bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatocellular Carcinoma: An Analysis of the Expression Status of Stress Granules
Authors: Sun Qiu , Cheng Shuqin , Du Liming , Ren Qingshuai , Wang Bangmao 
Published: October 2023

Abstract
Hepatocellular carcinoma (HCC) is a commonly occurring cancer distinguished by a bleak prognosis. Stress particles can protect cancer cells from apoptosis. This investigation aimed to analyze the impacts of stress granule genes on overall survival(OS), survival time, and prognosis in HCC. The combined TCGA-LIHC, GSE25097, and GSE36376 datasets were utilized to obtain genetic and clinical information. Optimal hub gene numbers and corresponding coefficients were determined using the LASSO model approach, and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate COX regression, respectively. The clusterProfiler R package was utilized to conduct an enrichment analysis of differentially expressed genes (DEGs), which utilizes the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases to detect biological processes that exhibit significant enrichment. Protein-protein interaction networks (PPI) according to stress granule genes that show differential expression within the high-risk and low-risk groups in the combined datasets of TCGA-LIHC, and with the use of the STRING website, the GSE25097 and GSE36376 datasets were constructed, and the data obtained was analyzed and visualized using the Cytoscape software. The prognostic model's receiver operating characteristic (ROC) curve was produced and plotted utilizing the timeROC software package. Nomogram models were constructed to predict the outcomes at 1, 3, and 5-year overall survival(OS) prognostications with good prediction accuracy. We identified seven stress granule genes (DDX1、DKC1、BICC1、HNRNPUL1、CNOT6、DYRK3、CCDC124)having a prognostic significance and developed a risk score model. In accordance with the findings obtained from the ROC analysis, the risk score model was able to anticipate 1-, 3-accurately, and 5-year OS in individuals suffering from HCC. The findings of KM analysis indicated that the group with a high risk exhibited significantly reduced overall survival (OS) in comparison with those of the low-risk group(p < 0.001). The nomogram model's findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC cohort. GO and Gene Set EnrichmentAnalysis(GSEA) analysis suggested that these stress granules might be involved in the cell cycle, RNA editing, and other biological processes. Based on the impact of stress granule genes on HCC prognosis, it is possible that in the future, it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.
High-dimensional single-cell analysis identifies cellular signatures associated with response to vedolizumab therapy in ulcerative colitis
Authors: Festen Eleonora , Sun Shiqiang , Pibiri Paola , Karmi Naomi , Oelen Roy , de Jong Sofie , Bangma Amber , Teunis Johan , Kats-Ugurlu Gursah , Paraskevopoulou Maria , Farahmand Saman , Juarez Julius , Bleck Bertram , Xia Guliang , Visschedijk Marijn , Faber Klaas , Hermoso Marcela , Weersma Rinse , Bigaeva Emilia 
Published: October 2023

Abstract
Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the gastrointestinal tract. When conventional therapy fails, patients need biologics such as vedolizumab (VDZ) to manage the disease. While VDZ has shown a compelling efficacy in UC, the rate of primary non-response amounts up to 50%. To uncover cellular and molecular cues that coordinate VDZ (non-)response, we performed single-cell transcriptomics and high-dimensional immunoprofiling of gut mucosal and peripheral blood cells obtained from 25 UC patients before and 14 weeks after the initiation of VDZ therapy. We show that VDZ non-response is not driven by integrins beyond the VDZ-targeted α4β7 that may carry on the influx of leukocytes to the inflamed gut mucosa. Instead, non-response is marked by a distinct cellular signature of highly abundant innate immune cells, which is clearly detectable before the start of VDZ treatment. We furthermore highlight the aberrant functional state of inflammatory monocytes and regulatory T cells in non-responders, which together with inflammatory fibroblasts form a rewired cell-to-cell communication network. This prospective longitudinal study reveals that mucosal inflammatory mechanisms are fundamentally different between responders and non-responders to VDZ, which provides deeper insights and new opportunities for improvement of UC treatment.
Microplastics in Antarctica - a Plastic Legacy in the Antarctic Snow?
Authors: Jones-Williams Kirstie , Primpke Sebastian , Galloway Tamara , Rowlands Emily , Cole Matthew , Waluda Claire , Manno Clara 
Published: October 2023

