bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal associations between exclusive, dual and polytobacco use and respiratory illness among youth
Authors: Zavala-Arciniega Luis , Cook Steven , Hirschtick Jana , Xie Yanmei , Mukerjee Richa , Arenberg Douglas , Barnes Geoffrey D. , Levy David T. , Meza Rafael , Fleischer Nancy 
Published: January 2024

Abstract

Background
The health consequences of polytobacco use are still well not understand. We evaluated prospective associations between exclusive, dual, and polytobacco use and diagnosed bronchitis, pneumonia, or chronic cough among US youth.
Methods
Data came from Waves 1–5 of the Population Assessment of Tobacco and Health Study. We categorized time-varying past 30-day tobacco use into seven categories: (1) non-current use; exclusive use of 2) cigarettes, 3) electronic nicotine delivery systems (ENDS), or 4) other combustible products (OC; pipes, hookah, and cigars); dual use of 5) ENDS + cigarettes or ENDS + OC 6) cigarettes + OC; or 7) polyuse of all three products. The outcome was incident diagnosis of bronchitis, pneumonia, or chronic cough. We conducted weighted multilevel Poisson models (person n = 17,517, 43,290 observations) to examine the longitudinal exposure-outcome relationship, adjusting for covariates: sex, age, race and ethnicity, parental education, body mass index, secondhand smoke exposure, and household use of combustible products
Results
Compared to nonuse, exclusive cigarette use (Incidence Rate Ratio (IRR) = 1.83, 95% CI 1.25–2.68), exclusive ENDS use (IRR = 1.53, 95% CI 1.08–2.15), combustible product + ENDS dual use (IRR = 1.90, 95% CI 1.18–3.04), cigarettes + OC dual use (IRR = 1.96, 95% CI 1.11–3.48), and polytobacco use (IRR = 3.06 95% CI 1.67–5.63) were associated with a higher incidence of bronchitis, pneumonia, or chronic cough.
Conclusion
We found that exclusive, dual, and poly tobacco use was associated with higher incidence of bronchitis, pneumonia, or chronic cough; Moreover, the incidence rate ratio for polytobacco use was higher than the incidence rate ratio for exclusive use compared to non-current use.
Preparation and properties of Mg-Nd binary alloy MAO/SiO2@α-Fe2O3 organic composite coating
Authors: Jiang Quantong , Sun Qiang , Wu Siwei , Liu Chang , Tang Heng , Shi Hao , Song Liying , Duan Jizhou , Hou Baorong 
Published: January 2024

Abstract

An organic coating of about 40 mm was sprayed on the MAO coating containing Yb2O3. The main components of the organic coating are a mixture of SiO2 and α-Fe2O3 with mass ratios of 20%, 22.5% and 25%, and three different MAO/SiO2 @ α-Fe2O3 organic composite coatings are prepared. The morphology, roughness, microstructure and chemical composition of the organic composite coating are characterized. The results show that after coating the organic composite coating, the roughness of the coating is significantly reduced, and the compactness and interlayer adhesion of the coating are significantly improved. The electrochemical test and SKPFM test of the organic composite coating were carried out. The results showed that with the increase of the mass ratio of SiO2 and α-Fe2O3, the corrosion resistance and stability of the organic composite coating increased, and the Volta potential also gradually moved up. The microwave absorbing properties of organic composite coatings were studied by vector network analyzer. The results show that the microwave absorbing properties of the coatings are positively correlated with the mass ratio of SiO2 and α-Fe2O3.
Plasmodium vivax severe malaria case in a children patient in Saint- Louis, Senegal
Authors: Sow Doudou , Sall Aminata , Lo Aminata , Makalou Demba , Lodholz Sara , Esser Markus , Demarta-Gatsi Claudia , Ndiaye Jean Louis Abdourahim 
Published: January 2024

