bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell signaling through membrane mucins
Authors: Carraway Kermit L. , Ramsauer Victoria P. , Haq Bushra , Carothers Carraway Coralie A. 
Published: January 2003

AbstractMUC1 and MUC4 are the two membrane mucins that have been best characterized. Although they have superficially similar structures and have both been shown to provide steric protection of epithelial surfaces, recent studies have also implicated them in cellular signaling. They act by substantially different mechanisms, MUC4 as a receptor ligand and MUC1 as a docking protein for signaling molecules. MUC4 is a novel intramembrane ligand for the receptor tyrosine kinase ErbB2/HER2/Neu, triggering a specific phosphorylation of the ErbB2 in the absence of other ErbB ligands and potentiating phosphorylation and signaling through the ErbB2/ErbB3 heterodimeric receptor complex formed in the presence of neuregulin. In contrast, MUC1 has a highly conserved cytoplasmic tail, which binds β‐catenin, a key component of adherens junctions and a regulator of transcription, in a process that is tightly regulated by MUC1 phosphorylation. The specific localization of these membrane mucins to the apical surfaces of epithelial cells suggests that their signaling functions may be important as sensor mechanisms in response to invasion or damage of epithelia. BioEssays 25:66–71, 2003. © 2002 Wiley Periodicals, Inc.
The viral control of cellular acetylation signaling
Authors: Caron Cécile , Col Edwige , Khochbin Saadi 
Published: January 2003

AbstractIt is becoming clear that the post‐translational modification of histone and non‐histone proteins by acetylation is part of an important cellular signaling process controling a wide variety of functions in both the nucleus and the cytoplasm. Recent investigations designate this signaling pathway as one of the primary targets of viral proteins after infection. Indeed, specific viral proteins have acquired the capacity to interact with cellular acetyltransferases (HATs) and deacetylases (HDACs) and consequently to disrupt normal acetylation signaling pathways, thereby affecting viral and cellular gene expression. Here we review the targeting of cellular HATs and HDACs by viral proteins and highlight different strategies adopted by viruses to control cellular acetylation signaling and to accomplish their life cycle. BioEssays 25:58–65, 2003. © 2002 Wiley Periodicals, Inc.
Activation of the JNK signaling pathway: Breaking the brake on apoptosis
Authors: Lin Anning 
Published: January 2003

AbstractThe JNK signaling pathway is involved in regulation of many cellular events, including growth control, transformation and programmed cell death (apoptosis). The role of JNK activation in apoptosis is highly controversial, being suggested to have a pro‐apoptotic, anti‐apoptotic or no role in this process. It appears that the JNK pathway functions in a cell‐type and stimulus‐dependent manner and its different components can sometimes play opposing roles in apoptosis. Recent studies reveal that the effect of JNK activation on apoptosis depends on the activity of other signaling pathways like the NF‐κB pathway. Here we propose a model that can explain how activation of the JNK pathway “breaks the brake” on apoptosis, thereby regulating, but not initiating the apoptotic process. BioEssays 25:17–24, 2003. © 2002 Wiley Periodicals, Inc.
Localizing synaptic mRNAs at the neuromuscular junction: It takes more than transcription
Authors: Chakkalakal Joe V. , Jasmin Bernard J. 
Published: January 2003

AbstractThe neuromuscular junction has been used for several decades as an excellent model system to examine the cellular and molecular events involved in the formation and maintenance of a differentiated chemical synapse. In this context, several laboratories have focused their efforts over the last 15 years on the important contribution of transcriptional mechanisms to the regulation of the development and plasticity of the postsynaptic apparatus in muscle fibers. Converging lines of evidence now indicate that post‐transcriptional events, operating at the level of mRNA stability and targeting, are likely to also play key roles at the neuromuscular junction. Here, we present the recent findings highlighting the role of these additional molecular events and extend our review to include data showing that post‐transcriptional events are also important in the control of the expression of genes encoding synaptic proteins in muscle cells placed under different conditions. Finally, we discuss the possibility that mis‐regulation of post‐transcriptional events can occur in certain neuromuscular diseases and cause abnormalities of the neuromuscular junction. BioEssays 25:25–31, 2003. © 2002 Wiley Periodicals, Inc.
Size isn't everything
Authors: Tyler David , Baker Nicholas E. 
Published: January 2003

