bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of graded motor imagery and its components on phantom limb pain in amputated patients: A systematic review
Authors: Rierola-Fochs Sandra , Ochandorena-Acha Mirari , Merchán-Baeza Jose Antonio , Minobes-Molina Eduard 
Published: October 2023

Background:
Phantom limb pain (PLP) can be defined as pain in a missing part of the limb. It is reported in 50%–80% of people with amputation.

Objectives:
To provide an overview of the effectiveness of graded motor imagery (GMI) and the techniques which form it on PLP in amputees.

Study Design:
Systematic review.

Methods:
Two authors independently selected relevant studies, screened the articles for methodological validity and risk of bias, and extracted the data. Inclusion criteria used were clinical studies, written in English or Spanish, using GMI, laterality recognition, motor imagery, mirror therapy, or a combination of some of them as an intervention in amputated patients, and one of the outcomes was PLP, and it was assessed using a validated scale. The databases used were PubMed, Scopus, Web of Science, CINAHL, and PEDro.

Results:
Fifteen studies were included in the review. After the intervention, all the groups in which the GMI or one of the techniques that comprise it was used showed decrease in PLP.

Conclusion:
The 3 GMI techniques showed effectiveness in decreasing PLP in amputees, although it should be noted that the application of the GMI showed better results.
INTERFERING HSA_CIRC_0001226 MITIGATES LPS-INDUCED BEAS-2B CELL INJURY BY REGULATING MIR-940/TGFBR2 PATHWAY
Authors: Mo Song , Yi Qushen , Bei Xuezhu , Huang Yuan , Lai Junhua 
Published: October 2023

ABSTRACTBackground:Sepsis-associated acute lung injury (SA-ALI) is a serious threat to human health. A growing body of evidence suggested that circular RNAs may be involved in ALI progression. The aim of this study was to investigate the effect and mechanism of circ_0001226 on lipopolysaccharide (LPS)–induced BEAS-2B cells.Methods:BEAS-2B cells were stimulated with LPS to establish a SA-ALI cell model. The expression of circ_0001226, miR-940, and transforming growth factor beta receptor II (TGFBR2) were monitored by quantitative real-time polymerase chain reaction. Cell proliferation and apoptosis were evaluated by the Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine assay, and flow cytometry. The levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α were calculated by enzyme-linked immunosorbent assay. Western blot was implemented to test the protein levels of PCNA, Bax, and TGFBR2. Dual-luciferase reporter assay and RNA pull-down assay were adopted to investigate the interaction between circ_0001226 and miR-940, as well as TGFBR2 and miR-940.Results:The levels of circ_0001226 and TGFBR2 were elevated, and miR-940 was decreased in SA-ALI serum specimens and LPS-evoked BEAS-2B cells. Besides that, circ_0001226 interference contributed to cell proliferation and restrained apoptosis and inflammation in LPS-induced BEAS-2B cells. Mechanically, circ_0001226 worked as a molecular sponge of miR-940 to regulate TGFBR2 expression.Conclusion:Circ_0001226 deficiency weakened LPS-mediated proliferation inhibition and inflammatory processes in BEAS-2B cells by binding miR-940 and regulating TGFBR2.
BMI is Not Associated with Chest-Specific Body Image, Complications or Revisions in Gender-Affirming Mastectomy
Authors: Roblee Cole , Topple Tannon , Hamill Jennifer B , Ibarra Maria , Bolze Andrew , Khouri Alexander N , Hsu Jessica J , Lane Megan , Kuzon William M , Wilkins Edwin G , Morrison Shane D 
Published: October 2023

Objective:
To analyze the impact of Body Mass Index (BMI) on clinical and patient-reported outcomes following gender-affirming mastectomy (GM).

Background:
BMI is a barrier for obese patients seeking GM despite increasing evidence that it is safe in this population. Currently little is known about the impact of BMI on chest-specific body image and satisfaction following GM.

