bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical Cycling: The Obstacles to Moving Forward with Systemic Psoriasis Therapies and How to Characterize the Systemic Ready Patient
Authors: Shah Milaan , Miller Lauren , Casquejo Robert , Chao TJ , DiRugierro Douglas , Gautier Kirk , Glover Holly , Kucera Kristine , Nguyen Andrea , Pansch Leigh Ann , Volz Joleen , Young Melodie S. , Burshtein Joshua , Zakria Danny 
Published: January 2024

Background: Psoriasis is a chronic, inflammatory disease with numerous negative physical and psychosocial impacts. Topicals are a mainstay of treatment, particularly for disease with minimal skin involvement, but they are limited due to an inability to target systemic symptoms and a lack of convenience, patient adherence, and patient satisfaction. Given its systemic implications, many patients with psoriasis are undertreated including those with limited body surface area (BSA) involvement. With a growing role in providing dermatological services, physician assistants and nurse practitioners can benefit from additional guidance on how to appropriately treat these patients, as the current clinical recommendations require further expansion, and the criteria for what qualifies as adequate treatment and response are incomplete.
Methods: Two comprehensive literature searches of PubMed, Scopus, and Google Scholar were completed for English-language original research articles on the use of topical versus systemic medications for psoriasis and its comorbidities. A panel of 11 dermatology physician assistants and nurse practitioners with expertise in managing psoriatic disease gathered to review the selected literature and form consensus statements with clinical recommendations for treating psoriasis. A modified Delphi process was employed to approve each statement and a strength of recommendation was assigned to each statement using the Strength of Recommendation Taxonomy (SORT) criteria.
Results: The two literature searches produced 98 and 76 articles, respectively, that met search criteria. After screening the articles for relevance to the discussion topic, 19 articles were distributed to the panelists for review prior to the roundtable discussion. The panel unanimously voted to adopt 10 consensus statements and recommendations, 4 of which were given a strength of “A”, 1 of which was given a strength of “B”, and 5 of which were given a strength of “C”.
Conclusion: Psoriasis is a systemic disease with cutaneous manifestations and should be considered as such for adequate treatment. The 10 consensus statements created by the experts provide clinical recommendations on the systemic effects of psoriasis and important treatment considerations that can help guide clinicians on how to appropriately treat psoriasis of all severities. Furthermore, an emphasis is placed on recognizing treatment goals and making the next appropriate clinical decision for patients with mild to moderate disease who fail topical therapy.
Prevalence of Pruritus with Use of Metformin and Other Oral Hypoglycemic Agents
Authors: Sattele Lauren , Linkous Courtney , Andrews Laura , Shope Chelsea , Strat Nicholas , Wine Lee Lara 
Published: January 2024

Introduction: Metformin is being prescribed with increasing frequency for many dermatologic indications.1 This has resulted in anecdotal evidence correlating metformin use with pruritus, but the evidence is limited to case reports. 2,3 We aimed to investigate the association between metformin use and pruritus.
Methods: Using the FDA Adverse Event Reporting System (FAERS), we performed a retrospective review of patients taking metformin, canagliflozin, insulin lispro, and insulin glargine between January 1, 2012, and November 14, 2022. Data was analyzed using Chi square and Fisher’s exact testing, with Bonferroni adjusted column proportions.
Results: Prevalence of pruritus for patients taking metformin was 0.7%, canagliflozin 0.9%, insulin lispro 0.4%, and insulin glargine 0.6%. Canagliflozin was significantly more likely to cause pruritus than both insulin lispro and glargine (p-value<0.05). Reports of pruritus by metformin users was not significantly different than the other three oral hypoglycemics (p-value>0.05).
Conclusion: Our results suggest that metformin is not significantly associated with pruritus and may be used for treatment of dermatologic conditions with little concern for this adverse event. Canagliflozin, however, was significantly likely to cause pruritus. General practitioners should consider counseling canagliflozin users on this significant adverse event.
Bimekizumab Efficacy Through 3 Years in Patients with Moderate to Severe Plaque Psoriasis: Long-term Pooled Analysis from BE BRIGHT
Authors: Lebwohl Mark , Strober Bruce , Foley Peter , Langley Richard G. , Tada Yayoi , Hampton Philip , Davis Leah , Wiegratz Susanne , Hoepken Bengt , Lambert Jérémy , Kokolakis Georgios 
Published: January 2024

