bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing the response of CO2 emissions to business cycle in a developing economy: evidence for South Africa post-apartheid era
Authors: Espoir Delphin Kamanda , Sunge Regret , Mduduzi Biyase , Bannor Frank , Matsvai Simion 
Published: January 2024

Introduction: This research addresses the response of CO2 emissions to economic fluctuations in South Africa post-Apartheid, covering the period 1990–2018. While previous studies focused on developed countries, limited attention has been given to sub-Saharan developing nations. The study challenges the assumption of constant emissions elasticity in current forecasts.Methods: The study employs a two-step strategy. Firstly, the rolling window regression with Hodrick-Prescott filtering was used to investigate whether the CO2 emissions elasticity varies over time. Secondly, a Markov-switching approach was used to examine the regime-switching behavior in GDP.Results and Discussion: Results suggest that CO2 emisssions elasticity varies over time. This was confirmed through alternative filtering techniques (Christiano-Fitzgerald, Baxter King, and the Butterworth filter). Markov-switching analysis revealed a regime-switching behavior in GDP, indicating negative CO2 emissions elasticity during recessions and positive elasticity during expansions. These findings persist even when accounting for monetary policy shocks and productivity shocks in the Environmental Dynamic Stochastic General Equilibrium (E-DSGE) model. Noteworthy is that South Africa is among the top 20 greenhouse gas emitters globally.Conclusion and recommendations: The study recommends tailored carbon-pricing policies that are conscious to the countercyclical nature of business cycles. Pricing emissions higher during economic upswings aligns with periods of growth. Additionally, the government is advised to invest in research and development for energy conservation, efficiency, and renewable technologies to counterbalance emissions growth. Implementing emission caps and tax incentives can further enforce pollution abatement measures. Policymakers should consider these asymmetrical responses when addressing global warming challenges in South Africa.
Construction and optimization of ecological security patterns in the songnen plain
Authors: Liu Jiping , Chen Baolong , Zhang Meng , Wan Daiji , Liu Xuan 
Published: January 2024

To address the ecological security issues in the Songnen Plain, this study constructs the ecological security pattern by using the Multi-Criteria Evaluation Method, Minimum Cumulative Resistance (MCR) model, and Circuit Connectivity Model. Results show that: 1) The ecological source areas were 66, 52, and 56 blocks in 2000, 2010, and 2020 respectively, which are composed mainly of forests, water bodies, and wetlands. The distribution of resistance values of the ecological resistance surface shows a gradually increases trend from the source areas to the outward surrounding regions. The high and low value areas are more dispersed, consisting with the overall spatial distribution; 2) The numbers of ecological corridors show a temporal declining trend from 178 in 2000 to 159 in 2020 with a reduction of 645.46 km in total length. Node areas are mainly distributed in the southwestern and central-eastern regions and its number decreased from 232 in 2000 to 229 in 2020. The sizes of obstacle areas are 74029.52 km2, 70203.72 km2, and 75529.72 km2 in the three periods; 3) The size of important ecological source areas has decreased by 5779.16 km2, the area of medium ecological source areas has increased by 11466.44 km2, and the area of general ecological source areas has increased by 9509.16 km2. The areas being classified as ecological conservation, ecological enhancement, ecological restoration, and ecological control are 30346.68 km2, 8480.56 km2, 51473.92 km2, and 122047.48 km2, respectively. The multiple spatial pattern optimization strategies are proposed based on the identified ecological source areas, corridors, node points, and other comprehensive ecological security patterns. It not only provides practical reference for the ecological restoration and ecological protection in the Songnen Plain, but also can be used for the ecological security pattern investigations in other study regions in the world.
Unveiling the genetic basis of Fusarium wilt resistance in chickpea using GWAS analysis and characterization of candidate genes
Authors: Alsamman Alsamman M. , H. Mousa Khaled , Istanbuli Tawffiq , Abd El-Maksoud Mamdouh M. , Tawkaz Sawsan , Hamwieh Aladdin 
Published: January 2024

