bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of serum fractalkine level as potential role for complications in splenectomized and non-splenectomized patients with β-thalassemia major
Authors: Awad Ayat Saeed , Ali Hanaa Addai , Althalmi Safaa Abdazahra Alwan 
Published: February 2024

Introduction: Thalassemia is a serious genetic blood related condition characterized by a lack of or malfunctioning hemoglobin in the RBCs. One of the most widespread inherited disorders is beta thalassemia (β-TM). The high susceptibility to infection in these individuals' is related to high mortality and morbidity rates. Fractalkine is known as CX3C chemokine ligand 1 (CX3CL1), which contains a total of 371 amino acid, and participates in a number of functions, including repair of tissues after injury, immunological response during inflammation, and chemotaxis effet.
Methodology: A case control study, containing sixty patients recognized as suffering from β-TM, was conducted at Al Zahra Teaching Hospital, Najaf (Iraq). The patients were divided into two groups; splenectomized and non-splenectomized patients. The thalassemia disease was enrolled in the “Thalassemia Unit”. Suitable statistical techniques were used to analyze the outcomes.
Results: In the current study, a significant increase in serum level of CX3CL1 was found in patients with β-TM, especially in splenectomized group (14.914 ± 2.636), (P = 0.01) and non-splenectomy (13.816 ± 2.686), (P = 0.05) group as compared with control group (12.26 ± 1.797).The linear regression analysis showed that a significant positive correlation in ferritin with serum CX3CL1 level in splenectomy patients with β-TM group. ROC curve for CX3CL1 that might be diagnosis of patients with β-TM with an AUC of 0.757 (95% CI: 0.623-0.890), sensitivity and specificity equally 75% and 83.3%.
Conclusion: Increase level of CX3CL1 due to its interaction with CX3CR1 receptor may lead to buildup of inflammatory cells in the β-TM patients, blocking CX3CL1 signaling may be helpful for patients with β-TM.
Abbreviations: AUC – Area Under Curve; β-TM - Beta Thalassemia; ROC - Receiver Operating Characteristic UIBC - Unsaturated Iron-Binding Capacity test; TIBC - Total Iron-Binding Capacity
Key words: Thalassemia, β thalassemia major, Fractalkine
Citation: Awad AS, Ali HA, Althalmi SAA. Assessment of serum fractalkine level as potential role for complications in splenectomized and non-splenectomized patients with β-thalassemia. Anaesth. pain intensive care 2023;27(5):495−500; DOI: 10.35975/apic.v27i5.2302
Received: August 03, 2023; Reviewed: August 12, 2023; Accepted: August 14, 2023
Clinical spectrum and outcomes of cancer patients affected with COVID-19 in Indian population: A single-center retrospective study
Authors: Kakati Sonai Datta , Das Anupam , Ninu Marie , Kakati Barnali 
Published: February 2024

