bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a human-size magnetic particle imaging device for sentinel lymph node biopsy of breast cancer
Authors: Bai Shi , Gai Lingke , Zhang Qinyang , Kang Yue , Liu Zhiyao , He Yuan , Liu Wenzhong , Jiang Tao , Du Zhongzhou , Du Siyao , Gao Si , Zhang Min , Li Tianshu 
Published: February 2024

In this study, a novel human-size handheld magnetic particle imaging (MPI) system was developed for the high-precision detection of sentinel lymph nodes for breast cancer. The system consisted of a highly sensitive home-made MPI detection probe, a set of concentric coils pair for spatialization, a solenoid coil for uniform excitation at 8 kHz@1.5 mT, and a full mirrored coil set positioned far away from the scanning area. The mirrored coils formed an extremely effective differential pickup structure which suppressed the system noise as high as 100 dB. The different combination of the inner and outer gradient current made the field free point (FFP) move in the Z direction with a uniform intensity of 0.54T/m, while the scanning in the XY direction was implemented mechanically. The third-harmonic signal of the Superparamagnetic Iron Oxide Nanoparticles (SPIONs) at the FFP was detected and then reconstructed synchronously with the current changes. Experiment results showed that the tomographic detection limit was 30 mm in the Z direction, and the sensitivity was about 10 μg Fe SPIONs at 40 mm distance with a spatial resolution of about 5 mm. In the rat experiment, 54 μg intramuscular injected SPIONs were detected successfully in the sentinel lymph node, in which the tracer content was about 1.2% total injected Fe. Additionally, the effective detection time window was confirmed from 4 to 6 min after injection. Relevant clinical ethics are already in the application process. Large mammalian SLNB MPI experiments and 3D preoperative SLNB imaging will be performed in the future.
Importance of ecosystem services and ecological security patterns on Hainan Island, China
Authors: Liu Haodong , Zhang Gaoqiang , Li Tianqi , Ren Siyuan , Chen Baihua , Feng Kaibin , Li Wei , Zhao Xiaoqing , Qin Pengyao , Zhao Junpeng 
Published: February 2024

The identification and restoration of damaged ecosystems are key to achieving ecological conservation and sustainable. Hainan Island is experiencing a serious crisis of biodiversity and habitat degradation. Therefore, its ecological conservation has become a priority and challenge for China. This study aimed to construct a multi-level ecological security pattern (ESP) based on the synergy of multiple ecosystem service functions and identify important ecological elements and ecological restoration areas. Based on the InVEST model, the circuit theory model, and a series of GIS spatial analysis methods, the importance of ecosystem functions (biodiversity maintenance, water conservation, carbon sequestration, and soil conservation) was evaluated, and ecological sources, ecological corridors, ecological pinch points, and ecological barrier points were identified. The results are as follows: 1) The best habitats in Hainan Island were distributed in the central mountainous area with diverse ecosystems, with an area of 10982.5 km2, accounting for 34.25% of the total suitable habitats. Low-level habitats are mainly distributed on tableland and coastal zones. Human disturbance is the direct cause of landscape patch fragmentation in low-level habitat areas. 2) A total of 65 large ecological sources with a total area of 8238.23 km2 were identified, which were concentrated in the biodiversity and water conservation areas in the central part of the island. 3) Crucial areas in Hainan Island mainly comprised forests and water bodies. Ecological corridors radiated across the entire area in the form of a spider web and connected all important ecological patches, including 138 ecological corridors (73 primary ecological corridors and 65 secondary ecological corridors), 222 ecological pinch points, and 198 ecological barrier points. In addition, the identified areas for restoration are primary areas in urgent need of protection and restoration. In general, the ecological pinch points are natural conservation areas supplemented by anthropogenic restoration, and the ecological barrier points demand equal attention for anthropogenic restoration and nature conservation. The ecosystem protection plan developed in this study will enrich the theoretical achievements of territorial spatial ecological planning in Hainan Island, and provides clear guidance for alleviating the contradiction between land use and economic development in Hainan Island.
Allograft function predicts mortality in kidney transplant recipients with severe COVID-19: a paradoxical risk factor
Authors: Luo Han , Wen Jingyu , Yang Hongji , Ran Qing , Hou Yifu 
Published: February 2024

