bluuebunny/crossref_metadata_2025_split huggingface dataset:
Türkiye: Public Law
Authors: Tekin-Apaydın Deniz 
Published: October 2023

Abstract
Since the multi-layered impact of Covid-19 pandemic, which began to effect Türkiye by mid-March 2020, Türkiye acceleratingly felt the severe economic consequences. The ongoing economic deterioration got worsened by the Russia-Ukraine war. Many economic measures were taken by the government to ease the hardships, along with a highly disputed economic policy pursued. With the upcoming elections in 2023, the government occurs to sharpen its policies and put in place proactive internal and external policies. Within this outlook, this report hereby presents a selection of public law related developments in Türkiye between October 2021 and October 2022. The report mostly focuses on developments concerning public international law, as they appear to stand out.
Whither Economic Studies in China?
Authors: Huang Philip C. C. 
Published: October 2023

Abstract
In socialist China today, neoliberal economics has actually come to wield institutionalized hegemonic power in academic evaluations of economic studies, while in neoliberal America, there is actually considerably more pluralism in the practice of academic evaluations of economic studies. The origins of this state of affairs lie not in just a simple matter of ideology or policy choices, but rather in different tendencies in the actual practices of two different systems of governance. While China leans strongly toward centralized bureaucratism, along with scientism and numericalism, the U.S. leans more toward multi-centered pluralistic practices. What scholarship needs is pluralistic contentions for sustained long-term development.
The Self-as-Disrupted
Authors: Fitzpatrick Melissa Andrea 
Published: October 2023

Abstract
This paper seeks to clarify and link Levinas’s understanding of who we are to both his metaphysics of conversation and his unique understanding of justice, suggesting that Levinas’s markedly religious understanding of the subject provides an important clue as to what constitutes meaningful dialogue, and what the work of philosophy – grounded in meaningful dialogue – ought to entail. Based on Levinas’s account, in addition to searching for order and clarity (making transcendence immanent), the task of philosophy is to safeguard thinking from the delusion that truth has been discovered once and for all. That is, to break up proposed identifications of truth, to reject ideology – to refuse to take order and clarity for granted, even at the risk of uncertainty, as this uncertainty is what allows for the possibility of an existential shift, a new way of understanding things, a new mode of being. This inevitably involves welcoming, in hospitality, the death that necessarily accompanies metanoia.
Applicability of Methods for Inflow Turbulence Generation Developed in a CFD Field to the Thermally Driven Convective Boundary Layer Simulations
Authors: Sato Takuto , Kusaka Hiroyuki 
Published: October 2023

Abstract
This study focuses on the application of two standard inflow turbulence generation methods for growing convective boundary layer (CBL) simulations: the recycle–rescale (R-R) and the digital filter–based (DF) methods, which are used in computational fluid dynamics. The primary objective of this study is to expand the applicability of the R-R method to simulations of thermally driven CBLs. This method is called the extended R-R method. However, in previous studies, the DF method has been extended to generate potential temperature perturbations. This study investigated whether the extended DF method can be applied to simulations of growing thermally driven CBLs. In this study, idealized simulations of growing thermally driven CBLs using the extended R-R and DF methods were performed. The results showed that both extended methods could capture the characteristics of thermally driven CBLs. The extended R-R method reproduced turbulence in thermally driven CBLs better than the extended DF method in the spectrum and histogram of vertical wind speed. However, the height of the thermally driven CBL was underestimated in about 100 m compared with the extended DF method. Sensitivity experiments were conducted on the parameters used in the extended DF and R-R methods. The results showed that underestimation of the length scale in the extended DF method causes a shortage of large-scale turbulence components. The other point suggested by the results of the sensitivity experiments is that the length of the driver region in the extended R-R method should be sufficient to reproduce the spanwise movement of the roll vortices.

