bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of ceftazidime-avibactam susceptibility in carbapenem resistant Klebsiella pneumoniae and Pseudomonas aeruginosa isolates
Authors: KOCA Özlem , TIĞLI Gül Aydın , ÖZEN Hatice Nevgün , ÇEKİN Yeşim , SEYMAN Derya 
Published: January 2024

Aims: Carbapenem-resistant Gram-negative microorganisms are gradually increasing in hospitalized patients in intensive care units and causes increased morbidity, mortality, and cost. This study aims to investigate the susceptibility of ceftazidime-avibactam (caz-avi), which has recently started to be used for the treatment of infections caused by carbapenem-resistant (CR) Gram-negative bacteria isolated from various samples received from the intensive care unit (ICU) of our hospital.
Methods: Carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) strains isolated from various clinical specimens that were sent to our laboratory between January 1st, 2021, and October 30th, 2022, were retrospectively evaluated in the study. The culture and antibiogram results of the samples were received over the laboratory information system (LIS) and evaluated using statistical analyses. Ceftazidime-avibactam susceptibility was studied using the disc diffusion method.
Results: Ceftazidime-avibactam antibiotic susceptibility test results of 352 (69.4%) CRKP and 155 (30.6%) CRPA strains isolated from various clinical samples from the ICU of our hospital were analyzed. Of the CRKP strains, 313 (88.9%) were found to be susceptible and 39 (11.1%) were found to be resistant to ceftazidime-avibactam. Of the CRPA strains, 131 (84.5%) were found to be susceptible and 24 (15.5%) were found to be resistant.
Conclusion: Determining the regional susceptibility of carbapenem-resistant strains isolated in our hospital to a new antimicrobial combination such as caz-avi will allow a better understanding of the spread of resistance.
The effects of smartphone addiction on sleep quality and obesity level in obese men
Authors: AKINCI Tuba , OKUMUS Nazik , ALTAY Murat 
Published: January 2024

Aims: To investigate the effects of smartphone addiction on sleep quality and body mass index (BMI) values in obese men.
Methods: During the study period, 90 men aged 18 to 45 years who were monitored for obesity, presented to the hospital, and agreed to participate in the study were recruited. The study statistically evaluated sleep quality and factors affecting it using patient demographic characteristics, the Pittsburgh Sleep Quality Index (PSQI), the Smart Phone Addiction Scale (SPAS), and the Hospital Anxiety-Depression Scale (HADS).
Results: Patients were divided into two groups according to PSQI score: PSQI ≥5 n:51 (56.7%) and PSQI
Predictive factors for acute pancreatic and peripancreatic fluid development in patients with acute pancreatitis
Authors: KARAAHMETOĞLU Selma , COŞKUN Mehmet Veysel , İNAN Osman , KURTİPEK Ali Can 
Published: January 2024

Aims: Acute fluid collections after acute pancreatitis carries risk of serious complications as infected pseudocyst and Wall off Necrose development. Hence, it is important to predict the development of acute fluid collections for treatment and management of acute pancreatitis. In this study, it is aimed to investigate predictive factors for development of acute fluid collections in patients with acute pancreatitis.
Methods: Total of 438 patients diagnosed with acute pancreatitis were screened. According to the Revised Atlanta Classification fluid development after acute pancreatitis was determined and the relationship between fluid development and the hematological/biochemical parameters of the patients at the time of admission was investigated. The best cut-off point of laboratory measurements for fluid development was determined by ROC analysis and the factors that may be most decisive in distinguishing between the patients with and without fluid development were determined by multivariate forward stepwise logistic regression analysis.
Results: It is found that developing acute fluid collections after acute pancreatitis was higher in patients with younger age and male gender. Also the risk of developing acute fluid collections after acute pancreatitis was found to be 6.2 times higher in patients with CRP/Albumin ratio greater than 1.09; 2.5 times higher in patients with ALP below 199.5 U/L; 1.9 times higher in patients with WBC greater than 11,6 ×10⁹/L and 1.5 times higher in patients with PLR above 197.1. Also the risk of developing acute necrotic collections after acute pancreatitis was 3 times higher in patients with serum calcium level below 8,6 mg/dl.
Conclusion: It has been determined that, presence of high CRP/albumin ratio, high NLR and low serum ALP level can be used as an indicator in predicting acute pancreatic and peripancreatic fluid development.
Comparison of procalcitonin, C-reactive protein, white blood cell counts and hemogram subparameters in community acquired pneumonia patients
Authors: BARDAKÇI Mustafa İlteriş , AYHAN ALBAYRAK Gülhan 
Published: January 2024

