bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development
Authors: Fima Rebecca , Dussaud Sébastien , Benbida Cheïma , Blanchet Margault , Lanthiez François , Poupel Lucie , Brambilla Claudia , Moreau Martine , Boissonnas Alexandre , Gautier Emmanuel L. , Huby Thierry 
Published: September 2023

AbstractHypercholesterolemia is a major risk factor for atherosclerosis and associated cardiovascular diseases. The liver plays a key role in the regulation of plasma cholesterol levels and hosts a large population of tissue-resident macrophages known as Kupffer cells (KCs). KCs are located in the hepatic sinusoids where they ensure key functions including blood immune surveillance. However, how KCs homeostasis is affected by the build-up of cholesterol-rich lipoproteins that occurs in the circulation during hypercholesterolemia remains unknown. Here, we found that embryo-derived KCs (EmKCs) accumulated large amounts of lipoprotein-derived cholesterol, in part through the scavenger receptor CD36, and massively expanded early after the induction of hypercholesterolemia. After this rapid adaptive response, EmKCs exhibited mitochondrial oxidative stress and their numbers gradually diminished while monocyte-derived KCs (MoKCs) with reduced cholesterol-loading capacities seeded the KC pool. Decreased proportion of EmKCs in the KC pool enhanced liver cholesterol content and exacerbated hypercholesterolemia, leading to accelerated atherosclerotic plaque development. Together, our data reveal that KC homeostasis is perturbed during hypercholesterolemia, which in turn alters the control of plasma cholesterol levels and increases atherosclerosis.
Beauty beacon: correlated strategies for the Fisher runaway process
Authors: Ryabko Daniil , Vaca Angustias , Pazoca Prudencio 
Published: September 2023

AbstractSuppose that females choose males based on attributes that do not signal any genetic quality that is not related to the choice itself. Can being choosy confer selective advantage in this situation? We introduce correlated strategies, which means that females, when making their choice, may take into consideration external and independent random factors that are known to be observable by all. Individual-based simulation is used to show that, in this case, choosiness can emerge against the cost of over 25% when pitted against randomly mating females. Moreover, after being established in the population, it can sustain costs of over 35% . While such costs are not biologically plausible, they demonstrate unequivocally that sexual choice is a strong evolutionary force. Thus, correlated strategies are shown to be an evolutionary tool that channels randomness from the environment into genetic diversity. In addition, it turns out that a higher number of attributes in the ornament makes the choice more advantageous, which may result in a runaway complexity of sexual traits. Implications for the evolution of (female) cognitive abilities and speciation are discussed.
Unveiling the enigma of Brain-resident immune cells
Authors: Hwang Sunsook , Jang Juneil , Park Kyungsoo , Yim Yeong Shin 
Published: September 2023

AbstractThe immune system has been extensively studied in traditional immune hubs like the spleen and lymph nodes. However, recent advances in immunology highlight unique immune cell characteristics across anatomical compartments. In this study, we challenged conventional thinking by uncovering distinct immune cell populations within the brain parenchyma, separate from those in the blood, meninges, and choroid plexus, with unique transcriptional profiles. Brain-resident immune cells are not derived from maternal immune cells, and age-related changes, with an increase in CD8+T cells in aged mice, are noted. Alzheimer’s disease (AD) alters microglia’s interaction with brain-resident immune cells, emphasizing immune-brain dynamics. Furthermore, we reveal dynamic immune cell interactions and essential cytokine roles in brain homeostasis, with stable cytokine expression but emerging signaling pathways in AD. In summary, this study advances our understanding of brain-resident immune cells in both normal and pathological conditions.
Common food preservatives impose distinct selective pressures onSalmonellaTyphimurium planktonic and biofilm populations
Authors: Assaf Justin Abi , Holden Emma R. , Trampari Eleftheria , Webber Mark A. 
Published: September 2023