AbstractMuch progress has been made recently towards uncovering the mechanisms that control the size to which organisms and their organs grow, and identifying some of the genes responsible. Size control, however, is only half of the equation. In growing to the right size, tissues must also grow to the right shape. A recent paper1 suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved. BioEssays 25:5–8, 2003. © 2002 Wiley Periodicals, Inc.
Leeds inquiry into infant deaths: the importance of abuse and neglect in sudden infant death
Authors: Hobbs Christopher J. , Wynne Jane M. , Gelletlie R. 
Published: January 2003

AbstractResults of detailed inquiry into 37 unexpected deaths in infancy in Leeds over 18 months in 1991/2 revealed issues of abuse or neglect in 27, in 10 of which it was the major concern. Important findings included non‐organic failure to thrive, injury, or history suggesting suffocation. A history of abuse and neglect in parents as children, prior involvement with social services, poverty and social deprivation, the family struggling to cope and abuse or neglect of siblings were also identified. Deaths from child abuse and neglect are frequently not recognized in official reporting systems and it is likely that there are deaths registered as SIDS which are the result of maltreatment. Recognition depends on creating a jigsaw picture of all the circumstances surrounding the infant and family. Failure to recognize a death from maltreatment may leave other children at risk. Copyright © 1995 John Wiley & Sons, Ltd.
A continuum of child‐rearing: responding to traditional practices
Authors: Koramoa John , Lynch Margaret A. , Kinnair Donna 
Published: January 2003

AbstractProfessionals working in a multicultural society must be sensitive to diverse cultural approaches to child‐rearing and be able to distinguish between those traditions that can cause harm and ones which positively enhance the child's cultural identity. This can be helped by viewing childcare practices on a continuum ranging from those that are unequivocally harmful, e.g. female circumcision, and therefore legitimate targets for abolition to those which, because of their benefits, deserve to be actively preserved and promoted. Most traditional practices encountered in the UK are between these two extremes, but can be positively or negatively influenced by local knowledge and attitudes. A West African culture is used to provide specific examples and to illustrate a framework based on the continuum. Copyright © 2002 John Wiley & Sons, Ltd.
Does professional and public opinion in child abuse differ? An issue of cross‐cultural policy implementation
Authors: Chan Jasmine S. , Elliott John M. , Chow Yvonne , Thomas Joyce I. 
Published: January 2003

AbstractThere are cultural variations in childcare and socialisation practices, and actions considered abuse in one culture may be acceptable in others. The extent to which children's rights are regarded as such within their own cultures as well as by governments may vary greatly. Moreover, there is a tendency for the public to make allowances for the intentions and circumstances of child abusers, at least in less severe or obvious cases or where the actions in question are socially sanctioned. However, there are also many professions involved in prevention or remediation of child abuse, or in the implementation of policies on children generally. Medicine, law, education and the social services are especially relevant here. Professionals in these areas could be expected by virtue of their training and experience to bring to their grasp of abuse issues a dimension that transcends cultural variation. Evidence from the literature and from two Singapore studies is used to explore the possibility that many professionals may retain attitudes to child maltreatment that reflect their culture rather than any transcultural agreement on children's rights generally or child abuse specifically. If true, changing professional attitudes should be an important priority. Copyright © 2002 John Wiley & Sons, Ltd.
Culturally competent protection of children's mental health
Authors: Walker Steven 
Published: January 2003

AbstractThe protection of the mental health of black and other ethnic minority children and young people has not received adequate attention in the literature. This paper considers, describes and discusses the concept of culturally competent practice. Ways in which practitioners can better understand the needs of children in a multicultural, diverse society and intervene in more effective ways are assessed. Finally, the components of a culturally competent practice to support families in the protection of children's mental health are summarized, together with the implications for practice. Copyright © 2002 John Wiley & Sons, Ltd.
A new dedicated stent and delivery system for the treatment of bifurcation lesions: Preliminary experience
Authors: Toutouzas Konstantinos , Stankovic Goran , Takagi Takuro , Albiero Remo , Corvaja Nicola , Milici Caterina , Di Mario Carlo , Finci Leo , Colombo Antonio 
Published: January 2003

