bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis
Authors: Allen-Gondringer Abigail , Gau David , Dutta Partha , Roy Partha 
Published: December 2023

AbstractActin cytoskeleton plays an important role in various aspects of atherosclerosis, a key driver of ischemic heart disease. Actin-binding protein Profilin1 (Pfn1) is overexpressed in atherosclerotic plaques in human disease, and Pfn1, when partially depleted globally in all cell types, confers atheroprotectionin vivo. This study investigates the impact of endothelial cell (EC)-specific partial loss of Pfn1 expression in atherosclerosis development. We utilized mice engineered for conditional heterozygous knockout of the Pfn1 gene in ECs, with atherosclerosis induced by depletion of hepatic LDL receptor by gene delivery of PCSK9 combined with high-cholesterol diet. Our studies show that partial depletion of EC Pfn1 has certain beneficial effects marked by dampening of select pro-atherogenic cytokines (CXCL10 and IL7) with concomitant reduction in cytotoxic T cell abundance but is not sufficient to reduce hyperlipidemia and confer atheroprotectionin vivo. In light of these findings, we conclude that atheroprotective phenotype conferred by global Pfn1 haplo-insufficiency requires contributions of additional cell types that are relevant for atherosclerosis progression.
A niche-derived non-ribosomal peptide triggers planarian sexual development
Authors: Issigonis Melanie , Browder Katherine L. , Chen Rui , Collins James J. , Newmark Phillip A. 
Published: December 2023

AbstractGerm cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (nrps). Inhibitingnrpsled to loss of female reproductive organs and testis hyperplasia. Mass spectrometry detected the dipeptide β-alanyl-tryptamine (BATT), which is associated with reproductive system development and requiresnrpsand a monoamine-transmitter-synthetic enzyme (AADC) for its production. Exogenous BATT rescued the reproductive defects afternrpsoraadcinhibition, restoring fertility. Thus, a non-ribosomal, monoamine-derived peptide provided by niche cells acts as a critical signal to trigger planarian reproductive development. These findings reveal an unexpected function for monoamines in niche-germ cell signaling. Furthermore, given the recently reported role for BATT as a male-derived factor required for reproductive maturation of female schistosomes, these results have important implications for the evolution of parasitic flatworms and suggest a potential role for non-ribosomal peptides as signaling molecules in other organisms.
Improving population scale statistical phasing with whole-genome sequencing data
Authors: Wertenbroek Rick , Hofmeister Robin J. , Xenarios Ioannis , Thoma Yann , Delaneau Olivier 
Published: December 2023

AbstractHaplotype estimation, or phasing, has gained significant traction in large-scale projects due to its valuable contributions to population genetics, variant analysis, and the creation of reference panels for imputation and phasing of new samples. To scale with the growing number of samples, haplotype estimation methods designed for population scale rely on highly optimized statistical models to phase genotype data, and usually ignore read-level information. Statistical methods excel in resolving common variants, however, they still struggle at rare variants due to the lack of statistical information. In this study we introduce SAPPHIRE, a new method that leverages whole-genome sequencing data to enhance the precision of haplotype calls produced by statistical phasing. SAPPHIRE achieves this by refining haplotype estimates through the realignment of sequencing reads, particularly targeting low-confidence phase calls. Our findings demonstrate that SAPPHIRE significantly enhances the accuracy of haplotypes obtained from state of the art methods and also provides the subset of phase calls that are validated by sequencing reads. Finally, we show that our method scales to large data sets by its successful application to the extensive 3.6 Petabytes of sequencing data of the last UK Biobank 200,031 sample release.
The impact of digital supply chain announcements disclosing corporate social responsibility information on stock market value
Authors: Liu Weihua , Liu Tingting , Tang Ou , Lee Paul Tae Woo , Chen Zhixuan 
Published: December 2023

