bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dielectric Design of High Dielectric Constant Poly(Urea‐Urethane) Elastomer for Low‐Voltage High‐Mobility Intrinsically Stretchable All‐Solution‐Processed Organic Transistors
Authors: Zhang Mingxin , Sun Jing , Zhao Guodong , Tong Yanhong , Wang Xue , Yu Hongyan , Xue Peng , Zhao Xiaoli , Tang Qingxin , Liu Yichun 
Published: February 2024

AbstractStretchable organic transistors for skin‐like biomedical applications require low‐voltage operation to accommodate limited power supply and safe concerns. However, most of the currently reported stretchable organic transistors operate at relatively high voltages. Decreasing their operational voltage while keeping the high mobility still remains a key challenge. Here, the study presents a new dielectric design to achieve high‐dielectric constant poly(urea‐urethane) (PUU) elastomer, by incorporating a flexible small‐molecular diamine crosslinking agent 4‐aminophenyl disulfide (APDS) into the main chain of (poly (propylene glycol), tolylene 2,4‐diiso‐cyanate terminated) (PPG‐TDI). Compared with commercial elastomers, the PUU elastomer as dielectric of the stretchable organic transistors shows the outstanding advantages including lower surface roughness (0.33 nm), higher adhesion (45.18 nN), higher dielectric constant (13.5), as well as higher stretchability (896%). The PUU dielectric enables the intrinsically stretchable, all‐solution‐processed organic transistor to operate at a low operational voltage down to −10 V, while preserving a substantial mobility of 1.39 cm2 V−1 s−1. Impressively, the transistor also demonstrates excellent electrical stability under repeated switching of 10 000 cycles, and remarkable mechanical robustness when stretched up to 100%. The work opens up a new molecular engineering strategy to successfully realize low‐voltage high‐mobility stretchable all‐solution‐processed organic transistors.
Retention modeling of therapeutic peptides in sub‐/supercritical fluid chromatography
Authors: Neumann Jonas , Schmidtsdorff Sebastian , Schmidt Alexander H. , Parr Maria K. 
Published: February 2024

AbstractChromatographic modeling software packages are valuable tools during method optimization steps. These are well established for reversed‐phase applications utilizing retention time (RT) prediction to optimize separations and receive robust methods, which is of high interest for the analysis of pharmaceuticals. In contrast to liquid chromatography, the knowledge of RT prediction in supercritical fluid chromatography is limited to a manageable number of studies.This study uses the software DryLab to predict the RTs of the peptides bacitracin (Bac), colistin, tyrothricin (Tyro), and insulin analogs. Gradient time, column temperature, and the ternary composition (terC) of carbon dioxide, methanol (MeOH), and acetonitrile (ACN) in the gradient elution are varied in a feasibility approach using a neutral (Viridis BEH) and an amino‐derivatized aromatic (Torus 2‐PIC) stationary phase. In the second part, chromatographic optimization is performed in silico through gradient adjustments to optimize the separation of the fingerprint of Bac. The final gradient method utilizes a Viridis BEH column (100 × 3.0 mm, 1.7 μm), carbon dioxide, and a modifier consisting of ACN/MeOH/water/methanesulfonic acid (60:40:2:0.1, v:v:v:v). In addition, changes in the retention order of Tyro compounds with the proportion of the terC in combination with a Torus Diol column are investigated.
Humanizing History: Using Historical Fiction Texts to Develop Disciplinary and Racial Literacies
Authors: La Croix Leslie , Vesely Colleen K. , Steen Bweikia F. 
Published: February 2024

AbstractHistorical fiction is a powerful genre for inviting children into meaningful conversations centered on the lived experiences of others. Historical inquiry immerses readers in interdisciplinary research experiences and complements language arts Common Core State Standards that call for a balance of fiction and non‐fiction text. Antiracist lenses enhance inquiry conversations and help students articulate nuanced understandings of the fictionalized historical events while developing disciplinary and racial literacy knowledge necessary for humanizing history. This article highlights how we, as teacher educators, use historical fiction to engage teacher candidates in inquiry‐based social studies lessons to develop their disciplinary and racial literacy skills and practices. Then, we offer an example of how to integrate the C3 inquiry approach using Finding Langston (Cline‐Ransome, 2018), a historical fiction text set during the Great Migration, to engage elementary‐aged readers in explorations of history, sparking children’s agency and engagement in their own learning.
Cadaveric comparison of two techniques for intraoperative placement of tibial plateau levelling osteotomies in dogs
Authors: Jaworski Janusz , Meek Matt , Malortie Selena , Dudley Robert 
Published: February 2024

