bluuebunny/crossref_metadata_2025_split huggingface dataset:
QUALITY OF LIFE AND MORTALITY IN PATIENTS WAITING FOR AN OPERATION FOR BONE AND JOINT INFECTION
Authors: Hotchen Andrew , Dudareva Maria , Frank Florian , Sukpanichy Sermsak , Corrigan Ruth , Ferguson Jamie , Stubbs David , McNally Martin 
Published: November 2023

AimTo investigate the impact of waiting for surgical treatment for bone and joint infection (BJI) on patient self-reported quality of life (QoL).MethodPatients presenting to clinic between January 2019 and February 2020 completed the EuroQol EQ-5D-5L questionnaire. Patients were divided into three groups: surgery performed; on the waiting list for surgery; or decision for non-operative management. All patients were followed-up for 2 years. The EQ-index score was calculated and change from presentation to 1-year and 2-year follow-up was compared across the 3 groups. Mortality at final follow-up was measured in all groups.Results188 patients were included. Of these, 98 had an operation performed, 50 were on the waiting list for surgery but did not receive an operation and 40 were treated non-operatively. At presentation, all three groups had similar EQ-5D-5L index scores (surgery:0.412 SD0.351; waiting list:0.510 SD0.320; non-operative management: 0.467 SD0.354; p=0.269). There was a significant improvement in QoL in patients who underwent surgery when compared to their pre-operative state (mean increase of EQ-index score +0.241 in the first year (SD0.333, p<0.001) and +0.259 (SD0.294, p<0.001) in the second year. Patients on the waiting list for surgery had a small time-dependent decrease in EQ-index score at 1 year (−0.077, SD0.282, p=0.188) and 2 years (−0.140, SD0.359, p=0.401). Patients treated non-operatively had similar changes in EQ-index scores at 1 year (−0.052, SD0.309, p=0.561) and 2 years (−0.146, SD 0.234, p=0.221). Patients who had surgery had significantly better QoL at 2-years after treatment compared to other groups (mean EQ-index scores: surgery performed 0.671 vs. waiting list 0.431, p<0.001; surgery performed vs. non-operative management 0.348, p<0.001).Mortality in the operated group was 3.1%, which was similar to patients who were on the waiting list for surgery (6.5%, p=0.394) but lower than patients who were non-operatively managed (14.7%, p=0.014).ConclusionsThe Covid-19 pandemic created long waiting times for some patients. Selecting patients with BJI who can safely wait for surgery is difficult. QoL for patients with BJI deteriorates over time if surgery is delayed or not performed. When patients decline surgery, they should be counselled that their QoL is likely to be impaired over time. The relationship between waiting time and mortality merits further study.
NOVEL DIAGNOSIS MARKER OF PERIPROSTHETIC JOINT INFECTION: A SYSTEMATIC REVIEW
Authors: Schindler Melanie , Walter Nike , Sigmund Irene Katharina , Maderbacher Günther , Alt Volker , Rupp Markus 
Published: November 2023

BackgroundThe identification of novel biomarker which is highly specific and sensitive for periprosthetic joint (PJI) have the potential to improve diagnostic accuracy and ultimately improve patient outcomes. Thus, the aim of this systemic review is to identify and evaluate novel biomarkers for the preoperative diagnostics of PJI.MethodsMEDLINE, EMBASE, PubMed and Cochrane Library databases identified from 1st of January 2018 to 30th of September. 2022. We used “periprosthetic joint infection” OR “prosthetic joint infection” OR “periprosthetic infection” as the diagnosis of interest and the target index applied AND “marker”. To focus on novel biomarkers already used biomarkers of the established PJI diagnostic criteria of MSIS, ICM and EBJIS were not included in the analysis. These three criteria were considered the reference standard during quality assessment.ResultsA total of 19 studies were included. In these, fourteen different novel biomarkers were analyzed. Fifteen studies (79%) had prospective designs and the other four (22%) were retrospective studies. Six studies (33%) included only periprosthetic knee infections and thirteen (67%) included periprosthetic knee and hip infections. Proteins were analyzed in most cases (nine studies), followed by molecules (three studies), exosome (two studies) as well as DNA (two studies), interleukin (one study) and lysosome (one study). One novel and promising marker that had been frequently analyzed is calprotectin.ConclusionNo marker demonstrated higher sensitivity and specificity than already known parameters used for standardized treatment based on established PJI definitions. Further studies are needed to elucidate the benefit and usefulness of implementing new biomarkers in diagnostic PJI settings.
GENOME-BASED ANALYSIS OF VIRULENCE FACTORS OF THE GENUS CUTIBACTERIUM ISOLATED FROM IMPLANT-ASSOCIATED INFECTIONS IN SLOVENIA
Authors: Erbeznik Anja , Šturm Andraž Celar , Smrdel Katja Strašek , Triglav Tina , Vodicar Polona Maver 
Published: November 2023

