bluuebunny/crossref_metadata_2025_split huggingface dataset:
A large pulmonary nodule in a rheumatoid arthritis patient treated with tofacitinib
Authors: Her Minyoung , Park Jeongha , Lee Seung‐Geun 
Published: December 2023

AbstractPulmonary rheumatoid nodules are rare extra‐articular manifestations of rheumatoid arthritis (RA). They are usually asymptomatic but may form cavities and cause clinical symptoms. These nodules are difficult to differentiate clinically and radiologically from tuberculosis, fungal infection, or lung malignancies. Histopathological studies help in the differential diagnosis of pulmonary nodules in patients with RA; however, an effective treatment for rheumatoid lung nodules has not yet been established. This study reports a case of active RA with interstitial lung disease and a large inflammatory lung nodule that was improved with tofacitinib treatment.
How does climate risk affect corporate innovation? Evidence from China
Authors: Li Bin , Yao Yao , Usman Muhammad , Han Miaodi 
Published: December 2023

AbstractThis paper investigates the effects of climate risk on corporate innovation in China. Employing a city‐level climate risk indicator that we constructed and a sample of 21,430 firm‐year observations of Chinese‐listed companies, we find that climate risk is negatively associated with corporate innovation investment and outcome. These results are robust to alternative empirical designs and identifications. Our mechanism analyses reveal that climate risk impedes corporate innovation by motivating firms to increase cash holdings as financial reserves. Additional analyses suggest that the adverse impact of climate risk on corporate innovation is more pronounced for high‐tech firms, and less salient for firms with higher financial constraints and female Chairperson or CEO. Furthermore, the decrease in corporate innovation due to climate risk can lead to a reduction in firm value. These findings contribute to the existing literature on climate risk and corporate innovation and inform regulators and listed firms concerning climate risk.
High prevalence of depression in parents of children with Type 1 diabetes in a meta‐analysis of data from five continents
Authors: Ryan Hayley , Burgess Aaron , Jackson Clare , Hewson‐Ravenscroft Alyssa , Meiser‐Stedman Richard 
Published: December 2023

AbstractAimThis meta‐analysis identified the prevalence of depression in parents of children with Type 1 diabetes.MethodsMEDLINE, PsycINFO and CINAHL databases were searched for papers published in English from 1980 to May 2022, yielding 18 studies (N = 2044 participants). The prevalence of parental depression was pooled across the studies.ResultsThe prevalence of depression among parents of children with Type 1 diabetes was high. Random‐effects meta‐analyses estimated the prevalence of moderate depression and above in the total sample as 18.4% (95% CI 12.8–24.6; k = 17, N = 2044), with rates of 17.3% in mothers (95% CI 12.7–22.5; k = 12, N = 1106) and 9% in fathers (95% CI 4.3–15.1; k = 6, N = 199). The estimated prevalence of mild depression and above in the total sample was 32.7% (95% CI 20.3–46.6; k = 8, N = 797), with rates of 29.4% in mothers (95% CI 17.8–42.6; k = 4 N = 330) and 13.6% in fathers (95% CI 5.2–25.2; k = 2 N = 44). All results were characterised by high levels of heterogeneity. The risk of publication bias was low.ConclusionMore than 1 in 6 parents of children with Type 1 diabetes had depression in the moderate plus category. The limitations and implications of these results are discussed.
Infliximab therapy decreases the expression of serum and faecal miR‐126 and miR‐20a in paediatric Crohn's disease: A pilot study
Authors: Casertano Marianna , Trotta Maria Consiglia , Cenni Sabrina , Creoli Mara , Miele Erasmo , Martinelli Massimo , Lepre Caterina Claudia , Russo Marina , Alfano Roberto , D'Amico Michele , Strisciuglio Caterina 
Published: December 2023

