bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart rate variability in patients with acute ST-segment elevation myocardial infarction after COVID-19
Authors: Mikhin V. P. , Osipova O. A. , Gindler A. I. , Brizhaneva A. S. , Zaikina N. V. , Zaikina M. P. , Nikolenko T. A. , Savelyeva V. V. , Chernyatina M. A. 
Published: November 2023

Aim. To compare heart rate variability parameters in patients after a coronavirus disease 2019 (COVID-19) with acute ST elevation myocardial infarction (STEMI) during the inhospital and post-hospital periods.Material and methods. A total of 140 patients with STEMI were divided into 2 groups: I — patients with STEMI who had COVID-19 (n=52) in the period of 1,5-6 months before acute coronary syndrome, II — comparison group (n=88), which included patients with STEMI without prior COVID-19. All patients underwent infarct-related artery stenting within the first 24 hours from the onset. Heart rate variability (HRV) parameters were determined for all patients on days 2-3 and days 9-11 and 6 months after the hospitalization for STEMI.Results. Patients in group I showed more pronounced changes in HRV indicators on days 2-3 of STEMI: RMSSD (root square of successive RR intervals) by 21% (p=0,026), variations (Var) (the difference between the minimum and maximum RR intervals) by 33% (p=0,013), VLF (total very low-frequency HRV) by 7% (p=0,009) were higher, and HF (highfrequency HRV) by 40% (p=0,003), pNN50% (ratio of the number of consecutive RR interval pairs differing by >50 ms to the total number of RR intervals) by 66% (p=0,038) were lower than in the control group, respectively. On days 9-11 of the disease in patients with a history of STEMI and COVID-19, in contrast to the control group, there was a more pronounced increase in the SDNN (standard deviation of RR intervals) by 46% (p=0,005), VLF by 42% (p=0,031), whereas in the control group there were an increase of only 22% (p=0,004) and 11% (p=0,022), respectively. The HF value in the main group increased by 25% (p=0,007), while in the control group it decreased by 19% (p=0,030). Six months after STEMI in the main group, the RMSSD decreased by 19% (p=0,009), Var by 16% (p=0,041), VLF by 30% (p=0,025), LF (low-frequency component HRV) by 11% (p=0,005), while the control group these parameters decreased by 20% (p=0,006), 21% (p=0,001), 9% (p=0,011), and 7% (p=0,016), respectively.Conclusion. In patients with STEMI and prior COVID-19, the initial HRV values differ from similar HRV parameters in patients with STEMI without prior COVID-19. In the hospital and post-hospital periods, the changes of HRV in patients with and without COVID-19 are multidirectional as follows: pronounced sympathetic hyperactivity predominates, and slower recovery of HRV in patients after COVID-19 predominates.
24-hour blood pressure profile and systemic inflammation in patients with stable coronary artery disease with obstructive sleep apnea
Authors: Osipova O. A. , Gosteva E. V. , Zhernakova N. I. , Shepel R. V. , Ponomarenko T. N. , Inshakova K. Yu. , Drapkina O. M. 
Published: November 2023

Aim. To evaluate 24-hour blood pressure (BP) profile and systemic inflammation in patients with coronary artery disease (CAD) depending on the presence of obstructive sleep apnea (OSA).Material and methods. This cross-sectional cohort study included 132 patients with CAD aged 62,3±6,9 years. Depending on OSA, all patients were divided into 2 groups: group 1 (n=60) — without OSA, group 2 (n=72) — with OSA. Systemic inflammation was assessed using neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), Systemic immune-inflammation index (SII) — platelets´neutrophils/lymphocytes. Blood pressure was monitored with assessment of average daily values, circadian rhythm, and variability.Results. Patients with OSA had higher nighttime blood pressure values (p<0,05) and 24-hour variability (p<0,05). In group 2 patients, a pathological blood pressure profile was detected in 66,7% of cases, while in group 1 — in 36,7%. The systemic inflammation indices were significantly higher in patients with OSA than in the group without OSA — NLR by 18,8% (p<0,01), PLR by 22,5% (p<0,01), MLR by 19,0% (p<0,01), SII by 41,0% (p<0,001).Conclusion. We established that patients with coronary artery disease and OSA have more pronounced systemic inflammation, more often have a pathological 24-hour BP profile ("non-dipper", "night-peaker"), BP variability, higher values of average 24-hour, daytime and nighttime BP compared with patients without OSA.
Long-term outcomes of renal denervation in the treatment of comorbid patients with hypertension, diabetes and coronary atherosclerosis
Authors: Arablinsky N. A. , Feshchenko D. A. , Rudenko B. A. , Shukurov F. B. , Vasiliev D. K. , Drapkina O. M. 
Published: November 2023

