bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B039: T cell recruitment dynamics at different stages of primary and metastatic colorectal cancer
Authors: Saad Marwa A , Bilate Angelina , Mucida Daniel 
Published: December 2023

Abstract
Colorectal cancer (CRC) is the fourth deadliest cancer worldwide, primarily due to metastasis. The current standard therapy for patients with CRC includes neoadjuvant therapies combined with surgery, often resulting in severe complications that affect patients’ lifestyles. Hence, there is a critical need to improve our understanding of the tumor microenvironment to improve the current therapeutics for metastatic CRC. We characterized T cell dynamics in response to tumors at early (1-2 weeks) versus late stages (6-7 weeks) of CRC development in different colon compartments (tumor, epithelium, lamina propria), as well as in colon-draining lymph nodes and the liver as potential metastasis sites. To achieve this, we injected by colonoscopy tumor AKP mouse organoids (mutations in APC, Kras, and P53 genes) or metastatic AKP mouse organoids in the colon walls of a novel fate-mapping strain (iSell-tomato). This model allows for the labelling of peripheral T cells that are recruited to the tissue or tumor sites. Our initial data showed an enhanced recruitment of CD4 and CD8ab T cells to the colon epithelium in early stage AKP (non-metastatic) tumor models compared to late-stage AKP and metastatic-AKP models at both stages. These recruited cells exhibited an enhanced anti-tumorigenic profile characterized by the production of IFNg and reduced frequency of FoxP3+ CD4 regulatory T cells (Tregs). In contrast, T cells recruited to early stage metastatic-AKP tumors and late-stage tumors of the colon and liver exhibited enhanced exhaustion characterized by an increased frequency of PD1+ CD4 and CD8ab T cells. These data suggest a time- and aggressiveness-dependent effect of tumors on immune cell infiltrates that, in turn, affect tumor progression and metastasis.
Citation Format: Marwa A Saad, Angelina Bilate, Daniel Mucida. T cell recruitment dynamics at different stages of primary and metastatic colorectal cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr B039.
Abstract IA015: Obesity and immunometabolism in cancer immunotherapy
Authors: Rathmell Jeffrey 
Published: December 2023

Abstract
Obesity is increasing in prevalence and contributes to approximately 1 million new cancer cases annually. The effects of obesity and altered metabolism on cancers and anti-tumor immunity, remain poorly understood. The metabolism of T cells and other immune cells is dynamically regulated through growth signals and microenvironmental cues to influence biosynthesis, signaling, and cell fate. We have shown that CD4 T cell subsets are metabolically distinct and that each requires a specific metabolic program for their function. To address how cell-extrinsic factors in obesity regulate immunotherapy responses we have studied obesity and fever temperatures as regulators of immune cell metabolism and fate. Obesity is associated with increased risk of cancer but can paradoxically enhance the efficacy of immune therapy in some cases. We found this effect is in part mediated by the adipokine Leptin, which is elevated in obesity and can stimulate T cells. In addition, tumors in obese individuals and animals have increased frequencies of PD-1+ macrophages. We tested the role of PD-1 on macrophages and show with inhibitors and genetic knockouts that it is a direct regulator of macrophage metabolism and suppresses ability to of macrophages to phagocytose and present antigen and stimulate T cells. Macrophages induced PD-1 in response to multiple inflammatory cytokines, but also upon exposure to lipids or with Leptin or Insulin. PD-1-deficient macrophages had increased glycolysis and ability to stimulate T cells. These data show that obesity both promotes inflammation through adipokines such as Leptin, while simultaneously inhibiting anti-tumor immunity through induction of PD-1 on macrophages.
Citation Format: Jeffrey Rathmell. Obesity and immunometabolism in cancer immunotherapy [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr IA015.
Abstract PR06: Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division
Authors: Philip Mary , Rudloff Michael W. , Zumbo Paul , Betel Doron , Favret Natalie R. , Roetman Jessica J. , Roman Carlos R. Detres , Erwin Megan M. , Murray Kristen A. , Jonnakuti Sriya T. , Dundar Friederike 
Published: December 2023

