bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Load Balancing Using Per Connection Classifier Method Using Mikrotik RB1100
Authors: Siagian Pedro Maldini , Hari Aspriyono  , Eko Prasetiyo Rohmawan  
Published: December 2023

The Implementation of Load Balancing Using Per Connection Classifier Method Using Mikrotik RB1100

By :
Pedro Maldini Siagian 1)
Hari Aspriyono 2)
Eko Prasetiyo Rohmawan 2)

Poltekkes Kemenkes Bengkulu as a university which has 2.000 students and 250 employees, has internet access through 2 providers, namely Icon Dedicated and Icon Broadband. Even though it has 2 internet lines, the distribution of internet line that is evenly distributed still cannot be implemented. Load Balancing carried out on Mikrotik RB1100 at Poltekkes Kemenkes Bengkulu can help distribute internet traffic evenly, and can overcome lost connections due to backing up broken connections with available connections. Load Balancing used Per Connection Classifier is a method that will send a set of packets over several existing links, taking into original account of packets. In this method, packets coming from one communication session will be routed through only one link. Through QoS (Quality of Service) testing that the result was that load balancing carried out was running well and as expected Poltekkes Kemenkes Bengkulu which can evenly distribute the connection traffic used.

Keywords : Load Balancing, Per Connection Classifier, Mikrotik RB1100, Poltekkes Kemenkes Bengkulu

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Sosial media dan digital marketplace sebagai strategi pemasaran BUM Desa
Authors: Gumilar Rendra , Nurdianti Raden Roro Suci , Sartika Sri Hardianti , Srigustini Astri 
Published: December 2023

Pemasaran merupakan salah satu aspek dalam rangka mencapai keberhasilan usaha khusunya UMKM. BUM Desa merupakan salah satu UMKM milik desa yang bertujuan untuk meningkatkan pendapatan asli desa serta kesejahteraan masyarakat desa. Kegiatan pengabdian bagi masyarakat ini memfokuskan pada pemanfaatan media sosial dan market place sebagai sarana pemasaran yang dilakukan BUM Desa. Dua BUM Desa di Kabupaten Tasikmalaya yaitu BUM Desa Cakrabuana dan BUM Desa Nanjung yang mana sudah memiliki beberapa unit usaha, diantaranya pertanian, pariwisata, kuliner, dan peternakan. Namun BUM Desa ini belum memiliki kinerja yang optimal karena terbatasnya aspek pemasaran yang digunakan. Tujuan kegiatan ini untuk menambah wawasan serta pemahaman pengelola BUM Desa tentang pemanfaatan sosial media dan digital marketplace dalam pemasaran melalui pengenalan konsep literasi digital dan E-Bisnis dalam pemasaran, yaitu Tiktok dan Instagram, serta monetisasi media social dan market place tersebut. Kegiatan ini dilakukan dengan cara diskusi dan simulasi penggunaan media sosial dan marketplace, serta simulasi pembuatan konten untuk pemasaran. Pada akhir pelatihan peserta diminta untuk mengisi kuesioner, hasil menunjukan bahwa pengetahuan peserta mengenai media sosial dan market place sebagai saran pemasaran dari 47% menjadi 93%, serta dari 37% menjadi 89% peserta akan melakukan kegiatan pemasaran secara digital. Sehingga unit usaha yang sudah dibentuk diharapkan dapat lebih optimal dengan pemasaran melalui media digital dan mampu meningkatkan keuntungan dan perekonomian desa.
Efek Coriandri fructus (Ketumbar) terhadap Slow Wave Sleep (SWS)
Authors: Indrawati Lili , D. Sitorus Truly 
Published: December 2023

Traditional remedies have been used by Indonesian people for centuries. One of them which is empirically used as hypnotic sedative is coriandri fructus. The objective of this study was to find out whether cariandri fructus could be used as a sleep medicine by measuring the sleep quality induced. In this study, a true experimental design was employed. Applying a purposive sampling method, 11 apparently healthy adult male fulfilling the inclusion criteria were selected. Each subject was induced to sleep three times, 7.5 hours each and observation through overnight polysomnography was carried out following each treatment. Lorazepam, placebo and coriandri fructus was used to induce the first, second and third sleep respectively. Parameters used in this experiments were Latency to Slow Wave Sleep, Total Time in SWS, and the distribution of SWS. This study showed that Lorazepam tend to suppress the Latency to SWS compare with the control and Coriandri fructus. There was no SWS deprivation in all groups. Lorazepam tend to suppress SWS on the last 2,5 hours of sleep.
Uji efikasi insektisida pirethroid sintetik berbahan aktif d-allethrin dan permethrin terhadap Aedes aegypti dengan aplikasi pengasapan
Authors: Suwasono Hadi , Boesri Hasan 
Published: December 2023

