bluuebunny/crossref_metadata_2025_split huggingface dataset:
Religiöse Bildungsprozesse im Rahmen der „Kommunikation des Evangeliums“ – Einblicke in die Perspektiven der Subjekte
Authors: Pohl-Patalong Uta 
Published: November 2023

Zusammenfassung
Eines der Begleitprojekte der KMU VI widmet sich der Frage, wie der Prozess, der praktisch-theologisch gegenwärtig häufig als „Kommunikation des Evangeliums“ benannt wird, eigentlich von denjenigen erlebt wird, die an ihm teilnehmen, und welche Wirkung sie diesem zumessen. Das Projekt ist qualitativ ausgerichtet und wertet Gruppendiskussionen aus, die in verschiedenen kirchlichen Handlungsfeldern geführt wurden. In diesem Artikel erfolgt die Darstellung erster Ergebnisse mit dem Fokus auf Bildungsprozesse, die zu einer Stärkung des Subjekts, einem veränderten Verhältnis zur Welt, einem Zuwachs an Eigenständigkeit sowie zu einer kritischen Reflexion persönlicher Überzeugungen führen.
RNF144A promotes antiviral responses by modulating STING ubiquitination
Authors: Yang Bo , Pei Jinyong , Lu Chen , Wang Yi , Shen Mengyang , Qin Xiao , Huang Yulu , Yang Xi , Zhao Xin , Ma Shujun , Song Zhishan , Liang Yinming , Wang Hui , Wang Jie 
Published: November 2023

AbstractStimulator of interferon (IFN) genes (STING, also named MITA, ERIS, MPYS, or TMEM173) plays an essential role in DNA virus‐ or cytosolic DNA‐triggered innate immune responses. Here, we demonstrate that the RING‐in‐between RING (RBR) E3 ubiquitin ligase family member RING‐finger protein (RNF) 144A interacts with STING and promotes its K6‐linked ubiquitination at K236, thereby enhancing STING translocation from the ER to the Golgi and downstream signaling pathways. The K236R mutant of STING displays reduced activity in promoting innate immune signal transduction. Overexpression of RNF144A upregulates HSV‐1‐ or cytosolic DNA‐induced immune responses, while knockdown of RNF144A expression has the opposite effect. In addition, Rnf144a‐deficient cells exhibit impaired DNA virus‐ or cytosolic DNA‐triggered signaling, and RNF144A protects mice from DNA virus infection. In contrast, RNF144A does not affect RNA virus‐ or cytosolic RNA‐triggered innate immune responses. Taken together, our findings identify a new positive regulator of DNA virus‐ or cytosolic DNA‐triggered signaling pathways and a critical ubiquitination site important for fully functional STING during antiviral responses.
Le questionnaire Choux de la Revue canadienne des études sur l’alimentation
Authors: Sicotte Genevieve 
Published: November 2023

Variation sur le thème du célèbre questionnaire de Proust, le questionnaire des choux de la Revue canadienne des études sur l’alimentation vise à procurer une expérience savoureuse, et éventuellement surprenante, sous des apparences modestes. (Et oui, certaines questions se révèlent un peu plus croustillantes que les autres.) Les questions, simples en elles-mêmes, forment peu à peu, par leur combinaison, une joyeuse pyramide d’extravagance. La manière dont ce croquembouche composé est disposé et dégusté est toutefois laissée à la discrétion des personnes répondantes et du lectorat. Les personnes interrogées sont invitées à satisfaire leur gourmandise en répondant à autant de questions qu’elles le souhaitent. La toute dernière – Quelle question ajouteriez-vous à ce questionnaire? – incite chaque répondant à relever ce mélange d’une touche de son propre biome et de sa curiosité, rafraîchissant ainsi la culture de départ, qui restera nourrissante pour les futurs participants et participantes.
АНАЛІЗ НАПРУЖЕНО-ДЕФОРМОВАНОГО СТАНУ ТА МІЦНОСТІ ТРУБОПРОВОДУ З ВРАХУВАННЯМ НЕРЕГЛАМЕНТОВАНОГО СИЛОВОГО ВПЛИВУ ТА ЗАЛИШКОВИХ ДЕФОРМАЦІЙ
Authors: Бабуров В.В. , Гусев В.В. , Клименко Д.В. 
Published: November 2023

