bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic landscape of breast cancer subtypes following radiation therapy: insights from comprehensive profiling
Authors: Wang Fang , Wang Weiyan , Wang Minglei , Chen Dawei 
Published: February 2024

BackgroundIn breast cancer, in the era of precision cancer therapy, different patterns of genetic mutations dictate different treatments options. However, it is not clear whether the genetic profiling of breast cancer patients undergoing breast-conserving surgery is related to the adverse reactions caused by radiotherapy.MethodsWe collected formalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 54 breast cancer patients treated with radiation after breast-conserving surgery and identified comprehensive molecular information in hundreds of cancer-associated genes by FoundationOne CDx (F1CDx), a next-generation sequencing (NGS)-based assay.ResultsAmong our cohort of 54 breast cancer patients, we found high-frequency mutations in cancer-related genes such as TP53 (56%), RAD21 (39%), PIK3CA (35%), ERBB2 (24%), and MYC (22%). Strikingly, we detected that the WNT pathway appears to be a signaling pathway with specific high-frequency mutations in the HER2 subtype. We also compared the mutation frequencies of the two groups of patients with and without cutaneous radiation injury (CRI) after radiotherapy and found that the mutation frequencies of two genes, FGFR1 and KLHL6, were significantly higher in patients with CRI : No subgroup than in those with CRI : Yes.ConclusionDifferent breast cancer subtypes have their own type-specific mutation patterns. FGFR1 and KLHL6 mutations are protective factors for radiation-induced skin toxicity in breast cancer patients.
Prevalence and clinical significance of potential drug-drug interactions among lung transplant patients
Authors: Zhang Jiali , Ma Danyi , Chen Meng , Hu Yanting , Chen Xveying , Chen Jingyu , Huang Man , Dai Haibin 
Published: February 2024

Background: Drug-drug interactions (DDIs) are a major but preventable cause of adverse drug reactions. There is insufficient information regarding DDIs in lung transplant recipients.Objective: This study aimed to determine the prevalence of potential DDIs (pDDIs) in intensive care unit (ICU) lung transplant recipients, identify the real DDIs and the most frequently implicated medications in this vulnerable population, and determine the risk factors associated with pDDIs.Methods: This retrospective cross-sectional study included lung transplant recipients from January 2018 to December 2021. Pertinent information was retrieved from medical records. All prescribed medications were screened for pDDIs using the Lexicomp® drug interaction software. According to this interaction software, pDDIs were classified as C, D, or X (C = monitor therapy, D = consider therapy modification, X = avoid combination). The Drug Interaction Probability Scale was used to determine the causation of DDIs. All statistical analysis was performed in SPSS version 26.0.Results: 114 patients were qualified for pDDI analysis, and total pDDIs were 4051. The most common type of pDDIs was category C (3323; 82.0%), followed by D (653; 16.1%) and X (75; 1.9%). Voriconazole and posaconazole were the antifungal medicine with the most genuine DDIs. Mean tacrolimus concentration/dose (Tac C/D) before or after co-therapy was considerably lower than the Tac C/D during voriconazole or posaconazole co-therapy (p &lt; 0.001, p = 0.027). Real DDIs caused adverse drug events (ADEs) in 20 patients. Multivariable logistic regression analyses found the number of drugs per patient (OR, 1.095; 95% CI, 1.048–1.145; p &lt; 0.001) and the Acute Physiology and Chronic Health Evaluation II (APACHE Ⅱ) score (OR, 1.097; 95% CI, 1.021–1.179; p = 0.012) as independent risk factors predicting category X pDDIs.Conclusion: This study revealed a high incidence of both potential and real DDIs in ICU lung transplant recipients. Immunosuppressive drugs administered with azole had a high risk of causing clinically significant interactions. The number of co-administered drugs and APACHE Ⅱ score were associated with an increased risk of category × drug interactions. Close monitoring of clinical and laboratory parameters is essential for ensuring successful lung transplantation and preventing adverse drug events associated with DDIs.
Who counts as diverse? The strategic broadening and narrowing of diversity
Authors: Zhang Junming , Kirby Teri A. 
Published: February 2024

