bluuebunny/crossref_metadata_2025_split huggingface dataset:
When support seekers encounter unsettling responses: A dual-factor approach
Authors: Cheng Shih-Ying , Taylor Elizabeth , Hamby Sherry 
Published: October 2023

Summary Accumulating evidence indicates the multifaceted nature of social support. Although support seekers may receive help, they may also encounter upsetting responses. It remains unclear how seeking and receiving social support, when differentiated, are associated with individuals’ strengths and well-being. This study collected survey data from 357 adults recruited from the southeastern United States. We classified participants using the factors of support seeking and support received into four groups: Interconnected (high on support seeking and receiving), Tended (low on support seeking, high on support receiving), Rebuffed (high on support seeking, low on support receiving), and Isolated (low on support seeking and receiving). We then examined the differences among groups. Findings The study found significant differences among the four groups in measures of regulatory strengths, meaning-making strengths, interpersonal strengths, and perceived well-being. In general, the Interconnected group scored highest among the four groups, followed by the Tended group, the Rebuffed group, and lastly, the Isolated group. Applications The finding that the Rebuffed group did not score significantly lower than the Isolated group underscores the importance of support seeking. Individuals may benefit from the support seeking process even though they do not obtain the support needed. Social work practitioners should facilitate and optimize their clients’ support seeking, including removing clients’ barriers to support seeking and addressing clients’ negative experiences in the support seeking process. Social work researchers should measure multiple aspects of social support, including support received and support seeking.
Intracranial stenting versus aggressive medical therapy for symptomatic intracranial stenosis: A meta-analysis of multicenter randomized controlled trials and an expert assessment of the current data
Authors: Doheim Mohamed F , Al-Bayati Alhamza R , Bhatt Nirav R , Lang Michael , Starr Matthew , Rocha Marcelo , Gross Bradley A. , Nogueira Raul G 
Published: October 2023

Background Intracranial atherosclerotic stenosis (ICAS) is associated with high risk of recurrent strokes despite best medical management (MM). We aimed to synthesize the evidence from randomized studies comparing intracranial stenting plus MM versus MM alone. Methods Comprehensive search of MEDLINE database was performed until May 2023. The data were extracted and pooled as risk ratio (RR) with 95% confidence interval (95% CI). Results We included three multicenter RCTs totaling 919 patients. As compared to MM alone, intracranial stenting was associated with statistically significant higher risks of any stroke or death (RR = 2.93, 95%CI [1.80–4.78], p < 0.0001), stroke in the same territory of qualifying artery (RR = 3.56, 95%CI [1.97–6.44], p < 0.0001), any ischemic stroke (RR = 2.22, 95%CI [1.27–3.87], p = 0.005), hemorrhagic stroke (RR = 13.49, 95%CI [2.59–70.15], p = 0.0002), and death (RR = 5.43, 95%CI [1.21–24.40], p = 0.003) within 30 days of randomization. There was a persistent lack of benefit and signals of harm at the last follow up within 1–3 years: any stroke or death (RR = 1.57, 95%CI [0.92–2.67], p =  0.1), stroke in the same territory of qualifying artery (RR = 1.84, 95%CI [0.97–3.50], p =  0.06), any ischemic stroke (RR = 1.56, 95%CI [1.11–2.20], p =  0.01), death (RR = 1.61, 95%CI [0.77–3.38], p =  0.2). The cumulative rate of stroke in the same territory of qualified artery with MM alone within the 1–3-year follow up was lower than expected, with only 47 out of the 450 (10.4%) MM alone patients suffering such events. Conclusion The findings from this meta-analysis do not recommend stenting as a routine care option for the broader symptomatic ICAS patient population. The rates of recurrent strokes in ICAS patients managed with aggressive MM do not seem to be as high as anticipated. Additional multicenter RCTs including safer devices, larger sample sizes, and patients at higher risk of recurrent events are warranted.
In vitro comparison of manual and robotic endovascular thrombectomy for acute ischemic stroke
Authors: Kaneko Naoki , Beaman Charles , Imahori Taichiro , Takayanagi Ariel , Saber Hamidreza , Tateshima Satoshi 
Published: October 2023

