bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering the Crystalline Packing Advantages of Asymmetric Y‐Series Acceptors for Efficient Additive‐Insensitive and Intrinsically Stable Organic Solar Cells
Authors: Xia Xinxin , Mei Le , Sun Rui , Li Shuixing , Chen Chun‐Yu , Lin Jhih‐Min , Min Jie , Chen Hongzheng , Chen Xian‐Kai , Lu Xinhui 
Published: February 2024

AbstractOrganic solar cells (OSCs) hold immense potential as renewable energy sources, but the performance‐stability conundrum remains a major obstacle on the road to OSC commercialization. To address this, in this study, molecular packing behaviors of representative state‐of‐the‐art Y‐series non‐fullerene acceptors (NFAs) are studied, focusing on their terminal group symmetries. Utilizing grazing‐incidence wide‐angle X‐ray scattering, the distinct crystalline packing structure of these NFAs is revealed. Remarkably, NFAs with asymmetric terminals exhibited excellent additive insensitivity and thermal stability for their crystalline structure, unlike their symmetric counterparts. Molecular dynamics simulations confirmed the stable and robust crystalline feature of asymmetric NFAs and attributed to their large molecular dipole moments. These findings showed the great potential of asymmetric NFAs in fabricating efficient and intrinsically stable additive‐free OSC devices for real applications.
Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model
Authors: Rossano Samantha M. , Johnson Aubrey S. , Smith Anna , Ziaggi Galen , Roetman Andrew , Guzman Diana , Okafor Amarachukwu , Klein Julia , Tomljanovic Zeljko , Stern Yaakov , Brickman Adam M. , Lee Seonjoo , Kreisl William C. , Lao Patrick 
Published: February 2024

AbstractINTRODUCTIONEvidence suggests microglial activation precedes regional tau and neurodegeneration in Alzheimer's disease (AD). We characterized microglia with translocator protein (TSPO) positron emission tomography (PET) within an AD progression model where global amyloid beta (Aβ) precedes local tau and neurodegeneration, resulting in cognitive impairment.METHODSFlorbetaben, PBR28, and MK‐6240 PET, T1 magnetic resonance imaging, and cognitive measures were performed in 19 cognitively unimpaired older adults and 22 patients with mild cognitive impairment or mild AD to examine associations among microglia activation, Aβ, tau, and cognition, adjusting for neurodegeneration. Mediation analyses evaluated the possible role of microglial activation along the AD progression model.RESULTSHigher PBR28 uptake was associated with higher Aβ, higher tau, and lower MMSE score, independent of neurodegeneration. PBR28 mediated associations between tau in early and middle Braak stages, between tau and neurodegeneration, and between neurodegeneration and cognition.DISCUSSIONMicroglia are associated with AD pathology and cognition and may mediate relationships between subsequent steps in AD progression.
Electrochemical Ni‐Catalyzed Decarboxylative C(sp3)−N Cross‐Electrophile Coupling
Authors: Cai Yue‐Ming , Liu Xiao‐Ting , Xu Lin‐Lin , Shang Ming 
Published: February 2024

AbstractA new electrochemical transformation is presented that enables chemists to couple simple alkyl carboxylic acid derivatives with an electrophilic amine reagent to construct C(sp3)−N bond. The success of this reaction hinges on the merging of cooperative electrochemical reduction with nickel catalysis. The chemistry exhibits a high degree of practicality, showcasing its wide applicability with 1°, 2°, 3° carboxylic acids and remarkable compatibility with diverse functional groups, even in the realm of late‐stage functionalization. Furthermore, extensive mechanistic studies have unveiled the engagement of alkyl radicals and iminyl radicals; and elucidated the multifaceted roles played by iPr2O, Ni catalyst, and electricity.
Manganese‐Catalyzed Mono‐N‐Methylation of Aliphatic Primary Amines without the Requirement of External High‐Hydrogen Pressure
Authors: Ji Jiale , Huo Yinghao , Dai Zhaowen , Chen Zhening , Tu Tao 
Published: February 2024

