bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing Earth‐Abundant Lead‐Free Halide Perovskite for Resistive Switching Memory and Neuromorphic Computing
Authors: Feng Zijian , Kim Jiyun , Min Jie , Guan Peiyuan , Zhang Shuo , Guan Xinwei , Mei Tingting , Huang Tianxu , Lin Chun‐Ho , Hu Long , Chen Fandi , Li Zhi , Yi Jiabao , Wu Tom , Chu Dewei 
Published: February 2025

AbstractNon‐volatile memories are expected to revolutionize a wide range of information technologies, but their manufacturing cost is one of the top concerns researchers must address. This study presents a 1D lead‐free halide perovskite K2CuBr3, as a novel material candidate for the resistive switching (RS) devices, which features only earth‐abundant elements, K, Cu, and Br. To the knowledge, this material is the first low‐dimensional halide perovskite with exceptionally low production costs and minimal environmental impact. Owing to the unique 1D carrier transport along the Cu─Br networks, the K2CuBr3 RS device exhibits excellent bipolar switching behavior, with an On/Off window of 105 and a retention time of over 1000 s. The K2CuBr3 RS devices can also act as artificial synapses to transmit various forms of synaptic plasticities, and their integration into a perceptron artificial neural network can deliver a high algorithm accuracy of 93% for image recognition. Overall, this study underscores the promising attributes of K2CuBr3 for the future development of memory storage and neuromorphic computing, leveraging its distinct material properties and economic benefits.
Tunable Ferroelectric Polarization in BaTiO3 Coupled with Zn0.5Cd0.5S Quantum Dots for Efficient Solar‐Driven Hydrogen Evolution
Authors: Pan Changyuan , Huang Kaige , Zhi Zhenhua , Yang Ying , Zhang Huimin , Xie Yufang , Zhang Chenglin , Liu Yuan , Chen Mingming , Wang Zhijie , Jiang Zhifeng , Cao Dawei 
Published: February 2025

AbstractIntegrating ferroelectric materials with semiconductor photocatalysts offers a groundbreaking strategy to enhance solar‐driven hydrogen production by improving charge separation and transfer efficiency. Herein, a synergistic system is developed by coupling the tunable ferroelectric polarization of BaTiO3 (BTO) with a Z‐scheme heterojunction in Zn0.5Cd0.5S quantum dots (ZCS QDs). The strong and adjustable built‐in electric field generated by BTO effectively drives carrier separation, enhances interfacial band bending, and mitigates the excitonic effects commonly observed in QDs, facilitating directional charge transfer. Mechanistic insights, validated by in situ X‐ray photoelectron spectroscopy (XPS) and Kelvin Probe Force Microscopy (KPFM), highlight the pivotal role of ferroelectric polarization in modulating carrier dynamics and interfacial interactions. These attributes, resulting from the synergistic effects of ferroelectric polarization and the Z‐scheme heterojunction, enable the ZCS QDs/BTO composite to achieve an outstanding hydrogen evolution rate of 0.83 mmol g−1 h−1, surpassing pure BTO and ZCS QDs by factors of 20.8 and 1.7, respectively. Notably, external polarization further amplifies hydrogen production to 1.19 mmol g−1 h−1, representing a remarkable 143% increase compared to the pristine system and showcasing the pivotal role of polarization‐enhanced built‐in electric fields in photocatalysis. This work presents a novel pathway for designing advanced photocatalysts, providing promising prospects for sustainable hydrogen production.
Reduction in adsorbent granule dimensionality to strengthen lithium adsorption in low‐grade salt lakes
Authors: Chen Jun , Yu Jianguo , Lin Sen 
Published: February 2025

AbstractSluggish internal mass transfer within granulated adsorbents constrains the efficiency of Li+ extraction from low‐grade salt lakes. In this study, Li+ diffusion behavior simulations using finite element analysis indicated that reducing the granule dimensionality enhanced Li+ transfer in aluminum‐based lithium adsorbents, with ionic strength as the driving force. Hence, low‐dimensional aluminum‐based adsorbent granules (LD‐LDHs) with fast transport channels and highly accessible adsorption sites were directionally prepared via a wet‐spinning method. Adsorption kinetics suggested LD‐LDHs with reduced internal diffusion resistance achieved equilibrium in less than 30 min, which was significantly shorter than the 36 h required for larger granules prepared by conventional extrusion molding, while maintaining the performance of the encapsulated active components. During continuous lithium extraction from low‐grade Qarhan old brine, LD‐LDHs reached adsorption saturation in 60 min, with a 1.8‐fold increased working capacity, and the desorption solution was of higher quality, favorable for subsequent lithium carbonate production processes.
Physical activity may protect myelin via modulation of high‐density lipoprotein
Authors: Boa Sorte Silva Nárlon C. , Balbim Guilherme M. , Stein Ryan G. , Gu Yi , Tam Roger C. , Dao Elizabeth , Alkeridy Walid , Lam Kevin , Kramer Arthur F. , Liu‐Ambrose Teresa 
Published: February 2025

