bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of anti‐SAE1/2 antibody–positive dermatomyositis with extensive panniculitis: A possible cutaneous manifestation of treatment resistance
Authors: Fujisaki Misako , Kasamatsu Hiroshi , Nishimura Kentarou , Yoshida Yasuyuki , Muneishi Yoriko , Yamaguchi Tomohisa , Nishino Ichizo , Konishi Risa , Ichimura Yuki , Okiyama Naoko , Oyama Noritaka , Hasegawa Minoru 
Published: October 2023

AbstractDermatomyositis constitutes a heterogeneous group of autoimmune inflammatory conditions with a wide variety of clinical outcomes. The symptomatic heterogeneity carries skin, muscle, and joint manifestations; pulmonary and cardiac involvements; and concomitant malignancy. Any of these symptoms often appear at different combinations and time courses, thus posing difficulty in early diagnosis and appropriate treatment choice. Recent progress in laboratory investigations explored the identification of several myositis‐specific autoantibodies (MSAs) and myositis‐associated autoantibodies, allowing precise characterization for a clinical perspective of the disease. MSAs can be detectable in approximately 80% of patients with whole dermatomyositis, some of which closely reflect unique clinical features in the particular disease subset(s), including the distribution and severity of organ involvement, treatment response, and prognosis. However, only limited evidence has been available in dermatomyositis‐associated panniculitis, mostly that in anti‐ melanoma differentiation‐associated protein 5 antibody–positive disease. We present a rare case of a patients with dermatomyositis with extensive panniculitis on the trunk whose serum IgG autoantibodies reacted with both subunits of small ubiquitin‐like modifier activating enzymes (SAEs), SAE1 and SAE2. The onset of panniculitis coincided with increased disease activity, including disease‐related skin manifestations, fever, dysphagia, and muscle weakness in the extremities. These symptoms responded well to a high dose of systemic steroid, but even upon receiving a high‐dose intravenous immunoglobulin, the panniculitic lesions and pruritic erythema flared with tapering of steroid dose, further requiring tacrolimus and mycophenolate mofetil to achieve disease remission. To our knowledge, this is the third reported case of anti‐SAE autoantibody–positive dermatomyositis with panniculitis. We aim to extend the understanding of the current limitation and further perspective in the clinical management of the extremely rare skin manifestation associated with dermatomyositis.
Population‐based patient‐reported quality of life outcomes following low‐dose‐rate versus high‐dose‐rate brachytherapy monotherapy for low‐intermediate risk prostate cancer
Authors: Ong Wee Loon , Evans Melanie , Papa Nathan , Williams Scott , Millar Jeremy 
Published: October 2023

AbstractIntroductionTo evaluate patient reported quality of life outcomes (QoL) following low‐dose‐rate brachytherapy (LDR‐BT) and high‐dose‐rate brachytherapy (HDR‐BT) monotherapy for prostate cancer at a population‐based setting.MethodsThe study comprised men with low‐intermediate risk prostate cancer in the Prostate Cancer Outcomes Registry Victoria (PCOR‐Vic), who were treated with LDR‐BT or HDR‐BT monotherapy between 2015 and 2020 and completed the Expanded Prostate Cancer Index Composite (EPIC‐26) questionnaire 12‐month post‐treatment. Men who had ADT were excluded (n = 12). Differences in substantial symptoms (i.e. ‘moderate’ or ‘big’ problem on a 5‐point Likert scale) between LDR‐BT and HDR‐BT arms were evaluated using Pearson's chi‐squared test. Multivariable linear regressions were used to estimate differences in EPIC‐26 urinary, bowel and sexual functional domain scores between LDR‐BT and HDR‐BT arms.ResultsOverall, 198 men were included in this study, of which 167 (84%) had LDR‐BT and 31 (16%) had HDR‐BT. 9 (4.6%), 10 (5.1%) and 56 (28%) reported substantial symptoms for overall urinary, bowel and sexual function at 12‐month post‐treatment, with no significant difference between LDR‐BT and HDR‐BT arms. The adjusted mean differences in urinary incontinence, urinary obstructive, bowel and sexual function domain scores between LDR‐BT and HDT‐BT were: −3.53 (−8.21 to 1.14), −1.27 (−6.88 to 4.35), −0.01 (−5.63 to 5.63) and −8.68 (−21.44 to 4.07) respectively – these were not statistically significant and did not meet the minimal clinically important difference.ConclusionThis is the first Australian population‐based study comparing QoL in men who had LDR‐BT and HDR‐BT, with no statistically or clinically significant differences in QoL observed at 12‐month post‐treatment.
Editorial: Unravelling the fibres—low dietary fibre may lower risk of developing IBD
Authors: Lopes Emily Walsh , Khalili Hamed 
Published: October 2023

