bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of digitalization in agricultural cooperatives successful functioning
Authors: Golovina S. G. , Ruchkin A. V. , Abilova E. V. 
Published: October 2023

Relevance. The widespread use of digital opportunities by modern cooperatives in their multifunctional activities is of genuine interest to both scientists and practitioners, in connection with which there are noteworthy scientific publications and analytical (coming from the cooperators themselves) reviews. It is important that cooperative organizations, both small, important for the regional economy, and large, business-oriented, use digital solutions not only to increase their competitiveness (for purely economic purposes), but also to overcome social and environmental problems that arise in rural areas due to biological, climatic and geopolitical challenges.Methods. To achieve the goal outlined in the work (identifying the potential of digitalization in ensuring high performance of cooperatives and, through their activities, sustainable development of rural areas), review and analytical methods based on a rigorous study of the results of theoretical research and reporting materials of large cooperatives were applied. having official websites and publishing their strategic and reporting documents on them. The analysis, primarily from the standpoint of the suitability of international experience for domestic practice, was subject to the information of the International Cooperative Alliance (International Cooperative Alliance, ICA), reflecting the positive practices of digitalization of cooperative activities in various countries of the world, as well as the difficulties faced by agricultural cooperatives in the new (digital) environment. The basis for empirical research and, consequently, for the application of quantitative methods in them was the generalized materials of sociological surveys organized within the boundaries of the subjects of the Ural Federal District, mainly in the Sverdlovsk Region.Results. The main results of the study include the specification of aspects of cooperative activity obtained in its process, in which digitalization is especially important and promising, as well as those that are preferable for implementation in the previous (traditional for cooperatives) forms. Of no less importance is the designation of the main problems and difficulties that stand in the way of creating a full-fledged digital space directly for agricultural cooperatives as a result of the peculiarities of agricultural production, the specifics of the conditions of rural life, the uniqueness of rural areas (their position and characteristics). As such, they noted, firstly, the limited investment opportunities of cooperatives in the creation and development of digital infrastructure facilities in the countryside, secondly, the digital divide (different preparation of villagers for the use of digital technologies), thirdly, some contradictions between modern (digital) formats of cooperative activities and the classical principles of its organization.
Physico-chemical parameters of milk of cows with different proportions of blood in the Holstein breed
Authors: Gorelik A. S. , Rebezov M. B. , Gorelik O. V. 
Published: October 2023

Relevance. Providing the countryʼs population with high-grade food products of its own production is an important task facing the workers of the country›s agro-industrial complex. Milk is such a product. Milk is not only a valuable food product, but also a raw material for the dairy industry. Cattle are one of the main sources of milk, so the study of cowsʼ milk is an urgent task. The aim of the work was to study the physicochemical and sanitary-hygienic indicators of milk of cows of different genotypes by blood relative to the Holstein breed.Results. As a result of the research, it was found that the best content of dry matter and its components was milk obtained from cows with a Holstein genotype of 75–91%. In our opinion, this is explained by the effect of reversion to the mean in animals of this group and, to some extent, by the effect of heterosis, which manifested itself when crossing Black-and-White cows and Holstein bulls. Animals with a higher level, ranging from 91% to 97% for Holsteins, had the lowest values in terms of the content of dry matter and its components in milk. In the 4th group, where there were practically purebred cows with a blood ratio of 97% or more according to Holstein, an increase in the dry matter in milk relative to the 3rd group was found.
The Important Role of MSMEs in National Economic Development
Authors: Handoko A.D , Pramono Nindyo , Siregar Mahmul , Nasution Mirza , Barus Utary Maharany 
Published: October 2023

ABSTRACT

Member countries of the Organisation for Economic Co-operation and Development (OECD), make MSMEs a default factor in every economic law, especially investment law. However, the role of MSMEs in Indonesia is still often underestimated and has not received adequate opportunities to play their role in national economic development. The main problem in this research is to question how the issue of providing opportunities for the development of MSMEs in the rule of law in the economic sector in Indonesia. By using the normative juridical legal research method, it appears that MSMEs have an important role in national economic development, and therefore become an important target in efforts to achieve the State's Goal in promoting general welfare. The data collection technique in this study uses secondary data with qualitative data analysis techniques. From this research, it was found that there is an awareness of the importance of the role of MSMEs in national economic development, which is contained in various policies and legal regulations. The problem is that the implementation of these policies and regulations are still not in line with expectations. From the results of this research, it is recommended that the Government of Indonesia to reform the investment law in which it is mandated to provide opportunities for the development of MSMEs, so that MSMEs can really play an important role in the national economic development.

