bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Possibilities of Observational Research in Workplace Learning: The Case of Video‐Reflexive Ethnography
Authors: Noble Christy , Billett Stephen , Furness Linda , Carrigan Brendan , O’Shannessy Megan , Teodorczuk Andrew , Ajjawi Rola 
Published: January 2025

ABSTRACTObjectiveThis paper, using video‐reflexive ethnography (VRE) as a case study, explores the prospects for and possibilities of observational research in workplace learning.MethodsFocusing on VRE methodology and drawing on its principles of care, collaboration, exnovation (paying attention to existing strengths) and reflexivity, we elaborate the prospects for and scope of possibilities for observational research.ResultsVRE's flexibility and participatory nature enable researchers and participants to understand the complexities of learning in situ and the dynamic interactions between learning and work practice. We emphasise the importance of considering participants' (e.g., clinicians) lived experiences and recommend prioritising their engagement, reflexivity and knowledge co‐creation in observational research to inform processes of learning through work practice. This participatory approach enables capturing and articulating diverse perspectives on these learning processes and, importantly, embraces the diverse perspectives of participants and researchers informing this situational approach to learning.ConclusionThe case study of VRE illustrates the potential and prospects of observational approaches in improving our understanding and facilitation of learning through practice in health professions education, highlighting its flexibility and innovation. By foregrounding participants' perspectives and fostering a collaborative research environment, VRE offers fresh insights into the complexities of learning in clinical settings. This research contributes to the broader discourse on educational methodologies, suggesting that VRE can significantly advance research in workplace learning.
BIM‐Based Indoor Navigation Using End‐to‐End Visual Localization and ARCore
Authors: Tang Shengjun , Wan Jiawei , Li Yusong , Huang Hongsheng , Wang Weixi , Guo Renzhong , Zhang Yunjie 
Published: January 2025

ABSTRACTTraditional localization methods based on sensors such as Bluetooth and Wi‐Fi struggle to achieve the required accuracy for fine‐grained applications like AR navigation or robot localization. Accurate global position estimation and seamless AR navigation in dynamic indoor environments can significantly enhance the intelligence of indoor scene applications. This paper proposes an as‐built BIM‐based indoor navigation using End‐to‐End visual localization and ARCore. First, based on pre‐captured RGB image sequences, a sparse point cloud of the indoor space can be constructed using Structure from Motion (SFM) methods, and the camera pose of each RGB image can be obtained. At the same time, image features are extracted in a multi‐scale manner using end‐to‐end deep learning, and an image database is constructed for later scene retrieval and matching. Second, Building Information Modeling (BIM) model is constructed for a specific indoor scene, and an automated reconstruction of the indoor navigation topology map is performed based on this model. Finally, by giving a query image, the optimal matching image in the image database is obtained through scene retrieval methods. And the camera pose of the query image is iteratively optimized by multiple feature maps. Then path planning is performed based on the indoor navigation topology map with ARCore. In order to assess the effectiveness of the proposed method, Experimental are conducted for the evaluation of the global positioning estimation module and AR navigation module using both public datasets and our own collected data. The experimental results demonstrate that in publicly accessible datasets, the global positioning error consistently remains within the 20‐cm range, with the majority of these datasets achieving a positioning error of 10 cm or less. Furthermore, the experimental results of AR navigation show that the method enables an approximate positioning accuracy of 10 centimeters in AR navigation within a length of 50 m.
Effects of patent foramen ovale in migraine: a metabolomics‐based study
Authors: Dong Bosi , Li Xin , Zhang Lu , Liang Ge , Zheng Wen , Gui Luolan , Ji Shuming , Tang Yusha , Li Hua , Li Wanling , Yang Ruiqi , Li Yajiao , Peng Anjiao , Chen Yucheng , Gong Meng , Chen Lei 
Published: January 2025

