bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects often overlooked in lipid oxidation in oil‐in‐water emulsions: Agitation conditions and headspace‐to‐emulsion ratio
Authors: Cengiz Alime , Hennebelle Marie , Berton‐Carabin Claire , Schroën Karin 
Published: November 2023

AbstractThe effects of the agitation conditions and headspace‐to‐emulsion volume ratio on lipid oxidation in emulsions can be considerable, but have not been systematically investigated yet. In the current paper, lipid oxidation was monitored in model oil‐in‐water (O/W) emulsions at pH 4.0 and 25°C in the presence of 200 μM iron sulfate. The formation of primary (conjugated dienes and hydroperoxides) and secondary (p‐anisidine value and TBARS) oxidation products confirmed that using rotating or shaking devices doubled the rate of oxidation product formation compared to a non‐agitated system, as a result of enhanced oxygen transfer. Furthermore, we found that a higher headspace‐to‐emulsion volume ratio at least doubled the rate of lipid oxidation due to a higher amount of oxygen available per mass of oil, which is in agreement with the kinetics of the reaction. This indicates that the variation in literature data on lipid oxidation in emulsions can be attributed to differences in mixing conditions and volume ratios. These factors are crucial and should be reported systematically along with the agitation conditions, and sampling method. This will enable a better comparison of literature information.
Epigenetic regulation of craniofacial development and disease
Authors: Shull Lomeli C. , Artinger Kristin B. 
Published: November 2023

AbstractBackgroundThe formation of the craniofacial complex relies on proper neural crest development. The gene regulatory networks (GRNs) and signaling pathways orchestrating this process have been extensively studied. These GRNs and signaling cascades are tightly regulated as alterations to any stage of neural crest development can lead to common congenital birth defects, including multiple syndromes affecting facial morphology as well as nonsyndromic facial defects, such as cleft lip with or without cleft palate. Epigenetic factors add a hierarchy to the regulation of transcriptional networks and influence the spatiotemporal activation or repression of specific gene regulatory cascades; however less is known about their exact mechanisms in controlling precise gene regulation.AimsIn this review, we discuss the role of epigenetic factors during neural crest development, specifically during craniofacial development and how compromised activities of these regulators contribute to congenital defects that affect the craniofacial complex.
The role of social capital, resilience, and network complexity in attaining supply chain sustainability
Authors: Chowdhury Md Maruf Hossan , Islam Mohammad Tarikul , Ali Imran , Quaddus Mohammed 
Published: November 2023

AbstractSupply chain social capitals argued to be the driver for attaining sustainability along the supply chain. However, the role of network complexity and supply chain resilience to transform supply chain social capitals into sustainability remains poorly understood. We draw from social capital theory to argue that supply chain resilience is the mechanism to curb negative effects of network complexity to transform supply chain social capital into supply chain sustainability. Hypotheses were tested employing structural equation modeling technique on a sample (n = 274) of Bangladeshi apparel suppliers, and supplemented by the fuzzy set qualitative comparative analysis to identify all plausible underlying causal configurations. Our results suggest that supply chain social capitals positively influence supply chain sustainability both directly and indirectly via supply chain resilience. Contrary to our hypothesis, we found that network complexity in the presence of supply chain resilience positively influences social capitals to bolster supply chain sustainability. Findings of this research imply that supply chain resilience is a crucial conduit that facilitates leveraging supply chain social capitals as well as withstanding challenges that emerge from network complexity to embolden supply chain sustainability. Findings of this research provide novel insights to existing literature by exploring the complex dynamisms and reaffirming the interrelationships among the four vital constructs of supply chain literature. Our finding can help supply chain managers to improve resilience and sustainability.
Musculus pterygoideus proprius: A meta‐analysis
Authors: Mandal Gaurav , Montalbano Michael , Natsis Konstantinos , Piagkou Maria , Tubbs R. Shane , Loukas Marios 
Published: November 2023

