bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-separation parenting apps in the hands of family law practitioners: expectations versus experience
Authors: Irving Michelle A , Heard Genevieve , Smyth Bruce M , Payne Jason L , Althor Glenn 
Published: December 2023

Abstract
Post-separation parenting apps are an alternative to mainstream digital communication (e.g. text and email) for separated parents. They vary in cost and features, generally incorporating a messaging tool, shared calendar, expense tracker, and the ability to export records for legal purposes. While often recommended in the context of family law, evidence for efficacy and safety is lacking. This study sought insights from family law professionals about the value of post-separation parenting apps in high-conflict cases. Thirty family mediators, known in Australia as Family Dispute Resolution Practitioners, role-played pairs of high-conflict separated parents using one of 10 popular post-separation parenting apps. After completing a set of common co-parenting tasks, dyadic interviews and focus groups were used to discuss their observations. Overall, practitioners expressed disappointment with the apps. Key themes included potential individual differences in separated parents’ technical skills, time availability, and intentions towards app use. Usability challenges specific to the tested apps were also identified. Rather than simplifying interactions for separated parents, these combined contextual variables were thought likely to contribute to frustration and inter-parental conflict. As a result, practitioners in the study resolved to be far more cautious with app recommendations for high-conflict clients.
The Impact of Recent Demography on Functional Genetic Variation in North African Human Groups
Authors: Lucas-Sánchez Marcel , Abdeli Amine , Bekada Asmahan , Calafell Francesc , Benhassine Traki , Comas David 
Published: December 2023

Abstract
The strategic location of North Africa has made the region the core of a wide range of human demographic events, including migrations, bottlenecks, and admixture processes. This has led to a complex and heterogeneous genetic and cultural landscape, which remains poorly studied compared to other world regions. Whole-exome sequencing is particularly relevant to determine the effects of these demographic events on current-day North Africans’ genomes, since it allows to focus on those parts of the genome that are more likely to have direct biomedical consequences. Whole-exome sequencing can also be used to assess the effect of recent demography in functional genetic variation and the efficacy of natural selection, a long-lasting debate. In the present work, we use newly generated whole-exome sequencing and genome-wide array genotypes to investigate the effect of demography in functional variation in 7 North African populations, considering both cultural and demographic differences and with a special focus on Amazigh (plur. Imazighen) groups. We detect genetic differences among populations related to their degree of isolation and the presence of bottlenecks in their recent history. We find differences in the functional part of the genome that suggest a relaxation of purifying selection in the more isolated groups, allowing for an increase of putatively damaging variation. Our results also show a shift in mutational load coinciding with major demographic events in the region and reveal differences within and between cultural and geographic groups.
Integration of solar receiver and thermal energy storage into a single unit in concentrating solar plants
Authors: Yang Song , Wang Jun , Lund Peter D 
Published: December 2023

Abstract
Integrating solar receivers and thermal energy storage in a concentrating solar thermal plant helps to enhance plant efficiency and cost-effectiveness. Here, we provide an overview of the technology to unify solar receivers and thermal energy storage into a single system. We discuss the advantages, challenges, and prospects associated with this innovative approach. This emerging technology has the potential to improve overall thermal performance and facilitate operation of high-temperature dispatchable concentrating solar thermal systems.
Detailing Early Shoot Growth Arrest in Kro-0 x BG-5 Hybrids of Arabidopsis thaliana
Authors: Sageman-Furnas Katelyn , Duarte Gustavo T , Laitinen Roosa A E 
Published: December 2023

