bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phân tích thực trạng sử dụng thuốc kháng sinh tại Khoa Nội - Bệnh viện Kiến An Hải Phòng năm 2019
Authors: Nguyễn Văn Quân , Nguyễn Thị Thủy 
Published: October 2023

Kháng sinh luôn được sử dụng trong các bệnh viện để điều trị nhiễm khuẩn.
Bằng các phương pháp nghiên cứu: hồi cứu mô tả và phân tích chi phí đề tài đã nghiên cứu thực trạng sử dụng và chi phí sử dụng thuốc kháng sinh tại khoa Nội Bệnh viện Kiến An - Hải Phòng năm 2019.
Kết quả nghiên cứu thu được từ 384 bệnh án: Nhiễm khuẩn nằm trong 12 mã bệnh ICD-10 phân bố trong 5 nhóm bệnh; Tỷ lệ ghi đầy đủ họ tên, tuổi, giới tính, địa chỉ của bệnh nhân đạt 98.4%; Tỷ lệ ghi đầy đủ tiền sử bệnh chiếm 97.1%, tiền sử dùng thuốc chiếm 95.8 và tiền sử dị ứng chiếm 96.4%. Tỷ lệ ghi đầy đủ chẩn đoán bệnh không viết tắt hay viết ký hiệu chiếm 82.3%; Tỷ lệ bệnh án được làm kháng sinh đồ chiếm 84,7%. Bệnh lý mắc kèm có thể là 0, 1,2,3 bệnh; có 26 hoạt chất kháng sinh được sử dụng theo tỷ lệ từ 0,03 – 40,0%. Có 6 nhóm kháng sinh được sử dụng trong đó nhóm beta – lactam chiếm 66,2% về lượng và 77% về giá trị. Thời gian sử dụng kháng sinh trung bình của bệnh nhân tại khoa Nội là 7,7 ± 2,8 ngày; thời gian nằm viện trung bình là 7,7 ± 2,8 ngày; số bệnh án sử dụng 1 phác đồ kháng sinh chiếm tỷ lệ cao nhất với 89,3%; Số BA có kết quả điều trị của bệnh nhân là khỏi chiếm tới 77,3%, chi phí kháng sinh/Chi phí thuốc: 0.52 và Chi phí kháng sinh/Chi phí điều trị: 0.23.
Nghiên cứu tác dụng chống viêm loét dạ dày - tá tràng của bài thuốc “Kiện tỳ chỉ thống HV” trên thực nghiệm
Authors: Nguyễn Thanh Trung , Phạm Quốc Bình , Phạm Thị Vân Anh , Đinh Thị Thu Hằng 
Published: October 2023

Mục tiêu: Đánh giá tác dụng của bài thuốc “Kiện tỳ chỉ thống HV” (KTHV) trên chuột cống bị gây viêm loét dạ dày - tá tràng do indomethacin.
Đối tượng và phương pháp: Chuột cống trắng được chia thành 5 lô: Lô 1 (chứng sinh học) và lô 2 (mô hình); lô 3 (misoprostol 50 μg/kg), lô 4 (KTHV liều 15 g/kg) và lô 5 (KTHV liều 30 g/kg). Chuột ở các lô được uống nước cất, thuốc và mẫu thử liên tục trong thời gian 7 ngày. Vào ngày thứ 7, chuột được uống indomethacin liều 40 mg/kg. Sau 6 giờ, tiến hành đánh giá tỷ lệ chuột có viêm loét dạ dày-tá tràng, chỉ số loét, khả năng ức chế loét và hình ảnh đại thể và vi thể của các lô.
Kết quả: Indomethacin gây loét dạ dày tá tràng ở 100% trên chuột lô mô hình. KTHV cả 2 mức liều làm giảm số ổ loét, chỉ số loét, tăng khả năng ức chế loét và trên hình ảnh đại thể và vi thể cho thấy tổn thương trên dạ dày, tá tràng nhẹ hơn so với lô mô hình.
Nghiên cứu ảnh hưởng của viên nang Đông trùng hạ thảo Banikha lên chức năng gan, thận chuột cống thực nghiệm
Authors: Phạm Thị Vân Anh , Đinh Thị Thu Hằng , Nguyễn Thị Hồng Gấm , Nguyễn Thị Hồng , Nguyễn Thị Thương , Lê Minh Sắt , Nguyễn Duy Thuần 
Published: October 2023

