bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic Subunit of Human Telomerase Reverse Transcriptase Is an Independent Predictor of Survival in Patients Undergoing Curative Resection of Hepatic Colorectal Metastases: A Multicenter Analysis
Authors: Dômont Julien , Pawlik Timothy M. , Boige Valérie , Rose Mathieu , Weber Jean-Christophe , Hoff Paulo M. , Brown Thomas D. , Zorzi Daria , Morat Luc , Pignon Jean-Pierre , Rashid Asif , Jaeck Daniel , Sabatier Laure , Elias Dominique , Tursz Thomas , Soria Jean-Charles , Vauthey Jean-Nicolas 
Published: April 2005

Purpose To determine the role of the catalytic subunit of human telomerase reverse transcriptase (hTERT) in predicting survival after resection of hepatic colorectal metastases (CRM). Patients and Methods Two hundred one patients who underwent curative resection of hepatic CRM between 1990 and 2000 were identified from a multicenter database. The CRM were analyzed for hTERT nucleolar expression by standard immunohistochemical techniques. hTERT expression and known clinicopathologic factors of survival were examined. Results With a median follow-up of 80 months, 152 patients (75.6%) had died; the 5-year overall survival was 30.7%. On univariate analysis, number of metastases greater than two (P = .0005), extrahepatic disease (P = .0054), disease-free interval less than 12 months (P = .006), carcinoembryonic antigen level greater than 200 ng/mL (P = .0071), and positive hTERT nucleolar staining (P < .0001) were associated with decreased survival. On multivariate analysis, three factors independently predicted survival: number of metastases (relative risk [RR] = 1.74; P = .0011); disease-free interval (RR = 1.70; P = .0035); and positive hTERT nucleolar staining (RR = 2.03; P < .0001). Patients with none or one of these factors had a 5-year survival rate of 48%, whereas those with two or three of these factors had a 5-year survival of 15% (P < .0001). Conclusion hTERT nucleolar expression is associated with worse survival after resection of hepatic CRM. hTERT expression in conjunction with number of hepatic metastases and disease-free interval may permit more accurate prediction of survival after resection of hepatic CRM.
Time From Treatment to Subsequent Diagnosis of Brain Metastases in Stage III Non–Small-Cell Lung Cancer: A Retrospective Review by the Southwest Oncology Group
Authors: Gaspar Laurie E. , Chansky Kari , Albain Kathy S. , Vallieres Eric , Rusch Valerie , Crowley John J. , Livingston Robert B. , Gandara David R. 
Published: April 2005

Purpose A retrospective review of the Southwest Oncology Group (SWOG) database was undertaken to review the incidence and timing of diagnosis of brain metastases in patients undergoing combined-modality therapy for stage III non–small-cell lung cancer (NSCLC). Patients and Methods Four hundred twenty-two eligible, assessable patients with stage IIIA/B NSCLC were treated on four SWOG protocols. Treatment varied with protocol but consisted of concurrent cisplatin-etoposide and radiation in all patients, with a surgery arm in two of the four protocols. Results Of the 422 total patients, 268 (64%) have experienced disease progression; 54 relapses (20%) were in brain only, 17 (6.5%) were in brain and other sites simultaneously, and 197 (63.5%) were in sites other than brain. Of the 268 patients with disease progression, progression in the brain only, in the brain and other sites, and not in the brain occurred in 20%, 6%, and 74% of patients, respectively. Time from treatment to diagnosis of disease progression in the brain in 71 patients was as follows: during treatment, 16 relapses (22.5%); 0 to 16 weeks after treatment, 17 relapses (24%); 16 weeks to 6 months after treatment, 10 relapses (14%); 6 to 12 months after treatment, 16 relapses (22.5%); and more than 12 months after treatment, 12 relapses (17%). Nonsquamous histology and young patient age were the only significant predictors for increased risk of early relapse with brain metastases. Conclusion Brain metastases often develop early in the course of treatment for stage IIIA/B NSCLC. The statistical designs of ongoing trials of prophylactic cranial irradiation in stage III NSCLC have taken this into account.
Depression, Correlates of Depression, and Receipt of Depression Care Among Low-Income Women With Breast or Gynecologic Cancer
Authors: Ell Kathleen , Sanchez Kathleen , Vourlekis Betsy , Lee Pey-Jiuan , Dwight-Johnson Megan , Lagomasino Isabel , Muderspach Laila , Russell Christy 
Published: April 2005

