bluuebunny/crossref_metadata_2025_split huggingface dataset:
DYNAMICS OF CHANGES IN FUNCTIONAL LIMITATIONS AND ACTIVITY OF THE UPPER EXTREMITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER THE INFLUENCE OF REHABILITATION TECHNOLOGY
Authors: Nogas A.O. 
Published: October 2023

Резюме. Питання відновного лікування із застосуванням реабілітаційних заходів є надзвичайно важливим для пацієнтів з ревматоїдним артритом з метою покращення функціональної активності верхніх кінцівок, досягнення тривалої ремісії та покращення якості життя.
Мета роботи – оцінити ефективність технології реабілітаційних заходів за оцінкою функціональних обмежень та активності верхніх кінцівок пацієнтів з ревматоїдним артритом з використанням опитувальника DASH.
Матеріал і методи. У дослідженні взяли участь 188 пацієнтів з ревматоїдним артритом. Всі хворі були розподілені методом рандомізації на контрольну (n=92) та основну (n=96) групи. Пацієнти контрольної групи проходили реабілітацію відповідно до протоколу МОЗ України. Хворі основної групи займалися за запропонованою технологією реабілітаційних заходів, що містила наступні елементи: терапевтичні вправи, лікувальний масаж, фізіотерапію, гідротерапію, ортезування, кінезіотейпування верхніх кінцівок, механотерапію та психологічну підтримку пацієнта. Для оцінки функціональних обмежень та активності верхніх кінцівок застосовували опитувальник DASH.
Результати. За оцінкою результатів опитувальника DASH пацієнти обох груп 73,9% зазначили, що найбільші труднощі у них виникали при виконанні побутових дій, зокрема тих, що потребують сили кисті. Засоби фізичної терапії, які були включені до розробленої технології реабілітаційного втручання, сприяли відновленню функціональної активності верхніх кінцівок у виконанні побутових дій пацієнтів основної групи. Результати показників опитувальника DASH в основній групі достовірно перевищують показники контрольної групи, що підтверджує ефективність впроваджених реабілітаційних заходів.
Висновки. Розроблена технологія реабілітаційного втручання сприяла покращенню показників пацієнтів основної групи, що характеризують домен активності та участі за МКФ, на що вказують результати опитувальника DASH.
Ключові слова: ревматоїдний артрит, опитувальник DASH, функціональні обмеження верхніх кінцівок, технологія реабілітаційних заходів.
Quality of Digital Health Interventions Across Different Health Care Domains: Secondary Data Analysis Study
Authors: Hyzy Maciej , Bond Raymond , Mulvenna Maurice , Bai Lu , Dix Alan , Daly Robert , Frey Anna-Lena , Leigh Simon 
Published: October 2023

Background
There are more than 350,000 digital health interventions (DHIs) in the app stores. To ensure that they are effective and safe to use, they should be assessed for compliance with best practice standards.

Objective
The objective of this paper was to examine and compare the compliance of DHIs with best practice standards and adherence to user experience (UX), professional and clinical assurance (PCA), and data privacy (DP).

Methods
We collected assessment data from 1574 DHIs using the Organisation for the Review of Care and Health Apps Baseline Review (OBR) assessment tool. As part of the assessment, each DHI received a score out of 100 for each of the abovementioned areas (ie, UX, PCA, and DP). These 3 OBR scores are combined to make up the overall ORCHA score (a proxy for quality). Inferential statistics, probability distributions, Kruskal-Wallis, Wilcoxon rank sum test, Cliff delta, and Dunn tests were used to conduct the data analysis.

Results
We found that 57.3% (902/1574) of the DHIs had an Organisation for the Review of Care and Health Apps (ORCHA) score below the threshold of 65. The overall median OBR score (ORCHA score) for all DHIs was 61.5 (IQR 51.0-73.0) out of 100. A total of 46.2% (12/26) of DHI’s health care domains had a median equal to or above the ORCHA threshold score of 65. For the 3 assessment areas (UX, DP, and PCA), DHIs scored the highest for the UX assessment 75.2 (IQR 70.0-79.6), followed by DP 65.1 (IQR 55.0-73.4) and PCA 49.6 (IQR 31.9-76.1). UX scores had the least variance (SD 13.9), while PCA scores had the most (SD 24.8). Respiratory and urology DHIs were consistently highly ranked in the National Institute for Health and Care Excellence Evidence Standards Framework tiers B and C based on their ORCHA score.