Abstract
Background: Infections caused by Plasmodium vivax are underestimated in Sub-Saharan Africa. Several cases have been reported in recent years including in Duffy-negative individuals. Most of the cases are uncomplicated, however severe infections can occur with sometimes poor outcomes. Here, we report the first case of Plasmodium vivax severe infection reported in the north of Senegal.
Case presentation: MDD, 12 years old female patient aged has been received at the hospital for fever, abdominal pain and vomiting. The physical examination has revealed a jaundice and a hepatomegaly. The ultrasound exam has confirmed a hepatomegaly and splenomegaly. The biological examination has revealed a severe anemia (Hb=5.5 g/dl), a low level of platelets (92 103 /mm3). The thick and thin blood film yielded negative result at the admission. However, 10 days after hospitalization, the microscopic parasitological examination yielded for the first-time positive result for Plasmodium with parasite density at 660 trophozoites/mL. The medical staff has retained the diagnosis of severe malaria and started the treatment with artesunate. The control of the Giemsa-stained blood smear done several days after was still positive. A first real time PCR has revealed the diagnosis of Plasmodium vivax and the primaquine has been added to the treatment.
The case was confirmed by a sequencing method which has revealed three single nucleotide polymorphisms (SNPs). Among these SNPs, two have never been described before.
Conclusion: This report has shown the presence of Plasmodium vivax in the north of Senegal which shared a border with Mauritania, an endemic Plasmodium vivax setting. Suggesting a need to improve the surveillance of this pathogen in Senegal and surrounding regions.
Metabolomic profiling of cancer-related fatigue involved in cachexia and chemotherapy
Authors: Okinaka Yuki , Kageyama Susumu , Goto Toshiyuki , Sugimoto Masahiro , Tomita Atsumi , Aizawa Yumi , Kobayashi Kenichi , Wada Akinori , Kawauchi Akihiro , Kataoka Yosky 
Published: January 2024

Abstract

Patients with advanced cancer are frequently burdened with a severe sensation of fatigue called cancer-related fatigue (CRF). CRF is induced at various stages and treatments, such as cachexia and chemotherapy, and reduces the overall survival of patients. Objective and quantitative assessment of CRF could contribute to the diagnosis and prediction of treatment efficacy. However, such studies have not been intensively performed, particularly regarding metabolic profiles. Here, we conducted plasma metabolomics of 15 patients with urological cancer. The patients with and without fatigue, including those with cachexia or chemotherapy-induced fatigue, were compared. Significantly lower concentrations of valine and tryptophan were observed in fatigued patients than in non-fatigued patients. In addition, significantly higher concentrations of polyamine pathway metabolites were observed in patients with fatigue and cachexia than in those without cachexia. Patients with exacerbated fatigue due to chemotherapy showed significantly decreased cysteine and methionine metabolism before chemotherapy compared with those without fatigue exacerbation. These findings suggest that plasma metabolic profiles could help improve the diagnosis and monitoring of CRF.
Systematic review and meta-analysis: Pharmacological and nonpharmacological interventions for disruptive mood dysregulation disorder
Authors: zhang Yuhan , Zhang Wenxuan 
Published: January 2024

Abstract

Background
Disruptive mood dysregulation disorder (DMDD) is a relatively new diagnostic approach that focuses on describing severe, non-episodic irritability and recurrent outbursts of emotional instability in adolescents.
Methods
This meta-analysis examined the efficacy of the available pharmacological and nonpharmacological interventions for DMDD. Literature searches were conducted in July 2023. To determine relevant papers, 330 abstracts were reviewed, and 39 articles were identified for full review. A random-effects model was used for the meta-analysis, and a subgroup analysis was used to assess the effects of study design and intervention type. Eleven studies were included (six pharmacological and five nonpharmacological).
Results
Despite high heterogeneity in effects (I²=85%), we showed statistically significant improvement to irritability symptoms following intervention (standardized mean difference = 0.78, 95% confidence interval = 0.21–1.36, Z = 2.68, P༜0.05). The subgroup analysis showed that, compared with randomized controlled trials (RCTs), participants in open trials showed significant improvement in irritability. Additionally, drug intervention significantly improved irritability compared to non-drug interventions. Atomoxetine, optimized stimulants, or stimulants combined with other drugs and behavioral therapy effectively improved irritability. However, large-sample RCTs are needed to explore DMDD treatment without potential influencing factors.
Conclusion
In conclusion, treatment strategies for persistent non-periodic irritability in youths with DMDD are diverse, and because of DMDD symptoms and its intersection with other diseases, it is necessary to combine multiple treatment strategies.
Design of Power Efficient Analog to Digital Converter
Authors: Malathi D , Nandha T , Nithish S , Naresh S P 
Published: January 2024

