bluuebunny/crossref_metadata_2025_split huggingface dataset:
One (photon), two(-dimensional crystals), a lot (of potential): a quick snapshot of a rapidly evolving field
Authors: Cianci Salvatore , Blundo Elena , Felici Marco 
Published: February 2024

Abstract
We present a concise overview of the state of affairs in the development of single-photon sources based on two-dimensional (2D) crystals, focusing in particular on transition-metal dichalcogenides and hexagonal boron nitride. We briefly discuss the current level of advancement (i) in our understanding of the microscopic origin of the quantum emitters (QEs) identified in these two material systems, and (ii) in the characterisation of the optical properties of these emitters; then, we survey the main methods developed to enable the dynamic control of the QEs’ emission energy. Finally, we summarise the main results stemming from the coupling of QEs embedded in 2D materials with photonic and plasmonic structures.
Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records
Authors: Titlestad Irit , Haugarvoll Kristoffer , Solvang Stein-Erik H , Norekvål Tone Merete , Skogseth Ragnhild E , Andreassen Ole A , Årsland Dag , Neerland Bjørn Erik , Nordrehaug Jan Erik , Tell Grethe S , Giil Lasse M 
Published: February 2024

Abstract

Background
In-hospital delirium is associated with adverse outcomes and is underdiagnosed, limiting research and clinical follow-up.

Objective
To compare the incidence of in-hospital delirium determined by chart-based review of electronic medical records (D-CBR) with delirium discharge diagnoses (D-DD). Furthermore, to identify differences in symptoms, treatments and delirium triggers between D-CBR and D-DD.

Method
The community-based cohort included 2,115 participants in the Hordaland Health Study born between 1925 and 1927. Between 2018 and 2022, we retrospectively reviewed hospital electronic medical records from baseline (1997–99) until death prior to 2023. D-DD and D-CBR were validated using The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for delirium.

Results
Of the 2,115 participants, 638 had in-hospital delirium. The incidence rate (IR) of D-CBR was 29.8 [95% confidence interval 28, 32] per 1,000 person-years, whereas the IR by D-DD was 3.4 [2.8, 4.2]. The IR ratio was 9.14 (P &lt; 0.001). Patients who received pharmacological treatment for delirium (n = 121, odds ratio (OR) 3.4, [2.1, 5.4], P &lt; 0.001), who were affected by acute memory impairment (n = 149, OR 2.8, [1.8, 4.5], P &lt; 0.001), or change in perception (n = 137, OR 2.9, [1.8, 4.6] P &lt; 0.001) had higher odds for D-DD. In contrast, post-operative cases (OR 0.2, [0.1, 0.4], P &lt; 0.001) had lower odds for D-DD.

Conclusion
Underdiagnosis of in-hospital delirium was a major issue in our study, especially in less severe delirium cases. Our findings emphasise the need for integrating systematic delirium diagnostics and documentation into hospital admission and discharge routines.
Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex
Authors: Koike Riki , Soeda Yoshiyuki , Kasai Atsushi , Fujioka Yusuke , Ishigaki Shinsuke , Yamanaka Akihiro , Takaichi Yuta , Chambers James K , Uchida Kazuyuki , Watanabe Hirohisa , Takashima Akihiko 
Published: February 2024

