bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal for targeted, neo-evolutionary-oriented secondary prevention of early-onset endometriosis and adenomyosis. Part II: medical interventions
Authors: Vercellini Paolo , Bandini Veronica , Viganò Paola , Ambruoso Deborah , Cetera Giulia Emily , Somigliana Edgardo 
Published: November 2023

AbstractAccording to consistent epidemiological data, the slope of the incidence curve of endometriosis rises rapidly and sharply around the age of 25 years. The delay in diagnosis is generally reported to be between 5 and 8 years in adult women, but it appears to be over 10 years in adolescents. If this is true, the actual onset of endometriosis in many young women would be chronologically placed in the early postmenarchal years. Ovulation and menstruation are inflammatory events that, when occurring repeatedly for years, may theoretically favour the early development of endometriosis and adenomyosis. Moreover, repeated acute dysmenorrhoea episodes after menarche may not only be an indicator of ensuing endometriosis or adenomyosis, but may also promote the transition from acute to chronic pelvic pain through central sensitization mechanisms, as well as the onset of chronic overlapping pain conditions. Therefore, secondary prevention aimed at reducing suffering, limiting lesion progression, and preserving future reproductive potential should be focused on the age group that could benefit most from the intervention, i.e. severely symptomatic adolescents. Early-onset endometriosis and adenomyosis should be promptly suspected even when physical and ultrasound findings are negative, and long-term ovulatory suppression may be established until conception seeking. As nowadays this could mean using hormonal therapies for several years, drug safety evaluation is crucial. In adolescents without recognized major contraindications to oestrogens, the use of very low-dose combined oral contraceptives is associated with a marginal increase in the individual absolute risk of thromboembolic events. Oral contraceptives containing oestradiol instead of ethinyl oestradiol may further limit such risk. Oral, subcutaneous, and intramuscular progestogens do not increase the thromboembolic risk, but may interfere with attainment of peak bone mass in young women. Levonorgestrel-releasing intra-uterine devices may be a safe alternative for adolescents, as amenorrhoea is frequently induced without suppression of the ovarian activity. With regard to oncological risk, the net effect of long-term oestrogen–progestogen combinations use is a small reduction in overall cancer risk. Whether surgery should be considered the first-line approach in young women with chronic pelvic pain symptoms seems questionable. Especially when large endometriomas or infiltrating lesions are not detected at pelvic imaging, laparoscopy should be reserved to adolescents who refuse hormonal treatments or in whom first-line medications are not effective, not tolerated, or contraindicated. Diagnostic and therapeutic algorithms, including self-reported outcome measures, for young individuals with a clinical suspicion of early-onset endometriosis or adenomyosis are proposed.
Proposal for targeted, neo-evolutionary-oriented, secondary prevention of early-onset endometriosis and adenomyosis. Part I: pathogenic aspects
Authors: Vercellini Paolo , Bandini Veronica , Viganò Paola , Di Stefano Giorgia , Merli Camilla Erminia Maria , Somigliana Edgardo 
Published: November 2023

