bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prognostic signature based on snoRNA predicts the overall survival of lower-grade glioma patients
Authors: Zhou Yi , Yin Wen , Kuang Yirui , Wu Zhaoping , Huang Haoxuan , Liu Weidong , Jiang Xingjun , Ren Caiping 
Published: November 2023

IntroductionSmall nucleolar RNAs (snoRNAs) are a group of non-coding RNAs enriched in the nucleus which direct post-transcriptional modifications of rRNAs, snRNAs and other molecules. Recent studies have suggested that snoRNAs have a significant role in tumor oncogenesis and can be served as prognostic markers for predicting the overall survival of tumor patients. MethodsWe screened 122 survival-related snoRNAs from public databases and eventually selected 7 snoRNAs that were most relevant to the prognosis of lower-grade glioma (LGG) patients for the establishment of the 7-snoRNA prognostic signature. Further, we combined clinical characteristics related to the prognosis of glioma patients and the 7-snoRNA prognostic signature to construct a nomogram.ResultsThe prognostic model displayed greater predictive power in both validation set and stratification analysis. Results of enrichment analysis revealed that these snoRNAs mainly participated in the post-transcriptional process such as RNA splicing, metabolism and modifications. In addition, 7-snoRNA prognostic signature were positively correlated with immune scores and expression levels of multiple immune checkpoint molecules, which can be used as potential biomarkers for immunotherapy prediction. From the results of bioinformatics analysis, we inferred that SNORD88C has a major role in the development of glioma, and then performed in vitro experiments to validate it. The results revealed that SNORD88C could promote the proliferation, invasion and migration of glioma cells. DiscussionWe established a 7-snoRNA prognostic signature and nomogram that can be applied to evaluate the survival of LGG patients with good sensitivity and specificity. In addition, SNORD88C could promote the proliferation, migration and invasion of glioma cells and is involved in a variety of biological processes related to DNA and RNA.
Investigation of Impregnation Approach of Zinc Oxide Nano-Dispersions for Potential UV Stabilization in Abies alba and Fagus sylvatica
Authors: Sommerauer Lukas , Petutschnigg Alexander , Schnabel Thomas 
Published: November 2023

As biological material, wood is distinctly affected by to various environmental influences during use. Reductions in durability can come from ultraviolet (UV) radiation, insects, fungi, and microorganisms in both exterior and interior applications. Wood can be easily protected from living organisms via the control of moisture content; however, UV radiation is not so easily managed. Wood components subject to this degradation are damaged and decomposed at a molecular level leading to deterioration of surface quality, especially in visible application areas. A potential remedy to this is using the UV-stabilizing properties of zinc oxide nanoparticles. Zinc oxide nano-dispersions based on propylene glycol (PG) were introduced into the microscopic structure of fir (Abies alba) and beech (Fagus sylvatica) wood by whole-cell impregnation to overcome problems associated with surface coatings. In this work the material uptake of ZnO nano-dispersions in concentrations of 1%, 2%, and 3% w/v were investigated and their effect on the stability of the optical appearance to UV exposure in short-term weathering were evaluated. Untreated reference samples showed significant photo-yellowing. A 1% w/v ZnO dispersion significantly increased the UV stability of treated surfaces. It was found that the uptake of the nano-dispersions was independent of the proportion of ZnO, and that the impregnating agents penetrated fir wood (about 200%) stronger than beech wood (about 70%). Already, a 2% w/v ZnO nano-dispersion led to a saturation of ZnO in the cell structure of the treated wood, for fir as well as beech, and no further ZnO uptake was achieved with 3% w/v nano-dispersions. Scanning electron microscopy shows an agglomeration of ZnO-NP in the cellular pathways impacting penetration, reducing leachability at higher concentrations.
Patient experiences of the Long COVID–Optimal Health Programme: a qualitative interview study in community settings
Authors: Al-Jabr Hiyam , Windle Karen , Clifton Andrew , Thompson David R , Castle David J , Ski Chantal F 
Published: November 2023

