bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen peroxide–induced DNA damage and DNA repair in lymphocytes from malnourished children
Authors: González C. , Nájera O. , Cortés E. , Toledo G. , López L. , Betancourt M. , Ortiz R. 
Published: August 2002

AbstractThe aim of this study was to assess DNA repair capacity in lymphocytes of children with protein calorie malnutrition using the single‐cell gel electrophoresis (comet) assay. Repair capacity was assessed by estimating the relative decrease of DNA migration length 5, 15, 30, and 60 min after hydrogen peroxide treatment, in three groups of children: well‐nourished (WN), well‐nourished infected (WN‐I), and malnourished infected (MN‐I). In addition, the DNA migration length was evaluated in all groups before and after peroxide treatment. Comparison of mean migration lengths observed in WN and WN‐I children showed significant differences at all times tested; between WN‐I and MN‐I differences were also observed, except after hydrogen peroxide exposure. This implies that lymphocytes of WN‐I and MN‐I children were equally sensitive to hydrogen peroxide. Nevertheless, the MN‐I group clearly shows the greatest overall percentage of damaged cells at all times tested. In relation to repair capacity, at 5 min it was approximately 30% in both groups of well‐nourished children, but only 20% in MN‐I; 15 min after exposure, repair capacity increased to 51% in well‐nourished children but only to 31% in MN‐I; and at 60 min this capacity increased to 82% in well‐nourished but only to 55% in MN‐I. These data indicate that lymphocytes of malnourished children show a decreased capacity to repair hydrogen peroxide–induced DNA damage compared to that of well‐nourished controls. This reflects that only malnutrition is associated with decreased DNA repair capacity. Additionally, the data confirm that severe infection and malnutrition are two factors clearly associated with increased DNA damage. Environ. Mol. Mutagen. 39:33–42, 2002 © 2002 Wiley‐Liss, Inc.
DNA adducts of 1,3‐butadiene in humans: Relationships to exposure, GST genotypes, single‐strand breaks, and cytogenetic end points
Authors: Zhao Chunyan , Vodicka Pavel , Sram Radim J. , Hemminki Kari 
Published: August 2002

AbstractThe modulation of 1,3‐butadiene (BD)‐induced DNA adducts by occupational exposure, glutathione S‐transferase (GST) genotypes, single‐strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 nonsmokers and 4 smokers. Among all subjects, the adduct levels in workers lacking GSTM1 were significantly higher than in those who were GSTM1 positive (P = 0.026), and individuals with combined GSTM1(−) and GSTT1(+) genotype had elevated level of adducts compared to that of persons with GSTM1(+) and GSTT1(+) (P = 0.049). The increase in BD–DNA adduct levels in all subjects was significantly related to BD exposure and GSTM1 genotype (linear multiple regression analysis, P = 0.001; P = 0.035). The results suggest that DNA adducts serve as a sensitive and specific biomarker, integrating exposure and host metabolic capacity, although the data are limited to a small number of subjects. Environ. Mol. Mutagen. 37:226–230, 2001. © 2001 Wiley‐Liss, Inc.
The use of distance sampling and mark‐resight to estimate the local density of wildlife populations
Authors: Focardi Stefano , Isotti Roberto , Pelliccioni Elisabetta Raganella , Iannuzzo Daniele 
Published: August 2002

AbstractWe used distance sampling (line transects) and mark‐resight to estimate habitat and local area (area size, range: 3.9–44.5 ha) population density of ungulates. The distance sampling study was performed on fallow deer (Dama dama), roe deer (Capreolus capreolus) and wild boar (Sus scrofa) in a mediterranean forest. The mark‐resight study was performed on a roe deer population in a hilly area of the Apennines. The first study allowed us to estimate the animal density into four different habitats (deciduous oak wood, evergreen oak wood, maquis and open areas with domestic‐pine woods). The between habitat differences of population density are large for the three species: fallow deer are more abundant in the open areas (22.22 heads/km2, c.i. 12.42–39.74), roe deer in the deciduous oak wood (14.50 heads/km2, c.i. 7.01–30.10) and wild boar in both the open areas (11.29 heads/km2, c.i. 4.86–26.20) and evergreen oak wood (10.42 heads/km2, c.i. 6.78–16.02). The roe deer population in the Apennines is characterized by large between‐zone variations of population density (range: 1997: 13.25–131.31, 1998: 29.06–78.01, 1999: 10.67–88.58). Moreover, trends of local zones may be quite different with respect to the average trend of a wider study area, suggesting a well‐defined short‐scale spatial structure for this population. We conclude that both survey methods may be very useful in population assessment, but they need intense field effort and careful statistical design. Care needs to be taken to satisfy the assumptions of the statistical models. Copyright © 2002 John Wiley & Sons, Ltd.
Eating disorders, attachment and interpersonal difficulties: a comparison between 18‐ to 24‐year‐old patients and normal controls
Authors: Broberg Anders G. , Hjalmers Ingrid , Nevonen Lauri 
Published: August 2002

