bluuebunny/crossref_metadata_2025_split huggingface dataset:
Juego sensoperceptivo: estrategia didáctica – pedagógica orientada al desarrollo del equilibrio, las habilidades motrices, intelectuales y el aprendizaje en estudiantes de básica elemental (Sub-nivel 2)
Authors: Velastegui López Luis Efraín , Solís López Daniela Elizabeth , Gavilanes Cordones Verónica Fernanda , Portero Aponte Jacqueline Alejandra 
Published: February 2024

Introducción: El Ministerio de Educación mediante el currículo incluye actualizaciones curriculares, para garantizar el desarrollo integral del niño, comprometiendo a los educadores en el proceso de enseñanza aprendizaje a través de juegos sensoperceptivos, estrategias, y métodos que potencien el equilibrio y el movimiento, considerando que se debe mejorar la movilidad, las capacidades manuales y habilidades motoras. Objetivo: determinar la importancia del juego sensoperceptivo: estrategia didáctica – pedagógica orientada al desarrollo del equilibrio, las habilidades motrices, intelectuales y el aprendizaje en estudiantes de Básica Elemental (Sub-nivel 2) en la Escuela de Educación General Básica Manuela Espejo. Metodología: adquiere un enfoque cualitativo, con un diseño no experimental, junto con el alcance descriptivo. La técnica aplicada fue la observación el instrumento fue validado mediante el programa estadístico SPSS para una mejor veracidad en el momento de efectuar la recolección de datos numéricos. Resultados: se estableció que la aplicación de juegos sensoperceptivos en Básica Elemental (Sub-nivel 2) es poco utilizada por las educadoras a pesar de sus ventajas, factor que afecta a la postura del cuerpo, el desarrollo del equilibrio, las habilidades motrices, intelectuales y el aprendizaje. Conclusión: Se diagnosticó las dificultades en el desarrollo del equilibrio, las habilidades motrices, intelectuales y el aprendizaje en estudiantes de Básica Elemental (Sub-nivel 2) en la Escuela de Educación General Básica Manuela Espejo. Por tanto, se establece que en el sistema formativo la implementación de estrategias y actividades lúdicas permitirán lograr mejores resultados en el rendimiento académico, la toma de decisiones, solución de problemas y trabajo en equipo. Área de estudio general: Didáctica. Área de estudio específica: estrategias lúdicas.
Comorbilidad del sobrepeso y la obesidad en perros y gatos
Authors: Cabascango Martínez Lucía Vanessa 
Published: February 2024

El sobrepeso y la obesidad son las enfermedades nutricionales más comunes en perros y gatos. La gran diferencia entre el sobrepeso en mascotas y humanos es que los animales no tienen la facultad de controlar su peso. Dependen única y exclusivamente de lo que les sirva su dueño. A partir del año edad es fundamental proporcionarles la dieta recomendada para su edad, especie y raza. De lo contrario, les llevaremos al sobrepeso, y de ahí a la obesidad. La obesidad se define como un exceso de grasa corporal suficiente como para producir enfermedad. Cuando el animal consume más calorías que las que gasta, la grasa se acumula en el cuerpo. En perros, el sobrepeso comienza cuando el animal sobrepasa entre un 15 y un 30% el peso establecido como normal para la raza. A partir de un 30%, estaríamos hablando de obesidad. En el caso de los gatos se considera que presentan sobrepeso cuando superan en más del 10% su “peso ideal”, y son obesos cuando lo supera en un 20%. La salud y la longevidad se ven afectados por los depósitos excesivos de grasa en el cuerpo. Las enfermedades asociadas con la obesidad y el sobrepeso, incluyen desordenes ortopédicos traumáticos o degenerativos, enfermedad cardiovascular que se manifiesta con insuficiencia cardiaca congestiva, intolerancia al ejercicio y al calor, predisposición a la diabetes mellitus, hipertensión, hiperlipidemias, carcinoma de células transicionales en vejiga y compromiso de la función inmune. Por otra parte, la obesidad y el sobrepeso aumentan el riesgo de sufrir tumores mamarios, y esto relacionado no solo con la obesidad sino con el consumo de comida casera y de carnes roja. Con esta revisión bibliográfica de literatura se busca reunir y resumir información científica, actualizada y específica acerca de las patologías que se asocian a la obesidad y el sobrepeso en perros y gatos, con la finalidad de comprender la fisiología de la patología y como el profesional Médico Veterinario puede intervenir oportunamente para controlar estos trastornos asociados a la nutrición de las mascotas.
SPORTS DENTISTRY: A REVIEW
Authors: Malhotra Taniya , Sachdeva Akshat , Bhateja Sumit , Arora Geetika 
Published: February 2024

