bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materials scarcity during the clean energy transition: Myths, challenges, and opportunities
Authors: Ku Anthony Y. , Kocs Elizabeth A. , Fujita Yoshiko , Haddad Andrew Z. , Gray Robert W. 
Published: January 2024

Abstract
Efforts to reach net zero targets by the second half of the century will have profound materials supply implications. The anticipated scale and speed of the energy transition in both transportation and energy storage raises the question of whether we risk running out of the essential critical materials needed to enable this transition. Early projections suggest that disruptions are likely to occur in the short term for select critical materials, but at the same time these shortages provide a powerful incentive for the market to respond in a variety of ways before supply-level stress becomes dire. In April 2023, the MRS Focus on Sustainability subcommittee sponsored a panel discussion on the role of innovation in materials science and engineering in supporting supply chains for clean energy technologies. Drawing on examples from the panel discussion, this perspective examines the myth of materials scarcity, explains the compelling need for innovation in materials in helping supply chains dynamically adapt over time, and illustrates how the Materials Research Society is facilitating engagement with industry to support materials innovation, now and in the future.

Graphical Abstract

Highlights
In this commentary, we examine the myth of materials scarcity, explain the compelling need for innovation in materials in helping supply chains dynamically adapt over time, and show how the materials research community can effectively engage with industry, policymakers, and funding agencies to drive the needed innovation in critical areas.

Discussion
Demand for certain materials used in clean energy technologies is forecasted to increase by multiples of current production over the next decades. This has drawn attention to supply chain risks and has created a myth that we will “run out” out of certain materials during the energy transition. The reality is that markets have multiple mechanisms to adapt over the long-term, and near-term shortages or expectations of shortages provide a powerful incentive for action. In this commentary, we highlight different ways materials innovation can help solve these issues in the near term and long term, and how the materials research community can effectively engage with industry and policymakers.
Peculiarities of Investigating Criminal Offenses Related to Illegal Turnover of Narcotic Drugs, Psychotropic Substances, Their Analogues or Precursors: Criminal Law Aspect
Authors: Korniienko Maksym , Desyatnik Anatolii , Didkivska Galina , Leheza Yevhen , Titarenkо Oleksiy 
Published: January 2024

The article highlights the legal regulation of peculiarities concerning investigation of criminal offenses related to the illegal turnover of narcotic drugs, psychotropic substances, their analogues or precursors.. Main content. It has been established that effectiveness of pre-trial investigation in criminal proceedings on the facts of illegal sale of substances excluded from free circulation using the Internet and other telecommunication technologies is complicated by the need to identify the user under a nickname. Methodology: The methodological basis of the research is presented as comparative-legal and systematic analysis, formal-legal method, interpretation method, hermeneutic method as well as methods of analysis and synthesis. Conclusions. It has been established that in today’s conditions, against the background of the global IT development of society and the active introduction of the latest technologies in all spheres of human life, the forms of sale of narcotic drugs, psychotropic substances, their analogues or precursors are also changing. While using the assets of modern technologies criminals constantly improve their criminal activities, change directions of interaction with the aim of committing offenses. In Ukraine, as well as in the world in general, drug crimes are actively carried out through smartphones via the “Internet” network using messengers and special applications for the distribution of psychoactive substances, narcotic drugs and their analogues.
Plataforma de Monitoreo Cardiovascular Basado en Internet de las Cosas
Authors: Mardini Johan , Ibarra Rosa , Villa Melissa , Arteta Camilo , Pulgar-Emiliani Maria 
Published: January 2024

