bluuebunny/crossref_metadata_2025_split huggingface dataset:
State Resident Handedness, Ideology, and Political Party Preference: U.S. Presidential Election Outcomes Over the Past 60 Years
Authors: McCann Stewart J. H. 
Published: January 2024

Pearson correlation, partial correlation, and multiple regression strategies determined the degree to which estimates of the level of left-handedness in each of the 48 contiguous American states related to citizen political ideology and to Democratic-Republican presidential popular vote over the past 60 years. Higher state levels of left-handedness were associated significantly with liberal ideology in each of the presidential election years from 1964 to 2016. Comparable ideology data were not available for 2020. Higher state levels of left-handedness also were associated with a greater degree of Democratic candidate popular vote support in each of the presidential election years from 1964 to 2020 except for 1976. The mean size of these 28 significant Pearson correlations involving the two political criteria was .62 ( SD = .12) with a range of .38–.80, indicating handedness alone could account for a mean of 40.1% ( SD = 14.9) of the variance in the two political preference variables. Corresponding multiple regressions showed that when state-level Big Five personality, White population percent, urbanization, and income variables were given the opportunity to enter the equations, handedness still emerged with a significant regression coefficient in 26 of the 28 equations. The two exceptions occurred for 1968 with either political preference criterion. It is speculated that such relations are grounded in hypothesized but poorly understood genetic links between handedness, personality, and political beliefs and attitudes, and, that a foundational genetic predisposition to left-handedness in a population may have much greater impact on correlates than overt levels of left-handedness.
Impact of pulmonary hypertension on short-term outcomes in patients undergoing surgical aortic valve replacement for severe aortic valve stenosis
Authors: Ivanov Borko , Krasivskyi Ihor , Förster Friedrich , Gaisendrees Christopher , Elderia Ahmed , Großmann Clara , Mihaylova Mariya , Djordjevic Ilija , Eghbalzadeh Kaveh , Sabashnikov Anton , Kuhn Elmar , Deppe Antje-Christin , Rahmanian Parwis Baradaran , Mader Navid , Gerfer Stephen , Wahlers Thorsten 
Published: January 2024

Objectives In patients with left heart disease and severe aortic stenosis (AS), pulmonary hypertension (PH) is a common comorbidity and predictor of poor prognosis. Untreated AS aggravates PH leading to an increased right ventricular afterload and, in line to right ventricular dysfunction. The surgical benefit of aortic valve replacement (AVR) in elderly patients with severe AS and PH could be limited due to the multiple comorbidities and poor outcomes. Therefore, we purposed to investigate the impact of PH on short-term outcomes in patients with moderate to severe AS who underwent surgical AVR in our heart center. Methods In this study we retrospectively analyzed a cohort of 99 patients with severe secondary post-capillary PH who underwent surgical AVR (AVR + PH group) at our heart center between 2010 and 2021 with a regard to perioperative outcomes. In order to investigate the impact of PH on short-term outcomes, the control group of 99 patients without pulmonary hypertension who underwent surgical AVR (AVR group) at our heart center with similar risk profile was accordingly analyzed regarding pre-, intra- and postoperative data. Results Atrial fibrillation occurred significantly more often ( p = .013) in patients who suffered from PH undergoing AVR. In addition, the risk for cardiac surgery (EUROSCORE II) was significantly higher ( p < .001) in the above-mentioned group. Likewise, cardiopulmonary bypass time ( p = .018), aortic cross-clamp time ( p = .008) and average operation time ( p = .009) were significantly longer in the AVR + PH group. Furthermore, the in-hospital survival rate was significantly higher ( p = .044) in the AVR group compared to the AVR + PH group. Moreover, the dialysis rate was significantly higher ( p < .001) postoperatively in patients who suffered PH compared to the patients without PH undergoing AVR. Conclusion In our study, patients with severe PH and severe symptomatic AS who underwent surgical aortic valve replacement showed adverse short-term outcomes compared to patients without PH.
The impact of cannabidiol placebo on responses to an acute stressor: A replication and proof of concept study
Authors: Zhekova Radostina M , Perry Robin N , Spinella Toni C , Dockrill Kayley , Stewart Sherry H , Barrett Sean P 
Published: January 2024

