bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disulfidptosis-related prognostic signature correlates with immunotherapy response in colorectal cancer
Authors: Xiao Yu , Lin Hancui , Li Jinluan , Wu Junxin 
Published: January 2024

AbstractDisulfidptosis (DSP), a form of cell death caused by disulphide stress, plays an important role in tumour progression. However, the mechanisms by which DSP regulates the tumour microenvironment remain unclear. Thus, we analysed the transcriptome profiles and clinical data, which were obtained from the TCGA database, of 540 patients with colorectal cancer. Compared with the patients with low DSP expression, those with high DSP expression exhibited significantly better survival outcomes; lower stromal and ESTIMATE scores; significantly higher numbers of CD4+ T cells, M2 macrophages, dendritic cells, and neutrophils; higher expression of immune checkpoint-related genes; and lower Tregs and HLA-DQB2 levels. A prognostic signature established based on DSP-related genes demonstrated an increase in risk score with a higher clinical stage. Risk scores negatively correlated with dendritic cells, eosinophils, and CD4+ T cells and significantly positively correlated with Treg cells. Patients with higher risk scores experienced significantly worse survival outcomes and immunotherapy non-response. Our nomogram model, combining clinicopathological features and risk scores, exhibited robust prognostic and predictive power. In conclusion, DSP-related genes actively participated in regulating the tumour microenvironment. Thus, they can serve as biomarkers to provide targeted treatment for colorectal cancer.
Antiferromagnetic interlayer exchange coupled Co68B32/Ir/Pt multilayers
Authors: Darwin Emily , Tomasello Riccardo , Shepley Philippa M. , Satchell Nathan , Carpentieri Mario , Finocchio Giovanni , Hickey B. J. 
Published: January 2024

AbstractSynthetic antiferromagnetic structures can exhibit the advantages of high velocity similarly to antiferromagnets with the additional benefit of being imaged and read-out through techniques applied to ferromagnets. Here, we explore the potential and limits of synthetic antiferromagnets to uncover ways to harness their valuable properties for applications. Two synthetic antiferromagnetic systems have been engineered and systematically investigated to provide an informed basis for creating devices with maximum potential for data storage, logic devices, and skyrmion racetrack memories. The two systems considered are (system 1) CoB/Ir/Pt of N repetitions with Ir inducing the negative coupling between the ferromagnetic layers and (system 2) two ferromagnetically coupled multilayers of CoB/Ir/Pt, coupled together antiferromagnetically with an Ir layer. From the hysteresis, it is found that system 1 shows stable antiferromagnetic interlayer exchange coupling between each magnetic layer up to N = 7. Using Kerr imaging, the two ferromagnetic multilayers in system 2 are shown to undergo separate maze-like switches during hysteresis. Both systems are also studied as a function of temperature and show different behaviors. Micromagnetic simulations predict that in both systems the skyrmion Hall angle is suppressed with the skyrmion velocity five times higher in system 1 than system 2.
LC–MS profiling, in vitro and in silico C-ABL kinase inhibitory approach to identify potential anticancer agents from Dalbergia sissoo leaves
Authors: Naik Hem N. , Kanjariya Dilip , Parveen Shahnaz , Ahmed Iqrar , Meena Abha , Patel Harun , Meena Ramavatar , Jauhari Smita 
Published: January 2024

AbstractBelonging to the Fabaceae family, Dalbergia sissoo, a versatile plant, has gained prominence for its potent medicinal attributes, especially antipyretic, anti-inflammatory, and cardioprotective properties, as well as the use of its leaf juice in cancer treatment. Despite these recognized applications by natives and tribals, comprehensive insight into its biological activities and chemical composition remains limited. This study aimed to explore the cytotoxic potential of sequentially extracted leaf extracts from Dalbergia sissoo using various solvents, aiming to unveil the array of phytochemicals through LC–MS profiling. Among the extracts evaluated, the extract employing methanol:water extracting media (HN-2) appeared with the most remarkable results in both phytochemical diversity and biological activity. Furthermore, in vitro results of HN-2's in vitro anticancer efficacy were confirmed through in silico molecular docking and molecular dynamics simulation. These analyses demonstrated its ability to inhibit C-ABL kinase within leukemia K562 cells, directing that Dalbergia sissoo leaves serve as a bioactive agent reservoir. Consequently, this suggests that the Dalbergia sissoo plant is a potential source of bioactive compounds that can be used as a precursor for developing new cancer inhibitors, mainly targeting leukemia.
Comparison between methods for determining the effective vertical yield stress of intermediate fine-grained soils
Authors: Olek Bartłomiej Szczepan , Moskal Magdalena 
Published: January 2024

