bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Screening Models of (In Vivo And In Vitro) Used for the Study of Hepatoprotective Agents
Authors: Dubey Anubhav , Samra Samra , Sahu Vikram Kumar , Dash Sribatsa Lanchhana , Mishra Amit 
Published: October 2023

In order to evaluate hepatoprotective function, both in vitro and in vivo liver or hepatoprotective models have been constructed in the past. These methods examine a drug's potential to prevent or minimize liver damage in test animals. To express their effectiveness and safety in humans, new drugs must first travel through a number of developmental phases, beginning with the identification of their pharmacological characteristics in cellular and animal models. In the medical literature, there are many methods for measuring hepatoprotective efficacy in vivo and in vitro. Fresh hepatocytes are exposed to hepatotoxin treatment in in vitro models, and the effects of the test chemical on those cells are examined. To elicit liver damage in test animals, dangerous dosages of an identified hepatotoxin are administered in in vivo models. The test material is provided before, after, and simultaneously with the toxin treatment. Hepatitis in Long Evans and other chemical agents are commonly exploited to generate hepatotoxicity in experimental animals for the evaluation of hepatoprotective medications. Cinnamon rats, liver cirrhosis and necrosis, hepatic fibrosis brought on by carbon tetrachloride in rats, liver cirrhosis brought on by galactosamine, inhibition of proline hydroxylation, trans-heptic investigations model in dogs, etc. The many forms of in vivo and in vitro hepatoprotective screening models are explained in this article.
Development and Validation of an Enzymatic Assay for TMPRSS4: Evaluation of Molecular Inhibitors
Authors: Esram Poornima , Arumugam Premkumar 
Published: October 2023

TMPRSS4, a member of the transmembrane serine protease (TTSP) family, has earned significant attention due to its pronounced overexpression in various carcinoma types, involvement in disease processes, and viral entry. However, despite its pivotal role in disease biology, little is known about its structural characteristics and potential drug targets. Accurate measurement of TMPRSS4 activity is crucial for understanding its role in these disease processes and for developing potential therapeutic interventions. In this context, we have expressed and purified TMPRSS4 protein and report the development of an enzymatic assay for the quantitative measurement of TMPRSS4 activity. The assay is based on a synthetic fluorogenic peptide substrate that mimics the natural cleavage site of TMPRSS4/serine proteases substrates. The Assay development workflow includes enzyme preparation, optimization of assay materials, reagents, and conditions. The assay is further validated using a known serine protease inhibitor, Aprotinin. Our results demonstrate that the developed enzymatic assay exhibits a wide dynamic range and successfully applied the assay to assess molecular inhibitors predicted by our computational studies. In conclusion, our study presents a robust enzymatic assay for TMPRSS4 activity that provides researchers and clinicians with a valuable tool for studying this protease's function and potential clinical applications.
Analisis Sosiologi Sastra Dalam Cerpen “Mauthini” Karya Amani Ismail Berdasarkan Perspektif Alan Swingewood
Authors: Muamaroh Dzun Nur Nafi'ah , Maliyanah Alya Afifah , Fitriani Laily 
Published: October 2023

Literary works have a relationship with social conditions. such as in Mauthini's short story which discusses the state of the Palestinian people who are under attack by Israel. The purpose of this article: 1) To describe the portrait of the suffering experienced by the Palestinian people (2) To describe the portrait of the sacrifices of the Palestinian people during the uprising. This type of research is qualitative, descriptive, and literature. Data collection uses reading and note-taking techniques. The technical analysis of this research data is data reduction, data exposure and conclusion drawing. The results of this study have found a portrait of the suffering and sacrifice of the Palestinian people that shows the concept of the sociology of literature by Alan Swingewood. In the portrait of the suffering of the Palestinian population, there are 5 quotes that contain elements of suffering: (1) Wounded with blood. (2) Scream in heart (3) Victims fall. (4) Destruction of housing (5) Children victims of Israeli attacks. (6) Oppressed Palestine. In the portrait of the sacrifice of the Palestinian population kesimpulan, there are 3 quotes about the suffering of the Palestinian population: (1) Sacrificing their faith. (2) Muhammad's courage to the last drop of blood. (3) Sacrifice with Muhammad's martyrdom in the short story "Mauthini" by Amani Ismail. Keywords: Short Story, Palestine, Suffering, Sacrifice
Al-Shira’ Al-Siyaasiy fi Riwaayat Al-Karnak li Najib Mahfuz Wifqa Nadhariyyat Ralf Dahrendorf
Authors: Ashfiya Zaimatil , Maturedy Faris , Najwa Nafisatin 
Published: October 2023

