bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traits of narcissistic vulnerability in adults with autism spectrum disorders without intellectual disabilities
Authors: Broglia Giovanni , Nisticò Veronica , Di Paolo Bianca , Faggioli Raffaella , Bertani Angelo , Gambini Orsola , Demartini Benedetta 
Published: November 2023

AbstractThe relationship between Autism Spectrum Disorders (ASD) and Narcissistic Personality Disorder (NPD), considering the dimensions of narcissistic grandiosity and vulnerability, represents an important differential diagnosis and potential ground of comorbidity, since both conditions show high grades of pervasiveness, a life‐long course, ego‐syntonic traits, and difficulties in building up and sustaining interpersonal relationships Although the co‐diagnosis rates, according to the categorical criteria in use, are limited (0%–6.4%), it is common to encounter diagnostic doubts in clinical practice. Here we investigated the dimensions of narcissistic vulnerability and grandiosity in a sample of 87 adults diagnosed with ASD without intellectual disabilities through the administration of the Pathological Narcissism Inventory‐52 Items (PNI‐52). The mean scores of our sample were compared with the normative distribution available in the literature, and we found that individuals with ASD scored significantly higher than neurotypical controls at the Total Score and at the Vulnerable Narcissism subscale, but not at the Grandiose Narcissism subscales. Demographic features did not influence these results. Vulnerable narcissism was significantly associated with the “Ritvo Autism and Asperger Diagnostic Scale ‐ Revised” subscale Social Relatedness. These findings could potentially be indicative of a greater comorbidity rate between the two disorders with respect to the one reported to date, possibly because DSM‐5 criteria are mainly focused on the grandiose dimension. Potential explanatory links between ASD phenomenology and vulnerable narcissism, such as the personality dimension of neuroticism, are discussed, together with the possible role of narcissistic vulnerability in mediating internalizing symptoms (e.g., anxiety, depression) in individuals with ASD.
FTO‐mediated ZNF687 accelerates tumor growth, metastasis, and angiogenesis in colorectal cancer through the Wnt/β‐catenin pathway
Authors: Li Junyi , Li Shixin , Xing Xiaoxiao , Liu Nini , Lai Suyu , Liao Daixiang , Li Jun 
Published: November 2023

AbstractColorectal cancer (CRC) is a common and lethal cancer. ZNF687 has been disclosed to take part in diversified cancers’ progression by serving as a facilitator. However, the detailed regulatory functions of ZNF687 in the CRC have not been investigated. This work is planned to probe the impacts of ZNF687 on CRC progression. The IHC, RT‐qPCR, and western blot assays were used to examine mRNA and protein gene expressions. The cell proliferation measurement was accompanied by a CCK‐8 assay. The Transwell assay was performed to evaluate cell invasion and migration. The angiogenesis ability was evaluated by a tube formation experiment. The m6A level was evaluated through MeRIP and m6A dot blot assays. The binding ability between ZNF687 and FTO (fat mass and obesity associated protein) was tested through an RIP assay. The β‐catenin nuclear translocation was assessed through an immunofluorescence assay. The tumor growth was evaluated through an in vivo assay. ZNF687 exhibited higher expression in CRC cells and resulted in a poor prognosis. Additionally, ZNF687 inhibition suppressed CRC cell proliferation, invasion, migration, and angiogenesis. Furthermore, the suppression of ZNF687 retarded the Wnt pathway. Through rescue assays, the reduced cell migration, proliferation, invasion, and angiogenesis mediated by ZNF687 knockdown could be reversed after BML‐284 (the activator of the Wnt pathway) treatment. Finally, it was explained that ZNF687 knockdown inhibited in vivo tumor growth. This study manifested that FTO‐mediated ZNF687 aggravated tumor growth, metastasis, and angiogenesis of CRC through Wnt/β‐catenin pathway. This finding may provide a hopeful molecular target for CRC treatment.
The early dorsal signal in vertebrate embryos requires endolysosomal membrane trafficking
Authors: Azbazdar Yagmur , De Robertis Edward M. 
Published: November 2023

