bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinspired Bioinks for the Fabrication of Chemomechanically Relevant Standalone Disease Models of Hepatic Steatosis
Authors: Guagliano Giuseppe , Volpini Cristina , Sardelli Lorenzo , Briatico Vangosa Francesco , Visai Livia , Petrini Paola 
Published: February 2024

AbstractHepatotoxicity‐related issues are poorly predicted during preclinical experimentation, as its relevance is limited by the inadequacy to screen all the non‐physiological subclasses of the population. These pitfalls can be solved by implementing complex in vitro models of hepatic physiology and pathologies in the preclinical phase. To produce these platforms, extrusion‐based bioprinting is focused on, since it allows to manufacture tridimensional cell‐laden constructs with controlled geometries, in a high‐throughput manner. Different bioinks, whose formulation is tailored to mimic the chemomechanical environment of hepatic steatosis, the most prevalent hepatic disorder worldwide, are proposed. Internally crosslinked alginate hydrogels are chosen as structural components of the inks. Their viscoelastic properties (G′ = 512–730 Pa and G″ = 94–276 Pa, depending on frequency) are tuned to mimic those of steatotic liver tissue. Porcine hepatic ECM is introduced as a relevant biochemical cue. Sodium oleate is added to recall the accumulation of lipids in the tissue. Downstream analyses on 14‐layered bioprinted structures cultured for 10 days reveal the establishment of steatotic‐like features (intracellular lipid vesicles, viability decrease up to ≈50%) without needing external conditionings. The presented bioinks are thus suitable to fabricate complex models of hepatic steatosis to be implemented in a high‐throughput experimental frame.
All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair
Authors: Li Weikun , Liu Zonghao , Tan Xin , Yang Ning , Liang Yanling , Feng Diyi , Li Han , Yuan Renqiang , Zhang Qianli , Liu Ling , Ge Liqin 
Published: February 2024

AbstractDiabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, a novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining the multifunctional microneedle carried tannin@ZnO microparticles (TZ@mMN) with the self‐powered triboelectric nanogenerator (TENG). In addition to the delivery of tannin and Zn2+, TZ@mMN also effectively conducts electrical stimulation (ES) to infected diabetic wounds. As a self‐powered device, the TENG can convert biomechanical motion into exogenous ES to accelerate the infected diabetic wound healing. In vitro experiment demonstrated that TZ@mMN shows excellent conductive, high antioxidant ability, and effective antibacterial properties against both Staphylococcus aureus and Escherichia coli (>99% antibacterial rates). Besides, the TZ@mMN‐TENG can effectively promote cell proliferation and migration. In the diabetic rat full‐thickness skin wound model infected with Staphylococcus aureus, the TZ@mMN‐TENG can eliminate bacteria, accelerate epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α and IL‐6 expression), and promote angiogenesis (higher CD31 and VEGF expression) to accelerate infected wound repair. Overall, the TZ@mMN‐TENG provides a promising strategy for clinical application in diabetic wound repair.
Engineering and Targeting Neutrophils for Cancer Therapy
Authors: Zhang Jiahui , Gu Jianmei , Wang Xu , Ji Cheng , Yu Dan , Wang Maoye , Pan Jianming , Santos Hélder A. , Zhang Hongbo , Zhang Xu 
Published: February 2024

AbstractNeutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti‐tumor properties while N2 neutrophils display tumor‐supportive and immune‐suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re‐polarization of tumor‐promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation‐responsive and physical barrier‐crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.
Efficient Thermal Management with Selective Metamaterial Absorber for Boosting Photothermal CO2 Hydrogenation under Sunlight
Authors: Liu Shengkun , Wang Xin , Chen Yihong , Li Yaping , Wei Yu , Shao Tianyi , Ma Jun , Jiang Wenbin , Xu Junchi , Dong Yueyue , Wang Chengming , Liu Hengjie , Gao Chao , Xiong Yujie 
Published: February 2024