Sports dentistry is one of the most important and upcoming fields in dentistry. Sports dentistry includes the prevention and management of athletics-related orofacial injuries and associated oral cavity diseases. The most noteworthy angle in forestalling sports-related orofacial injuries is guarding up with defensive devices, for example, appropriately fitting helmets, face masks and additionally mouth guards. Athletes are not well versed of the health implications of a traumatic injury to the mouth or of the potential for incurring severe head and orofacial injuries while playing.The dentist can play an essential role in notifying athletes, coaches and patients about the importance of preventing orofacial injuries in sports. The present article aims to elevate professional awareness and interest towards sports dentistry and the injuries.

Keywords: Dental injury, Sports dentistry, Mouth guard, Orofacial injuries.
Enhancing biomechanical machine learning with limited data: generating realistic synthetic posture data using generative artificial intelligence
Authors: Dindorf Carlo , Dully Jonas , Konradi Jürgen , Wolf Claudia , Becker Stephan , Simon Steven , Huthwelker Janine , Werthmann Frederike , Kniepert Johanna , Drees Philipp , Betz Ulrich , Fröhlich Michael 
Published: February 2024

Objective: Biomechanical Machine Learning (ML) models, particularly deep-learning models, demonstrate the best performance when trained using extensive datasets. However, biomechanical data are frequently limited due to diverse challenges. Effective methods for augmenting data in developing ML models, specifically in the human posture domain, are scarce. Therefore, this study explored the feasibility of leveraging generative artificial intelligence (AI) to produce realistic synthetic posture data by utilizing three-dimensional posture data.Methods: Data were collected from 338 subjects through surface topography. A Variational Autoencoder (VAE) architecture was employed to generate and evaluate synthetic posture data, examining its distinguishability from real data by domain experts, ML classifiers, and Statistical Parametric Mapping (SPM). The benefits of incorporating augmented posture data into the learning process were exemplified by a deep autoencoder (AE) for automated feature representation.Results: Our findings highlight the challenge of differentiating synthetic data from real data for both experts and ML classifiers, underscoring the quality of synthetic data. This observation was also confirmed by SPM. By integrating synthetic data into AE training, the reconstruction error can be reduced compared to using only real data samples. Moreover, this study demonstrates the potential for reduced latent dimensions, while maintaining a reconstruction accuracy comparable to AEs trained exclusively on real data samples.Conclusion: This study emphasizes the prospects of harnessing generative AI to enhance ML tasks in the biomechanics domain.
G-CSF increases calprotectin expression, liver damage and neuroinflammation in a murine model of alcohol-induced ACLF
Authors: Ortega-Ribera Martí , Zhuang Yuan , Brezani Veronika , Thevkar Nagesh Prashanth , Joshi Radhika S. , Babuta Mrigya , Wang Yanbo , Szabo Gyongyi 
Published: February 2024

Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induced murine model of ACLF.Methods: ACLF was triggered by a single alcohol binge (5 g/kg) in a bile duct ligation (BDL) liver fibrosis model. A subgroup of mice received two G-CSF (200 μg/kg) or vehicle injections prior to acute decompensation with alcohol. Liver, blood and brain tissues were assessed.Results: Alcohol binge administered to BDL-fibrotic mice resulted in features of ACLF indicated by a significant increase in liver damage and systemic inflammation compared to BDL alone. G-CSF treatment in ACLF mice induced an increase in liver regeneration and neutrophil infiltration in the liver compared to vehicle-treated ACLF mice. Moreover, liver-infiltrating neutrophils in G-CSF-treated mice exhibited an activated phenotype indicated by increased expression of CXC motif chemokine receptor 2, leukotriene B4 receptor 1, and calprotectin. In the liver, G-CSF triggered increased oxidative stress, type I interferon response, extracellular matrix remodeling and inflammasome activation. Circulating IL-1β was also increased after G-CSF treatment. In the cerebellum, G-CSF increased neutrophil infiltration and S100a8/9 expression, induced microglia proliferation and reactive astrocytes, which was accompanied by oxidative stress, and inflammasome activation compared to vehicle-treated ACLF mice.Conclusion: In our novel ACLF model triggered by alcohol binge that mimics ACLF pathophysiology, neutrophil infiltration and S100a8/9 expression in the liver and brain indicate increased tissue damage, accompanied by oxidative stress and inflammasome activation after G-CSF treatment.
Model of adoption of virtual tools by university students in the context of an emerging economy
Authors: López-Sánchez Jerri Alejandro , Patiño-Vanegas Juan Camilo , Valencia-Arias Alejandro , Rojas Coronel Angel Marcelo 
Published: February 2024