Introduction: A key factor of biologic discontinuation in plaque psoriasis patients is loss of response over time; long-term treatment efficacy is therefore important.1 Here, 3-year efficacy of bimekizumab (BKZ) from a pooled analysis of patients with moderate to severe plaque psoriasis across 3 phase 3 clinical trials and their open-label extension (OLE) is reported.
Procedure/study: Data were pooled from the 52-week BE VIVID and 56-week BE SURE and BE READY phase 3 trials, and their common OLE BE BRIGHT.2–5 Included patients received BKZ 320 mg every 4 weeks (Q4W) then switched to Q4W or Q8W maintenance dosing from Week 16 onwards, and entered the OLE; from OLE Week 48 or the next scheduled visit, all patients received BKZ 320 mg Q8W. Proportions of patients achieving ≥90% improvement from baseline in Psoriasis Area and Severity Index (PASI 90), PASI 100, and Dermatology Life Quality Index (DLQI) 0/1 are reported through Year 3 using modified non-responder imputation: patients who discontinued treatment due to lack of efficacy or treatment-related adverse events were considered non-responders at subsequent timepoints; multiple imputation was used for all other missing data.
Results: 771 patients received BKZ continuously in the feeder studies and entered the OLE. Among these, at Week 16, 90.9%, 65.8%, and 71.5% achieved PASI 90, PASI 100, and DLQI 0/1, respectively. At Year 1, 93.7%, 76.6%, and 83.1% of all BKZ-treated patients achieved PASI 90 (Week 52), PASI 100 (Week 52), and DLQI 0/1 (Week 48/52), respectively. Responses were durable to Year 3 (OLE Week 96): 91.0%, 70.3%, and 82.8% of all BKZ-treated patients achieved PASI 90, PASI 100, and DLQI 0/1, respectively. Similar trends were observed in the subset of patients that received BKZ Q4W/Q8W/Q8W (initial/maintenance/OLE).
Conclusion: High and durable clinical and health-related quality of life responses were observed over 3 years of BKZ treatment across 3 phase 3 trials and their OLE.
Funding: UCB Pharma.
“Who is my Neighbour? Interfaith Dialogue and Theological Formation” (Responses)
Authors: Jean Duhaime , Gilbert Sherril , Guillet Hassan 
Published: January 2024

The following are three response papers that were presented at the “Who is My Neighbour? Interfaith Dialogue and Theological Formation Conference,” held on October 19, 2022, and are indirectly responding to Amy-Jill Levine's discussion on Christian-Jewish dialogue.
The first response paper by Jean Duhaime, entitled “Christian-Jewish Dialogue and Theological Formation,” discusses how Christian-Jewish dialogue has been viewed and theologically negotiated in the Catholic tradition since Vatican II. By also addressing various Jewish reactions to the shift in Catholic attitudes towards the Jewish tradition, Duhaime illustrates the work still needed to be done for the Catholic Church to clarify its understanding of the relationship between Christianity and Judaism while simultaneously highlighting the value of including Jewish-Christian dialogue in the formation and training of religious leaders.
The second response paper by Sherril Gilbert, entitled “Why Training in the Art of Interreligious Dialogue Is Necessary for Theological Education: Thinking About ‘Who Is My Neighbour?’ From a Jewish Perspective,” discusses her personal experience in the seminary and her work as a Rabbi in multifaith contexts. Rabbi Sherril Gilbert’s response shifts the focus from the dialogue of theological exchange to what interreligious dialogue theorists would call “the dialogue of life” – which is to say, she articulates the wholistic value of interfaith dialogue, and, in doing so, demonstrates why it is crucial to incorporate a concern for interfaith dialogue into modern theological education.
The last response paper by Hassan Guillet, entitled “La Table interreligieuse de concentration du Québec: A Case Study” examines his personal experiences with interfaith dialogue during the COVID-19 pandemic, as a founding member of the Table Interreligieuse de concertation du Québec. He explains how this experience opened his eyes to the power of interfaith dialogue and collaboration, and also to the need to expand interfaith dialogue initiatives to include as many faith communities as possible, including Indigenous faith communities that are not as clearly demarcated as, say, Christianity, Judaism, or Islam
El uso de inteligencia artificial y sus desafíos para la evaluación académica: una revisión de la literatura
Authors: VanderLinde Guillermo , Mera Cury Tamara 
Published: January 2024

