bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combating stigma: development and implementation of an education resource on older adults behavioral health challenges
Authors: Mackiewicz Marissa Katerina , Slattum Patricia , Waters Leland 
Published: October 2023

Purpose
This paper aims to describe the development, implementation and evolution of a multi-media educational tool to improve health profession students’ knowledge and awareness of stigma and ageism on the treatment of older adults with substance use disorder (SUD). In addition, this paper outlines the relationship between mental health and SUD and the impact of health provider stigmatization of older adults with behavioral health needs and the relationship between SUD and mental illness.

Design/methodology/approach
A literature review was conducted and initial project outlines was developed. Ten interviews were completed with content experts. The draft video was reviewed and minor revisions were incorporated. The facilitator guide accompanying the video was developed. A draft of the facilitator guide was shared with several interprofessional university faculty and the older adults with SUD. The video was presented to groups of health professions students, and following each video viewing, discussion content was used to provide additional edits.

Findings
The educational resources created for this project are appropriate for health professions curriculums related to older adults. Interprofessional health professions students are developing a basic foundation of knowledge on SUD through their standard coursework. More compassionate vocabulary is slowly being incorporated into health provider. Knowledge related to treatments and resources to treat SUD is lacking. In addition, health professions students need more education focused on assessment and interventions for individuals suspected of problematic substance use.

Originality/value
This paper fulfills an identified need to facilitate discussion and education around SUD for health professions students.
Educators’ roles and challenges in supporting tertiary education students’ mental health: a qualitative study in Malaysia
Authors: Soo Yue Yin , Wong Yuet Yen , Ong Siew Chin , Ooi Guat See 
Published: October 2023

Purpose
Educators play a vital role in supporting tertiary education students’ mental health, as they have frequent interactions with their students. However, information on the strategies and difficulties educators face in this area is scarce, particularly within the multi-ethnic Asian population. Therefore, this study aims to explore Malaysian educators’ roles and challenges in handling students with mental health issues.

Design/methodology/approach
Semi-structured interviews were conducted with a sample of 12 educators from tertiary education in Malaysia. All interviews were recorded, transcribed and analysed using thematic analysis.

Findings
Four themes were emerged: perceived factors contributing to mental health issues among students, educators’ strategies in supporting students’ mental health, difficulties in supporting students’ mental health and training to support students’ mental health.

Originality/value
To the best of the authors’ knowledge, this is the first study exploring the roles and challenges educators face in supporting tertiary education students’ mental health in Malaysia.
The impact of Industry 4.0 capabilities on operational performance: the mediating effect of supply chain ambidexterity
Authors: AL-Khatib Ayman wael 
Published: October 2023

PurposeThe current work sought to investigate the mediating effect of supply chain ambidexterity on the relationship between Industry 4.0 capabilities and operational performance of manufacturing firms in Jordan.Design/methodology/approachData collection was carried out through a survey with 253 respondents from manufacturing firms in Jordan through the first quarter in 2023. The quantitative approach and structural equation modeling (SEM) were applied to analyze the collected data. Dynamic capabilities view (DCV) theory was the adopted theoretical lens for this work.FindingsThe results demonstrated that Industry 4.0 capabilities positively and significantly affect exploration, exploitation and operational performance. In addition, the results confirmed that exploration and exploitation positively and significantly affect operational performance. Further, it is also found that exploration and exploitation in the supply chain positively and significantly mediate the relationship between Industry 4.0 capabilities and operational performance.Originality/valueThis study focuses on this gap to deepen the understanding of operational performance in a recent manufacturing environment under various factors and perspectives (Industry 4.0 capabilities and supply chain ambidexterity).
Interferon‐stimulated gene 15 polymorphisms are associated with spontaneous preterm birth in Taiwanese women
Authors: Chang Tzu‐Yang , Wang Liang‐Kai , Kuo Yi‐Hsiu , Chen Chia‐Yu , Pai Tun‐Wen , Chen Chie‐Pein 
Published: October 2023

