bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lyme neuroborreliosis as initial expression of Lyme disease in an elderly patient
Authors: Mata Emidio , Lage Garcia Bárbara , Pereira André , Rego Joana , Santos Flávia , Fernandes Carlos , Cotter Jorge 
Published: February 2025

Background: Lyme disease (LD) is a multisystemic infection caused by Borrelia burgdorferi and transmitted by Ixodes ticks, affecting the skin, nervous system, heart and joints. Neuroborreliosis (LNB), a nervous system manifestation of LD, occurs in 10–15% of cases and may present with neurological symptoms at varying stages. Case description: We present the case of an 84-year-old man, admitted to the emergency department following a seizure, with fever and oropharyngeal erythema. After the administration of penicillin for presumed tonsillitis, a generalised skin rash developed and spontaneously resolved after 4 hours. Within 24 hours, two well-defined round erythematous lesions were observed on the neck and shoulder. Due to new onset of confusion and lethargy a lumbar puncture was performed, revealing polymorphonuclear pleocytosis, elevated protein levels and normal glucose. An empirical ceftriaxone course was started for suspected neuroborreliosis. Neuroborreliosis was diagnosed based on the clinical presentation of fever and neurological changes, with supporting cutaneous manifestations and compatible Borrelia burgdorferi serology. The initial rash was interpreted as a Jarisch–Herxheimer reaction, and the two skin lesions were classified as erythema migrans. After completing treatment, the patient made a full recovery. Conclusion: This case underscores the diagnostic complexity of LNB as an initial manifestation of LD, particularly in elderly patients. Early neurological symptoms, often preceding classic cutaneous signs, may lead to diagnostic delays. This highlights the importance of maintaining clinical suspicion for LD, given the limitations of serological and cerebrospinal fluid (CSF) testing. Prompt recognition and intervention are essential to prevent progression and ensure favourable outcomes.
Multidisciplinary management of a patient with acute oesophageal necrosis and severe neurological symptoms with full recovery
Authors: Terehova Katrīna , Zaļizko Poļina , Lazdovska Krista , Skumbiņš Raimonds , Puķītis Aldis 
Published: February 2025

Background: Acute oesophageal necrosis is a rare and poorly understood disorder of the oesophagus. It poses significant diagnostic and therapeutic challenges as it often presents with multiple comorbidities and a poor prognosis. Case report: We report a case of 42-year-old male with no significant medical history, who presented to our clinic due to neurological deficits and repeated vomiting for 2 weeks. He initially denied alcohol abuse. Upper endoscopy demonstrated circular black discoloration of the distal oesophagus. The patient was treated with proton pump inhibitors and received treatment for his comorbidities. Esophagogastroduodenoscopy was performed to assess improvement. The patient’s symptoms gradually resolved. Conclusion: This case is one of the few to show an association between alcohol abuse and acute oesophageal necrosis and underscores the importance of timely diagnosis and multidisciplinary treatment in patient with fully recovered condition.
Pseudomonas mendocina bacteraemia secondary to cellulitis – a report and brief series of cases
Authors: Reis Jorge , Carmo Francisca , Soares Inês , Salvado Catarina , Fidalgo Mariana 
Published: February 2025

Background: Pseudomonas mendocina is a rare cause of disease in humans with few cases described, but known to cause severe infections, mainly endocarditis and bacteraemia. Case description: An 86-year-old Caucasian male, with several vascular risk factors (type 2 diabetes, hypertension, dyslipidaemia, coronary heart disease and heart failure), who presented long-standing lower limb phlyctens for which he was being treated, developed lower limb cellulitis. When observed in the Emergency Department, he was septic and was admitted for treatment and surveillance. Blood cultures were positive for P. mendocina. He was treated with antibiotics and recovered, and was discharged home. Conclusion: Damage to the skin barrier as in cellulitis provides a point of entry for P. mendocina, a microorganism that lives in soil and water. The source of contamination is rarely identified, but immunocompromised people present a higher risk of infection and severe disease. The antibiotic susceptibility profile is different from the more common Pseudomonas aeruginosa, with fewer known resistances. Albeit rare, this is thought to be an underreported infection that clinicians should be aware of.
Effect of power training on physical functional performance of patients with Parkinson’s disease: A systematic review and meta-analysis of randomized controlled trials
Authors: de Almeida Samuel Brito , Tavares Sobreira Emmanuelle Silva , de Lucena Alves Charles Phillipe , Lima Danielle Pessoa , de Carvalho Bonfadini Janine , Sobreira-Neto Manoel Alves , Freitas Thiago Holanda , do Nascimento Simony Lira , Braga-Neto Pedro 
Published: February 2025

Introduction
Parkinson’s disease (PD) is becoming more prevalent, highlighting the urgency of developing treatments to minimize its effects on muscular strength and physical function. Power training (PT) is a potential approach that may improve endurance and muscular power, essential for maintaining functional ability in PD.

