bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ecological approach to creating validating support for low‐income, racially minoritized, and first‐generation college students
Authors: Hallett Ronald E. , Kezar Adrianna , Kitchen Joseph A. , Perez Rosemary J. , Reason Robert 
Published: January 2024

AbstractDrawing from a longitudinal mixed methods study, this article explores how postsecondary institutions can create a campus‐wide culture of validation that can improve at‐promise student experiences and outcomes. The authors share several strategies that instructors, staff, and administrators can collaboratively enact to build a culture of ecological validation.Practical Takeaways
Creating a culture of ecological validation enables postsecondary institutions to move away from siloed approaches that have been ineffective in supporting at‐promise students.
Grounded in institutional norms (proactive, identity‐conscious, strengths‐oriented, holistic, developmental, collaborative and reflective), this approach enables educators to reimagine how they approach their work with students.
Pretreatment fat‐free mass index correlates with early death in patients with head and neck squamous cell carcinoma
Authors: Talani Charbél , Astradsson Thorsteinn , Farnebo Lovisa , Mäkitie Antti , Ehrsson Ylva Tiblom , Laurell Göran 
Published: January 2024

AbstractBackgroundA significant proportion of patients with head and neck squamous cell carcinoma (HNSCC) are malnourished at diagnosis. In this study, we investigated how pretreatment body mass index (BMI) and fat‐free mass index (FFMI) correlate with early death, and whether these measurements are useful markers of prognosis for risk stratification of head and neck cancer patients.MethodsPatients (n = 404) with newly diagnosed, curable HNSCC and WHO performance status 0–2 were prospectively included and met with a study representative before treatment initiation, as well as up to four follow‐up visits. All patients provided an estimate of body weight at 6 months prior to diagnosis. Bioelectrical impedance analysis (BIA) was performed for all patients before treatment initiation.ResultsMost patients had oropharyngeal (46%), oral cavity (28%), or laryngeal cancer (12%). Forty‐five (11%) patients met the standardized criteria for malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) at diagnosis. FFMI at diagnosis was lower in patients who died within 6 and 12 months after the start of treatment than in patients who survived these time points (p = 0.035 and p = 0.005, respectively).ConclusionsIn this study, pretreatment FFMI was an independent prognostic factor for death within 6 and 12 months after the start of treatment in patients with HNSCC. Pretreatment BMI was not an independent risk factor for death within 6 and 12 months after treatment termination. Thus, FFMI may be useful for risk stratification of patients with head and neck cancer.
Synthesis and Photophysical Evaluation of 3,3’‐Nitrogen Bis‐Substituted fac‐[Re(CO)3(Diimine)Br] Complexes
Authors: Csucker Joshua , Decrausaz Nathalie , Jäggi Sarah Isabella , Blacque Olivier , Spingler Bernhard , Alberto Roger 
Published: January 2024

AbstractThe preparations, photophysical and electrochemical properties of a series of fac‐[Re(CO)3(diimine)Br] complexes are presented. The bipyridine (bpy) based diimine ligands feature symmetrical and asymmetrical 3,3’‐diamino‐2,2’‐bipyridine substitution patterns. Photophysical and electrochemical properties of these complexes are tunable, depending on their organic diimine framework. Introduction of a distal urea bridge via the 3,3’‐substitution pattern led to prolonged phosphorescence lifetimes without a significant change in absorbance and phosphorescence emission wavelengths. Reversible electrochemical bipyridine reduction remained largely unchanged by this derivatization.
Oral health knowledge, attitudes and practices of dietitians in Australia: A national survey
Authors: Patterson‐Norrie Tiffany , Ramjan Lucie , Sousa Mariana S. , Kezhekkekara Shwetha , George Ajesh 
Published: January 2024

