bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of sugar in coffee and tea and long-term risk of mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Authors: Treskes Roderick W. , Clausen Johan , Marott Jacob L. , Jensen Gorm B. , Holtermann Andreas , Gyntelberg Finn , Jensen Magnus T. 
Published: October 2023

Background
Tea and coffee are the most consumed beverages worldwide and very often sweetened with sugar. However, the association between the use of sugar in tea or coffee and adverse events is currently unclear.

Objectives
To investigate the association between the addition of sugar to coffee or tea, and the risk of all-cause mortality, cardiovascular mortality, cancer mortality and incident diabetes mellitus.

Methods
Participants from the prospective Copenhagen Male Study, included from 1985 to 1986, without cardiovascular disease, cancer or diabetes mellitus at inclusion, who reported regular coffee or tea consumption were included. Self-reported number of cups of coffee and tea and use of sugar were derived from the study questionnaires. Quantity of sugar use was not reported. Primary outcome was all-cause mortality and secondary endpoints were cardiovascular mortality, cancer mortality and incident diabetes mellitus, all assessed through the Danish national registries. The association between adding sugar and all-cause mortality was analyzed by Cox regression analysis. Age, smoking status, daily alcohol intake, systolic blood pressure, body mass index, number of cups of coffee and/or tea consumed per day and socioeconomic status were included as covariates. Vital status of patients up and until 22.03.2017 was assessed. Sugar could be added to either coffee, tea or both.

Results
In total, 2923 men (mean age at inclusion: 63±5 years) were included, of which 1007 (34.5%) added sugar. In 32 years of follow-up, 2581 participants (88.3%) died, 1677 in the non-sugar group (87.5%) versus 904 in the sugar group (89.9%). Hazard ratio of the sugar group compared to the non-sugar group was 1.06 (95% CI 0.98;1.16) for all-cause mortality. An interaction term between number of cups of coffee and/or tea per day and adding sugar was 0.99 (0.96;1.01). A subgroup analysis of coffee-only drinkers showed a hazard ratio of 1.11 (0.99;1.26). The interaction term was 0.98 (0.94;1.02). Hazard ratios for the sugar group compared to the non-sugar group were 1.11 (95% CI 0.97;1.26) for cardiovascular disease mortality, 1.01 (95% CI 0.87;1.17) for cancer mortality and 1.04 (95% CI 0.79;1.36) for incident diabetes mellitus.

Conclusion
In the present population of Danish men, use of sugar in tea and/or coffee was not significantly associated with increased risk of mortality or incident diabetes.
The possibility of electrification in public transport bus services
Authors: Kruchina Vince 
Published: October 2023

From Shenzhen to Philadelphia and Izmir to Delhi, public bus operators around the world are increasingly using electric buses. Their choice is not only justified by support for the green transition or the reduction of background traffic noise: economic calculations regarding the entire life cycle cost also support the need for technological change. The article points out that the inclusion of electric vehicles in the service requires a complex approach and can bring a revolutionary change in our operation. The transport company can become a community service provider that occasionally provides balancing energy for energy supply systems (Vehicle-to-grid, i.e. V2G) or provides a virtual power plant service to the operators of photovoltaic power plants. The bus company can become a producer with independent network power generation capacity, which can sell the excess capacity it produces on the market to the owners of electric cars. The article presents the operating model that connects the transport, energy and battery industrial systems. Last but not least, batteries that have lost their capacity but are still usable can be resold for “storage” or other secondary purposes, even as uninterruptible power supplies. In order to implement the operation according to the model, Volánbusz Zrt. started building its data-driven ecosystem, which enables cost-optimized operation based on the data of an ever-growing electric bus fleet and the solutions of Industry 4.0 technology.
IMPLEMENTASI PENERBITAN KTP ELEKTRONIK BAGI WARGA NEGARA ASING DI KOTA SEMARANG
Authors: Azhari Ardiansyah Rizal , Susanto Sri Nur Hari , Juliani Henny 
Published: October 2023

