bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transport parameter effects on controlling formation and shape of lotus-type pores in solid
Authors: Wei P S , Ou Y T 
Published: January 2025

Abstract
This study explores sufficient conditions based on transport parameters to effectively manipulate the growth and shape of lotus pores during solidification. Specifically, spatial variations in mass transfer coefficients and solute transport parameters are considered. Solute transport is the key factor responsible for the evolution of lotus pores. The work investigates the influence of these conditions on the shape development of lotus pores, which find applications in diverse fields such as energy absorption, sound absorption, shock and vibration damping, heat sinks, filters and tissue and bone implants. The unsteady gas pressure within the pores, responsible for bubble entrapment, is influenced by gas, capillary and liquid pressures, as well as Sieverts’ or Henry's laws, and solute transfer at gas–liquid interfaces. Solute transport into the pore is determined by liquid convection as well as convection-affected segregation at the advancing liquid–solid interface. The study utilizes the MATLAB code to solve the resulting first-order time-derivative ordinary differential equations. It shows that the lotus pores are susceptible to entrapment as the mass transfer coefficient at a contact angle of 90° increases, while the solute transport parameters at the initial time and a contact angle of 90° decrease. The lotus pore length increases and decreases, respectively, with increases in the mass transfer coefficients as well as the solute transport parameter at the initial time and a contact angle of 90°. Predicted lotus pore shapes align closely with algebraic results, validated by experimental data from a prior study.
Investigation on the dynamic characteristics of gears considering spatial crack propagation
Authors: Zhao Jiang , Niu Ruopu , Wu Yue , Yu Xiaofeng , Sheng Wei 
Published: January 2025

Abstract
Considering the failure of gear space cracks caused by uneven load distribution, local material defects and installation errors, the effect of gear crack space propagation path on dynamic characteristics was investigated based on the extended finite element model and gear dynamics model. The effect of the initial crack location and angle on the extent of crack expansion and the dynamic characteristics of the gear was discussed, and experimental verification was conducted. The results demonstrated that with the expansion of the spatial crack, the time-varying meshing stiffness TVMS gradually decreases, which leads to the periodic impact response of the dynamic meshing force and dynamic transmission error, and sidebands appear around the meshing frequency and harmonic components. Furthermore, the location and angle of the initial crack lead to different crack propagation paths in space, which in turn lead to different variations of gear dynamic characteristics.
How Are the Gentiles Changed? The Influence of Micah on the Animal Apocalypse and Revelation 21–22
Authors: Korpman Matthew J 
Published: January 2025

Abstract
In this paper, I argue that the end of the Animal Apocalypse bears a striking resemblance to Micah 4:1–5 and Isa. 19:18–25. This text appears to answer the dilemma that Micah and Isaiah create: how will the Gentiles stop being violent and what will prevent them from becoming violent again? It is argued that the White Bull, rather than being an expected future Messiah figure (as popularly believed), likely represents a righteous Gentile who is necessary for ensuring the answer to this dilemma. It is also argued that the Book of Revelation’s ending resonates with both Micah and 1 Enoch, suggesting that John’s Apocalypse knows of the Enochic tradition and has attempted to offer a different interpretation in light of John’s belief in Jesus as Israel’s Messiah.
Rotational excitation and de-excitation of magnesium mono-sulphide (MgS) by He collisions
Authors: Hendaoui Hamza , Varandas A J C , Mehnen Bilel 
Published: January 2025

