bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Gain Artificial Magnetic Conductor Integrated Antenna for Wi-Fi 6E/Automotive Radar Systems Applications
Authors: Kanuri Naveen , Damera Vakula 
Published: February 2024

Abstract
This article presents a compact and high-gain novel p-shape triple-band printed monopole antenna. The proposed antenna is made of a p-shaped monopole radiator with rectangular slot etched on the radiating arm. The slots create triband resonance frequencies. The antenna is also integrated with a novel artificial magnetic conductor (AMC) to achieve high gain. The AMC is implemented with a rectangular structure and has zero phase reflection characteristics, which helps to improve the antenna gain. The proposed antenna resonates at 1.18 GHz, 6 GHz, and 9.4 GHz. The proposed antenna has an improved gain of 6.75dBi. The proposed antenna structures are fabricated and measured peak gain, S11, and radiation pattern are compared with the simulation results. The proposed antenna operates at 6GHz for Wi-Fi 6E connectivity, operates at 1.18 GHz for GPS navigation, and operates at 9.4 GHz for automotive radar systems for collision avoidance.
Automatic Localization of Cochlear-Implant-Electrodes using Cone Beam Computed Tomography Images
Authors: Thormählen Jasmin , Krüger Benjamin , Nogueira Waldo 
Published: February 2024

Abstract
Background: Cochlear implants (CI) are implantable medical devices that enable the perception of sounds and the understanding of speech by electrically stimulating the auditory nerve in case of inner ear damage. The stimulation takes place via an array of electrodes surgically inserted in the cochlea. After CI implantation, cone beam computed tomography (CBCT) is used to evaluate the position of the electrodes. Moreover, CBCT is used in research studies to investigate the relationship between the position of the electrodes and the hearing outcome of CI user. In clinical routine, the estimation of the position of the CI electrodes is done manually, which is very time-consuming.
Results: The aim of this study was to optimize procedures of automatic electrode localization from CBCT data following CI implantation. For this, we analyzed the performance of automatic electrode localization for 150 CBCT data sets of 10 different types of electrode arrays. Our own implementation of the method by Noble et al. 2015 for automated electrode localization served as a benchmark for evaluation. Differences in the detection rate and the localization accuracy across types of electrode arrays were evaluated and errors were classified. Based on this analysis, we developed a strategy to optimize procedures of automatic electrode localization.
It was shown that particularly distantly spaced electrodes in combination with a deep insertion can lead to apical-basal confusions in the localization procedure. This confusion prevents electrodes from being detected or assigned correctly, leading to a deterioration in localization accuracy.
Conclusions: We propose an extended cost function for automatic electrode localization methods that prevents double detection of electrodes to avoid apical-basal confusions. This significantly increased the detection rate by 11.15 percent points and improved the overall localization accuracy by 0.53 mm (1.75 voxels). In comparison to other methods, our proposed cost function does not require any prior knowledge about the individual cochlea anatomy.
Spatio-Temporal Modelling for Downscaling Long-Range Daily Precipitation Forecasts at Unmonitored Sites
Authors: Bakar K. Shuvo , Jin Huidong , Shao Quanxi , Li Ming , Dobrohotoff Peter , Powell Andrea 
Published: February 2024

Abstract
Downscaling low-resolution long-range climate forecasts to specific sites, in the absence of historical observations, poses a challenge yet holds significant value for weather-sensitive sectors. Existing methods for statistical downscaling and climatological forecasts, however, necessitate site-specific observations. In this study, we propose a novel solution for generating daily precipitation forecasts at any unmonitored site. We introduce a Bayesian non-stationary truncated spatio-temporal model that uses data from meteorological stations within its surrounding region. The model employs a truncated random process to handle dry days and utilises a Gaussian-process-based spatio-temporal stochastic process to capture non-stationary spatial dependencies. Besides utilising ensemble seasonal forecasts and hindcasts from a climate model, it also incorporates Quantile Mapping (QM) downscaled long-range forecasts for these stations. Our proposed model, Spatio-Temporal Forecast downscaling with QM (STFQM), is employed to downscale climate forecasts from ACCESS-S1 (Australian Community Climate and Earth-System Simulator – Seasonal, version 1) at a 60km spatial resolution to any site within the Murray-Darling basin, Australia. Through comprehensive leave-one-station-out cross-validation, our model demonstrates superior performance in one-month lead time forecasts compared to both the raw ACCESS-S1 forecasts and their QM downscaled counterparts, in terms of accuracy, reliability, and overall ensemble forecast skill. Furthermore, our results illustrate that STFQM is on par with Climatology, a benchmark for seasonal forecasts. Our innovative approach complements existing statistical downscaling techniques, eliminating the need for site-specific observations while providing high-quality localised precipitation forecasts.
Toripalimab plus chemotherapy and radiotherapy for treatment-naive, advanced esophageal squamous cell carcinoma: A single-arm phase II trial
Authors: Wu Lei , Li Baisen , Wan Gang , Wang Yi , Zhu Jie , Liang Long , Leng Xuefeng , He Wenwu , Peng Lin , Han Yongtao , He Shuya , Wang Dongsheng , Zhou Yehan , Yi Liang , Zhang Wencheng , Pang Qingsong , Zhang Wei , Li Tao , Lang Jinyi , Liu Yang , Cao Bangrong , Wang Qifeng 
Published: February 2024

