bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival outcomes of robot-assisted transmediastinal esophagectomy in patients with esophageal squamous cell carcinoma
Authors: Yagi Koichi , Aikou Susumu , Yajima Shoh , Urabe Masayuki , Sato Yasuyohi , Okumura Yasuhiro , Mitsui Takashi , Nishida Masato , Yamagata Yukinori , Yamashita Hiroharu , Nomura Sachiyo , Mori Kazuhiko , Seto Yasuyuki 
Published: January 2025

Summary
We developed a robot-assisted transmediastinal esophagectomy (RATME) to reduce the surgical invasiveness of open transthoracic esophagectomy (oTTE). However, the long-term survival outcomes of patients who undergo RATME remain unclear. Patients who underwent RATME for esophageal squamous cell carcinoma (ESCC) between January 2012 and April 2020 were enrolled. Overall survival (OS), relapse-free survival (RFS), and ESCC cause-specific survival (CSS) were analyzed according to clinical stage. Survivals were compared between patients who underwent the RATME and oTTE using propensity score matching analysis. One hundred and twenty-seven patients who underwent RATME were included in the analysis. The 3- and 5-year OS rates were 96.2 and 92.1% for cStage I RATME group, 84.8 and 82.3% for cStage II, and 61.8 and 61.8% for cStage III, respectively. The 3- and 5-year RFS rates were 94.3 and 84.3% for cStageI, 71.7 and 69.3% for cStage II, and 5 48.2 and 48.2% for cStage III, respectively. Survival analysis using 74 paired patients showed that the RATME group had better OS and RFS than the oTTE group (p = 0.0028 and p = 0.016, respectively), but equivalent CSS (p = 0.078). The OS of the RATME group stratified by clinical stage was equivalent to that of the comprehensive registry data from Japan, and showed better OS and RFS than the oTTE group, indicating that RATME radicality is guaranteed with regard to long-term survival.
Prevalence and prognostic impact of ST-segment elevation in lead aVR among patients with cardiac arrest
Authors: Banna Soumya , Schenck Christopher , Kim Noah , Ali Tariq , Gilmore Emily J , Greer David M , Beekman Rachel , Miller P Elliott 
Published: January 2025

Abstract

Aims
In acute coronary syndrome, ST-segment elevation in lead aVR (STE-aVR) indicates global myocardial ischaemia, often related to multivessel or severe left main disease, and correlates with increased mortality. The prevalence and prognostic significance of STE-aVR in cardiac arrest (CA) patients is unknown.

Methods and results
We identified patients (≥18 years) with CA between 2011 and 2022 who achieved return of spontaneous circulation (ROSC). The first electrocardiogram post-ROSC was assessed for STE-aVR, defined as ≥1 mm ST-segment elevation at the J point, measured by two trained assessors. Multivariable logistic regression was used to analyse the association between STE-aVR and outcomes (in-hospital mortality and poor neurologic outcome), adjusted for patient and arrest characteristics. Including 443 CA patients, the median (interquartile range) age was 61 years (50–72 years), with 60.5% (n = 268) male, 65.7% (n = 291) presenting with out-of-hospital CA (OHCA), and 29.8% (n = 132) with shockable rhythms. ST-segment elevation in lead aVR was observed in 18.3% (n = 81) of patients. Those with STE-aVR were more likely to present with OHCA and less likely to have a shockable rhythm (both, P &lt; 0.05). ST-segment elevation in lead aVR was associated with higher in-hospital mortality (86.4% vs. 65.8%, P &lt; 0.001) and poor neurologic outcomes (90.1% vs. 72.9%, P = 0.001). After multivariable adjustment, STE-aVR remained associated with higher in-hospital mortality [odds ratio (OR) 2.23; 95% confidence interval (CI): 1.02–4.84, P = 0.04], but not a poor neurologic outcome (OR 2.12; 95% CI: 0.90–4.98, P = 0.09).

