bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of social recommendation algorithm integrating attention model in movie recommendation
Authors: Cui Pengjia , Yin Boshi , Xu Baichuan 
Published: October 2023

AbstractTo improve the accuracy of recommendations, alleviate sparse data problems, and mitigate the homogenization of traditional socialized recommendations, a gated recurrent neural network is studied to construct a relevant user preference model to mine user project preferences. Through the Preference Attention Model Based on Social Relations (PASR), this study extracts user social influence preferences, performs preference fusion, and obtains a Recommendation Algorithm Based on User Preference and Social Influence (UPSI). The study demonstrates that the UPSI algorithm outperforms other methods like the SocialMF algorithm, yielding improved recommendation results, higher HR values, and larger NDCG values. Notably, when the K value equals 25 in Top-K recommendation and using the CiaoDVDs dataset, the NDCG value of the UPSI algorithm is 0.267, which is 0.120 higher than the SocialMF algorithm's score. Considering the user's interaction with the project and their social relationships can enhance the effectiveness of recommendations. Unlike other variants, the UPSI algorithm achieves a maximum hit rate HR value of 0.3713 and NDCG value of 0.2108 in the Douban dataset. In the CiaoDVDs dataset, the maximum hit rate HR value of UPSI is 0.4856, 0.0333 higher than UPS-A, 0.0601 higher than UPS, and 0.0901 higher than UP. Research methods can effectively improve the homogenization problem of traditional socialized recommendations, increase algorithm hit rates and NDCG values. Compared to previous studies, research methods can more fully explore the preference correlation between users, making recommended movies more in line with user requirements.
Research on escalators used as evacuation stairs under fire scenarios
Authors: Zhang Chunhua , Wu Xin , Chen Jinquan , Shen Hai 
Published: October 2023

AbstractShopping malls are crowded areas which makes the evacuation routes unable to meet personnel evacuation needs. Therefore, this paper proposes the idea of using escalators evacuation to increasing evacuation routes. In addition, the effects of escalator fire shutters on the use of escalator evacuation paths, and the efficiency of mall personnel evacuation under different conditions were simulated. The results show that the different states of fire shutters have different effects on the emergency evacuation. When the fire shutter is not lowered, it will result in 1 person not being evacuated to complete. However, when the fire shutter is lowered to 1.8 m from the ground or sprinklers are set, escalators can be used for evacuation routes are verified. And compared to the normal descent of the fire shutter (only the staircase evacuation, 2 people not evacuate completed), the evacuation of people is completed and the efficiency of evacuation is improved. This result can improve the new evacuation model for emergency evacuation plans of shopping malls with escalators.
Effects of various extraocular muscle enlargement patterns on muscle diameter index in graves ophthalmopathy patients: a retrospective cohort study
Authors: Yang Junjie , Chen Jin , Shi Bingjie , You Yayan , Pi Xiaohuan , Zhao Guang , Jiang Fagang 
Published: October 2023

AbstractGraves ophthalmopathy (GO) patients often undergo retrobulbar injection of glucocorticoids (GCs) as a common therapeutic approach. This study aimed to explore the impact of various patterns of extraocular muscle (EOM) enlargement on EOM changes following retrobulbar GCs injection in patients with GO. A retrospective analysis was conducted on GO patients who underwent retrobulbar GCs injections. Data pertaining to EOM diameter (EMD) and muscle diameter index (MDI) were collected from orbital computed tomography (CT) scans. The MDI change (ΔMDI) was calculated by comparing pre- and post-injection MDI values. The relationship between each pre EMD/MDI and ΔMDI was assessed using univariate and multivariate logistic regression analysis. A total of 68 patients with GO were included in this study, accounting for 118 eyes. After retrobulbar injections of GCs, 84 eyes showed a decrease in the MDI, while 34 eyes exhibited an increase in MDI. A threshold effect was observed in the relationship between medial pre EMD/MDI and ΔMDI. When the medial pre EMD/MDI was less than 0.28, a higher medial pre EMD/MDI was associated with a smaller ΔMDI (β = − 25.21, p = 0.0175). However, when the medial pre EMD/MDI was greater than 0.28, no significant association was found between pre EMD/MDI and ΔMDI. There was a negative correlation between medial + lateral pre EMD/MDI and ΔMDI (β = − 11.76, p < 0.0189). A higher medial + lateral pre EMD/MDI was associated with a greater decrease in MDI. Additionally, there was a positive correlation between superior rectus muscle-levator complex (SRLC) pre EMD/MDI and ΔMDI (β = 11.92, p = 0.040). The higher the value of SRLC pre EMD/MDI, the greater the ΔMDI. There was an association between pre EMD/MDI and changes in EOMs after retrobulbar injection of GCs in GO patients. In patients with predominantly enlarged medial rectus muscles and severe degrees of enlargement, retrobulbar injection of GCs should be assessed for its benefit; a combination of medial and lateral rectus muscle enlargement is beneficial for the shrinkage of EOMs following retrobulbar injections; the involvement of the SRLC rectus muscle may be a disadvantageous pattern of shrinkage of EOMs following retrobulbar injections.Trial registration This study is retrospectively registered. We have registered this study with the Chinese Clinical Trials Registry (www.chictr.org.cn, registration number: ChiCTR2200063429).
Multilingualism is associated with small task-specific advantages in cognitive performance of older adults
Authors: Achaa-Amankwaa Priscilla , Kushnereva Ekaterina , Miksch Hanna , Stumme Johanna , Heim Stefan , Ebersbach Mirjam 
Published: October 2023

