bluuebunny/crossref_metadata_2025_split huggingface dataset:
The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer
Authors: Valente Ingrid V. Bonilla , Garcia Denise , Abbott Andrea , Spruill Laura , Siegel Julie , Forcucci Jessica , Hanna George , Mukherjee Rupak , Hamann Mark , Hilliard Eleanor , Lockett Mark , Cole David J. , Klauber-DeMore Nancy 
Published: January 2024

Abstract
Purpose
Boswellic acids, active components of frankincense, suppress tumor proliferation in vitro with a strong clinical trial safety profile in patients with inflammatory diseases. We performed a Phase Ia window of opportunity trial of Boswellia serrata (B. serrata) in patients with breast cancer to evaluate its biologic activity and safety.

Methods
Patients with invasive breast cancer were treated pre-operatively with B. Serrata (2400 mg/day PO) until the night before surgery for a median of 11 days (SD 6 days; range: 5–23 days). Paraffin-embedded sections from pretreatment diagnostic core biopsies and post-treatment surgical excisions were evaluated using a tunnel assay and immunohistochemistry staining with Ki-67 antibodies. A non-intervention retrospective control arm consisting of core and surgical tissue specimens from untreated patients was used to compare patients treated with B. Serrata. The change in proliferation and apoptosis between diagnostic core specimens and surgical specimens was compared between the control and treatment groups using a two-tailed paired t-test.

Results
Twenty-two patients were enrolled, of which 20 received treatment, and 18 had sufficient tissue for IHC. There was an increase in percent change in proliferation from core biopsy to surgical excision in the control group (n = 18) of 54.6 ± 21.4%. In the B. serrata-treated group there was a reduction in proliferation between core biopsy and excision (n = 18) of 13.8 ± 11.7%. This difference was statistically significant between the control and B. serrata-treated groups (p = 0.008). There was no difference in change in apoptosis. There were no serious adverse events related to the drug.

Conclusion
Boswellia serrata inhibited breast cancer proliferation and was well-tolerated in a Phase Ia window of opportunity trial.
Organising Food Systems Through Ecologies of Care: A Relational Approach
Authors: Pavlovich Kathryn , Roche Maree 
Published: January 2024

AbstractConcerns over the organising of food are widespread, stemming from unsustainable production practices that focus on extractive ‘use’ of resources that privilege wealth creation over planetary flourishing, care and well-being. We propose a conceptual framework based on ecologies of care to assist in the re-entanglement of food systems. The concept of ecologies of care brings together theoretical understandings of relationality, ecology and care, along with an Aotearoa New Zealand indigenous Māori perspective. We examine how food production can be underpinned by interdependent webs of relationships (whanaungatanga), stewardship (kaitiakitanga), and care and support (manaakitanga) with healthy land and healthy people at the core of organising.
Relative effectiveness of simulation games, blended learning, and interactive multimedia in basic science achievement of varying ability pupils
Authors: Adeyele Victoria Olubola 
Published: January 2024

AbstractThe study determined the relative effectiveness of simulation games, blended learning, and interactive multimedia in enhancing learning outcomes in Basic Science of pupils with varying abilities, with a view to providing information on the most effective strategy for instructing Basic Science among pupils with varying abilities. Children should be exposed to and commence learning science at a young age because science and technology are the dynamic forces behind present socioeconomic progress. The research design employed was a quasi-experimental research design. The experiment was conducted in six schools, and two schools were used as the control group. The analysis used descriptive and inferential statistics. Permission was sought from the Local Government Education Authorities (LGEA) to use the schools in their jurisdictions for the experiment. Participants were given a consent form for their parents. Pseudonyms were used to replace participants’ names. The findings indicate that interactive multimedia is more effective with pupils in mainstream schools, whereas blended learning proves more effective for pupils in special schools. These findings imply that teachers should employ strategies to captivate and maintain attention while teaching Basic Science.
Atmospheric Degradation of Ecologically Important Biogenic Volatiles: Investigating the Ozonolysis of (E)-β-Ocimene, Isomers of α and β-Farnesene, α-Terpinene and 6-Methyl-5-Hepten-2-One, and Their Gas-Phase Products
Authors: Touhami Dalila , Mofikoya Adedayo O. , Girling Robbie D. , Langford Ben , Misztal Pawel K. , Pfrang Christian 
Published: January 2024