IntroductionThe impact of COVID-19 on higher education has necessitated a reevaluation of teaching methodologies, student engagement, and the integration of information and communication technologies (ICT) as pedagogical tools. This shift creates opportunities for innovation and collaborative learning environments among students.MethodsThis study aims to investigate the adoption of virtual tools by university students in Medellín. A sample of 373 students was surveyed using a quantitative approach with a descriptive scope. Factor analysis techniques were employed utilizing SPSS software to assess the associative relationships among variables and hypotheses within the framework of the Technology Acceptance Model (TAM).ResultsThe analysis revealed significant correlations, particularly between perceived ease of use and perceived usefulness. Notably, technological devices such as laptops and smartphones were identified as valuable tools for educational purposes, contributing to a positive attitude towards their utilization among students.DiscussionThe findings underscore the importance of students’ perceptions in shaping their attitudes towards ICT tools for teaching and learning. Understanding these perceptions is crucial for designing effective pedagogical strategies, particularly in crisis situations such as the COVID-19 pandemic, where virtual tools play a vital role in maintaining educational continuity. This study contributes to the ongoing discourse on the integration of virtual tools in higher education, highlighting avenues for further research and practical implications for educators and policymakers.
A comparison of the performance of 68Ga-Pentixafor PET/CT versus adrenal vein sampling for subtype diagnosis in primary aldosteronism
Authors: Yin Xuan , Ai Kai , Luo Jianguang , Liu Wei , Ma Xiaowei , Zhou Lianbo , Xiang Xin , Su Xin , Wang Yunhua , Li Yuan 
Published: February 2024

ObjectiveTo investigate the diagnostic efficiency and prognostic value of 68Ga-Pentixafor PET/CT in comparison with adrenal vein sampling (AVS) for functional lateralization in primary aldosteronism (PA). Histology and long-term clinical follow-up normally serve as the gold standard for such diagnosis.MethodsWe prospectively recruited 26 patients diagnosed with PA. All patients underwent 68Ga-Pentixafor PET/CT and AVS. Postsurgical biochemical and clinical outcomes of patients with unilateral primary aldosteronism (UPA), as diagnosed by PET/CT or AVS, were assessed by applying standardized Primary Aldosteronism Surgical Outcome (PASO) criteria. Immunohistochemistry (IHC) was performed to detect the expression of aldosterone synthase (CYP11B2) and CXCR4.ResultsOn total, 19 patients were diagnosed with UPA; of these, 13 patients were lateralized by both PET/CT and AVS, four patients were lateralized by PET-only, and two by AVS-only. Seven subjects with no lateralization on AVS and PET received medical therapy. All patients achieved complete biochemical success except one with nodular hyperplasia lateralized by AVS alone. The consistency between PET/CT and AVS outcomes was 77% (20/26). Moreover, CYP11B2-positive nodules were all CXCR4-positive and showed positive findings on PET. Patients who achieved complete biochemical and clinical success had a higher uptake on PET as well as stronger expression levels of CXCR4 and CYP11B2.ConclusionOur analysis showed that 68Ga-Pentixafor PET/CT could enable non-invasive diagnosis in most patients with PA and identify additional cases of unilateral and surgically curable PA which could not be classified by AVS. 68Ga-Pentixafor PET/CT should be considered as a first-line test for the future classification of PA.
The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis
Authors: Zhao Xiaofang , Yao Tianci , Song Bei , Fan Haohui , Liu Ting , Gao Guangyu , Wang Kun , Lu Weilin , Liu Chengyun 
Published: February 2024

