bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on earthquake and tsunami hazard: evaluating probabilistic seismic hazard function (PSHF) and potential tsunami height simulation in the coastal cities of Sumatra Island
Authors: Triyoso Wahyu , Kongko Widjo , Prasetya Gegar S. , Suwondo Aris 
Published: January 2024

This study uses integrated geological, geodesy, and seismology data to assess the potential tsunami and Probabilistic Seismic Hazard Function (PSHF) near Sumatra’s coastal cities. It focuses on estimating the possible level of ground shaking due to the seismic activity within the Sumatran Fault Zone (SFZ) and subduction zone. It uses the Peak Ground Acceleration (PGA) as a measure. An amplification factor that is based on the previous study is used. It is calculated through the Horizontal-Vertical Spectral Ratio (HVSR), which measures possible surface ground shaking. The Seismic Hazard Function (SHF) is calculated considering magnitudes 6.5 to 9.0 for subduction sources and 6.5 to 7.8 for SFZ sources. Also, the PGA based on the Maximum Possible Earthquake (MPE) magnitude is estimated, and tsunami heights are simulated to assess the possible hazard risk. The tsunami source model in this study is characterized by considering the possibility of the long-term perspectives on giant earthquakes and tsunamis that might occur in subduction zones around the off-coast of southern Sumatra Island. The potentiality source zone is characterized based on the utilization of the cross-correlation of correlation dimension (DC) based on the shallow earthquake catalog of 2010 to 2022 and the SHmax-rate of surface strain rate. Based on the MPE, the relatively high estimated PGA at the base rock was found around Mentawai and Pagai Utara islands at about 0.224 g and 0.328 g, with the largest estimated PGA based on the MPE at the surface with values of about 0.5 g and 0.6 g. The possible maximum tsunami height (Hmax) estimated based on source scenarios position around the west coast of Sumatera Island, such as for Kota Padang and Kota Bungus, reaches up to 12.0 m and 22.0 m, respectively. The findings provide valuable insight into seismic and tsunami hazards, benefiting future mitigation strategies.
Lived experience, power that a degree cannot give you: a phenomenological study of one Hispanic woman leader in academia
Authors: Perez Mayra , Kelley Allyson , Ceballos Venice , Milligan Kelley , Cabrera Alejandra 
Published: January 2024

IntroductionStructural racism, bias, and discrimination within institutions of higher education prevent Hispanic women from becoming university leaders and professors, especially when they do not have a formal degree. Hispanic leaders in higher education often have lived experiences based on their cultural values, family connections, and time working in community settings. However, lived experience is not always viewed as an equal qualification to college degrees when it comes to teaching, leading, or managing programs and departments.MethodsThe purpose of this study is to present a case study of one program operations director (leader) working at a University who does not have a terminal or advanced degree but holds the lived and professional experiences of working in community health worker programs with minority and underserved populations. This study examined her experience as a Hispanic female leading in higher education. We used qualitative phenomenological methods grounded in a descriptive case study design to inform our work.ResultsThe themes from the analysis process represent how LE influences the participant’s work as a leader in academia and give insight into how she navigates academia without a college degree.DiscussionHigher education must meet the needs of Hispanic students and leaders. By elevating Hispanic women in leadership positions, even without degrees, institutions of higher education are demonstrating a commitment to Hispanic student support, development, diversity, and culture.
The first compound heterozygous mutations in SLC12A3 and PDX1 genes: a unique presentation of Gitelman syndrome with distinct insulin resistance and familial diabetes insights
Authors: Yin Yaqi , Li Liqin , Yu Songyan , Xin Yu , Zhu Lili , Hu Xiao , Chen Kang , Gu Weijun , Mu Yiming , Zang Li , Lyu Zhaohui 
Published: January 2024