AbstractBiogenic volatile organic compounds (bVOCs), synthesised by plants, are important mediators of ecological interactions that can also undergo a series of reactions in the atmosphere. Ground-level ozone is a secondary pollutant generated through sunlight-driven reactions between nitrogen oxides (NOx) and VOCs. Its levels have increased since the industrial revolution and reactions involving ozone drive many chemical processes in the troposphere. While ozone precursors often originate in urban areas, winds may carry these hundreds of kilometres, causing ozone formation to also occur in less populated rural regions. Under elevated ozone conditions, ozonolysis of bVOCs can result in quantitative and qualitative changes in the gas phase, reducing the concentrations of certain bVOCs and resulting in the formation of other compounds. Such changes can result in disruption of bVOC-mediated behavioural or ecological interactions. Through a series of gas-phase experiments using Gas Chromatography Mass Spectrometry (GC-MS) and Proton Transfer Reaction Mass Spectrometry (PTR-MS), we investigated the products and their yields from the ozonolysis of a range of ubiquitous bVOCs, which were selected because of their importance in mediating ecological interactions such as pollinator and natural enemy attraction and plant-to-plant communication, namely: (E)-β-ocimene, isomers of α and β-farnesene, α-terpinene and 6-methyl-5-hepten-2-one. New products from the ozonolysis of these compounds were identified, and the formation of these compounds is consistent with terpene-ozone oxidation mechanisms. We present the degradation mechanism of our model bVOCs and identify their reaction products. We discuss the potential ecological implications of the degradation of each bVOC and of the formation of reaction products.
Perceptions of Electability: Candidate (and Voter) Ideology, Race, and Gender
Authors: Hassell Hans J. G. , Visalvanich Neil 
Published: January 2024

AbstractPrevious work has shown candidate electability is an important consideration to voters in deciding who to support. However, we do not know what candidate qualities voters consider more electable, especially in the absence of polling information. While scholarship has documented general election penalties for candidates with certain demographic and ideological characteristics, we do not know whether voters actually use these factors when judging electability. Using a conjoint experimental design, we examine how candidate characteristics influence perceptions of candidate electability. We find voters perceive women and minorities as less electable and ideologically extreme candidates as more electable. However, perceptions of electability vary with voter characteristics. Our results indicate that arguments about electability, for many individuals, are based on their own ideological preferences (and to a lesser extent, their identity) rather than systematically viewing candidates with attributes that provide general election advantages as more electable.
The Scientific Calibration of the Dawn Framing Camera
Authors: Kovács Gábor , Nathues Andreas , Sierks Holger , Gutiérrez Marqués Pablo , Hoffmann Martin , Thangjam Guneshwar Singh 
Published: January 2024

AbstractNASA’s Dawn mission visited the large main-belt asteroids Ceres and Vesta, returning a rich data set. Its science and navigation cameras, Framing Cameras 1 and 2, provided more than 100,000 surface images in total of both targets with seven colour and one panchromatic channels. This paper summarizes the scientific calibration of the Framing Camera images, combining information from on-ground and in-flight calibration campaigns. We describe the calibration methods, algorithms, and parameters that led to the final level 1c data product, including correcting stray light sources. In addition, we detail the performance and stability of both instruments.
The Uranus Multi-Experiment Radiometer for Haze and Clouds Characterization
Authors: Apéstigue V. , Toledo D. , Irwin P. G. J. , Rannou P. , Gonzalo A. , Martínez-Oter J. , Ceballos-Cáceres J. , Azcue J. , Jiménez J. J. , Sebastian E. , Yela M. , Sorribas M. , de Mingo J. R. , Martín-Ortega A. , Belenger T. , Alvarez M. , Vázquez-García de la Vega D. , Espejo S. , Arruego I. 
Published: January 2024

