bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic and risk factor analysis of cancer patients after unplanned ICU admission: a real-world multicenter study
Authors: Wei Miao , Huang Mingguang , Duan Yan , Wang Donghao , Xing Xuezhong , Quan Rongxi , Zhang Guoxing , Liu Kaizhong , Zhu Biao , Ye Yong , Zhou Dongmin , Zhao Jianghong , Ma Gang , Jiang Zhengying , Huang Bing , Xu Shanling , Xiao Yun , Zhang Linlin , Wang Hongzhi , Lin Ruiyun , Ma Shuliang , Qiu Yu’an , Wang Changsong , Zheng Zhen , Sun Ni , Xian Lewu , Li Ji , Zhang Ming , Guo Zhijun , Tao Yong , Zhang Li , Zhou Xiangzhe , Chen Wei , Wang Daoxie , Chi Jiyan 
Published: December 2023

AbstractTo investigate the occurrence and 90-day mortality of cancer patients following unplanned admission to the intensive care unit (ICU), as well as to develop a risk prediction model for their 90-day prognosis. We prospectively analyzed data from cancer patients who were admitted to the ICU without prior planning within the past 7 days, specifically between May 12, 2021, and July 12, 2021. The patients were grouped based on their 90-day survival status, and the aim was to identify the risk factors influencing their survival status. A total of 1488 cases were included in the study, with an average age of 63.2 ± 12.4 years. The most common reason for ICU admission was sepsis (n = 940, 63.2%). During their ICU stay, 29.7% of patients required vasoactive drug support (n = 442), 39.8% needed invasive mechanical ventilation support (n = 592), and 82 patients (5.5%) received renal replacement therapy. We conducted a multivariate COX proportional hazards model analysis, which revealed that BMI and a history of hypertension were protective factors. On the other hand, antitumor treatment within the 3 months prior to admission, transfer from the emergency department, general ward, or external hospital, high APACHE score, diagnosis of shock and respiratory failure, receiving invasive ventilation, and experiencing acute kidney injury (AKI) were identified as risk factors for poor prognosis within 90 days after ICU admission. The average length of stay in the ICU was 4 days, while the hospital stay duration was 18 days. A total of 415 patients died within 90 days after ICU admission, resulting in a mortality rate of 27.9%. We selected 8 indicators to construct the predictive model, which demonstrated good discrimination and calibration. The prognosis of cancer patients who are unplanned transferred to the ICU is generally poor. Assessing the risk factors and developing a risk prediction model for these patients can play a significant role in evaluating their prognosis.
Insights into time fractional dynamics in the Belousov-Zhabotinsky system through singular and non-singular kernels
Authors: Alsallami Shami A. M. , Maneea M. , Khalil E. M. , Abdel-Khalek S. , Ali Khalid K. 
Published: December 2023

AbstractIn the realm of nonlinear dynamics, the Belousov-Zhabotinsky reaction system has long held the fascination of researchers. The Belousov-Zhabotinsky system continues to be an active area of research, offering insights into the fundamental principles of nonlinear dynamics in complex systems. To deepen our understanding of this intricate system, we introduce a pioneering approach to tackle the time fractional Belousov-Zhabotinsky system, employing the Caputo and Atangana-Baleanu Caputo fractional derivatives with the double Laplace method. The solution we obtained is in the form of series which helps in investigating the accuracy of the proposed method. The primary advantage of the proposed technique lies in the low amount of calculations required and produce high degree of precision in the solutions. Furthermore, the existence and uniqueness of the solution are investigated thereby enhancing the overall credibility of our study. To visually represent our results, we present a series of 2D and 3D graphical representations that vividly illustrate the behavior of the model and the impact of changing the fractional order derivative and the time on the obtained solutions.
Lipidomic assessment of the impact of Nannochloropsis oceanica microalga lipid extract on human skin keratinocytes exposed to chronic UVB radiation
Authors: Łuczaj Wojciech , Gęgotek Agnieszka , Conde Tiago , Domingues M. Rosário , Domingues Pedro , Skrzydlewska Elżbieta 
Published: December 2023

