bluuebunny/crossref_metadata_2025_split huggingface dataset:
N‐Substituted‐5‐ [(2,5‐Dihydroxybenzyl)amino]salicylamides as Lavendustin Analogs: Antiproliferative Activity, COMPARE Analyses, Mechanistic, Docking, ADMET and Toxicity Studies
Authors: Abdu‐Allah Hajjaj H. M. , El‐Nagar Mohamed K. S. , Qayed Wesam S. , Salem Ola I. A. , Kafafy Abdel‐Hamid N. , El‐Awady Raafat , Nicola Mariam A. 
Published: January 2025

ABSTRACTTarget cyclooxygenase 2 (COX‐2) and 5‐lipoxygenase (5‐LOX) inhibitors; 5‐([2,5‐Dihydroxybenzyl]amino)salicylamides (Compounds 1–11) were examined for potential anticancer activity, with a trial to assess the underlying possible mechanisms. Compounds were assessed at a single dose against 60 cancer cell lines panel and those with the highest activity were tested in the five‐dose assay. COMPARE analysis was conducted to explore potential mechanisms underlying their biological activity. In vitro epidermal growth factor receptor (EGFR) inhibitory activity was performed, as well as cell cycle and apoptosis assays, in addition to molecular docking to rationalize the potential of these compounds as potent EGFR inhibitors. The compounds revealed broad‐spectrum anticancer activity against most cancer cell lines, particularly those of leukemia. Compound 9 showed the maximum growth inhibition (99.65%) against leukemia HL‐60 (TB) cell line. Compound 5 produced the uppermost cytotoxic activity (62.28%) against non‐small cell lung cancer cell line (NCI‐H522), and the most potent antiproliferative and cytotoxic activities against the same cell line in the five‐dose assay. Flow cytometry of cell cycle distribution on NCI‐H522 showed arrest of cells at different phases of the cycle by Compounds 4, 5, 9–11. These compounds induced apoptosis in NCI‐H522, particularly Compounds 4 and 5. They showed a remarkable in vitro EGFR inhibitory activity that was comparable to erlotinib, and a predicted ADME pharmacokinetic profile. In conclusion, the N‐substituted aminosalicylamides exhibited considerable anticancer activity. The pattern of N‐substitution is important in their activity. The compounds exhibited polypharmacology; one of the targets is the EGFR, as supported by molecular docking.
Effect of Nonsurgical Mechanical Debridement With or Without Chlorhexidine Formulations in the Treatment of Peri‐Implant Mucositis. A Randomized Placebo‐Controlled Clinical Trial
Authors: Isola Gaetano , Polizzi Alessandro , Santagati Maria , Alibrandi Angela , Iorio‐Siciliano Vincenzo , Ramaglia Luca 
Published: January 2025

ABSTRACTObjectivesTo evaluate the treatment of peri‐implant mucositis (PM) using a nonsurgical submarginal peri‐implant instrumentation (NSPI) with or without chlorhexidine (CHX) solutions.MethodsFifty‐six patients (28 per group) were randomly assigned to the test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing with 1% CHX gel) or the control group (NSPI + placebo mouthwash and subgingival placebo irrigation plus tongue brushing with placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), probing pocket depth (PPD), modified gingival index (mGI), modified plaque index (mPlI), full‐mouth plaque score (FMPS), full‐mouth bleeding score (FMBS), and the proportions of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were recorded. The BOP reduction was set as a primary outcome. Data were analyzed to assess BOP reduction at a 6‐month follow‐up and to identify significant predictors of implant‐site BOP through mixed generalized linear regression.ResultsAfter 6 months in both groups, a significant reduction of BOP, PD, mPlI, mGI, FMBS, and FMPS was noted (p < 0.05). However, at 6 months, the test group was more effective than the controls in reducing median BOP (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 [95% CI 46.5–51.2], p = 0.044), as well as mPlI (p = 0.041) and the proportion of Treponema denticola (p = 0.039). Moreover, the implant‐sites BOP reduction was significantly influenced by test treatment (p < 0.001), history of periodontitis (p = 0.003), and a high number of cigarettes/day (p = 0.002), the proportion of Porphyromonas gingivalis (p = 0.021) and Tannerella forsythia (p = 0.032).ConclusionsNSPI + CHX showed better results compared to placebo in implant‐sites BOP reduction. The high number of cigarettes/day and the proportion of Porphyromonas gingivalis and T. forsythia negatively influenced the BOP reduction in PM‐treated patients.
Long‐Term Clinical Outcomes and Risk Indicator Analyses of Narrow‐Diameter Implants in the Posterior Jaw: A Retrospective Cohort Study of 10 to 27 Years
Authors: Zhu Jingxian , Sun Wei , Yang Shanyi , Du Zhili , Yang Rui , Shi Bin , Ji Wei 
Published: January 2025

