bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive evaluation of coal mine pit lake hydrological connectivity in South Kalimantan, Indonesia
Authors: Triwibowo Didik , Elma Muthia , Suhartono Eko , Riduan Rony 
Published: December 2023

Abstract
This study presents the first comprehensive evaluation of an ex-coal mine pit lake at a landscape scale in Indonesia, using a hydrological connectivity approach. The stability of the water balance and water quality of a pit lake depends on the condition of the catchment area, which functions as a source of water inflow. To assess this, a combination of Remote Sensing (RS) and Global Information Systems (GIS) techniques, along with field surveys e.g., bathymetric, and hydraulic survey, infiltration rate testing, and soil sampling for geochemical analysis, was used. The study focused on the Paringin pit lake, situated in a rehabilitated catchment area, and its hydrological connections from upstream to downstream in which the lake plays important hydrological function. The evaluation of Paringin pit lake catchment area resulted in the first Normalized Difference Vegetation Index (NDVI) map for the land cover assessment of the pit lake's catchment area in Indonesia. It is concluded that with the proportion of the pit lake and good catchment area being 1:7 in a tropical climate with rainfall of more than 3,000 mm/year and evaporation of 1,000 mm/year, the lake will become a flow-through lake with good water quality.
WITHDRAWN: Causal relationship between immune cells and idiopathic pulmonary fibrosis based on Mendelian randomization analysis
Authors: Gong peng , Lu yimin , Li man , Li xiaobo , Carla Cristina Janjacomo 
Published: December 2023

Abstract
Context:
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease (ILD) characterized by respiratory disease with a pathogenesis closely linked to collagen fibrin deposition and autoimmunity, although the mechanism of action is unclear. The immune system is a diverse and complex system that employs its own defense functions to maintain homeostasis. The lungs are connected to the outside world, and immune cells play an important role. Therefore, the interaction between immune cells and the lungs is decisive for IPF disease progression and treatment. However, studies on immune cells have limitations, and there are no concrete conclusions at present, limiting to some extent the development of immunology in IPF. To identify immune cells associated with IPF, the relationship between immune cells and IPF was explored based on the Mendelian randomization (MR) method.
Materials and Methods
This study utilized two-sample Mendelian randomization analysis to confirm the causal relationship between immune cells and IPF. Based on the GWAS database and the immune cell database, MR analysis was performed using R software to explore the causal relationship between 731 immune cells and IPF, mainly through inverse variance weighting (IVW). Finally, the reliability of the results was analyzed, and scatterplots, forest plots and funnel plots were drawn using MR_heterogeneity, horizontal pleiotropy and leave-one-out analysis.
Results
The MR analysis identified 6 immune panels and 23 immune traits that were causally associated with IPF. including B-cell panel, myeloid cell panel, monocyte panel, maturation stages of T-cell panel, TBNK panel, and Treg panel. However, there was no significant causal relationship between IPF disease and immune traits, and the immune traits that increased IPF included the following (p < 0.05), (see Table 1).
Conclusion: This study demonstrated a causal link between immune cells and IPF by genetic database and two-sample MR analysis, mainly by Sw mem% B cell, IgD- CD38dim% B cell, CD25 on CD4 Treg, CD45RA+ CD28- CD8br% T-cell and CD45RA+ CD28- CD8br AC modulation of immune expression occurs in idiopathic pulmonary fibrosis. This provides a theoretical.
The Effect of Inderal On Polymorphic Ventricular Tachycardia: Case report
Authors: Nassari Zeinab , Shafiee Mohsen , Tahery Noorollah , Baradaran Abdolvahab , Tabahfar Raha , Mohamadidarveshvan Elham , ShaabanZadeh Javad , Baghrobehbahani Alireza 
Published: December 2023

