bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and Perspective Approaches to the Treatment of Prolactinomas
Authors: Barabash Nadiya , Tykhonova Tetiana , Kanishcheva Olena 
Published: December 2023

Background: Along with the presence of the 2011 Endocrine Society Clinical Practice Guidelines and numerous large-scale studies on the treatment of hyperprolactinemia of different origin, there are some unresolved questions, ambiguous and sometimes contradictory points of view regarding the management of patients with prolactinomas. This overview is devoted to the analysis of the results of modern clinical studies and the approaches towards the management of hyperprolactinemia caused by prolactinoma.Materials and methods: A systematic research of the literature for the appropriate keywords published mainly for the last 10 years was done; also, a reference list of each selected article was analysed. We included to our review the articles reporting controversial issues or new data on the treatment of hyperprolactinemia.Results: The review describes various problems arising during the treatment of prolactinoma. The presence of primary and secondary dopamine agonist resistance in each case requires an individual approach, and sometimes may include the use of the antineoplastic agent temozolomide. The side effects of dopamine agonists are discussed, with quite rare ones, including valvulopathy, pathological psychological conditions and cerebrospinal rhinorrhea. The controversial issue of the duration and doses of the drug used to achieve a lasting effect in the treatment of prolactinomas is considered. There are some points connected with the frequency of relapses. Thus, recurrence is correlated to the duration of treatment with dopamine agonists, prolactin levels at diagnosis, and the initial tumor size. Metformin, somatostatin analogues, selective estrogen receptor modulators, tyrosine kinase inhibitors, inhibitors of the mammalian target of rapamycin, epidermal growth factor receptor antagonists are investigated nowadays as potential alternative methods of drug treatment of prolactinomas.
Conclusion: Drug therapy with dopamine agonists makes it possible to achieve the desired results in the vast majority of patients. However, despite the proven safety of this group of medicines, the risk of side effects should still be taken into account. The therapy regimen should be determined by the clinical course of prolactinoma and the patient’s response to treatment. Other options of treatment should be considered in patients intolerant to medical therapy, with contraindication or resistance to dopamine agonists, in the case of a malignant tumor. The presence of refractory to any of the applied methods of treatment and aggressive prolactinomas leads to the search for new drugs.
PROCESS CAPABILITY ANALYSIS OF KATSUOBUSHI PRODUCTION AT PT. ABC
Authors: Soeharso Agusta Putri Balqis Linda , Kuat Pernika 
Published: December 2023

Process capability in processing fishery products is a future challenge for the fishing industry, one of which is katsuobushi. The capability process refers to how a company can produce according to specifications to make it effective and efficient. The absence of process capability in the company is the basis for stating an effective and efficient process. The proposed study is to determine the company's current condition and provide suggestions for process improvement and evaluation. Through assumptions, this study influences the results of Cp and Cpk, which are calculated by Minitab software version 21st as a method for measuring performance by identifying broad process tolerance production. In this study, the results for each data generated met data accuracy and standards. Still, at smoking 3rd and 4th stages, it was necessary to review specification values because of the value of Cpk < 1.00. As a result, after improving the standard by the six sigma concept, Cpk values are obtained > 1.00.
TARTRAZİNİN RAT PLASENTASI ÜZERİNE ETKİSİ
Authors: ÖZTÜRK Osman , KAHVECİ Selda , OKAN OFLAMAZ Aslı , UÇAR Sümeyye , YİLMAZ Seher , DOĞANYİĞİT Züleyha 
Published: December 2023

