bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics for the identification of extraprostatic extension with prostate MRI: a systematic review and meta-analysis
Authors: Ponsiglione Andrea , Gambardella Michele , Stanzione Arnaldo , Green Roberta , Cantoni Valeria , Nappi Carmela , Crocetto Felice , Cuocolo Renato , Cuocolo Alberto , Imbriaco Massimo 
Published: November 2023

Abstract
Objectives
Extraprostatic extension (EPE) of prostate cancer (PCa) is predicted using clinical nomograms. Incorporating MRI could represent a leap forward, although poor sensitivity and standardization represent unsolved issues. MRI radiomics has been proposed for EPE prediction. The aim of the study was to systematically review the literature and perform a meta-analysis of MRI-based radiomics approaches for EPE prediction.

Materials and methods
Multiple databases were systematically searched for radiomics studies on EPE detection up to June 2022. Methodological quality was appraised according to Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool and radiomics quality score (RQS). The area under the receiver operating characteristic curves (AUC) was pooled to estimate predictive accuracy. A random-effects model estimated overall effect size. Statistical heterogeneity was assessed with I2 value. Publication bias was evaluated with a funnel plot. Subgroup analyses were performed to explore heterogeneity.

Results
Thirteen studies were included, showing limitations in study design and methodological quality (median RQS 10/36), with high statistical heterogeneity. Pooled AUC for EPE identification was 0.80. In subgroup analysis, test-set and cross-validation-based studies had pooled AUC of 0.85 and 0.89 respectively. Pooled AUC was 0.72 for deep learning (DL)–based and 0.82 for handcrafted radiomics studies and 0.79 and 0.83 for studies with multiple and single scanner data, respectively. Finally, models with the best predictive performance obtained using radiomics features showed pooled AUC of 0.82, while those including clinical data of 0.76.

Conclusion
MRI radiomics–powered models to identify EPE in PCa showed a promising predictive performance overall. However, methodologically robust, clinically driven research evaluating their diagnostic and therapeutic impact is still needed.

Clinical relevance statement
Radiomics might improve the management of prostate cancer patients increasing the value of MRI in the assessment of extraprostatic extension. However, it is imperative that forthcoming research prioritizes confirmation studies and a stronger clinical orientation to solidify these advancements.

Key Points
• MRI radiomics deserves attention as a tool to overcome the limitations of MRI in prostate cancer local staging.
• Pooled AUC was 0.80 for the 13 included studies, with high heterogeneity (84.7%, p < .001), methodological issues, and poor clinical orientation.
• Methodologically robust radiomics research needs to focus on increasing MRI sensitivity and bringing added value to clinical nomograms at patient level.
Elternstreit und Kinderleid: Mit hochstrittigen Eltern in der Praxis
Authors: Weiß Andrea 
Published: November 2023

ZusammenfassungVor nunmehr zehn Jahren, im Februar 2013, trat in Österreich das Kindschafts- und Namensrechts-Änderungsgesetz in Kraft. Darin enthalten ist die Möglichkeit des Gerichts, bei hochstrittigen Scheidungen zur Sicherung des Kindeswohls erforderliche Maßnahmen wie den verpflichtenden Besuch einer angeordneten Familien‑, Eltern- oder Erziehungsberatung nach § 107 Abs. 3 Z 1 Außer-Streit-Gesetz im Pflegschaftsverfahren anzuordnen. Im Qualifikationsprofil sind auch Psychotherapeut:innen als Expert:innengruppe erfasst, weshalb sich dieser Artikel mit den Anwendungsmöglichkeiten und Kooperationen in diesem besonderen Feld auseinandersetzt. Die Indikation, Ziele und Aufgaben der Maßnahme werden vorgestellt. Aus der Praxis folgen Hinweise zur Zusammenarbeit mit den Eltern, Aspekte möglicher Integration der Kinder in den Beratungsprozess und Fragestellungen zur Evaluation der Maßnahme.
Eine neue Methode körperbasierter Psychotherapie mittels Selbstberührungen: Idiopraxie®
Authors: Böckle Markus , Cubasch Peter 
Published: November 2023

