bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and application of the environment evaluation model for beneficiation plant
Authors: Liu Houdong , Kang Qian , Zhao Kui , Ke Yuxian , Yu Songtao 
Published: February 2024

Abstract

In order to evaluate the environment of beneficiation plant in a more scientific and reasonable way, this project took the workshop environment of beneficiation plant as the research object. This project divided the beneficiation plant into 7 evaluation units according to their functions. The evaluation indexes are dust, noise, light environment, microclimate, benzene, toluene and xylene. This project combined G1 method and entropy weight method to evaluate the weight of each evaluation index, the element extension model of the working environment of the concentrator is established by element analysis method, and the matter element analysis method is used to establish an evaluation index system of a beneficiation plant in East China. The results show that the evaluation level of the breaking workshop and the auxiliary facilities are unqualified, the auxiliary facility is qualified, the culling workshop, culled yard and accessory building are medium, the screening workshop and grinding workshop are good.
A rare case of Posterior dislocation of hinge knee prosthesis due to wear of Anti-luxation device: A case report
Authors: Somani Vasav , Shaikh Ashraf , Desai Mohan , Karwande Nikhil 
Published: February 2024

Abstract

Interference in the normal framework of knee anatomy distorts its intrinsic stability. This interference can be in variable form such as bone deficiency, infection, multiple revision surgeries, ligamentous laxity. Restoration of intrinsic stability in today's world has been made possible by a highly constraint, hinged knee prosthesis. Although there have been positive results in the form of patient satisfaction and knee society scores reported with these prostheses, long-term follow-up is limited, and complications such as infection, periprosthetic fractures and aseptic loosening have been reported. We report one such rare complication of posterior dislocation of hinged knee prosthesis due to wear of anti-luxation device.
Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation
Authors: Cho Inchul , Xu Jessie , Aziz Hafsah , Lui Prudence , Xie Boyu , Tsai Pei-Hsun , Jeon Hee-Yeon , Choi Jinwook , Ali Shahnawaz , Ali Niwa 
Published: February 2024

Abstract
The maintenance of adult tissue homeostasis is dependent on the functional cross-talk between stem cells (SCs) and tissue-resident immune cells. This reciprocal relationship is also essential for tissue organogenesis during early life. The skin harbors a relatively large population of Regulatory T cells (Tregs) that accumulate within the first two weeks after birth. A functional role for early skin seeding Tregs (ETregs) during the first week of life is currently unexplored. Here, we show that skin Tregs are detected early as postnatal day 3 (P3) where they localize to hair follicle (HF) structures and enter a dynamic flux of activation marker expression. Punctual ETreg depletion from P6-P8, but not later, results in defective HF melanocyte SC (MeSC) mediated skin pigmentation in juvenile life. Transcriptomic analysis of the whole skin on P9 exhibited immediate and pronounced changes in MeSC markers and perturbation of Peroxisome proliferator-activated receptor-γ (PPARγ) target genes in the HF. Accordingly, punctual ETreg depletion combined with short-term PPARγ agonization restored skin pigmentation. Single cell profiling of P9 skin revealed that PPARγsignalling activity is preferentially diminished in the HF epithelium upon loss of ETregs. Finally, we explored changes in the single cell transcriptome of the human tissue disorder, vitiligo, characterized by a lack of melanin and consequent skin depigmentation. These analyses showed that the HF cells from lesional vitiligo skin exhibited a significant downregulation in PPARγ pathway activation, relative to heathy controls. Overall, ETregs in neonatal skin are critical for sustaining HF PPARγ signaling, which is vital for facilitating MeSC mediated skin pigmentation during postnatal development.
One Sentence Summary: PPARγ pathway functions downstream of neonatal Tregs to regulate melanocyte stem cell function.
Dietary lipid is largely deposited in skin and rapidly affects insulating properties
Authors: Riley Nick , Kasza Ildiko , Barrett-Wilt Greg , Michaud Julian , Jain Raghav , Trautman Michaela E. , Simcox Judith A. , Yen Chi-Liang E. , MacDougald Ormond A. , Lamming Dudley W. , Alexander Caroline M. 
Published: February 2024

