bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive deficits in long‐term survivors of childhood brain tumors: Identification of predictive factors
Authors: Reimers Tonny Solveig , Ehrenfels Susanne , Mortensen Erik Lykke , Schmiegelow Marianne , Sønderkær Signe , Carstensen Henrik , Schmiegelow Kjeld , Müller Jørn 
Published: November 2002

AbstractBackgroundTo describe cognitive function and to evaluate the association between potentially predictive factors and cognitive outcome in an unselected population of survivors of childhood brain tumors.ProcedureWe studied a consecutive sample of 133 patients (76 had received radiotherapy (RT)) who had a brain tumor diagnosed before the age of 15 years and were treated during the period January 1970 through February 1997 in the Eastern part of Denmark. Biologic effective dose of irradiation (BED) was assessed in 71 patients. One hundred twenty‐seven patients were able to cooperate to WISC‐R and WAIS‐R. Multiple regression models were constructed to evaluate relationships between possible risk factors and cognitive outcome.Results and ConclusionsThe mean intelligence (IQ) scores were substantially lower than the expected means of the general population. Younger age at diagnosis, tumor site in cerebral hemisphere, hydrocephalus treated with shunt, and treatment with RT were found to be significant predictors of lower cognitive functions. RT was the most important risk factor for impaired intellectual outcome. The mean observed full scale IQ was 97.1 (SD = 14.3) for the non‐irradiated patients and 78.8 (SD = 14.3) for the irradiated patients (adjusted P < 0.001). Verbal IQ, but not performance and full scale IQ, had a significant negative correlation to BED to the tumor site (P < 0.05). These results can be used to identify subgroups of children who are at increased risk for cognitive deficits allowing early and goal‐directed intervention. Med Pediatr Oncol 2003;40:26–34, © 2003 Wiley‐Liss, Inc.
Stratified morphology of a polypropylene/elastomer blend following channel flow
Authors: Moffitt Matthew , Rharbi Yahya , Chen Warner , Tong Jiang‐Dong , Winnik M. A. , Thurman Derek W. , Oberhauser James P. , Kornfield Julia A. , Ryntz Rose A. 
Published: November 2002

AbstractA thermoplastic olefin blend consisting of isotactic polypropylene (PP) and an ethylene‐butene copolymer (EBR) impact modifier (25 wt % EBR) was subjected to a short, high‐shear pulse within the flow channel of a pressure‐driven microextruder following low‐shear channel filling from a reservoir of the melt. The resulting morphology was examined by laser scanning confocal fluorescence microscopy (LSCFM), with contrast provided by a fluorescent tracer in the EBR minor phase. Shear experiments were performed under isothermal conditions with a known wall shear stress for a specified duration, providing a well‐defined thermal and flow history. Low‐shear channel filling produces small droplets across the central region of the channel and large droplets, consistent with steady‐state shear, in the regions near the channel walls. After cooling the molten blend to a crystallization temperature of 153 °C, a brief interval (5 s ∼ 1/2000 of the quiescent crystallization time) of high shear (wall shear stress: 0.1 MPa) induces rapid, highly oriented crystallization and a stratified morphology. Ex situ LSCFM reveals a “skin” at the channel walls (∼70 μm) in which greatly elongated fiberlike droplets, oriented along the flow direction, are embedded in highly oriented crystalline PP. Further from the walls but directly beside the skin layers are surprising zones in which EBR domains show no deformation or orientation. Several zones of intermediate deformation and orientation at an angle to the flow direction are located closer to the center of the channel. At the center of the channel, EBR droplets are spherical, as expected for channel flow. The various strata are explained by the interplay of droplet deformation, breakup, and coalescence with the shear‐induced crystallization kinetics of the matrix. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 2842–2859, 2002
Poly(ethylene terephthalate) copolymers containing nitroterephthalic units. II. Crystallization and conformational studies
Authors: Kint Darwin P. R. , Martínez De Ilarduya Antxon , Muñoz‐Guerra Sebastián 
Published: November 2002

