bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signals of discipline and puritanical challenges to liberty
Authors: Celniker Jared B. , Ditto Peter H. , Piff Paul K. , Shariff Azim F. 
Published: October 2023

Abstract
We extend the target authors' moral disciplining theory (MDT) by discussing signaling, proscriptive and prescriptive morality, and the dynamics by which signaling may operate in tandem with proscriptive and prescriptive forms of moral disciplining. We also suggest that MDT can help explain challenges to economic and social progress by revealing fundamental tensions between puritanical intuitions and liberal ideals.
The evolution of puritanical morality has not always served to strengthen cooperation, but to reinforce male dominance and exclude women
Authors: Szocik Konrad 
Published: October 2023

Abstract
Puritanical morality regulates a range of seemingly insignificant behaviors, including those involving human sexuality. A sizable portion of the latter particularly burdens women, who are held responsible for the moral conduct of men. In my paper, I show that these norms have not necessarily served to evolve cooperation, but to subjugate and eliminate women from public life.
Puritanical morality and the scaffolded evolution of self-control
Authors: Veit Walter , Browning Heather 
Published: October 2023

Abstract
There is a puzzle in reconciling the widespread presence of puritanical norms condemning harmless pleasures with the theory that morality evolved to reap the benefits of cooperation. Here, we draw on the work of several philosophers to support the argument by Fitouchi et al. that these norms evolved to facilitate and scaffold self-control for the sake of cooperation.
As the crow flies: tracking policy diffusion through stakeholder networks
Authors: Mistur Evan M. , Matisoff Daniel C. 
Published: October 2023

AbstractPolicy diffusion is an important element of the policy formation process. However, understanding of the micro-level interactions governing policy spread remains limited. Much of the literature focuses on macro-level proxies for intergovernmental connectivity. These proxies outline broad diffusion patterns without specifying the micro-level mechanisms that govern how individuals facilitate that diffusion. The role of stakeholders in diffusion in the policy subsystem is also poorly understood. We construct a panel dataset covering the spread of the US ecotourism programs from 1993 to 2016 to investigate how micro-level movement within stakeholder networks explains state-level policy diffusion over time. Using fixed-effects regression, we find that stakeholder movement significantly drives diffusion, acting as a mechanism of knowledge transfer. Our findings provide a more precise theoretical understanding of how policy knowledge diffuses at the micro level, empirically explain the role of policy stakeholders in diffusion, and highlight the value of citizen-science data for policy research.
Descending aortic translocation for left aortic arch with right descending aorta and coarctation of the aorta
Authors: Lee Cheul , Lee Won Young , Shin Ju Ae , Lee Jae Young 
Published: October 2023

AbstractLeft aortic arch with right descending aorta associated with coarctation of the aorta is a rare congenital cardiac anomaly. Conventional aortic arch repair in this condition may cause airway compression by the abnormally coursing descending aorta. We present the case of a neonate with this anomaly who underwent successful descending aortic translocation to prevent postoperative left main bronchial stenosis.
How Long Do Runoff‐Generated Debris‐Flow Hazards Persist After Wildfire?
Authors: Graber Andrew P. , Thomas Matthew A. , Kean Jason W. 
Published: October 2023

AbstractRunoff‐generated debris flows are a potentially destructive and deadly response to wildfire until sufficient vegetation and soil‐hydraulic recovery have reduced susceptibility to the hazard. Elevated debris‐flow susceptibility may persist for several years, but the controls on the timespan of the susceptible period are poorly understood. To evaluate the connection between vegetation recovery and debris‐flow occurrence, we calculated recovery for 25 fires in the western United States using satellite‐derived leaf area index (LAI) and compared recovery estimates to the timing of 536 debris flows from the same fires. We found that the majority (>98%) of flows occurred when LAI was less than 2/3 of typical prefire values. Our results show that total vegetation recovery is not necessary to inhibit runoff‐generated flows in a wide variety of regions in the western United States. Satellite‐derived vegetation data show promise for estimating the timespan of debris‐flow susceptibility.
Simulating Atmospheric Dust With a Global Variable‐Resolution Model: Model Description and Impacts of Mesh Refinement
Authors: Feng Jiawang , Zhao Chun , Du Qiuyan , Xu Mingyue , Gu Jun , Hu Zhiyuan , Chen Yu 
Published: October 2023

