bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnitude of meconium stained amniotic fluid and associated factors among women who gave birth in North Shoa Zone hospitals, Amhara Region, Ethiopia 2022
Authors: Tefera Mitiku , Birhanu Dagmawit , Mihretie Abebe , Belete Ewunetu , Demis Abrham , Alemaw Leweyehu 
Published: February 2024

Background
The presence of meconium-stained amniotic fluid is one of the causes for birth asphyxia. Each year, over five million neonatal deaths occur worldwide because of meconium-stained amniotic fluid and other causes, of which 90% are due to birth asphyxia. The aim of this study was to assess the magnitude of meconium-stained amniotic fluid and associated factors among women who gave birth in North Shoa Zone Hospitals, Amhara Region, Ethiopia, 2022.

Materials and methods
An institutional-based cross-sectional study was employed. We used 610 women who gave birth at North Shoa Zone Hospitals, Amhara region, Ethiopia. The study was conducted from June 8 to August 8, 2022. Recruitment for the study was made using a multistage sampling procedure. Fifty percent of the study hospitals were randomly selected, and proportional allocation was done. Participants were selected from the sampling frame, labour and delivery register book, using a systematic random sampling approach. The first person was selected at random, while the remaining individuals were selected at every two "K" intervals across all hospitals. An interview-administered structured questionnaire and chart review checklist were used to gather the data that were entered into Epi-Data Version 4.6 and exported to SPSS. Logistics regression was employed, and a p-value <0.05 was considered statistically significant.

Result
The magnitude of meconium-stained amniotic fluid was 30.3%. Women with a normal hematocrit level were 83% less likely to develop meconium-stained amniotic fluid. Women whose mid-upper arm circumference value was less than 22.9cm (AOR = 1.9; 95% CI: 1.18–3.20), obstructed labour (AOR = 3.6; 95% CI: 1.48–8.83), prolonged labour ≥ 15 hr (AOR = 7.5; 95% CI: 7.68–13.3), premature rapture of membrane (AOR = 1.7; 95% CI: 3.22–7.40), foetal tachycardia (AOR = 6.2; 95% CI: 2.41–16.3), and Bradycardia (AOR = 3.1; 95% CI: 1.93–5.28) showed a significant association with meconium-stained amniotic fluid.

Conclusion
The present study revealed that the magnitude of meconium-stained amniotic fluid in North Shoa Zone is nearly one-third. A normal hematocrit level is a preventive factor for meconium-stained amniotic fluid, and a MUAC value <22.9 cm, obstructed and prolonged labour, PROM, bradycardia, and tachycardia are factors associated with meconium-stained amniotic fluid.
Can ChatGPT assist authors with abstract writing in medical journals? Evaluating the quality of scientific abstracts generated by ChatGPT and original abstracts
Authors: Hwang Taesoon , Aggarwal Nishant , Khan Pir Zarak , Roberts Thomas , Mahmood Amir , Griffiths Madlen M. , Parsons Nick , Khan Saboor 
Published: February 2024

Introduction
ChatGPT, a sophisticated large language model (LLM), has garnered widespread attention for its ability to mimic human-like communication. As recent studies indicate a potential supportive role of ChatGPT in academic writing, we assessed the LLM’s capacity to generate accurate and comprehensive scientific abstracts from published Randomised Controlled Trial (RCT) data, focusing on the adherence to the Consolidated Standards of Reporting Trials for Abstracts (CONSORT-A) statement, in comparison to the original authors’ abstracts.

Methodology
RCTs, identified in a PubMed/MEDLINE search post-September 2021 across various medical disciplines, were subjected to abstract generation via ChatGPT versions 3.5 and 4, following the guidelines of the respective journals. The overall quality score (OQS) of each abstract was determined by the total number of adequately reported components from the 18-item CONSORT-A checklist. Additional outcome measures included percent adherence to each CONOSORT-A item, readability, hallucination rate, and regression analysis of reporting quality determinants.

Results
Original abstracts achieved a mean OQS of 11.89 (95% CI: 11.23–12.54), outperforming GPT 3.5 (7.89; 95% CI: 7.32–8.46) and GPT 4 (5.18; 95% CI: 4.64–5.71). Compared to GPT 3.5 and 4 outputs, original abstracts were more adherent with 10 and 14 CONSORT-A items, respectively. In blind assessments, GPT 3.5-generated abstracts were deemed most readable in 62.22% of cases which was significantly greater than the original (31.11%; P = 0.003) and GPT 4-generated (6.67%; P<0.001) abstracts. Moreover, ChatGPT 3.5 exhibited a hallucination rate of 0.03 items per abstract compared to 1.13 by GPT 4. No determinants for improved reporting quality were identified for GPT-generated abstracts.

