bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation
Authors: Mueller Jessica L , Stavely Rhian , Guyer Richard A , Soos Ádám , Bhave Sukhada , Han Chris , Hotta Ryo , Nagy Nandor , Goldstein Allan M 
Published: February 2024

Abstract
Regenerative cell therapy to replenish the missing neurons and glia in the aganglionic segment of Hirschsprung disease represents a promising treatment option. However, the success of cell therapies for this condition are hindered by poor migration of the transplanted cells. This limitation is in part due to a markedly less permissive extracellular environment in the postnatal gut than that of the embryo. Coordinated interactions between enteric neural crest-derived cells (ENCDCs) and their local environment drive migration along the embryonic gut during development of the enteric nervous system. Modifying transplanted cells, or the postnatal extracellular environment, to better recapitulate embryonic ENCDC migration could be leveraged to improve the engraftment and coverage of stem cell transplants. We compared the transcriptomes of ENCDCs from the embryonic intestine to that of postnatal-derived neurospheres and identified 89 extracellular matrix (ECM)-associated genes that are differentially expressed. Agrin, a heparin sulfate proteoglycan with a known inhibitory effect on ENCDC migration, was highly over-expressed by postnatal-derived neurospheres. Using a function-blocking antibody and a shRNA-expressing lentivirus, we show that inhibiting agrin promotes ENCDC migration in vitro and following cell transplantation ex vivo and in vivo. This enhanced migration is associated with an increased proportion of GFAP + cells, whose migration is especially enhanced.
DRESS syndrome
Authors: Beck James 
Published: February 2024

ABSTRACT
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is rare but carries significant mortality and morbidity, making early identification and definitive management crucial. The diagnosis of DRESS is made clinically and involves consideration of a broad list of differential diagnoses. Given variable clinical presentations among patients with DRESS syndrome, clinicians should look for common findings and other hallmarks of the syndrome while monitoring for known complications. Additionally, clinicians should maintain a high index of suspicion to avoid missing more mild presentations, such as in this case patient with DRESS syndrome minor.
Animal-assisted therapy in pediatric autism spectrum disorder
Authors: Kilmer Michele , Hong Minju , Randolph Danielle , Reichel Allison , Huetter Sarah , Bowden Madelyn , Kilmer Clay 
Published: February 2024

Abstract:
The use of therapy or service dogs to assist children with autism spectrum disorder (ASD) is increasing in clinical settings. Research studies indicate that children with ASD display enhanced prosocial behavior and emotional regulation when canines are included in therapy. Despite increased application of animal-assisted therapy in clinical and inpatient settings, healthcare providers show limited understanding of best practices for its use and require a research-based approach to incorporate animals effectively into therapeutic plans of care for pediatric patients with ASD.
Postpartum Navigation Decreases Severe Maternal Morbidity Most Among Black Women
Authors: Brown Zenobia , Messaoudi Choukri , Silvia Emily , Bleau Hallie , Meskill Ashley , Flynn Anne , Abel-Bey Amparo C. , Ball Trever J. 
Published: February 2024

(Abstracted from Am J Obstet Gynecol 2023;229:160.e1–8)
Rates of maternal morbidity and mortality are the highest in the United States of any developed country; along with this, many racial and ethnic disparities exist in obstetric care. Postpartum interventions are important in reducing disparities and improving outcomes.
Prenatal Intravenous Magnesium at 30–34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring: The MAGENTA Randomized Clinical Trial
Authors: Crowther Caroline A. , Ashwood Pat , Middleton Philippa F. , McPhee Andrew , Tran Thach , Harding Jane E. 
Published: February 2024

