bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental, social, and governance disclosure and capital market mispricing
Authors: Wang Bin , Wang Fangzheng , Kong Xiaofei , Liu Li , Liu Chunlu 
Published: December 2023

AbstractWith the development of sustainability, ESG information has become a key factor for investors in capital market, but researches on the relationship between ESG disclosure and capital market efficiency has not been clear. Using the data of Chinese A‐share listed companies from 2011 to 2019, this study examined the relationship between ESG disclosure and market mispricing. The results showed that the higher ESG disclosure with lower level of mispricing, which was also verified in both the overvalued and undervalued samples. The test of environmental (E), social (S), and, governance (G) showed that environmental disclosure can restrain the over‐valuation, social disclosure can mitigate the under‐valuation, and corporate governance disclosure has no significant impact on the mispricing. In addition, this paper identified the effect of ESG disclosure on market mispricing by using exogenous market fluctuation. Furtherly, mechanism analysis results showed that ESG disclosure can affect pricing deviation through signaling and supervision effects.
Abundance, biomass and species richness of macrozoobenthos along an intertidal elevation gradient
Authors: Dewenter Jana , Yong Joanne , Schupp Peter J. , Lõhmus Kertu , Kröncke Ingrid , Moorthi Stefanie , Pieck Daniela , Kuczynski Lucie , Rohde Sven 
Published: December 2023

AbstractEcology aims to comprehend species distribution and its interaction with environmental factors, from global to local scales. While global environmental changes affect marine biodiversity, understanding the drivers at smaller scales remains crucial. Tidal flats can be found on most of the world's coastlines and are particularly vulnerable to anthropogenic disturbances. They are important transient ecosystems between terrestrial and marine ecosystems, and their biodiversity provides important ecosystem services. Owing to this unique, terrestrial–marine transition, strong environmental gradients of elevation, sediment composition and food availability prevail. Here, we investigated which regional and local environmental factors drive the spatio‐temporal dynamics of macrozoobenthos communities on back‐barrier tidal flats in the East Frisian Wadden Sea. On the regional level, we found that species composition changed significantly from west to east on the East Frisian islands and that total abundance and species richness decreased from west to east. On the local abiotic level, we found that macrozoobenthos biomass decreased with higher elevation towards the salt marsh and that the total abundance of organisms in the sediment significantly increased with increasing mud content, while biodiversity and biomass were not changing significantly. In contrast to expectations, increasing Chl a availability as a measure of primary productivity did not result in changes in abundance, biomass or biodiversity, but extremely high total organic carbon (TOC) content was associated with a decrease in biomass and biodiversity. In conclusion, we found regional and local relationships that are similar to those observed in previous studies on macrozoobenthos in the Wadden Sea. Macrozoobenthos biomass, abundance and biodiversity are interrelated in a complex way with the physical, abiotic and biotic processes in and above the sediment.
Characteristics, correlates of burden and support service use of a help‐seeking carers of loved ones with an eating disorder
Authors: Pehlivan Melissa J. , Rodgers Bethany , Schlage Jasmin , Maguire Sarah , Miskovic‐Wheatley Jane 
Published: December 2023

AbstractObjectiveCarers, vital in the care of individuals with an eating disorder (ED), experience substantial caregiving burden and unmet needs. This study aims to identify factors which contribute to the burden experienced by carers of a loved one with an ED and their support service usage.MethodCarers (N = 245) completed an online questionnaire assessing demographic, carer‐specific, individual and ED factors. Multivariate relationships with caregiving burden were examined using forwards elimination to produce a parsimonious model of carer burden.ResultsThe final model, consisting of caregiving factors (e.g., relationship type, skills), carer mental health) and loved one wellbeing (i.e., purging symptoms, depression/self‐harm/suicidality) explained a large proportion (62%) of the variance in carers' burden. Carer mental health, caregiving skills and relationship type (e.g., parent, spouse, sibling) were key predictors of carers' burden. Nearly a third of carers had not used any carer support services, yet most carers expressed an interest in such services.ConclusionCaregiving burden is determined by experiences and skills of the carer as well as the person they are caring for. Carer support services should continue to address the general wellbeing of carers and caregiver skills. Research into the barriers to carer support uptake is needed.
A secure blockchain framework for the internet of medical things
Authors: Sharma Aashima , Kaur Sanmeet , Singh Maninder 
Published: December 2023