Conclusions
While ChatGPT could generate more readable abstracts, their overall quality was inferior to the original abstracts. Yet, its proficiency to concisely relay key information with minimal error holds promise for medical research and warrants further investigations to fully ascertain the LLM’s applicability in this domain.
A scoping review of the unmet needs of patients diagnosed with idiopathic pulmonary fibrosis (IPF)
Authors: Bramhill Carita , Langan Donna , Mulryan Helen , Eustace-Cook Jessica , Russell Anne-Marie , Brady Anne-Marie 
Published: February 2024

Aims
Patients diagnosed with idiopathic pulmonary fibrosis (IPF) have a high symptom burden and numerous needs that remain largely unaddressed despite advances in available treatment options. There is a need to comprehensively identify patients’ needs and create opportunities to address them. This scoping review aimed to synthesise the available evidence and identify gaps in the literature regarding the unmet needs of patients diagnosed with IPF.

Methods
The protocol for the review was registered with Open Science Framework (DOI 10.17605/OSF.IO/SY4KM). A systematic search was performed in March 2022, in CINAHL, MEDLINE, Embase, PsychInfo, Web of Science Core Collection and ASSIA Applied Social Science Index. A comprehensive review of grey literature was also completed. Inclusion criteria included patients diagnosed with IPF and date range 2011–2022. A range of review types were included. Data was extracted using a data extraction form. Data was analysed using descriptive and thematic analysis. A total of 884 citations were reviewed. Ethical approval was not required.

Results
52 citations were selected for final inclusion. Five themes were identified: 1.) psychological impact of an IPF diagnosis. 2.) adequate information and education: at the right time and in the right way. 3.) high symptom burden support needs. 4.) referral to palliative care and advance care planning (ACP). 5.) health service provision-a systems approach.

Conclusion
This review highlights the myriad of needs patients with IPF have and highlights the urgent need for a systems approach to care, underpinned by an appropriately resourced multi-disciplinary team. The range of needs experienced by patients with IPF are broad and varied and require a holistic approach to care including targeted research, coupled with the continuing development of patient-focused services and establishment of clinical care programmes.
Un thymiaterion cerámico de la necrópolis ibérica de Alarcos III (Poblete, Ciudad Real): el perfume y su uso ritual en el ámbito oretano
Authors: Rodríguez-Rabadán Díaz-Cano Miguel Ángel , Miguel-Naranjo Pedro 
Published: February 2024

En este trabajo abordamos de manera monográfica el contexto arqueológico de la tumba 45 de la necrópolis ibérica III de Alarcos, actualmente en proceso de excavación y de estudio. La tumba, adscrita a un individuo adulto posiblemente masculino, presenta como parte del ajuar un thymiaterion cerámico inédito compuesto por dos piezas: un soporte calado en su parte inferior y una cazoleta con asa y base perforada. Los paralelos formales que presenta con diferentes soportes calados del oppidum oretano del Cerro de las Cabezas (Valdepeñas, Ciudad Real) y la relación que mantiene la tumba 45 con otros contextos funerarios cercanos permiten datar la tumba entre los siglos IV y III a. C. En este estudio rastreamos los diferentes paralelos de las dos piezas que componen el thymiaterion cerámico en el contexto de la Oretania, así como los thymiateria de bronce y los pebeteros de terracota, y contrastamos si pueden clasificarse o no como posibles quemadores de perfumes. Por otro lado, analizamos el registro arqueológico de los yacimientos oretanos para documentar el empleo del perfume en la zona de estudio, analizando las diferentes tipologías de ungüentarios cerámicos, pasta vítrea y fayenza. Así, hemos podido atestiguar que, desde el siglo VI a. C. hasta época iberorromana, en la mayor parte de los casos el perfume aparece asociado a un uso cultual o funerario del mismo. Finalmente, un análisis detallado del registro material permite relacionar la combustión y el uso de aceites perfumados con el culto a una divinidad femenina relacionada con la fertilidad, la abundancia y la regeneración del ciclo vital.
Predicting Risk of Colorectal Cancer After Adenoma Removal in a Large Community-Based Setting
Authors: Lee Jeffrey K. , Jensen Christopher D. , Udaltsova Natalia , Zheng Yingye , Levin Theodore R. , Chubak Jessica , Kamineni Aruna , Halm Ethan A. , Skinner Celette S. , Schottinger Joanne E. , Ghai Nirupa R. , Burnett-Hartman Andrea , Issaka Rachel , Corley Douglas A. 
Published: February 2024

