bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight into Hydrodynamics Behavior of Creeping Flow of Couple Stress Fluid Through Uniformly Porous Rectangular Channel under the Influence of Walls Slip; An analytical approach.
Authors: Ishaq Muhammad , Rehman Saif Ur , Afzal Farkhanda , Alshomrani Ali Saleh , Inc Mustafa 
Published: November 2023

Abstract
In this paper, we have obtained the exact solution for the slip effects on the creeping flow of a couple stress fluid through a uniformly porous walled channel. The momentum equations have been transformed into a stream function using the inverse method. Expressions for important physical quantities such as longitudinal velocity, transverse velocity, fractional reabsorption, leakage flux, axial pressure, volume flow rate, and mean pressure have been derived. Results have been presented graphically, demonstrating that the longitudinal velocity is influenced by the initial flow rate while the transverse velocity remains unaffected by the initial flow rate. Moreover, it has been shown that there are no detectable slip effects on the physical quantities studied. Notably, the initial flow rate significantly impacts the streamlines; an increase in flow rate straightens and aligns the streamlines, whereas a decrease leads to backward flow. The volume flow rate exhibits a substantial impact on longitudinal velocity, but no influence on transverse velocity is observed. This study holds the potential to assist bioengineers in designing medical tools with required pressure and flow rate specifications. The application of this model is particularly relevant to hemodialyzers.
Hydrodynamics of Incompressible Creeping Couple Stress Fluid Through a Uniformly Porous Channel in Presence of Darcy Resistance: Exact Solution and Physical Insights Using the Inverse Method Approach
Authors: Ishaq Muhammad , Fatima Nosheen , Afzal Farkhanda , Alshomrani Ali Saleh , Inc Mustafa 
Published: November 2023

Abstract
The current study examines the features of a two-dimensional steady incompressible flow of creeping couple stress fluid across a permeable channel with uniform reabsorption. The mathematical model that governs this flow is composed of linear partial differential equations and homogeneous boundary constraints. The Inverse method approach, an analytical technique, is used to find solutions to the problem. By converting the momentum equations to stream functions, the inverse approach helps derive all the relevant physical quantities, including the longitudinal and transverse velocities, fractional reabsorption, leakage flux, axial pressure, volume flow rate, and mean pressure. Using MATLAB software, the dependent functions such as stream function, pressure, and volume flow are evaluated for different parameter values. The findings indicate that the longitudinal velocity is affected by the initial flow rate, while the transverse velocity shows no change in its profile. The streamlines become more straight and identical as the flow rate increases. Backward flow occurs at the end of the slit due to the porosity parameter. However, the initial flow rate does not impact the transverse velocity of the fluid in the permeable channel. This study fully describes a mathematical foundation for understanding fluid movement across permeable boundaries, which have practical applications in areas such as gaseous diffusion, filtration, and biological mechanisms.
Effects of indole-3-butyric acid supplementation in diets containing high soybean meal on growth, intestinal inflammation, and intestinal flora of pearl gentian grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatu♂)
Authors: Pang Aobo , Zhang Sen , Dong Shaohan , Zhang Xianxin , Liang Junhui , Fang Yanxin , Tan Beiping , Zhang Wei 
Published: November 2023