AbstractFood preservatives are crucial in controlling microbial growth in processed foods to maintain food safety. Bacterial biofilms pose a threat in the food chain by facilitating persistence on a range of surfaces and food products. Cells in a biofilm are often highly tolerant of antimicrobials and can evolve in response to antimicrobial exposure. Little is known about the efficacy of preservatives against biofilms and their potential impact on the evolution of antimicrobial resistance. In this study we investigated how the common food pathogenSalmonella entericaserovar Typhimurium responded to subinhibitory concentrations of four common food preservatives (sodium chloride, potassium chloride, sodium nitrite or sodium lactate) when grown planktonically and in biofilms. We found that each preservative exerted a unique selective pressure onS. Typhimurium populations grown planktonically and in a biofilm. Biofilm formation itself seemed to confer protection when exposed to each of the four preservatives, more so than previous exposure to sub-inhibitory concentrations of preservatives. There was a trade-off between biofilm formation and growth in the presence of three of the four preservatives, where prolonged preservative exposure resulted in reduced biofilm biomass and matrix production over time. Despite the differences in biofilm formation and preservative tolerance seen following three preservative stresses, they selected for mutations in global stress response regulatorsrpoSandcrp. There was no evidence for any selection of cross-resistance to antibiotics after preservative exposure, and some evidence that antagonism between preservatives can be exploited in compound cocktails to reduce contamination in the food chain.HighlightsPreservative-specific evolutionary adaptation ofSalmonellawas shown over time.A trade-off between adaptation and biofilm formation was observed.No cross-resistance to antibiotics was seen after preservative exposure.Mutations were found to be preservative-specific, with some common ones likerpoSandcrp.
Sharp habitat shifts, evolutionary tipping points and rescue: quantifying the perilous path of a specialist species toward a refugium in a changing environment
Authors: Dekens Léonard 
Published: September 2023

AbstractSpecialists species thriving under specific environmental conditions in narrow geographic ranges are widely recognised as heavily threatened by climate deregulation. Many might rely on both their potential to adapt and to disperse toward a refugium to avoid extinction. It is thus crucial to understand the influence of environmental conditions on the unfolding process of adaptation. Here, I study the eco-evolutionary dynamics of a sexually reproducing specialist species in a two-patch quantitative genetic model with moving optima. Thanks to a separation of ecological and evolutionary time scales and the phase-line study of the selection gradient, I derive the critical environmental speed for persistence, which reflects how the existence of a refugium impacts extinction patterns. Moreover, the analysis provides key insights about the dynamics that arise on the path to-wards this refugium. I show that after an initial increase of population size, there exists a critical environmental speed above which the species crosses a tipping point, resulting into an abrupt habitat switch. Besides, when selection for local adaptation is strong, this habitat switch passes through an evolutionary “death valley”, leading to a phenomenon related to evolutionary rescue, that can promote extinction for lower environmental speeds than the critical one.
Targeting high-density aromatic peptides to cardiolipin optimizes the mitochondrial membrane potential
Authors: Birk Alexander , Liu Shaoyi , Garcia-Marin Virginia , MacNeil Margaret A. 
Published: September 2023

ABSTRACTThe mitochondrial membrane potential (ΔΨm) is created by the accumulation of protons on an outer leaflet of the inner mitochondrial membrane and drives the synthesis of most cellular ATP, which is essential for cellular bioenergetics and survival. The ΔΨm also facilitates the electrogenic transport of cations, such as Ca2+, and regulates generation of reactive oxygen species, which serves as a powerful bioenergetic and stress-signaling regulator. Proton trapping on the outer leaflet of the inner mitochondrial membrane of mitochondrial cristae could be controlled by cardiolipin when the local pH is above 8. However, there is presently no technology that effectively targets strong bases to cardiolipin.We have developed a novel, high-density aromatic peptide (HDAP2) to preserve a proton gradient-driven potential in mitochondria by increasing proton trapping on cardiolipin (CL). HDAP2-induced formation of cardiolipin-HDAP2 complexes accumulated positive charges at the head of CL. The HDAP2-CL vesicles could accumulate the mitochondrial transmembrane potential probe, Tetramethylrhodamine (TMRM). This potential could be uncoupled with Carbonyl cyanide m-chlorophenylhydrazone (CCCP) and Dinitrophenol (DNP), indicating that an interaction of HDAP2 with CL could support a proton gradient-driven transmembrane potential.We demonstrated that this novel, water-soluble peptide is cell-permeable, targets mitochondria without causing cell toxicity, and promotes cell survival during serum starvation. Importantly, the HDAP2-cardiolipin complex-mediated optimization of the proton gradient was supported by the ability of HDAP2 to prevent CCCP-mediated mitochondrial depolarization in ARPE-19 cells in a dose-dependent manner. Based on its mechanism of action, HDAP2 could promote cellular homeostasis, which would have broad clinical applicability for the prevention, recovery and reversal of many acute and chronic disease conditions, such as neurodegeneration, ischemia– reperfusion injury, and inflammation.
The role of green strategic alliances and their impact on green organizational identity and sustainability
Authors: Lopes Cancela Beatriz , Coelho Arnaldo , Neves Maria Elisabete 
Published: September 2023

