bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Fused Isoxazoles of Iodoquinol as in vitro EGFR Aiming Anticancer Agents
Authors: Bokkala Karthik , Bapuram Ashok Kumar , Thirukovela Narasimha Swamy , Nukala Satheesh Kumar 
Published: January 2024

AbstractWe have presented the synthesis of some new quinoline linked fused isoxazoles via copper (I) catalyzed azide alkyne cycloaddition (CuAAC) followed by intramolecular C−H arylation of isoxazole ring using PdCl2(PPh3)2 catalyst. All the synthesized compounds were investigated for anticancer activity against three human breast cancer cell lines such as MCF‐7, MDA‐MB‐468 and MDA‐MB‐231 using MTT assay and 5‐fluorouracil (5‐FU) was used as a standard drug. In this study, three compounds were exhibited greater activity than reference drug 5‐FU against three cell lines which further screened for in vitro tyrosine kinase EGFR inhibition and molecular docking studies by taking EGFR protein as the target. Finally, insilico pharmacokinetic profile of the same compounds was obtained using SWISSADME where two compounds following Lipinski, Ghose, Veber, Egan, and Muegge rules.
Mold Resistance of Bamboo after Laccase‐Catalyzed Fixation of Lignin Nanoparticles
Authors: Amat Marshallanore , Chin Suk Fun , Seng Ngieng Ngui , Effendi Wasli Mohd , Husaini Awang Ahmad Sallehin Awang 
Published: January 2024

AbstractIn this study lignin nanoparticles (LNPs) and iodolignin nanoparticles (ILNPs) were prepared in aqueous medium and subsequently deposited on the bamboo surfaces via laccase catalyzed reaction. The SEM micrographs of blocks treated with LNPs and ILNPs revealed a layer of nanoparticles with a mean particles size of 100 nm and 215 nm. Besides that, the fungal isolates from the bamboo culm of Dendrocalamus asper shared 99 %, 98 % and 100 % similarity with Penicillium sumatrense, Pleosporales and Cunninghamella species. The treatment of ILNPs exhibited maximum biocidal efficacy at 91 % against P. sumatrense, Pleosporales sp. and Cunninghamella sp. After leaching with ultrapure water, LNPs‐treated blocks exhibited a reduced biocidal effectiveness with an efficacy of 67 %. In contrast, bamboo treated with ILNPs exhibited a higher level of resistance to decay than LNPs. The reduction in mass of 2 %, 3 %, and 1 % was observed when subjecting P. sumatrense, Cunninghamella, and Pleosporales species to treatment with ILNPs. This study demonstrates the application of laccase catalysis in both LNPs and ILNPs, indicating a potentially effective approach for providing surface protection to bamboo against plant pathogenic fungi.
Activated tyrosine kinase c‐Src‐responsive artificial gene carrier: in vitro and in vivo evaluation
Authors: Terada Keiko , Asai Daisuke , Kang Jeong‐Hun , Mori Takeshi , Katayama Yoshiki 
Published: January 2024

AbstractThe proto‐oncogene c‐Src is a protein‐tyrosine kinase that is associated with increased risk of acute and chronic kidney diseases, cardiovascular diseases, neurological diseases, and cancers. The purpose of this study was to develop a gene delivery carrier responding to activated c‐Src and to evaluate its efficacy in vitro and in vivo. The polymeric gene carrier consists of a neutral main chain bearing a peptide substrate of c‐Src or negative control peptide. Complexes of the polymer containing c‐Src‐targeting peptides and DNA were phosphorylated in the presence of c‐Src, resulting in release of the DNA. Green fluorescent protein (GFP) expression was observed after microinjection of complexes of polymer containing c‐Src‐targeting peptides and GFP‐encoding DNA into A431 cells at the nitrogen/phosphate (N/P) ratio of 1.0. GFP was not expressed in cells microinjected with negative control polymer/DNA complex. Direct injection of complexes of polymer containing c‐Src‐targeting peptides and luciferase‐encoding DNA at N/P ratios of 1.0 and 2.0 into tumor‐bearing mice resulted in luciferase expression in A431 tumors but not in normal skin tissues. No luciferase expression was observed in A431 tumors or skin tissues after injection of control polymer/DNA complex. These results indicate that our gene delivery carrier enables activated c‐Src‐specific gene expression.
Enhancing Phase Transition Temperature in Novel Crown Inclusion Materials through Anion‐Substitution Engineering
Authors: Cai Zhuoer E. , Hua Xiu‐Ni , Shi Xian , Zhang Xiang , Zhang Yinan N. , Chen Jian , Zhang Xinyi Y. , Xiao Shiyue Y. , Sun Baiwang W. 
Published: January 2024

