bluuebunny/crossref_metadata_2025_split huggingface dataset:
Level of Awareness and Challenges in Republic Act 9184 Procurement Procedures: A Basis for Training and Internal Policy Development
Authors: Dagohoy Abigail Marie V. , Salvatierra Armelyn C. , Constantino Ma. Lourdes L. , Matudan Nhorvic M. , Malang Bernandino 
Published: January 2024

ABSTRACT

End-users, who act as the origin of all procurement requests, are responsible for providing technical specifications, scope of work, and terms of reference, conducting a market survey, recommending the Approved Budget for the Contract (ABC), providing technical advice, assisting in the preparation of bidding documents, and attending all stages of the procurement. This study aims to evaluate two essential aspects related to the execution of procurement activities: the level of knowledge and understanding among end-users and the difficulties they encounter while conducting procurement activities.
This research used a mixed-methods approach, involving surveys and interviews, to collect data about the awareness levels and difficulties encountered by the participants regarding RA 9184 procurement procedures. In research, "mixed method" refers to a methodology that combines qualitative and quantitative techniques in a single study to gain a more comprehensive understanding of a research issue by harnessing the advantages of both data types.
The survey assessed respondents' knowledge of various procurement processes, revealing that they generally have good awareness. Procurement planning was well understood, while document preparation and electronic procurement had slightly lower but still decent awareness levels. Statistical analysis, including Pearson correlation and p-values, showed that awareness was significantly related to years of service in certain procurement aspects but not in post-qualification and awards. Respondents reported occasional difficulties, with the majority having no major issues. However, challenges in areas like canvassing, market study, and document preparation were identified, indicating the need for adjustments or assistance. Other difficulties included a lack of training, technical specification preparation, supplier availability, and failed bidding.
In conclusion, policymakers should implement clear procurement request guidelines following RA 9184. These guidelines should specify procedures and required documents, reducing delays and inefficiencies and saving time and resources. Additionally, issuing agency memoranda designating specific End-Users fosters coordination. It serves as a direct point of contact with the BAC Secretariat, ensuring informed Project Management Officers (PMOs) have access to guidance and support. The establishment of a dedicated committee for updating End-Users on specifications and providing annual GPPB-recognized training, which ensures alignment with changing requirements, market conditions, and legal compliance, enhancing procurement efficiency and expertise, should also be imposed.
Exploring the School Heads Working Condition in Supporting Communities of Practice (CoP) and Technical Assistance (TA) to Teachers: A Multiple Case Study
Authors: Catedral1 Rey R. , Datulayta Rene G. , Lawan Pilot B. , Lumbu-an Jenevieve D. , Carbon Rechiel B. 
Published: January 2024

This study explored the school heads’ working conditions in supporting Communities of Practice and Technical Assistance to teachers as vehicles to address problems in the teaching and learning processes and promote learning and collaboration within organizations. A qualitative research design employing multiple case study methods was utilized. The study included one (1) Principal-in-Charge (PIC), three (3) school heads, and three (3) master teacher positions. A total of seven (7) participants participated in this study. Moreover, the study employed semi-structured interview guide questions. The data were analyzed using Colizzi's thematic analysis.
The results showed that the working conditions supporting the communities of practice and technical assistance to teachers are classroom observation, learning action cell, In-Service Training (InSeT), and conference and urgency. The following working conditions may affect or influence school heads and master teachers in supporting communities of practice and technical assistance to teachers: intellectance (openness to new experiences), communication channels, schedules, lack of leadership, and knowledge of technical assistance providers. Participants experienced challenges, motivations, fulfillment, and positivity in implementing CoPs and TAs. The following themes were coded on the influence of experiences on communities of practice and technical assistance to teachers: positivity, flexibility, thriving, social support and interaction, and positivity.
The openness to new experiences, such as a sense of curiosity, open-mindedness, and acceptance of novel experiences, is needed for CoPs and TAs to prosper in school. Communication channels should be clear and appropriate to their audience, allow deeper conversations, and exchange ideas, thoughts, opinions, knowledge, and data in CoP and TA should be understood with clarity and purpose. School leaders must be empowered with managerial and leadership skills to support and influence communities of practice and technical assistance to teachers.
Toward a Convivial Design
Authors: Franzato Carlo 
Published: January 2024

