bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case management for acquired brain injury: A systematic review of the evidence base.
Authors: Leonard Rachel , Linden Mark , Holloway Mark 
Published: December 2023

Abstract

Background
Brain Injury Case management involves coordinating and organising services and systems around brain injured clients and their families. Case managers may come from diverse professional backgrounds but have expert understanding of the unique and often complex needs of people with acquired brain injury. In what is the largest review on this topic to date, we sought to explore the international evidence base in relation to case managers and acquired brain injury.
Methods
Searches were conducted with seven databases, using a search strategy based on key terms relating to “case management” and “brain injury”. Eligible studies included peer reviewed publications, with books and magazine pieces excluded. All studies were screened and independently extracted by two reviewers. The quality of empirical studies was assessed by the Mixed Methods Assessment Tool (MMAT), with the appropriate Joanna Briggs Institute (JBI) checklists used for systematic reviews and text and opinion studies. Given the diversity of the evidence reviewed, findings were presented narratively.
Results
Electronic searches identified 2,062 studies, of which 35 were deemed eligible to be included in this review. Of these, 3 were reviews, 12 were opinion pieces, and 20 were empirical research studies. The majority came from the USA (n = 15) and the UK (n = 10), with other studies originating from Australia (n = 8) and Canada (n = 2). Narrative synthesis of included studies highlighted the challenges of measuring and evaluating the impact of case management for brain injury, vital aspects of case management, such as good communication and relationships with clients, supporting the wider family, and expertise relating to brain injury. Findings also indicated that case managers must work across the continuum of care, working with their clients’ long term, possibly across acute, to post-acute and into community services.
Conclusions
The relative infancy of the case management profession creates certain challenges, however it also provides an ideal opportunity to shape its future in a way that is beneficial for the client, family and healthcare providers. Case managers have already made significant developments to the profession since its conception, however, future progression requires collaboration between academics, clinicians and case managers, to produce better outcomes for clients and their families.
[18F]FDG PET radiomics score generated by cross-combination approach for treatment response and prognosis prediction in primary gastrointestinal diffuse large B-cell lymphoma patients
Authors: Zhao Jincheng , Rong Jian , Teng Yue , Chen Man , Jiang Chong , Chen Jianxin , Xu Jingyan 
Published: December 2023

Abstract

Objectives
We investigated the value of using a machine learning cross-combination approach to construct a PET radiomics score (RadScore) for predicting the early treatment response and prognosis of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) treated with the R-CHOP-like regimen.
Methods
We conducted a retrospective analysis on 108 PGI-DLBCL patients diagnosed between November 2016 and December 2021. Seven machine learning models were used to generate 49 feature selection-classification candidates, and the optimal candidate was selected to create RadScore. Logistic regression identified risk factors, and a radiomics nomogram combining RadScore with selected risk factors was constructed. The model was evaluated using calibration curves and decision curve analysis (DCA).
Results
A total of 111 radiomics features were extracted, and 19 features with strong predictive performance were used to generate RadScore. Logistic regression analysis in the training cohort identified elevated lactate dehydrogenase (LDH) level, intestinal involvement, and total lesion glycolysis (TLG) as independent risk factors for predicting early treatment response. The multi-parameter model incorporating RadScore, clinical risk factors, and metabolic factors showed good performance (training cohort AUC: 0.860; validation cohort AUC: 0.902). The RadScore is capable of effectively stratifying patients' progression-free survival (PFS) and overall survival (OS).
Conclusions
The machine learning-based RadScore can predict the survival of PGI-DLBCL patients. When combined with clinical risk factors and metabolic factors, it forms a combinatorial model suitable for predicting early treatment response to R-CHOP-like chemotherapy regimens.
Autologous Rib Grafts for Craniocervical junction Surgery in Children: A Clinical Application
Authors: Deng Chenfu , Zou Xiaobao , Yang Haozhi , Fu Suochao , Chen Junlin , Ma Rencai , Xia Hong , Ma Xiangyang 
Published: December 2023

