bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lady Jane Lumley’s Private Education and Its Political Resonances
Authors: da Silva Perez Natália 
Published: December 2023

AbstractIn this chapter, Natália da Silva Perez focuses on Lady Jane Lumley, who lived in England in the middle of the sixteenth century. As a young member of a noble household close to the throne, her study practices were fomented and shaped by her family’s political aspirations and alignments, all the while remaining within the private circle of her family. In what follows, Silva Perez maps ideas that Lady Lumley articulated through translations and letters that she wrote for her father as a young woman. In her texts, the private, the political, and the public appear not as distinct categories but are rather co-constructed as mutually interdependent.
“Fait à mes heures de loisir”: Women’s Private Libraries as Spaces of Learning and Knowledge Production
Authors: Weis Joëlle 
Published: December 2023

AbstractThe Duchesses Elisabeth Sophie Marie (1683–1767) and Philippine Charlotte of Brunswick- Wolfenbüttel (1716–1801) both owned substantial collections of several thousand books. Elisabeth’s library primarily contained theological literature, including 1200 Bibles and a unique collection of texts by Martin Luther, which she used to compose theological pamphlets. In addition, she granted access to her collection to selected scholars who, in turn, used the holdings for their research. Although more diversified, Philippine Charlotte’s library functioned as a similar meeting place for scholars of the region and beyond. Moreover, her papers offer an insight into the interaction between her book use and the writing that she did in her free time. In contrast to the usage practices of the neighbouring ducal library, Philippine Charlotte was free to consult the books she wanted in the privacy of her chambers for as long as she wanted to and, most importantly, without fear of being judged. It is certain that, in both cases, the privacy of the library gave the women the freedom to pursue intellectual interests, which were hard to combine with their public role as Duchesses. The fact that both women expanded their libraries considerably after becoming widows only supports the observation that private and “leisure” time could take more space. Based on these findings, this chapter argues that women’s learning and knowledge production in the early modern period both benefitted from and, in many cases, needed privacy.
Youth Homelessness in the Danish Welfare State: How Do Young Persons in Homelessness Mobilise Rights?
Authors: Nielsen Stine Piilgaard Porner , Hammerslev Ole 
Published: December 2023

AbstractThis chapter offers a bottom-up perspective on welfare rights in practice, analysing legal mobilisation by young persons in homelessness in the Danish welfare state. Youth homelessness is selected as case motivated by the fact that the number of persons aged 18 to 29 living in homelessness almost doubled from 2009 to 2019. Drawing on the young persons’ narratives, the chapter stresses that their rights consciousness, social network and sense of welfare bureaucracy are decisive for their ability to mobilise welfare rights. Without these factors, the young persons may find themselves lost in a complex welfare state system, leaving them in increasingly marginalised situations. Based on the chapter’s analyses, a distinction is made between active and passive agency to illustrate the dynamic character of legal mobilisation processes.
Einführung in das Themenfeld
Authors: Meller Stefan 
Published: December 2023

ZusammenfassungBereits zu Beginn der 2010er-Jahre konnte eine verstärkte Nutzung von Onlinevideos für persönliche Lernzwecke beobachtet werden. Nicht zuletzt die Coronapandemie und die damit verbundenen Schulschließungen – mit der Notwendigkeit, Fernunterrichtsangebote zu schaffen – haben seit 2020 dazu geführt, dass sich der Einsatz audiovisueller Medien auch für Lehr- und Lernprozesse im Schulsystem endgültig durchgesetzt hat. Doch schon vor der Coronapandemie etablierte sich das audiovisuelle Format des Erklärvideos zu einem beliebten Medium „in Bereichen des informellen und formellen Lernens […], um Inhalte zu veranschaulichen und den Erwerb von Fertigkeiten und Wissen zu unterstützen“ und „neues Wissen und Informationen zielgruppenspezifisch zu präsentieren und […] einer Vielzahl von Menschen zugänglich zu machen“.
Theoretische Grundlagen
Authors: Meller Stefan 
Published: December 2023

ZusammenfassungDie Ursprünge des Sachunterrichts reichen zurück bis zum Realien- und Anschauungsunterricht des 17. Jahrhunderts. Johann Amos Comenius (1698) verfasste in dieser Zeit sein bedeutendes Werk „Orbis sensualium pictus“ („Die Welt im Bild“), ein Schul- bzw. Sachbuch, dessen Besonderheit darin bestand, jeden Lerninhalt auch mithilfe einer Zeichnung zu illustrieren und damit – im wahrsten Sinne des Wortes – zu veranschaulichen. In Comenius’ Werken „wird der Begriff ‚Sachunterricht‘ z. B. in Abgrenzung zum Sprachunterricht explizit erwähnt, wobei sich der Sachunterricht mit den Realien befasst“.
Zusammenschau und Diskussion
Authors: Meller Stefan 
Published: December 2023

