bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying the Role of Insurance in Tornado-impacted Community Recovery: A Survey and Simulation-based Approach
Authors: Zhao Jie , Lee Ji Yun , Yan Guirong Grace , Ma Fangjiao 
Published: October 2023

Abstract
Insurance against disasters plays a critical role in community recovery by providing policyholders with reliable and timely payments for repairing or reconstructing damaged houses. By allowing homeowners to transfer risk, insurance enables homeowners to repair or reconstruct damaged houses without experiencing significant financial hardship. Although historical events have highlighted the importance of insurance, its quantitative impact on community recovery, particularly in tornado-impacted communities, is understudied. This study focuses on advancing our understanding of whether sufficiently insured houses can have a positive impact on the recovery of tornado-impacted communities (i.e., the main research question). This paper proposes a two-stage simulation framework to quantitatively evaluate the effects of insurance on community recovery. In the first stage of the framework, we developed statistical models to estimate homeowners’ insurance decisions prior to a tornado event. In the second stage, we examined the effects of insurance on various aspects of community recovery. All the empirical and statistical models within the framework were developed based on the data collected from online surveys targeting residents whose properties were damaged by the tornadoes that occurred in May 2019 in the United States. Finally, the proposed simulation framework was applied to the City of Dayton, Ohio following those May 2019 tornado events to address the main research question. The results of the simulation concluded that sufficiently insured houses can have a positive impact on community recovery and highlighted the need for effective policies and economic incentives to encourage individuals to purchase insurance.
Oncomelania lorelindoensis: the intermediate host of Sulawesi’s Schistosoma japonicum
Authors: Nelwan Martin 
Published: October 2023

Abstract
Purpose: In this study, I report a study of the genus Oncomelania focused on Schistosoma japonicum and Oncomelania lorelindoensis as the intermediate hosts of Sulawesi schistosomiasis japonica, their distributions in Sulawesi, and control of O. lorelindoensis.
Principal results: Proto-Oncomelania originated in eastern Indonesia, Sulawesi. It spread to the Philippines, Japan, and China, and then gave rise to Oncomelania. It is the intermediate host of Schistosoma japonicum. The genus Oncomelania comprises five species: Oncomelania hupensis, O. lorelindoensis (formerly O. hupensis lindoensis), O. minima, O. robertsoni, and O. quadrasi. Oncomelania lorelindoensis is the intermediate host of Sulawesi S. japonicum. It occurs in and around the Lore Lindu National Park: the Bada Valley, the Lindu Valley, and the Napu Valley, Central Sulawesi. This organism may have prevailed in the Kulawi Valley and the Palu Valley of Central Sulawesi Province. Control of O. lorelindoensis can use mechanic techniques, molluscicides, and genetic manipulation techniques.
Conclusions: Oncomelania lorelindoensisoccurs in Central Sulawesi, Indonesia: the Bada Valley, the Lindu Valley, and the Napu Valley. It may also have expanded to other areas around Lore Lindu National Park. This organism is the intermediate host of Sulawesi S. japonicum.
Effects of low-dose Esketamine on postoperative analgesia and sleep quality in patients undergoing total hip arthroplasty
Authors: Wei Qiufeng , Wang binbin , Feng sisi , Dai weixin , Lin cheng xin , He wen zheng 
Published: October 2023

Abstract
Background: Total hip arthroplasty (THA) is widely acknowledged as the primary treatment for end-stage joint diseases.Perfect postoperative analgesia can significantly decrease the incidence of adverse complications after hip replacement.We hypothesized that administering Esketamine in patient-controlled analgesia after hip replacement can alleviate postoperative pain and improve sleep quality in patients.
Methods: We recruited 72 patients undergoing unilateral total hip arthroplasty under combined general and peripheral nerve block anaesthesia. The patients were assigned to either the F-D group (fentanyl combined with dexmedetomidine，n=34) or the Es-D group (Esketamine combined with dexmedetomidine，n=38) using a random number table method. The primary outcome measures included the time to the first use of rescue analgesics and the dose of rescue analgesics.
Results: Patients in the Es-D group had a significantly shorter time to request the first postoperative rescue analgesic than those in the F-D group (P＜0.05). The dose of rescue analgesics used in the Es-D group was considerably lower than that in the F-D group (P＜0.05).The two groups had no significant differences in postoperative sleep quality and adverse reactions. However, four cases of urinary retention were observed in the F-D group, which was significantly higher than in the Es-D group (P＜0.05).
Conclusion: Esketamine provided a better analgesic effect than fentanyl and did not increase postoperative adverse reactions but can not improve the sleep quality for patients.
Trial registration:The clinical trial was registered at the China Clinical Trial Registration Center on 24/02/2021. (ChiCTR2100043649).http://www.chictr.org.cn/showproj.aspx?proj=122393.
Iconographic validation of the Bristol scale in patient with neurological diseases
Authors: Dekimeche Inès , Grasland Matthieu , Jolu Anna , Essid Dalel , Chesnel Camille , Haddad Rebecca , Breton Frédérique Le , Miget Gabriel , Amarenco Gérard 
Published: October 2023