This study aims to describe the phenomenon of politic conflict experienced by the characters in the novel al Karnak by Najib Mahfudz. Therefore, the researcher uses Ralf Dahrendorf's theory of political conflict to identify social conflicts in the novel. This study uses a qualitative method with a literature study model. Then the researcher used reading and note-taking techniques to obtain data related to social conflict in al Karnak's novel. Reading technique aims to identify politic conflict events in al Karnak's novel. While the note-taking technique aims to facilitate researchers in the process of coding for each event. After the data was obtained, data analysis was carried out using the Miles, Hubarman and Saldana model. Namely, data collection, data reduction, data presentation and drawing conclusions. The results showed that each character in the novel al Karnak wishes for a revolution in Egypt. This means that there is a strong desire to change the ideology of the state. The government, on the other hand, rejected the revolution. According to Ralf Dahrendorf's conflict theory, the government is the dominant group, while society is the dominant group. So that the government group has authority over the people
AL-HASHADU POETRY BY AHMAD MATAR (AN ANALYSIS OF RIFFATERRE’S SEMIOTICS)
Authors: Umam Muhammad Choirul , Sakinah Nyimas 
Published: October 2023

The language used in poetry is different from the use of language in general. In addition being different in usage, poetry expresses a concept and something indirectly. Language in poetry becomes a sign, which semiotics can be studied to reveal the meaning contained in it. This study examines Ahmad Matar’s poetry entitled “al-Hashadu” by using Riffaterre's semiotic theory. This research is a descriptive qualitative research. The method of data collection applied a documentation by reading and recording techniques. The technique of analyzing data used the heuristic and hermeneutic reading techniques. The results showed that: 1) The heuristic reading of al-Hashadu poetry by Aḥmad Maṭar received imperfect meaning, 2) The hermeneutic reading of al-Hashadu poetry by Aḥmad Maṭar received a complete meaning structurally, 3) The matrix of al-Hashadu poetry by Aḥmad Maṭar was the resistance to colonialism. The model of the poetry is two sentences in the stanzas "Then there will be one left" and "Truly I am an atheist" and 4) The hypogram of al-Hashadu poetry by Aḥmad Maṭar was the resistance of the Arabs to American colonialism.
SOSYAL MEDYA BAĞIMLILIĞININ VE GELİŞMELERİ KAÇIRMA KORKUSUNUN TÜKETİM DAVRANIŞLARINA ETKİLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: KURTOĞLU Elif , AYDIN Hatice 
Published: October 2023

Günümüzün en çok kullanılan iletişim aracı olan sosyal medya, zamanla sosyal hayatımız
ile bütünleşmekte ve hatta tüketim davranışlarımızı da etkileyebilmektedir. Tüketicilerin
sosyal medyaya bağımlı olması, zamanla sosyal medya korkularına dönüşebilmektedir. Bu
korkulardan birinin de gelişmeleri kaçırma korkusu olduğu düşünülmektedir. Tüketicilerin
başkalarının yaptıklarını yapma ve tükettiklerini tüketme olarak ifade edilen gelişmeleri
kaçırma korkusu ya da FoMO da zamanla tüketicilerin tüketim davranışlarını
etkileyebilmektedir. Bu çalışmada, sosyal medya bağlılığının ve sosyal medyadaki gelişmeleri
kaçırma korkusunun gösterişçi ve içgüdüsel tüketime etkisi değerlendirilmektedir. Ayrıca
sosyal medya bağımlılığının gelişmeleri kaçırma korkusuna doğrudan etkisini de
değerlendirmek amaçlanmaktadır. Çalışmada kolayda örneklem türü ile 393 katılımcıya
ulaşılmıştır. Araştırmada demografik ve tanımlayıcı analizler ile açıklayıcı faktör ve
regresyon analizleri gerçekleştirilmiştir. Elde edilen sonuçlara göre sosyal medya bağımlılığı
gelişmeleri kaçırma korkusu üzerinde ve gelişmeleri kaçırma korkusunun da tüketim üzerinde
anlamlı etkisi bulunmaktadır. Elde edilen sonuçların literatüre ve pazarlama uzmanlarına katkı
sunması beklenmektedir.
TRANSFORMASI LAYANAN INFORMASI KESEHATAN PASCA COVID-19: APLIKASI PENGINGAT DAN PENCATATAN KEGIATAN IMUNISASI ANAK DI PUSKESMAS
Authors: Wahyuni Annisa 
Published: October 2023

