bluuebunny/crossref_metadata_2025_split huggingface dataset:
The co-development and evaluation of an e-learning course on spinal cord injury physical activity counselling: a randomized controlled trial
Authors: Hoekstra Femke , Gainforth Heather L. , Broeksteeg Rogier , Corras Stephanie , Collins Delaney , Eleftheriadou Electra , Gaudet Sonja , Giroux Emily E. , Kuipers Laura S. , McCallum Shannon , Ma Jasmin K. , Passillé Erica , Rakiecki Diane , Rockall Shannon , Berg-Emons Rita , Vilsteren Anniek , Williamson Megan , Wilroy Jereme , Ginis Kathleen A. Martin 
Published: November 2023

Abstract
Background
Health, fitness and lifestyle professionals can play important roles in promoting physical activity in groups at risk of developing an inactive lifestyle, such as people with spinal cord injury (SCI). Tailored counselling is a promising tool to promote and improve physical activity levels. To support professionals to effectively have a conversation about physical activity with clients with SCI, evidence-based training and resources are needed. This project aimed to 1) co-develop an e-learning course on best practices for SCI physical activity counselling and, 2) examine the effectiveness and usability of this course.
Methods
Guided by the technology-enhanced learning (TEL) evaluation framework, we used a systematic, multistep approach to co-develop and evaluate an e-learning course. The development process was informed by input and feedback from a diverse group of end-users and experts (n > 160) via online surveys and (think-aloud) interviews. A randomized controlled trial was used to compare learning outcomes (post-knowledge and self-efficacy) between participants who completed the course (intervention group) and the wait-listed control group. Usability, learning experiences, and satisfaction were assessed among all participants.
Results
Forty-one participants (21 intervention-group; 20 control-group) with various backgrounds (e.g., lifestyle counsellors, physiotherapists, occupational therapists, recreation therapists, fitness trainers) enrolled in the randomized controlled trial. After completing the course, participants in the intervention group showed significantly improved knowledge on the best practices for SCI physical activity counselling and higher self-efficacy for using these best practices in conversations with clients with SCI compared to the control group (p < .001). Participants reported above average usability scores, positive learning experiences, and high levels of satisfaction when completing the course.
Conclusion
We used a systematic, multi-step, theory-informed approach to co-develop and evaluate an evidence-based e-learning course on SCI physical activity counselling to support professionals to promote physical activity in their daily practices. The overall positive findings demonstrate that the e-learning course is feasible and ready for further implementation in various health and community settings. Implementation of the e-learning course can help professionals improve the physical activity support they provide to their clients, and subsequently increase physical activity participation in people with SCI.
Association between increased Systemic Immune-Inflammation Index and postoperative delirium in older intertrochanteric fracture patients
Authors: Yan Xiaoxiao , Huang Jin , Chen Xiachan , Lin Mian 
Published: November 2023

Abstract
Background and Purpose
Systemic immune-inflammation index (SII), a novel inflammation index derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident acute cancer and ischemic stroke (AIS). However, the clinical value of SII in postoperative delirium patients had not been further investigated. The purpose of our research was to study the incidence and preoperative risk factors for postoperative delirium (POD) and verify whether SII could serve as a potential marker for POD in older intertrochanteric fracture patients. Finally, we create a novel nomogram for predicting POD patients with older intertrochanteric fracture.
Methods
We enrolled elderly patients with intertrochanteric fracture who underwent proximal femoral nail anti-rotation(PFNA)between February 2021 to April 2023. Uni variate and multivariate logistic analyses were performed to confirm the risk factors and then construct a nomogram model. The calibration curve and clinical decision curve analysis (DCA) were used to assess the model’s fitting performance. The performance of the nomogram was evaluated for discrimination, calibration, and clinical utility.
Results
293 patients were eligible for inclusion in the study, 25.6% (75/293) of patients had POD. The POD patients had higher SII levels than the non-POD group. SII is the stronger correlator for POD in older intertrochanteric fracture patients, of which the optimal cut-off value was 752.6×109. Multivariate analysis revealed that the age, diabetes, total albumin,SII > 752.6×109 and CRP > 20.25mg/L were independent risk factors for POD patients. Incorporating these 5 factors, the model achieved a concordance index of 0.745 (95% CI, 0.683–0.808) and had a well-fitted calibration curve and good clinical application value.
Conclusion
The SII was a simple and valuable biomarker for POD, and the new nomogram model based on it can accurately forecast the occurrence of POD. They can be utilized in clinical practice to identify those at high risk of POD in older intertrochanteric fracture patients.
Effect of hydrothermal growth period on structural, morphological and thermoelectric properties of SrTiO3 /GO nanocomposites
Authors: N. Yalini Devi , K. Vijayakumar , S. Alagar Nedunchezhian A. , D. Sidharth , P. Rajasekaran , M. Arivanandhan , R. Jayavel 
Published: November 2023