ABSTRACTObjectivesTo assess the long‐term clinical outcomes and patient satisfaction with narrow‐diameter implants (NDIs) in the posterior jaws and to identify the risk indicators for NDI failure.Materials and MethodsThis retrospective study reviewed 479 patients with 666 NDIs (diameter ≤ 3.5 mm) ‐supported fixed prostheses in posterior jaws, with a minimum 10‐year follow‐up. Implant survival, success, complications, demographics, and implantation characteristics were collected. Risk indicators for posterior NDI failure were analyzed using multilevel Cox regression analyses with mixed effects. Patient satisfaction and oral health impact profile (OHIP) were surveyed in a random 10% sample.ResultsOver a mean follow‐up of 14.0 ± 3.6 years, implant survival was 95.9% at the implant level and 94.6% at the patient level. Success rates were 93.5% at the implant level and 91.6% at the patient level. Multilevel Cox regression analysis identified an implant length of 10 mm or less (p = 0.001) and the use of single crowns (p = 0.005) as significant risk indicators for posterior NDI failure. Patients showed high satisfaction (4.54/5) with posterior NDIs, and the mean OHIP score of 1.15 reflected an acceptable level of oral health.ConclusionNDIs in the posterior jaws demonstrated robust long‐term success and high patient satisfaction. An implant length of 10 mm or less and the use of single crowns are potential risk indicators for posterior NDI failure.Trial RegistrationChinese Clinical Trial Registry: ChiCTR2200062337 on 2022/08/02
The New‐Meaning Objection: A Reply to Nicolò D'Agruma
Authors: Devitt Michael , Porot Nicolas 
Published: January 2025

AbstractIn our paper, “The reference of proper names” (2018), we raised and rebutted the “New‐Meaning” objection to our methodology. Our rebuttal rested on theoretical considerations and experimental results. In “Do the Gödel vignettes involve a new descriptivist meaning?”, Nicolò D'Agruma provides an interesting argument against our theoretical considerations (but does not address the experimental evidence). Our present paper argues against D'Agruma. So, our original rebuttal of the objection still stands. We offer further evidence against the objection.
Digital Industry Agglomeration and Export Product Diversification: Evidence from Chinese Firms
Authors: Zhan Jinyong , Wang Xinrui , Li Qian , Zhao Jiazhang 
Published: January 2025

AbstractThe rapid development of digital industries such as artificial intelligence and big data has fundamentally transformed production, providing new opportunities for the diversification of firms. Drawing on data from the China Customs Database and the Annual Survey of Industrial Firms for 2003–2013, we employed a panel fixed effects model to examine the impact of digital industry agglomeration on firms' export product diversification. The findings revealed that, holding other conditions constant, a one‐unit increase in digital industry agglomeration resulted in a significant 2.34 percent rise in export scope and a significant decrease by 0.58 percent in export concentration. Firms in digitally advanced cities and capital‐intensive industries were more influenced by digital industry agglomeration in export diversification. Mechanism analysis reveals that digital industry agglomeration fostered export product diversification through innovation stimulation, information dissemination, and efficiency enhancement. Innovation was evidenced by increases in urban innovation indices and the emergence of new export products. Information dissemination boosted wholesale and retail sales, helping firms to expand export destinations. Efficiency enhancement was reflected in narrowing management efficiency gaps among firms.
The Spillover Effects of International Co‐production in the Chinese Film Industry
Authors: Yu Feng , Li Ning , Yan Jing , Zhang Yan 
Published: January 2025