AbstractPatent foramen ovale (PFO), a cardiac anatomical anomaly inducing abnormal haemodynamics, leads to a paradoxical bypass of the pulmonary circulation. PFO closure might alleviate migraines; however, clinical evidence and basic experiments for the relationship are lacking. To explore the effect of PFO on migraine, 371 migraineurs finishing blood tests and contrast transthoracic echocardiography for the detection of PFO were prospectively included. Multivariate regression analysis revealed that PFO was independently associated with aura, and lower cystatin‐C (cys‐C) and calcium levels. Among them, patients with PFO who underwent percutaneous PFO closure were continuously followed up 1 year after the operation. The intensity of migraine was significantly relieved and the levels of cys‐C and calcium increased after PFO closure. Untargeted and targeted metabolomics of plasma from migraineurs before and after PFO closure revealed that 5‐HT and glutathione (GSH) metabolites were differentially expressed after PFO closure. The differential metabolites were then validated in the plasma and brain tissues of PFO mouse models by LC‐MS/MS analysis. Desorption electrospray ionization mass imaging demonstrated that these metabolic alterations occurred mainly in the posterior cerebral cortex. Collectively, aura, cys‐C and calcium could be biomarkers of migraineurs with PFO. PFO might have an impact on the posterior head associated with the regulation of 5‐HT and GSH. PFO closure might relieve migraine by improving 5‐HT clearance metabolism and ameliorating redox reactions. Our results may provide evidence for an indication of PFO closure in migraine and support the related potential mechanism.
imageKey points
Aura, and levels of cystatin‐C and calcium are biomarkers of migraineurs with a patent foramen ovale (PFO).
The clearance of pulmonary metabolism of 5‐HT and deoxygenated blood might be the reason for the improvement of migraine symptoms in patients with PFO.
The posterior region of the brain is the main area responsible for PFO‐induced migraine.
One Size Does Not Fit All: Pluralistic Practice for Long-Term Work With a Premiership Rugby Player
Authors: McKenzie Graham , Wagstaff Christopher R.D. 
Published: January 2025

In this article, we illustrate the service delivery with a 26-year-old, male, professional rugby union player, who over our two-and-a-half-year working relationship brought a multitude of different challenges to sessions. In the initial 6 months of the work presented in this case, the sport psychology practitioners (SPPs; both authors) codelivered sessions. We offer details of this codelivery period, as well as the role that the supervisor (second author) played in the latter 2 years of work. The SPPs worked from a pluralistic philosophy, which acknowledges that different clients need different things at different points in time. As such, we outline how the SPPs engaged in an ongoing process of metacommunication and shared decision making to establish the client’s goals and preferences and how this was renegotiated over time. We also depict the different approaches that the SPPs were required to take to meet the client’s needs, including referring to another practitioner when appropriate. We conclude by sharing several reflections on our service delivery and offer applied recommendations for SPPs who seek to use pluralistic approaches in their work.
Class IIa histone deacetylase (HDAC) inhibitor TMP269 suppresses lumpy skin disease virus replication by regulating host lysophosphatidic acid metabolism
Authors: Cheng Pengyuan , Wang Xiangwei , Wang Shasha , Ren Shanhui , Liang Zhengji , Guo Ke , Qu Min , Meng Xuelian , Dou Yongxi , Yin Xiangping , Sun Yuefeng 
Published: January 2025

ABSTRACT

Lumpy skin disease virus (LSDV) infection poses a significant threat to global cattle farming. Currently, effective therapeutic agents are lacking. TMP269, a small molecule inhibitor of class IIa histone deacetylase inhibitor, plays a vital role in cancer therapy. In this study, we demonstrated that TMP269 treatment inhibits the early-stage replication of LSDV in a dose-dependent manner. RNA sequencing data revealed that metabolism-related signaling pathways were significantly enriched after LSDV infection. Furthermore, untargeted metabolomics analysis revealed that lysophosphatidic acid (LPA), a key metabolite of the glycerophospholipid pathway, was upregulated following LSDV infection and downregulated after TMP269 treatment. In addition, exogenous LPA promotes LSDV replication by activating the mitogen-activated protein kinase (MEK)/extracellular-signal-regulated kinase (ERK) signaling pathway and suppressing the host’s innate immune response. Furthermore, treatment with the LPA receptor inhibitor Ki16425 suppressed LSDV replication and promoted the host’s innate immune response. These findings suggest that LSDV infection can induce LPA expression and aid viral activation of the MEK/ERK signaling pathway and escape of the host’s innate immune response, whereas TMP269 treatment can inhibit LPA production and limit its promotion of LSDV replication. These data identified the antiviral mechanism of TMP269 and a novel mechanism by which LSDV inhibits host innate immune responses, providing insights into the development of new preventive or therapeutic strategies targeting altered metabolic pathways.