Abstract
This article is inspired by the work of Ivan Illich, especially Tools for Conviviality, which critiques industrialization and elaborates Illich's proposal for conviviality and is a major influence on post-development theory. In the early 1970s, Illich anticipated issues that design begins to explore only at the end of the twentieth century. This article discusses what he anticipated and develops this into practical suggestions for the evolution of design. Above all, the article provides suggestions for two intertwined design fields: design for sustainability and codesign. An analysis of Illich's work allows for the identification of three methodological movements acting toward a convivial design: (1) conduct a critique of the status quo, (2) imagine alternative proposals, and (3) carefully qualify the ethos of alternatives.
Service Design as Formgiving: Breaking Free from the Marketing-Dominant Logic
Authors: Secomandi Fernando 
Published: January 2024

Abstract
This article presents a critique of Vargo and Lusch's service-dominant logic (SD Logic) and proposes an alternative basis for service design. The proposed approach builds upon the formgiving tradition outlined in Maldonado's definition of industrial design. More specifically, the article questions SD Logic's neglect of service materiality and emphasizes the need for a deliberate reevaluation of formgiving, taking into account the unique materiality of services exchanged in face-to-face interactions.
Medication Treatment for Youth in Substance Use Disorder Residential Treatment
Authors: Yule Amy M. , Mail Victoria , Butler Rebecca , Wilens Timothy E. 
Published: January 2024

Objective: Residential is a common treatment setting for youth with high-severity substance use disorders (SUD). This study evaluated the prevalence of psychiatric symptoms and medication for youth in residential SUD treatment. Methods: Youth in Massachusetts state licensed and funded SUD residential programs completed questionnaires assessing demographics, primary substance of use, and psychopathology symptoms (Youth Self Report [YSR]/Adult Self Report [ASR]). De-identified medication lists were provided by the programs. Descriptive statistics were used to describe the sample. Results: Among the 47 youth who participated, 51.1% were male, 72.3% white, 83% non-Hispanic, mean age 20.7 years. Opioids were the most common primary substance identified by youth (51.1%), and 75% had at least one clinically elevated subscale on the YSR/ASR. Most youth were prescribed at least one medication (89.4%) with a mean of 2.9 medications. Conclusion: Youth in SUD residential treatment frequently have clinically elevated psychiatric symptoms, and psychotropic medication was commonly prescribed.
Preschool-level socio-economic deprivation in relation to emotional and behavioural problems among preschool children in Sweden
Authors: Durbeej Natalie , Ssegonja Richard , Salari Raziye , Dahlberg Anton , Fabian Helena , Sarkadi Anna 
Published: January 2024

Aims: The aim of this study was to explore the association between preschool-level socio-economic deprivation and emotional and behavioural problems among preschool children in Sweden using a multilevel approach. Methods: In this cross-sectional study, we used data on 2267 children whose parents and preschool teachers had responded to items measuring individual-level socio-economic deprivation and the Strengths and Difficulties Questionnaire (SDQ) for assessment of emotional and behavioural problems. Further, the Socioeconomic Structure Compensation Index (SSCI), collected from Uppsala municipality, was used to assess preschool-level socio-economic deprivation. Unadjusted and adjusted multilevel logistic regression models were used to explore the relations between preschool-level socio-economic deprivation and emotional and behavioural problems. Results: In unadjusted models, children who attended preschools classified as highly deprived had elevated odds for emotional symptoms (odds ratio (OR) 1.71) as rated by parents. However, this association did not remain significant after adjusting for individual-level socio-economic deprivation factors. In both unadjusted and adjusted models, children who attended preschools classified as moderately deprived had elevated odds for peer-relationship problems as rated by parents (OR 1.63; adjusted OR 1.48). There were no significant associations between preschool deprivation and emotional and behavioural problems as rated by preschool teachers. Conclusions: Swedish preschools may have a compensatory capacity in addressing children’s emotional and behavioural problems, whereas preschool-level deprivation remained significantly associated with peer-relationship problems after controlling for individual-level socio-economic deprivation factors. This implies that peer-relationship problems in deprived preschools need to be addressed in a broader community context.
Do hospital data breaches affect health information technology investment?
Authors: Lee Jinhyung , Kim Hyeyeong , Choi Sung J 
Published: January 2024

