bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cuidados paliativos: labor del fisioterapeuta para mejorar la calidad de vida del paciente en la atención primaria de salud y el equipo multidisciplinario
Authors: Rodríguez Espinosa Jorge Ricardo , Pérez García María Belén , Sanunga Guananga Edison Javier , Chipantiza Morales Katheryn Mishelle 
Published: February 2024

Introducción. Los cuidados paliativos incluyen diferentes técnicas de fisioterapia que ayudan a aliviar los síntomas físicos y emocionales para mejorar el funcionamiento diario de los pacientes. Este tipo de atención involucra enfermedades progresivas como metástasis cerebrales, enfermedad pulmonar obstructiva crónica, enfermedad de la neurona motora y esclerosis múltiple. En Ecuador los cuidados paliativos son importantes debido al aumento de enfermedades que requieren atención especializada, el cáncer es la principal causa de muerte en el país, lo que indica la necesidad de una mayor atención a los cuidados paliativos. Se estima que sólo el 3% de las personas que necesitan cuidados paliativos en Ecuador reciben una atención adecuada. Objetivo. El objetivo de este estudio fue analizar las intervenciones de fisioterapia en cuidados paliativos a través de un análisis crítico basado en artículos científicos de los últimos cinco años para identificar las diferentes técnicas utilizadas en pacientes en cuidados paliativos. Metodología. Se realizó una extensa búsqueda bibliográfica en bases de datos como Scielo, Google Scholar, Scopus, Proquest, Cengage, E-libros, Proqueste-bookcentral, etc. para determinar el estado del arte sobre el tema estudiado. Un total de 120 manuscritos en español, inglés y portugués, de los cuales se consideró el contenido de 65, constituyeron la muestra, palabras clave principales: enfermería, cuidados paliativos, bioética, 46 artículos científicos publicados en revistas indexadas en bases de datos regionales y globales. , para el período 2014-2018 y 2018, existen páginas relacionadas con documentos oficiales nacionales e internacionales en formato físico y electrónico, guías prácticas, manuales, trabajos obtenidos de repositorios institucionales, leyes y estadísticas relacionadas con el tema estudiado. Resultados. Los estudios revisados ​​demostraron que una variedad de intervenciones como reflexología, masajes, entrenamiento corporal estructurado, terapias cognitivas y de movimiento graduadas, planes de fisioterapia personalizados, TENS, terapias basadas en CGA y atención estándar pueden mejorar el funcionamiento vital de los pacientes y aliviar los síntomas de fatiga y dolor. Tener una enfermedad crónica. Conclusión. La fisioterapia desempeña un papel inherente en el equipo multidisciplinario de cuidados paliativos en la Atención Primaria de Salud, mejorando la función de vida de los pacientes que se considera que requieren dimensiones físicas y funcionales de la atención. Área de estudio general: salud y bienestar. Área de estudio específica: fisioterapia. Tipo de estudio: artículo original.
La mediación tributaria intraprocesal: ¿un mecanismo para eliminar la presunción penal establecida en el acta de determinación?
Authors: Herrera Capa Jorge Michael , Romero Jarrin Fabian Alejandro 
Published: February 2024

Introducción: Los métodos alternativos de solución de conflictos se han inmiscuido en gran parte de las ramas del derecho y; el ámbito tributario no ha sido la excepción, por lo que su aplicación no pretende limitar la competencia del juzgador para conocer una controversia, sino complementar y efectivizar su resolución. En la presente investigación se inicia analizando las normas vigentes en el Ecuador y como se desarrolla en el alcance tributario con relación a la eliminación de la presunción penal establecida en el acta de determinación, a partir de la revisión de fuentes bibliográficas y la norma interna. Se identificará la posibilidad de incurrir en la mediación tributaria intraprocesal, frente a los tipos penales que afectan al régimen de desarrollo, y la eficacia de las MASC, frente al resarcimiento del daño causado al Estado. Además, se describirá la percepción de normativa extranjera, que servirá para encaminar la aplicación de estos procedimientos. Objetivo: Analizar la mediación tributaria intraprocesal como un mecanismo que podría eliminar la presunción penal establecida en el acta de determinación. Metodología: Se aplicó el método hipotético – deductivo, enfocándonos en el planteamiento de una hipótesis relacionado con una visión de aplicación del objeto de estudio valorando la aceptación o refutación del proceso fundamentado. Resultados: Se demuestra que al determinar la presunción penal establecida en el acta de determinación, no podrá ser eliminada mediante el proceso de mediación intraprocesal en procedimiento ordinario; sin embargo se podría resolver dicho conflicto con la celebración del acta transaccional, antes de que concluya la etapa de instrucción fiscal, en ciertos tipos penales que se relacionan con el ámbito tributario, considerando que existe la posibilidad en los tipos penales que no excedan los cinco años de privación de libertad. Conclusiones: La mediación tributaria intraprocesal puede ser celebrada de acuerdo con los lineamientos establecidos en la norma interna, ya que, la conciliación no tiene un desarrollo especifico, por lo cual las directrices en cuanto a normativa extranjera serán pertinentes para un adecuado desarrollo de dicho procedimiento. Área de estudio general: Derecho. Área de estudio específica: Derecho tributario.
SMART BOOK MATHEMATIC FOR DIFABEL (SOMABEL): WEBSITE-BASED MATHEMATICS LEARNING MEDIA FOR MENTALLY DISABLED STUDENTS USING CARDBOARD WASTE
Authors: Rewan Jayadi  , Siska Yosmar  
Published: February 2024