AbstractFertilization triggers cytoplasmic movements in the frog egg that lead in mysterious ways to the stabilization of β‐catenin on the dorsal side of the embryo. The novel Huluwa (Hwa) transmembrane protein, identified in China, is translated specifically in the dorsal side, acting as an egg cytoplasmic determinant essential for β‐catenin stabilization. The Wnt signaling pathway requires macropinocytosis and the sequestration inside multivesicular bodies (MVBs, the precursors of endolysosomes) of Axin1 and Glycogen Synthase Kinase 3 (GSK3) that normally destroy β‐catenin. In Xenopus, the Wnt‐like activity of GSK3 inhibitors and of Hwa mRNA can be blocked by brief treatment with inhibitors of membrane trafficking or lysosomes at the 32‐cell stage. In dorsal blastomeres, lysosomal cathepsin is activated and intriguing MVBs surrounded by electron dense vesicles are formed at the 64‐cell stage. We conclude that membrane trafficking and lysosomal activity are critically important for the earliest asymmetries in vertebrate embryonic development.
Bioinspired 3D microprinted cell scaffolds: Integration of graph theory to recapitulate complex network wiring in lymph nodes
Authors: Chin Matthew H. W. , Reid Barry , Lachina Veronika , Acton Sophie E. , Coppens Marc‐Olivier 
Published: November 2023

AbstractPhysical networks are ubiquitous in nature, but many of them possess a complex organizational structure that is difficult to recapitulate in artificial systems. This is especially the case in biomedical and tissue engineering, where the microstructural details of 3D cell scaffolds are important. Studies of biological networks—such as fibroblastic reticular cell (FRC) networks—have revealed the crucial role of network topology in a range of biological functions. However, cell scaffolds are rarely analyzed, or designed, using graph theory. To understand how networks affect adhered cells, 3D culture platforms capturing the complex topological properties of biologically relevant networks would be needed. In this work, we took inspiration from the small‐world organization (high clustering and low path length) of FRC networks to design cell scaffolds. An algorithmic toolset was created to generate the networks and process them to improve their 3D printability. We employed tools from graph theory to show that the networks were small‐world (omega factor, ω = ‐0.10 ± 0.02; small‐world propensity, SWP = 0.74 ± 0.01). 3D microprinting was employed to physicalize networks as scaffolds, which supported the survival of FRCs. This work, therefore, represents a bioinspired, graph theory‐driven approach to control the networks of microscale cell niches.
An advanced course sequence in eukaryotic cell and molecular biology: A year‐long course where active learning and peer‐led groups resulted in higher learning gains and significant course passing scores
Authors: Soto Julio G. , French Rachael , Anand Sulekha 
Published: November 2023

AbstractWe developed an advanced, year‐long course sequence in eukaryotic cell and molecular biology in order to increase conceptual understanding. Three years of historical data from a one semester, traditional‐lecture, senior cell and molecular biology course (n = 237) were compared with 3 years of data collected from the year‐long course sequence (n = 176). There were significant content gains for the students who enrolled in the course sequence when pre‐ and post‐assessments were compared (p < 0.0001). There was an association between earning a C or better in the course sequence and 70% or higher in the post‐assessment instrument (p < 0.05). Final course grades for Bio 135A were calculated from three open ended exams and the percentage of correct answers on the clicker questions. For Bio135B, final grades were calculated from three open ended exams, clicker responses, a seven‐page literature review on an environmental carcinogen and its effects on signal transduction pathways, and a formal presentation of one of the research articles they used in the literature review. The students who took the second semester of the course passed at higher rates than the students who enrolled in the traditional‐lecture course (p < 0.05). Clicker answers to the research problem sets and the final course grades correlated significantly for both semesters of the course sequence (p < 0.01). We conclude that conceptually‐connected learning gains can be obtained when the content is taught in a format that includes short lectures and group work to solve research questions.
Significance of Industry 4.0 technologies in major work functions of manufacturing for sustainable development of small and medium‐sized enterprises
Authors: Narkhede Ganesh , Mahajan Sonal , Narkhede Rupesh , Chaudhari Tansen 
Published: November 2023