Abstract
Ventricular tachycardia (VT) has a destructive effect on people's health and heart. VT is a major cause of mortality among patients with cardiovascular diseases. The drug treatment of VT is highly sensitive and is selected according to the patient's condition. A 42-year-old man was admitted to the emergency department with dyspnea, Levine sign, and severe chest pain. His EKG showed ST elevation, and the QT interval was normal. The patient was sent to the cath lab based on the treatment protocols. According to the results of angiography, three coronary arteries were severely obstructed. His coronary arteries did not open during PCI; thus, the healthcare team decided on open heart surgery. He suffered from recurrent polymorphic VT following open heart surgery and did not respond to any of the drugs suitable for this type of tachycardia. Inderal prevented the recurrence of VT in a patient with polymorphic VT, which, contrary to the healthcare team's expectations. Inderal was used as the last line of treatment because this patient's arrhythmia was polymorphic VT. Inderal is mainly used in monomorphic VT and in patients with heart structure disorders. The result of the present study demonstrates the effect of the antiarrhythmic drug Inderal on polymorphic VT.
Sex differences in Guinea Pigs' Performance in a Spatial Navigation Task
Authors: Scandurra Anna , Sadile Francesca , Lucrezia Alfredo Di , Pinelli Claudia , D’Aniello Biagio , Silvestre Pasqualino , Marcianó Antonino , Pero Maria Elena , Mastellone Vincenzo , Lombardi Pietro 
Published: December 2023

Abstract
Spatial navigation has been extensively investigated for detecting sex differences in mammals, and the domesticated guinea pig (Cavia aperea porcellus) serves as a promising species for such studies, due to distinct parental investment between the sexes. In our exploration of sex-related effects on spatial navigation, we focused on the learning performance and spatial strategy (allocentric or egocentric) employed by guinea pigs in a plus maze paradigm. Results show that 50% of the animals completed the spatial navigation test. Regarding sex differences, 24.2% of females completed the test, while the completion rate for males was significantly higher at 64%. Males achieved the learning criterion with a significantly lower number of trials compared to females, indicating superior spatial abilities in the plus maze paradigm. Like their wild counterparts, male domestic guinea pigs exhibited better spatial skills than females. However, we observed no sex difference in the preference of strategy or the latency of task resolution.
Subjective global assessment, symptoms, blood nutritional indicators and the associated factors in pancreaticobiliary tumor patients
Authors: chen zhenyan , Wang Ming , Xu Simiao , Yao Ying 
Published: December 2023

Abstract

Objective: We aimed to investigate the subjective global assessment (SGA), symptoms and blood nutritional indicators in pancreaticobiliary tumor patients and the associated factors.
Method: 153 pancreaticobiliary tumor patients’ information was collected on admission including SGA, symptoms, blood lymphocyte count (Lmy), hemoglobin (Hb), creatinine (Cr), total cholesterol (TC), total triacylglycerol (TG), serum C-reactive protein (CRP), globulin, albumin (Alb), prealbumin (PA), transferrin (Tf), retinol binding protein (RBP) and micro-nutrients (folic acid, vit B12, vit A, vit E, vit K, vit D, iron, zinc and copper). Associated factors were explored.
Result: Advanced tumor stage, elevated CRP and CA 19-9 were risk factors for malnutrition by SGA; elevated CRP contributed to fatigue, anorexia and pain; Alb, PA and Tf decreased with age; men were associated with decrease of Lmy, folic acid and TC, and increase of vit D; advanced tumor stage was associated with elevated vit B12;elevated CRP was associated with decreased Hb, Alb, PA, Tf, RBP, vit A, vit D and increased globulin and copper; SGA was associated with decreased Lym, HB, Alb, PA and Tf; elevated bilirubin was associated with decreased Cr , Alb, vit K and vit D, and increased TC, TG, vit B12 and copper;
Conclusion：Inflammation should be controlled to relieve the discomforts; old patients should give more protein; gender affects nutritional indicators; advanced cancer underestimates vitB12 deficiency. Inflammation overestimates the deficiency of serum protein, vit A, vit D, iron and zinc.Malnutrition by SGA increases the deficiency of Lym and serum protein. Obstructive jaundice increases the deficiency of Cr, Alb, vit D and vitK, and cause vitB12 elevation, hyperlipemia, and copper accumulation.
Rapid and highly sensitive detection of bacterial pathogens using AgSnO/Si chip
Authors: Mateen Abdul , Ali M. Yasir , Hussain M. Sharafat , Ashraf Fouzia , Ikram S. , Javaid K. , Amin N. , Sajjad Muhammad Tariq , Ali Adnan , Mahmood Khalid 
Published: December 2023

