bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptual constancy for an odour is acquired through changes in primary sensory neurons
Authors: Conway Mark , Oncul Merve , Allen Kate , Johnston Jamie 
Published: November 2023

SummaryThe ability to consistently recognise an object despite sensory input that varies with environmental conditions and/or distance from the object is termed perceptual constancy. This is not an innate ability, rather it develops early in life and is likely dependent upon experience (1,2). The neural mechanisms underpinning the development of perceptual constancy are poorly understood. We have taken advantage of the olfactory system of mice and show that when mice are naïve to an odour a perceptual shift occurs with increasing concentration. The perceptual shift coincides with a rapid reduction in activity of a single olfactory receptor channel that is most sensitive to the odour. This drop in activity is not a property of circuit interactions within the olfactory bulb, rather it is due to a sensitivity miss-match of olfactory receptor neurons within the nose. We show that after forming an association of this odour with food, the sensitivity of the receptor channel is matched to the odour object, preventing transmission failure and promoting perceptual stability. These data show that plasticity of the primary sensory organ enables learning of perceptual constancy.
Programming Probiotics: Diet-responsive gene expression and colonization control in engineeredS. boulardii
Authors: Durmusoglu Deniz , Haller Daniel J. , Al’Abri Ibrahim S. , Day Katie , Sands Carmen , Clark Andrew , San-Miguel Adriana , Vazquez-Uribe Ruben , Sommer Morten O. A. , Crook Nathan C. 
Published: November 2023

AbstractSaccharomyces boulardii(Sb) is an emerging probiotic chassis for delivering biomolecules to the mammalian gut, offering unique advantages as the only eukaryotic probiotic. However, precise control over gene expression and gut residence time inSbhave remained challenging. To address this, we developed five ligand-responsive gene expression systems and repaired galactose metabolism inSb, enabling inducible gene expression in this strain. Engineering these systems allowed us to construct AND logic gates, control the surface display of proteins, and turn on protein production in the mouse gut in response to a dietary sugar. Additionally, repairing galactose metabolism expandedSb’s habitat within the intestines and resulted in galactose-responsive control over gut residence time. This work opens new avenues for precise dosing of therapeutics bySbvia control over itsin vivogene expression levels and localization within the gastrointestinal tract.
Combining evolution and protein language models for an interpretable cancer driver mutation prediction with D2Deep
Authors: Tzavella Konstantina , Diaz Adrian , Olsen Catharina , Vranken Wim 
Published: November 2023

AbstractThe mutations driving cancer are being increasingly exposed through tumor-specific genomic data. However, differentiating between cancer-causing driver mutations and random passenger mutations remains challenging. State-of-the-art homology-based predictors contain built-in biases and are often ill-suited to the intricacies of cancer biology. Protein Language Models have successfully addressed various biological problems but have not yet been tested on the challenging task of cancer driver mutation prediction at large scale. Additionally, they often fail to offer result interpretation, hindering their effective use in clinical settings. The AI-based D2Deep method we introduce here addresses these challenges by combining two powerful elements: i) a non-specialized protein language model that captures the makeup of all protein sequences and ii) protein-specific evolutionary information that encompasses functional requirements for a particular protein. D2Deep relies exclusively on sequence information, outperforms state-of-the-art predictors and captures intricate epistatic changes throughout the protein caused by mutations. These epistatic changes correlate with known mutations in the clinical setting and can be used for the interpretation of results. The model is trained on a balanced, somatic training set and so effectively mitigates biases related to hotspot mutations compared to state-of-the-art techniques. The versatility of D2Deep is illustrated by its performance on non-cancer mutation prediction, where most variants still lack known consequences. D2Deep predictions and confidence scores are available viahttps://tumorscope.be/d2deepto help with clinical interpretation and mutation prioritization.
Remedial education program for Syrian refugees: ensuring their learning during a protracted crisis
Authors: Komatsu Taro , Ghalawinji-Yamamoto Kaoru , Iwama Yukari , Hattori Sayo 
Published: November 2023

