bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult neuromuscular choristoma, a rare peripheral nerve pathology: illustrative case
Authors: Ricciardelli Ashley , Flores Alex , Lu Hsiang-Chih , Guney Ekin , Perry Arie , Grochmal Joey 
Published: January 2024

BACKGROUND
Neuromuscular choristomas (NMCs) are rare tumors involving aberrant intercalation of muscle fibers into peripheral nerves, most commonly the sciatic nerve. Although benign, these lesions risk developing into NMCs with desmoid-type fibrosis (NMC-DTFs), aggressive lesions potentially requiring amputation. Currently, information on NMCs and the link between NMCs and NMC-DTFs is limited in adults, with the majority of cases reported in children. We present the case of a 66-year-old male with a sciatic NMC alongside a Preferred Reporting Items for Systematic Reviews and Meta-Analyses–based systematic review of similar cases to better characterize this lesion in the adult population.

OBSERVATIONS
A male presented with 10 years of progressive left lower-extremity weakness and paresthesia, and a mildly enlarged proximal sciatic nerve was discovered on magnetic resonance imaging. He underwent left sciatic fascicular nerve biopsy, with histopathological examination identifying the lesion as an NMC. The literature review revealed that our case, alongside other cases of adults with NMCs, shared characteristics similar to NMCs in the pediatric population.

LESSONS
More comprehensive studies of adults with NMCs are needed, as the current literature contains limited information concerning disease course, diagnostic characteristics, and treatment. Furthermore, NMCs in adults should be handled with care because of the increased likelihood of transformation to NMC-DTF after surgical intervention.
A new surgical method to treat intracanal lumbar disc herniation using the unilateral biportal endoscopic transforaminal approach: patient series
Authors: Segawa Tomohide , Iwai Hiroki , Inanami Hirohiko , Takano Yuichi , Yuzawa Yohei , Kaneko Takeshi , Taniguchi Kenta , Yanagisawa Kazuyoshi , Yokosuka Junichi , Tominaga Ryoji , Nakamoto Hideki , Sasaki Katsuyuki , Koga Hisashi 
Published: January 2024

BACKGROUND
Unilateral biportal endoscopic lumbar discectomy (UBELD) is a new minimally invasive spine surgery. The purpose of this study is to describe a new surgical method to treat intracanal lumbar disc herniation (LDH) using the unilateral biportal endoscopic transforaminal approach (UBE-TFA). The first 15 patients who had undergone UBELD for single-level LDH were included in this study. Operative time, intraoperative blood loss, postoperative stay, and intraoperative complications were recorded. The Oswestry Disability Index (ODI), numeric rating scale (NRS) score for leg pain, and modified MacNab criteria were assessed at 3 months postoperatively.

OBSERVATIONS
The mean operative time was 52.0 ± 13.8 minutes. The mean intraoperative blood loss was 10.5 ± 10.2 mL. The mean postoperative stay was 1.1 ± 0.3 days. There were no complications. The postoperative mean ODI was significantly improved from 44.9 ± 14.4 to 7.7 ± 11.2 at the final follow-up (p < 0.001). There was a significant decrease in the postoperative mean NRS score for leg pain, from 6.1 ± 1.9 to 0.8 ± 1.3 at the final follow-up (p < 0.001). Based on the modified MacNab criteria, good to excellent results were obtained in 86.7% of the patients.

LESSONS
We considered UBELD-TFA as not only one of the promising surgical methods for UBELD, but also a new surgical implementation of the TFA.
Bullying Memberikan Dampak Terhadap Motivasi Belajar Siswa Sma Negeri 3 Padang Panjang
Authors: Perdamaian Bara , Marheni Eddy , Donie Donie , Yenes Ronni 
Published: January 2024

