bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward reducing racialized pain care disparities: Approaching cannabis research and access through the lens of equity and inclusion
Authors: Worster Brooke , Meghani Salimah H. , Leader Amy E. , Nugent Shannon M. , Jones Katie Fitzgerald , Yeager Katherine A. , Liou Kevin , Ashare Rebecca L. 
Published: November 2023

AbstractThere is growing interest in cannabis use for cancer pain. This commentary aims to discuss the evidence surrounding cannabis use for cancer pain in the context of the long‐racialized landscape of cannabis policies and the disparity in pain control among cancer patients holding minoritized racial identities. Much evidence surrounding both the benefits and harms of cannabis use in cancer patients, and all patients in general, is lacking. Although drawing on the research in cancer that is available, it is also important to illustrate the broader context about how cannabis’ deep roots in medical, political, and social history impact patient use and health care policies. There are lessons we can learn from the racialized disparities in opioid risk mitigation strategies, so they are not replicated in the settings of cannabis for cancer symptom management. Additionally, the authors intentionally use the term “cannabis” here rather than “marijuana.: In the early 1900s, the lay press and government popularized the use of the word “marijuana” instead of the more common “cannabis” to tie the drug to anti‐Mexican prejudice.
Cloud forensics: A centralized cloud provenance investigation system usingMECC
Authors: Nasreen Shaiqa , Mir Ajaz Hussain 
Published: November 2023

SummaryAs a new development in digital forensics, cloud forensics (CF) is being utilized to combat cyber‐crimes. Nevertheless, the centralized compilation and preservation of evidence lessen the reliability of digital evidence. Also, the Cloud environment faces the challenge of securing the Provenance Information (PI) without being forged or tampered with, by either an internal or an external party. In the existing works, the researchers have made several attempts to trounce the issues of CF investigation but still, those issues have not been eliminated. Thus, by employing modified elliptic curve cryptography (MECC), an enhanced CF investigation system (CFIS) grounded on a centralized cloud provenance (CCP) system has been proposed to surpass such issues. For encrypting the data for a user and to securely upload and download the data, the MECC was proposed. For producing the group key, SHA‐512 was wielded. The proposed system's performance, when appraised, was found to exhibit enhanced performance against the prevailing methodologies.
The Biomimetic Synthesis of Polyarylated Fluorenes, Relevant to Selaginellaceae Polyphenols, Leading to the Spontaneous Formation of Stable Radicals
Authors: Nallappan Sundaravelu , Lapinskaite Ringaile , Hájíček Josef , Kunák Dominik , Čambal Peter , Nečas David , Císařová Ivana , Atalay Hazal Nazlıcan , Tumer Tugba B. , Tarábek Ján , Schwarzová‐Pecková Karolina , Rycek Lukas 
Published: November 2023

AbstractThis work reports a biomimetic synthesis of polyarylated fluorene derivatives. The molecules are formed via intramolecular electrophilic aromatic substitution, resembling a cyclization leading towards the natural selaginpulvilins from selaginellins. The scope of the reaction was investigated, and the products were obtained in 60–95 % yields. Some of the compounds decompose to a stable radical. We investigated the nature and the origin of the radical using experimental methods, including EPR or electrochemical measurements, as well as theoretical methods, such as DFT calculations. Based on our observations, we hypothesize, that phenoxy radicals are formed in the first instance, which however undergo internal rearrangement to thermodynamically more stable carbon‐centered radicals. The preliminary data also show the cytotoxic properties of some of the molecules.
Electrochemical Synthesis and Electrocatalytic Oxygen‐Evolution Performance of Two‐Dimensional NiCo‐BPDC Materials
Authors: Liu Mei‐Chen , Wei Jin‐Zhi , Xie Lu‐Hang , Jing Chang‐Yi , Yu Yue , Qiao Yu , Zhang Feng‐Ming 
Published: November 2023