Keywords : investment law, national economic development, role of MSMEs, legal reform;
PENGEMBANGAN INSTRUMEN DAN EVALUASI PEMAHAMAN PRODUK BAGI DIVISI PENJUALAN MENGGUNAKAN QUIZIZZ PADA PT. ACTiV
Authors: Wijaksono Bahtera Alam , Fazrie Mohammad , Parulian Dudi 
Published: October 2023

The development of the industrial revolution 4.0 make technology is improvement, because of that make so many things activities all fields become very simple, especially in companies engaged in the IT sector. Seeing these conditions need to upgrade the capabilities of new and old personnel, specifically for the sales force. By seeing this the team became very interested making an activity that could improve the quality and performance of the personnel by providing evaluation and training, which is expected in the future to be able to help in carrying out their duties. This community service aims to be able to provide good utilization for the company in the future. The team will use Quizizz an e-learning media delivery because attractive and interactive and for the research method used the Quasi Experimental Design. For the evaluating of a product and for the medium purposive sampling we are using documentation, observasion, pretest and posttest, for data used in making these questions category volume, profitability, product and other relevant measures. The final results from material carried out by the team the results quite 85% - 95% in very good category. The conclusion from this study is that e-learning using Quizizz is very effective in improving the ability, which previously got enough marks very good at the assessment and Quizizz can be used as a data bank, which can be used continuously as a media e-learning for other staff at PT. Alfa Cipta Technology Virtual (ACTiV).
Disorders of mental health in children and adolescents with hematological malignancies
Authors: Kravchenko N. E. , Suetina O. A. , Sachuk O. V. , Valiev T. T. 
Published: October 2023

Introduction. The success in pediatric oncohematological disorders treatment cause increasing scrutiny not only to remission achievement and long-term patient survival, but also to supportive dysfunctions, which go with malignancy and anti-tumor treatment. Blood tumors cause all organs and systems disorders, and psychic dysfunctions of these are not in the last place.Aim. To characterize mental health and psychic disorders types in children and adolescents with oncohematological diseases during hospital stay.Materials and methods. It was analyzed mental health of 169 children and adolescents with hemoblastoses, who were treated at Pediatric Oncology and Hematology Research Institute of National Research Cancer Centre n. a. N. N. Blokhin (Moscow, Russia) in 2022 year. 50 (29.6 %) patients needed a psychiatric consultation. Among oncohematological disorders acute lymphoblastic leukemia was predominated – 25 (50 %), lymphomas – 17 (34 %) and acute myeloid leukemia – 8 (16 %) patients. Mental health data assessed after examination/consultation of clinical psychologist and psychiatrist.Results. Asthenia was found in all 50 (100 %) patients, who were recommended a psychiatrist consultation, in 47 (94 %) – adjustment disorder, in 15 (30 %) – vexatious and neurotic disorder, in 16 (32 %) – affective syndromes, less often (18 and 14 % respectively) – behavioral deviations and eating disorders. As single cases in 2 (4 %) patients an intellectual disability and in 1 (2 %) a psychotic syndrome were diagnosed. As a role the most pronounced psychopathological conditions were upon admission to the hospital and decreased during the treatment and adaptation.Conclusions. One third of children and adolescents, hospitalizing to oncohematological clinic need a psychiatrist consultation. Multidisciplinary care for such patients with pediatric oncologist, psychiatrist and clinical psychologist can cure psychogenic disorder effectively, improving the stay of patient at the hospital and best compliance between the doctor and patient.
Real-time video analysis allows the identification of large vessel occlusion in patients with suspected stroke: feasibility trial of a “telestroke” pathway in Northwestern Switzerland
Authors: Thilemann Sebastian , Traenka Christoph Kenan , Schaub Fabian , Nussbaum Lukas , Bonati Leo , Peters Nils , Fladt Joachim , Nickel Christian , Hunziker Patrick , Luethy Marc , Schädelin Sabine , Ernst Axel , Engelter Stefan , De Marchis Gian Marco , Lyrer Philippe 
Published: October 2023