Background: Our group has previously reported that cannabidiol (CBD) expectancy alone blunts markers of stress, particularly during anticipation, but it is not clear the extent to which such findings were specific to the methods utilized. Aims: To examine CBD-related placebo effects on stress reactivity and anticipation and to validate a protocol to be used in a neuroimaging study. Methods: Forty-eight healthy adults (24 female) were randomly assigned to be informed that they ingested a CBD-containing oil or a CBD-free oil despite receiving the same oil (CBD-free). Following oil administration, participants engaged in a laboratory stressor and were then incorrectly informed that they would engage in a second more difficult task following a waiting period. Subjective state (sedation, energy, stress, anxiety) and heart rate were assessed at baseline, post-oil administration, immediately following the first stressor, and while anticipating the second stressor. Results: Subjective stress and anxiety were significantly elevated immediately following the stressor ( p-values < 0.001). CBD expectancy was associated with increased subjective sedation ( p < 0.01) and tended to be associated with blunted subjective stress ( p = 0.053). Post hoc within-condition pairwise compassions suggested a return to pre-stressor levels during the anticipation period in the CBD condition for subjective stress and anxiety ( p = 0.784, 0.845), but not the CBD-free condition ( p = 0.025, 0.045). Conclusion: Results replicate and extend previous findings that CBD expectancy alone can impact stress- and anxiety-relevant responses in the laboratory context.
Calcitonin gene-related peptide receptor antagonism reduces motion sickness indicators in mouse migraine models
Authors: Rahman Shafaqat M , Luebke Anne E 
Published: January 2024

Background Migraine and vestibular migraine are disorders associated with a heightened motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness. VM affects ∼3% of adults in the USA and affects three-fold more women than men. Triptans (selective serotonin receptor agonists) relieve migraine pain but lack efficacy for vertigo. Murine models of photophobia and allodynia have used injections of calcitonin gene-related peptide (CGRP) or other migraine triggers, such as sodium nitroprusside (SNP), to induce migraine sensitivities in mice to touch and light. Yet, there is limited research on whether these triggers affect motion-induced nausea in mice, and whether migraine blockers can reduce these migraine symptoms. We hypothesized that systemic delivery of CGRP or SNP will increase motion sickness susceptibility and motion-induced nausea in mouse models, and that migraine blockers can block these changes induced by systemically delivered CGRP or SNP. Methods We investigated two measures of motion sickness assessment [motion sickness index (MSI) scoring and motion-induced thermoregulation] after intraperitoneal injections of either CGRP or SNP in C57BL/6J mice. The drugs olcegepant, sumatriptan and rizatriptan were used to assess the efficacy of migraine blockers. Results MSI measures were confounded by CGRP’s effect on gastric distress. However, analysis of tail vasodilatations as a surrogate for motion-induced nausea was robust for both migraine triggers. Only olcegepant treatment rescued tail vasodilatations. Conclusions These preclinical findings support the use of small molecule CGRP receptor antagonists for the treatment of motion-induced nausea of migraine, and show that triptan therapeutics are ineffective against motion-induced nausea of migraine. Trial Registration: Not Applicable
The Effect of Antenatal Breast Milk Care Bundles on the Availability of Breast Milk in Preterms ≤32 Weeks: A Cohort Study
Authors: Wilson Krishna N. , Rahul Aswathy , Sujatha Radhika , Amma Sobhakumar Saraswathy , Sharma Anu 
Published: January 2024

Background Though early enteral nutrition with Mother’s own milk (MOM) is the norm in preterms, it is a difficult challenge to get it into the intensive care unit due to various medical and logistic issues. Awareness about this among pregnant ladies and their caregivers from the antenatal period may help to overcome some of these difficulties. Objective To compare the effect of the implementation of an antenatal breast milk care bundle on the availability of adequate breast milk on day 7 for preterm babies ≤ 32 weeks when compared to a postnatal breast milk care bundle alone. Methodology This prospective study was conducted among neonates ≤32 weeks born in Government Medical College, Thiruvananthapuram from January 2021 to May 2022. Antenatal bundles were implemented in the antenatal OPDs and wards. Postnatal bundles were implemented in the NICU and postnatal wards. The outcome was compared among babies of mothers who got both the care bundles and those who received only the postnatal care bundle. Results A total of 110 babies were included in the study. There was a 1.32 times increase in the adequacy of milk volume on day 7 (CI: 1.04–1.68), a significant increase in the proportion of mothers expressing within 24 hours, and babies getting discharged on exclusive MOM in those who received the antenatal BMC bundles. The risk for inadequate milk volume was high in those who have <2 ml of milk at 48 hours (RR: 1.67, CI:1.26–2.20]. Conclusion Antenatal breast milk care bundles can increase the availability of adequate MOM for preterm babies.
Operation STICK: A vascular access specialty program for the generalist emergency medicine clinician
Authors: Bahl Amit , Mielke Nicholas , DiLoreto Emily , Gibson S. Matthew 
Published: January 2024

