bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring experiential learning within interprofessional practice education initiatives for pre-licensure healthcare students: a scoping review
Authors: Nagel Daniel A. , Penner Jamie L. , Halas Gayle , Philip Mark T. , Cooke Carol A. 
Published: February 2024

AbstractBackgroundInterprofessional collaborative team-based approaches to care in health service delivery has been identified as important to health care reform around the world. Many academic institutions have integrated interprofessional education (IPE) into curricula for pre-licensure students in healthcare disciplines, but few provide formal initiatives for interprofessional practice (IPP). It is recognized that experiential learning (EL) can play a significant role supporting IPP education initiatives; however, little is known of how EL is used within education for IPP in healthcare settings.MethodsWe conducted a scoping review to map peer-reviewed literature describing IPP education initiatives involving EL for pre-licensure students in healthcare disciplines. A literature search was executed in MEDLINE, CINAHL, EMBASE, ERIC, PsycINFO, Scopus, and Social Services Abstracts. After deduplication, two independent reviewers screened titles and abstracts of 5664 records and then 252 full-text articles that yielded 100 articles for data extraction. Data was extracted using an Excel template, and results synthesized for presentation in narrative and tabular formats.ResultsThe 100 included articles represented 12 countries and IPP education initiatives were described in three main typologies of literature – primary research, program descriptions, and program evaluations. Forty-three articles used a theory, framework, or model for design of their initiatives with only eight specific to EL. A variety of teaching and learning strategies were employed, such as small interprofessional groups of students, team huddles, direct provision of care, and reflective activities, but few initiatives utilized a full EL cycle. A range of perspectives and outcomes were evaluated such as student learning outcomes, including competencies associated with IPP, impacts and perceptions of the IPP initiatives, and others such as client satisfaction.ConclusionFew educational frameworks specific to EL have been used to inform EL teaching and learning strategies to consolidate IPE learning and prepare students for IPP in healthcare settings. Further development and evaluation of existing EL frameworks and models would be beneficial in supporting robust IPP educational initiatives for students in healthcare disciplines. Intentional, thoughtful, and comprehensive use of EL informed by theory can contribute important advances in IPP educational approaches and the preparation of a future health care workforce.
Anastrozole for the prevention of breast cancer in high-risk postmenopausal women: cost-effectiveness analysis in the UK and the USA
Authors: Wei XiaoXia , Cai Jiaqin , Lin Huiting , Wu Wenhua , Zhuang Jie , Sun Hong 
Published: February 2024

Abstract
Purpose
The effectiveness of anastrozole for breast cancer prevention has been demonstrated. The objective of this study was to evaluate the cost-effectiveness of anastrozole for the prevention of breast cancer in women with a high risk of breast cancer and to determine whether anastrozole for the primary prevention of breast cancer can improve the quality of life of women and save health-care resources.

Methods
A decision-analytic model was used to assess the costs and effects of anastrozole prevention versus no prevention among women with a high risk of breast cancer. The key parameters of probability were derived from the IBIS-II trial, and the cost and health outcome data were derived from published literature. Costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) were calculated for the two strategies,One-way and probabilistic sensitivity analyses were performed.

Results
In the base case, the incremental cost per QALY of anastrozole prevention was £125,705.38/QALY in the first 5 years compared with no prevention in the UK, above the threshold of WTP (£3,000/QALY),and in the 12-year period, the ICER was £8,313.45/QALY, less than WTP. For the US third-party payer, ICER was $134,232.13/QALY in the first 5 years and $8,843.30/QALY in the 12 years, both less than the WTP threshold ($150,000/QALY).