AbstractTechnological advancements in the Internet of Medical Things (IoMT) enable medical services to provide incredibly challenging real‐time functions. The proliferation of health sensors has improved patient monitoring, both for patient care and medical purposes, giving professionals more data for early diagnosis and treatment recommendations. Privacy and security are critical considerations for collecting and transferring data from these heterogeneous sensors across the database and the IoT network. This study leverages blockchain technology to improve Electronic Health Record (EHR) privacy and security. This article proposes a novel decentralized architecture using IoT and Blockchain technology for storing EHR and monitoring real‐time patient data. The proposed patient‐centric framework and architecture offer a straightforward solution that fulfills data integrity and anonymity and meets the data interoperability demands. Self‐contained encryption–decryption and primitive cryptographic techniques enhance the system's security. The proposed study models IoT health sensors such as body temperature, pulse rate, spO2, and Electromyogram (EMG) in a blockchain‐based IoT framework. The proposed system has been evaluated to determine that it can process and store Remote Patient Monitoring (RPM) data with encouraging results. The article provides performance, security, and threat analysis to contribute toward a robust, secure, and smart healthcare system using metrics such as latency, throughput, IoT sensor activity, and resource usage. Experimental results present that the proposed method beats the standard healthcare system regarding service quality and patient data monitoring.
A novel nanobody broadly neutralizes SARS‐CoV‐2 via induction of spike trimer dimers conformation
Authors: Yang Yang , Zhang Junfang , Zhang Shengnan , Zhang Chenhui , Shen Chenguang , Song Shuo , Wang Yanqun , Peng Yun , Gong Xiaohua , Dai Jun , Xie Chongwei , Khrustaleva Tatyana Aleksandrovna , Khrustalev Vladislav Victorovich , Huo Yongting , Lu Di , Yao Da , Zhao Jincun , Liu Yingxia , Lu Hongzhou 
Published: December 2023

AbstractThe ongoing mutations of the SARS‐CoV‐2 pose serious challenges to the efficacy of the available antiviral drugs, and new drugs with fantastic efficacy are always deserved investigation. Here, a nanobody called IBT‐CoV144 is reported, which exhibits broad neutralizing activity against SARS‐CoV‐2 by inducing the conformation of spike trimer dimers. IBT‐CoV144 was isolated from an immunized alpaca using the RBD of wild‐type SARS‐CoV‐2, and it showed strong cross‐reactive binding and neutralizing potency against diverse SARS‐CoV‐2 variants, including Omicron subvariants. Moreover, the prophylactically and therapeutically intranasal administration of IBT‐CoV144 confers fantastic protective efficacy against the challenge of Omicron BA.1 variant in BALB/c mice model. The structure analysis of the complex between spike (S) protein, conducted using Cryo‐EM, revealed a special conformation known as the trimer dimers. This conformation is formed by two trimers, with six RBDs in the “up” state and bound by six VHHs. IBT‐CoV144 binds to the lateral region of the RBD on the S protein, facilitating the aggregation of S proteins. This aggregation results in steric hindrance, which disrupts the recognition of the virus by ACE2 on host cells. The discovery of IBT‐CoV144 will provide valuable insights for the development of advanced therapeutics and the design of next‐generation vaccines.
Strategies for Direct, Transition Metal‐Free Addition of Nitrogen Synthons to Alkenes
Authors: Hemric Brett N. , Garcia Thalia A. , Barni Adriana E. 
Published: December 2023

AbstractThe incorporation of nitrogen into small molecules is one of the highest‐demanded transformations in modern synthetic chemistry. Alkene difunctionalization and aziridination offer desirable approaches to the incorporation of these amino synthons from feedstock precursors. Although amino groups can be added to alkenes following alkene reaction with an initiation reagent, the most desirable approach involves direct addition of the nitrogen group to the alkene, allowing for a range of possible secondary functionalization outcomes. Although many of these strategies have been accomplished through the use of transition metals, the utility of a transition metal‐free approach is still at the forefront of synthetic chemistry, both in development and demand. This review aims to present a comprehensive review of the history and current state‐of‐the‐art in the transition metal‐free, direct addition of nitrogen to alkenes.
Hydroalkylation of 1,1‐Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents
Authors: Chaisan Nattawadee , Yew Kun Tan Eugene , Chiba Shunsuke 
Published: December 2023

