bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high risk of postoperative periprosthetic femoral fracture in Dorr type C femurs: a retrospective cohort study with ten-year follow-up data and a preliminary monochromatic image analysis
Authors: Li Mingyang , Zeng Yi , Nie Yong , Liao Kai , Pei Fuxing , Yang Jing , Xie Huiqi , Shen Bin 
Published: October 2023

Background:
We applied Anatomique Benoist Girard II (ABG II) stems for total hip arthroplasty (THA) in some Dorr type C femurs as early attempts. Here, we compared the long-term follow-up results between ABG II stems and the “well-performing” Corail stems and their monochromatic images.

Methods:
Among 3214 primary THA records, 43 short ABG II stems and 67 standard-length Corail stems implanted in Dorr type C femurs were eligible and enrolled in this retrospective cohort study, with a mean follow-up of 10.3 years. Revision rates, Harris hip scores, and radiologic signs were compared. Spectral CT scans from a representative sample were obtained, and monochromatic images were reconstructed. A quantitative method was developed to measure the volume of the gap around stems. Patient-specific finite element analysis was conducted to investigate the strains.

Results:
The revision rate of ABG II stems was significantly higher than that of Corail stems (21% vs. 3%, P<0.05). In the monochromatic images, fewer spot-weld signs (2.15 vs. 3.38, P<0.05) and wider gaps around stems (1.64 cm3 vs. 0.13 cm3, P<0.05) were observed on average in the ABG II group. The mean maximum principal strains of the proximal femurs in the ABG II group were close to the yield strains and significantly larger than those in the Corail group (0.0052 vs. 0.0011, P<0.05).

Conclusions:
There was a high risk of postoperative periprosthetic femoral fracture for ABG II stems in Dorr type C femurs. Monochromatic images provided some insight into the failure mechanism.

Level of Evidence:
III
Impact of antibiotic-coated sutures on surgical site infections: a second-order meta-analysis
Authors: Suleiman Adeiza Shuaibu , Abbass Mortada , Hossain Maqsud , Choudhary Priyanka , Bhattacharya Prosun , Islam Md. Aminul 
Published: October 2023

Background:Surgical site infections (SSIs) pose a global challenge, impacting patients and healthcare expenditures. This second-order meta-analysis endeavors to assess the efficacy of antibiotic sutures in averting SSIs by amalgamating data from various meta-studies.Materials and MethodsThis research adhered to the PRISMA 2020 guidelines. The quality and comprehensiveness of the encompassed meta-analyses were assessed through the QUOROM checklist and AMSTAR techniques. The primary study overlap was evaluated via measures such as pairwise intersection heat maps, Corrected Covered Area (CCA), and the citation matrix of evidence. The statistical power at the study level was determined utilizing the meta-meta package. Data synthesis employed random and fixed effects models at a 95% confidence interval. A meta-regression analysis was conducted to explore potential correlations between the CDC classification of surgical site infections, trial types, and the observed effect sizes in the studies.ResultsThis investigation revealed a significant reduction in SSI rates due to antimicrobial-coated sutures, evidenced by a relative risk (RR) of 0.68 (95% CI: 0.59 to 0.76), with a prediction interval of 0.38 to 1.19. The analysis encompassed 18 studies with 22 meta-analyses, demonstrating a median QUOROM score of 13.6 out of 18 and an AMSTAR score of 9.1 out of 11. The presence of moderate heterogeneity was noted (Q=106.611, I square=54.038%), with non-randomized controlled trials (RCTs) exhibiting an RR of 0.56 (95% CI: 0.39 to 0.80), and RCTs displaying an RR of 0.71 (95% CI: 0.63 to 0.81). Subgroup analysis unveiled variable RR reductions for specific surgical procedures.ConclusionAntimicrobial-coated sutures offer a promising approach to mitigating surgical site infection risk (SSIs). However, their efficacy is optimally realized when employed in conjunction with other robust practices.
Interprofessional Team Members' Knowledge and Perceptions of Physical Therapist Education and Practice
Authors: Hintz Emma G. , Tisthammer Alyson P. , North Sara E. 
Published: October 2023

Introduction.
High-quality patient care requires that providers understand and optimize each health care team member's roles and responsibilities.