IMPORTANCE
Lumpy skin disease virus (LSDV) poses a significant threat to global cattle farming. Owing to insufficient research on LSDV infection, pathogenesis, and immune escape mechanisms, prevention and control methods against LSDV infection are lacking. Here, we found that TMP269, a class IIa histone deacetylase inhibitor, significantly inhibited LSDV replication. We further demonstrated that TMP269 altered LSDV infection-induced host glycerophospholipid metabolism. In addition, TMP269 decreased the accumulation of lysophosphatidic acid (LPA), a key metabolite in glycerophospholipid metabolism, induced by LSDV infection, and exogenous LPA-promoted LSDV replication by activating the mitogen-activated protein kinase (MEK)/extracellular-signal-regulated kinase (ERK) signaling pathway and suppressing the host innate immune response. Our findings identified the antiviral mechanism of TMP269 and a novel mechanism by which LSDV manipulates host signaling pathways to promote its replication, offering insights into the development of novel antiviral agents against LSDV infection.
Supplemental Material: Tracing crustal recycling mechanisms using Mo isotopes in high-Mg andesites
Authors: Zeng Yunchuan , al. et 
Published: January 2025

<p>Item S1 (details of the analytical methods); Item S2 (comprehensive evaluation of the roles of fractional crystallization and assimilation); Item S3 (spread-sheet Tables S1–S4 presenting new data reported in this study alongside previously published geochemical data used in our figures); and Item S4 (Figs. S1–S3, and all references in the supplemental material). </p>
Perceived effectiveness and recommendations from a childbirth quality assurance and improvement programme in India’s private sector: a qualitative evaluation using the RE-AIM framework
Authors: Spigel Lauren , Pallipamula Suranjeen , Chabba Rajat , Jindal Shweta , Usmanova Gulnoza , Bobanski Lauren , Desai Meghna , Divakar Hema , Dutta Sukanya , Gupta Aarushi , Henrich Natalie , Kinjawadekar Sucheta , Kumar Priti , Kumari Priyanka , Mukharya Prerna , Nair Tapas Sadasivan , Pai Hrishikesh , Purandare Ameya , Semrau Katherine , Sridhar Pompy , Marx Delaney Megan , Kumar Somesh 
Published: January 2025

IntroductionPrevious studies have revealed inconsistent quality of care in India’s private sector, where nearly one in three facility births take place. Manyata is a quality assurance and improvement programme launched in 2016 by the Federation of Obstetrics and Gynaecological Societies of India (FOGSI) that provides training, mentorship and accreditation to private maternity facilities. We aimed to understand participants’ motivations for joining or not joining, the perceived value of Manyata and recommendations for sustainment and scale.MethodsWe aimed to sample 238 Manyata participants for semi-structured, in-depth interviews between February and July 2021. Participants included facility owners, nurses, FOGSI quality assessors, programme implementers and Manyata leaders. Data were coded and analysed using a deductive and inductive process. Codes were mapped to the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework, which we expanded to include scale.ResultsWe interviewed 185 programme participants. Maternity facility owners joined Manyata due to its affiliation with FOGSI, encouragement from peers and the desire to standardise care and train their staff. Barriers to joining included cost, unclear value and little motivation to improve practice. Participants most valued Manyata for improving staff competency, quality of care, standardised care processes and staff satisfaction. Participants felt that continuous training, mentorship and quality assurance would be necessary to maintain Manyata over time, and Manyata could and should be scaled across India and to other countries.ConclusionStrategies for engaging with the private sector should include building strategic partnerships and messaging a value proposition that emphasises training, standardised care processes and improved quality of care. A blended virtual and in-person model may be leveraged for ongoing training and quality assurance and to scale across contexts. Our evaluation of Manyata distills tangible lessons that policymakers, professional societies and public health practitioners can use to bridge the quality gap in their own private-sector maternity systems.
Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022
Authors: Okonkwo Rita , Okunoye Olumide , Oyedele Oyewole , Edun Martin , Ezenwelu Ugochi , Aminu-Alhaji Asmau , Jedy-Agba Elima , Kombu Aondoakura , Attah Timothy , Jumare Jibreel , Andrew Nifarta , Enwerem Kenneth , Osawe Sophia , Ejeh Victor , Udioh Michaela , Okah-Avae Okame , Obak Elonna , Akanbi Olusola Anuoluwapo , Okoli Mary , Iriemenam Nnaemeka C , Abimiku Alash’le , Okoye McPaul 
Published: January 2025