Abstract
Background
The effectiveness of chemo-immunotherapy for advanced esophageal squamous cell carcinoma (ESCC) remains limited. Therefore, we evaluated the safety and efficacy of radiotherapy plus chemo-immunotherapy as a first-line therapy for advanced ESCC.
Methods
In this single-arm clinical trial, individuals aged 18–75 years with previously untreated stage IV ESCC received chemotherapy comprising four cycles of 135–175 mg/m2 paclitaxel with carboplatin every three weeks. Toripalimab (240 mg) was intravenously infused every three weeks for 12 months or until disease progression or intolerable toxicity. Radiotherapy commenced in the third cycle, encompassing radiation (50–50.4 Gy in 25–28 fractions) to primary lesions and metastases (30–40 Gy in 3–5 fractions). The primary outcome was progression-free survival (PFS), and secondary outcomes were objective response rate (ORR), disease control rate (DCR), duration of remission (DoR), one- and two-year overall survival rates, and adverse events.
Results
In this study, 33 participants (29 men; median age 59 years) were enrolled. Ultimately, 26 patients (78.8%) completed the entire radio-chemotherapy course, achieving an ORR, DCR, and DoR of 57.7% (95% CI: 37.3–78.0), 73.1% (95% CI: 54.8–91.3), and 11.5 months (IQR, 6.4–15.0 months), respectively. Within a median follow-up of 22.2 months, the median PFS was 12.8 months. Lymphopenia was the most frequent grade ≥ 3 adverse event (82%), and esophageal fistula occurred in three patients (9.1%). No treatment-related deaths occurred.
Conclusion
Radiotherapy supplementation to first-line chemo-immunotherapy for treatment-naive advanced ESCC demonstrated substantial antitumor activity and manageable safety, warranting further randomized controlled trials.
Trial Registration:
http://www.chictr.org.cn/showproj.aspx?proj=126830 , identifier ChiCTR2100046715.
The Relationship between Medication Beliefs, Patient Activation, and Self-Rated Health in Patients Taking Oral Anticancer Agents
Authors: Hwang Misun , Cho Youmin , Gong Yang , Jiang Yun 
Published: February 2024

Abstract

Purpose: Patients on oral anticancer agent (OAA) therapies have the autonomy to manage their cancer treatments in home settings. However, patients may not have adequate knowledge, confidence, or ability to effectively manage OAA-related consequences, such as severe side effects, which can significantly impact their treatment and health outcomes. This study aims to identify the associations between medication beliefs, patient activation, and self-rated health (SRH) among oncology patients taking OAAs and explore the potential mediation effects of patient activation on the relationship between medication beliefs and SRH.
Methods: A secondary data analysis was conducted on cross-sectional data from 114 patients who were taking or had previously taken OAAs and were diagnosed with breast, colorectal, lung, or prostate cancer. Descriptive statistics, bivariate correlation, hierarchical multiple linear regression, and mediation analysis were conducted.
Results: The results indicate that patients taking OAAs have ambivalent attitudes toward medication. Both medication necessity and concerns were negatively associated with SRH, while patient activation was positively associated with SRH. Patient activation had a negative association with medication concerns and fully mediated the relationship between medication concerns and SRH in patients taking OAAs.
Conclusion: The findings highlight the significance of activating patients to better understand and manage their OAAs. It is crucial for oncology professionals to provide multifaceted interventions to promote patient activation with an effort to mitigate the negative impact of medication beliefs on patient-perceived health outcomes.
Clinical application of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization in thoracoscopic lung nodule resection: A single-centre retrospective study
Authors: Zhu Xiao , Chen Zhi , Zhu Kun-Lun , Zhou Shao , Xing Fu-Bao , Chen Wen-Bang , Zhang Lei 
Published: February 2024

