bluuebunny/crossref_metadata_2025_split huggingface dataset:
B‐P Coupling: Metal Stabilized Phosphinoborate Complexes
Authors: Gayen Sourav , Shyamal Sampad , Mohapatra Stutee , Antharjanam P. K. Sudhadevi , Ghosh Sundargopal 
Published: November 2023

AbstractIn an effort to establish B‐P coupling reactions without the use of phosphine‐borane dehydrocoupling agent, we have developed a new synthetic methodology employing group 8 metal σ‐borate complex [{κ3‐H,S,S′‐BH2L2}Ru{κ3‐H,H,S‐BH3L}] (L=NC5H4S), 1. Treatment of 1 with chlorodiphenyl phosphine (PPh2Cl) yielded 1,5‐P,S chelated Ru‐dihydridoborate species [PPh2H{κ3‐H,H,S‐BH(OH)L}Ru{κ2‐P,S‐(Ph2P)BH2L}], 2. The insertion of phosphine moiety (PPh2) by the cleavage of 3c–2e σ(Ru…H‐B) bonding interaction led to the formation of B‐P bond. The κ2‐P,S chelated six‐membered ring adopted a boat conformation in complex 2. The heterocycle is made of all different atoms, which is one of the rarest examples of heteroatomic ring systems. Theoretical outcomes demonstrated the electronic insight of B‐P coupling and stabilization through transition metal. In order to explore an alternate route of B‐P bond formation, we have further explored the reaction of 1 and Ru‐bis(dihydridoborate) complex, 5 with secondary phosphine oxide (SPO). Although, thermolysis of 1 with diphenylphosphine oxide yielded analogous σ‐borate complex 3, the similar reaction of 5 at room temperature led to the formation of novel phosphinous(III) acid incorporated Ru(σ‐borate)(dihydridoborate) complex, 6. In a similar fashion, the reaction of 5 with phosphite ligand generated Ru(σ‐borate)(dihydridoborate) complex, 7, which is analogous to 6.
The neurovascular unit of capillary blood vessels in the rat nervous system. A rapid‐Golgi electron microscopy study
Authors: Larriva‐Sahd Jorge , Martínez‐Cabrera Gema , Lozano‐Flores Carlos , Concha Luis , Varela‐Echavarría Alfredo 
Published: November 2023

AbstractWe describe a pericapillary organ in the rat forebrain and cerebellar cortex. It consists of a series of tripartite synapses with synaptic extensions enveloped by astrocytic endfeet that are linked to the capillary wall by synaptic extensions. Reciprocal specializations of the pericyte‐capillary blood vessel (CBV) with such specialized synapses suggest a mechanoreceptor role. In Golgi‐impregnated and 3D reconstructions of the cerebral cortex and thalamus, a series of TSs appear to be sequentially ordered in a common dendrite, paralleled by synaptic outgrowths termed golf club synaptic extensions (GCE) opposed to a longitudinal crest (LC) from the capillary basal lamina (BL). Our results show that, in the cerebellar cortex, afferent fibers and interneurons display microanatomical structures that strongly suggest an interaction with the capillary wall. Afferent mossy fiber (MF) rosettes and ascending granule cell axons and their dendrites define the pericapillary passage interactions that are entangled by endfeet. The presence of mRNA of the mechanosensitive channel Piezo1 in the MF rosettes, together with the surrounding end‐feet and the capillary wall form mechanosensory units. The ubiquity of such units to modulate synaptic transmission is also supported by Piezo1 mRNA expressing pyramidal isocortical and thalamic neurons. This scenario suggests that ascending impulses to the cerebellar and cortical targets are presynaptically modulated by the reciprocal interaction with the mechanosensory pericapillary organ that ultimately modulates the vasomotor response.
An integrated LNA‐phase shifter in 65 nm CMOS for Ka‐band phased‐array receivers
Authors: Liu Haifeng , Guo Benqing , Han Yupeng , Wu Jingwei 
Published: November 2023