Mục tiêu: Đánh giá ảnh hưởng của viên nang Đông trùng hạ thảo Banikha theo đường uống lên chức năng gan, thận chuột cống thực nghiệm.
Phương pháp nghiên cứu: Chuột cống trắng được uống liên tục viên nang Đông trùng hạ thảo Banikha với mức liều 0,39 g/kg/ngày và 1,16 g/kg/ngày trong vòng 4 tuần. Trước lúc uống thuốc, sau 2 tuần và 4 tuần uống thuốc, chuột được đánh giá chức năng gan và chức năng thận. Giải phẫu bệnh gan, thận được đánh giá khi kết thúc nghiên cứu ở tuần thứ 4.
Kết quả và bàn luận: Kết quả nghiên cứu cho thấy viên nang Đông trùng hạ thảo Banikha liều 0,39 g/kg/ ngày và 1,16 g/kg/ngày dùng đường uống liên tục trong 4 tuần không ảnh hưởng đến hoạt độ AST, hoạt độ ALT, nồng độ bilirubin toàn phần, cholesterol toàn phần, albumin, creatinin trong máu và hình ảnh mô bệnh học gan, thận trên chuột cống trắng ở cả 2 mức liều.
Đánh giá hiệu quả cai nghiện thuốc lá của phương pháp nhĩ áp tại Bệnh viện Y học cổ truyền Trung ương năm 2020
Authors: Trần Thái Hà , Phạm Hồng Ngọc 
Published: October 2023

Mục tiêu nghiên cứu: Đánh giá tác dụng điều trị cai nghiện thuốc lá của phương pháp nhĩ áp, theo dõi tác dụng không mong muốn trên một số chỉ số lâm sàng.
Đối tượng và phương pháp nghiên cứu: Phương pháp thử nghiệm lâm sàng so sánh trước sau điều trị liệu trình 28 ngày. Đối tượng là 30 bệnh nhân tới điều trị cai nghiện thuốc lá tại Bệnh viện Y học cổ truyền Trung ương từ tháng 6 đến tháng 9 năm 2020.
Kết quả: Sau 28 ngày điều trị, Cai thuốc lá đạt tỷ lệ tốt là 46.7%, khá là 20% và 33.3% không kết quả.
Kết luận: Phương pháp nhĩ áp có tác dụng làm giảm lượng CO trong máu của bệnh nhân và cải thiện các triệu chứng của hội chứng cai (thèm thuốc, cáu gắt, giảm tập trung, mất ngủ...).
FEATURES OF THE IMPLEMENTATION OF INTERACTIVE AND PRACTICAL TEACHING METHODS IN EDUCATIONAL INSTITUTIONS OF HIGHER EDUCATION OF OF EMERCOM OF RUSSIA
Authors: Golovenko Vladislav , Mikhailov Valery , Mikhailova Valentina 
Published: October 2023

The importance of the introduction of interactive and practical methods of training employees of the Ministry of Emergency Situations of Russia is substantiated, the justification of the spatio-temporal statistical analysis of activities on simulators carried out on the basis of taking into account
the frequency, difficulty and responsibility of individual actions is given. The analysis of innovative technologies for working with future officers, content elements, methods of using interactive and practical training tools, justification of psychological and pedagogical conditions for its implementation is presented. It is shown that the strongest motive for the development of a fire-technical specialty by cadets is an interest in the profession, contributing to the development of self-awareness. The introduction of information and didactic training systems based on computer technologies, in particular, simulators operating on the principle of controlled virtual simulation, is justified.
WAYS TO IMPROVE MATHEMATICAL EDUCATION IN UNIVERSITIES OF EMERCOM OF RUSSIA
Authors: Trophimets Elena 
Published: October 2023