(Abstracted from JAMA 2023;330(7):603–614)
Preterm birth is a focus of many studies and interventions but remains the leading cause of global neonatal morbidity and mortality. One particular risk that is elevated in preterm infants is cerebral palsy, which affects movement and/or posture, causing health problems and high health care costs for children and their families.
Risk of Endometrial Cancer in Asymptomatic Postmenopausal Women in Relation to Ultrasonographic Endometrial Thickness: Systematic Review and Diagnostic Test Accuracy Meta-analysis
Authors: Vitale Salvatore Giovanni , Riemma Gaetano , Haimovich Sergio , Carugno Jose , Pacheco Luis Alonso , Perez-Medina Tirso , Parry John Preston , Török Peter , Tesarik Jan , Corte Luigi Della , Cobellis Luigi , Sardo Attilio Di Spiezio , De Franciscis Pasquale 
Published: February 2024

(Abstracted from Am J Obstet Gynecol 2023;228:22–35.e2)
Endometrial carcinoma (EC) can be suspected in cases of postmenopausal bleeding (PMB) with a thickened endometrium on transvaginal ultrasonography (TVS) examination. Typical guidelines recommend further investigation of PMB when the endometrial lining is greater than 4–5 mm, indicating an elevated risk of EC.
Risk for Congenital Anomalies in Children Conceived With Medically Assisted Fertility Treatment
Authors: Venetis Christos , Choi Stephanie K. Y. , Jorm Louisa , Zhang Xian , Ledger William , Lui Kei , Havard Alys , Chapman Michael , Norman Robert J. , Chambers Georgina M. 
Published: February 2024

(Abstracted from Ann Intern Med 2023;176:1308–1320)
In the United States, more than 2% of all infants are conceived by assisted reproductive technology (ART). Children born from ART have been shown to have up to 50% increased risk for congenital anomalies (CAs) compared with naturally conceived children.
The Anterior Modified San Diego Acetabuloplasty Does Not Increase Superior-Anterior Coverage in Patient-Specific 3D-Printed Models
Authors: Tadlock Joshua C. , Rupp Garrett E. , Farnsworth Christine L. , Bomar James D. , Caffrey Jason P. , Upasani Vidyadhar V. 
Published: February 2024

Background:
Patients with developmental dysplasia of the hip may require pelvic osteotomies to improve acetabular coverage. The purpose of this study was to compare the changes in acetabular version, tilt, and regional coverage angles following the San Diego acetabuloplasty (SDA), the modified San Diego acetabuloplasty (mSDA), and the Pemberton acetabuloplasty (PA).

Methods:
Fourteen patients with developmental dysplasia of the hip and computed tomography (CT) imaging were identified. From CT images, 2 identical pelvises were 3-dimensional-printed for each patient. Bone was printed with rigid material, and cartilage with flexible material. For each model pair, the SDA was performed on one and the PA was performed on the other. CT scans were obtained before and after acetabuloplasties. Next, the bone graft in the SDA model was moved anteriorly, representing the mSDA, and the model was rescanned. Acetabular version, tilt, and coverage angles (posterior, superior-posterior, superior, superior-anterior, and anterior) were calculated. Preoperative to postoperative differences were compared (repeated measures analysis of variance or Wilcoxon signed rank test). The significance was set to P<0.05.

Results:
The mean age at CT was 5.8±1.2 years (range: 3.9 to 7.5 y). All 3 procedures (SDA, mSDA, and PA) significantly increased acetabular tilt; P<0.045), with a similar change observed for all 3 (P=0.868). PA was the only procedure to significantly decrease relative acetabular version (6.5±6.5 degrees, preoperative: 12.9±5.3 degrees; P=0.004). Both the SDA and mSDA procedures significantly increased coverage in the superior-posterior octant (SDA: 92.6±9.3 degrees, mSDA: 92.3±9.8 degrees, preoperative: 81.9±9.5 degrees; P<0.02), with a similar percent change among the 2 (P=1.0). All 3 procedures significantly increased superior coverage (P<0.04); the increase was similar among the 3 (P=0.205). The PA was the only procedure to produce a significant increase in coverage in the superior-anterior octant (91.0±16.7 degrees, preoperative: 74.0±12.1 degrees; P=0.005) or the anterior octant (50.7±11.7 degrees, preoperative: 45.8±8.9 degrees; P=0.012).

