bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' views and experiences of the home mathematics environment: A cross‐country study
Authors: Cahoon Abbie , Campver Yanet , Estévez Nancy , Jiménez Lira Carolina , Paz García Daniela Susana , Benavides Pando Elia Veronica , Simms Victoria 
Published: February 2024

AbstractThe purpose of the current study was to qualitatively explore the home mathematical environment across two regions in two different countries (i.e., Cuba and Mexico), replicating a qualitative study previously conducted in Northern Ireland (NI), United Kingdom (Cahoon et al., 2017). Semi‐structured interviews with parents/caregivers of children (3‐ to 5‐year‐olds) in both Mexico (n = 13) and Cuba (n = 40) were completed to investigate their views, experiences and attitudes towards the home mathematical environment. Thematic analysis was used to explore themes relevant to the home mathematical environment. Three consistent themes were found in the Mexican and Cuban data: Numeracy Environment Structure, Expectations and Attitudes and Views of Technology. Two unique themes were found in the Mexico data: Interactions Related to Reading or Mathematics, and Child's Attitudes in Relation to Mathematics. One unique theme was found in the Cuban interviews: Interactions for Learning. Although diverse themes were identified, consistencies were also observed. This suggests that some home numeracy practices may be universal in nature. This research increases the understanding of human development in context.
Neoadjuvant chemo‐ or chemo‐radiation‐therapy of pancreatic ductal adenocarcinoma differentially shift ECM composition, complement activation, energy metabolism and ribosomal proteins of the residual tumor mass
Authors: Stillger Maren N. , Kurowski Konrad , Bronsert Peter , Brombacher Eva , Kreutz Clemens , Werner Martin , Tang Laura , Timme‐Bronsert Sylvia , Schilling Oliver 
Published: February 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, often diagnosed at stages that dis‐qualify for surgical resection. Neoadjuvant therapies offer potential tumor regression and improved resectability. Although features of the tumor biology (e.g., molecular markers) may guide adjuvant therapy, biological alterations after neoadjuvant therapy remain largely unexplored. We performed mass spectrometry to characterize the proteomes of 67 PDAC resection specimens of patients who received either neoadjuvant chemo (NCT) or chemo‐radiation (NCRT) therapy. We employed data‐independent acquisition (DIA), yielding a proteome coverage in excess of 3500 proteins. Moreover, we successfully integrated two publicly available proteome datasets of treatment‐naïve PDAC to unravel proteome alterations in response to neoadjuvant therapy, highlighting the feasibility of this approach. We found highly distinguishable proteome profiles. Treatment‐naïve PDAC was characterized by enrichment of immunoglobulins, complement and extracellular matrix (ECM) proteins. Post‐NCT and post‐NCRT PDAC presented high abundance of ribosomal and metabolic proteins as compared to treatment‐naïve PDAC. Further analyses on patient survival and protein expression identified treatment‐specific prognostic candidates. We present the first proteomic characterization of the residual PDAC mass after NCT and NCRT, and potential protein candidate markers associated with overall survival. We conclude that residual PDAC exhibits fundamentally different proteome profiles as compared to treatment‐naïve PDAC, influenced by the type of neoadjuvant treatment. These findings may impact adjuvant or targeted therapy options.
A diagnostically challenging case of inflammatory myofibroblastic tumor primary to the peritoneum
Authors: Karibe Jurii , Teranishi Jun‐ichi , Kawahara Takashi , Noguchi Takeaki , Takeshima Teppei , Osaka Kimito , Kumagai Eita , Sawazumi Tomoe , Fujii Satoshi , Uemura Hiroji 
Published: February 2024

IntroductionInflammatory myofibroblastic tumors are difficult to diagnose because of the lack of specific indicators. We describe a diagnostically challenging case of an inflammatory myofibroblastic tumor primary to the peritoneum.Case presentationThe patient was a 25‐year‐old male who presented at our hospital with lower abdominal pain. Computed tomography revealed a mass lesion 80 mm in diameter just above the bladder. This was suspected to be a bleeding tumor of the urachus. Since malignancy could not be ruled out, surgery was planned. This revealed a fragile tumor arising from the peritoneum. Following its removal, the tumor was diagnosed by histopathological analysis as an inflammatory myofibroblastic tumor.ConclusionWe describe a case of inflammatory myofibroblastic tumor primary to the peritoneum diagnosed by histopathology. Inflammatory myofibroblastic tumor should be considered in the differential diagnosis of abdominal wall and anterior bladder tumors.
Adolescents' relationships with parents and romantic partners in eight countries
Authors: Gorla Laura , Rothenberg W. Andrew , Lansford Jennifer E. , Bacchini Dario , Bornstein Marc H. , Chang Lei , Deater‐Deckard Kirby , Di Giunta Laura , Dodge Kenneth A. , Gurdal Sevtap , Junla Daranee , Liu Qin , Long Qian , Oburu Paul , Pastorelli Concetta , Skinner Ann T. , Sorbring Emma , Steinberg Laurence , Tirado Liliana Maria Uribe , Yotanyamaneewong Saengduean , Alampay Liane P. , Al‐Hassan Suha M. 
Published: February 2024

