bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic‐arm assisted total knee arthroplasty is associated with comparable functional outcomes but improved forgotten joint scores compared with conventional manual total knee arthroplasty at five‐year follow‐up
Authors: Kayani Babar , Fontalis Andreas , Haddad Isabella Catrina , Donovan Christian , Rajput Vishal , Haddad Fares Sami 
Published: October 2023

AbstractPurposeThis study reports the five‐year functional outcomes from a prospective cohort study comparing robotic‐arm assisted total knee arthroplasty (RO TKA) versus conventional manual total knee arthroplasty (CO TKA).MethodsThis prospective single‐surgeon study included 120 patients with symptomatic end‐stage knee arthritis undergoing primary TKA. This included 60 consecutive patients undergoing CO TKA followed by 60 consecutive patients undergoing RO TKA using a semi‐automated robotic device. Study patients were reviewed at one, two, and five years after surgery and the following outcomes recorded: The University of California at Los Angeles activity‐level (UCLA), Knee Society Score (KSS), Oxford Knee Score (OKS) Forgotten Joint Score (FJS), and any complications.ResultsThere were no statistical differences between RO TKA and CO TKA in the median UCLA score (p = N.S), median KSS (p = N.S), and median OKS (p = N.S) at five‐year follow‐up. RO‐TKA was associated with statistically significant improvements in the FJS at one (p = 0.001), two (p = 0.003), and five (p = 0.025) years of follow‐up compared with CO TKA. There was no statistical difference in the incidence of knee stiffness requiring manipulation under anesthesia between the two treatment groups (p = N.S).ConclusionPatients in both treatment groups had excellent functional outcomes with comparable patient reported outcomes at five‐year follow‐up. RO TKA was associated with statistically significant improvements in the FJS compared with CO TKA, but these differences did not reach the minimal clinically important difference at any follow‐up interval. There was no overall difference in complications between the two treatment groups at five‐year follow‐up.Level of evidenceII (Prospective cohort study).
The posterior cruciate ligament–posterior femoral cortex angle (PCL–PCA) and the lateral collateral ligament (LCL) sign are useful parameters to indicate the progression of knee decompensation over time after an ACL injury
Authors: Oronowicz Jakub , Mouton Caroline , Pioger Charles , Valcarenghi Jérôme , Tischer Thomas , Seil Romain 
Published: October 2023

AbstractPurposeThe posterior cruciate ligament–posterior cortex angle (angle between the most vertical part of the anterolateral PCL bundle and the posterior diaphyseal cortex of the femur; PCL–PCA) is the most accurate approach to describe the PCL buckling phenomenon observed in anterior cruciate ligament (ACL)‐deficient knees. The aim of this study was to determine whether the PCL–PCA is associated with chronicity of the ACL rupture, the meniscal status, preoperative knee laxity or imaging signs such as the lateral collateral ligament (LCL) sign or the posterior tibial slope (PTS) in ACL‐injured knees.MethodsPatients with a primary ACL reconstruction (ACLR) after physeal closure were selected retrospectively from a hospital‐based ACL registry from 2015 to 2021. Exclusion criteria were: previous ipsilateral/contralateral knee surgery, previous ipsilateral ACL or meniscal tear, ipsilateral PCL and/or collateral ligament injuries or tibial plateau fracture. The ACL deficiency was defined as chronic if time from injury to MRI was > 6 months. The meniscal status was assessed during ACLR, separately for the medial and lateral meniscus, and classified into no tear, minor or major unstable tear. The MRI analyses included the assessment of the PCL–PCA and the LCL sign. PTS was assessed from the lateral plain radiographs of the injured knee. The side‐to‐side difference in anterior tibial translation (ATT) at 200N was obtained with the GNRB.ResultsEighty‐two patients (forty‐eight males/thirty‐four females) were included in this study. The median PCL–PCA was 16.2° (Q1–Q3: 10.6–24.7) and differed between acute (18.4°) and chronic (10.7°) injuries (p < 0.01). The median PCL–PCA was significantly lower (− 4.6°) in patients with a positive LCL sign (p = 0.03) No significant association could be found between PCL–PCA and meniscal status, PTS or preoperative anterior knee laxity (Lachman, pivot shift and ATT in millimetres).ConclusionThe PCL–PCA was significantly lower in chronic ACL injuries and in patients with a positive LCL sign, indicating a higher buckling phenomenon of the PCL in these patients. These results support the fact that PCL–PCA and the LCL sign may be useful parameters to indicate the progression of knee decompensation over time after an ACL injury, and therefore may constitute a helpful tool to optimise treatment choice and timing of ACL reconstruction if necessary.Level of evidenceIII.
Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta‐analysis
Authors: Migliorini Filippo , Schäfer Luise , Bell Andreas , Weber Christian David , Vecchio Gianluca , Maffulli Nicola 
Published: October 2023

