bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Mutation Sites of CSF3R Responsible for the Clonal Advantage of Chronic Neutrophilic Leukemia
Authors: Altangerel Otgonbat , Zhao Ming Feng , Mao Wu Ri 
Published: November 2023

Objectives: Chronic neutrophilic leukemia (CNL) is a rare, but distinct, entity within myeloproliferative neoplasms, characterized by splenomegaly, sustained mature neutrophilia, and absence of the Philadelphia chromosome. In 2013, oncogenic mutations in colony stimulation factor 3 receptor (CSF3R) were identified in a majority of patients with CNL and it was demonstrated that their downstream signaling was sensitive to known kinase inhibitors. This discovery was then validated with the demonstration of 100% CSF3R mutational frequency (predominately CSF3R-T618I) in strictly CNL as defined by the World Health Organization (WHO). In September 2012, a 67-year-old Chinese man was admitted to the First Central Clinical College of Tianjin Medical University (Tianjin, China) and presented as a case who had fulfilled the WHO diagnostic criteria for CNL with a oncogenic mutation in CSF3R-T618I and also an unreported novel mutation site of CSF3R-H54A Thus, we sought to determine if CSF3R-FL, CSF3R-T618I, CSF3R-H54A mutations have some significance on the molecular pathogenesis of CNL. Methods: In this study, three main experiments were used including plasmid construction, lentiviral packaging system, and Mouse Colony-Forming Unit Assays Using MethoCult™. Results: The establishment of these three experiments was completed successfully. We confirmed the transformation capacity of the CSF3R mutations, especially that CSF3R-T618I was higher than CSF3R-FL Conclusion: This result demonstrates that T618I mutation of CSF3R conferred the clonal advantage of CNL leukemia cells.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS WEBSITE SEBAGAI PENUNJANG PEMBELAJARAN ADMINISTRASI PAJAK KOMPETENSI PPH KELAS XI AKUNTANSI
Authors: Afifah Nur , Listiadi Agung 
Published: November 2023

Ketersediaan media pembelajaran dalam kegiatan belajar harus bisa memberikan kemudahan bagi peserta didik dalam pembelajaran. Penelitian pengembangan yang dilakukan menggunakan model pengembangan ADDIE yang dicetuskan oleh Dick & Carry. Data kualitatif dan kuantitatif akan diperoleh dalam penelitiani ini melalui instrument pengumpulan data berupa kuisioner. Kemudian data yang diperoleh akan diinterprestasikan berdasarkang perhitungan dengan skala likert. Media pembelajaran interaktif berbasis website merupakan produk akhir dari penelitian ini. Sebelum diuji coba, media tersebut menjalani proses telaah dan validasi oleh para ahli media dan materi sebelum diuji cobakan. Sebanyak 20 peserta didik kelas XI Akuntansi melakukan uji coba media. Temuan penelitian ini mengungkapkan bahwa hasil validasi ahli media mendapatkan skor sebesar 98%, ahli materi 94%, dan angket respon peserta didik 98%. Dengan demikian, dapat disimpulkan bahwa media pembelajaran interaktif berbasis website menggunakan Articulate Storyline 3 sangat layak digunakan sebagai penunjang pembelajaran
EFEKTIVITAS PENGGUNAAN MEDIA PEMBELAJARAN ADMINISTRASI PAJAK BERBASIS ARTICULATE STORYLINE TERHADAP HASIL BELAJAR SISWA KELAS XI AKUNTANSI SMKN 1 KEMLAGI
Authors: Wardani Eka Yulia Sukma , Listiadi Agung 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui perbedaan dan efektivitas penggunaan media pembelajaran administrasi pajak berbasis articulate storyline terhadap Hasil belajar siswa kelas XI Akuntansi SMKN I Kemlagi. Pada penelitian sebelumnya media pembelajaran administrasi pajak berbasis articulate storyline ini digunakan untuk memberikan kemudahan proses pembelajaran siswa pada kompetesi PPh pasal 21.
Penelitian ini menggunakan jenis penelitian eksperimen dengan desain penelitian true eksperiment menggunakan pretest – postes control group desain. Penelitian ini dilakukan pada dua kelompok kelas yakni kelas eksperimen dan kelas kontrol, dengan jumlah sampel sebanyak 62 siswa. Hasil uji independent sampel t-tes digunakan untuk melihat adanya perbedaan hasil belajar antara kelas kontrol dan kelas eksperimen, uji ini dilakukan dengan menggunakan data hasil posttest kedua kelas responden, dengan perolehan nilai thitung 16,483 ttabel 1,671 dengan signifikasi 0,000 < 0,05 sehingga keputusan yang dapat diambil adalah H0 ditolak dan Ha diterima atau berbeda signifikan. Untuk mengetahui efektivitas peggunaan media pembelajaran articulate storyline ini menggunakan uji Ngain, dimana diperoleh nilai Ngain 0,75 untuk kelas eksperimen dengan perolehan kriteria tinggi dan 0,24 untuk kelas kontrol yang memiliki kriteria rendah.
Hasil penelitian ini menunjukkan bahwa terdapat perbedaan hasil belajar antara kelas eksperimen selama menggunakan media pembelajaran administrasi pajak berbasis articulate storyline, dengan perolehan nilai signifikasi 0,00 < 0,05 dan kelas kontrol yang masih menggunakan media buku ajar dalam proses pembelajarannya. Serta media pembelajaran administrasi pajak berbasis articulate storyline ini dinyatakan efektif digunakan terhadap hasil belajar siswa
PENGARUH BURNOUT, MEDIA SOSIAL, DAN PENGGUNAAAN MEDIA PEMBELAJARAN TERHADAP HASIL BELAJAR AKUNTANSI DASAR PADA SISWA KELAS X PROGRAM KEAHLIAN AKL SMK YAPALIS KRIAN
Authors: Nadiyah Faza Achsanti , Arif Amirul 
Published: November 2023