Abstract
Background
To evaluate the clinical value of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization in thoracoscopic lung nodule resection.
Methods
We retrospectively collected the clinical data of 120 patients who underwent lung nodule localization and resection surgery at the Department of Thoracic Surgery, First Affiliated Hospital of Bengbu Medical College, from January 2020 to January 2022. Among them, 30 patients underwent CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization, 30 patients underwent only CT-assisted body surface localization, 30 patients underwent only intraoperative stereotactic anatomical localization, and 30 patients underwent CT-guided percutaneous microcoil localization. The success rates, complication rates, and localization times of the four lung nodule localization methods were statistically analysed.
Results
The success rates of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization and CT-guided percutaneous microcoil localization were both 96.7%, which were significantly higher than the 70.0% success rate in the CT-assisted body surface localization group (P < 0.05). The complication rate in the combined group was 0%, which was significantly lower than the 60% in the microcoil localization group (P < 0.05). The localization time for the combined group was 17.73 ± 2.52 min, which was significantly less than that (27.27 ± 7.61 min) for the microcoil localization group (P < 0.05).
Conclusions
CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization is a safe, painless, accurate, and reliable method for lung nodule localization.
Evaluation of smooth reaction rate of noisy experimental data using Legendre series expansion
Authors: Aghili Alireza , Shabani Amir Hossein 
Published: February 2024

Abstract

The accurate calculation of reaction rates from experimental data is crucial for understanding and characterizing chemical processes. However, the presence of noise in experimental data can introduce errors in rate calculations. In this study, we introduced a novel approach that utilizes the Legendre series expansion method to directly derive smooth reaction rates from noisy experimental data, eliminating the need for numerical differentiation methods. This approach proves to be highly effective in handling noisy thermogravimetric analysis (TGA) data obtained from the thermal decomposition of specific polymers. We demonstrated the robustness and reliability of this method and provided Gnu Octave codes as a free alternative to MATLAB, making the implementation more accessible. Furthermore, the smooth reaction rates obtained were used to evaluate the activation energy using the Friedman isoconversional method. The results showed excellent agreement with those obtained using the Vyazovkin integral method. Additionally, the proposed method can be applied to obtain smooth derivative thermogravimetric (DTG) curves using noisy TGA data set.
MSC Classification: 41A10 , 41A58 , 42C10 , 65D25 , 65D30 , 80A30
Ultra-wide measurement range D-shaped photonic crystal fiber sensor based on surface plasmon resonance
Authors: Zhang Shuhuan , Yang Ying , Dong Jiyu 
Published: February 2024

Abstract
In this paper, a kind of D-type photonic crystal fiber (PCF) sensor with an ultra-wide detection range based on micro-opening gold film coating is proposed. This sensor allows for the sensing detection of the refractive index (RI) of the analyte ranging from 1.30 to 1.42. However, the sensor coated with a micro-opening gold film only achieves an average wavelength sensitivity of 1489 nm/RIU in the x-polarization direction. To improve the performance of the sensor, an attempt was made to replace the micro-opening gold film with MoO2 nanofilm. After simulation calculation, it was found that the RI detection range of the sensor using MoO2 nano-film became 1.33–1.39. Excitingly, the average wavelength sensitivity in the x-polarized direction reaches 17, 178 nm/RIU, which is 11.5 times better than the original sensor. This implies that the sensor is more sensitive to changes in the RI and can provide more accurate sensing and detection results. It has been demonstrated that the performance of a D-type PCF sensor can be significantly improved by using MoO2 nanofilm. This improvement helps to expand the application domain of sensors and enhance the accuracy of sensing detection. We believe that this research result has important implications for the development of fiber sensor technologies.
Regulation of alternative splicing of lipid metabolism genes in sepsis-induced liver damage by RNA-binding proteins
Authors: Abuduaini Buzukela , Jiyuan Zhang , Rehati Aliya , Liang Zhao , Yunlin Song 
Published: February 2024

