bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2
Authors: Shimizu Masayuki , Yoshimatsu Gumpei , Morita Yuichi , Tanaka Tomoko , Sakata Naoaki , Tagashira Hideaki , Wada Hideichi , Kodama Shohta 
Published: November 2023

AbstractCritical limb ischemia (CLI) is caused by severe arterial blockage with reduction of blood flow. The aim of this study was to determine whether therapeutic angiogenesis using cellular communication network factor 2 (CCN2) would be useful for treating CLI in an animal model. Recombinant CCN2 was administered intramuscularly to male C57BL/6J mice with hind limb ischemia. The therapeutic effect was evaluated by monitoring blood flow in the ischemic hind limb. In an in vivo assay, CCN2 restored blood flow in the ischemic hind limb by promoting both angiogenesis and lymphangiogenesis. VEGF-A and VEGF-C expression levels increased in the ischemic limb after treatment with CCN2. In an in vitro assay, CCN2 promoted proliferation of vascular and lymphatic endothelial cells, and it upregulated expression of Tgfb1 followed by expression of Vegfc and Vegfr3 in lymphatic endothelial cells under hypoxia. Suppression of Tgfb1 did not affect the activity of CCN2, activation of the TGF-β/SMAD signaling pathway, or expression of Vegfr3 in lymphatic endothelial cells. In summary, treatment using recombinant CCN2 could be a promising therapeutic strategy for CLI.
The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study
Authors: Park Bong Soo , Choi Byeongo , Heo Chang Min , Lee Yoo Jin , Park Sihyung , Kim Yang Wook , Ko Junghae , Lee Dong Ah , Park Kang Min 
Published: November 2023

AbstractThis study aimed to determine whether white matter tracts correlate with kidney function using correlation tractography, and to investigate the effects of dialysis on white matter tracts in patients with end-stage renal disease (ESRD) using differential tractography. Ten patients with ESRD, who had a glomerular filtration rate of < 15 mL/min/1.73 m2, were enrolled in this prospective study. Diffusion tensor imaging (DTI) was performed both before and after dialysis. We discovered that white matter tracts correlated with the estimated glomerular filtration rate based on pre- and post-dialysis DTI using correlation tractography and investigated the differences in the white matter tracts between pre- and post-dialysis DTI in patients with ESRD using differential tractography. Correlation tractography revealed no quantitative anisotropy of the white matter tracts that correlated with the estimated glomerular filtration rate in pre- and post-dialysis patients with ESRD. Differential tractography revealed significant differences in several white matter tracts, particularly the cingulum, thalamic radiation, corpus callosum, and superior longitudinal fasciculus, between pre- and post-dialysis DTI, which revealed increased diffusion density after dialysis. We demonstrated the significant effects of dialysis on several white matter tracts in patients with ESRD using differential tractography, which showed increased diffusion density after dialysis. In this study, we confirmed the effects of dialysis on brain structure, especially white matter tracts.
Microfluidic investigation of pore-size dependency of barite nucleation
Authors: Poonoosamy Jenna , Obaied Abdulmonem , Deissmann Guido , Prasianakis Nikolaos I. , Kindelmann Moritz , Wollenhaupt Bastian , Bosbach Dirk , Curti Enzo 
Published: November 2023

AbstractThe understanding and prediction of mineral precipitation processes in porous media are relevant for various energy-related subsurface applications. While it is well known that thermodynamic effects can inhibit crystallization in pores with sizes <0.1 µm, the retarded observation of mineral precipitation as function of pore size is less explored. Using barite as an example and based on a series of microfluidic experiments with well-defined pore sizes and shapes, we show that retardation of observation of barite crystallite can already start in pores of 1 µm size, with the probability of nucleation scaling with the pore volume. In general, it can be expected that mineralization occurs preferentially in larger pores in rock matrices, but other parameters such as the exchange of the fluids with respect to reaction time, as well as shape, roughness, and surface functional properties of the pores may affect the crystallization process which can reverse this trend.
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Authors: Kovatcheva Marta , Melendez Elena , Chondronasiou Dafni , Pietrocola Federico , Bernad Raquel , Caballe Adrià , Junza Alexandra , Capellades Jordi , Holguín-Horcajo Adrián , Prats Neus , Durand Sylvere , Rovira Meritxell , Yanes Oscar , Stephan-Otto Attolini Camille , Kroemer Guido , Serrano Manuel 
Published: November 2023

