bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penentuan Daerah Rawan Polusi Udara dengan Menggunakan Logika Fuzzy Metode Mamdani
Authors: Atalla Muhammad Naufal , Lukman Lukman , Agustina Fitriani 
Published: October 2023

The purpose of this research is to determine whether an area in the Bandung city is categorized as an area prone to air pollution or not, which is illustrated in the form of a thematic map. In this study, Fuzzy Inference System (FIS) is used with the Mamdani method. The parameters determining the vulnerability used among others are PM10 concentration, SO2 concentration, and rainfall. In this study, 89 data were used. The results showed that the city of Bandung is categorized as an area not prone to air pollution with an average vulnerability value of 17,235. However, in March there were areas categorized as air pollution-prone namely Regol, Lengkong, Kidul, Buahbatu, Rancasari, and Gedebage Districts with a vulnerability value of 47.5. Based on the results of this study, it is hoped that people will be aware of the air conditions in the environment where they live and realize the importance of maintaining air quality.Keywords: Air Pollution, Fuzzy Logic, Geographic Information System, Mamdani Method, Thematic Map. AbstrakPenelitian ini bertujuan agar masyarakat menyadari kondisi udara di lingkungan tempat mereka hidup dan menyadari pentingnya menjaga kualitas udara. Fuzzy Inference System (FIS) merupakan sistem yang digunakan dalam pengambilan keputusan dari sejumlah data yang memiliki ketidakpastian fuzzy antara lain dalam Sistem Informasi Geografis (SIG). Dalam penelitian ini FIS digunakan dalam pengambilan keputusan untuk menentukan suatu daerah rawan polusi udara di Kota Bandung yang digambarkan dalam bentuk peta tematik. Parameter-parameter penentu kerawanan yang digunakan antara lain konsentrasi PM10, konsentrasi SO2, dan curah hujan. Metode yang digunakan dalam sistem ini adalah metode Mamdani. Data yang digunakan pada penelitian ini sebanyak 89 data. Secara umum pada peta, dapat dilihat bahwa Kota Bandung dikategorikan sebagai daerah tidak rawan polusi udara dengan nilai kerawanan rata-rata sebesar 17,235. Namun pada Bulan Maret terdapat daerah yang dikategorikan rawan polusi udara yaitu Kecamatan Regol, Lengkong, Bandung Kidul, Buahbatu, Rancasari, dan Gedebage dengan nilai kerawanan sebesar 47,5. Berdasarkan hasil penelitian ini, diharapkan masyarakat menyadari kondisi udara di lingkungan tempat mereka tinggal dan menyadari pentingnya menjaga kualitas udara.
Relationship between the Authentic Leadership and Big Personality Trait of Neuroticism: An Empirical Study
Authors: Baker Jasmine J. 
Published: October 2023

The scope of study that has been done on the significant personality impact of neuroticism on authentic leadership has been relatively minimal. Using a correlational method, this study aims to investigate the relationship between neuroticism's primary personality trait and authentic leadership's components (self-awareness, internalized moral perspective, balanced processing, and relational transparency). The authentic leadership questionnaire (ALQ) is used to examine leaders' personalities and authentic leadership styles. The results of this research showed that there is a negative correlation between neuroticism and all authentic leadership dimensions. This was the key takeaway from the study.
COMPREENDENDO A FORMAÇÃO DE NANOESTRUTURAS EM GELO ASTROFÍSICOS ATRAVÉS DA DINÂMICA MOLECULAR CLÁSSICA
Authors: Silva Priscila Alves da , Oliveira Sergio Pilling Guapyassu de , Amarim Rodrigo Garcia 
Published: October 2023