AimThe aim of our study was to analyze putative genes for virulence factors of Cutibacterium isolates obtained from implant-associated infections.MethodsWe analyzed 64 isolates of Cutibacterium spp. (C. acnes (53/64), C. avidum (6/64), C. granulosum (4/64), C. namnetense (1/64)) using NextSeq 550 (Illumina, San Diego, CA, USA) and performed genomic analysis of 24 genes associated with virulence factors (VFs) of C. acnes previously reported in the literature. Most isolates were obtained from implant-associated infections (IAI) between 2012–2021 at the Institute of Microbiology and Immunology, Faculty of Medicine, Ljubljana. Additionally, we included the first C. namnetense isolated in our laboratory from surgical site infection.ResultsC. acnes and C. namnetense have the highest number of VFs among those examined. The VFs gntK (shikimate kinase) and HYL-IB / II (hyaluronate lyase) are absent in phylotype IA1 (sequence types (ST) A, C, D according to the SLST scheme). Repressor gene of porphyrin synthesis, deoR is present in all Cutibacterium spp. isolates. The phylotypes II and IB show a similar distribution of VFs, with the presence of the VFs rcsB (compound for biofilm formation) and HYL-IA (hyaluronate lyase), which are absent in other C. acnes phylotypes and other Cutibacterium spp.In phylotypes IA1 and IB, the sequence of genes encoding VFs dsA1 and dsA2 does not have 100% genomic coverage, possibly indicating homologs between species. The isolates of C. acnes and C. namnetense possess all three CAMP (1,2,4) factors, which are not detected in other Cutibacterium spp. However, further analysis revealed species-specific CAMP factors in C. avidum and C. granulosum. Both species also have similar other genes for VFs, mainly encoding heat shock proteins and lipases, while VFs related to biofilm production are mostly absent (rcsB, ytpA).ConclusionWe found several differences in the distribution of VFs among Cutibacterium spp. isolated from IAI.
EXTENDED ANTIMICROBIAL PROPHYLAXIS DOES NOT IMPROVE OUTCOME OF UNEXPECTED PJI: A RANDOMIZED CONTROLLED TRIAL
Authors: Veerman Karin , Telgt Denise , Rijnen Wim , Goosen Jon 
Published: November 2023

