bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic value of an age-adjusted BIG score in adult patients with traumatic brain injury
Authors: Bai Xue , Wang Ruoran , Zhang Cuomaoji , Wen Dingke , Ma Lu , He Min 
Published: November 2023

BackgroundThe base deficit, international normalized ratio, and Glasgow Coma Scale (BIG) score was previously developed to predict the outcomes of pediatric trauma patients. We designed this study to explore and improve the prognostic value of the BIG score in adult patients with traumatic brain injury (TBI).MethodsAdult patients diagnosed with TBI in a public critical care database were included in this observational study. The BIG score was calculated based on the Glasgow Coma Scale (GCS), the international normalized ratio (INR), and the base deficit. Logistic regression analysis was performed to confirm the association between the BIG score and the outcome of included patients. Receiver operating characteristic (ROC) curves were drawn to evaluate the prognostic value of the BIG score and novel constructed models.ResultsIn total, 1,034 TBI patients were included in this study with a mortality of 22.8%. Non-survivors had higher BIG scores than survivors (p &lt; 0.001). The results of multivariable logistic regression analysis showed that age (p &lt; 0.001), pulse oxygen saturation (SpO2) (p = 0.032), glucose (p = 0.015), hemoglobin (p = 0.047), BIG score (p &lt; 0.001), subarachnoid hemorrhage (p = 0.013), and intracerebral hematoma (p = 0.001) were associated with in-hospital mortality of included patients. The AUC (area under the ROC curves) of the BIG score was 0.669, which was not as high as in previous pediatric trauma cohorts. However, combining the BIG score with age increased the AUC to 0.764. The prognostic model composed of significant factors including BIG had the highest AUC of 0.786.ConclusionThe age-adjusted BIG score is superior to the original BIG score in predicting mortality of adult TBI patients. The prognostic model incorporating the BIG score is beneficial for clinicians, aiding them in making early triage and treatment decisions in adult TBI patients.
The role of primed and non-primed MSC-derived conditioned media in neuroregeneration
Authors: Hudakova Nikola , Mudronova Dagmar , Marcincakova Dana , Slovinska Lucia , Majerova Petra , Maloveska Marcela , Petrouskova Patricia , Humenik Filip , Cizkova Dasa 
Published: November 2023

IntroductionWith growing significance in nervous system repair, mesenchymal stem cell-derived conditioned media (MSCCM) have been used in cell-free therapies in regenerative medicine. However, the immunomodulatory and neuroregenerative effects of MSCCM and the influence of priming on these effects are still poorly understood.MethodsIn this study, by various methods focused on cell viability, proliferation, neuron-like differentiation, neurite outgrowth, cell migration and regrowth, we demonstrated that MSCCM derived from adipose tissue (AT-MSCCM) and amniotic membrane (AM-MSCCM) had different effects on SH-SY5Y cells.Results and discussionAT-MSCCM was found to have a higher proliferative capacity and the ability to impact neurite outgrowth during differentiation, while AM-MSCCM showed more pronounced immunomodulatory activity, migration, and re-growth of SH-SY5Y cells in the scratch model. Furthermore, priming of MSC with pro-inflammatory cytokine (IFN-γ) resulted in different proteomic profiles of conditioned media from both sources, which had the highest effect on SH-SY5Y proliferation and neurite outgrowth in terms of the length of neurites (pAT-MSCCM) compared to the control group (DMEM). Altogether, our results highlight the potential of primed and non-primed MSCCM as a therapeutic tool for neurodegenerative diseases, although some differences must be considered.
Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide
Authors: Slabe Zala , Balesar Rawien A. , Verwer Ronald W. H. , Drevenšek Gorazd , Swaab Dick F. 
Published: November 2023

IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on polymorphisms in PACAP and PAC1 indicate a relationship of the PACAP system with schizophrenia (SCZ).MethodsThe prefrontal cortex was chosen to measure PACAP-gene related expression changes, since this is a central structure in the symptoms of schizophrenia (SCZ). We investigated alterations in the expression of the PACAP-related genes by qPCR in the human dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) of 35 SCZ patients and 34 matched controls in relation to SCZ, suicide, gender and medication.ResultsThe ACC revealed an upregulation in PACAP, PAC1, VPAC1 and VPAC2 in SCZ suicide (S) completers compared to controls. An increase in PACAP, VPAC1 and VPAC2 expression was also present in the ACC in SCZ-S compared to SCZ patients who died naturally (SCZ-N). In the DLPFC, an increase in PAC1 was found in SCZ-N patients compared to SCZ-S and controls. Moreover, an increase in all PACAP-related genes was present in SCZ-N male patients compared to SCZ-N females. Concluding, expression changes were found in PACAP-related genes in relation to SCZ, suicide and gender. In particular, there was a higher PACAP-related gene expression in SCZ patients in the ACC in relation to suicide and in DLPFC in relation to SCZ.DiscussionThese findings suggest a potential link between PACAP and the pathophysiology of SCZ and suicide. Further research is needed to understand the functional significance and potential clinical applications of these changes.
Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty
Authors: Hu Wenhao , Song Ziyi , Shang Houlai , Wang Jingcheng , Hao Yuedong 
Published: November 2023

ObjectivesThis study intended to explore whether albumin-associated inflammatory and nutritional markers could predict post-operative delirium (POD) in older patients after total hip arthroplasty (THA). In addition, we established a nomogram model for POD prediction.MethodsTotally, 254 elderly cases who received THA were included. Clinical and laboratory data of these patients were retrospectively collected. Albumin-associated inflammatory and nutritional markers included neutrophil-to-albumin ratio (NAR), CRP-to-albumin ratio (CAR), prognostic nutritional index (PNI), and systemic inflammation score (SIS). The LASSO, univariate and multivariate logistic regression analyses were utilized to screen risk factors. A nomogram model was developed according to the results of multivariate regression analyses.ResultsAmong 254 patients, 49 cases had POD with an incidence of 19.3%. LASSO regression and multivariate logistic analyses suggested that preoperative NAR, preoperative PNI, preoperative SIS, and age &gt;75 years were risk factors for POD. A nomogram model was developed according to the results of multivariate logistic analyses. The calibration curve suggested that the predicted probability of this nomogram model was in good line with the actual probability. The DCA showed that this nomogram model had net benefits for the prediction of POD for elderly patients following THA.ConclusionAlbumin-associated inflammatory and nutritional markers including NAR, PNI, and SIS could predict POD in elderly patients following THA.
Assessment of dietary nitrate supplementation: prevalence of use, knowledge, attitudes and beliefs among active Australians
Authors: McMahon Nicholas F. , Brooker Paige G. , Pavey Toby , Leveritt Michael D. 
Published: November 2023

IntroductionUse of nitrate as a dietary supplement has gained popularity among athletes and recreationally active individuals to enhance exercise performance. However, the prevalence and patterns of use, and knowledge of nitrate as a dietary supplement are unknown.MethodsIndividuals (≥16y) completed a 42-item online questionnaire to collect (i) sociodemographic information; (ii) participation in activity and sport; (iii) nitrate supplementation use and reasons; (iv) attitudes and beliefs regarding information sources and the safety of nitrate as a dietary supplement; and (v) knowledge of dietary nitrate supplements.ResultsIn total, 1,404 active adults (66% female) took part in the study. Only about one in 10 respondents (11.9%) reported they had consumed dietary nitrate (“users”) in the past, most commonly as beetroot juice (31.3%). Over two-thirds (69.4%) of users could not correctly identify the correct timing of intake relative to performance time to best improve exercise performance, and most users (82.3%) were unsure of the contraindications to oral consumption of dietary nitrate supplements. Only 3.9% of users experienced adverse effects after ingesting dietary nitrate supplements. Among non-users, the most common reasons respondents selected for not using dietary nitrate supplements were “I do not think I need to” (70.2%) and “I have never thought about it” (69.2%).DiscussionThere is evidence to support the efficacy of dietary nitrate intake in improving exercise performance. However, findings from this study suggest dietary nitrate is under-utilized. Educational messages that target dietary nitrate consumption should be targeted toward nutritionists, coaches, and exercise physiologists to bridge the gap between knowledge-to-practice.
Effect of Heartfulness meditation program on perceived stress and satisfaction with life of female students
Authors: Gupta Pradeep K , Malhotra Neetu , Goel Preeti , Thimmapuram Jayaram , Krishna Prasanna 
Published: November 2023

