bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profil Status Gizi Ibu Hamil dengan Luaran Bayi Berat Lahir Rendah di RS. Budi Kemuliaan
Authors: Sugihanawati Anah , Lavida Tiarlin 
Published: October 2023

Kondisi Berat Badan Lahir Rendah (BBLR) sebesar 34,5% di tahun 2021 menjadi penyebab utama kematian neonatal (bayi usia 0-28 hari). Faktor risiko terbanyak adalah aspek status gizi ibu hamil. Status gizi ibu hamil sangat bervariasi. Status gizi dari kondisi kekurangan energi kronik (KEK), indeks masa tubuh (IMT) yang kurang dari normal dan anemia defisiensi besi. Tujuan dari penelitian ini adalah untuk mendapatkan profil status gizi ibu hamil dengan luaran berat bayi lahir rendah.
Penelitian ini merupakan observasi deskriptif dengan metode potong lintang. Variabel status gizi berdasarkan status KEK (kekurangan energi kronik), IMT (Indeks Masa Tubuh) dan Anemia (Kadar Hb). Penelitian ini menggunakan data sekunder, dengan mengambil data dari rekam medik. Sampel penelitian ini adalah ibu bersalin usia kehamilan aterm dengan bayi berat lahir rendah (< 2500 gram) di RS Budi Kemuliaan Mei 2020, sebanyak 81 orang. Teknik pengambilan sampel dilakukan purposive sampling.
Hasil penelitian didapatkan 81 ibu yang melahirkan BBLR berasal dengan kondisi KEK saat hamil sebanyak 6 orang (7,4%). Ibu hamil dengan IMT kurang sebanyak 6 orang dan anemia ringan sebanyak 31 orang.
Pada penelitian ini didapatkan Profil ibu hamil dengan luaran bayi BBLR didapatkan status gizi ibu dengan anemia paling dominan (37 orang). Status IMT kurang dan ibu dengan KEK sebanyak 6 orang (7,4%). Status gizi ibu hamil dengan KEK, IMT di bawah normal dan ibu dengan anemia defisiensi besi dapat dijadikan fokus pada asuhan kebidanan yang akan diberikan. Pemantauan ketat pada tumbuh kembang janin, pola makan ibu, penambahan berat badan ibu saat kunjungan ANC.
Parental attitudes to the problem of home-based education of children with disabilities
Authors: Brutskaia Kseniia 
Published: October 2023

The purpose of the study: to identify and study parental attitudes to the problem of home-based education of children with disabilities. Research methods: questionnaire "Assessment of coping strategies in various fields" (E. Heim); "Questionnaire for parents whose children are home-schooled". The developed questionnaire includes 13 questions. The questions are aimed at identifying the difficulties and needs of parents in organizing home-based education. The main method of the study was the content analysis of the respondents' free statements, which presupposes the completion of a number of sentences. Meaningful interpretation of the highlighted answers allows you to identify hidden semantic experiences, difficulties, as well as to outline optimal ways to solve problems. The study involved 60 parents with children with disabilities (school age) who are on home-based education. According to the results of the content analysis of the parents' statements, 85 completed semantic units were identified, which, according to the psychological content, were combined into semantic categories reflecting the difficulties of parents in the home-based form of teaching a child with disabilities: "learning and upbringing difficulties", "psychological and pedagogical difficulties", "medical difficulties". The results of the study showed that parents whose children are home-schooled can be differentiated depending on the duration of the child's education at home.
Contact-independent exposure to Rhodococcus rhodochrous DAP96253 volatiles does not improve the survival rate of Myotis lucifugus (little brown bats) affected by White-nose Syndrome
Authors: Hooper Sarah , Amelon Sybill 
Published: October 2023

