bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant Melanoma of the Maxillary Gingiva: A Case Report
Authors: Perrotti Vittoria , Piattelli Adriano , Rubini Corrado , Fioroni Massimiliano , Petrone Giovanna 
Published: February 2005

Background: Mucosal malignant melanoma of the of the head and neck is a rare neoplasm, accounting for about 0.2% of all melanomas. We present the clinopathological findings of a case.Methods: An 83‐year‐old woman presented with a dark reddish pigmented lesion which had appeared 3 years previously.Results: Clinical examination revealed a sessile lesion, 1.5 cm in diameter, located on the vestibular maxillary gingiva next to the first molar area. Microscopic analysis of the neoplasm showed epithelioid cells with prominent nucleoli aggregated in solid nests. Cytoplasmic melanin pigmentation was present. The neoplastic cells were positive for HMB‐45 and S100 protein. The final histologic diagnosis was primary malignant melanoma of the gingiva. Physical examination and a computerized tomography scan of the neck, liver, and lungs ruled out the possibility of occult melanoma lesions elsewhere in the body.Conclusion: The prognosis for patients with oral malignant melanoma is extremely poor. Earlier recognition of this condition simplifies treatment and greatly improves the prognosis for these patients. J Periodontol 2004;75:1724‐1727.
A functional glutathioneS‐transferase P1 gene polymorphism is associated with methamphetamine‐induced psychosis in Japanese population
Authors: Hashimoto Tasuku , Hashimoto Kenji , Matsuzawa Daisuke , Shimizu Eiji , Sekine Yoshimoto , Inada Toshiya , Ozaki Norio , Iwata Nakao , Harano Mutsuo , Komiyama Tokutaro , Yamada Mitsuhiko , Sora Ichiro , Ujike Hiroshi , Iyo Masaomi 
Published: February 2005

AbstractSeveral lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathioneS‐transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism ofGSTP1gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping forGSTP1gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP). Association betweenGSTP1gene polymorphism and clinical features (prognosis of psychosis (transient‐type and prolonged‐type), spontaneous relapse (positive and negative), and poly‐substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06–2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13–2.97) between MAP abusers with psychosis (transient‐type and prolonged‐type) and controls was detected. Our findings suggest that the polymorphism (Ile105Val) on exon 5 of theGSTP1gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population. © 2005 Wiley‐Liss, Inc.
Accelerated electron effects on EVA based compound
Authors: Budrugeac P. , Zaharescu T. , Marcuta M. , Marin Gh. 
Published: February 2005

AbstractThe major effects induced by accelerated electron irradiation on EVA based polymeric compound were evaluated for various doses up to 240 kGy. Some main characteristics (gel fraction, density, elongation at break, and tensile strength) were investigated. Oxygen uptake and thermal analysis methods (TG, DTG, and DTA) were applied for determination of oxidation resistance of radiation processed EVA samples. It was established that a 30 kGy exposure dose promotes maximum crosslinking. At this dose the density and tensile strength reach maximum values, which are maintained for higher doses up to 240 kGy. On the other hand, the thermooxidative stability exhibits a sharp decrease as the absorbed dose rises from 0 to 30 kGy and has a constant value for the absorbed dose range 30–240 kGy. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 613–617, 2005
Chemical polymerization of pyrrole in the presence of ketone–formaldehyde resins
Authors: Kızılcan Nilgün , Ustamehmetoğlu Belkıs 
Published: February 2005

AbstractThe chemical polymerizations of pyrrole in the presence of acetophenone and formaldehyde, cyclohexanone, acetaldehyde, and formaldehyde, cyclohexanone and formaldehyde, cyclohexanone, resorcinol, and formaldehyde, cyclohexanone and lignosulfonate formaldehyde, and cyclohexanone, pyrrole, and formaldehyde were accomplished with Ce(IV) salt in acetonitrile solutions. The roles of the resin type, the addition order of the reactants, and the concentrations of the pyrrole and resin on the solubility and conductivity of the resulting products were investigated. The cyclohexanone–acetaldehyde–formaldehyde resin/polypyrrole copolymer had the highest solubility in dimethylformamide. The conductivity and solubility of the copolymers could be controlled by the Ce(IV)/pyrrole/resin molar ratio. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 618–624, 2005
Solubility of ethylene in toluene and toluene/styrene–butadiene rubber solutions
Authors: Wu Jialong , Pan Qinmin , Rempel Garry L. 
Published: February 2005