Introducción: El área de investigación enfocado a la salud ha llevado al desarrollo de plataformas de sistemas de monitoreo cardiovascular teniendo en cuenta la implementación del internet de las cosas como eje central de la innovación tecnológica en ambientes médicos. A su vez las técnicas de aprendizaje automático y lenguaje maquina (ML) han demostrado su importancia en el ámbito de análisis de datos, extrayendo de forma eficaz información para una toma de decisiones efectiva en el ámbito de la medicina de precisión.
Objetivo: Este articulo tiene como objetivo presentar resultados del diseño, prueba y evaluación de un prototipo de sistema de monitoreo de variables cardiovasculares, en donde pueden ser guardadas y mostradas en tiempo real en la nube.
Metodología: Para el desarrollo de esta se utilizaron sensores no invasivos corporales y sistemas embebidos de bajo costo, lo cual permiten ser implementados en ambientes médicos.
Resultados: Se demuestra a gran medida la viabilidad de implementar tecnologías novedosas enfocadas a internet de las cosas (IOT) generando soluciones de bajo costo y consumo energético para generar un sistema de adquisición, monitoreo y alerta en ambientes médicos.
Conclusiones: El prototipo permite a los profesionales de la salud no tener contacto constante con los pacientes que posean este dispositivo instalado en su cuerpo, pero obteniendo muestras medicas en cualquier momento bajo la implementación de esta herramienta.
Delay in final opinion of autopsy requiring Histo-pathological and chemical analysis
Authors: Singh Amandeep , Raju Sandeep , Harish Dasari , Vaishnav Dalip , Kalsi Gagandeep 
Published: January 2024

Examination of viscera by pathologist or chemical examiner is a must in cases where the cause of death is not confirmed/ could not be ascertained during the autopsy. Viscera is handed over to police to be taken to respective laboratories for histopathological examination or chemical analysis or for both. This leads to delay in giving the final opinion regarding the cause of death.: To study the delay in giving the final opinion of a particular case from the day of postmortem examination. Study included autopsy cases done in the year 2015 and 2018. The data was collected from the PMR, histopathological and toxicological examination reports and from the final opinion. Delay/ time taken at different levels was studied and the average delay at each level was calculated. Average delay for final opinion was found to be 561 and 378 days for the year 2015 and 2018, respectively. In one case this time taken was more than 7 years. About 63% of the cases studied are still awaiting final disposal.
Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract
Authors: Ghudhaib Kadhim K. , Khaleel Fayhaa M. 
Published: January 2024

تمتلك المستخلصات النباتية أهمية خاصة تجاه صحة الإنسان والأنشطة الحيوية لمجموعة واسعة من الأمراض. هدفت الدراسة الحالية إلى التحقق من وجود مكونات فعالة في مستخلص أوراق البردقوش ، وتحديد مضادات الأكسدة ، والأنشطة المضادة للبكتيريا والفطريات ، و LD50 ونشاطها المضاد لمرض السكر. تم تحليل المكونات النشطة نوعيا من خلال طرائق اختبار محددة. وتم قياس الأنشطة المضادة للأكسدة ، LD50 ، مضادات البكتريا والفطريات بالطرائق القياسية. وحددت الفعالية المضادة للسكري عن طريق تقييم ارتفاع السكر وفرط شحميات الدم ووظائف الكبد بالطرائق الطيفية. اكدت النتائج على وجود العديد من المكونات الفعالة تتضمن مركبات الفلافونويد والقلويدات والتربينويدات والعفص والصابونين. كما أظهرت نتائج فعالية مضادات الأكسدة أن مستخلص أوراق البردقوش يمتلك نشاطًا مضادًا للأكسدة مشابهًا لحمض الأسكوربيك. وأظهرت نتائج LD50 أن الجرعة المسموح بها هي 12.5 ملغم / مل. أشارت نتائج الفعالية الحيوية إلى أن مستخلص أوراق البردقوش يمتلك فعالية مضادة لمدى واسع من البكتريا والفطريات المرضية ، ولكن لا يوجد تأثير للمستخلص على E. coli و Staphylococcus aureus حتى عند التراكيز العالية. أظهر مستخلص البردقوش فعالية عاليًة مضادًا للسكري عند المعالجته لمدة أسبوعين بـ 4 ملغم من المستخلص يوميا. مع تحسن مستوى الدهون ووظائف الكبد ومستويات هرمون التستوستيرون بعد العلاج في مجموعة مرضى السكري مقارنة مع مجموعة التحكم. يمكن الاستنتاج أن مستخلص أوراق البردقوش يحتوي على فعالية عالية مضادة للأكسدة مع فعالية حيوية عالية ضد البكتريا والفطريات المرضية ونشاط عال مضاد للسكري مع تعزيز كبير للخصوبة ومستوى عالٍ من الجرعات المسموح بها وفقًا لقيمة LD50.
Soft Sensor Development for Real-Time Interface Tracking in Multiple Product Pipelines Based on Knowledge and Data
Authors: Yuan Ziyun , Chen Lei , Zhang Yuhan , Wu Yucheng , Ji Haoyang , Liu Gang 
Published: January 2024

