bluuebunny/crossref_metadata_2025_split huggingface dataset:
A necessary and sufficient condition for the existence of global solutions to reaction-diffusion equations on bounded domains
Authors: Chung Soon-Yeong , Hwang Jaeho 
Published: January 2024

AbstractThe purpose of this paper is to give a necessary and sufficient condition for the existence and non-existence of global solutions of the following semilinear parabolic equations $$ u_{t}=\Delta u+\psi (t)f(u),\quad \text{in }\Omega \times (0,\infty ), $$

u
t

=
Δ
u
+
ψ
(
t
)
f
(
u
)
,

in
Ω
×
(
0
,
∞
)
,
under the mixed boundary condition on a bounded domain Ω. In fact, this has remained an open problem for a few decades, even for the case $f(u)=u^{p}$
f
(
u
)
=

u
p

. As a matter of fact, we prove: $$ \begin{aligned} & \text{there is no global solution for any initial data if and only if } \\ & \int _{0}^{\infty}\psi (t) \frac{f (\lVert S(t)u_{0}\rVert _{\infty} )}{\lVert S(t)u_{0}\rVert _{\infty}}\,dt= \infty \\ &\text{for every nonnegative nontrivial initial data } u_{0}\in C_{0}( \Omega ). \end{aligned} $$

there is no global solution for any initial data if and only if

∫
0
∞

ψ
(
t
)

f
(

∥
S
(
t
)

u
0

∥

∞

)

∥
S
(
t
)

u
0

∥

∞

d
t
=
∞

for every nonnegative nontrivial initial data

u
0

∈

C
0

(
Ω
)
.

Here, $(S(t))_{t\geq 0}$

(
S
(
t
)
)

t
≥
0

is the heat semigroup with the mixed boundary condition.
Pre-hatch thermal manipulation of embryos and post-hatch baicalein supplementation mitigated heat stress in broiler chickens
Authors: Al Amaz Sadid , Chaudhary Ajay , Mahato Prem Lal , Jha Rajesh , Mishra Birendra 
Published: January 2024

Abstract
Background
High environmental temperatures induce heat stress in broiler chickens, affecting their health and production performance. Several dietary, managerial, and genetics strategies have been tested with some success in mitigating heat stress (HS) in broilers. Developing novel HS mitigation strategies for sustaining broiler production is critically needed. This study investigated the effects of pre-hatch thermal manipulation (TM) and post-hatch baicalein supplementation on growth performance and health parameters in heat-stressed broilers.

Results
Six hundred fertile Cobb 500 eggs were incubated for 21 d. After candling on embryonic day (ED) 10, 238 eggs were thermally manipulated at 38.5 °C with 55% relative humidity (RH) from ED 12 to 18, then transferred to the hatcher (ED 19 to 21, standard temperature) and 236 eggs were incubated at a controlled temperature (37.5 °C) till hatch. After hatch, 180-day-old chicks from both groups were raised in 36 pens (n = 10 birds/pen, 6 replicates per treatment). The treatments were: 1) Control, 2) TM, 3) control heat stress (CHS), 4) thermal manipulation heat stress (TMHS), 5) control heat stress supplement (CHSS), and 6) thermal manipulation heat stress supplement (TMHSS). All birds were raised under the standard environment for 21 d, followed by chronic heat stress from d 22 to 35 (32–33 °C for 8 h) in the CHS, TMHS, CHSS, and TMHSS groups. A thermoneutral (22–24 °C) environment was maintained in the Control and TM groups. RH was constant (50% ± 5%) throughout the trial. All the data were analyzed using one-way ANOVA in R and GraphPad software at P < 0.05 and are presented as mean ± SEM. Heat stress significantly decreased (P < 0.05) the final body weight and ADG in CHS and TMHS groups compared to the other groups. Embryonic TM significantly increased (P < 0.05) the expression of heat shock protein-related genes (HSP70, HSP90, and HSPH1) and antioxidant-related genes (GPX1 and TXN). TMHS birds showed a significant increment (P < 0.05) in total cecal volatile fatty acid (VFA) concentration compared to the CHS birds. The cecal microbial analysis showed significant enrichment (P < 0.05) in alpha and beta diversity and Coprococcus in the TMHSS group.