Purpose To assess the prevalence of depression among low-income, ethnic minority women with breast or gynecologic cancer, receipt of antidepressant medications or counseling services, and correlates of depression. Patients and Methods Study patients were 472 women receiving cancer care in an urban public medical center. Women had a primary diagnosis of breast (stage 0 to III) or gynecologic cancer (International Federation of Gynecology and Obstetrics stage 0 to IIIB). A diagnostic depression screen and baseline questionnaire were administered before or during active treatment or during active follow-up. Self-report data were collected on receipt of depression treatment, use of supportive counseling, pain and receipt of pain medication, functional status and well-being, and perceived barriers to cancer care. Results Twenty-four percent of women reported moderate to severe levels of depressive disorder (30% of breast cancer patients and 17% of gynecologic cancer patients). Only 12% of women meeting criteria for major depression reported currently receiving medications for depression, and only 5% of women reported seeing a counselor or participating in a cancer support group. Neither cancer stage nor treatment status was correlated with depression. Primary diagnosis of breast cancer, younger age, greater functional impairment, poorer social and family well-being, anxiety, comorbid arthritis, and fears about treatment side effects were correlated with depression. Conclusion Findings indicate that depressive disorder among ethnic minority, low-income women with breast or gynecologic cancer is prevalent and is correlated with pain, anxiety, and health-related quality of life. Because these women are unlikely to receive depression treatment or supportive counseling, there is a need for routine screening, evaluation, and treatment in this population.
Clinicopathologic Behavior of Gastric Adenocarcinoma in Hispanic Patients: Analysis of a Single Institution's Experience Over 15 Years
Authors: Yao James C. , Tseng Jennifer F. , Worah Samidha , Hess Kenneth R. , Mansfield Paul F. , Crane Christopher H. , Schnirer Isac I. , Reddy Satish , Chiang Silvia S. , Najam Azmeena , Yu Christina , Giacco Geoffrey G. , Xie Keping , Wu Tsung-Teh , Feig Barry W. , Pisters Peter W.T. , Ajani Jaffer A. 
Published: April 2005

PurposeTo determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center.Patients and MethodsMedical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the χ2test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates.ResultsOf 1,897 patients, 301 (15.9%) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 ± 14.4 years v 59.4 ± 12.7 years, respectively; P < .005) or African Americans (57.6 ± 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9% v 59.5%, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5%) than whites (27.4%) and African Americans (32.5%; P < .005). Hispanics were more likely to require total gastrectomy (51%) compared with whites (38%), African Americans (38%), and Asians (36%; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30% v 44%, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54% v 41% and 47%, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival.ConclusionHispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.
Central Venous Lines in Children With Lesser Risk Acute Lymphoblastic Leukemia: Optimal Type and Timing of Placement
Authors: McLean Thomas W. , Fisher Christen J. , Snively Beverly M. , Chauvenet Allen R. 
Published: April 2005