AbstractHost‐guest inclusion materials serve as an ideal model for designing phase transition materials. The typical host molecule, 18‐crown‐6 (1, 4, 7, 10, 13, 16‐hexaoxacyclo‐octadecane), is known for its strong coordination with amino compounds through N−H⋅⋅⋅O hydrogen‐bonding interactions, attracting the attention of numerous scientific researchers. This study presented the successful synthesis and characterization of two host‐guest inclusion materials, [(trans‐4‐aminocyclohexanol)(18‐crown‐6)][ClO4] (1) and [(trans‐4‐aminocyclohexanol)(18‐crown‐6)][BF4] (2). Both compounds 1 and 2 underwent reversible phase changes at temperatures of 312 K/305 K and 322 K/314 K, respectively. In this article, crystal structures, thermal properties, optical properties and analyses of intermolecular interactions were discussed in details. Our endeavors are believed to have made a contribution to the advancement of phase change materials.
Pt Single‐Atoms on Structurally‐Integrated 3D N‐Doped Carbon Tubes Grid for Ampere‐Level Current Density Hydrogen Evolution
Authors: Pan Qijun , Wang Yuguang , Chen Bin , Zhang Xiang , Lin Dou , Yan Sisi , Han Fangming , Zhao Huijun , Meng Guowen 
Published: January 2024

AbstractTo date, the excellent mass‐catalytic activities of Pt single‐atoms catalysts (Pt‐SACs) toward hydrogen evolution reaction (HER) are categorically confirmed; however, their high current density performance remains a challenge for practical applications. Here, a binder‐free approach is exemplified to fabricate self‐standing superhydrophilic‐superaerphobic Pt‐SACs cathodes by directly anchoring Pt‐SAs via Pt‐NxC4‐x coordination bonds to the structurally‐integrated 3D nitrogen‐doped carbon tubes (N‐CTs) array grid (denoted as Pt@N‐CTs). The 3D Pt@N‐CTs cathode with optimal Pt‐SACs loading is capable of operating at a high current density of 1000 mA cm−2 with an ultralow overpotential of 157.9 mV with remarkable long‐term stability over 11 days at 500 mA cm−2. The 3D super‐wettable free‐standing Pt@N‐CTs possess interconnected vertical and lateral N‐CTs with hierarchical‐sized open channels, which facilitates the mass transfer. The binder‐free immobilization adding to the large surface area and 3D‐interconnected open channels endow Pt@N‐CTs cathodes with high accessible active sites, electrical conductivity, and structural stability that maximize the utilization efficiency of Pt‐SAs to achieve ampere‐level current density HER at low overpotentials.
Spontaneous Formation of Ultrasmall Noble Metal Nanoparticles on Cobalt‐Based Layered Double Hydroxide for Electrochemical and Environmental Catalysis
Authors: Chen Qian , Cao Peisheng , Wang Yanying , Yuan Jing , Wu Peng 
Published: January 2024

