bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival analysis of palliative radiotherapy in patients with HER-2+ metastatic breast cancer
Authors: Li Xueting , Zhong Xiaorong , Xu Hongyu , Wang Jun , Liu Xianguo , Wang Yang , He Liang , Ma Jiayu , Li Guanghua , Liu Lei 
Published: January 2024

BackgroundWhether radiotherapy can improve the long-term survival of HER-2+ metastatic breast cancer remains unclear. We launched this study to explore the effect of HER-2+ metastatic breast cancer patients through anti-HER-2 targeted therapy + radiotherapy.Methods488 HER-2 + metastatic breast cancer patients who received anti-HER2 targeted ± local radiotherapy from March 2006 to September 2021 were retrospectively collected. Patients were divided into a radiotherapy group (n=207) and a non-radiotherapy group (n=281) based on whether they received radiotherapy or not. 1: 1 propensity matching analysis was used to determine two groups of patients with similar baselines.ResultsBefore matching, the radiotherapy group (n=207) had a median overall survival (mOS) of 51.7 months (48.8-63.8), which was superior to the non-radiotherapy group’s (n=281) mOS of 33.9 months (27.9-39.9) (P &lt; 0.0001). Moreover, the radiotherapy group exhibited better 1-year (94.6% vs 83.9%), 3-year (70.8% vs 45.5%), and 5-year (43.3% vs 25.0%) survival rates compared to the control group. Propensity score matching analysis identified 135 pairs of baseline-matched patients. In the matched groups, the mOS was 57.2 (44.5-69.8) months in the radiotherapy group (n=135) and 34.1 (27.5-40.6) months in the non-radiotherapy group (n=135), showing a statistically significant difference (P &lt; 0.0001). Additionally, the radiotherapy group demonstrated 1-, 3-, and 5-year survival rates of 93.2%, 71.5%, and 46.9%, respectively, while those in the non-radiotherapy group were 89.4%, 45.8%, and 22.2%, respectively. Multivariate Cox analysis revealed that the presence of brain metastasis, liver metastasis, and radiotherapy were identified as independent predictive factors significantly associated with OS.ConclusionIn patients with HER-2 positive metastatic breast cancer, radiotherapy was associated with better survival benefits compared to those who did not receive radiotherapy.
Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy
Authors: Pietruski Paweł , Kosińska-Kaczyńska Katarzyna , Osińska Agnieszka , Zgliczyńska Magdalena , Żebrowska Kinga , Popko Katarzyna , Stelmaszczyk-Emmel Anna 
Published: January 2024

IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity. It may be related to differences in plasma renin-angiotensin-aldosterone components between monochorionic and dichorionic twin pregnancies. The study aimed to analyze the plasma ANG II and ANG 1-7 concentrations in women with monochorionic and dichorionic twin gestation.MethodsA prospective observational study included 79 women between 32 and 34 weeks of gestation with twin pregnancy (31 with monochorionic gestation and 48 with dichorionic gestation). Angiotensin II and angiotensin 1-7 concentrations were measured in the collected blood samples.ResultsNo significant differences were observed in angiotensin II concentrations between the dichorionic and monochorionic group with significantly higher levels of angiotensin 1-7 being observed in the dichorionic group. Angiotensin 1-7 level was higher than angiotensin II in 20 women (64.5%) in the monochorionic group and in 42 women (87.5%, p=0.01) in the dichorionic group. Higher plasma concentrations of angiotensin II and lower concentrations of angiotensin 1-7 were found in 5 women with gestational hypertension and in 3 with preeclampsia compared to normotensive women.DiscussionIt is the first study investigating angiotensin II and angiotensin 1-7 in twin pregnancies regarding chorionicity. Our results showed that plasma angiotensin 1-7 concentration was related to chorionicity, while plasma angiotensin II level was not. In most women with twin gestation angiotensin 1-7 concentration exceeded the concentration of angiotensin II. A switch in the relation between angiotensin II and angiotensin 1-7 was observed in hypertensive pregnant women.
Experimental evaluation of the performance and power output enhancement of a divergent solar chimney power plant by increasing the chimney height
Authors: Prasad Reemal , Ahmed M. Rafiuddin 
Published: January 2024

