bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual 68Ga -DOTANOC and 18F -FDG PET/CT in metastatic gastrointestinal neuroendocrine neoplasms with or without surgical resection of the primary site
Authors: Cui Ruizhe , Zhang Bing , Wang Zhixiong , Liu Yifan , Tang Wei , Li Guanghua , Wang Zhao 
Published: October 2023

Abstract

Purpose
Gastrointestinal neuroendocrine neoplasms (GI-NEN) exhibit heterogeneity in biological behavior, making it difficult to predict prognosis. We established the P Grade based on 68Ga-DOTANOC and 18F-FDG PET dual scans and evaluated the prognostic significance in patients with metastatic GI-NEN who underwent either surgical resection of the primary tumor or medical treatment.
Methods
The P Grade was categorized based on SSTRI/FDG uptake into P1 (DOTANOC positive/FDG negative), P2 (DOTANOC positive/FDG positive), and P3 (DOTANOC negative/FDG positive). Patients were divided into medical treatment and surgical group. The correlation of P Grade with progression-free survival (PFS) and overall survival (OS) was evaluated using Kaplan-Meier analysis, and performed univariate and multivariate analyzes of relevant clinicopathological variables with PFS and OS.
Results
243 patients with metastatic GI-NEN were enrolled. P Grade exhibited significant correlation with OS and PFS in overall cohort on univariate and multivariate analysis (p < 0.01). In surgery group, P Grade demonstrated independent predictive value for OS and PFS (p < 0.01). In medical treatment group, P Grade demonstrated predictive value for PFS (all p < 0.01) and predicted OS (univariate P3vsP1, p < 0.01). Additional predictors of OS and PFS included WHO grade, age at diagnosis, location of primary site, sex and extrahepatic disease, they all had correlation with OS or PFS except sex factors.
Conclusion
Our study demonstrates that P Grade obtained by combining 68Ga-DOTANOC and 18F-FDG PET is a significant prognostic indicator for patients with metastatic GI-NEN, regardless of whether received medical treatment or surgical resection of the primary site. Prospective research is needed for further verification.
A facile synthesis of bridged polycyclic compounds consisting of chromeno-oxazocine- quinolin skeletons: Eight-Membered-Ring constructions via tandem dinucleophilic addition of 4- hydroxycoumarin to 1,10-phenanthrolin-1-ium Salts
Authors: Sayahi Mohammad Hosein , Habbibi Ahmad , Moazzam Ali , Hosseini Samanesadat , Larijani Bagher , Adib Mehdi , Bahadorikhalili Saeed , Mahdavi Mohammad 
Published: October 2023

Abstract
A novel and efficient tandem synthesis is described for the preparation of bridged polycyclic compounds consisting of chromeno-oxazocine-quinolin through a reaction between benzyl bromide, 1,10-phenanthroline, and 4-hydroxycoumarin in the presence of K2CO3 without a catalyst in tandem reaction. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials.
A novel SIV-infection Animal Model based on Nude Mice Inoculated with MT-2 Cells
Authors: Xie Lei , chen Xiuyun , Yin Mingyu , Li Junlin , Huang Wenguan , Luo Minyi , Liu Yatian , He Haolan , Zhang Xinyu , He Jinyang 
Published: October 2023

Abstract

To establish a new small animal model supporting Simian Immunodeficiency Virus (SIV) replication in vivo, male BALB/c nude mice, aged three weeks, were subjected to a single intraperitoneal injection of SIV-infected MT-2 cells (human T-cell leukemia cells). Subsequently, alterations in plasma viral load and the colonization of MT-2 cells in vivo were investigated, while changes in the immune system were assessed through ELISA and flow cytometry assays. Notably, all mice within the model group exhibited detectable plasma viral loads in peripheral blood, primarily attributed to the proliferation of SIV-infected MT-2 cells that replenished the T cells in nude mice and colonized the abdominal cavities and lymph nodes, thereby releasing free virions to sustain the infection. Importantly, it is noteworthy that the HAART group demonstrated a statistically significant decline in plasma viral loads. The administration of HAART partially reversed the trend of SIV-associated immune collapse. Reasonably, the model proposed within this study holds substantial potential as a valuable tool to evaluate the antiviral effects and efficacy of immune regulation in an in vivo setting.
Evaluating an Addiction Medicine Unit in Sudbury, Ontario Canada: A mixed-methods study protocol
Authors: Morin Kristen A , Ghartey Karla , Bodson Adele , Sirois Alexandra , Leary Tara 
Published: October 2023

