bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic consequences of climate change impacts on South Asian agriculture: A computable general equilibrium analysis
Authors: Abeysekara Walimuni Chamindri Sewanka Mendis , Siriwardana Mahinda , Meng Samuel 
Published: November 2023

AbstractSouth Asia is one of the most vulnerable regions of the globe in terms of climate change, with agriculture the most affected economic sector of the region. This study employs an environmental Global Trade Analysis Project model to simulate the impact of an average global 2°C temperature increase by 2050, with a focus on South Asian countries. The economic costs of climate change in relation to crop productivity losses due to increasing temperature, land productivity losses caused by rising sea levels and heat stress‐induced agricultural labour productivity losses are assessed based on model simulations. The results show that the unfavourable climate change impacts on agricultural productivity (crop, land and labour) will reduce food production and create upward pressure on food prices. This will lead to a reduction in food consumption at the household level, threatening future food security in the region. The results further predict a contraction in all South Asian economies by 2050, due to adverse climate change impacts on the agricultural sector. In addition, out of the three climate change damage factors considered, labour productivity causes the greatest economic losses, while land productivity losses caused by rising sea levels impact the least. The study also found that low‐income countries would suffer most severely due to the impacts of climate change on the agricultural sector, while high‐income countries would be impacted the least.
Striving for health equity during the COVID‐19 pandemic: Vaccine distribution in DuPage County, IL
Authors: Fifolt Matthew , Hoff Christopher , Lundeen Kristen 
Published: November 2023

AbstractThis article is an example of ‘Lessons from the Field’. The likelihood of future novel diseases, like coronavirus disease 2019 (COVID‐19), is extremely high due to global travel, increased antibiotic resistance, and vaccine hesitancy of common viruses based on attitudes towards the COVID‐19 vaccine. Therefore, local and state health departments should incorporate lessons learned from the COVID‐19 pandemic into their operational planning. At the beginning of the COVID‐19 pandemic, most health departments in Illinois served as direct points‐of‐distribution for dispensing vaccine. The DuPage County Health Department (DCHD), however, chose to distribute vaccine through a hub‐and‐spoke model in which an established network of providers throughout the county administered vaccine based on availability and need. By decentralizing vaccine distribution, DCHD put vaccine in the areas of greatest need while also reducing the burden of transportation for vulnerable populations. Moreover, the hub‐and‐spoke model may have contributed to health equity due to the variety of providers in the network who were trusted among hesitant individuals within the community. By summer 2021, DuPage County ranked in the top 2% of US counties with eligible residents vaccinated against COVID‐19.
Use of a lockable pigtail catheter (Cook Dawson‐Mueller Multipurpose Drainage Catheter) for nephrostomy reduces the risk of slippage of the catheter
Authors: Yajima Shugo , Nakanishi Yasukazu , Hirose Kohei , Kataoka Madoka , Masuda Hitoshi 
Published: November 2023

AbstractObjectiveThis study compared the outcomes of using Mac‐Loc catheters and non–Mac‐Loc catheters for percutaneous nephrostomy (PCN). Mac‐Loc catheters have a locking mechanism that forms a curl at the tip by pulling a suture and securing it in place.MethodologyThis retrospective study compared the outcomes of consecutive patients who received PCN with catheters equipped with Mac‐Loc versus those with catheters without Mac‐Loc. Catheter failure was the primary endpoint of the study and was defined as all cases of catheter malfunction after PCN. A propensity score was calculated from covariates based on clinical variables, and patients in each group were matched 1:1 based on the propensity score.ResultsDuring the follow‐up period, a total of 289 cases underwent PCN, 72 with catheters equipped with Mac‐Loc and 217 without Mac‐Loc. Failure of the catheter occurred in 63 cases (22%). There were 44 cases (70%) of slippage, 18 cases (29%) of obstruction, and 1 case (2%) of catheter rupture. After propensity score matching, catheter failure–free survival was significantly higher in the group with catheters equipped with Mac‐Loc than in the group without Mac‐Loc (P = .003).ConclusionsThe use of catheters equipped with Mac‐Loc for PCN reduces the risk of unintentional catheter slippage.
Insect bioactive compounds and their potential use in animal diets and medicine
Authors: Bingqian Ning , Ali Shah Assar , Matra Maharach , Wanapat Metha , Ullah Khan Rifat , Ahmad Shakoor , Ullah Shakeeb , Shuaib Khan Muhammad , Kamal Shah Muhammad 
Published: November 2023

