bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maxillary and Mandibular Displacement in Hemifacial Microsomia: A Longitudinal Roentgen Stereometric Study of 21 Patients with the Aid of Metallic Implants
Authors: Sarnäs Karl-Victor , Rune Bodil , Åberg Magnus 
Published: May 2004

Objective To record maxillary and mandibular displacement with articular growth and in response to bimaxillary surgical repositioning in patients with hemifacial microsomia (HFM) and to observe ipsilateral corpus/ramus growth in severely affected children. Design Prospective roentgen stereometric analysis (mean age 7 years 10 months to 18 years 0 months) and retrospective profile and panoramic roentgenograms. Mean total observation period was 9 years 1 month. Setting Department of Plastic and Reconstructive Surgery, Malmö University Hospital (Malmö, Sweden). Patients Twenty-one patients consecutively diagnosed from 1976 through 1988 with HMF, five of whom had bimaxillary surgery. Interventions Surgery was performed at the Department of Plastic and Reconstructive Surgery. Implants were inserted at the initial reconstructive surgical procedure under general anesthesia. Roentgen examinations were performed in connection with continued clinical evaluations and treatment. Main Outcome Measures Stereo roentgenograms were digitized at the Department of Orthopedic Surgery, Malmö University Hospital (Malmö, Sweden). Results Displacement of the jaws with articular growth and in response to bimaxillary surgical repositioning varied interindividually with no apparent common pattern. Relapse displacement occurred several years after bimaxillary surgery. Mandibular growth changes were found in the corpus/ramus area and alveolar process on the affected side. Conclusions A marked interindividual variability of maxillary and mandibular displacement indicates that the relevance of statistical analysis of HFM growth data may be questioned. We would suggest that precise and accurate longitudinal recordings of growth and response to surgery in individual HFM patients be more appropriate.
A Rare Craniofacial Cleft: Numbers 7, 2, and 3 Clefts Accompanied by a Single Median Lip Pit
Authors: Sigler Michael Orlin , Stein John , Zuker Ronald 
Published: May 2004

Objective A unique case of a unilateral partial Tessier no. 7 cleft accompanied by no. 2 and 3 clefts along with a single median lip pit is presented. The history, genetics, epidemiology, classifications, embryology, pathogenesis, and correction techniques are briefly reviewed. After an extensive review of the literature, we conclude that this particular constellation of anomalies has not previously been described.
A Modified Muscle-Activated Maxillary Orthopedic Appliance for Presurgical Nasoalveolar Molding in Infants with Unilateral Cleft Lip and Palate
Authors: Suri Sunjay , Tompson Bryan D. 
Published: May 2004

Objective The purpose of this article is to describe a modified appliance and treatment approach for presurgical nasoalveolar molding in infants with unilateral cleft lip and palate. Methods This approach uses a plate held in with outriggers, which prevents the cleft-widening effect of the tongue, helps with tongue tip placement, and utilizes the functional movements of the facial musculature to guide and relocate the major segment medially to its normal position. Nasal molding is undertaken after most of the lateromedial correction of the alveolar position. Conclusions This technique helps to improve alveolar position, nasal septum alignment, nasal symmetry, and nasal tip projection prior to lip repair.
Oral Rehabilitation of an Orthodontic Patient with Cleft Lip and Palate and Hypodontia Using Secondary Bone Grafting, Osseo-Integrated Implants, and Prosthetic Treatment
Authors: Kawakami Shingo , Yokozeki Masahiko , Horiuchi Shinya , Moriyama Keiji 
Published: May 2004

Objective Complete skeletal and dental reconstruction of the anterior maxilla is of great importance to patients with cleft lip and palate. Accordingly, osseo-integrated implants have been utilized for dental reconstruction after secondary bone grafting. In this report, the orthodontic management of a patient with unilateral cleft lip and plate with associated hypodontia is described. The patient was treated with comprehensive orthodontic treatment in addition to secondary bone grafting, and dental reconstruction was achieved with a combination of osseo-integrated implants and fixed prosthodontic treatment.
Variations in Facial Soft Tissues of Italian Individuals with Ectodermal Dysplasia
Authors: Sforza Chiarella , Dellavia Claudia , Vizzotto Laura , Ferrario Virgilio F. 
Published: May 2004

