bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redefining the “shape” of things to come – a case study on marketing a taboo product and averting a potential crisis
Authors: Anam Rumana Liza 
Published: December 2023

Research methodology
The case is based on interviews in 2022 with the founder of Shape, Monoshita Ayruani, supplemented by classroom testing and secondary sources such as textbooks, journals, newspapers and other pertinent sources such as reports produced by marketing and consulting firms.

Case overview/synopsis
Shape is a private limited company operating in Bangladesh, a country in South Asia. Bangladesh is a fast-developing country where the people (the vast majority of whom are young) are practical and forward thinking, conservative, yet also generally tolerant. Its CEO is Monoshita Ayruani, who has had several years of experience in a PR and Marketing agency before starting Shape. It produces and sells “innerwear” or undergarments, which are their staple products, as well as clothing, bath products, sleepwear and various other products targeted at women. Starting off as an online business in 2019, it was about to find its footing in the market when the COVID-19 pandemic hit. The problem faced by Shape at the beginning was that digital marketing was not resulting in word of mouth for the product, as undergarments were considered too “taboo” to talk or share about with most people. The second problem faced was the sudden protests about Westernised clothing and culture in 2022, which may potentially threaten the company.

Complexity academic level
This case would be well suited for an undergraduate or graduate-level Marketing or Strategic Management course that exposes students to the challenges of promoting a new brand and marketing taboo products imported from abroad, in a largely conservative and culturally sensitive market, and preventing a potential crisis when protests break out. The case also touches on international supply chain problems, so may also be taught in an International Business course. The level of difficulty is intermediate as the problems are nuanced.
Decrease in climatic disequilibrium associated with climate change and species abundance shifts in Mediterranean plant communities
Authors: Pérez‐Navarro María Angeles , Lloret Francisco , Ogaya Romà , Estiarte Marc , Peñuelas Josep 
Published: December 2023

Abstract

Climate change induces changes in plant communities according to species' climatic requirements. These changes can be assessed by community climatic disequilibrium (CD), which corresponds to the difference between the climate inferred from the climatic requirements of the species in a community (community‐inferred climate, CIC) and the local observed climate.

We assessed changes in CIC and CD during a long‐term climatic manipulation (warming and drought treatments), embedded within the ongoing trends of climate change, in a Mediterranean shrubland (NE Iberian Peninsula) during 1999–2014. We used plant censuses, species distribution and climate layers since 1979 to create a multivariate environmental space where CIC and CD trends were estimated for 1999–2014.

CD consistently decreased, concomitant with an overall climate change‐derived increase in aridity (higher temperature and lower precipitation). CIC significantly changed during 1999–2014, reflecting the reshuffling of the community composition due to an increase in the abundance of species distributed in warmer, drier and more seasonal localities. Overall, treatments simulating greater climate change did not accelerate the decrease in CD. However, a trend of steeper diminution of CD was observed under warming treatment. In turn, under drought treatment the species less adapted to seasonality and aridity became less abundant. This community tracking of climate did not follow yearly climatic variability; instead, it was detected by the CD trend at the decadal scale.

Synthesis. The procedure developed to measure CD reflects demographic behaviours, thus providing a reliable method to assess the impact of climate change on species and communities. The study demonstrates the current, rapid tracking of Mediterranean woody plant communities to climate change. This tracking results from changes in the abundance of species according to their climatic requirements, inferred from their distribution. However, inertia in demographic processes implies that plant communities do not immediately fit current climate change at local level, as supported by the minor effect of experimentally accentuated climate change.
Effects of a digital cognitive behavioral therapy for insomnia on sleep and alcohol consumption in heavy drinkers: A randomized pilot study
Authors: Verlinden Justin J. , Moloney Mairead E. , Vsevolozhskaya Olga A. , Ritterband Lee M. , Winkel Fiona , Weafer Jessica 
Published: December 2023

