bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Outcomes and Continence Following Robotic-Assisted Radical Cystectomy with Mainz Pouch II Urinary Diversion in Patients with Bladder Cancer
Authors: Jing Suoshi , Yang Enguang , Luo Zuoxi , Zhang Yunxin , Ding Hui , Yang Li , Dong Zhilong , Shang Panfeng , Yue Zhongjin , Wu Gongjin , Bao Junsheng , Tian Junqiang , Wang Jiaji , Xiao Nan , Wang Zhiping 
Published: November 2023

Abstract
PURPOSE
To present the widely unknown perioperative outcomes and continence statuses of bladder cancer patients following robotic-assisted radical cystectomy (RARC) with Mainz Pouch II urinary diversion (UD).
MATERIALS AND METHODS
From November 2020 to December 2022, 37 bladder cancer patients who underwent RARC with Mainz pouch II UD were retrospectively assessed (ChiCTR2300070279). Patient demographics, perioperative data, continence, and complications (early ≤ 30 days and late > 30 days) were all documented. A numeric rating scale assessed patient satisfaction with urinary continence 30 days after surgery.
RESULTS
Of the 37 patients evaluated over a median (range) follow-up period of 11.8 (1.6–24.5) months. The median (range) age was 65 (40–81) years. The median (range) time to urinary continence after surgery was 2.3 (1.5-6) months. Of the 37 patients, 31 (83.6%) were continent both during the day and at night, 34 (91.9%) were continent during the day, 32 (86.5%) were continent at night, 35 (94.6%) were satisfied with their urinary continence status, and 21 (56.8%) were very satisfied. The mean (range) voiding frequency was 6 (4–10) during the day and 3 (2-5.5) at night. Five (13.5%) patients experienced late complications.
CONCLUSIONS
Mainz pouch II UD following RARC in bladder cancer patients results in a satisfactory continence rate, and the intracorporeal approach to Mainz pouch II UD works better for female patients due to its reduced invasiveness.
TRIAL REGISTRATION
ChiCTR2300070279; Registration: 07/04/2023, Last updated version: 01/06/2023. Retrospectively registered.
The effects of physical exercise on physical fitness and executive function in children with excessive body weight
Authors: Zhang Mingyang , Qian Guoping , Ma Junchi , Li Shunchang , Lipowski Mariusz , Ossowski Zbigniew 
Published: November 2023

Abstract
Objective: The purpose of this study was to evaluate the impact of 11 weeks physical exercises on physical fitness and executive functions in children with excessive body weight.
Methods: In the first phase, 61 six-year-old children were divided into 3 groups according to the degree of obesity: 17 in the normal weight group (NW), 24 in the overweight group (OW), 20 in the obesity group (OB). In the second phase, 56 participants from the first phase who wished to participate in the exercise program were divided into 3 groups as described above. The physical exercise program lasted 40 minutes daily, 4 days a week for 11 weeks, including 5 min warm-up exercise, 30-min physical exercise training and 5 min cool-down stage. Then, all participants were tested before and after the experiment for body composition, physical fitness, executive functions and saliva analysis test. Body composition was measured by height, weight, body mass index (BMI), and percentage of body fat (%BF). Physical fitness was measured by cardiopulmonary fitness, muscle strength, speed sensitivity, and flexibility quality. Executive function was measured by animal go/no-go task, working memory span task, simple reaction test and flexible item selection task. Saliva GH and IGF-I concentrations was assayed with Human IGF-I ELISA.
Results: Apart from height, all parameters measuring body composition were higher in the obesity group than in the other groups (p < 0.05). Moreover, physical fitness and executive function also were significantly worse in the overweight and obesity groups compared with the normal group (p < 0.05). SalivaGH and IGF-I was significantly lower in the obesity group than in the normal and overweight groups(p < 0.0001), but did not differ between the normal and overweight groups (p >0.001).
After exercise intervention, no statistical difference of upper limb muscular strength among three groups (p > 0.05). Among physical fitness variables, the lower limb muscular strength, flexibility quality, speed sensitivity, and cardiopulmonary were significantly improved in the overweight group (p < 0.05); All executive function parameter were higher in the normal and overweight groups than obesity group, except for cognitive flexibility, such as inhibitory control, working memory, and reaction time (p < 0.05). in addition, physical exercise significantly increased saliva GH and IGF-I concentrations in children with obesity (p < 0.05).
Conclusion: 11-week physical exercise can improve the physical fitness and executive functions of 6-year-old overweight children. Furthermore, the findings were
positively associated with the degree of obesity. Thus, our study highlights the importance of exercise prescription for the effective prevention and treatment of childhood obesity considering the obesity degree.
Asymptotic Dynamic Graph Order Evolution Analysis
Authors: Bridonneau Vincent , Guinand Frédéric , Pigné Yoann 
Published: November 2023