Abstract
Background
In response to the escalating global prevalence of substance use and the specific challenges faced in Northern Ontario, Canada, an Addiction Medicine Unit (AMU) was established at Health Sciences North (HSN) in Sudbury. This protocol outlines the approach for a comprehensive evaluation of the AMU, with the aim of assessing its impact on patient outcomes, healthcare utilization, and staff perspectives.
Methods
We conducted a parallel mixed-method study that encompassed the analysis of single-center-level administrative health data and primary data collection, including a longitudinal observational study (target n = 1,200), pre- and post-admission quantitative interviews (target n = 100), and qualitative interviews (target n = 25 patients and n = 15 staff). We implemented a participatory approach to this evaluation, collaborating with individuals who possess lived or living expertise in drug use, frontline staff, and decision-makers across the hospital. Data analysis methods encompass a range of statistical techniques, including logistic regression models, Cox proportional hazards models, Kaplan-Meier curves, Generalized Estimating Equations (GEE), and thematic qualitative analysis, ensuring a robust evaluation of patient outcomes and healthcare utilization.
Discussion
This protocol serves as the foundation for a comprehensive assessment designed to provide insights into the AMU's effectiveness in addressing substance use-related challenges, reducing healthcare disparities, and improving patient outcomes. All study procedures have been meticulously designed to align with the ethical principles outlined in the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans. The findings will be disseminated progressively through committees and working groups established for this research, and subsequently published in peer-reviewed journals. Anticipated outcomes include informing evidence-based healthcare decision-making and driving improvements in addiction treatment practices within healthcare settings.
Retrieval of High-Resolution Aerosol Optical Depth (AOD) using Landsat 8 imageries over different LULC classes over a City along Indo-Gangetic Plain, India
Authors: Singh Rohit Kumar , Satyanarayana A. N. V. , Prasad P. S. Hari 
Published: October 2023

Abstract

Aerosol Optical Depth (AOD) serves as a crucial indicator for assessing regional air quality by quantifying aerosol levels in the atmosphere. While various satellite methods exist for estimating AOD, the spatial resolution of established AOD products is often limited. However, obtaining higher-resolution AOD data is essential for gaining a deeper understanding of regional and urban air pollution issues. To address this issue, we retrieved high-resolution AOD over Kanpur (26.4499° N, 80.3319° E), located in the Indo-Gangetic Plain (IGP) region using Landsat 8 imageries. We have used Landsat 8 imagery and the SEMARA algorithm, which combines SARA (Simplified Aerosol Retrieval Algorithm) and SREM (Simplified and Robust Surface Reflectance Estimation). Our approach leveraged the green band of the Landsat 8, resulting in an impressive spatial resolution of 30 meters. This methodology was applied over the period from 2014 to 2022 and rigorously validated with available AERONET observations. The retrieved AOD is in good agreement with high correlation coefficients (r) of 0.997, a low root mean squared error (RMSE) of 0.035, and root mean bias (RMB) of -4.91%. Furthermore, we conducted a comprehensive comparison with downscaled MODIS (MCD19A2) AOD products across various land classes for cropped and harvested period of agriculture cycle with different land use and land cover classes. The SEMARA approach proved to be more effective for AOD retrieval on brighter surfaces within the barren and built-up land categories for harvested period. This methodology holds great potential for monitoring aerosols over bright urban areas.
Integrative analysis of microbial 16S gene and shotgun metagenomic sequencing data improves statistical efficiency
Authors: Yue Ye , Read Timothy , Fedirko Veronika , Satten Glen , Hu Yi-Juan 
Published: October 2023