ABSTRACT
Magnesium mono-sulphide (MgS) plays a crucial role in astrochemical processes, particularly in the interstellar medium (ISM), where metal-sulphur chemistry influences molecular formation and evolution. This work presents a detailed study of the rotational excitation and de-excitation of MgS through collisions with helium (He) atoms, the second most abundant species in the ISM after hydrogen, which includes both atomic (H) and molecular forms (H2). The focus on MgS–He collisions arises from He's high abundance, chemical inertness, and simpler electronic structure, which make it well suited for quantum scattering calculations. These characteristics establish He as an ideal candidate for initial studies, providing fundamental data for future investigations involving H2. The study uses quantum scattering methods to calculate the collisional rate coefficients over a broad temperature range. These rates are critical for interpreting observational data on MgS and predicting its abundance in space. The interaction potential between MgS and He is calculated using the rigid rotor approximation and the Jacobi coordinate system, employing the CCSD(T)-F12a/aug-cc-pVTZ method for accurate two-dimensional potential energy surface. The study explores the anisotropic nature of the MgS–He interaction, which favours odd Δj rotational transitions at low collision energies. The inelastic cross-sections for rotational transitions involving up to 16 rotational levels of MgS were computed up to 1000 cm−1, enabling the calculation of rate coefficients up to 150 K for Δj = ±1, ±2, and ± 3 rotational transitions. The results show that Δj = 1 transitions dominate at low temperatures, while Δj = 2 transitions become more significant at higher temperatures. This study provides valuable data for interpreting future astrophysical observations of MgS. The findings also propose new rotational transitions for MgS detection in space, enhancing our ability to track and study this molecule in various cosmic environments.
Risk factors for cytomegalovirus reactivation during the treatment of ANCA-associated vasculitis: A retrospective cohort study of the J-CANVAS study
Authors: Kawamori Kazutaka , Oguro Nao , Shimizu Kunika , Kida Takashi , Omura Satoshi , Nakagomi Daiki , Abe Yoshiyuki , Kadoya Masatoshi , Takizawa Naoho , Nomura Atsushi , Kukida Yuji , Kondo Naoya , Yamano Yasuhiko , Yanagida Takuya , Endo Koji , Hirata Shintaro , Matsui Kiyoshi , Takeuchi Tohru , Ichinose Kunihiro , Kato Masaru , Yanai Ryo , Matsuo Yusuke , Shimojima Yasuhiro , Nishioka Ryo , Okazaki Ryota , Takata Tomoaki , Ito Takafumi , Moriyama Mayuko , Takatani Ayuko , Miyawaki Yoshia , Ito-Ihara Toshiko , Kawaguchi Takashi , Kawahito Yutaka , Yajima Nobuyuki 
Published: January 2025

ABSTRACT

Objectives
Cytomegalovirus (CMV) reactivation during immunosuppressive therapy poses a risk of severe infections. This study aimed to investigate the risk factors of CMV reactivation in patients with microscopic polyangiitis and granulomatosis with polyangiitis using a nationwide cohort in Japan.

Methods
This retrospective cohort study used data from the Japan Collaborative Registry of antineutrophil cytoplasmic antibody-associated vasculitis. The outcome was as CMV reactivation up to 48 weeks after treatment initiation. We explored the risk factors for CMV reactivation by comparing the two groups.

Results
Of the 454 patients, CMV reactivation occurred in 89 (19.6%). The univariate analysis showed that patients with CMV reactivation were older (P &lt; .001), had higher Birmingham Vasculitis Activity Scores (BVAS) (P = .004) and BVAS renal scores (P &lt; .001), and had received glucocorticoid pulse (P = .004). The logistic regression analysis showed that hypoalbuminemia (odds ratio: 0.55, 95% confidence interval: 0.31–0.98), and low serum IgG (OR: 0.94, 95% CI: 0.89–1.00) were risk factors for CMV reactivation.

Conclusions
Hypoalbuminemia and low serum IgG levels were risk factors for CMV reactivation. It is necessary to accurately identify high-risk patients and closely monitor their condition.
Premovement activity in the corticospinal tract is amplified by the placebo effect: an active inference account
Authors: Emadi Andani Mehran , Braga Miriam , Da Dalt Francesco , Piedimonte Alessandro , Carlino Elisa , Fiorio Mirta 
Published: January 2025

Abstract
The aim of this study is to investigate whether expectancy, induced through a placebo procedure, favors the activation of the corticospinal tract before movement initiation. By adopting the premovement facilitation paradigm, we applied transcranial magnetic stimulation over the left or right primary motor cortex at rest and 100 ms or 50 ms before movement onset while healthy volunteers performed a reaction time (RT) motor task consisting of abductions of the right or left thumb after a go signal. Participants in the placebo group received an inert electrical device applied on the right forearm along with information on its speed-enhancing properties. A control group received the same device with overt information about its inert nature, while another control group underwent no intervention. Along with RT, we measured the amplitude of the motor evoked potential (MEP) before and after the procedure. Compared to the control groups, the placebo group had faster RT and greater MEP amplitude before movement initiation. This study demonstrates that the placebo effect can boost the activity of the corticospinal tract before movement onset, and this modulation positively impacts motor performance. These results give experimental support to the active inference account.
Association of novel EEG biomarkers of sleep depth and cortical arousability with cardiac autonomic modulation in adolescents
Authors: Rahawi Anthony H , He Fan , Fang Jidong , Calhoun Susan L , Vgontzas Alexandros N , Liao Duanping , Bixler Edward O , Younes Magdy , Ricci Anna , Fernandez-Mendoza Julio 
Published: January 2025

