bluuebunny/crossref_metadata_2025_split huggingface dataset:
Software‐based interventions for low back pain management: A systematic review and meta‐analysis
Authors: Hong Se Jin , Park Jinkyung , Park Soyeon , Eze Bright , Dorsey Susan G. , Starkweather Angela , Kim Kyounghae 
Published: October 2023

AbstractIntroductionUsing software for self‐management interventions can improve health outcomes for individuals with low back pain, but there is a dearth of research to confirm its effectiveness. Additionally, no known research has evaluated the effective elements of software‐based interventions for low back pain self‐management components. This study aimed to synthesize the effectiveness of software‐based interventions to promote self‐management health outcomes among individuals with low back pain.DesignA systematic review and meta‐analysis was conducted.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Statement, relevant studies up to July 2022 were searched via four electronic databases: PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and Web of Science.Results4908 adults with low back pain who participated in 23 studies were included. Software‐based interventions were effective in reducing fear avoidance (mean difference [MD] = −0.95, 95% CI: −1.45 to −0.44), pain catastrophizing (MD = −1.31, 95% CI: −1.84 to −0.78), disability (MD = −8.21, 95% CI: −13.02 to −3.39), and pain intensity (MD = −0.86, 95% CI: −1.17 to −0.55). Specifically, interventions that included an exercise component were more effective in reducing pain and disability. Additionally, cognitive behavioral therapy (CBT) intervention significantly reduced fear avoidance and pain catastrophizing but had no noticeable impact on disability and pain compared to standard treatment. The certainty of the evidence in this review varied from very low to high across outcomes. The heterogeneity of the study results was significant, suggesting that future studies in this area could optimize the design, time points, measures, and outcomes to strengthen the evidence.ConclusionsLow back pain self‐management interventions delivered through software‐based programs effectively reduce pain intensity, disability, fear avoidance, and pain catastrophizing.Clinical RelevanceLow back pain is among the most common reasons for seeking healthcare visits. Combining exercise and counseling through soft‐based programs may effectively address this issue and its associated suffering and disability.
Revisiting the anatomy of the right ventricle in the light of knowledge of its development
Authors: Crucean Adrian , Spicer Diane E. , Tretter Justin T. , Mohun Timothy J. , Anderson Robert H. 
Published: October 2023

AbstractControversies continue regarding several aspects of the anatomy of the morphologically right ventricle. There is disagreement as to whether the ventricle should be assessed in bipartite or tripartite fashion, and the number of leaflets to be found in the tricuspid valve. In particular, there is no agreement as to whether a muscular outlet septum is present in the normally constructed heart, nor how many septal components are to be found during normal development. Resolving these issues is of potential significance to those investigating and treating children with congenitally malformed hearts. With all these issues in mind, we have revisited our own experience in investigating the development and morphology of the normal right ventricle. To assess development, we have examined a large number of datasets, prepared by both standard and episcopic microscopy, from human and murine embryos. In terms of gross anatomy, we have compared dissections of normal autopsied hearts with virtual dissections of datasets prepared using computed tomography. Our developmental and postnatal studies, taken together, confirm that the ventricle is best assessed in tripartite fashion, with the three parts representing its inlet, apical trabecular, and outlet components. The ventricular septum, however, has only muscular and membranous components. The muscular part incorporates a small component derived from the muscularised fused proximal outflow cushions, but this part cannot be distinguished from the much larger part that is incorporated within the free‐standing muscular infundibular sleeve. We confirm that the tricuspid valve itself has three components, which are located inferiorly, septally, and antero‐superiorly.
Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: A randomized, double‐blinded, placebo‐controlled study
Authors: Seong Seol Hwa , Lee Young In , Lee Joohee , Choi Sooyeon , Kim In Ah , Suk Jangmi , Jung Inhee , Baeg Chaemin , Kim Jinhak , Oh Dongchan , Lee Ju Hee 
Published: October 2023

