bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delta-radiomics analysis based on magnetic resonance imaging to identify radiation proctitis in patients with cervical cancer after radiotherapy
Authors: Xue Jing , Wu Menghan , Zhang Jing , Yang Jiayang , Lv Guannan , Qu Baojun , Zhang Yanping , Yan Xia , Song Jianbo 
Published: January 2025

ObjectivesTo develop a magnetic resonance imaging (MRI)-based radiomics model for predicting the severity of radiation proctitis (RP) in cervical cancer patients’ post-radiotherapy.MethodsWe retrospectively analyzed clinical data and MRI images from 126 cervical squamous cell carcinoma patients treated with concurrent chemoradiotherapy. Logistic regression (LR), Pearson correlation coefficient, and least absolute shrinkage and selection operator (LASSO) methods were utilized to select optimal imaging features, leading to a combined prediction model developed using a random forest (RF) algorithm. Model performance was assessed using the area under the curve (AUC), DeLong test, calibration curve, and decision curve analysis (DCA), with Shapley Additive exPlanations (SHAP) values for interpretation.ResultsThe samples were split into training (70%) and validation (30%) sets. The delta-radiomics model, comprising 10 delta features, showed strong predictive performance (AUC: 0.92 for training and 0.90 for validation sets). A comprehensive model combining delta-radiomics with clinical features outperformed this, achieving AUCs of 0.99 and 0.98. DeLong’s test confirmed the comprehensive model’s statistical superiority, and both calibration curves and DCA indicated good calibration and high net benefit. Key features associated with RP included D1cc, T1_wavelet-LLL_glcm_MCC, D2cc, and T2_original_firstorder_90 Percentile.ConclusionsThe MRI-based delta radiomics model shows significant promise in predicting RP severity in cervical cancer patients following radiotherapy, with enhanced predictive performance when combined with clinical features.
Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study
Authors: Chen Li-Qiong , Zhou Yong-Can , Ning Fang , Zhu Ming-Jin 
Published: January 2025

BackgroundTraditional Chinese medicine has a good clinical therapeutic effect on perimenopausal insomnia, Jiawei Suanzaoren Tang (JW-SZRT) has a significant therapeutic effect on people with yin deficiency and fire excess type insomnia.MethodFirstly, 80 cases of perimenopausal yin deficiency and fire excess type insomnia were included in the study. The treatment group was treated with Jiawei Suanzaoren decoction, while the control group was treated with lorazepam for 4 weeks. The study observed and compared the Pittsburgh Sleep Quality Index (PSQI), Kupperman score, Polysomnography (PSG) and sex hormone levels of two groups before and after treatment. Secondly, we also conducted network pharmacology analysis and mechanism research. We first searched public databases for the targets of the compound known tobe associated with JW-SZRT, as well as those predicted to be targets of insomnia, and then used software Cytoscape 3.7.2, GO and KEGG to identify enriched gene pathways and networks. Networks and pathways that overlapped between Insomnia-associated proteins and JW-SZRT target proteins were then used to predict candidate protein targets of JW-SZRT in insomnia. Finally, 40 rats were selected in animal experimentation and 30 perimenopausal insomnia rat models were created through ovariectomy and a modified multi-platform water environment 72-hour sleep deprivation method. The model group received normal saline, the western medicine group received lorazepam suspension, and the Chinese medicine group received Jiawei Suanzaoren decoction. The sham surgery group was given routine feeding. The sleep condition, the levels of blood hormone levels and the expression levels of 5-Hydroxytryptamine (5-HT) and Gamma-Aminobutyric Acid receptor A (GABAA) receptor in the hypothalamus were compared between groups.ResultsIn clinical observation, the sleep condition and the changes of hormone levels between the treatment group and the control group were statistically significant (P &lt; 0.05). The results of network pharmacology indicate that in the main signaling pathways for treating insomnia, it is speculated that Jiawei Suanzaoren Tang can regulate the signaling pathway of neuroactive ligand receptor interactions by inhibiting the activation of related proteins, thereby improving sleep. Animal experiments have also shown that the JW-SZRT can significantly improve the sleep conditions of insomnia rats during perimenopause, and the expression levels of 5-HT and GABAA receptors in the hypothalamus had a significant difference between groups in animal experiments (P &lt; 0.05).ConclusionJiawei Suanzaoren Decoction can improve the perimenopausal insomnia. The mechanism behind this improvement may be related to the regulation of Estradiol (E2), Follicle-Stimulating Hormone (FSH), and luteinizing hormone (LH) levels, as well as the mRNA expression levels of 5-HT1a, 5-HT2a, GABAARα1, and GABAARγ2 receptors in the hypothalamus.
Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment
Authors: Song Peiji , Li Kun , Xu Xiaodie , Zhang Guifeng , Wang Zengkun , Sun Linbing , Zhao Zekai , Li Ting , Wang Ximing , Xia Zhangyong 
Published: January 2025

