bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible antibacterial degradable bioelastomer nanocomposites for ultrasensitive human–machine interaction sensing enabled by machine learning
Authors: Fu Zihong , Wang Mingcheng , Huang Chenlin , Li Zehui , Yuan Yue , Hu Shikai , Zhang Liqun , Wan Pengbo 
Published: February 2024

AbstractFlexible wearables have attracted extensive interests for personal human motion sensing, intelligent disease diagnosis, and multifunctional electronic skins. However, the reported flexible sensors, mostly exhibited narrow detection range, low sensitivity, limited degradability to aggravate environmental pollution from vast electronic wastes, and poor antibacterial performance to hardly improve skin discomfort and skin inflammation from bacterial growth under long‐term wearing. Herein, bioinspired from human skin featuring highly sensitive tactile sensation with spinous microstructures for amplifying sensing sensitivity between epidermis and dermis, a wearable antibacterial degradable electronics is prepared from degradable elastomeric substrate with MXene‐coated spinous microstructures templated from lotus leaf assembled with the interdigitated electrode. The degradable elastomer is facilely obtained with tunable modulus to match the modulus of human skin with improved hydrophilicity for rapid degradation. The as‐obtained sensor displays ultra‐low detection limit (0.2 Pa), higher sensitivity (up to 540.2 kPa−1), outstanding cycling stability (>23,000 cycles), a wide detection range, robust degradability, and excellent antibacterial capability. Facilitated by machine learning, the collected sensing signals from the integrated sensors on volunteer's fingers to the related American Sign Language are effectively recognized with an accuracy up to 99%, showing excellent potential in wireless human movement sensing and smart machine learning‐enabled human–machine interaction.
Identification of novel MYH14 variants in families with autosomal dominant sensorineural hearing loss
Authors: Duman Duygu , Ramzan Memoona , Subasioglu Asli , Mutlu Ahmet , Peart LéShon , Seyhan Serhat , Guo Shengru , Ila Kadri , Balta Burhan , Kalcioglu Mahmut Tayyar , Bademci Guney , Tekin Mustafa 
Published: February 2024

AbstractAutosomal dominant sensorineural hearing loss (ADSNHL) is a genetically heterogeneous disorder caused by pathogenic variants in various genes, including MYH14. However, the interpretation of pathogenicity for MYH14 variants remains a challenge due to incomplete penetrance and the lack of functional studies and large families. In this study, we performed exome sequencing in six unrelated families with ADSNHL and identified five MYH14 variants, including three novel variants. Two of the novel variants, c.571G > C (p.Asp191His) and c.571G > A (p.Asp191Asn), were classified as likely pathogenic using ACMG and Hearing Loss Expert panel guidelines. In silico modeling demonstrated that these variants, along with p.Gly1794Arg, can alter protein stability and interactions among neighboring molecules. Our findings suggest that MYH14 causative variants may be more contributory and emphasize the importance of considering this gene in patients with nonsyndromic mainly post‐lingual severe form of hearing loss. However, further functional studies are needed to confirm the pathogenicity of these variants.
Severe unilateral refractory epistaxis arising from the septal branch of the anterior ethmoid artery
Authors: Nguyen Theodore V. , Bitner Benjamin F. , Hong Ellen M. , Pang Jonathan C. , Meller Leo Li Tang , Nguyen Cecilia , Kuan Edward C. 
Published: February 2024

Key Points
The septal branch of the anterior ethmoid artery (sbAEA) is an underrecognized source of severe refractory epistaxis.
Herein, we describe the presentation, predisposing factors, treatment strategies, and outcomes of a series of patients with this condition.
Surface Reconstruction on Metal Nitride during Photo‐oxidation
Authors: Liu Siqi , Qi Weiliang , Yang Xuhui , Guo Xuyun , Liu Jue , Zhu Ye , Yang Min‐Quan , Yang Minghui 
Published: February 2024

