bluuebunny/crossref_metadata_2025_split huggingface dataset:
A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools
Authors: Morey-León Gabriel , Mejía-Ponce Paulina M. , Granda Pardo Juan Carlos , Muñoz-Mawyin Karen , Fernández-Cadena Juan Carlos , García-Moreira Evelyn , Andrade-Molina Derly , Licona-Cassani Cuauhtémoc , Berná Luisa 
Published: December 2023

Introduction
Tuberculosis (TB) is among the deadliest diseases worldwide, and its impact is mainly due to the continuous emergence of resistant isolates during treatment due to the laborious process of resistance diagnosis, nonadherence to treatment and circulation of previously resistant isolates of Mycobacterium tuberculosis. In this study, we evaluated the performance and functionalities of web-based tools, including Mykrobe, TB-profiler, PhyResSE, KvarQ, and SAM-TB, for detecting resistance in 88 Ecuadorian isolates of Mycobacterium tuberculosis drug susceptibility tested previously. Statistical analysis was used to determine the correlation between genomic and phenotypic analysis. Our results showed that with the exception of KvarQ, all tools had the highest correlation with the conventional drug susceptibility test (DST) for global resistance detection (98% agreement and 0.941 Cohen’s kappa), while SAM-TB, PhyResSE, TB-profiler and Mykrobe had better correlations with DST for first-line drug analysis individually. We also identified that in our study, only 50% of mutations characterized by the web-based tools in the rpoB, katG, embB, pncA, gyrA and rrs regions were canonical and included in the World Health Organization (WHO) catalogue. Our findings suggest that SAM-TB, PhyResSE, TB-profiler and Mykrobe were efficient in determining canonical resistance-related mutations, but more analysis is needed to improve second-line detection. Improving surveillance programs using whole-genome sequencing tools for first-line drugs, MDR-TB and XDR-TB is essential to understand the molecular epidemiology of TB in Ecuador.

Importance
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, most commonly affects the lungs and is often spread through the air when infected people cough, sneeze, or spit. However, despite the existence of effective drug treatment, patient adherence, long duration of treatment, and late diagnosis have reduced the effectiveness of therapy and increased drug resistance. The increase in resistant cases, added to the impact of the COVID-19 pandemic, has highlighted the importance of implementing efficient and timely diagnostic methodologies worldwide. The significance of our research is in evaluating and identifying a more efficient and user-friendly web-based tool to characterize resistance in Mycobacterium tuberculosis by whole-genome sequencing, which will allow more routine application to improve TB strain surveillance programs locally.
Antenatal care booked rural residence women have home delivery during the era of COVID-19 pandemic in Gidan District, Ethiopia
Authors: Asmamaw Desale Bihonegn , Habitu Yohannes Ayanaw , Mekonnen Eskedar Getie , Negash Wubshet Debebe 
Published: December 2023

Background
World Health Organization (WHO) recommends that every pregnant woman receive quality care throughout pregnancy, childbirth, and the postnatal period. It is estimated that institutional delivery could reduce 16% to 33% of maternal deaths. Despite the importance of giving birth at a health institution, in Ethiopia, according to the Ethiopian Demographic Health Survey report, nearly half of the ANC-booked mothers gave birth at home. Therefore, this study aimed to determine the prevalence and associated factors of home delivery among antenatal care-booked women in their last pregnancy during the era of COVID-19.

Methods
A community-based cross-sectional study was conducted from March 30 to April 29, 2021. A simple random technique was employed to select 770 participants among women booked for antenatal care. Interviewer-administered questionnaires were used to collect the data. A binary logistic regression model was fitted. Adjusted odds ratios with its respective 95% confidence interval were used to declare the associated factors.

Results
The prevalence of home delivery was 28.8% (95% CI: 25.7, 32.2). Rural residence (AOR = 2.02, 95% CI: 1.23, 3.34), unmarried women (AOR = 11.16, 95% CI: 4.18, 29.79), husband education (AOR = 2.60, 95% CI: 1.72, 3.91), not being involved in the women’s development army (AOR = 1.64, 95% CI: 1.01, 2.65), and fear of COVID-19 infection (AOR = 3.86, 95% CI: 2.31, 6.44) were significantly associated factors of home delivery.