Solar energy is an attractive renewable energy option for countries located in the tropical region. Harvesting this energy using simple yet innovative technologies such as solar chimney power plants (SCPP) will help the developing countries in meeting their sustainable development goals. In an SCPP, air is heated under a greenhouse collector and the hot air is passed to a chimney, where it drives a turbine while rising up. Research efforts have been directed in the past at improving the performance and power output of an SCPP by varying its geometric parameters. The chimney height of a previously optimized solar chimney power plant, having a divergent chimney, was increased from 4 to 6 m and then to 8 m in this first experimental work of this kind. The temperature variations inside the collector, along the chimney height, the velocity at the turbine section, the power available and the output power of an air turbine, estimated by applying mechanical load, are compared for the three chimney heights. The temperature rise of the air inside the collector was the highest for the 4 m tall SCPP and reduced as the chimney height was increased to 6 and 8 m due to the lower time of stay of air in the collector for greater chimney heights. Along the height of the divergent chimney, the temperature dropped with the maximum drop occurring for the 8 m tall SCPP indicating a lower enthalpy loss at the chimney exit. The air velocity at the turbine section was found to increase with chimney height for given solar insolation/time of the day due to the higher driving force which is the buoyancy effect produced by the hot air. The maximum turbine output power for the 8 m tall SCPP increased by 252% compared to the 4 m tall SCPP indicating that significant improvement in the power output can be achieved by increasing the height of a divergent chimney SCPP. An average power of about 40 kW will be available for a chimney height of 100 m which will be extremely beneficial for the sustainable development of small islands.
Research on the hydration process of solid waste–based cementitious materials and application in roadbase
Authors: Chu Feng , Li Chuanhai , Wu Chuanshan , Wang Yansheng 
Published: January 2024

In order to improve the high-value utilization of industrial solid waste materials, this study prepared a solid waste–based cementitious material (SWCM) using slag, fly ash, desulfurization gypsum, and gangue. The mechanical strength and hydration process of the SWCM and an ordinary Portland cement (OPC) were studied. The results showed that the compressive strength of the SWCM was lower than that of OPC at 3 d, but the compressive strength exceeded that of OPC after 7 d. The isothermal calorimetry results showed that the induction period of the SWCM was five times that of OPC, and the total 4 d exothermic amount of OPC was 1.7 times that of the SWCM. XRD and SEM showed that the hydration products of the SWCM were mainly ettringite (AFt) and hydrated calcium silicate gel (C-S-H). The unconfined compressive strength and dry shrinkage of stabilized macadam were also studied by using the SWCM to replace OPC. The results indicated that the unconfined compressive strength of the SWCM-stabilized macadam is comparable to that of the OPC-stabilized macadam. The dry shrinkage strain was only 79.7% of the OPC-stabilized macadam.
Single‐cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptoms
Authors: Yoon Hyundong , Dean Logan S. , Jiyarom Boonyanudh , Khadka Vedbar S. , Deng Youping , Nerurkar Vivek R. , Chow Dominic C. , Shikuma Cecilia M. , Devendra Gehan , Koh Youngil , Park Juwon 
Published: January 2024