Abstract

In this work, we investigate the analysis of generators for dynamic graphs, which are defined as graphs whose topology changes over time. We focus on generated graphs whose order (number of nodes) varies over time. We introduce a novel concept, called ”sustainability,” to qualify the long-term evolution of dynamic graphs. A dynamic graph is considered sustainable if its evolution does not result in a static, empty, or periodic graph. To illustrate how the analysis can be conducted, a parameterized and probability-based generator, named D3G3 (Degree-Driven Dynamic Geometric Graphs Generator), has been introduced in a recent work. From this model, we derive multiple scenarios that correspond to three trends in graph order evolution. Our central contribution lies in a mathematical framework that provides an expectation of the order of the graph at time step t + 1, given its order at time step t. Nevertheless, our analysis underscores the challenge of characterizing the sustainability of dynamic graphs, even when a formal mathematical model for graph order evolution is known.
Risk of transmission of SARS-CoV-2 on international flights, a retrospective cohort study using national surveillance data in England
Authors: Howkins Joshua , Packer Simon , Walsh Eleanor , Kumar Deepti , Edeghere Obaghe , Hickman Matthew , Oliver Isabel 
Published: November 2023

Abstract
Background
It is not yet fully understood to what extent in-flight transmission contributed to the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This study aimed to determine the occurrence and extent of SARS-CoV-2 transmission in-flight and assess factors associated with transmission risk to inform future control strategies.
Methods
Retrospective cohort study using data obtained from contact tracing of international flights arriving in England between 02/08/2021–15/10/2021. Transmission risk was estimated by calculating the secondary attack rate (SAR). Univariable and multivariable analyses of the SAR by specific risk factors was undertaken, including: number of in-flight index cases; number of symptomatic index cases; contact vaccination status; flight duration; proximity to the index case(s); contact age.
Results
11,307 index cases linked to 667,849 contacts with 5,289 secondary cases reported. In-flight SAR was 0.79% (95% CI: 0.77–0.81). Increasing numbers of symptomatic cases (when > 4 index cases compared to one index case aOR 1.85; 95% CI: 1.40–2.44) and seating proximity to an index case (within compared to outside of two rows OR 4.34; 95% CI: 3.69–5.11) were associated with increased risk of secondary cases. Full vaccination history was protective (aOR 0.52; 95% CI: 0.47–0.57).
Conclusions
This study confirms that in-flight transmission of SARS-CoV-2 occurred. There are factors associated with increased risk of infection. Contact tracing identified exposed persons who subsequently developed infection. A targeted approach to contact tracing passengers with the highest exposure risk could be an effective use of limited public health resources.
Efficacy and Safety of Choline Alphoscerate for Amnestic Mild Cognitive Impairment: A Randomized Double-Blind Placebo-Controlled Trial
Authors: Jeon Jong-Wook , Lee Su-Young , Lee Seung Hoon , Han Chang-Woo , Park Geum Duck , Kim Se-Joo , Chang Jhin Goo , Kim Woo Jung 
Published: November 2023