AbstractPurposeMeniscal tears are common and may impair knee function and biomechanics. This meta‐analysis compared meniscal repair versus resection in patients with symptomatic meniscal tears in terms of patient‐reported outcomes measures (PROMs), joint width, surgical failure, and rate of progression to osteoarthritis (OA) at conventional radiography.MethodsThis study was conducted according to the 2020 PRISMA statement. In August 2023, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. Two reviewers independently performed the analysis and a methodological quality assessment of the included studies. All the clinical investigations which compared repair versus resection of meniscal tears were accessed.ResultsData from 20 studies (31,783 patients) were collected. The mean BMI was 28.28 ± 3.2 kg/m2, and the mean age was 37.6 ± 14.0 years. The mean time elapsed from injury to surgery was 12.1 ± 10.2 months and the mean medial joint width was 4.9 ± 0.8 mm. Between studies comparability at baseline was found in age, women, BMI, time from injury to surgery and length of the follow‐up, PROMs, medial joint width, and stage of OA. The resection group demonstrated a greater Lysholm score (P = 0.02). No difference was found in the International Knee Documentation Committee (P = 0.2). Nine studies reported data on the rate of failures at a mean of 63.00 ± 24.7 months. No difference was found between the two groups in terms of persistent meniscal symptoms (P = 0.8). Six studies reported data on the rate of progression to total knee arthroplasty at a mean of 48.0 ± 14.7 months follow‐up. The repair group evidenced a lower rate of progression to knee arthroplasty (P = 0.0001). Six studies reported data on the rate of advanced knee OA at a mean of 48.0 ± 14.7 months of follow‐up. The repair group evidenced a lower rate of advanced knee OA (P = 0.0001). No difference was found in the mean joint space width (P = 0.09).ConclusionMeniscal repair is associated with a lower progression to knee osteoarthritis at approximately six years of follow‐up compared to partial meniscectomy. No difference in PROMs, medial joint width, and failures were evidenced.Level of evidenceLevel III, meta‐analysis.
The Yang–Mills–Higgs Functional on Complex Line Bundles: $$\Gamma $$-Convergence and the London Equation
Authors: Canevari Giacomo , Dipasquale Federico Luigi , Orlandi Giandomenico 
Published: October 2023

AbstractWe consider the Abelian Yang–Mills–Higgs functional, in the non-self dual scaling, on a complex line bundle over a closed Riemannian manifold of dimension $$n\ge 3$$

n
≥
3

. This functional is the natural generalisation of the Ginzburg–Landau model for superconductivity to the non-Euclidean setting. We prove a $$\Gamma $$
Γ
-convergence result, in the strongly repulsive limit, on the functional rescaled by the logarithm of the coupling parameter. As a corollary, we prove that the energy of minimisers concentrates on an area-minimising surface of dimension $$n-2$$

n
-
2

, while the curvature of minimisers converges to a solution of the London equation.
Ultraviolet photodissociation and collision-induced dissociation for qualitative/quantitative analysis of low molecular weight compounds by liquid chromatography-mass spectrometry
Authors: Giraud Romain , Le Blanc Yves J. C. , Guna Mircea , Hopfgartner Gérard 
Published: October 2023

