bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decidual Macrophages Are the Population of Decidual Adherent Cells Which Regulates Perforin Expression in Cytolytic Cells
Authors: Sotošek V. , Laškarin G. , Strbo N. , Dohr G. , Blaschitz A. , Podack E.R. , Rukavina D. 
Published: October 2023

PROBLEM: We have shown that addition of decidual adherent cells (DAC) to the culture of decidual lymphocytes (DL) prevents the downregulation of perforin expression in these cells. Because DAC are a mixture of various cell populations, the aim is to analyze immunophenotypic characteristics of DAC and to determine which cell population is involved in the regulation of perforin expression.METHOD OF STUDY: First trimester pregnancy decidual cells were obtained by enzymatic tissue digestion. Decidual cells and peripheral blood lymphocytes (PBL) were centrifuged on Ficoll‐Hypaque density gradient and cultured overnight to obtain adherent cells, which were analyzed by flow cytometry and immunocytochemically.RESULTS: Almost all peripheral blood adherent cells (PBAC) (ca 90%) expressed monocyte/macrophage markers but only 10–20% of DAC. The rest of DAC expressed markers of stromal cells. HLA‐DR depleted population of DAC (stromal cells only) could not prevent downregulation of perforin expression in cultured DL and PBL.CONCLUSION: Decidual macrophages are involved in the regulation of perforin expression in DL.
Geometry of Hermitian symmetric spaces under the action of a maximal unipotent group
Authors: Geatti Laura , Iannuzzi Andrea 
Published: October 2023

Let [Formula: see text] be a non-compact irreducible Hermitian symmetric space of rank [Formula: see text] and let [Formula: see text] be an Iwasawa decomposition of [Formula: see text]. The group [Formula: see text] acts on [Formula: see text] by biholomorphisms and the real [Formula: see text]-dimensional submanifold [Formula: see text] intersects every [Formula: see text]-orbit transversally in a single point. Moreover [Formula: see text] is contained in a complex [Formula: see text]-dimensional submanifold of [Formula: see text] biholomorphic to [Formula: see text], the product of [Formula: see text] copies of the upper half-plane in [Formula: see text]. This fact leads to a one-to-one correspondence between [Formula: see text]-invariant domains in [Formula: see text] and tube domains in [Formula: see text]. In this setting we prove an analogue of Bochner’s tube theorem. Namely, an [Formula: see text]-invariant domain [Formula: see text] in [Formula: see text] is Stein if and only if the base [Formula: see text] of the associated tube domain is convex and “cone invariant”. We also prove the univalence of [Formula: see text]-invariant holomorphically separable Riemann domains over [Formula: see text]. This yields a precise description of the envelope of holomorphy of an arbitrary [Formula: see text]-invariant domain in [Formula: see text]. Finally, we obtain a characterization of several classes of [Formula: see text]-invariant plurisubharmonic functions on [Formula: see text] in terms of the corresponding classes of convex functions on [Formula: see text]. As an application we present an explicit Lie group theoretical description of all [Formula: see text]-invariant potentials of the Killing metric on [Formula: see text] and of the associated moment maps.
Dynamical Behavior of Two Coupled Two-Stroke Relaxation Oscillators
Authors: Ducci Daniele , Meucci Riccardo , Euzzor Stefano , Ginoux Jean-Marc , Di Garbo Angelo 
Published: October 2023

Starting from [J.-M. Ginoux et al., Torus breakdown in a uni junction memristor, Int. J. Bifurcation Chaos 28(10) (2018) 1850128; J.-M. Ginoux et al., Torus breakdown in a two-stroke relaxation memristor, Chaos Solitons Fractals 153 (2021) 111594], we define a model which describes the dynamical behavior of a class of two-stroke oscillators (i.e., nonlinear oscillators with two distinct phases per cycle). We highlight some properties of the model still not taken into account, like presence of a global bifurcation and bistability for some regions of the parameters space. We then extend the model to study two coupled two-stroke oscillators, where synchrony and anti-synchrony regimes appear as well as transient chaos and intermittency phenomena. We finally compare the theoretical results on synchrony regimes with the corresponding experimental data obtained from a circuit where two relaxation oscillators, based on the Unijunction Transistor (UJT) electronic component, are coupled together. The comparison shows a good qualitative agreement between the experiments and the theoretical results.
ERP Systems in Humanitarian and Private Sectors’ Supply Chains: Challenges and Success Factors
Authors: Lukyanova Iryna , Haddud Abubaker , Khare Anshuman 
Published: October 2023