AbstractA method for the hydroalkylation of 1,1‐diarylalkenes has been developed using magnesium hydride (MgH2) generated in situ by the solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1‐diarylalkenes with MgH2 to generate 1,1‐diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products.
Debt restructurings, debt grifting and the limits of contractualism
Authors: McCormack Gerard 
Published: December 2023

AbstractThis article critically examines corporate restructuring plans and schemes in the United Kingdom and United States and third‐party releases in the context of such corporate restructurings. So far, the practice has been more extensively examined in the United States rather than the United Kingdom and the practice has been castigated as ‘debt grifting’, that is, third parties getting the benefit of a bankruptcy discharge without going through the formal bankruptcy process. This article acknowledges some of these criticisms. It also suggests that, if third‐party releases become more widespread in the United Kingdom, this is likely to militate against the success of the United Kingdom as an international corporate restructuring venue. This is particularly the case if the underlying debt is disputed or gives rise to social or political controversy. The article is divided into five parts. After the first introductory part, the second part will examine how debts are restructured in the large corporate context in the United Kingdom and how third‐party releases are important for this endeavour. The third part will examine the equivalent position in the United States. The fourth part explores how the restructuring solutions currently on the table push up against the limits of contractually derived solutions. The final part concludes.
Enhancing resilience and well‐being among low‐SES populations: The mediating effect of community resources
Authors: Zanbar Lea 
Published: December 2023

AbstractResidents of low‐socioeconomic status (SES) neighborhoods suffer from social, economic, and health problems and high exposure to crime and neglect. Based on the social cure approach, the study aimed to examine whether community resources are associated with resilience and well‐being, and whether they mediate the associations between personal resources and these outcomes. The moderating effect of participating in community activity was also investigated. A total of 400 residents of low‐SES communities, 200 of whom were community activists, completed questionnaires measuring personal resources, community resources, and the outcomes (resilience, well‐being). Structural equation modeling revealed the mediating role of community resources. Moderation analysis indicated that different paths led to the outcomes among activists and nonactivists. The results indicate that personal resources alone do not substantially enhance welfare in low‐SES communities, but should be channeled through community belonging and commitment. Moreover, professionals working with these communities should take into account the distinctions between activists and nonactivists.
A tale of two islands: tectonic and orbital controls on marine terrace reoccupation, Channel Islands National Park, California, USA
Authors: Muhs Daniel R. , Groves Lindsey T. , Simmons Kathleen R. , Schumann R. Randall , DeVogel Stephen B. 
Published: December 2023

AbstractIn areas of low uplift rate on the Pacific Coast of North America, reoccupation of emergent marine terraces by later high sea‐stands has been hypothesised to explain the existence of thermally anomalous fauna (mixtures of warm and cool species) of last interglacial age. If uplift rates have been low for much of the Quaternary, it follows that higher (older) terraces should also show evidence of reoccupation. Strontium isotope analyses of fossils from a high‐elevation marine terrace on Anacapa Island, California, yield ages ranging from ~2.4–2.3 Ma to ~1.4–1.5 Ma. These results indicate that terrace reoccupation and fossil mixing on Anacapa Island could have taken place over several interglacial periods in the early Pleistocene. Terrace reoccupation over this time period is likely a function of both a low uplift rate and the timing of orbital forcing of glacial–interglacial cycles. Climate change in the early Pleistocene was modulated by the 41 ka obliquity cycle, and glacial–interglacial cycles were much shorter than later in the Pleistocene. Nearby San Miguel Island also has evidence of terrace reoccupation, with Sr isotope ages of shells from several high‐elevation terraces ranging from ~1.21–1.25 Ma to ~0.43–0.50 Ma. However, the frequency of terrace reoccupation was lower than on Anacapa Island. The uplift rate of San Miguel Island is higher than that of Anacapa Island and terraces formed when glacial–interglacial cycles were longer. The frequency of marine terrace reoccupation is controlled by the rate of tectonic uplift and the timing of orbital forcing of sea level change during glacial–interglacial cycles.
Moving into the modern era of molecular classification for endometrial cancer
Authors: Dagher Christian , Liu Ying L. , Mueller Jennifer J. , Weigelt Britta 
Published: December 2023

