bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicentre, randomized, double blind, placebo controlled pilot study to evaluate the efficacy and safety of colloidal Nano silver gel (SilverSol) in the treatment of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis
Authors: Mehta Anirudh , Dani Saurabh , Godbole Alaka 
Published: February 2024

The study evaluated the efficacy and safety of colloidal nano silver gel (SilverSol Vagigel) (A patented technology from American Biotech Labs, USA) in combination with 0.2% lactic acid in the female subjects for the treatment of vaginal infections.This study was a multicenter, randomized, double-blind, placebo-controlled pilot study in which post-menarchal female subjects between 18 and 65 years of age clinically diagnosed with bacterial vaginosis and vulvovaginal candidiasis were enrolled. The participants were randomized to receive treatment with SilverSol Vagigel or placebo (vehicle) gel (both treatments as one 4 gm application inserted into the vagina with an applicator device, once daily at bedtime for internal use and 2 gm gel for local application to the vulva and vagina for external use twice daily for a period of 14 days). The primary endpoint evaluated was the proportion of subjects achieving clinical cure. The secondary endpoint was the proportion of subjects achieving microbiological cure at the end of the study visit. A total of 57 subjects were randomized in the study out of which 38 subjects were randomized in SilverSol Vagigel arm and 19 subjects were randomized in placebo arm. SilverSol Vagigel significantly improved cure rates of vaginal infections compared to placebo. The proportion of subjects achieving clinical cure of vaginal infections was higher i.e., 33 (86.84%) subjects in SilverSol Vagigel arm compared to 07 (41.18%) subjects in Placebo gel arm (p-value: 0.0009). The clinical cure rate with SilverSol Vagigel was 81.82% (P=0.1758) for bacterial vaginosis and 92.59% (P=0.0010) for vulvovaginal candidiasis patients at the end of the study. Overall SilverSol Vagigel treatment resulted in a significantly higher microbial cure of vaginal infections (P=0.0028) compared to placebo, with a microbial cure rate of 100% for bacterial vaginosis (P=0.0330) and 85.19% for vulvovaginal candidiasis (P=0.0097). No adverse events were reported in subjects treated with SilverSol Vagigel.Colloidal Nano Silver Gel (SilverSol Vagigel) was effective and safe in treating bacterial vaginosis and vulvovaginal candidiasis.
Biology teaching that develops the metacognitive aspect of learning: How to learn competence
Authors: Labak Irena , Maruncek Ivona , Blazetic Senka 
Published: February 2024

Higher-order thinking and metacognition are closely related and are part of learning to develop competence. The goal of this research was to determine the practice of teaching biology that develops metacognition and evaluate whether teachers require specific professional training for this purpose or if broader cognitive-focused training can also enhance metacognitive development in students. The original Teaching Observation Form (TOF) has been adapted for research objectives. A survey was designed to capture the subjective perspectives of 292 students and their teachers regarding metacognition development. Additionally, the research involved six biology teachers who were professionally trained in a program focused on higher-order thinking. The survey results indicate a self-assessed good teaching practice for the development of metacognition. However, analysis of the first lesson's video recordings showed that some components had been eliminated from biology classes which hindered students' ability to develop metacognition. Although higher-order thinking and metacognition are interconnected phenomena, professional development training focuses solely on higher-order thinking whose impact we established through analysis of other lessons does not induce the necessary positive changes for the comprehensive development of metacognition in students. In a nutshell, explicit professional development programs aimed at fostering metacognitive awareness among teachers need to be designed. These programs should instruct teachers on how to model the development of metacognition in students through their teaching.
Cuerva, Maria of Austria, Holy Roman Empress (1528-1603): Dynastic Networker (London: Routledge, 2021)
Authors: Lee Stolička Ondřej 
Published: February 2024

Review of Maria of Austria, Holy Roman Empress (1528-1603): Dynastic Networker. By Rubén González Cuerva. London: Routledge. 2021. ISBN 978-0-367-64660-8. xiv + 308 pp. £120.
Identifying relationships between landscape values, spatial perceptions of risk, and physical assets
Authors: Johnson Malcolm S. , Adams Vanessa M. , Byrne Jason 
Published: February 2024