Abstract
Background: The most widely used technologies for profiling microbial communities are 16S marker-gene sequencing and shotgun metagenomic sequencing. Interestingly, many microbiome studies have performed both sequencing experiments on the same cohort of samples. The two sequencing datasets often reveal consistent patterns of microbial signatures, highlighting the potential for an integrative analysis to improve power of testing these signatures. However, differential experimental biases, partially overlapping samples, and differential library sizes pose tremendous challenges when combining the two datasets. Currently, researchers either discard one dataset entirely or use different datasets for different objectives.
Methods: In this article, we introduce the first method of this kind, named Com-2seq, that combines the two sequencing datasets for testing differential abundance at the genus and community levels while overcoming these difficulties. The new method is based on our LOCOM model (Hu et al., 2022), which employs logistic regression for testing taxon differential abundance while remaining robust to experimental bias. To benchmark the performance of Com-2seq, we introduce two ad hoc approaches: applying LOCOM to pooled taxa count data and combining LOCOM p-values from analyzing each dataset separately.
Results: Our simulation studies indicate that Com-2seq substantially improves statistical efficiency over analysis of either dataset alone and works better than the two ad hoc approaches. An application of Com-2seq to two real microbiome studies uncovered scientifically plausible findings that would have been missed by analyzing individual datasets.
Conclusions: Com-2seq performs integrative analysis of 16S and metagenomic sequencing data, which improves statistical efficiency and has the potential to accelerate the search of microbial communities and taxa that are involved in human health and diseases.
A study of the correlation between radiologic parameter changes and triangular fibrocartilage complex injury after distal radius fracture
Authors: Li Linwei , Tan Chunye , Wang Zeyu 
Published: October 2023

Abstract
Background
Triangular fibrocartilage complex (TFCC) injury is a frequent soft tissue injury that has been observed to accompany distal radius fractures (DRFs) with concomitant changes in radiologic parameters. The aim of this study was to investigate the relevance of distal radial radiologic parameters associated with DRF and traumatic TFCC injury.
Methods
A total of 172 patients with distal radius fractures who underwent X-ray, CT, and MRI before undergoing volar locking plate or external splint fixation between October 2021 and December 2022 were included in this study. An analysis of various radiologic parameters and the classification of fracture type and TFCC injuries by CT and MRI was performed. All patients were divided into the TFCC uninjured group and the injured group. The incidence and relevant radiologic parameters were compared.
Results
This study included 76 males and 96 females with a mean age of 56.1 years. Among all patients, 33 (19.2%), 40 (23.2%), and 99 (57.6%) had DRF with A, B and C fractures, respectively, according to the AO/OTA classification. In patients with fractures, the TFCC was found to be injured in 54.1% (93/172) of patients (type 1A in 21, 1B in 46, 1C in 39, and 1D in 35) but uninjured in 45.9% (79/172). There were significant differences between the TFCC injured and uninjured groups regarding the radius length (p = 0.044) and DRUJ distance (p = 0.040) of radiologic parameters that changed with DRF, although there were no differences between the two groups regarding gender, age, injured side, intra- and extra-articular, radius inclination and palmer tilt angle, or sagittal translation. Within the TFCC injured group, the radius length and DRUJ distance were 4.83 mm and 2.95 mm less or wider than 7.19 mm and 1.83 mm of the uninjured group. Moreover, shorter radius length was related to type lB TFCC injury (p = 0.041). Both radius length (AUC = 0.658) and DRUJ distance (AUC = 0.582) had no convincing predictive value for TFCC injury in DRF.
Conclusion
1B TFCC injury is most common in patients with DRF and concomitant TFCC injury. Both radius length and DRUJ distance have a significant statistical correlation with TFCC injury and patients with TFCC injury tend to have a shortened radius and wider DRUJ distance, although they have no predictive value for TFCC injury in DRF. In addition, a shorter radius length was related to type lB TFCC injury.
The relationship between prognosis and temporal muscle thickness in 102 patients with primary glioblastoma:real-world evidence
Authors: Tang Jinhai , Dong Zhenghao , Yang Lei , Yang Ping , Zhao Wanying , Deng Lvdan , Xue Juan , Cui Yijie , Li Qizheng , Tang Lufan , Sheng Junxiu , Zhang Yu , Zhang Huimin , Chen Tongtong , Lv Li , Lv Xiupeng 
Published: October 2023