Abstract

Background:RNA binding proteins (RBPs) have the potential for transcriptional regulation in sepsis-induced liver injury, but precise functions remain unclear.
Aim: To conduct a genome-wide expression analysis of RBPs and illuminate changes in regulation of alternative splicing in sepsis-induced liver injury.
Method: RNA-seq data on "sepsis and liver" from the publicly available NCBI dataset was analyzed, and differentially expressed RBPs and alternative splicing events (ASEs) in healthy and septic liver were identified. Co-expression analyses of sepsis-regulated RBPs and ASEs were performed. Models of sepsis were established to validate hepatic RBP gene expression patterns with different treatments.
Result: Pairwise analysis of gene expression profiles of sham, cecum ligation puncture (CLP) and CLP with dichloroacetate (CLPDCA) mice allowed 1208 differentially expressed genes (DEGs), of which 800 were upregulated and 408 downregulated, to be identified. DEGs were similar in both CLP and CLPDCA mice. A further 67 upregulated and 58 downregulated DEGS were identified by comparison of sham and CLPDCA groups. GO functional analysis showed DEGs to be enriched in immune and inflammatory-related processes and KEGG analysis showed that lipid metabolism-related pathways were downregulated. Differences in lipid metabolism-related alternative splicing events, including A3SS, were also found in CLP and CLPDCA compared with sham mice. Thirty-seven RBPs, including S100a11, Ads2, Fndc3b, Fn1, Ddx28, Car2, Cisd1 and Ptms, were differentially expressed in CLP mice and shown to be enriched in lipid metabolic and immune /inflammatory-related processes by GO functional analysis. The models of sepsis were constructed with different treatment groups and S100a11 expression in the CLP group found to be higher than in the sham group, a change that was reversed by DCA. The alternative splicing ratio of Srebf1 and Cers2 decreased compared with the Sham group increased after DCA treatment.
Conclusion: Abnormal profiles of gene expression and alternative splicing were associated with sepsis-induced liver injury. Unusual expression of RBPs, such as S100a11, may regulate alternative splicing of lipid metabolism-associated genes, such as Srebf1 and Cers2, in the septic liver. RBPs may constitute potential treatment targets for sepsis-induced liver injury.
Horizontal and vertical variations in soil properties under different pruning regimes in Albizia procera and Hardwickia binata based agroforestry systems under semi-arid conditions
Authors: Prasad Rajendra , Shukla Ashok , Arunachalam A. , Singh Prashant , Gupta Ajit , Newaj Ram , Singh Ramesh , Saroj N. K. , Tripathi V. D. , Debnath Sovan 
Published: February 2024

Abstract
Trees’ canopy pruning is one of the most important management practices in agroforestry that allows understory crops to receive adequate sunlight. The effect of pruning on the productivity of intercrops is well known; however, information on its effect on soil properties is scanty. Hence, studies were conducted to determine 1) whether canopy pruning has any effect on soil properties and 2) what level of pruning should be adopted in selected agroforestry systems. Two separate agroforestry models, based on Albizia procera (10-year-old) and Hardwickia binata (20-year-old), were selected for the study, which included three factors: pruning level (0, 50 and 75%), sampling location (under and outside canopy) and soil depth (0–15 and 16–30 cm), each of which was replicated three times in a completely randomized block design. Canopy pruning yielded varying effects on the studied soil parameters without any definite relationship with pruning levels. Sampling location and soil depth had a significant effect on the studied parameters. Their values were found to be higher and favorable in the upper soil and under the tree canopy. The findings revealed that unpruned trees of A. procera caused the maximum improvement in soil, followed by trees subjected to 50 and 75% crown pruning, while in the case of H. binata, improvement in soil health in 50% pruning over no pruning was noticeable, but similar improvement in 75% pruning over 50% was not so prominent, implying that heavy pruning (75%) should be avoided to keep evapotranspiration under control. Thus, the study concludes that a moderate level of pruning (50%) is desirable in A. procera and H. binata based agroforestry under semi-arid conditions for efficient use of above- and below-ground resources and improved soil health.
Investigation of the Rate of Benign Histology and Related Factors in Clinical Stage T1 Kidney Tumors Tİtle
Authors: Yıldız Serkan , Yılmaz Muhammet Şahin , Kokurcan Alihan , Cavıldak İdris Kıvanç , Baylan Burhan , Gök Alper , İmamoğlu Muhammet Abdurrahim 
Published: February 2024