AimIn 10% of the presumed aseptic hip or knee revisions, a low-grade infection is unexpectedly diagnosed based on the tissue samples taken during revision. Extended antimicrobial prophylaxis can possibly reduce the failure rate in cases of unexpected PJI, because the prophylaxis can be considered as early empiric treatment. In this randomized controlled study we analysed whether extended antimicrobial prophylaxis compared to a single dose is beneficial to improve the outcome of treatment in unexpected PJI in revision arthroplasty.MethodThis study was nested in a randomized clinical trial comparing single-dose cefazolin with prolonged prophylaxis (15 doses of cefazolin over 5 days) for revision arthroplasty of the hip or knee. For this analysis, patients were included if an unsuspected PJI (defined as ≥2 positive intraoperative tissue samples with the same microorganism) was diagnosed. PJI treatment consisted of 12 weeks of a rifampicin-based regimen in Staphylococcal PJI, without removal of the prosthesis. We examined Infection characteristics and success of treatment after one year, defined as the absence of signs or treatment for PJI during follow-up.ResultsAfter randomization of 662 patients, 68 unexpected PJI were diagnosed. In 5 cases no antimicrobial treatment was started. The success rate after one year follow-up for those who received PJI treatment was 96% (28/29) in the single dose group and 91% (31/34) in the extended prophylaxis group (p=1.00). The most frequently identified pathogens in unexpected PJI were Cutibacterium acnes (n=50) and Staphylococcus epidermidis (n=14). The causatives were susceptible for the cefazolin prophylaxis in 61 of the 63 cases. The interval between the stopped prophylaxis and the re-start of antimicrobial treatment was on average 10 days (SD 4) for the single dose and 5 days (SD 4) for the extended group. The mean duration of antimicrobial treatment was 83 days (SD 12) and did not differ between both groups (p=0.16).ConclusionsThis is the first randomized controlled trial in which extended prophylaxis showed no benefit on the prosthesis survival for patients with an unexpected PJI after assumed aseptic revision of the hip or knee prosthesis. The results imply that extended prophylaxis should not be given as part of early empiric therapy.
Estimates for bilinear θ-type generalized fractional integral and its commutator on new non-homogeneous generalized Morrey spaces
Authors: Lu Guanghui , Wang Miaomiao , Tao Shuangping 
Published: November 2023

Abstract
Let

(

X
,
d
,
μ

)

\left({\mathcal{X}},d,\mu )

be a non-homogeneous metric measure space satisfying the geometrically doubling and upper doubling conditions. In this setting, we first introduce a generalized Morrey space

M

p

u

(

μ

)

{M}_{p}^{u}\left(\mu )

, where

1
≤
p
<
∞

1\le p\lt \infty

and

u

(

x
,
r

)

:
X
×

(

0
,
∞

)

→

(

0
,
∞

)

u\left(x,r):{\mathcal{X}}\times \left(0,\infty )\to \left(0,\infty )

is a Lebesgue measurable function. Furthermore, under assumption that the measurable functions

u

1

,

u

2

{u}_{1},{u}_{2}

, and

u

u

belong to

W

τ

{{\mathbb{W}}}_{\tau }

with

τ
∈

(

0
,
2

)

\tau \in \left(0,2)

, we prove that the bilinear

θ

\theta

-type generalized fractional integral

T

˜

θ
,
α

{\widetilde{T}}_{\theta ,\alpha }

is bounded from the product of spaces

M

p

1

u

1

(

μ

)

×

M

p

2

u

2

(

μ

)

{M}_{{p}_{1}}^{{u}_{1}}\left(\mu )\times {M}_{{p}_{2}}^{{u}_{2}}\left(\mu )

into spaces

M

q

u

(

μ

)

{M}_{q}^{u}\left(\mu )

, where

u

1

u

2

=
u

{u}_{1}{u}_{2}=u

,

α
∈

(

0
,
1

)

\alpha \in \left(0,1)

, and

1

q

=

1

p

1

+

1

p

2

−
2
α

\frac{1}{q}=\frac{1}{{p}_{1}}+\frac{1}{{p}_{2}}-2\alpha

with

p

1

,

p

2

∈

(

1
,

1

α

)

{p}_{1},{p}_{2}\in \left(1,\frac{1}{\alpha })

, and also show that the

T

˜

θ
,
α

{\widetilde{T}}_{\theta ,\alpha }

is bounded from the product of spaces

M

p

1

u

1

(

μ

)

×

M

p

2

u

2

(

μ

)

{M}_{{p}_{1}}^{{u}_{1}}\left(\mu )\times {M}_{{p}_{2}}^{{u}_{2}}\left(\mu )

into spaces

M

1

u

(

μ

)

{M}_{1}^{u}\left(\mu )

, where

1
=

1

p

1

+

1

p

2

−
2
α

1=\frac{1}{{p}_{1}}+\frac{1}{{p}_{2}}-2\alpha

. Meanwhile, we prove that the commutator

T

˜

θ
,
α
,

b

1

,

b

2

{\widetilde{T}}_{\theta ,\alpha ,{b}_{1},{b}_{2}}

formed by

b

1

,

b

2

∈

RBMO

˜

(

μ

)