AbstractIntroductionCreating romantic relationships characterized by high‐quality, satisfaction, few conflicts, and reasoning strategies to handle conflicts is an important developmental task for adolescents connected to the relational models they receive from their parents. This study examines how parent–adolescent conflicts, attachment, positive parenting, and communication are related to adolescents' romantic relationship quality, satisfaction, conflicts, and management.MethodWe interviewed 311 adolescents at two time points (females = 52%, ages 15 and 17) in eight countries (China, Colombia, Italy, Kenya, the Philippines, Sweden, Thailand, and the United States). Generalized and linear mixed models were run considering the participants' nesting within countries.ResultsAdolescents with negative conflicts with their parents reported low romantic relationship quality and satisfaction and high conflicts with their romantic partners. Adolescents experiencing an anxious attachment to their parents reported low romantic relationship quality, while adolescents with positive parenting showed high romantic relationship satisfaction. However, no association between parent–adolescent relationships and conflict management skills involving reasoning with the partner was found. No associations of parent–adolescent communication with romantic relationship dimensions emerged, nor was there any effect of the country on romantic relationship quality or satisfaction.ConclusionThese results stress the relevance of parent–adolescent conflicts and attachment as factors connected to how adolescents experience romantic relationships.
The role of second trimester uterine artery Doppler in predicting obstetric and neonatal outcomes in abnormal first trimester maternal serum pregnancy‐associated plasma protein‐A and free β‐human chorionic gonadotropin values
Authors: Dal Yusuf , Akkuş Fatih , Karagün Şebnem , Nessar Ahmet Zeki , Karaca Sefanur Gamze , Coşkun Ayhan 
Published: February 2024

AbstractAimThis study aims to determine whether second‐trimester uterine artery (UtA) Doppler combined with first‐trimester abnormal pregnancy‐associated plasma protein‐A (PAPP‐A) and β‐human chorionic gonadotropin (β‐Hcg) levels predicts adverse obstetric and neonatal outcomes.Materials and MethodsThis study of 289 pregnant women included 196 with normal PAPP‐A and free β‐HCG values (control group) and 93 with abnormal values (study group) in the first‐trimester screening test. Second‐trimester UtA Doppler sonography was done in these pregnancies. The perinatal prediction and screening potential of UtA Doppler pulsatility index (PI) parameters were examined in the study group.ResultsUtA PI >95 percentile increased birth before the 37th week by 4.46 times, birth before the 34th week by 7.44 times, preeclampsia risk by 3.25 times, fetal growth restriction (FGR) risk by 4.89 times, and neonatal intensive care unit (NICU) admission rates by 3.66 times in the study group (p < 0.05 for all). UtA PI >95 percentile had 49.2% sensitivity and 82.1% specificity for birth before 37 weeks. For birth before 34 weeks, sensitivity was 80.0% and specificity 65.0%. FGR has 70.5% sensitivity and 67.1% specificity. Screening for preeclampsia has 66.6% sensitivity and 61.9% specificity.ConclusionAdding UtA Doppler in the second trimester to pregnancies with abnormal PAPP‐A and/or free β‐Hcg values in the first trimester may be a useful screening method for adverse outcomes.
Evaluating the biological (antidiabetic) potential of TEM, FTIR, XRD, and UV‐spectra observed berberis lyceum conjugated silver nanoparticles
Authors: Mughal Tafail Akbar , Ali Shaukat , Mumtaz Shumaila , Summer Muhammad , Saleem Muhammad Zubair , Hassan Ali , Hameed Muhammad Usman 
Published: February 2024