Abstract

Effective adaptation to climate risks requires identifying and realizing community beliefs about which locations require management attention. Environmental planners and asset managers, especially those in rural and regional areas, often struggle to engage with community sentiments about place or to incorporate those feelings into decision-making processes. This study measures the associations between spatial perceptions of climate change risks and spatially assigned landscape values to support adaptation prioritization. Using public participation geographic information systems data collected via an online survey in Southern Tasmania, we identify factors influencing mapping behavior, finding correlations between values, risks, and physical assets. Results from linear regression and spatial-cross correlation indicate that spatial perceptions of risk are strongly associated with landscape values. Additionally, mapped values and risks demonstrate novel associations with select on-ground assets (e.g., towns and protected areas). The highest-ranked perceived risks were Bushfire, Sea-level rise, and Biodiversity loss/change. Considering associations between landscape values and risks, Recreation and Wilderness values associated with Bushfire and variable relationships with Sea-level rise (strong for Recreation and weak for Wilderness). Intercorrelations between social-psychological influencing factors, values, and risks returned inconclusive results warranting further research. The approach described in this research has the potential to inform climate adaptation planning by categorizing key locations that require management action, potential areas likely leading to community resistance, and the underlying sentiments that inform landscape values and spatial perceptions of risk more broadly.
Challenges of Transdisciplinary Approach in Disaster Recovery Management
Authors: Takeuchi Kuniyoshi , Mangada Ladylyn 
Published: February 2024

Abstract
Disaster risk reduction is critical in building a sustainable, resilient and inclusive society. Achieving such a society necessitates a transdisciplinary approach (TDA), that is, good governance with scientific knowledge-based decision making involving all related people in all disciplines and sectors working together. Need of such TDA has been well recognized in United Nations (UN) declarations and national laws but the case studies of disaster recovery processes of Ormoc and Tacloban, the Philippines revealed that the reality was not necessarily satisfactory nor encouraging in its implementation. Critical governance issues were found in such areas as coordination between central and local governments, residential participation, personnel continuity, information sharing, intra-governmental collaboration at emergency, lack of meaningful participation of researchers in decision making process etc. Necessities were identified institutional challenges such as transparency in decision making processes, laws to legally bind coordination, administrative structure to organize cross sectoral and disciplinary committees, efficient information flow, fostering community leaders, competitive points to researchers for practical contributions to society etc.
Spatial and temporal distribution of cystoliths in mulberry leaves and their formation under the influence of phytohormones 6-BA and ABA
Authors: Yang Chao , Zhang Qi , Qian Peng , Liang Jiubo , Chen Lin , Yuan Jianglian , He Ningjia 
Published: February 2024

Abstract
Mulberry (Morus spp.) has been studied to gain insight into cystolith formation, which is primarily composed of calcium carbonate (CaCO3) crystals and commonly found in mulberry leaves. However, the effects of phytohormones on cystolith formation in mulberry and the origin of carbon within these structures remain poorly understood. This study utilized scanning electron microscopy (SEM), plant tissue sections, and silver nitrate staining techniques to comprehensively analyze the morphology of cystoliths in mulberry. Additionally, the distribution pattern of cystoliths was investigated, and mulberry seedlings were treated with 6-Benzylaminopurine (6-BA) and Abscisic acid (ABA). The results revealed that 6-BA significantly enhanced cystolith accumulation, whereas ABA had suppressive effects on cystolith formation in mulberry leaves. Furthermore, the concentration of applied phytohormones positively correlated with the yield of cystoliths. Based on these results, it is postulated that these phytohormones may modulate carbon absorption in mulberry by influencing stomatal conductance, thereby regulating cystolith formation. This research offers valuable insights into the underlying mechanisms driving mulberry cystolith formation and contributes to the optimal utilization of mulberry resources.
The Effect of Polygonum hyrcanicum Extract on Nephropathy in Alloxan-Induced Diabetic Mice
Authors: Arabnozari Hesamoddin , Shaki Fatemeh , Najjari Abolfazl , Habibi Emran 
Published: February 2024

