bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose Tissue Targeting Ultra‐Small Hybrid Nanoparticles for Synergistic Photodynamic Therapy and Browning Induction in Obesity Treatment
Authors: Ma Chuan , Jian Chuanjiang , Guo Lihao , Li Wenting , Zhang Cai , Wang Li , Yuan Miaomiao , Zhang Peng , Dong Jinqiao , He Ping , Shi Leilei 
Published: November 2023

AbstractPhotodynamic therapy (PDT), as a means of locally and rapidly inducing adipocyte death via light illumination, in combination with adipose browning induction, a more gradual and widespread effect that could transform white adipose tissue into thermogenic adipose tissue, manifests a promising approach to combat obesity. Herein, adipose‐targeting ultra‐small hybrid nanoparticles (Pep‐PPIX‐Baic NPs) composed of an adipose‐targeting peptide, Fe3+, a photosensitizer (protoporphyrin IX), and a browning agent (baicalin) are introduced. Pep‐PPIX‐Baic NPs have been designed to simultaneously enhance the photodynamic effect and induce browning. After intravenous injection in obese mice, the hybrid nanoparticles can specifically accumulate in white adipose tissues, especially those rich in blood supply, and drive adipose reduction owing to the synergy of the PDT effect and baicalin browning induction. Overall, Pep‐PPIX‐Baic NPs exhibited superior anti‐obesity potential through PDT synergistic with adipose browning induction. The designed multifunctional adipose‐targeting hybrid nanoparticles present a prospective nanoplatform for obesity treatment.
Could a minimalist lifestyle reduce carbon emissions and improve wellbeing? A review of minimalism and other low consumption lifestyles
Authors: Blackburn Rebecca , Leviston Zoe , Walker Iain , Schram Ashley 
Published: November 2023

AbstractEveryone must consume, but the wealthy consume more than most. Half of global household emissions come from the world's top 10% of income earners. In this review, we investigate the minimalist lifestyle to find out if minimalism could deliver the dual benefit of reduced carbon emissions and increased wellbeing. Minimalists have voluntarily chosen to have few possessions, despite economic and social structures that encourage consumption. Having fewer possessions suggests they might have a lower carbon emissions. A review of three other low‐consumption lifestyles: frugalism, tightwadism and voluntary simplicity, offers some support for this hypothesis, but the empirical evidence regarding minimalism is scant. We also review minimalist motivations, finding some support for a positive association between wellbeing and minimalism. We conclude that while minimalism might offer wellbeing benefits, research on carbon emissions is inconclusive. Furthermore, even if minimalism did result in reduced emissions, the minimalist lifestyle maybe too individualistic to create social change.This article is categorized under:
Perceptions, Behavior, and Communication of Climate Change > Behavior Change and Responses
The Carbon Economy and Climate Mitigation > Policies, Instruments, Lifestyles, Behavior
Climate and Development > Sustainability and Human Well‐Being
Sexual Consent and Its Contexts
Authors: Featherstone Lisa , Byrnes Cassandra , Maturi Jenny , Minto Kiara , Mickelburgh Renée , Donaghy Paige 
Published: November 2023

AbstractConsent is more complicated than a simple ‘yes’ or ‘no’. This chapter serves as an introduction to many of the central ideas around consent in current cultures. It identifies the ways consent, violence, and coercion were and are conceptualised. It seeks to problematise simple concepts of consent and to highlight the ways power and authority influence consent. Our contemporary landscape retains important historical legacies that have left significant holes in social ideas of bodily authority and sexual autonomy. To better understand these gaps and omissions, this chapter traces the long history of consent and non-consent within social, cultural, and legal frameworks. For instance, across the nineteenth century, expectations of physical violence and force were slowly written out of the statutes surrounding rape: consent, rather than physical violence, became the criteria that distinguished sexual assault. Nonetheless, in the absence of physical violence, it remained almost impossible to convict an offender of rape, and force remained central to the way rape was ‘proven’ at trial. As this chapter explores, ideas about consent shifted over time and place, but many understandings remained resistant to change.
Consent in Refugee and Migrant Communities
Authors: Featherstone Lisa , Byrnes Cassandra , Maturi Jenny , Minto Kiara , Mickelburgh Renée , Donaghy Paige 
Published: November 2023

