bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traumatic Brain Injury and Subsequent Risk of Brain Cancer in US Veterans of the Iraq and Afghanistan Wars
Authors: Stewart Ian J. , Howard Jeffrey T. , Poltavskiy Eduard , Dore Michael , Amuan Megan E. , Ocier Krista , Walker Lauren E. , Alcover Karl C. , Pugh Mary Jo 
Published: February 2024

ImportanceWhile brain cancer is rare, it has a very poor prognosis and few established risk factors. To date, epidemiologic work examining the potential association of traumatic brain injury (TBI) with the subsequent risk of brain cancer is conflicting. Further data may be useful.ObjectiveTo examine whether a history of TBI exposure is associated with the subsequent development of brain cancer.Design, Setting, and ParticipantsA retrospective cohort study was conducted from October 1, 2004, to September 20, 2019, and data analysis was performed between January 1 and June 26, 2023. The median follow-up for the cohort was 7.2 (IQR, 4.1-10.1) years. Veterans Affairs (VA) and Department of Defense (DoD) administrative data on 1 919 740 veterans from the Long-Term Impact of Military-Relevant Brain Injury Consortium–Chronic Effects of Neurotrauma Consortium were included.ExposureThe main exposure of interest was TBI severity (categorized as mild, moderate or severe [moderate/severe], and penetrating).Main Outcomes and MeasuresThe outcome of interest was the development of brain cancer based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) or International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes in either the DoD/VA medical records or from the National Death Index.ResultsAfter 611 107 exclusions (predominately for no encounter during the study period), a cohort including 1 919 740 veterans was included, most of whom were male (80.25%) and non-Hispanic White (63.11%). Median age at index date was 31 (IQR, 25-42) years. The cohort included 449 880 individuals with TBI (mild, 385 848; moderate/severe, 46 859; and penetrating, 17 173). Brain cancer occurred in 318 individuals without TBI (0.02%), 80 with mild TBI (0.02%), 17 with moderate/severe TBI (0.04%), and 10 or fewer with penetrating TBI (≤0.06%). After adjustment, moderate/severe TBI (adjusted hazard ratio [AHR], 1.90; 95% CI, 1.16-3.12) and penetrating TBI (AHR, 3.33; 95% CI, 1.71-6.49), but not mild TBI (AHR, 1.14; 95% CI, 0.88-1.47), were associated with the subsequent development of brain cancer.Conclusions and RelevanceIn this cohort study of veterans of the Iraq and Afghanistan wars, moderate/severe TBI and penetrating TBI, but not mild TBI, were associated with the subsequent development of brain cancer.
Non‐Destructive Tomographic Nanoscale Imaging of Ferroelectric Domain Walls
Authors: He Jiali , Zahn Manuel , Ushakov Ivan N. , Richarz Leonie , Ludacka Ursula , Roede Erik D. , Yan Zewu , Bourret Edith , Kézsmárki István , Catalan Gustau , Meier Dennis 
Published: February 2024

AbstractExtraordinary physical properties arise at polar interfaces in oxide materials, including the emergence of 2D electron gases, sheet‐superconductivity, and multiferroicity. A special type of polar interface is ferroelectric domain walls, where electronic reconstruction phenomena can be driven by bound charges. Great progress has been achieved in the characterization of such domain walls and, over the last decade, their potential for next‐generation nanotechnology has become clear. Established tomography techniques, however, are either destructive or offer insufficient spatial resolution, creating a pressing demand for 3D imaging compatible with future fabrication processes. Here, non‐destructive tomographic imaging of ferroelectric domain walls is demonstrated using secondary electrons. Utilizing conventional scanning electron microscopy (SEM), the position, orientation, and charge state of hidden domain walls are reconstructed at distances up to several hundreds of nanometers away from the surface. A mathematical model is derived that links the SEM intensity variations at the surface to the local domain wall properties, enabling non‐destructive tomography with good noise tolerance on the timescale of seconds. The SEM‐based approach facilitates high‐throughput screening of materials with functional domain walls and domain‐wall‐based devices, which is essential for monitoring during the production of device architectures and quality control in real‐time.
Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy
Authors: Li Yue , Du Zekun , Zhang Yuan , Kang Xiaoying , Song Jianwen , Chen Xiaodong , Hu Yuanbo , Yang Zhimou , Qi Ji , Shen Xian 
Published: February 2024