AbstractThe protective effects of multiple language knowledge on the maintenance of cognitive functions in older adults have been discussed controversially, among others, because of methodological inconsistencies between studies. In a sample of N = 528 German monolinguals and multilinguals (speaking two or more languages) older than 60 years, this study examined (1) whether speaking multiple languages is positively related to performance on tasks of interference suppression, working memory, concept shifting, and phonemic and semantic fluency, and (2) whether language proficiency and age of second language acquisition (AoA) are associated with cognitive performance of multilinguals. Controlling for education and daily activity, we found small cognitive benefits of speaking multiple languages on interference suppression, working memory, and phonemic fluency, but not on concept shifting and semantic fluency. Furthermore, no substantive correlations were found between language proficiency or AoA and cognitive performance. In conclusion, multilingualism appears to have small incremental effects on cognitive performance beyond education and daily activity in older age that are task-specific and widely independent of proficiency and AoA.
Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia
Authors: Vitale Candida , Griggio Valentina , Todaro Maria , Riganti Chiara , Jones Rebecca , Boccellato Elia , Perutelli Francesca , Arruga Francesca , Vaisitti Tiziana , Efremov Dimitar G. , Deaglio Silvia , Landesman Yosef , Bruno Benedetto , Coscia Marta 
Published: October 2023

AbstractDespite recent relevant therapeutic progresses, chronic lymphocytic leukemia (CLL) remains an incurable disease. Selinexor, an oral inhibitor of the nuclear export protein XPO1, is active as single agent in different hematologic malignancies, including CLL. The purpose of this study was to evaluate the anti-tumor effects of selinexor, used in combination with chemotherapy drugs (i.e. fludarabine and bendamustine) or with the PI3Kδ inhibitor idelalisib in CLL. Our results showed a significant decrease in CLL cell viability after treatment with selinexor-containing drug combinations compared to each single compound, with demonstration of synergistic cytotoxic effects. Interestingly, this drug synergism was exerted also in the presence of the protective effect of stromal cells. From the molecular standpoint, the synergistic cytotoxic activity of selinexor plus idelalisib was associated with increased regulatory effects of this drug combination on the tumor suppressors FOXO3A and IkBα compared to each single compound. Finally, selinexor was also effective in potentiating the in vivo anti-tumor effects of the PI3Kδ inhibitor in mice treated with the drug combination compared to single agents. Our data provide preclinical evidence of the synergism and potential efficacy of a combination treatment targeting XPO1 and PI3Kδ in CLL.
Gapless edge states localized to odd/even layers of AA′-stacked honeycomb multilayers with staggered AB-sublattice potentials
Authors: Lee Kyu Won , Lee Cheol Eui 
Published: October 2023

AbstractIn honeycomb multilayers with staggered AB-sublattice potentials, we predict gapless edge states localized to either of the odd and the even layers for the AA$$^{\prime }$$

