bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of tricuspid valve stenosis after pacemaker implantation with infective endocarditis
Authors: Song Lin , Qin Xiaoli , Li Xuejie , Zuo Yunxia 
Published: January 2024

AbstractA 68‐year‐old male patient was admitted for extremities edema and diagnosed with infective endocarditis (IEIE). The patient underwent mitral and aortic valve mechanical valve replacement due to rheumatic heart valve disease 26 years ago. He underwent mechanical aortic valve and bioprosthetic tricuspid valve replacement due to mechanical aortic valve dysfunction and severe tricuspid valve regurgitation 1 year ago. Two months ago, the patient underwent emergency permanent pacemaker implantation due to syncope caused by a third‐degree atrioventricular block. The patient was admitted to the emergency with fever and worsening dyspnea 1 h ago. Transthoracic echocardiography revealed prosthetic aortic valve severe paravalvular leak and tricuspid valve stenosis with vegetation. The patient was scheduled to undergo mechanical aortic valve and bioprosthetic tricuspid valve replacement under median thoracotomy. The intraoperative transesophageal echocardiography (TEE) view showed severe paravalvular aortic valve leakage and tricuspid valve vegetation. The coronary sinus was significantly enlarged with thrombus formation, vegetation can be seen in the bioprosthetic tricuspid valve leaflets. This is a rare case of infective endocarditis with tricuspid stenosis and coronary sinus thrombosis after the placement of implanted pacemakers.
Clinical impact of cerebral protection during transcatheter aortic valve implantation
Authors: Boccuto Fabiola , Carabetta Nicole , Cacia Michele Antonio , Kanagala Sai Gautham , Panuccio Giuseppe , Torella Daniele , De Rosa Salvatore 
Published: January 2024

AbstractBackgroundEmbolization of debris can complicate transcatheter aortic valve implantation (TAVI) causing stroke. Cerebral embolism protection (CEP) devices can divert or trap debris.PurposeTo evaluate the efficacy of CEP during TAVI vs the standard procedure.Data SourcesPubMed, SCOPUS and DOAJ 1/01/2014–04/12/2023.Study SelectionRandomized and observational studies comparing CEP versus standard TAVI, according to PRISMA. Primary outcome: stroke. Secondary outcomes: death, bleeding, vascular access complications, acute kidney injury and infarct area.Data ExtractionTwo investigators independently assessed study quality and extracted data.Data SynthesisTwenty‐six articles were included (540.247 patients). The primary endpoint was significantly lower (RR = 0.800 95%CI:0.682–0.940; p = 0.007) with CEP. Similarly, death rates were significantly lower with CEP (RR = 0.610 95%CI:0.482–0.771; p < 0.001). No difference was found for bleeding (RR = 1.053 95%CI:0.793–1.398; p = 0.721), vascular complications (RR = 0.937 95%CI:0.820–1.070; p = 0.334) or AKI (RR = 0.982 95%CI:0.754–1.279; p = 0.891).ConclusionsUse of CEP during TAVI is associated with improved outcomes. Future studies will identify patients who benefit most from CEP.
Complex sequential learning is not facilitated by transcranial direct current stimulation over DLPFC or M1
Authors: Kaminski Elisabeth , Carius Daniel , Knieke Jan , Mizuguchi Nobuaki , Ragert Patrick 
Published: January 2024

AbstractTranscranial direct current stimulation (tDCS) is a non‐invasive brain stimulation technique which was found to have a positive modulatory effect on online sequence acquisition or offline motor consolidation, depending on the relative role of the associated brain region. Primary motor regions (M1) and dorsolateral prefrontal cortices (DLPFC) have both been related to sequential learning. However, research so far did not systematically disentangle their differential roles in online and offline learning especially in more complex sequential paradigms. In this study, the influence of anodal M1 leg area‐tDCS and anodal DLPFC‐tDCS applied during complex sequential learning (online and offline) was investigated using a complex whole body serial reaction time task (CWB‐SRTT) in 42 healthy volunteers. TDCS groups did not differ from sham tDCS group regarding their response and reaction time (online) and also not in terms of overnight consolidation (offline). Sequence specific learning and the number of recalled items also did not differ between groups. Results may be related to unspecific parameters such as timing of the stimulation or current intensity but can also be attributed to the relative role of M1 and DLPFC during early complex learning. Taken together, the current study provides preliminary evidence that M1 leg area or DLPFC modulation by means of tDCS does not improve complex sequential skill learning.Significance statementUnderstanding motor learning is helpful to deepen our knowledge about the human ability to acquire new skills. Complex sequential learning tasks have only been studied, sparsely, but are particularly mimicking challenges of daily living. The present study studied early motor learning in a complex serial reaction time task while transcranial direct current stimulation (tDCS) was either applied to leg primary motor cortex or bilateral dorsolateral prefrontal cortex. TDCS did not affect sequential learning, neither directly during performance nor in terms of sequence consolidation. Results provide preliminary information that M1 or bilateral DLPFC modulation does not improve early complex motor learning.
Soil organic carbon content and stock in Martinique – relations to near infrared spectra
Authors: Barthès Bernard G. , Venkatapen Corinne , Cambou Aurélie , Blanchart Eric 
Published: January 2024

