bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Learning Dacilities and Learning Discipline for the Result Grade VII SMP Negeri 7 Pematang Siantar
Authors: Ivan Rivaldo Purba  , Anton Luvi Siahaan  , Sotarduga Sihombing  
Published: December 2023

This research aims to find out how learning facilities and discipline influence the learning outcomes of class VII students at SMP Negeri 7 Pematang Siantar. The variables in this research are learning facilities and discipline as independent variables and learning outcomes as dependent variables. This type of research is quantitative descriptive research, with a population of all class VII students at SMP Negeri 7 Pematang Siantar totaling 222 . students and the research sample was 145 students selected using random sampling techniques . Data collection techniques use observation and questionnaires, while data analysis techniques use validity tests, reliability tests, normality tests, multicollinearity tests, heteroscedasticity, multiple linear regression, t tests, f tests, and coefficient of determination tests (R2).
​The results of this research indicate that there is no positive and significant influence between learning facilities on the learning outcomes of class VII students at SMP Negeri 7 Pematang Siantar as seen from the tcountl<ttable or 1.032<1.6556. There is a positive and significant influence between learning discipline on the learning outcomes of class VII students at SMP Negeri 7 Pematang Siantar as seen from the value of tcount>ttable or 3.338> 1.6556 . There is a positive and significant influence between learning facilities and discipline on the learning outcomes of class VII students at SMP Negeri 7 Pematang Siantar as seen from the fcount>ftable value or 6.416>3.06 and the significant value is 0.001<0.05.
The Review of Household Agri-product Processing in Cambodia
Authors: Broem Koeun  , Serey Mardy  
Published: December 2023

In Cambodia, domestic processing accounts for about 10% of total agricultural output, while processed agricultural exports make up only 8% of all official exports by value. Processing and handling of agricultural products after harvest need private investment if Cambodia is to benefit economically from adding value to its produce. There aren't many big businesses involved in agro-processing. Among the possible activities include the processing of dairy products, cashew nuts, sugar, fruits, fish products, meat, and cassava. Publicly available studies on Cambodian household agriproduct processing are also included in this review. An article based on literature research is this study. Food processing includes postharvest processing methods as well as packhouse, transport, market, and processing. The key to handling the issue of processing these productions is agro-processing. Items like candy, pickles, sausages, meatballs, fish balls, Prahok, frozen dairy, and soy milk, among others. The majority of agriculturally processed products are exported informally since they lack branding, packaging, certification, or licencing. However, implementing agro-processing in Cambodia is fraught with difficulties involving labour, knowledge, machinery, equipment, and exporters' maintenance of the machinery.
Dialect Variations the Enrichment of Standard Igbo Language: A Linguistic Study
Authors: Dom-Anyanwu  , Benjamin F.C Nwokedi  , Eneremadu Queen Esther Chioma  
Published: December 2023

Historically, many languages of the world evolved their standard forms through centralized control or political unity. Considering the decentralized natured of the Igbo unity, the dream evolving a standard form through much means, remains a mirage and unrealistic. Therefore, Igbo scholars are forced with the task of achieved this goal, we must used what we have to get what we want. In other words, we cannot enrich the evolving standard Igbo by using the dialectal variants in the language. Igbo dialectal variation and the dialect variants as synonyms, with comparative study of five dialects: Owerri, oguuta, Afikpo, Nnewi and Ngwa (ibeme) at the phonological, morphological and syntactic levels. The paper discuss the standard Igbo vis-a- vis dialects and meta-language as the tool for its enrichment which consist of the effect of dialectal variation, including the conclusion and recommendations made that rather than being a conclusive linguistic study on dialectal variation for the enrichment of standard Igbo, would serve as a stimulus for further intensive researches.
Proximate, Phytochemical Analysis and Pharmacological Profile of Cassia Torra Native to Zuru Town, Kebbi State Nigeria
Authors: Garba Aliyu , Usman Rufai  Fakai  
Published: December 2023