Aims: Pneumonia is a clinically and radiologically detected inflammation of the lungs. Most of the pneumonia patients are community-acquired pneumonia cases. Hemogram and C-reactive protein (CRP) are commonly used to support diagnosis and follow-up of treatment. Procalcitonin is less accessible and expensive. And the use of hemogram subparameters is not very common. The aim of this study was to research the relationship between procalcitonin, CRP, White Blood Cell count (WBC) and hemogram subparameters in patients with CAP and the efficacy of new hematologic rates in differential diagnosis.
Methods: Patients who were diagnosed with community acquired pneumonia by applying to the chest diseases outpatient clinic of our hospital were retrospectively analyzed. 67 patients who were clinically and radiologically diagnosed without noticing male or female were included in our study. Anamnesis data and co-morbidities of the cases were questioned. Procalcitonin, CRP and hemogram (platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) were calculated and WBC value was examined) were recorded. The obtained data were evaluated statistically and compared in terms of variables.
Results: The mean age of our patients was 57 (18-71) years; there were 41 (61.19%) female and 26 (38.81%) male patients. 36 (53.73%) of our patients had chronic diseases; 21 (31.34%) had heart disease, 23 (34.32%) had diabetes, and 6 (8.95%) had kidney failure. Patients; 48 (71.64%) procalcitonin, 56 (83.58%) CRP, 38 (56.71%) WBC, 52 (77.61%) NLR, 34 (50.74%) PLR and 38 (56.71%) MLR values were high. Procalcitonin, CRP and NLR values were significantly higher than other subparameters. The CRP and NLR values of patients with an additional chronic disease were higher than patients without co-morbidities. In the correlation analyses, there was a strong correlation between procalcitonin, CRP and NRL, but the correlation between the others was not significant. (p
Prognostic evaluation of newborns with neonatal hyperbilirubinemia
Authors: ÇAY Özlem Özcanlı , KEMER Özlem 
Published: January 2024

Aims: We aimed to investigate the effect of phototherapy treatment by showing that it increases systemic inflammation and changes in NLR (neutrophil count/lymphocyte count), PLO (platelet count/lymphocyte count), systemic Inflammation Index (platelet count × neutrophil count/lymphocyte count ratio) in peripheral blood.
Methods: It was conducted at Balıkesir University Health Practice and Research Hospital between April 2023 and August 2023. 60 babies with a gestational age of ≥36 weeks and a birth weight of ≥2500 g were included in the study.
Results: A statistically significant difference was detected between WBC, lymphocyte count, monocyte count, neutrophil count, lymphocyte/monocyte, systemic inflammatory index before and after phototherapy (p
Clinical and radiological outcomes of gunshot-induced femur fractures: a comparative study of monolateral external fixators and hybrid advanced ilizarov method
Authors: SEVER Cem , KARIKSIZ Mesut 
Published: January 2024

Aims: Clinical and radiological outcomes, complication rates, and 10-year follow-up results of comminuted femoral open fractures resulting from firearm injuries were evaluated by comparing the Hybrid Advanced Ilizarov method (HAIM) and monolateral external fixator (MEF) of the limb reconstruction system (LRS) for treatment.
Methods: Nineteen patients (18 males, 1 female) treated with HAIM and 14 male patients treated with MEF-LRS for femoral comminuted open fractures due to firearm injuries were retrospectively analyzed. Complication rates, pin tract and deep infection rates, time to union, and the need for secondary surgeries were assessed. The Tegner activity score and Short Form-36 (SF-36) were used for comparative evaluation of functional and radiological outcomes and comfort levels with the fixator.
Results: There were no significant differences between the groups in terms of age, gender, follow-up duration, time to union, union rate, delayed union, or deep infection. No infections were detected in either group that required a change in the fixation method. There were no significant differences in radiological and functional outcomes between the groups. Significant differences were observed in terms of pin tract infections between the groups. The comfort level of MEF-LRS patients was significantly higher than that of HAIM patients.
Conclusion: In the treatment of femoral fractures due to firearm injuries in early and long-term follow-ups, similar complication rates and functional outcomes were achieved for both MEF-LRS and HAIM methods. When considering external fixator preference, MEF-LRS is a better alternative, with a lower rate of pin tract infections and higher patient comfort level.
Analisis Drug Related Problems Kategori Overdose, Underdose, dan Drug Interaction Pasien Tuberkulosis RS dr. Soepraoen Malang
Authors: Sugihantono Amelia Nadya , Ardianto Nanang , Salmasfattah Novyananda , Virgiansyah Reyvan Admaja Bagas 
Published: January 2024

