bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESARROLLO DE VACUNAS CONTRA EL SARS-COV-2 RELACIONES ENTRE REGULACIÓN SANITARIA Y LA PROPIEDAD INTELECTUAL
Authors: Hernández Qfb. Antonio , Murillo Cisneros Qfb. Ligia Mariana , Parra Cervantes Dra. Patricia , Soto Vázquez Dr. Ramón , Herrera Marquez Dra. Alma X. 
Published: November 2023

Mucho se ha descrito, investigado, discutido sobre el SARS CoV-2 responsable de la enfermedad COVID-19, sin duda las investigaciones realizadas en torno a la naturaleza del virus, las diferentes terapias o bien las diversas formas de prevenir la enfermedad, como resultado de todas las investigaciones existen productos de carácter científico y tecnológico, de los cuales existen fuertes polémicas sobre los elementos de propiedad intelectual involucrados en este proceso. Se sabe que la propiedad intelectual protege los productos de las actividades de investigación y desarrollo en favor de los investigadores, las instituciones o las empresas que invierten recursos económicos importantes a favor de las investigaciones mientras que, desde el enfoque social hay una tendencia a no proteger mediante patente las soluciones médicas, tecnológicas y farmacéuticas para este problema de salud. En este artículo de opinión se revisó la literatura más relevante sobre la enfermedad COVID-19 y a través de la investigación documental de artículos científicos, libros, páginas médicas electrónicas y patentes específicamente lo relacionado con las vacunas contra la COVID-19; se estudió el desarrollo tecnológico de las diversas plataformas de la obtención de vacunas, así como las características Biológicas del virus SARS-CoV-2 y la enfermedad COVID-19. En este tenor se revisó también el aspecto regulatorio a cumplir para la aprobación emergente de la vacuna contra el virus SARS CoV-2 para cada una de las plataformas tecnológicas por parte de la Organización Mundial de la Salud y de la agencia regulatoria de México, la Comisión Federal contra Riesgos Sanitarios cuyas siglas son COFEPRIS, en este rubro de consideraron otras figuras de propiedad industrias como marcas, diseños industriales. Otro aspecto no menos importante en el campo de la Propiedad Intelectual son los derechos de autor los cuales tienen una importancia relevante principalmente por las publicaciones.

En este artículo finalmente se describe la importancia de las vacunas frente al retorno a clases presenciales a la nueva normalidad incluyendo la rama educativa, en particular lo referente a los estudiantes del área de las ciencias químico-biológicas; se consideran los pensamientos que muchos científicos consideran puntos a favor o en contra por el derecho de patentes al desarrollo de las vacunas.
CAPITAL SOCIAL VINCULANTE Y ESTRÉS ACADÉMICO EN ESTUDIANTES UNIVERSITARIOS
Authors: Castro Torres Mario Eduardo , Vargas-Piérola Pablo Marcelo , Pinto Carlos F. , Alvarado Rubén 
Published: November 2023

Aunque el estrés académico (EA) es un problema con alta incidencia en universitarios, hay pocos estudios sobre el tema. Este trabajo busca determinar si existe correlación entre el capital social vinculante (CSV) y sus dimensiones (tamaño de red, confianza, reciprocidad y propiedad de los recursos) con los síntomas psicológicos (SPsi) del EA, determinando su fuerza y significancia. Método: Se evaluó la correlación entre las dimensiones del CSV con los SPsi del EA en una muestra de 150 estudiantes universitarios voluntarios. Se usó el coeficiente de Spearman (rs) para establecer la correlación, la prueba de independencia de Chi-cuadrado de Pearson (X2) para establecer la diferencia entre grupos y el análisis de residuos (Rü) para determinar dirección y significancia. Resultados: Un tercio de los estudiantes presenta alta frecuencia de SPsi mientras que la cuarta parte una regular. El CSV tiene una correlación negativa, débil y significativa con los SPsi (rs(123)= -.18, p= .040), al igual que la confianza (rs(123)= .-19, p= .031). Adicionalmente, se identificó una correlación negativa, significativa y fuerte entre la dimensión confianza del CSV y el SPsi 20 [ansiedad, angustia o desesperación] del EA (X2= 4.83; gl= 1; p= .028; V de Cramer= 0.21). Discusión: El tamaño del efecto de las correlaciones da cuenta de que existen otras variables involucradas en la relación entre capital social y EA, lo que implica mediación. Es necesario mejorar a futuro la explicación de la relación entre CSV y EA incluyendo más variables en un modelo más complejo de análisis.
Palabras clave: capital social, estrés académico, síntomas psicológicos, estudiantes universitarios.
Fahri Trafik Müfettişliği: İdare Hukuku Boyutuyla Kısa Bir Eleştiri
Authors: BOZ Selman Sacit , GEZGİNCİ Yunus Emre 
Published: November 2023