Abstract
Analog to Digital Converters (ADCs) plays a critical role in modern electronic systems, enabling the conversion of continuous analog signals into digital representations which require low power consumption and high conversion efficiency. The demand for low- power electronic devices continue to grow; efficient ADCs play a crucial role in power- sensitive applications. The design and comparative analysis of three distinct ADC architectures, namely Flash, Successive Approximation Register (SAR), and Sub ranging, all implemented in a 180nm Complementary Metal Oxide Semiconductor (CMOS) technology with a focus on achieving low power consumption. The Flash ADC, known for its high-speed conversion in a single step, is examined in terms of power efficiency, especially as it relates to its suitability for high-speed applications. The SAR ADC, characterized by its iterative approximation process, is assessed for its power consumption during precise conversions. Subranging ADCs, combining speed and resolution through multi- stage conversion, are analyzed for their power efficiency and effectiveness in balancing these attributes. The average power of the three ADCs with resolution of 4 bits is compared. From the existing ADC average power is reduced 25% for Flash, 36% for SAR and 34% for Subranging ADC and the most effective architecture is Subranging ADC with an average power of 3.125 mW.
Diffusion Model-based Probabilistic Downscaling for 180-year East Asian Climate Reconstruction
Authors: Luo Jing-Jia , Ling Fenghua , Lu Zeyu , Bai Lei , Behera Swadhin , Jin Dachao , Pan Baoxiang , Jiang Huidong , Yamagata Toshio 
Published: January 2024

Abstract

As our planet is entering into the “global boiling” era, understanding regional climate change becomes imperative. Effective downscaling methods that provide localized insights are crucial for this target. Traditional approaches, including computationally-demanding regional dynamical models or statistical downscaling frameworks, are often susceptible to the influence of downscaling uncertainty. Here, we address these limitations by introducing a diffusion probabilistic downscaling model (DPDM) into the meteorological field. This model can efficiently transform data from 1° to 0.1° resolution. Compared with deterministic downscaling schemes, it not only has more accurate local details, but also can generate a large number of ensemble members based on probability distribution sampling to evaluate the uncertainty of downscaling. Additionally, we apply the model to generate a 180-year dataset of monthly surface variables in East Asia, offering a more detailed perspective for understanding local scale climate change over the past centuries.
Investigation on acoustic emission characteristics of fault stick-slip under different lateral pressures
Authors: Ding Ling , Zhao Yangfeng , Pan Yishan , Fan Yi 
Published: January 2024

Abstract

To explore the effect of different stress environments on fault-slip rockburst. The bidirectional shear friction experiments with different lateral pressures were conducted on pre-cracked syenogranites buried at 800m. The macroscopic statistical parameters (cumulative AE events, magnitude and b value) and local characteristic parameters (amplitude and dominant frequency) of acoustic emission during the stick-slip process under different lateral pressures were investigated. Besides, based on the fractal theory, the nonlinear characteristics of AE wave and its spectrum were analyzed. On this basis, the microscopic mechanism of fault stick-slip was discussed. The results show that the lateral pressure influences the friction strength of the fault and stick-slip characteristics. With the increase of lateral pressure, the proportion of transgranular shear fracture is increased, which leads to the increase of cumulative AE events and magnitude. The periodic decrease of b value is more significant at high lateral pressure. There is a good correlation between the high-magnitude AE event and the stress drop. The box-counting fractal dimension of AE waveform can reﬂect the difference of energy released during fault stick-slip. The AE frequency with phased response characteristics can effectively identify the evolution of the fault stick-slip instability at the laboratory scale. The sharp increase in the amplitude of dominant frequency can be regarded as one of the precursory features of fault stick-slip instability. AE frequency spectra have multifractal characteristics, which are different in different stages. The maximum multifractal dimension and spectral width can reﬂect the fracture scale of asperities.
Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in non-human primates
Authors: Dehay Benjamin , Sikora Joanna , Dovero Sandra , Kinet Rémi , Arotcarena Marie-Laure , Bohic Sylvain , Bezard Erwan , Fernagut Pierre-Olivier 
Published: January 2024

