bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Design of Single‐atom Modified Ti‐MOFs for Photocatalytic CO2 Reduction to C1 Chemicals
Authors: Wang Shuang , Nie Xiaowa , Lin Jianbin , Ding Fanshu , Song Chunshan , Guo Xinwen 
Published: December 2023

AbstractIn this work, density functional theory (DFT) calculations were conducted to investigate a series of transition metals (Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Ru, Rh, Pd, Ag, Hf, Ta, Os, Ir, and Pt) as single‐atom components introduced into Ti‐BPDC (BPDC=2,2′‐bipyridine‐5,5′‐dicarboxylic acid) as catalysts (M/Ti‐BPDC) for the photocatalytic reduction of CO2. The results show that Fe/Ti‐BPDC is the most active candidate for CO2 reduction to HCOOH due to its small limiting potential (−0.40 V). Ag, Cr, Mn, Ru, Zr, Nb, Rh, and Cu modified Ti‐BPDC are also active to HCOOH since their limiting potentials are moderate although the reaction mechanisms are different across these materials. Most of the studied catalysts show poor activity and selectivity to CO product because the stability of *COOH/*OCOH intermediates is significantly weaker than *OCHO/*HCOO species. The moderate binding strength of *CO on Pd/Ti‐BPDC is responsible for its superior catalytic activity toward CH3OH generation. Electronic structural analysis was performed to uncover the origin of the activity trend for CO2 reduction to different products on M/Ti‐BPDC. The calculation results indicate that the activity and selectivity of CO2 photoreduction can be effectively tuned by designing single‐atom metal‐based MOF catalysts.
Does intraspecific competition cause oxidative stress? Influence of biotic and abiotic factors on antioxidant system of an invasive round goby
Authors: Błońska Dagmara , Tarkan Ali Serhan , Janic Bartosz , Tszydel Mariusz , Bukowska Bożena 
Published: December 2023

AbstractChanges in oxidative status represent organismal response to stressful external stimuli. While there is substantial knowledge on the influence of abiotic factors on the antioxidant system of different organisms, the impact of biotic factors remains largely unexplored. The aim of the present study was to evaluate the effect of acute competitive interactions on oxidative stress. Territory‐resident and intruder round goby Neogobius melanostomus individuals were experimentally subjected to competition for limited shelter resource in three treatments (lasting 1, 6 and 12 h), and oxidative stress parameters (total antioxidant capacity, catalase activity, reduced glutathione, lipid peroxidation), as well as behaviour (time spent in the shelter, guarding the shelter and aggression) were measured. All tested biochemical parameters reached higher values in the liver than in the muscle tissue. Fish behaviour and antioxidant defence did not show any potential relationships reflecting changes in antioxidant status and aggression. Particularly, there was no difference between resident and intruder fish in oxidative stress parameters. We compared our results to the outcome of our previous studies (similar experimental protocol and species) but with acute heat shock as a stressor instead of competition. The higher temperature was found to be a stronger stressor than the competition, most pronounced in total antioxidant capacity and oxidative damage.
Angiographic classification of total occlusion and its implication on balloon pulmonary angioplasty
Authors: Yang Tao , Li Xin , Luo Qin , Zhao Qing , Zeng Qixian , Zhang Yi , Duan Anqi , Huang Zhihua , Hu Meixi , Zhang Sicheng , Gao Luyang , Xiong Changming , Zhao Zhihui , Liu Zhihong 
Published: December 2023

