bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operative vs Nonoperative Management of Acute Cholecystitis During the Different Trimesters of Pregnancy
Authors: Hantouli Mariam N. , Droullard David J. , Nash Michael G. , Benson Lyndsey S. , Wright Andrew S. , Flum David R. , Davidson Giana H. 
Published: November 2023

ImportanceAcute cholecystitis (AC) management during pregnancy requires balancing the risk of pregnancy loss or preterm delivery (adverse pregnancy outcomes [APOs]) with or without surgery. Guidelines recommend cholecystectomy across trimesters; however, trimester-specific evidence on the risks of AC and its management is lacking.ObjectiveTo assess cholecystectomy frequency in pregnant people with AC, compare the rates of APOs in pregnant people with or without AC, and compare the rates of APOs in people with AC who did or did not undergo cholecystectomy.Design, Setting, and ParticipantsThis retrospective, population-based cohort study used data for pregnant people with AC from the IBM MarketScan Commercial Claims and Encounters Database from January 1, 2007, to December 31, 2019, and a propensity score–matched cohort of pregnant people without AC. Trimester status (first [T1], second [T2], and third [T3]), APOs, and cholecystectomy were defined by administrative claims. Data were analyzed from October 2021 to July 2022.ExposuresPregnant patients with or without AC. Pregnant patients with AC who did or did not receive cholecystectomy.Main Outcomes and MeasuresThe main outcomes were cholecystectomy during pregnancy and APOs (ie, preterm delivery and pregnancy loss). Pregnant patients with and without AC were compared to assess the association of AC with risk of APOs. Propensity score inverse-probability weighting was used to calculate treatment-associated APO risk among patients with 1-year follow-up.ResultsThe study included 5759 pregnant patients with AC (mean [SD] age, 30.1 [6.6] years) and 23 036 controls (mean [SD] age, 29.9 [6.7] years) after propensity score matching. Among 3426 pregnant patients with AC and 1-year follow-up, 1182 (34.5%) underwent cholecystectomy during the pregnancy (684 [41.7%] presenting with AC in T1, 404 [40.4%] in T2, and 94 [12.0%] in T3). Acute cholecystitis during pregnancy, irrespective of treatment, was associated with higher odds of APO compared with no AC during pregnancy across all trimesters (odds ratio [OR], 1.69 [95% CI, 1.54-1.85]). Compared with nonoperative management, receipt of surgery was associated with lower odds of APOs across all trimesters (OR, 0.75 [95% CI, 0.63-0.87]), in T1 (OR, 0.81 [95% CI, 0.66-1.00]), in T2 (OR, 0.71 [95% CI, 0.50-1.00]), and in T3 (OR, 0.45 [95% CI, 0.28-0.70]).Conclusions and RelevanceIn this study, cholecystectomy was associated with lower risk of APO in patients with AC across all trimesters, with the greatest benefit in T3. However, only 34.5% overall and 12.0% of patients in T3 had a cholecystectomy. These findings support guidelines recommending cholecystectomy during pregnancy and should inform decision-making discussions. Greater guideline adherence and surgery use, especially in T3, may represent an opportunity to improve outcomes for pregnant people with AC.
Chemical Composition and Potential Antimicrobial and Anti‐Inflammatory Activities of Essential Oil from Fruits of Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm.
Authors: Hou Jiaojiao , Gong Huxuan , Gong Zan , Qin Xiangxiang , Nie Jing , Zhu Hua , Zhong Shian 
Published: November 2023

AbstractAlpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm. was extensively used in traditional medicine for its several properties, but continuous investigation is needed to discover the properties of its essential oils (EOs). This work evaluated the properties of an EO obtained by steam distillation (named ESD) as well as extracts obtained by petroleum ether (named EP) both from Alpinia zerumbet fruits. Gas chromatography‐mass spectrometry (GC‐MS) was chosen to identify the composition, and eleven compounds were identified as the main components of the EO and EP of Alpinia zerumbet fruits. The antimicrobial properties were investigated by minimum inhibitory concentration (MIC) and the inhibition area. The results identified the differences in antimicrobial activities attributed to different extraction methods. Enzyme‐linked immunosorbent assay (ELISA) and Western Blot (WB) assay were conducted to assess the anti‐inflammatory effects of ESD. In conclusion, our study suggested that EO from Alpinia zerumbet fruits might be a prospective candidate for antimicrobial and anti‐inflammatory therapy.
Catalytic Cracking of 1,3,5‐Triisopropylbenzene and Low‐Density Polyethylene over Hierarchical Y Zeolites and Al‐SBA‐15
Authors: Mensah Jim , Yan Penghui , Rawal Aditya , Lee Adam F. , Wilson Karen , Robinson Neil , Johns Michael L. , Kennedy Eric , Stockenhuber Michael 
Published: November 2023

