bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspektif Pasien Gagal Ginjal Terminal (GGT) yang Menjalani Terapi Hemodialisis Ditinjau dari Konsep Efikasi Diri (Self Efficacy)
Authors: Kurniawan Yayan , Yani Sutri 
Published: November 2023

Angka kejadian GGK secara global meningkat lebih dari 500 juta orang dan penderita harus menjalani hemodialisis sebanyak 1,5 juta orang. Angka kematian yang disebabkan GGK disinyalir masih cukup tinggi. Sebagai upaya untuk mempertahankan kelangsungan hidupnya maka diperlukan terapi pengganti ginjal bagi pasien. Hingga saat ini terapi pengganti ginjal yang efektif dan efisien hanya terapi hemodialysis. Beberapa literature mempublikasikan bahwa pada pasien yang baru pertama menjalani terapi hemodialysis akan mengalami masalah psikososial. Beberapa penelitian telah banyak menyororoti tentang gambaran efikasi diri (self efficacy) pada berbagaai penyakit kronis. Efikasi diri ini sendiri memiliki makna tantang kepercayaan diri pasien dengan kondisinya untuk memutuskan/ melakukan suatu tundakan. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif phenomenology. Semua responden dalam penelitian ini merupakan pasien Gagal Ginjal Terminal (GGT) yang menjalani terapi hemodialysis sebanyak 10 orang. Sampling dilakukan dengan metode Purposive sampling yang mengacu dengan kriteria tertentu. Teknik pengumpulan data dilakukan dengan metode In depth interview terhadap 5 aspek efikasi diri. Analisa data dilakukan dengan metode Colaizzi dengan berdasarkan 4 tahapan analisa data. Hasil penelitian ini didapatkan bahwa persepsi pasien GGT yang menjalani terapi hemodialisa yang ditinjau dari konsep efikasi diri (self efficacy) dikategorikan baik. Kondisi ini difaktori oleh karena lama menjalani terapi lebih dari 1 tahun, sehingga dimungkinkan pasien tersbut sudah beradaptasi dengan keadaan.
Faktor-Faktor Yang Berhubungan Dengan Kejadian HIV/AIDS Di Puskesmas Penurunan Kota Bengkulu Tahun 2022
Authors: Herlinda Femi , Diniarti Fiya , Darmawansyah Darmawansyah 
Published: November 2023

HIV/AIDS di Kota Bengkulu tahun 2020 sebesar 73 kasus, tahun 2021 sebesar 111 kasus. Kasus HIV/AIDS tertinggi tahun 2021 berada di puskesmas Penurunan sebesar 111 kasus. Penelitian ini bertujuan menganalisis Faktor –faktor yang berhubungan dengan Kejadian HIV/AIDS di Wilayah Kerja Puskesmas Penurunan Kota Bengkulu tahun 2022. Penelitian ini menggunakan metode kuantitatif dengan menggunakan rancangan case control study. Jumlah sampel 66 responden yang terdiri dari 33 sampel kasus dan 33 sampel kontrol dengan teknik pengambilan sampel menggunakan teknik total sampling pada sampel kasus dan purposive sampling pada sampel control dengan menggunakan instrumen kuesioner dan pengolahan data menggunakan SPSS 16. Hasil penelitian dari hasil uji statistik Chi-Square (continuity correction) usia yaitu dengan p-value=0,258> a0.05 dan nilai OR didapat sebesar 4,639 (95% CI = 8,987-6,765), jenis kelamin yaitu dengan p-value= 0,010 > a0.05 dan nilai OR didapat sebesar 6,719 (95% CI=8,657-3,765), pengetahuan yaitu dengan p-value= 0,00,012< a0.05 dan nilai OR didapat sebesar 3,517 (95% CI = 0,543-11,765), dan riwayat IMS yaitu dengan p-value= 0,013 > a0.05 dan nilai OR didapat sebesar 2,719 (95% CI = 1,876-13,875), Saran bagi Puskesmas Penurunan Kota Bengkulu Diharapkan puskesmas dapat mengoptimalkan dan meningkatkan pencegahan HIV/AIDS dengan melakukan pelaksanaan program kegiatan, pembinaan, dan konseling dalam upaya meningkatkan pengetahuan pencegahan HIV/AIDS.
A rare case of Ewing's sarcoma in a 4-year-old child treated by tumor endoprosthetics using 3D printing
Authors: Stavrev Vladimir , Stokov Luben , Ganev Petko , Georgiev Georgi 
Published: November 2023

