bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent-Adult Child Relationships and Repartnering After Gray Divorce
Authors: Brown Susan L , Lin I-Fen , Marino Francesca A , Mellencamp Kagan A 
Published: January 2025

Abstract

Objectives
The rise in gray divorce has catalyzed repartnering in later life. However, the antecedents of older adult repartnering remain poorly understood, particularly the potential role of adult children. A form of ambiguous loss, marital disruption often leads to family boundary ambiguity, thereby weakening family ties. We investigated whether co-residence and proximity of, frequent contact with, and downward transfers to adult children were negatively associated with repartnering after gray divorce.

Methods
Data from the 1998-2018 Health and Retirement Study were used to estimate discrete-time event history models using logistic regression to predict repartnering after gray divorce among parents of adult children (N = 1,359).

Results
As expected, adult child co-residence as well as having a child who lived nearby and had frequent contact diminished the likelihood of repartnering. Parents whose children either did not live nearby or were nearby but did not have frequent contact were more likely to repartner than those with children nearby and in frequent contact or co-residing, signaling that both proximity and frequency of contact are related to repartnering. Additionally, the provision of financial support to adult children was associated with a lower risk of repartnering.

Discussion
Relationships with adult children shape parental repartnering behaviors. Echoing the concept of boundary ambiguity, our findings indicate that stronger family ties, as signaled by child co-residence or proximity and frequent contact as well as economic provision, tend to deter repartnering. These findings also indicate that absent strong family ties, older adults are more likely to form a new union.
Development and Validation of the Internalized Care Stigma Scale (ICSS): Measuring care stigma aimed at informal care for older adults in Germany
Authors: Zwar Larissa , König Hans-Helmut , Delfin Emily , Hajek André 
Published: January 2025

Abstract

Background and Objectives
In this study we developed and validated the Internalized Caregiver Stigma Scale (ICSS) to measure internalized stigma targeting informal care for older adults (≥60 years) in Germany.

Research Design and Methods
The ICSS scale was developed in the Attitudes Towards Informal Caregivers (ATTIC) project based on stigma theories and (cognitive) pretesting with informal caregivers. Informal long-term caregivers (aged ≥40 years; n=433) of older relatives (aged ≥60 years) were quota-sampled from the online panel GapFish in December 2023 (twice as many female and middle-aged (aged 40-64 years) caregivers than male and younger (18-39 years) or older adults (65+ years) were included in the sample). Caregiver identification and the Social Impact Scale were used for validation of the newly developed measure. Factor structure, reliability and concurrent validity were tested.

Results
A correlated two-factor model with excellent goodness of fit criteria and good to excellent internal consistency of the factors and the total scale was confirmed for the ICSS. The negative ICSS subscale correlated highly, and the positive ICSS subscale correlated weakly, with the care-specific Social Impact Scale. Both ICSS subscales were weakly correlated with caregiver identification. Both aspects of self-stigma showed significant associations with sociodemographic and care-specific factors in the regression models.

Discussion and Implications
The ICSS is the first scale measuring internalized stigma targeting informal care for older adults directly and shows excellent psychometric criteria. It provides the necessary tool for a new approach to analyze the complex psychosocial mechanisms in this highly relevant care context.
Epigenetic modification brings new opportunities for gene capture by transposable elements in allopolyploid Brassica napus
Authors: Xiao Yafang , Li Mengdi , Wang Jianbo 
Published: January 2025

Abstract
Polyploids are widespread in plants and are important drivers for evolution and biodiversity. Allopolyploidy activates transposable elements (TEs) and causes genomic shock. Plant genomes can regulate gene expression by changing the epigenetic modification of TEs, but the mechanism for TEs to capture genes remains to be explored. Helitron TEs used the “peel-and-paste” mechanism to achieve gene capture. We identified 3,156 capture events and 326 donor genes of Helitron TEs in Brassica napus (AnAnCnCn). The donor genes captured by TEs were related to the number, length and location of their exons. The gene-capturing TEs carrying donor gene fragments were evenly distributed on the genome, and more than half of them were involved in the construction of pseudogenes, becoming the reserve force for polyploid evolution. Gene fragment copies enhanced information storage, providing opportunities for gene mutation and the formation of new genes. Simultaneously, the siRNAs targeting TEs may act on the donor genes due to siRNA crosstalk, and the gene methylation levels increased and the expression levels decreased. The genome sought a balance between sacrificing donor gene expression and silencing TEs, allowing TEs to hide in the genome. In addition, epigenetic modifications may temporarily relax the control of gene capture during allopolyploidization. Our study identified and characterized gene capture events in B. napus, analyzed the effects of DNA methylation and siRNA on gene capture events, and explored the regulation mechanism of gene expression by TEs epigenetic modification during allopolyploidization, which will contribute to understanding the formation and evolution mechanism of allopolyploidy.
Ethical considerations on surrogacy
Authors:   Writing Group on behalf of the ESHRE Ethics Committee, Shenfield Francoise , Tarlatzis Basil , Baccino Guiliana , Bounartzi Theofano , Frith Lucy , Pennings Guido , Provoost Veerle , Vermeulen Nathalie , Mertes Heidi 
Published: January 2025