PurposeThis study aims to investigate the role of green strategic alliances (GSAs) in fostering a green shared vision (GSVis) and green shared value (GSV) and their impact on green organizational identity (GOI) and sustainability.Design/methodology/approachThe authors employed structural equation modeling to analyze data collected through a 60-item questionnaire administered in Portugal and China, allowing the authors to test their theoretical model.FindingsThe findings of the authors' study indicate that green strategic alliances have a positive influence on the development of a GSVis and GSV in both countries. This, in turn, contributes to improved sustainability and the establishment of a GOI. Furthermore, the authors' results demonstrate that these alliances enhance GSV, resulting in enhanced sustainability performance and a stronger green identity, with a notable increase in awareness of environmental and social practices.Originality/valueThis article is innovative as it applies organizational learning and value creation theories to gain a deeper understanding of how alliances can shape the green identity of companies and contribute to their overall sustainability.
The influence of family firm succession on financialisaton: evidence from China
Authors: Zhang Lijie , Baranchenko Yevhen , Lin Zhibin , Ren Li 
Published: September 2023

PurposeThis study seeks to fill a gap in the literature by examining the role of family firm succession in shaping the firm's approach to financialisation, which has received limited attention in the previous research. In addition, the study explores the influence of factors such as clan culture, concentration of control and generational differences on the relationship between succession and financialisation.Design/methodology/approachData were based on a sample of 7,023 firm-year observations, compiled from the listed family firms in China's A-share. Several tobit models are used for analysing the data and testing the hypotheses.FindingsFamily firm succession is negatively related to the level of financialisation, and this relationship is influenced by clan culture, concentration of control and the stage of succession. Specifically, a higher clan culture, a greater concentration of ultimate control by the controlling family member and the dominance of the first generation in management strengthens the negative relationship between family firm succession and financialisation.Originality/valueThis study offers new insights into the consequence of family firm succession on a new area of the firm's strategy, i.e. financialisation. The study further advances the understanding of family firm succession by considering the role of clan culture, the concentration of control and the stage of the succession process.
Time series observation of relationship between United States private residential construction spending and its indicators
Authors: Zhang Xingrui , Yang Eunhwa , Wang Yunpeng 
Published: September 2023

Purpose
Private residential construction spending (PRRESCON) is an important indicator for assessing housing supply/demand and economic strength. Currently, there are no comprehensive studies on PRRESCON forecasting. This study aims to address the gap in knowledge by conducting a comprehensive exploration of indicators for PRRESCON using time series methods.

Design/methodology/approach
Granger causality test trials were conducted between PRRESCON and all of its potential indicators before the vector autoregression model was implemented. Extensive effort was exerted toward model interpretation in the form of impulse–response functions.

Findings
Impulse–response functions indicated that the escalation of labor supply, material/construction costs and issued building permits at any given time consistently had a positive impact on PRRESCON 10–11 months later, with a 95% confidence interval. Conversely, the unemployment rate and housing value escalations at any given time were found to have a negative impact on PRRESCON 10–11 months later in more than 95% of the instances. Furthermore, material/construction cost escalations at any given time were shown to have a negative impact on PRRESCON 7 months later in more than 95% of the instances.

Originality/value
Current forecasting literature on construction spending focuses exclusively on the parameter’s relationship with gross domestic product and the architectural billing index. This study reveals many additional indicators, many of which are directly related to the implementation of housing development projects. The paper is also the first in the body of forecasting literature, to the best of the authors’ knowledge, to conduct impulse–response analysis on residential construction spending.
Life as a relational unit, the process of ecopoiesis
Authors: Lavanderos Leonardo , Malpartida Alejandro 
Published: September 2023

PurposeThe purpose of this study is to introduce the concept of Ecopoiesis. Introduction of the concept of ecopiesis, which explains the linkage strategy between relational and energetic resources (sustainability) that enable the relational viability of living things.Design/methodology/approachThe design is based on the use of the relationship between abduction, epigenesis, cismogenesis and morphogenesis.FindingsThis paper concludes with a counter-intuitive proposal to the dominant lines of thought, distinguishing: Complexity as vital interweaving, Aristotelian Oikos as communitarian distinction, Organism-Entorno from relational theory (beyond the interactional), in a cybernetic referential framework that allows tending to sustain and sustain life from Ecopoiesis.Originality/valueAccording to a relational theory of cognition, the sources of knowledge go beyond genetic and environmental factors. In the sphere of explanation, this study moves from “how much,” “why” and “how” to “why not.” Thus, the processes involved in understanding the living are forced to move from the logic of parts to the logic of patterns, which implies developing an explanation that considers the unique characteristics of development, encompassing the diverse origins of the organization of the living.
The confessional community
Authors: Garcia Angela 
Published: September 2023

