bluuebunny/crossref_metadata_2025_split huggingface dataset:
2018 Leibovich prognostic model for renal cell carcinoma: Performance in a large population with special consideration of Black race
Authors: Schmeusser Benjamin N. , Patil Dattatraya H. , Nicaise Edouard H. , Armas‐Phan Manuel , Nabavizadeh Reza , Narayan Vikram M. , Joshi Shreyas S. , Ogan Kenneth , Osunkoya Adeboye O. , Bilen Mehmet A. , Master Viraj A. 
Published: October 2023

AbstractBackgroundThe 2018 Leibovich prognostic model for nonmetastatic renal cell carcinoma (RCC) combines clinical, surgical, and pathologic factors to predict progression‐free survival (PFS) and cancer‐specific survival (CSS) for patients with clear cell (ccRCC), papillary (pRCC), and chromophobe (chRCC) histology. Despite high accuracy, <1% of the original cohort was Black. Here, the authors examined this model in a large population with greater Black patient representation.MethodsBy using a prospectively maintained RCC institutional database, patients were assigned Leibovich model risk scores. Survival outcomes included 5‐year and 10‐year PFS and CSS. Prognostic accuracy was determined using area under the curve (AUC) analysis and calibration plots. Black patient subanalyses were conducted.ResultsIn total, 657 (29%) of 2295 patients analyzed identified as Black. Declines in PFS and CSS were observed as scores increased. Discrimination for ccRCC was strong for PFS (AUC: 5‐year PFS, 0.81; 10‐year PFS, 0.78) and for CSS (AUC: 5‐year CSS, 0.82; 10‐year CSS, 0.74). The pRCC AUC for PFS was 0.74 at 5 years and 0.71 at 10 years; and the AUC for CSS was 0.74 at 5 years and 0.70 at 10 years. In chRCC, better performance was observed for CSS (AUC at 5 years, 0.75) than for PFS (AUC: 0.66 at 5 years; 0.55 at 10 years). Black patient subanalysis revealed similar‐to‐improved performance for ccRCC at 5 years (AUC: PFS, 0.79; CSS, 0.87). For pRCC, performance was lower for PFS (AUC at 5 years, 0.63) and was similar for CSS (AUC at 5 years, 0.77). Sample size limited Black patient 10‐year and chRCC analyses.ConclusionsThe authors externally validated the 2018 Leibovich RCC prognostic model and found optimal performance for ccRCC, followed by pRCC, and then chRCC. Importantly, the results were consistent in this large representation of Black patients.Plain Language Summary

In 2018, a model to predict survival in patients with renal cell carcinoma (kidney cancer) was introduced by Leibovich et al.
This model has performed well; however, Black patients have been under‐represented in examination of its performance.
In this study, 657 Black patients (29%) were included, and the results were consistent.
This work is important for making sure the model can be applied to all patient populations.
A hybrid machine learning algorithm for studying magnetized nanofluid flow containing gyrotactic microorganisms via a vertically inclined stretching surface
Authors: Chandra Priyanka , Das Raja 
Published: October 2023

AbstractThe novelty of the present work is to acquire continuous functions as solutions rather than the discrete ones that traditional numerical methods generally produce and to minimize simulation times and higher computation costs that are the fundamental barriers to employing any numerical method. In this study, a novel hybrid finite element‐based machine learning algorithm utilizing the Levenberg–Marquardt scheme with backpropagation in a neural network (LMBNN) is presented to analyze the nanofluid flow in the presence of magnetohydrodynamics and gyrotactic microorganisms through a vertically inclined stretching surface in a porous medium. Finite Element Method is used to generate the minimum reference dataset for LMBNN by varying six flow parameters in the form of six scenarios. Surface plots are utilized to understand how these scenarios affect velocity, temperature, concentration of nanoparticles, and density of motile microorganisms. Regression analysis, error histogram analysis, and fitness curves based on mean square error all support the LMBNN's effectiveness and dependability. Results reveal that temperature increases with the rise in Brownian motion and thermophoresis parameter, whereas the reverse trend has been noticed for Prandtl number. The motile microorganism density number decreases with the rise in Prandtl numbers but improves with the porosity parameter.
Recent Advances in Platinum Group Metal Based Alloys for Alkaline Hydrogen Oxidation Reaction
Authors: Ma Xiaolong , Zhang Shuang , Zhou Yaojiang , Lei Wenli , Zhao Pingping , Zhao Yuanmeng , Luo Wei 
Published: October 2023