AbstractTransient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency of reprogramming both in mice and in cultured cells, the latter indicating a cell-intrinsic effect. We show that the epigenetic mark H3K36me3, which prevents illegitimate initiation of transcription outside promoters (cryptic transcription), is sensitive to vitamin B12 levels, providing evidence for a link between B12 levels, H3K36 methylation, transcriptional fidelity and efficient reprogramming. Vitamin B12 supplementation also accelerates tissue repair in a model of ulcerative colitis. We conclude that vitamin B12, through its key role in one-carbon metabolism and epigenetic dynamics, improves the efficiency of in vivo reprogramming and tissue repair.
An Absorbance Peak Template for Clinical Assessment of Sound Conduction in Newborn Ears
Authors: AlMakadma Hammam A. , Reed Beth F. , Sanford Chris A. 
Published: November 2023

Purpose:
Power absorbance measures recorded over a wide range of frequencies allow for clinical inferences about the outer/middle ears' acoustic mechanics. A frequency-dependent feature in the newborn wideband absorbance response, the prominent mid-frequency absorbance peak, has been linked to middle-ear resonance. However, current normative methods were not designed to assess subtle changes in such features. This work aims to develop and validate an absorbance peak template (APT) for assessment of absorbance peaks in newborns. Additional objectives are to compare test performance of absorbance peaks and APTs to existing normative methods, to demonstrate APT-based methods for categorization of abnormal absorbance peaks, and to describe absorbance peak test–retest variability.

Method:
Peak absorbance and peak frequency were analyzed in a training data set (490 measurements in 84 newborn ears who passed transient evoked otoacoustic emissions [TEOAEs] screenings), and an APT was developed by computing normal limits on these two absorbance peak variables. Split-set analysis evaluated the reproducibility of APT, and test–retest analysis was performed. Test performance analysis, conveyed by area under the receiver operating characteristic curve (AROC) and 95% confidence intervals (CIs), compared absorbance peak variables to absorbance area indices (AAIs) in a validation data set (359 ears that passed distortion-product OAE [DPOAE] screening and 64 ears that failed). APT-based assessment paradigms for normal and abnormal ears were compared to the common absorbance normative range paradigm.

Results:
Split-set analysis demonstrated a good reproducibility of APT, and test–retest of absorbance peak variables showed that they were stable measures for clinical assessment. Test performance of peak absorbance (AROC = 0.83; 95% CI [0.77, 0.88]) was comparable to the top-performing AAI variables (AROC = 0.85; 95% CI [0.80, 0.90]). APT-based assessment categorized measurements based on their peak absorbance and peak frequency and enhanced the detection of subtle frequency changes that were missed by the normative range method.

Conclusion:
Analysis of absorbance peaks guided by APT has the potential to simplify and improve assessments of sound conduction pathways in newborn ears and can be used together with or in-place of current methods for analysis of wideband absorbance data.
Condition monitoring of permanent magnet AC machines for all‐electric transportation systems: State of the art
Authors: Usman Adil , Rajpurohit Bharat Singh 
Published: November 2023

AbstractThe current state of the art on emerging and efficient techniques for condition monitoring of permanent magnet (PM) alternating‐current (AC) machines deployed in electric vehicle (EV) applications is presented. The discussion includes the most common and specific types of faults in PM motors, such as rotor demagnetisation and stator inter‐turn faults, respectively. Fault indicators, such as voltage (vs) and current (is) signals and machine signatures based on motor back electromotive force (EMF) (EB) and magnetic flux (ϕ), are taken into account as a measuring quantity in diagnosing motor faults. Other signatures, including thermal analysis, acoustic noise, and vibrations, are also illustrated as some of the emerging techniques in estimating the performance of EV motors while under operations. In addition, various fault modelling methods, condition monitoring techniques, and comprehensive approaches applied in diagnosing the effect of machine faults during its incipient stages are illustrated. Since most of the fault diagnostic techniques discussed here include only machine‐based quantities as fault indices/indicators, the provided solutions are therefore found to be more reliable and accurate for diagnosing the motor faults. This comprehensive review study is inclusive of the existing fault diagnostic techniques, which are currently employed in industrial and commercial practices, in addition to the new methodologies proposed by the authors. All the given condition monitoring schemes therefore seem significantly vital in estimating the state of health of PM AC machines while under operation in all‐electric transportation systems.
Direct current power system stabilizers for HVDC grids: Current status
Authors: Azizi Neda , Moradi Hassan , Rouzbehi Kumars , Mehrizi‐Sani Ali 
Published: November 2023

