bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cash Turnover, Receivables Turnover and Inventory Turnover on The Profitability of Pharmaceutical
Authors: Fajar Ilmiyono Agung 
Published: December 2023

The business run by the company aims to create the highest possible profit, this profit is expected to continue to be generated in the short and long term. Investment is very necessary in achieving maximum profit. The investment consists of working capital such as: Cash, Accounts Receivable, and Inventory. In increasing profitability, it is followed by cash turnover, receivables turnover and inventory turnover which can rotate effectively every period. This study aims to examine the effect of Cash Turnover, Receivable Turnover and Inventory Turnover on the profitability of the Pharmaceutical Sub-sector companies listed on the Indonesia Stock Exchange. The sampling technique used in this study was purposive sampling method. The analysis model of this research is Multiple Linear Regression Analysis. The results of the study partially show that Cash Turnover, Accounts Receivable Turnover and Inventory Turnover have no significant effect on the profitability of the pharmaceutical sub-sector companies listed on the Indonesia Stock Exchange. Simultaneous research results show that cash turnover, accounts receivable turnover, and inventory turnover have no significant effect on the profitability of pharmaceutical sub-sector companies listed on the Indonesia Stock Exchange.
Keyword: Cash Turnover, Inventory Turnover, Profitability, Receivable Turnover
Chronic pancreatitis in comorbidity with gastroesophageal reflux disease (features of the course of gastroesophageal reflux disease)
Authors: Khristich T. N. , Hontsariuk D. O. 
Published: December 2023

In this article, the authors emphasize the relevance of studying the features of the course of gastroesophageal reflux disease (GERD) both in children and adults, and in old age (including chronic pancreatitis). Attention is drawn to the different important mechanisms of GERD development in children and adults. As it is impossible to collect anamnesis in children before they start speaking, it is necessary to ask the parents about the so-called “red flags” (frequent fountain-like vomiting, the child is badly gaining weight, repeated pneumonia, diarrhea, refusal to drink or eat). One of the important features is a child’s crying during 1–2 hours.
It is difficult to make a differential diagnosis in adults between GERD phenotypes, especially in comorbidity with chronic pancreatitis, which makes appropriate adjustments to the clinical picture (which the authors focus on). Differential diagnosis of non-erosive GERD, such GERD phenotypes as reflux esophageal hypersensitivity, functional heartburn, low and high grade reflux esophagitis, Barrett’s esophagus, regurgitation-dominant GERD, extraesophageal phenotype and reflux chest pain syndrome is carried out.
The authors agree with those provisions that indicate that GERD is a family of different syndromes that differ in the mechanisms of development, clinical picture and make up certain phenotypes of the disease, which require a differentiated approach to treatment tactics and strategies, secondary prevention (including chronic pancreatitis).
How I loved the life!
Authors: Gubergrits N. B. , Borodiy K. N. , Lukashevich G. M. 
Published: December 2023

This publication is dedicated to the British Princess Marie Alexandra Victoria of Edinburgh, known after marriage as Marie of Romania. The beautiful, educated, talented, rich Queen not only held the hearts of contemporaries with her achievements in the literary field, painting, and dancing, but also with her sincere concern for ordinary people. During World War I, Marie, who was known as the “mother of the wounded”, took care of the wounded soldiers with cholera, day and night without a break, along with other nurses.
As contemporaries believe, Marie’s cause of death was pancreatic cancer, however, due to various circumstances, liver cirrhosis was considered the official cause of the Queen’s death. Unfortunately, medical workers of the 20th century could not significantly affect the course of the disease, but they tried to relieve pain syndrome and maintain the general condition of the national favorite. The last words of the Queen (not only by origin, but also by spirit) vividly emphasize the love of life, resilience and majesty of this woman: “How I loved life!”
Depressive syndrome in gastroenterology
Authors: Tsimmerman Ya. S. , Tsimmerman I. Ya. 
Published: December 2023

