bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of G3139, a Bcl-2 Antisense Oligonucleotide, in Combination With Dexamethasone and Thalidomide in Relapsed Multiple Myeloma Patients
Authors: Badros Ashraf Z. , Goloubeva Olga , Rapoport Aaron P. , Ratterree Bashi , Gahres Natalie , Meisenberg Barry , Takebe Naoko , Heyman Meyer , Zwiebel James , Streicher Howard , Gocke Christopher D. , Tomic Dragana , Flaws Jodi A. , Zhang Bin , Fenton Robert G. 
Published: May 2005

PurposeBcl-2 regulates the mitochondrial apoptosis pathway that promotes chemotherapy resistance. Bcl-2 antisense oligonucleotide, G3139, targets Bcl-2 mRNA.Patients and MethodsG3139 was administered (3 to 7 mg/kg/d for 7 days) by continuous intravenous infusion. On day 4, patients started thalidomide (100 to 400 mg as tolerated) and dexamethasone (40 mg daily for 4 days) on 21-day cycles for three cycles. Stable and responding patients continued on 35-day cycles for 2 years.ResultsThirty-three patients (median age, 60 years; range, 28 to 76 years) received 220 cycles. Patients received a median of three prior regimens including thalidomide (n = 15) and stem-cell transplantation (n = 31). The regimen was well tolerated; the median number of cycles per patient was eight (range, one to 16+ cycles). Toxicities included reversible increase in creatinine, thrombocytopenia, neutropenia, fatigue, anorexia, constipation, fever, neuropathy, edema, electrolyte disturbances, and hyperglycemia. Fifty-five percent of patients had objective responses, including two complete responses (CRs), four near CRs (positive immunofixation), and 12 partial responses; six patients had minimal responses (MRs). Of patients who received prior thalidomide, seven had objective responses, and three had MRs. The median duration of response was 13 months, and estimated progression-free and overall survival times were 12 and 17.4 months, respectively. Responding patients had significant increase in polyclonal immunoglobulin M (P = .005), indicating innate immune system activation. Western blot analysis of Bcl-2 protein isolated from myeloma cells before and after G3139 demonstrated a decrease of Bcl-2 levels in three of seven patients compared with six of nine patients using reverse transcriptase polymerase chain reaction.ConclusionG3139, dexamethasone, and thalidomide are well tolerated and result in encouraging clinical responses in relapsed multiple myeloma patients.
Social Isolation and Loneliness: Differences between Older Rural and Urban Manitobans
Authors: Havens Betty , Hall Madelyn , Sylvestre Gina , Jivan Tyler 
Published: May 2005

ABSTRACTThe purpose of this paper was to identify predictors of social isolation and loneliness for very old rural and urban adults. With data from the 1996 Aging in Manitoba Study (N= 1,868; age range 72–104), separate multiple regression models were constructed for rural and urban sub-samples, using the life space index (LSI) to measure social isolation as one outcome, and a loneliness index created by the authors from a combination of items to measure loneliness as a second outcome. Different factors were found to predict the outcomes for the two sub-samples. The models with isolation as the outcome produced five predictors for the rural sub-sample and three for the urban sub-sample. Only living alone was the same for both groups. The models with loneliness as the outcome produced five predictors for the rural sub-sample and two for the urban sub-sample, again with only one factor in common – four or more chronic illnesses. We conclude that health and social factors are important predictors of social isolation and loneliness, and sensitivity to these factors may improve the experience of older adults.
European and Canadian Studies of Loneliness among Seniors
Authors: Perlman Daniel 
Published: May 2005

ABSTRACTThis article provides a commentary on a set of five other articles reporting European and Canadian studies of loneliness among seniors. It places those works involving Canadian, Dutch, Finnish, and Welsh samples in the larger context of research on loneliness; offers reflections on the methods and findings reported in the articles; and addresses the question, Is loneliness universal? Points of similarity in the articles are identified and possible ways of reconciling discrepant findings regarding age trends and gender differences are put forward. A discrepancy model of loneliness is used as a key framework for explaining several points, including why objective social isolation and loneliness don't always go together.
Guilhème Pérodeau et Denyse Côté (Eds.). Le virage ambulatoire : Défis et enjeux. Sainte-Foy, QC: Presses de l'Université du Québec. 2002.
Authors: Vézina Aline 
Published: May 2005

