bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pensamiento económico y social de Osvaldo Sunkel para América Latina
Authors: Casanova Guerrero Ana Lucía , Paz Yaqueno Armando 
Published: November 2023

El pensamiento económico de Osvaldo Sunkel, es uno de los sustentos teóricos del modelo de desarrollo Endógeno, o Hacia Dentro, tenido en cuenta en la construcción del modelo de desarrollo neoestructural que se está ejecutando por parte de algunos gobiernos de países de América Latina como Venezuela, Ecuador y Bolivia.
Este artículo presenta un análisis crítico al sistema capitalista, más concretamente al modelo de desarrollo neoliberal o de capitalismo salvaje que se viene aplicando en Colombia desde 1989, después de treinta años de no haberse logrado solucionar los graves problemas económicos, sociales y ambientales, antes por el contrario, se han agravado; el proceso de concentración de la riqueza se ha acelerado junto con la inequitativa distribución de la misma, donde los países de la Organización para la Cooperación y el Desarrollo Económico (OCDE4) son los más favorecidos, mientras la pobreza y la miseria han crecido aceleradamente en los últimos años, especialmente en los países del tercer mundo.
Por otra parte, el sistema capitalista mundial se enfrenta a una gran crisis, que cada vez se torna en una gran depresión parecida a la de los años treinta, lo que amerita la aplicación de otra propuesta de desarrollo económico y social alternativa al pensamiento ortodoxo, como la propuesta expuesta por Osvaldo Sunkel
Suitability of excavated London clay as a supplementary cementitious material: mineralogy and reactivity
Authors: Dhandapani Yuvaraj , Marsh Alastair T. M. , Rahmon Suraj , Kanavaris Fragkoulis , Papakosta Athina , Bernal Susan A. 
Published: November 2023

AbstractThis study evaluated the potential of producing supplementary cementitious materials (SCMs) using London Clay excavated from construction activities of the High Speed 2 rail project. A trade-off between enhancing reactivity versus decomposition of impurities (e.g., pyrite, carbonates) present in different London Clay samples was considered in selecting the calcination temperature. The additional reactivity obtained by calcining at 800 °C is deemed to be worth the cost of the small additional process emissions from decomposition of carbonate minerals. Blended cement formulations were developed with the produced SCMs, with replacement levels of 50 and 70 wt%. The optimal gypsum dosage was found to be 1 wt%, which resulted in improved reaction kinetics at early ages. Mortars produced with these binders developed ~50 MPa compressive strength after 90 days of curing even with 70 wt% replacement, which is sufficient for potential production of low to medium strength concretes. These findings demonstrate the excellent potential of London Clays for SCM production and present a systematic approach for characterisation, processing and utilization of excavated mixed clays obtained from infrastructure projects.
Investigation of Protein Patterns by Using Sds Page in Kidney, Liver and Brain of Cyprinus Carpio
Authors: Sherin Mathew  , Sankarganesh P  , Baby Joseph  
Published: November 2023

Western transfer and dodecyl sodium sulphate- polyacrylamide gel electrophoresis (SDS-PAGE) are two of the most widely used and beloved techniques in cancer research to identify proteins and glycoproteins. the protein fraction expression on the protein profile is significantly lower on the seventh day than it is on the eighth, the protein fraction expression is directly inversely related to the number of days. In order to determine the number of protein bands expressed in different tissues of Cyprinus carpio exposed to mercury and lead as the number of days rose, electrophoretic research was conducted. The difference between the 27 bands for lead and 36 bands for mercury on the seventh day and the 29 bands for lead and 40 bands on the thirty-first day suggests that as the number of exposure days to lead and mercury rises, so do the number of protein bands that are expressed. Using gel electrophoresis, a mixture of proteins is categorized by kind and molecular weight in the Western Blotting method. The results are then put into a membrane, which results in the formation of a band for each protein. Two HSP70 gene bands were found in Cyprinus carpio tissues after exposure to lead and mercury.
Surgical treatment of post-traumatic instability of the shoulder joint in athletes. Аrthroscopic Latarjet procedure or free bone autograft?
Authors: Orletskiy Anatoliy  К. , Timchenko Dmitry O. , Gordeev Nikolay  A. , Zharikov Vladislav  A. , Vasiliev Dmitriy  O. , Kosov Igor  S. 
Published: November 2023