Aim. To study the clinical effects and long-term outcomes of catheterbased renal denervation (CRD) in patients with cardiovascular disease and diabetes.Material and methods. This single-center prospective observational study included 60 patients with uncontrolled hypertension, type 2 diabetes, and coronary artery disease after complete endovascular revascularization. Patients were divided into 30 groups into the CRD group and the control group. CRD was performed via femoral access using a Spyral catheter (Medtronic, USA). The primary endpoint was the change in glycemic levels after 12 months.Results. In the CRD group, a significant decrease in basal glycemia level from 9,3 (7,67-10,12) to 6,05 (5,2-8,3) mmol/l, glycated hemoglobin from 7,6 (6,98,4) to 6,6 (6,2-7,2)%, Homeostasis Model Assessment Insulin Resistance (HOMA-IR) from 6,6 (3,73-11,2) to 4,76 (2,73-7,1) — in the absence of significant changes in the control group. A significant decrease in the average level of office systolic (-14 (-24; -10) mm Hg, p=0,0002) and diastolic blood pressure (-10 (-10; -6) mm Hg, p=0,0002), p=0,0007) was also revealed — in the absence of significant changes in the control group. There were no significant differences in late lumen loss between the groups: 21,8% (17,3-28,8) in the CRD group vs 26,3% (19,5-34,0) in the control group (p=0,09).Conclusion. A positive effect of CRD on carbohydrate metabolism in patients with type 2 diabetes, hypertension and coronary artery disease was revealed. The hypothesis of the pleiotropic effects of CRD was confirmed.
Clinical and genetic characteristics of the first Russian patient with a syndrome of craniofacial dysmorphia-deafness-anomalies of the upper limbs, caused by a mutation in the <i>PAX3</i> gene
Authors: Markova T. V. , Mavlyukeeva V. V. , Ginzburg B. G. , Shchagina O. A. , Nikitin S. S. , Dadali E. L. 
Published: November 2023

Craniofacial dysmorphia-deafness-anomalies of the upper limbs is a rare autosomal dominant syndrome caused by variants in the PAX3 gene. In contrast to the two main nosological forms – Waardenburg syndrome types 1 and 3, caused by variants in this gene, the syndrome of craniofacial dysmorphias-deafness-anomalies of the upper limbs is not characterized by the presence of hair hypopigmentation and heterochromia of the iris, while congenital contractures of the wrist and interphalangeal joints of the hands. There is a description in the literature of three patients from the same family with a syndrome caused by the c.141C>G(p.Asn47Lys) variant in the PAX3 gene. Aim of the work is to present the clinical and genetic characteristics of the first Russian patient with the syndrome of craniofacial dysmorphia-deafness-anomalies of the upper extremities.Molecular genetic analysis of a 1-year and 10-month-old proband with phenotypic signs of the syndrome of craniofacial dysmorphia-deafness-anomalies of the upper limbs was carried out by direct automatic Sanger sequencing of the entire coding sequence of the PAX3 gene. Genotyping of parents was carried out by direct automatic sequencing according to Sanger. Sequencing was carried out on an ABIPrism3500хI instrument (Applied Biosystems) in accordance with the manufacturer’s protocol; primer sequences were selected according to the reference sequence of the target regions of the PAX3 gene (NM_181459.4).In Russian proband 1 year 10 months-old, the phenotypic characteristics of the syndrome of craniofacial dysmorphia-deafness-anomalies of the upper limbs did not differ from the description of sick family members presented in the literature. A molecular genetic study revealed a heterozygous variant c.141C>G(p.Asn47Lys) in the PAX3 gene in the presented patient.
Methodology of botulinum therapy in the treatment of dystonic scoliosis in generalized dystonia (clinical case)
Authors: Misikov V. K. , Kovalenko A. P. , Kondur A. A. 
Published: November 2023

