bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Sequential Chemotherapy and hypofractionated Radiotherapy Combined with Comprehensive Surgical Resection for High-Risk Soft Tissue Sarcomas: A Retrospective Study
Authors: Qu Guoxin , Tian Zhichao , Wang Jiaqiang , yang Chengliang , Niu Xiaohui , Yao Weitao 
Published: January 2024

Abstract

Introduction:
The management of soft tissue sarcomas presents considerable therapeutic challenges. This study was designed to assess the efficacy of neoadjuvant sequential chemotherapy and hypofractionated radiotherapy in conjunction with extensive surgical resection for the treatment of high-risk soft tissue sarcomas.
Materials and methods
We performed a retrospective review of 31 high-risk soft tissue sarcoma patients treated at our institution from June 2021 to June 2023. The cohort consisted of 21 males and 10 females with a mean age of 55.7 years and included both initial and recurrent disease presentations. Our treatment regimen comprised two to three cycles of neoadjuvant chemotherapy coupled with hypofractionated radiotherapy, delivered at 5 Gy per fraction to a total dose of 25–35 Gy across 5–7 days, prior to surgical resection aimed at achieving wide margins. Data collection was systematic, covering surgical outcomes, chemoradiotherapy-related complications, and prognostic factors.
Results
All patients completed the prescribed course of neoadjuvant chemoradiotherapy. 29% patients experienced grade 3 + chemotherapy toxicity, necessitating a reduction or interruption in their chemotherapy regimen. Limb preservation was accomplished in 30 patients finally. Response evaluation using RECIST 1.1 criteria post-neoadjuvant therapy revealed 9.7% with PD, 58.1% with SD, 29% with a PR, and 3.2% with a CR, culminating in an ORR of 32.2%. Postoperative complications included superficial wound infections in four patients and deep incisional infections in another four. Two patients developed pulmonary metastases, two presented with multiple metastatic sites, and one experienced local recurrence. DFS rate was 83.9%, with a one-year OS rate of 88.2%.
Conclusion
Neoadjuvant sequential chemotherapy and hypofractionated radiotherapy followed by extensive surgical resection represents an effective treatment paradigm for high-risk soft tissue sarcomas. This multimodal approach not only facilitates tumor reduction but also significantly reduces the risks of local recurrence and distant metastasis.
The impact of CaTiO 3 -Ca 2 SiO 4 nanoparticles on the mechanical properties of an epoxy/polyvinyl acetate nanocomposite reinforced with carbon fibers
Authors: Alimirzaie Neda , Hamadanian Masood 
Published: January 2024

Abstract
In this study, CaTiO3-Ca2SiO4 (CT-CS) nanoparticles were synthesized via the sol-gel method. The nanocomposite was fabricated by the ultrasonic method with the addition of CT-CS nanoparticles, polyvinyl acetate (PVAc), and carbon fiber (CF) to the initial epoxy matrix. Response surface methodology-central composite design (RSM/CCD) was used to assess the impact of the weight percentage of the aforementioned ingredients on the mechanical behavior of epoxy resin. The chemical structure and morphologies of CT-CS nanoparticles and EP/PVAc/CT-CS/CF nanocomposites were assessed using FT-IR, SEM, TGA, and XRD studies. A tensile test was employed to assess mechanical properties, such as yield (MPa), area (J), modulus (MPa), stress (MPa), and strain (%). In light of this, the data gathered showed that the addition of additives had a notable impact on stress and tensile parameters in contrast to strain and area. Compared with CT-CS nanoparticles and PVAc, CF had a stronger effect in improving the mechanical properties of epoxy resin. The optimization results indicated a significant increase in stress (236.7 and 188.9%) compared to pure EP and EP/PVAc, whereas strain and area showed a slight decrease. A good synergistic effect that increases the overall stress in epoxy resin is produced by these three working well together.
Nanocellulose assisted microencapsulation of n-Octadecane with melamine formaldehyde resin shell by emulsion polymerization and its thermal energy storage characteristics
Authors: Jia Lingyun , Liu Wenli , Wang Wenxue , Fan Rong , liu pengtao 
Published: January 2024