PurposeUsing social network theory (SNT), this study empirically examines the impact of digital supply chain announcements disclosing corporate social responsibility (CSR) information on stock market value.Design/methodology/approachBased on 172 digital supply chain announcements disclosing CSR information from Chinese A-share listed companies, this study uses event study method to test the hypotheses.FindingsFirst, digital supply chain announcements disclosing CSR information generate positive and significant market reactions, which is timely. Second, strategic CSR and value-based CSR disclosed in digital supply chain announcements have a more positive impact on stock market, however there is no significant difference when the CSR orientation is either towards internal or external stakeholders. Third, in terms of digital supply chain network characteristics, announcements reflecting higher relationship embeddedness and higher digital breadth and depth lead to more positive increases of stock value.Originality/valueFirst, the authors consider the value of CSR information in digital supply chain announcements, using an event study approach to fill the gap in the related area. This study is the first examination of the joint impact of digital supply chain and CSR on market reactions. Second, compared to the previous studies on the single dimension of digital supply chain technology application, the authors innovatively consider supply chain network relationship and network structure based on social network theory and integrate several factors that may affect the market reaction. This study improves the understanding of the mechanism between digital supply chain announcements disclosing CSR information and stock market, and informs future research.
“Respect my authority”: spiritual self-managed teams and holacracy
Authors: Gupta Abhishek , Jena Lalatendu Kesari 
Published: December 2023

PurposeThis paper aims to introduce two draft concepts, spiritual self-managed teams and holacracy, as solutions for reducing the friction within neo-enterprises and the issues of hierarchical leadership dynamics and mindset present within orthodox organizations’ structures and communications and they help businesses to grow further, achieve their goals, and become self-sustainable.Design/methodology/approachTo counter the popular maxim, “management and leadership are what cause many problems for organizations and its people,” the authors argue for six novel propositions constructed around the two draft concepts following a critical review and meta-analysis of notable business/leadership cases, presented in a narrative-based descriptive style.FindingsThis article presents a list of novel propositions for entrepreneurs, managers and researchers who may investigate further and possibly test it in organizations. The findings merit opening new frontiers for perceiving leadership, group dynamics and decision-making in organizations using spiritual ideas.Originality/valueAdopting the paper’s content can benefit organizations’ management, efficiency and sustainability. Implementation of the two novel concepts – spiritual self-managed teams and holacracy – and their combination can significantly reduce friction within organizations’ structures and communications.
Gamma-aminobutyric acid enrichment optimized methods in probiotics foods: a systematic review
Authors: Zamanpour Setayesh , Bakhtiari Jami Pardis , Afshari Asma 
Published: December 2023

Purpose
Gamma-aminobutyric acid (GABA) is a four-carbon and nonprotein amino acid, made by various microorganisms, especially lactic acid bacteria (LAB) and probiotics. GABA has various physiological roles, for instance, insomnia, depression, hypotensive activity as well as diuretic effects. The production of GABA-based foods is a favorable result from GABA’s biological and functional properties. The purpose of this study is to investigate different methods of improving GABA production in probiotics and LAB to select the superlative method and bacterial strain.

Design/methodology/approach
In this review paper, all articles from five electronic databases containing Google Scholar, Web of Science, PubMed, Scopus and Science Direct were considered from 2000 to January 11, 2023, with keywords “Optimization” OR “Enhance” OR “Increase” AND “Gamma-aminobutyric acid” OR “GABA” AND “Probiotics” OR “Lactic acid bacteria” and selected according to the purpose of the study.

Findings
It seems that among all the investigated methods, an effective fermentation procedure with optimal conditions including fermentation medium, 5 L; glutamic acid, 295 g/L; incubation temperature, 32°C; inoculum, 10% (v/v); and agitation, 100 rpm, after 48 h of fermentation led to producing 205,800 mg/L of GABA from the effective bacterial strain Lactobacillus brevis NCL912.