AbstractCollision-induced dissociation (CID) is the most wildly used fragmentation technique for qualitative and quantitative determination of low molecular weight compounds (LMWC). Ultraviolet photodissociation (UVPD) has been mainly investigated for the analysis of peptides and lipids while only in a limited way for LMWC. A triple quadrupole linear ion trap instrument has been modified to allow ultraviolet photodissociation (UVPD) in the end of the q2 region enabling various workflows with and without data-dependent acquisition (DDA) combining CID and UVPD in the same LC–MS analysis. The performance of UVPD, with a 266-nm laser, is compared to CID for a mix of 90 molecules from different classes of LMWC including peptides, pesticides, pharmaceuticals, metabolites, and drugs of abuse. These two activation methods offer complementary fragments as well as common fragments with similar sensitivities for most analytes investigated. The versatility of UVPD and CID is also demonstrated for quantitative analysis in human plasma of bosentan and its desmethyl metabolite, used as model analytes. Different background signals are observed for both fragmentation methods as well as unique fragments which opens the possibility of developing a selective quantitative assay with improved sample throughput, in particular for analytes present in different matrices.
Graphical Abstract
Automated silylation of flavonoids using 3D printed microfluidics prior to chromatographic analysis: system development
Authors: Ncongwane Thabang Bernette , Ndinteh Derek Tantoh , Smit Elize 
Published: October 2023

AbstractFlavonoids are a class of secondary plant metabolites with low molecular weights. Most flavonoids are highly polar and unsuitable for gas chromatographic analyses. Derivatization is commonly used to make them amenable to gas chromatography by altering their physicochemical properties. Although highly effective, derivatization techniques introduce extra preparation steps and often use hazardous chemicals. The aim of this study was to automate derivatization (specifically, silylation) by developing 3D printed microfluidic devices in which derivatization of flavonoids can occur. A microfluidic device was designed and 3D printed using clear polypropylene. Quercetin and other flavonoids (TED 13 and ZTF 1016) isolated from plant extracts were silylated with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) at room temperature both in batch and in continuous flow. All the samples were analyzed using Fourier transform infrared (FTIR) spectroscopy, gas chromatography combined with mass spectrometry (GC–MS), and high-resolution accurate mass spectrometry (HR-MS). Interestingly, the HR-MS results showed that the flow method was about 25 times more efficient than the batch method for quercetin samples. The TED 13 flavonoid was completely derivatized in the flow method compared to the batch method where the reaction was incomplete. Similar results were observed for ZTF 1016, where the flow method resulted in a four times derivatized compound, while the compound was only derivatized once in batch. In conclusion, 3D printed microfluidic devices have been developed and used to demonstrate a semi-automated, inexpensive, and more efficient natural product derivatization method based on continuous flow chemistry as an alternative to the traditional batch method.
Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels
Authors: Lipinski Sarah , Lindekamp Niklas , Funck Nils , Cramer Benedikt , Humpf Hans-Ulrich 
Published: October 2023

AbstractFuran and alkylfurans are a group of contaminants formed through thermal processing. For breakfast cereals, this includes processing steps like extrusion cooking, roasting, puffing or baking. Furan was classified as possibly carcinogenic to humans (Group 2B) and, therefore, monitoring of this contaminant including other furans is of great interest. Breakfast cereals have been part of previous studies, but only few publications provided data regarding furan or alkylfuran levels in different groups of breakfast cereals. In this study, the furan and alkylfuran levels of over 70 samples have been analyzed and interpreted for 4 groups of breakfast cereals, namely flakes and cornflakes, extruded cereals, puffed grains and granolas. In this study, a solid phase microextraction method was established to extract the analytes from the headspace of the samples followed by gas chromatography–mass spectrometry analysis. In addition to furan, the alkylfurans 2-methylfuran, 3-methylfuran, 2,5-dimethylfuran, 2-ethylfuran and 2-pentylfuran were quantitated and levels up to 230 µg/kg furan and almost 200 µg/kg 2-pentylfuran were detected. The samples were also analyzed for acrylamide and in most cases no correlation with furan/alkylfurans was observed. Furthermore, during storage of the samples, the furan and methylfuran levels were stable but a rise of the levels of 2-ethylfuran and 2-pentylfuran was observed which is potentially linked to lipid oxidation.
Graphical Abstract
Effects of stochastic vestibular stimulation on cognitive performance in children with ADHD
Authors: Jostrup Erica , Nyström Marcus , Claesdotter-Knutsson Emma , Tallberg Pia , Gustafsson Peik , Paulander Oskar , Söderlund Göran 
Published: October 2023

