bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Adverse Events of Medialization Thyroplasty: A Systematic Review
Authors: Valley Zachary A. , Karp Avrohom , Garber David 
Published: November 2023

IntroductionUnilateral vocal fold paralysis or paresis (UVFP) is a condition that causes significant morbidity due to dysphonia, dysphagia, and aspiration. Type I medialization thyroplasty (MT) is the current mainstay surgical treatment for UVFP. Though widely considered a safe procedure, concerns exist over possible airway complications which can lead to overnight observation. Herein, we report a systematic review of the safety and adverse events of MT to aid in determining the safety of same‐day discharge.Data SourcesPubMed and Embase databases.Review MethodsOur search identified studies investigating complications associated with MT. Articles were selected if published between January 1, 1989 and March 15, 2023. Abstracts were screened, and data were extracted from included studies. Only Type I MT procedures were included; case reports were excluded. Participant characteristics, intervention details, results, and adverse events were extracted.ResultsThe database query identified 751 abstracts, of which 46 studies met eligibility criteria. A total of 2426 patients underwent MT. The most common implant was Silastic (n = 898, 37.0%) followed by Gore‐Tex (n = 664, 27.4%). There were 254 (10.5%) total complications reported; 110 (4.5%) were considered major. The most common complication was nonobstructive hematoma (n = 59, 2.4%) followed by hemorrhage (n = 36, 1.5%). Implant extrusion (n = 24, 0.99%) or displacement (n = 15, 0.62%) occurred mostly in Silastic and Gore‐Tex implants. Same‐day discharge occurred with 429 patients and was not associated with adverse events.ConclusionsUVFP can be reliably improved by MT with a low risk of complications. Outpatient MT is a promising treatment with a favorable safety profile. Laryngoscope, 134:1994–2004, 2024
BLOOM: A NEW LEADERSHIP DUTY OF CARE
Authors: Pontefract Dan 
Published: November 2023

AbstractThe author, a leadership strategist, discusses the concept of bloom, and its meanings for leadership. “Several factors,” he states, “influence the ability (or inability) of people to flourish at work. But the same is true for their lives. Thus, the relationship between work and life has become more critical than ever. Leaders: you have a responsibility for this work‐life outcome.” He suggests renouncing three familiar organizational terms: Work‐life balance, bring your best self to work, and employee engagement. As a replacement concept: “What is that new philosophy? I call it bloom. At the intersection of work and life, you should begin aspiring to reach a state of blooming. As a leader, you must begin applying the same thinking while leading your team members.” A table contrasts work‐factors (trust, belonging, valued, purpose, strategy, norms) and life‐factors (relationships, skills, well‐being, meaning, agency, respect). He develops four work‐life personas (renewal, budding, stunted, blooming). Blooming is described as “I am prospering fully in both work and life.” He concludes: “When we work, we bring our lives into our jobs every day, and our work creeps into our lives every day as well. There is no escaping the relationship between work and life. It is time to enact a new leadership duty of care.”
THE FIVE KEY QUALITIES OF LEVEL 5 LEADERS AND HOW WE CAN DEVELOP THEM IN FUTURE LEADERS
Authors: Taylor David , McArthur Sarah 
Published: November 2023

AbstractThe authors (Chartered Engineer & Business Leader at Rolls‐Royce and Editor‐in‐Chief of Leader to Leader) build on the concept of “level 5 leaders,” from Jim Collins's classic book Good to Great. They outline and describe the concept, and write that their “review of 7 out of 11 of the level 5 leaders in Jim's book showed the following 5 leadership qualities that created this combination of humility and will.” Those qualities, in their words, are: 1. Purpose before profits 2. Connection before critical thinking 3. Service before seniority 4. Creativity before control 5. Coaching for mastery. Each of these qualities is outlined in depth regarding recent leaders: Frances Hesselbein (Former CEO of Girl Scouts of the USA, Namesake of Frances Hesselbein Leadership Forum, Founder and longtime Editor‐in‐Chief of Leader to Leader, Presidential Medal of Freedom recipient); Alan Mulally, (Former CEO of Boeing Commercial Airplanes, Boeing Defense and Space, and the Ford Motor Company); and Hubert Joly (Former Chairman and CEO of Best Buy, recognized top 10 U.S. CEO, Glassdoor: Unleashing Human Magic). They write that these leaders “advocate an approach where all stakeholders are included to create insights, implement change, and follow up to deliver sustainable and long‐term improvement.”
Cognitive Effects of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease with GBA1 Pathogenic Variants
Authors: Pal Gian D. , Corcos Daniel M. , Metman Leo Verhagen , Israel Zvi , Bergman Hagai , Arkadir David 
Published: November 2023