Abstract

Lysosomal impairment is strongly implicated in Parkinson's disease (PD). Among the several PD-linked genes, the ATP13A2 gene, associated with the PARK9 locus, encodes a transmembrane lysosomal P5-type ATPase that acts as a lysosomal polyamine exporter. Mutations in the ATP13A2 gene were primarily identified as the cause of Kufor-Rakeb syndrome (KRS), a juvenile-onset form of PD. Subsequently, an increasing list of several homozygous and compound-heterozygous mutations has been described. These mutations result in truncation of the ATP13A2 protein, leading to a loss of function but surprisingly causing heterogeneity and variability in the clinical symptoms associated with different brain pathologies. In vitro studies show that its loss compromises lysosomal function, contributing to cell death. To understand the role of ATP13A2 dysfunction in disease, we disrupted its expression through a viral vector-based approach in nonhuman primates. Here, in this pilot study, we injected bilaterally into the substantia nigra of macaque monkeys, a lentiviral vector expressing an ATP13A2 small hairpin RNA. Animals were terminated five months later, and brains were harvested to evaluate cerebral pathological markers known to be affected in KRS and PD. We characterised the pattern of dopaminergic loss in the striatum and the substantia nigra, the regional distribution of α-synuclein immunoreactivity in several brain structures, and its pathological status (i.e., S129 phosphorylation), the accumulation of heavy metals in nigral sections and occurrence of lysosomal dysfunction. Our findings show that lentivirus-mediated ATP13A2 silencing can induce significant and ongoing degeneration in the nigrostriatal pathway, α-synuclein pathology, and iron accumulation in nonhuman primates.
Seasonal migration patterns of Siberian Rubythroat (Calliope calliope) facing the Qinghai-Tibet Plateau
Authors: Zhao Tianhao , Heim Wieland , Nussbaumer Raphaël , Toor Mariëlle van , Zhang Guoming , Andersson Arne , Bäckman Johan , Liu Zongzhuang , Song Gang , Hellström Magnus , Roved Jacob , Liu Yang , Bensch Staffan , Wertheim Bregje , Lei Fumin , Helm Barbara 
Published: January 2024

Abstract

Background
Small songbirds respond and adapt to various geographical barriers during their annual migration. Global flyways reveal the various migration strategies in response to different geographical barriers, among which are high-elevation plateaus. However, few studies have been focused on the largest and highest plateau in the world, the Qinghai-Tibet Plateau (QTP) which poses a significant barrier to migratory passerines. The present study explored the annual migration routes and strategies of a population of Siberian Rubythroats (Calliope calliope) that breed on the north-eastern edge of the QTP.
Methods
Over the period from 2021 to 2023, we applied light-level geolocators (n = 13), archival GPS tags (n = 45), and CAnMove multi-sensor loggers (with barometer, accelerometer, thermometer, and light sensor, n = 20) to the breeding population of Siberian rubythroat on QTP. Here we describe the migratory routes and phenology extracted or inferred from the logger data, and used a combination of accelerometric and barometric data to describe the elevational migration pattern, flight altitude, and flight duration.
Results
Both GPS locations and positions derived from pressure-based inference both revealed that during autumn, the migration route detoured from the bee-line between breeding and wintering grounds, leading to a gradual elevational decrease. The spring route was more direct, with more flights over mountainous areas in western China. This different migration route during spring probably reflects a strategy for a faster migration, which corresponds with more frequent long nocturnal migration flights and shorter stopovers during spring migration than in autumn. The average flight altitude (2000 m above sea level) was correlated with ground elevation but did not differ between the seasons.
Conclusions
Our finding indicates the strong impact of the Qinghai-Tibet Plateau on shaping passerine migration strategies. We hereby call for more attention to the unexplored central-China flyway to extend our knowledge on the environment-migration interaction among small passerines.
Construction of a prognostic model based on cuproptosis-related genes and exploration of the value of DLAT and DLST in the metastasis for non-small cell lung cancer
Authors: Ma Huiying , Li Yuhong , Wang Tingting , Ge Yizhi , Chen Wei 
Published: January 2024