Anak Berkebutuhan Khusus (ABK) memiliki keterbatasan secara fisik, mental, emosi, sosial, dan intelektual, dalam hal ini salah satu yang termasuk sebagai anak berkebutuhan khusus adalah tunagrahita, ini dikarenakan memiliki nilai intelengensia di bawah rata-rata dapat menjadi hambatan bagi mereka sehingga kesulitan untuk memahami materi pada proses pembelajaran terkhususnya matematika. Sehingga diperlukan suatu inovasi yang memiliki tujuan untuk menciptakan media pembelajaran matematika bagi anak tunagrahita dalam mendukung target SDGs 2030 (Sustainable Development Goals) yaitu Smart Book Mathematic for Difabel (SOMABEL) yang harapannya mampu mendukung mereka dalam menghadapi hambatan belajar matematika khususnya materi bangun datar. Metode penelitian yang dipilih adalah Research and Development (R&D), pengumpulan data yang dilakukan dengan studi kasus, studi Pustaka, observasi dan wawancara. Hasil penelitian menunjukkan bahwa media pembelajaran Somabel dapat meningkatkan semangat belajar siswa tunagrahita yang mana media ini secara langsung terintegrasi pada teknologi berbasis website, yang memiliki sekaligus melestarikan budaya Provinsi Bengkulu, serta desain buku dan media fisik yang menarik sehingga tidak membosankan dalam belajar materi matematika. Inovasi media pembelajaran ini juga membantu para guru dalam mengajar guru, karena selain bisa menjadi bahan referensi media ini juga tidak membosankan dan bisa menjadi pengetahuan tambahan untuk pengenalan budaya yang ada di Provinsi Bengkulu.
Kata kunci: Pembelajaran Matematika, Research and Development, Website
The role of cell-matrix adhesion and cell migration in breast tumor growth and progression
Authors: Chong Lor Huai , Yip Ai Kia , Farm Hui Jia , Mahmoud Lamees N. , Zeng Yukai , Chiam Keng-Hwee 
Published: February 2024

During breast cancer progression, there is typically increased collagen deposition resulting in elevated extracellular matrix rigidity. This results in changes to cell-matrix adhesion and cell migration, impacting processes such as the epithelial-mesenchymal transition (EMT) and metastasis. We aim to investigate the roles of cell-matrix adhesion and cell migration on breast tumor growth and progression by studying the impacts of different types of extracellular matrices and their rigidities. We embedded MCF7 spheroids within three-dimensional (3D) collagen matrices and agarose matrices. MCF7 cells adhere to collagen but not agarose. Contrasting the results between these two matrices allows us to infer the role of cell-matrix adhesion. We found that MCF7 spheroids exhibited the fastest growth rate when embedded in a collagen matrix with a rigidity of 5.1 kPa (0.5 mg/mL collagen), whereas, for the agarose matrix, the rigidity for the fastest growth rate is 15 kPa (1.0% agarose) instead. This discrepancy is attributable to the presence of cell adhesion molecules in the collagen matrix, which initiates collagen matrix remodeling and facilitates cell migration from the tumor through the EMT. As breast tumors do not adhere to agarose matrices, it is suitable to simulate the cell-cell interactions during the early stage of breast tumor growth. We conducted further analysis to characterize the stresses exerted by the expanding spheroid on the agarose matrix. We identified two distinct MCF7 cell populations, namely, those that are non-dividing and those that are dividing, which exerted low and high expansion stresses on the agarose matrix, respectively. We confirmed this using Western blot which showed the upregulation of proliferating cell nuclear antigen, a proliferation marker, in spheroids grown in the 1.0% agarose (≈13 kPa). By treating the embedded MCF7 spheroids with an inhibitor or activator of myosin contractility, we showed that the optimum spheroids’ growth can be increased or decreased, respectively. This finding suggests that tumor growth in the early stage, where cell-cell interaction is more prominent, is determined by actomyosin tension, which alters cell rounding pressure during cell division. However, when breast tumors begin generating collagen into the surrounding matrix, collagen remodeling triggers EMT to promote cell migration and invasion, ultimately leading to metastasis.
Transmission risk evaluation of transfusion blood containing low-density Babesia microti
Authors: Cai Yuchun , Xu Bin , Liu Xiufeng , Yang Wenwu , Mo Ziran , Zheng Bin , Chen Jiaxu , Hu Wei 
Published: February 2024