ZusammenfassungDie Verbindung von Psyche und Körper ist, wie bei der Behandlung psychosomatischer Erkrankungen, seit Entwicklung der Psychotherapie ein zentrales Thema. In den letzten Jahren zeichnet sich eine deutliche Fokussierung und Erweiterung leibtherapeutischer Intervention ab. Achtsamkeitsbasierte Psychotherapien, Yoga und viele weitere körperzentrierte Psychotherapieformen im Sinne des „Embodiments“ werden immer häufiger von allen psychotherapeutischen Clustern angewendet. In dieses sich entwickelnde Feld fügt sich die Methode Idiopraxie® ein. Sie zielt darauf ab, die körperliche Selbstwahrnehmung und Selbstregulation durch intentionale Selbstberührung zu fördern. Dieser Artikel beschreibt erstmalig Idiopraxie® als innovative leibtherapeutische Intervention in der Psychotherapie. Sie bietet vielversprechende Möglichkeiten, die Integration von Körper und Geist in der therapeutischen Praxis zu verbessern. Ihr Einfluss auf das psychosomatische Wohlbefinden und ihre Übereinstimmung mit zeitgenössischen Trends in der Psychotherapie unterstreichen die Bedeutung weiterer Forschung und Erkundung der Idiopraxie®.
Performance evolution of configurable software systems: an empirical study
Authors: Kaltenecker Christian , Mühlbauer Stefan , Grebhahn Alexander , Siegmund Norbert , Apel Sven 
Published: November 2023

AbstractAs a software system evolves, its performance can improve or degrade over time. Performance evolution is especially delicate in configurable software systems, where performance degradation may manifest only for specific configurations, making it especially hard to spot and fix. Problem. Prior work concentrated mainly on performance-bug detection and root-cause analysis of a single version of a system. The big picture of how performance co-evolves with a system and what role configurability plays is largely unclear. Approach. In an empirical study, we investigate the relation between configurability and performance evolution. Specifically, we analyze a total of 190 releases of 12 configurable real-world systems and examine the extent to which performance changes are specific to particular configurations and whether few or many configuration options cause performance changes. We triangulate our findings by analyzing change logs and commit messages of the respective projects to pin down causes of performance changes. Results. We found that almost every release of every subject system exhibits performance changes in some of their configurations. Notably, the majority of performance changes affects only a subset of the configuration space, and most performance changes are triggered by multiple options (up to 6). In a deeper analysis, we found that a considerable number of releases mention performance changes in the change log and commits: performance changes are reported in $$45\%$$

45
%

and $$69\%$$

69
%

of the releases in the change log and the commit messages, respectively, but only a fraction report the involved configuration options.
Variability of baroreceptor reflex assessed by tilt table test in a patient undergoing pulmonary vein isolation
Authors: Zuk Anna , Piotrowski Roman , Sikorska Agnieszka , Kowalik Ilona , Kulakowski Piotr , Baran Jakub 
Published: November 2023

Abstract
Background
The autonomic nervous system (ANS) plays a significant role in atrial fibrillation (AF). Catheter ablation (CA) affects the ANS balance. The assessment of baroreceptor (BR) function is an established method to measure parasympathetic activity; however, it has been rarely used in patients undergoing CA of AF.

Aims
This study is to assess changes in BR function caused by CA and to compare these changes between two different types of CA: point-by-point radiofrequency (RF) versus cryoballoon (CB).

Methods
In this observational, prospective, single center study, 78 patients (25 females, mean age 58 ± 9) with paroxysmal AF and first CA were included: 39 patients (RF group) and 39 (CB group). The BR function was assessed non-invasively using tilt testing and three parameters: event count (BREC) depicting overall BR activity, slope mean depicting BR sensitivity (BRS), and BR effectiveness index (BEI).

