bluuebunny/crossref_metadata_2025_split huggingface dataset:
The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair
Authors: Morales-Ruiz T. , Beltrán-Melero C. , Ortega-Paredes D. , Luna-Morillo J. A. , Martínez-Macías M. I. , Roldán-Arjona T. , Ariza R. R. , Córdoba-Cañero D. 
Published: January 2024

AbstractBase excision repair (BER) generates gapped DNA intermediates containing a 5′-terminal 2-deoxyribose-5-phosphate (5′-dRP) group. In mammalian cells, gap filling and dRP removal are catalyzed by Pol β, which belongs to the X family of DNA polymerases. In higher plants, the only member of the X family of DNA polymerases is Pol λ. Although it is generally believed that plant Pol λ participates in BER, there is limited experimental evidence for this hypothesis. Here we have characterized the biochemical properties of Arabidopsis thaliana Pol λ (AtPol λ) in a BER context, using a variety of DNA repair intermediates. We have found that AtPol λ performs gap filling inserting the correct nucleotide, and that the rate of nucleotide incorporation is higher in substrates containing a C in the template strand. Gap filling catalyzed by AtPol λ is most efficient with a phosphate at the 5′-end of the gap and is not inhibited by the presence of a 5′-dRP mimic. We also show that AtPol λ possesses an intrinsic dRP lyase activity that is reduced by mutations at two lysine residues in its 8-kDa domain, one of which is present in Pol λ exclusively and not in any Pol β homolog. Importantly, we also found that the dRP lyase activity of AtPol λ allows efficient completion of uracil repair in a reconstituted short-patch BER reaction. These results suggest that AtPol λ plays an important role in plant BER.
Longitudinal patterns of scientific collaboration in doctoral studies
Authors: Cugmas Marjan , Mali Franc , Kronegger Luka 
Published: January 2024

AbstractDoctoral studies play a vital role in socializing young individuals in science as they navigate the challenges of modern knowledge-based societies. Taking various forms and intensities, the mentor–mentee relationship is integral to this process. The paper therefore addresses the temporal patterns of scientific collaboration between mentors and mentees, as well as among co-mentors, given that understanding the characteristics of mentoring collaborations is essential for developing successful higher education strategies for attracting potential doctoral students and designing effective science policies. Patterns of collaboration were identified using a symbolic data clustering approach and described using linear discriminant analysis. The data come from national information systems in Slovenia and cover the period between 1991 and 2020. On the mentor–mentee level, six types of scientific collaborations were identified and classified in three broader categories:study-limited,already established, andborn and raised. The most common,born and raised,is characterized by students who are isolated from the scientific community at the beginning of their studies and have become well integrated into the scientific community and highly productive researchers by the time they complete their doctoral studies. Thestudy-limitedcollaboration pattern is becoming increasingly popular and more common in the natural and technical sciences. Thealready establishedis more common among older mentees. The notion that mentoring promotes long-term scientific collaboration between mentors is not confirmed by the presented study. However, higher levels of collaboration between mentors are associated with younger age, working in the same scientific discipline, and younger mentors.
Universalism and particularism in the recommendations of the nobel prize for science
Authors: Ko Byoung-Kwon , Jang Yeongkyun , Yang Jae-Suk 
Published: January 2024

AbstractFrom the viewpoints of universalism and particularism, this paper investigates the process of recommendation by focusing on peer review for the Nobel Prize for Science from 1901 to 1970. The results indicate that self-recommendation practices are routine, especially in developed countries, and that the recommendation network is fundamentally built on mutually beneficial relationships between countries. The analysis also reveals that political, economic, military, biological, and colonial factors irrelevant to scientific performance impact the recommendations. During the study period, the Cold War evoked severe tensions between the Western and Eastern Blocs and influenced recommendations on each side; political and military factors also played a role. The main findings imply apparent evidence for particularism, indicating the presence of bias in the recommendation process. This paper provides suggestions for improvement of the selection process for the Nobel Committee.
A European Unemployment Benefit to Protect Atypical Workers?
Authors: Jara H. Xavier , Simon Agathe 
Published: January 2024

AbstractThis paper evaluates the potential of a common unemployment insurance scheme for the Economic and Monetary Union (EMU-UI) to improve income protection of atypical workers, namely those in part-time and temporary contracts. Our approach relies on simulating entitlements to national unemployment insurance and the EMU-UI to assess their effects on the household disposable income of atypical workers in the event of unemployment. Our results show that the introduction of an EMU-UI would reduce coverage gaps and increase net replacement rates, especially for atypical workers, and would protect a large share of the workforce against the risk of poverty. Extending eligibility for the EMU-UI to the self-employed would further improve income protection, reducing their risk of falling into poverty in the event of unemployment.
Job satisfaction, depression severity and quality of life ratings of perioperative nurses in robotic-assisted and laparoscopic surgery
Authors: Turgut Dilara Nur , Tuncel Ece , Palta Aslihan , Tektas Mehtap , Balci Melih , Guzel Ozer , Keten Tanju , Aslan Yilmaz , Tuncel Altug 
Published: January 2024

