bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Organ Trafficking to the Kosovo Specialist Chambers
Authors: Muharremi Robert 
Published: October 2023

Abstract
The paper discusses how strategic narratives determine our understanding of politics and justice, and how such narratives can be deliberately constructed to achieve political ends through judicial means and by instrumentalizing international criminal law and courts. The article discusses the concept of strategic narratives from an inter-disciplinary perspective and explores the impact of strategic narratives on international criminal justice. For this purpose, it analyzes as a case study the Council of Europe Parliamentary Assembly Report on “Inhuman treatment of people and illicit trafficking in human organs in Kosovo” of 2011, which led to the establishment of the Kosovo Specialist Chambers and the Kosovo Specialist Prosecutor’s Office.
Advisory Opinion on Obligations of States in Respect of Climate Change: Potential Contribution of Human Rights Bodies
Authors: McMenamin Rebecca 
Published: October 2023

Abstract
On 29 March 2023, the UN General Assembly adopted a resolution requesting an advisory opinion from the International Court of Justice on the obligations of states in respect of climate change. The icj’s opinion, if given, will be the first of an international court determining the elements of human rights obligations in the context of climate change. These issues have already been grappled with by UN human rights treaty bodies. I argue that the icj is entitled to take account of these jurisprudential developments, and should do so.
A Novel Framework for Spatiotemporal Analysis of Temperature Profiles Applied to Europe
Authors: Jamaer S. , Allaerts D. , Meyers J. , van Lipzig N. P. M. 
Published: October 2023

Abstract
Vertical temperature profiles influence the wind power generation of large offshore wind farms through stability-dependent effects such as blockage and gravity waves. However, numerical tools that are used to model these effects are often computationally too expensive to cover the large variety of atmospheric states occurring over time. Generally, an informed decision about which representative nonidealized situations to simulate is missing because of the lack of easily available information on representative vertical profiles, taking into account their spatiotemporal variability. Therefore, we present a novel framework that allows a smart selection of vertical temperature profiles. The framework consists of an improved analytical temperature model for the atmospheric boundary layer and lower troposphere, a subsequent clustering of these profiles to identify representatives, and last, a determination of areas with similar spatiotemporal characteristics of vertical profiles. When applying this framework on European ERA5 data, physically realistic representatives were identified for Europe, excluding the Mediterranean. Two or three profiles were found to be dominant for the open ocean, whereas more profiles prevail for land. Over the open ocean, weak temperature gradients in the boundary layer and a clear capping inversions are widespread, and stable profiles are absent except in the region of the East Icelandic Current. Interestingly, according to the ERA5 data, at its resolution, coastal areas and seas surrounded by land behave more similar to the land areas than to the open ocean, implying that a larger set of model integrations are needed for these areas to obtain representative results for offshore wind power assessments in comparison with the open ocean.

Significance Statement
Numerical tools used to simulate the effect of large, offshore wind farms on neighboring farms and the atmosphere are very expensive. Therefore, they can only be computed for a limited number of cases. As temperature is one of the most important parameters in these kinds of simulations, this work provides a new vertical temperature model and an analysis framework that allows for a smart selection of these cases such that they ideally represent the full variation of the atmosphere’s temperature profiles.
On the Role of Wind–Evaporation–SST Feedbacks in the Subseasonal Variability of the East Pacific ITCZ
Authors: Ganguly Indrani , Gonzalez Alex O. , Karnauskas Kristopher B. 
Published: October 2023

Abstract
The intertropical convergence zone (ITCZ) is a zonally elongated band of near-surface convergence and precipitation near the equator. During boreal spring, the eastern Pacific ITCZ migrates latitudinally on daily to subseasonal time scales, and climate models exhibit the greatest ITCZ biases during this time of the year. In this work, we investigate the air–sea interactions associated with the variability in the eastern Pacific ITCZ’s latitudinal location for consecutive days when the ITCZ is only located north of the equator (nITCZ events) compared to when the ITCZ is on both sides of the equator or south of the equator (dsITCZ events) during February–April. The distribution of sea surface temperature (SST) anomalies and surface latent heat flux (SLHF) anomalies during the nITCZ and dsITCZ events follow the classic wind–evaporation–SST (WES) positive feedback mechanism. However, an alternative mechanism, embracing the effect of SST anomalies on vertical stratification and momentum mixing, gives rise to a negative WES feedback. Our results show that in the surface layer, there is a general progression of positive WES feedbacks happening in the weeks leading to the events followed by negative WES feedbacks occurring after the ITCZ events, with an alternate mechanism involving air–sea humidity differences limiting evaporation occurring in between. Additionally, the spatial structures of the components of the feedbacks are nearly mirror images for these opposite ITCZ events over the east Pacific during boreal spring. In closing, we find that understanding the air–sea interactions during daily to weekly varying ITCZ events (nITCZ and dsITCZ) helps to pinpoint how fundamental processes differ for ITCZs in different hemispheres.
Prediction of Clausius–Clapeyron Scaling of Daily Precipitation Extremes over China
Authors: Chen Wenhui , Cui Huijuan , Zheng Jingyun 
Published: October 2023