IntroductionA large majority of US organizations profess a commitment to diversity, but their definitions of diversity can vary greatly. While previous research demonstrates a shift in diversity definitions to include fewer protected demographic groups and more non-demographic characteristics, the present research examines whether this shift might be a motivated process among dominant group members related to anti-egalitarian and colorblind belief systems.MethodsUsing quantitative and qualitative methods, we explored potential underlying ideologies that may be associated with White Americans’ shifting definitions of diversity. White Americans (N = 498) were asked how they define diversity, as well as who should be included in a range of diversity initiatives.ResultsWhite participants’ higher anti-egalitarian belief was associated with stronger colorblind ideology endorsement, which was then associated with shifting their definition of diversity to include fewer disadvantaged demographic groups, more advantaged demographic groups, and non-demographic groups, as well as employing a colorblind inclusion rhetoric.DiscussionInstead of only “broadening” diversity to include more characteristics than diversity’s original focus, White Americans higher in anti-egalitarian and colorblind motives exhibited a simultaneous “narrowing” of diversity to include fewer protected demographic characteristics. Taken together, these findings have implications for dominant group members’ definition of diversity and the subtle ways in which colorblind ideology may be enacted.
An investigation of the associations between stigma, self-compassion, and pain outcomes during treatment based on Acceptance and Commitment Therapy for chronic pain
Authors: Anderson Madeleine , McCracken Lance M. , Scott Whitney 
Published: February 2024

IntroductionStigma adversely affects people with chronic pain. The qualities within self-compassion may be particularly useful for buffering the impact of stigma on people with pain. In the context of an Acceptance and Commitment Therapy-based (ACT) treatment for chronic pain, this study investigated the association between changes in stigma and self-compassion and pain outcomes, and the potential moderating role of self-compassion on the association between stigma and pain outcomes.Materials and methodsFive-hundred and nineteen patients completed standardized self-report questionnaires of stigma, self-compassion, psychological flexibility, pain intensity and interference, work and social adjustment, and depression symptoms at the start of an interdisciplinary ACT-based treatment for chronic pain. The same measures were completed at post-treatment (n = 431).ResultsThe results indicated that key pain outcomes and self-compassion significantly improved during treatment, but stigma did not. Changes in stigma and self-compassion were significantly negatively correlated and changes in these variables were associated with improvements in treatment outcomes. There were significant main effects of stigma and self-compassion for many of the pre- and post-treatment regression models when psychological flexibility was not controlled for, but self-compassion did not moderate the association between stigma and pain outcomes. Stigma remained significant when psychological flexibility variables were controlled for, while self-compassion did not.DiscussionThe findings add to our conceptual understanding of the inter-relationships between stigma, self-compassion, and psychological flexibility and can contribute to treatment advancements to optimally target these variables.
Body shaming and internalized weight bias as potential precursors of eating disorders in adolescents
Authors: Cerolini Silvia , Vacca Mariacarolina , Zegretti Anna , Zagaria Andrea , Lombardo Caterina 
Published: February 2024