IntroductionKidney transplant recipients (KTRs) are at a higher risk of severe coronavirus disease (COVID-19) because of their immunocompromised status. However, the effect of allograft function on the prognosis of severe COVID-19 in KTRs is unclear. In this study, we aimed to analyze the correlation between pre-infection allograft function and the prognosis of severe COVID-19 in KTRs.MethodsThis retrospective cohort study included 82 patients who underwent kidney transplantation at the Sichuan Provincial Peoples Hospital between October 1, 2014 and December 1, 2022 and were diagnosed with severe COVID-19. The patients were divided into decreased eGFR and normal eGFR groups based on the allograft function before COVID-19 diagnosis (n=32 [decreased eGFR group], mean age: 43.00 years; n=50 [normal eGFR group, mean age: 41.88 years). We performed logistic regression analysis to identify risk factors for death in patients with severe COVID-19. The nomogram was used to visualize the logistic regression model results.ResultsThe mortality rate of KTRs with pre-infection allograft function insufficiency in the decreased eGFR group was significantly higher than that of KTRs in the normal eGFR group (31.25% [10/32] vs. 8.00% [4/50], P=0.006). Pre-infection allograft function insufficiency (OR=6.96, 95% CI: 1.4633.18, P=0.015) and maintenance of a mycophenolic acid dose &gt;1500 mg/day before infection (OR=7.59, 95% CI: 1.0853.20, P=0.041) were independent risk factors, and the use of nirmatrelvir/ritonavir before severe COVID-19 (OR=0.15, 95% CI: 0.030.72, P=0.018) was a protective factor against death in severe COVID-19.ConclusionsPre-infection allograft function is a good predictor of death in patients with severe COVID-19. Allograft function was improved after treatment for severe COVID-19, which was not observed in patients with non-severe COVID-19.
Extensively drug-resistant Pseudomonas aeruginosa: clinical features and treatment with ceftazidime/avibactam and ceftolozane/tazobactam in a tertiary care university hospital center in Portugal – A cross-sectional and retrospective observational study
Authors: Mendes Pedro Diogo , Paulo Sérgio Eduardo , Santos Carla Mimoso , Fonseca Ana Bruschy , Melo Cristino José , Pereira Álvaro Ayres , Caneiras Cátia 
Published: February 2024

IntroductionExtensively drug-resistant Pseudomonas aeruginosa (XDR-PA) is a growing concern due to its increasing incidence, limited therapeutic options, limited data on the optimal treatment, and high mortality rates. The study aimed to characterize the population, the outcome and the microbiological characteristics of XDR-PA identified in a Portuguese university hospital center.MethodsAll XDR-PA isolates between January 2019 and December 2021 were identified. XDR-PA was defined as resistance to piperacillin-tazobactam, third and fourth generation cephalosporins, carbapenems, aminoglycosides and fluoroquinolones. A retrospective analysis of the medical records was performed.ResultsOne hundred seventy-eight individual episodes among 130 patients with XDR-PA detection were identified. The most common sources of infection were respiratory (32%) and urinary tracts (30%), although skin and soft tissue infections (18%) and primary bacteremia (14%) were also prevalent. Colonization was admitted in 64 cases. Several patients had risk factors for complicated infections, most notably immunosuppression, structural lung abnormalities, major surgery, hemodialysis or foreign intravascular or urinary devices. XDR-PA identification was more frequent in male patients with an average age of 64.3 ± 17.5 years. One non-susceptibility to colistin was reported. Only 12.4% were susceptible to aztreonam. Ceftazidime-avibactam (CZA) was susceptible in 71.5% of the tested isolates. Ceftolozane-tazobactam (C/T) was susceptible in 77.5% of the tested isolates. Antibiotic regimens with XDR-PA coverage were reserved for patients with declared infection, except to cystic fibrosis. The most frequently administered antibiotics were colistin (41 cases), CZA (39 cases), and C/T (16 cases). When combination therapy was used, CZA plus colistin was preferred. The global mortality rate among infected patients was 35.1%, significantly higher in those with hematologic malignancy (50.0%, p &lt; 0.05), followed by the ones with bacteremia (44.4%, p &lt; 0.05) and those medicated with colistin (39.0%, p &lt; 0.05), especially the ones with respiratory infections (60.0%). Among patients treated with CZA or C/T, the mortality rate seemed to be lower.DiscussionXDR-PA infections can be severe and difficult to treat, with a high mortality rate. Even though colistin seems to be a viable option, it is likely less safe and efficient than CZA and C/T. To the best of the authors’ knowledge, this is the first description of the clinical infection characteristics and treatment of XDR-PA in Portugal.
Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study
Authors: Otsuka Shotaro , Kikuchi Kiyoshi , Takeshita Yasufumi , Takada Seiya , Tani Akira , Sakakima Harutoshi , Maruyama Ikuro , Makizako Hyuma 
Published: February 2024