Amaç: Bu çalışmada, gıdalarda yaygın olarak kullanılan Tartrazinin, önemli sitokinlerden olan ve tümör büyümesi ile yakından ilişkili olan IL-6’nın ve hücre farklılaşması, apoptoz ile otofajide önemli rol oynayan Beklin-1 proteininin rat plasenta dokusundaki ekspresyon yoğunluğu araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Bu çalışmada, 10 adet 70-100 günlük, 250-300 gr ağırlığındaki, Sprague Dawley ırkı dişi ratlar erkek ratlarla çiftleştirilerek dişi ratların plasentaları kullanıldı. Kontrol grubu (n=5) ve Tartrazin grubu (n=5) deney hayvanları gebeliklerinin 20. gününde sakrifiye edilerek plasentaları alındı. Hematoksilen-Eozin boyamasıyla histopatolojik değerlendirmesi yapıldı ve IL-6 ile Beklin-1 ekspresyonunu analiz etmek için immünohistokimyasal olarak histolojik incelemeleri yapıldı.
Bulgular: Plasentaların histopatolojisine bakıldığında, Tartrazin grubunun kontrol grubuna kıyasla, plasenta dokularında morfolojik olarak major bir değişim görülmedi. İmmünohistokimyasal olarak, Tartrazin grubu plasenta dokusunda Labrint alanda ve glikojenik hücrelerde Beklin-1 proteininin yoğun eksprese olduğu, kontrol grubuyla kıyaslandığında ekspresyon şiddetinin istatistiksel olarak aralarında anlamlı bir farkın olduğu görüldü (p
Study of the Correlation Between Toponyms of the Irkutsk Region and Sanskrit Words
Authors: Borovsky Andrei , Rakovskaya Elena , Karteeva Inna 
Published: December 2023

The study considered the theory of correlation between sets of composite index objects. Index objects are letters of the alphabet, compound objects are words. The theory is used to find a correlation between the toponyms of the Irkutsk region and the words of the ancient language — Sanskrit. Toponyms grouped according to the names of settlements (in the amount of 1 145), rivers (141) and mountains (451) have been studied. Toponyms are compared with the vocabulary of the Sanskrit dictionary, consisting of 1 100 words. The study found a correlation between Buryat and Evenk toponyms and words from Sanskrit at the level of 62–65 %. We discussed the historical reasons for the appearance of words from Sanskrit in Eastern Siberia. We have given a large number of examples of the connection between Buryat and Evenki toponyms with words from Sanskrit and the Old Russian language.
Deconstructing women’s double burden that returned to work during the COVID-19 pandemic
Authors: Feitshans Ilise 
Published: December 2023

The double burden for women has returned during the COVID-19 pandemic. As a result of the pandemic, an unprecedented percentage of women have lost their jobs or are working from home. The COVID-19 pandemic has brought back a centuries old burden, which adds to the many other burdens women face regularly – the homework burden –, that is engaging in piecework and childcare at the same time. Mapping the laws and the legal determinants of women’s health disparities must be undertaken to stem the tide of this new wave of the feminization of poverty.
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Faktor yang mempengaruhi pengambilan keputusan metode kontrasepsi non jangka panjang pasangan usia subur Kelurahan Gadingrejo Kecamatan Gadingrejo Kota Pasuruan
Authors: Aziizah Rizka Nuur , Budijanto Budijanto , Deffinika Ifan 
Published: December 2023