Abstract
Alzheimer’s disease is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize behavioural tasks that allow the earlier identification of signs preceding dementia that would facilitate the development of preventative and therapeutic interventions for Alzheimer’s disease. To this end, we developed a 3D virtual reality task sensitive to the activity of grid cells in the entorhinal cortex, which is the region that first exhibits neurofibrillary tangles in Alzheimer’s disease. We investigated path integration (assessed by error distance) in a spatial navigation task sensitive to grid cells in the entorhinal cortex in 177 volunteers, aged 20–89 years, who did not have self-reported dementia. While place memory was intact even in old age, path integration deteriorated with increasing age. To investigate the relationship between neurofibrillary tangles in the entorhinal cortex and path integration deficit, we examined a mouse model of tauopathy (P301S mutant tau-overexpressing mice; PS19 mice). At 6 months of age, PS19 mice showed a significant accumulation of phosphorylated tau only in the entorhinal cortex, associated with impaired path integration without impairments in spatial cognition. These data are consistent with the idea that path integration deficit is caused by the accumulation of phosphorylated tau in the entorhinal cortex. This method may allow the early identification of individuals likely to develop Alzheimer’s disease.
Switching of brain networks across different cerebral perfusion states: insights from EEG dynamic microstate analyses
Authors: Qi Xiaoying , Zhang Xin , Shen Hao , Su Jiabin , Gao Xinjie , Li Yanjiang , Yang Heng , Gao Chao , Ni Wei , Lei Yu , Gu Yuxiang , Mao Ying , Yu Yuguo 
Published: February 2024

Abstract
The alteration of neural interactions across different cerebral perfusion states remains unclear. This study aimed to fulfill this gap by examining the longitudinal brain dynamic information interactions before and after cerebral reperfusion. Electroencephalogram in eyes-closed state at baseline and postoperative 7-d and 3-month follow-ups (moyamoya disease: 20, health controls: 23) were recorded. Dynamic network analyses were focused on the features and networks of electroencephalogram microstates across different microstates and perfusion states. Considering the microstate features, the parameters were disturbed of microstate B, C, and D but preserved of microstate A. The transition probabilities of microstates A-B and B-D were increased to play a complementary role across different perfusion states. Moreover, the microstate variability was decreased, but was significantly improved after cerebral reperfusion. Regarding microstate networks, the functional connectivity strengths were declined, mainly within frontal, parietal, and occipital lobes and between parietal and occipital lobes in different perfusion states, but were ameliorated after cerebral reperfusion. This study elucidates how dynamic interaction patterns of brain neurons change after cerebral reperfusion, which allows for the observation of brain network transitions across various perfusion states in a live clinical setting through direct intervention.
Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion
Authors: Ou Yangxu , Ni Xixiu , Gao Xiaoyu , Yu Yang , Zhang Yutong , Wang Yanan , Liu Jie , Yin Zihan , Rong Jing , Sun Mingsheng , Chen Jiao , Tang Zili , Xiao Wang , Zhao Ling 
Published: February 2024

Abstract
Migraine without aura is a multidimensional neurological disorder characterized by sensory, emotional, and cognitive symptoms linked to structural and functional abnormalities in the anterior cingulate cortex. Anterior cingulate cortex subregions play differential roles in the clinical symptoms of migraine without aura; however, the specific patterns and mechanisms remain unclear. In this study, voxel-based morphometry and seed-based functional connectivity were used to investigate structural and functional alterations in the anterior cingulate cortex subdivisions in 50 patients with migraine without aura and 50 matched healthy controls. Compared with healthy controls, patients exhibited (1) decreased gray matter volume in the subgenual anterior cingulate cortex, (2) increased functional connectivity between the bilateral subgenual anterior cingulate cortex and right middle frontal gyrus, and between the posterior part of anterior cingulate cortex and right middle frontal gyrus, orbital part, and (3) decreased functional connectivity between the anterior cingulate cortex and left anterior cingulate and paracingulate gyri. Notably, left subgenual anterior cingulate cortex was correlated with the duration of each attack, whereas the right subgenual anterior cingulate cortex was associated with migraine-specific quality-of-life questionnaire (emotion) and self-rating anxiety scale scores. Our findings provide new evidence supporting the hypothesis of abnormal anterior cingulate cortex subcircuitry, revealing structural and functional abnormalities in its subregions and emphasizing the potential involvement of the left subgenual anterior cingulate cortex-related pain sensation subcircuit and right subgenual anterior cingulate cortex -related pain emotion subcircuit in migraine.
The impacts of diel thermal variability on growth, development and performance of wild Atlantic salmon (Salmo salar) from two thermally distinct rivers
Authors: Andrew Sean , Swart Sula , McKenna Stephanie , Morissette Jenna , Gillis Carole-Anne , Linnansaari Tommi , Currie Suzanne , Morash Andrea J 
Published: February 2024

