bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Janus Textile with Tunable Heating Modes toward Precise Personal Thermal Management in Cold Conditions
Authors: Tang Litao , Lyu Bin , Gao Dangge , Jia Zhangting , Fu Yatong , Ma Jianzhong 
Published: November 2023

AbstractPassive heating textiles (PHTs) have drawn increasing attention due to the advantages of energy‐conservation heating. However, the heating capabilities of current PHTs are typically static and non‐tunable, presenting poor adaptation to dynamic winter. Herein, a novel Janus textile with tunable heating modes is developed by constructing a customized structure with asymmetric optical properties. This Janus textile is created by coating one side of a cotton fabric with silver nanowires (AgNWs) and then applying transition metal carbides/nitrides (MXene) to the other side. The MXene side exhibits high solar absorptivity and low mid‐infrared emissivity, while the AgNWs side has moderate solar absorptivity and mid‐infrared emissivity. This structure ensures that the solar and radiative heating temperatures of the MXene side are 16 °C and 1.7 °C higher than those of the AgNWs side. This distinction allows for on‐demand, accurate adjustments in solar and radiative heating capabilities by flipping the textile according to ambient temperature. Furthermore, this innovative design also features desired electric heating, thermal camouflage, self‐cleaning and antibacterial properties, electromagnetic interference shielding, durability, and wearability. The Janus textile enables precise thermoregulation of the human body to adapt to variable cold weather, making it essential for optimal personal thermal management and climate change mitigation.
Facilitating Near‐Infrared Persistent Luminescence in Cr3+‐Doped Gadolinium Gallium Garnets
Authors: Wang Xiaomeng , Du Jiaren , Lin Hengwei 
Published: November 2023

AbstractNear‐infrared persistent luminescence (NIR PersL) materials provide great potential in the fields of night vision, biological imaging, and information encryption. However, among various crystal structures, Cr3+‐doped gallium garnets show inferior PersL property, which turns out to be the bottleneck of their versatile applications. The rational design and facile preparation of high‐performance NIR PersL materials are crucial for the emerging applications. In this work, a series of Gd3MgxGexGa5‐2xO12:Cr3+ (x = 0, 0.25, 0.5, 0.75, 1) is investigated by microwave‐assisted solid‐state (MASS) approach. Furthermore, by employing chemical composition co‐substitution, PersL performance is further improved and the optimum working temperature is adjusted to the lower temperature at 10 °C. Trap level distribution of Gd3Mg0.5Ge0.5Ga4O12:Cr3+ phosphor is revealed based on the temperature and fading‐time dependent PersL and thermoluminescence property. Further study demonstrates the reduction of the bandgap and the trap distribution forwards at shallow‐lying trap energy levels. The synergistic effect, from both energy‐band manipulation and trap‐level optimization, facilitates NIR PersL in Cr3+‐doped gadolinium gallium garnets. These findings confirm the applicability of MASS‐based bandgap and defect level engineering for improving the PersL properties in non/inferior‐PersL materials. This burgeoning MASS method may facilitate a wide range of PersL materials for various emerging applications.
Unveiling Atomic‐Scale Product Selectivity at the Cocatalyst‐TiO2 Interface Using X‐Ray Techniques: Insights into Interface Reactivity
Authors: Liu Yin , Li Hanqi , Han Rong , Ouyang Qin , Guo Yuzheng , Zhang Zhaofu , Mu Linqin , Sainio Sami , Nordlund Dennis , Zan Ling , Jiang Zhuo 
Published: November 2023