BackgroundAlthough our understanding of the immunopathology and subsequent risk and severity of COVID-19 disease is evolving, a detailed account of immune responses that contribute to the long-term consequences of pulmonary complications in COVID-19 infection remains unclear. Few studies have detailed the immune and cytokine profiles associated with post-acute sequelae of SARS-CoV-2 infection (PASC) with persistent pulmonary symptoms. The dysregulation of the immune system that drives pulmonary sequelae in COVID-19 survivors and PASC sufferers remains largely unknown.ResultsTo characterize the immunological features of pulmonary PASC (PPASC), we performed droplet-based single-cell RNA sequencing (scRNA-seq) to study the transcriptomic profiles of peripheral blood mononuclear cells (PBMCs) from a participant naïve to SARS-CoV-2 (Control) (n=1) and infected with SARS-CoV-2 with chronic pulmonary symptoms (PPASC) (n=2). After integrating scRNA-seq data with a naïve participant from a published dataset, 11 distinct cell populations were identified based on the expression of canonical markers. The proportion of myeloid-lineage cells ([MLCs]; CD14+/CD16+monocytes, and dendritic cells) was increased in PPASC (n=2) compared to controls (n=2). MLCs from PPASC displayed up-regulation of genes associated with pulmonary symptoms/fibrosis, while glycolysis metabolism-related genes were downregulated. Similarly, pathway analysis showed that fibrosis-related (VEGF, WNT, and SMAD) and cell death pathways were up-regulated, but immune pathways were down-regulated in PPASC. Further comparison of PPASC with scRNA-seq data with Severe COVID-19 (n=4) data demonstrated enrichment of fibrotic transcriptional signatures. In PPASC, we observed interactive VEGF ligand-receptor pairs among MLCs, and network modules in CD14+ (cluster 4) and CD16+ (Cluster 5) monocytes displayed a significant enrichment for biological pathways linked to adverse COVID-19 outcomes, fibrosis, and angiogenesis. Further analysis revealed a distinct metabolic alteration in MLCs with a down-regulation of glycolysis/gluconeogenesis in PPASC compared to SARS-CoV-2 naïve samples.ConclusionAnalysis of a small scRNA-seq dataset demonstrated alterations in the immune response and cellular landscape in PPASC. The presence of elevated MLC levels and their corresponding gene signatures associated with fibrosis, immune response suppression, and altered metabolic states suggests a potential role in PPASC development.
Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders
Authors: Rajmohan Ravi , Baveja Shivali , Nguyen Dai , Shah Eshita , Sy Michael , Attaripour Sanaz , Swope David 
Published: January 2024

BackgroundGlutamic acid decarboxylase antibody-spectrum disorders (GAD-SDs) include a group of autoimmune neurological diseases associated with neuronal excitability, most noticeably stiff person syndrome. Immune modulators are the mainstay of treatment, but a significant number of patients remain refractory.MethodsWe present our single-center experience of eight cases of GAD-SD, two of which were refractory to immune modulatory treatments.ResultsOf the two cases that were refractory to immunomodulation, one showed significant improvement with bilateral globus pallidus interna deep brain stimulation (GPi DBS) placement, and the other showed significant improvement with autologous hematopoietic stem cell transplant (aHSCT).DiscussionTo our knowledge, this is the first instance of GPi DBS placement being noted to improve GAD-SD movements.
ANCA-associated glomerulonephritis and lupus nephritis following COVID-19 vaccination: a case report and literature review
Authors: Campos Marcos Adriano Garcia , Valois Tiago de Oliveira , Magalhães Luís Eduardo , Vasques Lucas Fernandes , de Medeiros Rafael Goulart , Costa Denise Maria do Nascimento , Salgado Filho Natalino , Nogueira Raquel Moraes da Rocha , Neves Precil Diego Miranda de Menezes , Silva Gyl Eanes Barros 
Published: January 2024

With the coverage of COVID-19 vaccination, it has been possible to observe the potential side effects of SARS-CoV-2 vaccines, with the most common ones being fever, myalgia, headache, and fatigue. However, an association has been observed between new and recurrent kidney injuries, mainly glomerulonephritis and lupus nephritis associated with ANCA, with the Pfizer-BioNTech, Moderna, Sinovac, and AstraZeneca vaccines, although the relationship between them is not clear. We report a case of ANCA-related vasculitis and lupus glomerulonephritis after the second dose of the AstraZeneca vaccine. The elderly patient presented significant worsening of kidney function after immunosuppression and complications after a new onset COVID-19 infection that led to death. We provide a literature review about kidney damage related to ANCA vasculitis after COVID-19 vaccine, aiming for a better understanding of the pathophysiological mechanism of kidney injury, its presentation, and treatment.
A Mendelian randomization study of the effect of serum 25-hydroxyvitamin D levels on autoimmune thyroid disease
Authors: Yu Yunfeng , Yang Xinyu , Wu Jingyi , Shangguan Xueli , Bai Siyang , Yu Rong 
Published: January 2024