Abstract
Observations and model simulations have confirmed that the higher percentiles of precipitation intensity of all wet days have increased with the local daily dewpoint temperature at the Clausius–Clapeyron (C-C) rate of 7% °C−1 using the binning technique over China. It is uncertain whether the binning scaling rates will remain constant in the future climate. Here, we use daily precipitation and dewpoint temperature (DPT) over China from 20 CMIP6 models to examine and project the change of binning scaling of precipitation extremes. The results of the study suggest that the multimodel ensemble median (MEM) generally captures the spatial distribution of binning scaling rates and binning curves in different climate zones across China. The binning scaling rates have stability in the future but with a large increasing trend (more than 30%) in southeast China in the far future (2061–2100) under the SSP5-8.5 scenario. CMIP6 models project that both the peak of extreme precipitation and the temperature for the plateau mountain zone will increase in the far future under the SSP5-8.5 scenario, implying that the peak structure does not provide an upper limit for future precipitation extremes.

Significance Statement
The binning scaling rates describe the relationship between precipitation extremes and temperature based on their day-to-day variations. However, it is still unclear whether the binning scaling rates of daily precipitation extremes with daily temperature will change in the future. We use 20 CMIP6 models to project the scaling rates of precipitation extremes with dewpoint temperature over China in the future. The results show that the sensitivity of precipitation extremes to dewpoint temperature will generally be stable, except that southeast China shows an increasing trend of up to 30%. Moreover, the peak of extreme precipitation and the temperature will increase with warming in the plateau mountain zone. Our results have implications for precipitation prediction and risk assessment.
A computational study of leading-edge wall cooling effect on shock wave–boundary layer interaction in forward-facing step
Authors: P Vinoth Kumar , Murugan Jayaprakash N 
Published: October 2023

A computational study has been done to understand the effect of leading-edge wall cooling on shock wave–boundary layer interaction. Shock wave–boundary layer interaction is studied over a forward-facing step at supersonic Mach 2.5. The study was carried out using Ansys. The work aims to explore the implementation of wall cooling at the leading edge as a separation control strategy for supersonic forward-facing step-induced flow separation. We use a finite-volume method based on upwind flux difference splitting and second-order upwind flow discretization. The simulation results are validated with the available experimental data. Furthermore, using numerical simulations, we found that the separation bubble size was reduced by 18.36% when the walls were marginally cooled to 150 K, while the separation was reduced by 32.65% when the walls were strongly cooled to 100 K.
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle
Authors: Chen Xubo , Xiang Weiren , Li Lihua , Xu Kai 
Published: October 2023

Antioxidant 1 copper chaperone (Atox1) may contribute to preventing DDP cochlear damage by regulating copper transport family and cell cycle proteins. A rat model of cochlear damage was developed by placing gelatin sponges treated with DDP in the cochlea. HEI-OC1 cells were treated with 133 μM DDP as a cell model. DDP-induced ototoxicity in rats was confirmed by immunofluorescence (IF) imaging. The damage of DDP to HEI-OC1 cells was assessed by using CCK-8, TUNEL, and flow cytometry. The relationship between Atox1, a member of the copper transport protein family, and the damage to in vivo/ vitro models was explored by qRT-PCR, western blot, CCK-8, TUNEL, and flow cytometry. DDP had toxic and other side effects causing cochlear damage and promoted HEI-OC1 cell apoptosis and cell cycle arrest. The over-expression of Atox1 (oe-Atox1) was accomplished by transfecting lentiviral vectors into in vitro/ vivo models. We found that oe-Atox1 increased the levels of Atox1, copper transporter 1 (CTR1), and SOD3 in HEI-OC1 cells and decreased the expression levels of ATPase copper transporting α (ATP7A) and ATPase copper transporting β (ATP7B). In addition, the transfection of oe-Atox1 decreased cell apoptosis rate and the number of G2/M stage cells. Similarly, the expression of myosin VI and phalloidin of cochlea cells in vivo decreased. Atox1 ameliorated DDP-induced damage to HEI-OC1 cells or rats' cochlea by regulating the levels of members of the copper transport family.
New forceps free injection technique for delivering descemet membrane endothelial keratoplasty preloaded endothelium-in grafts
Authors: Gadhvi Kunal A. , Pagano Luca , Wallace Alexander , Posarelli Matteo , Parekh Mohit , Romano Vito 
Published: October 2023