Since the emergence of White-nose Syndrome, a fungal disease in bats, caused by Pseudogymnoascus destructans, hibernating populations of little brown bats (Myotis lucifugus) have declined by 70–90% within P. destructans positive hibernacula. To reduce the impact of White-nose Syndrome to North American little brown bat populations we evaluated if exposure to volatile organic compounds produced by induced cells from Rhodococcus rhodochrous strain DAP96253 could improve the overwinter survival of bats infected by P. destructans. Two simultaneous field treatment trials were conducted at natural hibernacula located in Rockcastle and Breckinridge counties, Kentucky, USA. A combined total of 120 little brown bats were randomly divided into control groups (n = 60) which were not exposed to volatile organic compounds and treatment groups (n = 60) which were exposed to volatile organic compounds produced by non-growth, fermented cell paste composed of R. rhodochrous strain DAP96253 cells. Cox proportional hazard models revealed a significant decreased survival at the Rockcastle field trial site but not the Breckinridge field site. At the Breckinridge hibernacula, overwinter survival for both treatment and control groups were 60%. At the Rockcastle hibernacula, Kaplan-Meier survival curves indicated significantly increased overwinter survival of bats in the control group (43% survived) compared to the treatment group (20% survived). Although complete inhibition of P. destructans by volatile organic compounds produced by induced R. rhodochrous strain DAP96253 cells was observed in vitro studies, our results suggest that these volatile organic compounds do not inhibit P. destructans in situ and may promote P. destructans growth.
AI‐Driven Wearable Mask‐Inspired Self‐Healing Sensor Array for Detection and Identification of Volatile Organic Compounds
Authors: Chen Mingrui , Zhang Min , Yang Ziyang , Zhou Cheng , Cui Daxiang , Haick Hossam , Tang Ning 
Published: October 2023

AbstractVolatile organic compounds (VOCs) sensor arrays have garnered considerable attention due to their potential to provide real‐time information for monitoring pollution levels and personal health associated concerning VOCs in the ambient environment. Here, an AI‐driven wearable mask‐inspired self‐healing sensor array (MISSA), created using a simplified single‐step stacking technique for detecting and identifying VOCs is presented. This wearable MISSA comprises three vertically placed breathable self‐healing gas sensors (BSGS) with linear response behavior, consistent repeatability, and reliable self‐healing abilities. For wearable and portable monitoring, the MISSA is combined with a flexible printed circuit board (FPCB) to produce a mobile‐compatible wireless system. Due to the distinct layers of MISSA, it creates exclusive code bars for four distinct VOCs over three concentration levels. This grants precise gas identification and concentration prognoses with excellent accuracy of 99.77% and 98.3%, respectively. The combination of MISSA with artificial intelligence (AI) suggests its potential as a successful wearable device for long‐term daily VOC monitoring and assessment for personal health monitoring scenarios.
Selective Immunosuppression Targeting the NLRP3 Inflammasome Mitigates the Foreign Body Response to Implanted Biomaterials While Preserving Angiogenesis
Authors: Chan Alex H.P. , Moore Matthew J. , Grant Angus J. , Lam Yuen Ting Monica , Darnell Matthew V. , Michael Praveesuda L. , Wise Steven G. , Tan Richard P. 
Published: October 2023

AbstractMedical devices are a mainstay of the healthcare industry, providing clinicians with innovative tools to diagnose, monitor, and treat a range of medical conditions. For implantable devices, it is widely regarded that chronic inflammation during the foreign body response (FBR) is detrimental to device performance, but also required for tissue regeneration and host integration. Current strategies to mitigate the FBR rely on broad acting anti‐inflammatory drugs, most commonly, dexamethasone (DEX), which can inhibit angiogenesis and compromise long‐term device function. This study challenges prevailing assumptions by suggesting that FBR inflammation is multifaceted, and selectively targeting its individual pathways can stop implant fibrosis while preserving beneficial repair pathways linked to improved device performance. MCC950, an anti‐inflammatory drug that selectively inhibits the NLRP3 inflammasome, targets pathological inflammation without compromising global immune function. The effects of MCC950 and DEX on the FBR are compared using implanted polycaprolactone (PCL) scaffolds. The results demonstrate that both DEX and MCC950 halt immune cell recruitment and cytokine release, leading to reduced FBR. However, MCC950 achieves this while supporting capillary growth and enhancing tissue angiogenesis. These findings support selective immunosuppression approaches as a potential future direction for treating the FBR and enhancing the longevity and safety of implantable devices.
PLD Epitaxial Thin‐Film BaTiO3 on MgO − Dielectric and Electro‐Optic Properties
Authors: Winiger Joel , Keller Killian , Moor David , Baumann Michael , Kim Donghoon , Chelladurai Daniel , Kohli Manuel , Blatter Tobias , Dénervaud Eric , Fedoryshyn Yuriy , Koch Ueli , Pané Salvador , Grange Rachel , Leuthold Juerg 
Published: October 2023

