bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting hot electrons from a plasmon nanohybrid system for the photoelectroreduction of CO2
Authors: Sa Jacinto ,   Ananta Dey1 Ananta Dey, Silveira Vitor R. , Vadell Robert Bericat , Lindblad Andreas , Lindblad Rebecka , Shtender Vitalii 
Published: November 2023

Abstract

Plasmonic nanohybrid systems efficiently convert light into electrical charges and heat, enabling their role as mediators in catalytic transformations. While numerous instances of plasmonic photothermal catalytic reactions exist, the participation of hot carriers in these processes remains a subject of vigorous debate. In this study, we present a direct utilization of plasmon hot electrons in the photoelectrocatalytic reduction of CO2 using visible light. Through the deliberate construction of a plasmonic nanohybrid system comprising NiO/Au/ReI(phen-NH2)(CO)3Cl (phen-NH2 = 1,10-Phenanthrolin-5-amine), we demonstrate the immediate involvement of hot electrons in CO2 reduction. Supporting evidence for the engagement of hot electrons in the catalytic process is derived from ultrafast spectroscopy, in situ Fourier-transform infrared spectroscopy (FTIR), electrochemistry, and catalytic testing. Unbiased in situ spectroscopy verified the stepwise reduction of the catalytic system and the generation of CO. This, coupled with the low thermal stability of the ReI(phen-NH2)(CO)3Cl complex, explicitly establishes plasmonic hot carriers as the primary contributors to the process. Mediating catalytic reactions by plasmon hot carriers is feasible and holds promise for further exploration and development in diverse transformations with significant societal impact.
Weight control in the population with overweight and obesity: A real-world prospective cohort study
Authors: Zhu Hui , Peng Miao , Lu Chenxia , Zhang Jia , Lv Yi , Xu Xi , Huang Jingjing , Wang Jingzhi , Ouyang Kani , Xiao Mingzhong , Li Xiaodong 
Published: November 2023

Abstract

Background:
The World Health Organization defines overweight and obesity as chronic metabolic diseases that can lead to various chronic noncommunicable diseases and a reduced lifespan. However, apart from lifestyle interventions, there is currently no clear clinical evidence for the long-term efficacy of drugs and weight loss interventions in this population. Moreover, little is known about the advantages of traditional Chinese medicine interventions in patients who are overweight or obese, the population most likely to benefit from weight loss, and the factors that influence the effectiveness of weight loss. Therefore, this study explored the clinical efficacy of comprehensive traditional Chinese medicine interventions in patients who are overweight or obese.
Methods:
This prospective cohort study will prospectively collect case information and conducted a long-term follow-up of the enrolled patients. Patients who were overweight or obese patients will be recruited for long-term follow-up. This study aims to observe the effects of various exposure factors, represented by comprehensive traditional Chinese medicine interventions, on weight loss outcomes in participants who are overweight or obese. The primary outcome measure is a statistically significant weight loss of at least 5% relative to baseline. The rates of waist and hip circumference improvements and incidence of obesity-related complications will also be assessed.
Discussion:
Through a cohort study design, this project aims to achieve a long-term follow-up of patients, observe the long-term efficacy of traditional Chinese medicine, and systematically evaluate the clinical efficacy of traditional Chinese medicine through indicators such as the percentage of weight change and relapse rate. This project will elucidate the complex features of metabolic disorders using clinical-molecular network characteristics and reveal the metabolic disruption mechanisms and biological implications of different subtypes of overweight/obesity from a microbial perspective.
Trial registration:
The study was prospectively registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn ChiCTR2200063127)
The potential prognostic value of Cartilage acidic protein 1 and secretoglobin family 1D member 1 in prostate cancer
Authors: Sokhangouy Saeideh Khorshid , Asadnia Alireza , Negahbanzaferanloo Zhara , Hanaie Reyhane , Ghorbani Elnaz , Lagzian Elmira , Tabari Masoomeh , Akbarzade Hamed , Fiuji Hamid , Khazaei Majid , Hassanian Seyed Mahdi , Al-Hayawi Ibrahim Saeed , Nassiri Mohammadreza , Ferns Gordon A , Lam Alfred King-yin , Batra Jyotsna , Nazari Elham , Avan Amir 
Published: November 2023