AbstractA power system stabilizer (PSS) is a control system integrated into the control structure of specific generation units within AC grids. It monitors current, voltage, and machine shaft speed. Analysing these variables, the PSS generates appropriate control signals to the voltage regulator unit, aiming to damp system oscillations. With the advancement of high‐voltage direct current (HVDC) overlaid high‐voltage alternative current (HVAC) grids, it is anticipated that direct current power system stabilizers (DC‐PSS) will be developed to perform a similar role as their AC counterparts. DC‐PSS will be responsible for monitoring and controlling DC voltage levels, ensuring stable operations. This paper focuses on DC‐PSS in HVDC grids, designed to ensure stable operation and mitigate voltage fluctuations. Unlike conventional AC power systems, HVDC includes only DC voltage and power. The input signal for DC‐PSS is the variations in DC voltage, and the output signal is proportional to the power changes at the specific bus where the DC‐PSS is installed, aiming to minimize DC voltage oscillations. These characteristics pose significant challenges in DC‐PSS. The paper addresses the challenges and highlights issues such as inertia and low‐frequency oscillations associated with DC‐PSS. Various control methods are presented and a comparison is made among these methods.
AI safety of film capacitors
Authors: Zhang Yong‐Xin , Chen Fang‐Yi , Liu Di‐Fan , Wang Jian‐Xiao , Feng Qi‐Kun , Jiang Hai‐Yang , Wang Xin‐Jie , Zhao Hong‐Bo , Zhong Shao‐Long , Shah Faisal Mehmood , Dang Zhi‐Min 
Published: November 2023

AbstractWith a large number of film capacitors being deployed in critical locations in electrical and electronic systems, artificial intelligence (AI) technology is also expected to address the problems encountered in this process. According to our findings, AI applications can cover the entire lifecycle of film capacitors. However, the AI safety hazards in these applications have not received the attention they deserve. To meet this, the authors argue, with specific examples, risks that flawed, erratic, and unethical AI can introduce in the design, operation, and evaluation of film capacitors. Human‐AI common impact and more multi‐dimensional evaluation for AI are proposed to better cope with unknown, ambiguity, and known risks brought from AI in film capacitors now and in the future.
Nachhaltige StadtGesundheit als Denk- und
Handlungsansatz
Authors: Fehr Rainer , Hornberg Claudia 
Published: November 2023

ZusammenfassungDas Themen- und Arbeitsfeld Urban Health, also die Anwendung von Public Health
für die Menschen in der Stadt, ist sowohl auf wissenschaftliche
Erkenntnis als auch auf Handlungspraxis ausgerichtet. Im internationalen Raum
existiert dafür eine wissenschaftliche Infrastruktur. Trotz gemeinsamer
Wurzeln von Public Health und Stadtplanung auch in Deutschland trat hier die
Verbindung dieser Arbeitsfelder für lange Zeit nur wenig in Erscheinung.
Gesetzliche Vorgaben zur Mitwirkung des Öffentlichen Gesundheitsdienstes
an (Stadt-)Planungsprozessen entwickelten bisher wenig Durchschlagskraft. So
entstand die Absicht, Anschluss an die internationalen Urban
Health-Entwicklungen zu finden, um das Thema sichtbarer zu machen, den
fachlichen Austausch zu unterstützen und Impulse für Forschung
und Praxis zu geben. Um die engen Verbindungen zwischen menschlicher Gesundheit,
ökologischer Stabilität und sozialer Gerechtigkeit zum Ausdruck
zu bringen, wurde der Ansatz als Nachhaltige StadtGesundheit konzipiert. In
diesem Sinne startete 2011 das Programm „Stadt der Zukunft –
Gesunde, nachhaltige Metropolen“. Dieser Beitrag charakterisiert den
Grundansatz als integrierend und anschaulich, beschreibt die Leitprinzipien
(„Blickfelderweiterung“ als erkenntnisleitendes und
„Brückenbau“ als handlungsleitendes Prinzip) und
umreißt die Ausgestaltung. Das Spektrum der Themenfelder reicht von
medizinischer und pflegerischer Versorgung über
„klassische“ Prävention und Gesundheitsförderung
hin zu „Gesundheit in allen Politikfeldern“. Innerhalb dieses
Ansatzes lassen sich einerseits „kleinere“ Aufgaben verfolgen,
bspw. ein Überblick über lokale Gesundheitsaktionen und
-akteure; eine Vernetzungsförderung; oder das Aufbewahren bedeutsamer
Entwicklungen im kollektiven Gedächtnis. Zum anderen geht es um
Beiträge zur Lösung „großer“ Aufgaben,
bspw. die Ableitung von Folgerungen aus der Corona-Lernerfahrung; eine
konsequentere Umsetzung von Health in All Policies; oder Transformationsschritte
in Richtung einer ökologisch nachhaltigen Gesellschaftsentwicklung. Als
Leitmotive kommen Rechtsnormen, Öffentlicher Gesundheitsdienst,
Gesundheitsberichterstattung und Stadtplanung zur Sprache. Der Beitrag
umreißt auch die Genese der Positionspapiere in diesem Supplementband
und schließt mit einem Ausblick.
Stadtplanung, urbane Initiativen und Gesundheit
Authors: Köckler Heike , Knieling Jörg , Fehr Rainer 
Published: November 2023