AbstractThis data paper presents observations on soil organic carbon (SOC) gravimetric and volumetric contents (SOCg, in g kg−1, and SOCv, in g dm−3, respectively) for 98 profiles at least 30 cm deep (1 m deep for 59 of them), in rural areas of the Martinique island, in relation to soil types and land uses and management. The paper also presents particle size distribution down to 30 cm, and near infrared reflectance (NIR) spectra for the main soil types. This dataset allows evaluating the effects of land use, soil type and texture on SOC content and stock, at regional scale. It also allows inferring SOCg, SOCv and particle size distribution from NIR spectra. Such information is useful for studying and managing soils in the Martinique island and in other tropical volcanic regions.
RE‐START: Exploring the effectiveness of anti‐calcitonin gene‐related peptide resumption after discontinuation in migraine
Authors: Romero del Rincón Celia , Gonzalez‐Martinez Alicia , Quintas Sonia , García‐Azorín David , Fernández Lázaro Iris , Guerrero‐Peral Angel Luis , Gonzalez Osorio Yesica , Santos‐Lasaosa Sonia , González Oria Carmen , Sánchez Rodríguez Norberto , Iglesias Díez Fernando , Echavarría Íñiguez Ana , Gil Luque Sendoa , Huerta‐Villanueva Mariano , Campoy Díaz Sergio , Muñoz‐Vendrell Albert , Lozano Ros Alberto , Sánchez‐Soblechero Antonio , Velasco Juanes Fernando , Kortazar‐Zubizarreta Izaro , Echeverría Amaya , Rodríguez‐Vico Jaime , Jaimes Sánchez Alex , Gómez García Andrea , Morollón Sánchez‐Mateos Noemí , Belvis Robert , Navarro Pérez María Pilar , García‐Moncó Juan Carlos , Álvarez Escudero María Rocío , Montes Nuria , Gago‐Veiga Ana Beatriz 
Published: January 2024

AbstractBackground and purposeAccording to the latest European guidelines, discontinuation of monoclonal antibodies against calcitonin gene‐related peptide (anti‐CGRP MAb) may be considered after 12–18 months of treatment. However, some patients may worsen after discontinuation. In this study, we assessed the response following treatment resumption.MethodsThis was a prospective study conducted in 14 Headache Units in Spain. We included patients with response to anti‐CGRP MAb with clinical worsening after withdrawal and resumption of treatment. Numbers of monthly migraine days (MMD) and monthly headache days (MHD) were obtained at four time points: before starting anti‐CGRP MAb (T‐baseline); last month of first treatment period (T‐suspension); month of restart due to worsening (T‐worsening); and 3 months after resumption (T‐reintroduction). The response rate to resumption was calculated. Possible differences among periods were analysed according to MMD and MHD.ResultsA total of 360 patients, 82% women, with a median (interquartile range [IQR]) age at migraine onset of 18 (12) years. The median (IQR) MHD at T‐baseline was 20 (13) and MMD was 5 (6); at T‐suspension, the median (IQR) MHD was 5 (6) and MMD was 4 (5); at T‐worsening, the median (IQR) MHD was 16 (13) and MMD was 12 (6); and at T‐reintroduction, the median (IQR) MHD was 8 (8) and MHD was 5 (5). In the second period of treatment, a 50% response rate was achieved by 57.4% of patients in MHD and 65.8% in MMD. Multivariate models showed significant differences in MHD between the third month after reintroduction and last month before suspension of first treatment period (p < 0.001).ConclusionThe results suggest that anti‐CGRP MAb therapy is effective after reintroduction. However, 3 months after resumption, one third of the sample reached the same improvement as after the first treatment period.
Misfolded alpha‐synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment
Authors: Smith Richard , Hovren Hanna , Bowser Robert , Bakkar Nadine , Garruto Ralph , Ludolph Albert , Ravits John , Gaertner Lia , Murphy Davan , Lebovitz Russ 
Published: January 2024

