bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of working in vulnerable contexts on the mental health of primary healthcare professionals during the COVID-19 pandemic: a mixed-methods study
Authors: de Miranda Kleverson Gomes , Rodrigues da Silva Izabel Cristina , Fonseca Rafaela M A Martins , Gallassi Andrea Donatti 
Published: November 2023

ObjectiveThe objective of this study is to analyse the relationship and psychosocial issues between working during the COVID-19 pandemic in primary healthcare (PHC) facilities located in the most vulnerable health region (HR) of the Federal District of Brazil (FDB) compared with a lesser region.DesignMixed-method study data. The questionnaire was based on the World Health Survey and the Convid Behavioural Survey. Quantitative data were described in absolute and relative frequency. Pearson’s χ2test verified differences according to the region (significance level <5%). A margin of error of 8% with 95% CI defined the sample. The content analysis (by Bardin) analysed the qualitative data.SettingA representative sample of PHC professionals working at the Western HR and Central HR of the FDB.Participants111 women and 27 male PHC professionals, aged ≥ 18 years.Outcome measuresPsychosocial variables—personal emotions towards the clients, social relationships and use of psychoactive substances (PAS).InterventionAn online questionnaire (27 questions) and 1 open-ended question.ResultsThe sample comprised 138 PHC professionals; 80.40% were female aged between 40 and 49 years old (27.3%); declared themselves as black/pardo (58.7%); were married (53.60%), and worked in family healthcare teams (47.80%). No association between working in the most vulnerable HR compared with the least one and presenting psychosocial issues, except for anger towards clients (p=0.043). 55.10% worked much more than usual, 60.80% reported being depressed, 78.20% anxious, 76.80% stressed, 77.50% had no empathy and 78.30% felt isolated from family/friends. Towards the clients, 59.40% reported empathy and 72.5% no affection/care. The consume of psychotropic medications was reported by 34.80%, and 14.50% increased alcohol/PAS use. Qualitative data leverage quantitative findings: work overload, the indifference of the Federal Government and distance from family/friends.ConclusionWorking in the most vulnerable region and in the least one affects the psychosocial aspects of the PHC professionals equally.
Study protocol for a longitudinal observational study of disparities in sleep and cognition in older adults: the DISCO study
Authors: Knutson Kristen L. , Pershing Mandy L , Abbott Sabra , Alexandria Shaina J , Chiluka Sindhu , Chirinos Diana , Giachello Aida , Gupta Niket , Harrington Katharine , Rittner Sarah S , Sorond Farzaneh , Wong Mandy , Vu Thanh-Huyen T. , Zee Phyllis C , Carnethon Mercedes R. 
Published: November 2023

IntroductionCognitive dysfunction, a leading cause of mortality and morbidity in the USA and globally, has been shown to disproportionately affect the socioeconomically disadvantaged and those who identify as black or Hispanic/Latinx. Poor sleep is strongly associated with the development of vascular and metabolic diseases, which correlate with cognitive dysfunction. Therefore, sleep may contribute to observed disparities in cognitive disorders. The Epidemiologic Study of Disparities in Sleep and Cognition in Older Adults (DISCO) is a longitudinal, observational cohort study that focuses on gathering data to better understand racial/ethnic sleep disparities and illuminate the relationship among sleep, race and ethnicity and changes in cognitive function. This investigation may help inform targeted interventions to minimise disparities in cognitive health among ageing adults.Methods and analysisThe DISCO study will examine up to 495 individuals aged 55 and older at two time points over 24 months. An equal number of black, white and Hispanic/Latinx individuals will be recruited using methods aimed for adults traditionally under-represented in research. Study procedures at each time point will include cognitive tests, gait speed measurement, wrist actigraphy, a type 2 home polysomnography and a clinical examination. Participants will also complete self-identified assessments and questionnaires on cognitive ability, sleep, medication use, quality of life, sociodemographic characteristics, diet, substance use, and psychological and social health.Ethics and disseminationThis study was approved by the Northwestern University Feinberg School of Medicine Institutional Review Board. Deidentified datasets will be shared via the BioLINCC repository following the completion of the project. Biospecimen samples from the study that are not being analysed can be made available to qualified investigators on review and approval by study investigators. Requests that do not lead to participant burden or that conflict with the primary aims of the study will be reviewed by the study investigators.
What health inequalities exist in access to, outcomes from and experience of treatment for lung cancer? A scoping review
Authors: Lennox Laura , Lambe Kate , Hindocha Chandni N , Coronini-Cronberg Sophie 
Published: November 2023