AbstractSupported noble metal nanoparticles (NMNPs) are appealing for energy and environment catalysis. To facilitate the loading of NMNPs, in situ reduction of Mn+ on the support with extra reductants/surfactants is adopted, but typically results in aggregated NMNPs with uneven size distributions or blocked active sites of the NMNPs. Herein, the use of cobalt layered double hydroxide (Co‐LDH) is proposed as both support and reductant for the preparation of supported NMNPs with ultrasmall sizes and even distributions. The resultant Co‐LDH‐supported NMNPs exhibit excellent catalytic performance and stability. For example, Ir/Co‐LDH displays a low overpotential of 188 mV (10 mA cm−2) for electrocatalytic oxygen evolution reaction and a long‐term stability over 100 h (100 mA cm−2) in overall water splitting. Ru/Co‐LDH can achieve a 4‐nitrophenol reduction with high rate of 0.36 min−1 and S2− detection with low limit of detection (LOD) of 0.34 µm. Overall, this work provides a green and effective strategy to fabricate supported NMNPs with greatly improved catalytic performances.
Tailoring Subthreshold Swing in A‐IGZO Thin‐Film Transistors for Amoled Displays: Impact of Conversion Mechanism on Peald Deposition Sequences
Authors: Yoon Seong Hun , Cho Jae Hun , Cho Iaan , Kim Min Jae , Hur Jae Seok , Bang Seon Woong , Lee Heung Jo , Bae Jong Uk , Kim Jiyoung , Shong Bonggeun , Jeong Jae Kyeong 
Published: January 2024

AbstractAmorphous IGZO (a‐IGZO) thin‐film transistors (TFTs) are standard backplane electronics to power active‐matrix organic light‐emitting diode (AMOLED) televisions due to their high carrier mobility and negligible low leakage characteristics. Despite their advantages, limitations in color depth arise from a steep subthreshold swing (SS) (≤ 0.1 V/decade), necessitating costly external compensation for IGZO transistors. For mid‐size mobile applications such as OLED tablets and notebooks, it is important to ensure controllable SS value (≥ 0.3 V/decade). In this study, a conversion mechanism during plasma‐enhanced atomic layer deposition (PEALD) is proposed as a feasible route to control the SS. When a pulse of a diethylzinc (DEZn) precursor is exposed to the M2O3 (M = In or Ga) surface layer, partial conversion of the underlying M2O3 to ZnO is predicted on the basis of density function theory calculations. Notably, significant distinctions between In‐Ga‐Zn (Case I) and In‐Zn‐Ga (Case II) films are observed: Case II exhibits a lower growth rate and larger Ga/In ratio. Case II TFTs with a‐IGZO (subcycle ratio of In:Ga:Zn = 3:1:1) show reasonable SS values (313 mV decade−1) and high mobility (µFE) of 29.3 cm2 Vs−1 (Case I: 84 mV decade−1 and 33.4 cm2 Vs−1). The rationale for Case II's reasonable SS values is discussed, attributing it to the plausible formation of In‐Zn defects, supported by technology computer‐aided design (TCAD) simulations.
Helium Ion‐Assisted Wet Etching of Silicon Carbide with Extremely Low Roughness for High‐Quality Nanofabrication
Authors: Wen Xiaolei , Zhang Lansheng , Wang Xiuxia , Chen Lin , Sun Jian , Hu Huan 
Published: January 2024

AbstractSilicon carbide (SiC) is a promising material for a wide range of applications, including mechanical nano‐resonators, quantum photonics, and non‐linear photonics. However, its chemical inertness poses challenges for etching in terms of resolution and smoothness. Herein, a novel approach known as helium ion‐bombardment‐enhanced etching (HIBEE) is presented to achieve high‐quality SiC etching. The HIBEE technique utilizes a focused helium ion beam with a typical ion energy of 30 keV to disrupt the crystal lattices of SiC, thus enabling wet etching using hydrofluoric acids and hydrogen peroxide. The etching mechanism is verified via simulations and characterization. The use of a sub‐nanometer beam spot of focused helium ions ensures fabrication resolution, and the resulting etched surface exhibits an extremely low roughness of ≈0.9 nm. One of the advantages of the HIBEE technique is that it does not require resist spin‐coating and development processes, thus enabling the production of nanostructures on irregular SiC surfaces, such as suspended structures and sidewalls. Additionally, the unique interaction volume of helium ions with substrates enables the one‐step fabrication of suspended nanobeam structures directly from bulk substrates. The HIBEE technique is expected to facilitate and accelerate the prototyping of high‐quality SiC devices.
Development of a simple and fast method named solvent‐assisted dispersive solid phase extraction for trace detection of triazole fungicides in water, fruit, vegetable, and agricultural soil samples
Authors: Aladaghlo Zolfaghar , Sahragard Ali , Fakhari Alireza 
Published: January 2024