Latar belakang: Di Indonesia banyak kejadian yang tidak menyenangkan yang berkaitan dengan pengobatan yang dikenal sebagai masalah terkait obat yang dapat menggangu hasil klinis kesehatan pasien disebut sebagai DRPs. Tuberkulosis merupakan penyakit kronik akibat bakteri Mycrobacterium Tuberculosis. Dalam terapi, pasien tuberkulosis perlu banyak obat, yang meningkatkan resiko DRPs. Tujuan: Menganalisis kejadian DRPs kategori overdose, underdose, dan drug interaction pasien tuberkulosis. Metode: Jenis penelitian ini adalah kuantitatif non eksperimental dengan metode pendekatan deskriptif dengan pengambilan data secara retrospektif yaitu data rekam medis pasien tuberkulosis periode Januari 2022 – Maret 2023 selama rawat inap RS dr.Soepraoen Malang. Metode pengambilan sampel dalam penelitian ini adalah total sampling. Populasi sama dengan sampel melibatkan 40 pasien. Analisis data masing-masing kategori berdasarkan aplikasi Drug.com dan Permenkes no.67 tahun 2016 dalam bentuk distribusi presentase. Hasil: Analisis DRPs berdasarkan karakteristik pasien Tuberkulosis RS dr. Soepraoen Malang didominasi laki-laki sebesar 67,5% dan yang paling banyak menderita tuberkulosis adalah usia 46-55 tahun. Simpulan: Masalah terkait obat pada pasien tuberkulosis yang menjalani perawatan di RS dr. Soepraoen Malang ialah 46 kasus. Kasus DRPs termasuk 1 kasus overdose (2,2%), 4 kasus underdose (8,7%), dan 41 kasus drug interaction (89,1%).
Hubungan Tingkat Kontrol Asma dengan Kualitas Hidup Pasien Asma di Poli Paru RS. Lavalette Malang
Authors: Nanang Ardianto , Aggilya Umi Rikha , Widara Ratih Tyas , Arianti Sindi Wahyu 
Published: January 2024

Latar belakang: Asma merupakan penyakit heterogen dengan gejala peradangan pada saluran pernapasan, secara terus menerus serta gejala batuk yang bervariasi, sesak dada, sesak nafas, dan mengi. Tingkat kontrol asma mengacu pada seberapa baik karakteristik asma dapat diamati pada pasien penderita asma dan seberapa baik gejalanya berkurang atau tidak muncul setelah pengobatan diberikan. Kualitas hidup adalah tingkat kemampuan, keterbatasan, gejala, dan karakteristik psikososial seseorang untuk berfungsi dengan baik dan merasa puas dengan peran mereka dalam masyarakat. Tujuan: Mengetahui korelasi tingkat kontrol asma dengan kualitas hidup pasien di poli paru RS Lavalette Malang. Metode: Penelitian kuantitatif non eksperimental ini menggunakan pendekatan korelatif. Subjek pada penelitian 50 responden Penelitian ini mengguakan teknik sampling accidental sampling. Alat penelitian yang digunakan adalah kuesioner Asthma control test dan Mini-Asthma Quality of Life Questionnaire. Penelitian ini menggunakan analisis bivariate SPSS, Rank Spearman. Hasil: Menunjukan bahwa18 responden (36%) asma tidak terkontrol, 27 responden (54%) memiliki kontrol sebagian, 5 responden (10%) asma terkontrol penuh dan responden dengan kualitas hidup baik sebanyak 37 (74%), kualitas hidup kurang baik 13 responden (26%). Terdapat korelasi antara tingkat kontrol asma dan kualitas hidup pasien asma di Poli Paru RS Lavalette Malang, dengan nilai p = 0.026 (< 0.05). Simpulan: terdapat korelasi tingkat kontrol asma dengan kualitas hidup pasien asma
Path Analysis to Assess Diversity of Occupational Opportunities Within Walking Distance and Community Health
Authors: Melton Amber , Medina Madison , Holloway Jade , Maitra Kinsuk 
Published: January 2024

