bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical investigation of photovoltaic solar system performance for a high-speed ship
Authors: Elkafas Ahmed G. 
Published: January 2024

Abstract
Maritime transportation has a remarkable contribution to the increase of pollutant gases in the atmosphere and adapting alternative energy systems to ship’s main power grid is an effective method to both save energy and reduce the amount of emission gases. The concept of green shipping is now becoming an important issue for ship owners, shipping lines, and shipbuilders globally. Solar energy may supply an environmentally friendly part of the total energy balance of a ship. Egypt is in the world’s solar belt and has excellent solar energy availability. Therefore, the present work aims to present a case study for installing a photovoltaic solar system onboard a passenger/Ro-Ro ship sailing between Safaga Port in Egypt and Yanbu Port in Saudi Arabia. Meteorological data for Safaga and Yanbu sailing route is presented to calculate the output power of that system. The proposed ship is designed to accommodate 843 passengers and 227 cars. The solar system onboard the ship has been modeled based on the available weather deck and bridge deck areas. The solar system will be composed of 1229 solar panels with 565 batteries. The proposed solar system will produce 1625 kWh/day used for the hoteling system of the ship. As a result of the calculations, 0.333 tons of low Sulphur fuel oil is saved in a day by the generators over the designed solar system. It is found significant environmental impacts within the calculation. By adopting such a solar system to the vessel, it is determined that there is a decrease of 0.27 tons of SOx, 7 tons of NOx, 415 tons of CO2, and 0.18 tons of PM emission that occur during the operations annually. A cost analysis is conducted to assess the economic benefits of the installed system. It shows that the proposed solar system will save 326,000 $ per year in addition to being clean to the environment, less emissions, and green ship.
Recent Approaches on Molecular Markers, Treatment and Novel Drug
Delivery System Used for the Management of Colorectal Cancer:
A Comprehensive Review
Authors: Chauhan Sonia , Sharma Sakshi 
Published: January 2024

:
Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third
most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection
and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics.
Novel potential agents have increased survival in acute and chronic disease conditions, with a
higher risk of side effects and cost. However, metastatic disease has an insignificant long-term
diagnosis, and significant challenges remain due to last-stage diagnosis and treatment failure.
Early detection, survival, and treatment efficacy are all improved by biomarkers. The advancement
of cancer biomarkers' molecular pathology and genomics during the last three decades
has improved therapy. Clinically useful prognostic biomarkers assist clinical judgment,
for example, by predicting the success of EGFR-inhibiting antibodies in the presence of
KRAS gene mutations. Few biomarkers are currently used in clinical settings, so further research
is still needed. Nanocarriers, with materials like Carbon nanotubes and gold nanoparticles,
provide targeted CRC drug delivery and diagnostics. Light-responsive drugs with gold
and silica nanoparticles effectively target and destroy CRC cells. We evaluate the potential use
of the long non-coding RNA (non-coding RNA) oncogene plasmacytoma variant translocation
1 (PVT1) as a diagnostic, prognostic, and therapeutic biomarker, along with the latest nanotech
breakthroughs in CRC diagnosis and treatment.
Efficacy and Safety of Phosphatidylinositol 3-kinase Inhibitors for
Patients with Breast Cancer: A Systematic Review and Meta-analysis of
Randomized Controlled Trials
Authors: Wang Yi , Du Xianling , Xin Hongqiang , Xu Ruimin 
Published: January 2024

Background::
Phosphatidylinositol 3-kinase (PI3K) inhibitors belong to the class of
drugs that inhibit the activity of the PI3K protein, which is commonly overexpressed in breast cancer
cells. However, there is a need to summarize the evidence to provide conclusive advice on the
benefit of PI3K inhibitors in breast cancer patients. Therefore, this review assessed the effectiveness
and safety of the PI3K inhibitors amongst breast cancer patients.

Methods::
Searches were made in PubMed Central, EMBASE, MEDLINE, SCOPUS, CENTRAL,
WHO trial registry and Clinicaltrials.gov up to December 2022. Meta-analysis was executed using
the random-effects model. Pooled hazard ratio (HR)/risk ratio (RR) was reported with 95% confidence
intervals (CIs).

