bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do ethnic disparities exist in disease burden and healthcare utilization of male breast cancer: a 9-year cohort study of 18.19 million adults in China
Authors: Chen Jieying , Qiao Liying , Qi Meng , Zhang Yunjing , Yan Ying , Kang Weiwei , Zhou Huziwei , Yu Yuelin , Ke Yalei , Jiang Yuling , Rao Yingting , Xu Lu , He Guohua , Ren Jing , Yan Xue , Deng Siwei , Yang Xinyu , Song Yutong , Yang Yingzi , Wen Qiaorui , Han Jing , Wu Yiwei , Liu Guozhen , Wang Mingyuan , Zhang Xiaoyu , Xi Yunfeng , Wang Shengfeng 
Published: January 2024

Abstract
Background
As a rare disease, male breast cancer (MBC) is of increasing concern in China. Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear. We aim to measure disease burden and healthcare utilization by ethnicity among male breast cancer patients in China.
Methods
A retrospective cohort study was established during 2012–2021 based on Inner Mongolia Regional Health Information Platform. Disease burden including incidence, 5-year prevalence, mortality, survival rate, and medical cost were analyzed.
Results
Among 630 participants (mean [SD] age, 59.4 [13.1] years), age-standardized rates of incidence were 1.2 (95% CI: 0.4–2.1) per 100000. All-cause mortality was 50.8 per 1000 person-years (95% CI: 42.4–60.4) but breast cancer-specific mortality was 5.5 per 1000 person-years (95% CI: 3.0-9.3). Regarding ethnicity, Mongolian had a higher age-standardized 5-year prevalence rate than Han (3.2[95% CI: 2.5-4.0] vs 2.3[95% CI: 1.7-3.0], P = 0.016), but no significant differences existed in incidence rates, survival rates, and risk of all-cause and breast cancer-specific mortality. Patients residing in areas of lower GDP level were associated with increased breast-cancer specific mortality (HR, 22.5, [95% CI: 1.6–325.0]; P = 0.022).
Conclusions
This study revealed a moderate disease burden and relatively lower healthcare utilization for male breast cancer in Inner Mongolia, China. No significant ethnic disparities existed in disease burden and healthcare utilization. However, we still demanded for increasing attention to male breast cancer due to the crucial influence of economic factors on potential ethnic disparities.
Numerical Analysis of the Equilibrium Composition and Structural Features of Coal Combustion Products
Authors: Rah Shaon Md Tariqur , Hashan Antor Mahamudul , Rah Sharon Md Mahabubur 
Published: January 2024

Abstract
Coal is one of the primary working substances in the fossil-based power generation sector. The objective of this study is to investigate the combustion process of coal and its associated environmental consequences. We conduct numerical simulations to analyze the intricate processes associated with coal burning, considering both proximal and ultimate properties of various coal variants. The structural features in the fluidized bed, such as porosity and mass concentration in relation to pressure distribution, along with the limit value of pressure of a plume of dust at theoretical combustion temperature, are thoroughly studied. Various chemical reactions that occur during the burning of coal are considered to calculate the equilibrium composition of combustion products. We determine how the excess temperature and the amount of oxygen present significantly affect the equilibrium composition of combustion products. The study's findings provide valuable insights into the behavior of coal burning and its associated impacts. The enhancement of efficiency and environmental sustainability in coal-fired power plants can be achieved by a comprehensive study of the structural features and equilibrium composition of combustion byproducts. This work contributes to the field of energy research by offering a thorough numerical analysis of coal combustion products. The study findings can be utilized to improve combustion processes, reduce emissions, and enhance combustion efficiency. In order to enhance the comprehensiveness of our findings, we propose the utilization of the computational fluid dynamics (CFD) methodology.
Climate change may not reduce but redistribute global tuna abundance
Authors: Chen Xin Jun , Wang Jintao , Kang Bin , Zhang Fang , Zhu JiangFeng 
Published: January 2024