SummaryIn this paper, a vector‐sum phase shifter (VSPS) integrated with a wideband high‐gain low‐noise amplifier (LNA) for Ka‐band phased‐array receivers is presented. The digitally controlled VSPS based on the RF phase shifting architecture consists of a modified I/Q signal generator with additional inductor resonance and a programmable variable gain amplifier (VGA) based on Four 3 × 4 transistor arrays. Besides the reduced parasitic effect of the I/Q signal generator, an Equidistant Contraction Technology (ECT) is used in the VGA, to maintain higher phase shift accuracy of the VSPS. A multistage LNA with series inductor peaking is adopted to fulfill the flat wideband gain, where LC resonance networks are used as interstage matching to compensate for gain roll‐off at a higher frequency. Based on simulations in 65 nm CMOS technology, the presented LNA‐Phase shifter has achieved an average NF of 3.24–3.66 dB, and an average gain of 13.1–23.6 dB. Moreover, an RMS phase error of 1.1–12.6°, an RMS gain error of 4.2–5.6 dB, and an RMS magnitude error of 2.1–2.8 dB are maintained across 27–40 GHz, with a 360° phase shift coverage in steps of approximately 2.8125°. The chip consumes 16.83 mW from a 1.2 V supply voltage, and the occupied area is 0.65 mm2.
68Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity
Authors: Karpuz Merve , Ozgenc Emre , Oner Ezgi , Atlihan‐Gundogdu Evren , Burak Zeynep 
Published: November 2023

AbstractCancer is still a global health problem. Among cancer types, breast cancer is the most frequently diagnosed one, and it causes a high mortality rate if not diagnosed in the early stages. In our study, imatinib encapsulated, nanosized, neutral/cationic liposome formulations were prepared as theranostic agents for breast cancer. After the characterization studies in which all liposomes exhibited proper profile owing to their particle size between 133 and 250 nm, polydispersity index values lower than 0.4, neutral and cationic zeta potential values, and high drug encapsulation efficiency, controlled drug release behaviors with zero‐order kinetic were obtained. The higher than 90% radiolabeling efficiency values were obtained thanks to the determination of optimum radiolabeling condition (80°C temperature, 5 mCi radioactivity, and 10 min incubation period). According to the resazurin assay evaluating the cytotoxic profile of liposomes on MCF7 cells, neutral empty liposome was found as biocompatible, while both cationic liposomes (empty and drug‐loaded ones) exhibited high nonspecific cytotoxicity at even low drug concentration due to the existence of stearyl amine in the formulations. However, dose‐dependent cytotoxic effect and the highest cellular binding capacity were obtained by imatinib loaded neutral liposomes. In conclusion, 68Ga‐radiolabeled, imatinib‐loaded, neutral, nanosized liposome formulation is the most promising one as a theranostic agent among all formulations.
Sex‐specific cardiovascular protein levels and their link with clinical outcome in heart failure
Authors: de Bakker Marie , Loncq de Jong Mylène , Petersen Teun , de Lange Iris , Akkerhuis K. Martijn , Umans Victor A. , Rizopoulos Dimitris , Boersma Eric , Brugts Jasper J. , Kardys Isabella 
Published: November 2023

AbstractAimsThis study aims to provide insight into sex‐specific cardiovascular protein profiles and their associations with adverse outcomes, which may contribute to a better understanding of heart failure (HF) pathophysiology and the optimal use of circulating proteins for prognostication in women and men.Methods and resultsIn 250 stable patients with HF with reduced ejection fraction (HFrEF), we performed trimonthly blood sampling (median follow‐up: 26 [17–30] months). We selected all baseline samples and two samples closest to the primary endpoint (PEP; composite of cardiovascular death, heart transplantation, left ventricular assist device implantation, and HF hospitalization) or one sample closest to censoring and applied the Olink Cardiovascular III panel. We used linear regression to study sex‐based differences in baseline levels and joint models to study differences in the prognostic value of serially measured proteins. In 66 women and 184 men (mean age of 66 and 67 years, respectively), 21% and 28% reached the PEP, respectively. Mean baseline levels of fatty acid‐binding protein 4, secretoglobin family 3A member 2, paraoxonase 3, and trefoil factor 3 were higher in women (Pinteraction: 0.001, 0.007, 0.018, and 0.049, respectively), while matrix metalloproteinase‐3, interleukin 1 receptor‐like 1, and myoglobin were higher in men (Pinteraction: <0.001, 0.001, and 0.049, respectively), independent of clinical characteristics. No significant differences between sexes were observed in the longitudinal associations of proteins with the PEP. Only peptidoglycan recognition protein 1 showed a suggestive interaction with sex for the primary outcome (Pinteraction = 0.028), without multiple testing correction, and was more strongly associated with adverse outcome in women {hazard ratio [HR] 3.03 [95% confidence interval (CI), 1.42 to 6.68], P = 0.008} compared with men [HR 1.18 (95% CI, 0.84 to 1.66), P = 0.347].ConclusionsAlthough multiple cardiovascular‐related proteins show sex differences at baseline, temporal associations with the adverse outcome do not differ between women and men with HFrEF.
Time‐domain heart rate variability features for automatic congestive heart failure prediction
Authors: Moses Jeban Chandir , Adibi Sasan , Angelova Maia , Islam Sheikh Mohammed Shariful 
Published: November 2023