ObjectiveThe influence of vitamin D on autoimmune thyroid disease (AITD) remains a subject of ongoing debate. This study employs Mendelian randomization (MR) to investigate the causal correlations of serum 25-hydroxyvitamin D (25[OH]D) levels with autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves disease (GD).MethodsData on single nucleotide polymorphisms related to serum 25(OH)D levels, AIT, AIH, and GD were sourced from UK Biobank and FinnGen. Inverse variance weighted, MR-Egger, and weighted median were employed to test the exposure-outcome causal relationship. Assessments of horizontal pleiotropy, heterogeneity, and stability were performed using the MR-Egger intercept, Cochran’s Q test, and leave-one-out sensitivity analysis, respectively.ResultsThe results of MR analysis showed increased serum 25(OH)D levels was associated with a reduced risk of AIT (OR 0.499, 95% CI 0.289 to 0.860, p = 0.012) but not causal associated with AIH (OR 0.935, 95% CI 0.695 to 1.256, p = 0.654) and GD (OR 0.813, 95% CI 0.635 to 1.040, p = 0.100). Intercept analysis showed no horizontal pleiotropy (p &gt; 0.05), and Cochran’s Q test showed no heterogeneity (p &gt; 0.05). Sensitivity analysis suggested that these results were robust.ConclusionAn increased serum 25(OH)D level is associated with AIT risk reduction but unrelated to AIH and GD. This finding suggests that vitamin D supplementation can be valuable for preventing and treating AIT.
Willingness to institutionalize a relative with dementia: a web-platform assessment with the Portuguese adapted version of the Desire-to-Institutionalize Scale
Authors: Teles Soraia , Napolskij Milaydis Sosa , Ribeiro Oscar , Alves Sara , Freitas Alberto , Ferreira Ana , Paúl Constança 
Published: January 2024

IntroductionOlder persons with dementia (PwD) are more likely to be institutionalized than their counterparts without dementia. The caregiver’s desire to institutionalize has been suggested as the most important predictor of actual institutionalization. This cross-sectional study aimed to culturally adapt the Desire to Institutionalize Scale (DIS) to a country with a high prevalence of dementia (Portugal) and examine its psychometric properties.MethodsThe reliability, structural validity, and criterion validity of the DIS-PT were assessed by applying the scale using a remote measurement web platform. A sample of 105 dementia caregivers completed the DIS-PT and several psychosocial measures, including caregiver burden, anxiety, depression, quality of life, PwD functional independence, and neuropsychiatric symptoms.ResultsThe DIS-PT demonstrated good structural validity, with one factor explaining 75% of the total variance. The internal consistency of the scale was high (α = 0.802). Most caregivers (65.7%) endorsed at least one item on the DIS-PT (Mdn 2). The caregiver’s desire to institutionalize was significantly associated with the caregiver, care recipient, and contextual variables previously known to affect institutional placement. These included the caregivers’ occupational status, perceived burden, anxiety (but not depression), physical and psychological quality of life, care recipient education, severity of neuropsychiatric symptoms, and cohabitation with the caregiver.DiscussionThis study offers preliminary support for the psychometric quality of the DIS-PT. The scale has practical applications in the early identification of caregivers considering nursing home placement, providing room for intervention in modifiable risk factors that may otherwise lead to the institutionalization of PwD. Remote measurement tools may hold value in assessing caregiving dyads non-intrusively and inexpensively.
The ménage à trois of healthcare: the actors in after-AI era under patient consent
Authors: Saccà Riccardo , Turrini Rachele , Ausania Francesco , Turrina Stefania , De Leo Domenico 
Published: January 2024

IntroductionArtificial intelligence has become an increasingly powerful technological instrument in recent years, revolutionizing many sectors, including public health. Its use in this field will inevitably change clinical practice, the patient-caregiver relationship and the concept of the diagnosis and treatment pathway, affecting the balance between the patient’s right to self-determination and health, and thus leading to an evolution of the concept of informed consent. The aim was to characterize the guidelines for the use of artificial intelligence, its areas of application and the relevant legislation, to propose guiding principles for the design of optimal informed consent for its use.Materials and methodsA classic review by keywords on the main search engines was conducted. An analysis of the guidelines and regulations issued by scientific authorities and legal bodies on the use of artificial intelligence in public health was carried out.ResultsThe current areas of application of this technology were highlighted, divided into sectors, its impact on them, as well as a summary of current guidelines and legislation.DiscussionThe ethical implications of artificial intelligence in the health care system were assessed, particularly regarding the therapeutic alliance between doctor and patient, and the balance between the right to self-determination and health. Finally, given the evolution of informed consent in relation to the use of this new technology, seven guiding principles were proposed to guarantee the right to the most informed consent or dissent.
MDSVDNV: predicting microbe–drug associations by singular value decomposition and Node2vec
Authors: Tan Huilin , Zhang Zhen , Liu Xin , Chen Yiming , Yang Zinuo , Wang Lei 
Published: January 2024