Significance Statement
Inflow turbulence generation methods for large-eddy simulation (LES) models are crucial for the better downscaling of meteorological mesoscale models (RANS models) to microscale models (LES models). Various CFD methods have been developed, but few have been applied to simulations of thermally driven convective boundary layers (CBLs). To address this problem, we focused on a method that recycles turbulence [the recycle–rescale (R-R) method] and another method that synthetically generates turbulence [the digital filter–based (DF) method]. This study extends the R-R method to manage turbulence in thermally driven CBLs. In addition, this study investigated the applicability of the DF method to thermally driven CBL simulations. Both extended methods are effective for downscaling experiments and capture the characteristics of thermally driven CBLs.
Co-Creating Socio-Culturally-Appropriate Virtual Geriatric Care for Older Adults Living With HIV: A Community-Based Participatory, Intersectional Protocol
Authors: Kokorelias Kristina M. , Wasilewski Marina B. , Flanagan Ashley , Zhabokritsky Alice , Singh Hardeep , Dove Erica , Eaton Andrew D. , Valentine Dean , Sheppard Christine L. , Abdelhalim Reham , Parpia Rabea , Zewude Rahel , Jamieson Laura , Grosse Anna , Walmsley Sharon , Brown Paige , Sirisegaram Luxey 
Published: October 2023

The aging cohort of persons living with human immunodeficiency virus (HIV) in Canada has reached a critical point, with nearly half now 50 years age or older. Older persons living with HIV have specific needs which can be effectively addressed by geriatric specialists. However, the recognition of HIV care as a domain of geriatrics is recent, resulting in a lack of clinical recommendations and modern care models for delivering geriatric care to this population. Virtual care has been demonstrated to reduce existing barriers to accessing HIV care in some populations but before it can be adapted to geriatric HIV care a critical first step is to acknowledge and understand disparities in socioeconomic circumstances, technology access and ability and cultural differences in experiences. This protocol marks the initial step in a comprehensive program of research aimed at co-designing, implementing, and evaluating culturally-appropriate virtual geriatric care for diverse older adults living with HIV. The study employs qualitative methods with older adults living with HIV to lay the groundwork, to inform the future development of a virtual model of geriatric care. We will explore the perspectives of diverse groups of older persons with HIV on (1) The value and necessity of culturally-tailored virtual interventions for geriatric HIV care; and (2) Recommendations on how best to engage older persons with HIV in the future co-design of a virtual model of geriatric HIV care. Ultimately, a more culturally-appropriate approach to care will foster a more inclusive and supportive healthcare system for all individuals affected by HIV including those who are aging. Researchers can utilize this research protocol to employ qualitative co-design and participatory methods with diverse older adults living with HIV.
Lost to follow-up of patients who received intravitreal anti-vascular endothelial growth factor therapy to treat four different retina disorders in an individual center in Brazil
Authors: Takahashi Vitor Kazuo Lotto , Balbino Marcos , Ruppert Aline Domingos Pinto , de Carvalho Lais Soares , Seixas Regina Cele Silveira 
Published: October 2023

Objectives: To identify risk factors for loss to follow-up in periodic intravitreal anti-vascular endothelial growth factor injections for the treatment patients with diabetic macular edema, subretinal neovascularization, age-related macular degeneration, and retinal vein occlusion in a single eye center in São Paulo, Brazil. Methods: This was a retrospective longitudinal study that gathered information from 992 patients who required intravitreal anti-vascular endothelial growth factor drugs over 6 months. The authors included age, eye disease, laterality, monthly income, distance, and payment mode as risk factors. Results: Two hundred and seventy patients (29.93%) were lost to follow-up. Multivariate analysis showed age, monthly income, eye involvement, and type of medical assistance independently associated with loss to follow-up. The odds of loss to follow-up were greater among older patients than those less than 50 years (reference), p < 0.001. The odds of loss to follow-up were greater among patients who received unilateral treatment than those who received bilateral injections ( p = 0.013). Concerning gross monthly income, there were no differences in the odds of the four salary strata; the data also indicate an absence of difference in the three strata of patients’ distance to the clinic. Considering the diagnosis, only age-related macular degeneration showed greater odds of loss to follow-up ( p = 0.016). Finally, the data suggest greater odds of loss to follow-up in private patients than in those on a health care plan ( p < 0.001). Conclusion: Loss to follow-up is paramount because many patients may remain unassisted concerning their eye diseases. Identifying the risk factors is crucial to enforcing measures to increase adherence and the long-term success of the treatment.
Headache and sleep quality in mitochondrial diseases
Authors: Martin Alejandro Herrero San , Gonzalez Cristina Dominguez , Conejo Montserrat Morales , Salas Maria Elena Hernández , Gallego Jesús Hernández 
Published: October 2023