BackgroundGitelman Syndrome (GS) patients frequently exhibit disrupted glucose metabolism, attributed to hypokalemia, hypomagnesemia and heightened aldosterone. This study delved into the genetic underpinnings linked to insulin resistance and diabetes in a GS patient, contextualized within his family history.MethodsThe hydrochlorothiazide and furosemide loading test were performed to ascertain the presence of GS. Oral glucose tolerance test (OGTT) evaluated glucose metabolism and insulin sensitivity. Whole-exome sequencing, validated by Sanger sequencing, was employed to confirm gene mutations, which were then tracked among the patient’s relatives.ResultsSymptoms and laboratory examination confirmed the clinical diagnosis of GS. Comprehensive whole-exome sequencing, augmented by Sanger sequencing validation, revealed a compound heterozygous mutation within the SLC12A3 gene (c.1108G&gt;C in exon 9, c.676G&gt;A in exon 5 and c.2398G&gt;A in exon 20) in the patient. The OGTT affirmed diabetes and heightened insulin resistance, distinct from previous patients with GS we evaluated. Further genetic analysis identified a missense heterozygous mutation (c.97C&gt;G in exon 1) within the PDX1 gene, inherited from the patient’s diabetic mother without GS. Furthermore, the patient’s brother, with impaired glucose tolerance but regular potassium levels, also bore this mutation, hinting at additional impacts of the PDX1 gene mutation on glucose metabolism regulation beyond the known impacts of GS.ConclusionThis study unveils unprecedented compound heterozygous mutations in the SLC12A3 and PDX1 genes in a GS patient. These findings illuminate the potential complex genetic factors influencing glucose metabolism disruptions in GS.Take-home messageThis research uncovers a novel combination of SLC12A3 and PDX1 gene mutations in a Gitelman Syndrome patient, revealing intricate genetic factors that potentially disrupt glucose metabolism and shedding light on familial diabetes links.
Case report: Target and immunotherapy of a lung adenocarcinoma with enteric differentiation, EGFR mutation, and high microsatellite instability
Authors: Yang Meiling , Yu Pengli , He Zhiyi , Deng Jingmin 
Published: January 2024

BackgroundPulmonary enteric adenocarcinoma (PEAC) is a rare histological subtype of non-small-cell lung cancer (NSCLC) with a predominant (&gt;50%) enteric differentiation component. The frequency of high microsatellite instability (MSI-H) is very low in lung cancer. EGFR tyrosine kinase inhibitors and immunotherapy are standard treatment for NSCLC patients, but their effectiveness in lung adenocarcinoma with pulmonary enteric differentiation is unknown.Case presentationThis report describes a 66-year-old man who was initially diagnosed with metastatic lung adenocarcinoma with EGFR mutation based on pleural fluid. A lung biopsy was obtained after 17 months of first-line icotinib treatment. Histological analysis of biopsy samples and endoscopic examination resulted in a diagnosis of adenocarcinoma with enteric differentiation. Next-generation sequencing of 1,021 genes showed EGFR E19del, T790M, and MSI-H, while immunohistochemical assay showed proficient expression of mismatch repair (MMR) proteins. Consequently, the patient was treated with osimertinib and had a progression-free survival (PFS) of 3 months. His treatment was changed to chemotherapy with/without bevacizumab for 6.5 months. Then, the patient was treated with one cycle of camrelizumab monotherapy and camrelizumab plus chemotherapy, respectively. The tumor continued to grow, and the patient suffered pneumonia, pulmonary fungal infections, and increased hemoptysis. He received gefitinib and everolimus and died 2 months later and had an overall survival of 30 months.ConclusionIn summary, our case describes a rare pulmonary enteric adenocarcinoma with an EGFR-activating mutation and MSI-H, responding to an EGFR tyrosine kinase inhibitor and poorly benefiting from an immune checkpoint inhibitor.
Identification of RNA silencing suppressor encoded by citrus chlorotic dwarf-associated virus
Authors: Ye Xiao , Ding Dongdong , Chen Yuan , Liu Chuang , Li Zhongan , Lou Binghai , Zhou Yan 
Published: January 2024