AbstractThis study examines the spillover effects of international film co‐production using data on films released in the Chinese mainland from 2006 to 2018. The results indicate that local film producers can enhance their product performance by leveraging the expertise and practices of more sophisticated foreign firms during international co‐productions. Heterogeneous effects were observed related to budget size, firm size, ownership structure, and cultural distance. These spillover effects can occur through two mechanisms: the demonstration effect (the adoption of more advanced technology) and the labor mobility effect (actors or directors upgrading their skills). An instrumental variable approach is employed to address endogeneity concerns. This study contributes to the spillover effects of international co‐production, which has been neglected in the literature. Its empirical findings suggest that engaging in international co‐production can potentially boost productivity for firms from developing countries. Host country governments may consider offering preferential policies to promote international co‐production as an alternative to foreign direct investment (FDI), thereby fostering positive spillover effects.
Can the Environmental Credit Evaluation Policy Alleviate the Overcapacity of Heavily Polluting Enterprises?
Authors: Sun Chuanwang , Chen Jiahui 
Published: January 2025

AbstractAddressing pollution caused by economic development, especially the overcapacity of polluting enterprises, is crucial for promoting sustainable economic growth. Targeted environmental policies are essential for strengthening environmental constraints on enterprises and enhancing the effectiveness of regulatory instruments. This study focused on the Environmental Credit Evaluation policy by examining its potential to improve capacity utilization and assessing its broader impact on heavily polluting enterprises. It constructed a time‐varying difference‐in‐difference‐in‐differences model using panel data from 965 industrial enterprises from 2009 to 2019. The findings reveal that, in comparison with their non‐heavily polluting counterparts, heavily polluting enterprises subject to the policy demonstrated significant improvements in capacity utilization. Heavily polluting enterprises that experienced a substantial increase in financing costs also exhibited a marked reduction in inefficient investment, without negatively affecting innovation investments or output.
How Does the Belt and Road Initiative Improve China's Product Export Potential: A Global Value Chain Perspective
Authors: Zhang Liang , Fu Dahai , Wu Chengjun , Liu Yuanyuan , Xi Yanle 
Published: January 2025

AbstractThis study examines the impact of the Belt and Road Initiative (BRI) on China's export potential at the product level. Using country–product‐level data from the Centre d'Etudes Prospectives d'Informations Internationales‐Base pour l'Analyse du Commerce International (CEPII‐BACI), which includes 5,049 product types across 196 economies from 2007 to 2022, it explores the trade effects of the BRI and its mechanisms from the perspective of global value chains. The results indicate that the BRI has increased China's product export potential significantly to participating countires. The BRI has had the greatest impact on capital goods and labor‐ and capital‐intensive industries. The effect has been most pronounced in China's exports to Southeast Asia, South Asia, and Europe. The mechanism analysis reveals that the BRI has improved the division of labor in the global value chains for participating countries along the BRI, strengthened China's position in their output supply chains, and stimulated the growth of China's exports.
Do Institutional Investor Cliques Undermine Stock Price Efficiency?
Authors: Jiang Hai , Chen Shuangyi , Wang Zifeng 
Published: January 2025

AbstractThis study investigates the effects of institutional investor cliques on stock price efficiency. Using a community network algorithm, it identifies cliques of institutional investors and finds that they significantly undermined stock price efficiency in China. The robustness of this finding is demonstrated through a range of methodologies, including the substitution of dependent variables, the alteration of estimation methods, the exclusion of data from extreme market periods, and the application of instrumental variables. The role of institutional investor cliques in diminishing market efficiency is attributed to market speculation. The detrimental effect of cliques on efficiency is exacerbated in environments characterized by low stock liquidity, poor information disclosure, and heightened panic among retail investors. However, regulatory interventions, such as inquiry letters, are shown to mitigate these effects and enhance market efficiency. These findings highlight the unexpected ways institutional investor cliques can influence emerging market economies and underscore the critical importance of effective regulation to safeguard market efficiency.
Sonographic features of active Charcot neuro‐osteoarthropathy: A case series
Authors: Pallin Jennifer A. , Lockhart Michael , O'Loughlin Aonghus , Gallagher David , Kearns Stephen R. , Dinneen Sean F. , Bergin Diane 
Published: January 2025

