bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncolytic Peptide‐Nanoplatform Drives Oncoimmune Response and Reverses Adenosine‐Induced Immunosuppressive Tumor Microenvironment
Authors: Wu Ye , Lin Jia‐Yi , Zhou Yu‐Dong , Liu Hai‐Jun , Lu Sheng‐Xin , Zhang Xiao‐Kun , Guan Ying‐Yun , Nagle Dale G. , Zhang Wei‐Dong , Chen Hong‐Zhuan , Luan Xin 
Published: January 2024

AbstractThe application of oncolytic peptides has become a powerful approach to induce complete and long‐lasting remission in multiple types of carcinomas, as affirmed by the appearance of tumor‐associated antigens and adenosine triphosphate (ATP) in large quantities, which jumpstarts the cancer‐immunity cycle. However, the ATP breakdown product adenosine is a significant contributor to forming the immunosuppressive tumor microenvironment, which substantially weakens peptide‐driven oncolytic immunotherapy. In this study, a lipid‐coated micelle (CA@TLM) loaded with a stapled oncolytic peptide (PalAno) and an adenosine 2A receptor (A2AR) inhibitor (CPI‐444) is devised to enact tumor‐targeted oncolytic immunotherapy and to overcome adenosine‐mediated immune suppression simultaneously. The CA@TLM micelle accumulates in tumors with high efficiency, and the acidic tumor microenvironment prompts the rapid release of PalAno and CPI‐444. Subsequently, PalAno induces swift membrane lysis of tumor cells and the release of antigenic materials. Meanwhile, CPI‐444 blocks the activation of the immunosuppressive adenosine‐A2AR signaling pathway. This combined approach exhibits pronounced synergy at stalling tumor growth and metastasis in animal models for triple‐negative breast cancer and melanoma, providing a novel strategy for enhanced oncolytic immunotherapy.
Uncovering the Network Modifier for Highly Disordered Amorphous Li‐Garnet Glass‐Ceramics
Authors: Zhu Yuntong , Kennedy Ellis R. , Yasar Bengisu , Paik Haemin , Zhang Yaqian , Hood Zachary D. , Scott Mary , Rupp Jennifer L.M. 
Published: January 2024

AbstractHighly disordered amorphous Li7La3Zr2O12 (aLLZO) is a promising class of electrolyte separators and protective layers for hybrid or all‐solid‐state batteries due to its grain‐boundary‐free nature and wide electrochemical stability window. Unlike low‐entropy ionic glasses such as LixPOyNz (LiPON), these medium‐entropy non‐Zachariasen aLLZO phases offer a higher number of stable structure arrangements over a wide range of tunable synthesis temperatures, providing the potential to tune the LBU‐Li+ transport relation. It is revealed that lanthanum is the active “network modifier” for this new class of highly disordered Li+ conductors, whereas zirconium and lithium serve as “network formers”. Specifically, within the solubility limit of La in aLLZO, increasing the La concentration can result in longer bond distances between the first nearest neighbors of Zr─O and La─O within the same local building unit (LBU) and the second nearest neighbors of Zr─La across two adjacent network‐former and network‐modifier LBUs, suggesting a more disordered medium‐ and long‐range order structure in LLZO. These findings open new avenues for future designs of amorphous Li+ electrolytes and the selection of network‐modifier dopants. Moreover, the wide yet relatively low synthesis temperatures of these glass‐ceramics make them attractive candidates for low‐cost and more sustainable hybrid‐ or all‐solid‐state batteries for energy storage.
Dibromomethane Knitted Highly Porous Hyper‐Cross‐Linked Polymers for Efficient High‐Pressure Methane Storage
Authors: Yang Shoukun , Zhong Zicheng , Hu Jiarui , Wang Xiaoyan , Tan Bien 
Published: January 2024