Cassia tora, is commonly found in Nigeria, it’s annual shrub which grows in a wild land. The plant and its different parts are used for their nutritional and medicinal purposes. In the present study, an attempt was made to investigate nutritional contents, phytochemical analysis and medicainal evaluation of Cassia tora. The crude powder extracts of the leaves of the plants were taken for the study. The phytochemical Screening was done for the selected plants. Phytochemistry of the plant reveals that Cassia tora contains anthraquinones, protein, carbohydrates, saponins, glycosides, fixed oils and fats. Several chemical contents such asnaphthopyrone glycosides, flavonoids, glycosides, anthraquinone, etc. have beenseparated from this plant. The plants has been found to have hepatoprotective, antigenotoxic, antipsoriatic, antinociceptive, immunostimulatory, anticancerous, antifeedant, larvicidal, antiproliferative, hypolipidemic, antimutagenic activity. It also has a property of mild laxative and diuretics so can be used in constipation, dyspepsia and flatulence. Its decoction is used for healing and washing of wounds.
Innovación TIC en los Planes de Estudio de las Menciones de Música en los Grados de Educación en España
Authors: Montoya Rubio Juan Carlos , López Núñez Norberto , López Núñez Alba María 
Published: December 2023

This research proposes an approach to the curricula of the degrees of education, in order to verify the level of use of technological resources (both information technology and audiovisual techniques) in the mentions related to music education to determine, on the one hand, if it is appropriate and, on the other hand, to what extent its empowerment can lead to global benefits for music pedagogy. The methodology used combines a quantitative study, analysing the mention subjects of 39 Spanish public universities teaching programmes, with an interpretative approach, trying to postulate, according to the literature on ICT in music, a model of change that guides university practices towards comprehensive education through teaching innovation. Understanding the difficulty of optimizing the low academic load resulting from the process of adapting the old degrees to new ones, the results point the deficit in the use of technology in the major subjects of most Spanish universities. In this sense, the possibility of enhancing the virtues of music teaching in its connection with students through technological resources is discussed, in order to project this type of knowledge towards a society like the current one, which requires a treatment closer to non-formal musical practices.
Esta investigación plantea una aproximación a los planes de estudio de los grados en educación para constatar el nivel de uso de los recursos tecnológicos (tanto informáticos como audiovisuales) en las menciones vinculadas a la educación musical, con el fin de determinar, por un lado, si es adecuado y, por otro, hasta qué punto su potenciación puede revertir en beneficios globales para la pedagogía musical. La metodología utilizada combina un estudio cuantitativo, analizando los planes de estudios de las asignaturas de mención vinculadas a la música de 39 universidades públicas españolas, con un enfoque descriptivo e interpretativo, ya que se recogen datos cuantitativos que se pretenden interpretar, no solo describir, sirviendo como un modelo de cambio que oriente las prácticas universitarias hacia la educación integral a través de la innovación docente. Conscientes de la dificultad de optimizar la escasa carga lectiva resultante del proceso de adaptación de las antiguas diplomaturas a los actuales grados, los resultados observados apuntan al déficit en cuanto al uso de las tecnologías en las asignaturas de mención de la mayoría de las universidades españolas. En este sentido, se discute la posibilidad de potenciar las virtudes de la enseñanza de la música en su conexión con el alumnado a través de recursos tecnológicos, con el fin de proyectar este tipo de conocimientos hacia una sociedad como la actual, la cual requiere un trato más cercano a prácticas musicales no formales.
ANALISIS KECELAKAAN LALU LINTAS PADA RUAS JALAN KINALI-SIMPANG EMPAT PASAMAN BARAT
Authors: Daniati Sisra , Kurniawan Deddy , Bastian Elfani 
Published: December 2023

The Kinali-Simpang Empat road in Kabupaten Pasaman Barat has a fairly high accident rate with a length 23 Km and an effective width of 7 m. This analysis is used to determine the characteristic of accidents and the factors that cause traffic accident. The method used in this analysis is the AEK (Accident Equivalent Rate) method and the correlation test using SPSS. Based on the results of the analysis, there is the highest number of each characteristic namely based on the type of victim as many as 91 victims with minor injuries category, based on the day 41 cases that occurred on Sunday, based on the time of the incident 141 cases of accidents that occurred at 06.00 – 19.00, based on the type of vehicle involved 169 cases with the type of motorcycle vehicle, based on the age of the suspect and victim 83 cases with an age range of 16-30 years, based on the type of accident what happened 71 cases with front-to-front collision type accident, based on the location of the accident 59 cases with locations in Rimbo Tampoeroeng, and for the main factor causing the accident 104 cases with the drive category. Efforts to prevent traffic accident are to provide traffic education and strict sanctions on road user who violate traffic regulations.
Racial and Ethnic Differences in Hospice Use Among Medicaid-Only and Dual-Eligible Decedents
Authors: Robison Julie , Shugrue Noreen , Dillon Ellis , Migneault Deborah , Charles Doreek , Wakefield Dorothy , Richards Bradley 
Published: December 2023