Conclusions:
The SDA and mSDA procedures produced similar postoperative changes, primarily in the superior and superior-posterior acetabular octants. Placing the graft more anteriorly did not increase anterior coverage in the mSDA, and only the PA increased coverage in the superior and superior-anterior acetabular octants.
Severe Corneal Damage After Minor Eyelid Surgery: A Case Series
Authors: Bonte Anne-Sophie , Ni Dhubhghaill Sorcha , Leysen Inge , Koppen Carina 
Published: February 2024

Objectives:
To present three cases of serious corneal complications after seemingly minor and uncomplicated eyelid surgery.

Methods:
These cases emphasize the real-world risk of corneal damage after oculoplastic surgery.

Results:
The first case is a 46-year-old man referred to our department with a corneal perforation after bilateral blepharoplasty of both upper and lower eyelids. The second case concerns a 51-year-old woman who suffered an accidental coagulation of the cornea during the removal of upper eyelid papillomas, and the third case is a 55-year-old woman who had severe corneal thinning accompanied by visual loss after an upper lid blepharoplasty. All patients were stabilized without the need for corneal transplantation, although there were significant corneal scars and sequelae.

Conclusions:
Although complications after esthetic oculoplastic surgery are rare, the reported cases show that corneal damage can have a major impact on the patient's vision and quality of life. Strategies such as the use of a corneal shield can be used to mitigate these risks, but their use is debated. Nevertheless, diligent postoperative care is paramount. At the first postoperative visit, a basic visual acuity measurement should be performed. In cases where reduced vision is reported, particularly when accompanied by pain, patients should be urgently referred for specialized eye care.
Validated Calculators Predicting Cesarean Delivery After Induction: Accuracy in an External Population
Authors: Shao Shirley J. , Teal E. Nicole , Lewkowitz Adam K. , Gaw Stephanie L. , Sobhani Nasim C. 
Published: February 2024

(Abstracted from Obstet Gynecol 2023;142:99–107)
A variety of pregnancy conditions result in induction of labor; usually this method is used when the risks of continuing pregnancy outweigh the risks of delivery and to alleviate risk of perinatal death or other adverse outcomes. A significant proportion of labor inductions end in cesarean delivery due to a myriad of factors, but predicting these factors or the likelihood of cesarean delivery at the time of induction is difficult.
Elevated Plasma CXCL8 Concentrations in Significant Fibrosis but Not in Subclinical Rejection After Adult Liver Transplantation
Authors: Campos-Murguia Alejandro , Hupa-Breier Katharina Luise , Hartleben Björn , Wedemeyer Heiner , Taubert Richard , Engel Bastian 
Published: February 2024

Background.
The noninvasive detection of subclinical graft injury including subclinical T cell–mediated rejection (subTCMR) is one of the unresolved challenges after liver transplantation. Recently, serum C-X-C motif chemokine ligand 8 (CXCL8) was proposed as a highly accurate marker of subTCMR in pediatric liver transplant recipients. We aimed to evaluate the accuracy of the quantification of this chemokine for predicting subTCMR in adult liver transplant recipients, as well as its capacity to classify patients who could benefit from immunosuppression reduction.

Methods.
Plasma CXCL8 concentrations were measured retrospectively in a prospectively collected cohort of adult liver transplant recipients with well-characterized histologic phenotypes.

Results.
In total, 78 patients were included. Median plasma CXCL8 concentrations did not differ (P = 0.24) between patients without histological evidence of rejection (3.6 [0.4–22.0] pg/mL), subTCMR (11.5 [0.4–41.0] pg/mL), clinical TCMR (9.4 [0.4–40.5] pg/mL), and other etiologies of graft injury (8.7 [0.4–31.2] pg/mL). Likewise, plasma CXCL8 concentrations did not discriminate between patients within and outside histologic criteria for immunosuppression reduction that were proposed by the 2016 Banff Working Group on Liver Allograft Pathology (cutoff: 10.9 pg/mL, sensitivity: 0.48, and specificity: 0.79). Furthermore, weak correlation was found between plasma CXCL8 and alanine aminotransferase and aspartate aminotransferase (Spearman ρ = 0.18 and 0.25). Patients with significant fibrosis (17.8 [0.4–40.5] pg/mL) showed higher plasma CXCL8 concentrations than patients without fibrosis (8.2 [0.4–41.0] pg/mL; P = 0.05).