Abstract
Surrogacy is the assisted reproductive technology (ART) practice in which a person becomes pregnant, carries, and delivers a child on behalf of another couple/person, who are the intended parent(s). Surrogacy is an especially complex practice as the interests of the intended parents, the gestational carrier, and the future child may differ. This paper considers ethical questions related to different forms of surrogacy. It concludes that non-commercial surrogacy is an acceptable method of assisted reproduction for specific indications. When using surrogacy to form a family, it is essential that there are measures to protect all parties, to guarantee well-considered decision-making, and to minimize risks. The current paper formulates recommendations to promote these measures. This paper is an update to the ESHRE Task Force Ethics and Law Paper 10: Surrogacy and replaces this paper.
Considerations for using sharks as ocean observing platforms
Authors: Wiernicki Caroline J , Curtis Tobey H , Block Barbara A , Shivji Mahmood S , Vaudo Jeremy J , Wetherbee Bradley M , Holland Kim N , Pinti Jérôme , Oliver Matthew J , Carlisle Aaron B 
Published: January 2025

Abstract
The combination of animal-borne telemetry and oceanographic sensor technologies creates an opportunity for marine animals to serve as ocean observing platforms (OOPs), carrying tags that record in situ oceanographic data as they naturally move. In this study, we create a blueprint of shark OOP species selection, quantifying and comparing the potential for species to transmit collected data, the environmental ranges various candidates are expected to encounter, and the oceanographic features they may be expected to resolve. Metrics of data satellite transmission probability, movement behaviors, and environmental sampling ranges are calculated combining historically collected satellite tag data for 11 shark species tagged in the Atlantic and Pacific Ocean basins. Species with the highest satellite data transmission potential include shortfin mako (Atlantic and Pacific) and blue (Pacific) sharks. These species also demonstrated overlap in time and length scales for area-restricted search-like movement behaviors with several mesoscale ocean features, including hurricanes and upwelling events. Additional comparisons of decorrelation time scales between theoretical shark versus glider sampling platforms suggest that shark OOPs have the ability to provide three times more uncorrelated water column temperature and conductivity profiles than gliders at 15% of the operational cost.
Path planning and optimization for transmission line barrier operations in complex terrain based on multimachine collaborative control
Authors: Zhu Dan , Gao Jianguo 
Published: January 2025

Abstract
To address the challenges of path planning for transmission line barrier operations in complex terrains, this paper proposes a solution based on multimachine collaborative control. A path-planning algorithm that integrates multiple classical algorithms and incorporates multiobjective optimization methods is constructed to handle the complexities of challenging terrains. Auction algorithm and genetic algorithm are adopted to achieve optimal load balance by dynamically adjusting task allocation. Simulation results show that the proposed method effectively enhances task execution efficiency, optimizes path planning, and reduces energy consumption in complex terrains and dynamic environments, while maintaining high-obstacle avoidance success rates and communication stability.
Research on the optimization of intelligent electricity billing consolidation and the expansion of refund services based on deep learning
Authors: Chen Ye , Wu Fan , Wang Yue , Shi Jingyan , Wang Kun , Zhang Bo 
Published: January 2025

Abstract
The rapidly expanding electrical sector urgently requires more effective strategies for electricity fee management. This article designs and implements an intelligent billing management system based on the service-oriented architecture. Additionally, this research proposes a predictive model based on deep learning that integrates a cascaded model utilizing particle swarm optimization, self-organizing maps, and bidirectional gated recurrent units algorithms to accurately forecast electricity revenue and refund scenarios. Experimental results demonstrate the superior accuracy and efficiency of this integrated model.
Neurourbanism and its influence on public outdoor spaces and mental health
Authors: Abed Ahmad , Qurnfulah Emad , Helmi Mansour , Alhubashi Haytham , Salem Wahid , Hafez Diyaa , Hegazy Ibrahim 
Published: January 2025

Abstract
Mental health challenges, including stress, anxiety, and depression, are increasingly prevalent in urban settings, often exacerbated by inadequate access to well-designed public outdoor spaces (POS). This study explores the relationship between POS and mental health outcomes in Al Madinah and Jeddah, Saudi Arabia, using a mixed-methods approach involving literature review, case studies, and public surveys. Findings reveal significant disparities in POS satisfaction, with Al Madinah exhibiting lower availability and accessibility. Despite better POS access in Jeddah, mental health challenges remain widespread across both cities. Recommendations emphasize integrating neurourbanism principles into urban planning to create inclusive, accessible, and restorative urban environments.
Bispecific T-Cell Engagers for the Recruitment of T cells in Solid Tumors: A Literature Review
Authors: Dewaele Laura , Fernandes Ricardo 
Published: January 2025

