bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geopoetics
Authors: Bobbette Adam 
Published: December 2023

AbstractThis article presents an alternative political history of recent planetary thought through an examination of geopoetics rooted in the colonial politics of Indonesia and Cold War geosciences. This history reveals how geopoetics has not been marginal or critical of dominant scientific narratives but has been central to the development of modern theories of the earth. The article traces the roots of that history in colonial Indonesia through debates between geologists, Theosophists, and orientalists, and in colonial endeavors to suppress Javanese Islam through new geological narratives. It considers the work of Johannes Umbgrove, his theory of geopoetry, and its influence on Harry Hess and the theory of plate tectonics. Acknowledging this history shows us just how deeply connected geopoetics is to much longer religious, cosmological, and political conversations about narrating the earth. The article examines how geopoetics has long been preoccupied with understanding the connectivity of nature and catastrophic histories and points to contemporary possibilities for rethinking the relationship between humans, the earth, and cosmos.
Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit
Authors: Glærum Ingvild Lynneberg , Dunville Keagan , Moan Kristian , Krause Maike , Montaldo Nicola Pietro , Kirikae Hinako , Nigro Maximiliano Jose , Sætrom Pål , van Loon Barbara , Quattrocolo Giulia 
Published: December 2023

ABSTRACT
Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. To understand how the persistence of CR cells influences the maturation of hippocampal circuits, we combined a specific transgenic mouse line with viral vector injection to selectively ablate CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. In addition, transcriptomic analysis highlighted significant changes in the expression of synapse-related genes across development. Finally, we were able to identify significant changes in the expression levels of latrophilin 2, a postsynaptic guidance molecule known for its role in the entorhinal-hippocampal connectivity. These findings were supported by changes in the synaptic proteomic content in CA1 stratum lacunosum-moleculare. Our results reveal a crucial role for CR cells in the establishment of the hippocampal network.
CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm
Authors: Le Viet-Hang , Orniacki Clarisse , Murcia-Belmonte Verónica , Denti Laura , Schütz Dagmar , Stumm Ralf , Ruhrberg Christiana , Erskine Lynda 
Published: December 2023

ABSTRACT
Binocular vision requires the segregation of retinal ganglion cell (RGC) axons extending from the retina into the ipsilateral and contralateral optic tracts. RGC axon segregation occurs at the optic chiasm, which forms at the ventral diencephalon midline. Using expression analyses, retinal explants and genetically modified mice, we demonstrate that CXCL12 (SDF1) is required for axon segregation at the optic chiasm. CXCL12 is expressed by the meninges bordering the optic pathway, and CXCR4 by both ipsilaterally and contralaterally projecting RGCs. CXCL12 or ventral diencephalon meninges potently promoted axon outgrowth from both ipsilaterally and contralaterally projecting RGCs. Further, a higher proportion of axons projected ipsilaterally in mice lacking CXCL12 or its receptor CXCR4 compared with wild-type mice as a result of misrouting of presumptive contralaterally specified RGC axons. Although RGCs also expressed the alternative CXCL12 receptor ACKR3, the optic chiasm developed normally in mice lacking ACKR3. Our data support a model whereby meningeal-derived CXCL12 helps drive axon growth from CXCR4-expressing RGCs towards the diencephalon midline, enabling contralateral axon growth. These findings further our understanding of the molecular and cellular mechanisms controlling optic pathway development.
Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state
Authors: Guyer Richard A. , Picard Nicole , Mueller Jessica L. , Ohishi Kensuke , Leavitt Abigail , Murphy Andrew J. , Cornejo Kristine M. , Hotta Ryo , Goldstein Allan M. 
Published: December 2023