AbstractThe aerosols (clouds and hazes) on Uranus are one of the main elements for understanding the thermal structure and dynamics of its atmosphere. Aerosol particles absorb and scatter the solar radiation, directly affecting the energy balance that drives the atmospheric dynamics of the planet. In this sense, aerosol information such as the vertical distribution or optical properties is essential for characterizing the interactions between sunlight and aerosol particles at each altitude in the atmosphere and for understanding the energy balance of the planet’s atmosphere. Moreover, the distribution of aerosols in the atmosphere provides key information on the global circulation of the planet (e.g., regions of upwelling or subsidence).To address this challenge, we propose the Uranus Multi-experiment Radiometer (UMR), a lightweight instrument designed to characterize the aerosols in Uranus’ atmosphere as part of the upcoming Uranus Flagship mission’s descending probe payload. The scientific goals of UMR are: (1) to study the variation of the solar radiation in the ultra-violet (UV) with altitude and characterize the energy deposition in the atmosphere; (2) to study the vertical distribution of the hazes and clouds and characterize their scattering and optical properties; (3) to investigate the heating rates of the atmosphere by directly measuring the upward and downward fluxes; and (4) to study the cloud vertical distribution and composition at pressures where sunlight is practically negligible (p > 4-5 bars).The instrument includes a set of photodetectors, field-of-view masks, a light infrared lamp, and interference filters. It draws on the heritage of previous instruments developed at the Instituto Nacional de Técnica Aeroespacial (INTA) that participated in the exploration of Mars, where similar technology has demonstrated its endurance in extreme environments while utilizing limited resources regarding power consumption, mass and volume footprints, and data budget. The radiometer’s design and characteristics make it a valuable complementary payload for studying Uranus’ atmosphere with a high scientific return.
Interaction domains for capacity- and performance-based design of pile groups
Authors: Cesaro Raffaele , Di Laora Raffaele , Iodice Chiara , Mandolini Alessandro 
Published: January 2024

AbstractThe aim of the paper is to propose design tools for pile groups when vertical and moment loads are applied simultaneously. This is done by presenting a method to derive the exact solution for the failure locus in the generalized force space, including a vertical load and a moment with components along two axes, to employ for capacity requirements which helps to get rid of overconservative assumptions usually adopted in design. Moreover, closed-form solutions for performance-based interaction domains are also provided allowing to detect all the combinations of external loads associated with a given value of settlement and/or rotation of the foundation that is extremely useful when the design is ruled by serviceability requirements. The application of these straightforward formulae provides results which are in very good agreement with the more rigorous solutions derived from a numerical procedure developed ad hoc for the problem at hand.
Validation of a small-scale method for determination of phosphorus in meat and meat products by molecular absorption spectroscopy
Authors: Fernandes Élia , Barros Mário , Pires Preciosa 
Published: January 2024

AbstractThe purpose of this study was to evaluate the applicability of an alternative analytical technique to the reference method for phosphorus detection in meat and meat products established by ISO 2294:1974, revised by ISO 23776:2021. When an analytical method is modified or a new one is developed and implemented, it should be validated before being accepted for routine determinations. Furthermore, it is necessary to demonstrate that the new or alternative method has good performance characteristics in comparison with the reference method. Therefore, a comparison of the performance of the alternative and the reference method should be made. In the present study, a statistical evaluation of the calibration model of the alternative method was made with data from interlaboratory studies made in five consecutive years using fifty analyses of meat and meat products. The statistical parameters evaluated over time for the calibration curve were the y-intercept and slope; correlation and linearity; analytical limits: detection and quantification; working range; and accuracy (precision and trueness). In the interlaboratory tests, the results obtained by the alternative analytical method were compared with those obtained by the reference method, and their performance in these tests was also evaluated. The results obtained by the alternative method indicated better accuracy than the reference method due to lower relative errors, more precision, and a good trueness evaluation through lower absolute values of the z-score. The study demonstrated that the phosphorus alternative method is applicable for the determination of total phosphorus in the matrix of meat and meat products.
Prognostic value of high-sensitivity cardiac troponin in non-cardiac surgical patients in intensive care units
Authors: Sivarajah Jitain , Toolis Michael , Seminoff Samantha , Smith Jesse , Bhalla Vikram , Paul Eldho , Tiruvoipati Ravindranath 
Published: January 2024

