bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle factors associated with a rapid decline in the estimated glomerular filtration rate over two years in older adults with type 2 diabetes–Evidence from a large national database in Japan
Authors: Li Yaya , Fujii Makoto , Ohno Yuko , Ikeda Asuka , Godai Kayo , Nakamura Yuko , Akagi Yuya , Yabe Daisuke , Tsushita Kazuyo , Kashihara Naoki , Kamide Kei , Kabayama Mai 
Published: December 2023

Background
The present study investigated lifestyle risk factors from metabolic syndrome-related lifestyles for a rapid decline in the estimated glomerular filtration rate (eGFR) among adults aged 40–74 years with treated and untreated type 2 diabetes.

Methods and results
This study analyzed data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, encompassing the period from fiscal year (FY) 2017 to FY2020. We established FY2018 as our baseline year. The subjects of this study were adults aged 40–74 in FY2018(baseline) who had type 2 diabetes and underwent specific health checkups in FY2020. We excluded adults with a medical record of kidney dialysis between FY2017 and FY2018, records of suspected type 1 diabetes between FY2017 and FY2020, or a baseline eGFR >85 mL/min/1.73 m2 or missing eGFR data as of FY2020. Eventually we analyzed 573,860 individuals. The outcome variable was a rapid decline in eGFR (≥30%) during the follow-up. Exposure lifestyle factors included skipping breakfast, late-night dinners, regular smoking, a high alcohol intake, non-refreshing sleep, and a lack of habitual exercise. Logistic regression models were stratified by age (40–59 and 60–74 years) and baseline eGFR levels (60–85, 30–59, and <30 mL/min/1.73 m2). Covariates included sex, a history of heart disease, a history of stroke, a history of renal failure, anemia, low-density lipoprotein, systolic blood pressure, hemoglobin A1C, body mass index, antidiabetic medications, antihypertension drugs, lipid-lowering drugs, the oral adsorbent Kremezin, non-steroidal anti-inflammatory drugs, and drugs for the treatment of renal anemia. A rapid decline in eGFR was detected in approximately 1.3% of participants (7,683 cases). In the baseline eGFR >30 subgroups (60–85 or 30–59 mL/min/1.73 m2), skipping breakfast and regular smoking were associated with a rapid decline in eGFR in both age groups, while a lack of habitual exercise and late-night dinners in the 60–74 age group and non-refreshing sleep in the 40–59 age group were identified as risk factors. Additionally, skipping breakfast was a risk factor for a rapid decline in eGFR in the 60–74 age group regardless of baseline eGFR levels. In the baseline eGFR <30 mL/min/1.73 m2 subgroup, skipping breakfast and non-refreshed sleep were risk factors for a rapid decline in eGFR.

Conclusions
We found specific lifestyle risk factors were associated with a rapid eGFR decline among people with type 2 diabetes from a nationwide database in Japan. The associations varied by baseline eGFR level, age, and sex. Lifestyle modifications may effectively prevent the aggravation of diabetic kidney disease.
Performance of Prediction Models for Esophageal Squamous Cell Carcinoma in General Population: A Systematic Review and External Validation Study
Authors: Jiang Hao , Chen Ru , Li Yanyan , Hao Changqing , Song Guohui , Hua Zhaolai , Li Jun , Wang Yuping , Wei Wenqiang 
Published: December 2023

INTRODUCTION:
Prediction models for esophageal squamous cell carcinoma (ESCC) need to be proven effective in the target population before they can be applied to population-based endoscopic screening to improve cost-effectiveness. We have systematically reviewed ESCC prediction models applicable to the general population and performed external validation and head-to-head comparisons in a large multicenter prospective cohort including 5 high-risk areas of China (Fei Cheng, Lin Zhou, Ci Xian, Yang Zhong, and Yan Ting).

METHODS:
Models were identified through a systematic review and validated in a large population-based multicenter prospective cohort that included 89,753 participants aged 40–69 years who underwent their first endoscopic examination between April 2017 and March 2021 and were followed up until December 31, 2022. Model performance in external validation was estimated based on discrimination and calibration. Discrimination was assessed by C-statistic (concordance statistic), and calibration was assessed by calibration plot and Hosmer-Lemeshow test.