Abstract
Introduction :
The Bristol Stool Scale, published by Heaton et al. in 1988 in a population of patients suffering from irritable bowel syndrome, is a self-assessment tool to estimate stool appearance and therefore the transit time.
It is a widely used scale recommended in the 2016 ROME IV criteria to diagnose chronic constipation.
Although initially validated in a large population of patients with gastrointestinal disorders, its specific evaluation in a population suffering from neurological diseases has never been validated.
Methods :
Subjects were asked to orally categorize nine color photos of stool with various consistencies, viewed on a computer screen, according to the Bristol scale that was provided to them in paper and in color. Then, they were asked about the comprehension of the scale, its acceptability, its completeness, and the difficulty to position themselves on a single category.
The primary endpoint was the agreement of subjects’ responses by the intraclass agreement coefficient (ICC) on the scoring of a sample of stool photographs by the Bristol scale.
Secondary end points were comprehension, acceptability and appropriateness collected during qualitative interviews with subjects.
Results:
The calculated intra-class correlation index was 0.92. For the stool photographs at the extremities of the scale (Bristol 1 and 7) all subjects responses were the same.
The scale was considered as not difficult to be understood and well accepted in the population.
Conclusion :
The Bristol scale can be used in subjects with neurological diseases, as it is well understood and accepted by this population. It can be helpful in the management of rehabilitation and medical treatment of constipation and/or fecal incontinence observed in this population.
High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade
Authors: Wang Guanjie , Ren Xiaojuan , Li Jianying , Cui Rongrong , Zhao Xumin , Sui Fang , Liu Juan , Chen Pu , Yang Qi , Ji Meiju , Hou Peng , Gao Ke , Qu Yiping 
Published: October 2023

Abstract
Gliomas are the most common primary intracranial tumor. The maintenance of telomeres serve as an important biomarker of glioma subtypes. However, the biological role of the maintenance of telomere length gene regulator of telomere length 1 (RTEL1) in glioma remains unclear. Thus, we use quantitative RT-PCR (qRT-PCR), immunohistochemistry (IHC) and western blot to determine RTEL1 expression in a cohort of glioma patients. And the biological functions of RTEL1 in glioma cells were then examined by a series of in vitro and in vivo assays. We observed that the expression of RTEL1 is positively correlated with telomere length in glioma tissue, and serve as a poor prognostic factor in TERT wild-type patients. Functional assays demonstrate that RTEL1 plays an oncogene role in glioma cell lines. In addition, RNA sequence and microarray assays were taken to identify its downstream targets. We identified phosphorylation of JNK/ELK1 signaling might be one of the mechanisms regulated by RTEL1 in glioma cells. In conclusion, Our results suggested that RTEL1 promotes glioma tumorigenesis through JNK/ELK1 cascade and indicate that RTEL1 may be a prognostic biomarker in gliomas.
Algorithms for treatment of Neonatal Opioid Withdrawal Syndrome (NOWS) based on Modified and Abbreviated Finnegan Symptom Score
Authors: Kraft Walter , Maisel Brenton , Adeniyi-Jones Susan , Selvage Eric , Ng Samuel , Chervoneva Inna 
Published: October 2023