AbstractGenetic subtyping of patients with Parkinson's disease (PD) may assist in predicting the cognitive and motor outcomes of subthalamic deep brain stimulation (STN‐DBS). Practical questions were recently raised with the emergence of new data regarding suboptimal cognitive outcomes after STN‐DBS in individuals with PD associated with pathogenic variants in glucocerebrosidase gene (GBA1‐PD). However, a variety of gaps and controversies remain. (1) Does STN‐DBS truly accelerate cognitive deterioration in GBA1‐PD? If so, what is the clinical significance of this acceleration? (2) How should the overall risk‐to‐benefit ratio of STN‐DBS in GBA1‐PD be established? (3) If STN‐DBS has a negative effect on cognition in GBA1‐PD, how can this effect be minimized? (4) Should PD patients be genetically tested before STN‐DBS? (5) How should GBA1‐PD patients considering STN‐DBS be counseled? We aim to summarize the currently available relevant data and detail the gaps and controversies that exist pertaining to these questions. In the absence of evidence‐based data, all authors strongly agree that clinicians should not categorically deny DBS to PD patients based solely on genotype (GBA1 status). We suggest that PD patients considering DBS may be offered genetic testing for GBA1, where available and feasible, so the potential risks and benefits of STN‐DBS can be properly weighed by both the patient and clinician. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Preparation of robust and light‐weight anisotropic polyimide/graphene composite aerogels for strain sensors
Authors: Zheng Shuai , Jiang Lei , Chang Fan , Zhang Changqi , Ma Ning , Liu Xueqiang 
Published: November 2023

AbstractThis study reports the fabrication of a serious of anisotropic composite aerogels comprising polyimide and graphene (PI/G) through a simple and eco‐friendly technique. Poly(amic acid) ammonium salt/graphene dispersion, which was produced through the mixture of poly(amic acid), graphene aqueous dispersion, triethylamine, and water, was utilized in the process of creating PI/G composite aerogels employing unidirectional freezing, freeze‐drying, and thermal imidization. The PI/G aerogels displayed anisotropic mechanical properties, thermal insulation, and electrical conductivity. The PI/G aerogels with an anisotropic microstructure demonstrated notable rigidity and a high compressive modulus (52.7 MPa) along the axial direction, while displaying favorable flexibility and a low modulus (18.2 MPa) along the radial direction. Furthermore, the PI/G aerogel exhibited anisotropic thermal conductivity (axial: 64 mW m−1 K−1; radical: 55 mW m−1 K−1). These properties enable the PI/G aerogel to have a wider range of potential applications, especially strain sensors. The research presented herein establishes a simple and eco‐friendly strategy for the production of anisotropic PI/G‐based composite aerogels.
Atmospheric pressure plasma application on the adhesive bonding improvement of CFRP via surface configuration comparison
Authors: Guo Weijia , Lim Yi Chang , Ong Cheng Huat , A. Senthil Kumar 
Published: November 2023

AbstractCarbon fiber reinforced polymer (CFRP) has a wide range of applications in aerospace, automobile, marine, and other industries, due to its remarkable mechanical properties and lightweight. It can enhance the performance of the structural components and has been presented to be a good alternative over conventional materials. Adhesive bonding has been widely employed, and research studies on the surface modification of CFRP have been conducted to improve the load resistance of adhesive bonding, of which atmospheric pressure (AP) plasma is the most preferred method. However, there is still a lack of study on the effectiveness and strategies of AP plasma surface modification. To gain more insight, possible sources that would have influence on the adhesive bonding were analyzed by preparation of different surface configurations of CFRP. It is confirmed that AP plasma can increase the surface polarity and wettability of the carbon fiber surface. It can contribute to the removal of surface contamination element as well. Although the surface morphology and surface roughness before and after the AP plasma treatment does not show noticeable changes, the single‐lap shear strength of the contaminated samples can be effectively improved. This study validates that AP plasma is effective on surface contamination removal and bonding quality improvement, which provides a potential alternative for the adhesive bonding improvement and surface modification of carbon fiber.Highlights
Surface polarity and wettability increase of CFRP by AP plasma.
Surface contamination removal and bonding quality improvement by AP plasma.
AP plasma provides a potential alternative method for adhesive bonding pre‐treatment.
AP plasma surface modification mechanism analysis via surface characterization.
The clinical condition rather than cerebrospinal fluid levels may guide the optimal duration of antimicrobial therapy among neonates with bacterial meningitis: A single‐center retrospective study
Authors: Hu Ya , Li Xingyuan , Wei Hong , Luo Yuanyuan , Li Hongdong 
Published: November 2023