Conclusions
Pre-hatch TM and post-hatch baicalein supplementation in heat-stressed birds mitigate the detrimental effects of heat stress on chickens' growth performance, upregulate favorable gene expression, increase VFA production, and promote gut health by increasing beneficial microbial communities.
Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids
Authors: Chai Jianmin , Zhuang Yimin , Cui Kai , Bi Yanliang , Zhang Naifeng 
Published: January 2024

Abstract
Background
The gut microbiome of domestic animals carries antibiotic resistance genes (ARGs) which can be transmitted to the environment and humans, resulting in challenges of antibiotic resistance. Although it has been reported that the rumen microbiome of ruminants may be a reservoir of ARGs, the factors affecting the temporal dynamics of the rumen resistome are still unclear. Here, we collected rumen content samples of goats at 1, 7, 14, 28, 42, 56, 70, and 84 days of age, analyzed their microbiome and resistome profiles using metagenomics, and assessed the temporal dynamics of the rumen resistome in goats at the early stage of life under a conventional feeding system.

Results
In our results, the rumen resistome of goat kids contained ARGs to 41 classes, and the richness of ARGs decreased with age. Four antibiotic compound types of ARGs, including drugs, biocides, metals, and multi-compounds, were found during milk feeding, while only drug types of ARGs were observed after supplementation with starter feed. The specific ARGs for each age and their temporal dynamics were characterized, and the network inference model revealed that the interactions among ARGs were related to age. A strong correlation between the profiles of rumen resistome and microbiome was found using Procrustes analysis. Ruminal Escherichia coli within Proteobacteria phylum was the main carrier of ARGs in goats consuming colostrum, while Prevotella ruminicola and Fibrobacter succinogenes associated with cellulose degradation were the carriers of ARGs after starter supplementation. Milk consumption was likely a source of rumen ARGs, and the changes in the rumen resistome with age were correlated with the microbiome modulation by starter supplementation.

Conclusions
Our data revealed that the temporal dynamics of the rumen resistome are associated with the microbiome, and the reservoir of ARGs in the rumen during early life is likely related to age and diet. It may be a feasible strategy to reduce the rumen and its downstream dissemination of ARGs in ruminants through early-life dietary intervention.
Reduced efficacy of single-dose albendazole against Ascaris lumbricoides, and Trichuris trichiura, and high reinfection rate after cure among school children in southern Ethiopia: a prospective cohort study
Authors: Gebreyesus Tigist Dires , Makonnen Eyasu , Tadele Tafesse , Mekete Kalkidan , Gashaw Habtamu , Gerba Heran , Aklillu Eleni 
Published: January 2024

Abstract
Background
Mass drug administration (MDA) program of albendazole to at-risk populations as preventive chemotherapy is the core public health intervention to control soil-transmitted helminths (STHs). Achieving this goal relies on drug effectiveness in reducing the parasite reservoirs in the community and preventing reinfection. We assessed the efficacy of albendazole against STH parasite infection and reinfection status after cure.

Methods
A total of 984 schoolchildren infected with at least one type of STH parasite (hookworm, Ascaris lumbricoides, Trichuris trichiura) in southern Ethiopia were enrolled and received albendazole and praziquantel in MDA campaign conducted from January to March 2019. Stool exams at week-4 and at week-8 of post-MDA were done using Kato Katz technique. The primary outcome was efficacy assessed by cure rate (CR) and fecal egg reduction rates (ERRs) at four weeks of post-MDA. The secondary outcome was reinfection status defined as parasite egg positivity at eight weeks among those who were cured at 4 weeks of post-MDA. Group comparisons in CR and related factors were assessed with chi-square or Fisher’s exact tests. Predictors of CR were examined through univariate and multivariate regression analyses.