AbstractCatalytic cracking of high molecular weight hydrocarbons underpins the production of fossil fuels from petroleum vapour and the recycling of polyolefin waste plastic. However, thermal cracking over conventional microporous solid acids is hindered by poor mass‐transport. Here we explore the performance of hierarchical H−Y zeolites and Al‐SBA‐15 for the catalytic cracking of 1,3,5‐triisopropylbenzene (1,3,5‐TIPB) and low‐density polyethylene (LDPE) in a continuous fixed‐bed flow reactor. Dealumination by acid washing was used to create hierarchical mesoporosity in H−Y zeolite and modify the solid acidity. Physicochemical properties were studied by X‐ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), gas adsorption, in‐situ Fourier transform infrared (FTIR), ex‐situ pyridine DRIFT, 29Si and 27Al nuclear magnetic resonance (NMR), and 1H relaxation and pulsed field gradient (PFG) NMR diffusion studies. Despite weakening acidity, the introduction of hierarchical porosity promotes deep cracking of both feedstocks; HNO3 dealuminated H−Y produces five times more cumene and benzene from 1,3‐5‐TIPB, and 33 % more benzene and xylenes from LDPE, than the parent H−Y.
Chemical looping gasification of biomass using rare earth oxides doped ferric oxide oxygen carrier for hydrogen‐rich syngas production
Authors: Lin Chengqian , Wang Jun , Huang Qunxing , Wang Shoukang , Jin Jianlong , Jin Yuqi , Chi Yong 
Published: November 2023

AbstractAn efficient oxygen carrier (OC) is in great demand in the biomass chemical looping gasification (BCLG) process. In the present study, an innovative rare earth oxide doped ferric oxide OC (Fe2O3−REaOb) derived from the Nd‐Fe‐B sintered magnet waste scraps was employed for the BCLG process for hydrogen‐rich syngas production. The critical variables, including the temperature of gasification, the mass ratio of OC/biomass, the mass ratio of steam/biomass, and the cycle performance of the novel OC, were investigated regarding syngas yield and carbon conversion efficiency. Results found that the optimum conditions were achieved at 900°C, with a mass ratio of OC to biomass of 3:1 and a mass ratio of steam to biomass of 0.4, and a syngas yield of 1.19 Nm3/kg with an H2/CO mole ratio of 2.45, and a carbon conversion efficiency of 76.80% was reached. Additionally, a comparison between Fe2O3−REaOb OC, Fe2O3−Al2O3 OC, and Fe2O3−CeO2 OC was also conducted, with Fe2O3−REaOb OC demonstrating a superior performance. The synergistic effects between REaOb and Fe2O3, particularly the generation of perovskite oxide NdFeO3, contributed to the excellent performance of the Fe2O3−REaOb OC during the BCLG process. The outward diffusion of Fe and sintering of the OC reduced the syngas yield and carbon conversion efficiency by about 16.00% and 25.00% over the 20 redox cycles of the BCLG process. In summary, Fe2O3−REaOb can be an efficient and promising OC for hydrogen‐rich syngas production in the BCLG process.
Living on the edge: Predicting songbird response to management and environmental changes across an ecotone
Authors: Van Lanen Nicholas J. , Monroe Adrian P. , Aldridge Cameron L. 
Published: November 2023

