bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivery of Care for Pediatric Patients Receiving Blinatumomab: A Children’s Oncology Group Study
Authors: Withycombe Janice S. , Kubaney Holly R. , Okada Maki , Yun Christine S. , Gupta Sumit , Bloom Caylie , Parker Veronica , Rau Rachel E. , Zupanec Sue 
Published: November 2023

Background
Blinatumomab is an immunotherapy agent used in pediatric oncology for the treatment of B-lineage acute lymphoblastic leukemia. Administration of blinatumomab, via continuous 28-day infusion cycles, can present multiple decision points and challenges related to patient care. Nurses are at the forefront of coordinating and delivering care for patients receiving blinatumomab.

Objective
To describe the current state of practice across Children’s Oncology Group (COG) member institutions regarding blinatumomab administration in both inpatient and home/outpatient settings.

Methods
Between August and December 2021, a cross-sectional survey was used to determine current institutional practices related to blinatumomab administration. A single targeted respondent who was actively engaged in coordinating blinatumomab administration completed the survey on behalf of each COG institution.

Results
Survey participation rate was 78% (150/192). During the first 28-day blinatumomab cycle, 71 institutions (53%) reported patient hospital stays between 73 hours and 7 days; 42 (31%) reported hospital stays ≤72 hours, and only 12 (9%) reported hospitalization for the full 28-day infusion. Small- to medium-size institutions were more likely to report longer hospitalizations (P = .03). Most blinatumomab administration occurred in the outpatient setting, with low rates of unplanned clinic/emergency room visits.

Conclusions
The majority of COG institutions have navigated the complex coordination of care required for children to receive blinatumomab at home. Wide variations in practice were noted across institutions.

Implications for Practice
This study describes current institutional practices surrounding administration of 28-day blinatumomab infusions in children with leukemia and offers a starting point for institutional benchmarking and standardization of practice.
Foreign Accent Syndrome After COVID 19 Infection
Authors: Olguner Eker Ozlem , Gultekin Murat , Demirel Ozsoy Saliha 
Published: November 2023

Abstract
Foreign accent syndrome (FAS) is an extremely rare disorder characterized by the appearance of speech changes that are perceived by the speaker and listeners as an acquired foreign accent. It still remains a poorly understood condition. Three main types of FAS have been reported in the medical literature as neurogenic, psychogenic, and mixed type. Psychogenic FAS includes all cases of FAS in which an organic cause has not been identified and a clear psychological factor has been identified after careful clinical, neurological, and neuroradiological examination. Although the COVID-19 epidemic, which has been ongoing since February 2020, primarily manifests itself with upper respiratory tract infection findings, it is seen that it also causes a wide range of neurological and psychiatric signs and symptoms. In this study, a 42-year-old female patient who started to have speech disorder after COVID-19 infection is presented in the light of clinical history, diagnosis, and differential diagnosis literature findings.
Pathophysiological Hypothesis of COVID-19 Psychosis
Authors: Lisi Gisela Roxana Edith , Appiani Francisco , Basile María Eugenia , Garro Marcelo , Duarte Juan Manuel 
Published: November 2023

Abstract
In December 2019, a new coronavirus called SARS-CoV-2 was discovered in patients with pneumonia of unknown cause. Although respiratory symptoms mainly characterize infection by this virus, neuropsychiatric manifestations of the disease are becoming more and more frequent. Among them, the appearance of psychotic outbreaks in patients experiencing the infection or after a short time after it has resolved is remarkable. This narrative review aims to describe the possible relationship between SARS-CoV-2 and the onset of psychosis by developing the neurotropic capacities of the virus and analyzing the neurobiology of psychoses.
Drawing the Line Between Postacute Sequelae of COVID-19 and Functional Neurologic Disorders
Authors: Sales Paulo M.G. , Greenfield Melissa J. , Pinkhasov Aaron , Viswanathan Ramaswamy , Saunders Ramotse , Huremović Damir 
Published: November 2023