Results
The overall CR and ERR for hookworm infection were 97.2% (95% CI 94.6–99.4) and 97.02%, respectively. The overall CR and ERR for A. lumbricoides were 71.5% (95% CI 68.3–74.6) and 84.5% respectively. The overall CR and ERR and for T. trichiura were 49.5% (95% CI 44.8–54.2) and 68.3%, respectively. The CR among moderate T. trichiura infection intensity was 28.6%. Among children cured of hookworm, A. lumbricoides and T. trichiura at week 4 post-MDA, 4.6%, 18.3% and 52.4% became reinfected at week-8 post-MDA, respectively. Significantly lower CR (36.6%) and higher reinfection after cure (60.6%) among A. lumbricoides and T. trichiura coinfected children than A. lumbricoides only (CR = 69.6%, reinfection rate = 15.1%) or T. trichiura only infected children (CR = 55.6%, reinfection rate = 47.1%) was observed. Pre-treatment coinfection with ≥ two types of STH parasites was significantly associated with re-infection after cure.

Conclusion
Albendazole MDA is efficacious against hookworm but has reduced efficacy against A. lumbricoides and is not effective against T. trichiura. The low drug efficacy and high reinfection rate after cure underscore the need for alternative treatment and integration of other preventive measures to achieve the target of eliminating STHs as a public health problem by 2030.

Graphical Abstract
Spontaneous splenic rupture associated with scrub typhus: a case report
Authors: Hwang Hong Pil , Kim Kyoung Min , Han Hyojin , Hwang Jeong-Hwan 
Published: January 2024

Abstract
Background
Scrub typhus, an acute febrile disease with mild to severe, life-threatening manifestations, potentially presents with a variety of complications, including pneumonia, acute respiratory distress syndrome, cardiac arrhythmias (such as atrial fibrillation), myocarditis, shock, peptic ulcer, gastrointestinal bleeding, meningitis, encephalitis, and renal failure. Of the various complications associated with scrub typhus, splenic rupture has rarely been reported, and its mechanisms are unknown. This study reports a case of scrub typhus-related spontaneous splenic rupture and identifies possible mechanisms through the gross and histopathologic findings.

Case presentation
A 78-year-old man presented to our emergency room with a 5-day history of fever and skin rash. On physical examination, eschar was observed on the left upper abdominal quadrant. The abdomen was not tender, and there was no history of trauma. The Orientia tsutsugamushi antibody titer using the indirect immunofluorescent antibody test was 1:640. On Day 6 of hospitalization, he complained of sudden-onset left upper abdominal quadrant pain and showed mental changes. His vital signs were a blood pressure of 70/40 mmHg, a heart rate pf 140 beats per min, and a respiratory rate of 20 breaths per min, with a temperature of 36.8 °C. There were no signs of gastrointestinal bleeding, such as hematemesis, melena, or hematochezia. Grey Turner's sign was suspected during an abdominal examination. Portable ultrasonography showed retroperitoneal bleeding, so an emergency exploratory laparotomy was performed, leading to a diagnosis of hemoperitoneum due to splenic rupture and a splenectomy. The patient had been taking oral doxycycline (100 mg twice daily) for 6 days; after surgery, this was discontinued, and intravenous azithromycin (500 mg daily) was administered. No arrhythmia associated with azithromycin was observed. However, renal failure with hemodialysis, persistent hyperbilirubinemia, and multiorgan failure occurred. The patient did not recover and died on the fifty-sixth day of hospitalization.

Conclusions
Clinicians should consider the possibility of splenic rupture in patients with scrub typhus who display sudden-onset abdominal pain and unstable vital signs. In addition, splenic capsular rupture and extra-capsular hemorrhage are thought to be caused by splenomegaly and capsular distention resulting from red blood cell congestion in the red pulp destroying the splenic sinus.

Graphical abstract
Relationship of self-reported pica and avoidant restrictive food intake disorder symptomology with dimensions of impulsivity, perceived stress among Pakistani University students
Authors: Haqqi Sara Aleem , Irfan Siddrah 
Published: January 2024

Abstract
Introduction
Pica and avoidant/restrictive food intake disorder are two of the three new eating and feeding disorders introduced in the DSM-5, this inclusion has drawn attention to the immediate need for research into their prevalence, diagnostic assessment, underlying risk factors and optimal treatment. There are very few studies available that explored the predictors or causes of these eating disorders specifically in Pakistani context.