Abstract
Shoot growth directly impacts plant productivity. Plants adjust their shoot growth in response to varying environments to maximize resource capture and stress resilience. While several factors controlling shoot growth are known, the complexity of the regulation and the input of the environment are not fully understood. We have investigated shoot growth repression induced by low ambient temperatures in hybrids of Arabidopsis thaliana Kro-0 and BG-5 accessions. To continue our previous studies, we confirmed that the Kro-0 allele of DYNAMIN-RELATED PROTEIN 3B causes stunted shoot growth in the BG-5 background. We also found that shoot growth repression was most pronounced near the apex at a lower temperature and that the cells in the hybrid stem failed to elongate correctly. Furthermore, we observed that shoot growth repression in hybrids depended on light availability. Global gene expression analysis indicated the involvement of hormones, especially strigolactone, associated with the dwarf phenotype. Altogether, this study enhances our knowledge on the genetic, physiological and environmental factors associated with shoot growth regulation.
Particulate matter composition drives differential molecular and morphological responses in lung epithelial cells
Authors: Engels Sean M , Kamat Pratik , Pafilis G Stavros , Li Yukang , Agrawal Anshika , Haller Daniel J , Phillip Jude M , Contreras Lydia M 
Published: December 2023

Abstract
Particulate matter (PM) is a ubiquitous component of air pollution that is epidemiologically linked to human pulmonary diseases. PM chemical composition varies widely, and the development of high-throughput experimental techniques enables direct profiling of cellular effects using compositionally unique PM mixtures. Here, we show that in a human bronchial epithelial cell model, exposure to three chemically distinct PM mixtures drive unique cell viability patterns, transcriptional remodeling, and the emergence of distinct morphological subtypes. Specifically, PM mixtures modulate cell viability, DNA damage responses, and induce the remodeling of gene expression associated with cell morphology, extracellular matrix organization, and cellular motility. Profiling cellular responses showed that cell morphologies change in a PM composition-dependent manner. Finally, we observed that PM mixtures with higher cadmium content induced increased DNA damage and drove redistribution among morphological subtypes. Our results demonstrate that quantitative measurement of individual cellular morphologies provides a robust, high-throughput approach to gauge the effects of environmental stressors on biological systems and score cellular susceptibilities to pollution.
Just Kidding? Two Roles for the Concept of Joking in Political Speech
Authors: Walker Zoe 
Published: December 2023

Abstract
In this paper, I discuss two roles for the concept of joking in political speech. First, I discuss how claiming to have been joking can provide speakers with a powerful form of deniability. I argue that the aesthetic dimension of jokes makes such a denial especially well placed to undermine both a hearer's evidence for an utterance having been sincere, and, separately, their belief that it was sincere—I call the latter ‘aesthetic gaslighting’. Second, I discuss the use of jokes to influence hearers’ thinking and behaviour under the radar. I show that not only does the fact that an utterance was a joke fail to prevent it from influencing hearers, but in some cases, the fact that it was a joke actually makes it more influential than a sincere utterance would have been.
TNFAIP3 Derived from Skeletal Stem Cells Alleviated Rat Osteoarthritis by Inhibiting the Necroptosis of Subchondral Osteoblasts
Authors: Li Xiao-Tong , Li Zhi-Ling , Li Pei-Lin , Wang Fei-Yan , Zhang Xiao-Yu , Wang Yu-Xing , Zhao Zhi-Dong , Yin Bo-Feng , Hao Rui-Cong , Mao Ning , Xia Wen-Rong , Ding Li , Zhu Heng 
Published: December 2023

Abstract
Recent investigations have shown that the necroptosis of tissue cells in joints is important in the development of osteoarthritis (OA). This study aimed to investigate the potential effects of exogenous skeletal stem cells (SSCs) on the necroptosis of subchondral osteoblasts in OA. Human SSCs and subchondral osteoblasts isolated from human tibia plateaus were used for Western blotting, real-time PCR, RNA sequencing, gene editing, and necroptosis detection assays. In addition, the rat anterior cruciate ligament transection OA model was used to evaluate the effects of SSCs on osteoblast necroptosis in vivo. The micro-CT and pathological data showed that intra-articular injections of SSCs significantly improved the microarchitecture of subchondral trabecular bones in OA rats. Additionally, SSCs inhibited the necroptosis of subchondral osteoblasts in OA rats and necroptotic cell models. The results of bulk RNA sequencing of SSCs stimulated or not by tumor necrosis factor α suggested a correlation of SSCs-derived tumor necrosis factor α-induced protein 3 (TNFAIP3) and cell necroptosis. Furthermore, TNFAIP3-derived from SSCs contributed to the inhibition of the subchondral osteoblast necroptosis in vivo and in vitro. Moreover, the intra-articular injections of TNFAIP3-overexpressing SSCs further improved the subchondral trabecular bone remodeling of OA rats. Thus, we report that TNFAIP3 from SSCs contributed to the suppression of the subchondral osteoblast necroptosis, which suggests that necroptotic subchondral osteoblasts in joints may be possible targets to treat OA by stem cell therapy.
Dense Lichenoid Inflammation in Paget Disease: A Diagnostic Pitfall
Authors: Zayas Jacqueline , Sokumbi Olayemi 
Published: December 2023

