bluuebunny/crossref_metadata_2025_split huggingface dataset:
The rise of multi-stakeholderism, the power of ultra-processed food corporations, and the implications for global food governance: a network analysis
Authors: Slater Scott , Lawrence Mark , Wood Benjamin , Serodio Paulo , Akker Amber Van Den , Baker Phillip 
Published: November 2023

Abstract

In recent decades, multi-stakeholder institutions (MIs) involving the ultra-processed food (UPF) industry have presented themselves as "part of the solution" to addressing malnutrition and other food systems sustainability challenges. This has raised concerns for many health and global food governance (GFG) scholars; however, few studies have investigated the governance composition and characteristics of these MIs, nor considered the implications for responses to UPFs and other major food systems challenges. We aimed to address this gap by conducting a network analysis, drawing quantitative and qualitative data from web sources, company reports, business and market research databases, and relevant academic and grey literature. In total, 45 global food systems MIs were identified. When combined, UPF industry executives and their business associates held almost half (n=263, or 43.8%) of the total 601 MI leadership positions, with Unilever (n=20), Nestlé (n=17), PepsiCo Inc (n=14), and The Coca-Cola Company (n=13) the most central to the network. Categorisation by various characteristics showed that corporations (n=431, or 71.7%), high-income countries (n=495, or 82.4%), and four countries (United States, Switzerland, United Kingdom, and the Netherlands) (n=350, or 58.2%) in particular, are dominant amongst the leadership of the MIs analysed. This study provides empirical evidence that many MIs, both hide the UPF industry’s harmful effects, and continue the perpetuation of long-standing food system inequalities and injustices. MIs involving the UPF industry are now a major structural feature of the GFG system, and regulatory changes are needed, to ensure a public health and sustainability first approach in GFG is prioritized.
INTERNALISASI PERAN PEMUDA DALAM MENGAKSELERASI LITERASI DAN PENGEMBANGAN PARIWISATA HALAL DENGAN KONSEP FIREFLIES ARISING SCENARIO (FAS)
Authors: Hariadi Muh Ikhsan 
Published: November 2023

Abstrak: Tulisan ini mengkaji bagaimana perananan pemuda sebagai aset bangsa dalam mengakselerasi proses literasi dan pengembangan pariwisata halal di Indonesia. Outlook pengembangan pariwisata halal di Indonesia yang dirilis oleh GMTI 2023 cukup menjanjikan di masa depan serta mampu meningkatkan perekonomian secara keseluruhan. Oleh karena itu diperlukan langkah-langkah strategis dari semua pihak untuk mengawal potensi tersebut supaya bisa tercapai dengan maksimal. Dalam kesempatan ini penulis menawarkan konsep Fireflies Arising Scenario (FAS). FAS menceritakan bagaimana mentransformasikan bangsa dengan gerakan-gerakan kecil, tak perlu slogan bombastis disana-sini. Konsep FAS akan terinternalisasi dengan peran pemuda serta terkoneksi dengan seluruh pemangku peran yang ada yaitu pemerintah, stakeholder, masyarakat dan lembaga keuangan. Masing-masing menjalankan fungsinya dan saling bersinergi melalui gerakan kecil secara massif dan konsisten. Konsep yang ditawarkan ini harapanya akan mampu membawa percepatan dalam pengembangan pariwisata halal di Indonesia. Sehingga geliat perkomonian melalui sektor pariwisata akan semakin kuat dan sektor pariwisata halal di Indonesia akan semakin dikenal dan membudaya oleh masyarakat dan seluruh dunia
Kata Kunci : Peran Pemuda; Pariwisata Halal; Fireflies Arising Scenario (FAS)

