bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive finite‐time stabilizing control of fractional‐order nonlinear systems with unmodeled dynamics via sampled‐data output‐feedback
Authors: Mao Jun , Wang Ronghao , Zou Wencheng , Xiang Zhengrong 
Published: February 2024

AbstractThis article realizes an adaptive finite‐time sampled‐data output‐feedback stabilization for a class of fractional‐order nonlinear systems with unmodeled dynamics and unavailable states. K‐filters are constructed to estimate unavailable states, a dynamic signal is introduced to handle unmodeled dynamics and neural networks were used to approximate uncertain nonlinearities existed in stabilizer construction. With the help of backstepping technique, an adaptive sampled‐data output‐feedback stabilizer is exported, and such stabilizer with allowable design parameters and sampling period can render the corresponding closed‐loop system reaches practically finite‐time stable, which can be demonstrated by means of selected Lyapunov function candidates. In the end, two simulations with a numerical and an engineering examples are presented to verify the effectiveness of the proposed scheme.
A novel two‐step extrapolation‐insertion risk model based on the Expectile under the Pareto‐type distribution
Authors: Geng Ziwen 
Published: February 2024

AbstractThe catastrophe loss model developed is a challenging problem in the insurance industry. In the context of Pareto‐type distribution, measuring risk at the extreme right tail has become a major focus for academic research. The quantile and Expectile of distribution are found to be useful descriptors of its tail, in the same way as the median and mean are related to its central behavior. In this article, a novel two‐step extrapolation‐insertion method is introduced and proved its advantages of less bias and variance theoretically through asymptotic normality by modifying the existing far‐right tail numerical model using the risk measures of Expectile and Expected Shortfall (ES). In addition, another solution to obtain the ES is proposed based on the fitted extreme distribution, which is demonstrated to have superior unbiased statistical properties. Uniting these two methods provides the numerical interval upper and lower bounds for capturing the real quantile‐based ES commonly used in insurance. The numerical simulation and the empirical analysis results of Danish reinsurance claim data indicate that these methods offer high prediction accuracy in the applications of catastrophe risk management.
Design and Synthesis of Quinoline‐Pyrazine Based Carboxamides: Leukemic Cancer Active Ugi Adducts
Authors: Piludiya Reshmabanu , Kamdar Jignesh H. , Khedkar Vijay M. , Sangani Chetan B. , Saeed Waseem Sharaf , Christy Maria , Teraiya Nishith , Kapadiya Khushal 
Published: February 2024

AbstractThe design and synthesis of new chemical entities (NCEs) with suitable physicochemical properties are playing a key role in medicinal research areas. Hence, we have designed and synthesized the 10 diverse scaffolds by rightly selecting the quinoline and pyrazine to articulate carboxamide derivatives in a single‐step process with maximum conversation in a shorter time through diverse studies of Ugi multi‐component reaction. Molecular docking studies against FMS‐like tyrosine kinase‐3 (FLT3) provided well‐clustered solutions for the binding modes of these molecules and shed light on the key structural features governing the binding affinity. Two carboxamides derivatives with 3,4,5‐trimethoxy, and chloro substituents showed comparable potency in Leukemia cell lines and medium efficacy in Breast and Melanoma cancer. These results suggest that pyrazine and quinoline‐based carboxamides may be prominent as new anti‐cancer agents in chemotherapy. Additionally, in silico analysis was employed to predict the comprehensive physicochemical ADME profile (absorption, distribution, metabolism, and excretion) of the carboxamide derivatives which was proven drug‐like properties.
Carbon Molecular Sieve Membranes with Ultra‐Thin Selective Skin Layer by Pyrolysis of Porous Hollow Fibers
Authors: Sheng Lujie , Zhang Xianglong , Hua Kaisheng , Deng Maicun , Ren Jizhong 
Published: February 2024

