bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of the linear dimensions of the ovary, determined using sonography, in an age aspect
Authors: Balandin A. A. , Kobeleva A. S. , Balandina I. A. 
Published: January 2024

Aim of the study was to carry out a comparative analysis of the linear size of the right and left ovaries, determined using sonography in women in adolescence, the elderly, and old age.Material and methods. The study was based on the results of ultrasound examination of 84 women with normal pelvic dimensions who were examined at the gynecology department of the Perm Krai Clinical Hospital during the period 2021–2022 in order to exclude probable pathology of the reproductive system. Measurement of longitudinal (length), transverse (width), and anteroposterior (thickness) dimensions of the ovary was performed using transvaginal access. Women were divided into three groups: the first consisted of 28 adolescents (16 to 20 years old), the second – 29 elderly persons (56 to 74 years old), the third – 27 seniors (75 to 85 years old).Results. When comparing the indicators of ovarian size, their statistically significant decrease by old age was revealed. Right ovary length from adolescence to the old age decreased by 20.56 % (p < 0.01), left – by 28.62 % (p < 0.01). Right ovarian width becomes smaller by 20.87 % (p < 0.01) in elderly age and by 26 % (p < 0.01) in senile age, left – by 20.8 % (p < 0.01) and by 28.32 % (p < 0.01), respectively, the anteroposterior dimension of the right ovary – by 23.2 % (p < 0.01) and by 38.8 % (p < 0.01), of the left ovary – by 31.19 % (p < 0.01) and by 39 % (p < 0.01), respectively.Conclusions. The results obtained allow us to expand our understanding of the features of the age-related structure of the ovaries and further continue their detailed study, since new knowledge is needed to develop modern methods for the prevention of pathology of the female reproductive system and the timely provision of quality medical care.
Effect of new antitumor compounds based on azoloazine derivatives on the level of DNA damage in normal Vero cells in the DNA comet test
Authors: Al-Humairi A. H. , Speranskiy D. L. , Minakova M. Yu. , Cherdyntseva N. V. , Udut V. V. 
Published: January 2024

The aim of the work is to study the effect of new azoloazine derivatives on the level of DNA damage to Vero cells (DNA comet test) in vitro by alkaline gel electrophoresis.Material and methods. The objects of the study are 8-(piperidinocarbonyl)3-cyclohexylimidazo[5,1-d][1,2,3,5]tetrazine-4(3H)-one (1), diethyl ether 4-aminoimidazo[5,1-c][1,2,4]triazine3,8-dicarboxylic acid (2), 4-amino-8-ethoxycarbonylimidazo[5,1-c][1,2,4]triazine-3-N-(p-toluyl)carboxamide (3). Epirubicin was chosen as a comparison drug. The compounds were used in doses of 1/2, 1/10 and 1/50 IC50. The Vero cell line cultured according to the standard protocol was selected as the cell model. To assess genotoxicity, an alkaline version of the DNA comet method was used, which has a high sensitivity and allows detecting DNA damage.Results. Analysis of the data obtained indicates that the tested compounds 1-3 enhance DNA damage in non-tumor cells. Compound 1 has the most pronounced genotoxic effect. Thus, the use of this substance in a dose of ½ IC50 led to a significant increase in the length of the comet’s tail by 1.5 times. It was noted that DNA damage under the action of compound 1 in the studied doses and of epirubicin was on the same level.Conclusions. The results obtained prove that compounds 1-3 may have a potentially carcinogenic effect. However, this assumption requires further in-depth experimental studies.
Phenotypic features of rib cartilage cells in funnel-shaped chest deformity
Authors: Strokova E. L. , Pakhomova N. Yu. , Shevchenko A. I. , Korytkin A. A. , Kozhevnikov V. V. , Zaidman А. M. 
Published: January 2024

