bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased prevalence of erythema multiforme in patients with COVID-19 infection or vaccination
Authors: Saleh Wafaa , Alharbi Hamad , Cha Seunghee 
Published: February 2024

AbstractSeveral reports stated that erythema multiforme (EM) was associated with COVID-19 with detrimental outcomes in patients. However, since most of these are case reports, it is challenging to quantitively assess their associations. Therefore, our study aims to determine the prevalence of EM in the context of COVID-19. The study was designed as a retrospective cross-sectional hospital-based study of registered patients at the University of Florida Health Hospital. The ICD-10 codes for EM, COVID-19 infection, and COVID-19 vaccines were searched in the database. The odds ratio was calculated to assess the risk of EM after COVID-19 infection or vaccination. Our study included 43,547 patients with a history of COVID-19 infection, of whom 92 developed EM. Patients with COVID-19 infection were 6.68 times more likely to have EM than those without COVID-19 (P < 0.0001). Similarly, the risk of developing EM after COVID-19 vaccination was 2.7, significantly higher than the general population (P < 0.0001). The prevalence of EM following COVID-19 infection or vaccination significantly differs from the general population, highlighting the importance of monitoring patients for EM after COVID-19 infection and/or vaccination. It is imperative to disseminate awareness to clinicians and patients regarding the impact of COVID-19 on EM.
Atypical brain lateralization for speech processing at the sublexical level in autistic children revealed by fNIRS
Authors: Lai Baojun , Yi Aiwen , Zhang Fen , Wang Suiping , Xin Jing , Li Suping , Yu Luodi 
Published: February 2024

AbstractAutistic children often exhibit atypical brain lateralization of language processing, but it is unclear what aspects of language contribute to this phenomenon. This study employed functional near-infrared spectroscopy to measure hemispheric lateralization by estimating hemodynamic responses associated with processing linguistic and non-linguistic auditory stimuli. The study involved a group of autistic children (N = 20, mean age = 5.8 years) and a comparison group of nonautistic peers (N = 20, mean age = 6.5 years). The children were presented with stimuli with systematically decreasing linguistic relevance: naturalistic native speech, meaningless native speech with scrambled word order, nonnative speech, and music. The results revealed that both groups showed left lateralization in the temporal lobe when listening to naturalistic native speech. However, the distinction emerged between autism and nonautistic in terms of processing the linguistic hierarchy. Specifically, the nonautistic comparison group demonstrated a systematic reduction in left lateralization as linguistic relevance decreased. In contrast, the autism group displayed no such pattern and showed no lateralization when listening to scrambled native speech accompanied by enhanced response in the right hemisphere. These results provide evidence of atypical neural specialization for spoken language in preschool- and school-age autistic children and shed new light on the underlying linguistic correlates contributing to such atypicality at the sublexical level.
Influences of lumbo-sacral transitional vertebrae for anterior lumbar interbody fusion
Authors: Becker Luis , Mihalache Tim Victor , Schmidt Hendrik , Putzier Michael , Pumberger Matthias , Schömig Friederike 
Published: February 2024

AbstractLumbo-sacral transitional vertebrae (LSTV) are frequent congenital variances of the spine and are associated with increased spinal degeneration. Nevertheless, there is a lack of data whether bony alterations associated with LSTV result in reduced segmental restoration of lordosis when performing ALIF. 58 patients with monosegmental stand-alone ALIF in the spinal segment between the 24th and 25th vertebra (L5/S1)/(L5/L6) where included. Of these, 17 patients had LSTV and were matched to a control population by age and sex. Pelvic incidence, pelvic tilt, sagittal vertical axis, lumbar lordosis, segmental lordosis, disc height and depth were compared. LSTV-patients had a significantly reduced segmental lordosis L4/5 (p = 0.028) and L5/S1/(L5/L6) (p = 0.041) preoperatively. ALIF resulted in a significant increase in segmental lordosis L5/S1 (p < 0.001). Postoperatively, the preoperatively reduced segmental lordosis was no longer significantly different in segments L4/5 (p = 0.349) and L5/S1/(L5/6) (p = 0.576). ALIF is associated with a significant increase in segmental lordosis in the treated segment even in patients with LSTV. Therefore, ALIF is a sufficient intervention for restoring the segmental lordosis in these patients as well.
Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms
Authors: Holl Kristin , Chatain Nicolas , Krapp Susanne , Baumeister Julian , Maié Tiago , Schmitz Sarah , Scheufen Anja , Brock Nathalie , Koschmieder Steffen , Moreno-Andrés Daniel 
Published: February 2024

