bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and acceptability of integrating an early childhood development intervention into the health-facility setting in Siaya County: findings of a qualitative study
Authors: Onyango Silas , Kitsao-Wekulo Patricia , Okelo Kenneth , Nampijja Margaret , Oyugi Beatrice , Obongo Christopher , Omedo Dickens , Sen Debjeet , Kimani-Murage Elizabeth 
Published: November 2023

Abstract
Background
This paper explores the perceptions and experiences of stakeholders to understand the feasibility and acceptability of integrating early childhood development (ECD) intervention into the health system.
Method
Data were derived from an endline qualitative survey, which was part of a larger ECD study conducted in Siaya County, Kenya. Purposive sampling was used to select participants for the qualitative interviews. We conducted KIIs, focus group discussions (FGDs), and in-depth interviews (IDIs). Analyses were organized according to the preselected thematic areas.
Result
Political goodwill, proper coordination and support, and good linkages between the community and the health facility facilitated the implementation despite the challenges of a shortage of personnel and staff transfers. Integration of ECD intervention into the health system seems feasible in terms of its performance, service provision, information provided, and efficiency. In addition, stakeholders willingly supported the implementation of the intervention at different levels and capacities, which led to perceived acceptability. Furthermore, there was general satisfaction with the implementation due to perceived benefits that could potentially improve children’s developmental outcomes.
Conclusion
This study demonstrates the feasibility of integrating ECD interventions into the health system. Future interventions integrating ECD messages into nutrition and health programs can leverage key drivers identified through this study for smooth and effective integration.
Optimization of nitrogen management reduce nitrogen stress and enhance productivity of super- seeder sown wheat under rice residue incorporation
Authors: L Peace Raising , Singh Virendra Pratap , Chandra Subhash , Shukla Anil , Pareek Navneet , Zhiipao R Rustum , Re Kadapa Sreenivas , Duo Hriipulou , Dorjee Lham , Karthik Rayapati , Singh VK , L Peace Raising 
Published: November 2023

Abstract
The in-situ management of rice straw incorporation is now an essential practice in the rice-wheat cropping system with the growing adoption of super-seeder among farmers. This machinery has made it easier to incorporate rice residues into the soil, crushing and spreading straw evenly for cleaner cultivation. However, the effect of nutrient immobilization due to incorporation of massive organic residues at the initial stage of the decomposition is a major constraint for enhancing yield and productivity. This study investigates the effect of bio-decomposer, nitrogen (N) level, and N scheduling on N immobilization status, dry matter, N accumulation, remobilization, productivity and soil quality variables in super-seeder sown wheat for two consecutive years (2020-21 and 2021-22). The experiment was laid in split-split-plot design without (B0) and with (B1) application of bio-decomposer in main plot and two nitrogen levels 150 (N1) and 180 (N2) kg ha-1 in sub-plot; and three N splits (%) viz., 50: 25:25 (S1), 40: 30: 30 (S2), and 30 :35:35 (S3) in sub-sub-plot and replicated thrice. N concentration and uptake at pre- and post-anthesis were recorded significantly higher with N2 and S1 compared to N1 and S2 and S3 in both years. Post-anthesis N accumulation (post-NA) and N remobilization (NR) with N2 was significantly higher to the tune of 22% and 17% than N1. Dry matter accumulation (DMA) at anthesis and harvest with N2 was significantly higher by 5.7%, while with S1 there is an improvement of 6.2% over S3. The grain yield with N2 and S1 significantly improved by 8.3% and 10.9% (two years mean) compared to N1 and S3, respectively. Soil urease activity (UA) was significantly enhanced with the application of microbial formulation (bio-decomposer), N2, and S1 in comparison to B0, N1 and S3 at 30 and 60 DAS (days after sowing). Besides, use of bio-decomposer also improved soil microbial biomass carbon (SMBC). Hence, the present study revealed that the application of higher N level coupled with higher proportion of basal N resulted in overcoming N stress and could be propounded for sustainable production and higher productivity. The result presented here assumes great significance in proper utilization and conservation of rice residue under rice-wheat cropping system.
Declining household greenhouse gas footprints in Germany: Decomposing the contributions of working time, consumption, mobility, energy efficiency and decarbonization between 2000 - 2019
Authors: Wiedenhofer Dominik , Plank Barbara , Antal Miklós 
Published: November 2023