LINKED CONTENTThis article is linked to Deng et al papers. To view these articles, visit https://doi.org/10.1111/apt.17649 and https://doi.org/10.1111/apt.17730
Letter: Rethinking the lower incidence of HCC in HIV‐infected patients— A closer look at confounding factors
Authors: Shao Guang‐Zhao , Zhang Wei , Wu Yi‐Fan , Fan Zhong‐Qi , Yang Tian , Lv Guo‐Yue 
Published: October 2023

LINKED CONTENTThis article is linked to Lui et al papers. To view these articles, visit https://doi.org/10.1111/apt.17654 and https://doi.org/10.1111/apt.17713
Tail regeneration at different ontogenetic stages of the tiger salamander Ambystoma tigrinum suggests possible changes in regeneration between larval and metamorphic individuals
Authors: Bothe Vivien , Fröbisch Nadia B. 
Published: October 2023

AbstractUrodele amphibians possess remarkable regenerative abilities, allowing them to rebuild lost body parts. Contrary to lizards, salamanders can fully restore their tails, including the neural spine and components of the vertebral column. The axolotl (Ambystoma mexicanum) is the vertebrate model organism for regeneration research due to its ease of breeding in captivity. However, axolotls are paedomorphic, retaining larval somatic features throughout adulthood and do not naturally undergo metamorphosis, a transition phase from aquatic larvae to terrestrial adults with profound morphological and physiological changes. We investigate the influence of metamorphosis on salamander tail regeneration after conspecific biting in the metamorphosing sister taxon Ambystoma tigrinum using histological analysis to answer two key questions: (1) Does regeneration continue during metamorphosis, or is it halted? (2) How does regeneration differ histologically among larval, metamorphosing and postmetamorphic individuals? Our findings demonstrate that regeneration continues even during metamorphic climax, indicating the simultaneous coordination of metamorphosis and regeneration. Additionally, notable distinctions were observed between developmental stages concerning the speed of regeneration and structural differences in the formation of an apical epithelial cap (AEC). While the approach taken in this study necessarily restricts sample size, it offers valuable insights into regeneration in a metamorphosing species under natural conditions.
Perforating lichen nitidus in the setting of atopic dermatitis
Authors: Gustafson David , Wolf John E. , Lester Laura , Sander Hans 
Published: October 2023

AbstractPerforating lichen nitidus is a rare subtype of lichen nitidus, with approximately 11 cases reported worldwide. Lesions typically present in young male patients at sites prone to mechanical irritation, including the hands, feet, forearms, elbows, and knees. Classic histopathologic features of perforating lichen nitidus show a lymphohistiocytic infiltrate within the papillary dermis between hyperplastic rete ridges with transepidermal elimination of dermal contents. Very few cases are reported in the literature of lichen nitidus and its association with atopic dermatitis. This is the first case describing perforating lichen nitidus in a patient with a history of atopic dermatitis being treated with dupilumab injections. Lesions of perforating lichen nitidus worsened with successful treatment of atopic dermatitis. These findings suggest a unique pathophysiology of perforating lichen nitidus lesions.
Beyond Personalization: Embracing Democratic Learning Within Artificially Intelligent Systems
Authors: Kucirkova Natalia , Leaton Gray Sandra 
Published: October 2023

AbstractThis essay explains how, from the theoretical perspective of Basil Bernstein's three “conditions for democracy,” the current pedagogy of artificially intelligent personalized learning seems inadequate. Building on Bernstein's comprehensive work and more recent research concerned with personalized education, Natalia Kucirkova and Sandra Leaton Gray suggest three principles for advancing personalized education and artificial intelligence (AI). They argue that if AI is to reach its full potential in terms of promoting children's identity as democratic citizens, its pedagogy must go beyond monitoring the technological progression of personalized provision of knowledge. It needs to pay more careful attention to the democratic impact of data‐driven systems. Kucirkova and Leaton Gray propose a framework to distinguish the value of personalized learning in relation to pluralization and to guide educational researchers and practitioners in its application to socially just classrooms.
Viruliferous and non‐viruliferous aphids behave differently to enhance the spread of the virus
Authors: Warnasooriya P. G. A. S. , Balagalla Dineesha N. , Jayasinghe Wikum H. 
Published: October 2023