Methods:
This single-center, cross-sectional study included individuals 18 years and older who underwent GM between 1990-2020 and were at least 2 years post-operative. Patient-reported chest-specific body image was measured using the BODY-Q and Gender Congruence and Life Satisfaction (GCLS) chest subscales. Satisfaction was measured using the Holmes-Rovner Satisfaction with Decision (SWD) scale. Clinical and demographic variables were identified from chart review. Bivariate analysis was performed to determine if BMI was associated with chest-specific body image, satisfaction, complications within 30 days or revisions in GM.

Results:
Two hundred twenty-seven individuals meeting eligibility criteria were contacted to participate and one hundred thirty-seven responded (60.4% response rate). The mean age was 29.1 (SD=9.0) and mean BMI was 30.9 (SD=8.0), with 26.4% (N=60) of the cohort having a BMI>35. Chest-specific body image, and satisfaction with decision did not vary by BMI or breast resection weight. Complications and revisions were not associated with BMI.

Conclusion:
Individuals undergoing GM reported high rates of satisfaction following GM regardless of BMI. Complication and revision rates did not vary significantly by BMI or breast resection weight. Surgeons should re-evaluate the role BMI plays in patient selection and counseling for GM.
Novel Form of Breast Intraoperative Radiation Therapy with CT-Guided High-Dose-Rate Brachytherapy: Interim Results of a Prospective Phase II Clinical Trial
Authors: Turkheimer Lena M , Petroni Gina R , Berger Adam C , Schroen Anneke T , Brenin David R , Lazar Melissa , Libby Bruce , Janowski Einsley M , Showalter Timothy N , Showalter Shayna L 
Published: October 2023

Introduction:
Precision Breast IORT (PB-IORT) is a novel method of intraoperative radiation therapy (IORT) utilizing customized, computed tomography (CT)-based treatment plans and high-dose-rate (HDR) brachytherapy. We conducted a phase II multi-institution trial to evaluate the efficacy of PB-IORT.

Study Design:
Between 2015 and 2022, three centers enrolled 358 women aged ≥ 45 with invasive or in situ carcinoma measuring 3 cm or smaller and N0 status. Breast-conserving surgery (BCS) was performed, and a multi-lumen balloon catheter was placed in the lumpectomy bed. CT images were used to create a customized HDR brachytherapy plan delivering 12.5 Gy to the tumor bed. The primary outcome assessed was the 5-year rate of index quadrant tumor recurrence (IQTR). An interim analysis was conducted after one-third of eligible participants completed five years of follow-up. This trial is registered with clinicaltrials.gov (NCT02400658).

Results:
The cohort was comprised of 153 participants with a median age of 64 years and a median follow-up time of 5.9 years. The estimated 5-year IQTR rate and overall survival were 5.08% (95% CI 2.23-9.68%) and 95.1%, respectively. Loco-regional (ipsilateral breast and axilla) and distant recurrence rates were each 1.96%. Seven deaths occurred during the first five years of follow-up, with only one attributable to breast cancer. Overall, 68.6% of patients experienced any adverse effects, and four cases of breast-related severe toxicities were observed.

Conclusions:
This study presents the results of a planned interim analysis of a Phase II trial investigating PB-IORT and demonstrates the efficacy and safety of single-fraction, CT-based, HDR brachytherapy following BCS. These findings provide valuable insights into utilizing PB-IORT as a treatment modality.
Household characteristics associated with environmentally persistent free radicals in house dust in two Australian locations
Authors: Lee Wen R , Dangal Prakash , Cormier Stephania , Lomnicki Slawo , Sly Peter D , Vilcins Dwan 
Published: October 2023