Bullying seringkali memberikan efek yang serius terhadap peserta didik. Seperti mengucilkan diri sendiri dari dunia luar, tidak percaya diri dan merasa depresi hingga dapat juga bunuh diri. Tujuan penelitian untuk mengetahui dampak bullying terhadap motivasi belajar siswa di SMA Negeri 3 Padang Panjang. Penelitian ini merupakan jenis penelitian kualitatif. Teknik pengumpulan data berupa observasi dan wawancara, sedangkan dokumentasi berupa foto yang diambil saat melakukan wawancara. Teknik Analisis data penelitian menggunakan teknik atau model Miles yaitu, “data Reduction, data Display dan Conclusion Drawing/ Verification”. Dari hasil dari penelitian menyimpulkan bahwa bentuk bullying yang dialami subjek di sekolah ada tiga jenis bentuk bullying yaitu bullying fisik, verbal, dan psikologis. Selain itu, Faktor yang menyebabkan siswa mengalami tindakan bullying yaitu dikarenakan adanya siswa yang mempunyai fisik kecil dan lemah, siswa yang kurang percaya diri, susah menyesuaikan dengan lingkungan, dan dianggap tidak menarik di lingkungan usia remaja. Serta pelaku merasa memiliki kekuasaan dan merasa ingin diakui dikalangan mereka. Dan bullying di sekolah mempunyai dampak ke motivasi belajar yang dapat menghambat perkembangan siswa di sekolah, korban bullying merasa takut lalu menarik diri dari teman-teman di kelas nya, menjadi pasif dan merasa kurang fokus mengikuti kegiatan belajar mengajar di kelas. tak jarang juga korban merasa malas untuk datang kesekolah karena takut dengan tindakan pembullyan oleh teman mereka. Maka dari orang tua, pihak sekolah maupun guru BK perlu melakukan perhatian dan tindakan agar Bulliying yang terjadi di SMA Negeri 3 Padang Panjang tidak terjadi lagi.
Kata Kunci: Bullying, Motivasi, Belajar
Pengembangan Multimedia Pembelajaran Lari 60 Meter Menggunakan Aplikasi PPT
Authors: Dianah Dianah , Rury Rizhardi  , Kurnia Maya 
Published: January 2024

Permasalahan dalam peneliti ini adalah kurangnya pemahaman siswa MTs Tasihiliya Ogan Ilir terhadap pembelajaran lari 60 meter.Â Maka dari itu penelitian bertujuan untuk mengembangkan model lari 60 meter melalaui multimedia aplikasi PPT (power Point) pada siswa MTs Tasihliya. Jenis penelitian ini merupakan penelitian dan pengembangan. Metode yang digunakan ialah metode R&D, Teknik pengumpulan data yang digunakan ialah Validasi.
Selanjutnya produk diuji cobakan kepada siswa MTs Tasihliya melalui uji coba sekala kecil, sekala besar, dan produk akhir. Subjek uji coba produk adalah anggota siswa Mts Tasihliya.
Adapun data hasil materi dari aspek kualitas materi mendapatkan nilai 90% dengan kategori â€œsangat validâ€ dan aspek isi mendapatkan nilai 90% dengan kategori â€œsangat valid. Data validasi ahli media dari aspek tampilan mendapatkan nilai 91,8% dengan kategori â€œSangat Validâ€™dan aspek pemrograman mendapatkan nilai 90% dengan kategori â€œSangat Validâ€. Untuk uji coba lapangan aspek tampilan mendapatkan nilai â€œ91,6% dengan kategori â€œSangat Baikâ€, aspek isi mendapatkan nilai 91,8% dengan kategori â€œSangat Baikâ€ dan aspek latihan mendapatkan nilai 91,7% dengan kategori â€œSangat Baikâ€. Dapat disimpulkan bahwa produk multimedia lari 60 meter yang dikembangkan oleh peneliti layak digunakan untuk siswa MTs Tasihliya Ogan Ilir.
Archaeology and Comics
Authors: Barletta Emiliano , Lo Manto Alessio 
Published: January 2024

When considering comics, our initial association tends to be with content tailored for a younger audience. Indeed, within the general publishing industry, the predominant perception aligns comics with a children-oriented paradigm. Nevertheless, over recent decades, comics, particularly in the guise of graphic journalism, have rightfully earned their place as a tool for disseminating information and scientific knowledge. Through a unique fusion of images, artwork, narrative voices, and dialogues, the conventional comic book has transcended mere fantasy storytelling, evolving into a sophisticated form of illustrated reportage.
In the forthcoming pages, Emiliano Barletta and Alessio Lo Manto illuminate the vast potential inherent in the language of comic books for communicating scientific archaeology to an adult audience beyond the professional sphere. How might this expressive medium reshape both the perception and substance of our discipline? Can it foster a more inclusive and thus socially relevant dimension within archaeology? Perhaps, as readers of Ex Novo delve into these pages, they will sense our shared viewpoint… Enjoy the read!
Peri-lesion regions in differentiating suspicious breast calcification-only lesions specifically on contrast enhanced mammography
Authors: Cao Kun , Gao Fei , Long Rong , Zhang Fan-Dong , Huang Chen-Cui , Cao Min , Yu Yi-Zhou , Sun Ying-Shi 
Published: January 2024