Objective: Describe the characteristics and prevalence of headache in patients with mitochondrial diseases (MDs), as well as sleep quality, trying to observe possible associations. To assess whether these patients are more likely to suffer headaches in relation to poorer quality of sleep. Background: Sleep disorders and headache are considered to be common in MDs. We present the largest sample analyzed to date. Methods: Observational, descriptive, cross-sectional study that analyzed a database of 232 patients with MDs, including age, sex, genotype, phenotype, presence and characteristics of headache. All patients fulfilled the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI) and, in migraine, the Migraine Disability Assessment questionnaire (MIDAS). Headache was divided into two groups: migraine headache, according to criteria of the International Classification of Headache Disorders (ICHD-III beta), and non-migraine headache. Results: A total of 203 cases were analyzed, 124 women (61%) and 79 men (39%). Average age was 46 years. Most frequent DNA mutation was m.3243 A > G in MITL1 gene (33%). Most frequent phenotype was MELAS syndrome: 28 patients (13.8%). Ninety-two patients (45.3%), reported headache, 44 fulfilling migraine criteria (21.7%). Headache was more frequent in MELAS syndrome ( p < 0.01). Statistically significant differences were found in the number of disabling episodes per month in patients with migraine ( p < 0.001). Patients with headache scored higher in Epworth ( p = 0.01) and Pittsburgh scales ( p < 0.001). Conclusions: A higher prevalence of migraine is observed in patients with mitochondrial diseases, independent of genotype and phenotype. MD-associated migraine tends to be chronic and more disabling. A higher frequency of headache, not specifically migraine, has also been observed in patients with MELAS syndrome. Mitochondrial dysfunction could be one of the pathophysiological mechanisms of migraine and a factor of chronification and severity. Poor sleep quality could also be associated with headache in patients with MDs. Assessment of headache and sleep disturbances should be part of the routine workup of patients with mitochondrial disease. Trial registration: N/A.
Development and usability testing of a fully immersive VR simulation for REBOA training
Authors: Birrenbach T. , Wespi R. , Hautz W. E. , Berger J. , Schwab P. R. , Papagiannakis G. , Exadaktylos A. K. , Sauter T. C. 
Published: October 2023

Abstract
Background
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potentially life-saving procedure for bleeding trauma patients. Being a rare and complex procedure performed in extreme situations, repetitive training of REBOA teams is critical. Evidence-based guidelines on how to train REBOA are missing, although simulation-based training has been shown to be effective but can be costly and complex. We aimed to determine the feasibility and acceptance of REBOA training using a fully immersive virtual reality (VR) REBOA simulation, as well as assess the confidence in conducting the REBOA procedure before and after the training.

Methods
Prospective feasibility pilot study of prehospital emergency physicians and paramedics in Bern, Switzerland, from November 2020 until March 2021. Baseline characteristics of trainees, prior training and experience in REBOA and with VR, variables of media use (usability: system usability scale, immersion/presence: Slater-Usoh-Steed, workload: NASA-TLX, user satisfaction: USEQ) as well as confidence prior and after VR training were accessed.