AbstractThe rapid introduction of technological developments into healthcare systems adds another layer of complexity to the already demanding jobs of nurses, particularly for those working in perioperative care. In the present study, our primary aim is job satisfaction, whereas the secondary outcomes are psychological well-being and quality of life (QoL) ratings of perioperative nurses who take part in robotic-assisted and pure laparoscopic surgery. A total of 101 perioperative nurses in six different centers were included in the study. Fifty-one of the nurses were working in robotic-assisted laparoscopic surgery and 50 of them were working in pure laparoscopic surgery. All participants responded to Minnesota Job Satisfaction Questionnaire (MJSQ), Beck Depression Inventory (BDI) and SF-36 QoL Measurement Survey. The two groups did not differ in their total MJSQ, BDI and SF-36 QoL scores (pMJSQ:0.066, pBDI:0.329, pSF-36-QoL:0.136). In addition, there were no differences between the two groups in their intrinsic job satisfaction and extrinsic job satisfaction sub-scores (pintrinsic: 0.473, pextrinsic:0.121). Overall, 18.9% of the nurses reported having moderate to extreme depressive symptoms and most of them (87.1%) had low to moderate levels of job satisfaction. Finally, QoL ratings was generally at moderate levels. Perioperative nurses who work in robotic-assisted laparoscopic surgery do not differ from those working in pure laparoscopic surgery in terms of their job satisfaction, psychological well-being, and QoL ratings. In addition, across groups’ psychological well-being, job satisfaction, and QoL ratings were not particularly high, suggesting that more attention needs to be paid to improving the work conditions of perioperative nurses.
Outcomes of lateral approach in robot-assisted radical prostatectomy: insights from a single-surgeon experience
Authors: Giulioni Carlo , Castellani Daniele , Vuong Nam-Son , Riviere Julien , Piechaud-Kressmann Julie , Lopez Laurent Hugo , Piechaud Thierry , Roche Jean-Baptiste , Rouffilange Jean , Hoepffner Jean-Luc , Galosi Andrea Benedetto , Gaston Richard Pierre , Pierquet Grégory 
Published: January 2024

AbstractIn the era of robotic prostate surgery, various techniques have been developed to improve functional outcomes. Urinary continence has shown satisfactory results, but the preservation of lateral nerves to the periprostatic capsule is only achievable by sparing the pubovesical complex. This study aims to present the first cases of lateral-approach robot-assisted radical prostatectomy (LRRP) performed by a novice surgeon. We conducted a retrospective analysis of 70 prostate cancer patients who underwent LRRP between October 2019 and September 2021, analyzing the perioperative and functional outcomes. The median operative time and intraoperative blood loss were 102 (92–108) minutes and 150 (130–180) mL, respectively. Five minor postoperative complications were reported, and the median hospital stay was 2 (1–2) days. Eleven positive surgical margins occurred. Potency and urinary continence recovery were achieved in 59 (84%) and 66 (94%) patients, respectively, 12 months after surgery. Our analysis shows that LRRP is a safe and effective procedure for prostate cancer surgery. Continence and potency recovery required a short learning curve, with an acceptable recovery rate even in the initial cases.
Microcapsule-enabled self-healing concrete: A bibliometric analysis
Authors: Zhou Shuai , Li Zijian , Li Kai , Jia Yue , Wang Chong , Zhuang Xiaoying 
Published: January 2024

AbstractWith the development of self-healing technology, the overall properties of the microcapsule-enabled self-healing concrete have taken a giant leap. In this research, a detailed assessment of current research on the microcapsule-enabled self-healing concrete is conducted, together with bibliometric analysis. In the bibliometric analysis, various indicators are considered. The current state of progress regarding self-healing concrete is assessed, and an analysis of the temporal distribution of documents, organizations and countries of literature is conducted. Later, a discussion of the citations is analyzed. The research summarizes the improvements of microcapsule-enabled self-healing cementitious composites and provides a concise background overview.
Tool-integrated thin-film sensor systems for measurement of cutting forces and temperatures during machining
Authors: Plogmeyer Marcel , González Germán , Pongratz Christina , Schott Anna , Schulze Volker , Bräuer Günter 
Published: January 2024