Substantiates the expediency of using the MS Excel spreadsheet processor and the Mathcad mathematical package to solve research problems. The theoretical foundations of the statistical testing method are presented. The applied aspects of the application of the statistical test method are considered.
The ways of improving the teaching of mathematical cycle disciplines in the conditions of digitalization
of education are determined.
ENVIRONMENTAL SAFETY IN THE RUSSIAN ARCTIC: PROPER LEGAL INSTRUMENTS
Authors: Nikishin Vladislav 
Published: October 2023

The article reveals the terminological content of the concept of «environmental safety».
It is argued that environmental safety in the Arctic can and should be ensured by a system that includes legal, economic, technological and other measures applied in the present and future times. Taking into account the declared features of the Arctic zone of the Russian Federation, special approaches to legal assurance of environmental safety are determined. The use of a software approach in the field of environmental protection and environmental management in the Arctic is being analyzed. It is proposed to adopt a special law «On environmental protection of the Arctic zone of the Russian Federation», taking into account the features of vulnerable arctic ecosystems.
Collaboration before Writing: Exploring How Student Talk Contributes to English L2 Written Narratives
Authors: McDonough Kim , Hernández González Teresa 
Published: October 2023

Previous studies of prewriting discussions have focused narrowly on classifying the type of student talk e.g., content, organization, language) that occurred during a short planning period. However, less is known about how students’ interactions unfold across multiple prewriting discussions in an entire lesson. To gain further insight into the relationship between collaborative talk and individual writing, this case study explores how two ESL students, Lendina and Mateo, interact during three prewriting activities in one lesson. Data sources include transcripts of the students’ discussions, their narrative texts, and perceptions from the students, their teacher, and an observer. Findings revealed that their discussions were characterized by collaboration (e.g., equality, mutuality, and shared epistemic stance), with each activity contributing concepts and lexical expressions to the students’ narratives. Implications for instructors interested in integrating prewriting discussions into their classes are provided.
Formulasi Sistem Pembuktian Terbalik Tindak Pidana Korupsi di Indonesia dalam Perspektif Hukum Islam
Authors: S Suaidi 
Published: October 2023

Corruption have widespread and even became a culture of Indonesia that the government set up a new system, known as Reversal Burden Of Proof. Even though the model is considered to be contrary to the fundamental principle of the rule of law, but in Islamic law and the evidence, it is legally seen as a necessity to eradicating corruption. It is based on the demands and the welfare of Reversal Burden Of Proof Formulation.
Konsep Pernikahan dalam Al-Quran
Authors: Athar Mohamad 
Published: October 2023

Ada beberapa definisi nikah yang dikemukakan ulama fiqh, tetapi seluruh definisi tersebut mengandung esensi yang sama meskipun redaksionalnya berbeda. Ulama Mazhab Syafi’i mendefinisikannya dengan “akad yang mengandung kebolehan melakukan hubungan suami istri dengan lafaz nikah atau kawin atau yang semakna dengan itu”. Sedangkan ulama Mazhab Hanafi mendefinisikannya dengan “akad yang memfaedahkan kehalalannyauntuk melakukan hubungan suami istri antara seorang laki-laki dan seorang perempuan selama tidak ada halangan syara’.
The Breastfeeding with Nutritional Status Based on Toddler’s Height in Bondowoso
Authors: Prabawati Candrika Eka , J Jamhariyah , Bachri Syaiful 
Published: October 2023