AbstractHigh‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer for robust cancer immunotherapy. The AIEgen with dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating AIEgen into porous PBNPs, and further enveloped within M1 macrophage membrane, a tumor‐specific theranostic nanoagent is constructed. This strategic integration effectively constrains the molecular motion of AIEgen, leading to amplified NIR‐II fluorescence brightness and PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H2O2 to generate oxygen to boost PDT efficacy, and PB's NIR absorption also intensifies photoacoustic imaging and photothermal effect. The integration of NIR‐II fluorescence and photoacoustic imaging provides comprehensive information for photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, the nanoagent not only significantly inhibits cancer growth, but also generates a whole‐cell therapeutic cancer vaccine to protect mice from tumor rechallenge. In highly malignant post‐surgery breast cancer models, the nanoagent enables both accurate identification of residual tumors and efficient inhibition of postoperative tumor recurrence and pulmonary metastasis. This study will offer valuable insights for creating highly efficacious and multifaceted photoimmunotherapy protocols.
Design of High‐Performance Cubic N‐Type AgBiSe2 Guided by Metavalent Bonding Mechanism
Authors: Guo Zhentao , Zhu Yu‐Ke , Zhu Jianbo , Liu Ming , Dong Xingyan , Guo Fengkai , Cai Wei , Sui Jiehe , Liu Zihang 
Published: February 2024

AbstractAgBiSe2 undergoes two structural transitions in its service temperature range. Increasing entropy by alloying is considered an effective solution for modulating phase transition, but the efficacy of increasing entropy is limited by solubility and the selection of alloying components depends on trial and error. This study first confirmes that trigonal AgBiSe2 is metavalently bonded and searches metavalent PbTe as the alloying material based on the 2D map spanned by quantitative chemical bonding descriptors of electrons transferred (ET) and electrons shared (ES). The large solubility can be explained by the same bonding mechanism. PbTe alloying successfully stabilizes cubic AgBiSe2 to room temperature. Further, by optimizing the carrier concentration, the average ZT value from 300 to 773 K of (AgBiSe2)0.7(PbTe)0.3Cu0.02 reaches 0.42, which is 40% higher than that of pristine AgBiSe2. Simultaneously, heavy alloying leads to solid solution strengthening with enhanced hardness. This study not only paves the way for practical applications of AgBiSe2‐based materials but also provides an effective strategy for screening potential alloying candidates to solve the structure‐transition issue from the viewpoint of chemical bonding.
Magnetic Field‐Assisted Water Splitting: Mechanism, Optimization Strategies, and Future Perspectives
Authors: Ma Shengyu , Fu Qiang , Han Jiecai , Yao Tai , Wang Xianjie , Zhang Zhihua , Xu Ping , Song Bo 
Published: February 2024

AbstractRationally designing of highly efficient electrocatalysts is critical to improving hydrogen production by water electrolysis. However, bottlenecks still require consideration when optimizing the intrinsic performance of electrocatalysts. Applying appropriate external fields to catalytic systems may effectively overcome such bottlenecks and enhance the performance of catalysts. Among various external fields, the magnetic field has received extensive attention owing to its multifunctionality, non‐contact nature, and non‐invasiveness, thereby requiring more research and development. In this review, recent advances in magnetic field‐assisted water electrolysis are systematically outlined. Firstly, the diverse methods used for pre‐regulating catalysts under magnetic fields, including optimized nucleation, induction heating, and directed growth, are discussed. It then explores the effects of magnetic fields on electrochemical processes, including magnetothermal, magnetohydrodynamic, and induced electric impact. Then, the influences of magnetic fields on the intrinsic properties of catalysts, such as spin polarization and spin reconstruction effects, are addressed. Finally, a discussion of the potential perspectives of magnetic field‐enhanced water splitting, including catalyst design, experimental precision, and in situ characterization, are then provided to guide further research.
Self‐Floating Photocatalytic System for Highly Efficient Hydrogen Peroxide Production and Organic Synthesis on Carbon Dots Decorated Conjugated Microporous Polymer
Authors: Li Xueqing , Zhang Guping , Li Najun , Xu Qingfeng , Li Hua , Lu Jianmei , Chen Dongyun 
Published: February 2024

