bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the common pauraque (Nyctidromus albicollis) cornea using light and scanning electron microscopy
Authors: Tozetti Rafaela Alves Ribon , de Lima Sousa Araújo Rosélia , Moreira Matheus Vilardo Loes , de Souza Akiyama Larissa Cristina , Corrêa José Raimundo , Moore Bret A. , Galera Paula Diniz 
Published: October 2023

AbstractThe common pauraque Nyctidromus albicollis (Gmelin, 1789) is a widespread avian species; however due to its nocturnal habits and reclusive behaviour, little is known about their vision and ecology. Most avian species are visually dependent with advanced visual systems providing high spatial resolution, on the species needs. Each ocular structure has a specific role in contributing towards high visual function, and the cornea is the first refractive structure in the visual process. However, the common pauraque cornea had not been described until the present data. Therefore, this study aims to describe the morphology and morphometry of the common pauraque cornea by means of light and scanning electron microscopy to evaluate the cross‐sectional anatomy as well as the ultrastructure of the endothelial cells. Histological similarities with the cornea of other birds have been observed, but the thickness of the common pauraque cornea is much smaller than the other described corneas. A better understanding of the common pauraque cornea can help us better explain the physiology of vision and the visual requirements of this species. In turn, this will help us better understand how this species successfully interacts with its environment, and will improve our knowledge on how to interpret pathological changes in their cornea in a clinical setting.
Weaving relationships: Tobacco, women, and peace in Ovejas, Sucre, Colombia1
Authors: Carmona González Diana Esperanza , Vanegas Daniela , Vidal Katherine 
Published: October 2023

AbstractStarting from the little recognition that women have been given in both economic and productive life, as well as in the processes aimed at peacebuilding, this article reflects on the relationship between women, tobacco labor, and peacebuilding, based on work conducted with women in contexts of armed conflict and post‐agreement in the Montes de Maria region of Colombia, specifically with the Cocinando Ideas Collective in the Municipality of Ovejas, Sucre. The research is conducted through social constructionism and participatory action research, based on the following questions: how has tobacco labor impacted the lives of women in the Montes de Maria region? And how can tobacco labor become an element of peaceful mediation for women survivors of armed conflict? Three conclusions are drawn: the first shows some visible aspects and reveals other invisible aspects regarding the role of women in tobacco labor. The second accounts for positive and negative elements in how the tobacco profession is represented by women. Finally, the article explores the meaning tobacco has had in the territory in terms of peacebuilding and its role in the political transition of the region.
The debate continues on the best age to stop breastfeeding
Authors: Corsello Antonio , Agostoni Carlo 
Published: October 2023

AbstractThe ongoing debate on the optimal duration of breastfeeding in high‐income countries is challenging. The decision to continue breastfeeding beyond the introduction of solids according to WHO indications involves multifaceted considerations, such as nutritional needs, psychological factors and cultural influences, given the growing number of immigrants. The impact on maternal health, sleep routines and family dynamics should be carefully weighed too.ConclusionNext studies should investigate associations of different modalities and periods of breastfeeding with physical and neurodevelopmental outcomes, including psychological aspects. A personalised and gradual approach is suggested, guided by informed decisions and a supportive network.
A randomized, multicenter, double‐blinded parallel study to evaluate the safety and performance of zoledronate‐coated versus uncoated dental implants in partially edentulous patients
Authors: Mokhtari Reza A. , Olsson Morgan , Östman Per‐Olov , Dahlin Christer 
Published: October 2023