AbstractAimDietitians are a well‐placed profession to be providing pre‐emptive oral health promotion. Despite recommendations that oral health promotion should be routinely part of dietetic practice, there is limited data informing the current practices of clinical dietitians in this area across Australia. Hence, the aim of this study was to investigate the knowledge and practices of Australian dietitians and oral health promotion.MethodsA cross‐sectional survey was undertaken involving registered clinical dietitians in Australia using purposive and snowballing sampling (social media/dietetic organisations/public databases). Data were analysed using descriptive and inferential statistics.ResultsA total of 149 dietitians participated in the national survey. Overall, dietitians were knowledgeable about oral health risk factors and preventative measures across general health domains. Majority of dietitians agreed that oral health can affect nutrition interventions (95.5%) and dietitians should be discussing oral health (88.0%). However, nearly half were not confident in providing counselling or education and felt that undergraduate training for oral health promotion was inadequate (78.2%). A small proportion (6.0%) of dietitians were already providing oral health promotion regularly. Key barriers included a lack of clear guidelines for practice, limited training opportunities and indistinct referral pathways.ConclusionDietitians have acknowledged that oral health promotion should be incorporated into their practice. However, they are challenged by a lack of resources and training to support this in clinical practice.So What?Capacity building dietitians to promote oral health allows opportunity for improvement in the oral health, nutritional status and quality of life of priority population groups.
La nature de la liaison d'hydrogène
Authors: Prigogine I. 
Published: January 2024

RÉSUMÉLe déplacement de la fréquence de vibration de valence OH, mesurable par la spectroscopie infra‐rouge, permet l‘évaluation approchée de l‘énergie d'association.Les valeurs ainsi obtenues grâce aux mesures de Gordy; de J. Errera, Gaspart et Sack, ainsi que de l'auteur sont en faveur de l'interprétation électrostatique de la liaison d'hydrogène. En particulier on observe que l'énergie d'association ne subit pas de modification sensible en remplaçant l'hydrogène par le deutérium. La liaison d'hydrogène ne peut donc résulter d'un effet de résonance quantique dont l'importance devrait diminuer considérablement en remplaçant l'hydrogène par le deutérium de masse double.Ces résultats confirment les vues développées notamment par K. L. Wolf et son école, ainsi que par Bauer et Magat concernant la nature électrostatique de la liaison d'hydrogène.
Sur la détermination de l'isomérie cis‐trans des dialkyl.1‐2. cyclopentanes au moyen de leurs vitesses de réaction
Authors: Chiurdoglu Grégoire 
Published: January 2024

RésuméLes dialkyl.1.2.cyclopentanes d'une même configuration se comportent, tant au point de vue physique qu'au point de vue chimique, d'une manière identique. En particulier, les diméthyl.1.2.cyclopentanes, méthyl.1.éthyl. 2.cyclopentanes, méthyl.1.propyl.2.cyclopentanes et les diéthyl.1.2.cyclopentanes les moins volatils se broment et s'oxydent plus vite que ceux bouillant le plus bas. On en conclut que, contrairement à ce que veut la règle d'Auwers‐Skita, les premiers sont des isomères trans, les seconds des isomères cis, car tel est également le comportement, vis‐à‐vis de l'oxygène, des hydrocarbures aux configurations spatiales établies, comme les diméthyl.1.3.cyclohexanes et les décalanes stéréoisomères.
Les phases superficielles idéales à adsorption mobile
Authors: Defay Raymond , Prigogine I. 
Published: January 2024

RésuméDans les systèmes en équilibre, nous appelons phase superficielle idéale à adsorption mobile ou plus brièvement surface idéale, une phase superficielle à adsorption mobile dont les constituants ont des potentiels chimiques de la forme
Assessing trans‐endothelial transport of nanoparticles for delivery to abdominal aortic aneurysms
Authors: Yau Jimmy , Chukwu Patience , Jedlicka Sabrina S. , Ramamurthi Anand 
Published: January 2024

AbstractAbdominal aortic aneurysms (AAAs) are localized, rupture‐prone expansions of the abdominal aorta wall. In this condition, structural extracellular matrix (ECM) proteins of the aorta wall, elastic fibers and collagen fibers, that impart elasticity and stiffness respectively, are slowly degraded by overexpressed matrix metalloproteinases (MMPs) following an injury stimulus. We are seeking to deliver therapeutics to the AAA wall using polymer nanoparticles (NPs) that are capable of stimulating on‐site matrix regeneration and repair. This study aimed to determine how NP shape and size impacts endocytosis and transmigration past the endothelial cell (EC) layer from circulation into the medial layer of the AAA wall. First, rod‐shaped NPs were shown to be created based mechanical stretching of PLGA NPs while embedded in a PVA film with longer rod‐shaped NPs created based of the degree in which the PVA films are stretched. Live/dead assay reveals that our PLGA NPs are safe and do not cause cell death. Immunofluorescence staining reveal cytokine activation causes endothelial dysfunction in ECs by increasing expression of inflammatory marker Integrin αVβ3 and decreasing expression of adhesion protein vascular endothelial (VE)‐cadherin. We showed this disruption enable greater EC uptake and translocation of NPs. Fluorescence studies demonstrate high endothelial transmigration and endocytosis with rod‐shaped NPs in cytokine activated ECs compared to healthy control cells, arguing for the benefits of using higher aspect ratio (AR) NPs for accumulation at the aneurysm site. We also demonstrated that the mechanisms of NP transmigration across an activated EC layer depend on NP AR. These results show the potential of using shape as a modality for enhancing permeation of NPs into the aneurysm wall. These studies are also significance to understanding the mechanisms that are likely engaged by NPs for penetrating the endothelial lining of aneurysmal wall segments.
Anaerobic photocyclization of ortho‐dialkylamino substituted stiff‐stilbenes
Authors: Hung Yi‐Ning , Wang Yi‐Ching , Chen Zi‐Jian , Yang Jye‐Shane 
Published: January 2024