Belajar merupakan perubahan tingkah laku sebagai akibat dari adanya interaksi antara stimulus dan respon. Salah satu indikator yang dapat digunakan untuk menentukan keberhasilan dalam proses pembelajaran adalah hasil belajar siswa. Hasil belajar akuntansi dasar siswa kelas X AKL SMK Yapalis Krian dapat menjadi lebih baik apabila dalamproses pembelajaran memperhatikan faktor-faktor yang mempengaruhi hasil belajar. Tujuan penelitian ini yaitu mengetahui pengaruh burnout, media sosial, dan penggunaan media pembelajaran terhadap hasil belajar akuntansi dasar pada siswa kelas X Program Keahlian AKL SMK Yapalis Krian tahun ajaran 2022/2023. Jenis penelitian ini kuantitatif ex-postfacto. Teknik pengambilan sampel menggunakan random sampling. Teknik pengumpulan data yang digunakan yaitu kuesioner dan dokumentasi. Teknik analisis data menggunakan regresi linier berganda dengan bantuan aplikasi SPSS 25 yang terdiri atas uji asumsi klasik dan hipotesis. Hasil penelitian menunjukkan (1) terdapat pengaruh burnout, media sosial, dan penggunaan media pembelajaran secara simultan terhadap hasil belajar akuntansi dasar pada siswa kelas X SMK Yapalis Krian dengan nilai signifikansi sebesar 0,000 < 0,05 dan f hitung 29,541 > 2,705; Dapat disimpulkan bahwasannya, jika burnout, media sosial, dan penggunaan media pembelajaran secara bersama-sama mengalami peningkatan maka hasil belajar siswa juga akan meningkat. (2) terdapat pengaruh negatifburnout terhadap hasil belajar akuntansi dasar pada siswa kelas X SMK Yapalis Krian dengan nilai signifikansi sebesar 0,022 < 0,05 dan f hitung 2,327 < 1,987; Dapat disimpulkan bahwasannya jika tingkat burnout-nya tinggi maka hasil belajarnya menurun, sebaliknya jika tingkat burnout-nya rendah maka hasil belajarnya meningkat. (3) terdapat pengaruh negatif media sosial terhadap hasil belajar akuntansi dasar pada siswa kelas X SMK Yapalis Krian dengan nilai signifikansi sebesar 0,000 < 0,05 dan f hitung 4,628 < 1,987; Dapat disimpulkan bahwasannya jika tingkat penggunaan media sosial tinggi maka hasil belajarnya menurun, sebaliknya jika tingkat penggunaan media sosial rendah maka hasil belajarnya meningkat. (4) terdapat pengaruh media pembelajaran terhadap hasil belajar akuntansi dasar pada siswa kelas X SMK Yapalis Krian dengan nilai signifikansi sebesar 0,000 < 0,05 dan f hitung 7,312 > 1,987. Dapat disimpulkan bahwasannya jika penggunaan media pembelajaran tinggi maka hasil belajar siswa juga semakin meningkat.
DINAMIKA PENGAMBILAN KEPUTUSAN KARIER MENJADI CALON GURU : PERSEPSI PENDIDIKAN PROFESI GURU VS DUKUNGAN KELUARGA
Authors: Nurfauziah Tanti , Gumilar Gugum , Afriza Edi Fitriana 
Published: November 2023