AbstractBackgroundBoth tibial tuberosity fractures and deviation from the planned postoperative tibial plateau angle have been associated with poor centring of tibial plateau levelling osteotomies (TPLOs). The aim of this cadaveric study was to compare two techniques for centring the osteotomy and preserving the tibial tuberosity width (TTW).MethodsStifle radiographs were obtained from 20 limbs of 10 dogs. TPLO was planned on each stifle, and a two‐wire technique (TWT) and a technique using the medial collateral ligament (MCL) as an intraoperative landmark were planned. The techniques were executed and marked with radiopaque pins. Further radiographs were obtained and analysed.ResultsOn average, TWT resulted in a 20.4% increase in TTW and medial collateral ligament technique (MCLT) resulted in a 13.4% decrease. Expressed as a percentage of the radial saw size, the average error in the centring of the osteotomy arising from the TWT was 13.4% and that from the MCLT was 14.2%.LimitationsThis study had a small sample size and involved a single surgeon.ConclusionNeither technique reliably identified the desired centre of the osteotomy, and both had a similar magnitude of error. MCLT resulted in reduced TTW, while TWT resulted in increased TTW. A reduced TTW has been associated with an increased risk of tibial tuberosity fracture, so MCLT is not recommended for clinical use.
The achievement gap thesis reconsidered: artificial intelligence, automation, and meaningful work
Authors: Scripter Lucas 
Published: February 2024

Abstract
John Danaher and Sven Nyholm have argued that automation, especially of the sort powered by artificial intelligence, poses a threat to meaningful work by diminishing the chances for meaning-conferring workplace achievement, what they call “achievement gaps”. In this paper, I argue that Danaher and Nyholm’s achievement gap thesis suffers from an ambiguity. The weak version of the thesis holds that automation may result in the appearance of achievement gaps, whereas the strong version holds that automation may result on balance loss in possibilities for workplace achievements, i.e., in the appearance of an overall gappier work landscape. Against the strong version of the achievement gap thesis, I characterize situations where automation may result in boons to meaning-conferring workplace achievements: the appearance of what I call achievement spread and achievement swaps. Nevertheless, Danaher and Nyholm are right to worry about some uses of automation whereby human workers become subservient to AI. But these situations are better framed, I argue, as autonomy gaps rather than achievement gaps.
Dynamics of Antimicrobial Resistance Carriage in Koalas (Phascolarctos Cinereus) and Pteropid Bats (Pteropus Poliocephalus) Before, During and After Wildfires
Authors: McDougall Fiona K. , Speight Natasha , Funnell Oliver , Boardman Wayne S. J. , Power Michelle L. 
Published: February 2024

AbstractIn the 2019–2020 summer, wildfires decimated the Australian bush environment and impacted wildlife species, including koalas (Phascolarctos cinereus) and grey headed flying fox pups (Pteropid bats, Pteropus poliocephalus). Consequently, hundreds of koalas and thousands of bat pups entered wildlife hospitals with fire-related injuries/illness, where some individuals received antimicrobial therapy. This study investigated the dynamics of antimicrobial resistance (AMR) in pre-fire, fire-affected and post-fire koalas and Pteropid bat pups. PCR and DNA sequencing were used to screen DNA samples extracted from faeces (koalas and bats) and cloacal swabs (koalas) for class 1 integrons, a genetic determinant of AMR, and to identify integron-associated antibiotic resistance genes. Class 1 integrons were detected in 25.5% of koalas (68 of 267) and 59.4% of bats (92 of 155). Integrons contained genes conferring resistance to aminoglycosides, trimethoprim and beta-lactams. Samples were also screened for blaTEM (beta-lactam) resistance genes, which were detected in 2.6% of koalas (7 of 267) and 25.2% of bats (39 of 155). Integron occurrence was significantly higher in fire-affected koalas in-care compared to wild pre-fire koalas (P < 0.0001). Integron and blaTEM occurrence were not significantly different in fire-affected bats compared to pre-fire bats (P > 0.05), however, their occurrence was significantly higher in fire-affected bats in-care compared to wild fire-affected bats (P < 0.0001 and P = 0.0488 respectively). The observed shifts of AMR dynamics in wildfire-impacted species flags the need for judicious antibiotic use when treating fire-affected wildlife to minimise unwanted selective pressure and negative treatment outcomes associated with carriage of resistance genes and antibiotic resistant bacteria.
Endoscopic and surgical treatment of necrotizing pancreatitis—a comparison of short- and long-term outcome
Authors: Timmermann Lea , Schönauer Svenja , Hillebrandt Karl Herbert , Felsenstein Matthäus , Pratschke Johann , Malinka Thomas , Jürgensen Christian 
Published: February 2024

