bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of transamidation vs. fermentation to reduce the gluten content of the Triticum monococcum wheat cultivar Hammurabi: analysis of biochemical, baking and sensory parameters
Authors: De Sena Vincenzo , Mazzarella Giuseppe , Rossi Mauro 
Published: January 2024

SummaryThe Triticum monococcum cultivar Hammurabi has been considered a wheat with reduced gluten toxicity for intolerant people. To further reduce gluten toxicity, we tested two biotechnological treatments on Hammurabi flour, fermentation by endogenous microbiota and transamidation by microbial transglutaminase. After 1 day of fermentation, the detectable gluten content dropped to 51.4% ± 6.4% (R5‐ELISA). Interestingly, microbial hydrolysis did not change the content of the water‐insoluble gliadin fraction. Transamidation of Hammurabi caused a greater reduction of the native gluten to 33.5% ± 3.3% (P < 0.01) and changed its physical properties, as it became water soluble. Interestingly, only dough from transamidated Hammurabi flour could leaven, similarly to the untreated dough, while in fermented Hammurabi dough, the rising activity of the added yeast was inhibited. Baking analysis indicated no substantial difference between transamidated and untreated Hammurabi breads. Descriptive sensory analysis showed that darkness appearance parameters and texture parameters were significantly altered in transamidated bread. Importantly, the treatment did not influence wheaty flavour or cereal odour, two mainly expected organoleptic features. Our data may have important implications in the perspective of manufacturing innovative foods for people predisposed to or suffering from gluten intolerance.
Evolution of the urinary microbiota in spinal cord injury patients with decubitus ulcer: A snapshot study
Authors: Morsli Madjid , Salipante Florian , Gelis Anthony , Magnan Chloé , Guigon Ghislaine , Lavigne Jean‐Philippe , Sotto Albert , Dunyach‐Remy Catherine 
Published: January 2024

AbstractCurrent microbiome investigations of patients with pressure ulcers (PU) are mainly based on wound swabs and/or biopsy sequencing, leaving the colonization scenario unclear. Urinary microbiota has been never studied. As a part of the prospective ESCAFLOR study, we studied urinary microbiota of spinal cord injury (SCI) patients with PU without any urinary tract infection at the inclusion, collected at two times (at admission [D0] and after 28 days [D28]) during the patient's care, investigated by 16S rDNA metagenomics next generation sequencing. Subgroup analyses were carried out between patients with wounds showing improved evolution versus stagnated/worsened wounds at D28. Analysis was done using EPISEQ® 16S and R software. Among the 12 studied patients, the urinary microbiota of patients with improved wound evolution at D28 (n = 6) presented a significant decrease of microbial diversity. This modification was associated with the presence of Proteobacteria phylum and an increase of Escherichia‐Shigella (p = 0.005), as well as the presence of probiotic anaerobic bacteria Lactobacillus and Bifidobacterium. In contrast, Proteus abundance was significantly increased in urine of patients with stagnated/worsened wound evolution (n = 6) (p = 0.003). This study proposes urinary microbiota as a complementary factor indirectly associated with the wound evolution and patient cure. It opens new perspectives for further investigations based on multiple body microbiome comparison to describe the complete scenario of the transmission dynamics of wound‐colonizing microorganisms.
Evaluation of bevacizumab biosimilar on wound healing complications in patients with colorectal cancer undergoing endoscopic mucosal resection: A systematic review and meta‐analysis in anorectal medicine
Authors: Li Yixi , Mei Zhimou , Shi Liang , Wan Yin , Zhou Xiaoli , Zeng Ting , Liu Yi , Yang Jia Yao , Shi Zhaohong 
Published: January 2024