AbstractAimWe aimed to evaluate the serum and faecal expression of miR‐126 and miR‐20a in children with Crohn's disease (CD) during infliximab (IFX) therapy.MethodsIn this prospective observational study, serum and faeces from CD patients were collected before IFX therapy (T0), after induction (T1) and after 6 months from IFX (T2). IFX levels were determined by Enzyme‐linked immunosorbent assay at T1 and T2. miRNAs were profiled through Real‐Time RT‐PCR. The activity of disease was evaluated through the Paediatric Crohn's disease activity index (PCDAI), serum C‐reactive protein (CRP) and faecal calprotectin.ResultsNine CD children were enrolled. Serum and faecal miR‐126 and miR‐20a levels were higher at T0 and showed a time‐dependent decrease, being significantly down‐regulated after IFX treatment at T2. Specifically, IFX levels recorded at T1 and T2 negatively correlated with the serum and faecal expression of miR‐126 and miR‐20a. Serum and faecal changes of miR‐126 and miR20‐a were positively associated with the decrease of the inflammatory marker CRP and PDCAI at all time points.ConclusionIn children with CD, IFX therapy decreases the expression of serum and faecal miR‐126 and miR‐20a, suggesting an involvement of these two miRNAs in the action of the drug.
Carbon dioxide fluxes and soil carbon storage in relation to long‐term grazing and no grazing in Icelandic semi‐natural grasslands
Authors: Thorhallsdottir Anna Gudrun , Gudmundsson Jon 
Published: December 2023

AbstractQuestionWhat is the effect of long‐term grazing and no grazing (NG) on carbon dioxide flux and soil carbon storage in Icelandic semi‐natural grasslands.LocationThree farms, with known history of land use, in W Iceland.MethodsOn each farm, we located an intensively and an extensively grazed site, which both had been constantly grazed for centuries, and a parallel site with no grazing for over 50 years. We measured net ecosystem exchange (NEE), ecosystem respiration and normalized difference vegetation index on a regular basis over the growing season. Samples were taken from 60 cm deep soil profiles for analysis of soil organic carbon (SOC).ResultsThe grazed sites showed significantly more negative NEE than the NG sites, indicating more carbon dioxide uptake on the grazed sites compared to the NG sites. The normalized difference vegetation index was also significantly higher on the grazed sites. On all farms, the total SOC content was higher in the grazed sites than in the parallel NG sites.ConclusionsThe study indicates that cessation of grazing decreases productivity and carbon dioxide uptake in a semi‐natural grassland in Iceland, as well as SOC content in the soil. Historically, all the NG sites in the study had the same grazing history as the continuously grazed sites until grazing exclusion. The measured lower SOC on the NG sites seems to indicate that, without grazing, SOC is lost with time and/or grazing is needed to maintain SOC in these grasslands.
Going green? On the drivers of individuals' green bank adoption
Authors: Merli Maxime , Pallud Jessie , Pulikova Mariya 
Published: December 2023

AbstractIn a context where individuals are increasingly more sensitive to corporate social responsibility (CSR) practices and where mobilization of savings for the energy transition is essential, our article is the first to study the drivers of online green bank adoption. By analyzing 1075 questionnaires from a panel of French individuals in charge of financial decisions in their households, we show that altruism and green consumption values are significant drivers of individuals' green banking adoption and reveal that willingness to adopt a green bank is mediated by the preference for green savings. These results extend the nascent literature dealing with the link between responsible consumption and saving behaviors. Briefly speaking, green banks (and associated savings products) have the potential to enable households to express their consumption values through their investments. That said, our results suggest that households' financial well‐being and financial literacy can be barriers to the mobilization of green savings. Our results also demonstrate the significant influence of information system variables, such as personal innovativeness and trust, on willingness to adopt green banking. By shedding light on the drivers of individuals' green bank adoption, our results provide valuable insights for the banking industry.
Identifying and shifting educators' failure pedagogical mindsets through reflective practices
Authors: Simpson Amber , Anderson Alice , Goeke Megan , Caruana Dara , Maltese Adam V. 
Published: December 2023