Abstract

Diabetic nephropathy, characterized by inflammation and oxidative stress, poses a management challenge. This study investigates the effect of Polygonum hyrcanicum extract on diabetic nephropathy in alloxan-induced diabetic mice. The P.hyrcanicum extract was prepared using multiple macerations. Thirty male Albino mice, divided into five groups, were induced with alloxan-induced diabetes. They received intraperitoneal injections of the plant extract (100 and 200 mg/kg) and metformin (300 mg/kg) for four weeks. Kidney and blood samples were collected to assess protein carbonyl, glutathione, lipid peroxidation, TNF- and IL-6 levels. The amount of total flavonoid and phenolic content in the hydroalcoholic extract of P.hyrcanicum were 7.5±0.3 mg of quercetin and 88.2±1.3 mg gallic acid per gram of extract respectively. The antioxidant activity level of the hydroalcoholic extract was determined to be 1.78 ± 0.51 mM equivalent per gram of extract. Alloxan administration resulted in a significant reduction in glutathione levels and a significant increase in protein carbonyl, lipid peroxidation, TNF- , and IL-6 levels. P.hyrcanicum extract demonstrated potential in reducing oxidative stress and inflammation associated with diabetic nephropathy. However, no significant difference was observed between the two injection doses (100 and 200 mg/kg body weight) in reducing toxicities.
Plasmodium Falciparum neonatal malaria with atypical presentation: A case series from southwestern Ethiopia
Authors: Tesso Zerubabel Girma , Gossaye Tariku Yigremachew , Bekena Dereje Sileshi , Kebede Molla Asnake , Besir Fikretsion Degemu , Dabe Nikodimos Eshetu 
Published: February 2024

Abstract
Introduction:
Neonatal malaria detection of asexual stages of plasmodium species within the first 28 days of life. It can be congenital or acquired through mosquito bites or blood transfusions. Neonatal malaria is generally considered to be rare due to the multiple innate and acquired physiological protective effects present in neonates. However, in areas where malaria is endemic, the prevalence of malaria in neonates is high. The predominant clinical feature of malaria in neonates is fever. respiratory distress, pallor and anemia, hepatomegaly, refusal to feed, jaundice and diarrhea can be manifestations. Atypical presentations without fever can lead to inaccurate diagnosis and contribute to neonatal morbidity and mortality. Neonates from endemic areas with any of the above symptoms should be screened for malaria.
Case presentation:
We present a series of three cases of Neonatal plasmodium falciparum malaria Presented atypically without febrile episodes, who were diagnosed at Mizan-Tepi University Teaching Hospital between July and September 2023. The first patient presented with vomiting, refusal to feed, pallor, severe anemia, and splenomegaly. The second patient presented with an inconsolable cry, failure to pass feces, abdominal distention, and anemia. The third patient presented with vomiting and anemia. All patients received a 7-day course of intravenous artesunate; the first patient also received a blood transfusion. All patients recovered and were discharged.
Conclusions
Partial immunity resulting from repeated malaria infections in endemic regions may result in the transfer of high levels of maternal Immunoglobulin G (IgG) antibodies through the placenta, which bind to various plasmodial components and can produce different atypical clinical presentations. In malaria-endemic areas, neonates presenting with any of the presenting signs and symptoms of malaria, including afebrile presentation, require malaria screening to avoid delays in diagnosis.
Assessing cognitive function in cancer patients after chemotherapy
Authors: babaoglu elcin 
Published: February 2024

Abstract
Background: Chemotherapy-Related Cognitive Impairment (CRCI) is a problem that defines a widely defining cognitive functionality following the administration of chemotherapy treatment in cancerous patients in the present day. Previous studies reported that CRCI may continue for months receiving chemotherapy.
Objective: This study was conducted to assess the cognitive function in cancer patients after chemotherapy.
Methods: The present study was conducted in the oncology department of a state hospital in Turkey in descriptive design. The study population consisted of 100 patients who completed curative chemotherapy because of cancer and came to follow-ups in the 6th month. The “Montreal Cognitive Assessment Scale (MoCA)” was used in the study. In the analysis of the MOCA scale with independent variables, the One-Way Anova Test was used for more than two groups, and the Independent Samples T test was used for binary groups.
Results: The average of the general scores were found to be 18.73 ±3.7, and the cognitive function of 70% of the patients was low. The patients scored below the average scores that could be obtained in the language (1.31±0.971) and delayed recall (0.9±1.168) sub-dimensions. Those who took platinum and Taxane-containing cures had lower abstract thinking score averages than those who took only Taxane-containing cures.
Conclusion: Risky groups that might be affected in terms of cognitive functionality in cancer patients were female gender, being married, having low educational status, not working in an active job, and receiving platinum and Taxane-containing chemotherapy.
Effectiveness of an e-learning activity regarding research methodology and fragility fractures in a sample of nurses: Evidence from Greece
Authors: Galanis Petros , Katsiroumpa Aglaia , Moisoglou Ioannis , Nikiforou Areti , Kothonas Konstantinos , Athanasopoulou Katerina , Gallos Parisis , Panagiotopoulos Elias 
Published: February 2024

