bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatic Analysis of Gastrointestinal Stromal Tumor: A Comprehensive Report
Authors: Wang Wenshu , Li Chao , Zhu Yuanmin 
Published: November 2023

Abstract
Background
An increasing number of asymptomatic gastrointestinal stromal tumor (GIST) patients are being identified. The objective of this study was to examine the association between necroptosis-related genes and high-risk GIST, providing data to inform the treatment and follow-up guidelines of asymptomatic patients.
Methods
The GIST dataset was acquired and by analyzing the dataset of GIST patients in high-risk and low-risk groups, we identified differentially expressed genes (DEGs). We constructed a diagnostic model and used it to analyze the screened DEGs in order to identify key genes involved in GIST. We then constructed mRNA-miRNA and mRNA-TF interaction networks to predict the interaction networks of key genes. We employed immune infiltration analysis to examine the correlation between immune cells and key genes.
Results
A total of 15 necroptosis-related DEGs were identified by analyzing the datasets of high and low-risk GIST patients. A diagnostic model was developed utilizing five essential genes (CAPN1, DNM1L, H2AFZ, MYC, and UCHL1) for discriminating high-risk and low-risk for GIST. The key gene MYC exhibited the highest level of interaction with miRNA, while the key gene CAPN1 displayed the most interactions with TFs. Immune infiltration analysis showed that the key gene MYC has a significant positive correlation with eosinophils and memory B cells.
Conclusion
The key genes MYC and CAPN1 may play crucial roles in the progression of GIST disease.
A new hyperchaotic system with dynamical analysis and its application in image encryption based on STM32
Authors: Cheng XueFeng , Zhu HongMei , Liu Juan 
Published: November 2023

Abstract
This paper proposes a new 4D hyperchaotic system based on a modified 3D Lorenz chaotic system. The stability of equilibrium points in this hyperchaotic system is analyzed, with a notable feature being the presence of only one equilibrium point. Subsequently, dynamic characteristics of the new system, such as Lyapunov exponents' spectrum, bifurcation diagram, and chaotic attractors, are analyzed using MATLAB numerical simulation software. The numerical analysis indicates that the hyperchaotic system exhibits hyperchaotic characteristics over a wide range of parameter d values, and its chaotic attractor manifests four states: hyperchaotic, chaotic, periodic, and quasi-periodic. This illustrates the complex dynamic behavior of the hyperchaotic system. Experimental validation is then conducted using embedded hardware STM32, reproducing the four types of chaotic attractors observed in numerical analysis and confirming the accuracy of theoretical analysis. The proposed new hyperchaotic system is deemed effective and reliable. Finally, the system is applied to image encryption, presenting a novel encryption method based on the hyperchaotic system. The designed hyperchaotic encryption sequence satisfies 15 tests of the NIST SP800-22 standard, and experimental verification using STM32 demonstrates the effectiveness, simplicity, non-linearity, and high security of the proposed image encryption algorithm. This method can be extended to applications such as audio encryption, image encryption, video encryption, and other fields.
Contribution of iron group metals to graphitic-structure formation in carbonization of woody biomass
Authors: Yamagishi Takayuki , Shibutani Sakae , Suzuki Hikaru , Yamauchi Shigeru 
Published: November 2023