AbstractProblemImmune and inflammatory responses are known to be major causes of preterm birth (PTB). The maternal genetic background plays an important role in the development of PTB. Interferon‐stimulated gene 15 (ISG15) is an interferon‐induced protein which can modulate immune cell activation and function. We aim to study if polymorphisms in the ISG15 gene are associated with spontaneous PTB (sPTB) risk in Taiwanese women.Method of studyISG15 rs4615788 C/G, rs1921 G/A, and rs8997 A/G polymorphisms were genotyped in a hospital‐based study of 112 women with sPTB and 1120 term controls. The plasma concentrations of ISG15 were determined by enzyme‐linked immunosorbent assay.ResultsWe found the ISG15 rs1921 G‐rs8997 A haplotype was associated with decreased risk for PTB (χ2 = 6.26, p = .01, pc = .04). The A/G genotype of ISG15 rs8997 polymorphism might have the potential to confer reduced risk of PTB women (χ2 = 4.09, p = .04, pc = .08). Spontaneous PTB women displayed higher plasma ISG15 levels compared to term controls (p < .001). The plasma ISG15 levels among pregnant women with rs8997 A/G genotype were found significantly lower compared to G/G genotype (p = .03).ConclusionsWomen with the ISG15 rs1921 G‐rs8997 A haplotype may associate with spontaneous PTB. These findings provide new insights into the etiology of preterm birth.
Editorial: Noninvasive tests for metabolic dysfunction‐associated steatotic liver disease: A refinement of the Nash‐FibroTest for type 2 diabetes mellitus
Authors: Liu Chen‐Hua 
Published: October 2023

LINKED CONTENTThis article is linked to Poynard et al paper. To view this article, visit https://doi.org/10.1111/apt.17688
Modelling the composition of household portfolios: A latent class approach
Authors: Alzuabi Raslan , Brown Sarah , Harris Mark N. , Taylor Karl 
Published: October 2023

AbstractWe explore portfolio allocation in Great Britain by introducing a latent class modelling approach using household panel data based on a nationally representative sample of the population, namely the Wealth and Assets Survey. The latent class aspect of the model splits households into four groups, from lowest‐wealth and least‐diversified through to highest‐wealth and most‐diversified, which serves to unveil a more detailed picture of the determinants of portfolio diversification than existing econometric approaches. A pattern of class heterogeneity is revealed that conventional econometric models are unable to identify because the statistical significance and the direction of the effect of some explanatory variables vary across the groups. For example, the effect of labour income on the number of financial assets held influences the level of diversification for the two middle classes, whereas no effect is found for households with the lowest or the highest levels of diversification. Noticeable differences in the magnitude of the effects of pension wealth and occupation are also revealed across the four classes. Such findings demonstrate the importance of accounting for latent heterogeneity when modelling financial behaviour. Ultimately, treating the population as a single homogeneous group may lead to biased parameter estimates, whereby policy based on such models could be inappropriate or erroneous.
A global analysis reveals a collective gap in the transparency of offset policies and how biodiversity is measured
Authors: Marshall Erica , Southwell Darren , Wintle Brendan A. , Kujala Heini 
Published: October 2023

AbstractOffsetting policies have increased worldwide, utilizing a range of biodiversity metrics to compensate for development impacts. We conducted a global analysis of offset legislation by reviewing policies from 108 countries, which have voluntary offsets, or which require offsets by law. We sought to understand how well biodiversity metrics and offset currencies are documented in current policies. Where biodiversity metrics are documented we aimed to understand how metrics were scored, combined, and multiplied to create offset currencies. We found only 22 jurisdictions (from 14 countries) had guidelines documenting how biodiversity should be assessed during offsetting, representing a significant gap in the guidance available for offsets. Of the 22 guidelines, 14 (63%) documented use of aggregated currencies, eight (23%) did not aggregate biodiversity metrics into a single currency, and three (17%) did not specify either approach. Habitat type and condition, as well as area, were widely recommended across policies (>50%). Where species‐level metrics were considered, guidelines generally focused on habitat distributions rather than abundance or population metrics. The lack of consistent and clear guidance about how biodiversity should be measured in offsets reduces our ability to determine the effectiveness of offsets in compensating for development impacts long term.
Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight
Authors: Kincl Vladimír , Panovský Roman , Bočková Martina , Rektor Ivan , Mojica‐Pisciotti Mary Luz , Máchal Jan 
Published: October 2023