Conclusion
In the UK and US, anastrozole may be a cost-effective strategy for the prevention of breast cancer in high-risk postmenopausal women. Moreover, the longer the cycle of the model, the higher the acceptability. The results of this study may provide a scientific reference for decision-making for clinicians, patients, and national medical and health care government departments.
Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells
Authors: Malara Natalia , Coluccio Maria Laura , Grillo Fabiana , Ferrazzo Teresa , Garo Nastassia C. , Donato Giuseppe , Lavecchia Annamaria , Fulciniti Franco , Sapino Anna , Cascardi Eliano , Pellegrini Antonella , Foxi Prassede , Furlanello Cesare , Negri Giovanni , Fadda Guido , Capitanio Arrigo , Pullano Salvatore , Garo Virginia M. , Ferrazzo Francesca , Lowe Alarice , Torsello Angela , Candeloro Patrizio , Gentile Francesco 
Published: February 2024

Abstract
Background
the problem in early diagnosis of sporadic cancer is understanding the individual’s risk to develop disease. In response to this need, global scientific research is focusing on developing predictive models based on non-invasive screening tests. A tentative solution to the problem may be a cancer screening blood-based test able to discover those cell requirements triggering subclinical and clinical onset latency, at the stage when the cell disorder, i.e. atypical epithelial hyperplasia, is still in a subclinical stage of proliferative dysregulation.

Methods
a well-established procedure to identify proliferating circulating tumor cells was deployed to measure the cell proliferation of circulating non-haematological cells which may suggest tumor pathology. Moreover, the data collected were processed by a supervised machine learning model to make the prediction.

Results
the developed test combining circulating non-haematological cell proliferation data and artificial intelligence shows 98.8% of accuracy, 100% sensitivity, and 95% specificity.

Conclusion
this proof of concept study demonstrates that integration of innovative non invasive methods and predictive-models can be decisive in assessing the health status of an individual, and achieve cutting-edge results in cancer prevention and management.
Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection
Authors: Miao Patrick , Terris-Prestholt Fern , Fairley Christopher K. , Tucker Joseph D. , Wiseman Virginia , Mayaud Philippe , Zhang Ying , Rowley Jane , Gottlieb Sami , Korenromp Eline L. , Watts Caroline G. , Ong Jason J. 
Published: February 2024

Abstract
Background
Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated with syphilis.

Methods
We conducted a systematic review, searching six databases for economic evaluations and primary valuation studies related to syphilis from January 2000 to February 2022. We extracted health state utility values or disability weights, including identification of how these were derived. The study was registered in the international prospective register of systematic reviews (PROSPERO, CRD42021230035).

Findings
Of 3401 studies screened, 22 economic evaluations, two primary studies providing condition-specific measures, and 13 burden of disease studies were included. Fifteen economic evaluations reported outcomes as disability-adjusted life years (DALYs) and seven reported quality-adjusted life years (QALYs). Fourteen of 15 economic evaluations that used DALYS based their values on the original Global Burden of Disease (GBD) study from 1990 (published in 1996). For the seven QALY-related economic evaluations, the methodology varied between studies, with some studies using assumptions and others creating utility weights or converting them from disability weights.

Interpretation
We found a limited evidence base for the valuation of health states for syphilis, a lack of transparency for the development of existing health state utility values, and inconsistencies in the application of these values to estimate DALYs and QALYs. Further research is required to expand the evidence base so that policymakers can access accurate and well-informed economic evaluations to allocate resources to address syphilis and implement syphilis programs that are cost-effective.
Sagittal imbalance syndrome, a new concept, helps determining a long fusion for patients with degenerative lumbar spinal stenosis and severe global sagittal imbalance
Authors: Lu Shibao , Zhu Weiguo , Wang Yu , Kong Chao , Wang Wei , Chen Xiaolong , Li Xiangyu 
Published: February 2024

Abstract
Objective
To retrospectively investigate the postoperative clinical and radiographic outcomes in elderly patients with degenerative lumbar spinal stenosis (DLSS) and severe global sagittal imbalance who underwent different fusion levels.

