bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Enantioselective Friedel—Crafts Alkylations of Pyrroles and Indoles with α′‐Hydroxy Enones under Cu(II)‐Simple Bis(oxazoline) Catalysis.
Authors: Palomo Claudio , Oiarbide Mikel , Kardak Bharat G. , Garcia Jesus M. , Linden Anthony 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1,2,3,9a‐Tetrahydro‐9H‐imidazo[1,2‐a]indole‐2‐thione and 1,5,6,10b‐Tetrahydroimidazo[2,1‐a]isoquinoline‐2(3H)‐thione Derivatives
Authors: Valaityte E. , Martynaitis V. , Sackus A. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantio‐ and Diastereoselective Additions to Aldehydes Using the Bifunctional Reagent 2‐(Chloromethyl)‐3‐(tributylstannyl)propene: Application to a Synthesis of the C16—C27 Segment of Bryostatin 1.
Authors: Keck Gary E. , Yu Tao , McLaws Mark D. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Stille Cross‐Coupling Reaction Catalyzed by the Pd(OAc)2/Dabco Catalytic System.
Authors: Li Jin‐Heng , Liang Yun , Wang De‐Ping , Liu Wen‐Jie , Xie Ye‐Xiang , Yin Du‐Lin 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Convenient Palladium Catalyzed Synthesis of Symmetric Biaryls, Biheterocycles and Biaryl Chiral Diamides.
Authors: Goswami Shyamaprosad , Adak Avijit Kumar , Mukherjee Reshmi , Jana Subrata , Dey Swapan , Gallagher John F. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regiocontrolled Benzannulation of Diaryl(gem‐dichlorocyclopropyl)methanols for the Synthesis of Unsymmetrically Substituted α‐Arylnaphthalenes: Application to Total Synthesis of Natural Lignan Lactones.
Authors: Nishii Yoshinori , Yoshida Taichi , Asano Hirofumi , Wakasugi Kazunori , Morita Jun‐ichi , Aso Yoshifumi , Yoshida Eri , Motoyoshiya Jiro , Aoyama Hiromu , Tanabe Yoo 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Atom‐Economic, Solvent‐Free, High Yield Synthesis of 2‐(Pyrrol‐1‐yl)propyldiorganylphosphines.
Authors: Trofimov Boris A. , Gusarova Nina K. , Sukhov Boris G. , Malysheva Svetlana F. , Tarasova Olga A. , Belogorlova Natalya A. , Maximova Marina A. , Tunik Sergey P. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective Cyclization of Unsymmetrical Dicyanoanilines to Novel 2,3‐Bifunctionalized Indole Regioisomers and Their Use in the Synthesis of 4,5‐Dihydro[1,3]oxazino[5,4‐b]indole‐6‐carbonitriles.
Authors: Maitraie D. , Reddy G. Venkat , Rao V. V. V. N. S. Rama , Ravikanth S. , Narsaiah B. , Rao P. Shanthan , Ravikumar K. , Sridhar B. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemoselective Reaction of Benz[g]indole Dicarboxylate Towards Hydrazine Hydrate: Bisheterocycles: Synthesis and Antimicrobial Activity of Some New 1‐[2‐Hydroxyethyl] ‐3‐ethoxycarbonyl‐5‐oxadiazolyl/triazolyl/pyrrolylaminocarbonylmethoxy‐2 ‐methylbenz[g]indoles.
Authors: Bhovi Manjunath G. , Gadaginamath Guru S. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Fluoroalkyl‐Containing 1,2,3‐Triketone 2‐Hetarylhydrazones and Their Reactions with Hydrazines.
Authors: Shchegol'kov E. V. , Burgart Ya. V. , Khudina O. G. , Saloutin V. I. , Chupakhin O. N. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimicrobial Activity of Some 5‐[2‐(Morpholin‐4‐yl)acetamido] and/or 5‐[2‐(4‐Substituted piperazin‐1‐yl)acetamido]‐2‐(p‐substituted phenyl)benzoxazoles.
Authors: Temiz‐Arpaci Oezlem , Oezdemir Aliye , Yalcin Ismail , Yildiz Ilkay , Aki‐Sener Esin , Altanlar Nurten 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Substituted Tetrahydropyrones from Hetero‐Diels—Alder Reactions of 2‐Alkenals with Stereochemical Induction from Chiral Dienes.
Authors: Ruijter Eelco , Schueltingkemper Heike , Wessjohann Ludger A. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Synthetic Approach to Substituted Isoindolo[2,1‐a]quinoline Carboxylic Acids via Intramolecular Diels—Alder Reaction of 4‐(Furyl‐2)‐4‐arylaminobutenes‐1 with Maleic Anhydride.