RESULTS:
The systematic review identified 15 prediction models that predicted severe dysplasia and above lesion (SDA) or ESCC in the general population, of which 11 models (4 SDA and 7 ESCC) were externally validated. The C-statistics ranged from 0.67 (95% confidence interval 0.66–0.69) to 0.70 (0.68–0.71) of the SDA models, and the highest was achieved by Liu et al (2020) and Liu et al (2022). The C-statistics ranged from 0.51 (0.48–0.54) to 0.74 (0.71–0.77), and Han et al (2023) had the best discrimination of the ESCC models. Most models were well calibrated after recalibration because the calibration plots coincided with the x = y line.

DISCUSSION:
Several prediction models showed moderate performance in external validation, and the prediction models may be useful in screening for ESCC. Further research is needed on model optimization, generalization, implementation, and health economic evaluation.
Active Labour Market Policies: What Works for the Long-Term Unemployed?
Authors: Eppel Rainer , Huemer Ulrike , Mahringer Helmut , Schmoigl Lukas 
Published: December 2023

Abstract
There is still a lack of knowledge on how to effectively help the long-term unemployed into employment. We evaluate a wide range of active labour market policies for this target group, using a dynamic matching approach. Measures vary considerably in the extent to which they improve labour market prospects. Human capital-intensive training programs that substantially enhance vocational skills and employment programs are most effective, short activating job search training the least. Our results suggest that not only wage subsidies in the private sector, but also direct job creation in the public and non-profit sectors can work, if properly designed.
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests
Authors: Seok Hyeon Seok , Choi Yuna , Yu Shinae , Shin Kyung-Hwa , Kim Sollip , Shin Hangsik 
Published: December 2023

Abstract

Objectives
Misidentification errors in tumor marker tests can lead to serious diagnostic and treatment errors. This study aims to develop a method for detecting these errors using a machine learning (ML)-based delta check approach, overcoming limitations of conventional methods.

Methods
We analyzed five tumor marker test results: alpha-fetoprotein (AFP), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), carcinoembryonic antigen (CEA), and prostate-specific antigen (PSA). A total of 246,261 records were used in the analysis. Of these, 179,929 records were used for model training and 66,332 records for performance evaluation. We developed a misidentification error detection model based on the random forest (RF) and deep neural network (DNN) methods. We performed an in silico simulation with 1 % random sample shuffling. The performance of the developed models was evaluated and compared to conventional delta check methods such as delta percent change (DPC), absolute DPC (absDPC), and reference change values (RCV).

Results
The DNN model outperformed the RF, DPC, absDPC, and RCV methods in detecting sample misidentification errors. It achieved balanced accuracies of 0.828, 0.842, 0.792, 0.818, and 0.833 for AFP, CA19-9, CA125, CEA, and PSA, respectively. Although the RF method performed better than DPC and absDPC, it showed similar or lower performance compared to RCV.

Conclusions
Our research results demonstrate that an ML-based delta check method can more effectively detect sample misidentification errors compared to conventional delta check methods. In particular, the DNN model demonstrated superior and stable detection performance compared to the RF, DPC, absDPC, and RCV methods.
Enhanced supercapacitive performance of electrophoretically deposited nanostructured molybdenum-doped Mn3O4 thin films
Authors: Patil Tanaji S. , Kamble Raviraj S. , Patil Rahul B. , Takale Mansing V. , Gangawane Satish A. 
Published: December 2023

