bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting the Photo‐Physical Properties of Metal Halide Perovskite Nanocrystals for Bioimaging
Authors: Zhang Jiahui , Zhu Yifan 
Published: November 2023

AbstractPerovskite nanomaterials have recently been exploited for bioimaging applications due to their unique photo‐physical properties, including high absorbance, good photostability, narrow emissions, and nonlinear optical properties. These attributes outperform conventional fluorescent materials such as organic dyes and metal chalcogenide quantum dots and endow them with the potential to reshape a wide array of bioimaging modalities. Yet, their full potential necessitates a deep grasp of their structure‐attribute relationship and strategies for enhancing water stability through surface engineering for meeting the stringent and unique requirements of each individual imaging modality. This review delves into this evolving frontier, highlighting how their distinctive photo‐physical properties can be leveraged and optimized for various bioimaging modalities, including visible light imaging, near‐infrared imaging, and super‐resolution imaging.
Phosphonium‐substituted Diphosphaindenylide (PPI): Exploration of Biradical Character and Ligand Properties
Authors: Coburger Peter , Zuber David , Schweinzer Clara , Scharnhölz Moritz 
Published: November 2023

AbstractStarting from C6H4(PCl2)2 and the TMS‐substituted ylide (TMS)2C=PR3 (TMS=trimethylsilyl, R=p‐tolyl), the phosphonium‐substituted diphosphaindenylide PPI was prepared in two steps. CASSCF calculations as well as the reactivity toward diphenyl acetylene suggest a notable biradical character in PPI. Reaction with [Cr(CO)3(MeCN)3] affords the complex [Cr(CO)3(η5‐PPI)] (5). This complex was employed to explore the ligand properties of PPI, which demonstrates considerable potential through the combination of strong metal‐ligand interactions and the possibility of a pronounced indenyl effect.
A Green Environmental Protection Photocatalytic Molecular Reactor for Aerobic Oxidation of Sulfide to Sulfoxide
Authors: Chen Jia‐Qi , Zhang Kai‐Yang , Zhang Xiu‐Du , Huang Zi‐Qing , Deng Hong , Zhao Yue , Shi Zhuang‐Zhi , Sun Wei‐Yin 
Published: November 2023

AbstractThe design and synthesis of metal‐organic frameworks (MOFs) as photocatalytic molecular reactors for varied reactions have drawn great attention. In this work, we designed a novel photoactive perylenediimides‐based (PDI) carboxylate ligand N,N’‐di(3’,3”,5’,5”‐tetrakis(4‐carboxyphenyl))‐1,2,6,7‐tetrachloroperylene‐3,4,9,10‐tetracarboxylic acid diimide (Cl‐PDI‐TA) and use it to successfully synthesize a novel Zr(IV)‐based MOF 1 constructed from [Zr6O8(H2O)8]8+ clusters bridged by Cl‐PDI‐TA ligands. Structural analysis revealed that Zr‐MOF 1 manifests a 3D framework with (4,8)‐connected csq topology and possesses triangular channels of ~17 Å and mesoporous hexagonal channels of ~26 Å along c‐axis. Moreover, the synthesized Zr‐MOF 1 exhibits visible‐light absorption and efficient photoinduced free radical generation property, making it a promising photocatalytic molecular reactor. When Zr‐MOF 1 was used as a photocatalyst for the aerobic oxidation of sulfides under irradiation of visible light, it could afford the corresponding sulfoxides with high yield and selectivity. Experimental results demonstrated that the substrate sulfides could be fixed in the pores of 1 and directly transformed to the products sulfoxides in the solid state. Furthermore, the mechanism for the photocatalytic transformation was also investigated and the results revealed that the singlet oxygen (1O2) and superoxide radical (O2⋅−) generated by the energy transfer and electron transfer from the photoexcited Zr‐MOF to oxidants were the main active species for the catalytic reactions. This work offers a perceptive comprehension of the mechanism in PDI‐based MOFs for further study on photocatalytic reactions.
American Registry of Ambulatory or acutely decompensated heart failure (AMERICCAASS Registry): First 1000 patients
Authors: Gómez‐Mesa Juan Esteban , Gutiérrez‐Posso Juliana María , Escalante‐Forero Manuela , Córdoba‐Melo Brayan Daniel , Cárdenas‐Marín Paula Andrea , Perna Eduardo R. , Valle‐Ramos Mádelyn Raquel , Giraldo‐González Germán Camilo , Flórez‐Alarcón Noel Alberto , Rodríguez‐Caballero Ida Fabiola , Núñez‐Carrizo Cristian , Cabral‐Gueyraud Luz Teresa , Marte‐Arias Sarah Raquel , Hardin Elizabeth Ashley , Álvarez‐Sangabriel Amada , Menjívar‐De Ramos María Eugenia , van der Hilst Kwame , Cruz‐Díaz Licurgo Jacob , Fausto Ovando Sergio Roberto , Rodríguez Luis Arturo , Escalante Juan Pablo , Ormaechea‐Gorricho Gabriela , Bornancini Norberto Raul , Rodríguez‐González María Juliana , Campbell‐Quintero Sebastián , González‐Hormostay Raquel E. , Oviedo‐Pereira Guillermo , Trout‐Guardiola Guillermo , Encina Juan Justiniano , Jerez‐Castro Ana Margarita , Drazner Mark , Quesada‐Chaves Daniel , Romero‐Guerra Alexander , Rossel‐Mariángel Víctor Alejandro , Speranza Mario 
Published: November 2023

