bluuebunny/crossref_metadata_2025_split huggingface dataset:
Icaritin Sensitizes Thrombin- and TxA2-Induced Platelet Activation and Promotes Hemostasis via Enhancing PLCγ2-PKC Signaling Pathways
Authors: Zhu Zhixiang , Luo Yanggan , Liao Hanjing , Guo Ran , Hao Doudou , Lu Zihan , Huang Manjing , Sun Chenghong , Yao Jingchun , Wei Ning , Zeng Kewu , Tu Pengfei , Zhang Guimin 
Published: January 2024

Background Vascular injury results in uncontrollable hemorrhage in hemorrhagic diseases and excessive antithrombotic therapy. Safe and efficient hemostatic agents which can be orally administered are urgently needed. Platelets play indispensable roles in hemostasis, but there is no drug exerting hemostatic effects through enhancing platelet function.
Methods The regulatory effects of icaritin, a natural compound isolated from Herba Epimedii, on the dense granule release, thromboxane A2 (TxA2) synthesis, α-granule release, activation of integrin αIIbβ3, and aggregation of platelets induced by multiple agonists were investigated. The effects of icaritin on tail vein bleeding times of warfarin-treated mice were also evaluated. Furthermore, we investigated the underlying mechanisms by which icaritin exerted its pharmacological effects.
Results Icaritin alone did not activate platelets, but significantly potentiated the dense granule release, α-granule release, activation of integrin αIIbβ3, and aggregation of platelets induced by thrombin and U46619. Icaritin also shortened tail vein bleeding times of mice treated with warfarin. In addition, phosphorylated proteome analysis, immunoblotting analysis, and pharmacological research revealed that icaritin sensitized the activation of phospholipase Cγ2 (PLCγ2)-protein kinase C (PKC) signaling pathways, which play important roles in platelet activation.
Conclusion Icaritin can sensitize platelet activation induced by thrombin and TxA2 through enhancing the activation of PLCγ2-PKC signaling pathways and promote hemostasis, and has potential to be developed into a novel orally deliverable therapeutic agent for hemorrhages.
Alpha-Thalassemia X-Linked Intellectual Disability Syndrome in a Boy with a Strong Family History of Smith–Lemli–Opitz's Syndrome
Authors: Jafar Bedour , Sharma Kamal P. , Maertens Paul 
Published: January 2024

AbstractAlpha-thalassemia X-linked intellectual disability (ATRX) syndrome is a rare disorder characterized by facial dysmorphism, genitourinary tract abnormalities, alpha-thalassemia, and cognitive impairment. Patients present in early infancy with hypotonia, microcephaly, failure to thrive, and delayed milestones. We report a boy with strong family history of the Smith–Lemli–Opitz's syndrome (SLOS) phenotype. All affected family members displayed facial features and presentation identical to those of our patient. None had hypocholesterolemia. All affected family members were boys and have died. Molecular genetic testing in our patient revealed a likely pathogenic mutation in the X-linked recessive ATRX gene. We conclude that SLOS and ATRX syndrome are uncommon disorders sharing similar manifestations. Awareness of such similarity should prompt physicians to explore the possibility of ATRX syndrome in relatives of patients with unproven SLOS.
Structural and functional analysis of Buchanan’s constitutional contract
Authors: Liu Mingyu 
Published: January 2024