Objective
To compare the effect of PT versus control or other physical activity (PA) interventions on physical functional performance (PFP) in PD patients.

Methods
We searched PubMed, MEDLINE, Embase, LILACS, PEDro, Cochrane Library, and Scopus. Inclusion criteria were randomized controlled trials comparing PT to a control group or another PA intervention in PD patients. PFP was the primary outcome. Pooled effect estimates were calculated from baseline to endpoint scores.

Results
From 21,558 results, four studies were included in the meta-analysis due to their moderate to high methodological quality. PT showed no significant effect on PFP outcomes compared to control groups (TUG: ES, −0.281; 95% CI, −0.693 to 0.130; P = 0.180; I2:0%; PWS: ES, 0.748; 95% CI, −0.768 to 2.265; P = 0.333; I2:88%; FWS: ES, 0.420; 95% CI, −0.950 to 1.791; P = 0.548; I2:83%; SLS: ES, 0.161; 95% CI, −0.332 to 0.655; P = 0.521; I2:0%). No differences were found between PT and alternative interventions (TUG: ES, 0.132; 95% CI, −0.394 to 0.657; P = 0.623; I2:0%; BBA: ES, 0.057; 95% CI, −0.430 to 0.544; P = 0.820; I2:0%).

Conclusion
PT did not improve PFP compared to control or alternative interventions. More studies are needed to explore PT effects (e.g., higher volume, intensity, and combined types) in PD patients.
Mapping the future: The current landscape and future directions of evidence-based practice in Saudi radiology departments
Authors: Alsharif Walaa , Alrehily Faisal , Alhazmi Fahad H. , Greeballah Awadia , Qurashi Abdulaziz A. , Aldahery Shrooq , Alahmadi Adnan , Alsaedi Amirah , Alshoabi Sultan , Alshamrani Khalid M. , Omer Awatif M. , Aljuhani Raghad 
Published: February 2025

Purpose
To examine the current application of Evidence-Based Practice (EBP) among radiology professionals, including radiologists and radiographers, in Saudi Arabia and to identify challenges in order to propose suitable future improvement strategies if it is required.

Method
A mixed-method design was used in this study. A survey consisting of 23 questions addressing research activities and EBP within radiology departments was sent to radiology personnel. The sample size of the quantitative phase of the study was determined using a formula specific for an infinite or unknown population. The formula used was n = P(1-P)Z2/d2, which resulted in a required sample size of 384 participants. A total of 345 participants; however, 45 did not fully complete the questionnaire and were therefore excluded. The data were analyzed using SPSS version 27. Inferential statistics, including non-parametric tests such as the Mann-Whitney U Test and the Kruskal-Wallis Test, were used to assess the influence of demographic factors on perceptions and challenges related to the adoption of evidence-based practice (EBP) in research within Saudi Arabia. Additionally, 20 semi-structured interviews were conducted with radiology personnel across the country. The sampling technique for the qualitative phase of the study was guided by the study’s objectives and the unique characteristics of the research group. The participants were purposively sampled in order to include radiologists and radiographers who work in different types of hospitals (public, semi-public, private) in Saudi Arabia. Responses from the interviews were coded, and key themes were identified following Miles and Huberman’s framework.

Results
The findings revealed a positive attitude towards research and EBP among Saudi radiology personnel. Over half of the participants (74.3%) strongly agreed that they understood and were familiar with EBP. They also felt confident in their ability to conduct scientific research in radiology (Mean = 4.27) and believed that they should actively initiate projects (Mean = 4.10). Radiologists reported a higher level of agreement compared to radiographers regarding their familiarity with EBP and their ability to critically evaluate the quality of research (P-value = <0.05). However, participants indicated lower level of agreement about their ability to develop their current practice based on EBP and engage in discussions with colleagues about research evidence. Key challenges identified include a lack of training, insufficient support and limited autonomy, which may hinder EBP implementation.