AbstractBackgroundOral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging.AimsA randomized, double‐blinded, placebo‐controlled study was conducted to clinically evaluate the impact of low‐molecular‐weight collagen peptides on the human skin.Patients/MethodsHealthy adult participants (n = 100) were randomly assigned to receive a test product containing low‐molecular‐weight collagen peptides or a placebo. Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks.ResultsCompared with the placebo group, the average skin roughness, maximum of all peak‐to‐valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Moreover, skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.ConclusionsTaken together, these findings suggest that low‐molecular‐weight collagen peptides supplementation can safely ehance human skin wrinkling, hydration, elasticity, and whitening properties.
Impact of caregiver relationship on self‐care in patients with Parkinson's disease: A cross‐sectional study using Riegel's theory of self‐care of chronic illness
Authors: Lee JuHee , Chung Misook Lee , Kim Eunyoung , Yoo Jee‐Hye 
Published: October 2023

AbstractAimsTo explore how the characteristics of patients and caregivers affect self‐care in patients with Parkinson's disease (PD).DesignA multicentre cross‐sectional study.MethodWe followed the STROBE checklist. Parkinson's disease patients aged 50 years and older and their caregivers were recruited from two tertiary hospitals and the Korean Parkinson's Disease Association website. Patient characteristics, including social support, relationship quality with caregivers, self‐care efficacy and self‐care, were analysed. Caregiver characteristics were also evaluated, including caregiving duration, social support, relationship quality with patients, contribution to patients' self‐care efficacy and contribution to patients' self‐care.ResultsThe characteristics of patients and caregivers (103 pairs) were hierarchically regressed into patient self‐care domains (maintenance, monitoring and management). Most patients and caregivers gave a self‐care efficacy and self‐care management rating of moderate. In three regression models, patient self‐care efficacy was positively related to three domains of patient self‐care. Self‐care maintenance decreased as patients' disease duration increased. Self‐care monitoring was positively related to the education level of patients and caregiving duration. Self‐care management showed an inverse relationship with caregiving duration and a positive relationship with caregiver contribution.ConclusionSelf‐care efficacy was important in promoting PD patients' self‐care maintenance, monitoring and management. The contributions of caregivers were also critical in increasing PD patients' self‐care management.Implications for the profession and patient careTo increase patients' self‐care efficacy and self‐care, educational interventions containing information about the disease, symptom management, and problem‐solving should be implemented. Since caregivers are deeply involved in patients' self‐care, educational interventions for caregivers should also be provided.ImpactThis study closed the literature gap by examining the self‐care efficacy and self‐care of Korean PD patients. Findings demonstrated the importance of caregiver roles on patients' self‐care and health.Patient or public contributionTwo tertiary hospitals and the Korean Parkinson's Disease Association assisted during the recruitment process.
Patients' and caregivers' perceptions of the quality of hospital‐at‐home service: A scoping review
Authors: Wang Xiyi , Stewart Carolyne , Lee Geraldine 
Published: October 2023

AbstractAimThis scoping review aims to provide an overview of patients and caregivers perceptions of hospital‐at‐home (HaH) services.BackgroundHaH services provide patients with hospital‐level care at home and are central to integrated healthcare systems. Despite favourable data from individual studies in the literature, in‐depth analysis from patient and caregivers perspectives is lacking. This understanding is essential for the dissemination and scaling of HaH services.DesignThe scoping review was performed using the PRISMA‐ScR checklist and PAGER framework for the findings report and research recommendations.MethodLiterature from PubMed, Web of Science, Ovid, CINAHL, Cochrane and Mednar databases were searched. Relevant studies published between 1st January 2005 and 31st December 2022 were identified. The conceptual model of the development of patient perceptions of quality was used for data extraction and tabulation.ResultsThe review included 24 articles. Expectation attributions were identified as needs, types of service, hospitalisation experiences, family care preferences, social‐demographics and coping skills. From patient's and caregiver's perspectives, HaH was safe, effective and viewed positively. Perceived concerns/barriers and enablers/facilitators were associated with individual, caregiver and system factors, but demonstrated an overall satisfaction in the HaH service.ConclusionHaH provides an excellent service according to patients' and caregivers' perceptions. However, gaps in care were identified such as prioritising patient‐centred care, along with improved multidisciplinary continuity of care and future studies should incorporate these into their research of HaH.Relevance to Clinical PracticePatients' and caregivers' HaH needs should be embedded in the design, development and implementation of HaH services.Patient and Public ContributionNot applicable for the study design of this scoping review.
A model for predicting low progesterone levels on the day of embryo transfer in hormonally prepared vitrified‐warmed embryo transfer cycles: A secondary analysis of a prospective cohort study
Authors: Olgan Safak , Dirican Enver Kerem , Ozsipahi Arif Can , Sakinci Mehmet , Humaidan Peter 
Published: October 2023

