bluuebunny/crossref_metadata_2025_split huggingface dataset:
More Similar than Different: Memory, Executive Functions, Cortical Thickness, and Glucose Metabolism in Biomarker-Positive Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia
Authors: Keith Cierra M. , Haut Marc W. , D’Haese Pierre-François , Mehta Rashi I. , Vieira Ligo Teixeira Camila , Coleman Michelle M. , Miller Mark , Ward Melanie , Navia R. Osvaldo , Marano Gary , Wang Xiaofei , McCuddy William T. , Lindberg Katharine , Wilhelmsen Kirk C. 
Published: January 2024

Background: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are typically associated with very different clinical and neuroanatomical presentations; however, there is increasing recognition of similarities. Objective: To examine memory and executive functions, as well as cortical thickness, and glucose metabolism in AD and bvFTD signature brain regions. Methods: We compared differences in a group of biomarker-defined participants with Alzheimer’s disease and a group of clinically diagnosed participants with bvFTD. These groups were also contrasted with healthy controls (HC). Results: As expected, memory functions were generally more impaired in AD, followed by bvFTD, and both clinical groups performed more poorly than the HC group. Executive function measures were similar in AD compared to bvFTD for motor sequencing and go/no-go, but bvFTD had more difficulty with a set shifting task. Participants with AD showed thinner cortex and lower glucose metabolism in the angular gyrus compared to bvFTD. Participants with bvFTD had thinner cortex in the insula and temporal pole relative to AD and healthy controls, but otherwise the two clinical groups were similar for other frontal and temporal signature regions. Conclusions: Overall, the results of this study highlight more similarities than differences between AD and bvFTD in terms of cognitive functions, cortical thickness, and glucose metabolism. Further research is needed to better understand the mechanisms mediating this overlap and how these relationships evolve longitudinally.
Usability, Appeal, and Relevance of Music and Wellbeing Training for Carers of People with Dementia: A Think-Aloud Study
Authors: Garrido Sandra , Markwell Holly 
Published: January 2024

Background: Personalized music listening can be highly effective in supporting people experiencing changes in mood and behavior due to Alzheimer’s disease and other conditions causing dementia. However, a lack of staff education can be a barrier to effective use of music in residential aged care. Objective: This study investigates the usability, appeal and relevance of an online training course designed to help care staff develop personalized music programs for people living with dementia in their care. Methods: A mixed methods approach was taken in which 13 participants took part in a think-aloud session while using the training. Qualitative data from the think-aloud session and interviews were triangulated with results of a survey evaluation of the training. Results: Themes relating to Engagement, Usability and Appeal, Pedagogical Design and Content, and Transfer, Impact and Barriers to Uptake were discussed. Results indicated that participants regarded the virtual environment and pedagogical design as of high quality, although some minor issues in navigability were identified. Participants also found the training to be highly relevant to their roles as caregivers and reported ways they would incorporate key concepts into care practices. However, ongoing barriers to implementation of such training were identified including systemic issues that contribute to a culture of focus on physical care. Conclusions: Consistency of navigation and clear instructions for interacting with content are important in training of time-poor care staff. Linking training to industry standards can provide important motivation for implementation of training, although systemic barriers can impede real-world change.
Real-World Outcomes in Patients with Spinal Muscular Atrophy Treated with Onasemnogene Abeparvovec Monotherapy: Findings from the RESTORE Registry
Authors: Servais Laurent , Day John W. , De Vivo Darryl C. , Kirschner Janbernd , Mercuri Eugenio , Muntoni Francesco , Proud Crystal M. , Shieh Perry B. , Tizzano Eduardo F. , Quijano-Roy Susana , Desguerre Isabelle , Saito Kayoko , Faulkner Eric , Benguerba Kamal M. , Raju Dheeraj , LaMarca Nicole , Sun Rui , Anderson Frederick A. , Finkel Richard S. 
Published: January 2024