AbstractConsiderable attention has been devoted to investigating the biological activity of microalgal extracts, highlighting their capacity to modulate cellular metabolism. This study aimed to assess the impact of Nannochloropsis oceanica lipid extract on the phospholipid profile of human keratinocytes subjected to UVB radiation. The outcomes revealed that treatment of keratinocytes with the lipid extract from microalgae led to a reduction in sphingomyelin (SM) levels, with a more pronounced effect observed in UVB-irradiated cells. Concomitantly, there was a significant upregulation of ceramides CER[NDS] and CER[NS], along with increased sphingomyelinase activity. Pathway analysis further confirmed that SM metabolism was the most significantly affected pathway in both non-irradiated and UVB-irradiated keratinocytes treated with the microalgal lipid extract. Additionally, the elevation in alkylacylPE (PEo) and diacylPE (PE) species content observed in UVB-irradiated keratinocytes following treatment with the microalgal extract suggested the potential induction of pro-survival mechanisms through autophagy in these cells. Conversely, a noteworthy reduction in LPC content in UVB-irradiated keratinocytes treated with the extract, indicated the anti-inflammatory properties of the lipid extract obtained from microalgae. However, to fully comprehend the observed alterations in the phospholipid profile of UVB-irradiated keratinocytes, further investigations are warranted to identify the specific fraction of compounds responsible for the activity of the Nannochloropsis oceanica extract.
Stem water potential estimation from images using a field noise-robust deep regression-based approach in peach trees
Authors: Yamane Takayoshi , Habaragamuwa Harshana , Sugiura Ryo , Takahashi Taro , Hayama Hiroko , Mitani Nobuhito 
Published: December 2023

AbstractField-grown peach trees are large and have a complex branch structure; therefore, detection of water deficit stress from images is challenging. We obtained large datasets of images of field-grown peach trees with continuous values of stem water potential (Ψstem) through partial secession treatment of the base of branches to change the water status of the branches. The total number of images as frames extracted from videos of branches was 23,181, 6743, and 10,752, in the training, validation, and test datasets, respectively. These datasets enabled us to precisely model water deficit stress using a deep-learning-regression model. The predicted Ψstem of frames belonging to a single branch showed a Gaussian distribution, and the coefficient of determination between the measured and predicted values of Ψstem increased to 0.927 by averaging the predicted values of the frames in each video. This method of averaging the predicted values of frames in each video can automatically eliminate noise and summarize data into the representative value of a tree and is considered to be robust for the diagnosis of water deficit stress in large field-grown peach trees with a complex branch structure.
Early life stress in women with autoimmune thyroid disorders
Authors: Corso Alessia , Engel Hermann , Müller Fabienne , Fiacco Serena , Mernone Laura , Gardini Elena , Ehlert Ulrike , Fischer Susanne 
Published: December 2023

AbstractAutoimmune thyroid disorders (AITD) represent the most frequent of all autoimmune disorders. Their aetiopathogenesis is incompletely understood, but most likely multifactorial. Early life stress can have long-lasting effects on the immune system. The aim of the present study was to investigate, for the first time, whether patients with AITD are more frequently affected by early life stress. A total of N = 208 women were recruited into a case–control study. Of these, n = 78 (median age: 53, interquartile range: 15) were patients recruited from a thyroid outpatient clinic with confirmed Hashimoto’s thyroiditis, Graves’ disease, or AITD not otherwise specified. The remaining n = 130 age- and BMI-matched women (median age: 53, interquartile range: 12) were recruited from the general population. Early life stress was measured with the Childhood Trauma Questionnaire. Patients with AITD did not differ from controls regarding sexual abuse, physical abuse, and physical neglect. However, a greater number of patients reported emotional neglect (29.7% vs. 19.5%) and emotional abuse (41.3% vs. 32%). This study provides initial evidence for emotional neglect and abuse as potential risk factors for the development of AITD. Prospective confirmation of these findings could pave the way for the development of interventions to prevent AITD in predisposed individuals.
Correct Information Unit Analysis in Different Discourse Tasks Among Persons With Anomic Aphasia Based on Mandarin AphasiaBank
Authors: Deng Bao-Mei , Liang Li-Si , Zhao Jia-Xin , Zheng Hai-Qing , Hu Xi-Quan 
Published: December 2023

Purpose:
This study aimed to explore how well persons with anomic aphasia communicate information during discourse regarding quantity, quality, and efficiency compared to neurotypical controls, to investigate the influence of discourse tasks on informativeness and efficiency and to examine impact factors like aphasia severity and cognitive ability.

Method:
Language samples of four discourse tasks from 31 persons with anomic aphasia and 31 neurotypical controls were collected from Mandarin AphasiaBank. Correct information unit (CIU) analysis measures including the total number of CIUs, percentage of CIUs, CIUs per minute, and words per minute were calculated. Group differences and the effects of discourse tasks on informativeness and efficiency were investigated. Correlations of CIU analysis measures with aphasia severity and cognitive ability were examined.