The use of contraception is a method used in family planning programs to prevent and limit fertility, or delay pregnancy, so as to suppress the rate of population growth. The high rate of attainment of non-MJKP KB acceptors is because these contraceptives tend to be cheaper than the costs required for MKJP contraception, so it is not surprising that the Indonesian population, especially women of childbearing age, choose to use the Non MKJP method. The purpose of this study was to determine the factors that cause couples of childbearing age (PUS) in Gadingrejo Village, Gadingrejo District, Pasuruan to make a decision to choose a non-long-term contraceptive method (Non MKJP). This research is a quantitative descriptive study with a cross section model. The population of the study was 1143 people with sampling using simple random sampling found 92 samples of respondents. The variables studied were social, economic, and demographic factors. Data analysis with logistic regression technique with significant value (Sig less than 0.05). The results of the regression test obtained three significant factors, namely education (Sig 0.008), occupation (Sig 0.005) and duration of contraceptive use (Sig 0.001). Factors of education, occupation, and duration of contraceptive use affect respondents in choosing non-MKJP contraceptives.
Penggunaan kontrasepsi adalah cara yang dilakukan dalam program KB untuk mencegah dan membatasi fertilitas, ataupun menunda kehamilan, sehingga dapat menekan laju pertumbuhan penduduk. Tingginya angka pencapaian akseptor KB Non MJKP sebab alat kontrasepsi ini cenderung lebih murah dibandingkan dengan biaya yang diperlukan untuk kontrasepsi MKJP, maka tidak heran penduduk Indonesia khususnya perempuan usia subur menentukan memakai metode Non MKJP. Tujuan penelitian ini adalah mengetahui faktor penyebab pasangan usia subur (PUS) di Kelurahan Gadingrejo Kecamatan Gadingrejo Pasuruan mengambil keputusan memilih metode kontrasepsi non jangka panjang (Non MKJP). Penelitian ini merupakan penelitian deskriptif kuantitatif dengan model Cross Section. Populasi penelitian berjumlah 1143 jiwa dengan pengambilan sampel menggunakan simple random sampling ditemukan 92 sampel responden. Variabel yang diteliti yaitu faktor sosial, ekonomi, dan demografi. Data analisis dengan teknik regresi logistik dengan nilai signifikan (Sig kurang dari 0.05). Hasil uji regresi didapatkan tiga faktor signifikan yakni pendidikan (Sig 0.008), pekerjaan (Sig 0.005) dan lama pemakaian kontrasepsi (Sig 0.001). Faktor pendidikan, pekerjaan, dan lama pemakaian kontrasepsi mempengaruhi responden dalam pemilihan alat kontrasepsi Non MKJP.
Inhaled corticosteroids administration/withdrawal as a therapeutic continuum for patients with chronic obstructive pulmonary disease in real clinical practice
Authors: Avdeev S. N. , Aisanov Z. R. , Arkhipov V. V. , Belevskiy A. S. , Vizel A. A. , Demko I. V. , Emelyanov A. V. , Zaycev A. A. , Ignatova G. L. , Kniajeskaia N. P. , Kudelya L. M. , Leshchenko I. V. , Ovcharenko S. I. , Sinopalnikov A. I. , Trofimenko I. N. , Fedotov V. D. , Khamitov R. F. 
Published: December 2023

Chronic obstructive pulmonary disease (COPD) is a progressing disease. Each exacerbation impairs the patient’s prognosis and increases burden for the healthcare system. The most common maintenance treatment options for COPD include long-acting bronchodilators – β2-agonists (LABA) and long-acting antimuscarinic agents (LAMA), and inhaled glucocorticosteroids (ICS), in fixed/opened double and triple combinations. Triple therapy in subjects with exacerbation history is the most effective way to prevent negative outcomes of the disease. It can reduce the frequency of exacerbations, slow down the disease progression, improve quality of life, and reduce mortality in the long run. On the other hand, the response to triple therapy may change over the time depending on airways inflammation level, infection activity, and exacerbation frequency. Current COPD guidelines propose different indications for therapy escalation and de-escalation (ICS addition/withdrawal) for more personalized and safe treatment. At the same time, many practical issues of this process are still unclear, e.g. how often treatment regimens should be reviewed and what escalation/de-escalation criteria should be prioritized. The authors strongly believe that COPD therapy should adapt a holistic treatment approach (continuum) with quick responses to any changes in the patient’s condition.The aim of our work was to create an algorithm for ICS administration/ withdrawal for COPD patients on long-acting dual bronchodilators maintenance therapy and to establish a therapeutic continuum that takes into account exacerbation history, symptoms severity, blood eosinophilia level, and concomitant asthma.Conclusion. This instrument can be a useful and convenient tool for long-term patient management when access to specialized medical care might be restricted. It takes into account the main current recommendations for COPD management and is easy to apply in real clinical practice.
Ten-year analysis of the efficacy of vaccination against pneumococcal infection in patients with chronic obstructive pulmonary disease
Authors: Ignatova G. L. , Avdeev S. N. , Antonov V. N. , Blinova E. V. 
Published: December 2023