Review of Literature.
The purpose of this paper was to examine the contemporary knowledge and perceptions of physical therapist (PT) practice and education held by advanced practice interprofessional (IP) team members, including physicians, physician assistants (PAs), and advanced practice registered nurses (APRNs).

Subjects.
Physicians, PAs, and APRNs licensed in the state of Minnesota.

Methods.
Eligible individuals were invited to participate in an online survey assessing understanding of PT practice and education. Descriptive and nonparametric statistical analyses were used to evaluate respondent demographics, practice characteristics, and perceptions and knowledge of PT education and practice.

Results.
Survey responses were analyzed from 442 respondents including 210 APRNs, 182 physicians, 48 PAs, and 2 clinicians of unknown profession. Results demonstrated that most referring providers did not learn about physical therapy during their academic or posttraining education. Those who interacted with PTs more frequently perceived greater benefit for their patients, tended to refer to PTs more often, and demonstrated greater knowledge of PT practice. Poorly understood areas of PT practice and education included PT practice settings, specialties, salary, level of education, and the ability to see patients through direct access.

Discussion and Conclusion.
Multiple areas of poor provider knowledge regarding PT education and practice were identified; many unchanged from the literature in the 1980s. Three main areas of growth were identified from which actionable recommendations are made: increase IP interactions with PTs, address areas of poor understanding of PT education and scope, and maximize shifting perceptions of PTs through education and advocacy. This paper illustrates that PT education and practice are not well understood by referring providers, posing a threat to IP collaboration. A lack of collaboration may hinder patient and system outcomes because of suboptimal provider utilization.
Diagnosis and treatment of coagulopathy using thromboelastography with platelet mapping is associated with decreased risk of pulmonary failure in COVID-19 patients
Authors: Hranjec Tjasa , Mayhew Mackenzie , Rogers Bradley , Solomon Rachele , Hurst Deborah , Estreicher Michael , Augusten Alberto , Nunez Aaron , Green Melissa , Malhotra Shivali , Katz Randy , Rosenthal Andrew , Hennessy Sara , Pepe Paul , Sawyer Robert , Arenas Juan 
Published: October 2023

Introduction
Treatment of coronavirus disease 2019 (COVID-19) patients may require antithrombotic and/or anti-inflammatory medications. We hypothesized that individualized anticoagulant (AC) management, based on diagnosis of coagulopathy using thromboelastography with platelet mapping (TEG-PM), would decrease the frequency of pulmonary failure (PF) requiring mechanical ventilation (MV), mitigate thrombotic and hemorrhagic events, and, in-turn, reduce mortality.

Methods
Hospital-admitted COVID-19 patients, age 18 or older, with escalating oxygen requirements were included. Prospective and supplemental retrospective chart reviews were conducted during a 2-month period. Patients were stratified into two groups based on clinician-administered AC treatment: TEG-PM guided vs. non-TEG guided.

Results
Highly-elevated inflammatory markers (D-dimer, C-reactive protein, ferritin) were associated with poor prognosis but did not distinguish coagulopathic from noncoagulopathic patients. TEG-guided AC treatment was used in 145 patients vs. 227 treated without TEG-PM guidance. When managed by TEG-PM, patients had decreased frequency of PF requiring MV (45/145 [31%] vs. 152/227 [66.9%], P < 0.0001), fewer thrombotic events (2[1.4%] vs. 39[17.2%], P = 0.0019) and fewer hemorrhagic events (6[4.1%] vs. 24[10.7%],P = 0.0240), and had markedly reduced mortality (43[29.7%] vs. 142[62.6%], P < 0.0001). Platelet hyperactivity, indicating the need for antiplatelet medications, was identified in 75% of TEG-PM patients. When adjusted for confounders, empiric, indiscriminate AC treatment (not guided by TEG-PM) was shown to be an associated risk factor for PF requiring MV, while TEG-PM guided management was associated with a protective effect (odds ratio = 0.18, 95% confidence interval 0.08–0.4).

