bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of social determinants of health on time to antiretroviral therapy initiation and HIV viral undetectability for migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite B/F/TAF: ‘The ASAP study’
Authors: Arora Anish K. , Vicente Serge , Engler Kim , Lessard David , Huerta Edmundo , Ishak Joel , Routy Jean‐Pierre , Klein Marina , Kronfli Nadine , Cox Joseph , Lemire Benoit , de Pokomandy Alexandra , Del Balso Lina , Sebastiani Giada , Vedel Isabelle , Quesnel‐Vallée Amélie ,   ASAP Migrant Advisory Committee, Lebouché Bertrand 
Published: January 2024

AbstractObjectiveMultidisciplinary care with free, rapid, and on‐site bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) dispensation may improve health outcomes among migrants living with HIV. However, models for rapid B/F/TAF initiation are not well studied among migrants living with HIV, and an understanding of how social determinants of health (SDH) may affect HIV‐related health outcomes for migrants enrolled in such care models is limited.MethodsWithin a 96‐week pilot feasibility prospective cohort study at a multidisciplinary HIV clinic, participants received free B/F/TAF rapidly after care linkage. The effects of SDH (i.e., birth region, sexual orientation, living status, education, employment, French proficiency, health coverage, use of a public health facility outside our clinic for free blood tests, and time in Canada) and other covariates (i.e., age, sex) on median time to antiretroviral therapy (ART) initiation and HIV viral undetectability from care linkage were calculated via survival analyses.ResultsThirty‐five migrants were enrolled in this study. Median time to ART initiation and HIV undetectability was 5 days (range 0–50) and 57 days (range 5–365), respectively. Those who took significantly longer to initiate ART were aged <35 years, identified as heterosexual, had less than university‐level education, or were unemployed. No factor was found to significantly affect time to undetectability.ConclusionDespite the provision of free B/F/TAF, several SDH were linked to delays in ART initiation. However, once initiated and engaged, migrants living with HIV reached HIV undetectability efficiently. Findings provide preliminary support for adopting this care model with migrants living with HIV and suggest that SDH should be considered when designing clinical interventions for more equitable outcomes.
Location and visa‐category determinants of naturalization in Australia
Authors: Tan Yan , Liu Xuchun 
Published: January 2024

AbstractImmigrants' naturalization is conditioned by demographic, socioeconomic and contextual factors, but little is known about how it is affected by permanent visa category and geographic location at the destination. Using the 2016 Australian Census and Migrants Integrated Dataset (ACMID) and Probit regression analysis, we examined how visa category and location of residence influence naturalization rates for Chinese and Indian migrants arriving in Australia between 2000 and 2016. Chinese migrants were most likely to naturalize if entering under a Humanitarian visa, and Indian migrants if under a Skilled Independent visa. Migrants in the Australian Capital Territory were the most likely to naturalize, and those in Victoria the least likely—a distinction sharpened by metropolitan as opposed to regional location. The transnational perspective, allied with cost–benefit and integration theories, performs well in accounting for these heterogeneities. The differences have clear policy and practice in Australia and for countries of origin.
Fabry‐specific treatment in Australia: time to align eligibility criteria with international best practices
Authors: Nicholls Kathleen , Denaro Charles , Tchan Michel , Ellaway Carolyn , Bratkovic Drago , Campbell Sheridan , Fookes Megan , Thomas Mark 
Published: January 2024

AbstractBackgroundDisease‐specific therapy aims to improve symptoms, stabilise current disease and delay progression in patients with Fabry disease. In Australia, treatment access is subject to eligibility criteria initially established in 2004. Patients and their clinicians question why these criteria have remained unchanged despite significant progress in disease understanding.AimsAppraise the clinical quality of the Australian treatment access criteria.MethodsThe Fabry Australia Medical Advisory Committee (N = 6) used the Appraisal of Guidelines for REsearch and Evaluation Global Rating Scale (AGREE II GRS) to assess the clinical quality of the current treatment eligibility criteria. They reviewed the literature, developed 17 clinical statements to help guide reforms of the eligibility criteria and achieved consensus (achievement of ≥75% agreement in the range 5–7 on a 7‐point Likert scale) through anonymous voting. The findings were applied to develop proposals for revised classification and treatment initiation criteria.ResultsThe current treatment eligibility criteria underperformed on the AGREE II GRS. They are pragmatic but out‐of‐step with contemporary data. Consensus was achieved on all 17 proposed clinical statements. There was strong agreement to differentiate classical male Fabry patients to facilitate timelier access to Fabry‐specific treatment. There was also agreement on the value of adopting relevant organ involvement criteria in classical female patients and patients with non‐classical disease.ConclusionsAustralian access criteria are misaligned with current clinical evidence. The clinical statements and proposed classification and initiation criteria should prompt discussions to support more equitable access to treatment and better align Australian practice with contemporary evidence and international guidelines.
What's the point? Infants' and adults' perception of different pointing gestures
Authors: Ger Ebru , Wermelinger Stephanie , de Ven Maxine , Daum Moritz M. 
Published: January 2024

