bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Significance of Serum Sclerostin in Early Detection of Rheumatoid Arthritis in Syrian Patients
Authors: Hussein Rama , Aboukhamis Imad 
Published: November 2023

Background:
Rheumatoid arthritis (RA) is associated with joint deformities and local bone erosions. Sclerostin is an inhibitor of the Wnt pathway and drives to reduce bone formation.

Aims:
Our study aimed to compare the diagnostic significance of sclerostin with anti-CCP (anti-cyclic citrullinated peptide; normal level<20 IU/ml, and rheumatoid factor (RF; normal level<16 IU/ml) for the early diagnosis of rheumatoid arthritis in Syrian patients.

Methods:
This study contained fifty-eight RA patients and thirty healthy individuals who were equally age- and sex-matched. Serum sclerostin and serum anti-CCP (IgG) levels were evaluated by using the enzyme-linked immunosorbent assay (ELISA). RA activity was assessed based on disease activity scores (DAS28).

Results:
Our results indicated that serum levels of sclerostin levels were higher in the RA group than in the healthy group (p<0.001). There was a positive correlation between serum sclerostin and DAS28-ESR (r=0.413, p=0.001). By ROC curve, the most optimal cut-off value of sclerostin was 249.69 pg/ml (AUC was 0.910 with 95% confidence interval (CI) values (0.852-0.969), sensitivity of 87.9%, and specificity of 93.3%) [Odds Ratio (OR) and P-value: 102, P< 0.0001]. In RA patients, the sensitivity and specificity of anti-CCP were 74.1% and 90%, and 70.6% and 86.6% of RF, respectively.

Conclusion:
Increased serum sclerostin may aid as a new prognostic biomarker for evaluating the activity of RA. Sclerostin showed higher sensitivity and specificity than anti-CCP and RF-IgM antibodies. Therefore, sclerostin is a sensitive and specific biomarker for early diagnosis of rheumatoid arthritis.
Decision-making Support System for Predicting and Eliminating Malnutrition and Anemia
Authors: Maasthi Manasvi Jagadeesh , Gururaj Harinahalli Lokesh , Ravi Vinayakumar , D Basavesha , Almeshari Meshari , Alzamil Yasser 
Published: November 2023

Aims:
This study investigates predicting and eliminating malnutrition and anemia using ML Algorithms and comparing all the methods with various malnutrition-based parameters.

Background:
The health of the nation is more important than the wealth of the nation. Malnutrition and anemia are serious health issues but the least importance is given to eradicate them.

Objective:
Proper nutrition is an essential component for the survival, growth, and development of infants, children, and women who in turn give birth to infants.

Methods:
In the proposed system, machine learning approaches are utilized to predict the malnutrition status of children under five years of age and anemia in men and women using old datasets and further providing a suitable diet recommendation to overcome the disease. Classification techniques are being used for malnutrition as well as anemia prediction.

Results:
Algorithms such as Naïve Bayes classifier (NBC), Decision Tree (DT) algorithm, Random Forest (RF) algorithm, and K-Nearest Neighbor (k-NN) algorithm are utilized for prediction. The results obtained by these algorithms are 94.47%, 85%, 95.49%, and 63.15%. When compared, Naïve Bayes and random forest algorithm provided efficient results for malnutrition and anemia, respectively.

Conclusion:
By testing and validating, preventive actions can be taken with the help of medical experts and dieticians to reduce malnutrition and anemia conditions among children and elders, respectively.
Policies and Models for Efficient and Eco-sustainable Ports
Authors: Gattuso Domenico , Pellicanò Domenica Savia , Cassone Gian Carla 
Published: November 2023