Abstract
Importance: Built environment structures affect a population’s occupational participation and health outcomes.
Objective: To examine how occupational opportunities available within walking distance are related to a community’s overall health.
Design: Secondary data analysis.
Setting: Community.
Participants: Community-dwelling adults.
Outcomes and Measures: Data from the AARP Livability Index and Walk Score® for 78 zip codes were used for path analysis and multiple regression analysis to investigate the relationship between various community factors and the health of the community.
Results: Path analysis for 78 zip codes revealed that the primary determinants of health score were destination diversity and social walk score. Multiple regression analysis revealed that destination diversity (β &lt; .001) and exercise opportunity (β &lt; .001) were significant factors for health score. Multiple regression analysis revealed that destination diversity (β &lt; .001) was a significant factor for social score.
Conclusions and Relevance: The results suggest that increased diversity of destinations in a community and opportunities available for social participation within walking distance are associated with better health of residents in the community.
Plain-Language Summary: This study highlights how the built environment and opportunities for social participation are associated with a community’s overall health. This study found that participation in a variety of group activities contributes to community members’ well-being. Understanding how the built environment is related to health outcomes may better equip occupational therapy practitioners to improve the health of an individual, group, or population.
Evaluation of the effect of a dietary supplementation with a red yeast rice and fish oil-containing nutraceutical on lipid pattern, high sensitivity C-reactive protein, and endothelial function in moderately hypercholesterolaemic subjects: a double-blind, placebo-controlled, randomized clinical trial
Authors: Fogacci Federica , Giovannini Marina , Di Micoli Valentina , Grandi Elisa , Veronesi Maddalena , Borghi Claudio , Cicero Arrigo F.G. 
Published: January 2024

IntroductionRed yeast rice and omega-3 polyunsaturated fatty acids (PUFAs) are dietary supplements with well-known lipid-lowering, anti-inflammatory, and vascular health improving effects. However, they have rarely been tested in combination. The aim of our study was to test the short-term effect of a combined nutraceutical including red yeast rice and PUFAs on plasma lipids, jigh-sensitive C-reactive protein (hsCRP), and endothelial function in healthy subjects.Material and methodsWe carried out a double-blind, randomized, placebo-controlled clinical trial with parallel groups testing the effect of 8 weeks of supplementation with softgels containing red yeast rice (2.8 mg monacolins) and PUFAs (588 mg of fish oil, standardized in PUFAs: 350 EPA, 45 mg DHA) versus placebo. A full lipid panel, hsCRP, and endothelial reactivity were measured at the baseline and after 8 weeks of treatment.ResultsThe tested combined nutraceutical was very well tolerated, and after 8 weeks of supplementation it was associated with a 17.3 ±3.4% reduction of lipid-density lipoprotein-cholesterol (LDL-C), a 12.1 ±2.2% reduction of total cholesterol (TC), a 22.3 ±4.3% reduction of apoB, and a –14.9 ±1.8% reduction of hsCRP, as well as a significant improvement of pulse volume change by 5.0 ±0.9%.ConclusionsThe tested combined dietary supplement containing red yeast rice and PUFAs was very well tolerated and significantly improved LDL-C, TC, apoB, hsCRP and endothelial function in healthy subjects with suboptimal LDL-cholesterolaemia.
Diagnostic performance of cone-beam computed tomography
for apical periodontitis: a systematic review and meta-analysis
Authors: Abesi Farida , Golikani Ali 
Published: January 2024

IntroductionWe aimed to conduct a systematic review and meta-analysis of studies examining the performance of cone-beam computed tomography (CBCT) imaging in apical periodontitis (AP) prediction. This was done to address the contradictory results reported in the existing literature on this topic.Material and methodsWe searched the Embase, PubMed, Cochrane library, and Scopus databases for literature published from inception to 30 June 2023 without language restriction using appropriate keywords. We included studies that reported the diagnostic accuracy values of CBCT in AP detection among humans by comparing AP diagnosis with a control group without lesions. We pooled the diagnostic accuracy values using a random effects model and presented the estimates as percentage and 95% confidence interval (CI). The heterogeneity between the surveys was explored by I2 statistic.ResultsOut of 301 citations initially identified, a total of 8 eligible studies were finally included. According to the analyses, the overall pooled sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) estimated for CBCT were 94.6% (95% CI: 90.2-97.1; I2 = 55.9%, p = 0.026), 91.2% (95% CI: 81.7-96.0; I2 = 81.6%, p < 0.001), 93.0% (95% CI: 87.4-96.2; I2 = 56.5%, p = 0.024), and 92.3% (95% CI: 82.3-96.8; I2 = 86.4%, p < 0.001), respectively. The overall pooled sensitivity, specificity, PPV, and NPV of digital radiography were 61.0% (95% CI: 38.3-79.8; I2 = 94.4%, p < 0.001), 97.3% (95% CI: 85.6-99.5; I2 = 86.7%, p < 0.001), 98.3% (95% CI: 92.0-99.6; I2 = 74.4%, p = 0.002), and 41.6% (95% CI: 28.0-56.6; I2 = 89.5%, p < 0.001), respectively.ConclusionsCBCT imaging has excellent diagnostic accuracy in AP prediction. Also, CBCT has better discriminant test performance for AP than digital radiography.
Bycatch Estimates of Dugongs and Dolphins: Results from an Interview Survey of Fishermen in Brunei Bay, Malaysia
Authors: Rahim Nurul Hidayah Abdul , Raman Azzakirat Abdul , Muda Azmi Marzuki , Jaaman* Saifullah Arifin , Zhang Xuelei 
Published: January 2024