Background Robotic endovascular systems have the potential to reduce radiation exposure to physicians and expand timely neurointerventional access to patients in remote areas. The goal of the study was to determine the feasibility of robotic endovascular thrombectomy (EVT) in an in vitro model. Methods In vitro procedures were conducted manually and robotically using the Corpath GRX robotic system in a human vascular simulator with an elastic ovine clot in the M1 segment of the left middle cerebral artery. Due to the limited device compatibility of the CorPath GRX, a simple technique with a stent retriever and guiding catheter without a balloon was used in the study. Seven robotic EVT and manual EVT were carried out in each group. Metrics including procedural time, success rate, and radiation dose were compared between the two groups. Results In robotic EVT, the mean total preparation and procedural time was 892 s, which was significantly longer than manual operation at 357 (p = 0.0001). There was no significant difference in the success rate between the two approaches (robotic: 28.6% vs. manual 42.9%, p = 0.577). The mean radiation exposure to operating physicians was significantly lower during robotic operation compared to manual operation (0.02 μSv vs. 0.22 μSv, p < 0.0001). Conclusions Robotic EVT was feasible in our human vascular simulator with significantly reduced radiation exposure to the operating physicians, despite an increased length of procedure when compared to manual procedures. Future technological advancement is warranted for reducing procedural length using endovascular robotic techniques.
Health literacy and COVID-19 vaccine acceptance worldwide: A systematic review
Authors: Fenta Eneyew Talie , Tiruneh Misganaw Guadie , Delie Amare Mebrate , Kidie Atitegeb Abera , Ayal Birtukan Gizachew , Limenh Liknaw Workie , Astatkie Beselam Gizachew , Workie Nigus Kassie , yigzaw Zeamanuel Anteneh , Bogale Eyob ketema , Anagaw Tadele Fentabil 
Published: October 2023

Objective: Health literacy helps an individual to have the capacity to obtain, process, and understand basic health information to make appropriate health decisions. This study aimed to review the association between health literacy and COVID-19 vaccine acceptance. Method: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses steps. Databases including PubMed/MEDLINE, Web of Science, Scopus, EMBASE, World Health Organization libraries, and Google Scholar were used to search all published articles in the area of health literacy and COVID-19 vaccine acceptance until August 1, 2022. Result: In this review, 1348 articles were retrieved. Finally, 13 articles were included in the review after the removal of duplicates that did not meet our inclusion criteria. In all, 10 articles showed that health literacy was significantly associated with COVID-19 vaccine acceptance. This review also showed that positive perception of the vaccine, vaccine hesitancy, adverse reaction from vaccines, residence, socioeconomic status, level of education, younger age, being a health worker, and positive belief have associations with health literacy and COVID-19 vaccine acceptance. There was significant heterogeneity in the study population and measurement tools used for health literacy and COVID-19 vaccine acceptance. Conclusion: This systematic review provides comprehensive evidence on health literacy and COVID-19 vaccine acceptance globally. There was significant heterogeneity in the study population and measurement tools used for health literacy and COVID-19 vaccine acceptance. Most studies reported that health literacy is significantly associated with COVID-19 vaccine acceptance. Therefore, investing in health literacy using different vaccine promotion strategies may improve COVID-19 vaccine acceptance and health decision-making to decrease the impact of the COVID-19 pandemic.
Exploring the effectiveness of artificial intelligence, machine learning and deep learning in trauma triage: A systematic review and meta-analysis
Authors: Adebayo Oluwasemilore , Bhuiyan Zunira Areeba , Ahmed Zubair 
Published: October 2023

Background The development of artificial intelligence (AI), machine learning (ML) and deep learning (DL) has advanced rapidly in the medical field, notably in trauma medicine. We aimed to systematically appraise the efficacy of AI, ML and DL models for predicting outcomes in trauma triage compared to conventional triage tools. Methods We searched PubMed, MEDLINE, ProQuest, Embase and reference lists for studies published from 1 January 2010 to 9 June 2022. We included studies which analysed the use of AI, ML and DL models for trauma triage in human subjects. Reviews and AI/ML/DL models used for other purposes such as teaching, or diagnosis were excluded. Data was extracted on AI/ML/DL model type, comparison tools, primary outcomes and secondary outcomes. We performed meta-analysis on studies reporting our main outcomes of mortality, hospitalisation and critical care admission. Results One hundred and fourteen studies were identified in our search, of which 14 studies were included in the systematic review and 10 were included in the meta-analysis. All studies performed external validation. The best-performing AI/ML/DL models outperformed conventional trauma triage tools for all outcomes in all studies except two. For mortality, the mean area under the receiver operating characteristic (AUROC) score difference between AI/ML/DL models and conventional trauma triage was 0.09, 95% CI (0.02, 0.15), favouring AI/ML/DL models ( p = 0.008). The mean AUROC score difference for hospitalisation was 0.11, 95% CI (0.10, 0.13), favouring AI/ML/DL models ( p = 0.0001). For critical care admission, the mean AUROC score difference was 0.09, 95% CI (0.08, 0.10) favouring AI/ML/DL models ( p = 0.00001). Conclusions This review demonstrates that the predictive ability of AI/ML/DL models is significantly better than conventional trauma triage tools for outcomes of mortality, hospitalisation and critical care admission. However, further research and in particular randomised controlled trials are required to evaluate the clinical and economic impacts of using AI/ML/DL models in trauma medicine.
Impact of stroke on people that receive rehabilitation and are living in Ankara, Turkey
Authors: Aran Orkun Tahir , Köse Barkın , Erikson Gunilla , Guidetti Susanne 
Published: October 2023