AbstractWe report the first clinical experience in eight patients with a new stent and delivery system specifically designed for the treatment of bifurcational lesions. The device (AST SLK‐View system) consists of a premounted stent and a delivery system. The stent has a side aperture, which orients toward the ostium of the side branch. The system allows deployment of the stent while the access to both main and side branches is maintained by two wires. We evaluated this system in nine bifurcations. The location of bifurcations was left descending artery/diagonal branch in four lesions, left circumflex/obtuse marginal branch in three lesions, and postero‐lateral branch/posterior descending artery in two lesions. Predilation was performed in six lesions of the main branches and in five lesions of the side branches. The stent was effectively delivered to all bifurcations except for one, in which the target lesion was located at a distal segment and the device could not be delivered. Following stent implantation in the main branch, two lesions at the side branches were treated by stent, while the other lesions were treated by balloon angioplasty without difficulty. Final kissing balloon was performed in four bifurcation lesions. No adverse event was observed during 1 month of clinical follow‐up. Treatment of bifurcation lesions with this new dedicated device appears to be feasible. This new device may introduce a new approach for the treatment of coronary bifurcation lesions. Cathet Cardiovasc Intervent 2003;58:34–42. © 2003 Wiley‐Liss, Inc.
Subacute stent thrombosis associated with a heparin‐coated stent and heparin‐induced thrombocytopenia
Authors: Cruz Daniel , Karlsberg Ronald , Takano Yuzuru , Vora Devandra , Tobis Jonathan 
Published: January 2003

AbstractSubacute stent thrombosis occurred in a patient 34 days after receiving a heparin‐coated (HC) stent. The patient developed heparin‐induced thrombocytopenia and diffuse thrombosis after the stent was placed. This raises the concern that patients who develop heparin‐associated antibodies in the context of a recently placed HC stent may have an increased risk for subacute stent thrombosis. Cathet Cardiovasc Intervent 2003;58:80–83. © 2003 Wiley‐Liss, Inc.
Cardiac perforation following transcatheter PFO closure
Authors: Trepels Thomas , Zeplin Harald , Sievert Horst , Billinger Kai , Krumsdorf Ulrike , Zadan Elisabeth , Horvath Kathrin 
Published: January 2003

AbstractFrom December 1998 to August 2001, transcatheter closure of patent foramen ovale (PFO) with an Amplatzer PFO occluder has been successfully performed in our center in 102 patients without severe complications. We are reporting the first known case of cardiac perforation by an Amplatzer PFO occluder. Cathet Cardiovasc Intervent 2003;58:111–113. © 2003 Wiley‐Liss, Inc.
Continuous veno‐venous hemofiltration for the treatment of contrast‐induced acute renal failure after percutaneous coronary interventions
Authors: Marenzi GianCarlo , Bartorelli Antonio L. , Lauri Gianfranco , Assanelli Emilio , Grazi Marco , Campodonico Jeness , Marana Ivana 
Published: January 2003

AbstractAcute renal failure (ARF) requiring hemodialysis after percutaneous coronary interventions (PCI) is a serious complication with poor prognosis. Hemodialysis‐induced hypotension may have deleterious cardiovascular effects, especially in high‐risk patients. Ultrafiltrate removal and simultaneous fluid replacement with a solution similar to plasma for high‐volume controlled hydration can be obtained with hemodynamic stability by continuous veno‐venous hemofiltration (CVVH). We prospectively assessed the safety and effectiveness of percutaneous CVVH (Y‐shaped double‐lumen catheter, circuit originating from and terminating in the femoral vein) in 33 consecutive patients (23 men and 10 women; mean age, 69 ± 9 years) who, after PCI, developed oligo‐anuric ARF, associated in 20 of them with congestive heart failure. All patients received a concomitant infusion of furosemide (500–1,000 mg/day) and dopamine (2 μg/kg/min). During CVVH, the average fluid volume replacement and body fluid net reduction were 1,000 ± 247 and 75 ± 48 ml/hr, respectively. Treatment with CVVH continued for 4.7 ± 2.7 days and corrected fluid overload in all cases. No patient experienced systemic hypotension or hypovolemia. Diuresis recovered in 32 (97%) patients, who showed a parallel improvement of renal function parameters. One patient required chronic dialysis. In‐hospital and 1‐year mortality was 9.1% and 27.3%, respectively. In conclusion, our data indicate that CVVH is a safe and effective therapy of radiocontrast‐induced ARF following PCI. It temporarily replaces renal function without deleterious cardiovascular effects, allowing the kidney to recover from the nephrotoxic injury. However, despite promising early results, large randomized trials are required to define the role of CVVH in ARF after PCI. Cathet Cardiovasc Intervent 2003;58:59–64. © 2003 Wiley‐Liss, Inc.
Coronary angiography in the fully anticoagulated patient: The transradial route is successful and safe
Authors: Hildick‐Smith David J.R. , Walsh John T. , Lowe Martin D. , Petch Michael C. 
Published: January 2003