BackgroundLong COVID (LC) symptoms persist 12 weeks or more beyond the acute infection. To date, no standardised diagnostic or treatment pathways exist. However, a holistic approach has been recommended. This study explored participants’ experiences of a Long COVID–Optimal Health Programme (LC–OHP); a psychoeducational self-efficacy programme.AimTo explore perceptions and experiences of people with LC regarding the LC-OHP and identify suggestions to further improve the programme.Design & settingQualitative study with patients with LC recruited through community settings.MethodThis study is part of a wider randomised controlled trial. Eligible participants were aged ≥18 years, have LC, and attended a minimum of five LC–OHP sessions plus a booster session. We interviewed those randomised to the intervention group. Interviews were conducted by an independent researcher and thematically analysed to identify common, emerging themes.ResultsEleven participants were interviewed, mostly women from a White British ethnic group (n= 10). Four main themes were identified, reflecting programme benefits and suggestions for improvement. The programme demonstrated potential for assisting patients in managing their LC, including physical health and mental wellbeing. Participants found the programme to be flexible and provided suggestions to adapting it for future users.ConclusionFindings support the acceptability of the LC–OHP to people living with LC. The programme has shown several benefits in supporting physical health and mental wellbeing. Suggestions made to further adapt the programme and improve its delivery will be considered for future trials.
La galère : Jeunes en survie
Authors: Dubet François 
Published: November 2023

Cet ouvrage repose sur des entretiens approfondis entre des groupes de jeunes de quartiers difficiles (à Seraing, Venissieux, Orly, Sartrouville, Champigny et Clichy) et des équipes de sociologues et d’intervenants sociaux. Il analyse de façon assez sombre l'univers de galère de ces jeunes.
Le passage, extrait du chapitre XVI, que nous reproduisons ici avec l'aimable autorisation de l’éditeur, traite plus précisément des jeunes issus de l'immigration dans le cadre de la cité des Minguettes à Venissieux et introduit une note plus positive. Les jeunes immigrés, s'ils sont plus enfoncés dans la galère que les jeunes Français, manifestent par ailleurs de plus grandes capacités de renverser les logiques de celle-ci. Quant au racisme il semble absent des relations entre les jeunes eux-mêmes.
Pour une pédagogie interculturelle de la francophonie
Authors: Porcher Louis 
Published: November 2023

Les pédagogues sont particulièrement concernés par ce phénomène de géopolitique linguistique et culturelle qu’est la francophonie.
Celle-ci fournit un cadre incomparable pour proposer à la pédagogie la double figure majeure de l’interculturel : le partage des cultures et l’enracinement des identités.
Penser l’échec comme événement, penser l’immigration comme histoire
Authors: Charlot Bernard 
Published: November 2023

La notion de handicap socioculturel, au centre des débats dans les années 70, réduit trop l’individu au groupe et les rapports sociaux à des rapports spaciaux.
De même l’idée d’enfant biculturel enferme l’enfant d’immigrés dans des catégories figées.
Plus encore que celle des autres enfants, la scolarité des enfants d’immigrés doit être pensée en termes de processus, de trajectoires, comme une expérience personnelle et sociale qui a une histoire.
Les filles de la nouvelle génération africaine. Continuité ou rupture ?
Authors: Nicollet Albert 
Published: November 2023

L'appartenance culturelle africaine se transmet-elle dans les générations nouvelles ou est-elle destinée à s'effacer devant une «francisation » massive ?
Une première étude du comportement des adolescentes africaines : vêtements et coiffure, fréquentations et sorties, attitudes devant la sexualité et le mariage, relations avec les parents et avec l'école…
Les Antillais, la citoyenneté et l’école : les conditions de l'intégration
Authors: Galap Jean 
Published: November 2023