AbstractThe synthesis of mono‐N‐methylated aliphatic primary amines has traditionally been challenging, requiring noble metal catalysts and high‐pressure H2 for achieving satisfactory yields and selectivity. Herein, we developed an approach for the selective coupling of methanol and aliphatic primary amines, without high‐pressure hydrogen, using a manganese‐based catalyst. Remarkably, up to 98 % yields with broad substrate scope were achieved at low catalyst loadings. Notably, due to the weak base‐catalyzed alcoholysis of formamide intermediates, our novel protocol not only obviates the addition of high‐pressure H2 but also prevents side secondary N‐methylation, supported by control experiments and density functional theory calculations.
Enantioselective Construction of C−SCF3 Stereocenters via Nickel Catalyzed Asymmetric Negishi Coupling Reaction
Authors: Hu Duo‐Duo , Nie Tian‐Mei , Xiao Xi , Li Kuiliang , Li Yuan‐Bo , Gao Qian , Bi Yu‐Xiang , Wang Xi‐Sheng 
Published: February 2024

AbstractThe construction of the SCF3‐containing 1,1‐diaryl tertiary carbon stereocenters with high enantioselectivities is reported via a nickel‐catalyzed asymmetric C−C coupling strategy. This method demonstrates simple operations, mild conditions and excellent functional group tolerance, with newly designed SCF3‐containing synthon, which can be easily obtained from commercially available benzyl bromide and trifluoromethylthio anion in a two‐step manner. Further substrate exploration indicated that the reaction system could be extended to diverse perfluoroalkyl sulfide (SC2F5, SC3F7, SC4F9, SCF2CO2Et)‐substituted 1,1‐diaryl compounds with excellent enantioselectivities. The synthetic utility of this transformation was further demonstrated by convenient derivatization to optical SCF3‐containing analogues of bioactive compounds without an apparent decrease in enantioselectivity.
Post‐transfusion purpura after cardiac surgery associated with veno‐arterial extracorporeal membrane oxygenation*
Authors: Lovisari F. , Gonzenbach T. , Hemmaway C. , Sadani D. , Hogan M. 
Published: February 2024

SummaryWe report the case of a woman who developed post‐transfusion purpura following complicated cardiac surgery requiring multiple blood product transfusions and extracorporeal life support. This case highlights the challenges of managing thrombocytopenia in patients supported with prolonged mechanical cardiovascular and renal support with ongoing blood product transfusion requirements. The differential diagnoses are broad, varied and may overlap. Whilst post‐transfusion purpura is very rare, clinical signs may prompt consideration and further specific diagnostic testing. Once confirmed, management is then specific, with some aspects which are at direct variance with standard intensive care and extracorporeal life support guidelines for the management of non‐specific thrombocytopenia. Consideration of the diagnosis of post‐transfusion purpura early in the clinical course could help anticipate and prevent a vicious cycle of bleeding, transfusion and autoimmune‐mediated platelet disruption, and may improve clinical outcomes.
Natural gas dehydration membranes prepared by incorporating environmentally friendly metal‐organic framework MIP‐202 into polyetherimide
Authors: Zhang Xiaocan , Zeng Siqin , Long Jiashu , Li Xuesong , Zhao Yutong 
Published: February 2024

AbstractUsing porous materials to selectively adsorb H2O from natural gas is a promising method to dehydrate methane (CH4). The structure of a Zirconium metal‐organic framework (Zr‐MOF), namely, MIP‐202, features a high density of amino groups, which can produce strong hydrogen bonding with H2O molecules. MIP‐202 is cost‐effective, green and scalable, and it exhibits good chemical stability under various conditions. This work incorporated MIP‐202 nanoparticles into the high permeability polymer polyetherimide (PEI), and the obtained Mixed Matrix Membranes (MMMs) was used for the gas separation of H2O/CH4. It is found that MMMs loaded with 20 wt% of MIP‐202 demonstrated a high H2O/CH4 selectivity of 832.2, which was about 760 times of that of the pure PEI. This approach offers a new route to fabricate functional membranes for energy‐efficient gas separations.
Polyurethane hard domain composed of mixed hard segments
Authors: Wang Zhihong , Li Lixia , Yang Kai , Wang Dongqi , Zhao Xin , Cheng Sisi , Fu Meishan , Han Lijing , Zhang Ruoyu 
Published: February 2024