AbstractEffective vertical yield stress (σ′xy) is essential in accurately describing fine-grained soils’ mechanical properties and their behaviour under load over time. It helps assess settlements and stress history. In most constitutive models, this parameter indicates changes in the soil behaviour due to the development of recoverable and irrecoverable strains resulting from loading. The results of oedometric compression tests for 25 soil samples with a wide range of plasticity parameters were used for the investigation. The intermediate fine-grained soils comprised different proportions of clayey, silty and sandy fractions. An in-depth, two-staged statistical analysis was carried out to compare twelve methods of determining effective vertical yield stress, namely: Casagrande (CM), Pacheco Silva (PSM), Butterfield (BTM), Oikawa (OIM), Onitsuka (ONM), Boone (BM), Becker (WM), Morin (WPUVSM) Wang & Frost (DSEM), Tavenas (SEM), Senol (SLSEM), and Janbu (JM). It aimed to check the association of these methods and the consistency of the obtained results. Based on the difference analysis, the methods originated in the work approach (i.e. WM, WPUVSM, DSEM) and CM gave comparable σ′xy values. The methods utilised bi-logarithmic plots (i.e. BTM, OIM, ONM) received slightly greater or lesser σ′xy values than BM and JM. The remaining methods were characterised by medium to the high variability and were sensitive to even the slightest disturbances resulting from the procedure of determining σ′xy.
Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab
Authors: Dallari Simone , Martinez Pazos Vicky , Munoz Eusse Juan , Wellens Judith , Thompson Craig , Colombel Jean-Frederic , Satsangi Jack , Cadwell Ken , Wong Serre-Yu ,   ICARUS-IBD Working Group, Neil Jessica Anne , Sota Stela , Jang Kyung Ku , Ching Krystal , Venzon Mericien , Yao Xiaomin , Bernard Lucie , Chen Xin , Tankelevich Michael , Navalurkar Reema , Dixon Rebekah , Helmus Drew S. , Lange Marcia Mukanga , Spiera Emily , Sangmo Lodoe 
Published: January 2024

AbstractWhile differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID-19 vaccine development, we screened 235 patients with IBD receiving biological therapy for antibodies to SARS-CoV-2 and measured serum cytokines. In seropositive patients, we prospectively collected clinical data. We found a cytokine signature in patients receiving vedolizumab who are seropositive compared with seronegative for SARS-CoV-2 antibodies that may be linked to repeated SARS-CoV-2 infections. However, there were no differences between seropositive and seronegative patients receiving infliximab. In this single-center cohort of patients with IBD with anti-SARS-CoV-2 antibodies at the onset of the COVID-19 pandemic, and therefore without influence of vaccination, there is a cytokine signature in patients receiving vedolizumab but not infliximab. These findings lay the groundwork for further studies on immune consequences of viral infection in patients with IBD, which is postulated to evolve from aberrant host-microbe responses.
Comparison between ammonium formate and ammonium fluoride in the analysis of stratum corneum lipids by reversed phase chromatography coupled with high resolution mass spectrometry
Authors: Maiellaro Miriam , Bottillo Grazia , Cavallo Alessia , Camera Emanuela 
Published: January 2024