Abstract
Background
Prostate cancer is a prevalent malignancy with a broad range of clinical outcomes, necessitating improved prognostic biomarkers for precise patient stratification and personalized treatment. This study leverages machine learning techniques to identify and validate novel prognostic biomarkers using DNAseq and RNAseq data for prostate cancer.
Methods
Whole genome sequencing and gene expression profiling in patients were used from TCGA to identify DEGs and genetic alterations. Next, deep learning was utilized to determine key genes. Gene Ontology, Reactom, GSEA, and Human Disease Ontology were employed to study the involved biological process and pathways. Survival analysis of patients with prostate cancer with reference on dysregulated genes was conducted using Cox regression and Kaplan-Meier analysis. The STRING database was used to build a protein-protein interaction (PPI) network. Moreover, candidate genes were subjected to machine learning -based analysis and the Receiver operating characteristic (ROC) curve.
Results
We identified a total of 609 DEGs in patients, of which 358 were downregulated and 251 were upregulated. Deep learning results identified 20 genes, and these were combined with the analysis of DNA-seq. Survival analysis of patients with prostatic cancer showed that dysregulated expression of ASB12, BLOC1S1, CRTAC1, KCNQ1, KISS1, M2T2A, RNF207, SCGB1D1, SLC13A2, SORBS1, TGFBR3, WSCD2, ANFKFY1, CRYBA4, MIR204, QRFP, SNX15, and YWHAH genes were related with a poor clinical prognosis. The combio-ROC curve analysis reveals ed that TGFRB3, SCGB1D1 and CRTAC1 were potential diagnostic biomarkers with a great higher sensitivity and AUC than currently available biomarkers. Also, the combination of SCGB1D1 and CRTAC1 demonstrated the greatest accuracy, sensitivity, and specificity towards diagnostic applications. The potential value of these markers was validated in six other datasets.
Conclusion
Our findings demonstrated the potential value of SCGB1D1 and CRTAC1 as novel biomarkers and therapeutic targets in prostate cancer which had a higher AUC, sensitivity, and specificity compared to PSA, indicating further functional investigations on the potential value of emerging markers in prostate cancer.
Involvement of Interlukin-17A (IL-17A) Gene Polymorphism and Interlukin-23 (IL-23) level in the Development of Peri-Implantitis
Authors: Talib Ehab , Taha Ghada 
Published: November 2023

Abstract

Background Dental implantation has been practiced since ancient times and has gone through several stages. Dentists use dental implants to support dental prostheses such as crowns, bridges, dentures, face prostheses, or as an orthodontic anchor. Thus, the purpose of this study to detect the role of the immune-genetic variation of IL-17A and related inflammatory cytokine (IL-23) in the initiation and progress of peri implantitis.Material and Methods This cross-sectional study included 80 subjects (15 peri-implantitis patients, 35 successful implants, and 30 healthy controls); their mean age was (43.91 ± 11.33) years. Blood samples were collected from all subjects (patients with peri-implantitis, successful implants, and healthy controls) attending the Department of Oral and Maxillofacial Surgery in the Dental College Teaching Hospital, Baghdad University, Baghdad, Iraq. The blood sample detects gene polymorphisms in interleukin-17A by a polymerase chain reaction. An enzyme-linked immunosorbent assay was carried out to estimate the Peri-implant sulcus fluid levels of interleukin-23.Result The current study revealed an obvious significant elevation in the mean level of interleukin-23 in the peri-implantitis patient's group more than its level in the successful implant and control groups (P˂ 0.05). In addition, the result showed that A/A genotype is associated significantly with peri-implantitis OR (95%confidence interval) = 6.9 (1.7121 to 27.4638) folds increase risk of peri-implantitis) (p = 0.0065), while G/A genotype had OR 4.9 (0.9539 to 24.9394) folds increased risk of peri-implantitis, (p = 0.0572). But it was not statistically significant and G/G genotype had a one-fold increase risk of peri-implantitis.Conclusion The increased level of inflammatory cytokine (interleukin-23) might add to the systemic inflammatory burden a predisposing factor, which may lead to impaired osseointegration and subsequent bone loss or implant failure. In addition, IL-17A gene polymorphism may play a role in peri-implant disease susceptibility, especially in persons carrying the rs2275913 A allele at a higher risk of developing peri-implantitits as compared with those carrying the G allele.
Pharmacovigilance of nephrotoxic drugs in neonates: the Pottel method for renal signal detection in ELBW neonates
Authors: Dumoulin Mathilde , Pottel Hans , Mekahli Djalila , Laenen Annouschka , Smits Anne , Allegaert Karel 
Published: November 2023