AbstractThe solubility of ethylene in toluene and in toluene (90 wt %)/styrene–butadiene rubber (SBR; 10 wt %) solutions was determined because the solubility data were of interest for the kinetic study of the metallocene‐catalyzed homopolymerization of ethylene and the copolymerization of ethylene with α‐olefins. The data were obtained over the temperature range of 293–343 K and the pressure range of 50–180 psi. An original Universal Functional Group Activity Coefficient (UNIFAC) model was applied for the ethylene–toluene system, and a UNIFAC‐ZM model (a modified UNIFAC model proposed by Zhong and Masuoka et al.) was applied for the ethylene–toluene/SBR ternary system. Henry's law was also used to correlate the experimental results of the two systems. A comparison was made between the UNIFAC models and Henry's law. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 645–649, 2005
Heterogeneous polyamide 66/syndiotactic polystyrene blends: Phase structure and thermal and mechanical properties
Authors: Kolařík J. , Fambri L. , Šlouf M. , Konečný D. 
Published: February 2005

AbstractThe structural and physical properties of polyamide 66 (PA66)/syndiotactic polystyrene (sPS) blends were studied with electron microscopy, wide‐angle X‐ray scattering (WAXS), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis, and tensile creep, stress–strain, and impact measurements. Attention was primarily concentrated on blends with sPS weight fractions (w2) in the range of 0 < w2 ≤ 0.50. DSC and WAXS showed that the integral crystallinity of the PA66 and sPS components in the blends was virtually unaffected by the blend composition. Polymorphism of sPS was observed for blends with w2 ≥ 0.50. Blends with 0.40 ≤ w2 ≤ 0.60 consisted of partially cocontinuous components; otherwise, particles of the minority component were dispersed in the continuous majority component. The compatibilizer enhanced interfacial adhesion so that no debonding of the components in the fractured blends was observed. The compliance and creep rate of the blends at room temperature decreased proportionally to the sPS fraction; a corresponding increase in the storage modulus (E′) was observed in the 25–100°C interval. However, E′ (125°C) noticeably declined with w2 and thus showed that sPS did not improve the dimensional stability of the blends at elevated temperatures. The yield strength consistently grew with w2, whereas the yield strain dropped markedly; blends with w2 ≥ 0.60 were brittle, showing very low values of the ultimate properties. The stress at break, strain at break, and tensile energy to break displayed some local maxima at 0.25 ≤ w2 ≤ 0.30, whereas the tensile impact strength steeply decreased. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 673–684, 2005
Rheological properties of polystyrene blends with rigid ladderlike polyphenylsilsesquioxane
Authors: Li Gui Zhi , Matsuda T. , Nishioka A. , Miyata K. , Masubuchi Y. , Koyama K. , Pittman C. U. 
Published: February 2005

AbstractPolystyrene (PS) blends with rigid ladderlike polyphenylsilsesquioxane (PPSQ) were prepared by solution casting followed by hot pressing. The rheological properties of these blends were studied under dynamic shear and uniaxial elongation conditions. The loss modulus (G″) and dynamic shear viscosity (η*) of the 95/5 PP/PPSQ blend were slightly lower than those of pure PS at low frequencies (≤10−2 rad/s). However, the storage modulus (G′), G″, and η* of the other blends (90/10, 85/15, and 80/20) were higher than those of pure PS and increased with PPSQ content. The ηE data demonstrated that PS/PPSQ blends exhibited slightly weaker (5% PPSQ) or much weaker (10% PPSQ) strain hardening than PS. In contrast, the 85/15 and 80/20 PP/PPSQ blends showed strain softening, and the extent of strain softening increased with PPSQ content. PS entanglements might have been reduced by the specific interactions between PS and PPSQ, which locally ordered some PS molecules in the 95/5 blend sample, because most of the PPSQ might have been well dispersed in the PS continuous phase, and only a few small PPSQ particles (∼1.3 μm) were formed because of good miscibility. However, at high PPSQ contents (≥10%), many larger hard PPSQ particles were formed, which acted as fillers during the rheological measurements. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 706–713, 2005
Lower and central tumor location correlates with lymphoscintigraphy drainage to the internal mammary lymph nodes in breast carcinoma
Authors: Shahar Karen H. , Buchholz Thomas A. , Delpassand Ebrahim , Sahin Aysegul A. , Ross Merrick I. , Ames Fredrick C. , Kuerer Henry M. , Feig Barry W. , Meric‐Bernstam Funda , Babiera Gildy V. , Singletary S. Eva , Akins Jeri S. , Mirza Nadeem Q. , Hunt Kelly K. 
Published: February 2005

