bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competencies for sustainability: Insights from the encyclical letter Laudato Si
Authors: Díaz de la Cruz Cristina , Polo Valdivieso Rubén Eduardo 
Published: November 2023

AbstractThis study offers a proposal about which competencies should be fostered in organizations to promote a culture in favor of sustainability in line with Pope Francis' encyclical letter Laudato Si. As a result, seven main competencies are proposed, with their interpretation in the light of the encyclical letter, and some suggestions on how to implement them in organizations are presented. The competencies are systemic vision, critical thinking, capacity for dialog, inclusion, proper use of goods, creativity, and spirituality. In addition, the study offers a discussion of the relevance of these competencies in today's business context. This study offers a novelty with respect to other theoretical proposals on competencies for sustainability since it includes competencies that require an authentic concern for other people and for a vision of the human being open to transcendence, thus breaking with instrumentalism and technocratic paradigm that underlies other proposals. In this way, it also offers a new key to interpreting the integral ecology proposed by Pope Francis, which goes beyond other approaches to sustainability in that it includes not only the person–nature relationship but also the person–person and person–transcendence or person–God relationships. The conclusions of this theoretical research can be especially useful for those who intend to promote a culture of sustainability inspired by the Catholic Social Teaching, also making use of the knowledge and good practices of competency‐based management.
ZPR1 is an immunodiagnostic biomarker and promotes tumor progression in esophageal squamous cell carcinoma
Authors: Sun Guiying , Ye Hua , Liu Huijuan , Li Tiandong , Li Jiaxin , Zhang Xiaoyue , Cheng Yifan , Wang Keyan , Shi Jianxiang , Dai Liping , Wang Peng 
Published: November 2023

AbstractTo evaluate the potential of zinc finger protein 1 (ZPR1) as a diagnostic biomarker and explore the underlying role for esophageal squamous cell carcinoma (ESCC). A human proteome microarray was customized to identify anti‐ZPR1 autoantibody, and enzyme‐linked immunosorbent assay (ELISA) was adopted to assess the diagnostic performance of anti‐ZPR1 autoantibody in 294 patients with ESCC and 294 normal controls. The expression of ZPR1 protein was measured by immunohistochemistry. The effect of ZPR1 on the proliferation, migration, and invasion of ESCC cells was investigated through CCK‐8, wound healing, and Transwell assays. The expression level of anti‐ZPR1 autoantibody (fold change = 2.77) in ESCC patients was higher than that in normal controls. The receiver operating characteristic (ROC) analysis manifested anti‐ZPR1 autoantibody achieved area under the ROC curve (AUC) of 0.726 and 0.734 to distinguish ESCC from normal controls with sensitivity of 50.0% and 42.3%, and specificity of 91.0% and 92.0% in the test group and validation group, respectively. The positive rate of ZPR1 protein was significantly higher in ESCC tissues (75.5%, 80/106) than paracancerous tissues (9.4%, 5/53). Compared with the human normal esophageal cell line, the expression level of ZPR1 mRNA and protein in ESCC lines (KYSE150, Eca109, and TE1) had an increased trend. The knockdown or overexpression of ZPR1 reduced and enhanced the proliferation, migration, and invasion of ESCC cell, respectively. ZPR1 was a potential immunodiagnostic biomarker for noninvasive detection and could be a promotional factor in tumor progression of ESCC.
‘I don't know what is autism, what is normal teenage behaviour, and what is naughtiness’: Conceptualising child and adolescent to parent violence in the context of neurodevelopmental difference
Authors: Holt Amanda 
Published: November 2023

AbstractThis article presents findings from a UK‐based qualitative study that explored parents/carers experiences of child to parent violence (CPV) from their child who has a neurodevelopmental difference. The study used semi‐structured interviews with 15 mothers who were experiencing physical and psychological violence from their child, often on a daily basis. Findings show that parents struggled to make sense of the violence, often feeling conflicted between whether the violence was the result of their child's neurodevelopmental challenges, ‘normal’ teenage behaviour or, in some cases, their child's poor mental health. Parents also recognised the inappropriateness of common advice they were given to address CPV. The implications of these complex sense‐making practices are discussed in relation to future research and practice.
Non‐allelic recombination interactive genetic algorithms for colour imagery reproduction in colour scheming
Authors: Liu Xiaojian , Li Ming , Xu Boqun 
Published: November 2023