AbstractAimsDespite refinements in balloon pulmonary angioplasty (BPA), total occlusion remains a challenge in chronic thromboembolic pulmonary hypertension (CTEPH). Owing to their low success and high complication rates, most interventional cardiologists are reluctant to address total occlusion, and there is a paucity of literature on BPA performance in total occlusion. We aimed to classify total occlusion according to morphology and present an illustrative approach for devising a tailored treatment strategy for each distinct type of total occlusion.Methods and resultsAll patients diagnosed with CTEPH who underwent BPA between May 2018 and May 2022 at Fuwai Hospital in Beijing, China, were included retrospectively. A total of 204 patients with CTEPH who underwent BPA were included in this study. Among these, 38 occluded lesions were addressed in 33 patients. Based on the morphology, we categorized the lesions into three groups: pointed‐head, round‐head, and orifice occlusions. Pointed‐head occlusion could be successfully addressed using soft‐tip wire, round‐head occlusion warranted hard‐tip wire and stronger backup, and orifice occlusion warranted the strongest backup force. The success rates for each group were as follows: pointed‐head (95.45%), round‐head (46.15%), and orifice occlusion (33.33%), with orifice occlusion having the highest complication rate (50%). The classification of occlusion was associated with BPA success (round‐head occlusion vs. pointed‐head occlusion, OR 24.500, 95% CI 2.498–240.318, P = 0.006; orifice occlusion vs. pointed‐head occlusion, OR 42.000, 95% CI 3.034–581.434, P = 0.005).ConclusionsOcclusion morphology has a significant impact on BPA success and complication rates. A treatment strategy tailored to each specific occlusive lesion, as outlined in the present study, has the potential to serve as a valuable guide for clinical practitioners.
Lewis Base‐Boryl Radicals Promoted Selective Mono‐ and Di‐ Hydrodechlorination of Trichloroacetamides and Acetates
Authors: Bo Ming‐Cheng , Phang Yee Lin , Zhao Qiang , Zhang Feng‐Lian , Wang Yi‐Feng 
Published: December 2023

AbstractMono and dichloro‐substituted organic molecules are shown to possess significant roles in various fields, especially in medicinal chemistry. One approach to synthesizing these compounds involves the selective dechlorination of easily prepared trichloromethyl compounds. Nevertheless, developing a practical approach that allows selective mono‐ and dihydrodechlorination is a challenging task. Herein, we introduced a method for selective mono‐ and dihydrodechlorination of trichloroacetamides and acetates which was promoted by two different Lewis base‐boryl radicals. Accordingly, 4‐dimethylaminopyridine (DMAP)‐borane enabled mono‐substitution of chlorine atom by hydrogen while dihydro‐substitution of chlorine atoms was promoted by N‐heterocyclic carbene (NHC)‐boryl radical. Using deuterated Lewis base‐borane as deuterium atom source, mono‐ and dideuterodechlorination were also successfully took place. This protocol features broad substrate scope and operates under mild reaction conditions.
Development of a nomogram for predicting pharyngocutaneous fistula based on skeletal muscle mass and systemic inflammation indices
Authors: Wu Ce , Yan Xudong , Xie Feng , Lai Xiaolong , Wang Lin , Jiang Yan 
Published: December 2023

AbstractBackgroundLaryngeal and hypopharyngeal cancers often require surgical treatment, which can lead to the development of pharyngocutaneous fistula (PCF). Our research aimed to assess the predictive value of skeletal muscle mass (SMM) and systemic inflammation indices for PCF and construct a clinically effective nomogram.MethodsA nested case–control study of 244 patients matched from 1171 patients with laryngeal or hypopharyngeal cancer was conducted. SMM was measured at the third cervical level based on CT scans. A PCF nomogram was developed based on the univariate and multivariate analyses.ResultsGlucose, white blood cell count, platelet‐to‐lymphocyte ratio, and skeletal muscle index were independent risk factors for PCF. The area under the curve for the PCF nomogram was 0.841 (95% CI 0.786–0.897). The calibration and decision curves indicated that the nomogram was well‐calibrated with good clinical utility.ConclusionsThe nomogram we constructed may help clinicians predict PCF risk early in the postoperative period, pending external validation.
Incorporating climate change model projections into ecological risk assessments to help inform risk management and adaptation strategies: Synthesis of a SETAC Pellston Workshop®
Authors: Stahl Ralph G. , Boxall Alistair B.A. , Brix Kevin V. , Landis Wayne G. , Stauber Jenny L. , Moe S. Jannicke 
Published: December 2023