Abstract: This paper examines the role of youth as a national asset in accelerating the process of literacy and development of halal tourism in Indonesia. The outlook for the development of halal tourism in Indonesia released by GMTI 2023 is quite promising in the future and is able to improve the economy as a whole. Therefore, strategic steps are needed from all parties to guard this potential so that it can be optimally achieved. On this occasion the author offers the concept of Fireflies Arising Scenario (FAS). FAS tells how to transform a nation with small movements, no need for bombastic slogans here and there. The FAS concept will be internalized with the role of youth and connected with all existing stakeholders, namely government, stakeholders, communities and financial institutions. Each of them carries out its function and synergizes with each other through massive and consistent small movements. The concept offered is hoped to be able to bring acceleration in the development of halal tourism in Indonesia. So that the stretching of the communion through the tourism sector will get stronger and the halal tourism sector in Indonesia will become increasingly recognized and entrenched by the public and throughout the world.
Keywords : The Role of Youth; Halal Tourism; Fireflies Arising Scenario (FAS)
Effect of field of view of canopy temperature observations on crop water stress index for irrigation scheduling
Authors: Yadav Aditi , Upreti Hitesh , Singhal Gopal Das 
Published: November 2023

Abstract

The monitoring of canopy temperature (Tc) helps to establish appropriate watering methods. This study calculates the crop water stress index (CWSI) for four irrigation regimes in semi-arid region, India. Plots 1, 2, 3, and 4 had soil moisture depletion of 50% (drip system), 25% (drip system), unregulated (farmer replicated flood system), and 50% (flood system) with irrigation. In this work, we examined the value of employing a portable infrared thermometer (IRT) to measure wheat canopy temperature (Tc) at two geographical locations. The IRT field of view is 51.28–5,128 cm2, or 10–100 cm from the canopy crown. The field of view change from 10 to 100 cm affects Tc and CWSI in the four irrigation treatments, ranging from 0.65 to 2.71% and 9.2 to 36.4%, respectively. The research found that increasing the IRT from 10 to 100 cm reduced slope by 5.7% and intercept by 20.6% in lower baselines. The R2 for CWSI and soil moisture was 0.78 (10 cm) and 0.77 (100 cm). Drip-irrigated plots are more sensitive to IRT spatial resolution than flood-irrigated plots. The findings suggest that CWSI studies may benefit from specific sample methods for Tc evaluation.
EMANCIPAÇÃO
Authors: Mora Casasola Maria Fernanda 
Published: November 2023

A pesquisa objetivou problematizar o percurso histórico-filosófico do conceito emancipação desde o século XVII até o século XX, a partir dos seguintes autores selecionados: Immanuel Kant, Theodor Adorno, Max Horkheimer e alguns representantes dos movimentos de emergência e inmersão de projetos educativos e pedagógicos de Latinoamerica: Paulo Freire, Dermeval Saviani, Enrique Dussel e Marco Raúl Jiménez. Destacam-se algumas implicações desse conceito nas diferentes mudanças dos modelos sociais presentes nestas épocas. Trata-se de uma pesquisa bibliográfica, de natureza qualitativa. Ao abordar o conceito de emancipação, com ideias tais como: a emergência da consciência e a autonomia, surge o princípio de que a educação pode ser um meio para que o homem se torne homem. Portanto esse estudo indica a importância da consolidação de um projeto de educação democrática e inclusiva, que faça rupturas com paradigmas conservadores ancorados no ideário neoliberal que, na última década, tem se espraiado, especialmente no campo das políticas educacionais.
Unlocking the Benefits of Fasting: A Review of its Impact on Various Biological Systems and Human Health
Authors: Mackieh Rawan , Al-Bakkar Nadia , Kfoury Milena , Okdeh Nathalie , Pietra Hervé , Roufayel Rabih , Legros Christian , Fajloun Ziad , Sabatier Jean-Marc 
Published: November 2023