AbstractMetal‐organic frameworks (MOFs) have been widely studied as electrocatalysts, and the research strategy to improve their electrocatalytic oxygen evolution reaction (OER) performance is to modify their structure. In this paper, two‐dimensional bimetallic MOFs were constructed to improve electrocatalytic OER performance. Using a mild electrochemical method with Ni and Co as metal sources and 4, 4 ′‐biphenyl dicarboxylic acid (H2BPDC) as ligand, two‐dimensional NiCo‐BPDC was synthesized and then deposited on a carbon cloth electrode. The results show that NiCo‐BPDC/CC possessed a low overpotential of 356 mV at a current density of 20 mA cm−2 with a small Tafel slope of 86 mV dec−1 in 1.0 M KOH solution. The two‐dimensional NiCo‐BPDC exhibits excellent electrocatalytic OER performance because the coordination of Ni and Co in the material and the interaction of the two‐dimensional materials provide a large electrochemically active surface area and expose more metal active sites for OER, thus improving the reaction efficiency and indicating NiCo‐BPDC as potential OER electrocatalyst.
ASIC implementation of ECG denoising FIR filter by using hybrid Vedic–Wallace tree multiplier
Authors: Janwadkar Sudhanshu , Dhavse Rasika 
Published: November 2023

AbstractThe design of hand‐held portable devices for cardiovascular health monitoring based on the analysis of electrocardiogram (ECG) is a hot topic of research nowadays. Digital filters, possibly designed using digital multipliers, are a critical module in the design of such analysis systems. This paper presents the ASIC design of a 64th‐order digital low‐pass FIR filter to be used in ECG denoising applications. The FIR filter is optimized for usage in battery‐operated portable systems, wherein power consumption and on‐chip area are crucial parameters of concern. These challenges are met by employing a novel multiplier architecture, which we design by hybridizing the two popular digital multiplication algorithms, namely, the Vedic multiplication algorithm and the Wallace tree multiplication algorithm. The proposed multiplier consumes lower area and power consumption than either of the aforementioned conventional multiplication algorithms. This is established through FPGA‐based implementations on Artix‐7 FPGA, for the various wordlengths. The area and power optimizations are further exercised by two proposed techniques, namely, elimination of redundant multipliers, and power gating using the proposed zero‐detector circuit. RTL‐to‐GDSII flow has been completed using Cadence digital design and sign‐off tools for SCL 180 nm technology. The results indicate that the proposed filter architecture occupies 16.38% lower area and 79.58% lower power consumption than the contemporary designs described in the literature.
Guidelines for establishing a cytometry laboratory
Authors: Belkina Anna C. , Roe Caroline E. , Tang Vera A. , Back Jessica B. , Bispo Claudia , Conway Alexis , Chakraborty Uttara , Daniels Kathleen T. , de la Cruz Gelo , Ferrer‐Font Laura , Filby Andrew , Gravano David M. , Gregory Michael D. , Hall Christopher , Kukat Christian , Mozes André , Ordoñez‐Rueda Diana , Orlowski‐Oliver Eva , Pesce Isabella , Porat Ziv , Poulton Nicole J. , Reifel Kristen M. , Rieger Aja M. , Sheridan Rachael T. C. , Van Isterdael Gert , Walker Rachael V. 
Published: November 2023

AbstractThe purpose of this document is to provide guidance for establishing and maintaining growth and development of flow cytometry shared resource laboratories. While the best practices offered in this manuscript are not intended to be universal or exhaustive, they do outline key goals that should be prioritized to achieve operational excellence and meet the needs of the scientific community. Additionally, this document provides information on available technologies and software relevant to shared resource laboratories. This manuscript builds on the work of Barsky et al. 2016 published in Cytometry Part A and incorporates recent advancements in cytometric technology. A flow cytometer is a specialized piece of technology that require special care and consideration in its housing and operations. As with any scientific equipment, a thorough evaluation of the location, space requirements, auxiliary resources, and support is crucial for successful operation. This comprehensive resource has been written by past and present members of the International Society for Advancement of Cytometry (ISAC) Shared Resource Laboratory (SRL) Emerging Leaders Program https://isac-net.org/general/custom.asp?page=SRL-Emerging-Leaders with extensive expertise in managing flow cytometry SRLs from around the world in different settings including academia and industry. It is intended to assist in establishing a new flow cytometry SRL, re‐purposing an existing space into such a facility, or adding a flow cytometer to an individual lab in academia or industry. This resource reviews the available cytometry technologies, the operational requirements, and best practices in SRL staffing and management.
Worldwide burden and trends of diabetes among people aged 70 years and older, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019
Authors: Jiang Shimin , Yu Tianyu , Di Dingxin , Wang Ying , Li Wenge 
Published: November 2023

