bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical properties and statistical analysis of Syagrus Romanzoffiana palm cellulose fibers
Authors: Ferfari Oussama , Belaadi Ahmed , Boumaaza Messaouda , Amroune Salah , Alshahrani Hassan , KA Khan Mohammad 
Published: January 2024

Explore the intriguing world of natural fibers, where Syagrus Romanzoffiana (SR) fibers out as a viable alternative to synthetic and glass fibers in composite materials. Dive into the eco-friendly attraction of SR fibers, which are renowned for their natural degradation and ecologically favorable properties. This novel work investigates the performance characterization of 40 mm gauge-length (GL) SR fibers under quasi-static pressures using rigorous tensile testing. The mystery develops when 200 fibers are examined in seven different test groups, revealing the effect of test quantity ( N) on tensile strength, Young’s modulus, and fracture strain. Given the intrinsic diversity of natural fibers, the study applies strong statistical approaches such as least squares (LS) and maximum likelihood (ML) estimations, as well as two- and three-parameter Weibull distributions. Witness the thorough dispersion and probability analysis, which culminates in an enthralling one-factor analysis of variance (ANOVA) across the seven test groups ( N = 30, 60, 90, 120, 150, 180 and 200) for each tensile strength characteristic. Join us on this scientific trip as we uncover the mysteries and promise of Syagrus Romanzoffiana fibers to shape the future of composite materials.
12-Year Trends of Orofacial Clefts in the United States: Highlighting Racial/Ethnic Differences in Prevalence of Cleft Lip and Cleft Palate
Authors: Taritsa Iulianna C. , Ledwon Joanna K. , Bajaj Anitesh , Gosain Arun K. 
Published: January 2024

Objective Discrepancies in prevalence among infants with orofacial clefts are public health research priorities. Our objective was to calculate updated estimated prevalence of orofacial clefts in the United States, with sub-analyses by racial/ethnic group. Design The National Birth Defect Prevention Network database was used to evaluate trends in cases with orofacial cleft in the United States from 2006 to 2018. Cases with cleft lip with and without cleft palate (CL ± P) and cleft palate (CP) alone were sub-stratified by racial/ethnic category. Estimated prevalence was calculated using the total live births reported in each maternal racial/ethnic group. The odds ratio (OR) was calculated to measure the strength of association between racial/ethnic group and risk of orofacial clefts. Results Estimated prevalence rates show that maternally-reported Native American/Alaskan Native individuals were 43.8% ( p < 0.0001) and 36.0% ( p < 0.0001) more likely to have CL ± P and CP alone, respectively, compared to maternally-reported non-Hispanic White individuals. Estimated prevalence of CL ± P in maternally-reported non-Hispanic Black individuals (OR = 0.64) and maternally-reported Asians/Pacific Islander individuals were significantly lower than in maternally-reported non-Hispanic White individuals (OR = 0.63, p < 0.0001). Estimated prevalence of CP alone was significantly lower in maternally-reported non-Hispanic Black individuals (OR = 0.64, p < 0.0001), maternally-reported Asians/Pacific Islander individuals (OR = 0.69, p < 0.0001), and maternally-reported Hispanic individuals (OR = 0.81, p < 0.0001). Conclusions Across the total population, there was no significant change in estimated orofacial cleft prevalence. However, there were significant disproportions in estimated orofacial cleft prevalence across racial/ethnic groups, which may guide further discussion among craniofacial health care providers and centers and their patients regarding differences in cleft risk factors.
Incidence of pulmonary toxicity in bleomycin-containing regimens for testicular cancer with and without the use of growth factor
Authors: McAvoy Claire , Fields Paige , Otto Danielle , Kreimer Alexander , Ellis Carleton S 
Published: January 2024