Abstract
The potential for repeated ovulation and menstruation is thought to have provided a Darwinian advantage during the Palaeolithic. Reproductive conditions remained relatively stable until the pre-industrial era, characterized by late menarche, very young age at first birth, multiple pregnancies, and prolonged periods of lactational amenorrhoea. For hundreds of thousands of years, menstruators experienced few ovulatory cycles, even though they were genetically adapted to ovulate and menstruate every month. In the post-industrial era, the age at menarche gradually declined, the age at first birth progressively increased, and breastfeeding became optional and often of short duration. This created a mismatch between genetic adaptation and socio-environmental evolution, so that what was initially a probable reproductive advantage subsequently contributed to increased susceptibility to diseases associated with lifetime oestrogen exposure, such as ovarian, endometrial and breast cancer and, hypothetically, also those associated with the number of ovulatory menstruations, such as endometriosis and adenomyosis. The incidence of endometriosis shows a steep and progressive increase around the age of 25 years, but given the consistently reported delay in diagnosis, the actual incidence curve should be shifted to the left, supporting the possibility that the disease has its roots in adolescence. This raises the question of whether, from an evolutionary point of view, anovulation and amenorrhoea should not still be considered the physiological state, especially in the postmenarchal period. However, an increase in the frequency of endometriosis in recent decades has not been demonstrated, although this deserves further epidemiological investigation. In addition, as endometriosis occurs in a minority of individuals exposed to retrograde menstruation, other important pathogenic factors should be scrutinised. Research should be resumed to explore in more detail the transtubal reflux of not only blood, but also endometrial cells, and whether they are systematically present in the peritoneal fluid after menstruation. If repetitive ovulatory menstruation during the early reproductive years is shown to increase the risk of endometriosis and adenomyosis development and progression in susceptible individuals, hormonal interventions could be used as secondary prevention in symptomatic adolescents.
20-Year follow-up and comparison of valved conduits used for right ventricular outflow tract reconstruction: single-centre, propensity score match analysis
Authors: Sabateen Fadi , Soják Vladimír , Nagi Aref Saif , Valentík Pavel , Šagát Michal , Nosál' Matej 
Published: November 2023

Abstract

OBJECTIVES
Surgical repair of complex congenital heart defects with hypoplasia or atresia of the right ventricular outflow tract (RVOT) may require pulmonary valve implantation or replacement during the primary repair or reoperation. The purpose of this study is to evaluate the outcomes of cryopreserved homografts, bovine jugular vein conduits and decellularized Matrix P Plus N conduits in patients undergoing RVOT reconstruction at a single centre.

METHODS
Retrospective, single-centre review of 173 patients with 199 conduits undergoing right ventricle-to-pulmonary artery reconstruction with valved conduit from 2002 to 2022.

RESULTS
A total of 199 conduits were implanted in 173 patients (62.8% male), with a mean age of 8.97 ± 8.5 years. The following 3 types of conduits were used: homografts 129 (64.8%), bovine jugular vein conduits 45 (22.7%) and Matrix P Plus N 25 (12.5%). During the mean follow-up duration of 8.6 ± 5.8 years, there were 20 deaths, 35 conduit reoperations and 44 catheter reinterventions. Overall survival, reoperation-free and catheter reintervention-free survival at 20 years were 83%, 67.8% and 65.6%, respectively. Multivariable Cox analysis identified younger patient age, smaller conduit size, low patient weight and primary diagnosis of common arterial trunk as risk factors for reoperation and catheter reintervention.

CONCLUSIONS
Long-term outcomes of reconstruction of the RVOT using homografts, bovine jugular vein and Matrix P Plus N conduits were acceptable. The reoperation rate for conduit dysfunction did not differ significantly among groups. Over time, the need for conduit replacement was higher in smaller conduits and in patients with common arterial trunk diagnosis.
Equality of the Wobbly and Shaky Loci
Authors: Peón-Nieto Ana 
Published: November 2023

Abstract
Let $X$ be a smooth complex projective curve of genus $g\geq 2$, and let $D\subset X$ be a reduced divisor. We prove that a parabolic vector bundle ${\mathcal{E}}$ on $X$ is (strongly) wobbly, that is, ${\mathcal{E}}$ has a non-zero (strongly) parabolic nilpotent Higgs field, if and only if it is (strongly) shaky, that is, it is in the image of the exceptional divisor of a suitable resolution of the rational map from the (strongly) parabolic Higgs moduli to the vector bundle moduli space, both assumed to be smooth. This solves a conjecture by Donagi–Pantev [ 14] in the parabolic and the vector bundle context. To this end, we prove the stability of strongly very stable parabolic bundles, and criteria for very stability of parabolic bundles.
Validity of 16 AHRQ Patient Safety Indicators to identify in-hospital complications: a medical record review across nine Swiss hospitals
Authors: Havranek Michael M , Rüter Florian , Bilger Selina , Dahlem Yuliya , Oliveira Leonel , Ehbrecht Daniela , Moos Rudolf M , Westerhoff Christian , Beck Thomas , Le Pogam Marie-Annick 
Published: November 2023