Purpose: This paper investigates and compares challenges and success factors within different supply chain ERPs used globally across humanitarian and private organizations in Africa, Asia, Canada, Australia, Europe, and the Americas. Eighteen challenges and 27 success factors were selected from literature published between 2015 and 2020 to determine whether they are equally relevant globally in the private and humanitarian sectors. Design/methodology/approach: The research utilized an anonymous online questionnaire advertised on different social media websites and completed by 50 humanitarian supply chain professionals and 53 private sector professionals worldwide. The collected data was analyzed using a descriptive statistic–crosstabulation analysis to show the differences or similarities in supply chain professionals’ opinions from humanitarian and private organizations. Additionally, the hypotheses were tested by using the Mann–Whitney Test. Findings: Findings revealed that all the examined success factors were supported except one, which was similar in both sectors. However, the challenges during the implementation of ERPs differ in these two sectors — with four success factors not supported in the humanitarian sector and nine not supported challenges in the private sector. Originality: This study’s significance is that, as per the researchers’ knowledge, such a comparative study was never done before, and it will allow both sectors’ professionals to understand all the elements mentioned above better and integrate them while implementing supply chain ERPs.
Product of generalized derivations with Engel condition on Lie ideals in prime rings
Authors: Dhara Basudeb , Kar Sukhendu , Singh Kalyan 
Published: October 2023

This paper represents the structures of generalized derivations satisfying an identity with [Formula: see text]-Engel condition. To prove our result, we take [Formula: see text] as a prime ring with [Formula: see text], and [Formula: see text] as Utumi quotient ring of [Formula: see text]. The center of [Formula: see text] is [Formula: see text] which is called extended centroid of [Formula: see text]. Let [Formula: see text] be a non-central Lie ideal of [Formula: see text]. Suppose that [Formula: see text] and [Formula: see text] are two nonzero generalized derivations of [Formula: see text] and [Formula: see text], any fixed integer. If [Formula: see text] for all [Formula: see text], then one of the below-mentioned conclusions holds: (1) [Formula: see text] and [Formula: see text] for all [Formula: see text] and for some [Formula: see text] with [Formula: see text]; (2) [Formula: see text] satisfies [Formula: see text].
Computational Screening of Potential Fatty Acid Synthase Inhibitors as Broad-Spectrum Antiviral Agents
Authors: Xu Shaohua , Yuan Huicheng , Li Ling , Yang Kai , Zhao Liangcun 
Published: October 2023

Infectious diseases caused by viruses are one of the major diseases that seriously endanger global health. The development of broad-spectrum antiviral drugs for effective control of emerging and recurrent viral infectious diseases is urgently needed. Fatty acid synthase (FAS) has been reported as a valuable target for developing broad-spectrum antiviral drugs. In this study, we aimed to screen potent FAS inhibitors as broad-spectrum antiviral agents through computational approach. A pharmacophore model was generated with crystal structure of FAS in complex with Orlistat using Pharmit server, and 2,215 compounds were screened from ZINC15 database against the pharmacophore model. Next, 12 compounds exhibited more affinity to FAS than the control compound (Orlistat) were screened using molecular docking. The top three compounds (ZINC6146291, ZINC8925941 and ZINC3257427), which showed docking affinity to FAS with −8.19 kcal/mol, −8.14 kcal/mol and −8.07 kcal/mol, respectively, were subjected to 200 ns molecular dynamics simulation to evaluate the stability of docked complexes and their interaction mechanisms. The simulation trajectory analysis showed the stable conformation observed in FAS bound of the compounds and the screened compounds were firmly bound of the active sites of FAS throughout molecular dynamics simulation. The screened FAS candidate inhibitors can be used as broad-spectrum antiviral agents for in vitro-in vivo evaluations.
The First Public Murder in the Tanzimat Era: Life, Trial and Execution of Emine Hanım
Authors: Şiviloğlu Murat R. 
Published: October 2023