Results::
In total, 13 studies were included in the analysis. Most were multi-country studies and
had a higher risk of bias. Regarding the efficacy parameters, pooled HR for progression-free survival
was 0.79 (95%CI: 0.67-0.92), pooled RR for complete response was 1.54 [95%CI: 1.14 to
2.09], partial response was 1.18 [95%CI: 0.87-1.61], overall response was 1.20 [95%CI:
0.93-1.56], stable disease was 1.09 [95%CI: 0.78-1.53], progressive disease was 0.80 [95%CI:
0.74 to 0.87], and clinical benefit was 1.08 [95%CI: 0.80-1.49]. For safety parameters, pooled RR
for hyperglycemia was 4.57 [95%CI: 3.15-6.62], and gastrointestinal toxicity was 1.82 [95%CI:
1.56 to 2.14].

Conclusion::
PI3K inhibitors had better efficacy than the present standard of concern for patients
with breast cancer, especially among patients with PIK3CA mutations. Hence, clinicians and oncologists
can provide this drug for the target population with extra caution for diabetes patients.
Schiff Bases: Versatile Mediators of Medicinal and Multifunctional
Advancements
Authors: Biswas Tanya , Mittal Ravi K. , Sharma Vikram , Kanupriya  , Mishra Isha 
Published: January 2024

Abstract:
This review aims to shed light on the profound implications of Schiff Bases in combating a
spectrum of pathogens by delving into their complex classification, synthesis, and reactions. The investigation
also covers the varied molecular properties of Schiff bases, highlighting their potential
use as chelating agents in coordination chemistry. Moreover, the investigation explores the discerning
nature of Schiff Bases about metal ions and their adeptness in establishing intricate associations,
highlighting their significance in metal coordination chemistry and specialized pharmaceutical
transport mechanisms. Moreover, the review delves into the synthetic capacity of Schiff Bases, highlighting
their importance in synthetic methodologies due to their exceptional adaptability, selectivity,
and structural similarity to organic compounds. The methodology employs a rigorous systematic literature
review to understand Schiff Bases comprehensively. This involves a meticulous analysis of
various research articles and publications, allowing for a comprehensive exploration of the topic. The
assessment of experimental investigations contributes to comprehending their molecular attributes,
specificity for metal ions, and capacity for synthesis. The presented analysis amalgamates a multitude
of sources to provide a nuanced and comprehensive viewpoint on the subject matter of Schiff Bases.
The findings underscore the multifaceted utility of Schiff Bases in the fight against pathogens, their
adaptability as chelating compounds, and their discerning affinity for metal ions. The examination of
synthesis highlights their profound importance in synthetic methodologies and their striking resemblance
to compounds found in living organisms. In conclusion, this analysis reveals Schiff Bases as
highly adaptable compounds with potential in antimicrobial therapy, coordination chemistry, and
precision drug delivery. The distinctive molecular attributes of these substances, functioning as chelators,
contribute to their notable importance. The ability of Schiff bases to form complexes and their
preference for metal ions highlight the wide range of applications for these molecules. Schiff Bases
have a transformative effect on chemistry and medicine as we investigate their synthetic potential,
driven by their versatility and structural similarity to biological compounds.
Emerging Phytochemicals to Treat Leishmaniasis: A Review of
Experimental Studies from 2011 to 2021
Authors: Namdeo Madhulika , Veronica Jalaja , Kumar Krishan , Anand Anjali , Maurya Radheshyam 
Published: January 2024

