bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Spirituality in Pain Experiences among Adults with Cancer: An Explanatory Sequential Mixed Methods Study
Authors: Miller Megan , Speicher Stephanie , Hardie Katie , Brown Roger , Rosa William E. 
Published: October 2023

Abstract

Purpose
Foundational research demonstrates that spirituality may affect the way people with cancer experience pain. One potential route is through alterations in thoughts and beliefs, such as pain-related catastrophizing. The purpose of this study is to understand whether spirituality impacts pain experiences through pain-related catastrophizing.
Methods
This explanatory sequential mixed methods study was informed by an adapted Theory of Unpleasant Symptoms. Data were collected via online surveys (N = 79) and follow-up qualitative interviews (N = 25). Phase 1 employed Empirical Bayesian analysis. Phase 2 used deductive content analysis. Phase 3 involved creating a mixed methods joint display to integrate findings and draw meta inferences.
Results
Results indicate that spirituality was directly negatively associated with pain-related catastrophizing, and indirectly negatively associated with the outcomes of pain interference, pain severity, and pain-related distress. Qualitative categories highlight the supportive role of spirituality when facing pain, while also shedding light on the limitations of spirituality in the context of some pain (i.e., severe, neuropathic, and/or chronic). Mixed methods findings reveal the importance of spirituality for some people as they face cancer and cancer-related pain, as well as the need for integrating spirituality as part of a larger pain management plan.
Conclusions
This research advances supportive cancer care by exploring the complex role of spirituality in pain experiences. Findings will inform further exploration into the role of spirituality in supporting holistic symptom management in the context of cancer, as well as developing and testing interventions to enhance spirituality and address symptom-related suffering.
The relationship between depression and mobile phone addiction in university students: the mediating role of anxiety and self-esteem
Authors: Dou Xiaofeng , Lu Jiachen , Yu Yingying , Yi Yaohui , Zhou Ling 
Published: October 2023

Abstract

Purpose
Cell phone addiction has become a widespread social phenomenon in China. Because this phenomenon has caused a wide range of social concerns, this study aims to explore the relationships among depression, anxiety, self-esteem, and cell phone addiction. It further aims to conduct an analysis of the factors affecting cell phone addiction.
Method
This study was conducted in 2023. We used the SDS depression scale, the SAS anxiety scale, the SAS cell phone addiction scale and the Robert self-esteem scale. Pearson correlation and structural equation modeling were used to explore the relationships among depression, anxiety, self-esteem, and cell phone addiction.
Results
The study's findings suggest that there is a correlation between depression, anxiety, self-esteem, and cell phone addiction. Additionally, self-esteem mediates the relationship between anxiety and cell phone addiction. Lastly, in the development of cell phone addiction, anxiety and self-esteem have sequential mediating roles.
Conclusion
These findings offer insight into the underlying mechanisms of the relationship between depression and cell phone addiction, thereby helping researchers and educators. In addition, the results provide practical and effective suggestions for the prevention and intervention of cell phone addiction among college students.
Comprehensive stereo monitoring and traceability analysis of ozone pollution: A case study of a continuous pollution process in Ganzhou City
Authors: Ma Fei , Wang Ming , Ye Conglei , Deng Xu , Zhang Shuai 
Published: October 2023

Abstract

The processes of O3 source and sink are complicated, and few existing studies focus on Ganzhou City, leading to a limited understanding of O3 pollution in Ganzhou City or even Jiangxi Province. Here, we investigate the comprehensive formation mechanism of O3 pollution from the aspects of precursor emission, chemical transformation, meteorological effects and three-dimensional transmission by using the vertical profiles for O3 concentration and wind information, ground monitoring data of ambient air quality, meteorological and volatile organic compounds (VOCs). The mean concentrations of O3, NO2 and TVOC shows significant growth in the early stage of O3 pollution, while the VOCs components is basically the same and the concentration proportion of the average VOCs concentration in TVOC and the proportion of the average O3 formation potential (OFP) concentration in the total OFP concentration did not change significantly before and after O3 pollution. The frequent high-altitude subsidence of O3 air mass, the night-time residue and the superposition of large-area transmission result in the characteristics of multi-peak and flat-headed peaks on the daily variation curve of O3, which is not conducive to the calculation of O3-8H concentration and are important reasons for O3 exceeding the standard. Meanwhile, the meteorological conditions like wind velocity and temperature may also influence the variations in the O3 concentration. From the point of view of air pollution prevention, the industrial enterprises and mobile sources may still be the vital industry of VOCs supervision and propional, 1-pentene, m-/p-xylene and isoprene could be considered as the important species under emergency management on O3 polluted days due to their significant increasing in OFP concentrations.
Might low-level laser therapy interfere with the frequency of severe mucositis and oral candidiasis? A retrospective analysis in patients with head and neck carcinoma
Authors: Nascimento Rebeca Barros , Neri Bruna Portle , Moutinho Mylena Melo , Fortuna Tila , Martins Gabriela Botelho , Carrera Manoela , Lima Hayana Ramos 
Published: October 2023