Conclusions
Following COVID-19 diagnosis, AC therapies based on diagnosis of coagulopathy using TEG-PM were associated with significantly less respiratory decompensation, fewer thrombotic and hemorrhagic complications, and improved likelihood of survival.
Bioinformatics analysis of competing endogenous RNA network in decidual natural killer cell from unexplained recurrent spontaneous abortion
Authors: Han Dan , Jia Ningyi 
Published: October 2023

Background:
Decidual natural killer (dNK) cell plays a pivotal role in maintaining pregnancy, especially in the first trimester. Noncoding-RNAs (ncRNAs) are critical regulators of transcription and protein expression. Dysregulation of ncRNAs may be involved in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). However, the role of competing endogenous RNA (ceRNA) based on mRNA–miRNA–lncRNA network in regulating the incidence and progression of URSA remains elusive. The aim of the study is to identify the regulatory network of mRNA–miRNA–LncRNA ceRNA based on bioinformatics analysis in dNK from patients with URSA.

Methods:
Eligible studies were retrieved from PubMed, Embase, and the Gene Expression Omnibus (GEO) databases to identify differentially expressed genes (DEGs), miRNAs and LncRNAs in dNK cells of patients with URSA. Protein–protein interaction (PPI) network was constructed by STRING database and Cytoscape software. Potential regulatory miRNAs and lncRNAs of mRNAs were predicted by miRTarBase and RNA22 and subject to bioinformatics analysis.

Results:
A total of 634 DEGs were screened, including 290 upregulated and 344 downregulated DEGs. Among 207 differentially expressed lncRNAs, 110 lncRNAs were upregulated and 97 were downregulated. According to node degree, 30 hub genes were identified for subsequent research. After drawing the Venn diagram and matching to Cytoscape, an mRNA–miRNA–lncRNA network linked to the pathogenesis of URSA in dNK cells was constructed.

Conclusions:
A novel regulatory network of mRNA–miRNA–lncRNA ceRNA is established in dNK cells from patients with URSA. All RNAs might be used as the biomarkers of the pathogenesis of URSA.
Comparing the effectiveness of single-lumen high-frequency positive pressure ventilation with double-lumen endobronchial tube for the anesthesia management of endoscopic thoracic sympathetic blockade surgery
Authors: Akaslan İlhan , Koc Suna 
Published: October 2023

Objectives:
In this trial, we aimed to compare anesthetic effectiveness of single lumen tube (SLT) for tracheal intubation with high-frequency positive pressure ventilation (HFPPV) versus classic double lumen tube (DLT) for tracheal intubation in endoscopic thoracic sympathetic blockade surgery.

Design:
This was a prospective randomized controlled clinical study.

Setting:
The study was single-centered and conducted in a university hospital.

Participants:
There were 135 endoscopic thoracic sympathetic blockade patients in this study.

Interventions:
The patients were randomly allocated either to DLT (n = 67) or SLT (n = 68) groups. In SLT group, the ventilator setting was kept with frequencies that range from 1 to 1.8 Hz (60–110/min). Data regarding anesthesia duration, surgery duration, difficult intraoperative lung deflation, postoperative atelectasis, postoperative pain, postoperative pneumothorax were recorded and compared. All patients were operated by a single experienced surgeon under general anesthesia provided by the same anesthesia team.

Measurements and main results:
Both groups were age and gender matched. Among all recorded variables, only anesthesia time was found to be close to statistical significance (P = .059, favoring single lumen). All other parameters were found to be similar between groups. (P < .05).

Conclusion:
We reported that DLT and single lumen tracheal intubation were equally effective for lung deflation during surgery, and SLT with HFPPV ventilation mode during endoscopic thoracic sympathetic blockade surgery provided the surgeon with an adequate and clean workspace with shorter onset of anesthesia. We may suggest the HFPPV technique for uncomplicated surgery groups or where sufficient conditions for DLT cannot be provided in the operating room.
Efficacy and safety of Chinese patent medicine compound preparation combined with routine treatment in vitiligo: A Bayesian network meta-analysis
Authors: Wang Jianfeng , Wang Dingding , Si Guomin 
Published: October 2023

Background and purpose:
Treating vitiligo in clinical practice is challenging. Furthermore, oral drugs used in Western medicine have considerable side effects and are unsuitable for long-term treatment. In contrast, Chinese patent medicines (CPMs) are more suitable for long-term oral vitiligo treatment, but medical evidence of their efficacy and safety is lacking. Therefore, in this study, the efficacy and safety of CPMs were evaluated and ranked using a Bayesian network meta-analysis.

Methods:
Seven Chinese and English databases were searched for all relevant articles published up to February 2023. The Bayesian network meta-analysis method was used to analyze the extracted data to evaluate efficacy and safety.