AbstractThe efficient conversion and storage of solar energy for chemical fuel production presents a challenge in sustainable energy technologies. Metal nitrides (MNs) possess unique structures that make them multi‐functional catalysts for water splitting. However, the thermodynamic instability of MNs often results in the formation of surface oxide layers and ambiguous reaction mechanisms. Herein, we present on the photo‐induced reconstruction of a Mo‐rich@Co‐rich bi‐layer on ternary cobalt‐molybdenum nitride (Co3Mo3N) surfaces, resulting in improved effectiveness for solar water splitting. During a photo‐oxidation process, the uniform initial surface oxide layer is reconstructed into an amorphous Co‐rich oxide surface layer and a subsurface Mo−N layer. The Co‐rich outer layer provides active sites for photocatalytic oxygen evolution reaction (POER), while the Mo‐rich sublayer promotes charge transfer and enhances the oxidation resistance of Co3Mo3N. Additionally, the surface reconstruction yields a shortened Co−Mo bond length, weakening the adsorption of hydrogen and resulting in improved performance for both photocatalytic hydrogen evolution reaction (PHER) and POER. This work provides insight into the surface structure‐to‐activity relationships of MNs in solar energy conversion, and is expected to have significant implications for the design of metal nitride‐based catalysts in sustainable energy technologies.
Increasing the Accessibility of Internal Catalytic Sites in Covalent Organic Frameworks by Introducing a Bicontinuous Mesostructure
Authors: Liu Yamei , Zhou Qin , Yu Hongde , Yang Qiqi , Wang Mingchao , Huang Chuanhui , Xiang Luoxing , Li Chen , Heine Thomas , Hu Guoqing , Wang Shengyao , Feng Xinliang , Mai Yiyong 
Published: February 2024

AbstractIntroducing continuous mesochannels into covalent organic frameworks (COFs) to increase the accessibility of their inner active sites has remained a major challenge. Here, we report the synthesis of COFs with an ordered bicontinuous mesostructure, via a block copolymer self‐assembly‐guided nanocasting strategy. Three different mesostructured COFs are synthesized, including two covalent triazine frameworks and one vinylene‐linked COF. The new materials are endowed with a hierarchical meso/microporous architecture, in which the mesochannels exhibit an ordered shifted double diamond (SDD) topology. The hierarchically porous structure can enable efficient hole‐electron separation and smooth mass transport to the deep internal of the COFs and consequently high accessibility of their active catalytic sites. Benefiting from this hierarchical structure, these COFs exhibit excellent performance in visible‐light‐driven catalytic NO removal with a high conversion percentage of up to 51.4 %, placing them one of the top reported NO‐elimination photocatalysts. This study represents the first case of introducing a bicontinuous structure into COFs, which opens a new avenue for the synthesis of hierarchically porous COFs and for increasing the utilization degree of their internal active sites.
Understanding super‐partnerships in scientific collaboration: Evidence from the field of economics
Authors: Liu Junwan , Guo Xiaofei , Xu Shuo , Bu Yi , Sugimoto Cassidy R. , Larivière Vincent , Song Yinglu , Zhou Honghao 
Published: February 2024

AbstractSuper‐partnerships exist between scholars connected within densely‐knit collaboration networks. Understanding how such relationships affect scholars' careers is of great importance. In this paper, focusing on the longitudinal aspects of scientific collaboration, we analyze collaboration profiles from the egocentric perspective and use analytic extreme value thresholds to identify super‐partners. A total of 5722 pairs of super‐partners are found in the field of economics. The several interesting findings about super‐partners are summarized as follows. (1) The collaboration pattern of super‐partners can be divided into three types: the dual‐core, bridge, and triangle types. (2) Gender disparities are reflected in the collaboration among super‐partners, and the stability of super‐partnerships involving different combinations of genders displays different characteristics. The random‐effect model is constructed to explore the effect of a super‐partnership on both parties from the aspects of productivity and influence, which also shows gender disparities. (3) A super‐partnership contributes to above‐average productivity and citation impacts of the publication for three collaboration patterns, and the research improvement of the triangle type is the greatest among the three types. Overall, this paper explores the characteristics of super‐partners and the added value of a long‐term commitment, which provides quantitative insights into the effect on scientific collaboration associated with close collaboration.
Konzept eines Digitalen Zwillings für Brückenbauwerke in der Betriebsphase
Authors: Collin Fabian , Ulbrich Lisa , Jesse Frank 
Published: February 2024