Results:
Persons with anomic aphasia showed lower efficiency in conveying information than controls. They underperformed controls on all CIU analysis measures when executing story narrative tasks. Discourse tasks influenced the informativeness and efficiency of both groups. Neurotypical controls delivered the greatest quantity of information most efficiently when narrating stories. Persons with anomic aphasia exhibited reduced quantity of information during procedural discourse and displayed superior information quality in sequential-picture descriptions. Discourse information may be impacted by aphasia severity and cognitive ability, with varying effects depending on the task.

Conclusions:
Persons with anomic aphasia are inefficient in communicating discourse messages and perform poorly on all measures in story narratives. When measuring discourse information, the effects of discourse tasks and factors like aphasia severity and cognitive ability should be considered.
Studying Conversational Adjustments in Interaction: Beyond Acoustic Phonetic Changes
Authors: Pham Catherine T. , Viswanathan Navin 
Published: December 2023

Purpose:
We examined which measures of complexity are most informative when studying language produced in interaction. Specifically, using these measures, we explored whether native and nonnative speakers modified the higher level properties of their production beyond the acoustic–phonetic level based on the language background of their conversation partner.

Method:
Using a subset of production data from the Wildcat Corpus that used Diapix, an interactive picture matching task, to elicit production, we compared English language production at the dyad and individual level across three different pair types: eight native pairs (English–English), eight mixed pairs (four English–Chinese and four English–Korean), and eight nonnative pairs (four Chinese–Chinese and four Korean–Korean).

Results:
At both the dyad and individual levels, native speakers produced longer and more clausally dense speech. They also produced fewer silent pauses and fewer linguistic mazes relative to nonnative speakers. Speakers did not modify their production based on the language background of their interlocutor.

Conclusions:
The current study examines higher level properties of language production in true interaction. Our results suggest that speakers' productions were determined by their own language background and were independent of that of their interlocutor. Furthermore, these demonstrated promise for capturing syntactic characteristics of language produced in true dialogue.

Supplemental Material:

https://doi.org/10.23641/asha.24712956
“Nobody Has a Caseload Called,
Patients With Traumatic Brain Injury
”: Rationale to Include TBI Content Into Audiology Programs
Authors: Šarkić Bojana , Douglas Jacinta Mary , Simpson Andrea 
Published: December 2023

Purpose:
Understanding the wide-ranging effects of traumatic brain injury (TBI), including posttraumatic auditory and vestibular disturbances, is an essential part of shaping audiology students' readiness for clinical practice. Several recent audiology studies revealed discrepancies in knowledge and application among practicing audiologists in Australia concerning TBI. These studies emphasize the need of exploring the existing TBI-related curriculum within Australian graduate audiology programs.

Method:
A qualitative research design employing semistructured interviews was conducted. A total of six leading academic educators from all six Australian graduate audiology programs participated in the study. Interview transcripts were analyzed using thematic analysis.

Results:
Implementation of TBI content into audiological curricula was found to be influenced by three interrelated themes: professional culture, contextual barriers, and practice of teaching and learning.

Conclusions:
The findings provide an insight into the perceived barriers associated with incorporating TBI-related content into existing audiology curricula. The findings highlight the importance of enhancing audiology curricula in relation to TBI, ensuring that graduate audiologists can provide high-quality care and management for patients with posttraumatic audiovestibular disturbances.
The Effectiveness of Slightly Thick Liquids for Improving Swallowing in Bottle-Fed Children With Aerodigestive Concerns
Authors: Mancopes Renata , Hersh Cheryl J. , Baars Rebecca , Panes Vanessa , Sorbo Jessica , Sutton Danielle , Peladeau-Pigeon Melanie , Fracchia Mary S. , Steele Catriona M. 
Published: December 2023

Purpose:
Strategies for facilitating safe and functional bottle feeding in children with dysphagia include selecting nipples that reduce flow rate, pacing, altered positioning, and thickening liquid consistencies. We aimed to determine the impact of slightly thick liquids on swallowing through retrospective review of a convenience sample of clinical videofluoroscopic swallowing studies (VFSS) from 60 bottle-fed children (21 boys and 39 girls, mean age of 9.9 months) referred due to suspected aspiration.

Method:
Eligible VFSS exams were those in which the child swallowed both thin and slightly thick barium (40% w/v Varibar barium) using the same nipple. VFSS sequences (i.e., uninterrupted portions of the VFSS recording) were randomly assigned in duplicate for rating by trained raters; discrepancies were resolved by consensus. Parameters measured included number of swallows/sequence, sucks/swallow, swallow and sequence duration, number and timing of penetration or aspiration events, laryngeal vestibule closure integrity, and pharyngeal residue. Chi-square tests, linear mixed-model analyses of variance, and Wilcoxon signed-ranks tests identified consistency effects.