Originality/value
With a simple but optimized fermentation, L. brevis NCL912 can be used for the efficient GABA production in the pharmacy and food factories.
Public participation in the social sustainability evaluation of smart city infrastructure in the context of big data: a critical review
Authors: Li Hongyang , Xue Anjie , Zheng Junwei , Skitmore Martin , Moorhead Matthew 
Published: December 2023

Purpose The current booming development of smart cities poses new requirements and challenges for their internal infrastructure development. This article aims to explore the questions of: What is the level of social sustainability of smart city infrastructure today? and What are the core contents and paths to improve this level?Design/methodology/approachWith the theme of public participation in the social sustainability evaluation of smart city infrastructure in the context of big data, this study mainly makes a systematic literature review of the Web of Science's Science Citation Index Expanded and Social Sciences Citation Index databases. After collection and screening, 199 documents were finally obtained.FindingsIt is found that the level of social sustainability of smart city infrastructure is still low, and public participation can provide solutions to the difficulties and challenges involved in its development, while big data technology can broaden the channels for public participation and promote the development of smart city-related components in the process, including smart city infrastructure.Originality/valueThis article summarizes the internal mechanisms of smart cities at the theoretical level and analyzes the social sustainable development of smart city infrastructure. In practice, the shortcomings in this field are identified and suggestions are provided on how to carry out digital public participation, which has practical reference value.
Identification of bioactive compounds from onion (Allium burdickii) bulb using Raman, and FTIR spectroscopy
Authors: Agulei Karen Desta , Githaiga John T. , Dulo Benson , Nganyi Eric Oyondi 
Published: December 2023

PurposeThis study aims to identify the bioactive compounds in the Onion (Allium burdickii[A.B]) bulb using Raman and Fourier transform infrared spectroscopy (FTIR) spectroscopy. It assessed the extraction conditions of bioactive compounds from A.B. while evaluating the best extraction conditions.Design/methodology/approachThe research opted for an experimental qualitative approach. It examined the extraction conditions of A.B., namely, temperature (°C), time (min) and mass-to-liquor ratio (M:R) using ultraviolet-visible spectrophotometry. Identification of bioactive compounds present in the dye was performed using Raman spectroscopy and the validation of the results was done by FTIR spectroscopy.FindingsThe study determined the best extraction conditions (time, temperature, M:R) for A.B bulb. The study confirmed the presence of bioactive compounds.Research limitations/implicationsThe limitation was quantification of bioactive compounds in A.B bulb.Practical implicationsThe findings prove that the A.B. bulb can provide a sustainable source of bioactive compounds (functionalized compounds). The study provides suitable extraction conditions for A.B. and further elaborates on the techniques for identifying bioactive compounds in A.B. bulb extracts.Social implicationsThe study provides A.B. as a source of bioactive compounds and a clean dye for textile coloration.Originality/valueTo the best of the authors’ knowledge, there is no documented study on the qualitative analysis of bioactive compounds in A.B using Raman and FTIR. Therefore, the study fulfils the identified need to ascertain alternative procedures for the analysis of bioactive compounds.
Mind the gap! Factors that predict progression to bariatric surgery indicate that more psychological treatment may be required
Authors: Johnston Lynne , Jackson Kacey , Hilton Charlotte , N H Graham Yitka 
Published: December 2023

SummaryIn the UK, the number of adults living with obesity is increasing. Bariatric surgery is an available treatment for those living with a BMI (kg/m2) ≥40 and above, or ≥35 with obesity‐related comorbidities. Guidelines highlight the importance of providing psychological support pre‐ and post‐surgery owing to the complex psychopathology present in those living with obesity. There are a lack of studies examining which patients proceed to surgery and the factors that predict progression. Routine patient data were collected within one NHS regional service in the UK, comprising 733 patients between 3 August 2018 and 26 July 2019, aged between 17 and 76 years (M = 43.20, SD = 12.32). The only exclusion criteria were patients still awaiting a final decision for surgical outcome at the point of analysis (N = 29), which resulted in 704 patients included in analysis. Binary Logistic Regression revealed those who were more likely to progress to surgery had a lower‐level use of maladaptive external substances; lower level of self‐harm and/or suicidality, were older in age; had a lower BMI; and had less comorbidities than those who did not progress. Findings support existing literature in that bariatric patients often present with physical and mental health complexity. Two thirds of patients in this study did not progress to surgery. Service commissioning decisions meant that these patients did not have access to psychology treatment. Consequently, in cases where bariatric surgery is considered, a final treatment option and otherwise clinically appropriate, lack of access to specialist services may result in unmet patient need owing particularly to a lack of psychological treatment provision.
High‐entropy (Ti0.2V0.2Nb0.2Mo0.2W0.2)Si2 with excellent high‐temperature wear resistance
Authors: Li Jicheng , Chen Shuna , Fan Hengzhong , Zhang Qiangqiang , Su Yunfeng , Song Junjie , Hu Litian , Zhou Yanchun , Zhang Yongsheng 
Published: December 2023