Abstract
Purpose
Considering the tumor in the oral cavity or the oropharynx and nasopharynx region might be an aggravating factor for Oral Mucositis (OM) manifestation, the present study aimed to evaluate whether the location of the tumor and the use of Low-level laser therapy (LLLT) might affect the frequency of oral candidiasis during radiotherapy (RT) and/or chemotherapy (CT) treatments.
Methods
Seventy-four patients with head and neck cancer were evaluated from 2016 to 2019. All these patients were submitted to RT in an accumulated dose of 48 to 70 Gy of radiation. These patients were followed with OM and OC treatment and divided into two groups: No-LLLT (SHAM group) and LLLT (Laser group). The correlation between clinical characteristics such as age, tumor size (T), metastatic lymph node (N), number of RT and CT sessions, candidiasis, and OM were analyzed.
Results
Mucositis grades 1 and 2 were the most common among all patients, especially before the 12th radiotherapy session, regardless of the treatment with LLLT. Additionally, no difference in the grade of OM and OC was significantly observed when comparing the two laser therapy groups. OC was more frequent after the 12th radiotherapy session in all groups.
Conclusion
OM and OC was not changed by LLLT, although it helped to reduce the incidence of severe cases of OM. Patients with oral cavity tumor presented more OM, especially high grades, then patients with tumors in other regions of the head and neck, which seems to be related to the irradiation parameters of radiotherapy and/or with the limitation of conduction of LLLT in tumor areas.
Neutrophil extracellular trap formation and deoxyribonuclease I activity in patients with otitis media with antineutrophil cytoplasmic antibody-associated vasculitis
Authors: Morita Shinya , Nakamaru Yuji , Fukuda Atsushi , Fujiwara Keishi , Suzuki Masanobu , Hoshino Kimiko , Honma Aya , Nakazono Akira , Homma Akihiro 
Published: October 2023

Abstract

No previous studies focused on the degradation of neutrophil extracellular traps (NETs) or deoxyribonuclease (DNase) I activity in the pathogenesis of otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV). The aim of this study was to explore the formation and degradation of NETs in the middle ear of patients with OMAAV during the onset and remission phases of the disease, with a particular focus on the relationships between the quantifiable NETs levels and DNase I activity. OMAAV patients were eligible for inclusion. Patients with otitis media with effusion (OME) were examined as controls. The levels of cell-free deoxyribonucleic acid (DNA), citrullinated-histone H3 (cit-H3)-DNA complex and myeloperoxidase (MPO)-DNA complex were quantified using an enzyme-linked immunosorbent assay. DNase I activity was measured using a fluorometric method. The quantifiable levels of cell-free DNA, cit-H3-DNA complex and MPO-DNA complex in the middle ear lavage of patients with OMAAV at onset were significantly higher than those in patients with OMAAV at remission and in patients with OME. DNase I activity in the patients with OMAAV at onset was significantly lower than those in patients with OMAAV at remission and OME, and was negatively correlated with the level of MPO-DNA complex. This study suggests that excessive NET formation and impaired DNase I activity are involved in the pathogenesis of OMAAV. NETs and DNase I activity may be useful biomarkers for the diagnosis and disease activity of OMAAV.
A Greener Biocatalyst promoted Synthesis of Novel pyridine-based Schiff base: Synthesis of their metal complex; In silico molecular docking and In-vitro biological studies and its Photocatalytic dye degradation
Authors: Unjiya Parth , Patel Umang , Rathod Vaishali , Mamtora Mayank , Parmar Hemal , Vaghela Foram , Solanki Mitesh , Shah Manish K. 
Published: October 2023

