bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex determination by ultrasonography prior to artificial breeding of the pufferfish Arothron manilensis (Tetraodontiformes, Tetraodontidae)
Authors: Doi Hiroyuki , Murakami Shoki , Momota Kazuyuki , Obata Hiroshi , Sakai Harumi 
Published: January 2024

AbstractArtificial breeding was induced in the pufferfish Arothron manilensis following ultrasonographic sex determination. Hormonal treatment of mature male and female specimens followed the collection (and measurement) of fully developed eggs by cannulation. Fertilized eggs (0.85 ± 0.02 mm diameter) were spherical, demersal and individually adhesive. Hatching occurred 5 days after fertilization, larvae being 2.23 ± 0.15 mm in total length and 2.08 ± 0.14 mm in notochord length. The larvae had all died within 14 days of hatching. To improve artificial breeding techniques for A. manilensis, it is necessary to determine more appropriate timing for hormone injection, as well as feeding nutrient‐enhanced SS type Brachionus sp. to newly hatched larvae.
Interpretable Structural Analysis for Evolutionary Generative Design of Coastal Breakwaters
Authors: Sidorenko Denis O. , Starodubcev Nikita O. , Pinchuk Maiia , Nikitin Nikolay O. 
Published: January 2024

AbstractThis paper presents an interpretable approach for the generative design of coastal breakwaters that combines evolutionary optimization and structural analysis of solutions. It allows both to improve the convergence of optimization for breakwaters structure and analyze the sensitivity of each sub-part of the solution to various changes. We conduct experiments on synthetic harbour configuration to validate this approach. The results confirm the effectiveness of our method in generating high-quality and explainable breakwater designs.
New insights into the genetics of mandibular retrognathism: novel candidate genes
Authors: Paddenberg-Schubert Eva , Küchler Erika , Bitencourt Reis Caio Luiz , Silva-Sousa Alice Corrêa , Kirschneck Christian 
Published: January 2024

Abstract
Purpose
Mandibular retrognathism (MR) is a common skeletal malocclusion in humans with a strong genetic component. Single nucleotide polymorphisms (SNPs) in genes encoding epidermal growth factor (EGF) and EGF receptor (EGFR) could be involved in the etiology of mandibular retrognathism. Therefore, in this study, we investigated whether SNPs in the genes encoding for EGF and EGFR are associated with MR in German teenagers.

Methods
This nested case–control study evaluated German orthodontic patients, aged 10–18 years. DNA, which was isolated from buccal epithelial cells using two cytobrushes, was used for genotyping analysis and digital pretreatment lateral cephalograms were examined to calculate SNB and ANB. Patients with a retrognathic mandible (SNB < 78°) were included as cases, while patients with an orthognathic mandible (SNB = 78–82°) were included as controls. Four SNPs in the genes encoding for EGF and EGFR were chosen and genotyped using real-time PCR. Allele, genotype, and haplotype frequency were compared across groups (α = 5%).

Results
Finally, 119 patients were included in this study (45 orthognathic mandible, 74 retrognathic mandible). The minor allele G in rs4444903 (EGF) was statistically more frequent in individuals with an orthognathic mandible (p = 0.008). The haplotype formed by the mutant alleles for rs4444903|rs2237051 (EGF; G|A) was statistically more frequent in the orthognathic mandible group (p = 0.007). The SNPs rs4444903 and rs2237051 in EGF, and rs2227983 in EGFR were statistically associated with a decreasing risk of developing a retrognathic mandible according to univariate and multivariate statistical analysis (p < 0.05).

Conclusion
SNPs in EGF (rs4444903 and rs2237051) and EGFR (rs2227983) were associated with MR in our German sample and could be genetic biomarkers for early and individualized diagnostic identification of retrognathic mandibular development by means of genetic screening tests.
Regressive versions of Hindman’s theorem
Authors: Carlucci Lorenzo , Mainardi Leonardo 
Published: January 2024