Introduction: The incidence of stunting in toddler in Indonesia has been above the WHO target. In Bondowoso, the prevalence of stunting in February 2019 reached 17.54% of 45,002 toddlers. Stunting is closely related to inadequate nutrition, one of which is exclusive breastfeeding. The purpose of research was to determine the relationship of breastfeeding with nutritional status based on toddler’s height in Walidono Village, Prajekan District, Bondowoso Regency.
Methode: The type of research was a correlational study with a case control approach. Total population of 46 toddlers aged 24-36 months and obtained a sample of 41 toddlers with proportional random sampling technique. The instrument used questionnaires giving ASI, microtoise and z score application. Data analysis used Chi Square test and obtained the Contingency Coefficient value with the help of the SPSS 26.
Results: The results shows 51.22% of toddlers with no history of exclusive breastfeeding and 48.78% were given exclusive breastfeeding, toddler stunting 43.90% and not stunting 56.10%. The analysis results obtain p-value of 0.039 <α (0.05), it can be concluded that H0 is rejected Ha is accepted, with a Contingency Coefficient value of 0.306 meaning that there is a relationship between breastfeeding and nutritional status based on toddler’s height in Walidono Village, Prajekan District, Bondowoso Regency.
Conclusion: Midwives are expected will increase the provision of information on exclusive breastfeeding to pregnant and breastfeeding mother in order to prevent stunting in toddler.
Effects of mental rotation on map representation in orienteers—behavioral and fNIRS evidence
Authors: Zhao Mingsheng , Liu Jingru , Liu Yang , Kang Pengyang 
Published: October 2023

Objective
Taking orienteering as an example, this study aimed to reveal the effects of mental rotation on orienteers’ map representation and their brain processing characteristics.

Methods
Functional near-infrared spectroscopic imaging (fNIRS) was used to explore the behavioral performance and cortical oxyhemoglobin concentration changes of map-represented cognitive processing in orienteering athletes under two task conditions: normal and rotational orientation.

Results
Compared to that in the normal orientation, athletes’ task performance in the rotated orientation condition was significantly decreased, as evidenced by a decrease in correct rate and an increase in reaction time; in the normal orientation condition, blood oxygen activation in the dorsolateral prefrontal lobe was significantly greater than that in the ventral prefrontal lobe, which was significantly correlated with the correct rate. With rotating orientation, the brain oxygen average of each region of interest was enhanced, and the brain region specifically processed was the ventral prefrontal lobe, specifically correlating with the correct rate.

Conclusions
Mental rotation constrains the map representation ability of athletes, and map representation in rotational orientation requires more functional brain activity for information processing. Ventral lateral prefrontal lobe activation plays an important role in the map representation task in rotational orientation.
SolderNet: Towards trustworthy visual inspection of solder joints in electronics manufacturing using explainable artificial intelligence
Authors: Gunraj Hayden , Guerrier Paul , Fernandez Sheldon , Wong Alexander 
Published: October 2023

AbstractIn electronics manufacturing, solder joint defects are a common problem affecting a variety of printed circuit board components. To identify and correct solder joint defects, the solder joints on a circuit board are typically inspected manually by trained human inspectors, which is a very time‐consuming and error‐prone process. To improve both inspection efficiency and accuracy, in this work, we describe an explainable deep learning‐based visual quality inspection system tailored for visual inspection of solder joints in electronics manufacturing environments. At the core of this system is an explainable solder joint defect identification system called SolderNet that we design and implement with trust and transparency in mind. While several challenges remain before the full system can be developed and deployed, this study presents important progress towards trustworthy visual inspection of solder joints in electronics manufacturing.
Silver Nanowire Reinforced Conductive and Injectable Colloidal Gel for Effective Wound Healing Via Electrical Stimulation
Authors: Du Yaxin , Yan Xu , Chen Sheng , Zha Zhengbao , Wu Wenshu , Song Yonghong , Wu Yadong , Li Kangkang , Liu Xingyu , Lu Yang 
Published: October 2023

AbstractThe remarkable biocapacity, injectability, and adaptability of colloidal gels lead to their widespread use in tissue engineering as irregular defect implants. However, multifunctionalities including electroconductivity and antibacterial property are highly required for colloidal gels. In addition, the inherently weak mechanical property of physically crosslinked colloidal gels limits their application. Herein, Ag nanowires (Ag NWs)‐reinforced colloidal gels composed of biocompatible gelatin nanoparticles and polydopamine‐modified Ag NWs through the controlled electrostatic assembly, which are injectable and conductive, are presented. 1D Ag NWs can significantly improve the mechanical and electrical properties of the colloidal gel while maintaining its inherent excellent injectability. Owing to the network of Ag NWs, the storage modulus and conductivity of the optimized Ag NW colloidal gel are 7.5 and 13 times higher, respectively, than those of the colloidal gel made up of polydopamine‐modified Ag nanoparticles with equivalent Ag concentration. Further, this Ag NW colloidal gel can adapt to sharp wounds on skin, which accelerates the healing of an MRSA‐infected wound via electrical stimulation.
Macrophage Membrane‐Camouflaged Aggregation‐Induced Emission Nanoparticles Enhance Photodynamic‐Immunotherapy to Delay Postoperative Tumor Recurrence
Authors: Meng Zijuan , Wang Tingting , Hu Yuxin , Ouyang Hanzhi , Wang Quan , Wu Meng , Zhou Jian , Lou Xiaoding , Wang Shixuan , Dai Jun , Xia Fan 
Published: October 2023