IntroductionCitrus chlorotic dwarf-associated virus (CCDaV) is an economically important citrus virus associated with leaf curling, deformation, and chlorosis found in China. Plants have evolved RNA silencing to defend against viral infections; however, the mechanism by which CCDaV suppresses RNA silencing in citrus remains unknown.MethodsSix proteins encoded by CCDaV were ectopically expressed in Nicotiana benthamiana 16c using the pCHF3 vector to identify RNA-silencing suppression activities.ResultsV2 protein encoded by CCDaV suppressed local RNA silencing and systemic RNA silencing triggered by GFP RNA, but did not impede short-distance movement of the RNA silencing signal in N. benthamiana 16c. GFP fluorescence observations showed that the ability of V2 protein to suppress RNA silencing was weaker than tomato bushy stunt virus P19. Deletion analysis showed that the putative nuclear localization signal (NLS, 25–54 aa) was involved in the RNA silencing suppression activity of V2 protein. Furthermore, V2 protein cannot block dsRNA-triggered RNA silencing. The subcellular localization assay suggested that V2 protein was localized to nucleus of N. benthamiana.ConclusionOverall, the results of this study demonstrate that CCDaV-V2 acts as an activity of silencing suppression. This is the first reported RNA-silencing suppressor encoded by Citlodavirus and will be valuable in revealing the molecular mechanism of CCDaV infection.
Core microbiota for nutrient digestion remained and ammonia utilization increased after continuous batch culture of rumen microbiota in vitro
Authors: Liu Mengyu , Wang Tong , Wang Lu , Xiao Hanjie , Li Jinhui , Duan Chunhui , Gao Lijie , Liu Yueqin , Yan Hui , Zhang Yingjie , Ji Shoukun 
Published: January 2024

IntroductionThis study aimed to investigate the digestive function, urea utilization ability, and bacterial composition changes in rumen microbiota under high urea (5% urea in diet) over 23 days of continuous batch culture in vitro.MethodsThe gas production, dry matter digestibility, and bacterial counts were determined for the continuously batch-cultured rumen fluid (CRF). The changes in fermentation parameters, NH3-N utilization efficiency, and microbial taxa were analyzed in CRF and were compared with that of fresh rumen fluid (RF), frozen rumen fluid (FRF, frozen rumen fluid at −80°C for 1 month), and the mixed rumen fluid (MRF, 3/4 RF mixed with 1/4 CRF) with in vitro rumen fermentation.ResultsThe results showed that the dry matter digestibility remained stable while both the microbial counts and diversity significantly decreased over the 23 days of continuous batch culture. However, the NH3-N utilization efficiency of the CRF group was significantly higher than that of RF, FRF, and MRF groups (p &lt; 0.05), while five core genera including Succinivibrio, Prevotella, Streptococcus, F082, and Megasphaera were retained after 23 days of continuous batch culture. The NH3-N utilization efficiency was effectively improved after continuous batch culture in vitro, and Streptococcus, Succinivibrio, Clostridium_sensu_stricto_1, p.251.o5, Oxalobacter, Bacteroidales_UCG.001, and p.1088.a5_gut_group were identified to explain 75.72% of the variation in NH3-N utilization efficiency with the RandomForest model.ConclusionThus, core bacterial composition and function retained under high urea (5% urea in diet) over 23 days of continuous batch culture in vitro, and bacterial biomarkers for ammonia utilization were illustrated in this study. These findings might provide potential applications in improving the efficiency and safety of non-protein nitrogen utilization in ruminants.
Clinical significance of type IV vascularization of laryngeal lesions according to the Ni classification
Authors: Staníková Lucia , Kántor Peter , Fedorová Katarína , Zeleník Karol , Komínek Pavel 
Published: January 2024

BackgroundScattered, small, dot-like intraepithelial papillary capillary loops (IPCLs) represent type IV epithelial vascularization according to “Ni classification” and are considered to be nonmalignant. According to the European Laryngological Society classification, these loops are malignant vascular changes. This contradiction has high clinical importance; therefore, clarification of the clinical significance of type IV vascularization according to the Ni classification is needed.MethodsThe study was performed between June 2015 and December 2022. All recruited patients (n = 434) were symptomatic, with macroscopic laryngeal lesions (n = 674). Patients were investigated using the enhanced endoscopic methods of narrow band imaging (NBI) and the Storz Professional Image Enhancement System (IMAGE1 S). The microvascular patterns in the lesions were categorized according to Ni classification from 2011 and all lesions were examined histologically.ResultsA total of 674 lesions (434 patients) were investigated using flexible NBI endoscopy and IMAGE1 S endoscopy. Type IV vascularization was recognized in 293/674 (43.5%) lesions. Among these 293 lesions, 178 (60.7%) were benign (chronic laryngitis, hyperplasia, hyperkeratosis, polyps, cysts, granulomas, Reinkeho oedema and recurrent respiratory papillomatosis); 9 (3.1%) were squamous cell carcinoma; 61 (20.8%) were mildly dysplastic, 29 (9.9%) were moderately dysplastic, 14 (4.8%) were severe dysplastic and 2 (0.7%) were carcinoma in situ. The ability to recognize histologically benign lesions in group of nonmalignant vascular pattern according to Ni (vascularization type I-IV) and distinguish them from precancers and malignancies was with accuracy 75.5%, sensitivity 54.4%, specificity 94.4%, positive predictive value 89.6% and negative predictive value 69.9%.ConclusionLaryngeal lesions with type IV vascularization as defined by Ni present various histological findings, including precancerous and malignant lesions. Patients with type IV vascularization must be followed carefully and, in case of progression mucosal lesion microlaryngoscopy and excision are indicated.
Effectiveness and safety of self-pulling and latter transection reconstruction in totally laparoscopic right hemicolectomy
Authors: Yang Fuyu , He Fan , Tang Chenglin , Chen Defei , Xiong Junjie , Zou Yu , Woraikat Saed , Qian Kun , Li Hui 
Published: January 2024