AbstractThe microstructure at the interface between the cocatalyst and semiconductor plays a vital role in concentrating photo‐induced carriers and reactants. However, observing the atomic arrangement of this interface directly using an electron microscope is challenging due to the coverings of the semiconductor and cocatalyst. To address this, multiple metal‐semiconductor interfaces on three TiO2 crystal facets (M/TiO2─N, where M represents Ag, Au, and Pt, and N represents the 001, 010, and 101 single crystal facets). The identical surface atomic configuration of the TiO2 facets allowed us to investigate the evolution of the microstructure within these constructs using spectroscopies and DFT calculations. For the first time, they observed the transformation of saturated Ti6c─O bonds into unsaturated Ti5c─O and Ti6c─O─Pt bonds on the TiO2─010 facet after loading Pt. This transformation have a direct impact on the selectivity of the resulting products, leading to the generation of CO and CH4 at the Ti6c─O─Pt and Pt sites, respectively. These findings pinpoint the pivotal roles played by the atomic arrangement at the M/TiO2─N interfaces and provide valuable insights for the development of new methodologies using conventional lab‐grade equipment.
Unveiling the Biologically Dynamic Degradation of Iron Oxide Nanoparticles via a Continuous Flow System
Authors: Yang Zhe , Wu Shuwang , Gao Yun , Kou Dandan , Lu Kuan , Chen Can , Zhou Yi , Zhou Dandan , Chen Lei , Ge Jianxian , Li Cang , Zeng Jianfeng , Gao Mingyuan 
Published: November 2023

AbstractNanomaterials are increasingly being employed for biomedical applications, necessitating a comprehensive understanding of their degradation behavior and potential toxicity in the biological environment. This study utilizes a continuous flow system to simulate the biologically relevant degradation conditions and investigate the effects of pH, protein, redox species, and chelation ligand on the degradation of iron oxide nanoparticles. The morphology, aggregation state, and relaxivity of iron oxide nanoparticles after degradation are systematically characterized. The results reveal that the iron oxide nanoparticles degrade at a significantly higher rate under the acidic environment. Moreover, incubation with bovine serum albumin enhances the stability and decreases the dissolution rate of iron oxide nanoparticles. In contrast, glutathione accelerates the degradation of iron oxide nanoparticles, while the presence of sodium citrate leads to the fastest degradation. This study reveals that iron oxide nanoparticles undergo degradation through various mechanisms in different biological microenvironments. Furthermore, the dissolution and aggregation of iron oxide nanoparticles during degradation significantly impact their relaxivity, which has implications for their efficacy as magnetic resonance imaging contrast agents in vivo. The results provide valuable insights for assessing biosafety and bridge the gap between fundamental research and clinical applications of iron oxide nanoparticles.
MXene‐enhanced environmentally stable organohydrogel ionic diode toward harvesting ultralow‐frequency mechanical energy and moisture energy
Authors: Yin Jianyu , Liu Nishuang , Jia Peixue , Ren Ziqi , Zhang Qixiang , Lu Wenzhong , Yao Qianqian , Deng Mingfang , Gao Yihua 
Published: November 2023

AbstractWith the accelerating advancement of distributed sensors and portable electronic devices in the era of big data, harvesting energy from the surrounding environment to power electrical devices has become increasingly attractive. However, most mechanical energy harvesters often require high operating frequencies to function properly. Moreover, for practical applications, the survivability of devices in harsh operating environments is a vital issue which must be addressed. Besides, the single‐stimulus responsiveness limits their further applications in complex external environments. Here, a pressure and moisture dual‐responsive ionic diode consisting of two organohydrogels with opposite charges as an energy harvester is proposed. The organohydrogel ionic diode utilizes the migration of cations and anions to form the depletion zone and followed by an enhancement of the built‐in potential along the depletion zone as a result of mechanical stress or humidity, converting ultralow‐frequency mechanical energy or moisture energy into electrical energy. Meanwhile, this mechanism is further confirmed by the finite element analysis. With the increased rectification ratio due to the introduction of MXene, the ionic diode exhibits a relatively large output current (∼10.10 μA cm−2) and power density (∼0.10 μW cm−2) at a mechanical pressure of 0.01 Hz, outperforming most currently available mechanical energy harvesters. More impressively, the incorporation of ethylene glycol provides the hydrogel ionic diode with excellent temperature tolerance and long‐term environmental stability. The organohydrogel ionic diode can also be applied as a moisture‐driven power generator and self‐powered humidity sensor. This study presents promising prospects for the efficient collection of renewable and sustainable energy and the practical application of hydrogel‐based energy harvesters in extreme environments.
MicroRNA‐140‐3p inhibits proliferation and promotes apoptosis in non‐small cell lung cancer by targeting MDIG
Authors: Yu Miaomiao , Fan Yueren , Zhao Yihang , Tang Yu 
Published: November 2023