Conclusions
There is a high level of variability in the ORCHA scores of DHIs across different health care domains. This suggests that there is an urgent need to improve compliance with best practices in some health care areas. Possible explanations for the observed differences might include varied market maturity and commercial interests within the different health care domains. More investment to support the development of higher-quality DHIs in areas such as ophthalmology, allergy, women’s health, sexual health, and dental care may be needed.
Connected Health Requirements Gathering for ADHD Through Clinical Journey Mapping (Preprint)
Authors: Harris Richard , Adam Frederic , Murray Deirdre , McSweeney Angela 
Published: October 2023

BACKGROUND

The creation of a robust connected health application, by its very nature, requires a multidisciplinary development team. Integrated patient journey mapping presents a fantastic opportunity to streamline the requirements gathering process by clearly illustrating the patient journey to individuals who are not familiar with the clinical practice. However, there are limitations to integrated patient journey mapping, particularly the size of the diagrams themselves which often require specialized equipment to adequately present [1]. This research has focused on ADHD as a case study for implementing Clinical Journey Mapping, with the Dundee Clinical Care Pathway [2] identified as the gold standard for ADHD treatment and thus used as the preferred patient journey template.

OBJECTIVE

The objective for this paper will be to answer the following research questions:

1)	How can the Dundee Clinical Care Pathway be visualized on the Integrated Journey Mapping tool?
2)	How can the Integrated Journey Mapping Tool be updated in order to improve its accessibility?
3)	Is visualizing the Dundee clinical care pathway beneficial to stakeholders when identifying key requirements for a connected health application designed to support
the implementation of the pathway?

METHODS

This study has utilized a design science approach [3] where a sample artifact is presented to a relevant audience for review and feedback, which is then leveraged to iterate the artefact. This paper has leveraged both Information Systems professionals and clinical professionals to achieve relevant feedback for each iteration.

RESULTS

The implementation of the above methods has resulted in the creation of a clinical patient journey map which highlights multiple persona journeys through the Dundee clinical care pathway on one diagram. Utilizing UML concepts and color coding, multiple patient personas can be mapped onto a streamlined diagram, allowing the diagram to be used in a wider variety of situations.

CONCLUSIONS

Based on feedback from participants, the following recommendations for where connected health can be embedded within the Dundee clinical care pathway are presented:

1)	Leverage software-based screening questionnaire to reduce face to face clinician time.
2)	Utilized software-based teaching materials, including digital content libraries using text, audio and/or video, to assist in the non-medical intervention stages of
the pathway.
3)	Adopt smart remote monitoring tools, for example Bluetooth blood pressure cuffs, to streamline the continued care process with the aim of reducing the number of
required continued care appointments while maintaining a high level of oversight and care for patients.
Analysis The Effectiveness of E-Court System at The Religious Court of Bangil Based on Simple Principles Quickly and Low Cost
Authors: Sakinah Nur Ainun 
Published: October 2023

A system can be declared successful if its application in the field has achieved predetermined objectives. The Supreme Court as the highest agency in the judicial sphere has issued a system to register cases and trials in court electronically, one of which is the Bangil Religious Court. The purpose of the study was to determine the application of the e-court system in the examination of cases at the Bangil Religious Court and to determine the effectiveness of the e-court system at the Bangil Religious Court. Research methods used by researchers are sociological empirical research methods that describe the actual environmental conditions of society supported by data and facts obtained by conducting interviews and observations. The results showed that: 1) The examination of cases at the Bangil Religious Court has not fully implemented the examination of cases using the e-court system because one of the agendas for examining cases in the trial, namely the agenda of evidence, is still carried out manually. 2) Effectiveness of e-court system implementation The Bangil Religious Court cannot run effectively because 4 factors of legal effectiveness cannot be met, namely Law Enforcement Factors there are obstacles experienced by judges in the verification process in the e-court system, Facilities and Infrastructure Factors related to network system constraints from the center and facilities that are less attractive to the community, Community Factors that do not understand technological developments, Cultural Factors The difficulty of transitioning people's way of life from conventional to electronic. The factor that is fulfilled is Law Enforcement Factors evidenced by the issuance of PERMA Number 1 of 2019. Suggestion that the Supreme Court improve network repair and maintenance on the e-court system to avoid system errors at certain times and often conduct socialization related to e-court renewal.
Effects of wind shear and aerosol conditions on the organization of precipitating marine stratocumulus clouds
Authors: Jeong Jong-Hoon , Witte Mikael K , Smalley Mark 
Published: October 2023