Abstract
Background
Extreme low birth weight (ELBW) neonates (birth weight ≤ 1000 grams) are at high-risk to develop drug-induced acute kidney injury (AKI). However, we lack a pragmatic detection tool to capture their time-dependent (patho)physiologic serum creatinine (Scr) patterns. Pottel et al. suggested rescaling Scr by dividing Scr with the mean Scr-value of the age and sex specific reference population. We therefore explored if this Pottel method can detect drug-related nephrotoxic signals in ELBW neonates.
Methods
A previously used dataset on Scr changes in ELBW neonates exposed to ibuprofen, amikacin or vancomycin was updated to calculate Pottel scores for every available Scr value in the first 28 postnatal days. We hereby used already published postnatal age specific 50th centile values in an ELBW population. Linear mixed models were subsequently applied, analyzing Pottel scores as response variable and continuous time (day), drug exposure, and interaction thereof in the explanatory model.
Results
3231 Scr observations in 201 ELBW neonates were collected. A statistically significant rise of Pottel scores was observed with ibuprofen treatment starting from postnatal day 4. In addition, a cumulative effect of treatment with mean Pottel scores on day 0 of 1.020 and on day 3 during treatment of 1.106 (95% CI 1.068–1.145, p < 0.001) was observed, when corrected for effect of antibiotics. Antibiotic administrations showed a small but statistical significant difference up to postnatal day 5.
Conclusions
As rescaled Scr biomarker, the Pottel method showed a clear signal in ibuprofen-exposed ELBW neonates, suggesting its applicability as pragmatic bedside tool to assess nephrotoxicity.
Comparing Clomiphene-Primed Ovarian Stimulation and Mid-Luteal GnRH Agonist Protocols: A Cumulative Live Birth Rate and Cost-Effectiveness Analysis in a Single- Center Retrospective Study with Propensity Score Matching
Authors: Li Yanhui , Luo Dan , Li Tao , Ding Hui , Liu Yi 
Published: November 2023

Abstract
The decline in assisted reproductive technology (ART) success among older women, attributed to decreased oocyte quantity and quality, poses a significant challenge. Currently, no consensus exists on the optimal ovarian stimulation protocol for older women undergoing IVF. This retrospective registered cohort study aimed to compare cumulative live birth rates (CLBR), time to live birth (TTLB), and cost-effectiveness in women over 35 years using gonadotropin-releasing hormone agonist (GnRHa) or clomiphene-primed ovarian stimulation (CPOS). We performed propensity score matching (PSM) on 2,871 IVF cycles in women over 35 who received either GnRHa or CPOS protocols, resulting in 375 cycles in each group to compare treatment outcomes. Additionally, a decision tree model was utilized to assess the cost-effectiveness of the two protocols. Following PSM, both groups showed similar baseline characteristics. The CPOS protocol exhibited a higher cycle cancellation rate (13.07% vs 8.00%, p=0.032), yet maintained comparable fertilization and embryo quality. While CLBRs per initial cycle (41.07% vs. 45.33%, p=0.269) and delivery outcomes were similar between the groups after a 24-month follow-up, TTLB was longer in the CPOS group. Notably, the average cost per live birth in the CPOS group was 21.27% less than that in the GnRHa group (￥32,301.42 vs ￥ 39,174.22). In conclusion, for women over 35 undergoing IVF, the CPOS protocol demonstrated similar CLBR to GnRHa but with lower costs, suggesting its potential as a viable and cost-efficient ovarian stimulation option.
Clinical trial registration
https://www.chictr.org.cn/, identifier [ChiCTR2300076537].
Clinical Features and Vaccine Efficacy Analysis of COVID-19 patients in a Chongqing Shelter hospital in 2022
Authors: luo yining , Zhao Mei , Zhao Xingyu , Qiao Yanwen , Wu tingting , Gao Yanxia , Liu Weiwei , Ren Yi 
Published: November 2023