Purpose To describe a new method for delivering DMEK grafts into the recipient's eye with endothelium inward configuration using a no-forceps injection technique Methods We retrospectively review 11 patients that underwent DMEK surgery at our institution using a no-forceps injection technique. The graft was preloaded into an intraocular lens (IOL) cartridge and connected to an anterior chamber maintainer (ACM). A 5 ml non luer lock syringe was inserted into the other end of the ACM to create a one-flow system. The cartridge was inserted into the posterior end of an injector, and the graft was successfully delivered into the recipient's eye. Result Twelve eyes of 11 patients were included. Mean follow-up was 9.16 ± 1.3 months. At baseline, mean best corrected visual acuity (BCVA) was 0.76 ± 0.13 logMAr and mean endothelial cell density (ECD) was 2619.00 ± 115.89 cells/mm2. At follow-up, BCVA significantly improved to 0.22 ± 0.05 logMAR ( p = 0.003). Although we observed a significant reduction in ECD at follow-up (1688 ± 182.20, p = 0.002), our patients lost only 35.69 ± 6.36% of endothelial cells. Conclusion Our technique can help surgeons safely deliver an endothelium-in graft into the recipient's eye. The method doesn’t require the use of a forceps, minimizing the risk of endothelial cell loss or graft damage.
Case report: Relapsed disseminated cutaneous herpes zoster successfully treated with brivudine
Authors: Feng Mengdi , Zhang Jinfang , Zhang Guoqiang 
Published: October 2023

A 64-year-old man presented with painful rash on the trunk and extremities for more than half a month. Nephrotic syndrome had been diagnosed 2 years ago and had been regularly treated with glucocorticoids and immunosuppressants. He developed herpes zoster 1 year ago. Laboratory investigation demonstrated varicella-zoster virus DNA (VZV-DNA), varicella-zoster virus IgM (VZV-IgM), and varicella-zoster virus antibody IgG (VZV-IgG) were all positive. After the clinical diagnosis of relapsed disseminated cutaneous herpes zoster had been confirmed, systemic therapy with brivudine 125 mg everyday was started.
Healthcare resource utilisation and economic burden attributable to back pain in primary care: A matched case-control study in the United Kingdom
Authors: Zemedikun Dawit T , Kigozi Jesse , Wynne-Jones Gwenllian , Guariglia Alessandra , Nirantharakumar Krishnarajah , Marshall Tom , Roberts Tracy 
Published: October 2023

Objective Incremental healthcare costs attributed to back pain, and characterisation by patient and clinical factors have rarely been documented. This study aimed to assess annual healthcare resource utilisation and costs associated with back pain in primary care. Methods Using the IQVIA Medical Research Data (IMRD), patients with back pain were identified (study period: 01 January 2006 to 31 December 2015) using diagnostic records and analgesics prescriptions ( n = 133,341), and propensity score matched 1:1 to patients without back pain. The annual incremental costs of back pain associated with consultations and prescriptions were estimated and extrapolated to a national level. Sensitivity analysis was conducted by restricting the study population to the most recent diagnosis of back pain. Variations in cost were assessed stratified by gender, age-groups, deprivation, and comorbidity categories. Results The mean age was 57 years, and 62% were females in both the case and control groups. The total incremental healthcare costs associated with back pain was £32.5 million in 2015 (£35.9 million in 2020), with per-patient cost of £244 (£265 in 2020) per year. On a national level, this translated to an estimated £3.2 billion (£3.5 billion in 2020). Eighty percent of the costs were attributed to consultations; and female gender, older age, higher deprivation, and higher comorbidity were all associated with increased mean healthcare costs of patients with back pain. Conclusion Our findings confirm the substantial healthcare costs attributed to back pain, even with primacy care costs only. The data also revealed significant cost variations across socio-demographic and clinical factors.
Examining the Effect of Income-Based Inequalities and Dental Service Provision on Dental Service Utilization among Older Australians: A Multiple Mediation Analysis
Authors: Ghanbarzadegan A. , Sohn W. , Wallace J. , Brennan D.S. , Jamieson L.M. 
Published: October 2023