AbstractUsing image extracted colours as the colour source for product colour matching is a common design strategy. The process of colour scheme design involves both source colour combination optimisation and continuous variable optimisation. As a commonly used optimising tool, interactive genetic algorithm (IGA) recombines the colours between alleles, that is, the same area in different colour schemes. Two types of invalid schemes are prone to arise during optimisation. The first is the colour duplication in a colour scheme's areas, which are supposed to be painted differently. The second is the unexpected new colours generated through interpolation between alleles. This article proposes a non‐allelic IGA (NA‐IGA) method, which allows colour recombination among non‐alleles, to avoid invalid schemes and improve algorithm efficiency. The crossover, evaluation, and selection operators are redesigned. NA‐IGA tries to maintain the features of extracted colours in the colour schemes while taking user preference into consideration. Thus, interaction methods for colour matching optimisation are designed to extend the evaluation mode of traditional IGA, including colour shuffling, continuous fine‐tuning, and so forth. An application test is conducted in the rail vehicle's painting design. The comparison experiment with traditional IGA shows that NA‐IGA significantly reduces the generation of invalid schemes and significantly improves efficiency and effectiveness of the optimisation.
Post‐transplant outcomes and financial burden of donation after circulatory death donor liver transplant after the implementation of acuity circle policy
Authors: Shimada Shingo , Yoshida Atsushi , Abouljoud Marwan , Miyake Katsunori , Ivanics Tommy , Shamaa Tayseer , Venkat Deepak , Moonka Dilip , Trudeau Sheri , Reed Elizabeth , Nagai Shunji 
Published: November 2023

AbstractBackgroundAfter implementation of the Acuity Circles (AC) allocation policy, use of DCD liver grafts has increased in the United States.MethodsWe evaluated the impact of AC on rates of DCD‐liver transplants (LT), their outcomes, and medical costs in a single practice. Adult LT patients were classified into three eras: Era 1 (pre‐AC, 1/01/2015–12/31/2017); Era 2 (late pre‐AC era, 1/01/2018–02/03/2020); and Era 3 (AC era, 05/10/2020–09/30/2021).ResultsA total of 520 eligible LTs were performed; 87 were DCD, and 433 were DBD. With each successive era, the proportion of DCD increased (Era 1: 11%; Era 2: 20%; Era 3: 24%; p < .001). DCD recipients had longer ICU stays, higher re‐admission/re‐operation rates, and higher incidence of ischemic cholangiopathy compared to those with DBD. Direct, surgical, and ICU costs during first admission were higher with DCD than DBD (+8.0%, p < .001; +4.2%, p < .001; and +33.3%, p = .001). DCD‐related costs increased after Era 1 (Direct: +4.9% [Era 2 vs. 1] and +12.4% [Era 3 vs. 1], p = .04; Surgical: +17.7% and +21.7%, p < .001). In the AC era, there was a significantly higher proportion of donors ≥50 years, and more national organ sharing. Compared to DCD from donors <50 years, DCD from donors ≥50 years was associated with significantly higher total direct, surgical, and ICU costs (+12.6%, p = .01; +9.5%, p = .01; +84.6%, p = .03).ConclusionsThe proportion of DCD‐LT, especially from older donors, has increased after the implementation of AC policies. These changes are likely to be associated with higher costs in the AC era.
Otolith microchemistry combined with genetics reveal patterns of straying and population connectivity in anadromous brown trout (Salmo trutta)
Authors: Källo Kristi , Birnie‐Gauvin Kim , Baktoft Henrik , Bekkevold Dorte , Lesher Charles , Grønkjær Peter , Barfod Gry H. , Johnson Rachel , Whitman George , Willmes Malte , Glessner Justin , Aarestrup Kim 
Published: November 2023

AbstractSalmonids are well known for their natal homing behaviour, meaning they return to breed in the same area where they originated. However, not all individuals return to their natal breeding grounds—a behavioural trait known as straying. The prevalence of straying is difficult to explore and therefore quantitative estimates for straying are seldom reported. In this study, otolith microchemistry and genetics were combined to investigate patterns of straying over ecological and evolutionary time, respectively, between neighbouring rivers flowing into Mariager fjord, Denmark. Otolith microchemistry was used to determine the river of origin for sea trout (Salmo trutta) upon their return to freshwater and 288 SNP markers were used to determine genetic structure among the rivers in the fjord. In this system, where the distance between rivers is short, otolith microchemistry achieved 80% accuracy in assigning juvenile brown trout to their natal river, thus allowing us to determine that approximately 43% of the adult sea trout had returned to non‐natal rivers to spawn, with a similar proportion of strayers and natal homers in all of the rivers. Genetic analysis further supported that there was substantial gene flow among individuals originating from different rivers, indicating that sea trout in Mariager fjord make up one population. The findings obtained from otolith microchemistry and genetics complement each other and provide further evidence that sea trout in this system migrate to non‐natal rivers and spawn there, which consequently affects the genetic structure of the population.
Severe vitamin D deficiency increases the risk of severe cutaneous adverse reactions
Authors: Pholmoo Natthiya , Thaiwat Supitchaya , Klaewsongkram Jettanong 
Published: November 2023