Abstract
Background
The long-term impact of coronavirus disease 2019 (COVID-19) on many aspects of society emphasizes the necessity of vaccination and nucleic acid conversion time as markers of prevention and diagnosis. However, little research has been conducted on the immunological effects of vaccines and the influencing factors of virus clearance. Epidemiological characteristics and factors related to disease prognosis and nucleic acid conversion time need to be explored.
Design and participants:
We reviewed published documentation to create an initial draft. The data were then statistically evaluated to determine their link. Given that a Chongqing shelter hospital is typical in terms of COVID-19 patients receiving hospital management and treatment effects, a retrospective analysis was conducted on 4,557 cases of COVID-19 infection in a shelter hospital in Chongqing in December 2022, which comprised 2,291 males and 2,266 females. The variables included age, medical history, nucleic acid conversion time, vaccination status, and clinical symptoms.
Results
Univariate survival analysis using the Log-rank test (P < 0.05) showed that factors such as age significantly affected nucleic acid conversion time. COX regression analysis indicated a significant association between a history of hypertension and nucleic acid conversion time, which had a hazard ratio of 0.897 (95% CI: 0.811–0.992). A statistically significant difference was observed between vaccinated and unvaccinated infected individuals in terms of the presence of symptoms such as cough and sensory system manifestations (P < 0.05).
Conclusion
The effect of vaccination against COVID-19 on symptoms such as coughing, nasal congestion, muscle aches, runny nose, and sensory system symptoms in COVID-19 patients was determined. Typical symptoms, such as runny nose, were generally higher in vaccinated than in unvaccinated ones; previous hypertension was an influential factor in nucleic acid conversion time in patients with COVID-19 infection.
Exploring Challenges in Accessing Primary Healthcare for Pregnant Women in Pakistan: A Qualitative Descriptive Study
Authors: Khan Bushra Asif Ali , Mahmood Humaira , Ahmed Jawaria Mukhtar , Anwar Bushra , Muhammad Ameer , Jabeen Rawshan 
Published: November 2023

Abstract
Introduction: Maternal and newborn mortality are pressing global health concerns, with the Sustainable Development Goal 3.8 (SDGs) aiming to improve these outcomes however the poor quality of care in health facilities is a significant barrier to utilizing ANC services in Pakistan. Thus, this study aimed to understand the barriers to the underutilization of antenatal care (ANC) services in Tehsil Hazro, Punjab, Pakistan, from the perspective of pregnant women.
Method: The study employed four focus group discussions (FGDs) with 36 pregnant women who had attended at least three ANC visits. Data was collected through purposive sampling and analyzed using Nvivo 12, maintaining rigor through Guba and Lincoln's principles.
Result: The findings revealed three key themes. First, women often made the decision to seek care with support from their spouse, family, and lady health workers, emphasizing the importance of their decision-making autonomy. Financial constraints did not deter them from accessing healthcare services. Second, delays in reaching healthcare facilities were attributed to long distances, travel time, and associated costs. Additionally, women lacked awareness of danger signs and the importance of timely medical help. Lastly, delays in receiving quality care were linked to the unavailability of healthcare personnel, staff attitudes, insufficient medicines and equipment, and a lack of referral services.
Conclusion: In conclusion, this descriptive study underscores the necessity of providing affordable, accessible, and responsive maternal and child healthcare. To address these issues, stakeholders, including policymakers, the Ministry of Health, public health experts, and maternal, neonatal, and child health (MNCH) providers, must prioritize MNCH initiatives and reforms. Their collaborative efforts are vital for translating MNCH policies into effective community-level strategies.
Turbulent Flow across a clearing-forest transition: A Large Eddy Simulation Study
Authors: Pinheiro Luis Aramis dos Reis , Mendes Rafael Castilho Faria , de Siqueira Mário Benjamim Baptista , Brasil Antônio Cesar Pinho 
Published: November 2023