Background: Clinical guidelines for stroke rehabilitation and practices vary between high and low/middle-income countries (LMICs). Knowledge of the perceived impact of stroke in Turkey is limited. Understanding these perceptions can serve as a basis for developing rehabilitation. Design and methods: The aim was to investigate and compare the perceived impact of stroke in two groups of people living in Ankara. A cross-sectional study with 150 participants divided by stroke onset (Group I: stroke onset <12 months; Group II: >12 months) was conducted. The Barthel Index was used to describe the level of independence in daily living activities and stroke severity. The Stroke Impact Scale (SIS 3.0) was used to investigate the perceived impact of stroke. Results: The proportion of mild strokes was 78 and 82%, respectively, and 46% of participants in the total sample were moderately dependent. The impact of stroke was high; mean domain scores were below 50 in six of the eight SIS domains. Conclusions: Turkish stroke survivors perceived a higher impact of stroke regardless of the time passed since stroke onset, compared to survivors from other countries, including other LMICs. The high impact among survivors with mostly mild stroke indicates that Turkish survivors might not receive adequate rehabilitation. The content of rehabilitation services needs to be developed, and an evaluation of individually tailored interventions, preferably with a multidisciplinary approach, is warranted to find ways to decrease the perceived impact of stroke among Turkish stroke survivors.
Biomedical properties and hemostatic efficacy of polyvinyl alcohol (PVA) based hydrogel in experimental rat liver injury model
Authors: Dorkhani Erfan , Faryabi Ali , noorafkan Yasmin , Heirani Asieh , Behboudi Behnam , Fazeli Mohammad Sadegh , Kazemeini Alireza , Keramati Mohammad Reza , Keshvari Amir , Ahmadi Tafti Seyed Mohsen 
Published: October 2023

Purpose: Bleeding is a leading cause of mortality and morbidity in the trauma and surgery field, using effective hemostatic agents can help us reduce bleeding especially in parenchymal hemorrhage. Nowadays polyvinyl alcohol (PVA) is known as a safe candidate for wound dressing and maybe a hemostatic agent. PVA-based hydrogel is a popular biocompatible material in the biomedical field especially when it has high water absorption. In this study, we investigated the PVA hydrogel’s mechanical and biological properties as well as its hemostatic potential in parenchymal bleeding. Methods: PVA hydrogel had made by the freeze-thawing approach, we used PVA hydrogel in comparison to standard treatment to investigate hemostatic potency. Also, we performed MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) tests to survey PVA cellular toxicity. After an acute liver injury, two groups of 12 rats were treated with PVA hydrogel or standard treatment with sterile gauze. The results including the time and volume of bleeding, and the time and survival rate of the rats were measured and compared. Results: We saw that PVA hydrogel was safe with no cellular toxicity in the MTT assay. Regarding efficacy, PVA hydrogel increased rats’ survival after bleeding from 75% to 91.7%, and decreased bleeding time ( p: 0.015), and bleeding volume ( p: 0.03) compared to the control group. Conclusion: Polyvinyl alcohol is safe. It has good biological properties with no cellular toxicity and has a significant hemostatic effect and can be regarded in control of parenchymal hemorrhage.
Long-Term Outcomes of Primary Hip Arthroscopy With Labral Repair for Femoroacetabular Impingement: Results at Minimum 9-Year Follow-up
Authors: Wang Allen S. , Lamba Abhinav , Okoroha Kelechi R. , Levy Bruce A. , Krych Aaron J. , Hevesi Mario 
Published: October 2023