Background: Long-term, real-world effectiveness and safety data of disease-modifying treatments for spinal muscular atrophy (SMA) are important for assessing outcomes and providing information for a larger number and broader range of SMA patients than included in clinical trials. Objective: We sought to describe patients with SMA treated with onasemnogene abeparvovec monotherapy in the real-world setting. Methods: RESTORE is a prospective, multicenter, multinational, observational registry that captures data from a variety of sources. Results: Recruitment started in September 2018. As of May 23, 2022, data were available for 168 patients treated with onasemnogene abeparvovec monotherapy. Median (IQR) age at initial SMA diagnosis was 1 (0–6) month and at onasemnogene abeparvovec infusion was 3 (1–10) months. Eighty patients (47.6%) had two and 70 (41.7%) had three copies of SMN2, and 98 (58.3%) were identified by newborn screening. Infants identified by newborn screening had a lower age at final assessment (mean age 11.5 months) and greater mean final (SD) CHOP INTEND score (57.0 [ 10.0 ] points) compared with clinically diagnosed patients (23.1 months; 52.1 [ 8.0 ] points). All patients maintained/achieved motor milestones. 48.5% ( n = 81/167) experienced at least one treatment-emergent adverse event (AE), and 31/167 patients (18.6%) experienced at least one serious AE, of which 8/31 were considered treatment-related. Conclusion: These real-world outcomes support findings from the interventional trial program and demonstrate effectiveness of onasemnogene abeparvovec over a large patient population, which was consistent with initial clinical data and published 5-year follow-up data. Observed AEs were consistent with the established safety profile of onasemnogene abeparvovec.
Billboard-style posters preferred overall at two conferences, but should include more methods and limitations
Authors: Oronje Benard , Morrison Mike , Suharlim Chris , Folkman Kimberly , Glaude-Hosh Angela , Jeisy-Scott Victoria 
Published: January 2024

Scientific posters are a frequently used medium of communication at conferences and have grown in popularity over the last decades. However, the design of the traditional poster has largely remained stagnant despite emergence of new relevant research that could have unique implications for how scientific posters are designed for optimal learning. In this study, we examine the impact of a new minimalist, 'billboard-style' poster designed to transmit at least one piece of knowledge more efficiently. Attitudinal reactions to new and traditional poster designs were compared in two field studies. We found the billboard-style poster was perceived as easier to learn from, more interactive, and better for promoting scientific discovery. This supports the billboard-style poster design for use in scientific poster sessions. Results also suggested that future improvements to billboard-style designs should aim to efficiently communicate study methods in addition to key findings. Ultimately, these two field studies provide some initial evidence that meaningful improvements in poster effectiveness are possible, and that billboard-style layouts may be a step in the right direction that is worth developing further.
Respon Peserta Didik terhadap Media Audio Visual Berbasis Discovery Learning pada Materi Sistem Organ dan Organisme
Authors: Rizal Khairul , Faradilla Meriza 
Published: January 2024

Pembelajaran yang menarik merupakan pembelajaran yang mampu mendorong peserta didik belajar aktif dan mandiri. Hal ini dapat diwujudkan dengan menggunakan pendekatan pembelajaran yang berkembang saat ini, salah satunya adalah dengan memanfaatkan media audio visual berbasis discovery learning sebagai strategi untuk membuat pembelajaran lebih menarik. Penelitian ini bertujuan untuk mendeskripsikan tanggapan peserta didik terhadap media pembelajaran yang cocok untuk berbagai proses pembelajaran yang pernah dilaksanakan pada mata pelajaran IPA materi sistem organ. Penelitian dilakukan secara kualitatif dengan menggunakan metode survei. Pertanyaan yang diberikan pada kuisioner ini berkaitan dengan pendapat peserta didik tentang media audio visual yang berbasis discovery learning. Penelitian dilakukan di MTsN Tungkop Kecamatan Darussalam, Kabupaten Aceh Besar. Adapun populasi penelitian ini adalah seluruh peserta didik yang berjumlah 273 peserta didik di kelas VII. Pengambilan sampel dilakukan dengan teknik sampling purposive, yaitu teknik penentuan sampel dengan pertimbangan tertentu sebanyak dua kelas dengan jumlah peserta didik 78 orang. Hasil pembagaian kuisioner telah dianalisis menunjukkan bahwa dengan media audio visual yang digunakan pada materi organ dan organisme mendapatkan respon positif dari peserta didik rata-rata sebesar 97,90%. Sehingga dapat dikatakan bahwa penggunaan media audio visual berbasis discovery learning mempengaruhi minat dan motivasi peserta didik.
Retrospective Analysis of Polyethylene Oxide and Polypropylene Oxide Block Copolymers Production and Industrial Applications (Review)
Authors: Bakhrushina E. O. , Pyzhov V. S. , Sakharova P. S. , Demina N. B. , Krasnyuk I. I. 
Published: January 2024