Викладена методика досліджень впливу нерегламентованого, непередбаченого у вихідних розрахунках, силового навантаження та залишкових деформацій на міцність попередньо пошкодженого трубопроводу з метою визначення можливості його подальшої експлуатації. Подані результати порівняльного аналізу скінченно-елементного розрахунку та експериментальних даних
NUMERICAL MODELING OF DYNAMIC DEFORMATION OF A THREE-LAYER RIBBED CYLINDRICAL SHELL UNDER AXISYMMETRIC IMPULSE LOADS
Authors: Каіров О.С. , Латанська Л.О. , Каіров В.О. 
Published: November 2023

The non-stationary vibrations of three-layer composite cylindrical shell under axisymmetric impulse loads have been researched. The mathematical model and method for calculating the dynamic deformation of the shell system under consideration is based on the geometrically nonlinear theory of Timoshenko’s type shells and ribs. The results of numerical analysis of the problem are presented.
A RESEARCH ON THE HAY YIELD AND QUALITY OF ALFALFA CULTIVARS WITH DIFFERENT FALL DORMANCY RATES UNDER MEDITERRANEAN CLIMATE CONDITIONS
Authors: DÖNMEZ Hasan Beytullah , HATİPOĞLU Rüştü 
Published: November 2023

This research was carried out as two separate trials established in two different years to determine the effects
of different seed ratios and harvest stages of different annual companion crop species on the hay yield and
botanical composition of a pasture mixture under Mediterranean climate conditions. The field trials were
established in a randomized complete block with a split-plot arrangement in three replications. The research
results showed that barley, annual ryegrass, and berseem clover can be utilized as companion crops in
artificial pasture systems. The inclusion of these companion crop species in the pasture mixture resulted in an
increase in forage yield and a significant decrease in weed infestation. While delaying the harvest stage of the
companion crop does not have a notable effect on the proportion of legumes and weeds in the total biomass, it
significantly enhances the dry forage yield and the proportion of grasses in the overall biomass of the mixture.
<i>In Silico</i> Computational Analysis of <i>Citrus aurantium</i> of <i>Thurunji manapagu</i> in Inhibiting the Receptor Target of Angiotensin-converting Enzyme Against <i>Uratha Pitha Vatham</i> (Hypertension)
Authors: Sudalaimani Radha , Thangapandiyan Swathi , Andi Mariappan , Udayar Sivakumar Shantiarappa , Ramasamy Meenakumari 
Published: November 2023

Citrus aurantium (Thurunji) is a tree cultivated in various parts of the world. The fruit pulp is used to make juices, marmalade and pickles. It is commonly used by tribes to treat digestive disorders, constipation, heaviness in the chest, prolapse of the uterus, anorexia, chest pain, cold, and cough. In the Siddha system of medicine, Citrus aurantium fruit pulp is used to prepare a formulation, syrup in consistency named Thurunji manapaagu indicated for diseases due to deranged pitha humor. According to the Siddha system of medicine Hypertension termed Uratha Pitha Vatham is an ailment that occurs due to an elevated pitham. Considering the facts an attempt of in silico docking study was done with the selected phytochemicals such as Linalool, Apigenin, Ichangin, Kaempferol, Luteolin, Limonin, Limonene, Myrcene, Diosmetin and Tangeretin of Citrus aurantium against Angiotensin Converting Enzyme (ACE) and the results are detailed in this article.
On graphs associated to topological spaces
Authors: Mohammed Salih Haval 
Published: November 2023

Let 𝑋 be a set and (𝑋,𝑇) be a topological space. A new type of graph on 𝑃(𝑋), namely the closure graph of 𝑇 is introduced. The closure graph denoted by <em>Γ<sup>c</sup></em> whose vertex set is 𝑃(𝑋) in which two distinct vertices 𝐴 and 𝐵 are adjacent if <em>A</em>'∩<em>B</em>' ⊆ (<em>A</em>∩<em>B</em>)'. In this paper, the closure graph is shown as a simple, connected graph with diameter at most two. Furthermore, the girth of the closure graph <em>Γ<sup>c</sup></em>of 𝑇 is three if 𝑋 contains more than one point. Also, several graph properties are studied.
Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures
Authors: Belardo Zoe E. , Talwar Divya , Blumberg Todd J. , Nelson Susan E. , Upasani Vidyadhar V. , Sankar Wudbhav N. , Shah Apurva S. 
Published: November 2023

Background:
Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report similar postoperative pain compared with children prescribed opioids following closed reduction and percutaneous pinning (CRPP) of supracondylar humeral fractures.