Major problems in the course of chronic obstructive pulmonary disease (COPD) include frequent exacerbations and related deaths. The use of pneumococcal vaccines, primarily a 13-valent polysaccharide conjugate vaccine, is a generally recognized tool for reducing the number of exacerbations.The aim of the study was to analyze the prospective clinical efficacy of vaccine prophylaxis with conjugated pneumococcal vaccine Prevenar-13 (PCV13) in patients with COPD over 10 years.Methods. A total of 362 male patients who were treated or monitored at the Regional Pulmonological Center of Chelyabinsk in 2012 – 2022 were enrolled in the study. The main efficacy endpoints of observation over 10 years were: the dynamics of dyspnea (mMRC score), forced expiratory volume in 1st second, the number of exacerbations, hospitalizations, the number of pneumonias. After confirming the diagnosis of COPD, the patients were divided into two observation groups. The first group (n = 150) included patients vaccinated with PCV13. The second group (n = 212) included patients with COPD who had not received pneumococcal vaccination for various reasons.Results. Severe forms of the disease and frequent exacerbations predominated in both groups. 96 (27%) deaths were recorded in the PCV13-vaccinated group, and 171 (47%) deaths in the unvaccinated group. The difference between vaccinated and unvaccinated is statistically significant (p < 0.05). In the unvaccinated patients, there was a steady progression of shortness of breath with an increase by 12% compared to baseline (p < 0.05) by the 10th year. A positive trend in FEV1 was noted in patients vaccinated with PCV13. They also showed a significant decrease in BODE prognostic index.Conclusion. The use of PCV13 allows for stabilization of the main clinical and functional indicators of the respiratory system in patients with COPD in the long term (at least 10 years of follow-up). Vaccination maintains a low risk of adverse events according to the BODE index; an increase in patient survival was noted over a 10-year horizon (odds ratio – 2.35; 95% confidence interval – 1.45; 3.77), including cases with acute viral damage with COVID-19 (COronaVIrus Disease 2019).
The macrostructure of lungs on multislice computed tomography scans in the long-term period after COVID-19 pneumonia
Authors: Kotlyarov P. M. , Soldatov D. G. , Lagkueva I. D. , Tsallagova Z. S. , Solodkiy V. A. 
Published: December 2023

The purpose of the study using MSCT monitoring data was to investigate the semiotics of residual changes in the lungs in the long-term period (up to 2 years) after pneumonia associated with COVID-19 (COronaVIrus Disease 2019).Methods. A comparative analysis of MSCT data of the chest organs was carried out in 146 patients with a confirmed diagnosis of COVID-19-associated pneumonia in 2020 – 2021 and subsequent MSCT monitoring data until 2023. MSCT was performed using a 64-slice computed tomography scanner with data post-processed on the workstation.Results. Based on the analysis, 4 groups of patients were identified that differed in the severity of viral pneumonia and the prevalence of lung lesions. The first group of patients had the most beneficial course. In 90% of cases, there was a complete resolution of the consequences of viral pneumonia in terms macroscopic changes in lung tissue by the second year of observation. In the second group, which consisted primarily of older people, 27 (52.94%) patients in year 1 and in 33 (64.7%) patients in year 2 showed a recovery of macrostructure. This group demonstrated fibrous cords, reticular changes, reactions of pleura, and residual lesions (“ground glass”). A similar trend, but in a more severe form, was observed in group 3 patients. 40 patients (86.95%) had residual changes similar to those in group 2 (middle, elderly age and older people) with the addition of bronchial wall thickening and bronchiectasis. Only in 2 (22.22%) of 9 patients with atypical manifestations of COVID-19 pneumonia in the form of “crazy paving” changes in the form of reticular seals, fibrous cords, localized thickening of the pleura and lymphadenopathy persisted up to 2 years of observation.Conclusion. MSCT monitoring of the lungs of patients suffering from COVID-19-associated pneumonia up to 2 years after recovery showed that the prevalence and severity of post-COVID changes in the lungs depends on the severity of the disease (degree and nature of damage to the pulmonary parenchyma) and the patient’s age.
Oscillometry: clinical significance and applications
Authors: Kiryukhina L. D. , Chernyak A. V. 
Published: December 2023