Methods
A total of 214 patients with DLSS and severe global sagittal imbalance were included. Sagittal imbalance syndrome was defined as the severe decompensated radiographic global sagittal imbalance accompanied with the following symptoms: severe back pain in naturel posture that disappears or significantly relieves in support position, living disability with ODI score > 40% and dynamic sagittal imbalance. Thereinto, 54 patients were found with sagittal imbalance syndrome and were performed the lumbar decompression with a long thoracolumbar fusion (Group A) or a short lumbar fusion (Group B). Thirty patients without sagittal imbalance syndrome who underwent short lumbar decompression and fusion were selected as the control (Group C).

Results
Patients with sagittal imbalance syndrome were detected to have more paraspinal muscle degeneration and less compensatory potentials for sagittal imbalance (smaller thoracic kyphosis and larger pelvic tilt) than those without this diagnosis. Postoperative comparisons revealed significant restoration of global sagittal alignment and balance and improvement of living quality in Groups A and C at the final follow-up. Six patients in Group B and one in Group A were found to have proximal junctional complication during follow-up.

Conclusion
Our results indicated that DLSS patients with sagittal imbalance syndrome had inferior surgical outcomes in terms of living quality and proximal junctional complication after lumbar decompression with a short fusion.
Transforming research to improve therapies for trauma in the twenty-first century
Authors: Juffermans Nicole P. , Gözden Tarik , Brohi Karim , Davenport Ross , Acker Jason P. , Reade Michael C. , Maegele Marc , Neal Matthew D. , Spinella Philip C. 
Published: February 2024

AbstractImprovements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, many patients continue to die from hemorrhage. Also, major knowledge gaps remain on the impact of tissue injury on the host immune and coagulation response, which hampers the development of interventions to treat or prevent organ failure, thrombosis, infections or other complications of trauma. Thereby, trauma remains a challenge for intensivists. This review describes the most pressing research questions in trauma, as well as new approaches to trauma research, with the aim to bring improved therapies to the bedside within the twenty-first century.
Prenatal diagnosis of non-typical Chiari malformation type I associated with de novo Nuclear Factor I A gene mutation: a case report
Authors: Tomai Xuan-Hong , Nguyen Huu-Trung , Nguyen Thi Thanh-Truc , Nguyen Tuan-Anh , Nguyen Thuy-Vy 
Published: February 2024

Abstract
Background
Chiari malformation is one of the most common Central nervous system (CNS) abnormalities that can be detected in routine fetal scanning. Chiari malformation type I (CMI) is a congenital defect characterized by a displacement of the cerebellar tonsils through the foramen magnum. The etiology of CMI has not been well established and suggested having multifactorial contributions, especially genetic deletion. Clinical characteristics of this anomaly may express in different symptoms from neurological dysfunction and/or skeletal abnormalities in the later age, but it is rarely reported in pregnancy.

Case presentation
We present a case in which the Chiari malformation type I was diagnosed with comorbidities of facial anomalies (flatting forehead and micrognathia) and muscular-skeletal dysmorphologies (clenched hands and clubfeet) at the 24+6 weeks of gestation in a 29-year-old Vietnamese pregnant woman. The couple refused an amniocentesis, and the pregnancy was followed up every 4 weeks until a spontaneous delivery occurred at 38 weeks. The newborn had a severe asphyxia and seizures at birth required to have an emergency resuscitation at delivery. He is currently being treated in the intensive neonatal care unit. He carries the novel heterozygous NFIA gene mutation confirmed after birth. No further postnatal malformation detected.