Abstract:Fasting has gained significant attention in recent years for its potential health benefits in various body systems. This review aims to comprehensively examine the effects of fasting on human health, specifically focusing on its impact on different body’s physiological systems. The cardiovascular system plays a vital role in maintaining overall health, and fasting has shown promising effects in improving cardiovascular health markers such as blood pressure, cholesterol levels, and triglyceride levels. Additionally, fasting has been suggested to enhance insulin sensitivity, promote weight loss, and improve metabolic health, thus offering potential benefits to individuals with diabetes and metabolic disorders. Furthermore, fasting can boost immune function, reduce inflammation, enhance autophagy, and support the body's defense against infections, cancer, and autoimmune diseases. Fasting has also demonstrated a positive effect on the brain and nervous system. It has been associated with neuroprotective properties, improving cognitive function, and reducing the risk of neurodegenerative diseases, besides the ability of increasing the lifespan. Hence, understanding the potential advantages of fasting can provide valuable insights for individuals and healthcare professionals alike in promoting health and wellbeing. The data presented here may have significant implications for the development of therapeutic approaches and interventions using fasting as a potential preventive and therapeutic strategy.
Synthetic and Biological Studies of Some Pyrrolidine-Tethered Novel Aurones against
Digestive Enzymes
Authors: Kumar Sanjeev , Saroha Bhavna , Lathwal Ekta , Kumar Gourav , Arya Priyanka , Raghav Neera , Kumar Ramesh , Kumar Suresh 
Published: November 2023

Abstract:
Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or
inhibition is of potent therapeutic approach for treating various body disorders. In this
work, we have synthesized a small library of pyrrolidine-tethered novel aurones 4(a-k) and
structures validated by analyzing their IR, NMR (1H and 13C), and mass spectrometry data.
The biological activities of the synthesized aurones were evaluated through in vitro and in
silico experiments against digestive enzymes. A distinct pattern emerged, with significant
activation observed for trypsin and amylase, while lipase was notably inhibited. Among the
synthesized compounds, 4f produced the highest lipase inhibition (72.3%), whereas 4k
showed maximum activation for trypsin (EC50 = 0.94×10-6 M) and 4f activated amylase
(EC50 = 8.76×10-4 M) to the maximum extent, thus confirming their possible use as agents
for combating inflammation and obesity.
Hsa_circ_0001278 Facilitates Colorectal Cancer Progression via Sponging miR-338-5p and Regulating AMOTL1 Expression
Authors: Ge Hua , Yan Yan , Wang Haomin , Bian Jun , Deng Zhilong , Su Xian , Yang Zaicai , Song Jiacheng 
Published: November 2023

Background:
Colorectal cancer (CRC) ranks as the third most common cancer and is
second in terms of mortality worldwide. Circular RNAs are involved in the occurrence and development
of malignant tumors by functioning either as oncogenes or tumor suppressors.

Method:
This study investigated the functions of hsa_circ_0001278 in CRC. We analyzed the
expression of hsa_circ_0001278 in CRC tissues and adjacent normal tissues. In order to understand
the roles of hsa_circ_0001278 in CRC in terms of cellular biological behavior, in vitro experiments
were conducted. A mechanistic study was designed to investigate the regulatory effect
of hsa_circ_0001278 on CRC.

Results:
Hsa_circ_0001278 was found to be significantly upregulated in CRC specimens. The
functional analysis indicated that hsa_circ_0001278 promotes aggressive phenotypes of CRC
cells. Further mechanistic studies revealed that hsa_circ_0001278 sponges miR-338-5p to regulate
angiomotin-like 1 (AMOTL1), thereby facilitating CRC progression.

Conclusion:
Our results demonstrate that hsa_circ_0001278 promotes malignant behaviors in
CRC cells by sponging miR-338-5p to regulate AMOTL1 expression. This suggests that
hsa_circ_0001278 may serve as a novel target for CRC treatment.
Splicing DNA Damage Adaptations for the Management of Cancer Cells
Authors: Singh Arun Kumar , Yadav Deepika , Malviya Rishabha 
Published: November 2023