Objective: Comprehensive education and training programs are urgently needed to improve vascular access outcomes in the emergency department (ED). This study aimed to demonstrate the success of a formalized vascular access program in developing competent ED clinicians in traditional and ultrasound-guided insertion methods. Methods: This was a retrospective observational study exploring the success of trainees in obtaining competency in peripheral vascular access at an academic suburban ED with 120,000 annual visits. Eligible participants included healthcare workers that enrolled in the Operation STICK vascular access program and perform vascular access procedures as an aspect of their clinical practice. Competency in vascular access included both traditional and ultrasound-guided (US) peripheral intravenous catheter (PIVC) insertions. Competency was defined as demonstration of successful insertion of one traditional and one US PIVC in compliance with checklist. The primary objective was competency. Secondary objectives included trainee time to competency, trainee number of line encounters, and changes in program competency achievements over time. Results: From October 15, 2021, to April 15, 2023, 141 clinicians participated in peripheral vascular access training via the Operation STICK model, which included 72 (51.1%) nurses, 52 (36.9%) ED technicians, and 17 (12.0%) healthcare personnel with other medical training. Clinicians overall reported an average of 5.6 years of experience inserting peripheral intravenous catheters (PIVCs) and 23 (16.3%) had experience with using ultrasound. About 122 (86.5%) clinicians successfully completed the program and demonstrated competency in traditional and ultrasound-guided techniques. Time to competency varied over time, with a median of 124 days in the early phase, 32.5 days middle phase, and 10.6 h over 9.5 days in the later phase of the program ( p < 0.001). Conclusions: Achieving competency in PIVC insertion necessitates a focused effort on refining and systematizing education and training approaches. Recognizing the inherent challenges present in ED settings, it is feasible to effectively and efficiently train emergency clinicians to be expert in both basic and advanced PIVC placement techniques through participation in a well-organized vascular access training program.
A new approach for reliability assessment of the smart microgrids using k-shortest path algorithms
Authors: Gholami Mohammadreza , Mohammadtaheri Meysam , Gholami Alireza 
Published: January 2024

The reliability of cyber-physical microgrids (MGs) is crucial in the development of smart grids. The reliability of MGs can be affected by cyber network failures, which have a significant impact on the physical components. Since MGs have interdependent cyber and physical elements, a smart MG can be viewed as a system of n dependent two-mode components. This paper proposes an approach to finding the k most likely configurations of the system. The method involves three phases. Firstly, the multi-mode model is obtained for physical components, considering the operation and topology of the cyber network. Then, the problem is transformed to finding the k most likely state of a system consisting of n independent multi-mode components. In the second phase, a transformation using new transformed metrics is applied. This results in the problem being converted to finding the k shortest path, which can be solved using efficient algorithms. Finally, the states are evaluated using a DC load flow, and reliability indices such as loss of load probability (LOLP) and expected energy not supplied (EENS) are calculated. Moreover, we have incorporated the dynamic thermal rating (DTR) system into our proposed model, addressing the safe enhancement of system component ratings. The results indicate that the most probable states of the system are related to the failure of distribution generators. The most severe events occur due to failure in the cyber network, and cyber network malfunction has a higher effect on EENS compared to LOLP. Additionally, we observe a significant enhancement in reliability indices when considering the DTR system over the static thermal rating (STR) system. This approach is efficient in reliability calculation using fewer system states.
The natural history of benign prostatic hyperplasia-related voiding symptoms following penile prosthesis implantation
Authors: Bole Raevti , Khooblall Prajit , Bajic Petar 
Published: January 2024