Abstract:
Mammary Paget disease is a rare form of breast cancer, which typically presents as an eczematous plaque on the nipple or surrounding skin. It is often a clinical diagnosis that is confirmed with skin biopsy. Histologic hallmarks of mammary Paget disease include large, pleomorphic, malignant, ductal epithelial cells within the epidermis. Chronic lichenoid inflammation may be seen in the papillary dermis but is not diagnostic. Because mammary Paget disease often overlies ductal carcinoma in situ or invasive carcinoma of the breast, prompt bilateral mammography is warranted. We report a case of Paget disease of the nipple with negative breast imaging that was originally misdiagnosed due to a dense lichenoid infiltrate obscuring the neoplasm.
Cutaneous Horn Presentation in Porokeratotic Eccrine Ostial and Dermal Duct Nevus. A Brief Review and Case Report
Authors: Cuartero-Castro Gerardo , Cid-García Anahí , Téllez-Alvarado Adriana , Gutiérrez-Quiroz Claudia Teresita 
Published: December 2023

Abstract:
Porokeratotic eccrine ostial and dermal duct nevus is a rare adnexal hamartoma characterized by the presence of a cornoid lamella exclusively overlying eccrine acrosyringia. Different clinical presentations have been reported in the literature. Here, we report a case of a 6-year-old girl diagnosed with porokeratotic eccrine ostial and dermal duct nevus confirmed by histopathologic study. Atypical lesions are described as whitish, warty-looking neoformations located in the anterolateral region of the right hip (cutaneous horn).
The Role of Rosmarinic Acid in the Protection Against Inflammatory Factors in Rats Model With Monocrotaline-Induced Pulmonary Hypertension: Investigating the Signaling Pathway of NFκB, OPG, Runx2, and P-Selectin in Heart
Authors: Atefipour Narges , Dianat Mahin , Badavi Mohammad , Radan Maryam , Mard Seyyed Ali 
Published: December 2023

Abstract:
Shortness of breath and syncope are common symptoms of right ventricular failure caused by pulmonary arterial hypertension (PAH), which is the result of blockage and increased pressure in the pulmonary arteries. There is a significant amount of evidence supporting the idea that inflammation and vascular calcification (VC) are important factors in PAH pathogenesis. Therefore, we aimed to investigate the features of the inflammatory process and gene expression involved in VC in monocrotaline (MCT)-induced PAH rats. MCT (60 mg/kg, i.p.) was used to induce PAH. Animals were given normal saline or rosmarinic acid (RA) (10, 15, and 30 mg/kg, gavage) for 21 days. An increase in right ventricular systolic pressure was evaluated as confirming PAH. To determine the level of inflammation in lung tissue, pulmonary edema and the total and differential white blood cell counts in the bronchoalveolar lavage fluid were measured. Also, the expression of NFκB, OPG, Runx2, and P-selectin genes was investigated to evaluate the level of VC in the heart. Our experiment showed that RA significantly decreased right ventricular hypertrophy, inflammatory factors, NFκB, Runx2, and P-selectin gene expression, pulmonary edema, total and differential white blood cell count, and increased OPG gene expression. Therefore, our research showed that RA protects against MCT-induced PAH by reducing inflammation and VC in rats.
Resurfacing Dehiscence(s) Without Reducing Diverticulum Effectively Silences Pulsatile Tinnitus: Novel Surgical Techniques for Diverticulum and Intraoperative Microphone Monitoring
Authors: Hsieh Yue-Lin , Gao Xiuli , Chen Xi , Wang Shenjiang , Wang Wuqing 
Published: December 2023

Objective
To emphasize the surgical importance of addressing dehiscence over diverticulum in resolving pulsatile tinnitus (PT) in patients with sigmoid sinus wall anomalies (SSWAs) and investigate anatomical differences.