Conclusion
This study underscores the need for comprehensive education, ongoing training and a supportive organisational culture to enhance EBP adaption.
Armed violent conflict and healthcare-seeking behavior for maternal and child health in sub-Saharan Africa: A systematic review
Authors: Adeyanju Gbadebo Collins , Schrage Pia , Jalo Rabiu Ibrahim , Abreu Liliana , Schaub Max 
Published: February 2025

Background
Over 630 million women and children worldwide have been displaced by conflict or live dangerously close to conflict zones. While the adverse effects of physical destruction on healthcare delivery are relatively well understood, the effects on healthcare-seeking behavior remain underexplored, particularly in sub-Saharan Africa. This study aims to better understand the interconnections and knowledge gaps between exposure to armed violent conflicts and healthcare-seeking behaviors for maternal and child health in sub-Saharan Africa.

Methods
Five key electronic databases (PubMed, Scopus, Web of Science, PsycNET, and African Journals Online) were searched for peer-reviewed publications between 2000 and 2022. The review was designed according to PRISMA-P statement and the protocol was registered with PROSPERO database. The methodological quality and risks of bias were appraised using GRADE. A data extraction instrument was modelled along the Cochrane Handbook for Systematic Reviews and the Centre for Reviews and Dissemination of Systematic Reviews.

Result
The search results yielded 1,148 publications. Only twenty-one studies met the eligibility criteria, reporting healthcare-seeking behaviors for maternal and child health. Of the twenty-one studies, seventeen (81.0%) reported maternal health behaviors such as antenatal care, skilled birth attendance, postnatal care services, and family planning. Nine studies (42.8%) observed behaviors for child health such as vaccination uptake, case management for pneumonia, diarrhea, malnutrition, and cough. While conflict exposure is generally associated with less favorable healthcare-seeking behaviors, some of the studies found improved health outcomes. Marital status, male partner attitudes, education, income and poverty levels were associated with healthcare-seeking behavior.

Conclusion
There is a need for multifaceted interventions to mitigate the impact of armed violent conflict on healthcare-seeking behavior, given its overall negative effects on child and maternal healthcare utilization. While armed violent conflict disproportionately affects children’s health compared to maternal health, it is noteworthy that exposure to such conflicts may inadvertently also lead to positive outcomes.

Prospero registration number
CRD42023484004.
High mortality rates and long-term complications in children with infectious brainstem encephalitis: A study of sixteen cases
Authors: Zhou Yuanyuan , Zhu Yi , Cao Lingfeng , Shi Yingyan , Shen Jun 
Published: February 2025

Objective
Brainstem encephalitis (BE) can cause sudden death in children. Fewer studies have been conducted on the incidence, clinical manifestations, pathogens and post-infectious sequelae of pediatric infectious BE.

Methods
Pediatric patients diagnosed with BE in our Medical Center from 01 January 2015 to 31 July 2024 were retrospectively reviewed. The clinical data of these children were obtained from the hospital’s medical database on 15 August 2024. The number of outpatient and inpatient patients at our Medical Center during that period were provided by the hospital data center. Data analysis was conducted using Excel 2019.

Results
A total of twenty-eight cases were diagnosed with BE in our National Children′s Medical Center over the past decade. Among them, 57.1% (16/28) cases were diagnosed with infectious BE. The incidence of infectious BE was estimated to be 16 cases per 30 million outpatient visits and 13 cases per 500,000 hospitalized patients. Fever, consciousness disorders and seizures were observed in 75.0% (12/16), 68.8% (11/16) and 62.5% (10/16) of the cases, respectively. Among them, 31.3% (5/16) cases were diagnosed as human enterovirus infections, 12.5% (2/16) cases were confirmed to be influenza B virus infections, while one case each was diagnosed with herpes simplex virus 1 and human herpesvirus 6 infection. The mortality rate during hospitalization was 12.5% (2/16). Among the surviving patients, 50.0% (7/14) of them had follow-up records, 85.7% (6/7) of the survivors suffered from sequelae such as motor disorders.

