bluuebunny/crossref_metadata_2025_split huggingface dataset:
DON of Hope: Starving Pancreatic Cancer by Glutamine Antagonism
Authors: Pillai Ray , Papagiannakopoulous Thales 
Published: December 2023

Abstract
A promising approach to treat solid tumors involves disrupting their reliance on glutamine, a key component for various metabolic processes. Traditional attempts using glutamine inhibitors like 6-diazo-5-oxo-L-norleucine (DON) and CB-839 were unsuccessful, but new hope arises with DRP-104, a prodrug of DON. This compound effectively targets tumor metabolism while minimizing side effects. In a recent study published in Nature Cancer, Encarnación-Rosado and colleagues demonstrated in preclinical models that pancreatic ductal adenocarcinoma (PDAC) responds well to DRP-104, although tumors adapt through the MEK/ERK signaling pathway, which can be countered by the MEK inhibitor trametinib. In a related study, Recouvreux and colleagues found that DON is effective against pancreatic tumors, revealing that PDAC tumors upregulate asparagine synthesis in response to DON, making them susceptible to asparaginase treatment. Both studies underscore the potential of inhibiting glutamine metabolism and adaptive pathways as a promising strategy against PDAC. These findings pave the way for upcoming clinical trials utilizing DRP-104 and similar glutamine antagonists in the battle against solid tumors.
A Civil Aviation Customer Service Ontology and Its Applications
Authors: Lv Meixiang , Cao Xudong , Wu Tianxing , Li Yuehua 
Published: December 2023

ABSTRACT
In the process of developing the C919 large aircraft customer service intelligence system, we find that heterogeneous and incomplete data cause the inefficient and inaccurate decision making. Thus, to solve this problem, we propose to introduce the idea of ontology modeling and reasoning into competitive intelligence system building in this paper. We first present the building principles and methods of the civil aviation customer service ontology. We then define the classes and properties to contribute a real-world civil aviation customer service ontology, which is published on the Web (http://www.openkg.cn/dataset/cacso). We finally design SWRL rules corresponding to different intelligence analysis targets to support reasoning in our designed competitive intelligence system.
AfriSpeech-200: Pan-African Accented Speech Dataset for Clinical and General Domain ASR
Authors: Olatunji Tobi , Afonja Tejumade , Yadavalli Aditya , Emezue Chris Chinenye , Singh Sahib , Dossou Bonaventure F. P. , Osuchukwu Joanne , Osei Salomey , Tonja Atnafu Lambebo , Etori Naome , Mbataku Clinton 
Published: December 2023

Abstract
Africa has a very poor doctor-to-patient ratio. At very busy clinics, doctors could see 30+ patients per day—a heavy patient burden compared with developed countries—but productivity tools such as clinical automatic speech recognition (ASR) are lacking for these overworked clinicians. However, clinical ASR is mature, even ubiquitous, in developed nations, and clinician-reported performance of commercial clinical ASR systems is generally satisfactory. Furthermore, the recent performance of general domain ASR is approaching human accuracy. However, several gaps exist. Several publications have highlighted racial bias with speech-to-text algorithms and performance on minority accents lags significantly. To our knowledge, there is no publicly available research or benchmark on accented African clinical ASR, and speech data is non-existent for the majority of African accents. We release AfriSpeech, 200hrs of Pan-African English speech, 67,577 clips from 2,463 unique speakers across 120 indigenous accents from 13 countries for clinical and general domain ASR, a benchmark test set, with publicly available pre-trained models with SOTA performance on the AfriSpeech benchmark.
The Future of Secular Law in Spain: A Model Based on the Evolution of Religiosity and Religious Influence on Law
Authors: Garciandía Igal David 
Published: December 2023

