bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Mineral Density Distribution in the Foot Bones and Correlation with Hindfoot Alignment
Authors: Mathieu Julie , Dagneaux Louis , Netto Cesar de Cesar , Bernasconi Alessio , Chabrand Patrick R. , Lintz François 
Published: December 2023

Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Weight-bearing CT (WBCT) enables accurate 3D hindfoot alignment (HA) measurements such as the Foot Ankle Offset (FAO). However, this uses anatomical landmarks and oversimplifies anatomy. Stress distribution influences bone mineral density (BMD). Hounsfield units (HU) are the tomographic measurement unit for BMD. We aim to analyze the distribution of BMD in the foot bones, relative to the long axis of the second metatarsal (M2), an accepted landmark for foot orientation, and its correlation with HA. Methods: In this retrospective study, 81 feet (27 per HA group : normal, valgus or varus) were included from our database after ethics approval. After 3D segmentation, a HU-weighted map (HUM) of the foot was projected on the ground plane with orientation defined by the longitudinal axis of the 2nd metatarsal. A HU Curve (HUC) was drawn, corresponding to the center of mass of the HUM in the coronal plane. We studied the HU angle (HUA) formed by HU Line (HUL) (linear regression of the HUC) and M2 longitudinal axis. Results: The groups were comparable by age, sex and BMI. A positive correlation between FAO and HU angle was found (r =0.75, p< 0.001). HUA were -0.4° ± 5.5° in varus, 3.5° ± 6.8° in normals, 13.4° ± 5.1° in valgus (F=39.7 and p< 0.001). HUA differences were significant between normals and varus (p < 0.05), and between normals and valgus (p < 0.001). FAO and HUA were significantly correlated in valgus (rho=0.437, p=0.002) and varus (rho=0.540, p=0.004). Conclusion: We found altered distributions in misaligned cases, and BMD was correlated with HA. The HUL could be an interesting new tool to analyse the topography of bone distribution in WBCT.
Comparison of Bone Healing and Delayed or Nonunion Rates Between Operatively and Non- operatively Treated Displaced Zone 1 Fifth Metatarsal Fractures
Authors: Kim C. James , Parekh Selene G. , Tsai Justin , O’Neil Joseph T. , Fuchs Daniel , Shakked Rachel , Winters Brian S. , Daniel Joe , Pedowitz David I. 
Published: December 2023

Category: Midfoot/Forefoot; Other Introduction/Purpose: Acute fractures of the proximal fifth metatarsal are one of the most common injuries to the foot, occurring in up to 70% of all metatarsal fractures1. Displaced zone 1 fractures of the fifth metatarsal with greater than 2 mm fracture gap or those comprising greater than 30% of the cubometatarsal joint warrant operative treatment with open reduction internal fixation (ORIF)2,7, as satisfactory bone healing and patient-reported outcomes have been reported previously8–13. More recently, a few studies have demonstrated good functional outcomes after conservative treatment of zone 1 fractures with initial displacement greater than 2 mm7,13. Nevertheless, the lack of comparative studies and conflicting available evidence of outcomes warrant further investigation on this topic. Methods: A chart review was conducted to identify patients with displaced zone 1 fractures of the fifth metatarsal. Age at time of injury, gender, smoking and diabetes history, were collected. Degree of fracture displacement were measured (mm) on AP, lateral, and oblique view radiographs obtained at the initial encounter. Non-operatively treated patients were instructed to weightbear as tolerated in a Controlled Ankle Motion (CAM) boot for 6 weeks. Surgically-treated patients were placed in a short-leg splint for 2 weeks, and remained non-weightbearing in a CAM boot until 6 week period. They transitioned to normal shoe wear at the 8 week postoperative period. Chart notes were reviewed to identify the time to complete healing and incidences of delayed or nonunion. Means were compared using a one-way ANOVA or Kruskal Wallis test depending on normality, and categorical variables were compared using Chi-square or Fisher’s exact test. Results: The average time to complete healing was greater in non-operatively treated patients by 3 weeks (17.1 vs. 14.1, p=0.282). 4/37 (10.8%) non-operatively treated patients experienced delayed or non-union whereas 4/38 (13.2%) operatively-treated patients experienced delayed or non-union. This difference was statistically non-significant. The average fracture displacement (mm) on the oblique view was significantly greater in operatively-treated patients (2.68 vs. 5.40, p< 0.001). For patients with fracture gaps greater than 2 mm on the oblique view, non-operatively treated patients took 20.9 weeks whereas operatively- treated patients took 11.8 weeks to reach complete healing (p < 0.01). Conclusion: Patients who were treated non-operatively for displaced zone 1 fractures of the fifth metatarsal took on average 3 weeks longer to reach complete healing than operatively-treated patients. For patients with fracture gap greater than 2 mm on the oblique view, operative treatment was associated with significantly reduced time to complete healing.
Correction of Distal Metatarsal Articular Angle in Hallux Valgus Surgery Utilizing a Minimally Invasive Percutaneous First Metatarsal Distal Transverse Osteotomy
Authors: Encinas Rodrigo , Edelman David , Hall SarahRose , McMillen Tucker , Jackson J. Benjamin , Gonzalez Tyler 
Published: December 2023