AbstractBackgroundAbout 80% of cardiovascular diseases (including heart failure [HF]) occur in low‐income and developing countries. However, most clinical trials are conducted in developed countries.HypothesisThe American Registry of Ambulatory or Acutely Decompensated Heart Failure (AMERICCAASS) aims to describe the sociodemographic characteristics of HF, comorbidities, clinical presentation, and pharmacological management of patients with ambulatory or acutely decompensated HF in America.MethodologyDescriptive, observational, prospective, and multicenter registry, which includes patients >18 years with HF in an outpatient or hospital setting. Collected information is stored in the REDCap electronic platform. Quantitative variables are defined according to the normality of the variable using the Shapiro–Wilk test.ResultsThis analysis includes data from the first 1000 patients recruited. 63.5% were men, the median age of 66 years (interquartile range 56.7–75.4), and 77.6% of the patients were older than 55 years old. The percentage of use of the four pharmacological pillars at the time of recruitment was 70.7% for beta‐blockers (BB), 77.4% for angiotensin‐converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB II)/angiotensin receptor‐neprilysin inhibitor (ARNI), 56.8% for mineralocorticoid receptor antagonists (MRA), and 30.7% for sodium–glucose cotransporter type‐2 inhibitors (SGLT2i). The main cause of decompensation in hospitalized patients was HF progression (64.4%), and the predominant hemodynamic profile was wet‐warm (68.3%).ConclusionsAMERICCAASS is the first continental registry to include hospitalized or outpatient patients with HF. Regarding optimal medical therapy, approximately a quarter of the patients still need to receive BB and ACEI/ARB/ARNI, less than half do not receive MRA, and more than two‐thirds do not receive SGLT2i.
Accessing Functionalized Tetrazines as Click Chemistry Tools: A Synthesis Guide for Chemists and Chemical Biologists
Authors: Bickem Lucas Moritz , Gavriel Katerina , Neumann Kevin 
Published: November 2023

AbstractSince the first report that 1,2,4,5‐tetrazines undergo a bioorthogonal reaction with dienophiles in the form of an inverse electron‐demand Diels‐Alder reaction, the demand for high‐yielding synthetic approaches towards them grew steadily. Despite this significant interest, tetrazines were predominantly accessed via the Pinner synthesis or other Pinner‐like reactions, significantly limiting available substrates. In particular, the synthesis of unsymmetrically substituted s‐tetrazines for the selective conjugation to another species presented a major challenge. To tackle these challenges, new and innovative high‐yielding transformations have been developed to widen the scope of accessible symmetric and unsymmetric tetrazines. For instance, Ni(II), Zn(II), and sulphur‐catalysed reactions between two nitriles and hydrazine were developed, which provide access to a wide range of (un‐)symmetric aryl s‐tetrazines. Also, amidines and orthoesters give tetrazines with alkyl substituents, whereas the usage of CH2Cl2 yields valuable H‐monosubstituted tetrazines. Methods using thiocarbohydrazides, terminal fluoroolefins, oxetane esters, or tosyl hydrazones are among the recent additions. Due to the high interest in tetrazine click‐chemistry approaches, some of which reach beyond inverse electron‐demand Diels‐Alder reactions, we expect this overview of synthetic routes to aid the exploration for further applications of tetrazines. Ultimately, we hope to provide a guide for chemists and chemical biologists for accessing functional s‐tetrazines.
PACS2 pathogenic variant associated with malformation of cortical development and epilepsy
Authors: Checri Rayann , Dozières‐Puyravel Blandine , Elmaleh‐Bergès Monique , Verloes Alain , Auvin Stéphane 
Published: November 2023