AbstractPhotothermal catalytic CO2 hydrogenation is a prospective strategy to simultaneously reduce CO2 emission and generate value‐added fuels. However, the demand of extremely intense light hinders its development in practical applications. Herein, this work reports the novel design of Ni‐based selective metamaterial absorber and employs it as the photothermal catalyst for CO2 hydrogenation. The selective absorption property reduces the heat loss caused by radiation while possessing effectively solar absorption, thus substantially increasing local photothermal temperature. Notably, the enhancement of local electric field by plasmon resonance promotes the adsorption and activation of reactants. Moreover, benefiting from the ingenious morphology that Ni nanoparticles (NPs) are encapsulated by SiO2 matrix through co‐sputtering, the greatly improved dispersion of Ni NPs enables enhancing the contact with reaction gas and preventing the agglomeration. Consequently, the catalyst exhibits an unprecedented CO2 conversion rate of 516.9 mmol gcat−1 h−1 under 0.8 W cm−2 irradiation, with near 90% CO selectivity and high stability. Significantly, this designed photothermal catalyst demonstrates the great potential in practical applications under sunlight. This work provides new sights for designing high‐performance photothermal catalysts by thermal management.
Quantifying Dielectric Material Charge Trapping and De‐Trapping Ability Via Ultra‐Fast Charge Self‐Injection Technique
Authors: Xu Shuyan , Wang Jian , Wu Huiyuan , Zhao Qionghua , Li Gui , Fu Shaoke , Shan Chuncai , Li Kaixian , Zhang Zhiyi , Hu Chenguo 
Published: February 2024

AbstractRecently, utilizing the air breakdown effect in the charge excitation strategy proves as an efficient charge injection technique to increase the surface charge density of dielectric polymers for triboelectric nanogenerators (TENGs). However, quantitative characterization of the ability of dielectric polymers to trap reverse charges and the effect on the startup time of secondary self‐charge excitation (SSCE) are essential for extensive applications. Here, an ultra‐fast charge self‐injection technique based on a self‐charge excitation strategy is proposed, and a standard method to quantify the charge trapping and de‐trapping abilities of 23 traditional tribo‐materials is introduced. Further, the relationship among the distribution of dielectric intrinsic deep, shallow trap states, and transportation of trapped charges is systematically analyzed in this article. It shows that the de‐trapping rate of charges directly determines the reactivation and failure of SSCE. Last, independent of TENG contact efficiency, an ultra‐high charge density of 2.67 mC m−2 and an ultra‐fast startup time of SSCE are obtained using a 15 µm poly(vinylidene fluoride‐trifluoroethylene) film, breaking the historical record for material modification. As a standard for material selection, this work quantifies the charge trapping and de‐trapping ability of the triboelectric dielectric series and provides insights for understanding the charge transport in dielectrics.
Establishing Pinhole Deposition Mode of Zn via Scalable Monolayer Graphene Film
Authors: Zou Yuhan , Wu Yuzhu , Wei Wenze , Qiao Changpeng , Lu Miaoyu , Su Yiwen , Guo Wenyi , Yang Xianzhong , Song Yuqing , Tian Meng , Dou Shixue , Liu Zhongfan , Sun Jingyu 
Published: February 2024

AbstractThe uneven texture evolution of Zn during electrodeposition would adversely impact upon the lifespan of aqueous Zn metal batteries. To address this issue, tremendous endeavors are made to induce Zn(002) orientational deposition employing graphene and its derivatives. Nevertheless, the effect of prototype graphene film over Zn deposition behavior has garnered less attention. Here, it is attempted to solve such a puzzle via utilizing transferred high‐quality graphene film with controllable layer numbers in a scalable manner on a Zn foil. The multilayer graphene fails to facilitate a Zn epitaxial deposition, whereas the monolayer film with slight breakages steers a unique pinhole deposition mode. In‐depth electrochemical measurements and theoretical simulations discover that the transferred graphene film not only acts as an armor to inhibit side reactions but also serves as a buffer layer to homogenize initial Zn nucleation and decrease Zn migration barrier, accordingly enabling a smooth deposition layer with closely stacked polycrystalline domains. As a result, both assembled symmetric and full cells manage to deliver satisfactory electrochemical performances. This study proposes a concept of “pinhole deposition” to dictate Zn electrodeposition and broadens the horizons of graphene‐modified Zn anodes.
Tandem Hydrogen‐Borrowing Dehydrogenative Coupling and Hydrodefluorination
Authors: Sidhu Baldeep K. , Mondal Rajarshi , Herbert David E. 
Published: February 2024