Conclusion
CMI may only represent with facial abnormalities and muscle-skeletal malformations at the early stage of pregnancy, which may also alert an adverse outcome. A novel heterozygous NFIA gene mutation identified after birth helps to confirm prenatal diagnosis of CMI and to provide an appropriate consultation.
Redevelopment of mental health first aid guidelines for substance use problems: a Delphi study
Authors: Wright Judith , Chalmers Kathryn J. , Rossetto Alyssia , Reavley Nicola J. , Kelly Claire M. , Jorm Anthony F. 
Published: February 2024

Abstract
Background
Substance use problems have a major impact on the physical and mental health of individuals, families and communities. Early intervention may have a positive effect on recovery and treatment outcomes for those with substance use problems, reducing related risk and harm. Separate mental health first aid guidelines on how a member of the public could assist someone experiencing or developing alcohol use and drug use problems in high income Western countries were developed using Delphi expert consensus in 2009 and 2011, respectively. This study aimed to synthesise and update these two original guidelines to reflect current evidence and best practice.

Methods
The Delphi expert consensus method was used to determine the inclusion of statements in the redeveloped guidelines. A questionnaire was developed using previously endorsed helping statements from the original guidelines on alcohol and drug use problems, as well as relevant content identified in systematic searches of academic and grey literature. Three panels of experts (people with lived experience, support people and professionals) rated statements over three consecutive online survey rounds to determine the importance of their inclusion in the guidelines. Statements endorsed by at least 80% of each panel were included.

Results
103 panellists completed all three survey rounds. They rated 469 statements and endorsed 300 of these for inclusion in the redeveloped guidelines.

Conclusions
This study has developed a broader and more comprehensive set of guidelines for how to support a person experiencing or developing a substance use problem. The redeveloped guidelines provide more detail on knowledge about and recognition of substance use problems, approaching and assisting people who want to change or are not ready to change, harm reduction, community-based supports and professional help, but have less on physical first aid actions. Mental Health First Aid International will use these guidelines in future updates of their training courses.
Examining successful and unsuccessful time management through process data: two novel indicators of test-taking behaviors
Authors: Papanastasiou Elena C. , Michaelides Michalis P. 
Published: February 2024

AbstractTest-taking behavior is a potential source of construct irrelevant variance for test scores in international large-scale assessments where test-taking effort, motivation, and behaviors in general tend to be confounded with test scores. In an attempt to disentangle this relationship and gain further insight into examinees’ test-taking processes, researchers can now utilize process and timing data to obtain a more comprehensive view of test-taking behaviors, such as test-taking effort. The purpose of this study is to propose and evaluate two novel response-based, standardized indicators of test-taking behaviors that utilize a combination of examinee response and process (timing) data to better understand and describe test-taking effort in ILSAs. These indices were empirically estimated with USA data from two booklets from e-TIMSS 2019 in mathematics for grade 4. In addition, their predictive validity was examined with respect to achievement estimates. Their network of associations with other relevant variables such as motivation, interest in the subject, as well as across subjects were also examined to test their intra-individual stability in e-TIMSS.
Methadone Maintenance Therapy (MMT) and Alternatives in Opioid Use Disorder: Reviewing the latest advancements, outcomes, and challenges in substitutional therapy for opioid addiction - literature review
Authors: Koszyczarek Karolina , Kotowska Maja , Zamirska Wiktoria , Ziemiański Albin , Zięba Katarzyna , Zygmunt Anna , Smuszkiewicz-Różański Paweł , Różańska-Smuszkiewicz Gabriela 
Published: February 2024

Introduction and Purpose: Opioid addiction is a serious challenge for public health worldwide, and methadone maintenance therapy (MMT) is a key therapeutic approach. This review intends to provide an up-to-date summary of the pathophysiology, clinical manifestation, diagnostic techniques, and treatment options for Opioid Use Disorder.

Materials and methods: The literature available in PubMed, Scopus, and Google Scholar databases was reviewed using the following keywords: "MMT," "methadone maintenance therapy", “maintenance therapy”, "opioid use disorder", "opioid addiction," "methadone”, ”naloxone” “naltrexone”, and “buprenorphine”.