Orthopedic oncology surgery often requires, by its very nature, precise and often extensive resections of bone and soft tissue involved in or near the tumor mass.
One of the most recent and promising innovations is represented by 3D printing technology, whose main advantage in this field of application is patient specificity, which is essential in an operation that requires high precision and maximum respect for the individuality of his bones and soft tissues.
Material and methods: In the present report, we present a 4-year-old boy diagnosed with Ewing's sarcoma involving ¾ of the right tibia. In another medical facility, he was offered amputation. Our team decided to use the "3D printed tumor megaendoprosthesis, double growing, from the Czech company Prospon. For reinsertion of the muscle groups to the endoprosthesis, we used a LARS textile tube that was attached to the femoral and tibial components of the endoprosthesis. A vascular surgeon also participated in the team. The patellar ligament was reinserted to the tibial component, and myoplasty was additionally performed with the medial head of the m. gastrocnemius. Intraoperatively, we lengthened the lower limb by 1.5 cm to delay the upcoming staged lengthening.
Results: The postoperative period was uneventful, with sutures removed on the 12th postoperative day. For 3 weeks, a tutor orthosis was placed. Active physiotherapy was started after removal of the orthosis 21 days after surgery.
Conclusion: Our goal is to perform a total revision at the end of skeletal growth if possible and replace the current implant with a non-growing tumor megaendoprosthesis in the absence of near or distant metastases and long-term patient survival.
Future expectations are that non-invasive lengthening mechanisms or a biological approach will be able to meet the special needs of this population.
A Study on Evaluating the Impact of Social Media's Fake News on The Attitudes and Beliefs of a Society
Authors: Khurram Sultan Langraw  , Adil Zaman  
Published: November 2023

The widespread availability of misleading information in this age of instantaneous information dissemination through social media platforms has prompted significant worry about its possible impact on people's worldviews. The major purpose of this research is to assess the influence of false news on social media on people's opinions and worldviews. Using a combination of quantitative surveys and qualitative content analysis, this research examines the frequency with which people are exposed to fake news. And moreover, it investigates the cognitive processes underlying the approval or rejection of such news, as well as its subsequent impact on individuals' attitudes and beliefs. The findings demonstrate a multifaceted correlation between misinformation exposure and changes in attitudes and beliefs. Regular exposure to misinformation is statistically associated with a decline in trust in conventional media outlets, according to the findings of a quantitative study. Individuals and society are affected by the implications of these findings, which have far-reaching effects. The decline in trust in conventional media underscores the critical need for media literacy education, which equips individuals with the ability to evaluate the veracity of information critically. In addition, the research highlights the importance of users in appropriately sharing content and the value of social media platforms in limiting the spread of disinformation. The results add to our growing knowledge of the complex link between fake news and public opinion. This provides policymakers, journalists, and educators with useful knowledge for navigating the current media environment. By illuminating the interplay between information intake, belief formation, and the rise of digital communication, this study betters our capacity to comprehend the multifaceted effects of fake news on social media. This research has important implications for the design of effective measures to reduce the societal harm caused by deception.
Keyword: Social Media's, Fake News, Attitudes,
Effects of high molecular weight n-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride on the barrier integrity of Caco-2 monolayer
Authors:   , Wongwanakul Ratjika 
Published: November 2023

Development of poorly soluble and unstable peptide drugs using drug delivery system has been introduced to improve drug bioavailability via oral administration. Among the oral drug carriers interested in synthetic polymers, 600-HPTChC is the modified chitosan with quaternization process to improve solubility without any effect on the mucoadhesive property of core chitosan. However, the biocompatibility of 600-HPTChC on human intestine and its mechanism on paracellular and transcellular transport remained to be unknown. The purposes of this study were therefore to determine the effects of 600-HPTChC on intestinal cells in aspects of cell proliferation and cell differentiation and to examine the potential effects of 600-HPTChC on improvement of drug bioavailability through paracellular and transcellular pathway using Caco-2 cells as an in vitro intestinal model.