Abstract

Microplastic pollution in remote inland Antarctica is largely unknown. This study explored the plastic footprint of snow from remote Antarctic camps; Union Glacier, Schanz Glacier and the South Pole. Refined automated FTIR techniques enabled interrogation of <25 µm microplastics and fibres in Antarctic snow for the first time. Microplastics were pervasive (73 - 3,099 MP L-1). The majority (95%) measured <50 µm, indicating that previous microplastic reports in Antarctica may be underestimated, due to analytical restrictions. Polymer composition and concentration did not vary significantly between sites, with dominant polymers being polyamide (PA), polyethylene terephthalate (PET), polyethylene (PE) and synthetic rubbers, likely from both local (clothing, ropes, flags) and long-range (aerially deposited) sources. Results indicate that even in the most remote regions of earth, humans are leaving a plastic legacy in the snow, and illustrate the importance of remote, cryospheric regions as critical study sites for determining temporal fluxes in microplastic pollution.
Early Color Photometry of the Type Iax Supernova 2023mnc: Inferring the Distance and Progenitor Constraints
Authors: Yang Thomas , Zhang Maureen , Shen Tianran , Jiang Justin , Faison Michael , Warrener Michael , Zheng Tai 
Published: October 2023

Abstract
Early-time radioactive signals from type Ia supernovae (SNeIa) can provide important constraints on the explosion mechanism and the progenitor system. We present observations and analysis of SN2023mnc, a SN Ia, ∼ 7 days following its discovery. Follow-up observations were conducted in opticalbands, covering phases from ∼ −4 days to ∼ 15 days relative to its g-band peak luminosity. The early photometry allows us to estimate the physical properties of the ejecta and characterize the possible divergence from a normal SN Ia; we were able to characterize it as a Type Iax supernova instead. The estimated date of explosion is t0 = 60130 MJD and implies a short rise time of trise ≈ 16 days. The apparent g-band peak magnitude and the post-peak decline rate are mmax(g) = −19.52 ± 0.47mag and ∆m15(g) = −0.825 ± 1.635 mag, respectively. Based on the light curve fitting of standard SN Ia models, the distance modulus is predicted to be 37.98 ± 0.207 mag for g band measurements, and the SN is predicted to be 394.46 ± 38 Mpc from Earth. Assuming a 56Ni powered radiativediffusion, the estimated bolometric light-curve peaks at 1.08ergs−1 and indicates that only 0.05M⊙ of 56Ni was produced, making SN 2023mnc a moderate luminosity object in the Iax class with peak absolute magnitude of MV = −16.4 mag. Comparing the observed color evolution with the predictedby different models such as deflagration-to-detonation transition and pure-deflagration scenario, the latter one is favored. The photometry of SN 2023mnc offers a unique opportunity to examine the progenitor systems and ignition process of the SNe Iax, adding weight to the population study of such sub-class SNe.
Mechanical and thermal properties of beef tallow/rice husk charcoal-based plaster for building applications
Authors: Astika I Made , Suprapta Winaya I Nyoman , Ary Subagia I Dewa Gede , Wirawan I Ketut Gede 
Published: October 2023

The construction industry represents the largest energy-consuming sector globally, primarily due to its substantial operational processes power demand. To address this, there has been an increased emphasis on using materials capable of absorbing and storing heat as alternative energy storage in buildings. Phase Change Materials (PCMs) demonstrate this capability, harnessing the latent heat principle to absorb surplus heat energy and subsequently release it in times of deficiency. This study examines the mechanical and thermal properties of wall cladding materials integrated with PCMs, specifically beef tallow and rice husk charcoal. These composites were produced via direct incorporation, with rice husk charcoal weight fractions of 8, 10, and 12 %. This approach resulted in weight fractions of 28, 30, and 32 % in the plaster layer material. Fourier Transform Infrared Spectroscopy (FTIR) tests confirmed the PCM composite's chemical compatibility across all its components, with the composite morphology appearing as microcapsules. In terms of thermal conductivity, the addition of rice husk charcoal to beef tallow enhanced the PCM composite's performance. This enhancement indicated that approximately 10 % of rice husk charcoal weight fraction could be successfully incorporated into the plaster layer material without leakage. At an ambient temperature of 45 °C, a plaster composite with 30 wt. % PCM met the standard compressive strength for plaster coating. Furthermore, it was found that this composite could reduce the temperature by 2.4 °C. The results concluded that beef-tallow PCM exhibits promising potential as a heat storage system for buildings, contributing to energy conservation in the construction industry
Study of fiber detachment dynamics from the seeds by the baffle element
Authors: Veliev Fazil 
Published: October 2023

