bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-tumour Activity of Bioactive Compounds Isolated from the Hemolymph and Mucus of the Garden Snail Helix aspersa against a Panel of Human Cancer Cell Lines
Authors: Petrova Maria , Vlahova Zlatina , Schröder Maria , Tzintzarov Alexander , Velkova Lyudmila , Kaynarov Dimitar , Dolashki Aleksandar , Dolashka Pavlina , Ugrinova Iva 
Published: October 2023

Cancer remains a significant global health concern, necessitating the search for new effective and safe anti-cancer agents. Natural products derived from plants and animals, including mollusks like snails, have gained attention as potential sources of novel anti-cancer compounds. Haemocyanins (Hcs), large copper-containing glycoproteins involved in oxygen transport in mollusks, have shown promise as anti-cancer agents. This study focuses on evaluating the in vitro anti-tumour efficacy of bioactive substances obtained from the hemolymph of the garden snail Helix aspersa on various human cancer cell lines representing different types of cancer. The results demonstrate that certain hemocyanin subunits from H. aspersa exhibit cytotoxic activity comparable to cisplatin, a widely used chemotherapy drug. Additional assays confirm the cytotoxic effects of the tested substances on cancer cells. The study underscores the potential of natural compounds from H. aspersa as alternative therapeutic agents for cancer treatment, while highlighting the need for further investigation. The identification of specific proteins responsible for the observed anti-proliferative effects in the mucus of H. aspersa provides insights for the development of novel cancer therapies.
Neurological Soft Signs and Social Cognition in Patients with Schizophrenia: the Missing Link
Authors: Guevara Kaloyan , Kostadinov Kostadin 
Published: October 2023

Schizophrenia is a debilitating mental disorder characterised by a pronounced decline in mental, physical, and social functioning. Our study aims to investigate the relationship between the socio-cognitive and the subtle motor and sensory symptoms of schizophrenia, which are, respectively, represented by facial emotion recognition deficits (FERD) and neurological soft signs (NSS). Thus, we assessed 60 patients diagnosed with schizophrenia. FERD was measured with the “Averaged Karolinska Directed Emotional Faces” set, and NSS was assessed with the Neurological Evaluation Scale. A strong and significant negative correlation was found between the NSS total score and the FERD total score (r = –0.7, p < 0.001). There was also a significant negative correlation between several of the subscores of both instruments. The results show that impaired social cognition is significantly associated with soft neurological disturbances in patients suffering from schizophrenia. Taken together, this reinforces the notion that schizophrenia is characterised by dysfunction and disconnection of a complex cerebral network, which can probably be influenced by psychosocial and physical nonpharmacological therapeutic interventions.
Dosimetric Analysis of Limiting Pelvic Bone Dose in Intensity-modulated Radiotherapy for Cervical Cancer
Authors: Qiu Hao , Liu Xin , Fang Meifang , Wu Xianxiang , Zhou Dawei , Cai Hanfei 
Published: October 2023

Numerous studies have indicated the significant importance of pelvic dose in the radiotherapy process for cervical cancer patients. However, research on the actual pelvic bone dose in the treatment of cervical cancer patients using different techniques is currently relatively limited. In this study, we selected 50 postoperative cervical cancer patients. For each patient, three treatment plans with pelvic dose constraints were designed: sIMRT, VMAT, and HT. Statistical analysis was conducted on the target area and organ at risk parameters of the three groups of plans. The results indicate that all three treatment plans meet the clinical requirements. Regarding organs at risk, compared to the sIMRT and VMAT groups, the HT group showed a reduction of 11.85% and 11.07%, respectively, in V40 of bladder. Additionally, compared to the sIMRT and HT groups, the VMAT group exhibited a reduction of 14.94% and 9.53%, respectively, in V10 of pelvic bone. Furthermore, compared to the sIMRT and HT groups, the VMAT group showed a reduction of 10.76% and 6.75%, respectively, in V20 of pelvic bone, and these differences were also statistically significant (t = 21.630, t = –16.621, P < 0.05). In summary, individualized treatment design can be conducted in clinical practice based on the specific conditions of patients.
Broadband Modulation, Self‐Driven, and Self‐Cleaning Smart Photovoltaic Windows for High Efficiency Energy Saving Buildings
Authors: Na Zongxu , Liang Xiao , Wang Hao , Yu Li , Fan Chunming , Wang Qian , Wang Xianbao , Yang Huai 
Published: October 2023