AbstractBuchanan attempted to seek new theoretical construction through the contract method by introducing elements such as ‘individual’, ‘veil of uncertainty’, ‘public choice’, ‘decision costs’, and ‘unanimous agreement principle’. He not only transformed the contract theory model but also interpreted the ideas of consensus politics in an acceptable manner. Specifically, ‘individuals’ are entities of choice and behavior, and the process of choice allows individuals to express different goals and interests. The ‘veil of uncertainty’ prompts individuals to think about issues from a fair point of view when interests cannot be identified and future prospects are unpredictable and to make choices that are beneficial for both themselves and the group. ‘Public choice’ can solve the problem of justice diversity because it does not exclude different or conflicting motivations and goals. ‘Decision costs’ and ‘external costs’ both limit the way collective decisions are made and help identify the normal consequences of constitutional choices. The ‘unanimous agreement principle’ gives everyone equal status, allowing each person the right to pursue their own goals and values and preventing others from abusing their power. The use of the aforementioned theoretical elements not only helps people discuss constitutional choices at a general level but also helps to present the true face of the collective decision-making process, thereby establishing an empirical theory about the actual logic of individual actions in the political system.
Fully-vertical GaN-on-SiC Schottky barrier diode with ultrathin AlGaN buffer layer
Authors: Sun Yuting , Feng Yuxia , Wei Jia , Wang Maojun , Yang Xuelin , Mei Wenkang , Yang Yufei , Shen Bo 
Published: January 2024

Abstract
In this letter, vertically conductive GaN epilayer on SiC substrate was achieved without the typically used conductive buffer layer. Here, in order to reduce the impacts of band offset of different layers on vertical conductivity and improve the vertical carrier transportation, an ultrathin AlGaN buffer layer was employed to replace the thick conductive buffer layer. Fully-vertical Schottky barrier diode (SBD) based on this vertically conductive epi-stack demonstrated a much lower specific on-resistance of 0.84 mΩ·cm2 with superior thermal stability. Moreover, the SBD also exhibited an on/off ratio of ∼5 × 109 and a nearly unity ideality factor of 1.08. This approach lays the foundation for the heterogeneous integration of GaN/SiC based devices.
Study of Type-B QPOs Observed in Black Hole X-Ray Binary Swift J1728.9-3613
Authors: Kumar Raj 
Published: January 2024

Abstract
We report the detection of type-B quasi-periodic oscillation (QPO) of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst. A type-B QPO was observed for the first two days and it disappeared as flux increased, but again appeared at ∼7.70 Hz when flux was dramatically decreased. The source was found in the soft intermediate state during these observations. We further studied the energy dependence of the QPO. We found that QPO was observed only for a higher energy range implying that the origin of QPO is possibly due to the corona emitting higher energy photons by the inverse Compton process. The variation of spectral parameters can be explained with the disk truncation model. The fractional rms was found to be monotonically increased with energy. The phase lag spectrum followed the “U-shaped” curve. The rms and phase lag spectrum are modeled and explained with the single-component Comptonization model vkompthdk.
First operation of an ACHINOS-equipped spherical proportional counter with individual anode read-out
Authors: Herd D. , Katsioulas I. , Knights P. , Manthos I. , Matthews J. , Millins L. , Neep T. , Nikolopoulos K. , Rogers G. 
Published: January 2024

Abstract
The multi-anode sensor ACHINOS revolutionised the capabilities of the spherical proportional counter by enabling large-size, high-pressure, operation and TPC-like reconstruction capabilities through individual anode read-out.
First measurements with an individually read out ACHINOS are performed, which enables improved calibration and response homogenisation. Experimental results demonstrating the improvement in energy resolution brought by the individual anode calibration are presented. These are complemented by detailed simulation studies on the effect of sensor design and manufacturing imperfections, and how they may be corrected both in hardware and analysis.
Computing electronic correlation energies using linear depth quantum circuits
Authors: Chee Chong Hian , Mak Adrian M , Leykam Daniel , Kl Barkoutsos Panagiotis , Angelakis Dimitris G 
Published: January 2024

Abstract
Efficient computation of molecular energies is an exciting application of quantum computing for quantum chemistry, but current noisy intermediate-scale quantum (NISQ) devices can only execute shallow circuits, limiting existing variational quantum algorithms, which require deep entangling quantum circuit ansatzes to capture correlations, to small molecules. Here we demonstrate a variational NISQ-friendly algorithm that generates a set of Hartree–Fock ansatzes using multiple shallow circuits with depth linear in the number of qubits to estimate electronic correlation energies via perturbation theory up to the second order. We tested the algorithm on several small molecules, both with classical simulations including noise models and on cloud quantum processors, showing that it not only reproduces the equilibrium molecular energies but it also captures the perturbative electronic correlation effects at longer bond distances. The number of shallow circuits required for our algorithms scales