AbstractPhotocatalytic oxygen (O2) reduction to hydrogen peroxide (H2O2) is considered to be a promising method for energy storage. However, it suffers from the rapid recombination of carriers, the limited solubility and slow diffusion of O2, and the self‐decomposition of H2O2 in traditional diphase systems. Here, a self‐floating carbon dots/conjugated microporous polymer (CDs/CMP) photocatalytic system is established for H2O2 production and organic synthesis. Due to the D–π–A structure, porous structure, and hydrophobicity, CMP induced the intramolecular charge transfer, exposed abundant reaction sites, and enhanced O2 adsorption. CDs act as “bridges” for electron transmission and regulate the surface hydrophobicity of CMP, further improving charge transfer and optimizing the reaction interface. CDs/CMP system exhibits a high H2O2 production of 8542.6 µmol g−1 h−1 and concurrent furoic acid production at 2.22 mm h−1. This H2O2 production rate is ≈90% higher than that in the diphase system, exceeding all previously reported photocatalysts in triphase systems. Notably, the CDs/CMP system achieves the relative separation of the photocatalysts and H2O2, suppressing the generated H2O2 self‐decomposition. Theoretical calculations and in situ characterizations reveal the mechanism of H2O2 and furoic acid evolution. This self‐floating system provides insights into exploring the application of metal‐free photocatalysts in heterogeneous reactions.
Narrow‐Band Green‐Emitting Hybrid Organic–Inorganic Eu (II)‐Iodides for Next‐Generation Micro‐LED Displays
Authors: Han Kai , Jin Jiance , Zhou Xinquan , Duan Yan , Kovalenko Maksym V. , Xia Zhiguo 
Published: February 2024

AbstractLow‐dimensional metal halide perovskites are an emerging class of light‐emitting materials for LED‐based displays; however, their B‐site cations are confined to ns2, d5, and d10 metals. Here, the design of divalent rare earth ions at B‐site is presented and a novel Eu(II)‐based iodide hybrid is reported with efficient (PLQY ≈98%) narrow‐band (FWHM ≈43 nm) green emission and high thermal stability (97%@150 °C). Owing to reduced lattice vibrations and shrunken average distance of Eu(II)‐iodide bonds in the face‐sharing 1D‐structure, photoluminescence from Eu(II) 4f‐5d transition appears along with elevated crystal‐field splitting of 5d energy level. The Eu(II)‐based iodide hybrid is further demonstrated for color‐pure green phosphor‐converted LEDs with a maximum brightness of ≈396 000 cd m−2 and photoelectric efficiency of 29.2%. High‐resolution micrometer‐scale light‐emitting diode (micro‐LED) displays (2540 PPI) via the solution‐processed screen is also presented. This work thus showcases a compelling narrow‐band green emitter for commercial micro‐LED displays.
Conformation Changes Associated with the Formation and Activation of Lysine Tyrosylquinone of LOXL2 Studied by Metadynamics Simulation
Authors: Wang Yiwen , Lin Lirui , Xu Li‐Yan , Li En‐Min , Dong Geng 
Published: February 2024

AbstractLysyl oxidase‐like 2 (LOXL2) is a Cu2+‐dependent amine oxidase that catalyzes the oxidative deamination of lysine residues of elastin and collagen to generate aldehyde groups. In the active state of LOXL2, its conserved catalytic domain has a lysine tyrosylquinone (LTQ) cofactor and a copper ion. LTQ is post‐translationally derived from Lys653 and Tyr689 of LOXL2. In this study, well‐tempered metadynamics simulations are used to investigate the conformation modulation from the inactive state to active state and obtain the free energy landscape. Interestingly, the simulations show that LTQ precursor residues cannot get close in Zn2+−bound LOXL2, whereas the copper ion binding triggers a conformation change to form an optional structure for LTQ biosynthesis. It is found that a prominent loop, consisting of residues 654–658, hinders the formation of LTQ in Zn2+−LOXL2 by preventing Lys653 from moving into active site of LOXL2, whereas this loop is relatively flexible in Cu2+−LOXL2. After the formation of LTQ, it needs to be activated by adjusting its position to be exposed to the solvent, thus allowing it to react with its substrate proteins. The results indicate that this process involves an intermediate state and that the activation of LTQ overcomes an energy barrier of 5.9 kcal mol−1.
Evoked Weibel‐Palade Body Exocytosis Modifies the Endothelial Cell Surface by Releasing a Substrate‐Selective Phosphodiesterase
Authors: Naß Johannes , Terglane Julian , Zeuschner Dagmar , Gerke Volker 
Published: February 2024