BackgroundKnowledge, attitude and practices (KAP) towards COVID-19 can directly impact healthcare workers’ (HCWs) services and efforts to contain the spread of the disease. This study assessed KAP towards COVID-19 among HCWs (laboratorians, doctors, nurses and pharmacists) in Nigeria from August to December 2022.MethodA facility-based cross-sectional study was conducted on 1341 HCWs (laboratorians, doctors, nurses and pharmacists) in 7 healthcare facilities across 3 states in Nigeria. HCWs were selected using a stratified random sampling technique. A structured questionnaire including sociodemographic and health information, and KAP sections was administered to participants. Using Bloom’s cut-off, percentages of correct responses to KAP questions were grouped as either satisfactory (≥80%) or unsatisfactory (<80%). Binary logistic regression was used to determine the association between HCWs’ cadre and satisfactory KAP.ResultsThe proportions of HCW with satisfactory KAP were 64.5%, 51.2% and 5.3%, respectively. Laboratorians had the lowest satisfactory KAP scores (59.4%, 45.9% and 2.0%). There was a weak linear relationship between knowledge and practice (r=0.1, p:0.03), knowledge and attitude (r=0.2, p<0.001), and attitude and practice scores (r=0.20, p<0.001). 6–10 years of practice increased HCWs’ odds of satisfactory knowledge (p=0.049). HCWs’ cadre was not significantly associated with knowledge and practice towards COVID-19 (P>.05). However, nurses compared to laboratorians had higher odds of satisfactory attitude (p:0.033). Socio-demographic factors associated with satisfactory attitude towards COVID-19 were age group, gender, marital status, vaccination status, and satisfactory knowledge (p<.05). Satisfactory attitude and marital status were associated with satisfactory practice (p<.05).ConclusionThere are gaps in the practice of COVID-19 prevention among HCWs in Nigeria. Additional exploration is needed to understand the challenges of implementing safety protocols across cadres, particularly among laboratorians, to better handle future health emergencies. This study highlights the implementation strategies that include education and training, provision of personal protective equipment and clear guidelines for implementation of infection prevention and control practices.
Perceptions and reflections of embryo donation recipients: a qualitative follow-up study
Authors: Salari Salomeh , El-Gayar Mona , Lee Seungho , Mangels Joshua , Flyckt Rebecca , Madeira Jody , Klock Susan , Lindheim Steven R 
Published: January 2025

AbstractObjectiveCross-sectional quantitative data from donor embryo recipients suggest children conceived through embryo donation are psychosocially well adjusted with healthy parent–child relationships. This study delves deeper into this topic using a qualitative grounded theory approach to capture recipients’ experiences and perceptions regarding family-building through embryo donation.MethodsThis was a national qualitative study conducted via semistructured phone interviews. Interviews were self-nominated and composed of 25 open-ended questions. Interviews were transcribed using Temi software and coding was conducted in accordance with grounded theory methodology by five independent researchers to identify themes.Participants came from three embryo donation programmes across the USA. 28 participants, with an average age of 48 years (range: 34–69), volunteered to participate in interviews from a larger subject group. This previous group was a cross-sectional, survey-based study of psychosocial outcomes of children born via embryo donation. The majority of patients (92%) identified as Christian/Catholic.Themes were identified in participants’ responses to questions regarding general perceptions of embryo donation, decision-making process, disclosure and children’s psychosocial adjustment.ResultsOf the 118 participants from the quantitative survey-based study who volunteered for this qualitative study, 28 individuals (24%) participated in the phone interview before thematic saturation was reached. The main themes identified include a desire to use existing embryos efficiently; religious frameworks encouraging maximal embryo use; satisfaction with and enthusiasm for embryo donation; lack of concern regarding child social adjustment and willingness to disclose donor embryo use to others.ConclusionThis qualitative study’s findings affirm that participants find conceiving a child through embryo donation highly satisfying and rewarding, experiencing minimal adverse events or regrets. As respondents identified largely as Christian/Catholic, further studies are warranted to assess the perceptions of a more diverse and generalisable population of recipients and children born via embryo donation.
Impact of family childhood adversity on risk of violence and involvement with police in adolescence: findings from the UK Millennium Cohort Study
Authors: Adjei Nicholas Kofi , Jonsson Kenisha Russell , Opoku-Ware Jones , Yaya Sanni , Chen Yanhua , Bennett Davara , McGovern Ruth , Munford Luke , Black Michelle , Taylor-Robinson David 
Published: January 2025