AbstractPACS2 pathogenic variants are associated with an autosomal dominant syndrome (OMIM DEE66), associating developmental and epileptic encephalopathy, facial dysmorphism, and cerebellar dysgenesis. However, no malformation of cortical development has been reported yet. We report here a seven‐year‐old child with a history of infantile epileptic spasm syndrome and a right insular polymicrogyria and pachygyria due to de novo PACS2 recurrent mutation c.625G>A (p.Glu209Lys). Our observation raises the question of the role of PACS2 in the cortical development. It also reminds the importance of cerebellar anomalies in the recognition of PACS‐related DEE.
Risk factors for sarcopenia in patients with head and neck cancer
Authors: Liu Chen , Cheng Ling , Ye Wenfeng , Lin Lizhu 
Published: November 2023

AbstractObjectiveSarcopenia is a common condition among patients with cancer. To better understand the prevalence of sarcopenia in patients with head and neck cancer (HNC), we analysed the risk factors of sarcopenia and developed a theoretical foundation for further development of sarcopenia prevention and treatment strategies.MethodsSix hundred and seventeen patients with HNC were recruited for this cross‐sectional observational study, and the data were analyzed using logistic regression analyses. The bioelectrical impedance analysis (BIA) was used to measure skeletal muscle mass, and sarcopenia was diagnosed according to the 2019 diagnostic criteria of the Asian Sarcopenia Working Group (AWGS).ResultsAmong the 617 patients enrolled in the study, 115 (18.6%) had sarcopenia. The prevalence of sarcopenia was 29.1% in males and 8% in females. In the multivariate analysis, older age (OR = 12.266, 95% CI: 3.864–38.934, p < 0.01), body fat (OR = 1.775, 95% CI: 1.511–2.084, p < 0.01), and sex (OR = 138.659, 95% CI: 42.382–453.642, p < 0.01) were independent risk factors for sarcopenia. Body mass index (BMI) (OR = 0.137, 95% CI: 0.09–0.21, p < 0.01), and total body water/fat free mass (TBW/FFM) (OR = 0.122, 95% CI: 0.031–0.474, p < 0.01) were protective factors for sarcopenia; we observed that sarcopenia decreased with increasing BMI and TBW/FFM.ConclusionsMale sex, advanced age, and excess body fat were identified as risk factors for sarcopenia in patients with HNC, whereas a higher BMI and TBW/FFM acted as protective factors against sarcopenia in these patients.
Reconstruction of the anterior maxillary defect using a vascularized bone flap with residual teeth in the posterior maxilla
Authors: Li Zi‐Meng , Kang Yi‐Fan , Zhang Lei , Yang Yi‐Fan , Shan Xiao‐Feng , Cai Zhi‐Gang 
Published: November 2023

AbstractBackgroundMicrosurgical bone reconstruction is challenging in cases of anterior maxillary defects because of the presence of residual teeth. The study analyzed the method and feasibility of using vascularized bone flaps to reconstruct anterior maxillary defects.MethodsWe retrospectively analyzed 15 patients treated at the Department of Oral and Maxillofacial Surgery, Peking University School, and Hospital of Stomatology between November 2017 and January 2023.ResultsA total of 14 patients were successfully reconstructed using the digital technique: 6 deep circumflex iliac artery (DCIA) flaps and 8 fibular free flaps. Palatal and buccal pedicle paths were used in 4 and 10 cases, respectively, for vascular anastomosis. The implant coverage rates of the DCIA and fibular free flaps were 87.2% and 92.6%, respectively (p > 0.05).ConclusionAnterior maxillary defects reconstructed with the DCIA and fibular free flaps are reliable methods. Furthermore, the palatal and buccal paths are recommended for vascular anastomosis.
Quasicrystalline Antimony Thin Films
Authors: Raj Sharma Hem , Nugent Peter John , Coates Sam , McGrath Ronan 
Published: November 2023