AbstractBACKGROUNDRadiation to the internal mammary chain (IMC) may be indicated for breast carcinoma patients with positive axillary sentinel lymph nodes (SLNs) and lymphoscintigraphic evidence of drainage to the IMC. The purpose of this study was to identify predictors of IMC drainage in patients with positive axillary SLNs.METHODSThe records of 297 breast carcinoma patients with positive axillary SLNs and preoperative lymphoscintigraphy were reviewed between 1995 and 2002. Radiolabeled colloid was injected peritumorally with lymphoscintigraphy performed 30–60 minutes later. Drainage to the regional nodes of 279 patients was seen on lymphoscintigraphy. Associations among patient and tumor‐related factors and drainage to the IMC were examined.RESULTSDrainage to the IMC on lymphoscintigraphy was seen in 63 patients (21%). IMC drainage only occurred in 4 patients, and 59 patients had both axillary and IMC drainage. The only variable that correlated with IMC drainage was tumor location (P = 0.017). Rates of drainage to the IMC were 14.1% for upper outer quadrant (n = 128), 16.7% for upper inner quadrant (n = 30), 31.6% for lower outer quadrant (n = 19), 42.9% for lower inner quadrant (n = 14), and 28.4% for central tumors (n = 88). IMC drainage rates differed significantly between upper and lower tumors (lower 36.4% vs. central 28.4% vs. upper 14.6%, P = 0.003) but not between medial and lateral tumors (medial 25.0% vs. central 28.4% vs. lateral 16.3%, P = 0.077).CONCLUSIONSPatients with tumors in the lower or central breast and positive axillary SLNs have increased incidence of drainage to the IMC. Preoperative lymphoscintigraphy can help to define the nodal basins at risk for harboring disease. Cancer 2005. © 2005 American Cancer Society.
Interobserver agreement in the interpretation of anal intraepithelial neoplasia
Authors: Lytwyn Alice , Salit Irving E. , Raboud Janet , Chapman William , Darragh Teresa , Winkler Barbara , Tinmouth Jill , Mahony James B. , Sano Marie 
Published: February 2005

AbstractBACKGROUNDAnal carcinoma incidence is increasing, and is highest among men with human immunodeficiency virus (HIV) infection who have sex with men. Anal carcinoma and anal intraepithelial neoplasia (AIN) are ascertained on tissue histology, but requires invasive procedures. Screening for AIN using anal cytology was suggested. The authors evaluated agreement on cytologic and biopsy specimens from HIV‐positive men undergoing anal carcinoma screening.METHODSOne hundred twenty‐nine HIV‐positive men with a history of anal‐receptive intercourse underwent anal cytology, anoscopy, and biopsy. Four pathologists independently assessed cytology and biopsy specimens and reached consensus for discordant cases.RESULTSEach pathologist evaluated 120 cytology and 155 biopsy specimens. The weighted kappa value for overall agreement was 0.54 (95% confidence interval [CI], 0.49–0.59) for cytology specimens and 0.59 (95%CI, 0.55–0.63) for biopsy specimens. The median kappa values for pairwise agreement among pathologists and for agreement with consensus were, respectively, 0.69 and 0.77 for cytology and 0.66 and 0.75 for biopsy. At least 3 pathologists were in agreement for 92 (76.7%) cytology and 134 (86.5%) biopsy specimens. Reliability for the Bethesda classification system was at least moderate, except for the cytologic category of atypical squamous cells of undetermined significance (kappa = 0.12). Fourteen of 29 (48.3%) cytology specimens and 36 of 47 (76.6%) biopsy specimens with consensus interpretation of high‐grade squamous intraepithelial lesions (HSIL) were interpreted originally as HSIL by ≥ 3 pathologists. The kappa value for agreement with consensus distinguishing HSIL from non‐HSIL ranged from 0.55 to 0.88 for cytology specimens and from 0.76 to 0.94 for biopsy specimens.CONCLUSIONSAgreement for cytologic and biopsy interpretations was generally at least moderate. Nevertheless, these results supported the need for disease indicators with greater reliabililty. Cancer 2005. © 2005 American Cancer Society.
Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach
Authors: Kim Min A , Lee Hye Seung , Yang Han‐Kwang , Kim Woo Ho 
Published: February 2005