AbstractSurgery is a traditional tumor treatment, and immunotherapy can reduce the postoperative recurrence of tumors. However, the intrinsic limits of low responsive rate and non‐tumor specificity of immunotherapy agents are still insufficient to address therapeutic demands. Herein, the macrophages membrane camouflaged nanoparticles (NPs), named M@PFC, consisting of the aggregation‐induced emission photosensitizer (PF3‐PPh3) and immune adjuvant (CpG), are reported. As the protein on the membrane interacts with the vascular cell adhesion molecule 1 (VCAM‐1) of cancer cells, M@PFC efficiently transports CpG to the tumor. Meanwhile, M@PFC can evade clearance by the immune system and prolong the circulation time in vivo; thus, enhancing their accumulation in tumors. PF3‐PPh3 promotes high production of reactive oxygen species (ROS) and triggers immune cell death (ICD) in tumor cells under light exposure. Importantly, CpG enrichment in tumors can stimulate tumor cells to produce immune factors to assist in enhancing ICD effects. The synergistic effect combining the PDT properties of the aggregation‐induced emission (AIE)‐active photosensitizer and immunotherapy properties of CpG significantly delays tumor recurrence after surgery. In conclusion, this strategy achieves the synergistic activation of the immune system for anti‐tumor activity, providing a novel paradigm for the development of therapeutic nanodrugs to delay postoperative tumor recurrence.
A chiral spirofluorene‐embedded multiple‐resonance thermally activated delayed fluorescence emitter for efficient pure‐green circularly polarized electroluminescence
Authors: Luo Xu‐Feng , Song Shi‐Quan , Wu Xueying , Yip Ching‐Fai , Cai Songliang , Zheng You‐Xuan 
Published: October 2023

AbstractThe simultaneous achievement of chiral multiple‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters with narrowband and circularly polarized electroluminescence (CPEL) poses a challenge. Herein, a MR‐TADF emitter, Spiro‐BNCz, embedding spirofluorene structure was developed and chiral separated, whose emission peaks at 528 nm in toluene with Commission Internationale de L'Eclairage coordinates of (0.26, 0.69). The conjugation extension caused by embedding sulfur substituted spirofluorene on B/N framework shortens the singlet‐triplet energy gap and increases spin‐orbital coupling matrix element. Therefore, a fast reverse intersystem crossing rate constant of 2.8 × 106 s−1 and a high photoluminescence efficiency of 92% in film were achieved. The organic light‐emitting diode (OLED) exhibits a maximum external quantum efficiency of 32.3%. Particularly, the circularly polarized OLEDs based on Spiro‐BNCz enantiomers show symmetric CPEL with dissymmetry factors (|gEL|) ≈ 10−3.
Future–present relationship insensitivity: A new perspective on psychological myopia and psychological hyperopia
Authors: Wei Sarah , Hsee Christopher K. 
Published: October 2023