Category: Midfoot/Forefoot; Other Introduction/Purpose: Hallux valgus, a common deformity treated by orthopedic foot and ankle surgeons, can frequently present with an increased distal metatarsal articular angle (DMAA), which may require correction in addition to the hallux valgus deformity. Minimally invasive (MIS) percutaneous hallux valgus surgery is becoming more popular and often used in patients with increased DMAA. Additional recent literature has shown low rates of recurrence, minimal pain and high patient functional outcomes with MIS hallux valgus correction. Thus, we investigated the efficacy of MIS percutaneous distal transverse first metatarsal osteotomy procedure, a triplanar correction, in correcting the DMAA in hallux valgus surgery. We hypothesize that give the ability to obtain a triplanar correction with this osteotomy no additional osteotomy will be needed to correct the DMAA. Methods: A retrospective chart review was performed on patients who underwent the hallux valgus reconstruction with a MIS percutaneous distal transverse first metatarsal osteotomy between September 2021 to December 2022. Exclusion criteria included patients with inadequate follow up and all patients not undergoing MIS percutaneous distal transverse first metatarsal osteotomy for hallux valgus correction. Hallux valgus angle (HVA), intermetatarsal angle (IMA) and DMAA were measured on pre- operative and 2-week post-operative radiographs to assess immediate correction of these angles. Univariate analysis was used to describe pre- and post- measurements for DMAA, HVA, and IMA. Differences in pre- and post- measurements were evaluated using paired t-test. Results: In total, 43 minimally invasive surgery (MIS) hallux valgus corrections on 39 patients were included. On average, the DMAA decreased from 9.5 degrees pre-operatively to 4.8 degrees two weeks post-operatively (decrease of 4.7 degrees, p-value < 0.001). The average HVA decreased from 29.9 degrees pre-operatively to 4.2 degrees two weeks post-operatively (decrease of 25.7 degrees, p-value of < 0.001). Lastly, the average IMA decreased from 15.1 degrees pre-operatively to 2.9 degrees 2 weeks post-operatively (decrease of 12.2 degrees, p-value < 0.001). Conclusion: Our study showed that utilizing a MIS percutaneous distal transverse first metatarsal osteotomy for hallux valgus correction was able to significant reduce the DMAA without the need for supplementary metatarsal osteotomies. Additionally significant correction of the IMA and HVA was also obtained. MIS hallux valgus correction may be considered by orthopedic foot and ankle surgeons for those patients that need surgical correction for hallux valgus deformity that also requires DMAA correction.
Effectiveness of Platelet-rich Plasma Injections for Plantar Fasciitis: A Patient Reported Outcomes Evaluation
Authors: Nicolas Andrea Pujol , Nicholson Alys , Ramaskandhan Jayasree R. , Siddique Malik , Torres Paulo , Alkhreisat Mohammad , Qasim Sultan , Chambers Simon 
Published: December 2023

