bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controls of lithology and climate over chemical weathering trends: new insights from the precipitation-dominated Dokriani glacier, central Himalaya, India
Authors: Sundriyal Shipika , Shukla Tanuj , Kang Shichang , Zhang Yulan , Dobhal Dwarika Prasad , Singh Rajesh 
Published: January 2024

Abstract
The chemical composition of meltwater-draining Himalayan glacierized basins reflects the dominance of carbonic acid in weathering of silicate and carbonate minerals, yet the role of sulfuric acid-mediated reactions in the mineral weathering and ionic release is still unclear. Here, we present a long-term study (1992–2018) of chemical weathering characteristics of a precipitation-dominated glacierized basin (Dokriani glacier) of central Himalaya. By using new and reprocessed datasets of major ions from the glacial/subglacial zones of the glacier, we suggest that two-thirds of the dissolved load of the meltwater derives from sulfuric acid-mediated weathering of minerals and rocks. We observed a clear control of carbonic acid-mediated reactions in the early ablation periods, while sulfuric acid-mediated reactions dominate in peak and late ablation periods. The slopes and intercepts in best-fit regressions of [*Ca2+ + *Mg2+ vs *SO42− and HCO3−] and [HCO3− vs *SO42−] in meltwater were following the stoichiometric parameters of sulfide oxidation coupled to carbonate dissolution reactions. The glaciers of the central and western Himalaya are in good agreement with the present estimates. We contend that the bedrock lithology has limited or second-order effects over the ionic release from Himalayan glaciers and surmise that these patterns are broadly applicable to the other orogenic systems of the world.
Sharp large deviations and concentration inequalities for the number of descents in a random permutation
Authors: Bercu Bernard , Bonnefont Michel , Richou Adrien 
Published: January 2024

AbstractThe goal of this paper is to go further in the analysis of the behavior of the number of descents in a random permutation. Via two different approaches relying on a suitable martingale decomposition or on the Irwin–Hall distribution, we prove that the number of descents satisfies a sharp large-deviation principle. A very precise concentration inequality involving the rate function in the large-deviation principle is also provided.
Association between sleep duration and quality with food intake, chrononutrition patterns, and weight gain during pregnancy
Authors: Silveira Noara Carvalho , Balieiro Laura Cristina Tibiletti , Gontijo Cristiana Araújo , Teixeira Gabriela Pereira , Fahmy Walid Makin , Maia Yara Cristina de Paiva , Crispim Cibele Aparecida 
Published: January 2024

AbstractTo analyse the association between sleep duration and quality with food intake, chrononutrition patterns, and weight gain during pregnancy. A prospective cohort study was conducted with 100 pregnant women. Data collection occurred once during each gestational trimester. The assessment of sleep quality and duration was performed using the Pittsburgh Sleep Quality Index. Food intake was assessed using three 24-h recalls in each trimester. Body weight was measured during the three trimesters, and height was measured only once to calculate the BMI. Linear regression analyses were performed to associate sleep duration and quality with food consumption and weight gain variables. Longer sleep duration was associated with a later dinner in the first trimester (β = 0·228, P = 0·025) and earlier in the third trimester (β = –0·223, P = 0·026), in addition to a later morning snack in the second trimester (β = 0·315, P = 0·026). Worse sleep quality was associated with higher total energy intake (β = 0·243, P = 0·044), total fat (β = 0·291, P = 0·015) and the chrononutrition variables such as a higher number of meals (β = 0·252, P = 0·037), higher energetic midpoint (β = 0·243, P = 0·044) and shorter fasting time (β = –0·255, P = 0·034) in the third trimester. Sleep quality was also associated with a higher BMI in the first trimester of pregnancy (β = 0·420, P = < 0·001). Most of the associations found in the present study show that poor sleep is associated with higher energy and fat intake and higher BMI. Longer sleep duration was associated with a later dinner in early pregnancy and an earlier dinner in late pregnancy, as well as with a later morning snack in the second trimester of pregnancy.
Caregivers’ concerns through health professionals’ eyes
Authors: Oliveira Carolina , Lourenço Daniela , Sotero Luciana , Relvas Ana Paula 
Published: January 2024