IntroductionCerebral white matter hyperintensities (WMHs) are commonly found in the aging brain and have been implicated in the initiation and severity of many central nervous system diseases. Furthermore, an increased WMH volume indicates reduced brain health in older adults. This study investigated the association between WMH volume and physical activity in older adults with depressive symptoms (DS) and mild memory impairment (MMI). Factors associated with the WMH volume were also investigated.MethodsA total of 57 individuals aged over 65 years with DS and MMI were included in this study. The participants underwent magnetic resonance imaging to quantify WMH volumes. After WMH volume was accumulated, normalized to the total intracranial volume (TIV), the percentage of WMH volume was calculated. In addition, all participants wore a triaxial accelerometer for 2 weeks, and the average daily physical activity and number of steps were measured. The levels of blood biomarkers including cortisol, interleukin-6 (IL-6), brain-derived insulin-like growth factor-1, and brain-derived neurotrophic factor were measured. Motor and cognitive functions were also assessed.ResultsFaster maximum walking speed and longer time spent engaged in moderate physical activity were associated with a smaller percent of WMH volume, whereas higher serum IL-6 levels were associated with a larger percent of WMH volume. The number of steps per day, time spent engaged in low levels of physical activity, cognitive function, and all other measured biomarkers were not significantly associated with percent of WMH volume.DiscussionHigher blood inflammatory cytokine levels, shorter duration of moderate physical activity, and lower maximum walking speed were associated with a higher percent of WMH volume. Our results provide useful information for maintaining brain health in older adults at a high risk of developing dementia and may contribute to the development of preventive medicine for brain health.
Kinesiophobia, limits of stability, and functional balance assessment in geriatric patients with chronic low back pain and osteoporosis: a comprehensive study
Authors: Alshahrani Mastour Saeed , Reddy Ravi Shankar 
Published: February 2024