Introduction The concurrent use of bleomycin and granulocyte colony-stimulating factors (G-CSFs) has historically been debated as a risk factor for bleomycin-induced pulmonary toxicity in patients with both testicular cancer and Hodgkin's lymphoma. The purpose of this study is to evaluate the incidence of pulmonary toxicity in patients with testicular cancer who were treated with bleomycin and pegfilgrastim concurrently. Methods This is a retrospective study that includes male patients over the age of 18 years old diagnosed with testicular cancer who received bleomycin-containing chemotherapy regimens with and without the use of G-CSF agents. Results There were a total of 33 patients identified as receiving bleomycin, with 30 of those patients having received concurrent G-CSF therapy. Of the patients who received G-CSF therapy, 11 patients (36.6%) experienced pulmonary toxicity leading to discontinuation of bleomycin or changes in chemotherapy regimens altogether. Conclusion There were no major differences in patient demographics or risk factors between those who received G-CSF and developed pulmonary toxicity and those who received G-CSF but did not develop pulmonary toxicity. Further studies are needed in order to fully assess the risk of pulmonary toxicity with this chemotherapy regimen.
Continuation of Treatment in Children With ADHD: A Multicenter Turkish Sample Study
Authors: Baykal Saliha , Çobanoğlu Osmanlı Cansu , Bozkurt Abdullah , Önal Bedia Sultan , Şahin Berkan , Karaçizmeli Müge , Öz Gazi Ayşegül , Karabekiroğlu Koray 
Published: January 2024

Objectives: The aim of this study was to investigate the variables that may affect treatment continuation in children aged 6 to 12 years who were newly diagnosed with ADHD. Methods: A total of 132 children diagnosed with ADHD and their parents participated in the study. Sociodemographic and clinical risk factors affecting continuation of treatment were examined using logistic regression analysis. Results: Multiple model examination revealed that greater age increased the risk of treatment discontinuation 1.824 times ( p = .003) while a lower total length of paternal education increased the risk of discontinuation (1/0.835) 1.198 times ( p = .022). Other variables emerging as significant in the univariate model lost that significance in the multiple model. Conclusions: Understanding the variables associated with medication discontinuation in ADHD in different populations and taking these variables into account in the development of health policies, will be useful in improving the long-term devastating effects of the disorder.
Pharmacokinetic Analysis of Prognostic Factors in Patients With Advanced-Stage Intrahepatic Cholangiocarcinoma Following the Administration of Capsule Formulation of the Standardized Extract of Atractylodes lancea (Thunb) DC
Authors: Saeheng Teerachat , Karbwang Juntra , Cheomung Anurak , Tongsiri Nisit , Plengsuriyakarn Tullayakorn , Na-Bangchang Kesara 
Published: January 2024

Background: A statistical model is essential in determining the appropriate predictive indicators for therapies in many types of cancers. Predictors have been compared favorably to the traditional systems for many cancers. Thus, this study has been proposed as a new standard approach. A recent study on the clinical efficacy of Atractylodes lancea (Thunb) DC. (AL) revealed the higher clinical benefits in patients with advanced-stage intrahepatic cholangiocarcinoma (ICC) treated with AL compared with standard supportive care. We investigated the relationships between clinical efficacy and pharmacokinetic parameters of serum bioactivity of AL and its active constituent atractylodin and determined therapeutic ranges. Methods: Group 1 of advanced-stage ICC patients received daily doses of 1000 mg of standardized extract of the capsule formulation of AL (CMC-AL) for 90 days. Group 2 received daily doses of 1000 mg of CMC-AL for 14 days, followed by 1500 mg for 14 days, and 2000 mg for 62 days. Group 3 (control group) received palliative care. Cox proportional hazard model and Receiver Operating Characteristic (ROC) were applied to determine the cut-off values of AUC0-inf, Cmax, and Cavg associated with therapeutic outcomes. Number needed to treat (NNT) and relative risk (RR) were also applied to determine potential predictors. Results: The AUC0-inf of total AL bioactivity of >96.71 µg hour/ml was identified as a promising predictor of disease prognosis, that is, progression-free survival (PFS) and disease control rate (DCR). Cmax of total AL bioactivity of >21.42 was identified as a predictor of the prognosis of survival. The therapeutic range of total AL bioactivity for PFS and DCR is 14.48 to 65.8 µg/ml, and for overall survival is 10.97 to 65.8 µg/ml. Conclusions: The predictors of ICC disease prognosis were established based on the pharmacokinetics of total AL bioactivity. The information could be exploited to improve the clinical efficacy of AL in patients with advanced-stage ICC. These predictors will be validated in a phase 2B clinical study. Trial Registration: TCTR20210129007 (TCTR: www.clinicaltrials.in.th).
Investigating raised white cells, sepsis and antibiotic administration in obstructive urolithiasis: A retrospective cohort analysis
Authors: Akiboye Deji , Leung Yan , Taheem Muhesh , Gordon Stephen 
Published: January 2024