Abstract
Nanostructured molybdenum (Mo)-doped Mn3O4 thin films were successfully deposited on stainless steel substrates by a facile electrophoretic deposition technique. The effect of Mo doping on the structural and supercapacitive properties of Mn3O4 thin films was investigated. The nanostructured morphology of spinel tetragonal Hausmannite Mn3O4 thin films was elucidated with the help of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Raman studies. The presence of mesopores in the nanostructure with an average pore size of 41 nm was confirmed by Brunauer–Emmett–Teller studies. The different valence states of Mn and Mo are confirmed by X-ray photoelectron spectroscopy. The symmetrical quasi-rectangular-shaped cyclic voltammetry curves without any redox peak and nearly triangular/symmetric galvanostatic charge–discharge curves for Mn3O4 thin films elucidated the pseudocapacitive behavior. Electrochemical impedance spectroscopy revealed that pure and Mo-doped Mn3O4 thin films have lower resistances. Improved supercapacitive performance of 2 % Mo-doped Mn3O4 thin film was confirmed by higher specific capacitance 497 F g−1 at a current density of 1.6 A g−1. The boosted supercapacitive performance of Mo-doped Mn3O4 thin films has identified the outstanding incorporation of Mo ions into the Mn3O4 lattice.
Range augmentation of 16 × 60 GHz WDM RoFSO system in foggy & rainy weather
Authors: Kaur Kamaldeep , Nain Abhimanyu 
Published: December 2023

Abstract
The wavelength division multiplexed radio over free space optics (WDM RoFSO) system is a paramount candidate to provide extended range thus enabling efficient last mile connectivity. But the conventional design is unable to transmit the information up to larger distances under harsh climate conditions. An improved 16 channel WDM-RoFSO system is proposed and simulated which yields quality transmission for extended range under the attenuation of 5.8 dB/km, 7.7 dB/km, 9.2 dB/km and 26 dB/km for foggy and rainy conditions respectively. A radio frequency (RF) signal of 60 GHz is modulated over an optical signal carrier and successfully transported with cumulative 16 × 10 Gbps bit rate up to 3.75 km in foggy environment. The link range is augmented by 1.65 km, 0.9 km, 1.8 km & 1 km for light fog, moderate fog, moderate rainfall and heavy rainfall conditions respectively.
Reconsidering the Chaîne Opératoire: At the Crossroad Between People and Materials
Authors: Porqueddu Marie-Elise , Sciuto Claudia , Lamesa Anaïs 
Published: December 2023

Abstract
This article is an introductory contribution to our Special Issue Reconsidering the Chaîne Opératoire: Towards a Multifaceted Approach to the Archaeology of Techniques. The chaîne opératoire is a central and fundamental concept for archaeological studies that has been fully appropriated and repurposed by several generations of researchers. In this paper, we would like to present some of the points discussed and illustrated by the various articles in this special issue. The aim is to highlight theoretical and practical considerations in various fields, with a diachronic focus. From the biographical approach to the study of artefacts to the challenges of interdisciplinarity through cognitive and sensory approaches, the theoretical discussion is rich and innovative, acknowledging that the chaîne opératoire can be used as a tool for deciphering the complex network of artefacts, environments, and societies of the past and present.
Green transformation in the health sector and medical laboratories, adaptation to climate change in Türkiye
Authors: Aykal Güzin 
Published: December 2023

Abstract
Societal habits’ continuation is expected to result in severe consequences for climate change, causing significant environmental damage and humanitarian crises. Sustainability, defined as meeting present needs without compromising future generations, balances environment, equity, and economy. Türkiye, a middle-income developing country, has committed to achieving net-zero emissions by 2053 under the United Nations’ framework. The construction sector is increasingly adopting eco-friendly practices, emphasizing green buildings and structures. Several green hospital certification systems, including BREEAM, LEED, and Australian Green Star, are now in use, with around 20 certified “green hospitals” in Türkiye. The “Zero Waste Project” initiated in Türkiye aims to reduce waste generation and resource usage efficiently. Recent efforts have focused on sustainability in high-carbon footprint medical laboratories, however, an international standard has not been established yet. Clinical chemistry and laboratory medicine federations have established working groups on the subject. Universities and nonprofits worldwide offer green laboratory certificate programs covering energy conservation, green chemistry, waste management, and water conservation. Laboratories’ sustainability efforts encompass inventory management, green purchasing, test request reduction, greenhouse gas management, efficient building design, transportation choices, carbon footprint calculations, and education. The guides published in Türkiye are “Health Institutions Wastewater/Liquid Waste Management Handbook” and “Guide for Laboratory and Dialysis Wastes”. Türkiye’s Ministry of Health introduced the “Rational Test Request Procedure” to enhance diagnostic accuracy and cost-effectiveness by reducing unnecessary tests. Collective efforts are essential to raise awareness and implement precautions, particularly in high-carbon footprint medical laboratories, addressing climate change and sustainability challenges in the healthcare sector.
Comparison of lignocellulosic enzymes and CAZymes between ascomycetes (Trichoderma) and basidiomycetes (Ganoderma) species: a proteomic approach
Authors: Shankar Akshay , Jain Kavish Kumar , Kuhad Ramesh Chander , Sharma Krishna Kant 
Published: December 2023