BACKGROUND: Surgical therapy for post-traumatic shoulder includes a variety of procedures, such as the Latarjet operation, Bankart, and the use of free bone autograft. Each of the offered approaches has advantages and disadvantages. As a result, techniques for plastic surgery of the articular surface of the scapula have been developed in the last 10 yr.
OBJECTIVE: To comprehensively evaluate the outcomes of biomechanical studies of the shoulder joint in the postoperative period after arthroscopic Latarjet operation and arthroscopic stabilization using a free bone graft in professional athletes.
MATERIALS AND METHODS: From 2017 to 2022, the Clinic for Sports, Ballet, and Circus Trauma, named after Z.S. Mironova (N.N. Priorov National Medical Research Center for Traumatology and Orthopedics), performed 27 arthroscopic procedures on patients with post-traumatic shoulder joint instability.
RESULT: According to the results of a comparative study of the biomechanics of the shoulder joint in the postoperative period in 27 athletes, conducted by us in the scientific department of medical rehabilitation of the N.N. Priorov, under the guidance of I.S. Kosov, it was revealed that the use of arthroscopic Latarjet operation reduces the strength characteristics of the shoulder joint and violates proprioceptive sensitivity, resulting to fine coordination of movements.
CONCLUSIONS: The surgical treatment of post-traumatic shoulder joint instability in athletes is determined by the sport. A free bone block allows you to maintain fine coordinated movements, which is vital in gymnastics, synchronized swimming, and other sports, and a free autograft does not reduce strength characteristics after surgery. The Latarjet operation can be used in team sports (basketball and volleyball) without affecting the outcome of the game.
PENGARUH LAMA PERENDAMAN DALAM PROSES PEMBUATAN AWETAN MANGGA APELL (Mangifera indica) TERHADAP DAYA TERIMA PRODUK
Authors: Maemunah Yati Setiati , Yulianti Yeni 
Published: November 2023

The purpose of this research is to analyze the influence of immersion in the process of manufacture mango apple (Mangifera indica) on the acceptance of the product. In the research of the effect of long immersion of dried apple mango fruit to the physical quality, sensory of candied apple mango products. This research uses experimental method. The result of consumer acceptance test, product of mango apple with the duration of soaking different from the duration of marinade 3 days, 5 days and 7 days are generally acceptable to the consumer by obtaining the acceptance category scales. The data obtained from the panelist assessment is somewhat trained as many as 30 people result of the research hypothesis indicate that there is influence of receipt of mango product of apple mangoes to consumer acceptance in all aspects ie color, flavor, aroma, and textur. The result of the assessment of consumer's preference level on the duration of soaking preserved apple mango with a long period of soaking for 3 days, 5 days, and 7 days is much preferred is preserved apple mango with 5 days immersion and can be recommended for further production.
Keywords: acceptance product, influence, long immersion, mango apple, manufacture.
PENERAPAN MODEL PEMBELAJARAN BLENDED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR MENGGUNAKAN APLIKASI MOODLE PADA MATA KULIAH METROLOGI INDUSTRI PROGRAM STUDI D3 TEKNIK MESIN UNIVERSITAS NEGERI JAKARTA
Authors: Sri Rahayu  
Published: November 2023

This study aims to improve learning outcomes for Industrial Metrology courses by applying the Blended Learning learning model using the web-based Moodle Application for students of the D3 Mechanical Engineering Study Program, Jakarta State University semester 111 (Odd 2019/2019). The method used in this research is Classroom Action Research (CAR) which is a form of investigation carried out by participants involved in the situation under study. Implementation of actions followed by observation and reflection activities. If necessary, at the next stage, a follow-up plan is drawn up. These efforts are carried out in a cycle to form a cycle. The place of research was conducted at the State University of Jakarta and the research subjects were 29 students of D3 Mechanical Engineering class B. This research was conducted from November 7, 2019 to December 19, 2019. Data on learning outcomes were obtained through a written test and then analyzed to compare the results of the exam in each cycle. The results of this study indicate that there is an increase in student learning outcomes in the Industrial Metrology course by applying a blended learning model using the Moodle application. The increase in learning outcomes can be seen where in the first cycle student learning outcomes with an average of 60, 11 students completed or 37.9% and 18 students have not completed or 62.1%. While in cycle II there was an increase in student learning outcomes, with an average of 77.5, 27 students completed or 93.1% and 2 students did not complete or 6.9% Researchers can conclude that student learning outcomes have increased by applying the Blended Learning learning model using the application Moodle.
Keywords: blended learning, moodle, learning outcomes, classroom action research, industrial metrology
PENGARUH PENGGUNAAN RAGI ALAMI DARI SAYURAN LOKAL TERHADAP UMUR SIMPAN ROTI TAWAR OPEN TOP
Authors: Santoni Jaja Kurnia 
Published: November 2023