Purpose In pediatric patients with acute lymphoblastic leukemia (ALL), the optimal time for central venous line (CVL) insertion and the optimal type of CVL (internal v external) is unclear. This study was undertaken to compare complication rates between early versus late line insertion, and between internal versus external lines in children with lesser risk ALL. Patients and Methods We performed a retrospective analysis of patients enrolled onto Pediatric Oncology Group (POG) protocol 9201. Data regarding demographics, CVL types and insertion dates, blood counts, and complications were reviewed through week 25 of therapy. Results Of 697 patients enrolled onto POG protocol 9201, 362 patients had sufficient data for analysis. When compared to late line placement (> day 15 of induction), early CVL placement (≤ day 15 of induction) was associated with an increased risk of having a positive blood culture (odds ratio, 2.2; 95% CI, 1.0 to 5.0; P = .05). When compared with internal CVLs (“ports”), external CVLs were associated with a positive blood culture (odds ratio, 3.1; 95% CI, 1.3 to 7.5; P = .01), thrombosis (odds ratio, 3.9; 95% CI, 1.5 to 10.3; P = .006), and CVL removal (odds ratio, 5.6; 95% CI, 2.7 to 11.6; P < .001). Conclusion In pediatric patients with lesser risk ALL, internal lines (ports) should be the preferred CVL type due to a lower risk of infectious and thrombotic complications. In addition, CVLs placed early in induction are associated with a higher risk of positive blood culture than those placed later in induction.
Enantio‐ and Diastereoselective Michael Reaction of 1,3‐Dicarbonyl Compounds to Nitroolefins Catalyzed by a Bifunctional Thiourea.
Authors: Okino Tomotaka , Hoashi Yasutaka , Furukawa Tomihiro , Xu Xuenong , Takemoto Yoshiji 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclization of Functionalized Heterocumulenes with C,N‐ and C,O‐Binucleophiles. Part 5. Synthesis of Imidazo[1,5‐a]imidazole Derivatives by Cyclocondensation of 1‐Chloroalkyl Isocyanates with Imidazoles and Benzimidazole.
Authors: Vovk M. V. , Sukach V. A. , Pinchuk A. M. , Chernega A. N. , Pirozhenko V. V. , Howard J. A. K. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Mild, Selective, and High‐Yield Oxidation of Hantzsch 1,4‐Dihydropyridines with Lead(IV) Acetate.
Authors: Litvic Mladen , Cepanec Ivica , Filipan Mirela , Kos Karmen , Bartolincic Anamarija , Druskovic Vinka , Tibi Mohamed Majed , Vinkovic Vladimir 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel 5‐Trifluoromethyl‐2,4,7‐trisubstituted Pyrido[2,3‐d]pyrimidines.
Authors: Ravikanth S. , Reddy G. Venkat , Maitraie D. , Rao V. V. V. N. S. Rama , Rao P. Shanthan , Narsaiah B. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclization of Functionalized Heterocumulenes with C,N‐ and C,O‐Binucleophiles. Part 4. Reactions of 1‐Chloroalkylheterocumulenes and N‐(1‐Chloroalkylidene)carbamates with 2‐Benzimidazolylacetonitriles and Methyl 2‐Benzimidazolylacetates.
Authors: Vovk M. V. , Lebed' P. S. , Pirozhenko V. V. , Tsymbal I. F. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3,4,5‐Tris(alkyloxy)benzyl Glycosides and Glycolipid Analogues.
Authors: Sato Reiko , Toma Kazunori , Nomura Kazufumi , Takagi Mutsumi , Yoshida Yoshiomi , Azefu Yasuo , Tamiaki Hitoshi 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Homer expression in the Xenopus tadpole nervous system
Authors: Foa Lisa , Jensen Kendall , Rajan Indrani , Bronson Kim , Gasperini Robert , Worley Paul F. , Tu Jian C. , Cline Hollis T. 
Published: April 2005

AbstractHomer proteins are integral components of the postsynaptic density and are thought to function in synaptogenesis and plasticity. In addition, overexpression of Homer in the developing Xenopus retinotectal system results in axonal pathfinding errors. Here we report that Xenopus contains the homer1 gene, expressed as the isoform, xhomer1b, which is highly homologous to the mammalian homer1b. The mammalian homer1 gene is expressed as three isoforms, the truncated or short form homer1a and the long forms homer1b and ‐1c. For Xenopus, we cloned three very similar variants of homer1b, identified as Xenopus xhomer1b.1, xhomer1b.2, and xhomer1b.3, which display up to 98% homology with each other and 90% similarity to mammalian homer1b. Furthermore, we demonstrate that Xenopus also contains a truncated form of the Homer1 protein, which could be induced by kainic acid injection and is likely homologous to the mammalian Homer1a. xHomer1b expression was unaffected by neuronal activity levels but was developmentally regulated. Within the brain, the spatial and temporal distributions of both Homer isoforms were similar in the neuropil and cell body regions. Homer1 was detected in motor axons. Differential distribution of the two isoforms was apparent: Homer1b immunoreactivity was prominent at junctions between soma and the ventricular surface; in the retina, the Mueller radial glia were immunoreactive for Homer1, but not Homer1b, suggesting the retinal glia contain only the Homer1a isoform. Homer1b expression in muscle was prominent throughout development and was aligned with the actin striations in skeletal muscle. The high level of conservation of the xhomer1 gene and the protein expression in the developing nervous system suggest that Homer1 expression may be important for normal neuronal circuit development. J. Comp. Neurol. 487:42–53, 2005. © 2005 Wiley‐Liss, Inc.
Distribution of galanin‐like immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri)
Authors: Adrio Fátima , Rodríguez Miguel Ángel , Rodríguez‐Moldes Isabel 
Published: April 2005