L’échec scolaire des enfants antillais en Métropole, en dehors des facteurs liés à l'origine sociale, a deux causes essentielles : la mauvaise connaissance que le système éducatif a de cette population et une totale inorganisation communautaire qui ne permet pas à la famille de transmettre à l'enfant une image de soi positive et équilibrante.
La reconnaissance de l'identité de l’enfant antillais, dans un contexte ouvert et évolutif, n'est pas en contradiction avec le modèle républicain d’intégration.
Tiers lieu éducatif et accompagnement scolaire
Authors: Coq Guy 
Published: November 2023

L'une des fonctions du tiers lieu éducatif est d'assurer un rééquilibrage quand l'école ou la famille défaille, quand le rapport entre les deux se dégrade.
La coexistence et le dialogue entre les trois instances, dans la claire distinction des fonctions de chacune d'elles, est une des conditions de la liberté de l'enfant.
L'accompagnement scolaire, étude permanente des problèmes de certains enfants dans l'école, peut contribuer à améliorer les pratiques pédagogiques de celle-là à condition que les moniteurs soient incités par la formation à adopter une attitude constructive et positive vis-à-vis de l'école.
A Nef Precursor or Benign Counterpart: High Prevalence of Healthy Subjects with Antibody Reactivity to the C3-Convertase
Authors: Culek Christopher T. , Nester Carla M. 
Published: November 2023

Key Points

There are two anticonvertase antibody populations—Nephritic Factors which cause complement dysregulation and C3CAbs which do not.C3CAbs are highly prevalent in the healthy adult population (>95% prevalence).C3CAbs suggest a direction of study to determine the origin of Nephritic Factors.
Perfil epidemiológico dos casos de Sífilis Congênita notificados no município de Teresina – Piauí, no período de 2012 a 2022
Authors: Almada Alanna Gabryele Cruz , De Sousa Isabel Neci , Silva Mariane Costa , Castro Neto Raimundo Nonato Sousa , Bezerra Yuri Francisco , De Araujo Liliam Mendes , Araújo Adriana Sávia de Souza 
Published: November 2023

Introdução: a sífilis é uma infecção crônica cuja transmissão ocorre principalmente através do contato sexual, podendo acontecer a transmissão vertical caso a gestante não seja tratada ou realizar tratamento inadequado. Objetivo: analisar o perfil epidemiológico dos casos de Sífilis Congênita (SC) notificados no município de Teresina – Piauí, no período de 2012 a 2022. Método: tratou-se de um estudo epidemiológico, quantitativo, do tipo descritivo e retrospectivo que analisou o perfil epidemiológico dos casos de SC, notificados na capital, nos anos de 2012 a 2022. Resultados: no período analisado foram notificados 1445 casos de sífilis congênita, com maior incidência nos anos de 2015 e 2018 e taxa anual média de 15,43/1.000 nascidos vivos; 88,6% dos casos de SC foram diagnosticados nos primeiros seis dias após o nascimento; predominância de mães com idade entre 20 e 29 anos, ensino fundamental incompleto e pardas, 78,4% realizaram o pré-natal e apenas 2,9% fizeram o tratamento adequado da sífilis. Conclusão: os resultados demonstram que a sífilis persiste como problema de saúde pública e o controle da SC no município em questão está deficiente, fazendo-se necessário implementar medidas de qualificação na rede de assistência pré-natal.
PERBANDINGAN KADAR TIMBAL (Pb) DALAM URIN METODE AAS MENGGUNAKAN DESTRUKSI BASAH TERBUKA DAN TERTUTUP DENGAN VARIASI ZAT PENGOKSIDASI
Authors: Suci Romadani Faizal 
Published: November 2023