Authors: Zubkov Fedor I. , Boltukhina Ekaterina V. , Turchin Konstantin F. , Borisov Roman S. , Varlamov Alexey V. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Magnesium Chloride Hexahydrate Catalyzed One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2‐(1H)‐ones under Solvent‐Free Conditions.
Authors: Zhang Guo‐Lin , Cai Xiao‐Hua 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Structures of Spiro‐σ‐Complexes Based on 2‐(2‐Benzylaminophenyl)5,6‐dimethylbenzimidazole.
Authors: Morozov P. G. , Kurbatov S. V. , Dolgushin F. M. , Antipin M. Yu. , Olekhnovich L. P. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Synthesis and Antibacterial Activity of 15‐Iminobenzothiazolo[2,3‐b]pyrimido[5,6‐e]pyrimido [2,3‐b]benzothiazol‐14(H)‐one and Its 3,10‐Disubstituted Derivatives.
Authors: Baheti K. G. , Jadhav J. S. , Suryavanshi A. T. , Kuberkar S. V. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of Novel Derivatives of Spiro‐[6H‐indolo[2,1‐b]quinazoline‐6,3′‐[1,2,4]oxadiazoline].
Authors: Azizian Javad , Madani Masoud , Souzangarzadeh Saeid 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective One‐Pot Synthesis of 9‐Alkyl‐6‐chloropyrido[3,2‐e][1,2,4]triazolo[4,3‐a]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides.
Authors: Unciti‐Broceta Asier , Pineda‐de‐las‐Infantas Maria J. , Diaz‐Mochon Juan J. , Romagnoli Romeo , Baraldi Pier G. , Gallo Miguel A. , Espinosa Antonio 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Structures of Pyridoanellated 1,2,3,4‐Tetrazine 1,3‐Dioxides.
Authors: Tartakovsky V. A. , Filatov I. E. , Churakov A. M. , Ioffe S. L. , Strelenko Yu. A. , Kuz'min V. S. , Rusinov G. L. , Pashkevich K. I. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Silicon‐Induced Diastereoselectivity of the Catalyzed Phosphorylation of 1‐(Perfluoroalkyl)‐ω‐(trialkylsilyl)alkan‐1‐ols.
Authors: Molchanova G. N. , Shcherbina T. M. , Petrovskii P. V. , Kudryavtsev I. Yu. , Zakharov L. S. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of O‐Phenylchloromethylthiophosphonyl Isothiocyanate with Dicyanomethane.
Authors: Bagautdinova R. Kh. , Khailova N. A. , Kamalov R. M. , Chmutova G. A. , Pudovik M. A. , Pudovik A. N. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lancifodilactone F: A Novel Nortriterpenoid Possessing a Unique Skeleton from Schisandra lancifolia and Its anti‐HIV Activity.
Authors: Xiao Wei‐Lie , Li Rong‐Tao , Li Sheng‐Hong , Li Xiao‐Li , Sun Han‐Dong , Zheng Yong‐Tang , Wang Rui‐Rui , Lu Yang , Wang Cheng , Zheng Qi‐Tai 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
2004 Bader Award Lecture Metal‐ion‐catalyzed Acyl and Phosphoryl Transfer Reactions to Alcohols: La3+‐Promoted Alcoholysis of Activated Amides, Carboxylates Esters, and Neutral Organophosphorus Esters
Authors: Brown R. Stan , Neverov Alexei A. , Tsang Josephine S. W. , Gibson Graham T. T. , Montoya‐Pelaez Pedro J. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Functionalization and Synthetic Application of Pyridazin‐3(2H)‐ones
Authors: Kim Sung‐Kyu , Kweon Deok‐Heon , Cho Su‐Dong , Kang Young‐Jin , Park Ki‐Hun , Lee Sang‐Gyeong , Yoon Yong‐Jin 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Heterocyclizations of 3‐Alkynyl‐6,8‐dimethylpyrimido[4,5‐c]pyridazine‐5,7(6H,8H)‐diones and Their Lumazine Analogues
Authors: Gulevskaya Anna V. , Dang Shee Van , Pozharskii Alexander F. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Evaluation of breast cancer with a computer‐aided detection system by mammographic appearance and histopathology
Authors: Brem Rachel F. , Rapelyea Jocelyn A. , Zisman Gilat , Hoffmeister Jeffrey W. , DeSimio Martin P. 