AbstractINTRODUCTIONPhysical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied.METHODSWe assessed cross‐sectionally whether serum high‐density lipoprotein (HDL), low‐density lipoprotein, and triglycerides moderated the association between physical activity and in vivo myelin in older individuals with CSVD and mild cognitive impairment.RESULTSWe included 81 highly educated, community‐dwelling older individuals (mean age 74.57 years), 64% of whom were female. Regression models revealed that HDL levels significantly moderated the relationship between physical activity and myelin in the sagittal stratum, wherein higher physical activity levels were linked to greater myelin levels for those with average or high HDL (standardized B [95% CI] = 0.289 [0.087 to 0.491], p = 0.006).DISCUSSIONPhysical activity may promote myelin health partly through HDL. Data from longitudinal studies are needed to confirm our findings.Highlights
Myelin loss is common in individuals with cerebral small vessel disease (CSVD).
Physical activity was positively associated with myelin in older adults with CSVD.
High‐density lipoproteins (HDL) levels were also positively related to myelin.
Physical activity effects on myelin were moderated by HDL levels.
Evaluation of two plasma‐based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies
Authors: Dittrich Anna , Blennow Kaj , Tan Kübra , Benedet Andrea L. , Skoog Ingmar , Höglund Kina , Ashton Nicholas J. , Zetterberg Henrik , Kern Silke 
Published: February 2025

AbstractINTRODUCTIONApolipoprotein E (APOE) ε4 allele status is associated with an increased risk of Alzheimer's disease and should be determined prior to initiation of anti‐amyloid beta antibody treatment, because of increased risk of treatment‐related side effects. Plasma‐based apoE4 proteotyping may be an alternative to genotyping, with limited clinical evidence.METHODSapoE4 proteotyping was performed on 164 memory‐clinic patients, using one chemiluminescent enzyme immunoassay (CLEIA) and one nucleic acid–linked immunosandwich assay (NULISA). The assays were evaluated against APOE ε4 blood genotyping.RESULTSThe CLEIA had a 100% sensitivity and 98.5% specificity to classify APOE ε4 homozygosity and carriership in relation to genotyping. The NULISA had a 92.9% sensitivity and 97.1% specificity to classify homozygosity and a 100% sensitivity and 98.5% specificity to classify carriership.DISCUSSIONThe high performance suggests that the assays may be used as an easily available tool for identifying individuals for definitive APOE ε4 genotyping in a two‐step approach.Highlights
Plasma‐based proteotyping presented good to excellent sensitivity in identifying apolipoprotein E (APOE) ε4 homozygosity.
The negative predictive value was also very good to excellent, allowing us to rule out APOE ε4 homozygosity with high precision.
Assays with excellent precision show potential for identifying individuals for definitive APOE ε4 genotyping in a two‐step approach.
Characterizing the olfaction and dementia association in the community‐based ARIC study
Authors: Shrestha Srishti , Zhu Xiaoqian , Kucharska‐Newton Anna M. , Yuan Yaqun , Kamath Vidyulata , Palta Priya , Deal Jennifer A. , Mosley Thomas H. , Griswold Michael E. , Chen Honglei 
Published: February 2025