The results demonstrated that lower degree of substitution of 600-HPTChC caused lower cytotoxic and anti-proliferative effect on Caco-2 cells comparing to the higher degree of substitution. In addition, anti-proliferative effect of 600-HPTChC might be involved by cell cycle disturbance further causing differentiation delay of the Caco-2 cells after the continuous exposure for 9 days. However, 4 h/day exposure over 9 days, more realistically mimics the daily intestinal exposure, could attenuate the effect of 600-HPTChC on intestinal differentiation. In paracellular pathway, 600-HPTChC was much more efficient than chitosan in both aspects of opening rate and time recovery of tight junction protein. The results also suggested that the mechanism behind the tight junction opening might result from the direct interaction between 600-HPTChC and tight junction protein rather than via intracellular signaling investigated. In transcellular pathway, 600-HPTChC was able to increase the drug absorption by P-gp inhibition without any change in the expression level. Immunofluorescent images indicated that 600-HPTChC could directly bind to P-gp on plasma membrane. Furthermore, the results of P-gp ATPase assay demonstrated that 600-HPTChC acts as the stimulator of P-gp ATPase that might relate to conformation change of P-gp epitope. Overall data support the usefulness of 600-HPTChC as a drug carrier in development of the oral drug delivery system.
Simulation of complex triaxial tests with HySand, a new multisurface constitutive model in the hyperplastic framework
Authors: Simonin Luc , Houlsby Guy , Byrne Byron 
Published: November 2023

Offshore wind has a key role to play in the energy transition. The majority of offshore wind turbines (OWTs) are bottom-founded with monopiles [1]. Monopiles account for up to 35% of the installation cost of the OWT [2, 3]. Optimising the design of monopiles can thus lead to significant savings and increased competitiveness of OWTs in the energy market.
The PISA project [4] has led to the optimisation of the design under monotonic lateral loading of monopiles founded in sands, clays, and layered profiles [5 ,6, 7]. Because of this optimisation, along with the increasing size of OWTs, and the deeper waters where they are installed, design under cyclic loading is becoming crucial. There are, however, significant shortcomings in current design methods to predict the effects of cyclic loading on a monopile: accumulated rotation, changes in stiffness, energy dissipation and strength.
The PICASO project, a joint research project between the University of Oxford and Ørsted, seeks to develop a new design method for monopiles under cyclic loading in sands and clays. Similarly to PISA [8,9], this design method will use the finite element method to simulate the behaviour of monopiles. For PICASO, such simulation requires constitutive models able to capture the behaviour of soil under cyclic loading. However, available advanced constitutive models for sand face severe limitations [10, 11] and are not satisfactory for the simulation of cyclic loading.
HySand [12, 13], a family of models developed in the hyperplastic framework, fills this gap. HySand_base is a 14 parameter multisurface plasticity model with non-linear elasticity, shear plasticity and hardening, and two plastic volumetric mechanisms resulting in non-associative plasticity: one dilation mechanism which value depends on the evolving density and anisotropy of the sample, and one density dependent consolidation mechanism.
This document presents comparisons between the database on Karlsruhe fine sand by Wichtmann [14] and results of simulations with HySand_base. The focus will be on complex tests that other models fail to simulate adequately, such as undrained strain-controlled cyclic tests. Data and simulation with HySand_base of such test on medium dense sand are presented in Figure 1.
HySand_base performs well across densities and types of triaxial tests. This gives confidence in its existing three-dimensional implementation in finite element codes, and demonstrates its value to future design processes.
A sequentially coupled chemical-mechanical damage constitutive model for carbonate rocks
Authors: Li Hao , Pel Leo , Smeulders David , Zhong Ruizhi , You Zhenjiang 
Published: November 2023