Abstract
Objective
Autologous iliac bone is commonly used as a bone graft material to achieve solid fusion in craniocervical junction (CVJ) surgery. However, the developing iliac bone of children is less than ideal as a bone graft material. The matured rib bone of children presents a potential substitute material for iliac bone. The aim of this study was to evaluate the efficacy of autologous rib grafts for craniocervical junction surgery in children.
Methods
The outcomes of 10 children with abnormalities of the craniocervical junction who underwent craniocervical junction surgery between January 2020 and December 2022 were retrospectively reviewed. All patients underwent posterior fusion and internal fixation surgery with autologous rib grafts. Pre- and post-operative images were obtained and clinical follow-ups were conducted to evaluate neurological function, pain level, donor site complications, and bone fusion rates.
Results
All surgeries were successful. During the 8- to 24-month follow-up period, all patients achieved satisfactory clinical results. Computed tomography at 3–6 months confirmed successful bone fusion and regeneration of the rib defect in all patients with no neurological or donor site complications.
Conclusion
Autologous rib bone is a safe and effective material for bone grafting in craniocervical junction fusion surgery for children that can reduce the risks of donor site complications and increase the amount of bone graft, thereby achieving a higher bone fusion rate.
Long-term results and quality of life after stapled hemorrhoidopexy vs Doppler-guided HAL-RAR: a propensity score matching analysis
Authors: Lauricella Sara , Palmisano Dario , Brucchi Francesco , Agoglitta Domenico , Fiume Massimiliano , Bottero Luca , Faillace Giuseppe 
Published: December 2023

Abstract
Aim
The study aimed to evaluate and compare the short and long-term outcomes of doppler-guided (DG) hemorrhoidal artery ligation and rectoanal repair (HAL-RAR) using a wireless-doppler guided probe (HALO™ Trilogy) and stapled hemorrhoidopexy (SH) for treatment of II-III hemorrhoids.
Methods
This cohort study included patients who underwent HAL-RAR (n = 89) or SH (n = 174) for grade II-III hemorrhoids between January 2020 and December 2021. After propensity score matching at a 1:1 ratio, 76 patients for each group were analyzed. Short and long-term outcomes were collected. Pain was measured using a Visual Analogue Scale (VAS) at POD1, POD 10, 1 month, and 6 months after surgery. The enrolled patients completed the Hemorrhoidal Disease Symptom Score Quality of Life (HDSS/SHS QoL) Quality of Life QoL questionnaire preoperatively and during a regular follow-up visit at 24 months after surgery.
Results
Groups exhibited comparable overall postoperative complication rates (15.7% HAL-RAR/ 17.1% SH; p = 0.3843). Postoperative pain via VAS showed median scores of 4, 3, 1, 1 for HAL-RAR and 6, 4, 2, 1 for SH at POD1, POD10, 1-month, and 6-months, respectively. At a median follow-up of 12 months, the recurrence rate was 10.5% in the HAL-RAR group and 9.2% in the SH group (p = 0.778801), respectively. At 24 months, 15.7% of HAL-RAR patients and 19.7% of SH patients remained symptomatic (p = 0.22313). Median post-op QoL index was 1 (HAL-RAR) and 0.92 (SH), p = 0.0365.
Conclusions
HAL-RAR is a safe and feasible technique in treating grade II-III hemorrhoids showing better outcomes in terms of postoperative pain and QoL.
Significance: This paper adds a new perspective in comparing the HAL-RAR and SH, focusing the attention on the patients and not surgical tecniques. A long and difficult follow-up was completed to fully understand the long-term results and the impact on the QoL of the patients that underwent these procedures.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell
Authors: Zhang Feifan , Hao Yang , Yang Ning , Liu Man , Luo Yage , Zhang Ying , Zhou Jian , Liu Hongjian , Li Jitian 
Published: December 2023