Abstract
The validity of the Agency for Healthcare Research and Quality’s Patient Safety Indicators (PSIs) has been established in the USA and Canada. However, these indicators are also used for hospital benchmarking and cross-country comparisons in other nations with different health-care settings and coding systems as well as missing present on admission (POA) flags in the administrative data. This study sought to comprehensively assess and compare the validity of 16 PSIs in Switzerland, where they have not been previously applied. We performed a medical record review using administrative and electronic medical record data from nine Swiss hospitals. Seven independent reviewers evaluated 1245 cases at various hospitals using retrospective data from the years 2014–18. True positives, false positives, positive predictive values (PPVs), and reasons for misclassification were compared across all investigated PSIs, and the documentation quality of the PSIs was examined. PSIs 6 (iatrogenic pneumothorax), 10 (postoperative acute kidney injury), 11 (postoperative respiratory failure), 13 (postoperative sepsis), 14 (wound dehiscence), 17 (birth trauma), and 18 and 19 (obstetric trauma with or without instrument) showed high PPVs (range: 90–99%) and were not strongly influenced by missing POA information. In contrast, PSIs 3 (pressure ulcer), 5 (retained surgical item), 7 (central venous catheter-related bloodstream infection), 8 (fall with hip fracture), and 15 (accidental puncture/laceration) showed low PPVs (range: 18–49%). In the case of PSIs 3, 8, and 12 (perioperative embolism/thrombosis), the low PPVs were largely due to the lack of POA information. Additionally, it was found that the documentation of PSI 3 in discharge letters could be improved. We found large differences in validity across the 16 PSIs in Switzerland. These results can guide policymakers in Switzerland and comparable health-care systems in selecting and prioritizing suitable PSIs for quality initiatives. Furthermore, the national introduction of a POA flag would allow for the inclusion of additional PSIs in quality monitoring.
Top Rated or Best Seller? Cultural Differences in Responses to Attitudinal versus Behavioral Consensus Cues
Authors: Barnes Aaron J , Shavitt Sharon 
Published: November 2023

Abstract
Marketers commonly use consensus cues about others’ behavioral choices (“best seller”) or their attitudes (“top rated”) when labeling products. This article suggests that the effectiveness of these types of cues may differ across cultures in ways that carry implications for marketing practice. Prior research shows that in contexts that give rise to an interdependent cultural self-construal, choices are often responsive to social expectations rather than personal preferences. We propose that, because interdependents expect such behavioral conformity, cues that convey consensus about others’ choices may be less diagnostic and, thus, less persuasive than cues that convey consensus about others’ attitudes. Five studies examining cultural self-construal in multiple ways, along with two cross-national industry datasets, offer evidence consistent with this reasoning, suggesting that, among interdependents, behavioral consensus cues can actually be less effective than attitudinal ones, reducing persuasion and willingness to pay. However, among independents, because attitudes are assumed to influence behavioral choices, whether the consensus cue is attitudinal or behavioral makes little difference.
Role of immune cells in the pathogenesis of myocarditis
Authors: Liu Keyu , Han Bo 
Published: November 2023

Abstract
Myocarditis is an inflammatory heart disease that mostly affects young people. Myocarditis involves a complex immune network; however, its detailed pathogenesis is currently unclear. The diversity and plasticity of immune cells, either in the peripheral blood or in the heart, have been partially revealed in a number of previous studies involving patients and several kinds of animal models with myocarditis. It is the complexity of immune cells, rather than one cell type that is the culprit. Thus, recognizing the individual intricacies within immune cells in the context of myocarditis pathogenesis and finding the key intersection of the immune network may help in the diagnosis and treatment of this condition. With the vast amount of cell data gained on myocarditis and the recent application of single-cell sequencing, we summarize the multiple functions of currently recognized key immune cells in the pathogenesis of myocarditis to provide an immune background for subsequent investigations.
Adoptive cell immunotherapy for breast cancer: harnessing the power of immune cells
Authors: Li Xue , Zhu Yunan , Yi Jinfeng , Deng Yuhan , Lei Bo , Ren He 
Published: November 2023