AbstractLipids are key constituents of the barrier function in the human stratum corneum (SC), which is the outermost layer of the epidermis and amenable to non-invasive sampling by tape stripping. The three major lipid classes in the SC, i.e., ceramides, fatty acids, and cholesterol, present equimolar concentration. Liquid chromatography coupled with mass spectrometry (LCMS) is elective in profiling lipids in the SC in both positive and negative ion modes. Nevertheless, the latter one allows for the simultaneous detection of the three major epidermal components of the SC. Determination of ceramides in the SC poses analytical challenges due to their wide range of structures and concentrations especially in the case of limited sample amounts. Ammonium formate is a commonly used modifier added to the mobile phase to assist ionization. However, it introduces uncertainty in the identification of ceramides when operating in negative ion mode, even with high resolution MS. We tested the advantages of using fluoride in the lipid profiling of SC and unambiguous identification of ceramides subclasses. The use of fluoride enhanced the ionization of ceramides, regardless the specific substructure, solved misidentification issues, and was successfully applied to the simultaneous detection of all three lipid classes in the human SC.
Tactics analysis and evaluation of women football team based on convolutional neural network
Authors: Shen Lechuan , Tan Zhongquan , Li Zekun , Li Qikun , Jiang Guoqin 
Published: January 2024

AbstractIn order to realize the process of player feature extraction and classification from multi-frequency frame-changing football match images more quickly, and complete the tactical plan that is more conducive to the game, this paper puts forward a method for analyzing and judging the tactics of women’s football team based on Convolutional Neural Network (CNN). By extracting the players’ performance in recent training and competition from continuous video frame data, a multi-dimensional vector input data sample is formed, and CNN is used to analyze the players’ hidden ability before the game and the players’ mistakes in different positions on the field to cope with different football schedules. Before the formal test, 10 games of 2021–2022 UEFA Women’s Champions League were randomly selected and intercepted to train the CNN model. The model showed excellent accuracy in the classification of image features of various football moves and goal angles, and the overall classification accuracy of each category exceeded 95%. The accuracy of classifying a single match is above 88%, which highlights the reliability and stability of the model in identifying and classifying women’s football matches. On this basis, the test results show that: according to the analysis of players’ personal recessive ability before the game, after model image recognition and comparison, the difference between the four scores of players’ personal recessive ability with CNN mode and the manual score of professional coaches was smaller, and the numerical difference was within the minimum unit value, and the numerical calculation results were basically the same. According to the analysis of players’ mistakes in different positions on the field, CNN was used to monitor the real-time mistakes. It was found that the two players in the forward position made the highest mistakes, and they were replaced by substitute players at 73.44 min and 65.28 min after the team scored and kept the ball, respectively. After the substitute players played, the team’s forward position mistake rate decreased obviously. The above results show that CNN technology can help players get personal recessive ability evaluation closer to professional evaluation in a shorter time, and help the coaching team to analyze the real-time events better. The purpose of this paper is to help the women’s football team complete the pre-match tactical training, reduce the analysis time of players’ mistakes in the game, deal with different opponents in the game and improve the winning rate of the game.
Excitation of optical tamm state for photonic spin hall enhancement
Authors: Goyal Amit Kumar , Divyanshu Divyanshu , Massoud Yehia 
Published: January 2024

AbstractThis work presents a dielectric material-based optical Tamm state (OTS) excitation technique with modified dispersion characteristics for photonic spin hall effect (PSHE) enhancement. The dispersion analysis of the structure is carried out to validate OTS’s localization and corresponding PSHE generation for a given polarization at 632.8 nm incident wavelength. The exceptional points are optimized by considering thickness-dependent angular dispersion analysis. PSHE-based transverse displacement (PSHE-TD) is dependent on the defect layer thickness. The optimized structure provides 10.73 $$\times \lambda$$

×
λ

(or 6.78 $$\upmu$$
μ
m) PSHE-TD at an incidence angle of 41.86$${}^{\circ }$$

∘

. The PSHE-TD of the optimized structure is sufficiently high due to the much narrower resonance than the plasmonic-based structures. Further, the structure’s potential to function as a PSHE-TD-based optical sensor is assessed. The optimized structure shows an analytical average sensitivity of about 43,789 $$\upmu$$
μ
m/RIU showing its capability to detect the analytes with refractive index variations in the $$10^{-4}$$