AbstractIndustry 4.0 (I4.0) has brought transformative changes in the manufacturing sector. This paper aims to provide a comprehensive analysis of the applications of I4.0 technologies in major work functions of small and medium‐sized enterprises (SMEs). Specifically, this review focuses on the suitability of I4.0 technologies in areas such as New Product Development, Supply Chain Management, Internal Logistics Management, Production Planning Execution and Control, Quality Management, and Maintenance Management. This study employs a systematic literature review (SLR) methodology to comprehensively analyze relevant sources to present valuable perspectives and practical suggestions customized to the requirements of different essential work functions within manufacturing SMEs. The findings of SLR indicate that Big Data Analytics (BDA), Robotics, and Automation are perceived as highly sustainable, on the other hand, blockchain and cloud technology are viewed as having lower sustainability from SMEs' point of view. The findings presented in this article have several theoretical and practical implications including technology selection and integration, and considering sustainability and ethics. This will allow SMEs to seamlessly integrate distinct I4.0 technologies along three dimensions: vertical, horizontal, and end‐to‐end digital integration. This article intends to provide an unbiased assessment to ascertain the landscape occupied by I4.0 in the context of SMEs. This article highlights the connection and synergy between I4.0 and SMEs as well as the pertinence of how advanced technologies of I4.0 can influence the business processes in manufacturing SMEs.
Psychological treatments for psychological distress in dementia with emphasis on acceptance and commitment therapy: A critical perspective
Authors: Robinson Amie , Moghaddam Nima 
Published: November 2023

AbstractBackgroundThis commentary offers a critical reflection on the current status of evidence‐based psychological treatments for psychological distress in dementia, with a particular emphasis on acceptance and commitment therapy (ACT).PurposeThe paper hypothesises several explanations, such as ethical dilemmas with recruitment and consent, and possible preconceptions surrounding the nature, scope and likelihood of therapeutic change in this population, for a lack of interventional research on people with dementia.ImplicationsWe highlight some recent developments in psychological therapy with people with dementia that are raising more questions and generating new outcome research.
Preliminary Evaluation of Wound Healing Potential ofLeonurus japonicusHoutt. Extracts
Authors: de Assunção Morais Laís Caroline , Koga Adriana , Klein Traudi , Kist Airton , de Oliveira Márcia Regina Paes , Cavalcante Lipinski Leandro , Beltrame Flávio Luís , Colerato Ferrari Priscileila 
Published: November 2023

AbstractLeonurus japonicusHoutt. is a medicinal plant popular in Brazil as “rubim”, used in local folk medicine for several applications as an anti‐inflammatory, antioxidant, analgesic, and antimicrobial phytomedicine. The traditional use for wound healing is related; however, few studies have evaluated the wound healing activity. Thus, this study aimed to analyse the popular indication of the hydroalcoholic and aqueous extracts ofL. japonicusaerial parts in a rat wound healing model. The initial chemical characterization was performed using flavonoid quantification and complemented with mass spectroscopy/chemometrics analysis. The wound‘s lesion contraction and tissue regeneration (histological study stained with hematoxylin‐eosin and picrosirius) were determined. Hydroalcoholic and aqueous extracts presented high flavonoid content, and mass spectrometry analysis of the extracts demonstrated the presence of compounds with a mass between 100–650, reinforcing the presence of polyphenolic constituents. The extracts ofL. japonicusimprove various wound healing phases, like inflammatory modulation, wound contraction, and collagen synthesis, resulting in faster healing in rats. These effects could be related to the extracts′ polyphenolic compounds.
A Tight Contact: The Expanding Application of Salicylaldehydes in Lysine‐Targeting Covalent Drugs
Authors: Mason Mattia , Belvisi Laura , Pignataro Luca , Dal Corso Alberto 
Published: November 2023

AbstractThe installation of aldehydes into synthetic protein ligands is an efficient strategy to engage protein lysine residues in remarkably stable imine bonds and augment the compound affinity and selectivity for their biological targets. The high frequency of lysine residues in proteins and the reversibility of the covalent ligand‐protein bond support the application of aldehyde‐bearing ligands, holding promises for their future use as drugs. This review highlights the increasing exploitation of salicylaldehyde modules in various classes of protein binders, aimed at the reversible‐covalent engagement of lysine residues.
Intravascular ultrasound‐guided STAR 2.0: A new technique for chronic total occlusion recanalization
Authors: Garbo Roberto , Iannaccone Mario , Bruno Francesco , Arioti Manfredi 
Published: November 2023