AbstractEffective in-process control mechanisms are vital for the future development of production processes and ask for reliable monitoring of process variables. For this, new tool-integrated sensor systems for measuring cutting forces and temperature for machining of hardened steel are proposed. Thin-film technology is used to apply a thermoresistive temperature sensor in the chip-workpiece contact area for the first time on industrial cutting inserts with chip breaker geometry. Complementary piezoresistive thin-film sensors based on diamond-like carbon (DLC) and manganin layers were developed and deposited on a washer. It was placed beneath the indexable insert to measure the cutting forces. Turning experiments were conducted to study sensor life and accuracy. All sensors showed an adequate lifetime for laboratory purposes. Temperature compensation methods were investigated for force measurement and results compared to forces recorded by a dynamometric platform. While temperature compensation for the DLC-based sensor needs further optimization, results of the manganin-based sensor compared well with the expected cutting forces. The manganin thin-film sensor exhibited rapid responsiveness and great reproducibility, underscoring its prospective utility for real-time monitoring of cutting forces in machining operations.
Towards a dynamic, comprehensive conceptualization of dyslexia
Authors: Wolf Maryanne , Gotlieb Rebecca J. M. , Kim Sohyun An , Pedroza Veronica , Rhinehart Laura V. , Tempini Maria Luisa Gorno , Sears Sue 
Published: January 2024

AbstractHere we build from the central strength of the existing definition of dyslexia—its emphasis on neurobiological origins—and proffer a set of seven core principles for a new, more comprehensive conceptualization of dyslexia. These principles derive from two major research directions: (1) the still evolving history of attempts to explain dyslexia, including in varied writing systems; and (2) the study of the reading brain circuit, its development, and its genetic and environmental influences. What emerges from connecting these two directions is a dynamic conceptualization of dyslexia that incorporates the extensive research on the heterogeneity of dyslexia and the interdependent contributions of multiple biological and socio-cultural risk and preventive factors. A new definition of dyslexia, therefore, needs to transcend both past unitary characterizations and past assumptions based largely on the English orthography. Such a conceptualization references the ways that different languages interact with the reading brain circuit to produce different sources of reading failure. Similarly, the characteristics and consequences of dyslexia that have been considered as secondary sequela (e.g., reduced reading comprehension, social-emotional issues) should be part of a more comprehensive narrative. Of critical importance, any definition of dyslexia should clarify persisting misconceptions that associate dyslexia with a lack of intelligence, potential to learn, or talents. Thus, the overall purpose of such a definition should serve as an instrument of knowledge and an enduring reason for pursuing growth in reading for the individual, the educator, and the public.
The Utility of AI in Writing a Scientific Review Article on the Impacts of COVID-19 on Musculoskeletal Health
Authors: Awosanya Olatundun D. , Harris Alexander , Creecy Amy , Qiao Xian , Toepp Angela J. , McCune Thomas , Kacena Melissa A. , Ozanne Marie V. 
Published: January 2024

Abstract
Purpose of Review
There were two primary purposes to our reviews. First, to provide an update to the scientific community about the impacts of COVID-19 on musculoskeletal health. Second, was to determine the value of using a large language model, ChatGPT 4.0, in the process of writing a scientific review article. To accomplish these objectives, we originally set out to write three review articles on the topic using different methods to produce the initial drafts of the review articles. The first review article was written in the traditional manner by humans, the second was to be written exclusively using ChatGPT (AI-only or AIO), and the third approach was to input the outline and references selected by humans from approach 1 into ChatGPT, using the AI to assist in completing the writing (AI-assisted or AIA). All review articles were extensively fact-checked and edited by all co-authors leading to the final drafts of the manuscripts, which were significantly different from the initial drafts.

Recent Findings
Unfortunately, during this process, it became clear that approach 2 was not feasible for a very recent topic like COVID-19 as at the time, ChatGPT 4.0 had a cutoff date of September 2021 and all articles published after this date had to be provided to ChatGPT, making approaches 2 and 3 virtually identical. Therefore, only two approaches and two review articles were written (human and AI-assisted). Here we found that the human-only approach took less time to complete than the AI-assisted approach. This was largely due to the number of hours required to fact-check and edit the AI-assisted manuscript. Of note, the AI-assisted approach resulted in inaccurate attributions of references (about 20%) and had a higher similarity index suggesting an increased risk of plagiarism.