AbstractThe association between air pollution and adverse health outcomes has been extensively studied, and while oxidative stress in likely to be involved, the underlying mechanism(s) remain unclear. Recent studies propose environmentally persistent free radicals (EPFRs) as the missing connection between air pollution and detrimental health impacts. However, the indoor environment is rarely considered in EPFR research. We measured EPFRs in household dust from two locations in Australia and investigated household characteristics associated with EPFRs. Random forest models were built to identify important household characteristics through variable importance plots and the associations were analysed using Spearman’s rho test. We found that age of house, type of garage, house outer wall material, heating method used in home, frequency of extractor fan use when cooking, traffic related air pollution, frequency of cleaning and major house renovation were important household characteristics associated with EPFRs in Australian homes. The direction of association between household characteristics and EPFRs differ between the locations. Hence, further research is warranted to determine the generalisability of our results.
Proteomic Insights into Metastatic Breast Cancer Response to Brain Cell-Secreted Factors
Authors: Ahuja Shreya , Lazar Iulia M. 
Published: October 2023

AbstractThe most devastating feature of cancer cells is their ability to metastasize to distant sites in the body. HER2+ and triple negative breast cancers frequently metastasize to the brain and stay potentially dormant for years, clinging to the microvasculature, until favorable environmental conditions support their proliferation. The sheltered and delicate nature of the brain prevents, however, early disease detection, diagnosis, and effective delivery of therapeutic drugs. Moreover, the challenges associated with the acquisition of brain tissues and biopsies add compounding difficulties to exploring the mechanistic aspects of tumor development, leading to slow progress in understanding the drivers of disease progression and response to therapy. To provide insights into the determinants of cancer cell behavior at the brain metastatic site, this study was aimed at exploring the growth and initial response of HER2+ breast cancer cells (SKBR3) to factors present in the brain perivascular niche. The neural microenvironment conditions were simulated by using the secretome of a set of brain cells that come first in contact with the cancer cells upon crossing the blood brain barrier, i.e., human endothelial cells (HBEC5i), human astrocytes (NHA) and human microglia (HMC3) cells. Cytokine microarrays were used to investigate the cell secretomes and explore the mediators responsible for cell-cell communication, and proteomic technologies for assessing the changes in the behavior of cancer cells upon exposure to the brain cell-secreted factors. The results of the study suggest that the exposure of SKBR3 cells to the brain secretomes altered their growth potential and drove them towards a state of quiescence. The cytokines, growth factors and enzymes detected in the brain cell-conditioned medium were supportive of mostly inflammatory conditions, indicating a collective functional contribution to cell activation, defense, inflammatory responses, chemotaxis, adhesion, angiogenesis, and ECM organization. The SKBR3 cells, on the other hand, secreted numerous cancer-promoting growth factors that were either absent or present in lower abundance in the brain cell culture media, suggesting that upon exposure the SKBR3 cells were deprived of favorable environmental conditions required for optimal growth. The findings of this study underscore the key role played by the neural niche in shaping the behavior of metastasized cancer cells, providing insights into the cancer-host cell cross-talk that contributes to driving metastasized cancer cells into dormancy and into the opportunities that exist for developing novel therapeutic strategies that target the brain metastases of breast cancer.
Integration of shoot-derived polypeptide signals by root TGA transcription factors is essential for survival under fluctuating nitrogen environments
Authors: Kobayashi Ryutaro , Ohkubo Yuri , Izumi Mai , Ota Ryosuke , Yamada Keiko , Hayashi Yoko , Yamashita Yasuko , Noda Saki , Ogawa-Ohnishi Mari , Matsubayashi Yoshikatsu 
Published: October 2023