This study examines how wind shear affects precipitating marine
stratocumulus clouds under different cloud droplet number concentrations
(N). We performed a series of large eddy
simulations (LES) of nocturnal marine stratocumulus clouds using Cloud
Model 1 (CM1). The simulations show that N is
the dominant factor for cloud cellular organization in this cloud regime
rather than wind shear. Low N characterizes the
open cellular structure with a high in-cloud liquid water path (LWP).
When wind shear is increased, the cloud fraction tends to decrease along
with LWP, suggesting the cloud top region is significantly influenced by
the entrainment and mixing of dry air from the free troposphere. We also
examine cold pools in open and closed cellular clouds. Open-cell clouds
produce larger and deeper cold pools compared to closed-cell clouds.
Interestingly, cold pools can exist without surface precipitation and
are produced by evaporation of light precipitation (drizzle) below the
cloud base with weak downdrafts. The evaporation of raindrops and
drizzle play an important role in initiating new convection,
particularly where colliding outflows occur downstream of the cloud.
This secondary convection contributes to the development and maintenance
of the cloud cellular organization and formation.
Unsupervised Learning of Sea Surface Height Interpolation from Multi-variate Simulated Satellite
Authors: Archambault Théo , Filoche Arthur , Charantonis Anastase , Béréziat Dominique , Thiria Sylvie 
Published: October 2023

Satellite-based remote sensing missions have revolutionized our
understanding of the Ocean state and dynamics. Among them, spaceborne
altimetry provides valuable measurements of Sea Surface Height (SSH),
which is used to estimate surface geostrophic currents. However, due to
the sensor technology employed, important gaps occur in SSH
observations. Complete SSH maps are produced by the altimetry community
using linear Optimal Interpolations (OI) such as the widely-used Data
Unification and Altimeter Combination System (DUACS). However, OI is
known for producing overly smooth fields and thus misses some
mesostructures and eddies. On the other hand, Sea Surface Temperature
(SST) products have much higher data coverage and SST is physically
linked to geostrophic currents through advection. We design a realistic
twin experiment to emulate the satellite observations of SSH and SST to
evaluate interpolation methods. We introduce a deep learning network
able to use SST information, and a trainable in two settings: one where
we have no access to ground truth during training and one where it is
accessible. Our investigation involves a comparative analysis of the
aforementioned network when trained using either supervised or
unsupervised loss functions. We assess the quality of SSH
reconstructions and further evaluate the network’s performance in terms
of eddy detection and physical properties. We find that it is possible,
even in an unsupervised setting to use SST to improve reconstruction
performance compared to SST-agnostic interpolations. We compare our
reconstructions to DUACS’s and report a decrease of 41\%
in terms of root mean squared error.
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis
Authors: Wang Dongdong , Jabile Maria Joy Therese , Lu Junfeng , Townsend Logan K. , Valvano Celina M. , Gautam Jaya , Batchuluun Battsetseg , Tsakiridis Evangelia E. , Lally James S.V. , Steinberg Gregory R. 
Published: October 2023