Abstract
In this study, microcapsules obtained by emulsion polymerization were prepared for applications for thermal energy storage that use melamine formaldehyde resin as the wall material and n-Octadecane as the phase change material, where cellulose nanofiber (CNF) was used as an emulsion stabilizer. The results of CNF addition, core-to-wall mass ratio and reaction stirring rate on the attributes of microcapsules were investigated. The thermal attributes and the morphology of microcapsules were investigated by Scanner electron microscopy (SEM), Fourier transform infrared (FTIR), synchronous thermal analyzer (TA), differential scanning calorimeter (DSC), and X-ray diffraction (XRD). The findings revealed that the microcapsules up to the highest efficiency of encapsulation and energy storage of 59.1% and 58.5%, respectively, were achieved when the CNF addition was 0.2 wt%, the core-to-wall mass ratio was 3:3.69, and the stirring rate was 1000 r/min. This work uses CNF as an emulsion stabilizer instead of conventional emulsifiers, which reduces the burden on the environment and provides a sustainable method for thermal energy storage and conversion.
Half of most frequently mutated genes in breast cancer are expressed differentially between premenopausal and postmenopausal breast cancer patients
Authors: Berkel Caglar , Cacan Ercan 
Published: January 2024

Abstract

Breast cancer has distinct causes and molecular characteristics at premenopausal and postmenopausal ages. The age-standardized incidence rate for postmenopausal breast cancer is more than 10 times higher than in premenopausal breast cancer. Here, I showed that the expression of 10 out of 20 most frequently mutated genes in breast cancer (namely, PIK3CA, CDH1, MUC16, PTEN, FAT3, FAT1, SPEN, ARID1A, LRP1B and RUNX1) is higher in premenopausal women with breast cancer than in postmenopausal women with breast cancer. The most significant differences in the expression in terms of menopause status were observed for RUNX1 and FAT1. Furthermore, I found that the majority of these 10 genes also show ER (estrogen receptor) or PR (progesterone receptor) status-dependent expression in both premenopausal and postmenopausal breast cancer patients. Unlike what I observed in the case of ER or PR status, the expression of most of these genes does not change depending on HER2 (human epidermal growth factor receptor 2) status in both premenopausal and postmenopausal breast cancer patients. Combined, our analysis suggests that menopause status might influence the expression of most frequently mutated genes in breast cancer, and that the most of these genes whose expression differ between pre- and post-menopausal women with breast cancer also show ER or PR status-dependent expression in women with breast cancer.
Destruction of 2,4-dichlorophenol vapor in a process involving the combined action of DBD in oxygen and a catalyst
Authors: Lapshova K. А. , Gordina N. E. , Kvitkova E. Yu. , Izvekova T. V. , Grinevich V. I. , Gusev G. I. , Rybkin V. V. , Gushchin A. A. 
Published: January 2024

Abstract

In this work, the process of decomposition of 2,4-dichlorophenol (2,4-DCP) vapor under the influence of atmospheric pressure DBD in oxygen was studied. The studies were carried out in two modes: with a catalyst (natural vermiculite doped with zirconium) and without it. A number of basic characteristics of the catalyst were assessed. The rates and effective rate constants of sorption processes, as well as decomposition processes in plasma and plasma-catalytic systems, were determined. Based on these data, the energy efficiency of the decomposition process was calculated. The data obtained suggested that the initial stage of decomposition is the reaction of interaction of electrons with pollutant molecules. The catalyst has been shown to speed up the decomposition process, increase energy efficiency and the conversion of 2,4-DCP to CO2 molecules, and prevent the formation of condensed products on the reactor walls. The work estimates the carbon and chlorine balances before and after treatment, which reach a maximum of 99 and 60%, respectively. It was also shown that the catalyst retains its activity for at least 7 hours of continuous operation.
Effect of mineral additions on the chemical resistance of high-performance concrete
Authors: HADJI Tarek , ATTIA Ahmed , DOUARA Taha Hocine , GUETTALA Salim , QUENEUDEC Michèle 
Published: January 2024