AbstractDehydrogenative coupling (DC) is an attractive approach to constructing new C−N bonds using alcohols as electrophiles. In ‘hydrogen‐borrowing’ variants of DC, the H2 liberated can be used to re‐hydrogenate unsaturated intermediates to produce saturated products. Here, we show how so‐generated H2 can also be used to replace fluorine atoms with hydrogens in CF3 groups in a tandem dehydrogenative coupling/hydrodefluorination process.
Machine Learning Design of Perovskite Catalytic Properties
Authors: Jacobs Ryan , Liu Jian , Abernathy Harry , Morgan Dane 
Published: February 2024

AbstractDiscovering new materials that efficiently catalyze the oxygen reduction and evolution reactions is critical for facilitating the widespread adoption of solid oxide fuel cell and electrolyzer (SOFC/SOEC) technologies. Here, machine learning (ML) models are developed to predict perovskite catalytic properties critical for SOFC/SOEC applications, including oxygen surface exchange, oxygen diffusivity, and area specific resistance (ASR). The models are based on trivial‐to‐calculate elemental features and are more accurate and dramatically faster than the best models based on ab initio‐derived features, potentially eliminating the need for ab initio calculations in descriptor‐based screening. The model of ASR enables temperature‐dependent predictions, has well calibrated uncertainty estimates and online accessibility. Use of temporal cross‐validation reveals the model to be effective at discovering new promising materials prior to their initial discovery, demonstrating the model can make meaningful predictions. Using the SHapley Additive ExPlanations (SHAP) approach, detailed discussion of different approaches of model featurization is provided for ML property prediction. Finally, the model is used to screen more than 19 million perovskites to develop a list of promising cheap, earth‐abundant, stable, and high performing materials, and find some top materials contain mixtures of less‐explored elements (e.g., K, Bi, Y, Ni, Cu) worth exploring in more detail.
Acreage and farm investments decisions amidst uncertainty: A case study of rural India
Authors: Ajewole Kayode , Mishra Ashok K. , Villacis Alexis 
Published: February 2024

AbstractThis study provides evidence‐based information on the impact of the pandemic lockdown and other COVID‐19‐related policies on Indian rural households' decisions on‐farm investments and operations (planting and borrowing decisions). The study uses the World Bank's (2021) high‐frequency rural household‐level survey across six states of India for the 2020 Kharif crop season. Our analyses also show that farm households exhibit differences in their perception of the pandemic's impact on their farming operations. In terms of input cost, farm households exhibited heterogeneous reactions to input costs like fertilizer during the early part of the pandemic. Our results also show that government incentives in the form of cash transfers do not significantly impact households' farm operations decisions (including loan acquisitions). [EconLit Citations: C36, D19, Q12, R20].
Estimating potential gains from agricultural cooperative mergers
Authors: Ofori Eric , Yeager Elizabeth A. , Briggeman Brian C. 
Published: February 2024

AbstractThis study uses an ex ante data envelopment analysis approach to examine potential gains that US agricultural cooperatives may accrue from mergers. Empirical estimations utilize data from CoBank, a lender to cooperatives, consisting of 749 midwestern agricultural cooperative observations from 2011 to 2015. Potential overall merger effects are decomposed into learning effects, scope effects, and scale effects. Findings show that less other unique merger costs such as legal fees, there are significant overall potential gains in profits from mergers. Relatively smaller merged cooperatives will accrue more gains in profits compared with their larger counterparts [EconLit Citations: Q13, D20, G34].
Can health trump taste? Implicit and explicit attitudes toward sugar‐reduction claims and their differentiated impact on purchase intention for cereals
Authors: Neubig Christina M. , Staudigel Matthias , Roosen Jutta 
Published: February 2024