Abstract
Temporal muscle thickness measured on 3D MRI has recently been linked to prognosis in glioblastoma patients and may serve as an independent prognostic indicator. This single-center study looked at temporal muscle thickness and prognosis in patients with primary glioblastoma. Overall survival was the major study outcome. For a retrospective analysis from 2010 to 2020, clinical data from 102 patients with glioblastoma at the Department of Oncology Radiotherapy of the First Affiliated Hospital of Dalian Medical University were gathered. Of these, 55 cases from 2016 to 2020 included glioblastoma molecular typing data, which were analyzed separately.TMT was measured using improved T1-weighted magnetic resonance imaging at the time of GBM diagnosis. The overall survival (OS) of the patients was calculated using the Kaplan-Meier technique, the differences between the groups were assessed using the log-rank test, and the clinical outcomes of the two groups were compared using the Cox proportional risk model and multifactorial analysis. In 102 patients, the median TMT was 6.775 mm (range 4.95–10.45). Patients were grouped according to median TMT, and those in the TMT > median group had a considerably longer median overall survival (23.0 months) than those in the TMT median group (P 0.001; Log-rank test). Data from 55 cases containing molecular staging of glioblastoma alone were analyzed, and the median overall survival of patients in the TMT > median group (17.5 months) was significantly increased compared with the median overall survival of patients in the ≤ median group (9 months) (P < 0.001; Log-rank test). We can concluded that TMT can serve as an independent predictor of survival prognosis in patients with primary GBM, as well as in the era of molecular typing.
Prevalence of Vitamin D deficiency and its association with cardiometabolic risk factors among healthcare workers in the Eastern Cape province, South Africa; Cross-Sectional Study
Authors: Adeniyi Oladele Vincent , Masilela Charity , George Jaya A. 
Published: October 2023

Abstract
Introduction:
There is little evidence supporting the association of known cardiometabolic risk factors with vitamin D deficiency across different population groups in South Africa. This study assesses the prevalence of Vitamin D deficiency and its potential association with cardiometabolic risk factors among South African adults residing in the Eastern Cape province.
Methods
In this cross-sectional study, a total of 1244 healthcare workers completed a self-administered questionnaire and venous blood samples were drawn at two academic hospitals in the Eastern Cape province. Vitamin D [25(OH)D] deficiency was defined as concentrations < 50 nmol/L. Associations between vitamin D deficiency and participants’ characteristics were assessed using multivariate logistic regression model analysis, with a 95% confidence interval (95% CI).
Results
A total of 355 participants (28.54% of the study sample) met the criteria for vitamin D deficiency, of whom 28.81% (n = 293) were female. The prevalence of obesity (BMI ≥ 30 kg/m2), diabetes mellitus, hypertension, chronic kidney disease, and metabolic syndrome was 64.51% (n = 229), 9.01% (n = 32), 16.62% (n = 59), 2.53% (n = 08) and 18.02% (n = 64), respectively. In the adjusted multivariate logistic regression model, black participants (AOR = 6.85 95%CI 0.93–15.99) were more likely to be deficient in vitamin D. However, there was no significant association by age, sex, and cardiometabolic markers in the study sample (p > 0.05).
Conclusions
More than one in four healthcare workers was deficient in vitamin D among the study sample, especially among the black Africans. Further studies are needed at the population level, especially minority ethnicity to elucidate on the vitamin D status in the region.
Formation of erbium-doped tellurite-modified silica film via femtosecond laser ablation
Authors: Kamil Suraya Ahmad , Jose Gin 
Published: October 2023

Abstract
Femtosecond (fs) laser technology has evolved as an alternative technique to fabricate thin film by blending the plasma produced from the target material with a substrate. This ultrafast laser was used to fabricate the erbium-doped tellurite-modified silica (EDTS) thin film that is beneficial for optical waveguide and laser applications. There are several very important parameters in this process, among which are the conditions of the substrate used and also the time required to obtain a certain thickness. Film thickness increases with time; however, there is a limitation whereby the substrate becomes fragile at a certain period due to exposure to particle bombardment that has very high energy for a long period. For the sample where the EDTS reaches the surface of the sample substrate, there are small crystallites appear at the interface between the silicon and the EDTS. On the other hand, the fs laser ablation process is quite challenging for a short period because the film obtained is not completely uniform.
Neurodevelopmental Outcomes Following Aortic Surgery in the Paediatric Population
Authors: Vivekanandan Govinathan , Ndokotsu Andrew , Yubbu Putri , Munusamy Mathan Mohan , Sivaratnam Dhashani , Devaraj Navin Kumar , Romli Muhammad Hibatullah , Leong Ming Chern 
Published: October 2023