Abstract
Surface-enhanced Raman scattering (SERS) is an important technique for detecting and identifying various chemical and biological species. In this study, we developed a low-cost, uniform, and stable SERS chip based on AgSnO/Si nanostructures for the detection of Tuberculosis (TB) and E. coli bacteria. We demonstrate that the post-annealing temperature significantly impacts the crystallinity, surface morphology, and resulting Raman signal of the chip. The highest enhancement in the Raman signal was achieved at a post-annealing temperature of 800 °C with more than ten times higher enhancement than that on a glass substrate (around 1622cm-1). This improved performance can be attributed to enhanced carrier concentrations in the host SnO due to oxygen related donor defect sites and a large surface area for adsorption due to the rough surface morphology of the AgSnO/Si chip. Further, the stability of the chip was confirmed by reproducing the same results after 12 months, and uniformity through identical Raman signals from different parts of the substrate. Hence, we demonstrate that rapid and accurate detection of bacterial pathogens is possible with a cost-effective AgSnO/Si chip.
Artificial intelligence-enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes
Authors: Irlik Krzysztof , Aldosari Hanadi , Hendel Mirela , Kwiendacz Hanna , Piaśnik Julia , Kulpa Justyna , Ignacy Paweł , Boczek Sylwia , Herba Mikołaj , Kegler Kamil , Coenen Frans , Gumprecht Janusz , Zheng Yalin , Lip Gregory Y. H. , Alam Uazman , Nabrdalik Katarzyna 
Published: December 2023

Abstract
Background
Cardiac autonomic neuropathy (CAN) is an important yet often overlooked complication of diabetes, which significantly increases the risk of cardiovascular (CV) events and mortality. Traditional diagnostic methods like CV autonomic function tests (CARTs) are laborious and rarely evaluated in clinical practice. This study aimed to develop and employ machine learning (ML) algorithms to analyze electrocardiogram (ECG) for the diagnosis of CAN.
Methods
We utilized motif and discord extraction techniques alongside Long Short-Term Memory (LSTM) networks to analyze 12-lead, 10 seconds ECG tracings to detect CAN in patients with diabetes. The performance of these methods with the Support Vector Machine (SVM) classification model was evaluated using Ten-Cross Validation (TCV) with the following metrics accuracy, precision, recall, F1 score, and area under the ROC Curve (AUC).
Results
Among 205 patients (mean age 54 ± 17; 54% female), 100 were diagnosed with CAN, including 38 with definite or severe CAN (dsCAN) and 62 with early CAN (eCAN). The best model performance for dsCAN classification was achieved using both motifs and discords, with an accuracy of 0.92, an F1 score of 0.92, a recall at 0.94, a precision of 0.91, and an excellent AUC of 0.93 (95%CI 0.91-0.94). For the detection of any stage of CAN, the approach combining motifs and discords yielded best results with an accuracy of 0.65, F1 score of 0.68, a recall of 0.75, a precision of 0.68, and an AUC of 0.68 (95%CI 0.54-0.81).
Conclusion
Our study highlights the potential of using ML techniques, particularly motifs and discords, to effectively detect dsCAN in patients with diabetes. This approach could be applied in large-scale screening of CAN, particularly to identify definite/severe CAN where CV risk factor modification may be initiated.
Genome-wide identification and expression profiling of PIN-PILS family genes in barley reveal potential role in spikelet abortion and abiotic stress tolerance
Authors: Shahzad Ali , Gul Shareef , Gul Hameed , Shahzad Muhammad , Ullah Asad 
Published: December 2023

Abstract
Auxin profoundly shapes plant growth and development, directing morphogenesis and adaptive responses. PIN and PILS family genes facilitate auxin transport, influencing its movement between plant cells and intracellular accumulation. However, systematic studies on PIN and PILS genes in barley are lacking. Here, we identified 14 PIN and 7 PILS genes in Hordium vulgare, establishing their evolutionary relationships with Arabidopsis, Brachypodium, maize, rice and wheat. Through analysis, we explored the physical properties, motifs, cis-regulatory elements, chromosomal location, collinearity, protein interactions, miRNA targets, and expression patterns of HvPIN-PILS genes across tissues, spikelet abortion, and stresses. We discovered cis-regulatory elements in the promoter region associated with plant development and stress, highlighting their potential roles. Moreover, our network analysis revealed interactions between HvPIN-PILS proteins and auxin signaling pathway components, underlining their critical regulatory functions in barley's growth and stress management. Our results indicated that mostly HvPIN-PILS genes highly expressed in Morex genotype during apical spikelet abortion stages. These findings pave the way for future research to enhance growth and stress tolerance in barley and related species by exploring the functions of PIN-PILS genes.
The German research consortium for the study of bipolar disorder (BipoLife): A quality assurance protocol for MR neuroimaging data
Authors: Vogelbacher Christoph , Sommer Jens , Bopp Miriam H. A. , Falkenberg Irina , Ritter Philipp S. , Bermpohl Felix , Attar Catherine Hindi , Einenkel Karolin E. , Gruber Oliver , Juckel Georg , Flasbeck Vera , Hautzinger Martin , Pfennig Andrea , Matura Silke , Reif Andreas , Grotegerd Dominik , Dannlowski Udo , Kircher Tilo , Bauer Michael , Jansen Andreas 
Published: December 2023