Aedes aegypti, vector of DHF, control has been relied on insecticides to prevent the disease transmission. Vector resistance will be speeded up by frequent use of insecticides; therefore alternative insecticides should be sought and tested. In this study, an efficacy test of insecticide containing active ingredient of d-allethrin 10% and permethrin 20% against caged Ae. aegypti hang indoor and outdoor was conducted by thermal fogging application. Both concentrations of 5 ml and 7,5 ml by product per liter diesel oil showed a knockdown effect of about 98 – 100% in less than 60 minutes. After 24 hours holding period at the laboratory about 98 – 100% of Ae.aegypti mortality was observed. It was concluded that the insecticide was effective in killing Ae. aegypti.
Faktor risiko kejadian campak di Desa Tengaran, Kecamatan Tengaran, Kabupaten Semarang, Jawa Tengah
Authors: Ambar Yuniarti Retno 
Published: December 2023

A risk factor study of measles was conducted at Tengaran Village, Tengaran Sub district, Semarang Regency, Central Java. The aim of the study was to describe distribution and risk factors of measles on the children under 15 years old. The study design was a case control study, and the data was collected retrospectively. The interview was conducted with respondents by questionnaire. Sample size was calculated using Fleiss formula for unmatched case control study employing a soft ware Epi info 6.1 program with 95% confidence limits, 80% power test and 0.05 a error. Subjects in this study were 73 for cases and 105 for control. The results showed that the immunization status had a significant correlation with measles cases (p < 0.05). Nutrition status had no significant correlation with measles cases (p > 0.05). House condition had a significant correlation with measles cases (p < 0.05), but had no significant correlation with nutrition status (p > 0.05). The education and income factor had no significant correlation with nutrition status (p > 0.05). Nevertheless, significant correlation was observed between education factor and immunization status (p < 0.05).
HUBUNGAN BERAT BADAN LAHIR RENDAH DENGAN KEJADIAN STUNTING PADA BADUTA DI DESA KONCANG, KORONCONG, DAN KADUGADUNG, KECAMATAN CIPEUCANG, KABUPATEN PANDEGLANG, BANTEN, INDONESIA
Authors: Ayuningtyas Anisa , Annisha Chita , Insani Mirza , Yuansafikri Reysaharif , Fadhilla Salma Nara , Trisiswati Maya 
Published: December 2023

Pendahuluan: Stunting adalah kondisi gagal tumbuh pada anak akibat dari kekurangan gizi kronis sehingga anak terlalu pendek untuk usianya. Pada saat anak melewati usia dua tahun, maka sudah terlambat untuk memperbaiki kerusakan pada tahun-tahun awal kehidupan. BBLR (berat badan lahir rendah) merupakan salah satu masalah kesehatan yang memerlukan perhatian di berbagai negara karena dapat mempengarhui pertumbuhan janin. Berdasarkan Penelitian prevalensi kejadian BBLR di Provinsi Banten menempati peringkat ke 9 Nasional dengan prevalensi diatas nasional (> 6,2%). Prevalensi kejadian BBLR pada desa Koncang, Keroncong, dan Kadugadung sebesar 8,70%, 14,29%, dan 7,46%. Metode: Penelitian ini menggunakan desain penelitian cross sectional dengan metode penelitian berupa survey dan pengambilan sampel secara total sampling. Uji hipotesis penelitian ini menggunakan uji ChiSquare. Hasil: Hasil analisis statistik nilai P value <0,05 yaitu nilai P 0,011 pada baduta dan nilai P 0,011 yang menunjukkan ada hubungan BBLR dengan kejadian Stunting pada baduta. Kesimpulan: Hasil analisis bivariat menunjukan ada hubungan yang signifikan atau bermakna antara BBLR dengan kejadian Stunting pada baduta dan balita di Desa Kerocong, Kecamatan Keroncong, Kabupaten Pandeglang, Provinsi Banten.
Gambaran Status Gizi dan Status Perkembangan Pada Balita Di Pos Gizi Desa tegal Angus, Tangerang
Authors: Y Yusnita , Andayani Sri Hastuti 
Published: December 2023