Abstract
In the present study a series of new Pyridine based schiff bases were synthesized by natural acid that was extracted from certain citrus fruits. By using a metal salt of NiCl2×6H2O, CoCl2×6H2O and Na2PdCl4 to synthesized a metal complexes. Structure of these compounds were confirmed by standard study of MS, LC-MS, FTIR, 1H NMR, 13C NMR, TGA, UV-spectroscopy. Antibacterial activity of synthesized molecules was tested against Gram-positive (S. aureus and E. faecalis) and Gram-negative (E. coli and P. aeruginosa) bacterial strains. Co (II), Ni (II) and Pd (II) metal complexes were used for the photocatalytic degradation of Ramazol brilliant blue R (RBBR) dye with the help of UV visible spectroscopy. The staphyloma concourses microbial structure was pre-processed for docking study using the AutoDock-Vina. The mentioned green chemistry techniques are economical, easy to understand, and give more effective extraction while showing maximum efficiency.
Serum exosomes of pregnant and non-pregnant buffaloes revealed protein signatures of conceptus development and events of the non-fertile cycle
Authors: V.R. Jithil , D.T. Vishruta , Tatu Utpal , Dhara Sujoy K. , Ghosh Subrata , Ghosh Jyotirmoy 
Published: October 2023

AbstractExosomes are membrane-bound extracellular vesicles (EVs) that carry proteins, nucleic acids, and lipids in their cargo from the cells of origin. They are detected in circulatory body fluids and are indicated to play significant roles during the establishment of pregnancy in humans and animals. This study aimed to isolate, quantify, profile, compare, and identify the elected differentially expressed serum exosome proteins in cycling and early-pregnant buffaloes. Serum exosomes were isolated from 0.5 mL serum of non-pregnant day 0, day 10, and day 15 of the cycle (n = 6), and early pregnancy days 15, day 30, and day 60 (n = 5) buffaloes by precipitation method. The proteins of serum exosomes were harvested by sonication, passing through Sephadex G25 spin columns, quantified, and analyzed by one-(1D) and two-dimensional (2D) SDS-PAGE gel electrophoresis. Selected differentially expressed proteins were analyzed by mass spectrometry and generated peptide mass (m)/charge (z) ratio searched against NCBI cattle and buffalo database to identify the protein. The results indicated serum exosome protein on cycle day 10 was significantly lower than the tested other days of the cycle and early pregnancy samples. The 1D electrophoresis did not reveal any difference but the 2D analysis revealed subtle differences. Mass spectrometry analysis of 9 up-regulated spots (8 pregnancy-specific and one cycle-specific) identified 19 proteins under 11 categories by database search. They were functionally related to mitosis, cell cycle regulation, morphogenesis, and regulation of several cellular and molecular pathways which are essential for conceptus development. Out of 19 proteins 17 were found functionally interconnected due to their common properties indicating their importance during the period of critical period of cycle and early pregnancy. In summary, serum exosomes of pregnant and non-pregnant buffaloes revealed protein signatures of conceptus development and events of the non-fertile cycle.
An Assessment of Marine Turtle Nesting Rookeries in the Southern Atlantic Coastline of Cameroon: Implications for Management and Conservation
Authors: Abi Henry Nibam , Avin Ohiana.Revuelta , Fretey Jacques , Tomas Jesus 
Published: October 2023