AbstractBACKGROUNDAlthough the incidence of adenocarcinoma of the stomach has decreased over the past several decades, gastric cardia carcinoma has increased over the same period.METHODSThe clinicopathologic characteristics and immunohistochemical staining results of 21 proteins were investigated in 165 patients with cardia carcinoma, including 74 patients with true cardia carcinoma and 91 patients with subcardia carcinoma, and the results were compared with the results from 564 patients with noncardia carcinoma.RESULTSIn the clinicopathologic analysis, patients who had cardia carcinoma tended to have tumors with poorly differentiated histology according to the World Health Organization classification system (P = 0.012), diffuse type according to the Lauren classification system (P = 0.049), and advanced pathologic TNM stage (P < 0.001). On immunohistochemical staining, loss of the p16 (P = 0.038) and smad4 (P < 0.001) tumor suppressor genes was more frequent in cardia carcinoma than in noncardia carcinoma. Carcinoembryonic antigen and CD44 overexpression were more frequent in patients with cardia carcinoma (P < 0.05). Conversely, patients who had cardia carcinoma exhibited less frequent expression of MUC1 (P = 0.008) and MUC5AC (P = 0.006) compared with patients who had noncardia carcinoma. Epstein–Barr virus infection was more common in patients with cardia carcinoma (P < 0.001). In the survival analysis, the patients with cardia carcinoma had a poorer prognosis. In the multivariate analysis, tumor location in the cardia was confirmed as an independent, poor prognostic factor in patients with gastric carcinoma.CONCLUSIONCardia carcinoma and noncardia carcinoma differed in their clinicopathologic characteristics and in their alterations of gene expression, as evaluated by immunohistochemistry. The current results support the hypothesis that cardia carcinoma forms a specific category of gastric carcinoma that is distinct from noncardia carcinoma. Cancer 2005. © 2005 American Cancer Society.
JavaSymphony: a new programming paradigm to control and synchronize locality, parallelism and load balancing for parallel and distributed computing
Authors: Fahringer Thomas , Jugravu Alexandru 
Published: February 2005

AbstractThere has been an increasing research interest in extending the use of Java towards performance‐oriented programming for distributed and concurrent applications. JavaSymphony is a Java‐based programming paradigm that allows the programmer to control parallelism, load balancing, and locality at a high level of abstraction. Objects can be explicitly distributed and migrated based on a high‐level API to static/dynamic system parameters and dynamic virtual distributed architectures, which impose a virtual hierarchy on a distributed system of physical computing nodes. In this paper we describe various extensions to the original JavaSymphony API, which includes a generalization of virtual architectures that can be used to specify and to request arbitrary heterogeneous distributed and concurrent architectures inside of a JavaSymphony program. The number of threads that execute an object's methods can be controlled dynamically through single‐ and multi‐threaded objects. Conventional Java objects can be dynamically converted to JavaSymphony objects. A (un)lock mechanism has been introduced in order to avoid inconsistent modifications of objects or virtual architectures. A sophisticated event mechanism for asynchronous communication, coordination, and interaction is provided. Several synchronization constructs including distributed barrier synchronization and synchronization for asynchronous method invocations have been included. Several experiments are presented to demonstrate the effectiveness and efficiency of JavaSymphony. Copyright © 2005 John Wiley & Sons, Ltd.
Object‐oriented programming in peer‐to‐peer systems
Authors: Eugster Patrick Th. , Baehni Sebastien 
Published: February 2005