AbstractThe pterygoideus proprius muscle can be found incidentally in the infratemporal fossa, where it is spatially associated with the muscles of mastication, the maxillary artery, and the trigeminal nerve and its branches. Anatomists have described the muscle in various ways over the past 160 years, chiefly as a musculotendinous structure that originates from the infratemporal crest of the sphenoid bone and inserts into the lateral pterygoid plate and the lateral pterygoid muscle. It is present in non‐human primates, albeit rarely, with similar anatomical findings. Embryologically, the pterygoideus proprius is thought to have developed from the first pharyngeal arch mesenchyme along with other muscles of mastication. Its close association with the maxillary artery and trigeminal nerve suggests possible clinical significance in trigeminal neuralgia and temporomandibular joint disorders. The literature was reviewed systematically to detail the historical background of research on the pterygoideus proprius muscle and explain its morphology, prevalence, embryology, and potential clinical significance. Despite its rarity, we propose that it is important to recognize its presence when the infratemporal fossa is approached.
Cost‐effectiveness analysis of tumor‐infiltrating lymphocytes biomarkers guiding chemotherapy de‐escalation in early triple‐negative breast cancer
Authors: Li Shiqi , Liu Yuhan , Zhang Peigen , Wang Mengmeng , Sun Lihua 
Published: November 2023

AbstractBackgroundTo accelerate the clinical translation of tumor‐infiltrating lymphocytes (TILs) biomarkers for guiding chemotherapy de‐escalation in early‐stage triple‐negative breast cancer (TNBC), cost‐effectiveness evidence is essential but has not been investigated. We intend to evaluate the cost‐effectiveness of using TILs to guiding chemotherapy de‐escalation in patients with early‐stage TNBC from the perspective of the Chinese health service system.MethodsThe hybrid decision‐tree‐Markov model was designed to compare the cost‐effectiveness of cytotoxic chemotherapy guided by whether TILs assay was performed in 50‐year‐old female patients with early‐stage TNBC over a lifetime horizon. In Strategy (1), if TILs testing was performed, patients with TILs values exceeding 30% could be spared from chemotherapy. In Strategy (2), where no TILs testing was performed, all patients were administered chemotherapy following China's clinical practices. Based on the algorithm built by Guyot, the individual patient data were reconstructed from the published Kaplan–Meier curves, and the survival functions were calculated by parametric methods. Cost estimates were valued in Chinese yuan (as per rates in 2022).ResultsIn 50‐year‐old female patients with early‐stage TNBC, Strategy (1), which employs TILs testing to guide cytotoxic chemotherapy yielded an additional 0.47 quality‐adjusted life years (QALYs) and saved 40,976 yuan, with an incremental cost‐effectiveness ratio (ICER) of −87,182.98 yuan per QALY gained compared with Strategy (2). This indicates that compared with Strategy (2), Strategy (1) is the dominant scheme. The results were sensitive to utility parameters, discount rates, and treatment costs after relapse. At a willingness‐to‐pay threshold of 85,700 yuan (based on GDP per capita) per QALY, the probability of TILs being cost‐effective was almost 100%.ConclusionsThe application of biomarkers (TILs) to guide decisions for chemotherapy de‐escalation is a cost‐effective strategy for early‐stage TNBC patients and deserves to be widely promoted in clinical practice.
Region of origin and cervical cancer stage in multiethnic Hispanic/Latinx patients living in the United States
Authors: Dinicu Andreea Ioana , Dioun Shayan , Goldberg Mandy , Crookes Danielle M. , Wang Yongzhe , Tergas Ana I. 
Published: November 2023

AbstractBackgroundHispanic/Latinx people have the second highest cervical cancer incidence rates in the U.S. However, there is a lack of disaggregated data on clinical outcomes for this diverse and populous group, which is critical to direct resources and funding where they are most needed. This study assessed differences in stage at diagnosis of cervical cancer among Hispanic/Latinx subpopulations and associated factors.MethodsWe analyzed patients with primary cervical cancer from 2004 to 2019 in the National Cancer Database. Hispanic/Latinx patients were further categorized into Mexican, Puerto Rican (PR), Cuban, Dominican, and Central/South American, as per standard NCDB categories, and evaluated based on stage at diagnosis and sociodemographic characteristics. Multinomial logistic regression quantified the odds of advanced stage at presentation. Regression models were adjusted for age, education, neighborhood income, insurance status, and additional factors.ResultsHispanic/Latinx cervical cancer patients were more likely to be uninsured (18.9% vs. 6.0%, p < 0.001) and more likely to live in low‐income neighborhoods (28.6% vs. 16.9%, p < 0.001) when compared to non‐Hispanic White populations. Uninsured Hispanic/Latinx patients had 37.0% higher odds of presenting with regional versus localized disease (OR 1.37; 95% CI, 1.19–1.58) and 47.0% higher odds of presenting with distant versus. Localized disease than insured patients (OR 1.47; 95% CI, 1.33–1.62). When adjusting for age, education, neighborhood income, and insurance status, PR patients were 48% more likely than Mexican patients to present with stage IV versus stage I disease (OR 1.48; 95% CI, 1.34–1.64).ConclusionDisaggregating health data revealed differences in stage at cervical cancer presentation among Hispanic/Latinx subpopulations, with insurance status as a major predictor. Further work targeting structural factors, such as insurance status, within specific Hispanic/Latinx subpopulations is needed.
In‐Silico Selection of Wound‐Healing Plant Secondary Molecules and Their Pro‐Healing Activities on Experimental Models
Authors: Casadiego Omar , Macias Oscar , García Laura , Sanabria‐Chanaga Elkin , Baay‐Guzmán Guillermina J. , Mantilla Julio Cesar , Escobar Patricia 
Published: November 2023