Introduction. Nowadays block copolymers of PEO and PPO (poloxamers, pluronics, proxanols) are among the most popular polymers in the pharmaceutical and biotechnological industries. They can be applied as effective nonionic surfactants, biological membrane stabilizers, elements of targeted delivery systems, solubilizers, as well as excipients in the technology of traditional dosage forms – gelling agents, lubricants, etc. For the past fifty years, the world's largest manufacturer of poloxamers has been the German chemical concern BASF. However, today in the Russian Federation there is a risk of defects, which defines the relevance of import substitution of this excipient.Text. The purpose of this review is to highlight the experience of production and implementation of PEO and PPO block copolymers into novel Russian scientists’ developments, comparing them with the experience of foreign research groups, which is necessary to assess the potential for import substitution. PEO and PPO block copolymers have been known in the Soviet Union since the late 60s as far as they are mentioned in textbooks of 1964 and 1973. Domestic block copolymers of PEO and PPO have been used in the oil refining industry, as well as in some branches of light industry and in the decontamination of radioactive waste. The unique domestic synthesis of PEO and PPO block copolymers was established in 1978 on the basis of the "Orgsintez" factory. Soviet poloxamers were produced under the brand name "proxanol" in a wide range of ratios of EO and PO units and molecular weights. It should be noted that today in the Russian Federation, industrial batches of the solubilizer Emuxol 268, which is close in its properties to the well-known poloxamer 188, are still produced, and block copolymers with other ratios of EO and PO units are synthesized to order.Conclusion. According to the retrospective analysis, the modern Russian industry has enough experience and resources to establish the synthesis of PEO and PPO block copolymers necessary to produce drugs and to develop innovative delivery systems and drugs. Based on the materials of the systematic review, the most complete register of known brands of PEO and PPO block copolymers synthesized over the past 50 years in our country and in the world was compiled for the first time, with a detailed description of their physicochemical properties.
The Role of Doxorubicin in the Formation of Cardiotoxicity – Generally Accepted Statement. Part I. Prevalence and Mechanisms of Formation (Review)
Authors: Andreev D. A. , Balakin E. I. , Samoilov A. S. , Pustovoit V. I. 
Published: January 2024

Introduction. Long-term use of anthracyclines during cancer chemotherapy has been associated with the development of potentially life-threatening cardiotoxicity. Despite researches ongoing since the middle of the last century, approaches to the choice of therapy remain limited.Text. Doxorubicin currently is the most widely used chemotherapy. The leading side effect mechanism of the drug is the formation of reactive oxygen species in mitochondria with the mediated development of oxidative stress, which contributes to myocardial damage. However, despite the huge number of scientific papers devoted to various aspects of doxorubicin cardiotoxicity, its prevention and treatment, this issue requires detailed investigation in order to develop more advanced methods for early diagnosis and timely cardioprotective therapy.Conclusion. The current review discusses the pathogenetic mechanisms of cardiotoxicity associated with the use of doxorubicin chemotherapy. The pathogenesis of the cardiomyocytes death mechanism will provide an opportunity to develop new diagnostic and therapeutic approaches in the clinical practice.
Методичний підхід до оцінювання властивостей бойових та транспортно-бойових вертольотів, що визначають їх спроможності по виконанню типових завдань за призначенням
Authors: Леонтьєв Олексій , Дмитрієв Андрій 
Published: January 2024