Category: Other Introduction/Purpose: Steroid injection is a common treatment for Plantar fasciitis (PF) but has high recurrence rates. Platelet- rich plasma (PRP) injections have been used as an alternative treatment. Our aim was to review the effectiveness of PRP injection. Methods: All patients who underwent PRP injection for PF between 2015 and 2021 were included in this study. Clinical results and patient reported outcomes (MOX-FQ scores, EQ-5D and FAOS scores) were collected pre and post-operatively. Results: A total of 34 patients underwent PRP injection between 2015 and 2021 (mean age 34 years). There was a 71% PROMs response rate (80% female with, mean age 53). The mean duration of symptoms was 4 years and the median follow up time was 4.2 years. 77.1% were satisfied with overall outcomes of treatment with PRP injections (p < 0.05). 68.1% of patients reported satisfaction with pain relief. 74.6% were satisfied with return to activities of daily living. 72.6% were satisfied with return to recreational activities. 59% reported improvement in quality-of-life post treatment. 64% were happy to receive the same treatment again; 13.6% would not have the procedure again. 2 patients had severe pain within 2 weeks following the injection but symptoms settled. No other complications. Conclusion: PF is considered to be a self-limiting condition but can be debilitating whilst awaiting resolution of symptoms which can take upwards of 12 months to fully resolve. PRP injection provides effective pain relief for PF at 4 years follow up.
How I diagnose and treat antiphospholipid syndrome in pregnancy
Authors: Branch D. Ware , Lim Ming Y. 
Published: December 2023

Abstract
Antiphospholipid syndrome (APS) is a rare autoimmune disease characterized by arterial, venous, or microvascular thrombosis, pregnancy morbidities, or nonthrombotic manifestations in patients with persistently positive antiphospholipid antibodies. These antibodies bind cellular phospholipids and phospholipid–protein complexes resulting in cellular activation and inflammation that lead to the clinical features of APS. Our evolving understanding of APS has resulted in more specific classification criteria. Patients meeting these criteria should be treated during pregnancy according to current guidelines. Yet, despite treatment, those positive for lupus anticoagulant have at least a 30% likelihood of adverse pregnancy outcomes. Patients with recurrent early miscarriage or fetal death in the absence of preeclampsia or placental insufficiency may not meet current classification criteria for APS. Patients with only low titer anticardiolipin or anti–β(2)-glycoprotein I antibodies or immunoglobulin M isotype antibodies will not meet current classification criteria. In such cases, clinicians should implement management plans that balance potential risks and benefits, some of which involve emotional concerns surrounding the patient’s reproductive future. Finally, APS may present in pregnancy or postpartum as a thrombotic microangiopathy, a life-threatening condition that may initially mimic preeclampsia with severe features but requires a very different treatment approach.
Antitumor efficacy and safety of unedited autologous CD5.CAR T cells in relapsed/refractory mature T-cell lymphomas
Authors: Hill LaQuisa C. , Rouce Rayne H. , Wu Mengfen J. , Wang Tao , Ma Royce , Zhang Huimin , Mehta Birju , Lapteva Natalia , Mei Zhuyong , Smith Tyler S. , Yang Lina , Srinivasan Madhuwanti , Burkhardt Phillip M. , Ramos Carlos A. , Lulla Premal , Arredondo Martha , Grilley Bambi , Heslop Helen E. , Brenner Malcolm K. , Mamonkin Maksim 
Published: December 2023