AbstractIn the past two decades, drug‐treatment centers called anexos (annexes) have proliferated throughout Mexico. Run and attended by the working poor, anexos’ therapeutic practices blend criminal violence and religious ritual, and they are widely condemned as abusive and unethical. Based on several years of ethnographic research in Mexico City, this article situates anexos within a larger historical frame and examines how they conjure and rework contemporary forms of affliction through a novel form of confessional practice. It shows how confession simultaneously reproduces pervasive images of violence while also disclosing projects of communitarian survival that are ethically affirmative. In doing so, this article demonstrates that anexos’ confessional practices constitute an aesthetics and politics of recovery that calls for a rethinking of criminal, religious, and therapeutic domains.
The impact of age‐relevant and generic infographics on knowledge, attitudes and intention to attend cervical screening: A randomized controlled trial
Authors: Waite Frances , Marlow Laura A. V. , Nemec Martin , Waller Jo 
Published: September 2023

AbstractObjectivesCervical screening uptake in England is falling. Infographics could strengthen intention to attend, increase positive attitudes and improve knowledge. Age targeting could improve these outcomes further. We tested the impact of generic and age‐targeted infographics.DesignA randomized controlled trial using an age‐stratified, parallel‐group design.MethodsWomen aged 25–64 (n = 2095) were recruited through an online panel and randomized to see one of the three infographics. We tested: (i) impact of a generic cervical screening infographic compared to a control infographic on an unrelated topic with all screening age women and (ii) impact of an age‐targeted infographic compared to a generic cervical screening infographic with older women (50–64 years). Intentions, knowledge and attitudes were measured.ResultsWomen aged 25–64 years who viewed the generic infographic had significantly higher intentions [F(1, 1513) = 6.14, p = .013,  = .004], more accurate beliefs about the timeline of cervical cancer development (OR: 5.18, 95% CI: 3.86–6.95), more accurate social norms (OR: 3.03, 95% CI: 2.38–3.87) and more positive beliefs about screening benefits (OR: 2.23, 95% CI: 1.52–3.28) than those viewing the control infographic. In the older age group, there was no significant difference in intention between those viewing the generic versus age‐targeted versions [F(1, 607) = .03, p = .853,  < .001], but the age‐targeted version was more engaging [F(1, 608) = 9.41, p = .002,  = .015].ConclusionsA cervical screening infographic can result in more positive attitudes and better knowledge and may have a small impact on intentions. Although age targeting did not affect intention, it had a positive impact on engagement and may therefore be useful in encouraging women to read and process materials.
Class matters—Children's perceptions of sports coaching
Authors: Goosen Tanya , Twitchen Alex 
Published: September 2023

AbstractThe aim of the study was to acquire an insight into the experiences of 84 children from two schools in the United Kingdom who were asked to describe their interpretation of ‘excellent sports coaching’. Using visual and narrative research methods it was found that the influence of social class was significant. Children from higher socioeconomic groups described excellent sports coaching as a structured and adult‐led process, whereas children from lower socioeconomic classes described it as being more play‐like and self‐determined. Reasons for this difference are explained through the contrasting attitudes to sport and physical activity present amongst different social classes.
Programmed cell death ligand 1 expression associated with subtypes of post‐transplant lymphoproliferative disorder among pediatric kidney transplant recipients
Authors: Weinberg Olga K. , Pinkus Geraldine C. , Ramos‐Gonzalez Gabriel J. , Agur Timna , Rodig Nancy M. 
Published: September 2023

AbstractBackgroundProgrammed cell death ligand 1 (PD‐L1) expression on tumor cells engages the PD‐1 receptor on T cells, inhibiting anti‐tumor responses. PD‐L1 has been detected in cases of post‐transplant lymphoproliferative disorder (PTLD) but reports are limited. Here we examine PD‐L1 expression and evaluate for clinical correlations.MethodsTwenty‐one cases of PTLD were identified among pediatric kidney transplant recipients at our institution from February 1996 to April 2017. Using paraffin‐embedded tissue biopsies, we examined 21 primary tumors for expression using PD‐L1 monoclonal antibody performed with PAX5 as a double stain. We scored expression of PD‐L1 on lesional B‐cells as a percentage of positive cells. Clinical course and outcome were obtained from retrospective chart review.ResultsApplying revised 2017 WHO PTLD classification showed five non‐destructive, nine polymorphic, and seven monomorphic cases. Average PD‐L1 expression based upon PTLD subtype was: non‐destructive 11%, polymorphic 43%, and monomorphic 73% (p = .01). Two patients transferred shortly after diagnosis, five received chemotherapy, and three died from PTLD. Among the fatalities, all showed monomorphic PTLD and 90% of lesional B‐cells expressed PD‐L1.ConclusionIn this case series, significant differences in PD‐L1 expression were seen among different subtypes, and monomorphic PTLD demonstrated the highest expression. Study of a larger cohort is needed, and if the correlation of PD‐L1 expression and PTLD subtype is confirmed, this may highlight the potential utility of checkpoint inhibitor therapy in cases of severe or refractory disease among kidney transplant recipient in whom the risk of allograft loss is acceptable given the option of chronic dialysis.