Depression has recently expanded beyond psychiatry to become a general medical problem. Psycho-emotional stress is the main factor that provokes anxiety-depressive disorders. There is a two-way connection between the psyche and the somatics: mental disorders affect somatic functions, and somatic diseases, in turn, affect the state of the psyche.
In this article, the author pays attention to the most common gastroenterological diseases associated with mental disorders. They include: peptic ulcer, functional (gastroduodenal) dyspepsia syndrome, irritable bowel syndrome, functional forms of chronic duodenal obstruction syndrome, chronic cholecystitis and associated extrahepatic biliary dyskinesia.
As for the digestive system, psychosomatic disorders are manifested by nausea and vomiting, belching, flatulence, abdominal pain, rumbling and splashing in the intestines, constipation or diarrhea, dry mouth. Anxiety-depressive syndrome in patients is characterized by dyssomnia, chronic anxiety, bodily discomfort, hypothymia, synestopathy, somatoform disorders, frustration, alexithymia, etc.
The main criteria and diagnostic tools for depression are described (international classifications, self-assessment scales, diagnostic tests).
In addition to the basic individualized therapy for somatic diseases, patients usually need additional prescription of psychotropic drugs and psychological support. The main technique of treatment is psychotherapy (less often — hypnotherapy). Only upon the ineffectiveness of psychotherapy, doctors should resort to the appointment of psychotropic drugs of four different groups: anxiolytics, antidepressants, “small” antipsychotics, nootropics.
Prevention of emotional burnout in medical professionals
Authors: Trush E. N. 
Published: December 2023

More than a third of doctors in Ukraine experience this problem, but most of them do not receive specialized help in this matter. Specialists who have the highest risk of EBS: urologists (54%), neurologists (53%), rehabilitation specialists (52%), therapists (49%), ambulance doctors (48%), family doctors (48%).
The main causes of EBS in physicians are a large number of bureaucratic tasks (59%), a lot of time at work (34%), digital workload (32%). With increasing age and length of service in the profession, indicators of burnout tend to increase. The most intensive EBS is observed in employees of outpatient clinics (45%) and health care institutions (49%).
There are physical, behavioral, emotional, intellectual symptoms of EBS. The most disturbing symptoms are personal deformity, pessimism, negativism, social self-isolation, loss of empathy, indifference to the loved ones, the environment and patients. Such doctors become not only unfit for work, but also professionally dangerous because of the risk of harm to patients.
To diagnose EBS in health professionals, the author of the article proposes to use the questionnaire “Professional (emotional) burnout”, developed on the basis of a three-factor model by K. Maslach and S. Jackson. The technique is designed to diagnose emotional exhaustion, depersonalization and professional achievement. The test contains 22 statements about the feelings and experiences associated with the performance of work activities. The obtained results can be used to develop measures to prevent loss of interest in professional activities.
The most popular measures to combat EBS: sports (48%), communication with family members and close friends (43%), self-isolation (41%). EBS is easier to prevent than to treat, so special attention is paid to prevention methods. To reduce the risks of EBS, it is necessary to increase psychological competence, give way to negative emotions, expand the range of interests, quickly resolve conflicts, do not delay in obtaining specialized help, do not look for negativity around you. The article also offers twelve “rituals” of emotional hygiene, which are recommended to be performed regularly.
On the features of the correction of intestinal dysbiosis in chronic pancreatitis (literature review)
Authors: Ferfetska K. V. , Hontsaryuk D. O. , Pits L. O. , Pits V. A. 
Published: December 2023

The aim of the literature review was to analyze the modern approach to the correction of intestinal dysbiosis in patients with chronic pancreatitis, including the one combined with metabolic syndrome, coronary heart disease, and especially bacterial overgrowth syndrome.
Particular attention is paid to the peculiarities of drug therapy and the pharmacotherapeutic mechanisms of influence of various groups of pro-, pre- and synbiotics on the condition of the intestine, immunity, and inflammatory processes. The requirements for an adequate selection of drugs are considered. They must be useful for the human body; should not cause side effects during long-term use, but should have a minimal ability to translocate from the lumen of the intestine to internal organs; must be resistant to low pH values, the influence of bile acids, and antimicrobial substances produced by endogenous microflora; adhere well to the epithelium of mucous membranes; have a high rate of growth and reproduction in the intestines; and must have a clear physiological, biochemical, and genetic marking. Efficacy criteria are the probiotic effect proven in double-blind placebo-controlled studies. These requirements are met by B. bifidum, Lactobacillus acidophilus, Lactobacillus GG, Lactobacillus fermentum, Strepto(Entero)coccus faecium, Saccharomyces boulardii, which are components of many probiotics.
Interesting information is provided about the probiotic with level A evidence, called Enterol by the WHO experts: it is a self-eliminating probiotic, each capsule of which contains 250 mg of lyophilized cells of a selective strain of medicinal yeast, Saccharomyces boulardii. It is crucial that the drug prevents the growth of a wide range of pathogenic microorganisms and fungi and promotes their elimination (Clostridium difficile, Clostridium pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Candida crusei, Candida pseudotropical, Candida albicans, Salmonella typhi, Salmonella enteriditis, Escherichia coli, Shigella dysenteriae, Shigella flexneri, Klebsiella, Proteus, Vibrio cholera, Enthamoeba hystolitica, Enterovirus, Rotavirus).
Consequences of chronic pancreatitis and exocrine pancreatic insufficiency, or When leaves fall from trees
Authors: Gubergrits N. B. , Byelyayeva N. V. , Mozhyna T. L. 
Published: December 2023