AbstractAimsHeart failure is a serious condition that often goes undiagnosed in primary care due to the lack of reliable diagnostic tools and the similarity of its symptoms with other diseases. Non‐invasive monitoring of heart rate variability (HRV), which reflects the activity of the autonomic nervous system, could offer a novel and accurate way to detect and manage heart failure patients. This study aimed to assess the feasibility of using machine learning techniques on HRV data as a non‐invasive biomarker to classify healthy adults and those with heart failure.Methods and resultsWe used digitized electrocardiogram recordings from 54 adults with normal sinus rhythm and 44 adults categorized into New York Heart Association classes 1, 2, and 3, suffering from congestive heart failure. All recordings were sourced from the PhysioNet database. Following data pre‐processing, we performed time‐domain HRV analysis on all individual recordings, including root mean square of the successive difference in adjacent RR interval (RRi) (RMSSD), the standard deviation of RRi (SDNN, the NN stands for natural or sinus intervals), the standard deviation of the successive differences between successive RRi (SDSD), the number or percentage of RRi longer than 50 ms (NN50 and pNN50), and the average value of RRi [mean RR interval (mRRi)]. In our experimental classification performance evaluation, on the computed HRV parameters, we optimized hyperparameters and performed five‐fold cross‐validation using four machine learning classification algorithms: support vector machine, k‐nearest neighbour (KNN), naïve Bayes, and decision tree (DT). We evaluated the prediction accuracy of these models using performance criteria, namely, precision, recall, specificity, F1 score, and overall accuracy. For added insight, we also presented receiver operating characteristic (ROC) plots and area under the ROC curve (AUC) values. The overall best performance accuracy of 77% was achieved when KNN and DT were trained on computed HRV parameters with a 5 min time window. KNN obtained an AUC of 0.77, while DT attained 0.78. Additionally, in the classification of severe congestive heart failure, KNN and DT had the best accuracy of 91%, with KNN achieving an AUC of 0.88 and DT obtaining 0.92.ConclusionsThe results show that HRV can accurately predict severe congestive heart failure. The findings of this study could inform the use of machine learning approaches on non‐invasive HRV, to screen congestive heart failure individuals in primary care.
Examining the effect of polyurethane dressing containing silver particles on the rate of diabetic foot ulcer infection in hospitalized patients: A randomized control study
Authors: Hosseinpoor Saeideh , Kalroozi Fatemeh , Nezamzadeh Maryam , Pishgooie Seyed AmirHosein 
Published: November 2023

AbstractBackground and AimsOne of the new types of dressings is the polyurethane dressing containing silver particles. This study was designed to evaluate the effect of polyurethane dressing containing silver particles on the rate of diabetic foot ulcer infection in hospitalized patients in a military hospital.MethodsThis was a randomized clinical trial study on 48 patients with diabetic foot ulcers who were referred to the wound clinic of Shahid Dr. Chamran Hospital in 2022. The qualified samples were divided into two groups of silver polyurethane dressing and simple sterile dressing based on a randomization block method. The wounds of both groups of patients were initially cleaned with normal saline and in the first round of dressing, and a sample of tissue secretions was collected by the researcher using a sterile swab from the wounds of the patients on two occasions, superficially and deeply. The patients' wounds in the intervention group were dressed with polyurethane foam dressing containing silver particles, while the simple sterile routine dressing was used in the control group. The rate of infection and wound secretions were examined and recorded on the first, seventh, fourteenth, and twenty‐first days from the start of dressing in both groups. To collect data, the IDSA tool was used.ResultsThe rates of wound infection before the intervention showed no significant differences in the two groups (p = 0.242). However, these rates changed on the 7th, 14th, and 21st days after the intervention. Moreover, the infection rate was significantly lower in the polyurethane dressing group containing silver particles (p < 0.001 and F = 30.31).ConclusionsUsing polyurethane dressing was proven to be more effective in this study on the rate of diabetic ulcer infection in patients compared to the simple sterile dressing. Thus, nurses can use this dressing for faster treatment of diabetic foot ulcers infection.
Recent developments in three‐dimensional Zn metal anodes for battery applications
Authors: Chen Jianyu , Wang Yizhou , Tian Zhengnan , Zhao Jin , Ma Yanwen , Alshareef Husam N. 
Published: November 2023