AbstractThis study examined the effects of various insect species, such as those of Bombyx mori, Hermetia illucens and Tenebrio monitor, that have long been used in combination with medicinal plants and are an important alternative to modern medicine in many parts of the world. The current use of traditional pesticides from around the year 2010 and the characteristics of isolated biologically active molecules are also presented. Natural insect products were examined or isolated from ants, bees, beetles, cockroaches, termites, bees, etc. The biological activities of these natural products derived from insects include antimicrobial, antifungal, anticancer, antiviral, antioxidant and anti‐inflammatory effects. Insect additives to animal feed rarely distort the relevant physicochemical variables or sensory profile of the meat, whereas the fatty acid (FA) profile is discernibly changed. In fact, insect derivatives have great potential for future drug discovery in natural products, as well as for the production of nutritious foods for humans and for animals. It is concluded that the inoculation of insect powder in animal feeds results in the prevention and treatment of disease, enhances the growth of animals and promotes the bioactive compounds in animal‐based products. Owing to the sustainability of their breeding, large‐scale cultures of these insects seem economically viable. Insect oil and protein as well as chitin ingredients are widely used in cosmetics, and these substances are considered high‐value co‐products. The major challenges associated with their use will be linked to the development of methods for separating industrial‐derived materials.
Detection of deformed wing virus in the greenhouse for possible horizontal transmission of virus in honey bee colony
Authors: You Euijin , Moon KyungHwan , Kim Hyemin , Kim Young Ho 
Published: November 2023

AbstractThe honey bee Apis mellifera L. is a crucial insect in the agricultural industry and natural ecosystem by being a major pollinator. Nevertheless, honey bee population has been recently facing a decline. Among the several factors responsible for this decline, deformed wing virus (DWV) is considered a primary cause that negatively affects honey bee health. DWV is a cosmopolitan honey bee pathogen and causes morphological disadvantages in individual honey bees and colony collapse. Regarding the horizontal transmission of DWV, in addition to Varroa destructor, a well‐known major vector of DWV, flowers have recently been implied as a transmission route. Therefore, in this study, we detected DWV from various substances, including flowers, honey bee feces, pupa, larva, nurse bee, surface of nurse bee, pollen collected by forager bee, and forager bee samples in four strawberry greenhouses, which could suggest the potential for the horizontal transmission of DWV in the semi‐field condition. We also detected DWV in pollen collected by DWV‐negative forager bees, implying that flowers can serve as a potential source of virus infection. These findings suggest that the surrounding environment such as shared floral sources affects the spread of DWV.
Small molecule multitarget antiangiogenic inhibitor treatments for advanced thymic epithelial tumors: A retrospective study
Authors: Shen Wanji , Jin Ying , Yu Ying , Chen Ning , Fan Yun 
Published: November 2023

AbstractBackgroundThymic epithelial tumors (TETs) are rare malignant tumors with limited treatment options. No established second‐line treatment regimen is available following the preferred first‐line chemotherapy, resulting in unsatisfactory efficacy and poor prognosis for patients with advanced TETs. This study aimed to evaluate the efficacy of small molecule multitarget antiangiogenic inhibitors as well as the prognostic factors for advanced TETs.MethodsA retrospective study was conducted using data from a real‐world database. Clinical information and survival follow‐up data were collected from 52 patients with advanced TETs who received small molecule multitarget antiangiogenic inhibitors at Zhejiang Cancer Hospital between August 10, 2016 and August 10, 2022. The short‐term efficacy of the treatments, survival time of the patients, and relevant prognostic factors of advanced TETs were analyzed.ResultsOut of the 52 patients included in this study, 16 had thymoma and 36 had thymic carcinoma. The 52 patients had an overall response rate of 21.1% and a disease control rate of 94.2%. In addition, the median progression‐free survival (PFS) was 8.05 months, and the overall survival (OS) was 25.00 months. Apatinib was given to 33 patients, anlotinib to 15 patients, and sunitinib or lenvatinib to four patients. Only seven patients received antiangiogenic inhibitors as their first‐line therapy, 27 patients as their second‐line therapy, and 18 patients as third‐line or subsequent therapy. Meanwhile, 42 patients received monotherapy with an antiangiogenesis inhibitor, while 10 patients received combination therapy. Univariate analysis indicated that the combined treatment was associated with a superior OS (p = 0.044); multivariate analysis indicated that the combined treatment was an independent prognostic factor for PFS (p = 0.014) and OS (p = 0.012).ConclusionThe findings suggest that small molecule multitarget antiangiogenic inhibitors are efficacious as second or post‐line treatments as a viable alternative treatment option for patients with advanced TETs.
Hazardous alcohol consumption and perioperative complications in a cardiac surgery patient. A retrospective study
Authors: Nissilä Eliisa , Suojaranta Raili , Hynninen Marja , Dahlbacka Sebastian , Hästbacka Johanna 
Published: November 2023