Abstract
Wood decomposing ascomycetes and basidiomycetes group of fungi are the most valuable microbes on the earth’s ecosystem that recycles the source of carbon; therefore, they are essential for the biorefinery industries. To understand the robustness of the enzymes and their metabolic pathways in the fungal system, label-free quantification of the total proteins was performed. The fungi showed a comparable quantity of protein abundance [Trichoderma citrinoviride (285), Thermoascus aurantiacus (206), Ganoderma lucidum MDU-7 (102), G. lucidum (242)]. Differentially regulated proteins of ascomycetes and basidiomycetes were analyzed, and their heatmap shows upregulated and downregulated proteins [25 differentially expressed proteins in T. citrinoviride (8.62 % up-regulated and 91.37 % down-regulated) and G. lucidum (5.74 % up-regulated and 94.25 % down-regulated)] by using the normalized peptide-spectrum match (PSMs) and log2fold change. These proteins were similarly matched to the carbohydrate active enzymes family (CAZymes) like glycoside hydrolase (GH family), carbohydrate-binding module (CBM family) with auxiliary activities, and also involved in the hydrolysis of carbohydrate, lignin, xylan, polysaccharides, peptides, and oxido-reductase activity that helps in antioxidant defense mechanism. The lignocellulolytic enzymes from two different divisions of fungi and proteomics studies gave a better understanding of carbon recycling and multi-product lignocellulosic biorefinery processes.
Eccentric Force-Velocity-Load Relationship in Trained Rugby Union Athletes
Authors: McNeill Conor , Beaven C. Martyn , McMaster Daniel T. , Ward Patrick , Gill Nicholas 
Published: December 2023

Abstract
McNeill, C, Beaven, CM, McMaster, DT, Ward, P, and Gill, N. Eccentric force-velocity-load relationship in trained rugby union athletes. J Strength Cond Res XX(X): 000–000, 2023—The force-velocity relationship is traditionally believed to resemble a hyperbolic shape, known as the “force-velocity curve.” However, there is less evidence regarding this relationship during eccentric muscle action in multijoint isotonic exercise, especially in applied settings. The purpose of this study was to investigate the force-velocity-load relationship in an incremental eccentric back squat test. In addition, 37 professional male rugby union athletes were recruited to participate. Separate generalized linear mixed models were used to analyze the effect of barbell load on relative eccentric peak force (REPF), relative eccentric mean force (REMF), eccentric peak velocity (EPV), and eccentric mean velocity (EMV). A significant effect of load (p < 0.05) was observed for each of the eccentric variables tested. Each increase in barbell load tended to result in a linear increase in REMF and a decrease in EMV and EPV; however, we observed a plateauing effect for REPF as load increased. These results show that for “peak” variables lighter loads produced similar magnitudes of force, but generally moved at higher velocities than heavier loads. These observations suggest that the eccentric force-velocity-load relationship may vary depending on the parameters used. Quantifying rapid, multijoint eccentric performance is justified as it seems to provide valuable insight into individual athletic capability and training program design. Further research may investigate the responsiveness of the qualities to training and the causal nature of eccentric characteristics and athletic performance.
External Load Fluctuations Across an Amateur Athletic Union Basketball Season
Authors: Kutson Constantine W. , Russell Jennifer L. , Strack Donnie , Coutts Aaron J. , McLean Blake D. 
Published: December 2023