Abstract
Breast cancer is the most prevalent malignant neoplasm worldwide, necessitating the development of novel therapeutic strategies owing to the limitations posed by conventional treatment modalities. Immunotherapy is an innovative approach that has demonstrated significant efficacy in modulating a patient's innate immune system to combat tumor cells. In the era of precision medicine, adoptive immunotherapy for breast cancer has garnered widespread attention as an emerging treatment strategy, primarily encompassing cellular therapies such as tumor-infiltrating lymphocyte therapy, chimeric antigen receptor T/natural killer/M cell therapy, T cell receptor gene–engineered T cell therapy, lymphokine-activated killer cell therapy, cytokine-induced killer cell therapy, natural killer cell therapy, and γδ T cell therapy, among others. This treatment paradigm is based on the principles of immune memory and antigen specificity, involving the collection, processing, and expansion of the patient's immune cells, followed by their reintroduction into the patient's body to activate the immune system and prevent tumor recurrence and metastasis. Currently, multiple clinical trials are assessing the feasibility, effectiveness, and safety of adoptive immunotherapy in breast cancer. However, this therapeutic approach faces challenges associated with tumor heterogeneity, immune evasion, and treatment safety. This review comprehensively summarizes the latest advancements in adoptive immunotherapy for breast cancer and discusses future research directions and prospects, offering valuable guidance and insights into breast cancer immunotherapy.
Status of and Challenges to the Establishment and Retention of Young, Beginning, and Minority-Owned Logging Businesses in Florida and Georgia
Authors: Ellis Anna M , Conrad Joseph L , Dwivedi Puneet , Green Gary T 
Published: November 2023

Abstract
Most logging businesses in the US South are owned by White males, many of whom are approaching retirement. The purpose of this study was to evaluate the characteristics of logging businesses with a young owner, beginning (new) business owner, and businesses owned by members of a minority group (YBM). In-person interviews were conducted with twelve YBM logging business owners in Florida and Georgia to gather information on business characteristics and perceived barriers to the formation of these businesses. The YBM business owners were more educated, employed more workers, and had similar capital investments relative to other logging business owners. These owners stated that difficulty recruiting quality employees, high startup costs, lack of industry connections, and high insurance premiums were unique obstacles to establishing YBM businesses. Purposeful actions by the forest industry, policymakers, and other stakeholders may encourage the formation and retention of YBM logging businesses.
Study Implications: As the current generation of logging business owners leaves the industry, it is important to develop new businesses. New businesses will likely be owned by young owners, mid-career professionals starting new logging businesses (beginning businesses), and businesses owned by members of a minority group (YBM). Targeted efforts by loggers’ associations, the forest industry, and other stakeholders that provide business management training, develop a skilled workforce of equipment operators and log truck drivers, and promote policies that result in affordable insurance may encourage the establishment and retention of YBM businesses.
Analytical solutions of free vibration for rectangular thin plate and right-angle triangle plate on the Winkler elastic foundation based on the symplectic superposition method
Authors: Jiang Hao-Jie , Chen Tong-Bo , Ren Yu-Xiang , Gao Ning-Hua 
Published: November 2023