Conclusion
ST-segment elevation in lead aVR was present in one in five CA survivors and was independently associated with higher in-hospital mortality.
Aortic valve repair in adults: long-term clinical outcomes and echocardiographic evolution in different valve repair techniques
Authors: Zito Francesco , Veen Kevin M , Melina Giovanni , Lansac Emmanuel , Schäfers Hans-Joachim , de Kerchove Laurent , Takkenberg Johanna J M , Kluin Jolanda , Mokhles M Mostafa 
Published: January 2025

Abstract

Objective
Aortic valve repair/sparing have been established as effective treatments for aortic regurgitation and/or aortic aneurysms. However, concerns remain regarding long-term durability, reproducibility, and patient selection. This study aims to asses long-term clinical and echocardiographic outcomes, with a focus on aortic regurgitation grade and left ventricular ejection fraction evolution, in adults undergoing these procedures.

Methods
Adult patients in the Heart Valve Society Aortic Valve Database, undergoing any aortic valve repair/sparing technique were included. Time-to-event analyses were used for clinical outcomes and mixed-effects-models for left ventricular ejection fraction and aortic regurgitation evolution. Techniques: isolated valve repair (GROUP-1), ascending aortic replacement +valve repair (GROUP-2), partial-root replacement +/-valve repair (GROUP-3), and valve-sparing root replacement +/-valve repair (GROUP-4).

Results
Survival at 10-years was comparable to the general population in each group. The 10-year cumulative incidence of reintervention was 19.5%(95%CI:16.70-22.40%) in GROUP-1 [Including only double external annuloplasty in GROUP-1, reintervention was not significantly different between techniques (p = 0.112)], 13.8% (95%CI: 10.10-18.10%) in GROUP-2, 12.7%(95%CI:5.50-22.90%) in GROUP-3, and 8.5%(95%CI:7.00-10.10%) in GROUP-4 (p &lt; 0.001). Severe preoperative aortic regurgitation grade [HR: 1.95(95%CI:1.19–3.21),p&lt;0.001] and left ventricular end-diastolic diameter [HR:1.03(95%CI:1.00–1.05),p&lt;0.001] were predictive of reintervention in GROUP-4, patch use was a predictor in all groups. Predicted left ventricular ejection fraction (%) initially increased(p &lt; 0.001) and then stabilized.

Conclusion
This study found that aortic valve repair/sparing techniques provide a viable and effective treatment option that should be considered for all eligible patients with aortic regurgitation and/or aortic root/ascending aortic aneurysms, given their potential to restore life expectancy and provide good hemodynamic outcomes with an acceptable hazard of reintervention.
Ross procedure for aortic regurgitation versus stenosis in adults with and without autograft support
Authors: Abeln Karen B , Froede Lennart , Ehrlich Tristan , Souko Idriss , Schäfers Hans-Joachim 
Published: January 2025

Abstract

OBJECTIVES
The Ross procedure for aortic regurgitation (AR) and abnormal aortic valve morphologies is associated with an increased risk of autograft dilatation. Autograft support may ameliorate this problem. We analyzed the results for all haemodynamic lesions and the effect of autograft support.

METHODS
A retrospective analysis was conducted of patients who underwent a Ross procedure at Saarland University Medical Center between December 1995 and December 2023. (315 patients undergoing full-root replacement with or without autograft support). Twenty-three (7%) were younger than 18 years and were excluded. The cohort was divided into 3 groups: Patients with aortic stenosis (AS), AR, and combined disease (CD). Endpoints included survival, freedom from reoperation and AR, and aortic root dimensions; these were compared between the three groups. Median follow-up was 3.6[range 0.01–26.6] and 95% complete.

RESULTS
Overall, 292 adult patients (male 74%; mean age 39 years(SD : 10) were analyzed with (n = 209) or without autograft support (n = 83). Patients with AS (n = 79; 28%) were compared to those with AR (n = 77; 25%) and those with CD (n = 136; 50%). Valve morphology was unicuspid (n = 141; 48%), bicuspid (n = 109; 38%), or tricuspid (n = 42; 14%). Survival at 15 years was similar across the groups (AR 86%; AS 93%; CD 94%; p = 0.123). Freedom from autograft reoperation was 90% at 10 years (AR 80%; AS 95%; CD 92%; p = 0.009). With autograft support, it was 93% at 10 years (AR 90%; AS 93%; CD 95%; p = 0.179). Neither UAV (HR 1.072; 95% CI 0.34–3.43; p = 0.907) nor BAV (HR 0.102; 95% CI 0.08–1.26; p = 0.102) were associated with reoperation.