Pada masa pandemi Covid-19, fasilitas kesehatan memiliki tantangan tersendiri dalam percepatan pencapaian target imunisasi pada anak. Transformasi layanan kesehatan menjadi salah satu strategi untuk memberikan pelayanan lebih cepat dalam pemberitahuan informasi. Tujuan penelitian adalah mengidentifikasi masalah pelaksanaan imunisasi di masa pandemi dan menghasilkan aplikasi pengingat jadwal dan monitoring data imunisasi secara berkala pada Puskesmas. Metode penelitian adalah kualitatif, pengumpulan data melalui wawancara mendalam dan observasi. Informan penelitian meliputi pimpinan puskesmas, petugas, kader, dan orang tua. Analisis data dilakukan melalui empat tahapan yaitu pengumpulan data, reduksi dan kategorisasi data, displai data, dan penarikan kesimpulan. Hasil penelitian diketahui bahwasannya perlunya transformasi layanan kesehatan manual menuju digitalisasi, salah satunya perlu adanya pengingat jadwal dan penyampaian informasi kesehatan secara cepat dan terjangkau dengan mudah.
HUBUNGAN CYBERSEX DENGAN PERILAKU SEKSUAL PRANIKAH PADA SISWA DI SMP NEGERI X KABUPATEN BANYUWANGI
Authors: Permatadewa Elizza , Ode Taufan Asrisyah 
Published: October 2023

Remaja merupakan kelompok pengguna internet terbanyak di Indonesia. Banyak hal yang bisa dilakukan remaja ketika menggunakan internet, termasuk cybersex. Cybersex didefinisikan sebagai penggunaan internet dengan tujuan melakukan berbagai aktivitas untuk memuaskan seksual seperti melihat gambar porno, melakukan obrolan seksual, dan sebagainya. Cybersex merupakan salah satu fenomena yang berkembang dalam masyarakat modern di seluruh dunia. Pada Saat ini, fenomena tersebut telah menjadi masalah yang penting di masyarakat, terutama di kalangan generasi muda, khususnya remaja. Hal ini sangat erat hubungannya dengan perilaku seksual pranikah. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara cybersex dengan perilaku seksual pranikah pada siswa SMP Negeri X Kabupaten Banyuwangi. Jenis penelitian ini adalah kuantitatif dengan pendekatan cross sectional. Populasi penelitian ini adalah seluruh siswa SMP Negeri X Kabupaten Banyuwangi yang merupakan siswa aktif dengan jumlah 868 siswa dan jumlah sampel sebanyak 142 responden. Analisis yang digunakan dalam penelitian ini adalah univariat dan bivariat dengan menggunakan uji korelasi Kendalls tau-b. Hasil penelitian menunjukkan sebagian besar responden berjenis kelamin laki-laki (53,5%), mayoritas responden berada pada kategori remaja menengah 13–15 tahun (97,9%), sebagian besar responden melakukan cybersex pada kategori risiko rendah (84,5%) , dan perilaku seksual pranikah responden sebagian besar tergolong tidak berisiko (45,1%). Hasil uji korelasi Kendalls tau-b diperoleh nilai p (0,000), sehingga dapat disimpulkan bahwa ada hubungan antara cybersex dengan perilaku seksual pranikah pada siswa SMP Negeri X Kabupaten Banyuwangi. Berdasarkan hasil Penelitian ini disarankan agar orang tua dan guru memberikan pendidikan tentang seksualitas untuk mencegah siswa SMP melakukan cybersex dan perilaku seksual pranikah.
ANALISIS KANDUNGAN KADMIUM (Cd) DAN TIMBAL (Pb) PADA IKAN BELANAK DI WILAYAH INDUSTRI PESISIR KECAMATAN MANYAR DAN GRESIK
Authors: Romdhonia Nur Firdausa , Pujiati Rahayu Sri , Ningrum Prehatin Trirahayu 
Published: October 2023