Abstract

Soybean meal and its processing products have been widely used in fish feeds. In aquaculture, there is a lack of effective targeted protection against food-borne enteritis caused by feeding soybean meal. Our preliminary research found that Indole-3-butyric acid (IBA) has the potential application value. The present research evaluated the influence of supplementing different levels of IBA to diets containing high soybean meal on alleviating intestinal inflammation in juvenile pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂). The feeding experiment lasted for eight weeks. The FM diet with fish meal as the main protein source was prepared. In addition, six diets were prepared in which soybean meal was used to replace some of the fish meal as a secondary protein source. IBA was added to these six diets at 0 g/kg, 0.8 g/kg, 1.6 g/kg, 2.4 g/kg, 3.2 g/kg, and 4.0 g/kg, respectively. The use of soybean meal to replace some of the fish meal in the diet resulted in weakened growth performance of the fish. Growth inhibition due to SBM ingestion was significantly reduced in fish fed diet supplemented with 2.4 g/kg IBA. Feeding the SBM diets caused a severe inflammatory reaction in the distal intestine of the fish, and IBA helped to suppress the inflammation, as evidenced by changes in histological characteristics, immune-related biochemical index levels, and immune-related gene expression levels between the groups. In addition, this study investigated the role of IBA feeding on fish from the perspective of intestinal flora. IBA interacts with the intestinal flora, leaving the intestinal flora of fish with enteritis in a recovering state. These findings provide a theoretical basis for IBA to mitigate SBMIE in pearl gentian grouper and promote the further application of soybean meal in carnivorous fish.
Identification of T cell exhaustion-related genes in clear cell renal cell carcinoma and construction of a prognostic model
Authors: Wang Qi , Wu Wensong , Aisha Awuti , Xin Jiayan , Chang Fan , Zhang Jianghui , Tang Shuai , Lv Zheng , Chen Fangmin 
Published: November 2023

Abstract
Background: T cell exhaustion (TEX) is associated with tumor progression and the efficacy of immunotherapy. The aim of this study is to investigate TEX-related genes in clear cell renal cell carcinoma(ccRCC), identify their key genes, and construct a prognostic model based on TEX-related genes.
Method: Tumor and normal samples of ccRCC were obtained from TCGA. WGCNA was employed to screen TEX-related genes, while MCODE was used to filter hub genes. Analysis of hub gene differential expression between tumor and normal tissues was conducted alongside immune cell correlation assessments. Renal cancer patients were stratified into two subgroups via clustering analysis, enabling comparison of TEX-related gene expression and immune cell infiltration between these groups. Subsequently, a prognostic model was constructed using lasso regression analysis, evaluating the correlation between risk scores, clinical features, immunotherapeutic efficacy, and IC50 of chemotherapy drugs. External validation of the model was performed using ICGC datasets.
Results：In our study, we identified 5 hub genes among 185 TEX-related genes in ccRCC, all of which exhibited a positive correlation with T cell infiltration. The high expression subgroup of TEX- related genes displayed lower survival rates compared to the low-expression subgroup. Our developed prognostic model effectively predicts overall patient survival, demonstrating high accuracy via ROC curve analysis. Additionally, increased risk scores were associated with poorer clinical features, diminished immunotherapeutic efficacy, and higher IC50 values for chemotherapy drugs.
Conclusion:The TEX-related genes we identified may potentially serve as novel targets for the treatment of advanced-stage renal cancer. Moreover, the TEX-related prognostic model could serve as an effective tool for predicting outcomes in renal cancer patients.
Targeting SARS-CoV-2 main protease 3CL pro and human ACE2 with Paeonia Phytochemicals by in silico and in vitro Studies in Terms of Possible COVID- 19 Therapeutics
Authors: Bostancioglu Safiye Merve , Sandalli Aytul , Almohazey Dana , Alsaeed Moneerah , Alhamid Galyah , Rabaan Ali , Turumtay Emine Akyuz , Turumtay Halbay , Innocent David Chinaecherem , Tombuloglu Huseyin 
Published: November 2023

Abstract
As important medicinal herbs, Paeonia species have been used in ancient medicine. Although its therapeutic potential is well known, the potential efficacy of Paeonia phytochemicals against the emerging coronavirus (SARS-CoV-2) has yet to be tested. This study selected seventy-six Paeonia compounds to determine their potential druggable impact on SARS-CoV-2 main protease (3CLpro) and human ACE2 proteins. Structure-based virtual screening (SBVS) approach was performed by PyRx molecular docking software, including the Open Babel v2.4 and AutoDock 4.2.6 tools. The lowest affinity score and desired hydrogen bonding interactions were selected, and SwissADME was used to predict drug-likeness and pharmacokinetics properties. In addition, the potential cytotoxic effect of five Paeonia root extracts was tested in cancer (HCT116 and HeLa) and fibroblast (HFF) cell lines. The results showed that nine Paeonia ligands (catechin, apigenin, palbinone, kaempferol, paeoniflorigenone, eriodictyol, paeonilactone C, cassythicine, and 3-O-methylquercetin) were able to interact with SARS-CoV-2 at high affinity (from − 7.5 to -9.0 kJ/mol), as possible SARS-CoV-2 inhibitors. Molecular dynamics simulation (MDS) analysis revealed that five of these phytochemicals -cathecin, apigenin, palbinone, paeoniflorigenone, and eriadictyol- have the potential to act as effective compounds. In addition, the plant extracts at low concentrations is not cytotoxic for selected cell lines. Overall, this study points to the inhibitory potential of Paeonia phytochemicals as novel therapeutics against SARS-CoV-2. Their druggable potential can be tested in vivo in further studies.
The Contribution of Artificial Intelligence in Blind Equalization Using SOSA-MIMO Algorithm with QOSTBC Coding
Authors: Abderrazak Derbale , Abdessalam Bassou 
Published: November 2023

