bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migrants vénézuéliens en Équateur : confronter la criminalisation symbolique par l’espace
Authors: Vargas Aguirre Martha , Yapud Ibadango Guadalupe 
Published: December 2023

En 2018, le gouvernement équatorien a fait face à un afflux massif de Vénézuéliens fuyant la crise humanitaire et politique dans leur pays. Dans cet article, nous examinons la politique migratoire déployée entre 2018 et 2019 par le gouvernement équatorien pour réguler ces arrivées. Pour ce faire, nous développons une articulation théorico-analytique restreinte ; nous mobilisons la perspective foucaldienne des études critiques des politiques publiques (Foucauldian Critical Policy Studies), à travers l’utilisation du concept foucaldien de problématisation et nous l’articulons à la production sociale de l’espace dans le cadre de la géographie critique. Ainsi, grâce à l’analyse des documents de politique publique, nous concluons que le gouvernement équatorien criminalise symboliquement la population vénézuélienne en la problématisant comme dangereuse et potentiellement criminelle. En revanche, les entretiens avec les immigrés vénézuéliens montrent que la population migrante répond et résiste à cette problématisation par le biais de stratégies sociospatiales. De cette manière, cette analyse cherche à contribuer aux rares études sur la criminologie de la mobilité dans le Sud global.
Research on the control strategies of data flow transmission paths for MPTCP-based communication networks
Authors: Shu Zhong , Du Hua-Bing , Zhu Xin-Yu , Ruan Shi-Xin , Li Xian-Ran 
Published: December 2023

The performance of multipath transmission control protocol (MPTCP) subflow through the enhancement mechanism of the MPTCP communication is improved. When dealing with multiple MPTCP subflows occupying the same transmission path, critical issues such as selection and optimization of multipath, and efficient scheduling of available multiple tracks are effectively addressed by incorporating the technology called software defined network (SDN) that is constructed based on four key parameters, namely, network transmission bandwidth, transmission paths, path capacity, and network latency. Besides, critical equipment such as the network physical device layer and SDN controller are integrated with the four parameters. So, the network model defines the transmission control process and data information. Considering the predetermined total network bandwidth capacity to select multiple paths, the adequate bandwidth capacity is determined by defining the data transfer rate between MPTCP terminals and MPTCP servers. However, the processing latency of the OpenFlow switch and the SDN controller is excluded. The effective network transmission paths are calculated through two rounds of path selection algorithms. Moreover, according to the demand capacity of the data transmission and the supply capacity of the required occupied network resource, a supply and demand strategy is formulated by considering the bandwidth capacity of the total network and invalid network latency factors. Then, the available network transmission path from the valid network transmission path is calculated. The shortest path calculation problem, which is the calculation and sorting of the shortest path, is transformed into a clustering, Inter-Cluster Average Classification (ICA), problem. The instruction of the OpenFlow communication flow is designed to schedule MPTCP subflows. Thus, various validation objectives, including the network model, effective network latency, effective transmission paths, supply-demand strategies, ineffective transmission paths, shortest feasible paths, and communication rules are addressed by the proposed method whose reliability, stability, and data transmission performance are validated through comparative analysis with other conventional algorithms. Found that the network latency is around 20 s, the network transmission rate is approximately 10 Mbps, the network bandwidth capacity reaches around 25Mbps, the network resource utilization rate is about 75%, and the network swallowing volume is approximately 3 M/s.
Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa
Authors: Ben Abdallah Hakim , Bregnhøj Anne , Emmanuel Thomas , Ghatnekar Gautam , Johansen Claus , Iversen Lars 
Published: December 2023