Bycatch refers to the unintentional capture of non-targeted animals during fishing activities. Worldwide, bycatch poses a significant threat to marine mammal species. In the Southeast Asian region, information on bycatch is particularly scarce, and there is little indication that the issue is adequately addressed anywhere in the region. To address this knowledge gap, we conducted face-to-face interview surveys across fishing communities in the Malaysian side of the Brunei Bay. We collected two datasets of marine mammal bycatch incidences from two different groups of fishermen (N=90 of 356 reported dugong data, 0.3%, and N=62 of 146 reported dolphin data, 0.4%), to estimate the levels of mortalities of the marine mammals. More than four fifths (82.1%) of respondents reported that they have accidentally captured at least one marine mammal (25.0% dugong and 42.5% dolphin) throughout their lifetime as a fisherman, with the highest frequency of occurrence being reported by fishers using gillnets (53.5% and 38.7%, respectively). Our interview results suggest an annual bycatch of 0.22 (95% CI = 0.13 to 0.32) for dugongs and 0.65 (95% CI = 0.40 to 0.88) for dolphins in the Malaysian Brunei Bay. Findings from this study provides important data to guide fisheries resource managers in providing protection and conservation efforts the endangered marine mammal populations.
Innovation Performance Analysis of G20 Countries: A Novel Integrated LOPCOW-MAIRCA MCDM Approach Including the COVID-19 Period
Authors: ÖZTAŞ Tayfun , ÖZTAŞ Gülin Zeynep 
Published: January 2024

Purpose: This study aims to examine the innovation performance of G20 countries in 2018-2022 with multi criteria decision making methods. When the 5-year performance was analyzed, it was also revealed whether the COVID-19 outbreak has an impact on the innovation performance of the countries.
Methodology: An integrated LOPCOW (Logarithmic Percentage Change-driven Objective Weighting) - MAIRCA (Multi Attribute Ideal-Real Comparative Analysis) method was applied in the study. First, the indicators representing innovation performance (institutions, human capital, and research, infrastructure, market sophistication, business sophistication, knowledge and technology outputs, creative outputs) was objectively weighted by the LOPCOW method. Then, the innovation performance of G20 countries was calculated with the MAIRCA method. Finally, a comparative analysis was also presented to support the findings.
Findings: As a result of the innovation performance analysis using multi criteria decision making methods, human capital, and research were found to be the most important indicators, and the United States was found to be the country with the best innovation performance. In the sensitivity and comparative analysis, it was concluded that the integrated LOPCOW-MAIRCA method provides robust outputs.
Originality: This study makes original contributions by analyzing the impact of the COVID-19 pandemic on the innovation performance of countries considering the 2018-2022 period and the integrated multi criteria decision making methods it uses that have not yet been applied in the literature.
The Impact of R&D Expenditures on Economic Growth in Türkiye: New Evidence from Machine Learning Method
Authors: ACAR Yasin , KESİCİ İbrahim 
Published: January 2024

Purpose: This study analyzes the impacts of R&D expenditures on economic growth in Türkiye.
Methodology: In this study, we explore the impact of R&D expenditure on economic growth in Türkiye. Annual time series from 1990 to 2021 are considered for this research examination based on the data availability. R&D expenditure, Gross Domestic Product (GDP) per capita, gross fixed capital formation, labor force, and tertiary ratio variables are used for the analysis and obtained from the World Bank. Based on machine learning, analyses were conducted using the Kernel Regularized Least Square method.
Findings: The empirical analysis using KRLS shows that higher spending on research and development leads to a significant boost in economic growth. Furthermore, labor force participation, school enrolment (tertiary) ratio, and gross fixed capital formation are all significantly and positively associated with economic growth in Türkiye.
Originality: The contribution of the paper is twofold: (1) it provides new scientific evidence based on the machine learning econometric method, the Kernel Regularized Least Square (KRLS); (2) many papers in the literature have only examined the relationship between R&D expenditures and economic growth, without controlling for other variables. We have used possible control variables such as labor force participation rate, school enrolment (tertiary) ratio, and gross fixed capital formation, which are also linked to economic growth models.