Abstract
The recent evolution in communications forces us to rely on AI to improve the quality of communications. Artificial intelligence has become one of the necessities in the development of scientific life. In this article, we integrate artificial intelligence into blind equalization using the coding technique QOSTBC with Multi-input Multi-output (MIMO) transmission. The Multi-input Multi-output (MIMO) transmission and the blind equalizer schemes by using the QOSTBC coding have become the techniques of choice for increasing spectral efficiency in bandwidth-congested areas are hit in demand nowadays, especially in mobile applications, where devices with size, weight, and power constraints are common. In this paper, we propose a new blind equalizer using the second-order statistical algorithm in a MIMO system with QOSTBC coding used. QOSTBCs with MIMO-SOSA are used to enhance the energy efficiency of the communication system with 8; 4 and 2 antennas. We obtain the optimal performance that ensures full diversity and maximizes the QOSTBC minimum coding gain distance. Simulation results are presented for MIMO-SOSA under 5g wireless Rayleigh channels so that a fair performance comparison with other reference techniques can be established. The results show that by using MIMO-SOSA along with a coding QOSTBC and with diversity in the fading channel and thus low BER at high SNR can be ensured. More importantly, it is also shown that QOSTBC using MIMO-SOSA achieves a better error performance than those using conventional modulation format.
Monitoring the Landscape Pattern Dynamics and Driving Forces in Dongting Lake Wetland in China Based on Landsat Images
Authors: Guo Mengshen , Zhou Nianqing , Cai Yi , Zhao Wengang , Lu Shuaishuai , Liu Kehao 
Published: November 2023

Abstract

Dongting Lake wetland is a typical lake wetland in the Middle and Lower Yangtze River Plain in China. Due to the influence of natural and human activities, the landscape pattern has changed significantly. 12 Landsat images of Dongting Lake wetland from 1991 to 2022 were extracted and classified based on the CART decision tree method. The dynamic characteristics of wetland vegetation spatial pattern changes were analyzed using landscape pattern index, dynamic degree model and transition matrix model. Redundancy analysis and grey correlation analysis methods were used to explore the driving factors. The results showed that in the past 32 years, the fragmentation degree of Dongting Lake wetland landscape has increased, the heterogeneity has decreased and the landscape shape has become more complex. The mutual conversion of mudflat and water was one of the forms of landscape transformation, while the mutual conversion of sedge and reed area was the main trend of vegetation landscape change. Water level had the greatest contribution to wetland landscape fragmentation, with the lower the water level, the greater the degree of landscape fragmentation. Human activities were the most important driving force, especially the policy changes in reed and woodland, as well as the establishment of the Three Gorges Dam, which have a significant impact on the landscape change pattern and ecological function of wetland. The research results are of great significance for wetland ecological restoration and environmental protection, providing scientific support for government management and decision-making.
Bio-mimetic sensing characteristics of differently synthesized polyanilines towards the surrounding electrical and chemical energetic conditions
Authors: Rajan Lijin , Sidheekha Madari Palliyalil , Shabeeba Aranhikundan , Rajan Ayana , Krishnendu Thamburan Vathukkal , Ismail Yahya A. 
Published: November 2023

