bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investment Decisions: Are Financial Knowledge, Risk Tolerance and Experience Important?
Authors: Putri Grisvanda Devinta , Purwidianti Wida , Innayah Maulida Nurul , Alfalisyado  
Published: January 2024

Aims: This research aims to determine whether Financial Knowledge, Risk Tolerance and Experience significantly influence Investment Decisions, especially for heads of families in Purbalingga Regency.
Study Design: Heads of families in Purbalingga District, Central Java, Indonesia.
Place and Duration of Study: The research was conducted for three months in Purbalingga District with 20,552 Heads of Families.
Methodology: This research method uses the SEM (Structural Equation Modeling) analysis method with the Partial Least Square (PLS) approach. Each hypothesis is tested to understand the relationship between variables. To test the validity and reliability of research using an outer model. Hypothesis testing uses inner models.
Results: Financial knowledge influences investment decisions. Risk Tolerance does not affect Investment Decisions. And experience influences investment decisions.
Conclusion: Financial Knowledge and Experience influence family investment decisions in Purbalingga Regency, Central Java, Indonesia. This happens because the higher the respondent's financial knowledge, the better their ability to predict investments and choose the right type of investment so that they can generate profits. Experience also provides valuable lessons for respondents, helping them determine the right time, investment amount and type of investment. However, Risk Tolerance does not have a significant influence because the culture of the people in Purbalingga Regency, Central Java, prefers to invest in real assets such as land, rice fields and the business world because they consider it a desirable form of wealth.
Examining the effects of repeated pesticide exposure on bumblebee queen survival and reproduction
Authors: Morrison Morgan A. , Linguadoca Alberto , Šima Peter , Brown Mark J. F. 
Published: January 2025

Abstract

Bees are key pollinators, and thus declines in their populations around the world may lead to negative consequences for both the environment and agricultural systems. While these declines are caused by multiple factors, the use of pesticides in agricultural systems has been identified as a key potential driver.

Most bee species have an annual life cycle, with the potential for pesticide exposure throughout their life span. However, most studies have looked at a single exposure point within a season. Bumblebees, like most annual species, have an overwintering stage—which in their case is completed by bumblebee queens. Exposure to pesticides can be experienced by queens both before and after physiologically stressful periods such as hibernation and during nest foundation. This multi‐staged exposure may have increased impacts on bumblebee queens' colony foundation and reproductive output and therefore colony success. However, studies of such repeated exposures are lacking.

Here, we look at the effects of an unstudied, yet biologically likely exposure regime. We exposed bumblebee queens to the insecticide sulfoxaflor at 65.5 ppb for 4 days both before and after hibernation, using a fullycrossed design, in order to assess the impact of such repeated exposure on survival and reproductive fitness.

We observed queens through two important life stages, hibernation and colony foundation, following field realistic exposures to sulfoxaflor. We measured the effects on hibernation success, the likelihood of colony foundation and brood production. We found that neither exposure to sulfoxaflor pre‐ or post‐hibernation, nor their combination, impacted hibernation survival or colony foundation.

Practical Implication: Our study is the first to highlight the repeated pesticide exposure bumblebee queens experience over different stages of their life cycle. Our results suggest that single or repeated exposure to dietary sulfoxaflor alone, albeit at a conservative field‐realistic profile, is unlikely to impact queen health at key points in their life cycle. Future studies should explicitly incorporate repeated exposure across life cycle stages when assessing the impacts of anthropogenic stressors on bee health.
A Simplified Adaptive Fixed Time Control of Pure‐Feedback Stochastic Nonlinear Systems Subject to Full State Constraints
Authors: Wang Nan , Tao Fazhan , Fan Pengyu , Li Mengyang , Fu Zhumu 
Published: January 2025