This research is aimed (1) to develop natural refreshed starter based on local vegetables (2) to learn its implementation on open top toast bread (3) to observe the quality differences of open top toast bread using chinese cabbage and carrot refreshed starter, based on organoleptic aspects, physical characteristic and shelf life. This research was conducted at PT Saf Indonusa Baking Center Laboratorium, Jakarta, on November - December 2016. Experimental research was done for this research. Friedman Statistic Test and Tukey’s analysis results, showed the differences of open top toast bread final quality, using 10%, 20% and 30% chinese cabbage or carrot refreshed starter. The best finding was shown by subject’s outer color using 20% of chinese cabbage refreshed starter. Shelf life analysis showed that mold was detected on subject with 20% chinese cabbage and carrot refreshed starter on day 2; while for softness aspect of crumbs best results was showed on subject using 20% chinese cabbage and carrot based refreshed starter on day 2.
Keywords: toast bread quality, natural starter, local vegetable
EVALUASI TINGKAT KETERISIAN RUANG HENTI KHUSUS SEPEDA MOTOR DI KOTA BEKASI (STUDI KASUS: PERSIMPANGAN JL. JEND. AHMAD YANI–JL. MAYOR MADMUIN HASIBUAN–JL. KH. NOER ALI, BEKASI)
Authors: Medina Citra Ayu , Hadi Winoto , Anisah  
Published: November 2023

The purpose of this study was to get know success or failure of Advanced Stop Lines with the parameters of the level of occupancy at St. Jend Ahmad Yani – St. Mayor Madmuin Hasibuan – St. KH Noer Ali, Bekasi. The method used in supporting the implementation of this research was by using the survey method conducted at 6 - 8 am,12 pm – 1 am and 4 am – 6 am, the data obtained is the number of motorcycles in the Advanced Stop Line area and many phases are only motorized. The analysis results obtained that Advanced Stop Line Based on Modul Pelatihan Monitoring dan Evaluasi RHK 2012 was <60%. It indicates that Advanced Stop Lines at St. Jend Ahmad Yani – St. Mayor Madmuin Hasibuan – St. KH Noer Ali, Bekasi not being an appropriate solution.
The Significance of Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, and Red Cell Distribution Width in Osteoarthritis
Authors: Raveendran Dev , Perry Luke A , Bucknill Andrew , Liu Zhengyang 
Published: November 2023

Background:
The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) are routinely available inflammatory biomarkers. Their significance in osteoarthritis (OA) is poorly understood. This is a systematic review, and meta-analysis aimed to determine the association of these biomarkers with the presence and severity of OA.

Methods:
We searched MEDLINE, EMBASE, and Cochrane library for studies reporting on associations between NLR, PLR, and RDW with OA from October 1, 2022, to November 18, 2022. We generated pooled effect measures using random-effects inverse-variance modeling to compare biomarker levels in patients with OA against healthy controls. We generated pooled effect measures to compare patients with severe OA against mild/moderate OA as defined by the Kellgren-Lawrence grading scale, a classification of OA severity based on radiographic findings. We performed metaregression to explore between-study heterogeneity.

Results:
We included 20 studies involving 5,109 patients in this review. Both NLR and PLR were significantly elevated in OA. RDW was not significantly elevated with OA presence or severity. Only NLR demonstrated a significant elevation with OA severity.