AbstractThis study investigates the implicit and explicit health–taste tradeoffs that consumers make in response to sugar‐reduction claims on chocolate cereals. We collect implicit measures through an Implicit Association Test, explicit perceptions of health and taste properties, and statements regarding product liking and purchase intention through a questionnaire. Based on a path analysis, we assess the relative strength of the indirect effects of sugar‐reduction claims mediated by health and taste perceptions, as well as the direct effects on purchase intention. The results indicate that sugar‐reduction claims decrease taste perceptions, increase health perceptions, and have only minor negative effects on product liking, but increase purchase intentions. Most participants show an implicit “unhealthy = tasty” intuition, which can be offset by moderate to high health consciousness. The implications for marketing and policymakers are twofold. First, our study shows that sugar‐reduction claims are effective in addressing the original target group of health‐conscious consumers. Second, our results suggest that the health–taste tradeoff is not prohibitively detrimental to purchase intentions among less health‐conscious consumers. Potential instruments to increase the market share in this segment are discussed [EconLit Citations: I18, D12, D83].
Flash Joule‐heating synthesis of MoO2 nanocatalysts in graphene aerogel for deep catalytic oxidative desulfurization
Authors: Xia Dong , Li Heng , Huang Peng , Zhou Wenyu , Kulak Alexander , Luo Ningjing , Li Qun 
Published: February 2024

AbstractUltra‐high‐temperature flash Joule‐heating of organometallic precursor‐embedded reduced graphene oxide (rGO) aerogel represents a highly efficient approach for the ultrafast production of nanocatalysts, while such a methodology has been scarcely applied to 3D nanocarbon‐based aerogel monoliths. Herein, we demonstrate the rapid synthesis of MoO2 nanoparticles within the aerogel matrix via a 1‐s high‐temperature flash Joule‐heating process (~1700°C), resulting in the formation of the hybrid MoO2@rGO aerogel with uniformly distributed nanoparticles. Nitrogen adsorption/desorption analysis indicates discernible internal microstructural disparities attributed to the additional 1‐s flash‐heating and the substantial generation of MoO2 nanoparticles. This aerogel exhibits exceptional catalytic functionality, achieving up to 99.8% efficiency in converting dibenzothiophene to dibenzothiophene sulfone. Density functional theory calculations provide insights into the catalytic mechanism, revealing that the Mo center shows accumulated electron density contributed from the electron‐rich graphene substrate. This electron density enhancement significantly enhances the catalytic activity, enabling deep desulfurization. The proposed flash nanocatalyst synthesis approach presented here can be extended to fabricate multimetallic nanocatalysts and high‐entropy alloys within the cylindrical aerogel entity, exhibiting great potential for applications in industry‐relevant flow chemistry, electrochemistry, industrial catalysis, and beyond.
Advances towards genome‐based acute myeloid leukemia classification: A comparative analysis of WHO‐HAEM4R, WHO‐HAEM5, and International Consensus Classification
Authors: Chen Xue , Yuan Lili , Zhang Yang , Wang Fang , Ma Xiaoli , Fang Jiancheng , Cao Panxiang , Liu Yijun , Liu Zhixiu , Liu Ming , Chen Jiaqi , Zhou Xiaosu , Liu Mingyue , Jin David , Wang Tong , Lu Peihua , Liu Hongxing 
Published: February 2024