Abstract
Coronavirus disease 2019 (COVID-19) is an acute infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in its multiple variants that classically presents with cough, fatigue, fever, headache, myalgias, and diarrhea. As vaccination becomes widely available and infection rates facilitate herd immunity across the globe, more attention has been given to long-term symptoms that may persist after the index infection, which include impairments in concentration, executive dysfunction, sensory disturbances, depression, anxiety, fatigue, and cough, among other symptoms classified under the umbrella term of postacute sequelae of SARS-CoV-2 infection (PASC).
Functional neurologic disorder (FND), also known as conversion disorder and functional neurologic symptom disorder, refers to the presence of one or more symptoms of altered voluntary motor or sensory function that are incompatible with and not better explained by a known neurological or medical condition that causes significant distress and functional impairment. Although the diagnosis of FND may not require the identification of an underlying psychological stressor, being diagnosed with an FND can worsen stigma and shift attention and resources away from other medical concerns that should be concomitantly addressed.
This review summarizes the literature on the overlapping nature and discrimination of PASC from FND in COVID-19 survivors. Based on this, we develop a treatment framework that targets unique domains of these complex overlapping presentations, following a multidisciplinary approach with an individualized treatment plan inclusive of physical and psychological interventions focused on functional rehabilitation.
Poststroke Mania During the COVID-19 Pandemic
Authors: Nagamine Takahiko 
Published: November 2023

Abstract
The pandemic of coronavirus infection 2019 (COVID-19) is stressing people's daily lives and making them more susceptible to various mental illnesses. Depression and suicide attempt as well as, strangely enough, manic patients are on the rise. The main complication of COVID-19 infection is ischemic stroke. Multiple lacunar infarcts in the white matter of the right middle cerebral artery region induce an imbalance of blood flow in the left and right cerebral cortex and risk causing mania. The increase in mania during the COVID-19 must be considered not only a primary increase due to stress but also poststroke mania secondary to COVID-19 infection.
Psychological Stress and Coping Strategy Profiles Among Frontline Medical Workers During the COVID-19 Pandemic
Authors: Yan Lihua , Li Jiahuan , Lin Pingzhen , Sun Jiwei 
Published: November 2023

Abstract
This study aimed to explore coping strategy profiles used by frontline medical workers and the psychological stress reactions associated with each category, in the COVID-19 pandemic context. Participants were 651 frontline medical workers recruited between February and March 2020. Psychological stress reactions (e.g., anxiety, depression) and coping strategies were assessed and analyzed using latent profile analysis and linear regression. Participants had three coping strategy profiles: coping inadequately (28.9%), coping appropriately (64.4%), and coping excessively (6.7%). Compared with coping appropriately, those who coped inadequately and excessively had higher psychological stress reactions levels. Levels of anxiety, depression, and posttraumatic stress disorder in excessive-coping individuals were higher than those who coped inadequately. Our findings elucidate the effectiveness of different coping strategy profiles and provide insights for developing targeted interventions to mitigate stress among medical workers. In light of these results, we recommend implementing stress management programs tailored to specific coping strategy profiles.
Reliability and Minimal Detectable Change for Respiratory Muscle Strength Measures in Individuals With Multiple Sclerosis
Authors: Aguilar-Zafra Sandra , Fabero-Garrido Raúl , del Corral Tamara , López-de-Uralde-Villanueva Ibai 
Published: November 2023

Background and Purpose:
The test-retest reliability and minimal detectable changes (MDCs) for respiratory muscle strength measures have not been determined in individuals with multiple sclerosis (MS). This study determined the test-retest reliability and MDCs for specific respiratory muscle strength measures, as well as their associations with health-related quality of life (HRQoL), disability, dyspnea, and physical activity level measures in this population. In addition, the study examined differences in respiratory muscle strength between different degrees of disability.

Methods:
Sixty-one individuals with MS attended 2 appointments separated by 7 to 10 days. Respiratory muscle strength was evaluated by maximal inspiratory and expiratory pressures (MIP/MEP), HRQoL by EuroQol-5D-5L (index and visual analog scale [EQ-VAS]), disability by the Expanded Disability Status Scale, dyspnea by the Medical Research Council scale, and physical activity levels by the International Physical Activity Questionnaire.