Published: July 2005

AbstractBACKGROUNDThe objective of this study was to evaluate the performance of a computer‐aided detection (CAD) system for the detection of breast cancer, based on mammographic appearance and histopathology.METHODSFrom 1000 consecutive screening mammograms from women with biopsy‐proven breast carcinoma, 273 mammograms were selected randomly for retrospective evaluation by CAD. The sensitivity of the CAD system for breast cancer was assessed from the proportion of masses and microcalcifications detected. The corresponding tumor histopathologies also were evaluated. Normal mammograms (n = 155 patients) were used to determine the false‐positive rate of the system.RESULTSOf the 273 breast carcinomas, 149 appeared mammographically as masses, and 88 appeared as microcalcifications, including 36 carcinomas that presented as mixed lesions. The CAD system marked 125 of 149 masses correctly (84%), marked 86 of 88 microcalcifications correctly (98%), and marked 32 of 36 of mixed lesions correctly (89%.). The system showed a high sensitivity for the detection of ductal carcinoma in situ (95%; 73 of 77 lesions), invasive lobular carcinoma (95%; 18 of 19 lesions), invasive ductal carcinoma (85%; 125 of 147 lesions), and invasive mammary carcinoma (90%; 27 of 30 lesions). The highest CAD system sensitivity was for all invasive carcinomas that presented as microcalcifications (100%). On normal mammograms, there was an average of 1.3 false‐positive CAD marks per image.CONCLUSIONSThe CAD system correctly marked a large majority of biopsy‐proven breast cancers, with a greater sensitivity for lesions with microcalcifications and without significant impact of performance based on tumor histopathology. CAD was highly effective in detecting invasive lobular carcinoma (sensitivity, 95%) and ductal carcinoma in situ (sensitivity, 95%). CAD represents a useful tool for the detection of breast cancer. Cancer 2005. © 2005 American Cancer Society.
MammoSite excision volume as a predictor for residual disease
Authors: Kaufman Seth A. , DiPetrillo Thomas A. , Ruthazer Robin , Wazer David E. 
Published: July 2005

AbstractBACKGROUNDThe MammoSite catheter is a brachytherapy device used for accelerated partial breast irradiation. Currently, it is available as 2 spherically shaped balloons meant to fill 70‐cc and 120‐cc cavity volumes. This study was designed to define the relation of these excision volumes to the likelihood of microscopically detectable, residual disease based on tumor size, margin status, patient age, and histology.METHODSThe study data base was comprised of 531 patients with Stage 0, I, and II breast carcinoma (using American Joint Committee on Cancer staging criteria) who received breast‐conserving therapy and underwent surgical reexcision. Patients in the data base were stratified based on the volume of their initial excision: ≤ 70 cc versus > 70 cc and ≤ 120 cc versus > 120 cc.RESULTSSurgical margin size was found to be a strong predictor of residual disease both for patients with smaller excision volumes (P = 0.0014) and patients with larger excision volumes (P = 0.0003); histology (extensive intraductal component [EIC] or pure ductal carcinoma in situ [DCIS]) also was a strong predictor. Tumor size was significant only for the larger volume group (P = 0.029). On multivariate analysis, only histology and initial margin status were significant correlates with residual disease. The adjusted odds ratio for residual disease with pure DCIS was 0.79, and the adjusted odds ratio for invasive ductal or lobular carcinoma (IDC/ILC) without EIC was 0.44 relative to IDC/ILC with EIC (P = 0.008). The adjusted odds ratio for residual disease with a positive initial margin versus a negative initial margin was 2.65 (P ≤ 0.0001).CONCLUSIONSFor excisions amenable to use of the MammoSite catheter, a margin ≥ 1.0 mm appeared to afford at most a 35% risk of microscopically detectable residual tumor. Evidence of EIC on excision of IDC/ILC connoted a significantly higher risk. Age did not appear to be predictive for residual disease. Cancer 2005. © 2005 American Cancer Society.
Quality of prostate carcinoma care in a statewide public assistance program
Authors: Krupski Tracey L. , Bergman Jonathan , Kwan Lorna , Litwin Mark S. 