AbstractBackgroundIn this paper, we add to the scant literature base on learning from failures with a particular focus on understanding educators' shifting mindset in making‐centred learning environments.AimsThe aim of Study 1 was to explore educators' beliefs about failure for learning and instructional practices within their local making‐centred learning environments. The aim of Study 2 was to examine how participation in a video‐based professional development cycle regarding failure moments in making‐centred learning environments might have shifted museum educators' failure pedagogical mindsets.SampleIn Study 1, the sample included 15 educators at either a middle school or museum. In Study 2, the sample included 39 educators across six museums.MethodsIn Study 1, educators engaged in a semi‐structured interview that lasted between 45 and 75 min. In Study 2, the six museums video recorded professional development sessions.ResultsResults from Study 1 highlighted educators' failure pedagogical mindsets as either underdeveloped or rigid and absent of relational thinking between self‐ and youth‐failures. One key result from Study 2 was a shift from an abstract sense of failure as youth‐focused to a practical sense of failure as educator‐focused and/or relational (i.e., youth educator‐focused failure moments).ConclusionsBased on the results from Study 1 and Study 2, our research suggests that exploring an educator's relationship with failure is important and witnessing and reflecting upon their own failure pedagogical mindset in action may facilitate a shift towards a more complex and interconnected space for growth and development of both educators and youth.
Malignant glomus tumor arising in association with a fumarate hydratase‐deficient leiomyoma: An unusual collision tumor
Authors: Short Emma L. , Logan Suzanna J. , Thangaiah Judith Jebastin , Folpe Andrew L. 
Published: December 2023

AbstractCollision tumors, defined as “two independent neoplasms that occur in close proximity to one another but maintain distinct boundaries,” are quite rare. We report an exceptional collision tumor composed of a genetically confirmed malignant glomus tumor and a fumarate hydratase (FH)‐deficient leiomyoma, presenting as a subcutaneous thigh mass in a 38‐year‐old male who was known to have hereditary leiomyomatosis and renal cell carcinoma syndrome. Microscopic examination identified a biphasic subcutaneous mass comprising sheets and nodules of glomus cells, with nuclear atypia and mitotic activity, and fascicles of mitotically inactive smooth muscle with variably pleomorphic nuclei and intracytoplasmic eosinophilic inclusions, features of FH‐deficient leiomyoma. Immunohistochemistry demonstrated loss of FH and robust 2‐succinocysteine expression in the smooth muscle, with a normal (FH‐retained) expression pattern in the glomus tumor. Next‐generation sequencing, performed on the glomus tumor component, identified CARMN::NOTCH2 fusion, characteristic of malignant glomus tumors. Awareness of the distinctive morphologic, immunohistochemical, and molecular genetic features of glomus tumors and FH‐deficient leiomyomas is important for correct clinical management of patients with exceptional collision tumors of this type.
Environment‐based approaches to improve participation of young people with physical disabilities during COVID‐19
Authors: Anaby Dana R. , Avery Lisa , Palisano Robert J. , Levin Mindy F. , Khayargoli Pranamika , Hsieh Yu‐Hsin , Gorter Jan Willem , Teplicky Rachel ,   BEYOND Consultant Team
Published: December 2023

AbstractAimTo examine the effects of the Pathways and Resources for Engagement and Participation (PREP) intervention during the COVID‐19 pandemic on (1) activity performance and satisfaction, and (2) motor, cognitive, and affective body functions.MethodAn interrupted time‐series design with multiple baselines across 21 young people (13 females, eight males) aged 16 to 25 years (median = 21 years 5 months) with physical disabilities was employed. The young people engaged in an 8‐week self‐chosen leisure activity (e.g. football, piano, photography) at their home or community. The Canadian Occupational Performance Measure (COPM) assessed activity performance and satisfaction weekly. Mental health problems, including affective and cognitive outcomes, were assessed weekly using the Behavior Assessment System for Children, Third Edition. Motor functions (e.g. trunk control, reaching, strength) were assessed biweekly. Linear mixed‐effects models were used.ResultsThe intervention had large effects on activity performance (0.78) and satisfaction (0.88) with clinically significant change in COPM scores (2.6 [95% confidence interval {CI}: 2.0–3.2] and 3.2 points [95% CI: 2.4–3.9] respectively). Young people without mental health problems at baseline benefited more from the intervention (p = 0.028). Improvements in at least one domain of body function occurred in 10 young people especially for motor outcomes.InterpretationResults demonstrate the effectiveness of PREP during adverse times and suggest benefits going beyond participation, involving outcomes at the body‐function level.What this paper adds