AbstractBackgroundInsomnia is a well‐established, prospective risk factor for Alcohol Use Disorder. Thus, targeting sleep problems could serve as a novel and efficacious means of reducing problematic drinking. Here, we examined the potential utility of a well‐validated, interactive, easy to use, self‐paced digital cognitive behavioral therapy for insomnia program. In a randomized, single‐blind pilot study, we examined the impact of treatment with Sleep Healthy Using the Internet (SHUTi) on drinking and sleep outcomes in a sample of heavy drinkers with insomnia.MethodsHeavy drinking men (n = 28) and women (n = 42) with insomnia were randomly assigned to complete either the SHUTi program or a control patient education program. Subjective measures of sleep and alcohol use were administered at baseline, immediately following completion of the intervention, 3 months post‐intervention, and 6 months post‐intervention. Sleep outcomes were assessed using the Insomnia Severity Index and Pittsburgh Sleep Quality Index. Drinking outcomes were assessed using the 30‐Day Timeline Follow‐Back calendar. We used linear mixed effects models to compare groups on both insomnia and drinking outcomes.ResultsData from all 70 subjects (SHUTI: n = 40; control: n = 30) were analyzed. Linear mixed effects models showed that SHUTi significantly reduced insomnia symptoms (p = 0.01) and drinking outcomes (ps < 0.05) more than the control condition over time. Trend‐level effects on sleep quality (p = 0.06) were also observed. No adverse events were reported.ConclusionsImproving sleep may be an effective treatment intervention for reducing hazardous drinking in at‐risk individuals. Further, findings provide preliminary support for the implementation of an easily accessible health behavior intervention with significant public health impact in a high‐risk population.
Mindfulness‐based interventions for body image dissatisfaction among clinical population: A systematic review and meta‐analysis
Authors: Gopan Hrishi , Rajkumar Eslavath , Gopi Aswathy , Romate John 
Published: December 2023

AbstractPurposeMindfulness‐based interventions (MBIs) are well‐validated interventions to enhance the favourable body image of individuals. Despite their wide application, the efficacy of MBIs in reducing body image dissatisfaction (BID) among various clinical populations remains unclear. This study aims to expand the literature on MBIs for BID and identify effective types of MBIs for reducing BID in diverse clinical populations for future research and practice.MethodsA systematic search for studies published in English on the effectiveness of MBIs for BID among the clinical population was done on APA PsycNet, PubMed, Science Direct, Web of Science and Google Scholar databases in August 2023. Of the 1962 articles initially identified, 17 were found eligible and evaluated based on the JBI checklist.ResultsRandom effects meta‐analyses on six MBIs revealed their effectiveness in reducing BID among the clinical population (SMD = −.59 and 95% CI = −1.03 to −.15, p = .009), with Acceptance and Commitment Therapy (ACT) (SMD = −1.29, 95% CI = −2.06 to −.52, p = .001) and My Changed Body (MyCB) (SMD = −.24, 95% CI = −.46 to −.01, p = .04) reporting significant effect sizes. Among the patients with breast cancer, MyCB (SMD = −.24, 95% CI = −.46 to −.01, p = .04) showed a significant effect size.ConclusionsMBIs appear to be promising interventions in reducing BID among the clinical population. However, findings should be considered cautiously due to the possible publication bias, high heterogeneity and fewer available studies.
Is conservative opposition to climate change threat‐based? Articulating an integrated threat model of climate change attitudes
Authors: Stanley Samantha K. , Jylhä Kirsti M. , Leviston Zoe , Walker Iain 
Published: December 2023