AbstractThe photocyclization of diarylethenes toward polycyclic aromatic hydrocarbons and analogs has been well‐documented. However, stiff‐stilbene was reported to be inactive, and examples of photocyclization‐induced deamination remain unknown. Here, we report that ortho‐(N,N‐dimethylamino)‐stiff‐stilbene (1a) undergoes efficient photocyclization‐induced deamination, forming the dicyclopenta‐fused phenanthrene (DCPP) with good yield (65%) under anaerobic conditions. The relative reactivities of stiff‐stilbenes with different o‐amino substituents (1b–1g) or with an o‐methoxy (1h) group, and those of o‐(N,N‐dimethylamino)stilbenes (2a and 2aMe), provide insights into the substituent and structural effects.
Man up! The mental health‐feminine stereotype and its effect on the adoption of mental health apps
Authors: Lee Jaewoo , Trudel Remi 
Published: January 2024

AbstractMental illnesses are among the most frequent health conditions worldwide, affecting both men and women. However, we find that men are more likely than women to avoid adopting mobile apps that are designed to promote users' mental health. Building on previous research that men are often more motivated than women to behave in gender‐congruent ways, we suggest that there exists a mental health‐feminine stereotype that acts as an obstacle to men's adoption of mental health apps. Privacy and self‐help features offered by digital mental health apps are insufficient to overcome the mental health‐stereotype that deter men from pursuing mental health support. Across five studies, we show that consumers feel more feminine when adopting mental health apps, and perceive others who adopt mental health apps to be more feminine than those who do not. We also show that presenting mental health apps in a masculine frame increases the likelihood of men adopting mental health apps, especially those with stronger adherence to traditional masculinity ideology.
A beginner's guide to study extracellular vesicles in human blood plasma and serum
Authors: Nieuwland Rienk , Siljander Pia R‐M 
Published: January 2024

AbstractBlood is the most commonly used body fluid for obtaining and studying extracellular vesicles (EVs). While blood is a standard choice for clinical analysis, using blood as a source of EVs introduces multiple layers of complexity. At the Blood Extracellular Vesicle Workshop organized by the International Society for Extracellular Vesicles in Helsinki (2022), it became evident that beginner researchers lack trustworthy information on how to initiate their research and avoid common pitfalls. This educational guide explains the composition and frequently used terminology of blood, provides guidelines for blood collection, and the preparation of plasma and serum. It also introduces the basic principles of isolating and detecting blood EVs while considering blood‐related factors. The goal of this guide is to assist beginners by offering a concise and evidence‐based introduction to the current knowledge and available resources to study blood EVs.
Assessing HIV risk and the social and behavioural characteristics of gay and bisexual men who have recently migrated to Australia: an analysis of national, behavioural surveillance data 2019–2021
Authors: Yu Simin , Bavinton Benjamin R. , Chan Curtis , MacGibbon James , Mao Limin , Vujcich Daniel , Broady Timothy R. , Holt Martin 
Published: January 2024