AbstractBackgroundThe known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research.ObjectivesTo assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients.MethodsThirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR).ResultsPD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end‐diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end‐systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found.ConclusionsThis novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.
Indigenous Peoples' Lands are critical for safeguarding vertebrate diversity across the tropics
Authors: Sze Jocelyne S. , Childs Dylan Z. , Carrasco L. Roman , Fernández‐Llamazares Álvaro , Garnett Stephen T. , Edwards David P. 
Published: October 2023

AbstractIndigenous Peoples are long‐term custodians of their lands, but only recently are their contributions to conservation starting to be recognized in biodiversity policy and practice. Tropical forest loss and degradation are lower in Indigenous lands than unprotected areas, yet the role of Indigenous Peoples' Lands (IPL) in biodiversity conservation has not been properly assessed from regional to global scales. Using species distribution ranges of 11,872 tropical forest‐dependent vertebrates to create area of habitat maps, we identified the overlap of these species ranges with IPL and then compared values inside and outside of IPL for species richness, extinction vulnerability, and range‐size rarity. Of assessed vertebrates, at least 76.8% had range overlaps with IPL, on average overlapping ~25% of their ranges; at least 120 species were found only within IPL. Species richness within IPL was highest in South America, while IPL in Southeast Asia had highest extinction vulnerability, and IPL in Dominica and New Caledonia were important for range‐size rarity. Most countries in the Americas had higher species richness within IPL than outside, whereas most countries in Asia had lower extinction vulnerability scores inside IPL and more countries in Africa and Asia had slightly higher range‐size rarity in IPL. Our findings suggest that IPL provide critical support for tropical forest‐dependent vertebrates, highlighting the need for greater inclusion of Indigenous Peoples in conservation target‐setting and program implementation, and stronger upholding of Indigenous Peoples' rights in conservation policy.
Solitary Milialike Idiopathic Calcinosis Cutis: A Case Unassociated with Down Syndrome
Authors: Lee Dong Won , Yoon Dou Hee , Lee Yeun Soo , Shim Sang In , Cho Baik Kee 
Published: October 2023

AbstractWe report a unique case of solitary milialike idiopathic calcinosis cutis (MICC) in a healthy Korean woman, which is not associated with Down syndrome. This case of MICC would be a form of idiopathic calcinosis cutis, which can be solitary or multiple, sporadic or associated with Down syndrome.
Effects of different drying methods on quality and water distribution of Lycium barbarum
Authors: Zeng Tao , Liu Bin , Bi Lisen , Hu Hengxiang , Li Zhuorui , Li Rui , Shi Shengqiang , Theodorakis Panagiotis E. 
Published: October 2023