Results:

There were no aspiration events in these recordings. Slightly thick liquids resulted in significantly fewer penetration events (
p
< .05), increased sucks/swallow, fewer swallows/sequence, and longer swallow and sequence durations. The number of children with ≥ 1 sequence showing pyriform sinus residue was significantly higher with slightly thick liquids.

Conclusions:
Slightly thick liquids can be effective in reducing penetration in bottle-fed children with dysphagia. However, slightly thick liquids may also lead to a safety–efficiency trade-off, with increased risk of pyriform sinus residue. Thickening for children with dysphagia should be considered only when other approaches are not effective. Overthickening should be avoided to limit negative impact on swallowing efficiency.
Analysis of the first coronagraphic multi-band observations of a sungrazing comet
Authors: Bemporad A. , Pennella S. , Battams K. , Giordano S. , Gray B. , Knight M. M. , Naletto G. , Nisticò G. , Raymond J. C. , Romoli M. , Thompson W. T. , Abbo L. , Andretta V. , Burtovoi A. , Capuano G. , Corso A. , Da Deppo V. , De Leo Y. , Fineschi S. , Frassati F. , Giarrusso M. , Guglielmino S. , Heinzel P. , Jerse G. , Landini F. , Liberatore A. , Moses D. , Nicolini G. , Pancrazzi M. , Patel R. , Romano P. , Russano G. , Sasso C. , Spadaro D. , Stangalini M. , Susino R. , Teriaca L. , Uslenghi M. 
Published: December 2023

Context. Between 24 and 25 December 2021 a sungrazing comet (SOHO-4341) approached the Sun, being observed by “classical” visible light (VL) coronagraphs on board the SOHO and STEREO missions, and also by the innovative Metis coronagraph on board the ESA-NASA Solar Orbiter mission in the VL and ultraviolet (UV H I Lyman-α) band.
Aims. We show how VL data acquired by the Metis coronagraph can be combined with those provided by other space-based coronagraphs to reconstruct the comet orbit, but also to provide information on the dust composition from the polarized VL emission. Moreover, we show how the UV emission can be employed to measure local plasma parameters of the ambient solar wind.
Methods. By using the comet positions tracked with VL Metis images (with spatial resolution that is four times better than UV), the UV images (with a time cadence that is five times faster than VL) have been coaligned to maximize the signal-to-noise ratio in the UV band. The local electron density ne was measured from the observed exponential decay of the UV Lyman-α intensity along the tail, while the solar wind speed vwind was measured from the UV Lyman-α tail inclination with respect to the cometary orbital path deprojected in 3D. Moreover, the proton kinetic temperature Tk was also obtained by the aperture angle of the UV Lyman-α tail.
Results. When the comet was at an average heliocentric distance of 14.3 R⊙, the comet had a radial speed of 155 km s−1 and a tangential speed of 59 km s−1. The comet had a UV Lyman-α tail extending in the anti-solar direction over more than 1.5 R⊙. From the analysis of the tail shape in UV we obtained the local solar wind speed (vwind = 190 km s−1), electron density (ne = 1.5 × 104 cm−3), and proton temperature (Tk = 1.2 × 106 K). Moreover, theoretical analysis of the measured UV Lyman-α intensity allowed us to estimate the radius of the cometary nucleus (Rcom = 65 m) and the water outgassing rate (QH2O = 4.8 × 1028 molec s−1).
Conclusions. These results show that sungrazing comets are unique “local probes” for the ambient coronal plasma, providing measurements that are not as affected by the line-of-sight integration effects as those provided by remote sensing instruments, in regions of the Heliosphere that are not explored in situ by the ongoing space missions.
Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Authors: Boonroumkaew Patcharaporn , Sadaow Lakkhana , Janwan Penchom , Rodpai Rutchanee , Sanpool Oranuch , Buadee Punyisa , Suprom Chanida , Thanchomnang Tongjit , Intapan Pewpan M. , Maleewong Wanchai 
Published: December 2023