Abstract
Introduction: Complex aortic surgeries during infancy may affect the neurodevelopmental of children. The study aimed to outline the neurological outcomes and probable risk factors in patients who had undergone aortic surgeries during infancy. Method: A systematic search of English language articles from Academic Search Complete, Cochrane Database, MEDLINE, ScienceDirect, and Scopus was performed. Studies using tools to assess neurodevelopmental outcomes in the pediatric population who underwent aortic surgery in infancy were reviewed. Studies with non-aortic surgeries and prior neurological comorbidities were excluded. Results: Eight cohort studies and two randomized control trials involving 2776 patients were included. Wechsler Intelligent Scale (WIS) (67%) was the most commonly used tool to measure IQ followed by the Bayley Infant Development scale (BIDS). Two studies reported a lower psychomotor developmental index score in 25% of their cohort. Approximately 32% demonstrated a poor Full Scale Intelligent Quotient of less than 70. Motor dyspraxia was the most commonly reported neurological dysfunction (50%). Low weight at surgery and longer surgical duration affect the neurocognitive process. Conclusions: Complex aortic surgeries and their perioperative course leave significant neurocognitive complications which may be progressive into adulthood. This study suggests that infants undergoing complex aortic surgery would benefit from long-term neurocognitive surveillance to identify emerging complications.
TCRαβ-depleted hematopoietic stem cell transplant and third-party CD45RA+ depleted adoptive cell therapy for treatment of post-transplant parvovirus B19 aplastic crisis
Authors: Chen Jing , Zhang Manping , Luo Chengjuan , Wang Jianmin , Zhu Hua , Luo Changying , Qin Xia , huang xiaohang , Lin Yuchen 
Published: October 2023

Abstract
This is a case report of a 6-year-old girl with relapsed B cell acute lymphoblastic leukemia in which adoptive cell therapy was successfully applied to treat refractory HPV B19 infection. Allogenic-CAR T-cell therapy (bispecific CD19/CD22) bridged to HSCT was performed using a haploidentical paternal donor. However, HPV B19 DNAemia progressed and a transfusion-related graft versus host disease occurred. After finding a third party related donor with a better HLA match haploidentical HPV B19- seropositive CD45RA+ depleted cells (16.5×106/kg) were administered and the HPV B19 DNAemia became negative within one week and reticulocyte, neutrophil, hemoglobin, and platelet counts gradually normalized. The patient remained stable during the one-year outpatient follow-up period. Our case report highlighted that persistent B19 infection can lead to pancytopenia, aplastic crisis, and graft rejection. TCRαβ+ depleted haplo-HSCT is an effective way to quickly achieve hematopoiesis recovery. CD45RO memory T cell therapy is the key to treating and preventing the development of refractory severe HPV B19 infection.
Piperacillin−tazobactam versus cefotaxime as empiric treatment for febrile urinary tract infection in children
Authors: Han Kyoung Hee , Oh Minsu , Ahn Jeongmin , Lee Juyeon , Kim Yeonu , Yoon Young Mi , Kim Yoon−Joo , Kang Hyun Sik , Kang Ki−Soo , Greenbaum Larry A. , Choi Jae Hong 
Published: October 2023

Abstract
Urinary tract infections (UTI) are one of the most common infections in children. The proportion of extended − spectrum beta − lactamase (ESBL) − producing bacteria in pediatric UTIs is increasing. Therefore, it is necessary to pay attention to the use of antibiotics to prevent ESBL − producing bacteria in patients susceptible to infections in medical institutions. This study aimed to investigate the clinical features related to the recurrence of UTI in children and to confirm the experience and validity of piperacillin − tazobactam (TZP) as a first − line treatment. Medical records of pediatric patients diagnosed with febrile UTI between January 2014 and February 2017 were retrospectively reviewed. Patients were grouped according to the antimicrobials they received. Clinical characteristics and treatment outcomes in terms of recurrent UTI were compared between the groups. Our findings demonstrate significant variations in the clinical characteristics of UTIs depending on the age of onset. Further, we found that 18.3% of community − acquired UTIs were caused by ESBL − positive bacteria. Regarding the empiric treatment for febrile UTI in children ≥ 3 months, there was no significant difference in recurrence between the cefotaxime − treated group and TZP − treated group. Thus, TZP can be considered an alternative to cefotaxime for febrile UTI in infants and children ≥ 3 months of age.