AbstractComplications related to wound healing pose substantial obstacle in the management of colorectal cancer (CRC), specifically in the field of anorectal medicine. Biosimilars of bevacizumab have emerged as crucial therapeutic agents in the management of these complications. With the particular emphasis on effects of Bevacizumab Biosimilar Plus on wound healing among patients diagnosed with CRC, this review underscores the potential of this anorectal medication to improve patient outcomes and was aimed to assess the safety and efficacy of Bevacizumab Biosimilar Plus in relation to complications associated with wound healing in patients with CRC. The assessment centers on its therapeutic potential and safety profile within the domain of anorectal medicine. In accordance with the PRISMA guidelines, a comprehensive literature search was performed, resulting in the identification of 19 pertinent studies out of an initial 918. Priority was given to assessing the safety and adverse effects of Bevacizumab Biosimilar Plus in conjunction with its effectiveness in wound healing. The extracted data comprised the following: study design, patient demographics, comprehensive treatment regimens, wound healing‐specific outcomes and adverse effects. The evaluation of study quality was conducted utilizing the instruments provided by the Cochrane Collaboration and the Newcastle‐Ottawa Scale (NOS). Bevacizumab Biosimilar Plus demonstrates efficacy in the management of wound healing complications among patients with CRC, with a safety and efficacy profile similar to that of the original Bevacizumab, according to the analysis. Notably, several studies reported improved rates of wound healing in relation to the biosimilar. The safety profiles exhibited similarities to the anticipated anti‐VEGF agent effects. In wound management, the biosimilar also demonstrated advantages in terms of prolonged efficacy. In addition, analyses of cost‐effectiveness suggested that the use of biosimilars could result in cost reductions. Bevacizumab Biosimilar Plus exhibited potential as an anorectal medication for the effective management of wound healing complications in patients with CRC. This has substantial ramifications for improving the quality of patient care, encompassing the affordability and effectiveness of treatments.
Bioanalytical evaluation of wound depth and musculoskeletal injuries: Synergizing focused assessment with sonography for trauma with computed tomography/magnetic resonance imaging in orthopaedic trauma care
Authors: Xue Zujun , Wen Bi 
Published: January 2024

AbstractOrthopaedic trauma care frequently necessitates prompt and precise assessment of musculoskeletal injuries and wound depth. The potential for improved diagnostic accuracy and patient outcomes exists with the integration of sophisticated imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) with focused assessment with sonography for trauma (FAST). The purpose of this research was to examine the benefits and drawbacks of this integrative method in the clinical environment. From June 2022 to September 2023, 250 patients who were admitted to Ningbo University Affiliated People's Hospital, participated in this cross‐sectional observational study. Following the administration of FAST, CT and MRI were utilized to evaluate orthopaedic injuries and skin wounds in patients. Analyses of data centred on the precision of diagnoses, the influence of treatment decisions and patient outcomes. Aged and gendered differently, the study participants sustained the variety of injuries and superficial wounds that were predominantly the result of traffic accidents. The FAST assay exhibited sensitivity of 65%, specificity of 80% and 72% overall accuracy. MRI demonstrated the finest diagnostic performance (85% sensitivity, 95% specificity and 89% accuracy), whereas CT scans offered improved diagnostic efficacy (80% sensitivity, 90% specificity and 84% accuracy). Treatment decisions were substantially impacted by integration of these imaging modalities, resulting in modifications in 20%–35% of cases, depending on the specific modality employed. Specifically, MRI played a pivotal role in informing treatment approaches, influencing non‐surgical as well as surgical procedures. This study substantiates the significant advantages of integrating FAST with CT and MRI in orthopaedic trauma care, particularly in the accurate assessment of wound depth. The synergistic use of these imaging techniques not only enhances diagnostic precision but also positively impacts treatment strategies and patient outcomes, emphasizing the need for a comprehensive diagnostic approach in trauma care settings.
RETRACTED: Risk predictions of surgical wound complications based on a machine learning algorithm: A systematic review
Authors: Zhang Hui , Zhao Junde , Farzan Ramyar , Alizadeh Otaghvar Hamidreza 
Published: January 2024

