bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edoxaban and/or colchicine in outpatients with COVID-19: rationale and design of the CONVINCE trial
Authors: Landi Antonio , Morici Nuccia , Vranckx Pascal , Frigoli Enrico , Bonacchini Luca , Omazzi Barbara , Tresoldi Moreno , Camponovo Claudio , Moccetti Tiziano , Valgimigli Marco 
Published: November 2023

Background
An excessive inflammatory response and a hypercoagulable state are not infrequent in patients with coronavirus disease-2019 (COVID-19) and are associated with adverse clinical outcomes. However, the optimal treatment strategy for COVID-19 patients managed in the out-of-hospital setting is still uncertain.

Design
The CONVINCE (NCT04516941) is an investigator-initiated, open-label, blinded-endpoint, 2 × 2 factorial design randomized trial aimed at assessing two independently tested hypotheses (anticoagulation and anti-inflammatory ones) in COVID-19 patients. Adult symptomatic patients (≥18 years of age) within 7 days from reverse transcription-PCR (RT-PCR) diagnosis of SARS-CoV-2 infection managed at home or in nursery settings were considered for eligibility. Eligible patients fulfilling all inclusion and no exclusion criteria were randomized to edoxaban versus no treatment (anticoagulation hypothesis) and colchicine versus no treatment (anti-inflammatory hypothesis) in a 1 : 1:1 : 1 ratio. The study had two co-primary endpoints (one for each randomization), including the composite of major vascular thrombotic events at 25 ± 3 days for the anticoagulation hypothesis and the composite of SARS-CoV-2 detection rates at 14 ± 3 days by RT-PCR or freedom from death or hospitalizations (anti-inflammatory hypothesis). Study endpoints will be adjudicated by a blinded Clinical Events Committee. With a final sample size of 420 patients, this study projects an 80% power for each of the two primary endpoints appraised separately.

Conclusion
The CONVINCE trial aims at determining whether targeting anticoagulation and/or anti-inflammatory pathways may confer benefit in COVID-19 patients managed in the out-of-hospital setting.

Trial Registration
ClinicalTrials.gov number, NCT04516941.
Impact of proteinuria on long-term prognosis in patients with coronary artery disease
Authors: Funakubo Hiroshi , Tanaka Akihito , Tobe Akihiro , Kunieda Takeshige , Kubota Yoshiaki , Yoshioka Naoki , Otsuka Satoshi , Kudo Nobutaka , Shirai Yoshinori , Furusawa Kenji , Ishii Hideki , Murohara Toyoaki 
Published: November 2023

Background
This study aimed to investigate the association between proteinuria and long-term prognosis in patients with coronary artery disease.

Methods
This was a single-center observational study. A total of 1351 patients were identified who underwent percutaneous coronary intervention, and whose urine data were available. Patients were divided into two groups according to the presence (n = 245) or absence (n = 1106) of proteinuria. All-cause and cardiovascular deaths were primarily evaluated.

Results
The prevalence rates of hypertension and diabetes were significantly higher, and the baseline estimated glomerular filtration rate (eGFR) was lower in patients with proteinuria than in those without proteinuria. During the median follow-up of 4.1 years (interquartile range, 1.7–6.8 years), the occurrences of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria. Multivariable Cox regression analysis indicated that the presence of proteinuria was a significant predictor of cardiovascular death as well as age, BMI, reduced eGFR, and left ventricular ejection fraction. When stratified into four groups based on eGFR category (eGFR <60 or ≥60 ml/min/1.73 m2) and absence or presence of proteinuria, the incidence rates of all-cause and cardiovascular deaths were highest in patients with proteinuria and eGFR less than 60 ml/min/1.73 m2. Furthermore, the incidence rates of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria among both diabetic and nondiabetic patients.

Conclusion
Proteinuria is associated with the long-term prognosis, and all-cause and cardiovascular deaths in patients with coronary artery disease, regardless of eGFR and the presence or absence of diabetes mellitus.
Determination of taurine in soft drinks by an ultrahigh-performance liquid chromatography-mass spectrometry method
Authors: Chalova P. , Salaskova D. , Csicsay F. , Galba J. , Kovac A. , Piestansky J. 
Published: November 2023