Abstract
Tumor-specific CD8 T cells (TST) found in patients with cancer are dysfunctional and unable to halt cancer progressions. TST dysfunction, also known as T cell exhaustion, is thought to be driven by chronic T cell receptor/antigen stimulation and immunosuppressive factors within the tumor microenvironment. However, we know little about the interplay between CD8 T cell function, cell division, and epigenetic remodeling during the first hours following activation and tumor encounter. Here, we assessed TST differentiation, cell division, chromatin accessibility, and transcription in two clinically-relevant cancer mouse models (autochthonous liver cancer and metastatic melanoma), and we compared TST fate trajectories to those of CD8 T cells differentiating during acute infection. Surprisingly, despite robust activation and proliferation, TST had near complete effector function impairment even prior to undergoing cell division, and had acquired hallmark chromatin accessibility features previously observed in late dysfunctional/exhausted T cells. Moreover, continued tumor/antigen exposure drove progressive epigenetic remodeling, “imprinting” the dysfunctional state. Our study defines for the first time the regulation and kinetics underlying T cell fate choice prior to cell division in the context of tumors versus infection.
Citation Format: Mary Philip, Michael W. Rudloff, Paul Zumbo, Doron Betel, Natalie R. Favret, Jessica J. Roetman, Carlos R. Detres Roman, Megan M. Erwin, Kristen A. Murray, Sriya T. Jonnakuti, Friederike Dundar. Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr PR06.
Intensive Versus Traditional Cardiac Rehabilitation: Mortality and Cardiovascular Outcomes in a 2016–2020 Retrospective Medicare Cohort
Authors: Husaini Mustafa , Deych Elena , Waken R.J. , Sells Blake , Lai Andrew , Racette Susan B. , Rich Michael W. , Joynt Maddox Karen E. , Peterson Linda R. 
Published: December 2023

BACKGROUND:
Traditional cardiac rehabilitation (CR) improves cardiovascular outcomes and reduces mortality, but less is known about the relative benefit of intensive CR (ICR) which incorporates greater lifestyle education through 72 sessions (versus 36 in CR). Our objective was to determine whether ICR is associated with a mortality and cardiovascular benefit compared with CR.

METHODS:
Retrospective cohort study of Medicare Fee-For-Service beneficiaries in a 100% sample, claims data set. Qualifying events were captured from May 1, 2016 to December 31, 2019 and ICR/CR utilization captured from May 1, 2016 to December 31, 2020. Among patients attending at least 1 day of either CR or ICR, Cox proportional hazards models using a 1 to 5 propensity score match were used to compare utilization and the association of ICR versus CR participation with (1) all-cause mortality and (2) cardiovascular-related hospitalizations or nonfatal cardiac events. Dose-response was assessed by the number of days attended.

RESULTS:

From 2016 to 2019, 1 277 358 unique patients met at least one qualifying indication for ICR/CR from 2016 to 2019. Of these, 262 579 (20.6%) and 4452 (0.4%) attended at least one session of CR or ICR, respectively (mean [SD] age, 73.2 [7.8] years; 32.3% female). In the matched sample, including 26 659 total patients (median, 2.4-year follow-up), ICR was associated with 12% lower all-cause mortality (multivariable adjusted hazard ratio, 0.88 [95% CI, 0.78–0.99];
P
=0.036) compared with CR but no significant difference for cardiovascular-related hospitalization or nonfatal cardiac events. The mortality benefit was seen for both ICR and CR per day strata, with each modality demonstrating a clear dose-response benefit.

CONCLUSIONS:
ICR is associated with lower mortality than traditional CR among Medicare beneficiaries but no difference in cardiovascular-related hospitalization or nonfatal cardiac events. Moreover, ICR and CR demonstrate a dose-response relationship for mortality. Additional studies are needed to confirm these observations and to better understand the mechanisms by which ICR may lead to a reduction in mortality.
Armenia and Iran
Authors: Cereti Carlo G. 
Published: December 2023

Abstract
This paper focuses on the worship of Anāhitā in Western Asia examining some of the ideas put forward by James R. Russel in his volume on Zoroastrianism in Armenia in the light of more recent discussions about the role played by the goddess in Armenian religion before the conversion of the country to Christianity. While the evidence from more ancient periods has also been briefly presented, specific attention is given to Anāhīd’s worship in the Sasanian period and to the devotion of Narseh to this divinity. Finally, Middle Persian personal names containing the theonym Anāhīd are briefly introduced and discussed, showing that this important divinity is underrepresented in Sasanian and post-Sasanian onomastics.
An Unknown Source on Proselytism among the Udis
Authors: Arakelova Victoria , Hakobyan Hayk 
Published: December 2023

Abstract
This paper presents the English translation with commentaries of some interesting passages from the unpublished manuscript by Abgar Payazat, an Armenian-Udi intellectual of the beginning of the 20th century. He particularly describes episodes of proselytism among the Udis from the Armenian Apostolic Church to the Russian Orthodoxy. The manuscript itself, is an attempt of compiling a grammar of the Udi language in Armenian.
Normative Framework for the Regulation of Holdout Creditors in the Sovereign Debt Market
Authors: Oluyeju Maria , Oluyeju Olufemi 
Published: December 2023