Objective To supply quantitative information about the facial soft tissues of patients with ectodermal dysplasia (ED). Design, Setting, and Patients The three-dimensional coordinates of soft tissue facial landmarks were obtained using an electromagnetic digitizer in 20 Caucasian patients with ED (11 male and 9 female patients aged 7 to 41 years) and 391 healthy controls (163 female and 228 male subjects of comparable ages). From the landmarks, 15 facial dimensions and two angles were calculated. Data were compared with those collected in healthy individuals by computing z-scores. Two summary anthropometric measurements for quantifying craniofacial variations were assessed in both the patients and reference subjects: the mean z-score (an index of overall facial size) and its standard deviation, called the craniofacial variability index (an index of facial harmony). Results In patients with ED, a large variability was found for both the mean z-score and the craniofacial variability index. On average, the patients had a somewhat smaller facial size than the normal individuals, with a global disharmonious appearance. Overall, 70% of patients fell outside the quantitative definitions for normal facial size, harmony or both. When examining the distribution of the single z-scores of the 17 selected measurements, variable patterns were found, without consistent effects of age or sex. Conclusions The facial soft tissue structures of patients with ED differed both in size and shape from those of normal controls of the same age, sex, and ethnic group.
Global Strategies to Reduce the Health Care Burden of Craniofacial Anomalies: Report of WHO Meetings on International Collaborative Research on Craniofacial Anomalies
Authors: Shaw William 
Published: May 2004

Although several significant research projects have arisen from international cooperation, especially in the field of genetics, these have been the exception rather than the rule. However, those of us who had the privilege and delight of participating in the World Health Organization meetings were struck by a common realization of the vast potential of systematic international cooperation. It is clear that the global model will be the most effective approach for tackling the big questions in craniofacial anomalies, be they concerned with cause, treatment, or prevention. This report will serve as a road map for making collaboration the rule and not the exception and hopefully be a stimulus for the creation of partnerships between international research teams and funding agencies.
Dendrimere in Lösung – Erkenntnisse aus Theorie und Simulation
Authors: Ballauff Matthias , Likos Christos N. 
Published: May 2004

AbstractEine Vielzahl von theoretischen Untersuchungen und Experimenten zeigt, dass gelöste Dendrimere sich wie flexible Polymere in guten Lösungsmitteln verhalten und daher am besten als Makromoleküle mit einem dichten Kern und fluktuierenden Monomerbausteinen beschrieben werden. Wir zeigen hier mithilfe von analytischer Theorie und Simulationen, wie sich Form und innere Struktur mit zunehmender Generationszahl ändern und welche effektiven Wechselwirkung zwischen gelösten Dendrimeren bestehen. Ein Ansatz auf der Basis einer vergröberten dendritischen Struktur sagt einstellbare weiche Wechselwirkungen zwischen den Schwerpunkten gelöster Dendrimere voraus. Die Ergebnisse von Kleinwinkelstreuexperimenten bestätigen die Theorie. Demnach sind Dendrimere ultraweiche Modellkolloide, deren Eigenschaften zwischen denjenigen von Polymeren und harten Kugeln liegen. Dendrimere können also mit verwandten Systemen wie Sternpolymeren und Blockcopolymer‐Micellen verglichen werden, sie weisen aber auch spezielle Eigenschaften auf.
PrRuSi2 and Nd(RuxNi1‐x)Si2, Monoclinic Variants of the CeNiSi2 Structure.
Authors: Salamakha P. S. , Rizzoli C. , Sologub O. L. , Belletti D. , Protsyk O. S. , Goncalves A. P. , Almeida M. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enhanced Blue and Green Upconversion in Hydrothermally Synthesized Hexagonal NaY1‐xYbxF4:Ln3+ (Ln3+: Er3+ or Tm3+).
Authors: Liang Lifang , Wu Hao , Hu Haili , Wu Mingmei , Su Qiang 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sandwich‐Type Germanotungstates: Structure and Magnetic Properties of the Dimeric Polyoxoanions [M4(H2O)2 (GeW9O34)2]12‐ (M: Mn2+, Cu2+, Zn2+, Cd2+).
Authors: Kortz Ulrich , Nellutla Saritha , Stowe Ashley C. , Dalal Naresh S. , Rauwald Urs , Danquah Welbeck , Ravot Didier 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
3‐(2‐Pyrrolidin‐1‐ylethyl)‐5‐(1,2,3,6‐tetrahydropyridin‐4‐yl)‐1H‐indole Derivatives as High Affinity Human 5‐HT1B/1D Ligands.
Authors: Egle Ian , MacLean Neil , Demchyshyn Lidia , Edwards Louise , Slassi Abdelmalik , Tehim Ashok 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Access to the 1H‐Pyrazolo[4,3‐c]pyridine Core from Bis‐acetylenic‐N‐benzoylhydrazones.
Authors: Commeiras Laurent , Woodcock Samuel C. , Baldwin Jack E. , Adlington Robert M. , Cowley Andrew R. , Wilkinson Peter J. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Biologically Active Compounds Through Catalysis: Efficient Synthesis of N‐(Heteroarylcarbonyl)‐N′‐(arylalkyl)piperazines.
Authors: Kumar Kamal , Michalik Dirk , Garcia Castro Ivette , Tillack Annegret , Zapf Alexander , Arlt Michael , Heinrich Timo , Boettcher Henning , Beller Matthias 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Highly Efficient Synthesis of Lamellarins K (Ia) and L (Ib) by the Michael Addition/Ring‐Closure Reaction of Benzyldihydroisoquinoline Derivatives with Ethoxycarbonyl‐β‐nitrostyrenes.
Authors: Ploypradith Poonsakdi , Mahidol Chulabhorn , Sahakitpichan Poolsak , Wongbundit Siriporn , Ruchirawat Somsak 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Expression of concern: Overexpression of synuclein‐γ in pancreatic adenocarcinoma
Authors: Li Zhongkui , Sclabas Guido M. , Peng Bailu , Hess Kenneth R. , Abbruzzese James L. , Evans Douglas B. , Chiao Paul J. 
Published: May 2004