IntroductionThe port system is one of the main sources of national and international trade; it is essential for the transfer of freight and people, but at the same time it is a critical site in relation to energy consumption and greenhouse gas emissions. For this reason, some management strategies are developed to optimize the freight terminal activities using innovative technologies to limit the negative environmental impacts.ObjectiveThis study focuses specifically on vehicle management on the landside of a container port and aims to evaluate the impacts and performance of the system, in which the traditional handling units are replaced by green and automated ones. The study is part of a framework of actions to be undertaken to pursue the target “to make a port more competitive and sustainable”.MethodsThis study deals with the assessment of the handling time, energy consumption, and gas emission deriving from the innovative vehicular technologies capable of making the port more competitive and sustainable. A modeling approach is used to understand the possible impacts generated by new technologies on port performance. The models have been calibrated on the basis of a large database carried out by a specific survey of port operators and specialized companies.ResultsA case study is proposed about the container port of Gioia Tauro (Italy), an important port in the center of the Mediterranean area in terms of transshipment. Some specific indicators are analyzed by quantitative models, such as energy consumption for efficiency and harmful gases for ecology, considering the current port configuration and some project scenarios in which green and automated handling units are used. The analysis has been performed using a spreadsheet, with automatic calculation. The input data related to the actual port configuration have been provided by the port management company; those related to the scenarios have been taken from specialized companies. Data included refer to the last 5 years.ConclusionThe study highlights the advantages of green and automated handling means; the use of these solutions represents a fundamental step to making a port more competitive and sustainable. This research could stimulate policymakers and port managers towards innovative technological solutions to make a port more competitive and sustainable. The proposed approach can be applied and extended to other contexts.
Gum-based Nanoparticles Targeting for Colon Rectal Cancer: Latest
Research and Patents
Authors: Shakya Shilpi , Tiwari Ritesh Kumar , Gupta Arti 
Published: November 2023

Abstract:
Colorectal disease is the third most prevelant cancer in both men and women, with an
expected 106,180 new cases of colon cancer and 44,850 new cases of rectal cancer as per American
Cancer Society. Targeted medicine delivery is vital in the treatment of colon disorders because it
delivers long-term therapeutic results with little side effects. Natural polymer is biocompatible and
biodegradable, which enables safety, improves storage, and physiological stability, it is utilized as
drug delivery vehicles and has made great strides in recent years. Chitosan, alginate, pectin, guar
gum, dextran, hyaluronic acid, and arabinoxylan are examples of natural polysaccharides that are
utilized to create nanoparticles. Natural gums serve two purposes: first, they shield the medicine
from stomach and intestinal conditions, allowing it to only be released in the colon. In this review,
we introduce the different gum particularly used in nanoparticles formulation, and then discuss recent
research and the latest patent in the development of gum-based nanoparticles for the treatment
of colon rectal cancer.
Zirconium Dioxide Nanoparticles Effect on the Color Stability of Maxillofacial Silicone after Outdoor Weathering
Authors: Abdalqadir Mohammed , Azhdar Bruska 
Published: November 2023

Background:
Maxillofacial prostheses made of silicone elastomers tend to lose color. Despite advances in materials and processes, color change over time remains a challenge.

Objective:
This in vitro study aimed to observe how zirconium dioxide (ZrO2) nanoparticles impact the color stability of M511 heat temperature vulcanizing (HTV) silicone elastomer following outdoor weathering.

Methods:
ZrO2 nanoparticles were added in concentrations of 1%, 2%, and 3% by weight to the M511 HTV silicone elastomer. Brilliant red- and mocha-pigmented silicone pigments were utilized, along with colorless silicone as a base control. A total of 90 disk-shaped specimens were fabricated and divided into nine experimental groups, each containing ten samples (n = 10). All specimens were subjected to 6 months of outdoor weathering. A colorimeter was used to measure the values of L*a*b* according to the CIELab system. The 50:50% perceptibility threshold (∆E* = 1.1) and acceptability threshold (∆E* = 3.0) were used to interpret recorded color differences. At the 0.05 level of significance, the 1-way ANOVA and the Tukey post hoc test were used in the statistical analysis.

Results:
All evaluated specimen groups experienced a chromatic alteration (∆E* > 0). The ∆E* values exceeded the perceptible threshold in all groups (1.1 units). The ∆E* value of the colorless group and the red pigment with and without ZrO2 nanoparticles were both above the acceptable threshold (p < 0.001). Mocha control was also above the acceptable level but was not statistically significant (p > 0.99). ZrO2 nanoparticles showed a reduction in color change.