Abstract

To evaluate the contribution of iron group metals to the formation of graphitic structures in woody charcoal, charcoal samples synthesized from Japanese cedar wood impregnated with 3d-transition metal (Cr, Mn, Fe, Co, Ni, Cu, Zn) ions were analyzed using microscopic Raman spectroscopy and powder X-ray diffractometry. The metal-loaded charcoal samples were carbonized at 650, 700, 750, 800, and 850°C in downstream N2 gas. The Gˊ-band, which shows the structural ordering of carbon atoms, was observed in the Raman spectra of Fe-, Co-, and Ni-loaded charcoal. The Gˊ-band position tended to shift to higher wavenumbers (2700‒2690 cm− 1) with increasing carbonization temperature. The Gˊ-band occurring in the 2700–2690 cm− 1 range corresponded to an X-ray diffraction (XRD) peak at ~ 26.3 ° assigned to the (002) plane of graphite-like structures. The high-wavenumber Gˊ-band also corresponded to the XRD detection of the carbide of the three metals. However, the XRD peak was not found for Co- and Ni-loaded charcoal samples exhibiting Gˊ-bands at ≤ 2670 cm− 1.
The Disease-specific Survival From Plasma Il-1 and Il-6 Families Cytokines With Associated Soluble Receptors at Diagnosis in Patients With Head and Neck Squamous Cell Carcinoma Importance of Tnm Stage and Smoking History
Authors: Aarstad Helene Hersvik , Moe Svein Erik Emblem , Lybak Stein , Bruserud Øystein , Tvedt Tor Henrik , Aarstad Hans Jørgen 
Published: November 2023

Abstract

The acute-phase cascade (APC) has been correlated with outcome in many different cancers, including head and neck squamous cell carcinoma (HNSCC). A main driver of the APC are the cytokines in the IL-6, IL-1 and TNF cytokine families. We have studied the systemic acute phase soluble cytokine/cytokine receptor profiles in serum (s) for patients with HNSCC. Systemic levels the of Interleukin-6 family cytokines/s-receptors (IL-6, IL-27, IL-31, OSM, CNTF, gp130,IL-6Rα), IL-1 family members (IL-1RA, IL-33Rα/ST2) and TNF-α at diagnosis from 144 HNSCC patients. Five-year disease-specific survival (DSS) was then studied. Increased levels of CRP (p < .001), IL-6 (p < .001), IL-31 (p = .044), IL-1RA (p = .004), IL-6Rα (p = .022) and gp130 (p = .007) were predictors among human papilloma virus (HPV) infection negative (−) patients. Only the IL-6 levels predicted DSS among HPV positive (+) patients. High TNF-α levels showed a trend toward predicting DSS (p = .078) when considering all patients and adjusted for HPV. Adjusting for TNM stage and smoking history, IL-6Rα, gp130, and IL-33Rα/ST2 retained DSS survival prediction. Factor analysis suggests two underlying factors for the present results. The first factor contains the cytokines and the second contains the soluble cytokine receptors. To conclude: High serum levels of IL-6, IL-31 and IL-1RA as well as the soluble receptors IL-6Rα and gp130, and to some extent TNF-α at the time of diagnosis predicted lowered DSS. Clinically, IL-6 levels above 2.5 pg/ml yielded more than 70% specificity and sensitivity for DSS. The cytokine predictions were associated with TNM stage and smoking history, whereas IL-6Rα, gp130 and IL-33Rα/ST2 levels predicted DSS more uniquely.
Statistical method of multi-omics data integration and its application in cancer analysis
Authors: Jiao Yunmeng , Chang Zhiyong 
Published: November 2023

Abstract
With the advancements in science and technology, the study of cancer has expanded beyond analyzing a single set of data. Instead, researchers are now focusing on the fusion analysis of multiple data groups, which is more beneficial for predicting cancer. I This research paper examines the existing techniques for analyzing multi-omics data through statistical integration. The methods discussed include correlation analysis, multivariate analysis, and series integration analysis. However, as high-throughput sequencing technology advances, multi-omics data sets have become increasingly large. This leads to a "dimensional disaster" where traditional analysis methods struggle to effectively extract relevant variables and are prone to overfitting and failure. This paper introduces a method called sparse canonical correlation analysis, which is used to analyze the data set of DNA methylation and RNA-seq gene expression in breast cancer patients. The relationship between the methylation status of particular DNA regions and the level of gene expression was examined, and the most significant characteristics in each dataset were identified. This approach offers a novel method for complex multi-omics datasets with high dimensionality.
Impact of Pulse Pressure on Acute Brain Injury in Venoarterial ECMO Patients with Cardiogenic Shock During the First 24 Hours of ECMO Cannulation: Analysis of the Extracorporeal Life Support Organization Registry
Authors: Kalra Andrew , Kang Jin Kook , Wilcox Christopher , Brown Patricia , Rycus Peter , Anders Marc M , Zaaqoq Akram M , Brodie Daniel , Whitman Glenn J R , Cho Sung-Min 
Published: November 2023