Modelling the constitutive relations of chemically corroded carbonate rocks is important for the design and stability evaluation of engineering constructions in karst areas (e.g., mines, tunnels and dams, etc.) [1-4]. This paper presents a sequentially coupled chemical-mechanical (C-M) damage constitutive model for engineering rocks in karst areas. First, the chemical damage caused by carbonate dissolution and the mechanical damage caused by external loads are investigated based on experimental results. After that, the chemical damage is expressed by the degradation ratio of Young's modulus under the effect of the chemically induced secondary pores compaction. The chemically induced secondary pore is quantified by reactive transport behavior considering the geochemical procedure of free-face dissolution and precipitation under different H+ concentrations, temperature and corrosion periods [5]. The mechanical damage is formulated based on a statistical theory [6,7], which underlines the strength of the mesoscopic element and considers the damage initiation threshold. To capture the nonlinear strength responses of the mesoscopic element at various chemical damage and confining pressures, a modified Mohr-Coulomb (M-C) criterion is introduced, in which the instantaneous friction angle and cohesion are expressed as functions of the confining pressure and chemical damage. The proposed model is validated and shows good agreement with experimental data.
Result of this research shows that: (1) the porosity increases with increasing corrosion period and the increase rate (i.e., the slope of the porosity curve) is steep initially and then decreases gradually (see Fig. 1 (a)). (2) As shown in Fig. 1 (b), Young's modulus decrease with porosity growth. (3) The C-M coupled damage evolution curve is S-shaped and consists of four stages (see Fig. 1(c)), i.e., a linear elastic stage, a stable damage stage, a damage acceleration stage and a post-peak stage. In damage stage 1, stress is lower than the mechanical damage initiation threshold and the stress-strain curve is in a linear elastic state. At this stage, mechanical damage doesn’t initiate (i.e., ). Therefore, the total damage (Dcm) evolution curve is horizontal and only contains chemical damage (Dc=0.165) caused by carbonate dissolution. Once the axial strain exceeds the mechanical damage initiation threshold, the damage enters stage 2. In this stage, total damage (Dcm) begins to slightly rise and steadily increases with the increasing load. In damage stage 3, the damage-strain curve rises concave upward. After the peak strength point, damage development comes to stage 4, i.e., the post-peak stage.
The Impact of the Characteristics of the Learning Organization on the Effectiveness of Crisis Management Stages: A Field Study in the Social Security Corporation in the Southern Region of Jordan
Authors: Al –Abadleh Abdalrahman 
Published: November 2023

The study aimed to analyze the impact of learning organization characteristics in the effectiveness of crisis management stages in the social security corporation, Southern region of Jordan. The study population consisted of all employees in the mentioned branches that consisted of (150) participants. The study used the analytical descriptive method. Statistical methods were used based on (SPSS- Version-20) to answer the questions and testing hypotheses. The study concluded that the level of availability the characteristics of learning organization in the social Security Corporation in the southern region of Jordan, and that the level of effectiveness of crisis management stages level have a high degree. The study showed that there is a statistically significant effect for the characteristics of learning organization and all its dimensions on the effectiveness of crisis management stages. The study recommended forming permanent emergency teams to deal with crises, and delegating authorities to the branches to provide an element of speed in detecting crises and treating damages.
The Impact of Systematic Risk on Stock Return of Jordanian Commercial Banks Listed on the Amman Stock Exchange during the Period (2000-2020)
Authors: Abu Obaid Alaa , Al-Ruqaybat Ghazi 
Published: November 2023

This study aimed to measure the impact of systemic risks (beta coefficient and inflation) on the stock returns of Jordanian commercial banks during the period (2000-2020). The study sample consisted of all Jordanian commercial banks listed on the Amman Stock Exchange. The study used several statistical methods to reveal the association of the independent variables with the dependent variable, where the descriptive analytical approach was adopted to analyze the data in addition to the multiple regression analysis. The results of the study showed that regarding the systemic risks, there is a negative impact of the beta coefficient on stock returns, while it was found that there is a positive effect of inflation on the stock returns of Jordanian commercial banks. The study recommended the development of better policies to face risks, which in turn reduces the profits of commercial banks.
Ensayo clínico sobre la eficacia de la educación sanitaria previa a entrar en quirófano
Authors: Morales Hernández Rosario , De Sousa Pereira Pimental Correia Ana Margarita , García Sánchez Francisco Javier , Mudarra García Natalia 
Published: November 2023