ObjectivesLung cancer (LC) continues to be the leading cause of cancer-related deaths and while there have been significant improvements in overall survival, this gain is not equally distributed. To address health inequalities (HIs), it is vital to identify whether and where they exist. This paper reviews existing literature on what HIs impact LC care and where these manifest on the care pathway.DesignA systematic scoping review based on Arksey and O’Malley’s five-stage framework.Data sourcesMultiple databases (EMBASE, HMIC, Medline, PsycINFO, PubMed) were used to retrieve articles.Eligibility criteriaSearch limits were set to retrieve articles published between January 2012 and April 2022. Papers examining LC along with domains of HI were included. Two authors screened papers and independently assessed full texts.Data extraction and synthesisHIs were categorised according to: (a) HI domains: Protected Characteristics (PC); Socioeconomic and Deprivation Factors (SDF); Geographical Region (GR); Vulnerable or Socially Excluded Groups (VSG); and (b) where on the LC pathway (access to, outcomes from, experience of care) inequalities manifest. Data were extracted by two authors and collated in a spreadsheet for structured analysis and interpretation.Results41 papers were included. The most studied domain was PC (32/41), followed by SDF (19/41), GR (18/41) and VSG (13/41). Most studies investigated differences in access (31/41) or outcomes (27/41), with few (4/41) exploring experience inequalities. Evidence showed race, rural residence and being part of a VSG impacted the access to LC diagnosis, treatment and supportive care. Additionally, rural residence, older age or male sex negatively impacted survival and mortality. The relationship between outcomes and other factors (eg, race, deprivation) showed mixed results.ConclusionsFindings offer an opportunity to reflect on the understanding of HIs in LC care and provide a platform to consider targeted efforts to improve equity of access, outcomes and experience for patients.
Muscle strength, not muscle mass, determines the health-related quality of life in Indonesian women with systemic lupus erythematosus
Authors: Sumantri Stevent , Seto Euphemia , Rengganis Iris 
Published: November 2023

ObjectiveNo study evaluated the impact of low muscle strength and mass on the Sarcopenia-related Quality of Life (SarQoL) in women with SLE.MethodsThis cross-sectional study recruited 145 women with SLE consecutively; muscle strength was measured with a calibrated Jamar handheld dynamometer, muscle mass was measured with appendicular muscle mass index (Tanita MC-780 MAP body impedance analyser) and health-related quality of life with SarQoL Questionnaire. The cut-off points for low muscle strength, low muscle mass and sarcopenia were derived from the Asian Working Group on Sarcopenia 2019. Statistical analysis was conducted with a t-test for mean difference, and logistic regression was used to evaluate for low muscle strength contributing factors.ResultsThere was a significant difference in the mean total score of SarQoL in individuals with normal compared with low muscle strength (74.36 vs 64.85; mean difference 9.50; 95% CI 2.10 to 5.33; p<0.001). On the other hand, there was no difference in individuals with normal compared with low muscle mass (71.07 vs 70.79; mean difference 0.28; −5.18 to 5.74; p=0.91). After minimally adjusted with age, we found moderate-severe joint pain (B −9.280; p<0.001) and low muscle strength (B −6.979; p=0.001) to be independently associated with low mean SarQoL total score.ConclusionThere was a lower total SarQoL score in individuals with low muscle strength but not with low muscle mass.
Confined run-and-tumble model with boundary aggregation: Long-time behavior and convergence to the confined Fokker–Planck model
Authors: Fu Jingyi , Liang Jiuyang , Perthame Benoit , Tang Min , Zhong Chuhan 
Published: November 2023