AbstractAimTo develop a model that predicts low progesterone (P) levels on the day of embryo transfer (ET) based on patient and cycle characteristics, including serum estradiol (E2) concentration after vaginal administration of micronized E2 for endometrial preparation.MethodsA prospective cohort of 193 patients scheduled for cryopreserved blastocyst transfer during an artificial endometrial preparation cycle, using micronized E2 vaginally for first 4 days (4 mg/day), followed by oral administration (6 mg/day). Blood sampling for E2 was performed prospectively on day‐5 of vaginal administration and analysis was performed retrospectively. On sixth day of P treatment (daily 300 mg of vaginal micronized P tablets), P levels were measured on ET day. Primary outcome measure was serum P levels after vaginal E2 administration.ResultsPatients with low P levels on the day of ET (<7.8 ng/mL, 25th percentile) were heavier (p < 0.001) and exhibited lower day 5 serum E2 levels (p < 0.001) compared with patients with adequate P levels. Multivariate linear regression analysis revealed that weight (p = 0.003) and day 5 E2 levels (p < 0.001) were independently associated with the P levels. The sensitivity, specificity, and positive and negative predictive values (%) were 71.4, 55.6, 35.4, and 85.1 for weight ≥ 65 kg; 71.4, 61.8, 38.9, and 86.4 for day 5 E2 ≤ 1615 pg/mL; 59.2, 83.3, 54.7, and 85.7 for the combination of these two variables; and 82.9, 62.5, 54.7, and 87.0 for the sequential inclusion of these variables, respectively.ConclusionsLow day 5 E2 levels following vaginal administration and high weight are independently associated with low P levels on the day of ET. Predictive performance is enhanced when these variables are considered sequentially or in combination.
Opting out or left out? The gendered determinants of marriage in South Korea
Authors: Chang Paul Y. , Oh Jihye , Kim Young‐Mi 
Published: October 2023

AbstractObjectiveThis study examines the determinants of marriage decline in South Korea, a representative case of the “demographic crisis” sweeping East Asia.BackgroundThe major theories accounting for marriage and family trends are for the most part based on Western cases. A complementing focus on non‐Western societies is likely to identify a more diverse range of processes governing marriage patterns in advanced capitalist societies.MethodThe study draws on the Korean Labor and Income Panel Study (KLIPS) to analyze a sample of 4201 unmarried individuals whose longitudinal data were organized into 55,989 person‐year records. Discrete‐time hazard models incorporating 23 waves of KLIPS data (1998–2020) identify the gendered determinants of marriage.ResultsSocioeconomic resources continue to positively impact men's marriage chances although income, relative to employment status and educational attainment, has become paramount for members of the younger 1980s cohort. Parental wealth, an important precondition for home purchases, also positively impacts the likelihood of marriage for men. Income and parental wealth have become important for women as well but unlike the documented “educational crossover” that has occurred elsewhere, high educational attainment remains negatively associated with marriage probability for Korean women.ConclusionThis study clarifies the scope conditions for arguments about the “shifting economic foundations of marriage,” while foregrounding the enduring legacy of extended‐family resources in strong familism societies. The results also lend empirical leverage to past studies highlighting the clear disincentives for marriage among highly educated women and provide a more comprehensive picture of why underprivileged men are being left out of Korea's marriage market.
Decreased inflammatory profile in oral leukoplakia tissue exposed to cold physical plasma ex vivo
Authors: Seebauer Christian , Freund Eric , Dieke Tobias , Hasse Sybille , Segebarth Maria , Rautenberg Christoph , Metelmann Hans‐Robert , Bekeschus Sander 
Published: October 2023