Abstract:
Maintaining a tumour cell's resistance to apoptosis (organized cell death) is essential
for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic
process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage,
but its ultimate goal is always the same: the removal of damaged cells that might otherwise
develop into tumours. Many chemotherapy drugs rely on cancer cells being able to undergo apoptosis
as a means of killing them. The mechanisms by which DNA-damaging agents trigger apoptosis,
the interplay between pro- and apoptosis-inducing signals, and the potential for alteration of these
pathways in cancer are the primary topics of this review.
The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria
Authors: Omosigho Pius Omoruyi , John Okesanya Olalekan , Adigun Olaniyi Abideen , Hassan Hakeem Kayode , Olabode Olaleke Noah , Micheal Abioye Sunday , Haruna Usman Abubakar , Singh Amandeep , Manirambona Emery 
Published: November 2023

Abstract:
Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including
in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly
contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not
treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immunization regimens. The outbreak is further aggravated by multiple epidemics, which have diverted resources and attention away from the emergency of other infectious
diseases. Furthermore, there is a lack of awareness of diphtheria in Nigeria. With a focus on the difficulties in controlling the disease, methods of diagnosis, available treatments, and preventive
measures, this study provides a thorough analysis of diphtheria, covering its historical context, clinical presentation, associated complications, and current outbreaks. It emphasizes how important vaccination, early detection, and better access to healthcare are in reducing diphtheria outbreaks. The
study highlights the serious effects of diphtheria on public health, particularly in regions with scarce
resources and vaccine resistance, and offers a number of suggestions to overcome these challenges
and prevent further outbreaks.
Unlocking the Potential: A Comprehensive Review for the Synthesis of Benzofuran Derivatives
Authors: Patel Krina , Patel Heli , Shah Drashti , Patel Dharti , Savaliya Neel , Bambharoliya Tushar , Shah Ashish , Mahavar Anjali , Patel Ashish 
Published: November 2023

Abstract:Benzofuran, a versatile heterocyclic compound, has gained considerable attention in recent years due to its diverse biological activities, distinctive structural characteristics, broad synthetic approaches, and extensive applications. The growing potential inherent in benzofuran encourages many researchers to address the challenges of the synthesis of its framework. This comprehensive review aims to provide a detailed overview of the recent advancements in the synthesis of diverse benzofuran derivatives, highlighting innovative strategies, synthetic methodologies, and significant breakthroughs in the field. The synthetic methodologies are classified as metalcatalyzed routes, green-solvent-based routes, microwave-assisted methods, catalyst-free and solvent- free methods, and a miscellaneous group of routes. This categorization in review provides an easy means for the reader to rationally select the best possible synthetic method for benzofuran derivatives. In addition, it explores the use of different solvents and catalysts in benzofuran synthesis, which serves as a valuable resource for chemists, researchers, and scientists involved in pharmaceutical and allied sciences. Overall, this review provides a comprehensive overview of the synthesis of benzofuran scaffolds and complies with all the significant developments in the synthetic routes of benzofuran, which will be useful for researchers interested in the development of new benzofuran-based molecules.
A Case Report of Different Management Protocols for Uncomplicated Crown Fracture in Young Permanent Teeth; Fragment Reattachment vs. Resin Restoration
Authors: Alkhuwaiter Shahad S. , Alssafi Fatimah 
Published: November 2023

Introduction:
An uncomplicated crown fracture (enamel-dentin fracture) is the most clinically reported traumatic injury. Many techniques have been reviewed to manage this traumatic injury. The literature has no consensus on the best strategy to establish optimal biological, functional, and esthetical success.

Objective:
This clinical case reports different management of uncomplicated crown fractures in young permanent teeth that were successfully treated using both tooth fragment reattachment and composite build-up.

Case Report:
A 9-year-old female presented as an emergency patient with immature fractured upper central incisors. She hit her mouth into a solid wall and broke her front teeth during playing. Upon parental advice, the fragments were stored in a container of milk since the incident. For dental management, two treatment approaches were used.