In contrast to the well-defined biological feedback loops controlling glucose, the mechanisms by which the body responds to changes in fatty acid availability are less clearly defined. Growth differentiating factor 15 (GDF15) suppresses the consumption of diets high in fat but is paradoxically increased in obese mice fed a high-fat diet. Given this interrelationship, we investigated whether diets high in fat could directly increase GDF15 independently of obesity. We found that fatty acids increase GDF15 levels dose dependently, with the greatest response observed with linolenic acid. GDF15 mRNA expression was modestly increased in the gastrointestinal tract; however, kidney GDF15 mRNA was ∼1,000-fold higher and was increased by more than threefold, with subsequent RNAscope analysis showing elevated expression within the cortex and outer medulla. Treatment of wild-type mice with linolenic acid reduced food intake and body mass; however, this effect disappeared in mice lacking the GDF15 receptor GFRAL. An equal caloric load of glucose did not suppress food intake or reduce body mass in either wild-type or GFRAL-knockout mice. These data indicate that fatty acids such as linolenic acid increase GDF15 and suppress food intake through a mechanism requiring GFRAL. These data suggest that a primary physiological function of GDF15 may be as a fatty acid sensor designed to protect cells from fatty acid overload.

Article Highlights
The mechanisms by which the body responds to changes in fatty acid availability are less clearly defined. We investigated whether diets high in fat could directly increase growth differentiating factor 15 (GDF15) independently of obesity. Fatty acids increase GDF15 and reduce food intake through a GFRAL signaling axis. GDF15 is a sensor of fatty acids that may have important implications for explaining increased satiety after consumption of diets high in fat.
Review on Technologies Applied to Classification of Tomato Leaf Virus Diseases
Authors: Okengwu Ugochi A. , Akpughe Hillard A. , Odogu Eyinanabo , Ojetunmibi Taiye 
Published: October 2023

Tomato leaf virus diseases present a significant risk to tomato cultivation, leading to substantial financial losses worldwide. Implementing appropriate control measures depends on these diseases being accurately and quickly identified and classified. This article provides an insight into the analysis of the various technologies used to classify tomato leaf virus diseases as well as some similar plant leaf virus disease. The review encompasses both traditional and modern techniques, including image processing, machine learning, and deep learning methods. It explores the use of different imaging techniques, such as visible light RGB, infrared, and hyperspectral imaging, for capturing leaf disease symptoms. Additionally, it emphasizes the growing significance of deep learning models, such as convolutional neural networks, in identifying diseases with extreme precision. Overall, this study offers insightful information on the technological developments for the categorization of tomato leaf viral illnesses, promoting the creation of efficient disease management techniques.
La importancia de la estimulación sensorial en el desarrollo cognitivo: Un análisis documental y de campo
Authors: Rosales Marco , Revelo Priscila , Guijarro Johanna 
Published: October 2023

La estimulación sensorial se ha convertido en el pilar fundamental para que los niños posean un mejor desarrollo. Por ello, la presente investigación tiene como propósito analizar el desarrollo cognitivo a través de la estimulación temprana sensorial motora en la primera infancia.
La metodología utilizada sigue un enfoque cuantitativo de carácter documental y de campo, de corte transversal no experimental. La técnica utilizada para recolectar datos primarios fue la encuesta, aplicada a 90 docentes de Inicial I y II de diferentes establecimientos.
Los hallazgos manifiestan que una buena estimulación y la aplicación de estrategias adecuadas lograran un aprendizaje adecuado en el niño; además, expresa la necesidad de que los infantes reciban en edades tempranas una suficiente estimulación sensorial para desarrollar su área cognitiva.
Se concluye que existe una correlación entre el desarrollo cognitivo en la primera infancia, la influencia del entorno familiar y la estimulación sensorial; y se subraya la importancia de implementar programas de intervención temprana y estrategias educativas centradas en la sensorialidad para promover el desarrollo cognitivo en los niños.
The role of foreign-owned entities in building economic resili-ence in times of crisis: The case of European digital and technologically-intensive firms during the Covid-19 pandemic
Authors: Umiński Stanisław , Nazarczuk Jarosław M. , Borowicz Aleksandra 
Published: October 2023