AbstractMyeloproliferative neoplasms (MPNs) encompass a diverse group of hematologic disorders driven by mutations in JAK2, CALR, or MPL. The prevailing working model explaining how these driver mutations induce different disease phenotypes is based on the decisive influence of the cellular microenvironment and the acquisition of additional mutations. Here, we report increased levels of chromatin segregation errors in hematopoietic cells stably expressing CALRdel52 or JAK2V617F mutations. Our investigations employing murine 32DMPL and human erythroleukemic TF-1MPL cells demonstrate a link between CALRdel52 or JAK2V617F expression and a compromised spindle assembly checkpoint (SAC), a phenomenon contributing to error-prone mitosis. This defective SAC is associated with imbalances in the recruitment of SAC factors to mitotic kinetochores upon CALRdel52 or JAK2V617F expression. We show that JAK2 mutant CD34 + MPN patient-derived cells exhibit reduced expression of the master mitotic regulators PLK1, aurora kinase B, and PP2A catalytic subunit. Furthermore, the expression profile of mitotic regulators in CD34 + patient-derived cells allows to faithfully distinguish patients from healthy controls, as well as to differentiate primary and secondary myelofibrosis from essential thrombocythemia and polycythemia vera. Altogether, our data suggest alterations in mitotic regulation as a potential driver in the pathogenesis in MPN.
Exploring the causal relationship between B lymphocytes and Parkinson’s disease: a bidirectional, two-sample Mendelian randomization study
Authors: Song Jia , Qin Yidan , Wang Lin , Quan Wei , Xu Jing , Li Jia , Chen Jiajun 
Published: February 2024

AbstractParkinson’s disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients and society. B lymphocytes, a group of immune cells associated with humoral immunity, have been shown to be involved in the pathogenesis of PD. However, the causal relationship and potential pathogenic effects of B cell in PD remain unclear. Based on the three core hypotheses of the Mendelian randomization (MR) study, we explored causal associations between 190 B-cell immunological traits and 482,730 European individuals (Ncase = 33,674, Ncontrol = 449,056) from genome wide association studies by means of the two-sample bidirectional MR method. The inverse‑variance weighted method was selected as the main approach when conducting MR analysis. Finally, the results were verified by the heterogeneity and horizontal pleiotropy analyses. Five B-cell immunological phenotypes were nominally associated with PD at the significance threshold of P < 0.05. Concretely, IgD + CD38− B cell %lymphocyte (OR 1.052, 95% CI 1.001–1.106, P = 0.046), CD20 on IgD− CD24− B cell (OR 1.060, 95% CI 1.005–1.117, P = 0.032), CD38 on IgD+ CD24− B cell (OR 1.113, 95% CI 1.028–1.206, P = 0.009), and BAFF-R on CD20− B cell (OR 1.093, 95% CI 1.010–1.184, P = 0.027) were identified as risk factors for PD. Instead, CD38 on Plasma Blast-Plasma Cell (OR 0.894, 95% CI 0.802–0.996, P = 0.043) was proved to be protective. However, there is no statistically significant correlation between B cell and PD after Bonferroni correction. The results of reverse MR were negative, avoiding the reverse causal effects. Eventually, the association results were identified as stable across several sensitivity analyses. Briefly, our study might demonstrate the key factor of B cells in PD. Further studies are warranted to clarify the associations for early identification and immunotherapeutic development in PD patients.
The significance of glial cell line-derived neurotrophic factor analysis in Progressive Supranuclear Palsy
Authors: Alster Piotr , Otto-Ślusarczyk Dagmara , Szlufik Stanisław , Duszyńska-Wąs Karolina , Drzewińska Agnieszka , Wiercińska-Drapało Alicja , Struga Marta , Kutyłowski Michał , Friedman Andrzej , Madetko-Alster Natalia 
Published: February 2024