Abstract
This article challenges the contemporary negative and dismissive narratives about distressed debt hedge funds (DDHFs), a subset of holdout creditors. A soft normative framework for regulating this category of creditors and other holdout creditors is however proposed to address their disruptive activities in the sovereign debt market. It is proposed that the Basel III framework be a conduit for enforcing the proposed normative framework because hedge funds are customers of institutions subject to Basel III oversight. One of the characteristics of these funds is their relatively sophisticated and high use of leverage. The authors therefore envisage the Basel III framework being expanded to provide for enforcement in this context. Finally, the normative framework proposed in this article differs from previous proposals including the Sovereign Debt Restructuring Mechanism (SDRM) and contractual solutions including Collective Action Clauses (CACs) and exit consents as it proposes the Basel III framework as an enforcement mechanism and is not a contractual solution.
Šaraf, charité et pauvreté : aperçu d’une histoire sociale des chorfa au Maroc (années 1860-années 1930)
Authors: Perrier Antoine 
Published: December 2023

Abstract
Moroccan chorfa are presented as a group defined less by their sociology than by a common genealogy. By examining a corpus of administrative archives from the Makhzen, then from the colonial state, we aim to examine the links between šaraf and poverty, and to explore manifestations of material distress or collective generosity towards the chorfa. Without stopping at the break with the establishment of the protectorate, this article shows the chorfa’s continued privileged place in assisting the poor and the persistence of a statutory definition of the right to assistance, which has as much to do with spiritual humility as with a hereditary right to alms. This continuity illustrates the coherence of the group, despite its social heterogeneity, and its political usefulness for the Makhzen, which wished to preserve its chorfa from an indigence that was too perilous. It also shows that «poverty» in Moroccan society can never be reduced to mere material misery.
« Les Historiens des Chorfa ». Deux ouvrages généalogiques sur les chorfa marocains à l’époque contemporaine (fin XIXe siècle-fin XXe siècle)
Authors: Mayeur-Jaouen Catherine 
Published: December 2023

Abstract
During early modern period, general censuses and genealogical works on the Moroccan genealogies of the descendants of the prophets (šurafāʾ, ašrāf) were often commissioned by sultans. Printed at the very end of the nineteenth century, al-Faḍīlī’s al-Durar al-bahiyyah was written at the request of the sultan Mawlāy Hasan. It compiled previous genealogical works of the early modern period and major genealogical sources of the nineteenth century. During the twentieth century, the last major survey of ašrāf families in Morocco is Maṣābīḥ al-bašariyyah, published in 1408/1987: it significantly describes the transformation of ašrāf families into urban elites of modern Morocco and their migration to the large cities of northern Morocco. This paper will explain the methods of investigation and classification described in al-Durar al-bahiyyah and Maṣābīḥ al-bašariyyah.
Gassendi and the Dutch: From the Parhelia Affair to the Reception of the Disquisitio metaphysica
Authors: Verbeek Theo 
Published: December 2023

Abstract
The Dutch reception of Gassendi is determined on the one hand by his journey to the United Provinces in 1629 and on the other by his works as they were published from 1624 to 1656. With much of it I dealt in earlier publications. What I present here are some supplementary remarks and a closer consideration of, presumably, the last Dutch ‘Gassendist’, Gerardus de Vries (1648–1705).
Bayle on Gassendi: The History and Theory of Atomism
Authors: Collacciani Domenico 
Published: December 2023

Abstract
In this article, I explore the role that Gassendi’s philosophy plays in Pierre Bayle’s work. Bayle often quotes Gassendi, as much in the Œuvres diverses as in the Dictionnaire. Despite their stylistic differences, the two authors share a sceptical stance that is supported by considerable erudition. First, I demonstrate that Gassendi is an important source of historical information and philological observations. Second, I discuss the thesis of ensouled atoms that Bayle formulates on several occasions in his articles on ancient atomism and argue that the hypothesis constitutes a polemical stance against modern atomism. In particular, it provides grounds for a critique of the definition of the weight of atoms in the Syntagma. I suggest that according to Bayle, the notion of materia actuosa must be refuted on the grounds that it may render the generation of sentient life inconceivable.
Redefining “Core Competencies”: Labor Market Intermediation in Outsourced Warehouses
Authors: Gutelius Beth , Theodore Nik 
Published: December 2023