AbstractApproaches to gendered violence are generally based on a rights approach, encouraging women to seek help from the criminal justice system and services that might support them. But a victim’s rights approach to sexual violence and consent is only effective if women see those rights mirrored back at them in the help and protections they seek. Drawing on data from 19 semi-structured interviews with refugee and migrant antiviolence advocates in Australia, this chapter uses Sally Merry’s (Merry, Human Rights Quarterly 25:343–381, 2003) concept of a ‘rights consciousness’ to explore the tensions women might experience when problems related to gender are presented as a legal issue. Highlighting the tensions refugee and migrant women might face between taking on a rights defined self, and a self tied to family, kin and community, the findings explore three themes: “Marriage is Consent”, “Loyalty to Men”, and “Experiences with Justice”. Taken together, these findings advance the need to consider sexual violence and consent not just in individualistic legal terms, but as an issue of social justice that considers broader, intersecting inequalities. Rather than encouraging women to take up their rights, efforts should focus on how to ensure a rights approach is affirmed in responses to sexual violence and consent.
Light-cone gauge in non-relativistic AdS5×S5 string theory
Authors: Fontanella Andrea , Nieto García Juan Miguel 
Published: November 2023

Abstract
We discuss the non-relativistic limit of string theory in AdS5×S5 for different choices of embedding coordinates. We show that, if we consider Cartesian coordinates, the action of fluctuations around the twisted BMN-like string found in arXiv:2109.13240 in uniform light-cone gauge becomes the one of free fields at large string tension and large AdS5 radius.
On mixed-flux worldsheet scattering in AdS3/CFT2
Authors: Frolov Sergey , Polvara Davide , Sfondrini Alessandro 
Published: November 2023

Abstract
Strings on AdS3 × S3 × T4 with mixed Ramond-Ramond and Neveu-Schwarz-Neveu-Schwarz flux are known to be classically integrable. This is a crucial property of this model, which cannot be studied by conventional worldsheet-CFT techniques. Integrability should carry over to the quantum level, and the worldsheet S matrix in the lightcone gauge is known up to the so-called dressing factors. In this work we study the kinematics of mixed-flux theories and consider a relativistic limit of the S matrix whereby we can complete the bootstrap program, including the dressing factors for fundamental particles and bound states. This provides an important test for the dressing factors of the full worldsheet model, and offers new insights on the features of the model when the amount of NSNS flux is low.
New constraint on dark photon at T2K off-axis near detector
Authors: Araki Takeshi , Asai Kento , Iizawa Tomoya , Otono Hidetoshi , Shimomura Takashi , Takubo Yosuke 
Published: November 2023

Abstract
The T2K experiment is one of the most powerful long-baseline experiments to investigate neutrino oscillations. The off-axis near detector called ND280 is installed 280 m downstream from the neutrino production target to measure the neutrino energy spectrum. In this paper, we study the capability of the ND280 detector to search for the dark photon produced through the meson rare decay and proton bremsstrahlung processes at the proton beam dump. We find that the ten-year operation of T2K with the ND280 detector excludes the unexplored parameter region for the dark photon mass and kinetic mixing. We also show that a broader parameter region can be searched by the ND280 in the future T2K operation for dark photon as well as U(1)B−L gauge boson.
Gyroscopic gravitational memory
Authors: Seraj Ali , Oblak Blagoje 
Published: November 2023

Abstract
We study the motion of a gyroscope located far away from an isolated gravitational source in an asymptotically flat spacetime. As seen from a local frame tied to distant stars, the gyroscope precesses when gravitational waves cross its path, resulting in a net ‘orientation memory’ that carries information on the wave profile. At leading order in the inverse distance to the source, the memory consists of two terms: the first is linear in the metric perturbation and coincides with the spin memory effect, while the second is quadratic and measures the net helicity of the wave burst. Both are closely related to symmetries of the gravitational radiative phase space at null infinity: spin memory probes superrotation charges, while helicity is the canonical generator of local electric-magnetic duality on the celestial sphere.
Visualization and efficient generation of constrained high-dimensional theoretical parameter spaces
Authors: Baretz Jason , Carrara Nicholas , Hollingsworth Jacob , Whiteson Daniel 
Published: November 2023

Abstract
We describe a set of novel methods for efficiently sampling high-dimensional parameter spaces of physical theories defined at high energies, but constrained by experimental measurements made at lower energies. Often, theoretical models such as supersymmetry are defined by many parameters, $$ \mathcal{O} $$
O
(10 − 100), expressed at high energies, while relevant experimental constraints are often defined at much lower energies, preventing them from directly ruling out portions of the space. Instead, the low-energy constraints define a complex, potentially non-contiguous subspace of the theory parameters. Naive scanning of the theory space for points which satisfy the low-energy constraints is hopelessly inefficient due to the high dimensionality, and the inverse problem is considered intractable. As a result, many theoretical spaces remain under-explored. We introduce a class of modified generative autoencoders, which attack this problem by mapping the high-dimensional parameter space to a structured low-dimensional latent space, allowing for easy visualization and efficient generation of theory points which satisfy experimental constraints. An extension without dimensional compression, which focuses on limiting potential information loss, is also introduced.
AdS Virasoro-Shapiro amplitude with KK modes
Authors: Fardelli Giulia , Hansen Tobias , Silva Joao A. 
Published: November 2023