Abstract
In 1860, Emine Hanım killed her husband Ferik İbrahim Pasha. In this article, I use her murder trial to examine the interrelation between slavery, the private lives of the Ottoman ruling class, and the complexities of the judicial system during the Tanzimat period (1839–1876). I identify the limitations of nineteenth-century legal reforms and the discrepancy between the reformist ideals and the real-world complexities experienced by individuals. By paying close attention to legal issues in the Ottoman Empire during the Tanzimat era, such as siyaseten katl (administrative death penalty) and the inconsistent application of kısas (retaliation in kind), I argue that Emine’s story contributes to a better understanding of the Ottoman legal system during the reform era.
Teaching of silver diamine fluoride for the management of dental caries and hypersensitivity – situation in the Southeast Asia dental schools
Authors: He Shuyang , Wu Sicheng , Duangthip Duangporn , Chu Chun Hung , Lo Edward Chin Man 
Published: October 2023

Abstract
Background
Using silver diamine fluoride (SDF) for caries management has raised dentists’ interests in Southeast Asia (SEA). However, information about the teaching of SDF in dental schools in SEA is limited. Therefore, this survey aimed to describe the extent to which SDF had been introduced into the education of undergraduate students in the dental schools in SEA.

Methods
An online questionnaire survey was conducted on the duration, method, contents, and barriers regarding the teaching of SDF. Teachers in charge of undergraduate program in pediatric dentistry and those in community dentistry in all the 90 dental schools in SEA were approached and we required each department to reply once only. Descriptive statistics and Chi-square test were used to describe and assess the differences between the two departments in the teaching of SDF.

Results
A total of 81 responses from the departments of 49 schools were received, giving a school-level response rate of 54% (49/90). SDF was taught in the undergraduate program in 86% (42/49) of the respondent schools, and 50% (21/42) of these schools had included SDF in the teaching for five or more years. Almost all (98%) of the departments taught SDF through lectures. Furthermore, 55% of them adopted SDF in clinical practice. Regarding the teaching content, the use of SDF for arresting cavitated caries lesion was the most commonly covered (82–97%), followed by for arresting early noncavitated lesions (69–82%), for preventing new caries development (66–79%) and for treating dental hypersensitivity (77%). There were variations in the post-treatment instruction taught. For the departments not teaching SDF, the most common reason (10/19, 53%) was that SDF was not available.

Conclusion
SDF is covered in the undergraduate program in most of the dental schools in SEA. The use of SDF to arrest cavitated caries lesions in primary teeth is usually taught. However, other applications of SDF, such as for prevention of caries and treatment of dental hypersensitivity, are less commonly mentioned in the teaching.
Antibiotic prescription in bone augmentation and dental implant procedures: a multi-center study
Authors: Bazsefidpay Nikoo , Holmqvist Fredrik , Khalil Dalia , Wexell Cecilia Larsson , Hultin Margareta , Nilsson Peter , Lund Bodil 
Published: October 2023

Abstract
Background
Adherence to antibiotic recommendations and safety aspects of restrictive use are important components when combating antibiotic resistance. The primary aim of this study was to assess the impact of national guidelines on antibiotic prescriptions for bone augmentation procedures among dentists working at three specialized clinics. The secondary aim was to assess the occurrence of postoperative infections.

Methods
Medical charts of 400 patients treated with bone augmentation were reviewed: 200 in the years 2010–2011 and 200 in 2014–2015. The Swedish national recommendations for antibiotic prophylaxis were published in 2012.