AbstractEffective wildlife management requires robust information regarding population status, habitat requirements, and likely responses to changing resource conditions. Single‐species management may inadequately conserve communities and result in undesired effects to non‐target species. Thus, management can benefit from understanding habitat relationships for multiple species. Pinyon pine and juniper (Pinus spp. and Juniperus spp.) are expanding into sagebrush‐dominated (Artemisia spp.) ecosystems within North America and mechanical removal of these trees is frequently conducted to restore sagebrush ecosystems and recover Greater Sage‐grouse (Centrocercus urophasianus). However, pinyon‐juniper removal effects on non‐target species are poorly understood, and changing pinyon‐juniper woodland dynamics, climate, and anthropogenic development may obscure conservation priorities. To better predict responses to changing resource conditions, evaluate non‐target effects of pinyon‐juniper removal, prioritize species for conservation, and inform species recovery within pinyon‐juniper and sagebrush ecosystems, we modeled population trends and density‐habitat relationships for four sagebrush‐associated, four pinyon‐juniper‐associated, and three generalist songbird species with respect to these ecosystems. We fit hierarchical population models to point count data collected throughout the western United States from 2008 to 2020. We found regional population changes for 10 of 11 species investigated; 6 of which increased in the highest elevation region of our study. Our models indicate pinyon‐juniper removal will benefit Brewer's Sparrow (Spizella breweri), Green‐tailed Towhee (Pipilo chlorurus), and Sage Thrasher (Oreoscoptes montanus) densities. Conversely, we predict largest negative effects of pinyon‐juniper removal for species occupying early successional pinyon‐juniper woodlands: Bewick's Wren (Thryomanes bewickii), Black‐throated Gray Warblers (Setophaga nigrescens), Gray Flycatcher (Empidonax wrightii), and Juniper Titmouse (Baeolophus ridgwayi). Our results highlight the importance of considering effects to non‐target species before implementing large‐scale habitat manipulations. Our modeling framework can help prioritize species and regions for conservation action, infer effects of management interventions and a changing environment on wildlife, and help land managers balance habitat requirements across ecosystems.
Integrated workflow for the identification of new GABAAR positive allosteric modulators based on the in silico screening with further in vitro validation. Case study using Enamine's stock chemical space
Authors: Platonov Maksym , Maximyuk Oleksandr , Rayevsky Alexey , Iegorova Olena , Hurmach Vasyl , Holota Yuliia , Bulgakov Elijah , Cherninskyi Andrii , Karpov Pavel , Ryabukhin Sergey , Krishtal Oleg , Volochnyuk Dmitriy 
Published: November 2023

AbstractNumerous studies reported an association between GABAAR subunit genes and epilepsy, eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar disorders. This study was aimed to find some potential positive allosteric modulators and was performed by combining the in silico approach with further in vitro evaluation of its real activity. We started from the GABAAR‐diazepam complexes and assembled a lipid embedded protein ensemble to refine it via molecular dynamics (MD) simulation. Then we focused on the interaction of α1β2γ2 with some Z‐drugs (non‐benzodiazepine compounds) using an Induced Fit Docking (IFD) into the relaxed binding site to generate a pharmacophore model. The pharmacophore model was validated with a reference set and applied to decrease the pre‐filtered Enamine database before the main docking procedure. Finally, we succeeded in identifying a set of compounds, which met all features of the docking model. The aqueous solubility and stability of these compounds in mouse plasma were assessed. Then they were tested for the biological activity using the rat Purkinje neurons and CHO cells with heterologously expressed human α1β2γ2 GABAA receptors. Whole‐cell patch clamp recordings were used to reveal the GABA induced currents.Our study represents a convenient and tunable model for the discovery of novel positive allosteric modulators of GABAA receptors. A High‐throughput virtual screening of the largest available database of chemical compounds resulted in the selection of 23 compounds. Further electrophysiological tests allowed us to determine a set of 3 the most outstanding active compounds. Considering the structural features of leader compounds, the study can develop into the MedChem project soon.
Efficacy of apparent diffusion coefficient values for normal submandibular glands and acute submandibular sialadenitis
Authors: Muraoka Hirotaka , Kaneda Takashi , Ito Kotaro , Hirahara Naohisa , Otsuka Kohei , Tokunaga Satoshi 
Published: November 2023