Abstract
Temperature in many natural aquatic environments follows a diel cycle, but to date, we know little on how diel thermal cycles affect fish biology. The current study investigates the growth, development and physiological performance of wild Atlantic salmon collected from the Miramichi and Restigouche rivers (NB, Canada). Fish were collected as parr and acclimated to either 16–21 or 19–24°C diel thermal cycles throughout the parr and smolt life stages. Both Miramichi and Restigouche Atlantic salmon parr grew at similar rates during 16–21 or 19–24°C acclimations. However, as smolts, the growth rates of the Miramichi (−8% body mass day−1) and Restigouche (−38% body mass day−1) fish were significantly slower at 19–24°C, and were in fact negative, indicating loss of mass in this group. Acclimation to 19–24°C also increased Atlantic salmon CTmax. Our findings suggest that both life stage and river origin impact Atlantic salmon growth and performance in the thermal range used herein. These findings provide evidence for local adaptation of Atlantic salmon, increased vulnerability to warming temperatures, and highlight the differential impacts of these ecologically relevant diel thermal cycles on the juvenile life stages in this species.
Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells
Authors: Rossdam Charlotte , Brand Smilla , Beimdiek Julia , Oberbeck Astrid , Albers Marco Darius , Naujok Ortwin , Buettner Falk F R 
Published: February 2024

Abstract
Cell surface biomarkers are fundamental for specific characterization of human pluripotent stem cells (hPSCs). Importantly, they can be applied for hPSC enrichment and/or purification but also to remove potentially teratoma-forming hPSCs from differentiated populations before clinical application. Several specific markers for hPSCs are glycoconjugates comprising the glycosphingolipid (GSL)-based glycans SSEA-3 and SSEA-4. We applied an analytical approach based on multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection to quantitatively assess the GSL glycome of human embryonic stem cells and human induced pluripotent stem cells as well as during early stages of differentiation into mesoderm, endoderm, and ectoderm. Thereby, we identified the GSL lacto-N-tetraosylceramide (Lc4-Cer, Galβ1-3GlcNAcβ1-3Galβ1-4Glc-Cer), which comprises a terminal type 1 LacNAc (T1LN) structure (Galβ1-3GlcNAc), to be rapidly decreased upon onset of differentiation. Using a specific antibody, we could confirm a decline of T1LN-terminating glycans during the first four days of differentiation by live-cell staining and subsequent flow cytometry. We could further separate T1LN-positive and T1LN-negative cells out of a mixed population of pluripotent and differentiated cells by magnetic activated cell sorting. Notably, not only the T1LN-positive but also the T1LN-negative population was positive for SSEA-3, SSEA-4, and SSEA-5 while expression of nuclear pluripotency markers OCT4 and NANOG was highly reduced in the T1LN-negative population, exclusively. Our findings suggest T1LN as a pluripotent stem cell-specific glycan epitope that is more rapidly down-regulated upon differentiation than SSEA-3, SSEA-4, and SSEA-5.
AI and the future of human rights in Bangladesh: a call for robust legal and ethical frameworks
Authors: Ashraf Shadab Bin , Islam Md. Masrur 
Published: February 2024