Abstract
This article analyzes how the evolution of religiosity will affect the secularity of Spanish law. In a liberal constitutional system such as that of Spain, the influence of religion on law is inevitable. The article proposes a model based on two variables: the increase or decrease of the religious population and the capacity and willingness of religions to influence secular law. The four possible resulting scenarios are religious aggrandizement (a growing religious population seeking to shape the law); religious secularization (a growing religious population with a worldview compatible with secularity); religious backlash (some religious minorities undermining the secularity of the law); and religious diminishment (a declining religious population losing its capacity or willingness to influence the law). The model demonstrates theoretically that inclusion policies do not necessarily lead to the Islamization of Spain. Ignoring religious issues can lead to the marginalization of a religious minority, which favors radicalization and non-acceptance of secularity.
Japanese Climate Litigation and the Development of Personal Rights
Authors: Nishikawa Yumeno Grace 
Published: December 2023

Abstract
Since climate change was recognised as a global concern, there has been a growing number of climate-related cases around the world. While the development of climate litigation in Japan is often overlooked in the academic literature, Japanese citizens in fact have instituted four lawsuits that all aim to stop the construction and operation of coal-fired power plants, as the use of coal in the power generation sector is primarily responsible for the total emissions of greenhouse gases in Japan. Accordingly, this article aims to introduce the recent climate-related cases and to show how human rights-based concepts are utilized with the intention of incorporating environmental claims. More specifically, the development of the concept of personal rights (Jinkaku-ken, 人格権) is discussed, primarily by examining the arguments made in the tort law-based climate cases.
Rights-Based Climate Litigation in South Africa and the Netherlands
Authors: Wadiwala Zunaida Moosa 
Published: December 2023

Abstract
Academic research into international climate change litigation has shown that the courts yield significant power in bringing about an awareness of climate impacts as well as firmly entrenching rights and responsibilities for claimants and defendants. In April 2022, the IPCC’s Sixth Assessment Report noted in some detail how climate litigation is shaping climate governance. This article considers these statements within the framework of how courts have drawn on fundamental constitutional rights even without an exclusive reliance on the right to a healthy environment within the jurisdiction of South African climate litigation. The objective of this study is to investigate this claim by analysing the available legal mechanisms in South Africa and what legal strategies have been used in climate litigation to determine how South African climate litigation has shaped climate governance in comparison to climate litigation from the Netherlands. The core analysis examines firstly what the litigation is seeking to achieve, secondly which legal mechanisms and avenues were relied upon and thirdly, how this resonates between different jurisdictions. The key results will contribute to an understanding of the contribution that South African and Dutch climate litigation lends to global climate governance, the extent to which litigation relies on entrenched fundamental rights; it further tracks how, if at all, transnational climate governance litigation has developed in this respect.
Teaching Constructive Replications in the Behavioral and Social Sciences Using Quantitative Data
Authors: Bauer Gerrit , Breznau Nate , Gereke Johanna , Höffler Jan H. , Janz Nicole , Rahal Rima-Maria , Rennstich Joachim K. , Soiné Hannah 
Published: December 2023

Introduction The replication crisis in the behavioral and social sciences spawned a credibility revolution, calling for new open science research practices that ensure greater transparency, including preregistrations, open data and code, and open access. Statement of the Problem Replications of published research are an important element in this revolution as part of the self-correcting process of scientific knowledge production; however, the teaching value of replications is still underutilized thus far. Literature Review Pedagogical knowledge points to the value of replication as critical to the scientific method of test and retest. Psychology has already begun mass efforts to reproduce previous experiments. Yet, we have very few examples of how analytical and reanalysis replications, after the data come in, contribute to the reproducibility crisis and can be integrated into undergraduate and graduate courses. Teaching Implications Replications with quantitative data can be a pedagogical tool for improving student research method skills and introducing them to best research practices via learning-by-doing. Conclusion This article aims to start filling this gap by offering guidance to instructors in designing and teaching replications for students at various levels and disciplines in the social and behavioral sciences, including a supplementary teaching companion.
Radiomics from multisite MRI and clinical data to predict clinically significant prostate cancer
Authors: Krauss Wolfgang , Frey Janusz , Heydorn Lagerlöf Jakob , Lidén Mats , Thunberg Per 
Published: December 2023