AbstractWhen the Canonical Ramsey’s Theorem by Erdős and Rado is applied to regressive functions, one obtains the Regressive Ramsey’s Theorem by Kanamori and McAloon. Taylor proved a “canonical” version of Hindman’s Theorem, analogous to the Canonical Ramsey’s Theorem. We introduce the restriction of Taylor’s Canonical Hindman’s Theorem to a subclass of the regressive functions, the $$\lambda $$
λ
-regressive functions, relative to an adequate version of min-homogeneity and prove some results about the Reverse Mathematics of this Regressive Hindman’s Theorem and of natural restrictions of it. In particular we prove that the first non-trivial restriction of the principle is equivalent to Arithmetical Comprehension. We furthermore prove that the well-ordering-preservation principle for base-$$\omega $$
ω
exponentiation is reducible to this same principle by a uniform computable reduction.
Stefin B alleviates the gouty arthritis in mice by inducing the M2 polarization of macrophages
Authors: Lin Shishui , Hu Xu , Li Yang , Huang Jiyue , Zhang Rui , Bai Xinxin , Weng Shaohuang , Chen Min 
Published: January 2024

AbstractThe present study aims to explore the therapeutic effect of Stefin B on gouty arthritis (GA) and the polarization of macrophages in mice. Stefin B-overexpressed or knockdown M0 macrophages were constructed. The GA model was established in mice by injecting 25 mg/mL MSU, followed by a single injecting of Stefin B-overexpressing adenovirus vector (GA model + Stefin B OE) or an empty vector (GA model + Stefin B OE NC). Stefin B was found lowly expressed in M1 macrophages. CD206 was markedly upregulated and IL-10 release was signally increased in Stefin B-overexpressed macrophages. In gouty arthritis mice, marked redness and swelling were observed in the ankle joint. Dramatical infiltration of inflammatory cells was observed in the GA model and GA model + Stefin B OE NC groups, which was suppressed in the Stefin B OE group. Increased proportion of F4/80+CD86+ cells observed in GA mice was markedly repressed by Stefin B overexpression, accompanied by the declined level of Caspase-1 and IL-17. Collectively, Stefin B alleviated the GA in mice by inducing the M2 polarization of macrophages.
Pulmonary lesions in early response assessment in pediatric Hodgkin lymphoma: prevalence and possible implications for initial staging
Authors: Stoevesandt Dietrich , Ludwig Christiane , Mauz-Körholz Christine , Körholz Dieter , Hasenclever Dirk , McCarten Kathleen , Flerlage Jamie E. , Kurch Lars , Wohlgemuth Walter A. , Landman-Parker Judith , Wallace William H. , Fosså Alexander , Vordermark Dirk , Karlén Jonas , Cepelová Michaela , Klekawka Tomasz , Attarbaschi Andishe , Hraskova Andrea , Uyttebroeck Anne , Beishuizen Auke , Dieckmann Karin , Leblanc Thierry , Daw Stephen , Steglich Jonas 
Published: January 2024

Abstract
Background
Disseminated pulmonary involvement in pediatric Hodgkin lymphoma (pHL) is indicative of Ann Arbor stage IV disease. During staging, it is necessary to assess for coexistence of non-malignant lung lesions due to infection representing background noise to avoid erroneously upstaging with therapy intensification.

Objective
This study attempts to describe new lung lesions detected on interim staging computed tomography (CT) scans after two cycles of vincristine, etoposide, prednisolone, doxorubicin in a prospective clinical trial. Based on the hypothesis that these new lung lesions are not part of the underlying malignancy but are epiphenomena, the aim is to analyze their size, number, and pattern to help distinguish true lung metastases from benign lung lesions on initial staging.

Materials and methods
A retrospective analysis of the EuroNet-PHL-C1 trial re-evaluated the staging and interim lung CT scans of 1,300 pediatric patients with HL. Newly developed lung lesions during chemotherapy were classified according to the current Fleischner glossary of terms for thoracic imaging. Patients with new lung lesions found at early response assessment (ERA) were additionally assessed and compared to response seen in hilar and mediastinal lymph nodes.

Results
Of 1,300 patients at ERA, 119 (9.2%) had new pulmonary lesions not originally detectable at diagnosis. The phenomenon occurred regardless of initial lung involvement or whether a patient relapsed. In the latter group, new lung lesions on ERA regressed by the time of relapse staging. New lung lesions on ERA in patients without relapse were detected in 102 (7.8%) patients. Pulmonary nodules were recorded in 72 (5.5%) patients, the majority (97%) being<10 mm. Consolidations, ground-glass opacities, and parenchymal bands were less common.