Introduction: Chickpea is a legume crop that thrives in regions with semi-arid or temperate climates. Its seeds are an excellent source of proteins, carbohydrates, and minerals, especially high-quality proteins. Chickpea cultivation faces several challenges including Fusarium wilt (FW), a major fungal disease that significantly reduces productivity.Methods: In this study, a Genome-wide Association Analysis (GWAS) was conducted to identify multiple genomic loci associated with FW resistance in chickpea. We conducted a comprehensive evaluation of 180 chickpea genotypes for FW resistance across three distinct locations (Ethiopia, Tunisia, and Lebanon) during the 2-year span from 2015 to 2016. Disease infection measurements were recorded, and the wilt incidence of each genotype was calculated. We employed a set of 11,979 single nucleotide polymorphisms (SNPs) markers distributed across the entire chickpea genome for SNP genotyping. Population structure analysis was conducted to determine the genetic structure of the genotypes.Results and Discussion: The population structure unveiled that the analyzed chickpea germplasm could be categorized into four sub-populations. Notably, these sub-populations displayed diverse geographic origins. The GWAS identified 11 SNPs associated with FW resistance, dispersed across the genome. Certain SNPs were consistent across trials, while others were specific to particular environments. Chromosome CA2 harbored five SNP markers, CA5 featured two, and CA4, CA6, CA7, and CA8 each had one representative marker. Four SNPs demonstrated an association with FW resistance, consistently observed across a minimum of three distinct environments. These SNPs included SNP5826041, SNP5825086, SNP11063413, SNP5825195, which located in CaFeSOD, CaS13like, CaNTAQ1, and CaAARS genes, respectively. Further investigations were conducted to gain insights into the functions of these genes and their role in FW resistance. This progress holds promise for reducing the negative impact of the disease on chickpea production.
Development and verification of a combined immune- and cancer-associated fibroblast related prognostic signature for colon adenocarcinoma
Authors: Wei Jingsun , Ge Xiaoxu , Qian Yucheng , Jiang Kai , Chen Xin , Lu Wei , Yang Hang , Fu Dongliang , Fang Yimin , Zhou Xinyi , Xiao Qian , Tang Yang , Ding Kefeng 
Published: January 2024

IntroductionTo better understand the role of immune escape and cancer-associated fibroblasts (CAFs) in colon adenocarcinoma (COAD), an integrative analysis of the tumor microenvironment was performed using a set of 12 immune- and CAF-related genes (ICRGs).MethodsUnivariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses were used to establish a prognostic signature based on the expression of these 12 genes (S1PR5, AEN, IL20RB, FGF9, OSBPL1A, HSF4, PCAT6, FABP4, KIF15, ZNF792, CD1B and GLP2R). This signature was validated in both internal and external cohorts and was found to have a higher C-index than previous COAD signatures, confirming its robustness and reliability. To make use of this signature in clinical settings, a nomogram incorporating ICRG signatures and key clinical parameters, such as age and T stage, was developed. Finally, the role of S1PR5 in the immune response of COAD was validated through in vitro cytotoxicity experiments.ResultsThe developed nomogram exhibited slightly improved predictive accuracy compared to the ICRG signature alone, as indicated by the areas under the receiver operating characteristic curves (AUC, nomogram:0.838; ICRGs:0.807). The study also evaluated the relationships between risk scores (RS) based on the expression of the ICRGs and other key immunotherapy variables, including immune checkpoint expression, immunophenoscore (IPS), and microsatellite instability (MSI). Integration of these variables led to more precise prediction of treatment efficacy, enabling personalized immunotherapy for COAD patients. Knocking down S1PR5 can enhance the efficacy of PD-1 monoclonal antibody, promoting the cytotoxicity of T cells against HCT116 cells ((p&lt;0.05).DiscussionThese findings indicate that the ICRG signature may be a valuable tool for predicting prognostic risk, evaluating the efficacy of immunotherapy, and tailoring personalized treatment options for patients with COAD.
Epidemiological changes and molecular characteristics of Brucella strains in Ningxia, China
Authors: Liu Guangtian , Ma Xueping , Zhang Ruiqing , Lü Jufen , Zhou Pan , Liu Bofei , Liu Tao , Ren Hui , Liu Zhiguo , Li Zhenjun , Jiang Xuefeng 
Published: January 2024