Abstract

Background: Low pulse pressure (PP) in venoarterial-extracorporeal membrane oxygenation (VA-ECMO) is a marker of cardiac dysfunction and has been associated with acute brain injury (ABI) as continuous-flow centrifugal pump may lead to endothelial dysregulation.
Methods: We retrospectively analyzed adults (≥18 years) on “peripheral” VA-ECMO support for cardiogenic shock in the Extracorporeal Life Support Organization Registry (1/2018-7/2023). Cubic splines were used to establish a threshold (PP≤10 mmHg at 24 hours of ECMO support) for “early low” PP. ABI included central nervous system (CNS) ischemia, intracranial hemorrhage, brain death, and seizures. Multivariable logistic regressions were performed to examine whether PP≤10 mmHg was associated with ABI. Covariates included age, sex, body mass index, pre-ECMO variables (temporary mechanical support, vasopressors, cardiac arrest), on-ECMO variables (pH, PaO2, PaCO2), and on-ECMO complications (hemolysis, arrhythmia, renal replacement therapy).
Results: Of 9,807 peripheral VA-ECMO patients (median age=57.4 years, 67% male), 8,294 (85%) had PP>10 mmHg vs. 1,513 (15%) had PP≤10 mmHg. Patients with PP≤10 mmHg experienced ABI more frequently vs. PP>10 mmHg (15% vs. 11%, p<0.001). After adjustment, PP≤10 mmHg was independently associated with ABI (adjusted odds ratio [aOR]=1.25, 95% confidence interval [CI]=1.06-1.48, p=0.01). CNS ischemia and brain death were more common in patients with PP≤10 mmHg vs. PP>10 mmHg (8% vs. 6%, p=0.008; 3% vs. 1%, p<0.001). PP≤10 mmHg was associated with CNS ischemia (aOR=1.26, 95%CI=1.02-1.56, p=0.03) but not intracranial hemorrhage (aOR=1.14, 95%CI=0.85-1.54, p=0.38).
Conclusions: Early low PP (≤10 mmHg) at 24 hours of ECMO support was associated with ABI, particularly CNS ischemia, in peripheral VA-ECMO patients.
Assessing the impact of an arch-dam breach magnitude and reservoir inflow on flood maps
Authors: Gogoașe Nistoran Daniela Elena , Ionescu Cristina Sorana , Simionescu Ștefan Mugur 
Published: November 2023

Abstract
Different scenarios of an arch-dam breach and their impact on the time-space evolution of flood waves are analysed using numerical modelling. As the accidents involving this type of dam are among the most catastrophic ones, the 108 m in height Paltinu arch-dam, Romania, was chosen as a case study due to its problems in the past. Three dam breach magnitudes and two inflow hydrographs for the worst-case scenario of Normal Operating Pool elevation in the reservoir were chosen as variable parameters, to assess their influence on the dam break wave characteristics and downstream flooded areas. The flood was routed along the 18 km reach of the Doftana River down to the confluence with the Prahova River. A 2D numerical model was set up with the help of HEC-RAS software, which was also used to analyse the resulting hazard maps under a GIS environment. Comparison of inundation boundary, maximum depths and velocities, as well as the arrival time at control sections allow for conclusions to be drawn. These predictive results of shape, magnitude, and time to peak of the flood waves are essential for flood risk management to obtain the risk maps, estimated damage costs, and possible affected areas.
Insights into karst groundwater hydrogeochemical characteristics and spatial evolution in the Jinan karst aquifer system, northern China
Authors: Liu Dan , Tian Chanjuan , Chen Xuequn , Zhang Wenjing , Zhang Xin , Wang Zezheng , Xu Dandan , Chang Yawen 
Published: November 2023