AbstractNeonatal bacterial meningitis is serious and accounts for high morbidity and mortality in developing countries, but the duration of antimicrobial treatment is not well established. Cerebrospinal fluid (CSF) levels are important factors for diagnosing and monitoring the occurrence and development of bacterial meningitis. In this study, we aimed to compare the clinical characteristics and outcomes of neonatal bacterial meningitis with normal CSF and abnormal CSF at discharge. We enrolled neonates with bacterial meningitis who were admitted to the neonatology department of the Children's Hospital of Chongqing Medical University between August 1, 2019 and January 1, 2021. The children's clinical data, laboratory data, and outcomes were recorded and analyzed. Fifty‐five neonates met the inclusion criteria in our study. Other than CSF protein levels, there was no significant difference in clinical symptoms, blood levels (white blood cell [WBC] count, neutrophils, platelets, C‐reactive protein, and procalcitonin), CSF WBC counts at admission and discharge, duration of antibiotics, or hospital stays between the two groups (p > 0.05). For the sequelae of bacterial meningitis, short‐ and long‐term complications also showed no statistically significant differences between the two groups. The duration of antimicrobial therapy in neonatal bacterial meningitis may depend on the clinical condition of the patient rather than the CSF levels. This study may improve the reasonable utilization of antibiotics in neonatal bacterial meningitis.
Wie viel wiegt das Vakuum?
Authors: Kempf Achim , Jonsson Robert , Pye Jason , Rosa Luigi , Calloni Enrico 
Published: November 2023

ZusammenfassungDas Vakuum ist nicht völlig leer, denn die Heisenbergsche Unschärferelation erzwingt Vakuumfluktuationen. Deren Existenz ist über Messungen der Casimir‐Kraft belegt. Folglich muss auch Energie in den Vakuumfluktuationen stecken, die sich nach E = mc2 in Form von Gravitation bemerkbar machen sollte. Nach der Allgemeinen Relativitätstheorie müsste ihre Gravitation die Expansion des Universums beschleunigen. Allerdings wäre die Gravitationswirkung, die sich theoretisch aus der quantenmechanisch ermittelten Grundzustandsenergie des Vakuums ergibt, um etwa 120 Größenordnungen zu groß. Dieser Widerspruch ist eine der grundlegenden, ungeklärten Fragestellungen der Physik. Auf der Suche nach einer Antwort soll das Archimedes‐Experiment als extrem empfindliche Waage die Energiedichte des Vakuums bestimmen. Das Resultat soll Hinweise auf die Ursache des „Problems der kosmologischen Konstante“ liefern.
Evaluation of sleep health documentation and sleep‐related intervention by physiatrists treating musculoskeletal disorders: A retrospective investigation
Authors: Deo Prabhav , Leupold Olivia , Rau Olivia , Cheng Jennifer , Prather Heidi 
Published: November 2023