′

stacking order in which the sublattice-pseudospin polarizations of adjacent layers are antiparallel. Gaps in the projected layer-pseudospin spectrum suppress interlayer hopping between odd and even layers. The layer-valley Chern number corresponding to the edge states was obtained by decomposing the occupied state into two layer-pseudospin sectors by using a projected layer-pseudospin operator. For the AB$$^{\prime }$$

′

stacking, the sublattice-pseudospin polarizations of adjacent layers are antiparallel, but the layer-pseudospin spectrum gap closes at the interface of the topologically different states, leading to gapped edge states. For the AA and AB stackings where the sublattice-pseudospin polarizations of the adjacent layers are parallel, the gapless edge states corresponding to quantum valley Hall states are evenly distributed across the layers.
Impact of deoxygenation/reoxygenation processes on the superconducting properties of commercial coated conductors
Authors: Cayado Pablo , Bonura Marco , Lucas Celia , Saule Enora , Rijckaert Hannes , Bagni Tommaso , Konstantopoulou Konstantina , Alessandrini Matteo , Senatore Carmine 
Published: October 2023

AbstractWe report the evolution of the superconducting properties of a commercial coated conductor during deoxygenation and reoxygenation processes. By analyzing the changes on the critical temperature, Tc, and critical current density, Jc, at 4 and 77 K, we have identified the conditions that cause a complete deoxygenation of the coated conductor and, also, the reoxygenation conditions that allow a recovery of the superconducting properties. A complete suppression of superconductivity happens at ~ 500–550 °C under a pure argon flow. After a complete deoxygenation, we observed that a reoxygenation process at ~ 400–450 °C in pure oxygen flow allows, not only a full recovery, but even an improvement in Jc, both at 4 and 77 K. Such an increase of Jc is kept or even enhanced, especially at 77 K, in the presence of magnetic fields up to ~ 6 T. A microstructural analysis by transmission electron microscopy did not give evidence of major differences in the densities of Y2O3 nanoparticles and stacking faults between the pristine and reoxygenated samples, suggesting that these defects should not be the cause of the observed enhancement of Jc. Therefore, the combined action of other types of defects, which could appear as a consequence of our reoxygenation process, and of a new level of oxygen doping should be responsible of the Jc enhancement. The higher Jc that can be achieved by using our simple reoxygenation process opens new parameter space for CCs optimization, which means choosing a proper pO2-temperature–time trajectory for optimizing Jc.
GEFAAR: a generic framework for the analysis of antimicrobial resistance providing statistics and cluster analyses
Authors: Sandmann Sarah , Schaumburg Frieder , Varghese Julian 
Published: October 2023

AbstractEasy access to antimicrobial resistance data and meaningful visualization is essential to guide the empirical antimicrobial treatment and to promote the rational use of antimicrobial agents. Currently available solutions are commonly externally hosted, centralized systems. However, there is a need for close monitoring by local analysis tools. To fill this gap, we developed GEFAAR—a generic framework for the analysis of antimicrobial resistance data. Following the example of the German Robert Koch Institute (RKI), an interactive web-application is provided to determine basic pathogen and resistance statistics. In addition to the RKI’s externally maintained database, our application provides a generic framework to import tabular data and to analyze them safely in a local environment. Moreover, our application offers an intuitive web-based user interface to visualize resistance trend analysis as well as advanced cluster analyses on species- or clinic/unit level to generate alerts of potential transmission events.
Comparison of corneal measurements using two different Scheimpflug analyzers in Sirius and Pentacam devices
Authors: Abdi Parisa , Atighehchian Mehrnaz , Farsiani Amir Reza 
Published: October 2023