AbstractGalanin is a 29‐amino acid peptide widely distributed in the central nervous system of vertebrates. The organization of galaninergic systems is well known in teleosts, the most advanced actinopterygians, but no data are available on primitive bony fish. To extend the evolutionary analysis of galaninergic systems we studied the distribution of galanin‐like immunoreactive (GAL‐ir) cells and fibers in the sturgeon brain, since chondrosteans are among the most primitive extant actinopterygians. Double‐immunolabeling experiments were performed to compare the distribution of galanin with that of neurophysin, tyrosine hydroxylase, and serotonin. Numerous GAL‐ir cells of cerebrospinal fluid‐contacting (CSF‐C) type were found in the ventral telencephalon, preoptic area, and in the tuberal and caudal hypothalamus. The distribution of GAL‐ir elements in the sturgeon brain shows many similarities to that observed in other vertebrates, but also important differences, such as the abundance of GAL‐ir CSF‐C cells, which appear to be a primitive characteristic. GAL‐ir neurons observed in the sturgeon telencephalic hemispheres perhaps represent the basic organization of common ancestors of bony fishes and tetrapods. In the preoptic‐hypophyseal system, GAL‐ir cells appeared to be related not only with neurophysin‐expressing neurons (in the tuberal hypothalamus) but also with serotoninergic and catecholamines‐synthesizing neurons (in preoptic and tuberal nuclei). Numerous GAL‐ir fibers were observed in the median eminence and neural lobe of the hypophysis, indicating that galanin may play a role in the modulation of hypophyseal secretion. GAL‐ir neurons were absent from the sturgeon brainstem, suggesting that their presence in other vertebrates could represent an evolutionary recent acquisition. J. Comp. Neurol. 487:54–74, 2005. © 2005 Wiley‐Liss, Inc.
Synthesis, Crystal Structure and Magnetic Properties of Heterodimetallic ReIVCuII Complexes
Authors: Tomkiewicz Alina , Mroziński Jerzy , Brüdgam Irene , Hartl Hans 
Published: April 2005

AbstractThe two rhenium(IV)‐copper(II) heterometallic complexes [CuLβ][ReCl4(ox)]·DMF (1) and [(CuLα)2Cl][ReCl4(ox)]Cl (2) (Lβ = N‐dl‐5,7,7,12,14,14‐hexamethyl‐1,4,8,11‐tetraazacyclotetradeca‐4,11‐diene and Lα = N‐dl‐5,7,7,12,12,14‐hexamethyl‐1,4,8,11‐tetraazacyclotetradeca‐4,14‐diene) were synthesized, and the crystal structures of both compounds were determined at 173(2) K. Complex 1 crystallizes in a monoclinic space group P21, with a = 9.365(2) Å, b = 15.150(2) Å, c = 10.776(1) Å, β = 110.01(1)°, Z = 2, whereas 2 crystallizes in an orthorhombic space group Pca21 with a = 16.660(5) Å, b = 16.017(5) Å, c = 17.066(5) Å, and Z = 4. The CuLβ macrocycle cation is approximately planar and coordinated from above and below by [ReCl4(ox)]2– units through the bis(bidentate) oxalato ligands. It features an oxalato‐bridged heterometallic ReIV–CuII zigzag chain, the shortest intrachain metal–metal distances are Re···Cu = 5.568(2) and 5.870(2) Å in the direction of the b axis. The crystal structure of 2 consists of dinuclear complex cations [(CuLα)2Cl]3+ with [ReCl4ox]2– and isolated Cl– as counter anions. Cu atoms in CuLα are only fivefold coordinated in a square pyramidal surrounding, and the cations (CuLα)2+ are connected in pairs by chloride. The intramolecular Cu···Cu separation is 4.885(3) Å, the shortest Re···Cu distance is 7.612(3) Å. The magnetic behavior of 1 and 2 has been investigated over the temperature range 1.7–300 K. Compound 1 behaves like a ferrimagnetic CuII‐ReIV dimetallic, one–dimensional chain with intrachain antiferromagnetic coupling. Compound 2 shows weak antiferromagnetic interactions within the CuII–CuII units. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Four New Lead(II) Thiolate Cluster Complexes – Unexpected Products of a Conventional Synthesis
Authors: Eichhöfer Andreas 
Published: April 2005