Aim. To analyze current literature data on the complications of chronic pancreatitis (CP) with exocrine pancreatic insufficiency (EPI).
Main statements. According to statistical evidence, the presence of CP is associated with an increased risk of death, while the concomitant EPI significantly increases the risk of death. EPI is a big independent risk factor for death in patients with CP, which emphasizes the need for adequate correction of EPI in order to reduce mortality in this group.
EPI is associated not only with an increase in mortality in CP patients but also with the development of various trophological defects. It has been stated that CP course is accompanied by a decrease in the level of albumin, malabsorption of fat-soluble vitamins (A, E, and D), carotenoids (beta-carotene, lycopene, cryptotaxin, and zeaxanthin), and the development of osteopenia and osteoporosis. CP course is linked to anxiety, depression, tumor pathology (pancreatic ductal adenocarcinoma, esophageal cancer, and stomach cancer), damage to the cardiovascular system, an increase in cardiovascular risk, and a high chance of myocardial infarction, stroke, and pancreatitis-induced thrombosis of the splenic vein. Modern enzyme replacement therapy makes it possible to compensate for some of the consequences of chronic EPI, reduce numerous signs of malnutrition, normalize the body mass index, and improve the quality of life of CP patients with EPI.
Clinical evaluation of the effectiveness of procalcitonin in diagnosing purulent septic complications of acute necrotizing pancreatitis
Authors: Rotar O. V. , Khomiak I. V. , Petryuk B. V. , Khomiak A. I. , Railianu S. I. , Barbu S. 
Published: December 2023

Purulent septic complications seriously worsen the prognosis for patients with acute necrotizing pancreatitis. Early diagnosis is an important issue in establishing the effectiveness of their conservative and interventional treatment. Recently, procalcitonin (PCT) has been suggested as a diagnostic criterion for bacterial contamination of pancreatic necrotic tissue.
The aim of study is to estimate PCT efficacy for early diagnosis of purulent septic complications of acute necrotizing pancreatitis and to investigate its use for disease prognosis.
Materials and methods. A prospective cohort study of 151 patients with severe acute necrotizing pancreatitis was conducted. Clinical, laboratory, and bacteriological studies were carried out. Serum levels of PCT were determined during hospitalization, before intervening treatment, and in the postoperative period.
Results and discussion. Infected acute necrotizing pancreatitis was diagnosed in 89 (55.6%) patients. Local purulent complications were revealed in 27 patients, sepsis in 33, and septic shock in 29. PCT concentration was higher in 62 patients with sterile pancreatic necrosis than in healthy individuals, reaching 1.34±0.19 ng/ml (p=0.045). The development of infected acute necrotizing pancreatitis was accompanied by increased PCT levels in patients with sepsis (up to 5.03±1.38 ng/ml; p=0.001), septic shock (up to 7.21±1.91 ng/ml; p=0.001), and local purulent septic complications (up to 2.03±0.48 ng/ml; p=0.072). The PCT levels above 4.0 ng/ml were prognostically unfavorable for patient survival.
Conclusion. PCT levels in the blood serum are an effective criterion for diagnosing generalized purulent septic complications of acute necrotizing pancreatitis. Its levels above 4.0 ng/ml indicate an unfavorable prognosis for patient survival.
Controlling the quality of medical care: key aspects of a systematic approach and international experience
Authors: Trush O. M. 
Published: December 2023

Safety, quality of life, and ensuring the best results for the health of patients are the main goals of healthcare institutions and the system as a whole. The modern approach to ensuring stable and reproducible quality of medical services was shaped in the last century, and has now reached a high degree of generalization. Control in this field is a multi-level process that covers all parts of the medical institution’s activities, from logistics to personnel management.
Indicators of the quality of medical services from the patient’s side range from potentially complex (postoperative morbidity and mortality) to simple (the frequency of hospital-acquired infections or surgical errors). When all of the clinic’s main business processes are clearly set up and improved as needed, this is called “process management.” This makes it possible to design quality by taking into account the indicators of meeting the requirements of technical documents.
The ISO 9000 family of standards, which is successfully used and adopted worldwide in healthcare organizations, contains requirements, specifications, instructions, and tools for the provision of products and services. They simplify comparison, information exchange, big data aggregation, and privacy protection. Regarding the patients, the standards are designed to provide high-quality, safe, and reliable products and services. There are certain precautions about an overly technological approach during quality assurance and control, but now the greatest threat is considered to be the destructive impact of war and the disruption of habitual relationships and processes.
The state of medical care, the damage to the material fund, the depletion of human resources, and the lack of financial and other resources are all concerning. Fragmentation of healthcare and unequal access in different regions and social groups are potentially threatening. Examples of countries with long-term military conflicts on their territory indicate the “erosion” of activity standards, which are usually set by external actors in such conditions in response to the limited institutional, technical, and managerial capabilities of countries in a state of conflict. Complex measures to restore the functionality of the medical care system are organized at the level of communities, individual institutions, and their associations. In this case, the first steps are the most important, since they often determine the development for years and decades ahead. Therefore, the restoration, or sometimes the “reset,” of the domestic system is an exceptional opportunity to re-prioritize, correct shortcomings, and establish stronger ties with the global professional community.
Comments on the European Guideline on IgG4-related Digestive Disease
Authors: Gubergrits N. B. 
Published: December 2023