Mahasiswa yang mendaftar atau yang masuk ke jurusan pendidikan ekonomi belum sepenuhnya memiliki keinginan menjadi guru. Karena karier menjadi guru khususnya di Indonesia tidak memiliki kepastian karier yang jelas seperti lamanya karier atau masa tambahan studinya, sehingga membingungkan mahasiswa. Hal ini menyebabkan bahwa mereka tidak memiliki perencanaan karier yang baik sehingga berimbas pada keputusan karier yang kurang matang. Fokus penelitian untuk mengetahui pengaruh Persepsi Pendidikan Profesi Guru, Dukungan Keluarga terhadap Pengambilan Keputusan Karier Menjadi Calon Guru baik secara parsial maupun simultan. Cara menyelesaikan penelitian dengan exsplanatory reserach. Mahasiswa pendidikan Ekonomi dijadikan sebagai populasi berjumlah 219 orang dengan teknik sampling jenuh sehingga semua diambil jadi responden. Hasil penelitian ini menunjukan terdapat pengaruh yang signifikan secara parsial dan simultan antara persepsi pendidikan profesi guru dan dukungan keluarga terhadap pengambilan keputusan karier menjadi calon guru
Fracaso y experiencia del límite. Naturalismo metodológico y crisis escéptica en el Tratado de D. Hume
Authors: Yrigoyen Carpintero Elena 
Published: November 2023

¿Qué significa "fracasar" para un naturalista metodológico? ¿Está éste abocado al escepticismo, y es este un fracaso? Para responder a estas preguntas, realizaré (1) un análisis de lo que se considera "naturalismo" en Hume, desde el que analizaré (2) la crisis escéptica narrada en la conclusión del Libro I del Tratado. Allí defenderé que la metafórica utilizada, engarzada con el concepto de fracaso, permite dos lecturas: una que une necesariamente naturalismo metodológico y escepticismo mitigado, y otra que no. No obstante, concluiré que en ambos casos se dibuja una misma experiencia de límite que permite construir ciencia y filosofía no-excepcionalistas.
Cold stimulation is feasible and has limited aversiveness in healthy, pain-free dogs
Authors: Wittenberg-Voges Liza , Delarocque Julien , Kästner Sabine BR , Schütter Alexandra 
Published: November 2023

Abstract

OBJECTIVE
The study aimed to evaluate the applicability and repeatability of cold stimulation in dogs.

ANIMALS
10 healthy Beagle dogs were used in a blinded cross-over experiment.