AbstractVitamin D deficiency has been reported to be associated with allergic diseases and dermatological disorders. We investigated the role of vitamin D in drug‐induced non‐immediate hypersensitivity reactions by measuring serum vitamin D levels in 60 patients diagnosed with non‐immediate drug hypersensitivity reactions and in 60 patients who tolerated the same medication without any allergic reactions. The results showed that serum vitamin D levels were significantly lower in patients with severe cutaneous adverse reactions (SCARs) (13.56 ± 6.23 ng/mL) compared to patients with mild reactions (17.50 ± 7.49 ng/mL) and the drug‐tolerant control group (17.42 ± 7.28 ng/mL), with p values of 0.031 and 0.015, respectively. The proportion of severe vitamin D deficiency (< 10 ng/mL) was much higher in SCAR patients compared to drug‐tolerant subjects (36.7% vs. 11.7%, p value = 0.005). After adjusting for age, gender, region of residence, and concurrent illnesses, patients with severe vitamin D deficiency had significantly increased in‐hospital mortality (odds ratio 16.04; 95% CI, 1.25–206.12, p value = 0.03). In conclusion, the risk of developing SCARs and in‐hospital mortality was increased in patients with severe vitamin D deficiency. Further investigations should be conducted to elucidate the role of vitamin D in the development of SCARs.
Drainage ditches are year‐round greenhouse gas hotlines in temperate peat landscapes
Authors: Hendriks Lisanne , Weideveld Stefan , Fritz Christian , Stepina Tatiana , Aben Ralf C. H. , Fung Ngum E. , Kosten Sarian 
Published: November 2023

Abstract

Greenhouse gas (GHG) emissions from drained peatlands have been studied extensively. Considerably less attention has been paid to the emissions from the ditches used to drain peatlands. High within‐ditch GHG production and lateral inflow of GHGs may lead to ditches emitting considerable amounts of GHGs on the landscape scale.

We quantified annual emissions of ebullitive and diffusive methane (CH4), carbon dioxide (CO2), and nitrous oxide (N2O) in 10 drainage ditches in intensively used temperate peatlands used for dairy farming, in The Netherlands. Additionally, we assessed water and sediment quality to determine proxies for emissions via the two emission pathways.

The mean annual emissions from the studied ditches varied between 3.57 and 60.1 g CO2‐eq. m−2 day−1 (based on a global warming potential over a 100‐year timeframe), where CO2 contributed on average 43% (ranging between 1.9 and 22.0 g CO2 m−2 day−1) and diffusive CH4 contributed 16% (0.1–16.5 g CO2‐eq. m−2 day−1) to the total GHG emission. Ebullition of CH4 made up nearly half of the total GHG emission (40%, 1.3–40.9 g CO2‐eq. m−2 day−1). N2O emissions were mostly low. CO2 emissions were higher in winter months, while CH4 ebullition was higher during spring and summer. Diffusive CH4 emissions did not show a seasonal pattern.

The mean emission factor, the estimate of average emissions per unit area (EF), for CH4 was 2144 kg CH4 ha−1 year−1, which is two times higher than the tier 1 EF reported by the IPCC (with underrepresented ebullition data), underlining the high variability of ditch emissions.