Conclusion:
According to this in vitro study, all specimens underwent color changes. Even colorless silicone exhibited a significant color change. The red pigment showed a highly significant chromatic alteration. ZrO2 nanoparticles showed important protection and a reduction in color change. Its protecting action increased with an increase in the concentration of ZrO2 nanoparticles (3% ZrO2 > 2% ZrO2 > 1% ZrO2).
Implementasi Kontrol Nutrisi Dan pH Pada Hidroponik Cerdas Berbasis Arduino Dan JST
Authors: Zul Hazmi Muhammad Naufal , Sumiharto Raden 
Published: November 2023

This research aims to implement an automated nutrition and pH control system in NFT hydroponic system based on ANN control. NFT hydroponics involves growing plants without soil as a medium. In hydroponics, it is essential to continuously control the nutrient levels and pH of the solution. However, manual control performed by humans continuously is inefficient and time-consuming.The ANN method is used to model and predict the output actuators based on sensor input in the NFT hydroponic system. This ANN architecture consists of several layers with the following number of neurons: input layer 2, first hidden layer 128, second hidden layer 64, and output layer 3, representing multipleoutputs. The ANN training process involves classifying the data samples using various hyperparameters.The research findings demonstrate the ANN classification model successfully applied to control pH and nutrient levels through the predicted output actuators. The pump actuators are activated according to input received from the TDS and pH sensors. Through the variation of hyperparameters, the classification model with a test_size: 0.3, epoch: 400, batch_size: 32, and random_state: 42 provided the best performance in prediction. This ANN classification model achieved the best results in model testing with an accuracy rate: 97.96% from 49 data.
Peningkatan Hasil Belajar Biologi Siswa dengan Model STAD Pada Konsep Jaringan Tumbuhan
Authors: Fitri Yusri Rahmi , Siti Nurhalijah Siti Nurhalijah , Pricillia Humaira Pricillia Humaira , Putri Fatmaya Putri Fatmaya , Suci Novany Suci Novany , Annisa Purba Annisa Purba 
Published: November 2023

In a teaching and learning process, apart from the teacher, there are two very important elements, namely teaching methods and learning media. Learning has several models or learning approaches, one of which is cooperative learning. Cooperative learning is a learning approach that focuses on using small groups of students to work together and maximize learning conditions to achieve learning objectives. Student teams achievement division (STAD) learning is a type of cooperative learning that emphasizes interaction between students to motivate each other and help each other in mastering the material and achieving maximum achievement. This study aims to determine the improvement of students' biology learning outcomes with the stad type cooperative learning model on the concept of plant tissue. This research method is literature review. Literature review is a literature search and research by reading various books, journals, and other publications related to the research topic, to produce an article related to a particular topic. Based on the above discussion, it is concluded that the use of the STAD type cooperative learning model has a significant effect on improving student biology learning outcomes on the concept of plant tissue.
Key words: Education, Learning, Cooperative, and STAD

ABSTRAK
Proses belajar mengajar, selain guru ada dua unsur yang amat penting yaitu metode mengajar dan media pembelajaran. Pembelajaran memiliki beberapa model atau pendekatan pembelajaran, salah satunya adalah pembelajaran kooperatif. Pembelajaran kooperatif merupakan suatu pendekatan pembelajaran yang berfokus pada penggunaan kelompok kecil siswa untuk bekerja sama dan memaksimalkan kondisi belajar untuk mencapai tujuan belajar. Pembelajaran student teams achievement division (STAD) merupakan salah satu tipe pembelajaran kooperatif yang menekankan interaksi diantara siswa untuk saling memotivasi dan saling membantu dalam menguasai materi dan mencapai prestasi secara maksimal. Penelitian kali ini bertujuan untuk mengetahui peningkatan hasil belajar biologi siswa dengan model pembelajaran kooperatif tipe stad pada konsep jaringan tumbuhan. Metode penelitian ini adalah literature review. Literature review adalah suatu penelusuran dan penelitian kepustakaan dengan membaca berbagai buku, jurnal, dan terbitan-terbitan lain yang berikaitan dengan topik penelitian, untuk menghasilkan suatu tulisan yang berkenaan dengan suatu topik tertentu. Berdasarkan pembahasan diatas, disimpulkan bahwa penggunaan model pembelajaran kooperatif tipe STAD berpengaruh signifikan terhadap peningkatan hasil belajar biologi siswa pada konsep jaringan tumbuhan.
Kata kunci: Pendidikan, Pembelajaran, Koopertaif, STAD
Media Pembelajaran Berbantuan Aplikasi Multimedia Interaktif pada Materi Pencemaran Lingkungan
Authors: Ilham Syarif Muhammad , Dahlia Meirisa , Ilhami Aldeva , Safrizal Safrizal 
Published: November 2023