Abstract
The aim of this paper is to assess the effect of the natural pozzolan (NP) and limestone filler (LF) on the Chimical resistance of high-performance concrete (HPC) in an aggressive environment. (NP) and (LF) were used to replace different proportions of cement (PC). HPCC(100%PC), HPC18(10%LF + 90%PC), HPC7(20%NP + 80%PC), and HPC14(5%LF + 10%NP + 85%PC) were mixed, cast, and cured in pure water for 28 days. The sorptivity coefficients S (cm*s-0.5) of these HPCs were then estimated, and the mass change measuring specimens were immersed in three different mediums: pure water, (5%HCl) acid, and (5%H2SO4) acid. Their masses' changes were measured after 30, 90, and 180 days of conservation. The substitution of (PC) by (LF) and (NP) decreased the sorptivity of (HPC) depending on the type and proportion of the mineral addition. In a medium (5%H2SO4), HPC18 and HPC14 exhibited good chemical resistance compared to that of HPC7. In a medium (5%HCl), the mass loss in HPC7 and HPC14 are less than those in HPC18. The mass losses were in the range 3.32-9.63% and 11.22-13.31% in (5%HCl) acid and (5%H2SO4) acid respectively. Which proves that the chimical attac by sulfuric acid is more agressif than that by hydrochloric acide. When a mass of (PC) was replaced by (10%LF), (20%NP) or (5%LF + 10%NP) the sorptivity decreased. The substitution of 10% of the (PC) mass by (LF) increased the HPC resistance against H2SO4 acid chemical attack. However, The substitution of (PC) by (NP) and (LF) reduced the HPC's resistance to hydrochloric acid's chemical attack.
Reactive transport modeling of carbon capture in soil amended with fast weathering silicate minerals
Authors: Khalidy Reza , Chiang Yi Wai , Santos Rafael M. 
Published: January 2024

Abstract
Mineralization of powder form of fast-weathering silicate minerals (e.g., wollastonite and diopside) is reckoned as a stable and relatively low-cost method for sequestrating atmospheric CO2 in agricultural and urban soils. While the process, called terrestrial enhanced weathering, has well shown the capacity of carbon drawdown in lab and field scale studies, the long-term evolution of formation/redissolution of weathering product is less discussed in the literature. This study assesses long-term carbonate formation and migration over the soil profile with a reactive transport model built within the Geochemist Workbench software package. The model is built on the basis of experimental design/ procedure conditions and accounts for intermittent irrigation regimes and kinetic dissolution/precipitation of minerals as well as calcite formation. Simulation results are indicative of the growth of sequestrated carbon beyond the short-term duration (up to 8.3 t CO2/ha) with dissolved form (e.g., bicarbonates) growing over time. The model also predicts a slow migration of carbonates to deeper layers over five years. The modeling outputs are inconsistent with experimental observations, highlighting inflow rate as a driving factor in the formation of carbonates and mass of dissolved carbonate efflux from the system.
Therapeutic Efficacy and Tolerability of Artemether-lumefantrine for Uncomplicated Plasmodium Falciparum Malaria in Niger, 2020
Authors: LAMINOU IBRAHIM MAMAN , ARZIKA IBRAHIMA , ADEHOSSI ERIC , MAMAN KABIROU , HADIZA JACKOU , COULIBALY ERIC , BAHARI-TOHON ZILAHATOU , AHMED JEHAN , SANOUSSI ELISHA , KOKO DANIEL 
Published: January 2024