Kontaminasi timbal akan menimbulkan dampak negatif jika masuk kedalam tubuh dalam jumlah yang berlebihan yang dapat merugikan tubuh. Salah satu orang yang berisiko terkena kontaminasi timbal yaitu pengepul sampah, pada TPS banyak sampah B2 rumah tangga khususnya yang mengandung timbal (Pb) sehingga terkena kontaminasi langsung sampah B2 Penelitian ini bertujuan untuk mengetahui perlakuan yang paling efektif antara destruksi basah secara terbuka atau tertutup dan mengetahui larutan pendestruksi terbaik dalam pemeriksaaan kadar timbal pada urin petugas sampah. Penelitian ini merupakan penelitian eksperimental dengan rancangan posttest only design yang dilakukan di Laboratorium Kesehatan Daerah Jl. Gayungsari Barat No. 124 Surabaya. Bahan uji dalam penelitian ini adalah urin petugas sampah. Sampel penelitian bersifat purposive sampling. Penetuan kadar timbal dilakukan dengan alat AAS (Atomic Absorption Spectrophotometry). Sampel harus berupa larutan yang jernih sehingga dilakukan preparasi. Terdapat dua cara preparasi sampel yang dapat dilakukan dalam analisis Pb pada urin yaitu proses destruksi basah secara terbuka dan tertutup dengan menggunakan zat pengoksidasi Asam Nitrat (HNO3), Asam Sulfat (H2SO4) dan Hidrogen Peroksida (H2O2). Hasil pengukuran rata – rata kadar timbal pada destruksi basah secara terbuka dengan zat pengoksidasi HNO3 dan H2SO4 (3:1) yaitu 0,4348 mg/L dan zat pengoksidasi HNO3, H2SO4 dan H2O2 (6:2:1) yaitu 0,4138 mg/L, rata – rata kadar Pb dalam destruksi basah secara tertutup dengan zat pengoksidasi HNO3 dan H2SO4 (3:1) yaitu 0,4018 mg/L dan destruksi basah secara tertutup dengan zat pengoksidasi HNO3, H2SO4 dan H2O2 (6:2:1) yaitu 0,3897 mg/L.
INOVASI PEMANFAATAN TEPUNG DAGING BACKLOIN IKAN CAKALANG (Katsuwonus pelamis) SEBAGAI MEDIA SUBTITUSI NUTRIENT AGAR PADA PERTUMBUHAN Staphylococcus aureus DAN Escherichia coli
Authors: Niam Zainatun 
Published: November 2023

Ikan Cakalang menjadi salah satu komoditas ekspor baik dalam bentuk beku, olahan, maupun segar. Ikan ini sangat diminati masyarakat karena memiliki kandungan protein yang tinggi, tekstur daging yang baik dan cita rasa yang tinggi sehingga, peneliti berinovasi untuk memanfaatkan Ikan Cakalang bukan hanya untuk dikonsumsi, melainkan dapat digunakan sebagai bahan dasar pembuatan media pertumbuhan bakteri. Ikan Cakalang mengandung gizi yang cukup tinggi diantaranya yaitu kadar air 4.56%, protein 38.12%, lemak 17.46%, kadar abu 0.79%. Tujuan penelitian ini untuk mengetahui kemampuan media tepung backloin Ikan Cakalang terhadap pertumbuhan Eschericia coli dan Staphylococcus aureus yang ditinjau dari segi jumlah dan karakteristik bakteri. Penelitian ini dilakukan pada bulan April 2021 di Laboratorium Bakteriologi Poltekkes Surabaya Jurusan Teknologi Laboratorium Medis. Jenis Penelitian ini adalah Eksperimental Laboratoris. Rancangan penelitian ini adalah pretest-posttest control group design dengan variasi massa tepung Ikan Cakalang adalah 1 gram, 1.5 gram, 2 gram, 2.5 gram, dan 3 gram serta gold standard media yang digunakan adalah Nutrient Agar yang direplikasi sebanyak 5 kali. Proses inokulasi bakteri dilakukan dengan menggunakan metode spread plate. Hasil penelitian ini menunjukan jumlah rata-rata koloni terbanyak pada media tepung daging backloin Ikan Cakalang sebanyak 190,2x 1013 CFU/mL dengan variasi massa 3 gram pada Staphylococcus aureus, sedangkan jumlah rata-rata terbanyak pada pertumbuhan Escherichia coli yaitu pada variasi massa 2.5 gram yaitu 160 x 1013 CFU/mL. Jumlah koloni yang berfariasi disebabkan karena kandungan nutrisi pada tepung daging Ikan Cakalang ini lebih kompleks dibandingkan dengan kandungan nutrisi pada media Nutrient Agar.
Deflection of Coronal Mass Ejections in Unipolar Ambient Magnetic Fields
Authors: Ben-Nun Michal , Török Tibor , Palmerio Erika , Downs Cooper , Titov Viacheslav S. , Linton Mark G. , Caplan Ronald M. , Lionello Roberto 
Published: November 2023