Abstract
Background Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With no significant advances in the treatment of OS in recent ten years, discovering new and effective anti-OS drugs became our top priority. Oridonin has been proved to mediate anti-tumor impact on OS cells, although it’s mechanism of action has not been fully understood.Methods Here, we investigated the inhibitory effect of oridonin on OS cells and its underlying mechanisms. In 143B and U2OS cells, oridonin’s pro-apoptosis and pro-ferroptosis effects on cell death, cell proliferation, cell migration, iron accumulation, mitochondrial membrane potential and lipid peroxidation production were observed. Western blot (WB) and real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) were used to detect the expression levels of apoptosis and ferroptosis-relative proteins and genes. Iron assay Kit was used to evaluate the relative Fe2+ content. The mitochondrial membrane potential detection kit and ROS assay kit were used to evaluate the levels of mitochondrial membrane potential and lipid peroxidation production. The changes of oridonin’s inhibitory on malignant phenotype of OS cells were examined after treating OS cells with the ferroptosis inhibitor ferrostatin-1 (Fer-1).Results Oridonin potently inhibited OS cells viability and metastasis. Simultaneously, oridonin suppressed the expressions of BAX, cl-caspase3, SLC7A11, GPX4 and FTH1 proteins and mRNA, while promoting the expressions of Bcl-2 and ACSL4 in 143 and U2OS cells. Furthermore, we found that oridonin also boosted the accumulation of reactive oxygen species (ROS), encouraged the buildup of Fe2+, and decreased the mitochondrial membrane potential in OS cells, but this effect can be reversed by Fer-1.Conclusion Oridonin can trigger apoptosis and ferroptosis collaboratively in OS cells, making it a promising and effective agent for OS therapy.
A Study of Livelihood Transformation Strategies for Digitally Driven Pastoralists’ Ecological Perceptions
Authors: lanlan Zhao , yong Xia , Xiandong Li 
Published: December 2023

Abstract

Digital information technology is progressively emerging as a key conduit for enhancing cognition, awakening, and fostering the transformation of herders’ subsistence practices. The digital countryside is a strategic avenue for rural rejuvenation. The essay examines the mediating role of grassland ecological cognition and uses 383 field research data from grassland pastoral areas in the northern frontier to analyze the influence of ICT embedding intensity on herders’ livelihood strategies using the Mlogit model. The research findings indicated that: (1) the northern herders’ primary livelihood choices were part-time and animal husbandry, which accounted for 52% of the total; on the other hand, the lowest proportion of work was done outside of their hometowns; and (2) there was a non-linear, inverted U-shaped relationship between the herders' livelihood strategies and ICT embeddedness. In other words, relative to the pure animal husbandry livelihood strategy, the deeper the ICT embedding intensity, the greater the probability of herders choosing the animal husbandry and part-time livelihood strategy, part-time livelihood strategy of animal husbandry and tourism, and work away from hometown livelihood strategy, but when the embedding intensity reaches the relative threshold, it will be unfavorable to the transformation of herders’ livelihoods. Therefore, herders should reasonably control the intensity of daily Internet access; (3) Herders’ ecological cognition can be greatly enhanced by ICT embedding, and herders’ online education and social interaction can also greatly enhance their ecological cognition; additionally, ecological cognition can act as a partial mediating factor between ICT embedding and the transformation of herders’ livelihood; (4) The analysis of heterogeneity indicates that it is advisable to limit the daily Internet access of herders to a range of 3–6 hours. This limitation has a positive impact on the transformation of herders’ livelihoods. Furthermore, within this range, a higher level of ICT embedding has a greater potential to promote the transformation of herders’ livelihoods, particularly among those in the middle and lower age groups.
Synthesis and Application of a New Polymeric Surfactant for Improving Oil Recovery: Interfacial Tension, Wettability and Viscosity Studies in Different Salinities
Authors: Golab Elias Ghaleh , Parvaneh Ronak , riahi siavash , Vatankhah-Varnosfaderani Mohammad , Nakhaee Ali 
Published: December 2023