BackgroundChildhood adversities, such as exposure to parental mental illness, domestic violence and abuse, substance use, and family poverty, have been linked to involvement in violence in early adulthood. However, evidence on the cumulative impact of multiple adversities throughout childhood on violence and crime in adolescence remains scarce. This study investigates the associations between trajectories of family adversity and poverty during childhood, and the risk of involvement in violence and contact with police in adolescence.MethodsWe used longitudinal data from the UK Millennium Cohort Study on 9316 children. Exposure trajectories of family adversities and poverty were characterised (from ages 0–14 years) using group-based multi-trajectory models. The outcomes were weapon involvement, for example, carrying a knife, and police contact measured at age 17 years. Odds ratios and 95% confidence intervals (OR, 95% CI) and population attributable fractions were estimated using logistic regression models, adjusting for confounding factors.ResultsThe prevalence of weapon involvement and contact with police at age 17 years were 6.1% and 20.0%, respectively. Compared with children who experienced low poverty and family adversity throughout childhood, those exposed to persistent poverty and poor parental mental health were at notably increased risk of carrying weapons (adjusted OR (aOR) 2.2, 95% CI 1.3 to 3.6) and reporting contact with police (aOR 2.1, 95% CI 1.6 to 2.8). We estimate that about 32% of weapon involvement and 23% of contact with police at age 17 were attributable to persistent poverty and family adversity.ConclusionExposure to poverty and poor parental mental health throughout childhood doubles the risk of weapon involvement and police contact in early adulthood. These findings emphasise the importance of lifecourse and anti-poverty approaches to reducing involvement in crime in the UK.
Transversus abdominis plane block combined with intrathecal fentanyl versus intrathecal morphine for post-cesarean analgesia: a randomized non-inferiority clinical trial
Authors: Park Sun-Kyung , Kim Youngwon , Kim Hansol , Kim Jin-Tae 
Published: January 2025

BackgroundIntrathecal morphine is the standard for post-cesarean analgesia but often causes pruritus and may be unavailable in resource-limited settings. This study assessed whether a combination of bilateral transversus abdominis plane (TAP) block and intrathecal fentanyl provides non-inferior analgesia compared with intrathecal morphine following cesarean delivery within the multimodal analgesia context.MethodsEighty mothers were randomized to receive either intrathecal fentanyl 10 µg with bilateral TAP block using 15 mL of 0.375% ropivacaine per side (TF group) or intrathecal morphine 75 µg with a saline sham block (M group). All patients received standard multimodal analgesia. Primary outcome was pain score with movement at 24 hours postoperatively, with a non-inferiority margin of 1 on the numeric rating scale. Secondary outcomes included opioid consumption, time to first opioid, pruritus, nausea/vomiting, patient satisfaction, and neonatal outcomes.ResultsThe mean pain score with movement at 24 hours was 5.4 in the TF group and 4.8 in the M group (mean difference (95% CI), 0.6 (−0.3 to 1.5), p=0.202), with the upper margin of 95% CI exceeding the non-inferior margin. Postoperative fentanyl consumption was higher in the TF group (median (IQR), 585 (390–745) vs 140 (55–405) µg; p<0.001). Pruritus was more frequent in the M group (60% vs 10%; p<0.001).ConclusionsBilateral TAP block with intrathecal fentanyl is not non-inferior to intrathecal morphine for post-cesarean analgesia. However, intrathecal morphine was associated with a higher incidence of pruritus, suggesting TAP block with intrathecal fentanyl as a suitable alternative when reducing pruritus is a priority.Trial registration numberNCT04824274.