Abstract

Background
Monitoring therapeutic efficacy is important to ensure the efficacy of artemisinin-based combination therapies (ACTs) for malaria. The current first-line treatment for uncomplicated malaria recommended by the National Malaria Control Program (NMCP) in Niger is artemether-lumefantrine (AL). In 2020, an in vivo study was carried out to evaluate clinical and parasitological responses to AL as well as the molecular resistance to the drug in three sentinel sites: Agadez, Tessaoua and Gaya in Niger.
Methods
A multi-center, single-arm trial was conducted according to the 28-day World Health Organization (WHO) 2009 therapeutic efficacy study protocol. Children between 6 months and 15 years with confirmed uncomplicated Plasmodium falciparum infection and 1,000-200,000 asexual parasites/µL of blood were enrolled and followed up for 28 days. Uncorrected and PCR-corrected efficacy results at day 28 were calculated, and molecular correction was performed by genotyping the msp1, msp2, and glurp genes. The pfK13 propeller, pfdhfr, pfdhps, pfcrt and pfmdr genes were analyzed by PCR and Sanger sequencing. The Kaplan-Meier curve assessed parasite clearance.
Results
A total of 225 patients were enrolled in the study. The adequate clinical and parasitological response after PCR correction was 98.9% (95% CI 96.4–101.0%), 92.2% (85.0-98.5%) and 97.1% (93.1–101.0%) in Gaya, Tessaoua and Agadez, respectively. No adverse events were observed. Ten mutations (SNP) were found, including 7 synonyms (K248K, G690G, E691E, E612E, C469C, G496G, P718P) and 3 non-synonyms (N594K, R255K, V714S). Two mutations emerged: N594K and V714S. The R255K mutation detected in Southeast Asia was also detected. The pfdhpsK540E and pfdhfrI164L mutations associated with high levels of resistance are absent. There is a reversal of chloroquine resistance.
Conclusion
The study findings indicate that AL is effective and well tolerated for the treatment of uncomplicated malaria in three sites in Niger. The emergence of a pfk13 propeller mutation requires additional testing such as the Ring Stage Assay and CRISPR/Cas9 to confirm the role of these emerging mutations.
Trial registration:
NCT05070520, October 7, 2021
Necrobia rufipes (De Geer, 1775) (Coleoptera: Cleridae) life history traits and its application in forensic entomology
Authors: ZONGO David , DRABO Samuel Fogné , OUEDRAOGO Théodore Y , ROMBA Rahim , PARE Prisca L , WANGO Antoine , TRAORE Fousséni , GNANKINE Olivier 
Published: January 2024

Abstract
Forensic entomology focused sarcosaprophagous insects and arthropods may provide a sound tool for assessment of Post Mortem Interval (PMI) and could provide scientific evidence for date of deaths. However, few data on necrophagous insect are available in many western African countries. The current study focused on Necrobia rufipes, an insect known to be appear on highly decomposed and skeletonized corpses of mammals. Our research aimed at examining some biological parameters of N. rufipes on pig and rabbit used as substrate under ambient conditions. As results, eggs took around 72 hours to hatch regardless substrate. The duration of larval stages was shorter on pigs than those found in rabbits and ranged from 2 to 11 days. Statistical analyses performed showed that substrates had a highly significant effect (P < .0001) on the life span of both adults female and male as well as on female oviposition. The life span of males fed on pig was significantly higher than those fed on rabbit, with values of 74.82 ± 10.34 and 27.55 ± 4.71 days respectively, while for females, the lifespan was 90.36 ± 10.77 and 36.67 ± 4.92 days on pigs and rabbits respectively. Moreover, N. rufipes laid more eggs on pigs ( 285.75 ± 56.94 ) than on rabbits (5.50 ± 1.14 eggs). Pigs remained the most preferred food substrate compared to rabbits and confirmed that they were a good model for forensic investigations. The Knowledge of these parameters could help to get skills for assessing the PMI.
Tracking pedogenic carbonate formation and migration in agricultural soils amended with crushed wollastonite ore- Evidence from field trials
Authors: Khalidy Reza , Chiang Yi Wai , Santos Rafael M. 
Published: January 2024