Though literacy levels are slowly improving in India due to the steps taken by the Government of India, it has been a challenge for female students with gender disparities in literacy levels. Stress levels are high in students, more so during their exam times. While prior literature has demonstrated the prevalence of stress during student life, there is limited evidence of any interventions to decrease stress and improve satisfaction with life, specifically for female students. Heartfulness meditation is a heart-based meditation practice that may reduce stress and improve satisfaction with life among female students. We conducted a prospective cohort analysis comparing perceived stress and satisfaction with life outcomes among female students who self-selected to participate in the Heartfulness meditation program. The first group, G20, underwent intervention from week 0 until week 12 and continued their practice independently until week 20. The second group, G14, joined the intervention from week 7 until week 12 with only a 6-week exposure to guided meditation sessions through Heartfulness Trainers. They continued their practice independently until week 20. Data on Perceived Stress (PSS) and Satisfaction with Life (SWLS) were collected at week 0 and week 20 for both groups. G20 had 127 participants, and G14 had 113 participants. Ninety-four participants from the G20 group and 93 from G14 completed the study. The G20 group showed a statistically significant reduction of PSS scores from 20.79 to 18.96, and an increase in the SWLS scores from 22.03 to 23.51 from baseline to the end of the study period. The study of the Pearson correlation coefficient indicated that there is a weak positive correlation between pre- and post-scores for both the groups for both PSS and SWLS. Our findings suggest that Heartfulness meditation practice offers significant benefits with perceived stress and satisfaction with life among female students independent of their age. Still, a prolonged guided intervention of over 6 weeks is needed. A larger, randomized study with an additional control group with no meditation intervention is recommended.Clinical trial registrationISRCTN11302156, https://doi.org/10.1186/ISRCTN11302156.
Un besoin de spécialisation de plus en plus poussée. Interview de Mme Assathiany, Directrice du Service Social d’Aide aux Émigrants
Authors: Assathiany  , Didier Marie-Thérèse 
Published: November 2023

S.S.A.E. (Service Social aux Emigrants) est la section française du Service Civil International (1). Le
S.S.A.E. est une association privée fondée en 1924, reconnue d’utilité publique en 1932.
Son budget est financé par des subventions (Ministère du Travail et F.A.S.) et les cotisations de ses membres.
Cette association s’est fixé pour objectifs de :
— venir en aide :
• aux réfugiés politiques ;
• aux travailleurs migrants ;
— résoudre les problèmes posés par le travail international.
Ses membres sont des assistants sociaux, spécialement formés pour accueillir un public spécifique. La formation de base comprend 3 stages échelonnés sur un an, à la fois au siège à Paris et sur le lieu d’intervention choisi en province.
Seed treatment using Carbendazim fungicide and weed management by Tamar Adama herbicide studies on commercial crop sugarcane [Hybrid-517] variety
Authors: G Chaya 
Published: November 2023

Studies on commercial sugarcane [HYBRID-517] variety sowing in 11/2 acres from the year 2019 to 2023 plantation of commercial crop data field visit collected from farmer sowing duration September 2019 to September 2023 yield obtained was 83tons, subsequent next yield received range will be 62.085 tons. The present study revealed on about for seed treatment utilized carbendazim fungicide and for weed control management tamar adama, round up, soloro,Atrazine 2kg/L applied on field for sowing the crop duration of 1 to 40days. The efficacy and yield of crops obtained was in good quality nearly 100 tons. Usage of fungicide and herbicide play a vital role in plantation of commercial crop with good yield of 83 tons. Further application scenario of sugarcane undergoes enzymatic hydrolysis to form cellulosic network of elongated fiber shaped nanomaterials had wider application in Biomedical applications, sensor devices , encapsulation of nano coatings.
Semiotika Riffaterre Puisi “Dongeng Marsinah” Karya Sapardi Djoko Damono
Authors: Zhoafir Muhammad , Al Anshory Abdul Muntaqim 
Published: November 2023