METHODS
Measurements were performed in triplicate at 4 skin locations. The probe was manually placed, and temperature decreased (32 to 10 °C) at different cooling rates (0.5, 1, and 5 °C second−1) and latency was measured (11 °C for 60 seconds). Stimulations were discontinued when avoidance reactions were detected. Thermal threshold or time-to-reaction were recorded. Experiments were performed 3 times per animal in weeks 1 (Exp1), 2 (Exp2), and 5 (Exp3). Feasibility of cold stimulation was scored (0–5). Data were analyzed with mixed logistic regression.

RESULTS
No significant differences in number of avoidance reactions between cooling-rates were detected. Significantly more reactions (P < .001) were observed during Exp1 compared to Exp2 and Exp3. Thermal thresholds were 13 ± 2.6 °C, 17.7 ± 4 °C and 16.3 ± 4.6 °C for 5, 0.5 and 1 °C second−1, respectively. Latency to the reaction was determinable in 37% of measurements. The mean time-to-reaction was 13 ± 11 seconds. In 85% of measurements, a feasibility score of 0 (best feasibility) was assigned.

CLINICAL RELEVANCE
The method is easily applicable and well tolerated, but habituation could not be excluded. Overall, the aversiveness of cold stimulation in healthy dogs is limited and it is not possible to recommend a specific protocol. In future studies, it needs to be determined if the aversiveness of cold stimulation is increased in diseased dogs.
Knowledge of Students of Selected Fields at the Medical University of Lodz on Basic Resuscitation Procedures
Authors: Tchórzewski Jakub , Tchórzewska Karolina , Rzeźnicki Adam , Warczyńska Anna , Cichońska-Rzeźnicka Dominika , Krakowiak Jan 
Published: November 2023

Abstract

Background
Sudden cardiac arrest (SCA) is a sudden medical condition in which the mechanical function of the heart is impaired and consequently ceases. It is the most common cause of human death in Europe. In order to increase survival rates, it is essential to spread knowledge among the public about life-saving techniques. Medical students, as a specific health-related group, should be familiar with current life-threatening emergency management regimens.

Objective
The aim of the study was to assess the knowledge of students of selected faculties at the Medical University of Lodz on basic resuscitation procedures (BLS – Basic Life Support).

Material and methods
Online survey questionnaire consisting of 25 questions developed by the study authors. The study involved 327 students of selected faculties: medicine, nursing, paramedicine, public health at the Medical University of Lodz. Inclusion criteria for the study: age >= 18 years, status as a student of the aforementioned faculties at the Medical University of Lodz, informed consent to participate in the study.

Results
80.7% (264) of the students were familiar with the management algorithm: 85.6% (89) of medical students, 79.8% (67) of nursing students, 81.0% (60) of paramedic students, and 71.6% (48) of public health students; 81.5% (145) of those familiar with the algorithm were female, and 79.9% (119) were male students. 92.3% of medical students, 82.1% of nursing students, 90.3% of paramedic students and 64.1% of public health students had knowledge of AEDs. Among the respondents, the most common sources of knowledge about BLS were the medical school classes (68.5% (224)) and the Internet (24.16% (79)).

Conclusions
The knowledge of the students of selected courses of the Medical University of Lodz was satisfactory. The majority of students knew the procedure algorithm and emergency numbers. The main source of BLS knowledge for students were classes at the medical university and the Internet. The process of educating medical students and the entire society about BLS should be continuously pursued.
FLOURISHING BAGI MAHASISWA BIMBINGAN DAN KONSELING SEBAGAI CALON HELPER
Authors: Herdiansyah Diki , Nurul Hanifah Puteri  
Published: November 2023

Flourishing is when individuals achieve complete mental health so they have positive psychological, social and emotional functioning so they can control themselves. This is important for potential helpers because when they develop themselves, they will already have positive psychological, social and emotional functions. So this research aims to determine the importance of flourishing for guidance and counseling students as prospective students. The method used in this research is a literature review by examining journals found on Google Scholar between 2017-2023 with the keyword "flourishing". So we obtained seven relevant journals that could answer the researchers' questions. The results of this research show the importance of flourishing for students, especially prospective helpers, and the need for support for students to achieve flourishing within themselves by creating a conducive environment and providing students with optimal opportunities to have academic and social support, so that students become potential helpers. mentally healthy with flourishing within them. The findings in this research can become study material for further research to empirically test the level of flourishing in guidance and counseling students as potential helpers.
Key: Flourishing, guidance and counseling students, helper.
Carbonate Ramp Facies and Porosity Recognition: Case Study of the Late Albian-Early Cenomanian Mauddud Formation in Ratawi Oilfield, Southern Iraq
Authors: Hussain Salah A. , Ibrahim Yasamin K. 
Published: November 2023