Results
The groups did not differ in clinical or demographic data. Before CA, tilting caused a marked decrease in BR function parameters in the whole study group (BREC (29 ± 14.0–50.0 vs 28 ± 9.0–44.0, p < 0.068), BRS (10.2 ± 7.1–13.2 vs 5.8 ± 4.9–8.5; p < 0.001), and BEI (52.9 ± 39.9–65.5 vs 39.6 ± 23.6–52.1; p < 0.001), supine vs tilting, respectively). These changes were similar in the both groups. After CA, BR function decreased in the whole group (BREC 12.0 ± 3.0–22.0 vs 6.0 ± 3.0–18.0, p = 0.004; BRS 4.8 ± 3.6–6.8 vs 4.0 ± 3.0–5.8, p = 0.014; BEI 18.7 ± 8.3–27.4 vs 12.0 ± 5.1–21.0, p = 0.009). BREC was significantly more decreased in the CB vs RF. Similar trend was noted for BRS and BEI.

Conclusions
CA significantly affects BR function. These changes were more pronounced following CB rather than RF CA.
A Different Vision: Centering Love Not Punishment for Families Affected by Substance Use
Authors: Taylor Kimá Joy 
Published: November 2023

AbstractImproving maternal and child outcomes requires us to understand and deconstruct our country’s historically punitive policies toward pregnant and parenting people who use drugs. We also must build a new system that centers wellness in partnership with individuals directly affected by these policies. From a maternal and child health (MCH) perspective, wellness is defined as parent-infant dyads living in supportive, preserved, and loving families with access to the resources needed for optimal health. To achieve wellness and positive outcomes, all individuals must have equitable access to a full continuum of culturally and linguistically effective, geographically available, evidence-informed, non-punitive, and welcoming health and social services that prioritize family preservation. In addition, to attain transformative and equitable outcomes, advocates for families affected by substance use must focus on implementing and evaluating services and continuously monitoring disaggregated data to ensure inequities are eliminated.
Botryandromyces, a morphology-based genus concept scrutinized by molecular data
Authors: Van Caenegem Warre , De Kesel André , Haelewaters Danny 
Published: November 2023

AbstractLaboulbeniales (Ascomycota) are an order of understudied, biotrophic microfungi uniquely associated with arthropods. More than 2300 species are described but only a fraction of those have been sequenced. Molecular studies have shown that cryptic diversity and phenotypic plasticity are present within the Laboulbeniales. Thus far, all of the 146 genera described in Laboulbeniales have been based on morphological characteristics; features commonly used to delineate genera are the organization of receptacle cells and the number of perithecial outer wall cells. The genus Botryandromyces was erected to accommodate two species, B. heteroceri and B. ornatus (type), which share similar morphological characteristics and are different from other genera in their number of perithecial outer wall cells. Here, we generated sequences of multiple loci (18S, ITS, and 28S) of B. heteroceri and several Laboulbenia species. Our phylogenetic analyses retrieved Botryandromyces within Laboulbenia with high support. The two Botryandromyces species are similar to related Laboulbenia species in their upper receptacle (i.e., cells IV and V). We propose to transfer Botryandromyces ornatus and B. heteroceri to Laboulbenia as L. heteroceri and L. mairei nom. nov., respectively, due to a complicated taxonomic history. These results advocate the use of molecular data and the necessity of an integrative taxonomy approach in the study of Laboulbeniales not only to delineate species, but also to investigate relationships among species, genera, and higher taxa as well as to understand the evolution of morphology in this group of fungi.
Efficient and green oxidation of 2-aminophenol catalyzed by tetra-(p-methoxyphenyl) porphyrin complexes anchored on chitosan in bicarbonate solution
Authors: El-Khalafy Sahar H. , Hassanein Mahmoud T. , Mubarak Ayat A. 
Published: November 2023