Astrophysical ices (formed by water, among other molecules) act as a catalyst and a reservoir of carbonaceous species, both of which have major implications for astrobiology. In this work, we studied the formation of astrophysical ice nanostructures found in the interstellar medium, having a sheet of graphene as a catalyst substrate, using the classical molecular dynamics technique to model these astrophysical environments. For this, two systems were designed: the first composed of graphene and and the second composed of graphene, and . Initially, a simulation box was built where the area was delimited by graphene whose height varied from 4, 6, 8 and 10 nm. The molecules were evenly distributed throughout the box. The molecular dynamics technique proved to be a promising tool to understand the phenomenon of adsorption of molecules on the substrate, allowing us to realize that the random distribution of molecules in the system interferes with the geometric structure formed by an ice nanostructure. This study allows us to understand, from the nanometric point of view, the influence of some physical-chemical parameters, regarding the formation of nanostructures of astrophysical ices, such as the number of hydrogen bonds, the initial size of the simulation box, and its density during the freezing process
Protective Effects of Ginger Extract on Oxidative Stress and Steroidogenesis-related Genes in The Ovary of Streptozotocin-induced Diabetic Rats
Authors: Raoufi Mehri Fallah , Farahani Tahereh Mokhlesabadi , Mousavi Sadr Jadidi Elnaz Sadat , Gardeshi Tohid Moradi 
Published: October 2023

Background and Aims: Ginger has anti-oxidant and anti-diabetic properties, but its beneficial effects have not been fully understood on ovarian disorders in diabetic conditions. In the current project, the impact of ginger extract was investigated on oxidative stress and steroidogenesis-related genes in streptozotocin (STZ)-induced female rats.
Materials and Methods: The STZ-induced rats were utilized as a diabetic model and received 200 or 400 mg/kg/day ginger extract for eight weeks. The biochemical factors were measured by standard procedures in this study. Serum levels of insulin and sex hormones were assessed by the enzyme-linked immunosorbent assay (ELISA) technique, and the mRNA expression of target genes was assayed by real-time polymerase chain reaction.
Results: An increase in the levels of glucose, testosterone, and malondialdehyde (MDA) as well as a decrease in the levels of insulin, glutathione peroxidase (GPx), 3β-hydroxysteroid dehydrogenase (3βHSD), steroidogenic acute regulatory protein (StAR), 17β-estradiol, and progesterone was observed in the diabetic rats. Ginger (200 mg/kg) exhibited a significant amelioration in the levels of glucose, testosterone, and MDA. Treatment with 200 mg/kg ginger enhanced the levels of GPx, StAR, and 17β-estradiol. Administration with 400 mg/kg ginger extract also ameliorated the level of glucose, testosterone, MDA, and elevated the level of insulin, GPx, 3βHSD, StAR, 17β-estradiol, and progesterone in the diabetic rats.
Conclusion: The current study suggests ginger extract protects against ovarian damage in STZ-diabetic rats.
Validition of Circulation Systems e-Modules Based Learning Cycle 8E
Authors: Rosiana Yuni , Syafii Wan , Putra Riki Apriyandi , Futra Dedi 
Published: October 2023

<p>This study is aimed for developing an electronic module (e-module) on the material of circulation system based on learning cycle 8e. This type of research and development used the Analysis, Design, Development, Implementation and Evaluation (ADDIE) model. The used research instruments were interview sheets and validation questionnaires. The e-module was validated by three experts and the validated aspects were included aspects of didactic, construction and technical. The obtained data were analyzed quantitatively and described descriptively. The results of the study found that the didactic aspect obtained the highest validity value of 96.15% in the II learning material. While the construction aspect found the highest validity value in learning material III was 95.63%. In the technical aspect, the highest score was obtained in learning material III of 93.75%. Therefore, it can be concluded that the e-module circulation system based on learning cycle 8e has good quality and can be used in learning activities.</p>
Analysis of the dynamics of the prevalence of tobacco smoking and the incidence of malignant neoplasms in the Russian Federation in 2011–2021
Authors: Salagay O. O. , Sakharova G. M. , Antonov N. S. , Shakhzadova A. O. 
Published: October 2023

