bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of pension and financial knowledge for pension plan participation in Italy
Authors: Castagno Elisa , Caretta Alessandra , Giacomel Elisabetta , Rossi Mariacristina 
Published: January 2025

Abstract
Due to the implementation of several pension reforms, Italian individuals have to take more complex financial decisions and have more responsibilities on their retirement well-being which also includes the choice of whether to participate in pension funds. Relying on novel survey data, we empirically investigate the effect of pension and financial knowledge on the probability of pension plan participation in Italy. Despite documenting the already well-known trends about disparities in the level of such knowledge, we are able to establish that only pension literacy has a positive and causal effect on the probability to participate in a private pension fund.
ALGEBRAIC CLASSES IN MIXED CHARACTERISTIC AND ANDRÉ’S p-ADIC PERIODS
Authors: Ancona Giuseppe , Frăţilă Dragoş 
Published: January 2025

Abstract
Motivated by the study of algebraic classes in mixed characteristic, we define a countable subalgebra of

${\overline {\mathbb {Q}}}_p$

which we call the algebra of André’s p-adic periods. The classical Tannakian formalism cannot be used to study these new periods. Instead, inspired by ideas of Drinfel’d on the Plücker embedding and further developed by Haines, we produce an adapted Tannakian setting which allows us to bound the transcendence degree of André’s p-adic periods and to formulate the p-adic analog of the Grothendieck period conjecture. We exhibit several examples where special values of classical p-adic functions appear as André’s p-adic periods, and we relate these new conjectures to some classical problems on algebraic classes.
Emergency department use and responsiveness to the palliative care needs of patients with dementia at the end of life: A scoping review
Authors: Vieira Silva Sara , Conceição Paulo , Antunes Bárbara , Teixeira Carla 
Published: January 2025

Abstract

Objectives
More than 50% of patients with dementia visit the emergency department (ED) each year. Patients with dementia experience frequently unrelieved symptoms that can benefit from palliative care. Response to palliative care needs in the ED can be quite challenging and access to palliative care is generally scarce. The aim of this scoping review is to assess ED use and responsiveness to palliative care needs of patients with dementia in their last year of life.

Methods
A scoping literature review following the Joanna Briggs Institute methodology. Electronic search of the literature was undertaken in Medline (PubMed), Web of Science, Scopus, Scielo, and APA PsycInfo, last updated on 19 February 2024.

Results
Twenty-four studies were identified and confirmed that patients with dementia frequently resort to the ED near the end of life, frequently more than once in their last year of life. Eight studies directly addressed palliative care needs, suggesting significant rates of palliative care needs among patients with dementia and in comparison, to other oncological or non-oncological conditions. Infections and neuropsychiatric symptoms were the main reasons of admission to the ED. Access to palliative care was confirmed to be low.

Significance of results
This scoping review indicates that patients with dementia frequently resource to the ED in their last year of life with unmet palliative care needs. Although scarce access to palliative care and the existence of important barriers in the ED, palliative care intervention in this setting can be seen as an opportunity to attend palliative care needs and referral to palliative care services.
Ray tracing simulation and experimental validation for millimeter-wave massive MIMO systems
Authors: Di Jingyun , Yuan Zhiqiang , Lyv Yejian , Tan Rong , Fan Wei 
Published: January 2025

Abstract
Accurate channel characterization is extremely helpful in channel estimation, channel coding, and many other parts of communication system design and can effectively reduce overhead. Ray tracing (RT) shows accurate channel reconstruction for specific maps, but the multipath propagation in indoor scenes is far more complex than in outdoor scenes leading to a challenge for RT. This work presents and validates an RT tool for a massive multiple-input multiple-output (MIMO) system in the millimeter-wave frequency bands with the associated channel beamforming algorithm and provides ideas for channel estimation algorithm in subsequent MIMO systems. The impact of the order of interactions, e.g. reflections and diffractions on the channel impulse response reconstruction are analyzed in the RT simulation. The comparison between RT simulated and measured results shows a reasonable level of agreement. The presented RT tool that can provide complete and accurate channel information is of high value for the design of reliable communication systems.
Managed freedom in precarious times: Maintaining academic freedom in transitional Hong Kong
Authors: Fu Hualing 
Published: January 2025