Research background: Over the decades, foreign-owned entities (FOEs) have become an important part of the economic landscape considered as behemoths of globalisation, but also transmitters of positive effects such as technology or know-how spillovers. In times of volatility and uncertainty, firms’ contribution to building a resilient economy is at the top of the public agenda. Purpose of the article: The purpose of the article is two-fold. Firstly, we test, how FOEs perform in this stressful time of volatility and uncertainty. Secondly, we examine the contribution to resilience by digital and technologically intensive sectors. Methods: The study utilises the Bureau van Dijk (BvD) Orbis firm-level database as a primary data source. The results are derived with the use of two econometric approaches. Firstly, we estimate a static model utilising the ordinary squares estimator. Secondly, we re-estimate the equations using a two-step System GMM estimator. It introduces a lagged dependent variable into the model and implements a correction for endogeneity among covariates by including instruments (in levels and differences). Findings & value added: We use size, age, ownership, gearing, and intangibility as firms’ financial performance determinants, together with the sector-, country- and time-fixed effects. FOEs compared to domestic ones generated a higher revenue growth rate. In times of crisis high-tech and digital firms are more resilient. However, ownership does not matter in this respect. We contribute to the discussion about functions performed by FOEs in crisis and turbulent times, in which resilience issues are on top of the agenda. Our research intends to bridge the gap between the performance of FOEs, micro-level analysis, and resilience.
The impact of corporate reputation and social media engagement on the sustainability of SMEs: Perceptions of top managers and the owners
Authors: Dvorský Jan , Bednarz Joanna , Blajer-Gołębiewska Anna 
Published: October 2023

Research background: Small and medium-sized enterprises (SMEs) play a fundamental role in countries’ economies. Currently, entrepreneurs are struggling not only with the uncertainty of the business environment, but also with high expectations for businesses to be run in a sustainable way. Therefore, the impact of corporate reputation and social media on sustainability is an area of interest for entrepreneurs. In this context, little research has been conducted on their perception of the linkage between these issues. Furthermore, there has been no direct explanation of the effects of SMEs’ reputation and social media usage on their sustainable development, especially in the V4 countries.
Purpose of the article: This article defines, quantifies, and verifies the effects of corporate reputation and social media on sustainable development as perceived by SMEs’ owners and top managers in the V4 countries.
Methods: Data were gathered in December 2022 and January 2023 using the computer-assisted web interviewing (CAWI) method. The survey was designed based on a literature review and experts’ opinions. Respondents (top managers of SMEs, n = 1090) were asked questions on their firms’ characteristics, reputation, social media usage and sustainable development. The linear regression modelling (LRM) was utilised to evaluate the hypothesis.
Findings & value added: The study revealed a strong relationship between owners’ and top managers’ perceptions of the importance of both corporate reputation and sustainable development in SMEs. The belief that social media supports the growth of companies’ performance is related to the understanding of the concept of sustainable business development. Surprisingly, for the owners and top managers of SMEs in V4 countries, there was no relationship between the awareness of social media usage to share information with customers and partners and the understanding of sustainable business growth.
Kinetic modelling for COD and nitrate-N removal from hatchery wastewater through biological approach
Authors: Zainol Norazwina , Aziz Nor Hazwani , Mohamed Nor Rahim Nur Husnina 
Published: October 2023

This study was conducted to determine the nutrient removal efficiency via the application of mixed cultures from the synthetic hatchery wastewater based on the first-order, second-order and Stover Kincannon models. The synthetic wastewater was prepared according to the characterization of the collected hatchery wastewater sample, and the collected mixed cultures from the pond sediment were acclimatized accordingly. The samples were tested for chemical oxygen demand (COD) and nitrate-N concentration using a Hach spectrophotometer to determine the removal value of the nutrients. The findings show that the highest removal percentage for COD was up to 31.35% on day 3. Meanwhile, the highest removal percentage for nitrate-N was obtained on day 4 at 43.48%. The obtained correlation coefficient, for COD through first-order, second-order, and Stover Kincannon models is 1, 0.6774, and 0.965, respectively, suggesting that the kinetics of COD removal can be described most properly by the first-order model. A similar model was also reported for nitrate-N with value of 1, 0.7563, and 0.8693 for the first-order, second-order, and Stover Kincannon models, respectively. Based on the findings, the acclimatized mixed culture used in this study could be a potent natural COD and nitrate-N removal in the hatchery wastewater.