AbstractAimsTo describe the sonographic features of active Charcot neuro‐osteoarthropathy (CNO) and assess the potential role of ultrasound in identifying those with active CNO.MethodsUsing a prospective case‐series study design we assessed the sonographic features of 14 patients with a diagnosis of diabetes presenting with clinical signs and symptoms suspicious for active CNO. Patients had standard weight‐bearing plain X‐Ray and, where possible, MRI to evaluate the presence of active CNO. Ultrasound was performed bilaterally to assess for subcutaneous oedema, intra‐articular and peri‐articular colour flow. The spectral waveform morphology, peak systolic velocity and resistive index of the dorsalis pedis arteries of both feet were also documented.ResultsFollowing clinical and radiological (X‐ray and MRI) assessment, 50% (n = 7) were diagnosed with active CNO. Of those with a confirmed diagnosis, ≥3 sonographic features suggestive of active CNO were observed.ConclusionsUltrasound combined with clinical presentation and medical history may support decision making around the diagnosis of CNO at the bedside.
Unveiling the feeding response of Spodoptera litura to natural host and artificial diet
Authors: Abbas Arzlan , Wei‐Bo Qin , Hafeez Faisal , Hasnain Ali , Shoukat Komal , Ali Jamin , Xiao Feng , Liu Jia‐Li , Ghramh Hamed A. , Khan Khalid Ali , Ullah Farman , Ri‐Zhao Chen 
Published: January 2025

AbstractBehavioral studies play a crucial role in assessing food utilization in insects. However, there exists a gap in our understanding of the phenotypic plasticity in Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) and how it impacts their growth, development, and potential for plant damage. This study aimed to investigate the phenotypic plasticity of S. litura, with a focus on its immature stages, and evaluate the consequences of plant damage and pest management. We conducted in vitro experiments using both a standard artificial diet and tobacco (Nicotiana tabacum L., Solanaceae) plants to assess the growth, development, survival, longevity, reproductive capacity, and egg‐laying capability of S. litura larvae and adults. A type II functional response was estimated for all larval instars, utilizing the Likelihood Holling's Disk model, which provided two key coefficients: the search rate (a) and handling time (Th). Our findings revealed that sixth instars exhibited exceptional agility and efficiency, requiring the shortest time to process each milligram of diet compared with other larval stages. Moreover, when larvae were fed on tobacco, they displayed the shortest developmental time and the highest fecundity. This trend extended to pupal weight, pupal duration, pupal emergence, fecundity, and longevity, which were all significantly higher in individuals fed on tobacco. Additionally, S. litura larvae that fed on tobacco exhibited greater efficiency in converting digested food and lower approximate digestibility compared to larvae fed the artificial diet. These results underscore the importance of focusing on the management of fourth, fifth, and sixth instars, which have the potential to cause severe plant damage. Understanding the functional and nutritional response of S. litura larvae enhances the efficiency of integrated pest management strategies (IPM) at early stages while minimizing ecological impact.
Epilepsy Stands Nearby: A Pilot CT Perfusion Study on Post‐Stroke Non‐Convulsive Status Epilepticus
Authors: Merli Elena , Romoli Michele , Galluzzo Simone , Zaniboni Anna , Testoni Stefania , Contardi Sara , Cece Emanuele Saverio , Nobili Fabio , Matteo Eleonora , Ricci Gabriele , Simonetti Luigi , Zini Andrea 
Published: January 2025

ABSTRACTBackgroundTo investigate the relevance of hyperperfusion on computerised perfusion imaging (CTP) in the emergency setting in people with non‐convulsive status epilepticus (NCSE) and previous stroke, to derive relevant aspects on the epileptogenic focus and the network recruited for NCSE propagation.MethodsWe enrolled consecutive adult patients with acute‐onset NCSE and a previous stroke at a single institution undergoing CTP and EEG during symptoms. All patients underwent standard imaging including CT, CTP, CT angiograms and standard EEG within 30 min from hospital arrival. Age‐/sex‐matched NCSE without previous stroke cases and recurrent ischaemic stroke cases were included to test for accuracy of hyperperfusion rates.ResultsOverall, 15 patients had a previous stroke and developed NCSE (mean age 78 years, 46.7% female). All patients had hyperperfusion on CTP imaging (mean onset‐to‐CTP 184 min). Only one case showed hyperperfusion limited to the previous stroke lesion, and one had a combination of lesional and peri‐lesional hyperperfusion. All remaining cases (n = 13) had exclusive extra‐lesional involvement. Five cases had multiple separated hyperperfused areas, and five had ipsilateral intra‐thalamic hyperperfusion. No correlation emerged between onset‐to‐CTP timing and hyperperfusion (p value for CTP = 0.66, CBV = 0.28, MTT = 0.28, reverse Tmax = 0.66). Hyperperfusion was present in NCSE cases only and in none of age‐/sex‐matched ischaemic stroke cases (n = 18).ConclusionsHyperperfusion involves cortical areas external to the previous lesion site during NCSE, supporting the relevance of networks for the spatial evolution of epileptic activity and limited relevance of the lesion site for the propagation of the epileptiform activity.
Equine temporomandibular joint diseases: A systematic review
Authors: Jasiński Tomasz , Turek Bernard , Kaczorowski Michał , Brehm Walter , Skierbiszewska Katarzyna , Domino Małgorzata 
Published: January 2025