Abstract
We determine the first curvature correction for the string amplitude of two supergravity states and two Kaluza-Klein modes on AdS5×S5, which is dual to the correlator $$ \left\langle {\mathcal{O}}_2{\mathcal{O}}_2{\mathcal{O}}_p{\mathcal{O}}_p\right\rangle $$

O
2

O
2

O
p

O
p

of half-BPS operators in $$ \mathcal{N} $$
N
= 4 SYM theory. The result has the form of an integral over the Riemann sphere as for the usual Virasoro-Shapiro amplitude, with the insertion of single-valued multiple polylogarithms of weight three. The result fixes OPE data of single-trace operators in $$ \mathcal{N} $$
N
= 4 SYM theory at strong coupling, including operators with non-zero R-charge and odd spin. We successfully check our results by comparing to data available from integrability, localisation and consistency with a 10d effective action.
miR-455-5p promotes pathological cardiac remodeling via suppression of PRMT1-mediated Notch signaling pathway
Authors: Cai Sidong , Chang Junlei , Su Mengqi , Wei Yinxia , Sun Haoran , Chen Cong , Yiu Kai-Hang 
Published: November 2023

AbstractPathological cardiac remodeling plays an essential role in the progression of cardiovascular diseases, and numerous microRNAs have been reported to participate in pathological cardiac remodeling. However, the potential role of microRNA-455-5p (miR-455-5p) in this process remains to be elucidated. In the present study, we focused on clarifying the function and searching the direct target of miR-455-5p, as well as exploring its underlying mechanisms in pathological cardiac remodeling. We found that overexpression of miR-455-5p by transfection of miR-455-5p mimic in vitro or tail vain injection of miR-455-5p agomir in vivo provoked cardiac remodeling, whereas genetic knockdown of miR-455-5p attenuated the isoprenaline-induced cardiac remodeling. Besides, miR-455-5p directly targeted to 3’-untranslated region of protein arginine methyltransferase 1 (PRMT1) and subsequently downregulated PRMT1 level. Furthermore, we found that PRMT1 protected against cardiac hypertrophy and fibrosis in vitro. Mechanistically, miR-455-5p induced cardiac remodeling by downregulating PRMT1-induced asymmetric di-methylation on R1748, R1750, R1751 and R1752 of Notch1, resulting in suppression of recruitment of Presenilin, Notch1 cleavage, NICD releasing and Notch signaling pathway. Finally, circulating miR-455-5p was positively correlated with parameters of left ventricular wall thickening. Taken together, miR-455-5p plays a provocative role in cardiac remodeling via inactivation of the PRMT1-mediated Notch signaling pathway, suggesting miR-455-5p/PRMT1/Notch1 signaling axis as potential therapeutic targets for pathological cardiac remodeling.
Treatment of myopic choroidal neovascularization: a network meta-analysis and review
Authors: Glachs Laura , Embacher Stefan , Berghold Andrea , Wildner Brigitte , Michelitsch Monja , Tscherne Anna , Wedrich Andreas , Posch-Pertl Laura 
Published: November 2023

Abstract
Purpose
This is, to our knowledge, the first network meta-analysis aiming to compare all treatment modalities for myopic choroidal neovascularization (CNV).

Methods
After the electronic databases were searched, two independent reviewers screened titles, abstracts, full-texts, and extracted information. Primary endpoints were change in visual outcome and central retinal thickness. We used a network meta-analysis to compare treatment outcomes in the early (≤ 6 months) and late (> 6 months) phase.

Results
We included 34 studies (2,098 eyes) in our network meta-analysis. In the early phase, the use of anti-VEGF led to a gain of 14.1 letters (95% CI, 10.8–17.4) compared to untreated patients (p < 0.0001), 12.1 letters (95% CI, 8.3–15.8) to photodynamic therapy (PDT) (p < 0.0001), 7.5 (95% CI, 1.2–13.8) letters to intravitreal triamcinolone acetonide (TCA) (p = 0.019), and − 2.9 letters (95% CI, − 6.0–0.2) to the combination of anti-VEGF and PDT (p = 0.065). In the later phase, these results were largely maintained. There were no significant differences in visual outcomes between patients treated with 1 + PRN and 3 + PRN. However, the 1 + PRN group received 1.8 (SD 1.3), while the 3 + PRN group received 3.2 (SD 0.9) injections within 12 months (p < 0.0001).