Background and aimLoss of time is a major obstacle to efficient stroke treatment. Our telestroke path intends to optimize prehospital triage using a video link connecting ambulance personnel and a stroke physician. The objectives were as follows: (1) To identify patients suffering a stroke and (2) in particular large vessel occlusion (LVO) strokes as candidates for endovascular treatment. We have chosen the Rapid Arterial Occlusion Evaluation (RACE) scale for this purpose.MethodsThis analysis aimed to verify the feasibility of prehospital stroke identification by video assessment. In this prospective telestroke cohort study, we included 97 subjects, in which the RACE score (items: facial palsy, arm and leg motor function, head and gaze deviation, and aphasia or agnosia) was applied, and the assessment videotaped by a trained member of the Emergency Medical Services (EMS) in the field using a mobile device. Each recorded patient video was independently assessed by three experienced stroke physicians from a certified stroke center and compared to the neuroimaging gold standard. Within this feasibility study, the stroke code was not altered by the outcome of the RACE assessment, and all patients underwent the standard procedures within the emergency unit.ResultsWe analyzed 97 patients (median age 78 years, 53% women), of whom 51 (52.6%) suffered an acute stroke, 12 (23.5%) of which were due to an LVO and 46 patients had symptoms mimicking a stroke. The sensitivity of stroke identification was 77.8%, and specificity was 53.6%. In regard to the identification of an LVO, sensitivity was 69.4% and specificity was 84.3%. The inter-rater agreement in the RACE-score assessment was ICC = 0.82 (intraclass-correlation coefficient).ConclusionThese results confirm our hypothesis that the local telestroke concept is feasible. It allows correct (i) stroke and (ii) LVO identification in the majority of the cases and thus has the potential to assist in efficient prehospital triage.
Implementing stroke care in a lower-middle-income country: results and recommendations based on an implementation study within the Nepal Stroke Project
Authors: Tunkl Christine , Paudel Raju , Bajaj Sunanjay , Thapa Lekhjung , Tunkl Patrick , Chandra Avinash , Shah Bhupendra , Karmacharya Balgopal , Subedi Ashim , Jalan Pankaj , Ghimire Pradesh , Ghimire Mahesh Raj , Dorje Gampo , Begli Nima Haji , Golenia Jessica , Gajurel Bikram Prasad , Shreyan Shirsho , Sharma Nooma , Krauss Alexandra , Pandian Jeyaraj , Fischer Thomas , van der Merwe Jan , Wick Wolfgang , Hacke Werner , Gumbinger Christoph 
Published: October 2023

BackgroundGlobally, the majority of strokes affect people residing in lower- and lower-middle-income countries (LMICs), but translating evidence-based knowledge into clinical practice in regions with limited healthcare resources remains challenging. As an LMIC in South Asia, stroke care has remained a healthcare problem previously unaddressed at a national scale in Nepal. The Nepal Stroke Project (NSP) aims to improve acute stroke care in the tertiary healthcare sector of Nepal. We hereby describe the methods applied and analyze the barriers and facilitators of the NSP after 18 months.MethodsThe NSP follows a four-tier strategy: (1) quality improvement by training healthcare professionals in tertiary care centers; (2) implementation of in-hospital stroke surveillance and quality monitoring system; (3) raising public awareness of strokes; and (4) collaborating with political stakeholders to facilitate public funding for stroke care. We performed a qualitative, iterative analysis of observational data to analyze the output indicators and identify best practices.ResultsBoth offline and online initiatives were undertaken to address quality improvement and public awareness. More than 1,000 healthcare professionals across nine tertiary care hospitals attended 26 stroke-related workshops conducted by Nepalese and international stroke experts. Monthly webinars were organized, and chat groups were made for better networking and cross-institutional case sharing. Social media-based public awareness campaigns reached more than 3 million individuals. Moreover, live events and other mass media campaigns were instituted. For quality monitoring, the Registry of Stroke Care Quality (RES-Q) was introduced. Collaboration with stakeholders (both national and international) has been initiated.DiscussionWe identified six actions that may support the development of tertiary care centers into essential stroke centers in a resource-limited setting. We believe that our experiences will contribute to the body of knowledge on translating evidence into practice in LMICs, although the impact of our results must be verified with process indicators of stroke care.
Is there a role for traditional and complementary medicines in managing chronic fatigue? a systematic review of randomized controlled trials
Authors: Li Yuxiao , Yang Jingya , Chau Chi Ian , Shi Junnan , Chen Xianwen , Hu Hao , Ung Carolina Oi Lam 
Published: October 2023