Abstract
In the present study, we evaluate for the first time marine turtle nesting activity on the coastal beaches of Ebodje, South Region of Cameroon. Regular surveys were carried out over 27 km of coastline in 2013 and over a lesser zone of the studied area with less survey effort from 2014 to 2017. Three marine turtle species were detected nesting in these beaches: the olive ridley (Lepidochelys olivacea), the leatherback turtle (Dermochelys coriacea), and more rarely the green turtle (Chelonia mydas). According to interviews with local inhabitants, the coastal waters of this area are also important for juvenile green turtles and hawksbills (Eretmochelys imbricate) on feeding grounds. Nesting activity concentrates between October and March, with very rare nesting activity detected out of this period. In four nesting seasons, we detected a total of 310 nesting activities, from which 179 clutches were successful; olive ridley was by far the most abundant species (164 clutches), followed by leatherback (11 clutches) and green turtle (4 clutches). The estimated number of olive ridleys in the first nesting season ranged from 30 to 46 turtles. We included information on turtle biometrics and clutch parameters for comparison with closer nesting roockeries and contextualized them with information on human-related threats. Detected threats facing the species were bycatch in artisanal fisheries, beach erosion, light pollution in some beaches, and illegal harvesting of eggs and nesting females at beaches. To mitigate some of these threats, a hatchery was developed on the beach with the highest density of nesting activity. Although there is scarce information about southern Cameroon marine turtle nesting stocks, the levels of nesting and the information on anthropogenic threats reported here indicate that this breeding aggregation is a serious threat and that conservation initiatives are mandated here.
Evaluation of led light on transgenic Nicotiana benthamiana production of a recombinant antibody fragment scFvanti-BAP1.
Authors: Gomes Marinna , Aragão Matheus , Pereira Hyago , Mattos Elyabe , Peixoto Paulo , Martins Marta , Santos Marcelo 
Published: October 2023

Abstract
Plants are an important alternative to produce monoclonal antibodies (mAbs). Although, the plant-based platform still faces several hurdles, that include the choice of plant species to be transformed, the development of suitable plant culture conditions, the genetic lineage of the plant, and the prevention of gene silencing. All of these challenges hinder the enhancement of recombinant productivity. Considering all steps in mAb production, its costs per protein gram are equivalent to that obtained using Chinese hamster ovary cells (CHO cells). Therefore, the construction of a system that optimizes some of these parameters would be welcome. Thus, the development of systems that increase protein production in plant cells are welcome. In the present work, we evaluated three different lineages of a transgenic plant producing mAb scFv-anti-BAP1 under different light conditions. Morphological characteristics, gDNA level and quantitative gene expression were monitored to evaluate the light effects in recombinant protein production. We found that White/Deep Red light increases the total soluble protein production in plants, as well as recombinant yield.
The causal relationship between C-reactive protein and idiopathic pulmonary fibrosis: A univariate and multivariate Mendelian randomization study
Authors: Yang Qiuping , Chen Xuefen , Zhang Yuhhua , Wu Qi 
Published: October 2023

Abstract
Background
This study employs univariate and multivariate Mendelian randomization designs, utilizing publicly available Genome-Wide Association Study (GWAS) data, to assess the causal relationship between C-reactive protein (CRP) and idiopathic pulmonary fibrosis (IPF).
Methods
We obtained IPF GWAS summary statistics (1028 cases and 196,986 controls) from the FinnGen Consortium (r5) and CRP, BMI, and ever-smoked summary statistics from IEU. The primary approach used was the inverse-variance weighted (IVW) method, supplemented by MR-Egger, weighted median and MR-PRESSO methods. Sensitivity analyses, including tests for heterogeneity, horizontal pleiotropy, and leave-one-out analysis, were also conducted.
Results
Mendelian Randomization (MR) analysis reveals a significant causal effect of genetically predicted CRP on IPF (IVW: OR 1.446, 95%CI 1.128–1.854, P = 0.004). This association remains significant after adjusting for BMI and smoking (OR 1.533, 95%CI 1.194–1.96, P < 0.001; OR 1.432, 95%CI 1.129–1.817, P = 0.003, respectively), with no evidence of heterogeneity or horizontal pleiotropy. Sensitivity analyses confirm the stability and reliability of our findings.
Conclusion
Our findings support a causal relationship between CRP and IPF, emphasizing the importance of monitoring femoral neck IPF in patients with chronic inflammatory conditions. Further research is needed to validate our conclusions and elucidate the underlying biological mechanisms. These discoveries provide valuable insights into the pathogenesis and potential future therapies for IPF.
Avoidant/Restrictive Food Intake Disorder and Psychiatric Comorbidity: a descriptive cross sectional study of a tertiary care hospital
Authors: Rodrigues Márcia , Sá Teresa , Mansilha Helena 
Published: October 2023

