bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice
Authors: Iida Reiko , Ueki Misuzu , Yasuda Toshihiro 
Published: October 2023

AbstractM-LP/Mpv17L (Mpv17-like protein) is an atypical cyclic nucleotide phosphodiesterase (PDE) without the molecular structure characteristic of the PDE family. Deficiency of M-LP/Mpv17L in mice has been found to result in development of β-cell hyperplasia and improved glucose tolerance. Here, we report another phenotype observed in M-LP/Mpv17L-knockout (KO) mice: afferent cardiac hypertrophy. Although the hearts of M-LP/Mpv17L-KO mice did not differ in size from those of wild-type mice, there was marked narrowing of the left ventricular lumen and thickening of the ventricular wall. The diameter and cross-sectional area of cardiomyocytes in 8-month-old M-LP/Mpv17L-KO mice were increased 1.16-fold and 1.35-fold, respectively, relative to control mice, but showed no obvious abnormalities of cell structure, fibrosis or impaired cardiac function. In 80-day-old KO mice, the expression of hypertrophic marker genes, brain natriuretic peptide (BNF), actin alpha cardiac muscle 1 (ACTC1) and actin alpha 1 skeletal muscle (ACTA1), as well as the Wnt/β-catenin pathway target genes, lymphoid enhancer-binding factor-1 (LEF1), axis inhibition protein 2 (AXIN2) and transcription factor 7 (TCF7), was significantly up-regulated relative to control mice, whereas fibrosis-related genes such as fibronectin 1 (FN1) and connective tissue growth factor (CTGF) were down-regulated. Western blot analysis revealed increased phosphorylation of molecules downstream of the cAMP/PKA signaling pathway, such as β-catenin, ryanodine receptor 2 (RyR2), phospholamban (PLN) and troponin I (cTnI), as well as members of the MEK1-ERK1/2 signaling pathway, which is strongly involved in afferent cardiac hypertrophy. Taken together, these findings indicate that M-LP/Mpv17L is one of the PDEs actively functioning in the heart and that deficiency of M-LP/Mpv17L in mice promotes physiological cardiac hypertrophy.
The association between blood nickel level and handgrip strength in patients undergoing maintenance hemodialysis
Authors: Tang Ruiying , Chen Jiexin , Ma Huijuan , Deng Jihong , Zhang Yanxia , Xu Qingdong 
Published: October 2023

Abstract
Background
Progressive loss of peripheral muscle strength is highly pronounced in patients receiving maintenance hemodialysis (MHD), of which the pathological mechanism tends to be multifactorial. Plasma nickel was reportedly correlated with muscular strength in non-dialysis patients. However, scarce is known regarding the association between blood nickel level and handgrip strength among the patients undergoing MHD.

Methods
This cross-sectional study included patients undergoing MHD at our center in October 2021. Blood samples were collected before the hemodialysis sessions. Nickel level was measured using inductively coupled plasma mass spectrometry. Eligible patients were stratified into three groups by the blood nickel level: tertile 1 (≥ 5.2 ug/L); tertile 2 (< 5.2 ug/L and ≥ 4.5 ug/L); and tertile 3 (< 4.5 ug/L). Handgrip strength measurement was used to evaluate the muscle status. Spearman’s analyses and multivariable linear regression analyses were performed to study the relationship between blood nickel level and handgrip strength.

Results
A total of 236 patients were enrolled, with an average age of 55.51 ± 14.27 years and a median dialysis vintage of 83 (IQR: 48–125) months. Patients in group with a higher blood nickel level (tertile 1) tended to be female, had longer dialysis vintage and higher Kt/V, but lower BMI, serum creatinine, hemoglobin, and handgrip strength level (all p < 0.05). After adjustment for confounding factors in multivariable models, for every 1ug/L increase in nickel level, the patient’s handgrip strength decreases by 2.81 kg (β: − 2.810, 95% confidence interval: − 5.036 to − 0.584, p = 0.014). Restricted cubic spline confirmed the relationship was nearly linear.