AbstractAlthough Lycium barbarum is a valuable medicinal food, it is unfortunately not easy to store due to its high moisture content. In order to maximize the preservation of the medicinal value of L. barbarum, drying is increasingly used for its storage. Motivated by the need to better understand and improve the drying of L. barbarum, in this study, the VFD (vacuum freeze drying) and HD (hot air drying) are employed as drying processes, and the rehydration ratio, drying time, specific energy consumption, sensory characteristics, moisture ratio, energy consumption, moisture mobility, and amino acids and flavonoids content of dried L. barbarum are comprehensively analyzed. The results show that, after VFD, L. barbarum has lower hardness (71.53 ± 1.68), higher rehydration ratio (1.31 ± 0.02), larger volume, plump, round and smooth surface, and similar color to the fresh L. barbarum. At the same time, compared with the sample after HD, the moisture ratio of L. barbarum after VFD is lower (1.4 ± 0.1), and its content of free water is almost negligible (2.2%). In addition, the amino acids and flavonoids content of L. barbarum after VFD are closer to those of the fresh product (133.7 μmol/g, 5.69 mg/g). Based on the analysis of the drying effect on the physical and chemical properties of L. barbarum, we conclude that VFD is a promising processing technology. However, HD proves to greatly reduce the specific energy consumption and drying time when raising the temperature appropriately, whereas VFD could not achieve the same result by increasing the heating rate of VFD.Practical applicationsIn this paper, based on the mechanism of different drying methods, the quality of L. barbarum products after drying was compared, and the water distribution in the drying process was analyzed. It is found that using VFD technology to dry L. barbarum can improve the production efficiency of L. barbarum industry and the quality of L. barbarum products. Meanwhile, the research results can provide reference for the optimization of VFD system and the scientific formulation of process parameters.
Microbiome‐based therapies for periodontitis and peri‐implantitis
Authors: Wei Xindi , Qian Shujiao , Yang Yijie , Mo Jiaji 
Published: October 2023

AbstractObjectivesPeriodontitis and peri‐implantitis are oral infectious‐inflammatory diseases associated with oral microbial dysbiosis. Microbiome‐based therapies, characterized by manipulation of the microbiota, are emerging as promising therapeutic approaches to resolve the microbial dysbiosis and associated dysregulation of immune system. This review aims at summarizing recent progress on microbiome‐based therapies in periodontitis and peri‐implantitis, promoting a further understanding of the related therapeutic mechanisms.Subjects and MethodsPertinent literatures focused on microbiome‐based therapies for periodontitis and peri‐implantitis are obtained from PubMed and Web of Science.ResultsIn this article, we review the roles and therapeutic mechanisms of four microbiome‐based therapies, including probiotics, postbiotics, predatory bacteria and phages, and microbiota transplantation, in the management of periodontitis and peri‐implantitis. Challenges facing this field are also discussed, highlighting the areas that require more attention and investigation.ConclusionsMicrobiome‐based therapies may serve as effective treatment for periodontitis and peri‐implantitis. This review presents a new viewpoint to this field.
Systematic use of half normal saline during ablation of ventricular tachycardia in structural heart disease
Authors: Cherbi Miloud , Voglimacci‐Stephanopoli Quentin , Delasnerie Hubert , Mandel Franck , Domain Guillaume , Foltran Deborah , Mondoly Pierre , Beneyto Maxime , Rollin Anne , Maury Philippe 
Published: October 2023

AbstractBackgroundEfficiency and safety of ablation using half normal saline (HNS) has been shown in refractory ventricular tachycardia (VT), but no evaluation in unselected larger populations has been made.ObjectiveTo evaluate the efficiency and safety of systematic HNS ablation in VT ablation.MethodsAll successive VT ablations in patients with structural heart disease from 2018 to 2021 used HNS in our center and were retrospectively included.ResultsOne hundred seventy‐seven successive VT ablation procedures using HNS have been performed in 148 patients (91% males, mean 64 ± 12 years, ischemic cardiomyopathy 64%, left ventricular ejection fraction 38 ± 13%). A mean of 19 ± 7.5 min of RF was delivered, with a mean power of 44 ± 7 W. Relevant complications happened in 9% (strokes 2%, tamponades 3%, atrioventricular block during septal ablations 5%). Over a mean follow‐up of 15 ± 9 months, VT recurred in 46%. Final recurrence rate after one or several procedures was 36% (18 months follow‐up). Number of VT episodes decreased from 14 ± 35 before to 2.5 ± 10 after ablation (p < .0001) and number of ICD shocks decreased from 4.8 ± 6.8 to 1.5 ± 0.8 (p = .027).ConclusionSystematic use of HNS during VT ablations in patients with structural heart disease leads to long‐term recurrences rates and complications in the range of what is reported using normal saline. Although controlled studies are needed for demonstrating the superiority of such attitude, the use of HNS in every scar‐related VT ablation seems safe for standard cases and may be furthermore useful in case of refractory arrhythmias due to difficult‐to‐ablate substrates.
The individual relationship between atrial fibrillation sources from CARTOFINDER mapping and atrial cardiomyopathy
Authors: Guckel Denise , Piran Misagh , Bergau Leonard , Hamriti Mustapha El , Fink Thomas , Sciacca Vanessa , Reil Jan‐Christian , Braun Martin , Khalaph Moneeb , Imnadze Guram , Kramer Katharina , Friedrich Sarah , Rühl Jasmin , Körperich Hermann , Sommer Philipp , Sohns Christian 
Published: October 2023

