bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review
Authors: Coppola L. , Lori G. , Tait S. , Sogorb M. A. , Estevan C. 
Published: January 2025

Abstract
Chlorpyrifos (CPF) is an organophosphorus pesticide of concern because many in vivo animal studies have demonstrated developmental toxicity exerted by this substance; however, despite its widespread use, evidence from epidemiological studies is still limited. In this study, we have collected all the information generated in the twenty-first century on the developmental toxicity of CPF using new approach methodologies. We have critically evaluated and integrated information coming from 70 papers considering human, rodent, avian and fish models. The comparison of the collected evidence with available adverse outcome pathways allows us to conclude that adverse outcomes observed in animals, such as memory and learning impairments as well as reduction in cognitive function, could involve several mechanisms of action including inhibition of acetylcholinesterase, overactivation of glutamate receptors and activation of mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, followed by both disruption of neurotransmitter release and increase in oxidative stress and apoptosis.
The activity of indigo carmine against bacteriophages: an edible antiphage agent
Authors: Raza Sada , Bończak Bartłomiej , Atamas Nataliia , Karpińska Aneta , Ratajczyk Tomasz , Łoś Marcin , Hołyst Robert , Paczesny Jan 
Published: January 2025

Abstract
Bacteriophage infections in bacterial cultures pose a significant challenge to industrial bioprocesses, necessitating the development of innovative antiphage solutions. This study explores the antiphage potential of indigo carmine (IC), a common FDA-approved food additive. IC demonstrated selective inactivation of DNA phages (P001, T4, T1, T7, λ) with the EC50 values ranging from 0.105 to 0.006 mg/mL while showing no activity against the RNA phage MS2. Fluorescence correlation spectroscopy (FCS) revealed that IC selectively binds to dsDNA, demonstrated by a significant reduction in the diffusion coefficient, whereas no binding was observed with ssDNA or RNA. Mechanistically, IC permeates the phage capsid, leading to genome ejection and capsid deformation, as confirmed by TEM imaging. Under optimal conditions (50 °C, 220 rpm), IC achieved up to a 7-log reduction in phage titer, with kinetic theory supporting the enhanced collision frequency induced by agitation. Additionally, IC protected E. coli cultures from phage-induced lysis without affecting bacterial growth or protein production, as demonstrated by GFP expression assays. IC’s effectiveness and environmental safety, combined with its FDA approval and cost-effectiveness, make it a promising antiphage agent for industrial applications.

Key points
• Indigo
carmine effectively inactivates a broad spectrum of bacteriophages, offering protection to bacteria in industrial cultures.

• A novel application of indigo carmine as a food-grade, environmentally safe, and FDA-approved antiphage agent protecting bacterial cultures.

• Antiphage activity arises from indigo carmine’s interaction with DNA within the phage capsid without harming bacterial cells or compromising protein production in bacterial cultures.

Graphical abstract
Platelet-rich plasma does not influence magnetic resonance imaging findings of the gluteus muscles after total hip arthroplasty through the Hardinge approach
Authors: Nieminen Anette , Nurminen Janne , Aavikko Anni , Puhakka Jani , Haapala Jussi , Keemu Hannes , Kukkonen Juha , Alho Ari , Uusalo Panu , Mäkelä Keijo , Kosola Jussi 
Published: January 2025

Abstract

Objective
Total hip arthroplasty through the Hardinge approach damages the hip abductor muscles. MRI can be used to assess adverse postoperative events. In this prospective randomized controlled trial, we evaluated MRI findings and whether platelet-rich plasma affected postoperative healing of the gluteal muscles (gluteus medius and minimus).

Materials and methods
Forty patients with hip osteoarthritis requiring treatment with total hip arthroplasty, aged between 60 and 76 years, were included. Patients were randomized into two groups: 19 patients in the platelet-rich plasma group and 21 in the placebo group. Platelet-rich plasma or placebo was injected into the gluteus medius tendon incision line during closure. Postoperative hip MRI and plain radiographs were taken 3 and 12 months after surgery.

Results
MRI showed fatty atrophy of the gluteal muscles in all 40 patients (100%), gluteal muscle tear in 11 patients (28%), and atrophy in 16 patients (40%) at both 3 and 12 months postoperatively. Fluid collections related to the operated hip joint were seen in 18 patients (45%) at 3 months and 13 patients (33%) at 12 months, heterotopic ossification formation in nine patients (23%) at 3 months, and 12 patients (31%) at 12 months. There were no significant differences in imaging findings between the two groups.