Conclusions
Our study highlighted that blood nickel level was related to handgrip strength in patients undergoing MHD. Prospective studies with larger sample sizes are still needed to confirm the result.
Inferring Attention Shifts for Salient Instance Ranking
Authors: Siris Avishek , Jiao Jianbo , Tam Gary K. L. , Xie Xianghua , Lau Rynson W. H. 
Published: October 2023

AbstractThe human visual system has limited capacity in simultaneously processing multiple visual inputs. Consequently, humans rely on shifting their attention from one location to another. When viewing an image of complex scenes, psychology studies and behavioural observations show that humans prioritise and sequentially shift attention among multiple visual stimuli. In this paper, we propose to predict the saliency rank of multiple objects by inferring human attention shift. We first construct a new large-scale salient object ranking dataset, with the saliency rank of objects defined by the order that an observer attends to these objects via attention shift. We then propose a new deep learning-based model to leverage both bottom-up and top-down attention mechanisms for saliency rank prediction. Our model includes three novel modules: Spatial Mask Module (SMM), Selective Attention Module (SAM) and Salient Instance Edge Module (SIEM). SMM integrates bottom-up and semantic object properties to enhance contextual object features, from which SAM learns the dependencies between object features and image features for saliency reasoning. SIEM is designed to improve segmentation of salient objects, which helps further improve their rank predictions. Experimental results show that our proposed network achieves state-of-the-art performances on the salient object ranking task across multiple datasets. Code and data are available at https://github.com/SirisAvishek/Attention_Shift_Ranks.
One-pot synthesis of bimetallic Fe–Cu metal–organic frameworks composite for the elimination of organic pollutants via peroxymonosulphate activation
Authors: Fdez-Sanromán Antía , Rosales Emilio , Pazos Marta , Sanromán Angeles 
Published: October 2023

AbstractA series of bimetallic of FeCu metal–organic frameworks (MOFs) have been synthesised using a solvothermal process by varying the ratio between the two metals. Further, the bimetallic MOF catalysts were characterised by X-ray powder diffraction, scanning electron microscopy, and infrared spectroscopy techniques. Their catalytic properties for activation of peroxymonosulphate (PMS) have been tested by the removal of a model dye, rhodamine B. As a result, NH2–Fe2.4Cu1-MOF demonstrated the highest degradation, the effect of the ratio NH2–Fe2.4Cu1-MOF/PMS has been studied, and the main reactive species have been assessed. The application of these MOFs in powder form is difficult to handle in successive batch or flow systems. Thus, this study assessed the feasibility of growing NH2–Fe2,4Cu1-MOF on polyacrylonitrile (PAN) spheres using the one-pot solvothermal synthesis method. The optimisation of the catalytic activity of the synthesised composite (NH2–Fe2.4Cu1-MOF@PAN) has been evaluated by response surface methodology using a central composite face-centred experimental design matrix and selecting as independent variables: time, PMS concentration, and catalyst dosage. Based on the results, the optimisation of the operational conditions has been validated. At 2.5 mM PMS, 90 min, and 1.19 g·L−1 of catalyst dosage, maximum degradation (80.92%) has been achieved, which doubles the removal values obtained in previous studies with other MOFs. In addition, under these conditions, the catalyst has been proven to maintain its activity and stability for several cycles without activity loss.
Graphical Abstract
Analysis of entrepreneurs’ motivations and role models for growth expectations in the time of coronavirus
Authors: Calvo Nuria , Neira Isabel , Atrio Yago 
Published: October 2023

AbstractThe change in life and professional conditions in 2020 has impacted the growth expectations of new firms. Based on a sample of more than 20,000 people coming from the Spanish Global Entrepreneurship Monitor (GEM) for 2019 and 2020, we analyze the effect of entrepreneurs’ motivations and social role models on the growth expectations of new firms using a binomial logit model. The results show that, as a consequence of the institutional conditions caused by the COVID-19 pandemic, entrepreneurs only take into consideration the economic projections of the new firm in order to take the risk of hiring employees in the early stage of the firm’s creation. However, experienced entrepreneurs involved in the consolidating stage of the entrepreneurial process have more ambitious motivations, and take advantage of their knowledge derived from peer role models in order to face the new opportunities arising during the pandemic. The effect of motivations and role models on firms’ growth also differ between men and women.
Plastic Flow Instability in 304 Austenitic Stainless Steels at Room Temperature
Authors: Tabin J. , Nalepka K. , Kawałko J. , Brodecki A. , Bała P. , Kowalewski Z. 
Published: October 2023