The issue of the safety of cotton seeds during the roller ginning process is one of the subjects of research on the dynamic processes of primary processing of raw materials.
The study of the work of roller gins first of all showed that the process of roller ginning is based on the interaction of raw cotton, a working roller, a knife, and a breaking organ. This is a component that ensures, at certain interaction, the separation of fiber from the seeds. At the same time, there are probably no physical foundations that could determine the spatial orientation of these four components of the ginning process.
In the process of roller ginning in the initial position, the seed is drawn to the slot of the contact gap of the knife-drum due to the tension of the fibers in the contact. Subsequently, the seed is struck with a certain impulse. The separation of the fibers from the seed after the impact of the beater occurs sequentially, not simultaneously.
As a result of theoretical and experimental studies, the optimum frequency of shock pulse on the seed (f=18−20) was found to be the most technologically successful in terms of providing the best quality indicators of seeds and fibers. Beating in the resonance mode allows reducing the magnitude of the shock impulse on the seed leading to the reducing degree of damage to the seeds. It is believed that in the initial position, the seeds are drawn to the slit of the contact gap of the knife-drum machine due to the tension of the fibers in the contact. At this moment, the seeds at the end of the strand move only under the action of an elastic restoring force. The active part of the fiber bundle section in a dynamic process can be as little as 0.001 or less.
The average value of the compliance coefficient for the raw cotton variety BA-440 was determined experimentally. This allows determining the stiffness coefficient of the volatiles indirectly.
According to the obtained parameters, the dynamic state of the system practically falls into the region of parametric resonance, where the motion is unstable. This means that the seeds at the end of the strand increase significantly after the impact of the beater, which leads to the separation of the seeds from the fibers
CAR-T Therapy in Relapsed Refractory Multiple Myeloma
Authors: Ding Hong , Wu Yu 
Published: October 2023

abstract:
Multiple myeloma is a plasma cell neoplasm. The emergence of proteasome
inhibitors, immunomodulatory drugs, and anti-CD38 monoclonal antibodies has improved
the prognosis of multiple myeloma patients. However, some patients are still
insensitive to conventional therapy or frequently relapse after remission. Chemotherapy
based on proteasome inhibitors or immunomodulatory drugs is ineffective in controlling
the progression of relapsed refractory multiple myeloma. No consensus has been
reached on treating relapsed refractory multiple myeloma to date. Recently chimeric antigen
receptor T cells therapy has shown promising results that could achieve rapid remissions
of patients and improve their prognoses. Additionally, most patients in chimeric
antigen receptor T cell clinical trials were triple-refractory multiple myeloma patients, indicating
that chimeric antigen receptor T cell immunotherapy could overcome drug resistance
to new drugs. Since single immunotherapies are prone to acquired resistance, combination
immunotherapies based on emerging immunotherapies may solve this issue.
Achieving complete remission and minimal residual disease negative status as soon as
possible is beneficial to patients. This paper reviewed the main chimeric antigen receptor
T cell products in relapsed refractory multiple myeloma, and it explained the drug resistance
mechanism and improvement methods of chimeric antigen receptor T cells therapy.
This review summarized the best beneficiaries of chimeric antigen receptor T cell
therapy and the salvage treatment of disease recurrence after chimeric antigen receptor
T cell therapy, providing some ideas for the clinical application of chimeric antigen receptor
T cells.
Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis
through the SIX1/HBO1 Pathway against Oxygen and Glucose
Deprivation Injury in Human Umbilical Vein Endothelial Cells
Authors: Zhang Xiangyu , Zhang Xin , Chen Lu , Zhao Jiaqi , Raj Ashok , Wang Yanping , Li Shulin , Zhang Chi , Yang Jing , Sun Dong 
Published: October 2023

Background:
Angiogenesis and energy metabolism mediated by adipose mesenchymal
stem cell-derived exosomes (AMSC-exos) are promising therapeutics for vascular diseases.

Objectives:
The current study aimed to explore whether AMSC-exos have therapeutic effects on
oxygen and glucose deprivation (OGD) human umbilical vein endothelial cells (HUVECs) injury
by modulating the SIX1/HBO1 signaling pathway to upregulate endothelial cells (E.C.s) glycolysis
and angiogenesis

Methods:
Methods: AMSC-exos were isolated and characterized following standard protocols. AMSC-exos
cytoprotective effects were evaluated in the HUVECs-OGD model. The proliferation, migration,
and tube formation abilities of HUVECs were assessed. The glycolysis level was evaluated by detecting
lactate production and ATP synthesis. The expressions of HK2, PKM2, VEGF, HIF-1α,
SIX1, and HBO1 were determined by western blotting, and finally, the SIX1 overexpression vector
or small interfering RNA (siRNA) was transfected into HUVECs to assess the change in
HBO1 expression.

Results:
Our study revealed that AMSC-exos promotes E.C.s survival after OGD, reducing E.C.s
apoptosis while strengthening E.C.'s angiogenic ability. AMSC-exos enhanced glycolysis and reduced
OGD-induced ECs injury by modulation of the SIX1/HBO1 signaling pathway, which is a
novel anti-endothelial cell injury role of AMSC-exos that regulates glycolysis via activating the
SIX1/HBO1 signaling pathway.