Objectives
The objectives of the current study include (a) to estimate the presence of pica and avoidant/restrictive food intake disorder symptomology among young adults in Pakistan, (b) to examine the relationship between dimensions of impulsivity, stress and presence of pica and avoidant/restrictive food intake disorder, (c) to explore the mediation role of stress.

Methods
The sample consisted of 660 young adults with age range 18–25 years, recruited through convenient sampling. The respondents were provided with a questionnaire comprising of an informed consent, a demographic information sheet and self-report measures including PARDI-AR-Q to assess symptomology of pica and avoidant/restrictive food intake disorder, UPPS-P Impulsive Behaviour Scale to assess dimensions of impulsivity and Perceived Stress Scale to measure perceived stress.

Results
The findings show that 28 participants (4.2%) reported Pica symptomology, of which eleven participants indicated that they currently consume more than one non-food item. 19 respondents (2.8%) reported avoidant/restrictive food intake disorder symptomology. 13 respondents reported varying degrees of all three symptom clusters namely sensory based food avoidance, lack of interest in food, and fear of negative consequences of eating. Additionally, each of the dimensions of impulsivity was found to be positively correlated to the presence of pica and avoidant/restrictive food intake disorder. Perceived stress was identified as a mediating factor between each of the dimensions of impulsivity and presence of pica and avoidant/restrictive food intake disorder.

Conclusion
Although current study focused on a particular age range, it has drawn attention to the necessity of screening and investigating other strata of Pakistani population for pica and avoidant/restrictive food intake disorder. The clinical utility of the present research resided in the identification of factors associated with pica and avoidant/restrictive food intake disorder, an information which can be used to tailor psychological interventions, modify existing ones, and inform the future research on evidence-based treatment.
Generalized Estimating Equations Boosting (GEEB) machine for correlated data
Authors: Wang Yuan-Wey , Yang Hsin-Chou , Chen Yi-Hau , Guo Chao-Yu 
Published: January 2024

AbstractRapid development in data science enables machine learning and artificial intelligence to be the most popular research tools across various disciplines. While numerous articles have shown decent predictive ability, little research has examined the impact of complex correlated data. We aim to develop a more accurate model under repeated measures or hierarchical data structures. Therefore, this study proposes a novel algorithm, the Generalized Estimating Equations Boosting (GEEB) machine, to integrate the gradient boosting technique into the benchmark statistical approach that deals with the correlated data, the generalized Estimating Equations (GEE). Unlike the previous gradient boosting utilizing all input features, we randomly select some input features when building the model to reduce predictive errors. The simulation study evaluates the predictive performance of the GEEB, GEE, eXtreme Gradient Boosting (XGBoost), and Support Vector Machine (SVM) across several hierarchical structures with different sample sizes. Results suggest that the new strategy GEEB outperforms the GEE and demonstrates superior predictive accuracy than the SVM and XGBoost in most situations. An application to a real-world dataset, the Forest Fire Data, also revealed that the GEEB reduced mean squared errors by 4.5% to 25% compared to GEE, XGBoost, and SVM. This research also provides a freely available R function that could implement the GEEB machine effortlessly for longitudinal or hierarchical data.
Persisting in tough times across Hong Kong, mainland China, and the Philippines: grit, achievement goal orientation, and science engagement
Authors: Datu Jesus Alfonso D. , Chiu Ming Ming , Mateo Nino Jose , Yang Lan 
Published: January 2024

Abstract
Background
Past studies of grit's educational benefits, such as science engagement, showed mixed results across cultures. So, we elaborated the prior model of grit (perseverance of effort, consistency of interest) with adaptability to situations (forming a triarchic model of grit TMG), and tested TMG's relation to subsequent science engagement.

Methods
In this study, 1,972 high school students in Hong Kong, mainland China, and the Philippines completed surveys twice (about 6 months apart). We analysed these data with multilevel structural equation modelling.