Abstract
Background
Acute necrotizing pancreatitis is still related to high morbidity and mortality rates. Minimal-invasive treatment options, such as endoscopic necrosectomy, may decrease peri-interventional morbidity and mortality. This study aims to compare the initial operative with endoscopic treatment on long-term parameters, such as endocrine and exocrine functionality, as well as mortality and recurrence rates.

Methods
We included 114 patients, of whom 69 were treated with initial endoscopy and 45 by initial surgery. Both groups were further assessed for peri-interventional and long-term parameters.

Results
In the post-interventional phase, patients in the group of initial surgical treatment (IST) showed significantly higher rates of renal insufficiency (p < 0.001) and dependency on invasive ventilation (p < 0.001). The in-house mortality was higher in the surgical group, with 22% vs. 10.1% in the group of patients following initial endoscopic treatment (IET; p = 0.077). In long-term follow-up, the overall mortality was 45% for IST and 31.3% for IET (p = 0.156). The overall in-hospital stay and intensive care unit (ICU) stay were significantly shorter after IET (p < 0.001). In long-term follow-up, the prevalence of endocrine insufficiency was 50% after IST and 61.7% after IET (p = 0.281). 57.1% of the patients following IST and 16.4% of the patients following IET had persistent exocrine insufficiency at that point (p =  < 0.001). 8.9% of the IET and 27.6% of the IST patients showed recurrence of acute pancreatitis (p = 0.023) in the long-term phase.

Conclusion
In our cohort, an endoscopic step-up approach led to a reduced in-hospital stay and peri-interventional morbidity. The endocrine function appeared comparable in both groups, whereas the exocrine insufficiency seemed to recover in the endoscopic group in the long-term phase. These findings advocate for a preference for endoscopic treatment of acute necrotizing pancreatitis whenever feasible.
Refeeding syndrome and psychopharmacological interventions in children and adolescents with Anorexia Nervosa: a focus on olanzapine-related modifications of electrolyte balance
Authors: Pruccoli Jacopo , Barbieri Elena , Visconti Caterina , Pranzetti Beatrice , Pettenuzzo Ilaria , Moscano Filomena , Malaspina Elisabetta , Marino Marastella , Valeriani Beatrice , Parmeggiani Antonia 
Published: February 2024

AbstractThis study aims to investigate the potential correlation between the use of olanzapine, a psychopharmacological intervention commonly prescribed in Anorexia Nervosa treatment, and the occurrence of Refeeding Syndrome. Despite the acknowledged nutritional and biochemical impacts of olanzapine, the literature lacks information regarding its specific association with Refeeding Syndrome onset in individuals with Anorexia Nervosa. This is a naturalistic, retrospective, observational study, reporting the occurrence of Refeeding Syndrome in children and adolescents with Anorexia Nervosa, treated or untreated with olanzapine. Dosages and serum levels of olanzapine were assessed for potential associations with the occurrence of Refeeding Syndrome and specific variations in Refeeding Syndrome–related electrolytes. Overall, 113 patients were enrolled, including 46 (41%) who developed a Refeeding Syndrome. Mild (87%), moderate (6.5%), and severe (6.5%) Refeeding Syndrome was described, at a current average intake of 1378 ± 289 kcal/day (39 ± 7.7 kcal/kg/die), frequently associated with nasogastric tube (39%) or parenteral (2.2%) nutrition. Individuals receiving olanzapine experienced a more positive phosphorus balance than those who did not (F(1,110) = 4.835, p = 0.030), but no difference in the occurrence of Refeeding Syndrome was documented. The mean prescribed doses and serum concentrations of olanzapine were comparable between Refeeding Syndrome and no-Refeeding Syndrome patients. Conclusion: The present paper describes the occurrence of Refeeding Syndrome and its association with olanzapine prescriptions in children and adolescents with Anorexia Nervosa. Olanzapine was associated with a more positive phosphorus balance, but not with a different occurrence of Refeeding Syndrome. Further, longitudinal studies are required.