AbstractThe growth of antimony (Sb) thin films on the fivefold surface of icosahedral Ag−In−Yb quasicrystal has been studied by scanning tunneling microscopy (STM) and x‐ray photoelectron spectroscopy (XPS). At low coverage, the deposited Sb yields a network of pentagons of different sizes and heights. These Sb pentagons can be mapped by a pentagonal tiling of the substrate and thus exhibit quasicrystalline long‐range order. Subsequent deposition of Sb yields a disordered film. XPS observations of the growth mode are consistent with the STM results.
Koumine inhibits RANKL‐induced ubiquitination and NF‐κB activation to prevent ovariectomy and aging‐induced bone loss
Authors: You Jiongming , Xu Dingjun , Zhang Chenxi , Chen Yilin , Huang Song , Bian Huihui , Lv Juan , Chen Dagui , Su Li , Yin Heng , Li Yinghua , Wang Yong 
Published: November 2023

AbstractOsteoporosis (OP) is a bone remodeling disease characterized by an imbalance between bone resorption and formation. Osteoclasts are the primary therapeutic targets for treating bone destruction. Koumine (KM), the most bioactive component in Gelsemium alkaloids, exhibits antitumor, immunosuppressive, anti‐inflammatory, and analgesic properties. However, the effects of bone loss have not been well studied. This study conducted in vitro and in vivo verification experiments on KM. The results showed that KM inhibited bone resorption and tartrate‐resistant acid phosphatase positive (TRAP+) osteoclasts development by mature osteoclasts in a dose‐dependent manner. Moreover, KM prevented OVX‐induced OP in vivo and potentially inhibited ubiquitination, a process closely related to various biological activities, including protein interaction, transcription, and transmembrane signal transduction regulation, especially within the nuclear factor‐κB (NF‐κB) pathway. Previous studies have demonstrated that several proteins ubiquitination promotes osteoclastogenesis, our study indicated that KM inhibits early NF‐κB activation and receptor activator of NF‐κB ligand induced ubiquitination, a critical factor in osteoclast differentiation. In conclusion, our research suggests that KM holds potential as an effective therapeutic agent for OP.
Homologous chromosome pairing: The linchpin of accurate segregation in meiosis
Authors: Tian Yuqi , Liu Libo , Gao Jinmin , Wang Ruoxi 
Published: November 2023

AbstractMeiosis is a specialized cell division that occurs in sexually reproducing organisms, generating haploid gametes containing half the chromosome number through two rounds of cell division. Homologous chromosomes pair and prepare for their proper segregation in subsequent divisions. How homologous chromosomes recognize each other and achieve pairing is an important question. Early studies showed that in most organisms, homologous pairing relies on homologous recombination. However, pairing mechanisms differ across species. Evidence indicates that chromosomes are dynamic and move during early meiotic stages, facilitating pairing. Recent studies in various model organisms suggest conserved mechanisms and key regulators of homologous chromosome pairing. This review summarizes these findings and compare similarities and differences in homologous chromosome pairing mechanisms across species.
Evaluation of biological potential of UV‐spectrophotometric, SEM, FTIR, and EDS observed Punica granatum and Plectranthus rugosus extract‐coated silver nanoparticles: A comparative study
Authors: Akhtar Muhammad Faran , Irshad Muhammad , Ali Shaukat , Summer Muhammad , Gulrukh Saima , Irfan Muhammad 
Published: November 2023

AbstractRecent developments in the green synthesis of metallic nanoparticles (NPs) using phytoconstituents have attracted the attention of the global scientific community. The present study was designed to synthesize silver NPs (AgNPs) using Punica granatum and Plectranthus rugosus plant extracts. The fabricated AgNPs were characterized using UV–visible spectrophotometry (UV–Vis), Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and energy‐dispersive x‐ray spectroscopy (EDS). The shift in the color of the silver nitrate (AgNO3) solution after the addition of P. granatum and P. rugosus extracts indicated the synthesis of AgNPs. The effect of AgNO3 concentrations and pH on the synthesis of AgNPs was also evaluated. The findings of this study suggest that AgNO3 concentration of 1 mM, reaction time of 1 h, and pH of 7 at room temperature were the best suited conditions for the synthesis of AgNPs. According to the FTIR analysis, amidic and carbonyl compounds were primarily responsible for the encapsulation of AgNPs. SEM investigations have shown irregularly shaped geometry with sizes of 35 nm (P. granatum) and 33 nm (P. rugosus) with low agglomeration. The prepared AgNPs exhibited good potential for 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging, with values of 70% (P. granatum) and 68% (P. rugosus). Hence, we conclude that the leaves of P. granatum and P. rugosus are excellent material for designing of different plant‐extracted‐conjugated AgNPs for biomedical applications.Research Highlights
Preparation of the AgNPs using novel plants extracts.
P. granatum and P. rugosus extract as reducing, capping, stabilizing, and optimizing agents.
Thorough comparative characterization using UV–Vis spectrophotometer, FTIR, SEM, and EDS which is a first of its kind.
Comparative antioxidant activity.
Nanoinjection of extracellular vesicles to single live cells by robotic fluidic force microscopy
Authors: Kovács Kinga Dóra , Visnovitz Tamás , Gerecsei Tamás , Peter Beatrix , Kurunczi Sándor , Koncz Anna , Németh Krisztina , Lenzinger Dorina , Vukman Krisztina V. , Balogh Anna , Rajmon Imola , Lőrincz Péter , Székács Inna , Buzás Edit I. , Horvath Robert 
Published: November 2023