ABSTRACTIn this paper, a novel fixed time adaptive fuzzy control scheme for pure‐feedback stochastic nonlinear systems with full state constraints is proposed based on dynamic surface control (DSC) technique and barrier Lyapunov functions (BLFs) method. Firstly, the mean value theorem is utilized to transform the pure‐feedback structure of the considered systems into strict‐feedback ones, which make it possible for the utilization of backstepping method to design the controller. Then, DSC technique is used to reduce the computational complexity problem caused by backstepping method. Fuzzy logic systems are exploited to approximate the unknown nonlinear functions. Moreover, combine BLFs method with fixed time stability theorem, the fixed time adaptive fuzzy controller is constructed, which guarantees that all states do not violate the prescribed constraints and all signals are semi‐globally uniform ultimately bounded. Finally, a simulation example is given to verify the effectiveness of the studied control.
Integrating Humidity‐Resistant and Colorimetric COF‐on‐MOF Sensors with Artificial Intelligence Assisted Data Analysis for Visualization of Volatile Organic Compounds Sensing
Authors: Ouyang Qin , Rong Yanna , Xia Gaofan , Chen Quansheng , Ma Yujie , Liu Zhonghua 
Published: January 2025

AbstractDirect visualization and monitoring of volatile organic compounds (VOCs) sensing processes via portable colorimetric sensors are highly desired but challenging targets. The key challenge resides in the development of efficient sensing systems with high sensitivity, selectivity, humidity resistance, and profuse color change. Herein, a strategy is reported for the direct visualization of VOCs sensing by mimicking human olfactory function and integrating colorimetric COF‐on‐MOF sensors with artificial intelligence (AI)‐assisted data analysis techniques. The Dye@Zeolitic Imidazolate Framework@Covalent Organic Framework (Dye@ZIF‐8@COF) sensor takes advantage of the highly porous structure of MOF core and hydrophobic nature of the COF shell, enabling highly sensitive colorimetric sensing of trace number of VOCs. The Dye@ZIF‐8@COF sensor exhibits exceptional sensitivity to VOCs at sub‐parts per million levels and demonstrates excellent humidity resistance (under 20–90% relative humidity), showing great promise for practical applications. Importantly, AI‐assisted information fusion and perceptual analysis greatly promote the accuracy of the VOCs sensing processes, enabling direct visualization and classification of seven stages of matcha drying processes with a superior accuracy of 95.74%. This work paves the way for the direct visualization of sensing processes of VOCs via the integration of advanced humidity‐resistant sensing materials and AI‐assisted data analyzing techniques.
Enantioselective Synthesis of α‐Hydroxy Allyl Ketones via BINAP‐CuH‐Catalyzed Hydroacylation
Authors: Maurya Sundaram , Navaneetha N. , Behera Prativa , Nanubolu Jagadeesh Babu , Roy Lisa , Chegondi Rambabu 
Published: January 2025

AbstractCatalytic hydrocupration of unsaturated carbon‐carbon bonds to generate organometallic nucleophiles has recently become an attractive alternative to conventional stoichiometric reagents in the stereoselective synthesis. Herein, we have developed an efficient and economical method to synthesize enantiopure α‐hydroxy allyl ketones via a copper hydride (CuH)‐catalyzed hydroacylation of alkoxyallenes, a significant advancement given the scarcity of reports on such scaffolds in the literature. DFT calculations reveal that this reaction proceeds through the nucleophilic attack of a kinetically favourable Z‐selective allyl‐copper intermediate on acid anhydrides via a six‐membered chair‐like transition state, stabilized by strongly attractive non‐covalent interactions that ultimately leads to high level of enantioselectivities using the simple BINAP ligand. This method successfully overcomes the challenges of over‐reduction of carbonyl functionality in the presence of CuH‐complex, olefin isomerization and the presence of a highly enolizable α‐stereocenter, which can lead to erosion in enantioselectivities, making our strategy highly desirable. The reaction exhibits a wide range of substrate scope including symmetrical as well as carbonic anhydrides with both aromatic, and aliphatic substitutions. In addition, α‐substituted acid anhydrides provide exclusive syn‐selective α,α′‐disubstituted allyl ketones in excellent enantiomeric ratios, where the nucleophilic allylation occurs on one of the carbonyls containing the matched α‐stereocenter, confirmed with mechanistic studies.
Minimising by Simulation‐Based Optimisation the Cycle Time for the Line Balancing Problem in Real‐World Environments
Authors: Moncayo–Martínez Luis A. , He Naihui , Arias–Nava Elias H. 
Published: January 2025