Summary
The main aim of this project was to determine whether the use of AI could improve the process of writing a scientific review article. Based on our experience, with the current state of technology, it would not be advised to solely use AI to write a scientific review article, especially on a recent topic.
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Authors: Methi Aditi , Islam Md Rezaul , Kaurani Lalit , Sakib M Sadman , Krüger Dennis M. , Pena Tonatiuh , Burkhardt Susanne , Liebetanz David , Fischer André 
Published: January 2024

AbstractExercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline.
Suitability of the height above nearest drainage (HAND) model for flood inundation mapping in data-scarce regions: a comparative analysis with hydrodynamic models
Authors: Thalakkottukara Navin Tony , Thomas Jobin , Watkins Melanie K. , Holland Benjamin C. , Oommen Thomas , Grover Himanshu 
Published: January 2024

AbstractUnprecedented floods from extreme rainfall events worldwide emphasize the need for flood inundation mapping for floodplain management and risk reduction. Access to flood inundation maps and risk evaluation tools remains challenging in most parts of the world, particularly in rural regions, leading to decreased flood resilience. The use of hydraulic and hydrodynamic models in rural areas has been hindered by excessive data and computational requirements. In this study, we mapped the flood inundation in Huron Creek watershed, Michigan, USA for an extreme rainfall event (1000-year return period) that occurred in 2018 (Father’s Day Flood) using the Height Above Nearest Drainage (HAND) model and a synthetic rating curve developed from LIDAR DEM. We compared the flood inundation extent and depth modeled by the HAND with flood inundation characteristics predicted by two hydrodynamic models, viz., HEC-RAS 2D and SMS-SRH 2D. The flood discharge of the event was simulated using the HEC-HMS hydrologic model. Results suggest that, in different channel segments, the HAND model produces different degrees of concurrence in both flood inundation extent and depth when compared to the hydrodynamic models. The differences in flood inundation characteristics produced by the HAND model are primarily due to the uncertainties associated with optimal parameter estimation of the synthetic rating curve. Analyzing the differences between the HAND and hydrodynamic models also highlights the significance of terrain characteristics in model predictions. Based on the comparable predictive capability of the HAND model to map flood inundation areas during extreme rainfall events, we demonstrate the suitability of the HAND-based approach for mitigating flood risk in data-scarce, rural regions.
Detection of oxalyl-CoA decarboxylase (oxc) and formyl-CoA transferase (frc) genes in novel probiotic isolates capable of oxalate degradation in vitro
Authors: Youssef HebatAllah Ibrahim AbdElazeim 
Published: January 2024

AbstractOxalate degradation is one of lactic acid bacteria’s desirable activities. It is achieved by two enzymes, formyl coenzyme A transferase (frc) and oxalyl coenzyme A decarboxylase (oxc). The current study aimed to screen 15 locally isolated lactic acid bacteria to select those with the highest oxalate degradation ability. It also aimed to amplify the genes involved in degradation. MRS broth supplemented with 20 mM sodium oxalate was used to culture the tested isolates for 72 h. This was followed by an enzymatic assay to detect remaining oxalate. All isolates showed oxalate degradation activity to variable degrees. Five isolates demonstrated high oxalate degradation, 78 to 88%. To investigate the oxalate-degradation potential of the selected isolates, they have been further tested for the presence of genes that encode for enzymes involved in oxalate catabolism, formyl coenzyme A transferase (frc) and oxalyl coenzyme A decarboxylase (oxc). Three strains showed bands with the specific OXC and FRC forward and reverse primers designated as (SA-5, 9 and 37). Species-level identification revealed Loigolactobacillus bifermentans, Lacticaseibacillus paracasei, and Lactiplantibacillus plantarum. Preliminary results revealed that the tested probiotic strains harbored both oxc and frc whose products are putatively involved in oxalate catabolism. The probiotic potential of the selected strains was evaluated, and they showed high survival rates to both simulated gastric and intestinal fluids and variable degrees of antagonism against the tested Gram-positive and negative pathogens and were sensitive to clarithromycin but resistant to both metronidazole and ceftazidime. Finally, these strains could be exploited as an innovative approach to establish oxalate homeostasis in humans and prevent kidney stone formation.
Laparoscopic Posterior Partial Fundoplication Versus Total Fundoplication in Anti-reflux Surgery: A Comparative Study
Authors: Mohamed Ashraf Abdelazeem , Elian Mohammad Abdulraheem , Abdelzaher Mohamed Abdelaziz , Kamel Mohamed Khalafallah , Abdelaziz Asaad Abdelrahman 
Published: January 2024

AbstractThe aim of the present study was to evaluate advantages of partial posterior fundoplication (PPF) compared with traditional total fundoplication (TF). The study included 90 patients with GERD at El-Minia University Hospital between January 2019 and January 2023, divided randomly into group A: PPF (no. 45 patients) and group B: TF (no. 45 patients). All included patients had endoscopic hiatal hernia and various degrees of esophagitis. Postoperative follow-up included satisfaction questionnaire, degree of heartburn questionnaire, frequent belching, inability to belch, bloating, diarrhea, vomiting, abdominal pain, and endoscopic evaluations. Heartburn improved in all patients (p = 0.000). Shorter operative time was observed in group B (p = 0.007). There is no significant difference in overall satisfaction level between the two groups (p = 0.5). Surgical treatment is the favorite option for the treatment of GERD. PPF has the advantage of shorter operative time and can be safely used with outcomes similar to that of TF.