Introduction: Chronic fatigue syndrome (CFS) is an increasingly common condition that is challenging to treat due to unclear etiology and a lack of consensus on clinical diagnosis and treatment guidance. Many affected people resorted to using traditional and complementary medicines (T&amp;CMs). However, the evidence for T&amp;CMs for CFS has been inconclusive and continues to evolve. The study aims to identify, summarize and assess the most recent evidence on the efficacy and safety of T&amp;CMs for CFS.Methods: Randomized controlled trials (RCTs) investigating T&amp;CMs for CFS published in English of Chinese between 1 January 2013 and 31 December 2022 were searched from 7 databases. RCTs comparing T&amp;CMs with no treatment, placebo, or pharmacological medicine were included, irrespective of language or blinding. The Consolidated Standards of Reporting Trials Statement extensions for Chinese herbal medicine Formulas (CONSORT-CHM) and the Cochrane Collaboration’s Risk of Bias tool were used to evaluate the quality and risk of bias of included studies.Results: A total of 62 RCTs investigating 43 types of T&amp;CMs and involving 5,231 participants with CFS were included in this review. The primary outcome measures mainly included the scoring of fatigue symptoms using the validated tool Fatigue Scale-14 (FS-14) or the TCM syndrome score. The main interventions showing overall efficacy were Chaihu Guizhi Decoction and Buzhong Yiqi combined with Xiao Chaihu Decoction, and 148 ingredients were identified, including Astragali Radix, Glycyrrhizae Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma, and Bupleuri Radix. The most significant effect was the improvement of fatigue, followed by TCM-diagnosed symptoms and other psychological conditions. No serious adverse effect had been reported. However, the quality of the RCTs included RCTs were found to be suboptimal, and the risk of bias remained uncertain.Conclusion: Some evidence from RCTs supported the efficacy and safety of T&amp;CM in CFS. However, given the methodological and quality heterogenicity of the included studies, the recommendations of T&amp;CMs in treating CFS remain inconclusive. To develop better quality evidence about T&amp;CMs for CFS, future studies should employ more objective diagnosis standards and outcome measurements, larger sample size, and better bias control, and ensure the compliance with the corresponding reporting guidelines.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022362268, identifier CRD42022362268.
The Effect of Plant Growth-Promoting Rhizobacteria on Soil Properties and the Physiological and Anatomical Characteristics of Wheat under Water-Deficit Stress Conditions
Authors: Alaskar Abdulaziz A. , AL-Shwaiman Hind A. 
Published: October 2023

This study aimed to evaluate the effects of plant growth-promoting Rhizobacteria (PGPR) treatments, B1, Azosprillium lipoferum Sp2 and B2, A. lipoferum Sp2 + Pseudomonas sp. SARS12, as well as inorganic nitrogen doses (60, 100, 140 and 180 kg N ha–1) on some soil physical characters, physiological, anatomical and yield parameters as well as nitrogen use efficiency (NUE) of wheat under water deficit stress. Results showed that water stress significantly decreased physiological characters such as chlorophyll content (6.7 and 9.8%) and relative water content (13.7 and 11.2%) in both seasons, respectively. Nevertheless, proline and malondialdehyde (MDA) were increased significantly (26.9, 12.3% and 90.2, 96.4%) in both seasons, respectively, as signals for water stress. The anatomical characteristics of flag leaves were negatively affected. Inoculation of wheat grains with PGPR significantly increased field capacity and RWC, adjusted enzymes’ activity and thus improved the physiological and yield traits and NUE as well as improving the anatomical features of flag leaves. Moreover, the combination of integrated PGPR and 140 kg N ha−1 significantly improved grain yield and its components as well as grain N uptake in comparison to control treatments. In conclusion, PGPR improved wheat productivity and NUE; they are an eco-friendly and cost-effective approach for improving plant production, and reducing nutrient leaching hazards and the negative impact of water stress.
Antioxidants in the Treatment of Diseases in Children (Pros and Cons)
Authors: Юрьева Э.А. , Длин В.В. , Кушнарева М.В. , Шабельникова Е.И. 
Published: October 2023