ZusammenfassungDie in Kapitel 3 beschriebene explorative Studie verfolgte das Ziel, aus den subjektiven Sichtweisen von Sachunterrichtslehrkräften ein breites Spektrum an Erkenntnissen zum Einsatz von Erklärvideos im Sachunterricht abzubilden. Die qualitativ-empirische Untersuchung im Sinne der Grounded-Theory-Methodologie erfasste in drei Forschungszyklen über fokussierte Interviews die Aussagen von insgesamt 24 Volks- und Grundschullehrkräften zum audiovisuellen Medium im Kontext des Unterrichtsfachs Sachunterricht. Der iterative Charakter des Forschungsprozesses erlaubte es, neu gewonnene Erkenntnisse unmittelbar im Untersuchungsfeld anhand weiterführender Interviews zu überprüfen und damit schrittweise ein vertiefendes Verständnis der Rahmenbedingungen des Erklärvideoeinsatzes im Sachunterricht aus Sicht der Lehrkräfte zu erlangen.
Organoide in der Zelltherapie
Authors: Bartfeld Sina 
Published: December 2023

ZusammenfassungOrganoide sind aus Stammzellen entstehende, dreidimensionale zelluläre Gebilde, in denen sich Stammzellen, Vorläuferzellen und differenzierte Zellen selbst organisieren. Organoide werden erfolgreich in der Grundlagenforschung eingesetzt; eine breite Anwendung in der Medikamentenentwicklung, in Toxizitätsstudien und in der personalisierten Medizin zeichnet sich ab. Der Einsatz von Organoiden als Transplantationsmaterial ist im Vergleich dazu noch in den Anfängen. Einzelne Transplantationen werden jedoch an menschlichen Organen ex vivo oder sogar im Patienten getestet. In diesem Kapitel wird der Stand der Forschung an Organoiden in der Zelltherapie zusammengefasst.
AAV-Vektoren – die imposante Karriere eines Parvovirus
Authors: Jäschke Nico Martin , Büning Hildegard 
Published: December 2023

ZusammenfassungAAV-Vektoren gelten als die derzeit besten Genfähren für die In-vivo-Gentherapie. Aber was ist ihr Ursprung, was macht sie so besonders und wie interagieren sie mit ihrer Umgebung oder mit Wirtszellen? Lassen Sie uns zunächst diese Punkte näher beleuchten, bevor wir Beispiele für ihre Anwendungen besprechen.
Technologien und Lösungsansätze für die effiziente Herstellung von Zelltherapeutika für die CAR-Immuntherapie
Authors: Blache Ulrich , Kebbel Kati , Quaiser Andrea , Popp Georg , Franz Paul , Dünkel Anna , Thoma Martin , König Niels , Platzbecker Uwe , Schmiedeknecht Gerno , Fricke Stephan , Köhl Ulrike 
Published: December 2023

ZusammenfassungDie dynamischen Entwicklungen auf dem Gebiet der zellulären Immuntherapie, insbesondere im Bereich der CAR-T-Zellen, ermöglichen neue Erfolg versprechende Behandlungsoptionen von Krebserkrankungen. Zugleich stellen diese noch jungen Krebstherapien die Medizin vor große Herausforderungen. Wie die Herstellung von zellulären Krebstherapeutika im großen Maßstab zur Versorgung der wachsenden Patientenzahl in der Zukunft gewährleistet werden kann und welche Hürden es dabei zu überwinden gilt, wird im Folgenden adressiert. Erste Optionen zur automatisierten Herstellung von CAR-T-Zellen sind bereits etabliert. Um zukünftig die Behandlung großer Patientengruppen zu gewährleisten, sind neue Herstellungstechnologien wie allogene Zellquellen, digital gesteuerte Prozessstraßen und automatische Qualitätskontrollen erforderlich.
Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis
Authors: Aytenew Tigabu Munye , Demis Solomon , Birhane Binyam Minuye , Asferie Worku Necho , Simegn Amare , Nibret Gedefaye , Kassaw Amare , Asnakew Sintayehu , Tesfahun Yohannes , Andualem Henock , Bantie Berihun , Kassaw Gebrie , Kefale Demewoz , Zeleke Shegaw 
Published: December 2023