Methods:
Children who were 3 to 12 years of age and were undergoing CRPP for a closed supracondylar humeral fracture were prospectively enrolled in a multicenter, comparative study. Following a standardized dosing protocol, oxycodone, ibuprofen, and acetaminophen were prescribed at 2 hospitals (opioid cohort), and 2 other hospitals prescribed ibuprofen and acetaminophen alone (non-opioid cohort). The children’s medication use and the daily pain that they experienced (scored on the Wong-Baker FACES Scale) were recorded at postoperative days 1 to 7, 10, 14, and 21, using validated text-message protocols. Based on an a priori power analysis, at least 64 evaluable subjects were recruited per cohort.

Results:
A total of 157 patients were evaluated (81 [52%] in the opioid cohort and 76 [48%] in the non-opioid cohort). The median age at the time of the surgical procedure was 6.2 years, and 50% of the subjects were male. The mean postoperative pain scores were low overall (<4 of 10), and there were no significant differences in pain ratings between cohorts at any time point. No patient demographic or injury characteristics were correlated with increased pain or medication use. Notably, of the 81 patients in the opioid cohort, 28 (35%) took no oxycodone and 40 (49%) took 1 to 3 total doses across the postoperative period. Patients rarely took opioids after postoperative day 2. A single patient in the non-opioid cohort (1 [1%] of 76) received a rescue prescription of opioids after presenting to the emergency department with postoperative cast discomfort.

Conclusions:
Non-opioid analgesia following CRPP for pediatric supracondylar humeral fractures was equally effective as opioid analgesia. When oxycodone was prescribed, 84% of children took 0 to 3 total doses, and opioid use fell precipitously after postoperative day 2. To improve opioid stewardship, providers and institutions can consider discontinuing the routine prescription of opioids following this procedure.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Interpreted depositional conditions of balanced-fill lake basin strata incorporating vertebrate and invertebrate trace fossils, Triassic Santa Clara sub-basin, Cuyana rift basin, Argentina
Authors: Benavente Cecilia A. , Bohacs Kevin M. , Mancuso Adriana C. 
Published: November 2023

ABSTRACT
The Santa Clara Abajo and Santa Clara Arriba formations host a diverse assemblage of trace fossils that record a wide range of behaviors and a broad array of ecological niches during the Middle Triassic—a critical period in the evolution of continental fauna with the diversification of both synapsids (cynodont and dicynodont) and archosauromorphs (dinosaurs, pterosaurs, and crocodilians) that represent post-Permian faunal recovery. The Santa Clara formations are part of the continental infill of the Cuyana rift basin in Argentina and represent a lacustrine system with fluvial input and delta development. Sedimentological characteristics of these units as well as their stacking patterns characterize a “fluctuating profundal” facies association typical of a balanced-fill lake basin. The lacustrine and associated terrestrial environments preserve a rich record of invertebrate traces with 26 ichnogenera from ethological classes of fodichnia, domichnia, repichnia, pascichnia, and cubichnia occupying all continental tiers (subaerial and subaqueous, surficial, and/or very shallow, shallow, mid, and deeper) and ecological niches (epiterraphilic, terraphilic, hygrophilic, and hydrophilic). In association with invertebrate traces, two taphonomic modes of tetrapod footprints have been found: a moderate-fidelity mode and a high-fidelity mode. Physical sedimentary features, burrows, trails, and tracks, and their stratigraphic positions are integrated to interpret the main factors involved in footprint preservation in these subsettings. The most significant and variable preservational factor found is water-table fluctuation controlled by the paleohydrology of a balanced-fill lake system. These data show that in balanced-fill lake systems, diverse trace assemblages occur in the lake and associated subsettings such as delta plains and lake-margin settings, whereas trace fossils can be totally absent in coeval lake-center strata, particularly if anoxic lake-bottom conditions occur, as probably occurred in the meromictic Santa Clara lake system.
Multi-objective optimization of laser welding parameters for Steel/Al based on Kriging-MSSA
Authors: Zhu Zhiwei , Guo Yonghuan , Zhang Xin-ran , Lu Xiang-ning , Hua Jun-yi 
Published: November 2023

Abstract
In the context of automotive lightweighting strategy, steel/aluminum hybrid structures are widely used in the automotive industry. To address the reliability of steel/aluminum dissimilar metal joints, this study conducted steel/aluminum dissimilar metal laser welding tests by Taguchi's design of experiments method and obtained relevant data. Based on the test results, a Kriging model with laser power, welding speed and defocusing amount as inputs, and base material deformation and welded joint tensile strength as outputs was established. In this paper, with the amount of deformation of base material and tensile strength of welded joints after welding as the optimization objectives, the optimization analysis is carried out by combining the Kriging model and the multi-objective bottled sea-sheath swarm optimization algorithm (MSSA). The results show that under the conditions of laser power of 450.47W, welding speed of 11.88mm/s, and defocusing amount of 5.34mm, the optimization objective reaches the optimal level, the base material warpage deformation is reduced by 22.33% compared with the pre-optimization, and the tensile strength of the welded joints is improved by 18.01%.
Molecular Characteristics and Prognostic Role of EPHA2 in Human Tumors via Pan-cancer Analysis
Authors: Wang Guoqiang , Liang Zhipan , Guo Fen , Zhang Luyao 
Published: November 2023