AbstractBACKGROUNDCurrently, pancreatic adenocarcinoma is the fourth leading cause of cancer‐related death in the United States. Despite the advances in pancreatic carcinoma research, patients with this devastating disease have a very poor prognosis. To identify the gene expression profile of pancreatic carcinoma, an important step in the process of developing new diagnostic and therapeutic strategies, the authors investigated the alteration of gene expression in this disease.METHODSThe authors analyzed a public serial analysis of gene expression (SAGE) database and examined in greater detail the expression of synuclein‐γ mRNA in several pancreatic carcinoma cell lines and tumor tissue samples by reverse transcriptase–polymerase chain reaction (RT‐PCR) analysis and Northern blot analysis. The expression of synuclein‐γ protein was investigated further by immunohistochemical and Western blot analyses using tumor cell lines, tumor tissue, and serum samples.RESULTSSynuclein‐γ mRNA was overexpressed in 11 of 12 pancreatic carcinoma cell lines, including AsPc‐1, MDAPanc28, Capan‐1, Capan‐2, PANC‐1, HS766T, MDAPanc3, MDAPanc48, Colo357FG, MiaPaCa2, CFPac1, and BxPc3. The expression of synuclein‐γ protein was detectable in 8 of 12 pancreatic carcinoma cell lines (67%) and in 22 of 32 pancreatic tumor tissue samples (69%) by Western blot analysis. On immunohistochemical staining, synuclein‐γ protein was present in 61% of the tumor tissue samples examined from patients with Stage I and II pancreatic carcinoma. The overexpression of synuclein‐γ is correlated with perineural and lymph node invasion. Synuclein‐γ protein also was detectable by Western blot in serum samples from 21 of 56 patients (38%) with pancreatic carcinoma.CONCLUSIONSSynuclein‐γ, which initially was described as a breast carcinoma–specific gene involved in invasion, metastasis, and chemotherapy resistance, was frequently overexpressed in pancreatic carcinoma. Overexpression of synuclein‐γ may play a role in pancreatic carcinoma invasion. Further studies will be necessary to determine the role of synuclein‐γ in pancreatic carcinoma. Cancer 2004. © 2004 American Cancer Society.
Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder
Authors: Cheng Liang , MacLennan Gregory T. , Zhang Shaobo , Wang Mingsheng , Pan Chong‐Xian , Koch Michael O. 
Published: May 2004

AbstractBACKGROUNDIn the 1999 World Health Organization classification system, papillary tumors of the urinary bladder were classified as papilloma, papillary urothelial neoplasm of low malignant potential (PUNLMP), and as Grade 1, Grade 2, and Grade 3 urothelial carcinoma. The biologic potential of PUNLMP of the urinary bladder is controversial. To the authors' knowledge, information regarding the genetic changes of PUNLMP tumors of the bladder is limited.METHODSThe authors examined loss of heterogygosity (LOH) at 5 polymorphic microsatellite markers on chromosome 9q32–33 (D9S177), 9p22 (IFNA), 17p13.1 (TP53), 12q14–24 (D12S1051), and 3p25–26 (D3S3050) from 26 patients who were diagnosed with PUNLMP tumors of the urinary bladder. Tumors were microdissected from sections prepared from formalin‐fixed, paraffin‐processed tissue specimens using laser capture microdissection.RESULTSLOH was found in 21 of 26 (81%) patients with PUNLMP. The rate of LOH was 41% with D9S177, 32% with IFNA, 29% with TP53, 26% with D12S1051, and 44% with D3S3050. Allelic loss of multiple chromosome loci was often present in patients with PUNLMP tumors.CONCLUSIONSGenetic changes that commonly occur in advanced bladder carcinoma (≥ pT2) are frequently found in PUNLMP of the urinary bladder. Cancer 2004. © 2004 American Cancer Society.
Design of circularly polarized dielectric resonator antennas using modal polarization current model method
Authors: Inoue Takashi , Inagaki Naoki , Kikuma Nobuyoshi , Sakakibara Kunio 
Published: May 2004