The poem "Dongeng Marsinah" is part of an anthology entitled "Melip the Distance" by Sapardi Djoko Damono which was published in 2017. This article will describe an analysis of the poem based on Riffaterre's semiotics. This research uses descriptive qualitative methods. The data collection techniques used were reading and note-taking techniques. Data analysis techniques include data presentation, data reduction, and drawing conclusions. The results of the research show that the heuristic and hermeneutic reading of the poem is a description of the events experienced by Marsinah, the indirectness of the expression which consists of changing meaning, distorting meaning, and creating art, the matrix in the form of Marsinah as a figure who was persecuted and killed just because of her role demanding freedom of opinion, a model in the form of Marsinah and a watch, variants implied in each lyric, and a hypogram in the form of an incident experienced by Marsinah, who was declared missing after leading her fellow workers to protest and strike and her body was found in the forest with signs of severe torture.Keywords: poetry; Riffaterre; semioticsAbstrakPuisi “Dongeng Marsinah” merupakan bagian dari antologi berjudul “Melip the Distance” karya Sapardi Djoko Damono yang terbit tahun 2017. Artikel ini akan menggambarkan telaah puisi itu berdasarkan semiotika Riffaterre. Penelitian ini menggunakan metode kualitatif deskriptif. Teknik pengumpulan data yang digunakan adalah teknik membaca dan mencatat. Teknik analisis data meliputi penyajian data, reduksi data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pembacaan heuristik dan hermeneutik puisi itu sebagai gambaran peristiwa yang dialami Marsinah, ketidaklangsungan ungkapan yang terdiri dari perubahan makna, distorsi makna, dan berkarya seni, matrix dalam wujud Marsinah sebagai sosok yang dianiaya dan dibunuh hanya karena perannya menuntut kebebasan berpendapat, model dalam wujud Marsinah dan jam tangan, varian yang tersirat dalam setiap lirik, dan hipogram berupa kejadian yang dialami Marsinah, dinyatakan hilang setelah menggiring rekan-rekan buruhnya melakukan aksi protes dan mogok kerja dan mayatnya ditemukan di hutan dengan tanda-tanda penyiksaan berat.Kata kunci: puisi; Riffaterre; semiotika
Peningkatan Kemampuan Menulis Teks Laporan Hasil Observasi dengan High Order Thinking
Authors: Sobari Teti , Fauziya Diena San , Satrio Aji , Aryana Suhud 
Published: November 2023

In the 21st century, humanity entered the industrial era 4.0 and will soon enter the social era 5.0. A simple way to prepare yourself to face these challenges is to change your mindset in learning something. This article will describe the ability to write observation report texts through HOTS-based learning for high school students in Class X SMAS PGRI Cianjur Regency with a population of 30 people. Test sheets and observation sheets are tools used in data collection. Based on the results of data collection and processing, information was obtained that students' ability to write observation report texts increased after participating in lessons that used HOTS compared to those that used LOTS. With the results, the average score of 30 students was 79.2, then all of the 30 students got a score above 70, which means 100% of students were said to have exceeded the KKM.Keywodrs: observation results; High Order Thinking; reportAbstrakPada abad 21 umat manusia memasuki era industry 4.0 dan segera memasuki era sosial 5.0. Cara sederhana untuk mempersiapkan diri dalam menghadapi tantangan tersebut adalah dengan mengubah pola pikir dalam belajar sesuatu. Artikel ini akan mendeskripsikan kemampuan menulis teks laporan hasil observasi melalui pembelajaran berbasis HOTS siswa SMA kelas X. Penelitian menggunakan metode eksperimen one shot case study sebagai desain penelitiannya yang dilakukan di kelas. Kelas X SMAS PGRI Kabupaten Cianjur dengan populasi 30 orang. Lembar tes dan lembar observasi merupakan alat yang digunakan dalam pengumpulan data. Berdasarkan hasil pengumpulan dan pengolahan data diperolah informasi bahwa kemampuan siswa dalam menulis teks laporan observasi meningkat setelah mengikuti pembelajaran yang menggunakan HOTS dibanding yang menggunakan LOTS. Dengan hasil nilai rata-rata dari 30 siwa adalah sebesar 79.2 kemudian dari 30 siswa tersebut seluruhnya mendapatkan nilai di atas 70 yang artinya 100% siswa dikatakan sudah melebihi KKM.Kata kunci: hasil observasi; High Order Thinking; laporan
Analisis Pengaruh Profitabilitas, Likuiditas, dan Ukuran Perusahaan Terhadap Nilai Perusahaan Pada Perusahaan Yang Terdaftar di Jakarta Islamic Index (JII) Tahun 2017-2021.
Authors: Fatihul Birri Muhammad , Zakiyah Makhshushi 
Published: November 2023