AbstractObjectiveThis study aimed to assess the apparent diffusion coefficient (ADC) values of normal salivary glands and acute submandibular sialadenitis (SS).MethodsThis retrospective study included 22 patients who underwent magnetic resonance imaging (MRI) at the Nihon University School of Dentistry between February 2018 and May 2022. ADC values were compared between the acute SS and control group. Data with non‐normality confirmed by Shapiro–Wilk test was analyzed using the Mann–Whitney U test, Spearman's correlation coefficient, and a receiver operating characteristic (ROC) curve. Statistical significance was set at p < 0.05.ResultsThe mean ADC values were 1.03 ± 0. 09 × 10−3 and 1.22 ± 0.17 × 10−3 mm2/s in the normal and acute SS groups, respectively (p < 0.001). ROC analysis revealed a cutoff ADC value of 1.1 for distinguishing acute SS from the normal.ConclusionThese findings suggest that ADC values are useful for the quantitative assessment of acute SS.
Low‐cost BPO4 In Situ Synthetic Li3PO4 Coating and B/P‐Doping to Boost 4.8 V Cyclability for Sulfide‐Based All‐Solid‐State Lithium Batteries
Authors: Shi Jie , Ma Zhihui , Wu Di , Yu Yue , Wang Zhen , Fang Yixing , Chen Dishuang , Shang Shuai , Qu Xuanhui , Li Ping 
Published: November 2023

AbstractStructural damage of Ni‐rich layered oxide cathodes such as LiNi0.8Co0.1Mn0.1O2 (NCM811) and serious interfacial side reactions and physical contact failures with sulfide electrolytes (SEs) are the main obstacles restricting ≥4.6 V high‐voltage cyclability of all‐solid‐state lithium batteries (ASSLBs). To tackle this constraint, here, a modified NCM811 with Li3PO4 coating and B/P co‐doping using inexpensive BPO4 as raw materials via the one‐step in situ synthesis process is presented. Phosphates have good electrochemical stability and contain the same anion (O2−) and cation (P5+) as in cathode and SEs, respectively, thus Li3PO4 coating precludes interfacial anion exchange, lessening side reactivity. Based on the high bond energy of B─O and P─O, the lattice O and crystal texture of NCM811 can be stabilized by B3+/P5+ co‐doping, thereby suppressing microcracks during high‐voltage cycling. Therefore, when tested in combination with Li─In anode and Li6PS5Cl solid electrolytes (LPSCl), the modified NCM811 exhibits extraordinary performance, with 200.36 mAh g−1 initial discharge capacity (4.6 V), cycling 2300 cycles with decay rate as low as 0.01% per cycle (1C), and 208.26 mAh g−1 initial discharge capacity (4.8 V), cycling 1986 cycles with 0.02% per cycle decay rate. Simultaneously, it also has remarkable electrochemical abilities at both −20 °C and 60 °C.
Faculty – Graduate teaching assistant mentoring model: Chaos theory in action
Authors: Harrison Jamie , Roodsari Sedighe Zamani 
Published: November 2023

AbstractIn this study, collaboration has been revisited between an American faculty member and an international graduate teaching assistant during a unique faculty‐student mentoring model within principles of chaos theory. The role of culture, beliefs about language learning and teaching had been studied closely to improve faculty/international students’ cooperation in academic settings. The research focused on the nature of the collaborative experience of a faculty member and a graduate teaching assistant in designing and implementing an authentic language learning experience into a graduate level linguistic course and the role of dynamism and chaos theory evident in this mentoring model. Participants engaged in collaborative planning of a language learning experience embedded into a graduate level linguistic course. Reflective journals of participants and assignments were analyzed to better understand the experiences of the collaborators and the ways their culture, beliefs, and mentoring model impacted andragogical choices for instruction and learning of participants and students. Through self‐study, the researchers explored their professional identity and their academic flexibility within the organizational boundaries. The results of the study unveiled the complexity and chaos of each phase of cooperation and how the participants applied flexibility to achieve a more linear teaching/learning process. The collaboration between American faculty and international GTA under the shadow of chaos twisted by culture, beliefs, and hierarchy could still generate novice andragogical practices in higher education to contribute implications for collaborative work across cultures and hierarchies.
Evaluating the feasibility, utility, and impact of engaging in mentorship assessment to improve doctoral mentoring relationships
Authors: Fedesco Heather N. , Kraner Ella Rose , Dolan Erin L. 
Published: November 2023

AbstractThis article describes a mentorship assessment structure designed to improve doctoral student‐research advisor mentoring relationships. We report the experiences of students and advisors as they completed the process to assess the feasibility, utility, and impact of engaging in mentorship assessment.
Die Pflicht zur Anpassung der Landesraumordnungspläne an Ziele der Bundesraumordnungspläne – Rechtsfragen des neuen §13 Abs. 1a ROG
Authors: Kümper Boas 
Published: November 2023