ImportanceHidradenitis suppurativa is a painful immune-mediated disorder with limited treatment options; hence, a need exists for new treatments.ObjectiveTo evaluate the feasibility of heat shock protein 90 inhibition by RGRN-305 as a novel mechanism of action in treating moderate to severe hidradenitis suppurativa.Design, Setting, and ParticipantsThis was a parallel-design, double-blind, proof-of-concept, placebo-controlled randomized clinical trial conducted between September 22, 2021, and August 29, 2022, at the Department of Dermatology, Aarhus University Hospital in Denmark. The study included a 1- to 30-day screening period, a 16-week treatment period, and a 4-week follow-up period. Eligibility criteria included age 18 years or older and moderate to severe hidradenitis suppurativa with 6 or more inflammatory nodules or abscesses in at least 2 distinct anatomic regions. Of 19 patients screened, 15 patients were enrolled in the study. Intention-to-treat analysis was performed.InterventionsPatients were randomly assigned (2:1) to receive oral RGRN-305, 250-mg tablet, or matching placebo once daily for 16 weeks.Main Outcomes and MeasuresThe primary efficacy end point was the percentage of patients achieving Hidradenitis Suppurativa Clinical Response 50 (HiSCR-50) at week 16. Secondary efficacy end points included HiSCR-75 or HiSCR-90, Hidradenitis Suppurativa Physician’s Global Assessment, Dermatology Life Quality Index scores, and a pain numeric rating scale. Safety was assessed by adverse events, physical examinations, clinical laboratory measurements, and electrocardiograms.ResultsA total of 15 patients were enrolled, completed the study, and were included in all analyses (10 [67%] female; median age, 29 [IQR, 23-41] years). The primary end point HiSCR-50 at week 16 was achieved by a higher percentage in the RGRN-305 group (60% [6 of 10]) than in the placebo group (20% [1 of 5]). Improvements were also observed across all secondary end points at week 16, including higher rates of the harder-to-reach HiSCR levels; 50% (5 of 10) achieved HiSCR-75 and 30% (3 of 10) achieved HiSCR-90, whereas none of the placebo-treated patients achieved HiSCR-75 or HiSCR-90. RGRN-305 was well tolerated, with no deaths or serious adverse events, and treatment-emergent adverse events were similarly frequent between the RGRN-305 and placebo groups.Conclusions and RelevanceThe findings of this trial suggest that heat shock protein 90 inhibition by RGRN-305 offers a novel mechanism of action in treating hidradenitis suppurativa, warranting further evaluation in larger trials.Trial RegistrationClinicalTrials.gov Identifier: NCT05286567
An Integrated Asymmetric Wet Adhesive Hydrogel with Gradient Charge Distribution Induced by Electrostatic Field
Authors: Xu Zhicheng , Liang Xuejiao , Ma Wencan , An Xiaoming , Wu Haomin , Zhang Qiuhong , Jia Xudong 
Published: December 2023

AbstractAdhesive hydrogels have been applied in biomedical field as an alternative to surgical sutures. However, there still exist rigorous challenges in rough underwater adhesion and asymmetric adhesion of hydrogels, especially applied in wound healing and organ repair in vivo. Herein, a strategy is proposed to prepare integrated hydrogels with asymmetric underwater adhesion capability by forming the asymmetric electrical interface under an electrostatic field. The synergistic effects between catechol and amine and complex coacervation are used to improve the underwater adhesion of hydrogel. Furthermore, by applying an electrostatic field, the cations and anions in solution of monomers are separated to form asymmetric adhesion interfaces. The hydrogel exhibits obvious asymmetric underwater adhesion ability on porcine skin with a strong adhesive strength of 97 kPa on cation side and 25 kPa on the anion side. Animal experiment outcomes reveal that only one side of the asymmetric hydrogel could adhere firmly to the rat liver and the rabbit stomach, while the other side could not effectively prevent postoperative tissue adhesion. The asymmetric distribution of adhesive molecules induced by electrostatic fields will provide a new alternative for designing and adjusting asymmetric adhesives after surgery.
Orthogonal Three‐Wavelength‐Controlled Two‐Stage Supramolecular Self‐Assemblies
Authors: Zhu Fengfan , Chen Xu‐Man , Ge Yang , Li Mengyao , Li Naixu , Zhou Jiancheng , Chen Wenshuai 
Published: December 2023

AbstractPhotoswitchable supramolecular self‐assemblies are promising candidates for intelligent recognition because of their noninvasive and spatial precision. However, the manipulation of the self‐assembly and disintegration of multicomponent mixtures with light of different wavelengths remain difficult. Here, an orthogonal three‐wavelength‐controlled two‐stage supramolecular self‐assembly consisting of two photoswitches, diarylethene, and protonated merocyanine is designed, mediated by supramolecular macrocyclic host. Owing to the reversible photo‐transformation of the switches, an optimized approach including three wavelengths irradiation and a thermal relaxation process is developed without mutual interference, realizing interconversion among four self‐assembled states. These self‐assemblies are photodeformable with reversibility, which can be operated in a cellular environment. Taking advantage of the photochromism in both absorption and fluorescence of these self‐assemblies in different behaviors, a visual pattern that can simultaneously display multiple hidden information under dual‐signal emission is created. This work signifies a promising strategy in improving the ability of information encryption and anti‐counterfeiting.
Improving the Stability of Halide Perovskites for Photo‐, Electro‐, Photoelectro‐Chemical Applications
Authors: Du Fenqi , Liu Xiaolong , Liao Jinfeng , Yu Dejian , Zhang Nan , Chen Yiwang , Liang Chao , Yang Shengchun , Fang Guojia 
Published: December 2023