AbstractObjectiveTo evaluate patient safety, implants survival and implant stability of the bisphosphonate (zoledronate) as a coating on dental implants in patients requiring oral rehabilitation in the posterior maxilla.Materials and MethodsIn this multicenter, double‐blind, randomized controlled study, 62 patients were randomized to receive either zoledronate‐coated or uncoated control implants in the premolar or molar area of the maxilla, using a one stage‐protocol. Due to dropouts and exclusion 49 patients completed the study. The implants were examined by resonance frequency analysis (RFA) using an implant stability quotient (ISQ) scale at the time of insertion, and at 8 weeks, and after 12 weeks prior to prosthetic restoration. Radiographs were taken prior to surgery, directly after insertion, and during the follow‐up at 12 weeks, 6 months, and 1 year to analyze changes in marginal bone levels (MBL). Finally, all complications and adverse effects (AE) were observed and recorded.ResultsOut of 62 included patients, 49 patients completed the study. No AE were reported by patients receiving zoledronate‐coated implants. There was no statistically significant difference between the zoledronate‐coated or uncoated implant groups when comparing ISQ levels at insertion and after 12 weeks of healing, the mean of the ISQ values demonstrated a change of 4.64 (95% confidence interval: 15.46; 5.79, p = 0.43) between the two groups. At 8‐ and 12‐weeks, ISQ values remained stable (range 62–70). Radiographic analysis showed no statistically significant difference in MBL between the two implant groups after 1 year of loading neither at the mesial side (p = 0.99) or the distal side (p = 0.97). MBL for coated implants were 0.57 mm at the mesial side and 0.46 mm at the distal side. For the uncoated implants, MBL was 0.48 mm at the mesial side and 0.47 mm at the distal side.ConclusionThe zoledronate‐coated dental implants are safe to use in a one‐stage surgery protocol in patients requiring oral rehabilitation in the posterior maxilla, after 1 year of loading. There were no statically significant changes in implant stability and marginal bone levels measured by intraoral radiographs in comparison to uncoated control implants.
Industry and conservation goals are complementary for the most valuable fishery in the United States under climate‐driven life history changes
Authors: Hunt Noah , Pikitch Ellen , Shank Burton , Hodgdon Cameron T. , Chen Yong 
Published: October 2023

AbstractCrustaceans, which are highly susceptible to the effects of climate change, are critical for food security worldwide. Yet, management rarely evaluates the performance of alternative regulatory strategies under climate‐driven life history change. This limits the development of climate‐ready management plans, undermining fisheries sustainability. We compared the performance of alternative minimum legal size (MLS) regulations under shifts in growth and maturity for American lobster in the Gulf of Maine, the most valuable single‐species commercial fishery in the United States. Across the life history change scenarios examined, increasing MLS improved status indicators, while decreasing MLS eroded status indicators for spawning stock biomass, legal abundance, landings, and exploitation rate. Our results demonstrate that protecting the lobster stock by increasing MLS improves fishery output, highlighting that conservation and industry goals can be complementary. This study exemplifies the utility of MLS as a conservation measure for crustacean fisheries under climate change.
CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways
Authors: Xu Hui , Wang Jin , Al‐Nusaif Murad , Ma Huipeng , Le Weidong 
Published: October 2023

AbstractIn non‐small cell lung cancer (NSCLC), metastasis is the most common phenotype, and autophagy plays a vital role in its regulation. However, there are limited data on how autophagy‐related genes and metastasis‐related genes affect NSCLC progression. Our goal was to identify the genes that regulate autophagy and metastasis in NSCLC, and to assess the underlying mechanisms in this current study. RNA sequencing data from public databases were used to screen differentially expressed autophagy‐ and metastasis‐associated genes. Enrichment analyses and immune correlations were conducted to identify hub genes and potential regulating pathways in NSCLC. In this study, we found that CCL2 expression was highly expressed in NSCLC tissues and high CCL2 level was correlated with strong infiltration in lung tissues from NSCLC patients. Overexpression of CCL2 can enhance the metastasis of NSCLC cells in nude mice. Furthermore, CCL2 activated the PI3K/Akt/mTOR signalling pathway axis, promoted epithelial–mesenchymal transition (EMT), and blocked the autophagic flux in NSCLC cells. Therefore, our results indicate that CCL2 promotes metastasis and EMT of NSCLC via PI3K/Akt/mTOR axis and autophagy signalling pathways. We believe that CCL2 could be a probable target for the diagnosis and therapeutics of NSCLC, and this study may expand our understanding of lung cancer.
Rademikibart (CBP‐201), a next‐generation monoclonal antibody targeting human IL‐4Rα: Two phase I randomized trials, in healthy individuals and patients with atopic dermatitis
Authors: Wang Junying , White Jeffery , Sansone Kenneth J. , Spelman Lynda , Sinclair Rodney , Yang Xin , Pan Wubin , Wei Zheng 
Published: October 2023