BackgroundBabesia is a unique apicomplexan parasite that specifically invades and proliferates in red blood cells and can be transmitted via blood transfusion, resulting in transfusion-transmitted babesiosis. However, detecting Babesia in blood before transfusion has not received enough attention, and the risk of transfusing blood containing a low density of Babesia microti (B. microti) is unclear, possibly threatening public health and wellness.PurposeThis study aimed to determine the lower detection limit of B. microti in blood and to evaluate the transmission risk of blood transfusion containing low-density B. microti.MethodsInfected BALB/c mouse models were established by transfusing infected whole blood with different infection rates and densities of B. microti. Microscopic examination, nested Polymerase Chain Reaction (nested PCR), and an enzyme-linked immunosorbent assay (ELISA) were used to evaluate the infection status of the mouse models. Meanwhile, the nested PCR detection limit of B. microti was obtained using pure B. microti DNA samples with serial concentrations and whole blood samples with different densities of B. microti-infected red blood cells. Thereafter, whole mouse blood with a B. microti density lower than that of the nested PCR detection limit and human blood samples infected with B. microti were transfused into healthy mice to assess the transmission risk in mouse models. The infection status of these mice was evaluated through microscopic examination, nested PCR tests, and ELISA.ResultsThe mice inoculated with different densities of B. microti reached the peak infection rate on different days. Overall, the higher the blood B. microti density was, the earlier the peak infection rate was reached. The levels of specific antibodies against B. microti in the blood of the infected mice increased sharply during the first 30 days of infection, reaching a peak level at 60 days post-infection, and maintaining a high level thereafter. The nested PCR detection limits of B. microti DNA and parasite density were 3 fg and 5.48 parasites/μL, respectively. The whole blood containing an extremely low density of B. microti and human blood samples infected with B. microti could infect mice, confirming the transmission risk of transfusing blood with low-density B. microti.ConclusionWhole blood containing extremely low density of B. microti poses a high transmission risk when transfused between mice and mice or human and mice, suggesting that Babesia detection should be considered by governments, hospitals, and disease prevention and control centers as a mandatory test before blood donation or transfusion.
Clinical effect of vein of Marshall ethanol infusion on mitral isthmus ablation
Authors: Ge Wei-Li , Lu Yi-Fei , Li Tao , Wang Ye , Yin Jie , Li Xin-Ran , Jiang Jian-Jun , Mi Ya-Fei , Tung Tao-Hsin , Yan Su-Hua 
Published: February 2024

PurposeThis study aimed to investigate the effect of Marshall ethanol infusion (VOM-Et) in the vein on mitral isthmus (MI) ablation.MethodsPatients with persistent atrial fibrillation (AF) were grouped into vein of VOM-Et combined with radiofrequency (RF) ablation (VOM-Et-RF) and RF groups. The primary outcome was MI block immediate block rate after surgery. Stratified analysis was also performed for factors affecting the outcome measures.ResultsA total of 118 consecutive patients underwent AF ablation at Taizhou Hospital of Zhejiang Province from January 2018 to December 2021. Successful bidirectional perimitral block was achieved in 96% of patients in VOM-Et-RF (69 of 72) and in 76% of patients in the RF group (35 of 46) (P &lt; 0.01). In the subgroup analysis, male sex, elder than 60 years, Left atrial diameter &lt;55 mm, and AF duration &lt;3 years were associated with the benefits of VOM-Et in AF Patients.ConclusionThe vein of Marshall ethanol infusion for catheter ablation can improve the MI block rate. Male sex, elder age, smaller Left atrial diameter and shorter AF duration may have significant benefits for VOM-Et.
Investigating the causal impact of polycystic ovary syndrome on gestational diabetes mellitus: a two-sample Mendelian randomization study
Authors: Guixue Guan , Yifu Pu , Xiaofeng Tang , Qian Sun , Yuan Gao , Wen Yang , Conghui Han , Zuobin Zhu 
Published: February 2024