Abstract
Understanding the drivers of household greenhouse gas (GHG) footprints is crucial for designing measures accelerating emission reductions. Well-documented drivers are demand, energy efficiency and decarbonization of energy supply, while mobility and esp. working time have received less attention.
Herein, the drivers of German household energy and GHG emissions footprints from 2000–2019 are decomposed using extended Kaya Decompositions. Footprints are declining at -1%/year, due to improving energy efficiency and decarbonization overcompensating the growth of per-capita and per-hour incomes. Private mobility footprints decline by -1.4%/year, driven up by growing distances, car-dominated modal splits and growing air travel, compensated by improving energy efficiency and decarbonization, slightly decreasing numbers of trips and stable expenditure on mobility. Aggregate working time is growing, which drives up footprints, while increasing part-time employment resultin small reductions of average per-capita working time.
Part-time work is one form of working time reduction for which assumptions of the Kaya Decomposition are fairly realistic. However macro-economic feedbacks and potentially negative social side-effects of part-time work need to be addressed to design equitable policy measures. Remaining research issues are the roles of work-related trips and mobility on company expenses, delivery services and transport of goods, and targeted analyses for socio-economic groups.
Comprehending and Domesticating of Wild Growing Turkey Tail Mushroom (Trametes versicolor) from Ethiopia on augmented agro-industrial byproducts
Authors: Desisa Buzayehu , Muleta Diriba , Jida Mulisa , Dejene Tatek , Goshu Abayneh , Negi Tadesse , Martin Pablo 
Published: November 2023

Abstract

Despite being one of the most studied white-rot fungi, nothing has been done to discover and domesticate Ethiopia's high-yielding wild Trametes versicolor. Thus, this study was initiated to evaluate the growth performance of T. versicolor on growth media. Accordingly, ten substrates (S1–S10) were formulated by a combination of agroindustrial by-products that mainly constituted sugarcane wastes and animal manures. The effect of substrates on yields, biological efficiencies, and nutritional compositions was examined. The mushroom developed a white, cottony mass on the growth media. T. versicolor cultivated on the S5 combination of 80% sugarcane bagasse, 12% horse manure, and 8% poultry manure had the highest yield (158.33 g/500 g bag) and biological efficiency (31.5%), which had an optimum 31:1 C:N. It has shown good mycelial growth, short colonization, and short pinhead formation time compared to other substrates. Low biological efficiency and yields of 11.50% and 57.67% were obtained from S7, which was not supplemented with nitrogen sources. The content of crude protein, fiber, low fat, and carbohydrates were in the range of 7.46–14.65%, 12.89–18.38%, 0.42–0.53%, and 48.75–66.75%, respectively. The highest nutritional values were obtained from S5, except for carbohydrates from sugarcane bagasse mixed with cotton seed hull (S8). Thus, S5 was found to be a suitable growth medium for domesticating wild T. versicolor mushrooms, particularly in regions where poultry, horse manures, and sugarcane bagasse are abundantly available. Hence, S5 is an optimum substrate for T. versicolor cultivation to improve productivity and nutritional quality at lower costs.
Re-thinking Indoor Humidity Control Strategies: The potential of additive manufacturing with low-carbon, super hygroscopic materials.
Authors: Posani Magda , Voney Vera , Odaglia Pietro , Brumaud Coralie , Dillenburger Benjamin , Habert Guillaume 
Published: November 2023