Dystonic scoliosis as one of the forms of generalized dystonia is a highly disabling form of dystonia, which can lead to damage to internal organs (lungs, heart) and the peripheral nervous system, including the spinal cord. Almost always, those muscles that are involved in the formation of a dystonic posture in generalized dystonia have not been studied in terms of the effectiveness of treatment with botulinum toxin type A and are not reflected in the instructions. As a result, there is no understanding of the general motor interaction with differentiation into targeted and non-targeted muscles, administration doses and control methods.The aim of the work was to evaluate the efficacy and tolerability of high doses of botulinum toxin type A in dystonic scoliosis, as well as to present the introduction of botulinum toxin type A using ultrasound and electromyographic control. We have described a clinical case of a 19-year-old patient suffering from generalized dystonia with S-shaped dystonic scoliosis of the III degree. Deep brain stimulation was recommended as a treatment for the patient. During the waiting period for the timing of the operation, we attempted symptomatic therapy using the drug incobotulotoxin A. Over the next year and a half, 700 units of botulinum toxin type A were administered under ultrasound and electromyographic control every 3–4 months. As a result, treatment of trunk dystonia in the patient during the observation period led to a clinically significant decrease in the degree of curvature (from 37° to 27°, from III to II degree of scoliosis) in the absence of undesirable effects of the drug, including generalized muscle weakness. According to the repeated conclusion of the council of neurosurgeons, surgical intervention is not indicated for the patient due to the positive effect of the introduction of botulinum toxin type A.
Features of gene polymorphism associations linked with sex hormone binding globulin level and breast cancer of various molecular biological subtypes
Authors: Pasenov K. N. , Ponomarenko I. V. , Churnosov M. I. 
Published: November 2023

Aim: to identify specific associations between genes polymorphism associated with sex hormone-binding globulin (SHBG) level and breast cancer (BC) of various molecular biological subtypes.Materials and Methods. The retrospective comparative study was conducted using specimens collected from 261 patients with BC of two molecular biological subtypes – luminal A/B (n = 153) and triple negative (n = 108) as well as 1140 women in control group. All study participants (n = 1401) underwent a molecular genetic study of four single nucleotide polymorphism (SNP) loci, which showed a relationship with circulating SHBG level in previously conducted genome-wide association study (GWAS): rs12150660 SHBG, rs10454142 PPP1R21, rs780093 GCKR, rs17496332 PRMT6.Results. The analysis revealed an association between SHBG SNP candidate genes and a BC risk in patients with luminal A/B subtypes and lacked significant associations between the loci assessed and triple negative BC subtype. CC female genotype of rs10454142 PPP1R21 increased a risk of luminal A/B subtypes BC by more than 2-fold (recessive model [CC vs. TC+TT]; odds ratio = 2.07; 95 % confidence interval = 1.14–3.77; p = 0.017; pperm = 0.018). This SNP is localized in functionally "significant" regions of the genome (enhancers/active enhancers, promoters/active promoters) and affects methylation level in several hepatocyte DNA sites [cg15846641 (chr2:48541264)].Conclusion. The genetic variant rs10454142 PPP1R21 is associated with the risk of developing ВС luminal A/B subtypes, but not with ВС triple negative subtype.
Удосконалений метод стиснення цифрових зображень, як частини відеопотоку для попередньої обробки даних перед їх шифруванням
Authors: Рябий М.О. , Кінзерявий О.М. , Проскурін Д.П. , Сорокопуд В.І. 
Published: November 2023

Актуальна задача над якою постійно працюють фахівців з конкретних предметних галузей залишається зменшення обсягу відео та фото інформації при збереженні якісного зорового сприйняття. Проте, не ставлячи під сумнів успіхи розробників методів стиснення (як з втратами, так і без втрат), зменшення розміру при потоковому передаванні відео інформації, несе погіршення якості інформації, що доволі сильно помітні для людського ока або спотворюють інформацію так, що її подальша обробка стає неможливою. В роботі запропоновано загайний вигляд методу підвищення рівня (відсотка) стиснення ЦЗ (як частини відеопотоку з БПЛА) з втратами, на основі перетворень, що забезпечують інваріантність ЦЗ та методів виділення фону.
Ensino de história antirracista e a Lei 10.639/03
Authors: Mautone Ferreira Rafael , Ferreira da Silva Gilberto 
Published: November 2023