Abstract
This article examines the status of academic freedom in Hong Kong in light of the increasing securitization of higher education since the implementation of the National Security Law (NSL) in 2020. It provides an analytical framework to comprehend the changing landscape of academic freedom in Hong Kong, highlighting the impact of the NSL and the conflict between the necessity of political control on securitized campuses and the demand for international, free, and high-quality universities to make Hong Kong a global hub for higher education. The article concludes by asserting that the NSL has reshaped and will continue to impact academic freedom and university autonomy concerning core security issues, but there is still a possibility to establish a defendable space for genuine academic freedom in classrooms.
Ceres: Organic‐Rich Sites of Exogenic Origin?
Authors: Sarkar R. , Nathues A. , Hoffmann M. , Cloutis E. , Mengel K. , Singh P. , Thangjam G. , Hernandez J. , Karunatillake S. , Coutelier M. 
Published: January 2025

AbstractCeres, the largest object in the asteroid belt, is the only potential ocean world in the inner Solar System. Previous studies identified deposits of aliphatic organics in and around the Ernutet crater, and at small locations at Inamahari and Urvara craters. The origin of organics, either endogenic or exogenic, in these fresh exposures is still under debate. This study addresses the origin of the organics by analyzing their global distribution and geologic context. Our first step involved a global search for organic‐rich sites that might have escaped previous detections. We achieved this by using a deep neural network, utilizing spectral redness in the Dawn's Framing Camera multispectral data to identify potential organic‐rich sites. The identified sites were further studied by using IR spectrometer data to infer the compositions of materials showing spectral redness. Of the newly identified red‐sloped sites, only two can be considered certain to be organic‐rich. We also identified sites with spectral redness, but without any signature of organics in their infrared spectra. These sites could be attributed to the aqueous alteration of magnetite into ferric‐iron bearing phases. At Ernutet, Inamahari, and Urvara, the organic‐rich material is confined to the near surface only. Additionally, the absence of tectonic/volcanic features at these sites makes an endogenic origin questionable. The global rarity of detectable organics also supports this assessment. Consequently, we suggest that organics at these sites were originally delivered by low‐velocity, organic‐rich impactor(s) from the main belt and subsequently excavated, rather than originating from endogenous processes.
Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer
Authors: Tseng Yen-Han , Tran Trieu Thi My , Tsai Chang Jinghua , Huang Yu-Tang , Nguyen Anh Thuc , Chang Ian Yi‑Feng , Chen Yi-Tung , Hsieh Hao-Wen , Juang Yue-Li , Chang Peter Mu-Hsin , Huang Tzu-Yi , Chang Ying-Chih , Chen Yuh-Min , Liu Hsuan , Huang Chi-Ying F. 
Published: January 2025

Abstract

TP53 mutations are recognized to correlate with a worse prognosis in individuals with non-small cell lung cancer (NSCLC). There exists an immediate necessity to pinpoint selective treatment for patients carrying TP53 mutations. Potential drugs were identified by comparing drug sensitivity differences, represented by the half-maximal inhibitory concentration (IC50), between TP53 mutant and wild-type NSCLC cell lines using database analysis. In addition, clinical data from NSCLC patients were collected to evaluate both their TP53 status and their response to gemcitabine, thereby facilitating further validation. Subsequently, NSCLC cell lines with different TP53 status (A549 and H1299) were subjected to gemcitabine treatment to investigate the association between TP53 mutations and gemcitabine response. According to the dataset, NSCLC cell lines carrying TP53 mutations displayed heightened sensitivity to gemcitabine. From a clinical standpoint, patients exhibiting TP53 hotspot mutations demonstrated prolonged overall survival upon gemcitabine treatment. In vitro, overexpressing various hotspot TP53 mutations significantly sensitized H1299 cells to gemcitabine. Moreover, the knockdown of TP53 in A549 cells notably augmented sensitivity to gemcitabine treatment, as evidenced by cell viability and reproductive cell death assays. Conversely, the overexpression of wild-type TP53 in H1299 cells led to an increased resistance against gemcitabine. Gemcitabine is a treatment option for patients with non-small cell lung cancer (NSCLC) who carry TP53 hotspot mutations. This potential effectiveness might arise from its ability to disrupt DNA damage repair processes, leading to G2/M phase cell cycle arrest or an augmentation of mitotic abnormalities, eventually cause cell death. As a result, when planning treatment strategies for NSCLC patients possessing TP53 hotspot mutations, gemcitabine should be considered to incorporate into the indication.
Nutrition and Hypertension Researches in 2023: focus on salt intake and blood pressure
Authors: Matsumoto Chisa 
Published: January 2025