Abstract
The rise of artificial intelligence (AI) technology presents both opportunities and challenges for the protection of human rights in Bangladesh. While AI has the potential to transform and enhance many areas of society, including healthcare, education, and business, it also raises significant ethical and legal questions that require careful consideration. This paper explores the current state of AI technology in Bangladesh and examines the potential impact on human rights, particularly in the areas of privacy, discrimination, and freedom of expression. The paper argues that while AI can be a valuable tool for promoting human rights, it can also exacerbate existing inequalities and create new forms of discrimination. To ensure that AI is used in a way that upholds human rights, the paper calls for the development of robust legal and ethical frameworks to regulate the use of AI technology. The paper proposes several recommendations for achieving this goal, including the establishment of clear ethical guidelines for the development and deployment of AI systems, the creation of a regulatory body to oversee AI technology in Bangladesh, and the use of impact assessments to identify potential risks and harms associated with AI systems. Overall, the paper emphasizes the need for a collaborative and interdisciplinary approach to addressing the legal and ethical challenges posed by AI technology in Bangladesh. By taking a proactive and holistic approach, Bangladesh can ensure that AI is developed and used in a way that respects and promotes human rights, rather than undermining them. The paper concludes by stressing the importance of ongoing research and dialogue on this critical topic to inform and guide policy and decision-making in the future.
Individual- and community-level factors associated with the presence of adequate iodized salt in households in Bangladesh: a multilevel modelling approach
Authors: Haq Iqramul , Hossain Md Ismail , Rukon Md Rukonozzaman , Habib Md Jakaria , Tithy Tanha Akther , Hasan Md Amit , Akter Salma , Rejvi Md Rayhan Ali , Uddin M Sheikh Giash , Sarker Md Mizanur Rahman , Wagnew Fasil , Talukder Ashis 
Published: February 2024

Abstract

Background
The aim of this study is to estimate the factors at both the individual and community levels related to the adequacy of iodized salt in households in Bangladesh.

Methods
For this study we utilized the 2019 Multiple Indicator Cluster Survey data. A total of 61 242 households were chosen as samples from Bangladesh. In our study of socio-economic disparities, we applied a concentration indexing method. To identify the factors associated with the adequacy of iodine in salt at both the individual and community levels, we employed multilevel logistic regression. Aside from the multilevel regression used in the study, we also applied spatial analysis.

Results
The results indicated that the prevalence of iodine adequacy in household salt was found to be 57.8% (95% confidence interval 57.4 to 58.2). Rural areas have a higher concentration of iodine than urban areas. According to the multilevel model, younger women (adjusted odds ratio [aOR] 0.70), Muslim women (aOR 0.89), illiterate women (aOR 0.80) and those from poor households (aOR 0.33) were found to be less likely to consume iodine in concentrated salt compared with their counterparts. Disabled women and those with low media exposure have a lower likelihood of iodine adequacy in salt compared to their reference group. Furthermore, households in urban areas exhibited higher odds of having iodine adequacy in salt compared with households in rural areas. Barisal, Chattogram, Dhaka, Khulna, Mymensingh, Rajshahi and Rangpur Divisions have lower iodine adequacy in salt compared with Sylhet Division.

Conclusions
The findings reveal that religion, physical disability and exposure to media exert an equal influence on the presence of iodized salt intake. Moreover, women's age, wealth status, education level and the educational background of the household head positively contribute to the adequacy of iodine in household salt. In light of these results, policymakers are advised to prioritize efforts aimed at enhancing iodine concentration, with a particular focus on mass media advertising, especially in rural areas (excluding Sylhet Division).
Stronger compensatory thermal adaptation of soil microbial respiration with higher substrate availability
Authors: Qu Lingrui , Wang Chao , Manzoni Stefano , Dacal Marina , Maestre Fernando T , Bai Edith 
Published: February 2024

Abstract
Ongoing global warming is expected to augment soil respiration by increasing the microbial activity, driving self-reinforcing feedback to climate change. However, the compensatory thermal adaptation of soil microorganisms and substrate depletion may weaken the effects of rising temperature on soil respiration. To test this hypothesis, we collected soils along a large-scale forest transect in eastern China spanning a natural temperature gradient, and we incubated the soils at different temperatures with or without substrate addition. We combined the exponential thermal response function and a data-driven model to study the interaction effect of thermal adaptation and substrate availability on microbial respiration and compared our results to those from two additional continental and global independent datasets. Modeled results suggested that the effect of thermal adaptation on microbial respiration was greater in areas with higher mean annual temperatures, which is consistent with the compensatory response to warming. In addition, the effect of thermal adaptation on microbial respiration was greater under substrate addition than under substrate depletion, which was also true for the independent datasets reanalyzed using our approach. Our results indicate that thermal adaptation in warmer regions could exert a more pronounced negative impact on microbial respiration when the substrate availability is abundant. These findings improve the body of knowledge on how substrate availability influences the soil microbial community–temperature interactions, which could improve estimates of projected soil carbon losses to the atmosphere through respiration.
Recent progress in chemoradiotherapy for oesophageal squamous cell carcinoma
Authors: Oshima Kotoe , Tsushima Takahiro , Ito Yoshinori , Kato Ken 
Published: February 2024

