bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПСИХОЛОГО-ПЕДАГОГІЧНІ ЗАСАДИ МОДЕЛЮВАННЯ СИСТЕМИ ВИЩОЇ ОСВІТИ УКРАЇНИ В УМОВАХ ЇЇ ПАРАДИГМАЛЬНОЇ КРИЗИ
Authors: Лузік Ельвіра , Кокарєва Анжеліка 
Published: December 2023

Стаття присвячена ґрунтовному науково-теоретичному аналізу праць вітчизняних та зарубіжних вчених щодо побудови психологичних засад моделювання системи вищої освіти в інформаційно-освітньому середовищі закладів вищої технічної освіти України.
Мета дослідження полягала у концептуалізаціі і операціоналізації психолого-педагогічних засад моделювання системи вищої освіти ЗВТО в умовах парадигмальної кризи.
Завдання дослідження зосереджено на визначенні теоретичних підходів до вивчення проблеми моделювання системи вищої технічної освіти в інформаційно-освітньому середовищі ЗВТО України в умовах її парадигмальної кризи і диверсифікації вищої професійної освіти; визначенні системоутворюючого принципу психолого-педагогічних засад моделювання системи вищої освіти в рамках гуманістичної парадигми, що забезпечують прогноз і досягнення ефективності функціонування системи в проекції цілей всіх зацікавлених учасників освітнього процесу у ЗВТО. Для досягнення поставленої мети були використані наступні методи дослідження: науковий аналіз; систематизація; узагальнення, педагогічне та математичне моделювання з використанням факторного аналізу.
Результати. У процесі проведеного дослідження було доведено, що застосування моделювання системи вищої освіти на психологічних засадах в ситуації її реформування дозволяє вирішити основні парадигмальні протиріччя у вітчизняній психолого-педагогічній теорії засобами інтерпретаційних схем функціонування і перетворення вищої школи: між ціннісними установками диверсифікації системи вищої технічної освіти, з одного боку, і цілями та засобами її реалізації – з іншого.
Висновки. Встановлено, що психолого-педагогічними засадами моделювання системи вищої освіти виступають комунікативний підхід як система методологічних засобів, що забезпечують вирішення «протиріччя зустрічі» нормативної та гуманістичної парадигм; інтерпретація цілей (відповідно, критеріїв ефективності або системо утворюючих принципів) функціонування і перетворення системи вищої професійної освіти (ВПО) в рамках гуманістичної парадигми, тобто з позиції всіх зацікавлених учасників освітнього процесу у ЗВТО і ситуації працевлаштування, які визначають обмеження моделі системи вищої освіти. Системоутворюючим принципом моделювання системи ВПО, визначаючим її обмеження, виступає концепт компетентності в рамках гуманістичного підходу, який визначається як стан і рефлексивний механізм досягнення ситуативної релевантності та особистісної ідентичності суб’єкта в контексті професійного становлення
Determination of Profit Falah Based on Sharia Financing at Sharia Commercial Banks in Indonesia
Authors: Muthaher Osmad , Wahyundaru Sri Dewi , Adiwijaya Zaenal Alim 
Published: December 2023

The purpose of this study is to examine the factors that influence Profit Falah in the Islamic banking industry in Indonesia. The population in this study is all Islamic banking industries in Indonesia that issued financial statements between 2017 – 2020. The sample method used is a purposive sampling method that does not lose, with the number of selected samples as many as 60 sample data. Data was collected from the website of Bank Stariah in Indonesia. The results of the t-test calculation show mixed findings on the variables of the principle of profit sharing, murabahah financing, and the principle of ijarah to Profit Falah. Variable profit-sharing financing and Murabahah have a significant positive influence on Profit Falah,. However, the principle of ijarah, which involves lease transactions, shows an in significant negative influence on Profit Falah.
Conflict of Interest: An Epidemic Dilemma Within the South African Public Procurement System
Authors: Zitha H.E. , Mathebula N.E. 
Published: December 2023