Conclusion:
After a two-year follow-up, the treatment is considered successful and the traumatized teeth are vital, functional and presented with a complete root development.
Salivary Biomarkers and their Relationship with Periodontal Clinical Parameters: A Cross-Sectional Study
Authors: Marin Rubiel , Duque Andres , Cardona Doris , Giraldo Erika , Salazar Lina 
Published: November 2023

Background:
Traditionally, periodontal clinical parameters are used to diagnose and design standardized treatment plans. The scientific literature has not widely reported the inclusion of salivary biomarkers in this diagnostic and therapeutic process.

Objectives:
To analyze the correlation between salivary biomarkers and periodontal clinical parameters of a group of patients undergoing the periodontal maintenance phase in a private dental office located in the southwest of Colombia.

Material and Methods:
A cross-sectional study was carried out. A sample of 92 patients undergoing the periodontal maintenance phase was analyzed. Conventional periodontal parameters were determined, and salivary biomarkers were measured by chromatography (cariogenic bacteria, acidity, buffering capacity, blood, and erythrocytes). To determine its correlation, a bivariate statistical analysis was developed.

Results:
According to Spearman's correlation matrix, among the periodontal clinical parameters, there were statistically significant correlations between the extension and severity of the complete and proximal attachment loss (r=0.93) and between the bleeding on probing (BOP) and the plaque index (PI) (r= 0.37). Within the salivary biomarkers, a statistically significant correlation was found between acidity and the buffering capacity of saliva (r= -0.54); between buffering capacity and proteins (r=0.36); between blood and erythrocytes (r=0.42); between blood and proteins (r=0.58), and between erythrocytes and proteins (r=0.48). Finally, a statistically significant correlation between periodontal parameters and salivary biomarkers was observed between teeth lost due to periodontal disease and acidity (r=0.26) and between teeth lost and buffer capacity (r=0.30).

Conclusion:
Periodontal parameters and salivary biomarkers correlate with variables of the same group to which they belong. Still, only the variable teeth lost due to periodontal disease correlates with acidity and buffer capacity. The findings suggest that both periodontal parameters and salivary biomarkers should be evaluated throughout the periodontal process. It is possible that both parameters could express different moments of the pathophysiology of the disease.
Ten Years of Experience With a Telemedicine Platform Dedicated to Health Care Personnel: Implementation Report
Authors: Azzolini Claudio , Premi Elias , Donati Simone , Falco Andrea , Torreggiani Aldo , Sicurello Francesco , Baj Andreina , Azzi Lorenzo , Orro Alessandro , Porta Giovanni , Azzolini Giovanna , Sorrentino Marco , Melillo Paolo , Testa Francesco , Simonelli Francesca , Giardina Gianfranco , Paolucci Umberto 
Published: November 2023

Background
Telemedicine, a term that encompasses several applications and tasks, generally involves the remote management and treatment of patients by physicians. It is known as transversal telemedicine when practiced among health care professionals (HCPs).

Objective
We describe the experience of implementing our telemedicine Eumeda platform for HCPs over the last 10 years.

Methods
A web-based informatics platform was developed that had continuously updated hypertext created using advanced technology and the following features: security, data insertion, dedicated software for image analysis, and the ability to export data for statistical surveys. Customizable files called “modules” were designed and built for different fields of medicine, mainly in the ophthalmology subspecialty. Each module was used by HCPs with different authorization profiles.

Implementation (Results)
Twelve representative modules for different projects are presented in this manuscript. These modules evolved over time, with varying degrees of interconnectivity, including the participation of a number of centers in 19 cities across Italy. The number of HCP operators involved in each single module ranged from 6 to 114 (average 21.8, SD 28.5). Data related to 2574 participants were inserted across all the modules. The average percentage of completed text/image fields in the 12 modules was 65.7%. All modules were evaluated in terms of access, acceptability, and medical efficacy. In their final evaluation, the participants judged the modules to be useful and efficient for clinical use.

Conclusions
Our results demonstrate the usefulness of the telemedicine platform for HCPs in terms of improved knowledge in medicine, patient care, scientific research, teaching, and the choice of therapies. It would be useful to start similar projects across various health care fields, considering that in the near future medicine as we know it will completely change.