AbstractThe development of efficient electrocatalysts for alkaline hydrogen oxidation reaction (HOR) is crucial to realize the commercialized application of alkaline exchange membrane fuel cells. Platinum group metals (PGMs) have been extensively used as alkaline HOR catalysts because they exhibit high activity and stability. Currently, searching for methods to improve the catalytic activity and reduce the loading of PGMs is the main research interest of PGM‐based electrocatalysts. The alloying method has been regarded as an effective strategy. In this review, we summarized various kinds of PGM‐based alloys, including traditional random alloys, single‐atom alloys, high‐entropy alloys and intermetallic compounds, and highlighted the challenges and future directions regarding the development of advanced PGM‐based alloys.
Efficient Auto‐scaling for Host Load Prediction through VM migration in Cloud
Authors: Verma Shveta , Bala Anju 
Published: October 2023

SummaryThe expeditious deployment of Cloud applications and services on wide‐ranging Cloud Data Centres (CDC) gives rise to the utilization of many resources. Moreover, by the increase in resource utilization, virtualization also greatly impacts achieving desired performance. The major challenges in virtualization are detecting over‐utilized or under‐utilized hosts at the right time and the proper scaling of Virtual Machines (VM) on the accurate host. Auto‐scaling in Cloud Computing allows the service providers to scale up or down the resources automatically and provides on‐demand computing power and storage capacities. Effective utilization and autonomous scaling of resources eventually reduce the load, energy consumption, and operating costs. In this paper, an efficient auto‐scaling approach for predicting host load through VM migration has been proposed. The ensemble method using different time‐series forecasting models has been proposed to forecast the approaching workload on the host. Based on this predicted load, different algorithms have been devised to detect over‐utilized and under‐utilized hosts and VMs can be migrated. The designed approach has been validated by experimentation on a real‐time Google cluster dataset. The proposed technique significantly improves average CPU utilization and reduces over‐utilization and under‐utilization. It also minimizes response time, service level agreement violations, and the slighter number of migrations and scaling overhead.
Techno‐economic study for the implementation of electric buses for sustainable urban and interurban transportation
Authors: Abdelouahed Ahmed , Berrada Asmae , El Mrabet Rachid 
Published: October 2023

AbstractA cleaner transportation sector requires the implementation of a variety of measures, such as the use of electric vehicles. Electric mobility has seen increasing use in public transportation, even though it still faces significant challenges. Electric bus fleets require high‐performance batteries to minimize the cost and weight of the buses. This paper investigates the energy consumption of an electric bus in urban and interurban transit using two methods: forward‐facing and backward‐facing approaches. The obtained findings have shown that the energy consumption of a bus depends on the road and its characteristics, ranging between 0.98 and 1.39 kWh/km. Furthermore, a regenerative braking analysis has been performed, and it has been found that this factor plays a significant role in reducing energy consumption by 21%. Finally, a life cycle assessment and an environmental analysis have been conducted. The obtained results have shown that the total cost of ownership of the buses in this project will be around 1.76 $/km. The use of electric buses could eliminate the greenhouse gas emissions produced by public transportation in the investigated province.
Adsorptive elimination of methylene blue dye from aqueous solution by chitosan‐nSiO2 nanocomposite: Adsorption and desorption study, scale‐up design, statistical, and genetic algorithm modeling
Authors: Bhattacharya Samanwita , Bar Nirjhar , Rajbansi Baisali , Das Sudip Kumar 
Published: October 2023

AbstractHeavy metals and organic dyes in water in concentrations exceeding the tolerable limit are unsafe for aquatic life and humans. Chitosan nanocomposites show a potential adsorption capacity to organic dyes. The present study encompasses the preparation of chitosan‐nSiO2 nanocomposites (CSNC) with different weight ratios of chitosan to nSiO2 and its application in the methylene blue (MB) dye adsorption. The nanocomposites were characterized with the help of SEM, BET, FTIR, XRD, and TGA. The adsorption experimentation was executed in batch mode under varying experimental conditions. Several isotherm and kinetic models were analyzed with the experimental data, and thermodynamic conditions required for adsorption were also determined. Maximum Langmuir adsorption capacities (qL) of the adsorbents for MB varied in the range of 21.32–31.34 mg g−1. The pseudo‐second‐order model was the best‐fitted kinetic model concerning all three adsorbents. The statistical modeling using multiple polynomial regression (MPR) for CWS CSNC1‐1 and CSNC2‐1 yielded the equations with R‐square ranging from 0.984 to 0.996. For GA modeling, it is more than 0.999. So, the efficient employment of statistical modeling, and genetic algorithms has also been achieved.
Flat ball topology basics multi‐transceivers 100 km/2.5 Tbps gigabit‐ethernet PON architecture for energy efficiency in data centers
Authors: Kumari Meet , Arya Vivek 
Published: October 2023