AbstractIn this study, a global variable‐resolution modeling framework of atmospheric dust and its radiative feedback is established and evaluated. In this model, atmospheric dust is simulated simultaneously with meteorological fields, and dust‐radiation interactions are included. Five configurations of global mesh with refinement at different resolutions and over different regions are used to explore the impacts of regional refinement on modeling dust lifecycle at regional and global scales. The model reasonably produces the overall magnitudes and spatial variabilities of global dust metrics such as surface mass concentration, deposition, aerosol optical depth, and radiative forcing compared to observations and previous modeling results. Two global variable‐resolution simulations with mesh refinement over major deserts of North Africa (V16 km‐NA) and East Asia (V16 km‐EA) simulate less dust emissions and smaller dry deposition rates inside the refined regions due to the weakened near‐surface wind speed caused by better resolved topographic complexity at higher resolution. The dust mass loadings over North Africa are close to each other between V16 km‐NA and the quasi‐uniform resolution (∼120 km) (U120 km), while over East Asia, V16 km‐EA simulates higher dust mass loading. Over the non‐refined areas with the same resolution, the difference between global variable‐resolution and uniform‐resolution experiments also exists, which is partly related to their difference in dynamic time‐step and the coefficient for horizontal diffusion. Refinement at convection‐permitting resolution around the Tibetan Plateau (TP) simulates less dust due to its more efficient wet scavenging from resolved convective precipitation around the TP against coarse resolution.
Whole-infrared-band camouflage with dual-band radiative heat dissipation
Authors: Qin Bing , Zhu Yining , Zhou Yiwei , Qiu Min , Li Qiang 
Published: October 2023

AbstractAdvanced multispectral detection technologies have emerged as a significant threat to objects, necessitating the use of multiband camouflage. However, achieving effective camouflage and thermal management across the entire infrared spectrum, especially the short-wave infrared (SWIR) band, remains challenging. This paper proposes a multilayer wavelength-selective emitter that achieves effective camouflage across the entire infrared spectrum, including the near-infrared (NIR), SWIR, mid-wave infrared (MWIR), and long-wave infrared (LWIR) bands, as well as the visible (VIS) band. Furthermore, the emitter enables radiative heat dissipation in two non-atmospheric windows (2.5–3 μm and 5–8 μm). The emitter’s properties are characterized by low emittance of 0.270/0.042/0.218 in the SWIR/MWIR/LWIR bands, and low reflectance of 0.129/0.281 in the VIS/NIR bands. Moreover, the high emittance of 0.742/0.473 in the two non-atmospheric windows ensures efficient radiative heat dissipation, which results in a temperature decrement of 14.4 °C compared to the Cr reference at 2000 W m−2 input power density. This work highlights the role of solar radiance in camouflage, and provides a comprehensive guideline for developing multiband camouflage compatible with radiative heat dissipation, from the visible to LWIR.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Authors: Zhao Chen , Liang Fangte , Ye Mengling , Wu Siyi , Qin Yi , Zhao Lu , Zhang Lu , He Jing , Cen Liming , Lin Fei 
Published: October 2023

AbstractLung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into the lungs. Neutrophil extracellular traps (NETs) have been suggested to exert a critical role in the pathogenesis of inflammation and infection in humans and animals, while the exact functions and underlying mechanisms of NETs in LIRI remain insufficiently elucidated. In this study, we investigated the role of pore-forming protein gasdermin D (GSDMD) on NETs release in LIRI induced by lung ischemia/reperfusion (I/R). We found that disulfiram, a GSDMD inhibitor, dramatically reduced NETs release and pathological injury in lung I/R in vivo and in vitro. Additionally, GSDMD caused mitochondrial DNA (mtDNA) leaking into the neutrophil cytosol, and then the cytoplasmic mtDNA activated the cGAS-STING signaling pathway and stimulated NETs formation in lung I/R. Furthermore, inhibition of cGAS/STING pathway could inhibit cytosol mtDNA mediated NETs formation.
Strain control of a bandwidth-driven spin reorientation in Ca3Ru2O7
Authors: Dashwood C. D. , Walker A. H. , Kwasigroch M. P. , Veiga L. S. I. , Faure Q. , Vale J. G. , Porter D. G. , Manuel P. , Khalyavin D. D. , Orlandi F. , Colin C. V. , Fabelo O. , Krüger F. , Perry R. S. , Johnson R. D. , Green A. G. , McMorrow D. F. 
Published: October 2023

