bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of ABCDE approach knowledge among residents and interns in multiple Egyptian hospitals, a cross-sectional study
Authors: Rakab Mohamed Saad , Zaid Ahmed B. , Hamadein Malak Abbas , Hamadein Salma Abbas , Ashour Mahmoud Abd Elgawad , El-Shamia Alaa Samir , Mostafa Dina Ayman , Rateb Rahma Mogahed , Elashry Marwa Abdelrahman , El-Badawy Mennat-Allah Mostafa , Shaheen Rehab Shaheen Bahram 
Published: January 2025

Abstract

Background
The Airway, Breathing, Circulation, Disability, and Exposure (ABCDE) approach is crucial in emergency care, but there may be variability in adherence among healthcare professionals. Inconsistent application of this approach may lead to variations in patient care quality and outcomes. Identifying the factors influencing adherence can help improve training to ensure more effective application across emergency settings. This study explores the theoretical knowledge of the ABCDE approach among Egyptian resident doctors and medical interns.

Methods
An online survey was conducted in Egypt targeting resident doctors and medical interns. Statistical analyses were performed using SPSS 26 and Excel, descriptive statistics and association tests were used to measure the relationship between knowledge and demographic factors.

Results
The study included 422 medical residents and interns, with most in university hospitals. The average knowledge score of 59.1% exposed specific gaps in understanding, emphasizing deficiencies in 12 questions answered by less than 50%. Notably, 49.5% acquired ABCDE knowledge from medical school, while 28.2% had ALS/BLS courses. Encouragingly, 91.2% expressed willingness for life support training. Statistical analyses unveiled significant associations between knowledge scores and both medical practice settings and sources of ABCDE knowledge. Surgeons exhibited the lowest knowledge scores among participants, emphasizing the need for tailored interventions across specialties.

Conclusion
This study addresses a critical gap in ABCDE approach knowledge among Egyptian resident doctors and medical interns. The study points to the need for focused education, especially for surgeons, to improve emergency care skills and patient outcomes through continued training.
Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer
Authors: Wu Can , Zhang Xiao Wei , Wang Manman , Sun Jinpan , Chen Jianfei , Guan Yanbin , Pang Xin 
Published: January 2025

Abstract
Chemotherapy remains an effective treatment for colon cancer but is hampered by its limited response rate. Bioactive peptides, marked with intracellular transformations, have been reported as an effective approach to boosting chemotherapeutic activity. Herein, a promising trypsin-responsive bioactive peptide-based nanodrug is constructed, which could significantly prolong the drug retention time in vivo by cascading transformations and improve chemotherapeutic efficacy. Initially, 1-Pept co-assembles with Dox into a few nanofibers called 1-Pept/Dox NFs, inducing an enhanced cellular uptake via caveolae-mediated endocytosis by avoiding lysosomal degradation and further promoting perinuclear transportation, thus enlarging the drug efficacy in target areas. After nanofiber disassembly, the released 1-Pept converts into Pept under the catalysis of intracellular overexpressed trypsin, which then reassembles into denser Pept NFs, inducing a cascade of effects including disruption of the cytoskeleton, mitochondrial dysfunction, and activation of caspase-3. By the synergism of Pept NFs and Dox, caspase-3 can be further activated, and cause greater damage to nuclear, thereby leading to tumor ablation. As the first example of employing trypsin-mediated nanodrugs with cascading transformations to promote chemotherapeutic activity, this work promises a strategy for novel therapies for efficiently combating colon cancer.

Graphical Abstract
Attitudes of radiologists and interns toward the adoption of GPT-like technologies: a National Survey Study in China
Authors: Xia Tianyi , Zhang Shijun , Zhao Ben , Lei Ying , Xiao Zebin , Chen Bingwei , Zha Junhao , Yu Yaoyao , Wu Zhijun , Lu Chunqiang , Tang Tianyu , Song Yang , Wang Yuancheng , Ju Shenghong 
Published: January 2025

Abstract

Objectives
To investigate the attitudes of Chinese radiologists or interns towards generative pre-trained (GPT)-like technologies.

Methods
A prospective survey was distributed to 1339 Chinese radiologists or interns via an online platform from October 2023 to May 2024. The questionnaire covered respondent characteristics, opinions on using GPT-like technologies (in clinical practice, training and education, environment and regulation, and development trends), and their attitudes toward these technologies. Logistic regression was conducted to identify underlying factors associated with the attitude.