Abstract
OBJECTIVE
Chervoneva et al (2020) developed an abbreviated score (sMNAS-9) for evaluating NOWS symptoms. We sought to develop NOWS treatment algorithms for clinical decision rules based on sMNAS-9 instead of the full modified Finnegan MOTHER NAS scale (MNAS) scores.
STUDY DESIGN:
This was a retrospective study of 373 infants with NOWS treated with morphine between 2007–2016. The infants were randomly split into training/test sets. The training set was used to derive cutoff values for sMNAS-9 scores for optimal sensitivities and specificities. The independent test set evaluated the agreement of the clinical decision rules based on sMNAS-9 with full MNAS in NOWS morphine and buprenorphine treatment algorithms.
RESULT
Clinical decision rules based on sMNAS-9 yielded sensitivities of 88% or higher and specificities of 85% or higher for predicting the respective rules based on full MNAS.
CONCLUSION
The sMNAS-9 scoring instrument is expected to yield similar clinical decisions in treatment of NOWS
Triaging Effect of High-Risk HPV Genotyping on Women with Atypical Squamous Cells of Undetermined Significance in Rural China
Authors: Yang Hongmei , Hao Yubing , Niu Meili , Zheng Jie , Jia Xinhua , Zhang Shaokai , Wang Libing , Zhang Xun , Pan Qinjing , Feng Xiangxian , Qiao Youlin , Li Zhifang 
Published: October 2023

Abstract
Objective
We evaluated the diagnostic value of high-risk human papillomavirus (HR-HPV) genotyping in women with atypical squamous cells of undetermined significance (ASC-US) in rural China.
Methods
The subjects were women with ASC-US cytology who received cervical cancer screening in rural areas of Changzhi, China. Liquid-based cytology, HPV genotyping, and colposcopy were performed. Patients with positive colposcopy further underwent histopathological examination. Pathological diagnosis was the gold standard. Cervical intraepithelial neoplasia grade 2 or higher (CIN2+) on histology were endpoints. The sensitivity, specificity, area under the ROC curve, positive predictive value, negative predictive value, and referral rate of different HR-HPV genotyping were calculated.
Results
Among the 571 enrolled women with ASC-US, the total positive rate of HR-HPV was 49.31%. Among the women with CIN2 + lesions, the positive rate of HR-HPV was 93.54%. Among several common combination models of genotyping, HPV16/18 had the highest specificity (90.19%) and positive predictive value (17.92%), and the lowest referral rate (12.78%) in women with ASC-US. Among all different HPV genotyping combinations, the sensitivity, negative predictive value, and the area under the ROC curve had no significant difference.
Conclusions
HPV16/18 is a cost-effective diagnostic triaging strategy for women with ASC-US in rural areas with a lack of medical resources and an underdeveloped economy.
Up-regulated mRNA expression of VEGFA receptors (FLT1 and KDR) in placentas after assisted reproductive technology fertilization
Authors: Mrozikiewicz Aleksandra E. , Kurzawińska Grażyna , Walczak Michał , Zielińska-Skrzypczak Marzena , Ożarowski Marcin , Jędrzejczak Piotr 
Published: October 2023

Abstract
Objective
Placental angiogenesis is a pivotal process for feto-maternal circulation and ensures efficient development of the placenta throughout pregnancy. Many factors during in vitro fertilization and embryo transfer procedures may affect placental gene expression and fetus development. The present study aimed to identify differences in angiogenesis-related gene (VEGFA, FGF2, FLT1 and KDR) expression profiles in placentas after assisted reproductive technology fertilization and natural conception in healthy women.
Methods
In a case-control study, term placentas were collected from Caucasian women after assisted reproductive technology fertilization (N = 20) and after natural conception in women with uncomplicated pregnancy (N = 9). The mRNA expression in placentas was examined for VEGFA, FGF2, FLT1 and KDR genes by real-time quantitative polymerase chain reaction (RT-qPCR). Group stratification was performed for comparison of investigated genes between the type of embryo transferred (fresh/frozen), place of tissue donation (center/margin) and newborns’ gender (male/female).
Results
In the ART placentas significant down-regulation of VEGFA gene (p = 0.016) and up-regulation of FLT1 (p = 0.026) and KDR (p < 0.001) gene receptors were observed. Genes encoding VEGFA receptors were up-regulated in both fresh (ET) and frozen (FET) embryo transfer groups compared to controls. For the FLT1 gene a statistically significant difference was observed between the frozen embryo transfer group and the controls (p = 0.032). Relative expression of KDR was significantly higher for both embryo transfer groups compared to controls (p < 0.001) and between ET and FET (p = 0.002). No statistically significant differences were observed between placental expression in different places of tissue donation and newborns’ gender.
Conclusion
We observed differences in the placental expression of VEGFA and its receptors FLT1 and KDR in pregnancies after assisted reproductive technology compared to naturally conceived pregnancies. More research is needed to clarify these alterations that may affect placental development and fetal health.
Identification and Characterization of Achromobacter spanius P-9 and Elucidation of its Deoxynivalenol-Degrading Potential
Authors: Yao Feng , Du Yaowen , Tian Siyi , Chang Guoli , Zhang Yanping , Zhu Ruiyu , Cai Chenggang , Shao Suqin , Zhou Ting 
Published: October 2023