Background: Challenges of the South African public procurement system continues unabated to make visible footprints in the yearly Auditor-General’s reports. At the centre of the challenges is the failure to comply with the legislative framework regulating public procurement resulting in irregular expenditure. Compliance failures are at the root of evil deeds and misconduct in the South African public sector.Setting: The existence of a plethora of legislative frameworks, polices and standard operating procedures and the yearly reports of the Auditor-General leaves one pondering in relation to the difficulty for procurement officials to adhere to these prescripts. Aim: It against this notion that this conceptual paper gives an analysis of the impact of conflict of interests as suspect in chief on failure by procurement officials to adhere on procurement regulations. Of essence is to examine causal factors and inherent consequences which in most instances is conflicting interest by public officials.Method: This paper analyses secondary data with regard to conflict of interest with in the South African public procurement system. This is done by means of literature and government documentation.Conclusion: This paper concludes that the concept of conflict of interest is not new within the procurement space, yet procurement officials still grapple on how to effectively deal with it whenever it arises. This therefore calls for reform in procurement processes especially in ensuring consequentialism for wrongdoers.Contribution: The paper contributes towards the shaping of public procurement policies and ethical guidelines in all spheres of government. This paper further contributes to the body of knowledge considering that it will unearth critical dimensions of conflict of interests particularly for the public sector.
Analysis of the thermal effect of two external parallel printed circuit board conductors set on a metal base and operating in a space vacuum on each other
Authors: Kostin Aleksey V. 
Published: December 2023

Background. The need to analyze the thermal effect of two external parallel conductors is due to an increase in the density of the conductive pattern. For printed circuit boards set on a metal base and operating in the vacuum of space, this need is aggravated by the weakness of the issue's development.
Aim. Analysis of the mutual influence of two external parallel printed circuit board conductors set on a metal base and operating in a space vacuum on each other to identify the dependence of their temperature on the distance between them and determine the distance at which this dependence practically disappears.
Methods. To achieve the purpose, a finite element method calculation implemented in the ANSYS program, the Steady-State Thermal module, was used. Three multilayer printed circuit boards were calculated: 4-layer, 6-layer, 8-layer. The temperature coefficient of resistance was taken into account separately, by recalculation.
Results. Graphs of the dependence of overheating (the difference between the temperature of the printed conductor and the metal base) on the distance between the printed conductors were constructed. The approximation of the obtained results is carried out. According to the approximated dependencies, the minimum values of the distances between printed conductors are found, at which the cross influence of printed conductors practically disappears. As the thickness of the printed circuit board increases, this distance increases.
Conclusion. The results obtained can help to assess the influence of neighboring printed conductors in the design of the boards of the onboard equipment of spacecraft.
Hall Professionalism Scale (HPS) Sebagai Alat Ukur Tingkat Profesionalisme Pembimbing Kemasyarakatan di Balai Pemasyarakatan DKI Jakarta
Authors: Waskito Akhmad Maulana , Jarodi Odi 
Published: December 2023

Penelitian ini bertujuan untuk mengukur Tingkat Profesionalisme Pembimbing Pemasyarakatan di Balai Pemasyarakatan DKI Jakarta. Dalam peneletian ini menggunakan metode Hall Profesionalism Scale (HPS). Dalam penelitian ini menggunakan metode kuantitatif deskriptif dengan sampel yang diambil menggunakan rumus krejcie dan morgan. Dari total sampel tersebut dibagi kembali menjadi sub sampel dengan metode stratified random sampling yang pada akhirnya total sampel yang digunakan sebanyak 143 responden. Dari penelitian ini didapatkan rata-rata dari keseluruhan dimensi profesionalisme sebesar 573,85 dengan tingkat persentase sebesar 80,26%. Hasil analisa deskriptif menunjukkan bahwa tingkat profesionalisme pembimbing kemasyarakatan di Balai Pemasyarakatan DKI Jakarta dalam kategori baik.
Hybrid GA–DeepAutoencoder–KNN Model for Employee Turnover Prediction
Authors: LIM CHIN SIANG , MALIK ESRAA FAISAL , KHAW KHAI WAH , ALNOOR ALHAMZAH , CHEW XINYING , CHONG ZHI LIN , Al Akasheh Mariam 
Published: December 2023