ObjectiveHuman brucellosis causes serious public health concerns in Ningxia, China.MethodsThis study employed epidemiological, bacteriological, and multiple-locus variable-number tandem repeat analysis (MLVA) methods to conduct an epidemiological investigation, which is necessary for devising tailored control strategies.ResultsBetween 1958 and 2022, 29,892 cases were reported, with an average annual number of cases and incidence of 467 and 7.1/100,000, respectively. The epidemic situation gradually worsened, with cases escalating from 26 cases in 2005 to 6,292 in 2022, with the incidence rate rising from 0.441 in 2005 to 86.83 in 2022. Geographically, the disease spread from a single affected county in 2004 to encompass all 22 counties in 2022. Yanchi County had the highest incidence, followed by the Hongsibao and Tongxin counties. These data suggest that Brucella infection has become a rampant regional concern in human brucellosis. Between 1958 and 2019, a total of 230 Brucella strains were identified across four studied hosts. These strains comprised four species with 12 biovars, including B. melitensis bv. 1, bv. 2, bv. 3, B. abortus bv. 1, bv. 3, bv. 4, bv. 5, bv. 6, bv. 7, B. suis bv. 1 and bv. 3, and B. canis. These data highlight the high species/biovars and host diversity of the Brucella population, posing a substantial challenge to brucellosis surveillance. There was an apparent transition from multiple species/biovars historically to the current dominance of a single species, B. melitensis, emphasizing the requirement for strengthening surveillance of B. melitensis. Genotypes 42 and 116, constituting 96.2% of the total number of genotypes, predominated in panel 1 and MLVA-11, indicating that all strains belong to the East Mediterranean lineage. MLVA cluster analysis revealed persistent transmission of dominant circulating genotypes, presenting an epidemic pattern characterized primarily by epidemiologically related cases with a few sporadic cases. Strains in this study exhibited high genetic homogeneity with strains from the Northwest, and those from Kazakhstan and Mongolia.ConclusionThe epidemic situation of human brucellosis has gradually worsened; the rampant epidemic of the disease has become a regional concern. The present study highlights that implementing the of targeted surveillance and intervention strategies is urge.
Ethnobotanical study of medicinal plants used by the people of Mosop, Nandi County in Kenya
Authors: Maiyo Z. C. , Njeru S. N. , Toroitich F. J. , Indieka S. A. , Obonyo M. A. 
Published: January 2024

Background:Throughout the history, nature has provided mankind with most of their basic needs, which include food, shelter, medicine, clothes, flavours, scents as well as raw materials. Given that they are an integral part of cultural heritage, medicinal plants have played a significant role in human healthcare systems around the world. Investigating various biological resources for use as medicines requires ethnomedicinal studies.Methods:Data on utilization of ethnomedicinal plants from local healers in Kenya’s Mosop Sub-County in Nandi County was documented through open-ended, semi-structured questionnaires. A number of quantitative indices, such as the Use Citation (UC), Informant Consensus Factor (ICF), Use Value (UV), Frequency of Citation (FoC) and Relative Frequency of Citation (RFC) were used to convey the potential medical benefits, vitality and variety of the ethnomedicine.Results:102 informants provided information on 253 ethnomedicinal plant species, classified into 74 families. There were 249 native plant species identified, along with few exotic species:Senegalia senegal(L.) Britton,Persea americanaMill,Carica papayaL. andSolanum betaceumCav. Of all recorded species, 32% and 27% were herbs and trees, respectively. Among plant parts, leaves were most frequently utilized (27%) and roots (26%), while decoctions (21%) were the most widely used formulations. The dominant family was Asteraceae, with 28 species, followed by Lamiaceae, with 19 species. The highest ICF value was 0.778 for a number of parasitic and infectious illnesses, including ringworms, athlete’s foot rot, tetanus, typhoid, intestinal parasites, abscesses, malaria, and amoebiasis. The study’s data validates the region’s widespread use of traditional medicinal plant remedies.Conclusion:The current study will lay a foundation of knowledge for future research investigations. The abundance of knowledge regarding ethnomedicinal species and their medicinal applications will stimulate further phytochemical and pharmacological research, which could lead to the discovery of potentially significant pharmaceuticals.
Family resilience of families with parental cancer and minor children: a qualitative analysis
Authors: Heuser Christian , Schneider Juliane Nora , Heier Lina , Ernstmann Nicole , Nakata Hannah , Petermann-Meyer Andrea , Bremen Rebecca , Karger André , Icks Andrea , Brümmendorf Tim H. , Geiser Franziska 
Published: January 2024