Keberadaan industri di Kabupaten Gresik menjadi salah satu sumber pencemaran lingkungan termasuk terjadinya pencemaran perairan di Wilayah Industri Pesisir Kecamatan Manyar dan Gresik, tidak ada pembuangan khusus limbah Bahan Berbahaya Beracun (B3) menyebabkan banyaknya pengaduan terkait pembuangan limbah B3 secara liar. Jenis limbah B3 dari proses produksi dua diantaranya adalah kadmium dan timbal. Sifat logam berat yang dapat terakumulasi dalam tubuh makhluk hidup (salah satunya manusia) akan mempengaruhi kualitas hidup dan dapat menimbulkan masalah kesehatan pada rentang waktu tertentu. Tujuan adanya penelitian ini adalah untuk mengukur dan menganalisis kadar kadmium dan timbal pada ikan belanak. Penelitian ini merupakan penelitian deskriptif observasional dengan metode survei yang dilakukan di pantai utara. Pengambilan sampel dilakukan menggunakan Teknik incidental sampling pada September 2021 yang dibantu oleh nelayan setempat dengan menggunakan jaring. Kriteria sampel, ikan belanak yang tertarik pada titik sampel yang telah ditentukan, sampel ikan yang didapatkan kemudian dianalisis dengan metode Atomic Absorption Spectrometer (AAS) di salah satu laboratorium di Surabaya. Data kadar kadmium dan timbal pada ikan belanak akan dianalisis dengan menggunakan teknik analisis data univariat. Hasil uji kadar kadmium dan timbal dibandingkan dengan nilai baku mutu yang telah ditetapkan dalam Standar Nasional Indonesia 7378:2009 terkait Batas Maksimum Cemaran Logam Berat dalam Pangan. Kadar kadmium di bawah 0,1 mg/kg atau berkisar antara (-1,1663 sampai -0,0751 mg/kg) sedangkan nilai timbal berada di bawah 0,3 mg/kg atau berkisar antara (-1,2414 sampai -0,5665 mg/kg). Sehingga ikan belanak layak untuk dikonsumsi masyarakat namun tidak berlebihan. Batas maksimum yang dapat ditolelir oleh manusia dalam mengonsumsi ikan belanak dalam satu minggu untuk orang dewasa 12,5 g (setengah ekor ikan belanak ukuran sedang) dan untuk anak-anak 3.75 g (seperempat ekor ikan belanak ukuran sedang). Konsumsi kadmium pada lingkungan yang tercemar jika perhari mencapai 140-260 gram/hari dapat menyebabkan proteinuria. FAO menetapkan asupan kadmium bulanan sementara yang dapat ditoleransi pada tahun 2010 adalah sebesar 25 g/kg berat badan.
Outcome-based education in open and distance learning
Authors: Cresencio Marion 
Published: October 2023