Abstract
The impacts of global climate change are not yet well integrated with the estimates of the impacts of chemicals on the environment. This is evidenced by the lack of consideration in national or international reports that evaluate the impacts of climate change and chemicals on ecosystems and the relatively few peer-reviewed publications that have focused on this interaction. In response, a 2011 Pellston Workshop® was held on this issue and resulted in seven publications in Environmental Toxicology and Chemistry. Yet, these publications did not move the field toward climate change and chemicals as important factors together in research or policy-making. Here, we summarize the outcomes of a second Pellston Workshop® on this topic held in 2022 that included climate scientists, environmental toxicologists, chemists, and ecological risk assessors from 14 countries and various sectors. Participants were charged with assessing where climate models can be applied to evaluating potential exposure and ecological effects at geographical and temporal scales suitable for ecological risk assessment, and thereby be incorporated into adaptive risk management strategies. We highlight results from the workshop's five publications included in the special series “Incorporating Global Climate Change into Ecological Risk Assessments: Strategies, Methods and Examples.” We end this summary with the overall conclusions and recommendations from participants. Integr Environ Assess Manag 2024;20:359–366. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
How to enhance the applicability of a risk prediction model for term small‐for‐gestational‐age neonates in clinical settings?
Authors: Kong Shao‐Min , Gao Chang , Yu Ang , Lin Shan‐Shan , Wei Dong‐Mei , Wang Cheng‐Rui , Lu Jin‐Hua , Zeng Ding‐Yuan , Zhang Jun , He Jian‐Rong , Qiu Xiu 
Published: December 2023

AbstractObjectiveTo construct a simple term small‐for‐gestational‐age (SGA) neonate prediction model that is clinically practical.MethodsThis analysis was based on the Born in Guangzhou Cohort Study (BIGCS). Mothers who had a singleton pregnancy, delivered a term neonate, and had an ultrasonography within 30 + 0 to 32 + 6 weeks of gestation were included. Term SGA was defined with customized population percentiles. Prediction models were constructed with backward selection logistic regression in a four‐step approach, where model 1 contained fetal biometrics only, models 2 and 3 included maternal features and a time factor (weeks between ultrasonography and delivery), respectively; and model 4 contained all features mentioned. The prediction performance of individual models was evaluated based on area under the curve (AUC) and a calibration test was performed.ResultsThe prevalence of SGA in the study population of 21 346 women was 11.5%. With a complete‐case analysis approach, data of 19 954 women were used for model construction and validation. The AUC of the four models were 0.781, 0.793, 0.823, and 0.834, respectively, and all were well‐calibrated. Model 3 consisted of fetal biometrics and corrected for time to delivery was chosen as the final model to build risk prediction graphs for clinical use.ConclusionA prediction model derived from fetal biometrics in early third trimester is satisfactory to predict SGA.
Gene expression of cardiovascular risk markers in mononuclear cells of pregnant woman in relation to plasma leptin and homocysteine levels: A cross sectional study
Authors: Abundis Eduardo Martínez , Hernandez‐Landero Fernanda , Escobar‐Calderon Grecia , Gomez‐Crisostomo Nancy , Contreras‐Paredes Adriana , de la Cruz‐Hernandez Erick 
Published: December 2023

AbstractObjectiveTo investigate the relationship between anthropometric, biochemical, and hematologic parameters and serum leptin and homocysteine (Hcy) levels. Also, to determine the effect of leptin and Hcy on expression of genes associated with cardiovascular disease susceptibility (APOA1, LRP1, COX‐1, and COX‐2) in mononuclear cells of healthy pregnant women.MethodsBetween August 2018 and January 2020, a cross‐sectional study was conducted on 161 healthy pregnant women in Tabasco, southeastern Mexico. The study population was classified by trimester, according to gestational pregnancy. Anthropometric, biochemical (leptin and homocysteine), and hematologic data were obtained under fasting conditions. APOA1, LRP1, COX‐1, and COX‐2 expression in mononuclear cells was evaluated using RT‐qPCR.ResultsRed cell indices (hemoglobin, hematocrit, and erythrocytes) were negatively and positively correlated with leptin and Hcy levels, respectively, in the first‐ and second‐trimester groups. Increased leptin levels and low red cell indices were significantly associated with BMI <25.0 in the second‐trimester group; however, no significant differences were observed in Hcy levels. Increased leptin and Hcy levels were significantly associated with high lipid indicators in the first‐ and third‐trimester groups, respectively. High APOA1 and COX‐2 expression was significantly associated with reduced leptin and increased Hcy levels in the second‐ and third‐trimester groups.ConclusionIncreased leptin and Hcy levels during pregnancy, mainly associated with modifications in erythrocytes and lipid indices, may lead to early modification of genes related to lipid metabolism (APOA1) and proinflammatory response (COX‐2) and, thereby, increase cardiovascular disease risk.
Ovarian reserve markers of women with superficial endometriosis
Authors: Lessans Naama , Gilan Adi , Dick Aharon , Bibar Natalie , Saar Tal D. , Porat Shay , Dior Uri P. 
Published: December 2023