AbstractBackgroundDiabetes places a significant burden on personal and public health. However, a comprehensive assessment of the burden of diabetes in older adults is lacking. We aimed to estimate the global burden of diabetes and explore trends for the population aged ≥70 from 1990 to 2019.MethodsUsing data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, the prevalence, mortality, and disability‐adjusted life‐years (DALYs) of diabetes among people aged ≥70 were estimated by sex and age group in 2019. We also assessed the epidemiological trend of diabetes from 1990 to 2019.ResultsIn 2019, 110.1 million (95% uncertainty interval [UI]: 101.2–119.4) people aged ≥70 years were living with diabetes (types 1 and 2 combined) with a global prevalence of 23.7% (21.8%–25.8%). Worldwide, 181.9 deaths (163.0–194.7) per 100,000 population and 4512.3 DALYs (3861.3–5264.2) per 100,000 population occurred due to diabetes. In 2019, minor sex‐related disparities in the burden of diabetes were identified among specific age and sex groups. From 1990 to 2019, the prevalence of diabetes increased by 39.7% (37.7%–41.7%), and the related mortality and DALY rates also increased (16.4% [9.43%–22.9%] and 22.3% [17.2%–27.0%], respectively).Conclusion and RelevanceThe global burden of diabetes in adults aged ≥70 has increased markedly from 1990 to 2019. As the population continues to age, there is an urgent need to combat the increasing disease burden.
Dried blood spots for erythropoietin analysis: Detection of micro‐doses, EPO c.577del variant and comparison with in‐competition matching urine samples
Authors: Heiland Carmel E. , Martin Laurent , Zhou Xinmiao , Zhang Lisi , Ericsson Magnus , Marchand Alexandre 
Published: November 2023

AbstractThe abuse of recombinant erythropoietin (rEPO) and other erythropoietin (EPO) receptor agonists (ERAs) in sports prompted the need for sensitive detection methods of these substances. Dried blood spot (DBS) samples offer an easy solution for simultaneous collection of blood and urine during a doping control, but sensitivity issues are often presented as a challenge for routine EPO analysis from DBS. Its potential use for detecting rEPO micro‐doses and the EPO gene c.577del variant thus needed further demonstration. Here, capillary blood collected from the arm skin of 111 athletes with Tasso‐M20 (17.5 μL/spot), collected during professional triathlon competitions, were analysed. Also, venous blood samples from healthy volunteers were used to prepare several spots of 20 μL on Mitra VAMS (from an rEPO micro‐dose study) and Whatman filter paper (from an EPO gene variant study). Immunopurification of 2 spots with MAIIA EPO Purification Gel Kit and analysis with sodium N‐lauroylsarcosinate polyacrylamide gel electrophoresis (SAR‐PAGE)/Western blot resulted in sensitive detection of (1) micro‐doses of rEPO from Mitra VAMS, (2) endogenous EPO from Tasso‐M20 in all in‐competition subjects, and (3) the EPO c.577del variant from Whatman filter paper. Additionally, in‐competition endogenous EPO was detected in DBS even when matching urine samples had undetectable EPO. In conclusion, this work demonstrated that DBS can be a useful complementary matrix to urine samples for EPO detection.
Emerging trends and hotspots in the links between the bile acids and NAFLD from 2002 to 2022: A bibliometric analysis
Authors: Shibo Cong , Sili Wang , Yanfang Qiao , Shuxiao Gu , Susu Liu , Xinlou Chai , Yongsheng Zhang 
Published: November 2023

