bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text and History in Qassim Haddad’s Chronicles of Majnun Layla
Authors: Ababneh Sami , Hamdan Yousef 
Published: November 2023

This paper presents an investigation of Qassim Haddad’s Chronicles of Majnun Layla by comparing the text with history, noting how the truth is based on texts rather than actual events. The aim is to show the impact of texts on the formation of Arabic poetry at the end of the last century. This research stems from the idea that a poet’s work is based on a purely mental experience that results from reading texts, and the contemplation of the human subject and the nature of its feelings and thoughts, as well as the fact that the truth the poet seeks to embody, as is the case with Qassim Haddad, is related to the mental and emotional state rather than real experience. From this standpoint, the work of Qassim Haddad is interpreted as his wanting to correct what was reported about Majnun Layla; in so doing, he compares the value of this information with the ability to express the human condition, indicating that what happened in history was relevant only in so far as the state of mind produced by this case of love and passion was achieved.
The paper consists of three sections. The first is the textuality of the historical story—the historical version is only texts that do not represent historical truth. The second is the text and the historical subjects, which, in the information about Majnun Layla, are nothing but a linguistic textual form and as such their existence in history is unimportant. The third is language and truth; in reading the language in Chronicles of Majnun Layla, it can be seen that it over-stresses the significance of referring to a mental content that embodies the abstract idea of human love without restricting it to a single historical situation.
Mindful minds and entrepreneurial spirits in higher education: a scoping review
Authors: Karali Nansy , Mastrokoukou Sofia , Livas Christos 
Published: November 2023

IntroductionMindfulness at Higher Education Institutions (HEIs) may enhance personal development, learning, and entrepreneurial thinking. Thus, this scoping review investigates the effects of mindfulness on HEI entrepreneurship education, focusing on teaching, learning, and entrepreneurial intention.MethodTo identify relevant articles for inclusion, the study used a predetermined set of keywords and a descriptive search algorithm in six electronic databases. The process of study selection adhered to the principles outlined in the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and resulted in the inclusion of eleven (11) studies. Said studies spanned several nations and employed various research methods, with an emphasis on quantitative approaches.ResultsResults indicated that mindfulness did not have a direct impact on lecturers’ commitment to teaching entrepreneurship. Nevertheless, mindfulness appeared to indirectly impact teaching outcomes by influencing other variables, such as readiness for change. From an educational processes and outcomes perspective, mindfulness was found to improve the entrepreneurship learning environment and enhance students’ entrepreneurial orientation. The latter included students’ intentions to develop or participate in environmental and socially responsible entrepreneurial ventures.DiscussionThe present study advances our understanding of the relationship between mindfulness, entrepreneurship teaching and students’ entrepreneurial orientation in higher education settings. Nevertheless, it also demonstrates a lack of comprehension of the exact mechanisms at play, and therefore highlights the need for further research in this scientific area. By gaining a broader awareness of the impact of mindfulness on entrepreneurship education, education professionals and decision-makers can improve the design of programmes to cultivate the entrepreneurial orientation and skills necessary for students’ success in a rapidly changing business environment.Systematic Review RegistrationThe review process has been duly registered with the Open Science Framework (OSF) and given the identifier DOI 10.17605/OSF.IO/YJTA3.
Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells
Authors: Zheng Rui , Chen Yuankun , Zhang Yiting , Liang Sixin , Zhao Xiaojuan , Wang Yiyi , Wang Pengju , Meng Ruotong , Yang Angang , Yan Bo 
Published: November 2023

IntroductionChimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors, and each component plays an important role in the function and anti-tumor efficacy. It has been reported that using human sequences or a low affinity of CAR single-chain variable fragments (scFvs) in the CAR binding domains is a potential way to enhance the function of CAR-T cells. However, it remains largely unknown how a lower affinity of CARs using humanized scFvs affects the function of CAR-T cells until recently.MethodsWe used different humanized anti-HER2 antibodies as the extracellular domain of CARs and further constructed a series of the CAR-T cells with different affinity.ResultsWe have observed that moderately reducing the affinity of CARs (light chain variable domain (VL)-based CAR-T) could maintain the anti-tumor efficacy, and improved the safety of CAR therapy both in vitro and in vivo compared with high-affinity CAR-T cells. Moreover, T cells expressing the VL domain only antibody exhibited long-lasting tumor elimination capability after multiple challenges in vitro, longer persistence and lower cytokine levels in vivo.DiscussionOur findings provide an alternative option for CAR-T optimization with the potential to widen the use of CAR T cells.
Increased vertebral canal diameter measured by ultrasonography as a sign of vasculitis in patients with giant cell arteritis
Authors: Ayo-Martin Oscar , Garcia-Garcia Jorge , Hernandez-Fernandez Francisco , Palao Maria , Poyatos-Herraiz Beatriz , Barahona-Espinal Tito Humberto , Gonzalez-Romero Alberto , Marin-Conesa Ester , Serrano-Serrano Blanca , Paya Maria , Segura Tomas 
Published: November 2023

IntroductionThe diagnosis of giant cell arteritis (GCA) by ultrasonography including large vessels, apart from the temporal artery increases the sensibility of the study and informs about the risk of specific complications. However, there is less information about the study of these arteries, whose affection carries higher proportion of severe complications.ObjectivesTo describe and analyze the value of the diameter of the cervical vertebral canal of the vertebral artery (VA) as a sign of vertebral vasculitis (VV) related to GCA and estimate the risk of stroke complications.Materials and methodsObservational study of a population that includes patients with GCA with and without VA vasculitis as well as healthy subjects. We evaluated whether there were differences in VA diameter in the groups and, if so, we estimated the diagnostic capacity of the variable that best defines VA diameter using a ROC curve. Cut-off points with their associated reliability chosen thereafter.ResultsThere were 347 subjects included:107 with GCA of whom 37 had vertebral vasculitis, 240 healthy controls. In patients with GCA and VV, the VA diameter was increased (No GCA 3.4 mm, GCA without VV 3.6 mm, GCA with VV 5.2 mm p &lt; 0.01). According to the ROC curves, the variable defining vertebral diameter with best diagnostic accuracy is the sum of both sides (area under the curve of 0.98). With a cut-off point of 8.45 mm, the reliability values are: sensitivity 94.1%, specificity 94.5%, PPV 82.1% and NPV 98.4%. With a cut-off point of 9.95 mm, the sensitivity is 52.9% and the specificity is 100%. Likewise, VA diameter is independently associated with the presence of stroke in the vertebrobasilar territory (OR 1.6, range 1.2–2.2).ConclusionThe VA diameter, measured as the sum of both sides, is an objectively measurable sign with very high reliability for detect vertebral vasculitis in patients with GCA. It is proposed here as a novel echographic sign, which can aid the detection of the involvement of an artery where the complications are especially serious.
Effects of gut microbiota on prostatic cancer: a two-sample Mendelian randomization study
Authors: Xie Qingpeng , Hu Bin 
Published: November 2023

AimRecent observational and small-sample case-control studies have shown a relationship between gut microbiota composition and prostatic cancer (PCa). Nevertheless, the causal association between gut microbiota and PCa is still unclear. Herein, we used the Mendelian randomization (MR) method to explore the potential causal relationship between gut microbiota and PCa.MethodsIn this two-sample MR study, data were extracted from the summary statistics of gut microbiota from the largest available genome-wide association study meta-analysis conducted by the MiBioGen consortium (n = 14,306) and the Dutch Microbiome Project (n = 8,208). Summary statistics for PCa were obtained from the FinnGen consortium release data (n = 95,213). Inverse variance weighted (IVW), MR-Egger, strength test (F), and MR-PRESSO were used to examine the potential causal association between gut microbiota and PCa. Cochran's Q statistics were used to quantify the heterogeneity of instrumental variables.ResultsIVW estimates suggested that the relative abundance of Akkermansia muciniphila (odds ratio [OR] = 0.7926, 95% confidence interval [CI]: 0.6655–0.9440) and Bacteroides salyersiae (OR = 0.9023, 95% CI: 0.8262–0.9853) were negatively associated with the odds of PCa, while that of Eubacterium biforme (OR = 1.1629, 95% CI: 1.0110–1.3376) was positively associated with the odds of PCa. In addition, we explored these relationships among patients without other cancers and similarly found that the relative abundance of Akkermansia muciniphila, Bacteroides salyersiae, and Eubacterium biforme were linked to PCa (all P &lt; 0.05).ConclusionGut microbiota potentially influenced the occurrence of PCa. Our findings may provide some new ideas for researching the methods of PCa prevention. In addition, further studies are needed to explore the causal association and specific underlying mechanisms between gut microbiota and PCa.
Periaqueductal/periventricular gray deep brain stimulation for the treatment of neuropathic facial pain
Authors: Mandat Victor , Zdunek Pawel R. , Krolicki Bartosz , Szalecki Krzysztof , Koziara Henryk M. , Ciecierski Konrad , Mandat Tomasz S. 
Published: November 2023