Results
After quality control, 1289 respondents (median age, 37.0 years [IQR, 31.0–44.0 years]; 813 males) were surveyed. Most of the respondents (n = 1223, 94.9%) supported adoption of GPT-like technologies. Based on the acceptance level of GPT-like technologies, the respondents were 3 (0.2%), 29 (2.2%), 352 (27.3%), 677 (52.5%), and 228 (17.7%) from low to high acceptance degrees. Multivariable analysis revealed significant associations between positive attitudes towards GPT-like technologies and their acceptance: writing papers and language polishing (odds ratio [OR] = 1.99; p < 0.001), influence of colleagues using such technologies (OR = 1.77; p = 0.007), government regulation introduction (OR = 2.25; p < 0.001), and enhancement of decision support capabilities (OR = 2.67; p < 0.001). Sensitivity analyses confirmed these results for different acceptance thresholds (all p < 0.001).

Conclusions
Chinese radiologists or interns generally support GPT-like technologies due to their potential capabilities in clinical practice, medical education, and scientific research. They also emphasize the need for regulatory oversight and remain optimistic about their future medical applications.

Critical relevance statement
This study highlights the broad support among Chinese radiologists for GPT-like technologies, emphasizing their potential to enhance clinical decision-making, streamline medical education, and improve research efficiency, while underscoring the need for regulatory oversight.

Key Points

The impact of GPT-like technologies on the radiology field is unclear.

Most Chinese radiologists express the supportive adoption of GPT-like technologies.

GPT-like technologies’ capabilities at research and clinic prompt the attitude.

Graphical Abstract
New or poorly known Neocomitidae (Ammonitina, Ammonoida) from the lower Hauterivian sedimentary series of the Jura platform and the Vocontian trough (France and Switzerland)
Authors: Pictet Antoine , Bulot Luc Georges 
Published: January 2025

Abstract
The Hauterivian type region and more widely the Jura mountains were investigated for their ammonites of the family Neocomitidae. Three rare lower Hauterivian genera are described here: (i) a more detailed description of Haroella charcensis Bulot, Pictet, Frau & Bryers, 2024 is given, which was identified in historical collections of ammonites from the Jura mountains, originating from a phosphatic conglomerate dating from the local Leopoldia buxtorfi Horizon and making it the oldest representative of the genus; (ii) Lyticoceras subhystricoides (Kilian & Reboul, 1915) from the Eclépens quarry is currently being revised as Theodorites cf. theodori Baraboshkin and Mikhailova, 2006; (iii) the new genus Jurienella is introduced for “Breistrofferella” peyroulensis Atrops, Autran & Reboulet 1996, previously known only to a few Provençal sections, in SE France. The stratigraphic position of the Jura specimens raises questions about the age of this taxon, as well as the phyletic link between the genera Bresitrofferella Thieuloy, 1971 and Acanthodiscus Uhlig, 1905. The Haroella-Theodorites lineage is presently considered to be separate from the Lyticoceras-Cruasiceras lineage. The Haroella-Theodorites lineage seems to originate from, or to be closely allied to the late Valanginian species Distoloceras hystrix (Phillips, 1829) sensu Neumayr & Uhlig, genotype of Distoloceras.
Early discharge and international air transport of a traveler with exacerbating comorbidities and pneumomediastinum: a case report
Authors: Akimoto Miho , Saeki Soichiro , Kiyomoto Yuki , Takeshima Hirosane , Higuchi Naofumi , Mori Takako , Osanai Yasuyo , Hinohara Chihaya , Inagaki Takeshi 
Published: January 2025

Abstract

Background
Air transport for medically complex patients presents unique challenges, particularly without specific guidelines for conditions such as pneumomediastinum or medical devices like peripherally inserted central catheters (PICC lines). Although organizations such as the Aerospace Medical Association (AsMA) and the International Air Transport Association (IATA) provide general recommendations for medical air travel, these guidelines often lack the precision required to address such complex clinical scenarios. Consequently, healthcare teams frequently face difficult decisions under constraints of time and resources, navigating the interplay of patient safety, autonomy, and logistical considerations.

Case presentation
This case involves a 30-year-old American woman with type 2 diabetes, obesity, and a recent history of pancreaticoduodenectomy, who was hospitalized in Japan with cellulitis and incidentally diagnosed with pneumomediastinum. She was treated with intravenous antibiotics and central venous nutrition administered via a PICC line. However, she requested an early discharge to return to the United States for family and financial reasons. Her travel insurer declined coverage, citing potential risks associated with pneumomediastinum. Ultimately, the patient discharged herself against medical advice; the PICC line was removed, and she transitioned to oral antibiotics for her journey home.

Conclusion
This case highlights the complexities of patient preferences, medical risks, and insurance limitations when evaluating air travel safety. The absence of specific guidelines for conditions such as pneumomediastinum and the use of medical devices highlights the need for condition-specific protocols. Effective communication and customized documentation, including modifications to the "Against Medical Advice" form proved essential in addressing both patient autonomy and the responsibilities of healthcare providers.
A preoperative misdiagnosis case: report of an enormous solitary fibrous tumor at the anterior skull base
Authors: Kong Shiqi , You Jingliang , Wang Yapeng , Yan Jingbo , Muhammad Sajjad , Zhang Rui 
Published: January 2025

Abstract

Background
Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm primarily observed in the pleura. Instances of intracranial solitary fibrous tumors are exceedingly rare. Achieving accurate preoperative diagnosis remains challenging. This report aims to enhance the understanding of this rare disease, shedding light on diagnostic intricacies, and therapeutic considerations.