Results
There was a wide variation in antibiotic regiments prescribed throughout the study. The number of patients treated with antibiotic prophylaxis in a single dose of 2 g amoxicillin, and treated as advocated in the national recommendations, was low and decreasing between the two time periods from 25% (n = 50/200) in 2010–2011 to 18.5% (n = 37/200) in 2014–2015. The number of patients not given any antibiotics either as a prophylactic single dose or during the postoperative phase increased (P < 0.001). The administration of a 3-7-days antibiotic prescription increased significantly from 25.5% in 2010–2011 to 35% in 2014–2015. The postoperative infection rates (4.5% and 6.5%) were without difference between the studied periods. Smoking and omitted antibiotic prophylaxis significantly increased the risk of postoperative infection. Logistic regression analyses showed that patient male gender and suffering from a disease were predictive factors for the clinician to adhere to the guidelines.

Conclusions
After introduction of national recommendations for antibiotic prophylaxis before bone augmentation procedures, the patient group receiving a single preoperative dose decreased while the group not given antibiotic prophylaxis increased. There was no difference in occurrence of postoperative infections between the two time periods. The results indicate a need for educational efforts and strategies for implementation of antibiotic prudence and awareness among surgeons performing bone augmentation procedures.
Effects of a physical exercise program on HIF-1α in people with Chronic Obstructive Pulmonary Disease living at high altitude: study protocol for a clinical trial
Authors: Villamil-Parra Wilder , Cristancho-Mejía Édgar , Ramon Torrella Joan , Mancera-Soto Erica Mabel 
Published: October 2023

Abstract
Background
Chronic Obstructive Pulmonary Disease (COPD) is a chronic, noncommunicable disease characterized by hypoxemia, with altered lung function, dyspnea on mild exertion, limited tolerance to physical exertion, and functional impairment. Physical exercise has been recommended worldwide as an efficient strategy to improve the autonomy and quality of life of patients affected by COPD. However, the adaptive molecular mechanisms occurring in these patients after the exposure to the hypoxic stimulus triggered by physical exercise have currently not been described in populations living at high altitude.

Methods
The clinical trial we are presenting here consists of a quasi-experimental design with longitudinal analysis of repeated measures, with intra- and inter-group comparisons, measuring primary and secondary variables in 4 temporal points. Participants will be people with a diagnosis of COPD residing at high altitudes (> 2600 m), without oncological, renal, cardiac, or musculoskeletal comorbidities with a low level of physical activity. The intervention will be an 8-week program of physical exercise of resistance and muscular strength (8-WVP) which will be carried out at home. Primary outcome variables will be the expression of HIF-1α, VEGF, and EPO. As secondary outcome variables, we will consider lung function (measured by spirometry), physical performance (measured by ergospirometry and dynamometry), and hematological parameters.

Discussion
The results obtained after the clinical trial proposed here will promote knowledge on the expression of signaling proteins as an adaptive response to hypoxia in people with COPD living at high altitude, which will be relevant because there are not data on this population group. The knowledge generated from the application of this protocol will increase the pathophysiological understanding of the disease and future medical and therapeutic decision-making based on physical exercise prescription.

Trial registration {2a}
NCT04955977 [ClinicalTrials.gov]—NCT04955977 [WHO ICRTP]. First Posted: July 9, 2021.
Engineering geological characteristics and failure mechanics of Jure rock avalanche, Nepal
Authors: Panthee Suman , Dulal Suman , Pandey Vishnu Himanshu Ratnam , Yadav Vikas , Singh Prakash Kumar , Kainthola Ashutosh 
Published: October 2023

Abstract
Introduction
The rock avalanches are a frequent and disruptive phenomenon in the Himalayas and other mountain chains. To minimize future losses, it is essential to investigate the engineering geological causative factors and mechanism of these mass wasting events.

Study area
The present work is aimed at assessing the failure mechanism of the disastrous 2014 Jure rock avalanche along Araniko Highway, Northern Nepal. The event had blocked the Sunkoshi River and blocked an economically significant route to China.