O
(

N
5

)

, with N being the system size, thus enabling the study of larger molecules compared to other approaches, where circuit depth or number of qubits required become prohibitive for NISQ devices.
Efficient quantum simulation of nonlinear interactions using SNAP and Rabi gates
Authors: Park Kimin , Marek Petr , Filip Radim 
Published: January 2024

Abstract
Quantum simulations provide means to probe challenging problems within controllable quantum systems. However, implementing or simulating deep-strong nonlinear couplings between bosonic oscillators on physical platforms remains a challenge. We present a deterministic simulation technique that efficiently and accurately models nonlinear bosonic dynamics. This technique alternates between tunable Rabi and SNAP gates, both of which are available on experimental platforms such as trapped ions and superconducting circuits. Our proposed simulation method facilitates high-fidelity modeling of phenomena that emerge from higher-order bosonic interactions, with an exponential reduction in resource usage compared to other techniques. We demonstrate the potential of our technique by accurately reproducing key phenomena and other distinctive characteristics of ideal nonlinear optomechanical systems. Our technique serves as a valuable tool for simulating complex quantum interactions, simultaneously paving the way for new capabilities in quantum computing through the use of hybrid qubit-oscillator systems.
Breast Reconstruction Using the Extended Latissimus Dorsi Myocutaneous Flap—A Long-term Follow-up Utilizing BREAST-Q
Authors: Wyckman Alexander , Assareh Armin , Steinvall Ingrid , Zdolsek Johann 
Published: January 2024

Abstract

Background
The latissimus dorsi (LD) flap is a commonly used method for breast reconstruction after mastectomy. In this study, we present a long-term follow-up and effects of refining surgery on patient satisfaction and quality of life after breast reconstruction with the extended LD flap, using the BREAST-Q questionnaire.

Objectives
The aim of this study was to investigate the patient-reported long-term results after breast reconstruction with the extended LD myocutaneous flap.

Methods
A retrospective cohort study of adult patients (n = 101) who were operated on using the extended LD flap for breast reconstruction at the Linköping University Hospital during 1997 to 2012 was made using data retrieved from medical records. The patients were asked to complete the BREAST-Q questionnaire at 2 different postoperative time points.

Results
Eighty-three patients replied to the first questionnaire, and 56 patients also replied to the second. Mean follow-up was 11.7 years. Higher age and living together with someone correlated to higher BREAST-Q results, while postoperative infection, bilateral LD flaps, smoking, and prior breast surgery had a negative impact on the results. Overall BREAST-Q results increased over time. No independent effect of refining surgery could be shown.

Conclusions
Patient satisfaction after breast reconstruction with the LD flap as measured with the BREAST-Q questionnaire is high and in line with other studies. The overall satisfaction with the reconstruction method seems to increase with time, but no further increase in satisfaction after refining surgery could be established.

Level of Evidence: 3
Imaging chronic active lesions in multiple sclerosis: a consensus statement
Authors: Bagnato Francesca , Sati Pascal , Hemond Christopher C , Elliott Colm , Gauthier Susan A , Harrison Daniel M , Mainero Caterina , Oh Jiwon , Pitt David , Shinohara Russell T , Smith Seth A , Trapp Bruce , Azevedo Christina J , Calabresi Peter A , Henry Roland G , Laule Cornelia , Ontaneda Daniel , Rooney William D , Sicotte Nancy L , Reich Daniel S , Absinta Martina 
Published: January 2024