Abstract
Considered as a well-known carbon sequestration method, terrestrial enhanced rock weathering involves the application of crushed silicate-bearing minerals to urban and agricultural soils. Once dissolved in the soil-water system, alkaline minerals adjust the pH in a range favorable for pedogenic carbonate formation and, hence, atmospheric carbon drawdown. As a fast-weathering Ca-rich mineral, wollastonite is recognized as one of the primary candidates for this process. Although previous studies proved the potential of wollastonite to sequester carbon in croplands, no study has investigated the fate of wollastonite over the vertical profile of soil. Furthermore, no studies have investigated changes in the elemental composition of soils due to wollastonite amendment on a field scale. The present study presents the results of a multi-year sampling collection from different layers (0–15, 15–30, and 30–60 cm) of agricultural soil amended with wollastonite in Woodstock, Ontario, Canada. The impact of initial soil pH on pedogenic carbonate formation was also investigated with the inclusion of two more field trials. The results denoted wollastonite addition increases the inorganic carbon pool of soil up to 6.60 t CO2/ha at higher (20 t/ha) wollastonite dosage. The elemental composition and mineralogy analyses were indicative of weathering occurrence in soil samples. This study indicates that carbonate formation is not limited to surficial layers, and deeper layers also need to be taken into account for estimating carbon capture due to ERW practice.
Targeted triterpenoids from Dysoxylum alliaceum stem barks as cytotoxic agents in human cancer and normal cells
Authors: Riyadi Sandra Amalia , Naini Al , Mayanti Tri , Farabi Kindi , Lesmana Rony , Azmi Mohamad Nurul , Fajriah Sofa , Supratman Unang 
Published: January 2024

Abstract
The Dysoxylum genus that belongs to the Meliaceae family is widely distributed from India and Srilanka throughout Malaysia and Indonesia to Australia and New Zealand. Numerous types of compounds have been reported, including sesquiterpenoids, limonoids, triterpenoids, and alkaloids. One of the members of this genus is Dysoxylum alliaceum. Reports on the phytochemical constituents of this species are limited. During our search for naturally occurring tropical plant compounds with intriguing structures and biological properties, the stembark of D. alliaceum, which showed cytotoxic activity against MCF-7, A549, and CV-1 cell lines, was investigated. This paper describes the chemical structure of the isolated compounds using HR-ESI-MS, FTIR, and NMR. As a result, eight triterpenoid compounds belonging to tirucallane-type (1–8) were identified, including cneorin-NP36 (1) toonapubesin A (2), toonapubesin B (3), chisopanin M (4), 21-α methylmelianodiol (5), 21-β methylmelianodiol (6), hispidone (7), and odoratone (8). Furthermore, toonapubesin A (2) showed the highest selectivity against A549 cancer cell lines with IC50 value 7.81 ± 0.02 µM, resulting in no activity towards CV-1 cells.
Antioxidant compounds produced by endolichenic fungus Penicillium sp. induced from Pyxine subcinerea
Authors: Kawakami Hiroko , Watabe Nao , Matsubuchi Yuko , Hara Kojiro , Komine Masashi 
Published: January 2024