ObjectiveThis study aims to investigate the protective effects of Cordyceps sinensis against renal injury induced by low-dose contrast medium (CM) in coronary computed tomography angiography (CCTA) imaging, and to evaluate its efficacy using functional magnetic resonance imaging (fMRI).MethodsTwenty Beagle dogs with induced renal insufficiency were enrolled in the study and randomly assigned to one of four groups (n = 5 per group). Group A received Cordyceps sinensis for 1 week prior to undergoing heart rate-dependent personalized CM CCTA scanning; Group B received Cordyceps sinensis for 1 week followed by conventional dose CM CCTA scanning; Group C did not receive Cordyceps sinensis but underwent HR-dependent CM CCTA scanning; and Group D did not receive Cordyceps sinensis but underwent conventional dose CM CCTA scanning. Renal function was assessed using MRI before and after the intervention, with IVIM (Intravoxel Incoherent Motion) and BOLD (Blood Oxygen Level Dependent) imaging of the kidneys. Key parameters, including the pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), and R2*values, were quantified. Laboratory renal function markers were measured multiple times before and after the intervention, and their correlation with fMRI parameters was analyzed.ResultsCCTA imaging revealed that the CT values of the major coronary artery branches in all groups met the international diagnostic criteria for coronary arteries. No statistically significant differences in image quality were observed among the four groups (P &gt; 0.05). In Groups A and D, significant changes were observed in renal function parameters, as well as in D, D*, f, and R2* values, both pre- and post-CCTA (P &lt; 0.05). However, Groups B and C exhibited no significant changes pre- and post-CCTA (P &gt; 0.05). A significant correlation was found between MRI parameters and laboratory renal function markers, with excellent inter- and intra-observer reproducibility, and high repeatability in the measurements.ConclusionHR-dependent personalized CM CCTA imaging did not compromise image quality. Administration of Cordyceps sinensis demonstrated a potential protective effect on renal function. The combination of IVIM and BOLD functional MRI offers a reliable, non-invasive approach to assess the protective effects of Cordyceps sinensis on renal injury induced by low-dose CCTA in Beagle dogs.
Optimal dose of oxytocin to improve social impairments and repetitive behaviors in autism spectrum disorders: meta-analysis and dose–response meta-analysis of randomized controlled trials
Authors: Zhang Yingying , Zhang Xiaolu , Huang Linghong 
Published: January 2025

IntroductionSocial impairments and repetitive behaviors are at the core symptoms of autism spectrum disorder (ASD). Intranasal administration of the neuropeptide oxytocin (OXT) is a promising treatment. However, there have been inconsistencies in the effects of OXT on social impairments and repetitive behaviors.MethodsA comprehensive search in PubMed, the Cochrane Library, Embase, and Web of Science was conducted to gather randomized controlled trials (RCTs) on the efficacy of OXT in patients diagnosed with ASD up to 11/06/2024. The core outcomes were social impairments measured by total Social Responsiveness Scale (SRS) scores and repetitive behaviors measured by the Repetitive Behavior Scale (RBS).ResultsThis meta-analysis ultimately included 12 RCTs with 498 ASD patients. In an initial analysis, intranasal OXT showed no significant effect on social impairments. For a high dose of 48 IU per day, a beneficial effect on social impairments was found. According to the dose–response meta-analysis, the results indicated that higher doses of OXT might be more effective for social impairments. Depending on repetitive behaviors, the overall analysis showed no significant effect, while the dose over 48 IU per day revealed significant results and the dose–response meta-analysis suggested that higher doses could be more effective for repetitive behaviors.DiscussionAlthough these findings show no consistent beneficial effects, the results of the dose–response meta-analysis suggest that high doses of intranasal OXT per day may be more effective in ASD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024567213.
Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis
Authors: Worku Nigusu , Workie Amare Mesfin , Yohannes Lamrot , Getnet Mihret , Negash Wubshet Debebe , Yeshambel Belay Adina , Asmare Lakew , Alemu Hiwot Tadesse , Geberu Demiss Mulatu , Jejaw Melak , Demissie Kaleb Assegid , Tiruneh Misganaw Guadie , Hagos Asebe 
Published: January 2025

