bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction of Economic and Legal Measures for the Development of the Ecologization System at an Enterprise
Authors: Dzhancharov Turmushbek , Rozanova Tatiana , Pasternak Svetlana , Dmitrieva Olga , Romanova Anastasia , Lebedev Konstantin 
Published: September 2023

Objective: The study analyzes economic and legal approaches to the development of the ecologization system at an enterprise. The authors seek to substantiate the importance of integrating environmental practices into the legal framework and promoting sustainable development in business operations. A clear relationship between the use of ecologization systems and the profitability of companies in the long term has been already shown in world practice.

Method: The research is based on systematic and integrated approaches combined with a set of general and special scientific methods.

Results: The article discusses possible solutions for the ecologization of a company's activities, considering the forecasting of environmental costs in the process of strategic planning of activities, as well as the implementation of investment and innovation projects.

Conclusions: The results emphasize the crucial role of the regulatory framework in the introduction of sustainable methods of ecologization in enterprises. It is concluded that the integration of sustainability principles into the legal system enhances environmental protection and supports long-term economic viability. Enterprises that give priority to sustainable development not only comply with legal obligations but also gain a competitive advantage, meeting the expectations of society and contributing to the achievement of sustainable development goals.
Clinical presentation, evaluation, and management of patients with myasthenia gravis at a tertiary care center in Pakistan
Authors: Sonawalla Aziz , Shafaq Saleem  , Allana Salim , Rabia Qaiser  , Rohma Shamsi  
Published: September 2023

Note: The editors of PJNS are aware that this article contains old data. However, we have decided to publish this article because a) the data is still important as there is paucity of data in this regard from Pakistan, and b) the authors have written the article well and have mentioned this limitation of their manuscript.
Background and objectives:
Little is known about the clinical profile and outcome of myasthenia gravis in Pakistan. The objective of this study is to review the clinical characteristics of patients with myasthenia gravis in Pakistan, and the outcome of investigations and treatment.
Methods:
The study comprised a retrospective review of charts of patients diagnosed with myasthenia gravis at Aga Khan University Hospital in Karachi, Pakistan, over a period of 16 years from 1987 to 2003. The following features were reviewed: (i) clinical presentation, (ii) investigations especially nerve conduction studies, acetylcholine receptor antibodies, and imaging studies of the thorax, (iii) treatments administered (including thymectomy). Data analysis was done using Excel sheets.
Results:
Of the 83 patients, 51(61.4%) were males, whereas 32 (38.6%) were females. The age range was from 12 to 81 years, mean age of 43.7 years (SD± 18.2). In the 60 years plus group, there were three times as many males as compared to females. Limb weakness was noted in 58 (69.9%), ocular symptoms in 57(68.7%), and oropharyngeal symptoms in 54(65.1%) patients. Three (3.6%) presented in a state of myasthenic crisis. Tensilon test was performed in 34 patients and was positive in 31(91.2%), repetitive nerve conduction studies (RNS) were performed in 37 patients and was positive in 26(70.3%), acetylcholine receptor antibodies were done in 60 patients, and were positive in 55(91.7%). Thymic enlargement was seen in 28 out of 43 patients who underwent CT-Scan/MRI studies of the thorax. Besides pyridostigmine, most patients received immunosuppressive therapy with either steroids or azathioprine or both. The thymectomy was performed in 44 patients.
Conclusion:
The general disease pattern of MG, as noted in our series, appears to follow a similar pattern as noted worldwide. However, this retrospective and hospital-based study has its limitations, and more prospective and epidemiological studies are needed.
MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN RỐI LOẠN GIẤC NGỦ Ở BỆNH NHÂN CAO TUỔI TĂNG HUYẾT ÁP ĐIỀU TRỊ TẠI BỆNH VIỆN LÃO KHOA TRUNG ƯƠNG
Authors: Nguyễn Thị Hoa , Đỗ Thị Thư , Trần Thị Hoà 
Published: September 2023