:
Leishmaniasis is a protozoan disease caused by a parasite from the genus Leishmania.
It is known as a neglected tropical disease by WHO and is the second-leading cause of death by
parasites after malaria. Chemotherapy is the only effective way to control the disease, but
treatment options for leishmaniasis are limited. The majority of the drugs are costly, have serious
side effects and necessitate hospitalisation. The lack of an effective vaccine, in addition to the
emergence of resistance to currently available drugs, has all been raised as major concerns,
especially in endemic areas of developing countries. Phytochemicals might contribute to the
development of novel and effective drugs for the treatment of leishmaniasis by providing
selectively targeted intervention in parasites. Many phytochemicals (quinones, alkaloids,
terpenes, saponins, phenolics) and their derivatives are quite active against diverse groups of
pathogens, such as viruses, bacteria, fungi and parasites. To date, many phytochemicals have
shown potent anti-leishmanial activity with highly selective mode of action. However, due to a
lack of interaction between academician and pharma industries none of them has undergone the
clinical assessment. The present review will analyse the most promising phytochemicals and their
synthetic compounds, which have shown antileishmal activity in in-vitro and subsequently in
animal studies from 2011-2021. These phytochemicals are apigenin, hydroxyflavanone,
Epigallocatechin-O-3 gallate, caffeic acid, α-bisabolol, β-caryophyllene, ursolic acid, quinones,
which have shown notable anti-leishmanial activities in several independent studies.
Natural Alkaloids and Mechanisms for Anti-cancer Action: A Review
Authors: Mishra Prem Shankar , Kaushik Niranjan , Mishra Rakhi , Koul Sameeksha , Sagar Sakshi 
Published: January 2024

:
Cancer is a global public health issue. Cancer therapy has been hampered by the issue
of multidrug resistance, which is one of the leading causes of death worldwide. As a result, the
use of natural derived drugs for cancer prevention and therapy has been researched and developed
for decades. Alkaloids are plant-derived secondary metabolites that have antiproliferative and
anticancer effects on several forms of cancer. Camptothecin and vinblastine, two anticancer medicines
derived from alkaloids, have been adequately developed in the past. Alkaloids, a drug lead
compounds, derived from natural products, have the advantage of being used by the host, making
them suitable for further exploitation. The current review looks at the anticancer potential of numerous
naturally occurring alkaloids, as well as the mechanism behind their anticancer effect.
Pt(IV) Complexes with Biologically Active and Physicochemical Properties
Modifier Ligands
Authors: Aher Sainath , Zhu Jinhua , Liu Xiuhua , Borse Laxmikant 
Published: January 2024

:
The octahedral Pt(IV) complexes contain either inert or biologically active ligands
where the nature of these axial ligands provides additional stability and synergistic biological activity.
There are many literature reports from each of the classes mentioning the varied nature of
these axial ligands. The targeting, as well as the non-targeting nature of these moieties, exerts
additive or synergistic effects of anticancer activity of Pt(II) moieties. Herein, we have discussed
the effects of these axially oriented ligands, changes in the non-leaving am(m)ine groups, and
changes in the leaving groups on the biological activity. In this review, we have discussed the
axial ligands with a focus on the nature of the ligands and alterations in biological activities.
The Role of Long Noncoding RNAs in Progression of Leukemia: Based on
Chromosomal Location
Authors: Sabaghi Fatemeh , Sadat Saina Yousefi , Mirsaeedi Zohreh , Salahi Aref , Vazifehshenas Sara , Kesh Neda Zahmat , Balavar Mahdieh , Ghoraeian Pegah 
Published: January 2024

Abstract:
Long non-coding RNA [LncRNA] dysregulation has been seen in many human cancers, including several kinds of leukemia, which is still a fatal disease with a poor prognosis. LncRNAs have been demonstrated to function as tumor suppressors or oncogenes in leukemia. This study covers current research findings on the role of lncRNAs in the prognosis and diagnosis of leuke-mia. Based on recent results, several lncRNAs are emerging as biomarkers for the prognosis, di-agnosis, and even treatment outcome prediction of leukemia and have been shown to play critical roles in controlling leukemia cell activities, such as proliferation, cell death, metastasis, and drug resistance. As a result, lncRNA profiles may have superior predictive and diagnostic potential in leukemia. Accordingly, this review concentrates on the significance of lncRNAs in leukemia pro-gression based on their chromosomal position.
Glucose-Water Synergy: An Organocatalytic System Driven synthesis of
Benzimidazolo[2,3-b]quinazolinone and Benzothiazolo[2,3-b]quinazolinone
Derivatives
Authors: Baranwal Jyoti , Singh Swastika , Kushwaha Smriti , Jyoti Archana 
Published: January 2024

Introduction:
A simple and efficient one-pot synthesis of quinazolinone derivatives has
been developed via a multicomponent reaction (MCR) involving the condensation of dimedone,
benzaldehyde, and 2-aminobenzimidazole/2-aminobenzothiazole.