Geotechnical properties and analysis
Initially, rockmass characterization and intact strength attribute were determined for the site to classify the failure zone. The parameters measured and obtained from the field and laboratory were integrated into the analytical models to obtain a conclusive interpretation of the failure mechanism. Structural, kinematic, and key block theory analyses have been carried out for decipher the evolution of the failure zone.

Results and discussion
Rock mass was found to be of fair quality, however, the structural instabilities and the presence of water has led to a progressive failure. Movement of the key block and subsequent sliding of wedges and foot failure appears to be a possible failure mechanism.

Conclusion
The present research explores the contributory engineering geological aspects of the Jure rock avalanche. The investigation results can be used to tackle similar large scale rock avalanches in similar geological terrains and thus minimizing the losses.
Monetary policy transmission channels and the performance of the real sectors in selected sub-Saharan African countries: a system-GMM approach
Authors: Onaga Ifeoma Florence , Arize Augustine C. , Onwumere Josaphat U. J , Kalu Ebere Ume 
Published: October 2023

Abstract
This study investigated the impact of monetary policy channels on the real sector performance in selected sub-Saharan African countries. This study covers the period 1990 to 2020. The broad objective of the study was to examine the impact of monetary policy transmission channels on the real sectors of selected sub-Saharan African countries within the period, 1990–2020. Using the system generalized method of moments (sys-GMMs) amidst other pre-estimation and post-estimation tests, it was discovered that credit and exchange rate channels positively drove agricultural productivity, while interest rate channel exerted a negatively significant influence. Conversely, credit and exchange rate channels were found to negatively affect manufacturing, while interest rate channels had no significant impact on the manufacturing sector. Given the overwhelming impact of monetary policy channels on both the agricultural and manufacturing sectors of the SSA economies, it is recommended that effective monetary policy framework be put in place to continually create positive transmission effect on the real and productive sectors of the economy.
Seasonal diversity & spaciotemporal distribution of fungal endophytes associated with the medicinal plant Coleus forskohlii Briq.
Authors: Crasta Grace Leena , Koteshwar Anandrao Raveesha 
Published: October 2023

Fungi that colonize the healthy tissues of the plants without showing any disease symptoms in the host plants are termed as fungal endophytes. The presence of fungal endophytes provides a positive effect on the host’s growth & development and also triggers the production of some essential bioactive compounds in the host. This study was undertaken to isolate, identify and understand the spaciotemporal distribution and seasonal diversity of fungal endophytes associated with the leaf, stem & root of Coleus forskohlii, an important and endangered medicinal plant. Sampling was done for a period of 12 months between May 2020–April 2021. A total of 950 fungal endophytes were isolated from a total of 1680 tissues of the leaf, stem & root of C. forskohlii. The fungi were identified based on their morphological features and some of them were identified by molecular identification by 18S rRNA sequencing. The endophytic isolates belonged to 10 different orders belonging to 3 different classes-Sordariomycetes (Hypocreales, Xylariales, Microascales, Trichosphaeriales, Glomerellales & Sordariales), Dothiomycetes (Pleosporales, Capnodiales, Botryosphaeriales) & Eurotiomyctes (Eurotiales). About 81.26% of the isolates belonged to Ascomycota & 2.63% of the isolates belonged to Mucoromycota. Chaetomium globosum, Collariella bostrychodes, C. robusta, Colletotrichum gloeosporioides, Fusarium chlamydosporum, Sterile hyaline mycelia, Aspergillus niger, Xylaria curta, X. grammica, Mucor circinelloides & Trichoderma harizianum were the frequently isolated species of fungi. C. globosum, C. bostrychodes, C. gloeosporioides, sterile hyaline mycelia & X. curta were found distributed in all the tissues of the plant. C. forskohlii has thus revealed a rich diversity of fungal endophytes that could be isolated & cultured to yield some pharmacologically important bioactive compounds.