Abstract

With the decline of conventional hydrocarbon reserves, polymers are widely used in various enhanced oil recovery (EOR) methods like surfactant-polymer (SP) flooding and alkaline-surfactant-polymer (ASP) flooding. The SP flooding method has a very complex formulation and design, and due to improper mixing, there may be undesirable phase separation. Recently, interesting work has been reported on synthesizing polymeric surfactants for use in EOR. Polymeric surfactants, as new compounds, are an attractive alternative to SP flooding because polymeric surfactants in which hydrophobic groups are attached to hydrophilic polymers play a dual role in improving the mobility ratio and reducing interfacial tension (IFT). The present paper deals with the rheological and synthesis properties of a new polymeric surfactant produced by bond co-polymerization reaction using different ratios of hydrolyzed polyacrylamide (HPAM) and a zwitterion hydrophobic group. Synthesized Hydrophobically Modified Zwitterionic Polyacrylamide (HMZPAM) was characterized by FTIR and HMNR analysis. The performance of polyacrylamide and HMZPAM were compared and the results show that HMZPAM was more and more suitable for EOR. HMZPAM was much better in IFT, Viscosity, Wettability, Oil recovery, and resistance to the different one and two valence cations. Our results show that while HPAM reduced the IFT to 13.65, HMZPAM reduced the IFT to 0.441 mN/m. The contact angle of the oil-wet rock sample changed to 62.76 (water-wet) and 21.23 degrees (strongly water-wet) using HPAM and HMZPAM, respectively. In salinity of 10,000 mg/l, the viscosity of HPAM and HMZPAM were measured as 62 cp and 174 cp, and at the shear rate of 400 S− 1, the viscosity of HPAM and HMZPAM was equal to 0.14 cp and 1.06 cp, respectively. HMZPAM also showed better properties in elevated salt concentrations. Core flooding tests showed that HMZPAM yields have better additional recovery due to the microscopic displacement than HPAM, with a total oil recovery of 84% compared to 48%.
Incorporation of RCM-simulated spatial details into climate change projections derived from global climate models
Authors: Ruosteenoja Kimmo , Räisänen Jouni 
Published: December 2023

Abstract

Regional climate models (RCMs) exhibit greater potential than global models (GCMs) in capturing geographical details of climate change arising from orography and land-water distribution, but dynamical downscalings are only available for a limited number of GCMs. The full GCM ensembles are much more representative. Furthermore, the current EURO-CORDEX RCM runs most likely underestimate future warming. Thus, neither GCMs nor RCMs as such constitute an ideal tool for preparing reliable spatially detailed climate projections.
This study introduces an easy-to-use GCM-RCM hybrid method that takes advantage of the best properties of both model categories. The large-scale response is adopted from GCM simulations, but the pattern is enriched with RCM-simulated details. For temperature projections, the procedure resembles the conventional pattern-scaling technique, but spatial averages of temperature change used for scaling are calculated over an area surrounding each grid point. For precipitation, a linearised version of the method has been formulated.
The applicability of the method is studied by integrating spatial details from 12 EURO-CORDEX RCM simulations with the CMIP6 multi-GCM mean projection. The resulting temperature responses include RCM-generated spatial details of up to ~1°C while effectively correcting the general tendency of RCMs to underestimate warming in Europe. The impact of the RCMs is most significant in summer. For precipitation, geographical details originating from the different CORDEX runs tend to diverge, leading to a low signal-to-noise ratio. This drawback is not due to the hybrid method but the substantial impact of internal variability on small-scale precipitation changes.
Functional Diversifications of Contact Calls in a Multi-level Primate Society
Authors: Yang Yi-Jun , Ying Yan , Tian Wen-Yong , Zhu Dai-Bo , Li Bao-Guo , Qi Xiao-guang 
Published: December 2023

Abstract
The ability to cultivate social relationships through language is human uniqueness. However, despite small repertoire sizes, nonhuman primates could use vocalization for social purposes too. Vocal communication could be evolutionarily ancient, and likely evolved hand-in-hand with complex, dynamic social structures. By studying the vocal communication in wild golden snub-nosed monkeys (Rhinopithecus roxellana), a species of Asian colobine living in 4-layer multi-level societies with fission-fusion dynamics, we unraveled the complex social functions of contact ‘coo’ calls. Contact calls helped cultivate both within- and between-unit relationships, and depending on the sexes, reproductive states, and social roles of callers and recipients, were also functionally diverse. Within units, calls replaced grooming and were supplementary to social proximity. Males directed more calls to lactating females, who were unavailable for grooming and away from unit centers due to extended foraging and childcare. Higher-ranking males called more frequently but did not receive more calls than lower-ranking ones. Considering their larger social network sizes and leadership roles, contact calls likely facilitated inter-unit proximity and were used for advertising intrasexual affiliation and alliances. By comparing the network of contact call exchange with that of social proximity and grooming, we identified the inter-unit social relationships that were otherwise inconspicuous and, more importantly, the potential mechanisms for maintaining male-male alliances and unit and band cohesion. Together with previous findings, we conclude that contact calls are economical and low-risk social tools for reassuring and advertising affiliation, resolving uncertainties, and promoting cohesion and alliance formation.
Factors associated with increased knowledge about breast density in women undergoing breast cancer screening
Authors: Bhattacharjee Avisak , Walsh David , Dasari Pallave , Hodson Leigh J. , Edwards Suzanne , White Sarah J. , Turnbull Deborah , Ingman Wendy V. 
Published: December 2023