Abstract
Oesophageal squamous cell carcinoma is a common malignancy worldwide. Definitive chemoradiotherapy is the standard treatment for patients with resectable stage oesophageal squamous cell carcinoma who cannot undergo surgery, as well as those with locally advanced unresectable oesophageal squamous cell carcinoma. However, it has several disadvantages such as poor survival, radiation-related toxicities and severe and lethal complications related to salvage treatment for residual or recurrent disease. Numerous clinical trials on chemoradiotherapy have been conducted to confirm the optimal combination of irradiation and chemotherapy. For advanced disease, multimodal treatment strategies including salvage surgery are essential. Palliative chemoradiotherapy is also crucial for dysphagia in locally advanced oesophageal squamous cell carcinoma with or without metastatic lesions. Recently, the synergistic mechanism of radiotherapy combined with immunotherapy has been reported. Early phase clinical trials suggest that a combination of immunotherapy and chemoradiotherapy can improve clinical outcomes with manageable side effects, but further investigations are needed. Here, we reviewed the existing clinical data and current development of chemoradiotherapy combined with immunotherapy in patients with oesophageal squamous cell carcinoma.
Disparities in Demographics in Hip Arthroplasty Between U.S. Active Duty Military and the ACS-NSQIP Clinical Registry
Authors: Abraham Vivek M , Junge Joshua M , Booth Greg , Olsen Aaron A , Balazs George C , Goldman Ashton H 
Published: February 2024

ABSTRACT

Introduction
Patient demographics, such as sex and age, are known risk factors for undergoing revision following primary total hip arthroplasty (THA). The military population is unique because of the increased rates of primary and secondary osteoarthritis of the hip. Treatment options are limited for returning patients to their line of duty; however, THA has been shown to be an effective option. The primary purpose of this study was to evaluate and contrast the demographic differences of patients undergoing primary THA between the U.S. active duty military population and the general population. The secondary goal was to identify the proportion of primary THA performed at the MTF within the military health system (MHS).

Methods
This was an exempt study determined by the local institutional review board. A retrospective analysis of the MHS Data Repository (MDR) and the National Surgical Quality Improvement Program (NSQIP) was performed. The databases were used to identify the patients who underwent THA from January 1, 2015 to December 31, 2020. The MDR was used to identify demographics such as sex, age, setting of surgery, geographic location, previous military deployments, history of deployment-related injuries, branch of service, and rank. The NSQIP database was queried for sex and age. The median age of the population was compared using the Mann–Whitney U test and gender was compared using the Chi-square test.

Results
The MDR was used to evaluate 2,734 patients, whereas the NSQIP database was used to evaluate 223,832 patients. In the military population, patients who underwent THA were 87.7% male with an average age of 45 years, whereas in the general population as measured via the NSQIP database, 45.2% patients were male with an average age of 66.0 years. Comparing the two groups, we demonstrated that the military patients were significantly more likely to be younger (P &lt; .001) and males (P &lt; .001). Only 29.6% of primary THAs were performed within the MTF.

Conclusions
Patients in the MHS are undergoing THA at a younger age and are more likely to be male compared to the general population. A significant portion of primary THAs in the MHS are also being performed at civilian institutions. These demographics may result in increased risk of revision; however, long-term studies are warranted to evaluate survivorship in this unique population.