IntroductionBody shaming (BS) is a growing phenomenon within the school context, especially among adolescents. Recently, it has been described as an unrepeated act in which a person expresses unsolicited, mostly negative comments about an individual’s body. The targeted person perceives these comments as negative, offensive or body shame-inducing. Empirical evidence also suggests that body weight is the most common reason that youths are teased and bullied. Indeed, weight stigma, described as bias or discriminatory behaviors, attitudes, feelings, and thinking about individuals, because of their weight, can lead to weight-based discrimination and victimization. Preliminary evidence suggests that BS and weight stigma have negative effects on psychological health both in the short and long term. In the delicate stage of adolescence development and pubertal maturation, BS experiences can be highly prevalent and it can lead to adverse outcomes such as eating disorders (ED). However, prevalence data in the Italian context are still lacking.MethodsThe study aims to estimate weight-related BS perceived by different sources (i.e., peers and family members) and their associations with public and internalized weight bias, body mass index (BMI), body dissatisfaction, and ED symptoms. A sample of 919 high school students (Mage = 15.97, SD = 1.58; 57.1% boys) completed a battery of self-report questionnaires assessing these variables.ResultsOne in four students reported experiences of weight-related BS by peers or family members. A total of 37% reported having at least one BS experience in a lifetime. Higher scores of ED symptoms, body dissatisfaction, and weight bias were reported by adolescents who experienced BS, especially females. Among overweight participants, results showed that internalized weight bias partially mediated the relationship between BS by family members and ED symptoms and fully mediated the relationship between BS by peers and ED symptoms, after controlling for age, sex and BMI.DiscussionThese findings, despite their cross-sectional nature, add an important contribution to the creation of quantitative empirical evidence on the phenomenon of BS. Its role in explaining eating disorders, both alone and with the mediation of internalized weight stigma has been first proved and needs to be confirmed by longitudinal results.
Valuable interaction with cognitive remediation and optimal antipsychotics for recovery in schizophrenia (VICTORY-S): study protocol for an interventional, open-label, randomized comparison of combined treatment with cognitive remediation and lurasidone or paliperidone
Authors: Kubota Ryotaro , Ikezawa Satoru , Oi Hideki , Oba Mari S , Izumi Shoki , Tsuno Ryoko , Adachi Leona , Miwa Mako , Toya Shunji , Nishizato Yohei , Haga Daisuke , Iwane Tatsuro , Nakagome Kazuyuki 
Published: February 2024

BackgroundCognitive impairment, a core feature of schizophrenia, is associated with poor outcomes. Pharmacotherapy and psychosocial treatment, when used alone, have inadequate effect sizes for cognitive impairment, leading to recent interest in combination interventions. A previous study examined the additive effect of cognitive remediation on lurasidone in patients with schizophrenia, which was negative. Although improvement in cognitive function was suggested for lurasidone, it was inconclusive because there was no antipsychotic control in the study. To clarify whether lurasidone has a meaningful impact on cognitive function in combination with cognitive remediation, we use paliperidone as a control antipsychotic in this study. We hypothesize that combination with lurasidone will improve cognitive and social function to a greater extent than paliperidone.MethodsThe valuable interaction with cognitive remediation and optimal antipsychotics for recovery in schizophrenia study is a multicenter, interventional, open-label, rater-blind, randomized comparison study, comparing the effect of lurasidone plus cognitive remediation with that of paliperidone plus cognitive remediation in patients with schizophrenia. The Neuropsychological Educational Approach to Remediation (NEAR) is used for cognitive remediation. Eligible patients will be randomized 1:1 to receive lurasidone or paliperidone combined with NEAR (6 weeks antipsychotic alone followed by 24 weeks combination antipsychotic plus NEAR). The primary endpoint is the change from baseline in the tablet-based Brief Assessment of Cognition in Schizophrenia composite T-score at the end of the NEAR combination treatment period. Secondary endpoints will include change from baseline in social function, schizophrenia symptoms, and quality of life at the end of the NEAR combination treatment period. Furthermore, change from baseline to the end of the pharmacotherapy period and change from the end of the pharmacotherapy period to the end of the NEAR combination treatment period will be assessed for all endpoints. Safety will also be evaluated.DiscussionAchievement of adequate cognitive function is central to supporting social function, which is a key treatment goal for patients with schizophrenia. We think this study will fill in the gaps of the previous study and provide useful information regarding treatment decisions for patients with schizophrenia.Clinical trial registrationJapan Registry of Clinical Trials ID, jRCTs031200338.
The protective role of phlorizin against lipopolysaccharide-induced acute orchitis in mice associated with changes in gut microbiota composition
Authors: Guo Qing , Li Tian-Feng , Huang Jiang , Li Jing-Chun , Zhang Ze-Cai , Qu Yong-Li 
Published: February 2024