Oscillometry (the forced oscillation technique) is widely used in the Russian Federation. It is a simple, noninvasive functional diagnostic test that offers unique advantages in cases where spirometry and other pulmonary function tests are not appropriate, such as in young children, debilitated patients, or patients with physical and cognitive barriers to performing tests that require effort and coordination.The aim of this study was to analyze scientific literature data and our own results and to evaluate the significance and applications of oscillometry in clinical practice. The review examined the physiological principles of oscillometry and the basis for interpreting the results. Oscillometry is now recognized as a sensitive diagnostic tool for assessing airway resistance. This article describes sensitivity of the method for bronchodilation and bronchoprovocation tests, as well as its response to drug treatment, especially in asthma and chronic obstructive pulmonary disease. Oscillometry is a useful tool for diagnosing obstructive ventilation disorders. It should be used as an addition to spirometry to clarify phenotypes of small airways diseases. However, despite its great promise as a useful diagnostic tool, further evidence of its clinical utility in restrictive conditions is needed.Conclusion. Thus, oscillometry can be considered an addition and sometimes an alternative to spirometry and bronchodilation test, since it is well standardized. The test results are highly reproducible, the study does not require maximum effort, and the test is carried out during spontaneous tidal breathing.
Art Deco Sanat Akımı ile “Bulut” ve “Çintemani” Motiflerinin Yeni Tasarımlarda Kullanımı
Authors: CORUH Ebru , ATALAN Dilara Nur 
Published: December 2023

Her kültürün kendine ait motifleri, desenleri, sembol ve simgeleri bulunmaktadır. Bu motifler ait oldukları
medeniyetin kültürü, inanışları, efsane ve mitleri hakkında bilgiler verir. Uzun yıllardır aktarılarak günümüze
gelen motiflerden bir kısmı tek bir millet ile özdeşleşmiş, bir kısmı da birçok milletin ortak noktası haline
gelmiştir.
Farklı inançlar ve farklı zevk unsurları sebebi ile motiflerin birçoğu zaman içerisinde, kültürlerarası
etkileşim sonucunda değişikliğe uğramıştır. Birbirlerinden etkilenerek farklı tarz ve üsluplar ile yorumlanan
motifler günümüzde pek çok alanda tercih edilmekte ve tasarımcılara ilham kaynağı olmaktadır. Bu
çalışma kapsamında “çintemani” ve “bulut” motifleri ele alınarak ejderha motifi ve art deco sanat akımı
eşliğinde yorumlanmıştır. Bu motifler geleneksel Türk sanatları ve Uzak Doğu sanatlarında uzun yıllardır
kullanılmaktadır. Farklı iki kültürün ortak motiflerinden biri olarak, minyatür ve çini sanatlarında en çok
tercih edilen motiflerin başında gelmektedir. Bu çalışmada yeni ve özgün bir tasarım ortaya çıkarılarak,
eskiz çalışması, dijital renklendirmesi ve dijital olarak ürün üzerinde sunumu gösterilmiştir.
Yeni Avrupa Bauhaus Kavramı ile Geleceğe Yönelik Yaşam Biçimlerini Tasarlamak
Authors: BEKCİ Banu 
Published: December 2023