Strongyloidiasis is a neglected tropical disease that can cause fatal complications due to hyperinfection and disseminated strongyloidiasis in immunocompromised patients. We used two Strongyloides stercoralis recombinant antigenic proteins, L3NieAg.01 (NIE) and IgG-immunoreactive antigen (SsIR), to develop the recombinant antigen-based immunochromatography test (ICT) kit. We constructed and compared kits using either the NIE (NIE ICT kit) or the SsIR (SsIR ICT kit) antigens and a kit using a mixture of both (NIE-SsIR ICT kit) for detection of anti-Strongyloides IgG antibody in human serum samples. Serum samples from normal healthy individuals (Group I, n = 40), proven strongyloidiasis patients (Group II, n = 100), and those with other parasitic infections (Group III, n = 154) were evaluated. Sensitivity and specificity were 81.0% and 84.0% for the NIE ICT kit, 89.0% and 83.5% for the SsIR ICT kit, and 95.0% and 90.2% for the NIE-SsIR ICT kit, respectively. The NIE-SsIR ICT kit provided the best diagnostic results; it can supplement stool examination for clinical diagnosis and can be used to screen for asymptomatic S. stercoralis infection in people at risk in endemic areas. The NIE-SsIR ICT kit can also be used in large-scale sero-epidemiological investigations in endemic areas without the need for additional facilities or ancillary supplies.
Systemisches Denken, subjektive Befunde und das diagnostische „Schubladendenken“ bei ME/CFS – Eine vorwiegend qualitative Public-Health-Studie aus Patientensicht
Authors: Habermann-Horstmeier Lotte , Horstmeier Lukas Maximilian 
Published: December 2023

Zusammenfassung
Hintergrund ME/CFS (Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom) ist eine vorwiegend als neuroimmunologische Multisystem-Erkrankung betrachtete Krankheit, die vielen Ärzt*innen in Deutschland noch immer unbekannt ist oder die von ihnen als psychosomatische Erkrankung eingeordnet wird. ME/CFS-Patient*innen berichten von den aus ihrer Sicht erheblichen Defiziten hinsichtlich der ärztlichen Behandlung und einer als problematisch empfundenen Arzt-Patienten-Beziehung (AP-Beziehung). Ziel der vorliegenden Studie ist es, aus Sicht der Betroffenen den Ablauf der Diagnosefindung als einen wichtigen Einflussfaktor auf die AP-Beziehung bei ME/CFS genauer zu analysieren.
Methode Im Rahmen eines explorativen qualitativen Surveys wurden 544 ME/CFS-Erkrankte (> 20 J.; 455 ♀, 89 ♂) mit ärztlicher ME/CFS-Diagnose schriftlich nach ihren Erfahrungen hinsichtlich des Ablaufs der Diagnosefindung befragt. Das Sampling erfolgte zuvor durch Selbstaktivierung und über das Schneeballprinzip. Der zu beantwortende Fragebogen war analog zu einem fokussierten, standardisierten Leitfadeninterview aufgebaut. Die Auswertung erfolgte im Rahmen einer qualitativen Inhaltsanalyse nach Mayring. Einige der Ergebnisse wurden anschließend quantifiziert.
Ergebnisse Die Proband*innen beschrieben den aus ihrer Sicht mangelhaften Ablauf der Diagnosefindung als zentralen Faktor einer problematischen AP-Beziehung bei ME/CFS. Sie berichteten von unzulänglichem Fachwissen, mangelnder Erfahrung im Umgang mit den Erkrankten und fehlender Fortbildungsbereitschaft der konsultierten Ärzt*innen. Viele Ärzt*innen stritten aus ihrer Sicht die Existenz von ME/CFS ab oder ordneten sie als rein psychosomatische Krankheit ein, beharrten auf ihrem Wissensstand, ignorierten das Patientenwissen und missachteten mitgebrachtes wissenschaftliches Informationsmaterial. Sie gingen nach „Standardprogramm“ vor, dachten in „Schubladen“ und seien unfähig zu systemischem Denken. Dies hätte erhebliche Auswirkungen auf die AP-Beziehung.
Diskussion Aus Sicht der ME/CFS-Erkrankten sind der Ablauf der Diagnosefindung und die Anerkennung von ME/CFS als neuroimmunologische Multisystem-Erkrankung die zentralen Aspekte einer von ihnen als problematisch erlebten AP-Beziehung. Bereits in der Vergangenheit wurden als „subjektiv“ klassifizierte und damit ignorierte Befunde, das für die biomedizinisch orientierte Medizin charakteristische diagnostische „Schubladendenken“ und ein Gesundheitssystem, das dem systemischen Denken bei der Diagnosefindung entgegensteht, als Faktoren identifiziert, die erheblichen Einfluss auf das AP-Verhältnis haben können.