AbstractThe study explored the catalytic activities of chitosan-supported tetra (p-methoxyphenyl) porphyrin complexes 1–3 in the heterogeneous activation of the aerobic oxidation dimerization of 2-aminophenol (OAP) to 2-aminophenoxazine-3-one (APX) in the presence of bicarbonate, simulating the function of phenoxazinone enzyme synthase. The oxidation reaction was followed by recording the UV–vis spectra of the reaction mixture with time at λmax 433 nm. All chitosan-supported metalloporphyrin complexes 1–3 exhibited effective catalytic activities for OAP oxidation. Under optimal conditions, the chitosan-supported Cu(II) (Tp-OCH3PP) complex displayed the highest catalytic efficiency. Various parameters influencing the catalytic activity of Cu(II) (Tp-OCH3PP)/CTS 1 were studied. The observed rate constant of OAP oxidation exhibited a direct correlation with the concentration of supported catalyst 1 and followed Michaelis–Menten kinetics, indicating saturation of catalyst sites with increasing OAP concentration. The study investigated the impact of temperature, bicarbonate concentration, dissolved oxygen, and the reaction mechanism. Oxidation reaction of OAP catalyzed by 1 in the presence of nitro blue tetrazolium (NTB) revealed no superoxide anion O2−• was formed as a reactive species during the reaction. The chitosan-supported Cu(II) (Tp-OCH3PP) complex shows high catalytic stability and no significant changes up to the fifth run.
Drought and UV-B radiation modulate Adenanthera pavonina leaf metabolite profile and physiology
Authors: Dias Maria Celeste , Pinto Diana C. G. A. , Costa Maria , Santos Conceição , Silva Artur M. S. 
Published: November 2023

AbstractAdenanthera pavonina is a medicinal species, which economic value depends on the richness of its phytocompounds. Extreme climatic conditions are becoming frequent worldwide, but despite their impact on plant productivity these weather events also modulate plants’ metabolism increasing the production of important phytocompounds. We aimed to characterize the physiological and metabolite adjustments in A. pavonina leaves induced by drought and UV-B radiation. Plants were exposed to drought (DS), UV-B radiation (UV-B), and drought + UV-B (DS + UV-B), and photosynthesis, lipophilic metabolites, and antioxidant status were evaluated. The stress conditions compromised the photosynthetic performance and induced oxidative stress (DS and UV-B plants). However, plants activated protective mechanisms (increased antioxidant activity and flavonoids in all treatments, total phenols in DS and DS + UV-B, and catechols in UV-B and DS + UV-B) and modulated their lipophilic profiles (accumulation of fatty acids and TCA cycle-related metabolites, and reduction of carbohydrates) to cope with the stress. We demonstrate for the first time that DS and UV-B radiation can enrich A. pavonina leaves with antioxidants and fatty acids increasing their medicinal value.
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Authors: Ilg Winfried , Milne Sarah , Schmitz-Hübsch Tanja , Alcock Lisa , Beichert Lukas , Bertini Enrico , Mohamed Ibrahim Norlinah , Dawes Helen , Gomez Christopher M. , Hanagasi Hasmet , Kinnunen Kirsi M. , Minnerop Martina , Németh Andrea H. , Newman Jane , Ng Yi Shiau , Rentz Clara , Samanci Bedia , Shah Vrutangkumar V. , Summa Susanna , Vasco Gessica , McNames James , Horak Fay B. ,   on behalf of the Ataxia Global Initiative (AGI) working group Digital Motor Biomarkers
Published: November 2023

AbstractWith disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.
Aqua Alexandrina and Fragole cistern: characterization of mortars from Roman constructions, Rome (Italy)
Authors: Calzolari Laura , Medeghini Laura , Baiocchi Ilaria , Zanzi Gian Luca , Mignardi Silvano 
Published: November 2023

AbstractAqua Alexandrina is the last aqueduct built by ancient Romans for the city of Rome. At Giovanni Palatucci Park, the archaeological ruins run close to a pre-existent water system, Fragole cistern. This research aims at characterizing mortar samples from both constructions, to identify the materials used and infer about the technological level and the provenance of materials, using a multi-analytical approach. Combining the information obtained through the petrographic investigation of mortar thin sections at optical microscopy and scanning electron microscopy with energy-dispersive X-ray spectroscopy, and X-ray powder diffraction on finely powdered samples and thermogravimetric analysis on the binder fraction, it was possible to attest the presence of both artificial and natural materials with pozzolanic behavior, which conferred hydraulicity to the mortars. The results show that materials are very similar in both constructions, confirming a well-established know-how in the production of hydraulic mortars by the Romans. The volcanic products used as aggregate are identified with two large pyroclastic-flow deposits erupted by the Colli Albani Volcanic District which extensively crop out in the area of Rome: Pozzolane Rosse and Pozzolanelle.
Explainable Artificial Intelligence in Alzheimer’s Disease Classification: A Systematic Review
Authors: Viswan Vimbi , Shaffi Noushath , Mahmud Mufti , Subramanian Karthikeyan , Hajamohideen Faizal 
Published: November 2023