AbstractOwing to their remarkable and adjustable optoelectronic properties, halide perovskites (HPs) have been regarded as a class of promising materials for various optoelectronic applications based on different energy conversion reactions, including photovoltaic cell, photocatalysis, electrocatalysis, and photoelectrochemical (PEC) systems. However, the low stability of HPs upon exposure to ambient conditions (e.g., water, heat, light, electricity) greatly hinders the practical applications of HPs. In the past few years, significant efforts have been devoted to enhancing the eventual stability of the perovskite‐based optoelectronic systems, mainly focusing on delivering improvements in the stabilities of halide perovskite materials and the relevant operation conditions of optoelectronic systems, which deserve in‐depth and systematic summaries. In this comprehensive review, the in‐depth environment‐induced decomposition mechanisms of typical HPs are elucidated. Simultaneously, the strategies for addressing the instability issues of halide perovskite materials are critically reviewed, including dimension control, compositional engineering, ligand passivation, and encapsulation engineering. Furthermore, the photoelectric applications based on the modified HPs and operation conditions are discussed systematically. In the last part of this review, future perspectives and outlooks toward the stability of HPs and their photoelectric applications are envisaged respectively.
Interfacial Engineering of Cobalt Thiophosphate with Strain Effect and Modulated Electron Structure for Boosting Electrocatalytic Hydrogen Evolution Reaction
Authors: Song Kai , Zhang Huanhuan , Lin Zhiping , Wang Zongpeng , Zhang Lili , Shi Xinxing , Shen Shijie , Chen Shichang , Zhong Wenwu 
Published: December 2023

AbstractThe fabrication of heterojunctions is an intriguing approach to boost the reactivity of catalysts. However, facile preparation of desirable heterojunction materials remains a challenge. Here, novel CoPS3/CoS2 heterojunctions are created by an intuitive phosphatization process on the basis of structurally flexible cobalt sulfide precursors. Significant stress effect exists at these heterogeneous interfaces, resulting in lattice distortions and the exposure of more active sites. The interface interaction also modifies the catalyst's electronic structure to improve its electrical conductivity and hydrogen adsorption capabilities. Notably, the overpotential of the CoPS3/CoS2 heterojunction for electrocatalytic hydrogen evolution reaction is just 36.3 mV, which is far superior to those of single‐component catalysts and competitive with comparable catalysts reported. This work not only offers an innovative electrocatalyst but also a strategy that can be used to create heterojunctions based on related transition metal thiophosphates.
Durable Radiative Cooling Multilayer Silk Textile with Excellent Comprehensive Performance
Authors: Wu Xun‐En , Wang Yida , Liang Xiaoping , Zhang Yong , Bi Peng , Zhang Mingchao , Li Shuo , Liang Huarun , Wang Shuai , Wang Haomin , Lu Haojie , Zhang Yingying 
Published: December 2023

AbstractPassive radiative cooling without energy consumption is increasingly being explored as an eco‐friendly alternative to electric cooling for mitigating heat stress caused by global warming. Incorporating radiative cooling into personal thermal management has garnered widespread interest. However, existing sub‐ambient radiative cooling textiles face challenges related to inferior solar reflectance, poor outdoor durability, or health concerns. Here, a durable multilayer silk textile (MST) is developed that achieves excellent comprehensive performance for the first time, including both ultrahigh solar reflectance (96.5%) and ultrahigh infrared emittance (97.1%), safety, air and moisture permeability, high mechanical strength, washability, abrasion resistance, surface hydrophobicity, and UV resistance. The MST achieves a remarkable sub‐ambient temperature drop of 5.1 °C under 892.4 W m−2 of ultra‐strong solar radiation and surpasses both commercial silk and cotton textiles at noon with temperature reductions of 6.0 and 8.3 °C, respectively. For proof of concept, a hat using the MST is fabricated, which shows improved cooling performance compared to commercial hats. Considering its outstanding cooling performance, durability, zero energy consumption, abundant raw materials, and scalable production ability, it is believed that the radiative cooling MST holds great promise for practical applications in daytime personal thermal management.
On‐Surface Ullmann‐Type Coupling: Reaction Intermediates and Organometallic Polymer Growth
Authors: Houtsma R.S. Koen , van Zuilen Jeanne , Stöhr Meike 
Published: December 2023