Method:
In this work, glucose water is used as a green, reusable, environmentally benign organocatalytic
solvent system to synthesize desired products.

Result:
The main benefits of this one-pot method include its excellent yields, less time, cost-effectiveness,
atom economy, environment benign, and easy workup.

Conclusion:
In conclusion, we successfully developed a green protocol for the environmentally
benign synthesis of benzimidazo/benzothiazolo quinazolinones using glucose water as an organocatalytic
medium.
Hydrogel for the Treatment of Diabetic Wounds: A Comprehensive Review
Authors: Bhattacharyya Soubhik , Sarkar Dhrubajyoti , Bora Devanjal , Gautam Manish Kumar 
Published: January 2024

Abstract:
The management of chronic wounds in diabetic patients is a tough challenge, compounded by elevated amputation rates, frequent recurrence, and increased mortality rates. Nonhealing wounds in people with diabetes are produced by a combination of variables that impede
the clearance of injured tissue, stimulate the formation of healthy cell populations, and increase
the risk of infection. Traditional wound dressings, such as gauze, films, and bandages, focused
solely on hydration and infection prev ention. However, recent scientific investigation has shifted toward advancements in wound healing treatments to overcome the constraints inherent in old
methodologies. Hydrogel dressings have surfaced as a particularly enticing and promising avenue for increasing wound healing prowess in the modern medical environment, owing to their
remarkable ability for moisture retention, biocompatibility profiles, and therapeutic attributes.
The pathophysiology of diabetes wounds has been better studied in recent decades, and a range
of functionalized hydrogel dressings have been reported with favourable outcomes, indicating
that they have significant potential in healing diabetic wounds. Our approach will comprise a
systematic and comprehensive evaluation of the advancements in hydrogel dressing methods
related to diabetic wounds. This review presents a strong theoretical foundation for advancing
hydrogel dressing technologies and offers suggestions for treating diabetic wound-related problems.
Insights into Prospects of Novel NSAID Prodrugs in the Management of
Gastrointestinal Toxicity: A Perspective Review
Authors: Goyal Rajat , Gupta Sumeet , Sharma Prabodh , Sharma Manu 
Published: January 2024

Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) have a long history in the
healthcare system due to their therapeutic potential. These NSAIDs cause ulcerogenicity, stomach
pains, gastrointestinal hemorrhage, mucosa bleeding, and pancreatitis when used moderately
and consistently. With researchers, managing the aforementioned adverse effects therapeutically
is getting increasingly difficult. One method for creating NSAID moieties with low penetration
as well as ulcerogenic properties is the prodrug technique. During the oral consumption
of NSAID-prodrugs, ulcerations, intestinal hemorrhage, and mucosa hemorrhage have significantly
decreased. Considering this background, this review focussed on NSAID prodrugs as
well as their justifications, the pathogenesis of NSAIDs inducing gastrointestinal toxicity, and
the role of different antioxidants and spacer groups. Prodrug moieties have more advantages
over parent medicines concerning both solubility and lipophilicity. In general, NSAID-class
prodrugs can successfully treat both acute and long-term inflammation and aches without causing
ulcerotoxicity and related gastrointestinal side effects, which reduces their burden from the
pharmacoeconomic perspective.
Entre o antipetismo e a terceira via
Authors: Alves Mércia , Martins Joyce Miranda Leão 
Published: January 2024

O Horário Gratuito de Propaganda Eleitoral (HGPE) é uma das variáveis explicativas do voto no Brasil. Em 2018, a campanha na TV teve a duração reduzida e passou a coexistir com outros espaços de comunicação. Nesse contexto, o objetivo do artigo é verificar as estratégias discursivas mobilizadas por Geraldo Alckmin para se colocar como alternativa viável às candidaturas de PSL e PT, que lideraram a corrida presidencial no primeiro turno. O corpus empírico são os programas do HGPE e os spots do candidato à Presidência da República pelo PSDB. O método utilizado é a Análise do Discurso. Argumentamos que, em um ambiente com grande polarização, a imagem de uma oposição moderada foi rejeitada. Foram dois os sentidos mobilizados na construção do ethos de Alckmin: de melhor opção ao antipetismo à “terceira via” entre as candidaturas de Haddad e Bolsonaro. Posteriormente, rende-se ao "antipetismo emocional" e afirma que só o PSDB venceria o PT no segundo turno.
Inhibitory Control Training for Anxiety and Math Achievement in Primary School Children: Protocol for a Proof-of-Concept Study
Authors: Edwards Elizabeth , Chu Khanh Linh , Carroll Annemaree 
Published: January 2024