AbstractAdults and infants as young as 4 months old orient to pointing gestures. Although adults are shown to orient faster to index‐finger pointing than other hand shapes, it is unknown whether hand shapes influence infants' perception of pointing. In this study, we used a spatial cueing paradigm on an eye tracker to investigate whether and to what extent adults and 12‐month‐old infants orient their attention in the direction of pointing gestures with different hand shapes: index finger, whole hand, and pinky finger. Furthermore, we assessed infants' and their parents' pointing production. Results revealed that adults showed a reliable cueing effect: shorter saccadic reaction times (SRTs) to congruent than incongruent targets, for all hand shapes. However, they did not show a larger cueing effect triggered by the index or any other finger. This contradicts previous findings and is discussed with respect to the differences in methodology. Infants showed a cueing effect only for the whole hand but not for the index or pinky fingers. The current results suggest that infants' orienting to pointing may be more robust for the whole hand shape in the first year, and tuning in to the social‐communicative relevance of the canonical index finger shape may develop later or require additional social‐communicative cues.
Do competitive bonuses ruin cooperation in heterogeneous teams?
Authors: Glenn Dutcher E. , Oexl Regine , Ryvkin Dmitry , Salmon Timothy C. 
Published: January 2024

AbstractA debate among practicing managers is whether to use cooperative or competitive incentives for team production. While competitive incentives may drive individual effort higher, they may also lead to less help and more sabotage, with unclear consequences overall, especially when team members' abilities differ. Using a lab experiment, we examine how increasing competitive incentives affects performance as team composition changes. We find that competitive incentives generally under‐perform noncompetitive incentives and a larger bonus does not generate enough effort to compensate for a loss in help. Our results help understand better how to balance out individual versus team rewards and how firms could structure teams when employees have heterogeneous abilities.
Association of metabolic dysfunction‐associated fatty liver disease with gallstone development: A longitudinal study
Authors: Sogabe Masahiro , Okahisa Toshiya , Kagawa Miwako , Sei Motoko , Kagemoto Kaizo , Tanaka Hironori , Kida Yoshifumi , Nakamura Fumika , Tomonari Tetsu , Okamoto Koichi , Miyamoto Hiroshi , Sato Yasushi , Nakasono Masahiko , Takayama Tetsuji 
Published: January 2024

AbstractBackground and AimThe influence of metabolic dysfunction‐associated fatty liver disease on gallstone development remains unclear. We aimed to investigate the longitudinal association between metabolic dysfunction‐associated fatty liver disease and gallstone development in both men and women.MethodsThis observational cohort study included 5398 patients without gallstones who underwent > 2 health check‐ups between April 1, 2014, and March 31, 2020. A generalized estimation equation model was used to analyze the association between metabolic dysfunction‐associated fatty liver disease and gallstone development according to repeated measures at baseline and most recent stage.ResultsAfter adjustment, the odds ratios of metabolic dysfunction‐associated fatty liver disease for gallstone development in men and women were 3.019 (95% confidence interval [CI]: 1.901–4.794) and 2.201 (95% CI: 1.321–3.667), respectively. Among patients aged ≥ 50 years, the odds ratio for gallstone development was significantly enhanced with increasing metabolic dysfunction‐associated fatty liver disease component numbers in both sexes; however, no significance was observed in those aged < 50 years. Other significant risk factors for gallstone development were age (odds ratio: 1.093, 95% CI: 1.060–1.126) and waist circumference (odds ratio: 1.048, 95% CI: 1.018–1.079) in men and age (odds ratio: 1.035, 95% CI: 1.003–1.067) and current smoking (odd ratio: 5.465, 95% CI: 1.881–15.88) in women.ConclusionAlthough the risk factors for gallstone development differed between sexes, metabolic dysfunction‐associated fatty liver disease was common. Paying attention to an increase in the number of metabolic dysfunction‐associated fatty liver disease components in patients aged ≥ 50 years is important for gallstone prevention.
ArUco‐based stylus reliability for reproductible 3D digitalisation of shoulder cartilage contours
Authors: Moissenet Florent , Elmo Kulanesan Christian , Co Kevin , Rodriguez Pablo , Vacher Pierre , Beaulieu Jean‐Yves , Holzer Nicolas 
Published: January 2024