AbstractThis study explored the potential of plant‐derived molecules (PDMs) as a medicinal treatment for skin wounds. To assess their healing properties, 34 potential drug molecules (PDMs) and ten therapeutic targets were subjected to molecular docking and dynamics analysis, with allantoin used as a standard compound. Although aristolochic acid had the most potent inhibitory effect, its toxicity made it unsuitable for testing on cells and mice. Therefore, β‐caryophyllene (BC) and caryophyllene oxide (BCoxide) were chosen for further testing. The results showed that BC‐treated HaCat cells had significantly improved scratch area closure, and both BC and BCoxide treatment produced positive effects such as reduced dermal cellularity and mast cells, decreased levels of inflammation markers IL‐6 and TNF‐α, and an increase in collagen deposition in mice tissues. However, these treatments did not accelerate wound healing. This study suggests that the PDMs selected based on in‐silico results have significant potential for pro‐healing abilities. It is essential to conduct further research to confirm our findings.
Cistadesertosides B−E, Four New Diastereomeric Lignan Glycosides from the Stems of Cultural Cistanche deserticola in Tarim Desert
Authors: Nan Ze‐Dong , Zhu Yi‐Dong , Deng Chao‐Fan , Yang Jing‐Lin , Ma Xiao‐Li , Jiang Zhi‐Bo , Jiang Yong , Tu Pengfei 
Published: November 2023

AbstractFour previously undescribed diastereomeric lignan glycosides, namely cistadesertosides B−E (1–4) were isolated from the stems of cultural Cistanche deserticola in Tarim desert. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, HR‐ESI‐MS, 1D and 2D NMR, circular dichroism (CD) data and chemical degradation. The in vitro anti‐inflammatory activity of the isolates was also investigated. It showed that compounds 3 and 4 exhibited potential effects with IC50 values of 21.17 μM and 26.97 μM, respectively (positive control quercetin, IC50, 10.01 μM).
Integrated Electrochemical and Optical Biosensing in Organs‐on‐Chip
Authors: Tawade Pratik , Mastrangeli Massimo 
Published: November 2023

AbstractDemand for biocompatible, non‐invasive, and continuous real‐time monitoring of organs‐on‐chip has driven the development of a variety of novel sensors. However, highest accuracy and sensitivity can arguably be achieved by integrated biosensing, which enables in situ monitoring of the in vitro microenvironment and dynamic responses of tissues and miniature organs recapitulated in organs‐on‐chip. This paper reviews integrated electrical, electrochemical, and optical sensing methods within organ‐on‐chip devices and platforms. By affording precise detection of analytes and biochemical reactions, these methods expand and advance the monitoring capabilities and reproducibility of organ‐on‐chip technology. The integration of these sensing techniques allows a deeper understanding of organ functions, and paves the way for important applications such as drug testing, disease modeling, and personalized medicine. By consolidating recent advancements and highlighting challenges in the field, this review aims to foster further research and innovation in the integration of biosensing in organs‐on‐chip.
Differences in clinicopathological characteristics between lipohypertrophy and localized insulin‐derived amyloidosis: A scoping review
Authors: Mukai Kanae , Tanno Hiromasa , Sugama Junko , Yanagita Toshihiko , Kanno Emi 
Published: November 2023