Objectives: Patients with obstructive ureteric calculi frequently present with leucocytosis, prompting empirical antibiotic treatment. Evidence for antibiotics in these cases is limited. This study investigated whether leucocytosis is a reliable marker of sepsis in obstructive urolithiasis, and assessed factors associated with sepsis after emergency department (A&E) discharge, including antibiotic administration. Methods: Retrospective data collection was performed on all patients with computed tomography (CT)-proven ureteric calculi presenting to a single centre A&E between October 2019 and October 2020. Data were collected on patient demographics, comorbidities, stone factors, serum and urinalysis and relevant culture results. Multivariable regression analysis assessed significant correlations for immediate/delayed sepsis, serum leucocytes and antibiotic administration. Results: In total, 392 patients (298:98 M:F) met the inclusion criteria. Raised leucocytes were found in 212 patients (54.4%) with 24 patients (6.1%) admitted immediately with sepsis, and 12 (3.1%) returning with sepsis. In total, 83 patients received antibiotics, of whom 57 (68.7%) had no immediate or delayed sepsis. Multivariable regression showed immediate sepsis significantly associated with stone size, presence and degree of type 2 diabetes ( p < 0.012). Re-presentation with sepsis significantly correlated with female gender and multiple stones ( p < 0.039) with antibiotic administration showing no benefit. Raised leucocytes showed no relation to immediate sepsis or delayed sepsis ( p > 0.33). Conclusions: Leucocytosis alone is not a reliable marker of sepsis with obstructing ureteric stones. Septic patients are more likely to have severe diabetes with larger stones; female patients with multiple calculi are more likely to re-present with sepsis. In our cohort, antibiotics did not prevent re-presentation with sepsis and should not be given unnecessarily. Level of evidence: Level 4
The influence of social environment and facility support on smoking in adolescent males in Indonesia
Authors: Artanti Kurnia Dwi , Arista Rosaline Dinda , Fazmi Tatu Indira Khairunnisa 
Published: January 2024

Background: The high number of smokers in Indonesia, including adolescents, causes high morbidity due to smoking. Reducing the incidence of smoking-related disease in Indonesia needs to be done by reducing the number of smokers. This can be done by preventing smoking as early as possible, including during adolescence. The study aimed to assess the prevalence of adolescent male smokers and determine the social environment and facility support that influences smoking behavior in adolescent males aged 15–18 years in Surabaya, Indonesia. Design and method: A cross-sectional study was performed from 1st October 2021 to 31st January 2022 on adolescent males aged 15 to 18 from senior high schools in Surabaya. 369 respondents completed a self-administered questionnaire about social environment and facility support that influence smoking behavior. The questionnaire result of the questionnaire was computed using bivariate analysis to examine the relationship between social environment, facility support, and smoking behavior. Result: Of the 369 eligible participants, 95 (25.7%) were smokers, while the remaining 274 were not. The factors affecting smoking among adolescents were families influence ( p = 0.000; PR = 4.805; CI = 2.923–7.900), friends influence ( p = 0.000; RP = 3.987; CI = 2.4906.383), and advertisements influence ( p = 0.000; RP = 3.137; CI = 2.275–4.325). Facility support was not found to be too influential ( p = 0.399; RP = 0.767; CI = 0.472–1.245). Familia influence was the strongest factor in smoking among adolescent males aged 15 to 18. Conclusions: Integrated programs and policies are needed to prevent and rehabilitate adolescents from smoking behavior. Improving their understanding of the health impacts of smoking is also needed.
Morphological Changes of the Posterior Femoral Condyle After Medial Patellar Retinaculum Plasty in Skeletally Immature Patients With Recurrent Patellar Dislocation and Trochlear Dysplasia
Authors: Guo Hailong , Zhou Kezhen , Sun Zhiwen , Feng Ao , Qin Shiqi , Liu Lei , Sun Ran , Wang Xiaofeng 
Published: January 2024