PurposeThe purpose of this paper is to explore how vulnerable refugee children's education can be supported in the first asylum country during a long-term, complex crisis. More specifically, the authors examine the impact of a remedial education (RE) program on academically challenged Syrian refugees' sustained learning and well-being in Jordan during a protracted emergency.Design/methodology/approachUsing the 2012 United Nations human security framework, the authors analyze the quantitative results of program evaluation, supplemented by qualitative surveys and stakeholder interviews that asked about the aspirations of refugee children and their guardians, their school experience and the refugee–host community relationship.FindingsThe authors' data suggest that the program enhanced targeted Syrians' protection and empowerment. Their increased sense of safety and improved academic performance and learning motivation were likely owing to child-friendly classroom management and pedagogies that facilitated interactive and differentiated learning. Their human security was further strengthened when they learned with Jordanian children who experienced similar academic challenges and with teachers sympathetic to their plight. Meanwhile, a human security framework calls for humanitarian agencies' strategic engagement with local partners to ensure refugees' learning continuity.Originality/valueRefugee education studies in first asylum countries are rare. Even rarer are studies focusing on academically low-achieving refugees with full consideration of the protracted and complex nature of a crisis. This study suggests effective measures to increase their human security while calling for humanitarian aid organizations to use long-term thinking.
Blended learning classroom model: a new extended teaching approach for new normal
Authors: Inprasitha Maitree 
Published: November 2023

Purpose The purpose of this research is to explore how and to what extent the Blended Learning Classroom (BLC) model enhances students’ learning experience. The creation of the BLC model was to provide different learning approaches to overcome the challenges in the new normal regarding how we could manage the Thailand Lesson Study Incorporated Open Approach (TLSOA) model to maximize students’ independent learning.Design/methodology/approach The researcher employed a participatory observation research design for 178 participants consisting of directors and teachers from 62 schools using a purposive sampling technique. Data were collected using the stimulated recall technique that allowed the participants to reflect and discuss what was happening while they were applying the BLC model.Findings A total of 84.9 percent of participants agreed and strongly agreed with the benefits of implementing the BLC model. The results revealed that Lesson Study (LS) teams created the problem situations substantially by emphasizing across-subject. The qualitative findings revealed that there are three valuable insights in terms of the strengths, challenges and effectiveness of implementing the BLC model.Research limitations/implications These discussions are limited to a study representative of 62 out of 274 project schools.Practical implications The successful implementation of the BLC model requires effective planning, ongoing support for teachers and a suitable infrastructure to ensure access to technology.Originality/value This research adds new insight to the scarce amount of literature on students’ active, interactive and self-regulated learning in a BL environment.
Financial distress prediction in private firms: developing a model for troubled debt restructuring
Authors: Mehmood Asad , De Luca Francesco 
Published: November 2023

Purpose This study aims to develop a model based on the financial variables for better accuracy of financial distress prediction on the sample of private French, Spanish and Italian firms. Thus, firms in financial difficulties could timely request for troubled debt restructuring (TDR) to continue business.Design/methodology/approach This study used a sample of 312 distressed and 312 non-distressed firms. It includes 60 French, 21 Spanish and 231 Italian firms in both distressed and non-distressed groups. The data are extracted from the ORBIS database. First, the authors develop a new model by replacing a ratio in the original Z”-Score model specifically for financial distress prediction and estimate its coefficients based on linear discriminant analysis (LDA). Second, using the modified Z”-Score model, the authors develop a firm TDR probability index for distressed and non-distressed firms based on the logistic regression model.Findings The new model (modified Z”-Score), specifically for financial distress prediction, represents higher prediction accuracy. Moreover, the firm TDR probability index accurately depicts the probabilities trend for both groups of distressed and non-distressed firms.Research limitations/implications The findings of this study are conclusive. However, the sample size is small. Therefore, further studies could extend the application of the prediction model developed in this study to all the EU countries.Practical implications This study has important practical implications. This study responds to the EU directive call by developing the financial distress prediction model to allow debtors to do timely debt restructuring and thus continue their businesses. Therefore, this study could be useful for practitioners and firm stakeholders, such as banks and other creditors, and investors.Originality/value This study significantly contributes to the literature in several ways. First, this study develops a model for predicting financial distress based on the argument that corporate bankruptcy and financial distress are distinct events. However, the original Z”-Score model is intended for failure prediction. Moreover, the recent literature suggests modifying and extending the prediction models. Second, the new model is tested using a sample of firms from three countries that share similarities in their TDR laws.
How electronic word of mouth (eWOM) shapes consumer social media shopping
Authors: Beck Brittany , Moore Koskie Melanie , Locander William 
Published: November 2023

Purpose
This study aims to contribute to the ongoing discussion of how consumers approach shopping directly via social media by explicating decisions related to trust on social media and how various types of electronic word of mouth (eWOM; ratings and reviews, recommendations and referrals and social media communities) contribute to these decisions.

Design/methodology/approach
A total of 198 respondents with experience shopping directly via social media were instructed to select the platform on which they had the most shopping experience (Facebook, Instagram, TikTok, Pinterest, etc.) to answer relevant survey questions. Structural equation modeling (SEM) was used for analyzing the results.