AbstractBackgroundAlpha‐synuclein (α‐Syn) oligomers and fibrils have been shown to augment the aggregation of TAR DNA‐binding Protein 43 (TDP‐43) monomers in vitro, supporting the idea that TDP‐43 proteinopathies such as ALS may be modulated by the presence of toxic forms of α‐Syn. Recently, parkinsonian features were reported in a study of European patients and Lewy bodies have been demonstrated pathologically in a similar series of patients. Based on these and other considerations, we sought to determine whether seed‐competent α‐Syn can be identified in spinal fluid of patients with ALS including familial, sporadic, and Guamanian forms of the disease.MethodsBased on the finding that α‐Syn has been found to be a prion‐like protein, we have utilized a validated α‐Synuclein seed amplification assay to determine if seed‐competent α‐Syn could be detected in the spinal fluid of patients with ALS.ResultsToxic species of α‐Syn were detected in CSF in 18 of 127 ALS patients, 5 of whom were from Guam. Two out of twenty six samples from patients with C9orf72 variant ALS had positive seed‐amplification assays (SAAs). No positive tests were noted in superoxide dismutase type 1 ALS subjects (n = 14). The SAA was negative in 31 control subjects.ConclusionsOur findings suggest that a sub‐group of ALS occurs in which self‐replicating α‐Syn is detectable and likely contributes to its pathogenesis. This finding may have implications for the diagnosis and treatment of this disorder.
Investigation on damage creep constitutive model of rock under the coupled effect of freeze–thaw cycles and loading
Authors: Shi Sheng , Zhu Fengjin , Zhu Jiancai 
Published: January 2024

AbstractThe investigation on damage creep properties of rock under freeze–thaw conditions are essential for assessing the long‐term stability of rock mass engineering in cold regions. This research analyzed the damage characteristics of rock under the coupled effect of freeze–thaw cycles and loading; the damage variable under the coupled effect of freeze–thaw cycles and loading was proposed. A damage creep constitutive model was developed, and the determination method for the model parameters was proposed. The rationality of the model was calibrated using test data, and the calculation results of the proposed model were compared with classical Nishihara model. Additionally, the research analyzed the variation of model parameters with the number of freeze–thaw cycles and discussed the damage creep mechanisms of rock under the coupled effect of freeze–thaw cycles and loading.
The sensitivity of risk premiums to the elasticity of intertemporal substitution
Authors: Wu Zhiting 
Published: January 2024

AbstractThis paper incorporates reference‐dependent preferences into a consumption‐based asset pricing model featuring Epstein–Zin utility. Three relevant results emerge from this extension. First, agents prefer the late resolution of uncertainty in recursive utility. Second, the late resolution of uncertainty helps replicate the downward‐sloping term structure of market excess return. Third, the intertemporal substitution elasticity is more sensitive to asset prices through increasing precautionary saving motivations. A closed‐form solution for the proposed model largely explains (i) high, volatile, and countercyclical equity premiums; (ii) low risk‐free rates; and (iii) the downward‐sloping term structure of equity premiums and variance ratios.
Actual conditions for returning home after hospitalization among older patients receiving home medical care in Japan: OHCARE Study
Authors: Murakami Naoko , Kabayama Mai , Yano Tomoko , Nakamura Chika , Fukata Yuka , Morioka Chihiro , Fang Wen , Nako Yumiko , Omichi Yuki , Koujiya Eriko , Godai Kayo , Kido Michiko , Tseng Winston , Wada Taizo , Nakamura Toshinori , Hirotani Atsushi , Fukuda Toshio , Tamatani Michio , Okuda Yoshinari , Ikushima Masashi , Baba Yoshichika , Nagano Masahiro , Nakamura Yukio , Rakugi Hiromi , Kamide Kei 
Published: January 2024