BackgroundGlobally, inappropriate feeding practices account for more than two-thirds of all cases of child mortality during the first 2 years of a child’s life. For a long time, Ethiopia has suffered from the double burden of malnutrition: overnutrition and undernutrition both pose significant challenges, particularly for children. Undernutrition is mainly caused by wealth and educational disparities across the country. Therefore, this study aimed to assess the socio-economic inequalities in minimum dietary diversity (MDD) practices among Ethiopian children aged 6–23 months and the potential contributing factors.MethodsThe study utilized the recent datasets of the Ethiopia Mini Demographic and Health Survey (EMDHS) of 2019. A total of 1,511 weighted samples were included in the research. Microsoft Excel and STATA v.14 software were employed to extract, clean, and analyze data. A probit model decomposition analysis was performed. The concentration index (CIX) and curve were used to examine household wealth status and maternal education level inequalities in the MDD.ResultsThe total weighted prevalence of MDD among children under the age of 5 in Ethiopia was 13.5%. Wealth and educational status show positive CIX values for inequality, as exhibited by the concentration curve under the equality line. The CIX with household and maternal education status were (CIX: 0.1034, p &lt; 0.0029) and (CIX: 0.1057, p &lt; 0.0002), respectively. This indicates a greater concentration of inequalities among privileged women. The decomposition analysis revealed that household wealth status, (58.23%) contributed by wealth status, (36.38%) place of delivery, (30.47%) maternal education, and (21.5%) administration region, explained the pro-rich inequalities in MDD in Ethiopia.ConclusionThis study identified significant inequalities in terms of wealth and maternal educational level in the context of MDD. Policymakers and healthcare workers should develop effective strategies to tackle the underlying causes of inequalities in attaining MDD, specifically focusing on household wealth and maternal education.
A qualitative study of parental caregiving experience in adolescents with depression from the perspective of positive psychology in China
Authors: Zhao Yueyan , Miao Qunfang , Xin Siying , Li Peiqing , Huang Yaoyao 
Published: January 2025

ObjectiveTo explore the inner experiences and needs of parents of adolescents with depression in the caregiving process, to understand the problems they encounter, and to provide precise intervention and support strategies for this group from a positive psychology orientation.MethodsUse of qualitative research methods, semi-structured interviews were conducted with 12 parents of adolescents with depression, selected from December 2022 to October 2023. Colaizzi′s seven-step analysis method was used to extract themes.ResultsThe parental caregiving experience for adolescents with depression can be grouped into 3 themes and 8 sub-themes: ① Complex negative emotions (negative emotions at the beginning of diagnosis, negative emotions during the caregiving process); ② Adversity experienced by individuals and families (increased physical and financial burdens, lack of access to professional support information, family dysfunction); ③ Coping and adaptation to adversity (self-growth, actively seeking outside assistance, enhanced family connection).ConclusionParents of adolescents with depression have complex caregiving experiences and face numerous difficulties and challenges at different stages of treatment. Caregivers and medical social workers should focus on the inner experiences and needs of parents at various stages of caregiving. Establishment of a joint care model with a positive psychology perspective to enhance individual and family psychological resilience and a sense of disease benefit.
The impact of COVID-19 pandemic on sleep duration and mental health among middle school students: a 3-year cross-sectional survey
Authors: Dou Kai-yun , Dong Ru-bao , Gan Chun-long 
Published: January 2025

BackgroundSince the outbreak of COVID-19 in late 2019, and until the Chinese government downgraded the pandemic control measures to Category B management in January 2023, various epidemic prevention measures were implemented across regions based on the local spread of the virus. Correspondingly, educational formats shifted between online and offline teaching according to the pandemic situation. Changes in daily life and teaching methods, along with the high initial mortality rate of COVID-19, have had varying degrees of negative impact on the mental health (MH) of adolescents.PurposesThis study aimed to explore the impact of the COVID-19 pandemic status on the sleep duration (SD) and MH of adolescents, investigate the relationship between SD and MH in middle school students, and evaluate the protective effect of SD on MH.MethodsUsing a convenient sampling method, 6 junior high schools and 3 senior high schools in Guiyang City, China, were selected. Random samples from two classes per grade in each school were chosen for the survey. The study was conducted annually for three consecutive years using the Mental Health Inventory of Middle-school students (MMHI-60) scale and a self-designed questionnaire. Data were analyzed using IBM SPSS version 26.0 software, employing ANOVA, cross-tabulation, and generalized linear models to examine the relationship between SD and MH scores.ResultsThe SD and MH scores of middle school students in 2021, 2022, and 2023 were 436.41 ± 71.21 min/day, 423.69 ± 61.71 min/day, and 445.26 ± 65.04 min/day (F = 41.44, p &lt; 0.001), 1.72 ± 0.63, 1.87 ± 0.73, and 1.79 ± 0.67 (F = 18.31, p &lt; 0.001). The SD compliance rates were 34.1%, 23.9%, and 33.2%, and the MH problem detection rates were 27.9%, 36.4%, and 33.4%, respectively; there is a significant correlation between SD and MH scores among middle school students (P &lt; 0.001); the protective effects of SD compliance on MH were 1.859 times, 2.156 times, and 1.516 times higher than those of SD non-compliance (all p &lt; 0.001).ConclusionMeeting the SD standard is a protective factor for adolescent MH. The COVID-19 pandemic and its control measures have had a severe and long-term negative impact on both SD and MH in middle school students, with differences observed between genders and academic levels. The greater the severity of the pandemic and the stricter the control measures, the more significant the negative impact on SD and MH etc.
Depressive symptoms and its influencing factors of older people with cataracts in China: a national cross-sectional survey
Authors: Niu Tengfei , Cao Shiwei , Wang Xiaoyu , Xian Xiaobing , Luo Chunyang , Ma Jingxi 
Published: January 2025