AbstractBackgroundSleep health is linked to pain, function, and global health. Unfortunately, sleep health may not be consistently addressed as a part of musculoskeletal care.ObjectiveTo describe the frequency of sleep health documentation and intervention by musculoskeletal physiatrists. Additionally, patient‐reported outcome measures were compared between patients with and without sleep impairment. We hypothesized that sleep health is documented and addressed in less than half of initial patient encounters and that patients with a sleep impairment have worse patient‐reported outcomes scores compared to those without sleep impairment.DesignRetrospective study.SettingTertiary orthopedic hospital.InterventionsNone.Main Outcome MeasuresFrequency of provider documentation of sleep health, frequency and characteristics of sleep health intervention provided, and Patient‐Reported Outcome Measurement Information System (PROMIS)‐10 mental health and physical health scores.ResultsInitial visits for a musculoskeletal condition of 39,452 patients from January 1, 2020 to October 1, 2022 were included. Documentation of sleep health was found in 33.0% (13,002/39,452) of patients. Of those with sleep health documentation, 59.2% (7697/13,002) were classified as having a sleep impairment. Only 19.0% of patients were provided with sleep‐related education or other intervention. Patients with a sleep impairment had worse PROMIS‐10 mental health and physical health scores (p < .001), as compared to those without a sleep impairment.ConclusionsPatients with sleep impairment had worse mental and physical health scores than those without sleep impairment, and only 19.0% received sleep health intervention. These data suggest that sleep impairment is common in patients presenting for evaluation of a musculoskeletal condition, and advanced provider education and tools to help patients improve their sleep health are needed.
TNT and RDX extraction from B explosives**
Authors: Liu Zhiyu , Wang Quan , Su Haoxiang , Li Rui , Zhang Kai , Liu Quan 
Published: November 2023

AbstractThe recycling of discarded military bombs holds significant importance in improving energy efficiency within the military field. In this study, we employed first‐principles calculations (DFT) to compute the affinity of toluene, acetone, and dimethyl sulfoxide (DMSO) towards TNT and RDX, highlighting the solubility differences that enable their effective separation. Furthermore, through recovery and separation experiments, we successfully obtained TNT and RDX samples, which were then characterized using gas chromatography‐mass spectrometry (GC‐MS) and scanning electron microscopy (SEM) to experimentally validate the results obtained from molecular simulation experiments. The results revealed that using toluene for the extraction and recovery of TNT and RDX from waste B explosives yielded the highest recovery efficiency and component purity. SEM analysis showed that TNT extracted with toluene exhibited a regular layered surface, while RDX particles demonstrated a more uniform distribution. This study provides a theoretical basis for the separation and recovery of TNT and RDX from waste B explosives using extraction methods, from the perspective of molecular simulation.
Study on synthesis and characterization of spherical copper(I) 5‐nitrotetrazolate (DBX‐1)
Authors: Yang Tsung‐Mao , Lai Jia‐Tong , Li Wen‐Hsiang , Peng Cheng‐Hsiung , Li Jin‐Shuh , Lu Kai‐Tai 
Published: November 2023

AbstractTraditional primary explosives often contain heavy metals, especially toxic lead, such as lead azide (LA) and lead styphnate (LS) that can cause environmental pollution problems. Copper(I) 5‐nitrotetrazolate (DBX‐1) is a green primary explosive without toxic heavy metals, which is considered as one of the most promising alternatives to LA. DBX‐1 is usually synthesized from sodium 5‐nitrotetrazolate dihydrate (NaNT ⋅ 2H2O) and copper(I) chloride (CuCl). However, most of the synthesized products are irregular flakes with poor flowability, which affects the loadability. In this study, dextrin was used as a crystal shape modifier to improve the morphology of the synthesized product. Taguchi analysis method was used to determine the optimal experimental conditions for obtaining the spherical DBX‐1 with smaller particle size. The synthesized products were characterized by SEM, FTIR, UV‐Vis, STA TG‐DSC and VST, and their sensitivity was determined by BAM fallhammer, BAM friction tester and electrostatic spark sensitivity tester. The experiment results showed that the optimal combination of synthesis parameters was the NaNT ⋅ 2H2O concentration of 4.4 wt.%, the reaction temperature of 100 °C, the reaction time of 75 min and the additional dextrin solution of 5.0 mL. The average particle size of the synthesized spherical DBX‐1 was 33.0 μm. The decomposition activation energy was calculated by Kissinger method and Ozawa method to be 178.5 and 178.8 kJ/mol, respectively. The compound had good chemical stability. In addition, the sensitivity of spherical DBX‐1 was lower compared to that of flaky DBX‐1 and LA.
Lectin‐anticancer peptide fusion demonstrates a significant cancer‐cell‐selective cytotoxic effect and inspires the production of “clickable” anticancer peptide in Escherichia coli
Authors: Pasupuleti Rajeev , Riedl Sabrina , Saltor Núñez Laia , Karava Marianna , Kumar Vajinder , Kourist Robert , Turnbull W. Bruce , Zweytick Dagmar , Wiltschi Birgit 
Published: November 2023