Abstract
In the past decade, T-cell based immunotherapies have grown to become some of the most promising treatments for cancer. Following the success of immune checkpoint inhibitors, other T-cell based therapies emerged including CAR-T cells and bispecific T-cell engagers (BiTEs). BiTEs have the unique ability to crosslink T cells and tumor cells independently of MHC restriction. They do not rely on TCR specificity or the CD4+/CD8+ costimulatory molecules, overcoming tumor MHC downregulation and low-affinity TCR binding. However, like many other immunotherapies, BiTEs have shown limited success beyond the treatment of hematological malignancies. BiTEs for the treatment of solid tumors still face challenges. Studies in gastrointestinal tumors have revealed Fc toxicity, short half-lives, and immunotoxicity, leading to Fc-silenced half-life extended BiTEs with humanized single-chain variable fragments. Studies in prostate tumors, lung tumors, and malignant gliomas have identified promising targets in PSMA, DLL3, and EGFRvIII, respectively, but also highlighted the problems of on-target off-tumor and BiTE-specific toxicities and inaccessible and immunosuppressive tumor microenvironments. Ongoing research to overcome these limitations remains an interesting field to follow, as BiTEs have the potential to be a powerful tool, especially when used in combination with other immunotherapies.
Antibody ligation of HLA class II induces YAP nuclear localization and formation of cytoplasmic YAP condensates in human endothelial cells
Authors: Lone Moien , Anwar Tarique , Sinnett-Smith James , Jin Yi-Ping , Reed Elaine F , Rozengurt Enrique 
Published: January 2025

Abstract
Antibody (Ab) crosslinking of HLA class II (HLA II) molecules on the surface of endothelial cells (ECs) triggers proliferative and prosurvival intracellular signaling, which are implicated in promoting chronic Ab-mediated rejection (cAMR). Despite the importance of cAMR in transplant medicine, the mechanisms involved remain incompletely understood. Here, we examined the regulation of yes-associated protein (YAP) nuclear cytoplasmic localization and phosphorylation in human ECs challenged with Abs that bind HLA II, which are strongly associated with cAMR. To examine changes in YAP localization in response to Ab-mediated engagement of HLA II, we used an adenoviral vector to express the class II transactivator or treatment with interferon γ. In unstimulated ECs expressing HLA II, YAP localized mainly in the cytoplasm. Stimulation with HLA II Ab (0.1–1 µg/mL) induced marked translocation of YAP to the nucleus. HLA II signaling triggered by high concentrations of HLA II Ab (1 µg/mL) also induced prominent YAP localization in cytoplasmic punctate structures that were disassembled by exposure to 1,6-hexanediol, suggesting that these structures are biomolecular condensates. Using multiple treatments, including stimulation with serum, thrombin or HLA I Ab and conditions (eg ECs plated at different densities) indicate that formation of YAP cytoplasmic puncta can be dissociated from YAP nuclear localization and phosphorylation at Ser127, a site in YAP targeted by the Hippo kinases LATS1/2. The results revealed that HLA II signaling regulates YAP subcellular distributions in ECs and demonstrate, for the first time, that HLA II Ab selectively stimulates YAP concentration in punctate structures.
Distinct Cytokine Patterns Identify Acute and Convalescent Myocardial Involvement After Coronavirus Disease 2019: A Multicohort Biomarker Study
Authors: Zidar David A , McComsey Grace A , Anthony Donald D , McDaniel John , Chan Timothy A , Al-Kindi Sadeer G 
Published: January 2025

Abstract
We sought to identify the immunobiologic underpinnings of cardiac involvement as a postacute sequela of coronavirus disease 2019 (COVID-19) by comparing acute and convalescent populations. For the latter, an integrated analysis of cytokine levels, cardiac magnetic resonance imaging, and cardiopulmonary exercise capacity was performed. Unlike acute cardiac injury, which was associated with heightened tumor necrosis factor alpha (TNF-α) but not interleukin 18 (IL-18), convalescent myocardial inflammation/edema correlated with IL-18 but not TNF-α. Thus, inflammation is not a monolith in relation to cardiac involvement in the setting of COVID-19. Instead, convalescent cardiac involvement may emerge from mechanisms distinct from acute injury, and appropriately targeted therapies may prevent postacute sequalae of COVID-19.
Death in a Foreign Land: Turkish Muslim Exiles and the Making of Theodicy
Authors: Shively Kim 
Published: January 2025