{b}_{1},{b}_{2}\in \widetilde{{\rm{RBMO}}}\left(\mu )

and

T

˜

θ
,
α

{\widetilde{T}}_{\theta ,\alpha }

is bounded from the product of spaces

M

p

1

u

1

(

μ

)

×

M

p

2

u

2

(

μ

)

{M}_{{p}_{1}}^{{u}_{1}}\left(\mu )\times {M}_{{p}_{2}}^{{u}_{2}}\left(\mu )

into spaces

M

q

u

(

μ

)

{M}_{q}^{u}\left(\mu )

, and it is also bounded from the product of spaces

M

p

1

u

1

(

μ

)

×

M

p

2

u

2

(

μ

)

{M}_{{p}_{1}}^{{u}_{1}}\left(\mu )\times {M}_{{p}_{2}}^{{u}_{2}}\left(\mu )

into spaces

M

1

u

(

μ

)

{M}_{1}^{u}\left(\mu )

.
Quo vadis, Onleihe? Ein Rück- und Ausblick aus Rheinland-Pfalz
Authors: Kalb Florian 
Published: November 2023

Zusammenfassung
Dass seit rund 15 Jahren in immer mehr Öffentlichen Bibliotheken auch eine Ausleihe digitaler Medien möglich ist, liegt maßgeblich am Start der Onleihe<fnote>Onleihe ist ein Portemanteau-Wort mit den Bestandteilen „online“ und „ausleihen“.</fnote> im Jahr 2007, die einen Paradigmenwechsel in den deutschen Öffentlichen Bibliotheken eingeläutet hat. Dieser Artikel gibt einen Überblick über die Entwicklung der Onleihe im Allgemeinen, beleuchtet dabei aber auch die speziellen Gegebenheiten in einem Flächenland wie Rheinland-Pfalz. Darüber hinaus kommen häufige Kritikpunkte wie die bekannte Lizenzproblematik im Bereich E-Lending sowie technische Probleme mit der Plattform, aber auch Lösungsansätze zu diesen Problematiken zur Sprache.
Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach
Authors: Dave Jaydeep , Ali Ali Muhammed Moula , Kudre Tanaji , Nukhthamna Pikunthong , Kumar Nishant , Kieliszek Marek , Bavisetty Sri Charan Bindu 
Published: November 2023

Abstract
This study aimed to efficiently utilize catfish heads, enhancing the oil extraction process while improving the cost-effectiveness of fish byproduct management. The study employed the wet rendering method, a solvent-free approach, utilizing a two-factor Taguchi orthogonal array design to identify critical parameters for optimizing oil yield and ensuring high-quality oil attributes. The extraction temperature (80–120°C) and time (5–25 min) were chosen as variables in the wet rendering process. Range analysis identified the extraction time as a more significant (p < 0.05) factor for most parameters, including oil yield, oil recovery, acid value, free fatty acids, peroxide value, and thiobarbituric acid reactive substances. The extraction temperature was more significant (p < 0.05) for oil color. Consequently, the wet rendering method was optimized, resulting in an extraction temperature of 80°C and an extraction time of 25 min, yielding the highest oil yield. This optimized wet rendering process recovered 6.37 g/100 g of oil with an impressive 54.16% oil recovery rate, demonstrating comparable performance to traditional solvent extraction methods. Moreover, Fourier transfer infrared spectra analysis revealed distinct peaks associated with triacylglycerols and polyunsaturated fatty acids (PUFA). The oil recovered under optimized conditions contained higher levels of PUFA, including oleic acid (189.92 μg/g of oil), linoleic acid (169.92 μg/g of oil), eicosapentaenoic acid (17.41 μg/g of oil), and docosahexaenoic acid (20.82 μg/g of oil). Volatile compound analysis revealed lower levels of secondary oxidation compounds under optimized conditions. This optimized wet rendering method offers practical advantages in terms of cost-efficiency, sustainability, reduced environmental impact, and enhanced oil quality, making it an attractive option for the fish processing industries. Future research possibilities may include the purification of the catfish head oil and its application in the food and pharmaceutical industries.
Cultural Studies, Big Data, Scalability: Benjamin Versus Bourdieu
Authors: Beebee Thomas Oliver 
Published: November 2023