Mục tiêu: Phân tích một số yếu tố liên quan đến rối loạn giấc ngủ (RLGN) ở bệnh nhân (BN) cao tuổi tăng huyết áp (THA). Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, sử dụng bộ câu hỏi đánh giá chất lượng giấc ngủ (Pittsburgh Sleep Quality Index - PSQI) trên 95 BN cao tuổi THA điều trị nội trú và ngoại trú tại Bệnh viện Lão khoa Trung ương từ tháng 01/2023 - 4/2023, được khảo sát về chất lượng giấc ngủ. Kết quả: Phần lớn BN được khảo sát có RLGN, chiếm 80%. BN có tuổi cao hơn, thời gian mắc THA lâu hơn, có nhiều bệnh đồng diễn hơn và có tính cách hay lo âu có tỷ lệ mắc RLGN cao hơn so với nhóm còn lại, sự khác biệt này có ý nghĩa thống kê (p < 0,05). Kết luận: Tỷ lệ BN có RLGN chiếm 80%. Một số yếu tố có thể dẫn đến tỷ lệ RLGN cao hơn ở BN THA gồm: Tuổi cao, thời gian mắc THA dài, có nhiều bệnh đồng nhiễm và có tính cách hay lo nghĩ.
PRE-CLINICAL RESEARCH ON THE APPLICATION OF CAR-T THERAPY IN THE TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA
Authors: Hồ Viết Hoành , Nghiem Thi Minh Chau , Can Van Mao , Ngo Thu Hang , Bui Khac Cuong 
Published: September 2023

Objectives: To create chimeric antigen receptor (CAR) T cells and evaluate the effect on CD19+ B cells in animal models of acute lymphoblastic leukemia. Methods: An experimental research (In vitro and In vivo) was conducted at the Department of Pathophysiology, Military Medical University, from June 2019 to 2022. Results: Successfully transformed and created CAR-T cells by nucleofection technology; the survival rate of cells after transformation was 48.9 - 60.7%. The expression of CAR molecules on the T cell surface after 21 and 28 days of culture were 66.23% and 97.34%, respectively. CAR-T cells could proliferate vigorously when co-cultured with cancer cells carrying CD19+, and the ability to lyse cancer cells carrying CD19+ after 6 and 24 hours (lysis efficiency was 24.8 - 71.8%, respectively); this ability increased with the proportion of CAR-T cells present in the medium and with the time of co-culture. CAR-T cell block restricted the proliferation of CD19+ cancer cells (through Luciferase activity), prolonged the survival time, and increased the survival rate of the murine model of acute lymphoblastic leukemia. Conclusion: CAR-T cells can grow when co-cultured with CD19 receptor-expressing cells and CD19+ cancer cell lysis. The excellent effect when using generated CAR-T cells to treat a mouse model of acute leukemia was assessed by Luciferase activity associated with CD19+ cancer cells, survival time, and mouse weight.
HUBUNGAN JARAK DENGAN CAKUPAN DETEKSI DINI HEPATITIS B PADA IBU HAMIL DI PUSKESMAS MATRAMAN, TAHUN 2018
Authors: Lasut Doni , Elsi Elsa , Hananto Miko , Sulastri Rani 
Published: September 2023

Abstract
Background : Hepatitis as an infectious disease and silent infection needs to be taken seriously, therefore the Directorate General of Hepatitis-PISP Sub Directorate of P2P conducts early detection of pregnant women as a risk group so that it does not transmit to the mother’s baby.
Objective : This study is a review of studies based on surveillance data conducted at the time of early detection of hepatitis B in pregnant women in the Matraman District Health Center during January 2018 to October 2018.Method : This study uses DDHB surveillance data at the Matraman District Health Center. The analysis was carried out with correlation coverage with the average distance and abstracted with the closest distance analysisResults : The results of early detection of HBsAg reactive pregnant women obtained 32 pregnant women (2.71%) reactive from 1180 pregnant women who followed DDHB. Based on the distribution of pregnant women coverage in the region varies if the spatial analysis approach is done by calculating the flat distance as confounding which is assessed and found to be more distant urban areas from the location of the Matraman District Health Center, the fewer pregnant women who check their pregnancy.Conclusion : Distance related to the coverage of DDHB in the Matraman District Health Center. This situation needs a more adequate surveillance system Keywords : Jarak, Hepattitis B, DDHB, HBsAg