Environmental‐based interventions can improve participation even during adverse times such as the COVID‐19 pandemic.
Significant improvement with large effect sizes occurred in both activity performance and satisfaction.
Intervention was effective for all; those without mental health problems benefited more.
Improvements in body‐function outcomes were partially observed, especially in motor‐related outcomes.
Body functions may improve through participation even if not targeted by the intervention.
Predicting non‐response to intraglandular botulinum neurotoxin A injections for drooling in children with neurodevelopmental disabilities
Authors: Orriëns Lynn B. , van Hulst Karen , Willemsen Michèl A. A. P. , van den Hoogen Frank J. A. , Erasmus Corrie E. 
Published: December 2023

AbstractAimTo develop robust multivariable prediction models for non‐response to (1) submandibular botulinum neurotoxin A (BoNT‐A) injections and (2) concurrent submandibular and parotid (four‐gland) injections, to guide treatment decisions for drooling in children with neurodevelopmental disabilities, including cerebral palsy.MethodThis was a retrospective cohort study including 262 children (155 males/107 females, median age 7 years 11 months [IQR 5 years 1 month], range 4 years 0 months – 17 years 11 months) receiving submandibular injections and 74 children (52 males/22 females, median age 7 years 7 months [IQR 4 years 3 months], range 4 years 9 months – 18 years 8 months) receiving four‐gland injections. Multivariable logistic regression analyses were used to estimate associations between candidate predictors and non‐response 8 weeks after injection.ResultsNinety‐six children (37%) were non‐responders to submandibular injections, for which developmental age was the strongest predictor (adjusted odds ratio [aOR] 2.13; 95% confidence interval [CI] 1.02–4.45 for developmental age <4 years or 4–6 years with IQ <70). Other characteristics that showed a trend towards an increased risk of non‐response were diagnosis, sex, and head position. Thirty‐four children (46%) were non‐responders to four‐gland injections, for which tongue protrusion (aOR 3.10; 95% CI 1.14–8.43) seemed most predictive, whereas multiple preceding submandibular injections (aOR 0.34; 95% CI 0.10–1.16) showed a trend towards being protective. Predictors were, however, unstable across different definitions of non‐response and both models (i.e. submandibular and four‐gland) had insufficient discriminative ability.InterpretationPotential predictors of non‐response to BoNT‐A injections were identified. Nevertheless, the developed prediction models seemed inadequate for guidance of treatment decisions.What this paper adds

Developmental age seemed most predictive of non‐response to submandibular botulinum neurotoxin A injections.
Non‐response to concurrent submandibular and parotid injections was best predicted by tongue protrusion and number of previous injections.
Multivariable prediction models including these clinical characteristics were unable to discriminate well.
Predictors differed when non‐response was defined using alternative outcome measures.
Evaluation of salivary α‐amylase and immunoglobulin A responses after endurance exercise in adolescent males and females with similar aerobic fitness
Authors: Yasuda Nobuo , Tanioka Toshihiro , Nakazawa Kimitaka 
Published: December 2023

AbstractThe objective of this study was to clarify whether there are sex‐specific differences in salivary α‐amylase and immunoglobulin A responses following acute endurance exercise in adolescent males and females with equivalent cardiorespiratory fitness levels. Twenty‐six aerobically trained adolescent males and females with similar training status were enrolled in this study. Each individual executed a 1‐h prolonged cycling exercise corresponding to a constant power output at 65% of peak oxygen uptake. Unstimulated whole salivary samples were taken with the passive drooling method at the 10‐min period before and after exercise for the determination of salivary responses [α‐amylase, immunoglobulin A, total protein and flow rate]. Salivary α‐amylase activity, immunoglobulin A concentration and total protein concentration were significantly augmented immediately after acute endurance exercise. Regarding sex differences, only the salivary flow rate was significantly lower in females than in males. The findings of the present study imply that adolescent males and females appear to have similar salivary responses after acute endurance exercise, as represented by salivary α‐amylase activity and immunoglobulin A concentration in connection with total protein concentration and salivary flow rate, when they are matched for peak oxygen uptake relative to fat‐free body mass.
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study
Authors: Novitskaya Yulia , Schütz Elisa , Metternich Birgitta , Schulze‐Bonhage Andreas , Hirsch Martin 
Published: December 2023