Indonesia masih memiliki masalah gizi pada anak dibawah lima anak dengan gizi buruk. Salah satu pendekatan nutrisi untuk menangani gizi buruk adalah dengan Deviance Positif (PD) yang mengarah pada bentuk pos gizi . Kegiatan Pos Gizi meliputi pemberian makanan tambahan, penyuluhan gizi dan kesehatan serta pemeriksaan kesehatan. Namun, evaluasi pos gizi hanya peningkatan status gizi namun status perkembangannya tidak diukur sementara gizi buruk juga mempengaruhi perkembangan anak. Penelitian ini bertujuan untuk mencari gambaran status perkembangan anak di bawah lima tahun di pos gizi. Penelitian ini adalah studi awal dengan desain cross sectional. Populasi peenlitian ini ibu dan di bawah lima anak yang berpartisipasi dalam pos gizi . Pengambilan sampel dilakukan dengan pengambilan sampel total 30 ibu dan balita. Pengukuran berat badan dengan timbangan berat badan, pengukuran status perkembangan anak tahun dilakukan melalui wawancara dan observasi dengan pedoman PEDS (Status Perkembangan Evaluasi Orang Tua). Data dianalisis secara univariat untuk memberikan gambaran tentang status gizi dan status perkembangannya. Penelitian dilakukan pada Juni 2019 di Desa Tegal Angus, Kabupaten Tangerang. Penelitian ini mengungkapkan 23,3% dari lima anak dengan status gizi buruk dan 76,7% dari status gizi kurang. Status perkembangan menunjukkan 30% risiko rendah dan 70% risiko tinggi untuk gangguan perkembangan. Aspek perkembangan yang paling terganggu adalah global, bahasa ekspresif, kemandirian dan sekolah. Hasil ini menunjukkan bahwa di bawah lima anak yang berpartisipasi dalam pos gizi membutuhkan stimulasi perkembangan.
Fabrication of ethosuximide loaded alginate/polyethylene oxide scaffolds for epilepsy research using 3D-printing method
Authors: Karabulut Hatice , Dutta Abir , Moukbil Yunis , Cisen Akyol Aysim , Ulag Songul , Aydin Banu , Gulhan Rezzan , Us Zeynep , Kalaskar Deepak M. , Gunduz Oguzhan 
Published: December 2023

Epilepsy is a medical condition that causes seizures and impairs the mental and physical activities of patients. Unfortunately, over one-third of patients do not receive adequate relief from oral Antiepileptic Drugs (AEDs) and continue to experience seizures. In addition to that, long term usage of Antiepileptic Drugs can cause a range of side effects. To overcome this problem, the precision of 3D printing technology is combined with the controlled release capabilities of biodegradable polymers, allowing for tailored and localized AED delivery to specific seizure sites. As a result of this novel technique, therapeutic outcomes can be enhanced, side effects of AEDs are minimized, and patient-specific dosage forms can be created. This study focused on the use of ethosuximide, an antiepileptic drug, at different concentrations (10, 13, and 15 mg) loaded into 3D-printed sodium alginate and polyethylene oxide scaffolds. The scaffolds contained varying concentrations (0.25%, 0.50%, and 0.75% w/v) and had varying pores created by 3D patterning sizes from 159.86 ± 19.9 µm to 240.29 ± 10.7 µm to optimize the releasing system for an intracranial administration. The addition of PEO changed the Tg and Tm temperatures from 65°C to 69°C and from 262°C to 267°C, respectively. Cytotoxicity assays using the human neuroblastoma cell line (SH-SY5Y) showed that cell metabolic activity reached 130% after 168 h, allowing the cells to develop into mature neural cells. In vitro testing demonstrated sustained ethosuximide release lasting 2 hours despite crosslinking with 3% CaCl2. The workpaves the way for the use of ethosuximide -loaded scaffolds for treating epilepsy.
Integration of RNA-seq and ATAC-seq analyzes the effect of low dose neutron-γ radiation on gene expression of lymphocytes from oilfield logging workers
Authors: Li Weiguo , Gao Gang , Pan Yan , Wang Ziqiang , Ruan Jianlei , Fan Li , Shen Yingjie , Wang Haiqing , Li Mian , Zhang Pinhua , Fang Lianying , Fu Jinghong , Liu Jianxiang 
Published: December 2023