AbstractHuman immunodeficiency virus remains a global public health problem. Despite efforts to determine the prevalence of non-adherence to ART and its predictors in Ethiopia, various primary studies presented inconsistent findings. Therefore, this review aimed to determine the pooled prevalence of non-adherence to ART and identify its predictors. We have searched PubMed, Google Scholar and Web of Science databases extensively for all available studies. A weighted inverse-variance random-effects model was used to compute the overall non-adherence to ART. The pooled prevalence of non-adherence to ART was 20.68% (95% CI: 17.74, 23.61); I2 = 98.40%; p < 0.001). Educational level of primary school and lower [AOR = 3.5, 95%CI: 1.7, 7.4], taking co-medications [AOR = 0.45, 95%CI: 0.35, 0.59], not using memory aids [AOR = 0.30, 95%CI: 0.13, 0.71], depression [AOR = 2.0, 95%CI: 1.05, 3.79], comorbidity [AOR = 2.12, 95%CI: 1.16, 3.09), under-nutrition [AOR = 2.02, 95%CI: 1.20, 3.43], not believing on ART can control HIV [AOR = 2.31, 95%CI: 1.92, 2.77], lack of access to health facilities [AOR = 3.86, 95%CI: 1.10, 13.51] and taking ART pills uncomfortably while others looking [AOR = 5.21, 95%CI: 2.56, 10.53] were significantly associated with non-adherence to anti-retroviral therapy. The overall pooled prevalence of non-adherence to ART was considerably high in Ethiopia. Educational status, taking co-medications, not using memory aids, depression, comorbidity, under nutrition, not believing on anti-retroviral therapy controls HIV, lack of access to health facilities and taking ART pills uncomfortably were independent predictors of non-adherence to ART in Ethiopia. Therefore, healthcare providers, adherence counselors and supporters should detect non-adherence behaviors and patients’ difficulties with ART early, and provide intensive counseling to promote adherence.
The Feeling Rules of Peer Review: Defining, Displaying, and Managing Emotions in Evaluation for Research Funding
Authors: Brunet Lucas , Müller Ruth 
Published: December 2023

AbstractPunctuated by joy, disappointments, and conflicts, research evaluation constitutes an intense, emotional moment in scientific life. Yet reviewers and research institutions often expect evaluations to be conducted objectively and dispassionately. Inspired by the scholarship describing the role of emotions in scientific practices, we argue instead, that reviewers actively define, display and manage their emotions in response to the structural organization of research evaluation. Our article examines reviewing practices used in the European Research Council’s (ERC) Starting and Consolidator grants and in the Marie Skłodowska-Curie Action’s (MSCA) Individual Fellowships. These two European funding mechanisms offer different perspectives on the organization of grant evaluation. We conducted interviews with review panel members and analyzed various institutional documents. By drawing on the sociological concepts of feeling rules and emotional work, we demonstrate that reviewers define rules concerning how emotions should be experienced and expressed to ensure the proper functioning of evaluation, and that reviewers experience the need to actively regulate their emotions to comply with these rules. We present four feeling rules concerning the experience and expression of: (1) excitement for novelty during individual evaluation; (2) respect for others’ opinions and the absence of anger in review panels; (3) attentiveness and interest, which are seen as missing in online evaluations. Reviewers also expect ERC candidates to (4) avoid pride and manifest modesty during interviews. These rules demonstrate that proposal peer review is governed by emotional norms, and show the influence of organizational settings and moral requirements on research evaluation.
Suppression of deep-level traps via semicarbazide hydrochloride additives for high-performance tin-based perovskite solar cells
Authors: Jia Wenbo , Jing Yi , Zhang Han , Tian Baoyan , Huang Huabo , Wang Changlei , Xu Ligang 
Published: December 2023

Abstract
Tin perovskites with exemplary optoelectronic properties offer potential application in lead-free perovskite solar cells. However, Sn vacancies and undercoordinated Sn ions on the tin perovskite surfaces can create deep-level traps, leading to non-radiative recombination and absorption of nucleophilic O2 molecules, impeding further device efficiency and stability. Here, in this study, a new additive of semicarbazide hydrochloride (SEM-HCl) with a N–C=O functional group was introduced into the perovskite precursor to fabricate high-quality films with a low concentration of deep-level trap densities. This, in turn, serves to prevent undesirable interaction between photogenerated carriers and adsorbed oxygen molecules in the device’s operational environment, ultimately reducing the proliferation of superoxide entities. As the result, the SEM-HCl-derived devices show a peak efficiency of 10.9% with improved device stability. These unencapsulated devices maintain almost 100% of their initial efficiencies after working for 100 h under continuous AM1.5 illumination conditions.