AbstractThe aim was to compare measurements of anterior segment biometry parameters using two Scheimpflug tomographies, Pentacam and Sirius to assess the agreement. Prospective cross-sectional observational study. A total of 60 eyes of 30 healthy subjects were included and evaluated with Pentacam followed by Sirius imaging. Corneal indices were performed with two modalities in both eyes including; apical corneal thickness (ACT), corneal thickness at pupil site(PCT), thinnest corneal thickness (TCT), anterior chamber depth (ACD), chamber angle, chamber volume, cornea volume, mean front keratometry (FKm), the radius of corneal curvature at the anterior and posterior surface in steep and flat meridian, anterior astigmatism values, pupil diameter, and horizontal corneal diameter. The Bland–Altman graph and ICC (intra-class correlation were used to establish an agreement and present the similarity of the findings. Most parameters showed perfect agreement. In both devices, the ICC was more than 0.91 in all measurements except for ACD (ICC = 0.820), cylinder axis (ICC = 0.520), TCT(ICC = 0.881), ACT(ICC = 0.672), PCT (ICC = 0.882), chamber angle (ICC = 0.362), pupil diameter(ICC = 0.137). Pentacam yielded higher values that were significant in five parameters including 3.47 μm for TCT, 4.29 µm for PCT, 10.03 mm3 for chamber volume,2.67 mm3 for cornea volume, and 1.49 mm for pupil diameter but there was only a statistically significant difference in cornea volume and pupil diameter (p-value < 0.001). However, in Pentacam only the chamber angle value was 6.44 mm3 lower than Sirius, with a statistically significant difference (p-value < 0.001). Although these two devices had some statistically different results, it seems that they have a good agreement and correlation in most parameters.
Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia
Authors: Cheng Kunrong , Chahdi Ahmed , Larabee Shannon M. , Tolaymat Mazen , Sundel Margaret H. , Drachenberg Cinthia B. , Zhan Min , Hu Shien , Said Anan H. , Shang Aaron C. , Xie Guofeng , Alizadeh Madeline , Moura Natalia Sampaio , Bafford Andrea C. , Williams Richelle T. , Hanna Nader N. , Raufman Jean-Pierre 
Published: October 2023

AbstractM3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico, in vitro, and in vivo approaches, we explored whether these actions are regulated by M3R. At the invasive fronts of murine and human colon cancers, we detected co-localized nuclear expression of βPix and β-catenin in stem cells overexpressing M3R. Using immunohistochemistry, immunoprecipitation, proximity ligand, and fluorescent cell sorting assays in human tissues and established and primary human colon cancer cell cultures, we detected time-dependent M3R agonist-induced cytoplasmic and nuclear association of βPix with β-catenin. βPix knockdown attenuated M3R agonist-induced human colon cancer cell proliferation, migration, invasion, and expression of PTGS2, the gene encoding cyclooxygenase-2, a key player in colon neoplasia. Overexpressing βPix dose-dependently augmented β-catenin binding to the transcription factor TCF4. In a murine model of sporadic colon cancer, advanced neoplasia was attenuated in conditional knockout mice with intestinal epithelial cell deficiency of βPix. Expression levels of β-catenin target genes and proteins relevant to colon neoplasia, including c-Myc and Ptgs2, were reduced in colon tumors from βPix-deficient conditional knockout mice. Targeting the M3R/βPix/β-catenin axis may have therapeutic potential.
Chimpanzees select comfortable nesting tree species
Authors: Lacroux Camille , Krief Sabrina , Douady Stéphane , Cornette Raphaël , Durand Sophie , Aleeje Alfred , Asalu Edward , Pouydebat Emmanuelle 
Published: October 2023

AbstractEvery evening, chimpanzees build sleeping “nests” in trees. In some studied communities, individuals appear to be selective about the tree species used, which has led researchers to hypothesize whether chimpanzees prefer trees that repel troublesome insects or/and that provide comfortable and stable structures. We investigate these hypotheses, or a trade-off between both, though study of tree species preference based on their biomechanical and/or biochemical properties in the Sebitoli chimpanzee community in Kibale National Park, Uganda. The ten tree species most frequently used for nesting were compared with ten abundant in their environment but not preferred for nesting. For these 20 tree species, we determined their biomechanical and morphological characteristics such as foliar density, foliar units form (shape and size) and branch rigidity. Their spatial repellent activity, previously tested against Anopheles gambiae was incorporated into the analysis. Chimpanzees chose tree species with medium-sized and elongated foliar units, high foliar density and branch with stiffer wood. In addition, most tree species with such mechanical and morphological properties also have mosquito repellent activity. These tree properties may provide a comfortable sleeping environment enhancing sleep quality. Finally, a comparison across chimpanzee communities would be relevant to understand whether these choices are not only ecological but also cultural.
Robust process capability indices Cpm and Cpmk using Weibull process
Authors: Kashif Muhammad , Ullah Sami , Aslam Muhammad , Iqbal Muhammad Zafer 
Published: October 2023