AbstractExisting electronic data sources desire high‐power requisites, in order to obtain a large bandwidth, minimum power dissipation and low latency in networks. In this instance, a gigabit ethernet passive optical network (GEPON) architecture based on a dynamic Flat Ball topology incorporating multi‐transceivers to minimize network energy consumption via passive devices along with bandwidth reconfiguration potential and low latency is reported in this paper. The proposed architecture connected with 200 nodes exhibits 26 as well as 40 dB total loss in uplink as well as downlink considerably, compared to Sirius and Sandwich tree. Also, Flat ball GEPON architecture permits 9 and 10 dBm energy saving in downlink as well as uplink, respectively, than conventional GEPON architecture at 1 ms delay. The proposed architecture with 50 Erlang load allows energy ratio of 39% in downlink and 37% in uplink, at 25 × 100 Gbps traffic rate for 55 nodes. Besides this, the faithful fiber range of 100 km considering fiber no‐linearities and impairments can be obtained successfully. The architecture can be bordered with 1:64 splitting ratio with 35 ms in downlink as well as 31 ms in uplink transmission delay at bit error rate of 10−3. Additionally, on comparing the proposed topology with existing architectures depict its superiority with minimal implementation cost, low‐power dissipation, less traffic delay as well as high scalability and high flexibility.
Investigation of the flame properties and fire behavior of carbon‐reinforced PEKK, BMI and phenolic composites impacted by Jet‐A1/air flames
Authors: Ogabi R. , Manescau B. , Chetehouna K. , Senave S. 
Published: October 2023

AbstractThis paper provides an experimental investigation of a kerosene/air burner (the NexGen burner designed on the FAA's proposed ISO 2685 standard), which is used to generate flame/burnt gases impinging on material samples in the field of fire safety. The purpose of this study is to characterize this burner, and experimental means are implemented to better understand the effects of the equivalence ratio on the spatial distribution of the gas temperature (thermocouples), the heat flux (heat flux gauge), and gas emission species. Hence, the measured flame temperature, heat flux, and heat release rate increase up to a critical value of equivalence ratio equal to 1.03. Furthermore, a pyrolysis test was carried out on composite materials and the results of the comparative analysis of carbon‐phenolic, carbon‐BMI, and carbon‐PEKK materials show that carbon‐PEKK had the lowest mass loss, highest back‐face temperature without significant material delamination, and the lowest concentration of gas emission species.
Uncovering the complex relationships among distributed leadership, departmental teacher leadership, and professional learning community in Chinese schools
Authors: Zheng Xin , Jiang Chenxi , Liu Chenlu 
Published: October 2023

AbstractProfessional learning community (PLC) has been widely recognized as an effective approach for promoting both student learning and teacher development. Existing research on PLC mainly focuses on the school‐level, and less attention has been given to the departmental‐level PLC. Given the complex nature of school structures, departmental PLC may be influenced by multiple leadership factors, including principal and teacher leadership (TL). This study investigates how the distributed leadership (DL) of principals and TL influence departmental PLC and individual teacher self‐efficacy. Drawing on a sample of 602 teachers in China, the results showed that TL had a direct impact on teacher self‐efficacy and had an indirect effect through PLC. Additionally, the DL of principals indirectly affects individual teachers through TL and PLC. The results indicate the complex leadership structure in schools with various levels of leadership exerting distinct influences on teachers and departments. It highlights the roles of principal leadership and TL in facilitating PLC and teacher development. Implications for school leadership and PLC development are discussed.
Risk assessment of norovirus and hepatitis A virus in strawberries imported into China
Authors: Zhong Junjie , Yang Yunfeng , Zhang Hui , Zhang Shuwen , Qu Xiaosheng , Chen Qin , Niu Bing 
Published: October 2023