AbstractType II myocardial injury following surgical procedures is associated with adverse outcomes. The prognostic value of high-sensitivity cardiac troponin (hs-cTn) due to type II myocardial injury in surgical patients admitted to intensive care unit (ICU) remains unclear. The aim of this study was to assess prognostic value of hs-cTn in type II acute myocardial injury in non-cardiac surgical patients requiring post-operative ICU admission. Retrospective analysis of patients admitted to two level III ICUs following surgery and had hs-cTn measured on the day of ICU admission. Patients who had type I acute myocardial infarction (AMI) during their admission were excluded from the study. The primary outcome was hospital mortality. Secondary outcomes included ICU mortality, ICU length of stay (LOS) and hospital LOS. A total of 420 patients were included. On univariable analysis, higher hs-cTn was associated with increased hospital mortality (14.6% vs 6.3%, p = 0.008), ICU LOS (41.1 h, vs 25 h, p = 0.004) and hospital LOS (253 h vs 193 h, p = 0.02). On multivariable analysis, hs-cTn was not independently associated with increased risk of hospital mortality. However, in patients who had elective surgery, hs-cTn was associated with increased risk (OR 1.048; 95% CI 1.004–1.094; p = 0.031) of hospital mortality with area under the receiver operating characteristic curve of 0.753 (95% CI 0.598–0.908). In elective surgical patients, hs-cTn was associated with increased risk of mortality. Larger multicentre studies are required to confirm this association that may assist in risk stratification of elective surgical patients requiring ICU admission.
Treatment of Richter’s Transformation with Novel Therapies
Authors: Bajwa Amneet , Habib Alma , Kittai Adam S. 
Published: January 2024

Abstract
Purpose of Review
This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter’s transformation (RT).

Recent Findings
Recently, numerous approaches have been investigated for the treatment of RT including: traditional chemoimmunotherapy regimens combined with targeted agents such as BTKi and BCL2i; immunotherapy combined with targeted agents; non-covalent BTKis; bispecific T cell engagers; and CART therapy. In addition, various novel targeted agents are currently being studied for the treatment of RT in phase 1 and 2 clinical trials.

Summary
Standard of care treatment with chemoimmunotherapy for RT has limited efficacy in achieving durable remissions. Here, we review recent data on the use of combination treatments and targeted agents in RT. Although some progress has been made in the investigation to optimize treatment of RT, further study is needed to evaluate long term outcomes of recently published trials and test efficacy of upcoming novel agents.
Functional Properties of Moringa Oleifera Protein Isolates as Influenced by Different Isolation Techniques, pH, and Ionic Strength
Authors: Illingworth Kirsty A. , Lee Yee Ying , Siow Lee Fong 
Published: January 2024

AbstractPlant-based proteins are increasingly being utilized as they are sustainable, economical, and can enhance the organoleptic properties of food products. This study investigated the effect of extraction and isolation techniques (alkaline extraction & isoelectric precipitation and salt extraction & micellization) on the functional properties ((solubility, water holding and oil absorption capacity (WHC/OAC), emulsifying activity and stability index (EAI/ESI), foaming capacity and stability (FC/FS), and gelation)) of Moringa oleifera protein isolates. The effect of ionic strength (0.2–1.0 M NaCl) and pH (2–10) on the functional properties were also investigated. Salt extraction & micellization produced an isolate with a high solubility at 0.8 M NaCl and pH 10 (98.1%, 91.8%), EAI at 0.6 M NaCl and pH 6 (56.2 m2/g, 77.0 m2/g), and ESI at 0.8 M NaCl and pH 4 (64.4 min, 243.5 min). Alkaline extraction & isoelectric precipitation resulted in an isolate with a high WHC at 0.6 M NaCl and pH 10 (5.8 g/g, 4.0 g/g), OAC (4.9 g/g), FC at 0.4 M NaCl and pH 2 (203.3%, 163.3%), and gelation at 0.2 M NaCl, 0.4 M NaCl, and pH 8 (20.0%). Both extraction methods can be applied in the valorization of M. oleifera seedcake. Micellized isolate could be used in food emulsions due to better emulsifying properties, while isoelectric isolate can be applied in meats and sauces, owing to better water holding and oil absorption capacity. M. oleifera protein isolates are promising plant-based proteins that can be used in food formulations or to replace animal-derived proteins in food.
Potential of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Fruit, Kernel, and Pomace as Promising Functional Ingredients for the Development of Food Products: A Comprehensive Review
Authors: Mo Jianling , Rashwan Ahmed K. , Osman Ahmed I. , Eletmany Mohamed R. , Chen Wei 
Published: January 2024