Conclusion
Even though the government tried to lower the rate of home delivery by accessing health institutions in remote areas, implementing a women’s development army, and introducing maternal waiting home utilization, nearly one in every three pregnant women gave birth at home among ANC booked women in their last pregnancy. Thus, improving the husband’s educational status, providing information related to health institution delivery benefits during antenatal care, and strengthening the implementation of the women’s development army, particularly among rural and unmarried women, would decrease home childbirth practices.
Infâncias, cuidado, liberdade, pertencimento
Authors: Tiriba Lea , Guimarães Mauro 
Published: December 2023

Em meio à crise ambiental planetária, radicalizamos movimentos de busca de referências conceituais que nos apontem alternativas civilizatórias e indiquem pistas teórico-práticas para o desmonte do modelo escolar eurocêntrico, referenciado no capitalismo colonialista que devasta a Terra. Atento a modos de conceber a existência em conexão com o cosmos, este ensaio se volta para povos originários brasileiros, interessado em perceber o lugar das crianças na organização de suas sociedades e nos processos de constituição de sujeitos coletivos. O conhecimento é fruto de revisão bibliográfica, visitas a aldeias e diálogo com lideranças indígenas. As análises se apoiam na filosofia espinosana, em epistemes nativas, em estudos dos campos da antropologia da criança, da educação infantil e da educação ambiental crítica.
Crystal structure of aqua-(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ
4
N,N′,N″,N‴)copper(II) 5-carboxyisophthalate tetrahydrate, C25H50N4CuO11
Authors: Quan Qin-Guo , Ou Guang-Chuan 
Published: December 2023

Abstract
C25H50N4CuO11, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 10.553(6) Å, b = 12.099(7) Å, c = 12.674(8) Å, α = 86.258(6)°, β = 78.131(6)°, γ = 81.408(6)°, V = 1564.8(16) Å3, Z = 2, R

gt
(F) = 0.0332, wR

ref
(F
2) = 0.0927, T = 296(2) K.
The crystal structure of (E)-4-chloro-N′-(1-(4-hydroxyphenyl)propylidene)benzohydrazide, C16H15ClN2O2
Authors: Wang Yanjiao , Wang Chao , Gao Xuguang , Liu Bin 
Published: December 2023

Abstract
C16H15ClN2O2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.9715(8) Å, b = 8.2727(8) Å, c = 11.5105(12) Å, α = 90.296(8)°, β = 100.566(9)°, γ = 102.603(9)°, V = 727.41(13) Å3, Z = 2, Rgt
(F) = 0.0522, wRref
(F
2) = 0.1257, T = 293 K.
Clinical significance of CYP11B2 immunostaining in unilateral primary aldosteronism
Authors: Viukari Marianna , Leijon Helena , Vesterinen Tiina , Söderlund Sanni , Hämäläinen Päivi , Yliaska Iina , Rautiainen Päivi , Rintamäki Reeta , Soinio Minna , Pörsti Ilkka , Nevalainen Pasi I , Matikainen Niina 
Published: December 2023

Objective
The associations between adrenal histopathology, lateralization studies, and surgical outcomes in primary aldosteronism remain poorly characterized. We examined the value of immunohistochemical analysis of CYP11B2 for evaluation of adrenalectomy outcomes after anatomical versus functional subtyping.

Design
A retrospective multicenter study of 277 patients operated for primary aldosteronism who had an adrenalectomy sample available in the Finnish biobanks from 1 January 2000 to 31 December 2019. Adrenal slides from biobanks were analyzed centrally after CYP11B2 and CYP11B1 staining. Clinical data were obtained from patient registries. Histopathological diagnosis and cure after surgery were assessed as outcome measures.

Results
Re-evaluation with CYP11B2 staining changed the histopathological diagnosis in 91 patients (33%). The presence of a CYP11B2-positive adenoma and the use of functional subtyping independently predicted clinical cure of primary aldosteronism. CYP11B2-positive <7 mm nodules were more frequent in patients without clinical cure, whereas CYP11B2-positive micronodules were common in all patients and had no impact on adrenalectomy outcomes. Small CYP11B2-positive nodules and micronodules were equally prevalent regardless of the subtyping method applied. Clinical cure rates were lower and CYP11B2-negative adenomas more common after adrenalectomy based on anatomical imaging than functional studies.