AbstractBackgroundMicroRNAs (miRNAs) are associated with cancer progression. MiR‐140‐3p is a tumor suppressor. Nevertheless, its function in non‐small cell lung cancer (NSCLC) is unclear.MethodsMiR‐140‐3p expression in NSCLC clinical specimens was examined using the TCGA database and real‐time PCR. NSCLC cell proliferation and apoptosis were investigated after the miRNA overexpression. Then, mineral dust‐induced gene (MDIG) levels in NSCLC clinical specimens were monitored by real‐time PCR and western blotting. Bioinformatics predicated the binding of miR‐140‐3p to MDIG, and their relationship was validated by luciferase reporter assay. The miR‐140‐3p/MDIG axis was further validated through rescue experiments. The involvement of STAT3 signaling in the actions of miR‐140‐3p/MDIG axis was investigated.ResultsMiR‐140‐3p was decreased in NSCLC tissues and negatively correlated with MDIG expression. Additionally, it was also lower in high‐grade specimens than in low‐grade ones. MiR‐140‐3p restrained cell proliferation, facilitated apoptosis, and inhibited STAT3 signaling in NSCLC. Interestingly, MDIG was a target of this miRNA. Furthermore, MDIG upregulation abolished miR‐140‐3p's effect on cell proliferation, apoptosis, and STAT3 pathway in NSCLC cells.ConclusionMiR‐140‐3p restrained NSCLC development through the regulation of the STAT3 pathway by targeting MDIG. This axis may be a promising target for NSCLC treatment.
Jellyfish: A modular code for wave function‐based electron dynamics simulations and visualizations on traditional and quantum compute architectures
Authors: Langkabel Fabian , Krause Pascal , Bande Annika 
Published: November 2023

AbstractUltrafast electron dynamics have made rapid progress in the last few years. With Jellyfish, we now introduce a program suite that enables to perform the entire workflow of an electron‐dynamics simulation. The modular program architecture offers a flexible combination of different propagators, Hamiltonians, basis sets, and more. Jellyfish can be operated by a graphical user interface, which makes it easy to get started for nonspecialist users and gives experienced users a clear overview of the entire functionality. The temporal evolution of a wave function can currently be executed in the time‐dependent configuration interaction method (TDCI) formalism, however, a plugin system facilitates the expansion to other methods and tools without requiring in‐depth knowledge of the program. Currently developed plugins allow to include results from conventional electronic structure calculations as well as the usage and extension of quantum‐compute algorithms for electron dynamics. We present the capabilities of Jellyfish on three examples to showcase the simulation and analysis of light‐driven correlated electron dynamics. The implemented visualization of various densities enables an efficient and detailed analysis for the long‐standing quest of the electron–hole pair formation.This article is categorized under:
Theoretical and Physical Chemistry > Spectroscopy
Software > Simulation Methods
Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events
Authors: Collart Martine A. , Audebert Léna , Bushell Martin 
Published: November 2023

AbstractThe Ccr4‐Not complex is a global regulator of mRNA metabolism in eukaryotic cells that is most well‐known to repress gene expression. Delivery of the complex to mRNAs through a multitude of distinct mechanisms accelerates their decay, yet Ccr4‐Not also plays an important role in co‐translational processes, such as co‐translational association of proteins and delivery of translating mRNAs to organelles. The recent structure of Not5 interacting with the translated ribosome has brought to light that embedded information within the codon sequence can be monitored by recruitment of the Ccr4‐Not complex to elongating ribosomes. Thereby, the Ccr4‐Not complex is empowered with regulatory decisions determining the fate of proteins being synthesized and their encoding mRNAs. This review will focus on the roles of the complex in translation and dynamics of co‐translation events.This article is categorized under:
Translation > Mechanisms
Translation > Regulation
Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
Authors: Santhosh Kumar Harshitha , Moore James , Steiner Adrian C. , Sotirakis Emmanuel , Schärli Benjamin , Isnard-Petit Patricia , Thiam Kader , Wolfer David P. , Böttger Erik C. 
Published: November 2023