Organizations strive to retain their top talent and maintain workforce stability by predicting employee turnover and implementing preventive measures. Employee turnover prediction is a critical task, and accurate prediction models can help organizations take proactive measures to retain employees and reduce turnover rates. Therefore, in this study, we propose a hybrid genetic algorithm–autoencoder–k-nearest neighbor (GA–DeepAutoencoder–KNN) model to predict employee turnover. The proposed model combines a genetic algorithm, an autoencoder, and the KNN model to enhance prediction accuracy. The proposed model was evaluated and compared experimentally with the conventional DeepAutoencoder–KNN and k-nearest neighbor models. The results demonstrate that the GA–DeepAutoencoder–KNN model achieved a significantly higher accuracy score (90.95\%) compared to the conventional models (86.48% and 88.37% accuracy, respectively). Our findings are expected to assist HR teams identify at-risk employees and implement targeted retention strategies to improve the retention rate of valuable employees. The proposed model can be applied to various industries and organizations, making it a valuable tool for HR professionals to improve workforce stability and productivity.
ZNF148/PFKP/PD-L1 axis promotes non-small cell lung cancer proliferation, migration and glycolysis
Authors: Zhu Jialiang , Chen Yufan , Jin Longyu , Feng Wei , Hu Huaidong , Xue Wenbo , Zhou Zhigang , Luo Guangyu 
Published: December 2023

Aim: Cancer-related deaths are primarily caused by lung cancer around the world. The prognosis and burden of lung cancer must be improved by identifying novel biomarkers for diagnosis and treatment. In non-small cell lung cancer (NSCLC), the platelet isoform of phosphofructokinase 1 (PFKP) has been identified as a tumor-promoting oncogene. The current study examined the specific role that PFKP plays in NSCLC tumorigenesis, as well as the underlying mechanism.
Methods: A lung cancer dataset was obtained from the TCGA in order to examine the expression of PFKP. Using the Kaplan-Meier Plotter website, we calculated the overall survival (OS) along with the recurrence-free survivals (RFS) curves with high and low levels of PFKP in lung cancer. The mechanism by which zinc finger protein 148 (ZNF148) regulated PFKP/PD-L1 levels in NSCLC was investigated through chromatin immunoprecipitation (ChIP), qRT-PCR, and western blotting. In order to uncover ZNF148's function in NSCLC, subsequent functional studies included CCK-8, colony formation, and Transwell, along with glycolysis assays. Student’s T-test was conducted for data analysis with GraphPad Prism 9.0.
Results: The expression of PFKP in NSCLC was increased, and it was linked to worse outcomes. This increased expression of PFKP in NSCLC was induced by ZNF148. Silencing ZNF148 remarkably dampened NSCLC cell proliferation, invasion, and glycolysis capacities. According to a mechanistic study, ZNF148 regulates the PFKP/PD-L1 axis, which promotes NSCLC tumorigenesis.
Conclusion: It has been established that ZNF148-induced PFKP is key to the proliferation, invasion, and glycolysis abilities of NSCLC cells by regulating PD-L1 expression. Therefore, the ZNF148/PFKP/PD-L1 axis could be a potential biological signature and target for NSCLC diagnosis and treatment.
Surgery for Vertebral Osteomyelitis Lowers 1-Year Mortality and Failure Rates Compared with Nonsurgical Treatment
Authors: Kernich Nikolaus , Sircar Krishnan , Jochimsen Dorothee , Walter Sebastian Gottfried , Eysel Peer , Jung Norma , Yagdiran Ayla , Weber Carolyn 
Published: December 2023

Background:
The aim of this study was to determine differences between patients who underwent surgical treatment and those who underwent nonsurgical treatment of vertebral osteomyelitis (VO) and to identify potential factors influencing treatment failure (death and/or recurrence within 1 year).

Methods:
We performed a retrospective analysis of clinical data prospectively collected from patients treated for VO between 2008 and 2020. The decision between surgical and nonsurgical treatment was made for each patient based on defined criteria. A 1:1 propensity score matching was performed to exclude confounders between the 2 treatments. Univariate and multivariable analyses were performed to identify potential risk factors for death and/or recurrence within the first year after VO diagnosis.