Abstract
Deoxynivalenol (DON) poses significant challenges due to its frequent contamination of grains and associated products. Microbial strategies for mitigating DON toxicity showed application potential. Eight bacterial isolates with DON degradation activity over 5% were obtained from various samples of organic fertilizer in this study. One of the isolates emerged as a standout, demonstrating a substantial degradation capability, achieving a 99.21% reduction in DON levels. This isolate, underwent thorough morphological, biochemical, and molecular characterization to confirm its identity, and was identified as a new strain of Achromobacter spanius P-9. Subsequent evaluations revealed that the strain P-9 retains its degradation activity after a 24-hour incubation, reaching optimal performance at 35°C with a pH of 8.0. Further studies indicated that Ca2+ ions enhance the degradation process, whereas Zn2+ ions exert an inhibitory effect. This is the pioneering report of DON degradation by Achromobacter spanius, illuminating its prospective utility in addressing DON contamination challenges.
A Novel Active Learning Approach for Improving Classification of Unlabeled Video Based on Deep Learning Techniques
Authors: Salama Mohamed 
Published: October 2023

Abstract
Deep learning has made great strides in computer vision, but requires substantial labeled data. Manual video annotation is extremely laborious, as annotators must watch entire videos to provide accurate labels. Active learning reduces this effort by selectively querying the most informative examples for labeling. We introduce a unique active learning framework designed specifically for enhancing the efficiency of video classification. It minimizes annotator effort by identifying representative and informative frames, rather than full videos. Our batch selection approach pinpoints useful videos using uncertainty and diversity criteria. Representative sampling then extracts exemplar frames from each video. Annotators only need to label these frames, avoiding watching full videos. Experiments demonstrate our method successfully reduces human annotation cost for video classification. By querying informative, representative frames, it acquires crucial labels without needing exhaustive manual review of all data. We introduce an active learning technique specifically for alleviating the video annotation burden. By requesting labels for a small set of exemplar frames, it achieves high accuracy while minimizing human effort. This makes large-scale video classification more feasible.
Does matrilineality reduce gender inequality in Environmental and Social Impact Assessment (ESIA) public participation? Some evidence from Malawi
Authors: Sibale Juwo Lwesya , Fischer Thomas B 
Published: October 2023

Abstract

This paper reports on Environmental and Social Impact Assessment (ESIA) public participation in Malawi with a focus on the role of women from matrilineal and patrilineal marriage systems. Six rural ESIA projects are explored of which three are in areas of patrilineal and three are in areas of matrilineal systems. Participation space was found to be consistently dominated by men, with no obvious differences between both systems. The key reasons are likely to be lower educational and social status of women in rural areas throughout the country. This is associated with a number of challenges, including chronic poverty and food insecurity. Affirmative action is needed to achieve a better representation of women in ESIA processes.
Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy against non-small cell lung cancer
Authors: Pan Hanbo , Tian Yu , Pei Siyu , Yang Wanlin , Zhang Yanyang , Gu Zenan , Zhu Hongda , Zou Ningyuan , Zhang Jiaqi , Jiang Long , Hu Yingjie , Shen Shengping , Wang Kai , Jin Haizhen , Li Ziming , Zhang Yanyun , Xiao Yichuan , Luo Qingquan , Wang Hui , Huang Jia 
Published: October 2023