Conclusions.
Plasma CXCL8 concentrations are not predictive of subclinical graft injury or of histological criteria for the minimization of immunosuppression in adult liver transplant recipients.
The impact of environmental innovation and national culture on ESG practices: a study of Latin American companies
Authors: Souza Paulo Vitor Souza de , Dalcero Kátia , Ferreira Denize Demarche Minatti , Paulo Edilson 
Published: February 2024

PurposeThis paper aims to examine how environmental, social and governance (ESG) practices are influenced by environmental innovations and how cultural dimensions moderate this interaction in Latin American companies.Design/methodology/approachIn this paper 157 companies from 6 Latin American countries were studied between 2010 and 2021, with a total of 1,204 observations. Data were collected from Refinitiv Eikon®, and results were generated using ordinary least squares regression, with country and year as controls.FindingsESG performance is higher in companies that invest in environmental innovation; innovation positively affects individual ESG factors; and masculinity, individualism, indulgence and power distance positively or negatively moderate the relationship between innovation and ESG performance, as well as environmental and social dimensions.Research limitations/implicationsOur findings contribute to the body of knowledge on sustainable practices in different cultures. We draw the attention of standard setters to the impact of innovation and culture on ESG practices in different countries.Practical implicationsBetter understanding of how environmental innovation can mitigate inequality, poverty and environmental issues in Latin America, promoting equitable development and environmental preservation.Social implicationsLatin American countries show significant levels of poverty, social and productive heterogeneity, and deficiencies in sustainable practices. Therefore, providing information on innovation as an incentive for better sustainable policies can promote these practices.Originality/valueOur study fills a gap by examining the specific influence of environmental innovation on ESG performance, particularly through its interactions with cultural dimensions, in a sample of Latin American firms.
A path to success: educational board diversity and its influence on MENA banks’ efficiency and stability
Authors: Issa Ayman , Sahyouni Ahmad , Mateev Miroslav 
Published: February 2024

Purpose
This paper aims to examine how the diversity of educational levels within bank boards influences the efficiency and stability of banks operating in the Middle East and North Africa (MENA) region. Unlike previous studies, this analysis also investigates the role of board gender diversity in moderating the relationship between board educational level diversity and bank efficiency and financial stability in MENA.

Design/methodology/approach
In this study, a sample of 77 banks in the MENA region spanning the years 2011 to 2018 is used. The relationship between the presence of highly educated directors on the board, bank efficiency and stability is assessed using the ordinary least squares method. Additionally, the authors use the Generalized Method of Moments technique to correct endogeneity problem.

Findings
This study establishes a positive association between the presence of directors with advanced educational backgrounds on bank boards and bank efficiency and stability. Furthermore, the inclusion of women on the board strengthens this relationship.

Practical implications
These findings have important implications for policymakers and regulators in the MENA region, suggesting that promoting diversity policies that encourage the participation of highly educated directors on bank boards can contribute to enhanced efficiency and financial stability. Policymakers may also consider implementing quotas or guidelines to improve gender diversity in board appointments, thereby fostering bank performance in the region.

Originality/value
This study stands out for its innovation and distinctiveness, as it delves into the connection between board educational level diversity and bank efficiency in the MENA region. Notably, it surpasses previous research by investigating the moderating role of board gender diversity, thus offering valuable insights into the complex interplay between these two facets of board diversity. This contribution enriches the existing literature by providing novel perspectives on board composition dynamics and its influence on bank efficiency and stability.
Designing for identity: how and when brand visual aesthetics enable consumer diasporic identity
Authors: Buschgens Mark , Figueiredo Bernardo , Blijlevens Janneke 
Published: February 2024

Purpose
This paper aims to investigate how and when visual referents in brand visual aesthetics (i.e. colours, shapes, patterns and materials) serve as design applications that enable consumer diasporic identity.