Conclusions
Incorporating CYP11B2 staining in histopathological diagnosis enhances the prediction of surgical outcomes in primary aldosteronism. A finding of CYP11B2-positive adenoma is indicative of cure of primary aldosteronism, whereas smaller CYP11B2-positive nodules associate with poorer results at postoperative evaluation. Functional subtyping methods decrease the operations of CYP11B2-negative adenomas and are superior to anatomical imaging in identifying unilateral primary aldosteronism.
ПІДГОТОВКА МАЙБУТНІХ ФАХІВЦІВ ПРОФЕСІЙНОГО ТИПУ «ЛЮДИНА – ЛЮДИНА» ДО МІЖОСОБОВОГО СПІЛКУВАННЯ ЗАСОБАМИ УКРАЇНСЬКОГО МОВНОГО ЕТИКЕТУ
Authors: KUZENKO ОLEXANDRA , MATSUK LIUDMYLA , ADAMIV MARIA 
Published: December 2023

Стаття присвячена проблемам підготовки майбутніх фахівців професійного типу «людина-людина» до міжособовго спілкування. Авторами обгрунтовується значення міжособового спілкування в реалізації професійних завдань фахівців у галузі освіти та охорони здоров’я. Акцентується на гуманістичній спрямованості міжособового спілкування та значенні українського мовного етикету у формуванні їх професійної готовності до ефективної комунікації.
РЕАЛІЗАЦІЯ МІЖПРЕДМЕТНИХ ЗВ’ЯЗКІВ МІЖ ДИСЦИПЛІНАМИ ПРИРОДНИЧОГО ЦИКЛУ У ПРОЄКТНІЙ ДІЯЛЬНОСТІ УЧНІВ ОСНОВНОЇ ШКОЛИ ЯК ОСНОВИ КОМПЕТЕНТНІСНОГО НАВЧАННЯ ФІЗИКИ
Authors: KOROSTELOVA YEVHENIIA 
Published: December 2023

У статті ставиться завдання відображення результатів обробки та аналізу експериментальних даних напрацювання науково-природничої і математичної компетентності учнями основної школи при використанні міжпредметних зв’язків фізики з дисциплінами природничого циклу в проєктній діяльності.
На основі статистичного аналізу отриманих результатів усі чотири сформульовані гіпотези приймаються з високим рівнем надійності, а саме:
1) до проведення формувального експерименту контрольна та експериментальна групи були однорідними за рівнями сформованості досліджуваних компетентностей;
2) після проведення експерименту рівні сформованості досліджуваних компетентностей в контрольній групі не зазнали суттєвих структурних змін;
3) після проведення експерименту рівні сформованості досліджуваних компетентностей в експериментальній групі змінились суттєво;
4) після проведення формувального експерименту контрольна та експериментальна групи суттєво відрізняються за високим і низьким рівнями сформованості досліджуваних компетентностей.
Las vertientes externa e interna del imperialismo cultural: una crítica a Edward Said
Authors: BENZAL Emma 
Published: December 2023

Las principales obras de Edward Said, Orientalismo y Cultura e Imperialismo, definen lo que en este artículo se denomina vertiente externa del imperialismo cultural. Se critica que al no prestar atención a la vertiente interna, se invisibilizan y naturalizan dimensiones muy importantes de la cultura. Y al reflexionar sobre la estos aspectos que se olvidan, se obtiene una visión completa del papel de la cultura que resulta reveladora al entender el mundo de hoy en día.
"Estudiar el estado" en State in Society: Studying How States and Societies Transform and Constitute One Another, Cambridge Studies in Comparative Politics, Cambridge University Press, Cambridge, 2001
Authors: MIGDAL Joe S. 
Published: December 2023

A lo largo del siglo XX los asuntos centrales para los politólogos dedicados a la política comparada han cambiado muy poco. Desde Weber y Gramsci hasta Almond, Verba o Skocpol, sus preocupaciones se han centrado en por qué la gente obedece y qué tipo de estructuras y culturas facilitan la obediencia y el comportamiento conformista. Los elementos que los politólogos han singularizado en sus investigaciones como las claves para comprender la obediencia y la conformidad han incluido a los sospechosos habituales: los parlamentos, las burocracias, el liderazgo gubernamental, los tribunales y las leyes, y la policía y los militares. Estos forman las partes constitutivas y los parámetros de la estructura compleja y de alguna manera escurridiza a la que llamamos estado moderno —la montaña que tarde o temprano todos los politólogos tienen que escalar—.
Zoonotic Staphylococcus spp. among domestic animals in Ukraine: antibiotic resistance and diagnostic approaches
Authors: Shevchenko M. , Andriichuk A. , Naumchuk V. , Petruk I. , Bilyk S. , Tsarenko T. 
Published: December 2023