Conclusion
New nodules on interim staging are common, mostly measure less than 10 mm in diameter and usually require no further action because they are most likely non-malignant. Since it must be assumed that benign and malignant lung lesions coexist on initial staging, this benign background noise needs to be distinguished from lung metastases to avoid upstaging to stage IV disease. Raising the cut-off size for lung nodules to ≥ 10 mm might achieve the reduction of overtreatment but needs to be further evaluated with survival data. In contrast to the staging criteria of EuroNet-PHL-C1 and C2, our data suggest that the number of lesions present at initial staging may be less important.
Autoantikörperdiagnostik bei idiopathisch inflammatorischen Myopathien
Authors: Biesen Robert , Schneider Udo , Lindae Antje , Mierau Rudolf 
Published: January 2024

ZusammenfassungIdiopathische inflammatorische Myopathien (IIM) sind eine Gruppe seltener und heterogener Systemerkrankungen, die sich nicht nur an der Muskulatur, sondern auch an der Haut, den Gelenken und der Lunge manifestieren. Die Erstsymptome können isoliert und variabel auftreten, und so stellt die Diagnosefindung verschiedene Fachgruppen vor Herausforderungen. Da Autoantikörper mitunter die einzigen spezifischen Befunde sind, die zur Diagnose und einer angepassten Therapie führen, sind grundlegende Kenntnisse über diese unabdingbar. In dieser Arbeit erklären wir verfügbare Testsysteme, benennen die klinischen notwendigen Indikationen zur Veranlassung einer Autoantikörperdiagnostik, geben Informationen zu Etymologie, Antigenen, Synonymen und Erstbeschreibern, beschreiben die durch Myositisantikörper induzierte indirekte Immunfluoreszenz auf HEp-2-Zellen und geben die klinisch-serologischen Assoziationen wieder. Der Abgleich des Autoantikörperbefundes mit der klinischen Symptomatik und laborchemischen Befunden ermöglicht im Sinne einer Plausibilitätsprüfung, falsch positive oder auch falsch negative Laborbefunde zu identifizieren.
Reconstruction of rock avalanche history in Val Viola, (Upper Valtellina, Italian Central Alps) through 10Be exposure ages, Schmidt Hammer R values, and surface roughness
Authors: Longhi Alessandro , Morgan Daniel , Guglielmin Mauro 
Published: January 2024

AbstractWe investigated the paraglacial evolution and permafrost degradation of Val Viola (Upper Valtellina, Central Italian Alps) through a geomorphologic survey, cosmogenic dating, Schmidt’s Hammer, and surface roughness measurements. Our results reveal that the previously mapped Val Viola rock avalanche is probably derived by three different events that occurred 7.7 ± 0.2 ka (Orthogneiss_ 1), 7.0 ± 0.2 ka (Paragneiss), and 5.0 ± 0.3 ka (Orthogneiss_2). Because the main valley bottom has been ice free since at least 12.6 ka, it is unlikely that the triggering factor of these events was the debutressing stress caused by the melting of local valley glaciers. Therefore, permafrost that formed in this area down to 2525 m a.s.l. at 9.3–8 ka and degraded successively between 7.8 and 6.5 ka was likely the main triggering factor of the first two rock avalanche events, as well as for the third event that happened during the warm and wet period of the Holocene Thermal Maximum around 5 ka.
A novel triple periodic minimal surface-like plate lattice and its data-driven optimization method for superior mechanical properties
Authors: Wang Yanda , Lian Yanping , Wang Zhidong , Wang Chunpeng , Fang Daining 
Published: January 2024