AbstractBackgroundOral leukoplakia (OL) is an unfavorable oral disease often resistant to therapy. To this end, cold physical plasma technology was explored as a novel therapeutic agent in an experimental setup.MethodsBiopsies with a diameter of 3 mm were obtained from non‐diseased and OL tissues. Subsequently, cold atmospheric pressure plasma (CAP) exposure was performed ex vivo in the laboratory. After 20 h of incubation, biopsies were cryo‐conserved, and tissue sections were quantified for lymphocyte infiltrates, discriminating between naïve and memory cytotoxic and T‐helper cells. In addition, the secretion pattern related to inflammation was investigated in the tissue culture supernatants by quantifying 10 chemokines and cytokines.ResultsIn CAP‐treated OL tissue, significantly decreased overall lymphocyte numbers were observed. In addition, reduced levels were observed when discriminating for the T‐cell subpopulations but did not reach statistical significance. Moreover, CAP treatment significantly reduced levels of C‐X‐C motif chemokine 10 (CXCL10) and granulocyte‐macrophage colony‐stimulating factor in the OL biopsies' supernatants. In idiopathically inflamed tissues, ex vivo CAP exposure reduced T‐cells and CXCL10 as well but also led to markedly increased interleukin‐1β secretion.ConclusionOur findings suggest CAP to have immuno‐modulatory properties, which could be of therapeutic significance in the therapy of OL. Future studies should investigate the efficacy of CAP therapy in vivo in a larger cohort.
Promoting positive development among refugee adolescents
Authors: Abdi Saida , Akinsulure‐Smith Adeyinka M. , Sarkadi Anna , Fazel Mina , Ellis B. Heidi , Gillespie Sarah , Juang Linda P. , Betancourt Theresa S. 
Published: October 2023

AbstractOf the estimated 35.3 million refugees around the world (UNHCR, Figures at a Glance, 2022), approximately 50% are children under the age of 18. Refugee adolescents represent a unique group as they navigate developmental tasks in an unstable and often threatening environment or in resettlement contexts in which they often face marginalization. In addition to physiological, social, and psychological changes that mark adolescence, refugee youth often face traumatic experiences, acculturative stress, discrimination, and a lack of basic resources. In this consensus statement, we examine research on refugee adolescents' developmental tasks, acculturative tasks, and psychological adjustment using Suárez‐Orozco and colleague's integrative risk and resilience model for immigrant‐origin children and youth proposed by Suárez‐Orozco et al. Finally, we discuss recommendations—moving from proximal to more distal contexts.
Converting inventions into innovations to address cancer grand challenges: The role of scientific and digital search intensity
Authors: Ardito Lorenzo , Natalicchio Angelo , Messeni Petruzzelli Antonio , Del Giudice Manlio 
Published: October 2023

AbstractThe present study seeks to shed further light on what favors the conversion of inventions into innovations in for‐profit firms and to advance our understanding of how to tackle cancer grand challenges (CGCs). Specifically, following the literature on knowledge search and recombination, we analyze whether and how cancer‐related inventions developed through an intense adoption of scientific knowledge (scientific search intensity) result in (i) a higher number of approved drugs and (ii) a shorter approval time for new drugs. Notably, while the role of science with regard to technological development has been widely studied, the extent to which science‐based solutions relate to new product introduction, especially in terms of coping with grand challenges such as approved cancer drugs, is less known. Furthermore, considering the digitization of (health) R&D and the role of information and communication technologies (i.e., digital technologies) to address grand challenges, we examine whether and how cancer‐related inventions developed through an intense adoption of digital knowledge (digital search intensity) directly affect the extent and speed of cancer drug approval, as well as whether interaction effects between scientific and digital search intensity exist. We develop hypotheses that we test on a sample of 65,861 cancer‐related patents owned by 139 for‐profit firms, collected from the USPTO Cancer Moonshot Patent Data. These have a priority date between 1990 and 2010, and have led to 1035 approved drugs. Results reveal that scientific search intensity is not associated with the number of different drugs developed from a single cancer‐related invention but is associated with the speed at which the invention leads to a newly approved drug. Digital search intensity appears not to directly affect cancer drug approval, but it lessens the effects of scientific search intensity, thus pointing to a limit of digitization in cancer R&D and innovation processes.
Rural/urban differences in receipt of governmental rental assistance: Relationship to health and disability
Authors: Henning‐Smith Carrie , Swendener Alexis , Rydberg Katie , Lahr Megan , Yam Hawking 
Published: October 2023