Conclusion
Fever, consciousness disorders and seizures were the major clinical manifestations in patients with infectious BE visited our Medical Center. These rare cases exhibited a notably high mortality rate and a significant frequency of long-term complications.
Final Topology for Preference Spaces
Authors: Schenone Pablo 
Published: February 2025

Abstract
We say a model is continuous in utilities (resp., preferences) if small perturbations of utility functions (resp., preferences) generate small changes in the model’s outcomes. While similar, these two questions are different. They are only equivalent when the following two sets are isomorphic: the set of continuous mappings from preferences to the model’s outcomes, and the set of continuous mappings from utilities to the model’s outcomes. In this paper, we study the topology for preference spaces defined by such an isomorphism. This study is practically significant, as continuity analysis is predominantly conducted through utility functions, rather than the underlying preference space. Our findings enable researchers to extrapolate continuity in utility as indicative of continuity in underlying preferences.
Application of GNSS-levelling for updating the base vertical network
Authors: Borowski Łukasz , Banasik Piotr , Maciuk Kamil 
Published: February 2025

Abstract
This study explores the potential of GNSS-levelling to complement geometric levelling in the state levelling network, particularly outside the main lines. The Polish state levelling network plans to reduce the number of points from 40,000 to 16,000 during upcoming updates. GNSS-levelling is considered a cost-effective solution for filling gaps in the network, especially in rural areas. The experiment, commissioned by the Polish Head Office of Geodesy and Cartography, applied Polish geometric levelling accuracy criteria and tested them against GNSS-levelling. The goal was to develop a technique that an average surveying company could apply. The results showed that the initial hypothesis of GNSS-levelling’s suitability was not fully supported, primarily due to inconsistent vector repeatability. Accuracy could be improved by increasing the number of observation sessions or using specialized GNSS software while still maintaining cost-effectiveness. The experiment was conducted in an area where the state quasi-geoid model fits the levelling network with an accuracy of ±1 cm. Furthermore, the single vector solution (SVS) outperformed the each-to-each vector strategy (NET) in aligning with this network. Although challenges remain, GNSS-levelling demonstrates the potential and after refinement of techniques requirements, it is possible to obtain the main goal.
Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
Authors: Gu XiaoPeng , Zhang SongOu , Ma WeiHu 
Published: February 2025

Abstract

Background
It is unclear how the estimated glucose disposal rate (eGDR) index relates to osteoarthritis (OA). The goal of this research is to explore the possible link between the eGDR index and the likelihood of OA development.

Methods
The study encompassed 9,051 individuals from the National Health and Nutrition Examination Survey (2011–2018). Participants were divided into quartiles according to their eGDR, calculated with the equation: eGDR (mg/kg/min) = 21.158 − (0.09 × waist circumference) − (3.407 × hypertension) − (0.551 × glycosylated hemoglobin). We assessed the independent correlation between the eGDR metric and the incidence of OA through weighted multivariate regression, stratified analysis, and threshold effect evaluation.

Results
The study encompassed 9,051 participants, who had an average eGDR of 7.09. Participants with OA had lower eGDR levels compared to those without OA (6.27 ± 0.09 vs 7.31 ± 0.06, P < 0.001). The odds ratios (ORs) for OA associated with the eGDR index in the logistic regression models were 0.87 (95% confidence interval [CI]: 0.84, 0.89) in the unadjusted model I and 0.87 (95% CI: 0.84, 0.91) in model II (adjusted for all covariates). Higher eGDR index was associated with a reduced risk of OA when compared to the lowest quartile (Q1). A restricted cubic spline analysis indicated a linear negative relationship between eGDR and OA risk.

Conclusion
An increased eGDR index is inversely related to the risk of OA. The eGDR may serve as a valuable biomarker for the detection of OA and offers a new perspective for the assessment and management of the condition.
Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
Authors: Song Shengyou , Tai Lunwei , Zhou Lei , Jiang Junling , Zhao Junfeng 
Published: February 2025

Abstract

Objective
To investigate how lathyrol affects aggressive behaviors and related proteins of the androgen receptor (AR) 786-O cells.