Graphical Abstract
From Pharmaceutical Innovation to Revenue Generation: The Asian Experience
Authors: Basak Subir Kumar 
Published: December 2023

AbstractAsia’s pharmaceutical sector has experienced remarkable growth over the last two decades, with companies in the region producing bulk of the world’s specialty generics, biologicals, and active pharmaceutical ingredients (APIs). The Asian pharma growth story has had several pillars for a strong and sustainable foundation that provided non-linear growth. This report introduces three models showing how Asian countries at different development stages — India, South Korea, and Singapore — have nurtured their own, self-sustaining pharmaceutical sectors.
A Model‐Data Comparison of the Hydrological Response to Miocene Warmth: Leveraging the MioMIP1 Opportunistic Multi‐Model Ensemble
Authors: Acosta R. P. , Burls N. J. , Pound M. J. , Bradshaw C. D. , De Boer A. M. , Herold N. , Huber M. , Liu X. , Donnadieu Y. , Farnsworth A. , Frigola A. , Lunt D. J. , von der Heydt A. S. , Hutchinson D. K. , Knorr G. , Lohmann G. , Marzocchi A. , Prange M. , Sarr A. C. , Li X. , Zhang Z. 
Published: December 2023

AbstractThe Miocene (23.03–5.33 Ma) is recognized as a period with close to modern‐day paleogeography, yet a much warmer climate. With large uncertainties in future hydroclimate projections, Miocene conditions illustrate a potential future analog for the Earth system. A recent opportunistic Miocene Model Intercomparison Project 1 (MioMIP1) focused on synthesizing published Miocene climate simulations and comparing them with available temperature reconstructions. Here, we build on this effort by analyzing the hydrological cycle response to Miocene forcings across early‐to‐middle (E2MMIO; 20.03–11.6 Ma) and middle‐to‐late Miocene (M2LMIO; 11.5–5.33 Ma) simulations with CO2 concentrations ranging from 200 to 850 ppm and providing a model‐data comparison against available precipitation reconstructions. We find global precipitation increases by ∼2.1 and 2.3% per degree of warming for E2MMIO and M2LMIO simulations, respectively. Models generally agree on a wetter than modern‐day tropics; mid and high‐latitude, however, do not agree on the sign of subtropical precipitation changes with warming. Global monsoon analysis suggests most monsoon regions, except the North American Monsoon, experience higher precipitation rates under warmer conditions. Model‐data comparison shows that mean annual precipitation is underestimated by the models regardless of CO2 concentration, particularly in the mid‐ to high‐latitudes. This suggests that the models may not be (a) resolving key processes driving the hydrological cycle response to Miocene boundary conditions and/or (b) other boundary conditions or processes not considered here are critical to reproducing Miocene hydroclimate. This study highlights the challenges in modeling and reconstructing the Miocene hydrological cycle and serves as a baseline for future coordinated MioMIP efforts.
Ecosystemic Clinical Assessment of Linguistic Diversity: Greek-Dominant Speech
Authors: Babatsouli Elena 
Published: December 2023

Purpose:
Diversity considerations are of paramount significance in the clinical assessment and treatment of speech disorders in bilingual children and adults who speak a less common language (and/or its dialects). While comprehensive assessment is essential for culturally and linguistically diverse (CLD) populations, this is clinically challenging due to the indeterminacy entailed in the process and incumbrances in access to resources. This clinical tutorial outlines key considerations necessary for holistic, ecological, and dynamic assessments of speech disorders internationally, focusing on Greek.

Method:
Pertinent literature is reviewed to provide the relevant theoretical backdrop for the ecosystemic protocol, both conceptually and schematically. Greek is utilized as an example language, aiming to underscore knowledge, tools, and other resources on clinically relevant aspects of dialectal, interlanguage (adult second language [L2]), and child multilingual (L2/third language) variation in Greek-dominant speakers.