ABSTRACTIn the context of Industry 4.0, a production line must be flexible and adaptable to stochastic or real‐world environments. As a result, the assembly line balancing (ALB) problem involves managing uncertainty or stochasticity. Several methods have been proposed, including stochastic mathematical programming models and simulations. However, programming models can only incorporate a few sources of uncertainty that result in impractical or unfeasible solutions to implement due to overlooked complexities, while simulation is only used to test solutions from deterministic approaches or adjust parameters without maintaining their optimum value. The proposed methodology uses a deterministic mathematical model to minimize the cycle time, followed by the simulation to measure the impact of selected sources of uncertainty on the cycle time. Finally, the optimum value of the stochastic parameters is computed using simulation‐based optimization to maintain the average cycle time close to the deterministic one. A real‐life assembly line balancing problem for a motorcycle manufacturing company is solved to test the proposed methodology. The sources of uncertainty are the tasks' stochastic processing times, inter‐arrival time, the number of workers in each station, and the speed of the material handling system. Results show that the average cycle time is above 2.7% from the deterministic value computed by the programming model when the inter‐arrival time is set to 270 60 s; the processing times are allowed to increase or decrease by 3 s; the material handling system's speed is 1.5 m/s; and the number of workers in cells is between 4 and 6, with a speed of 2 m/s. The reader can download the source code and the simulation model to apply the methodology to other instances.
Deep Thinking in Reliability and Risk Analysis: An Overview of Nozer D. Singpurwalla's Work
Authors: Soyer Refik , Spizzichino Fabio 
Published: January 2025

ABSTRACTIn this article, an overview of Nozer Singpurwalla's work in reliability and risk analysis is provided. Rather than presenting a chronological review of his work, the emphasis is given to those areas of his research which better reflect Nozer's scientific personality.
Location of 7‐Aminoactinomycin D in Micellar Medium Depends on Ionic Nature of the Surfactant Head Group
Authors: Shit Debatri , Mandal Pabitra , Pramanik Smritimoy 
Published: January 2025

ABSTRACT7‐Aminoactinomycin D (7AAMD) is the fluorescent analogue of the anticancer drug actinomycin D (AMD). In order to overcome toxic side effects and enhanced bioavailability of 7AAMD, micellar drug carrier systems could be useful. We have used cationic (hexadecetyltrimethylammonium bromide [CTAB]), anionic (sodium dodecyl sulphate [SDS]) and non‐ionic (t‐octylphenoxypolyoxyethanol, Triton‐X100 [TX 100]) surfactants to prepare micelle. We have explored the mechanism of the interaction of 7AAMD with micelles using steady‐state and time‐resolved fluorescence spectroscopy. Our results revealed that the Stokes' shift values of 7AAMD were decreased in all three micellar medium compared to that in the absence of any micelle. Thus, 7AAMD is localized in less polar microenvironment of micelles than bulk water. In addition, from the time‐resolved fluorescence study of 7AAMD, we found that the relative contribution of the conformers of 7AAMD depended on the surfactant head group. Furthermore, acrylamide induced fluorescence quenching study shows differential accessibility of the quencher molecules towards 7AAMD depending on the ionic nature of the surfactant head group. In the presence of acrylamide, 7AAMD was expelled out from the non‐ionic TX 100 micelle but not in CTAB and SDS micelle. Thus, our results are valuable to design new drug delivery system for AMD‐like antitumor agents.
Alexidine and Pentamidine Fold Inside the Bowl‐shaped Cavity of p‐Sulfonato‐calix[4]arene
Authors: Kravets Kateryna , Kravets Mykola , Sashuk Volodymyr , Perret Florent , Maskani Widade , Albertini David , Lazar Adina‐N. , Zimnicka Magdalena M. , Danylyuk Oksana 
Published: January 2025