Background: There is a rising prevalence of benign prostatic hyperplasia (BPH)-related urinary symptoms along with erectile dysfunction in the aging male population. Therefore, assessment of lower urinary tract symptoms (LUTS) is advised before penile prosthesis surgery with some men requiring preoperative transurethral surgical management to reduce the risk of post-procedure complications. However, less is known about the natural history of men with uncomplicated LUTS who do not require surgical management for BPH before penile prosthesis. Objective: We sought to assess the natural history of BPH-related uncomplicated LUTS in men following penile prosthesis surgery. Design: Single institution retrospective review. Methods: Following institutional review board approval, we performed a retrospective review of all adult males with a preoperative diagnosis of LUTS undergoing penile prosthesis surgery at our institution from January 2017 to November 2022. The primary outcome was progression to transurethral surgery. Results: From 2017 to 2022, 211 patients with preexisting LUTS underwent penile prosthesis surgery and met all criteria for inclusion including no history of transurethral surgery. The median (interquartile range, IQR) AUA symptom score (AUA-SS) was 12 (12). Post-void residual was below 200 cc in 96.2% of patients preoperatively and 99.1% of patients after surgery. At a median (IQR) follow-up duration of 9 (23) months after surgery, 5.7% (12/211) of patients had progressed to bladder outlet surgery and 35.5% of patients endorsed LUTS bother with a median (IQR) AUA-SS of 14.5 (11.8). Conclusion: The majority of patients with uncomplicated LUTS did not require bladder outlet surgery following penile prosthesis implantation and could be managed with conservative or pharmacologic measures alone. Prostate gland size was significantly larger in patients who progressed to bladder outlet surgery. While the results are overall reassuring, further study is needed to identify specific factors associated with pursuing bladder outlet surgery in this small subset of patients.
Digital health and patient adherence: A qualitative study in older adults
Authors: Ferreira-Brito Filipa , Alves Sérgio , Guerreiro Tiago , Santos Osvaldo , Caneiras Cátia , Carriço Luís , Verdelho Ana 
Published: January 2024

Introduction Computer confidence and computer self-efficacy can impact an individual's perceived ease of use and usefulness of technology, ultimately determining adherence to digital healthcare services. However, few studies focus on assessing the impact of non-clinical factors on the efficacy and adherence to digital healthcare platforms. Objective We aimed to analyse the role of non-clinical factors (i.e. computer confidence and computer self-efficacy) in the interaction experience (IX) and the feasibility of a digital neuropsychological platform called NeuroVRehab.PT in a group of older adults with varying levels of computer confidence. Methods Eight older adults (70.63 ± 6.1 years) evaluated the platform, and data was collected using the Think-Aloud method and a semi-structured interview. Sessions were audio-recorded and analysed through an inductive-deductive informed Thematic Analysis protocol. This study was conducted according to the Consolidated Criteria for Reporting Qualitative Research guidelines. Results Three main themes were identified (Interaction Experience, Digital Literacy, and Attitudes toward NeuroVRehab.PT). Computer anxiety and fear of making errors were not uncommon, even among older adults who perceive themselves as confident in technology use, and negatively impacted IX. Moreover, some game elements (e.g. three-star system, progression bar) were not intuitive to all participants, leading to misleading interpretations. On the other hand, human support and the platform's realism seemed to impact participants’ IX positively. Conclusions This study shed light on the barriers raised by non-clinical factors in adopting and using digital healthcare services by older adults. Furthermore, a critical analysis of the platform's features that promote user adoption is done, and suggestions for overcoming limitations are presented.
CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment
Authors: Buldini Barbara , Varotto Elena , Maurer-Granofszky Margarita , Gaipa Giuseppe , Schumich Angela , Brüggemann Monika , Mejstrikova Ester , Cazzaniga Giovanni , Hrusak Ondrej , Szczepanowski Monika , Scarparo Pamela , Zimmermann Martin , Strehl Sabine , Schinnerl Dagmar , Zaliova Marketa , Karawajew Leonid , Bourquin Jean-Pierre , Feuerstein Tamar , Cario Gunnar , Alten Julia , Möricke Anja , Biffi Alessandra , Parasole Rosanna , Fagioli Franca , Valsecchi Maria Grazia , Biondi Andrea , Locatelli Franco , Attarbaschi Andishe , Schrappe Martin , Conter Valentino , Basso Giuseppe , Dworzak Michael N. 
Published: January 2024