Published: July 2005

AbstractBACKGROUNDThe authors evaluated the feasibility of measuring quality of care in a statewide public assistance program for men with prostate carcinoma.METHODSThe sample consisted of 84 men who were followed for ≥ 6 months after receiving primary treatment for early‐stage prostate carcinoma (55 received radical prostatectomy and 29 received radiotherapy) through a free public program for low‐income, uninsured men. Quality was assessed by chart review with 16 indicators previously developed and validated at the RAND Corporation, as well as by telephone and mail surveys that included the University of California at Los Angeles Prostate Cancer Index short form.RESULTSQuality of care measurement was feasible for 13 (81%) indicators from electronic chart abstraction, administrative documents, and patient questionnaires. Communication between specialist and primary physician was better for men treated with radiotherapy than with surgery (84% vs. 45%, P = 0.004). Subjects treated in private institutions were more likely than those treated in public institutions to have ≥ 2 follow‐up visits with the treating physician or institution within 1 year of treatment (93% vs. 63%, P = 0.003) and to have documentation of communication with the primary care physician (90% vs. 40%, P << 0.0001). Disease‐specific, health‐related quality of life 6 months after treatment did not appear to differ between public and private facilities.CONCLUSIONSThe authors found the application of quality of care indicators to be feasible in a statewide public assistance program, but with some differences between public and private providers. These quality of care indicators identified target areas for improvement. Cancer 2005. © 2005 American Cancer Society.
Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation
Authors: Jones Timothy D. , Eble John N. , Wang Mingsheng , MacLennan Gregory T. , Jain Shashi , Cheng Liang 
Published: July 2005

AbstractBACKGROUNDApproximately 5% of clear cell renal cell carcinomas contain components with sarcomatoid differentiation. It has been suggested that the sarcomatoid elements arise from the clear cell tumors as a consequence of clonal expansions of neoplastic cells with progressively more genetic alterations. Analysis of the pattern of allelic loss and X‐chromosome inactivation in both the clear cell and sarcomatoid components of the same tumor allows assessment of the genetic relationship of these tumor elements.METHODSThe authors of the current study examined the pattern of allelic loss in clear cell and sarcomatoid components of renal cell carcinomas from 22 patients who had tumors with both components. DNA samples were prepared from formalin‐fixed, paraffin‐embedded renal tissue sections using laser‐capture microdissection. Five microsatellite polymorphic markers for putative tumor suppressor genes on 5 different chromosomes were analyzed. These included D3S1300 (3p14), D7S522 (7q31), D8S261 (8p21), D9S171 (9p21), and TP53 (17p13). In addition, X‐chromosome inactivation analysis was performed in 14 tumors from female patients.RESULTSThe clear cell components showed loss of heterozygosity (LOH) at the D3S1300, D7S522, D8S261, D9S171, and TP53 loci in 18% (4/22), 18% (4/22), 50% (10/20), 15% (3/20), and 20% (4/20) of informative cases, respectively. LOH in the sarcomatoid components was seen at the D3S1300, D7S522, D8S261, D9S171, and TP53 loci in 18% (4/22), 41% (9/22), 70% (14/20), 35% (7/20), and 20% (4/20) of informative cases, respectively. Six cases demonstrated an LOH pattern in the clear cell component that was not seen in the sarcomatoid component. Different patterns of allelic loss were seen in the clear cell and sarcomatoid components in 15 cases. Clonality analysis showed the same pattern of nonrandom X‐chromosome inactivation in both clear cell and sarcomatoid components in 13 of the 14 cases studied. One case showed a random pattern of X‐chromosome inactivation.CONCLUSIONX‐chromosome inactivation analysis data suggest that both clear cell and sarcomatoid components of renal cell carcinomas are derived from the same progenitor cell. Different patterns of allelic loss in multiple chromosomal regions were observed in clear cell and sarcomatoid components from the same patient. This genetic heterogeneity indicates genetic divergence during the clonal evolution of renal cell carcinoma. Cancer 2005. © 2005 American Cancer Society.