Summary
Petroleum products are usually consecutively transported in the same multiple-product pipeline, and the occurrence of mixed oil happens during the process. Accurately tracking the mixed oil interface is essential for the optimal scheduling of oil transportation. However, complicated operating conditions and unavoidable measurement noise pose challenges to methods for locating the interface. The data-driven modeling method is a potential solution, but it may face limitations due to issues of overfitting, especially when the data set is contaminated with noise. To tackle such problems, in this paper, we propose a knowledge-informed Bayesian-Gaussian mixture regression (KIBGMR) model to enable the real-time tracking of the interface. The KIBGMR employs finite Gaussian distribution to learn the multimode characteristics of input data, including the hydrothermal data, measured density of tail oil, and the velocity of interface transportation and output data including the measured density of tail oil and interface transportation velocity. Subsequently, it utilizes the prior knowledge related to the regression coefficient through the Bayesian treatment. Evaluations demonstrate that the R2 index achieved by the proposed model in predicting the interface arrival time is greater than 0.98, even with the contaminated data set. This research can help operators accurately grasp the location of the mixed oil interface, formulate reasonable valve switch operations for better management of the mixed oil section, and provide a reference for the method of knowledge-data hybrid modeling.
General purpose propofol target-controlled infusion using the Marsh model with adjusted weight input
Authors: Zhong George , Xu Xiabing 
Published: January 2024

Abstract
We report a simple method for adjusting the weight input of the Marsh target-controlled infusion (TCI) model such that the resulting infusion regime closely mimics the behavior of the Eleveld model, thereby making the Marsh model more precise for patients at the extremes of age and body mass index. To assess the performance of our method, we simulated 2,768 subjects with diverse combinations of age, weight, height and sex undergoing a hypothetical four-hour propofol TCI using both the Marsh model with our weight adjustment and the Eleveld model. The weight adjusted Marsh model produced infusion regimes and corresponding effect site concentrations closely mimicking that of the Eleveld model at all time points, with median and maximum absolute performance errors less than 8.1% and 20.3%, respectively, across the entire cohort. Our weight adjustment method is a simple and robust way of improving the precision of the Marsh model in patients at extremes of age and body mass index, until general purpose TCI models for propofol, such as the Eleveld model, become more widely available in commercial infusion pumps.
Integrating Satellite Altimetry and SAR Technology for Manchar Lake Water Monitoring
Authors: Jamali Shahryar , Zaidi Arjumand , Ali Tauqeer 
Published: January 2024

Abstract

A considerable share of global inland water that fulfills human needs and supports the natural ecosystem is stored in lakes. Mismanaging these resources may trigger extreme floods and droughts. This study utilizes multi-mission altimetry and Synthetic Aperture Radar (SAR) data to monitor water levels and volumetric variations of Manchar Lake. Data from three altimetry missions—Sentinel-3, ICESat-2, and Jason-3— were acquired, processed, and validated from in situ measurements. Moreover, surface area variations from Sentinel-1 SAR data contributed to Lake volume computations. ICESat-2 and Sentinel-3 derived water levels exhibited a strong correlation with actual data, supported by good correlation coefficients (0.84 and 0.95), low mean absolute errors (0.24 and 0.10), and good Nash-Sutcliffe Efficiency statistics (0.61 and 0.91). The performance of the Jason-3 dataset was inferior to that of others, indicating a comparatively weaker correlation (R = 0.80). The observed variance may be linked to the pathway's specific location, close to the bank. This proximity introduces a potential risk of pulse data contamination, as the mixing of water and land may influence the return signal. The lake water levels and surface areas presented a moderate correlation (R = 0.67), suggesting some interdependence and providing insights into the Lake's geometry. This correlation guides selecting an appropriate lake volume formula that approximately represents its characteristics. This study highlights the critical role of satellite technology in managing large lakes and reservoirs, particularly in regions with limited ground data and addressing its importance in bridging the critical data gap.
TASP1 promotes the proliferation and metastasis of breast cancer by up-regulating ESR1
Authors: Xiong Fukang , Zhang Xun , Yan Ming , Xiao Lei , Du Pengcheng , Zhang Pengcheng 
Published: January 2024