AbstractWeibel Palade bodies (WPB) are lysosome‐related secretory organelles of endothelial cells. Commonly known for their main cargo, the platelet and leukocyte receptors von‐Willebrand factor (VWF) and P‐selectin, WPB play a crucial role in hemostasis and inflammation. Here, the authors identify the glycerophosphodiester phosphodiesterase domain‐containing protein 5 (GDPD5) as a WPB cargo protein and show that GDPD5 is transported to WPB following uptake from the plasma membrane via an unique endocytic transport route. GDPD5 cleaves GPI‐anchored, plasma membrane‐resident proteins within their GPI‐motif, thereby regulating their local activity. The authors identify a novel target of GDPD5 , the complement regulator CD59, and show that it is released from the endothelial surface by GDPD5 following WPB exocytosis. This results in increased deposition of complement components and can enhance local inflammatory and thrombogenic responses. Thus, stimulus‐induced WPB exocytosis can modify the endothelial cell surface by GDPD5‐mediated selective release of a subset of GPI‐anchored proteins.
Convergence of Nanotechnology and Bacteriotherapy for Biomedical Applications
Authors: Liu Jun , Yuan Sichen , Bremmer Alexa , Hu Quanyin 
Published: February 2024

AbstractBacteria have distinctive properties that make them ideal for biomedical applications. They can self‐propel, sense their surroundings, and be externally detected. Using bacteria as medical therapeutic agents or delivery platforms opens new possibilities for advanced diagnosis and therapies. Nano‐drug delivery platforms have numerous advantages over traditional ones, such as high loading capacity, controlled drug release, and adaptable functionalities. Combining bacteria and nanotechnologies to create therapeutic agents or delivery platforms has gained increasing attention in recent years and shows promise for improved diagnosis and treatment of diseases. In this review, design principles of integrating nanoparticles with bacteria, bacteria‐derived nano‐sized vesicles, and their applications and future in advanced diagnosis and therapeutics are summarized.
Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection
Authors: Wang Tianyou , Guo Linghong , Wu Shuwei , Xu Yuanyuan , Song Junmei , Yang Yi , Zhang Hengjie , Li Dongcui , Li Yiwen , Jiang Xian , Gu Zhipeng 
Published: February 2024

AbstractNatural evolution has nurtured a series of active molecules that play vital roles in physiological systems, but their further applications have been severely limited by rapid deactivation, short cycle time, and potential toxicity after isolation. For instance, the instability of structures and properties has greatly descended when sanshool is derived from Zanthoxylum xanthoxylum. Herein, natural polyphenols are employed to boost the key properties of sanshool by fabricating a series of nanoparticles (NPs). The intracellular evaluation and in vivo animal model are conducted to demonstrate the decreased photodamage score and skin‐fold thickness of prepared NPs, which can be attributed to the better biocompatibility, improved free radical scavenging, down‐regulated apoptosis ratios, and reduced DNA double‐strand breaks compared to naked sanshool. This work proposes a novel strategy to boost the key properties of naturally occurring active molecules with the assistance of natural polyphenol‐based platforms.
Land consolidation, cropland use, and vegetation productivity
Authors: Demirdogen Alper 
Published: February 2024

AbstractLand consolidation represents a valuable tool for enhancing agricultural productivity. However, there is a notable gap in the literature, with few studies effectively estimating the impact of land consolidation on microlevel crop changes. In our study, we estimated how land consolidation affects cropland use and vegetation productivity in Turkey, specifically examining wheat and corn. To analyze microlevel datasets from various villages, we applied multiple difference‐in‐differences approaches. Our results show that land consolidation affects farmers' cropland usage, particularly transitioning from wheat to corn. Land consolidation also leads to increased yields for both wheat and corn, although these benefits are not long‐lasting and diminish within a few years. Thus, our findings provide valuable insights for land‐use policy and planning, highlighting the critical role of land consolidation in determining farmers' cropland uses and its effect on overall productivity [EconLit Citations: Q12, Q15, Q18].
Increasing support for the prevention of adverse childhood experiences and substance use: Implementation of narrative change strategies in local health departments
Authors: Harper Christopher R. , Tan‐Schriner Cheribeth , Royster Jordan , Morgan Karie L. , Burnett Vanessa , Treves‐Kagan Sarah , Bradford Joivita , Ettman Leah , Espinosa Oscar , Marziale Erin 
Published: February 2024