Abstrak
Latar Belakang : Hepatitis sebagai penyakit menular dan bersifat silent infection karenanya perlu ditangai secara serius, oleh karena itu Subdit Hepatitis-PISP Dirjen P2P melakukan deteksi dini hepatitis B (DDHB) pada ibu hamil sebagai kelompok beresiko sehingga tidak menularkan ke bayi yang dikandungnya.
Tujuan : Penelitian mendapatkan hubungan jarak terhadap cakupan DDHB bumil di Puskesmas Kecamatan Matraman selama Bulan Januari 2018 hingga Oktober 2018.
Metode : Penelitian ini menggunakan data survailans DDHB Puskesmas Kecamatan Matraman. Analisis dilakukan dengan mendapatkan nilai korelasi di antara keduanya..
Hasil : Hasil deteksi dini ibu hamil reaktif HbsAg didapatkan sebanyak 32 ibu hamil (2,71 %) reaktif dari 1180 ibu hamil yang mengikuti DDHB. Berdasarkan distribusi cakupan ibu hamil di wilayah tersebut bervariasi apabila dilakukan pendekatan analisis spasial dengan penghitungan jarak datar didapatkan semakin jauh wilayah kelurahan dari lokasi Puskesmas Kecamatan Matraman maka akan semakin sedikit ibu hamil yang memeriksakan kehamilannya.
Kesimpulan : Jarak berhubungan terhadap cakupan DDHB di Puskesmas Kecamatan Matraman. Keadaan ini perlunya sistem survilans yang lebih memadai

Kata Kunci : Jarak, Hepattitis B, DDHB, HBsAg
من مباحث أصول الفقه الإسلامي النهي، تعريفه وصيغته
Authors: أبو ناجي عبد السلام محمود 
Published: September 2023

يعني المنع يقال: نهاه عن كذا أي منعه عنه. ومنه العقل نهية؛ لأنه ينهى صاحبه عن الوقوع فيما يخالف الصواب، ويمنعه عنه . وهو - بهذا ـ يكون ضد الأمر. جاء في القاموس المحيط - بشرحه تاج العروس ج 10 ص 380 - 381 ما نصه : (نهاه ينهاه نهيا. ضد أمر. فانتهى وتناهى كف. أنشد سيبويه لزيادة بن زيد العذري :
إذا ما انتهى علمي تناهيت عنده *** أطال فأملى أو تناهى فأقـصـرا
وفي الصحاح : نهيته عن كذا فانتهى عنه وتناهي: (أي كف) هـ. وإلى نفس هذا المعنى ذهب ابن منظور في كتابه: لسان العرب ج 2 ص 218 فانظره، وانظر مختار الصحاح ص 708. والنهي نوعان : نفسي، وهو طلب كف عن فعل لا بقول : كف ونحوه كدع وذر. ولفظي ويقصد به ذلك اللفظ المركب من : نون مفتوحة وهاء ساكنة وياء، فهو لفظ ومدلوله ألفاظ وهي صيغ النهي. والمعني في هذا البحث هو النهي اللفظ لأنه هو الذي يتعلق به غرض الأصوليين باعتباره يبحث عن الدلالة اللفظية السمعية، ولأنه هو الذي تترتب عليه أحكام شرعية. والحديث عن النفسي إنما هو من باب استيفاء الأقسام، والتمييز بين الماهيتين.
أداء القيادات الإدارية وأثرها على فاعلية القرارات الإدارية في المؤسسات المصرفية
Authors: بن مسعود محمود محمد 
Published: September 2023