AbstractSmart photovoltaic windows (SPWs) are an emerging green technology presenting energy‐saving by combining solar irradiance regulation and solar energy harvesting. The SPWs integrating extraordinary energy‐saving performance, stable and controllable operational mode, and diverse functionality are essential for devising high efficiency energy‐saving buildings (ESBs). However, the attainment of such features has yet to be realized in current iterations of SPWs. Herein, a conceptual demonstration of a split‐type broadband modulation, self‐driven, and self‐cleaning SPWs is presented by coupling a silicon solar cell with a multifunctional chromogenic unit (MCU) for creating highly efficient ESBs. Within the multilayer structured MCU, thermal‐responsive polymer stabilized liquid crystal (PSLC) and VO2@SiO2 nanoparticles act as chromic component, enabling broadband light modulation. Thanks to the excellent electrothermal effect of indium tin oxide (ITO), the phase transition of PSLC and VO2@SiO2 nanoparticles can be induced by the electrical power output generated by the silicon solar cell. Therefore, the transparency of SPWs can be manipulated according to the occupant's preference during the daytime. Moreover, a superhydrophobic SiO2 coating provides SPWs with self‐cleaning capability which effectively reduces water resource consumption and eliminates the inconvenience of window cleaning, while providing occupants with a clear view even in complex weather conditions.
Engineering In Situ Catalytic Cleaning Membrane Via Prebiotic‐Chemistry‐Inspired Mineralization
Authors: Yang Xiaobin , Wen Yajie , Li Yangxue , Yan Linlin , Tang Chuyang Y. , Ma Jun , Darling Seth B. , Shao Lu 
Published: October 2023

AbstractPressure‐driven membrane separation promises a sustainable energy‐water nexus but is hindered by ubiquitous fouling. Natural systems evolved from prebiotic chemistry offer a glimpse of creative solutions. Herein, a prebiotic‐chemistry‐inspired aminomalononitrile (AMN)/Mn2+‐mediated mineralization method is reported for universally engineering a superhydrophilic hierarchical MnO2 nanocoating to endow hydrophobic polymeric membranes with exceptional catalytic cleaning ability. Green hydrogen peroxide catalytically triggered in‐situ cleaning of the mineralized membrane and enabled operando flux recovery to reach 99.8%. The mineralized membrane exhibited a 9‐fold higher recovery compared to the unmineralized membrane, which is attributed to active catalytic antifouling coupled with passive hydration antifouling. Electron density differences derived from the precursor interaction during mediated mineralization unveiled an electron‐rich bell‐like structure with an inner electron‐deficient Mn core. This work paves the way to construct multifunctional engineered materials for energy‐efficient water treatment as well as for diverse promising applications in catalysis, solar steam generation, biomedicine, and beyond.
Iontronic Textile‐based Capacitive Pressure Sensor for Unconstrained Respiration and Heartbeat Monitoring
Authors: Feng Zhiping , He Qiang , Qiu Jing , Wang Xue , Lin Yinggang , Wu Yufen , Yang Jin 
Published: October 2023

AbstractLong‐term surveillance records of cardiac activity are essential for people at potential risk of cardiovascular disease. However, the existing mainstream technologies for cardiac monitoring, such as electrocardiography (ECG) and photoplethysmography (PPG), are inconvenient and prone to skin allergies due to contact measurements. Ballistocardiography (BCG) is a vibration signal related to cardiac activity, which can be monitored in an unconstrained way. Herein, an iontronic textile‐type flexible capacitive pressure sensor (i‐TFCPS) based on ionic liquid doped hollow‐porous fiber is developed to monitor physiological signals. With a high sensitivity of 7.26 kPa−1, a wide pressure range (10 Pa–600 kPa), a fast response time of 30 ms, and decent durability over 3500 cycles, the i‐TFCPS is simultaneously capable of detecting and tracking the static and dynamic changes of sitting posture, and subtle physiological information, such as respiration and BCG signals. Benefits from the iontronic textile as sensitive dielectric, the capacitive pressure sensor is able to monitor the subtle BCG signal under high static pressure in an unconstrained state, showing great potential for unobtrusive cardiac monitoring in home, office and hospital.
Anti‐Freezing Wearable Tactile Sensors Prepared by Laser Processing of Crumpled Xanthan Gum‐Based Hydrogels
Authors: Zhang Wan , Huang Yuan , Zhou Hang , Nie Zanxiang , Jin Shunyu 
Published: October 2023