AbstractThe effect of incorporating a nitro side group into the phenylene units of poly(ethylene terephthalate) (PET) on the conformation and crystallizability of this polyester was evaluated. Random poly(ethylene terephthalate‐co‐nitroterephthalate) (PETNT) copolymers containing 5, 10, and 15 mol % nitroterephthalic units were investigated with reference to PET. All the examined copolymers were semicrystalline and were found to adopt the triclinic crystal structure of PET, with the nitrated units being excluded from the crystallites. Both the crystallinity and crystallization rate of PETNT largely decreased with the content of nitrated units, and the OCH2CH2O trans‐to‐gauche conformational ratio increased with crystallization, attaining comparable values for all the compositions. The conformation and crystallinity of isothermally crystallized PET and PETNT samples could be correlated with the size of the crystallites generated in each case. However, a different crystal perfecting mechanism seemed to operate for PET and for the PETNT copolymers when they were subjected to annealing. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 2759–2771, 2002
Surface ordering in thin films of liquid‐crystalline polymers containing fluorinated and protonated segments: Neutron‐reflectometry study
Authors: Traiphol Rakchart , Smith Dennis W. , Perahia Dvora 
Published: November 2002

AbstractSurface‐induced layering of fluorinated and protonated segments in thin films of a main‐chain liquid‐crystalline polymer, consisting of α‐methylstilbene, bridged by a fluorinated group was revealed by neutron reflectometry. The layering was driven by the difference in surface energy of the fluorinated and protonated segments and by the inherent ordering of the polymer. The lower‐surface‐energy fluorinated segments segregated to the air surface, and the protonated segments segregated to the SiOx layer at the Si substrate. The ordering induced by the interface decayed into the film with a characteristic decay length of about 100 Å. The surface‐induced periodicity ranged from 15 to 20 Å, which is approximately equal to the molecular dimension of the repeating unit on the polymer backbone. The magnitude of segregation increased upon annealing in the liquid‐crystalline temperature range. The segregation was retained upon annealing above the bulk order–disorder transition temperature. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 2817–2824, 2002
‘A Practical Approach to Gender‐Based Violence: A Programme Guide for Health Care Providers and Managers’ developed by the UN Population Fund
Authors: Stevens L 
Published: November 2002

AbstractGender‐based violence (GBV) is a worldwide problem that can have serious physical and psychological consequences. Women need to be assessed for GBV and a logical place to do so would be where women go for health care, reproductive health facilities. The United Nations Population Fund (UNFPA) has developed ‘A Practical Approach to Gender‐Based Violence: A Program Guide for Health Care Providers and Managers’ to assist reproductive health facilities in integrating GBV into their programs. This article briefly describes the project options and the steps that need to be taken in order to implement such projects.
Pregnancy outcomes in urban teenagers
Authors: Chandra P.C. , Schiavello H.J. , Ravi B. , Weinstein A.G. , Hook F.B. 
Published: November 2002

AbstractObjectives: To compare pregnancy outcomes for teenagers with those for older gravidas. Methods: A retrospective case control study was undertaken to compare teenagers who delivered between January 1996 and October 1999 at a public urban hospital with a group of older gravidas. Results: Young pregnant teenagers were more likely to be nulliparous. They weighed less and gained less in pregnancy. More teen pregnancies occurred among Hispanics than other ethnic groups. The younger the teenager, the more likely for her infant to be of low or very low birth weight or growth restricted. There were fewer postmature deliveries, macrosomic fetuses and cesarean deliveries in young gravidas. Perinatal mortality was unaffected by maternal age. Conclusions: This investigation demonstrates that, while pregnancy outcomes in teenagers have improved in recent years relative to historical patterns, teenagers face continuing problems requiring special attention by care givers.
Maize Leaves Turn Away from Neighbors
Authors: Maddonni Gustavo Angel , Otegui Marı́a Elena , Andrieu Bruno , Chelle Michael , Casal Jorge J. 
Published: November 2002