Abstract
Karst aquifers are strategically important as they supply domestic water and are a resource for irrigation and industry in northern China. The heterogeneity of the karst aquifer medium makes it vulnerable to external influences. Here, samples of surface water and groundwater in a typical karst groundwater system of Jinan (China) were collected in December 2021, and the sample data were analyzed to further elucidate the hydrogeochemical processes. Results showed that the predominant water chemical type is HCO3-Ca, with a lesser proportion of type HCO3·SO4-Ca and SO4-Ca. The dominant water–rock interactions comprise the dissolution of carbonate minerals, gypsum, and halite and ion exchange. Dissolution/precipitation of calcite, dolomite, and gypsum determines the concentrations of Ca2+, Mg2+, HCO3-, and SO42-. In terms of spatial distribution, the indirect and direct recharge areas are dominated by calcite dissolution, followed by dolomite dissolution, and are prone to ion exchange. The hydrogeochemical formation mechanism of the discharge area is more complicated by other hydrochemical processes and anthropogenic activities. These results provide guidance for global karst groundwater resource management and pollution prevention.
Hydrodynamic cavitation-enhanced activation of sodium percarbonate for estrogen removal
Authors: Odehnalová Klára , Přibilová Petra , Maršálková Eliška , Zezulka Štěpán , Pochylý František , Rudolf Pavel , Maršálek Blahoslav 
Published: November 2023

Abstract

The present paper investigated the potential of hydrodynamic cavitation (HC) as an effective tool for activating sodium percarbonate (SPC). The method's efficiency was demonstrated by effectively removing estrogens, which are pollutants that have adverse impacts on aquatic ecosystems. The effects of the SPC concentration, temperature of solution, and cavitation time were evaluated. After SPC/HC treatment, the removal of estrogens was monitored by liquid chromatography-tandem mass spectrometry (LC -MS/MS). Already after 4 s of treatment and 24 h of reaction time, more than 97% of estrogens (initial concentration of 300 ng/L) were removed. The effect of post-treatment time is not considered in several papers, even though it seems to be crucial and is discussed here. The results were supported by the values of degradation rate constants, which fit the pseudo-first-order kinetic model. We also verified that HC alone was not effective for estrogen removal under the selected conditions. The sustainability of the SPC/HC system was evaluated based on electric energy per order calculation. The combination of SPC and HC is a promising approach for rapidly degrading micropollutants such as estrogenic compounds without the need for additional technological steps, such as pH or temperature adjustment.
Risk Perception, Acceptance, and Trust of Using AI in Gastroenterology Practice in the Asia-Pacific Region: Web-Based Survey Study
Authors: Goh Wilson WB , Chia Kendrick YA , Cheung Max FK , Kee Kalya M , Lwin May O , Schulz Peter J , Chen Minhu , Wu Kaichun , Ng Simon SM , Lui Rashid , Ang Tiing Leong , Yeoh Khay Guan , Chiu Han-mo , Wu Deng-chyang , Sung Joseph JY 
Published: November 2023

Background
The use of artificial intelligence (AI) can revolutionize health care, but this raises risk concerns. It is therefore crucial to understand how clinicians trust and accept AI technology. Gastroenterology, by its nature of being an image-based and intervention-heavy specialty, is an area where AI-assisted diagnosis and management can be applied extensively.

Objective
This study aimed to study how gastroenterologists or gastrointestinal surgeons accept and trust the use of AI in computer-aided detection (CADe), computer-aided characterization (CADx), and computer-aided intervention (CADi) of colorectal polyps in colonoscopy.