Results:
The tutorial highlights facets of Greek speech and scripts a primary assessment model for clinical use mostly targeting clinicians that are not speakers or cognizant of the language, also viewing speech in linguistic diversity as a sociolinguistic construct. Recommendations for clinical practices are outlined proposing a specific action plan, exemplified by a case scenario.

Conclusions:
The demonstrated ecosystemic paradigm in holistic, ecological protocols for clinical assessment of speech disorder in CLD speakers addresses the need for nonlinear, multilevel assessment of variable language exposure and use; being sensitive to individual speaker specificities; the sociolinguistic environment; and employing people-first, culturally sensitive, and dynamic strategies in clinical assessment. The stance also simplifies disambiguation tasks regarding the difference disorder dichotomy, enhancing existing clinical procedures.
Bullet ricochet mark plan-view morphology in concrete: an experimental assessment of five bullet types and two distances using machine learning
Authors: Eren Metin I , Romans Jay , Walker Robert S , Buchanan Briggs , Key Alastair 
Published: December 2023

Abstract Bullet ricochets are common occurrences during shooting incidents and can provide a wealth of information useful for shooting incident reconstruction. However, there have only been a small number of studies that have systematically investigated bullet ricochet impact site morphology. Here, this study reports on an experiment that examined the plan-view morphology of 297 ricochet impact sites in concrete that were produced by five different bullet types shot from two distances. This study used a random forest machine learning algorithm to classify bullet types with morphological dimensions of the ricochet mark (impact) with length and perimeter-to-area ratio emerging as the top predictor variables. The 0.22 LR leaves the most distinctive impact mark on the concrete, and overall, the classification accuracy using leave-one-out cross-validation is 62%, considerably higher than a random classification accuracy of 20%. Adding in distance to the model as a predictor increases the classification accuracy to 66%. These initial results are promising, in that they suggest that an unknown bullet type can potentially be determined, or at least probabilistically assessed, from the morphology of the ricochet impact site alone. However, the substantial amount of overlap this study documented among distinct bullet types’ ricochet mark morphologies under highly controlled conditions and with machine learning suggests that the human identification of ricochet marks in real-world shooting incident reconstructions may be on occasion, or perhaps regularly, in error.Key points
Effects of the care given to intensive care patients using an evidence model on the prevention of central line-associated bloodstream infections
Authors: Şanlı Deniz , Sarıkaya Aklime , Pronovost Peter J 
Published: December 2023

Abstract
It is important to put evidence-based guidelines into practice in the prevention of central line-associated bloodstream infections in intensive care patients. In contrast to expensive and complex interventions, a care bundle that includes easy-to-implement and low-cost interventions improves clinical outcomes. The compliance of intensive care nurses with guidelines is of great importance in achieving these results. The Translating Evidence into Practice Model provides guidance in how to implement the necessary guidelines. This quasi-experimental study used a post-test control group design in nonequivalent groups and was conducted in the anesthesia intensive care unit of a tertiary-level training and research hospital. All patients who were hospitalized in the intensive care unit, who had a central line during the study, and who met the inclusion criteria were included in the sample. The care bundle comprised education, and protocols for hand hygiene and the aseptic technique, maximum sterile barrier precautions, central line insertion trolley, and management of nursing care. To analyze the data, the independent samples t-test, the Mann-Whitney U test, chi-square test, dependent samples t-test, rate ratio, and relative risk were used with 95% confidence intervals. The rate of central line-associated bloodstream infections was significantly lower in the intervention group (2.85/1000 central line days) than in the control group (3.35/1000 central line days) (P = 0.042). The number of accesses to the central line by the nurses decreased significantly in the intervention group compared to the control group (P &lt; 0.001). The mean score for the nurses’ evidence-based guideline post-education knowledge (70.80 ± 12.26) was significantly higher than that pre-education (48.20 ± 14.66) (P &lt; 0.001). Compliance with the guideline recommendations in central line-related nursing interventions and in the central line insertion process was significantly better in the intervention group than in the control group in many interventions (P &lt; 0.05). The mean score for the nurses’ attitude towards evidence-based nursing increased significantly over time (59.87 ± 7.23 at the 0th month; 63.79 ± 7.24 at the 6th month) (P &lt; 0.001). Nursing care given by implementing the central line care bundle with the Translating Evidence into Practice Model affected the measures. Thanks to the implementation of the care bundle, the rate of infections and the number of accesses to the central line decreased, while the critical care nurses’ knowledge of evidence-based guidelines, compliance with the guideline recommendations in central line-related nursing interventions, and attitudes towards evidence-based nursing improved.