AbstractLattice structures can be designed to achieve unique mechanical properties and have attracted increasing attention for applications in high-end industrial equipment, along with the advances in additive manufacturing (AM) technologies. In this work, a novel design of plate lattice structures described by a parametric model is proposed to enrich the design space of plate lattice structures with high connectivity suitable for AM processes. The parametric model takes the basic unit of the triple periodic minimal surface (TPMS) lattice as a skeleton and adopts a set of generation parameters to determine the plate lattice structure with different topologies, which takes the advantages of both plate lattices for superior specific mechanical properties and TPMS lattices for high connectivity, and therefore is referred to as a TPMS-like plate lattice (TLPL). Furthermore, a data-driven shape optimization method is proposed to optimize the TLPL structure for maximum mechanical properties with or without the isotropic constraints. In this method, the genetic algorithm for the optimization is utilized for global search capability, and an artificial neural network (ANN) model for individual fitness estimation is integrated for high efficiency. A set of optimized TLPLs at different relative densities are experimentally validated by the selective laser melting (SLM) fabricated samples. It is confirmed that the optimized TLPLs could achieve elastic isotropy and have superior stiffness over other isotropic lattice structures.
Trastuzumab and first-line taxane chemotherapy in metastatic breast cancer patients with a HER2-negative tumor and HER2-positive circulating tumor cells: a phase II trial
Authors: Verschoor Noortje , Bos Manouk K. , de Kruijff Ingeborg E. , Van Mai N. , Kraan Jaco , Drooger Jan C. , Zuetenhorst Johanna M. , Wilting Saskia M. , Sleijfer Stefan , Jager Agnes , Martens John W. M. 
Published: January 2024

Abstract
Purpose
HER2 overexpressing circulating tumor cells (CTCs) are observed in up to 25% of HER2-negative metastatic breast cancer patients. Since targeted anti-HER2 therapy has drastically improved clinical outcomes of patients with HER2-positive breast cancer, we hypothesized that patients with HER2 overexpressing CTCs might benefit from the addition of trastuzumab to chemotherapy.

Methods
In this single-arm, phase II trial, patients with HER2-positive CTCs received trastuzumab as addition to first-line treatment with taxane chemotherapy. Patients with detectable CTCs but without HER2 overexpression that received taxane chemotherapy only, were used as control group. The primary outcome measure was progression-free rate at 6 months (PFR6), with a target of 80%. In November 2022, the study was terminated early due to slow patient accrual.

Results
63 patients were screened, of which eight patients had HER2-positive CTCs and were treated with trastuzumab. The median number of CTCs was 15 per 7.5 ml of blood (range 1–131) in patients with HER2-positive CTCs, compared to median 5 (range 1–1047) in the control group. PFR6 was 50% in the trastuzumab group and 54% in the taxane monotherapy group, with no significant difference in median PFS (8 versus 9 months, p = 0.51).

Conclusion
No clinical benefit of trastuzumab was observed, although this study was performed in a limited number of patients. Additionally, we observed a strong correlation between the number of evaluable CTCs and the presence of HER2-positive CTCs. We argue that randomized studies investigating agents that are proven to be solely effective in the HER2-positive patient group in patients with HER2-positive CTCs and HER2-negative tissue are currently infeasible. Several factors contribute to this impracticality, including the need for more stringent thresholds, and the rapidly evolving landscape of cancer treatments.
RESTBERTa: a Transformer-based question answering approach for semantic search in Web API documentation
Authors: Kotstein Sebastian , Decker Christian 
Published: January 2024

AbstractTo enable machines to process state-of-practice Web API documentation, we propose a Transformer model for the generic task of identifying a Web API element within a syntax structure that matches a natural language query. We solve this semantic-search task with Transformer-based question answering and demonstrate the applicability of our approach to two different tasks, namely the discovery of endpoints and the identification of parameters in payload schemas. With samples from 2321 OpenAPI documentation, we prepare different datasets and fine-tune pre-trained BERT models to these two tasks. We evaluate the generalizability and the robustness of our fine-tuned models. We achieve accuracies of 81.95% for the parameter-matching and 88.44% for the endpoint-discovery task.
To Nod or Not to Nod: How Does Interviewer Nonverbal Behavior Affect Rapport Perceptions and Recall in Truth Tellers and Lie Tellers?
Authors: Deeb Haneen , Leal Sharon , Vrij Aldert , Mann Samantha , Dabrowna Oliwia 
Published: January 2024