Methods
We conducted a web-based questionnaire from November 2022 to January 2023, involving 5 countries or areas in the Asia-Pacific region. The questionnaire included variables such as background and demography of users; intention to use AI, perceived risk; acceptance; and trust in AI-assisted detection, characterization, and intervention. We presented participants with 3 AI scenarios related to colonoscopy and the management of colorectal polyps. These scenarios reflect existing AI applications in colonoscopy, namely the detection of polyps (CADe), characterization of polyps (CADx), and AI-assisted polypectomy (CADi).

Results
In total, 165 gastroenterologists and gastrointestinal surgeons responded to a web-based survey using the structured questionnaire designed by experts in medical communications. Participants had a mean age of 44 (SD 9.65) years, were mostly male (n=116, 70.3%), and mostly worked in publicly funded hospitals (n=110, 66.67%). Participants reported relatively high exposure to AI, with 111 (67.27%) reporting having used AI for clinical diagnosis or treatment of digestive diseases. Gastroenterologists are highly interested to use AI in diagnosis but show different levels of reservations in risk prediction and acceptance of AI. Most participants (n=112, 72.72%) also expressed interest to use AI in their future practice. CADe was accepted by 83.03% (n=137) of respondents, CADx was accepted by 78.79% (n=130), and CADi was accepted by 72.12% (n=119). CADe and CADx were trusted by 85.45% (n=141) of respondents and CADi was trusted by 72.12% (n=119). There were no application-specific differences in risk perceptions, but more experienced clinicians gave lesser risk ratings.

Conclusions
Gastroenterologists reported overall high acceptance and trust levels of using AI-assisted colonoscopy in the management of colorectal polyps. However, this level of trust depends on the application scenario. Moreover, the relationship among risk perception, acceptance, and trust in using AI in gastroenterology practice is not straightforward.
TOPLUMSAL CİNSİYET ALGISI BAĞLAMINDA, ALIŞILMIŞIN DIŞINDA PERFORMANS SANATIYLA “ORLAN”
Authors: KORKMAZ Ayşe , BATUR Meral 
Published: November 2023

Değişen dünya ile birlikte geçmişte anaerkil işleyen sistem yerini ataerkil sisteme bırakmıştır. Bundan dolayı kadınlar, onların bedenleri üzerinde söz sahibi olduğuna hükmeden bu sistemin belirlediği normlar doğrultusunda güzelliğin peşinde koşmak zorunda bırakılmıştır. Kadını hali hazırda ikinci sınıf bir insan olarak gören eril düzen, güzel olmayana bunu bile layık görmemiş, böylece kadını estetik ameliyatların yanı sıra kozmetik dünyasının da sömürüsü hâline getirmiştir. Bu duruma “Dur!” diyen, feminist akımlarla yeniden inşa edilmeye çalışılan kadının kendi bedeni üzerinde söz sahibi olma düşüncesi video, enstalasyon ve performans çalışmaları gibi sanatın anlatım araçları ile her sanatçının kendi üslubu neticesinde yorumlanmaktadır.
Bu çalışmada, toplumsal cinsiyet rollerinin, sürekli değişen güzellik anlayışına kendi bedenini bir sanat aracı olarak kullanan Orlan’ın bedeninin sınırlarını nasıl aştığına, yorumladığına ve yaklaşım biçimine dair bir inceleme yapılmıştır. Bu çalışma araştırma niteliğinde olup, çalışmada literatür tarama yöntemi kullanılmıştır. Orlan’ın, kadınların uğruna katlanmış oldukları güzellik kavramının beden üzerindeki, operasyon sırası ve sonrası etkilerine dikkat çektiği, lokal anestezi yöntemiyle acıyı bertaraf ederek kendi bedeni üzerinde ancak kendisinin söz sahibi olabileceğinin mesajını verdiği; insan vücudunun değiştirilemez ya da dönüştürülemez olmadığı; sanatçının toplumdaki cinsel kimlik, kadın bedeni, estetik ve güzellik uğruna çekilen acı kavramlarını yeniden tanımladığı; bunun yanında özdenetim, kişisel hak ve özgürlük gibi kavramları sorguladığı sonucuna varılmıştır.
Pengalaman Perawat Dalam Melakukan Perawatan Luka Diabetik Selama Pademi COVID-19
Authors: Silalahi Rini Debora , Purba Jenny Marlindawani 
Published: November 2023