La ansiedad es una emoción con la que los pacientes deben lidiar al enfrentarse a una intervención quirúrgica. Esto se debe al miedo que generan la circunstancias que rodean la intervención. La enfermera tiene como función fundamental el proporcionar la información adecuada para satisfacer y contrarrestar las inquietudes del paciente.
Los objetivos principales fueron, determinar los niveles de ansiedad previo a la cirugía y analizar la satisfacción de los pacientes.
Este estudio se trata de un ensayo clínico aleatorizado, no cegado, prospectivo y controlado. Se analizaron variables como ¿Cree que se debería dar esta educación sanitaria a todos los pacientes antes de la cirugía?, ¿Cree que hubiera estado menos nervioso si hubiera recibido educación sanitaria?, ¿Después de la operación, sabe a dónde le van a llevar? y escala de ansiedad (APAIS).
Un total de 36 pacientes fueron incluidos en el estudio. A 18 de ellos se les dio educación sanitaria antes de la intervención y a otros 18 no.
Se encontraron resultados estadísticamente significativos en cuanto a conocimientos del paciente sobre donde le van a llevar tras la intervención (0,002), sobre si piensa continuamente en la anestesia (<0,001), sobre si le gustaría recibir información lo más completa posible sobre la anestesia (0,038), sobre si está inquieto respecto a la intervención (<0,001), sobre si piensa continuamente en la intervención (<0,001)
Concluimos que una educación sanitaria previa a la intervención quirúrgica reduce los niveles de ansiedad en relación a la cirugía.
Humanización de cuidadores principales y profesionales en adultos mayores
Authors: Rodríguez Ayllón Karina , Salazar Altamirano Yudy Orfilia 
Published: November 2023

Antecedentes. Se ha evidenciado según la OMS la existencia de maltrato a adultos mayores, convirtiéndose en un problema importante de salud pública. En un estudio de revisión bibliográfica realizada en 28 países identificaron que 1 de que cada 6 personas sufrieron algún tipo de maltrato como: abuso psicológico, físicos, económico, desatención y abusos sexuales en entornos comunitarios, hospitales y residencias de ancianos u otros centros de atención especializada.
Objetivo. Analizar evidencia científica sobre el cuidado humanizado a la persona de la tercera edad por el cuidador principal y el profesional.
Material y método. El diseño es de revisión bibliográfica, se ha seguido las directrices según PRISMA a través de la búsqueda de artículos basados en la variable “humanización del cuidado de cuidadores profesionales y principales”.
Conclusiones. Tanto los cuidadores profesionales como los cuidadores principales están incorporando el cuidado humanizado en el cuidado a la persona de la tercera edad, los profesionales con algunas herramientas más que contribuyen en su desenvolvimiento profesional y los cuidadores principales con mayores carencias y con riesgos de padecer problemas emocionales como estrés o angustia, Se hace necesario que para ambos grupos se establezcan programas de capacitación específicas sobre las necesidades y fortalezas de la persona de la tercera edad para garantizar un mejor cuidado y por ende una mejor calidad de vida.
Sobrecarga del cuidador principal del paciente trasplantado de pulmón en un hospital terciario
Authors: Sánchez De la Ventana María de los Ángeles 
Published: November 2023

Introducción. El trasplante de pulmón es la única opción terapéutica de pacientes con enfermedad pulmonar terminal.Es considerado un paciente crónico complejo y tener una red de apoyo familiar es requisito para llevar a cabo el trasplante.
Objetivo. Analizar la posible sobrecarga del cuidador principal informal del paciente trasplantado de pulmón y factores asociados.
Metodología. Estudio observacional, descriptivo, transversal, mediante muestreo no probabilístico por conveniencia en un hospital terciario. Entregamos una encuesta a los cuidadores, con variables sociodemográficas, escala de Zarit reducida y espacio para comentarios. Fue voluntaria, autoadministrable y anónima. Se ha utilizado la prueba de Chicuadrado para la comparación de variables.
Resultados. Según la escala un 37% de los cuidadores presenta sobrecarga. No se halló relación estadísticamente significativaentre el nivel de sobrecarga y las variables sociodemográficas recogidas.
Conclusiones. Mujer, entre 51-60 años, sin estudios o que trabaja fuera de casa más de 8 horas diarias representa el perfil con mayor sobrecarga, así como durante la primera y última etapa tras el trasplante y la falta de formación en cuidados propios del trasplante. Debemos diseñar herramientas específicas para analizar el rol del cuidador de estos pacientes y así como grupos de apoyo interdisciplinar para responder sus necesidades.