Tobacco is an important risk factor for malignant neoplasms (MN). The article provides an analysis of the incidence of MN for 2011–2021 in the Russian Federation among men and women with different levels of tobacco smoking. Materials and methods. The analysis includes the incidence of cancer of the trachea, bronchi and lung (TBLC), laryngeal cancer (LC) (tobacco is a high risk factor), liver cancer (a low risk). Time series of standardized indicators of morbidity per 100 thousand population for 2011–2021 were analyzed. with the calculation of linear trend models. The influence of the smoking prevalence on the morbidity dynamics was assessed by comparing the morbidity trends in periods characterized by an increase and decrease in smoking among men and women, taking into account the 5-year latent period of the development of MN (2011–2017, 2018–2021). Results. In 1990–2013, the prevalence of smoking steadily decreased among men and significantly increased among women. After the adoption in 2013 of Federal Anti-Tobacco Law, smoking among women, as well as among men, began to steadily decline. In 2011–2017, there was a decrease in the incidence of TBLC, LC among men and an increase among women. In 2018–2021 there was the same downward trend among men and women. The incidence of liver cancer among men and women increased during 2011–2021. Conclusion. The incidence of TBLC, LC is significantly associated with the smoking prevalence. A decrease in the smoking prevalence among the population may lead to a decrease in the incidence of tobacco-related MN.
Assessing the effects of distinct biologic therapies on rheumatoid arthritis pain by nociceptive, neuropathic and nociplastic pain components: a randomised feasibility study
Authors: Ahmed Liban , Biddle Kathryn , Blundell Anna , Koushesh Soraya , Kiely Patrick , Mein Gill , Sedgwick Philip , Sofat Nidhi 
Published: October 2023

Abstract
Background
Pain management is a major unmet need in people with rheumatoid arthritis (RA). Although many patients are treated with Disease Modifying Anti-Rheumatic Drugs (DMARDS), including biologic therapies, many people with RA continue to experience significant pain. We aimed to determine whether performing a comprehensive pain evaluation is feasible in people with active RA receiving conventional DMARDs and biologic therapies.
Methods
The BIORA-PAIN feasibility study was an open-label, randomised trial, which recruited participants suitable for treatment with biologic therapy. The primary feasibility outcomes were recruitment, randomisation and retention of eligible participants. All participants underwent pain assessment for nociceptive, neuropathic and nociplastic pain during the 12-month study period, with quarterly assessments for VAS (Visual Analogue Scale) pain, painDETECT and QST (Quantitative Sensory Testing). This trial was registered in clinicaltrials.gov NCT04255134.
Results
During the study period, 93 participants were screened of whom 25 were eligible; 13 were randomised to adalimumab and 12 to abatacept. Participant recruitment was lower than expected due to the Covid-19 pandemic. Pain assessments were practical in the clinical trial setting. An improvement was observed for VAS pain from baseline over 12 months, with a mean (SEM) of 3.7(0.82) in the abatacept group and 2.3(1.1) in the adalimumab group. There was a reduction in painDETECT and improvement in QST measures in both treatment groups during the study. Participant feedback included that some of the questionnaire-based pain assessments were lengthy and overlapped in their content. Adverse events were similar in both groups. There was one death due to Covid-19.
Conclusions
This first-ever feasibility study of a randomised controlled trial assessing distinct modalities of pain in RA met its progression criteria. This study demonstrates that it is feasible to assess participants with active RA for specific modalities of pain, including nociceptive, neuropathic and nociplastic elements. Our data suggests it is possible to stratify people for RA based on pain features. The differences in pain outcomes between abatacept and adalimumab treated groups warrants further investigation.
Trial Registration
NCT04255134, Registered on Feb 5, 2020
Role of Apache Iv and Serum Amylase Along With Urinary Amylase in Predicting Outcome of Blunt Trauma Abdomen – A Prospective Study
Authors: KATYAYAN ILA , AHMAD SHABI , SINGH SANTOSH KUMAR 
Published: October 2023

Abstract
Introduction- Blunt trauma abdomen is a leading cause of morbidity and mortality among all age groups. The pre-existing anatomical scoring systems assess the extent of injury. We worked on evaluating the use of APACHEIV which is a physiological system and hence, determines the impact of injury, in predicting the outcome of blunt trauma abdomen. We also studied the role of serial serum and urinary amylase levels in predicting specific intra-abdominal organ injured. Though the role of biochemical markers is of meagre importance in a well- equipped tertiary care centre. But in countries like India, where a majority population still depends on primary and secondary health care which are equipped with very minimal infrastructure, these markers can play a small role in triaging patients and deciding further plan of action.
Aims and objectives- To assess the role of serum and urinary amylase levels in predicting intra-abdominal organ injured. To assess the role of APACHE IV in predicting outcome of blunt trauma abdomen in terms of mortality and morbidity.
Materials and Methods- This was a prospective study carried out in the Department of Surgery of M.L.N. Medical College, Prayagraj and associated Swaroop Rani Nehru Hospital. All patients above 16 years of age with Blunt trauma abdomen were part of the study. APACHE IV score at the time of hospital admission and serum and urinary amylase on day 1, 3 and 5 was calculated.
Results- Significant correlation was seen between liver injury and urine amylase on day1 and 3; between spleen injury and urine amylase levels on day 3 and GIT injury and urine amylase on day 1 and day 5. Also, high APACHE IV score was associated with increased mortality and morbidity. Morbidity was determined particularly in terms of length of hospital stay, APACHE IV score of >44 was associated with hospital stay of more than 9 days.
A Discrete Hybrid Grey Wolf Optimizer Algorithm to solve Quadratic Assignment Problem
Authors: Panwar Karuna , Deep Kusum 
Published: October 2023