Fahri trafik müfettişliği, sosyal yaşantıda hissettirdiği etki dolayısıyla neredeyse herkes tarafından bilinmektedir. Sürücülerin trafik kurallarına uyup uymadığını denetlemekle sorumlu olan yetkililere yardımcı olmak üzere ihdas edilen fahri trafik müfettişliği, trafik denetimi, trafik suç ve suçlularının azaltılması alanında faaliyet göstermektedir.
Trafik güvenliğini sağlama, trafik kültürüne katkıda bulunma, trafik denetimi yapma şeklinde öngörülen görevler, kamu görevinin ifası anlamındadır. Fahri trafik müfettişi, yürüttüğü trafik denetimi bağlamında ayrıca tutanak düzenleme yetkisine de sahiptir. Fahri trafik müfettişinin statüsü, yürütmüş olduğu görev ve yaptığı işlemlerin hukuki nitelendirmesi herhangi bir mevzuatta yapılmamıştır. Bu nedenle nitelendirmenin teorik olarak, idare hukukuna dair ilkeler ve yargı kararları çerçevesinde yapılması gerekir.
Analisis Pola Distribusi Dan Penetapan Harga Hasil Tangkapan Ikan Di Pangkalan Pendaratan Ikan (PPI) Labuang Maros
Authors: Ramadani Soraya , Ghadi Jasmani , Khatimah Khusnul 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pola distribusi hasil tangkapan ikan pada tiga musim penangkapan di Pangkalan Pendaratan Ikan Labuang, penetapan harga hasil tangkapan ikan di Pangkalan Pendaratan Ikan Labuang, dan faktor apa saja yang mempengaruhi distribusi ikan di Pangkalan Pendaratan Ikan Labuang. Pengambilan sampel penelitian ini adalah nelayan,pedagang pengumpul, pedagang perantara, dan pedagang eceran di pangkalan pendaratan ikan Labuang Kelurahan Pattuadae Kecamatan Turikale Kabupaten Maros. Untuk mengolah data, digunakan analisis deskriptif kualitatif, rumus penetapan harga Margin, dan regresi linear berganda. Hasil penelitian menunjukkan bahwa pola distribusi ada dua saluran yaitu:

Nelayan - Pedagang Pengumpul - Pedagang Perantara - Pedagang Pengecer - Konsumen
2. Nelayan - Pedagang Pengumpul - Pedagang Perantara - Konsumen

Penentuan pengambilan keuntungan ditentukan oleh pedagang dan bersifat tidak menentu. Nilai keuntungan tersebut merupakan nilai maksimal yang ditentukan pedagang. Nilai keuntungan dapat berubah sesuai dengan transaksi pasar yang memungkinkan terjadinya tawar menawar. Faktor distribusi harga jual ikan (X1), jumlah tangkapan (X2), biayal (X3), lembaga pemasaran, permintaan konsumen dan musim berpengaruh nyata terhadap jumlah ikan yang terjual pada α = 0,05 (T-tabel = 1,68).
Un universo de una galaxia, el descubrimiento de las galaxias y el cambio a los enfoques modernos del cosmos
Authors: Smith Robert W. , Polzella Silvia 
Published: November 2023

Los astrónomos de finales del siglo diecinueve y principios del veinte estaban muy poco interesados en el universo en general, en su historia y en lo que había más allá de nuestro sistema galáctico, así como en lo que a veces se denomina cosmos termodinámico. Algunos estaban muy preocupados por la estructura de nuestro propio sistema galáctico, pero los astrónomos no desempeñaban prácticamente ningún papel en los debates de finales del siglo diecinueve sobre la naturaleza más amplia del cosmos. El universo infinito más allá de nuestro sistema estelar era un territorio que los astrónomos profesionales estaban más que contentos de dejar a los matemáticos, físicos, filósofos y algunos divulgadores. En este artículo examinaré estas actitudes y por qué y cómo cambiaron. A continuación, hablaré del descubrimiento de las galaxias, que será el tema central de la última sección del artículo
Publicación original: Smith, R. W. (2015). A One Galaxy Universe, the Discovery of Galaxies and the Shift to Modern Approaches to the Cosmos. En K. Freeman, B. Elmegreen, D. Block, & M. Woolway (Eds.), Lessons from the Local Group (pp. 401-411). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-10614-4_33
De forførte som oprørere
Authors: Tobias-Renstrøm Sebastian 
Published: November 2023