AbstractPrevious work has shown that exposure to auditory white noise (WN) can improve cognitive performance in children with ADHD, but it is unknown whether this improvement generalizes to other sensory modalities. To address this knowledge gap, we tested the effect of Stochastic Vestibular Stimulation (SVS) on cognitive performance and reaction time (RT) variability in two groups: children with ADHD and typically developing children (TDC). Children with ADHD (N=42) and TDC (N=28) performed three cognitive tasks (Spanboard, Word Recall and N-back tasks) at two different occasions, with and without exposure to SVS, in a double blinded design. The results showed no main effects of SVS on neither performance nor RT variability for children in any of the groups, and no interactions between SVS and group. Based on these results we conclude that, using our stimulation protocol, the positive effects of WN exposure on cognition in children with ADHD do not generalize to Stochastic Vestibular Stimulation.
Feasibility and image quality of bright-blood and black-blood phase-sensitive inversion recovery (BOOST) sequence in clinical practice using for left atrial visualization in patients with atrial fibrillation
Authors: Dohy Zsófia , Kiss Máté , Suhai Ferenc Imre , Kunze Karl , Neji Radhouene , Orbán Gábor , Drobni Zsófia , Czimbalmos Csilla , Juhász Vencel , Szabó Liliána , Botnar Rene , Prieto Claudia , Merkely Béla , Szegedi Nándor , Vágó Hajnalka 
Published: October 2023

Abstract
Objectives
Visualizing left atrial anatomy including the pulmonary veins (PVs) is important for planning the procedure of pulmonary vein isolation with ablation in patients with atrial fibrillation (AF). The aims of our study are to investigate the feasibility of the 3D whole-heart bright-blood and black-blood phase-sensitive (BOOST) inversion recovery sequence in patients with AF scheduled for ablation or electro-cardioversion, and to analyze the correlation between image quality and heart rate and rhythm of patients.

Methods
BOOST was performed for assessing PVs both with T2 preparation pre-pulse (T2prep) and magnetization transfer preparation (MTC) in 45 patients with paroxysmal or permanent AF scheduled for ablation or electro-cardioversion. Image quality analyses were performed by two independent observers. Qualitative assessment was made using the Likert scale; for quantitative analysis, signal to noise ratios (SNR) and contrast to noise ratios (CNR) were calculated for each PV. Heart rate and rhythm were analyzed based on standard 12-lead ECGs.

Results
All MTC-BOOST acquisitions achieved diagnostic quality in the PVs, while a significant proportion of T2prep-BOOST images were not suitable for assessing PVs. SNR and CNR values of the MTC-BOOST bright-blood images were higher if patients had sinus rhythm. We found a significant or nearly significant negative correlation between heart rate and the SNR and CNR values of MTC-BOOST bright-blood images.

Conclusion
3D whole-heart MTC-BOOST bright-blood imaging is suitable for visualizing the PVs in patients with AF, producing diagnostic image quality in 100% of cases. However, image quality was influenced by heart rate and rhythm.

Clinical relevance statement
The novel 3D whole-heart BOOST CMR sequence needs no contrast administration and is performed during free-breathing; therefore, it is easy to use for a wide range of patients and is suitable for visualizing the PVs in patients with AF.

Key Points
• The applicability of the novel 3D whole-heart bright-blood and black-blood phase-sensitive sequence to pulmonary vein imaging in clinical practice is unknown.
• Magnetization transfer-bright-blood and black-blood phase-sensitive imaging is suitable for visualizing the pulmonary veins in patients with atrial fibrillation with excellent or good image quality.
• Bright-blood and black-blood phase-sensitive cardiac magnetic resonance sequence is easy to use for a wide range of patients as it needs no contrast administration and is performed during free-breathing.
Global facial soft tissue thicknesses for craniofacial identification (2023): a review of 140 years of data since Welcker’s first study
Authors: Hona Te Wai Pounamu T. , Stephan Carl N. 
Published: October 2023

AbstractThis year (2023) marks 140 years since the first publication of a facial soft tissue thickness (FSTT) study. Since 1883, a total of 139 studies have been published, collectively tallying > 220,000 tissue thickness measurements of > 19,500 adults. In just the last 5-years, 33 FSTT studies have been conducted. Herein, we add these data (plus an additional 20 studies) to the 2018 T-Table to provide an update of > 81,000 new datapoints to the global tallied facial soft tissue depths table. In contrast to the original 2008 T-Table, some notable changes are as follows: increased FSTTs by 3 mm at infra second molar (ecm2–iM2ʹ), 2.5 mm at gonion (go–goʹ), 2 mm at mid-ramus (mr–mrʹ), and 1.5 mm at zygion (zy–zyʹ). Rolling grand means indicate that stable values have been attained for all nine median FSTT landmarks, while six out of nine bilateral landmarks continue to show ongoing fluctuations, indicating further data collection at these landmarks holds value. When used as point estimators for individuals with known values across 24 landmarks (i.e., C-Table data), the updated grand means produce slightly less estimation error than the 2018 T-Table means (3.5 mm versus 3.6 mm, respectively). Future efforts to produce less noisy datasets (i.e., reduce measurement and sampling errors as much as possible between studies) would be useful.
Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad
Authors: Sibbach Brandon M. , Karim Helmet T. , Lo Daniel , Kasibhatla Nithya , Santini Tales , Weber Jessica C. , Ibrahim Tamer S. , Banihashemi Layla 
Published: October 2023