Abstract
Background: Continuous education is crucial to improve nurses’ knowledge and keep them update to new information.
Aim: To evaluate the effectiveness of an e-learning activity regarding research methodology and fragility fractures in a sample of nurses. Moreover, we investigated the impact of demographic characteristics on knowledge level of nurses.
Methods: We conducted a before-after study with a convenience sample of nurses working in different clinical settings. We conducted an e-learning activity regarding research methodology and fragility fractures. We developed 10 questions to assess the knowledge level of nurses before and after the e-learning activity. We created an online form of the questionnaire with Google forms. Our nurses completed the study questionnaire before and after the e-learning activity to assess differences in their knowledge. Additionally we measured overall evaluation, material evaluation, and educators’ evaluation in a scale from 0 to 10 with higher values indicating higher levels of evaluation.
Results: Study population included 93 nurses. Among our sample, 86% (n=80) were females and 14% (n=13) were males. Mean age of nurses was 37.1 years, while mean years of experience was 13.6. Percentage of correct answers was improved after the e-learning activity for all questions. Moreover, we found a statistically significant improvement in eight questions (p<0.05) and a marginal statistically significant improvement in two questions (p<0.10). Mean knowledge score before the e-learning activity was 5.5, while after the e-learning activity improved to 7.6 (p<0.001).
Conclusions: Effectiveness of the e-learning activity was very high, since nurses improved their knowledge in all fields. Continuous education is essential for nurses to improve their knowledge and thus provide high quality of healthcare especially in fragility fracture patients.
Decreased CO2 saturation during circular breathwork supports emergence of altered states of consciousness
Authors: Havenith Martha , Leidenberger Max , Brasanac Jelena , Corvacho Mafalda , Figueiredo Ines Carmo , Schwarz Leonie , Uthaug Malin , Rakusa Simona , Bernardic Marijan , Vasquez-Mock Liliana , Perez-Rosal Sergio , Carhart-Harris Robin , Gold Stefan , Jungaberle Henrik , Jungaberle Andrea 
Published: February 2024

Abstract
Altered states of consciousness (ASCs), induced e.g. by psychedelics, show great potential to treat widespread mental health disorders like depression and PTSD. However, access to such treatments is restricted by legal, medical, and financial barriers. Here, we explore the potential of circular breathwork to serve as an accessible, non-pharmacological alternative to engage similar therapeutic processes. Scientific studies investigating the mental health effects of breathwork are only just emerging and the underlying physiological and psychological mechanisms are largely unknown. In this study, we address these questions by tracking physiological and experiential dynamics throughout a breathwork session, comparing two popular forms of breathwork: Holotropic Breathwork® and Consciously-Connected breathwork. We show that a reduction in end-tidal CO2 pressure due to deliberate hyperventilation is instrumental in catalyzing ASCs during breathwork. ASCs evoked by breathwork were comparable to those produced by psychedelics, and their depth predicted psychological and physiological follow-on effects, including improved well-being and a reduction of depressive symptoms. Moreover, different breathwork formats produced highly similar physiological, experiential and psychological outcomes. These results outline physiological boundary conditions for ASCs to arise in a non-pharmacological context, shedding light on the functional mechanisms of breathwork as well as its potential as a psychotherapeutic tool.
Modeling an enterprise information and telecommunication system using colored Petri nets
Authors: Кочкин Д.В. , Горбунов В.А. 
Published: February 2024