AbstractSurgical wounds may arise due to harm inflicted upon soft tissue during surgical intervention, and many complications and injuries may accompany them. These complications can lead to prolonged hospitalization and poorer clinical outcomes. Also, Machine learning (ML) is a Section of artificial intelligence (AI) that has emerged in medical care and is increasingly used for diagnosis, complications, prognosis and recurrence prediction. This study aims to investigate surgical wound risk predictions and management using a ML algorithm by R programming language analysis. The systematic review, following PRISMA guidelines, spanned electronic databases using search terms like ‘machine learning’, ‘surgical’ and ‘wound’. Inclusion criteria covered experimental studies from 1990 to the present on ML's application in surgical wound evaluation. Exclusion criteria included studies lacking full text, focusing on ML in all surgeries, neglecting wound assessment and duplications. Two authors rigorously assessed titles, abstracts and full texts, excluding reviews and guidelines. Ultimately, relevant articles were then analysed. The present study identified nine articles employing ML for surgical wound management. The analysis encompassed various surgical procedures, including Cardiothoracic, Caesarean total abdominal colectomy, Burn plastic surgery, facial plastic surgery, laparotomy, minimal invasive surgery, hernia repair and unspecified surgeries. ML was skillful in evaluating surgical site infections (SSI) in seven studies, while two extended its use to burn‐grade diagnosis and wound classification. Support Vector Machine (SVM) and Convolutional Neural Network (CNN) were the most utilized algorithms. ANN achieved a 96% accuracy in facial plastic surgery wound management. CNN demonstrated commendable accuracies in various surgeries, and SVM exhibited high accuracy in multiple surgeries and burn plastic surgery. In sum, these findings underscore ML's potential for significant improvements in postoperative management and the development of enhanced care techniques, particularly in surgical wound management.
A meta‐synthesis of the experience of paediatric nurses in communication with children
Authors: Sabetsarvestani Raheleh , Geçkil Emine 
Published: January 2024

AbstractAimThis study aimed to conduct a meta‐synthesis to explore the experiences of paediatric nurses in communication with children.MethodWe conducted a meta‐synthesis review, following the outline proposed by Sandelowski, Barrosso & Voils. Our search encompassed six electronic databases, namely PubMed, Scopus, EBSCO (MEDLINE), Web of Science, SAGE, and Wiley. The Primary keywords used were “nurse”, “child”, “communication”, and “qualitative”. We included qualitative articles in English within the field of paediatric nursing between 1990 and 2023. Initially, 1980 records were identified which reduced to 1339 references after removing duplicates. Subsequently, we assessed 112 full‐text articles for eligibility and 14 relevant studies were ultimately included in our review. Quality appraisal was conducted using the Critical Appraisal Skill Programme checklist with no study being excluded based on quality criteria. Data were synthesized using the qualitative thematic analysis method.ResultsThe data analysis yielded three themes and seven sub‐themes. These themes include swinging between triadic and dyadic communication, applying a hybrid of communication methods, and influential factor in communication.ConclusionsThis study highlighted the significance of establishing a balanced approach between dyadic communication (nurse and child) and triadic communication (nurse–parent–child) in paediatric care. Paediatric nurses emphasized the simultaneous use of verbal and non‐verbal methods to enhance effective communication. Additionally, identifying the influential factors in communication can aid in developing and improving nurses' competency in communication skills within paediatric departments.ImplicationsUnderstanding the communication process and the factors that influence it can be instrumental in equipping paediatric nurses with enhanced communication skills in their practice.Impact

Establishing a balanced approach between dyadic communication (nurse and child) and triadic communication (nurse–parent–child) in paediatric care is crucial.

Paediatric nurses emphasized the simultaneous use of verbal and non‐verbal methods to enhance effective communication.

Identifying the influential factors in communication can aid in developing and improving nurses' competency in communication skills within paediatric departments.
Post‐TAVR conduction abnormalities leading to permanent pacemaker implantation: Risk factors, prevention, and management
Authors: Ghazal Rachad , Garabedian Haroutioun , Sawaya Fadi , Refaat Marwan M. 
Published: January 2024

AbstractTranscatheter aortic valve replacement (TAVR) often leads to conduction abnormalities, necessitating pacemaker implantation. This review of 38 meta‐analyses identified preexisting right bundle branch block (RBBB), LAHB, and new‐onset left bundle branch block as key risk factors, with a higher PPM risk in male and older patients. Procedural factors like transfemoral access and self‐expandable valves also increase this risk. Prevention focuses on tailoring TAVR to individual electrophysiological and anatomical profiles. However, there's a lack of consensus in managing these conduction disturbances post‐TAVR, highlighting the need for further research and standardized treatment strategies.
Organizational Overlap and Bureaucratic Actors: How EU–NATO Relations Empower the European Commission
Authors: Hoeffler Catherine , Hofmann Stephanie C. 
Published: January 2024