Abstract

Background
The German multicenter research consortium BipoLife aims to investigate the mechanisms underlying bipolar disorders. It focuses in particular on people at high risk of developing the disorder and young patients in the early stages of the disease. Functional and structural magnetic resonance imaging (MRI) data was collected in all participating centers. The collection of neuroimaging data in a longitudinal, multicenter study requires the implementation of a comprehensive quality assurance (QA) protocol. Here, we describe this protocol and its impact on the analysis of data on the patient-level.
Methods
The QA protocol consisted of (1) a training of participating research staff, (2) regular phantom measurements to evaluate the MR scanner performance and its temporal stability across the course of the study, and (3) the assessment of the quality of human MRI data by evaluating a variety of image metrics (e.g., signal-to-noise ratio, ghosting level). In this article, we will provide an overview on these QA procedures and show exemplarily the influence of its application on the results different analysis pipelines.
Discussion
The QA protocol helped to characterize the various MR scanners, record their performance over the course of the study and detect possible malfunctions at an early stage. It also assessed the quality of the human MRI data systematically to characterize its influence on various analyses. Furthermore, by setting up and publishing this protocol, we define standards that must be considered when analyzing data from the BipoLife consortium. It further promotes approaches to systematically consider aspects of data quality and to implement standardized analysis methods and subject selection criteria. In the long term, it will help to increase the chance of achieving clinically relevant results.
Metabolic dysfunction-associated fatty liver disease increases the risk of complications after radical resection in patients with hepatocellular carcinoma
Authors: Xiong Ke-Gong , Ke Kun-Yu , Kong Jin-Feng , Lin Tai-Shun , Lin Qing-Biao , Lin Su , Zhu Yue-Yong 
Published: December 2023

Abstract

Background and aims:
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in hepatocellular carcinoma (HCC) patients is increasing, yet its association with postoperative complications of HCC remains unclear. The aim of this study was to investigate the impact of MAFLD on complications after radical resection in HCC patients.
Methods
Patients with HCC who underwent radical resection were included. Patients were stratified into MAFLD group and non-MAFLD group. Clinical features and post-hepatectomy complications were compared between the two groups, and logistic regression analysis was used to determine independent risk factors associated with post-hepatectomy complications.
Results
Among the 936 eligible patients with HCC who underwent radical resection, concurrent MAFLD was diagnosed in 201 (21.5%) patients. Compared to the non-MAFLD group, the MAFLD group exhibited a higher incidence of complications, including infectious and major complications after radical resection in HCC patients. The logistic regression analysis found that MAFLD was an independent risk factor for complications, including infectious and major complications in HCC patients following radical resection (OR 1.565, 95%CI 1.109–2.343, P = 0.012; OR 2.092, 95%CI 1.386–3.156, P < 0.001; OR 1.859, 95% CI 1.106–3.124, P = 0.019; respectively). Subgroup analysis of HBV-related HCC patients yielded similar findings, and MAFLD patients with type 2 diabetes mellitus (T2DM) exhibited a higher incidence of postoperative complications compared to those without T2DM (all P < 0.05).
Conclusions
Concurrent MAFLD was associated with an increased incidence of complications after radical resection in patients with HCC, especially MAFLD with T2DM.
Addition of an NK1 receptor antagonist to standard antiemetic prophylaxis in patients with B-cell lymphoma receiving EPOCH
Authors: English Sloane , Lei Matthew , Sorial Mark N , Roeland Eric , Lou Uvette 
Published: December 2023