Abstract

Purpose
Breast density is an independent risk factor for breast cancer and can impede detection of cancer by mammography. There is growing awareness of breast density in women attending breast cancer screening, however it is unclear whether this awareness is associated with increased knowledge. This study aims to evaluate breast density knowledge among Australian women attending breast cancer screening.
Method
This cross-sectional study was conducted among women undergoing breast cancer screening at The Queen Elizabeth Hospital Breast/Endocrine outpatient department. Participants were provided with a questionnaire to assess knowledge, awareness and desire to know their own breast density.
Result
A consecutive sample of 427 women were invited, and 350 women responded (response rate 82%). Overall, 61% had heard the term ‘breast density’ before and 57% answered at least two of five questions about breast density correctly. Prior breast density notification (OR = 3.59, 95%CI = 2.03, 6.36; p < 0.001), breast density awareness (OR = 2.68, 95%CI = 1.72, 4.18; p < 0.001), younger age (OR = 0.96, 95% CI = 0.95, 0.98; p < 0.001), and English as the language spoken at home (OR = 2.93, 95%CI = 1.14, 7.54; p = 0.03) were independent predictors of ‘some knowledge’ of breast density. A significant proportion of participants (82%) expressed desire to ascertain their individual breast density.
Conclusion
While knowledge of breast density in this Australian cohort is generally quite low, we have identified factors associated with increased knowledge. Given that the majority of participants expressed the desire to know individual breast density, further studies are warranted to determine the optimal interventions to increase breast density knowledge.
Meta-analysis of the effects of lifestyle interventions during pregnancy to prevent hypertensive disorders of pregnancy
Authors: Huang Lihua , Zhai Jinguo , Kong Ganxia , Wang xueyan , Chen Lijin , Yuan Xinyuan , Geng Xinqian , Chen Zhaotong , Liu Xuantian 
Published: December 2023

Abstract
Objective To investigate the preventive effect of lifestyle interventions during pregnancy on hypertensive disorders of pregnancy.
Methods By searching in Cochrane Library, PubMed, Web of Science, Embase, CINAHL, Chinese Biomedical Literature Database, Chinese Academic Journals Full Text Database, Wanfang Database Knowledge Service Platform and Vipshop Resource Master Database, we collected randomized controlled trials (RCTs) related to the effects of lifestyle interventions during pregnancy on hypertensive disorders of pregnancy and related maternal and infant outcomes . The search time frame was from database creation to 03/31/2023. Two investigators independently screened the literature, extracted materials, and evaluated the risk of bias of included studies before analysis using RevMan 5.4 software.
Results A total of 31 RCTs include 12737 study subjects . Meta-analysis results showed that compared with controls, lifestyle interventions during pregnancy were effective in preventing hypertensive disorders of pregnancy [RR=0.69, 95% CI (0.57, 0.85), P=0.0004], gestational hypertension [RR=0.63, 95% CI (0.45, 0.88), P=0.007], and preeclampsia [RR=0.81, 95% CI (0.66, 0.99), P=0.04]. The incidence of gestational diabetes mellitus, caesarean scar, total gestational weight gain, macrosomia, and neonatal weight were lower in the lifestyle intervention group than in the control group; however, there was no statistically significant difference between the two groups in terms of gestational week of delivery and preterm infant incidence (P>0.05).
Conclusion Lifestyle interventions during pregnancy can effectively prevent the occurrence of gestational hypertension and gestational diabetes mellitus, reduce the incidence of caesarean scar and macrosomia, and reduce neonatal weight and total gestational weight gain; however, the difference in gestational week of delivery and the incidence of preterm infant between the two groups was not statistically significant, and more high-quality original studies are still needed to further validate the findings.