AbstractIntroduction:Overseas‐born gay and bisexual men (GBM) are overrepresented in HIV diagnoses in Australia. We assessed social and sexual behaviours, and the use of HIV prevention and testing, by region of birth and length of residence in Australia. We sought to identify similarities and differences between recently arrived and non‐recently arrived GBM from non‐English‐speaking countries to improve targeting and engagement with HIV testing and prevention.Methods:Data were collected in national repeated, behavioural surveillance surveys conducted across Australia during 2019–2021. Logistic regression was used to identify factors that differentiated between recently arrived (<2 years) and non‐recently arrived (≥2 years in Australia) GBM from non‐English‐speaking countries.ResultsAmong 24,707 participants in 2019–21, 2811 (11.4%) were from high‐income English‐speaking countries, 714 (2.9%) were recently arrived overseas‐born GBM and 3833 (15.5%) were non‐recently arrived migrants. Recently arrived GBM were most likely to be born in Asia (36.1%) and Europe (21.1%). Compared with non‐recently arrived GBM, recently arrived GBM from non‐English‐speaking countries were younger (aOR = 0.95, 95% CI = 0.94–0.96, p<0.001), more likely to be students (aOR = 1.43, 95% CI = 1.11–1.85, p = 0.005), less likely to be in full‐time employment (aOR = 0.56, 95% CI = 0.46–0.69, p <0.001), more likely to report consistent condom use (aOR = 1.30, 95% CI = 1.01–1.66, p = 0.039), but had lower awareness (aOR = 0.62, 95% CI = 0.48–0.80, p<0.001) and use of pre‐exposure prophylaxis (PrEP) (22.8%, vs. 32.3%, χ2(1, 4185) = 23.78, p<0.001), and similar levels of casual sex with a risk of HIV acquisition or transmission (aOR = 1.29, 95% CI = 0.98–1.69, p = 0.066). Recently arrived GBM reported similar levels of lifetime HIV testing (aOR = 0.97, 95% CI = 0.54–1.74, p = 0.915) and recent HIV testing (OR = 1.03, 95% CI = 0.86–1.22, p = 0.779), but were much less likely to have tested at general practitioners (aOR = 0.53, 95% CI = 0.41–0.68, p<0.001) and more likely to report testing at hospitals (aOR = 3.35, 95% CI = 2.53–4.43, p<0.001), at home (aOR = 2.85, 95% CI = 1.63–4.99, p<0.001), or community‐based services (aOR = 1.36, 95% CI = 1.01–1.84, p = 0.043).ConclusionsRecently arrived GBM from non‐English‐speaking countries reported similar levels of risk of HIV acquisition to longer‐term residents in Australia, but lower levels of PrEP awareness and use, and more reliance on HIV testing services which are free or low cost. It is necessary to enhance access to HIV testing and prevention among recently arrived GBM in Australia.
Using qualitative comparative analysis as a mixed methods synthesis in systematic mixed studies reviews: Guidance and a worked example
Authors: El Sherif Reem , Pluye Pierre , Hong Quan Nha , Rihoux Benoît 
Published: January 2024

AbstractQualitative comparative analysis (QCA) is a hybrid method designed to bridge the gap between qualitative and quantitative research in a case‐sensitive approach that considers each case holistically as a complex configuration of conditions and outcomes. QCA allows for multiple conjunctural causation, implying that it is often a combination of conditions that produces an outcome, that multiple pathways may lead to the same outcome, and that in different contexts, the same condition may have a different impact on the outcome. This approach to complexity allows QCA to provide a practical understanding for complex, real‐world situations, and the context of implementing interventions. There are guides for conducting QCA in primary research and quantitative systematic reviews yet, to our knowledge, no guidance for conducting QCA in systematic mixed studies reviews (SMSRs). Thus, the specific objectives of this paper are to (1) describe a step‐by‐step approach for novice researchers for using QCA to integrate qualitative and quantitative evidence, including guidance on how to use software; (2) highlight specific challenges; (3) propose potential solutions from a worked example; and (4) provide recommendations for reporting.
Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis
Authors: Lam Brandon , Miller Jonas , Kung Yu Jui , Wu T.C. , Hung Chien‐Fu , Roden Richard B.S. , Best Simon R. 
Published: January 2024