Abstract
Conducting polymers are recognized as responsive gels capable of responding to the changes in their surrounding environment through their unique electrochemical response. Various polyanilines at different reaction time were synthesized chemically and their properties were examined using TGA, UV-VIS spectroscopy, FTIR spectroscopy, cyclic voltammetry (CV) and coulovoltammetry (QV). To investigate their electrochemical sensing capabilities towards both electrical and chemical stimuli, the chronopotentiometric responses in HCl solutions were monitored by varying the working variables: the applied current and electrolyte concentration, at a constant charge obtained from respective QV. The consumed electrical energy during the electrochemical reaction was observed to change linearly with the driving current, while a logarithmic relationship was established with the electrolyte concentration. The electrical energy served as the sensing parameter, and the sensitivity was found to be associated with the reaction time during synthesis of the polymers, with longer chains exhibiting greater sensitivity. The experimental findings were validated using a theoretical equation. Applicability of polyaniline to act as a model material for designing bio-mimetic sensing devices using only two connecting wires is verified here as they mimic the electrochemical reactions of biological muscles comprising of natural polymeric chain.
Utility of Contrast-Enhanced MRI Radiomics Features combined with clinical indicators for Predicting Induction Chemotherapy Response in Primary Central Nervous System Lymphoma
Authors: Wang Xiaochen , Zhao Litao , Wang Sihui , Zhao Xuening , Chen Lingxu , Sun Xuefei , Liu Yuanbo , Liu Jiangang , Sun Shengjun 
Published: November 2023

Abstract
Purpose To evaluate the utility of contrast-enhanced magnetic resonance imaging (CE-MRI) radiomics features combined with clinical variables to predict induction chemotherapy (IC) response when treating primary central nervous system lymphoma (PCNSL).
Methods A total of 131 patients with PCNSL (101 in the training set and 30 in the testing set) who had had contrast-enhanced MRI scans were retrospectively analyzed. Pyradiomics was used to extract radiomics features, and the clinical variables of the patients were collected. Radiomics prediction models were constructed using different combinations of feature selection methods and machine learning models, from which the best combination was selected. We screened clinical variables associated with treatment outcome and developed clinical prediction models. The prediction performance of radiomics model, clinical model, and combined model, which integrates the best radiomics model and clinical characteristics was independently assessed and compared using Receiver Operating Characteristic (ROC) curves.
Results In total, we extracted 1598 features. The best radiomics model we chose used T-test and RFE for feature selection and logistic regression for model building. Serum Interleukin 2 Receptor (IL-2R) and ECOG Score were used to construct a clinical predictive model of induction chemotherapy response. The results of the test set showed that the combined prediction model (radiomics and IL-2R) had the highest area under the ROC curve at 0.868 (0.683,0.967), followed by the radiomics model at 0.857 (0.681,0.957), and the clinical prediction model (IL-2R and ECOG) at 0.618 (0.413,0.797). The combined model was significantly more accurate than the clinical model (AUC, 0.868 vs. 0.618, P < 0.05). While the radiomics model had slightly better predictive power than the clinical model, this difference was not statistically significant (AUC, 0.857 vs. 0.618, P > 0.05).
Conclusions Our prediction model, which combines radiomics signatures from CE-MRI with serum IL-2R, can effectively stratify PCNSL patients before high-dose Methotrexate (HD-MTX) based chemotherapy.
Losartan and Metamorphopsia
Authors: Mehrotra-Varma Jai , Thinda Sumeer 
Published: November 2023

Abstract
Background:
Losartan, a commonly used hypertension medication, is associated with rare neurological side effects. This report presents the first case of losartan-linked bilateral metamorphopsia - a distortion of visual perception.
Case Presentation:
A 65-year-old woman with hypertension and myopic degeneration developed bilateral metamorphopsia while taking losartan. Despite normal retinal exams and neuroimaging, the symptoms persisted. Discontinuation of losartan led to symptom resolution over one year with no recurrence.
Conclusions:
This unique case emphasizes the need to evaluate drug-related adverse events in clinical diagnoses. Losartan's potential impact on the midbrain's visual processing regions may explain the observed visual disturbances. Further research is needed to explore this connection.
Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimation
Authors: Stephens Zachary , Kocher Jean-Pierre 
Published: November 2023