ImportanceHospice care enhances quality of life for people with terminal illness and is most beneficial with longer length of stay (LOS). Most hospice research focuses on the Medicare-insured population. Little is known about hospice use for the racially and ethnically diverse, low-income Medicaid population.ObjectiveTo compare hospice use and hospice LOS by race and ethnicity among Medicaid-only individuals and those with dual eligibility for Medicare and Medicaid (duals) in the Connecticut Medicaid program who died over a 4-year period.Design, Setting, and ParticipantsThis retrospective population-based cohort study used Medicaid and traditional Medicare enrollment and claims data for 2015 to 2020. The study included Connecticut Medicaid recipients with at least 1 of 5 most common hospice diagnoses who died from 2017 to 2020.ExposureRace and ethnicity.Main Outcomes and MeasuresHospice use (yes/no) and hospice LOS (1-7 days vs ≥8 days.) Covariates included sex, age, and nursing facility stay within 60 days of death.ResultsOverall, 2407 Medicaid only and 23 857 duals were included. Medicaid-only decedents were younger (13.8% ≥85 vs 52.5%), more likely to be male (50.6% vs 36.4%), more racially and ethnically diverse (48.7% non-Hispanic White vs 79.9%), and less likely to have a nursing facility stay (34.9% vs 56.1%). Race and ethnicity were significantly associated with hospice use and LOS in both populations: non-Hispanic Black and Hispanic decedents had lower odds of using hospice than non-Hispanic White decedents, and Hispanic decedents had higher odds of a short LOS. In both populations, older age and female sex were also associated with more hospice use. For duals only, higher age was associated with lower odds of short LOS. For decedents with nursing facility stays, compared with those without, Medicaid-only decedents had higher odds of using hospice (odds ratio [OR], 1.49; 95% CI, 1.24-1.78); duals had lower odds (OR, 0.60; 95% CI, 0.57-0.63). Compared with decedents without nursing facility stays, duals with a nursing facility stay had higher odds of short LOS (OR, 2.63; 95% CI, 2.43-2.85).Conclusions and RelevanceFindings raise concerns about equity and timing of access to hospice for Hispanic and non-Hispanic Black individuals in these understudied Medicaid populations. Knowledge about, access to, and acceptance of hospice may be lacking for these low-income individuals. Further research is needed to understand barriers to and facilitators of hospice use for people with nursing facility stays.
Subcutaneous batoclimab in generalized myasthenia gravis: Results from a Phase 2a trial with an open‐label extension
Authors: Nowak Richard J. , Breiner Ari , Bril Vera , Allen Jeffrey A. , Khan Shaida , Levine Todd , Jacobs Daniel H. , Sahagian Gregory , Siddiqi Zaeem A. , Xu Jing , Macias William L. , Benatar Michael ,   ASCEND MG Study Group
Published: December 2023

AbstractObjectivesTo assess the safety, tolerability, and key pharmacodynamic effects of subcutaneous batoclimab, a fully human anti‐neonatal Fc receptor monoclonal antibody, in patients with generalized myasthenia gravis and anti‐acetylcholine receptor antibodies.MethodsA Phase 2a, proof‐of‐concept, randomized, double‐blind, placebo‐controlled trial is described. Eligible patients were randomized (1:1:1) to receive once‐weekly subcutaneous injections of batoclimab 340 mg, batoclimab 680 mg, or matching placebo for 6 weeks. Subsequently, all patients could enter an open‐label extension study where they received batoclimab 340 mg once every 2 weeks for 6 weeks. Primary endpoints were safety, tolerability, and change from baseline in total immunoglobulin G, immunoglobulin G subclasses, and anti‐acetylcholine receptor antibodies at 6 weeks post‐baseline. Secondary endpoints included changes from baseline to 6 weeks post‐baseline for Myasthenia Gravis Activities of Daily Living, Quantitative Myasthenia Gravis, Myasthenia Gravis Composite, and revised 15‐item Myasthenia Gravis Quality of Life scores.ResultsSeventeen patients were randomized to batoclimab 680 mg (n = 6), batoclimab 340 mg (n = 5), or placebo (n = 6). Batoclimab was associated with significantly greater reductions in total immunoglobulin G and anti‐acetylcholine receptor antibodies from baseline to 6 weeks post‐baseline than placebo. Reductions in immunoglobulin G subclasses were generally consistent with total immunoglobulin G. While clinical measures showed directionally favorable improvements over time, the study was not powered to draw conclusions about therapeutic efficacy. No safety issues were identified.InterpretationThe safety profile, pharmacodynamics, and preliminary clinical benefits observed in this study support further investigation of subcutaneous batoclimab injections as a potential patient‐administered therapy for seropositive generalized myasthenia gravis.
Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1
Authors: Ding Yao , Cen Zhidong , Zheng Yang , Qiu Xia , Ye Yumao , Chen Xinhui , Hu Lingli , Wang Bo , Wang Zhongjin , Yin Houmin , Shen Chunhong , Ming Wenjie , Ge Yi , Xie Fei , Yang Dehao , Ouyang Zhiyuan , Wang Haotian , Wu Sheng , Ding Meiping , Wang Shuang , Luo Wei 
Published: December 2023