AbstractThe molecular subtypes of endometrial carcinoma (EC) were first described by The Cancer Genome Atlas (TCGA) a decade ago. Using surrogate approaches, the molecular classification has been demonstrated to be prognostic across EC patients and to have predictive implications. Starting in 2020, the molecular classification has been incorporated into multiple guidelines as part of the risk assessment and most recently into the International Federation of Gynecology and Obstetrics (FIGO) staging. This review article discusses the implementation of the EC molecular classification into clinical practice, the therapeutic implications, and the molecular and clinical heterogeneity of the EC molecular subtypes.
Symmetrical placement of bilateral percutaneous bone‐anchored hearing systems via guide‐marker
Authors: Garcia Renata Tadeu Ramirez , dos Santos Antonio Carlos , Danieli Fabiana , Hyppolito Miguel Angelo 
Published: December 2023

AbstractObjectivesTo investigate the use of a novel technique to estimate the symmetrical placement of percutaneous bone‐anchored hearing systems (BAHS) with a guide‐marker in patients undergoing bilateral surgery with this device.Study DesignProspective cohort study.MethodsA guide‐marker and anatomical landmarks were used to estimate the implant placement and transferred to the contralateral ear in 12 subjects eligible for bilateral BAHS surgery. To investigate the bilateral symmetry, preoperative tri‐dimensional (3D) computed tomography (CT) image reconstruction was used to compare the distances between the mandibular condyle and implant placement estimation (mandible‐implant distance) in both the right and left ears of the subjects.ResultsThe guide‐marker could be used to estimate the bilateral implant placement in all subjects included in this study, simply and easily, including one subject with craniofacial malformation. The mean mandible‐implant distances were 5.37 and 5.38 cm, in the right and left ears of the subjects, respectively, and no differences were observed between them, thereby indicating optimal bilateral symmetry.ConclusionThe use of the guide‐marker proved to be an effective tool to provide symmetrical placement of bilateral BAHS. We propose a novel method employing a simple guide‐marker and tracing based on symmetrical anatomical landmarks to achieve precise placement and optimal symmetry and which may be easily adopted in the surgical routine of BAHS.Level of Evidence3.
Uncertainty sources for measurable ocean carbonate chemistry variables
Authors: Carter Brendan R. , Sharp Jonathan D. , Dickson Andrew G. , Álvarez Marta , Fong Michael B. , García‐Ibáñez Maribel I. , Woosley Ryan J. , Takeshita Yuichiro , Barbero Leticia , Byrne Robert H. , Cai Wei‐Jun , Chierici Melissa , Clegg Simon L. , Easley Regina A. , Fassbender Andrea J. , Fleger Kalla L. , Li Xinyu , Martín‐Mayor Macarena , Schockman Katelyn M. , Wang Zhaohui Aleck 
Published: December 2023

AbstractThe ocean carbonate system is critical to monitor because it plays a major role in regulating Earth's climate and marine ecosystems. It is monitored using a variety of measurements, and it is commonly understood that all components of seawater carbonate chemistry can be calculated when at least two carbonate system variables are measured. However, several recent studies have highlighted systematic discrepancies between calculated and directly measured carbonate chemistry variables and these discrepancies have large implications for efforts to measure and quantify the changing ocean carbon cycle. Given this, the Ocean Carbonate System Intercomparison Forum (OCSIF) was formed as a working group through the Ocean Carbon and Biogeochemistry program to coordinate and recommend research to quantify and/or reduce uncertainties and disagreements in measurable seawater carbonate system measurements and calculations, identify unknown or overlooked sources of these uncertainties, and provide recommendations for making progress on community efforts despite these uncertainties. With this paper we aim to (1) summarize recent progress toward quantifying and reducing carbonate system uncertainties; (2) advocate for research to further reduce and better quantify carbonate system measurement uncertainties; (3) present a small amount of new data, metadata, and analysis related to uncertainties in carbonate system measurements; and (4) restate and explain the rationales behind several OCSIF recommendations. We focus on open ocean carbonate chemistry, and caution that the considerations we discuss become further complicated in coastal, estuarine, and sedimentary environments.
Global solutions to the rotating Navier–Stokes equations with large data in the critical Fourier–Besov spaces
Authors: Fujii Mikihiro 
Published: December 2023