Abstract
Endolichenic fungi are expecting for new bioresources of pharmacological compounds. However, the number of investigations targeting antioxidant compounds produced by endolichenic fungi remains limited. To discover new antioxidant compounds, we analyzed the antioxidant activity of 59 methanol extracts derived from isolated lichen mycobionts or endolichenic fungi induced from Pyxine subcinerea. We performed this analysis using the oxygen radical absorbance capacity (ORAC) method. As a result, we isolated from an endolichenic fungus identified as Penicillium sp. in Pyxine subcinerea. This fungus produced a red pigment, and its chemical structure was determined to be sclerotioramine based on the analytical data obtained from NMR, LC-MS/MS, and HPLC-PDA. Sclerotioramine exhibited high antioxidant activity, and the ORAC values (mean ± SD) of sclerotioramine and sclerotiorin were 11.4 ± 0.36 and 4.86 ± 0.70 mmol TE per gram of the respective pure compound. Thus, the antioxidant activity of sclerotioramine was greater than twice that of sclerotiorin. This work represents the first report that the antioxidant activity of sclerotioramine is higher than that of the sclerotiorin.
Experimental investigation into the mechanical and microscopic properties of cemented aeolian sand-coal gangue-fly ash backfill
Authors: Zheng Zhijun , yang baogui , Yang Faguang , Gu Chengjin , Liu Hao 
Published: January 2024

Abstract
This paper investigates that the influence of the independent variables of particle size of coal gangue (CG), concentration and coal gangue content on the UCS of cemented aeolian sand (AS)-coal gangue-fly ash (FA) backfill (CACFB) mixtures through the thermogravimetric, piezomercurial, microscopic experimental means by adding certain particle size of coal gangue particles in the cemented aeolian sand -fly ash backfill (CAFB) mixtures. Through the relevant experiments, the following conclusions are drawn: 1. with the increasing particle size of CG particles, the UCS of the CACFB is increasing in which the 7d UCS of R-C-1, R-C-2, R-C-3 and R-C-4 were 2.05 MPa, 2.11 MPa, 1.94 MPa and 2.09 MPa, respectively; 2. After 7 days of curing age, the UCS of CACFB is generally 1.5 MPa higher than that of CAFB.; 3. Because CG particles play a role in increasing slurry concentration, compactness and improving particle gradation in CACFB, the UCS of CACFB is much higher than the UCS of CAFB.; 4. The improvement UCS of CACFB will greatly improve the popularization and application of filling mining in northern Shaanxi mining area, and reduce the damage to environmental water resources and land resources in the mining area.
prognostic values of BOLA family members and correlated with immune infiltrates in Pancreatic adenocarcinoma
Authors: Long Quanyi , Fan Yuan 
Published: January 2024

Abstract
Background The BOLA gene family is related to iron homeostasis, consists of three members. Evidence have shown that BOLA family is associated with lung adenocarcinoma, ovarian cancer and hepatic cellular carcinoma. However, the BOLA family's rule in pancreatic adenocarcinoma(PAAD) is poorly understood.
Methods we analyzed the expression, prognostic value, and genetic alteration of BOLA family in PAAD patients by several online databases, including Gene Expression Profiling Interactive Analysis, Human Protein Atlas, Kaplan–Meier plotter, cBioPortal and The Database for Annotation, Visualization and Integrated Discovery. Besides, we also investigated the relationship between BOLA family and tumor immune infiltration by The Tumor Immune Estimation Resource (TIMER)
Results The pan-cancer analysis showed the mRNA expression levels of the BOLA family is higher in PAAD tissues than in normal pancreatic tissues, high expression of three BOLA family members were associated with elevated expression of BOLA1 was associated with overall survival (OS) and disease-free survival (DFS) in PAAD, the elevated expression of BOLA2 and BOLA3 were related to shorter DFS. Besides, expression level of BOLA1 was negatively correlated with B cells, CD8+ T cells, macrophages, neutrophil and Dendritic cells, while BOLA2 expression level was negatively correlated with CD8 + T cells, macrophages and Dendritic cells, BOLA3 expression level was correlated with neutrophil. Gene set enrichment analysis showed that BOLA family members were mainly relevant to intracellular iron-sulfur cluster assembly, iron ion homeostasis and cellular redox homeostasis in PAAD.
Conclusion The BOLA family expression was associated with prognosis and immune infiltrates in PAAD, Our findings help to add to the limited prognostic markers in PAAD, and the BOLA family may serve as potential targets for immunotherapy.