ObjectivesRecurrent respiratory papillomatosis (RRP) is caused by human papilloma virus (HPV) infection of the aerodigestive tract that significantly impacts quality‐of‐life including the ability to communicate and breathe. Treatment was traditionally limited to serial ablative procedures in the O.R. with possible local adjuvant therapy, but new systemic therapies, such as Vascular endothelial growth factor (VEGF) inhibitors, are showing significant promise. This study aims to determine whether rationale exists for combination therapeutic approaches using VEGF inhibitors and/or immune checkpoint blockade.MethodsUsing fresh specimens from the O.R., we performed flow cytometry on papilloma, normal adjacent tissue, and blood. Papilloma and surrounding tissue were examined for expression of PD‐L1, PD‐L2, Galectin‐9, VEGFR2, and VEGFR3. CD8+ and CD4+ T cells were assayed for expression of PD‐1, TIGIT, LAG3, and TIM3.ResultsOur data shows that papilloma tissue exhibits significantly higher levels of PD‐L1 and PD‐L2 compared to adjacent tissue. Elevated levels of the VEGF receptor VEGFR3 were also observed in papilloma tissue. When examining T cells within the papilloma, elevated PD‐1 and TIGIT expression was observed on CD8+ T cells, while levels of PD‐1, TIGIT, and TIM3 were elevated on CD4+ T cells compared to PBMCs. Heterogenous marker expression was observed between individuals.ConclusionsOur analysis shows that RRP tissue shows elevated levels of multiple immune check point targets and VEGFR3, with varied patterns unique to each papilloma patient. Some of these immune checkpoint markers already have novel immunotherapies available or in development, providing molecular rationale to offer these systemic treatments to selected patients affected by RRP alongside VEGF inhibitors. Laryngoscope, 134:2819–2825, 2024
Relevant Research of Inflammatory Cytokines Spectrum in Peripheral Blood of Sudden Hearing Loss
Authors: Tan Xinyuan , Pan Jing , Cai Jieqing , Jiang Shanshan , Shu Fan , Xu Muqing , Peng Hua , Tang Jie , Zhang Hongzheng 
Published: January 2024

ObjectiveTo investigate whether there is a correlation between the inflammatory state and the pathogenesis and clinical features of sudden hearing loss (SHL) by studying the expression of inflammation‐related cytokines in the peripheral blood of patients with SHL.MethodsIn this work, we analyzed the cytokine profiles of 48 analytes in 38 patients with SHL compared to 38 healthy donors using a multiplex immunoassay. This study used appropriate statistical methods to screen for inflammatory cytokines associated with the pathogenesis of SHL, to analyze their network correlation, and to analyze the relationship between clinical features of SHL and inflammatory cytokines.ResultsSeveral cytokines, including CTACK, Eotaxin, HGF, INF‐α2, IFN‐β, IL‐1β, IL‐1ra, IL‐2Rα, IL‐4, IL‐7, IL‐8, IL‐9, IL‐10, IL‐12(p40), IL‐13, MIG, β‐NGF, SCF, and TNF‐α, exhibited significantly higher levels in the peripheral blood of the SHL group compared to the control group. An inflammatory network composed of multiple cytokines, including IL‐1β, is a risk factor for the development of SHL.ConclusionThis study identified several inflammatory cytokines with elevated expression, which may be linked with the onset of SHL. The results of this study also provide a basis for the theoretical hypothesis of inflammation in SHL.Level of Evidence3 Laryngoscope, 134:3293–3301, 2024
Physiological mortality of planktonic ciliates: Estimates, causes, and consequences
Authors: Weisse Thomas 
Published: January 2024

AbstractContrasting physiological mortality with predator‐induced mortality is of tremendous importance for the population dynamics of many organisms but is difficult to assess. This is especially true for tiny organisms, such as most protists, which do not leave any carcasses behind. I performed a meta‐analysis using planktonic ciliates as model organisms to estimate the maximum physiological mortality rates (δmax) across pelagic ecosystems in relation to environmental and biotic factors. The median δmax of planktonic ciliates was 0.62 d−1 and did not differ between marine and freshwater species. Maximum ciliate mortality rates were species‐specific and affected by their specific growth rates (rmax), cell volume, and ability to encyst. Cyst‐forming species had, on average, higher δmax than species unable to encyst. Maximum mortality rates were positively related to rmax, but, in contrast to the latter, δmax appeared unaffected by temperature. I conclude that (1) in the ocean, physiological mortality is more critical for controlling ciliate population size than ciliate losses imposed by microcrustacean predation, but (2) in many lakes, the opposite holds; (3) cyst formation is an effective ciliate trait to cope with the high mortality of motile cells upon starvation. The lack of a temperature effect on δmax deserves further study; if correct, planktonic ciliates may take advantage of rising ocean and lake temperatures, with important implications for the pelagic food web.