PURPOSE: The explore the added value of peri-calcification regions on contrast-enhanced mammography (CEM) in the differential diagnosis of breast lesions presenting as only calcification on routine mammogram. METHODS: Patients who underwent CEM because of suspicious calcification-only lesions were included. The test set included patients between March 2017 and March 2019, while the validation set was collected between April 2019 and October 2019. The calcifications were automatically detected and grouped by a machine learning-based computer-aided system. In addition to extracting radiomic features on both low-energy (LE) and recombined (RC) images from the calcification areas, the peri-calcification regions, which is generated by extending the annotation margin radially with gradients from 1 mm to 9 mm, were attempted. Machine learning (ML) models were built to classify calcifications into malignant and benign groups. The diagnostic matrices were also evaluated by combing ML models with subjective reading. RESULTS: Models for LE (significant features: wavelet-LLL_glcm_Imc2_MLO; wavelet-HLL_firstorder_Entropy_MLO; wavelet-LHH_glcm_DifferenceVariance_CC; wavelet-HLL_glcm_SumEntropy_MLO;wavelet-HLH_glrlm_ShortRunLowGray LevelEmphasis_MLO; original_firstorder_Entropy_MLO; original_shape_Elongation_MLO) and RC (significant features: wavelet-HLH_glszm_GrayLevelNonUniformityNormalized_MLO; wavelet-LLH_firstorder_10Percentile_CC; original_firstorder_Maximum_MLO; wavelet-HHH_glcm_Autocorrelation_MLO; original_shape_Elongation_MLO; wavelet-LHL_glszm_GrayLevelNonUniformityNormalized_MLO; wavelet-LLH_firstorder_RootMeanSquared_MLO) images were set up with 7 features. Areas under the curve (AUCs) of RC models are significantly better than those of LE models with compact and expanded boundary (RC v.s. LE, compact: 0.81 v.s. 0.73, p < 0.05; expanded: 0.89 v.s. 0.81, p < 0.05) and RC models with 3 mm boundary extension yielded the best performance compared to those with other sizes (AUC = 0.89). Combining with radiologists’ reading, the 3mm-boundary RC model achieved a sensitivity of 0.871 and negative predictive value of 0.937 with similar accuracy of 0.843 in predicting malignancy. CONCLUSIONS: The machine learning model integrating intra- and peri-calcification regions on CEM has the potential to aid radiologists’ performance in predicting malignancy of suspicious breast calcifications.
Application of a nonparametric technique for testing the hypothesis of independence of random variables in conditions of a large volume of statistical data
Authors: Lapko A. V. , Lapko V. A. , Bakhtina A. V. 
Published: January 2024

The problem of testing the hypothesis about the independence of random variables in conditions of large volumes of statistical data is considered. The results of solving the problem are necessary when estimating probability densities of random variables and synthesizing information processing algorithms. A nonparametric technique is proposed for testing the hypothesis about the independence of random variables in a sample containing a large amount of statistical data. The technique is based on compression of the initial statistical information by decomposition of the range of values of random variables. The generated data array consists of the centers of sampling intervals and the corresponding frequencies of observations from the original sample. The information obtained is used in the construction of a nonparametric pattern recognition algorithm corresponding to the maximum likelihood criterion. The evaluation of the distribution laws in classes is carried out under the assumption of independence and dependence of the compared random variables. When restoring the laws of distribution of random variables in classes, regression estimates of probability densities are used. Under these conditions, estimates of the probabilities of pattern recognition errors in classes are calculated. According to their minimum value, a decision is made on the independence or dependence of random variables. The technique was applied in the analysis of remote sensing data of forest areas, linear and nonlinear dependencies between pairs of spectral characteristics of the objects of study were determined.Keywords:
State primary special standard of the unit of heat quantity in the fi eld of solution and reaction calorimetry GET 133-2023
Authors: Mishina K. A. , Korchagina E. N. , Kazartsev Ia. V. 
Published: January 2024