Funnel-shaped deformity of the chest is a serious disease with an unknown etiology and pathogenesis. Pathological changes occurring in the cartilaginous tissue of the ribs are one of the leading mechanisms for the development of chest curvature. Analysis of the phenotypic features of cells isolated from the site of localization of the pathological process will create a more complete picture of the deformation development.Aim of the study was to identify the phenotype of rib cartilage cells in funnel-shaped deformation of the thorax.Material and methods. Rib cartilage cells of children with funnel-shaped chest deformity were cultured up to the 2–3rd passage, then were identified by histochemical and immunohistochemical methods.Results and discussion. The study revealed cells of two different phenotypes. The first type is oval and polygonal chondroblasts expressing a marker of chondrogenic differentiation. The second type is the cells of the neural phenotype with the expression of early neural markers Musashi1 and PAX6 and the neurospecific protein III β-tubulin, as well as the substance Nissl.Conclusions. The analysis of the phenotypic features of rib cartilage cells with funnel-shaped curvature of the chest allowed us to expand the idea of a possible etiological factor in the deformation development.
Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis
Authors: Shcherbakov V. I. , Obukhova O. O. , Ryabichenko T. I. , Skosyreva G. A. , Gorbenko O. M. , Kosyanova T. G. 
Published: January 2024

The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy.
DIGITALISING HALAL CERTIFICATION: The Dynamic of Regulations and Policies Concerning Halal Certification in Indonesia
Authors: Santoso Lukman , Rachman Abdul 
Published: January 2024

The global halal product market is proliferating, fuelling increased demand for quality halal products. To fulfil halal certification requirements, Micro, Small and Medium Enterprises (MSMEs) in East Java Province, Indonesia face challenges in the certification process which is manual, time-consuming and inefficient. To overcome these problems, this study aims to explore the urgency of digitalising halal certification for optimal impact on improving the quality of halal products for MSMEs in East Java. This research employed a qualitative
method with a literature and conceptual juridical approach. This research used primary and secondary data, namely BPJPH data, the Office of Cooperatives and SMEs of East Java Province. The results of this study indicate that government regulations and policies related to halal certification provide legal certainty for digital transformation in the implementation of halal certification in East Java Province. Although the achievements of MSMEs in East Java Province are low compared to those of other provinces, the digitalisation of halal certification can effectively help the MSMEs in East Java Province to reduce costs, expedite halal certification processing time, and increase compliance with halal requirements so that acceleration and increase in the number of halal certifications for MSMEs can take place properly.

Pasar produk halal global terus berkembang dengan pesat dan mendorong peningkatan permintaan terhadap produk halal yang berkualitas. Untuk memenuhi persyaratan sertifikasi halal, Usaha Mikro, Kecil, dan Menengah (UMKM) di Provinsi Jawa Timur, Indonesia menghadapi tantangan dalam proses sertifikasi yang manual, memakan waktu, dan kurang efisien. Untuk mengatasi masalah tersebut, penelitian ini bertujuan mengeksplorasi urgensi digitalisasi sertifikasi halal sehingga berdampak optimal terhadap peningkatan kualitas produk halal UMKM di Jawa Timur. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan netnografi dan yuridis konseptual. Penelitian ini menggunakan data hasil wawancara dengan pegiat sertifikasi halal dan data dari situs BPJPH, Dinas Koperasi dan UKM Provinsi Jawa Timur. Hasil penelitian ini menunjukkan bahwa regulasi dan kebijakan pemerintah terkait sertifikasi halal memberikan kepastian hukum terhadap transformasi digital dalam pelaksanaan sertifikasi halal di Provinsi Jawa Timur. Walaupun capaian pelaku UMKM di Provinsi Jawa Timur tergolong rendah dibandingkan dengan provinsi lainnya, namun digitalisasi sertifikasi halal efektif dapat membantu UMKM Provinsi Jawa Timur untuk mengurangi biaya, mempercepat waktu sertifikasi halal, dan meningkatkan kepatuhan terhadap persyaratan halal sehingga percepatan dan peningkatan jumlah sertifikasi halal bagi UMKM dapat terlaksana dengan baik.
The Relationship Between Religiosity and Self-Compassion in Breast Cancer Patients Post Mastectomy Surgery
Authors: Sandy Nisa Nabila , Hakam Mulia , Murtaqib Murtaqib 
Published: January 2024