AbstractDas Konzept des Digitalen Zwillings hält auch im Brückenbau Einzug. Die während der Betriebsphase anfallenden Daten aus der Bauwerksprüfung, dem Bauwerksmonitoring und der Bauwerksdiagnostik sollen zukünftig in aggregierter Form die Grundlage bilden, um die derzeit reaktive Instandsetzung in eine prädiktive Instandhaltung zu überführen. Dieser Beitrag stellt ein Konzept für einen Objektzwilling mit dem Konnektivitätsgrad eines Digitalen Schattens im Reifegrad 2 vor. Es werden Kriterien für eine präzise Definition des Begriffs Digitaler Zwilling aufgeführt, BIM‐Anwendungsfälle für die Betriebsphase von Brücken definiert sowie notwendige Fachmodelle daraus abgeleitet. Mit Blick auf das Forschungsprojekt IDA‐KI werden Anforderungen an den Digitalen Zwilling aufgestellt und ein Softwarekonzept für deren prototypische Umsetzung erarbeitet. Dabei wird besonderer Fokus auf die Bereitstellung der IFC‐Fachmodelle in einer CDE als auch auf den Veredelungsprozess von Monitoringdaten gelegt.
Identifying chemical markers in wine‐processed Salvia miltiorrhiza using ultrahigh‐performance liquid chromatography‐quadrupole‐time‐of‐flight‐tandem mass spectrometry
Authors: Xu Tingting , Li Xiuwei , Sun Guodong , Wei Wenfeng , Huo Jinhai , Wang Weiming 
Published: February 2024

AbstractTo find the chemical markers of wine‐processed Salvia miltiorrhiza (WSM), 76 constituents, including diterpenoid quinones and phenolic acids in Salvia miltiorrhiza (SM) and WSM, were profiled using ultrahigh‐performance liquid chromatography‐quadrupole‐time‐of‐flight‐tandem mass spectrometry (UPLC‐Q‐TOF‐MS/MS) in positive‐ and the negative‐ion modes. Thirty compounds were screened out as candidate differential components using chemometrics analysis, and the concentration of most compounds increased after processing with wine. Seven compounds, namely tanshinone IIA, magnesium lithospermate B, salvianolic acid G, cryptotanshinone, isocryptotanshinone, salvianolic acid B, and rosmarinic acid, were selected as chemical markers of WSM using variable importance of the project. This study revealed the chemical markers of WSM and confirmed that WSM can improve the extraction and solubility effect of chemical constituents.
Values and diagnostic accuracy of sensory nerve action potentials in control participants and participants with diabetes with and without clinical diabetic neuropathy, based on neuropathy scale measurements
Authors: Abuzinadah Ahmad R. , Alrawaili Moafaq S. , Alshareef Aysha A. , Alkully Hussien S. , Milyani Haneen , Alamri Bashayr , Alshora Weam , Bamaga Ahmed K. 
Published: February 2024

AbstractBackgroundThe assessment of the normative values of sensory nerve action potentials (SNAP) and their diagnostic accuracies using validated neuropathy‐assessment tools to classify participants into groups with and without neuropathy was not previously described in the literature.MethodsThe Utah Early Neuropathy Scale (UENS), Michigan neuropathy‐screening instrument, and nerve conduction data were collected prospectively. We described and compared the values of the sural, superficial peroneal sensory (SPS), and superficial radial SNAP amplitude in different age groups for three groups. Group 1 (G1)—control participants (UENS <5), group 2 (G2)—participants with diabetes without clinical diabetic neuropathy (UENS <5), and group 3 (G3)—participants with clinical diabetic neuropathy (UENS ≥5). We also described the diagnostic accuracy of single‐nerve amplitude and a combined sensory polyneuropathy index (CSPNI) that consists of four total points (one point for each of the following nerves if their amplitude was <25% lower limit of normal: right sural, left sural, right SPS, and left SPS potentials).ResultsWe assessed 135 participants, including 41, 37, and 57 participants in G1, G2, and G3, respectively, with age median (interquartile ranges) of 51 (45–56), 47 (38–56), and 54 (51–61) years, respectively, whereas 19 (46.3%), 18 (48.7%), and 32 (56.14%) of them were males, respectively. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) scores were 68.4%, 92.3%, 86.7%, and 80% for the sural amplitude; 86%, 58.3%, 62%, and 84% for the SPS amplitude; 66.7%, 94.4%, 90.5%, and 78.2% for the CSPNI of 3; and 54.4%, 98.6%, 96.9%, and 73.2% for the CSPNI of 4, respectively.ConclusionSural nerve had a high specificity for neuropathy; however, the CSPNI had the highest specificity and PPV, whereas the SPS had the highest sensitivity and NPV.
Unraveling the impact of financial literacy on investment decisions in an emerging market
Authors: Shroff Sumita Jagdishprasad , Paliwal Udai Lal , Dewasiri Narayanage Jayantha 
Published: February 2024