INTRODUCTION:
Colonoscopy surveillance guidelines categorize individuals as high or low risk for future colorectal cancer (CRC) based primarily on their prior polyp characteristics, but this approach is imprecise, and consideration of other risk factors may improve postpolypectomy risk stratification.

METHODS:
Among patients who underwent a baseline colonoscopy with removal of a conventional adenoma in 2004–2016, we compared the performance for postpolypectomy CRC risk prediction (through 2020) of a comprehensive model featuring patient age, diabetes diagnosis, and baseline colonoscopy indication and prior polyp findings (i.e., adenoma with advanced histology, polyp size ≥10 mm, and sessile serrated adenoma or traditional serrated adenoma) with a polyp model featuring only polyp findings. Models were developed using Cox regression. Performance was assessed using area under the receiver operating characteristic curve (AUC) and calibration by the Hosmer-Lemeshow goodness-of-fit test.

RESULTS:
Among 95,001 patients randomly divided 70:30 into model development (n = 66,500) and internal validation cohorts (n = 28,501), 495 CRC were subsequently diagnosed; 354 in the development cohort and 141 in the validation cohort. Models demonstrated adequate calibration, and the comprehensive model demonstrated superior predictive performance to the polyp model in the development cohort (AUC 0.71, 95% confidence interval [CI] 0.68–0.74 vs AUC 0.61, 95% CI 0.58–0.64, respectively) and validation cohort (AUC 0.70, 95% CI 0.65–0.75 vs AUC 0.62, 95% CI 0.57–0.67, respectively).

DISCUSSION:
A comprehensive CRC risk prediction model featuring patient age, diabetes diagnosis, and baseline colonoscopy indication and polyp findings was more accurate at predicting postpolypectomy CRC diagnosis than a model based on polyp findings alone.
Psychologische Sicherheit und ihre Bedeutung für eine gesunde Fehlerkultur
Authors: Queckbörner Boris 
Published: February 2024

Zusammenfassung
Der Beitrag stellt in aller Kürze das Konzept der psychologischen Sicherheit vor, wie es v. a. von Amy C. Edmondson ausgearbeitet worden ist. Mit Edmondson wird argumentiert, dass psychologische Sicherheit eindeutig positive und nachhaltige Auswirkungen auf die Organisationskultur entfaltet. So werden Mitarbeiter*innen in einer psychologisch sicheren Organisation angehalten, sich aktiv in die Gestaltung der Arbeitsprozesse einzubringen, um dadurch v. a. die sog. „Epidemie des Schweigens“ zu bekämpfen. In der Praxis gelingt dies primär dadurch, dass eine Entstigmatisierung von Fehlern und Scheitern stattfindet. Anstatt eine Kultur der Schuldzuweisung zu fördern, nehmen psychologisch sichere Organisationen Fehler und Scheitern als Chancen für organisationale Lernerfahrungen wahr. In der Folge entsteht eine positive Fehlerkultur, die am Ende zur kontinuierlichen Weiterentwicklung der Organisation und ihrer Mitarbeiter*innen beiträgt.
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays
Authors: Fazeli Badrieh , Gómez de San José Nerea , Jesse Sarah , Senel Makbule , Oeckl Patrick , Erhart Deborah K. , Ludolph Albert C. , Otto Markus , Halbgebauer Steffen , Tumani Hayrettin 
Published: February 2024

Abstract

Objectives
Increased levels of glial fibrillary acidic protein (GFAP) in blood have been identified as a valuable biomarker for some neurological disorders, such as Alzheimer’s disease and multiple sclerosis. However, most blood GFAP quantifications so far were performed using the same bead-based assay, and to date a routine clinical application is lacking.

Methods
In this study, we validated a novel second-generation (2nd gen) Ella assay to quantify serum GFAP. Furthermore, we compared its performance with a bead-based single molecule array (Simoa) and a homemade GFAP assay in a clinical cohort of neurological diseases, including 210 patients.

