analysis of fetoscopic endoluminal tracheal occlusion compared with contemporaneous expectantly managed patients.

RESULTS:
Fetoscopic endoluminal tracheal occlusion was successfully performed in 87 of 89 patients (97.8%). Six-month survival in patients with severe left-sided congenital diaphragmatic hernia did not differ significantly between patients who underwent fetoscopic endoluminal tracheal occlusion and those managed expectantly (69.8% vs 58.1%, P=.30). Patients who underwent fetoscopic endoluminal tracheal occlusion had higher rates of preterm prelabor rupture of membranes (54.0% vs 14.3%, P<.001), earlier gestational age at delivery (median 35.0 weeks vs 38.3 weeks, P<.001), and lower birth weights (mean 2,487 g vs 2,857 g, P=.001). On subanalysis, in patients for whom all recorded observed-to-expected lung/head ratio measurements were below 25%, patients with fetoscopic endoluminal tracheal occlusion required fewer days of extracorporeal membrane oxygenation (ECMO) (median 9.0 days vs 17.0 days, P=.014).

CONCLUSION:
In this cohort, fetoscopic endoluminal tracheal occlusion was successfully implemented across several North American fetal therapy centers. Although survival was similar among patients undergoing fetoscopic endoluminal tracheal occlusion and those expectantly managed, fetoscopic endoluminal tracheal occlusion in North American centers may reduce morbidity, as suggested by fewer days of ECMO in those patients with persistently reduced lung volumes (observed-to-expected lung/head ratio below 25%).
Visual Performance and Higher Order Aberrations Obtained With Omafilcon A Dual-Focus and Single-Vision Contact Lens Designs
Authors: Valencia-Nieto Laura , Novo-Diez Andrea , Mangas-Alonso María , Rojas-López Alba , López-de la Rosa Alberto , López-Miguel Alberto 
Published: December 2023

Objective:
The purpose of this study was to assess the visual performance and monochromatic higher-order aberrations (HOAs) obtained while wearing a MiSight dual-focus (DF) contact lenses (CL) in comparison with a single-vision contact lens (SVCL).

Methods:
A randomized, double-masked, cross-over study was performed. Participants were fitted with a DFCL and a SVCL composed of the same material (omafilcon A) and parameters. Logarithm of the Minimum Angle of Resolution high-contrast (100%) and low-contrast (10%) visual acuity (VA) and contrast sensitivity (CS) for 3, 6, 12, and 18 cycles per degree were measured. Higher-order aberrations were also evaluated using a Hartmann–Shack aberrometer with the CLs on.

Results:
Twenty-four subjects (21 females and 3 males) with a mean age of 21.9±1.9 years (range: 18–27) were included. Low-contrast VA was significantly lower with the DFCL regarding the SVCL design (0.39±0.23 vs 0.25±0.18, P=0.002). However, there were no differences in high-contrast VA between both CLs (−0.03±0.10 vs −0.09±0.14, P=0.187). Contrast sensitivity was lower with the DFCL under all spatial frequencies (P≤0.048). Second-, third-, fourth-, and fifth-order aberrations were significantly (P<0.001) higher for the DFCL. There were also significant differences between DFCL and SVCL in defocus (0.87±0.28 vs 0.16±0.35, P<0.001), oblique trefoil (−0.16±0.27 vs −0.01±0.08, P=0.005), vertical coma (0.13±0.17 vs 0.00±0.08, P=0.002), and spherical aberration (0.09±0.11 vs −0.02±0.05, P=0.002).

Conclusion:
Visual performance for detecting low-contrast targets is reduced when wearing MiSight DFCL compared with a SVCL with the same material. The main reason might be the induction of second-order and HOAs by the DFCL design.
Effect of Anterior Chamber Air on Central Corneal Thickness in Human Donor Eyes
Authors: Huertas-Bello Marcela , Seery Christopher W. , Sem Karen , Fout Elizabeth , Triglia Concetta , Eghrari Allen O. , Koo Ellen H. 
Published: December 2023

Purpose:
The purpose of this study was to describe the effects of intracameral air on corneal edema.

Methods:
A laboratory investigation was performed on human donor corneas. Baseline pachymetry measurements through anterior segment optical coherence tomography and endothelial cell density were obtained for all corneas. Each pair of corneas was separated and randomly assigned to undergo air injection or Optisol-GS into a BIONIKO artificial anterior chamber for 5 minutes at physiologic intraocular pressure confirmed by digital palpation. Photographs were obtained immediately on connection of the cornea to the artificial anterior chamber and on completion of the 5 minutes of treatment, with anterior chamber air being exchanged for Optisol-GS. Pretreatment and posttreatment photographs were obtained. Immediately after treatment, pachymetry was again obtained on all corneas. Pachymetry data underwent statistical analysis.

Results:
Corneal pachymetry improved from 690.5 ± 126.6 to 576.1 ± 87.2 μm, yielding a 114.4 ± 50.4 μm improvement of pachymetry in the group with air injected into the anterior chamber. This was a significant improvement of pachymetry when compared with the group with Optisol-GS injected into the anterior chamber, which showed an improvement from 662.3 ± 126.5 to 613.5 ± 108.0 μm, yielding an improvement of 48.8 ± 34.3 μm.

Conclusions:
Injection of air into the anterior chamber leads to a significant decrease in corneal pachymetry. We thereby propose that injecting air intracamerally is an effective intraoperative intervention when visualization is negatively affected by corneal edema.