Ditch emissions were also higher than the EF used for the surrounding drained peatlands indicating that ditch emissions can be important on the landscape scale and should be considered to be included in national greenhouse gas reporting.
The PKM2 inhibitor shikonin enhances piceatannol‐induced apoptosis of glyoxalase I‐dependent cancer cells
Authors: Inoue Manami , Nakagawa Yuki , Azuma Miku , Akahane Haruka , Chimori Ryusei , Mano Yasunari , Takasawa Ryoko 
Published: November 2023

AbstractGlyoxalase I (GLO I), a major enzyme involved in the detoxification of the anaerobic glycolytic byproduct methylglyoxal, is highly expressed in various tumors, and is regarded as a promising target for cancer therapy. We recently reported that piceatannol potently inhibits human GLO I and induces the death of GLO I‐dependent cancer cells. Pyruvate kinase M2 (PKM2) is also a potential therapeutic target for cancer treatment, so we evaluated the combined anticancer efficacy of piceatannol plus low‐dose shikonin, a potent and specific plant‐derived PKM2 inhibitor, in two GLO I‐dependent cancer cell lines, HL‐60 human myeloid leukemia cells and NCI‐H522 human non‐small‐cell lung cancer cells. Combined treatment with piceatannol and low‐dose shikonin for 48 h synergistically reduced cell viability, enhanced apoptosis rate, and increased extracellular methylglyoxal accumulation compared to single‐agent treatment, but did not alter PKM1, PKM2, or GLO I protein expression. Taken together, these results indicate that concomitant use of low‐dose shikonin potentiates piceatannol‐induced apoptosis of GLO I‐dependent cancer cells by augmenting methylglyoxal accumulation.
Simultaneous enhancement of friction and wear resistance for high‐speed braking system with Cr3C2‐NiCr‐coated brake disk
Authors: Wen Yuying , Zhang Youyuan , Zhang Xinhao , Yan Qingzhi 
Published: November 2023

AbstractThe current steel brake disk and Cu‐based powder metallurgy brake pad used in high‐speed trains suffer fading coefficient of friction (COF) and excessive wear, resulting in a shorten lifetime and numerous exhausted brake disks. High‐velocity oxygen fuel (HVOF) spray‐prepared coatings have proven their ability to improve COF and decrease wear rate. In this article, Cr3C2‐NiCr coating was sprayed on a steel brake disk, and a series of emergency braking tests under dry and wet conditions were performed on a subscale brake dynamometer, to comprehensively evaluate the braking performance of coated brake disk. The results showed that the coated brake disk exhibits a higher COF at 380 km/h, which effectively inhibits the COF fade compared to the steel brake disk case. The coated brake system also achieves a lower wear rate of the brake pad at 380 km/h, showing the desired high COF and low wear rate properties of the braking system. Additionally, the coated brake disk maintained surface integrity even after severe braking tests, highlighting its potential in the braking system. Based on the characterizations of wear debris and brake pads, a harder and thinner oxide friction film plays a crucial role in achieving the excellent braking performance in coated brake disk cases.
Learning Chinese in a study abroad context: The case of ritual congratulating
Authors: House Juliane , Kádár Dániel Z. 
Published: November 2023

AbstractIn this paper, we explore how and why the realisation of the ritual act of congratulating may turn out to be challenging for foreign learners of Chinese. Congratulating and other ceremonial ritual acts are not only used when someone participates in an actual ritual event: they are also required when they are mentioned in mundane events, like casual interactions when someone talks about a family birthday or wedding. We define congratulation as an interactional move and systematically examine its conventional realisation patterns through a typology of speech acts. We approach congratulating moves by combining a speech act‐anchored analysis with the field of study abroad and interaction ritual research. The results of our analysis show that various ritual occasions may trigger different types of inappropriate uses of congratulating by foreign learners of Chinese.
Comparison of the frailty index and frailty phenotype and their associations with postoperative delirium incidence and severity
Authors: Deiner Stacie G. , Marcantonio Edward R. , Trivedi Shrunjal , Inouye Sharon K. , Travison Thomas G. , Schmitt Eva M. , Hshieh Tammy , Fong Tamara G. , Ngo Long H. , Vasunilashorn Sarinnapha M. 
Published: November 2023