The motile micro-organisms such as Escherichia coli, sperm, or some seaweed are usually modeled by self-propelled particles that move with the run-and-tumble process. Individual-based stochastic models are usually employed to model the aggregation phenomenon at the boundary, which is an active research field that has attracted a lot of biologists and biophysicists. Self-propelled particles at the microscale have complex behaviors, while characteristics at the population level are more important for practical applications but rely on individual behaviors. Kinetic PDE models that describe the time evolution of the probability density distribution of the motile micro-organisms are widely used. However, how to impose the appropriate boundary conditions that take into account the boundary aggregation phenomena is rarely studied. In this paper, we propose the boundary conditions for a 2D confined run-and-tumble model (CRTM) for self-propelled particle populations moving between two parallel plates with a run-and-tumble process. The proposed model satisfies the relative entropy inequality and thus long-time convergence. We establish the relation between CRTM and the confined Fokker–Planck model (CFPM) studied in [J. Fu, B. Perthame and M. Tang, Fokker–Plank system for movement of micro-organism population in confined environment, J. Statist. Phys. 184 (2021) 1–25]. We prove theoretically that when the tumble is highly forward peaked and frequent enough, CRTM converges asymptotically to the CFPM. A numerical comparison of the CRTM with aggregation and CFPM is given. The time evolution of both the deterministic PDE model and individual-based stochastic simulations are displayed, which match each other well.
Translational Aspects of Epithelioid Sarcoma: Current Consensus
Authors: Grünewald Thomas G.P. , Postel-Vinay Sophie , Nakayama Robert T. , Berlow Noah E. , Bolzicco Andrea , Cerullo Vincenzo , Dermawan Josephine K. , Frezza Anna Maria , Italiano Antoine , Jin Jia Xiang , Le Loarer Francois , Martin-Broto Javier , Pecora Andrew , Perez-Martinez Antonio , Tam Yuen Bun , Tirode Franck , Trama Annalisa , Pasquali Sandro , Vescia Mariagrazia , Wortmann Lukas , Wortmann Michael , Yoshida Akihiko , Webb Kim , Huang Paul H. , Keller Charles , Antonescu Cristina R. 
Published: November 2023

Abstract
Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ∼50% of cases despite aggressive multimodal therapies combining surgery, chemotherapy, and irradiation. EpS is traditionally classified in a more common, less aggressive distal (classic) type and a rarer aggressive proximal type. Both subtypes are characterized by a loss of nuclear INI1 expression, most often following homozygous deletion of its encoding gene, SMARCB1—a core subunit of the SWI/SNF chromatin remodeling complex. In 2020, the EZH2 inhibitor tazemetostat was the first targeted therapy approved for EpS, raising new hopes. Still, the vast majority of patients did not benefit from this drug or relapsed rapidly. Further, other recent therapeutic modalities, including immunotherapy, are only effective in a fraction of patients. Thus, novel strategies, specifically targeted to EpS, are urgently needed. To accelerate translational research on EpS and eventually boost the discovery and development of new diagnostic tools and therapeutic options, a vibrant translational research community has formed in past years and held two international EpS digital expert meetings in 2021 and 2023. This review summarizes our current understanding of EpS from the translational research perspective and points to innovative research directions to address the most pressing questions in the field, as defined by expert consensus and patient advocacy groups.
Avalonian Bahaism
Authors: Rose Dell J. 
Published: November 2023

AbstractThis article considers the thought of Wellesley Tudor Pole, one of Britain’s most important modern religious teachers, and his particular take on the Bahá’i faith. Pole’s ‘Bahaism,’ sought to present the teachings of ʿAbdu’l-Bahá and the other Bahá’i prophets as compatible with a constellation of different esoteric ideologies, which he felt would be at the centre of a world-wide spiritual revival. Pole also found in ʿAbdu’l-Bahá an Eastern teacher who he believed confirmed this new spiritual period, and he worked hard to promote ʿAbdu’l-Bahá and what he understood as being the Bahá’i faith, being for a time a major figure amongst nascentBahá’is in the West. His ideas were influential on the group of Esotericists around Glastonbury, known as the Avalonians, and his Chalice Well Trust is one of Britain’s most important centres of tourism.
Evaluation of the ICHD-3 diagnostic criteria for cardiac cephalalgia and new proposal
Authors: Navarro-Pérez María Pilar , Santos-Lasaosa Sonia , Olesen Jes 
Published: November 2023