Objective: Although radiation workers are exposed to much lower doses of neutron-γ rays than those suffered in nuclear explosions and accidents, it does not mean that their health is not affected by radiation. Lower doses of radiation do not always cause morphological aberrations in chromosomes, so more sophisticated tests must be sought to specific alterations in the exposed cells. Our goal was to characterize the specific gene expression in lymphocytes from logging workers who were continuously exposed to low doses of neutron-γ radiation. We hypothesized that the combination of cell type-specific transcriptomes and open chromatin profiles would identify lymphocyte-specific gene alterations induced by long-term radiation with low-dose neutron-γ-rays and discover new regulatory pathways and transcriptional regulatory elements.Methods: Lymphocytes were extracted from workers who have been occupationally exposed to neutron-γ and workers unexposed to radiation in the same company. mRNA-seq and ATAC-seq (Assay for Transposase-Accessible Chromatin with high-throughput sequencing) were performed, followed integrative analysis to identify specific gene regulatory regions induced by neutron-γ radiation. A qPCR assay was then performed to verify the downregulation of RNA coding for ribosomal proteins and flow cytometry was used to detect ribosomal protein expression and cell cycle alterations.Results: We identified transcripts that were specifically induced by neutron-γ radiation and discovered differential open chromatin regions that correlated with these gene activation patterns. Notably, we observed a downward trend in the expression of both differentially expressed genes and open chromatin peaks. Our most significant finding was that the differential peak upregulated in ATAC-seq, while the differential gene was downregulated in the ribosome pathway. We confirmed that neutron-γ radiation leads to transcriptional inhibition by analyzing the most enriched promoters, examining RPS18 and RPS27A expression by qPCR, and analyzing protein-protein interactions of the differential genes. Ribosomal protein expression and cell cycle were also affected by neutron-γ as detected by flow cytometry.Conclusion: We have comprehensively analyzed the genetic landscape of human lymphocytes based on chromatin accessibility and transcript levels, enabling the identification of novel neutron-γ induced signature genes not previously known. By comparing fine-mapping of open chromatin and RNA reads, we have determined that neutron-γ specifically leads to downregulation of genes in the ribosome pathway, with pseudogenes potentially playing a crucial role.
Improving lexical retrieval with LingoTalk: an app-based, self-administered treatment for clients with aphasia
Authors: Heide Judith , Netzebandt Jonka , Ahrens Stine , Brüsch Julia , Saalfrank Teresa , Schmitz-Antonischki Dorit 
Published: December 2023

IntroductionLingoTalk is a German speech-language app designed to enhance lexical retrieval in individuals with aphasia. It incorporates automatic speech recognition (ASR) to provide therapist-independent feedback. The execution and effectiveness of a self-administered intervention with LingoTalk was explored in a case series study.MethodsThree individuals with chronic aphasia participated in a highly individualized, supervised self-administered intervention lasting 3 weeks. The LingoTalk app closely monitored the frequency, intensity and progress of the intervention. Treatment efficacy was assessed using a multiple baseline design, examining both item-specific treatment effects and generalization to untreated items, an untreated task, and spontaneous speech.ResultsAll participants successfully completed the intervention with LingoTalk, although one participant was not able to use the ASR feature. None of the participants fully adhered to the treatment protocol. All participants demonstrated significant and sustained improvement in the naming of practiced items, although there was limited evidence of generalization. Additionally, there was a slight reduction in word-finding difficulties during spontaneous speech.DiscussionThis small-scale study indicates that self-administered intervention with LingoTalk can improve oral naming of treated items. Thus, it has the potential to complement face-to-face speech-language therapy, such as within in a “flipped speech room” approach. The choice of feedback mode is discussed. Transparent progress monitoring of the intervention appears to positively influence patients' motivation.
Enhancing predictive accuracy of the cardiac risk score in open abdominal aortic surgery: the role of left ventricular wall motion abnormalities
Authors: Djokic Ivana , Milicic Biljana , Matic Predrag , Ilijevski Nenad , Milojevic Milan , Jovic Miomir 
Published: December 2023