AbstractImaging techniques in anatomy have developed rapidly over the last decades through the emergence of various 3D scanning systems. Depending on the dissection level, non‐contact or tactile contact methods can be applied on the targeted structure. The aim of this study was to assess the inter and intra‐observer reproducibility of an ArUco‐based localisation stylus, that is, a manual technique on a hand‐held stylus. Ten fresh–frozen, unembalmed adult arms were used to digitalise the glenoid cartilage related to the glenohumeral joint and the contour of the clavicle cartilage related to the acromioclavicular joint. Three operators performed consecutive digitalisations of each cartilage contour using an ArUco‐based localisation stylus recorded by a single monocular camera. The shape of each cartilage was defined by nine shape parameters. Intra‐observer repeatability and inter‐observer reproducibility were computed using an intra‐class correlation (ICC) for each of these parameters. Overall, 35.2 ± 2.4 s and 26.6 ± 10.2 s were required by each examiner to digitalise the contour of a glenoid and acromioclavicular cartilage, respectively. For most parameters, good‐to‐excellent agreements were observed concerning intra‐observer (ICC ranging between 0.81 and 1.00) and inter‐observer (ICC ranging between 0.75 and 0.99) reproducibility. To conclude, through a fast and versatile process, the use of an ArUco‐based localisation stylus can be a reliable low‐cost alternative to conventional imaging methods to digitalise shoulder cartilage contours.
An upcycled fraction of Melaleuca alternifolia essential oil regenerates the skin through the skin melatonin pathway and improves sleep quality
Authors: Duroux Romain , Jain Anshul , Tabert Matthias , Attia Joan 
Published: January 2024

AbstractBackgroundSleep is one of the most important factors affecting overall health. During the night, the skin repairs damage caused by daily stresses. Melatonin plays a key role in this process. Toxins are removed, and cellular repair and growth hormone production are increased. Inter alia, this also decreases signs of intrinsic aging.AimsThe current study was intended to demonstrate the impact of a unique fraction of Melaleuca alternifolia (FMA) essential oil, on sleep and skin quality.MethodsThe effect of FMA was investigated in vitro on skin cells, evaluating its antioxidant and anti‐inflammatory properties, and in an ex‐vivo study on human skin biopsies treated with FMA following stress induction. In addition, two clinical studies were performed on volunteers with life‐style‐related sleep complaints. In one study, sleep was measured using a noncontact monitoring device (SleepScore Labs, Max). A second study was conducted to assess skin anti‐aging effects.ResultsIn vitro application of FMA reduced IL‐8 and reactive oxygen species (ROS) generation in skin cells. This was confirmed ex vivo through a decrease in inflammatory markers and an increase in antioxidant enzymes after stress induction. Interestingly, FMA also upregulated melatonin‐associated genes. Real‐world sleep tracking revealed that FMA significantly improved sleep quality, relative to unscented control. In vivo applications also showed a reduction in signs of aging.ConclusionThese results provide initial data to suggest that this unique FMA delivers skin anti‐aging benefits via a two‐pronged mode of action, improving sleep quality, and reducing skin inflammatory and oxidative stress.
Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases
Authors: Li Xiaokun , Lu Weiqin , Kharitonenkov Alexei , Luo Yongde 
Published: January 2024