تهدف هذه الدراسة الى تحقيق فاعلية المصارف ونموها وتقدمها والتعرف إلى أثر أداء القيادات الإدارية على فاعلية اتخاد القرارات الإدارية في المصارف التجارية في المنطقة الوسطى. والتعرف إلى مستوى فاعلية عملية اتخاذ القرار الإدارية بالمصارف التجارية بالمنطقة الوسطى. و كذلك إلى تحديد مدى وجود فروق ذات دلالة إحصائية في اتجاهات المديرين ومعاونيهم حول ممارسة عملية اتخاد القرارات الإدارية تعزى للمتغيرات الديمغرافية والوظيفة المتمثلة في( العمر، المستوى التعليمي، سنوات الخبرة). واستخدم الباحث منهج التحليل الوصفي كما استخدم صحيفة الاستبانة كأداة لجمع المعلومات، وقد توصلت الدراسة إلى أن مجتمع البحث ذكوري أغلبهم يحملون مؤهلات جامعية وأعمارهم وخبرتهم متناسبة ومناسبة للقيادة الإدارية إلا أنه تنقصهم الدورات التدريبية في مجال إدارة الفروع المصرفية ومجال اتخاذ القرارات الإدارية وتوصلت إلى وجود أثر إيجابي ذي دلالة إحصائية لتمتع مديري فروع البنوك محل البحث بالمهارات الإدارية على فاعلية القرارات الإدارية بتلك المصارف. و تميز مديري فروع البنوك محل البحث بالإبداع الإداري يؤثر على فاعلية القرارات الإدارية بتلك المصارف. تمتع مديري فروع البنوك محل البحث بالقيادة المنفتحة يؤثر إيجاباً على فاعلية القرارات الإدارية بتلك المصارف. تدني أداء القيادات الإدارية لمديري فروع البنوك محل البحث يؤثر بقوة على فاعلية القرارات الإدارية بتلك المصارف.
Interventions for Improving Mental Health and Quality of Life of Older Adults with Mental Illness in Long-term Care: A Systematic Review and Meta-analysis
Authors: Ngamwongwiwat Benjawan , Kongsuwan Vineekarn , Songwathana Praneed 
Published: September 2023

Various mental health interventions have been provided to older adults living in long-term care facilities, but the overall effectiveness of these interventions in improving mental health and quality of life remains inconclusive. This study is the first systematic review and meta-analysis to investigate and report interventions’ effects on improving mental health and quality of life among this population. A comprehensive search was conducted from January to February 2022 using PubMed, CINAHL, ProQuest, Web of Science, and Cochrane databases to identify eligible intervention studies published in English from December 2011 to December 2021. The inclusion criteria required studies to measure mental health and quality of life as outcomes in individuals aged 60 years and older with mental illness living in long-term care facilities. Studies that measured only mental health or quality of life were excluded. The PRISMA guidelines were used to guide the study’s method and report. Two reviewers independently evaluated the included studies’ methodological quality and extracted data. A third reviewer resolved discrepancies.
Six randomized controlled trials and two quasi-experimental studies were included for systematic review, of which five studies qualified for meta-analysis involving 658 participants. Due to high heterogeneity, subgroup analysis with a fixed effects model was conducted. The interventions integrating active social interactions reduced depressive symptoms (low certainty of the evidence). Additionally, reminiscence-based interventions improved the quality of life of older adults with mental illness (low certainty of evidence). Although the effectiveness of interventions remains inconclusive due to high heterogeneity, a limited number of studies in the meta-analysis, and low-quality evidence, this review suggested that nursing care and activities promoting active social interactions and reminiscence should be implemented in living in long-term care facilities to enhance the quality of life and mental health of older adults with mental illness. However, the types and components of interventions should be adjusted based on available resources and contextual factors. Further research with larger sample sizes and higher methodological quality is warranted to strengthen the evidence base in this area.
Effects of the Family Empowerment Program on Medication Adherence and Treatment Success Among Adults with Pulmonary Tuberculosis: A Randomized Controlled Trial
Authors: Khakhong Saowaluck , Lirtmunlikaporn Sumalee , Unahalekhaka Akeau , Wichaikhum Orn-anong 
Published: September 2023