AbstractObjectivesTo investigate and characterize epileptic seizures and electrophysiological features of familial cortical myoclonic tremor with epilepsy (FCMTE) type 1 patients in a large Chinese cohort.MethodsWe systematically evaluated 125 FCMTEtype 1 patients carrying the pentanucleotide (TTTCA) repeat expansion in the SAMD12 gene in China.ResultsAmong the 28 probands, epileptic seizures (96.4%, 27/28) were the most common reason for an initial clinic visit. Ninety‐seven (77.6%, 97/125) patients had experienced seizures. The seizures onset age was 36.5 ± 9.0 years, which was 6.9 years later than cortical tremors. The seizures were largely rare (<1/year, 58.8%) and occasional (1–6/year, 37.1%). Prolonged prodromes were reported in 57.7% (56/97). Thirty‐one patients (24.8%, 31/125) reported photosensitivity history, and 79.5% (31/39) had a photoparoxysmal response. Interictal epileptiform discharges (IEDs) were recorded in 69.1% (56/81) of patients. Thirty‐three patients showed generalized IEDs and 72.7% (24/33) were occipitally dominant, while 23 patients presented with focal IEDs with 65.2% (15/23) taking place over the occipital lobe. Overnight EEG of FCMTE patients displayed paradoxical sleep–wake fluctuation, with a higher average IED index of 0.82 ± 0.88/min during wakefulness and a lower IED index of 0.04 ± 0.06/min during non‐rapid eye movement sleep stages I–II.InterpretationFCMTE type 1 has a benign course of epilepsy and distinct clinical and electrophysiological features. In addition to a positive family history and cortical myoclonus tremor, the seizure prodromes, specific seizure triggers, photosensitivity, distribution of IEDs, and unique fluctuations during sleep–wake cycle are cues for proper genetic testing and an early diagnosis of FCMTE.
A Novel Approach to Increase Glial Cell Populations in Brain Microphysiological Systems
Authors: Morales Pantoja Itzy E. , Ding Lixuan , Leite Paulo E. C. , Marques Suelen A. , Romero July Carolina , Alam El Din Dowlette‐Mary , Zack Donald J. , Chamling Xitiz , Smirnova Lena 
Published: December 2023

AbstractBrain microphysiological systems (bMPS) recapitulate human brain cellular architecture and functionality more closely than traditional monolayer cultures and have become increasingly relevant for the study of neurological function in health and disease. Existing 3D brain models vary in reflecting the relative populations of different cell types present in the human brain. Most models consist mainly of neurons, while glial cells represent a smaller portion of the cell populations. Here, by means of a chemically defined glial‐enriched medium (GEM), an improved method to expand the population of astrocytes and oligodendrocytes without compromising neuronal differentiation in bMPS, is presented. An important finding is that astrocytes also change in morphology when cultured in GEM, more closely recapitulating primary culture astrocytes. GEM bMPS are electro‐chemically active and show different patterns of calcium staining and flux. Synaptic vesicles and terminals observed by electron microscopy are also present. No significant changes in neuronal differentiation are observed by gene expression, however, GEM enhanced neurite outgrowth and cell migration, and differentially modulated neuronal maturation in two different cell lines. These results have the potential to significantly improve functionality of bMPS for the study of neurological diseases and drug discovery, contributing to the unmet need for safe human models.
Treatment with Cerebrolysin Prolongs Lifespan in a Mouse Model of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Authors: Kastberger Birgit , Winter Stefan , Brandstätter Hemma , Biller Janina , Wagner Wolfgang , Plesnila Nikolaus 
Published: December 2023

AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare familial neurological disorder caused by mutations in the NOTCH3 gene and characterized by migraine attacks, depressive episodes, lacunar strokes, dementia, and premature death. Since there is no therapy for CADASIL the authors investigate whether the multi‐modal neuropeptide drug Cerebrolysin may improve outcome in a murine CADASIL model. Twelve‐month‐old NOTCH3R169C mutant mice (n=176) are treated for nine weeks with Cerebrolysin or Vehicle and histopathological and functional outcomes are evaluated within the subsequent ten months. Cerebrolysin treatment improves spatial memory and overall health, reduces epigenetic aging, and prolongs lifespan, however, CADASIL‐specific white matter vacuolization is not affected. On the molecular level Cerebrolysin treatment increases expression of Calcitonin Gene‐Related Peptide (CGRP) and Silent Information Regulator Two (Sir2)‐like protein 6 (SIRT6), decreases expression of Insulin‐like Growth Factor 1 (IGF‐1), and normalizes the expression of neurovascular laminin. In summary, Cerebrolysin fosters longevity and healthy aging without specifically affecting CADASIL pathology. Hence, Cerebrolysin may serve a therapeutic option for CADASIL and other disorders characterized by accelerated aging.
Biomimetic Chiral Nanotopography for Manipulating Immunological Response
Authors: He Yide , Zhang Xige , Meng Fanhui , Wang Jinjin , Li Yi , Zhang Yan , Song Wen , Li Tianjie , Zhang Yumei 
Published: December 2023

AbstractImmune response regulates implanted biomaterial−tissue integration and tissue regeneration, in which macrophages play a key role due to their plasticity and polarization. Chirality, an inherent property of carbon‐based life, can also exist in biomaterials such as gold monolayer. Constructing chiral nanostructured surfaces of implants can imitate the chirality of extracellular environment in a biomimetic manner, but the manipulation and mechanism of chiral nanotopography on macrophages remain poorly understood. Here, highly ordered gold nanoparticle arrays with 300 or 900 nm spacing are fabricated and modified with L‐ or D‐chirality. The D‐nanoarrays can promote M2 polarization and related cytokine secretion of macrophages, thus facilitating the reduction of inflammatory reaction and promoting tissue healing and regeneration. The mechanistic analysis further suggests that D‐nanoarrays proceeded these regulations through enhancing the expression of integrin αv/α8/β3‐p‐FAK pathway in macrophages, which may be largely attributed to its higher stereo‐affinity for fibronectin as revealed by quantitative experiments and molecular dynamics simulations. Overall, this study demonstrates that biomimetic chiral nanotopography can promote biomaterial−tissue integration by manipulating macrophage phenotype, bringing a novel strategy for immunomodulation.
Cotton Fibers with a Lactic Acid‐Like Surface for Re‐establishment of Protective Lactobacillus Microbiota by Selectively Inhibiting Vaginal Pathogens
Authors: Wu Yuzheng , Liu Pei , Liao Qing , Jin Tao , Wu Zhengwei , Wang Guomin , Wang Huaiyu , Chu Paul K. 
Published: December 2023

AbstractFailure to reconstruct the Lactobacillus microbiota is the major reason for the recurrence of vaginal infection. However, most empiric therapies focus on the efficacy of pathogen elimination but do not sufficiently consider the viability of Lactobacillus. Herein, cotton fibers with a lactic acid‐like surface (LC) are fabricated by NaIO4 oxidation and L‐isoserine grafting. The lactic acid analog chain ends and imine structure of LC can penetrate cell walls to cause protein cleavage in Escherichia coli and Candida albicans and inhibit vaginal pathogens. Meanwhile, the viability of Lactobacillus acidophilus is unaffected by the LC treatment, thus revealing a selective way to suppress pathogens as well as provide a positive route to re‐establish protective microbiota in the vaginal tract. Moreover, LC has excellent properties such as good biosafety, antiadhesion, water absorption, and weight retention. The strategy proposed here not only is practical, but also provides insights into the treatment of vaginal infections.