AbstractThe oxidation products (MoO3 and V2O5) have low melting points and tend to sublimate at high temperatures despite that MoSi2 and VSi2 may possess good self‐lubricating properties. To cope with this challenge, a high‐entropy transition metal disilicide was designed in this work in which transition metal elements that could form high melting point oxides were deliberately added. The high‐entropy (Ti0.2V0.2Nb0.2Mo0.2W0.2)Si2 (HE‐MSi2) with hexagonal structure was successfully prepared by SPS using Ti, V, Nb, Mo, W, and Si powders as the initial materials in this work. The HE‐MSi2 presents a high hardness (11.8 ± 0.4 GPa) and elastic modulus (387.2 ± 46.8 GPa). In particular, its hardness is higher than that of the corresponding disilicides. Noteworthy, HE‐MSi2 demonstrated superior wear resistance when compared to Mo‐Si‐based ceramics (such as MoSi2, Mo5Si3, and Mo5SiB2), high‐entropy carbides (such as (MoTaWVTi)C, (HfMoNbTaTi)C, and (TiVNbMoW)4.375, and traditional single‐phase ceramics (including Sialon, Si3N4, Al2O3, SiC, and ZrO2). Meanwhile, at a high temperature of 600°C, the friction coefficient and wear rate were reduced to 0.64 ± 0.05 and (1.88 ± 0.15)×106 mm3/N·m, respectively. The preferential oxidation of different elements of the HE‐MSi2 was validated through systematical characterization of composition evolution, which was dominantly impacted by high temperature and friction induction.
Decision‐making for thrips control in soybean fields using precision agriculture principles
Authors: Santos Juliana L. , Pereira Poliana S. , Reis Kayo H. B. , Freitas Damaris R. , Picanço Filho Marcelo C. , Peluzio Joenes M. , Sarmento Renato A. , Guedes Raul N. C. , Picanço Marcelo C. 
Published: December 2023

AbstractIn precision agriculture, sub‐areas of fields with similar features are called management zones and the inputs applied similarly in these zones. Such notion of management zones is applicable to high‐output soybean fields where thrips are an emerging problem leading to losses up to 15%. Management zones are an agricultural management strategy that can be used for decision‐making for controlling thrips on soybean fields. Thus, a 2‐year study was carried out on commercial soybean fields aimed at developing a decision‐making system for controlling soybean thrips using management zones. Three control programmes were established and assessed: Cl‐conventional control with insecticide use in the entire field; IPM‐CS‐conventional sampling plan + spray upon reaching the economic injury level (EIL; 3.43 thrips/sample); and IPM‐MZ‐spraying only specific areas of the field where thrips density reached the EIL. The decision to control reached using the IPM‐CS and IPM‐MZ programmes was 3× lower than those of the CI, which incurred in 75% mode decision mistakes. Furthermore, the decision to spray insecticides based on analysis of data for Cl was also incorrect. In 8.5% (3.6% of treated and 4.9% of non‐treated) of the field, the decisions of the IPM‐CS programme were incorrect. The total cost of the Cl programme (US$ 11.4/ha) was higher than that of the IPM‐CS and IPM‐MZ programmes (US$ 3.2 ha−1). Therefore, owing to its technical, economic, and environmental advantages, the establishment of management zones seems worthy of incorporation in integrated thrips management decision‐making systems for soybean fields.
Prognosis of pediatric ulcerative colitis after infliximab failure: A multicenter registry‐based cohort study
Authors: Nambu Ryusuke , Kudo Takahiro , Tachibana Nao , Shimizu Hirotaka , Mizuochi Tatsuki , Kato Sawako , Inoue Mikihiro , Kumagai Hideki , Ishige Takashi , Kunisaki Reiko , Noguchi Atsuko , Yodoshi Toshifumi , Hagiwara Shin‐Ichiro , Nishimata Shigeo , Kakuta Fumihiko , Saito Takeshi , Iwama Itaru , Hirano Yuri , Shimizu Toshiaki , Arai Katsuhiro ,   JPIBD‐R network
Published: December 2023