Introduction: Public service provision is one of the keys to reducing inequalities in the utilization of dental services. Given the increase in the aging population, there should be a focus on older adults’ oral health. However, this is often overlooked. Objectives: This study investigates the effectiveness of public services in reducing income-related inequalities in dental service utilization among older South Australians. Methods: A multiple counterfactual mediation analysis using the ratio of mediator probability weighting approach was used to explore the proposed mediation mechanism using a South Australian population of older adults (≥65 y). The exposure variable in the analysis was income, and the mediators were concession cards and the last dental sector (public or private). The outcome variable was the time of last dental visit. Results: Half of the older adults with high income (≥$40,000) owned a concession card, and 10% of those who attended public dental services belonged to this group. Interestingly, only 16.3% of the study participants had visited the public dental sector at their last dental appointment. Results showed a negligible indirect effect (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.85–1.05) and a significant direct effect (OR, 3.09; 95% CI, 2.24–4.87). By changing the potential outcome distributions to the counterfactual exposure distributions and taking the mediators’ distribution as a counterfactual exposure distribution, the odds of dental visits occurring before the past 12 mo approximately tripled for low-income compared to high-income individuals. Conclusion: Income inequalities were associated with relatively delayed dental visits in older South Australians, and provision of public services could not improve this pattern. This might happen due to inequitable access to concession cards and public services. A review of policies is required, including addressing income inequalities and implementing short-term approaches to improve service utilization patterns in older South Australians. Knowledge Transfer Statement: The findings of this study can enable policymakers for informed decision-making about the provision of public dental services for older Australians. This study emphasizes the importance of reviewing the current public dental services and subsidies and implementing short-term approaches to reduce income inequalities for older Australians.
Mini-Invasive Harvesting of Quadriceps Tendon Graft With Patellar Bone Block for ACL Reconstruction Using a Dedicated Harvester
Authors: Vittone Giulio , Valcarenghi Jérôme , Mouton Caroline , Seil Romain 
Published: October 2023

Background: The selection of the type of graft used to reconstruct the anterior cruciate ligament (ACL) remains a matter of debate. In the past, the quadriceps tendon (QT) was associated with considerable morbidity and less favorable outcomes than other grafts. Improvements in harvesting methods have decreased morbidity of the surgical procedure and led to an increase in the use of QT in recent years. Indications: The QT graft with patellar bone block is a viable option for all patients with closed physis undergoing ACL reconstruction. It is especially suitable for young and active patients who practice activities that require kneeling or athletes in which hamstrings preservation is advisable. Technique Description: A vertical mini-invasive longitudinal incision starts 1 cm proximal to the middle of the patellar pole. After dissection, the bone block is marked and detached with an oscillating saw. A drill hole is performed in the bone block to serve for the passage of a traction suture. The bone block is lifted with the help of the traction suture, and the graft is trimmed to the desired diameter. The layer between tendon and capsule is separated by blunt dissection to spare the capsule of the suprapatellar pouch. Harvesting is achieved using a dedicated QT harvester. Usually, a graft length of 8 cm is harvested. The defect in the QT is closed using a suture passer at the proximal end. Finally, the graft is prepared and calibrated according to the planned technique for ACL reconstruction. Results: There was no major intraoperative complication in the senior author's series (more than 50 patients) using the dedicated QT harvester. On rare occasions (<10% of the cases), the device opened the suprapatellar joint capsule, creating the additional need for capsular repair during defect closure. On two occasions, the graft was shorter than expected, which may have been caused by insufficient dissection or improper use of the harvester. Discussion/Conclusion: ACL reconstruction with minimally invasive QT graft harvesting methods has shown very good clinical outcomes with few complications. It can be recommended for primary and revision ACL reconstruction. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Lithofacies, stratigraphy and depositional history of Middle Muschelkalk evaporites (Zeglingen Formation) in northern Switzerland
Authors: Pietsch Johannes S. , Wetzel Andreas , Deplazes Gaudenz , Filipponi Marco 
Published: October 2023

AbstractIn northern Switzerland, Middle Muschelkalk evaporites (Zeglingen Formation) were deposited under arid conditions in the southernmost part of the epicontinental Central European Basin during times of reduced inflow of sea water from the Tethyan realm. Because of their marginal position in the basin, direct and detailed correlation of Muschelkalk sediments of northern Switzerland with equivalent strata in interior parts of the basin is not straightforward. Based on detailed sedimentological logging of 640 m of drill cores from ten wells in northern Switzerland, 22 lithofacies and 10 lithofacies associations were distinguished for the Middle Muschelkalk evaporites. High-resolution regional correlations of gamma-ray logs record substantial thickness variation of the evaporites. Locally, dissolution was recognized by visual core examination that could be dated to Middle Triassic times and that was likely related to subsurface fluid flow along deeper seated faults. In combination with the regional thickness variation, the dissolution phenomena suggest a tectonically active depositional setting in the Middle Triassic. Middle Muschelkalk evaporites consist of nine types of mainly auto-cyclic shallowing- or brining-upward mini-cycles which form a correlatable succession of five distinct 4th order cycle-sets. Despite the tectonically active depositional environment, most lithofacies encountered appear to have nearly flat bounding surfaces. Thus, marine transgressions flooded wide areas nearly simultaneously. The corresponding deposits serve as reference levels to tie the peripheral facies of northern Switzerland into the supra-regional context.