Results
Results showed that country income (GDP per capita) negatively predicted science engagement, while schools with the highest ability students had higher science engagement. Conscientiousness and overall grit positively predicted science engagement at both time periods. Consistency of interest negatively predicted science engagement.

Conclusions
This research demonstrates the potential academic benefits of grit in non-Western societies. Promoting grit may serve as a pathway towards greater students’ engagement in science.
Development of a fabric classification system using drapability and tactile characteristics
Authors: Lee Somin , Han Yoojung , Yun Changsang 
Published: January 2024

AbstractWhen producing clothing using virtual fitting technology or purchasing textile and clothing products online, it is challenging to make judgments or communicate information about sensory characteristics, such as drapability and tactile sensations, as there are no clear objective indicators for these factors. Therefore, the study aims to develop a classification system for the sensory properties of fabrics using drapability and tactile characteristics as quantitative indicators. The developed system was verified through subjective evaluations by an expert group, and it was found to be meaningful in reflecting classification levels in practice. The drapability and tactile sensation (softness; TS7) of the fabric were classified using fuzzy c-means cluster analysis, and the results were confirmed through a subjective evaluation by experts. The classification system was then used to predict the classification group, constituted by drapability and tactile characteristics, from mechanical properties using an artificial neural network. The network was trained on 534 fabric samples for drapability and tactile sensation (softness), and it correctly predicted 202 samples out of 243 validation data, with a forecasting accuracy of 83.5%. The developed classification system enables predictions and judgments about subjective characteristics like fabric drapability and tactile sensation based on the mechanical property values of various samples.
“Frisbee on football field”: the intergenerational conflict between two sports at grassroots level in China
Authors: Liu Songjie , Jin Ye , Chen Yutao 
Published: January 2024

AbstractUltimate frisbee has gained great attention and enjoyed explosive growth in China from 2019 to 2022 (especially in 2022), but has also aroused heated controversies in cyberspace, typically in the football community. This paper explores the forms and underlying reasons for conflicts between the two sports. Through field observation, in-depth interviews, and a survey of amateur participants in both frisbee and football, the paper finds that conflicts between the two sports, which arise from ultimate frisbee’s quest for legitimacy, are exaggerated as a result of the mediatization of sports. The study further revealed that Frisbee, as an alternative sport, exhibits notable cultural distinctions from football, a traditional sport. This divergence in sports culture mirrors the generational gap. Consequently, the conflict between the two sports is more of an intergenerational conflict within the realm of sports culture, reflecting the overall transformation of Chinese society.
Complement System Deficiencies in Elite Athletes
Authors: Vítek Libor , Woronyczova Jana , Hanzikova Veronika , Posová Helena 
Published: January 2024

Abstract
Background
Although regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in elite athletes is associated with an increased susceptibility to infectious complications. Therefore, the objective of our study was to assess the routinely examined parameters of the complement system in elite athletes. The study was carried out in a cohort of elite athletes (n = 134) and healthy control subjects (n = 110). In all subjects, besides a routine laboratory check-up, serum concentrations of the C3 and C4 complement components, mannose-binding lectin (MBL), as well as activation of all three complement pathways were determined.

Results
Compared to healthy controls, lower C3 and C4 complement component concentrations were observed in elite athletes (0.96 ± 0.1 vs. 1.08 ± 0.2 mg/L, and 0.18 ± 0.1 vs. 0.25 ± 0.1 mg/L, respectively, p < 0.05); with much higher frequency rates of C3 and C4 deficiencies in athletes (31.3 vs. 14.5%, and 6 vs. 0%, p < 0.05). Simultaneously, athletes had much higher frequency rates of deficiencies of activation of classical and alternative complement pathways; while, deficiency of activation of the lectin pathway was similar in both cohorts.

Conclusions
We confirmed a high frequency of defects in the complement system in elite athletes. Lower concentrations of C3 and C4 complement components, with high frequencies of deficiencies of the classical and alternative complement activation pathways were the most prevalent disorder of the complement system in elite athletes. Further studies are needed to uncover the functional impacts of these observations upon the susceptibility to infectious diseases.