AbstractBackground and AimEven with increasing numbers of biologic agents available for management of ulcerative colitis (UC), infliximab (IFX) retains an important place in treatment of pediatric patients with this disease. As few reports have addressed outcomes in pediatric UC patients who had to discontinue IFX, we examined clinical course and prognosis after IFX failure in pediatric UC.MethodsA prospective cohort study of pertinent cases enrolled in the Japanese Pediatric Inflammatory Bowel Disease Registry between 2012 and 2020 was conducted to determine outcomes for pediatric UC patients who received IFX but required its discontinuation during follow‐up (IFX failure).ResultsOf the 301 pediatric UC patients in the registry, 75 were treated with IFX; in 36 of these, IFX was discontinued during follow‐up. Severity of UC at onset and absence of concomitant immunomodulator therapy were significant risk factors for IFX failure (P = 0.005 and P = 0.02, respectively). The cumulative colectomy rate after IFX failure was 41.3% at 1 year and 47.5% at 2 years. Colectomy was significantly more frequent when IFX was discontinued before June 1, 2018, than when IFX was discontinued later (P = 0.013). This difference likely involves availability of additional biologic agents for treatment of UC beginning in mid‐2018 (P = 0.005).ConclusionIn pediatric UC patients, approximately 50% underwent colectomy during a 2‐year interval following IFX failure. Prognosis after IFX failure appeared to improve with availability of new biologic agents and small‐molecule drugs in mid‐2018.
Christianity, Helping People in Poverty, and Embodied Relationships
Authors: Parsell Cameron , Stambe Rose 
Published: December 2023

AbstractThis article demonstrates that people animated by Christianity draw on faith to help people in poverty through building relationships. Contrasting with the literature that presents relationships as a means to change people, including through evangelizing, we find that relationships are conceived as an end in and of themselves. Drawing on an Australian ethnographic study with pastors and volunteers in church‐based community centers and people living in poverty, we illustrate how the realities of poverty subvert relationships. People in poverty prioritize their material needs. The challenges developing relationships notwithstanding, the article argues that elements of relationships found in this research represent an opportunity to advance knowledge of what it means to draw on faith to help people in poverty. Relationships can be a vehicle to change oppressive systems, but the capacity to do so must be assessed in the contexts of religion's position in dominant political and power structures.
Rhythmic histone acetylation acts in concert with day–night oscillation of the floral volatile metabolic network
Authors: Patrick Ryan M. , Huang Xing‐Qi , Dudareva Natalia , Li Ying 
Published: December 2023

Summary
The biosynthesis of specialized metabolites is strictly regulated by environmental inputs such as the day–night cycle, but the underlying mechanisms remain elusive. In Petunia hybrida cv. Mitchell flowers, the biosynthesis and emission of volatile compounds display a diurnal pattern with a peak in the evening to attract nocturnal pollinators.
Using petunia flowers as a model system, we found that chromatin level regulation, especially histone acetylation, plays an essential role in mediating the day–night oscillation of the biosynthetic gene network of specialized metabolites.
By performing time‐course chromatin immunoprecipitation assays for histone modifications, we uncovered that a specific group of genes involved in the regulation, biosynthesis, and emission of floral volatile compounds, which displays the greatest magnitude in day–night oscillating gene expression, is associated with highly dynamic histone acetylation marks H3K9ac and H3K27ac. Specifically, the strongest oscillating genes featured a drastic removal of histone acetylation marks at night, potentially to shut down the biosynthesis of floral volatile compounds during the morning when they are not needed. Inhibiting daytime histone acetylation led to a compromised evening induction of these genes.
Overall, our study suggested an active role of chromatin modification in the diurnal oscillation of specialized metabolic network.