Staphylococcus pseudintermedius and S. aureus are common infectious agents with zoonotic potential, capable of acquiring antibiotic resistance and causing hospital-acquired infections. This study aimed to assess the prevalence of S. pseudintermedius among dogs in Ukraine and explore the possibility of using chromogenic media for accurate identification and differentiation of S. aureus and S. pseudintermedius. The data obtained indicate a higher prevalence of nasal carriage (44.8%) of Staphylococcus spp. in healthy dogs compared to ear carriage (28.5%). Among the isolated strains in nasal swabs, S. pseudintermedius was most often detected (24.1%), S. aureus was detected less often (5.2%). Among the samples taken from sick dogs, 36.5% were found to be Staphylococcus spp., of which 20.5% contained S. pseudintermedius and 4.5% S. aureus. Among the studied cats, 36.8% were found to contain Staphylococcus spp., S. pseudintermedius – 10.5%, and S. aureus – 5.3%. Antibiotic resistance profiles were different: S. pseudintermedius was resistant to the combination of trimethoprim-sulfamethoxazole, as well as to penicillin and erythromycin, while S. aureus was resistant to penicillin. It should be noted that only one coagulase-positive S. aureus isolate obtained from healthy animals was resistant to oxacillin. The use of chromogenic media demonstrated the possibility of successful differentiation of S. aureus and S. pseudintermedius based on differences in culture properties. In addition, various combinations of microbiological tests were evaluated, resulting in the development of two schemes that included specific media and additional reactions to improve identification accuracy. The combination of CHROMagar™ Orientation with the coagulase detection reaction demonstrated higher sensitivity (100%) for the detection of S. pseudintermedius compared to the combination of mannitol salt agar (MSA) with the coagulase detection reaction (75%). In addition, the PCR reaction was valuable for the definitive identification of coagulase-positive staphylococci (CoPS). These comprehensive results shed light on the prevalence, species distribution, antibiotic resistance patterns, and diagnostic approaches for S. aureus in dogs and cats in Ukraine, emphasizing the importance of developing reliable surveillance and control strategies.
Estimación de parámetros en modelos Rasch para la estimación de inseguridad alimentaria en una población.
Authors: Rodriguez de España Maria , Ramoni-Perazzi Josefa , Orlandoni-Merli Giampaolo 
Published: December 2023

Introducción: The Food Insecurity Experience Scale es una propuesta metodológica del Proyecto Voices of the Hungry de la División de Estadística de FAO; es un conjunto de preguntas cuyo objetivo es la medición de inseguridad alimentaria como rasgo latente. Este módulo de preguntas puede ser incluido en una encuesta y con la matriz de respuesta puede calcularse prevalencias de inseguridad alimentaria a través de un modelo de Rasch usando la suma de las respuestas afirmativas obtenidas por una persona a las preguntas del módulo FIES como un estadístico suficiente para la estimación del rasgo latente: Inseguridad alimentaria. Materiales y Métodos: Se simuló en R una matriz de respuestas al módulo FIES posteriormente se aplicó un modelo de Rasch a esta matriz de respuesta con el fin de obtener los parámetros theta y beta según distintos marcos inferenciales : máxima verosimilitud, bayesiana, marginal y condicional, para la estimación se usaron distintos paquetes R. Resultados y Discusión: La estimación de los parámetros según la estimación por máxima verosimilitud y condicional no son apropiadas para estimar los puntajes extremos Conclusiones: La estimación bayesiana y la marginal sí logran estimar los puntajes extremos en los parámetros sin embargo, tiene costo computacional alto. La estimación condicional, que es la estimación actualmente usada en el protocolo analítico de la escala FIES a nivel global , requiere el uso de pseudo puntajes para estimar los y y es la estimación recomendada si se requiere estimar la severidad del rasgo latente en individuos o hogares.
IMPROVING UNDER-RESOURCED SECONDARY SCHOOL TEACHERS’ LITERACY INSTRUCTION: AN INTERVENTIONAL ETHNOGRAPHIC STUDY
Authors: Wirza Yanty , Gunawan Wawan , Setyaningsih Anita T , Ramdani Sarah A , Hanipah Hanipah , Aufa Fellia L. , Edelweis Sherly L.B. 
Published: December 2023