AbstractWearable piezoresistive tactile sensors are becoming increasingly popular in fields related to human motion/health monitoring, and artificial intelligence. However, piezoresistive materials are still limited in terms of safety and biocompatibility in medical settings, as well as availability under harsh conditions. Herein, elastic and biocompatible hydrogels are prepared by cross‐linking of xanthan gum, polyvinyl alcohol, carbon nanotubes, and glycerol. The presence of glycerol results in hydrogel exhibiting an outstanding freezing resistance (−40 °C). Meanwhile, the controllable, large‐scale, and facile two‐step direct laser writing process allows the fabrication of hydrogels with double‐rough surface structures. By tuning surface roughness, the sensors with the resulting hydrogels show a wide detection range with high sensitivities of 27.5, 5.4, and 2.1 kPa−1 under pressures of 0.1–6, 6–25, and 25–80 kPa. The sensors also display fast response time (≈126 ms), low detection limit (2.26 Pa), good reproducibility of sensing performance (1000 cycles), relevant freezing tolerance (−40 °C), and decent environmental stability (over 30 days). This work provides a low‐cost, ease of manipulation, high reproducible, and large‐scale way for the microstructure engineering of natural‐polymer hydrogels and promotes their widespread applications.
Visible‐Light‐Induced Multicomponent Reaction of Aromatic Aldehydes, Amines and Sodium Difluoromethanesulfinate: Synthesis of CF2H‐Substituted Secondary Amines
Authors: Zhang Shanshan , Geng Yang , Jiao Jialong , Zou Dapeng , Wu Yangjie , Wu Yusheng 
Published: October 2023

AbstractA visible‐light induced multicomponent reaction of aromatic aldehydes, amines and sodium difluoromethanesulfinate for the synthesis of fluorinated secondary amines has been investigated. The protocol affords a convenient pathway for the introduction of difluoromethyl group into imines, which generated in situ by the reaction of aldehydes and amines. A diverse range of fluorinated secondary amines were synthesized in 43%–79% yields under room temperature. In addition, a plausible mechanism was proposed based on several control experiments.
Trimetallic Oxide Electrocatalyst for Enhanced Redox Activity in Zinc–Air Batteries Evaluated by In Situ Analysis
Authors: Kumar Ramasamy Santhosh , Mannu Pandian , Prabhakaran Sampath , Nga Ta Thi Thuy , Kim Yangsoo , Kim Do Hwan , Chen Jeng‐Lung , Dong Chung‐Li , Yoo Dong Jin 
Published: October 2023

AbstractResearchers are investigating innovative composite materials for renewable energy and energy storage systems. The major goals of this studies are i) to develop a low‐cost and stable trimetallic oxide catalyst and ii) to change the electrical environment of the active sites through site‐selective Mo substitution. The effect of Mo on NiCoMoO4 is elucidated using both in situ X‐ray absorption spectroscopy and X‐ray diffraction analysis. Also, density functional theory strategies show that NiCoMoO4 has extraordinary catalytic redox activity because of the high adsorption energy of the Mo atom on the active crystal plane. Further, it is demonstrated that hierarchical nanoflower structures of NiCoMoO4 on reduced graphene oxide can be employed as a powerful bifunctional electrocatalyst for oxygen reduction/evolution reactions in alkaline solutions, providing a small overpotential difference of 0.75 V. Also, Zn–air batteries based on the developed bifunctional electrocatalyst exhibit outstanding cycling stability and a high‐power density of 125.1 mW cm−2. This work encourages the use of Zn–air batteries in practical applications and provides an interesting concept for designing a bifunctional electrocatalyst.
Suppressed Water Reactivity by Zincophilic‐Hydrophobic Electrolyte Additive for Superior Aqueous Zn Metal Batteries
Authors: Wang Yahui , Zhao Ran , Liu Mingquan , Yang Jingjing , Zhang Anqi , Yue Jiasheng , Wu Chuan , Bai Ying 
Published: October 2023