Abstract
Despite newer targeted therapies, patients with primary refractory or relapsed (r/r) T-cell lymphoma have a poor prognosis. The development of chimeric antigen receptor (CAR) T-cell platforms to treat T-cell malignancies often requires additional gene modifications to overcome fratricide because of shared T-cell antigens on normal and malignant T cells. We developed a CD5-directed CAR that produces minimal fratricide by downmodulating CD5 protein levels in transduced T cells while retaining strong cytotoxicity against CD5+ malignant cells. In our first-in-human phase 1 study (NCT0308190), second-generation autologous CD5.CAR T cells were manufactured from patients with r/r T-cell malignancies. Here, we report safety and efficacy data from a cohort of patients with mature T-cell lymphoma (TCL). Among the 17 patients with TCL enrolled, CD5 CAR T cells were successfully manufactured for 13 out of 14 attempted lines (93%) and administered to 9 (69%) patients. The overall response rate (complete remission or partial response) was 44%, with complete responses observed in 2 patients. The most common grade 3 or higher adverse events were cytopenias. No grade 3 or higher cytokine release syndrome or neurologic events occurred. Two patients died during the immediate toxicity evaluation period due to rapidly progressive disease. These results demonstrated that CD5.CAR T cells are safe and can induce clinical responses in patients with r/r CD5-expressing TCLs without eliminating endogenous T cells or increasing infectious complications. More patients and longer follow-up are needed for validation. This trial was registered at www.clinicaltrials.gov as #NCT0308190.
Association between doubly labelled water-calibrated energy intake and objectively measured physical activity with mortality risk in older adults
Authors: Watanabe Daiki , Yoshida Tsukasa , Watanabe Yuya , Yamada Yosuke , Miyachi Motohiko , Kimura Misaka 
Published: December 2023

Abstract
Background
Physical activity or biomarker-calibrated energy intake (EI) alone is associated with mortality in older adults; the interaction relationship between the combined use of both factors and mortality has not been examined. We evaluated the relationship between mortality and calibrated EI and step counts in older adults.

Methods
This prospective study included 4,159 adults aged ≥65 years who participated in the Kyoto-Kameoka study in Japan and wore a triaxial accelerometer between 1 April and 15 November 2013. The calibrated EI was calculated based on a previously developed equation using EI biomarkers. The step count was obtained from the accelerometer ≥ 4 days. Participants were classified into the following four groups: low EI (LEI)/low step counts (LSC) group (EI: <2,400 kcal/day in men and <1,900 kcal/day in women; steps: <5,000 /day), n = 1,352; high EI (HEI)/LSC group (EI: ≥2,400 kcal/day in men and ≥1,900 kcal/day in women; steps: <5,000 /day), n = 1,586; LEI/high step counts (HSC) group (EI: <2,400 kcal/day in men and < 1,900 kcal/day in women; steps: ≥5,000 /day), n = 471; and HEI/HSC group (EI: ≥2,400 kcal/day in men and ≥1,900 kcal/day in women; steps: ≥5,000 /day), n = 750. Mortality-related data were collected until 30 November 2016. We performed a multivariable Cox proportional hazard analysis.

Results
The median follow-up period was 3.38 years (14,046 person-years), and 111 mortalities were recorded. After adjusting for confounders, the HEI/HSC group had the lowest all-cause mortality rate compared to other groups (LEI/LSC: reference; HEI/LSC: hazard ratio [HR]: 0.71, 95% confidence interval [CI]: 0.41–1.23; LEI/HSC: HR: 0.59, 95% CI: 0.29–1.19; and HEI/HSC: HR: 0.10, 95% CI: 0.01–0.76). No significant interaction was observed between the calibrated EI and steps with mortality. The spline model showed that 35–42 kcal/100 steps/day of EI/100 steps was associated with the lowest mortality risk.