What is Known:• Refeeding Syndrome (RS) is a critical complication during refeeding in malnourished patients, marked by electrolyte (phosphorus, magnesium, potassium) imbalances.• Olanzapine, an atypical antipsychotic with nutritional and biochemical impacts, is used in Anorexia Nervosa (AN) treatment, however data concerning its association with RS are lacking.

What is New:• The study observed RS in 46/113 (41%) young patients with AN.• Olanzapine-treated individuals showed a higher improvement in serum phosphate levels than untreated ones, although no impact on the occurrence of Refeeding Syndrome was observed.
Critical Examination of the Representativeness of Austenite Grain Growth Studies Performed In Situ Using HT-LSCM and Application to Determine Growth-inhibiting Mechanisms
Authors: Kern Maximilian , Bernhard Michael , Presoly Peter , Brandl Dominik , Bernhard Christian 
Published: February 2024

AbstractThis contribution critically addresses the potential of HT-LSCM experiments for in situ observations of austenite grain growth (AGG). By quantifying AGG for various alloys, the impact of impurity induced solute drag effects (SDE) and second phase precipitation Zener pinning forces (PZ) on AGG can be estimated. Also the grain boundary mobility (GBM) can be determined. The measured arithmetic mean of the time-resolved grain size distributions as a function of temperature and chemical composition is the most important value for quantification. The obtained data is then used to contribute to mathematical models of classical grain growth theory and to allow conclusions on parametrization of SDE and PZ. In this contribution, grain size measurements at the sample surface (in situ and ex situ) are compared with ex situ bulk measurements and experiments on grain growth in the single-phase austenite region (γ-Fe) under isothermal annealing conditions at different temperatures are presented. Grain growth results include high-purity Fe (Fe > 99.98%), binary Fe‑P, Fe‑C, and quaternary Fe-C-Nb‑N systems. For the alloys investigated, it is assumed that grain growth in high-purity Fe occurs without the influence of solute drag or precipitation mechanisms. In Fe‑P, it is shown that grain growth is inhibited by the segregation of impurity atoms at the grain boundaries (GB), which allows conclusions to be drawn about the influence of SDE. In the case of Fe-C-Nb‑N systems, the influence of Nb(C,N) precipitation on grain growth due to Zener pinning forces is presented.
Physical activity and psychopathology: are long-term developmental trajectories of physical activity in children and adolescents associated with trajectories of general mental health problems and of attention-deficit hyperactivity (ADHD) symptoms?
Authors: Ganjeh Parisa , Hagmayer York , Meyer Thomas , Kuhnert Ronny , Ravens-Sieberer Ulrike , von Steinbuechel Nicole , Rothenberger Aribert , Becker Andreas 
Published: February 2024