The carbonate ramp facies of the Late Albian-Early Cenomanian Mauddud Formation were studied in the Ratawi Oilfield, Basra Governorate, south of Iraq using integrated borehole data set that included, core and cutting samples in three drilled wells to analyze the petrography of the Mauddud Formation, two hundred and eighty-one (281) thin sections were prepared and examined for the three selected wells. The results show that the formation is composed of light grey dolomitized limestone and pseudo-oolitic creamy limestone with green to bluish shale. The petrographic observations results show four facies’ associations in the Mauddud Formation. These include: Mid–Ramp environment which is represented by Argillaceous mudstone microfacies, Argillaceous wackestone microfacies and orbitolinid wackestone microfacies; the shallow open marine environment which is assimilated by foraminiferal wackestone microfacies and foraminiferal packstone microfacies; a restricted marine environment that represented by bioclastic fossiliferous wackestone microfacies and miliolid wackestone microfacies and Shoal environment is represented by bioclastic packstone microfacies, bioclastic grainstone microfacies, peloidal foraminiferal pack-grainstone microfacies, and peloidal packstone-grainstone microfacies with diverse skeletal grains. The porosity includes Vuggy, Interparticle, Intraparticle and Fracture porosity.
Oscillation of the Solutions for Hematopoiesis Models
Authors: Hadeed Iman Sabeeh , Mohamad Hussain Ali 
Published: November 2023

In this paper, the oscillation of a Hematopoiesis model in both cases delay and non-delay are discussed. The place and are continuous pstive -rdic functions. In the nn-dlay cse, we will exhibit that a nonlinear differential equation of hematopoiesis model has a global attractor for all different pstive solutions. Also, in the delay case, the sufficient conditions for the oscillation of all pstive solutions of it aboutare presented and we establish sufficient cnditions for the global attractive of. To illustrate the obtained results some examples are given.
On a Subclass of Meromorphic Univalent Functions With Fixed Second Coefficientsassociated with q-Differed Operator
Authors: Mahmood Zena Hameed , Jassim Kassim Abdulhameed 
Published: November 2023

The main object of this article is to study and introduce a subclass of meromorphic univalent functions with fixed second positive defined by q-differed operator. Coefficient bounds, distortion and Growth theorems, and various are the obtained results.
New Class of Conjugate Gradient Methods for Removing Impulse Noise Images
Authors: Abbo Hameed , Hassan Basim 
Published: November 2023

The conjugate coefficient optimal is the very establishment of a variety of conjugate gradient methods. This paper proposes a new class coefficient of conjugate gradient (CG) methods for impulse noise removal, which is based on the quadratic model. Our proposed method ensures descent independent of the accuracy of the line search and it is globally convergent under some conditions, Numerical experiments are also presented for the impulse noise removal in images.
Portrait of Personality and its Study by Psychosemantics
Authors: Gaivoronskaya Aleksandra Aleksandrovna 
Published: November 2023