AbstractThe radial approach to coronary angiography is intuitively attractive for fully anticoagulated patients (INR > 2) but no data exist concerning efficacy or safety of this procedure. The consensus view is that the femoral approach is contraindicated in fully anticoagulated patients, and though some operators undertake femoral catheterization in such patients and use closure devices, there are no data to suggest that it is safe to do so. At our institution, the radial approach for coronary angiography is reserved for patients in whom there is a relative contraindication to the femoral route. We have undertaken over 600 radial coronary angiograms in such patients since 1996, 66 of whom underwent transradial catheterization specifically because of anticoagulation status (INR > 2). Thirty‐eight patients (58%) were male, average age 67 ± 11 years. All 66 patients had an INR > 2 but < 4.5. The approach was left radial in 26 (39%), right radial in the remainder; sheath size was 4 Fr in 4 (6%), 5 Fr in 13 (20%), and 6 Fr in 49 (74%). Seven operators in total were involved, though two operators undertook the majority of cases (47; 71%). Success rate was 97%, with no failure of access, and only one minor postprocedural hemorrhage. Failures were due to radial artery atherosclerosis (1) and subclavian tortuosity (1). The radial approach to coronary angiography is safe and to be recommended in the fully anticoagulated patient. Cathet Cardiovasc Intervent 2003;58:8–10. © 2003 Wiley‐Liss, Inc.
Direct coronary stenting without balloon predilation of lesions requiring long stents: Immediate and 6‐month results of a multicenter prospective registry
Authors: Boulmier Dominique , Bedossa Marc , Commeau Philippe , Huret Bruno , Gilard Martine , Boschat Jacques , Brunel Philippe , Leurent Bernard , Le Breton Hervé 
Published: January 2003

AbstractTo assess the outcomes of direct coronary stenting (DS) using long stents and examine predictive factors of DS failure, this prospective multicenter registry included 128 consecutive patients who underwent the implantation of stents ≥ 18 mm in length without balloon predilation for de novo coronary artery stenoses. Mean lesion and stent lengths were 20.7 ± 5.4 and 21.4 ± 3.8 mm, respectively. Rates of DS success, lesion success, and primary success were 82%, 99%, and 97.7%, respectively. At 6 months, rates of MACE and TVR were 12.5% and 6.3%, respectively. In multivariate analysis, factors predictive of DS failure vs. DS success were presence of calcifications (78% vs. 45%; P = 0.004) and reference vessel diameter (2.77 ± 0.4 vs. 3.13 ± 0.42 mm; P = 0.0002). DS of complex lesions with stents ≥ 18 mm in length was performed safely and with a high success rate. This strategy was less successful in the treatment of small vessels and in presence of calcifications. Cathet Cardiovasc Intervent 2003;58:51–58. © 2003 Wiley‐Liss, Inc.
Right coronary arteriography: Experience with standard‐torque and limited‐torque techniques in children and young adults
Authors: Day Ronald W. 
Published: January 2003