AbstractAs one of the most promising anodes of aqueous batteries, Zn metal faces uncontrollable side reactions and deleterious dendrite growth, which drastically compromise its cycle life and Coulombic efficiency (CE). To tackle these issues, a versatile electrolyte additive is reported that can regulate the solvation structure, adsorb on the Zn surface, and in situ generate a novel zincophilic‐microhydrophobic interphase to isolate the anode from the reactive water molecules. Benefiting from its triple effects on the water reactivity modulation, the Zn metal anode exhibits excellent reversibility with an ultra‐high average CE value of 99.92% at 5 mA cm−2 in the ZnSO4 electrolyte system, and the Zn||Zn symmetric cell with ethanesulfonamide additive achieves a long lifespan over 6000 h. The merits of ESA additives are further displayed in the Zn//MnO2 full cells and Zn ion hybrid capacitors, exhibiting excellent capacity retention of 81.60% at 5 C over 1000 cycles, and a 92.25% capacity retention over 50 000 cycles at 5 A g−1, respectively. What's more, the full cells exhibit outstanding stability of 100% capacity retention after 120 cycles at 0.1 C. This strategy shows a promising alternative for the further development of aqueous Zn metal batteries with low‐cost ZnSO4‐based electrolytes.
Spatial proteomics of hippocampal subfield‐specific pathology in Alzheimer's disease and primary age‐related tauopathy
Authors: Walker Jamie M. , Orr Miranda E. , Orr Timothy C. , Thorn Emma L. , Christie Thomas D. , Yokoda Raquel T. , Vij Meenakshi , Ehrenberg Alexander J. , Marx Gabriel A. , McKenzie Andrew T. , Kauffman Justin , Selmanovic Enna , Wisniewski Thomas , Drummond Eleanor , White Charles L. , Crary John F. , Farrell Kurt , Kautz Tiffany F. , Daoud Elena V. , Richardson Timothy E. 
Published: October 2023

AbstractINTRODUCTIONAlzheimer's disease (AD) and primary age‐related tauopathy (PART) both harbor 3R/4R hyperphosphorylated‐tau (p‐tau)‐positive neurofibrillary tangles (NFTs) but differ in the spatial p‐tau development in the hippocampus.METHODSUsing Nanostring GeoMx Digital Spatial Profiling, we compared protein expression within hippocampal subregions in NFT‐bearing and non‐NFT‐bearing neurons in AD (n = 7) and PART (n = 7) subjects.RESULTSProteomic measures of synaptic health were inversely correlated with the subregional p‐tau burden in AD and PART, and there were numerous differences in proteins involved in proteostasis, amyloid beta (Aβ) processing, inflammation, microglia, oxidative stress, and neuronal/synaptic health between AD and PART and between definite PART and possible PART.DISCUSSIONThese results suggest subfield‐specific proteome differences that may explain some of the differences in Aβ and p‐tau distribution and apparent pathogenicity. In addition, hippocampal neurons in possible PART may have more in common with AD than with definite PART, highlighting the importance of Aβ in the pathologic process.Highlights
Synaptic health is inversely correlated with local p‐tau burden.
The proteome of NFT‐ and non‐NFT‐bearing neurons is influenced by the presence of Aβ in the hippocampus.
Neurons in possible PART cases share more proteomic similarities with neurons in ADNC than they do with neurons in definite PART cases.
Photocatalytic Dehalogenative Deuteration of Halides over a Robust Metal–Organic Framework
Authors: Luo Tian , Wang Zi , Chen Yinlin , Li Hengzhao , Peng Mengqi , Tuna Floriana , McInnes Eric J. L. , Day Sarah J. , An Jie , Schröder Martin , Yang Sihai 
Published: October 2023

AbstractDeuterium labelling of organic compounds is an important process in chemistry. We report the first example of photocatalytic dehalogenative deuteration of both arylhalides and alkylhalides (40 substrates) over a metal–organic framework, MFM‐300(Cr), using CD3CN as the deuterium source at room temperature. MFM‐300(Cr) catalyses high deuterium incorporation and shows excellent tolerance to various functional groups. Synchrotron X‐ray powder diffraction reveals the activation of halogenated substrates via confined binding within MFM‐300(Cr). In situ electron paramagnetic resonance spectroscopy confirms the formation of carbon‐based radicals as intermediates and reveals the reaction pathway. This protocol removes the use of precious‐metal catalysts from state‐of‐the‐art processes based upon direct hydrogen isotope exchange and shows high photocatalytic stability, thus enabling multiple catalytic cycles.
Towards Artificial Visual Sensory System: Organic Optoelectronic Synaptic Materials and Devices
Authors: Chen Hao , Cai Yunhao , Han Yinghui , Huang Hui 
Published: October 2023