AbstractHyper‐cross‐linked polymers (HCPs) with ultra‐high porosity, superior physicochemical stability, and excellent cost‐effectiveness are attractive candidates for methane storage. However, the construction of HCPs with BET surface areas exceeding 3000 m2 g−1 remains extremely challenging. In this work, a newly developed DBM‐knitting method with a slow‐knitting rate is employed to increase the cross‐linking degree, in which dichloromethane (DCM) is replaced by dibromomethane (DBM) as both solvent and electrophilic cross‐linker, resulting in highly porous and physicochemically stable HCPs. The BET surface areas of DBM‐knitted SHCPs‐Br are 44%–120% higher than that of DCM‐knitted SHCPs‐Cl using the same building blocks. Remarkably, SHCP‐3‐Br exhibits an unprecedentedly high porosity (SBET = 3120 m2 g−1) among reported HCPs, and shows a competitive volumetric 5–100 bar working methane capacity of 191 cm3 (STP) cm−3 at 273 K calculated by using real packing density, which outperforms sate‐of‐art metal‐organic framework (MOFs) at comparable conditions. This facile and versatile low‐knitting‐rate strategy enables effective improvement in the porosity of HCPs for porosity‐desired applications.
γ‐Ray Irradiation Significantly Enhances Capacitive Energy Storage Performance of Polymer Dielectric Films
Authors: Wang Yiwei , Bao Zhiwei , Ding Song , Jia Jiangheng , Dai Zhizhan , Li Yaoxin , Shen Shengchun , Chu Songchao , Yin Yuewei , Li Xiaoguang 
Published: January 2024

AbstractPolymer dielectric capacitors are fundamental in advanced electronics and power grids but suffer from low energy density, hindering miniaturization of compact electrical systems. It is shown that high‐energy and strong penetrating γ‐irradiation significantly enhances capacitive energy storage performance of polymer dielectrics. γ‐irradiated biaxially oriented polypropylene (BOPP) films exhibit an extraordinarily high energy density of 10.4 J cm−3 at 968 MV m−1 with an efficiency of 97.3%. In particular, an energy density of 4.06 J cm−3 with an ultrahigh efficiency of 98% is reliably maintained through 20 000 charge–discharge cycles under 600 MV m−1. At 125 °C, the γ‐irradiated BOPP film still delivers a high discharged energy density of 5.88 J cm−3 with an efficiency of 90% at 770 MV m−1. Substantial improvements are also achieved for γ‐irradiated cycloolefin copolymers at a high temperature of 150 °C, verifying the strategy generalizability. Experimental and theoretical analyses reveal that the excellent performance should be related to the γ‐irradiation induced polar functional groups with high electron affinity in the molecular chain, which offer deep energy traps to impede charge transport. This work provides a simple and generally applicable strategy for developing high‐performance polymer dielectrics.
Tailoring Built‐In Electric Field in a Self‐Assembled Zeolitic Imidazolate Framework/MXene Nanocomposites for Microwave Absorption
Authors: Gao Zhenguo , Iqbal Aamir , Hassan Tufail , Hui Shengchong , Wu Hongjing , Koo Chong Min 
Published: January 2024

AbstractHeterointerface engineering, which plays a pivotal role in developing advanced microwave‐absorbing materials, is employed to design zeolitic imidazolate framework (ZIF)–MXene nanocomposites. The ZIF–MXene composites are prepared by electrostatic self‐assembly of negatively charged titanium carbide MXene flakes and positively charged Co‐containing ZIF nanomaterials. This approach effectively creates abundant Mott–Schottky heterointerfaces exhibiting a robust built‐in electric field (BIEF) effect, as evidenced by experimental and theoretical analyses, leading to a notable attenuation of electromagnetic energy. Systematic manipulation of the BIEF‐exhibiting heterointerface, achieved through topological modulation of the ZIF, proficiently alters charge separation, facilitates electron migration, and ultimately enhances polarization relaxation loss, resulting in exceptional electromagnetic wave absorption performance (reflection lossRLmin= −47.35 dB and effective absorption bandwidthfE= 6.32 GHz). The present study demonstrates an innovative model system for elucidating the interfacial polarization mechanisms and pioneers a novel approach to developing functional materials with electromagnetic characteristics through spatial charge engineering.
Mechanically and Thermally Robust Gel Electrolytes Built from A Charged Double Helical Polymer
Authors: Yu Deyang , Min Jungki , Lin Feng , Madsen Louis A. 
Published: January 2024