Background: Hip arthroscopy continues to advance and become increasingly commonly performed. With the evolution of techniques and instrumentation, labral repair rather than debridement has emerged as the treatment of choice for labral pathology. There remains a lack of data on long-term outcomes after labral repair. Purpose: To (1) evaluate long-term patient-reported outcomes of primary hip arthroscopy with labral repair for femoroacetabular impingement, (2) report achievement rates of Patient Acceptable Symptom State (PASS) and minimal clinically important difference (MCID), and (3) investigate rates of reoperation and progression to total hip arthroplasty (THA). Study Design: Case series; Level of evidence, 4. Methods: Prospectively collected data were reviewed for patients who underwent primary hip arthroscopy with labral repair between 2010 and 2013. Patients’ medical records were reviewed for demographic characteristics, intraoperative findings, reoperation, and progression to THA. Patients were assessed pre- and postoperatively using the following scales: visual analog scale (VAS) for pain; Tegner activity scale; modified Harris Hip Score (mHHS); 12-item International Hip Outcome Tool (iHOT-12); Hip Outcome Score–Activities of Daily Living (HOS-ADL); HOS–Sport-Specific Subscale (HOS-SSS); and Non-Arthritic Hip Score. Patients were also surveyed for satisfaction, subjective improvement, and level of function. Results: A total of 32 patients (n = 24 women; n = 8 men) with a mean age of 27.7 years (range, 13.6-51 years) were evaluated for a mean of 9.4 years (range, 9-12.1 years). Patients achieved significant mean improvements in VAS pain at rest of 2 points, VAS pain with use of 1.9, mHHS of 19.9 points, iHOT-12 of 33.5 points, HOS-ADL of 17.4 points, and HOS-SSS of 29.5 points ( P≤ .015 for all). Eleven patients (34.4%) underwent reoperation and 4 (12.5%) progressed to THA during the study period. At the final follow-up, the MCID achievement rate was ≥68%, the PASS achievement rates ranged from 39% to 65%, and the mean patient satisfaction was 8.1 on a 1 to 10 scale, with 10 denoting most satisfied. Conclusion: Patients demonstrated significant postoperative improvements in pain, mHHS, iHOT-12, HOS-ADL, and HOS-SSS scores at 9 years postoperatively. The all-cause reoperation rate was 34.4%, and 12.5% of patients progressed to THA.
Letnikovite-(Ce), (Na□)Ca2Ce2[Si7O17(OH)]F4(H2O)4, a new mineral from the Darai-Pioz alkaline massif, Tajikistan: mineral description, crystal structure and a new single [Si7O17(OH)] sheet
Authors: Agakhanov Atali A. , Sokolova Elena , Cámara Fernando , Karpenko Vladimir Yu. , Hawthorne Frank C. , Pautov Leonid A. , Kasatkin Anatoly V. , Pekov Igor V. , Agakhanova Vitaliya A. 
Published: October 2023

AbstractLetnikovite-(Ce), ideally (Na□)Ca2Ce2[Si7O17(OH)]F4(H2O)4, is a new mineral with no natural or synthetic analogues (IMA2022–132). The mineral occurs at the Darai-Pioz alkaline massif, Tien-Shan mountains, Tajikistan, in a silexite-like peralkaline pegmatite. Letnikovite-(Ce) occurs as isolated prismatic grains up to 0.03 × 0.1 mm in a quartz–pectolite aggregate. Associated minerals are quartz, fluorite, pectolite, baratovite, aegirine, leucosphenite, neptunite, reedmergnerite, orlovite, sokolovaite, mendeleevite-(Ce), odigitriaite, pekovite, zeravshanite, kirchhoffite and garmite. The mineral is colourless with a vitreous lustre and a white streak, and Dcalc. is 2.847 g/cm3. Letnikovite-(Ce) is monoclinic, C2/m, a = 7.4726(3), b = 22.9196(9), c = 13.9360(6) Å, β = 105.550(5)° and V = 2299.43(17) Å3. The chemical composition of letnikovite-(Ce) is SiO2 42.38, Gd2O3 0.16, Eu2O3 0.28, Sm2O3 0.07, Nd2O3 5.64, Pr2O3 1.69, Ce2O3 11.73, La2O3 2.24, PbO 1.22, SrO 5.77, FeO 0.32, CaO 11.87, MgO 1.14, Cs2O 0.57, K2O 0.65, Na2O 2.24, H2O 7.79, F 7.29, O = F –3.07, total 99.98 wt.%. The empirical formula calculated on 7 Si apfu is Na0.72K0.14Cs0.04Ca2.10Sr0.55Mg0.28Pb0.05Fe0.04(Ce0.71Nd0.33La0.14Pr0.10Eu0.02Gd0.01)Σ1.31Si7O21.84F3.81H8.58 for Z = 4. The structural formula is (Na0.72Ca0.16□1.12)Σ2(Cs0.04□0.96)Σ1(Ca1.83□0.17)Σ2(Mg0.28Fe0.04□0.68)Σ1(Ln3+1.31Sr0.55Ca0.09Pb0.05)Σ2[Si7O17(OH)]F3.81(H2O)3.79, where Ln3+1.31 = (Ce0.71Nd0.33La0.14Pr0.10Eu0.02Gd0.01)Σ1.31. The simplified formula is (Na,□)2Ca2(Ln3+,Sr)2[Si7O17(OH)]F4(H2O)4, where Ce is the dominant lanthanoid. The crystal structure was solved by direct methods and refined to an R1 index of 4.2%. In letnikovite-(Ce), the main structural unit is a layer which consists of the central heteropolyhedral Ca–Ce sheet and two adjacent single [Si7O17(OH)] sheets parallel to (001). In the Si–O–OH sheet, the Si tetrahedra form five-membered and ten-membered rings. This is the first occurrence of a single [Si7O17(OH)]7– sheet in a mineral. The layers connect via Na and Cs at the interstitial A(1,2) sites, H2O groups and hydrogen bonding. The mineral is named in honour of Felix Artem'evich Letnikov (born October 3rd,1934) in recognition of his outstanding contributions to the field of petrology and geochemistry of Precambrian rocks.
Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages
Authors: Ling Zhengyi , Li Jingrui , Dong Yanmei , Zhang Wenying , Bai Hongtong , Li Shu , Wang Su , Li Hui , Shi Lei 
Published: October 2023