Abstract
Kutson, CW, Russell, JL, Strack, D, Coutts, AJ, and McLean, BD. External load fluctuations across an Amateur Athletic Union basketball season. J Strength Cond Res XX(X): 000–000, 2023—Amateur Athletic Union (AAU) competitions are an important component of the developmental pathway for youth basketball athletes. Despite its relative importance, there is currently a paucity of research investigating the physical demands in AAU basketball. Therefore, the purpose of this study was to examine the physical demands encountered over the course of an AAU basketball season. External training load was quantified using inertial sensors (Catapult T6) from one male AAU basketball team (age: 17.5 ± 0.5 years, height: 197.3 ± 10.0 cm, and mass: 89.4 ± 11.6 kg) over the course of the 2021 AAU season and categorized post hoc into high-, medium-, and low-minute groups based on mean playing minutes. After player categorization, 2 linear mixed models were constructed, one for PlayerLoad (PL) and one for duration, to examine the differences across player category, month of the season, and activity types (practices or games). The results show that the highest training loads were encountered by high-minute players, who had total PLs of 9,766 ± 1,516 AU, 13,207 ± 2,561 AU, and 7,071 ± 2,122 AU during April, May, and June, respectively. Highly variable training loads were also evident over the course of a season, with peak PL values as high as 4,921 AU per week. Practitioners should be aware that AAU basketball players experience variable loads throughout the season, which peak around congested competition/tournament periods. In addition, players with high game minutes accumulate the most load over the course of a season. This information may be used to better inform planning and periodizing strategies during developmental phases.
Moderators of Resistance Training Effects in Healthy Young Women: A Systematic Review and Meta-analysis
Authors: Molinari Talita , Radaelli Régis , Rech Anderson , Brusco Clarissa M. , Markarian Anna Maria , Lopez Pedro 
Published: December 2023

Abstract
Molinari, T, Radaelli, R, Rech, A, Brusco, CM, Markarian, AM, and Lopez, P. Moderators of resistance training effects in healthy young women: A systematic review and meta-analysis. J Strength Cond Res XX(X): 000–000, 2023—To systematically review and analyze the effects of resistance-based exercise programs and potential moderators of change in body fat percentage, whole-body fat and lean mass, muscle hypertrophy, muscle strength, and muscle power/rapid force in healthy young women (between 18 and 35 years). A systematic search was undertaken in 7 databases from inception to May 2022. Eligible randomized controlled trials examined the effects of resistance-based exercise programs on outcomes of interest in healthy young women. Meta-analysis was undertaken with a 3-level mixed-effects model. Associations between standardized mean difference (SMD) and potential moderators (number of sessions, weekly volume, and intensity) were tested by meta-regression models. Statistical significance was set at an α level of 0.05, whereas an α level of 0.05–0.10 was also considered for potential moderators of resistance training effects. Forty articles (n = 1,312) were included. Resistance-based exercise programs resulted in a significant improvement of 0.4 SMD (95% confidence intervals [95% CI]: 0.2 to 0.5, p < 0.001) in lean mass/muscle hypertrophy and 1.2 SMD (95% CI: 0.9 to 1.5, p < 0.001) in muscle strength. A higher number of sessions was associated with changes in lean mass/muscle hypertrophy (β = 0.01 ± 0.00, p = 0.009), whereas a higher weekly volume approached statistical significance to moderate changes in muscle strength (β = 0.01 ± 0.01, p = 0.053). Body fat percentage (−0.4 SMD, 95% CI: −0.6 to −0.1, p = 0.006) and muscle power/rapid force (0.6 SMD, 95% CI: 0.2 to 1.1, p = 0.011) were significantly improved. In conclusion, a higher resistance training volume was associated with greater improvements in lean mass/muscle hypertrophy, muscle strength, and body fat percentage, whereas muscle power/rapid force improvements were observed irrespective of prescription characteristics. These findings may help in designing resistance training programs for muscle hypertrophy, strength and power, and body fat percentage in healthy women.