bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced value-added bioproducts from microalgae
Authors: Saxena Pallavi , Majhi Pritikrishna , Pithania Ruchi , Tarigholizadeh Sarieh , Harish  , Minkina Tatiana 
Published: December 2023

Abstract
Currently, the world is facing major issues of degradation of land by natural as well as anthropogenic activities such as desertification, salinization, industrialization, pollution and population growth. The limited resources and the expanding global population require alternative resources to meet the demands in the future. Microalgae are contemplated as a favorable resource for high-value products, including carotenoids, phycobilin, astaxanthin, docosahexaenoic acid, eicosahexaenoic acid and omega-3/6 polyunsaturated fatty acids. Although the use of algae is not new, the idea of developing high value-added products concerning sustainability, economic viability, nutrition enrichment and environmental friendliness is attracting researchers to explore more about the potential of microalgal flora. Microalgae not only thrive under extremophilic conditions but also do not compete with plants for land resources. Having a short generation period, diverse biochemical composition, low-cost nutritional needs and fixation of CO2 are also significant reasons to promote their products. Also, the biorefinery concept and sustainable cultivation possibilities can substantially add to enabling sustainable production of high-value biomolecules, while proposing opportunities for increasing sustainable food and fuel supplies. However, a few challenges like inadequate domestic demand, constant maintenance of ideal conditions for cultivation and food regulations still need to be overcome.
Hand hygiene practices among primary and secondary school students in sub-Saharan Africa: a systematic review
Authors: Bishoge Obadia Kyetuza , Omary Mwanaidi , Liheluka Edwin , Mshana Jonathan Mcharo , Nguyamu Maryyusta , Mbatia Yolanda Joseph , Njee Robert Mussa , Kafuye Mwanaidi 
Published: December 2023

AbstractThe purpose of this study was to comprehensively appraise and synthesize studies on hand hygiene practices among primary and secondary school students in sub-Saharan Africa (SSA). This is a thorough review of scientific papers published between 2015 and 2023 from primary databases such as the Web of Science, Science Direct, PubMed, and Google Scholar. The review criteria were met by 26 out of 63 studies assessed for legibility. The review demonstrated that students in SSA had moderate and good hand washing practices in terms of regular hand washing, cleaning hands after defecation, and before and after eating. Furthermore, the review pinpoints hand washing practices as influenced by factors such as knowledge, hand washing facilities and materials, influences from parents and teachers or others, personal and social factors, media, gender, age, and other factors such as location, attitudes, and school modernity. Furthermore, the reviewed studies highlighted recommendations for improving hand hygiene practices, such as enhancing hand hygiene and environmental health education, mobilizing resources for hand washing, creating and implementing health policy, and conducting further studies. This review provides data for policymakers on how to improve student hand hygiene and adds to existing knowledge on hand hygiene practices.
Discovery of Tropomyosin Receptor Kinase Inhibitors as New Generation
Anticancer Agents: A Review
Authors: Panchal Ishan , Tripathi Rati Kailash Prasad , Parmar Kinjal , Yadav Mange Ram 
Published: December 2023

Background::
The tropomyosin receptor kinases (TRKs) are crucial for many cellular functions, such as growth, motility, differentiation, and metabolism. Abnormal TRK signalling contributes to a variety of human disorders, most evidently cancer. Comprehensive genomic stud-ies have found numerous changes in the genes that code for TRKs like MET, HER2/ErbB2, and EGFR, among many others. Precision medicine resistance, relapse occurring because of the pro-tein point mutations, and the existence of multiple molecular feedback loops are significant thera-peutic hurdles to the long-term effectiveness of TRK inhibitors as general therapeutic agents for the treatment of cancer.

Objective::
This review is carried out to highlight the role of tropomyosin receptor kinase in can-cer and the function of TRK inhibitors in the intervention of cancer.

Methods::
Literature research has been accomplished using Google Scholar and databases like ScienceDirect, WOS, PubMed, SciFinder, and Scopus.

Results::
In this review, we provide an overview of the main molecular and functional properties of TRKs and their inhibitors. It also discusses how these advancements have affected the devel-opment and use of novel treatments for malignancies and other conditions caused by activated TRKs. Several therapeutic strategies, including the discovery and development of small-molecule TRK inhibitors belonging to various chemical classes and their activity, as well as selectivity to-wards the receptors, have been discussed in detail.