ABSTRACTThis book is comprised of three sections: the problems and consequences of the push for more de-institutionalized health care, the issues that crop up in this context, and the perceptions of the caregiver. At the core of this text are the two groups of women who are most present in this new context: the informal caregivers or family helpers and the nurses. Three conclusions become evident. Firstly, the push for home care has many negative consequences, especially for women. Secondly, although the help of a family member makes possible the dispensation of care at home, something wished for by most patients, it also entails an increase in, and professionalization of, the tasks for the caregiving family member. Finally, using the home as the place of care also has the consequence of increasing the tasks of nursing personnel, to the point where there is a perception that the quality of care has decreased.
Distinguishing the geographic levels and social dimensions of U.S. metropolitan segregation, 1960–2000
Authors: Fischer Claude S. , Stockmayer Gretchen , Stiles Jon , Hout Michael 
Published: May 2005

Abstract
In this article, we assess trends in residential segregation in the United States from 1960 to 2000 along several dimensions of race and ethnicity, class, and life cycle and present a method for attributing segregation to nested geographic levels. We measured segregation for metropolitan America using the Theil index, which is additively decomposed into contributions of regional, metropolitan, center city–suburban, place, and tract segregation. This procedure distinguishes whether groups live apart because members cluster in different neighborhoods, communities, metropolitan areas, or regions. Substantively, we found that the segregation of blacks decreased considerably after 1960 largely because neighborhoods became more integrated, but the foreign born became more segregated largely because they concentrated in particular metropolitan areas. Class segregation increased between 1970 and 1990 mainly because the affluent increasingly clustered in specific metropolitan areas and in specific municipalities within metropolitan areas. The unmarried increasingly congregated in center cities. The main purpose of this article is to describe and illustrate this multilevel approach to studying segregation.
Poverty and macroeconomic performance across space, race, and family structure
Authors: Gundersen Craig , Ziliak James P. 
Published: May 2005

AbstractWe examined the effects of macroeconomic performance and social policy on the extent and depth of poverty in America using state-level panel data from the 1981–2000 waves of the Current Population Survey. We found that a strong macroeconomy at both the state and national levels reduced both the number of families who were living in poverty and the severity of poverty. The magnitude and source of these antipoverty effects, however, were not uniform across family structures and racial groups or necessarily over time. While gains in the eradication of poverty, in general, were tempered by rising wage inequality, simulations indicated that female-headed families and families that were headed by black persons experienced substantial reductions in poverty in the 1990s largely because of the growth in median wages. An auxiliary time-series analysis suggests that the expansions in the federal Earned Income Tax Credit of the 1990s accounted for upward of 50% of the reduction in after-tax income deprivation.
Self-care: Why do parents leave their children unsupervised?
Authors: Casper Lynne M. , Smith Kristin E. 
Published: May 2005

AbstractWe used a preferences-and-constraints model to develop four hypotheses to explain why parents may choose self-care (an unsupervised arrangement) as the primary child care arrangement for their children over supervised alternatives and tested them in a multivariate framework using 1995 data from the Survey of Income and Program Participation. We found that the choice of self-care over supervised care alternatives is linked to the availability of parents’ time to care for children, the child’s level of responsibility and maturity, and the neighborhood context. However, we found no evidence that parents’ ability to pay for child care is related to the choice of self-care. The results also suggest that parents use different decision-making processes, depending on their children’s ages.
Decomposition of differences in health expectancy by cause
Authors: Nusselder Wilma J. , Looman Caspar W. N. 
Published: May 2005

Abstract
Health expectancy is a widely used measure for monitoring trends in the health of a population and assessing differences in health among population groups. However, no decomposition method is available to examine the contribution made by causes of death and disability to differences in health expectancy among population groups or periods. We present a method for decomposing differences in health expectancy, based on the Sullivan method. This method is an extension of the decomposition method for life expectancy developed by Arriaga. We illustrate the method and its added value by decomposing male-female differences in health expectancy for the Netherlands.
Orphans in Africa: parental death, poverty, and school enrollment
Authors: Case Anne , Paxson Christina , Ableidinger Joseph 
Published: May 2005

Abstract
We examine the impact of orphanhood on children’s school enrollment in 10 sub-Saharan African countries. Although poorer children in Africa are less likely to attend school, the lower enrollment of orphans is not accounted for solely by their poverty. We find that orphans are less likely to be enrolled than are nonorphans with whom they live. Consistent with Hamilton’s rule, the theory that the closeness of biological ties governs altruistic behavior, outcomes for orphans depend on the relatedness of orphans to their household heads. The lower enrollment of orphans is largely explained by the greater tendency of orphans to live with distant relatives or unrelated caregivers.
Pervasive Muslim-Hindu fertility differences in India
Authors: Dharmalingam A. , Morgan S. Philip 
Published: May 2005