Introduction: Cancer patients affected with COVID-19 are at high risk of severe infection and death which depends upon their functional status, cancer type and treatment modality. In this study, we measured outcome by mortality and length of stay in hospital and intensive care unit, need of oxygen and respiratory assist devices and performance status after discharge.
Methodology: This retrospective observational study was carried out in active cancer patients with confirmed positive RT-PCR for SARS-CoV-2 between April 2021 and August 2021. Patients with cancer treated more than 6 months back, those in remission and home isolation were excluded. Demographic profile, cancer type, staging and treatment, severity of COVID, treatment, oxygen supplementation, as well as ICU and hospital stay were analyzed. Statistical analysis was done using descriptive and inferential analysis. Significance was assessed at 5% level of significance. Chi-square/ Fisher Exact test was used to find the significance of the study parameters on categorical scale between two or more groups, non-parametric setting for qualitative data analysis. Fisher Exact test was used when cell samples were very small. P £ 0.01 was considered as strongly significant.
Results: Out of 92 patients, there were 17 deaths (mortality 18.4%). Mortality was associated with cancer stage, comorbidities, severity of COVID symptoms, use of oxygen, high flow nasal cannula, non-invasive ventilation and decreased Eastern Cooperative Oncology Group score on discharge (P = 0.001). Age, raised C-reactive protein and D dimer levels were associated with increased severity of COVID-19.
Conclusion: Cancer patients with COVID-19 have increased morbidity and mortality affected by various factors related either to pre-existent cancer or the newly acquired COVID-19.
Abbreviations: CRP - C-reactive protein; ECOG - Eastern Cooperative Oncology Group score; RT-PCR - Reverse Transcriptase Polymerase Chain Reaction; HFNC - High Flow Nasal Cannula
Key words: COVID-19; Critical Illness; Neoplasms; Death; Oxygen
Citation: Kakati SD, Das A, Ninu M, Kakati B. Clinical spectrum and outcomes of cancer patients affected with COVID-19 in Indian population: A single-center retrospective study. Anaesth. pain intensive care 2023;27(5):506-512.
DOI: 10.35975/apic.v27i5.2305
Received: July 18, 2023; Reviewed: August 09, 2023; Accepted: August 17, 2023
Effectiveness of ultrasound-guided perineural hydro-dissection with 5% dextrose for pronator teres syndrome: a case series
Authors: Siahaan Yusak Mangara Tua 
Published: February 2024

Pronator teres syndrome (PTS) is s a proximal compressive neuropathy of the median nerve at the elbow level by the pronator teres muscle leading to pain and numbness in the area of the nerve distribution. Conservative treatment may be effective in 50-70% of cases with extremity rest and non-steroidal anti-inflammatory drugs, corticosteroids, and surgical decompression. Dextrose perineural hydro-dissection under ultrasound guidance is an interventional therapeutic option in cases of peripheral neuropathy due to nerve entrapment. This is a serial case study investigating the efficacy of dextrose perineural hydro-dissection for long-term pain relief in PTS. A numeric rating scale (NRS) and Quick-DASH (Quick-Disability of the Arm, Shoulder and Hand) were used to evaluate pre- and post-treatment states with ultrasound-guided 5% dextrose hydro-dissection therapy. All patients experienced satisfactory resolution on evaluation twelve months after treatment. In long-term evaluation, dextrose perineural hydro-dissection exhibits good clinical and functional outcomes for patients with PTS.
Abbreviations: CTS - carpal tunnel syndrome; HD - hydro-dissection; NRS - numeric rating scale; PTS - Pronator teres syndrome; Quick-DASH - Quick-Disability of the Arm, Shoulder and Hand
Key words: Pronator Syndrome; Pain; Perineural Hydro-Dissection; Median Neuropathy
Citation: Tua Siahaan YM. Effectiveness of ultrasound-guided perineural hydro-dissection with 5% dextrose for pronator teres syndrome: a case series. Anaesth. pain intensive care 2023;27(5):607−613; DOI:
10.35975/apic.v27i5.2318
Received: July 11, 2023; Reviewed: August 27, 2023; Accepted: August 27, 2023
Comparative effect of preoperative oral pregabalin 50 mg vs. 75 mg on nerve growth factor (NGF) levels in parturients undergoing cesarean section
Authors: Ahmad Muhammad Ramli , Harahap Muhammad Wirawan , Wirawan Nur Surya 
Published: February 2024