AbstractA remarkable plastic flow instability is observed during tensile deformation of the commercial 304 stainless-steel sheet at room temperature. It has been found that the occurrence of plastic flow instability in 304 is dependent on the strain rate and specimen gage length. Moreover, it is essentially the same as the necking caused by plastic instability in 316L. However, the enhanced strain hardening resulting from deformation-induced martensitic transformation facilitates the orderly propagation of the strain-localized band.
Graphical Abstract
Type 2 Diabetes Remission After Bariatric Surgery and Its Impact on Healthcare Costs
Authors: Canakis Andrew , Wall-Wieler Elizabeth , Liu Yuki , Zheng Feibi , Sharaiha Reem Z. 
Published: October 2023

Abstract
Purpose
Bariatric surgery is the most effective and durable treatment of obesity and can put type 2 diabetes (T2D) into remission. We aimed to examine remission rates after bariatric surgery and the impacts of post-surgical healthcare costs.

Materials and Methods
Obese adults with T2D were identified in Merative™ (US employer–based retrospective claims database). Individuals who had bariatric surgery were matched 1:1 with those who did not with baseline demographic and health characteristics. Rates of remission and total healthcare costs were compared at 6–12 and 6–36 months after the index date.

Results
Remission rates varied substantially by baseline T2D complexity; differences in rates at 1 year ranged from 41% for those with high-complexity T2D to 66% for those with low- to mid-complexity T2D. At 3 years, those who had bariatric surgery had 56% higher remission rates than those who did not have bariatric surgery, with differences of 73%, 59%, and 35% for those with low-, mid-, and high-complexity T2D at baseline. Healthcare costs were $3401 and $20,378 lower among those who had bariatric surgery in the 6 to 12 months and 6 to 36 months after the index date, respectively, than their matched controls. The biggest cost differences were seen among those with high-complexity T2D; those who had bariatric surgery had $26,879 lower healthcare costs in the 6 to 36 months after the index date than those who did not.

Conclusion
Individuals with T2D undergoing bariatric surgery have substantially higher rates of T2D remission and lower healthcare costs.

Graphical Abstract
Stepanov and Weyl Classes of c-Almost Periodic Type Functions
Authors: Ounis Hadjer , Sepulcre Juan Matías 
Published: October 2023

AbstractAs an extension of some classes of generalized almost periodic functions, in this paper we develop the notion of c-almost periodicity in the sense of Stepanov and Weyl approaches. In fact, we extend some basic results of this theory which were already demonstrated for the standard cases. In particular, we prove that every c-almost periodic function in the sense of Stepanov approach (in the sense of equi-Weyl or Weyl approaches, respectively) is also $$c^m$$

c
m

-almost periodic in the sense of Stepanov approach (in the sense of equi-Weyl or Weyl approaches, respectively) for each non-zero integer number m. This study is performed for both representative cases of functions defined on the real axis and with values in a Banach space and the complex functions defined on vertical strips in the complex plane.
Reviews, Challenges, and Insights on Computational Methods for Network Reconfigurations in Smart Electricity Distribution Networks
Authors: El-Fergany Attia A. 
Published: October 2023

AbstractPower losses and voltage profiles in electricity distribution networks are a problem, particularly in developing nations. Many techniques have reportedly been used in the previous ten years to address this issue. Among other solutions, network reconfigurations (NRs) are regarded as one of the most practical. It is important to conduct a periodic update survey on this subject because the electricity radial distribution networks (RDNs) are continually evolving. Therefore, a thorough evaluation of the various techniques to address the issues with NRs along distribution networks is provided in this manuscript. There is discussion of several mathematical, traditional, heuristic-based, and machine-learning strategies. It is important to understand how the radiality is achieved as well as methods for resolving distribution load flow, particularly with greater R/X ratios. The most typical test cases used in the literature are listed. In order to enrich this review and make it useful to others, more than 200 articles (the majority of which were published in the last five years) are referenced inside the body of this text. The final conclusions and related future insights are presented. At last, this work is an invaluable resource for anyone involved in this field of study because it offers a comprehensive literary framework that can serve as the foundation for any future research on NRs and its prospective difficulties. Therefore, academics can use this framework to enhance previous formulations and approaches as well as suggest more effective models.
Synthesis of Galacto-oligosaccharides in Milk
by Using Bifidobacterium bifidum β-galactosidases
(Saphera 2600L and Nola Fit 5500) Immobilized on Chitosan Beads
Authors: Bodnár Magdolna , Fazekas Erika , Nagy Tibor , Miltner Noémi , Kalló Gergő , Kerekes Krisztina , Prépost Eszter , Mótyán János András 
Published: October 2023