IntroductionEstimated 50,000 minor children in Germany experience a newly diagnosed cancer in one of their parents every year. Family resilience has proven to be an important concept against life crises. However, little research exists regarding family resilience in the context of parental cancer with minor children. Based on the “Family Resilience Framework,” the aim of the study is to investigate the processes of family resilience of affected families. In addition, we explore which combinations of promoting family resilience processes can be characterized.MethodsAs part of the mixed-method quasi-experimental interventional study “F-SCOUT,” a qualitative content analysis was used to analyze the documentation of the “Family-Scouts” (a fixed contact person who advises, accompanies, and supports the families). Documentation was performed by families’ study inclusion (T0), after 3 months (T1) and 9 months (T2) concerning current family situation, organization of everyday life, emotional coping, open communication within the family, and planned tasks.ResultsThe N = 73 families had between one and six children. In 58 (79%) families, the mother had cancer. In the course of the analysis, a category system with 10 main categories and 36 subcategories emerged. Family resilience processes were described to different extents. Combinations of categories promoting family resilience were characterized by the use of social resources, flexibility, economic resources, and open communication.DiscussionThe findings are consistent with existing assumptions about family resilience in terms of the importance of social resources, family cohesion, mutual support, flexibility, open communication, and psychological well-being. In contrast to the findings of previous research, spirituality, and collaborative problem-solving indicate less centrality here. In turn, the findings on economic resources and information-seeking provide a valuable addition to the family resilience literature in the context of parental cancer with minor children.Clinical trial registrationClinicalTrials.gov, identifier NCT04186923.
Theta/beta ratio in EEG correlated with attentional capacity assessed by Conners Continuous Performance Test in children with ADHD
Authors: Wang Tzong-Shi , Wang Syu-Siang , Wang Chang-Li , Wong Shi-Bing 
Published: January 2024

IntroductionAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children worldwide; however, diagnosing ADHD remains a complex task. Theta/beta ratio (TBR) derived from electroencephalography (EEG) recordings has been proposed as a potential biomarker for ADHD, but its effectiveness in children with ADHD remains controversial. Behavioral assessments, such as the Conners Continuous Performance Test–3rd edition (CPT-3), have been utilized to assess attentional capacity in individuals with ADHD. This study aims to investigate the correlation between TBR and CPT-3 scores in children and adolescents with ADHD.MethodsIn a retrospective analysis, we examined patients regularly monitored for ADHD at Taipei Tzu Chi Hospital, who underwent both EEG and CPT-3 assessments. Severity of ADHD was evaluated using parent- and teacher-completed Swanson, Nolan, and Pelham (SNAP)-IV rating scales.ResultsThe study encompassed 55 ADHD patients (41 with abnormal CPT-3 scores, 14 with normal CPT-3 scores) and 45 control subjects. TBR demonstrated elevation in ADHD patients with abnormal CPT-3 scores, indicating its potential to represent attentional capacity akin to behavioral assessments like CPT-3. However, significant correlations between TBR values and CPT-3 variables or SNAP-IV rating scales were not observed. Moreover, TBR values exhibited considerable overlap across the groups, leading to diminished sensitivity and negative predictive value as a potential neurophysiological ADHD biomarker.DiscussionWhile our study underscores the utility of both TBR and CPT-3 in assessing attentional capacity, their sensitivity in diagnosing ADHD is limited. A comprehensive evaluation, integrating clinical expertise, parental input, and detailed neuropsychometric tests, remains pivotal for a thorough and precise diagnosis of ADHD.
Presence and correlates of autistic traits among patients with social anxiety disorder
Authors: Carpita Barbara , Nardi Benedetta , Bonelli Chiara , Massimetti Enrico , Amatori Giulia , Cremone Ivan Mirko , Pini Stefano , Dell’Osso Liliana 
Published: January 2024