Findings
Findings reveal that eWOM provided by strong ties (recommendations and referrals; social media communities) is superior to weak ties (ratings and reviews). Surprisingly, ratings and reviews do not significantly relate to trust in the retailer, suggesting that this information may be necessary but not sufficient for trusting retailers on social media.

Originality/value
This research distinguishes trust decisions related to shopping on social media and clarifies how each type of eWOM uniquely influences trust in the retailer by using tie strength theory.
Financial innovations in terrorism financing: a case study of Malaysian terror financing
Authors: Zahari Afzal Izzaz , Said Jamaliah , Abdullah Kamarulnizam , Mohd Noor Norazam 
Published: November 2023

Purpose
This paper aims to employ the use of focus groups composed of enforcement officers to explore and identify the financial methods used by terrorism-related organisations in Malaysia.

Design/methodology/approach
The study used an open-ended question and focus group methods to gather information from 20 Malaysian enforcement officers with extensive experience in dealing with terrorism-related activities, as they strive to prevent and counter terrorism incidents. In addition, experienced practitioners and field experts also contributed to the study.

Findings
The study reveals various innovative financial methods used by terrorist-linked organisations to evade detection by local enforcement agencies. These findings are consistent with previous research, which highlights the intelligence of these organisations in avoiding detection by financial regulators.

Research limitations/implications
The findings are based on the perspectives of enforcement officers involved in preventing and countering terrorism activities. Further research could be conducted to gather insights from other government agencies, such as the judiciary or local agencies.

Practical implications
The study offers practical suggestions for organisations and institutions on effectively monitoring and taking appropriate actions in financial activities related to terrorism.

Originality/value
This study provides unique insights into the financial methods of terrorism-related organisations in an emerging country in Southeast Asia. Its findings can be applied throughout the region, given the country’s global connectivity. Furthermore, the study is distinctive in that it provides information from enforcement officers within terrorism-related government organisations, an area where resources are limited. The study also considers the impact of the pandemic on the development of these financial innovations by terrorist organisations.
The role of libraries in academic achievement: case study of Azerbaijan university libraries
Authors: Abdullayeva Narmina 
Published: November 2023

PurposeThe purpose of this study is to examine the importance of libraries in higher education institutes located in Azerbaijan, mainly in the capital city of Baku. Various university libraries have been examined in terms of information services, physical environments and technical equipment support issues.Design/methodology/approachQuestionnaires were completed by students and staff at several universities in Azerbaijan to examine how libraries affect people's academic achievement. The results of this study were comparatively described using multiple tables and graphs.FindingsUniversity library usage is positively associated with academic achievement. Studies have shown that students who use libraries are more likely to succeed academically, as measured by their responses. The role of libraries in academic achievement is not limited to traditional academic tasks such as research and writing.Research limitations/implicationsThe results of this study suggest that there is a positive relationship between library usage and academic achievement in some universities in Azerbaijan, and it is necessary to continue the topic in further studies in a wide range to develop relationships between academic library services and success in higher education, either personal or student.Originality/valueThis study is the first to examine the significance of academic libraries in higher education in Azerbaijan, providing a general overview and analysis of the separate correlations among these variables. Researchers interested in Azerbaijani education and libraries may find this to be practical.
Necessary conjunctions: Hawkspur Camp and the transdisciplinary roots of therapeutic community
Authors: Jones David W. , Fees Craig 
Published: November 2023

Purpose
This paper aims to tell something of the story of the “Hawkspur Experiment” (1936–1941), a therapeutic camp organised early in the modern history of therapeutic community as an intervention into the lives of young men who were viewed to be at risk of delinquency (Wills, 1967). Although it was to have a remarkable influence on group and therapeutic community practice and theory, the authors argue that its influence is not as well-remembered nor incorporated into contemporary therapeutic understanding and discussion as it should be.

Design/methodology/approach
This paper is a historical reflection based on systematic examination of the clinical and administrative records of Hawkspur Camp for men, and supporting documents held in the Planned Environment Therapy Archive. In addition, the authors use published primary and secondary sources.

Findings
Hawkspur Camp was a cross-disciplinary enterprise which brought together psychoanalytic thinking, social work, an interest in groups, political activism, a concern with the dynamics and working of democracy and the application of emergent social science methods. It was overtly an intervention into the criminal justice system but was also an intentional exploration of the therapeutic benefits of community living and of a “pioneering” lifestyle; a rigorous experiment in how psychoanalytic ideas might be used in group residential settings; and a politically grounded exploration of participative democracy as a fundamental therapeutic principle.