AbstractCoronary spasm and intimal injury may occur during selective right coronary arteriography. The safety and efficacy of right coronary arteriography in children and young adults were retrospectively reviewed for this report. Right coronary arteriography was performed in 200 patients. A standard‐torque technique was used in 150 patients, a limited‐torque technique was used with a reshaped left coronary catheter in 53 patients. The standard‐torque technique was associated with proximal coronary spasm in nine patients, nonsustained ventricular tachycardia in one patient, and ST segment changes in one patient. The limited‐torque technique was associated with no complications. The standard‐torque technique was effective in one patient when the limited‐torque technique failed to define distal coronary branches clearly. The limited‐torque technique was effective in nine patients when the right coronary artery could not be engaged while attempting the standard‐torque technique. In conclusion, right coronary arteriography may be performed in a safe and potentially more effective manner using a new catheter design and a limited‐torque technique. Cathet Cardiovasc Intervent 2003;58:119–123. © 2003 Wiley‐Liss, Inc.
Longitudinal stent fracture 11 months after implantation in the left pulmonary artery and successful management by a stent‐in‐stent maneuver
Authors: Knirsch Walter , Haas Nikolaus A. , Lewin Martin A.G. , Uhlemann Frank 
Published: January 2003

AbstractFracture of a 12 mm Palmaz stent after implantation in the left pulmonary artery for palliation of postoperative stenosis in a 9‐year‐old child is described. Successful management by implantation of a second Palmaz stent revealed immediate stabilization and no signs of significant restenosis during 1‐year follow‐up. Cathet Cardiovasc Intervent 2003;58:116–118. © 2003 Wiley‐Liss, Inc.
Transcatheter Amplatzer duct occluder closure of direct right pulmonary to left atrium communication
Authors: Zanchetta Mario , Rigatelli Gianluca , Pedon Luigi , Zennaro Marco , Maiolino Pietro , Onorato Eustaquio 
Published: January 2003

AbstractAlthough rare, a congenital direct communication between pulmonary artery and left atrium can present a paradoxical embolism in adults. In our case, diagnosis was first made on contrast transcranial Doppler with Valsalva maneuver and subsequently confirmed by intracardiac echocardiography and selective pulmonary angiography. Successful catheter‐based closure using Amplatzer duct occluder device resulted in definitive exclusion of the source of paradoxical embolism. Cathet Cardiovasc Intervent 2003;58:107–110. © 2003 Wiley‐Liss, Inc.
Outcome of access site in patients treated with platelet glycoprotein IIb/IIIa inhibitors in the era of closure devices
Authors: Assali Abid R. , Sdringola Stefano , Moustapha Ali , Ghani Mohammad , Salloum Joseph , Schroth George , Fujise Ken , Anderson H. Vernon , Smalling Richard W. , Rosales Oscar R. 
Published: January 2003

AbstractThe most consistent procedural predictor of vascular access site complications thus far has been the intensity and duration of anticoagulant therapy during and after percutaneous coronary interventions (PCI). Several devices have been developed to aid in the closure of the femoral arteriotomy. This report describes the clinical outcome of unsuccessful deployment of femoral closure devices in a cohort of 285 consecutive patients who underwent PCI and were treated with platelet glycoprotein (GP) IIb/IIIa inhibitors. Manual femoral artery compression was used in 123 patients, Perclose in 123 patients, and AngioSeal in 39 patients. Successful homeostasis was achieved in 98.4% of patients who received manual compression, in 91.9% of the Perclose‐sealed arteriotomy, and in 84.6% of patients who received the AngioSeal closure device (P = 0.004). The incidence of vascular complications after successful deployment was 9%. Patients not achieving hemostasis with closure device or 1° manual compression developed complications in the majority of cases (> 80%; P < 0.05). By multivariate analysis (with adjustment for baseline differences), the use of AngioSeal closure device was found to be an independent risk factors leading to primary deployment failure and all access site complications (OR 2.97; 95% CI 1.5–6.0; P = 0.006). In summary, failed hemostasis by artery closure devices in patients undergoing PCI who are treated with GP IIb/IIIa inhibitors is associated with significant vascular complications. AngioSeal may be associated with a higher failure rate, while manual compression and Perclose seem to be more effective with a lower complication rate. Cathet Cardiovasc Intervent 2003;58:1–5. © 2003 Wiley‐Liss, Inc.