AbstractHow much joy versus pain people choose to experience for the present often inversely affects how much joy versus pain they will experience in the future. Do people make choices that maximize their overall happiness? Prior research suggests that people are generally myopic (i.e., over‐choosing joy for the present). We suggest that the prior research may have biasedly focused only on situations in which the future is more important than the present. Rather, people are generally insufficiently sensitive to the relative importance of the present versus the future. When the future is more important than the present, people over‐choose joy for the present, thus appearing myopic, but when the future is less important than the present, people under‐choose joy for the present, thus appearing hyperopic. Six experiments (along with a reason‐exploration study) demonstrate our propositions and show that forcing or nudging people to choose less (more) joy for the present when the future is more (less) important increases their overall happiness. This research challenges the popular view that people are generally myopic, and supports emerging research showing that people are generally situation‐insensitive and can exhibit seemingly opposite biases (e.g., myopia and hyperopia) in different situations.
Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer
Authors: Song Yue , Bai Guiying , Li Xiaoqing , Zhou Liyan , Si Yiran , Liu Xiaohui , Deng Yilin , Shi Yehui 
Published: October 2023

AbstractBackgroundMetaplastic breast carcinoma (MBC) is a rare breast cancer subtype; most cases are triple‐negative breast cancers (TNBCs) and are poorly responsive to conventional systemic therapy. Few potential diagnostic and prognostic markers for distinguishing between metaplastic TNBC and nonmetaplastic TNBC have been discovered. We performed bioinformatic analysis to explore the underlying mechanism by which metaplastic TNBC differs from nonmetaplastic TNBC and provides potential pathogenic genes of metaplastic TNBC.MethodsDifferentially expressed genes (DEGs) in metaplastic tumors and nonmetaplastic tumors from TNBC patients were screened using GSE165407. The GSE76275 data set and The Cancer Genome Atlas (TCGA) database were used to screen DEGs in TNBC and non‐TNBC. Metascape and DAVID were used for the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and Gene Ontology (GO) analysis of DEGs. Online databases, including UALCAN, GEPIA, HPA, Breast Cancer Gene‐Expression Miner, and quantitative PCR and western blot, were used to examine KLK5 messenger RNA and protein expression in breast cancer. Analysis of KLK5‑associated genes was performed with TCGA data, and the LinkedOmics database was used to detect the genes co‐expressed with KLK5. STRING (Search Tool for the Retrieval of Interacting Genes) and Cytoscape were used to screen for hub genes. Kaplan‑Meier plotter was used for survival analysis.ResultsKLK5 was identified among the DEGs in nonmetaplastic TNBC and metaplastic TNBC. The KLK5 gene was overexpressed in nonmetaplastic TNBC but downregulated in metaplastic TNBC. KEGG and GO analyses revealed that epithelial‐to‐mesenchymal transition was a pathogenic mechanism in metaplastic TNBC and an important pathway by which KLK5 and its associated genes DSG1 and DSG3 influence metaplastic TNBC progression. Prognosis analysis showed that only low expression of KLK5 in metaplastic TNBC had clinical significance.ConclusionOur research indicated that KLK5 may be a pivotal molecule with a key role in the mechanism of tumorigenesis in metaplastic TNBC.
Consequence of head‐on collision and double‐layer soliton with linear analysis in multi‐component dusty plasmas
Authors: Imon Umma , Alam M. S. 
Published: October 2023

AbstractThe unmagnetized multicomponent collisional dusty plasmas have been considered to investigate the consequence of head‐on collision of dust‐ion‐acoustic waves (DIAWs) with nonlinear characteristic analysis of DIAWs and collisionless plasmas have been considered for studying the production of double layer (DL). The plasma system consists of positively charged ion fluid, negatively charged cold dust fluid, thermal electrons, q‐nonextensive electrons, and immobile background neutral particles. The extended Poincaré‐Lighthill‐Kuo (ePLK) method has been used to derive two‐sided damped Korteweg–De Vries (dKdV) equations and the reductive perturbation method has been used to derive modified KdV (mKdV) equation and the standard Gardner equation (SGE). Linear dispersion relation is derived using linear perturbation technique. The nonlinear propagation of DIA Gardner solitons (DIAGSs) and double layers (DLs) as well as phase shifts have been investigated for the effects of the concerned parameters. It is found that the DIA soliton structures are significantly modified by the species densities, dust mass, and superextensive parameter. The rarefactive dip shape solitary Gardner solitons become produced for the effects of concerned parameters and the positive (negative) DLs become produced in the range of () for the effect of temperatures on the species. The superextensive and the subextensive parameters of electrons significantly affect the DL soliton structures.