Abstract
For nearly a half century, questions of why and how firms navigate the “make-buy” decision have animated fields as varied as industrial relations and economic geography. The idea of “core competencies” became the dominant explanation of corporate decision-making processes, where any activity deemed outside of the central specializations of the firm is a possible candidate for outsourcing. Coupled with the focus on short-term profit taking, corporate leaders have grown increasingly focused on shedding less-profitable activities and shifting supply-chain risk—leading to high levels of lead-firm influence over subcontracting markets and the cost-based competition that permeates them. This paper examines the role of third-party logistics companies (3pl s) in the warehousing sector. It argues that efforts to contain operational costs increasingly are focused on labor and that the ability to access and deploy low-cost labor is among the “core competencies” touted by many 3pl s in the warehousing sector.
Depression and its associated factors: A comparison between congenital and acquired physical disabilities
Authors: Kim Agnus M , Park Jae-Hyun 
Published: December 2023

Objective While depression associated with disability has been extensively studied, how depression could differ depending on whether the disability is congenital or acquired remains to be investigated. The objective of this study was to compare depression and related factors among people with congenital and acquired physical disabilities. Methods We used the 2016 Panel Survey of Employment for the Disabled in Korea, a population-based survey for people with disability registered with the Korean government. Among 4577 participants, a total of 2128 participants with physical disability were analyzed using chi-square and binary logistic regression analysis. Results The prevalence of depression was 12.9% in those with congenital physical disability and 16.0% in those with acquired physical disability. Stress due to disability and family relationship satisfaction were associated with higher and lower odds of depression, respectively, in both disability groups. Discrimination due to disability, divorce, social participation, and subjective social status were significant predictors of depression only in people with acquired disability. Conclusions Compared to those with congenital disability, individuals with acquired disability can be more susceptible to issues relating to social relationships, social standing and discrimination. Findings of this study suggest that acquired disability and adapting to changes associated with it can be a source of mental distress in addition to living with it. Efforts are needed to address discrimination, provide supportive social relationships, and provide supportive living conditions in order to reduce depression in persons living with disability, especially those with acquired disability.
Between- and within-person longitudinal associations between personality traits and social support across relationships during older adulthood
Authors: Hill Patrick L , Pfund Gabrielle N , Allemand Mathias , Kivi Marie , Berg Anne Ingeborg , Thorvaldsson Valgeir , Hansson Isabelle 
Published: December 2023

The current study investigated how perceived social support was associated with personality trait development in a Swedish longitudinal sample ( n = 3914; mean age = 63.09 years) with six waves of data on individuals’ Big Five personality traits, and perceived support from family, friends, and a special someone. We employed random intercept cross-lagged panel models to consider the between- and within-person associations for these constructs over time. First, in almost all cases, between-person associations were found between the levels for personality traits and support variables. Moreover, findings did not differ much depending on the source of the relationship. Second, again in almost every model, significant within-person covariances were evidenced, suggesting that when individuals increased on support relative to their typical level at a given wave, they also tended to report higher levels than they typically do on these traits. Finally, however, little evidence was found for cross-lagged effects in either direction. Across models, only one cross-lagged association even reached significance. In sum, our findings support the close connection between personality and perceived social support in older adulthood, and they motivate future directions into when and why such associations occur using more proximal measurements.
Toward a Better Understanding of G4 Evolution in the 3 Living Kingdoms
Authors: Vannutelli Anaïs , Ouangraoua Aïda , Perreault Jean-Pierre 
Published: December 2023

Background: G-quadruplexes (G4s) are secondary structures in DNA and RNA that impact various cellular processes, such as transcription, splicing, and translation. Due to their numerous functions, G4s are involved in many diseases, making their study important. Yet, G4s evolution remains largely unknown, due to their low sequence similarity and the poor quality of their sequence alignments across several species. To address this, we designed a strategy that avoids direct G4s alignment to study G4s evolution in the 3 species kingdoms. We also explored the coevolution between RBPs and G4s. Methods: We retrieved one-to-one orthologous genes from the Ensembl Compara database and computed groups of one-to-one orthologous genes. For each group, we aligned gene sequences and identified G4 families as groups of overlapping G4s in the alignment. We analyzed these G4 families using Count, a tool to infer feature evolution into a gene or a species tree. Additionally, we utilized these G4 families to predict G4s by homology. To establish a control dataset, we performed mono-, di- and tri-nucleotide shuffling. Results: Only a few conserved G4s occur among all living kingdoms. In eukaryotes, G4s exhibit slight conservation among vertebrates, and few are conserved between plants. In archaea and bacteria, at most, only 2 G4s are common. The G4 homology-based prediction increases the number of conserved G4s in common ancestors. The coevolution between RNA-binding proteins and G4s was investigated and revealed a modest impact of RNA-binding proteins evolution on G4 evolution. However, the details of this relationship remain unclear. Conclusion: Even if G4 evolution still eludes us, the present study provides key information to compute groups of homologous G4 and to reveal the evolution history of G4 families.