BackgroundLaparoscopic right hemicolectomy is a standard treatment modality for right colon cancer. However, performing intracorporeal anastomosis (IA) for totally laparoscopic right hemicolectomy (TLRH) remains a challenge for some surgeons. To simplify IA in TLRH we used self-pulling and latter transection (SPLT) reconstruction in TLRH, and compared this procedure with overlap IA and laparoscopy-assisted right hemicolectomy (LARH) in order to evaluate its safety and effectiveness.MethodsPatients with right colon cancer who underwent SPLT-TLRH, TLRH with overlap IA or LARH between July 2019 and June 2023 were evaluated retrospectively. Basic information, oncological features, perioperative outcomes, and postoperative complications were compared between groups.ResultsIn total, 188 patients with right colon cancer that underwent SPLT-TLRH (n = 60), TLRH(n=21) or LARH (n = 107) were included in the study. No patient required conversion to open surgery. The operation time in SPLT-TLRH group was significantly shorter than that in TLRH group (P&lt;0.05). Compared with LARH group, SPLT-TLRH group had significantly longer distal margins, shorter skin incisions (P &lt; 0.001), time to first flatus, time to first defecation, and postoperative hospital stays (P&lt;0.05).ConclusionWe introduced SPLT to TLRH. The SPLT-TLRH group demonstrated better short-term outcomes. Therefore, we believe that SPLT reconstruction is effective and safe in TLRH for right colon cancer, and can simplify reconstruction.
Enhancing preoperative diagnosis of microvascular invasion in hepatocellular carcinoma: domain-adaptation fusion of multi-phase CT images
Authors: Yu Zhaole , Liu Yu , Dai Xisheng , Cui Enming , Cui Jin , Ma Changyi 
Published: January 2024

ObjectivesIn patients with hepatocellular carcinoma (HCC), accurately predicting the preoperative microvascular invasion (MVI) status is crucial for improving survival rates. This study proposes a multi-modal domain-adaptive fusion model based on deep learning methods to predict the preoperative MVI status in HCC.Materials and methodsFrom January 2008 to May 2022, we collected 163 cases of HCC from our institution and 42 cases from another medical facility, with each case including Computed Tomography (CT) images from the pre-contrast phase (PCP), arterial phase (AP), and portal venous phase (PVP). We divided our institution’s dataset (n=163) into training (n=119) and test sets (n=44) in an approximate 7:3 ratio. Additionally, we included cases from another institution (n=42) as an external validation set (test1 set). We constructed three single-modality models, a simple concatenated multi-modal model, two current state-of-the-art image fusion model and a multi-modal domain-adaptive fusion model (M-DAFM) based on deep learning methods. We evaluated and analyzed the performance of these constructed models in predicting preoperative MVI using the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), and net reclassification improvement (NRI) methods.ResultsIn comparison with all models, M-DAFM achieved the highest AUC values across the three datasets (0.8013 for the training set, 0.7839 for the test set, and 0.7454 for the test1 set). Notably, in the test set, M-DAFM’s Decision Curve Analysis (DCA) curves consistently demonstrated favorable or optimal net benefits within the 0-0.65 threshold probability range. Additionally, the Net Reclassification Improvement (NRI) values between M-DAFM and the three single-modal models, as well as the simple concatenation model, were all greater than 0 (all p &lt; 0.05). Similarly, the NRI values between M-DAFM and the two current state-of-the-art image fusion models were also greater than 0. These findings collectively indicate that M-DAFM effectively integrates valuable information from multi-phase CT images, thereby enhancing the model’s preoperative predictive performance for MVI.ConclusionThe M-DAFM proposed in this study presents an innovative approach to improve the preoperative predictive performance of MVI.
Risk factors for urinary tract infection in infants with unexplained hyperbilirubinemia: a single center case-control study
Authors: Chen Ing , Hsu Li-Sang , Yao Cai-Sin , Chang Jenn-Tzong , Wang Hsiao-Ping , Fang Nai-Wen 
Published: January 2024