BackgroundOpen abdominal aortic surgery carries many potential complications, with cardiac adverse events being the most significant concern. The Vascular Study Group Cardiac Risk Index (VSG-CRI) is a commonly used tool for predicting severe cardiac complications and guiding clinical decision-making. However, despite the potential prognostic significance of left ventricular wall motion abnormalities (LVWMAs) and reduced LV ejection fraction (LVEF) for adverse outcomes, the VSG-CRI model has not accounted for them. Hence, the main objective of this study was to analyze the added value of LV wall motion on the discriminatory power of the modified VSG-CRI in predicting major postoperative cardiac complications.MethodsA prospective study was conducted involving 271 patients who underwent elective abdominal aortic surgery between 2019 and 2021. VSG-CRI scores were calculated, and preoperative transthoracic echocardiography was conducted for all patients. Subsequently, a modified version of the VSG-CRI, accounting for reduced LVEF and LVWMAs, was developed and incorporated into the dataset. The postoperative incidence of the composite endpoint of major adverse cardiac events (MACEs), including myocardial infarction, clinically relevant arrhythmias treated with medicaments or by cardioversion, or congestive heart failure, was assessed at discharge from the index hospitalization, with adjudicators blinded to events. The predictive accuracy of both the original and modified VSG-CRI was assessed using C-Statistics.ResultsIn total, 61 patients (22.5%) experienced MACEs. Among these patients, a significantly higher proportion had preoperative LVWMAs compared to those without (62.3% vs. 32.9%, p &lt; 0.001). Multivariable regression analysis revealed the VSG-CRI [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.21–1.77; p &lt; 0.001] and LVWMA (OR 2.76; 95% CI 1.46–5.23; p = 0.002) as independent predictors of MACEs. Additionally, the modified VSG-CRI model demonstrated superior predictability compared to the baseline VSG-CRI model, suggesting an improved predictive performance for anticipating MACEs following abdominal aortic surgery [area under the curve (AUC) 0.74; 95% CI 0.68–0.81 vs. AUC 0.70; 95% CI 0.63–0.77; respectively].ConclusionThe findings of this study suggest that incorporating preoperative echocardiography can enhance the predictive accuracy of the VSG-CRI for predicting MACEs after open abdominal aortic surgery. Before its implementation in clinical settings, external validation is necessary to confirm the generalizability of this newly developed predictive model across different populations.
Adaptive design of tipping bucket flow meters for continuous runoff measurement
Authors: Schwamback Dimaghi , Persson Magnus , Berndtsson Ronny , Anache Jamil A. A. , Wendland Edson Cezar 
Published: December 2023

Introduction: Runoff measurement and monitoring is a laborious, time-consuming, and costly task. Additionally, common runoff monitoring usually primarily provide water level, requiring information on the stage-discharge relation. Automatic equipment such as flow meter tipping bucket (TB) is a potential option to simplify and provide continuous runoff monitoring in small catchments. However, a proper description of how to size and adapt the design under different flow conditions is still lacking.Methodology: In this paper we present a novel standardized framework for the design of TB that can be used for low-cost and real-time runoff monitoring under many different conditions. The framework consists of an estimation of the runoff peak rate using the rational equation and a volumetric capacity estimate of the cavity based on runoff rate, operation speed, and inclination angle of TB when at resting position. The proposed framework was implemented in a case study where four TBs were designed for continuous runoff monitoring from experimental plots (100 m2) with different land use (sugarcane, soybean, and bare soil).Results: During field tests (five months), the designed TBs had a recovery rate of actual runoff ranging from 61% to 81% and were able to capture features poorly studied (starting/ending time and peak flow) that have potential importance in hydrological models.Discussion: The proposed framework is flexible and can be used for different environmental conditions to provide continuous runoff data records.
Carrier frequency and incidence of alpha-mannosidosis: population database-based study—focus on the East Asian and Korean population
Authors: Park Jong Eun , Lee Taeheon , Ha Kyeongsu , Cho Eun Hye , Ki Chang-Seok 
Published: December 2023

Background: Alpha-mannosidosis caused by mutations in the MAN2B1 gene is a rare genetic disorder characterized by physical abnormalities and intellectual disabilities. The objective of this study was to analyze the carrier frequency and estimated incidence of alpha-mannosidosis in East Asian populations, as limited data exists on its incidence in this group.Methods: In this study, a total of 125,748 exomes from the gnomAD database was analyzed. Additionally, 5,305 data from the KOVA and 1,722 data from the KRGDB, both representing Korean populations, were included.Results: The global carrier frequency of alpha-mannosidosis in gnomAD was 0.23%; the highest carrier frequency was observed in the Finnish at 0.49%, and East Asians had the second highest carrier frequency at 0.30%. Globally, the approximate incidence of alpha-mannosidosis was calculated at 1 in 784,535, l in 166,801 Europeans (Finnish), and l in 431,689 East Asians. By integrating the data from the 8,936 Koreans in gnomAD Korean, KOVA and KRGDB, the carrier frequency of alpha-mannosidosis in the Korean population was 0.04% and estimated incidence was 1 in 19,963,024.Conclusion: This study is the first to investigate the carrier frequencies of alpha-mannosidosis in East Asians and Koreans, including specific subpopulations, utilizing gnomAD and the Korean genomic database. The variant spectrum of MAN2B1 genes in East Asians showed significant differences compared to other ethnic groups. Our data provide valuable reference information for future investigations into alpha-mannosidosis, aiding in understanding the genetic diversity and specific variants associated with the condition in East Asian populations.