AbstractA medium-to-high level of physical activity (PA) may have at least a short-term positive effect on psychopathology in children and adolescents. Hence, the objective of this study was to investigate the long-term effects of PA in non-adult age groups on their general mental health problems and/or ADHD symptoms, using trajectories of concurrent development over a period of 10 years. This study employed data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) collected at three time points (baseline, Wave 1, Wave 2, over 10 years) from 17,640 children and adolescents. Using parent-reported data from the Strengths and Difficulties Questionnaire (SDQ), different developmental trajectories of general mental health problems (SDQ-total) and ADHD symptoms (SDQ-H/I) were identified with latent class mixed models (LCMM) statistics. This was also applied to parent- and self-reported data of three levels of PA. The latter was assessed according to WHO recommendations. The joint probability of class membership for SDQ-total as well as ADHD symptoms with PA was calculated to generate the concurrent developmental trajectories between variables. Results showed a 4-class trajectory model for both SDQ-total and ADHD symptoms among boys and girls. The majority of children and adolescents showed “low general difficulties” and “low ADHD symptoms” over the period of 10 years. Three distinct trajectories in boys and four distinct trajectories in girls were found for PA. Most of the participants showed an “increasing–decreasing activity” trajectory. No statistically significant correlations were found between the different SDQ-total or ADHD symptom trajectories and the trajectories of PA in the two genders. Taken together, our findings did not indicate any significant relationship between waxing and waning PA course over 10 years and various classes of mental health problems for children and adolescents. In contrast to our cross-sectional findings, no steady long-term medium/high-level of PA was present, which could (at least partly) explain the non-significant findings.
Recycling water treatment sludge into a novel eco-friendly core–shell lightweight aggregate and its application
Authors: Mahanna Hani , Alaa Ahmed , Salah Heba , Tahwia Ahmed M. 
Published: February 2024

AbstractDisposal of water treatment sludge (WTS) has become an important issue of global environmental concern due to problems and costs. This study explored the feasibility of cold-bond methodology to produce an eco-friendly core–shell lightweight aggregate (LWA) from WTS, expanded perlite (EP), and cement. The effect of cement and WTS content on the properties of the LWA was studied. The findings revealed that the crushing strength, loose bulk density, 24-h water absorption, and 28-d water absorption of produced LWA ranged from 0.45 to 3.1 MPa, 1.05 to 1.25 g/cm3, 12.4 to 22%, and 22 to 27%, respectively. In addition, increasing the WTS content in the shell has a positive impact on the pH of the produced LWA. Furthermore, the SEM microstructure graphs revealed the efficient interference in the LWA particles between the cement–WTS composite and the perlite. The results also prove the possibility of using the produced LWA to produce structural lightweight concrete, with compressive strength, splitting tensile strength, and dry density of 24 MPa, 2.98 MPa, and 1840 kg/m3, respectively, with a consistent thermal conductivity of 0.72 W/m K and good acoustic insulation.
Graphical abstract
Prognostic impact of peripheral blood WT1 mRNA dynamics in patients with acute myeloid leukemia treated with venetoclax combination therapy
Authors: Sato Honami , Kobayashi Takahiro , Kameoka Yoshihiro , Teshima Kazuaki , Watanabe Atsushi , Yamada Masahiro , Yamashita Takaya , Noguchi Shinsuke , Michisita Yoshihiro , Fujishima Naohito , Kuroki Jun , Takahashi Naoto 
Published: February 2024

Abstract
Background
Wilms' tumor gene 1 (WT1) mRNA quantification is a useful marker of measurable residual disease in acute myeloid leukemia (AML). However, whether monitoring the WT1 mRNA levels may predict the outcome of venetoclax (VEN) combination therapy in AML is not reported. This study aims to elucidate whether WT1 mRNA dynamics could predict long-term prognosis.

Methods
33 patients with untreated or relapsed/refractory AML evaluated for peripheral blood WT1 dynamics in VEN combination therapy were analyzed.

Results
The median age was 73 years (range 39–87). Azacitidine was combined with VEN in 91% of patients. Overall, the median overall survival (OS) was 334 days (95% CI 210–482), and the complete remission (CR) plus CR with incomplete hematologic recovery rate was 59%. A 1-log reduction of WT1 mRNA values by the end of cycle 2 of treatment was associated with significantly better OS and event-free survival (EFS) (median OS 482 days vs. 237 days, p = 0.049; median EFS 270 days vs. 125 days, p = 0.02). The negativity of post-treatment WT1 mRNA value during the treatment was associated with significantly better OS and EFS (median OS 482 days vs. 256 days, p = 0.02; median EFS not reached vs. 150 days, p = 0.005). Multivariate analysis confirmed the significance of these two parameters as strong EFS predictors (HR 0.26, p = 0.024 and HR 0.15, p = 0.013, respectively). The increase in WT1 mRNA values was correlated with relapse.

Conclusion
This study demonstrates that WT1 mRNA dynamics can be a useful marker for assessing long-term prognosis of VEN combination therapy for AML.