Abstract
Background
Non-small cell lung cancer (NSCLC) is one of the predominant malignancies globally. Percutaneous thermal ablation (PTA) has gained widespread use among NSCLC patients, with the potential to elicit immune responses but limited therapeutic efficacies for advanced-stage disease. T-helper type 9 (Th9) cells are a subset of CD4+ effector T cells with robust and persistent anti-tumor effects. This study proposes to develop PTA-Th9 cell integrated therapy as a potential strategy for NSCLC treatment.
Methods
The therapeutic efficacies were measured in mice models with subcutaneously transplanted, recurrence, or lung metastatic tumors. The tumor microenvironments (TMEs) were evaluated by flow cytometry. The cytokine levels were assessed by ELISA. The signaling molecules were determined by quantitative PCR and Western blotting. The translational potential was tested in the humanized NSCLC patient-derived xenograft (PDX) model.
Results
We find that PTA combined with adoptive Th9 cell transfer therapy substantially suppresses tumor growth, recurrence, and lung metastasis, ultimately extending the survival of mice with NSCLC grafts, outperforming both PTA and Th9 cell transfer monotherapy. Analysis of TMEs indicates that combinatorial therapy significantly augments tumor-infiltrating Th9 cells, boosts anti-tumor effects of CD8+ T cells, and remodels tumor immunosuppressive microenvironments. Moreover, combinatorial therapy significantly strengthens the regional and circulation immune response of CD8+ T cells in mice with tumor lung metastasis and induces peripheral CD8+ T effector memory cells in mice with tumor recurrence. Mechanically, PTA reinforces the anti-tumor ability of Th9 cells primarily through upregulating interleukin (IL)-1β and subsequently activating the downstream STAT1/IRF1 pathway, which could be effectively blocked by intercepting IL-1β signaling. Finally, the enhanced therapeutic effect of combinatorial therapy is validated in humanized NSCLC PDX models.
Conclusions
Collectively, this study demonstrates that combinatorial therapy displays robust and durable anti-tumor efficacy and excellent translational potential, offering excellent prospects for translation and emerging as a promising approach for NSCLC treatment.
Bone Metabolism Biomarkers after Parathyroidectomy: The Impact on Patient Survival
Authors: Zhang Weichen , Zhang Minmin , Wang Hongying , Mao Jianping , Qian Jing , Ni Li , Wang Mengjing , Chen Jing 
Published: October 2023

Abstract
Background
The purpose of this study was to explore the risk factors from a series of bone metabolism indicators in perioperative period for long-term prognosis and develop a prediction model with internal validation among hemodialysis patients underwent parathyroidectomy.
Methods
This study was a single-center, retrospective cohort study in Huashan Hospital of Fudan University. Patients who underwent parathyroidectomy and followed for at least one year were enrolled and divided into development cohort and validation cohort. Multivariable Logistic regression was used to establish the prediction model for composite endpoint of cardiovascular disease and all-cause mortality and operating characteristic (ROC) curve to determine the cut-off value of each predictive variable.
Results
A total of 109 patients were enrolled. The averaged follow-up vintage was (51.67 ± 34.70) months. A total of 16 (14.7%) patients died and cardiovascular disease occurred in 15 (13.8%) patients. The final development and validation cohorts included 82 and 27 patients, respectively. Multivariable Logistic regression analysis showed age (OR = 1.086, P = 0.048, 95%CI = 1.001–1.179), △P which was defined as the difference between preoperative and the 7th-day postoperative serum phosphorus levels (OR = 2.665, P = 0.028, 95%CI = 1.111–6.397), 7th-day postoperative intact parathyroid hormone (iPTH) of grafted arm (OR = 1.024, P = 0.036, 95%CI = 1.002–1.047) and 7th-day postoperative bone-specific alkaline phosphatase (BAP) (OR = 0.95, P = 0.04, 95%CI = 0.905–0.998) were correlated with CVD and all-cause mortality. △P which contributed to 36% of the total weights had the greatest impact on the endpoint.
Conclusion
Age, △P, 7th-day postoperative iPTH of grafted arm, 7th-day postoperative BAP can predict long-term cardiovascular events and all-cause mortality in hemodialysis patients after parathyroidectomy.