“Nogen burde gøre noget!” Men hvorfor gør ingen egentligt det? En politisk motiveret psykologi bør være i stand til at forklare os, hvordan folk begynder at gøre oprør imod systemer, som de ikke finder tilfredsstillende, men også hvorfor de nogle gange ikke gør dette. I denne artikel vil jeg bruge begrebet om begær som en teoretisk prisme for at søge at forstå dette problem ved at stille spørgsmålet: hvordan får man folk til at ville oprøret? Dette udfoldes med eksemplet om psykologistuderende på Københavns Universitet, hvor jeg selv er uddannet fra, som bruges til at understøtte den teoretiske og begrebsmæssige udvikling.
Artiklen begynder med en indledende syntetisering af en begrebslig struktur, som skal tjene det formål at kunne forklare teoretisk, hvad det vil sige at begære noget, som indebærer et oprør – altså at ville det. Med udgangspunkt i Bernard Stieglers filosofi og Hartmut Rosas sociologi søges herefter at beskrive, hvordan begæret kan knægtes eller på anden måde omdirigeres, hvilket i en teoretisk for- stand kan gøre begæreret om oprøret umuligt. Det vil blive søgt demonstreret, at det er muligt at bekæmpe det system, der knægter begærsstrukturerne, igennem ideologikritikken som interpellation (Nissen, 2012). I artiklen bliver disse teorier videreudviklet ved at inddrage

begrebet om performance (Butler, 1988), som reatikuleres til en forførende praksis (Laplanche, 2011). Opsummerende argumenterer jeg i denne artikel for, at reartikulationen som gensidigt interpellerende praksis af forførelse kan muliggøre begæret af det, der indebærer oprøret, og der argumenteres ydermere for at sådanne et begær er nødvendigt for at et oprør kan finde sted. Der gives et bud på, hvordan sådan en reartikulation kan se ud vedrørende eksemplet med de psykologistuderende. Slut- teligt reflekteres der kort over, hvad der sker “dagen efter oprøret”.
Manipulating network connectance by altering plant attractiveness
Authors: Russo Laura , Stout Jane C. 
Published: November 2023

Background
Mutualistic interactions between plants and their pollinating insects are critical to the maintenance of biodiversity. However, we have yet to demonstrate that we are able to manage the structural properties of these networks for the purposes of pollinator conservation and preserving functional outcomes, such as pollination services. Our objective was to explore the extent of our ability to experimentally increase, decrease, and maintain connectance, a structural attribute that reflects patterns of insect visitation and foraging preferences. Patterns of connectance relate to the stability and function of ecological networks.

Methods
We implemented a 2-year field experiment across eight sites in urban Dublin, Ireland, applying four agrochemical treatments to fixed communities of seven flowering plant species in a randomized block design. We spent ~117 h collecting 1,908 flower-visiting insects of 92 species or morphospecies with standardized sampling methods across the 2 years. We hypothesized that the fertilizer treatment would increase, herbicide decrease, and a combination of both maintain the connectance of the network, relative to a control treatment of just water.

Results
Our results showed that we were able to successfully increase network connectance with a fertilizer treatment, and maintain network connectance with a combination of fertilizer and herbicide. However, we were not successful in decreasing network connectance with the herbicide treatment. The increase in connectance in the fertilized treatment was due to an increased species richness of visiting insects, rather than changes to their abundance. We also demonstrated that this change was due to an increase in the realized proportion of insect visitor species rather than increased visitation by common, generalist species of floral visitors. Overall, this work suggests that connectance is an attribute of network structure that can be manipulated, with implications for management goals or conservation efforts in these mutualistic communities.
In-vitro Pharmacological Investigation of Ludwigia adscendens
Authors: Bhuiyan Md. Anik , Shomudro Hasib Khan , Chowdhury Sadia Afreen 
Published: November 2023