Abstract

Tuna, an invaluable source of animal protein for humanity, faces significant challenges due to climate-induced disturbances in its oceanic habitat. The resultant alterations in spatial distribution and abundance of tuna have perturbed the balance between supply and demand for tuna seafood on a global scale. Understanding the intricate interplay of potential positive and negative effects of climate change on tuna abundance is crucial for prudently ensuring sustainable resource utilization. Based on global longline and purse seine tuna fisheries datasets (albacore tuna, bigeye tuna, skipjack tuna, and yellowfin tuna), we used extreme gradient boosting to construct species distribution models to investigate the effects of abiotic and biotic environmental variabilities on the distribution and abundance for the four tunas during 1995–2019 worldwide and then predict the expected changes end-of‐the‐century under five shared socio-economic pathway (SSP119, SSP126, SSP245, SSP370, SSP585) emission scenarios. The model identify that the physical factors have more influence than biological factors, and similarly, the environmental variable from deep layer have more influence than those from surface on the tuna spatiotemporal distribution in the perspective of ocean-wide scale. The anticipated findings indicate that key areas of tuna abundance are poised to undergo shifts ranging from 1 to 8 degrees in diverse directions. Aggregate abundance is expected to fluctuate exceeding 60%, either decreasing or increasing relative to the levels observed in the year 2000S. These changes are contingent upon the specific tuna species and the oceanic context. In the context of medium-high intensity emission scenarios (specifically SSP379 and SSP585), the complexities of these situations are heightened. The continual manifestations of climate change underscore the imperative to proactively administer tuna resources, with a focus on open ocean ecosystem dynamics and global seafood security.
The Single-Dependence Sequential Testing Problem for the Living Kidney Donor Workup Process
Authors: Nielsen Joshua , El-Amine Hadi , Gentili Monica , Koizumi Naoru 
Published: January 2024

Abstract
The Sequential Testing Problem (STP) seeks to minimize the total expected cost of administering a series of tests which determine the quality of a system. When the probabilities of passing or failing a test are independent there exist many methods to solve the problem efficiently, but there is little research exploring the effect of dependency between tests. Motivated by the process of evaluating living kidney donors, we explore a variant of the STP which assumes that the probability of passing a given test is conditional upon passing the preceding test, and refer to this variant as the Single-Dependence Sequential Testing Problem (SDSTP). We present an optimization model to solve the SDSTP to optimality and simple - but effective methods to approximate the solution. Though we conjecture that the problem is NP-Complete, our experiments show that the model can be solved to optimality for many practical applications where the set of tests is small (say, less than 20), and our proposed algorithms also find near-optimal solutions in rapid time even for large numbers of tests.
Efficient Nonlinear Model Predictive and Active Disturbance Rejection Control for Trajectory Tracking of Unmanned Vehicles
Authors: Wang Hongwei , Liu Chenyu , Zhang Qingqing , Wang Liqiang 
Published: January 2024

Abstract
This article proposes an efficient trajectory tracking control strategy of unmanned vehicles. The method is based on nonlinear model predictive control (NMPC) and active disturbance reject control (ADRC). The designed control algorithm considers three challenges including nonlinear characteristics, multiple constraints and external disturbance. First, NMPC method is presented for the nonlinear vehicle model with multiple constraints. To relax inequality constraints and reduce the heavy calculation burden, the penalty term with the variable factor is added to the cost function, an improved continuous/generalized minimum residual method is proposed to solve NMPC online optimization problem. Then, an ADRC scheme is deigned to estimate the unknown disturbance via extended state observer, and compensate them by feedback control law in real time, the corresponding parameters are obtained by novel particle swarm optimization algorithm to further improve the control precision. It ensures the stability to a certain extent. Finally, the results indicate the designed algorithm can raise the calculation efficiency and meet the real-time requirements, and obviously increase the tracking accuracy and robustness performance.
An assessment of the implementation of HIV in the Workplace Policy, an anti- stigma and discrimination policy in Akwa Ibom State, Nigeria: A cross-sectional descriptive study
Authors: Idiong Helen M. , Ekanem Anyiekere M. , Nwanja Esther , Idiong Prince E. , Udofia Emilia A. 
Published: January 2024