In Indonesia, the prevalence of breast cancer is quite high, from report data (Riskesdas, 2018) stating that breast cancer reaches 42.1% with an average death rate of around 17%. The type of treatment that is often used by breast cancer patients is a mastectomy. Masectomy raises physical and psychological impact. The current phenomenon is that many women experience some level of psychosocial pressure during their cancer journey, which can have an impact on issues of faith or religiosity, self-compassion, and quality of life (Hewit et al, 2019). The research design conducted by researchers is observational analytic with a cross sectional approach. The population in this study were breast cancer patients after mastectomy surgery at Dr. Soebandi Jember and the sample of this study were 38 respondents. The religiosity analysis in this study found that the religiosity study of patients who experienced breast cancer post-masectomy surgery obtained that the median value of the religiosity variable was 60.00 with the lowest value being 23 and the highest being 64. Meanwhile, the self-compassion analysis found that self-compassion research on patients who experienced breast cancer after mastectomy surgery found that the median value of the self-compassion variable was 94.50 with the lowest value being 65 and the highest being 98. Analysis using Pearson Product moment obtained a p-value of 0.000 less than 0.05 so that the Ha hypothesis is accepted or it can be said that there is a relationship between religiosity and self-compassion in post-massectomy breast cancer patients at Dr. Soebandi Jember.
Family characteristics and income: Evidence from Indonesia
Authors: Firdaus Husban Yarjuna , Satrio Aham Bagas , Fahrudin Muhammad Safli , Siregar Muhammad Adam 
Published: January 2024

<div data-canvas-width="597.4487772549016">Balance in the form of linkages between socioeconomic aspects of a region is the key to economic stability. This economic stability is essential to achieve community welfare, so existing interventions must be considered considering that a slight change in one aspect will affect the economic balance. With the achievement of community welfare, the economic development of a region can be said to be good, which also has implications for handling existing socioeconomic problems. However, the misalignment of education level, gender, internet access, and marital status of each district/city area triggers differences in income levels. Therefore, through this study, it is expected to be able to answer whether factors such as education level, gender, internet access, and marital status are factors that influence the magnitude of income levels, especially in DIY Provinces. By using IFLS-5 data processed through an estimat ion method using logistic regression, test results were obtained that gender and internet access factors significantly affected the amount of people's income. In contrast, the level of education and marital status did not significantly affect the income of people in DIY Province</div>
Neoadjuvant Immunotherapy combined with Chemoradiotherapy VS. Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma(cStageII-III): Study Protocol For A Multi-center Prospective Randomized Clinical Trial
Authors: Huang Xu , Tang Han , Jiao Heng , Yin Jun , Wang Hao , Xu Wenyi , Yin Hao , Yang Shuyi , Wang Qingle , Zeng Mengsu , Jiang Dongxian , Hou Yingyong , Du Shisuo , Zeng Zhaochong , Li Yin , Chen Keneng , Li Zhigang , Han Yongtao , Shen Weiyu , Chen Qixun , Jiang Hongjing , Fan Hong , Jiang Bo , Liao Yongde , Tan Lijie 
Published: January 2024