Abstract
Purpose: To compare the relationship between a benign pathology of preoperative parameters of renal masses <7cm (T1) in diameter.
Methods: Between January 2007 and June 2016 and applied to radical nephrectomy, nephron sparing surgery for renal masses < 7 cm (T1) were evaluated retrospectively. Age, sex, tumor size, tumor location, laterality, symptomatology, tumor endophytic / exophytic whether or not the tumor cystic / solid whether or not, smoking history and comorbidities were compared in terms of pathology results.
Results: A total of 243 patients, 58 (23%) were benign pathology. Female sex (63%) were significantly higher rate of benign pathology (p = 0.004). 60% of patients with benign pathology was observed that 44% of symptomatic patients with malignant pathology (p = 0.033). We found symptomatic benign pathology that 60% of patients and malignant pathology in 44% of patients (p = 0.033). Pain as a symptom was associated with benign pathology (51.7%). 1-2 cm, 2-3 cm, 3-4 cm benign pathology of renal masses rates were 33%, 20%, 12.5%, respectively. In this study; age, tumor size, tumor location, laterality, tumor endophytic / exophytic whether or not the tumor cystic / solid whether or not, smoking history and comorbidities were observed pathological results to impact not significantly.
Conclusion: In our study, symptomatic and female sex in small renal masses appeared benign pathology markers. As a result, predictors before surgery may be considered due to the high rate of benign pathology of small renal masses.
An economic model to understand the cost-effectiveness of olanzapine orally dispersible tablets (ODT) and olanzapine film coated tablets as a group compared with other oral atypical antipsychotics for treating schizophrenia in Morocco
Authors: Tazi Ahmed , Errachidi Prof. Faouzi , Sonawane Dipesh , Tahri Ghizlane , Rao Sameer , Mehta Suyog 
Published: February 2024

Abstract

Background:
Antipsychotic medications are the primary treatment for schizophrenia, with olanzapine being an effective medication for schizophrenia. The economic cost for each individual with schizophrenia is high, with antipsychotic medication being a major expense. This study aims to develop an economic decision model that compares different treatment options for schizophrenia patients, including olanzapine Orally Dispersible Tablets (ODT), olanzapine [ODT + Standard Oral Tablet (SOT)], risperidone (ODT + SOT), and aripiprazole (ODT + SOT), to determine their cost-effectiveness with an objective to optimize healthcare resource allocation in Morocco.
Methods:
The study used published medical literature and a clinical expert panel to develop a decision analytic model. This model was designed to capture parameters such as adherence levels, treatment discontinuation, relapse with and without hospitalization, quality-adjusted life years (QALYs), treatment-related adverse events, healthcare resource utilization, and associated costs. The main outcomes of interest included the total annual direct cost per treatment, QALYs, and incremental cost-effectiveness ratio (ICER) per 1 QALY gained. One-way and probabilistic sensitivity analyses were employed to account for parameter uncertainty.
Results:
According to the simulation model, the ODT and ODT + SOT as a group form of olanzapine was the most effective treatment option in terms of a lowest percentages of inpatient relapse, and patients who remained stable (11% and 79% respectively) than risperidone (19% and 62% respectively) and aripiprazole ODT (26% and 50% respectively) and ODT + SOT formulation groups. Olanzapine (ODT + SOT) therapy group was cost-effective when compared to the combined group of ODT + SOT forms of risperidone (ICER: Moroccan Dirham (MAD) 103,907), and aripiprazole (ICER: MAD 65,047). Additionally, olanzapine ODT was found to be cost-effective compared to olanzapine SOT with an ICER of MAD 3,921, risperidone ODT with an ICER of MAD 1,02,298, risperidone SOT with an ICER of MAD 31,088, and aripiprazole ODT or SOT formulations. All the above ICERs fall under the willingness-to-pay threshold in Morocco of MAD 250,832.40. Sensitivity analyses confirmed the reliability of the findings.
Conclusions:
The model concluded that olanzapine ODT is the most cost-effective first-line treatment option for schizophrenia in Morocco when compared to other atypical antipsychotic medications in ODT and SOT formulations.