AbstractNorovirus (NoV) and hepatitis A virus (HAV) pose a considerable health risk worldwide. In recent years, many cases of virus infection caused by virus‐contaminated strawberries have occurred worldwide. This study applied a critical control point system to analyze the main hazards during the production and marketing of strawberries imported into China and explore the key control points in the whole process. To further evaluate the risks in the supply chain, the established quantitative microbial risk assessment (QMRA) was used to determine the probability that residents would be infected with viruses after consuming imported strawberries. It was found that the risk of virus contamination from imported strawberries was low, and the virus contamination mainly results from water resources and personnel. This research helps the regulatory authorities formulate strategies to ensure the long‐term microbial safety of imported strawberries. In addition, the methods may prove useful in evaluating the risks of other agricultural produce.
Impedance analysis of electrolyte processes in a solid oxide cell
Authors: Kullmann Felix , Grosselindemann Cedric , Salamon Luis , Fuchs Franz‐Martin , Weber André 
Published: October 2023

AbstractElectrochemical impedance spectroscopy and the distribution of relaxation times are powerful tools to study polarization processes in solid oxide cells (SOC). Commonly the measured polarization resistance is solely attributed to polarization phenomena in the electrodes whereas the electrolyte is assumed to act as purely ohmic series resistance.In this study an electrolyte supported SOC is investigated by impedance spectroscopy from the nominal operating temperature range of 700–900°C down to temperatures as low as 350°C. At such low temperatures the dielectric polarization of the electrolyte is shifted into the accessible frequency range, providing access to additional processes which are deconvoluted and quantified. It is discussed to which extent the additional layers like gadolinia doped ceria diffusion barrier and electrode layers influence the electrolyte processes as grain and grain boundary.
Neuroticism is associated with increase in depression symptoms over time in older adults with type 2 diabetes
Authors: Arend Isabel , Moshier Erin , Azuri Yossi , Heymann Anthony , Mamistavlov Mery , Soleimani Laili , Sano Mary , Beeri Michal Schnaider , Ravona‐Springer Ramit 
Published: October 2023

AbstractObjectivesThe likelihood of depression symptoms in those with type 2 diabetes (T2D) is high. Psychological risk factors enhancing comorbidity of depression symptoms in T2D are yet to be determined. The present study examines the cross‐sectional and longitudinal relationship between personality traits and distinct depression dimensions in older adults with T2D.MethodsParticipants were older adults (age ≥65yeas) with T2D from the Israel Diabetes and Cognitive Decline (IDCD) study (N = 356), with complete data on depression [Geriatric Depression Scale (GDS) ‐ 15 item version] and its dimensions‐ namely, dysphoric mood, apathy, hopelessness, memory complains and anxiety, and on personality [Big Five Inventory (BFI)]. Logistic and mixed linear regression models examined cross‐sectional and longitudinal associations while adjusting for socio‐demographics, cognition, cardiovascular and diabetes‐related factors.ResultsCross‐sectionally, high neuroticism was associated with high scores in total GDS and in all depression‐dimensions, except memory complaints. Higher extroversion was associated with lower total GDS and with lower scores on all depression dimensions, except anxiety. High levels of neuroticism were associated with increase in total number of depression symptoms over time.ConclusionsIn older adults with T2D, neuroticism and extroversion are associated with most depression dimensions suggesting that these traits relate to a global depression symptomatology rather than to any specific dimension or phenomenology. High neuroticism was associated with increase in depression symptoms over time, highlighting its role in the development of depression symptoms in older adults with T2D.
Relationship between maternal antenatal attachment and traumatic childbirth perception among pregnant women
Authors: Şahin Merve , Erbil Nülüfer 
Published: October 2023

AbstractObjectiveTo examine the relationship between the perception of traumatic birth and maternal attachment in pregnant women.MethodsThis descriptive and correlational study recruited 370 pregnant women who applied for an antenatal visit to outpatient clinics of a state hospital. The data were collected using a Personal Information Form, Maternal Antenatal Attachment Scale (MAAS), and Traumatic Birth Perception Scale (TBPS). Data were collected using the face‐to‐face method. The study was reported according to the STROBE.ResultsThe mean total score of MAAS was 75.71 ± 7.72 and the mean TBPS score was 73.21 ± 28.34. Normal birth pain was perceived as “severe” by 38.3% of pregnant women and as “very severe” by 46.1%. It was determined that 29.2% of pregnant women had a “high” level of traumatic birth perception and 14.5% had a “very high” level. A negative correlation was found between the mean scores of MAAS and TBPS of pregnant women. The trimester of pregnancy, listening to the birth story, planned pregnancy, and traumatic birth perception, was a significant predictor of maternal antenatal attachment.ConclusionAs the maternal antenatal attachment levels of pregnant women increased, their perceptions of traumatic birth decreased.
DNA Replication and Germ Cell Apoptosis During Spermatogenesis in the Cat
Authors: BLANCO‐RODRÍGUEZ JOSEFA 
Published: October 2023