AbstractThe lactose intolerance—as a limiting factor for dairy milk
consumption—has a high prevalence worldwide. Dairy milk and milk-derived products
are major sources of multiple inorganic compounds and nutrients and thus are
considered to be functional foods. β-galactosidases are able to hydrolyze lactose
and are therefore widely applied for the production of lactose-free products. In
addition, they are capable of the synthesis of galacto-oligosaccharides (GOSs);
thus, the dairy industry has a special interest in applying them for the enrichment
of dairy products with prebiotic GOSs. In this work, we studied two commercially
available β-galactosidase products: Saphera 2600L and Nola Fit 5500. Both enzyme
solutions contain a recombinant β-galactosidase of Bifidobacterium bifidum and have already been authorized for food
industrial application, but the information about their hydrolytic and/or synthetic
activities is only limited. After immobilization on chitosan beads, the enzymes were
used for lactose hydrolysis and simultaneous synthesis of GOSs, by performing the
reactions in pasteurized milk (skim milk). Both immobilized β-galactosidase
exhibited elevated lactose hydrolysis (vmax increased
from ~ 1 to ~ 4 mM/min) and GOS synthesis as compared to the free enzymes. The
enzyme-coated beads were efficiently re-used at least 15 cycles; the residual
lactose concentration was < 2 mg/ml after each cycle. After treatment, GOSs were
present in ≤ 9% of the total sugar content, indicating that the prepared low-lactose
milks were enriched in prebiotic GOSs. The application of immobilized Saphera 2600L
and Nola Fit 5500 β-galactosidases may be implemented for the large-scale production
of GOS-enriched low-lactose milk.
Graphical Abstract
Clinical implications of augmented renal clearance after unrelated single cord blood transplantation in adults
Authors: Konuma Takaaki , Takano Kosuke , Monna-Oiwa Maki , Isobe Masamichi , Kato Seiko , Takahashi Satoshi , Nannya Yasuhito 
Published: October 2023

AbstractAugmented renal clearance (ARC) is a phenomenon characterized by increased renal functionality, which can impact the pharmacokinetics and pharmacodynamics of antimicrobial drugs eliminated by the kidneys. It is a potential concern for infection treatment. Cord blood transplantation (CBT) is primarily impeded by delayed neutrophil recovery and immune reconstitution, thereby increasing susceptibility to infection. However, the clinical implications of ARC following CBT remain unexplored. We retrospectively assessed the influence of ARC on post-transplant outcomes at various time points in 194 adult recipients of single-unit unrelated CBT between 2007 and 2022 at our institution. ARC was observed in 52.9% of patients at 1 day, 39.8% at 15 days, and 26.5% at 29 days post-CBT. ARC was not significantly associated with bloodstream infection, acute graft-versus-host disease, or veno-occlusive disease/sinusoidal obstruction syndrome at any time point. ARC at 1 day, 15 days, and 29 days post-CBT was not significantly associated with overall survival, non-relapse mortality, or relapse rates. These findings suggest that ARC is common in adults during the early stages of CBT, but does not discernibly influence clinical outcomes or post-CBT complications.
A Case of Anti-Ma2 Encephalitis Presenting with Pendular Torsional Nystagmus
Authors: Vaghi Gloria , Vegezzi Elisa , Bini Paola , Gastaldi Matteo , Diamanti Luca , Marchioni Enrico , Colnaghi Silvia 
Published: October 2023

AbstractAntibodies against the neuronal protein Ma2 have been reported in a peculiar form of paraneoplastic encephalitis with prominent involvement of the limbic, brainstem, and diencephalic structures and usually associated with germ cell testicular, lung, or breast cancer. The diagnosis is frequently challenged by atypical clinical manifestations including parkinsonism, sleep disturbances, hypothalamic-pituitary dysfunctions, and motor neuron-like syndrome. In recent years, the advent of monoclonal antibodies targeting immune checkpoints has deeply changed the treatment of different tumors, especially melanoma and lung cancer. However, given their nature, an increasing number of neurological immune-related adverse events, including ocular motor abnormalities, have been described. Here, we report a woman with advanced non-small cell lung cancer treated with anti-PD-L1 durvalumab, presenting with an isolated pendular torsional nystagmus, in association with anti-Ma2 antibodies. This peculiar case widens our knowledge on the clinical presentation of anti-Ma2 encephalitis associated with checkpoint inhibitors.
Intracerebral Administration of a Novel Self-Assembling Peptide Hydrogel Is Safe and Supports Cell Proliferation in Experimental Intracerebral Haemorrhage
Authors: Bolan Faye , Dickie Ben R. , Cook James R. , Thomas Josephine M. , Pinteaux Emmanuel , Allan Stuart M. , Saiani Alberto , Lawrence Catherine B. 
Published: October 2023