AbstractThis study tested the connection between eating disorder symptoms, insecure attachment, and other interpersonal difficulties. The sample consisted of 145 female patients (aged 18 to 24 years), who had attended an outpatient clinic for eating disorders in the city of Göteborg, Sweden, and 315 women chosen at random from the city's Population Register. Subjects filled in the Relationship Questionnaire (Bartholomew and Horowitz, 1991) and the Eating Disorders Inventory‐2 (Garner, 1991). The results confirm the link between eating disorders, insecure attachment and interpersonal problems that has been found in other studies, and extends it to women in the normal control group who report that they have previously had eating disorder problems. Our results further indicate that severity of eating disorders problems is related to security of attachment, whereas type of eating disorder is related to scores on the psychological subscales of the EDI‐2. The implications for psychological treatment are discussed. Copyright © 2001 John Wiley & Sons, Ltd and Eating Disorders Association.
Modelling the Quaternary evolution of shore platforms and erosional continental shelves
Authors: Trenhaile A. S. 
Published: August 2002

AbstractA mathematical model was used to investigate the effect of glacially induced fluctuations in sea level on the evolution of wave‐cut shore platforms and erosional continental shelves during the Quaternary. The model used two deep‐water wave sets, which were used to calculate breaker height and depth, and the force of the waves at the waterline, according to the width and bottom roughness of the surf zone and the gradient of the submarine slope. The model also incorporated an erosional threshold related to the strength of the rocks, the number of hours each year in which the water level is at each intertidal elevation and the amount and persistence of the debris at the cliff foot. Most runs were made using a sea level model that consisted of 26 glacial cycles from 2 million to 0·9 million years ago, and nine, of approximately twice the amplitude and wavelength, in the last 0·9 million years. The model emphasized the dynamic association between the contemporary intertidal platform and the continental shelf. Both surfaces trend towards a state of static equilibrium under oscillating sea level conditions, when attenuated waves are unable to continue eroding the rock. If there has not been enough time to reduce the gradient of the shallower portions of the continental shelf, however, intertidal shore platforms can be in a temporary, though possibly long‐lasting, state of dynamic equilibrium. The model suggests that most platforms are, at least in part, inherited from one, or in many cases more, interglacial stages when sea level was similar to today's. Copyright © 2001 John Wiley & Sons, Ltd.
On the correspondence between morphological and hydrodynamical patterns of groyne fields
Authors: Sukhodolov Alexander , Uijttewaal Wim S. J. , Christof Engelhardt  
Published: August 2002

AbstractThis paper examines a variety of recirculation flow patterns that develop in the groyne fields on rivers. A comprehensive data set was obtained from flume experiments at Delft University of Technology and field measurements performed on the Elbe River in Germany. The analysis focuses on patterns of velocity, scour and deposition, and corresponding change of riverbed morphology. The results show that velocity patterns in the groyne fields depend mainly on the aspect ratio between groyne length and length of groyne field. When the aspect ratio is greater than 0·5, a one‐gyre pattern of recirculation develops, while at groyne fields with aspect ratios less than 0·5 a two‐gyre recirculation pattern emerges. The spatial distribution of fine‐sediment deposition between the groynes coincides with the locations of gyres. Moreover, the thickness of the fine‐sediment layer decreases toward the gyre margins where recirculation velocities are greatest. Although the total concentration of suspended sediment in the river does not change considerably as the flow moves through the groyne field, the biological and gravimetrical composition of the suspended material changes substantially within the groyne field. These changes are due to preferential deposition of coarse mineral particles and the replacement of those minerals with finer organic material. Copyright © 2002 John Wiley & Sons, Ltd.
Volatile leaf oil constituents of Cymbopogon citratus (DC) Stapf
Authors: Kasali Adeleke A. , Oyedeji Adebola O. , Ashilokun Adeolu O. 
Published: August 2002