IntroductionRecent researches have demonstrated that microbes are crucial for the growth and development of the human body, the movement of nutrients, and human health. Diseases may arise as a result of disruptions and imbalances in the microbiome. The pathological investigation of associated diseases and the advancement of clinical medicine can both benefit from the identification of drug-associated microbes.MethodsIn this article, we proposed a new prediction model called MDSVDNV to infer potential microbe-drug associations, in which the Node2vec network embedding approach and the singular value decomposition (SVD) matrix decomposition method were first adopted to produce linear and non-linear representations of microbe interactions.Results and discussionCompared with state-of-the-art competitive methods, intensive experimental results demonstrated that MDSVDNV could achieve the best AUC value of 98.51% under a 5-fold CV, which indicated that MDSVDNV outperformed existing competing models and may be an effective method for discovering latent microbe–drug associations in the future.
Bazi Bushen capsule improves the deterioration of the intestinal barrier function by inhibiting NLRP3 inflammasome-mediated pyroptosis through microbiota-gut-brain axis
Authors: Zhang Shixiong , Li Mengnan , Chang Liping , Mao Xinjing , Jiang Yuning , Shen Xiaogang , Niu Kunxu , Lu Xuan , Zhang Runtao , Song Yahui , Ma Kun , Li Hongrong , Wei Cong , Hou Yunlong , Wu Yiling 
Published: January 2024

PurposeThe senescence-accelerated prone mouse 8 (SAMP8) is a widely used model for accelerating aging, especially in central aging. Mounting evidence indicates that the microbiota-gut-brain axis may be involved in the pathogenesis and progression of central aging-related diseases. This study aims to investigate whether Bazi Bushen capsule (BZBS) attenuates the deterioration of the intestinal function in the central aging animal model.MethodsIn our study, the SAMP8 mice were randomly divided into the model group, the BZ-low group (0.5 g/kg/d BZBS), the BZ-high group (1 g/kg/d BZBS) and the RAPA group (2 mg/kg/d rapamycin). Age-matched SAMR1 mice were used as the control group. Next, cognitive function was detected through Nissl staining and two-photon microscopy. The gut microbiota composition of fecal samples was analyzed by 16S rRNA gene sequencing. The Ileum tissue morphology was observed by hematoxylin and eosin staining, and the intestinal barrier function was observed by immunofluorescence. The expression of senescence-associated secretory phenotype (SASP) factors, including P53, TNF-α, NF-κB, IL-4, IL-6, and IL-10 was measured by real-time quantitative PCR. Macrophage infiltration and the proliferation and differentiation of intestinal cells were assessed by immunohistochemistry. We also detected the inflammasome and pyroptosis levels in ileum tissue by western blotting.ResultsBZBS improved the cognitive function and neuronal density of SAMP8 mice. BZBS also restored the intestinal villus structure and barrier function, which were damaged in SAMP8 mice. BZBS reduced the expression of SASP factors and the infiltration of macrophages in the ileum tissues, indicating a lower level of inflammation. BZBS enhanced the proliferation and differentiation of intestinal cells, which are essential for maintaining intestinal homeostasis. BZBS modulated the gut microbiota composition, by which BZBS inhibited the activation of inflammasomes and pyroptosis in the intestine.ConclusionBZBS could restore the dysbiosis of the gut microbiota and prevent the deterioration of intestinal barrier function by inhibiting NLRP3 inflammasome-mediated pyroptosis. These results suggested that BZBS attenuated the cognitive aging of SAMP8 mice, at least partially, by targeting the microbiota-gut-brain axis.