Abstract

Indoor humidity plays a major role in our comfort and well-being. For this reason, mechanical systems are often used to regulate indoor humidity levels, a choice that can entail relevant embodied and operational carbon emissions. This study offers an alternative solution: using materials that naturally buffer moisture to passively regulate indoor humidity levels.
In this work, a geopolymer composite incorporating industrial waste is implemented via a binder jet 3D-printing technology. The combination of the super hygroscopic nature of the material and optimal geometry allows for an effective reduction of embodied emissions and unlocks an unprecedented potential for passive regulation of indoor humidity. Results show that the adoption of 3D-printed geopolymer-based tiles can improve the annual indoor hygrometric conditions by up to 90% in a library hosting 15 people: a passive performance that is inconceivable to obtain with conventional building materials and manufacturing methods. The 3D-printing technology allows for optimal usage of material and consequent lower embodied emissions. In the case study considered, the environmental impact of using 3D-printed tiles emerges to be lower than adopting a conventional dehumidification system to actively achieve equivalent indoor hygrometric comfort levels over a 15-year time span.
The outcomes of this study pave the way towards merging super hygroscopic low carbon materials with the advanced manufacturing technique of binder jetting in order to regulate indoor humidity levels and reduce indoor environments' dependency on mechanical systems.
Epigenetic Regulation of Host Membrane Protein-encoding Genes Facilitates African Swine Fever Virus Infection
Authors: Zhao Shuhong , Qi Xiaolong , Xiang Yue , Sun Limeng , Xing Lingyu , Zhang Jinfu , Zhang SaiXian , Zhao Qiulin , Guo Yilin , Zhang Lu Zhang Lu , Li Jingjin , Zhou Peng , Zheng Zhuqing , Dai Xueting , Jin Zhe , Jian Yaobang , Li Guosheng , Fu Yanan , Tan Yubei , Zhao Changzhi , Xie Shengsong , Cao Gang , Li Xinyun , Fang Lingzhao , Fu Liangliang , Peng Guiqing 
Published: November 2023

Abstract
African swine fever virus (ASFV) is a highly contagious pathogen specifically infecting porcine alveolar macrophages (PAMs), causing substantial economic losses in pig industry worldwide. However, host receptors and molecular mechanisms underlying the ASFV infection remain unknown, which hinders the relevant vaccine development and precision breeding. Here, we conducted a comprehensive epigenetic profiling of ASFV-exposed PAMs based on the generated 42 functional datasets at both bulk and single-cell resolution. The results showed that transcriptional activity of ARL4C in ASFV-exposed cells was downregulated, thus resulting in intracellular cholesterol accumulation to enhance viral defense. In contrast, ASFV infection induced enhancer-promoter interactions in the host genome to boost transcriptional activity of membrane protein-encoding genes, thereby promoting macrophage activation. Moreover, transcriptional activity of these genes was induced in actively infected macrophages (carrying viral DNA). The gene knockout experiment and the virion attachment assay identified CD244 as a potential host receptor of ASFV, which was associated with host susceptibility. Our findings provide novel insights into the molecular regulation of PAMs during ASFV infection and lay a foundation for vaccine development and precision breeding against ASFV infection.
Neuromodulatory effects of caffeine, vanillin and their combination via the assessment of hippocampal purinergic enzymes and expressions of cholinergic, eNOS, GABA receptor, amyloid protein and histomorphological status of AlCl3-induced Alzheimer’s disease in adult male Wistar rats
Authors: Afolabi Olakunle , Jaiyesimi Kikelomo Folake , Olasehinde Oluwaseun Ruth , Olaoye Oyindamola Adeniyi , Ekakitie Lisa Ilobekemen , Fafure Adedamola Adediran , Adetunji Adedeji Enitan , Oluwafemi Emmanuel Babatunde , Oloyede Omo Ibidun 
Published: November 2023

Abstract
The neurotoxic properties of aluminum (Al) have been associated with Alzheimer's disease (AD) development. Consequently, there has been an increasing interest in exploring how bioactive compounds from functional foods can mitigate the detrimental impact of this redox metal in AD. Hence, this study evaluated neuromodulatory effects of caffeine, vanillin and their combination on some hippocampal biochemical parameters in AlCl3-induced AD. Thirty-six (36) adult male Wistar rats (150–200 g) were randomly divided into 6 treatment groups of 6 rats each. Animals were exposed to AlCl3 (100 mg/kg body weight, bw) orally at a single dose to induce AD. Experimental AlCl3-induced animals were administered with 50 mg/kg bw caffeine, vanillin and their combination for 21 days with donepezil (10 mg/kg bw) as control. However, following the 21 days treatment with 50 mg/kg caffeine, vanillin and their combination, a noticeable significant (p < 0.05) decrease was observed in the hippocampal ENTPDase activity with a concomitant increase significantly (p < 0.05) in eNTDase activity, respectively. Also, a significant (p < 0.05) reduction was evident in the hippocampal relative mRNA gene levels of eNOS, AChE and β-amyloid protein with no significant difference in the expression of GABA receptor protein in some treatment groups compared to untreated AlCl3-induced control group. Similarly, hippocampal architecture revealed restoration of dentate gyrus with an increased granular cell counts after the 21 days of treatment. Thus, according to our findings, the ability of caffeine, vanillin and their combination to modulate hippocampal purinergic system and expressions of some vital proteins in AlCl3-induced AD could possibly be a potential therapy in the management of AD.
Outcomes of parenteral nutrition in patients with advanced cancer and malignant bowel obstruction
Authors: Velasquez David A. , Dhiman Ankit , Brottman Colette , Eng Oliver S. , Fenton Emily , Herlitz Jean , Lozano Edward , McDonald Edwin , Reynolds Valerie , Wall Elizabeth , Whitridge Jeffrey , Semrad Carol , Turaga Kiran , Micic Dejan 
Published: November 2023