AbstractA common perception in age-related neurodegenerative diseases posits that a decline in proteostasis is key to the accumulation of neuropathogenic proteins, such as amyloid beta (Aβ), and the development of sporadic Alzheimer’s disease (AD). To experimentally challenge the role of protein homeostasis in the accumulation of Alzheimer’s associated protein Aβ and levels of associated Tau phosphorylation, we disturbed proteostasis in single APP knock-in mouse models of AD building upon Rps9 D95N, a recently identified mammalian ram mutation which confers heightened levels of error-prone translation together with an increased propensity for random protein aggregation and which is associated with accelerated aging. We crossed the Rps9 D95N mutation into knock-in mice expressing humanized Aβ with different combinations of pathogenic mutations (wild-type, NL, NL-F, NL-G-F) causing a stepwise and quantifiable allele-dependent increase in the development of Aβ accumulation, levels of phosphorylated Tau, and neuropathology. Surprisingly, the misfolding-prone environment of the Rps9 D95N ram mutation did not affect Aβ accumulation and plaque formation, nor the level of phosphorylated Tau in any of the humanized APP knock-in lines. Our findings indicate that a misfolding-prone environment induced by error-prone translation with its inherent perturbations in protein homeostasis has little impact on the accumulation of pathogenic Aβ, plaque formation and associated phosphorylated Tau.
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
Authors: Agoitia Andrés , Cruz-Sanchez Apolinar , Balderas Israela , Bermúdez-Rattoni Federico 
Published: November 2023

Abstract
Rationale
Relapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seeking depends on the duration of abstinence, a phenomenon known as the incubation of drug craving. Clinical and preclinical research shows that the insular cortex is involved in substance use disorders and cue-induced drug seeking. However, the role of the insula on memory retrieval and motivational integration for cue-elicited drug seeking remains to be determined.

Objectives
We investigated the role of the anterior insular cortex (aIC) and its glutamatergic projection to amygdala nuclei (aIC-AMY) on the expression of conditioned place preference (CPP) during early and late abstinence.

Methods
Male adult C57BL/6J mice underwent amphetamine-induced CPP, and their preference was tested following 1 or 14 days of abstinence. aIC and aIC-AMY functional role in CPP expression was assessed at both abstinence periods by employing optogenetic silencing and behavioral pharmacology.

Results
Compared to a single day, an exacerbated preference for the amphetamine-paired context was observed after 14 days of abstinence. Photoinhibition of either aIC or aIC-AMY projection reduced CPP expression following late but not early abstinence. Similarly, the antagonism of aIC NMDA receptors reduced CPP expression after 14 days of abstinence but not 1 day.

Conclusions
These results suggest that aIC and its glutamatergic output to amygdala nuclei constitute critical neurobiological substrates mediating enhanced motivational cue reactivity during the incubation of amphetamine craving rather than contextual memory recall. Moreover, cortical NMDA receptor signaling may become sensitized during abstinence, ultimately modulating disproportioned drug seeking.
Refining accuracy of RV–PA coupling in patients undergoing transcatheter tricuspid valve treatment
Authors: Sugiura Atsushi , Tanaka Tetsu , Kavsur Refik , Öztürk Can , Silaschi Miriam , Goto Tadahiro , Weber Marcel , Zimmer Sebastian , Nickenig Georg , Vogelhuber Johanna 
Published: November 2023

Abstract
Background
Assessing right ventricular (RV) function is paramount for risk stratification, which remains challenging in patients with tricuspid regurgitation (TR). We assessed RV–pulmonary artery (PA) coupling and its predictability of outcomes after transcatheter tricuspid valve repair (TTVR).