AbstractINTRODUCTIONFew studies have characterized the association of olfaction with dementia in detail across diverse sociodemographic subgroups.METHODSWe examined the association of one‐time‐point olfactory status with incident dementia overall and by age, race, sex, and apolipoprotein E (APOE) ε4 status (n = 4470, mean age: 75 ± 5 years, 21% Black), and 5‐year olfactory change with incident dementia (n = 2658) in the community‐based Atherosclerosis Risk in Communities (ARIC) study.RESULTSCompared to good olfaction, moderate olfaction (hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 1.26 to 1.86), hyposmia (HR: 2.24, 95% CI: 1.81 to 2.78), and anosmia (HR: 3.47, 95% CI: 2.77 to 4.34) were all associated with higher dementia hazard; these associations were consistent across age, race, sex, and APOE ε4 groups. The absolute risk difference between anosmia and good olfaction was higher in APOE ε4 carriers than in non‐carriers. Those with stable anosmia and converting from normal olfaction to anosmia over time showed particularly strong associations.DISCUSSIONOlfactory impairment was robustly associated with incident dementia, with strongest associations in those with persistent impairment and greater olfactory decline over ∼5 years.Highlights
We examined olfactory status and olfactory change in relation to incident dementia.
Poor olfactory status was robustly associated with higher dementia rate.
Associations were robust across subgroups of age, sex, race, and APOE ε4 status.
Persistent poor olfaction or decline over time showed the strongest associations.
Adsorption of Cu2+ From Water Onto PVDF Electrospinning Membrane Functionalized γ‐Al2O3 Nanoparticles
Authors: He Fengli , Zhang Haihong , Zhang Long , Zhu Linlin , Yuan Jinyi , Yu Fangli 
Published: February 2025

ABSTRACTIn recent years, heavy metal ion pollution issues occur frequently, and the prevention and control of heavy metal pollution have become an urgent environmental problem for human beings. To reduce the harm caused by heavy metal ion pollution, γ‐Al2O3/polyvinylidene fluoride (γ‐Al2O3/PVDF) composite membranes were prepared by electrospinning technology. The microstructures, phase structures, mechanical properties, and adsorption properties of the composite membrane were characterized by SEM, XRD, universal testing machine, and spectrophotometer. The results showed that the γ‐Al2O3/PVDF composite fibers were randomly deposited, and the diameter of the fibers varied from 1.65 to 2.35 μm. The three‐dimensional network structures were formed and the porosity was as high as 85.28%. When the content of γ‐Al2O3 was 4%, the tensile strength of γ‐Al2O3/PVDF composite membrane was the highest, which was 11.33 MPa. When the content of γ‐Al2O3 was 6%, the adsorption capacity of γ‐Al2O3/PVDF composite membrane on Cu2+ was the maximum. After adsorption, the adsorption capacity was 152.65 mg/g. The pseudo‐second‐order adsorption kinetics equation was suitable for describing the adsorption process; it meant that the adsorption process might be a chemical adsorption. These findings suggest that the γ‐Al2O3/PVDF composite membranes have great potential in the application of water treatment.
Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐sectional Results from a Large Community‐based Cohort
Authors: Yates Katherine A. , Alvarez Carolina , Schwartz Todd A. , Savage‐Guin Serena , Renner Jordan B. , Bakewell Catherine J. , Kohler Minna J. , Lin Janice , Samuels Jonathan , Walker Tessa , Golightly Yvonne M. , Nelson Amanda E. 
Published: February 2025

ObjectivesTo determine 1) associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient‐reported symptoms, and 2) diagnostic accuracy of US definitions for rKOA, in a community‐based cohort.MethodsParticipants enrolled in the Johnston County Health Study (JoCoHS, 2019‐24, n=902) provided demographics, comorbidities, clinical features and symptoms, along with imaging with standardized acquisition and scoring protocols. Logistic regression models provided odds ratios adjusted for age, sex, race, ethnicity, body mass index (BMI), education level, comorbidities, and knee injury for associations among US features and KOA outcomes. Diagnostic accuracy was assessed using standard metrics with rKOA as the gold standard.ResultsComplete imaging data were available for 861 participants (1711 knees), 34% men, 25% Black, 10% Hispanic, mean age 55 years and mean BMI 33 kg/m2. Half of knees were symptomatic, 1/3 had rKOA, and 1 in 5 had symptomatic rKOA. US‐identified osteophytes, effusion, meniscal extrusion, cartilage damage, calcium crystals, and popliteal cysts were associated with KOA outcomes. A US definition including both mild osteophytes and mild cartilage damage gave an area under the receiver operating characteristic curve (AUC) of 0.76 for diagnosing rKOA (validated in an external cohort).ConclusionsWe identified common US features in participants with and without KOA, along with significant associations between US features and rKOA, symptomatic rKOA, and symptoms. US‐based diagnosis of rKOA shows promise for general use. US is a valuable and accessible modality for assessment of knee OA features in clinical and research settings, including those with limited resources.image
Greening the Path to Family Firm Innovation: Empirical Evidence From the Spanish Manufacturing Industry
Authors: Martínez‐Alonso Rubén , Martínez‐Romero María J. , Rojo‐Ramírez Alfonso A. 
Published: February 2025