AbstractThe use of the subintimal space has allowed a massive advancement in the field of chronic total occlusion percutaneous coronary intervention (PCI). The STAR technique is the first of subintimal techniques. Despite a high acute success rate, follow‐up results showed unfavorable outcomes with half of the treated patients showing restenosis/reocclusion at 6 months. We present three cases in which a modification of the STAR technique guided by intravascular ultrasound (IVUS), namely the STAR 2.0, was used as a bailout for successful PCI of chronic total occlusions.
Reliability and validity of the Self‐Reflection and Insight Scale for psychologists and the development and validation of the revised short version
Authors: Banner S. E. , Rice K. , Schutte N. , Cosh S. M. , Rock A. J. 
Published: November 2023

AbstractSelf‐reflection is broadly considered a core competency for psychologists; however, there is an absence of measures of self‐reflection, limiting the extent to which self‐reflection can be assessed in both research and practice contexts. Whilst the Self‐Reflection and Insight Scale (Grant et al., 2002) has been validated in a range of formats with different populations, it has not yet been validated with psychologists. Further, the psychometric properties of a short version of the scale (Silvia, 2021) have not been examined for use with psychologists. This study tested the factor structure, internal consistency and convergent and divergent validity of the Self‐Reflection and Insight Scale with registered psychologists (N = 123), finding both the full scale and short version to have sound psychometrics. However, as there were low loading items across both versions of the measure, and the short version also excluded high‐loading items, the SRIS‐Revised (SRIS‐R) was formed through model improvement, retaining a total of 14 items. This revised version of the scale captures high loading items without redundancy of low‐loading items, resulting in a measure that parsimoniously captures the construct of self‐reflection as relevant to psychologists. The SRIS‐R demonstrated good internal consistency (α = .882), convergent, divergent and construct validity. Scores on the SRIS‐R were used to test whether there was a correlation between self‐reflection and years of professional registration, with this not being significant.
Recent Advances in Perylene Diimides (PDI)‐based Small Molecules Used for Emission and Photothermal Conversion
Authors: Sun Hua , Zhang Qichun 
Published: November 2023

AbstractPerylene diimides (PDIs) have received considerable attention as a versatile class of functional dyes owing to their flexible reaction sites and remarkable stability. Recent advances have enhanced our understanding of the fluorescence and photothermal conversion properties of PDI molecules. The interplay between radiative and nonradiative transitions controls the emission and heat generation processes in these molecules. This comprehensive overview summarizes the recent strategies for manipulating the structures of PDI molecules for fluorescence and photothermal conversion applications. Additionally, challenges and potential solutions associated with the usage of fluorescent and photothermal PDI molecules are discussed.
Corporate social responsibility as a framework for gender equality: Mapping of gender equality standards for sustainable development
Authors: Velasco‐Balmaseda Eva , de Celis Izaskun Larrieta‐Rubín , Izaguirre Nagore Embeita 
Published: November 2023

AbstractCorporations address gender equality issues in the context of corporate social responsibility (CSR) and sustainable development. As in other areas of CSR, various standards, certifications, and similar initiatives have been proposed to promote gender equality. Despite an increasing number of self‐regulation and signaling schemes being proposed, their study has been overlooked by the scholarly literature. This article tries to shed light on these standards through a two‐stage exploratory study. First, the main worldwide initiatives that focus on gender equality standards are scrutinized and mapped. Second, their main characteristics are analyzed, based on a content analysis of the information disclosed by organizations that foster the most relevant initiatives. A systematic analysis of relevant gender equality standards is provided. This work highlights a dispersion and lack of uniformity in terms of missions, results, measurement, and even the definition of gender equality or the term used to refer to it. No framework has prevailed. Gender equality standards lack gender mainstreaming and intersectionality is invisible. The business case appears to be the main driver of gender equality standards. The present study is one of the first attempts to thoroughly examine the institutional design of gender equality standards, their standard‐setting process as well as their enforcement. We suggest a rethink of the policies that promote the gender equality standards in organizations, as well as a need for collaborative work between managers and policymakers towards the use of common terminology, indicators, and uniformity regarding the terms to be certificated.
Transcriptome analysis and identification of genes related to environmental adaptation of Grylloprimevala jilina Zhou & Ren 2023
Authors: Zhou Yuxin , Zhou Lin , Li Qiuyao , Zhu Xiaoyan , Yu Zhongbo , Ke Haoqin , Chen Qi , Ren Bingzhong 
Published: November 2023