Abstract

Skin has been shown to be a regulatory hub for energy expenditure and metabolism: mutations of skin lipid metabolism enzymes can change the rate of thermogenesis and susceptibility to diet-induced obesity. However, little is known about the physiological basis for this function. Here we show that the thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We found that skin was the largest target in a mouse body for dietary fat delivery, and that fat was assimilated both by epidermis and by dermal white adipose tissue. Dietary triglyceride acyl groups persist in skin for weeks after feeding. Using multi-modal lipid profiling, we have implicated both keratinocytes and sebocytes in the altered lipids which correlate with thermal function. In response to high fat feeding, wax diesters and ceramides accumulate, and triglycerides become more saturated. In contrast, in response to the dramatic loss of adipose tissue that accompanies restriction of the branched chain amino acid isoleucine, skin becomes highly heat-permeable: skins shows limited uptake of dietary lipids and editing of wax esters, and acquires a signature of depleted signaling lipids, which include the acyl carnitines and lipid ethers. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality.
Pulmonary complications and mortality among COVID-19 patients undergoing a surgery: a multicenter cohort study
Authors: Amzallag Éva , Panchadsaram Thanushka , Lecluyse Vincent , Couture Etienne J. , D’Aragon Frédérick , Kandelman Stanislas , Turgeon Alexis F. , Jodoin Caroline , Girard Martin , Beaulieu Pierre , Richebé Philippe , Carrier François Martin 
Published: February 2024

Abstract

Background
Managing COVID-19-positive patients requiring surgery is complex due to perceived heightened perioperative risks. However, Canadian data in this context remains scarce. To address this gap, we conducted a multicenter cohort study in the province of Québec, the Canadian province most affected during the initial waves of the pandemic, to comprehensively assess the impact of COVID-19 symptoms, and recovery time, on postoperative outcomes in surgical patients.
Methods
We included adult surgical patients with either active COVID-19 at time of surgery or those who had recovered from the disease, from March 13, 2020, to April 30, 2021. We evaluated the association between symptoms or recovery time and postoperative pulmonary complications and hospital mortality using multivariable logistic regression and Cox models.
Results
We included 105 patients with an active infection (47 were symptomatic and 58 were asymptomatic) and 206 who had healed from COVID-19 in seven hospitals. Among patients with an active infection, those who were symptomatic had a higher risk of pulmonary complications (odds ratio = 3.19; 95% CI, from 1.12 to 9.68; p = 0.03) and hospital mortality (hazard ratio = 3.67; 95% CI, from 1.19 to 11.32; p = 0.02). We did not observe any significant effect of the duration of recovery prior to surgery on patients who had healed from their infection. Their postoperative outcomes were also similar to those observed in asymptomatic patients.
Interpretation
Symptomatic status should be considered in the decision to proceed with surgery in COVID-19-positive patients. Our results may help optimize surgical care in this patient population.
Trial registration:
ClinicalTrials.gov Identifier: NCT04458337, Registration Date: July 7, 2020.
Evaluation of the Impact of Temperature and pooling sample to Detect and Isolate the Major Escherichia coli Serogroups Producing Shiga toxin with alternative and standard methods
Authors: BOUVIER Marion , Thollet Camille , Douellou Thomas , Sergentet Delphine Thevenot 
Published: February 2024