Şehirleşmede yaşanan planlama süreçlerindeki başarısızlıklar yöneticiler ve farklı meslek disiplinlerinin
planlama süreçlerine bütüncül yaklaşamamalarından kaynaklanmaktadır. Uluslararası platformlarda
hissedilen bu süreç küresel ve finansal yoksunluğa karşı aranan ekonomik yaklaşımlarda rekabet gücünü
arttırıcı tedbir ve sürdürülebilir tasarım arayışlarını gündeme getirerek kent planlama ve tasarımlarındaki
yapılı çevrelerde yeni bir statükonun sorgulanmasını gündeme getirmiştir. Bu bağlamda Avrupa “Yeşil
Düzen” kavramının küresel etkileri ele alınarak yeşil düzene destek olabilecek sektörlerin neler olacağı, bu
sektörlerin süreçten nasıl destekleneceği ve süreç içerisindeki dönüşümün nasıl ve hangi enstrümanlarla
gerçekleşeceği çalışmanın çıkış noktasını oluşturmaktadır. “Avrupa Yeşil Mutabakatına” paralel olarak
geliştirilen “Avrupa Yeşil Anlaşması” ile yürürlükte olan yasalara yönelik yeni düzenlemelerin ve değişikliklerin
önü açılarak Avrupa ve yakın çevresinin korunması amaçlanmaktadır. Yeni Bauhaus akımı olarak yorumlanan
bu süreç Bauhaus akımının karşılaştığı bütün olumsuz koşulları günümüzde yeşil yenilenme sürecinin bir
başkaldırışı olarak görülmektedir. Çalışmada kentsel mekânlara ait planlamalardaki kolektif diyaloglar
üzerinde durularak “İnsan-Doğa” dengesini koruyan yeşil kentsel planlama süreci hakkında bilgi verilmiştir.
¿Cuál es el efecto del rol de las mujeres rurales sobre la adecuada cloración del agua? Evidencia para el caso peruano
Authors: Sotelo Tornero Marisela , Arias Callupe Waldir 
Published: December 2023

Esta investigación analiza la relevancia del rol de las mujeres rurales sobre la adecuada cloración del agua, considerando una evaluación a nivel nacional rural, así como las diferencias que existen entre los centros poblados concentrados y dispersos. Este estudio enfoca su análisis en aquellos centros poblados con menos de 2000 habitantes y que son abastecidos en los servicios de agua y alcantarillado por algún prestador rural denominado en Perú organización comunal. De acuerdo con la revisión de la literatura, se sugiere que, una escasa participación de las mujeres en organizaciones comunales representa uno de los factores que contribuyen a que el índice de agua apta para consumo humano siga siendo muy bajo. En esta línea, para llevar a cabo el estudio, se emplearon los datos recopilados del informe Diagnóstico sobre el abastecimiento de agua y saneamiento en el ámbito rural - DATASS 2020, publicado por el Ministerio de Vivienda, Construcción y Saneamiento (MVCS) (2020), que brinda información sobre los servicios de saneamiento en los centros poblados rurales. Las afirmaciones planteadas en la hipótesis se validan en la sección Resultados mediante un análisis de regresión probabilística, utilizando un índice de calidad del servicio de agua que se representa a través de la adecuada cloración de la misma.
AVALIAÇÃO DO DIAGNÓSTICO DO DESEMPENHO DOS ALUNOS DO ENSINO MÉDIO NA OLIMPÍADA TOCANTINENSE DE QUÍMICA: UM ESTUDO DE CASO DO PROGRAMA OLÍMPIADAS NACIONAIS DE QUÍMICA
Authors: Fernandes da Silva Lívia , Cavalcante da Silva José Expedito 
Published: December 2023

O estudo visa avaliar o desenvolvimento de aprendizado dos alunos do Ensino Médio do Tocantins a respeito da percepção dos conteúdos programático curriculares, frente às respostas as questões problemas dos exames da Olimpíada Tocantinense de Química 2015. O estudo foi desenvolvido com o intuito de verificar se há ou não, uma maior aprendizagem do aluno em determinados conteúdos e como esse conhecimento se efetiva em uma avalição somativa. Com os resultados obtidos pôde-se verificar que o desempenho da rede pública foi inferior a rede particular em todos os anos e que a evolução de aprendizados dos conteúdos se mostrou mais desuniforme na rede pública demostrando descontinuidade na compreensão dos conteúdos.
PALAVRAS-CHAVE: Olimpíada de Química; Diagnóstico de aprendizagem; Ensino médio.