Results:
Forty-two patients (11.8%) were treated nonsurgically and 313 patients (88.2%) underwent surgery. A higher percentage of the surgically treated patients than the nonsurgically treated patients had an American Society of Anesthesiologists score of >2 (69.0% versus 47.5%; p = 0.007), and the thoracic spine was affected more often in the surgical group (30.4% versus 11.9%; p = 0.013). Endocarditis was detected significantly more often in the nonsurgically treated patients (14.3% versus 4.2%; p = 0.018). The recurrence rate was 3 times higher in the nonsurgically treated patients (16.7% versus 5.4%; p = 0.017), but this difference was no longer detectable after propensity matching. After matching, the nonsurgically treated patients showed an almost 7-fold higher 1-year mortality rate (25.0% versus 3.7%; p = 0.018) and an almost 3-fold higher rate of treatment failure (42.9% versus 14.8%; p = 0.022). Multivariable analysis revealed nonsurgical treatment and bacteremia to be independent risk factors for treatment failure.

Conclusions:
In our matched cohort of patients with VO, surgical intervention resulted in a significantly lower rate of treatment failure (death and/or recurrence within 1 year) compared with nonsurgical intervention. Furthermore, nonsurgical treatment was an independent risk factor for treatment failure.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
OTUB1/ NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death
Authors: Huang Xiaodong , li Du , Xiao-Chen Cheng , Yu-Xin Lu , Qiao-Wei Liu , Wang Yiwu , Liao Yajin , Dong-Dong Lin , Feng-Jun Xiao 
Published: December 2023

Abstract

Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis.Our previous study reveals that NDUFS2 (NADH: ubiquinone oxidoreductase core subunit S2), a core subunit of the mitochondrial respiratory chain complex I, is unregulated in Pancreatic adenocarcinoma (PAAD). However, its role in the development of PAAD remains unknown. Here, we showed that NDUFS2 played a critical role in the survival, proliferation and migration of pancreatic cancer cells by inhibiting mitochondrial cell death. Additionally, bioinformatics analysis in clinical samples indicated that the expression of NDUFS2 was positively correlated with a deubiquitinases, OTUB1. Overexpression of OTUB1 increased NDUFS2 expression at the protein level, while knockdown of OTUB1 restored the effects in vitro. Accordingly, overexpression and knockdown of OTUB1 phenocopied those of NDUFS2 in pancreatic cancer cells, respectively. Mechanically, NDUFS2 was deubiquitinated by OTUB1 via K48-linked polyubiquitin chains, resulted in an elevated protein stability of NDUFS2. Moreover, the growth of NDUFS2-overexpressed pancreatic cancer xenograft tumor was promoted in vivo, while the NDUFS2-silenced pancreatic cancer xenograft tumor was inhibited in vivo. In conclusion, we revealed that OTUB1 increased the stability of NDUFS2 in PAAD by deubiquitination, and this axis plays a pivotal role in pancreatic cancer genesis and development.
Incidence, temporal trends, and socioeconomic aspects of male hypogonadism
Authors: Percik Ruth , Vered Shiraz , Liel Yair 
Published: December 2023

Abstract

Little data exists on temporal changes in the incidence of definite hypogonadism and its correlation with socioeconomic status.
We extracted data from the Maccabi Health Services computerized database between 2001-2017, which includes all electronic health records and laboratory data. The study included 4261 men with biochemically verified hypogonadism defined according to the European Male Study criteria.
Male hypogonadism increased persistently with age in all the socioeconomic strata. 75% of the hypogonadal men had hypogonadotropic hypogonadism (HH). The overall incidence of hypogonadism increased 1.4-fold between the 2001-2009 and 2010-2017 periods, mainly due to an increase in HH. The temporal increase in hypogonadism occurred in all age groups of all socioeconomic strata but was notably more prominent in the >51 age group of the more affluent socioeconomic strata. BMI remained unchanged throughout the study period.
The temporal increase in HH corresponds with previous observations of a temporal decrease in testosterone levels in men of a yet undetermined cause. Hypothetically, both could be linked to an underappreciated association between mental distress due to workplace demands and occupational burnout in specific occupations (i.e., high-tech, finance, medical) associated with more affluent populations, and reflected by decreased global happiness indices. This preliminary proposition deserves further investigation.
Efficacy of paracetamol and mannitol injection in managing chronic post-thoracotomy pain following lung cancer surgery: Study protocol for a single center, prospective, randomized, double-blind, and controlled trial
Authors: Zhou Junhui , Li Xi , Gao Jie , Liu Siqing , Zhong Wei , Xi Gaoyuan , Guo Yinchun , Xu Hongdang 
Published: December 2023