ABSTRACT
Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for a significant share of childhood cancer deaths. Prior studies utilizing RNA sequencing of bulk tumor populations showed two predominant cell states characterized by high and low expression of neuronal genes. Although cells respond to treatment by altering their gene expression, it is unclear whether this reflects shifting balances of distinct subpopulations or plasticity of individual cells. Using mouse and human neuroblastoma cell lines lacking MYCN amplification, we show that the antigen CD49b (also known as ITGA2) distinguishes these subpopulations. CD49b expression marked proliferative cells with an immature gene expression program, whereas CD49b-negative cells expressed differentiated neuronal marker genes and were non-cycling. Sorted populations spontaneously switched between CD49b expression states in culture, and CD49b-negative cells could generate rapidly growing, CD49b-positive tumors in mice. Although treatment with the chemotherapy drug doxorubicin selectively killed CD49b-positive cells in culture, the CD49b-positive population recovered when treatment was withdrawn. We profiled histone 3 (H3) lysine 27 acetylation (H3K27ac) to identify enhancers and super enhancers that were specifically active in each population and found that CD49b-negative cells maintained the priming H3 lysine 4 methylation (H3K4me1) mark at elements that were active in cells with high expression of CD49b. Improper maintenance of primed enhancer elements might thus underlie cellular plasticity in neuroblastoma, representing potential therapeutic targets for this lethal tumor.
Heuristic Search for Rank Aggregation with Application to Label Ranking
Authors: Zhou Yangming , Hao Jin-Kao , Li Zhen 
Published: December 2023

Rank aggregation combines the preference rankings of multiple alternatives from different voters into a single consensus ranking, providing a useful model for a variety of practical applications but posing a computationally challenging problem. In this paper, we provide an effective hybrid evolutionary ranking algorithm to solve the rank aggregation problem with both complete and partial rankings. The algorithm features a semantic crossover based on concordant pairs and an enhanced late acceptance local search method reinforced by a relaxed acceptance and replacement strategy and a fast incremental evaluation mechanism. Experiments are conducted to assess the algorithm, indicating a highly competitive performance on both synthetic and real-world benchmark instances compared with state-of-the-art algorithms. To demonstrate its practical usefulness, the algorithm is applied to label ranking, a well-established machine learning task. We additionally analyze several key algorithmic components to gain insight into their operation. History: Accepted by Erwin Pesch, Area Editor for Heuristic Search & Approximation Algorithms. Funding: This work was supported by the National Natural Science Foundation of China [Grant 72371157] and Shanghai Pujiang Programme [Grant 23PJC069]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0019 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0019 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Erratum to “Competitive Two-Agent Scheduling and Its Applications”
Authors: Koulamas Christos , Kyparisis George , Pinedo Michael , Wan Guohua 
Published: December 2023

Erratum to “Competitive Two-Agent Scheduling and Its Applications” The paper “Competitive Two-Agent Scheduling and Its Applications” by Leung, Pinedo, and Wan appeared in Operations Research in 2010. Because competitive agent scheduling has become an active area of research, the paper has garnered its share of citations over the years. This particular direction of scheduling research has become so popular that the book Multiagent Scheduling: Models and Algorithms by Agnetis, Billaut, Gawiejnowicz, Pacciarelli, and Soukhal appeared in 2014. However, one of the results in the Leung et al. paper had a minor error in it. The paper considers a two-agent scheduling problem with a single machine, with each one of the two agents having their own set of jobs. The first agent has as the objective the minimization of the total tardiness of her set of jobs, and the second agent has to ensure that the total completion time of her set of jobs is less than or equal to Q. Leung et al. showed, through a dynamic programming formulation, that this problem can be solved in pseudopolynomial time and determined the time complexity of their algorithm. Their proof contains a minor error. The proper algorithm is still pseudopolynomial but of a slightly higher time complexity.
Lélia Gonzalez: Uma Ponte entre a Descolonização e a Contracolonização da Psicanálise Brasileira
Authors: Jardim Raoni , Souza Herivelto 
Published: December 2023

Trata-se, neste artigo, de explorar o papel da obra de Lélia Gonzalez a partir de um problema que pode ser pensado nos termos de uma encruzilhada epistemológica para a psicanálise: assumir-se em movimento descolonial, descentrado e destituinte com respeito às heranças do contexto colonial dentro do qual ela se constituiu e segue sendo transmitida, e, a partir daí, realizar um outro movimento que passa por elaborar referenciais teóricos próprios, bem como estabelecer modalidades de transmissão coerentes com a realidade histórico-social na qual ela opera. Defendemos que categorias como as de pretuguês, amefricanidade e a reconsideração da função materna a partir da retomada do lugar histórico-cultural da mãe preta são expedientes teóricos com relevância e incidência clínicas que exemplificam como tal encruzilhada epistemológica pode ser vista como um lugar conceitual tanto de impasse quanto de potencialidade criativa contracolonial. Defendemos ainda que tal guinada epistemológica é fundamental para que psicanalistas brasileiros contemporâneos estejam à altura da escuta e do posicionamento em "seu tempo".
Do Narcisismo das Pequenas Diferenças ao Gozo Narcísico
Authors: Fuks Betty , Farias Ana 
Published: December 2023