AbstractResearchers have often claimed that the interviewer’s nonverbal behavior such as nodding facilitates rapport building, the number of recalled details, and verbal veracity cues. However, there is no experiment to-date that isolated the effects of nodding in information gathering interviews. We thus examined the effects of interviewer’s nodding behavior on rapport perceptions and on the number and accuracy of total details provided by truth tellers and lie tellers. Participants (N = 150) watched a video recording and then reported it truthfully or falsely to an interviewer. The interviewer showed demeanor that was either supportive with nodding, supportive without nodding, or neutral. Truth tellers reported more total details than lie tellers and these effects were similar across demeanor conditions. No significant effects emerged for rapport perceptions and accuracy of total details. These results suggest that the interviewer’s nodding behavior does not affect rapport perceptions and details provided by truth tellers and lie tellers.
“MAMA’s is like a second mom:” Client and Staff Experiences in a Comprehensive Social Risk Care Management Program Within a Perinatal Medical Home
Authors: Houston Kasee , Arellano Flor , Imany-Shakibai Helia , Jackson Ashaki , Saleeby Erin , Dudovitz Rebecca , Schickedanz Adam 
Published: January 2024

Abstract
Introduction
Addressing persistent racial inequities in preterm birth requires innovative health care approaches. The Los Angeles County Maternity Assessment and Management Access Service Synergy Neighborhood program (MAMA’s) is a perinatal medical home program designed to alleviate the impacts of chronic stress by addressing social determinants of health. It reduced odds of preterm birth rates in Black participants, yet it is unclear which program components most contributed to this reduction. This study seeks to understand the experiences of staff and clients within the MAMA’s program to identify what factors decrease stress, how the program addresses racism and the challenges and opportunities of optimizing health during the COVID-19 pandemic.

Methods
21 staff and 34 clients completed semi-structured interviews from November 2020–December 2021. Separate interview guides for staff and clients explored experiences within the program, experiences during the COVID-19 pandemic, and how racism affects clients. Interviews were recorded and transcribed. Analysis used a phenomenologic framework. Coding was performed using grounded theory to identify themes.

Results
Analysis revealed six key themes: Stressors clients face, barriers for undocumented, Latina, and Spanish-speaking clients, exceptional care, emotional support, naming and responding to racism and discrimination, and impacts of COVID-19 pandemic.

Discussion
Staff and clients work together to address social needs in order to address chronic stress and racism in their lives, especially during the COVID-19 pandemic. Interviews revealed relationship building is a cornerstone of the program’s success and plays a significant role in alleviating chronic stress in this population.
Pituitary hypophysitis in granulomatosis with polyangiitis (GPA): a case series
Authors: Alameri Majid , Alnuaimi Abdulla , Martin Niamh M. , Meeran Karim , Gontsarova Anastasia , Barwick Tara D. , Ellis Spencer , McAdoo Stephen , Tomlinson James , Wernig Florian 
Published: January 2024

AbstractGranulomatosis with polyangiitis (GPA) rarely involves the pituitary gland. Pituitary involvement has been reported in ~ 1% of all cases of GPA. Most commonly, pituitary swelling and inflammation results in symptoms due to pituitary mass effect and arginine vasopressin deficiency. To date, there are no pituitary-specific treatment guidelines for this rare condition. We present three patients with GPA-related hypophysitis highlighting the spectrum of pituitary involvement. All three patients were successfully treated with immunosuppressive regimens that included rituximab (RTX). Following remission induction with high-dose glucocorticoids, patients received 6 monthly RTX for remission maintenance. RTX was well tolerated without significant side effects.
Pragmatist reflective equilibrium
Authors: van der Burg Wibren 
Published: January 2024

AbstractRawls’ notion of reflective equilibrium has a hybrid character. It is embedded in the pragmatist tradition, but also includes various Kantian and other non-pragmatist elements. I argue that we should discard all non-pragmatist elements and develop reflective equilibrium in a consistently pragmatist manner. I argue that this pragmatist approach is the best way to defend reflective equilibrium against various criticisms, partly by embracing the critiques as advantages. I begin with discussing how each of the three versions of reflective equilibrium in Rawls’ work combines pragmatist and non-pragmatist elements. For Rawls, the primary purpose of reflective equilibrium is epistemic: namely, to construct moral theories or judgments. In a pragmatist approach, there are three connected purposes for moral inquiry: right action, reliable understanding and self-improvement. Depending on the specific context of a reflective equilibrium process, these general purposes can give rise to a variety of specific purposes. In the next sections, I develop a pragmatist approach to reflective equilibrium and discuss the implications of this approach for core elements of reflective equilibrium. These elements are: the initial convictions, facts, personal commitments and comprehensive views of life, coherence and additional methods for critical scrutiny.