AbstractAqueous zinc (Zn) ion batteries (AZIBs) are regarded as one of the promising candidates for next‐generation electrochemical energy storage systems due to their low cost, high safety, and environmental friendliness. However, the commercialization of AZIBs has been severely restricted by the growth of dendrite at the Zn metal anode. Tailoring the planar‐structured Zn anodes into three‐dimensional (3D) structures has proven to be an effective way to modulate the plating/stripping behavior of Zn anodes, resulting in the suppression of dendrite formation. This review provides an up‐to‐date review of 3D structured Zn metal anodes, including working principles, design, current status, and future prospects. We aim to give the readers a comprehensive understanding of 3D‐structured Zn anodes and their effective usage to enhance AZIB performance.
Quality audits of nuclear medicine practices in a middle‐income African setting
Authors: Lutaka Magdalena , Speelman Aladdin , Naidoo Subhadranalene , Hamunyela Roswita 
Published: November 2023

AbstractIntroductionThe International Atomic Energy Agency (IAEA) introduced a Quality Management Audits in Nuclear Medicine (QUANUM) programme, to improve nuclear medicine practice standards aligned with international standards through self‐assessments. The absence of quality management audits in nuclear medicine departments could potentially result in a compromise in the safety and quality of patient care. To date, there is no evidence that quality audits have been conducted in nuclear medicine departments of this middle‐income country. This quality audit, therefore, assessed conformance to the IAEA QUANUM programme in four nuclear medicine departments.MethodsThe study adopted a quantitative methodological exploratory approach. The IAEA QUANUM programme was used to audit nuclear medicine services' overall activity such as clinical practice, management, radiopharmacy, general and radiation safety, quality assurance, operations and services. The data was collected via document analysis in four nuclear medicine department identified as Sites A–D.ResultsOverall results showed that Site A conformed with 247 out of 370 (67%) counts and non‐conformed with 123 out of 370 (33%) counts whilst Site B conformed with 205 out of 342 (60%) counts and non‐conformed with 137 out of 342 counts (40%). Site C conformed with 259 out of 345 (75%) counts and non‐conformed with 86 out of 345 (25%) counts. Site D conformed with 166 out of 349 (48%) counts and non‐conformed with 183 out of 349 (52%) counts. The study yielded 125 overall recommendations.ConclusionsAll the sites demonstrated good compliance to international standards in radionuclide therapy. Site A complied poorly in strategies and policies, whilst Site B complied poorly in quality control of equipment. Site C showed poor compliance to human resource development and Site D showed aspects pertaining to administration and management as well as evaluation of quality systems.
p16/Ki67 dual stain triage versus cytology in primary human papillomavirus‐based cervical cancer screening with limited genotyping
Authors: Trzeszcz Martyna , Mazurec Maciej , Jach Robert , Mazurec Karolina , Kotkowska‐Szeps Izabela , Kania Magdalena , Wantuchowicz Mariola , Wasowska Jolanta , Duczek‐Polakiewicz Monika , Rozmus Patrycja , Streb Joanna , Halon Agnieszka 
Published: November 2023