AbstractThroughout the literature, there are assertions that those endorsing conservative ideologies reject the science and solutions of climate change due to perceived threat. That is, they fear that accepting climate change means accepting problems with a favoured socioeconomic system and supporting action on climate change threatens to disrupt these systems. We draw together lines of research and reasoning on this topic to outline three key predictions this perspective makes about the drivers of conservative denial of climate change and opposition to climate policy. The first is that an asymmetry exists in climate‐related threat perceptions, whereby greater endorsement of conservative ideology predicts lower perceived threat from climate change and greater perceived threat from climate reform. Second, climate‐related threat perceptions are multifaceted, such that threats to economic and cultural well‐being can be experienced, at personal or collective levels. Third, the asymmetry in threat perceptions explains conservatives' lower support for pro‐climate reforms. We then specify a new integrated threat model of climate change attitudes, review the current evidence for and against each prediction in this model and outline ways to interrogate these theoretical predictions with empirical research. Doing so will advance understanding of the underpinnings of ideological disagreement on climate change.
Short‐term psychosocial outcomes of adding a non‐contrast abdominal computed tomography (CT) scan to the thoracic CT within lung cancer screening
Authors: Usher‐Smith Juliet A. , Godoy Angela , Kitt Jessica , Farquhar Fiona , Waller Jo , Sharp Stephen J. , Shinkins Bethany , Cartledge Jon , Kimuli Michael , Burge Sarah W. , Burbidge Simon , Eckert Claire , Hancock Neil , Marshall Catriona , Rogerson Suzanne , Rossi Sabrina H. , Smith Andrew , Simmonds Irene , Wallace Tom , Ward Matthew , Callister Matthew E.J. , Stewart Grant D. 
Published: December 2023

ObjectivesTo evaluate psychological, social, and financial outcomes amongst individuals undergoing a non‐contrast abdominal computed tomography (CT) scan to screen for kidney cancer and other abdominal malignancies alongside the thoracic CT within lung cancer screening.Subjects and MethodsThe Yorkshire Kidney Screening Trial (YKST) is a feasibility study of adding a non‐contrast abdominal CT scan to the thoracic CT within lung cancer screening. A total of 500 participants within the YKST, comprising all who had an abnormal CT scan and a random sample of one‐third of those with a normal scan between 14/03/2022 and 24/08/2022 were sent a questionnaire at 3 and 6 months. Outcomes included the Psychological Consequences Questionnaire (PCQ), the short‐form of the Spielberger State–Trait Anxiety Inventory, and the EuroQoL five Dimensions five Levels scale (EQ‐5D‐5L). Data were analysed using regression adjusting for participant age, sex, socioeconomic status, education, baseline quality of life (EQ‐5D‐5L), and ethnicity.ResultsA total of 380 (76%) participants returned questionnaires at 3 months and 328 (66%) at 6 months. There was no difference in any outcomes between participants with a normal scan and those with abnormal scans requiring no further action. Individuals requiring initial further investigations or referral had higher scores on the negative PCQ than those with normal scans at 3 months (standardised mean difference 0.28 sd, 95% confidence interval 0.01–0.54; P = 0.044). The difference was greater in those with anxiety or depression at baseline. No differences were seen at 6 months.ConclusionScreening for kidney cancer and other abdominal malignancies using abdominal CT alongside the thoracic CT within lung cancer screening is unlikely to cause significant lasting psychosocial or financial harm to participants with incidental findings.
Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro
Authors: Grobbelaar Simone , Mercier Anne E. , van den Bout Iman , Durandt Chrisna , Pepper Michael S. 
Published: December 2023

AbstractThe generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from a number of different somatic sources, and have the capacity to differentiate into adipogenic, osteogenic, chondrogenic, and myogenic lineages. Although the first three have been extensively investigated, there remains a paucity of literature on the latter. This review looks at the various strategies available in vitro to enhance harvested MSC commitment and differentiation into the myogenic pathway. These include chemical inducers, myogenic‐enhancing cell culture substrates, and mechanical and dynamic culturing conditions. Drawing on information from embryonic and postnatal myogenesis from somites, satellite, and myogenic progenitor cells, the mechanisms behind the chemical and mechanical induction strategies can be studied, and the sequential gene and signaling cascades can be used to monitor the progression of myogenic differentiation in the laboratory. Increased understanding of the stimuli and signaling mechanisms in the initial stages of MSC myogenic commitment will provide tools with which we can enhance their differentiation efficacy and advance the process to clinical translation.
Barriers and facilitators to the implementation of the Flinders Chronic Condition Management Program in outpatient drug and alcohol settings in Australia
Authors: Oster Candice , Hunter Sarah , Schultz Timothy , Harvey Gillian , Lawless Michael , Battersby Malcolm 
Published: December 2023