Abstract

Background
Effective interventions for overall healthy subjects with mild cognitive impairment are currently limited. Choline alphoscerate (alpha glyceryl phosphorylcholine, αGPC) is a choline-containing phospholipid used to treat cognitive function impairments in specific neurological conditions. This study aimed to investigate the efficacy and safety of αGPC in individuals diagnosed with mild cognitive impairment.
Methods
In this multicenter, randomized, placebo-controlled trial, 100 study subjects with mild cognitive impairment underwent double-blind a 727 mg SHCog™ soft capsule (equivalent to 600 mg aGPC) or placebo treatment for 12 weeks. The primary efficacy outcome included changes from baseline on the Alzheimer’s Disease Assessment Scale–cognitive subscale (ADAS-Cog). Safety assessments included regular monitoring of adverse events, and clinical laboratory tests were conducted at baseline and the end of the trial.
Results
After 12 weeks of αGPC treatment, the ADAS-Cog score decreased by 2.34 points, which was significantly greater than the change observed in the placebo group. No serious AEs were reported, and no study subjects discontinued the intervention because of AEs. There was no significant difference in incidence rate of AEs between the αGPC group and the placebo group.
Conclusion
This study suggests that αGPC is a safe and effective intervention for improving cognitive function in study subjects with mild cognitive impairment.
Trial registration:
Clinical Research Information Service; Osong (Chungcheongbuk-do): Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare (Republic of Korea); KCT0008797; A 12-week, multicenter, randomized, double-blind, placebo-controlled human application study to evaluate the efficacy and safety of SH_CAPK08 on cognitive function improvement in mild cognitive decline.
On obesogenic diet exposure of parents and sex-specific programming of overweight in mouse offspring
Authors: Czechowski Paul , Hoffmann Anne , Dommel Sebastian , Blüher Matthias , Klöting Nora 
Published: November 2023

Abstract

Background/Objectives:
Whether parental obesity alters the probability that a child will become an obese adult is not fully understood. Thus, we were interested in exploring how parents’ obesity status influence their offspring’s weight. We further asked whether exposure to milder forms of maternal or paternal obesity during early developmental stages induces programming of long-term overweight in offspring, and if this effect may be sex specific.
Subjects/Methods:
We randomly assigned three-week-old mice to two groups, one group receiving a high-fat diet (HFD), the other group receiving a control diet (CD). Adult females of both groups were mated to males fed with HFD or CD. Each group consisted of four females and two males (one female deceased).
Interventions/methods:
After analysing weight gain trajectories of parental (P) and filial (F1) individuals, we investigated F1 transcriptome assay data from four tissues (liver, epigonal visceral, inguinal subcutaneous, and interscapular brown adipose tissue) of 15 male offspring in relation to their parents’ obesity status.
Results
DEGs were only considered significant when false discovery rate adjusted p values were p < 0.05, and the log2-fold change was at least 1. In brown adipose tissue of male offspring with both parents being obese, when compared to males with only a father obese, expression patterns suggested a higher degree of insulin resistance, impaired muscle growth and regeneration, altered impulse control, and possibly, protection against diet–induced obesity. In liver, the contrast between offspring to obese parents and those to not-obese parents was characterized by expression differences related to fatty acid metabolism, water homeostasis, inflammation and others.
Conclusions
We provide transcriptomic support for the hypothesis that having two obese parents, rather than having only one obese parent, further amplifies risks for obesity and metabolic disease among males.
An experimental investigation of the pile-soil interface characteristics in cold region under varying exposure temperature and accumulated permanent deformation under freezing-thawing cycles
Authors: Liu Hui , Niu Fuijun 
Published: November 2023