AbstractThe composition of the essential oil of the leaf of Cymbopogon citratus (DC) Stapf, growing on the campus of Lagos State University, was determined by the use of GC and GC–MS. The oil gave 27 peaks, amounting to 98% of the total oil. Twenty‐three (97.3%) constituents were identified. The main constituents were geranial (33.7%), neral (26.5%) and myrcene (25.3%). Small amounts of neomenthol (3.3%), linalyl acetate (2.3%), Z‐β‐ocimene (1.0%) and E‐β‐ocimene were also detected. Copyright © 2001 John Wiley & Sons, Ltd.
On the influence of numerical schemes and subgrid–stress models on large eddy simulation of turbulent flow past a square cylinder
Authors: Nakayama A. , Vengadesan S. N. 
Published: August 2002

AbstractInfluence of finite difference schemes and subgrid‐stress models on the large eddy simulation calculation of turbulent flow around a bluff body of square cylinder at a laboratory Reynolds number, has been examined. It is found that the type and the order of accuracy of finite‐difference schemes and the subgrid‐stress model for satisfactory results are dependent on each other, and the grid resolution and the Reynolds number. Using computational grids manageable by workstation‐level computers, with which the near‐wall region of the separating boundary layer cannot be resolved, central‐difference schemes of realistic orders of accuracy, either fully conservative or non‐conservative, suffer stability problems. The upwind‐biased schemes of third order and the Smagorinsky eddy‐viscosity subgrid model can give reasonable results resolving much of the energy‐containing turbulent eddies in the boundary layers and in the wake and representing the subgrid stresses in most parts of the flow. Noticeable improvements can be obtained by either using higher order difference schemes, increasing the grid resolution and/or by implementing a dynamic subgrid stress model, but each at a cost of increased computational time. For further improvements, the very small‐scale eddies near the upstream corners and in the laminar sublayers need to be resolved but would require a substantially larger number of grid points that are out of the range of easily accessible computers. Copyright © 2002 John Wiley & Sons, Ltd.
Comparison of spectral and finite element methods applied to the study of the core‐annular flow in an undulating tube
Authors: Kouris Charalampos , Dimakopoulos Yannis , Georgiou Georgios , Tsamopoulos John 
Published: August 2002

AbstractA Galerkin/finite element and a pseudo‐spectral method, in conjunction with the primitive (velocity‐pressure) and streamfunction‐vorticity formulations, are tested for solving the two‐phase flow in a tube, which has a periodically varying, circular cross section. Two immiscible, incompressible, Newtonian fluids are arranged so that one of them is around the axis of the tube (core fluid) and the other one surrounds it (annular fluid). The physical and flow parameters are such that the interface between the two fluids remains continuous and single‐valued. This arrangement is usually referred to as Core‐Annular flow. A non‐orthogonal mapping is used to transform the uneven tube shape and the unknown, time dependent interface to fixed, cylindrical surfaces. With both methods and formulations, steady states are calculated first using the Newton–Raphson method. The most dangerous eigenvalues of the related linear stability problem are calculated using the Arnoldi method, and dynamic simulations are carried out using the implicit Euler method. It is shown that with a smooth tube shape the pseudo‐spectral method exhibits exponential convergence, whereas the finite element method exhibits algebraic convergence, albeit of higher order than expected from the relevant theory. Thus the former method, especially when coupled with the streamfunction‐vorticity formulation, is much more efficient. The finite element method becomes more advantageous when the tube shape contains a cusp, in which case the convergence rate of the pseudo‐spectral method deteriorates exhibiting algebraic convergence with the number of the axial spectral modes, whereas the convergence rate of the finite element method remains unaffected. Copyright © 2002 John Wiley & Sons, Ltd.
A note on rational call option exercise
Authors: Engström Malin 
Published: August 2002

AbstractUsing Swedish equity option data, the rationality in the exercise of American call options is analyzed to see
how well it complies with the theoretical exercise rules. Although the exercise behavior appears to be rational
overall, several cases of both faulty exercise and failure to exercise are found. Almost a third of the early
exercised calls are exercised at other times than predicted by theory. Several of these exercise decisions could
potentially be explained by transaction costs, indicating that market frictions do affect the exercise behavior.
However, over two thirds of the faulty exercises cannot be explained at all. © 2002 Wiley Periodicals, Inc.
Jrl Fut Mark 22:471–482, 2002
Distinct cytogenetic pathways of advanced‐stage neuroblastoma tumors, detected by spectral karyotyping
Authors: Stark Batia , Jeison Marta , Bar‐Am Irit , Glaser‐Gabay Leticia , Mardoukh Jacques , Luria Drorit , Feinmesser Meora , Goshen Yacov , Stein Jerry , Abramov Aya , Zaizov Rina , Yaniv Isaac 
Published: August 2002