AbstractTranslating carbon molecular sieve (CMS) membranes into highly scalable hollow fiber geometry with ultra‐thin selective layer (<1 µm) for gas separation remains as great challenge. The porous support layer of precursor hollow fiber membranes is prone to collapse during pyrolysis, which induces thick skin layer (15–50 µm) of CMS hollow fiber membranes. Here, a novel strategy is present to obtain an ultra‐thin selective skin layer by carbonization of hollow fiber membranes with porous skin. P84‐based defect‐free CMS hollow fiber membranes with ultra‐thin selective skin layer (0.9 µm) for gas separation are prepared without any coating or complex chemical pretreatment. Compared with the carbon membranes derived from defect‐free fibers, the H2 permeance (93.9 GPU) of CMS membranes derived from the porous fibers increases ≈1353% with comparable selectivity of H2/CH4 (143) and higher H2/N2 (120). Furthermore, the porous fibers are pre‐aged near the Tg in N2 conditions before carbonization, and the H2 permeance of the derived CMS hollow fiber membranes reached 147 GPU (increased 2180%). It is a new facile way to prepare CMS hollow fiber membranes with ultra‐thin selective layer by porous fibers, demonstrating its versatile potential in gas separation or organic liquids separation.
Reactive Oxygen‐Correlated Photothermal Imaging of Smart COF Nanoreactors for Monitoring Chemodynamic Sterilization and Promoting Wound Healing
Authors: Zhu Xiaohong , Feng Tiantian , Chen Yidan , Xiao Yan , Wen Wei , Wang Shengfu , Wang Dong , Zhang Xiuhua , Liang Jichao , Xiong Huayu 
Published: February 2024

AbstractChemodynamic therapy (CDT) has emerged as a promising approach for treating infected diabetic wounds, while reliable imaging technology for simultaneous monitoring of ROS and therapeutic processes is still a formidable challenge. Herein, smart covalent organic framework (COF) nanoreactors (COF NRs) are constructed by hyaluronic acid (HA) packaged glucose oxidase (GOx) covalently linked Fe‐COF for diabetic wound healing. Upon the breakdown of the HA protective layer, GOx consumes glucose to produce gluconic acid and hydrogen peroxide (H2O2), resulting in decreased local pH and H2O2 supplementation. Density functional theory (DFT) calculations show that Fe‐COF has high catalytic activity towards H2O2, leading to in situ generation of hydroxyl radicals (·OH) for sterilization, and the localized downregulation of glucose effectively improved the microenvironment of diabetic wounds. Meanwhile, based on the near‐infrared photothermal imaging of oxidized 3,3′,5,5′‐tetramethylbenzidine (oxTMB), the authors showed that TMB can be applied for the point‐of‐care testing of ·OH and glucose, and assessing the sterilization progress in vivo. More significantly, the facile photothermal signaling strategy can be extended to monitor various ROS‐mediated therapeutic systems, enabling accurate prediction of treatment outcomes.
Triple Cross‐Linking Engineering Strategies for Efficient and Stable Inverted Flexible Perovskite Solar Cells
Authors: Tu Silong , Gang Yong , Lin Yuanqiong , Liu Xinyue , Zhong Yi , Yu Daquan , Li Xin 
Published: February 2024

AbstractInverted flexible perovskite solar cells (fPSCs) are promising for commercialization due to their low cost, lightweight, and excellent stability. However, enhancing fPSCs’ power conversion efficiency and stability remains challenging. Here, an unprecedented triple cross‐linking engineering strategy is innovatively exhibit for efficient and stable inverted fPSCs. First, a carefully designed cross‐linker, 4‐fluorophenyl 5‐(1,2‐dithiolan‐3‐yl) pentanoate (FB‐TA), is added to the perovskite precursor solution. During the perovskite film's crystallization at a low temperature, the cross‐linking product of FB‐TA can passivate the grain boundaries and reduce the film's residual strain and Young's module. Then, FB‐TA is also introduced for the bottom‐ and top‐interface modification of the perovskite film. The interfacial treating strategy protects the perovskite from water invasion and strengthens the interfaces. The combination of triple strategies affords highly efficient inverted fPSCs with a champion efficiency of 21.42% among the state‐of‐the‐art inverted fPSCs based on nickel oxides. More importantly, the flexible devices also exhibit superior stabilities with T90 >4000 bending cycles, photostability with T90 >568 h, and ambient stability with T90 >2000 h, especially the stability with T80 >1120 h under harsh damp‐heat conditions (i.e., 85 °C and 85% RH). The strategy provides new insights into the industrialization of high‐performance and stable fPSCs.
Morphological Homogeneity and Interface Modification as Determinant Factors of the Efficiency and Stability for Upscaling Organic Solar Cell
Authors: Wang Tong , Zhang Jianqi , Shen Yifan , Zhang Hao , Tian Chenyang , Xie Meiling , Zhang Wenqing , Hao Xiaotao , Lu Kun , Wei Zhixiang 
Published: February 2024