Abstract
Forest fragmentation leads to changes in scalar concentration and momentum fluxes. These changes create superficial heterogeneity in forests, affecting mass, energy, and meteorological flows across various spatial scales. The abrupt alteration of canopy roughness from clearing-to-forest wind flow triggers instabilities downstream of the forest border, revealing the significant contribution of advective flows.
Current methodologies investigate canopy flows with idealized foliage distribution, using the same Leaf Area Index as the experimental data. In these experiments, leaf density is typically higher near the top of the canopy. To simulate clearing-to-forest wind flow, we employ Large Eddy Simulation (LES) with momentum drag dependent on foliage density. The maximum value of this drag occurs at the middle of the forest height (0.5h). Our results demonstrate a well-adjusted turbulent profile downstream of the forest. Near the border, increased skewness at the top and in the middle of the canopy indicates a large variability in the wind field. At the top of the canopy, we find maximum vertical momentum fluxes, and at z=0.5h, positive values indicate downward fluxes. Within the canopy, the dominant structures are sweeps, representing gust events responsible for momentum flux transport from the wind to the forest. Despite the profiles being well-resolved in the clearing and deep into the forest, close to the border, high levels of turbulence create instabilities, increasing uncertainty in LES simulations. To address this, it is necessary to refine the clearing fetch dimension and inflow boundary conditions.
WITHDRAWN: Behavioral strategies of actors in food safety social co-governance: Analysis of a four-party evolutionary game
Authors: WU Linhai 
Published: November 2023

Abstract

Effective food safety governance relies on a social co-governance system involving multiple actors coordinating with each other. In this system, social forces composed of news media and consumers, and so on are a third-sector force that corrects government and market failures. Accordingly, this study constructs a model for the four-party evolutionary game among food companies, government agencies, news media, and consumers. The system equilibrium points are calculated and verified by Matlab numerical simulation. In addition, the impact of changes in behavioral strategies by each actor on the system evolution path is investigated. The results show that the four-party game system has three equilibrium points: {safe production, strict regulation, no coverage, participation in co-governance}, {risky production, strict regulation, coverage, participation in co-governance}, and {safe production, strict regulation, coverage, participation in co-governance}. If the input costs of government agencies exceed a critical value, the agencies will be unable to afford the high regulatory costs and have reduced motivation for strict regulation; consequently, food companies will tend to adopt risky production behaviors. The probability of food companies adopting safe production behaviors increases with the increased probability of media coverage being true. Media coverage with a low probability of being true has no deterrent effect on corporate violations. Moreover, it may even hinder regulation by government agencies by increasing the cost to verify the coverage, thus resulting in increased corporate violations. Therefore, government agencies need to improve the regulatory model and consumer rights protection mechanism to reduce the costs of strict regulation and media coverage investigation. It is also important to enhance the regulation of news media to ensure accurate coverage. In addition, government agencies need to provide consumers with optimal incentives to encourage their participation in co-governance, which also helps control the cost of government regulation.
Replenishment of Drosophila Male Pheromone After Mating
Authors: FERVEUR JEAN-FRANÇOIS , CORTOT JÉRÔME , MOUSSIAN BERNARD , COBB MATTHEW , EVERAERTS CLAUDE 
Published: November 2023

Abstract
Insects exocrine gland products can be involved in sexual communication, defense, territory labelling, aggregation and alarm. In the vinegar fly Drosophila melanogaster the ejaculatory bulb synthesizes and releases 11-cis-Vaccenyl acetate (cVa). This pheromone, transferred to the female during copulation, affects aggregation, courtship and male-male aggressive behaviors. To determine the time-course of cVa replenishment, males of a control laboratory strain and from the desat1 pheromone-defective mutant strain were allowed to mate successively with several females. We measured mating frequency, duration and latency, the amount of cVa transferred to mated females and the residual cVa in tested males. Mating duration remained constant with multiple matings, but we found that the amount of cVa transferred to females declined with multiple matings, indicating that, over short, biologically-relevant periods, replenishment of the pheromone does not keep up with mating frequency, resulting in the transfer of varying quantities of cVa. Adult responses to cVa are affected by early developmental exposure to this pheromone; our revelation of quantitative variation in the amount of cVa transferred to females in the event of multiple matings by a male suggests variable responses to cVa shown by adults produced by such matings. This implies that the natural role of this compound may be richer than suggested by strictly-controlled laboratory experiments.