AimTo examine the actual conditions of older patients receiving home medical care after hospitalization over a period of 2 years in Japan.MethodsThe study population included 102 participants, aged ≥65 years, receiving home medical care, who consented to participate in the Osaka Home Care Registry (OHCARE) study in Japan over a period of 2 years. We investigated the actual conditions for returning home after hospitalization.ResultsThe median age of the 102 participants was 84 years, and 61 (59.8%) were women. In the group that returned home, 42 (55.3%) of the respondents desired to recuperate in a familiar place, as in advanced care planning (ACP). During the 2‐year follow‐up period, the group that did not return home had significantly more deaths. A multivariate analysis showed the association in the presence of ACP (odds ratio: 4.72, 95% confidence interval: 1.60–13.86) and cardiac disease (odds ratio: 0.25, 95% confidence interval: 0.08–0.76). The lack of ACP in the medical records when the patient was admitted to the hospital may have prevented the return home.ConclusionIn older patients who had difficulty returning home after hospitalization, the lack of ACP in home medical care may have been an influencing factor. ACP could help continue with home medical care. Geriatr Gerontol Int 2024; 24: 320–326.
Transcriptional features of low‐grade neuroepithelial tumors with the BRAF V600E mutation associated with epileptogenicity
Authors: Iijima Keiya , Komatsu Kanako , Miyashita Satoshi , Suyama Kyoka , Murayama Kumiko , Hashizume Koichi , Tabe Nao K. , Miyata Hajime , Iwasaki Masaki , Taya Shinichiro , Hoshino Mikio 
Published: January 2024

AbstractLow‐grade neuroepithelial tumors are major causes of drug‐resistant focal epilepsy. Clinically, these tumors are defined as low‐grade epilepsy‐associated neuroepithelial tumors (LEATs). The BRAF V600E mutation is frequently observed in LEAT and linked to poor seizure outcomes. However, its molecular role in epileptogenicity remains elusive. To understand the molecular mechanism underlying the epileptogenicity in LEAT with the BRAF V600E genetic mutation (BRAF V600E‐LEAT), we conducted RNA sequencing (RNA‐seq) analysis using surgical specimens of BRAF V600E‐LEAT obtained and stored at a single institute. We obtained 21 BRAF V600E‐LEAT specimens and 4 control specimens, including 24 from Japanese patients and 1 from a patient of Central Asian origin, along with comprehensive clinical data. We submitted the transcriptome dataset of 21 BRAF V600E‐LEAT plus 4 controls, as well as detailed clinical information, to a public database. Preliminary bioinformatics analysis using this dataset identified 2134 differentially expressed genes between BRAF V600E‐LEAT and control. Additionally, gene set enrichment analysis provided novel insights into the association between estrogen response‐related pathways and the epileptogenicity of BRAF V600E‐LEAT patients. Our datasets and findings will contribute toward the understanding of the pathology of epilepsy caused by LEAT and the identification of new therapeutic targets.
Assessing wound complications in gastroscopy with Streptomyces protease enzyme combined with Shutai
Authors: Chen Qihui , Li Hangfei , Zhou Lijuan , Yang Zhanbo 
Published: January 2024

AbstractCurrent gastroscopy practices necessitate a balance between procedural efficiency and patient safety. It has been hypothesized that increasing procedure outcomes through the use of Streptomyces protease enzyme and Shutai is possible; however, precise nature of any potential adverse reactions and complications remains unknown. In Zhanjiang, China, 213 patients undergoing gastroscopy participated in this controlled trial. The subjects were allocated at random into two groups: control and treatment. The treatment group was administered topical Streptomyces protease enzyme and intravenous Shutai. Using chi‐square and t‐tests, information regarding patient demographics, adverse reactions, wound healing, procedure duration, distress levels, and satisfaction was gathered and analysed. The demographic and medical history characteristics of the groups were comparable. There was a greater prevalence of modest immediate reactions in the treatment group (p < 0.05), whereas there were no significant variations observed in delayed reactions and long‐term complications (p > 0.05). The treatment group exhibited superior efficiency metrics, including shorter durations for diagnosis, procedure completion and recuperation (p < 0.05). The treatment group exhibited significantly higher patient satisfaction scores (p < 0.05). The incorporation of Streptomyces protease enzyme and Shutai into gastroscopy procedures resulted in significantly enhanced level of procedural efficacy and patient contentment while not introducing an additional risk of long‐term complications. The increase in moderate immediate reactions that have been observed requires additional research in order to determine their clinical significance. Although these agents present a possible progression in the field of gastroscopy, their application should be tempered by the immediate adverse reactions that have been documented.
High pyroelectric performance and its dependence on the field‐induced orientation in antiferroelectric PLZST system
Authors: Adukkadan Anil , Ranjan Rajeev , Kumar Viswanathan 
Published: January 2024

AbstractIn antiferroelectrics (AFE), the recovery of AFE phase from field‐induced ferroelectric (FEIN) phase occurs at the depolarization temperature, Td. In this study, we report an exceptionally high pyroelectric coefficient, p ≈ 16.00 × 10−2 C/m2 K at ∼70°C in the AFE composition Pb0.982La0.012(Zr0.60Sn0.30Ti0.10)O3 which lies close to FE‐AFE phase boundary. We closely examine this FEIN‐AFE transformation in virgin and poled samples, during heating, by temperature‐dependent X‐ray diffraction, polarization, strain–electric field hysteresis, dielectric and pyroelectric studies and report, for the first time, the mechanism responsible for this behavior.
Physical distancing during the COVID‐19 crisis: The roles of threat and moralization
Authors: Versteegt Lisanne , van Dijke Marius , van den Bos Kees 
Published: January 2024