10

-
4

range. The structure demonstrates a three-time sensitivity improvement compared to similar resonance designs. Considering only dielectric materials in the proposed structure and considerably enhanced PSHE-TD, the development of highly efficient PSHE-TD-assisted commercial structures is anticipated.
Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart
Authors: Dial Michael B. , Malek Elias M. , Neblina Greco A. , Cooper Austin R. , Vaslieva Nikoleta I. , Frommer Rebecca , Girgis Magdy , Dawn Buddhadeb , McGinnis Graham R. 
Published: January 2024

AbstractCircadian rhythms play a crucial role in the regulation of various physiological processes, including cardiovascular function and metabolism. Exercise provokes numerous beneficial adaptations in heart, including physiological hypertrophy, and serves to shift circadian rhythms. This study investigated the impact of time-restricted exercise training on exercise-induced adaptations in the heart and locomotor activity rhythms. Male mice (n = 45) were allocated to perform voluntary, time-restricted exercise in the early active phase (EAP), late active phase (LAP), or remain sedentary (SED) for 6 weeks. Subsequently, mice were allowed 24-h ad libitum access to the running wheel to assess diurnal rhythms in locomotor activity. Heart weight and cross-sectional area were measured at sacrifice, and cardiac protein and gene expression levels were assessed for markers of mitochondrial abundance and circadian clock gene expression. Mice rapidly adapted to wheel running, with EAP mice exhibiting a significantly greater running distance compared to LAP mice. Time-restricted exercise induced a shift in voluntary wheel activity during the 24-h free access period, with the acrophase in activity being significantly earlier in EAP mice compared to LAP mice. Gene expression analysis revealed a higher expression of Per1 in LAP mice. EAP exercise elicited greater cardiac hypertrophy compared to LAP exercise. These findings suggest that the timing of exercise affects myocardial adaptations, with exercise in the early active phase inducing hypertrophy in the heart. Understanding the time-of-day dependent response to exercise in the heart may have implications for optimizing exercise interventions for cardiovascular health.
The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index
Authors: Rasaei Niloufar , Gholami Fatemeh , Samadi Mahsa , Shiraseb Farideh , Khadem Alireza , Yekaninejad Mir Saeed , Emamgholipour Solaleh , Mirzaei Khadijeh 
Published: January 2024

AbstractWe aimed to investigate the interaction between the transcript levels of taurine-upregulated gene 1 (TUG1) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the Cholesterol-Saturated Fat Index (CSI) in relation to the visceral adiposity index (VAI) and body adiposity index (BAI). This cross-sectional study involved 346 women classified as obese and overweight, aged between 18 and 48 years. Dietary intake and the quality of dietary fat were assessed using a validated and reliable 147-item semi-quantitative food frequency questionnaire, with the Cholesterol-Saturated Fat Index (CSI) used as an indicator. Transcription levels of MALAT1 and TUG1 were evaluated through real-time polymerase chain reaction following the criteria outlined in the Minimum Information for Publication of Quantitative standards. Serum profiles were measured using standard protocols. We observed a positive association between transcription level of MALAT1 and VAI in both crude (β = 3.646, 95% CI 1.950–5.341, p < 0.001) and adjusted (β = 8.338, 95% CI 6.110–10.566, p < 0.001) models. Furthermore, after adjusting for confounders, a significant positive interaction was noted between MALAT1 expression and CSI on BAI (β: 0.130, 95% CI 0.019, 0.240, p = 0.022), with a marginal positive interaction observed on VAI (β: 0.718, 95% CI − 0.028, 1.463, p = 0.059). It seems that there may be a positive interaction between MALAT1 transcription level and CSI on VAI and BAI among overweight and obese women. However, no associations were seen between TUG1 mRNA level and the above-mentioned outcomes. Further functional studies are still required to elucidate this concept.
Modeling sunset yellow removal from fruit juice samples by a novel chitosan-nickel ferrite nano sorbent
Authors: Shokri Samira , Shariatifar Nabi , Molaee-Aghaee Ebrahim , Jahed Khaniki Gholamreza , Sadighara Parisa , Faramarzi Mohammad Ali 
Published: January 2024