Conclusion::
This review will help the researchers gain a fundamental understanding of TRKs, how this protein family works, and the ways to create chemical moieties, such as TRK inhibitors, which can serve as tailored therapies for cancer.
Implementing a Complete Method of Eco-Design, Optimization, and
Sustainability in Automotive Mirrors
Authors: Ourihi Reda , El Hilali Fatima Zohra , Fihri-Fassi Hicham 
Published: December 2023

Introduction:
This article explores a novel approach to developing an environmentally
friendly structure through the implementation of eco-design, optimization, and sustainability. The
process consists of three key steps.

Methods:
Firstly, it begins with an understanding of eco-design principles aimed at enhancing the
structure's durability by selecting relevant environmental aspects and design guidelines. Secondly,
computer-aided design and optimization techniques are employed to identify efficient models, focusing
specifically on lightweight structures. Lastly, the article discusses two different processes, namely
injection molding and die casting, which can be used to minimize the environmental impact of the
structure.

Results:
The article emphasizes the significance of eco-friendly design in promoting sustainability
within the automotive industry.

Conclusion:
To validate these concepts, the study focuses on vehicle mirrors, which play a crucial
role in improving driver visibility, safety, and situational awareness during driving, maneuvering, and
parking.
The Transformative Impact of AI and Machine Learning on Human
Psychology
Authors: Jyoti Amrita , Yadav Vikash , Pal Amita , Rahul Mayur , Jha Sonu Kumar 
Published: December 2023

Abstract:
This journal paper examines the transformative role of Artificial Intelligence (AI)
and Machine Learning (ML) in shaping human psychology. It investigates how cognitive processes,
emotional states, and social interactions are impacted by AI and ML technology. The
use of AI and ML in psychology is covered in this study, covering social behaviour analysis,
emotion identification, mental health assessment, and personalised therapies. It also explores
the moral issues and prospective effects of AI and ML in comprehending and influencing human
psychology. This paper emphasises the enormous influence of AI and ML on the comprehension
and research of human psychology through a thorough analysis of pertinent literature
and empirical evidence. This paper seeks to offer a thorough explanation of the profound effects
that AI and ML have had on psychology. We will offer insight into the possible advantages,
difficulties, and ethical issues that occur when integrating AI and ML into the study
of human psychology by looking at recent developments and implementations of these technologies
in psychological research. We will also look at how other areas of psychology, such
as cognitive psychology, clinical psychology, social psychology, and neurology, have been
impacted by AI and ML.
Artificial Intelligence in Pharmaceutical Industry: Revolutionizing Drug
Development and Delivery
Authors: Bhatt Pankaj , Singh Suruchi , Kumar Vipin , Nagarajan Kandasamy , Mishra Shardandu Kumar , Kumar Dixit Praveen , Kumar Vinay , Kumar Sanjeev 
Published: December 2023

Abstract:
Artificial Intelligence (AI) has ushered in a profound revolution within the pharmaceutical
sector, effectively streamlining the processes of drug development and delivery. The application of
AI-driven tools and methodologies, including machine learning and natural language processing, in
the realm of pharmaceutical research and development has yielded recent breakthroughs. This accelerated
the drug discovery process by meticulously scrutinizing copious data and pinpointing potential
drug targets, as expounded upon in this comprehensive review. Furthermore, AI has found utility in
optimizing clinical trials, thereby refining trial designs and cost-effectiveness and bolstering patient
safety. Notably, AI-based strategies are being harnessed to enhance drug delivery, fostering the creation
of intelligent drug delivery systems engineered to target specific cells or organs. This results in
heightened efficacy and a concomitant reduction in undesirable side effects. This review also delves
into the potential biases residing within AI algorithms and the challenges associated with data quality
when integrating AI into the pharmaceutical sphere. The findings of this study underscore the immense
potential of artificial intelligence in reshaping the pharmaceutical industry, thereby enhancing
the quality of life for patients worldwide.
Media Sosial Instagram Dan Website Terhadap Minat Kunjung Wisatawan
Authors: Aji Cahyono , Andadari Roos Kities 
Published: December 2023