AbstractWe examined the impact of financial literacy on investment decisions, taking a sample of 384 investors from India. A multi‐dimensional construct to measure financial literacy was developed basis the theory of planned behavior. Investment decisions were measured by taking six proxies on a five‐point Likert‐type scale. The causal link between financial literacy and investment decisions was examined using simple linear and binary logistic regression. The results exhibited moderate to high levels of financial literacy among investors. Results further confirm that investors' investment decisions are positively influenced by their financial literacy levels. It is concluded that financial literates have a greater likelihood of making informed investment decisions. These outcomes have practical implications for policymakers, managers, employers, and investors, especially in an emerging market context, making a case for relevant financial education programs to empower investors. The study adds to the theory of financial literacy developing a multi‐dimensional construct and introducing Macroeconomic Factors as a proxy for investment decisions.
Ultrasound clinical references of the healthy toenail unit
Authors: López Ripado Olga , Villar Rodríguez Julia , Mingorance Álvarez Esther , Pérez Pico Ana Mª. , García Nogales Agustín , Mayordomo Acevedo Raquel 
Published: February 2024

AbstractThe toenail unit, commonly called the nail, is one of the most frequently examined and treated structures in clinical podiatry. Ultrasound is a standard clinical technique because it is a noninvasive, painless, and rapid diagnostic tool. The main objective of this study was to obtain morphometric data of the healthy toenail unit by ultrasound for clinical application. The nails of 76 participants (152 hallux nails; 38 men, 38 women, average age 26.83 ± 12.20) were examined using a VINNO E35 ultrasound system and an X6‐16L linear probe with a frequency of 18 MHz. Five ultrasound measures of the healthy toenail unit were obtained, of which only the distance from the center of the distal phalange to the nail plate varied with age, sex, weight, and foot (p‐values ≤ 0.050). The other four parameters were less influenced by the variables analyzed, except sex, which influenced nearly all (p‐values ≤ 0.050). In one of these variables, indications of significance were observed (p‐values = 0.060), with greater distances in the men than in the women, except for nail plate curvature, which showed a higher value. The other variables studied did not influence the parameters analyzed. High‐frequency ultrasound can be used to examine the healthy toenail unit and define anthropometric reference measurements that can be used for more accurate and comparative diagnosis.
Cardiotoxicity and ROS Protection Assessment of three Structure‐Related N‐Acylhydrazones with Potential for the Treatment of Neurodegenerative Diseases
Authors: Helena Eduarda Santa , De Falco Anna , Cukierman Daphne S. , Gioda Adriana , Gioda Carolina Rosa , Rey Nicolás A. 
Published: February 2024

AbstractThe senescence process is associated with accumulated oxidative damage and increased metal concentration in the heart and brain. Besides, abnormal metal‐protein interactions have also been linked with the development of several conditions, including Alzheimer's and Parkinson's diseases. Over the years we have described a series of structure‐related compounds with different activities towards models of such diseases. In this work, we evaluated the potential of three N‐acylhydrazones (INHHQ: 8‐hydroxyquinoline‐2‐carboxaldehyde isonicotinoyl hydrazone, HPCIH: pyridine‐2‐carboxaldehyde isonicotinoyl hydrazone and X1INH: 1‐methyl‐1H‐imidazole‐2‐carboxaldehyde isonicotinoyl hydrazone) to prevent oxidative stress in cellular models, with the dual intent of being active on this pathway and also to confirm their lack of cardiotoxicity as an important step in the drug development process, especially considering that the target population often presents cardiovascular comorbidity. The 8‐hydroxyquinoline‐contaning compound, INHHQ, exhibits a significant cardioprotective effect against hydrogen peroxide and a robust antioxidant activity. However, this compound is the most toxic to the studied cell models and seems to induce oxidative damage on its own. Interestingly, although not possessing a phenol group in its structure, the new‐generation 1‐methylimidazole derivative X1INH showed a cardioprotective tendency towards H9c2 cells, demonstrating the importance of attaining a compromise between activity and intrinsic cytotoxicity when developing a drug candidate.
Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications
Authors: Fromager Bénédicte , Cambedouzou Julien , Marhuenda Emilie , Iskratsch Thomas , Pinault Mathieu , Bakalara Norbert , Cornu David 
Published: February 2024