AbstractUllmann‐type coupling is the most widely used on‐surface reaction to form rationally designed bottom‐up molecular nanoarchitectures. A commonly observed reaction product in this reaction is an organometallic phase, however little is known about the formation of this phase. The on‐surface polymerization of the prochiral precursor 6,12‐dibromochrysene (DBCh) on Ag(111) is studied. Upon annealing of DBCh on Ag(111), a linear organometallic polymer forms. However, the delicate energy balance involved in the polymerization of DBCh is such that, at room temperature, several reaction intermediates, which eventually lead to the formation of the organometallic polymer, can be observed experimentally. Organometallic monomers, dimers, and trimers are finds, that self‐assemble into distinct networks. The experimental availability of these reaction intermediates provides key insights into the formation of the organometallic polymer. Comparing the chirality of the intermediates and the polymer sheds additional light on the reaction mechanism leading to the formation of the polymer. The main finding is that the organometallic polymer is not formed by a simple coupling of the reaction intermediates, but rather requires the breaking and re‐establishing of the C─Ag bonds. Additionally, a Br‐enhanced growth mode is observed, where the split‐off halogens align the polymers, which results in an increased polymer length.
Encapsulation of Disodium‐EDTA in Electrospun Polymeric Fibers for the Detection of Heavy Metals
Authors: Fotia Antonio , Frontera Patrizia , Bonaccorsi Lucio , Sciacca Beniamino , Malara Angela 
Published: December 2023

AbstractThe contamination by heavy metals (HMs) is a pressing issue, due to their serious impact on the environment and human health. Therefore, the design and the development of a sensing material for their detection has gained a lot of attention. In this study, active layers are produced by the electrospinning technique, using three different polymers and disodium salt of ethylenediaminetetraacetic acid (Na2‐EDTA), known to be a chelating substance for heavy metals. The optimized active layer, in terms of polymer type, degree of encapsulation of the salt, as well as salt suitable content, is obtained and tested using the electrochemical impedance spectroscopy technique. The results of the sensing tests indicate the suitability of the developed electrospun layer for environmental monitoring. It is shown the detection of lead in the range of 10–100 000 µg L−1, with a detection limit of 0.031 µg L−1. Moreover, the system is proved to be robust against interfering contaminants such as thallium, another relevant heavy metal.
Synthesis and biological evaluation of (2‐aminosulfonylpyridin‐6‐yl)pyrazolopyrimidinone derivatives as Wee1 inhibitors for cancer treatment
Authors: Kim Yeon Ju , Jung Myoung Eun , Lee Ju Yeong , Lee Yun‐Han , Choi Gildon , Jeon Moon‐Kook 
Published: December 2023

AbstractFor an analog‐based design of novel Wee1 inhibitors, we profiled in vitro ADMET and in vivo PK properties of adavosertib. Based on the properties of adavosertib, we aimed to improve its metabolic stability by designing a novel target compound 1a with an aminosulfonyl group instead of the 2‐hydroxypropan‐2‐yl moiety in adavosertib. Derivatives of target compound 1a were synthesized and evaluated for Wee1 enzyme inhibition and liver microsomal phase I stability. We identified compound 1a as a sub‐nanomolar Wee1 inhibitor and 10 additional compounds with one‐digit nanomolar Wee1 inhibitory activity, among which seven compounds including 1a exhibited improved metabolic stabilities compared with adavosertib. However, MDA‐MB‐231 cell growth inhibitory activities of all synthesized compounds and Wee1 substrate phosphorylation inhibitory activities of selected compounds were inferior to adavosertib overall. Moreover, the representative compound 1a exhibited low permeability, which may be the reason for the low cellular activities of compound 1a.
Cues associated with a single ethanol exposure elicit conditioned corticosterone responses in adolescent male but not female Sprague–Dawley rats
Authors: Gano Anny , Barney Thaddeus M. , Vore Andrew S. , Mondello Jamie E. , Varlinskaya Elena I. , Pautassi Ricardo M. , Deak Terrence 
Published: December 2023