AbstractThe introduction of primary human papillomavirus (HPV) cervical cancer screening requires the implementation of an appropriate triage strategy that will be effective in detecting high‐grade cervical disease without losing diagnostic specificity. From the 30.066 screening tests results, a total of 1086 with available high‐risk human papillomavirus (HRHPV) with limited genotyping, cytology, and p16/Ki67 dual‐stain were selected. Two triage strategies for primary HPV screening were analyzed retrospectively based on the study group. Performance characteristics for p16/Ki67 and cytology triage in the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and grade 3 or worse (CIN3+) were calculated, detected in colposcopic biopsy. In HPV16/18‐positive cases, primary HPV with p16/Ki67 triage was significantly more specific than cytology (53.1%/16.8% for CIN2+; p < 0.0001; 45.9%/17.0% for CIN3+; p < 0.0001), with yielded sensitivity (95.7%/84.8% for CIN2+; p = 0.0955; 100.0%/87.5% for CIN3+; p = 0.0832). In other HRHPV‐positive cases (N16/N18), p16/Ki67 triage was also significantly higher specific (51.3%/15.3% for CIN2+; p < 0.0001; 44.5%/16.5% for CIN3+; p < 0.0001), with sensitivity (92.3%/74.4% for CIN2+; p = 0.0522; 90.9%/81.8% for CIN3+; p = 0.5637). Diagnostic predictive values were significantly higher for p16/Ki67 triage with the highest PPV in HPV16/18‐positive cases for CIN2+ (45.4%; 95% confidence interval [CI]: 35.2–55.8; p < 0.0001) and very high NPV in all HPV‐positive cases regardless of detected genotype (96.3%–100.0%). The risk (1‐NPV) for CIN3+ in HRHPV16/18‐positive/p16/Ki67‐negative women was 0.0%. Superior diagnostic performance compared to cytology for detecting cervical cancer precursors indicates that p16/Ki67 dual‐immunostain may be a highly effective tool of triage in primary HPV screening with limited HPV 16/18 genotyping in secondary cervical cancer prevention.
Polypharmacy in atrial fibrillation: A prospective analysis of mortality and ischemic stroke using the Clinical Practice Research Datalink
Authors: Slater Natasha , White Simon , Frisher Martin 
Published: November 2023

AbstractBackgroundObservational studies of polypharmacy and the risk of death or stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings. By using propensity score matching (PSM) and Cox regression, this study aimed to determine whether polypharmacy (five to nine medicines) in the 3 months following AF diagnosis, is associated with an increased risk of death or ischemic stroke, compared to non‐polypharmacy (one to four medicines).MethodsA prospective cohort study using data from the Clinical Practice Research Datalink (2006–2019). Data from 23 629 individuals with AF were analyzed. Cox regression models were adjusted for age, gender, morbidities, obesity, alcohol, smoking, and wealth. In the PSM models, cases and controls with near identical health profiles were selected from the study pool. The risk of death and stroke were presented as hazard ratios (HRs) with 95% confidence intervals (CIs).Results68.9% (n = 16 271) of the participants had polypharmacy. PSM showed that polypharmacy was associated with an increased risk of death during follow‐up (HR 1.32; 95% CI: 1.19–1.47, p < .01), but not ischemic stroke (HR 0.84; 95% CI: 0.69–1.02, p = .08).ConclusionPolypharmacy was associated with an increased risk of death during follow‐up, but not ischemic stroke, in individuals with AF. The effects of comorbidity and other confounding factors were reduced by using PSM. This study focused on the overall medication burden; however, further research is needed to identify which specific medications in polypharmacy regimens increase the risk of mortality in AF. These findings could inform prescribing practices in the future.
Functionalization of rice husk‐derived mesoporous silica nanoparticles for targeted and imaging in cancer drug delivery
Authors: Chen Shiow‐Yi , Jian Jhih‐Yun , Lin Hsiu‐Mei 
Published: November 2023

AbstractBACKGROUNDRice, a pivotal global food staple, annually accumulates vast amounts of rice husks, resulting in substantial environmental impact. Exploiting the high silica content in rice husk, our research aimed to recycle this agricultural byproduct to synthesize mesoporous silica nanoparticles (rMSNs). These nanoparticles were further modified to evaluate their potential as effective carriers for cancer drug delivery.RESULTSrMSNs showed high biocompatibility, large surface area and porous structure as MSNs, making them excellent drug carriers. Further modifications were applied to rMSNs, such as the incorporation of the lanthanides europium and gadolinium into rMSNs, making them fluorescent and magnetic for detection and tracking using confocal fluorescence microscopy and magnetic resonance imaging. Additionally, folic acid and aptamer AS1411 were conjugated with rMSNs to enhance the targeting of cancer cells. HeLa cells exhibited higher uptake of camptothecin (CPT)‐loaded rMSNs compared to normal fibroblast cells (L929). The linkage of disulfide bonds to rMSNs also allowed CPT to be carried by rMSNs and released intracellularly in the presence of the abundant reducing agent glutathione. The validation of rMSNs in vitro and in vivo proved their practical feasibility.CONCLUSIONOur findings indicate that low‐cost rMSNs, derived from recycled agricultural waste, can replace highly valuable MSNs. Functionalized rMSNs exhibit promising capabilities in transporting clinical drugs to specific aberrant tissues and offering dual‐targeting and dual‐imaging functionalities for enhanced cancer therapy. © 2023 Society of Chemical Industry.