Abstract
Background
Among females, breast cancer is the leading cause of cancer-related mortality. While the association between TASP1 and the development of various cancers has been reported, uncertainty remains regarding its role in breast cancer.
Objective
The goal of this study was to investigate the impact of TASP1 in breast cancer and its potential mechanism of action.
Methods
The expression of TASP1 in breast cancer tissues and cell lines was conducted through the utilization of RT-qPCR and western blot. Small interfering RNA (si-RNA) was used to silence the expression of TASP1 in breast cancer cell lines. The assessment of cell proliferation and metastasis ability was conducted by CCK-8 assay, colony-formation assay, wound-healing assay and transwell assay. Differential expression genes (DEGs) of TASP1 were downloaded using bioinformatics analysis, KEGG pathway enrichment analysis was performed to ascertain the connection of TASP1 and steroid hormone biosynthesis.
Results
The level of TASP1 expression was significantly elevated in both breast cancer tissues and cell lines. Silence of TASP1 in breast cancer cell lines resulted in the inhibition of cell proliferation and metastasis. KEGG pathway enrichment analysis revealed significant enrichment of steroid hormone biosynthesis. The silence of TASP1 led to a decrease in the expression of ESR1 and PGR, indicating their potential involvement in the regulation of TASP1.
Conclusions
TASP1 demonstrated upregulation in both breast cancer tissues and cell lines. The silence of TASP1 effectively impeded the proliferation and metastasis of breast cancer cells by suppressing ESR1.
On the relationship between heavy precipitations and widespread circulation patterns in Babolrood basin (North of Iran)
Authors: Razmi Robab , Hesami Narges , Rabiee Zahra , Ostad-Ali-Askari Kaveh 
Published: January 2024

Abstract
Value, intensity, and type of precipitation changes in temporal and spatial dimensions. Changes in precipitation cause changes in rivers flows. In this study for investigating the behavior of precipitation and debit of Babolrood basin, the Goran Talar station selected. Singular spectrum analysis (SSA) have been applied to precipitation and debit data collected in the Babolrood basin during the period 1980–2015. Results shown the existence cycles with 2 years return period in debit and precipitation. Days with heavy precipitation were identified in this basin. Then, atmospheric situation at the sea level pressure (SLP) and high level pressure (500hp) at the heavy precipitation days were analyzed. After grouping these days, based on cluster analysis technique, three patterns were determined as the dominant patterns of heavy precipitation in the Babolrood basin. After determining this patterns, it is found that the formation of short waves on top of long waves and their direction towards Iran is the most important cause of heavy precipitation in the Babolrood basin.
Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study
Authors: Zhu Yingqian , Huang Ce , Zheng Liang , Li Qingqing , Ge Jianli , Geng Shasha , Chen Xin , Yuan Huixiao , Li Yang , Jia Wenwen , Sun keping , Li Yan , Ye Tong , Zhao Zhengme , Liu Hailiang , Liu Zhongmin , Jiang Hua 
Published: January 2024