AbstractObjectivesAdvancements in medicine and science have enabled more and more people to live longer with a chronic medical condition, namely cancer. Nevertheless, the palliative care (PC) approach continues to be introduced and incorporated later in the lives of patients and families dealing with such conditions. Thus, the need for individuals to care for this population in our society is increasing, giving rise to the so-called “informal caregivers.” The present study intends to examine the main obstacles faced by informal caregivers taking care of a cancer patient receiving PC based on what health professionals working in these settings perceive and write down. To achieve this goal, the written files of 2 Portuguese palliative care institutions were analyzed.MethodsAn inductive thematic analysis was conducted, focusing on the contact between health professionals and family caregivers and based on the notes taken by health professionals.ResultsThree main overarching themes were identified: (1) burden, (2) intra-family impact of the illness, and (3) network vulnerabilities. Included in this are the emphasis on the role of the family and social support, the high levels of psychological morbidity and caregiver burden present over this period, and a great need for information about the illness.Significance of resultsThis study provided a broader awareness regarding the daily struggle experienced by family caregivers, particularly those who juggle between “roles.” It is vital to understand the scope of the obstacles experienced by caregivers during the terminal phase of their loved one’s illness, given how important it is to address the family’s needs. Future studies and practitioners should consider these observations and topics when considering new approaches for this population, as they ought to be quite focused and short in time in order to meet people’s needs.
Nonparametric intercept regularization for insurance claim frequency regression models
Authors: Lee Gee Y. , Jeong Himchan 
Published: January 2024

AbstractIn a subgroup analysis for an actuarial problem, the goal is for the investigator to classify the policyholders into unique groups, where the claims experience within each group are made as homogenous as possible. In this paper, we illustrate how the alternating direction method of multipliers (ADMM) approach for subgroup analysis can be modified so that it can be more easily incorporated into an insurance claims analysis. We present an approach to penalize adjacent coefficients only and show how the algorithm can be implemented for fast estimation of the parameters. We present three different cases of the model, depending on the level of dependence among the different coverage groups within the data. In addition, we provide an interpretation of the credibility problem using both random effects and fixed effects, where the fixed effects approach corresponds to the ADMM approach to subgroup analysis, while the random effects approach represents the classic Bayesian approach. In an empirical study, we demonstrate how these approaches can be applied to real data using the Wisconsin Local Government Property Insurance Fund data. Our results show that the presented approach to subgroup analysis could provide a classification of the policyholders that improves the prediction accuracy of the claim frequencies in case other classifying variables are unavailable in the data.
Emission Factors From Wildfires in the Western US: An Investigation of Burning State, Ground Versus Air, and Diurnal Dependencies During the FIREX‐AQ 2019 Campaign
Authors: Fiddler Marc N. , Thompson Chelia , Pokhrel Rudra P. , Majluf Francesca , Canagaratna Manjula , Fortner Edward C. , Daube Conner , Roscioli Joseph R. , Yacovitch Tara I. , Herndon Scott C. , Bililign Solomon 
Published: January 2024