Results:
Respiratory muscle strength measures had excellent test-retest reliability (ICC ≥ 0.92). The MDC for MIP is 15.42 cmH2O and for MEP is 17.84 cmH2O. Participants with higher respiratory muscle strength (MIP/MEP cmH2O and percentage of predicted values) had higher HRQoL (r = 0.54-0.62, P < 0.01, EQ-5D-5L index; r = 0.30-0.42, P < 0.05, EQ-VAS); those with higher expiratory muscle strength (cmH2O and percentage of predicted values) had lower levels of disability (r ≤ −0.66) and dyspnea (r ≤ −0.61). There were differences in respiratory muscle strength between different degrees of disability (P < 0.01; d ≥ 0.73).

Discussion and Conclusion:
Respiratory muscle strength measures provide excellent test-retest reliability in individuals with MS. MDCs can be interpreted and applied in the clinical setting. Low respiratory muscle strength can contribute to a poor HRQoL; specifically, expiratory muscle strength appears to have the strongest influence on disability status and dyspnea.
Effect of tuberculosis–HIV co-treatment on clinical and growth outcomes among hospitalized children newly initiating antiretroviral therapy
Authors: Cherkos Ashenafi S. , Cranmer Lisa M. , Njuguna Irene , LaCourse Sylvia M. , Mugo Cyrus , Moraa Hellen , Maleche-Obimbo Elizabeth , Enquobahrie Daniel A. , Richardson Barbra A. , Wamalwa Dalton , John-Stewart Grace 
Published: November 2023

Objective:
Evaluate effects of tuberculosis (TB)–HIV co-treatment on clinical and growth outcomes in children with HIV (CHIV).

Design:
Longitudinal study among Kenyan hospitalized ART-naive CHIV in the PUSH trial (NCT02063880).

Methods:
CHIV started ART within 2 weeks of enrollment; Anti-TB therapy was initiated based on clinical and TB diagnostics. Children were followed for 6 months with serial viral load, CD4%, and growth assessments [weight-for-age z-score (WAZ), height-for-age z-score (HAZ), and weight-for-height z-score (WHZ)]. TB-ART treated and ART-only groups were compared at 6 months post-ART for undetectable viral load (<40 c/ml), CD4% change, and growth using generalized linear models, linear regression, and linear mixed-effects models, respectively.

Result:
Among 152 CHIV, 40.8% (62) were TB-ART treated. Pre-ART, median age was 2.0 years and growth was significantly lower, and viral load significantly higher in the TB-ART versus ART-only group. After 6 months on ART, 37.2% of CHIV had undetectable viral load and median CD4% increased by 7.2% (IQR 2.0–11.6%) with no difference between groups. The TB-ART group had lower WAZ and HAZ over 6 month follow-up [WAZ −0.81 (95% CI: −1.23 to −0.38], P < 0.001; HAZ −0.15 (95% CI: −0.29 to −0.01), P = 0.030] and greater rate of WAZ increase in analyses unadjusted and adjusted for baseline WAZ [unadjusted 0.62 (95% CI: 0.18–1.07, P = 0.006) or adjusted 0.58 (95% CI: 0.12–1.03, P = 0.013)].

Conclusion:
TB–HIV co-treatment did not adversely affect early viral suppression and CD4+ recovery post-ART. TB-ART-treated CHIV had more rapid growth reconstitution, but growth deficits persisted, suggesting need for continued growth monitoring.
Association of age at antiretroviral therapy initiation with CD4+ : CD8+ ratio recovery among virally suppressed people with HIV
Authors: Holden Clare J. , Lampe Fiona C. , Burns Fiona M. , Chaloner Clinton , Johnson Margaret , Kinloch-De Loes Sabine , Smith Colette J. 
Published: November 2023

Objective:
To investigate the association of age at antiretroviral therapy (ART) initiation with CD4+ : CD8+ T-cell ratio in virally suppressed people with HIV on long-term ART, and to characterize potential CD4+ : CD8+ ratio recovery in this population by age.

Design:
A longitudinal study of people attending an HIV clinic at the Royal Free Hospital NHS Trust, London, who initiated ART between 2001 and 2015, and achieved and maintained HIV-1 viral suppression (viral load <1,000 copies/ml). The association of age group at ART initiation with CD4+ : CD8+ ratio at 5 and 10 years was assessed.

Methods:
Multivariable linear regression was used to investigate the relationship between age at ART initiation and log CD4+ : CD8+ ratio, adjusting for demographic factors (gender/HIV transmission route, ethnicity), baseline CD4+ count and calendar year.