AbstractObjectiveEndometriosis affects up to 10% of reproductive age women and is associated with pelvic pain and subfertility. While previous studies have shown an association between deep and ovarian endometriosis to reduced ovarian reserve, there is no data on the effect of superficial endometriosis on ovarian reserve markers. Hence, we aimed to compare ovarian reserve markers of women with superficial endometriosis to that of women without endometriosis.MethodsThis was a case control study in a tertiary medical center. The study group included women aged 18–40 with surgically and histopathology‐proven superficial endometriosis with no deep lesions or ovarian involvement. The control group included women with no known or suspected endometriosis and was matched to the study group by age, BMI and parity. We excluded women with other known risk factors for ovarian failure and with other gynecological disorders. Participants completed a questionnaire with demographic, medical and gynecological data. Each patient underwent anti‐Mullerian hormone (AMH) testing and an ultrasound to assess their antral follicular count (AFC). AMH and AFC were then compared between groups.ResultsA total of 124 women participated in the study. Of these, 50% (n = 62) had surgically proven superficial endometriosis and 50% (n = 62) were without known or suspected endometriosis. Mean AMH levels of women with and without superficial endometriosis was 3.0 ± 2.8 ng/mL and 2.8 ± 1.9 ng/mL, respectively (P = 0.71). AFC also did not differ between groups (women with superficial endometriosis: 12.0 ± 6.6; women without endometriosis: 10.2 ± 5.0, P = 0.15).ConclusionsIn our cohort, superficial endometriosis was not associated with diminished ovarian reserve. While further studies are needed, to date, it does not appear to be justified to assess ovarian reserve for patients with superficial endometriosis.
Bifunctional tissue‐engineered composite construct for bone regeneration: The role of copper and fibrin
Authors: Bozorgi Azam , Khazaei Mozafar , Bozorgi Maryam , Sabouri Leila , Soleimani Mansooreh , Jamalpoor Zahra 
Published: December 2023

AbstractBifunctional tissue engineering constructs promoting osteogenesis and angiogenesis are essential for bone regeneration. Metal ion‐incorporated scaffolds and fibrin encapsulation attract much attention due to low cost, nontoxicity, and tunable control over ion and growth factor release. Herein, we investigated the effect of Cu.nHA/Cs/Gel scaffold and fibrin encapsulation on osteogenic and angiogenic differentiation of Wharton's jelly mesenchymal stem cells (WJMSCs) in vitro and in vivo. Cu‐laden scaffolds were synthesized using salt leaching/freeze drying and were characterized using standard techniques. WJMSCs were isolated from the human umbilical cord and characterized. WJMSCs with or without encapsulating in fibrin were seeded onto scaffolds, followed by differentiating into the osteogenic lineage for 7 and 21 days. Osteogenic and angiogenic differentiation were evaluated using real‐time polymerase chain reaction, western blot, and Alizarin red staining. Then, scaffolds were implanted into critical‐sized calvarial bone defects in rats and histological assessments were performed using hematoxylin/eosin, Masson's trichrome, and CD31 immunohistochemical staining at 4 and 12 weeks. The scaffolds had good physicochemical and biological characteristics suitable for cell attachment and growth. Cu and fibrin increased the expression of ALP, RUNX2, OCN, COLI, VEGF, and HIF1α in differentiated WJMSCs. Implanted scaffolds were also biocompatible and were integrated well with the host tissue. Increased collagen condensation, mineralization, and blood vessel formation were observed in Cu‐laden scaffolds. The fibrin‐encapsulated groups showed the highest collagen and cell densities, immune cell infiltration, and bone trabeculae. CD31‐positive cell population increased with fibrin encapsulation and seeding onto Cu‐laden scaffolds. Adding Cu to scaffolds and encapsulating cells in fibrin are promising methods that guide osteogenesis and angiogenesis cellular signaling, leading to better bone regeneration.
Effect of insulin insufficiency on ultrastructure and function in skeletal muscle
Authors: Kopecky Chantal , Haug Michael , Reischl Barbara , Deshpande Nandan , Manandhar Bikash , King Thomas W. , Lee Victoria , Wilkins Marc R. , Morris Margaret , Polly Patsie , Friedrich Oliver , Rye Kerry‐Anne , Cochran Blake J. 
Published: December 2023