AbstractProcess Capability Indices (PCIs) are very helpful to measure the manufacturing capability and production quality of the products in many manufacturing processes. These PCIs are calculated by using a relationship between process mean and standard deviation, provided that process follows a normal distribution. In case of non-normal processes many researchers recommended the use of robust PCIs by modifying the classical PCIs. In case of robust PCIs most of the work is reported on first- and second-generation PCIs but less work is reported on third generation PCIs. The objective of this work was to evaluate the efficiency of three dispersion measures, namely median absolute deviation (MAD), interquartile range (IQR), and Gini's mean difference (GMD), as a measure of dispersion in third generation PCIs and construct their bootstrap confidence intervals (CIs). The efficacy of these measures is compared with quantile-based PCIs under different asymmetric behaviour of the Weibull process. The results showed that quantile-based PCIs are strongly influenced by high asymmetry and IQR method provides a poor estimator across all sample sizes. On the other hand, the GMD method performed well under low, moderate, and high asymmetry of the Weibull process, but its irregular behavior needs to be addressed carefully. Among all selected four methods MAD-method performed better under low and moderate asymmetric conditions. In case of interval estimation, bias-corrected percentile (BCPB) CIs was recommended for quantile-based PCIs, while percentile (PB) and percentile-t (PTB) CIs were recommended for MAD-based PCIs under all asymmetric conditions. To validate the simulated findings, two real-world datasets were analyzed that supported the simulation results.
Long-time irradiation effect on corrosion behavior of aluminum alloy in pool water of low-power research reactor
Authors: Bagherzadeh Mojtaba , Karimi Meysam , Choopan Dastjerdi Mohammad Hosein , Asadi Asadabad Mohsen , Mokhtari Javad , Babanejhad Afshin 
Published: October 2023

AbstractThis study conducted an evaluation of the corrosion behavior of an aluminum alloy utilized in the Isfahan Miniature Neutron Source Reactor (MNSR). The component analyzed, dry channel (DC), had been exposed to radiation for 12 years in a water environment within the reactor pool since its installation. To determine the effect of radiation on the corrosion of the LT-21 aluminum alloy used in the DC, different parts of the pipe were sampled and various tests were performed. These tests included mechanical strengths (impact, and micro-hardening), XRD, TEM, SEM–EDS, and potentiodynamic polarization (PDP). The parameters measured included corrosion potential, corrosion rate, changes in microscopic structure, and mechanical properties of the aluminum alloy along the entire length of the DC. The neutron and gamma dose distribution along the height of the DC, which was 540 cm, was calculated to determine the correlation between the dose distribution and observed corrosion. The study found that the corrosion mechanisms were complex and resulted from the simultaneous presence of the DC in the pool water and radiation from the reactor core. The observed results are presented and discussed in this study.
MCPIP1 functions as a safeguard of early embryonic development
Authors: Lichawska-Cieslar Agata , Szukala Weronika , Prajsnar Tomasz K. , Pooranachandran Niedharsan , Kulecka Maria , Dabrowska Michalina , Mikula Michal , Rakus Krzysztof , Chadzinska Magdalena , Jura Jolanta 
Published: October 2023

AbstractMonocyte chemoattractant protein-induced protein 1 (MCPIP1), also called Regnase-1, is an RNase that has been described as a key negative modulator of inflammation. MCPIP1 also controls numerous tumor-related processes, such as proliferation, apoptosis and differentiation. In this study, we utilized a zebrafish model to investigate the role of Mcpip1 during embryogenic development. Our results demonstrated that during embryogenesis, the expression of the zc3h12a gene encoding Mcpip1 undergoes dynamic changes. Its transcript levels gradually increase from the 2-cell stage to the spherical stage and then decrease rapidly. We further found that ectopic overexpression of wild-type Mcpip1 but not the catalytically inactive mutant form resulted in an embryonic lethal phenotype in zebrafish embryos (24 hpf). At the molecular level, transcriptomic profiling revealed extensive changes in the expression of genes encoding proteins important in the endoplasmic reticulum stress response and in protein folding as well as involved in the formation of primary germ layer, mesendoderm and endoderm development, heart morphogenesis and cell migration. Altogether, our results demonstrate that the expression of zc3h12a must be tightly controlled during the first cell divisions of zebrafish embryos and that a rapid decrease in its mRNA expression is an important factor promoting proper embryo development.