AbstractChinese bayberry (Myrica rubra Sieb. et Zucc.) fruit (CBF) is widely growing in eastern Asia, mainly in China. CBFs contain a high number of polyphenols, especially anthocyanins. However, CBF can be easily damaged and cannot be stored for more than 3 days at 20–22 °C and 9–12 days at 0–2 °C. Thus, this review explores the potential options for the long-term preservation and consumption of CBFs, as well as the importance of CBF by-products. The review also addressed the biological activity of CBFs and their food products. The consumption period of CBF can be increased by employing a variety of processing techniques, including rapid freezing, drying, juicing, making wine and vinegar, and adding it to meals. Additionally, oil and bioactive substances can be extracted from the CBF by-products, such as kernel and pomace. The greatest options to extend the duration of CBF ingestion are thought to be CBF powder, juice, and wine. Furthermore, CBFs and their derivatives exhibit many biological activities such as antibacterial, anticancer, antidiabetic, and antioxidant properties. The two biological activities that were most potent were antidiabetic and antioxidant. However, more biological research, particularly clinical-based research, is advised to investigate the potential health benefits of CBF and its products.
Are prolactin levels efficient in predicting a pituitary lesion in patients with hyperprolactinemia?
Authors: Varaldo Emanuele , Cuboni Daniela , Prencipe Nunzia , Aversa Luigi Simone , Sibilla Michela , Bioletto Fabio , Berton Alessandro Maria , Gasco Valentina , Ghigo Ezio , Grottoli Silvia 
Published: January 2024

Abstract
Purpose
Data regarding the presence of a prolactin (PRL) threshold above which a pituitary magnetic resonance imaging (MRI) is mandatory in patients with hyperprolactinemia (hyperPRL) are controversial and derived primarily from studies focused on female populations. Aim of our study was to evaluate in a cohort of patients of both sexes with confirmed hyperPRL, the possible correlation between PRL values and the presence of pituitary abnormalities.

Methods
We retrospectively analyzed data from patients who underwent serial PRL sampling at our Division between January 2015 and December 2022. Patients diagnosed with monomeric hyperPRL at serial sampling and with subsequent contrast-enhanced MRI results available for the pituitary region were included in the study. Exclusion criteria were prior pituitary disease, severe renal insufficiency, liver cirrhosis, uncompensated primary hypothyroidism and ongoing therapy with hyperprolactinemic drugs. Physiological causes of hyperPRL were also ruled out.

Results
Out of the 1253 patients who underwent serial PRL sampling, 139 patients (101 women and 38 men) met the inclusion criteria: 106 (76.3%) patients had some form of pituitary disease, with microlesions observed in 69.8%, macrolesions in 25.5% and other findings in 4.7% of subjects. PRL values showed a modest accuracy in predicting the presence of a pituitary abnormality and the best cut-offs identified were >25 µg/L (AUC 0.767, p = 0.003) and >44.2 µg/L (AUC 0.697, p < 0.001) in men and women, respectively; however, if only patients with PRL values > 500 µg/L were excluded from the analysis, as they were already supposed to harbor a macroprolactinoma, PRL levels were not able to predict the presence of a macrolesion neither in men nor women.

Conclusion
Given the high prevalence of pituitary abnormalities in patients of both sexes with hyperPRL at serial sampling, performing a pituitary imaging in all cases of hyperPRL, even if mild, appears to be a cautious choice.