AbstractObjectiveCenobamate, a novel antiseizure medication with a dual mechanism of action, has been shown in pivotal trials to significantly improve seizure control in treatment‐resistant focal epilepsy. We aimed to evaluate whether these promising results could be confirmed in a real‐world setting with a follow‐up period of up to 12 months.MethodsPatients from a tertiary epilepsy center who received cenobamate add‐on between June 2021 and October 2023 were followed up prospectively at 3, 6, and 12 months after treatment initiation for assessment of seizure outcomes and treatment‐related adverse events.ResultsThe clinical cohort included 112 adult patients with 30% nonlesional cases and a wide spectrum of epileptogenic lesions underlying refractory focal epilepsy. We observed a significant reduction in monthly seizure frequency of all seizure types already after 3 months of treatment at a median cenobamate dose of 100 mg/day. Forty‐six percent of patients were responders with a ≥50% seizure reduction, 26% had a ≥75% seizure reduction, and 9% became seizure‐free. Among the 74 patients with available follow‐up of 12 months, the responder rates reached 55%, 35%, and 19% for ≥50%, ≥75%, and 100% seizure reduction, respectively. After 3 months of treatment, 38% of patients reported adverse effects, mainly (84%) mild to moderate in intensity. Adjustment of comedication allowed successful management of adverse effects in 32% of patients. At a group level, there was no correlation between the cenobamate daily dose and the incidence of adverse events.SignificanceWe found a clinically relevant response to cenobamate already at a low daily dose of 100 mg also in a patient cohort with a higher degree of drug resistance than in pivotal trials. Our prospectively collected data provide real‐world evidence for high efficacy and good tolerability of the drug, although no standardized treatment protocol or comparison with a control group was applied.
Atmospheres: The multisensoriality of spatially extended emotions
Authors: Eisenlohr Patrick 
Published: December 2023

AbstractIn this essay, I introduce an analytic of atmosphere as a way to bridge the gap between the phenomenology of the felt‐body and the anthropology of the senses. This analytic of atmospheres as multisensoriality partially aligns with, but also differs from other anthropological approaches to multisensoriality or the anthropology of the senses. Examining the meaningfulness of atmospheres as spatially extended emotions from a neo‐phenomenological perspective, I argue that the notion of atmosphere offers advantages for understanding sensory cultural practices such as sounding and lighting. The felt dimensions of these practices often escape full qualification by cultural discourses, but are nevertheless deeply meaningful. Further, I explore how such atmospheric meaningfulness is irreducible to particular single sensory modi. Instead, it rests on diffuse and synesthetic kinds of felt‐bodily affectedness with a holistic character. I demonstrate this by way of two ethnographic examples, investigating practices sounding and lighting, respectively, as atmospheric practices.
Low but highly geographically structured genomic diversity of East Asian Eurasian otters and its conservation implications
Authors: Li Shou‐Hsien , Yeh Chia‐fen , Jang‐Liaw Nian‐Hong , Chang Shih‐Wei , Lin Yu‐Hsiu , Tsai Cheng‐En , Chiu Chi‐Cheng , Chen Chien‐Wen , Ke Hui‐Ru , Wang Qiaoyun , Lu Yiwei , Zheng Kaidan , Fan Pengfei , Zhang Lu , Liu Yang 
Published: December 2023

AbstractPopulations of Eurasian otters Lutra lutra, one of the most widely distributed apex predators in Eurasia, have been depleted mainly since the 1950s. However, a lack of information about their genomic diversity and how they are organized geographically in East Asia severely impedes our ability to monitor and conserve them in particular management units. Here, we re‐sequenced and analyzed 20 otter genomes spanning continental East Asia, including a population at Kinmen, a small island off the Fujian coast, China. The otters form three genetic clusters (one of L. l. lutra in the north and two of L. l. chinensis in the south), which have diverged in the Holocene. These three clusters should be recognized as three conservation management units to monitor and manage independently. The heterozygosity of the East Asian otters is as low as that of the threatened carnivores sequenced. Historical effective population size trajectories inferred from genomic variations suggest that their low genomic diversity could be partially attributed to changes in the climate since the mid‐Pleistocene and anthropogenic intervention since the Holocene. However, no evidence of genetic erosion, mutation load, or high level of inbreeding was detected in the presumably isolated Kinmen Island population. Any future in situ conservation efforts should consider this information for the conservation management units.