Conclusion
MRI can be a valuable tool for evaluating postoperative healing after total hip arthroplasty. Fatty atrophy of the gluteal muscles was a common finding. Platelet-rich plasma injection into the gluteus medius tendon did not improve healing detected by MRI.
T1 signal intensity ratio variability based on sampling strategies in the pancreas of children and young adults
Authors: Mathur Arjun K. , Dillman Jonathan R. , Abu-El-Haija Maisam , Vitale David S. , Tkach Jean A. , Trout Andrew T. 
Published: January 2025

Abstract

Purpose
T1-weighted signal intensity ratios (SIR) comparing pancreas to spleen (SIRps) or muscle (SIRpm) can semiquantitatively assess T1 signal change associated with pancreatitis. However, there is no standardized methodology for generating these ratios. We set out to determine the impact of MRI sequence as well as region of interest (ROI) location, shape, and size on T1 SIR.

Methods
Retrospective analysis of T1-weighted MR images from 118 patients acquired 2018–2023. A single observer placed ovoid ROIs in the pancreas body/tail and head/uncinate, spleen, and left erector spinae muscle and large irregular ROIs in the pancreas tail and spleen. ROIs were placed on images from two sequences: 3D radial 2 point mDIXON RF spoiled gradient recalled echo sequence (radial) and breath-hold 3D 2-point mDIXON RF spoiled gradient echo (BH). T1 SIR were calculated from mean signal intensity, and agreement was calculated with intraclass correlations coefficients (ICC) and Bland–Altman difference analyses.

Results
118 participants, 57 (48%) female, with mean age 13.7 ± 5.6 years (48%) were included. Agreement was good for SIRps based on irregular versus round ROIs (radial: ICC = 0.90; BH: ICC = 0.91). Agreement was moderate for SIR based on sampling the pancreas body/tail versus head/uncinate (ICC = 0.67–0.76) and poor to moderate based on reference organ (muscle vs. spleen) (ICC = 0.41–0.61). Between sequences, agreement was moderate (ICC = 0.55–0.72, mean difference 0.04–0.09).

Conclusion
The size and shape of the ROI used to sample the pancreas does not meaningfully change T1 SIR but the location sampled, the reference organ used, and the MRI sequence used meaningfully change T1 SIR, potentially impacting disease diagnosis and staging.

Graphical abstract
Comparison of complications and surgery outcomes in skin closure methods following cesarean sections
Authors: Gabbai Daniel , Jacoby Chen , Gilboa Itamar , Maslovitz Sharon , Yogev Yariv , Attali Emmanuel 
Published: January 2025

Abstract

Purpose
This study aimed to assess the impact of absorbable subcutaneous staples for skin closure in cesarean delivery (CD) on maternal morbidity.

Methods
A retrospective cohort study was conducted at a single tertiary university-affiliated medical center between January 2011 and April 2022. In 2020, a new technique involving absorbable subcutaneous staples for skin closure in CD was introduced. We compared surgical outcomes among three groups: non-absorbable staples, absorbable subcutaneous staples, and absorbable subcutaneous sutures. Data were compared between the three groups and demographic, obstetric, and surgical characteristics were analyzed using univariate and multivariate analysis.

Results
During the study period, 31,660 CDs were performed in our center. The data of 31,419 CDs were available for analysis. Absorbable subcutaneous staples were associated with a significantly shorter surgery time in comparison to non-absorbable staples and sutures (52 min vs 53 min vs 60 min, p < 0.001). No differences were found in rates of wound infections or any surgical site surgery in the 45 days following CD. In a multivariate analysis: the use of absorbable subcutaneous staples was associated with a significantly lower risk for prolonged hospitalization > 5 days (OR 0.6, p < 0.001) and re-admission within 45 days (OR 0.8, p = 0.04).