AbstractThe study demonstrates high‐quality pulsed‐laser‐deposited (PLD) barium titanate (BTO) thin‐films on a magnesium oxide substrate. The frequency response of the relative permittivity (dielectric constant) and the linear electro‐optical coefficient (Pockels coefficient) are measured. At 0.2 GHz, the Pockels coefficient is fitted to be r42 ≈ 1030 pm V−1. It decreases to ≈390 pm V−1 at 10 GHz after which it remains constant up to 70 GHz. The unbiased BTO permittivity is measured to be εa ≈ 7600 at 0.2 GHz, dropping to ≈1100 at 67 GHz, while the biased BTO had a permittivity εa ≈ 2000 at 0.2 GHz, dropping to ≈500 at 67 GHz. These results fill an important experimental characterization gap for high‐speed BTO applications and show the high quality of PLD‐grown BTO films. Lastly, the material's crystalline quality is characterized and the domain distribution is imaged. The findings enable the design and fabrication of a new generation of BTO‐based components for sensing and communications.
Wirelessly Powered Sensing Fertilizer for Precision and Sustainable Agriculture
Authors: Kasuga Takaaki , Mizui Ami , Koga Hirotaka , Nogi Masaya 
Published: October 2023

AbstractSensor networks comprising small wireless sensor devices facilitate the collection of environmental information and increase the efficiency of outdoor practices, including agriculture. However, the sensor‐device installation density of a network is limited because conventional sensor devices must be removed after use. In this study, a sustainable dense sensing system that combines simplified degradable sensor devices, wireless power supply, and thermal‐camera image‐based information recognition is proposed. The proposed wireless‐power‐driven sensor device comprises a biodegradable nanopaper substrate, natural wax, and an eco‐friendly tin conductive line. The sensor device emits a thermal signal based on the soil moisture content. The thermal camera simultaneously acquires the soil moisture‐content data and sensor‐device location. The majority of the sensor‐device components are biodegradable, and the residual components have a minimal adverse impact on the environment. Additionally, the fertilizer component in the substrate promotes plant growth. The proposed sensing concept introduces a novel direction for realizing hyperdense sensor networks and contributes to the development of social systems that combine sustainability with meticulous environmental management.
Multifunctional Oxidized Dextran–Metformin as a Tissue‐Adhesive Hydrogel to Prevent Postoperative Peritoneal Adhesions in Patients with Metabolic Syndrome
Authors: Liu Xi , Song Xianwen , Zhang Zequn , Yang Shutong , Li Liang , Lin Changwei , Chen Miao , Liu Chuntai , Li Xiaorong , Zhang Yi , Hu Gui 
Published: October 2023

AbstractPatients with metabolic syndrome (MetS) undergoing surgery are at high risk of developing peritoneal adhesions and other severe postoperative complications. However, the single shielding function and absence of physiological activity render conventional methods less useful in preventing adhesions in patients with MetS. To address this challenge, a convenient method is introduced for developing a novel tissue‐adhesive hydrogel called oxidized dextran–metformin (ODE–ME) via Schiff base linkages. This injectable ODE–ME hydrogel exhibits excellent tissue‐adhesive properties and various physiological functions, particularly enhanced antibacterial effects. Furthermore, in vivo experiments demonstrate that the hydrogel can effectively alleviate hyperglycemia, reduce excessive inflammation, and improve fibrinolytic activity in MetS mice, thereby preventing adhesions and promoting incisional healing. The hydrogel concurrently isolates injured tissues and lowers the blood glucose levels immediately after surgery in mice. Therefore, the ODE–ME hydrogel functions as a multifunctional barrier material and has potential for preventing postoperative peritoneal adhesions in patients with MetS in clinical settings.
Low Operating Voltage and Immediate Read‐After‐Write of HZO‐Based Si Ferroelectric Field‐Effect Transistors with High Endurance and Retention Characteristics
Authors: Kim Bong Ho , Kuk Song‐Hyeon , Kim Seong Kwang , Kim Joon Pyo , Suh Yoon‐Je , Jeong Jaeyong , Lee Chan Jik , Geum Dae‐Myeong , Yoon Young Joon , Kim Sang Hyeon 
Published: October 2023