The article shows the need to develop methods and tools for realization and transferring a unit of heat quantity in the fi eld of measuring small thermal effects of physical and chemical interactions by the method of isothermal titration calorimetry. The relevance of the work is due to the wide application of measuring instruments implementing this method and the lack of standardized metrological procedures and tools. To solve the problem of ensuring unity and traceability of measurements in this fi eld, VNIIM calorimetry laboratory conducted research to expand the functional and measuring capabilities of the State primary special standard of the unit of heat quantity in the fi eld of solution and reaction calorimetry GET 133-2012. In the course of work a reference titration microcalorimeter MKT was developed, investigated, and included in the GET 133-2012. Microcalorimeter MKT was designed to realize, store, and transfer a unit of heat quantity in the fi eld of measuring small thermal effects in liquid media. As a result of microcalorimeter studies, the capability of realizing and transferring a unit of heat quantity in a new range was confi rmed: from 100 to 5000 μJ with an expanded uncertainty from 1.2 to 8.6 %. The improved GET 133-2012 with an updated composition and new metrological characteristics was approved as the State primary special standard of the unit of heat quantity in the fi eld of solution and reaction calorimetry GET 133-2023. This lays the foundations for the creation of new metrological tools and procedures for transferring the unit of heat quantity in the fi eld of solution and reaction calorimetry.
Expanding the dynamic range of a measuring system that implements the phase triangulation method
Authors: Dvoynishnikov S. V. , Bakakin G. V. , Zuev V. O. , Kashkarova M. V. , Pavlov V. A. 
Published: January 2024

The article is devoted to the development of phase triangulation and structured illumination methods for measuring the geometry of objects with arbitrary light-scattering surface properties. A method for expanding the dynamic range of a measuring system that implements the phase triangulation method is proposed. The method is based on automatic adjustment of the exposure time of the photodetector, excessive collection of experimental data, and complex regression analysis. The results of experimental studies of the effectiveness of the proposed method for expanding the dynamic range of the measuring system are presented. It is shown that the classical approach to image interpretation using a photodetector with a fi xed exposure duration almost always leads to a high level of error over the entire range of light-scattering properties of the surface. For low exposure values, there is an increase in the measurement error in the region of the dark surface, since the signal level there turns out to be signifi cantly weaker than for the bright regions of the measured surface. For large exposure values, an increase in the error is observed when measuring the bright area of the measured surface, since the signal is outside the dynamic range of the photodetector. The proposed method of image interpretation with an extended range of the measuring system demonstrates an error level less than or comparable to the results of image interpretation with a fi xed exposure for all measured light-scattering properties of the surface. The proposed method makes it possible to perform automated measurements without additional optimization of the photodetector parameters for the light-scattering properties of the surface of the measured object.
The Vertical Transfer Pipeline and Its Leaks: Tracking Students From Associate’s Programs to Bachelor’s Degrees
Authors: Gentsch Kerstin , Oka Yoshiko , Truelsch Sarah , Logue Alexandra 
Published: January 2024

This longitudinal study of 17,455 students, the majority from underrepresented groups, investigated leaks in the vertical transfer pipeline from associate’s-degree program entry to bachelor’s-degree receipt. Investigated were both the size of the leaks and some associated variables. Pipeline progress examinations included quantification of early persistence, plus application to, enrollment and persistence in, and graduation from, bachelor’s programs. The examined associated variables included student demographic characteristics and possible pipeline leak malleable factors: academic preparation and performance and financial need. Overall, only 23% of the original cohort received a bachelor’s degree after eight years. In addition, this study is the first to identify and quantify the transfer melt leakage point (students accepted for vertical transfer who do not enroll in bachelor’s programs), and the first to have quantified transfer shock (a transfer-related decrease in GPA) in a large general cohort (shown by 16 percentage points of the cohort). Variables involving quicker degree progress (e.g., being exempt from remediation and enrolling full-time) were negatively associated with pipeline leaks. Together the results provide guidance for policymakers and practitioners regarding how to increase vertical transfer pipeline output and increase bachelor’s degrees by community college students, particularly those from underrepresented groups, thus increasing higher education equity.
Nanopore sequencing of infectious fluid is a promising supplement for gold-standard culture in real-world clinical scenario
Authors: Zhao Manna , Zhang Yongyang , Chen Li , Yan Xuebing , Xu Tianmin , Fu Maoying , Han Yangguang , Zhang Ying , Zhang Bin , Cao Juan , Lin Jing , Shen Dan , Li Shuo , Zhu Chuanlong , Zhao Weifeng 
Published: January 2024