BackgroundUrinary tract infection (UTI) is a potential cause of neonatal jaundice. Nevertheless, there remains a lack of consensus regarding appropriate screening practices for UTI in infants with hyperbilirubinemia. This study aimed to analyze a group of jaundiced infants to assess the prevalence of UTI, explore potential risk factors, and examine the impact of UTI on the course and severity of neonatal jaundice.MethodsThis retrospective case-control study was conducted on 150 jaundiced infants (aged &lt; 8 weeks) without a known etiology in the hyperbilirubinemia work-up. All subjects underwent phototherapy treatment and UTI screening by catheterization. They were then classified into UTI and non-UTI groups based on urine culture results, with a positive urine culture indicating the growth of ≥10,000 colony-forming units. The clinical characteristics and jaundice-related parameters of both groups were analyzed.ResultsAmong the 150 jaundiced patients, the prevalence of UTI was 29%. There was a significantly higher male predominance in the UTI group, and patients with UTI also had a significantly longer duration of hospitalization compared to those without UTI. Significant risk factors associated with UTI in jaundiced infants included male gender and a peak total bilirubin level higher than 18 mg/dl during hospitalization. The most common pathogens identified in urine culture were Escherichia coli (41.9%) and Enterococcus faecalis (30.2%).ConclusionIn cases of neonatal jaundice where the underlying cause is not evident, screening for UTI should be performed, particularly when associated risk factors or inadequate response to phototherapy is present.
Disproportional signal of pericarditis with biological diseasemodifying antirheumatic drugs (bDMARDs) in patients with ankylosing spondylitis: a disproportionality analysis in the FAERS database
Authors: Xia Shuang , Li Yun-Fei , Raschi Emanuel , Zhang Bi-Kui , Noguchi Yoshihiro , Sarangdhar Mayur , Yan Miao , Ma Jin-An 
Published: January 2024

Objective: This study aimed to investigate the potential association between biological disease-modifying antirheumatic drugs (bDMARDs) and pericarditis and uncover relevant clinical characteristics in ankylosing spondylitis (AS).Methods: Reports of pericarditis recorded in the FDA Adverse Event Reporting System (FAERS) (January 2004–December 2022) were identified through the preferred term “pericarditis.” Demographic and clinical characteristics were described, and disproportionality signals were assessed through the reporting odds ratio (ROR) and information component (IC). A significant signal was detected if the lower bound of IC (IC025) was more than zero.Results: We found 1,874 reports of pericarditis with bDMARDs (11.3% of cases with fatal outcomes). Adalimumab (IC025 3.24), infliximab (IC025 4.90), golimumab (IC025 5.40), certolizumab (IC025 5.43), etanercept (IC025 3.24), secukinumab (IC025 3.97), and ustekinumab (IC025 7.61) exhibit significant disproportionality signals compared to other medications in the FAERS database. After excluding pre-existing diseases and co-treated drugs that may increase the susceptibility of pericarditis, the disproportionality signal associated with infliximab, certolizumab, etanercept, secukinumab, and ustekinumab remained strong. Pericarditis cases associated with all bDMARDs were predominantly recorded in women aged 25–65 years.Conclusion: More reports of pericarditis were detected with AS patients on bDMARDs than with other drugs in the overall database. Further studies are warranted to investigate the underlying mechanisms and identify patient-related susceptibility factors, thus supporting timely diagnosis and safe(r) prescribing of bDMARDs.