AbstractProgressive Supranuclear Palsy (PSP) is an atypical parkinsonism. Major subtypes of the disease: PSP-Richardson’s Syndrome (PSP-RS) and PSP Parkinsonism Predominant (PSP-P) vary in clinical features, the pathomechanism remains unexplored. The aim of this work is to analyze the relevance of glial cell line-derived neurotrophic factor (GDNF) evaluation in the serum and cerebrospinal fluid (CSF) in PSP subtypes and to verify its significance as a possible factor in the in vivo examination. Authors assessed the concentration of GDNF in the serum and CSF of 12 patients with PSP-RS, 12 with PSP-P and 12 controls. Additionally authors evaluated patients using Unified Parkinson’s Disease Rating Scale—III part (UPDRS-III), Frontal Assessment Battery (FAB) and Magnetic Resonance Imaging (MRI). The evaluation revealed significantly increased concentrations of GDNF in the CSF among PSP-RS patients and substantially increased concentrations of GDNF in the serum in PSP-P. Though the GDNF concentrations differentiated PSP subtypes, no correlations between with clinical factors were observed however certain correlations with atrophic changes in MRI were detected. GDNF is a factor which may impact the pathogenesis of PSP. Possible implementation of GDNF as a therapeutic factor could be a perspective in the search for therapy in this currently incurable disease.
Systematic review and meta-analysis of serum total testosterone and luteinizing hormone variations across hospitalized Covid-19 patients
Authors: Salciccia Stefano , Moriconi Martina , Asero Vincenzo , Canale Vittorio , Eisenberg Michael L. , Glover Frank , Belladelli Federico , Seranio Nicolas , Basran Satvir , De Berardinis Ettore , Di Pierro Giovanni , Ricciuti Gian Piero , Chung Benjamin I. , Sciarra Alessandro , Del Giudice Francesco 
Published: February 2024

AbstractA growing body of evidence suggests the role of male hypogonadism as a possible harbinger for poor clinical outcomes across hospitalized Covid-19 patients. Accordingly, we sought to investigate the impact of dysregulated hypothalamic-pituitary–gonadal axis on the severity of the clinical manifestations for hospitalized Covid-19 patients matched with healthy controls through a systematic review and meta-analysis. Databases were searched from inception to March 2022. A standardized mean difference (SMD) meta-analysis focused on hospitalized Covid-19 patients and healthy controls was developed for studies who reported total testosterone (TT) and luteinizing hormone (LH) levels at hospital admission. Overall, n = 18 series with n = 1575 patients between 2020 and 2022 were reviewed. A significant decrease in SMD of TT levels in Covid-19 patients compared to paired controls was observed (− 3.25 nmol/L, 95%CI − 0.57 and − 5.93). This reduction was even more consistent when matching severe Covid-19 patients with controls (− 5.04 nmol/L, 95%CI − 1.26 and − 8.82) but similar for Covid-19 survivors and non-survivors (− 3.04 nmol/L, 95%CI − 2.04 and − 4.05). No significant variation was observed for serum LH levels across studies. Patient related comorbidities, year of the pandemic, and total lymphocyte count were associated with the observed estimates. TT levels may be a useful serum marker of poor outcomes among Covid-19 patients. These findings may support the development of ad-hoc clinical trials in the Covid-19 risk-group classification and subsequent disease monitoring. The interplay between TT and immune response should be evaluated in future researches.
Swift Prosodic Modulation of Lexical Access: Brain Potentials From Three North Germanic Language Varieties
Authors: Hjortdal Anna , Frid Johan , Novén Mikael , Roll Mikael 
Published: February 2024