Prognostic significance of the lymphocyte‐to‐neutrophil ratio in percutaneous fine‐needle aspiration biopsy specimens of advanced nonsmall cell lung carcinoma
Authors: Nakahara Yasuharu , Mochiduki Yoshiro , Miyamoto Yoshihiro , Nakahara Yukiko , Katsura Yoshitaka 
Published: July 2005

AbstractBACKGROUNDThe prognostic significance of tumor‐infiltrating lymphocytes (TILs) in surgically resected carcinomas was reported. To apply this to inoperable nonsmall cell lung carcinomas (NSCLC) of Stage IIIB–IV, the authors estimated the occurrence of TILs using percutaneous fine‐needle aspiration biopsy specimens, and tested the validity of this method.METHODSThe authors defined the L‐N index as [LS/(LS + NS) − LB/(LB + NB)], in which LS and NS denoted lymphocyte and neutrophil counts in the aspiration smear, and LB and NB denoted lymphocyte and neutrophil counts in the peripheral blood specimen. The cutoff value was set at twice the standard deviation of the L‐N index of 41 smears contaminated with abundant blood. Retrospectively, the authors compared the survival rate of the group with a high L‐N index (lymphocyte‐dominant group) (n = 12) with the survival rate of the group with a low L‐N index (lymphocyte‐nondominant group) (n = 60). Then, they performed a prospective study and compared the survival rates of these 2 groups (n=21 and n = 54). The Cox proportional hazards model was used to determine the effect of the L‐N index as a continuous variable and other prognostic factors. The correlation (r) between the L‐N index‐based grouping (L‐N grouping) and the histologic grade of TILs was studied among resected lung tumor specimens (n = 164).RESULTSIn the retrospective and prospective studies, the survival rate was significantly higher in the lymphocyte‐dominant group than in the lymphocyte‐nondominant group (P = 0.0019 and P = 0.0001). Using multivariate analysis, the L‐N index was an independent prognostic factor. A significant correlation was noted between L‐N grouping and histologic grade of TILs (r = 0.476).CONCLUSIONSThe L‐N index of aspiration smears was found to be an independent prognostic factor for patients with advanced‐stage NSCLC. L‐N grouping was correlated with the histologic assessment of TILs. Cancer 2005. © 2005 American Cancer Society.
Combined‐modality treatment for isolated recurrences of breast carcinoma
Authors: Hanrahan Emer O. , Broglio Kristine R. , Buzdar Aman U. , Theriault Richard L. , Valero Vicente , Cristofanilli Massimo , Yin Guosheng , Kau Shu‐Wan C. , Hortobagyi Gabriel N. , Rivera Edgardo 
Published: July 2005

AbstractBACKGROUNDIn three prospective, single‐arm studies, the authors previously showed an improved outcome for anthracycline‐naïve patients with isolated sites of recurrent breast carcinoma (BC) who were treated with doxorubicin‐based chemotherapy after local therapy (surgery and/or radiotherapy). In the current report, the initial results are presented from a Phase II trial of docetaxel (100 mg/m2every 21 days for 6 cycles) given after local therapy for recurrent BC (Stage IV BC with no evidence of clinically measurable disease) in patients who received prior adjuvant anthracycline‐based chemotherapy, and the authors provide an update of the 3 previous studies. An analysis of prognostic factors for these patients also is presented.METHODSEligibility criteria for all studies included histologic proof of recurrent BC that had been resected and/or irradiated with curative intent. Survival was calculated using the Kaplan–Meier method. Univariate survival analyses were performed to test for associations between patient characteristics and outcome (log‐rank test). Cox proportional hazards models were used to determine the multivariable correlations between patient characteristics and outcome.RESULTSThe median follow‐up for the docetaxel‐based trial (n= 26 patients) was 45 months. Early outcomes for this study are promising. The median disease‐free survival (DFS) was 44 months, and the 3‐year DFS and overall survival (OS) rates were 58% and 87%, respectively. In the 3 doxorubicin‐based studies, the median follow‐up was 121.5 months for all living patients, and the estimated 20‐year DFS and OS rates were both 26%. On multivariable analysis of patients from all 4 studies, the only significant prognostic factor for DFS and OS (P= 0.0006) was the number of involved axillary lymph nodes at initial diagnosis.CONCLUSIONSA proportion of patients with isolated BC recurrences achieved prolonged DFS with combined‐modality treatment. Patients who receive anthracycline‐based chemotherapy at primary diagnosis may benefit from local treatment followed by docetaxel‐based chemotherapy for isolated recurrences. The only significant independent prognostic factor was the number of involved axillary lymph nodes at initial diagnosis. Cancer 2005. © 2005 American Cancer Society.
Crystallization behavior of neat biodiesel and biodiesel treated with ozonized vegetable oil
Authors: Soriano Nestor U. , Migo Veronica P. , Sato Kiyotaka , Matsumura Masatoshi 
Published: July 2005

AbstractThe utilization of neat biodiesel is limited by its poor low‐temperature flow properties, which are mainly dictated by the lengths of the hydrocarbon chains and the presence of unsaturation. However, the pour point of neat biodiesel prepared from soybean oil, sunflower oil and rapeseed oil can be improved significantly by treatment with small amounts of ozonized vegetable oil. The presence of carbon‐carbon double bonds along the hydrocarbon chains is necessary to make ozonized vegetable oil an effective pour point depressant for fatty acid methyl esters (FAME). Differential scanning calorimetry and polarized light microscopy revealed that ozonized vegetable oil affects both nucleation and crystal growth of FAME and biodiesel. Treatment of biodiesel with ozonized vegetable oil leads to the formation of considerably smaller, but more numerous crystals at subzero temperatures.