AbstractTargeted killing of tumor cells while protecting healthy cells is the pressing priority in cancer treatment. Lectins that target a specific glycan marker abundant in cancer cells can be valuable new tools for selective cancer cell killing. The lectin Shiga‐like toxin 1 B subunit (Stx1B) is an example that specifically binds globotriaosylceramide (CD77 or Gb3), which is overexpressed in certain cancers. In this study, a human lactoferricin‐derived synthetic retro di‐peptide R‐DIM‐P‐LF11‐215 with antitumor efficacy was fused to the lectin Stx1B to selectively target and kill Gb3+ cancer cells. We produced lectin‐peptide fusion proteins in Escherichia coli, isolated them by Gb3‐affinity chromatography, and assessed their ability to selectively kill Gb3+ cancer cells in a Calcein AM assay. Furthermore, to expand the applications of R‐DIM‐P‐LF11‐215 in developing therapeutic bioconjugates, we labeled R‐DIM‐P‐LF11‐215 with the unique reactive non‐canonical amino acid Nε‐((2‐azidoethoxy)carbonyl)‐L‐lysine (AzK) at a selected position by amber stop codon suppression. The R‐DIM‐P‐LF11‐215 20AzK and the unlabeled R‐DIM‐P‐LF11‐215 parent peptide were produced as GST‐fusion proteins for soluble expression in E. coli for the first time. We purified both variants by size‐exclusion chromatography and analyzed their peptide masses. Finally, a cyanin 3 fluorophore was covalently conjugated to R‐DIM‐P‐LF11‐215 20AzK by strain‐promoted alkyne‐azide cycloaddition. Our results showed that the recombinant lectin‐peptide fusion R‐DIM‐P‐LF11‐215‐Stx1B killed >99% Gb3+ HeLa cells while Gb3‐negative cells were unaffected. The peptides R‐DIM‐P‐LF11‐215 and R‐DIM‐P‐LF11‐215 20AzK were produced recombinantly in E. coli in satisfactory amounts and were tested functional by cytotoxicity and cell‐binding assays, respectively.
Energetic and structural insights behind calcium induced conformational transition in calmodulin
Authors: Halder Ritaban , Warshel Arieh 
Published: November 2023

AbstractCalmodulin (CaM) is a key signaling protein that triggers several cellular and physiological processes inside the cell. Upon binding with calcium ion, CaM undergoes large scale conformational transition from a closed state to an open state that facilitates its interaction with various target protein and regulates their activity. This work explores the origin of the energetic and structural variation of the wild type and mutated CaM and explores the molecular origin for the structural differences between them. We first calculated the sequential calcium binding energy to CaM using the PDLD/S‐LRA/β approach. This study shows a very good correlation with experimental calcium binding energies. Next we calculated the calcium binding energies to the wild type CaM and several mutated CaM systems which were reported experimentally. On the structural aspect, it has been reported experimentally that certain mutation (Q41L‐K75I) in calcium bound CaM leads to complete conformational transition from an open to a closed state. By using equilibrium molecular dynamics simulation, free energy calculation and contact frequency map analysis, we have shown that the formation of a cluster of long‐range hydrophobic contacts, initiated by the Q41L‐K75I CaM variant is the driving force behind its closing motion. This study unravels the energetics and structural aspects behind calcium ion induced conformational changes in wild type CaM and its variant.
iNucRes‐ASSH: Identifying nucleic acid‐binding residues in proteins by using self‐attention‐based structure‐sequence hybrid neural network
Authors: Zhang Jun , Chen Qingcai , Liu Bin 
Published: November 2023

AbstractInteraction between proteins and nucleic acids is crucial to many cellular activities. Accurately detecting nucleic acid‐binding residues (NABRs) in proteins can help researchers better understand the interaction mechanism between proteins and nucleic acids. Structure‐based methods can generally make more accurate predictions than sequence‐based methods. However, the existing structure‐based methods are sensitive to protein conformational changes, causing limited generalizability. More effective and robust approaches should be further explored. In this study, we propose iNucRes‐ASSH to identify nucleic acid‐binding residues with a self‐attention‐based structure‐sequence hybrid neural network. It improves the generalizability and robustness of NABR prediction from two levels: residue representation and prediction model. Experimental results show that iNucRes‐ASSH can predict the nucleic acid‐binding residues even when the experimentally validated structures are unavailable and outperforms five competing methods on a recent benchmark dataset and a widely used test dataset.