BackgroundThe significance of studying Kinesiophobia, Limits of Stability (LOS), and functional balance in geriatric patients with CLBP and osteoporosis lies in their profound impact on rehabilitation outcomes and fall risk, ultimately affecting patients’ quality of life. This study aimed to examine LOS and functional balance in the geriatric population concurrently experiencing Chronic Low Back Pain (CLBP) and osteoporosis, in comparison to age-matched healthy controls; to assess the correlations between Kinesiophobia, LOS, and functional balance assessments; and to evaluate the mediating influence of Kinesiophobia on the association between LOS and functional balance tests.MethodsThis cross-sectional study included a total of 86 participants in each group. Kinesiophobia was assessed using the Tampa Scale of Kinesiophobia (TSK). LOS variables were evaluated with a computerized Iso-free platform in eight different directions. Functional balance was measured using the Timed Up and Go (TUG) test and the Berg Balance Scale (BBS).ResultsPatients with CLBP and osteoporosis showed significantly lower LOS percentages (45.78 ± 6.92) and impaired Functional Balance, reflected in a TUG Score (10.45 ± 2.23), compared to asymptomatic controls (LOS: 76.95 ± 8.21; TUG: 8.73 ± 1.90). Kinesiophobia showed a significant moderate negative correlation with LOS, indicated by r = −0.362 (p &lt; 0.01). Additionally, Kinesiophobia was found to correlate with functional balance tests. Specifically, there was a moderate positive correlation with the TUG Score (r = 0.322, p &lt; 0.01), indicating that higher Kinesiophobia is associated with slower TUG performance. Conversely, a stronger moderate negative correlation was observed with the Berg Balance Scale (BBS) Score (r = −0.436, p &lt; 0.001), suggesting that increased Kinesiophobia is associated with lower BBS scores, indicating poorer balance performance. Mediation analysis revealed that Kinesiophobia significantly influences LOS and Functional Balance. For LOS and the TUG score, Kinesiophobia showed a direct effect (B = 0.24), an indirect effect (B = 0.09), and a total effect (B = 0.13). Similarly, for LOS and the BBS score, the direct effect of Kinesiophobia was B = 0.38, with an indirect effect of B = 0.10 and a total effect of B = 0.20.ConclusionThis study underscores the substantial impact of Kinesiophobia on both stability and functional balance in individuals coping with CLBP and osteoporosis. The findings emphasize the clinical relevance of addressing Kinesiophobia as a potential target for interventions aimed at improving LOS and functional balance in this specific patient population.
Structure similarity virtual map generation network for optical and SAR image matching
Authors: Chen Shiwei , Mei Liye 
Published: February 2024

Introduction: Optical and SAR image matching is one of the fields within multi-sensor imaging and fusion. It is crucial for various applications such as disaster response, environmental monitoring, and urban planning, as it enables comprehensive and accurate analysis by combining the visual information of optical images with the penetrating capability of SAR images. However, the differences in imaging mechanisms between optical and SAR images result in significant nonlinear radiation distortion. Especially for SAR images, which are affected by speckle noises, resulting in low resolution and blurry edge structures, making optical and SAR image matching difficult and challenging. The key to successful matching lies in reducing modal differences and extracting similarity information from the images.Method: In light of this, we propose a structure similarity virtual map generation network (SVGNet) to address the task of optical and SAR image matching. The core innovation of this paper is that we take inspiration from the concept of image generation, to handle the predicament of image matching between different modalities. Firstly, we introduce the Attention U-Net as a generator to decouple and characterize optical images. And then, SAR images are consistently converted into optical images with similar textures and structures. At the same time, using the structural similarity (SSIM) to constrain structural spatial information to improve the quality of generated images. Secondly, a conditional generative adversarial network is employed to further guide the image generation process. By combining synthesized SAR images and their corresponding optical images in a dual channel, we can enhance prior information. This combined data is then fed into the discriminator to determine whether the images are true or false, guiding the generator to optimize feature learning. Finally, we employ least squares loss (LSGAN) to stabilize the training of the generative adversarial network.Results and Discussion: Experiments have demonstrated that the SVGNet proposed in this paper is capable of effectively reducing modal differences, and it increases the matching success rate. Compared to direct image matching, using image generation ideas results in a matching accuracy improvement of more than twice.
Child maltreatment among deaf and hard-of-hearing adolescent students: associations with depression and anxiety
Authors: Hammad Mohammad Ahmed , Al-Otaibi Mansour Nayef , Awed Huda Shaaban 
Published: February 2024