AbstractBackgroundWe investigated the prevalence and effects of hazardous alcohol consumption on perioperative complications in cardiac surgery patients. Preoperative hazardous alcohol consumption has been associated with an increased risk of postoperative complications in noncardiac patient populations.MethodsWe retrospectively collected data from the Finnish Intensive Care Consortium database and electronic patient records on all cardiac surgery patients treated in the intensive care units (ICUs) of Helsinki University Hospital (n = 919) during 2017. Data on preoperative alcohol consumption were routinely collected using the alcohol use disorder identification test consumption (AUDIT‐C) questionnaire. We analyzed perioperative data and outcomes for any associations with hazardous alcohol consumption. Outcome measures were length of stay in the ICU, re‐admissions to ICU, bleeding and infectious complications, and incidence of postoperative arrhythmias.ResultsAUDIT‐C scores were available for 758 (82.5%) patients, of whom 107 (14.1%) fulfilled the criteria for hazardous alcohol consumption (AUDIT‐C score of 5/12 or higher for women and 6/12 or higher for men). Patients with hazardous alcohol consumption were younger, median age 59 (IQR 52.0–67.0) vs. 69.0 (IQR 63.0–74.0), p < .001, and more often men 93.5% vs. 71.9%, p < .001 than other patients and had an increased risk for ICU re‐admissions [adjusted OR (aOR) 4.37 (95% CI, 1.60–11.95)] and severe postoperative infections aOR 3.26 (95% CI, 1.42–7.54).ConclusionCardiac surgery patients with a history of hazardous alcohol consumption are younger than other patients and are predominantly men. Hazardous alcohol consumption is associated with an increased risk of severe postoperative infections and ICU re‐admissions.
Stock liquidity and tone of press releases
Authors: Gong Rong 
Published: November 2023

AbstractThis paper presents evidence that higher stock liquidity makes firms increase tone of press releases. I find that firms with higher stock liquidity have higher tone in press releases, relative to the tone of news initiated by media, than firms with lower stock liquidity. This relation is stronger for firms with greater short‐term pressure, that is, with greater transient institutional ownership, greater sensitivity of manager's wealth to stock price, and more analyst coverage. This finding suggests that stock liquidity, by producing short‐term pressure on firms, leads firms to boost press release tone.
Performance of International Classification of Disease‐10 codes in detecting emergency department patients with opioid misuse
Authors: Chhabra Neeraj , Smith Dale , Pachwicewicz Paul , Lin Yiqi , Bhalla Sameer , Maloney Caitlin M. , Blue Mennefer , Lee Power , Sharma Brihat , Afshar Majid , Karnik Niranjan S. 
Published: November 2023

AbstractBackground and AimsAccurate case discovery is critical for disease surveillance, resource allocation and research. International Classification of Disease (ICD) diagnosis codes are commonly used for this purpose. We aimed to determine the sensitivity, specificity and positive predictive value (PPV) of ICD‐10 codes for opioid misuse case discovery in the emergency department (ED) setting.Design and SettingRetrospective cohort study of ED encounters from January 2018 to December 2020 at an urban academic hospital in the United States. A sample of ED encounters enriched for opioid misuse was developed by oversampling ED encounters with positive urine opiate screens or pre‐existing opioid‐related diagnosis codes in addition to other opioid misuse risk factors.CasesA total of 1200 randomly selected encounters were annotated by research staff for the presence of opioid misuse within health record documentation using a 5‐point scale for likelihood of opioid misuse and dichotomized into cohorts of opioid misuse and no opioid misuse.MeasurementsUsing manual annotation as ground truth, the sensitivity and specificity of ICD‐10 codes entered during the encounter were determined with PPV adjusted for oversampled data. Metrics were also determined by disposition subgroup: discharged home or admitted.FindingsThere were 541 encounters annotated as opioid misuse and 617 with no opioid misuse. The majority were males (54.4%), average age was 47 years and 68.5% were discharged directly from the ED. The sensitivity of ICD‐10 codes was 0.56 (95% confidence interval [CI], 0.51–0.60), specificity 0.99 (95% CI, 0.97–0.99) and adjusted PPV 0.78 (95% CI, 0.65–0.92). The sensitivity was higher for patients discharged from the ED (0.65; 95% CI, 0.60–0.69) than those admitted (0.31; 95% CI, 0.24–0.39).ConclusionsInternational Classification of Disease‐10 codes appear to have low sensitivity but high specificity and positive predictive value in detecting opioid misuse among emergency department patients in the United States.
Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper
Authors: Bavbek Sevim , Kepil Özdemir Seçil , Bonadonna Patrizia , Atanaskovic‐Markovic Marina , Barbaud Annick , Brockow Knut , Laguna Martinez Jose , Nakonechna Alla , Pagani Mauro , Arcolacı Alessandra , Lombardo Carla , Torres Maria J. 
Published: November 2023