ABSTRACTAre environmentally focused family firms really better innovators? This paper addresses this intriguing question and bridges the existing gap on the link between environmental investment and innovation within family firms, considering the mediating role of collaboration breadth, and the moderating influence of family management. Applying a moderated mediation analysis to an unbalanced panel dataset of 4836 observations of Spanish family firms, the results show that environmental investment has a positive impact on innovation. Collaboration breadth fully mediates the relationship between environmental investment and innovation. Moreover, family management strengthens this mediating relationship. That is, the adoption of technological collaboration is more likely to occur in environmentally focused family firms when there is a higher number of family members in the firm's TMT, ultimately leading to improved innovation outcomes. This study contributes to understanding how family firm dynamics influence sustainability‐driven innovation, offering valuable insights for future research in this evolving field.
National Identity and Economic Inequality: New Insights From Disadvantaged and Advantaged Groups
Authors: De Cristofaro Valeria , Cervone Carmen , Filippi Silvia , Marinucci Marco , Scatolon Andrea , Valtorta Roberta Rosa , Vezzoli Michela , Pellegrini Valerio 
Published: February 2025

ABSTRACTThis research examined the association of national identity with system justification and collective action against economic inequality specifically relating to socioeconomic status (Study 1), ethnicity (Study 2) and gender (Study 3) among both disadvantaged and advantaged groups. Additionally, in Study 3, we investigated the competing predictive role of national narcissism. Across all studies (N = 3387) and regardless of group membership, we consistently found that participants who scored higher on national identity showed stronger system justification and, in turn, lower joint collective action intentions. After controlling for national narcissism in Study 3, however, the relation of national identity with joint collective action through system justification became non‐significant. Instead, national narcissism was positively related to system justification and then negatively associated with joint collective action after controlling for national identity. These results advance the understanding of the psychosocial pathways that undermine collective efforts towards social change, thereby contributing to the maintenance of economic inequality.
The association of physical activity with survival in colon cancer versus a matched general population: Data from Cancer and Leukemia Group B 89803 and 80702 (Alliance)
Authors: Brown Justin C. , Ma Chao , Shi Qian , Saltz Leonard B. , Shields Anthony F. , Meyerhardt Jeffrey A. 
Published: February 2025

AbstractBackgroundColon cancer patients have inferior overall survival than a matched general population (MGP). It is unknown if physical activity is associated with a reduction in this survival disparity.MethodsData were analyzed from two National Cancer Institute–sponsored postoperative treatment trials in stage III colon cancer, Cancer and Leukemia Group B (CALGB) 89803 and 80702, with 2876 patients who self‐reported physical activity. Physical activity was converted to metabolic equivalents (MET‐hours/week). The MGP was derived from the National Center for Health Statistics and matched on age, sex, and year.ResultsIn CALGB 89803, among patients who were alive at 3 years, those with <3.0 and ≥18.0 MET‐hours/week had subsequent 3‐year overall survival rates that were −17.1% (95% confidence interval [CI], −22.4 to −11.8) and −3.5% (95% CI, −7.7 to 0.3) lower than MGP, respectively. In CALGB 80702, among patients who were alive at 3 years, those with <3.0 and ≥18.0 MET‐hours/week had subsequent 3‐year overall survival rates that were −10.8% (95% CI, −15.4 to −6.9) and −4.4% (95% CI, −7.6 to −1.6) lower than MGP, respectively. In pooled analyses, among patients who were alive and did not have tumor recurrence by year 3 (n = 1908), those with <3.0 and ≥18.0 MET‐hours/week had subsequent 3‐year overall survival rates that were −3.1% (95% CI, −6.2 to −0.3) lower and 2.9% (95% CI, 1.5–4.2) higher than MGP, respectively.ConclusionsPhysical activity is associated with an attenuation of the survival disparity between patients with stage III colon cancer participating in clinical trials and MGP. Colon cancer survivors who are physically active may achieve survival that approximates the MGP.
InterobServer AgreeMent in Pd‐l1 evaLuatIoN on cytoloGical samples—SAMPLING project: A multi‐institutional, international study
Authors: Acanfora Gennaro , Iaccarino Antonino , Cerbelli Bruna , Di Cristofano Claudio , Bellevicine Claudio , Barberis Massimo , Bonoldi Emanuela , Bubendorf Lukas , Calaminus Andreas , Campione Severo , Canberk Sule , Cavazza Alberto , Cazzaniga Giorgio , Chijioke Obinna , Clery Eduardo , Eccher Albino , Engels Marianne , Fiorentino Vincenzo , Graziano Paolo , Kern Izidor , Kholova Ivana , Laatta Jari , Labiano Tania , Leopizzi Martina , Lozano Maria D. , Luis Rita , Maffei Elisabetta , Marando Alessandro , Martini Maurizio , Merenda Elisabetta , Montella Marco , Morales Allan Argueta , Nishino Michiya , Pagni Fabio , Hofman Paul , Pernazza Angelina , Roy‐Chowdhuri Sinchita , Saieg Mauro , Savic Prince Spasenija , Siddiqui Momin T. , Stoos‐Veic Tajana , Strojan Fležar Margareta , Sundov Dinka , VanderLaan Paul , Vrdoljak‐Mozetič Danijela , Zeppa Pio , Troncone Giancarlo , Vigliar Elena 
Published: February 2025