Abstract
Background: The tyrosine kinase ephrin type-A receptor 2（EPHA2）is remarkably elevated expressed in various tumors and plays a crucial role in cancer tumorigenesis and progression, while pan-cancer analyses (PCA) are currently lacking. This study was designed to analyze the expression status and prognostic significance of EPHA2 in pan-cancer.
Methods: By mining The Cancer Genome Atlas (TCGA) data, we performed a comprehensive and systematic characterization of EPHA2 across more than 10,000 samples of 33 types of cancer.
Results: EPHA2 expressions were substantially different in most of the normal control and tumor tissues and considerably associated with the prognosis of tumor patients. In addition, the missense mutation is more prevalent in EPHA2 genetic modification in malignancies. Moreover, a notable association has been developed between EPHA2 expressions and cancer-associated fibroblasts (CAFs) in most TCGA cancers. Furthermore, Functional enrichment analysis showed that the biological role of EPHA2 in tumors is mainly involved in some noticeably pro-oncogenic pathways, such as the Ras signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway, MAPK signaling pathway, etc.
Conclusions: This study provides the first PCA with the extensive role of EPHA2 in various tumors, and EPHA2 is potentially involved in many cancer types and can be developed as candidates for cancer diagnosis, prognosis, and therapeutic biomarkers.
Study on the oxidized gas production characteristics and spontaneous combustion tendency of pre-oxidized water-soaked coal in lean-oxygen environments
Authors: Niu Hui-yong , Yang Xi , Sun Qing-qing , Sun Siwei , Wang Haiyan , Yu Xiaodong 
Published: November 2023

Abstract
In order to study the oxidation characteristics and spontaneous combustion (SC) tendency of pre-oxidized long-term water-soaked coal under different oxygen concentrations, raw long-flame coal (RC), water-soaked 200-day coal (S200), pre-oxidized water-soaked coal at 200 ℃ (O200S200), and pre-oxidized water-soaked coal at 300 ℃ (O300S200) coals were used for the study. The coal spontaneous combustion(SC) program heating test system was adopted to conduct experimental analyses at 21%, 15%, 10%, 5%, 3% oxygen concentration(OC) for experimental analysis. The results show that pre-oxidation water-soaked treatment(PWT) promotes the coal-oxygen complex reaction and increases the rate of coal oxygen consumption(OCR) and the rate of carbon and oxygen compounds production. The rate of CO and CO2 production of the water-soaked(WS) coal increased by 0.329 mol·(cm3·s)−1 and 0.922 mol·(cm3·s)−1, respectively, compared with that of the original coal sample. PWT reduces the activation energy of coal in the low-temperature oxidation stage (the maximum difference can be up to 110.99 KJ/mol) and enhances the oxidizing and heat-releasing capacity. There is a large amount of water in the WS coal, and its cross-point temperature and SC propensity index increased. There was a synergistic effect between the pre-oxidation(PO) and WS treatment, and the lowest comprehensive determination index of the SC propensity of coal in O200S200 samples was 831.92 which was 4.72 lower than that of RC samples, presenting a more SC tendency. Low oxygen concentration has inhibitory effect on the oxidation characteristic parameters of coal, and the apparent activation energy of low-temperature oxidation stage of pre-oxidized water-soaked coal(PWC) increased to 206.418 KJ/mol at 3% oxygen concentration. Both WS and PWT can improve the oxidation activity of coal, and the S200 samples have the most carbon oxides production in the anoxic environment, and the SC risk of the O200S200 samples is the highest. The lower the oxygen concentration of the anoxic environment, the lower the risk of SC of the coal samples. The oxidation characteristics and SC tendency of the PWC under different oxygen concentrations revealed in the study can provide theoretical guidance for the identification and prevention of SC disasters in coal seams with shallow burial and close spacing.
Application of machine learning models to identify serological predictors of COVID-19 severity and outcomes
Authors: Klein Sabra , Dhakal Santosh , Yin Anna , Escarra-Senmarti Marta , Demko Zoe , Pisanic Nora , Johnston Trevor , Trejo-Zambrano Maria , Kruczynski Kate , Lee John , Hardick Justin , Shea Patrick , Shapiro Janna , Park Han-Sol , Parish Maclaine , Caputo Christopher , Ganesan Abhinaya , Mullapudi Sarika , Gould Stephen , Betenbaugh Michael , Pekosz Andrew , Heaney Christopher D , Antar Annukka , Manabe Yukari , Cox Andrea , Karaba Andrew , Andrade Felipe , Zeger Scott 
Published: November 2023