AbstractAnalysis of food additives is highly significant in the food industry and directly related to human health. This investigation into the removal efficiency of sunset yellow as an azo dye in fruit juices using Chitosan-nickel ferrite nanoparticles (Cs@NiFe2O4 NPs). The nanoparticles were synthesized and characterized using various techniques. The effective parameters for removing sunset yellow were optimized using the response surface methodology (RSM) based on the central composite design (CCD). Under the optimum conditions, the highest removal efficiency (94.90%) was obtained for the initial dye concentration of 26.48 mg L−1 at a pH of 3.87, a reaction time of 67.62 min, and a nanoparticle dose of 0.038 g L−1. The pseudo-second-order kinetic model had a better fit for experimental data (R2 = 0.98) than the other kinetic models. The equilibrium adsorption process followed the Freundlich isotherm model with a maximum adsorption capacity of 212.766 mg g−1. The dye removal efficiency achieved for industrial and traditional fruit juice samples (91.75% and 93.24%), respectively, confirmed the method's performance, feasibility, and efficiency. The dye adsorption efficiency showed no significant decrease after five recycling, indicating that the sorbent has suitable stability in practical applications. variousThe synthesized nanoparticles can be suggested as an efficient sorbent to remove the sunset yellow dye from food products.
Earliest known funerary rites in Wallacea after the last glacial maximum
Authors: Hawkins Stuart , Zetika Gabriella Ayang , Kinaston Rebecca , Firmando Yulio Ray , Sari Devi Mustika , Suniarti Yuni , Lucas Mary , Roberts Patrick , Reepmeyer Christian , Maloney Tim , Kealy Shimona , Stirling Claudine , Reid Malcolm , Barr David , Kleffmann Torsten , Kumar Abhishek , Yuwono Pratiwi , Litster Mirani , Husni Muhammad , Ririmasse Marlon , Mahirta  , Mujabuddawat Muhammad , Harriyadi  , O’Connor Sue 
Published: January 2024

AbstractThe insular region of Wallacea has become a focal point for studying Pleistocene human ecological and cultural adaptations in island environments, however, little is understood about early burial traditions during the Pleistocene. Here we investigate maritime interactions and burial practices at Ratu Mali 2, an elevated coastal cave site on the small island of Kisar in the Lesser Sunda Islands of eastern Indonesia dated to 15,500–3700 cal. BP. This multidisciplinary study demonstrates extreme marine dietary adaptations, engagement with an extensive exchange network across open seas, and early mortuary practices. A flexed male and a female, interred in a single grave with abundant shellfish and obsidian at Ratu Mali 2 by 14.7 ka are the oldest known human burials in Wallacea with established funerary rites. These findings highlight the impressive flexibility of our species in marginal environments and provide insight into the earliest known ritualised treatment of the dead in Wallacea.
Rigid-foldable cylindrical origami with tunable mechanical behaviors
Authors: Liu Fengrui , Terakawa Tatsuro , Long Siying , Komori Masaharu 
Published: January 2024

AbstractRigid-foldable origami shows significant promise in advanced engineering applications including deployable structures, aerospace engineering, and robotics. It undergoes deformation solely at the creases during the folding process while maintaining rigidity throughout all facets. However, most types of cylindrical origami, such as Kresling origami, water-bomb origami, and twisted tower origami, lack rigid-foldability. Although shape transformation can be achieved through elastic folding, their limited rigid foldability constrains their engineering applications. To address this limitation, we proposed a type of cylindrical origami inspired by Kresling origami, named foldable prism origami (FP-ori), in this paper. FP-ori possesses not only rigid-foldability but also several tunable properties, including flat-foldability, self-locking, and bistability. The geometric properties of FP-ori were analyzed and the relationship between different parameters and tunable mechanical behaviors were verified through finite element method simulations, as well as experiments using paper models. Furthermore, we proposed stacked structures composed of multiple cubic FP-ori units, the rotation directions of which could be controlled through the combination arrangement. And drawing inspiration from kirigami, a negative Poisson’s ratio tessellation structure was created. These results indicated that FP-ori has substantial potential for broad application in engineering fields.