Results
REBOA training in VR was found to be feasible without relevant VR-specific side-effects. Usability (SUS median 77.5, IQR 71.3–85) and sense of presence and immersion (Slater-Usoh-Steed median 4.8, IQR 3.8–5.5) were good, the workload without under-nor overstraining (NASA-TLX median 39, IQR 32.8–50.2) and user satisfaction high (USEQ median 26, IQR 23–29). Confidence of trainees in conducting REBOA increased significantly after training (p < 0.001).

Conclusions
Procedural training of the REBOA procedure in immersive virtual reality is possible with a good acceptance and high usability. REBOA VR training can be an important part of a training curriculum, with the virtual reality-specific advantages of a time- and instructor-independent learning.
Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats
Authors: Tsuzawa Kayo , Onimaru Hiroshi , Inagaki Katsunori , Izumizaki Masahiko 
Published: October 2023

AbstractA metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential channel 1 in the spinal cord, although the role of cannabinoid receptors remains to be studied. The ventral root reflex response induced by stimulation of the dorsal root in in vitro preparations of rat spinal cord is useful to assess the effect of analgesics. We analyzed the effects of AM404 and cannabinoid receptor antagonist AM251 on reflex responses in lumbar spinal cord preparations from newborn rats and found that the amplitude of the slow ventral root potential after administration of 10 µM AM404 was not significantly changed, whereas 10 µM AM251 significantly increased the amplitude. Administration of the cannabinoid receptor 1 agonist WIN55,212-2 (10 µM) did not significantly affect the reflex response. We suggest that endogenous cannabinoids in the spinal cord are involved in the antinociceptive mechanism through suppressive effects.
IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells
Authors: Gao Junfeng , Li Yapeng , Guan Xiaoyu , Mohammed Zahraa , Gomez Gregorio , Hui Yvonne , Zhao Dianzheng , Oskeritzian Carole A. , Huang Hua 
Published: October 2023

Abstract
Background
Antigenic stimulation through cross-linking the IgE receptor and epithelial cell-derived cytokine IL-33 are potent stimuli of mast cell (MC) activation. Moreover, IL-33 primes a variety of cell types, including MCs to respond more vigorously to external stimuli. However, target genes induced by the combined IL-33 priming and antigenic stimulation have not been investigated in human skin mast cells (HSMCs) in a genome-wide manner. Furthermore, epigenetic changes induced by the combined IL-33 priming and antigenic stimulation have not been evaluated.

Results
We found that IL-33 priming of HSMCs enhanced their capacity to promote transcriptional synergy of the IL1B and CXCL8 genes by 16- and 3-fold, respectively, in response to combined IL-33 and antigen stimulation compared to without IL-33 priming. We identified the target genes in IL-33-primed HSMCs in response to the combined IL-33 and antigenic stimulation using RNA sequencing (RNA-seq). We found that the majority of genes synergistically upregulated in the IL-33-primed HSMCs in response to the combined IL-33 and antigenic stimulation were predominantly proinflammatory cytokine and chemokine genes. Moreover, the combined IL-33 priming and antigenic stimulation increase chromatin accessibility in the synergy target genes but not synergistically. Transcription factor binding motif analysis revealed more binding sites for NF-κB, AP-1, GABPA, and RAP1 in the induced or increased chromatin accessible regions of the synergy target genes.

Conclusions
Our study demonstrates that IL-33 priming greatly potentiates MCs’ ability to transcribe proinflammatory cytokine and chemokine genes in response to antigenic stimulation, shining light on how epithelial cell-derived cytokine IL-33 can cause exacerbation of skin MC-mediated allergic inflammation.
Transcriptome-wide identification and characterization of genes exhibit allele-specific imprinting in maize embryo and endosperm
Authors: Dong Xiaomei , Luo Haishan , Bi Wenjing , Chen Hanyu , Yu Shuai , Zhang Xiaoyu , Dai Yuxin , Cheng Xipeng , Xing Yupeng , Fan Xiaoqin , Zhu Yanbin , Guo Yanling , Meng Dexuan 
Published: October 2023

Abstract
Background
Genomic imprinting refers to a subset of genes that are expressed from only one parental allele during seed development in plants. Studies on genomic imprinting have revealed that intraspecific variations in genomic imprinting expression exist in naturally genetic varieties. However, there have been few studies on the functional analysis of allele-specific imprinted genes.