Study Design
Retrospective data analysis.

Setting
Multi-institutional tertiary university medical centers.

Patients
Fifty participants (dehiscence/diverticulum, 29:21 cases) with SSWA-associated PT were included in the study. All 21 diverticulum participants underwent surgical intervention.

Interventions
1) Surgical intervention with novel techniques monitored by intraoperative microphone. 2) Radiologic and ophthalmologic imaging methods.

Main Outcome Measure(s)
Quantitative and qualitative preoperative and postoperative alterations of PT and anatomical differences between dehiscence and diverticulum.

Results
Addressing dehiscence overlying diverticulum and sigmoid sinus wall dehiscences significantly reduced visual analog score and Tinnitus Handicap Inventory (p < 0.01). Sinus wall reconstruction led to substantial PT sound intensity reduction in the frequency range of 20 to 1000 Hz and 20 to 500 Hz (paired-sample t test, p < 0.01). Diploic vein analysis showed a significant positive correlation in 85.7% of the diverticulum cohort compared with the dehiscence cohort (p < 0.01). Eight percent of the participants exhibited papilledema, which was limited to the dehiscence cohort.

Conclusion
1) Effective reduction of PT can be achieved by addressing all dehiscences, including those overlying the diverticulum, without the need to exclude the diverticulum. 2) Diploic vein may involve in the formation of diverticulum, and loss of dura mater and vascular wall thickness are observed at the SSWA locations.
Pre-Registration Nursing Students' Perceptions of Digital Health Technology on the Future of Nursing
Authors: Wong Pauline , Brand Gabrielle , Dix Samantha , Choo Dawn , Foley Pieternella , Lokmic-Tomkins Zerina 
Published: December 2023

Background:
Health informatics competencies, digital health education, and nursing students' perceptions of technology are critical to ensure a future digitally capable health care workforce.

Purpose:
To explore preregistration students' perceptions of digital health technology impact on their role as nurses.

Methods:
Using a qualitative exploratory approach, students from 2 Australian universities were purposively sampled. Data were collected through photo-elicitation from 3 focus groups and thematically analyzed. Photo-elicitation provided reference points to encourage more in-depth exploration.

Results:
Themes included fear of the unknown and who am I? Nursing in a digital world. Human interaction was fundamental to their nursing role and digital health technology could depersonalize care, creating tension around their reason for choosing a nursing career.

Conclusions:
Educators should prepare students to redefine their nursing identity by exploring how digital health technology augments their practice and critical thinking skills, while addressing fear of a perceived threat to the future of nursing.
Knowledge Acquisition Based on Participant Role Assignment in a High-Fidelity Simulation
Authors: Hooper Barbara L. , Carlson Nancy G. 
Published: December 2023

Background:
Participant roles can vary with simulation. Some roles involve providing direct care during the simulation, whereas other roles involve observing the simulation either in the simulation environment or in another room with audiovisual capabilities.

Purpose:
To determine whether learning outcomes are comparable for students regardless of role played in a simulation.

Methods:
A quasi-experimental design was used to determine whether knowledge acquisition was influenced by role assignment (primary or secondary nurse, family member, or observer) when participating in a high-fidelity simulation among 267 study participants.

Results:
There was a statistically significant increase in the mean score for knowledge acquisition for all participants (P < .001). There was no difference in knowledge acquisition based on the role assignment in the simulation (F = 0.28, P = .84).