Background Magnetic resonance imaging (MRI) is useful in the diagnosis of clinically significant prostate cancer (csPCa). MRI-derived radiomics may support the diagnosis of csPCa. Purpose To investigate whether adding radiomics from biparametric MRI to predictive models based on clinical and MRI parameters improves the prediction of csPCa in a multisite-multivendor setting. Material and Methods Clinical information (PSA, PSA density, prostate volume, and age), MRI reviews (PI-RADS 2.1), and radiomics (histogram and texture features) were retrieved from prospectively included patients examined at different radiology departments and with different MRI systems, followed by MRI-ultrasound fusion guided biopsies of lesions PI-RADS 3–5. Predictive logistic regression models of csPCa (Gleason score ≥7) for the peripheral (PZ) and transition zone (TZ), including clinical data and PI-RADS only, and combined with radiomics, were built and compared using receiver operating characteristic (ROC) curves. Results In total, 456 lesions in 350 patients were analyzed. In PZ and TZ, PI-RADS 4-5 and PSA density, and age in PZ, were independent predictors of csPCa in models without radiomics. In models including radiomics, PI-RADS 4-5, PSA density, age, and ADC energy were independent predictors in PZ, and PI-RADS 5, PSA density and ADC mean in TZ. Comparison of areas under the ROC curve (AUC) for the models without radiomics (PZ: AUC = 0.82, TZ: AUC = 0.80) versus with radiomics (PZ: AUC = 0.82, TZ: AUC = 0.82) showed no significant differences (PZ: P = 0.366; TZ: P = 0.171). Conclusion PSA density and PI-RADS are potent predictors of csPCa. Radiomics do not add significant information to our multisite-multivendor dataset.
Impact of a Parent Education Program Delivered by Nurses and Health Care Providers in Reducing Infant Physical Abuse Hospitalization Rates in British Columbia, Canada
Authors: Sadler Karen , Rajabali Fahra , Zheng Alex , Jain Nita , Pike Ian 
Published: December 2023

BackgroundThe Period of PURPLE Crying Program® ( PURPLE) is a universal parent education program that is delivered by nurses and health care providers to all parents/caregivers of newborns in British Columbia (B.C.). The aim of the program is to reduce the incidence of Traumatic Head Injury -Child Maltreatment (THI-CM), a form of child physical abuse.ObjectiveTo determine if the PURPLE program had an impact on the rate of physical abuse hospitalizations for children less than or equal to 24 months of age in B.C. since implementation in 2009.MethodsThe analysis measured physical abuse hospitalization rates for the period January 1, 1999 to December 31, 2019 and excluded any cases of confirmed Traumatic Head Injury-Child Maltreatment. Data were divided into pre-implementation period January, 1999 to December, 2008, and post-implementation period January, 2009 to December, 2019. Data were obtained from the Discharge Abstract Database and B.C. THI-CM Surveillance System to capture information on infant child abuse. Poisson regression and ANCOVA was applied to model the change in rates pre and post program implementation.ResultsPhysical abuse hospitalization rates decreased by 30% post-implementation period (95% CI: −14%, 57%, p  =  0.1561). The decreasing linear trend in the post-implementation period was significantly different than the increasing linear trend in the pre-implementation period (F1,17  =  4.832, p  =  0.042).ConclusionsNurses’ role in engaging parents in conversations about PURPLE messages over multiple timepoints within a structured universal program model resulted in a decrease in physical abuse hospitalization rates since the implementation of PURPLE.
Artificial intelligence for triaging of breast cancer screening mammograms and workload reduction: A meta-analysis of a deep learning software
Authors: Xavier Debora , Miyawaki Isabele , Campello Jorge Carlos Alberto , Freitas Silva Gabriela Batalini , Lloyd Maxwell , Moraes Fabio , Patel Bhavika , Batalini Felipe 
Published: December 2023