Aims: This research objective was to investigate some in-vitro properties of methanol-extracted plant extracts of Ludwigia adscendens (the water primrose). The primary method of assessment for the methanolic extract of Ludwigia adscendens (MELA) was investigated for phytochemical screening. It was determined to look into the plant's potential for in vitro activities, such as antioxidant, antimicrobial, anti-inflammatory anti-arthritis, cytotoxic, thrombolytic and membrane stabilizing activity due to the pharmaceutical interest in its component parts.
Methodology: Phytochemical screening was performed utilizing a battery of test reagents. Antioxidant, antimicrobial, anti-inflammatory, anti-arthritic, cytotoxic, thrombolytic and membrane stabilizing activities were measured at various doses using the DPPH Free Radical Scavenging Assay, the Disk Diffusion Method, Egg Albumin Protein Denaturation Assay, the Inhibition of Protein Denaturation Assay, the Brine Shrimp Lethality Bioassay, Clot lysis assay and heat induced and hypotonic induced haemolysis method.
Results: The findings of research on MELA's phytochemical screening showed the presence of a wide range of various phytochemical components. The higher antioxidant activity of MELA is shown by its IC50 value of 85.76 µg/mL. Significant antibacterial action was shown by MELA. As compared to the standard ascorbic acid, this extract showed significantly greater anti-arthritic and anti-inflammatory effects. MELA exhibited much higher LC50 value which is 1.147 µg/mL than the typical vincristine-sulphate in a lethality test with brine shrimp. Comparatively speaking, this herb has quite powerful thrombolytic action. Significant membrane stabilizing action has also been shown by MELA.
Conclusion: To wrap it up, it is clear that this plants phytochemical can be used for wide range of drug discovery field due to its potent pharmacological actions.
Residual Effect of Integrated Nutrient Management to Preceding Maize on Yield of Succeeding Groundnut under Maize-groundnut Cropping Sequence
Authors: Makwana N. D.  , Bhanvadia A. S.  
Published: November 2023

A field experiment was conducted at Krishi Vigyan Kendra, Anand Agricultural University, Dahod during the years 2020-21 and 2021-22 to study the effect of integrated nutrient management in maize-groundnut cropping sequence. The residual effect of INM treatment applied to preceding rabi maize crop was beneficial for increasing growth and yield attributing characters of succeeding summer groundnut crop viz., plant height and number of branches per plant, number of pods per plant, pod yield and haulm yield per hectare as influenced by different treatments. The residual effect of combination of organic and inorganic to preceding rabi maize crop, application of 75% RDN through inorganic fertilizer + 25% RDN through vermicompost + Bio NPK consortium (M5) produced significantly higher pod and haulm yields which was at par with 75% RDN through inorganic fertilizer + 25% RDN through FYM + Bio NPK consortium in two years of pooled data. Among the levels of RDF, directly applied to summer groundnut, significantly higher yield attribute, pod and haulm yield was recorded with the application of 100% RDF (G1) which was at par with 75% RDF + Bio NP consortium (G2) in two years of pooled experiment data.
Association between Facial, Occlusal and Cephalometric Characteristics of Individuals in Pre-Orthodontic Treatment Phase: A Retrospective Study
Authors: Otoni Rejane Pereira , Viana Chayenne , Ribeiro Giovanna Vanini de Souza Amorim , Silva Larissa Doalla de Almeida e , Neri Anna Marina Teixeira Rodrigues , Silva Ângelo Fonseca , Santos Carolina Carvalho de Oliveira , Fonseca-Silva Thiago 
Published: November 2023

Introduction: The study of the prevalence of malocclusion is important for the knowledge of the common occlusal and facial characteristics of a given population, enabling the prevention, treatment and planning of cases with orthodontic needs.
Objective: The aim of the present study was to evaluate the association between facial, occlusal, and cephalometric findings of individuals in the pre-orthodontic treatment phase.
Materials and Methods: This retrospective cross-sectional study was conducted from a sample of 122 orthodontic medical records of patients in the initial phase of orthodontic treatment. Data related to clinical examination, facial analysis, model analysis, radiographic examinations and intra and extraoral photographs were analyzed. Data on facial type, smile classification and aesthetic pleasantness of the face and smile were collected from extraoral photographs. The occlusal findings were analyzed from plaster models. The cephalometric analysis was evaluated from lateral cephalogram of the face. The collected data were tabulated using the SPSS 17.0 for Windows software and the Chi-square, Kruskal, Wallis and Mann-Whitney tests were used to compare the data.
Results: The most prevalent Angle malocclusion was Class II division 1. Statistical association was observed between the variable Angle malocclusion and the following characteristics: facial type, posterior crossbite, anterior crossbite, anterior open bite, overjet, and overbite (p≤0.05). The Kruskal Wallis and Mann-Whitney tests showed that Class II malocclusion was associated with higher PgNB, NAP, ANB, 1-NB, IMPA, Line S-Ls and overjet values (p≤0.05).
Conclusion: It can be concluded that the population studied has a high prevalence of Class II division 1 malocclusions and this condition is associated with facial, occlusal, and cephalometric findings.
Implications of High Tumor Burden on Chimeric Antigen Receptor T-Cell Immunotherapy
Authors: Ventin Marco , Cattaneo Giulia , Maggs Luke , Arya Shahrzad , Wang Xinhui , Ferrone Cristina R. 
Published: November 2023