Administrasi kependudukan merupakan rangkaian kegiatan penataan dan penertiban dalam penerbitan dokumen dan data kependudukan melalui pendaftaran penduduk, pencatatan sipil, pengelolaan informasi administrasi kependudukan serta pemanfaatannya. Tujuan dilakukannya penelitian ini adalah melakukan identifikasi dan analisis terhadap prosedur dalam pemberian izin tinggal bagi warga negara asing, implementasi penerbitan KTP Elektronik bagi warga negara asing, serta hambatan yang ditemui dan solusi dalam penerbitan KTP Elektronik bagi warga negara asing di Kota Semarang. Metode yang digunakan dalam penelitian ini adalah yuridis empiris dengan menerapkan spesifikasi penelitian deskriptif analitis. Jenis data yang digunakan adalah jenis data primer dari wawancara serta menggunakan data sekunder dari studi kepustakaan. Hasil yang diperoleh dari penelitian ini adalah persyaratan dan prosedur yang mengatur dalam pemberian izin tinggal bagi warga negara asing, implementasi dari penerbitan KTP-el bagi warga negara asing, dan apa saja faktor hambatan dan kendala yang ditemui dalam penerbitan KTP-el bagi warga negara asing di kota Semarang.
Epicardial placement of human placental membrane protects from heart injury in a swine model of myocardial infarction
Authors: Skaria Rinku S. , Lopez‐Pier Marissa A. , Kathuria Brij S. , Leber Christian J. , Langlais Paul R. , Aras Shravan G. , Khalpey Zain I. , Hitscherich Pamela G. , Chnari Evangelia , Long Marc , Churko Jared M. , Runyan Raymond B. , Konhilas John P. 
Published: October 2023

AbstractCardiac ischemic reperfusion injury (IRI) is paradoxically instigated by reestablishing blood‐flow to ischemic myocardium typically from a myocardial infarction (MI). Although revascularization following MI remains the standard of care, effective strategies remain limited to prevent or attenuate IRI. We hypothesized that epicardial placement of human placental amnion/chorion (HPAC) grafts will protect against IRI. Using a clinically relevant model of IRI, swine were subjected to 45 min percutaneous ischemia followed with (MI + HPAC, n = 3) or without (MI only, n = 3) HPAC. Cardiac function was assessed by echocardiography, and regional punch biopsies were collected 14 days post‐operatively. A deep phenotyping approach was implemented by using histological interrogation and incorporating global proteomics and transcriptomics in nonischemic, ischemic, and border zone biopsies. Our results established HPAC limited the extent of cardiac injury by 50% (11.0 ± 2.0% vs. 22.0 ± 3.0%, p = 0.039) and preserved ejection fraction in HPAC‐treated swine (46.8 ± 2.7% vs. 35.8 ± 4.5%, p = 0.014). We present comprehensive transcriptome and proteome profiles of infarct (IZ), border (BZ), and remote (RZ) zone punch biopsies from swine myocardium during the proliferative cardiac repair phase 14 days post‐MI. Both HPAC‐treated and untreated tissues showed regional dynamic responses, whereas only HPAC‐treated IZ revealed active immune and extracellular matrix remodeling. Decreased endoplasmic reticulum (ER)‐dependent protein secretion and increased antiapoptotic and anti‐inflammatory responses were measured in HPAC‐treated biopsies. We provide quantitative evidence HPAC reduced cardiac injury from MI in a preclinical swine model, establishing a potential new therapeutic strategy for IRI. Minimizing the impact of MI remains a central clinical challenge. We present a new strategy to attenuate post‐MI cardiac injury using HPAC in a swine model of IRI. Placement of HPAC membrane on the heart following MI minimizes ischemic damage, preserves cardiac function, and promotes anti‐inflammatory signaling pathways.
Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study
Authors: Yuan Xiaoyong , Lu Difei , Meng Shuyou , Yang Lihui , Yuan Geheng , Qi Xin , Wen Bing , Zhang Junqing , Guo Xiaohui 
Published: October 2023