Мета роботи: удосконалення процесу оцінювання властивостей бойових та транспортно-бойових вертольотів, що визначають їх спроможності по виконанню типових завдань за призначенням.
Метод дослідження: аналіз та синтез.
Результати дослідження: запропоновано удосконалений методичний підхід до кількісного оцінювання властивостей вертольоту, що визначають його спроможності.
Теоретична цінність дослідження: результати проведеного дослідження доповнюють існуючі теоретичні дослідження та дозволили відпрацювати основні напрямки подальшого розвитку в даній сфері.
Практична цінність дослідження: результати дослідження можуть бути використані для визначення раціонального тактико-техніко-економічного обрису майбутнього вертолітного парку для потреб армійської авіації.
Цінність дослідження: в даному дослідженні здійснено аналіз існуючих методичних підходів щодо оцінювання властивостей зразків озброєння та військової техніки та запропоновано подальший розвиток відповідного науково-методичного апарату з урахуванням впливу впровадження новітніх технологій в конструкцію перспективних зразків авіаційної техніки.
Майбутні дослідження: визначені подальші кроки для проведення досліджень за напрямком підвищення ефективності управлінських рішень щодо вибору шляхів розвитку вертолітного парку армійської авіації на середньострокову та довгострокову перспективи.
Physical development and bone mineral density of children with inflammatory bowel diseases
Authors: Bavykina I. A. , Ledneva V. S. , Bavykin D. V. , Titova L. A. 
Published: January 2024

Relevance. Inflammatory bowel diseases can cause a lag in physical development and a decrease in the nutritional status of children. Therapy with glucocorticosteroids can aggravate the process of formation of the body and reduce the mineralization of bone tissue.Materials and methods. The study included 24 children aged 5 to 17 years with inflammatory bowel diseases, of which 19 patients did not use glucocorticosteroids in therapy – group 1, and group 2–5 children on hormone therapy. The groups did not differ statistically significantly in age and gender composition. In order to assess the level of physical development, an assessment of anthropometric indicators was carried out using the ANTHRO Plus program. Bone mineral density was assessed by densitometry. Statistical processing was carried out using Statistica 6.0 statistical programs and descriptive statistics methods. To compare independent groups of small volume, the method was used Mann-WhitneyResults. The evaluation of length, body weight and body mass index was carried out, as a result, it was found that the majority of patients who participated in the study had an average level of physical development in the population, no statistically significant differences were found by any criterion (p > 0.05). When assessing the BMD in children with IBD who did not use hormone therapy in the treatment of diseases, it was found that the Z-Score level within the reference values was observed in 57.9% (n = 11) children, 1 (5.3%) child has below –2.49 and in 36.8% (n = 7) the Z-Score level was determined in the range from –1.00 SD to –2.49 SD. More than half of the patients in group 2 had no changes in BMD (60%; n = 3), the Z-Score value in 1 (20%) patient corresponded to the level of osteopenia and in 1 (20%) child – osteoporosis. No differences were found between the groups and depending on physical development, gender or age (p > 0.05).Conclusions. It was found that children, regardless of the use of hormone therapy they have similar indicators in the levels of physical development and bone mineralization. The importance of monitoring the studied indicators for the timely prevention of changes is noted.
Problems of quality of dermatological care for acne in adolescents
Authors: Golikova L. O. , Antonenkov Yu. E. 
Published: January 2024

Relevance. The quality of dermatological care in the treatment of acne in adolescents is under-researched. Therefore, it is relevant to analyze the problems that negatively affect the quality of care for adolescents suffering from acne.Target. To identify problems in the quality of dermatological care in relation to the treatment of acne in adolescents.Materials and methods. 20 literature sources over the past 6 years have been found. Standard methods of literature analysis (induction, synthesis and comparison of the presented information) were used.Results. The following have not been sufficiently studied: the psychological aspect of the influence of acne and its treatment on the condition of a teenager; anti-relapse effect of retinoids depending on their dose and course duration; mechanisms of acne formation in adolescents. Information about the possibility of chronic disease and/or relapse of acne in adolescents is fragmentary. Maintenance therapy in adolescents to minimize the side effects of acne treatment has practically not been developed. Problems with compliance of adolescents undergoing treatment for acne are fragmentarily studied.Conclusions. Problems in the development of individualized acne treatment algorithms for adolescents have been identified. At the same time, adolescents are at risk of developing acne and require a special approach in the treatment of acne due to their unstable psyche and the importance of young citizens as a valuable asset of the state.
Modularly engineering Rhodotorula toruloides for α-terpineol production
Authors: Lyu Liting , Chen Qiongqiong , Xue Haizhao , Mustafa Sumayya , Manzoor Shah Aabid , Huang Qitian , Zhang Yue , Wang Shuang , Zhao Zongbao Kent 
Published: January 2024