Background: Surgical correction for recurrent patellar dislocation (RPD) can improve femoral trochlear morphology; nonetheless, the effects of surgical correction on femoral condyle morphology are unclear. Purpose: To investigate the morphological changes in the posterior femoral condyle in skeletally immature patients with RPD and trochlear dysplasia (TD) after surgical correction. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 20 skeletally immature patients with bilateral RPD and TD were included in this study. For each patient, the knee that was dislocated more frequently or had sustained a recent injury was treated with medial patellar retinaculum plasty (group S; n = 20 knees), and the asymptomatic or only occasionally dislocated contralateral knee was treated conservatively (group C; n = 20 knees). The lengths of the anterior medial and lateral femoral condyles and the lengths of the posterior medial and lateral femoral condyles were evaluated preoperatively and at the final follow-up. Trochlear morphological characteristics, tibial tuberosity–trochlear groove distance, and patellar tilt angle were compared between preoperative and final follow-up values with the 2-sample paired Student t test and were compared between groups S and C with the independent-samples t test. Results: The mean follow-up time was 60.7 ± 4.8 months. No knee in group S experienced a redislocation, whereas 80% (16/20) of knees in group C experienced a dislocation. There were significant group differences in the ratio of the posterior medial femoral condyle (PMFC) to the posterior lateral femoral condyle (PLFC) (group S, 1.08 ± 0.05; group C, 1.14 ± 0.06; P = .042). There was no significant difference in the ratio of the anterior lateral femoral condyle to the anterior medial femoral condyle (group S, 1.16 ± 0.13; group C, 1.18 ± 0.09; P = .635). In group S, all trochlear morphological characteristics and patellofemoral joint characteristics improved compared with preoperatively ( P≤ .047 for all). In addition, all values significantly differed between groups S and C at the final follow-up ( P≤ .044 for all). Conclusion: The study findings demonstrated that the morphology of the posterior femoral condyle in skeletally immature patients with bilateral RPD and TD changes after surgical correction, with the PLFC growing faster than the PMFC.
Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia
Authors: Tarlock Katherine , Gerbing Robert B. , Ries Rhonda E. , Smith Jenny L. , Leonti Amanda , Huang Benjamin J. , Kirkey Danielle , Robinson Leila , Peplinksi Jack H. , Lange Beverly , Cooper Todd M. , Gamis Alan S. , Kolb E. Anders , Aplenc Richard , Pollard Jessica A. , Alonzo Todd A. , Meshinchi Soheil 
Published: January 2024

Abstract
We sought to define the cooccurring mutational profile of FLT3-ITD–positive (ITDpos) acute myeloid leukemia (AML) in pediatric and young adult patients and to define the prognostic impact of cooperating mutations. We identified 464 patients with FLT3-ITD mutations treated on Children’s Oncology Group trials with available sequencing and outcome data. Overall survival, event-free survival (EFS), and relapse risk were determined according to the presence of cooccurring risk stratifying mutations. Among the cohort, 79% of patients had cooccurring alterations across 239 different genes that were altered through mutations or fusions. Evaluation of the prognostic impact of the cooccurring mutations demonstrated that patients with ITDpos AML experienced significantly different outcomes according to the cooccurring mutational profile. Patients with ITDpos AML harboring a cooccurring favorable-risk mutation of NPM1, CEBPA, t(8;21), or inv(16) experienced a 5-year EFS of 64%, which was significantly superior to of 22.2% for patients with ITDpos AML and poor-risk mutations of WT1, UBTF, or NUP98::NSD1 as well to 40.9% for those who lacked either favorable-risk or poor-risk mutation (ITDpos intermediate; P &lt; .001 for both). Multivariable analysis demonstrated that cooccurring mutations had significant prognostic impact, whereas allelic ratio had no impact. Therapy intensification, specifically consolidation transplant in remission, resulted in significant improvements in survival for ITDpos AML. However, patients with ITDpos/NUP98::NSD1 continued to have poor outcomes with intensified therapy, including sorafenib. Cooccurring mutational profile in ITDpos AML has significant prognostic impacts and is critical to determining risk stratification and therapeutic allocation. These clinical trials were registered at www.clinicaltrials.gov as NCT00002798, NCT00070174, NCT00372593, and NCT01371981.
Comprehensive assessment of fine motor movement and cognitive function among older adults in China: a cross-sectional study
Authors: Zhang Jie , Zhao Ye-Jing , Wang Jun-Yi , Cui Han , Li Shaojie , Meng Xue , Cai Rui-Yu , Xie Juan , Sun Su-Ya , Yao Yao , Li Jing 
Published: January 2024

Abstract
Background
Fine motor skills are closely related to cognitive function. However, there is currently no comprehensive assessment of fine motor movement and how it corresponds with cognitive function. To conduct a complete assessment of fine motor and clarify the relationship between various dimensions of fine motor and cognitive function.