Conclusion
The use of absorbable subcutaneous staples for skin closure during CD is associated with shorter surgery times and a lower risk of prolonged hospitalization and readmission within 45 days.
Long-term symptoms in children after a Cryptosporidium hominis outbreak in Sweden: a 10-year follow-up
Authors: Boks Marije , Lilja Mikael , Lindam Anna , Widerström Micael , Persson Angelica , Karling Pontus , Sjöström Malin 
Published: January 2025

Abstract
In 2010, a Cryptosporidium
hominis outbreak resulted in 27,000 clinical cryptosporidiosis cases (45% of the population) in Östersund, Sweden. Long-term abdominal and joint symptoms are common following cryptosporidiosis in adults, and it can affect the development of children in low-income countries. We investigated the potential consequences for children in a high-income setting. In 2011, we prospectively surveyed 600 randomly selected children aged 0–5 years from Östersund. Cases were defined as respondents reporting new episodes of diarrhoea during the outbreak. After 10 years, respondents received a follow-up questionnaire about long-term symptoms (n = 423). We used X
2 and Mann–Whitney U tests to assess between-group differences in demographics and the mean number of symptoms. Logistic regressions adjusted for sex, age, and prior issues with loose stools were used to examine associations between case status and symptoms reported at follow-up. We retrieved data on healthcare visits from patient records. In total, 121 cases and 174 non-cases responded to the follow-up questionnaire (69.7%). Cases reported 1.74 (median 1.00, range 0–14) symptoms and non-cases 1.37 (median 0.00, range 0–11) symptoms (p = 0.029). Cases were more likely to report joint symptoms (aOR 4.0, CI 1.3–12.0) and fatigue (aOR 1.9, CI 1.1–3.4), but numbers were generally low. We found no between-group differences in abdominal symptoms, healthcare utilization, or disease diagnoses. Children aged 0–5 years from high-income countries may experience long-term symptoms after cryptosporidiosis, but may not be affected to the same extent as adults or their peers living in low-income countries.
Extreme heat risk and the potential implications for the scheduling of football matches at the 2026 FIFA World Cup
Authors: Mullan Donal , Barr Iestyn , Brannigan Neil , Flood Nuala , Gibson Oliver R. , Hambly Catherine , Kennedy-Asser Alan T. , Kielt Aimée C. , Matthews Tom , Orr Madeleine 
Published: January 2025

Abstract
Climate change is making extreme heat events more frequent and intense. This negatively impacts many aspects of society, including organised sport. As the world’s most watched sporting event, the FIFA World Cup commands particular attention around the threat of extreme heat. The 2022 tournament in Qatar was moved from summer to winter in response to this threat, and now attention turns to the 2026 tournament in North America with extreme heat risk across many of the 16 host locations. We examine this risk by modelling wet bulb globe temperature (WBGT) – a widely used measure of heat stress – for the host locations using hourly meteorological data for the period 2003–2022. Our results show that 14 out of 16 host locations exceed WBGTs of 28 °C, with four (nine) exceeding this threshold more than half the time during afternoons across the mean (hottest year) of the 20 year record. This threshold is important as the level beyond which some football governing bodies recommend match delay or postponement. A climatically sound argument is therefore presented to reschedule kick-off times outside the hottest afternoon hours for the host locations with highest heat risk at which no indoor air conditioned environment exists – primarily Miami and Monterrey, but also Philadelphia, Kansas City, Boston and New York. This study highlights the need to carefully assess heat risk ahead of major sporting events to help inform any potential interventions needed in the scheduling of matches and competitions in a warming climate.
Regularity for minimizers of a planar partitioning problem with cusps
Authors: Novack Michael 
Published: January 2025

Abstract
We study the regularity of minimizers for a variant of the soap bubble cluster problem:

$$\begin{aligned} \min \sum _{\ell =0}^N c_{\ell } P( S_\ell )\,, \end{aligned}$$

min

∑

ℓ
=
0

N

c
ℓ

P

(

S
ℓ

)

,

where

$$c_\ell >0$$

c
ℓ

>
0

, among partitions

$$\{S_0,\dots ,S_N,G\}$$

{

S
0

,
⋯
,

S
N

,
G
}

of

$$\mathbb {R}^2$$

R

2

satisfying

$$|G|\le \delta $$

|
G
|
≤
δ

and an area constraint on each

$$S_\ell $$

S
ℓ

for

$$1\le \ell \le N$$

1
≤
ℓ
≤
N

. If

$$\delta >0$$

δ
>
0

, we prove that for any minimizer, each

$$\partial S_{\ell }$$

∂

S
ℓ

is

$$C^{1,1}$$

C

1
,
1

and consists of finitely many curves of constant curvature. Any such curve contained in

$$\partial S_{\ell } \cap \partial S_{m}$$

∂

S
ℓ

∩
∂

S
m

or

$$\partial S_\ell \cap \partial G$$

∂

S
ℓ

∩
∂
G

can only terminate at a point in

$$\partial G \cap \partial S_\ell \cap \partial S_{m}$$

∂
G
∩
∂

S
ℓ

∩
∂

S
m

at which G has a cusp. We also analyze a similar problem on the unit ball B with a trace constraint instead of an area constraint and obtain analogous regularity up to