Abstract
This essay argues that to be true to its name, Cultural Studies relies on a Big Data tapestry of culture against which individual events may be foregrounded. In the majority of cases, this cultural background is the implied first premise of a syllogism and the scholarly argument becomes an enthymeme. Sometimes, however, the presentation of Big Data becomes the argument in and of itself. After explaining the concept of Cultural Studies with which I am working, as well as the definition and difficulties posed by Big Data, I analyze and compare two precursor works that plainly gather and analyze Big Data to explain cultural moments: Walter Benjamin’s Passagen-Werk (Arcades Project); and Pierre Bourdieu’s La distinction (Distinction). Both works raise the question of how their examples can be scaled to the totalizing visions of culture that they seek, and the two researchers take wildly different approaches to the question of scalability that always lurks behind Big Data approaches.
Performance evaluation of a novel high-sensitivity cardiac troponin T assay: analytical and clinical perspectives
Authors: Li Zhongxin , Yang Shuo , Qiao Jiao , Tan Yuan , Liu Qi , Yang Boxin , Feng Weimin , Cui Liyan 
Published: November 2023

Abstract

Objectives
To evaluate the analytical characteristics of a novel high-sensitivity cardiac troponin T (hs-cTnT) test on the automatic light-initiated chemiluminescent assay (LiCA®) system, and validated its diagnostic performance for non-ST-segment elevation myocardial infarction (NSTEMI).

Methods
Studies included an extensive analytical evaluation and established the 99th percentile upper reference limit (URL) from apparently healthy individuals, followed by a diagnostic performance validation for NSTEMI.

Results
Sex-specific 99th percentile URLs were 16.0 ng/L (1.7 % CV: coefficient of variation) for men (21–92 years) and 13.4 ng/L (2.0 % CV) for women (23–87 years) in serum, and 30.6 ng/L (0.9 % CV) for men (18–87 years) and 20.2 ng/L (1.4 % CV) for women (18–88 years) in heparin plasma. Detection rates in healthy individuals ranged from 98.9 to 100 %. An excellent agreement was identified between LiCA® and Elecsys® assays with a correlation coefficient of 0.993 and mean bias of −0.7 % (−1.8–0.4 %) across the full measuring range, while the correlation coefficient and overall bias were 0.967 and −1.1 % (−2.5–0.3 %) for the lower levels of cTnT (10–100 ng/L), respectively. At the specific medical decision levels (14.0 and 52.0 ng/L), assay difference was estimated to be <5.0 %. No significant difference was found between these two assays in terms of area under curve (AUC), sensitivity and specificity, negative predictive value (NPV) and positive predictive value (PPV) for the diagnosis of NSTEMI.

Conclusions
LiCA® hs-cTnT is a reliable 3rd-generation (level 4) high-sensitivity assay for detecting cardiac troponin T. The assay is acceptable for practical use in the diagnosis of NSTEMI.
A model for managing quality control for a network of clinical chemistry instruments measuring the same analyte
Authors: Giannoli Jean-Marc , Bernard Mathieu , L’Hirondel Julien , Heim André , Badrick Tony 
Published: November 2023

Abstract

Objectives
Monitoring quality control for a laboratory or network with multiple instruments measuring the same analyte is challenging. We present a retrospective assessment of a method to detect medically significant out-of-control error conditions across a group of instruments measuring the same analyte. The purpose of the model was to ensure that results from any of several instruments measuring the same analytes in a laboratory or a network of laboratories provide comparable results and reduce patient risk. Limited literature has described how to manage QC in these very common situations.

Methods
Single Levey–Jennings control charts were designed using peer group target mean and control limits for five common clinical chemistry analytes in a network of eight analyzers in two different geographical sites. The QC rules used were 13s/22s/R4s, with the mean being a peer group mean derived from a large population of the same instrument and the same QC batch mean and a group CV. The peer group data used to set the target means and limits were from a quality assurance program supplied by the instrument supplier. Both statistical and clinical assessments of significance were used to evaluate QC failure. Instrument bias was continually monitored.