ObjectiveOrchitis is a common reproductive disease of male animals, which has serious implications to human and animal reproduction. Additionally, phlorizin (PHN), a common polyphenol in apples and strawberries, has a variety of biological activities, including antioxidant, anti-inflammatory, anti-diabetic, and anti-aging activities. We aimed to determine the protective effects and potential mechanisms of PHN in lipopolysaccharide (LPS)-induced acute orchitis in mice.MethodAfter 21 days of PHN pretreatment, mice were injected with LPS to induce testicular inflammation, and then the changes of testicular tissue structure, expression of inflammatory factors, testosterone level, expression of testosterone-related genes, adhesion gene and protein expression were detected, and the structural changes in the intestinal flora after PHN treatment were further detected by 16SRNA.ResultOur results demonstrated that PHN treatment reduced LPS-induced testicular injury and body and testicular weight losses. The mRNA expression levels of pro-inflammatory cytokines-related genes and antioxidant enzyme activity were also decreased and elevated, respectively, by PHN administration; however, PHN treatment also reduced the LPS-induced decrease in testosterone levels in the testes. Additionally, further studies found that PHN increased the expression of marker proteins zonula occludens-1 (ZO-1) and occludin associated with the blood testosterone barrier compared with that in LPS treatment groups. To further examine the potential mechanisms of the protective effect of PHN on LPS-induced testicular injury, we compared the differences of gut microbiota compositions between the 100 mg/kg PHN treatment group and the control group using 16SRNA. Metagenomic analyses indicated that the abundances of Bacteroidetes, Muribaculaceae, Lactobacillaceae, uncultured bacterium f Muribaculaceae, and Lactobacillus in the PHN treatment group improved, while potential microbes that can induce intestinal diseases, including Verrucomicrobia, Epsilonbacteraeota, Akkermansiaceae, and Akkermansia decreased in the PHN treatment group.ConclusionOur results indicate that PHN pretreatment might alleviate orchitis by altering the composition of gut microflora, which may provide a reference for reducing the occurrence of acute orchitis in male animals.
Bacterial Endophytes from Legumes Native to Arid Environments Are Promising Tools to Improve Mesorhizobium–Chickpea Symbiosis under Salinity
Authors: Ben Gaied Roukaya , Sbissi Imed , Tarhouni Mohamed , Brígido Clarisse 
Published: February 2024

Symbiotic nitrogen fixation is a major contributor of N in agricultural ecosystems, but the establishment of legume–rhizobium symbiosis is highly affected by soil salinity. Our interest is focused on the use of non-rhizobial endophytes to assist the symbiosis between chickpea and its microsymbiont under salinity to avoid loss of production and fertility. Our aims were (1) to investigate the impact of salinity on both symbiotic partners; including on early events of the Mesorhizobium-chickpea symbiosis, and (2) to evaluate the potential of four non-rhizobial endophytes isolated from legumes native to arid regions (Phyllobacterium salinisoli, P. ifriqiyense, Xanthomonas translucens, and Cupriavidus respiraculi) to promote chickpea growth and nodulation under salinity. Our results show a significant reduction in chickpea seed germination rate and in the microsymbiont Mesorhizobium ciceri LMS-1 growth under different levels of salinity. The composition of phenolic compounds in chickpea root exudates significantly changed when the plants were subjected to salinity, which in turn affected the nod genes expression in LMS-1. Furthermore, the LMS-1 response to root exudate stimuli was suppressed by the presence of salinity (250 mM NaCl). On the contrary, a significant upregulation of exoY and otsA genes, which are involved in exopolysaccharide and trehalose biosynthesis, respectively, was registered in salt-stressed LMS-1 cells. In addition, chickpea co-inoculation with LMS-1 along with the consortium containing two non-rhizobial bacterial endophytes, P. salinisoli and X. translucens, resulted in significant improvement of the chickpea growth and the symbiotic performance of LMS-1 under salinity. These results indicate that this non-rhizobial endophytic consortium may be an appropriate ecological and safe tool to improve chickpea growth and its adaptation to salt-degraded soils.
Ground Resistance Estimation for a DC Converter Station: Theory versus Experiment
Authors: Akef Samar , El-Morshedy Ahdab M. K. , Samy Mohamed M. , Emam Ahmed M. , El-Hawary Hadeer H. 
Published: February 2024