Case presentation
Herein, we present a case involving an enormous SFT situated at the anterior skull base, initially misdiagnosed as meningioma. Comprehensive scrutiny of preoperative images, intraoperative observations, pathological analyses, and subsequent treatment strategies is detailed.

Conclusion
Intracranial SFT, frequently misdiagnosed radiologically as meningiomas, may originate in the subarachnoid region, emphasizing the necessity of surgical resection and the potential benefit of postoperative radiotherapy to enhance treatment efficacy.
Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes
Authors: Wulczynski Mark , Brooks Stephen P. J. , Green Judy , Matias Fernando , Kalmokoff Martin , Green-Johnson Julia M. , Clarke Sandra T. 
Published: January 2025

Abstract

Background
Environmental enrichment (EE) is commonly included as an important component of animal housing to promote well being of laboratory animals; however, much remains to be learned about the impact of chewable forms of EE on experimental outcomes in the context of nutritional and microbiome-related studies, and whether outcomes differ between sexes. In the present study, nylon chew bones (gnaw sticks, GS) were evaluated for their effects on fermentation profiles, microbial community structure, and cytokine profiles of gastrointestinal and systemic tissues in pair-housed female and male Sprague Dawley (SD) rats.

Results
Food consumption and weight gain were not significantly altered by access to GS. Cecal short-chain fatty acid and branched-chain fatty acid profiles significantly differed between sexes in rats with access to GS, and alpha diversity of the microbiome decreased in females provided GS. Sex-related tissue cytokine profiles also significantly differed between rats with and without access to GS.

Conclusions
These findings indicate that including GS can influence microbiota and immune-related parameters, in a sex dependent manner. This shows that environmental enrichment strategies need to be clearly reported in publications to properly evaluate and compare experimental results, especially with respect to the use of chewable EE in the context of studies examining diet, microbiome and immune parameters.
Leukemic cells infiltrate the ovaries without damaging ovarian reserve in an acute myeloid leukemia mouse model
Authors: Abazarikia Amirhossein , Luan Yi , So Wonmi , Becker Michelle , Panda Sipra , Swenson Samantha A , Kosmacek Elizabeth A , Oberley-Deegan Rebecca E , Xiao Shuo , Hyde Ricia Katherine , Kim So-Youn 
Published: January 2025

Abstract
Leukemia is one of the most common cancers in prepubertal girls and adolescents, with advances improving survival rates. However, treatments like chemotherapy and radiation are highly gonadotoxic, often causing ovarian insufficiency, early menopause, infertility, and endocrine disorders. Fertility preservation for young female cancer patients, especially prepubertal girls without mature germ cells, relies heavily on ovarian tissue cryopreservation. Yet, a major concern is the potential presence of leukemic cells within preserved tissue, posing a risk of reintroducing malignancy upon grafting. Additionally, the direct effects of leukemia on ovarian function remain unclear.
In this study, we used an acute myeloid leukemia (AML) mouse model to explore leukemia's impact on ovarian function. Leukemic cells infiltrated the ovaries, particularly the stromal regions and granulosa layers of antral follicles, while also being present in the spleen and liver. Despite this infiltration, ovarian structure, follicular counts, and primordial follicle reserves were largely preserved, with the notable absence of corpus luteum indicating impaired ovulation. Furthermore, leukemic infiltration induced inflammatory cytokines TNF-α and COX-2, potentially influencing ovarian health.
These findings suggest opportunities for fertility preservation by selectively removing leukemic cells, though risks of malignancy remain. This model offers a platform for advancing fertility-preservation strategies during gonadotoxic cancer therapies.
Quality and Quantity of Physical Activity Resources in the Mississippi Delta
Authors: Holmes Megan E. , Summerlin Peter , Smith Masey , Macali Ian C. , Buys David R. 
Published: January 2025

ABSTRACT

Introduction
Environmental characteristics such as public parks and recreation areas play a critical role in physical activity (PA) participation. This study examined the quality of PA resources (PARs) in the Mississippi Delta region.

Methods
As part of a community-based participatory research project, community coalitions identified 27 priority PAR intervention locations. The Physical Activity Resource Assessment (PARA) instrument was used to assess PA-related features (e.g., baseball fields), amenities (e.g., benches), and incivilities (e.g., auditory annoyance) at each PAR, which were rated using a scale ranging from 1 to 3. Quality of features, amenities, and incivilities at each PAR were also evaluated. Quality of PAR index scores (QPAR) were calculated for each location by summing the quality scores for features and amenities and subtracting the incivility score. Correlation analyses were used to examine the relationship between quantity and quality scores for all aspects of the PARA and QPAR for each location.