The study is a part of the government-sponsored literacy program to improve the Indonesian secondary students’ literacy performance. Particularly, this study focuses on the examination of the program as the attempt to improve the secondary teachers’ literacy instruction at the under-resourced schools. The program implemented in the Bahasa Indonesia subject by employing Reading to Learn pedagogy (Rose, 2016) in teaching the explanatory text. Using an interventional ethnographic study design, which involves three main phases i.e. Reading to Learn pedagogy workshop, the R2L implementation with mentoring, and evaluation, the current study investigates the experience of two female eighth graders’ contract-based teachers, in their early thirties, at two under-resourced secondary schools in, Bandung, West Java, Indonesia. The data collected in this three-month study were observation, interviews with the teachers, principal, and students, recorded teaching sessions, recorded reflections sessions, and lesson plans and teaching materials. The findings of the study reveal that the teachers’ literacy instruction in utilizing stages in the R2L pedagogy indicated significant improvement from their previous practice. The intensive mentoring provided during the workshop and school implementation of the R2L implementation have equipped the teachers with more solid pedagogical foundation in internalizing and implementing the R2L pedagogy. In addition, the program has promoted the teachers’ professional development and assisted the school to gain larger access to literacy pedagogy for better literacy participation.
MULTIMODAL REPRESENTATIONS ACROSS SCIENTIFIC GENRES: PERSPECTIVES FROM SCIENCE TEACHERS' PRACTICES
Authors: Padios Alfredo , Pascua Sarah , Orleans Antriman 
Published: December 2023

Multimodal representations have caught science education researchers’ attention due to its immense role in meaning making. While much have been written about this area of research, the interplay between multimodal representations and scientific genres in classrooms is yet to be fully explored.The purpose of this study is to examine multimodal representations across scientific genres from the viewpoints of science teachers. With Filipino science teachers as respondents, we employed a sequential explanatory mixed methods research design to determine the frequency of occurrence of scientific genres in classrooms as well as the frequency of use of multimodal representations across each scientific genre. First, we administered the questionnaire, analyzed the result then conducted a follow-up interview to determine how and why scientific genres and multimodal representations are utilized. Results revealed that information report and explanation are the genres most utilized by science teachers primarily because they conform to curriculum standards and that these support students’ learning and skills. On the other hand, experimental account and argument genres are used less often largely due to lack of available materials and teacher competence. Across these genres, linguistic-verbal, visual-graphical and gestural-kinesthetic representations are “always” used while material-operational and mathematical-symbolic are used to a lesser extent. More importantly, this study confirms again that science teaching is multimodal mainly to address each student learning needs and make meaning making thus, science learning, easier. Important implications to practice and research are discussed.
The early generation of Yanggongju (Western Princess) and their life polemics in 1950-1955
Authors: Widyana Ashanti , Fianita Fina , Megasari Jayanti 
Published: December 2023

Yanggongju, the sexual workers for G.I. soldiers who were stationed in Korea particularly during and after Korean war, were stigmatized as 'bad women' for having sexual relationships out of marriage with foreign men. These women must endure hardships that came from the clients or the pimps in daily basis. This study aims to investigate how the life and polemics yanggongju had experienced in the period of 1950-1955. The early generations of yanggongju consisted of women with various backgrounds, such as war widows and women who became the breadwinner of the family. This study used qualitative method and the data were collected from the articles of Kyunghyang Shinmun, Dong-a Ilbo, and Chosun Ilbo in the period of January 1, 1950, to December 31, 1555, accessed from a news archive site called naver news library. After two-times process of data reduction, 47 articles were collected under the category of nyu-seu (news). It was found that the early generation of yanggongju experienced at least four kinds of polemics in their life: (1) life difficulties (physically and mentally), such as fallen women stigma, vulnerable to sexual transmitting disease, and having many debts, (2) child neglect in the form of attempted abortion and child abandonment, (3) suicide and abused, and (4) alcohol and drug (opium) addiction. It is hoped that this research can contribute to further researches on the problem of yanggongju and their position as a marginalized people.
여기까지: Korean as a foreign language learning fossilization among adult Filipinos
Authors: Galang Aljon Delmo 
Published: December 2023

Language fossilization happens when learners do not progress anymore in certain features of the target language, especially in interlanguage learning context. this investigation sought to answer the following research questions: (a) What are the linguistic features in Korean language that the KFL Filipino learner participants are fossilized in? (b) Why do they arrive at such state of fossilization?. The qualitative study used narrative approach to identify the linguistic features that the KFL Filipino learner participants are fossilized in, and the reasons behind such language phenomenon, based on their learning narratives. There were twelve (12) KFL Filipino learners who participated in the study. Their narratives on KFL learning were analyzed, coded, and arranged to identify these fossilizations and the reasons behind. Findings reveal that the KFL (a) fossilizations are in sound-character correspondence, orthographical-phonological metamorphosis, language syntax, verb conjugation and suffixation in context, and vocabulary difficulty and (b) the reasons of fossilization are weak memory, language disorder, Hangeul character resemblance and subtle differences, differences of L1 and L2 sentence patterns to Korean language syntax, lack of interest on sources of language exposure, discourse opportunities with Korean language speakers, and fear of language use due to uncertainty. These results contribute to improvement of foreign language instruction.