Methods
Study participants comprised patients undergoing transcatheter tricuspid valve repair to treat symptomatic TR from June 2015 to July 2021. We calculated an RV–PA coupling ratio using a formula, which is dividing tricuspid annular plane systolic excursion (TAPSE) by echocardiographically estimated (ePASP) or invasively measured PASP (iPASP) at baseline. The primary outcome was all-cause mortality or heart failure rehospitalization within one year.

Results
The study participants (n = 206) were at high surgical risk (EuroSCORE II: 7.4 ± 4.8%). The primary outcome occurred in 57 patients within one year. The c-statistics for the outcome were 0.565 (95% CI 0.488–0.643) for TAPSE/ePASP and 0.695 (95% CI 0.631–0.759) for TAPSE/iPASP. The correlation between the ePASP and iPASP was attenuated in patients with massive/torrential TR compared to those with severe TR (interaction p = 0.01). In the multivariable Cox proportional model, TAPSE/iPASP was inversely associated with the risk of the primary outcome (per 0.1-point increase: adjusted-HR 0.67, 95% CI 0.56–0.82, p < 0.001), independent of baseline demographics. According to the TAPSE/iPASP quartiles (i.e., ≤ 0.316; 0.317–0.407; 0.408–0.526; ≥ 0.527), the event-free survival was 43.4%, 48.3%, 77.9%, and 85.4% at one year after TTVR.

Conclusion
RV–PA coupling predicts one-year mortality and heart failure rehospitalization after TTVR in patients with TR. The predictability is improved if invasively-measured PA pressure is included.

Graphical abstract
Assessing right ventricular (RV) function is paramount for risk stratification. The present analysis confirms that RV–PA coupling, measured as TAPSE/PASP, predicts one-year mortality and heart failure rehospitalization in patients undergoing TTVR. There is a significant interaction between TR severity and the correlation of ePASP with iPASP, and therefore the correlation is attenuated in patients with massive to torrential TR. The predictability of RV–PA coupling is improved if PA pressure is measured invasively and included in the formula.
SNP array genomic analysis of matched pairs of brain and liver metastases in primary colorectal cancer
Authors: Brandt Vivian-Pascal , Holland Heidrun , Wallenborn Marco , Koschny Ronald , Frydrychowicz Clara , Richter Mandy , Holland Lydia , Nestler Ulf , Sander Caroline 
Published: November 2023

Abstract
Purpose
Brain metastasis formation is a rare and late event in colorectal cancer (CRC) patients and associated with poor survival. In contrast to other metastatic sites, the knowledge on chromosomal aberrations in brain metastases is very limited.

Methods
Therefore, we carried out single nucleotide polymorphism (SNP) array analyses on matched primary CRC and brain metastases of four patients as well as on liver metastases of three patients.

Results
Brain metastases showed more chromosomal aberrations than primary tumors or liver metastases. Commonly occurring aberrations were gain of 8q11.1-q24.3 (primary CRC), gain of 13q12.13-q12.3 (liver metastases), and gain of 20q11.1-q13.33 (brain metastases). Furthermore, we found one copy-neutral loss of heterozygosity (cn-LOH) region on chromosome 3 in primary CRC, three cn-LOH regions in liver metastases and 23 cn-LOH regions in brain metastases, comprising 26 previously undescribed sites.

Conclusion
The more frequent occurrence of cn-LOHs and subsequently affected genes in brain metastases shed light on the pathophysiology of brain metastasis formation. Further pairwise genetic analyses between primary tumors and their metastases will help to define the role of affected genes in cn-LOH regions.
Complexity Issues on of Secondary Domination Number
Authors: Raczek Joanna 
Published: November 2023

AbstractIn this paper we study the computational complexity issues of the problem of secondary domination (known also as (1, 2)-domination) in several graph classes. We also study the computational complexity of the problem of determining whether the domination and secondary domination numbers are equal. In particular, we study the influence of triangles and vertices of degree 1 on these numbers. Also, an optimal algorithm for finding a minimum secondary dominating set in trees is presented.