AbstractWe report on the U‐shaped folding of flexible guest molecules of medicinal interest upon their inclusion into macrocyclic cavity of p‐sulfonato‐calix[4]arene in aqueous media. Alexidine and pentamidine are FDA‐approved drug compounds currently rediscovered as potent membrane‐targeting antibiotic adjuvants helping restore antibiotic activity against multidrug resistant bacteria pathogens. We have adopted host‐guest and crystal engineering approach to study these drugs with a view of potential supramolecular formulations and/or crystal forms. We focus on the host‐guest conformational and structural behaviour of alexidine and pentamidine under macrocyclic confinement conditions benefitting from single crystal X‐ray diffraction analysis, self‐assembly studies in solution by NMR spectroscopy, dynamic light scattering and atomic force microscopy, and ion mobility mass spectrometry (IM–MS) analysis complemented by theoretical calculations. Our findings show that the simple bowl‐shaped host promotes conformational fixing and crystallization of these guest molecules of high conformational freedom that are otherwise challenging to crystallize. The IM–MS structural studies of p‐sulfonato‐calix[4]arene complexes with pentamidine and alexidine revealed significant guest reorganization in the solution/gas phase, compared to the binding modes observed in the crystal structures. Despite these changes, the host‐guest complexation remained consistent, with new interactions highlighting the increased role of electrostatic forces in the gas phase.
Force Degradation of Intermaxillary Latex Elastics: Comparative In Vitro and In Vivo Study
Authors: Ptáčková Lucie , Ličková Barbora , Urbanová Wanda , Sluka David , Portašíková Klaudia , Chamlarová Soňa , Voborná Iva , Dubovská Ivana 
Published: January 2025

ABSTRACTObjectiveThis study aimed to compare the force degradation of intermaxillary elastics (IE) in vitro and in vivo while stretching the IE to a precise diameter.Materials and MethodsIE 3/16″ medium Dentaurum from five different batches of packaging were analyzed. The in vivo study involved 10 volunteers, of which 100 IE were examined. To achieve three times the original diameter of the elastic, the distance between the upper canine and the lower dental arch was measured. Buttons were then placed in the mouth accordingly, and IE and passive aligners were inserted for five sessions of 48 h each. To investigate in vitro, 100 IE were placed in an incubator set at 37°C in a humid environment and stretched three times their diameter. The force of the elastics was measured in both investigations using a force meter at 0, 2, 8, 24, and 48 h.ResultsIn all patients except one, the three times diameter distance extended from the upper canine to the lower second premolar. The force degradation in vivo at 2, 8, 24, and 48 h was 20.58%, 26.78%, 34.81%, and 38.56% and in vitro was 16.38%, 22.83%, 28.32%, and 30.78%.ConclusionsThe amount of stretching of IE varies for each patient when using standard insertion points. The force of IE decreases exponentially, the force degradation in vivo being higher. The clinician must consider the force decrease when advising the patient of the time interval to change the elastics.
Histone methyltransferase KMT2A promotes pulmonary fibrogenesis via targeting pro‐fibrotic factor PU.1 in fibroblasts
Authors: Lyu Wenting , Wang Hui , Ji Tong , Liu Ling , Chen Haoran , Fan Li , Zhong Guanning , Wan Naihui , Chen Suwan , Chen Jingyu , Cai Hourong , Xu Hongyang , Wang Dongjin , Dai Jinghong 
Published: January 2025

AbstractBackgroundIdiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations to DNA sequence. KMT2A is a member of the SET family which catalyses H3K4 methylation.ResultsThrough microarray and single‐cell sequencing data, we discovered KMT2A‐positive fibroblasts were increased in IPF lung tissues. KMT2A level was increased in IPF and bleomycin‐induced pulmonary fibrosis mice lung tissues collected in our centre. Mice with AAV6‐induced KMT2A knockdown in fibroblast showed attenuated pulmonary fibrosis after bleomycin treatment. Bioinformation also revealed that transcription factor PU.1 was a target of KMT2A. We demonstrated that PU.1 levels were increased in IPF tissues, bleomycin‐induced mice lung tissues and primary fibrotic fibroblasts. KMT2A knockdown decreases PU.1 expression in vitro while KMT2A overexpression induces PU.1 activation. PU.1 fibroblast‐specific knockout mice showed attenuated lung fibrosis induced by bleomycin. Furthermore, we demonstrated KMT2A up‐regulated PU.1 in fibroblasts by catalysing H3K4me3 at the promoter of the PU.1 gene. The KMT2A transcription complex inhibitor mm102 treatment attenuated bleomycin‐induced pulmonary fibrosis.ConclusionThe current study indicated that histone modification participates in the pathogenesis of IPF and KMT2A may have the potential to be a therapeutic target of IPF treatment.Key points
KMT2A plays a role in pulmonary fibrogenesis.
KMT2A regulates PU.1 transcription in fibroblasts through H3K4me3 at promoter.
KMT2A inhibitor attenuates pulmonary fibrosis in mice.
Replacing native grazers with livestock influences arthropods to have implications for ecosystem functions and disease
Authors: Baidya Pronoy , Roy Shamik , Karapurkar Jalmesh , Bagchi Sumanta 
Published: January 2025