Abstract
The trajectories of coronal mass ejections (CMEs) are often seen to deviate substantially from a purely radial propagation direction. Such deviations occur predominantly in the corona and have been attributed to “channeling” or deflection of the eruptive flux by asymmetric ambient magnetic fields. Here, we investigate an additional mechanism that does not require any asymmetry of the preeruptive ambient field. Using magnetohydrodynamic numerical simulations, we show that the trajectories of CMEs through the solar corona can significantly deviate from the radial direction when propagation takes place in a unipolar radial field. We demonstrate that the deviation is most prominent below ∼15 R
⊙ and can be attributed to an “effective
I
×
B
force” that arises from the intrusion of a magnetic flux rope with a net axial electric current into a unipolar background field. These results are important for predictions of CME trajectories in the context of space-weather forecasts, as well as for reaching a deeper understanding of the fundamental physics underlying CME interactions with the ambient fields in the extended solar corona.
PEARLS: Near-infrared Photometry in the JWST North Ecliptic Pole Time Domain Field*
Authors: Willmer Christopher N. A. , Ly Chun , Kikuta Satoshi , Kattner S. A. , Jansen Rolf A. , Cohen Seth H. , Windhorst Rogier A. , Smail Ian , Tompkins Scott , Beacom John F. , Cheng Cheng , Conselice Christopher J. , Frye Brenda L. , Koekemoer Anton M. , Hathi Nimish , Hyun Minhee , Im Myungshin , Willner S. P. , Zhao X. , Brisken Walter A. , Civano F. , Cotton William , Hasinger Günther , Maksym W. Peter , Rieke Marcia J. , Grogin Norman A. 
Published: November 2023

Abstract
We present near-infrared (NIR) ground-based Y, J, H, and K imaging obtained in the James Webb Space Telescope (JWST) North Ecliptic Pole Time Domain Field (NEP TDF) using the MMT-Magellan Infrared Imager and Spectrometer on the MMT. These new observations cover a field of approximately 230 arcmin2 in Y, H, and K, and 313 arcmin2 in J. Using Monte Carlo simulations, we estimate a 1σ depth relative to the background sky of (Y, J, H, K) = (23.80, 23.53, 23.13, 23.28) in AB magnitudes for point sources at a 95% completeness level. These observations are part of the ground-based effort to characterize this region of the sky, supplementing space-based data obtained with Chandra, NuSTAR, XMM, AstroSat, Hubble Space Telescope, and JWST. This paper describes the observations and reduction of the NIR imaging and combines these NIR data with archival imaging in the visible, obtained with the Subaru Hyper-Suprime-Cam, to produce a merged catalog of 57,501 sources. The new observations reported here, plus the corresponding multiwavelength catalog, will provide a baseline for time-domain studies of bright sources in the NEP TDF.
The Novel OMERACT Ultrasound Scoring System for Salivary Gland Changes in Patients With Sjögren Syndrome Is Associated With MRI and Salivary Flow Rates
Authors: Inanc Nevsun , Jousse-Joulin Sandrine , Abacar Kerem , Cimşit Çagatay , Cimşit Canan , D’Agostino Maria-Antonietta , Naredo Esperanza , Hocevar Alojzija , Finzel Stephanie , Pineda Carlos , Keen Helen , Iagnocco Annamaria , Hanova Petra , Schmidt Wolfgang A. , Mumcu Gonca , Terslev Lene , Bruyn George A. 
Published: November 2023