AbstractSolvent‐assisted dispersive solid‐phase extraction (SA‐DSPE) approach was developed to measure triazole fungicides (TFs). In the SA‐DSPE technique, the addition of 1000 μL of ethanol as a disperser solvent, along with a small quantity of benzil as a sorbent to the sample solution, led to a cloudy solution. After completion of the extraction, the mixture was subjected to centrifugation to isolate benzil. Next, benzil was dissolved in ethanol, and the resulting solution was subsequently analyzed by a gas chromatography‐flame ionization detector. This method demonstrated high linearity (R2 > 0.9963) and repeatability (relative standard deviation % < 4.3) for the quantification of TFs under the optimal conditions (sorbent: benzil, amount of benzil: 2% w/v, pH of solution: 7.0, disperser solvent: ethanol, volumes of ethanol: 1000 μL, centrifuge time: 3 min, extraction temperature: 25°C, and ionic strength: without salt addition). The proposed SA‐DSPE yielded detection limits, quantification limits, and preconcentration factors within the ranges of 0.3–0.9 ng/mL, 1.0–3.0 ng/mL, and 419–426, respectively. Finally, the validated method was employed to determine TFs in a diverse range of real samples, encompassing waters, fruits, vegetables, and agricultural soils, with relative recoveries ranging from 93.0% to 104%.
Ermüdungsfestigkeit am Nahtende im rechnerischen Lichte der neuen Normen EN 1993‐1‐9 und EN 1993‐1‐14
Authors: Lang Robert 
Published: January 2024

AbstractFür Stahlbauteile im Bauwesen ist der Ermüdungsnachweis in EN 1993‐1‐9 geregelt. Diese Norm stellt de facto nur den Nachweis mit Nennspannungen zur Verfügung. Andere Nachweisformate wie das Strukturspannungskonzept sind nur teilweise oder nicht vorhanden. Mit Einführung der neuen EN 1993‐1‐9 sowie der EN 1993‐1‐14 werden neue Konzepte möglich, die sich bislang auf weiterführende Fachliteratur beschränkten. Für den Anwender stellt sich alsbald die Frage, welches Konzept geeignet, anwendbar und auch wirtschaftlich ist. Während für übliche T‐Stöße weitergehende Untersuchungen bereits getätigt wurden, sind für das ebenfalls bemessungsrelevante Schweißnahtende kaum umfangreiche vergleichende Parameterstudien vorhanden. In diesem Aufsatz wird dies nachgeholt.
Application of optimization‐based regression analysis for evaluation of frost durability of recycled aggregate concrete
Authors: Esmaeili‐Falak Mahzad , Sarkhani Benemaran Reza 
Published: January 2024

AbstractConcrete constructed using recycled aggregates in place of natural aggregates is an efficient approach to increase the construction sector's sustainability. To improve recycled aggregate concrete () technologies in permafrost, it is essential to certify the stability in frost‐induced conditions. The main goal of this study was to use support vector regression () methods to forecast the frost durability () of on the basis of durability agent value in cold climates. Herein, three optimization methods called Ant lion optimization (), Grey wolf optimization (), and Henry Gas Solubility Optimization () were employed for indicating optimal values of key parameters. The results depicted that all developed models have capability in predicting the of in cold regions. The values of as a comprehensive index depicted that the model has the higher value at 0.0571 as the weakest model, then at 0.0312 recognized as the second‐highest model, and finally the system at 0.0224 mentioned as outperformed model. and approaches were likewise capable of accurately forecasting the of in cold regions, but the created method outperformed them all when taking into account the explanations and justifications.
Activated sodium bentonite as an adsorbent for efficient removal of hexavalent chromium: Statistical optimization using Box–Behnken design
Authors: Bekele Tadele , Worku Zemene , Duguma Abu , Myneni Venkata Ratnam 
Published: January 2024