Abstract

Study Objectives
To examine the developmental association of the odds ratio product (ORP), an electroencephalographic measure of sleep depth, during non-rapid eye movement (NREM) sleep with 24-hour heart rate variability (HRV), an electrocardiographic measure of cardiac autonomic modulation (CAM), in the transition to adolescence.

Methods
Leveraging data from the Penn State Child Cohort, we performed longitudinal analyses on 313 children (median [Md] age 9 years) followed-up after Md = 7.4y and cross-sectional analyses on 344 adolescents (Md = 16 years). We extracted ORP during NREM sleep and in the 9 seconds following cortical arousals (ORP-9) from 9-hour, in-lab polysomnography, and frequency- and time-domain HRV indices from 24-hour Holter ECG monitoring. Longitudinal and cross-sectional, multivariable-adjusted, regression models examined the association between ORP and ORP-9 with adolescent 24-hour HRV indices.

Results
Longitudinally, a greater increase in ORP-9 since childhood was associated with lower daytime Log-LF, SDNN, RMSSD, and higher HR in adolescence (p &lt; .05). A greater increase in ORP since childhood was associated with lower nighttime Log-LF and SDNN (p &lt; .05). Cross-sectionally, higher ORP and ORP-9 were associated with lower daytime and nighttime Log-LF, SDNN or RMSSD and higher HR within adolescence (p &lt; .05).

Conclusions
A greater increase in cortical arousability since childhood is a strong developmental predictor of daytime cardiac autonomic imbalance in adolescence. Shallower sleep depth additionally arises as a proximal determinant of both daytime and nighttime cardiac autonomic imbalance within adolescence. These data suggest a coupling between fine-grained spectral measures of the sleeping brain and those of CAM, which may inform sleep-related cardiovascular risk early in life.
Can malaria be eliminated? 15 years on
Authors: Liu Youjia , Richardson Sol 
Published: January 2025

Abstract
This commentary reflects on the ongoing challenges and strategies in malaria elimination, built on insights from Greenwood's 2009 commentary, alongside more recent publications and developments up to 2024. Many of the challenges and strategies discussed by Greenwood remain relevant today. Furthermore, several of Greenwood's predictions have proven accurate 15 years on. Despite significant global progress, malaria elimination faces its toughest challenge, particularly in high-transmission areas. As we confront tougher challenges in malaria elimination, it becomes clear that we must go beyond mere reliance on any single solution.
Mamastrovirus species are shaped by recombination and can be reliably distinguished in ORF1b genome region
Authors: Aleshina Yulia , Lukashev Alexander 
Published: January 2025

Abstract
Astroviruses are a diverse group of small non-enveloped positive sense single-stranded RNA viruses that infect animals and birds. More than half of all known genome sequences of mammalian astroviruses are not assigned to provisional species, and the biological mechanisms that could support segregation of astroviruses into species are not well understood. The systematic analysis of recombination in Mamastrovirus genomes available in GenBank was done to identify mechanisms providing genetic distinction between astroviruses. Recombination breakpoints were present in all Mamastrovirus genome regions, but occurred most commonly at the ORF1b/ORF2 junction. Recombination was ubiquitous within, but never between established and putative new species, and may be suggested as an additional species criterion. The current species criterion for the genus Mamastrovirus based on ORF2 amino acid sequence p-distances did not reliably distinguish several established species and was of limited use to identify distinct groups among unclassified astroviruses that were isolated recently, predominantly from cattle and pigs. A 17% nucleotide sequence distance cut-off in ORF1b fairly distinguished the established species and several groups among the unclassified viruses, providing better correspondence between phylogenetic grouping, reproductive isolation and the virus hosts. Sequence distance criteria (17% in nucleotide sequence of ORF1b and 25% in amino acid sequence of ORF2) and the recombination pattern corresponded fairly well as species criteria, but all had minor exclusions among mammalian astroviruses. A combination of these taxonomic criteria supported the established Mamastrovirus species and suggested redefining a few provisional species that were proposed earlier and introducing at least six novel species among recently submitted rat and bovine astroviruses.
Association between obesity and Bell’s palsy by combining Mendelian randomization and network pharmacology
Authors: Zhong Li , Jiang Wei , Liu Yan , Huang Juan 
Published: January 2025