AbstractEmission factors (EFs) are crucial in understanding the effects of wildfire emissions on air quality. We examined the variability of EFs of three wildfires (Nethker, Castle, and 204 Cow) during the 2019 Western US wildfire season using the Aerodyne Mobile Laboratory (AML) and compared them to previous studies. The AML sampling captured the high degree of variability present in wildfires, and we report results for a range of combustion conditions that is more extensive than previous field and laboratory studies. For instance, we captured emissions from freshly started flaming fuels and we report rare EF measurements at very high modified combustion efficiencies (MCEs); MCEs >0.9. Differences in emissions between AML‐observed wildfires were attributed to burning state/MCE rather than fuel type. A comparison of EFs versus MCE was made and linear fits were compared to previous observations to reveal important differences that incorporate these high MCEs. For some species, there remains an EF dependence on MCE at these high values, while others reach a minimum value and exhibit either no or a weak dependence above it. EF differences were found for many of the studied compounds when comparing ground‐based and airborne observations, with generally greater airborne EFs possibly due to photochemical oxidation. The largest differences were from monoterpenes and acetaldehyde. Comparisons were made between AML‐observed wildfires, aircraft observations, and the values in literature for EFs and emission ratios, with mixed agreement due to the high degree of variability caused by differences in MCE. Differences in MCE drove the diurnal EF differences.
Tropical Cirrus Are Highly Sensitive to Ice Microphysics Within a Nudged Global Storm‐Resolving Model
Authors: Atlas R. L. , Bretherton C. S. , Sokol A. B. , Blossey P. N. , Khairoutdinov M. F. 
Published: January 2024

AbstractCirrus dominate the longwave radiative budget of the tropics. For the first time, the variability in cirrus properties and longwave cloud radiative effects (CREs) that arises from using different microphysical schemes within nudged global storm‐resolving simulations from a single model, is quantified. Nudging allows us to compute radiative biases precisely using coincident satellite measurements and to fix the large‐scale dynamics across our set of simulations to isolate the influence of microphysics. We run 5‐day simulations with four commonly‐used microphysics schemes of varying complexity (SAM1MOM, Thompson, M2005 and P3) and find that the tropical average longwave CRE varies over 20 W m−2 between schemes. P3 best reproduces observed longwave CRE. M2005 and P3 simulate cirrus with realistic frozen water path but unrealistically high ice crystal number concentrations which commonly hit limiters and lack the variability and dependence on frozen water content seen in aircraft observations. Thompson and SAM1MOM have too little cirrus.
Process‐Informed Subsampling Improves Subseasonal Rainfall Forecasts in Central America
Authors: Kowal Katherine M. , Slater Louise J. , Li Sihan , Kelder Timo , Hall Kyle J. C. , Moulds Simon , García‐López Alan A. , Birkel Christian 
Published: January 2024

AbstractSubseasonal rainfall forecast skill is critical to support preparedness for hydrometeorological extremes. We assess how a process‐informed evaluation, which subsamples forecasting model members based on their ability to represent potential predictors of rainfall, can improve monthly rainfall forecasts within Central America in the following month, using Costa Rica and Guatemala as test cases. We generate a constrained ensemble mean by subsampling 130 members from five dynamic forecasting models in the C3S multimodel ensemble based on their representation of both (a) zonal wind direction and (b) Pacific and Atlantic sea surface temperatures (SSTs), at the time of initialization. Our results show in multiple months and locations increased mean squared error skill by 0.4 and improved detection rates of rainfall extremes. This method is transferrable to other regions driven by slowly‐changing processes. Process‐informed subsampling is successful because it identifies members that fail to represent the entire rainfall distribution when wind/SST error increases.
Relationships Between Land Use and Terrestrial Organic Matter Transfer to the Baltic Sea Over the Last 500 Years
Authors: Yang Bingjie , Ljung Karl , Ning Wenxin , Filipsson Helena L. , Nielsen Anne Birgitte 
Published: January 2024

AbstractTerrestrial organic matter (OM) plays a key role in coastal organic carbon burial. However, few studies focus on the relationship between land use in the watershed and the transport of terrestrial OM to coasts from a long‐term perspective. In this study, we compared terrestrial OM deposition between an inlet of the Baltic Sea and an upstream lake within the same watershed over the last 500 years, using lignin biomarkers in the sediments. In combination with pollen‐based quantitative land cover reconstruction, we assessed the impacts of semicentennial‐scale changes in land use on terrestrial OM export. The results indicated that the concentration, composition, and degradation state of the lignin‐derived OM differed substantially between the two sites. The lake received larger amounts of lignin‐derived OM during periods of intensified agriculture, but the coastal site did not. The composition of lignin in the coastal sediment did not directly reflect variations in vegetation cover in the watershed. The reason could be that the OM was settled in the upstream basins. Furthermore, the terrestrial OM that did reach the coastal sediments was modified through degradation during the transport, and only the refractory component was deposited at the coast in a relatively unaltered form.
Extending Active Network Length Versus Catchment Discharge Relations to Temporarily Dry Outlets
Authors: Botter Gianluca , McNamara James , Durighetto Nicola 
Published: January 2024