Results:
The sample included 1859 people aged 20–78 (75% men, 56% white ethnicity). Overall, median CD4+ : CD8+ T-cell ratio increased from 0.24 at baseline to 0.77 at year 5 and 0.88 at year 10. Ratios increased among all age groups in unadjusted and adjusted models but increased less among older ages (baseline ages 60–69 and 70–79). Median ratios at year 5 were 0.85, 0.80, 0.72, 0.76, 0.6, and 0.44, respectively, among people aged 20–29, 30–39, 40–49, 50–59, 60–69 and 70–79 years at baseline.

Conclusion:
In a virally suppressed London population, age had a substantial impact on CD4+ : CD8+ ratio recovery, especially for those starting ART after age 60 years. Results may indicate the level of CD4+ : CD8+ ratio recovery possible in an HIV-positive, virally suppressed, aging population.
Does Dual-Energy Computed Tomography Material Decomposition Improve Radiomics Capability to Predict Survival in Head and Neck Squamous Cell Carcinoma Patients? A Preliminary Investigation
Authors: Bernatz Simon , Böth Ines , Ackermann Jörg , Burck Iris , Mahmoudi Scherwin , Lenga Lukas , Martin Simon S. , Scholtz Jan-Erik , Koch Vitali , Grünewald Leon D. , Koch Ina , Stöver Timo , Wild Peter J. , Winkelmann Ria , Vogl Thomas J. , Pinto dos Santos Daniel 
Published: November 2023

Objective
Our study objective was to explore the additional value of dual-energy CT (DECT) material decomposition for squamous cell carcinoma of the head and neck (SCCHN) survival prognostication.

Methods
A group of 50 SCCHN patients (male, 37; female, 13; mean age, 63.6 ± 10.82 years) with baseline head and neck DECT between September 2014 and August 2020 were retrospectively included. Primary tumors were segmented, radiomics features were extracted, and DECT material decomposition was performed. We used independent train and validation datasets with cross-validation and 100 independent iterations to identify prognostic signatures applying elastic net (EN) and random survival forest (RSF). Features were ranked and intercorrelated according to their prognostic importance. We benchmarked the models against clinical parameters. Intraclass correlation coefficients were used to analyze the interreader variation.

Results
The exclusively radiomics-trained models achieved similar (P = 0.947) prognostic performance of area under the curve (AUC) = 0.784 (95% confidence interval [CI], 0.775–0.812) (EN) and AUC = 0.785 (95% CI, 0.759–0.812) (RSF). The additional application of DECT material decomposition did not improve the model's performance (EN, P = 0.594; RSF, P = 0.198). In the clinical benchmark, the top averaged AUC value of 0.643 (95% CI, 0.611–0.675) was inferior to the quantitative imaging-biomarker models (P < 0.001). A combined imaging and clinical model did not improve the imaging-based models (P > 0.101). Shape features revealed high prognostic importance.

Conclusions
Radiomics AI applications may be used for SCCHN survival prognostication, but the spectral information of DECT material decomposition did not improve the model's performance in our preliminary investigation.
Utilization of Radiomics Features Extracted From Preoperative Medical Images to Detect Metastatic Lymph Nodes in Cholangiocarcinoma and Gallbladder Cancer Patients: A Systemic Review and Meta-analysis
Authors: Mirza-Aghazadeh-Attari Mohammad , Afyouni Shadi , Zandieh Ghazal , Yazdani Nia Iman , Mohseni Alireza , Borhani Ali , Madani Seyedeh Panid , Shahbazian Haneyeh , Ansari Golnoosh , Kim Amy , Kamel Ihab R. 
Published: November 2023

Objectives
This study aimed to determine the methodological quality and evaluate the diagnostic performance of radiomics features in detecting lymph node metastasis on preoperative images in patients with cholangiocarcinoma and gallbladder cancer.

Methods
Publications between January 2005 and October 2022 were considered for inclusion. Databases such as Pubmed/Medline, Scopus, Embase, and Google Scholar were searched for relevant studies. The quality of the methodology of the manuscripts was determined using the Radiomics Quality Score and Quality Assessment of Diagnostic Accuracy Studies 2. Pooled results with corresponding 95% confidence intervals (CIs) were calculated using the DerSimonian-Liard method (random-effect model). Forest plots were used to visually represent the diagnostic profile of radiomics signature in each of the data sets pertaining to each study. Fagan plot was used to determine clinical applicability.