Abstract
Background
Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been suggested as the standard treatment for locally advanced ESCC. Meanwhile, CHECKMATE-577 has suggested that immunotherapy may be effective in controlling tumor recurrence and metastasis. According to PALACE-1, Neoadjuvant radiotherapy and chemotherapy combined with immunity may be more beneficial for patients. Therefore, it is meaningful to further study whether the combination of nCRT and immunotherapy has better effects in the treatment of ESCC.
Methods
NCT04973306 is designed as a multicenter, prospective, randomized, Phase II/Phase III clinical trial discussion, investigating the safety and efficacy of nCRT plus tumor immunotherapycompared with nCRT. A total of 476 patients with locally advanced resectable ESCC (stage cII-III) are randomly assigned to neoadjuvant immunotherapy combined with chemoradiotherapy (arm A) or nCRT (arm B) with a 1:1 allocation ratio. The primary endpoint of the first phase of the study was pCR. Overall survival assessed with a minimum follow-up of 36 months served as the study's main goal during the second phase (OS). Secondary outcomes are R0 resection rate, positive lymph node rate and response, number of lymph nodes cleared, tumor regression grade (TRG) of primary tumor, and disease-free survival (DFS) between the two groups
Discussion
This trial aims to study whether nCRT plus tumor immunotherapy yields superior benefits for curative treatment of ESCC and the survival. Trial registration number is NCT04973306.
Early warnings of bee colony failure
Authors: Colin Théotime , Dakos Vasilis , Barron Andrew , Meikle William , Altmann Eduardo , Latty Tanya 
Published: January 2024

Abstract
How to identify ecological systems at risk of failure is a central question of modern biology and agriculture. Due to human impacts and global change, there is a growing need for early warning signals that identify when an ecological system is at risk of a state change before those changes become irreversible or extremely complex and costly to remediate. Honeybees (Apis mellifera) are an urgent case because our food crops heavily rely on them for pollination and annual bee colony losses reported by beekeepers across the globe are unsustainable. Given enough warning, beekeepers can rescue dying colonies, but early warning signals of death for individual bee colonies are lacking. Here we used early warning signals to investigate whether fluctuations and dynamical patterns in internal hive temperature can be used as an early indicator of impending colony failure. Across three distinct datasets we found that temperature regulation of failing colonies was different enough to distinguish them from healthy colonies weeks before they died. This signal comes early enough to intervene and assist colonies with standard beekeeping practices. Our study shows that early warning theory can help to identify practical signals of risk of state change even in systems that change state relatively rapidly, such as a dying bee colony, early enough to intervene and prevent losses.
A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation.
Authors: Wyneken Ursula , Yantén-Fuentes Liliana , Pizarro Matías , Rojas Carolina , Pradenas Carolina , Corvalán Katherine , Bustos Gonzalo , Luarte Alejandro , Batiz Federico , Luz-Crawford Patricia , Pino-Lagos Karina 
Published: January 2024

Abstract
The connection between stress-induced mood disorders and inflammatory bowel diseases has long been acknowledged. Here, we hypothesize that psychological stress may regulate intestinal inflammation under stress conditions through the release of small extracellular vesicles derived from astrocytes (AsEVs). Sprague-Dawley rats were stressed by movement restriction. In-utero electroporation was performed to express a recombinant protein (BAP-TM) in astrocytes that is exported in AsEVs. AsEVs were also obtained from primary astrocyte cultures that were stimulated with DMSO or corticosterone (to emulate a stress condition). The inflammatory status in the blood and intestine was assessed by flow cytometry and histology, respectively. We found that recombinant AsEV proteins expressed in brain astrocytes as well as AsEVs harvested from primary astrocyte cultures contain the gut homing receptor CCR9 and target the small intestine in rats. At the histological level, inflammatory parameters (such as lymph vessel diameter or cell number in them) induced by movement restriction are restored to normal levels by treatment with AsEVs derived from primary astrocytes. On the contrary, AsEVs derived from corticosterone-treated astrocytes increase stress-induced intestinal inflammation. Furthermore, AsEVs can modulate the immune balance of the GALT: while AsEVs derived from control astrocyte cultures favor an anti-inflammatory profile (i.e., increased Treg/Th17 ratio), AsEVs derived from corticosterone-treated astrocytes have an opposite action. We here reveal an entirely new brain-to-gut AsEVs-mediated communication pathway that may impact on stress-induced inflammatory bowel pathophysiology. This research paves the way for novel, cutting-edge therapeutic approaches to tackle the complex interplay between stress and intestinal inflammatory diseases.
Nonlinear resonant responses of suspended cables with a longitudinal time-delayed feedback control
Authors: Peng Jian , Li Luxin , Hu Xia , Xie Xianzhong , Lenci Stefano 
Published: January 2024