Abstract
SrTiO3 and SrTiO3/GO nanocomposites were synthesized by varying hydrothermal reaction period as 12, 24 and 48 h. XRD analysis confirms the crystal structure of prepared samples. Morphological changes from spherical to cubic with increased growth period was confirmed by SEM and TEM. The functional groups in GO and SrTiO3/GO were studied by FTIR. From Raman Spectrum, Id/Ig ratio was calculated which reveals the formation of GO. The electrical resistivity of 48 h samples were relatively lower than that of other samples. Seebeck Coefficient of 24 h and 48 h samples were higher than that of as prepared sample. From the obtained Seebeck coefficient and electrical resistivity, the power factor was calculated. The 48 h sample exhibited relatively high power factor of 0.70 × 10− 6 Wm− 1K− 2 at 450 K compared to other samples. Thus, GO plays an important role in enhancing the power factor of SrTiO3/GO nanocomposites.
Dysregulated SNORD93 promotes colorectal cancer progression
Authors: Xu Yingzhi , Cai Mingzhen , 李 家明 , Wu Huihui , Zheng Tingjin , zhang zhishan 
Published: November 2023

Abstract
Background
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Recently, mounting evidence has identified dysregulated snoRNAs active in cancer by influencing cell transformation and carcinogenesis, and meanwhile, SNORD93 is abnormally expressed and associated with poor prognosis in many cancers. Thus, the present study aimed to investigate the function of SNORD93 in CRC.
Methods
The expression levels of SNORD93 were measured in CRC tissues and cells by qRT-PCR. Then, the biological significance of SNORD93 on proliferation, migration, cell cycle, and cell apoptosis with gain function analyses was explored by CCK8, colony formation, wound healing, and flow cytometry. Additionally, The expression of related proteins was quantified through Western blotting.
Result
A significant downregulation of SNORD93 was identified in CRC tissues and cells. Simultaneously, downregulated SNORD93 was considerably associated with poor survival of CRC patients. Furthermore, the overexpression of SNORD93 suppressed CRC cell proliferation via inducing G0/G1 cell cycle arrest and apoptosis, while it didn’t affect CRC cell migration.
Conclusion
SNORD93 functions as a significant tumor suppressor snoRNA in CRC.
Evaluation of cardiac function in patients with pemphigus vulgaris before and after rituximab infusion
Authors: Jafari Mahsa , Pighgahi Mehdi , Shahidi-Dadras Mohammad , Ghalamkarpour Fariba , Tehranchinia Zohreh , Abdollahimajd Fahimeh , Moravvej Hamideh , Robati Reza , Mozafari Nikoo , Namazi Nastaran , Diab Reem , Razzaghi Zahra , Toudeshki Kimia Karimi , Dadkhahfar Sahar , Nasiri Soheila 
Published: November 2023

Abstract

Background
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. Immunosuppressive drugs such as rituximab have been used as treatment of this possibly fatal disease. Rituximab infusion is associated with multiple complications such as cardiac side effects. Global strain measurement (GLS) has emerged as an important index of cardiac performance that adds incremental predictive value to standard measures such as the LVEF.
Method
This cross-sectional and prospective study was performed on patients with pemphigus vulgaris. To evaluate cardiac function, global longitudinal strain estimation, echocardiography, and ECG examination were investigated before and after the rituximab infusion.
Results
Thirty-six pemphigus vulgaris patients with a mean age of 47.86 ± 12.02 years were enrolled in this study. There was a statistically significant decrease in the mean of GLS after the rituximab infusion (p-value = 0.0001). Correlation between age and LVEF changes were significantly inverse (r=-0.378, p-value = 0.023), and correlation between age and PASP changes was significantly positive (r = 0.398, p-value = 0.002), but the correlation between age and GLS change was not statistically significant.
Conclusion
It seems that rituximab infusion may have cardiotoxic effects, leading to subclinical cardiac dysfunction, and prone these patients to EF reduction and heart failure in the future.
Isometric strength of quadriceps as a best fall predictor among older adults: analysis by machine learning approach
Authors: Madhanagopal Jagannathan , Abdulla Fuad A , Baniyasin Faris Bin , Singh Om Prakash , Kulinkumar Pandya Rutwa , Balaganapathy Murugananthan 
Published: November 2023