AbstractMorphological homogeneity and interfacial traps are essential issues to achieve high‐efficiency and stable large‐area organic solar cells (OSCs). Herein, by the investigation of three quinoxaline‐based acceptors, i.e., PM6:Qx‐1, PM6:Qx‐2, and PM6:Qx‐p‐4Cl, the performance degradation in up‐scaling OSCs is explored. The inhomogeneous morphology in PM6:Qx‐2 induces a nonuniform spatial distribution of charge generation, showing a rapid decline in efficiency and stability in large‐area OSCs. In comparison, the homogeneous morphology in PM6:Qx‐1 and PM6:Qx‐p‐4Cl alleviates the stability drop. When utilizing 2‐phenylethylmercaptan to fill the interfacial traps, the stability drop disappears for PM6:Qx‐1 and PM6:Qx‐p‐4Cl, while it persists for PM6:Qx‐2. The PM6:Qx‐1 large‐are device yields a high efficiency of 13.47% and superior thermal stability (T80 = 2888 h). Consequently, the interface modification dominates the performance degradation of large‐area devices with homogeneous morphology, while it cannot eliminate the traps in inhomogeneous film. These results provide a clear understanding of degradation mechanisms in upscaling devices.
Enhancing conceptual models with computational capabilities: A methodical approach to executable integrative modeling
Authors: Levi‐Soskin Natali , Marwedel Stephan , Jbara Ahmad , Dori Dov 
Published: February 2024

AbstractThe lack of a common executable modeling framework that integrates systems engineering, software design, and other engineering domains is a major impediment to seamless product development processes. Our research aims to overcome this system‐software modeling gap by integrating computational, software‐related, and model execution capabilities into OPM‐based conceptual modeling, resulting in a holistic unified executable quantitative‐qualitative modeling framework. The gap is overcome via a Methodical Approach to Executable Integrative Modeling—MAXIM, an extension of OPM ISO 19450:2015, a standardization approvement given on 2015. We present the principles of MAXIM and demonstrate its operation within OPCloud—a web‐based collaborative conceptual OPM modeling framework. As a proof‐of‐concept, a model of an Airbus civil aircraft landing gear braking system is constructed and executed. Using MAXIM, engineers from five domains can collaborate at the very early phase of the system development and jointly construct a unified model that fuses qualitative and quantitative aspects of the various disciplines. This case study illustrates an important first step towards satisfying the critical and growing need to integrate systems engineering with software computations into a unified framework that enables a smooth transition from high‐level architecting to detailed, discipline‐oriented design. Such a framework is a key to agile yet robust future development of software‐intensive systems.
Genetic variance components of the growth curve for Isfahan indigenous chicken
Authors: Ghaderi‐Zefrehei Mostafa , Rafeie Farjad , Zakizadeh Sonia , Torshizi Mahdi Elahi , Peters Sunday O , Smith Jacqueline 
Published: February 2024

AbstractBackgroundBeing able to model a growth curve using three or four non‐linear functional parameters could help explain the growth phenomenon in a precise way and would allow the comparison of an animal's development rate, optimize management and feeding strategies and guide animal production strategies.ObjectiveThe goal of this study was to estimate the genetic parameters of growth traits of Isfahan indigenous chicken in Iran and to determine the best non‐linear model describing the growth curve.MethodsThe prediction of additive genetic parameters was performed using the REML method by WOMBAT. Direct heritability of the studied traits and genetic correlations between them were obtained. The Logistic, Gompertz, von Bertalanffy, Brody, Negative exponential, Weibull, Janoschek and Bridges models were compared based on the coefficient of determination (R2), mean square error (MSE) and akaike information criterion.ResultsThe Gompertz model was identified as the best model for describing the growth curve for Isfahan native chicken. The heritability of maturity weights (A), initial weight (B) and maturity rate (K) parameters were 0.223 ± 0.002, 0.016 ± 0.005 and 0.087 ± 0.001, respectively.ConclusionThis study shows that Isfahan indigenous chicken has the genetic potential for improving growth and reproduction based on their desirable heritabilities and correlations using appropriate models.
Reconstruction surgery using polypropylene mesh after extensive resection of a costal osteosarcoma in a dog
Authors: Tamura Kei , Ishigaki Kumiko , Sakurai Naoki , Heishima Tatsuya , Yoshida Orie , Asano Kazushi 
Published: February 2024