AbstractLeveraged by the success of applications aiming at the ‘free’ sharing of data in the Internet, the paradigm of peer‐to‐peer (P2P) computing has had substantial consideration devoted to it recently. This paper presents a high‐level abstraction for remote object interaction in a P2P environment, called borrow/lend (BL). We present the principles underlying our BL abstraction, and illustrate how this abstraction can be used to program P2P applications in Java. We contrast our abstraction with established abstractions for distributed programming such as the remote method invocation or the tuple space, illustrating how the BL abstraction, obviously influenced by such previous abstractions, unifies flavors of these, but also how it captures the constraints specific to P2P environments. Copyright © 2005 John Wiley & Sons, Ltd.
A method‐level comparison of the Java Grande and SPEC JVM98 benchmark suites
Authors: Gregg David , Power James , Waldron John 
Published: February 2005

AbstractIn this paper we seek to provide a foundation for the study of the level of use of object‐oriented techniques in Java programs in general, and scientific applications in particular. Specifically, we investigate the profiles of Java programs from a number of perspectives, including the use of class library methods, the size of methods called, the mode of invoke instruction used and the polymorphicity of call sites. We also present a categorization of the nature of small methods used in Java programs. We compare the Java Grande and SPEC JVM98 benchmark suites, and note a significant difference in the nature and composition of these suites, with the programs from the Java Grande suite demonstrating a less object‐oriented approach. Copyright © 2005 John Wiley & Sons, Ltd.
Implementation and performance of a particle‐in‐cell code written in Java
Authors: Markidis S. , Lapenta G. , VanderHeyden W. B. , Budimlić Z. 
Published: February 2005

AbstractPlasma simulation is an important example of a high‐performance computing application where computer science issues are of great relevance. In a plasma, each particle, electron or ion, interacts with the external fields and with other particles in ways that can be readily and effectively emulated using object‐oriented programming. However, the great cost of plasma simulations has traditionally discouraged object‐oriented implementations due to their perceived inferior performance compared with classic procedural FORTRAN or C. In the present paper, we revisit this issue. We have developed a Java particle‐in‐cell code for plasma simulation, called Parsek. The paper considers different choices for the object orientation and tests their performance. We find that coarse‐grained object orientation is faster and practically immune from any degradation compared with a standard procedural implementation (with static classes). The loss in performance for a fine‐grained object orientation is a factor of about 50%, which can be almost completely eliminated using advanced Java compilation techniques. The Java code Parsek also provides an interesting realistic application of high‐performance computing to compare the performance of Java with FORTRAN. We have conducted a series of tests considering various Java implementations and various FORTRAN implementations. We have also considered different computer architectures and different Java Virtual Machines and FORTRAN compilers. The conclusion is that with Parsek, object‐oriented Java can reach CPU speed performances more or less comparable with procedural FORTRAN. This conclusion is remarkable and it is in agreement with the most recent benchmarks, but is at variance with widely held misconceptions about the alleged slowness of Java. Copyright © 2005 John Wiley & Sons, Ltd.
Towards enabling peer‐to‐peer Grids
Authors: Fox Geoffrey , Pallickara Shrideep , Rao Xi 
Published: February 2005

AbstractIn this paper we propose a peer‐to‐peer (P2P) Grid comprising resources such as relatively static clients, high‐end resources and a dynamic collection of multiple P2P subsystems. We investigate the architecture of the messaging and event service that will support such a hybrid environment. We designed a distributed publish–subscribe system NaradaBrokering for XML‐specified messages. NaradaBrokering provides support for centralized, distributed and P2P (via JXTA) interactions. Here we investigate and present our strategy for the integration of JXTA into NaradaBrokering. The resultant system naturally scales with multiple Peer Groups linked by NaradaBrokering. Copyright © 2005 John Wiley & Sons, Ltd.