Abstract
Hypertension is a major global health issue that contributes significantly to cardiovascular morbidity and mortality. The management and prevention of hypertension often involve nutritional and dietary modifications, which are considered effective non-pharmacological strategies. In 2023, the Hypertension Research published several papers highlighting nutrition and hypertension. In addition, multiple studies published in leading journals explored the relationship between salt intake and blood pressure (BP) in 2023. In this mini-review, we summarize the key findings of nutritional studies published in the Hypertension Research in 2023. This mini-review also highlights significant findings from the latest research on salt intake and its impact on BP. The new findings from nutritional studies will provide deeper insights on planning dietary strategies for the management of hypertension.
Splicing accuracy varies across human introns, tissues, age and disease
Authors: García-Ruiz S. , Zhang D. , Gustavsson E. K. , Rocamora-Perez G. , Grant-Peters M. , Fairbrother-Browne A. , Reynolds R. H. , Brenton J. W. , Gil-Martínez A. L. , Chen Z. , Rio D. C. , Botia J. A. , Guelfi S. , Collado-Torres L. , Ryten M. 
Published: January 2025

Abstract
Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigate splicing accuracy using RNA-sequencing data from >14k control samples and 40 human body sites, focusing on split reads partially mapping to known transcripts in annotation. We show that splicing inaccuracies occur at different rates across introns and tissues and are affected by the abundance of core components of the spliceosome assembly and its regulators. We find that age is positively correlated with a global decline in splicing fidelity, mostly affecting genes implicated in neurodegenerative diseases. We find support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease as compared to neurologically normal individuals. In this work, we provide an in-depth characterisation of splicing accuracy, with implications for our understanding of the role of inaccuracies in ageing and neurodegenerative disorders.
NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control
Authors: Imai Shin-ichiro 
Published: January 2025

Abstract
Over the past five years, systemic NAD+ (nicotinamide adenine dinucleotide) decline has been accepted to be a key driving force of aging in the field of aging research. The original version of the NAD World concept was proposed in 2009, providing an integrated view of the NAD+-centric, systemic regulatory network for mammalian aging and longevity control. The reformulated version of the concept, the NAD World 2.0, was then proposed in 2016, emphasizing the importance of the inter-tissue communications between the hypothalamus and peripheral tissues including adipose tissue and skeletal muscle. There has been significant progress in our understanding of the importance of nicotinamide mononucleotide (NMN), a key NAD+ intermediate, and nicotinamide phosphoribosyltransferase (NAMPT), particularly extracellular NAMPT (eNAMPT). With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, is now proposed, featuring multi-layered feedback loops mediated by NMN and eNAMPT for mammalian aging and longevity control.
Codeveloping a community-based, peer-led psychosocial support intervention to reduce stigma and depression among people with tuberculosis and their households in Indonesia: a mixed-methods participatory action study
Authors: Fuady Ahmad , Anindhita Mariska , Hanifah Matsna , Putri Arieska Malia Novia , Karnasih Artasya , Agiananda Feranindhya , Yani Finny Fitry , Haya Marinda Asiah Nuril , Pakasi Trevino Aristaskus , Wingfield Tom 
Published: January 2025