AbstractIt has been shown that ethanol‐induced interleukin‐6 (IL‐6) in adult male Sprague–Dawley rats was sensitized by environmental stimuli paired with ethanol and was accompanied by a conditioned increase in corticosterone (CORT). Adolescent males showed ethanol‐induced IL‐6 conditioning more readily than adults. The present studies examined whether female adolescents display IL‐6 conditioning and whether adolescents of either sex show CORT conditioning. Male and female (N = 212, n = 6–10) adolescent (postnatal day 33–40) rats were given ethanol (2 g/kg intraperitoneal injection; the unconditioned stimulus), either paired with a lavender‐scented novel context (the conditioned stimulus) or explicitly unpaired from context. Rats were tested in the context without ethanol and brains/blood were collected. Adolescent females did not show signs of neuroimmune (Experiment 1) or CORT conditioning (Experiments 2–4). Paired males showed enhanced CORT to the scented context relative to unpaired counterparts when the interoceptive cue of a saline injection was used on test day (Experiment 2). Experiment 5 used a delayed conditioning procedure and showed that male paired adolescents showed significantly higher CORT in response to context, showing that classically conditioned CORT response was precipitated by environmental cues alone. These findings indicate that adolescent males may be predisposed to form conditioned associations between alcohol and environmental cues, contributing to adolescent vulnerability to long‐lasting ethanol effects.
Maternal psychological risk and the neural correlates of infant face processing: A latent profile analysis
Authors: Wall Kathryn M. , Penner Francesca , Dell Jaclyn , Lowell Amanda , Potenza Marc N. , Mayes Linda C. , Rutherford Helena J. V. 
Published: December 2023

AbstractMaternal psychological factors, including anxiety, depression, and substance use, may negatively affect parenting. Previous works with mothers have often assessed each of these factors in isolation despite their frequent co‐occurrence. Psychological factors have also been associated with neural processing of facial stimuli, specifically the amplitude (i.e., size) and latency (i.e., timing) of the face‐specific N170 event‐related potential. In the current study, 106 mothers completed measures assessing maternal psychological factors—anxiety, depression, and substance use. A latent profile analysis was used to identify profiles of psychological factors and assess profile associations with the N170 elicited by infant faces and with parental reflective functioning (PRF) as a measure related to caregiving. Two profiles (termed high and low psychological risk) were identified, with the higher risk profile associated with delayed N170 latency responses to infant faces. An exploratory analysis evidenced an indirect effect between the higher psychological risk profile and lower PRF through delayed N170 latency responses to infant faces. Taken together, maternal psychological risk across multiple indicators may together shape neural processing of infant faces, which may have downstream consequences for caregiving.
Fast sequential determination of amoxicillin and clavulanate in pharmaceutical samples using batch injection analysis with amperometric detection
Authors: Boane Anastácio A. , De Faria Lucas V. , Ramos David R. , Marra Mariana C. , Sousa Raquel M. F. , Muñoz Rodrigo A. A. , Richter Eduardo M. 
Published: December 2023

AbstractThe combination of amoxicillin (AMX) and clavulanic acid (CLA) is one of the most widely used antibiotic medicines in the world. This paper describes a novel electrochemical method for the fast sequential determination of AMX and CLA using batch injection analysis with amperometric detection (BIA‐AD) and boron‐doped diamond (BDD) as the working electrode. In the proposed strategy, AMX was selectively detected at +1.3 V and both compounds (AMX+CLA) at +1.8 V. The oxidation current from CLA was accessed by subtracting the currents detected at both potential pulses (i+1.8 V–i+1.3V) and using a simple correction factor. The developed method proved to be simple, cost‐effective, precise (RSD<1.3 %, n=10), rapid (>200 injection h−1), required simple sample preparation steps (dissolution and dilution only) and can be used in laboratories with minimal infrastructure (portable characteristics). The limits of detection were 0.31 (0.13) and 1.99 (0.47) μmol L−1 (mg L−1) for AMX and CLA, respectively. The results obtained by the proposed BIA‐AD method were comparable to those obtained by capillary electrophorese (95 % confidence level).