Originality/value
To the best of the authors’ knowledge, this paper presents the first findings from a systematic study of the records of Hawkspur Camp.
Support‐Verb Constructions with Objects:Greek‐CopticInterference in the Documentary Papyri?1
Authors: Fendel Victoria Beatrix 
Published: November 2023

AbstractSupport‐verb constructions are combinations of a verb and a noun that fill the predicate slot, for example,to make a suggestioninI made the suggestion yesterday. The article examines direct‐object structures with support‐verb constructions in Greek documentary papyri from fourth‐ to mid‐seventh‐century Egypt. By the fourth century, Greek and Egyptian (at this stage called Coptic) had co‐existed in Egypt for about a millennium and the latter was gaining ground. The article focusses on the support‐verb‐construction families surrounding ἐξουσίανexousian‘power’ and ἐγγύηνegguēn‘surety’ as well as on a selection of structures with ποιέομαιpoieomai‘to do’. The article finds that direct‐object structures in the data sample have differing explanations. Direct‐object patterns are a marginal pattern in classical Greek already, such that some patterns can be explained by inheritance or the extension of a pattern to new contexts. However, some writers either idiolectally or sociolectally applied object patterns more widely based on the Coptic parallel. The syntax of support‐verb constructions in Greek does not run counter to the verbal syntax otherwise, which may aid the fact that they do not introduce systemic changes.
Stressful life events and depressive symptoms during COVID‐19: A gender comparison
Authors: Qian Yue , Fan Wen 
Published: November 2023

AbstractThe COVID‐19 pandemic precipitated a wide range of public health, economic, social, and political shocks, setting in motion life events that reverberated to affect individuals' mental health. Moving beyond a checklist approach, this study drew on individuals' own words to identify both conventional and novel sources of stress during COVID‐19 and examine the role of stressful life events in producing gender disparities in depressive symptoms. Drawing on a 2021 U.S. nationally representative survey, we coded text responses to an open‐ended question on stressful life events and conducted descriptive and regression analyses (n = 1733). The analyses revealed three key findings. First, men were more likely to report having experienced no stressful life events or else mention politics as a source of stress. Women, by comparison, were more likely to report the following as stressful—inability to socialize, paid work, care work, health, or the death of loved ones. Second, for both women and men, respondents reporting no stressful life events had the lowest, and those reporting finances as the most stressful life event had the highest, depressive symptoms. Third, women had higher depressive symptoms than men, and mediation analysis showed that stressful life events explained approximately a third of the gender gap in depressive symptoms. The findings indicate that policies attending to people's financial stress are important for mitigating mental health risks in turbulent times. Interventions that reduce women's exposure to stressful life events are also crucial to bridging gender disparities in mental health.
Environmental sustainability and gynaecological surgery: Which factors influence behaviour? An interview study
Authors: van Nieuwenhuizen Kim E. , Both Ingena G. I. A. , Porte Petra J. , van der Eijk Anne C. , Jansen Frank Willem 
Published: November 2023

AbstractObjectiveTo assess the various factors that influence environmentally sustainable behaviour in gynaecological surgery and examine the differences between gynaecologists and residents.DesignAn interview study.SettingAcademic and non‐academic hospitals in the Netherlands.PopulationGynaecologists (n = 10) and residents (n = 6).MethodsThematic analysis of semi‐structured interviews to determine the various factors that influence environmentally sustainable behaviour in gynaecological surgery and to examine the differences between gynaecologists and residents. By using the Desmond framework and the COM‐B BCW, both organisational and individual factors related to behaviour were considered.Main outcome measuresFactors that influence environmentally sustainable behaviour.ResultsAwareness is increasing but practical knowledge is insufficient. It is crucial to integrate education on the environmental impact of everyday decisions for residents and gynaecologists. Gynaecologists make their own choices but residents’ autonomy is limited. There is the necessity to provide environmentally sustainable surgical equipment without compromising other standards. There is a need for a societal change that encourages safe and open communication about environmental sustainability. To transition to environmentally sustainable practices, leadership, time, collaboration with the industry and supportive regulatory changes are essential.ConclusionThis study lays the groundwork for promoting more environmentally sustainable behaviour in gynaecological surgery. The key recommendations, addressing hospital regulations, leadership, policy revisions, collaboration with the industry, guideline development and education, offer practical steps towards a more sustainable healthcare system. Encouraging environmentally sustainable practices should be embraced to enhance the well‐being of both our planet and our population, driving us closer to a more environmentally sustainable future in healthcare.