Results:
Six common CPMs for treating vitiligo were selected in our study, and 48 targeted articles and 4446 patients were included. This study showed that Qubai Babuqi tablets (QT) were the most effective for short-term treatment of vitiligo, and that vitiligo capsules or pills (VCP) were the most effective for long-term treatment, together with compound Quchong Banjiuju pills (QP). In terms of surface area under the cumulative ranking curve (SUCRA) values, the order of efficacy of each treatment was as follows: QT (92.18%) > Taohong Qingxue pills (TP) (63.81%) > VCP (55.53%) > QP (50.72%) > Bailing tablets or capsules (BTC) (49.01%) > Baishi pills (BP) (35.69%)>routine therapy (RT) (3.1%) in terms of total effective rate and QT (92.05%) > VCP (71.50%) > QP (66.60%) > TP (42.95%) > BTC (39.66%) > BP (36.60%)>RT (0.6%) in terms of improvement rate. In addition, the safety of the 6 CPMs did not significantly differ in terms of adverse effects. The SUCRA values indicated that QT performed slightly worse than other drugs.

Discussion:
In treating vitiligo, QT is most effective but only suitable for short-term administration owing to its poor safety. VCP and QP could be used as first-choice long-term medications. TP may positively affect repigmentation in patients with limited lesion areas.
Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis
Authors: Batool Aimen , Vaithilingam Rathna Devi , Mohamad Hassan Norul Husna , Safii Syarida Hasnur , Saub Roslan 
Published: October 2023

Background:
Matrix metalloproteinases (MMPs) play a crucial role in the pathogenesis of several chronic diseases including rheumatoid arthritis (RA) and periodontitis (PD). RA patients with periodontitis (RA-PD) are associated with elevated inflammatory burden due to increased production of proinflammatory cytokines. Controlling upregulated MMPs activity in these patients may have potential therapeutic effects. Therefore, aim of this study is to address the focused question: “Do RA subjects with concurrent PD have different levels of MMPs in comparison to RA alone, PD alone and HC subjects?”

Methods:
The systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search from 4 electronic databases (EMBASE, Medline, Web of Science, and Cochrane library) and manual search was performed from inception to July 2023. Quality assessment of each article was done using Newcastle-Ottawa Scale. Meta-analyses derived results were summarized as standardized mean difference (SMD) with 95% confidence intervals.

Results:
A total of 879 articles were extracted. Following screening and full text assessment, 9 studies were included. MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13 were consistently elevated in RA-PD subjects. MMP-8 levels were found to be higher in RA-PD subjects compared with RA alone, PD alone, and HC in 3 studies reporting GCF levels (SMD = 1.2; Z = 2.07; P = .04) and 2 studies reporting serum levels (SMD = 0.87; Z = 4.53; P < .00001).

Conclusion:
RA-PD group showed significantly higher MMP levels in their serum and GCF compared with HC, RA, and PD alone individuals. MMP-8 may serve as a reliable biomarker in the diagnosis and management of RA-PD subjects.
A case report of systemic lupus erythematosus and intestinal tuberculosis with lower gastrointestinal bleeding: A treatment approach utilizing parenteral nutrition
Authors: Zhou Aiping , Wang Ying , Chen Yanling , Zhong Hua , Chen Bo , Tan Chunyu 
Published: October 2023

Rationale:
Limited literatures are available on lower gastrointestinal bleeding in systemic lupus erythematosus (SLE) combined with intestinal tuberculosis. Sharing the treatment experiences of a 26-year-old female patient diagnosed with this complex condition in this report may contribute valuable insights.

Patient concerns:
The patient initially presented with abdominal pain and active gastrointestinal bleeding, leading to admission to the hospital. Over a 2-week period, she experienced persistent bleeding, with daily volumes ranging from 300 mL to 800 mL.

Diagnoses:
Lower gastrointestinal bleeding was diagnosed in this patient with concurrent systemic lupus erythematosus and intestinal tuberculosis.

Interventions:
As her symptoms rapidly progressed, food and water intake had to be completely restricted. The parenteral nutrition was implemented.

Outcomes:
The medical team effectively controlled the bleeding, leading to a notable improvement in the patient’s condition. Consequently, she was able to resume oral intake and was discharged from the hospital.