Abstract
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with multiple sclerosis, in vivo.
Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted and T2-weighted scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL. While partially overlapping, these biomarkers do not have equivalent sensitivity and specificity to histopathological CAL. Standardization in the use of available imaging measures for CAL identification, quantification and monitoring is lacking.
To fast-forward clinical translation of CAL, the North American Imaging in Multiple Sclerosis Cooperative developed a consensus statement, which provides guidance for the radiological definition and measurement of CAL. The proposed manuscript presents this consensus statement, summarizes the multistep process leading to it, and identifies the remaining major gaps in knowledge.
Surface-mediated dynamic cooperative motions in azobenzene polymer films
Authors: Seki Takahiro 
Published: January 2024

Abstract
Azobenzene (1,2-diphenyldiazene in IUPAC name) is a widely studied, simple, rodlike photochromic molecule. The trans- (E) to cis- (Z) photoisomerization of this molecule was discovered a long time ago (nearly 90 yr). Nevertheless, the allure and utility of this molecule never faded and it has not surrendered a leading position among many other organic photochromic molecules. New applications for photoswitching molecular and macromolecular systems are still being proposed extensively. By linking the azobenzene molecule to liquid crystals (LCs) and polymer systems, a number of fascinating motility functions have been newly realized. This article overviews our research activities using azobenzene-containing monolayers and LC polymer films. The topics range across surface photoalignment of LCs, both from solid surface and free surface; photoalignment of hierarchical structures such as mesohybrids and block copolymers; photomechanical motions and morphological switching in block copolymer monolayers; high-density brushes of azobenzene side chain LC polymers (SCLCPs); photo-triggered mass migrations in azobenzene SCLCP films; and polymer motions via Marangoni flow, etc. Demonstrations of these dynamic photofunctions are expected to provide great opportunities for practical smart applications.
Construction of multi-ring molecules through direct C-H bond transformation
Authors: Nishii Yuji , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: January 2024

Abstract
Transition metal-catalyzed aromatic functionalization reactions are highly important for the construction of various organic fine chemicals. In particular, the direct C(sp2)-H bond transformation of (hetero)aromatics is currently recognized to be highly useful in organic synthesis, as it can realize short-step sequences leading to target molecules. We have been studying aromatic cross-coupling reactions through C-H bond activation/cleavage leading to new C-C and C-heteroatom bonds. The research strategies involve directing group (DG) control and utilization of unique properties of reaction substrates and catalysts, which enable efficient regioselective direct coupling reactions. In this account, our recent work is briefly summarized, mainly focused on the synthetic methods of benzo-fused multi-ring heterocyclic compounds of potent interest in pharmaceutical and material chemistry.
Density-functional tight-binding molecular dynamics study on fixation reaction of CO2 to styrene oxide catalyzed by Mg-MOF-74 metal-organic framework
Authors: Chou Chien-Pin , Sakti Aditya Wibawa , Tsuchiya Yuta , Sekine Yasushi , Nakai Hiromi 
Published: January 2024

Abstract
Carbon capture and utilization is a strategy to reduce CO2 emissions by utilizing them to synthesize fine chemicals. Mg-MOF-74 exhibits exceptional CO2 adsorption capacity and functions as a catalyst in styrene carbonate synthesis from CO2 and styrene oxide. We examined the structural properties and energetics of styrene carbonate synthesis in Mg-MOF-74 at the third-order density-functional tight-binding level. A novel reaction mechanism via the formation of a seven-membered ring intermediate was found to exhibit a lower Gibbs activation energy than the previously proposed mechanism.
Long-term conservation tillage with reduced nitrogen fertilization intensity can improve winter wheat health via positive plant–microorganism feedback in the rhizosphere
Authors: Behr Jan Helge , Kuhl-Nagel Theresa , Sommermann Loreen , Moradtalab Narges , Chowdhury Soumitra Paul , Schloter Michael , Windisch Saskia , Schellenberg Ingo , Maccario Lorrie , Sørensen Søren J , Rothballer Michael , Geistlinger Joerg , Smalla Kornelia , Ludewig Uwe , Neumann Günter , Grosch Rita , Babin Doreen 
Published: January 2024