AbstractIL‐4 and IL‐13 signaling via IL‐4Rα plays key roles in the pathogenesis of atopic dermatitis (AD) and asthma. Rademikibart (formerly CBP‐201), a next‐generation human IgG4 kappa monoclonal antibody, blocks IL‐4Rα‐mediated signal transduction. We performed two phase I, randomized, double‐blind, placebo‐controlled trials. In a single‐ascending dose trial, 40 healthy adults were randomized 3:1 to rademikibart (75–600 mg s.c., 300 mg i.v.) or placebo, with 12 weeks of follow‐up. In the multiple‐ascending dose trial, 31 adults with moderate‐to‐severe AD were randomized 4:1 to once weekly rademikibart (75–300 mg s.c.) or placebo for 4 weeks, plus 7 weeks of follow‐up. Most treatment‐emergent adverse events (TEAEs) were mild; none were serious. Two s.c. injection site reactions and one TEAE of conjunctivitis were reported, all were mild. Rapid and sustained improvements were observed in AD severity and in quality of life (QoL), without plateauing. At week 4, efficacy scores improved by a maximum of −74.4% (Eczema Area and Severity Index), −62.7% (body surface area), −52.8% (Pruritus Numerical Rating Scale [PNRS] severity), −54.4% (PNRS frequency), and − 69.9% (Dermatology Life Quality Index). Thymus activation regulated chemokine inflammatory biomarker concentrations decreased in both trials (−55.4% in the pooled rademikibart arms vs. +18.0% with placebo, at week 5, in patients with AD). Exposure to rademikibart increased in a greater than dose‐proportional manner, suggesting nonlinear clearance. In summary, rademikibart was well‐tolerated and associated with rapid and sustained improvements in eczematous lesions, pruritus, QoL, and inflammatory biomarker concentrations during 4 weeks of treatment. Efficacy responses did not plateau and were generally dose dependent. These promising findings support further development of rademikibart in patients with AD.
Deep learning based identification of aquatic and semi aquatic plants
Authors: Dubey Ashwani Kumar , Thanikkal Jibi G. 
Published: October 2023

AbstractBotanists use morphological features of leaves for aquatic and semi‐aquatic plants identification. In deep learning, the convolution process is efficacious to label images. Existing studies showed that, in deep learning‐based leaf identification, direct image pixel values are used. Leaf images have similar sizes and almost equal pixel values. So, the pixel‐based leaf naming procedure makes uncertainty in the feature results. The direct evaluation of image pixels for leaf image identification is not an effective method, because it is leading to a forgetting problem in continuous learning. Using the pre‐processed databases, researchers are achieving more than 99% accurate results using deep learning. However, the same model fails to reproduce the same result in databases. In this study, morphological features of aquatic and semi‐aquatic plant leaves are converted into digital descriptors to avoid uncertainty in the feature results. In this digital descriptor‐based deep learning method, morphological features of aquatic and semi‐aquatic plant leaves are used. This is equivalent to Botanists' morphological features‐based leaf identification technology. Morphological feature extraction and digital descriptor generation helped this model to achieve 95% accuracy. In this model, leaf morphological features are used for training, so this help to understand the leaf properties of other leaf databases.
Juvenile waiting stage crown‐of‐thorns sea stars are resilient in heatwave conditions that bleach and kill corals
Authors: Byrne Maria , Deaker Dione J. , Gibbs Mitchell , Selvakumaraswamy Paulina , Clements Matthew 
Published: October 2023