Background & objectives: Postoperative pain after cesarean section (CS) is a crucial problem faced by the parturients. Pregabalin is a choice of preventive analgesia to reduce neuropathic pain, inflammation, tissue irritation, and post-cesarean section pain. The purpose of this study was to compare the effect of giving pregabalin 50 mg or 75 mg in combination with paracetamol 1 g on nerve growth factor (NGF) levels after cesarean section.
Methodology: A prospective, comparative model was used in this study. The study took place at Mother and Children Hospital of Sitti Khadijah I, Makassar, Indonesia. A total of 30 patients who underwent CS were randomly divided into two groups; group P1 who received pregabalin 50 mg orally and 1 g paracetamol intravenously, 1 h before surgery (n = 15), and group P2 who received pregabalin 75 mg orally and 1 g paracetamol intravenously, 1 h before surgery (n = 15). Nerve Growth Factor (NGF) levels were measured 2 h before surgery, and at 4 and 6 h post-surgery. Data were analyzed by the Mann-Whitney test using SPSS 26.0.
Results: There was a decrease in NGF levels in the pregabalin 75 mg group at 6 h post-surgery, while in the pregabalin 50 mg group it tended to increase at 4 and 6 h post-surgery. In the pregabalin 50 mg group, there was a significant increase in NGF levels from measurements of NGF1 to NGF2 and NGF0 to NGF2 (P < 0.05), whereas, in the pregabalin 75 mg group, there was a significant decrease in NGF levels from measurements of NGF1 to NGF2 and NGF0 to NGF2 (P < 0.05).
Conclusion: The combination of pregabalin 75 mg orally with paracetamol 1 g intravenously is effective as perioperative multimodal analgesia by reducing nerve growth factor levels after cesarean section surgery.
Abbreviations: BDNF- brain-derived neurotrophic factor; CS- Cesarean section; GABA- Gamma Amino Butyric Acid; NGF- Nerve Growth Factor
Keywords: Cesarean section; Nerve Growth Factor (NGF); Postoperative; Pregabalin
Citation: Ahmad MR, Harahap MW, Wirawan NS. Comparison between pregabalin 50 mg and 75 mg on nerve growth factor (NGF) levels after cesarean section. Anaesth. pain intensive care 2022;27(6):721−725; DOI: 10.35975/apic.v27i6.2159
Received: February 20, 2923; Revised: July 11,2023; Accepted: October 29, 2023
Efficacy and safety of dexmedetomidine to prevent shivering in cesarean delivery under spinal anesthesia: a double-blind, randomized controlled trial
Authors: Md Adnan Wan Ahmad Asyraf Wan , Wan Hassan Wan Mohd Nazaruddin , Seevaunnamtum Praveena , Omar Sanihah Che , Nik Mohamad Nik Abdullah 
Published: February 2024

Background & objective: Postoperative shivering is a source of much discomfort to the patients following spinal anesthesia (SA), especially in patients undergoing cesarean delivery. The anesthetists have employed various medications and a variety of measures to prevent shivering in their patients. The objective of this study was to investigate the efficacy and safety of intravenous (IV) dexmedetomidine in preventing shivering in patients undergoing cesarean delivery under SA.
Methodology: This prospective, double-blind, randomized trial involved 62 parturients undergoing cesarean delivery under SA. They were randomly divided into two groups; patients in dexmedetomidine group (Group D, n = 31) received dexmedetomidine 0.5 µg/kg IV over 10 min followed by infusion of 0.4 µg/kg/h until the end of surgery; whilst patients in the control group (Group C, n = 31) received equivalent loading and infusion volume of 0.9% saline. Both groups were operated upon by a standardized spinal anesthesia technique. The occurrence of shivering, sedation score and hemodynamic parameters were recorded intraoperatively. The recording anesthetist was blinded regarding the study or the control groups.
Results: The occurrence of shivering was significantly reduced in Group D as compared to Group C (3.2% vs 64.5%, P < 0.001). Patients in Group D were more sedated as compared to Group C (51.6% vs 0%, P < 0.001). There was no statistically significant difference in systolic and diastolic blood pressure readings between both of the groups. Heart rates in Group D were significantly lower than the Group C but still were within normal physiological range.
Conclusion: IV dexmedetomidine was effective in reducing the occurrence of shivering but with significant sedative effect and lowering of heart rate than the placebo. Although the heart rates remained within normal range in both groups.
Key words: Anesthesia, Spinal; Cesarean; Dexmedetomidine; Shivering
Citation: Wan Md Adnan WAA, Wan Hassan WMN, Seevaunnamtum P, Omar SC, Nik Mohamad NA. Efficacy and safety of dexmedetomidine to prevent shivering in cesarean delivery under spinal anesthesia: a double-blind, randomized controlled trial. Anaesth. pain intensive care 2023;27(6):632−638; DOI: 10.35975/apic.v27i6.2346
Received: January 09, 2023; Reviewed: January 29, 2023; Accepted: February 08, 2023
Incidence and risk factors for delirium after open heart surgery with cardiopulmonary bypass
Authors: Nguyen Thang Toan , Ta Do Dinh , Ho Hai Sy , Duong Hung Duc 
Published: February 2024