Conclusions
HR mortality risk was lowest at 35–42 kcal/100 steps/day, suggesting that very high (≥56 kcal) or low (<28 kcal) EI/100 steps are not inversely associated with mortality. Adherence to optimal EI and adequate physical activity may provide sufficient energy balance to explain the inverse association with mortality among older Japanese adults.
Synopsis of a Treasure. A Transdisciplinary Study of Medieval Gold Workings Biographies
Authors: Martiniello Stefania , Capitanio Antonella , Sciuto Claudia , Legnaioli Stefano , Raneri Simona 
Published: December 2023

Abstract
The article aims to show how a transdisciplinary approach can contribute to a better understanding of the composite biography of a precious object. The study focuses on the Cintola del Duomo (Museum of the Opera del Duomo, Pisa), one of the most famous objects in the history of goldsmithing, both for its exceptional manufacturing quality and for its devotional value. For a long time, the Cintola was considered a fragment of a long garland – decorated with precious stones, enamel, and silver plates – that was displayed on the façade of the Cathedral on certain days of the liturgical calendar. Detailed historical studies suggested that the garland was lost in the early 1300s, while the object now in the museum is more likely to be a reconstruction, decorated with ancient and modern gems. In situ diagnostic campaigns were carried out on the garland using portable Raman spectroscopy (i-Raman, B&W Tek) and portable X-Ray fluorescnece (XRF) (Elio, Bruker) to reveal the identity of the gems and enamels preliminarily studied by gemmological analysis. The combination of analytical techniques made it possible to better outline the complex history of the artefacts. The analysis provided information on the identity of the gems, proposing an interesting question about their possible relationship with the crown of Henry VII of Luxembourg (in the same museum). The study includes aspects related to the materiality of the objects, revealing the socio-cultural context in which the object was produced and supporting its recontextualisation in the museum as a symbolic representation of the past.
Synergistic role of thymoquinone and 5-fluorouracil in U-251MG glioblastoma cell line
Authors: Mutlu Altundağ Ergül , Jannuzzi Ayşe Tarbin , Özbilenler Cahit , Ustürk Selma , Altınoğlu Gülcem 
Published: December 2023

Abstract

Objectives
Glioblastoma is a fast-growing and aggressive brain tumor. Despite the current treatment methods, such as chemical and surgical operations, the prognosis is still poor. Therefore, combined therapeutic strategies are proposed to maximize therapeutic efficacy and reduce toxicity. Thymoquinone has been shown to have neuroprotective effects in addition to its anti-cancer effects on different types of cancer. 5-Fluorouracil, on the other hand, is a cytotoxic chemotherapy agent used to treat cancer. As a synergistic combinational approach, this study aimed to examine the antiproliferative effects and production of reactive oxygen species in a glioblastoma cell line.

Methods
We have tested thymoquinone and 5-fluorouracil alone and in their combination to observe cellular growth with MTT assay. The combinational effects of the agents were determined by the CompuSYN software program. Cell proliferation was assayed with crystal violet assay. Reactive oxygen species production was analyzed by 2′,7′-dichlorodihydrofluorescein diacetate in glioblastoma cells.

Results
Thymoquinone and 5-fluorouracil inhibited cell growth of glioblastoma cells with half maximal inhibitory concentrations (IC50) of 45.93 and 14.02 µM for 48 h, respectively. At synergistic combinational concentrations, the crystal violet assay demonstrated that there is a positive correlation between combination index values and cell proliferation. Also, an increment in the production of reactive oxygen species was observed upon combinational treatments.

Conclusions
Our results indicate that the combinational strategy of these two agents reduced cell viability and proliferation in glioblastoma cells and showed strong synergistic anticancer efficiency.
An overview of talent management: Make talent management a priority in start-ups
Authors: Midoun Sissani , Nardjes Frioua 
Published: December 2023

This research aims to review the literature and determine talent management as a key priority in most economic entities and start-ups representing high-growth, innovative potential in the new technologies sector. On the other hand, this article analyses different strategies used in start-ups to retain highly qualified employees, develop their skills, and motivate them constantly. It sheds light on finding gaps and suggests creating flexibility between different functions. Finally, we included the awareness of the Algerian policymakers, who try to give opportunities to project holders to realise their brilliant ideas through creating their start-ups and benefit from the business climate to achieve their goals through management and marketing strategies that can benefit their start-ups and their employees.
Diş hekimlerinin reçeteleme davranışını etkileyen faktörler
Authors: Ercan Tolgay , Biçer Enis Baha 
Published: December 2023