IntroductionDetermining the causal relationship between polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) holds significant implications for GDM prevention and treatment. Despite numerous observational studies suggesting an association between PCOS and GDM, it remains unclear whether a definitive causal relationship exists between these two conditions and which specific features of PCOS contribute to increased incidence of GDM.MethodsThe causal relationship between polycystic ovary syndrome (PCOS), its characteristic indices, and gestational diabetes mellitus (GDM) was investigated using a two-sample Mendelian randomization study based on publicly available statistics from genome-wide association studies (GWAS). The inverse-variance weighted method was employed as the primary analytical approach to examine the association between PCOS, its characteristic indices, and GDM. MR Egger intercept was used to assess pleiotropy, while Q values and their corresponding P values were utilized to evaluate heterogeneity. It is important to note that this study adopts a two-sample MR design where PCOS and its characteristic indices are considered as exposures, while GDM is treated as an outcome.ResultsThe study results indicate that there is no causal relationship between PCOS and GDM (all methods P &gt; 0.05, 95% CI of OR values passed 1). The IVW OR value was 1.007 with a 95% CI of 0.906 to 1.119 and a P value of 0.904. Moreover, the MR Egger Q value was 8.141 with a P value of 0.701, while the IVW Q value was also 8.141 with a P value of 0.774, indicating no significant heterogeneity. Additionally, the MR Egger intercept was 0.0004, which was close to zero with a P value of 0.988, suggesting no pleiotropy. However, the study did find a causal relationship between several other factors such as testosterone, high-density lipoprotein, sex hormone-binding globulin, body mass index, waist-hip ratio, apolipoprotein A-I, number of children, diabetes illnesses of mother, father and siblings, hemoglobin A1c, fasting insulin, fasting blood glucose, years of schooling, and GDM based on the IVW method.ConclusionWe observed no association between genetically predicted PCOS and the risk of GDM, implying that PCOS itself does not confer an increased susceptibility to GDM. The presence of other PCOS-related factors such as testosterone, high-density lipoprotein, and sex hormone-binding globulin may elucidate the link between PCOS and GDM. Based on these findings, efforts aimed at preventing GDM in individuals with PCOS should prioritize those exhibiting high-risk features rather than encompassing all women with PCOS.
Study on multi-scenarios regulating strategy of land use conflict in urban agglomerations under the perspective of “three-zone space”: a case study of Harbin-Changchun urban agglomerations, China
Authors: Zheng Wei , Guo Bin , Su Hao , Liu Zijun 
Published: February 2024

Introduction: Against the background of rapid global urbanization, the urban space expansion has led to increasingly acute land-use conflicts. Accurately understanding the spatial and temporal evolution characteristics of land-use conflict patterns and measuring the level of spatial conflicts are crucial for intensifying sustainable use and management of land resources. Existing research focuses on analyzing the current status of land-use conflicts, while there is limited discussion on tracking spatial-temporal dynamic patterns and simulating future conflict trends.Method: In this paper, the level of spatial conflict was measured by constructing a spatial comprehensive conflict index (SCCI) model, and the spatio-temporal evolution characteristics of land use conflict in Harbin-Changchun urban agglomeration from 2000 to 2020 are discussed. In addition, the PLUS model is used to simulate and predict the pattern of land use conflict in 2030, finally put forward the control strategy.Results: Result shows that: (1) Over the past 20 years, urban space has expanded rapidly with two provincial capitals as growth poles. Land-use conflicts generally exhibit a distribution pattern of “high in the west and low in the east, high in the core and low in the periphery.” (2) During the past 20 years, conflicts have intensified initially and then eased. Severe uncontrolled conflicts are concentrated in the transition zone between urban and rural areas of urban agglomerations. (3) Agricultural space is the core resource and key area contested by different interest subjects in the process of land development and utilization.Discussion: The agricultural space priority scenario proves to be the most effective in controlling spatial conflicts. However, a single space priority scenario cannot adequately address multiple spatial rights and interests. Therefore, different spatial management modes should be implemented in different areas. The purpose of this paper is to provide scientific strategies and suggestions for controlling land-use conflicts in urban agglomerations and achieving sustainable development of regional land use.
Mendelian randomization analysis demonstrates the causal effects of IGF family members in diabetes
Authors: Li Xing , Tang Jie , Lin Sha , Liu Xuwei , Li Yifei 
Published: February 2024