As technology and information advances so rapidly, technology has driven developments in the world of education. This can be seen from the use of various learning media and also the tools used in the learning process are increasingly advanced and sophisticated, the world of education is also increasingly advanced along with technological advances. The purpose of this study is to find out the evaluation of the products that have been produced by researchers and the benefits of this research are so that researchers can find out what needs to be improved from the multimedia they have produced. This research is an R&D model multimedia development research at SMP 23 Pekanbaru for the implementation of this multimedia. Data collection was taken from a field survey conducted. From the results of the survey data it is known that interactive multimedia on environmental pollution material is very effective and very good to use. So it can be concluded that this interactive multimedia can be used in the learning process in environmental pollution material for grade 7 junior high school students
Abstrak. Seiring kemajuan teknologi dan informasi yang begitu pesat, teknologi telah mendorong perkembangan dalam dunia pendidikan. Hal tersebut dapat terlihat dari digunakannya beragam media pembelajaran dan juga alat -alat yang digunakan dalam proses pembelajaran semakin maju dan canggih dunia pendidikan pun semakin maju seiring kemajuan teknologi. Tujuan dari penelitian ini yaitu untuk mengetahui penilaian dari produk yang telah dihasilkan oleh peneliti dan manfaat dari penelitian ini adalah agar peneliti dapat mengetahui apa saja yang perlu diperbaiki dari multimedia yang telah dihasilkannya. Penelitian ini merupakan penelitian pengembangan multimedia model R&D pada SMP 23 Pekanbaru untuk implementasi multimedia ini. Pengambilan data diambil dari survey lapangan yang dilakukan. Dari hasil data survey diketahui bahwa multimedia interaktif pada materi pencemaran lingkungan sangat efektif dan sangat bagus digunakan. Sehingga dapat disimpulkan bahwa multimedia interaktif ini dapat digunakan pada proses pembelajaran dalam materi pencemaran lingkungan untuk siswa SMP kelas 7
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Project Based Learning (PjBL) Pada Matei Pencemaran Lingkungan Untuk Kelas X SMA
Authors: Febriyanti Tiur , Hakim Nasrul 
Published: November 2023

The development of student worksheets (LKPD) based on Project Based Learning (PjBL) on environmental pollution material is motivated by the less varied and innovative learning media used. The media used were only in the form of PowerPoint and printed books from the library, as a result, students agreed if learning media were developed in the form of Project Based Learning (PjBL) student worksheets. This study applies the R&D (Reseach and Development) development method using the ADDIE development model steps. The results of PjBL-based LKPD product validation were declared "very feasible" by the material expert validator with a percentage of 90% and the media expert validator with a percentage of 83%. The results of the PjBL-based worksheet product trial responses that had been developed for biology subject teachers were declared "good" with a percentage of 82% and trials for students were declared "very good" with a percentage of 94.8%. This can be interpreted that the LKPD media that has been developed is very suitable to be used as an alternative learning media that can be used in the learning process in class. Furthermore, the PjBL Project Based Learning LKPD learning media on environmental pollution material can be used outside of school learning and with the implementation of Project Based Learning it is able to hone the creativity of students.
Abstrak. Pengembangan Lembar Kerja Peserta Didik (LKPD) berbasis Project Based Learning (PjBL) pada materi pencemaran lingkungan dilatarbelakangi oleh media pembelajaran yang digunakan kurang bervariasi dan inovatif. Media yang digunakan hanya berupa powerpoint dan buku cetak dari perpustakaan, akibatnya, siswa setuju jika dikembangkan media pembelajaran berupa lembar kerja peserta didik berbasis Project Based Learning (PjBL). Penelitian ini menerapkan metode pengembangan R&D (Reaseach and Development) dengan menggunakan langkah-langkah model pengembangan ADDIE. Hasil validasi produk LKPD berbasis PjBL dinyatakan “sangat layak” oleh validator ahli materi dengan persentase 90% dan validator ahli media dengan persentase 83%. Hasil respon uji coba produk LKPD berbasis PjBL yang telah dikembangkan kepada guru mata pelajaran biologi dinyatakan “baik” dengan persentase 82% dan uji coba kepada peserta didik dinyatakan “sangat baik” dengan persentase 94,8%. Hal ini dapat diartikan bahwa media LKPD yang telah dikembangkan sangat layak dijadikan sebagai media pembelajaran altenatif yang mampu digunakan dalam proses pembelajaran dikelas. Selanjutnya, media pembelajaran LKPD berbasis Project Based Learning PjBL pada materi pencemaran lingkungan mampu digunakan di luar pembelajaran disekolah dan dengan diterapkanya Project Based Learning mampu mengasah kreatifitas peserta didik.
Pengaruh Model Discovery Learning Dipadu Lesson Study terhadap Hasil Belajar Mahasiswa Pendidikan Biologi
Authors: Mardiyanti Lely 
Published: November 2023