Fenomena yang terjadi saat ini adalah terjadinya perubahan terhadap aktifitas kehidupan manusia yang mengarah pada hal-hal yang serba digital. Hal ini yang melatarbelakangi penelitian ini, sehingga tujuan dari penelitian ini untuk menganalisis pengaruh variabel media sosial instagram dan website terhadap minat kunjung wisatawan. Metode penelitian yang digunakan adalah penelitian kuantitatif data primer berupa kuesioner yang didistribusikan menggunakan google form. Sampel yang digunakan sebesar 150 responden yang memiliki niat untuk melakukan kunjungan ke wisata Malioboro. Data dianalisis menggunakan uji regresi linear berganda yang diolah dengan program software SPSS. Hasil penelitian menunjukkan nilai signifikansi masing-masing variabel adalah sama sebesar 0.000 < 0.05. Determinasi (R2) sebesar 0.366, artinya variabel independent penelitian mampu menjelaskan hubungan terhadap variabel dependen sebesar 36.6% dan sisanya dipengaruhi oleh variabel lain di luar penelitian. sehingga dapat disimpulkan bahwa media sosial instagram dan website berpengaruh terhadap minat kunjung wisatawan.
The Rights and Status of Widows in Islam: A Study from the Perspective of Multicultural Islamic Education in the Context of Bangladesh
Authors: Mahmudulhassan M , Waston W , Nirwana AN Andri 
Published: December 2023

One of the most discussed topics in today’s society is the issue of widows’ proper rights and status. This research paper investigates the rights and status of widows within the framework of Islamic education in the context of Bangladesh using qualitative methods. It included the Qur’an, Hadith, and various forms of research. Islam has given them a detailed discussion of their rights and dignity just like any other woman. Widows often face unique challenges and social stigmatization in various societies, and this study focuses on understanding their rights and status as prescribed by Islamic teachings and the extent to which these teachings are implemented within the realm of Islamic education. Bangladesh government has fixed some allowance for them which is very little. No steps have been taken to increase employment to make them economically prosperous. This paper contributes to the ongoing discourse on women’s rights within an Islamic context and highlights the significance of integrating such discussions within the education system for tangible societal transformation.
Numerical and experimental analysis of the notch effect on fatigue behavior of polymethylmethacrylate metal based on strain energy density method and the extended finite element method
Authors: Moussaoui Mustafa , Bendriss Abdelkhader , Tahiri Antar , Kellai Ahmed , Zergod Souad , Djeloud Hamza , Hachi Brahim Kalil 
Published: December 2023

Abstract
This work investigates the effect of the notch on fatigue behavior by combining two methods: the extended finite element method (XFEM) and the averaged strain energy density (ASED) method, which considers the combined action of bending and shear loading. The ASED method has already been proven accurate for assessing the failure of components in the presence of sharp and blunt notches, and several results are available in the literature for different materials. These results were compared with those obtained from the experimental tests reported here. The main purpose of this study was twofold: The first part is an experimental study of fatigue in rotary bending of specimens weakened by U and V notches made of polymethyl-methacrylate (PMMA) material. Two values for the radius were used for the U-notches (0.2 and 2 mm) and two angles for the V-notches (20° and 140°). The second part of the study consisted of performing several simulation tests using the Cast3m software for different angles and radii. The local approach based on the mean value of the ASED acted over a finite-sized volume surrounding the highly stressed regions. The maximum principal stress located at the notch edge defined the center of the control volume. If the notch is blunt, the control volume assumes a crescent shape with its width measured along the notch bisector line. When the notch is considered pointed (V-notched) or is a crack, the control volume becomes a circle with its center at the notch tip. The presence of geometric discontinuities in structures affects their lifetime by reducing it, producing a high concentration of local energy around the notch tip. Good convergence was obtained between the numerical simulation and experimental results for the ASED in a finished zone surrounding the notch tip.
Surfers’ myelopathy: a case report
Authors: Zelada-Ríos Laura , Caparó-Zamalloa César , Guevara-Silva Erik , Osorio-Marcatinco Víctor , Castro-Suárez Sheila , Meza-Vega María 
Published: December 2023

Background:
As surfing gains adherents, the injuries derived from its practice become more frequent, one of which is the so-called surfer’s myelopathy (SM).