AbstractOrganizational overlap is a ubiquitous feature in regional governance. Most studies have focused on member states, demonstrating that overlap enables states differently. We still know little about whether and how overlapping organizations impact international bureaucracies and how this shapes the relationship between bureaucratic actors within organizations. We argue that overlap can empower international bureaucrats, but not equally. Those with autonomous resources from member states are the most attractive interlocuters for bureaucrats from other organizations and, hence, likely to become most empowered. Substantive expertise and formal competence are less consequential in this context. We unpack this argument by looking at a policy domain understood to be heavily guarded by member states, security and defence policy. Based on primary documents and interviews, we show that the European Union (EU)–North Atlantic Treaty Organization (NATO) overlap has enabled the European Commission to leverage its position within the EU to its advantage and further encroach on the EU's security and defence activities.
Oral language enrichment in preschool improves children's language skills: a cluster randomised controlled trial
Authors: West Gillian , Lervåg Arne , Birchenough Julia M. H. , Korell Caroline , Rios Diaz Mariela , Duta Mihaela , Cripps Denise , Gardner Rachel , Fairhurst Caroline , Hulme Charles 
Published: January 2024

BackgroundOral language skills provide the foundation for formal education, yet many children enter school with language weaknesses. This study evaluated the efficacy of a new language enrichment programme, the Nuffield Early Language Intervention—Preschool (NELI Preschool), delivered to children in the year before they enter formal education.MethodsWe conducted a preregistered cluster randomised controlled trial in 65 nursery schools in England (https://doi.org/10.1186/ISRCTN29838552). NELI Preschool consists of a 20‐week whole‐class language enrichment programme delivered by a teacher each day for 20 min. In addition, children with the weakest language skills in each class are allocated to receive additional targeted support delivered by classroom assistants (whole‐class + targeted). The language skills of all children (n = 1,586) in participating classrooms were assessed using the LanguageScreen automated app (https://oxedandassessment.com/languagescreen/). Settings were then randomly allocated to an intervention or control group. The children with the weakest language in each class (whole‐class + targeted children n = 438), along with four randomly selected children in each class allocated to the whole‐class only programme (n = 288) were individually tested on a range of language measures.ResultsChildren receiving NELI Preschool made larger gains than children in the control group on an oral language latent variable (whole‐class children d = .26; whole‐class + targeted children d = .16).ConclusionsThis study provides good evidence that whole‐class intervention delivered in preschool can produce educationally significant improvements in children's language skills. The intervention is scaleable and relatively low cost. These findings have important implications for educational and social policy.
Comparison of efficacy and safety of insulin degludec/liraglutide and insulin glargine U‐100/lixisenatide in individuals with type 2 diabetes mellitus using professional continuous glucose monitoring
Authors: Kawaguchi Yuji , Hajika Yuriko , Rinka Maho , Masumoto Koji , Sawa Jun , Hamazaki Kenji , Kumeda Yasuro 
Published: January 2024

ABSTRACTAim/IntroductionInsulin glargine U100/lixisenatide and insulin degludec/liraglutide are fixed‐ratio combinations containing basal insulin and a glucagon‐like peptide‐1 receptor agonist capable of reducing both fasting and postprandial blood glucose levels with a single formulation. This study aimed to compare the time in range (TIR) and the time below range (TBR) level 1 using professional continuous glucose monitoring and to establish criteria for the differential use of the fixed‐ratio combinations.Materials and MethodsThirty‐six outpatients with type 2 diabetes mellitus (24 men and 12 women; average age, 62.1 years) were randomly assigned to the groups. At 0 and 18 weeks, a device was worn to compare the TIR and TBR level 1. The correlation between the C‐peptide index at baseline and TIR at 18 weeks was assessed.ResultsThe TIR and TBR level 1 showed no significant differences between the two groups. Both groups showed significant positive correlations between the C‐peptide index and the TIR (P = 0.002, r = 0.679; P = 0.002, r = 0.681, respectively). The changes in glycemic variability, therapeutic indices, and body mass index were not significantly different among the groups (P > 0.05). The receiver operating curve analysis revealed that the cut‐off values of the C‐peptide index to achieve TIR of >70% at 18 weeks were 1.258 (sensitivity, 77.8%; specificity, 100%) and 1.099 (sensitivity, 57.1%; specificity, 90.9%) in the insulin glargine U100/lixisenatide and insulin degludec/liraglutide groups, respectively.ConclusionsA TIR of >70% was achieved for both fixed‐ratio combinations without significant differences.
Treponema pallidum protein Tp47 induced prostaglandin E2 to inhibit the phagocytosis in human macrophages
Authors: Yi D.‐Y. , Xu Q.‐Y. , He Y. , Zheng X.‐Q. , Yang T.‐C. , Lin Y. 
Published: January 2024