Combining the learning model with lesson study (LS) can increase the effect of the model in achieving the desired learning outcomes. The purpose of this pre-experimental research is to determine the effect of the discovery learning model combined with LS on the learning outcomes of Biology Education Students. This research was conducted for 1 semester on 30 students who took Plant Physiology Course in the Undergraduated Program of Biology Education, Universitas Negeri Malang using one-group pretest–posttest design. Data on learning outcomes were obtained through essay tests (pretest and posttest) and analyzed using paired t tests. The results of the paired t test inform that there is a big difference in student learning outcomes before (M = 37.5, SD = 13.3) and after learning using the discovery learning model combined with LS (M = 77, SD = 13), t(29) = 18.2, p < 0.001, d = 3.3. Thus, the application of the discovery learning model combined with LS has a major effect on the learning outcomes of Biology Education students in Plant Physiology Course.
Key words: Discovery Learning, Lesson Study, and Learning Outcomes

Abstrak
Memadukan model pembelajaran dengan lesson study (LS) dapat meningkatkan pengaruh model dalam mencapai hasil belajar yang diinginkan. Tujuan dari penelitian pre-eksperimental ini yaitu mengetahui pengaruh model discovery learning dipadu LS terhadap hasil belajar Mahasiswa Pendidikan Biologi. Penelitian ini dilakukan selama 1 semeter pada 30 mahasiswa yang menempuh Mata Kuliah Fisiologi Tumbuhan di Program Studi S-1 Pendidikan Biologi, Universitas Negeri Malang menggunakan one-group pretest–posttest design. Data hasil belajar diperoleh melalui tes esai (pretes dan postes) dan dianalisis menggunakan uji t berpasangan. Hasil uji t berpasangan menginformasikan bahwa terdapat perbedaan besar pada hasil belajar siswa sebelum sebelum (M = 37,5, SD = 13,3) dan setelah pembelajaran menggunakan model discovery learning dipadu LS (M =77, SD = 13), t(29) = 18,2, p < 0,001, d = 3,3. Sehingga, penerapan model discovery learning dipadu LS memiliki pengaruh besar terhadap hasil belajar mahasiswa Pendidikan Biologi pada Mata Kuliah Fisiologi Tumbuhan.
Kata kunci: Discovery Learning, Lesson Study, dan Hasil Belajar
The Relationship between Gadget Abuse and Student Learning Motivation at SMP Negeri 25 Padang
Authors: Ibna Resti Hidayatul , Ardi Zadrian 
Published: November 2023

The development of an increasingly sophisticated era, especially in the field of technology, one of which is gadgets, so that it can have positive and negative impacts on its users. One of the negative impacts is the excessive use of gadgets on students, in their use students are not able to limit them so that it causes a decrease in student motivation in learning. This study aims: (1) to describe gadget abuse among students, (2) to describe student learning motivation, and (3) to examine the relationship between gadget abuse and junior high school students' learning motivation. This study uses a quantitative approach with a correlational type. The subjects of this study were 263 students using the Simple Random Sampling technique. The instrument used was a questionnaire using a Likert scale. Data were analyzed using descriptive statistical techniques and to examine the relationship between gadget misuse and learning motivation, the Pearson product moment correlation technique was used. The results showed that: (1) gadget abuse is generally in the high category, (2) learning motivation is in the medium category, and (3) there is a negative relationship between gadget abuse and student motivation with a correlation coefficient of -0.346 and a significance level 0.001. Based on the results of the research, it is expected that counseling teachers can provide assistance in the form of information guidance services, group guidance services, so that they are able to increase learning motivation well.