Abstract

Critically ill people with COVID-19 have greater antibody titers than those with mild to moderate illness, but their association with recovery or death from COVID-19 has not been characterized. In 178 COVID-19 patients, 73 non-hospitalized and 105 hospitalized patients, mucosal swabs and plasma samples were collected at hospital enrollment and up to 3 months post-enrollment (MPE) to measure virus RNA, cytokines/chemokines, binding antibodies, ACE2 binding inhibition, and Fc effector antibody responses against SARS-CoV-2. The association of demographic variables and >20 serological antibody measures with intubation or death due to COVID-19 was determined using machine learning algorithms. Predictive models revealed that IgG binding and ACE2 binding inhibition responses at 1 MPE were positively and C1q complement activity at enrollment was negatively associated with an increased probability of intubation or death from COVID-19 within 3 MPE. Serological antibody measures were more predictive than demographic variables of intubation or death among COVID-19 patients.
Event-triggered adaptive fault estimation and fault-tolerant control for strict-feedback nonlinear systems with full state constraints
Authors: Liu Ming-Rui , Wu Li-Bing , Wu Meng , Ma Wen-Chao 
Published: November 2023

Abstract

This paper addresses the problem of eventbased adaptive fault estimation (FE) and fault-tolerant control (FTC) for a class of strict-feedback nonlinear systems with full state constraints. The unknown fault and the to-be-tested states of the system are estimated by an innovative adaptive fault observer based on a modified intermediate variable update law with fault switching function. In addition, an event-triggered mechanism and adaptive fault-tolerant controller co-design scheme is proposed according to backstepping algorithm and constrained technique, which not only eliminates the effect of fault presence but also leads to a significant reduction of communication resources. Through theoretical analysis, the constructed controller ensures that all signals within the system are ultimately bounded, and the state errors converge to the desired neighborhoods. Finally, the effectiveness of the method is illustrated by a simulation example of a single-link robot system.
Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning
Authors: Dong Qichang , Wang Shaohua , Miao Ying , Luo Heng , Weng Zuquan , Yu Lun 
Published: November 2023

Abstract
The increasing prevalence of antibiotic resistance in Cutibacterium acnes (C.acnes) requires the search for alternative therapeutic strategies. Antimicrobial peptides (AMPs) offer a promising avenue for the development of new treatments targeting C.acnes. In this study, to design peptides with the specific inhibitory activity against C.acnes, we employed a deep learning pipeline with generators and classifiers, using transfer learning and pretrained protein embeddings, trained on publicly available data. To enhance the training data specific to C.acnes inhibition, we constructed a phylogenetic tree. A panel of 42 novel generated linear peptides was then synthesized and experimentally evaluated for their antimicrobial selectivity and activity. Five of them demonstrated their high potency and selectivity against C.acnes with MIC of 2-4 µg/mL. Our findings highlight the potential of these designed peptides as promising candidates for anti-acne therapeutics and demonstrate the power of computational approaches for the rational design of targeted antimicrobial peptides.
Efficient Wideband Transmission and Direction-Finding Implementation Scheme in Noisy Rician Channels for Wearable Monitoring
Authors: Aldelemy Ahmad , Oguntala George , Gadhafi Rida , Amar Ahmed , Shuaieb Wafa S. , Abd-Alhameed Raed 
Published: November 2023

Abstract
This paper proposes a new technique for wideband transmission and direction-finding using orthogonal frequency division multiplexing (OFDM) for wearable devices in noisy Rician channels. The technique uses a coded OFDM signal combined with a pseudo-random permutation and a Walsh sequence to mitigate inter-carrier interference, peak-to-average power ratio, and frequency offset. The technique also inserts a pilot symbol into each OFDM block and uses it for frequency offset estimation, channel estimation, message detection, and angle of arrival estimation. The technique employs a delay discrimination algorithm to extract the first arriving impulse from each antenna channel and then applies a direction-finding algorithm to estimate the angle of arrival. The technique is evaluated through rigorous simulations using MATLAB. It shows superior performance and reliability compared to existing methods in terms of signal-to-noise ratio, bit error rate, and angle error.