Methods
786-O cells were cultured in vitro and divided into these groups at random: the dimethylsulfoxide (DMSO) control group (A group), negative control group (B group), and experimental group (C group). Cells in A group were grown in DMSO working medium (contained RPMI 1640 medium and 1% DMSO), B group cells were cultured in nilutamide working medium (contained DMSO working medium and 325 μg/mL nilutamide), while those in C group were cultured in lathyrol working medium (contained DMSO working medium and 300 μg/mL lathyrol). Cell proliferation was measured via CCK-8 assays, and cell apoptosis was examined through terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining. Scratch tests and Transwell invasion tests were used to evaluate cell movement and penetration. The expression information about p-AR, AR, p-Akt, ki67, caspase3, cleaved-caspase3, Bcl-2, Bax, caspase9, cleaved-caspase9, and GAPDH proteins was investigated through western blotting. Immunocytochemistry was used to identify the 786-O cells’ secretion level of matrix metalloproteinase 2 (MMP2), MMP9, and prostate-specific antigen (PSA) proteins.

Results
The negative control and experimental groups’ cells exhibited reduced proliferation, migration, and invasion and increased apoptosis after 24 h treatment. Furthermore, these two group cells exhibited a notable reduction in the status of Ki67, Bcl-2, MMP2, MMP9, and p-Akt (P < 0.05) and significantly increased the expressions of AR, p-AR, Bax, cleaved-caspase3, and cleaved-caspase9 (P < 0.05). There was no statistical distance in PSA, caspase3, and caspase9 expressions among the three groups (P > 0.05).

Conclusion

In vitro, lathyrol and nilutamide exert notable anticancer effects by effectively suppressing the proliferation, migration, and invasion of 786-O cells while also inducing apoptosis.
Rationalités correctives et intelligence artificielle assistée : les doubles contraintes des humanités numériques
Authors: Basso Fossali Pierluigi 
Published: February 2025

Résumé
Cet article explore la complexité de l’interaction entre l’Intelligence Artificielle (IA) et les rationalités humaines, en mettant l’accent sur les défis des humanités numériques. À travers une étude exploratoire, on articule deux perspectives : d’une part, la critique de l’idée que l’IA pourrait imiter ou reproduire fidèlement les rationalités humaines, et d’autre part, l’examen des limites et des possibilités de l’intelligence artificielle en tant que système autonome. L’analyse s’appuie sur des interactions prolongées avec ChatGPT, visant à tester les capacités de l’IA dans des contextes pédagogiques et épistémiques. L’article propose une reconceptualisation des relations entre jeux, calculs et mondes possibles, en soulignant les implications pour des sémiosphères différentes (culturelle/artificielle) et les standards de rationalité. Finalement, l’article vise à problématiser les rôles potentiels de l’IA en tant que catalyseur d’énonciation, médiateur dans une cognition distribuée, et agent participant à une intelligence collective, tout en soulignant les limites intrinsèques des capacités réflexives et cognitives de l’IA.
Hypereides: Verteidigungsrede für Euxenippos gegen Polyeuktos wegen Landesverrats– Zur Frage der Datierung
Authors: Horváth László 
Published: February 2025

AbstractHypereides' In defence of Euxenippus against Polyeuctus upon his indictment for treason was dated by its first editor Churchill Babington to the year 334 BC, while the second editor, Domenico Comparetti, places the possible date of composition almost ten years later, to the period between 330 and 324 BC. According to Comparetti, the orator could only have quoted the expression ‘Molossia is mine’ from the letter of Alexander's mother Olympias to the Athenian people at the time when Olympias was already ruler of the territory in question, i.e. after the death of her brother in 331 BC. This date has been accepted as the factual date of composition for over 150 years, so editors have adapted several emendations and alternative interpretations to this view. This study argues that the speech should be dated to 334/333 BC according to the surviving, clearly interpretable text and that any emendations are therefore superfluous – Churchill Babington was right.
Returning to Her Spiritual Roots: Sandra Cisneros and the Weaving of Buddhist Motifs in Caramelo
Authors: Guittar Michelle 
Published: February 2025

Abstract
Sandra Cisneros, one of the most prominent Mexican American authors alive today, began integrating Buddhist themes in her work as early as 1994. This article explores how Cisneros’s Buddhist practice has strengthened over time, with evidence taken from her poetry, archival documents, and interviews. The analysis then turns to a close reading of her 2002 novel, Caramelo, to identify how she incorporates Buddhist themes into the text. Using the motifs of recuerdos/memories, dust/dirt, and the woven rebozo scarf, Cisneros uses the Buddhist concepts of impermanence and interdependence to tell the story of a granddaughter’s growing wisdom and compassion towards her Mexican American family.