Conclusion
This network meta-analysis confirms that anti-VEGF is the most effective treatment for myopic CNV using the 1 + PRN treatment strategy.
Achilles tendon and triceps surae muscle properties in athletes
Authors: Sukanen Maria , Khair Ra’ad M. , Ihalainen Johanna K. , Laatikainen-Raussi Iida , Eon Pauline , Nordez Antoine , Finni Taija 
Published: November 2023

Abstract
Purpose
The aim of this study was to investigate internal Achilles tendon (AT) displacement, AT shear wave velocity (SWV), and triceps surae (TS) muscle shear modulus in athletes.

Methods
Internal AT displacement was assessed using ultrasound during isometric contraction. Shear wave elastography was used to assess AT SWV (m × s–1) at rest and TS muscle shear modulus (kPa) during passive ankle dorsiflexion.

Results
A total of 131 athletes participated in this study. Athletes who had not exercised within two days had greater AT non-uniformity and mean anterior tendon displacement, and lower SWV at the proximal AT measurement site (mean difference [95% CI]: 1.8 mm [0.6–2.9], p = 0.003; 1.6 mm [0.2–2.9], p = 0.021; – 0.9 m × s–1 [– 1.6 to – 0.2], p = 0.014, respectively). Male basketball players had a lower mean AT displacement compared to gymnasts (– 3.7 mm [– 6.9 to – 0.5], p = 0.042), with the difference localised in the anterior half of the tendon (– 5.1 mm [– 9.0 to – 1.1], p = 0.022). Male gymnasts had a smaller absolute difference in medial gastrocnemius-minus-soleus shear modulus than basketball players (59.6 kPa [29.0–90.2], p < 0.001) and track and field athletes (52.7 kPa [19.2–86.3], p = 0.004). Intraclass correlation coefficients of measurements ranged from 0.720 to 0.937 for internal AT displacement, from 0.696 to 0.936 for AT SWE, and from 0.570 to 0.890 for TS muscles.

Conclusion
This study provides a reliability assessment of muscle and tendon SWV. The relative differences in passive TS muscle shear modulus suggest sport-specific adaptation. Importantly, in healthy individuals, lower AT displacement after exercise may reflect the time required for tendon recovery.
Evaluating fertility preservation interventions for alignment with ASCO Guidelines for reproductive aged women undergoing cancer treatment: a systematic review
Authors: Pathak Sarita , Vadaparampil Susan T. , Sutter Megan E. , Rice Whitney S. , McBride Colleen M. 
Published: November 2023

Abstract
Purpose
While cancer treatment advancements have increased the number of reproductive-aged women survivors, they can harm reproductive function. Despite national guidelines, oncofertility service uptake remains low. This review explores interventions for fertility preservation alignment with American Society of Clinical Oncology (ASCO) guidelines and consideration of a multilevel framework.

Methods
We systematically reviewed literature from 2006 to 2022 across four databases. Identified interventions were assessed and scored for quality based on CONSORT and TREND statement checklists. Results were synthesized to assess for intervention alignment with ASCO guidelines and four multilevel intervention framework characteristics: targeted levels of influence, conceptual clarity, methodologic pragmatism, and sustainability.

Results
Of 407 articles identified, this review includes nine unique interventions. The average quality score was 7.7 out of 11. No intervention was guided by theory. Per ASCO guidelines, most (n=8) interventions included provider-led discussions of treatment-impaired fertility. Fewer noted discussions on fertility preservation approaches (n=5) and specified discussion timing (n=4). Most (n=8) referred patients to reproductive specialists, and few (n=2) included psychosocial service referrals. Most (n=8) were multilevel, with five targeting three levels of influence. Despite targeting multiple levels, all analyses were conducted at the individual level. Intervention strategies included: educational components (n=5), decision aids (n=2), and nurse navigators (n=2). Five interventions considered stakeholders’ views. All interventions were implemented in real-world contexts, and only three discussed sustainability.