Abstract
Pathogenic shiga toxin-producing Escherichia coli (STEC) are an important cause of food-borne illness. The detection of STECs in finished products and during the manufacturing process has an important role as part of verification plans, to confirm that practices and procedures described in the food safety program are successful applied to control STEC. The aim of this study is to examine the impact of increasing the enrichment temperature (from 37°C to 41.5°C) and the feasibility of pooling for the detection of “Top6", non-O157, samples in raw meat products. Both ISO TS 13 136:2012 and a novel alternative method were implemented to evaluate the impact of those new parameters. An increase of the enrichment temperature to 41.5°C allowed the detection of the spiked strain for 10% more samples compared to enrichment at 37°C. The realization of analysis by pooling the samples is compatible with the two methods used. Among the 220 food enrichments analyzed, faster results were obtained by the alternative method described in this work than by the ISO/TS 13 136 reference method. Our study showed that both methods allowed the detection and isolation of STEC strains from food enrichments.
Evaluation of climate change and land-use impacts on groundwater dynamics in the Bari Doab Canal System
Authors: Haider Saif , Rashid Muhammad , Saleem Jawad 
Published: February 2024

Abstract
Globally, groundwater depletion has grown to be a serious issue, as land and water resources have been gravely exhausted due to the rising population's desire for food and water. The current research evaluated the decline in groundwater caused by land use and climate change in the Bari Doab Canal, Pakistan utilizing the latest Coupled Model Intercomparison Project (CMIP6) collection of several global climate models (GCMs). Cellular Automata Markov Chain model was used to create LULC maps of 2030, 2060, and 2100 by analyzing the changes based on satellite imagery gathered in 2000, 2010, and 2020. Groundwater extraction was estimated through the deficit of effective rainfall and net canal water use from evapotranspiration after compensating soil moisture storage changes. GCM projected rainfall and temperature under two Shared Socioeconomic Pathways (SSPs) SSP2 and SSP5 was downscaled using the CMhyd model till the end of the twenty-first century. The precipitation, maximum and minimum temperatures, and crop water requirements were anticipated to increase by downscaled projections of a selected model (MPI-ESM1-2-HR) till the end of the twenty-first century compared to the baseline period (1981–2020). The groundwater table had dropped by 0.62 meters annually through 16 years (2005–2020). The model simulated outcomes demonstrated the detrimental effects of the expected changes in land use and climate on the groundwater in Bari Doab. This study supports the development of appropriate adaptation measures by policymakers and stakeholders to mitigate the detrimental impacts of climate and land use change on groundwater dynamics.
Enhancement of technical, economic and environment Benefits of PQ disturbances in Grid connected system using fuzzy logic based IUPQC
Authors: Fangzong Wang , Nishtar Zuhaib 
Published: February 2024

Abstract

Maintaining peak performance in modern power systems while dealing with power quality disturbances (PQDs) is no easy feat. This study suggests a new way to improve grid-connected systems' technical, economic, and environmental benefits during PQDs by using an Interline Unified Power Quality Conditioner (IUPQC) based on fuzzy logic. The research uses state-of-the-art methods that incorporate fuzzy logic control into the IUPQC framework to reduce voltage sag, swell, flicker, harmonics, and interruptions, among other PQDs. Considering the nonlinear and ever-changing character of PQDs, fuzzy logic is an excellent choice for a control mechanism because of its resilience and adaptability in the face of uncertain and imprecise input. The IUPQC detects and responds to PQDs by analyzing system conditions and adjusting its operation with the use of fuzzy logic-based control algorithms. An advanced power conditioning device in and of itself, the IUPQC can mitigate numerous PQDs at various points in the power distribution system all at once. The IUPQC outperforms and provides more flexibility than traditional power quality mitigation devices by combining shunt active power filters with series filters. The research models the grid-connected system and simulates various PQDs situations using powerful simulation tools like MATLAB/Simulink. Furthermore, experimental validation is carried out using real-world hardware configurations to confirm the efficacy and practicability of the suggested fuzzy logic-based IUPQC in reducing PQDs in real-world operating scenarios. Field implementation and case studies, environmental effect assessment, multi-objective optimization, and comparison analysis will all be further explored in the revised and expanded edition of this project. The fuzzy logic-based IUPQC will be compared to other methods for reducing PQDs, including active power filters, passive filters, and traditional IUPQC, to show how much better it is and how much less expensive it is. In addition, we will evaluate fuzzy logic-based control parameters of the IUPQC using multi-objective optimization approaches. These techniques consider conflicting objectives such minimizing system losses, maximizing power quality improvement, and decreasing operational expenses. Reducing emissions of greenhouse gases, conserving energy, and improving sustainability are just a few of the environmental benefits that an extensive environmental impact assessment will identify. Lastly, case studies and real-world implementation will show how the fuzzy logic-based IUPQC works in various real-world settings, shedding light on its advantages like lower downtime, better power quality, and cost savings for both power utilities and end users.
Stigmasterol mitigates rheumatoid arthritis progression by decreasing Nrf2/NLRP3-mediated pyroptosis in chondrocyte
Authors: Ding Li , Xiao Lianbo , Lin Huijun , He Yong , Ding Sheng , Zhang Jiechao 
Published: February 2024