AbstractDeveloping an artificial visual sensory system requires optoelectronic materials and devices that can mimic the behavior of biological synapses. Organic/polymeric semiconductors have emerged as promising candidates for optoelectronic synapses due to their tunable optoelectronic properties, mechanic flexibility, and biological compatibility. In this review, we discuss the recent progress in organic optoelectronic synaptic materials and devices, including their design principles, working mechanisms, and applications. We also highlight the challenges and opportunities in this field and provide insights into potential applications of these materials and devices in next‐generation artificial visual systems. By leveraging the advances in organic optoelectronic materials and devices, we can envision its future development in artificial intelligence.
Challenging collaborative archaeology: Remote sensing of African American burials in a majority‐White, rural town
Authors: González‐Tennant Edward , González‐Tennant Diana 
Published: October 2023

AbstractInterest in documenting and preserving African American burial grounds is rapidly expanding across the United States of America. This work has wide support and numerous groups advocate for the creation of such projects. In majority‐White, rural communities, these projects can elicit strong reactions — positive and negative. This article discusses the challenges arising in such locations by reviewing a recent cemetery mapping and ground‐penetrating radar (GPR) survey of the Cedar Key Cemetery located on the Gulf Coast of Florida. Numerous challenges, including concentrated attempts to halt the work, emerge over the duration of the project. In Cedar Key, years of transparent engagement between community members and archaeologists results in the emergence of a diverse stakeholder community supporting the project and guaranteeing its completion. Today, this group is mobilizing to document and commemorate similar places in nearby communities.
Utilizing Nanostructured Materials for Hydrogen Generation, Storage, and Diverse Applications
Authors: Saeed Mohsin , Marwani Hadi M. , Shahzad Umer , Asiri Abdullah M. , Hussain Ijaz , Rahman Mohammed M. 
Published: October 2023

AbstractThe rapid advancement of refined nanostructures and nanotechnologies offers significant potential to boost research activities in hydrogen storage. Recent innovations in hydrogen storage have centered on nanostructured materials, highlighting their effectiveness in molecular hydrogen storage, chemical storage, and as nanoconfined hydride supports. Emphasizing the importance of exploring ultra‐high‐surface‐area nanoporous materials and metals, we advocate for their mechanical stability, rigidity, and high hydride loading capacities to enhance hydrogen storage efficiency. Despite the evident benefits of nanostructured materials in hydrogen storage, we also address the existing challenges and future research directions in this domain. Recent progress in creating intricate nanostructures has had a notable positive impact on the field of hydrogen storage, particularly in the realm of storing molecular hydrogen, where these nanostructured materials are primarily utilized.
Insights into Circular Economy Potential of Lithium by System Dynamic Modelling of Material Streams
Authors: Lähdesmäki Seppo , Hanski Jyri , Huttunen‐Saarivirta Elina 
Published: October 2023

AbstractLithium is a key raw material for producing lithium‐ion batteries. This study applies system dynamics modelling to demonstrate the (1) global lithium demand in specific lithium applications from 2005 to 2050, (2) the adequacy of lithium reserves for future lithium demand, (3) lithium content of waste streams throughout lithium value chain and (4) potential of various circular strategies for answering to the rising lithium demand. According to the modelling results, the main lithium application is battery electric vehicle batteries (almost 60 % in 2023 to 80–90 % by 2050) with current battery chemistries. Without circular strategies, 75–85 % of lithium is wasted throughout the value chain. Circular strategies may reduce the waste considerably (7–47 %), but to maintain sustainable supply of lithium a stacking of multiple complementary circular strategies over the lithium value chain is required.
Cultivating sustainable consumption: The role of harmonious cultural values and pro‐environmental self‐identity
Authors: Zhao Anita Lifen , Dermody Janine , Koenig‐Lewis Nicole , Hanmer‐Lloyd Stuart 
Published: October 2023

AbstractThis paper investigates the connections between harmonious cultural values, pro‐environmental self‐identity and consumers' sustainable consumption behaviours spanning acquisition, usage and disposal. It evaluates the relevance of Chinese cultural values that purport harmony between humans, nature and society that is, man‐nature orientation, and horizontal/vertical dimensions of individualism collectivism. The results from the online survey with 503 urbanised Chinese reveals these values disparately influence this consumption. Despite the limited direct behavioural effect of these harmonious values, pro‐environmental self‐identity plays an important role in mediating their indirect effects on the five behaviours. This paper therefore extends theorisation of the values‐identity‐behaviour relationship from a cultural‐values orientation perspective. It offers new insights to understand urbanised Chinese consumers sustainable consumption behaviours.