Objective Deep learning (DL) has shown promising results for improving mammographic breast cancer diagnosis. However, the impact of artificial intelligence (AI) on the breast cancer screening process has not yet been fully elucidated in terms of potential workload reduction. We aim to assess if AI-based triaging of breast cancer screening mammograms could reduce the radiologist's workload with non-inferior sensitivity. Methods PubMed, EMBASE, Cochrane Central, and Web of Science databases were systematically searched for studies that evaluated AI algorithms on computer-aided triage of breast cancer screening mammograms. We extracted data from homogenous studies and performed a proportion meta-analysis with a random-effects model to examine the radiologist's workload reduction (proportion of low-risk mammograms that could be theoretically ruled out from human's assessment) and the software's sensitivity to breast cancer detection. Results Thirteen studies were selected for full review, and three studies that used the same commercially available DL algorithm were included in the meta-analysis. In the 156,852 examinations included, the threshold of 7 was identified as optimal. With these parameters, radiologist workload decreased by 68.3% (95%CI 0.655–0.711, I² = 98.76%, p < 0.001), while achieving a sensitivity of 93.1% (95%CI 0.882–0.979, I² = 83.86%, p = 0.002) and a specificity of 68.7% (95% CI 0.684–0.723, I² = 97.5%, p < 0.01). Conclusions The deployment of DL computer-aided triage of breast cancer screening mammograms reduces the radiology workload while maintaining high sensitivity. Although the implementation of AI remains complex and heterogeneous, it is a promising tool to optimize healthcare resources.
Effect of different HA/β-TCP coated 3D printed bioceramic scaffolds on repairing large bone defects in rabbits
Authors: Wen Jian , Song Meiling , Zeng Yu , Dong Xieping 
Published: December 2023

Background Treatment of large segmental bone defects is still a major clinical challenge, and bone grafting is the main method. The development of novel bone graft substitutes will help solve this problem. Methods Porous bioceramics hydroxyapatite (HA) scaffolds coated with different ratios of HA/β-tricalcium phosphate (β-TCP) were prepared by 3D printing. The scaffolds were sampled and tested in large segmental bone defect rabbit models. X-ray, micro-computed tomography (CT), hematoxylin and eosin (HE) staining, Van-Gieson staining, and type I collagen staining were performed to find the best scaffolds for large segmental bone defect treatment. Results The average length, diameter, compressive strength, and porosity of the bioceramics scaffolds were 15.05 ± 0.10 mm, 4.98 ± 0.06 mm, 11.11 ± 0.77 MPa, and 54.26 ± 5.38%, respectively. Postoperative lateral radiographs suggested the scaffold group got better bone healing and stability than the blank group. Micro-CT showed new bones grew into the scaffold from the two ends of the fracture along the scaffold and finally achieved bony union. The new bone volume around the scaffolds suggested the 3:7 HA/β-TCP-coated bioceramic scaffolds were more favorable for the healing of large segmental bone defects. The results of HE, Van-Gieson, and type I collagen staining also suggested more new bone formation in 3:7 HA/β-TCP-coated bioceramic scaffolds. Conclusion 3:7 HA/β-TCP-coated porous bioceramics scaffolds are more conducive to the repair of large bone defects in rabbits. The results of this study can provide some reference and theoretical support in this area.
Unpeeling the onion: Digital triage and monitoring of general practice, private psychiatry, and psychology
Authors: Allison Stephen , Bastiampillai Tarun , Kisely Stephen , Looi Jeffrey CL 
Published: December 2023

Objective The Australian federal government is considering a ‘digital front door’ to mental healthcare. The Brain and Mind Centre at the University of Sydney has published a discussion paper advocating that the government should adopt a comprehensive model of digital triage and monitoring (DTM) based on a government-funded initiative Project Synergy ($30 million). We critically examine the final report on Project Synergy, which is now available under a Freedom of Information request. Conclusion The DTM model is disruptive. Non-government organisations would replace general practitioners as care coordinators. Patients, private psychiatrists, and psychologists would be subjected to additional layers of administration, assessment, and digital compliance, which may decrease efficiency, and lengthen the duration of untreated illness. Only one patient was deemed eligible for DTM, however, during the 8-month regional trial of Project Synergy (recruitment rate = 1/500,000 across the region). Instead of an unproven DTM model, the proposed ‘digital front door’ to Australian mental healthcare should emphasise technology-enabled shared care (general practitioners and mental health professionals) for the treatment of moderate-to-severe illness.
Dietary Consumption on Glycemic Control Among Prediabetes: A Review of the Literature
Authors: Thipsawat Sopida 
Published: December 2023