Abstract
Background
Malignant bowel obstruction (MBO) affects 3–15% of all cancer patients. In patients with advanced cancer and inoperable MBO, the average survival varies between four to nine weeks. Parenteral nutrition (PN) may improve survival in specific patient populations with malignant bowel obstruction.
Aims
This retrospective, single-center cohort study aimed to review individual patient outcomes on PN in the setting of advanced cancer with a diagnosis of MBO and identify clinical and laboratory markers predictive of short- and long-term survival to further highlight patients that would benefit from PN in the setting of an inoperable MBO.
Results
In a retrospective analysis of 68 patients receiving PN for inoperable MBO, the median survival was 142 (IQR: 63.3-239.5) days. Patients experienced a median number of two hospital readmissions (range: 0–10) and spent a median of 29 days (range: 0-105) in the hospital after starting PN. Eighteen (26.5%) patients developed a catheter-related bloodstream infection (CRBSI). A diagnosis of appendiceal cancer was identified as a predictive marker of improved survival (HR: 0.53, 95% CI: 0.29–0.92, p = 0.023).
Conclusions
The use of PN in the context of end-of-life cancer care is a practice that necessitates improvement. Recognizing the outcomes and patient experiences of PN utilization is essential to physicians and patients.
A rare co-occurrence of invasive mucinous adenocarcinoma, unilateral renal agenesis, and bicornuate uterus: Is it a new triad?
Authors: Mbwambo Orgeness Jasper , Anthony Jonaviva , Mremi Alex , Ngowi Nicholas B. , Mvunta David H. 
Published: November 2023

Abstract
Background
Concomitant invasive mucinous adenocarcinoma, unilateral renal agenesis and bicornuate uterus is a rare combination. Unilateral renal agenesis has been associated with genital anomalies, such as unicornuate and bicornuate uterus. Furthermore, a wealth of studies has reported the association between unicornuate uterus and ovarian anomalies, such as the absence of an ovary or ectopic ovaries, but rarely has there been a combination of the three to the best of our knowledge. The present case report is the first case presentation with a combination of the three syndromes: ovarian mucinous tumor, unilateral renal agenesis, and bicornuate uterus.
Case Presentation:
We report the case of a 17-year-old who presented with abdominal distension. On examination, a CT scan revealed a large multicystic abdominal mass on the right side, with an absence of the right kidney while the left kidney was normal in size, appearance, and position. Intraoperatively, massive blood-stained ascitic fluid was evacuated. Additionally, a large whitish polycystic intra-abdominal mass with mucus-like materials and solid areas was attached to the midpoint of the colon and the right ovary, with visible metastasis to the omentum. The uterus was bicornuate. The mass and omentum were taken for histopathology and a diagnosis of invasive mucinous cystadenocarcinoma with metastasis to the colon and omentum was made after a pathological report.
Conclusions
The presence of these conditions in the same individual could potentially complicate medical management and fertility considerations. Thus, a need for a multidisciplinary medical team, including gynecologists, urologists, and oncologists, to address their unique needs and provide appropriate treatment and guidance. Further research and case studies are needed to better understand the possible association and implications of these rare co-occurring conditions.
Removal of fluoride ions from aqueous solutions on unmodified and iron-modified hydrogels
Authors: Rosendo-González Veronica , Gutiérrez-Segura Edith Erielia , Solache-Rios Marcos , Amaya-Chavez Araceli 
Published: November 2023