Conclusions:
Knowledge acquisition is possible regardless of the role played in a high-fidelity simulation.
Structural Bias in the Completeness of Death Investigations for Sudden Unexpected Infant Deaths (SUIDs)
Authors: Thyden Naomi Harada , Slaughter-Acey Jaime , Widome Rachel , Warren John Robert , Osypuk Theresa L. 
Published: December 2023

Objective:
To assess sudden unexpected infant death (SUID) investigations for structural inequities by race/ethnicity and geography.

Methods:
The SUID Case Registry compiles data on death investigations. We analyzed cases from 2015 to 2018 (N = 3847) to examine likelihood of an incomplete death investigation, defined as missing autopsy, missing scene investigation, or missing detailed information about where and how the body was found. We also analyzed which specific components of death investigations led to the greatest number of incomplete investigations.

Results:
Twenty-four percent of SUIDs had incomplete death investigations. Death scenes in rural places had 1.51 times the odds of incomplete death investigations (95% confidence interval [CI], 1.19-1.92) compared with urban areas. Scene investigations led by law enforcement were more likely to result in incomplete death investigations (odds ratio [OR] = 1.49; 95% CI, 1.18-1.88) than those led by medical examiners. American Indian/Alaska Native SUIDs were more likely than other racial groups to have an incomplete investigation (OR = 1.49; 95% CI, 0.92-2.42), more likely to occur in rural places (P = .055), and more likely to be investigated by law enforcement (P < .001). If doll reenactments had been performed, 358 additional cases would have had complete investigations, and if SUID investigation forms had been performed, 243 additional cases would have had complete investigations. American Indian/Alaska Native SUIDs were also more likely to be missing specific components of death investigations.

Conclusion:
To produce equitable public health surveillance data used in prevention efforts, it is crucial to improve SUID investigations, especially in rural areas and among American Indian/Alaska Native babies.
Evaluating Mediastinal Lymph Node Metastasis of Non–Small Cell Lung Cancer Using Mono-exponential, Bi-exponential, and Stretched-exponential Models of Diffusion-weighted Imaging
Authors: Zheng Yu , Han Na , Huang Wenjing , Jiang Yanli , Zhang Jing 
Published: December 2023

Purpose:
To explore and compare the diagnostic values of mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted imaging (DWI) parameters of primary lesions and lymph nodes (LNs) to predict mediastinal LN metastasis in patients with non–small cell lung cancer.

Patients and Methods:
Sixty-one patients with non–small cell lung cancer underwent preoperative magnetic resonance imaging, including multiple b-value DWI. The DWI parameters, including apparent diffusion coefficient (ADC) from a mono-exponential model, true diffusion (D) coefficient, pseudo-diffusion (D*) coefficient, and perfusion fraction (f) from a bi-exponential model, distributed diffusion coefficient (DDC) and intravoxel diffusion heterogeneity index (α) from a stretched-exponential model of primary tumors and LNs and the size characteristics of LNs, were measured and compared. Multivariate logistic regression analysis was used to establish models for predicting mediastinal LN metastasis. Receiver operating characteristic analysis was applied to evaluate diagnostic performances.

Results:
The DWI parameters of primary tumors showed no statistical significance between LN metastasis-positive and LN metastasis-negative groups. Nonmetastatic LNs had significantly higher ADC, D, DDC, and α values compared with metastatic LNs (all P < 0.05). The short-dimension, long-dimension, and short-long dimension ratio of metastatic LNs was significantly larger than those of nonmetastatic ones (all P < 0.05). The D value showed the best diagnostic performance among all DWI-derived single parameters, and the short dimension of LNs performed the same among all the size variables. Furthermore, the combination of DWI parameters (ADC and D) and the short dimension of LNs can significantly improve diagnostic efficiency.

Conclusions:
The ADC, D, DDC, and α from the mono-exponential, bi-exponential, and stretched-exponential models were demonstrated efficient in differentiating benign from metastatic LNs, and the combination of ADC, D, and short dimension of LNs may have a better diagnostic performance than DWI or size-derived parameters either in combination or individually.