Нарушение окислительно-восстановительных процессов в митохондриях с преобладанием окислительной активности характерно для всех болезней, особенно в детском возрасте при возможной незрелости функций компонентов антиоксидантной защиты от стресса. В начале стрессорного воздействия на организм окислительная «вспышка» необходима для адаптации к предъявляемому воздействию. Однако при избыточной силе окислительного стресса эта реакция приводит к истощению антиоксидантной системы, что требует ее заместительной терапии. Остается дискутабельным вопрос о том, какие антиоксиданты применять с лечебной целью, в каком количестве, в каких сочетаниях, в какие патогенетические периоды и как длительно их использовать. Этот вопрос связан с возможным нежелательным действием антиоксидантов при передозировках. Представлены наиболее употребляемые антиоксиданты и средства защиты окислительно-восстановительной цепи митохондрий при стрессе.
Violation of redox processes in mitochondria with a predominance of oxidative activity is characteristic of all diseases, especially in childhood, with the possible immaturity of the functions of the components of antioxidant protection against stress. At the beginning of the stress effect on the body, an oxidative "flash" is necessary for adaptation to the exposure. However, with excessive oxidative stress, this reaction leads to the depletion of the antioxidant system, which requires its replacement therapy. It remains debatable the question of which antioxidants to use for therapeutic purposes, in what quantity, in what combinations, in what pathogenetic periods, and how long to use them. This issue is related to the possible undesirable effects of antioxidants in overdoses. The most commonly used antioxidants and means of protecting the redox chain of mitochondria under stress are presented.
Investigation of Features of Mass-Fragmentation of Some N-(N,N-diethylacetamidino)-O-alkylfluorophosphates and Related Alkylfluorophosphonates and their Detection by Liquid Chromatography-High Resolution Mass Spectrometry
Authors: Braun A. V. , Rybalchenko I. V. , Fateenkov V. N. , Yashkir V. A. 
Published: October 2023

The timely detection of violations of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction (CWC) requires reliable methods for detecting toxic chemicals that can be used for chemical attacks. The purpose of this investigation is to estimate chromatographic and mass-spectral characteristics of some toxic chemicals recently included into Schedule 1 of the Annex on Chemicals of the CWC, in particular N-(N,N-diethylacetamidino)-methylfluorophosphonate (DEAMP), N-(N,N-diethylacetamidino)-O-methylfluorophosphate (DEAOMP) and N-(N,N-diethylacetamidino)-O-ethylfluorophosphate (DEAOEP) and the improvement of the qualification of the Chemical Analytical Control Laboratory experts taking part in the OPCW Proficiency Tests. Materials and methods. The technique of high efficient liquid chromatography coupled with tandem high resolution mass spectrometry (LC-MS/HRMS) was used during the investigation. The results. The results of optimization of conditions of mass-spectrometric detection, selection of optimal pairs of ion reactions and program of gradient elution during separation of chemicals in reversed-phase liquid chromatography were presented. Presented approach was tested in analysis of model aqueous samples; metrological parameters of detection of compounds were estimated. Conclusion. It was shown during investigation that electrospray ionization mass-spectra of DEAMP, DEAOMP and DEAOEP contain intensive peaks of protonated molecular ions, which after further fragmentation produce characteristic product-ions used for identification and high sensitive detection of parent compounds by LC-MS/HRMS. Limits of detection of DEAMP, DEAOMP and DEAOEP were 1.0 ng/mL, 0.5 ng/mL and 0.5 ng/mL, respectively