Abstract
Microbiome-based solutions are regarded key for sustainable agroecosystems. However, it is unclear how agricultural practices affect the rhizosphere microbiome, plant–microorganism interactions and crop performance under field conditions. Therefore, we installed root observation windows in a winter wheat field cultivated either under long-term mouldboard plough (MP) or cultivator tillage (CT). Each tillage practice was also compared at two nitrogen (N) fertilization intensities, intensive (recommended N-supply with pesticides/growth regulators) or extensive (reduced N-supply, no fungicides/growth regulators). Shoot biomass, root exudates and rhizosphere metabolites, physiological stress indicators, and gene expression were analyzed together with the rhizosphere microbiome (bacterial/archaeal 16S rRNA gene, fungal ITS amplicon, and shotgun metagenome sequencing) shortly before flowering. Compared to MP, the rhizosphere of CT winter wheat contained more primary and secondary metabolites, especially benzoxazinoid derivatives. Potential copiotrophic and plant-beneficial taxa (e.g. Bacillus, Devosia, and Trichoderma) as well as functional genes (e.g. siderophore production, trehalose synthase, and ACC deaminase) were enriched in the CT rhizosphere, suggesting that tillage affected belowground plant–microorganism interactions. In addition, physiological stress markers were suppressed in CT winter wheat compared to MP. In summary, tillage practice was a major driver of crop performance, root deposits, and rhizosphere microbiome interactions, while the N-fertilization intensity was also relevant, but less important.
Examination of Hibiscus sabdariffa’s bioactive arsenal: pharmacological prospects and comprehensive insights into catalysing health and wellness through its therapeutic attributes—an exposition
Authors: Bhandare Saurabh Dilip , Malode Sarika Shivaji 
Published: January 2024

Abstract
This study signifies the rich pharmacological potential of Hibiscus sabdariffa, exploring its bioactive components and their therapeutic implications for health and wellness. Despite the promising insights, a comprehensive critical analysis is essential to ensure scientific rigour. To address this, the study establishes clear aims and objectives, aiming to scrutinise the study findings through a meticulous assessment. In conclusion, this study, upon addressing these key points, aspires to offer a robust contribution to scientific research, by advancing the understanding of H. sabdariffa’s therapeutic attributes and promoting the adoption of sustainable methodologies in scientific research.
Rapid, economical diagnostic classification of ATRT molecular subgroup using NanoString nCounter platform
Authors: Ho Ben , Arnoldo Anthony , Zhong Yvonne , Lu Mei , Torchia Jonathon , Yao Fupan , Hawkins Cynthia , Huang Annie 
Published: January 2024

Abstract

Background
Despite genomic simplicity, recent studies have reported at least 3 major atypical teratoid rhabdoid tumor (ATRT) subgroups with distinct molecular and clinical features. Reliable ATRT subgrouping in clinical settings remains challenging due to a lack of suitable biological markers, sample rarity, and the relatively high cost of conventional subgrouping methods. This study aimed to develop a reliable ATRT molecular stratification method to implement in clinical settings.

Methods
We have developed an ATRT subgroup predictor assay using a custom genes panel for the NanoString nCounter System and a flexible machine learning classifier package. Seventy-one ATRT primary tumors with matching gene expression array and NanoString data were used to construct a multi-algorithms ensemble classifier. Additional validation was performed using an independent gene expression array against the independently generated dataset. We also analyzed 11 extra-cranial rhabdoid tumors with our classifier and compared our approach against DNA methylation classification to evaluate the result consistency with existing methods.

Results
We have demonstrated that our novel ensemble classifier has an overall average of 93.6% accuracy in the validation dataset, and a striking 98.9% accuracy was achieved with the high-prediction score samples. Using our classifier, all analyzed extra-cranial rhabdoid tumors are classified as MYC subgroups. Compared with the DNA methylation classification, the results show high agreement, with 84.5% concordance and up to 95.8% concordance for high-confidence predictions.

Conclusions
Here we present a rapid, cost-effective, and accurate ATRT subgrouping assay applicable for clinical use.