AbstractAt present, developing countries, including Ethiopia, are undergoing a phase of industrial transformation. As a result, there has been a significant rise in the presence of harmful pollutants in groundwater. The release of deleterious heavy metals, such as Cr (VI), into the surrounding ecosystem is a result of various industrial operations. The present investigation utilized activated sodium bentonite clay as an adsorbent agent to facilitate the elimination of Cr (VI). The clay was subjected to acidification and thermal modification techniques to enhance its adsorption capacity. The investigation involved an examination of the particular surface area, capacity for cation exchange, crystalline properties, functional groups on the surface, and structural morphology. The methylene blue test method was employed to ascertain the maximum specific surface area and cation exchange capacity of the adsorbent, which were found to be 512 m2/g and 65.5 meq/100 g, respectively. The clay mineral composition was analyzed using X‐ray diffraction, which indicated that the primary constituent was montmorillonite. The presence of impurities such as quartz, feldspar, muscovite, cristobalite, and hematite was also detected. The study employed response surface methodology, Box–Benkhen design (RSM‐BBD) to investigate the impact of operational parameters, including agitation time, initial Cr (VI) concentration, and adsorbent dosage. Under the optimal conditions, a removal efficiency of 98.05% was achieved for Cr (VI) for a contact duration of 120 min, a dosage of 3.913 g/L, and an initial concentration of 50 mg/L. The sodium bentonite clay that was activated demonstrated a maximum capacity for adsorption of 22.72 mg/g in regards to the adsorption of Cr (VI). The experimental data were best fitted by the Langmuir isotherm, which exhibited a correlation coefficient of 0.9699. The adsorption kinetics were assessed and determined to adhere to a pseudo‐second‐order pattern, exhibiting a coefficient of determination (R2) value of 0.999. Furthermore, the activated sodium bentonite clay demonstrated remarkable potential for repeated utilization in the adsorption of Cr (VI) ions in aqueous solutions.
Management of medically unresponsive detrusor urethral dyssynergia in three dogs by perineal urethrostomy
Authors: Picón Sámar Riziq , Macdonald Nicholas , Smith Peter M. , Burrow Rachel 
Published: January 2024

AbstractThree male dogs were referred with chronic dysuria. A presumptive diagnosis of idiopathic detrusor urethral dyssynergia was made based on a characteristic pattern of urination (a ‘spurting’ interrupted urine stream, dribbling urine following failed attempts at urination), normal clinical and neurological examination, absence of physical obstruction on urethral catheterisation and absence of abnormalities on plain and contrast radiography and ultrasonography. Medical management failed to resolve clinical signs, and all dogs therefore underwent perineal urethrostomy as a salvage procedure. There were no major postoperative complications, and all dogs urinated with a normal uninterrupted stream of urine at their first urination postoperatively. Urinary function was assessed before and after perineal urethrostomy by observation of urination and estimation of residual bladder volume using ultrasound. No recurrence of dysuria was reported during long‐term follow‐up, with urination reported to be normal in all cases.
‘To Read in an Indian Way’ (Johann Gottfried Herder): Pre-Emergent Colonial Epistemologies in Indian–German Entanglements, Showcased in Protestant Theology c.1800
Authors: Wiesgickl Simon 
Published: January 2024

AbstractIn this chapter, Simon Wiesgickl shows how, by the end of the eighteenth century, new epistemologies and a newWissenschaftlichkeitwere forming part of the colonial set-up in Germany. He discusses German identity by drawing comparisons between German and foreign cultures, with a focus on the theological discussions that were so central to many debates on German identity. He explains how Johann Gottfried Herder extolled the beauty and value of the Hebrew language and used new ideas and notions of India in his innovative interpretation of the Hebrew Bible as an introduction to the Orient. Herder identified the spirit of poetry and the ‘childhood of mankind’ with the Orient, especially India. By ‘reading in an Indian way’, Herder inspired the German debate about its origin and paved the way for a new ethnographic understanding of the Hebrew Bible. Eventually, he also helped to craft a picture of Indians as noble savages who were mild, close to nature, and fully sensuous.
Probing holographic flat bands at finite density
Authors: Grandi Nicolás , Juričić Vladimir , Landea Ignacio Salazar , Soto-Garrido Rodrigo 
Published: January 2024