Conclusions
This review identifies key gaps in ASCO guideline-concordant fertility preservation that could be filled by updating and adhering to standardized clinical practice guidelines and considering multilevel implementation frameworks elements.
Validity and screening capacity of the FCR-1r for fear of cancer recurrence in long-term colorectal cancer survivors
Authors: Lyhne Johanne Dam , Smith Allan “Ben” , Timm Signe , Simard Sébastien , Jensen Lars Henrik , Frostholm Lisbeth , Fink Per 
Published: November 2023

Abstract
Purpose
Existing fear of cancer recurrence (FCR) screening measures is being shortened to facilitate clinical use. This study aimed to evaluate the validity and screening capacity of a single-item FCR screening measure (FCR-1r) in long-term colorectal cancer (CRC) survivors with no recurrence and assess whether it performs as well in older as in younger survivors.

Methods
All Danish CRC survivors above 18, diagnosed and treated with curative intent between 2014 and 2018, were located through a national patient registry. A questionnaire including the FCR-1r, which measures FCR on a 0–10 visual analog scale, alongside the validated Fear of Cancer Recurrence Inventory Short Form (FCRI-SF) as a reference standard was distributed between November 2021 and May 2023. Screening capacity and cut-offs were evaluated with a receiver-operating characteristic analysis (ROC) in older (≥ 65 years) compared to younger (< 65 years) CRC survivors. Hypotheses regarding associations with other psychological variables were tested as indicators of convergent and divergent validity.

Results
Of the CRC survivors, 2,128/4,483 (47.5%) responded; 1,654 (36.9%) questionnaires were eligible for analyses (median age 76 (range 38–98), 47% female). Of the responders, 85.2% were aged ≥ 65. Ninety-two participants (5.6%) reported FCRI-SF scores ≥ 22 indicating clinically significant FCR. A FCR-1r cut-off ≥ 5/10 had 93.5% sensitivity and 80.4% specificity for detecting clinically significant FCR (AUC = 0.93, 95% CI 0.91–0.94) in the overall sample. The discrimination ability was significantly better in older (AUC = 0.93, 95% CI 0.91–0.95) compared to younger (0.87, 95% (0.82–0.92), p = 0.04) CRC survivors. The FCR-1r demonstrated concurrent validity against the FCRI-SF (r = 0.71, p < 0.0001) and convergent validity against the short-versions of the Symptom Checklist-90-R subscales for anxiety (r = 0.38, p < 0.0001), depression (r = 0.27, p < 0.0001), and emotional distress (r = 0.37, p < 0.0001). The FCR-1r correlated weakly with employment status (r =  − 0.09, p < 0.0001) and not with marital status (r = 0.01, p = 0.66) indicating divergent validity.

Conclusions
The FCR-1r is a valid tool for FCR screening in CRC survivors with excellent ability to discriminate between clinical and non-clinical FCR, particularly in older CRC survivors.
Bone mineral density differences between femurs of scoliotic patients undergoing quantitative computed tomography analysis
Authors: Albano Domenico , Fusco Stefano , Mascitti Laura , Buccimazza Giorgio , Gallazzi Enrico , Gitto Salvatore , Sconfienza Luca Maria , Messina Carmelo 
Published: November 2023

Abstract
Purpose
Scoliosis is a cause of loading imbalance between the lower limbs, which can result in BMD differences between the two femurs. We investigated the discrepancy in BMD values assessed by quantitative computed tomography (QCT) between femurs in patients with and without scoliosis, also assessing if this difference can be related to spine convexity.

Methods
Abdominal CT examinations were retrospectively reviewed. An ‘‘asynchronous’’ calibration of CT images was performed to obtain BMD values from QCT. Scoliosis was evaluated on the antero-posterior CT localizer to calculate the Cobb angle. Differences between aBMD and vBMD of femurs were assessed in both scoliotic and non-scoliotic subjects.

Results
Final study cohort consisted of 263 subjects, 225 of them without scoliosis (85.6%) and 38 with scoliosis (14.4%). No significant differences were found in the general population without scoliosis, except for vBMD at the neck. Comparison of femurs in scoliotic patients showed statistically significant differences at neck aBMD −0.028 g/cm2, p = 0.004), total femur aBMD (−-0.032 g/cm2, p = 0.008) and total femur vBMD (−-8.9 mg/cm3, p = 0.011), with lower BMD values on the convexity side. In 10 cases (26%) a change in the final T-score diagnosis was observed.

Conclusion
QCT analysis demonstrated a difference in both areal and volumetric BMD between the two femurs of scoliotic patients, in relation to the side of the scoliotic curve. If these data will be confirmed by larger studies, bilateral femoral DXA acquisition may be proposed for these patients.