Abstract

This study aimed to: i) investigate which maximum voluntary isometric strength (MVIS) of lower limb muscle groups has good sensitivity (Se) and specificity (Sp) in predicting fall among older adults against the reference standard (history of fall) and their comparison with functional mobility (FM) and fear of falling (FoF); ii) identify the top three index measures in influencing fall to facilitate targeted assessment and exercise prescription by clinicians. A cross-sectional diagnostic study was conducted among one hundred and forty older adults (47 fallers) and (93 non-fallers) and recruited using consecutive sampling. The MVIS of plantar flexors, dorsiflexors, knee extensors and flexors, hip flexors, extensors, abductors, and adductors were measured using a microFET®2 hand-held dynamometer, FM using the timed up and go test, and FoF using the modified fall efficacy scale. The Se, Sp, accuracy (Ac), and precision (Pr) of all index measures against the reference standard were evaluated by four machine learning (ML) models. The top index measures in influencing fall were evaluated by mean decline in the Gini index (DGI). Among ML models, the Random Forest revealed that the MVIS of the quadriceps (Se = 81%, Sp = 90%, Ac = 87%, Pr = 80%) has the highest diagnostic features against the reference standard compared to other muscle groups, FM (Se = 48%, Sp = 75%, Ac = 66%, Pr = 50%), and FoF (Se = 46%, Sp = 79%, Ac = 68%, Pr = 53%). DGI suggests that the MVIS of quadriceps has the greatest influence on fall, followed by plantar flexors and hip flexors, while FoF has the least. These results suggest that MVIS of the quadriceps is the best fall predictor in older adults, followed by plantar flexors and hip flexors. The findings imply that clinicians can better predict and impact falls in older adults by targeting muscles with higher fall influence during intervention prescribing.
Neutrophils recruited by NKX2-1 suppression via activation of CXCLs/CXCR2 axis promote lung adenocarcinoma progression
Authors: La’ah Anita S , Tsai Ping-Hsing , Yarmishyn Aliaksandr A. , Ching Lo-Jei , Chien Yueh , Chen Jerry Chieh-Yu , Tsai Ming-Long , Chen Yi-Chen , Ma Chun , Hsu Po-Kuei , Luo Yung-Hung , Chen Yuh-Min , Lu Kai-Hsi , Chou Yu-Ting , Wang Mong-Lien , Chiou Shih-Hwa 
Published: November 2023

Abstract
Background: Lung adenocarcinoma (LUAD) progression is dependent on the immune tumor microenvironment through paracrine signaling. NKX2-1 is the lineage-specific transcription factor that serves as a well-characterized pathology marker to define LUAD with progressive impact in patients. However, the involvement of NKX2-1 in modeling the tumor immune microenvironment is still unclear. Here, we demonstrated that NKX2-1-low tumors expedite tumor progression in LUAD by recruiting tumor-promoting neutrophils.
Method: Single-cell RNA sequencing and Visium in situ capturing profiling were used to characterize the infiltration of neutrophils in orthotopic syngeneic tumors. Clinical relevance of NKX2-1 expression and disease status were evaluated by immunohistochemical analysis of LUAD tissue arrays and the overall survival analysis was performed by using TCGA dataset. Chemokine secretion was analyzed by chemokine array and validated by qRT-PCR. ATAC-seq was used to confirm the modulatory role of NKX2-1 on the chromatin accessibility of CXC chemokine genes.
Results: NKX2-1 downregulation was observed in high-grade LUAD with increased neutrophil recruitment and infiltration. NKX2-1 knockdown promoted the expression and secretion of CXCL1, CXCL2, CXCL3, and CXCL5 in LUAD cells. ATAC-seq revealed the restrictive regulation of NKX2-1 on the promoters of CXCL1, CXCL2and CXCL5. Single-cell RNA sequencing and Visium in situ capturing revealed that the infiltrated neutrophils exhibited strong cell-cell communication through the activation of CXCLs/CXCR2 signaling with increased tumor growth and vice versa when inhibited with CXCR2 antagonist SB225002.
Conclusion: This study revealed that NKX2-1 negatively regulates the infiltration of tumor-promoting neutrophils by suppressing CXCLs/CXCR2-dependent mechanisms. Hence, targeting CXCR2 in NKX2-1-low tumors is a potential antitumor therapy that may improve LUAD patient outcomes.
Alkali-Heat Treatment Enhancing Oxygen Tolerance of CO2 electroreduction to HCOOH on SnO2/CN
Authors: Su Mingxue , Guo Zhenguo , Li Ning , Zhu Bing 
Published: November 2023