Purpose:
According to most models of spoken word recognition, listeners probabilistically activate a set of lexical candidates, which is incrementally updated as the speech signal unfolds. Speech carries segmental (speech sound) as well as suprasegmental (prosodic) information. The role of the latter in spoken word recognition is less clear. We investigated how suprasegments (tone and voice quality) in three North Germanic language varieties affected lexical access by scrutinizing temporally fine-grained neurophysiological effects of lexical uncertainty and information gain.

Method:
Three event-related potential (ERP) studies were reanalyzed. In all varieties investigated, suprasegments are associated with specific word endings. Swedish has two lexical “word accents” realized as pitch falls with different timings across dialects. In Danish, the distinction is in voice quality. We combined pronunciation lexica and frequency lists to calculate estimates of lexical uncertainty about an unfolding word and information gain upon hearing a suprasegmental cue and the segment upon which it manifests. We used single-trial mixed-effects regression models run every 4 ms.

Results:
Only lexical uncertainty showed solid results: a frontal effect at 150–400 ms after suprasegmental cue onset and a later posterior effect after 200 ms. While a model including only segmental information mostly performed better, it was outperformed by the suprasegmental model at 200–330 ms at frontal sites.

Conclusions:
The study points to suprasegmental cues contributing to lexical access over and beyond segments after around 200 ms in the North Germanic varieties investigated. Furthermore, the findings indicate that a previously reported “pre-activation negativity” predominantly reflects forward-looking processing.

Supplemental Material:

https://doi.org/10.23641/asha.25016486
The Utah Gender Presentation Scale for Communication: Development and Validation of a Measure of Voice-Related Gender Incongruence
Authors: Myers Brett R. , Pierce Jenny L. , Mathy Pamela 
Published: February 2024

Purpose:
The aim of the present study was to develop and validate a patient-reported outcome measure for gender incongruence specific to voice and communication parameters, including pitch, intonation, resonance, loudness, speech smoothness, speech clarity, word choice, facial expression, gesture, and posture.

Method:

The Utah Gender Presentation Scale for Communication (U-GPS) includes 10 items, each on a 10-point scale from masculine to feminine. Items were selected based on literature review and patient focus groups. During test administration, respondents provide their current rating and goal rating for each item. The difference between these scores is used to calculate an overall incongruence score. Prospective data from transgender and gender-diverse (
n
= 155) and cisgender (
n
= 69) individuals were then used for a multiparametric psychometric evaluation of the measure.

Results:

Findings demonstrate excellent levels of internal consistency (Cronbach's alpha for current scores: α = .943; Cronbach's alpha for goal scores: α = .970), test–retest reliability (intraclass correlation coefficient = .905), longitudinal validity (improvement in therapy for trans women:
F
= 293.0,
p
< .001; nonbinary folx:
F
= 80.9,
p
< .001), concurrent validity (correlation with the Trans Woman Voice Questionnaire:
r
= .51,
p
< .001), and known-group expectations (differences among five gender groups:
F
= 82.7,
p
< .001).

Conclusion:
The U-GPS is a meaningful measure of voice-related gender incongruence, which is clinically relevant for assessing goals in gender-affirming voice and communication therapy for individuals across the gender spectrum.
The Impact of Morphological Intervention on Literacy Knowledge and Reading Motivation: A Cluster-Randomized Comparison Trial in Diverse Socioeconomic Status Kindergartens
Authors: Vaknin-Nusbaum Vered , Nevo Einat 
Published: February 2024

Purpose:
This study investigated the effectiveness of a storytelling-based morphological intervention program on the language and literacy knowledge and reading motivation of kindergarten children from low and mid socioeconomic status (SES) backgrounds. It also explored how these groups compared in change scores against a non-intervened high SES group.