ImportanceChimeric antigen receptor (CAR) T-cell therapy has redefined the therapeutic landscape of several hematologic malignant tumors. Despite its clinical efficacy, many patients with cancer experience nonresponse to CAR T-cell treatment, disease relapse within months, or severe adverse events. Furthermore, CAR T-cell therapy has demonstrated minimal to no clinical efficacy in the treatment of solid tumors in clinical trials.ObservationsA complex interplay between high tumor burden and the systemic and local tumor microenvironment on clinical outcomes of CAR T-cell therapy is emerging from preclinical and clinical data. The hallmarks of advanced cancers—namely, inflammation and immune dysregulation—sustain cancer progression. They negatively affect the production, expansion, antitumor activity, and persistence of CAR T-cell products. Understanding of CAR T-cell therapy, mechanisms underlying its failure, and adverse events under conditions of high tumor burden is critical for realizing the full potential of this novel treatment approach.Conclusions and RelevanceThis review focuses on linking the efficacy and safety of CAR T-cell therapy with tumor burden. Its limitations relative to high tumor burden, systemic inflammation, and immune dysregulation are discussed. Emerging clinical approaches to overcome these obstacles and more effectively incorporate this therapeutic strategy into the treatment paradigm of patients with solid malignant tumors are also described.
Sensing Mucus Physiological Property In Situ by Wireless Millimeter‐Scale Soft Robots
Authors: Xiao Boyang , Xu Yilan , Edwards Steven , Balakumar Lohit , Dong Xiaoguang 
Published: November 2023

AbstractThe physiological property of mucus is an important biomarker for monitoring the human health conditions and helping understand disease development, as mucus property such as viscosity is highly correlated with inflammation and other diseases. However, it remains challenging to sense mucus viscosity using pure medical imaging. Collecting and analyzing mucus sample in vitro using flexible endoscopes and capsule endoscope robots is also challenging due to their difficulty of accessing very confined, tortuous, and small spaces, and the sample may not reflect the real mucus property. Here a novel method is proposed to enable sensing mucus viscosity in situ by wireless miniature sensors actuated by magnetic fields and tracked by medical imaging. These miniature viscosity sensors can be delivered with minimal invasion using a novel sensor delivery mechanism by controlling a magnetically actuated millimeter‐scale soft climbing robot. As the soft robot can access confined and narrow spaces, and reliably deploy the sensor on soft tissue surfaces, multiple sensors can be delivered on soft biological tissues to sense biofluid viscosity spatiotemporally. The proposed minimally invasive robotic delivery and viscosity sensing method thus paves the way toward sensing biofluid properties deep inside the body for future disease monitoring and early diagnosis functions.
Multiresponsive MXene Actuators with Asymmetric Quantum‐Confined Superfluidic Structures
Authors: Ma Jia‐Nan , Ma Bo , Wang Zheng‐Xiao , Song Pu , Han Dong‐Dong , Zhang Yong‐Lai 
Published: November 2023

AbstractMXene, which is known for its high electrical/thermal conductivity, surface hydrophilicity, excellent mechanical flexibility, and chemical stability, is a versatile and smart material for soft actuators. However, most MXene actuators are fabricated by combining MXene with other inert materials to form a bilayer or multilayer structure. Considering the strain mismatch at multimaterial interfaces under frequent deformation, MXene‐based actuators are generally associated with poor stability, which limits their practical applications. Herein, inspired by the natural quantum‐confined superfluidic (QSF) effect, a multiresponsive MXene actuator that can be driven by moisture, light, and electricity by engineering an asymmetric QSF structure on both sides of the MXene film is reported. The actuation mechanism of the MXene film can be attributed to nonuniform water adsorption, transport, and desorption within the asymmetric QSF channels under moisture, photothermal, and electrothermal stimuli. Interestingly, MXene actuators can be flexibly formed into various shapes under moisture‐assisted mechanical compression, which not only enhances their multiresponsive actuation, but also permits a more complex deformation. As proof‐of‐concept demonstrations, various intriguing applications including a dual‐role robot, a smart shielding curtain, and a dragonfly robot, are fabricated, revealing the potential of MXene actuators for soft robotics.