AbstractIn commercial crops, maize (Zea mays) plants are typically grown at a larger distance between rows (70 cm) than within the same row (16–23 cm). This rectangular arrangement creates a heterogeneous environment in which the plants receive higher red light (R) to far-red light (FR) ratios from the interrow spaces. In field crops, the hybrid Dekalb 696 (DK696) showed an increased proportion of leaves toward interrow spaces, whereas the experimental hybrid 980 (Exp980) retained random leaf orientation. Mirrors reflecting FR were placed close to isolated plants to simulate the presence of neighbors in the field. In addition, localized FR was applied to target leaves in a growth chamber. During their expansion, the leaves of DK696 turned away from the low R to FR ratio signals, whereas Exp980 leaves remained unaffected. On the contrary, tillering was reduced and plant height was increased by low R to FR ratios in Exp980 but not in DK696. Isolated plants preconditioned with low R/FR-simulating neighbors in a North-South row showed reduced mutual shading among leaves when the plants were actually grouped in North-South rows. These observations contradict the current view that phytochrome-mediated responses to low R/FR are a relic from wild conditions, detrimental for crop yield.
Regulation of the Distribution of Chlorophyll and Phycobilin-Absorbed Excitation Energy in Cyanobacteria. A Structure-Based Model for the Light State Transition
Authors: McConnell Michael D. , Koop Randy , Vasil'ev Sergej , Bruce Doug 
Published: November 2002

Abstract
The light state transition regulates the distribution of absorbed excitation energy between the two photosystems (PSs) of photosynthesis under varying environmental conditions and/or metabolic demands. In cyanobacteria, there is evidence for the redistribution of energy absorbed by both chlorophyll (Chl) and by phycobilin pigments, and proposed mechanisms differ in the relative involvement of the two pigment types. We assayed changes in the distribution of excitation energy with 77K fluorescence emission spectroscopy determined for excitation of Chl and phycobilin pigments, in both wild-type and state transition-impaired mutant strains ofSynechococcus sp. PCC 7002 andSynechocystis sp. PCC 6803. Action spectra for the redistribution of both Chl and phycobilin pigments were very similar in both wild-type cyanobacteria. Both state transition-impaired mutants showed no redistribution of phycobilin-absorbed excitation energy, but retained changes in Chl-absorbed excitation. Action spectra for the Chl-absorbed changes in excitation in the two mutants were similar to each other and to those observed in the two wild types. Our data show that the redistribution of excitation energy absorbed by Chl is independent of the redistribution of excitation energy absorbed by phycobilin pigments and that both changes are triggered by the same environmental light conditions. We present a model for the state transition in cyanobacteria based on the x-ray structures of PSII, PSI, and allophycocyanin consistent with these results.
The as-1 Promoter Element Is an Oxidative Stress-Responsive Element and Salicylic Acid Activates It via Oxidative Species
Authors: Garretón Virginia , Carpinelli Jorge , Jordana Xavier , Holuigue Loreto 
Published: November 2002

Abstract
The activation sequence-1(as-1)-like element found in the promoter of some glutathione S-transferase (GST) genes, has been previously described as a salicylic acid (SA)- and auxin-responsive element. In this paper, we tested the hypothesis that the activating effect of SA on the as-1 element is mediated by oxidative species. Supporting this hypothesis, our results show that the antioxidants dimethylthiourea (DMTU) and 3-t-butyl-4-hydroxy-anizole (BHA) inhibit the SA-induced transcription of genes controlled by as-1 elements in tobacco (Nicotiana tabacum) plants [i.e. GNT35gene coding for a GST and (as-1)4 /β-glucuronidase(GUS) reporter transgene]. DMTU and BHA also inhibit SA-activated as-1-binding activity in nuclear extracts. Further support for the hypothesis that the as-1 element is activated by oxidative species comes from our result showing that light potentiates the SA-induced activation of the as-1element. Furthermore, methyl viologen, a known oxidative stress inducer in plants, also activates the as-1 element. Increasing H2O2 levels by incubation with H2O2 or with the catalase inhibitor 3-amino-1,2,5-triazole does not activate the (as-1)4 /GUS gene. On the contrary, 3-amino-1,2,5-triazole inhibits the activating effect of SA on the (as-1)4 /GUSgene. These results suggest that oxidative species other than H2O2 mediate the activation of theas-1 element by SA. Our results also suggest that even though the as-1 binding activity is stimulated by oxidative species, this is not sufficient for the transactivation of genes controlled by this element. The complex interplay between SA and reactive oxygen species in the transcriptional activation of defense genes is discussed.
Arabidopsis Brassinosteroid-Insensitivedwarf12Mutants Are Semidominant and Defective in a Glycogen Synthase Kinase 3β-Like Kinase
Authors: Choe Sunghwa , Schmitz Robert J. , Fujioka Shozo , Takatsuto Suguru , Lee Mi-Ok , Yoshida Shigeo , Feldmann Kenneth A. , Tax Frans E. 
Published: November 2002