AbstractMolecular studies of advanced‐stage neuroblastoma (NBL) have revealed a marked genetic heterogeneity. In addition to MYCN amplification and chromosome 1 short‐arm deletions/translocations detected by conventional cytogenetics, application of fluorescence in situ hybridization has disclosed a high prevalence of 17q gain, whereas allelotyping and comparative genomic hybridization techniques also have revealed loss of 11q and of other chromosomal material. Using the recently developed technique of spectral karyotyping (SKY), we sought to refine the cytogenetic information, identify hidden recurrent structural chromosomal abnormalities, and compare them to the molecular findings. Thirteen samples of metaphase spreads from 11 patients with advanced‐stage NBL were analyzed by SKY. Most of them were found to have complex karyotypes (more than three changes per metaphase) and complex unbalanced rearrangements. Recurrent aberrations leading to 17q gain, deletion of 1p, MYCN amplification, and loss of 11q appeared in 7, 4, 4, and 5 patients, respectively, in simple and complex karyotypes. Chromosome 3 changes and gain of 1q and 7q appeared in 6, 5, and 4 patients, respectively, in complex karyotypes only, reflecting later changes. A strikingly high prevalence of the unbalanced translocation der(11)t(11;17), leading to concomitant 11q loss and 17q gain in 4 patients, delineated a distinct cytogenetic group, none having 1p deletion and/or MYCN amplification. der(11)t(11;17) was associated with complex karyotypes with changes in chromosomes 3 and 7q. The 17q translocations with partners other than 11q were associated with 1p deletion and/or MYCN amplification. The distinct cytogenetic subgroups identified by SKY confirm and extend the recent molecular observations, and suggest that different genes may interact in the der(11)t(11;17) pathway of NBL development and progression. © 2002 Wiley‐Liss, Inc.
Cumulative dosage effect of a RAD51l1/HMGA2 fusion and RAD51l1 loss in a case of pseudo‐Meigs' syndrome
Authors: Amant Frederic , Debiec‐Rychter Maria , Schoenmakers Eric F.P.M. , Hagemeijer‐Hausman Anne , Vergote Ignace 
Published: August 2002

AbstractUterine leiomyoma presenting with ascites and pleural fluid is referred to as pseudo‐Meigs' syndrome. It is unclear whether common uterine leiomyomas and uterine leiomyomas causing pseudo‐Meigs' syndrome are cytogenetically related or whether functionally different primary pathogenetic triggers are responsible for the differences in tumor phenotype. In this study, we investigated the possible involvement of RAD51LI and HMGA2 (formerly known as HMGIC) in initiation and/or progression of a huge uterine leiomyoma presenting as pseudo‐Meigs' syndrome. The detailed cytogenetic and FISH analysis revealed the presence of two subclones with a complex karyotype, 46,XX,t(2;12)(q31;q21),ins(14;12)(q23‐24;q15q21).ish del(12)(q15q15) (LL12NC01‐142H1‐,LL12NC01‐27E12‐),der(12)t(2;12)(LL12NC01‐142H1+,LL12NC01‐27E12‐),der(14)ins(14;12)(q22;q15q15) (LL12NC01‐142H1+,LL12NC01‐27E12+,RAD51LI+), der(14)ins(14;12)(q23‐q24;q15q21) (LL12NC01‐142H1‐, LL12NC01‐27E12+) [20]/46,idem,del(14)(q21q24).ish(RAD51LI‐) [6], indicating intragenic HMGA2 rearrangement and loss of one of the RAD51LI alleles in a derivative subclone with chromosome 14 deletion. Furthermore, RACE and RT‐PCR analysis of the tumor cells did not reveal abnormal HMGA2 or RAD51LI transcripts. Additionally, the cellular subclone with intrachromosomal 14q21‐q24/RAD51LI deletion showed an in vitro growth advantage over the subclone without the deletion. This observation supports a model in which accumulation of two independent mutations—a classical structural rearrangement involving HMGA2 and RAD51L1, in combination with a loss of the second RAD51L1 allele—might play a major role in the development of pseudo‐Meigs' syndrome. © 2001 Wiley‐Liss, Inc.
Evidence for eolian deposition in the sandy uplands of East Texas and the implications for archaeological site integrity
Authors: Frederick Charles D. , Bateman Mark D. , Rogers Robert 
Published: August 2002