Abstract

Background: Mesenchymal stem cell (MSC) based therapy holds great promise for cell-based therapy in regenerative medicine. In this study, we aimed to evaluate the safety and efficacy of intravenous infusion of human umbilical cord-derived MSCs (HUC-MSCs) in patients with aging frailty.
Methods: In this randomized, double-blind, placebo-controlled trial, participants diagnosed with aging frailty were randomly assigned to receive intravenous administrations of HUC-MSCs or placebo. All of serious adverse events (SAEs) and AEs were monitored to evaluate the safety of treatment during the 6-month follow-up. The primary efficacy endpoint was alteration of physical component scores (PCS) of SF-36 qualities of life at 6 months. The secondary outcomes including physical performance tests and pro-inflammatory cytokines, were also observed and compared at each follow-up visits. All evaluations were performed at 1 week, 1, 2, 3 and 6 months following the first intravenous infusion of HUC-MSCs.
Results: In the MSCs group, significant improvements in PCS of SF-36 were observed from first post-treatment visit and sustained throughout the follow-up period, with greater changes compared to the placebo group (p=0.042). EQ-VAS scores improved significantly at 2 month (p=0.023) and continued until the end of the 6-month visit (p=0.002) in comparison to the placebo group. The timed up and go (TUG) physical performance test revealed significant group difference and showed continual enhancements over 6 months (p＜0.05). MSC transplantation improved the function of four-meter walking test (4MWT) compared with the placebo group with a decrease of 2.05s at 6 months of follow-up (p=0.21). The measurement of grip strength revealed group difference with MSCs group demonstrating better performance, particularly at 6 months (p=0.002). Inflammatory cytokines (TNF-a, IL-17) exhibited declines in MSCs group at 6 months compared to the placebo group (p=0.034 and 0.033, respectively). There was no difference of incidence of AEs between the two groups.
Conclusion: Intravenous transplantation of HUC-MSCs is a safe and effective therapeutic approach on aging frailty. The positive outcomes observed in improving quality of life, physical performance and reducing chronic inflammation, suggest HUC-MSC therapy may be a promising potential treatment option for aging frailty.
Trial Registration: Clinicaltrial.gov; NCT04314011;
Registered 10 December, 2019;
URL: https://clinicaltrials.gov/ct2/show/NCT04314011.
Risk factors for poor outcomes in patients with acute lower leg compartment syndrome: A retrospective study of 103 cases
Authors: Lin Zhe , Hou Zhiyong , Guo Jialiang , Lin Yongsheng , Zhang Yingze 
Published: January 2024

Abstract

Purpose:
The primary aim of this study was to investigate the risk factors associated with the bad outcomes of acute compartment syndrome (ACS) of lower leg. The secondary objective was to determine if delayed fasciotomy is linked to bad outcomes.
Methods:
In a retrospective study approved by the institutional review board, we identified 103 patients with ACS of lower leg. Among these, 44 patients exhibited bad outcome while 59 patients demonstrated a good outcome. Patient-related factors, laboratory values, and treatment-related factors were analyzed using electronic medical records. Univariate statistical and logistic regression analyses were conducted to determine significance.
Results:
Bivariate analyses showed that the mechanism of injury (P = 0.021), open injury (P = 0.001), arterial injury (P<0.001), HB (P < 0.001), WBC (P = 0.008), ALB (P<0.001), CK at presentation (P = 0.015), peak CK (P<0.001), Ca (P = 0.004), dehydrating agent (P = 0.036), and debridement (P = 0.005) were found to be associated with the risk of poor outcomes. Logistic regression analyses revealed that arterial injury [p < 0.001, OR = 66.172, 95% CI (10.536, 415.611)] was an independent risk factor for poor outcomes. However, HB [p = 0.005, OR = 0.934, 95% CI (0.891, 0.979)] was a protective factor against poor outcomes.
Conclusions:
ACS of the lower leg is a serious complication often associated with a poor prognosis. Patients with arterial injury or lower HB have a significantly increased risk of having poor outcomes. Poor outcomes were not found to be associated with the timing of fasciotomy in this study.
Students’ perception and feedback on Bioethics as a new subject in undergraduate Indian medical curriculum : How far can it help?
Authors: Ganguly Barna , Duarte Ivono , DeSouza Russell F , Nunes Rui 
Published: January 2024

Abstract
Background:The National Medical Commission of India introduced Competency Based Curriculum in Medical Education for undergraduate medical students in 2019 with a new module namely Attitude, Ethics and Communication (AETCOM) across the country. This was first of its kind to implement Bioethics as a subject in medical curriculum. It is necessary to take feedback from the students which can serve as a communication and a tool for evaluation of implementation process.
Objectives: This study was aimed to explore the perceptions and feedback of students and align the observation with implementation through inductive reasoning.
Methods: It was a questionnaire based study on the medical students of India who underwent the introduction of AETCOM module for the first time. This was followed by analysis through inductive reasoning on the observed key areas of the feedback data.
Results: There were mixed responses on perception as well as feedbacks. Majority of the students felt the necessity of teaching learning bioethics but not to be taught in closed classroom based teaching. They preferred more of bedside teaching on ethical issues instead of classroom teaching based on theories. A few students did not find interest in the theoretical deliberation of this subject. The identified key areas also could led to the conclusion that there is need of innovative teaching methods of Bioethics through more interactive sessions in small groups encouraging active learning strategy.
Conclusion: The study draws the attention of all stakeholders for revision and efforts for further improvement in teaching and assessment process for setting a standard model in medical education in India.