Abstract

Grey Wolf Optimizer (GWO) is one of the popular swarm intelligence-based algorithms that derived its inspiration from the hunting behaviour of wolves. GWO has been found quite an effective algorithm for solving various optimization problems. It has demonstrated impressive results, which makes it a strong candidate for finding optimal solutions to NP-hard problems. This study proposes a discrete Hybrid Grey Wolf Optimizer (HGWO) that combines GWO with Tabu Search (TS) to address the well-known combinatorial optimization problem, the Quadratic Assignment Problem (QAP). The development of efficient techniques for the QAP is an active area of research, which motivates our attempts to propose HGWO. As QAP is a combinatorial optimization problem, the continuous values obtained from the classical GWO are converted to discrete values using the largest real value mapping. In HGWO, the position of each individual is first updated by GWO and further improved by TS. The performance of HGWO is evaluated through computational experiments over 100 QAP benchmark instances. The numerical results are compared with other well-known algorithms from the literature. Also, for an unbiased and rigorous comparison, statistical tests such as Friedman non-parametric test and Wilcoxon signed rank test are conducted. The analysis of obtained numerical results demonstrated that HGWO has merit in solving QAP.
A qualitative exploration of women’s expectations of birth and knowledge of birth interventions following antenatal education
Authors: Davies Anna , Larkin Michael , Willis Lucy , Mampitiya Narendra , Lynch Mary , Toolan Miriam , Fraser Abigail , Rawling Kate , Plachcinski Rachel , Barnfield Sonia , Smith Margaret , Burden Christy , Merriel Abi 
Published: October 2023

Abstract

Background
Expectations of birth, and whether they are met, influence postnatal psychological wellbeing. Intrapartum interventions, for example induction, are increasing due to a changing pregnant population and evolving evidence, which may contribute to a mismatch between expectations and birth experience. NICE recommends antenatal education (ANE) to prepare women for labour and birth, but there is no mandated NHS ANE curriculum. We aimed to explore women’s expectations of childbirth and their understanding of common interventions and complications following NHS and non-NHS ANE.
Method
Qualitative focus groups were conducted with postnatal women (< 12 months postpartum) aged ≥ 16, who had received antenatal care at a single NHS Trust. A semi-structured topic guide was used to explore birth expectations following attendance at ANE and knowledge of birth interventions and complications. Data were transcribed and thematic analysis was undertaken by at least two researchers.
Results
46 women (mean age: 33.5years; 81% white British) participated across eight groups. Sixty-five percent were primiparous, 35% had a caesarean birth. Fifty percent attended NHS ANE and 59% non-NHS ANE. Participants perceived that a ‘hierarchy of birth’ was presented within ANE classes, where a ‘better birth’ involved vaginal birth, minimal pain relief and limited intervention. Participants described expectations of control and choice over their birth, though some described being encouraged to be open-minded about the course it may take. Participants identified a mismatch between their expectations and subsequent experiences, which adversely impacted their psychological wellbeing. While participants received information about common birth interventions and complications, limited time spent on these during classes resulted in expectations that they were rare. Participants felt that receiving sensitively presented information about the frequency of interventions could prepare women and support their psychological wellbeing after birth.
Conclusions
Women’s expectations of birth are informed by ANE which may precipitate a mismatch between expectations and experience. Better information about risk factors and frequency of labour and birth interventions may support women to develop evidence-informed expectations of birth, reducing the expectation-experience gap, with consequent impact on maternal postnatal wellbeing. A mandatory minimum curriculum for ANE is needed to ensure high-quality education is available to all.
Interpreting clinical trial outcomes marred by placebo response with an assessment of false-negative and true-negative clinical trials in depression using propensity-weighting
Authors: Gomeni Roberto , Hopkins Seth , Bressolle-Gomeni Francoise , Fava Maurizio 
Published: October 2023