AbstractTwo recent guidelines, the 5th edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO‐HAEM5) and the International Consensus Classification (ICC), were published to refine the diagnostic criteria of acute myeloid leukemia (AML). They both consider genomic features more extensively and expand molecularly defined AML subtypes. In this study, we compared the classifications of 1135 AML cases under both criteria. According to WHO‐HAEM5 and ICC, the integration of whole transcriptome sequencing, targeted gene mutation screening, and conventional cytogenetic analysis identified defining genetic abnormalities in 89% and 90% of AML patients, respectively. The classifications displayed discrepancies in 16% of AML cases after being classified using the two guidelines, respectively. Both new criteria significantly reduce the number of cases defined by morphology and differentiation. However, their clinical implementation heavily relies on comprehensive and sophisticated genomic analysis, including genome and transcriptome levels, alongside the assessment of pathogenetic somatic and germline variations. Discrepancies between WHO‐HAEM5 and ICC, such as the assignment of RUNX1 mutations, the rationality of designating AML with mutated TP53 as a unique entity, and the scope of rare genetic fusions, along with the priority of concurrent AML‐defining genetic abnormalities, are still pending questions requiring further research for more elucidated insights.
Expanding the phenotype of UPF3B‐related disorder: Case reports and literature review
Authors: Romano Ferruccio , Haanpää Maria K. , Pomianowski Pawel , Peraino Amanda Rose , Pollard John R. , Di Feo Maria Francesca , Traverso Monica , Severino Mariasavina , Derchi Maria , Henzen Edoardo , Zara Federico , Faravelli Francesca , Capra Valeria , Scala Marcello 
Published: February 2024

AbstractUPF3B encodes the Regulator of nonsense transcripts 3B protein, a core‐member of the nonsense‐mediated mRNA decay pathway, protecting the cells from the potentially deleterious actions of transcripts with premature termination codons. Hemizygous variants in the UPF3B gene cause a spectrum of neuropsychiatric issues including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia/childhood‐onset schizophrenia (COS). The number of patients reported to date is very limited, often lacking an extensive phenotypical and neuroradiological description of this ultra‐rare syndrome. Here we report three subjects harboring UPF3B variants, presenting with variable clinical pictures, including cognitive impairment, central hypotonia, and syndromic features. Patients 1 and 2 harbored novel UPF3B variants—the p.(Lys207*) and p.(Asp429Serfs*27) ones, respectively—while the p.(Arg225Lysfs*229) variant, identified in Patient 3, was already reported in the literature. Novel features in our patients are represented by microcephaly, midface hypoplasia, and brain malformations. Then, we reviewed pertinent literature and compared previously reported subjects to our cases, providing possible insights into genotype–phenotype correlations in this emerging condition. Overall, the detailed phenotypic description of three patients carrying UPF3B variants is useful not only to expand the genotypic and phenotypic spectrum of UPF3B‐related disorders, but also to ameliorate the clinical management of affected individuals.
A longitudinal characterization of the adaptive and behavioral profile in Sotos syndrome
Authors: Siracusano Martina , Dante Caterina , Sarnataro Rachele , Arturi Lucrezia , Riccioni Assia , Carloni Elisa , Cicala Mariagrazia , Gialloreti Leonardo Emberti , Galasso Cinzia , Conteduca Giuseppina , Coviello Domenico , Mazzone Luigi 
Published: February 2024

AbstractDelineation of a developmental and behavioral trajectory is a key‐topic in the context of a genetic syndrome. Short‐ and long‐term implications concerning school outcome, independent living, and working opportunities are strictly linked to the cognitive and behavioral profile of an individual. For the first time, we present a longitudinal characterization of the adaptive and behavioral profile of a pediatric sample of 32 individuals with Sotos Syndrome (SoS) (18 males, 14 females; mean age 9.7 ± 4 years, eight carrying the NSD1 5q35 microdeletion and 24 with an intragenic mutation). We performed two clinical assessments: at baseline (T0) and at distance evaluation (T1) of adaptive and behavioral skills with a mean distance of 1.56 ± 0.95 years among timepoints. Our study reports a stability over the years—meant as lack of statistically significant clinical worsening or improvement—of both adaptive and behavioral skills investigated, regardless the level of Intellectual Quotient and chronological age at baseline. However, participants who did not discontinue intervention among T0 and T1, were characterized by a better clinical profile in terms of adaptive skills and behavioral profile at distance, emphasizing that uninterrupted intervention positively contributes to the developmental trajectory.