IntroductionDue to their similar behavioral presentation, it can sometimes be challenging to distinguish between a social anxiety disorder (SAD) and the social avoidance that is frequently described in autism spectrum disorder (ASD). Moreover, a growing body of evidences is reporting that a significant proportion of subjects with ASD also meet the requirements for SAD and, vice versa, subjects with SAD tend to exhibit a higher prevalence of autistic traits.AimIn this framework, the current study aims to evaluate prevalence and correlates of autistic traits in a sample of adult subjects diagnosed with SAD and healthy controls (HC), also evaluating which autism spectrum dimensions may statistically predict higher SAD symptoms.Methods56 subjects with a clinical diagnosis of SAD and 56 gender and age matched HC were recruited from the Psychiatric Clinic of the University of Pisa. Subjects were assessed with the SCID-5, the Social Anxiety Spectrum – Short Version (SHY- SV) and the Adult Autism Subthreshold Spectrum (AdAS Spectrum).ResultsSAD group scored significantly higher in all AdAS Spectrum and SHY-SV domains and total score compared to the HC group with no significant gender difference. SHY-SV total and domain scores, were strongly and positively and strongly correlated with all AdAS Spectrum domains and total score. AdAS Spectrum total score and Childhood/Adolescence, Non-Verbal Communication, Empathy and Restricted interests and Rumination domain scores score were significant predictors of higher SHY-SV score.ConclusionOur results confirm the link between SAD and autistic traits also in adult population, describing not only high levels of autistic traits in SAD adults, but also significant correlations between many core features of the two disorders and a predictive role of autistic traits on higher SAD symptoms.
Kinematic performance declines as group size increases during escape responses in a schooling coral reef fish
Authors: Bacchus Monica D. , Domenici Paolo , Killen Shaun S. , McCormick Mark I. , Nadler Lauren E. 
Published: January 2024

IntroductionEscaping predation is essential for species survival, but prey must effectively match their response to the perceived threat imposed by a predator. For social animals, one mechanism to reduce risk of predation is living in larger group sizes, which dilutes each individual's risk of capture. When a predator attacks, individuals from a range of taxa (e.g., fishes, sharks, and amphibians) perform an escape response, to evade the attack.MethodsUsing the schooling coral reef damselfish Chromis viridis, we assess if there is an optimal group size that maximizes both individual escape response performance as well as group cohesion and coordination following a simulated predator attack, comparing schools composed of four, eight, and sixteen fish. The escape response was assessed through simulated predator attacks, measuring escape latency, kinematics (average turning rate, and distance covered), and group dynamics (school cohesion and coordination). The experiments were conducted with varying group sizes to analyze the impact on escape performance and group behavior.ResultsWe found that fish in various group sizes exhibited no difference in their reaction timing to a simulated predator attack (i.e., escape latency), but larger groups exhibited slower kinematics (i.e., lower average turning rate and shorter distance covered during the escape response), potentially because larger groups perceived the predator attack as less risky due to safety in numbers. Both school cohesion and coordination (as measured through alignment and nearest neighbor distance, respectively) declined in the 100 ms after the predator's attack. While there was no impact of group size on alignment, larger group sizes exhibited closer nearest neighbor distances at all times.DiscussionThe findings suggest that larger group sizes in schooling coral reef fish may lead to energy conservation by displaying less costly behavioral responses to predator threats. This potential energy saving could be attributed to a higher threshold of perceived threat required to trigger a rapid escape response in larger groups. The study emphasizes the intricate interplay between individual and collective behaviors in response to predation and sheds light on the nuanced dynamics of group living in the face of predation.