AbstractIntroductionThe aim of this project is to assess interobserver agreement for programmed death‐ligand 1 (PD‐L1) scoring on of non–small cell lung cancer (NSCLC) on cytological specimens in a large‐scale multicenter study, by exploiting the cell block‐derived tissue microarray (cbTMA) approach.MethodsA total of 65 cell blocks (CB) diagnosed as NSCLC were retrospectively collected and selected for TMA preparation. Hematoxylin–eosin and PD‐L1 stained slides were digitized and uploaded on a free web sharing platform. Participants were asked to provide PD‐L1 assessment by using the clinically relevant cutoff of tumor proportion score (TPS) (<1%; 1%–49%; >50%). Interobserver agreement was calculated using Fleiss’s κ.ResultsOf 65 CBs, 11 were deemed not suitable; therefore, an overall number of 54 cores were used for the preparation of four TMAs. A total of 1674 evaluations were provided by 31 cytopathologists from 21 different institutions in nine countries. The statistical analysis showed a moderate overall agreement (κ = 0.49). The highest agreement was achieved in the TPS >50% category (κ = 0.57); moderate agreement was observed in TPS <1% category (κ = 0.51) and the lowest κ value was obtained for TPS 1%–49% category (k = 0.32).ConclusionsThe overall moderate agreement observed showed that there is still room for improvement in inter‐pathologist agreement for PD‐L1 evaluation on cytological samples, highlighting the need for standardization in sample preparation, focused training in PD‐L1 evaluation on cytological material, and the integration of machine learning tools to improve interobserver consistency.
In heart failure, echocardiographic parameters of right ventricular function are powerful tools to predict renal failure
Authors: Reinecke Alexander , Dißmann Paulina , Frey Norbert , Müller Oliver J. , Seoudy Hatim , Frank Johanne , Frank Derk , Spehlmann Martina E. 
Published: February 2025

AbstractBackgroundChronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated with prolonged hospitalization, increased need for intensive care and mortality. There is an urgent need to identify factors that influence the interaction between heart and kidney disorders, often described as cardiorenal syndrome (CRS). We investigated the epidemiology and risk factors of renal insufficiency in patients with HF.MethodsWe conducted a retrospective cohort study including 281 consecutive patients with HF that are examined at regular intervals at our outpatient clinic for HF. CKD was defined as the presence of an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 and worsening renal function (WRF) was defined as a decrease of eGFR > 15% within a year. We assessed the patient's medical history, laboratory and echocardiographic parameters at baseline and after 12 months.ResultsRight ventricular dysfunction was associated with CKD and WRF. In particular, echocardiographic parameters ‘tricuspid annular plane systolic excursion (TAPSE) < 15 mm’ (P < 0.001; OR 2.932), ‘tricuspid regurgitation (TR) > I°’ [P < 0.001; odds ratio (OR) 5.958] and dilatation of inferior vena cava (IVC) (P < 0.001; OR 3.670) were significantly correlated with renal failure. N‐terminal pro‐B‐type natriuretic peptide levels were significantly associated with CKD (P < 0.001; OR 6.109) and correlated with pressure and volume load of the right heart.ConclusionsThe results of this work support the theory of right‐sided cardiac backward failure, often accompanied by hypervolaemia, as a leading cause of HF‐related renal failure. Right heart parameters, especially TR, TAPSE and IVC, are obtained easily by transthoracic echocardiography and can predict renal failure.