Results
Validation experiments resulted in an intra-assay variation of 10 %, an inter-assay of 12 %, a limit of detection of 0.9 pg/mL, a lower limit of quantification of 2.8 pg/mL, and less than 20 % variation in serum samples exposed to up to five freeze-thaw cycles, 120 h at 4 °C and room temperature. Measurement of the clinical cohort using all assays revealed the same pattern of GFAP distribution in the different diagnostic groups. Moreover, we observed a strong correlation between the 2nd gen Ella and Simoa (r=0.91 (95 % CI: 0.88–0.93), p<0.0001) and the homemade immunoassay (r=0.77 (95 % CI: 0.70–0.82), p<0.0001).

Conclusions
Our results demonstrate a high reliability, precision and reproducibility of the 2nd gen Ella assay. Although a higher assay sensitivity for Simoa was observed, the new microfluidic assay might have the potential to be used for GFAP analysis in daily clinical workups due to its robustness and ease of use.
Dopamine functionalized coatings for corrosion protection of metallic implants and advanced drug delivery: a review
Authors: Talha Mohd 
Published: February 2024

Abstract
The surface treatment of metallic implants is significant for their in-vivo performance. Biocompatible coatings play a crucial role in corrosion protection and other practical uses of biomedical devices to evade surgery failure and enhance their functions. Polydopamine (PDA), a mussel-inspired synthetic polymer, exhibits high potential as an adhesive middle layer to enhance the bonding at the interface between the metal substrate and coating materials and used for corrosion protection of the implants. Owing to its excellent biocompatibility along with unique drug loading perspective, several PDA-modified nanoparticles have also been preferred as drug carriers. This featured article is dedicated to summarizing the significance of PDA as a coating material for clinical applications. It was begun by describing the polymerization process of dopamine and then describes the PDA as an effective coating material for corrosion protection of implants with proposed mechanism. The beneficial effects of PDA containing coatings on corrosion protection of implants were also discussed. Next, was focused on PDA-modified nanostructures and emphasized the biocompatibility of PDA. The latest developments of PDA modified coatings/nanoparticles in advanced drug delivery applications were also discussed.
On the asymptotics of eigenvalues for a Sturm-Liouville problem with symmetric single-well potential
Authors: Başkaya Elif 
Published: February 2024

Abstract
In this article, Sturm-Liouville problem with one boundary condition including an eigenparameter is considered, and the asymptotic expansion of its eigenparameter is calculated. The problem also has a symmetric single-well potential, which is an important function in quantum mechanics.
Permittito aperiat oculum: typological considerations on P-lability and its interaction with morphosyntactic alignment in Latin medical texts
Authors: Ongenae Tim A.F. 
Published: February 2024

Abstract
This paper explores the diachrony of Latin P-labile verbs (verbs that can be used transitively and intransitively with the preservation of the Patient and without a formal change), availing itself from evidence in medical and veterinary texts from the first to seventh century AD. The first part of the analysis discusses the influence of verbal semantics on the domain of lability in these texts and how lability developed as a diathetic strategy for the anticausative, the causative and the passive in Latin. Special attention is paid to the increase of P-lability as an anticausative strategy and its relation to the mediopassive and reflexive anticausative strategies in Late Latin. The second part of the analysis proposes a new explanation for the increase of P-lability in Latin and discusses the consequences of the development of a semantic-based alignment in Late Latin (the extended accusative) on the syntax and development of P-labile verbs.
High gain and high-efficiency compact resonator antennas based on spoof surface plasmon polaritons
Authors: Tian Dou , Kianinejad Amin , Wang Jiafu , Guo Chen , Zhang Anxue 
Published: February 2024

Abstract
We proposed a high gain high-efficiency compact metallic resonator antenna operating at even-mode meander line spoof surface plasmon polaritons (MLSSPPs). The high radiation efficiency is caused by the bulk of fields crowded in lossless air near the antenna rather than in lossy dielectric as in conventional dielectric resonator antennas (DRAs). The proposed antenna also exhibits compact size because of its high effective refractive index. A reliable equivalent circuit model is proposed for the design of the resonator antenna with basic mode of half wavelength resonant mode. As an example, a meander-line SSPP antenna is designed, fabricated and measured. Both the simulated and measured results show the advantages of high efficiency and compact volume. In addition, the antenna achieves higher gain and wider relative bandwidth per wavelength cube volume compared with its counterparts. This method provides a good alternative for designing DRAs.
Quantitative impact assessment of transmission congestion and demand side management on electricity producers’ market power
Authors: Mittal Anupam , Singh Kanwardeep 
Published: February 2024