Abstract
Evidence relating to peer support and community-based psychological and social (psychosocial) interventions to reduce stigma and depression among people with tuberculosis (TB) and their households is limited. This study aimed to engage with multisectoral stakeholders in Indonesia to co-develop a peer-led, community-based psychosocial intervention that is replicable, acceptable, and sustainable. We used a participatory action design and engaged key national, multisectoral stakeholders to ensure that the intervention co-design was relevant and appropriate to the TB health system and the sociocultural context of Indonesia. The co-design of the intervention evolved through four phases: (1) a scoping review to identify a long list of potential TB stigma reduction interventions; (2) a modified Delphi survey to define a shortlist of the potential interventions; (3) a national multisectoral participatory workshop to identify and pre-finalize the most viable elements of psychosocial support to distill into a single multi-faceted intervention; and (4) finalization of the intervention activities. The scoping review identified 12 potential intervention activities. These were then reduced to a shortlist of six potential intervention activities through a modified Delphi Survey completed by 22 multisectoral stakeholder representatives. At the national participatory workshop, the suitability, acceptability, and feasibility of the six potential intervention activities were discussed by the key stakeholders, and consensus reached on the final four activities to be integrated into the psychosocial support intervention. These activities consisted of: individual psychological assessment and counselling; monthly peer-led group counselling; peer-led individual support; and community-based TB Talks. In Indonesia, meaningful participation of multisectoral stakeholders facilitated co-design of a community-based, peer-led intervention to reduce TB stigma and depression amongst people with TB and their households. The intervention was considered to be locally appropriate and viable, and is being implemented and evaluated as part of the TB-CAPS intervention study.
A genome-wide atlas of human cell morphology
Authors: Ramezani Meraj , Weisbart Erin , Bauman Julia , Singh Avtar , Yong John , Lozada Maria , Way Gregory P. , Kavari Sanam L. , Diaz Celeste , Leardini Eddy , Jetley Gunjan , Pagnotta Jenlu , Haghighi Marzieh , Batista Thiago M. , Pérez-Schindler Joaquín , Claussnitzer Melina , Singh Shantanu , Cimini Beth A. , Blainey Paul C. , Carpenter Anne E. , Jan Calvin H. , Neal James T. 
Published: January 2025

Abstract
A key challenge of the modern genomics era is developing empirical data-driven representations of gene function. Here we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-wide genotype–phenotype maps comprising CRISPR–Cas9-based knockouts of >20,000 genes in >30 million cells. Our optical pooled cell profiling platform (PERISCOPE) combines a destainable high-dimensional phenotyping panel (based on Cell Painting) with optical sequencing of molecular barcodes and a scalable open-source analysis pipeline to facilitate massively parallel screening of pooled perturbation libraries. This perturbation atlas comprises high-dimensional phenotypic profiles of individual cells with sufficient resolution to cluster thousands of human genes, reconstruct known pathways and protein–protein interaction networks, interrogate subcellular processes and identify culture media-specific responses. Using this atlas, we identify the poorly characterized disease-associated TMEM251/LYSET as a Golgi-resident transmembrane protein essential for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. In sum, this perturbation atlas and screening platform represents a rich and accessible resource for connecting genes to cellular functions at scale.
Effects of copper/graphene oxide core-shell nanoparticles on Rhipicephalus ticks and their detoxification enzymes
Authors: Senbill Haytham , Gangan Amr , Saeed Ahmed M. , Gad Mohammed E. , Zeb Jehan , Fahmy Alaa 
Published: January 2025