AbstractBackgroundThe temporomandibular joint (TMJ) is a unique joint that enables mandibular movement. Temporomandibular diseases (TMDs) impair joint function, leading to more or less specific clinical signs.ObjectivesTo compile and disseminate clinical data and research findings from existing publications on equine TMD.Study designSystematic review.MethodsFollowing PRISMA 2020 guidelines, literature searches were conducted in PUBMED, Scopus, and Web of Knowledge. The inclusion criteria covered case reports and research articles on equine TMDs. The selected records were grouped considering septic TMJ arthritis, primary TMJ osteoarthritis (OA), and non‐arthritic TMDs. A risk of bias assessment was performed for the research articles.ResultsEquine TMD has been described in 51 publications to date, with septic TMJ arthritis accounting for 41.2% of TMD cases, fractures/luxations for 29.4%, and primary TMJ OA for 21.6%. Trauma was confirmed or suspected in 54.9% of TMD cases. The severity of clinical signs was mild to moderate in primary TMJ OA and mild to severe in septic TMJ arthritis and non‐arthritic TMDs. Clinical signs were related to the underlying cause, particularly in terms of TMJ swelling, pain, and masticatory problems. Among diagnostic imaging modalities, CT was utilised in 92.2% of horses, radiography in 84.4%, and ultrasonography in 21.6%.Main limitationsThe lack of clinical data in some reports. A risk of bias due to missing data.ConclusionsTMDs are infrequently described, with trauma being the most common TMD cause. TMDs are associated with TMJ dysfunction; however, the diagnostic protocol is varied. Regardless of the TMD type, a detailed diagnostic protocol should include a thorough history, detailed TMJ examination, and radiography as the first imaging choice in field practice, with CT as the ‘gold standard’ in clinical settings. For septic TMJ arthritis, a bacterial culture is recommended, while for primary TMJ OA, functional tests and local analgesia.
Assessment of tree‐associated atypical myopathy risk factors in Acer pseudoplatanus (sycamore) seeds and leaves
Authors: González‐Medina Sonia , Hyde Carolyn , Chang Yu‐Mei , Piercy Richard J. 
Published: January 2025

AbstractBackgroundSycamore tree‐derived hypoglycin A (HGA) toxin causes atypical myopathy (AM), an acute, equine pasture‐associated rhabdomyolysis but incidence fluctuates.ObjectivesInvestigate whether tree or environmental factors influence HGA concentration in sycamore material and are associated with AM relative risk.Study designRetrospective and experimental prospective study.MethodsUK sycamore population, seed production and AM incidence data were obtained. HGA concentration was measured in seeds from trees from 10 different central UK locations. The effect of tar spot infection, seed maturity, tree trunk girth, location (urban/countryside), AM cases within 130 m, soil type, facing direction of seeds on the tree and year on seed HGA concentration was examined. HGA concentration was compared in whole and homogenated seeds stored in different ways.ResultsHGA concentration in sycamore seeds was not associated with tree tar spot infection, location, trunk girth, seed weight or branch‐facing direction but HGA concentration in sycamore seeds varied significantly and in parallel year on year in the same trees. Trees in the same vicinity tended to have similar HGA concentrations in their seeds when compared with those from farther afield. Seed production estimates were positively correlated with regional AM case incidence (τb = 0.3; p = 0.007). HGA sycamore seed concentration remained stable as seeds matured, but HGA declined in leaves as they wilted in autumn. Warmer and wet storage resulted in higher HGA concentrations in seed homogenates but not in whole seeds. HGA was detected in water containing sycamore seeds for 48 h.Main limitationsLack of accurate weather data; sampling restricted to central England.ConclusionsTree factors that were investigated did not affect HGA concentration in sycamore seeds but HGA concentrations varied year on year. AM incidence is related to seed production; conditions that mimic browsing and ingestion increased seed HGA concentration. HGA toxicity could occur from contaminated water sources.