AbstractOsteosarcoma is the most common tumour that develops in the chest wall of dogs; an extensive excision is the treatment of choice. Various methods have been reported for reconstruction of chest wall defects following extensive excision.The objective of this report was to describe the complete resection of an extensive costal osteosarcoma with an extended resection of the ribs and part of the diaphragm in a dog.An 11‐year‐old neutered, male, miniature pinscher was presented with dyspnoea: An extensive mass was observed, stretching from the right chest wall to the abdominal wall. On computed tomography, the mass originated from the right 9th rib and exceeded the 6th rib on the cranial side and the 13th rib on the caudal side; it was compressing the lungs, diaphragm, liver, stomach and duodenum. When the patient's condition was medically stabilized, the tumour was removed from the right 9th rib. In consideration of the surgical margin, the 5th–13th ribs were excised, and the tumour was resected with the thoracoabdominal wall and part of the diaphragm. The missing thoracoabdominal wall and section of the diaphragm were reconstructed using two sheets of a polypropylene mesh. Postoperatively, flail chest was observed, although dyspnoea was not observed in the patient. Histopathological examination confirmed the diagnosis of osteosarcoma with a clean margin. Although 60.6 months have passed post‐surgery, no metastasis has reoccurred.In this case, complete resection and reconstruction of the chest wall and diaphragm were achieved using a polypropylene mesh without fatal postoperative complications, despite extensive osteosarcoma resection.
Diagnosis and medical treatment of portal vein thrombosis in a pet rabbit (Oryctolagus cuniculus)
Authors: Berry Alexandra , Lau Michelle , Cowan Melinda Lee 
Published: February 2024

AbstractPortal vein thrombosis is the partial or total obstruction of blood flow due to a thrombus in the hepatic portal system. This case report outlines the diagnosis and treatment of portal vein thrombosis in a rabbit. The animal presented for inappetence and lack of faecal production, and was found to have markedly elevated alanine transaminase on biochemistry. Abdominal ultrasound revealed a focal hyperechoic structure within the right intrahepatic portal venous branches, with no flow on colour Doppler interrogation. The rabbit was subsequently diagnosed with portal vein thrombosis and treated with clopidogrel and rivaroxaban. Thirty‐two days after presentation, the previously noted intrahepatic portal venous thrombus had resolved, with normal flow visualised in the portal venous branches on colour Doppler interrogation. The rabbit has remained stable for 1 year 5 months after cessation of treatment.
First report of primary tonsillar salivary gland adenocarcinoma in a dog
Authors: Murakami Keiko , Yang Ester , Carroll Jennifer , Zimmerman Kurt L. 
Published: February 2024

AbstractA 9‐year‐old, female, spayed, mixed breed dog was presented for diagnosis of adenocarcinoma of the minor salivary glands of the right tonsil by histopathology. A whole‐body computed tomography scan showed no detectable abnormalities in the major salivary glands. No pulmonary metastasis or lymphadenopathy was noted. An anaesthetised oropharyngeal examination revealed an erythematous and irregular broad‐base mass in the right tonsil, and an erythematous and slightly irregular nodular area in the contralateral tonsil. Bilateral excisional biopsies of the tonsils via tonsillectomies were performed for definitive diagnosis. Histopathology of the right tonsillar mass was consistent with an incompletely excised adenocarcinoma of the minor salivary gland, and reactive lymphoid hyperplasia of the contralateral tonsil. Based on this case report, it is important to consider salivary adenocarcinoma as a differential diagnosis for primary tonsillar tumour, as there are lobules of salivary glands in normal canine tonsils.
Reflections on the Belt and Road Initiative at Its 10th Anniversary
Authors: Yu Hong 
Published: February 2024

AbstractThe Belt and Road Initiative (BRI) reaches the 10th anniversary of implementation in 2023. In 2013, Xi Jinping, China’s President, announced the land-based “Silk Road Economic Belt” and the sea-based “Maritime Silk Road of the 21st Century” during his state visits to Kazakhstanand Indonesia, respectively.
China’s Efforts to Deepen Its Ties with the Middle Eastern Countries: The Case of Saudi Arabia and Iran
Authors: Yu Hong 
Published: February 2024

AbstractThe trip to Saudi Arabia by President Xi Jinping in December 2022 came shortly after he won a third term as China’s paramount leader at the 20th National Congress of the Chinese Communist Party in late October 2022. It also represents one of the Chinese leader’s first overseas trips for high-profile diplomacy after an almost three-year hiatus due to the global COVID-19 pandemic.
De Sitter space is sometimes not empty
Authors: Balasubramanian Vijay , Nomura Yasunori , Ugajin Tomonori 
Published: February 2024