AbstractIntracerebral haemorrhage (ICH) is the deadliest form of stroke, but current treatment options are limited, meaning ICH survivors are often left with life-changing disabilities. The significant unmet clinical need and socioeconomic burden of ICH mean novel regenerative medicine approaches are gaining interest. To facilitate the regeneration of the ICH lesion, injectable biomimetic hydrogels are proposed as both scaffolds for endogenous repair and delivery platforms for pro-regenerative therapies. In this paper, the objective was to explore whether injection of a novel self-assembling peptide hydrogel (SAPH) Alpha2 was feasible, safe and could stimulate brain tissue regeneration, in a collagenase-induced ICH model in rats. Alpha2 was administered intracerebrally at 7 days post ICH and functional outcome measures, histological markers of damage and repair and RNA-sequencing were investigated for up to 8 weeks. The hydrogel Alpha2 was safe, well-tolerated and was retained in the lesion for several weeks, where it allowed infiltration of host cells. The hydrogel had a largely neutral effect on functional outcomes and expression of angiogenic and neurogenic markers but led to increased numbers of proliferating cells. RNAseq and pathway analysis showed that ICH altered genes related to inflammatory and phagocytic pathways, and these changes were also observed after administration of hydrogel. Overall, the results show that the novel hydrogel was safe when injected intracerebrally and had no negative effects on functional outcomes but increased cell proliferation. To elicit a regenerative effect, future studies could use a functionalised hydrogel or combine it with an adjunct therapy.
Negotiating Monolingual Official Language Policy at the Nexus of Locally Situated Language Practices and Dominant Language Ideologies in a Language Minority Context
Authors: Lytra Vally , Gelir Iskender 
Published: October 2023

AbstractThis paper examines how children and teachers negotiate the official Turkish only language policy as they manage their linguistic resources (Turkish and Kurmanji) in one Turkish preschool serving predominantly emergent bilingual Kurdish minority children. Using a critical ethnographic lens to language-in-education policy making (Martin-Jones and Da Costa Gabral, in: Tollefson, Pérez-Milans (eds) The Oxford handbook of language policy and planning, Oxford University Press, 2018), the study investigates how children and teachers navigate locally situated language practices and language ideologies that accord legitimacy and authority to standard Turkish and officially invisibilise Kurmanji in the preschool. Findings indicate that acting as agentive social actors teachers and children do not merely comply to the Turkish only language policy but they also adapt, recast, and contest it in social interaction. They stress the need to rethink the language-in-education policy in the Turkish educational system in ways that recognise and leverage teachers and children’s entire linguistic repertoires and experiences for teaching and learning.
Clearing our Minds for Hedonic Phenomenalism
Authors: Buscicchi Lorenzo , van der Deijl Willem 
Published: October 2023

AbstractWhat constitutes the nature of pleasure? According to hedonic phenomenalism, pleasant experiences are pleasant in virtue of some phenomenological features. According to hedonic attitudinalism, pleasure involves an attitude—a class of mental states that necessarily have an object. Consequently, pleasures are alwaysaboutsomething. We argue that hedonic attitudinalism is not able to accommodate pleasant moods. We first consider this argument more generally, and then consider what we callthe globalist strategy responseto the possible objectless of moods, namely that pleasant moods have general, or undetermined, objects. We then discuss the case of blissful meditative states, and argue that the globalist strategy is not able to accommodate all pleasant states.
Marcinkiewicz exponent and boundary value problems in fractal domains of $${\mathbb {R}}^{n+1}$$
Authors: Tamayo Castro Carlos Daniel 
Published: October 2023

AbstractThis paper aims to study the jump problem for monogenic functions in fractal hypersurfaces of Euclidean spaces. The notion of the Marcinkiewicz exponent has been taken into consideration. A new solvability condition is obtained, basing the work on specific properties of the Teodorescu transform in Clifford analysis. It is shown that this condition improves those involving the Minkowski dimension.