AbstractMutants defective in the biosynthesis or signaling of brassinosteroids (BRs), plant steroid hormones, display dwarfism. Loss-of-function mutants for the gene encoding the plasma membrane-located BR receptor BRI1 are resistant to exogenous application of BRs, and characterization of this protein has contributed significantly to the understanding of BR signaling. We have isolated two new BR-insensitive mutants (dwarf12-1D and dwf12-2D) after screening Arabidopsis ethyl methanesulfonate mutant populations.dwf12 mutants displayed the characteristic morphology of previously reported BR dwarfs including short stature, short round leaves, infertility, and abnormal de-etiolation. In addition,dwf12 mutants exhibited several unique phenotypes, including severe downward curling of the leaves. Genetic analysis indicates that the two mutations are semidominant in that heterozygous plants show a semidwarf phenotype whose height is intermediate between wild-type and homozygous mutant plants. Unlike BR biosynthetic mutants,dwf12 plants were not rescued by high doses of exogenously applied BRs. Like bri1 mutants,dwf12 plants accumulated castasterone and brassinolide, 43- and 15-fold higher, respectively, providing further evidence that DWF12 is a component of the BR signaling pathway that includes BRI1. Map-based cloning of the DWF12 gene revealed thatDWF12 belongs to a member of the glycogen synthase kinase 3β family. Unlike human glycogen synthase kinase 3β, DWF12 lacks the conserved serine-9 residue in the auto-inhibitory N terminus. In addition, dwf12-1D and dwf12-2D encode changes in consecutive glutamate residues in a highly conserved TREE domain. Together with previous reports that both bin2and ucu1 mutants contain mutations in this TREE domain, this provides evidence that the TREE domain is of critical importance for proper function of DWF12/BIN2/UCU1 in BR signal transduction pathways.
How quickly do children forget events? A systematic study of children's event reports as a function of delay
Authors: Jones Carolyn H. , Pipe Margaret‐Ellen 
Published: November 2002

AbstractSixty‐six children aged between 5 and 7 years participated in the event, ‘Visiting the Pirate’, and were interviewed about it at one of five delays, namely, no delay (immediate interview), or at a 1‐week, 1‐day, 1‐month or 6‐month delay. For open‐ended recall, a significant decrease in the amount of information reported was detected only at the 6‐month delay, although forgetting functions indicated forgetting was most rapid at the shorter delays. Accuracy of open‐ended recall was maintained over all delays. In contrast, in response to specific, leading and misleading questions, accuracy had decreased significantly by the 6‐month delay. The theoretical and practical implications of these findings regarding the effects of delays on children's event reports are discussed. Copyright © 2002 John Wiley & Sons, Ltd.
Estimating national populations: cross‐cultural differences and availability effects
Authors: Brown Norman R. , Cui Xinjie , Gordon Robert D. 
Published: November 2002

AbstractEstimates of national population were studied in two experiments. In Experiment 1, Canadian and Chinese undergraduates rated their knowledge of 112 countries and then estimated the population of each. In Experiment 2, Canadians rated their knowledge of 52 countries and then provided population estimates for these primed countries and for a comparable set of 52 unprimed countries. In Experiment 1, participants from both nations produced estimates that resembled those obtained from Americans in prior studies (Brown and Siegler, 1992, 1993, 1996, 2001). However, there were several reliable cross‐national differences in performance which appear to reflect cross‐cultural differences in task‐relevant naive domain knowledge. In addition, both experiments produced findings consistent with the claim that availability‐based intuitions play an important role in this task. In Experiment 1, cross‐national differences in rated knowledge predicted cross‐national differences in estimated population; in Experiment 2, primed country names elicited larger population estimates than unprimed country names. We conclude by arguing for the general utility of this hybrid approach to real‐world estimation. Copyright © 2002 John Wiley & Sons, Ltd.
Some limitations of functional analyses: Treatment of problem behavior based on the study of alternative responses
Authors: Holden Børge 
Published: November 2002