Abstract

Purpose
Data on the optimal management of patients with hematologic malignancies and chemotherapy-induced nausea and vomiting (CINV) are lacking. We report our institutional experience in patients with B-cell lymphoma receiving multiday dose-adjusted R-EPOCH chemotherapy.
Methods
We performed a retrospective, single-center, cohort study evaluating hospitalized patients with aggressive non-Hodgkin B-cell lymphoma receiving DA-R-EPOCH (April 2016 to October 2022). All patients received a corticosteroid and 5HT3RA and categorized by the addition of an NK1RA or not. The primary outcome was complete response (CR, no vomiting, and no rescue medication use) over 120 hours. Secondary outcomes included as-needed antiemetic use (acute, delayed, and overall phases), CR without escalating prophylactic antiemetics in cycle 2, and complete control. We performed a descriptive analysis and multivariate logistic regression for NK1RA use, adjusting for age and sex.
Results
Of 128 patients, 56 (43.8%) received an NK1RA as part of their antiemetic regimen, and 72 (56.3%) did not. No patients received prophylactic olanzapine. CR was achieved in 32 (57.1%) of those who received an NK1RA and 30 (41.7%) who did not (OR 0.45; 95% CI, 0.21–0.96; p = 0.039). We observed trends between groups in as-needed antiemetics use (29 [51.8%] vs. 49 [68.1%]; p = 0.061), with most use in the delayed phase (22 [39.3%] vs. 37 [51.4%], p = 0.173). We found no difference in healthcare utilization between the first and second cycle or in CR with escalation of cycle 2 prophylactic antiemetics.
Conclusion
CINV control in patients with non-Hodgkin B-cell lymphoma receiving DA-R-EPOCH in the hospital was suboptimal. These data support the need to optimize prophylactic antiemetic regimens for patients receiving DA-R-EPOCH.
Modelling of a parameterizable moving heat source for Ansys Mechanical
Authors: Favaretti Piero , Parussini Lucia , Favaretti Piero 
Published: December 2023

Abstract
Moving Heat Sources (MHSs) have multiple applications, most commonly in metal welding and cutting. For several years, Ansys has provided a free-to-download Application Customization Toolkit (ACT) Extension to define a moving heat flux. Although this tool is very useful, it has some limitations. Firstly, only the axisymmetric Gaussian power distribution is available, which is valid in many cases, but, for specific applications, other heat distributions such as the elliptical one may be preferred. Secondly, the ACT extension is not suitable for pulsed power sources. On/off processes can be in principle described as a sequence of single short and continuous impulses, but this approach is quite inefficient. Additionally, the standard version requires the power intensity as input, which is typically unknown and must be derived from the total power, adding an extra computation and increasing the risk of mislead. Another disadvantage is that the heating pattern is dependent on the geometry, requiring a predefined path. These limitations can be acceptable for a single simulation, but if the simulated process needs to be optimized, a different strategy for defining the moving heat source is required to allow parameterization of optimization input variables such as speed and pulse, just to name a few. To overcome these limitations, a generalized version of MHS is proposed. All parameters, including the heating pattern, are defined numerically, allowing for full customization and parameterization.
IFITM1 is a host restriction factor that inhibits porcine epidemic diarrhea virus infection
Authors: Cheng Jiahao , He Jiayi , Feng Simeng , Tan Lei , Wei Dong , Wang Aibing , Yuan Xiaomin 
Published: December 2023

Abstract

Interferon-induced transmembrane proteins (IFITMs) play an important role in the innate immune response triggered by viral infection. Porcine epidemic diarrhea virus (PEDV) is a pathogen causing intestinal infectious diseases in pigs. The current study provided overexpression of IFITM1 could suppress the proliferation of PEDV in IPEC-J2, while knockdown of it had opposite effect. Furthermore, co-localization of IFITM1 with PEDV virions could be observed, with the former mainly residing in the cytoplasm surrounding the nucleus, as revealed by IFA. Intriguingly, a phenomenon of IFITM protein embedded on the surface of virions was revealed by immunocolloidal gold electron microscopy. Moreover, we identified that the IFITM1 binds to the N protein of PEDV via CO-IP. Notably, Further investigations revealed that the CTD mutations of IFITM1 greatly compromised its inhibitory function on PEDV proliferation, with the amino acid residues 113 to 117 in this domain of it having a pronounced effect. Collectively, these findings suggest that IFTIM1 exerts an inhibitory function in PEDV infection, with the residues and structural motifs in the CTD of IFITM1 having fundamental effect on this modulatory actio.