ObjectiveTo assess the construct validity of the novel Outcome Measures in Rheumatology (OMERACT) ultrasound (US) semiquantitative scoring system for morphological lesions in major salivary glands by comparing it with magnetic resonance imaging (MRI) and unstimulated whole salivary flow rates (U-WSFRs) in patients with primary Sjögren syndrome (pSS).MethodsNine sonographers applied the OMERACT 0-3 grayscale scoring system for parotid (PGs) and submandibular glands (SMGs) in 11 patients with pSS who also had MRIs performed. These were evaluated by 2 radiologists using a semiquantitative 0-3 scoring system for morphological lesions. The agreement between US and MRI and the association between U-WSFRs and imaging structural lesions was determined. A score ≥ 2 for both US and MRI was defined as gland pathology.ResultsThe prevalence of US morphological lesions in 11 patients with a score ≥ 2 was 58% for PGs and 76% for SMGs, and 46% and 41% for PGs and SMGs, respectively, for MRI. The agreement between OMERACT US scores and MRI scores was 73-91% (median 82%) in the right PG and 73-91% (median 91%) in the left PG, 55-91% (median 55%) in the right SMG and 55-82% (median 55%) in the left SMG. When relations between the presence of hyposalivation and an US score ≥ 2 were examined, agreement was 91-100% (median 83%) in both PGs and 55-91% (median 67%) in both SMGs.ConclusionThere is moderate to strong agreement between the OMERACT US and MRI scores for major salivary glands in patients with pSS. Similar agreement ratios were observed between the higher OMERACT US scores and presence of hyposalivation.
Effect of Attending Rheumatologists’ Big 5 Personality Traits on Patient Trust in Patients With Systemic Lupus Erythematosus: The TRUMP2-SLE Project
Authors: Oguro Nao , Yajima Nobuyuki , Ishikawa Yuichi , Sakurai Natsuki , Hidekawa Chiharu , Ichikawa Takanori , Kishida Dai , Hayashi Keigo , Shidahara Kenta , Miyawaki Yoshia , Yoshimi Ryusuke , Sada Ken-ei , Shimojima Yasuhiro , Kurita Noriaki 
Published: November 2023

ObjectiveDifferences in communication styles based on physicians’ personality traits have been identified, particularly in primary care, and these physician-related factors can be important in building patient-physician trust. This study examined the effects of rheumatologists’ personality traits on patients’ trust in their attending rheumatologists.MethodsThis cross-sectional study included adult Japanese patients with systemic lupus erythematosus (SLE) at 5 academic medical centers between June 2020 and August 2021. The exposures were the Big 5 personality traits (ie, extraversion, agreeableness, openness, conscientiousness, and emotional stability) of attending rheumatologists using the Japanese version of the 10-Item Personality Inventory scale (1-7 points each). The outcome was the patients’ trust in their attending rheumatologist using the Japanese version of the 5-item Wake Forest Physician Trust Scale (0-100 points). A general linear model was fitted.ResultsThe study included 505 patients with a mean age of 46.8 years; 88.1% were women. Forty-three attending rheumatologists (mean age: 39.6 years; 23.3% female) were identified. After multivariable adjustment, higher extraversion and agreeableness were associated with higher trust (per 1-point increase, 3.76 points [95% CI 1.07-6.45] and 4.49 points [95% CI 1.74-7.24], respectively), and higher conscientiousness was associated with lower trust (per 1-point increase, −2.17 points [95% CI −3.31 to −1.03]).ConclusionWhereas higher extraversion and agreeableness of attending rheumatologists led to higher patient trust in their rheumatologist, overly high conscientiousness may lead to lower trust resulting from the physicians’ demand of responsibility and adherence to instructions from patients with SLE.