Abstract
Multiple lines of evidence suggest that the Hilbert space of an isolated de Sitter universe is one dimensional but can appear larger when probed by a gravitating observer. To test this idea, we compute the von Neumann entropy of a field theory in a two-dimensional de Sitter universe which is entangled in a thermal-like state with the same field theory on a disjoint, asymptotically anti-de Sitter (AdS) black hole. Previously, it was shown that the replica trick for computing the entropy of such entangled gravitating systems requires the inclusion of a non-perturbative effect in quantum gravity — novel wormholes connecting the two spaces. Here we show that: (a) the expected wormholes connecting de Sitter and AdS universes exist, avoiding a no-go theorem via the presence of sources on the AdS boundary; (b) the entanglement entropy vanishes if the nominal entropy of the de Sitter cosmological horizon $$ \left({S}_{\textrm{dS}}={A}_{\textrm{horizon}}^{\textrm{dS}}/4{G}_{\textrm{N}}\right) $$

S
dS

=

A
horizon
dS

/
4

G
N

is less than the entropy of the AdS black hole horizon $$ \left({S}_{\textrm{BH}}={A}_{\textrm{horizon}}^{\textrm{AdS}}/4{G}_{\textrm{N}}\right) $$

S
BH

=

A
horizon
AdS

/
4

G
N

, i.e., SdS< SBH; (c) the entanglement entropy is finite when SdS > SBH. Thus, the de Sitter Hilbert space is effectively nontrivial only when SdS > SBH. The AdS black hole we introduce can be regarded as an “observer” for de Sitter space. In this sense, our result is a non-perturbative generalization of the recent perturbative argument that the algebra of observables on the de Sitter static patch becomes nontrivial in the presence of an observer.
Targeting disease with benzoxazoles: a comprehensive review of recent developments
Authors: Abdullahi Abdulrahman , Yeong Keng Yoon 
Published: February 2024

AbstractBenzoxazole is an attractive scaffold in medicinal chemistry due to its diverse biological applications. From 2016 to 2023, a plethora of benzoxazole derivatives have been synthesized and evaluated for their pharmacological activities but a review on this topic was found lacking. This review thus aims to fill the gap and discusses the pharmacological activities of the synthesized derivatives, emphasizing their interactions with key biological targets implicated in diseases such as cancer, diabetes, pain, inflammation, and cardiovascular disorders. Relevant works were selected mainly from databases such as PubMed and Google Scholar to offer a comprehensive overview of derivatives with promising bioactivities. The limitations pertinent to some derivatives, such as poor in vitro or in vivo activities, were highlighted, while their prospects in drug discovery was discussed.
Application of the PANELVIEW instrument to evaluate the guideline development process of the German polytrauma guideline
Authors: Goossen Käthe , Bieler Dan , Weise Alina , Nothacker Monika , Flohé Sascha , Pieper Dawid 
Published: February 2024

Abstract
Background
PANELVIEW is an instrument for evaluating the appropriateness of the process, methods, and outcome of guideline development and the satisfaction of the guideline group with these steps.

Objective
To evaluate the guideline development process of the German guideline on the treatment of patients with severe/multiple injuries (‘German polytrauma guideline’) from the perspective of the guideline group, and to identify areas where this process may be improved in the future.

Methods
We administered PANELVIEW to the participants of the 2022 update of the German polytrauma guideline. All guideline group members, including delegates of participating medical societies, steering group members, authors of guideline chapters, the chair, and methodological lead, were invited to participate. Responses were analysed using descriptive statistics. Comments received were categorised by domains/items of the tool.

Results
After the first, second, and last consensus conference, the guideline group was invited via email to participate in a web-based survey. Response rates were 36% (n/N = 13/36), 40% (12/30), and 37% (20/54), respectively. The mean scores for items ranged between 5.1 and 6.9 on a scale from 1 (fully disagree) to 7 (fully agree). Items with mean scores below 6.0 were related to (1) administration, (2) consideration of patients’ views, perspectives, values, and preferences, and (3) the discussion of research gaps and needs for future research.

Conclusion
The PANELVIEW tool showed that the guideline group was satisfied with most aspects of the guideline development process. Areas for improvement of the process were identified. Strategies to improve response rates should be explored.