Conclusions:
In this systematic review and meta-analysis, both NLR and PLR were associated with the presence of OA, whereas only NLR was associated with the severity of disease.
Analysis of chlorophyll and carotenoid compounds in eucalyptus leaves
Authors: Younes Nicolas , Cain Sophia 
Published: November 2023

Abstract
This protocol aims to extract and measure the amount of chlorophyll and carotenoids in leaf material using spectrophotometry. An ethanol extraction is used to analyse both chlorophyll a and b and carotenoids in leaf material with compounds quantified using absorbance across a range of wavelengths. This protocol uses ethanol as the extracting solution due to its affordability and safety compared to other reagents. We report a methodology that extracts pigments from whole leaf discs. The combination of extraction from leaf discs and ethanol extraction ensures this protocol is safe and rapid to complete. The protocol includes three phases: a preparation phase where samples are punched and added to ethanol (approximately 3 hours for 100 samples), an extraction phase where samples are left overnight, and a measurement phase where absorbance at a range of wavelengths is recorded using spectrophotometry (approximately 1 hour for 100 samples).
Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors
Authors: Beavis Paul , Darcy Phillip , Lai Junyun , Chan Jack , Sek Kevin , Scheffler Christina , Munoz Isabelle , Huang Yu-Kuan , Yap Kah Min , Lee Joel , Li Jasmine , Chen Amanda , Chan Cheok Weng , Derrick Emily , Todd Kirsten , Tong Junming , de Menezes Maria N. , Petley Emma , Kim Joelle , Nguyen Dat , Leung Patrick , So Joan , Deguit Christian Deo , Zhu Joe , House Imran , Kats Lev , Oliaro Jane , Parish Ian , Quinn Kylie , Neeson Paul , Slaney Clare , Saw Nicole , Dunbar Phoebe , Li Jiawen , Hoang Thang , Solomon Benjamin , Harrison Simon , Scott Andrew 
Published: November 2023

Abstract
The efficacy of chimeric antigen receptor (CAR) T cell therapy is limited in solid tumors by several factors including the immunosuppressive tumor microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. To overcome this, we sought to identify transcription factors that could enhance CAR T cell fitness. We identified that the overexpression of Foxo1 could enhance the therapeutic efficacy of murine CAR T cells in the setting of syngeneic immunocompetent models and was dependent on the sustained production of proinflammatory cytokines. FOXO1 overexpression in human CAR T cells enforced broad transcriptional and epigenetic changes that led to a more “stem-like” phenotype and similarly improved therapeutic efficacy. Enhanced efficacy was associated with improved mitochondrial fitness and persistence in vivo. FOXO1 overexpression also led to a more stem like phenotype in patient derived CAR T cells and is therefore a promising strategy for the treatment of solid cancers.
Bacterial volatile organic compounds from Bacillus zanthoxyli HS-1 enhance tolerance responses against salt and high temperature in cucumber and cabbage
Authors: Barghi Anahita , Jung Ho Won 
Published: November 2023

Abstract
Background Abiotic stresses pose significant challenges to agriculture and food security. Recent research has explored innovative approaches to enhance plant tolerance against such stresses, including the use of plant-derived compounds and plant growth-promoting rhizobacteria (PGPR). Despite this effort, identifying and characterizing PGPR as biostimulants for triggering plant tolerance response is still valuable. This study delves into how Bacillus zanthoxyli HS1 (BzaHS1) and BzaHS1-derived volatile organic compounds (VOCs) conferred systemic tolerance in cabbage and cucumber plants against salt and heat stresses.
Results Both direct application of a BzaHS1 strain and indirect exposure to BzaHS1-derived VOCs promoted seedling growth of cabbage and cucumber plants under salt- and heat-stressed conditions. This induced systemic tolerance by BzaHS1 and BzaHS1-derived VOCs accompanied by increased callose deposition and narrow stomatal aperture against salt and heat stress, respectively. Reduced proline and malondialdehyde levels were observed in cabbage and cucumber plants treated with BzaHS1 and BzaHS1-derived VOCs, indicating that these plants were less sensitive to mock-treated plants. In addition, transcription of genes encoding superoxide dismutase, catalase, and heat shock protein 70 were increased in cabbage and cucumber plants treated with BzaHS1 and BzaHS1-VOCs.
Conclusion Overall, BzaHS1 and its bVOCs show potential for enhancing salt and heat stress tolerance in plants through modulation of stress-responsive pathways involved in osmotic stress responses, regulatory processes, and antioxidant machinery.
Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poor Survival Outcome in Patients
Authors: Kimchi Adi , Meril Sara , Avni Maya Muhlbauer , Lior Chen , Bahlsen Marcela , Olender Tsviya , Savidor Alon , Krausz Judit , Peled Hila Belhanes , Birisi Hila , David Nofar , Bialik Shani , Scherz-Shouval Ruth , David Yehuda Ben 
Published: November 2023