$$\partial B$$

∂
B

. Finally, in the case of equal coefficients

$$c_\ell $$

c
ℓ

, we completely characterize minimizers on the ball for small

$$\delta $$

δ

: they are perturbations of minimizers for

$$\delta =0$$

δ
=
0

in which the triple junction singularities, including those possibly on

$$\partial B$$

∂
B

, are “wetted”by G.
Is there an impact of the Structural Funds in innovation on business performance? Analysis through the ERDF-Innterconecta programme in Andalusia
Authors: Sande Veiga Diego 
Published: January 2025

Abstract
Andalusia, a Spanish Autonomous Community with a Convergence objective under the European Union, has had to manage a relevant volume of European resources for regional innovation throughout the last two European Programming periods, namely 2007–2013 and 2014–2020. For this reason, studying the impact on business results of European Funds for innovation is key to understanding the policy effects. This is why the ERDF-Innterconecta programme (the largest programme financed to support business innovation in Spain), belonging to the Technology Fund and the Smart Growth Programme, is analyzed. The proposed analysis seeks to identify whether there has been an impact of the subsidies on Andalusian companies. In this sense, two indicators have been studied: annual results and profitability. To this end, the beneficiary companies have been studied according to their size, participation in innovation and role in the financed projects, which constitutes an original research approach. The study shows poor results for the participating companies, which would indicate a wide margin for improvement in the planning and execution of these policies.
Anti-angiogenic therapy as potential treatment for adenomyosis
Authors: Harmsen Marissa J. , Juffermans Lynda J. M. , Kroon Muara O. , Griffioen Arjan W. , Huirne Judith A. F. 
Published: January 2025

Abstract
Adenomyosis is characterized by abnormal uterine bleeding, dysmenorrhea and subfertility. Increased expression of angiogenesis markers in adenomyosis presents a treatment opportunity and was studied in an adenomyosis mouse model. Mice were administered tamoxifen (1 mg/kg) on neonatal days 2–5. At six weeks of age, mice received oral treatment with axitinib 3 mg/kg (‘dose I/AX3’, n = 34), axitinib 25 mg/kg (‘dose II/AX25’ n = 34), or with vehicle-only (‘placebo’, n = 34). The prevalence and severity of adenomyosis were assessed. An adenomyosis severity index was calculated by multiplying mean grade/mouse by the percentage affected surface area. Angiogenesis-related gene expression was evaluated using real-time quantitative PCR. 101 mice completed adenomyosis induction and could be analyzed. The prevalence of adenomyosis was 30/33 (90.0%) in dose I, 29/34 (85.3%) in dose II, and 30/34 (88.2%) in placebo treated mice (p = 0.78). High grade (2/3) adenomyosis was significantly less prevalent in mice treated with axitinib dose II (n = 19, 55.9%) than in the placebo group (n = 27, 79.4%, p < 0.05). The adenomyosis severity index was reduced by 48% in the axitinib-treated groups (dose I, p < 0.05). The expression of angiogenic growth factors was reduced in the dose I and II axitinib-treated groups compared to the placebo-treated group. Following these promising first results, further research should focus on commonality among different angiostatic drugs, potential side effects, as well as the method and timing of application.
Transfer learning in agriculture: a review
Authors: Hossen Md Ismail , Awrangjeb Mohammad , Pan Shirui , Mamun Abdullah Al 
Published: January 2025

Abstract
The rapid growth of the global population has placed immense pressure on agriculture to enhance food production while addressing environmental and socioeconomic challenges such as biodiversity loss, water scarcity, and climate variability. Addressing these challenges requires adopting modern techniques and advancing agricultural research. Although some techniques, such as machine learning and deep learning, are increasingly used in agriculture, progress is constrained by the lack of large labelled datasets. This constraint arises because collecting data is often time-consuming, labour-intensive, and requires expert knowledge for data annotation. To mitigate data limitations, transfer learning (TL) offers a viable solution by allowing pre-trained models to be adapted for agricultural applications. Many researchers have demonstrated TL’s potential to advance agriculture. Despite its importance, there is a lack of a comprehensive review, which could be essential to guide researchers in this field. Given the significance and the lack of a review paper, this paper provides a review dedicated to TL in agriculture, offering three main contributions. First, we provide an in-depth background study on TL and its applications in agriculture. Second, we offer a comprehensive examination of TL-based agricultural applications, covering pre-trained models, dataset sources, input image types, implementation platforms, and TL approaches. Third, based on an exploration of the existing studies, we identify the challenges faced when applying TL in agriculture. Finally, to address the identified challenges, we recommend suggestions for future research directions.
Intelligent Cinematography: a review of AI research for cinematographic production
Authors: Azzarelli Adrian , Anantrasirichai Nantheera , Bull David R. 
Published: January 2025