Methods
We conducted a cross-sectional study with 267 community-based participants aged ≥ 60 years in Beijing, China. We assessed four tests performance and gathered detailed fine motor indicators using Micro-Electro-Mechanical System (MEMS) motion capture technology. The wearable MEMS device provided us with precise fine motion metrics, while Chinese version of the Montreal Cognitive Assessment (MoCA) was used to assess cognitive function. We adopted logistic regression to analyze the relationship between fine motor movement and cognitive function.

Results
129 (48.3%) of the participants had cognitive impairment. The vast majority of fine motor movements have independent linear correlations with MoCA-BJ scores. According to logistic regression analysis, completion time in the Same-pattern tapping test (OR = 1.033, 95%CI = 1.003–1.063), Completion time of non-dominant hand in the Pieces flipping test (OR = 1.006, 95%CI = 1.000-1.011), and trajectory distance of dominant hand in the Pegboard test (OR = 1.044, 95%CI = 1.010–1.068), which represents dexterity, are related to cognitive impairment. Coordination, represented by lag time between hands in the Same-pattern tapping (OR = 1.663, 95%CI = 1.131–2.444), is correlated with cognitive impairment. Coverage in the Dual-hand drawing test as an important indicator of stability is negatively correlated with cognitive function (OR = 0.709, 95%CI = 0.6501–0.959). Based on the above 5-feature model showed consistently high accuracy and sensitivity at the MoCA-BJ score (ACU = 0.80–0.87).

Conclusions
The results of a comprehensive fine-motor assessment that integrates dexterity, coordination, and stability are closely related to cognitive functioning. Fine motor movement has the potential to be a reliable predictor of cognitive impairment.
Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients
Authors: Wang Shengnan , Wu Xingwei , Wu Xiaoming , Cheng Jin , Chen Qianyi , Qi Zhilin 
Published: January 2024

Abstract
Background
Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role of LDHs in pan-cancers.

Methods
Cox regression, Kaplan–Meier curves, Receiver Operating Characteristic (ROC) curves, and correlation of clinical indicators in tumor patients were used to assess the prognostic significance of LDHs in pan-cancer. The TCGA, HPA, TIMER, UALCAN, TISIDB, and Cellminer databases were used to investigate the correlation between the expression of LDHs and immune subtypes, immune checkpoint genes, methylation levels, tumor mutational load, microsatellite instability, tumor-infiltrating immune cells and drug sensitivity. The cBioPortal database was also used to identify genomic abnormalities of LDHs in pan-cancer. A comprehensive assessment of the biological functions of LDHs was performed using GSEA. In vitro, HepG2 and Huh7 cells were transfected with LDHD siRNA and GFP-LDHD, the proliferation capacity of cells was examined using CCK-8, EdU, and colony formation assays; the migration and invasion of cells was detected by wound healing and transwell assays; western blotting was used to detect the levels of MMP-2, MMP-9, E-cadherin, N-cadherin and Akt phosphorylation.

Results
LDHs were differentially expressed in a variety of human tumor tissues. LDHs subtypes can act as pro-oncogenes or anti-oncogenes in different types of cancer and have an impact on the prognosis of patients with tumors by influencing their clinicopathological characteristics. LDHs were differentially expressed in tumor immune subtypes and molecular subtypes. In addition, LDHs expression correlated with immune checkpoint genes, tumor mutational load, and microsatellite instability. LDHD was identified to play an important role in the prognosis of HCC patients, according to a comprehensive analysis of LDHs in pan-cancer. In HepG2 and Huh7 cells, knockdown of LDHD promoted cell proliferation, migration, and invasion, promoted the protein expression levels of MMP-2, MMP-9, N-cadherin, and Akt phosphorylation, but inhibited the protein expression level of E-cadherin. In addition, LDHD overexpression showed the opposite changes.

Conclusion
LDHs subtypes can be used as potential prognostic markers for certain cancers. Prognostic and immunotherapeutic analysis indicated that LDHD plays an important role in the prognosis of HCC patients. In vitro experiments revealed that LDHD can affect HCC proliferation, migration, and invasion by regulating MMPs expression and EMT via Akt signaling pathway, which provides a new perspective on the anti-cancer molecular mechanism of LDHD in HCC.