Abstract
Using the 1993 Indian Family and Health Survey, we examined Muslim-Hindu differences in (1) the parity-specific intent to have another child and (2) given a stated intent for no more children, reports of the current use of contraceptives. We found that Muslims are much more likely than Hindus to intend to have additional children and, among those who do not want more children, Muslims are much less likely than Hindus to use contraceptives. These findings are robust to model specification and pervasive across the states of India. This national study provides the context within which local studies should be enmeshed and begs for general (as opposed to place-specific) explanations for these pervasive differences.
Paradox lost: Explaining the hispanic adult mortality advantage
Authors: Palloni Alberto , Arias Elizabeth 
Published: May 2005

Abstract
We tested three competing hypotheses regarding the adult “Hispanic mortality paradox”: data artifact, migration, and cultural or social buffering effects. On the basis of a series of parametric hazard models estimated on nine years of mortality follow-up data, our results suggest that the “Hispanic” mortality advantage is a feature found only among foreign-born Mexicans and foreign born Hispanics other than Cubans or Puerto Ricans. Our analysis suggests that the foreign-born Mexican advantage can be attributed to return migration, or the “salmon-bias” effect. However, we were unable to account for the mortality advantage observed among other foreign-born Hispanics.
Trends in socioeconomic inequalities in mortality in developing countries: The case of child Survival in São Paulo, Brazil*
Authors: Sastry Narayan 
Published: May 2005

Abstract
I examined trends in socioeconomic inequalities in under-five mortality for the state of São Paulo, Brazil, over a 21-year period from 1970 to 1991, during which much of the mortality transition unfolded. During this time, there was a decline in inequality in under-five mortality by household wealth but a substantial increase by mother’s education. Improvements in infrastructure and economic development were associated with lower levels of socioeconomic inequality in under-five mortality. Mother’s education emerged as the key factor underlying socioeconomic inequalities in under-five mortality even as levels of education for women increased and inequality in schooling fell.
The increasing racial disparity in infant mortality: Respiratory distress syndrome and other causes
Authors: Frisbie W. Parker , Song Seung-eun , Powers Daniel A. , Street Julie A. 
Published: May 2005

Abstract
Although substantial declines in infant mortality rates have occurred across racial/ethnic groups, there has been a marked increase in relative black-white disparity in the risk of infant death over the past two decades. The objective of our analysis was to gain insight into the reasons for this growing inequality on the basis of data from linked cohort files for 1989–1990 and 1995–1998. We found a nationwide reversal from a survival advantage to a survival disadvantage for blacks with respect to respiratory distress syndrome over this period. The results are consistent with the view that the potential for a widening of the relative racial gap in infant mortality is high when innovations in health care occur in a continuing context of social inequality. As expected, the results for other causes of infant mortality, although similar, are less striking. Models of absolute change demonstrate that among low-weight births, absolute declines in mortality were greater for white infants than for black infants.
Family structure, intergenerational mobility, and the reproduction of poverty: Evidence for increasing polarization?
Authors: Musick Kelly , Mare Robert D. 
Published: May 2005

AbstractA substantial body of research has demonstrated links between poverty and family structure from one generation to the next, but has left open key questions about the implications of these associations for aggregate-level change. To what extent does intergenerational inheritance affect trends in poverty and single parenthood over time and, in particular, trends in the relative economic positions of single-parent and two-parent families? This article examines how patterns of intergenerational inheritance play out in the population over the long run, using data from the National Longitudinal Surveys and a model of population renewal that takes into account intergenerational mobility and differential fertility across groups that are defined by poverty status and family structure. Our results suggest that current rates of intergenerational inheritance have little effect on population change over time. They account for only a small share of the recent historical change in poverty and family structure and play no role in exacerbating existing economic disparities by family structure.
A decomposition of trends in poverty among children of immigrants
Authors: Van Hook Jennifer , Brown Susan L. , Kwenda Maxwell Ndigume 
Published: May 2005

AbstractPoverty levels among all children in the United States have tended to fluctuate in the past 30 years. However, among the children of immigrants, child poverty increased steadily and rapidly from about 12% in 1970 to 33% in the late 1990s before declining to about 21% in 2000. Using 1970, 1980, 1990, and 2000 Public Use Microdata Samples data, we identified key factors that underlie the fluctuations in immigrant child poverty from 1969 to 1999 and the divergence from children of natives. We found that roughly half the absolute increase in immigrant child poverty can be linked to changing conditions in the U.S. economy that make it more difficult to lift a family out of poverty than 30 years ago. These changes occurred disproportionately among children of parents with lower levels of education, employment, and U.S. experience but not among racial/ethnic minorities. Poverty risks among various racial and ethnic groups converged over time. The relative increase in poverty for immigrant versus native children owes largely to the divergence between immigrant and native families in racial/ethnic composition, parental education, and employment.
Educational selectivity in U.S. Immigration: How do immigrants compare to those left behind?
Authors: Feliciano Cynthia 
Published: May 2005