AbstractBackgroundTargeting individual sources identified during atrial fibrillation (AF) has been used as an ablation strategy with varying results.ObjectiveAim of this study was to evaluate the relationship between regions of interest (ROIs) from CARTOFINDER (CF) mapping and atrial cardiomyopathy from late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (CMR).MethodsTwenty consecutive patients underwent index catheter ablation for persistent AF (PERS AF). Pre‐processed LGE CMR images were merged with the results from CF mapping to visualize harboring regions for focal and rotational activities. Atrial cardiomyopathy was classified based on the four Utah stages.ResultsProcedural success was achieved in all patients (n = 20, 100%). LGE CMR revealed an intermediate amount of 21.41% ± 6.32% for LA fibrosis. ROIs were identified in all patients (mean no ROIs per patient n = 416.45 ± 204.57). A tendency towards a positive correlation between the total amount of atrial cardiomyopathy and the total number of ROIs per patient (regression coefficient, β = 10.86, p = .15) was observed. The degree of fibrosis and the presence of ROIs per segment showed no consistent spatial correlation (posterior: β = 0.36, p‐value (p) = .24; anterior: β = −0.08, p = .54; lateral: β = 0.31, p = 39; septal: β = −0.12; p = .66; right PVs: β = 0.34, p = .27; left PVs: β = 0.07, p = .79; LAA: β = −0.91, p = .12). 12 months AF‐free survival was 70% (n = 14) after ablation.ConclusionThe presence of ROIs from CF mapping was not directly associated with the extent and location of fibrosis. Further studies evaluating the relationship between focal and rotational activity and atrial cardiomyopathy are mandatory.
The elicitor VP2 from Verticillium dahliae triggers defence response in cotton
Authors: Qiu Ping , Zheng Baoxin , Yuan Hang , Yang Zhaoguang , Lindsey Keith , Wang Yan , Ming Yuqing , Zhang Lin , Hu Qin , Shaban Muhammad , Kong Jie , Zhang Xianlong , Zhu Longfu 
Published: October 2023

SummaryVerticillium dahliae is a widespread and destructive soilborne vascular pathogenic fungus that causes serious diseases in dicot plants. Here, comparative transcriptome analysis showed that the number of genes upregulated in defoliating pathotype V991 was significantly higher than in the non‐defoliating pathotype 1cd3‐2 during the early response of cotton. Combined with analysis of the secretome during the V991–cotton interaction, an elicitor VP2 was identified, which was highly upregulated at the early stage of V991 invasion, but was barely expressed during the 1cd3‐2‐cotton interaction. Full‐length VP2 could induce cell death in several plant species, and which was dependent on NbBAK1 but not on NbSOBIR1 in N. benthamiana. Knock‐out of VP2 attenuated the pathogenicity of V991. Furthermore, overexpression of VP2 in cotton enhanced resistance to V. dahliae without causing abnormal plant growth and development. Several genes involved in JA, SA and lignin synthesis were significantly upregulated in VP2‐overexpressing cotton. The contents of JA, SA, and lignin were also significantly higher than in the wild‐type control. In summary, the identified elicitor VP2, recognized by the receptor in the plant membrane, triggers the cotton immune response and enhances disease resistance.