Case Presentation:
We present the case of a patient with an abrupt onset of mild back-lumbar pain, followed by paresthesia and motor involvement of both lower limbs as well as sphincter disturbance in the context of the immediate practice of an aquatic sport. Thoracic spinal cord magnetic resonance imaging showed T2 hyperintensities in the central part of the spinal cord between T8 and T12. SM is a nontraumatic spinal cord injury, of vascular etiology, caused by the prolonged hyperextension of the spine.

Conclusion:
The importance of this work lies in being one of the few in Peru addressing this pathology and the need for awareness for taking preventive measures by young athletes.
Design, Synthesis, Molecular Docking, Antitubercular, Antimicrobial and Antioxidant Studies of Some Novel 3-(((1H-Benzo[d]imidazol-2-yl)methyl)thio)-5H-[1,2,4] Triazino[5,6-b]indole Derivatives
Authors: Kamera Sreelatha , Sharma Vishnu Kumar , M Srivani , Garlapati Achaiah 
Published: December 2023

A series of novel 3-(((1H-benzo[d]imidazol-2-yl)methyl)thio)-5H-[1,2,4]triazino[5,6-b]indole derivatives (3a-3j) were synthesized by reacting different substituted 5H-[1,2,4]triazino[5,6-b]indole-3-thiols with substituted (2-chloromethyl)-1H-benzo(d)imidazoles in the presence of KOH and water in good yields. The structures of the newly synthesized compounds were confirmed by spectroscopic techniques such as 1H-NMR, 13C-NMR, IR and mass spectrometry. The in vitro antitubercular activity of the synthesized compounds was evaluated against Mycobacterium tuberculosis (Mtb) H37Rv (ATCC 27294) using MABA (Microplate Alamar Blue Assay) method. Compounds 3b, 3c, and 3i showed good antitubercular activity against Mtb with MIC value of 6.25±0.00 μg/ml. Also, the in vitro antimicrobial activities of the compounds were evaluated against various bacterial and fungal strains using the two-fold serial dilution technique and most of the compounds exhibited moderate activities with MIC values in the range of 63.33±1.44 to >500
Computer-Assisted Design of benzoisoxazol derivatives inhibitors of Bromodomain-containing protein 4 (BRD4) with Favorable Pharmacokinetic Profile
Authors: KOUADJA Rika Justin , MOUSSE Logbo Mathias , KOUMAN Koffi Charles , NSANGOU Mama , MEGNASSAN EUGENE 
Published: December 2023

We performed a Relation Computed-Aided design based on the structure of benzo[d]isoxazol derivatives inhibitors (BDIO) derivatives, new potent inhibitors of the BRD4 protein. By using in situ modifications of the three Dimensional (3D) models of BRD4-BDIOx complex (Protein Data Bank (PDB) entry code: 5Y8Z) were prepared for the training and validation sets compounds of 29 BDIOx with observed inhibitory potencies (). We first built a Quantitative Structure Activity Relationship (QSAR) model in the gas phase, linearly correlating the calculated enthalpies of the BRD4-BDIOx complex formation with ( ; = 0,80) first and then a superior QSAR model was brought forth, correlating computed relative Gibbs’ free energies of complexation and ( = -0.1205 + 6.9374 ; = 0.96) which was then validated by a 3D-QSAR pharmacophore generation model (PH4) ( = 0.996 + 0.0554 ; = 0.95). The structural information of the active conformation of the training set BDIOs from the models guided us in the design of a virtual combinatorial library (VCL) of 99 225 analogs. We then filtered the VCL by applying Lipinski’s rule-of-five, in order to identify new BDIOs drug likely analogs. The Pharmacophore (PH4)-based screening retained 106 new and potent BDIOs with predicted inhibitory potencies up to 158 times more active than the most active traing set BDIO1 ( ). Finally, the predicted pharmacokinetic profiles of the best potent of these new analogs ( ) were compared to current orally administered anticancer drugs. This computational approach, which combines molecular mechanics and the Poisson–Boltzmann (PB) implicit solvation theory, the pharmacophore model, the analysis of BRD4-BDIOs interaction energies, the in silico screening of VCL compounds, and the inference of ADME properties resulted in a set of new suggested BRD4 inhibitors for the fight against CRPC.
A Quantitative Approach for the Determination of Elemental Impurities in Zinc Orotate Dihydrate Drug Substance by ICP-MS Method
Authors: B Sivagami , G Gurupriya , Raju Chandasekar , M Niranjan Babu 
Published: December 2023