AbstractPurposeHousing is essential to health. Governmental rental assistance is one way to increase access to affordable housing, but little is known about how it varies by rural/urban location. This paper seeks to address that gap by examining rural/urban and within‐rural differences in receipt of rental assistance, with particular attention differences by health and disability.MethodsWe used data from the 2021 National Health Interview Survey (n = 28,254) to conduct bivariate analyses to identify significant differences in receipt of rental assistance by rural/urban location. We then conducted logistic regression analyses to generate odds ratios of receiving rental assistance, adjusting for self‐rated health, disability, sociodemographic characteristics, and the US Census region.FindingsWhen limiting the sample to those who rent (20.6% of rural residents and 29.6% of urban residents), rural residents were nearly 5 percentage points more likely to receive rental assistance (13.1% vs 8.2%, P<.001). Rural recipients of rental assistance were more likely to have a disability than urban residents (27.9% vs 20.3%, P<.05) and were more likely to report fair/poor health (41.6% vs 31.4%, P<.05).ConclusionsRural residents are less likely to rent their homes, but, among those who rent, they are more likely to receive governmental rental assistance. This may be reflective of the greater need for rental assistance among rural residents, who were in poorer health and of lower socioeconomic status than urban renters. As housing is essential to good health, policy attention must prioritize addressing a persistent and growing need for affordable housing in rural and urban areas alike.
New insights into infrageneric relationships of Lonicera (Caprifoliaceae) as revealed by nuclear ribosomal DNA cistron data and plastid phylogenomics
Authors: Yang Xu‐Long , Sun Qing‐Hui , Morales‐Briones Diego F. , Landis Jacob B. , Chen Da‐Juan , Wang Hong‐Xin , Wen Jun , Wang Hua‐Feng 
Published: October 2023

AbstractThe discontinuous geographic distribution pattern of plants in the north temperate zone has been a focus of biogeographic research, especially concerning the mechanisms behind the formation of such a pattern and the spatial and temporal evolution of this intermittent distribution pattern. Hypotheses of boreotropical origin, land bridge migration, and out‐of‐Tibet have been proposed to explain the formation of the discontinuous distribution pattern. The distribution of Lonicera shows a typical Europe–Asia–North America discontinuous distribution, which makes for a good case study to investigate the above three hypotheses. In this study, we inferred the phylogeny based on plastid genomes and a nuclear data set with broad taxon sampling, covering 83 species representing two subgenera and four sections. Both nuclear and plastid phylogenetic analyses found section Isika polyphyletic, while sections Nintooa, Isoxylosteum, and Coelxylosteum were monophyletic in subgenus Chamaecerasus. Based on the nuclear and chloroplast phylogeny, we suggest transferring Lonicera maximowiczii and Lonicera tangutica into section Nintooa. Reconstruction of ancestral areas suggests that Lonicera originated in the Qinghai–Tibetan Plateau (QTP) and/or Asia, and subsequently dispersed to other regions. The aridification of the Asian interior may have facilitated the rapid radiation of Lonicera in the region. At the same time, the uplifts of the Tibetan Plateau appear to have triggered the spread and recent rapid diversification of the genus on the QTP and adjacent areas. Overall, our results deepen the understanding of the evolutionary diversification history of Lonicera.