BackgroundObservational studies have consistently shown significant associations between the IGF family and metabolic diseases, including diabetes. However, these associations can be influenced by confounding factors and reverse causation. This study aimed to assess the causal relationship between the IGF family and diabetes using Mendelian randomization (MR).MethodsWe conducted a two-sample MR analysis to investigate the causal effects of the IGF family on diabetes. Instrumental variables for the IGF family and diabetes were derived from summary-level statistics obtained from genome-wide association studies. Horizontal pleiotropy was assessed using MR-Egger regression and the weighted median method. We applied the inverse-variance weighted method as part of the conventional MR analysis to evaluate the causal impact of the IGF family on diabetes risk. To test the robustness of the results, we also employed MR-Egger regression, the weighted median method, and a leave-one-out analysis.ResultsOur study revealed that IGF-1 causally increases the risk of Type 2 Diabetes (T2D), while IGFBP-6, adiponectin and INSR decreases the risk (IGF-1, OR 1.02 [95% CI 1–1.03], p = 0.01; IGFBP-6, OR 0.92 [95% CI 0.87–0.98], p = 0.01; Adiponectin, OR 0.837 [95% CI 0.721–0.970], p = 0.018; INSR, OR 0.910 [95% CI 0.872–0.950], p = 1.52 × 10–5). Additionally, genetically lower levels of IGF-1 and IGFBP-5, along with higher levels of IGFBP-7, were associated with an increased risk of Type 1 Diabetes (T1D) (IGF-1, OR 0.981 [95% CI 0.963–0.999], p = 0.037; IGFBP-5, OR 0.882 [95% CI 0.778–0.999], p = 0.049; IGFBP-7, OR 1.103 [95% CI 1.008–1.206], p = 0.033).ConclusionIn summary, our investigation has unveiled causal relationships between specific IGF family members and T1D and T2D through MR analysis. Generally, the IGF family appears to reduce the risk of T1D, but it presents a more complex and controversial role in the context of T2D. These findings provide compelling evidence that T2D is intricately linked with developmental impairment. Our study results offer fresh insights into the pathogenesis and the significance of serum IGF family member concentrations in assessing diabetes risk.
Cognitive reserve and the risk of postoperative neurocognitive disorders in older age
Authors: Borchers Friedrich , Rumpel Miriam , Laubrock Jochen , Spies Claudia , Kozma Petra , Slooter Arjen , van Montfort Simone J. T. , Piper Sophie K. , Wiebach Janine , Winterer Georg , Pischon Tobias , Feinkohl Insa 
Published: February 2024

BackgroundPostoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are postoperative neurocognitive disorders (PNDs) that frequently occur in the aftermath of a surgical intervention. Cognitive reserve (CR) is a concept posited to explain why cognitive health varies between individuals. On this qualitative understanding of cognitive health, factors like IQ, education level, and occupational complexity can affect the impact of neuropathological processes on cognitive outcomes.MethodsWe investigated the association between CR and POD and CR and POCD on data from 713 patients aged≥65 years with elective surgery. Peak pre-morbid IQ was estimated from vocabulary. Occupational complexity was coded according to the Dictionary of Occupational Titles (DOT). Education level was classed according to the International Standard Classification of Education (ISCED). These three factors were used as proxies of CR. In a series of regression models, age, sex, depression, site of surgery, and several lifestyle and vascular factors were controlled for.ResultsPatients with a higher IQ had lower odds of developing POD. We found no significant association between the other two CR markers with POD. None of the CR markers was associated with POCD.ConclusionThe significant association of a higher IQ with lower POD risk allows for the stratification of elderly surgical patients by risk. This knowledge can aid the prevention and/or early detection of POD. Further research should attempt to determine the lack of associations of CR markers with POCD in our study.