Results
The mean number of PA features at each location was 2.5 (range, 0–5), whereas the mean number of amenities was 5.8 (range, 1–16). QPAR was positively associated with number of PA features (r = 0.512, P < 0.05), quality of PA features (r = 0.606), number of amenities (r = 0.775), and quality of amenities (r = 0.396), and significantly (P < 0.05) inversely related to number (r = −0.559) and average rating (r = −0.476) of incivilities. Quantity of PA features was associated with quantity of amenities (r = 0.520, P < 0.05), but not incivilities. Quantity of incivilities was inversely associated with average quality of PA features (r = −0.527, P < 0.01).

Conclusions
PARs in the rural Mississippi Delta region do not have many PA features, but locations with more features tended to have more amenities, which may be useful for engaging communities for usage. Interventions should capitalize on existing PA features with strategic additions that further engage the community.
An Intervention to Reduce Occupational Health Risk from Antibiotic Resistant Pathogens Among Dairy Farm Workers
Authors: Chao Olivia , Shutske John , Gonzalez Elsie , Veeser Danielle , Diaz Vallejo Emily , Sethi Ajay , Goldberg Tony , Kates Ashley , Knobloch Mary Jo , Leite de Campos Juliana , Ruegg Pamela , Safdar Nasia , Steinberger Andrew , Suen Garret , Young Amanda 
Published: January 2025

HighlightsThis intervention utilized the Health Belief Model and Theory of Planned Behavior to address the knowledge and social barriers that increase dairy farm workers’ risk to antimicrobial-resistant infections.Dairy farm workers gained a significant increase in knowledge of the 8 desired outcomes, related to occupational health skills that reduce risks, from our intervention.Limited time was a major barrier as to why dairy farm workers felt like they could not make behavioral changes that would reduce their occupational health risk. Dairy farmworkers showed a strong likelihood of making workplace health-related behavioral changes, but their intention to change was weaker in areas of personal antibiotic stewardship.Abstract. This study focused on developing and evaluating an educational intervention designed to mitigate occupational health risks associated with pathogens and antibiotic-resistant bacteria among dairy farm workers. Data collected from farms and workers as part of a larger umbrella project that focused on dairy farm antibiotic use for cows and calves were used to inform elements of the Health Belief Model and the Theory of Planned Behavior, leading to eight intervention outcomes. The intervention targeted increased knowledge and promoted behavioral changes related to worker and workplace hygiene best practices, PPE use, biosecurity, and personal antibiotic stewardship. Educational materials included instructional videos, fact sheets in English and Spanish, and supplementary printed material, including illustrated take-home points, content summaries, and posters. The intervention was conducted with 32 workers from five dairy farms, using pre- and post-intervention assessments to measure knowledge gains and behavioral intentions. Results demonstrated statistically significant increases in knowledge across all targeted outcomes (p-value = .001), with most participants showing a high willingness and likelihood to implement recommended behaviors related to their workplace exposures and best practices. However, participants indicated a greater reluctance to change around issues of personal antibiotic stewardship. Time constraints were the most significant and most consistent barrier to behavior change. The study highlights the importance of ongoing research and refinement of intervention strategies to address barriers and enhance protective practices among often underserved farmworkers in agriculture. These intervention strategies contribute to improved occupational health outcomes with benefits to public health by reducing the spread of antibiotic-resistant infections to the broader population. Keywords: Antibiotic resistance, Dairy farmworkers, Educational intervention, Infectious disease, Occupational health.
Potential use of Spirulina sp. as fish feed : A mini review
Authors: Prameswari Rhiana , Andriani Yuli , Gumilar Iwang , Hasan Zahidah 
Published: January 2025

Spirulina sp. is one of the microalgae that is used as natural food for fish seeds or larvae. Spirulina sp. contains 60–71% protein, 8% fat, 16% carbohydrates, and vitamins as well as 1.6% Chlorophyll- a, 18% Phycocyanin, 17% β-Carotene, and 20–30% γ-linoleaic acid from total fatty acids. Cultivation of Spirulina sp. can be done using organic media and inorganic media. The types of inorganic media that can be used are Urea, TSP, Zarrouk, Conwy and Walne, while the organic media that can be used are vermicompost, quail droppings, guano, liquid waste from banana stems, coconut husks, canna plants, fermented Azolla pinnata , and bioslurry . The cultivated Spirulina can be used as fish feed in either fresh or dried form. Several research results show that giving Spirulina sp. flour had a significant effect (P0.05) on the growth and brightness of fish color with additional concentrations in the range of 1.2-10 grams/100 grams of feed