AbstractWe consider the initial value problem for the 3D incompressible Navier–Stokes equations with the Coriolis force. The aim of this paper is to prove the existence of a unique global solution with arbitrarily large initial data in the scaling critical Fourier–Besov spaces (, ), provided that the size of the Coriolis parameter is sufficiently large. Moreover, if the initial data additionally belong to the scaling sub‐critical spaces, we obtain an explicit relationship between the initial data and the Coriolis force, which ensures the existence of a unique global solution.
Gut microbiota in the short‐beaked echidna (Tachyglossus Aculeatus) shows stability across gestation
Authors: Buthgamuwa Isini , Fenelon Jane C. , Roser Alice , Meer Haley , Johnston Stephen D. , Dungan Ashley M. 
Published: December 2023

AbstractIndigenous gut microbial communities (microbiota) play critical roles in health and may be especially important for the mother and fetus during pregnancy. Monotremes, such as the short‐beaked echidna, have evolved to lay and incubate an egg, which hatches in their pouch where the young feeds. Since both feces and eggs pass through the cloaca, the fecal microbiota of female echidnas provides an opportunity for vertical transmission of microbes to their offspring. Here, we characterize the gut/fecal microbiome of female short‐beaked echidnas and gain a better understanding of the changes that may occur in their microbiome as they go through pregnancy. Fecal samples from four female and five male echidnas were obtained from the Currumbin Wildlife Sanctuary in Queensland and sequenced to evaluate bacterial community structure. We identified 25 core bacteria, most of which were present in male and female samples. Genera such as Fusobacterium, Bacteroides, Escherichia‐Shigella, and Lactobacillus were consistently abundant, regardless of sex or gestation stage, accounting for 58.00% and 56.14% of reads in male and female samples, respectively. The echidna microbiome remained stable across the different gestation stages, though there was a significant difference in microbiota composition between male and female echidnas. This study is the first to describe the microbiome composition of short‐beaked echidnas across reproductive phases and allows the opportunity for this novel information to be used as a metric of health to aid in the detection of diseases triggered by microbiota dysbiosis.
Stevioside Ameliorates Prenatal Obesity Induced Postpartum Depression: The Potential Role of Gut Barrier Homeostasis
Authors: Ye Jin , Shi Renjie , Fan Hua , Wang Danna , Xiao Chunxia , Yang Tianyingzi , Ye Peng , Xia Bing , Zhao Beita , Wang Yutang , Liu Xuebo 
Published: December 2023

ScopePostpartum depression and cognitive impairment are the common complications of prenatal obesity. Stevioside is a non‐nutritive natural sweetener with antioxidant and anti‐inflammatory. However, its effects on depression behaviors and cognitive impairment induced by a high‐fat diet (HFD) remain unclear.Methods and resultsAn 8‐week HFD is used to establish a prenatal obesity model in female C57BL/6J mice to explore the improvement effects of stevioside (0.5 mg mL−1 in drinking water) on maternal depression and cognitive dysfunction after weaning. The results demonstrated that stevioside improves behavioral performance of obese maternal mice, and inhibits neuronal damage and 5‐hydroxytryptamine (5‐HT) abnormality induced by HFD. In addition, stevioside inhibits oxidative stress by reducing malondialdehyde (MDA) and increasing superoxide dismutase (SOD) and glutathione (GSH) activities in the brains of obese maternal mice. Additionally, stevioside improves gut barrier integrity and prevented lipopolysaccharide (LPS) extravasation, and alleviates neuroinflammation. Correlation analysis shows that gut barrier and serum LPS are closely related to behavioral performance and brain biochemical indicators.ConclusionStevioside is capable to prevent prenatal obesity‐induced cognitive and mood disorders by restoring intestinal barrier damage and inhibiting inflammation.