ObjectivesData breaches are a financial and operational threat to hospitals. In this study, we examine the association between a data breach and information technology capital and labor investment.MethodsIn this retrospective cohort study, we used American Hospital Association data from 2017 to 2019 and an unbalanced panel of hospitals with 6751 unique hospital-year observations. The breached group had 482 hospital-years, and the control group had 6269 hospital-years. We estimated the association between data breaches, information technology capital, and labor investment using the average treatment effect with propensity-score matching.ResultsFrom 2017 to 2019, hospitals experienced more hacking and information technology incidents but fewer thefts and losses. We found that hospital data breaches were associated with a 66% increase in employed information technology staff and a 57% increase in outsourced information technology staff. Breaches were not associated with information technology operating expenses and information technology capital expenses.ConclusionHigher information technology labor investment due to the remediation of data breaches is an added cost to the healthcare system. Hospitals and policymakers should consider initiatives to improve cybersecurity and protect patient data.
A multicenter study of posttransplantation low-dose inotuzumab ozogamicin to prevent relapse of acute lymphoblastic leukemia
Authors: Metheny Leland L. , Sobecks Ronald , Cho Christina , Fu Pingfu , Margevicius Seunghee , Wang Jiasheng , Ciarrone Lisa , Kopp Shelby , Convents Robin D. , Majhail Navneet , Caimi Paolo F. , Otegbeye Folashade , Cooper Brenda W. , Gallogly Molly , Malek Ehsan , Tomlinson Benjamin , Gerds Aaron T. , Hamilton Betty , Giralt Sergio , Perales Miguel-Angel , de Lima Marcos 
Published: January 2024

Abstract
The curative potential of allogeneic hematopoietic transplantation (allo-HCT) in patients with acute lymphoblastic leukemia (ALL) is hampered by relapse. Inotuzumab ozogamicin (INO) is an anti-CD22 monoclonal antibody bound to calicheamicin, which has significant activity against ALL. We hypothesized that low-dose INO would be safe and feasible after allo-HCT. Therefore, we conducted a phase 1 study to determine the dose and safety in this setting. Patients were eligible if they were aged 16 to 75 years, had undergone allo-HCT for CD22+ ALL, were in complete remission (CR) after allo-HCT, had high risk of recurrence, were between day 40 and 100 after allo-HCT with adequate graft function, and did not have a history of sinusoidal obstruction syndrome (SOS). The objectives of this trial were to define INO maximum tolerated dose (MTD), to determine post–allo-HCT INO safety, and to measure 1-year progression-free survival (PFS). The trial design followed a “3+3” model. The treatment consisted of INO given on day 1 of 28-day cycles. Dose levels were 0.3 mg/m2, 0.4 mg/m2, 0.5 mg/m2, and 0.6 mg/m2. Median age was 44 years (range, 17-66 years; n = 18). Disease status at transplantation was first CR (n = 14) or second CR or beyond (n = 4). Preparative regimen was of reduced intensity in 72% of patients who received transplantation. Most common toxicity was thrombocytopenia. There were no instances of SOS; the MTD was 0.6 mg/m2. One-year nonrelapse mortality was 5.6%. With a median follow-up of 18.1 months (range, 8.6-59 months) 1-year post–allo-HCT PFS and overall survival is 89% and 94%, respectively. Low-dose INO has a favorable safety profile and was associated with high rates of 1-year PFS. This trial was registered at www.clinicaltrials.gov as #NCT03104491.
Nonlinear Impact Damage Evolution of Charpy Type and Analysis of Its Key Influencing Factors
Authors: Mao Jianfeng , Xu Qian , Yang Jiadong , Cao Chi , Wang Dasheng , Zhong Fengping , Chen Mingya 
Published: January 2024