A proposta desse ensaio é retomar a incursão de Freud, a partir da Primeira Guerra Mundial, na fonte do sofrimento que vem das relações entre os humanos, indicando a novidade que significou o conceito de narcisismo das pequenas diferenças na apreensão dos movimentos coletivos que declaram uma inócua expressão de hostilidade ao outro, ou os que promulgam ações destrutivas e mortíferas contra o outro eleito como seu inimigo absoluto. Com o advento da pulsão de morte, Freud redimensiona o conceito de narcisismo das pequenas diferenças e introduz a ideia de que a satisfação das pulsões que atingem a mais cega fúria de destruição, está conectada a um gozo [Genuβ] narcísico. Esse gozo, na leitura de Lacan, é um mal porque comporta um mal à alteridade. É com esse legado que nos propomos pensar a extensão da psicanálise ao discurso decolonial e outros discursos contra hegemônicos, através do diálogo interdisciplinar, na leitura das linguagens de ódio que enfrentamos em nossa época.
Ensino de Programação para crianças com o uso da ferramenta Scratch
Authors: De Souza Franciely Alves , Junior Ivaldir de Farias 
Published: December 2023

Contexto: Este trabalho relata uma experiência vivenciada em um curso de férias com alunos entre 9 e 12 anos, que durante 1 meses e 1 semana de aula, tiveram a oportunidade de aprender conceitos básicos de programação utilizando a ferramenta Scratch. Metodologia: Nas aulas foram realizadas atividades práticas com o uso dos blocos de programação na ferramenta Scratch, que possibilitaram o embasamento para o desenvolvimento de dois jogos lúdicos, que foram avaliados de forma automática através da ferramenta Dr. Scratch. Resultados esperados: O curso foi concluído com 11 alunos, e entre os resultados destaca-se a evolução do aprendizado no decorrer das atividades realizadas, já que os alunos não possuíam nenhum conhecimento prévio. Além disso, os resultados demonstram o quanto a avaliação automática é eficiente para visualizar a evolução do aprendizado dos alunos, e consequentemente adaptar as aulas para suprir alguma dificuldade que seja percebida a partir dos critérios avaliados. Conclusão: Concluímos que o curso proporcionou um momento de aprendizado diferente, lúdico e dinâmico, onde os alunos tiveram a oportunidade de conhecer novos conceitos e apresentaram resultados significativos ao que foi proposto inicialmente no projeto.
Estratégias para promoção do clima ético positivo sob a perspectiva de enfermeiros hospitalares
Authors: Dalmolin Graziele de Lima , Lanes Taís Carpes , Facin Mariane Buligon , Schutz Thais Costa , Andolhe Rafaela , Ramos Flávia Regina Souza 
Published: December 2023

Objetivo: analisar as estratégias de promoção do clima ético positivo sob a perspectiva de enfermeiros hospitalares. Método: estudo qualitativo e descritivo exploratório, realizado com 182 enfermeiros de um hospital universitário do sul do Brasil. A coleta dos dados ocorreu por meio de um questionário sociodemográfico, laboral e uma pergunta aberta sobre estratégias de promoção do clima ético positivo. A organização dos dados ocorreu no software Atlas TI 8.0, versão 2019, e aplicou-se análise temática dos dados. Recebeu aprovação do Comitê de Ética em Pesquisa da instituição envolvida. Resultados: a macro categoria “Organização do trabalho” elencou itens sobre as relações na equipe, gestão, educação permanente e condições de trabalho. A macro categoria “Dimensão ética do trabalho” se referiu a exigências, valores pessoais e profissionais, expressão e sensibilidade moral. Conclusão: as estratégias de melhores condições de trabalho e organização, bem como o tratamento das questões éticas e relações interpessoais promovem o clima ético positivo.
Phlebosclerosis: An overlooked complication of varicose veins that affects clinical outcome: A case report
Authors: Ren Shi-Yan , Qian Song-Yi , Gao Rong-Ding 
Published: December 2023