ZusammenfassungDurch das Gesetz zur Änderung des Raumordnungsgesetzes und anderer Vorschriften vom 3.3.2023
(ROGÄndG) hat der Bundesgesetzgeber mit §13 Abs. 1a ROG eine Pflicht zur Anpassung der Landesraumordnungspläne,
d.h. der landesweiten und regionalen Raumordnungspläne, zur Anpassung an die in den Raumordnungsplänen
des Bundes festgelegten Ziele der Raumordnung aufgenommen. Die im Gefüge von Bundes- und Landesplanung
neuartige und im Gesetzgebungsprozess umstrittene Vorschrift soll der in §1 Abs. 4 BauGB vorgesehenen
Verpflichtung der Gemeinden zur Anpassung ihrer Bauleitpläne an die Ziele der Raumordnung nachempfunden
sein. Der Beitrag geht den durch §13 Abs. 1a ROG aufgeworfenen Rechtsfragen nach.
Breaking away from an endemic state of multidrug-resistant Pseudomonas aeruginosa by daily sink disinfection
Authors: Iwasaki Sumio , Sato Rikako , Kagami Keisuke , Akizawa Kouji , Hayasaka Kasumi , Fukumoto Tatsuya , Taki Keisuke , Niinuma Yusuke , Yamada Takehiro , Oyamada Reiko , Watanabe Tsubasa , Nakakubo Sho , Watanabe Chiaki , Teshima Takanori , Ishiguro Nobuhisa 
Published: November 2023

Abstract
The detection rate of multidrug-resistant Pseudomonas aeruginosa in patients admitted to 2 wards and the intensive care unit decreased from 20.3% (129 of 636 isolates) to 4.2% (37 of 889 isolates) after the start of disinfection of hand washing sinks using alkyl diaminoethylglycine hydrochloride.
Little James: Μικρός as an Indication of Height or Affection not Comparative Age in Mark 15.40
Authors: Soon Isaac T. 
Published: November 2023

AbstractThis article argues that, based on a close reading of the ancient textual, documentary and epigraphic evidence, the expression ὁ μικρός in Mark 15.40 is most likely a nickname regarding this James’ particular height or potentially an affectionate indication that he is a child. The expression ὁ μικρός is not an indication of comparative age to another person (‘younger’). The evidence from ancient epigraphy and the LXX, initially provided by Adolf Deissmann to support a longstanding reading of ὁ μικρός as ‘the younger’ in Mark 15.40, proves to be less than reliable.
Mechanical actuation via resorbable materials
Authors: Parkinson Bethany , Sargent Brandon , Roubicek Clark , Magleby Spencer , Garcia Victor , Howell Larry 
Published: November 2023

Abstract
Resorbable materials – or materials which diffuse into their surroundings – present a promising means of actuating mechanical systems. In current practice, such as in the realm of in vivo surgical devices, resorbable materials are intended to perform a temporary function and completely dissolve when that function is completed (e.g., resorbable sutures). In this paper, resorbable materials are proposed for use in a different way: as a means for actuation. We propose an approach and physical prototypes to demonstrate that resorbable materials, combined with stored energy, can be used to actuate mechanical systems under several loading conditions and in various applications. Rotary and linear actuation methods, as well as gradual and delayed instantaneous actuations, are demonstrated. Using the principles illustrated here, resorbable materials offer unique, customizable ways to actuate a variety of mechanisms in a wide range of domains.
Background Pycnocline Depth Constrains Future Ocean Heat Uptake Efficiency
Authors: Newsom Emily , Zanna Laure , Gregory Jonathan 
Published: November 2023

AbstractThe Ocean Heat Uptake Efficiency (OHUE) quantifies the ocean's ability to mitigate surface warming through deep heat sequestration. Despite its importance, the main controls on OHUE, and on its two‐fold spread across contemporary climate models, remain unclear. We argue that OHUE is primarily controlled by mid‐latitude ventilation strength in the background climate, itself related to pycnocline depth and stratification. This hypothesis is supported by a strong correlation between mid‐latitude (30–60°) OHUE and the near‐global average (60°S–60°N) pycnocline depth in CMIP5 and CMIP6 AOGCMs under RCP85/SSP585, and in a parameter perturbation ensemble of ocean GCM (MITgcm) experiments. This correlation explains about 70% of the CMIP5‐6 spread in global OHUE. The relationship provides a pathway toward observationally constraining OHUE, and thus reducing uncertainty in projections of future global climate change and sea level rise.