AbstractTo deter herbivore attacks, plants employ a diverse array of volatile compounds, particularly during the early developmental stages. The highly expressed genes LaTPS7, LaTPS8, and LaCYP71D582 were identified during the budding phases of Lavandula angustifolia. In vitro studies revealed that LaTPS7 generated nine distinct compounds, including camphene, myrcene, and limonene. LaTPS8 enzymatically converted eight volatiles by utilizing geranyl diphosphate and nerolidyl diphosphate as substrates. Overexpression of plastid-localized LaTPS7 in Nicotiana benthamiana resulted in the production of limonene. Furthermore, the endoplasmic reticulum-associated enzyme LaCYP71D582 potentially converted limonene into carveol. In N. benthamiana, LaTPS8 is responsible for the synthesis of α-pinene and sylvestrene. Furthermore, leaves transfected with LaTPS7 and leaves cotransfected with LaTPS7 and LaCYP71D582 exhibited a repellent effect on aphids, with an approximate rate of 70%. In comparison, leaves with an empty vector displayed a repellent rate of approximately 20%. Conversely, tobacco leaves expressing LaTPS7 attracted ladybugs at a rate of 48.33%, while leaves coexpressing LaTPS7 and LaCYP71D582 attracted ladybugs at a slightly higher rate of 58.33%. Subsequent authentic standard tests confirmed that limonene and carveol repel Myzus persicae while attracting Harmonia axyridis. The promoter activity of LaTPS7 and LaCYP71D582 was evaluated in Arabidopsis thaliana using GUS staining, and it was observed that wounding stimulated the expression of LaTPS7. The volatile compounds produced by LaTPS7, LaTPS8, and LaCYP71D582 play a crucial role in plant defence mechanisms. In practical applications, employing biological control measures based on plant-based approaches can promote human and environmental health.
Association between ankle-brachial blood pressure index with all-cause and cardiovascular mortality in adults without arterial stiffness
Authors: Meng Zhe , Jiang Yaohui , Xu Chang , Zheng Huifen , Li Haiyu 
Published: October 2023

Abstract
Purpose
To explore the relationship between ankle-brachial blood pressure index (ABPI) and all-cause or cardiovascular mortality in adults without arterial stiffness.

Methods
A total of 6784 participants without arterial stiffness were enrolled from National Health and Nutrition Examination Survey 1999–2004. The hazard ratio (HR) and 95% confidence interval (CI) of ABPI associating with the risk of all-cause and cardiovascular mortality was calculated by Cox proportional regression models adjusted for demographic and traditional risk factors. Dose-response relationship was explored with restricted cubic spines.

Results
After an average follow-up of 12.1 years, 1844 all-cause deaths and 299 cardiovascular deaths occurred. Compared with the lowest ABPI quartile, the second quartile was associated with the lowest risk of all-cause mortality (HR 0.89, 95%CI 0.79–0.98; p = 0.036) and cardiovascular mortality (HR 0.75, 95%CI 0.56–0.98; p = 0.048). Besides, dose-response analysis revealed that ABPI was nonlinearly correlated to all-cause mortality (p for nonlinearity < 0.001) and linearly correlated to cardiovascular mortality (p for nonlinearity = 0.459).

Conclusions
The relationship between ABPI and all-cause and cardiovascular mortality followed a L-shape curve. A lower ABPI was independently associated with an increased risk of all-cause and cardiovascular mortality in adults without arterial stiffness.