AbstractUnconsolidated sands form an extensive mantle across large parts of East Texas uplands. The exact geomorphic processes responsible for their formation are not known, but, on hill summit settings, these deposits are interpreted as either eolian sediments or as sand liberated by thein situweathering of the underlying Tertiary age fluvial‐deltaic sandstone bedrock. In order to identify which of these is the most likely formation process, we used detailed sedimentary analysis coupled with optically stimulated luminescence (OSL) dating of the sediment on seven samples from a single profile in Lee County, Texas. All OSL samples demonstrated that samples had been exposed to significant sunlight before they were deposited in the middle to late Holocene, thereby ruling out anin situweathering origin. These results indicate that eolian sedimentation occurred during the middle to late Holocene and that archaeological sites within these deposits may be in good context and worthy of excavation. © 2002 John Wiley & Sons, Inc.
ESR isochron dating analyses at Bau de l'Aubesier, Provence, France: Clues to U uptake in fossil teeth
Authors: Blackwell Bonnie A.B. , Skinner Anne R. , Blickstein Joel I.B. , Lebel Serge , Leung Helen Y.M. 
Published: August 2002

AbstractAt Bau de l'Aubesier, Provence, Mousterian artifacts and human teeth occur in inhomogeneous (“lumpy”) sedimentary deposits that include bone and tooth fragments and extensive burnt horizons. Electron spin resonance (ESR) isochron analyses of mammal teeth, which use multiple subsamples with different U concentrations, can measure the external dose rate experienced by the tooth regardless of reworking and sedimentary dose rate changes. Isochron analyses do depend on the U uptake model assumed, but can also identify teeth that have experienced secondary U uptake or leaching. Using 11 teeth from six archaeological layers, the isochrons demonstrate that at least three teeth have experienced secondary uptake. For eight teeth, the U uptake has apparently not followed strictly early (EU), linear (LU), or recent uptake (RU), but more closely approximates LU‐RU. Comparing volumetrically averaged sedimentary geochemistry with thermoluminescent dosimetry suggests that fossil tissues in the sediment have also experienced LU‐RU uptake. LU‐RU uptake can explain standard ESR ages that underestimate the true fossil age. © 2001 John Wiley & Sons, Inc.
Neogene exhumation of the Variscan Szeghalom Dome, Pannonian Basin, E. Hungary
Authors: Toóth Tivadar M. , Schubert Feólix , Zachar Judit 
Published: August 2002

AbstractThe Pannonian Basin consists of several deep sub‐basins separated by uplifted basement highs. One of the largest and deepest sub‐basins is the Békés Basin in SE Hungary which is surrounded to the north by several crystalline domes. Of these, the Szeghalom Dome is the best known petrologically, and has been used for studying the Neogene exhumation history of the area.On the basis of metabasite bulk chemistry, the Szeghalom Dome can be subdivided into four distinct zones, the borders of which correspond closely to geophysical anomalies. The four zones exhibit different pre‐Variscan and Variscan pressure–temperature–time (P–T–t) histories. In zone I, high‐pressure relics (600°C, > 12 kbar) occur. Peak‐metamorphic conditions of the main Barrovian overprint were c. 700°C and 6 kbar, and amphibole K/Ar ages scatter around 260 Ma. Zone II shows similar characteristics, with the formation of anatectic granite at peak conditions. K/Ar ages are as low as 220 Ma. Zones III and IV show similar evolution to each other with high‐grade Barrovian relics (700°C), peak metamorphism at 570°C and amphibole ages of 300 Ma.Throughout the dome, fingerprints of a three‐fold Neogene tectonic evolution can be observed. An early detachment fault formed quartz–feldspar–mylonite in zone IV, while chloritic breccia developed at the border of zones II and III. Following the thermal subsidence phase of the basin evolution, the area was dominated geodynamically by the reactivation of older strike‐slip fault systems. These movements were responsible for the horizontal transport of the crystalline blocks at both the southern and northern flanks of the dome. Copyright © 2000 John Wiley & Sons, Ltd.