Abstract
Based on the symplectic superposition method, the free vibration models of rectangular and right-angle triangle plates on the Winkler elastic foundation are established in the present paper, and the modes and frequencies are studied. In addition, the theoretical calculation model and finite element analysis model of rectangular thin plate and right-angle triangle plate on elastic foundation are established by using Mathematica software and ABAQUS software. It proves that the symplectic superposition method converges very fast and has a good consistency with the finite element simulation results. Analytical results show that foundation stiffness, aspect ratio, and boundary condition have great influences on vibration frequency and mode shape for structures. This paper solved the free vibration problem of rectangular plate and right-angle triangle plate on elastic foundation by using symplectic superposition method. Compared with the inverse or semi-inverse method, this method avoids the process of assuming the form about the solution, hence the result of this method is completely rational.
Peekaboo! The Effect of Different Visible Cash Display and Amount Options During Mail Contact When Recruiting to a Probability-Based Panel
Authors: Bilgen Ipek , Dutwin David , Singh Roopam , Hendarwan Erlina 
Published: November 2023

Abstract
Recent studies consistently showed that making cash visible with a windowed envelope during mail contact increases response rates in surveys. The visible cash aims to pique interest and encourage sampled households to open the envelope. This article extends prior research by examining the effect of additional interventions implemented during mail recruitment to a survey panel on recruitment rates and costs. Specifically, we implemented randomized experiments to examine size (small, large) and location (none, front, back) of the window displaying cash, combined with what part of the cash is shown through the window envelope (numeric amount, face/image), and various prepaid incentive amounts (two $1, one $2, one $5). We used the recruitment effort for NORC’s AmeriSpeak Panel as the data source for this study. The probability-based AmeriSpeak Panel uses an address-based sample and multiple modes of respondent contact, including mail, phone, and in-person outreach during recruitment. Our results were consistent with prior research and showed significant improvement in recruitment rates when cash was displayed through a window during mail contact. We also found that placing the window on the front of the envelope, showing $5 through the envelope compared to $2 and $1, and showing the tender amount compared to the image on the cash through the window were more likely to improve the recruitment rates. Our cost analyses illustrated that the cost difference in printing window versus no window envelope is small. There is no difference in printing cost between front window and back window as they both require custom manufacturing. There is also no cost difference in printing envelopes with small windows versus large windows. Lastly, we found no evidence of mail theft based on our review of the United States Postal Service’s “track and trace” reports, seed mailings sent to staff, and undeliverable mailing rates.
Evaluation of Electron Tomography Capabilities for Shale Imaging
Authors: Frouté Laura , Boigné Emeric , Jolivet Isabelle C , Chaput Eric , Creux Patrice , Ihme Matthias , Kovscek Anthony R 
Published: November 2023

Abstract
Despite the advantageous resolution of electron tomography (ET), reconstruction of three-dimensional (3D) images from multiple two-dimensional (2D) projections presents several challenges, including small signal-to-noise ratios, and a limited projection range. This study evaluates the capabilities of ET for thin sections of shale, a complex nanoporous medium. A numerical phantom with 1.24 nm pixel size is constructed based on the tomographic reconstruction of a Barnett shale. A dataset of 2D projection images is numerically generated from the 3D phantom and studied over a range of conditions. First, common reconstruction techniques are used to reconstruct the shale structure. The reconstruction uncertainty is quantified by comparing overall values of storage and transport metrics, as well as the misclassification of pore voxels compared to the phantom. We then select the most robust reconstruction technique and we vary the acquisition conditions to quantify the effect of artifacts. We find a strong agreement for large pores over the different acquisition workflows, while a wider variability exists for nanometer-scale features. The limited projection range and reconstruction are identified as the main experimental bottlenecks, thereby suggesting that sample thinning, advanced holders, and advanced reconstruction algorithms offer opportunities for improvement.
Infelicitous Conditionals and KK
Authors: Hawthorne John , Isaacs Yoaav 
Published: November 2023

Abstract
Kevin Dorst (2019) uses the ‘manifest unassertability’ of conditionals of the form ‘If I don’t know p, then p’ as a new motivation for the KK thesis. In this paper we show that his argumentation is misguided. Plausible heuristics offer a compelling and nuanced explanation of the relevant infelicity data. Meanwhile, Dorst relies on tools that, quite independently of KK, turn out to be rather poor predictors of the infelicity of indicative conditionals.