AbstractThe layered-ruthenate family of materials possess an intricate interplay of structural, electronic and magnetic degrees of freedom that yields a plethora of delicately balanced ground states. This is exemplified by Ca3Ru2O7, which hosts a coupled transition in which the lattice parameters jump, the Fermi surface partially gaps and the spins undergo a 90∘ in-plane reorientation. Here, we show how the transition is driven by a lattice strain that tunes the electronic bandwidth. We apply uniaxial stress to single crystals of Ca3Ru2O7, using neutron and resonant x-ray scattering to simultaneously probe the structural and magnetic responses. These measurements demonstrate that the transition can be driven by externally induced strain, stimulating the development of a theoretical model in which an internal strain is generated self-consistently to lower the electronic energy. We understand the strain to act by modifying tilts and rotations of the RuO6 octahedra, which directly influences the nearest-neighbour hopping. Our results offer a blueprint for uncovering the driving force behind coupled phase transitions, as well as a route to controlling them.
Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Authors: Chongsaritsinsuk Joann , Steigmeyer Alexandra D. , Mahoney Keira E. , Rosenfeld Mia A. , Lucas Taryn M. , Smith Courtney M. , Li Alice , Ince Deniz , Kearns Fiona L. , Battison Alexandria S. , Hollenhorst Marie A. , Judy Shon D. , Tiemeyer Katherine H. , Attah Victor , Kwon Catherine , Bertozzi Carolyn R. , Ferracane Michael J. , Lemmon Mark A. , Amaro Rommie E. , Malaker Stacy A. 
Published: October 2023

AbstractMucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells and act as key regulators in cellular immunity. However, their dense O-glycosylation remains enigmatic, primarily due to the challenges associated with studying mucin domains. Here, we demonstrate that the mucinase SmE has a unique ability to cleave at residues bearing very complex glycans. SmE enables improved mass spectrometric analysis of several mucins, including the entire TIM family. With this information in-hand, we perform molecular dynamics (MD) simulations of TIM-3 and -4 to understand how glycosylation affects structural features of these proteins. Finally, we use these models to investigate the functional relevance of glycosylation for TIM-3 function and ligand binding. Overall, we present a powerful workflow to better understand the detailed molecular structures and functions of the mucinome.
Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma
Authors: Bao Chunyang , Tourdot Richard W. , Brunette Gregory J. , Stewart Chip , Sun Lili , Baba Hideo , Watanabe Masayuki , Agoston Agoston T. , Jajoo Kunal , Davison Jon M. , Nason Katie S. , Getz Gad , Wang Kenneth K. , Imamura Yu , Odze Robert , Bass Adam J. , Stachler Matthew D. , Zhang Cheng-Zhong 
Published: October 2023

AbstractThe progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood. Here we perform haplotype-specific analysis of chromosomal copy-number evolution in the progression of Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC) on multiregional whole-genome sequencing data of BE with dysplasia and microscopic EAC foci. We identify distinct patterns of copy-number evolution indicating multigenerational chromosomal instability that is initiated by cell division errors but propagated only after p53 loss. While abnormal mitosis, including whole-genome duplication, underlies chromosomal copy-number changes, segmental alterations display signatures of successive breakage-fusion-bridge cycles and chromothripsis of unstable dicentric chromosomes. Our analysis elucidates how multigenerational chromosomal instability generates copy-number variation in BE cells, precipitates complex alterations including DNA amplifications, and promotes their independent clonal expansion and transformation. In particular, we suggest sloping copy-number variation as a signature of ongoing chromosomal instability that precedes copy-number complexity. These findings suggest copy-number heterogeneity in advanced cancers originates from chromosomal instability in precancerous cells and such instability may be identified from the presence of sloping copy-number variation in bulk sequencing data.
Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
Authors: Xue Jing , Zeng Weizhong , Han Yan , John Scott , Ottolia Michela , Jiang Youxing 
Published: October 2023