Conclusion:
The current study findings demonstrate a useful angiogenic therapeutic strategy for
AMSC-exos treatment in vascular injury, thus providing new therapeutic ideas for treating
ischaemic diseases.
The Cracked Potential of Boron-containing Compounds in Alzheimer’s
Disease
Authors: Soriano-Ursúa Marvin Antonio , Farfán-García Eunice Dalet 
Published: October 2023

Abstract:
Alzheimer’s disease (AD) is a relevant neurodegenerative disease worldwide. Its relevancy is mainly due to its high prevalence and high global burden. Metalloids have attracted attention as
their serum levels seem to differ between affected patients and healthy individuals. On the other
hand, atoms of some metalloids have been included in bioactive molecules, exerting some interesting
effects, mainly due to their ameliorative effects in neurodegeneration. In this sense, boron-containing
compounds (BCC) have been explored to regulate or prevent neurodegeneration. As an example,
boric acid has been reported as a compound with antioxidant, anti-inflammatory and neurotrophic
effects. Other natural BCCs have also shown amelioration of metabolic conditions often related to
increased risk of neurodegenerative maladies. However, in recent years, additional organoboron
compounds have been reported as active in several processes linked to neurodegeneration and especially attractive as regulators of the origin and progression of AD. In this mini-review, some data are
collected suggesting that some natural BCC could be used as preventive agents, but also the potential
of some BODIPYs as tools for diagnosis and some other BCC (particularly boronic acids and pinacol boronic esters) for acting as promising therapeutic agents for AD.
Inclusive Library Leadership
Authors: Johnson Elizabeth "Nikki" , Copeland Andrea , Palmer Kristi , Sutton Charles 
Published: October 2023

Alumni of the 2008 Indiana’s Librarians Leading in Diversity (ILLID) Fellowship Program will participate in focus groups to provide insight into the longitudinal impact of the program on their academic and professional experiences. Preliminary discussions with ILLID fellows surfaced both high and low program points, many aligning with the challenges identified in the 2017 IMLS Forum Report, Positioning Library and Information Science Graduate Programs for 21st Century Practice. Fellows expressed that the cohort experience and mentorship were key to their development and success as library and information science professionals. Several fellows expressed while they attained a full-time professional position, the library work cultures were not wholly conducive to work satisfaction or personal well-being. The ILLID program focused on successful attainment of the MLIS degree and a professional position. It did not however address the climate of the library environments into which the new professionals would enter. The focus group findings (along with other inputs) will inform the creation of a next generation diversity initiative one that connects recruitment and retention, one that will build a bridge between learning and working environments. We hope to learn and share from the focus groups the impact of the original program on the fellows and how that impact influenced the profession. The knowledge we gain from the fellows’ last 15 years of experiences in libraries has the potential to contribute to improving learning environments and curriculum within LIS programs, to developing inclusive leadership approaches, and to promoting work cultures where diverse individuals can thrive.
Multiple Means of Engagement
Authors: Saunders Laura , Wong Melissa 
Published: October 2023

Universal Design for Learning (UDL) offers instructors a framework “to improve and optimize teaching and learning for all people based on scientific insights into how humans learn” (CAST, 2018). The framework consists of three principles: Multiple Means of Engagement, Multiple Means of Representation, and Multiple Means of Action and Expression. This session will take a deep dive into the principle of Multiple Means of Engagement and help attendees think deeply about how to implement that principle in their courses in concrete ways. However, rather than functioning as a traditional panel of experts providing knowledge to an audience, this session will model the practices of Multiple Means of Engagement by emphasizing interactive discussions and activities throughout the session.
The principle of Multiple Means of Engagement is concerned with learner motivation, and centers mainly on the “why” or the reasons behind the instructional choices we make that can help to engage and motivate learners. This principle recognizes that different learners have different motivations for learning as well as different barriers that can impede that learning (CAST, 2018). Indeed, the same factors that might excite and motivate one learner could be off-putting for another. In order to engage the largest number of learners, the principle of Multiple Means of Engagement encourages instructors to provide learners with autonomy and choices, highlight the relevance of the instruction, vary demands and challenges, foster collaboration and community, and promote self-regulation including self-assessment.
The panelists, who both have a strong grounding in pedagogy and instructional design, including the principles of UDL, will provide a framing introduction to UDL and Multiple Means of Engagement, as described in more detail below.
This session will begin with a brief introduction to UDL and the three principles that make up the framework. From there, the panelists will offer a more thorough examination of the principle of Multiple Means of Engagement. They will review each of the guidelines and checkpoints involved in the principle as well as the theories that underpin them. Further, while the UDL framework is modality agnostic, teaching modalities such as face-to-face and online synchronous and asynchronous each present unique opportunities and challenges with regard to learner engagement and motivation. The panelists will draw on the research and their own experience teaching across modalities to discuss these specific issues. Throughout the framing portion of the session, they will provide concrete examples of the principle of Multiple Means of Engagement in action.
Following this framing presentation, the panelists will model the principles of Multiple Means of Engagement by involving attendees in interactive discussions and activities. Attendees will have an opportunity to share ideas and in collaboration with others, develop strategies for building Multiple Means of Engagement in their own courses.