α-Terpineol is a monoterpenoid alcohol that has been widely used in the flavor, fragrance, and pharmaceutical industries because of its sensory and biological properties. However, few studies have focused on the microbial production of α-terpineol. The oleaginous yeast Rhodotorula toruloides is endowed with a natural mevalonate pathway and is a promising host in synthetic biology and biorefinery. The primary objective of this work was to engineer R. toruloides for the direct biosynthesis of α-terpineol. The improvement in monoterpenoid production was achieved through the implementation of modular engineering strategies, which included the enhancement of precursor supply, blocking of downstream pathways, and disruption of competing pathways. The results of these three methods showed varying degrees of favorable outcomes in enhancing α-terpineol production. The engineered strain 5L6HE5, with competitive pathway disruption and increased substrate supply, reached the highest product titer of 1.5 mg/L, indicating that reducing lipid accumulation is an efficient method in R. toruloides engineering for terpenoid synthesis. This study reveals the potential of R. toruloides as a host platform for the synthesis of α-terpineol as well as other monoterpenoid compounds.
Carbon intensity of mass timber materials: impacts of sourcing and transportation
Authors: Atnoorkar Swaroop , Ghatpande Omkar A. , Haile Selam L. , Goetsch Heather E. , Harris Chioke B. 
Published: January 2024

Mass timber construction is widely considered a promising alternative construction method to reduce buildings’ total life-cycle carbon emissions because wood is a carbon sink. Cross-laminated timber (CLT) panels, manufactured by gluing lumber layers with grains at right angles, are potential low-carbon alternatives to carbon-intensive concrete and steel construction. However, most environmental impact assessment studies do not consider variation in transportation impacts within the CLT supply chain when calculating life-cycle impacts. This study investigates the embodied primary energy and the global warming potential (GWP) of CLT supply chain decisions regarding the type of timber species used, the U.S. region it is sourced from, and the location of the CLT mill. Longer transport distances in the supply chain for timber and CLT panels can contribute as much as 923 MJ/m2 (20%) of the embodied primary energy of a CLT building, and the use of a higher-density timber species increases this contribution to 1246 MJ/m2 (24%), with most of that energy derived from fossil energy sources. For perspective, the GWP of a building whose CLT panels and timber have been transported by truck over 6,000 km (252–270 kgCO2/m2) is greater than the GWP of an equivalent reinforced concrete (RC) building (245 kgCO2/m2). Thus, factors like the location of CLT processing facilities and the type of timber species can significantly impact the overall life-cycle assessment and, if chosen appropriately, can mitigate the environmental impacts of CLT construction.
Neogene and Pleistocene geodynamics: the paleoseismic evolution of Armorica (Western France)
Authors: Van Vliet-Lanoë Brigitte , Authemayou Christine , Le Roy Pascal , Renouf John C. , Combes Philippe , Ego Frederic 
Published: January 2024

The evolution of the passive Armorican margin (Western France) during the Neogene and Quaternary was analyzed using field data. The morphology of the margin attests to a late Hercynian shaping, further deformation during the Mesozoic mid-Atlantic opening, during the Alpine Orogeny, and ultimately, a Late Cenozoic uplift, mostly related to an onshore isostatic accommodation in response to erosion and limited tectonic activity. A very limited strike–slip dynamic, with very low seismicity, accommodated the Neogene–Pleistocene N170 strains around the rigid Armorican terrane. The South Armorican domain and English Channel floor include shear zones that adjusted the Alpine convergence, facilitating its transpressive slip to the west. The Permo-Triassic N150 faults were reactivated during the inversion phases that began after the Bartonian under the distal control of the Alpine convergence and the decrease in the Atlantic spreading rate after 34 Ma. The Armorican marine platforms were stable after the late Eocene and slightly subsident, experiencing pulsed episodes of transient lithospheric doming during the Neogene and Quaternary. Co-seismic activity onshore without surface rupture was recorded around ∼5.3 Ma, ∼3.7 Ma, ∼2.4–1.2 Ma, and ∼400–250 ka, in tandem with an inland exhumation driven by isostatic adjustment due to an intensification of periglacial erosion at the onset of the early interstadials or by agriculture. Low-magnitude and ubiquitous shallow seismic activities seem to be related today to an isostatic uplifted old brittle–ductile transition due to the accumulation of shearing strain.