This paper is aimed at proposing a calculation model for the ground resistance of a grounding scheme servicing a high-voltage direct-current converter station. The method is based on the equivalence of current conduction and electric field from the grounding scheme through the surrounding medium. The grounding scheme is composed of three concentric ring electrodes supported by two horizontal conductors and eight vertical rods. The calculated ground resistance is 4.8 Ω against the experimental value of 5 Ω with an error of 4.2%. The calculated ground resistance value agrees reasonably well with that of 4.7 Ω as obtained using CYMGRD software (version 7.0). The calculated surface-potential values over the ground surface agreed reasonably well with those measured experimentally, with an average deviation not exceeding 6.5%. This study is designed to investigate how ground resistance is decreased by the increase in the scheme parameters, including the rods’ diameter and length, as well as the radius of the inner and outer rings. The dependency of the ground resistance on the soil type is also investigated.
THE ANTIBACTERIAL ACTIVITY OF GLYCOLIPOPEPTIDE PRODUCED FROM LACTOCOCCUS LACTIS HN21 AGAINST SOME CLINICAL PATHOGENS IN COMBINED WITH SOME STANDARD ANTIBIOTICS
Authors: Hala. M. A  , N. H. Haider  
Published: February 2024

This study was aimed to produce a biosurfactant from Lactococcus sp. and study its synergistic effects with some standard antibiotics. Lactococcus sp. HN21 isolate was selected for its highly biosurfactant production and antibacterial activity. It was identified by 16s r RNA as Lactococcus lactis HN21. Optimum conditions for production were studied and it was: Modified M17 media (M17 media with some modifications in its composition) at ph 6.5, for 96 hrs incubation time. The E24% at these conditions was 77%. FTIR and GC-MS results identified the produced biosurfactant as glycolipopeptide with a major fatty acid octadecenoic acid. P. aeruginosa was successfully inhibited by the glycolipopeptide alone, with overall inhibition ranging from (15 to 19 mm). The combined use of antibiotics and glycolipopeptide, however, resulted in an increase in the total inhibition zones to (17 to 28 mm), while glycolipopeptide alone was effective against S. aureus and showed total inhibition zones ranging from (15 to 22) mm. glycolipopeptide in combination with antibiotics, the total inhibition zones were increased (26 to 40) mm. The results observed a great pharmaceutical application in increasing the bactericidal effect.
Cappella a Unterliezheim, Germania
Authors: Butini Riccardo 
Published: February 2024

La cappella appare come un ‘oggetto trovato’ e intrattiene un intenso dialogo con il contesto che la accoglie, mostrando un’inattesa capacita di ‘radicamento’; un legame stretto, sospeso tra dimensione trascendente dello spazio naturale e quella razionale della precisa tecnica costruttiva, che dall’esterno prosegue, sublimandosi, all’interno.
The chapel appears as a 'found object' and carries out an intense dialogue with the context in which it is located, demonstrating an unexpected capacity for 'enrootment'; a close connection, suspended between the transcendent dimension of natural space and the rationality of a precise building technique, that of the exterior which proceeds, through sublimation, into the interior.
Terzo Atto a Palazzo Ducale: il Venice Cycle di Anselm Kiefer
Authors: Eccheli Maria Grazia 
Published: February 2024

L’opera di Kiefer Venice Cycle è il terzo atto di una eterna ri-scrittura del Palazzo Ducale di Venezia. Pensata e misurata per la Sala dello Scrutinio, luogo deputato dell’elezione dei dogi, essa è un magnifico «solstizio veneziano», una pausa del cammino del sole a catturare la sospensione dello spazio e del tempo dentro il vortice della storia.
Kiefer’s Venice Cycle is the third act in an eternal re-writing of the Doge’s Palace in Venice. Conceived and proportioned for the Sala dello Scrutinio, the place where doges were elected, it is a magnificent “Venetian solstice”, a pause in the sun’s path to capture the suspension of space and time within the vortex of history.