Abstract
Flat band electronic systems exhibit a rich landscape of correlation-driven phases, both at the charge neutrality and finite electronic density, featuring exotic electromagnetic and thermodynamic responses. Motivated by these developments, in this paper, we explicitly include the effects of the chemical potential in a holographic model featuring approximately flat bands. In particular, we explore the phase diagram of this holographic flat band system as a function of the chemical potential. We find that at low temperatures and densities, the system features a nematic phase, transitioning into the Lifshitz phase as the chemical potential or temperature increases. To further characterize the ensuing phases, we investigate the optical conductivity and find that this observable shows strong anisotropies in the nematic phase.
A Note on Secant-Defective Varieties and Clifford Modules
Authors: Nash Oliver 
Published: January 2024

AbstractWe generalise a construction of Landsberg, which associates certain Clifford algebra representations to Severi varieties. We thus obtain a new proof of Russo’s Divisibility Property for LQEL varieties whose secant varieties do not fill the ambient space. We also make an observation about the question of whether there exists a smooth, irreducible, non-degenerate, projective variety with secant deficiency $$\delta > 8$$

δ
>
8

.
Referenzauswertungen für die Schätzung von Prävalenz, Inzidenz und Mortalität Public-Health-relevanter Erkrankungen auf Basis von Routinedaten
Authors: Krause Laura , Reitzle Lukas , Hess Steffen , Ziese Thomas , Adewuyi Davis 
Published: January 2024

ZusammenfassungDie Routinedaten aller gesetzlich Krankenversicherten nach Datentransparenzverordnung (DaTraV-Daten) stellen eine vielversprechende Datenquelle für die wiederkehrende und zeitnahe Surveillance nicht-übertragbarer Erkrankungen (NCD) in Deutschland dar. Dabei hat sich gezeigt, dass ein hoher Bedarf für Referenzauswertungen besteht, die schnelle und regelmäßig wiederholbare Analysen zu wichtigen NCD ermöglichen. Vor diesem Hintergrund wurde „ReFern-01“ initiiert, ein gemeinsames Projekt vom Robert Koch-Institut (RKI) und dem Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM). In Zusammenarbeit mit Expert:innen aus dem Bereich der Sekundärdatenanalyse und Versorgungsforschung wurden Referenzauswertungen zur Schätzung von Prävalenz, Inzidenz und Mortalität für wichtige Public-Health-relevante Erkrankungen erarbeitet. Zunächst wurden mittels einer Onlinebefragung 11 zentrale NCD ausgewählt und in Zusammenschau mit einer Literaturrecherche initiale Falldefinitionen erstellt. Diese wurden anschließend in einem virtuellen Workshop diskutiert und konsentiert. Die erstellten Referenzauswertungen (Analyseskripte) ermöglichen eine standardisierte Schätzung der genannten epidemiologischen Kennzahlen, die über die Zeit und regional vergleichbar sind. Neben der Bereitstellung der Ergebnisse werden die Skripte am BfArM für zukünftige Datennutzende zur Verfügung stehen. Mit dem Fernzugang zur Analyse der DaTraV-Daten, der derzeit am Forschungsdatenzentrum Gesundheit (FDZ Gesundheit) aufgebaut wird, können die Ergebnisse des Projekts ReFern die Surveillance von NCD stärken und Public-Health-Akteur:innen beispielsweise bei der Planung und Umsetzung von Maßnahmen der Gesundheitsförderung und Prävention auf Ebene von Bund, Ländern, Kreisen und Kommunen unterstützen.