CONCLUSIONS
Patients with AR and an unsupported root replacement do have an increased risk of reintervention, irrespective of aortic valve morphology. With autograft support, however, autograft stability is excellent, irrespective of the underlying lesion. Thus, the Ross procedure in its supported version can be offered to all haemodynamic types and valve morphologies.
Oedema index trajectories at heart failure nurse clinics over 6 months after acute heart failure predict patient outcomes: a retrospective cohort study
Authors: Liu Min-Hui , Wang Chao-Hung , Ye Shu-Ling , Lin Mei-Hui , Wang Cai-Ping , Yang Ning-I 
Published: January 2025

Abstract

Aims
Fluid accumulation is associated with poor outcomes in patients with heart failure (HF). After acute HF, HF nurses provide home care suggestions based on oedema status assessed at outpatient clinics. However, the pattern of serial oedema changes and their associations with patient outcomes are unknown. We investigated the trajectories of bioimpedance analysis (BIA)–derived oedema index (EI) changes following acute HF and their prognostic value.

Methods and results
This was a retrospective cohort study. We recruited 761 patients hospitalized for HF. Multisegmented and multifrequency BIA-derived EIs were measured at HF nurse outpatient clinics after discharge for 6 months. We explored the trajectories of EIs and their associations with all-cause rehospitalization and death within 2 years. Four EI trajectories were identified: trajectory 1 [T1, no oedema, n = 181 (23.8%)], T2 [transient, n = 341 (44.8%)], T3 [fluctuation, n = 195 (25.6%)], and T4 [worsening, n = 44 (5.8%)]. Compared with the T1 group, the T3 and T4 groups included more females; were older; had higher natriuretic peptide and glycohaemoglobin levels; and had higher incidences of comorbidities but lower albumin and cholesterol and worse kidney function (all P &lt; 0.05). The Kaplan–Meier survival curves showed that T2, T3, and T4 patients had lower event-free survival rates than did T1 patients (all P &lt; 0.01). Multivariable analysis demonstrated that T3 and T4 were independently associated with an increased risk for events (P &lt; 0.001).

Conclusion
During the 6-month outpatient period after hospitalization, the EI trajectory of fluctuation or worsening was associated with poor outcomes. In the post-acute phase, monitoring the EI trajectory helps identify high-risk patients for optimizing HF management.
The influence of temperature on courtship and mate choice in a wolf spider: implications for mating success in variable environments
Authors: Rosenthal Malcolm F , Elias Damian O 
Published: January 2025

Abstract
The selection of animal signal form often changes significantly with the environment, yet signal form may be environment-dependent. Little is known about how variation in individual responses to changing environments affects the relationship between selection and the subsequent evolution of signal traits. To address this question, we assess the effects of variation in temperature on individual signaling and mating behavior responses across temperatures in the wolf spider Schizocosa floridana. By running repeated-measures trials, we find that temperature has predictable effects on signal form, but that the performance of individual courters is not consistent across temperatures. Traits associated with courtship rate generally increase at higher temperatures but inter-individual consistency in response to temperature change is low, despite consistent female preferences for increased courtship rate at all temperatures. Interestingly, the production of the likely most recently evolved signal component, the chirp, is consistent within signalers and predicts male performance across temperatures. Despite this, female preferences for chirp duration appear only at higher temperatures. Taken together, our results suggest that individual courter responses to changing temperatures have the potential to dampen or eliminate patterns of selection that are evident across temperatures. We discuss these results in light of current research on mating behavior and sexual selection.
A TTPA deletion is associated with retinopathy with vitamin E deficiency in the English Cocker Spaniel dog
Authors: Oliver James A C , Stanbury Katherine , Schofield Ellen , McLaughlin Bryan , Mellersh Cathryn S 
Published: January 2025