Abstract
The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in major depressive disorders. The conventional study designs, randomizations, and statistical approaches do not account for the baseline distribution of major non-specific prognostic and confounding factors such as the individual propensity to show a placebo effect (PE). Therefore, the conventional analysis approaches implicitly assume that the baseline PE is the same for all subjects in the trial even if this assumption is not supported by our knowledge on the impact of PE on the estimated treatment effect (TE). The consequence of this assumption is an inflation of false negative results (type II error) in presence of a high proportion of subjects with high PE and an inflation of false positive (type I error) in presence of a high proportion of subjects with low PE value. Differently from the conventional approach, the inverse of the estimated PE probability was used as weight in the mixed-effects analysis to assess TE in the PSW analysis. The results of this analysis indicated an enhanced signal of drug response in the failed trial (ClinicalTrials.gov NCT00584974) and confirmed the absence of drug effect in the negative trial (ClinicalTrials.gov NCT0058497). This approach can be considered as a reference approach that minimize the risk of inflating either type I or type II error in contrast to what happens in the analyses of RCT studies conducted with the conventional statistical methodology.
A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case
Authors: Zhong Ruiqi , Chang Ziyi , Wang Xiuhong , Zhong Dingrong 
Published: October 2023

Abstract

Papillary ductal carcinoma in situ (DCIS) is a subtype of DCIS characterized by the neoplastic proliferation of epithelial cells with a papillary structure and confined to the mammary ductal-lobular system. Tall cell carcinoma with reversed polarity (TCCRP) is a rare subtype of invasive breast carcinoma with low malignant potential, which has recently been recognized as a separate entity in the 2019 WHO Classification of breast tumors. Here, we describe the case of a 54-year-old woman with a finding of growing nodular lesion through breast ultrasonographic screenings, whose morphological features, immunohistochemical results, and molecular genetic studies suggest overlapping features of DCIS and TCCRP. Therefore, we hypothesized that it might be a new DCIS subtype with tall cells and reversed polarity of the mammary gland.
A prediction model of preeclampsia in hyperglycemia pregnancy
Authors: Fang Yan , Liu Huali , Li Yuan , Cheng Ji , Wang Xia , Shen Bing , Chen Hongbo , Wang Qunhua 
Published: October 2023

Abstract
Background
Hyperglycemia in pregnancy (HIP) and preeclampsia (PE) are common pregnancy complications. Identifying high-risk factors for preeclampsia in pregnant women with hyperglycemia and predicting the occurrence of preeclampsia can contribute to disease grading management. This study aimed to develop a predictive model for the development of PE in pregnant women with HIP through the information of routine pregnancy care to provide a primary screening for more effective interventions.
Method
The clinical data from 951 pregnant women with hyperglycemia who delivered after 34 weeks of gestation were collected retrospectively. Observation indicators included liver and kidney function factors testing at 24–29+ 6 weeks gestation, maternal age, and basal blood pressure. The indicators were screened univariately, and the "rms" package was applied to explore the factors associated with PE in HIP pregnancy by stepwise regression. Multivariable logistic regression analysis was used to develop the prediction model. Based on the above results, a nomogram was constructed to predict the risk of PE occurrence in pregnant women with HIP. Then, evaluate the model from different perspectives. The internal validation was performed using the bootstrap procedure.
Results
Multivariate logistic regression analysis showed that cystatin C, uric acid, glutamyl aminotransferase, urea nitrogen, and basal systolic blood pressure as predictors of PE in pregnancy with HIP. The predictive model yielded an area under curve (AUC) value of 0.8031 (95% CI:0.7383–0.8679), with an optimal threshold of 0.0805, at which point the sensitivity was 0.8307 and specificity of 0.6604. Hosmer–Lemeshow test values were P = 0.3736, Brier score value was 0.0461. After 1000 Bootstrap re-samplings for internal validation, the AUC was 0.7886, the Brier score was 0.0478 and the predicted probability of the calibration curve was similar to the actual probability. A nomogram was constructed based on the above to visualize the model.
Conclusion
This study developed a model for predicting PE in pregnant women with HIP, achieving high predictive performance of PE risk through the information of routine pregnancy care.