Pandemi COVID-19 menghambat praktik perawatan luka kaki diabetik sehingga dibutuhkan strategi baru yang aman untuk kelanjutan praktik klinis perawatan luka kaki diabetik selama pandemi COVID-19 agar perawatan luka tetap berlanjut. Pemberian perawatan dimodifikasi untuk untuk mencegah penyebaran COVID-19 dan mencegah resiko ulserasi kaki yang mengakibatkan infeksi lebih berat. Tujuan dari penelitian ini adalah untuk mengeksplorasi pengalaman perawatan luka sebelum dan selama pandemi COVID-19 di Kota Medan. Metode yang digunakan dalam penelitian ini merupakan penelitian kualitatif dengan pendekatan fenomenologi deskriptif. Pengambilan sampel menggunakan purposive sampling, yaitu 10 perawat luka. Adapun kriteria inklusi dalam penelitian meliputi perawat luka tersertifikasi CWCCA, Perawat dengan lulusan Ners, berpengalaman minimal 1 tahun dan bekerja di klinik perawatan luka selama pandemi COVID-19. Penelitian dilakukan di salah satu klinik perawatan luka di kota Medan. Hasil wawancara direkam terlebih dahulu, selanjutnya ditranskrip. Penelitian dianalisis dengan metode analisis Colaizzi. Hasil dari proses analisis tematik dalam penelitian ini didapatkan 6 tema, yaitu: kecemasan menghadapi pandemi COVID-19, dampak pandemi COVID-19 terhadap perawatan luka, hambatan perawatan luka di masa pandemi, strategi perawatan luka di masa pandemi, mekanisme koping perawat menghadapi pandemi, dan 6) dukungan sosial yang diperoleh perawat selama pandemi. Adapun kesimpulannya yaitu terjadi penundaan perawatan luka kaki diabetik akibat adanya pandemi COVID-19 sehingga menyebabkan jumlah kunjungan pasien luka kaki diabetik menurun dan mempengaruhi jumlah pendapatan perawat yang berkurang di masa pandemi COVID-19.
PRESENTEÍSMO NA EDUCAÇÃO SUPERIOR: UM ESTUDO NAS MODALIDADES GRADUAÇÃO, ESPECIALIZAÇÃO E MESTRADO
Authors: Costa Danilo de Melo , Oliveira Igor de , Andrade Rodrigo Mascarenhas Morato de , Paulo Marina Costa Cândido de , Silva Débora Aparecida Correa da 
Published: November 2023

Presenteísmo é o termo utilizado para descrever o estado em que o indivíduo está fisicamente presente em seu local de estudo ou trabalho, mas não está mentalmente focado em suas atividades. Desta forma, o presente artigo tem como objetivo identificar os principais aspectos que influenciam o comportamento presenteísta durante o processo de formação do aluno. Para tanto, foi aplicado um questionário para verificação do estado presenteísta a 386 alunos de uma instituição de ensino superior da região metropolitana de Belo Horizonte - Minas Gerais, nas modalidades de graduação, especialização e mestrado. Observou-se que o presenteísmo é um problema que atualmente acomete a comunidade discente, e que os fatores relacionados às necessidades biopsicossociais e ao universo acadêmico são os que possuem maior influência sobre o mesmo. Conclui-se então que o conhecimento dos fatores que predispõem ao presenteísmo a partir do instrumento aplicado é de extrema relevância para a melhoria contínua dos processos de ensino-aprendizagem nas instituições, bem como servirá de auxílio para que ações mitigatórias do presenteísmo discente sejam elaboradas e implementadas com maior assertividade.