A Lei Nacional 10.639, sancionada em 2003, que obriga o Ensino da história e Cultura Afro-brasileira nas escolas é uma das conquistas, preconizada pelos movimentos sociais, particularmente, pelo movimento negro brasileiro. Neste trabalho, nosso objetivo se volta para compreender as contribuições que a Cultura Hip Hop pode aportar ao ensino de história na educação básica, tomando por foco as práticas curriculares voltadas ao último ano do ensino fundamental. Lançando mão da ideia de educabilidades, examina-se, desde a gênese do Hip Hop até as formas atuais de expressões próprias desta cultura. Nessa direção despontam, em especial, a Técnica da Sampleagem e da Mixagem como potenciais recursos para exercitar na docência do ensino de história. Dentre os destaques se observa a potencialidade que se apresenta nestas práticas culturais que ainda precisam ser melhores tratadas no ambiente do currículo escolar e no ambiente da escola de forma mais ampliada. Acreditamos que tanto os profissionais da educação (professores) quanto a comunidade e os estudantes são convocados a exercitar o protagonismo, ao conhecer, praticar e reconhecer a cultura hip hop, uma vez que o uso das técnicas implica em processos coletivos, abertos e interativos de aprendizagem.
Penerapan Metode Fuzzy Multi Criteria Decision Making Pada Interpretasi Hasil Penentuan Kemiskinan Provinsi Jawa Timur
Authors: Diya Hakimatul Maulidiyah , Turmudi Turmudi 
Published: November 2023

Fuzzy Multi Criteria Decision Making (FMCDM) method is a method of making decisions based on certain criteria to determine the best alternative among several alternatives. The purpose of the FMCDM method is to obtain the best alternative that is accurate and optimal. Poverty is a condition in which economic needs are not met against the average standard of living in the region. Poverty is a very important issue for the government or related agencies. This problem can be solved by determining the district/city area which is included in the poor category. So a method is needed that can be used to determine the existence of poverty in an area. The solution to overcome this problem is to use the FMCDM method. The solution to overcome this problem is to use the FMCDM method. The FMCDM process begins by determining objectives, alternative decisions, and a collection of criteria that will be used to determine poor districts/cities in East Java Province. The alternative decisions consist of 38 regencies/cities of East Java Province, while the set of criteria consists of the Percentage of Poor People, Human Development Index, Poverty Depth Index, and Poverty Severity Index. The next step evaluates the fuzzy set by aggregating the weight of the criteria and the degree of fit of each alternative to its criteria. The aggregation result is called the fuzzy match index which consists of three values, namely, the value which represents the result of the lower limit aggregation, the value which represents the middle bound, and the value which represents the upper bound value. The three values are ranked using the ranking method for fuzzy numbers with degrees of optimasan. So that the total integral value for each alternative will be a decision from the highest priority to the lowest in determining the districts / cities included in the poor category and as an effort to reduce poverty in East Java Province.
Les Mutuelles d’Assistance Funeraire dans les Perspectives Socioeconomiques a Bouake (Cote d’Ivoire)
Authors: Jean-Aimé Assué Yao , Issoufou Diallo , Kouakou Koffi Justin 
Published: November 2023

Cet article analyse la dynamique des mutuelles d’assistance funéraire et de leur impact socioéconomique dans les espaces urbains en Côte d’Ivoire. En effet, Bouaké, à l’instar de certaines villes ivoiriennes s’illustre dans ces dernières années par un nombre croissant de mutuelles d’assistance funéraire. Ce travail de recherche a adopté les méthodes quantitatives et qualitatives. À cet effet, les entretiens et les questionnaires menés respectivement auprès des responsables des différentes structures et des mutualistes révèlent que dans les différentes mutuelles interrogées à Bouaké, de 2008 à 2022, le nombre total d’adhérents est passé de 1734 à 36642. Par ailleurs, le nombre de mutuelles d’assistance funéraire sur la même période est passé de 7 à 14. Aussi, les montants des assistances sont-ils passés de 100.000 F CFA à 1.000.000 F CFA par mutualiste. En somme, l’on constate une multiplication des adhésions dans l’ensemble de ces mutuelles enquêtées. Cet engouement autour de ces mutuelles s’explique par plusieurs raisons, entre autres, la spontanéité et l’importance des prestations financières consistantes. Ces mannes financières sont dans l’ensemble, réinvesties dans des activités génératrices de revenus ou l’immobilier.