Abstract
Nanopesticides have been recently introduced as novel pesticides to overcome the drawbacks of using traditional synthetic pesticides. The present study evaluated the acaricidal activity of Copper/Graphene oxide core-shell nanoparticles against two tick species, Rhipicephalus rutilus and Rhipicephalus turanicus. The Copper/Graphene oxide core-shell nanoparticles were synthetized through the solution plasma (SP) method under different conditions. The nanoparticles synthesized at 180 W and 45 min were highly toxic to Rh. rutilus and Rh. turanicus, with 50% lethal concentration (LC50) values of 248.1 and 195.7 mg ml−1, respectively, followed by those which were synthesized at 120 W/30 mins (LC50 = 581.5 and 526.5 mg ml−1), 120 W/15 mins (LC50 = 606.9 and 686.7 mg ml−1), and 100/45 mins (LC50 = 792.9 and 710.7 mg ml−1), after 24 h of application. The enzyme assays revealed that 180 W/45 min treatment significantly inhibited the activity of acetylcholinesterase (115 ± 0.81 and 123 ± 0.33 U/ mg protein/min) and superoxide dismutase (290 ± 0.18 and 310 ± 0.92 U/ mg protein/min) in Rh. rutilus and Rh. turanicus, respectively, as compared with the negative control. The results also revealed a significantly increased catalase activity (895 ± 0.37 and 870 ± 0.31 U/ mg protein/min) in Rh. rutilus and Rh. turanicus, respectively. The above results indicated that Copper/Graphene oxide core-shell nanoparticles could be a promising alternatives for the management of ticks.
Unveiling the potential of Aspergillus terreus SJP02 for zinc remediation and its driving mechanism
Authors: Shobham  , Bhanot Vishalakshi , Mamta  , Verma Sanjay Kumar , Gupta Suresh , Panwar Jitendra 
Published: January 2025

Abstract
In present study, 15 morphologically different fungi isolated from rhizopheric soils of an industrial area were screened for their Zn2+ removal efficiency from aqueous solution. Isolate depicting highest potential was molecularly identified as Aspergillus terreus SJP02. Effect of various process parameters viz. biosorbent dose, contact time, temperature, agitation rate, pH and initial Zn2+ concentration on the fungal sorption capacity were studied. The biosorbent exhibited maximum Zn2+ sorption capacity of 10.7 ± 0.2 mg g− 1 in 60 min. Desorption studies showed 71.46% Zn2+ recovery rate in 120 min with 0.01 N HNO3, indicating efficient metal recovery for reuse and subsequent reutilization of spent mycosorbents. Acid digestion study suggested adsorption being the primary mechanism accounting for 87% Zn2+removal. It was further confirmed by the FE-SEM and EDX analysis. FTIR analysis suggested involvement of amino, hydroxyl, carbonyl, and phosphate functional groups of fungal cell wall in adsorption. The experimental results were in accordance with the tested isotherm and kinetic models, and suggested the role of physical adsorption for Zn2+ removal. Noteworthy, the present study showed better sorption capacity in considerably shorter equilibration time compared to previous reports and advocate potential utilization of A. terreus SJP02 for bioremediation of Zn2+ contaminated wastewater at industrial scale.
Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua
Authors: Hu Bo , Deng Yuping , Lu Tao , Ren Miaomiao , Liu Kuitun , Rao Cong , Guo Hailiang , Su Jianya 
Published: January 2025

Abstract
Synthetic insecticides have been widely used for the prevention and control of disease vectors and agricultural pests. However, frequent uses of insecticides have resulted in the development of insecticide resistance in these insect pests. The resistance adversely affects the efficacy of insecticides, and seriously reduces the lifespan of insecticides. Therefore, resistance management requires new strategies to suppress insecticide resistance. Here, we confirm that CncC/Maf are the key regulators of various detoxification genes involved in insecticide resistance in Spodoptera exigua. Then, we develop a cell screening platform to identify the natural compound inhibitors of CncC/Maf and determine that sofalcone can act as a CncC/Maf inhibitor in vitro and in vivo. Bioassay results showed that sofalcone significantly enhanced the toxicity (more than 3-fold) of chlorpyrifos and lambda-cyhalothrin against S. exigua larvae. Finally, we demonstrate that sofalcone can greatly improve the susceptibility of S. exigua larvae to insecticides by inhibiting the activity of the ROS/CncC-dependent detoxifying enzymes and downregulating the expression levels of detoxification genes. CncC/Maf inhibitors can be used as broad-spectrum synergists to overcome insecticide resistance in pest populations. Altogether, our results demonstrate that reduced expression of detoxification genes resulting from suppression of transcriptional regulation of these genes contributes to controlling insecticide resistance, which provides a very novel and high-efficiency green resistance management strategy.