Abstract
Background
Nigeria, like other countries in the world, has adopted policies to facilitate the implementation of HIV programs. One such policy, the HIV in the Workplace policy (HIV WPP), is an anti-stigma and discrimination policy that aims at protecting the rights of Persons living with HIV (PLHIV) in the workplace. Akwa Ibom State, one of the thirty-six states in Nigeria, adopted this policy in 2014. However, since its adoption, its implementation has not been assessed. This study aimed to assess the implementation of the HIV WPP in the state.
Methods
A cross-sectional study using a mixed methods approach was conducted for 591 consecutively recruited employees and 43 employers/ decision-makers across 23 organizations in Akwa Ibom State, Nigeria. The data were collected from October 2022 to February 2023. Seven criteria were used to assess policy implementation. They included policy availability, socio-economic and political contexts, stakeholders’ involvement, resource availability, leadership, operations and feedback. Scores above 70% were regarded as optimal policy implementation. Results were analyzed using SPSS 15.1 for quantitative and NVivo 10 for qualitative data.
Results
The study showed that 95% of organizations assessed had sub-optimal implementation (86.4% non-implementation and 9.1% poor implementation) of the AKS HIV WPP. Of the seven criteria used to assess policy implementation, the policy implementation failed on all points except one, socio-political environment. Prolonged engagement with donor agencies provided a good socio-political environment resulting in increased awareness of HIV in the state. However, only one (4.6%) organization, a private organization, fully implemented the policy on the seven domains of policy implementation. Most organizations had no HIV WPP policy (95.4%), no HIV committee (72.7%), inadequate resources (73.1%), and sub-optimal involvement of their leadership (59.2). There was a statistically significant association between the type of organization and the level of implementation of the AKS HIV WPP (p = 0.004).
Conclusion
The implementation of the AKS HIV WPP was poor due to many factors ranging from the unavailability of the document to lack of structures for its operationalization. It is recommended that the Akwa Ibom State Agency for the Control of AIDS (AKSACA) initiates and operationalizes the structures for its implementation through public-private collaboration. The availability of HIV-related organizational practices should provide a rationale for translating the state’s anti-stigma policy into organizational policies.
Hepatic Artery Stenosis Following Adult Liver Transplantation: Evaluation of Different Endovascular Treatment Approaches
Authors: Desai Sagar V. , Natarajan Balasubramani , Khanna Vinit , Brady Paul 
Published: January 2024

Abstract

Purpose:
To evaluate the efficacy and safety of hepatic artery interventions (HAI) versus extra-hepatic arterial interventions (EHAI) when managing clinically significant hepatic artery stenosis (HAS) after adult orthotopic liver transplantation.
Materials and Methods:
A single-center retrospective cohort analysis was conducted on liver transplant patients who underwent intervention for clinically significant HAS from September 2012 to September 2021. The HAI treatment arm included hepatic artery angioplasty and/or stent placement while the EHAI treatment arm comprised of non-hepatic visceral artery embolization. Primary outcomes included peri-procedural complications and 1-year liver-related deaths. Secondary outcomes included biliary ischemic events, longitudinal trends in liver enzymes and ultrasound parameters pre-and post-intervention.
Results:
The HAI arm included 21 procedures in 18 patients and the EHAI arm included 27 procedures in 22 patients. There were increased 1-year liver-related deaths (10% [2/21] vs 0% [0/27], p=0.10) and complications (29% [6/21] vs 4% [1/27], p=0.015) in the HAI group compared to the EHAI group. Both HAI and EHAI groups exhibited similar improvements in transaminitis including changes of ALT (-72 U/L vs -112.5 U/L, p=0.60) and AST (-58 U/L vs -48 U/L, p=0.56) at 1-month post-procedure. Both treatment arms demonstrated increases in post-procedural peak systolic velocity of the hepatic artery, while the HAI group also showed significant improvement in resistive indices following the intervention.
Conclusion:
Direct hepatic artery interventions remain the definitive treatment for clinically significant hepatic artery stenosis; however, non-hepatic visceral artery embolization can be considered a safe alternative intervention in cases of unfavorable hepatic anatomy.
11ip lymph node may play as N2 stage in right middle NSCLC
Authors: Han Xu , Zhang Wenjing , Jiang Wenjun 
Published: January 2024