AbstractHuman fibroblast growth factor 19 (FGF19, or FGF15 in rodents) plays a central role in controlling bile acid (BA) synthesis through a negative feedback mechanism. This process involves a postprandial crosstalk between the BA‐activated ileal farnesoid X receptor and the hepatic Klotho beta (KLB) coreceptor complexed with fibrobalst growth factor receptor 4 (FGFR4) kinase. Additionally, FGF19 regulates glucose, lipid, and energy metabolism by coordinating responses from functional KLB and FGFR1‐3 receptor complexes on the periphery. Pharmacologically, native FGF19 or its analogs decrease elevated BA levels, fat content, and collateral tissue damage. This makes them effective in treating both cholestatic diseases such as primary biliary or sclerosing cholangitis (PBC or PSC) and metabolic abnormalities such as nonalcoholic steatohepatitis (NASH). However, chronic administration of FGF19 drives oncogenesis in mice by activating the FGFR4‐dependent mitogenic or hepatic regenerative pathway, which could be a concern in humans. Agents that block FGF19 or FGFR4 signaling have shown great potency in preventing FGF19‐responsive hepatocellular carcinoma (HCC) development in animal models. Recent phase 1/2 clinical trials have demonstrated promising results for several FGF19‐based agents in selectively treating patients with PBC, PSC, NASH, or HCC. This review aims to provide an update on the clinical development of both analogs and antagonists targeting the FGF19–FGFR4 signaling pathway for patients with cholestatic, metabolic, and cancer diseases. We will also analyze potential safety and mechanistic concerns that should guide future research and advanced trials.
Role of neuropeptides in orofacial pain: A literature review
Authors: Wang Jian , Liu Xiangtao , Gou Junzhuo , Deng Jing , Li Mujia , Zhu Yafen , Wu Zhifang 
Published: January 2024

AbstractBackgroundNeuropeptides play a critical role in regulating pain and inflammation. Despite accumulating evidence has further uncovered the novel functions and mechanisms of different neuropeptides in orofacial pain sensation and transmission, there is deficient systematic description of neuropeptides' pain modulation in the orofacial region, especially in the trigeminal system.ObjectivesThe present review aims to summarise several key neuropeptides and gain a better understanding of their major regulatory roles in orofacial inflammation and pain.MethodsWe review and summarise current studies related to calcitonin gene‐related peptide (CGRP), substance P (SP), opioid peptide (OP), galanin (GAL) and other neuropeptides' functions and mechanisms as well as promising targets for orofacial pain control.ResultsA number of neuropeptides are clearly expressed in the trigeminal sensory system and have critical functions in the transduction and pathogenesis of orofacial pain. The functions, possible cellular and molecular mechanisms have been introduced and discussed. Neuropeptides and their agonists or antagonists which are widely studied to be potential treatment options of orofacial pain has been evaluated.ConclusionsVarious neuropeptides play important but distinct (pro‐nociceptive or analgesic) roles in orofacial pain with different mechanisms. In summary, CGRP, SP, NPY, NKA, HK‐1, VIP mainly play proinflammatory and pro‐nociceptive effects while OP, GAL, OXT, OrxA mainly have inhibitory effects on orofacial pain.
Objectively measured prolonged sleep is associated with plasma cytokines in older adults with mild cognitive impairment
Authors: Tokunaga Akari , Kimura Noriyuki , Masuda Teruaki , Hanaoka Takuya , Matsubara Etsuro 
Published: January 2024

SummaryThis study aimed to determine whether objective sleep time is associated with the concentrations of various plasma cytokines in older adults with mild cognitive impairment (MCI). In total, 118 adults with MCI (66 women; mean age: 75.7 years) participated in this prospective cohort study. All participants were required to wear a wristband sensor for 7.8 days, on average, every 3 months for 1 year and undergo measurement of 27 plasma cytokines using multiplex immunoassays. After adjusting for potential confounders, the associations of total sleep time with cytokine concentrations were assessed by multiple linear regression analysis. The total sleep time was significantly correlated with plasma interleukin (IL)‐9 and macrophage inflammatory protein (MIP)‐1β levels (r = 0.239, p = 0.009, and r = 0.242, p = 0.008, respectively). Moreover, these associations remained significant after adjusting for covariates, including demographic characteristics, lifestyle‐related diseases, and apolipoprotein E status (β = 0.272, 95% confidence interval: 0.095–0.448, p = 0.003, and β = 0.27, 95% confidence interval: 0.092–0.449, p = 0.003, respectively). Thus, this study is the first to demonstrate the association between objective prolonged sleep and higher plasma IL‐9 and MIP‐1β levels in older adults with MCI.
Urbanization reduces gut bacterial microbiome diversity in a specialist ground beetle, Carabus convexus
Authors: Magura Tibor , Mizser Szabolcs , Horváth Roland , Tóth Mária , Likó István , Lövei Gábor L. 
Published: January 2024