Sağlık harcamaları içinde ilaç harcamalarının önemli bir yer tutması, hekimin tedavide kilit durumda esas belirleyici olması ilaç firmaları ve sağlık politika yapıcılarının hekimlere olan ilgisini artırmaktadır. Dünyada antibiyotiklerin %10’u diş hekimleri tarafından yazılmaktadır. Bu durum ilaç firmalarının diş hekimlerine yönelik pazarlama faaliyetlerinin artmasına neden olmaktadır. Bu çalışma diş hekimlerinin ilaç reçetelemesine etki eden bilgi düzeylerine ilişkin faktörleri tanımlamaktadır. Diş hekimlerinin reçeteleme davranışlarının araştırılmasına yönelik olarak yapılmış orijinal bir çalışmadır. Araştırma Sivas ilinde diş hekimlerine kolayda örnekleme yöntemi ile örneklem hesaplanarak 152 anket uygulaması yapılmış uygun olan 145 anket kullanılmıştır. Elde edilen veriler demografik özelliklere göre farklılık analizleri hipotezlerinin sınanmasında parametrik testler kullanılmıştır. Araştırmada elde edilen sonuçlarda diş hekimlerinin reçeteleme davranışında klinik etkinlik, güvenlik, hasta uyumu, promosyon malzemeleri, kongre destekleri, tıbbi tanıtım temsilcisi ziyaret sıklığı, ilaç isminin etken madde benzerliği gibi faktörlerden etkilendiği, elde edilen sonuçların literatür ile uyumlu olduğu belirtilebilir.
TFRS 16 kiralamalar standardı kapsamında işletmelerin varlık ve kaynak yapıları üzerinde beklenen değişimin işletmelerin finansal durum tablolarına ve finansal oranlarına etkisi: BİST imalat sektöründe bir uygulama
Authors: Altunkara Özcan , Can Esin Nesrin 
Published: December 2023

Bu çalışmanın amacı, 01.01.2019 tarihinden itibaren uygulanmak üzere yürürlüğe giren Türkiye Finansal Raporlama Standardı 16 Kiralamalar standardının ortaya çıkardığı değişimin, Borsa İstanbul A.Ş.’de kayıtlı imalat sektöründeki işletmelerin finansal durum tablolarına etki düzeylerini belirlemektir. Bu amaçla, bu işletmelerin 2019, 2020 ve 2021 yılları çeyrek periyot dönemlerine ait finansal durum tablolarından ve dipnotlarından elde edilen kullanım hakkı varlıkları ve kiralama yükümlülükleri tutarlarının, işletmelerin likidite ve finansal yapı oranları ile etkisi panel veri analiz yöntemleri ile incelenmiştir. Araştırmanın bulguları değerlendirildiğinde; kullanım hakkı varlıklarında ortaya çıkan artışın, nakit oran ve stok bağımlılık oran değerleri üzerinde artışa neden olduğu cari oran, asit – test oranı, kaldıraç oranı, duran varlıklar / yabancı kaynaklar oranı, duran varlıklar / özkaynaklar oranı, özkaynaklar / aktif toplamı oranı ve finansman oranı üzerinde anlamlı bir etkiye sahip olmadığı, kira yükümlülüklerinde ortaya çıkan artışın, nakit oran ve stok bağımlılık oranı üzerinde artışa, duran varlıklar / yabancı kaynaklar oranı üzerinde azalışa neden olduğu cari oran, asit – test oranı, kaldıraç oranı, duran varlıklar / özkaynaklar oranı, özkaynaklar / aktif toplamı oranı ve finansman oranı üzerinde anlamlı bir etkiye sahip olmadığı görülmüştür.