Unsuccessful treatment of pulmonary tuberculosis results from medication non-adherence. Family is a significant source of support for adults with pulmonary tuberculosis but has limited ability to continuously support in the first six months of treatments. This randomized controlled trial, a two-arm post-test-only design was utilized to investigate the effects of the family empowerment program on medication adherence and treatment success among adults with pulmonary tuberculosis. The sample comprised 64 family members caring for newly diagnosed adults with pulmonary tuberculosis who visited a tuberculosis clinic of a university hospital in central Thailand. The participants were assigned randomly to either the experimental arm (n = 32) to receive the program or the control arm (n = 32) to receive only usual care. Data were collected using the Demographic and Pulmonary Tuberculosis-related Characteristic Data Collection Form, Family Member’s Demographic Characteristic Data Collection Form, Tuberculosis Medication Adherence Scale, and criteria to identify tuberculosis treatment success of the World Health Organization. Data were analyzed using descriptive statistics, Pearson’s chi-square, Fisher’s Exact, and McNemar tests. The results showed that the experimental arm had significantly higher medication adherence at the 3rd and 19th weeks after the program ended than the control arm. The experimental arm had a significantly higher treatment success rate at the 19th week thanthe control arm. The family empowerment program was effective in improving medication adherence and treatment success. Nurses need to be trained to empower family members in providing continuous support for adults with pulmonary tuberculosis. To fully assess the program’s effectiveness, additional research is required to investigate its performance in different contexts and with various samples.
UTILIZACIÓN DE YOGUR BOVINO COMO ADITIVO EN EL ENSILAJE DE MAÍZ (ZEA MAYS) EN ASOCIACIÓN CON FRIJOL (PHASEOLUS VULGARIS).
Authors: Villegas Oria Miguel Ignacio 
Published: September 2023

La utilización del yogur bovino como aditivo en el ensilaje de maíz (Zea mays) en asociación con frijol (Phaseolus vulgaris), fueron analizados a los días 21, 42 y 63 posterior al ensilado. Cada silo peso 2 kg; existieron 3 tratamientos: (TI) 100 % maíz, (TII) maíz 75 % y frijol 25 %; (TIII) maíz 50 % y frijol 50 %. El ANOVA fue con medidas repetidas en el tiempo. El olor, color, textura, humedad, temperatura: El TI tuvo diferencia significativa (DF) con respecto al TII y TIII por todo el experimento, la categoría que predomino fue de excelente calidad. El Ph, %H, %MS, no tuvieron DF entre tratamientos T1 y T2, mientras que T3 se comportó superior. A diferencia el %Ce, %M.O y %PC existió DF entre todos los tratamientos, evidenciando aumento significativo en el contenido nutritivos (p<0,05). El rendimiento de maíz 6 kg/mtrs2 y hectárea de 60.000 kg y el frijol 0,9 kg/mts y hectárea de 9.000 kg. El costo unitario del TI: 0,002 $/kg, TII: 0,006 $/kg; Mientras que T III: 0,02 $/kg.
PREVALENCIA DE SÍNTOMAS RESPIRATORIOS Y FACTORES DE RIESGO EN UNA EXTRUSORA DE ALUMINIO EN ECUADOR
Authors: Molina Delgado José Renán , Salcedo Noroña Darwin Raúl , Navarrete Arboleda Edmundo Daniel 
Published: September 2023