AbstractUnlike plants in the field, which experience significant temporal fluctuations in environmental conditions, plants in the laboratory are typically grown in controlled, stable environments. Therefore, signaling pathways evolved for survival in continuously fluctuating environments often remain functionally latent in laboratory settings. Here, we show that TGA1 and TGA4 act as hub transcription factors through which the expression of genes involved in high-affinity nitrate uptake are regulated in response to shoot-derived phloem mobile polypeptides, CEP DOWNSTREAM 1 (CEPD1), CEPD2 and CEPD-like 2 (CEPDL2) as nitrogen (N) deficiency signals, and Glutaredoxin S1 (GrxS1) to GrxS8 as N sufficiency signals. CEPD1/2/CEPDL2 and GrxS1-S8 competitively bind to TGA1/4 in roots, with the former acting as transcription coactivators that enhance the uptake of nitrate, while the latter function as corepressor complexes together with TOPLESS to limit nitrate uptake.Arabidopsisplants deficient in TGA1/4 maintain basal nitrate uptake and exhibit growth similar to wild-type plants in a stable N environment, but were impaired in regulation of nitrate acquisition in response to shoot N demand, leading to defective growth under continuously fluctuating N environments where rhizosphere nitrate ions switch periodically between deficient and sufficient states. TGA1/4 are crucial transcription factors that enable plants to survive under fluctuating and challenging N environmental conditions.
Grain chain management and development: evidence form Agri-SMEs in Kosovo
Authors: Totojani Anika , Ramadani Veland 
Published: October 2023

Purpose
This study aims to explore the grain chain in Kosovo. This study also aims to analyse the role of actors involved in the supply, production, processing, marketing and distribution of the grain value chain.

Design/methodology/approach
The study uses qualitative methods. A total of 60 semi-structured interviews are conducted with actors involved in the entire grain value chain.

Findings
Findings reveal that the country depends on grain imports and lacks an organised grain market, which is often distorted by the present political situation. Stakeholders are partly integrated in the grain value chain, and they are not very efficient in production. The existence of an informal market influences the decision-making of actors involved in the grain chain. The grain value chain displays mixed governance types, and the relationships among actors are based on the trust mechanism.

Originality/value
The research draws the importance of agriculture’s public policies to sustain domestic grain production. Public–private partnerships should be created to restore the grain market. Trading policies should be revised because they play a crucial role in enhancing fair competition between domestic and foreign traders.
Customer participation in manufacturing firms’ new service development: the moderating role of CRM technology
Authors: Morgan Todd , Friske Wesley , Kohtamäki Marko , Mills Paul 
Published: October 2023

PurposeThis paper aims to examine how customer participation in new service development (NSD) and customer relationship management (CRM) technology can improve the NSD performance of manufacturing firms. Additionally, the paper examines CRM technology usage to understand how it impacts new service performance both individually and jointly with customer participation in NSD.Design/methodology/approachThis study is a survey of 216 manufacturing managers who are overseeing the development of new services at their organizations. For the analysis, structural equation modeling is used with Amos 22.0. Measures of all latent variables in the analysis pass the traditional tests for reliability, convergent validity and discriminant validity. Furthermore, the results of a common latent factor test for common method variance and Harman’s one-factor test indicate that common method bias is not a source of endogeneity in the model.FindingsCustomer participation has a positive effect on NSD performance. CRM technology usage also has a positive effect on NSD performance. The effect of customer participation on NSD performance is enhanced by CRM technology. The results of a post hoc analysis suggest that the usage of CRM technology has the most benefit for managing the technical aspects of customer participation.Research limitations/implicationsThis study has methodological limitations that may impact the generalizability of results. For instance, it is based on cross-sectional self-reported survey data, which is more subjective than longitudinal secondary data. Survey research lacks the depth and nuance of qualitative research designs, which are commonly employed to study NSD. In addition, this study focuses on large US manufacturing firms. The authors do not include small firms or international organizations in the sample. Despite these limitations, they believe the findings can provide significant contributions to the NSD literature.Practical implicationsAlthough prior research has shown that customer participation and CRM technology can individually influence new product development (NPD) performance, the results indicate they are equally effective factors in the development of new services. Furthermore, the authors show that customer participation can be enhanced via the use of CRM technologies. The interaction is more pronounced within the technical aspects of NSD.Originality/valueThis study contributes to the NSD literature, and it also has implications for managers leading NSD efforts in traditional tangible-product industries. The findings provide additional evidence that customer participation is an effective NSD strategy for manufacturing firms (Morganet al., 2019). Furthermore, CRM technology is integral to NSD performance. CRM technology not only has a direct effect on NSD performance, but the interaction term of customer participation by CRM technology also has a positive effect on NSD performance.
The impact of institutional child abuse: views of professionals
Authors: Ozanne Rebecca , Ireland Jane L. , Ireland Carol A. , Thornton Abigail 
Published: October 2023

Purpose
The purpose of this study is to build on previous literature in this area thus, the views of professionals working with those who report institutional abuse was sought using a Delphi method.