AbstractBackgroundDuring Treponema pallidum (T. pallidum) infection, the host's immune system actively engages in pursuit and elimination of T. pallidum, while T. pallidum skillfully employs various mechanisms to evade immune recognition. Macrophages exhibit incomplete clearance of T. pallidum in vitro and the underlying mechanism of how T. pallidum resists the attack of macrophage remains unclear.ObjectivesTo investigate the effect of T. pallidum membrane protein Tp47 on the phagocytosis of macrophages.MethodsTHP‐1‐derived macrophages were used to investigate the role of Tp47 in the secretion of Prostaglandin E2 (PGE2) in macrophages and the mechanism by which Tp47 induced the production of PGE2, as well as the impact of PGE2 on the macrophage's phagocytosis.ResultsTp47 (1–10 μg/mL) significantly inhibited the phagocytosis of latex beads and T. pallidum in macrophages (p ≤ 0.05). PGE2 production by macrophages could be induced by Tp47, and the phagocytic function of macrophages could be restored using PGE2 antibody. Tp47 produced PGE2 by activating the PERK/NF‐κB/COX‐2 pathway in macrophages. Inhibitors targeting PERK, NF‐κB and COX‐2, respectively, reduced the level of PGE2 and restored the phagocytic function of macrophages.ConclusionTp47‐induced PGE2 production via the PERK/NF‐κB/COX‐2 pathway contributed to macrophage phagocytosis inhibition, which potentially contributes to immune evasion during the T. pallidum infection.
(−)‐myrtenol and (−)‐α‐pinene: Aggregation pheromone components of the cypress bark beetle Phloeosinus aubei
Authors: Bozsik Gábor , Molnár Béla Péter , Hegedüs Kristóf , Soós Tibor , Schulz Stefan , Tröger Armin , Francke Wittko , Szőcs Gábor 
Published: January 2024

AbstractThe cypress bark beetle, Phloeosinus aubei, is of increasing concern in the European market of scale‐leafed conifers. Neither the reproductive behaviour nor the chemical ecology have been studied in detail so far, and no specific attractant traps are available to monitor the flight of adults. We established that stridulation by males is crucial for acceptance by calling females. To unravel the chemical communication, hindgut extracts from unmated females were analysed by GC‐EAD, using male antennae. Gut extracts and Thuja occidentalis leaf extracts were analysed by GC/MS. Two antennally active compounds from gut extracts were identified as (−)‐myrtenol and (−)‐α‐pinene by enantioselective GC/MS. (−)‐Myrtenol was shown to be female‐specific, while (−)‐α‐pinene was found as a 2:1 mixture with the (+)‐enantiomer also among the volatiles of the host tree, T. occidentalis. To prove that the production of the above compounds in the beetles is related to reproduction, we treated females with JHIII. The gut extracts from these sexually mature females showed elevated levels of (−)‐α‐pinene compared to untreated control groups. Synthetic enantiomers of myrtenol and α‐pinene were tested separately by electroantennography, and all were found to be electrophysiologically active. The attractiveness of different mixtures of these compounds was compared using 4‐arm olfactometer tests: 4:1 mixtures of racemic α‐pinene with either (−)‐ or (+)‐myrtenol were significantly attractive to males and females, respectively. In field tests, multifunnel traps baited with a 5:1 mixture of (−)‐α‐pinene and (−)‐myrtenol caught significantly more males and females than unbaited control traps. We concluded that (−)‐α‐pinene and (−)‐myrtenol are components of a female‐produced aggregation pheromone. EAD activity and behaviour assays indicated that α‐pinene from Thuja is used by the beetles as part of a host plant kairomone. The complex communication system of P. aubei is discussed in a chemoecological context.