Background & objectives: Postoperative delirium is a prevalent complication, particularly following cardiac surgery, and has detrimental effects on patient outcomes, including increased morbidity and mortality and prolonged stays in the intensive care unit. This study aims to estimate the incidence and identify the risk factors for delirium.
Methodology: This prospective observational study was conducted on adult patients undergoing open-heart surgery with cardiopulmonary bypass at the Cardiovascular Surgery Unit at Bachmai Hospital, Vietnam. The Confusion Assessment Method for the ICU (CAM-ICU) was utilized to assess delirium twice daily during the initial four days post-surgery. Perioperative variables were analyzed by univariable and multivariable logistic regression.
Results: Among the 285 patients included in this study, 56 were diagnosed with delirium using the CAM-ICU, representing a prevalence rate of 19.6%. Multivariate regression analysis revealed several independent risk factors for delirium, including advanced age (odd ratio - OR; 95% confidence interval-CI) (1.07; 1.03-1.10), a history of cerebrovascular accident (3.95; 1.31-11.84), prolonged cardiopulmonary bypass duration (1.02; 1.00-1.03), postoperative atrial fibrillation (2.47; 1.15-5.28), and opioid use time (13.65; 5.69-32.75).
Conclusion: The incidence of delirium after open heart surgery with cardiopulmonary bypass was 19.6%. Advanced age and a history of cerebrovascular accidents were identified as non-modifiable risk factors for postoperative delirium. Meanwhile, there were three modifiable risk factors, including cardiopulmonary bypass duration, atrial fibrillation, and the time of opioid administration.
Abbreviations: CAM-ICU: Confusion Assessment Method for the Intensive Care Unit
Key words: Postoperative Delirium; Risk Factors; Incidence; Open-Heart Surgery; Cardiac Surgery
Citation: Nguyen TT, Ta DD, Ho HS, Duong HD. Incidence and risk factors for delirium after open heart surgery with cardiopulmonary bypass. Anaesth. pain intensive care 2023;27(6):639−645; DOI: 10.35975/apic.v27i6.2354
Received: Oct 04, 2023; Revised: Oct 28, 2023; Accepted: Oct 31, 2023
“ESICM guidelines on acute respiratory distress syndrome 2023”- a short summary
Authors: Mansoor Faraz 
Published: February 2024

New European Society of Intensive Care Medicine (ESICM) guidelines on acute respiratory distress syndrome (ARDS) were published in June, 2023. This is the commentary and the comparison of changes to the previous guidelines that were published in 2017. These new guidelines are applicable to adult patients and cover only non-pharmacological respiratory support strategies that also cover ARDS due to coronavirus disease 2019 (COVID-19).
Abbreviations: AHRF- Acute Hypoxemic Respiratory Failure; ARDS- Acute Respiratory Distress Syndrome; ECMO- Extra Corporeal Membrane Oxygenation; ESICM- European Society of Intensive Care Medicine; CPAP- Continuous Positive Airway Pressure; HFNO- High Flow Nasal Oxygen; NIV- Non-invasive Ventilation; PEEP- Positive End Expiratory Pressure; RM- Recruitment Maneuvers
Key words: Acute Hypoxemic Respiratory Failure; Acute Respiratory Distress Syndrome’ Mechanical Ventilation; Extracorporeal Membrane Oxygenation; Prone Position; Non-Invasive Ventilation; Prognosis.
Citation: Mansoor F. “ESICM guidelines on acute respiratory distress syndrome 2023”- a short summary. Anaesth. pain intensive care 2024;28(1):155−158; DOI: 10.35975/apic.v28i1.2392
Received: October 05, 2023; Reviewed: January 07, 2024; Accepted: January 07, 2024
Performance of Islamic Financial: A Qualitative Study In Improving The Regional Economy
Authors: Nugroho Anton Priyo 
Published: February 2024