AbstractThe paraventricular nucleus of the hypothalamus (PVN) is uniquely capable of proximal control over autonomic and neuroendocrine stress responses, and the bed nucleus of the stria terminalis (BNST) directly modulates PVN function, as well as playing an important role in stress control itself. The dorsal BNST (dBNST) is predominantly preautonomic, while the ventral BNST (vBNST) is predominantly viscerosensory, receiving dense noradrenergic signaling. Distinguishing the dBNST and vBNST, along with the PVN, may facilitate our understanding of dynamic interactions among these regions. T1-weighted MPRAGE and high resolution gradient echo (GRE) modalities were acquired at 7T. GRE was coregistered to MPRAGE and segmentations were performed in MRIcroGL based on their Atlas of the Human Brain depictions. The dBNST, vBNST and PVN were manually segmented in 25 participants; 10 images were rated by 2 raters. These segmentations were normalized and probabilistic atlases for each region were generated in MNI space, now available as resources for future research. We found moderate–high inter-rater reliability [n = 10; Mean Dice (SD); PVN = 0.69 (0.04); dBNST = 0.77 (0.04); vBNST = 0.62 (0.04)]. Probabilistic atlases were reverse normalized into native space for six additional participants that were segmented but not included in the original 25. We also found moderate to moderate–high reliability between the probabilistic atlases and manual segmentations [n = 6; Mean Dice (SD); PVN = 0.55 (0.12); dBNST = 0.60 (0.10); vBNST = 0.47 (0.12 SD)]. By isolating these hypothalamic and BNST subregions using ultra-high field MRI modalities, more specific delineations of these regions can facilitate greater understanding of mechanisms underlying stress-related function and psychopathology.
Infant liver biochemistry is different than current laboratory accepted norms
Authors: Kolho Kaija-Leena , Lahtiharju Tapio , Merras-Salmio Laura , Pakarinen Mikko P. , Knip Mikael 
Published: October 2023

AbstractThe purpose is to study liver biochemistry in a well-defined cohort of term infants. The methods include healthy term infants (n = 619) provided blood samples at 3 and 6 months of age when participating to the DIABIMMUNE study. The infants were followed up at clinical study visits 3, 6, 12, 18, 24, and 36 months the participation rate being 88.6% at the end of follow-up, while none disclosed any signs of a liver disease. The serum levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (BIL), and conjugated bilirubin (BIL-conj) were determined using Siemens Atellica CH 930 analyzers. The results are at 3 months of age, the upper 90% CI for ALT, AST, ALP, GGT, BIL, and BIL-conj were higher than the current upper reference limits in our accredited hospital laboratory. At 6 months, the upper 90% CIs for ALT had declined but was still higher than the cut-offs for a raised value. The upper 90% CI for AST remained as high as at 3 months, whereas ALP, BIL-conj, and GGT had decreased close to the current cut-offs. The type of feeding was associated with the levels of liver biochemistry. Exclusively or partially breastfed infants showed higher ALT, AST, BIL, and BIL-conj values at 3 months than formula-fed. Breastfed infants had higher AST, Bil, and Bil-conj values also at 6 months. Conclusion: We encourage setting appropriate reference ranges for liver biochemistry for the first year of life and to note the type of feeding.

What is Known:• Healthy infants may show higher values of liver biochemistry during their first year of life than in later life.• It has been speculated that type of feeding may play a role in liver biochemistry levels among infants.

What is New:• In a cohort of healthy infants, several analytes of liver biochemistry were higher than the currently used upper reference limits at 3 and 6 months of age, and exclusively or partially breastfed infants showed higher values than formula-fed.• The findings address the importance of setting appropriate reference ranges for liver biochemistry for the first year of life.