Colleges and universities worldwide envision global excellence by providing the best education to their students. The Philippine universities started to implement outcome-based education to fulfill worldwide quality education standards. The purpose of this study is to identify the effectiveness of outcome-based education and the extent of its implementation in a Philippine university through open and distance learning. The effectiveness of outcome-based education and its extent of implementation are measured through the three identified areas such as the presentation of learning outcomes, assessment evidence and teaching and learning activities. The respondents consisted of graduate students for the academic year 2022-2023. Descriptive statistics such as the net agreement rating and the net implementation rating were used. The findings reveal a high agreement rating on the effectiveness of outcome-based education which means that there is an effective and excellent implementation of outcome-based education in open and distance learning. Meanwhile, there is a significant difference in the assessment among programs on the implementation of outcome-based education in open and distance learning. The Philippine University may sustain its effective implementation of outcome-based education and may serve as a model for other educational institutions by providing continuous support to faculty in the form of training and scholarships. These faculties are the major implementers of instructions.
Emisi Dinitrogen Oksida (N2O) pada Beberapa Metode Pengelolaan Limbah Sawah di Kecamatan Anjir
Authors: Amalia Sylvi Riska , Hadi Abdul , Septiana Meldia 
Published: October 2023

Wetlands have unique biodiversity and natural phenomena. The climate has recently changed rapidly due to greenhouse gas emissions, especially nitrous oxide from human activities such as paddy rice farming. The purpose of this study is to determine the effect of rice field waste management on the population of nitrogen-fixing bacteria and N2O emissions, and as to determine the shape and closeness of the relationship between the population of nitrogen-fixing bacteria and N2O emissions with different waste management methods. The research method used is a one-factor RGD. Close chamber technique is used for N2O emmisions analysis. The factor tested was the method of managing paddy waste before rice planting with five treatments, namely: A = Rice field waste was slashed and then lifted into the mound after a few days of being returned to the field; B = Rice field waste is carried out management slashed, rolled up, reversed and stretched; C = Rice field waste is slashed, planted with traces and then slashed again after the trace is transferred to land outside the research plot; D = Rice field waste sprayed with herbicide 2 times; E = Rice field waste sprayed with herbicide 1 time and then soil in the tractor. Each treatment was repeated four times so that 20 units of the experiment were obtained. The results showed that the method of rice field waste management carried out had no real effect on N2O emissions and nitrogen-fixing bacteria. N2O emissions not correlate with the activity of nitrogen-fixing bacteria from several methods of rice field waste management carried out
Pengaruh Kebasahan Tanah terhadap Perubahan Daya Serap Air Gambut Terbakar di Kecamatan Landasan Ulin Kalimantan Selatan
Authors: Syahbian Syahbian , Syaifuddin Syaifuddin , Haris Abdul 
Published: October 2023

Peat swamp land in Indonesia is quite extensive, which is 10.8% of Indonesia's land area, the area of peatland in Indonesia is estimated at around 14.95 million hectares, the largest on the islands of Sumatra, Kalimantan and Papua and a small part in Sulawesi. The dry process is not good can be associated with bulk density. Irreversible dryness can occur in peat with low lindak density, while peat with high lindak density is relatively easy to reabsorb water. Peat soils store much higher carbon than mineral soils. Every gr of dry peat stores about 180-600 mg of carbon, while every gr of mineral soil contains only 5-80 mg of carbon. This research method uses a descriptive exploratory method whose variable approach is carried out through land surveys and is supported by the results of soil analysis in the laboratory. The results showed the value of water content and water absorption of peat soil in the protected forest of Banjarbaru peat soil based on different times and showed a decrease in the level and absorption of peat soil.
Perubahan pH, Fe-larut, dan P-tersedia di Tanah Sulfat Masam Aktual (Sulfaquept) yang Diberi Pupuk Kandang Sapi dan Genangan Air
Authors: Soleha Noor , Priatmadi Bambang Joko , Mariana Zuraida Titin 
Published: October 2023

Organic matter application and water management were frequently applied to prevent the oxidation of pyrite in acid sulfate soils. The purpose of this study was to determine the effect of cow manure application with varying height of inundation on soil pH, soluble-Fe, and available P of acid sulfate soils. This study employed factorial treatments and in a completely randomized design. The first factor was the dosage of cow manure: 0, 10, and 20 t ha-1, while the second factor was various water depths: 5, 10, and 15 cm. Results of study showed that the interaction of cow manure and water depth did not affect soil pH, but single factor of the treatments (cow manure and water depth) significantly affected soil pH. The interaction of cow manure and water depths did not significantly decrease the solubel-Fe in the fourth week. The interaction of cow manure and water depths significantly increased P-availability in the fourth week. Results of this study demonstrated that cow manure application and water depth improved soil pH and P-availability of acid sulfate soils.
Pengaruh Variasi Kecepatan Udara dan Depth of Cut terhadap Kekasaran Permukaan pada Baja St 41
Authors: Faisal Aristya , Ansyah Pathur Razi 
Published: October 2023