Islamic financial institutions offer resources that the community can employ to expand economic opportunities and strengthen the local economy. The primary competitive and productive force in the national economy is the regional economy. Because of this, the growth of micro, small, and medium-sized businesses must be the nation's top goal in terms of economic development. The purpose of this study is to demonstrate how Islamic financial institutions help local business owners achieve economic development. This kind of research is a literature review, using data sources found by using preset variable keywords to search Google Scholar. The role of financial institutions in the economy, including asset transfers, transactions, liquidity, and efficiency, is covered by the study's findings. The purpose of Islamic financial institutions is to advance and foster the integration of Islamic values, sharia, and customs into banking, finance, and associated industries
The Influence of the Marketing Mix on the Interests of Customers Using Murabahah's Financing Products
Authors: Hanifa Riri , Haqiqi Teuku Muhammad 
Published: February 2024

This study is intended to analyze the effect of product, price, location, and promotion on customer interest in utilizing murabahah financing at Bank Syariah Indonesia KCP Sungai Lilin. This research is a quantitative research method, and data dissemination is done by distributing questionnaires. The sample in this study was 100 respondents, so this questionnaire was distributed to 100 respondents. The technique of collecting data in this study used an accidental random sampling technique, namely the technique of determining the sample by selecting respondents randomly but with certain criteria that must represent the population to be studied. As for the collection of primary data used by researchers, it was obtained from questionnaires distributed to respondents. Furthermore, the collected data were analyzed using multiple regression analysis with the help of the SPSS version 26. The results of this study indicate that product and price partially have a positive and significant effect on customer interest, while location and, promotion do not have a positive and significant effect on customer interest. Simultaneously, the product, price, location and promotion variables together have a positive and significant influence on customer interest in utilizing murabahah financing at Bank Syariah Indonesia KCP Sungai Lilin.
Keywords : Product, Price, Location, Promotion, Customer Interest
Binding Number, $k$-Factor and Spectral Radius of Graphs
Authors: Fan Dandan , Lin Huiqiu 
Published: February 2024

The binding number $b(G)$ of a graph $G$ is the minimum value of $|N_{G}(X)|/|X|$ taken over all non-empty subsets $X$ of $V(G)$ such that $N_{G}(X)\neq V(G)$. The association between the binding number and toughness is intricately interconnected, as both metrics function as pivotal indicators for quantifying the vulnerability of a graph. The Brouwer-Gu Theorem asserts that for any $d$-regular connected graph $G$, the toughness $t(G)$ always at least $\frac{d}{\lambda}-1$, where $\lambda$ denotes the second largest absolute eigenvalue of the adjacency matrix. Inspired by the work of Brouwer and Gu, in this paper, we investigate $b(G)$ from spectral perspectives, and provide tight sufficient conditions in terms of the spectral radius of a graph $G$ to guarantee $b(G)\geq r$. The study of the existence of $k$-factors in graphs is a classic problem in graph theory. Katerinis and Woodall state that every graph with order $n\geq 4k-6$ satisfying $b(G)\geq 2$ contains a $k$-factor where $k\geq 2$. This leaves the following question: which $1$-binding graphs have a $k$-factor? In this paper, we also provide the spectral radius conditions of $1$-binding graphs to contain a perfect matching and a $2$-factor, respectively.
KOMPETENSI GURU PAUD DALAM PEMBELAJARAN DI TK NEGERI NASARET WERE
Authors: Palu Maria Fatima 
Published: February 2024