Abstract
The creep behavior of the frozen soil-structure interface as the research point in this paper subjected to mechanism theory principles of water-thermal coupling cycle was exhibited. There are mainly three situations, one is pile uplifting in the freezing heave period owing to frost heave force, then soil melt, and the pile would keep stable which the skin friction supported the pile at interface, three is both cases acting as stated above, the positive frozen cohesive is not enough to support the pile in frozen soil combined the negative friction at the same time. The frost heave with creep effect analysis was given the mainly concern. The emphasis of the frost heave phenomenon considering inner shear behavior under different geometric parameters in Freezing-Thawing cycle pointed that creep effect of the soil-pile interface played a domain role in the total deformation of interface due to common source of the settlement and uplift in cold regions.
It reveals that the actual strain rate was sensitive at deeper soil layer by layer towards ground, according to the good agreement between the relaxation data and secondary creep conditions. The best fit regression was occurred in the period of approximate 65 th day to 200 th day accordingly. The strain mainly presents promoted when the temperature are below-2℃ in freezing transmission period, while it shows reduction trend with water content increase to ice-rich soil.
It is taken for that with flow rate varying with stress conditions which exceed a yield stress level. And it shown the relationship of stress and strain at various depths with diminished lay-up character distribution. The numerical calculated result was shown that the high cohesion concentration zone be in the position of-2m depths of pile.
And the mechanism model can be described by Kelvin-Voigt model, with validating by experimental simulation and published literature. Above all, it can be seen the temperature and moisture were the most significant effects for interface frost heave, which is indicated by the shear creep response analyzing. The combination of factors closely associated with the cohesion leading the pile continuously uplifting. The creep effect worked on the interface separated by three stage of primary creep stage, secondary creep stage and tertiary creep stage in frozen and thawing period by different cohesion force. So the characteristics of creep combined the Kelvin Voigt model was presented in this paper.
Virtual reality as an acute pain reliever during laceration repair in emergency departments: a randomized controlled trial
Authors: Rezai Mahdi , Namdari Leili , Farsi Davood , Ashayeri Neda , Naghshbandi Mobin , Hariri Mohsen , Ghafoury Roya 
Published: November 2023

Abstract
Introduction: Virtual Reality (VR) is a promising distraction technique that immerses the participant in a 3-dimensional virtual presence. The purpose of this study is to investigate the effect of VR on reducing pain in adult patients during laceration repair in the emergency department (ED).
Methods: This is a randomized clinical trial conducted in the EDs of Rasoul Akram, Haftom-e-Tir and Firouzgar hospitals, all under supervision of Iran University of Medical Sciences. A total of 160 patients with laceration that needed suturing were divided into two equal groups of 80 patients; One group received the VR glasses during the suturing while the other group did not receive them. All patients in both groups received local analgesics. The pain intensity of the patients before and after the intervention was obtained using a numerical scale (from 1 to 10). Patient satisfaction was measured in terms of pain reduction based on a Likert scale: 1=bad, 2=poor, 3=moderate, 4=good, 5=excellent. The collected data of pain intensity and patient satisfaction were compared before and after the intervention.
Results: The average age of patients in the VR+ group and VR- group was 37.04 ± 17.21 and 39.18 ±5.09 years, respectively. The average pain intensity of VR+ patients before and after using VR glasses were 4.87 ± 1.2 and 2.13 ± 1.32, respectively, of which demonstrated a significant reduction in the pain intensity of VR+ patients (P-value =0.028). The level of VR+ patients' satisfaction in terms of pain intensity before and after using VR glasses was 1.44 ± 0.52 and 3.23 ± 0.64, respectively, indicating a significant increase in the patients' satisfaction in terms of pain reduction after using VR glasses (P-value =0.033).
Conclusion: VR has a positive effect on attenuating patients' pain and increasing their satisfaction in terms of pain reduction.
A novel therapy-oriented acetabular defects classification based on quantitative assessment statistical shape models
Authors: Wang Jiang , Guo Fengjin , Qi Jun , Yang Qing , Cheng Peng , Zhang Jinming , Yuan Ke , Zhang Xu , Qin Liang 
Published: November 2023