AbstractThe study demonstrates HfZrOx (HZO)‐based Si ferroelectric field‐effect transistors (FeFETs) with a low operating voltage (1.5 V) and immediate read‐after‐write operation (100 ns) via HZO thickness scaling, electron‐beam‐irradiation (EBI) treatment, and interfacial layer (IL) scavenging. With these three strategies, reduced operating voltage, immediate read‐after‐write capability, and improved endurance (>108 cycles) and retention (extrapolated 10‐year) characteristics are achieved in FeFETs. The improved characteristics of FeFETs are attributed to the reduced operating voltage by HZO thickness scaling, the ferroelectric orthorhombic phase‐oriented crystallization by EBI treatment, and the reduced gate voltage drop across the IL and reduced depolarization field by the IL scavenging. It is believed that this work contributes to the development of low‐power and fast‐read FeFETs.
A mesomelic skeletal dysplasia, Kantaputra‐like, not related to HOXD cluster region, and with phenotypic gender differences
Authors: Lacarrubba‐Flores Maria Dora Jazmin , da Costa Silveira Karina , Silveira Cynthia , Carvalho Benilton S. , Cavalcanti Denise Pontes 
Published: October 2023

AbstractMesomelic skeletal dysplasia is a heterogeneous group of skeletal disorders that has grown since the molecular basis of these conditions is in the process of research and discovery. Here, we report a Brazilian family with eight affected members over three generations with a phenotype similar to mesomelic Kantaputra dysplasia. This family presents marked shortening of the upper limbs with hypotrophy of the lower limbs and clubfeet without synostosis. Array‐based CNV analysis and exome sequencing of four family members failed to show any region or gene candidate. Interestingly, males were more severely affected than females in this family, suggesting that gender differences could play a role in the phenotypic expressivity of this condition.
Organocatalytic Dynamic Kinetic Resolution Enabled Asymmetric Synthesis of Phosphorus‐Containing Chiral Helicenes
Authors: Wu Jia‐Hong , Fang Siqiang , Zheng Xingtao , He Jiajia , Ma Yi , Su Zhishan , Wang Tianli 
Published: October 2023

AbstractThe catalytic asymmetric synthesis of phosphorus‐containing helicenes remains a formidable challenge, presumably due to the lack of rational design of substrates, right choice of reactions together with highly effective catalysis systems. Herein, we disclosed an efficient and practical DKR‐involving (dynamic kinetic resolution) cascade strategy toward synthesizing a novel family of phosphorus‐installing helicenes by peptide‐mimic phosphonium salt (PPS) catalysis. The sequential process of PPS‐catalyzed phospha‐Michael attack and copper salt‐facilitated aromatization led to the formation of unprecedented phosphorus‐containing oxa[5]helicene scaffolds. A wide variety of substrates bearing an assortment of functional groups were compatible with this protocol, furnishing the expected helical compounds in high yields and excellent stereoselectivities. Additionally, the helical products could be conveniently elaborated to promising phosphine ligands with perfectly retained helical chirality, which turned out to be highly efficient chiral ligands in transition metal‐catalyzed reactions. These findings not only expand the current library of phosphorus‐containing helicenes but also offer insights to explore other challenging scaffolds with molecular chirality.
Synthetic High‐Density Lipoprotein‐Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma
Authors: Yang Chunrong , Li Yujie , Yang Yuchen , Ni Qiankun , Zhang Zeyu , Chai Yi , Li Jinghong 
Published: October 2023

AbstractImmunotherapies have shed light on the treatment of many cancers, but have not improved the outcomes of glioma (GBM). Here, we demonstrated that suppressor of cytokine signaling 1 (SOCS1) was associated with the GBM‐associated immunosuppression and developed a multifunctional nanomedicine, which silenced SOCS1 in the tumor microenvironment (TME) of GBM and triggered strong antitumor immunity against GBM. Synthetic high‐density lipoprotein (sHDL) was selected as the nanocarrier and a peptide was used to facilitate the blood‐brain‐barrier (BBB) penetration. The nanocarrier was loaded with a small interfering RNA (siRNA), a peptide, and an adjuvant to trigger antitumor immunity. The nanomedicine concentrated on the TME in vivo, further promoting dendritic cell maturation and T cell proliferation, triggering strong cytotoxic T lymphocyte responses, and inhibiting tumor growth. Our work provides an alternative strategy to simultaneously target and modulate the TME in GBM patients and points to an avenue for enhancing the efficacy of immunotherapeutics.
Intermolecular Carbophosphination of Alkynes with Phosphole Oxides via Ni−Al Bimetal‐Catalyzed C−P Bond Activation
Authors: Zhang Feng‐Ping , Wang Rong‐Hua , Li Jiang‐Fei , Chen Hao , Hari Babu Madala , Ye Mengchun 
Published: October 2023