AbstractPolymer electrolytes have received tremendous interest in the development of solid‐state batteries, but often fall short in one or more key properties required for practical applications. Herein, a rigid gel polymer electrolyte prepared by immobilizing a liquid mixture of a lithium salt and poly(ethylene glycol) dimethyl ether with only 8 wt% poly(2,2′‐disulfonyl‐4,4′‐benzidine terephthalamide) (PBDT) is reported. The high charge density and rigid double helical structure of PBDT lead to formation of a nanofibrillar structure that endows this electrolyte with stronger mechanical properties, wider temperature window, and higher battery rate capability compared to all other poly(ethylene oxide) (PEO)‐based electrolytes. The ion transport mechanism in this rigid polymer electrolyte is systematically studied using multiple complementary techniques. Li/LiFePO4 cells show excellent capacity retention over long‐term cycling, with thermal cycling reversibility between ambient temperature and elevated temperatures, demonstrating compelling potential for solid‐state batteries targeting fast charging at high temperatures and slower discharging at ambient temperature.
A Hybrid Pulsed Laser Deposition Approach to Grow Thin Films of Chalcogenides
Authors: Surendran Mythili , Singh Shantanu , Chen Huandong , Wu Claire , Avishai Amir , Shao Yu‐Tsun , Ravichandran Jayakanth 
Published: January 2024

AbstractVapor‐pressure mismatched materials such as transition metal chalcogenides have emerged as electronic, photonic, and quantum materials with scientific and technological importance. However, epitaxial growth of vapor‐pressure mismatched materials are challenging due to differences in the reactivity, sticking coefficient, and surface adatom mobility of the mismatched species constituting the material, especially sulfur containing compounds. Here, a novel approach is reported to grow chalcogenides—hybrid pulsed laser deposition—wherein an organosulfur precursor is used as a sulfur source in conjunction with pulsed laser deposition to regulate the stoichiometry of the deposited films. Epitaxial or textured thin films of sulfides with variety of structure and chemistry such as alkaline metal chalcogenides, main group chalcogenides, transition metal chalcogenides, and chalcogenide perovskites are demonstrated, and structural characterization reveal improvement in thin film crystallinity, and surface and interface roughness compared to the state‐of‐the‐art. The growth method can be broadened to other vapor‐pressure mismatched chalcogenides such as selenides and tellurides. This work opens up opportunities for broader epitaxial growth of chalcogenides, especially sulfide‐based thin film technological applications.
Topological Analysis and Structural Determination of 3D Covalent Organic Frameworks
Authors: Guo Zi'ang , Zhang Zeyue , Sun Junliang 
Published: January 2024

Abstract3D covalent organic frameworks (3D COFs) constitute a new type of crystalline materials that consist of a range of porous structures with numerous applications in the fields of adsorption, separation, and catalysis. However, because of the complexity of the three‐periodic net structure, it is desirable to develop a thorough structural comprehension, along with a means to precisely determine the actual structure. Indeed, such advancements would considerably contribute to the rational design and application of 3D COFs. In this review, the reported topologies of 3D COFs are introduced and categorized according to the configurations of their building blocks, and a comprehensive overview of diffraction‐based structural determination methods is provided. The current challenges and future prospects for these materials will also be discussed.
Multiple Cations Nanoconfinement in Ultrathin V2O5 Nanosheets Enables Ultrafast Ion Diffusion Kinetics Toward High‐performance Zinc Ion Battery
Authors: Liu Yang , Lu Chengjie , Yang Yunting , Chen Wenshu , Ye Fei , Dong Hongliang , Wu Yuping , Ma Renzhi , Hu Linfeng 
Published: January 2024