ABSTRACTStages at which DNA synthesis and germ cell death take place have recently been found to be equivalent in rabbits and rats. Preservation of the timing of these processes in different orders of mammals indicates that this timing may be crucial for testis cell biology. Since there is no previous study on either germ cell proliferation or apoptosis in upper mammals, an analysis of DNA replication (by bromodeoxyuridine labeling) and of the location of apoptotic germ cells (by the TUNEL assay) has been performed in 3 young adult cats. Our observations indicated that in this animal, spermatogonial DNA synthesis occurs at stages V (at which point the first generation of replicating spermatogonia appears, together with replicating preleptotene spermatocytes), early VII, VIII, and early I, II, and IV. Apoptosis of both spermatogonia and spermatocytes was located mostly at stages early I, early VI, early VII, and VIII. Interestingly, DNA synthesis and germ cell death were found to occur at the same stages of the spermatogenic cycle (that is, to occur at the same specific stages of development) as those reported for the rabbit and small rodents.
Melatonin Administration Alters Semen Quality in Healthy Men
Authors: LUBOSHITZKY RAFAEL , SHEN‐ORR ZILLA , NAVE RACHEL , LAVI SCHAHAR , LAVIE PERETZ 
Published: October 2023

ABSTRACTThe role of melatonin in the regulation of reproduction in humans is unknown. We conducted a 6‐month, double‐blind, cross‐over study of a daily treatment dose of 3 mg melatonin or placebo given orally at 1700 hours in 8 healthy men. Semen quality (concentration, motility, and morphology), serum and seminal plasma 17‐β‐estradiol (E2), testosterone, melatonin, and serum gonadotropin levels were determined every 3 months throughout the study. In 6 men, there was no change in semen quality or in serum and seminal plasma hormone levels during the study period. In 2 men, during the melatonin treatment period, sperm concentration decreased to 3 × 106/mL and 12 × 106/mL, and motility declined to 32% and 30%. These coincided with a decline in seminal plasma and serum E2 levels and with an increase in testosterone: E2 ratios. Six months after the cessation of melatonin, sperm concentration and motility were normal in 1 man but remained abnormal in the other one with a still elevated testosterone: E2 ratio. Serum gonadotropin levels were unchanged during the study in all 8 men. Our preliminary observations suggest that long‐term melatonin administration is associated with decreased semen quality in a number of healthy men, probably through the inhibition of aromatase at the testicular level.
Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells
Authors: Gao Jiaming , Wang Hao , Shen Junyan , Liu Xiaojing , Zhu Xiaoqi , Huang Ce , Li Gongchen , Sun Yao , Liu Zhongmin , Sun Yi Eve , Liu Hailiang 
Published: October 2023

AbstractGrowth differentiation factor 11 (GDF11) is a putative systemic rejuvenation factor. In this study, we characterized the mechanism by which GDF11 reversed aging of mesenchymal stem cells (MSCs). In culture, aged MSCs proliferate slower and are positive for senescence markers senescence‐associated β‐galactosidase and P16ink4a. They have shortened telomeres, decreased GDF11 expression, and reduced osteogenic potential. GDF11 can block MSC aging in vitro and reverse age‐dependent bone loss in vivo. The antiaging effect of GDF11 is via activation of the Smad2/3‐PI3K‐AKT‐mTOR pathway. Unexpectedly, GDF11 also upregulated a DNA demethylase Tet2, which served as a key mediator for GDF11 to autoregulate itself via demethylation of the GDF11 promoter. Mutation of Tet2 facilitates MSC aging by blocking GDF11 expression. Mutagenesis of Tet2‐regulated CpG sites also blocks GDF11 expression, leading to MSC aging. Together, a novel mutual regulatory relationship between GDF11 and an epigenetic factor Tet2 unveiled their antiaging roles.