Abstract

Unmodified and iron-modified hydrogels were synthesized from polyvinyl alcohol and polyvinylpyrrolidone; these materials were used for the adsorption of fluoride ions from an aqueous solution. The structural and morphological characteristics of the unmodified (HG) and modified (HG-Fe) hydrogels were determined by means of hydration percentage, point of zero charge (PZC), infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and dispersive energy spectroscopy (EDS). The parameters considered in the adsorption processes were contact time, pH, fluoride concentration and dosage. The kinetic data were obtained at an initial pH of 6.7 and were best fitted to the Elovich model (R2 = 0.994); the adsorption capacity was higher for HG-Fe than HG. The data obtained at pH 5 were adjusted to the Lagergren equation indicating physical adsorption. The capacities of both materials (HG and HG-Fe) were similar, and the equilibrium time was shorter for HG than HG-Fe. The isotherms were best fitted to the Langmuir model, indicating homogeneous materials. The maximum adsorption capacities were similar for both adsorbents (HG-Fe and HG), and the thermodynamic parameters showed that the processes are exothermic.
Advancing the Boundary of Pre-trained Models for Drug Discovery:Interpretable Fine-Tuning Empowered by Molecular Physicochemical Properties
Authors: Pan Xiang , Lian Xiaoqing , Zhu Jie , Lv Tianxu , Hong Xiaoyan , Ding Longzhen , Li Lihua , Jiang Chunjuan , Ni Jianming 
Published: November 2023

Abstract
The field of drug discovery has seen the emergence of several pre-trained models that exhibit exceptional performance across a range of downstream tasks. However, these pre-trained models resulting with large models and black-box models, which often break down when predicting data for which limited supervised information is available and lack interpretability, still is a major barrier for transformation integration of drug discovery. This paper pushes the boundaries of pre-trained models in the realm of drug molecules by introducing a novel fine-tuning framework known as the Head Feature Parallel Adapter (HFPA), which is designed to be highly interpretable, high-performing, and minimal parameters. Specifically, Our fine-tuning approach partitions the pre-trained model's general chemical feature space into specific molecular physicochemical property feature spaces. Adapter modules with minimal parameters are introduced for each of these spaces, enabling focused exploration of atomic and chemical bond knowledge. The specialized feature spaces are then recombined into the original chemical feature space size, enhancing the model's interpretability through fine-grained feature acquisition. Furthermore, our work offers comprehensive interpretability analysis for hyperparameter selection, providing valuable insights to guide chemists in understanding specific physicochemical properties of molecules. We conducted an extensive series of experiments that demonstrated the superiority of our approach. It outperformed other fine-tuning methods in seven physiology and toxicity prediction tasks. Furthermore, to explore the generalization capability of HFPA on different types of tasks, we also tested it on three physical chemistry tasks, achieving state-of-the-art results.
Decoding peanut smut: A bibliometric analysis of two decades of research progress
Authors: Cazón Luis Ignacio , Paredes Juan Andrés , Miretti Esteban , Gonzalez Noelia , Suarez Lautaro , Conforto Cinthia , Rago Alejandro Mario 
Published: November 2023

Abstract

Since its first report in commercial peanut fields in 1995, the prevalence and yield impact caused by peanut smut disease have rapidly increased. Simultaneously, various research groups have studied this pathosystem using different approaches, contributing to the scientific understanding of the disease. Recognizing the importance of a comprehensive bibliographic review and organized information, this work aims to provide a thorough scientometric analysis of the evolution of peanut smut research from its inception to the present day. To achieve this goal, bibliographic data about the disease were compiled, and metrics were calculated. The analysis revealed that a smaller proportion of the scientific production was published in peer-reviewed journals, with epidemiology and breeding being the predominant topics. Collaborative efforts played a pivotal role in advancing the study of this pathosystem. The research also identified the researchers with the most significant presence in the publications, the institutions involved, and the impact of the papers produced, among other trends. Despite significant scientific and technological advances in peanut smut research, these advances are not adequately represented in peer-reviewed journals, presenting a challenge for researchers in this field. It is crucial to continue generating knowledge to contribute to the integrated management of this complex pathosystem, preventing further yield losses and the pathogen's spread to new production areas.