AbstractDiabetes is a life‐threatening disease that affects different parts of the body including the liver, kidney, and pancreas. The core root of diabetes is mainly linked to oxidative stress produced by reactive oxygen species (ROS). Berberis lyceum Royle (BLR) is the source of natural products. It comprises numerous bioactive compounds having antioxidant activities. In the current investigation, silver nanoparticles from BLR root extract were synthesized, characterized, and assessed for antidiabetic potential. UV spectrophotometry, Transmission electron microscopy (TEM), Fourier transform infra‐red spectroscopy (FTIR), and x‐ray diffraction (XRD) were applied for the characterization of NPs. It was evident from the morphological studies that the synthesized NPs were spherical and the average size was 11.02 nm. Results revealed that BLR‐AgNPs showed higher radical scavenging activity as compared to BLR extract. Moreover, BLR‐AgNPs displayed superior in vivo and in vitro antidiabetic activity in comparison to BLR extract. Glucose level (116.5 ± 5.1 mg/dL), liver function test (ALAT: 54.038 ± 6.2 IU/L; ASAT: 104.42 ± 13.9 IU/L; ALP: 192.6 ± 2.4 IU/L; bilirubin: 1.434 ± 0.14 mg/dL; total protein: 5.14 ± 0.24 mg/dL), renal function test (urea: 39.6 ± 0.63 mg/dL; uric acid: 21.4 ± 0.94 mg/dL; creatinine: 0.798 ± 0.03 mg/dL; albumin: 4.14 ± 0.2 mg/dL), lipid profile level (cholesterol: 101.62 ± 3 mg/dL; triglyceride: 110.42 ± 7 mg/dL; HDL‐C: 29.7 ± 3 mg/dL; LDL‐C: 47.056 ± 1 mg/dL; VLDL‐C: 22.0 ± 1.3 mg/dL) and hematology (WBCs: 3.82 ± 0.24 103 /μL; RBCs: 4.78 ± 0.42 106 /μL; Hb: 12.6 ± 1.0 g/dL; Hematocrit: 39.4 ± 3.7%; MCV: 65.8 ± 3 fL; platelets: 312 ± 22.4; neutrophils: 34.8 ± 1.87; eosinophils: 3.08 ± 0.43; monocytes: 3.08 ± 0.28; lymphocytes: 75.6 ± 3.77) confirmed the significant antidiabetic potential of BLR‐AgNPs. Histopathological examination authenticated that BLR‐AgNPs caused a significant revival in the morphology of the liver, kidney, and pancreas. Hence, findings of the study suggested the BLR‐AgNPs as a potent antidiabetic agent and could be an appropriate nanomedicine to prevent diabetes in future.Research Highlights
Berberis lyceum extract as a reducing, capping, and stabilization agent for the BLR‐AgNPs synthesis
Evaluation of α‐amylase inhibition, antioxidant, and α‐glucosidase inhibition potential
Thorough characterization using Fourier transform infrared spectroscopy, Transmission electron microscopy, x‐ray diffraction, and UV–VIS spectrophotometer, which is 1st of its kind
In‐vivo antidiabetic activity evaluation through multiple biomarkers
Differentiation of large extracellular vesicles in oral fluid: Combined protocol of small force centrifugation and sedimentation pattern analysis
Authors: Kawano Takamasa , Okamura Kohji , Shinchi Hiroki , Ueda Koji , Nomura Takeshi , Shiba Kiyotaka 
Published: February 2024

AbstractExtracellular vesicles (EVs) in biofluids are highly heterogeneous entities in terms of their origins and physicochemical properties. Considering the application of EVs in diagnostic and therapeutic fields, it is of extreme importance to establish differentiating methods by which focused EV subclasses are operationally defined. Several differentiation protocols have been proposed; however, they have mainly focused on smaller types of EVs, and the heterogeneous nature of large EVs has not yet been fully explored. In this report, to classify large EVs into subgroups based on their physicochemical properties, we have developed a protocol, named EV differentiation by sedimentation patterns (ESP), in which entities in the crude large EV fraction are first moved through a density gradient of iodixanol with small centrifugation forces, and then the migration patterns of molecules through the gradients are analysed using a non‐hierarchical data clustering algorithm. Based on this method, proteins in the large EV fractions of oral fluids clustered into three groups: proteins shared with small EV cargos and enriched in immuno‐related proteins (Group 1), proteins involved in energy metabolism and protein synthesis (Group 2), and proteins required for vesicle trafficking (Group 3). These observations indicate that the physiochemical properties of EVs, which are defined through low‐speed gradient centrifugation, are well associated with their functions within cells. This protocol enables the detailed subclassification of EV populations that are difficult to differentiate using conventional separation methods.
Beta‐Catenin‐Mutated Hepatocellular Adenomas at Hepatobiliary Phase MRI: A Systematic Review and Meta‐Analysis
Authors: Shen Luyao , Altmayer Stephan , Tse Justin R. 
Published: February 2024