BackgroundThe Periaqueductal gray (PAG) and the periventricular gray (PVG) are the anatomical targets for deep brain stimulation (DBS) to treat severe, refractory neuropathic pain.MethodsSeven (four female and three male) patients were qualified for PAG/PVG DBS because of neuropathic facial pain. Frame-based unilateral implantations of DBS were conducted according to indirect planning of the PAG/PVG, contralateral to reported pain (3389, Activa SC 37603, Medtronic). The efficacy of PAG/PVG DBS on pain was measured with Numeric Pain Rating Scale (NRS) and Neuropathic Pain Symptom Inventory (NPSI) before surgery and 3, 12, and 24 months after surgery.ResultsThe mean age of the group at the implantation was 43.7 years (range: 28–62; SD: 12.13). The mean duration of pain varied from 2 to 12 years (mean: 7.3; SD: 4.11). Five patients suffered from left-sided facial pain and two suffered right-sided facial pain. The etiology of pain among four patients was connected to ischemic brain stroke and in one patient to cerebral hemorrhagic stroke. Patients did not suffer from any other chronic medical condition The beginnings of ailments among two patients were related to craniofacial injury. NRS decreased by 54% at the 3 months follow-up. The efficacy of the treatment measured with mean NRS decreased at one-year follow-up to 48% and to 45% at 24 months follow-up. The efficacy of the treatment measured with NPSI decreased from 0.27 to 0.17 at 2 years follow-up (mean reduction by 38%). The most significant improvement was recorded in the first section of NPSI (Q1: burning- reduced by 53%). The records of the last section (number five) of the NPSI (paresthesia/dysesthesia- Q11/Q12) have shown aggravation of those symptoms by 10% at the two-years follow-up. No surgery- or hardware-related complications were reported in the group. Transient adverse effects related to the stimulation were eliminated during the programming sessions.ConclusionPAG/PVG DBS is an effective and safe method of treatment of medically refractory neuropathic facial pain. The effectiveness of the treatment tends to decrease at 2 years follow-up. The clinical symptoms which tend to respond the best is burning pain. Symptoms like paresthesia and dysesthesia might increase after DBS treatment, even without active stimulation.
Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes
Authors: Lin Danna , Yang Keyan , Yu Lihua , Huang Lulu , Lai Xiaorong , Wu Li , Xia Xiayu , Zhang Jingwen , Zheng Qinlong , Yang Lihua 
Published: November 2023

BackgroundOverexpression of the cytokine receptor-like factor 2 (CRLF2) gene is the most common feature in the Philadelphia chromosome (Ph)-like subtype of B-cell acute lymphoblastic leukemia (B-ALL). However, the predictive value of CRLF2 overexpression for the prognosis of pediatric B-ALL patients remain controversial. The molecular mechanisms that upregulate CRLF2 expression level in patients has not been fully elucidated.MethodsIn this study, the prognostic impact of CRLF2 expression level on molecular types of B-ALL in pediatric patients from Zhujiang Hospital (n = 111) was retrospectively analyzed. Youden index analysis was used to categorize CRLF2 expression into 3 groups, and these categories more precisely described the differences in the prognosis of patients with varying expression levels of CRLF2 in both the Zhujiang Hospital cohort and the TARGET cohort.ResultsWe used the Zhujiang Hospital cohort as a discovery cohort to determine the cutoff value of CRLF2 expression. CRLF2-high patients accounted for approximately 6%. In addition, the percentage of bone marrow blast cells and initial white blood cell count in CRLF2-high patients were higher than those in CRLF2-low patients, and MRD turned negative slower. The results were validated in the TARGET cohort and indicated that CRLF2 overexpression could be subdivided by CRLF2 expression levels into 2 categories: CRLF2-high with a poor survival and CRLF2-medium with a good OS and EFS. Such heterogeneity was attributed to the different molecular mechanisms leading to CLRF2 upregulation, where the CRLF2 overexpression level was high in Ph-like B-ALL and medium in high hyperdiploid B-ALL.ConclusionThis study highlights the importance of the molecular mechanisms of the upregulation of CRLF2 expression in predicting the prognosis of pediatric B-ALL patients.
Low-quality of patient-reported outcome reporting in randomized clinical trials of major depressive disorder—a meta-epidemiological review
Authors: Zhou Jia , Qi Han , Hu Jia , Feng Zizhao , Wang Gang 
Published: November 2023