Abstract
This paper presents the impact of transmission congestion and demand side management on Electricity Producers’ market power using the quantitative investigation of pool-based market clearing mechanism. The mathematical problem formulation for pool-based market clearing consists of maximization of social welfare objective function, which incorporates maximization of demand benefit obtained from flexible demand bids and minimization of Electricity Producers’ real and reactive power costs obtained from actual and strategic supply bids. In this problem formulation, the nonlinear modeling of power system is used for real and reactive power flow equality constraints, transmission line capability inequality constraints (for incorporating the impact of transmission congestion), and generator capability curve equality constraints. The impacts of demand side management have been incorporated in the problem by considering single-period and multi-period demand flexibilities, and distributed generation placement at appropriate locations. The formulated optimization problem has been solved using nonlinear programming, which provides the nodal prices as byproducts of the solution. The electricity producers’ capability to exercise market power has been analyzed from their revenue and surplus indices, which have been obtained from nodal prices. Various case studies have been simulated on IEEE 30-bus system for quantitative determination of electricity producers’ market power. The results obtained are very interesting and demonstrate demand side strategies to tackle the electricity producers’ market power with actual and strategic bidding under normal and congested system conditions.
Student and teacher beliefs about oral corrective feedback in junior secondary English classrooms
Authors: Ye Xuejun , Hu Guangwei 
Published: February 2024

Abstract
Beliefs about oral corrective feedback, especially those held by young EFL learners, are under-researched. This paper reports on a study designed to investigate whether Chinese junior secondary students and teachers share similar beliefs about oral corrective feedback (OCF) in English instruction and how students’ English proficiency may relate to their OCF beliefs. A questionnaire was completed by 87 teachers and 597 students, and semi-structured interviews were conducted with 15 students with varying English proficiency. Statistical analyses of the questionnaire data found significant differences between student and teacher beliefs with respect to general attitude toward OCF, uptake of OCF, preference for certain types of OCF, and provision of OCF based on the gravity of errors. Students at different proficiency levels were also found to hold different beliefs about the timing and uptake of OCF. A content analysis of the interviews revealed more detailed similarities and differences between the OCF views held by students with varying English proficiency. These findings suggest that student beliefs are shaped by various individual, situational, contextual and cultural factors. Pedagogical efforts that can be made to maximize the effects of OCF in the classroom are discussed in light of these findings.
Therapeutic potential of flavonoids in ovalbumin induced asthma in mice model
Authors: Singh Vedpal , Singh Rohit , Dhanabal Sangai P. , Katrolia Archita 
Published: February 2024

Abstract

Objectives

Desmodium triquetrum DC (Fabaceae) is a plant commonly used in Indian traditional medicine to treat allergies. Asthma is a severe condition, with an estimated 300 million deaths annually, which could increase to 400 million by 2025. Flavonoids, a class of compounds found in many plants, have been found to have beneficial effects in treating asthma. In this study, researchers focused on three flavonoids, Baicalein, Naringin, and Neohesperidin, derived from Desmodium triquetrum DC, to investigate their potential as a treatment for asthma.

Methods
The study used an aerosolized ovalbumin-induced asthma model to evaluate the effects of the flavonoids on various substances in bronchoalveolar lavage fluid, including total differential leukocyte, nitrite, nitrate, TNF, IL-4, and IL-13. The researchers also measured the levels of myeloperoxidase and malondialdehyde in the lungs.

Results
The results showed that ovalbumin-induced airway hyper-responsiveness led to a significant increase in pro-inflammatory cytokine levels. However, the flavonoids significantly decreased the severity of airway inflammation. Histopathology results also supported the effectiveness of the flavonoids. These findings suggest that these flavonoids could be a supplementary and alternative treatment for asthma by inhibiting the pro-inflammatory pathway.

Conclusions
The findings suggest that the isolated compounds have the potential to act cumulatively to decrease the levels of the tested cytokines, normalize eosinophil and activated lymphocyte counts, and significantly reduce MPO and MDA. This indicates a possible respiratory mechanism of action for the drugs.