Background:
The issue of obesity has emerged as a significant global health challenge; nevertheless, the association between Bell’s palsy (BP) and obesity remains ambiguous. In this study, the Mendelian randomization (MR) approach was employed to investigate their relationship, while network pharmacology methods were utilized to unveil the underlying mechanisms.

Methods:
We utilized single nucleotide polymorphisms closely linked to obesity and BP as instrumental variables for the MR analysis. Four robust bidirectional MR analysis methods, namely inverse variance weighting (IVW), weighted median, weighted mode, and MR-Egger were employed to assess the association between obesity and BP. Additionally, sensitivity analysis was conducted to evaluate levels of heterogeneity, sensitivity, and stability. Furthermore, we identified therapeutic targets associated with obesity and BP. Subsequently, a protein–protein interaction network analysis was conducted. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were employed to investigate potential mechanisms underlying the relationship between obesity and BP.

Results:
The IVW analysis demonstrated a significant positive correlation between obesity and BP (odds ratio [OR] = 1.267, 95% confidence interval [95% CI] = 1.049–1.530, P = .013). However, there was no evidence to suggest that BP increased the risk of obesity. Furthermore, network pharmacology analysis revealed that the 2 diseases shared a total of 712 common targets. GO enrichment analysis shows that this process mainly regulates chemical synaptic signal transmission by modulating receptor signaling factor activity, receptor ligand activity, etc. KEGG enrichment analysis shows that the EGFR/PI3K/Akt signaling pathway plays a significant role in this process.

Conclusion:
Our study findings suggest that obesity may increase the risk of BP, and its underlying mechanism may potentially involve regulating chemical synaptic transmission through the EFGR/PI3K/Akt signaling pathway.
Schwannoma in the lower inner quadrant of the right breast in a male patient: A rare case report
Authors: Chen Jingjing , Huang Yan , Liu Haofeng , Sun Yuanyuan , Liu Fufeng 
Published: January 2025

Rationale:
Lower inner-quadrant breast schwannomas are exceedingly rare, with no reports of their occurrence in male patients in the literature. In this report, we describe a male patient with a schwannoma in the lower inner quadrant of the right breast.

Patient concerns:
A 26-year-old man presented at our hospital with a 6-month history of a lump in the right breast and reported pain in the area 3 days prior to presentation. Ultrasonography identified a 0.86 × 0.64 cm hypoechoic nodule 0.41 cm beneath the skin in the lower inner quadrant of the right breast. The nodule exhibited clear boundaries and uniform internal echogenicity with no signs of significant blood flow on color Doppler flow imaging. The patient was concerned that the nodule was benign or malignant.

Diagnoses:
Histopathological and immunohistochemical analyses after complete surgical excision confirmed that the lesion was breast schwannoma. The postoperative course was unremarkable and the tumor did not recur during 7 years of follow-up.

Interventions:
Biochemical parameters were examined preoperatively. The radiological examination of breast color Doppler ultrasound was performed.

Outcomes:
A well-shaped, 0.86 × 0.64 cm mass, complete capsule in the lower inner quadrant of the right breast was surgically resected. The postoperative course was unremarkable and the tumor did not recur during 7 years of follow-up.

Lessons:
Breast schwannoma is an extremely rare tumor that is very difficult to preoperatively diagnose. Preoperative biochemical examination and ultrasonography can only provide diagnostic ideas. Histological and immunohistochemical analyses are required for confirmation. It can transform into malignant peripheral nerve sheath tumors, but not often. Consequently, regular postoperative follow-up is required for such patients, especially ultrasonography.
High-dose methotrexate-based chemotherapy for induction remission of newly diagnosed primary CNS lymphoma: A systematic review and meta-analysis
Authors: Shi Han , Sun Xuefei , Wu Yuchen , Cui Qu , Sun Shengjun , Ji Nan , Liu Yuanbo 
Published: January 2025

Background:
This study aimed to comprehensively assess the optimal regimen for high-dose methotrexate (HD-MTX) in treating primary central nervous system lymphoma (PCNSL).