Abstract
Taurine (2-aminoethanesulfonic acid) is a free sulfur-containing β-amino acid widely distributed in many mammalians. Owing to the energizing effects, it is mostly used in soft drinks and supplements for athletes. Regular intake of soft drinks may lead to an overdose of caffeine, taurine, and guarana and loss of bone mass, overweight, hypertension, and in older age, osteoporosis and cardiovascular diseases. Therefore, it is essential to control the maximum amount of taurine consumed by humans in the food and beverages. Here, a fast, simple, accurate, and robust method based on ultrahigh-performance liquid chromatography hyphenated with mass spectrometry (UHPLC-MS) was successfully applied for the determination of taurine in selected soft drinks sold in Slovakia. The method was characterized by coefficient of determination higher than 0.99, and the predicted value of the limit of detection was 4.29 μmol/L. The analyzed levels of taurine in selected commercial drinks ranged from 2.8 to 3.78 mg/mL. The concentration in one brand of the investigated drinks was found to be extremely low (about 70%) compared to the declared content by the manufacturer.
The Exploration and Innovation of Green Assets Securitization
Authors: Qinxin Zhou , Yulin Zhong , Fangmin Zhao 
Published: November 2023

Abstract
Green assets securitization is an important part of the green financial systematic construction. Recently, green assets securitization has developed rapidly with a stimulus of good domestic polices and increasement in green financial demand. This thesis analyzes the definition, key elements, advantages and problems of Green assets securitization and studies the cases of it. Researching the innovation of Guangyang Isle’s Green assets securitization to broaden paths and possibilities for green assets securitization.
ANALIZA OPTIMALNE DISPOZICIJE OBJEKATA NA PARCELI PRIMENOM BIM TEHNOLOGIJE I GENERATIVNOG DIZAJNA
Authors: Nikolić Filip , Lazić Marko 
Published: November 2023

Rad se bavi opmizacijom dispozicije objekata u odnosu na maksimalnu privatnost korisnika prostora u zgradi. Izrađen je algoritam kojim je ovo omogućeno. Ulazni parametri za izvršenje algoritma su 3D geometrija objekta, gabaritno okruženje okolnih objkata i linija parcele. Izlazni rezultat je optimizovana lokacija i dispozicija objekta dobijena korišćenjem specifičnog algoritma i generativnog dizajna. Tehnologija je primenjena korišćenjem Autodesk Revit softvera i Dynamo dodatka. U algoritmu su korišćene vrednosti dobijene iz literature o ljudskim čulima za model vidnog polja.
PERAN COPING STRATEGY TERHADAP ACADEMIC BURNOUT PADA MAHASISWA TINGKAT AKHIR DI JAKARTA
Authors: Antonia Doris , Monika Monika 
Published: November 2023

Pandemi COVID-19 menyebabkan banyak perubahan dalam kehidupan sehari-hari. Mahasiswa merupakan salah satu pihak yang terkena dampak dalam perubahan tersebut karena pembelajaran yang dulunya luring (luar jaringan) menjadi daring (dalam jaringan). Dalam penelitian ini, peneliti berfokus pada peran coping strategy dari mahasiswa tingkat akhir yang sedang mengerjakan tugas akhir (skripsi) terhadap academic burnout yang timbul selama mereka berada dalam masa pembelajaran daring. Metode penelitian yang digunakan dalam penelitian ini adalah kuantitatif non-eksperimental karena peneliti tidak melakukan manipulasi atau intervensi terhadap sampel penelitian. Partisipan penelitian berjumlah 202 mahasiswa (68.3% perempuan & 31.7% laki-laki) berusia 21-25 tahun dari berbagai universitas di Jakarta yang diambil menggunakan metode purposive sampling dan pengambilan sampel dilakukan secara online. Instrumen penelitian yang digunakan adalah Coping Inventory for Stressful Situation-21 dan Maslach Burnout Inventory-Student Survey yang telah diadaptasi ke Bahasa Indonesia. Analisis regresi berganda menunjukkan bahwa task focused coping (? = -0.430, p = < 0.01) dan emotion focused coping (? = 0.311, p = < 0.01) berperan secara signifikan terhadap academic burnout sebesar 28.8% tetapi tidak dengan avoidant coping (? = 0.116, p = 0.085).

The COVID-19 pandemic has caused many changes in daily life. Students are one of the affected parties in this change because learning that used to be offline (outside the network) has become online (in the network). In this research, the researcher focuses on the role of the coping strategy of final year students who are working on their final project (thesis) against academic burnout that occurs during their online learning period. The research method used in this research is non-experimental quantitative because the researcher did not manipulate or intervene on the research sample. The research participants were 202 students (68.3% female & 31.7% male) aged 21-25 years from various universities in Jakarta who were taken using purposive sampling method and the sampling was done online. The research instruments used are the Coping Inventory for Stressful Situation-21 and the Maslach Burnout Inventory-Student Survey which have been adapted into Indonesian. Multiple regression analysis showed that task focused coping (? = -0.430, p = < 0.01) and emotion focused coping (? = 0.311, p = < 0.01) had a significant role in academic burnout by 28.8% but not with avoidant coping (? = 0.116, p = 0.085).
How the supervisory board was replaced by a monitoring board in the Healthcare unit
Authors: Selivanova I. A. 
Published: November 2023