AbstractNanoconfinement of cations in layered oxide cathode is an important approach to realize advanced zinc ion storage performance. However, thus far, the conventional hydrothermal/solvothermal route for this nanoconfinement has been restricted to its uncontrollable phase structure and the difficulty on the multiple cation co‐confinement simultaneously. Herein, this work reports a general, supramolecular self‐assembly of ultrathin V2O5 nanosheets using various unitary cations including Na+, K+, Mg2+, Ca2+, Zn2+, Al3+, NH4+, and multiple cations (NH4+ + Na+, NH4+ + Na+ + Ca2+, NH4+ + Na+ + Ca2+ +Mg2+). The unitary cation confinement results in a remarkable increase in the specific capacity and Zn‐ion diffusion kinetics, and the multiple cation confinement gives rise to superior structural and cycling stability by multiple cation synergetic pillaring effect. The optimized diffusion coefficient of Zn‐ion (7.5 × 10−8 cm2 s−1) in this assembly series surpasses most of the V‐based cathodes reported up to date. The work develops a novel multiple‐cations nanoconfinement strategy toward high‐performance cathode for aqueous battery. It also provides new insights into the guest cation regulation of zinc‐ion diffusion kinetics through a general, supramolecular assembly pathway.
Eco‐Friendly Materials for a Zero E‐Waste Society: Challenges and Opportunities in Engineering Plastics
Authors: Lee Seunghyeon , Huang Minhu , Lee Junhyuk , Choi Howon , Jo Il‐Young , Na Hyeonjun , Lee Yongjin , Youk Ji Ho , Yoon Myung‐Han , Shim Bong Sup 
Published: January 2024

AbstractThis review addresses the environmental challenges arising from the proliferation of plastic and electronic waste (E‐waste), driven by global economic and demographic expansion. Since the 1950s, the mass production of plastics has seriously threatened global sustainability, lacking effective post‐use management. E‐waste worsens the issue due to low recyclability and high toxicity. Resolving this requires improving biodegradability. The paper explores eco‐friendly biodegradable materials for a zero‐e‐waste society, focusing on multifunctional plastics in electronics, providing a comprehensive guide to material selection, and illustrating novel concepts through recent trials. The goal is fully biodegradable electronics, but transitioning from conventional material systems is complex. Notably, rendering engineering plastics in electronics biodegradable surpasses simply substituting conventional plastics. Thus, it is delved into various research initiatives focused on biodegradable materials for electronics, highlighting a systematic approach toward creating a fully integrated, biodegradable electronic system. This includes exploring the mechanisms of biodegradation and the integration of printed circuit boards (PCBs), a critical component in electronics. Achieving this represents a challenging but promising step toward a sustainable electronic future.
Oxidative Stress Promotes Liver Cancer Metastasis via RNF25‐Mediated E‐Cadherin Protein Degradation
Authors: Huang Zhao , Zhou Li , Duan Jiufei , Qin Siyuan , Jiang Jingwen , Chen Haining , Wang Kui , Liu Rui , Yuan Minlan , Tang Xiangdong , Nice Edouard C. , Wei Yuquan , Zhang Wei , Huang Canhua 
Published: January 2024