AbstractGrylloprimevala jilina is a true cave insect living in the dark areas of caves. It has the characteristics of sparse skin pigmentation, degeneration of the compound eyes and monocular eyes, and obvious preference for high‐humidity and low‐temperature environments. Given the highly specialized, rare, and limited distribution, G. jilina is considered an endangered species and also a first‐level national protected insect in China. Cave creatures often undergo dramatic morphological changes in their sensory systems to adapt to the cave environment. Most previous studies mainly focused on morphological adaptive changes in cave insects, and only a few studied the changes at the gene level. In this study, we performed transcriptome analysis of G. jilina and constructed phylogenetic trees of genes that are related to environmental adaptation, including chemosensory, visual‐related, reproduction‐related, temperature adaptation‐related, and winged morph differentiation‐related genes. Besides, the expression levels of environmental adaption‐related genes in different tissues, including antennae, heads, thoraxes, abdomens, legs, and tails, were analyzed. The results showed the loss of chemosensory genes and vision‐related genes, the conservation of reproduction‐related genes and temperature adaptation‐related genes, and the conservation of wing‐related genes despite the loss of wings, and the results were consistent with other cave insects. The identification and expression study of genes possibly related to the environmental adaptability in G. jilina provided basic data for the protection of this endangered species and increased knowledge about insect evolution in general.
Placebo analgesia in physical and psychological interventions: Systematic review and meta‐analysis of three‐armed trials
Authors: Hohenschurz‐Schmidt David , Phalip Jules , Chan Jessica , Gauhe Greta , Soliman Nadia , Vollert Jan , Lunde Sigrid Juhl , Vase Lene 
Published: November 2023

AbstractBackgroundThe magnitude of placebo effects from physical and psychological ‘sham’ is unknown but could impact efficacy trials and treatment understanding. To quantify placebo effects, this systematic review of three‐armed randomised controlled trials (RCTs) of physical and psychological interventions for pain compared outcomes in ‘sham’ control intervention and non‐exposure arms.MethodsRCTs with treatment, ‘sham’ control intervention, and non‐exposure groups were included, enrolling adults with any pain. A protocol was pre‐registered (PROSPERO: CRD42023413324), and twelve databases searched from 2008 to July 2023. Trial methods and blinding were analysed descriptively and risk of bias assessed. Meta‐analysis of pain measures at short‐, medium‐ and long‐term was performed with random‐effects models of standardised mean differences (SMD).Studies were sub‐grouped according to control intervention type.ResultsSeventeen RCTs were included. The average short‐term placebo effect was small (0.21 SMD, 0.1–0.33 95% CI, p = 0.0002, 1440 participants). It showed no heterogeneity (Tau2 = 0.1, I2 = 11%, p = 0.3), preventing meta‐regression analyses of effect modifiers. However, sub‐group analyses revealed larger placebo effects in manual control interventions compared to disabled devices and miscellaneous control interventions. Overall, placebo analgesia accounted for 39% of treatments’ short‐term effectiveness. No placebo effects were found at medium‐term (7 RCTs, 381 participants) or long‐term follow‐up (3 RCTs, 173 participants).ConclusionsThe observed placebo analgesia has mechanistic and methodological implications, though its clinical importance may be limited. Control intervention design affects placebo effects, highlighting the importance of considering methodology in RCT interpretation. Review limitations include a small number of long‐term studies and sample heterogeneity.SignificanceThis systematic review directly quantifies placebo effects from physical and psychological ‘sham’ control interventions and compares them to treatments’ overall effectiveness. By doing so, the review enhances our understanding of placebo effects, their relative contribution in clinical trials, and their susceptibly to trial design. It poses further questions regarding the influence of blinding, participant expectations, and features of the therapeutic context. Overall, the insights provided by this review carry methodological significance and are important for the interpretation and synthesis of efficacy trials in this field.