AbstractIn the circularly polarized dielectric resonator antenna (CP‐DRA), the one‐point feed method with a simplified configuration of the feed system is studied. Although the CP‐DRA using a rectangular dielectric body requires a simple fabrication process, the excitation condition for a circular polarization is not clear yet. This paper studies a design method for a CP‐DRA generating a circular polarization with one probe placed at the external location of a rectangular dielectric body. As the first step of the design, the procedure used in the design of a conventional circularly polarized microstrip antenna is applied to this CP‐DRA. In the second stage of the design, an optimum structure of the CP‐DRA generating a circular polarization with matching to a feed system is determined by an iterative analysis of the structure including the excitation section by means of the modal polarization current model method (M‐PCMM). It is shown in the second stage of the design that the M‐PCMM is useful. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 87(11): 1–10, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.10216
Synthesis and Reactions of 3‐Oxobutyl Isothiocyanate (OB ITC)
Authors: Verma Rajeshwar P. 
Published: May 2004

AbstractIn this review an attempt has been made to compile all the existing comprehensive literature for the synthesis of 3‐oxobutyl isothiocyanate (OB ITC), also known as 4‐isothiocyanato‐2‐butanone, and its reactions with compounds possessing different functional groups, such as amines, diamines, amino alcohols, amino thiols, amino phenols, amino thiophenols, and amino acids. The peculiar behavior of OB ITC is due to its sensitivity towards acids, different products being obtained when the reaction is performed in the absence and in the presence of an acid. The pH of the reaction conditions also plays an important role. Normally, OB ITC gives thiourea derivatives when treated with amines, but reactions become interesting with compounds possessing an amino group together with another functional group (NH2, OH, SH, COOH) in the ortho position, providing condensed bicyclic or tricyclic heterocycles of biological importance, with ring nitrogen and/or sulfur. (© Wiley‐VCH Verlag GmbH & Co KGaA, 69451 Weinheim, Germany, 2003)
Thiourea as a Precursor to Sophisticated Heterobicyclic Compounds by a Double Annulation Reaction
Authors: Landreau Cyrille , Deniaud David , Reliquet Alain , Meslin Jean Claude 
Published: May 2004

AbstractWe report here the first example of an efficient regioselective synthesis of heterobicyclic compounds using thiourea as starting material. The key step in this synthetic process is the preparation of N,N′‐bis[(dimethylamino)methylene]thiourea (1), which reacts as thiazadiene, leading to diazadiene heterocycles. These heterocycles give either thiazolopyrimidine 4 or imidazo‐1,3‐thiazine 7 by a double annulation reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Preparation of Acyloins by Cerium‐Catalyzed, Direct Hydroxylation of β‐Dicarbonyl Compounds with Molecular Oxygen
Authors: Christoffers Jens , Werner Thomas , Unger Sven , Frey Wolfgang 
Published: May 2004

AbstractWe report the metal‐catalyzed α‐hydroxylation of a variety of cyclic and acyclic β‐dicarbonyl compounds by molecular oxygen. The decisive advantage of this new method is the use of catalytic amounts of the nontoxic cerium salt CeCl3·7H2O in 2‐propanol at ambient temperature. Most of the cyclic substrates 4a−4i give high yields of analytically pure products 5a−5i, and the workup procedure is simple filtration through silica gel. The oxidation of acyclic dicarbonyl compounds 4j−4p, however, is accompanied by side reactions and decomposition, reducing the yields of products 5j−5p significantly. A proposed mechanism is in agreement with experimental results, in particular the observed oxygen uptake. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Preparation of Oxocanes by Electrophilic Cyclizations of Unsaturated Alcohols in the Presence of Bis(collidine)halonium(I) Hexafluorophosphates
Authors: Mendès Christelle , Renard Sylvie , Rofoo Mazin , Roux Marie‐Claude , Rousseau Gérard 
Published: May 2004