El procesamiento de lenguaje natural (NLP) ha sido estudiado en la industria de la computación durante mucho tiempo. Entre los constantes avances tecnológicos se ha logrado el desarrollo de complejos modelos de inteligencia artificial (IA), incluyendo Chat Generative Pre-Trained Transformer (GPT chat) cuyo uso, puesto a disposición desde noviembre de 2022, ha mostrado la tendencia de irse expandiendo. Los modelos desarrollados tienen un potencial preocupante para la evaluación académica porque pueden llevar a cabo una gama de actividades lingüísticas y generar reacciones humanas. Considerando esta problemática, el objetivo de este artículo es examinar las potenciales ventajas y desventajas del uso de ChatGPT y otras tecnologías NLP en la escritura y su evaluación, según la revisión de la literatura, para llamar la atención sobre las preocupaciones éticas planteadas por su uso. Para ello, se realizó una búsqueda en la literatura que incluía artículos en Google Académico y el resultado de la búsqueda aportó 12 artículos con un alto número de citaciones. Se utilizó metodología cualitativa para el estudio, lo que implica la lectura y el análisis de las fuentes para encontrar información pertinente, en interés de responder a los objetivos de la investigación. Las palabras clave como "GPTChat", "contenido generado por IA", "escritura académica" y "procesamiento de lenguaje natural" “fraude (ética) en las evaluaciones” guiaron la búsqueda. Los hallazgos de este análisis preliminar apuntan a que el ChatGPT y otras técnicas de NLP podrían aumentar la eficiencia de la escritura académica y la investigación. Sin embargo, su uso también plantea preocupaciones sobre cómo puede afectar la fiabilidad y la validez del trabajo académico. El estudio subraya la necesidad de explorar minuciosamente las posibles aplicaciones, peligros y limitaciones de estas tecnologías e, igualmente, enfatiza el valor de debates en profundidad y preocupaciones morales en torno a su aplicación.
Pengelolaan Program Belajar Dari Rumah (BDR) Pada Masa Covid-19 Di Sekolah Dasar Kecamatan Narmada
Authors: Kayatarno Kayatarno , Rusdiawan Rusdiawan , Hakim Mansur 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui perbedaan pengelolaan program Belajar Dari Rumah (BDR) pada masa covid 19 di Sekolah Dasar Kecamatan Narmada dari berbagai variabel (jenis kelamin, status kepegawaian, status sertifikasi, dan masa kerja). Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Populasi dalam penelitian ini adalah 200 orang guru SD yang mengisi instrumen survei di Kecamatan Narmada. Teknik pengambilan sampel adalah random sampling menggunakan rumus Isac dan Michael untuk tingkat kesalahan 5%, sehingga didapat sampel minimal sebanyak 127 responden. Pengumpulan data pengelolaan BDR menggunakan kuesioner google form yang disebar secara online melalui whatsapp. Keseluruhan data dianalisis secara kuantitatif dengan menggunakan analisis komparatif non parametrik karena data tidak berdistribusi normal. Hasil penelitian menunjukkan adanya perbedaan yang signifikan dalam pengelolaan program BDR pada masa covid-19 di SD Kecamatan Narmada berdasarkan variabel status kepegawaian. Sedangkan pengelolaan program BDR pada masa covid-19 di SD Kecamatan Narmada berdasarkan variabel jenis kelamin, status sertifikasi, dan masakerja tidak ada perbedaan yang signifikan.
Manajemen Pelaksanaan Program Dana Bantuan Operasional Sekolah
Authors: Murni Dwi , Sudirman Sudirman , Waluyo Untung , Asrin Asrin , Fahruddin Fahruddin 
Published: January 2024

Pendanaan pendidikan yang terkenal dengan program dana BOS, menuntut sekolah agar dapat membuat rencana, melaksanakan, mengevaluasi dan mempertanggungjawabkan pengendalian anggaran pendidikan secara jelas kepada pemerintah dan masyarakat. Sekolah harus membuat prioritas skala keperluan sekolah yang terpenting dan berdampak langsung kepada siswa dalam kegiatan belajar mengajar berdasarkan petunjuk teknis (juknis) yang ditetapkan pemerintah. Kepala sekolah berperan sebagai penanggung jawab pemanfaatan dana BOS di sekolah mempunyai tugas yang besar untuk mengelola distribusi pendanaan untuk operasional sekolah. Penelitian ini adalah penelitian kualitatif dengan metode deskriptif. Teknik pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Prosedur analisis data dilakukan melalui pengumpulan data, reduksi data, penyajian data dan verifikasi. Pemeriksaan keabsahan data dengan uji kredibility, transferability, defendability dan konfirmability. Hasil penelitian menemukan bahwa Proses pelaksanaan dilakukan dengan pembelanjaan sesuai perencanaan dan membuat pembukuan keuangan. Kesimpulannya adalah manajemen dana Bantuan Operasional Sekolah dilakukan dengan mengikuti Permendikbud RI Nomor 6 tahun 2021 akan tetapi dalam manajemen perencanaan, pengorganisasian, pelaksanaan dan pelaporan belum optimal karena masih menemui berbagai kendala. Rekomendasi dari penelitian ini ke depan dapat berguna bagi sekolah, peneliti dan masyarakat umum.
The double burden of COVID-19 and cancer at the Uganda Cancer Institute
Authors: Anumolu Natalie , Bojang Matida , Mulamira Pius , Jankowski Courtney , Lechleitner Kia , Abunike Sarah , Kasasa Simon , Lukande Robert , Niyonzima Nixon , Beyer Kirsten 
Published: January 2024