Abstract
Background Right middle lobe NSCLC has a worse prognosis compared to other lobes possibly due to the lower number of lymph node dissections in surgery.So,we investigate the clinical significance of #11ip lymph node(LN) metastasis in right middle lobe NSCLC.Methods Symbolize the right lung #11 LN as superior 11(#11s), anterior 11(#11ia), and posterior 11(#11ip), based on their adjacency to the superior lobar bronchus, the middle lobar bronchus, and the region between right dorsal segmental bronchus and intermediate bronchus of right lung respectively in the view of single-port thoracoscopic surgery. The clinical data of mediastinal and #11 LN metastasis in 80 cases of right middle lobe NSCLC who were underwent surgical pulmonary resection from 2015–2022 were analyzed retrospectively and one case of #11ip LN metastasis retrogradely from #7 LN in bladder cancer was reported.Results None of 32 patients with pure ground-glass nodule (pGGN) were found to have lymph node metastasis (LNM). Out of the 48 patients with mixed ground-glass nodule (mGGN), no case with #11ip LNM was found in N1 cases(n = 6), but there was one case of #11ip LNM in N2 cases(n = 6).This tumor was in lateral segment and > 2 cm. #11ip LN resection with undifferentiated dorsal oblique fissure need more operative time than those with differentiated dorsal oblique fissure(149.32m to109.68m,p < 0.05) ,but postoperative drainage extubation time has no difference(5.22 days to 4 days,p = 0.116) and the postoperative drainage volume has no difference either (823.33ml to 607.14ml,p = 0.100). In addition, the survival period of N2 patient with #11ip LNM is 6 months.Conclusion To right middle lobe NSCLC with pGGN, #11ip LN dissection or biopsy is not necessary.Presenting as mGGN, #11ip LN should be dissected or biopsied particularly #4 or #7 LNM were found during surgery. #11ip LNM has a worse prognosis and may play as N2 stage in right middle lobe NSCLC.
The Impact of Utilizing Electronic Information Databases on Evidence-Based Practice Among Iranian Pharmacists: A Simulated-Based Survey.
Authors: Pourbala Hooman , Mohammadnezhad Ghader , Esmaily Hadi 
Published: January 2024

Abstract
Background: Evidence-based medicine (EBM) involves the conscious and careful utilization of the most reliable evidence available when making decisions regarding patient care. EBM can improve treatment plan success, patient compliance, rational use of medications, and healthcare costs.
Objectives: This study evaluated the knowledge, attitude, and practice of pharmacists regarding EBM utilization in community pharmacies.
Methods: A short questionnaire designed and validated to assess the knowledge and attitudes of community pharmacists. A simulated-patient method (SPM) was used to evaluate the practice one week after completing the questionnaire.
Results and Discussion: Within 284 pharmacy visits, the results of 200 pharmacists were collected entirely. The average knowledge score was 37.91 ± 15.4 out of 100. The pharmacists aged 24-29 demonstrated higher knowledge levels than older pharmacists (P=0.042). Furthermore, those who consult more than 30 prescriptions daily showcased a higher knowledge level (P=0.024). Additionally, it was found that pharmacists who utilized the UpToDate® clinical resource exhibited greater knowledge and practice in comparison to others (P<0.001). Most pharmacists had a positive attitude towards EBM and its implementation in the pharmacy (99.5%). The mean score of practice was 50.34 ± 21.35. A direct association was detected between knowledge and practice (r=0.73, P=0.023). There was no association between pharmacists' attitudes and their practice scores.
Conclusion: Most pharmacists agreed about the crucial need to incorporate EBM into pharmacy practices. Pharmacists with advanced knowledge of EBM and using UpToDate® showed better knowledge and practice.
Registration code: https://ethics.research.ac.ir/EthicsProposalView.php?id=152834
Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.
Authors: Yanagisawa Toshiki , Hayashi Koichiro , Tsuchiya Akira , Kishida Ryo , Ishikawa Kunio 
Published: January 2024