Abstract
This paper offers the first comprehensive review of artificial intelligence (AI) research in the context of real camera content acquisition for entertainment purposes and is aimed at both researchers and cinematographers. Addressing the lack of review papers in the field of intelligent cinematography (IC) and the breadth of related computer vision research, we present a holistic view of the IC landscape while providing technical insight, important for experts across disciplines. We provide technical background on generative AI, object detection, automated camera calibration and 3-D content acquisition, with references to assist non-technical readers. The application sections categorize work in terms of four production types: General Production, Virtual Production, Live Production and Aerial Production. Within each application section, we (1) sub-classify work according to research topic and (2) describe the trends and challenges relevant to each type of production. In the final chapter, we address the greater scope of IC research and summarize the significant potential of this area to influence the creative industries sector. We suggest that work relating to virtual production has the greatest potential to impact other mediums of production, driven by the growing interest in LED volumes/stages for in-camera virtual effects (ICVFX) and automated 3-D capture for virtual modeling of real world scenes and actors. We also address ethical and legal concerns regarding the use of creative AI that impact on artists, actors, technologists and the general public.
Adaptive graph diffusion networks: compact and expressive GNNs with large receptive fields
Authors: Sun Chuxiong , Zhang Muhan , Hu Jie , Gu Hongming , Chen Jinpeng , Yang Mingchuan 
Published: January 2025

Abstract
Graph neural networks (GNNs) are widely used in graph-based tasks, but deep GNNs often suffer from oversmoothing. Existing effective deep GNNs have various shortcomings including redundant complexity, oversimplified architecture, or predefined parameters. To address these issues, we propose adaptive graph diffusion networks (AGDNs), a class of compact and expressive GNNs that can effectively leverage deep neighborhood information. We introduce hopwise attention and hopwise convolution with positional embeddings for learning nodewise and channelwise hop weights, respectively, which overcomes oversmoothing and ensures a powerful ability to learn arbitrary filters in the spectral domain. Our experiments demonstrate that AGDNs can effectively learn various filters on images and exhibit superior performance on diverse and challenging open graph benchmark datasets for node classification and link prediction tasks while maintaining moderate complexity and fast running time.
Examining the Effects of Family-Implemented Literacy Interventions for School-Aged Children: A Meta-Analysis
Authors: Dahl-Leonard Katlynn , Hall Colby , Cho Eunsoo , Capin Philip , Roberts Garrett J. , Kehoe Karen F. , Haring Christa , Peacott Delanie , Demchak Alisha 
Published: January 2025

Abstract
There is considerable research evaluating the effects of family members implementing shared book reading interventions, especially during early childhood. However, less is known about the effects of family members providing instruction to help their school-aged children develop literacy skills, including both code-focused and meaning-focused skills that facilitate reading comprehension. The purpose of this meta-analysis was to describe and evaluate recent research examining the effects of at-home, family-implemented literacy interventions for school-aged children. A total of 25 interventions across 22 studies (12 with group designs and 10 with single-case experimental designs) were analyzed. The average effect on combined literacy outcomes was estimated as g = 0.36 (p < .01; Q = 191.83; I
2 = 36.17) for group design studies and g = 1.50 (p < .01; Q = 114.58; I
2 = 38.58) for single-case experimental design studies. Notably, for group design studies, effects varied by literacy outcome type. The mean effect for code-focused outcomes (i.e., PA, decoding/word reading, spelling, text reading) was g = 0.28 (p < .01) and the mean effect for meaning-focused outcomes (i.e., vocabulary, listening comprehension, reading comprehension) was g = 0.41 (p < .01). Overall, these findings support the implementation of family-delivered literacy interventions to improve literacy outcomes for school-aged children. At the same time, this meta-analysis revealed the paucity of research examining the effects of family-implemented literacy interventions, especially for older children, indicating a need for more research on this topic.