State of Knowledge: This review examines current approaches in maintenance therapy for Opioid Use Disorder (OUD). In the study, we focus on treatments using methadone, buprenorphine, naloxone, and naltrexone. It focuses on recent advancements, comparing the effectiveness, safety, and patient outcomes of these therapies. Key challenges in treatment accessibility and implementation are also discussed, providing an updated overview of the field and identifying areas for future research in opioid addiction therapy.
Conclusion: There is a series of studies researching the psychological and behavioral problems associated with opioid addiction. This research has given medical practitioners valuable guidance on effective management techniques. According to the authors, compared to other alternative treatment methods, methadone maintenance therapy (MMT) is still considered the most effective pharmacotherapeutic method in the treatment of opioid addiction. Nevertheless, ongoing research is essential to improve diagnostic processes, develop innovative therapies, and enhance the overall quality of care for those affected by these challenges.
Condyloma acuminata - the review of the treatment methods
Authors: Słowik Magdalena , Gierlach Katarzyna , Nowak Karolina , Nowak Karolina , Drygała Zuzanna , Zielińska Zuzanna , Wyrwał Julia , Olejarz Zuzanna , Krasuska Martyna , Nieć Maria 
Published: February 2024

Introduction and purpose:
Condyloma acuminata, a benign manifestation of HPV infection, is a common sexually transmitted disease. Condyloma acuminata most commonly affects the anogenital area, but can also occur in the oral cavity. Macroscopically the lesions present as raised, fleshy papules, sometimes flat and broad, pedicled or cauliflower-like. Generally, the lesions are multiple, and as they grow, tend to coalesce into larger ones. Due to the lack of symptoms, condyloma acuminata are often found incidentally during routine medical appointments, e.g. in gynecologist’s offices. Additional symptoms and signs are pain, minor bleeding and pruritus. Patients suffering from condyloma acuminata are often in psychological and psychosexual distress.
This work aims to provide a summary of the currently available treatment options based on scientific reports to date.
A brief description of the state of knowledge:
Among the factors that increase the risk of the HPV infection are age, lifestyle, promiscuity, smoking, HIV infection, a history of chlamydia or gonorrhea infections. To date, no treatment algorithm has been developed for condyloma acuminata. Two vaccines are on offer as primary prevention, Gardasil and Cervarix. The available treatment options are divided into two main groups: patient-administered and physician administered. Surgical methods have the highest therapeutic efficacy. Condyloma acuminata has a high recurrence rate. Usually, a multi-session combination treatment is needed to reach total remission.
Summary (conclusions):
The treatment of condyloma acuminata includes personalized targets due to their diverse clinical picture and the limitations of certain patient groups. The available treatment options do not exhaust the needs of patients suffering from condyloma acuminata. Further research into the effectiveness of specific treatments is advisable.
Atopic dermatitis - itchy problem of children and adults
Authors: Lasota Nina , Demidowicz Gabriela , Trąbka Natalia , Lasek Patryk , Smerdzyński Maciej , Łach Katarzyna , Ściurka Kinga , Kowalczyk Klaudia , Panuciak Kinga , Kozicka Karolina 
Published: February 2024

Atopic dermatitis is a chronic inflammatory disease with recurrent exacerbations, persistent itching, erythema, dry skin due to damage to the epidermal barrier, and staphylococcal infections. The causative factors are mutations in the gene encoding filaggrin, dysregulation of the immune system, changes in the skin microbiome and lipids in the stratum corneum and deficiency of antimicrobial peptides AMPs. The disease mainly affects children, causing a significant deterioration in the quality of life, and its first symptoms occur in approximately 90% before the age of 5. Lesions most often appear on the bends of elbows and knees, on the face and neck, but may also affect the skin of the entire body (erythroderma). The location of the eruptions depends on age. Atopic dermatitis is the result of complex genetic, epigenetic, environmental and immunological interactions with a coexisting epidermal barrier defect. The disease is diagnosed based on the Hanifin and Rajka criteria. Treatment of atopic dermatitis is symptomatic and selected individually. They include the elimination of provoking factors, care of the epidermal barrier, and anti-inflammatory and anti-pruritic therapy.