Abstract

Background: Avoidant/restrictive Food Intake Disorder (ARFID) is a heterogeneous psychiatric disorder that describes a group of patients with avoidant or restrictive eating behaviors unrelated to body image disorder or weight loss desire. Our purpose is to characterize clinical and psychiatric dimensions in children and adolescents diagnosed with ARFID.
Methods: A descriptive cross-sectional study was completed on patients under 17-years and 364 days that were assessed in a specialized consultation at the Nutrition Unit of CMIN between january 2023 and june 2023.
Results: Of the 46 children and adolescents diagnosed of ARFID, 60.9% (n=28), were male and the mean age of our population was 6.3 years (SD=3.8; range=0.8–15.9 years). Most patients presented symptoms from an early age: especially between 18 and 24 months (23.9%, n=11). The mean duration of symptoms prior to diagnosis of ARFID at the Nutrition Unit was 51.8 months (SD = 39.6; range = 2–158 months). The groupings of the ARFID patients included 71.9% (n=34) with difficulties associated with the sensory characteristics of qualities of food; 17.4% (n=8) with lack of interest in eating or food and 8.7% (n=4) with a previously conditioned negative response associated with food intake. In terms of psychiatric comorbidity, 82.6 % (n=38) met additional inclusion criteria for other formal Diagnostic and Statistical Manual of mental disorders 5th edition, text revision (DSM-5-TR) comorbid psychiatric diagnosis. Of these, 63.2% (n=24) had two or more comorbid diagnoses. The most frequent comorbidity was with Autism Spectrum Disorder plus Global Developmental Delay which occurred in 23.7% (n=9) of the population with other diagnosis than ARFID, followed by Sensory Processing Disorder plus Global Developmental Delay diagnosed in 15.8% (n=6) and Autism Spectrum Disorder plus Intellectual Developmental Disorder (10.5%, n=4).
Discussion/Conclusions: Our results underscore the neurodevelopment comorbidity among individuals with ARFID, and highlight the potential shared psychopathology between specific ARFID characteristics and other psychiatric dimensions that may be relevant for treatment.
An unusual case of Isolated piemeningeal hemangioma in a child with significantly elevated cerebrospinal fluid protein in Sturge–Weber syndrome (Type III)
Authors: Zhu Jicai , Hu Yulei , Liu Ailin , Su Lina , Guo Cheng , Ma Mingmin , Xiong Caiyun , Ju Yan , Chen Xiaofang , Tang Chunhui 
Published: October 2023

Abstract
Background: Sturge-weber syndrome is a rare congenital neurocutaneous disorder. Its main feature is facial and meningeal hemangioma. Sturge-weber syndrome may present pial meningeal hemangioma but no facial hemangioma in a small number of patients. However, in children with Sturge-Weber syndrome disease, only cerebral hemangioma, but no facial hemangioma, and elevated cerebrospinal fluid protein level have not been reported.
Case presentation: A Chinese male children presented with leptomeningeal angiomatosis,seizure, the protein level of cerebrospinal fluid increased significantly and no facial hemangioma and ophthalmic symptom. The imaging examination were consistent with the diagnostic criteria of Sturge-Weber syndrome.
Conclusions: We report a case of Sturge-Weber syndrome with cerebral hemangioma but no facial hemangioma and a significant increase in cerebrospinal fluid protein.
An Innovative Approach for Text Document Identification through Word Clouds technique
Authors: Khandagale Sachin , Kurundkar Gajanan , Tathe Rajkumar , Kawade Dipak 
Published: October 2023

Abstract
Text is a versatile and valuable approach to conveying information and knowledge. Unstructured data, however, poses challenges when it comes to reading and extracting valuable information. Users cannot find their subject domains within a matter of seconds without reading them at all. To accurately determine the category of a document or text data, the user must identify the presence of certain key sections in the document. So, text analysis is required to get hidden features from data. Word cloud is one of the important tools in machine learning useful for summarizing and visualizing important words and themes. It can extract relevant features necessary for categorizing text documents into appropriate themes. In this study, we use a document identification approach based on word clouds. Present study uses various news for identification purpose which were downloaded from different newspaper websites. People can find their topics in seconds without even reading them. This study provides numerous interactive graphics and robust, customizable features to help understand the subject of a document.