Abstract
The non-canonical translation initiation factor EIF4G2 plays essential roles in embryonic development and differentiation, and contributes to the cellular stress response via translation of selective mRNA cohorts. Currently there is limited and conflicting information regarding the potential involvement of EIF4G2 in cancer development and progression. Endometrial cancer (EC) is the most pervasive gynecological cancer in the developed world, with increasing incidence every year. High grade ECs are largely refractory to conventional treatments, presenting poor survival rates and lacking suitable prognostic markers. Here we assayed a cohort of 280 EC patients across different types, grades, and stages, and found that low EIF4G2 expression highly correlated with poor overall and recurrence free survival in Grade 2 EC patients, monitored over a period of up to 12 years. To establish a causative connection between low EIF4G2 expression and cancer progression, we analyzed in parallel two independent human EC cell lines and demonstrated that stable EIF4G2 knock-down resulted in increased resistance to conventional therapies. Depletion of EIF4G2 also increased the prevalence of molecular markers for aggressive cell subsets, and altered their transcriptional and proteomic landscapes. Prominent among the proteins with decreased abundance were Kinesin-1 motor proteins KIF5B and KLC1, 2, 3. Multiplexed imaging of the tumors from this EC patient cohort showed a correlation between decreased protein expression of either KIF5B or KLC1, and poor survival in patients of certain grades and stages. The findings herein reveal potential novel biomarkers for Grade 2 EC with potential ramifications for patient stratification and therapeutic interventions.
Characteristics of infections with ancestral, Beta and Delta variants of SARS-CoV-2 in the PHIRST- C community cohort study, South Africa, 2020-2021
Authors: Cohen Cheryl , Kleynhans Jackie , von Gottberg Anne , McMorrow Meredith , Wolter Nicole , Bhiman Jinal N. , Moyes Jocelyn , du Plessis Mignon , Carrim Maimuna , Buys Amelia , Kahn Kathleen , Tollman Stephen , Lebina Limakatso , Wafawanaka Floidy , Toit Jacques , Gómez-Olivé Francesc Xavier , Dawood Fatimah S. , Mkhencele Thulisa , Martinson Neil , Tempia Stefano 
Published: November 2023

Abstract
Background
Data on the characteristics of individuals with mild and asymptomatic infections with different SARS-CoV-2 variants are limited. We therefore compared the characteristics of individuals infected with ancestral, Beta and Delta SARS-CoV-2 variants in South Africa.
Methods
We conducted a prospective cohort study in a rural and an urban site during July 2020-August 2021. Mid-turbinate nasal swabs were collected twice-weekly from household members irrespective of symptoms and tested for SARS-CoV-2 using real-time reverse transcription polymerase chain reaction (rRT-PCR). Differences by variant were evaluated using multinomial regression.
Results
We included 1200 individuals from 222 households and 648 rRT-PCR-confirmed infection episodes (66, 10%ancestral, 260, 40% Beta, 322, 50%Delta). Symptomatic proportion was similar for ancestral (7, 11%), Beta (44, 17%), and Delta (46, 14%) infections (p=0.4). After accounting for previous infection, peak incidence shifted to younger age groups in successive waves (40-59 years ancestral, 19-39 years Beta, 13-18 years Delta). On multivariable analysis, compared to ancestral, Beta infection was more common in individuals aged 5-12 years (vs 19-39)(adjusted odds ratio (aOR) 2.6, 95% confidence interval (CI)1.1-6.6) and PCR cycle threshold (Ct) value <30 (vs >35)(aOR 3.2, 95%CI 1.3-7.9), while Delta was more common in individuals aged <5 (aOR 6.7, 95%CI1.4-31.2) and 5-12 years (aOR 6.6 95%CI2.6-16.7)(vs 19-39) and Ct value <30 (aOR 4.5, 95%CI 1.3-15.5) and 30-35 (aOR 6.0, 95%CI 2.3-15.7)(vs >35).
Conclusions
Consecutive SARS-CoV-2 waves with Beta and Delta variants were associated with a shift to younger individuals. Beta and Delta infections were associated with higher viral loads potentially increasing infectiousness.