Abstract
Background Chronic post-thoracotomy pain (CPTP) is a common complication after lung cancer surgery, involving 20% to 60% of patients. This persistent pain affects patients' quality of life and satisfaction with surgery. Paracetamol and mannitol injection, known for its analgesic and antipyretic properties, may help relieve moderate-to-severe postoperative pain. This trial aims to assess the effectiveness and safety of paracetamol and mannitol injection in managing CPTP after lung cancer surgery.
Methods This is a prospective, double-blind, randomized controlled clinical trial conducted at a single center. A total of 394 patients scheduled for thoracoscopic radical surgery for lung cancer will be enrolled andrandomly assigned to test group (intravenous infusion of paracetamol and mannitol injection) or control group(intravenous infusion of normal saline) in a 1:1 ratio, with 197 patients in each group. The primary outcome is the incidence of CPTP at 3 months after surgery. Secondary outcomes include the dosage of propofol and remifentanil, numerical rating scale (NRS) pain scores, patient-controlled intravenous analgesia (PCIA) pressing times, the occurrence of postoperative nausea andvomiting, and respiratory depression, time to first flatus and ambulation after surgery, length of hospital stay, surgeon and patient satisfaction, and the incidence of CPTP at 6 and 12 months after surgery. The patient's quality of daily life will be evaluated at 3, 6, and 12 months after the surgery. Intention-to-treat (ITT) analysis will be conducted.
Discussion We hypothesize that the use of intravenous paracetamol and mannitol injection can reduce the incidence and severity of CPTP and improve the quality of daily life. Additionally, the expected rate of adverse reactions from paracetamol and mannitol injection will be low. This trial will assess the effectiveness and safety of paracetamol and mannitol injection in managing CPTP after lung cancer surgery and provide scientific evidence for clinical practice.
Trial Registration Chinese Clinical Trial Registry, Registration number: ChiCTR2300072869, 2023-06-27, https://www.chictr.org.cn/.
Trial Status This trial is currently ongoing. Study execution period: July 1, 2023, to October 1, 2024. Recruiting period: August 1, 2023, to May 1, 2024. Version number and date: Version 1.1 of 08-20-2023
Identification of a ferroptosis-related gene signature for the prognosis of pediatric neuroblastoma
Authors: Lin Xijin , Xie Lanting , Lin Zhuangbin , Shao Kongfeng , Liang Qiandong , Li Xiaoyan , Wu Junxin 
Published: December 2023

Abstract
Background
To establish a prognostic ferroptosis-related gene model for predicting prognostic value in pediatric neuroblastoma (NB) patients.
Methods
The gene expression array and clinical characteristics of NB were downloaded from a public database. Correlations between ferroptosis-related genes and drug responses were analyzed by Childhood Cancer Therapeutics. The prognostic model was constructed by least absolute shrinkage and selection operator (LASSO) Cox regression and was validated in NB patients from the ICGC cohort. The survival analysis was performed by Cox regression analysis. ssGSEA was used to quantify the immune cell infiltration correlation.
Results
Overall, 70 genes were identified as ferroptosis-related DEGs from 247 samples. Then, 13 ferroptosis-related genes were correlated with OS in the univariate Cox regression analysis. Five prognostic ferroptosis-related DEGs (pFR-DEGs) (STEAP3, MAP1LC3A, ULK2, MTOR and TUBE1), which were defined as the intersection of DEGs and prognostic ferroptosis-related genes, were identified and utilized to construct the prognostic signature. The correlation between five pFR-DEGs and drug responses was analyzed, and the box plots indicated that MTOR gene expression was highest, suggesting that MORT expression is related to progressive NB disease. The receiver operating characteristic (ROC) curve showed that the model had moderate predictive power. The survival analysis indicated that the high-risk group had poor overall survival (OS) (p = 2·087×10− 06). Univariate and multivariate analyses identified the risk score as a significant prognostic risk factor (p = 0·003, HR = 1·933). Immune cell infiltration correlation analysis showed that the high-risk group was related to more immune cells.
Conclusions
The present study indicated a difference in ferroptosis-related gene expression between low- and high-risk NB patients. The ferroptosis-related signature could serve as a prognostic prediction tool. Additionally, immune infiltration might play an important role in different risk groups for NB patients.