AbstractRiver networks are not steady blue lines drawn in a map, since they continuously change their shape and extent in response to climatic drivers. Therefore, the flowing length of rivers (L) and the corresponding catchment‐scale streamflow (Qsur) co‐evolve dynamically. This paper analyzes the relationship between the wet channel length and the streamflow of a river basin, formulating a general analytical model that includes the case of temporarily dry outlets. In particular, the framework relaxes the common assumption that when the discharge at the outlet tends to zero the upstream flowing length approaches zero. Different analytical expressions for the L(Qsur) law are derived for the cases of (a) a perennial outlet; (b) a non‐perennial outlet that dries out only when the whole network is dry; and (c) a temporarily dry outlet, that experiences surface flow for less time than other network nodes. In all cases, the shape of the L(Qsur) relationship is controlled by the distribution of the specific subsurface discharge capacity along the network. For temporarily dry outlets, however, the relation between L and Qsur might depend on an unknown shifting factor. Three real‐world examples are presented to demonstrate the flexibility and the robustness of the theory. Our results indicate that the whole shape of the L(Qsur) relation might not be empirically observable if a significant fraction of the network is perennial or some reaches in the network experience surface flow for longer than the discharge gauging station. The study provides a basis for integrating empirical L(Qsur) data gathered in diverse sites.
Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
Authors: Park Eun-Ji , Lee Chang-Woo 
Published: January 2024

AbstractSoluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets. We provide an overview of the mechanisms by which soluble receptors are generated along with their functions. By exploring their involvement in cancer progression, metastasis, and immune evasion, we highlight the importance of soluble receptors, particularly soluble cytokine receptors and immune checkpoints, in the tumor microenvironment. Although current research has illustrated the emerging clinical relevance of soluble receptors, their therapeutic applications remain underexplored. As the landscape of cancer treatment evolves, understanding and targeting soluble receptors might pave the way for novel strategies for cancer diagnosis, prognosis, and therapy.
Twisted microdomains in liquid crystals for polarization-insensitive phase modulation
Authors: Ma Yifei , Zhao Zimo , Morris Stephen M. , He Chao 
Published: January 2024

AbstractPolarization-independent phase modulators based upon liquid crystals (LCs) with a simple device architecture have long been desired for a range of optical applications. Recently, researchers have demonstrated a novel fabrication procedure using cholesteric LCs as a primer for achieving low polarization dependence coupled with a large phase modulation depth.
Cavity-enhanced photoacoustic dual-comb spectroscopy
Authors: Wang Zhen , Nie Qinxue , Sun Haojia , Wang Qiang , Borri Simone , De Natale Paolo , Ren Wei 
Published: January 2024

AbstractPhotoacoustic dual-comb spectroscopy (DCS), converting spectral information in the optical frequency domain to the audio frequency domain via multi-heterodyne beating, enables background-free spectral measurements with high resolution and broad bandwidth. However, the detection sensitivity remains limited due to the low power of individual comb lines and the lack of broadband acoustic resonators. Here, we develop cavity-enhanced photoacoustic DCS, which overcomes these limitations by using a high-finesse optical cavity for the power amplification of dual-frequency combs and a broadband acoustic resonator with a flat-top frequency response. We demonstrate high-resolution spectroscopic measurements of trace amounts of C2H2, NH3 and CO in the entire telecommunications C-band. The method shows a minimum detection limit of 0.6 ppb C2H2 at the measurement time of 100 s, corresponding to the noise equivalent absorption coefficient of 7 × 10−10 cm−1. The proposed cavity-enhanced photoacoustic DCS may open new avenues for ultrasensitive, high-resolution, and multi-species gas detection with widespread applications.
The role of inflammasomes in human diseases and their potential as therapeutic targets
Authors: Yao Jing , Sterling Keenan , Wang Zhe , Zhang Yun , Song Weihong 
Published: January 2024

AbstractInflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein ASC. Inflammasome formation typically occurs in response to infectious agents or cellular damage. The active inflammasome then triggers caspase-1 activation, followed by the secretion of pro-inflammatory cytokines and pyroptotic cell death. Aberrant inflammasome activation and activity contribute to the development of diabetes, cancer, and several cardiovascular and neurodegenerative disorders. As a result, recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation, as well as the potential of targeting inflammasomes to treat various diseases. Multiple clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting therapies. Therefore, understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic strategies. In this article, we provide a summary of the biological and pathological roles of inflammasomes in health and disease. We also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.
The efficacy of various irrigation techniques on the removal of double antibiotic paste from simulated immature roots and the amount of apically extruded debris
Authors: Nasr El-Din Shaimaa , Hassan Reham 
Published: January 2024

Abstract
Objective
This study evaluated the effect of the XP-Endo Finisher (XPF), passive ultrasonic irrigation (PUI) and conventional irrigation using side-vented needle (SVN) on the amount of apically extruded debris and canal cleanliness following the removal of double antibiotic paste (DAP) from immature root canal models.

Material and methods
Forty-eight extracted mandibular premolars were drilled using peeso drills to simulate immature apices. The canals were filled with DAP and were randomly assigned into 3 groups according to the DAP removal method: XPF, PUI, and SVN (n = 16). The amount of extruded debris was assessed with an analytical balance then roots were split longitudinally and imaged using stereomicroscope to evaluate the residual medicament. Data were statistically analyzed using Kruskal-Wallis and Dunn’s test. Spearman’s correlation coefficient was used to determine significant correlation between extruded debris and the residual DAP scores.

Results
There was no significant difference between debris extrusion values for all groups (P value 0.237). For canal cleanliness, the amount of remaining DAP was significantly lower in the XPF and PUI compared to SVN (P value < 0.001). A non-significant positive (direct) correlation was found between the amounts of apically extruded debris and residual DAP scores (P value 0.087).

Conclusion
XPF and PUI were associated with better canal cleanliness during removal of DAP, no difference could be found between the three irrigation techniques regarding the debris extrusion.
Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer
Authors: Zhu Qingyun , Dai Qiuzi , Zhao Lei , Zheng Chang , Li Qinyuan , Yuan Zigao , Li Lulu , Xie Zhuoye , Qiu Zixuan , Huang Wenjun , Liu Guowen , Zu Xuyu , Chu Bizhu , Jiang Yuyang 
Published: January 2024

AbstractPARP inhibitors and HDAC inhibitors have been approved for the clinical treatment of malignancies, but acquired resistance of or limited effects on solid tumors with a single agent remain as challenges. Bioinformatics analyses and a combination of experiments had demonstrated the synergistic effects of PARP and HDAC inhibitors in triple-negative breast cancer. A series of novel dual PARP and HDAC inhibitors were rationally designed and synthesized, and these molecules exhibited high enzyme inhibition activity with excellent antitumor effects in vitro and in vivo. Mechanistically, dual PARP and HDAC inhibitors induced BRCAness to restore synthetic lethality and promoted cytosolic DNA accumulation, which further activates the cGAS–STING pathway and produces proinflammatory chemokines through type I IFN-mediated JAK–STAT pathway. Moreover, these inhibitors promoted neoantigen generation, upregulated antigen presentation genes and PD-L1, and enhanced antitumor immunity when combined with immune checkpoint blockade therapy. These results indicated that novel dual PARP and HDAC inhibitors have antitumor immunomodulatory functions in triple-negative breast cancer.