Background
Cognitive control training (CCT) has shown potential to reduce emotional vulnerability in adults and adolescents. However, there is scant literature testing the efficacy of CCT for the reduction of anxiety and transferring the effects to educational outcomes in children. Building on the evidence that a greater ability to suppress a prepotent response (inhibitory control) is associated with higher math achievement in children, it is plausible that training inhibitory processes using a CCT paradigm may be beneficial for reducing anxiety, improving inhibitory control, and in turn increasing math achievement.

Objective
This proof-of-concept study aims to investigate the efficacy of 15 sessions of inhibitory control training for reduction in anxiety and improvement in math achievement in primary school children.

Methods
We will use a 2 (group: CCT, adaptive Go/No-Go vs active control, low-load task) multiplied by 4 (time: pre- vs posttraining vs 1-month vs 3-month follow-up) randomized design in a nonselected sample of 100 children aged 8-10 years. Both groups will complete 10 minutes of daily training for 3 weeks at school. The dependent variables will be anxiety and correlates (Spence Children’s Anxiety Scale, Penn State Worry Questionnaire for Children, Revised Children’s Anxiety and Depression Scale, Child Response Style Questionnaire, and Modified Abbreviated Math Anxiety Scale), inhibitory control (Go/No-Go task), shifting (color-shape shifting task), updating (n-back task), and math achievement (Applied Problems, Calculation, and Math Facts Fluency subtests from the Woodcock-Johnson IV Tests of Achievement).

Results
We opened enrollment in September 2023. The initial results are expected to be published in late 2024. We predict that children in the CCT group will show a reduction in emotional symptoms; improvements in inhibition, shifting, and updating performance; and advances in math achievement from pre- to posttraining, and that these effects will be maintained at 1- and 3-month follow-ups, compared to children in the active control group.

Conclusions
The CCT paradigm used in our study will provide a greater understanding of the emotional and cognitive transfer effects on children and inform future work. Specifically, the findings will advance the knowledge of deploying inhibitory control training with children and provide valuable insights into its use for reducing anxiety and advancing math achievement.

Trial Registration
Open Science Framework ofs.io/de2qa; https://doi.org/10.17605/OSF.IO/DE2QA

International Registered Report Identifier (IRRID)
PRR1-10.2196/52929
Enfermedad de Puigvert: un caso raro
Authors: Guerrero Tinoco Gustavo Adolfo , Moreno Maya Diana Paola 
Published: January 2024

Introducción: la enfermedad de Puigvert, o megacaliosis, es un trastorno congénito del sistema colector urinario poco frecuente, caracterizado por la dilatación de los calices renales sin dilación del tracto urinario.
Objetivo: el propósito de este artículo es informar el caso de enfermedad de Puigvert o megacaliosis identificada en un lactante menor de tres meses de edad.
Presentación del caso: en este artículo se reporta el caso de un lactante menor con megacaliosis bilateral en quien se realizó el diagnóstico posnatal, a partir de una presunción diagnóstica prenatal de riñón multiquístico.
Discusión y conclusión: esta es una entidad rara con pocos casos reportados a nivel mundial, de curso benigno que representa un factor de riesgo para el desarrollo de complicaciones secundarias, por lo cual es fundamental la identificación temprana, así como el descartar otros diagnósticos diferenciales, entre ellos la dilatación del tracto urinario (DTU), la cual fue sospechada inicialmente en nuestro paciente. En el caso del lactante de este reporte, el diagnóstico temprano pudo realizarse gracias a las pruebas imagenológicas prenatales que permitieron la sospecha diagnóstica de una anormalidad renal con posterior confirmación en la ecografía posnatal; en el seguimiento, el paciente se ha mantenido asintomático sin evidencia de complicaciones.