Abstract
Background
Rheumatoid arthritis (RA) is a long-lasting inflammatory joint disorder characterized by joint swelling, stiffness, pain, and loss of function in joints. Chondrocyte inflammation and apoptosis are closely associated with cartilage destruction. Stigmasterol (Stig) is a phytosterol with anti-inflammatory and anti-oxidant effects. In the study, we aimed to investigate whether Stig mitigates RA progression by decreasing chondrocyte injury.
Methods and Results
A mouse RA model was established by injecting intradermally type Ⅱ collagen into the tail roots of mice. Arthritic score and spleen index were measured in RA mice to assess the effects of Stig on RA progression. Lipopolysaccharide (Lps)-treated chondrocytes were applied as the cell model of RA. The roles of Stig in chondrocyte viability, proliferation, migration, inflammation, and injury were tested using cell counting kit-8 (CCK-8), EdU, transwell, quantitative real-time PCR (qRT-PCR), and western blot assays, respectively. Our results demonstrated that Stig exhibited no significant cytotoxicity against CHON-001 chondrocytes, but Stig effectively inhibited Lps-induced decreases in cell viability, proliferation, and migration. Stig also alleviated Lps-evoked pro-inflammatory responses and CHON-001 cell injury. Mechanistically, Stig inhibited Lps-induced nuclear factor erythroid 2-related factor 2 (Nrf2) activation and subsequent NOD-like receptor protein 3 (NLRP3) inflammasome activation, resulting in CHON-001 pyroptosis. Nigericin, a NLRP3 activator, reversed the effects of Stig on mitigating CHON-001 cell injury. Furthermore, the clinical severity in RA mice was improved after Stig treatment.
Conclusions
In summary, Stig decreases Lps-induced chondrocyte injury and mitigates RA progression by inhibiting Nrf2/NLRP3-mediated pyroptosis, thereby providing the opportunity to treat RA.
Recommendations for digital sharing of notes with adolescents in mental health care: a Delphi study
Authors: Nielsen Martine Stecher , Steinsbekk Aslak , Nøst Torunn Hatlen 
Published: February 2024

Abstract
Introduction: In many countries, healthcare professionals are legally obliged to share information from electronic health records with patients. However, concerns have been raised regarding the sharing of notes with adolescents in mental health care, and healthcare professionals have called for recommendations to guide this practice. Therefore, the aim was to reach a consensus among authors of scientific papers on recommendations for healthcare professionals’ digital sharing of notes with adolescents in mental health care. In addition, to describe whether staff at child and adolescent specialist mental healthcare clinics agreed with the recommendations.
Methods: A Delphi study was conducted with authors of scientific papers to reach a consensus on recommendations. Additionally, a cross-sectional study was conducted among staff at the specialist child and adolescent mental healthcare clinics to assess whether they agreed with the recommendations that reached a consensus.
Results: Twenty-seven of the 84 invited authors responded. A consensus was achieved on 17 recommendations on central areas related to the digital sharing of notes with adolescents in mental health care. The recommendations considered how to introduce digital access to notes, write notes, support healthcare professionals, and when to withhold notes. Sixty percent or more of the 41 staff members at child and adolescent specialist mental healthcare clinics agreed with the 17 recommendations.
Conclusion: Seventeen recommendations for healthcare professionals’ digital sharing of notes with adolescents in mental health care were established through a Delphi study and supported by staff at child and adolescent specialist mental healthcare clinics. Healthcare professionals can use these recommendations to guide their practice of sharing notes with adolescents in mental health care.
Harmonic Mitigation of the Microgrid Using Multi Hidden Layer Recurrent Neural Network Controlled SAPF
Authors: P Divya Banu. , Sundar G 
Published: February 2024