AbstractGrazing by large mammalian herbivores influences ecosystem structure and functions through its impacts on vegetation and soil, as well as by the influence on other animals such as arthropods. As livestock progressively replace native grazers around the world, it is pertinent to ask whether they have comparable influence over arthropods, or not. We use a replicated landscape‐level, long‐term grazer‐exclusion experiment (14 years) to address how ground‐dwelling arthropods respond to such a change in grazing regime where livestock replace native grazers in the cold deserts of the Trans‐Himalayan ecosystem of northern India. We analyze spatial and temporal variation in the abundance of 25,604 arthropods sampled using pitfall traps across 2765 trap‐days through the duration of the growing season spanning spring, summer, and autumn. These were from 88 operational taxonomic units covering six orders from 33 families (ants, wasps, bees, ticks and mites, spiders, grasshoppers, and beetles). We find that grazer assemblage—whether livestock or native herbivores—had a strong influence on both vegetation and arthropods. Partial redundancy analysis (RDA) showed that 53.6% of the spatial and temporal variation in arthropod communities could be explained by grazing and by grazer assemblage identity, alongside covariation with vegetation composition and soil variables. Structural equation models revealed that grazing and grazer assemblage identity have direct effects on arthropods, as well as indirect effects that are mediated through vegetation. Importantly, spiders (predators) were less abundant under livestock, whereas grasshoppers (leaf eaters) and ticks and mites (parasitic disease vectors) were more abundant, compared with native grazers. Reduction in spiders can fundamentally alter material and energy flow through the cascading effects of losing predators, and an abundance of grasshoppers may even contribute to vegetation degradation that is often associated with livestock. Parallelly, increases in ticks and mites lead to concerns over vector‐borne disease that require planned interventions to align animal husbandry with One Health. Thus, losing native grazers to livestock expansion can have wide‐ranging repercussions via arthropods. This may not only affect ecosystem structure and functions, but also offer challenges and opportunities to mitigate risks from vector‐borne disease.
Mammalian predator co‐occurrence affected by prey and habitat more than competitor presence at multiple time scales
Authors: Bassing Sarah B. , Ausband David E. , Mumma Matthew A. , Thompson Sarah , Hurley Mark A. , Falcy Matthew R. 
Published: January 2025

AbstractThe behavior and abundance of sympatric predators can be affected by a complex dominance hierarchy. The strength of antagonistic interactions in predator communities is difficult to study and remains poorly understood for many predator assemblages. Predators directly and indirectly influence the broader ecosystem, so identifying the relative importance of competition, prey, and habitat in shaping predator interactions has broad conservation and management implications. We investigated space use among five predator species (black bear [Ursus americanus], bobcat [Lynx rufus], coyote [Canis latrans], mountain lion [Puma concolor], and gray wolf [Canis lupus]) across three temporal scales in northern Idaho, USA. We used camera trap data to test whether potentially subordinate predators spatially avoided dominant predators and how prey availability influenced those relationships. We found few instances of subordinate predators spatially avoiding dominant predators and only at the finest temporal scale of our analyses. Instead, habitat features generally influenced predator space use patterns at coarser scales whereas prey and competitor presence influenced space use patterns at finer scales. Co‐occurrence was positively associated between coyotes and bobcats at coarser timescales and between mesopredators and apex predators at finer timescales. Bobcats and mountain lions temporarily delayed the use of sites recently visited by coyotes and black bears, respectively. And all predator species used sites sooner following the detection of a competitor in areas with higher relative abundances of prey (primarily white‐tailed deer [Odocoileus virginianus]). Our results suggest attraction to shared habitats and prey resources influenced space use in the predator community more than avoidance of competitors. We propose that the effects of interspecific interactions on predator distributions were most evident for mesopredators because their trophic position requires balancing risks and rewards associated with prey, apex predators, and other mesopredators. In addition, relatively high densities of a common prey source likely facilitated the spatial coexistence in this predator community. Our study demonstrates the value of simultaneously assessing multiple interspecific interactions across different spatiotemporal scales to discern relationships within the predator guild.