AbstractThe unprecedented growth of computational capabilities in recent years has allowed Artificial Intelligence (AI) models to be developed for medical applications with remarkable results. However, a large number of Computer Aided Diagnosis (CAD) methods powered by AI have limited acceptance and adoption in the medical domain due to the typical blackbox nature of these AI models. Therefore, to facilitate the adoption of these AI models among the medical practitioners, the models' predictions must be explainable and interpretable. The emerging field of explainable AI (XAI) aims to justify the trustworthiness of these models' predictions. This work presents a systematic review of the literature reporting Alzheimer's disease (AD) detection using XAI that were communicated during the last decade. Research questions were carefully formulated to categorise AI models into different conceptual approaches (e.g., Post-hoc, Ante-hoc, Model-Agnostic, Model-Specific, Global, Local etc.) and frameworks (Local Interpretable Model-Agnostic Explanation or LIME, SHapley Additive exPlanations or SHAP, Gradient-weighted Class Activation Mapping or GradCAM, Layer-wise Relevance Propagation or LRP, etc.) of XAI. This categorisation provides broad coverage of the interpretation spectrum from intrinsic (e.g., Model-Specific, Ante-hoc models) to complex patterns (e.g., Model-Agnostic, Post-hoc models) and by taking local explanations to a global scope. Additionally, different forms of interpretations providing in-depth insight into the factors that support the clinical diagnosis of AD are also discussed. Finally, limitations, needs and open challenges of XAI research are outlined with possible prospects of their usage in AD detection.
A gene signature predicting prognosis of patients with lower-grade gliomas receiving temozolomide therapy
Authors: Wan Yanzhi , Li Guangqi , Deng Junyue , Zhu Hong , Ma Xuelei 
Published: November 2023

AbstractTemozolomide (TMZ) has been used as a first-line therapy against lower-grade gliomas (LGGs) combined with other chemotherapy drugs. However, there has been no reliable index predicting TMZ response of patients with LGGs. In this study, we aim to investigate the relationship between gene expressions and the prognosis of TMZ therapy in LGGs. We integrated transcriptome and clinical data of 171 LGGs from the Chinese Glioma Genome Atlas (CGGA). Consensus LASSO Cox regression was used to identify 14 key genes related to different clinical outcomes under TMZ chemotherapy. We constructed and evaluated a risk score based on the 14 genes. Patients with LGGs of lower risk scores (low-risk group) generally had better survival than those LGGs of higher risk scores (high-risk group), which is independent of clinicopathological factors. High-risk patients showed activation of innate and humoral-type immunity. The prognostic contribution of the risk score was validated in an independent validation cohort of 65 patients. Besides, combined with three independent predictors (grade, IDH1 mutation status, and chr1p19q co-deletion status), we further developed a nomogram to predict the benefit of TMZ treatment in LGGs. Our results indicate that a transcriptome-based index can optimize the treatment strategy for patients with LGGs under TMZ therapy.
Port economics, management and policy studies (2009–2020): a bibliometric analysis
Authors: Pallis Athanasios A. , Kladaki Paraskevi , Notteboom Theo 
Published: November 2023

AbstractThis paper analyses published research in port economics, policy and management (port studies) based on examining all relevant academic journal papers published from 2009 to 2020. The systematic review of all 1227 papers relies on quantitative and qualitative bibliometric tools to reveal the structures of the research community (i.e., authors’ country of affiliation, number of authors involved, and international collaboration rates) and the themes and content of port research (i.e., research approaches, units of analysis, ports and commodities examined, levels of research localisation, port markets commonly (not) studied). It also presents a taxonomy of port studies based on a content classification of the themes and sub-themes examined. The paper concludes with a citation analysis that reveals the coherence of port research. The analysis is enriched by comparing the findings with similar studies focusing on the 1997–2008 timeframe. This unique monitoring of a period that expands over a quarter of a century offers a valuable tool for better understanding the research landscape and deciding directions for future research. From a theoretical perspective, the study provides evidence of the rapid transformation of port economics, policy and management into a mature research field.