AbstractThe juveniles of predatory sea stars can remain in their recruitment–nursery habitat for some time before their ontogenetic shift to the adult habitat and diet. These small juveniles are vulnerable to a range of factors with their sensitivity amplified by climate change‐driven ocean warming. We investigate the thermal tolerance of the waiting stage herbivorous juveniles of the keystone coral predator, the crown‐of‐thorns sea star (COTS, Acanthaster sp.), in context with the degree heating weeks (DHW) model that predicts coral bleaching and mass mortality. In temperature treatments ranging from +1 to 3°C in prolonged heatwave acclimation conditions, the juveniles exhibited ~100% survival in DHW scenarios that trigger coral bleaching (4 DHW), resulting in mass mortality of corals (8 DHW) and extreme conditions well beyond those that kill corals (12 DHW). This indicates that herbivorous juvenile COTS are far more resistant to heatwave conditions than the coral prey of the adults. The juveniles exhibited higher activity (righting) and metabolic rate after weeks in increased temperature. In separate acute temperature experiments, the upper thermal limit of the juveniles was 34–36°C. In a warming world, juvenile COTS residing in their coral rubble nursery habitat will benefit from an increase in the extent of this habitat due to coral mortality. The juveniles have potential for long‐term persistence as herbivores as they wait for live coral to recover before becoming coral predators, thereby serving as a proximate source of COTS outbreaks on reefs already in a tenuous state due to climate change.
Validation of an open source, remote web‐based eye‐tracking method (WebGazer) for research in early childhood
Authors: Steffan Adrian , Zimmer Lucie , Arias‐Trejo Natalia , Bohn Manuel , Dal Ben Rodrigo , Flores‐Coronado Marco A. , Franchin Laura , Garbisch Isa , Grosse Wiesmann Charlotte , Hamlin J. Kiley , Havron Naomi , Hay Jessica F. , Hermansen Tone K. , Jakobsen Krisztina V. , Kalinke Steven , Ko Eon‐Suk , Kulke Louisa , Mayor Julien , Meristo Marek , Moreau David , Mun Seongmin , Prein Julia , Rakoczy Hannes , Rothmaler Katrin , Santos Oliveira Daniela , Simpson Elizabeth A. , Sirois Sylvain , Smith Eleanor S. , Strid Karin , Tebbe Anna‐Lena , Thiele Maleen , Yuen Francis , Schuwerk Tobias 
Published: October 2023

AbstractMeasuring eye movements remotely via the participant's webcam promises to be an attractive methodological addition to in‐person eye‐tracking in the lab. However, there is a lack of systematic research comparing remote web‐based eye‐tracking with in‐lab eye‐tracking in young children. We report a multi‐lab study that compared these two measures in an anticipatory looking task with toddlers using WebGazer.js and jsPsych. Results of our remotely tested sample of 18‐27‐month‐old toddlers (N = 125) revealed that web‐based eye‐tracking successfully captured goal‐based action predictions, although the proportion of the goal‐directed anticipatory looking was lower compared to the in‐lab sample (N = 70). As expected, attrition rate was substantially higher in the web‐based (42%) than the in‐lab sample (10%). Excluding trials based on visual inspection of the match of time‐locked gaze coordinates and the participant's webcam video overlayed on the stimuli was an important preprocessing step to reduce noise in the data. We discuss the use of this remote web‐based method in comparison with other current methodological innovations. Our study demonstrates that remote web‐based eye‐tracking can be a useful tool for testing toddlers, facilitating recruitment of larger and more diverse samples; a caveat to consider is the larger drop‐out rate.
Understanding collaborative and coordinated care in a mental health and well‐being context: Essential elements for effective service integration
Authors: Williams Bronwyn , Charleston Rosemary , Innes Stanley , McIver Shane 
Published: October 2023