Results
It was demonstrated that the biases of each instrument were not statistically or clinically different compared to the peer group’s average over six months from February 2023 until July 2023. Over this period, the error rate determined by the QC model was consistent with statistical expectations for the 13s/22s/R4s rule. There were no external quality assurance failures, and no detected error exceeded the TEa (medical impact). Thus, the combined statistical/clinical assessment reduced unnecessary recalibrations and the need to amend results.

Conclusions
This paper describes the successful implementation of a quality control model for monitoring a network of instruments, measuring the same analytes and using externally provided quality control targets. The model continually assesses individual instrument bias and imprecision while ensuring all instruments in the network meet clinical goals for quality. The focus of this approach is on detecting medically significant out-of-control error conditions.
Estimation of the reference values and decision limits for growth hormone in newborns using dried blood spots
Authors: Vidali Matteo , Giacchetti Federico , Sangiorgio Andrea , Vantaggiato Chiara , Rodari Giulia , Orsenigo Chiara , Di Modugno Adriana , Napolitano Filomena , Morniroli Daniela , Colombo Lorenzo , Profka Eriselda , Vizzari Giulia , Mosca Fabio , Ceriotti Ferruccio , Mantovani Giovanna , Arosio Maura , Giannì Maria L. , Giavoli Claudia 
Published: November 2023

Abstract

Objectives
Severe deficiency of growth hormone (GHD) of the newborn is a rare but potentially life-threatening disease. GH measured during the first week of life, using dried blood spots (DBS), may offer several advantages. Aim of the study was to estimate the reference values for GH in newborns by a new analytical method using DBS.

Methods
Using a new developed analytical method, GH was estimated from DBS of 1,036 healthy newborns attending the Neonatology Unit of Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan in the period July–October 2021. Reference values for GH deficiency were estimated by the Harrell–Davis bootstrap method, with 90 %CI calculated by the bias-corrected and accelerated bootstrap method.

Results
All GH measurements required 33 analytical sessions (8 months) with a CV% for calibration curve slopes equal to 6.9 %. Intermediate precision evaluated by measurement of low (3 μg/L) and high (10 μg/L) quality controls was, respectively, 14 and 6.5 %. GH reference values, estimated at percentiles 1.0st, 2.5th and 5.0th, and their 90 %CI, were, respectively, 4.5 μg/L (90 %CI 3.8–5.1), 5.9 μg/L (90 %CI 5.4–6.4) and 7.0 μg/L (90 %CI 6.7–7.3). GH levels were not associated with sex, standard deviation scores, birth weight, gestational age, type of delivery or mother’s variables (age, smoking habit, gestational diabetes).

Conclusions
Validation data suggest that this method can be used to measured GH in newborns using DBS. The reference values estimated in this study are in accordance with previous published works using ELISA and may help confirming the clinical suspicion of neonatal GHD.
The valuation pairing on an upper cluster algebra
Authors: Cao Peigen , Keller Bernhard , Qin Fan 
Published: November 2023

AbstractIt is known that many (upper) cluster algebras are not unique factorization domains. We exhibit the local factorization properties with respect to any given seedt: any non-zero element in a full rank upper cluster algebra can be uniquely written as the product of a cluster monomial intand another element not divisible by the cluster variables int. Our approach is based on introducing the valuation pairing on an upper cluster algebra: it counts the maximal multiplicity of a cluster variable among the factorizations of any given element. We apply the valuation pairing to obtain many results concerning factoriality,d-vectors,F-polynomials and the combinatorics of cluster Poisson variables. In particular, we obtain that full rank and primitive upper cluster algebras are factorial; an explanation ofd-vectors using valuation pairing; a cluster monomial in non-initial cluster variables is determined by itsF-polynomial; theF-polynomials of non-initial cluster variables are irreducible; and the cluster Poisson variables parametrize the exchange pairs of the corresponding upper cluster algebra.