AbstractFunctional analyses is a viable approach to understanding important causes of problem behavior and to designing interventions. However, functions are not always possible to identify, and results of a functional analysis are sometimes hard to utilize: even when functions are detected, we do not necessarily know exactly how reinforcement of alternative behaviors must be arranged in order to be effective. Consequently, interventions must sometimes be based on additional tools. Research on alternate responses is concerned with variables that influence individual choices among responses, both aberrant and appropriate, and may provide such a tool, but to what extent? Basic and applied research on choice responding are reviewed, and implications for treatment are discussed. Copyright © 2002 John Wiley & Sons, Ltd.
The complex dynamics of technological innovation: a comparison of models using cellular automata
Authors: Leydesdorff Loet 
Published: November 2002

AbstractArthur's (1988, 1989) model of the ‘lock‐in’ predicates the dominance of a single technology, while Kauffman's (1993, 1995) NK‐model investigates the existence of different suboptima in a ‘rugged fitness landscape’. Can the two mechanisms also be offset against each other? Under what conditions can one expect a technological monopoly or an oligopoly to prevail? What can serve as a discursive ground for making comparisons among the results of these sophisticated models? In this study, the two models are first reconstructed using a common language for the coding. The results of the simulations are made visual on the screen by means of a cellular automaton that represents the diffusion of different technologies in terms of different colours. By using a single platform for the interpretation, one can specify the conditions under which the models compete for the explanation. Second, I address the question of how one model interacts with the other. The reduction of the complexity in the coding enables us to focus on the theoretical assumptions. The introduction of a Schumpeterian dynamics of ‘creative destruction’, for example, can be shown to introduce variation in ‘rugged fitness landscapes’. Copyright © 2002 John Wiley & Sons, Ltd.
Mandibular bone invasion by gingival carcinoma on dental CT images as an indicator of cervical lymph node metastasis.
Authors: Ogura I , Kurabayashi T , Amagasa T , Okada N , Sasaki T 
Published: November 2002

OBJECTIVES To evaluate the significance of mandibular bone invasion by gingival carcinoma revealed by reformatted dental CT images as a prognostic indicator of cervical metastasis. METHODS Thirty-two patients with squamous cell carcinoma of the lower gingiva were examined by dental CT. Cervical metastases and survival rates of these patients were analysed in relation to their clinical characteristics, histologic grading based on gingival biopsy, and mandibular bone invasion using reformatted dental CT imaging diagnoses prior to surgery. The dental CT images were classified into four types: Class I, no bone invasion; Class II, invasion confined to the alveolus; Class III, invasion extending between the alveolus and the mandibular canal; and Class IV, invasion beyond the mandibular canal. RESULTS Logistic multivariate regression analysis showed that bony invasion identified on dental CT images was a significant prognostic factor in cervical metastases (P=0.028). The 5-year overall survival rates of Classes I, II, III, and IV were 100% (n=9), 76.2% (n=9), 71.4% (n=7), and 28.6% (n=7), respectively. CONCLUSIONS The evaluation of mandibular bone invasion using dental CT images is useful as a prognostic indicator of cervical metastasis for patients with gingival carcinoma.
Global Changes in Gene Expression in Response to High Light in Arabidopsis,
Authors: Rossel Jan Bart , Wilson Iain W. , Pogson Barry J. 
Published: November 2002

Abstract
A range of environmental conditions can lead to oxidative stress; thus, a prompt and effective response to oxidative stress is crucial for the survival of plants. Microarray and northern-blot analyses were performed toward the identification of the factors and signaling pathways that enable plants to limit oxidative damage caused by exposure to high light (HL). Arabidopsis plants grown under moderate light (100 μmol m−2 s−1) were exposed to HL (1,000 μmol m−2 s−1) for 1 h. The microarray analyses revealed that exposure of Arabidopsis to HL caused an increase in known antioxidant genes, as well as several unknown genes. Some of these unknown genes had homologies to possible regulatory genes and metabolic enzymes. Furthermore, it was found that a range of chaperones were up-regulated in the HL treatment and that this induction was specifically due to the HL stress. The temporal expression under HL and different oxidative stress conditions of a subset of HL-responsive genes was confirmed via northern-blot analysis. Results from the arrays were also compared with publicly available microarray data sets from a range of different stress conditions at the Arabidopsis Functional Genomics Consortium. This cross comparison enabled the identification of genes that may be induced by changes in redox poise. Finally, to determine if the genes that were differentially expressed by HL stress were under similar transcriptional control, we analyzed the promoter sequences for the presence of common motifs.