BackgroundBody mass index (BMI) and fasting plasma glucose (FPG) are known risk factors for type 2 diabetes mellitus (T2DM), but data on the prospective association of the combination of BMI and FPG with T2DM are limited. This study sought to characterize the association of the combination of BMI and FPG (ByG) with T2DM.MethodsThe current study used the NAGALA database. We categorized participants by tertiles of ByG. The association of ByG with T2DM was expressed with hazard ratios (HRs) with 95% confidence intervals (CIs) after adjustment for potential risk factors.ResultsDuring a median follow-up of 6.19 years in the normoglycemia cohort and 5.58 years in the prediabetes cohort, the incidence of T2DM was 0.75% and 7.79%, respectively. Following multivariable adjustments, there were stepwise increases in T2DM with increasing tertiles of ByG. After a similar multivariable adjustment, the risk of T2DM was 2.57 (95% CI 2.26 - 2.92), 1.97 (95% CI 1.53 - 2.54) and 1.50 (95% CI 1.30 - 1.74) for a per-SD change in ByG in all populations, the normoglycemia cohort and the prediabetes cohort, respectively.ConclusionByG was associated with an increased risk of T2DM in Japan. The result reinforced the importance of the combination of BMI and FPG in assessing T2DM risk.
Circulating miRNAs as biomarkers for the diagnosis in patients with melanoma: systematic review and meta-analysis
Authors: Jones Nicholas , Nonaka Taichiro 
Published: February 2024

Objective: Melanoma is the most aggressive and deadly form of skin cancer, especially at later stages. There is currently no excellent diagnostic test established for the diagnosis of melanoma; however, circulating microRNAs (miRNAs) have shown some promise. We seek to conduct a systematic review and meta-analysis to establish the clinical utility of circulating miRNAs in diagnosing melanoma.Methods: PubMed, Wiley, and Web of Science were searched for studies that determined miRNA sensitivity and specificity in patients with melanoma. The included studies were assessed in Stata, and the sensitivity, specificity, summary receiver operating characteristic (SROC), positive likelihood ratio, negative likelihood ratio, and the area under the SROC curve (AUC) were calculated.Results: 9 studies with 898 melanoma patients were included in the meta-analysis. The circulating miRNAs showed high diagnostic accuracy with a sensitivity of 0.89 (p &lt; 0.001), specificity of 0.85 (p &lt; 0.001), diagnostic odds ratio of 45, and an area under the curve of 0.93.Conclusion: Circulating miRNAs have shown a high diagnostic power in detecting melanoma.
Identification of platelet-related subtypes and diagnostic markers in pediatric Crohn’s disease based on WGCNA and machine learning
Authors: Tang Dadong , Huang Yingtao , Che Yuhui , Yang Chengjun , Pu Baoping , Liu Shiru , Li Hongyan 
Published: February 2024

BackgroundThe incidence of pediatric Crohn’s disease (PCD) is increasing worldwide every year. The challenges in early diagnosis and treatment of PCD persist due to its inherent heterogeneity. This study’s objective was to discover novel diagnostic markers and molecular subtypes aimed at enhancing the prognosis for patients suffering from PCD.MethodsCandidate genes were obtained from the GSE117993 dataset and the GSE93624 dataset by weighted gene co-expression network analysis (WGCNA) and differential analysis, followed by intersection with platelet-related genes. Based on this, diagnostic markers were screened by five machine learning algorithms. We constructed predictive models and molecular subtypes based on key markers. The models were evaluated using the GSE101794 dataset as the validation set, combined with receiver operating characteristic curves, decision curve analysis, clinical impact curves, and calibration curves. In addition, we performed pathway enrichment analysis and immune infiltration analysis for different molecular subtypes to assess their differences.ResultsThrough WGCNA and differential analysis, we successfully identified 44 candidate genes. Following this, employing five machine learning algorithms, we ultimately narrowed it down to five pivotal markers: GNA15, PIK3R3, PLEK, SERPINE1, and STAT1. Using these five key markers as a foundation, we developed a nomogram exhibiting exceptional performance. Furthermore, we distinguished two platelet-related subtypes of PCD through consensus clustering analysis. Subsequent analyses involving pathway enrichment and immune infiltration unveiled notable disparities in gene expression patterns, enrichment pathways, and immune infiltration landscapes between these subtypes.ConclusionIn this study, we have successfully identified five promising diagnostic markers and developed a robust nomogram with high predictive efficacy. Furthermore, the recognition of distinct PCD subtypes enhances our comprehension of potential pathogenic mechanisms and paves the way for future prospects in early diagnosis and personalized treatment.
Exploring candidate biomarkers for rheumatoid arthritis through cardiovascular and cardiometabolic serum proteome profiling
Authors: Cuesta-López Laura , Escudero-Contreras Alejandro , Hanaee Yas , Pérez-Sánchez Carlos , Ruiz-Ponce Miriam , Martínez-Moreno Julio Manuel , Pérez-Pampin Eva , González Antonio , Plasencia-Rodriguez Chamaida , Martínez-Feito Ana , Balsa Alejandro , López-Medina Clementina , Ladehesa-Pineda Lourdes , Rojas-Giménez Marta , Ortega-Castro Rafaela , Calvo-Gutiérrez Jerusalem , López-Pedrera Chary , Collantes-Estévez Eduardo , Arias-de la Rosa Iván , Barbarroja Nuria 
Published: February 2024