AbstractGrowing cells in a biomimetic environment is critical for tissue engineering as well as for studying the cell biology underlying disease mechanisms. To this aim a range of 3D matrices have been developed, from hydrogels to decellularized matrices. They need to mimic the extracellular matrix to ensure the optimal growth and function of cells. Electrospinning has gained in popularity due to its capacity to individually tune chemistry and mechanical properties and as such influence cell attachment, differentiation or maturation. Polyacrylonitrile (PAN) derived electrospun fibres scaffolds have shown exciting potential due to reports of mechanical tunability and biocompatibility. Building on previous work we fabricate here a range of PAN fibre scaffolds with different concentrations of carbon nanotubes. We characterize them in‐depth in respect to their structure, surface chemistry and mechanical properties, using scanning electron microscopy, image processing, ultramicrotomic transmission electron microscopy, x‐ray nanotomography, infrared spectroscopy, atomic force microscopy and nanoindentation. Together the data demonstrate this approach to enable finetuning the mechanical properties, while keeping the structure and chemistry unaltered and hence offering ideal properties for comparative studies of the cellular mechanobiology. Finally, we confirm the biocompatibility of the scaffolds using primary rat cardiomyocytes, vascular smooth muscle (A7r5) and myoblast (C2C12) cell lines.
Transcatheter tricuspid valve replacement for functional tricuspid regurgitation after left‐sided valve surgery: A single‐center experience
Authors: Wang Yiwei , Zhai Mengen , Mao Yu , Yang Tingting , Zhu Guangyu , Liu Yang , Yang Jian 
Published: February 2024

AbstractBackgroundFunctional tricuspid regurgitation (FTR) following left‐sided valve surgery (LSVS) is of clinical significance due to its high recurrence and mortality rates. Transcatheter therapy presents a potential solution to address this issue.AimsThe study aimed to assess the safety and efficacy of transcatheter tricuspid valve replacement using the Lux‐Valve system in a single center for patients with FTR after LSVS.MethodsFrom June 2020 to April 2023, 20 patients with symptomatic severe FTR after LSVS were referred to our center. A multidisciplinary cardiac team evaluated these patients for suitability for transcatheter tricuspid valve replacement with Lux‐Valve systems. Primary efficacy and safety endpoints were immediate postoperative tricuspid regurgitation severity ≤ moderate and major adverse events during follow‐up.ResultsTwenty patients (average age 65.7 ± 7.4 years; 65.0% women) successfully underwent Lux‐Valve system implantation after LSVS. All patients achieved ≤ moderate tricuspid regurgitation immediately after the procedure. Only one patient (5.0%) experienced a procedure‐related major adverse event, leading to in‐hospital mortality due to pulmonary infection. At the 6‐month follow‐up, 17 patients (89.5%) improved to New York Heart Association functional class I to II (p < 0.001). The overall Kansas City Cardiomyopathy Questionnaire score significantly improved (35.9 ± 6.7 points to 58.9 ± 5.8 points, p < 0.001).ConclusionThe Lux‐Valve system was found to be safe and effective for treating FTR after LSVS. It resulted in positive early outcomes, including a significant reduction in FTR, improved functional status, and enhanced quality of life, especially in high‐risk patients.
Endodontic treatment of a C‐shaped mandibular second molar with narrow dentinal thickness: A case report
Authors: Mehrjouei Mina , Jafarzadeh Hamid , Esmaeelpour Pourya , Khorasanchi Maryam 
Published: February 2024

Key Clinical MessageFormulating an effective root canal treatment plan necessitates clinician awareness of the complexities of the root canal system and possible anatomic challenges. The C‐shaped canal variation accompanying the radicular lingual groove makes the lingual dentinal wall so thin that cleaning and shaping of canals require accurate management. This report presents endodontic treatment of a C‐shaped mandibular second molar diagnosed with pulpal necrosis and asymptomatic apical periodontitis, that initial radiographic assessment revealed extremely thin (0.3 mm) width of the lingual wall of the canals prone to perforation. Mechanical preparation was performed through the anti‐curvature technique and basically by chemical irrigation rather than mechanical instrumentation. The C‐shaped isthmus was prepared up to 25/02 rotary system without dentinal defect while maintaining adequate dentin thickness so as to not significantly reduce the strength of the root. Follow‐up radiographs showed normal periodontal ligament and lamina dura indicating significant healing of the periapical lesion.