AbstractAdverse childhood experiences (ACEs) are potentially traumatic but preventable experiences that occur before the ages of 18, including child abuse, witnessing violence, and parental substance use. ACEs have been linked with increased risk for substance use, along with a variety of other negative health outcomes. However, there is limited evidence of community‐level strategies that link ACEs and substance to increase awareness of prevention efforts. This article reports on a $2.9 million program to promote health equity and inform narratives for the prevention of ACEs and substance use within three Midwestern communities. Program partners sought to create new transformational narratives that linked ACEs and substance use, while underscoring the importance of addressing social determinants of health (SDOH) that lead to disparities in ACEs and substance use. A mixed‐methods evaluation design included document review, in‐depth interviews with program staff (N = 8) and community liaisons (N = 2), and site reports from program staff (N = 8) and their community partners (N = 17). Analyses showed that successful implementation efforts had early leadership buy‐in and support, set clear and manageable expectations at the outset of implementation, and developed strong relationships with organizations that engage in health equity work. Training and technical assistance were critical to helping community partners build trust, recognize each other's perspectives, broaden and reframe their world view, and better understand narrative efforts for the primary prevention of ACEs and substance use.
Splenic irradiation for myelofibrosis prior to hematopoietic cell transplantation: A global collaborative analysis
Authors: Gagelmann Nico , Hobbs Gabriela S. , Campodonico Edoardo , Helbig Grzegorz , Novak Polona , Schroeder Thomas , Schneider Artur , Rautenberg Christina , Reinhardt Hans Christian , Bosques Linette , Heuser Michael , Panagiota Victoria , Thol Felicitas , Gurnari Carmelo , Maciejewski Jaroslaw P. , Ciceri Fabio , Rathje Kristin , Robin Marie , Pagliuca Simona , Rubio Marie‐Thérèse , Rocha Vanderson , Funke Vaneuza , Hamerschlak Nelson , Salit Rachel , Scott Bart L. , Duarte Fernando , Mitrus Iwona , Czerw Tomasz , Greco Raffaella , Kröger Nicolaus 
Published: February 2024

AbstractSplenomegaly is the clinical hallmark of myelofibrosis. Splenomegaly at the time of allogeneic hematopoietic cell transplantation (HCT) is associated with graft failure and poor graft function. Strategies to reduce spleen size before HCT especially after failure to Janus kinase (JAK) inhibition represent unmet clinical needs in the field. Here, we leveraged a global collaboration to investigate the safety and efficacy of splenic irradiation as part of the HCT platform for patients with myelofibrosis. We included 59 patients, receiving irradiation within a median of 2 weeks (range, 0.9–12 weeks) before HCT. Overall, the median spleen size prior to irradiation was 23 cm (range, 14–35). Splenic irradiation resulted in a significant and rapid spleen size reduction in 97% of patients (57/59), with a median decrease of 5.0 cm (95% confidence interval, 4.1–6.3 cm). The most frequent adverse event was thrombocytopenia, with no correlation between irradiation dose and hematological toxicities. The 3‐year overall survival was 62% (95% CI, 48%–76%) and 1‐year non‐relapse mortality was 26% (95% CI, 14%–38%). Independent predictors for survival were severe thrombocytopenia and anemia before irradiation, transplant‐specific risk score, higher‐intensity conditioning, and present portal vein thrombosis. When using a propensity score matching adjusted for common confounders, splenic irradiation was associated with significantly reduced relapse (p = .01), showing a 3‐year incidence of 12% for splenic irradiation versus 29% for patients with immediate HCT and 38% for patients receiving splenectomy. In conclusion, splenic irradiation immediately before HCT is a reasonable approach in patients experiencing JAK inhibition failure and is associated with a low incidence of relapse.