Methods:
We have searched 8 databases, including PubMed, EMBASE, Cochrane Library, WOS, Epistemonikos, CNKI, WAN-FANG Database, and CBM, and were selected for the clinical trials about PCNSL. A total of 37 studies were included in our analysis, consisting of 6 randomized controlled trials and 31 single-arm clinical studies.

Results:
After analyzing the data from 37 clinical studies, we found that the pooled overall response rate (ORR) for low-dose (<3 g/m2), medium-dose (3–5 g/m2), and high-dose (>5 g/m2) methotrexate (MTX) were 0.78, 0.80, and 0.80, respectively. The pooled 2-year overall survival (OS) for low-dose, medium-dose, and high-dose MTX were 52%, 60%, and 71%, respectively. The ORR, complete response (CR), and 2-year OS of patients who received <5 cycles of MTX were 79%, 41%, and 59%, respectively, whereas those for PCNSL patients who received >5 cycles of MTX were 81%, 54%, and 64%, respectively. The pooled ORR for MTX, dual therapy, triplet therapy, tetrad therapy, and multiple therapy were 71%, 70%, 81%, 85%, and 80%, respectively. The pooled 2-year OS for different numbers of medication combinations were 59%, 52%, 66%, 63%, and 60%, respectively. The addition of cytarabine to MTX-based chemotherapy resulted in higher CR, although no statistically significant difference was observed in OS. Adding rituximab to the treatment regimen improved patients’ progression-free survival without affecting treatment response or OS.

Conclusion:
Based on the findings of this study, the treatment strategies of MTX are associated with the prognosis and efficacy response of PCNSL patients. The results suggested that the current recommended HD-MTX dosage of 3.5 g/m2 is sufficient for PCNSL to have a favorable treatment response and prognosis. When the number of MTX treatment cycles increases, the therapeutic effect and prognosis of PCNSL patients are improved. The patients treated with MTX-based triplet combination regimens have a better ORR and CR. Although HD-MTX is generally well tolerated, it is necessary to be cautious about the use of multiple therapy that includes cytarabine to prevent potential acute toxicity.
Kidney and pregnancy outcomes in pregnancy-associated atypical hemolytic uremic syndrome: A systematic review and meta-analysis
Authors: Meena Priti , Gala Ruju , Das Rashmi Ranjan , Bhargava Vinant , Saivani Yellampalli , Panda Sandip , Mantri Alok , Agrawaal Krishna Kumar 
Published: January 2025

Background:
Pregnancy-associated atypical hemolytic uremic syndrome (p-aHUS) is a rare, life-threatening condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, elevated liver enzymes, and acute kidney injury. Prompt diagnosis and therapy are crucial due to the high risk of progression to chronic kidney disease (CKD), end-stage kidney disease (ESKD), and dialysis dependency, as well as significant maternal and fetal morbidity and mortality.

Methods:
A comprehensive literature search was conducted across EMBASE, MEDLINE, and the Cochrane CENTRAL from January 2000 to March 2024. Studies reporting on pregnancy and kidney outcomes in women diagnosed with p-aHUS were included.

Results:
Ten studies involving 386 pregnancies in 380 patients met the inclusion criteria for the final analysis. Renal outcomes varied, with mean creatinine levels ranging from 0.72 to 8.734 mg/dL. Dialysis was required in 66.6% of patients, and 25% developed ESKD. Maternal complications included preeclampsia (36.4%) and hemolysis, elevated liver enzymes, and low platelets syndrome (29.7%), with a 5% maternal mortality rate. Fetal complications included intrauterine fetal demise (n = 25), intrauterine growth restriction, low birth weight, and prematurity. Treatment with eculizumab significantly reduced the risk of CKD and ESKD, with a pooled risk ratio of 0.20 (95% confidence interval: 0.09–0.44) and low heterogeneity (I² = 0%, P = .43).

Conclusion:
This analysis highlights the severe kidney and pregnancy outcomes associated with p-aHUS. Eculizumab treatment is significantly beneficial in reducing the risk of CKD and ESKD.