AbstractThe packing of hard segment in polyurethane hard domain has not been resolved or seen clearly yet. In this work, we prepared polyurethane blends, which were composed of different weight ratios of crystallizable 1195A and non‐crystallizable EG85A, to study the structural evolution and crystallization in mixed hard domain. Time and temperature dependent differential scanning calorimetry, Fourier transform infrared spectroscopy (FTIR), and x‐ray diffraction results were used to record the micro‐phase evolution and crystallization processes. It was very surprising to find that the multiple melting temperatures in these blends were similar. We deduced that the packing of hard segment tended to separate into different groups, probably dependent on their segmental length. The crystalline nucleus was consist of 1195A hard segments with similar length, and the out‐layer structure was consisted of mixed hard segments of varying lengths. The FTIR results demonstrated that crystallinity did not affect the degree of hydrogen bonding association (HBA), and the stacking of hard segments may be only differed in the degree of ordering. Moreover, the degree of HBA of the blends was always higher than the calculated number based on weight ratio of pure samples.
Effect of raster angle on the fracture properties of additively manufactured ABS via essential work of fracture
Authors: Rajaee Pouya , Ashenai Ghasemi Faramarz , Sajjadi Seyyed Ali , Fasihi Mohammad 
Published: February 2024

AbstractThe increasing application of additive manufacturing (AM) technology across various sectors has sparked significant interest in characterizing 3D‐printed components. An essential aspect of achieving fracture‐resistant designs is gaining a comprehensive understanding of the fracture behavior exhibited by these components. While most studies have focused on linear‐elastic fracture mechanics (LEFM), there is a lack of comprehensive studies on the post‐yield fracture behavior (PYFM) of 3D‐printed components. As a result, this study aims to fill this gap by investigating the impact of raster angle, a critical parameter influencing fracture properties and often leading to premature failures, on the fracture properties of fused deposition modeling (FDM) 3D printed acrylonitrile butadiene styrene (ABS) using essential work of fracture (EWF). Outcomes showed that by changing lay‐ups from [90]5 to [0]5, the value of we or elastic work increased by nearly 306%. Further, the maximum and minimum values of the plastic work (βwp) were for [45/−45/45/−45/45] and [90]5 lay‐ups, in order. By changing lay‐ups from [90]5 to [45/−45/45/−45/45], the value of βwp increased by approximately 216%. In addition, the fractured surfaces of tested samples are also analyzed to provide insights into the dominant failure mechanisms for different raster angles.
The tympanoperiotic complex of the blue whale, Balaenoptera musculus
Authors: Bisconti Michelangelo , Bosselaers Mark , Locatelli Camille , Carnevale Giorgio , Lambert Olivier 
Published: February 2024

AbstractThe tympanoperiotic complex of a blue whale Balaenoptera musculus is described and compared to the homologous structures in the other extant and fossil baleen whale species. The periotic and the tympanic bulla represent informative anatomical regions in both functional and phylogenetic studies and for this reason a micro‐CT scan of the bones was performed in order to better characterize their external aspect and to reconstruct the inner structures. In particular, the cochlea, the semicircular canals and associated portions of the periotic are reconstructed so that these structures may be used in phylogenetic analyses. We observed that the blue whale periotic is characterized by the presence of a strong dorsal protrusion which is posteriorly bordered by a previously undescribed morphological character that we name the posterotransverse fossa. The peculiar shape of the anterior process and the en echelon organization of the posterior foramina of the pars cochlearis are also described and compared. From a phylogenetic perspective, the blue whale is confirmed to be closely related to the fin whale, Balaenoptera physalus, but it is suggested, based on ear bone characters only, that it diverged before the other balaenopterid species in the phylogeny of Balaenopteridae. This placement supports a series of morphological observations suggesting that the extant blue whale was an early‐diverging member of Balaenoptera. Our results help to decipher the evolutionary origin of the blue whale, the largest living animal, by allowing new and more detailed morphological analyses of the balaenopterid fossil record.
Novel iterative cubature Kalman filters under maximum correntropy criterion for the robust state estimation
Authors: Lu Tao , Zhou Weidong , Hu Yue , Tong Shun 
Published: February 2024

AbstractThe cubature Kalman filter (CKF) based on maximum correntropy criterion (MCC) is robust under non‐Gaussian noises, but it may encounter numerical problems when there are large outliers. First, based on the MCC and weighted least square (WLS) methods, a new cost function is introduced to calculate the state and covariance updates, which can better solve numerical problems caused by large outliers. Then, a nonlinear measurement function is used, and the measurement information is updated through the latest iterative values, which can obtain more accurate results under various non‐Gaussian noises. In addition, the Gauss–Newton, Levenberg–Marquardt, and Quasi–Newton methods are used, and three iterative algorithms named GN‐IMCC‐CKF, LM‐IMCC‐CKF, and QN‐IMCC‐CKF are respectively derived for the updating steps. Compared with the existing algorithms, the simulation results of two classical models show that the proposed algorithms have better numerical stability and estimation accuracy under non‐Gaussian systems.
Investigation of a transient increase in omphalocele prevalence in a birth cohort of TRICARE beneficiaries
Authors: Lanning Jackielyn , Magallon Sandra Michelle , Bukowinski Anna T. , Gumbs Gia R. , Conlin Ava Marie S. , Hall Clinton 
Published: February 2024