AbstractNa+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+. They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ homeostasis. Although extensively studied, little is known about the global structural arrangement of eukaryotic NCXs and the structural mechanisms underlying their regulation by various cellular cues including cytosolic Na+ and Ca2+. Here we present the cryo-EM structures of human cardiac NCX1 in both inactivated and activated states, elucidating key structural elements important for NCX ion exchange function and its modulation by cytosolic Ca2+ and Na+. We demonstrate that the interactions between the ion-transporting transmembrane (TM) domain and the cytosolic regulatory domain define the activity of NCX. In the inward-facing state with low cytosolic [Ca2+], a TM-associated four-stranded β-hub mediates a tight packing between the TM and cytosolic domains, resulting in the formation of a stable inactivation assembly that blocks the TM movement required for ion exchange function. Ca2+ binding to the cytosolic second Ca2+-binding domain (CBD2) disrupts this inactivation assembly which releases its constraint on the TM domain, yielding an active exchanger. Thus, the current NCX1 structures provide an essential framework for the mechanistic understanding of the ion transport and cellular regulation of NCX family proteins.
TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
Authors: Heyes Elizabeth , Wilhelmson Anna S. , Wenzel Anne , Manhart Gabriele , Eder Thomas , Schuster Mikkel B. , Rzepa Edwin , Pundhir Sachin , D’Altri Teresa , Frank Anne-Katrine , Gentil Coline , Woessmann Jakob , Schoof Erwin M. , Meggendorfer Manja , Schwaller Jürg , Haferlach Torsten , Grebien Florian , Porse Bo T. 
Published: October 2023

AbstractThe myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPADM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPANT), promoting expression of the leukemia-associated p30 isoform, and amorphic C-terminal mutations. The most frequently co-mutated genes in CEBPADM AML are GATA2 and TET2, however the molecular mechanisms underlying this co-mutational spectrum are incomplete. By combining transcriptomic and epigenomic analyses of CEBPA-TET2 co-mutated patients with models thereof, we identify GATA2 as a conserved target of the CEBPA-TET2 mutational axis, providing a rationale for the mutational spectra in CEBPADM AML. Elevated CEBPA levels, driven by CEBPANT, mediate recruitment of TET2 to the Gata2 distal hematopoietic enhancer thereby increasing Gata2 expression. Concurrent loss of TET2 in CEBPADM AML induces a competitive advantage by increasing Gata2 promoter methylation, thereby rebalancing GATA2 levels. Of clinical relevance, demethylating treatment of Cebpa-Tet2 co-mutated AML restores Gata2 levels and prolongs disease latency.
Metal to non-metal sites of metallic sulfides switching products from CO to CH4 for photocatalytic CO2 reduction
Authors: Chai Yao , Kong Yuehua , Lin Min , Lin Wei , Shen Jinni , Long Jinlin , Yuan Rusheng , Dai Wenxin , Wang Xuxu , Zhang Zizhong 
Published: October 2023

AbstractThe active center for the adsorption and activation of carbon dioxide plays a vital role in the conversion and product selectivity of photocatalytic CO2 reduction. Here, we find multiple metal sulfides CuInSnS4 octahedral nanocrystal with exposed (1 1 1) plane for the selectively photocatalytic CO2 reduction to methane. Still, the product is switched to carbon monoxide on the corresponding individual metal sulfides In2S3, SnS2, and Cu2S. Unlike the common metal or defects as active sites, the non-metal sulfur atom in CuInSnS4 is revealed to be the adsorption center for responding to the selectivity of CH4 products. The carbon atom of CO2 adsorbed on the electron-poor sulfur atom of CuInSnS4 is favorable for stabilizing the intermediates and thus promotes the conversion of CO2 to CH4. Both the activity and selectivity of CH4 products over the pristine CuInSnS4 nanocrystal can be further improved by the modification of with various co-catalysts to enhance the separation of the photogenerated charge carrier. This work provides a non-metal active site to determine the conversion and selectivity of photocatalytic CO2 reduction.
Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis
Authors: Li Guanqun , Liu Liwei , Lu Tianqi , Sui Yuhang , Zhang Can , Wang Yongwei , Zhang Tao , Xie Yu , Xiao Peng , Zhao Zhongjie , Cheng Chundong , Hu Jisheng , Chen Hongze , Xue Dongbo , Chen Hua , Wang Gang , Kong Rui , Tan Hongtao , Bai Xuewei , Li Zhibo , McAllister Florencia , Li Le , Sun Bei 
Published: October 2023

AbstractHypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in HTGP and the mechanism remains unclear. Here, we observe lower diversity of gut microbiota and absence of beneficial bacteria in HTGP patients. In a fecal microbiota transplantation mouse model, the colonization of gut microbiota from HTGP patients recruits neutrophils and increases neutrophil extracellular traps (NETs) formation that exacerbates pancreatic injury and systemic inflammation. We find that decreased abundance of Bacteroides uniformis in gut microbiota impairs taurine production and increases IL-17 release in colon that triggers NETs formation. Moreover, Bacteroides uniformis or taurine inhibits the activation of NF-κB and IL-17 signaling pathways in neutrophils which harness NETs and alleviate pancreatic injury. Our findings establish roles of endogenous Bacteroides uniformis-derived metabolic and inflammatory products on suppressing NETs release, which provides potential insights of ameliorating HTGP through gut microbiota modulation.
Inverse design of chiral functional films by a robotic AI-guided system
Authors: Xie Yifan , Feng Shuo , Deng Linxiao , Cai Aoran , Gan Liyu , Jiang Zifan , Yang Peng , Ye Guilin , Liu Zaiqing , Wen Li , Zhu Qing , Zhang Wanjun , Zhang Zhanpeng , Li Jiahe , Feng Zeyu , Zhang Chutian , Du Wenjie , Xu Lixin , Jiang Jun , Chen Xin , Zou Gang 
Published: October 2023

AbstractArtificial chiral materials and nanostructures with strong and tuneable chiroptical activities, including sign, magnitude, and wavelength distribution, are useful owing to their potential applications in chiral sensing, enantioselective catalysis, and chiroptical devices. Thus, the inverse design and customized manufacturing of these materials is highly desirable. Here, we use an artificial intelligence (AI) guided robotic chemist to accurately predict chiroptical activities from the experimental absorption spectra and structure/process parameters, and generate chiral films with targeted chiroptical activities across the full visible spectrum. The robotic AI-chemist carries out the entire process, including chiral film construction, characterization, and testing. A machine learned reverse design model using spectrum embedded descriptors is developed to predict optimal structure/process parameters for any targeted chiroptical property. A series of chiral films with a dissymmetry factor as high as 1.9 (gabs ~ 1.9) are identified out of more than 100 million possible structures, and their feasible application in circular polarization-selective color filters for multiplex laser display and switchable circularly polarized (CP) luminescence is demonstrated. Our findings not only provide chiral films with the highest reported chiroptical activity, but also have great fundamental value for the inverse design of chiroptical materials.
Signature of spin-phonon coupling driven charge density wave in a kagome magnet
Authors: Miao H. , Zhang T. T. , Li H. X. , Fabbris G. , Said A. H. , Tartaglia R. , Yilmaz T. , Vescovo E. , Yin J.-X. , Murakami S. , Feng X. L. , Jiang K. , Wu X. L. , Wang A. F. , Okamoto S. , Wang Y. L. , Lee H. N. 
Published: October 2023

AbstractThe intertwining between spin, charge, and lattice degrees of freedom can give rise to unusual macroscopic quantum states, including high-temperature superconductivity and quantum anomalous Hall effects. Recently, a charge density wave (CDW) has been observed in the kagome antiferromagnet FeGe, indicative of possible intertwining physics. An outstanding question is that whether magnetic correlation is fundamental for the spontaneous spatial symmetry breaking orders. Here, utilizing elastic and high-resolution inelastic x-ray scattering, we observe a c-axis superlattice vector that coexists with the 2$$\times$$
×
2$$\times$$
×
1 CDW vectors in the kagome plane. Most interestingly, between the magnetic and CDW transition temperatures, the phonon dynamical structure factor shows a giant phonon-energy hardening and a substantial phonon linewidth broadening near the c-axis wavevectors, both signaling the spin-phonon coupling. By first principles and model calculations, we show that both the static spin polarization and dynamic spin excitations intertwine with the phonon to drive the spatial symmetry breaking in FeGe.