BackgroundDepressive symptoms are a common complication in patients with cataracts and may exacerbate cataract symptoms. Therefore, it is important to focus on depressive symptoms and their influencing factors in older people with cataracts. The purpose of this study was to investigate the prevalence rate of depressive symptoms and influencing factors in Chinese older people with cataracts.MethodsDescriptive analyses were used to report the sociodemographic characteristics, lifestyle, health status, and depressive symptoms of old people with cataracts in China. The chi-square test was used to compare differences between subjects with different demographic characteristics. Binary logistic regression was used to analyze the factors that influenced the depressive symptoms of cataract patients. Meanwhile, a random forest model was developed in this study to rank the importance of the influencing factors.ResultsThree hundred and six (25.27%) of 1,211 cataract patients included in this study suffered from depressive symptoms. Logistic regression analysis suggested that poor economic situation (AOR = 3.162, 95%CI: 1.719–5.817), social participation (AOR = 1.530, 95%CI: 1.053–2.222), having hearing disorder (AOR = 1.445, 95%CI: 1.040–2.008), poor self-reported health status (AOR = 2.646, 95%CI: 1.705–4.106), poor life satisfaction (AOR = 3.586, 95%CI: 1.652–7.784) were risk factors for depressive symptoms in cataract patients and consumption of fresh fruits (AOR = 0.587, 95%CI: 0.369–0.933) was a protective factor for depressive symptoms in cataract patients. The results of the random forest showed that self-reported health status was the most important factor influencing depressive symptoms in cataract patients. The other factors, in order of importance, were life satisfaction, economic situation, fruits, hearing disorder, and social participation.ConclusionThe results suggested that the development of depressive symptoms in cataract patients was influenced by various factors. Medical staff should monitor these influencing factors more closely when treating and caring for patients with cataracts.
Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review
Authors: Negro Giulia , Rossi Michele , Imbimbo Camillo , Gatti Alberto , Magi Andrea , Appollonio Ildebrando Marco , Costa Alfredo , Poloni Tino Emanuele 
Published: January 2025

IntroductionBehavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course of dementia and impact caregiving. Among these, the Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation (HIDA) and Psychosis (P) domains are particularly challenging to manage. Despite their prevalence, their underlying mechanisms and neuropathological correlates, remain poorly understood. This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms.MethodsThe review follows PRISMA guidelines, with a systematic search conducted across MEDLINE, CENTRAL, and EMBASE databases. Inclusion criteria involved studies exploring the neuropathology of the HIDA and psychosis domains in individuals with dementia. Records were screened using PICO software, and data quality was assessed using the Newcastle-Ottawa Scale (NOS) and CARE guidelines. A narrative synthesis was conducted due to heterogeneity in the data.ResultsFrom 846 records identified, 37 studies met inclusion criteria. Of the 18,823 cases analyzed, the most common diagnoses were Alzheimer's Disease (83.44%), Dementia with Lewy Bodies (5.37%), and Frontotemporal Dementia (13.40%). HIDA-P symptoms were distributed across all clinical diagnoses, with agitation (14.00%), delusions (11.60%), disinhibition (7.61%), and hallucinations (6.83%) being the most frequently reported behaviors. The primary neuropathological diagnosis was Alzheimer's Disease Neuropathologic Change (ADNC), present predominantly in intermediate to severe forms. The neuropathological analysis revealed the co-occurrence of multiple proteinopathies, particularly TAUopathy, TDP-43 pathology, and Lewy-related pathology (LRP), with the latter, in association with ADNC, reported in 15 studies.DiscussionHIDA-P symptoms were linked with overlapping involvement of different neural circuits, particularly the amygdala and the broader limbic system. Evidence suggests that TAUopathy and multiple proteinopathies in key brain regions, such as amygdala, are central to the development of these symptoms. In contrast, the contribution of beta-amyloid and vascular damage appears marginal in the genesis of HIDA and psychotic symptoms. No behavioral symptom is pathognomonic of a specific proteinopathy; rather, the topography and severity of lesions plays a more decisive role than their single molecular composition.Systematic review registrationINPLASY2024100082.