AbstractBackgroundThe Department of Defense Birth and Infant Health Research (BIHR) program leverages medical encounter data to conduct birth defect surveillance among infants born to military families. Omphalocele is a major abdominal wall defect with an annual prevalence of ~2 per 10,000 births in BIHR data, but an unexpected increase was observed during 2017–2019, reaching 6.4 per 10,000 births in 2018. To investigate this transient increase in prevalence, this study aimed to validate the omphalocele case algorithm among infants born 2016–2021.MethodsOmphalocele cases were identified by ICD‐10 code Q79.2 (exomphalos) on one inpatient or two outpatient infant encounter records and validated using parental and infant electronic health records. Characteristics of true and false positive cases were assessed using bivariate analyses and compared over time.ResultsOf 638,905 live births from 2016 to 2021, 230 met the ICD‐10 case definition for omphalocele; 138 (60.0%) cases were eligible for validation, of which 68 (49.3%) were true positives. The geometric mean time from birth to first ICD‐10 omphalocele diagnosis was 1.1 (standard error [SE] 0.1) days for true positives and 11.9 (SE 3.1) days for false positives. Among the 70 false positives, 36 (51.4%) were cases of confirmed umbilical hernia; rates of umbilical hernia and delayed omphalocele diagnoses (>30 days after birth) were elevated among false positives during 2017–2019.ConclusionsHigher misuse of ICD‐10 code Q79.2 during 2017–2019 likely influenced the associated increase in omphalocele prevalence. Timing of diagnosis should be considered for omphalocele case definitions using medical encounter data.
A colorimetric detection of dopamine in urine and serum based on the CeO2@ZIF‐8/Cu‐CDs laccase‐like nanozyme activity
Authors: Yin Qinhong , Wang Yutong , Yang Dezhi , Yang Yaling , Zhu Yanqin 
Published: February 2024

AbstractThis study reports a sensitive and selective colorimetric approach for the analysis of dopamine (DA) based on CeO2@ZIF‐8/Cu‐CDs laccase‐like nanozymes activity. The CeO2@ZIF‐8/Cu‐CDs was synthesized using cerium oxide (CeO2) and copper‐doped carbon dots (Cu‐CDs) with 2‐methylimidazole by a facilely hydrothermal approach. The CeO2@ZIF‐8/Cu‐CDs exhibited excellent laccase‐like nanozymes activity and can oxidize the colorless substrate (DA) to red product with 4‐aminoantipyrine as the chromogenic agent. The Michaelis–Menten constant (Km) and the maximal velocity (Vmax) of CeO2@ZIF‐8/Cu‐CDs are 0.20 mM and 1.48 μM/min, respectively. The detection method has a linear range of 0.05–7.5 μg/mL and a detection limit as low as 8.5 ng/mL with good reproducibility. The developed colorimetric sensor was applied to rapid and precise quantitative evaluation of DA levels in serum and urine samples. This study presents a new approach for detecting biological molecules by utilizing the controlled regulation of nanozymes' laccase‐like activity.
Clinical characteristics of persistent postural‐perceptual dizziness and its visual subtype in Korean patients: A multicenter cross‐sectional study
Authors: Park Joo Hyun , Nguyen Thanh Tin , Kim Sung‐Hee , Park Ji‐Yun , Na Seunghee , Jeon Eun‐Ju , Seo Ji won , Cho Chang Gun , Oh Se‐Joon , Choi Sung‐Won , Choi Kwang‐Dong , Choi Seo‐Young , Choi Ji Eun , Hong Sung‐Kwang , Chung Won‐Ho , Cho Young Sang , Lee Hwan Ho , An Yong‐Hwi , Han Kyu‐Hee , Lee Hyung , Kim Hyun Ah , Lee Ho Yun , Lee Jong‐Dae , Lee Se A , Oh Sun‐Young 
Published: February 2024