AbstractIntermolecular carbophosphination reaction of alkynes or alkenes with unreactive C−P bonds remains an elusive challenge. Herein, we used a Ni−Al bimetallic catalyst to realize an intermolecular carbophosphination reaction of alkynes with 5‐membered phosphole oxides, providing a series of 7‐membered phosphepines in up to 94 % yield.
Development of a continuous fermentation process for the production of recombinant uricase enzyme by Pichia pastoris
Authors: Mahboudi Sanaz , Abbas Shojaosadati Seyed , Maghsoudi Amir , Mahmoudi Behrouz 
Published: October 2023

AbstractRecent studies in the biopharmaceutical industry have shown an increase in the productivity and production efficiency of recombinant proteins by continuous culture. In this research, a new upstream fermentation process was developed for the production of recombinant uricase in the methylotrophic yeast Pichia pastoris. Expression of recombinant protein in this system is under the control of the AOX1 promoter and therefore requires methanol as an inducing agent and carbon/energy source. Considering the biphasic growth characteristics of conventional fed‐batch fermentation, physical separation of the growth and induction stages for better control of the continuous fermentation process resulted in higher dry‐cell weight (DCW) and enhanced recombinant urate oxidase activity. The DCW and recombinant uricase activity enzyme for fed‐batch fermentation were 79 g/L and 6.8 u/mL. During the continuous process, in the growth fermenter at a constant dilution rate of 0.025 h−1, DCW increased to 88.39 g/L. In the induction fermenter, at methanol feeding rates of 30, 60, and 80 mL/h, a recombinant uricase activity was 4.13, 7.2, and 0 u/mL, respectively. The optimum methanol feeding regime in continuous fermentation resulted in a 4.5‐fold improvement in productivity compared with fed‐batch fermentation from 0.04 u/mL/h (0.0017 mg/mL/h) to 0.18 u/mL/h (0.0078 mg/mL/h).
Applying means‐end chains theory to understanding psychological cognitive structure of online video sharing platforms: A study of user behavior in TikTok
Authors: Lin Hong‐Wen 
Published: October 2023

AbstractThe means‐end chains theory was used in this study to explore the attributes most valued by TikTok users and to examine the resulting psychological values generated. Laddering interviews were used for content analysis and “online video sharing platform attributes—user consequences—personal values” psychological cognitive structures, from a perspective of the user were constructed using the structural implication matrix and hierarchical value map. A total of 34 elements were identified from the results of the study. The categorization of attribute elements was also expanded to include motivation for social media communication and interaction, which have not been previously explored. The results showed that diverse video genre, interesting video content, easy‐to‐use interface, visual effects application, and community sharing and recommendation are key platform attributes valued by users. The facilitating observational learning, promoting the joy of life, raising convenience, having fun with friends, relieving emotional stress, and other user consequences were generated by platform attributes. And lastly, personal values such as a sense of accomplishment, fun and enjoyment of life, warm relationships with others, and sense of belonging were gained. In addition, the study also finds that there are differences in the psychological cognitive structures between genders and that the correlations and influences among the elements have different degrees of significance. These findings can give marketers and policymakers a better understanding of the behavior of TikTok users and help them develop better strategies for marketing and promotion of the platform.
Take a break! Leisure participation moderates the workaholism–work stress relationship
Authors: Aziz Shahnaz , Meier Brittany , Wuensch Karl , Dolbier Christyn 
Published: October 2023

AbstractOur primary aim was to gain a better understanding of how leisure activities (i.e., physical activity, mindfulness, and vacation) may beneficially relate to workaholism and work stress. Secondary aims included exploring motivations for participating in the three types of leisure activities. The job demands‐resources theory; conservation of resources theory; and detachment‐recovery, autonomy, mastery, meaning, and affiliation model provided context for hypothesized relationships among the variables. Full‐time employees in the United States (N = 367) were recruited via Amazon's Mechanical Turk community, and they completed an online survey. Leisure participation significantly moderated the relationship between workaholism and work stress (weakening it). The majority of motivations for mindfulness and vacation were related to mental/emotional health, with a more even split between mental/emotional health and physical health/appearance motivations for physical activities. Several policy and practice‐based recommendations for prioritizing leisure engagement are provided.