Abstract

Recently, renewable energy systems are more prevalent than traditional energy systems. Especially, Photovoltaic (PV) systems and wind power systems are playing an important part in meeting the world's energy needs. The present needs of more nonlinear loads drastically create power quality issues in the grid-connected system. As a result, it causes an undesired power quality defect that takes the manner of an alteration in the amplitude and patterns of voltage and current in the power system. The shunt active power filter (SAPF) delivers the appropriate current in shunt to grids while suppressing harmonics created by grid-tied nonlinear loads. This paper proposes a multi hidden layer recurrent neural network (RNN) controller for the developing a reference signal in synchronous reference frame theory. RNN is proposed for its high efficacy compared to neural networks, due to self-loops and memory. The effectiveness of the proposed multi-hidden layer RNN-based SAPF system is compared with the performance of neural networks and traditional PI controller-based SAPF systems in terms of harmonic mitigation. Effective harmonic mitigation by proposed multi-hidden layer RNN results current THD of proposed microgrid to 1.74%.
Clinical Value of Microsurgery Combined with Covering New Urethra by Multilayer Sarcolemma Tissues in the Treatment of Hypospadias in Male Children and Analysis of Urodynamic Parameters
Authors: Zheng Wei , Guo Shi-lei , Shi Xiao-qing , Wang Jie , Zhang Bo-song , Li Li-wei , Liu Chuang , Yang Bin 
Published: February 2024

Abstract
Objective
To compare and analyze differences in the clinical effect and postoperative urodynamic indexes of microsurgery combined with covering new urethra by multilayer sarcolemma tissues and conventional surgery alone in the treatment of male children with hypospadias.
Methods
A total of 80 male children with penile hypospadias who were hospitalized in Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital were randomly divided into two groups, with 40 in each group. Children in the study group underwent microsurgery combined with covering new urethra by multilayer sarcolemma tissues, while those in the control group were provided with traditional tubularized incised plate (TIP) urethroplasty alone. Further comparative analysis was performed on the operation effect, operation time, total intraoperative bleeding, postoperative length of stay in the hospital and the incidence of surgical complications between the two groups. All male children were followed up for 6 months to compare and analyze the changes of urodynamic parameters such as maximum urinary flow rate (Qmax), mean urinary flow rate (Qavc), post-void residual urine (PVR) before and after surgery.
Results
There were statistically significant differences that the operation time(p = 0.03) was longer while the postoperative length of stay in the hospital (p = 0.000) was shorter in the study group than those in the control group. The effective rate of the study group was 97.50%, while that of the control group was 82.50%, with statistically significant difference (p = 0.025). The incidence of surgical complications was 7.50% in the study group and 25.00% in the control group 3 months after operation (p = 0.034). There was statistically significant difference that the Hose score of the study group was significantly higher than that of the control group (p = 0.000). Meanwhile, there was no significant difference in indicators such as Qmax, Qavc and PVR between the two groups before surgery; while the levels of Qmax and Qavc in the study group were higher than those in the control group 6 months after surgery, with statistically significant difference (p = 0.000).
Conclusion
Microsurgery combined with covering new urethra by multilayer sarcolemma tissues has certain clinical value in the treatment of male children with hypospadias, which shows good therapeutic effect, shorter length of stay in the hospital, lower incidence of postoperative complications, and significantly improved urodynamic indicators, despite slightly complicated operation and relatively longer duration of operation.