AbstractCurrent immigration research has revealed little about how immigrants compare to those who do not migrate. Although most scholars agree that migrants are not random samples of their home countries’ populations, the direction and degree of educational selectivity is not fully understood. This study of 32 U.S. immigrant groups found that although nearly all immigrants are more educated than those who remain in their home countries, immigrants vary substantially in their degree of selectivity, depending upon the origin country and the timing of migration. Uncovering patterns of immigrant selectivity reveals the fallacy in attributing immigrants’ characteristics to national groups as a whole and may help explain socioeconomic differences among immigrant groups in the United States.
Remarks on the analysis of causal relationships in population research
Authors: Moffitt Robert 
Published: May 2005

Abstract
The problem of determining cause and effect is one of the oldest in the social sciences, where laboratory experimentation is generally not possible. This article provides a perspective on the analysis of causal relationships in population research that draws upon recent discussions of this issue in the field of economics. Within economics, thinking about causal estimation has shifted dramatically in the past decade toward a more pessimistic reading of what is possible and a retreat in the ambitiousness of claims of causal determination. In this article, the framework that underlies this conclusion is presented, the central identification problem is discussed in detail, and examples from the field of population research are given. Some of the more important aspects of this framework are related to the problem of the variability of causal effects for different individuals; the relationships among structural forms, reduced forms, and knowledge of mechanisms; the problem of internal versus external validity and the related issue of extrapolation; and the importance of theory and outside evidence.
The importance of education-occupation matching in migration decisions
Authors: Quinn Michael A. , Rubb Stephen 
Published: May 2005

Abstract
In this article, we present and test a model that incorporates education-occupation matching into the migration decision. The literature on education-occupation matching shows that earnings are affected by how individuals’ education matches that required by their occupation. Accordingly, individuals with more schooling than required by their occupation have an additional incentive to migrate: the increase in earnings that occurs with a more beneficial education-occupation match. Using data from Mexico, we found statistical support for the importance of education-occupation matching in migration decisions. Education-occupation matching provides a plausible explanation for the mixed findings in the literature on the relationship between educational attainment and migration.
Differences in disability among older women and men in Egypt and Tunisia
Authors: Yount Kathryn M. , Agree Emily M. 
Published: May 2005

AbstractResearch on child survival and health has indicated disparities between boys and girls in selected Middle Eastern countries. Health disparities in later life are understudied in this region. In this article, we examine differences between women and men in later-life activity limitation in Egypt and Tunisia. Difficulty executing physical tasks is more common for women than for men in both study sites, although differences are smaller after adjustment for underlying illness. Differences in the difficulty of executing physical tasks also are sensitive to environmental controls in variable ways across the study sites. The findings caution against the sole use of reported disability in comparative studies of gender and aging.
Cloth and Silver: Pawning and Material Life in Mexico City at the Turn of the Nineteenth Century
Authors: Francois Marie 
Published: May 2005

For most residents of Mexico City at the turn of the nineteenth century, daily life was cash poor. Homemakers with servants or without, merchants and artisans, carpenters and domestic servants all turned to pawnshops to finance routine household, business and recreational needs, some on a daily basis. At the end of the colonial period and in the first decades of independent republican rule, residents from the lower and intermediate ranks of the city commonly raised cash by securing loans with possessions as collateral, leaving clothing, tools, and jewels temporarily with pawnbrokers. Based on more than 8,000 transactions culled from pawnshop records from the 1780s to the 1820s, this article argues that pawning material goods served to alleviate economic and other pressures at the household level.It was mostly women managing households who provided for dependents and/or maintained class and ethnic identities through creative financing strategies that depended on regular use of petty credit mechanisms. Archival documents and literary sources suggest that there were fundamental continuities in this material history of Mexico City from the last decades of the colonial period well into the decades after Independence, which was achieved in 1821. Material goods continued to serve as collateral for small loans throughout the nineteenth century. Pawning was a regular strategy used by many urban residents to negotiate the colonial and post-colonial political economy as well as cultural hierarchies. Petty credit secured by women helped individuals and families steady their precarious foothold on the social ladder of hierarchy. While pawning could allow some to maintain their status or even ascend the ladder, for most people collateral credit cushioned (or simply prolonged) the slip down.