AbstractBackgroundRecent studies have reported an association between presurgical frailty and postoperative delirium. However, it remains unclear whether the frailty‐delirium relationship differs by measurement tool (e.g., frailty index vs. frailty phenotype) and whether frailty is associated with delirium, independent of preoperative cognition.MethodsWe used the successful aging after elective surgery (SAGES) study, a prospective cohort of older adults age ≥70 undergoing major non‐cardiac surgery (N = 505). Preoperative measurement of the modified mini‐mental (3MS) test, frailty index and frailty phenotype were obtained. The confusion assessment method (CAM), supplemented by chart review, identified postoperative delirium. Delirium feature severity was measured by the sum of CAM‐severity (CAM‐S) scores. Generalized linear models were used to determine the relative risk of each frailty measure with delirium incidence and severity. Subsequent models adjusted for age, sex, surgery type, Charlson comorbidity index, and 3MS.ResultsOn average, patients were 76.7 years old (standard deviation 5.22), 58.8% of women. For the frailty index, the incidence of delirium was 14% in robust, 17% in prefrail, and 31% in frail patients (p < 0.001). For the frailty phenotype, delirium incidence was 13% in robust, 21% in prefrail, and 27% in frail patients (p = 0.016). Frailty index, but not phenotype, was independently associated with delirium after adjustment for comorbidities (relative risk [RR] 2.13, 95% confidence interval [CI] 1.23–3.70; RR 1.61, 95% CI 0.77–3.37, respectively). Both frailty measures were associated with delirium feature severity. After adjustment for preoperative cognition, only the frailty index was associated with delirium incidence; neither index nor phenotype was associated with delirium feature severity.ConclusionBoth the frailty index and phenotype were associated with the development of postoperative delirium. The index showed stronger associations that remained significant after adjusting for baseline comorbidities and preoperative cognition. Measuring frailty prior to surgery can assist in identifying patients at risk for postoperative delirium.
The presence of a foramen of Luschka in the American alligator (Alligator mississippiensis) and the continuity of the intraventricular and subdural spaces
Authors: Taylor Ethan , Cramberg Michael , Parker Seth , Scott Anchal , Sopko Stephanie , Swords Annelise , Young Bruce A. 
Published: November 2023

AbstractIn humans and most mammals, there is a notch‐like portal, the foramen of Luschka (or lateral foramen), which connects the lumen of the fourth ventricle with the subdural space. Gross dissection, light and scanning electron microscopy, and μCT analysis revealed the presence of a foramen of Luschka in the American alligator (Alligator mississippiensis). In this species, the foramen of Luschka is a notch in the dorsolateral wall of the pons immediately caudal to the peduncular base of the cerebellum, near the rostral end of the telovelar membrane over the fourth ventricle. At the foramen of Luschka there was a transition from a superficial pia mater lining to a deep ependymal lining. There was continuity between the lumen of the fourth ventricle and the subdural space, via the foramen of Luschka. This anatomical continuity was further demonstrated by injecting Evans blue into the lateral ventricle which led to extravasation through the foramen of Luschka and pooling of the dye on the lateral surface of the brain. Simultaneous subdural and intraventricular recordings of cerebrospinal fluid (CSF) pressures revealed a stable agreement between the two pressures at rest. Perturbation of the system allowed for static and dynamic differences to develop, which could indicate varying flow patterns of CSF through the foramen of Luschka.
Plant virus‐derived nanoparticles decorated with genetically encoded SARS‐CoV‐2 nanobodies display enhanced neutralizing activity
Authors: Merwaiss Fernando , Lozano‐Sanchez Enrique , Zulaica João , Rusu Luciana , Vazquez‐Vilar Marta , Orzáez Diego , Rodrigo Guillermo , Geller Ron , Daròs José‐Antonio 
Published: November 2023

SummaryViral nanoparticles (VNPs) are a new class of virus‐based formulations that can be used as building blocks to implement a variety of functions of potential interest in biotechnology and nanomedicine. Viral coat proteins (CP) that exhibit self‐assembly properties are particularly appropriate for displaying antigens and antibodies, by generating multivalent VNPs with therapeutic and diagnostic potential. Here, we developed genetically encoded multivalent VNPs derived from two filamentous plant viruses, potato virus X (PVX) and tobacco etch virus (TEV), which were efficiently and inexpensively produced in the biofactory Nicotiana benthamiana plant. PVX and TEV‐derived VNPs were decorated with two different nanobodies recognizing two different regions of the receptor‐binding domain (RBD) of the SARS‐CoV‐2 Spike protein. The addition of different picornavirus 2A ribosomal skipping peptides between the nanobody and the CP allowed for modulating the degree of VNP decoration. Nanobody‐decorated VNPs purified from N. benthamiana tissues successfully recognized the RBD antigen in enzyme‐linked immunosorbent assays and showed efficient neutralization activity against pseudoviruses carrying the Spike protein. Interestingly, multivalent PVX and TEV‐derived VNPs exhibited a neutralizing activity approximately one order of magnitude higher than the corresponding nanobody in a dimeric format. These properties, combined with the ability to produce VNP cocktails in the same N. benthamiana plant based on synergistic infection of the parent PVX and TEV, make these green nanomaterials an attractive alternative to standard antibodies for multiple applications in diagnosis and therapeutics.