AbstractMultiple system reforms in Australia, including the National Disability Insurance Scheme (NDIS), are changing mental health (MH) and disability‐related service provision, whilst policy drivers continue to require service integration. This has necessitated service providers discovering new ways of working collaboratively to achieve an integrated model of care. This qualitative study examined what does and does not work to support collaborative and coordinated care (CCC), as essential components of service integration. The study sample (n = 59) included four cohorts: health and community service leaders (n = 16), staff (n = 23); MH service consumers with complex needs (n = 10), and MH carers (n = 10). Thematic analysis from interviews was applied to data from each cohort to identify overarching themes that described the lived experience of current CCC delivery. COREQ and EQUATOR guidelines were applied to reporting the findings. Themes emphasized CCC is enabled by the development and sustainability of positive working relationships, and depth of knowledge across health and community services. Unnavigable service systems, stigmatization, perceived power differentials, multiple and rapid service reforms and Fee‐For‐Service (FFS) models provide significant barriers to CCC. Recommendations include the need for accessible service navigation, consumer‐friendly service environments, a stable workforce, standardization of knowledge across sectors, outcome measures and funding attached to CCC as part of a raft of potential changes.
COVID‐19 and the impact on Alzheimer's disease pathology
Authors: Furman Susana , Green Kim , Lane Thomas E. 
Published: October 2023

AbstractCoronavirus disease 2019 (COVID‐19) has rapidly escalated into a global pandemic that primarily affects older and immunocompromised individuals due to underlying clinical conditions and suppressed immune responses. Furthermore, COVID‐19 patients exhibit a spectrum of neurological symptoms, indicating that COVID‐19 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID‐19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID‐19 and AD share pathological features and risk factors. This leads us to question whether COVID‐19 is a risk factor for AD and how these two conditions might influence each other. Considering the extensive reach of the COVID‐19 pandemic and the devastating impact of the ongoing AD pandemic, their combined effects could have significant public health consequences worldwide.image
Retrospective comparative study of robot‐assisted surgery, laparoscopic surgery, and laparotomy for endometrial cancer in patients with a low risk of recurrence
Authors: Hayashi Shigehiro , Yamanaka Zenta , Kojima Junya , Ono Masataka , Sasaki Toru , Yamamoto Akiko , Ono Masanori , Futagami Masayuki , Nishi Hirotaka 
Published: October 2023

AbstractAimMinimally invasive surgeries for endometrial cancer are increasing worldwide. In Japan, some articles have examined surgical outcomes, but only a few have addressed oncological outcomes. This study aims to compare robot surgery, laparoscopic surgery, and laparotomy in terms of surgical and oncological outcomes within a low‐risk group for endometrial cancer recurrence.MethodsThis study included patients with endometrial cancer deemed to be at low risk of recurrence and who underwent surgery between January 2011 and December 2020. We studied 99 patients who underwent robot surgery, 85 patients who underwent laparotomy, and 77 patients who underwent laparoscopic surgery. Surgical and oncological outcomes were compared retrospectively for these groups of patients.ResultsThe median follow‐up period was 47, 61, and 60 months in the laparotomy, laparoscopy, and robotic groups, respectively. The three groups had similar perioperative and pathological data. No significant differences in overall survival and disease‐free survival were observed among the groups. Univariate and multivariate analyses conducted on the overall study population for disease‐free survival and overall survival showed that the surgical approach did not have any influence. Minimally invasive surgery groups had longer operating times compared to the laparotomy group, but they had significantly less blood loss. The number of resected pelvic lymph nodes was similar, and the complication rate was not significant.ConclusionsRobot‐assisted surgery and laparoscopic surgery were found to be less invasive and showed similar oncologic outcomes compared to laparotomy surgery for endometrial cancer in patients with a low risk of recurrence.
Depicting Bourdieu's Concepts as a Set of Stackable and Transparent Lenses
Authors: Lewer Kelly 
Published: October 2023

AbstractPierre Bourdieu's concepts of capital, field and habitus were originally used to understand inequalities in education in the 1970's. Today they are readily applied in other disciplines and contexts. This paper firstly explores the author's understanding of the concepts of capital, field and habitus as a depiction as a set of lenses, and suggests the application of this framework to further understand the experiences and trajectories of pre‐registration nursing students to contribute to improvements in policy and service provision.