Abstract
Retinopathy with vitamin E deficiency is a familial disease in the English Cocker Spaniel dog breed. Ophthalmic abnormalities observed in retinopathy with vitamin E deficiency-affected English Cocker Spaniel include lipofuscin granule deposition within the tapetal fundus and subsequent retinal degeneration resulting in visual deficits. Affected dogs may also exhibit neurological signs that include ataxia and hindlimb proprioceptive deficits. In all cases, circulating plasma concentrations of α-tocopherol are low. This study sought to investigate the genetic basis of retinopathy with vitamin E deficiency in the English Cocker Spaniel breed. We undertook a genome-wide association study comprising 30 English Cocker Spaniels with normal fundic examinations aged 6 years or older (controls) and 20 diagnosed with retinopathy with vitamin E deficiency (cases) and identified a statistically associated signal on chromosome 29 (Praw = 1.909 × 10−17). Whole genome sequencing of 2 cases identified a 102 bp deletion in exon 1 of the alpha-tocopherol transfer protein gene (TTPA), truncating the protein by 34 amino acids. The c.23_124del variant segregated with retinopathy with vitamin E deficiency in a total of 30 cases and 43 controls. Variants in TTPA are causal for ataxia with vitamin E deficiency in humans which is a phenotypically similar disease to retinopathy with vitamin E deficiency. The identification of the canine variant is extremely significant as the availability of a DNA test will allow for identification of presymptomatic dogs and early therapeutic intervention which may prevent development of retinopathy and improve neurological signs. Breeders can also use the DNA test to efficiently eradicate the disease from this breed.
Within- and Between-Person Differences in Activity Factor Structure: Results from an Ecological Momentary Assessment Study
Authors: Bielak Allison A M , Mogle Jacqueline A , Sliwinski Martin J 
Published: January 2025

Abstract

Objective
Studies using ecological momentary assessment (EMA) of activity participation rely on items tapping domains informed by factor analyses based on single time points. Analyses from a single time point focus on differences between participants and provide little insight into how activities cluster together within a person across moments or days. The present study compared the factor structure in activity participation between- and within-persons using an expanded set of momentary activity items in middle and older adulthood.

Methods
Using tablets, 81 adults aged 41 to 94 years reported activities completed in the past 3-4 hours five times per day for 14 days.

Results
The most common activities during the day involved social interactions, reading, and computer work. Watching TV or videos was the most common evening activity. Multilevel factor analysis simultaneously computed both intra-individual factors (within-person) and inter-individual factors (between-person). Four within-person and 4 between-person factors provided the best model fit, with three common factors: cognitive (read, computer); social (events, mentoring, providing care); and passive (TV, games) factors. There were notable differences in the fourth factor.

Discussion
Although three common activity factors were found between individuals and within persons from day to day, the divergence between the fourth intra- and inter-individual factors provides insight into how activity engagement operates at different timescales and likely reflect daily demands versus long-term goals. EMA provides a window into engagement throughout and across days, but researchers who commonly use retrospective reports of between-person activity engagement may find distinctly different results from factor analyses.
What Is the State of the Literature About Refugees Aged 45 and Older from Burma in Third-Country Resettlement Contexts?: A Scoping Review
Authors: Kitchens Katherine , Sesay Benjamin J , Fields Noelle L , Stringfellow Mary Kris , Mitschke Diane B 
Published: January 2025

Abstract

Background and Objective
Older adult refugees from Burma face unique challenges in third-country resettlement, yet their experiences are often overlooked in research and policy. This scoping review aims to examine the literature on refugees aged 45 and older from Burma in third-country resettlement contexts, identify factors contributing to successful integration, and elucidate the unique challenges they encounter.

Research Design and Methods
We systematically searched seven databases using Arksey and O’Malley’s framework. Studies were selected if they included refugees from Burma aged 45 and older in third-country resettlement contexts. Data were analyzed using Ager and Strang’s conceptual framework of refugee integration.