Abstract
The objective of this study was to explore the clinical characteristics and prognosis of diabetic foot in hospitalized patients with diabetes in Tibet. To achieve that, patients hospitalized in People’s Hospital of Tibet Autonomous Region and diagnosed with diabetic foot ulcer (DFU) from January 1, 2016 to December 31, 2020 were enrolled in the study, and DFU cases of Peking University First Hospital were collected as control group. Analysis and comparison of clinical characteristics of DFU in plateau and plain areas were conducted. Normal distribution data or non-normal distribution data between groups were analyzed by t-test analysis or the nonparametric Mann–Whitney U test, and categorical variants were compared by Chi-square of Pearson. A total of 54 DFU cases were enrolled in the study in the People’s Hospital of Tibet Autonomous Region (Tibet group for short). Males accounted for 83.3% (45 cases) in Tibet group, which was higher than that of Peking University First Hospital (Beijing group for short), which accounted for 67.0%. Compared with the DFU patients in the Beijing group, the Tibet group was younger (58.11 ± 12.25 years vs 64.18 ± 11.37 years, P < 0.05), with a shorter disease duration (7.00 years vs 12.00 years, P < 0.05). In contrast, alcohol consumption was higher in the Tibet group (44.4 vs 27.4%, P < 0.05), and the number of patients with smoking habit was higher in the Beijing group (29.6 vs 43.7%, P < 0.05). The Tibet group had higher HbA1c (10.2 vs 8.7%, P < 0.05) and lower DFU proportion (22.2 vs 44.2%, P < 0.05). There was no statistically significant difference in the proportion of moderate to severe infections between the two groups (58.5 vs 59.6%, P = 0.887). Leukocytes (6.75 × 109/L vs 8.72 × 109/L, P < 0.05) and neutrophils (4.07 × 109/L vs 6.26 × 109/L, P < 0.05) in Tibet group were lower. Although the DFU amputation rate in the Tibet group was lower than that in the Beijing group (9.3 vs 29.8%, P < 0.05), there was no statistically significant difference between the two groups in terms of treatment cost, hospital stay, and mortality. In conclusion, patients with DFU in Tibet had a smaller age, shorter duration of diabetes, and more male predominance. The proportions of gangrene and amputation were lower in Tibet, with gangrene accounting for 80% of all amputees.
Functions operating on several multivariate distribution functions
Authors: Ressel Paul 
Published: October 2023

Abstract
Functions

f

f

on

[

0
,
1

]

m

{\left[0,1]}^{m}

such that every composition

f

∘

(

g

1

,

…

,

g

m

)

f\circ \left({g}_{1},\ldots ,{g}_{m})

with

d

d

-dimensional distribution functions

g

1

,

…

,

g

m

{g}_{1},\ldots ,{g}_{m}

is again a distribution function, turn out to be characterized by a very natural monotonicity condition, which for

d
=
2

d=2

means ultramodularity. For

m
=
1

m=1

(and

d
=
2

d=2

), this is equivalent with increasing convexity.
Investigation of the microstructure and mechanical properties of Mg–Al–Zn alloy joints formed by different laser welding processes
Authors: Luo Qi , Wang Shaogang , Guo Yingying 
Published: October 2023

Abstract
The microstructure and mechanical properties of Mg–Al–Zn alloy joints by using autogenous laser beam welding (LBW) and laser-MIG hybrid welding, respectively, are investigated. The results show that the weld formation of the hybrid welding joint is relatively good, and there are mainly α-Mg matrix phases and β-Mg17Al12 strengthening phases in the weld metal. The microstructure in the fusion zone (FZ) of the two joints is different. The LBW joint is composed of columnar crystal and equiaxed dendrite. The hybrid welding joint consists of fine equiaxed grains, and the grain size in the laser zone is larger than that in the arc zone. The microhardness in FZ is higher due to the precipitation of the β-Mg17Al12 phase in this region. Under the optimized welding procedure, the strength coefficient of the two joints is >90%. There are many dimples on the tensile fracture surface of the hybrid welding joint, which is characterized by the pattern of the ductile fracture.
Private Supply Management and Market Power in the U.S. Dairy Industry
Authors: Bolotova Yuliya V. 
Published: October 2023