Abstract
Telomeres are regions of repetitive DNA at the ends of linear chromosomes which protect chromosome ends from degradation. Telomere lengths have been extensively studied in the context of aging and disease, though most studies use average telomere lengths which are of limited utility. We present a method for identifying all 92 telomere alleles from long read sequencing data. Individual telomeres are identified using variant repeats proximal to telomere regions, which are unique across alleles. This high-throughput and high-resolution characterization of telomeres could be foundational to future studies investigating the roles of specific telomeres in aging and disease.
Correlations between ATF3 polymorphisms and ischemic stroke in Dali, Yunnan Province, as determined by a case-control study
Authors: Yang Yunhui , Wang Pengyu , Wang Min , Wang Guangming 
Published: November 2023

Abstract
Background: Genetic factors play an important role in ischemic stroke (IS) onset. Activating transcription factor 3 (ATF3) is a known IS biomarker; however, the association between ATF3polymorphisms and susceptibility to IS remains unclear. Therefore, we aimed to explore the association between ATF3single-nucleotide polymorphisms (SNPs) and genetic susceptibility to IS in a population in Dali, Yunnan, China.
Methods: We included 145 patients with IS and 127 healthy controls in this case-control study. ATF3SNP sites (rs1105899, rs1008737, rs1195474, and rs1195472) were genotyped using SNaPshot detection.
Results: Venous serum glucose (VSG), white blood cell count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and systolic blood pressure (SBP) were IS risk factors; VSG had the highest impact on IS susceptibility, whereas SBP had the lowest. Genotype distributions of rs1105899, rs1008737, and rs1195472 polymorphisms in the control group conformed to the Hardy–Weinberg equilibrium. Association analysis between ATF3 polymorphisms and IS risk showed that rs1105899, rs1008737, and rs1195474 ATF3 polymorphisms were not significantly associated with IS risk. In the codominant and superdominant model of the rs1195472 [C/T] loci, CT carriers exhibited a lower IS risk than CT and TT carriers. Haplotype AGAC was an inhibitory factor for IS. The GTEx database showed that the rs1195472 CT genotype increased ATF3 expression and was associated with its expression in individual tissues.
Conclusion: The rs1195472 polymorphism was associated with IS risk in our study population; no significant correlation was noted between rs1105899, rs1008737, and rs1195474 polymorphisms and IS.
Educação para a democracia
Authors: Matielo Etel , Artmann Elizabeth 
Published: November 2023

Denominamos agir comunicativo-pedagógico a relação entre comunicação e educação, fundamentada em dois importantes postulados epistêmicos, a teoria do agir comunicativo por Jürgen Habermas, e as bases pedagógicas de Paulo Freire (com o olhar da educação popular em saúde). Este ensaio tem como objetivo refletir como o agir comunicativo-pedagógico pode contribuir para a reflexão sobre processos de formação na área da saúde, pautada nas categorias convergentes destes dois autores como: comunicação/diálogo, interdisciplinaridade, democracia, trabalho e emancipação. O agir pedagógico fundamenta-se nas aprendizagens sociais apoiadas na racionalidade comunicativa, de forma a viabilizar uma cultura dialógica, solidária e radicalmente aberta aos processos de transformação pautados na emancipação social. No agir comunicativo, que articula todos os tipos de ação (Teleológica, Estratégica, Normativa e Comunicativa), os falantes vivenciam experiências que oportunizam consensos e entendimentos. Se estabelece uma relação interna entre práxis e racionalidade, elevando o conteúdo normativo da ação orientada para o entendimento recíproco. Habermas e Freire desenvolvem propostas de ações comunicativas que são profundamente interligadas, motivo pelo qual relaciona-se o papel da comunicação nas relações humanas e consequentemente na saúde. A integração do agir comunicativo com elementos da educação popular potencializa a ação pedagógica. Nessa perspectiva, a linguagem passa a assumir as funções de entendimento e coordenação das atividades orientadas por fins dos diferentes sujeitos da ação e o meio da própria socialização. Logo, a linguagem expressa na fala ou gestos constitui-se por resultados da ação social, que pelo compartilhamento torna-se capaz de produzir mudanças e intervenções significativas nos processos formativos em saúde.