The subject of the study is a portrait of a personality. Psychological massage is a detailed description of personality characteristics. The unit of personality analysis is the personal meaning. In the aggregate of other meanings, personal meaning forms a hierarchical structure that can be rebuilt in the course of life and, depending on experience, transform the content of meanings in this hierarchy. The object of research is a portrait of a personality studied by methods of psychosemantics to identify the structure, functioning of a system of values, methods of categorization describing a portrait of a personality. Psychosemantic methods are aimed at reconstructing implicit theories of personality and solve the following tasks: connecting the studied meaning of this phenomenon with other meanings, systems of meanings, highlighting and interpreting the most significant among these connections. The psychosemantic approach to the portrait of a personality is a description of a psychological (semantic) structure that contains properties-signs that can be used to characterize a personality. This structure is formed by various types of values "classifying" this construct as a "psychological portrait" The main conclusions of the study are:1) the use of psychosemantic tools for the interpretation of the "personality portrait" contributes to the disclosure of the characteristics of this phenomenon, namely, how the levels of categorization identified during the study correlate with significant topics describing the psychological portrait; 2) a portrait of a personality is a complex characteristic that reflects the inner world, the orientation of the personality and is a tool for studying a person. The novelty of the research lies in the study of implicit theories of drawing up a psychological portrait, resulting in a model of a psychological portrait.
PEMANFAATAN ROTAN SEBAGAI BAHAN KERAJINAN ANYAMAN MASYARAKAT DUSUN SUNGAI HIJAU DESA TELUK KEBAU KECAMATAN NANGA MAHAP KABUPATEN SEKADAU (Utilization of rattan as a woven craft material the community of Sungai Hijau Hamlet Teluk Kebau Village Nanga Mahap District Sekadau Regency )
Authors: M Iskandar A , Hendi Hendi , Thamrin Edy , Munadian Munadian 
Published: November 2023

Indonesian forests have abundant non-timber forest products. In Sungai Hijau Hamlet, rattan is potential biological wealth. Rattan is usually used by the community for woven crafts, rigging, and other purposes. This study aims to record the types of wicker produced by the community of Sungai Hijau Hamlet, Teluk Kebau Village, Nanga Mahap District, Sekadau Regency. The research methods are carried out through surveys and interviews. Data retrieval uses purposive sampling techniques to determine respondents. The results show that there are 7 types of rattan commonly used by the community of Sungai Hijau Hamlet: Korthalsia rigida Blume, Korthalsia echinometra Beccari, Calamus javensis Blume, Calamus caesius Blume, Calamus trachycoleus Beccari, Daemonorops geniculata (Griff) Mart, and Daemonorops angustifolia Mart. From 7 types of rattan, 9 are woven: atongk, penengkeingk, tikau lipat, impak, nayak, ogak, bakol, tengouk, and ontangk. All types of woven products are used as support in work activities and to meet daily needs.Keywords: Non-timber Forest Product, Rattan Utilization, Woven.AbstrakHutan Indonesia mempunyai hasil hutan bukan kayu yang cukup melimpah. Di Dusun Sungai Hijau rotan adalah potensi kekayaan hayati. Rotan biasanya digunakan oleh masyarakat sebagai bahan kerajinan anyaman, tali-temali, dan untuk keperluan lainnya. Penelitian ini bertujuan untuk mendata jenis rotan dan mendeskripsikan jenis anyaman yang dihasilkan oleh masyarakat Dusun Sungai Hijau, Desa Teluk Kebau, Kecamatan Nanga Mahap Kabupaten Sekadau. Motode penelitian dilakukan dengan survei dan wawancara. Pengambilan data menggunakan teknik purposive sampling untuk menentukan responden. Hasilnya menunjukan bahwa ada 7 jenis rotan yang biasa digunakan oleh masyarakat Dusun Sungai Hijau yaitu: Korthalsia rigida Blume, Korthalsia echinometra Beccari, Calamus javensis Blume, Calamus caesius Blume, Calamus trachycoleus Beccari, Daemonorops Geniculata (Griff) Mart, dan Daemonorops angustifolia mart. Dari 7 jenis rotan menghasilkan 9 bentuk anyaman yaitu atongk, penengkeingk, tikau lipat, impak, nayak, ogak, bakol, tengouk, dan ontangk. Semua jenis produk anyaman digunakan sebagai penunjang dalam aktifitas bekerja dan untuk memenuhi kebutuhan sehari-hari.Kata kunci: Hasil Hutan Bukan Kayu, Pemanfaatan Rotan, Anyaman,