Abstract
Tin oxide/carbon nitride composite catalyst (SnO2/CN) exhibits high selectivity to CO2 electroreduction reaction (eCO2RR) to HCOOH. However, industry flue gas, with the presence of O2 and relatively low CO2 concentration, inhibits the electrocatalytic activity of this kind of catalyst. In this study, alkali-heat treatment was introduced into the pretreatment process of CN carrier to improve the electrocatalytic activity and oxygen tolerance of SnO2/CN. The results of X-ray photoelectron spectroscopy confirmed that alkali-heat treatment can expose more surface amino groups of CN, enhancing the alkalinity of composite catalysts and thus the adsorption of CO2. Electron transfer occurred significantly from N of alkali-heat treated CN to Sn via enhanced metal-support interaction, forming highly electron-rich centers of Sn species and further benefiting the activation and reduction of CO2. The analysis of CO2 temperature programmed desorption also revealed that alkali-heat treatment could improve binding between catalyst and CO2. The multi-component competitive adsorption curve further indicated that alkali-heat treatment was beneficial for CO2/O2 separation as well. Finally, the electrochemical experiments demonstrated that faradaic efficiency (FE) of HCOOH reached 90.5% at a potential of -1.8V (vs. Ag/AgCl) after 2 h of eCO2RR over alkali-heat treated SnO2/CN. And in the case of simulated industry flue gas, the FE of HCOOH still reached 76.4% with the enhanced oxygen tolerance compared to untreated SnO2/CN.
Post-COVID diabetes mellitus in cross-sectional study: autoimmune disease with endothelial dysfunction?
Authors: Alieva Anna , Khalilova Dilovar , Saidova Saodat , Salimova Alinur 
Published: November 2023

Abstract

Purpose: To study the characteristics of diabetes occurring after COVID-19.
Methods: Hemostasis parameters, vitamin D, and beta cell-specific autoantibodies in 70 patients with post-COVID-19-diagnosed diabetes were tested.
Results: In our cross-sectional study, we found a relatively high incidence of type 1 DM (16.7%) and LADA (4.76%) among adults who were diagnosed with DM after COVID-19. Adult patients with type 1 DM were younger, predominantly female, and had a high rate of family history of DM. The majorityof patients with type 1 DM had mild COVID-19 and did not use corticosteroids during acute COVID-19. Patients with not only severe but also mild COVID-19 also had a risk for diabetes onset. All patients with newly diagnosed DM had low vitamin D levels, although Uzbekistan has good insolation. New cases of DM were registered within 0 to 24 months after COVID-19. The majority of type 1 cases were registered during the first 2 months and at 15-20 months after acute COVID-19. The incidence of new type 2 DM cases was consistent during the 2-year period after COVID-19.
As expected, patients with type 2 had high levels of D-dimer and von Willebrand factor. Type 1 DM patients – both adults and children – also had increased levels of D-dimer and von Willebrand factor. VCAM-1 levels were high in all patients, including children, with the highest levels in patients with LADA, indicating endothelial dysfunction.
Conclusion. The increased incidence of type 1 DM with positive diabetes-specific antibodies after COVID-19 indicates damage to islet cells and their components by SARS-CoV-2 with further activation of autoimmune mechanisms. Young females with a family history of DM who were diagnosed with diabetes after COVID-19 should be tested for diabetes-specific antibodies for proper differentiation of the type of the disease and timely insulin treatment. Type 1 DM developed after COVID-19 should be treated as a disease with cardiovascular disease with endothelial dysfunction.
Highly Efficient Anionic Ring-Opening Reactions of Epoxide Triggered by Phosphide
Authors: Ariyoshi Tomoyuki , Sudo Atsushi , Endo Takeshi 
Published: November 2023