AbstractLoss of E‐cadherin (ECAD) is required in tumor metastasis. Protein degradation of ECAD in response to oxidative stress is found in metastasis of hepatocellular carcinoma (HCC) and is independent of transcriptional repression as usually known. Mechanistically, protein kinase A (PKA) senses oxidative stress by redox modification in its β catalytic subunit (PRKACB) at Cys200 and Cys344. The activation of PKA kinase activity subsequently induces RNF25 phosphorylation at Ser450 to initiate RNF25‐catalyzed degradation of ECAD. Functionally, RNF25 repression induces ECAD protein expression and inhibits HCC metastasis in vitro and in vivo. Altogether, these results indicate that RNF25 is a critical regulator of ECAD protein turnover, and PKA is a necessary redox sensor to enable this process. This study provides some mechanistic insight into how oxidative stress‐induced ECAD degradation promotes tumor metastasis of HCC.
MiR‐17‐5p‐engineered sEVs Encapsulated in GelMA Hydrogel Facilitated Diabetic Wound Healing by Targeting PTEN and p21
Authors: Wei Qian , Su Jianlong , Meng Sheng , Wang Yaxi , Ma Kui , Li Bingmin , Chu Ziqiang , Huang Qilin , Hu Wenzhi , Wang Zihao , Tian Lige , Liu Xi , Li Tanshi , Fu Xiaobing , Zhang Cuiping 
Published: January 2024

AbstractDelayed wound healing is a major complication of diabetes, and is associated with impaired cellular functions. Current treatments are unsatisfactory. Based on the previous reports on microRNA expression in small extracellular vesicles (sEVs), miR‐17‐5p‐engineered sEVs (sEVs17‐OE) and encapsulated them in gelatin methacryloyl (GelMA) hydrogel for diabetic wounds treatment are fabricated. SEVs17‐OE are successfully fabricated with a 16‐fold increase in miR‐17‐5p expression. SEVs17‐OE inhibited senescence and promoted the proliferation, migration, and tube formation of high glucose‐induced human umbilical vein endothelial cells (HG‐HUVECs). Additionally, sEVs17‐OE also performs a promotive effect on high glucose‐induced human dermal fibroblasts (HG‐HDFs). Mechanism analysis showed the expressions of p21 and phosphatase and tensin homolog (PTEN), as the target genes of miR‐17‐5p, are downregulated significantly by sEVs17‐OE. Accordingly, the downstream genes and pathways of p21 and PTEN, are activated. Next, sEVs17‐OE are loaded in GelMA hydrogel to fabricate a novel bioactive wound dressing and to evaluate their effects on diabetic wound healing. Gel‐sEVs17‐OE effectively accelerated wound healing by promoting angiogenesis and collagen deposition. The cellular mechanism may be associated with local cell proliferation. Therefore, a novel bioactive wound dressing by loading sEVs17‐OE in GelMA hydrogel, offering an option for chronic wound management is successfully fabricated.
Polyanionic Cathode Materials: A Comparison Between Na‐Ion and K‐Ion Batteries
Authors: Huang Hanjiao , Wu Xiaowei , Gao Yanjun , Li Zongyou , Wang Wei , Dong Wenshuai , Song Qingyi , Gan Songjie , Zhang Jianguo , Yu Qiyao 
Published: January 2024

AbstractSodium‐ion batteries (SIBs) and potassium‐ion batteries (PIBs) are considered the next‐generation candidates for future energy storage systems to partially substitute commercial lithium‐ion batteries because of their abundant sodium/potassium reserves, cost‐effectiveness, and high safety. Polyanionic cathode materials are widely used in alkali ion batteries due to their stable structural framework, high thermal stability, excellent alkali ion diffusion kinetics, and adjustable working voltage. Generally, the polyanionic cathodes used for SIBs surpass PIBs in the aspect of energy density and cycle life in most cases, however, the PIBs also have their unique advantages that are seldom reported. To this end, the polyanionic materials are classified by the valence states of active metal sites, the storage mechanism of Na+ and K+ in different crystal structures is summarized, and the electrochemical performance between SIBs and PIBs is compared. Particularly, some unique advantages of polyanionic cathodes in PIBs, such as high working voltage, superior rate capability, and excellent capacity retention are revealed, and the possible reasons are discussed in detail. Finally, various viable solutions are proposed to improve the battery performance of polyanionic compounds for future development.
Zinc (II) complexes with Schiff bases obtained from N‐[2‐(cyclohexyliminomethyl)‐ or 2‐(4‐cyclohexylphenyliminomethyl) phenyl]‐4‐methylbenzenesulfonamides and their application as highly luminescent blue emitters for OLEDs
Authors: Burlov Anatolii S. , Koshchienko Yurii V. , Vlasenko Valery G. , Demidov Oleg P. , Chaltsev Bogdan V. , Kiskin Mikhail A. , Garnovskii Dmitrii A. , Kolodina Alexandra A. , Gusev Alexey N. , Braga Elena V. , Nauhatsky Igor A. , Linert Wolfgang 
Published: January 2024