AbstractThe current research of Charpy impact mainly focuses on obtaining the ductile brittle transition temperature of materials by experiments. Compared with experiments, numerical simulation can study many problems with harsh conditions. However, there are still few studies on the influence of geometric factors such as side grooves. In this paper, the geometry of standard Charpy impact test is designed. Specimens with different widths and side grooves are tested. The finite element model of Charpy impact was established by ABAQUS software. Use test results and simulation results to verify each other. The effects of sample width, side groove depth and side groove bottom fillet on the impact fracture resistance of the sample were studied. The results show that the specimen width is positively correlated with the impact toughness of the specimen. The side groove greatly reduces the impact toughness of the material; the toughness of side groove decreases with the increase of depth; the fracture toughness of side groove decreases with the increase of fillet at the bottom of side groove. The proportion of toughness energy to impact energy of samples was analyzed. The results show that the toughness energy accounts for about 70% of the impact energy of the sample, which has little to do with the geometric characteristics of the sample. This study presents a reliable method for studying Charpy impact tests. The influence of geometric parameters is obtained, which provides a reference method for the study of impact toughness of high toughness materials.
Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis
Authors: Fang Xinyu , Ao Xiang , Xiao Dandan , Wang Yu , Jia Yi , Wang Peiyan , Li Mengyang , Wang Jianxun 
Published: January 2024

Abstract
Background
Circular RNAs are enriched in cardiac tissue and play important roles in the pathogenesis of heart diseases. In this study, we aimed to investigate the regulatory mechanism of a conserved heart-enriched circRNA, circPan3, in cardiac hypertrophy.

Methods
Cardiac hypertrophy was induced by isoproterenol. The progression of cardiomyocyte hypertrophy was assessed by sarcomere organization staining, cell surface area measurement, and expression levels of cardiac hypertrophy markers. RNA interactions were detected by RNA pull-down assays, and methylated RNA immunoprecipitation was used to detect m6A level.

Results
The expression of circPan3 was downregulated in an isoproterenol-induced cardiac hypertrophy model. Forced expression of circPan3 attenuated cardiomyocyte hypertrophy, while inhibition of circPan3 aggravated cardiomyocyte hypertrophy. Mechanistically, circPan3 was an endogenous sponge of miR-320-3p without affecting miR-320-3p levels. It elevated the expression of HSP20 by endogenously interacting with miR-320-3p. In addition, circPan3 was N6-methylated. Stimulation by isoproterenol downregulated the m6A eraser ALKBH5, resulting in N6-methylation and destabilization of circPan3.

Conclusions
Our research is the first to report that circPan3 has an antihypertrophic effect in cardiomyocytes and revealed a novel circPan3-modulated signalling pathway involved in cardiac hypertrophy. CircPan3 inhibits cardiac hypertrophy by targeting the miR-320-3p/HSP20 axis and is regulated by ALKBH5-mediated N6-methylation. This pathway could provide potential therapeutic targets for cardiac hypertrophy.

Graphical Abstract
The regulatory relationship between transcription factor STAT3 and noncoding RNA
Authors: Liu Siyi , Li Wentao , Liang Lin , Zhou Yanhong , Li Yanling 
Published: January 2024