BackgroundBeta‐catenin‐mutated hepatocellular adenomas (β‐HCAs) can appear iso‐ to hyperintense at the hepatobiliary phase (HBP) at magnetic resonance imaging (MRI). Given the relatively lower prevalence of β‐HCAs, prior studies had limited power to show statistically significant differences in the HBP signal intensity between different subtypes.PurposeTo assess the diagnostic performance of HBP MRI to discriminate β‐HCA from other subtypes.Study TypeSystemic review and meta‐analysis.PopulationTen original studies were included, yielding 266 patients with 397 HCAs (9%, 36/397 β‐HCAs and 91%, 361/397 non‐β‐HCAs).Field Strength/Sequence1.5 T and 3.0 T, HBP.AssessmentPubMed, Web of Science, and Embase databases were searched from January 1, 2000, to August 31, 2023, for all articles reporting HBP signal intensity in patients with histopathologically proven HCA subtypes. QUADAS‐2 was used to assess risk of bias and concerns regarding applicability.Statistical TestsUnivariate random‐effects model was used to calculate pooled estimates. Heterogeneity estimates were assessed with I2 heterogeneity index. Meta‐regression (mixed‐effect model) was used to test for differences in the prevalence of HBP signal between HCA groups. The threshold for statistical significance was set at P < 0.05.ResultsHBP iso‐ to hyperintensity was associated with β‐HCAs (pooled prevalence was 72.3% in β‐HCAs and 6.3% in non‐β‐HCAs). Pooled sensitivity and specificity were 72.3% (95% confidence interval 54.1–85.3) and 93.7% (93.8–97.7), respectively. Specificity had substantial heterogeneity with I2 of 83% due to one study, but not for sensitivity (I2 = 0). After excluding this study, pooled sensitivity and specificity were 77.4% (59.6–88.8) and 94.1% (88.9–96.9), with no substantial heterogeneity. One study had high risk of bias for patient selection and two studies were rated unclear for two domains.Data ConclusionIso‐ to hyperintensity at HBP MRI may help to distinguish β‐HCA subtype from other HCAs with high specificity. However, there was heterogeneity in the pooled estimates.Level of Evidence3Technical EfficacyStage 2
The impact of ABO blood types on humoral immunity responses and antibody persistency after different COVID‐19 vaccine regimens
Authors: Sadat Larijani Mona , Javadi Amir , Eskandari Seyed Ebrahim , Doroud Delaram , Ashrafian Fatemeh , Banifazl Mohammad , Khamesipour Ali , Bavand Anahita , Ramezani Amitis 
Published: February 2024

AbstractThis study evaluated the possible effects of blood types on coronavirus disease (COVID‐19) vaccine immunogenicity and antibody (Ab) persistency. Five different vaccinated groups against COVID‐19 were investigated at Pasteur Institute of Iran from April 2021 to December 2022. Anti‐Spike IgG and neutralizing Ab rise were tracked on Day 21 as well as the humoral immune persistency assessment 180 after booster shots. Late adverse events up to 6 months after the booster dose were collected. The results showed that blood type A, led to a significantly higher anti‐Spike Ab rise in AstraZeneca primed recipients in comparison with Sinopharm primed ones in heterologous regimens (p: 0.019). Furthermore, blood type O was a great co‐effector in homologous AstraZeneca recipients regarding neutralizing Ab rise (0.013). In addition, blood type O led to a better anti‐Spike Ab persistency in the Sinopharm homologous group whereas type A had the best effect on neutralizing Ab durability in the same vaccine group. What is more, Rh‐positive individuals in AstraZeneca + PastoCovac Plus group had a higher rate of anti‐Spike Ab rise (p = 0.001). Neutralizing Ab rise was also induced in AstraZeneca homologous and heterologous regimens of Rh‐positive individuals significantly higher than Sinopharm primed cases. The present study showed the potential impact of blood types A/O and Rh‐positive on a better humoral immune responses and Ab persistency. It is proposed that blood type A and Rh‐positive could increase the Ab rise in AstraZeneca vaccinated individuals. Moreover, blood type O might be a better co‐effector of anti‐Spike Ab persistency in Sinopharm recipients.
A Wandering Mind is Not Always a Creative Mind: How Thought Dynamics Explain the Relationship between Mind Wandering and Creativity
Authors: de Rooij Alwin , Atef Ali , Faber Myrthe 
Published: February 2024