Abstract
Background: The purposes of this study was to develop a novel therapy‑oriented acetabular bone defects classification system based on Statistical shape models (SSMs) and evaluate the reliability and reproducibility of its application.
Methods: We retrospectively reviewed and annotated pelvic Computed tomography (CT) of patients who had undergone revision total hip arthroplasty at our institution and constructed a dataset to develop the novel method for quantitatively describing acetabular bone defects that is based on SSMs. Then, using this method, classification systems are suggestive for diagnosis and corresponding treatment suggestion. In addition, the interobserver and intraobserver reliability of this classification system compared to the Paprosky classification system was calculated.
Results: The novel classification based on SSMs was successfully applied to 106 hips, Incidences of type A, B, C, D and E were 25.5%, 41.5%, 13.2%, 14.2% and 5.7%, respectively. Compared to the Paprosky classification, the novel classification system demonstrated a higher level of interobserver and intraobserver reliability for diagnosis (0.828 and 0.844) and treatment suggestions (0.828 and 0.844).
Conclusion: This classification system, which has demonstrated moderate to strong interobserver and intraobserver reliability, may be particularly useful to accurately evaluate acetabular defects and suggest surgical strategies, as a complement to the traditional Paprosky classification system in revision THA.
Assessment of Post-Surgical Quality of Life in Patients with Angiomatous Meningioma
Authors: de Araújo Mayle , Negromonte Pedro , Santana Luiz , Silva Inaê da , Faquini Igor , Junior Auricélio , Filho Hildo 
Published: November 2023

Abstract
Introduction: Meningiomas, which account for 36.4 per cent of intracranial neoplasms, predominantly affect women after the age of 50. Angiomatous meningiomas (AM), which account for 2.1% of all meningiomas, are characterised by high vascularity, which poses a challenge during surgery due to the increased risk of intraoperative haemorrhage. Objective: The aim of this study was to assess quality of life in patients with AM after surgical resection, with a focus on physical and emotional aspects.
Methods: The study retrospectively analysed patients with AM who underwent surgery between 2019 and 2023 at Hospital da Restauração, Pernambuco, using the NFBrSI-24 questionnaire. Pre- and post-operative data were collected, including neurological deficits and headache intensity.
Results: Of the 13 patients, 76 per cent were female, with an average age of 50.3 years. The most common preoperative symptoms included headache (30%), motor deficits (23%) and nausea/vomiting (15%). Postoperatively, improvements were seen in motor and sensory deficits, as well as a significant reduction in headache intensity. Post-operative NFBrSI-24 scores increased by an average of 15.9 points, indicating an improvement in quality of life, especially in physical and emotional aspects.
Conclusions: This study is the first to investigate post-surgical quality of life in patients with AM, suggesting that surgery improves their quality of life, especially in the physical and emotional domains.
Distribution characteristics and resource potential evaluation of low grade solid potassium in Qarhan Salt Lake
Authors: Wang Di , Zhang Hua , Liu Chenglin , Jiao Peng-Cheng 
Published: November 2023

Abstract
China is one of the countries with the largest demand for potash fertilizer in the world, and Qarhan Salt Lake is the largest potash deposit in China. It is a comprehensive deposit mainly composed of liquid potassium-rich brine resources and associated solid potassium salt minerals, which contains about 296 million tons of low-grade solid potassium salt. In recent years, potassium-rich brine resources are declining due to long-term mining. Solid potassium salts have become important development objects, and the development of solid-liquid conversion technology makes these low-grade solid potassium salts become exploitable deposits with great potential. Bieletan section is the first area of Qarhan Salt Lake to carry out low-grade solid potash mine development experiment. In this paper, 3D geological modeling and resource evaluation were carried out by collecting data from 55 drill holes in the Bieletan area, exploring the spatial partial characteristics and resource distribution of low-grade solid potassium in the area, and providing quantitative data support and the basis of mineral search for subsequent potash resource development.