AbstractUrbanization is rapidly shaping and transforming natural environments, creating networks of modified land types. These urbanization‐driven modifications lead to local extinctions of several species, but the surviving ones also face numerous novel selection pressures, including exposure to pollutants, habitat alteration, and shifts in food availability and diversity. Based on the assumption that the environmental pool of microorganisms is reduced in urban habitats due to habitat alteration, biodiversity loss, and pollution, we hypothesized that the diversity of bacterial microbiome in digestive tracts of arthropods would be lower in urban than rural habitats. Investigating the gut bacterial communities of a specialist ground beetle, Carabus convexus, in forested rural versus urban habitats by next generation high‐throughput sequencing of the bacterial 16S rRNA gene, we identified 3839 bacterial amplicon sequence variants. The composition of gut bacterial samples did not significantly differ by habitat (rural vs. urban), sex (female vs. male), sampling date (early vs. late spring), or their interaction. The microbiome diversity (evaluated by the Rényi diversity function), however, was higher in rural than urban adults. Our findings demonstrate that urbanization significantly reduced the diversity of the gut bacterial microbiome in C. convexus.
HDA6 modulates Arabidopsis pavement cell morphogenesis through epigenetic suppression of ROP6 GTPase expression and signaling
Authors: Du Xiaojuan , Gao Yingmiao , Zhang Hao , Xu Xiaoyu , Li Ying , Zhao Lifeng , Luo Ming , Wang Hao 
Published: January 2024

Summary

The transcriptional regulation of Rho‐related GTPase from plants (ROPs), which determine cell polarity formation and maintenance during plant development, still remains enigmatic.

In this study, we elucidated the epigenetic mechanism of histone deacetylase HDA6 in transcriptional repression of ROP6 and its impact on cell polarity and morphogenesis in Arabidopsis leaf epidermal pavement cells (PCs).

We found that the hda6 mutant axe1‐4 exhibited impaired jigsaw‐shaped PCs and convoluted leaves. This correlated with disruptions in the spatial organizations of cortical microtubules and filamentous actin, which is integral to PC indentation and lobe formation. Further transcriptional analyses and chromatin immunoprecipitation assay revealed that HDA6 specifically represses ROP6 expression through histone H3K9K14 deacetylation. Importantly, overexpression of dominant negative‐rop6 in axe1‐4 restored interdigitated cell morphology.

Our study unveils HDA6 as a key regulator in Arabidopsis PC morphogenesis through epigenetic suppression of ROP6. It reveals the pivotal role of HDA6 in the transcriptional regulation of ROP6 and provides compelling evidence for the functional interplay between histone deacetylation and ROP6‐mediated cytoskeletal arrangement in the development of interdigitated PCs.
Polyketides/nonribosomal peptides from Streptococcus mutans and their ecological roles in dental biofilm
Authors: Luo Wenxin , Zhang Mengdie , Zhou Xuedong , Xu Xin , Cheng Xingqun 
Published: January 2024

AbstractStreptococcus mutans is the major etiological agent of dental caries in humans. S. mutans overgrowth within dental biofilms can trigger biofilm dysbiosis, ultimately leading to the initiation or progression of dental caries. Polyketides and nonribosomal peptides (PKs/NRPs) are secondary metabolites with complex structures encoded by a cluster of biosynthetic genes. Although not essential for microbial growth, PKs/NRPs play important roles in physiological regulation. Three main classes of hybrid PKs/NRPs in S. mutans have been identified, including mutanobactin, mutanocyclin, and mutanofactin, encoded by the mub, muc, and muf gene clusters, respectively. These three hybrid PKs/NRPs play important roles in environmental adaptation, biofilm formation, and interspecies competition of S. mutans. In this review, we provide an overview of the major hybrid PKs/NRPs of S. mutans, including mutanobactin, mutanocyclin, and mutanofactin and address their ecological roles in dental biofilms. We place specific emphasis on important questions that are yet to be answered to provide novel insights into the cariogenic mechanism of S. mutans and facilitate improved management of dental caries. We highlight that S. mutans PKs/NRPs may be potential novel targets for the prevention and treatment of S. mutans‐induced dental caries. The development of genomics, metabolomics, and mass spectrometry, together with the integration of various databases and bioinformatics tools, will allow the identification and synthesis of other secondary metabolites. Elucidating their physicochemical properties and their ecological roles in oral biofilms is crucial in the identification of novel targets for the ecological management of dental caries.