ObjectiveOur goal was to review current peer-reviewed articles in which the BDI (Beck Depression Inventory), PHQ-9 (Patient Health Questionnaire), or QIDS-SR16 (16-Item Quick Inventory of Depressive Symptomatology) was used as the primary or secondary outcome measure and to evaluate the quality of PRO (Patient-Reported Outcome) reporting in RCTs (Randomized Controlled Trials) according to the 2013 PRO-specific CONSORT (Consolidated Standards of Reporting Trials) extension.MethodsWe systematically searched in electronic databases. A study would be included if it included patients diagnosed with major depressive disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM) or International Classification of Diseases, version 10 (ICD-10) as participants, was a randomized controlled trial, included the BDI, PHQ-9, or QIDS-SR16 as the primary or secondary outcome measure, published between 1990 and 2013, and was in English. Two of the authors evaluated the quality of PRO reporting according to the 2013 CONSORT-PRO. Logistic regression were used to evaluate the association between reporting completeness and trial characteristics.ResultsA total of 116 studies were included. These studies were conducted in 25 countries. Sample sizes ranged from 12 to 750. The CONSORT-PRO was not cited in any one of the included studies. Among the 116 studies, 2 (1.72%) studies introduced the rationale for PRO assessment, 60 (51.72%) studies explicitly stated statistical approaches for dealing with missing data, 87 (75.00%) studies reported PRO outcome data at baseline and at subsequent time points. The mean score of reporting completeness was 66.24%. Significantly higher reporting completeness was found for RCTs published after 2013 (OR, 95%CI: 3.81, 1.32–10.99). Studies with a higher sample size were more completely reported than studies with a lower sample size (OR, 95%CI: 1.01, 1.00–1.02).ConclusionThe CONSORT-PRO guidance was rarely cited. The quality of PRO reporting in depression studies requires improvement. This result may be meaningful for the promotion of PRO reporting in RCTs.
Functions of nonsuicidal self-injurious behavior in Russian patients with suicidal ideation
Authors: Zinchuk Mikhail , Kustov Georgii , Popova Sofya , Mishin Ilya , Voinova Nadezhda , Gersamija Anna , Yakovlev Alexander , Guekht Alla 
Published: November 2023

IntroductionNonsuicidal self-injurious behavior (NSSI) is an important risk factor for future suicide attempts. Previous research has identified a number of motivations for engaging in NSSI. The aim of the present study was to translate the Inventory of Statements About Self-Injury (ISAS) into Russian and then to evaluate its psychometric properties in a sample of patients with non-psychotic mental disorders and suicidal ideation (SI). Other aims were to determine the prevalence of specific NSSI functions in this population and to assess the relationship between different NSSI functions and clinical and psychological parameters.Participants and methodsThe study was conducted at the largest center for non-psychotic mental disorders in Moscow. All admitted patients with both NSSI and SI completed the Russian version of the ISAS-II, underwent the Self-Injurious Thoughts and Behaviors Interview, and completed the Personality Inventory for DSM-5 and ICD-11 Brief Form Plus-Modified, the Beck Depression Inventory, and the State–Trait Anxiety Inventory.ResultsA total of 614 patients were included in the study. 543 (88.4%) patients were assigned female at birth with a mean age of 24.86 (7.86) years. Factor analysis supported a two-factor structure (Intrapersonal and Interpersonal) of the Russian version of the ISAS-II, but in contrast to the original study, the “Marking distress” function loaded more strongly on the Interpersonal factor. In people with non-psychotic mental disorders and SI, Interpersonal functions of NSSI are associated with more severe depressive symptoms (r = 0.34), 12 months history of NSSI (r = 0.30), higher number of NSSI methods (r = 0.41), likelihood of future NSSI (r = 0.35) and psychoticism (r = 0.32).ConclusionThe Russian version of the ISAS-II is a valid and reliable instrument for assessing NSSI functions in a population at high risk for suicide attempts. Interpersonal functions are associated with a number of unpleasant clinical and psychological features.
Degassing Dissolved Oxygen through Bubbling: The Contribution and Control of Vapor Bubbles
Authors: Jun Yong-Du 
Published: November 2023