Introduction Prediabetes is a condition that, if left unaddressed, can lead to various complications, such as neuropathy, retinopathy, and nephropathy. Among the critical factors contributing to the development of type 2 diabetes mellitus, dietary choices stand out as particularly significant. Objective Consequently, our objective is to examine the latest research findings concerning dietary consumption and its impact on glycemic control in individuals with prediabetes. Methods A literature review of randomized controlled trials was performed using databases such as PubMed, Scopus, and ScienceDirect with searches conducted from January 2019 to 2023. The primary reviewer assessed the quality of the selected studies for bias risk using the Joanna Briggs Institute critical appraisal method for randomized controlled trials. Initially, 975 articles were identified through the search, but after applying the inclusion criteria, only 9 articles were ultimately selected. Results The review found that a carrageenan-free diet, yogurt with Lactobacillus plantarum OLL2712, Allium hookeri extract (AHE), and delta-tocotrienol improve HbA1C levels. However, salmon, zinc supplement, and balanced deep-sea water were not effective on HbA1C. In addition, studies on the effectiveness of vitamin D in controlling blood glucose levels are inconsistent. Conclusion Nurses can enhance patient outcomes through collaborative efforts to create individualized dietary strategies. These strategies may encompass the adoption of a carrageenan-free diet, the inclusion of L plantarum OLL2712-enriched yogurt, the utilization of AHE, and the integration of delta-tocotrienol into the dietary plan. This approach is particularly applicable to ambulatory care nurses, health supervisors, and primary care providers.
Physiological responses of coriander (Coriandrum sativum L.) to exogenous 2,4-epibrassinolide at different concentrations
Authors: Xu Zhiqi , Huang Shuchao , Xie Yandong , Wang Shuya , Jin Ning , Jin Li , Tie Jianzhong , Meng Xin , Li Zhaozhuang , Lyu Jian , Yu Jihua 
Published: December 2023

Abstract
Background
Brassinolide, known as the seventh plant hormone, can improve the photosynthetic capacity of plants, promote plant growth and development, promote the formation of horticultural crop yield, improve the quality of horticultural crops, and also improve the ability of plants to resist biological and abiotic stresses.

Results
The effects of different concentrations of exogenously sprayed 2,4-epibrassinolide (EBR) on growth, physiological and photosynthetic characteristics of ‘All-round large leaf coriander’ were studied in substrate culture. The results showed that 0.05, 0.1, and 0.5 mg.L− 1 EBR promoted the growth of coriander and increased the aboveground fresh and dry weights, with 0.5 mg.L− 1 EBR having the most significant effect. Spraying 0.1 mg.L− 1 EBR increased the content of soluble sugars and protein of coriander leaves. Spraying 0.1 and 0.5 mg.L− 1 EBR significantly increased the chlorophyll content and photosynthetic parameters of coriander leaves, and 0.5 mg.L− 1 EBR also significantly increased the chlorophyll fluorescence parameters of coriander leaves. Spraying 0.5 mg.L− 1 EBR upregulated the expression of CsRbcS, CsFBPase, and CsAld. Correlation analysis showed that aboveground fresh weight under exogenous EBR treatment was significantly positively correlated with aboveground dry weight, plant height, Pn, Gs, Ci, and CsAld (P < 0.05), and soluble sugar content was significantly positively correlated with the number of leaves, Y(II), qP, and CsRbcS. The results of the principal component analysis (PCA) showed that there was a significant separation between the treatment and the control groups. Spraying 0.5 mg.L− 1 EBR can promote the growth of coriander, improve the quality of coriander leaves, and strengthen coriander leaf photosynthetic capacity. This study provides new insights into the promotion of coriander growth and development following the application of exogenous EBR.

Conclusion
Exogenous EBR treatment increased coriander plant height, leaf growth and aboveground dry weight, and enhanced photosynthesis. Exogenous spraying of 0.5 mg.L− 1 EBR had the most significant effect.