AbstractIn the past decade, extracellular vesicles (EVs) have attracted substantial interest in biomedicine. With progress in the field, we have an increasing understanding of cellular responses to EVs. In this Technical Report, we describe the direct nanoinjection of EVs into the cytoplasm of single cells of different cell lines. By using robotic fluidic force microscopy (robotic FluidFM), nanoinjection of GFP positive EVs and EV‐like particles into single live HeLa, H9c2, MDA‐MB‐231 and LCLC‐103H cells proved to be feasible. This injection platform offered the advantage of high cell selectivity and efficiency. The nanoinjected EVs were initially localized in concentrated spot‐like regions within the cytoplasm. Later, they were transported towards the periphery of the cells. Based on our proof‐of‐principle data, robotic FluidFM is suitable for targeting single living cells by EVs and may lead to information about intracellular EV cargo delivery at a single‐cell level.
Don't Let it be! Creative Co‐regulation and Socially Shared Regulation in a Case Study of the Beatles: Get Back
Authors: Urban Kamila , Urban Marek 
Published: November 2023

ABSTRACTCriticism has been raised about creativity researchers narrowing their focus solely to the cognitive processes within individuals. To address these concerns, this case study seeks to expand the scope of creativity research by delving into metacognitive, motivational, and emotional processes involved in collaborative creative problem‐solving. The present study applies the concepts of self‐regulation, co‐regulation, and socially shared regulation to a real‐world case study: the documentary The Beatles: Get Back. Observational footage of the band rehearsing and creating new songs for their live show is analyzed within a socially shared regulation of learning (SSRL) framework. Theory‐driven coding identified individual facets of self‐regulation, co‐regulation, and socially shared regulation during collaborative creative problem‐solving. The analysis revealed initial problems with self‐regulation, especially motivation and emotion regulation, inhibiting collaboration. However, co‐regulatory prompts between group members facilitated a shift toward more productive socially shared regulation where the band collectively negotiated goals, plans and ideas. An examination of spontaneous interactions highlighted the interplay between individual self‐regulation and socially constructed regulation shaping real‐world creative collaboration. Individual metacognitive skills, motivation, and emotions, as well as socially shared group dynamics enabled the members to regulate uncertainty and obstacles in collaborative creative problem‐solving.
Prince and princesses: The current status of robotic surgery in surgical oncology
Authors: Hays Sarah B. , Corvino Gaetano , Lorié Benjamin D. , McMichael William V. , Mehdi Syed A. , Rieser Caroline , Rojas Aram E. , Hogg Melissa E. 
Published: November 2023

AbstractRobotic surgery has experienced a dramatic increase in utilization across general surgery over the last two decades, including in surgical oncology. Although urologists and gynecologists were the first to show that this technology could be utilized in cancer surgery, the robot is now a powerful tool in the treatment of gastrointestinal, hepato–pancreatico–biliary, colorectal, endocrine, and soft tissue malignancies. While long‐term outcomes are still pending, short‐term outcomes have showed promise for this technologic advancement of cancer surgery.
Kinderlähmung: Schluckimpfung neu aufgelegt
Authors: Groß Michael 
Published: November 2023

AbstractGegen die Kinderlähmung gibt es zwei Arten von Impfstoffen. Beide haben Nachteile, welche die geplante Ausrottung der Krankheit verzögert haben. Ein neuer Impfstoff soll nun einen Ausweg bieten.
Nachruf: Michael Maiwald (1967 – 2023)
Authors: Eifert Tobias , Engelhard Carsten 
Published: November 2023

AbstractMichael Maiwald war ein herausragender Physiko‐ und analytischer Chemiker. Besonders den Arbeitskreis Prozessanalytik der GDCh‐Fachgruppe Analytische Chemie hat er stark geprägt.