An innovative yet sustainable approach for industrial deaeration is proposed, with demonstrated results and analyses, to contribute to finding solutions to improve energy efficiency in this field. Vacuum bubbling deaeration, sharing the same working principles of solubility control and the mass diffusion through vapor (or steam) with conventional thermal deaeration processes, works, however, at lower vacuum pressures. It neither resorts to heating nor requires any third-party materials such as membranes or gases, achieving orders of magnitude of reduction in the expected energy consumption in a simple and concrete way. In this study, the mechanisms of vapor bubble generation and retention were discussed by employing a vacuum bubbling model based on the experimental apparatus at Kongju National University, which uses a venturi-nozzle bubbler. The four parameters influencing vapor bubble generation and retention were identified as vessel pressure p1, nozzle depth Δh, nozzle performance p4−p3, and water temperature Tw. A series of deaeration experiments using the present approach for a tap water sample of 360~400 L were conducted under four different conditions to investigate the effects of the water temperature, vessel pressure, and bubbler nozzle depth. Final dissolved oxygen (DO) concentrations close to zero could be achieved with a vessel pressure of p1=1 kPa, with different bubbling times to reach a zero mg/L reading of DO concentration (case 2 and 3), which demonstrates the vital roles of the vapor bubble generation condition of (psat−p3) and retention condition of (p4−psat) in achieving the lowest DO concentration. Analysis of the test results, based on the discrete-bubble model with the measured DO concentrations and degassing rates, showed promising results in reproducing the experimental data. Though the potential of vacuum bubbling deaeration is demonstrated, for the first time, to its full extent, further research efforts are encouraged in many areas, including more case-specific validation test cases with optimum operating conditions along with the study of more detailed modeling for performance prediction, including energy analysis.
Prospective analysis of the impact of Chronic Kidney Disease on patients and caregivers
Authors: Pereira Beatriz dos Santos , Kirchmaier Filomena Maria , Fernandes Neimar da Silva , Suassuna Lucas Fernandes , Fernandes Natalia Maria da Silva 
Published: November 2023

Introduction. Chronic kidney disease (CKD) has a high incidence, prevalence and morbidity and mortality among the world population, negatively impacting the biopsychosocial aspects of patients and family caregivers. Objective. To evaluate the association between the mental health of caregivers and CKD patients on dialysis. Method. A prospective cohort study, the sample included patients with CKD on dialysis at the University Hospital of the Federal University of Juiz de Fora (UFJF) and their family caregivers from 2015 to 2019. The instruments used for data collection were a sociodemographic questionnaire, the Perceived Social Support Scale (EPSS), the Hospital Anxiety and Depression Scale (HADS), the Lipp Stress Symptom Inventory (LISS), the SF-36 Quality of Life Questionnaire (SF-36), the Fatigue Pictogram. Results. Most patients were on haemodialysis for more than 4 years and were female, middle-aged, and black. Most caregivers were female, middle-aged and white. The participants in both groups predominantly married people with low levels of education. The general levels of mental health and quality of life (QoL) between patients and caregivers were similar. Conclusion. The mental health of patients and their family caregivers was similarly and negatively affected by CKD; therefore, treatment and interdisciplinary mental health care measures are urgent for this population.