AbstractIntroductionThere has been a growing call for drug and/or alcohol dependence to be managed as a chronic condition. The Flinders Chronic Condition Management Program (Flinders Program) was implemented in a drug and alcohol service in Australia in 2019–2022 to explore the feasibility of chronic condition management in outpatient clinics. Implementation involved: adaptation of the Flinders Program; adaptation of clinical procedures; training clinicians and managers; training Flinders Program Accredited Trainers; and system integration. This study aims to explore barriers and enablers to implementation.MethodsA qualitative formative evaluation was undertaken. Data included implementation documents (n = 7), responses to open‐ended questions in post‐training surveys (n = 27), and focus groups and interviews with implementation staff, clinicians, managers and a trainer (n = 16). Data were analysed using the Consolidated Framework for Implementation Research in a ‘coding reliability’ approach to thematic analysis.ResultsParticipants responded positively to the Flinders Program's philosophy, processes, tools and training. However, barriers were identified across three Consolidated Framework for Implementation Research domains: (i) outer setting (client suitability and incompatibility with external policies and incentives); (ii) characteristics of individuals (low self‐efficacy); and (iii) inner setting (lack of system and workflow integration).Discussion and ConclusionsExecutive support and systems integration are important for the implementation of the Flinders Program in drug and alcohol services. This needs to be achieved within externally mandated key performance indicators for outpatient services. Further research is needed to fully evaluate the potential of a chronic condition management framework in Australian outpatient drug and alcohol services.
Safety, pharmacokinetics and pharmacodynamics of HRS‐7535, a novel oral small molecule glucagon‐like peptide‐1 receptor agonist, in healthy participants: A phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose, and food effect trial
Authors: Wu Jingying , Zhou Renpeng , Zhang Qian , Zhang Qin , Qin Huiling , Ye Zi , Xu Yimei , Feng Sheng , Shu Chang , Shen Yu , Fan Yang , Wang Quanren , Du Yijun , Hu Wei 
Published: December 2023

AbstractAimTo assess the safety, tolerability, pharmacokinetics (PKs) and pharmacodynamics of HRS‐7535, a novel glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), in healthy participants.Materials and MethodsThis phase 1 trial consisted of single‐ascending dose (SAD), food effect (FE) and multiple‐ascending dose (MAD) parts. In the SAD part, participants were randomized (6:2) to receive HRS‐7535 (at doses of 15, 60 and 120 mg; administered orally once daily) or placebo. In the FE part, participants were randomized (8:2) to receive a single dose of 90‐mg HRS‐7535 or placebo, in both fed and fasted states. In the MAD part, participants were randomized (18:6) to receive daily HRS‐7535 (120 mg [30/60/90/120‐mg titration scheme]) or placebo for 28 days. The primary endpoints were safety and tolerability.ResultsNausea and vomiting were the most frequently reported AEs across all three parts. In the SAD part, the median Tmax was 5.98‐5.99 hours and the geometric mean t1/2 was 5.28‐9.08 hours across the HRS‐7535 dosing range. In the MAD part, the median Tmax was 5.98‐10.98 hours and the geometric mean t1/2 was 6.48‐8.42 hours on day 28 in participants on HRS‐7535. PKs were approximately dose‐proportional. On day 29 in the MAD part, the mean (percentage) reduction in body weight from baseline was 4.38 kg (6.63%) for participants who received HRS‐7535, compared with 0.8 kg (1.18%) for those participants who received a placebo.ConclusionsHRS‐7535 exhibited a safety and tolerability profile consistent with other GLP‐1RAs and showed PKs suitable for once‐daily dosing. These findings support further clinical development of HRS‐7535 for type 2 diabetes.
The joint determination of the payment method and the bid premium in M&As: What is the role of firm opacity?
Authors: Battigalli Pierpaolo , Chiarella Carlo , Gatti Stefano , Orlando Tommaso 
Published: December 2023