AbstractBackgroundDecreased insulin availability and high blood glucose levels, the hallmark features of poorly controlled diabetes, drive disease progression and are associated with decreased skeletal muscle mass. We have shown that mice with β‐cell dysfunction and normal insulin sensitivity have decreased skeletal muscle mass. This project asks how insulin deficiency impacts on the structure and function of the remaining skeletal muscle in these animals.MethodsSkeletal muscle function was determined by measuring exercise capacity and specific muscle strength prior to and after insulin supplementation for 28 days in 12‐week‐old mice with conditional β‐cell deletion of the ATP binding cassette transporters ABCA1 and ABCG1 (β‐DKO mice). Abca1 and Abcg1 floxed (fl/fl) mice were used as controls. RNAseq was used to quantify changes in transcripts in soleus and extensor digitorum longus muscles. Skeletal muscle and mitochondrial morphology were assessed by transmission electron microscopy. Myofibrillar Ca2+ sensitivity and maximum isometric single muscle fibre force were assessed using MyoRobot biomechatronics technology.ResultsRNA transcripts were significantly altered in β‐DKO mice compared with fl/fl controls (32 in extensor digitorum longus and 412 in soleus). Exercise capacity and muscle strength were significantly decreased in β‐DKO mice compared with fl/fl controls (P = 0.012), and a loss of structural integrity was also observed in skeletal muscle from the β‐DKO mice. Supplementation of β‐DKO mice with insulin restored muscle integrity, strength and expression of 13 and 16 of the dysregulated transcripts in and extensor digitorum longus and soleus muscles, respectively.ConclusionsInsulin insufficiency due to β‐cell dysfunction perturbs the structure and function of skeletal muscle. These adverse effects are rectified by insulin supplementation.
Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity
Authors: Shahtout Justin L. , Eshima Hiroaki , Ferrara Patrick J. , Maschek J. Alan , Cox James E. , Drummond Micah J. , Funai Katsuhiko 
Published: December 2023

AbstractBackgroundLipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of the Lands cycle, conjugates a polyunsaturated fatty acyl chain to a lysophospholipid to form a polyunsaturated fatty acid containing phospholipid (PUFA‐PL) molecule, providing substrates for LOOH propagation. Previous studies suggest that inhibition of the Lands cycle is an effective strategy to suppress LOOH. Mice with skeletal muscle‐specific tamoxifen‐inducible knockout of LPCAT3 (LPCAT3‐MKO) were utilized to determine if muscle‐specific attenuation of LOOH may alleviate muscle atrophy and weakness with disuse.MethodsLPCAT3‐MKO and control mice underwent 7 days of sham or hindlimb unloading (HU model) to study muscle mass and force‐generating capacity. LOOH was assessed by quantifying 4‐hydroxynonenal (4‐HNE)‐conjugated peptides. Quantitative PCR and lipid mass spectrometry were used to validate LPCAT3 deletion.ResultsSeven days of HU was sufficient to induce muscle atrophy and weakness concomitant to a ~2‐fold increase in 4‐HNE (P = 0.0069). Deletion of LPCAT3 reversed HU‐induced increase in muscle 4‐HNE (P = 0.0256). No difference was found in body mass, body composition, or caloric intake between genotypes. The soleus (SOL) and plantaris (PLANT) muscles of the LPCAT3‐MKO mice experienced ~15% and ~40% less atrophy than controls, respectively. (P = 0.0011 and P = 0.0265). Type I and IIa SOL myofibers experienced a ~40% decrease in cross sectional area (CSA), which was attenuated to only 15% in the LPCAT3‐MKO mice (P = 0.0170 and P = 0.0411, respectively). Strikingly, SOL muscles were fully protected and extensor digitorum longus (EDL) muscles experienced a ~35% protection from HU‐induced reduction in force‐generating capacity in the LPCAT3‐MKO mice compared with controls (P < 0.0001 for both muscles).ConclusionsOur findings demonstrate that attenuation of skeletal muscle lipid hydroperoxides is sufficient to restore its function, in particular a protection from reduction in muscle specific force. Our findings suggest muscle lipid peroxidation contributes to atrophy and weakness induced by disuse in mice.