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) is a metabolic syndrome of the liver, and its incidence is increasing worldwide. Accumulating evidence suggests that bile acids are associated with NAFLD. Although many studies on bile acids and NAFLD have been published over the past 20 years, the authors of this study have not found a relevant bibliometric analysis in this field. Therefore, this study aimed to evaluate the trend of publications, summarize current research hotspots and predict future research directions through bibliometric analysis in this field.MethodArticles related to bile acids and NAFLD published between 2002 and 2022 were obtained from the Science Citation Index‐Expanded of Web of Science Core Collection. Microsoft Excel, CiteSpace, VOSviewer and Bibliometric Online Analysis Platform were used to analyse the publication trends and research hotspots in this field.ResultsAmong the articles published between 2002 and 2022, we retrieved 1284 articles related to bile acids and NAFLD, and finally included 568 articles. The USA was dominant until 2020, after which China surpassed the USA to become the dominant force. These two countries cooperate the most closely, and are also the most active in international cooperation. The University of California (UCL) was the most published institution, with a total of 31 publications. There were six authors who have published nine articles and ranked first. The keywords cluster labels show the 10 main clusters: #0fatty liver, #1obeticholic acid, #2oxidative stress, #37 alpha hydroxy 4 cholesten 3 one, #4deoxycholic acid, #5nonalcoholic fatty liver disease, #6mouse model, #7fibroblast growth factor 21, #8animal models, #9high‐fat diet. Keywords burst analysis revealed a higher intensity of study for the nuclear receptor, FXR, and metabolic syndrome.ConclusionBile acids have become an important research direction in the field of NAFLD, and the intervention of gut microbiota in NAFLD by acting on bile acids may become a potential hotspot for future research. This study provides reference and guidance for future research, and will help scholars better explore the field and innovatively discover the mechanisms and treatments of NAFLD.
Cost–utility of cardiac contractility modulation in patients with heart failure with reduced ejection fraction in Italy
Authors: Narducci Maria Lucia , Nurchis Mario Cesare , Ballacci Federico , Giordano Federica , Calabrò Giovanna Elisa , Massetti Massimo , Crea Filippo , Aspromonte Nadia , Damiani Gianfranco 
Published: November 2023

AbstractAimsCardiac contractility modulation (CCM) is a device therapy for heart failure, based on the delivery of high‐voltage biphasic impulses to the right ventricular septum during the myocardial absolute refractory period. This study evaluated the cost‐effectiveness of CCM therapy plus optimal medical therapy (OMT) vs. OMT alone in patients with heart failure with reduced ejection fraction.Methods and resultsA Markov model with a lifespan time horizon was developed to assess the cost–utility using the FIX trials as main data sources. A deterministic sensitivity analysis and a probabilistic sensitivity analysis were run to analyse the decision uncertainty in the model through cost‐effectiveness acceptability curve (CEAC) and cost‐effectiveness acceptability frontier (CEAF). Value of information analysis was also conducted computing the expected value of perfect information (EVPI) and the expected value of partial perfect information. The base case results showed that the CCM plus OMT option was highly cost‐effective compared with OMT alone with an incremental cost–utility ratio of €7034/quality‐adjusted life year (QALY). The CEAC and CEAF illustrated that for all willingness to pay levels above €5600/QALY, tested up to €50 000/QALY, CCM plus OMT alternative had the highest probability of being cost‐effective. The EVPI per patient was estimated to be €124 412 on a willingness to pay threshold of €30 000/QALY.ConclusionsFor patients with heart failure with reduced ejection fraction, CCM therapy could be cost‐effective when taking a lifetime horizon. Further long‐term, post‐approval clinical studies are needed to verify these results in a real‐world context, particularly concerning the effect of CCM therapy on mortality.
Photoinduced Single‐Electron Reduction of Alkenes.
Authors: Li Xiang , Tu Yong‐Liang , Chen Xiang‐Yu 
Published: November 2023

AbstractAlkenes serve as versatile building blocks in organic synthesis. However, the challenge of achieving single‐electron reduction of alkenes persists. In recent years, photocatalysis has emerged as a promising and efficient tool for accomplishing the single‐electron reduction of alkenes. Given the potential benefits that can be derived from photoinduced single‐electron reduction of alkenes, including the development of potent catalytic systems to enable diverse alkene difunctionalization reactions, it is necessary to provide a conceptual understanding of this emerging field. Hence, we present an overview of current synthetic techniques for photoinduced single‐electron reduction of alkenes.
Research on serial lithium‐ion battery alternating discharge equalization control systems
Authors: Zhang Chuanwei , Sun Weixin , Huang Jing , Xia Zhan , Li Chenxi , Xu Xusheng 
Published: November 2023