Abstract
This research analyzes the U.S. cheese industry dynamics (changes in wholesale cheese prices, milk price, margins, and the nature of wholesale cheese pricing) in light of a herd retirement program implemented by the Cooperatives Working Together (CWT) in the period of 2003–2010, which led to an antitrust lawsuit filed by cheese buyers against a group of dairy cooperatives and a large settlement. Presuming that they had a Capper-Volstead Act immunity, the CWT cooperatives acted in a cartel-like manner to decrease milk supply to increase and stabilize milk prices received by dairy farmers. While the program may have modestly increased seller market power of dairy farmers, seller market power of dairy cooperatives involved in cheese manufacturing decreased. This is because the cost of milk used in cheese manufacturing increased at a higher rate than wholesale cheese prices, which caused wholesale cheese margins to decrease.
Multimodal meaning-making in student presentations: the impact of explicit feedback in a German as a foreign language classroom
Authors: Lindenberg Dennis 
Published: October 2023

Abstract
This study examines the impact of teacher feedback on seven students’ presentations on social and cultural topics held in a German-as-a-foreign language classroom in Japan. Following the submission of self-recorded presentation drafts on an online learning platform, students received explicit feedback on how their spoken commentary related to the visible information on slides derived from the theoretical insights of social semiotics and systemic functional linguistics. After allocating one class to revising their work, students presented their finalized presentations, which were video recorded, cut, and prepared for analysis. Subsequently, a total of 14 sections that underwent alterations in both the draft and in-class presentation were scrutinized following a qualitative multimodal discourse analytical framework. By demonstrating the differences between two students’ early drafts and their final in-class presentations, this study shows how adding verbal language that extended a slide’s content strengthened audience engagement through interpersonal functions in language, gaze, body orientation, and gesture. Further, restructuring and inserting additional entities on the PowerPoint slide helped emphasize the talk’s ideational components. The findings of this study have implications for multiliteracies pedagogy in a foreign language context, highlighting the importance of a holistic approach that considers language and other modes as complementary aspects of communication.
Recent advances in DNA nanomaterials for cancer diagnosis and treatment
Authors: Li Longjie , Wang Zhen , Zhang Xuehao , Deng Yukai , Mu Yaoqin , Li Jingrou , Wang Li-mei , Wang Hong-xun , Zhang Junlin , Gao Hengyi , Mao Yajie 
Published: October 2023

Abstract
The elucidation of the structural characteristics of deoxyribonucleic acid (DNA) by Watson and Crick, the advent of polymerase chain reaction technology, and the development of primer-synthesis methods, enable DNA to be replicated and transformed in an increasingly easy manner, such that it is among the most directed and evolving nanomaterials in molecular biology. Traditional cancer diagnosis methods are somewhat limited and are unable to meet existing needs; consequently, DNA nanostructures with wide ranging properties are receiving increasingly more attention because a number of DNA materials have been shown to exhibit diagnostic properties. Some DNA materials can functionally alter the biological behavior of cells, such as cell migration, cell proliferation, cell differentiation, autophagy, and anti-inflammatory effects. Some single-stranded DNA or ribonucleic acid with secondary structure through self-pairing, called aptamer, systematic evolution of ligands by exponential enrichment (SELEX), have targeting capabilities and can be applied to tumor targeted diagnosis and therapy. Several DNA nanomaterials with three-dimensional nanostructures and stable structures are being investigated as drug carrier systems to act on a variety of antitumor drugs or gene therapy agents. This article reviews the use of functionalized DNA nanostructures in cancer diagnosis and treatment applications. Various biosensors and carriers based on DNA nanostructures are introduced and chemical reactions related to the preparation of the carrier and the signal transduction mechanism of the sensor are discussed. Efficient carrier/biosensor platforms based on various structural developments and current DNA nanomaterial developments are also presented.
Spoofing Traffic Attack Recognition Algorithm for Wireless Communication Networks in a Smart City Based on Improved Machine Learning
Authors: Hao Liping , Ma Yinghui 
Published: October 2023