Fanatisme dan pandemi covid 19 beberapa tahun silam mempengaruhi terhadap minat para investor untuk berinvetasi, sehingga berdampak pada pergerakan saham, transaksi saham dapat menunjukkan nilai perusahaan. Tingkat profitabilitas, likuiditas, dan ukuran perusahaan dianggap dapat mempengaruhi nilai perusahaan. Tetapi hasil penelitian-penelitian yang dilakukan sebelumnya justru menujukkan kesimpulan yang berbeda-beda atau tidak konsisten. Penelitian dilakukan dengan tujuan untuk mengetahui pengaruh variabel profitabilitas yaitu Return on Asset (ROA), likuiditas yaitu rasio lancar atau current ratio (CR), dan ukuran perusahaan (firm size) terhadap nilai perusahaan yaitu price to book value (PBV), secara parsial (bagian) dan simultan (bersamaan).
Penelitian ini menggunakan data sekunder dengan pendekatan kuantitatif melalui uji deskriptif, uji asumsi klasik, dan uji regresi linier berganda. Teknik pengambilan sampel menggunakan metode purposive sampling, dengan 13 perusahaan sebagai sampel penelitian dari total 51 perusahaan yang menjadi populasi. Adapun penelitian ini dilakukan pada perusahaan yang terdaftar di Jakarta Islamic Index (JII) didalam website bursa efek Indonesia www.idx.co.id.
Penelitian ini menghasilkan kesimpulan yang menunjukkan bahwa profitabilitas berpengaruh signifikan terhadap nilai perusahaan, hal ini ditunjukkan dengan t hitung > t tabel (5,824 > 1,99962) dan nilai signifikansi < 0.05 (0,00 < 0,005), likuiditas tidak berpengaruh terhadap nilai perusahaan, dimana t hitung < t tabel (0,615 < 1,99962) dan nilai signifikansi > 0,05 (0,514 > 0,05), ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan, karena nilai t hitung < t tabel (-1.971 < 1,99962) dengan nilai signifikansi > 0,05 (0,059 > 0,05). Secara simultan profitabiltas, likuiditas, dan ukuran perusahaan berpengaruh terhadap nilai perusahaan, hal ini dibuktikan dengan nilai F hitung > F tabel (22,340 > 2,76) dengan nilai signifikansi < 0,05 (0,000 < 0,05).
Differences In Knee Valgus Degrees In Cutting And Drop Landing On The Dominant And Non-Leg Dominant In High School Basketball Players
Authors: Bila Dhea Salsa , Irawan Dimas Sondang , Rahim Anita Faradilla 
Published: November 2023

Background: Basic techniques, physical endurance, and teamwork in basketball are components needed to improve individual quality to be able to play with good performance. Basic techniques and movements often occur quickly and suddenly, including cutting and drop landing. Both of these movements are prone to knee injury. The majority of lower extremity injuries in basketball players are anterior cruciate ligament (ACL) strains. Observation of the knee valgus angle is required to assess the risk of knee injury. One of the risks has the potential to cause a knee injury is the dominant and non-dominant knee. This is because the leg have an important role in controlling posture and stability. Purpose: this study was to determine the differences in the risk factors for the dominant and non-dominant leg in cutting and drop landing. Methods: The research was analytic observational, a cross-sectional study design. The population in this study were high school basketball players in Malang City with a total sample of 22 people the inclusion and exclusion criteria (n=22). Data collection was carried outthe Waterloo Footedness Questionnaire-Revised (WFQ-R) and Frontal Plane Projection Angle (FPPA) as measuring tools using the kinovea software. Results: Based on the analysis Wilcoxon test forcutting and drop landing movements, a value of 0.036 (p <0.05) was obtained for the non-dominant leg, which means that there is a significant difference between the two movements. Conclusion: It canbe concluded that there are differences movements of cutting and drop landing on the non-dominant leg compared to the dominant leg.