AbstractPlant viruses can modulate insect vector behaviour directly and/or indirectly by altering plant biochemistry. In many instances, such behavioural alterations increase the frequency of encounters between host and vector, leading to enhanced virus dispersal in ecosystems. In the current study using Cucumber mosaic virus (CMV), Capsicum annuum L. (Solanaceae), and Myzus persicae (Sulzer) (Hemiptera: Aphididae) as a pathosystem, we evaluated the direct and indirect effects of CMV on M. persicae biology and behavioural responses. Data showed that CMV indirectly modulates the aphid vector by providing fitness benefits to aphids, leading to enhanced aphid reproduction on CMV‐infected pepper plants in comparison with non‐infected C. annuum plants. Furthermore, CMV can also alter aphid behaviour directly by modulating the behavioural response of viruliferous aphids towards non‐infected plants. We demonstrate that CMV directly and indirectly modulates the insect vector thereby enhancing its transmission in agroecosystems.
The spatial patterns of community composition, their environmental drivers and their spatial scale dependence vary markedly between fungal ecological guilds
Authors: Odriozola Iñaki , Martinović Tijana , Mašínová Tereza , Bahnmann Barbara Doreen , Machac Antonín , Sedlák Petr , Tomšovský Michal , Baldrian Petr 
Published: October 2023

AbstractAimHow community composition varies in space and what governs the variation has been extensively investigated in macroorganisms. However, we have only limited knowledge of microorganisms, especially fungi, despite their ecological and economic significance. Based on previous research, we define and test a series of hypotheses regarding the composition of fungal communities, their most influential drivers and their spatial scale dependence.LocationCzech Republic.Time periodPresent.Taxa studiedFungi.MethodsWe analysed the distance decay relationships, community composition and its drivers (physical distance, litter and soil chemistry, tree composition and climate) in fungi using multivariate analyses. We compared the results across three fungal ecological guilds (ectomycorrhizal fungi, saprotrophs and yeasts), two forest microhabitats (litter and bulk soil) and six spatial scales (from 5 m to 80 km) that comprehensively cover the Czech Republic.ResultsWe found that, similar to macroorganisms, the ectomycorrhizal fungi and saprotrophs showed marked distance–decay relationships, and their community composition was driven mainly by vegetation and dispersal at local scales but, at regional scales, by environmental effects. In contrast, the third fungal guild, the unicellular yeasts, showed little distance decay, suggesting extraordinary spatial homogeneity, as often seen in microorganisms, such as bacteria.Main conclusionsOur results underscore the remarkable variation in the community ecology of fungi, which seems to range well‐known patterns both from the macro‐ and the microworld. Knowledge of these patterns advances our understanding of the ecology of fungi, rather understudied organisms of significant ecological and economic importance, which our findings identify as a potentially suitable model for bridging the gaps between the biogeography of micro‐ and macroorganisms.
Effect of driving training on car crashes and driving skills in older people: A systematic review and meta‐analysis
Authors: Ishii Hideaki , Okubo Yoshiro , Doi Takehiko , Tsutsumimoto Kota , Nakakubo Sho , Kurita Satoshi , Uemura Kazuki , Misu Shogo , Sawa Ryuichi , Hashiguchi Yu , Shimada Hiroyuki , Arai Hidenori 
Published: October 2023

The primary aim of this systematic review was to examine the efficacy of driving interventions with regard to a reduction in motor vehicle crashes and improvements in driving skills among older people. The secondary aim was to identify the optimal type (on‐road or off‐road) and dosage (period, sessions, and duration) of driving interventions for improving driving skills in older people. We searched MEDLINE, EMBASE, PsycINFO, and Scopus of Systematic Reviews for papers published from their inception to December 1, 2020, as well as the reference lists of the included papers. The selected studies were randomized controlled trials examining the effects of driving interventions among community‐dwelling older drivers aged 65 years and over. A meta‐analysis of two studies (n = 960) showed that driving interventions significantly reduced the number of motor vehicle crashes per person‐years. Ten studies (n = 575) were included in the meta‐analysis showing that the interventions significantly improved the driving skill scores. Driving skill scores significantly improved after on‐road training, and in interventions of at least 3 h, 3 sessions, and 3 weeks. Driving interventions significantly improve driving skills and reduce motor vehicle crashes among older drivers aged 65 years and over. On‐road training is more efficacious than off‐road training and driving interventions of at least 3 h taking place in 3 sessions over a period of 3 weeks may be required to improve driving skills in older drivers. Geriatr Gerontol Int 2023; 23: 771–778.
Organizational response to the COVID‐19 pandemic and its association with moral distress in community mental health teams in the UK: A qualitative study
Authors: Wall Abbie , Burton Leanne , Perkins Elizabeth 
Published: October 2023