AbstractThis paper investigates how private information affects the joint determination of the payment method and the bid premium in M&As. The focus is on the uncertainty of the stand‐alone valuations of the firms involved in the transaction induced by their opacity. First, we model M&A negotiations as a signalling game with two‐sided private information and derive correlations between firm opacity and bid characteristics from equilibrium analysis. Then, we analyze a sample of U.S. deals, using an index based on market measures of adverse selection to quantify firm opacity. We find that the likelihood of stock offers and the bid premium increase with the target's opacity, while more opaque bidders are associated with fewer stock offers and smaller bid premiums.
Insertion sequence excision is enhanced by a protein that catalyzes branch migration and promotes microhomology‐mediated end joining
Authors: Kishino Ren , Saito Takashi , Muto Shuntaro , Tomita Yuzuka , Sekine Yasuhiko 
Published: December 2023

AbstractInsertion sequence (IS)‐excision enhancer (IEE) promotes the excision of ISs in the genome of enterohemorrhagic Escherichia coli O157. Because IEE‐dependent IS excision occurs in the presence of transposase, the process of IS transposition may be involved in IS excision; however, little is understood about the molecular mechanisms of IS excision. Our in vitro analysis revealed that IEE exhibits DNA‐dependent ATPase activity, which is activated by branched DNA. IEE also catalyzes the branch migration of fork‐structured DNA. These results suggest that IEE remodels branched structures of the IS transposition intermediate. Sequence analysis of recombination sites in IS‐excision products suggested that microhomologous sequences near the ends of the IS are involved in IS excision. IEE promoted microhomology‐mediated end joining (MMEJ), in which base pairing between 6‐nucleotides complementary ends of two 3′‐protruding DNAs and subsequent elongation of the paired DNA strand occurred. IS‐excision frequencies were significantly decreased in cells producing IEE mutants that had lost either branch migration or MMEJ activity, which suggests that these activities of IEE are required for IS excision. Based on our results, we propose a model for IS excision triggered by IEE and transposase.
Rhodamine B‐based lipase activity assay with natural substrates—development and application
Authors: Stemler Charlotte Dorothea , Lorenz Kim Karolin , Scherf Katharina Anne 
Published: December 2023

SummaryFor the various application fields of lipases in food, an accurate and reliable prediction of their performance is needed. This is not provided by the current artificial substrate‐based assays, because natural substrates should be applied. The fluorescent dye Rhodamine B (RB) enables the tracking of released fatty acids in real time and therefore offers the possibility to assess lipase activity towards any substrate. A high‐throughput assay including RB was established, validated and applied to a range of five fats/oils and two isolated lipids for a range of seven lipases. The results show that lipase reactions under different conditions are not comparable. Besides the substrate and the lipase, the milieu of the reaction has a decisive impact. For the prediction of lipase reactions in foods, further aspects such as the accessibility of substrates need to be taken into consideration.
Recent advances, challenges and functional applications of antifreeze protein in food industry
Authors: Xiao Shujian , Hu Shunyang , Zhu Kaixian , Bai Ting , Wang Wei , Cheng Jie , Zhang Jiamin 
Published: December 2023

SummaryFreezing is a common food preservation method that can extend the shelf life of food, but the ice crystals and recrystallisation during freezing, storage and transportation cause significant damage to frozen food. Antifreeze proteins are a class of proteins that widely exist in organisms living in cold conditions, such as fish, insects, plants and microorganisms in Antarctica and other cold regions. Antifreeze proteins can reduce the freezing point of water, inhibit recrystallisation effects, modify ice crystal morphology and effectively suppress the quality deterioration caused by ice crystals during food freezing. This review comprehensively introduces the source, antifreeze mechanism, application in food, influencing factors and regulating methods of antifreeze activity of antifreeze proteins, as well as the limitations of antifreeze proteins. It also looks forward to the future application of antifreeze proteins in food.