Abstract
In this study, the vibration control of suspended cables is achieved through the implementation of a longitudinal time delay feedback control strategy. Based on the Hamiltonian variational principle and using boundary conditions, the motion differential equations for the suspension cable under longitudinal time-delayed feedback control are derived. The delay differential equations are discretized using the Galerkin method. The fourth-order approximate solution for the primary resonance response of the suspension cable under time-delayed feedback control is obtained using the method of multiple scales. The correlation between the system response and the controlled parameters is established, and the vibration control effects under different control parameters are analyzed through numerical examples.
From Tradition to Innovation: IoT-Enabled Precision Farming Strategies for Optimal Resource Use efficiency in Tomato Crop Management
Authors: Kaliannan Nirmal , Sabapathi Naveen Latha , Ranjan Sushant , Prabhakar Varun , Salimath Mahesh 
Published: January 2024

Abstract
This study investigates the response of two varieties of plants, Sahoo and SVTD8323, to different fertilizer treatments. The Sahoo variety showed a quick response to the fertilizer treatments, with F1 and F2 treatments resulting in a 17% and 26% increase in plant height at 40 DAT, respectively. Both varieties showed an increase in the number of branches, with F2 treatment resulting in a 24% and 26% increase in Sahoo and SVTD8323, respectively. Both the varieties showed an increase in fruit weight, with Sahoo showing a 5.8% and 7.9% increase in fruit weight over the control at F1 and F2 treatment, respectively, while SVTD8323 showed a 2.9% and 5.5% increase in fruit weight over the control at F1 and F2 treatment, respectively. Both varieties followed a parabolic curve in yield per harvest across treatments, with Sahoo showing a 12.5% increase in yield at F1 treatment and a 13.5% increase at F2 treatment over the control treatment. Similarly, SVTD8323 showed a 12.5% increase in yield at F2 treatment over the control treatment. In a nutshell both the varieties consumed 29 to 39% lesser water and 25% lesser fertilizer than respective control treatment. The benefit to cost ratio was highest at F2 treatment in both varieties, with a ratio of 2.14 in Sahoo and 2.27 in SVTD8323, indicating that the IoT enabled precision farming profitable.
Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Authors: Monistrol-Mula Anna , Diaz-Torres Santiago , Felez-Nobrega Mireia , Haro Josep Maria , Medland Sarah , Mitchell Brittany 
Published: January 2024

Abstract
Current literature suggests that people with psychiatric disorders have higher risk of SARS-CoV-2 infection and a worse prognosis of the disease. We aimed to study the genetic contribution to these associations in a range of psychiatric disorders and COVID-19, and determine whether these are unique or shared across psychiatric disorders. Using the largest available genome-wide association studies, we analysed the genetic overlap between six psychiatric disorders and COVID-19. We further identified specific regions of the genome that are shared across the psychiatric disorders and COVID-19 using pairwise GWAS, and examined which genes are present in these regions. Finally, we sought evidence for causal associations using Mendelian Randomization methods. We found a significant genetic overlap between depression and ADHD, with both COVID-19 susceptibility and severity, as well as between anxiety and COVID-19 severity. We identified specific regions of the genome shared between several psychiatric disorders and COVID-19. However, no region was common across all psychiatric disorders and COVID-19. Gene-based analysis in these genomic regions suggested possible links with immune-related pathways such as thyroid homeostasis, inflammation and stress response. Finally, we provide evidence of a potential causal relationship between ADHD and higher COVID-19 susceptibility and severity, and between depression and higher susceptibility to COVID-19. Our results support the hypothesis that the relationship between psychiatric disorders and COVID-19 risk is likely due to shared alterations in immune-related pathways and are not as a result of environmental factors alone, shedding light on potentially viable therapeutic targets.