AbstractIn March 2020, Coronavirus‐19 (COVID‐19) rapidly spread across the globe impacting the mental health of the population and putting an overwhelming pressure on health services. Much has been written about the impact of the pandemic on health‐care workers working in hospital settings but less attention has been paid to its effect on community mental health teams (CMHTs). This study is based on 21 remote interviews with community mental health professionals during the first wave of the COVID‐19 pandemic. Interviews were transcribed and analysed using a thematic analysis whereby codes of similar meaning were grouped into main themes. Analysis identified three major contributors to moral distress; changes in the nature of contact with service users, changes to the place of work, and difficulties of balancing risks to the families of CMHT staff and service users. This study demonstrates that necessary organizational changes instituted to minimize the spread of COVID‐19, required different ways of working which were not perceived to be in the best interests of service users or the families of CMHT staff. In order to comply with Government directives, CMHT staff were forced to behave in a way which did not match their moral values causing them to experience moral distress.
Toward COVID‐19 recovery: Advanced practice nurse leadership in rural Vermont
Authors: Whitfield Martha M. , Wohlberg Jeri , Costa Michael 
Published: October 2023

AbstractAimTo reflect on the inclusion of an advanced practice nurse (APN) on a clinical leadership team in rural Vermont during the COVID‐19 pandemic.BackgroundDuring the COVID‐19 pandemic, APNs contributed to the reimagining of healthcare delivery. In response to pandemic‐related organizational needs, one rural health center in Vermont promoted an APN to a leadership position.Sources of evidenceThis critical reflection describes the experience of one APN promoted to a clinical leadership role during the COVID‐19 pandemic in rural Vermont in the United States. We use the four stages of crisis (escalation, emergency, recovery, and resolution) and the healthcare leadership framework proposed by Geerts et al. (2021) to consider how APN leaders can contribute in the “recovery stage” of the pandemic.DiscussionAPNs who took on leadership roles during the pandemic may have had fewer opportunities to participate in formal leadership development. However, in the case of our rural health center, an APN was able to seek out mentorship, address operational challenges, and provide representation for advanced practice providers.ConclusionThis article contributes to the literature on APN leadership during the COVID‐19 pandemic, by describing a leadership opportunity that helped build APN leadership capability and capacity in our organization.Implications for nursing practiceAPNs offer a valuable perspective on health leadership teams. As organizations move toward the recovery stage of the pandemic, different leadership styles and skills may be required.Implications for health policyThe COVID‐19 pandemic provided unexpected leadership opportunities for APNs. Healthcare organizations now have opportunities to reimagine clinical leadership in ways that include APNs.
Effect of two different laparoscopic techniques on post‐operative wound complications in patients with benign gynaecological diseases: A meta‐analysis
Authors: He Haining , Li Tinglan , Cui Manman , Jiang Qin , Jiang Fuchuan , Li Min , Liu Yi 
Published: October 2023