Este estudio investigó la prevalencia de síntomas respiratorios en trabajadores de la industria del aluminio en Ecuador. Se analizó a 200 trabajadores de una planta de extrusión de aluminio, recopilando información sobre síntomas como sibilancias, asma y bronquitis crónica. Los resultados mostraron una prevalencia del 9,1% de sibilancias y del 6,0% de asma, siendo más frecuentes en los trabajadores de extrusión. Además, alrededor del 21,2% de los trabajadores informaron síntomas respiratorios relacionados con el trabajo y cerca del 10% tuvo que cambiar de puesto debido a estos síntomas.
Los trabajadores de extrusión tienen mayor riesgo de desarrollar asma y cambiar de puesto de trabajo. El tabaquismo se relaciona con el asma, la bronquitis crónica y los síntomas respiratorios relacionados con el trabajo. Este estudio destaca la importancia de abordar los riesgos ocupacionales para la salud respiratoria en la industria del aluminio, enfatizando la necesidad de medidas preventivas y de protección.
VANTAGENS E DESVANTAGENS DA UTILIZAÇÃO DA FIBRA DE VIDRO NO CONCRETO ARMADO: UMA REVISAO BIBLIOGRAFICA
Authors: Vieira De Souza Bruna , Mendes da Silva Jonathan , Bentes Moreira Karla Cristina , Carvalho Lopes Shara 
Published: September 2023

A construção civil busca constantemente materiais inovadores para aprimorar a resistência e durabilidade das estruturas. O concreto armado, amplamente utilizado, tem sido alvo de estudos quanto à deterioração e surgimento de manifestações patológicas. Nesse contexto, a fibra de vidro surge como uma alternativa para substituir o aço, oferecendo propriedades mecânicas favoráveis, como alta resistência à tração e corrosão, leveza e neutralidade eletromagnética.
No entanto, o uso da fibra de vidro em estruturas de grande porte e sob altas solicitações ainda requer mais estudos e testes experimentais para garantir sua segurança e eficiência. Em comparação ao aço, as armaduras de fibra de vidro apresentam vantagens, como alta resistência à corrosão, fadiga e fogo. No entanto, possuem desvantagens como estabilidade dimensional e demanda por mão de obra especializada.
O objetivo deste trabalho é realizar uma revisão bibliográfica para comparar as características e propriedades da fibra de vidro e do aço no concreto armado, destacando suas vantagens e desvantagens. A metodologia utilizada incluiu a busca por informações atualizadas em livros, artigos científicos e teses, com análise qualitativa dos dados coletados. Os resultados apontaram que a utilização da fibra de vidro na construção civil, pode sim ser vantajosa em relação a algumas construções, como construções em ambientes agressivos e corrosivos, mas como qualquer material tem suas desvantagens, o polímero reforçado com fibra de vidro (PRFV) não seria diferente, podendo ter sua utilização limitada a certas situações e exposições.
La responsabilidad de los estados en casos de violencia de género.
Authors: Wilson Emma , Thompson Oliver 
Published: September 2023

La violencia de género es un problema social complejo y multidimensional que afecta a millones de mujeres en todo el mundo, incluyendo América Latina. La responsabilidad de los Estados en casos de violencia de género es un tema de gran relevancia y actualidad, que ha sido abordado por numerosos autores en los últimos años. En este trabajo de revisión se realizó una búsqueda sistemática de la literatura en bases de datos como Scopus, Scielo y Latindex, con el objetivo de identificar los principales hallazgos y conclusiones de los estudios realizados en América Latina sobre la responsabilidad de los Estados en casos de violencia de género. Se seleccionaron un total de 20 artículos de revisión y 10 artículos originales que abordaron diferentes aspectos de la violencia de género en la región. Entre los principales hallazgos se encontraron los factores de riesgo asociados a la violencia doméstica en mujeres brasileñas, las barreras en el acceso a la justicia para las mujeres víctimas de violencia de género en Colombia, la necesidad de abordar la dimensión de género de las violaciones a los derechos humanos cometidas durante la dictadura en Chile, los desafíos en la implementación de políticas públicas para la atención a la violencia de género en México, y la importancia de ampliar la perspectiva de la producción académica sobre violencia de género en el Cono Sur. Estos hallazgos pueden ser de gran utilidad para diseñar y evaluar políticas públicas y acciones que contribuyan a prevenir y erradicar la violencia de género en América Latina, promoviendo el respeto y la equidad de género como valores fundamentales para la construcción de una sociedad más justa y democrática.