These days elemental impurities are commonly present in active pharmaceutical ingredients, raw materials, during synthesis of compounds, drug excipients, finished products, equipment, container and closures. ICPMS is one of the advanced techniques to analyse elemental impurities in drug substances. An ICP-MS method was developed and validated for testing 17 elements, namely, V, Co, Ni, As, Se, Ru, Rh, Pd, Ag, Cd, Os, Ir, Pt, Au, Hg, Tl and Pb in zinc orotate dihydrate. The samples were analysed after diluting with concentrated nitric acid and concentrated hydrochloric acid. Li, Y, Tl, Co & Ce were assigned tuning solution to correct the baseline drift and matrix interference. The RF power was 1550 W, RF matching was 1.80 V, sample depth was 8.0 mm, nebulizer gas flow was 1.01 L/min, nebulizer pump flow was 0.10 rps, spray chamber temperature 2o C, He flow rate was 4.3 ml/min and the energy discrimination rate was 3.0 V. All 17 elements exhibited excellent linearity in their testing range, with a coefficient of determination ≥ 0.9996. The limits of detection of the 17 elements were within the range of 0.0004–0.00411ppm. The intra- and inter-day precision (relative standard deviation) was < 6.4%. The recoveries of the spiked standard for all elements were 88.5–108.2%. Among the17 elements of the zinc orotate dihydrate, the measured results of all the 17 elements were within the specified range, and the results of the all the elements were also satisfactory. The developed method was simple, rapid, and effective. This method can be a powerful tool and imperative technology for the quantification of compounds in drug substances and pharmaceutical industries.
MERCURY CONTENT IN THE MUSCLE TISSUE OF FISH IN THE ESTUARY OF THE RED RIVER (VIETNAM)
Authors: Нгуен Т.Т.Н. , Волкова И.В. 
Published: December 2023

Целью работы являлось определение уровня содержания ртути в мышечной ткани рыб устьевой области реки Красная в соответствии с их массой, районам обитания и типом питания. Исследование проводилось на реке Красная и ее водотоках устьевой области реки Красная в течение 2016-2021 гг. в период основных гидрологических сезонов (в период летнего половодья и зимней межени). Даны зависимости содержания ртути в мышечной ткани рыб от их массы, объектов питания и трофического положения в пищевой цепи. Ведущую роль в накоплении ртути в теле рыб играет тип питания. Показано, что в трофической сети экосистемы устьевой области реки Красная на более высоком трофическом уровне пищевой цепи уровень аккумуляции ртути был выше. Хищники характеризуются более интенсивным накоплением ртути (в 4-13 раз) в мышечной ткани по сравнению с мирными видами рыб. Наибольшие концентрации ртути в мышечной ткани были зафиксированы у хищников (0,851±0,105 мг/кг у пресноводного сома Clarias batrachus). Установлено превышение концентрации ртути в мышечной ткани змееголовова (Chama. Striata) и пресноводного сома (Clarias batrachus) в 1,3-1,85 раз по сравнению с нормой, установленной во Вьетнаме.
The aim of the work was to determine the levels of mercury in the muscle tissue offish in the estuary of the Red River in accordance with their mass, habitat and type of food. The study was conducted on the Red River and its watercourses in the estuary of the Red River during 2016-2021 years in the main hydrological seasons (the summer flood and winter low water). The dependences of the mercury content in the muscle tissue offish on their mass, food objects and trophic position in the food chain are given. The type offood plays a leading role in the accumulation of mercury in the body offish. It was shown that in the trophic of the ecosystem in the estuary of the Red River at a higher trophic level of the food chain, the level of mercury accumulation was higher. Predators contribute to a more intense accumulation of mercury (4-13 times) in muscle tissue compared to peaceful fish species. The highest concentrations of mercury in muscle tissue were recorded in predators (0,851±0,105 mg/kg in Walking Catfish Clarias batrachus). An excess of the concentration of mercury in the muscle tissue of the striped snakehead (Channa Striata) and Walking Catfish (Clarias batrachus) in 1,3-1,85 times compared to the norm in Vietnam.