IntroductionRA patients are at higher risk of cardiovascular disease, influenced by therapies. Studying their cardiovascular and cardiometabolic proteome can unveil biomarkers and insights into related biological pathways.MethodsThis study included two cohorts of RA patients: newly diagnosed individuals (n=25) and those with established RA (disease duration &gt;25 years, n=25). Both cohorts were age and sex-matched with a control group (n=25). Additionally, a longitudinal investigation was conducted on a cohort of 25 RA patients treated with methotrexate and another cohort of 25 RA patients treated with tofacitinib for 6 months. Clinical and analytical variables were recorded, and serum profiling of 184 proteins was performed using the Olink technology platform. ResultsRA patients exhibited elevated levels of 75 proteins that might be associated with cardiovascular disease. In addition, 24 proteins were increased in RA patients with established disease. Twenty proteins were commonly altered in both cohorts of RA patients. Among these, elevated levels of CTSL1, SORT1, SAA4, TNFRSF10A, ST6GAL1 and CCL18 discriminated RA patients and HDs with high specificity and sensitivity. Methotrexate treatment significantly reduced the levels of 13 proteins, while tofacitinib therapy modulated the expression of 10 proteins. These reductions were associated with a decrease in DAS28. Baseline levels of SAA4 and high levels of BNP were associated to the non-response to methotrexate. Changes in IL6 levels were specifically linked to the response to methotrexate. Regarding tofacitinib, differences in baseline levels of LOX1 and CNDP1 were noted between non-responder and responder RA patients. In addition, response to tofacitinib correlated with changes in SAA4 and TIMD4 levels. ConclusionIn summary, this study pinpoints molecular changes linked to cardiovascular disease in RA and proposes candidate protein biomarkers for distinguishing RA patients from healthy individuals. It also highlights how methotrexate and tofacitinib impact these proteins, with distinct alterations corresponding to each drug’s response, identifying potential candidates, as SAA4, for the response to these therapies.
DNA metabarcoding reveals a diverse, omnivorous diet of Arctic amphipods during the polar night, with jellyfish and fish as major prey
Authors: Dischereit Annkathrin , Beermann Jan , Lebreton Benoit , Wangensteen Owen S. , Neuhaus Stefan , Havermans Charlotte 
Published: February 2024

IntroductionCurrently, Arctic marine ecosystems are witnessing the most rapid physical changes worldwide, leading to shifts in pelagic and benthic communities and food web structure, concomitant with the introduction of boreal species. Gelatinous zooplankton or jellyfish represent one particular group of which several boreal species are prone to undergo significant poleward range expansions and population increases in the Arctic in the course of the ongoing changes. Historically, jellyfish were considered a trophic dead-end, but an increasing number of studies using modern tools have highlighted their role as major prey items in marine food webs. In this study, we aimed to verify the role of jellyfish and other metazoans as food sources in the Arctic polar night food web, when pelagic resources are limited.MethodsWe identified the diet of different bentho-pelagic amphipod species in the Atlantifying Kongsfjorden (West Svalbard) during the polar night. We regularly sampled lysianassoid and gammarid amphipods using baited traps and hand nets over a period of one month during the polar night and identified their diet spectrum by applying DNA metabarcoding (COI) to their stomach contents.ResultsWe demonstrate that all investigated species are omnivorous. Fish species including polar cod and snailfish, likely in the shape of carrion, played an important role in the diet of the scavengers Orchomenella minuta and Anonyx sarsi. Predation and potential scavenging on jellyfish contributed to the diet of all four investigated species, particularly for the species Gammarus setosus and G. oceanicus, as evidenced by high read abundances and high frequencies of occurrence. Besides jellyfish, crustaceans and macroalgae were important components of the diet of the two Gammarus species.DiscussionThe diverse jellyfish community present in Kongsfjorden in the polar night is clearly being utilized as a food source, either through pelagic feeding or feeding on jelly-falls, albeit to a different extent in the local amphipod community. These findings provide novel insights into the Arctic food web during the polar night and represent the first evidence of feeding on natural (non-experimental) jelly-falls.