As a result of the simultaneous implementation of medical reform and corporate governance reform in Ukraine in the state and communal sectors of the economy, supervisory and supervisory boards appeared in medical enterprises. However, in 2022, supervisory boards were replaced by supervisory boards in the Fundamentals of Health Care Legislation. In order to consolidate this strange novel, the Ministry of Health of Ukraine prepared and presented for public discussion a draft resolution of the Cabinet of Ministers of Ukraine «On the supervisory board of a health care institution».
In the article, based on the analysis of the current and prospective legislation of Ukraine, scientific and practical publications and court practice, the conclusion about the different legal nature, purpose of activity, procedure of formation and competence of the supervisory board and the supervisory board is substantiated, and the illegality of replacing supervisory boards with supervisory boards is proven. The author substantiates the conclusion that the promotion of the idea of a special status of supervisory boards in health care institutions is carried out by the Ministry of Health of Ukraine with the aim of creating a collegial body to control the activities of the executive body of health care institutions of the director (directorate, board) that provide specialized medical assistance However, the means by which such a goal is achieved do not meet the requirements of the law.
Barriers to acute management of diarrhea in the home setting: An explorative study of under-five caregivers in southwestern Nigeria
Authors: Ogbo Patricia Uche , Aina Bolajoko Ajoke , Soremekun Rebecca Oritsemaje 
Published: November 2023

Objectives:
Diarrhea remains the second leading cause of morbidity and mortality among children under 5 years of age. Persistent mortality and poor outcomes despite available treatments such as oral rehydration salts (ORS) and zinc tablets are indicators of possible barriers to home management among under-five caregivers. This study was designed to explore the potential barriers encountered by under-five caregivers in providing home management for acute diarrhea within the first 24 hours of recognition.

Materials and Methods:
This qualitative study was conducted among under-five caregivers attending Primary Health Centers in Ikorodu Local Government Area of Lagos State, Nigeria. Twelve under-five caregivers, who indicated in the larger cross-sectional study that they did not provide any form of home management for the child within the first 24 hours of recognizing diarrhea were interviewed. Interviews were recorded. Naturalized transcription, peer in vivo inductive coding, and debriefing w ere done. Th ematic a nalysis was c onducted and findings were presented as themes and subthemes.

Results:
Three themes emerged: (1) Waiting for natural stoppage of diarrhea, (2) perceived function of ORS/ zinc, and (3) disconnect between potential consequences of diarrhea and action taken. Subthemes include perceived cause and seriousness of diarrhea, misdiagnosis, misinformation on the functions of ORS/ zinc from health-care providers, and lack of awareness of potential consequences of untreated diarrhea.

Conclusion:
The study showed that the main barriers to providing adequate home management were caregivers’ perception of the cause and seriousness of diarrhea and the misinformation about the function of ORS and zinc therapy. Continuous and accurate education of under-five caregivers would improve the timely initiation of ORS/ zinc and correct home management of acute diarrhea.
PENGEMBANGAN KURIKULUM MATA KULIAH UMUM BAHASA INDONESIA
Authors: Ulum Miftahul 
Published: November 2023

Kurikulum merupakan salah satu komponen penting dalam dunia pendidikan yang memiliki peran krusial dalam membentuk kualitas pendidikan suatu bangsa. Pada era globalisasi, tantangan pendidikan semakin kompleks sehingga memerlukan evaluasi dan penyempurnaan kurikulum yang ada secara terus menerus. Penelitian ini bertujuan untuk melakukan pengembangan terhadap program Mata Kuliah Umum Bahasa Indonesia pada program sarjana Universitas Negeri Semarang. Evauasi ini mencakup berbagai aspek, seperti rencana pembelajaran semester (RPS), capaian pembelajaran lulusan (CPL), capaian pembelajaran mata kuliah (CPMK), proses pembelajaran, penilaian dan evaluasi, dan bahan ajar. Penitian ini menggunakan metode kualitatif. Dalam penelitian ini terdapat beberapa perbaikan yang dilakukan dalam RPS dan bahan ajar serta saran-saran yang diberikan oleh peneliti.
Analisis Penyebab Tingginya Kasus Penyalahgunaan Narkoba di Kabupaten Aceh Utara
Authors: Sukmawati Cut , Murniati Murniati , Yunanda Rizki , Sakdiah Sakdiah , Safrina Safrina 
Published: November 2023