Abstract
Objective
To reveal the clinical value of cuproptosis-related genes on prognosis and metastasis in non-small cell lung cancer.
Method
Gene expression profiles and clinical information of non-small cell lung cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The data were grouped into training set, internal testing set, and external testing set. A risk prognostic model was constructed by Lasso-Cox regression analysis. Hub genes were identified and evaluated using immunohistochemistry and the Transwell migration assay in 50 clinical patients.
Results
A total of 17/19 cuproptosis-related genes were differentially expressed in tumors, 8 were significantly associated with prognosis, and 4 were markedly associated with metastasis. A risk model based on two cuproptosis-related genes was constructed and validated for predicting overall survival. The risk score was proven to be an independent risk factor for the prognosis of non-small cell lung cancer. DLAT and DLST, key genes in cuproptosis, were proven to be associated with non-small cell lung cancer prognosis and metastasis. Immunohistochemistry showed that their expression significantly predicted metastasis but failed to predict prognosis in non-small cell lung cancer patients. The transwell migration assay further increased the cellular reliability of our findings.
Conclusion
The cuproptosis-related genes prognostic model effectively predicted the prognosis of non-small cell lung cancer. DLAT and DLST may serve as predictive markers for metastasis in non-small cell lung cancer.
Determination of DTaP vaccine potency by multiplex immunogenicity testing using electrochemiluminescence
Authors: Bekeredjian-Ding Isabelle , Friedrichs Bärbel , Rehg Simone , Hanschmann Kay , Öppling Volker 
Published: January 2024

Abstract

Potency testing of diphtheria and tetanus vaccines traditionally relied on in vivo protection models involving challenge of laboratory animals with toxins while lot release of many other vaccine products is based on serological assays. Here we describe the results of simultaneous serological potency determination of diphtheria (D), tetanus (T) and acellular pertussis (aP) antigens obtained following immunization of guinea pigs with multicomponent pediatric and booster vaccines from different manufacturers. The 4th World Health Organization (WHO) International Standard (IS) for diphtheria toxoid (No. 07/216) and the 4th WHO IS for tetanus toxoid (No. 08/218) were used as reference preparations. For aP, a pediatric vaccine batch containing the antigens pertussis toxoid, filamentous hemagglutinin, pertactin and fimbriae proteins type 2/3 was established as internal control. Quantification of IgG against D, T and aP antigens in guinea pig sera was performed using a hexaplex electrochemi-luminescence immunoassay. We further provide proof-of-concept using experimental vaccine samples lacking or containing reduced amounts of diphtheria toxoid in the presence of full amounts of tetanus and pertussis antigens and alum adjuvant. Importantly, the assay confirmed dose-response relationships for all antigens tested and was able to detect subpotent batches. The results confirmed the suitability of the protocol for combined serology batch release testing of DTaP combination vaccines. This report summarizes the data and the protocol used for validation prior to implementation of this method in routine batch release testing of DTaP vaccines, which led to replacement of in vivo challenge experiments in our laboratory following the 3R (replace, reduce, refine) principle.
Construction and verification of a prostate cancer risk prediction model based on traditional screening methods
Authors: Ji Wen-Tong , Wang Yong-Kun , Wang Yao 
Published: January 2024

Abstract
Background
Timely and accurate diagnosis of prostate cancer (PCa) is of paramount importance in guiding treatment and reducing the suffering and death of patients. This study aimed to construct a risk prediction model for PCa based on prostate-specific antigen (PSA) levels, digital rectal examination (DRE), and transrectal ultrasonography (TRUS) to develop a screening tool with better clinical performance.
Methods
We retrospectively analysed 1593 patients who underwent transrectal ultrasound-guided biopsy (TRUSB) between June 2000 and February 2023. Patients were randomly divided into a training set of 1115 cases (70%) and a validation set of 478 patients (30%). A PCa risk prediction model was established using the R software. The performance of the model was examined based on calibration curves, receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and clinical impact curves (CIC).
Results
Serum PSA levels, DRE results, prostatic border, shape, hypoechoic area, and seminal vesicle condition were associated with pathological outcomes. The areas under the (ROC) curves of the training and verification sets were 0.885 and 0.879, respectively. The optimal cut-off value was 0.477. The calibration curves indicated good calibration, and the DCA and CIC results demonstrated good clinical practicality. Subsequently, we developed an online calculator (https://jiwentong0.shinyapps.io/dynnomapp/) with six variables to screen high-risk patients.
Conclusions
This study incorporated the results of three traditional screening methods to establish a highly accurate model for predicting PCa before biopsy. With this model, we aim to provide a non-invasive and cost-effective tool for PCa screening.