Two new Schiff base compounds of N‐{2‐[(E)‐сyclohexyliminomethyl]phenyl}‐4‐methylbenzenesulfonamide, N‐{2‐[(E)‐(4‐сyclohexylphenyl)iminomethyl]phenyl}‐4‐methylbenzenesulfonamide and their Zn(II) complexes have been synthesized and characterized by elemental analysis, FT‐IR and UV–Vis spectra, and single crystal X‐ray determination. In both complexes, Zn2+ ions have a tetrahedral environment with two nitrogen atoms of the tosylamide groups and two nitrogen atoms of the imine fragment. Time‐dependent density functional theory calculations have been performed on two zinc(II) complexes in order to assign their experimental UV–visible absorption bands. Zinc(II) complexes showed thermal stability up to 335–340°C under a nitrogen atmosphere by thermogravimetric analysis (TGA). The photoluminescent spectra show that both Zn(II) complexes in the solid state at room temperature emit blue luminescence with high emission quantum yields of 20% and 29%. The doped devices with configurations of indium tin oxide (ITO)/poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/N,N′‐Di(1‐naphthyl)‐N,N′‐diphenyl‐(1,1′‐biphenyl)‐4,4′‐diamine (NPD)/4,4′‐N,N′ ‐dicarbazolebiphenyl (CBP):Zinc(II) complex (5%)/1,3,5‐tris(N‐phenylbenzimidazole‐2‐yl) benzene (TPBI)/LiF/Al have been fabricated and investigated. The doped device based on the complex with the сyclohexylphenyl substituent of the ligand showed the best electroluminescent characteristics with maximum brightness Lmax of 3415 cd/m2, maximum current efficiency of 2.8 cd/A, and power efficiency of 1.9 lm/W, while the doped device with emitter on the base of the complex with the сyclohexyl substituent showed slightly worse electroluminescence (EL) performance with Lmax of 2105 cd/m2, maximum current efficiency of 2.1 cd/A, and power efficiency of 1.6 lm/W.
Crystal Engineering and Self‐Assembled Nanoring Formation with Purine‐CdII/HgII Supramolecular Frameworks
Authors: Avasthi Ilesha , Muthukumaran R. , Prajapati Rajneesh K. , Sankararamakrishnan Ramasubbu , Verma Sandeep 
Published: January 2024

AbstractWe report three complexes of CdII and HgII with two purine rare tautomers, N9‐(pyridin‐2‐ylmethyl)‐N6‐methoxyadenine, L1 and N7‐(pyridin‐2‐ylmethyl)‐N6‐methoxyadenine, L2, highlighting diverse crystallographic signatures exhibited by them. Influence of substituents, binding sites, steric effects and metal salts on the different modes of binding enabled an insight into metal‐nucleobase interactions. L1 interacted with two and three equivalents of Cd(NO3)2.4H2O and HgCl2, respectively, while L2 interacted with two equivalents of HgCl2, altogether leading to three different complexes (1 [C48H48Cd6N34O50], 2 [C12H12Cl4Hg2N6O] and 3 [C12H12Cl2HgN6O]) possessing varied dimensionality and stabilising interactions. The photoluminescent properties of these coordination frameworks have also been probed. Notably, nanoring‐like structures were obtained, as a result of self‐assembly of 3 when investigated by transmission electron microscopy, additionally supported by molecular dynamics simulations.