Background Cancer is increasingly diagnosed in Africa, with more than one million new diagnoses annually. In Uganda, the Uganda Cancer Institute (UCI) is the primary cancer care facility, with patients travelling long distances to this facility to receive care. During the COVID-19 pandemic, cancer care was disrupted on several levels, including prevention, screening, diagnosis, treatment, and follow-up. National lockdowns impeded patient access to UCI and halted cancer screening. Methods This study used qualitative interviews to obtain primary data from professionals working at UCI. Interviews were conducted from April 2022 to January 2023. KI (key informants) ’s were purposively selected, identified by colleagues at UCI and recruited through email and WhatsApp messaging. Verbal consent was obtained. Thirty to 60-minute open-ended interviews conducted virtually and in person were audio recorded and transcribed verbatim. Transcripts were coded via MAXQDA software and analyzed to identify themes. Results Thematic analysis revealed three major challenges to cancer care during COVID-19. First, UCI experienced logistical barriers such as travel restrictions, staff shortages, and insufficient protective gear. Second, staff adapted to the inflexible national lockdown policy for chronic health care with modifications to treatment regimens. Third, KI reported a significant mental health burden and reflected on how care should be improved. Conclusions As colleagues got infected, UCI staff organized their training, discussed treatment plans with colleagues, and continued to care for patients at personal risk. Resilience characterized UCI’s response to COVID-19. They adapted treatment protocols to their setting, many of which remain the standard of care today. At the same time, there is a need for capacity building tailored to the Ugandan context to provide cancer care effectively in case of another pandemic.
Pengaruh Penggunaan Alat Permainan Edukatif Dalam Hasil Belajar Pendidikan Anak Usia Dini Di RA Al – Uswah Delanggu
Authors: Najmi Raudhatun 
Published: January 2024

Pendidikan anak usia dini adalah salah satu lembaga pendidikan yang memegang peran penting untuk membantu pemerintah mempersiapkan generasi muda sedini mungkin, yang sesuai dengan tujuan pendidikan anak usia dini yaitu membantu meletakkan dasar kearah perkembangan sikap perilaku, pengetahuan, keterampilan dan daya cipta yang diperlukan oleh anak didik. Pembelajaran merupakan suatu kegiatan melaksanakan kurikulum suatu lembaga pendidikan agar dapat mempengaruhi para siswa mencapai tujuan pendidikan yang telah ditetapkan. Dalam mencapai tujuan tersebut siswa berinteraksi dengan lingkungan belajar yang diatur guru melalui proses pembelajaran. Lingkungan belajar yang diatur oleh guru mencakup tujuan pembelajaran, bahan pembelajaran, metodologi pembelajaran, dan penilaian pembelajaran.
Penelitian ini pada hakekatnya bertujuan untuk memberikan gambaran yang lebih mendalam tentang analisis identifikasi pemanfaatan alat permainan edukatif (APE) dalam meningkatkan hasil belajar pada anak usia dini. Dimana hasil penelitian ini pada akhirnya diperoleh data yang menggambarkan analisis identifikasi pemanfaatan alat permainan edukatif (APE) dalam meningkatkan hasil belajar pada anak usia dini.
PENGARUH MEDIA BONEKA UNTUK PEMBELAJARAN SEKS ANAK KELOMPOK B DI TK ABA 11 GIRI
Authors: Savitri Ervina Nanda , Fatmawati Fitri Ayu 
Published: January 2024