The main aim of the comments is to point out the most significant aspects of diagnosis and treatment of immunoglobulin G4 (IgG4)-related gastrointestinal diseases (IgG4-AGD), as described in European guidelines. According to the guidelines, measuring the amount of IgG4 in the serum cannot be used to confirm a diagnosis of IgG4-AGD on its own. The diagnosis of this pathology is based on a comprehensive assessment of serological and imaging studies, histological and immunohistochemical studies, the assessment of other organs’ damage, and the effectiveness of systemic glucocorticoids. Oral glucocorticoids are administered for symptomatic patients (obstructive jaundice, abdominal pain, pancreatic pain, liver, bile duct, esophagus, stomach, small and large intestine lesions), as well as asymptomatic patients with persistent cholestasis against the background of IgG4-related cholangitis and the presence of a mass lesion according to imaging studies to exclude malignant neoplasia. A typical starting dose of glucocorticoids is 0.6–0.8 mg/kg/day, or 30–40 mg/day of prednisolone equivalent. This dose of steroid should be administered orally for one month to induce remission. Subsequently, a gradual decrease in the dose of glucocorticoids begins over 3–6 months. Evaluation of the effectiveness of initial therapy with glucocorticoids is carried out after 2–4 weeks of taking steroids based on a comprehensive analysis of physical data and the results of biochemical, instrumental, and histological studies. The systemic course of the disease, with multiple organ damage or relapses, suggests the use of glucocorticoid maintenance doses. If there are no changes in the course of the disease after three months of treatment, even if the dose of glucocorticoids is reduced or the drug is withdrawn, immunosuppressive drugs (rituximab) are prescribed to keep the disease in remission.
Revisiting the question of endolymphatic therapy
Authors: Kajryak O. V. , Gubergrits N. B. 
Published: December 2023

Lymphotropic therapy was the first step in the development of endolymphatic therapy. Lymphotropic therapy was carried out by creating a subcutaneous depot of a contrast agent or injecting the drug directly into the lymph node. The next step was the introduction of the drug into the lymphatic system by a single puncture of the peripheral lymphatic vessel. After G. V. Bondar put his idea into action by making a special tool, it became possible to do long-term endolymphatic infusion.
Lymphatic catheterization is performed in a clean operating room. Catheterization of the thigh lymphatic vessels is the most common technique. A network of superficial lymphatic vessels extends from the medial edge of the sartorius muscle into the subcutaneous fat, reaching the lower superficial inguinal lymph nodes. The deep lymphatic vessels of the thigh are adjacent to the femoral vein. The use of a longitudinal or longitudinal-oblique skin incision is preferable. The benefits of this access are that lymphatic vessels can be catheterized more than once during chemotherapy and wounds heal faster because the skin is cut along the fibers instead of across them.
When comparing endolymphatic and intravenous methods of administration of platinum group chemotherapy drugs in combination with fluorouracil or methotrexate in 289 patients with T3N0-1 M0-1 ovarian cancer, the vast majority of whom had serous adenocarcinomas (85.62±2.77 and 84.93±3.17), a significantly higher frequency of complete and partial regressions was registered (59.63±3.87%) with the endolymphatic technique than with intravenous administration (32.03±4.14%).
Endolymphatic chemotherapy with fluorouracil 700–800 m g/m daily for 5 days in combination with intravenous administration of doxorubicin 40 mg/m in the treatment of patients with advanced, inoperable gastric cancer (n=33) increased overall efficacy to 39.4%±8.5% when compared to patients (n=32) who received the same drugs intravenously (12.5%±5.84%). The compared groups had significantly different median survival (35 and 19 weeks) and life expectancy (41.3±4.4 and 23.8±3.4 weeks).
The endolymphatic administration of cytostatics, which demonstrates less toxicity compared to the intravenous one, has the right to exist and the potential to further develop improved techniques of administration.