Lessons:
This case highlights the significance of using parenteral nutrition in the management of lower gastrointestinal bleeding in patients with concurrent systemic lupus erythematosus and intestinal tuberculosis. Close monitoring and collaborative efforts among healthcare professionals are crucial to achieve successful outcomes in similar cases.
Nutritional intervention for the prognosis of nasopharyngeal carcinoma chemoradiotherapy patients: A meta-analysis
Authors: He Ying , Chen Xiaoyu , Yang Tong , Li Yan , Tan Sitao , Liu Xiaoxia 
Published: October 2023

Background:
To conduct a meta-analysis to investigate the effects of different nutritional interventions on various serum nutritional indicators and patients’ prognosis during radiotherapy for nasopharyngeal carcinoma, to assess treatment safety and efficacy.

Methods:
A systematic literature search, mainly randomized controlled trials (RCTs), on the effects of nutritional support on patients undergoing radiotherapy for nasopharyngeal carcinoma was conducted between January 2010 and August 2022 using databases such as China National Knowledge Infrastructure, Wanfang Database, Web of Science, PubMed, Cochrane Library, and Embase. Risk of bias was assessed using the Cochrane Rob2 scale. The meta-analysis was performed using Stata 17.0 software, and the heterogeneity between studies was assessed using the I2 test, and funnel plots were used to qualitatively assess publication bias.

Results:
Overall, 10 RCTs with a total sample size of 879 cases were identified. The meta-analysis results showed that body mass index (BMI) (odds ratio = 0.026, 95% confidence interval[1]: −0.348 to 0.401, P > .05), albumin (standardized mean difference [SMD] = 0.13, 95% CI: −0.127 to 0.387, P > .05), and total protein levels were not significantly different between the nasopharyngeal cancer (NPC) radiotherapy group with nutritional support group (SMD = −0.262, 95% CI: −1.062 to 0.537, P > .05) and the control group; pre-albumin (SMD = 0.256, 95% CI: 0.022–0.491, P = .032), hemoglobin (SMD = 0.436, 95% CI: 0.26–0.612, P < .000), and lymphocyte count (SMD = 1.125, 95% CI: 0.868–1.381, P < .000) were significantly higher in the nutritional intervention group than in the control group.

Conclusion:
Compared with conventional diets, nutritional interventions can improve serum nutritional parameters, nutritional status, treatment tolerance, and prognosis of patients undergoing radiotherapy for nasopharyngeal carcinoma.
Sleep-disordered breathing is related to retinal vein occlusion: A meta-analysis
Authors: Zhang Jun-Tao , Cui Sha , Li Qin , Li Jin-Rong , Zhang Yan-Fang , Zheng Yan-Huang 
Published: October 2023

Background:
Previous studies suggest that sleep-disordered breathing (SDB) may be a potential risk factor of retinal vein occlusion (RVO). We conducted a meta-analysis to systematically explore the relationship between RVO and SDB.

Methods:
Observational studies assessing the relationship between SDB and RVO were retrieved by searches of electronic databases including the PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and Wan Fang databases from database inception to August 9, 2023. In consideration of intra-study heterogeneity, a random-effects model was adopted to combine the results.

Results:
Seven studies (1 retrospective cohort and 6 case-control studies) were included in this meta-analysis, and among 36,628 adults included in those studies, 6452 (17.6%) had SDB. The combined results indicated that SDB was associated with RVO [risk ratio (RR): 1.92, 95% confidence interval (CI): 1.60–2.30, P < .001] with no significant heterogeneity (I
2 = 0%). Subgroup analyses showed consistent relationships between SDB and any RVO (RR: 1.73, 95% CI: 1.13–2.28, P < .001), central RVO (RR: 2.20, 95% CI: 1.57–3.08, P < .001), and branch RVO (RR: 1.85, 95% CI: 1.15–2.99, P = .01). Moreover, the relationship was consistent among patients with mild (RR: 1.82, 95% CI: 1.32–2.53, P < .001), moderate (RR: 2.17, 95% CI: 1.65–2.85, P < .001), and severe SDB (RR: 2.66, 95% CI: 1.96–3.62, P < .001). The association was consistent in studies that adjusted for age and sex (RR: 2.17, 95% CI: 1.50–3.13, P < .001), and in studies with additional adjustment for comorbidities (RR: 1.78, 95% CI: 1.42–2.25, P < .001).

Conclusion:
SDB is associated with RVO in adults.