Abstract
This article explores how Turkish Muslim migrants associated with the Gülen movement in the United States confront questions relating to death and burial in a foreign land. Customarily, diasporic Turks opt to repatriate to the homeland for burial. The followers of Fethullah Gülen, however, cannot easily return home because they are accused of masterminding the 2016 coup attempt in Turkey. The Turkish government thus views the movement as traitorous and deserving punishment, such that the movement members fear returning to Turkey, even to be buried. To make sense of their situation—to create a theodicy—movement members have drawn on Islamic history, ethical requirements, and philosophical traditions to reevaluate the eschatological implications of burial in a foreign land. The experience of exile has compelled them to reevaluate sacred history and rethink the promise of ultimate redemption in ways that foreground and valorize their unexpected expulsion from the homeland.
Endplate Remodeling: a key indicator of cigarette smoke exposure-induced intervertebral disc degeneration in a male rat model
Authors: Kelley Joshua , Li Hui , Sun Yi , Ren Pengling , Chen Guanghua , Sun Shuchun , Zhao Jichao , Buchweitz Nathan , Kern Michael , Reitman Charles A , Townsend Danyelle M , Yao Hai , Wu Yongren 
Published: January 2025

Abstract
Recent clinical studies have established a strong association between cigarette smoking and degenerative disc disease. Both in vitro and in vivo research indicated that cigarette smoke disrupts cellular homeostasis in the intervertebral disc (IVD), leading to spatiotemporal remodeling of the extracellular matrix, with a notable reduction in solute diffusivity within the cartilage endplate (CEP). As the CEP serves as a critical mechanical barrier and solute diffusion pathway for the IVD, both roles can be compromised by pathological changes in the tissue. This underscores the need for a more comprehensive examination of endplate remodeling during IVD degeneration, particularly in the context of cigarette smoking and cessation. The objective of this study was to perform a quantitative analysis of the structure-material property relationship changes in the endplate at tissue and cellular levels to determine how endplate mineralization progresses during IVD degeneration in the context of cigarette smoke exposure and cessation, using our previously developed Sprague–Dawley rat model. Our results indicates that cigarette smoke exposure induced endplate remodeling is characterized by a higher CEP histological grade, increased aberrant CEP calcification level, and elevated bony endplate surface flatness score, all of which correlated with an accelerated chondrocyte cell life cycle. Smoke cessation alone was insufficient to reverse the mineralization progression in the endplate. Principal component analysis further identified alterations in endplate morphometry at the tissue level and disruptions in the chondrocyte life cycle at cellular level as key markers of degenerative remodeling. These findings establish endplate remodeling as a key indicator of smoke exposure induced IVD degeneration and inform the development of novel therapeutic strategies aimed at preserving or improving disc health.
What Do You Do Outside of Work? When and Why Disclosing Eudaimonic Leisure Activities Increases Competence Perceptions and Consumer Choice
Authors: Daniels Michelle E , Samper Adriana , Morales Andrea C 
Published: January 2025

Abstract
Consumers have increasing access to more holistic information about the providers they consider working with and hiring (e.g., realtors, designers), including how they spend their free time. This research examines how a professional’s disclosure of their leisure activities impacts consumer choice. While the way people spend their leisure time should be unrelated to their professional aptitude, across an online field study and four lab studies, the authors demonstrate that disclosing leisure activities associated with eudaimonic well-being (ie, meaning, fulfillment), such as hiking or cooking, can positively impact consumer choice. Such disclosures, relative to either not disclosing leisure or disclosing less eudaimonic activities such as relaxing or watching television, increase perceptions of competence, and in turn, interest in choosing, hiring, and supporting these individuals. Notably, the effects of eudaimonic leisure on competence and hiring intentions are attenuated if other diagnostic competence cues are present, such as a job- related award, and among those who value productivity less (ie, have a low productivity orientation). Thus, the authors show how seemingly irrelevant personal information about professionals can inform consumer choice. Moreover, by manipulating eudaimonic well-being via leisure disclosures, they demonstrate how such cues impact person perception, integrating research on well-being, self-disclosure, and social perceptions.
Pipsan Saarinen Swanson’s Life Model Home: Mediation and Mythmaking in Postwar America
Authors: Kowalski Alison 
Published: January 2025

Abstract
In a 1955 photographic essay, Life magazine published model interiors designed by Pipsan Saarinen Swanson, telling its readers they represented an authentic regional style called “Nordic Modern of the Midwest.” In this paper, I conduct a close visual and textual reading of the magazine spread as well as other archival documents related to Swanson’s model home. This reading I contextualize within design and cultural histories to demonstrate that Life framed the model home to suit its own agendas to, on the one hand, celebrate American culture and, on the other hand, promote modern design. I argue that in so doing, the magazine presented Swanson’s work in a manner that bolstered and expounded on a myth that had recently been circulating the design world in the United States. Promulgated by historians, writers, and designers, this myth revised the established history of modern design to relocate its origins from early twentieth-century Europe to pre-1900 America.