Abstract
Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granules from bone defects. Although covering the defect with a barrier membrane prevents granule emanation, this procedure is troublesome. To resolve these problems, we fabricated bioresorbable mesh cages (BMCs) in this study. Bone graft granules composed of carbonate apatite alone (Gr) and bioresorbable mesh cages (BMCs/Gr) introduced the bone graft granules and were implanted into the bone defect in the rabbit femur. Micro-computed tomography and histological analysis were conducted at 4 and 12 weeks after implantation. Osteoprogenitors in the bloodstream from the host bone passed through the pores of BMCs, penetrated the porous structure of graft granules, and might interact with individual granules. Then bone remodeling could progress actively and new bone was formed. The new bone formation was similar to the host bone at 12 weeks and there were minimal signs of local tissue inflammation. BMCs/Gr could reduce the risk of unwanted new bone formation occurring due to loss of granules from the bone defects compared with Gr because BMCs enclosed granules and prevent granules leakage from bone defects and BMCs could not induce unfavorable effects to forme new bone. Additionally, BMCs/Gr could keep specific amounts of granules assembled in one place, avoid displacement of granules to unintended locations, and carry easily. These results demonstrated that BMCs/Gr was effective in bone regeneration and improved clinical handling.
CD56 bright NK cell expansion correlated with EBV reactivation control post allogeneic hematopoietic stem cell transplantation
Authors: Juan Xie , Fan Zeying , Cao Xunhong , Shang Qian-nan , Liu Xuefei , Zhao Xiaosu , Chang Yingjun , Wang Yu , Xu Lanping , Zhang Xiaohui , Liu Kaiyan , Huang Xiaojun , Zhao Xiangyu 
Published: January 2024

Abstract
Natural killer (NK) cells are equipped with anti-Epstein-Barr virus (EBV) function, however，whether EBV infection will affect NK cells reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. To identify the characteristics of NK cells, we prospectively enrolled 22 patients with malignant hematological disease who occurred EBV reactivation or not post allo-HSCT. We found that that EBV infection resulted in the expansion of CD56bright and NKG2A+KIR- NK subsets ,and decreased the cytotoxicity function of NK cells. The percentages of NKG2A+KIR- NK cells were higher in patients who progressed into post-transplant lymphoproliferative disorder (PTLD) than EBV viremia patients, which also correlated with decreased proliferation and cytotoxic function. By screening the activation receptors of NK cells, we found the DNAM1+CD56bright NK cells is significantly increased after EBV stimulation. We found that DNAM1 is essential for EBV induced NK cells activation. After blocking DNAM1 on NK cells, the cytokine release against EBV-transformed lymphoblastoid cell lines(EBV-LCL) of CD56bright NK cells were significantly decreased. Anti-DNAM1 of NK cells diminished the clearance of EBV-LCL cells in EBV-related tumor mice model. A prospective cohort showed that old donor age was an independent risk factor for EBV infection. Rapid CD56bri expansion and high expression of DNAM-1 on CD56bri NK cells in response to EBV reactivation correlated with rapid EBV clearance post allo-HSCT in patients with younger donors. In summary, our data showed that high expression of DNAM-1 receptors on NK cell may participate protective CD56bri NK cells response to EBV infection after allo-HSCT.
The impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran: an interrupted time series analysis
Authors: Beiranvand Siavash , Behzadifar Meysam , Aryankhesal Aidin , Ehsanzadeh Seyed Jafar , Teli Banafshe Darvishi , Behzadifar Masoud 
Published: January 2024

Abstract

Background: The Covid-19 pandemic has posed unprecedented challenges to healthcare systems worldwide, affecting routine medical services, including for cancer patients. This study investigates the impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran.
Methods: We interrupted time series analysis (ITSA) on data collected from electronic medical records. The ITSA methodology was employed to analyze monthly outpatient visits for patients with cancer data from March 2017 to January 2023 in Lorestan University of Medical Sciences.
Results: Following the announcement of Covid-19 in Iran, outpatient visits for patients with cancer decreased immediately, with a sharp mean of 247.08 visits per month. Subsequent waves in June 2020, September 2020, April 2021, July 2021, and January 2022 further affected outpatient visits. However, the initiation of Covid-19 vaccination, particularly for cancer patients, marked a positive turning point, leading to an increase in outpatient visits by 156.39 per month.
Conclusion: Our study provides critical insights into the dynamic relationship between the Covid-19 pandemic, patient behavior, and cancer care utilization. The observed decrease in outpatient visits underscores the multifaceted challenges faced by cancer patients during the pandemic, while the positive influence of vaccination signals a pathway towards recovery. Tailored interventions, informed by the experiences of Iran, can guide global efforts to optimize cancer care in the post-pandemic era. As healthcare systems adapt to ongoing challenges, understanding the complex interplay between public health crises and patient behavior is crucial for shaping resilient and patient-centric healthcare systems.