Method:
Employing a cluster randomization approach, this study included 158 kindergarten children, comprising intervention and comparison groups from low and mid SES backgrounds, as well as a non-intervened high SES group. Assessments were conducted on morphological awareness (MA), print concepts, vocabulary, and reading motivation.

Results:
Children in the intervention groups showed better performance in MA and print concept scores than those in their respective comparison groups. The mid SES intervention group also displayed significant improvement in vocabulary and motivation scores compared to its counterpart. When examining the effects of SES on change scores, the low SES intervention group achieved superior results in vocabulary and print concept scores compared to both the mid SES intervention and the non-intervened high SES groups. For reading motivation, the mid SES group outperformed the low SES group.

Conclusions:
The morphological intervention program using storytelling positively impacts both the literacy skills and reading motivation of kindergarten children, especially those from low and mid SES backgrounds. This study emphasizes the significance of designing interventions that cater to the distinct educational needs of children from different SES backgrounds.
A practical ball‐grid‐array transition modelling methodology for accurate and fast multi‐interposer package simulation
Authors: Tang Lei , Li Kangrong , Zhou Xingshe , Yang Qiao , Pan Penghui 
Published: February 2024

AbstractAn equivalent circuit modelling methodology for the ball‐grid‐array (BGA) transition is proposed and validated with full‐wave electromagnetic simulation and measurement results. The BGA transitions modelled with the proposed methodology are validated to have a good accuracy up to 40 GHz. Unlike the existing BGA modelling methodologies which cannot model the BGA transition with short transmission lines within the anti‐pad region, the proposed methodology is developed from the practical BGA modelling scenario and models the irregular‐shape solder pads with transmission lines within the anti‐pad region. The BGA transitions modelled with the proposed methodology can be used for accurate and fast signal integrity simulations, analyses, and optimizations on 2.5D and 3D packaging. Additionally, factors impacting the accuracy of the equivalent circuit model are revealed by the proposed methodology.
Radial velocities from Gaia BP/RP spectra
Authors: Verberne Sill , Koposov Sergey E. , Rossi Elena Maria , Marchetti Tommaso , Kuijken Konrad , Penoyre Zephyr 
Published: February 2024

Aims. The Gaia mission has provided us full astrometric solutions for over 1.5B sources. However, only the brightest 34M of them have radial velocity measurements. This paper aims to close that gap by obtaining radial velocity estimates from the low-resolution BP/RP spectra that Gaia now provides. These spectra are currently published for about 220M sources, with this number to increase to the full ~2B Gaia sources with Gαία Data Release 4.
Methods. To obtain the radial velocity measurements, we fitted Gaia BP/RP spectra with models based on a grid of synthetic spectra. From this we obtained the posterior probability on the radial velocity for each object. Our measured velocities show systematic biases that depend mainly on the colours and magnitudes of stars. We corrected for these effects by using external catalogues of radial velocity measurements.
Results. We present a catalogue of about 6.4M sources with our most reliable radial velocity measurements and uncertainties of <300 km s−1 obtained from BP/RP spectra. About 23% of them have no radial velocity measurement from the Gaia RVS. Furthermore, we provide an extended catalogue that contains all 125M sources for which we were able to obtain radial velocity measurements. This catalogue, however, also contains a fraction of measurements for which the reported radial velocities and uncertainties are inaccurate.
Conclusions. Although typical uncertainties in the catalogue are significantly higher compared to those obtained with precision spec-troscopy instruments, the number of potential sources to which this method can be applied is orders of magnitude higher than any previous radial velocity catalogue. Further development of the analysis could therefore prove extremely valuable in our understanding of Galactic dynamics.