Background The current International Classification of Headache Disorders, 3rd edition (ICHD-3) diagnostic criteria for cardiac cephalalgia were established according to previous case reports and the opinion of experts. We aimed to assess the ICHD-3 diagnostic criteria for cardiac cephalalgia. Methods We conducted a series of cases study and evaluated these criteria in 54 patients with cardiac cephalalgia. Next, we assessed whether the ICHD-3 diagnostic criteria B, C and D for migraine without aura were fulfilled by these patients. Results ICHD-3 criteria A, B, C1, C2 and D for cardiac cephalalgia were met by 100% of patients, whereas criterion C3 was fulfilled by 81.5%. The least frequently fulfilled sub-criterion was C3b (accompanied by nausea) (18.5%). Moreover, we found that ICHD-3 criteria B, C and D for migraine without aura were met by a low proportion of patients: 11.1%, 46.3% and 25.9%, respectively, and no patient fulfilled the three criteria simultaneously. Conclusion Based on our results, we propose revised diagnostic criteria for cardiac cephalalgia. We suggest removing criterion C3 and C4. We also suggest removing the word “migraine-like” from its description.
Preparation of CuO loaded cation exchange resin composites and its degradation of polyacrylamide aqueous solution
Authors: Wang Ying , Lai Zhiqing , Yang Xueying , Li Gang 
Published: November 2023

Macroporous cation exchange resins (CER) were used as carriers, and CuO loaded cation exchange resin composites was successfully prepared under thermostatic oscillation and hydrothermal conditions. The results showed that the as-prepared composites exhibited obvious shell-core structure. The different amounts of NaOH affected the micro morphology of CuO on the surface and in the internal pores of the resin, and also affected the percentage content of Cu element. XRD characterization clearly revealed that the products were monoclinic crystal system CuO species with a grain size of about 16 nm. The highest degradation rate of polyacrylamide (PAM) by CuO@IER-1g reached 81.94%, after 6 cycles CuO@CER-1g has still good photocatalytic activity, and the decrease in degradation rate was the combined effect from the adsorption of ion exchange resins and the electron-hole pairs formed by CuO and a series of free radical transfer reactions under ultraviolet light. This study has important theoretical basis and practical significance for enriching ion exchange theory, developing the photocatalytic industry, and purifying the environment.
Functional relation between postural sway and saccadic eye movements is strong and not altered by moving visual environment and concomitant memory task
Authors: Belizário Brito Matheus , Gotardi Gisele Chiozi , Rodrigues Sérgio Tosi , Jacomassi Daniela Godoi , Bonnet Cédrick T , Polastri Paula Fávaro 
Published: November 2023

We investigated whether the adaptation of postural control to perform saccadic tasks is still maintained in challenging situations such as when the posture is challenged with a large movement of the moving room and with the addition of a second perturbation as a visual task of memorization. Thirty young adults (20.0 ± 1.3 years) were randomly assigned to the control and experimental groups. Participants stood upright on a force plate inside a moving room wearing eye-tracking. The room moved back and forth (anterior–posterior direction), at low (.6 cm—first and third trials) and high (3.5 cm—second trial) amplitude, and frequency of .2 Hz. In each trial, participants performed left-right horizontal saccades on a target (1.1 Hz). The experimental group also performed a concomitant number memorization task. There were no differences between groups in the coupling between center of pressure (CoP) displacements and visual stimulus in any condition. There was also no difference in the performance of the saccadic task. In the memorization task, CoP displacements in response to the visual stimulus frequency (room motion) were not affected. The performance in the memorization task was similar between room conditions. Overall, increasing cognitive involvement by adding a working memory task does not deteriorate the postural stabilization of young adults to accomplish accurate gaze shifts. Also, it does not interfere with adaptive visual reweighting due to changes in the moving room amplitude. In conclusion, young adults are flexible in optimizing their postural control to succeed in multiple tasks even under perturbation.
“Keep Your Chin Up, and Keep Eating”: Perceptions of Barriers and Facilitators to Healthful Dietary Behaviors Among Individuals With Gastrointestinal Cancer and Caregivers
Authors: Milliron Brandy-Joe , Klobodu Cynthia , Deutsch Jonathan , Martyn Karon , Dychtwald Dan , Riahi Emily , Carro Shawn , Hisek Taylor , Darcy Natalie , Klassen Ann C 
Published: November 2023