BACKGROUND
Phlebosclerosis is a common age-related fibrotic degeneration of the venous wall. It is a disorder rather than a disease, which may cause venous dysfunction and even venous thrombosis. It is rarely reported in patients with varicose veins.
CASE SUMMARY
The present report describes the case of a 70-year-old man with varicose veins, vitiligo, and phlebosclerosis. Venous angiography revealed blood reflux in the superficial and deep veins. The patient underwent surgery to remove the saphenous veins. During the operation, a calcified vein resembling a wooden stick was found, which was surprisingly extracted from the thickened venous wall. A cross-section of this wooden stick-like vein revealed venous fibrosis and calcification, obvious thickening of the venous wall, extensive collagen deposition on the venous wall, hyaline degeneration, and venous sclerosis causing closure of the venous lumen.
CONCLUSION
This is probably the first report of a wooden stick-like structure being found in the venous wall in patients with varicose veins and venous ulcers. Phlebosclerosis can be observed in the late stage of varicose veins complicated by frequent infections and worse clinical outcomes. Therefore, it is important to be aware of this condition and address it rather than overlook it.
„Segðu satt“: Pólitískt traust og væntingar til stjórnmálafólks á Íslandi, 2020-2023
Authors: Valgarðsson Viktor Orri , Sigurgeirsdóttir Sigurbjörg 
Published: December 2023

Pólitískt traust hrundi á Íslandi árið 2008 og náði sér ekki á strik næstu ár þrátt fyrir verulegan efnahagsbata. Árin 2021-2022 virtist traustið hafa náð fyrri hæðum, en óljóst er hvort það var tímabundin aukning vegna heimsfaraldurs eða merki um varanlega þróun. Í þessari rannsókn skoðum við þróun pólitísks trausts á Íslandi undanfarin ár, með áherslu á tvær ólíkar uppsprettur þess: hæfni annars vegar og heilindi hins vegar. Okkar tilgáta er sú að hrunið hafi ekki bara laskað álit íslensks almennings á hæfni stjórnmálafólks, heldur líka á heilindum þeirra. Við prófum tilgátuna óbeint með því að skoða sambandið á milli pólitísks trausts og ólíkra væntinga almennings til stjórnmálafólks, með gögnum úr könnunum tímabilið 2020-2023. Niðurstöðurnar benda til þess að þau sem leggja meiri áherslu á heilindi stjórnmálafólks treysti alþingismönnum minna en þau sem leggja meiri áherslu á hæfni treysti þeim meira, að teknu tilliti til flokksvals og lýðfræðilegra þátta. Sömuleiðis benda niðurstöðurnar til þess að almenningur hafi árin 2020-2022 lagt mesta áherslu á eiginleika sem tengjast hæfni stjórnmálafólks en árið 2023 hafi áherslan færst yfir á heilindi og þá hafi pólitískt traust minnkað aftur á svipað stig og fyrir faraldur.
Þessar niðurstöður benda til þess að þegar íslenskur almenningur leggur áherslu á heilindi í stjórnmálum sé pólitískt traust lágt, en þegar hæfni þykir skipta meira máli sé traustið hærra. Þetta gæti skýrt hvers vegna pólitískt traust virðist enn ekki hafa náð sér eftir fjármálahrunið þrátt fyrir efnahagsbata, ef íslenskt stjórnmálafólk hefur enn ekki endurheimt orðspor sitt fyrir heilindi.
Involving patients and the public In sTatistIcal Analysis pLans (INITIAL): A delphi survey
Authors: Goulão Beatriz , Morris Tim P. , Blazeby Jane , Gamble Carrol , Gillies Katie , Laidlaw Lynn , Ramsay Craig , Soulsby Irene , Stewart Derek , Totton Nikki 
Published: December 2023

Background
Patient and public involvement (PPI) in trials aims to enhance research by improving its relevance and transparency. Planning for statistical analysis begins at the design stage of a trial within the protocol and is refined and detailed in a Statistical Analysis Plan (SAP). While PPI is common in design and protocol development it is less common within SAPs. This study aimed to reach consensus on the most important and relevant statistical analysis items within an SAP to involve patients and the public.