AbstractTo improve the discharge equalization efficiency of the battery and prevent the occurrence of overdischarge, in this paper, the 18,650 ternary lithium battery is taken as the object of investigation, and an alternating equalization control system for the discharge process of serial cells is proposed. The system implements the alternating discharge of serial cells by switching on and off, using state of charge (SOC) as the equalization variable, and eventually completes the equalization control of the entire battery pack. Discharge simulations were performed in Matlab/Simulink for faulty and normal operating conditions of the battery pack, respectively. The findings indicate that even in the presence of a malfunction, the battery pack can continue to operate continuously for a while; in contrast, under ideal circumstances, the battery pack is capable of maintaining SOC balance throughout the discharge process. Eventually, five batteries are used to construct the experimental platform for the alternating equalization system. The battery pack can still perform selective discharge under fault conditions until the battery pack reaches the discharge cutoff condition. Under normal conditions, the maximum SOC difference of all five batteries can stabilize at about 1%. The experimental results show that the proposed equalization control system can achieve the equalization of battery discharge and prolong the discharge time, and can prevent the occurrence of battery over discharge.
A probably secure biometric‐based authentication and key agreement scheme for Internet of Drones
Authors: Gautam Deepika , Rana Aryan , Obaidat Mohammad S. , Kumar Pankaj , Prajapat Sunil 
Published: November 2023

AbstractThe Internet of Drones (IoD) is one of the world's most recent and innovative technology. Drones are most prominent IoT (Internet of Things) gadgets and their applications span from commercial to domestic. The sensitive data stored in drones has increased the demand for the security of communication in the IoD. As a result, numerous authentication and key agreement techniques have been developed to proffers secure communication among the entities of the IoD network. However, after scrutinizing the security of these protocols, many IoD protocols were observed to be susceptible to different cryptographic attacks. This has enhanced the necessity for an improved and efficient authentication scheme in IoD. In this article, we first investigate Zhang et al.'s approach and demonstrate that although it offers security verification, it has certain design problems. It is, furthermore, shown to be vulnerable to privileged insider, offline password guessing, and stolen smart device attacks. Second, we propose a novel biometric‐based scheme that includes countermeasures to protect against these flaws. The security of the mechanism is examined under real or random oracle model, informal security analysis and scyther simulation for numerous cryptographic assaults. Also, the performance analysis substantiates the competency of the proposed scheme corresponding to computation and communication cost with existing schemes.
Durable superhydrophobic surface in wearable sensors: From nature to application
Authors: Dai Ziyi , Lei Ming , Ding Sen , Zhou Qian , Ji Bing , Wang Mingrui , Zhou Bingpu 
Published: November 2023

AbstractThe current generation of wearable sensors often experiences signal interference and external corrosion, leading to device degradation and failure. To address these challenges, the biomimetic superhydrophobic approach has been developed, which offers self‐cleaning, low adhesion, corrosion resistance, anti‐interference, and other properties. Such surfaces possess hierarchical nanostructures and low surface energy, resulting in a smaller contact area with the skin or external environment. Liquid droplets can even become suspended outside the flexible electronics, reducing the risk of pollution and signal interference, which contributes to the long‐term stability of the device in complex environments. Additionally, the coupling of superhydrophobic surfaces and flexible electronics can potentially enhance the device performance due to their large specific surface area and low surface energy. However, the fragility of layered textures in various scenarios and the lack of standardized evaluation and testing methods limit the industrial production of superhydrophobic wearable sensors. This review provides an overview of recent research on superhydrophobic flexible wearable sensors, including the fabrication methodology, evaluation, and specific application targets. The processing, performance, and characteristics of superhydrophobic surfaces are discussed, as well as the working mechanisms and potential challenges of superhydrophobic flexible electronics. Moreover, evaluation strategies for application‐oriented superhydrophobic surfaces are presented.