AbstractInsulin is used as a therapeutic agent in patients with diabetes, and cutaneous lipohypertrophy (LH) and localized insulin‐derived amyloidosis (LIDA) are well‐known adverse effects associated with insulin injections. The clinical implications, management, assessment methods, and pathological differentiation of LH and LIDA have been recently updated. This review was to update our knowledge of the pathological differentiation, effects of insulin absorption, hypoglycemic events, and recent assessment methods for LH and LIDA. A scoping review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for Scoping Reviews guidelines. Original studies and case reports in English were also included. PubMed and Scopus databases were searched for keywords to identify papers published up to January 2022. A total of 113 studies were identified through a database search, and 31 were eligible for inclusion in this scoping review. In the 31 studies included in this review, patients with type 2 diabetes had high frequencies of LH and LIDA. LH outcome parameters were assessed using pathological findings and imaging. LIDA is mainly determined by pathological methods, such as hematoxylin and eosin and Congo red staining. Several in vitro and in vivo LIDA models of LIDA have been developed. These results suggest that pathological analysis is required to identify LH and LIDA. It is important to consider LIDA, as it likely influences insulin adsorption and glycemic control. Although several studies have evaluated the LIDA process, little is known about the mechanisms underlying the development of adverse effects associated with insulin injections.
Bidentate Ligand Driven Intramolecularly Te…O Bonded Organotellurium Cations from Synthesis, Stability to Catalysis
Authors: Jain Saket , Satpute Saurabh Sandip , Jha Raushan Kumar , Patel Mili Sanjeev , Kumar Sangit 
Published: November 2023

AbstractA new series of unsymmetrical phenyl tellurides derived from 2‐N‐(quinolin‐8‐yl) benzamide ligand has been synthesized in a practical manner by the copper‐catalyzed method by using diaryl ditelluride and Mg as a reductant at room temperature. In order to augment the Lewis acidity of these newly formed unsymmetrical monotellurides, these have been transformed into corresponding unsymmetrical 2‐N‐(quinolin‐8‐yl)benzamide tellurium cations. Subsequently, these Lewis acidic tellurium cations were used as chalcogen bonding catalysts, enabling the synthesis of various substituted 1,2‐dihydroquinolines by activating ketones with anilines under mild conditions. Moreover, the synthesized 2‐N‐(quinolin‐8‐yl)benzamide phenyl tellurium cation has also catalyzed the formation of β‐amino alcohols in high regioselectivity by effectively activating epoxides at room temperature. Mechanistic insight by 1H and 19F NMR study, electrostatic surface potential (ESP map), control reaction in which tellurium cation reacted explosively with epoxide, suggested that the enhanced Lewis acidity of tellurium center seems responsible for efficient catalytic activities under mild conditions enabling β‐amino alcohols with excellent regioselectivity and 1,2‐dihydroquinolines with trifluoromethyl, nitro, and pyridylsubstitution, which were difficult to access.
Size Determination of Organic Cages by Diffusion NMR Spectroscopy
Authors: Ivanova Svetlana , Adamski Paul , Köster Eva , Schramm Louis , Fröhlich Rebecca , Beuerle Florian 
Published: November 2023

AbstractReliable structure elucidation of covalent organic cage compounds remains challenging as routine analysis might leave ambiguities. Diffusion‐ordered NMR spectroscopy (DOSY) allows insight into the molecular size and mass of the species present in solution, but a systematic evaluation of the diffusion behavior for cage assemblies is rarely considered. Here we report the synthesis of four series of covalent organic cages based on tribenzotriquinacenes and diboronic acids with varying geometry and exohedral substituents. We provide a guideline for the consistent measurement of diffusion coefficients from 1H‐DOSY NMR spectroscopy, which was utilized to study the diffusion behavior for the whole set of cages and selected examples from the literature. For structurally similar cages, a linear correlation between the solvodynamic volume and the molecular mass allows precise size determination. For more complex systems, multiple parameters, such as window size or rigid exohedral functionalization. further modulate cage diffusion in solution.
Electronic Modulation in Homonuclear Dual‐Atomic Catalysts for Enhanced CO2 Electroreduction
Authors: Shi Wen‐Jie , Wang Yu‐Chen , Tao Wei‐Xue , Zhong Di‐Chang , Lu Tong‐Bu 
Published: November 2023