The issue of drug abuse and illicit trafficking is increasing every year. North Aceh District of Aceh Province is one of the districts with a high number of drug abuse cases, as in 2018 there were 124 cases of drug abuse and in 2019 there were 96 cases. This article describes the reality of the causes of high drug abuse cases in North Aceh District. The study was conducted in North Aceh District, Aceh, Indonesia, using qualitative methods in the research process. Observation, interviews and document utilization were used to collect data on the causes of high drug abuse in North Aceh district. The data collected was then classified, arranged in patterns, organized, interpreted, given meaning and concluded. This study found that there are different views, from the North Aceh local government, which is still not fully committed to the implementation of P4GN facilitation so that there is still high drug abuse, from the BNNK and North Aceh Police. The causes of the high number of cases of drug abuse and illicit trafficking in North Aceh Regency are lack of public awareness, non-existent rehabilitation facilities, the number of drug entry points into North Aceh, the existence of individual factors that cannot say NO to drugs. The influence of environmental factors (family, school and socialization), and the absence of local regulations and P4GN Action Plans.Abstrak: Permasalahan penyalahgunaan dan peredaran gelap narkotika setiap tahunnya semakin mengalami peningkatan. Kabupaten Aceh Utara Provinsi Aceh merupakan salah satu Kabupaten dengan tingginya jumlah kasus penyalahgunaan narkotika, seperti halnya tahun 2018 ada 124 kasus penyalahgunaan narkoba dan pada tahun 2019 ada 96 kasus. Artikel ini mendeskripsikan realitas penyebab tingginya kasus penyalahgunaan narkoba di Kabupaten Aceh Utara. Studi yang dilakukan di Kabupaten Aceh Utara, Aceh, Indonesia ini menggunakan metode kualitatif dalam proses penelitiannya. Observasi, wawancara (interview) dan pemanfaatan dokumen digunakan untuk mengumpulkan data tentang penyebab masih tingginya penyalahgunaan narkotika di kabupaten Aceh Utara. Data yang berhasil dikumpulkan kemudian diklasifikasikan, disusun dalam pola-pola, diorganisasikan, ditafsirkan, diberi makna dan kesimpulan. Penelitian ini menemukan bahwa ada perbedaan pandangan, dari Pemda Aceh Utara masih belum berkomitmen penuh untuk implementasi Fasilitasi P4GN sehingga masih tingginya penyalahgunaan narkoba, dari pihak BNNK dan Polres Aceh Utara. Penyebab masih tingginya kasus penyalahgunaan dan peredaran gelap narkoba di Kabupaten Aceh Utara yaitu kurangnya kesadaran masyarakat, fasilitasi rehabilitasi yang belum ada, banyaknya jalur masuk narkoba ke Aceh Utara, Adanya faktor individu yang tidak bisa berkata TIDAK pada narkoba. Adanya pengaruh faktor lingkungan (keluarga, sekolah dan pergaulan), dan belum adanya Peraturan daerah dan Rencana Aksi P4GN.
Pengaruh Literasi Keuangan Syariah, Pengetahuan, Religiusitas, Dan Uang Saku Terhadap Minat Mahasiswa Menjadi Nasabah Pada Bank Syariah (Studi Kasus Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Mataram)
Authors: Puji Lestari Dhea Indah , Cahyaningtyas Susi Retna , Isnaini Zuhrotul 
Published: November 2023

Penelitian ini bertujuan untuk menguji pengaruh literasi keuangan syariah, pengetahuan, religiusitas dan uang saku terhadap minat mahasiswa menjadi nasabah pada bank syariah (Studi Kasus Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Mataram). Penelitian ini merupakan penelitian asosiatif dengan pendekatan kuantitatif. Data yang digunakan dalam penelitian ini adalah data primer yang diperoleh melalui penyebaran kuesioner (angket) kepada responden. Sampel dalam penelitian ini adalah mahasiswa Fakultas Ekonomi dan Bisnis Universitas Mataram dengan kriteria mahasiswa aktif angkatan 2019 sampai dengan 2021 yang beragama muslim dan sudah menempuh mata kuliah ekonomi syariah sehingga total sampelnya 350 responden. Alat analisis data yang digunakan adalah Partial Least Square (PLS) versi 3.0. Hasil penelitian ini yaitu literasi keuangan syariah, pengetahuan dan religiusitas berpengaruh positif signifikan terhadap minat mahasiswa menjadi nasabah pada bank syariah. Akan tetapi, uang saku tidak berpengaruh terhadap minat mahasiswa menjadi nasabah pada bank syariah. Penelitian ini terbatas pada literasi keuangan syariah, pengetahuan, religiusitas, dan uang saku sehingga perlu dikembangkan variabel lain agar lebih mendalam seperti lingkungan sosial, teman sebaya, promosi dan lain-lain.