Background This study explored perceptions of barriers and facilitators to healthful dietary behaviors among patients with gastrointestinal (GI) cancer and their caregivers, including caregiver preparedness, patient and caregiver self-efficacy for symptom management, and other environmental, social, and familial factors that may serve as barriers and facilitators to healthful eating. Methods Using a concurrent mixed methods cross-sectional study design, individuals with GI cancer receiving outpatient chemotherapy and their caregivers completed surveys, dietary assessments, and interviews. Caregiving preparedness, self-efficacy for symptom management, and dietary intake were assessed using validated instruments. Dietary quality was measured using the Healthy Eating Index (HEI)-2020. In-depth interviews explored barriers and facilitators to healthful eating, symptom management, and caregiver preparedness. Results Twenty-seven patient-caregiver dyads completed study activities (N = 54). Dietary quality scores ranged from 26 to 81, with a median score of 43 for patients and 42 for caregivers. Thematic analysis identified three barriers to healthful eating: caregiver self-efficacy and preparedness, caregiver needs are neglected, and nutrition as a source of conflict. Overall self-efficacy scores (Mdn, [IQR]) were 69.1 (45.0) for caregivers and 75.6 (34.1) for patients. Caregiver preparedness score was 2.99 ± .87; problem areas were identified, including addressing emotional needs, fluctuating eating habits, advanced disease progression and making care activities pleasant. Despite the challenges, three main facilitators were identified: increased awareness and value of nutrition, influential others, and positive coping. Conclusion Our findings suggest the importance of developing interventions that increase nutrition-related preparedness among caregivers and self-efficacy for managing treatment side effects. Future research should continue to explore the relationship between positive coping and dietary behaviors. While engaging patients and caregivers together during dietary interventions is a promising modality, strategies for maintaining personal nutrition-related goals when facing contrasting priorities between patients and caregivers should be addressed.
Suicidal ideation and attempts among adolescents from a tertiary hospital in Turkey: A comparative study of pre and postpandemic periods
Authors: Erdem Torun Şeyma , Pehlivantürk Kızılkan Melis , Derman Orhan , Akgül Sinem 
Published: November 2023

Aim This study aims to compare changes in rates of suicidal ideation (SI) and attempts (SA) among adolescents during pre, mid and later periods of the pandemic. Material and Method This study included adolescents who presented to the adolescent medicine clinic in Turkey between March-May 2019 (prepandemic = T0), March-May 2021(mid period of the pandemic = T1) and March-May 2022 (late period year of the pandemic = T2). SI and SA data were assessed through the electronic hospital records of the “HEEADSSS” inventory. Results The charts of 2113 adolescents were evaluated. The rates of both SI ( p = .015) and SA ( p = .026) were determined to be higher during the pandemic (T1+T2) compared to the pre-pandemic period, with a 1.4-fold increase in SI and a 1.5-fold increase in SA. The rates of SI did not differ according to gender, ( p = .090). In contrast, SA rate was significantly higher in females (7.3%) than males (3.6%) ( p = .001). Conclusion This study reveals an increase in SI and SA among adolescents during the first 2 years of the pandemic. In challenging times, health professionals should prioritize the identification and treatment of mental health issues, including screening for depression and suicide risk.
Disease course and psychosocial outcome for children and adolescents with anti-N-methyl-D-aspartate receptor encephalitis
Authors: Depreitere Joke , Antrop Inge , Verhelst Helene 
Published: November 2023

Objectives Explore psychosocial outcome and impact of persisting deficits on quality of life (QoL) and global functioning after anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) in children and adolescents. Methods Four female patients (age 7-16y) and their caregivers participated in the study. Information was collected from the medical records and the caregivers via a questionnaire. Both the patients and their caregivers were interviewed by means of the structured clinical interview for DSM-5 disorders, junior version (SCID-5 junior). CGAS and mRS scores were defined and the Pediatric Quality of Life Inventory (PedsQL) was used to assess quality of life of patients and caregivers. Results and conclusion After the acute phase of the disease patients go through a post-acute phase in which several persisting physical, cognitive and psychiatric symptoms gradually resolve during the following months to a year. In long-term follow up these symptoms partly resolved, but deficits persisted on several domains. Psychiatric symptoms, fatigue and mild cognitive deficits were present in three out of four patients at current assessment. In three patients their academic trajectory was altered. These deficits can have an impact on the quality of life and the global functioning of the patients and caregivers.