IntroductionInfectious diseases are major causes of morbidity and mortality worldwide, necessitating the rapid identification and accurate diagnosis of pathogens. While unbiased metagenomic next-generation sequencing (mNGS) has been extensively utilized in clinical pathogen identification and scientific microbiome detection, there is limited research about the application of nanopore platform-based mNGS in the diagnostic performance of various infectious fluid samples.MethodsIn this study, we collected 297 suspected infectious fluids from 10 clinical centers and detected them with conventional microbiology culture and nanopore platform–based mNGS. The objective was to assess detective and diagnostic performance of nanopore-sequencing technology (NST) in real-world scenarios.ResultsCombined with gold-standard culture and clinical adjudication, nanopore sequencing demonstrated nearly 100% positive predictive agreements in microbial-colonized sites, such as the respiratory and urinary tracts. For samples collected from initially sterile body sites, the detected microorganisms were highly suspected pathogens, and the negative predictive agreements were relatively higher than those in the microbial-colonized sites, particularly with 100% in abscess and 95.7% in cerebrospinal fluid. Furthermore, consistent performance was also observed in the identification of antimicrobial resistance genes and drug susceptibility testing of pathogenic strains of Escherichia coli, Staphylococcus aureus, and Acinetobacter baumannii.DiscussionRapid NST is a promising clinical tool to supplement gold-standard culture, and it has the potential improve patient prognosis and facilitate clinical treatment of infectious diseases.
Challenges and opportunities in mobile e-coaching
Authors: van 't Klooster Jan-Willem J. R. , Rabago Mayer Lucia M. , Klaassen Bart , Kelders Saskia M. 
Published: January 2024

BackgroundMobile e-health technologies have proven to provide tailored assessment, intervention, and coaching capabilities for various usage scenarios. Thanks to their spread and adoption, smartphones are one of the most important carriers for such applications.ProblemHowever, the process of design, realization, evaluation, and implementation of these e-health solutions is wicked and challenging, requiring multiple stakeholders and expertise.MethodHere, we present a tailorable intervention and interaction e-health solution that allows rapid prototyping, development, and evaluation of e-health interventions at scale. This platform allows researchers and clinicians to develop ecological momentary assessment, just-in-time adaptive interventions, ecological momentary intervention, cohort studies, and e-coaching and personalized interventions quickly, with no-code, and in a scalable way.ResultThe Twente Intervention and Interaction Instrument (TIIM) has been used by over 320 researchers in the last decade. We present the ecosystem and synthesize the main scientific output from clinical and research studies in different fields.DiscussionThe importance of mobile e-coaching for prediction, management, and prevention of adverse health outcomes is increasing. A profound e-health development strategyand strategic, technical, and operational investments are needed to prototype, develop, implement, and evaluate e-health solutions. TIIM ecosystem has proven to support these processes. This paper ends with the main research opportunities in mobile coaching, including intervention mechanisms, fine-grained monitoring, and inclusion of objective biomarker data.
RETRACTED: Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model
Authors: Alajoleen Razan M. , Oakland David N. , Estaleen Rana , Shakeri Aida , Lu Ran , Appiah Michael , Sun Sha , Neumann Jonathan , Kawauchi Shimako , Cecere Thomas E. , McMillan Ryan P. , Reilly Christopher M. , Luo Xin M. 
Published: January 2024

IntroductionLeaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus through bacterial flagellin-mediated activation of toll-like receptor 5 (TLR5).MethodsWe created MRL/lpr mice with global Tlr5 deletion through CRISPR/Cas9 and investigated lupus-like disease in these mice.ResultContrary to our hypothesis that the deletion of Tlr5 would attenuate lupus, our results showed exacerbation of lupus with Tlr5 deficiency in female MRL/lpr mice. Remarkably higher levels of proteinuria were observed in Tlr5-/- MRL/lpr mice suggesting aggravated glomerulonephritis. Histopathological analysis confirmed this result, and Tlr5 deletion significantly increased the deposition of IgG and complement C3 in the glomeruli. In addition, Tlr5 deficiency significantly increased renal infiltration of Th17 and activated cDC1 cells. Splenomegaly and lymphadenopathy were also aggravated in Tlr5-/- MRL/lpr mice suggesting impact on lymphoproliferation. In the spleen, significant decreased frequencies of regulatory lymphocytes and increased germinal centers were observed with Tlr5 deletion. Notably, Tlr5 deficiency did not change host metabolism or the existing leaky gut; however, it significantly reshaped the fecal microbiota.ConclusionGlobal deletion of Tlr5 exacerbates lupus-like disease in MRL/lpr mice. Future studies will elucidate the underlying mechanisms by which Tlr5 deficiency modulates host-microbiota interactions to exacerbate lupus.