Results
Here, we generated three reciprocal crosses among the B73, Mo17 and CAU5 inbred lines. Based on the transcriptome-wide analysis of allele-specific expression using RNA sequencing technology, 305 allele-specific imprinting genes (ASIGs) were identified in embryos, and 655 ASIGs were identified in endosperms from three maize F1 hybrids. Of these ASIGs, most did not show consistent maternal or paternal bias between the same tissue from different hybrids or different tissues from one hybrid cross. By gene ontology (GO) analysis, five and eight categories of GO exhibited significantly higher functional enrichments for ASIGs identified in embryo and endosperm, respectively. These functional categories indicated that ASIGs are involved in intercellular nutrient transport, signaling pathways, and transcriptional regulation of kernel development. Finally, the mutation and overexpression of one ASIG (Zm305) affected the length and width of the kernel.

Conclusion
In this study, our data will be helpful in gaining further knowledge of genes exhibiting allele-specific imprinting patterns in seeds. The gain- and loss-of-function phenotypes of ASIGs associated with agronomically important seed traits provide compelling evidence for ASIGs as crucial targets to optimize seed traits in crop plants.
Effect of raw electroencephalogram-guided anesthesia administration on postoperative outcomes in elderly patients undergoing abdominal major surgery: a randomized controlled trial
Authors: He Ziqing , Zhang Hao , Xing Yahui , Liu Jia , Gao Yang , Gu Erwei , Zhang Lei , Chen Lijian 
Published: October 2023

Abstract
Background
EEG monitoring techniques are receiving increasing clinical attention as a common method of reflecting the depth of sedation in the perioperative period. The influence of depth of sedation indices such as the bispectral index (BIS) generated by the processed electroencephalogram (pEEG) machine to guide the management of anesthetic depth of sedation on postoperative outcome remains controversial. This research was designed to decide whether an anesthetic agent exposure determined by raw electroencephalogram (rEEG) can influence anesthetic management and cause different EEG patterns and affect various patient outcomes.

Methods
A total of 141 participants aged ≥ 60 years undergoing abdominal major surgery were randomized to rEEG-guided anesthesia or routine care group. The rEEG-guided anesthesia group had propofol titrated to keep the rEEG waveform at the C-D sedation depth during surgery, while in the routine care group the anesthetist was masked to the patient’s rEEG waveform and guided the anesthetic management only through clinical experience. The primary outcome was the presence of postoperative complications, the secondary outcomes included intraoperative anesthetic management and different EEG patterns.

Results
There were no statistically significant differences in the occurrence of postoperative respiratory, circulatory, neurological and gastrointestinal complications. Further EEG analysis revealed that lower frontal alpha power was significantly associated with a higher incidence of POD, and that rEEG-guidance not only reduced the duration of deeper anesthesia in patients with lower frontal alpha power, but also allowed patients with higher frontal alpha power to receive deeper and more appropriate depths of anesthesia than in the routine care group.

Conclusions
In elderly patients undergoing major abdominal surgery, rEEG-guided anesthesia did not reduce the incidence of postoperative respiratory, circulatory, neurological and gastrointestinal complications. rEEG-guided anesthesia management reduced the duration of intraoperative BS in patients and the duration of over-deep sedation in patients with lower frontal alpha waves under anesthesia, and there was a strong association between lower frontal alpha power under anesthesia and the development of POD. rEEG-guided anesthesia may improve the prognosis of patients with vulnerable brains by improving the early identification of frail elderly patients and providing them with a more effective individualized anesthetic managements.