Abstract
In the effort to improve immunophenotyping and minimal residual disease (MRD) assessment in acute lymphoblastic leukemia (ALL), the international Berlin-Frankfurt-Münster (iBFM) Flow Network introduced the myelomonocytic marker CD371 for a large prospective characterization with a long follow-up. In the present study, we aimed to investigate the clinical and biological features of CD371-positive (CD371pos) pediatric B-cell precursor ALL (BCP-ALL). From June 2014 to February 2017, 1812 pediatric patients with newly diagnosed BCP-ALLs enrolled in trial AIEOP-BFM ALL 2009 were evaluated as part of either a screening (n = 843, Italian centers) or validation cohort (n = 969, other iBFM centers). Laboratory assessment at diagnosis consisted of morphological, immunophenotypic, and genetic analysis. Response assessment relied on morphology, multiparametric flow cytometry (MFC), and polymerase chain reaction (PCR)-MRD. At diagnosis, 160 of 1812 (8.8%) BCP-ALLs were CD371pos. This correlated with older age, lower ETV6::RUNX1 frequency, immunophenotypic immaturity (all P &lt; .001), and strong expression of CD34 and of CD45 (P &lt; .05). During induction therapy, CD371pos BCP-ALLs showed a transient myelomonocytic switch (mm-SW: up to 65.4% of samples at day 15) and an inferior response to chemotherapy (slow early response, P &lt; .001). However, the 5-year event-free survival was 88.3%. Among 420 patients from the validation cohort, 27 of 28 (96.4%) cases positive for DUX4-fusions were CD371pos. In conclusion, in the largest pediatric cohort, CD371 is the most sensitive marker of transient mm-SW, whose recognition is essential for proper MFC MRD assessment. CD371pos is associated to poor early treatment response, although a good outcome can be reached after MRD-based ALL-related therapies.
Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus
Authors: Kong Xiang , Wan Shu-jun , Chen Tian-bing , Jiang Lan , Xing Yu-jie , Bai Ya-ping , Hua Qiang , Yao Xin-ming , Zhao Yong-li , Zhang Hong-mei , Wang De-guo , Su Qing , Lv Kun 
Published: January 2024

Abstract
Background
Extrachromosomal circular DNAs (eccDNAs) exist in human blood and somatic cells, and are essential for oncogene plasticity and drug resistance. However, the presence and impact of eccDNAs in type 2 diabetes mellitus (T2DM) remains inadequately understood.

Methods
We purified and sequenced the serum eccDNAs obtained from newly diagnosed T2DM patients and normal control (NC) subjects using Circle-sequencing. We validated the level of a novel circulating eccDNA named sorbin and SH3‐domain‐ containing‐1circle97206791–97208025 (SORBS1circle) in 106 newly diagnosed T2DM patients. The relationship between eccDNA SORBS1circle and clinical data was analyzed. Furthermore, we explored the source and expression level of eccDNA SORBS1circle in the high glucose and palmitate (HG/PA)-induced hepatocyte (HepG2 cell) insulin resistance model.

Results
A total of 22,543 and 19,195 eccDNAs were found in serum samples obtained from newly diagnosed T2DM patients and NC subjects, respectively. The T2DM patients had a greater distribution of eccDNA on chromosomes 1, 14, 16, 17, 18, 19, 20 and X. Additionally, 598 serum eccDNAs were found to be upregulated, while 856 eccDNAs were downregulated in T2DM patients compared with NC subjects. KEGG analysis demonstrated that the genes carried by eccDNAs were mainly associated with insulin resistance. Moreover, it was validated that the eccDNA SORBS1circle was significantly increased in serum of newly diagnosed T2DM patients (106 T2DM patients vs. 40 NC subjects). The serum eccDNA SORBS1circle content was positively correlated with the levels of glycosylated hemoglobin A1C (HbA1C) and homeostasis model assessment of insulin resistance (HOMA-IR) in T2DM patients. Intracellular eccDNA SORBS1circle expression was significantly enhanced in the high glucose and palmitate (HG/PA)-induced hepatocyte (HepG2 cell) insulin resistance model. Moreover, the upregulation of eccDNA SORBS1circle in the HG/PA-treated HepG2 cells was dependent on generation of apoptotic DNA fragmentation.

Conclusions
These results provide a preliminary understanding of the circulating eccDNA patterns at the early stage of T2DM and suggest that eccDNA SORBS1circle may be involved in the development of insulin resistance.