Design/methodology/approach
Professionals working with those who report institutional abuse, such as psychologists, social workers and personal injury lawyers, were invited to engage in the Delphi study. Sixteen professionals completed the final round (with four rounds in total). This method was used to gain professional consensus on the considered impacts of institutional child abuse and what factors influence impacts.

Findings
Eight superordinate themes were developed, as follows: institutional abuse has lasting negative effects on well-being, functioning and behaviour; loss of trust in others and the system is a potential outcome of institutional abuse; negative impacts on future life chances; negative impacts of institutional abuse are exacerbated by numerous factors; protective factors reduced negative impacts; psychological intervention is useful for survivors; positive and negative impacts of disclosure – the response of others as important; and keep impacts individualised.

Practical implications
The need for an individualised approach when working with those reporting institutional abuse was a salient finding.

Originality/value
Institutional abuse is known to result in several negative impacts, although research into this area is limited with a need to better understand what may protect or exacerbate impacts.
How customer incivility affects organization citizenship behavior: roles of depersonalization, resilience, and caring climate
Authors: Lee Kangcheol , Gong Taeshik 
Published: October 2023

Purpose
Drawing on the conservation of resources theory, this study aims to identify the mediating effects of depersonalization and resilience on the relationship between customer incivility and organizational citizenship behavior (OCB). It further posits that these indirect effects vary depending on the caring climate and achievement orientation.

Design/methodology/approach
A field survey among 622 service employees (Study 1) and a three-wave field survey of 315 service employees and their managers (Study 2) from various service organizations were conducted.

Findings
This study confirms that depersonalization operates as a negative mediator in the relationship between customer incivility and OCB. Simultaneously, resilience emerges as a positive mediator, underscoring the contrasting pathways through which customer incivility affects OCB. Furthermore, a caring climate plays a pivotal role in mitigating the detrimental impact of depersonalization on OCB and weakening the positive impact of resilience on OCB. Additionally, this study identifies achievement orientation as a significant moderator between customer incivility and resilience.

Originality/value
This study advances theoretical foundations by investigating depersonalization and resilience as critical mediators in the intricate relationship between customer incivility and OCB. It goes beyond the conventional understanding of customer incivility’s impact by shedding light on the dual roles of a caring climate, demonstrating its potential to alleviate both positive and negative consequences of customer incivility. Moreover, its identification of achievement orientation as a moderator adds a novel dimension to the discourse, emphasizing the need for tailored strategies to harness employee resilience in the face of customer incivility.
Accurately and explicitly simulating distinct tensile and compressive behaviors of various concretes with new elastoplasticity model
Authors: Liu Quan-Pu , Kang Jia , Tan Long-Xu , Wang Si-Yu , Bruhns Otto , Xiao Heng 
Published: October 2023

PurposeThis paper aims to present a direct analysis to demonstrate why markedly different tensile and compressive behaviors of concretes could not be simulated with the Drucker–Prager yield criterion.Design/methodology/approachThis study proposed an extended form of the latter for establishing a new elastoplasticity model with evolving yield strengths.FindingsExplicit closed-form solutions to non-symmetric tensile and compressive responses of uniaxial specimens at finite strain are for the first time obtained from hardening to softening.Originality/valueWith such exact solutions, the yield strengths in tension and compression can be explicitly prescribed by uniaxial tensile and compressive stress-strain functions. Then, the latter two are further provided in explicit forms toward accurately simulating tensile and compressive behaviors. Numerical examples are supplied for meso-scale heterogeneous concrete (MSHC) and high-performance concrete (HPC), etc. Model predictions are in good agreement with test data.