Kata Kunci: Literasi Keuangan Syariah, Pengetahuan, Religiusitas, Uang Saku, dan Minat Mahasiswa Menjadi Nasabah Pada Bank Syariah.
THE SURVEY OF STUDENTS INTEREST IN READING BOOK AT SMPN 1 AND SMPN 6 JAMBI CITY
Authors: Nuraini  , Zurneli Netty , Amalia Shynta 
Published: November 2023

This study aims to describe the reading interest of class VIII SMP Negeri in Jambi City. This research uses survey research method. Sampling in this study using cluster sampling technique. The number of samples in this study were 100 students from 2 well-known schools in Jambi City they are SMPN 1and SMPN 6 Jambi city. In this study, they were asked to fill out a questionnaire regarding students' reading interest as a research instrument. The data analysis technique used is descriptive analysis with quantitative data. The results showed that the reading interest of class VIII Junior High School in Jambi city was in the high category, namely 74.55%. This means that most students in the city of Jambi have a fairly high demand for reading, especially reading knowledge books.
KONSEP EKONOMI FASE PERTAMA (ABU UBAID DAN ABU YUSUF)
Authors: Athira Nur 
Published: November 2023

Kelangkaan tentang kajian pemikiran ekonomi dalam Islam sangat tidak menguntungkan, karena sepanjang sejarah, para pemikir dan pemimpin muslim telah mengembangkan berbagai gagasan ekonominya sedemikian rupa, sehingga mereka dianggap sebagai para pencetus ekonomi Islam sesungguhnya.
Analog and Mixed Signals
Authors: Melis Tommaso , Saury Luc 
Published: November 2023

Abstract
This chapter sheds light on the challenges involved in diagnosing faults in analog, mixed-signal, and RF circuits. It describes some of the work being done to leverage the benefits of standardization, improve fault simulation tools, and overcome limitations on optical fault isolation techniques. One of the solutions being considered is to integrate LEDs throughout the analog circuit, thereby using light to report the status of internal signals.
Die-Level Roadmap: Post-Isolation Domain
Authors: Narang Vinod , Zhang Chuan , Su David , Kaszuba Phil , Herschbein Steve , Langer Eckhard , von Haartman Martin , Zhu Yu , Niu Baohua , Hendarto Erwin , Nxumalo Jochonia , Otte Rik , Scott Keana 
Published: November 2023

Abstract
The first step in die-level failure analysis is to narrow the search to a specific circuit or transistor group. Then begins the post-isolation process which entails further localizing the defect, determining its electrical, physical, and chemical properties, and examining its microstructure in order to identify the root cause of failure. This chapter assesses the tools and techniques used for those purposes and the challenges brought on by continued transistor scaling, advanced 3D packages, and new IC architectures. The areas covered include sample preparation, nanoprobing, microscopy, FIB circuit edit, and scanning probe microscopy.
Leading Edge Technologies: Backside Power Delivery
Authors: Lo William , Tong Tom Xianghong 
Published: November 2023

Abstract
An architectural shift to buried power rails (BPRs) with backside power delivery (BPD) is on the horizon as CMOS technology approaches the 2 nm node. The obstruction created by the presence of BPD networks obsoletes many of the electrical fault isolation (EFI) techniques that have been used for the past few decades and severely degrades the performance of others. This chapter provides an overview of EFI methods that are still applicable to ICs with BPD networks, including e-beam and atomic force probing, x-ray and magnetic field imaging, and lock-in thermography. It assesses the technical challenges of each method as well as the potential for improvement.
Political and Economic Consequences of the U.S. Policy in Latin America
Authors: Chitadze Nika , Cheishvili Nani 
Published: November 2023

The paper explores the US policy in Latin America from the first half of the XIX Century till the modern period. US always had its geopolitical, geo economic and geostrategicinterests in Latin America, but the strategy and tactics of the official Washington`s policies in the region differed from each other, for example, during the “cold war” and afterof the “cold war” period. The changes of the US policy were depended on those political realities, which existed in Latin America during the different period of the modern worldhistory.Important part of the research is dedicated to the current socio-economic and political situation in Latin America, taking into consideration the US impact in this region.Keywords: Democratization, Geopolitics, intervention, Latin America, USA