Penelitian ini dilaksanakan di TK ABA 11 Giri yang terdapat kurangnya frekuensi pembelajaran seks dan media yang kurang variatif dalam pembelajaran seks anak kelompok sehingga membuat pembelajaran seks tidak maksimal. Hal ini terlihat dari 49 peserta didik terdapat 27 peserta didik yang kurang memahami materi pembelajaran seks. Tujuan dari penelitian ini mengetahui adanya pengaruh media boneka untuk pembelajaran seks anak kelompok B di TK ABA 11 Giri. Penelitian ini menggunakan pendekatan kuantitatif eksperimen dengan desain nonequivalent control group design dan menggunakan sampel non probability sampling.
Data yang telah didapat menunjukan nilai rata-rata pretest dan posttest kelompok kontrol 128 meningkat menjadi 189 dan kelompok eksperimen 134 meningkat menjadi 194. Nilai hasil test statistic T hitung > T tabel dengan sig 0.05 pada kelompok kontrol 3.201 > 2.160 dan kelompok eksperimen 3.203 > 2.145 maka Ha diterima Ho ditolak yang artinya adanya pengaruh pada kelompok kontrol dan eksperimen dalam pembelajaran seks..
Analisis kesalahan konsep Siswa pada materi sistem pertidaksamaan linear dua variabel
Authors: Nurhayati Yanti , Ratnaningsih Nani 
Published: January 2024

Penelitian ini bertujuan untuk mendeskripsikan miskonsepsi dalam menyelesaikan soal sitem pertidaksamaan linear kuadrat ditinjau dari pengamatan Guru dan yang Guru temukan. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitan berjumlah 34 orang Siswa kelas X MIPA di salah satu SMA Negeri yang ada di Tasikmalaya. Metode penelitian yang digunakan adalah dengan memberikan soal sistem pertidaksmaan linear dua variabel yang didalamnya menyangkut linear-kuadrat dan kuadrat-kuadrat. Hasil penelitian menunjukkan bahwa miskonsepsi pada penyelesaian soal sistem pertidaksamaan linear dua variabel pada indikator pertama terdapat 45% Siswa belum dapat menerapkan rumus, 61% belum dapat memenuhi indikator kedua, dalam indikator kedua ini dibagi menjadi empat bagian yaitu 41% Siswa tidak menggambarkan model pertidaksamaan linear dua variabel kedalam diagram kartesius, 4% Siswa dapat menggambar model pertidaksamaan dengan lengkap, 9% Siswa dapat menggambar model kedalam diagram kartesius dengan tanpa kesalahan dan sisanya 7% sudah menggambarkan kedalam diagram karetsius namun masih ada yang belum tepat, pada indikator ketiga 11% Siswa melakukan kesalahan dalam penggunaan metode yaitu miskonsepsi dalam penentuan daerah hasil pertidaksamaan tersebut.
On Averroes’ response to al-Ghazali’s critique of Falsafa interpretation of bodily resurrection
Authors: Ibrahim T. , Efremova N. V. 
Published: January 2024

This article serves as an introduction to the translation of the section on bodily resurrection, from the book «The Incoherence of the Incoherence» (Tahāfut at-Tahāfut) of the peripatetic philosopher Ibn Rushd (Averroes, 1126–1198), written in response to the work of the theologian-asharite al-Ghazali (1058–1111) «The Incoherence of the Philosophers» (Tahāfut al-Falāsifa). The paper reveals the presentist-intellectualist intention of Falsafa eschatology; it also gives a compendium of the polemics of two thinkers around two related issues that are the rational proofs for the immateriality of the soul and its incorruptibility. Moreover, the research provides a brief summary of the section of the Ghazalian book regarding resurrection. The authors also disclose the connection between the book of Ibn Rushd and his earlier theological and polemical treatises «On the correlation between philosophy and religion» and «On the methods of proof for the principles of creed».The article is intended to serve as an introduction to the translation of the section on bodily resurrection, which concludes the book of the peripatetic philosopher Ibn Rushd (Averroes, 1126–1198) «The Inconsistency of Inconsistency», compiled in refutation of the critical treatise «The Inconsistency of the Teachings of the Philosophers» by the mutaqallimah-ash'arite al-Ghazali (1058–1111).
Ibn-Rushd (Averroes). The Incoherence of the Incoherence. Part Six
Authors: Ibrahim T. , Efremova N. V. 
Published: January 2024

This work completes the series of publications that began in № 3 (2020), which is a translation of selected sections from the book «The Incoherence of the Incoherence» (Tahāfut at-Tahāfut), written by a peripatetic philosopher Ibn Rushd (Averroes, d. 1198) in response to the polemical treatise of asharite mutakallim al-Ghazali (d. 1111) «The Incoherence of the Philosophers» (Tahāfut al-Falāsifa).Dealing in this section with the third of the “heretical” (kufr) theses attributed to philosophers – about the alleged denial of bodily resurrection and sensory retribution, Ibn Rushd rejects this accusation and points out that from a Falsafa point of view, such principles of religion are necessary for the establishment of practical and theoretical virtues, and therefore are not subject to discussion. The philosopher notes the advantage of a bodily description of afterlife, however claims that bodies will be similar to earthly ones, but not identical to them.