AbstractSingle‐port laparoscopy (SPL) has existed for several years. This meta‐analysis was conducted to evaluate the efficacy of SPL compared with conventional laparoscopy (CL) in the treatment of benign gynecologic adnexal lesions. The purpose of this meta‐analysis is to evaluate the superiority of SPL versus CL in the treatment of post‐operative wound pain. The study looked for English‐language publications from PubMed, Embase, Cochrane Library and the Web of Science until June 2023. The main result was the visual analogue scale (VAS) after 2, 4, 6, 8, 12, 24 and 48 h after operation. The paper contains 10 related papers by means of e‐search. Of these, 4 were randomized controlled trials (RCTs), while 6 were non‐RCTs. The results indicated that SPL and CL were significantly different after 2, 24 and 48 h after operation. SPL had lower post‐operative pain after 2 h compared with CL (MD, −0.6; 95% CI, −0.98, −0.21; p = 0.002). After the operation, SPL also had a lower incidence of post‐operative pain after 24 h compared with CL (MD, −0.59; 95% CI, −1.12, −0.06; p = 0.03). And the difference in pain was at 48 h after the most significant (MD, −0.49; 95% CI, −0.75, −0.23; p = 0.0002). But after 6, 8 and 12 h after operation, there was no significant difference in the degree of pain. Thus, SPL operations may result in a lower degree of pain than CL in both the post‐operative and far post‐operative phase.
ELP2‐NLRP3‐GSDMD/GSDME‐mediated pyroptosis is induced by TNF‐α in MC3T3‐E1 cells during osteogenic differentiation
Authors: Xia Changliang , Ou Shuanji , Yang Yang , Zhang Wei , Wu Wenjiao , Chen Qi , Li Wenjun , Lu Hanyu , Wang Yeyang , Qi Yong , Xu Changpeng 
Published: October 2023

AbstractTumour necrosis factor‐α (TNF‐α) is a cytokine involved in systemic inflammation. TNF‐α slows down osteogenic differentiation, which may contribute to poor bone development in the inflammatory microenvironment. TNF‐α inhibits osteogenic differentiation by activating the JAK‐STAT3 pathway, of which Signal transducer and activator of transcription 3 (STAT3)‐interacting protein 1 (StIP1, also known as elongator complex protein 2, ELP2) is a key protein in the JAK‐STAT3 pathway. We investigated whether and how ELP2 activation mediates the TNF‐α‐induced pyroptosis during osteoblastic differentiation. Using in vitro cell cultures of preosteoblastic MC3T3‐E1 cells, we found that TNF‐α exposure causes cell pyroptosis in an inflammatory microenvironment during osteoblastic differentiation. Bioinformatics, protein docking model and co‐immunoprecipitation analysis revealed an association between ELP2, STAT3 and NLRP3. Forced ELP2 expression promoted MC3T3‐E1 cells pyroptosis, with an increase in the expression of STAT3, NLRP3 inflammasome, GSDMD/GSDME, osteoblast marker genes, and the activity of alkaline phosphatase. In contrast, ELP2 silencing ameliorated MC3T3‐E1 cells pyroptosis, and osteogenic differentiation, especially after TNF‐α stimulation. The TNF‐α‐induced cells pyroptosis during osteoblastic differentiation was therefore mediated by ELP2. These results suggest that ELP2 is upregulated at the pyroptosis of MC3T3‐E1 cells and inhibits osteogenic differentiation in response to TNF‐α through NLRP3‐GSDMD/GSDME activation.
KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m6A‐dependent posttranscriptional modification of SLC7A11
Authors: Wang Houhong , Chen Wenli , Cui Yayun , Gong Huihui , Li Heng 
Published: October 2023

AbstractN6‐methyladenosine (m6A) modification represents the most abundant internal methylation of eukaryotic RNAs. KIAA1429 acts as a key component of the m6A methyltransferase complex, but its function and mechanism in ferroptotic cell death of hepatocellular carcinoma (HCC) are barely defined. We found that KIAA1429 suppression triggered ferroptosis in HCC cells according to increased cell death, iron and MDA levels, C11‐BODIPY‐positive cells, ROS production and decreased GSH level. Ferroptosis inhibitors ferrostatin‐1 (0.5 μM) and liproxstatin‐1 (10 μM) blocked KIAA1429 suppression‐induced ferroptosis of HCC cells. In addition, overexpressed KIAA1429 notably heightened the activity of cystine/glutamate antiporter (SLC7A11). SLC7A11 up‐regulation partially hindered KIAA1429 inhibition‐mediated ferroptosis of HCC cells. The regulation SLC7A11 by KIAA1429 was attenuated by global m6A inhibitor cycloleucine (40 μM). RNA immunoprecipitation confirmed the binding of KIAA1429 to m6A on SLC7A11 transcript. Additionally, it was proven that KIAA1429 inhibition mitigated HCC growth in subcutaneous xenograft mice through SLC7A11. Altogether, our findings first propose that KIAA1429 protects HCC cells from ferroptosis with a m6A‐dependent post‐transcriptional modification of SLC7A11 and offer a novel insight into the dysregulated epi‐transcriptomics in the context of HCC.