Abstract
It is difficult to find spoofing traffic attack information for a wireless communication network, which leads to poor performance of spoofing traffic attack identification. Therefore, a spoofing traffic attack recognition algorithm for wireless communication networks based on improved machine learning has been designed. The process of network traffic classification and several common network cheating traffic attacks are analyzed. A chaotic algorithm is used to search and collect wireless communication network data, and Min-Max and z-score are used to standardize the collected data. The risk assessment function of wireless communication network spoofing traffic attack is constructed, and the spoofing traffic attack is preliminarily determined according to the function. The convolutional neural network in machine learning is improved, and the preliminary judgment results are input into the improved convolutional neural network to identify the attack behavior. The experimental results show that the recall rate of this method for wireless communication network spoofing traffic attacks can reach 90.08 % at the highest level, and the identification process takes only 1,763 ms at the lowest level. It can control the false positive rate of attacks below 4.68 % and the false positive rate below 2.00 %, and the identification effect of spoofing traffic attacks is good.
Bond-Slip Model of Corrosion-Resistant Rebar and Fiber-Reinforced Seawater Sea-Sand Concrete
Authors: Zheng Hao , Wang Wei , Gao Chengqiang , Yuan Jian , Feng Jiang 
Published: October 2023

Abstract
To study the bond performance between fiber-reinforced seawater sea-sand concrete and corrosion-resistant rebars (glass fiber–reinforced polymer [GFRP] bars and epoxy resin–coated rebars) in extremely hot and humid marine environments, bond anchorage tests between reinforcement and seawater sea-sand concrete are conducted to study bond performance. The failure morphology of reinforced concrete was investigated, and the bond-slip curves of different types of rebar and concrete were compared. According to the research results, the addition of basalt and polypropylene fibers to seawater sea-sand concrete changed the distribution of bonding stress, which was conducive to an improvement in the anchorage efficiency of reinforcement and concrete. The chemical bonding performance between the fiber-reinforced seawater sea-sand concrete and rebar is improved, wherein the bond stress increases by 94.01 % at the beginning of the slip, and the residual bond stress increases by 91.72 %. Compared with ordinary seawater sea-sand concrete, the bonding strength between ordinary reinforced rebar and fiber-reinforced seawater sea-sand concrete increased by 20.75 %, and the bonding strength between the GFRP bar and fiber-reinforced concrete decreased by 15.37 %. Based on the friction mechanism of rebars and concrete, bonding strength models of ordinary rebar, epoxy resin–coated rebar, and GFRP bars with fiber-reinforced seawater sea-sand concrete are presented.
Cotranscriptional demethylation induces global loss of H3K4me2 from active genes in Arabidopsis
Authors: Mori Shusei , Oya Satoyo , Takahashi Mayumi , Takashima Kazuya , Inagaki Soichi , Kakutani Tetsuji 
Published: October 2023

AbstractBased on studies of animals and yeasts, methylation of histone H3 lysine 4 (H3K4me1/2/3, for mono‐, di‐, and tri‐methylation, respectively) is regarded as the key epigenetic modification of transcriptionally active genes. In plants, however, H3K4me2 correlates negatively with transcription, and the regulatory mechanisms of this counterintuitive H3K4me2 distribution in plants remain largely unexplored. A previous genetic screen for factors regulating plant regeneration identified Arabidopsis LYSINE‐SPECIFIC DEMETHYLASE 1‐LIKE 3 (LDL3), which is a major H3K4me2 demethylase. Here, we show that LDL3‐mediated H3K4me2 demethylation depends on the transcription elongation factor Paf1C and phosphorylation of the C‐terminal domain (CTD) of RNA polymerase II (RNAPII). In addition, LDL3 binds to phosphorylated RNAPII. These results suggest that LDL3 is recruited to transcribed genes by binding to elongating RNAPII and demethylates H3K4me2 cotranscriptionally. Importantly, the negative correlation between H3K4me2 and transcription is significantly attenuated in the ldl3 mutant, demonstrating the genome‐wide impacts of the transcription‐driven LDL3 pathway to control H3K4me2 in plants. Our findings implicate H3K4me2 demethylation in plants as chromatin records of transcriptional activity, which ensures robust gene control.