Авторами разрабатываются модели объектов информационной системы предприятия: канал данных, сервер приложений и СУБД, комплексная модель для анализа. Разработанные модели могут быть использованы при проектировании и модернизации сетевой инфраструктуры предприятия, для оценки временных характеристик передачи трафика и оценки задержек для различных типов приложений. Модель сервера допускает гибкую настройку за счет задания различных типов задержек при обработке запросов. Адекватность моделей подтверждается результатами моделирования реального фрагмента компьютерной сети. Модели разработаны в среде CPN Tools.
The authors develop models of enterprise information system objects: data channel, application server and DBMS, complex model for analysis. The developed models can be used in design and modernization of the enterprise network infrastructure, to estimate the temporal characteristics of traffic transmission and to estimate delays for different types of applications. The server model allows for flexible configuration by setting various types of delays in processing of requests. The efficacy of the models is confirmed by the results of modeling a real fragment of the computer network. Models are developed in the CPN Tools environment.
Bibliografía sobre: La mente más allá de la representación: las múltiples caras de la cognición corporizada y las teorías de las 4E
Authors: Espinosa Barrios Adrián , Robles Zamora Alfredo 
Published: February 2024

Bibliografía sobre: La mente más allá de la representación: las múltiples caras de la cognición corporizada y las teorías de las 4E
Las fuentes bibliográficas que se presentan a continuación han sido seleccionadas de acuerdo con los siguientes criterios: a) Fuentes seminales, aquellas que, si bien no pertenecen propiamente al corpus de las ciencias cognitivas contemporáneas, son obras que contienen y han generado ideas claves para criticar al cognitivismo. b) Los textos clásicos, aquellas referencias obligadas en cuanto a las distintas perspectivas de la cognición (corporizadas, enactivas, extendidas o situadas). c) Los debates contemporáneos, las fuentes que presentan argumentos críticos en sus análisis para distinguir diferencias, afinar precisiones conceptuales y adecuaciones empíricas a las corrientes actuales.
DRUG RELATED PROBLEMS PADA TERAPI PENDERITA GAGAL JANTUNG KONGESTIF PERIODE JULI DESEMBER 2020 DI RSUP H. ADAM MALIK MEDAN
Authors: Tarigan Missiary Harmat 
Published: February 2024

Gagal Jantung Kongestif (GJK) adalah suatu kondisi dimana jantung mengalami kegagalan dalam memompa darah guna mencukupi kebutuhan sel-sel tubuh akan nutrisi dan oksigen secara adekuat. Terapi farmakologi yang dilakukan pada Pengobatan terapi penderita GJK dapat memungkinkan terjadinya Drug Related Problems (DRPs). Identifikasi DRPs menggunakan Klasifikasi Strand meliputi beberapa kriteria yaitu indikasi tanpa obat, obat tanpa indikasi, obat salah, dosis obat kurang, dosis obat berlebih, reaksi obat merugikan, dan interaksi obat. Penelitian ini bertujuan untuk mengetahui angka kejadian DRPs pada terapi pasien rawat Inap penderita gagal jantung kongestif di RSUP H. Adam Malik Medan. Penelitian ini menggunakan metode Retrospektif dengan pengambilan data pasien rawat inap GJK di RSUP H. Adam Malik Medan mulai dari Juli-Desember 2020 pada data rekam medis pasien. Data tersebut di analisis menggunakan IBM SPSS Statistics. Hasil identifikasi DRPs pada penatalaksanaan terapi pasien dengan Diagnosis Utama GJK tanpa komplikasi dan komorbiditas di instalasi rawat Inap RSUP H. Adam Malik Medan menunjukkan bahwa dari 10 pasien, terdapat 9 pasien (90 %) mengalami DRPs dan 1 pasien (10%) yang tidak mengalami DRPs. Terdiri dari indikasi tanpa obat 2 kasus (11,8 %), interaksi obat 15 kasus (88,2 %), sementara obat tanpa indikasi, obat tidak tepat,dosis obat kurang, dosis obat lebih, dan reaksi obat yang merugikan tidak ditemukan (0%). Dapat disimpulkan bahwa adanya kejadian DRPs pada terapi pasien Gagal Jantung Kongestif di Rumah Sakit Umum Pusat H. Adam Malik Medan periode Juli – Desember 2020.
Kata kunci: Gagal Jantung Kongestif, Drug Related Problems, RSUP H. Adam Malik Medan