ObjectiveChild abuse and neglect have several short- and long-term consequences for the victim. Though Deaf and Hard-of-Hearing children are at higher risk of being maltreated as compared to hearing children, little research in Saudi Arabia has focused on this population. To determine the prevalence of child maltreatment and to examine its association with depression and anxiety among a sample of Deaf and Hard-of-Hearing students in Saudi Arabia, recruited from secondary schools in southern Saudi Arabia.MethodsThe sample included 186 Deaf and Hard-of-Hearing students aged 14–17 years (M = 15.7 years; SD = 3.41 years). Data were collected using the Child Abuse Self-Report Scale, Center for Epidemiological Studies Depression Scale for Children, and Generalized Anxiety Disorder Questionnaire. Bivariate and Linear regression analyses were conducted using SPSS 20.ResultsAbout 47.3% of the students were exposed severe to very severe child maltreatment. The severity of maltreatment varied based on parents’ educational and income level, number of children in the family, the Deaf and Hard-of-Hearing student’s gender, and parents’ hearing status. Linear regression analysis indicated that child maltreatment was a significant predictor of depression and anxiety in this sample.ConclusionConsidering the socio-demographic factors influencing the prevalence of maltreatment in the present study, it seems important to work with parents of Deaf and Hard-of-Hearing children to improve their skills in rearing a child with special needs. Addressing the social stigma and social barriers experienced by DHH individuals through familial, institutional, and community interventions may be a first step toward long-term prevention of maltreatment among DHH children.
Metabolic disturbances are risk factors for readmission to psychiatric hospitals in non-smokers but not in smokers: results from a Swiss psychiatric cohort and in first-episode psychosis patients
Authors: Laaboub Nermine , Locatelli Isabella , Grosu Claire , Piras Marianna , Ngoc Tram Ho , Ranjbar Setareh , Preisig Martin , Elowe Julien , von Gunten Armin , Conus Philippe , Eap Chin B. 
Published: February 2024

BackgroundPsychiatric patients are at high risk of readmission, and a high body mass index has previously been shown as a risk factor. We sought to replicate this finding and 1) to prospectively assess the association of metabolic syndrome and its five components with readmission in psychiatric hospitals and 2) to identify other clinical and sociodemographic predictors of readmission.MethodsBetween 2007 and 2019, data on 16727 admissions of 7786 adult and elderly patients admitted to the Department of Psychiatry of the Lausanne University Hospital, were collected. Metabolic syndrome was defined according to the International Diabetes Federation definition. Cox frailty models were used to investigate the associations between readmission and metabolic disturbances.ResultsA total of 2697 (35%) patients were readmitted to our psychiatric hospital. Novel risk factors for readmission in non-smokers were identified, including being overweight (HR=1.26; 95%CI=[1.05; 1.51]) or obese (HR=1.33; 95%CI=[1.08; 1.62]), displaying hypertriglyceridemia (HR=1.21; 95%CI=[1.04; 1.40]) and metabolic syndrome (HR=1.26; 95%CI=[1.02; 1.55]). Central obesity and hyperglycemia increased the risk of readmission when considering the Health of the Nation Outcome Scales variable. In first-episode psychosis patients, obesity (HR=2.23; 95%CI=[1.14; 4.30]) and high-density lipoprotein hypocholesterolemia (HR=1.90; 95%CI=[1.14; 3.20]) doubled the risk of readmission.ConclusionThe observed interaction between smoking and metabolic variables are compatible with a ceiling effect; metabolic variables increase the risk of readmission in non-smokers but not in smokers who are already at higher risk. Future studies should determine whether better metabolic monitoring and treatment can reduce readmission risk.
The association between the sense of control and depression during the COVID-19 pandemic: a systematic review and meta-analysis
Authors: Msetfi Rachel M. , Kornbrot Diana E. , Halbrook Yemaya J. 
Published: February 2024

IntroductionHigh levels of depression and low sense of control have been reported during the COVID-19 pandemic. The removal of typical freedoms through public health restrictions may have played an important role. The aim of this review was to examine data collected during the pandemic and (1) estimate the strength of the association between sense of control and depression, (2) examine whether the different types of control measures affected the strength of the association, and (3) whether this changed as a function of pandemic indicators.MethodsWe conducted a systematic review and meta-analysis of studies published in English between December 2019 and November 2022. A total of 993 articles were identified, of which 20 were included in the review and 16 in the meta-analysis after conducting a quality assessment using the standard NIH tool.ResultsThe control–depression association gave a bias-independent pooled effect size of r = .41, and grew stronger over the 130 weeks covered by this review but did not change as a function of local COVID incidence rates. Subgroup analyses showed that external and overall control were more strongly related to depression than internal control.DiscussionThese findings emphasize that external factors are important to the sense of control and the importance of preserving the sense of control in situations where the removal of personal freedoms is necessary, such as public health emergencies.