Results
Overall sensitivity was 0.748 (95% CI, 0.703–0.789). Overall specificity was 0.795 (95% CI, 0.742–0.839). The combined negative likelihood ratio was 0.299 (95% CI, 0.266–0.350), and the positive likelihood ratio was 3.545 (95% CI, 2.850–4.409). The combined odds ratio of the studies was 12.184 (95% CI, 8.477–17.514). The overall summary receiver operating characteristics area under the curve was 0.83 (95% CI, 0.80–0.86). Three studies applied nomograms to 8 data sets and achieved a higher pooled sensitivity and specificity (0.85 [0.80–0.89] and 0.85 [0.71–0.93], respectively).

Conclusions
The pooled analysis showed that predictive models fed with radiomics features achieve good sensitivity and specificity in detecting lymph node metastasis in computed tomography and magnetic resonance imaging images. Supplementation of the models with biological correlates increased sensitivity and specificity in all data sets.
Multicenter Study of the Utility of Convolutional Neural Network and Transformer Models for the Detection and Segmentation of Meningiomas
Authors: Ma Xin , Zhao Lingxiao , Dang Shijie , Zhao Yajing , Lu Yiping , Li Xuanxuan , Li Peng , Chen Yibo , Mei Nan , Yin Bo , Geng Daoying 
Published: November 2023

Purpose
This study aimed to investigate the effectiveness and practicality of using models like convolutional neural network and transformer in detecting and precise segmenting meningioma from magnetic resonance images.

Methods
The retrospective study on T1-weighted and contrast-enhanced images of 523 meningioma patients from 3 centers between 2010 and 2020. A total of 373 cases split 8:2 for training and validation. Three independent test sets were built based on the remaining 150 cases. Six convolutional neural network detection models trained via transfer learning were evaluated using 4 metrics and receiver operating characteristic analysis. Detected images were used for segmentation. Three segmentation models were trained for meningioma segmentation and were evaluated via 4 metrics. In 3 test sets, intraclass consistency values were used to evaluate the consistency of detection and segmentation models with manually annotated results from 3 different levels of radiologists.

Results
The average accuracies of the detection model in the 3 test sets were 97.3%, 93.5%, and 96.0%, respectively. The model of segmentation showed mean Dice similarity coefficient values of 0.884, 0.834, and 0.892, respectively. Intraclass consistency values showed that the results of detection and segmentation models were highly consistent with those of intermediate and senior radiologists and lowly consistent with those of junior radiologists.

Conclusions
The proposed deep learning system exhibits advanced performance comparable with intermediate and senior radiologists in meningioma detection and segmentation. This system could potentially significantly improve the efficiency of the detection and segmentation of meningiomas.
Solitary Dural Metastasis From Neuroblastoma Detected by 123I-MIBG SPECT/CT
Authors: Lu Xia , Xu Yanfeng , Wang Wei , Yang Jigang 
Published: November 2023

Abstract

123I-MIBG SPECT/CT was performed for follow-up in an asymptomatic 8-year-old girl with a history of neuroblastoma. The images showed an unsuspected abnormal accumulation in the head, which was identified as a hyperdense lesion of the dura with increasing MIBG uptake, suggesting the possibility of metastasis from neuroblastoma. A brain MRI with contrast showed a remarkably enhanced lesion beside the confluence of sinuses, which mimicked meningioma. Results of the surgical pathology are consistent with the diagnosis of dural metastasis from neuroblastoma.
Penile Evaluation: An Illustrated Review
Authors: Bass David , Clancy Kathleen , Gupta Akshya , Dogra Vikram 
Published: November 2023

Abstract
High-frequency ultrasound is the imaging modality of choice for evaluating penile pathology because of its easy access, low cost, and patient tolerance (The Penis, Diagnostic Ultrasound, second edtion. Boca Raton: CRC Press; 2007:957–978). This pictorial review will illustrate the sonographic features of emergent and nonemergent penile conditions such as penile fracture, spongial tear, urethral injury, various types of priapism, erectile dysfunction, penile abscess, and Mondor disease.