Penelitian ini bertujuan untuk menggali sejauh mana kompetensi yang dimiliki oleh guru PAUD di TK Negeri Nasaret Were. Kompetensi yang dimaksudkan mencakup kompetensi pedagogik, kompetensi profesional, kompetensi sosial dan kompetensi kepribadian. Penelitian yang dilakukan di TK Negeri Nasaret Were dengan subyek penelitian adalah guru Paud. Judul penelitian kami yaitu “Kompetensi Guru PAUD DalamPembelajaran di TK Negeri Nasaret Were. Pengumpulan data yang digunakan yaitu observasi, wawancara dan dokumentasi yang diperoleh langsung di lapangan. Adapun hasil penelitian yang diperoleh dalam pengembangan kompetensi guru PAUD dalam pembelajaran di TK Negeri Nasaret Were yaitu profesional guru sangat terkait dengan kemampuan untuk mewujudkan serta mengaktualisasi kompetensi yang diperyaratkanbagisemuaguru.Kompetensi yang dimiliki guru menunjukankualitas guru yang sebenarnya.Kompetensitersebutterwujuddalambentukpenguasaanpengetahuan ,keterampilanmaupunsikapprofessionaldalammenjalankantugasnya .Kompetensiprofesional:dari hasil penelitian ditemukan bahwa guru di TKK Nazareth Were telah memahami materi yang harus diajarkan kepada anak.Kompetensipedagogik: guru TKK Nazareth Were dalam merencanakan kegiatan pembelajaran anak usia dini dinilai cukup baik. Kompetensi kepribadian: dari hasil wawancara bersama kepala sekolah diketahui bahwa setiap guru memiliki kepribadian dan karakter yang berbeda. Para guru menjalankan tugas yang diberikan dengan rasa tanggung jawab serta berusaha semaksimal mungkin merencanakan kegiatan belajar untuk hari selanjutnya. kompetensi sosial : hasil penelitian menunjukan bahwa, program yang melibatkan kerja sama antara lembaga dengan orang tua atau masyarakat masih sangat minim. Dari hasil penelitian terkait kompetensi guru PAUD yang dilakukan di TKK Nazareth Were dapat disimpulkan bahwa kompetensi guru PAUD masih harus ditingkatkan. Kompetensi yang harus ditingkatkan adalah Kompetensi social. Guru harus lebih meningkatkan partisipasi aktif dari orang tua dan masyarakat dalam program pembelajaran PAUD agar lebih berkualitas.

Kata Kunci:Kompetensi Guru, Profesionalitas, PendidikanAnakUsiaDini
PENERAPAN MODEL PEMBELAJARAN THINK-PAIR-SHARE UNTUK MENINGKATKAN KEAKTIFAN DAN KOMPETENSI MATEMATIKA SISWA KELAS XII IPA 5 SMA NEGERI 4 SINGARAJA
Authors: Marsilawati Ni Made Sri 
Published: February 2024

Penelitian ini merupakan penelitian tindakan kelas yang terdiri dari dua siklus. Subjek penelitian berjumlah 36 orang dengan 19 orang laki-laki dan 16 orang perempuan. Teknik pengumpulan data menggunakan lembar observasi, tes hasil belajar matematikan dan angket respon siswa. Data yang diperoleh dianalisis dengan menggunakan analisis statistik deskriptif. Hasil penelitiannya yaitu: 1) Penerapan model pembelajaran Think-Pair-Share dalam pembelajaran matematika dapat meningkatkan keaktifan belajar matematika siswa kelas XII IPA 5 SMA Negeri 4 Singaraja. 2) Penerapan model pembelajaran Think-Pair-Share dalam pembelajaran matematika dapat meningkatkan kompetensi matematika siswa kelas XII IPA 5 SMA Negeri 4 Singaraja. 3) Respon siswa kelas XII IPA 5 SMA Negeri 4 Singaraja terhadap penerapan model pembelajaran Think-Pair-Share dalam pembelajaran matematika adalah positif. Berdasarkan temuan-temuan tersebut dapat disimpulkan bahwa penerapan model pembelajaran Think-Pair-Share dalam pembelajaran matematika dapat meningkatkan keaktifan dan komptensi matematika siswa kelas XII IPA 5 SMA Negeri 4 Singaraja Semester Ganjil Tahun Pelajaran 2016/ 2017.