Design/methodology/approach
This paper uses an innovative methodology that triangulates 58 in-depth interviews with diasporic consumers, 9 interviews with brand managers and designers and a visual analysis of brands (food retailer, spices and nuts, skincare, hair and cosmetics, ice cream and wine) to provide a view of the phenomenon from multiple perspectives.

Findings
This study illustrates how and when particular applications and compositions of product and design referents support diasporic identity for Middle Eastern consumers living outside the Middle East. Specifically, it illustrates how the design applications of harmonising (applying separate ancestral homeland and culture of living product and design referents simultaneously), homaging (departing from the culture of living product and design referents with a subtle tribute to ancestral homeland culture) and heritaging (departing from the ancestral homeland culture product and design referents with slight updates to a culture of living style) can enable diasporic identity in particular social situations.

Research limitations/implications
Although applied to the Middle Eastern diaspora, this research opens up interesting avenues for future research that assesses diasporic consumers’ responses to brands seeking to use visual design to engage with this market. Moreover, future research should explore these design applications in relation to issues of cultural appreciation and appropriation.

Practical implications
The hybrid design compositions identified in this study can provide brand managers with practical tools for navigating the design process when targeting a diasporic segment. The design applications and their consequences are discussed while visually demonstrating how they can be crafted.

Originality/value
While previous research mainly focused on how consumption from the ancestral homeland occurred, to the best of the authors’ knowledge, this study is the first to examine how hybrid design compositions that combine a diaspora’s ancestral homeland culture and their culture of living simultaneously and to varying degrees resonate with diasporic consumers.
Higher education managers’ perception of university reputation components: a model for Middle Eastern countries
Authors: Romiani Yones , Ghoraishi Khorasgani Maryam Sadat , Norollahee Saeid 
Published: February 2024

PurposeNowadays, universities increasingly consider reputation as a key component for improving quality and rankings. A positive reputation opens doors to added value and diverse opportunities. This paper aims to explore Middle Eastern higher education managers' perceptions of university reputation components.Design/methodology/approachGiven the significance of this concept in Middle Eastern universities, a descriptive phenomenological qualitative approach is adopted to identify these key components. The study includes interviews with university managers, and data are collected through semi-structured interviews and analyzed thematically.FindingsThe findings reveal that, from the perspective of higher education managers, university reputation is influenced by four main components: university management and leadership, quality and performance, identity and image and social responsibility. These components are tailored to the context of Middle Eastern countries.Practical implicationsPractical implications are clearly laid out in the form of four key themes for higher education managers in Middle Eastern countries to manage reputation.Originality/valueThe study’s outcomes can be used as a guide for university managers in developing countries to change the situation in their favor and achieve great success in the competitive condition of universities by planning and making policies in this direction. Also, the managers of higher education in the Middle Eastern countries can take advantage of the components of this study to improve the quality and quantity of their universities and take an important step towards increasing the university’s reputation at the international level.
Exploring the mediating role of big data in the relationship between servant leadership and firm performance: insights from private hospitals in India
Authors: Kumar Anup , Chauhan Vinit Singh 
Published: February 2024

PurposeThis study examines the relationship between servant leadership and its dimensions on firm performance, with big data playing the role of a mediator.Design/methodology/approachSurvey responses used for analysis in this study have been taken from business managers associated reputed private sector organizations in India. A conceptual model is proposed grounded to the Conservation of Resource Theory (COR). Structural equation modeling has been used to test the proposed model.FindingsServant leadership significantly relates to firm performance, whereby Big Data is seen to play the role of a mediator. The results also indicate that none of the dimensions of servant leadership independently affect firm performance.Originality/valueThe study adds to extant research by examining the mediating mechanism of Big Data in servant leadership and firm performance. It also suggests that each dimension of servant leadership gets reflected in overall servant leadership. Here it is important to note that Big Data analytics partially mediate the effectiveness of servant leadership.