AbstractOne reason why the COVID‐19 pandemic presented a challenge to public health is that individuals struggled to adhere to virus protective behaviors, such as physical distancing. To aid understanding why people engaged in distancing practices, we investigated the role of threat perceptions and the moralization of physical distancing. We collected longitudinal data from 340 US citizens across five measurement waves from April 2020 to June 2021. Results showed that individuals who perceived COVID‐19 as more threatening, and those who more strongly moralized physical distancing, were more likely to engage in physical distancing behavior. Moreover, the effect of threat perceptions on physical distancing behavior was mediated by moralization of physical distancing. These results provide new insights into the adherence to physical distancing behaviors during pandemics and underscore the importance of moralization in shaping behavior.
Arrestin beta‐2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix
Authors: Feng Meiting , Wang Ruiling , Deng Li , Yang Yanan , Xia Siying , Liu Feng , Luo Lijun 
Published: January 2024

AbstractAimTo investigate the specific role of arrestin beta‐2 (ARRB2) in the progression of periodontitis and the underlying mechanisms.Materials and MethodsSingle‐cell RNA sequencing data were used to analyse gene expression in periodontal tissues from healthy controls and patients with periodontitis. Real‐time quantitative polymerase chain reaction, Western blotting and immunohistochemical staining were performed to detect the expression of ARRB2. Furthermore, a ligature‐induced periodontitis model was created. Using radiographic and histological methods, RNA sequencing and luciferase assay, the role of ARRB2 in periodontitis and the underlying mechanisms were explored. Finally, the therapeutic effect of melatonin, an inhibitor of activating transcription factor 6 (ATF6), on periodontitis in mice was assessed in both in vivo and in vitro experiments.ResultsARRB2 expression was up‐regulated in inflammatory periodontal tissue. In the ligature‐induced mouse model, Arrb2 knockout exacerbated alveolar bone loss (ABL) and extracellular matrix (ECM) degradation. ARRB2 exerted a negative regulatory effect on ATF6, an essential targeted gene. Melatonin ameliorated ABL and an imbalance in ECM remodelling in Arrb2‐deficient periodontitis mice.ConclusionsARRB2 mediates ECM remodelling via inhibition of the ATF6 signalling pathway, which ultimately exerts a protective effect on periodontal tissues.
Immunoglobulin heavy constant gamma 1 silencing decreases tonicity‐responsive enhancer‐binding protein expression to alleviate diabetic nephropathy
Authors: Hu Qibo , Yang Qingxiao , Gao Hang , Tian Jing , Che Guanghua 
Published: January 2024

AbstractAims/IntroductionThe molecular mechanisms of diabetic nephropathy (DN) are poorly identified. However, the advantage of an increasing amount on microarray data of diabetic nephropathy intrigued us to explore the mechanisms based on bioinformatics prediction for diabetic nephropathy.Materials and MethodsBioinformatics analysis was conducted to screen the hub genes associated with diabetic nephropathy. The average human renal tubular epithelial cells were exposed to high glucose (HG) to generate an in vitro cell model. In addition, a mouse model of diabetic nephropathy was established using a high‐fat diet and streptozotocin injection. Finally, the shRNA targeting immunoglobulin heavy constant gamma 1 (IGHG1) was introduced in vitro and in vivo to illustrate its effect on downstream factors and on the development diabetic nephropathy.ResultsBioinformatics analysis revealed that IGHG1, TRIM11 (tripartite motif protein 11), and TonEBP are highly expressed in diabetic nephropathy. In vitro cell experiments demonstrated that IGHG1 positively regulates the expression of TRIM11 and TonEBP (tonicity‐responsive enhancer binding protein) in HK2 cells treated with high glucose. Furthermore, TRIM11 upregulates the expression of TonEBP through activation of the MEK/ERK (mitogen‐activated protein kinase/extracellular signal‐regulated kinase) signaling pathway in HK2 cells treated with high glucose. In vivo, animal experiments further confirmed that silencing IGHG1 could prevent the occurrence and development of diabetic nephropathy.ConclusionThe silencing of IGHG1 alleviated diabetic nephropathy by inhibiting the TRIM11/MEK/ERK axis and by downregulating TonEBP.