Abstract7‐Octen‐1‐ols substituted in the sp3−sp3 carbon chain with carbocyclic (phenyl and cyclopropane) and heterocyclic (epoxide and dioxolane) moieties were prepared and their cyclizations in the presence of bis(collidine)iodonium(I) and ‐bromonium(I) hexafluorophosphates as electrophiles were studied. Oxocanes were obtained in modest to good yields when a rigid cyclic moiety (cyclopropane or phenyl) was present in the chain, while yields of cyclizations were lower if the cyclic component had a certain flexibility (dioxolane). Low yields were obtained with substrates bearing an epoxide substituent, probably because of stability problems due to the presence of collidine. With the vinylcyclopropane alcohol 12 we observed mainly the opening of the cyclopropane ring and the cyclization produced a tetrahydropyran derivative. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Formation of Cyclobutylidenepyrazolines by Methanolysis of 6‐(2,3,3‐Trifluorocyclobutenyl)‐4,5‐diazaspiro[2.4]hept‐4‐ene
Authors: Guseva Ekaterina V. , Volchkov Nikolay V. , Tomilov Yury V. , Averkiev Boris B. , Nefedov Oleg M. 
Published: May 2004

AbstractThe reaction of 6‐(2,3,3‐trifluorocyclobutenyl)‐4,5‐diazaspiro[2.4]hept‐4‐ene with NaOMe in MeOH results in a mixture of isomeric (6E)‐ and (6Z)‐6‐(2‐fluoro‐3,3‐dimethoxycyclobutylidene)‐4,5‐diazaspiro[2.4]hept‐4‐ene due to the formal substitution of methoxy groups for two geminal fluorine atoms. Both of the isomers selectively add acetyl chloride at the azo‐olefin unit to give 4‐acetyl‐6‐(1‐chloro‐2‐fluoro‐3,3‐dimethoxycyclobutyl)‐4,5‐diazaspiro[2.4]hept‐4‐ene as the trans‐isomer in greater than 95% yield. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2003)
1‐Aryl‐3‐(dimethylamino)propenones: Strong Proton Acceptors for Hydrogen Bonds
Authors: Pleier Anna‐Katharina , Herdtweck Eberhardt , Mason Sax A. , Thiel Werner R. 
Published: May 2004

AbstractBecause of the electron‐donating effects of their terminal dimethylamino groups, the carbonyl units of 1‐aryl‐3‐(dimethylamino)prop‐2‐en‐1‐ones are excellent proton acceptors. Intra‐ and intermolecular hydrogen bonds formed by these species were investigated by structural techniques (X‐ray and neutron diffraction), spectroscopy, and density functional calculations. Co‐crystallization of a derivative bearing three (dimethylamino)prop‐2‐en‐1‐one units attached at one center in the presence of different proton donors produced one‐ and two‐dimensional H‐bridged polymers. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Synthesis of Novel 2‐O,3′‐N‐Linked Macrocyclic Taxoids with Variable Ring Size
Authors: Querolle Olivier , Dubois Joëlle , Thoret Sylviane , Dupont Christophe , Guéritte Françoise , Guénard Daniel 
Published: May 2004

AbstractA series of macrocyclic taxoids was prepared by connecting the 2‐OH and 3′‐NH moieties with aliphatic chains to mimic the docetaxel solid‐state conformation. The synthesis was achieved by acylation of both positions with various bromoalkanoic acids, and ring closure was carried out with sodium sulfide. Nine 19‐ to 27‐membered macrocyclic taxoids were obtained and evaluated as inhibitors of microtubule disassembly as well as for their cytoxicity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
A New and Productive Route to 1‐Heteroarylcyclopropanols
Authors: Belov Vladimir N. , Savchenko Andrei I. , Sokolov Viktor V. , Straub Alexander , Meijere Armin de 
Published: May 2004

Abstract(E/Z)‐2‐(1‐Allyloxycyclopropyl)‐3‐methoxyacrylonitrile (4‐All) was designed and prepared in five steps (58% overall yield) from ethyl cyclopropylidenacetate as a valuable precursor to various 1‐heteroarylcyclopropanols. Its condensation with amidines, guanidine, hydrazine, and methyl thioglycolate and subsequent removal of the allyl protecting group yields 1‐heteroarylcyclopropanols such as 1‐OH (36% over 2 steps), a very potent NO‐independent stimulator of soluble guanylate cyclase. Direct cleavage of the allyl ether protecting group [by palladium‐catalyzed substitution with lithium p‐toluenesulfinate in AcOH or treatment with c‐HexMgBr/Ti(OiPr)4] gives highly functionalized, sterically congested 1‐heteroarylcyclopropanols 29, 30, and 34 with intact amino and ester groups. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)