AbstractSignal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance. STAT3 is considered a potential subtarget for tumor therapy. Noncoding RNA (ncRNA) is a special type of RNA transcript. Transforming from “junk” transcripts into key molecules involved in cell apoptosis, growth, and functional regulation, ncRNA has been proven to be closely related to various epithelial–mesenchymal transition and drug resistance processes in tumor cells over the past few decades. Research on the relationship between transcription factor STAT3 and ncRNAs has attracted increased attention. To date, existing reviews have mainly focused on the regulation by ncRNAs on the transcription factor STAT3; there has been no review of the regulation by STAT3 on ncRNAs. However, understanding the regulation of ncRNAs by STAT3 and its mechanism is important to comprehensively understand the mutual regulatory relationship between STAT3 and ncRNAs. Therefore, in this review, we summarize the regulation by transcription factor STAT3 on long noncoding RNA, microRNA, and circular RNA and its possible mechanisms. In addition, we provide an update on research progress on the regulation of STAT3 by ncRNAs. This will provide a new perspective to comprehensively understand the regulatory relationship between transcription factor STAT3 and ncRNAs, as well as targeting STAT3 or ncRNAs to treat diseases such as tumors.
Identification of NADPH Oxidase Genes Crucial for Rice Multiple Disease Resistance and Yield Traits
Authors: Zhu Yong , Su Hao , Liu Xin-Xian , Sun Ji-Fen , Xiang Ling , Liu Yan-Jing , Hu Zhang-Wei , Xiong Xiao-Yu , Yang Xue-Mei , Bhutto Sadam Hussain , Li Guo-Bang , Peng Yuan-Ying , Wang He , Shen Xu , Zhao Zhi-Xue , Zhang Ji-Wei , Huang Yan-Yan , Fan Jing , Wang Wen-Ming , Li Yan 
Published: January 2024

AbstractReactive oxygen species (ROS) act as a group of signaling molecules in rice functioning in regulation of development and stress responses. Respiratory burst oxidase homologues (Rbohs) are key enzymes in generation of ROS. However, the role of the nine Rboh family members was not fully understood in rice multiple disease resistance and yield traits. In this study, we constructed mutants of each Rboh genes and detected their requirement in rice multiple disease resistance and yield traits. Our results revealed that mutations of five Rboh genes (RbohA, RbohB, RbohE, RbohH, and RbohI) lead to compromised rice blast disease resistance in a disease nursery and lab conditions; mutations of five Rbohs (RbohA, RbohB, RbohC, RbohE, and RbohH) result in suppressed rice sheath blight resistance in a disease nursery and lab conditions; mutations of six Rbohs (RbohA, RbohB, RbohC, RbohE, RbohH and RbohI) lead to decreased rice leaf blight resistance in a paddy yard and ROS production induced by PAMPs and pathogen. Moreover, all Rboh genes participate in the regulation of rice yield traits, for all rboh mutants display one or more compromised yield traits, such as panicle number, grain number per panicle, seed setting rate, and grain weight, resulting in reduced yield per plant except rbohb and rbohf. Our results identified the Rboh family members involved in the regulation of rice resistance against multiple pathogens that caused the most serious diseases worldwide and provide theoretical supporting for breeding application of these Rbohs to coordinate rice disease resistance and yield traits.
A two-sequence motif-based method for the inventory of gene families in fragmented and poorly annotated genome sequences
Authors: Nørrevang Anton Frisgaard , Shabala Sergey , Palmgren Michael 
Published: January 2024

AbstractDatabases of genome sequences are growing exponentially, but, in some cases, assembly is incomplete and genes are poorly annotated. For evolutionary studies, it is important to identify all members of a given gene family in a genome. We developed a method for identifying most, if not all, members of a gene family from raw genomes in which assembly is of low quality, using the P-type ATPase superfamily as an example. The method is based on the translation of an entire genome in all six reading frames and the co-occurrence of two family-specific sequence motifs that are in close proximity to each other. To test the method’s usability, we first used it to identify P-type ATPase members in the high-quality annotated genome of barley (Hordeum vulgare). Subsequently, after successfully identifying plasma membrane H+-ATPase family members (P3A ATPases) in various plant genomes of varying quality, we tested the hypothesis that the number of P3A ATPases correlates with the ability of the plant to tolerate saline conditions. In 19 genomes of glycophytes and halophytes, the total number of P3A ATPase genes was found to vary from 7 to 22, but no significant difference was found between the two groups. The method successfully identified P-type ATPase family members in raw genomes that are poorly assembled.