Pada pembubutan konvesional, biasanya digunakan media pendingin oli yang banyak mengandung senyawa berbahaya, maka dari itu ada salah satu alternatif berupa media pendingin menggnakan kecepatan udara. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengarh variasi kecepatan udara dan kedalaman potong (depth of cut) terhadap kekasaran permukaan. Metode yang digunakan dalam penelitian ini ialah menggunakan studi eksperimen pada pembubutan pada baja ST 41. Nilai kekasaran permukaan diperoleh dari hasil pengujian kekasaran permukaan yang terbesar terdapat pada tanpa perlakan dengan kedalaman potong 1 mm 8,307 Ra dan untuk yang paling kecil terdapat pada kecepatan udara 9 m/s dengan kedalaman potong 0,5 mm 3,307 Ra. Dari hasil pengukuran kekasaran permukaan didapatkan bahwa semakin besar kedalaman potong maka nilai kekasaran permukaan semakin kasar dan begitu pula sebaliknya. Di sisi lain dengan fluktuasi kecepatan udara, semakin tinggi kecepatan udara, maka nilai kekasaran permukaan semakin halus dan begitu pula sebaliknya .Kata kunci: Pembubutan, kecepatan udara, depth of cut, kekasaran permukaan ,vortex tube
Rancang Bangun Sistem Kontrol Smart Grinder Kopi Berbasis Arduino Uno
Authors: Sinaga Gimel Hamonangan , Angka Peter R. , Gunadhi Albert , Sitepu Rasional 
Published: October 2023

Smart grinder kopi adalah sistem yang dirancang untuk tujuan meningkatkan hasil penggilingan biji kopi. Dalam artikel ini dipresentasikan hasil rancang bangun sistem kontrol smart grinder kopi yang menggunakan Arduino Uno sebagai kontroler utama. Dengan adanya Arduino Uno, pengguna diharapkan dapat mengatur tingkat kehalusan gilingan, atau jumlah kopi yang digiling dengan fitur otomatisasi berdasarkan pengukuran massa biji kopi. Sistem ini dibangun dengan komponen pokok Arduino Uno,load cell, ADC Module HX711, motor servo, push button, relay Optocoupler, dan LCD display. Smart ginder kopi berbasis Arduino Uno berhasil dibangun dan diuji. Hasil pengujian menunjukkan bahwa smart grinder kopi berbasis Arduino Uno yang dihasilkan mampu menghasilkan bubuk kopi ukuran medium sesuai timbangan yang diinginkan pengguna, dan dalam waktu rata-rata 2,5 detik per gram. Kata Kunci: smart grinder kopi, Arduino Uno, penggiling-an biji kopi, timbangan digital.
Semantic Web Services for Forest Fire Ontology’s
Authors: GUDIKANDHULA NARASIMHA RAO , Rao Peddada Jagadeeswara , Duvvuru Rajesh , Beulah Kondapalli , Lydia E. Laxmi , Rao Kundhula Bhaskara , Rathanala Prasanthi 
Published: October 2023

Abstract

Advances in space advances can ready to investigate past, the earth and various remote detecting satellites are in circle around the Earth. In this manner, Earth Observation (EO) data has been extending in size in the course of the most recent four decades and has transformed into a gainful wellspring of data for some legitimate and application spaces. Right when EO information is gotten together with different information sources many driving applications can be made. This part thinks how EO information, philosophy's, and related geospatial information can be joined for the progress of a backwoods fire noticing. The association is made to screen Kambalakonda Reserved Forest that faces the difficulties of eliminating information from EO information head-on. Earth Observation reasoning's and setting semantic comments with related geospatial information to permit the improvement of fascinating applications. web search gadgets have likewise been attempting to organize Semantic Web local people, to overhaul their understanding with GIS.