AbstractHomonuclear dual‐atomic catalysts showcase unique electronic modulation due to their dual metal centres, providing new direction in development of efficient catalysts for CO2 electroreduction. This article highlights a few cutting‐edge homonuclear dual‐atomic catalysts, focusing on their inherent advantages in efficient and selective CO2 electroreduction, to spotlight the potential application of dual‐atomic catalysts in CO2 electroreduction.
A high‐dose, depigmented polymerized birch pollen extract for subcutaneous allergen immunotherapy has a favourable efficacy/safety ratio
Authors: Pfaar Oliver , Sager Angelika , Mösges Ralph , Worm Margitta 
Published: November 2023

AbstractBackgroundSubcutaneous allergen immunotherapy (SCIT) with depigmented, polymerized (DPP) birch pollen extract has been marketed at doses of up to 1000 DPP units/mL since 2001. We sought to determine the dose‐dependent efficacy of a DPP birch pollen extract formulation in patients suffering from birch‐pollen‐induced allergic rhinitis or rhinoconjunctivitis with or without intermittent asthma.MethodsA titrated conjunctival provocation test (CPT) was applied as a surrogate marker. This Phase II randomized, double‐blind, parallel‐group, dose‐ranging clinical trial was performed at 39 centres in Germany, Lithuania and Poland. After randomization to four dose‐level groups (100, 1000, 5000 and 10,000 DPP units/mL) and up‐dosing, participants received maintenance SCIT with five monthly subcutaneous injections. The primary endpoint was the proportion of patients in whom a higher concentration of birch pollen (vs. baseline) was needed to elicit a positive CPT.ResultsThree hundred forty‐three patients were included (mean (range) age: 42.6 (19–70)). The highest CPT responder rates were seen in the higher dose‐level groups. In the intention‐to‐treat analysis, the difference between the 100 and 10,000 groups was statistically significant (p = 0.0118). Although the proportion of patients with ≥1 treatment‐emergent adverse events increased with the dose, almost all these events were mild (65.6%) or moderate (18.5%).ConclusionJudging by the results of a CPT, the efficacy/safety ratio in SCIT appears to be favourable for a high‐dose‐level preparation of a DPP birch pollen extract.
Data‐driven evidence shows truthful caregiver histories and significant overdiagnosis of abusive head trauma
Authors: Brook Chris B. 
Published: November 2023

AbstractObjectiveWe analyzed the veracity of caregiver‐provided histories when infants present with intracranial pathologies and abusive head trauma (AHT) is suspected.MethodsA comparison of medical findings is made using data from 335 infants with acute intracranial pathologies and no extracranial findings associated with abuse. Two null hypotheses were tested: (1) that cases where caregivers reported accidental trauma have similar medical findings to independently witnessed accidents; and (2) that cases where caregivers reported no trauma have similar medical findings as cases where caregivers reported accidental trauma.ResultsThe first null hypothesis is not rejected, corroborating caregiver histories of accidental trauma, yet such cases are diagnosed as AHT at significantly higher rates than accidents witnessed by unbiased independent observers. The second null hypothesis is rejected, corroborating caregiver histories that no trauma occurred.ConclusionsData suggest that caregivers can provide valuable diagnostic information when infants present with acute intracranial pathologies and suggest substantial rates of misdiagnosis of AHT.
Fractional cuckoo search invasive weed optimized neural network for data classification
Authors: Rathod Nilesh , Wankhade Sunil 
Published: November 2023

SummaryThe progression of organizing and classifying data components based on pre‐established criteria is known as data classification. In data classification problems, machine learning methods are frequently used. Although the ability of an algorithm to learn is essential, the recognition quality of algorithms is undoubtedly a key indicator. However, the error made in the beginning is significant, and if it is not rectified then, it causes chaos in data classification. In this research, a fractional hybrid optimization is created with a feed‐forward neural network (FFNN) for the data classification. The pre‐processing of the medical data involves the imputation of missing values and the log transformation. In the feature selection process, the chord distance and the Jaro‐Winkler distance are both employed to choose the important features. The FFNN classifier is used to classify the data, which is trained using the hybrid optimization method, namely the developed Fractional Cuckoo search Invasive Weed Optimization algorithm (FCSIWO). The fractional concept, Invasive Weed Optimization (IWO) algorithm, and Cuckoo search (CS) algorithm are combined to create the FCSIWO. When compared to existing data classification models, the developed technique achieved an optimal sensitivity of 0.9463, an optimal accuracy of 0.9440, and an optimal specificity of 0.9422.