Methods
We developed a UK-based, two-round Delphi survey through an iterative consultation with public partners, statisticians, and trialists. The consultation process started with 55 items from international guidance for statistical analysis plans. We aimed to recruit at least 20 participants per key stakeholder group for inclusion in the final analysis of the Delphi survey. Participants were asked to vote on each item using a Likert scale from 1 to 9, where a rating of 1 to 3 was labelled as having ‘limited importance’; 4 to 6 as ‘important but not critical’ and 7 to 9 as ‘critical’ to involve patients and the public. Results from the second round determined consensus on critical items for PPI.

Results
The consultation exercise led to the inclusion of 15 statistical items in the Delphi survey. We recruited 179 participants, of whom 72% (129: 36 statisticians, 29 patients or public partners, 25 clinical researchers or methodologists, 27 trial managers, and 12 PPI coordinators) completed both rounds. Participants were on average 48 years old, 60% were female, 84% were White, 64% were based in England and 84% had at least five years’ experience in trials. Four items reached consensus regarding critical importance for patient and public involvement: presentation of results to trial participants; summary and presentation of harms; interpretation and presentation of findings in an academic setting; factors impacting how well a treatment works. No consensus was reached for the remaining 11 items. In general, the results were consistent across stakeholder groups.

Discussion
We identified four critical items to involve patients and the public in statistical analysis plans. The remaining 11 items did not reach consensus and need to be considered in a case-by-case basis with most responders considering patient and public involvement important (but not critical). Our research provides a platform to enable focused future efforts to improve patient and public involvement in trials and enhance the relevance of statistical analyses to patients and the public.
Can digital transformation reduce corporate stock price crashes?
Authors: Zhao Xing , Li Xiangqian , Ren Changman 
Published: December 2023

Purpose
The purpose of this paper is to study the impact of enterprises’ digital transformation on the risk of stock price crashes, but also to study the mediating role of enterprises’ financialization and accounting conservatism in the enterprises’ digital transformation on stock price crash risk.

Design/methodology/approach
Based on the data of 2,599 listed companies in China from 2010 to 2019, this paper constructs indicators of enterprise digital transformation through word frequency analysis method, and uses fixed-effects model and mediated-effects model to explore the impact and mechanism of enterprise digital transformation on the stock price crash risk.

Findings
This study shows that firms’ digital transformation reduces the risk of stock price crashes and that financialization of firms and accounting conservatism play a significant mediating effect between enterprises’ digital transformation and the risk of stock price crashes.

Originality/value
This study enriches the study of stock price crash risk by including digital transformation in the field of stock price crash research, and it examines the mediating roles of financialization of enterprises and accounting conservatism, which provides a new explanatory mechanism to the study of the correlation between digital transformation of enterprises and the risk of stock price crash.
Prevalence and correlates of unintentional nonfatal injuries among school-going adolescents in Central America
Authors: Pengpid Supa , Peltzer Karl 
Published: December 2023

Abstract

Objectives
The aim of this study is to report on the frequency of serious physical injuries (SPI) among adolescents in Central America during the previous decade, 2009–2018.

Methods
In total, 15,807 school adolescents (14.4 years mean age; SD=1.4) from six Central American countries participated in cross-sectional Global School-based Student Health Surveys in 2009–2018 (ranging from 1,779 students in Honduras in 2012 to 4,374 students in Guatemala in 2015).

Results
The prevalence of SPI was 33.8 % (22.9 % once, 7.4 % 2 or 3 times and 3.6 % 4 or more times), ranging from 31.8 % in Guatemala to 45.0 % in Belize and 45.6 % in Panama. The most frequent causes of SPI included fall (11.4 %, ranging from 6.9 % in Costa Rica to 15.6 % in Panama), and the type of SPI was fracture/dislocation (5.7 %, ranging from 4.3 % in Costa Rica to 6.7 % in Panama). In adjusted Poisson regression, male sex, food insecurity, a history of alcohol intoxication, soft drink consumption, fast food intake, truancy, multiple sexual partners, psychological distress, physical fight, physically attacked, bullied, and suicide attempt were significantly associated with a higher number of injury event counts.

Conclusions
Overall, about one in three adolescents in Central America had sustained unintentional injuries in the past 12 months and several contributing factors were identified which if addressed could aid injury prevention among adolescents.