Results
Six studies met the inclusion criteria. Key findings highlighted disparities in health outcomes based on pre-resettlement environments, the interplay between chronic health issues and employment challenges, the importance of family bonds and institutional support, language proficiency barriers, and the impact of citizenship on self-perception. Instances of resilience and post-traumatic growth were noted, alongside lower reported well-being among older refugees compared to younger counterparts.

Discussion and Implications
The review revealed complex interactions between health, employment, social connections, language proficiency, safety, and citizenship in the integration experiences of older refugees from Burma. Findings underscore the need for integrated support systems addressing health and employment, flexible family reunification policies, tailored language acquisition programs, and clear pathways to citizenship. Future research should focus on longitudinal studies, specific employment support strategies, and the long-term impacts of institutional support on integration.
Daily Cognition in the Family Context: The Complex Associations between Memory Lapses, Family Relationships, and Affect in Middle-Aged and Older Adults
Authors: Jang Heejung , Hill Nikki L , Turner Jennifer R , Almeida David M , Jeong Mijin , Mogle Jacqueline 
Published: January 2025

Abstract

Background and Objectives
The analysis of daily memory lapses is an underutilized approach to understanding daily experiences of cognitive functioning. The present study adopts this approach, with the goals of exploring how the quality of family relationships predicts the frequency of daily memory lapses and moderates the link between daily memory lapses and daily affect.

Research Design and Methods
We used longitudinal data from the third wave of Midlife in the United States and the National Study of Daily Experiences to assess our research goals. Participants (N = 1,236; Mage= 62.48 years, SD= 10.21, range 43-91; 57% female) completed eight nightly telephone interviews that included reports of prospective and retrospective memory lapses as well as daily positive and negative affect.

Results
During a separate baseline interview, participants reported the emotional support they received from their family. Latent profile analysis models identified four family relationship types: pleasant, ambivalent, neutral, and unpleasant. Compared to pleasant relationships, ambivalent (b=.23, p&lt;.05) and neutral (b=.35, p&lt;.01) relationships significantly predicted a higher frequency of prospective memory lapses; this effect was not found among retrospective lapses. In addition, relative to pleasant relationships, ambivalent (b=.02, p&lt;.05), neutral (b=.02, p&lt;.05), and unpleasant (b=.07, p&lt;.001) relationships were associated with increased negative affect on days with a retrospective lapse, but not prospective lapse.

Discussion and Implications
This study contributes to the literature by revealing that family relationships are related to the memory lapses individuals experience in their daily lives, and identifies how lapses might contribute to affective symptom load over time.
Current tectonic deformation of the Sulaiman Range (Pakistan) with InSAR
Authors: Jouanne François , Pousse-Beltran Lea , Doin Marie-Pierre , Bascou Pascale , Thollard Franck , Ahmed Awais 
Published: January 2025

SUMMARY
In Pakistan, the relative displacement between the Indian and Eurasian plates is accommodated by a left-lateral transpression zone comprising the Chaman and Ghazaband faults and the Sulaiman Range. The current tectonic deformation of the Sulaiman Range is known only from some focal mechanisms and a few neotectonic studies. In this study, we propose an Interferometric Synthetic-Aperture Radar (InSAR) quantification of current tectonic deformation using the Sentinel 1 satellite. Velocity maps for the ascending and descending tracks enabled us to locate active faults affected by creep: the Harnaï and Kingri strike-slip faults, and the Gwal–Bagh thrust. We propose a numerical simulation that considers these faults as well as the level of detachment fold-and-thrust belt. Our results suggest the existence of out-of-sequence deformation along the Gwal–Bagh thrust, creep along the Harnaï and Kingri strike-slip faults, and slip along the décollement of the Sulaiman Range. The eastern part of the Sulaiman Range is characterized by a partitioning of the deformation with a left-lateral strike-slip along the N170° Kingri fault and an eastward thrust. In contrast, the western part is characterized by north–south compressive deformation associated with right lateral strike-slip on the Harnaï N120° fault. Modelling of the coseismic deformation of the 2021 October 21 earthquake shows that this earthquake occurred on a fault with a ramp geometry, but affected by a strike-slip motion.