This article analyzes the dynamics of funeral assistance mutuals and their socio-economic impact in urban spaces in Côte d'Ivoire. Indeed, Bouaké, like some Ivorian towns, has distinguished itself in recent years by a growing number of mutual funeral assistance funds. This research work adopted both quantitative and qualitative methods. To this end, the interviews and questionnaires conducted respectively with the heads of the various structures and the mutualists reveal that in the various mutuals questioned in Bouaké, from 2008 to 2022, the total number of members increased from 1,734 to 36,642., the number of mutuals of funeral assistance over the same period rose from 7 to 14. Also, the amounts of assistance increased from 100,000 CFA francs to 1,000,000 CFA francs per mutualist. In short, there is an increase in membership in all of the mutuals surveyed. This enthusiasm for these mutuals can be explained by several reasons, among others, the spontaneity and the importance of consistent financial services. These financial windfalls are generally reinvested in income-generating activities or real estate.
Acoustic-Hydraulic Nozzle for Fine Spray and High Performance
Authors: Kudryashova Olga , Shalunov Andrey , Genne Dmitry , Dorovskikh Roman , Titov Sergey 
Published: November 2023

Spray technology is widely used in various industries, including medicine, food production, mechanical engineering, and nanopowder manufacturing. Achieving high dispersion and a narrow particle size distribution is crucial for many applications. Ultrasonic spraying is commonly used to achieve this. On other hand, hydraulic nozzles provide high atomization performance. Combining these two technologies promises to offer significant benefits, but the complex processes that occur simultaneously in such a device require careful study. This work proposes a fundamental design for an acoustic-hydraulic nozzle and investigates the physical processes when a liquid is sprayed using this nozzle, both theoretically and experimentally. The study identifies the critical modes of spraying and confirms that the simultaneous use of ultrasound and hydraulic pressure can produce a fine spray (droplet size less than 50 μm) with high productivity (5-10 ml/s). This approach has significant potential for modern industries and technologies.
Anaesthetic Management during Balloon Atrial Septostomy in Transposition of Great Arteries
Authors: Subroto Devina Ravelia Tiffany , A'malia Ulya , Wibowo Ardian 
Published: November 2023

<strong>Background: </strong>Transposition of the great arteries (TGA) is a congenital heart defect that can cause death in 30% of the first week of birth, 50% in the first month, 70% in 6 months, and 90% in the first year, thus requiring immediate corrective action in neonates with rapid early detection. The purpose of this case study is to highlight management considerations in TGA cases in the Balloon Atrial septostomy (BAS) procedure.<p><strong>Discussion:</strong> A 1-day-old newborn girl was brought to Dr. Moewardi General Hospital in February 2022. The patient had a history of cyanosis when she cried and was born with an APGAR score of 6.7.8. The lips were cyanotic on physical examination, with a SpO2 of 77% with a nasal O2 of 2 lpm. The echocardiography results obtained TGA, ASD II, PFO, and PDA. The patient then underwent a BAS procedure. Anesthesia management was performed using ketamine for induction, air bar, O2, and sevoflurane for maintenance of anesthesia. The operation was successful, and postoperative care was carried out. Anesthesia management aims to keep SVR and PVR to a minimum, with a PVR lower than SVR, to prevent desaturation in the patient. A decrease in PVR also can increase pulmonary blood flow, allowing more blood to be mixed and higher oxygen saturation in the blood for the patient.</p><p><strong>Conclusion:</strong> The principle of anesthesia management in TGA cases is to avoid a reduction in cardiac output and SVR and keep the PVR lower than the SVR.</p>