Abstract

Potassium diphenyl phosphide (KPPh2), which forms a highly nucleophilic phosphide anion, was used as an initiator for the anionic ring-opening polymerization of glycidyl phenyl ether (GPE). GPE was selected as a model compound for the practical application of various glycidyl-type epoxy resins. MALDI-TOF MS analysis of the resulting polymer clarified the presence of a diphenyl phosphine moiety at initiation, confirming that the anionic polymerization was initiated by nucleophilic attack of the phosphide anion on the epoxide. In addition, compared to various basic catalysts such as phosphines and amines, KPPh2 catalyzed the ring-opening addition of epoxide with o-cresol much more efficiently, demonstrating its potential for application to epoxy–phenol curing systems.
Prediction of polishing roughness of aluminum alloy hard anodized film based on BP and GA-BP neural network
Authors: Wang Zeliang , Tian Bing , Kong Lingchun , Meng Qingguo 
Published: November 2023

In order to obtain better-polished surface quality of hard anodic oxide film, two deep learning models of the BP neural network and GA-BP neural network were used to establish a roughness prediction model for aluminum alloy hard anodic oxide film polishing. The experimental data was divided into two groups, one group of data was used for model training, and the other group of data was used for model testing. The results showed that the mean square error between the polishing roughness predicted by the BP neural network model and the experimental results was 1.33E-2, the maximum relative error was 18.84 %, the minimum relative error was 0.77 %, and the average relative error was 10.46 %. The error is relatively large, and the degree of variation of the error is relatively large; the mean square error of the polishing roughness predicted by the GA-BP neural network model and the test results is 0.58E-2, the maximum relative error is 14.28 %, the minimum relative error is 0.51%, the average relative error is 6.61 %, the error is smaller, and the degree of error change is smaller; the prediction accuracy of the GA-BP model is the highest, and the generalization ability strongest.
A. von Humboldt et Goethe : des épistémés relationnelles et orphiques pour connaître les formes vivantes
Authors: Guest Bertrand 
Published: November 2023

Le dialogue entre Alexander von Humboldt et Goethe souligne leur intérêt commun pour une approche de plus en plus scindée en deux champs de connaissance que leur époque tend à séparer : les sciences de la nature et la poésie, qu’ils pratiquent de concert. Ils partagent une conscience de la nature relationnelle du monde comme du savoir, le second devant pour eux se concevoir au contact et à l’image du premier. Leur amitié créatrice et leur Bildung mutuelle sont riches de suggestions épistémologiques toujours des plus actuelles, au moment où l’écologie, en tant que science des relations et interactions au sein du vivant, entrevoit de plus en plus la nécessité d’une connaissance sensible du monde. On repère en partage chez eux une manière commune de pratiquer des sciences vivantes, soucieuses de ne pas bouleverser ce qu’elles observent, en ce sens orphiques.
Mots-clés : zoopoétique, animal, écologie, relation, vulnérabilité.
Senancour écocritique : la conception pastorale
Authors: Le Scanff Yvon 
Published: November 2023

Le rapport de l’homme avec la nature est tout autant un rapport de l’homme avec sa nature. C’est l’apport fondamental de la pensée de la nature chez Étienne Pivert de Senancour (1770-1846). L’auteur indique les chemins méthodiques d’une conversion de l’humain vers le naturel en identifiant de façon problématique les voies déviantes de l’anthropisation. Son analyse relève différentes directions qui dessinent une forme d’égarement qui font sens, mais aussi contre-sens : l’illusion d’une destination conçue comme extension indéfinie, mais aussi comme dénaturation et égale dévaluation de l’homme et de la nature. Face à cela, Senancour propose une forme de restauration de la valeur, d’une valeur d’usage de la nature, et une réévaluation de la place et de la mission de l’homme dans ce qu’on pourrait appeler une nouvelle conception pastorale.
Mots-clés : Senancour, nature, pastorale (vie), romantisme, écocritique.
Ordres et désordres des jardins de George Sand
Authors: Fournier Kiss Corinne 
Published: November 2023

Dans les jardins, les apparences sont trompeuses, et l’ordre et le désordre ne sont pas toujours là où l’on pense. Si dans un premier temps, les jardins bien « arrangés » représentés dans les oeuvres de George Sand suscitent invariablement la surprise émerveillée de l’autrice ou de ses personnages, ils finissent cependant par décevoir, car un certain ordre leur fait défaut. Par opposition, les jardins que Sand définit comme « naturels », où la végétation est abandonnée à elle-même et libre de pousser à tort et à travers, révèlent à qui sait le voir un ordre indéfectible. Comment expliquer ce paradoxe ? La prise en considération des débats scientifiques ayant eu lieu à l’époque de Sand permettra en partie de le résoudre.
Mots-clés : flore indigène, flore exotique, jardin naturel, jardin arrangé, ordre, relationalité, débat Cuvier-Geoffroy Saint-Hilaire, géographie des plantes.