AbstractProton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence‐based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in‐depth investigations in the topic.
Patient perspectives of quality of life in chronic limb‐threatening ischemia: a qualitative study
Authors: Shan Leonard L. , Telianidis Stacey , Westcott Mark J. , Debono Deborah , Davies Alun H. , Choong Peter F. 
Published: November 2023

AbstractBackgroundQuality of life (QOL) is an outcome that matters to patients with chronic limb‐threatening ischemia (CLTI). However, we identified the lack of and need for a CLTI‐specific QOL instrument. Our group is developing this instrument which requires a deep understanding of patient perspectives of QOL in CLTI.MethodsQualitative inquiry with patient and public involvement was performed in accordance with the Standards for Reporting Qualitative Research. Reflexive thematic analysis of semi‐structured interviews was conducted within a constructivist‐interpretivist research paradigm. Data were organized and managed in NVivo. Techniques to enhance trustworthiness included maintaining an audit trail, member checking, mentoring, and peer‐debriefing. Patient and the public were consulted for feedback on codes, themes, and thematic maps.ResultsThirteen participants (median age: 74 years, range: 43–90 years) with a variety of patient demographics were interviewed. Four themes were developed on QOL in CLTI: (i) ‘independence as key to life satisfaction’, (ii) ‘change in identity when continuity is needed’, (iii) ‘coping with intractable disease’, and (iv) ‘not wanting to be alone’. Member checking with patient and public involvement confirmed the relevance and centrality of these themes to the lived experiences of patients with CLTI.ConclusionsThe thematic outputs contribute important insights into what QOL truly means to patients with CLTI and what matters for their QOL. The content validity of the new CLTI‐specific QOL instrument is improved by giving patients voice. This study highlights the value of qualitative inquiry and patient and public involvement in vascular surgical research.
Identity development and adjustment during emerging adulthood from a gender perspective
Authors: Sánchez‐Queija Inmaculada , Domínguez‐Alarcón Paula , Díez Marta , Parra Águeda 
Published: November 2023

AbstractIdentity development is a key task during emerging adulthood. The goals of the present study are to validate the Spanish version of the Dimensions of Identity Development Scale (DIDS) and to explore the relationship between identity dimensions and adjustment (flourishing and distress), from a gender perspective. The sample comprised 1502 Spanish university students (60.1% women). The results reveal that the DIDS is valid in the Spanish context and that significant gender differences were observed in some dimensions of identity development, with men scoring higher for identification with commitment and women scoring higher for exploration in depth and ruminative exploration. Finally, both dimensions of commitment and ruminative exploration had a stronger effect on men's than on women's adjustment, suggesting that the integration of the self has more impact on men's outcomes than on women's. These findings highlight the need to include the gender perspective in all future research in order to gain deeper insight into the relationship between the identity development process and adjustment during emerging adulthood.
Characteristics and long‐term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic
Authors: Castaño‐Díez Sandra , Pomares Helena , Esteban Daniel , Guijarro Francesca , Jiménez‐Vicente Carlos , Zugasti Inés , Álamo José Ramón , Mayayo Víctor Torrecillas , López‐Guerra Mònica , de la Fuente Cristina , Charry Paola , Cortés‐Bullich Albert , Bataller Álex , Maluquer Clara , Colomer Dolors , Rozman María , Arnan Montserrat , Xicoy Blanca , Esteve Jordi , Díaz‐Beyá Marina 
Published: November 2023

SummaryRecently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut‐off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)‐CMML. Five‐year survival was longer for OM‐CMML than for other patients (p < 0.001). Multivariate analysis identified OM‐CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5‐year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM‐CMML. Our results support the inclusion of OM‐CMML in the CMML category as a subtype with superior outcomes.
Unveiling the link between genetic alterations in gamma secretase and BCMA surface density in multiple myeloma
Authors: Cowan Andrew J. , Green Damian J. 
Published: November 2023

Cattaneo et al. report a unique case of a multiple myeloma patient with elevated B‐cell maturation antigen (BCMA) surface density, potentially due to genetic alterations in the gamma‐secretase protease complex—responsible for BCMA cleavage from plasma cells. No mutations in the BCMA gene were detected, but there was partial deletion of PSEN1 and amplification of PSEN2 (components of the gamma‐secretase complex), which may explain the lack of response to the gamma‐secretase inhibitor DAPT. This case, along with recent published literature, underscores the significance of gamma secretase in modulating BCMA density and the potential impact of its genetic alterations.Commentary on: Cattaneo et al. Genetic defects of gamma‐secretase genes in a multiple myeloma patient with high and dysregulated BCMA surface density: A case report. Br J Haematol 2024;204:571‐575.