ZusammenfassungStadtplanung und Public Health sind zentrale Handlungsfelder, um Stadtentwicklung
aus einer gesundheitlichen Perspektive zu betrachten. In beiden Handlungsfeldern
spielen Politik und Verwaltung ebenso wie urbane Initiativen eine gestaltende
Rolle. Das Handeln richtet sich auf die gemeinsamen übergeordneten
Themenlinien Zukunftsfähigkeit, soziale Gerechtigkeit und umweltbezogene
Gerechtigkeit aus. Diese Gemeinsamkeiten spiegeln sich in unterschiedlichen
Memoranden wider. Trotz dieser gemeinsamen Basis von Stadtplanung und
Gesundheitswesen gibt es Spannungsfelder, die unter anderem in verschiedenen
rechtlichen Rahmenbedingungen und Handlungslogiken begründet liegen. Vor
diesem Hintergrund werden Empfehlungen für die Wissenschaft, die
Förderlandschaft, die Praxis sowie die Aus- und Weiterbildung
formuliert.
Diagnostic approach to splenic lesions
Authors: Krähling Hermann , Seidensticker Max , Heindel Walter L. , Gerwing Mirjam 
Published: November 2023

Background Splenic lesions are rare and mostly incidental findings on cross-sectional imaging. Most lesions are of benign nature and can be correctly identified based on imaging characteristics. Further, invasive evaluation is only necessary in cases of splenic lesions with uncertain or potentially malignant etiology.
Method While in most cases a correct diagnosis can be made from computed tomography (CT), (additional) magnetic resonance imaging (MRI) can aid in the identification of lesions. As these lesions are rare, only a few of the differential diagnoses are regularly diagnosed in the clinical routine.
Result and Conclusion This review presents the differential diagnoses of splenic lesions, including imaging characteristics and a flowchart to determine the right diagnosis. In conjunction with laboratory results and clinical symptoms, histological workup is necessary only in a few cases, especially in incidental findings. In these cases, image-guided biopsies should be preferred over splenectomy, if possible.
Key Points
Citation Format
Prediction Models for Successful External Cephalic Version: An Updated Systematic Review
Authors: Yerrabelli Rahul Sai , Lee Claire , Palsgaard Peggy K. , Lauinger Alexa R. , Abdelsalam Omer , Jennings Valerie 
Published: November 2023