AbstractObjectivesPersistent postural‐perceptual dizziness (PPPD) is a chronic functional vestibular disorder for which the Bárány Society has established diagnostic criteria. This nationwide multicenter study aims to investigate the clinical features of individuals with definite PPPD and clinical variant PPPD who do not fully meet the diagnostic criteria, with a particular focus on visual exaggeration.MethodsBetween September 2020 and September 2021, a total of 76 individuals with definite PPPD and 109 individuals with clinical variant PPPD who did not meet all three exacerbating factors outlined in Criterion B were recruited from 18 medical centers in South Korea. The study gathered information on demographic factors, clinical manifestations, balance scales, and personality assessments.ResultsComparative analysis between groups with definite PPPD and clinical variant with visual exacerbation revealed no significant differences in sociodemographic characteristics, clinical course, dizziness impact, and specific precipitants. Only disease duration was significantly longer in definite PPPD compared with variant with visual exacerbation. However, the variant without visual exacerbation displayed significantly reduced rates of panic disorder, diminished space‐motion discomfort, lesser impact of dizziness, and decreased prevalence of depression when compared with the definitive PPPD.ConclusionThis is the first comprehensive nationwide study examining clinical features of both definite PPPD patients and its clinical variants, considering visual exacerbating factors. Differences in dizziness and personality traits emerged between definite PPPD and its potential variant without visual issues. Our results highlight the possibility of a distinct clinical variant of PPPD influenced by visual dependency.
Carbon ion irradiation exerts antitumor activity by inducing cGAS–STING activation and immune response in prostate cancer‐bearing mice
Authors: Hu Wei , Zhang Zhenshan , Xue Yushan , Ning Renli , Guo Xiaomao , Sun Yun , Zhang Qing 
Published: February 2024

AbstractBackground and PurposeAs an advanced radiotherapy technique, carbon ion radiotherapy has demonstrated good efficacy and low toxicity for prostate cancer patients, but the radiobiological mechanism of killing tumor cells has not been fully elucidated. This study aims to explore the antitumor effects of carbon ion irradiation (CIR) through investigating the immune response induced by CIR in prostate cancer‐bearing mice and the underlying molecular mechanism.Materials and MethodsWe established subcutaneous transplantation tumor models of prostate cancer to evaluate the tumor inhibition effect of CIR. Investigation of immunophenotype alterations were assessed by flow cytometry. Immunofluorescence, western blot, and real‐time quantitative PCR was employed to analyze the activation of cGAS–STING pathway.ResultsCIR showed more powerful tumor growth control than photon irradiation in immunocompetent syngeneic C57BL/6 mice. CIR exerts antitumor effect by triggering immune response, characterized by increased CD4+ T cells and macrophages in tumor, enhanced CD8+ T cells and T effector memory cells in spleen, improved IFN‐γ production of CD8+ tumor‐infiltrating lymphocytes, and reduced exhausted T cells in tumor and spleen. Additionally, production of cytoplasmic double‐stranded DNA, protein levels of p‐TBK1 and p‐IRF3 in the cGAS–STING pathway, and gene expression levels of downstream interferon‐stimulated genes were significantly increased after CIR in a dose‐dependent manner. Treatment of RM1 tumor‐bearing mice with the STING inhibitor C‐176 impaired the antitumor effect of CIR.ConclusionThe excellent antitumor activity of CIR in immunocompetent prostate cancer‐bearing C57BL/6 mice may be attributed to stronger induction of antitumor immune response and higher activation of cGAS–STING pathway.
α‐Umpolung/Michael Addition/Quaternization Tandem Reaction to provide α‐Imido‐β‐phosphonium Propanoates with Broad Spectrum of Biological Activity
Authors: Il'in Anton V. , Anisimova Kristina S. , Bogdanov Andrei V. , Shulaeva Marina P. , Pozdeev Oskar K. , Babaeva Olga B. , Voloshina Alexandra D. , Serov Nikita Yu. , Bukharov Mikhail S. , Islamov Daut R. 
Published: February 2024

AbstractThis paper has been supported by the Kazan Federal University Strategic Academic Leadership Program (‚PRIORITY‐2030‘). HRMS data were obtained in the CSF‐SAC FRC KSC RAS by support of the State Assignment of the Federal Research Center “Kazan Scientific Center”, Russian Academy of Sciences. A.D.V, conducted studies of anticancer activity with financial support form the government assignment for FRC Kazan Scientific Center of RAS.
A stepwise approach to coronary artery stenting in acute type A aortic dissection
Authors: Singh Kuljit , Niranjan Selva , Hibbert Benjamin , Taramasso Maurizio 
Published: February 2024

AbstractWe present three cases of acute coronary obstruction postsurgical repair of type A aortic dissection, which were successfully treated with percutaneous coronary intervention. We describe a step‐by‐step approach to performing percutaneous coronary intervention in selective cases of coronary obstruction related to type A aortic dissection.