AbstractThe reaction of Pb(OOCCH3)2·3H2O with 2.1 equiv. of HS‐2,6‐(CH3)2C6H3 in ethanol/water is expected to give [Pb{S‐2,6‐(CH3)2C6H3}2]. However, we obtained an orange powder whose elemental analysis disagrees with that of the expected product and indicates small amounts of oxygen. Layering of concentrated solutions of this orange powder in dry THF with pentane under nitrogen results in the formation of a mixture of three identifiable crystalline compounds, namely [Pb10{S‐2,6‐(CH3)2C6H3}20], [Pb6S{S‐2,6‐(CH3)2C6H3}10(C4H8O)4] and [Pb8O2{S‐2,6‐(CH3)2C6H3}12]. In contrast, fractional crystallization from dilute solutions initially yielded only yellow crystals of [Pb14O6{S‐2,6‐(CH3)2C6H3}16]. Further concentration of the supernatant solution yielded, upon layering with pentane, [Pb6S{S‐2,6‐(CH3)2C6H3}10(C4H8O)4] and [Pb10{S‐2,6‐(CH3)2C6H3}20], which are almost completely separable by controlling the duration of the crystallization step and the amount of condensed pentane. Recrystallization of the crude orange powder under aerobic conditions produces pure [Pb14O6{S‐2,6‐(CH3)2C6H3}16] with a yield five times higher than that under nitrogen. This shows that it is sensitive to oxidation by oxygen in solution. The structures of all four complexes have been determined by single‐crystal X‐ray analysis. The net formed by the six oxygen and twelve lead atoms in the center of [Pb14O6{S‐2,6‐(CH3)2C6H3}16] resembles a small piece of a layer of the solid‐state structure of red PbO. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Novel Methanol‐Containing Oxomolybdate(V) Complexes: Synthesis and Structural Characterisation of Intermediates in the Formation of {Mo2O4}2+ Clusters from [MoOCl4(H2O)]– and [MoOBr4]– Precursors
Authors: Modec Barbara , Brenčič Jurij V. 
Published: April 2005

AbstractA series of oxomolybdate(V) complexes with methanol was prepared by the reaction of (PyH)5[MoOCl4(H2O)]3Cl2 (1) or (PyH)[MoOBr4] (PyH+ = pyridinium cation, C5H5NH+) in methanol. (PyH)2[MoOCl4(MeOH)]Cl (2) is obtained upon substitution of coordinated water for methanol in 1. Small amounts of weak bases such as pyridine or trifluoroacetate promote further substitution chemistry at the labile sites, followed by dimerisation to the well‐known {Mo2O4}2+ core. A dinuclear anion with coordinated methanol can be isolated as its pyridinium salt, (PyH)2[Mo2O4Cl4(MeOH)2], in two crystalline modifications, either as a triclinic (3) or as an orthorhombic polymorph (4). After prolonged reaction times further assembly of dinuclear fragments takes place and tetranuclear [Mo4O8(OMe)2(MeOH)2Cl4]2– is formed. The products of the analogous reactions with (PyH)[MoOBr4] as the starting material depend largely upon the reaction temperature. Dinuclear (PyH)2[Mo2O4Br4(MeOH)2] (5), which crystallises in an orthorhombic unit cell and whose structure is isotypic to that of 4, is obtained only if the reaction takes place at low temperature (5 °C); under ambient conditions (PyH)2[Mo4O8(OMe)2(MeOH)2Br4] (6) is obtained instead. The tetranuclear anion of 6 consists of a commonly adopted assembly of two {Mo2O4}2+ units. The identity of the products was determined by infrared spectroscopy and X‐ray structure analyses. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Structural and Electrochemical Studies of Dimerization and Rotational Isomerization in Multi‐Iron Silicotungstates
Authors: Anderson Travis M. , Cao Rui , Neiwert Wade A. , Hardcastle Kenneth I. , Hill Craig L. , Ammam Malika , Keita Bineta , Nadjo Louis 
Published: April 2005

AbstractA structural and electrochemical investigation of dimerization and Baker–Figgis (rotational) isomerization in the tri‐ferric‐substituted silicotungstates has been undertaken because these phenomena are important in a large number of polyoxometalates. A single‐crystal X‐ray diffraction analysis of K4Na7[(β‐SiFe3W9(OH)3O34)2(OH)3] (β1) has been carried out [a = 12.9709(7) Å, b = 38.720(2) Å, c = 21.4221(12) Å, orthorhombic, Pbcm, R1 = 8.48 %, based on 13809 independent reflections]. The complex is isostructural with [(α‐SiFe3W9(OH)3O34)2(OH)3]11– (α1) except that the edge‐shared W3O13 caps in each [SiFe3W9(OH)3O34]4– unit are rotated by 60°. Electrochemical measurements, performed in a pH 5 acetate buffer, indicate a positive shift in the FeIII‐based peak potential (and no change for the WVI‐based potential) upon going from α1 to its monomeric derivative [(α‐Si(FeOH2)3W9(OH)3O34)]4– (α2) (–0.484 ± 0.005 V and –0.474 ± 0.005 V, respectively). In contrast, the peak potentials of the FeIII‐ and WVI‐based redox processes of β1 are both found at more negative values than its rotational isomer α1. The absolute values of the reduction peak potential differences are 0.022 V for FeIII and 0.162 V for WVI. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)