Objective To review the decision aids currently available or being developed to predict a patient's odds that their external cephalic version (ECV) will be successful.
Study Design We searched PubMed/MEDLINE, Cochrane Central, and ClinicalTrials.gov from 2015 to 2022. Articles from a pre-2015 systematic review were also included. We selected English-language articles describing or evaluating models (prediction rules) designed to predict an outcome of ECV for an individual patient. Acceptable model outcomes included cephalic presentation after the ECV attempt and whether the ECV ultimately resulted in a vaginal delivery. Two authors independently performed article selection following PRISMA 2020 guidelines. Since 2015, 380 unique records underwent title and abstract screening, and 49 reports underwent full-text review. Ultimately, 17 new articles and 8 from the prior review were included. Of the 25 articles, 22 proposed one to two models each for a total of 25 models, while the remaining 3 articles validated prior models without proposing new ones.
Results Of the 17 new articles, 10 were low, 6 moderate, and 1 high risk of bias. Almost all articles were from Europe (11/25) or Asia (10/25); only one study in the last 20 years was from the United States. The models found had diverse presentations including score charts, decision trees (flowcharts), and equations. The majority (13/25) had no form of validation and only 5/25 reached external validation. Only the Newman–Peacock model (United States, 1993) was repeatedly externally validated (Pakistan, 2012 and Portugal, 2018). Most models (14/25) were published in the last 5 years. In general, newer models were designed more robustly, used larger sample sizes, and were more mathematically rigorous. Thus, although they await further validation, there is great potential for these models to be more predictive than the Newman–Peacock model.
Conclusion Only the Newman–Peacock model is ready for regular clinical use. Many newer models are promising but require further validation.
Key Points
Weight Loss, Stability, and Low Weight Gain during Pregnancy among Individuals with Obesity: Associations with Adverse Perinatal Outcomes: An Observational Study
Authors: Widen Elizabeth M. , Nichols Amy R. , Harper Lorie , Cahill Alison , Davis Jaimie N. , Foster Saralyn F. , Rickman Rachel R. , Xu Fei , Hedderson Monique M. 
Published: November 2023

Objective The safety of weight loss and low weight gain during pregnancy remains unclear. To determine how different patterns of gestational weight gain (GWG), including weight loss, stability, and low GWG relate to perinatal outcomes by prepregnancy obesity class.
Study Design The study population included 29,408 singleton livebirths among pregnant people with obesity from Kaiser Permanente Northern California (2008–2013). Clinically measured GWG was grouped into meaningful categories (Adequate: reference, met 2009 National Academy of Medicine [NAM] Guidelines [5–9.1 kg], Excessive [>9.1 kg], Low [1–4.9 kg], Stable [±1 kg], Weight Loss [>1 kg]) or GWG Z-score quintiles. Modified Poisson regression was used to estimate risk of adverse outcomes, stratified by obesity class. Electronic health record data were used to define outcomes, including cesarean delivery, preterm birth, admission to the neonatal intensive care unit, small- and large-for-gestational age infants.
Results Prevalence of weight stability and weight loss was 3.8 and 3.4%, respectively. Compared with those who gained within NAM, increased risk of small-for-gestational age was observed among those with weight loss among obesity class I (Risk Ratio (RR): 1.57, 95% confidence interval [CI]: 1.12, 2.19), obesity class II (RR: 2.18, 95% CI: 1.52, 3.13), and obesity class III (RR: 1.72, 95% CI: 1.21, 2.45). Weight loss was associated with a decreased risk of cesarean delivery among obesity class III, compared with NAM.
Conclusion Weight loss during pregnancy is associated with increased risk of small-for-gestational age among all obesity classes, but not other adverse perinatal outcomes and may reduce risk of cesarean delivery. Low weight gain and weight stability are not associated with risk of adverse outcomes among those with class III obesity. GWG guidelines may need to vary by obesity class.
Key Points
Applying Lessons Learned from Developing Exon Skipping for Duchenne to Developing Individualized Exon Skipping Therapy for Patients with Neurodegenerative Diseases
Authors: Aartsma-Rus Annemieke 
Published: November 2023

AbstractAntisense oligonucleotides (ASOs) are short, modified pieces of DNA that are chemically modified. They can be used to induce exon skipping and treat Duchenne muscular dystrophy (DMD) patients by interfering with the splicing process so mutated dystrophin transcripts become readable allowing production of partially functional dystrophin proteins, rather than nonfunctional dystrophins. After over 2 decades of research, 4 ASOs are FDA approved for DMD, but clinical effects are suboptimal due to limited delivery to skeletal muscle. At the same time, ASOs for brain diseases result in much more functional impact, because local delivery allows higher exposure to the target tissue at a low dose and infrequent treatment regimen. This has opened the way to develop ASOs in an individualized setting, as was exemplified by the development of Milasen to treat a patient with CLN7 Batten disease.In this perspective paper I will share my personal journey as one of the pioneers of ASO-mediated exon skipping development for DMD, currently applying expertise gained and lessons learned along the way to develop exon skipping ASOs for eligible patients with genetic brain diseases in a national and international setting.1	Duchenne and Antisense-Mediated Exon Skipping2	Opportunities for Treating Central Nervous System Diseases and Developing Individualized ASOs for Central Nervous System Diseases3	Collaborative Spirit to Develop Individualized Treatments Globally4	Global Implementation5	Concluding Remarks