ABSTRACTA wandering mind is not always a creative mind. Anecdotes about ideas spontaneously entering awareness during walks, showers, and other off‐task activities are plenty. The science behind it, however, is still inconclusive. Creativity might result from how thought context—whether thoughts are on‐task or off‐task—relates to thought dynamics—how thoughts unfold. To explore this, study 1 (n = 85) surveyed creative professionals about a single idea they had earlier in the day. The spontaneity of thoughts positively correlated with self‐reported creativity, whereas off‐task thoughts or doing something else did not. Study 2 (n = 180) replicated these findings in a student sample during an idea generation task and added that free movement of thoughts also correlates with self‐reported originality during idea generation. As indicated by expert ratings, no relationship of thought dynamics and thought context was found with population‐level creativity. Herewith, this study suggests that thought dynamics, rather than thought context, explain the often suggested relationship between mind wandering and creativity.
Supercritical extraction of betalains from the peel of different pitaya species
Authors: Lacerda Vander Rocha , Bastante Cristina Cejudo , Machado Noelia D. , Vieites Rogério Lopes , Casas Cardoso Lourdes , Mantell‐Serrano Casimiro 
Published: February 2024

AbstractBACKGROUNDPitaya is a fruit with high consumer acceptance and health benefits. Pitaya peel is a waste product with potential in the food industry, as an antioxidant enrichment and natural colouring. Therefore, there is an interest in recovering its constituents and searching for pitaya species with greater potential. This work aimed to obtain bioactive extracts from the dried peel of pitaya fruits of the species Selenicereus monacanthus (Lem.), S. costaricensis W. and S. undatus H. using supercritical fluids at different pressures (100, 250 and 400 bar) and ethanol–water 15% v/v or ethanol 100% as co‐solvents. The extraction yield, antioxidant activity, colour and total betalain content were evaluated.RESULTSThe extract obtained from S. monacanthus showed the highest extraction yield (49.6 g kg−1), followed by S. costaricensis (27.5 g kg−1) and S. undatus (17.7 g kg−1) at 400 bar and 35 °C using ethanol 15%, v/v. The antioxidant capacity was strongly influenced by pressure, favouring the obtaining of betalain‐rich extracts at higher pressures, especially in the species S. costaricensis (0.6 g kg−1) and S. monacanthus (0.3 g kg−1). To improve the extraction of S. undatus (the most cultivated species), the procedure of subsequential extractions was applied. This procedure considerably increased the extraction yield, antioxidant activity and total content of betalains. The use of ethanol 100% provided more bioactive fractions and achieved a good separation of betalains.CONCLUSIONThe supercritical extraction method can overcome the challenge of efficiently extracting compounds from pitaya peel, due to the presence of bioactive compounds of great polarity. © 2024 Society of Chemical Industry.
Early mobilisation after hip fracture surgery is associated with improved patient outcomes: A systematic review and meta‐analysis
Authors: Agarwal Nikhil , Feng Tony , Maclullich Alasdair , Duckworth Andrew , Clement Nicholas 
Published: February 2024

AbstractIntroductionThe aims of this systematic review and meta‐analysis were to determine if after hip fracture surgery (1) early mobilisation is associated with improved clinical outcomes, and if so (2) are benefits directly proportional to how soon after surgery the patient mobilises.MethodsA Preferred Reporting Items for Systematic Reviews and Meta‐Analyses systematic review was conducted using four databases to identify all studies that compared postoperative early mobilisation with delayed mobilisation, in patients after hip fracture surgery. The Critical Appraisal Skills Programme checklist was employed for critical appraisal and evaluation of all studies that met the inclusion criteria.ResultsA total of 13 studies, including 297,435 patients were identified, of which 235,275 patients were mobilised early and 62,160 were mobilised late. Six studies assessed 30‐day mortality, of which two also investigated 30‐day complication rates. Pooled meta‐analysis demonstrated that there were significantly lower 30‐day mortality rates (odds ratio [OR] 0.35, 95% confidence interval [CI] 0.31–0.41, p < 0.001) and complication rates (OR 0.43, 95% CI 0.36–0.51, p < 0.001) in patients mobilising early after hip fracture surgery. Five studies investigated length of stay (LOS) and meta‐analysis revealed no difference between groups (mean difference −0.57 days, 95% CI −1.89–0.74, p = 0.39).ConclusionEarly mobilisation in hip fracture patients is associated with a reduction in 30‐day mortality and complication rates compared to delayed mobilisation, but no difference in LOS. These findings illustrate that early mobilisation is associated with superior post operative outcomes. However, a direct casual effect remains to be demonstrated, and further work on the factors underlying delayed mobilisation is required.