bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies
Authors: Grandjean Philippe , Meddis Alessandra , Nielsen Flemming , Beck Iben H , Bilenberg Niels , Goodman Carly V , Hu Howard , Till Christine , Budtz-Jørgensen Esben 
Published: October 2023

Abstract

Background
Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose–effect relationship in greater detail.

Methods
The OCC contributed 837 mother–child pairs to the total of &gt;1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy. Child IQ was determined at age 7 years using an abbreviated version of the Wechsler Intelligence Scales for Children. Findings from the three cohorts were used to calculate the joint benchmark concentration (BMC) and the lower confidence limit (BMCL) after adjustment for covariables.

Results
In the OCC, urine-fluoride concentrations varied between 0.08 and 3.04 mg/l (median 0.52 mg/l) but were not significantly associated with full-scale IQ at age 7 years (β = 0.08; 95% confidence interval −1.14 to 1.30 for a doubling in exposure). No difference was apparent between boys and girls. In the OCC, the BMC was 0.92 mg/l, with a BMCL of 0.30 mg/l. The joint analysis of all three cohorts showed a statistically significant association between urine-fluoride and IQ, with a BMC of 0.45 mg/l (BMCL, 0.28 mg/l), slightly higher than the BMC previously reported for the two North American cohorts alone.

Conclusions
As the BMCL reflects an approximate threshold for developmental neurotoxicity, the results suggest that pregnant women and children may need protection against fluoride toxicity.
Externalizing Behaviors and Alzheimer’s Disease and Any Dementia: A Multigeneration Cohort Study in Sweden
Authors: Solares Carmen , Zhang Le , Chang Zheng , Andershed Henrik , Persson Jonas , Larsson Henrik 
Published: October 2023

Abstract

Background and Objectives
We examined the extent to which externalizing behaviors such as violent and nonviolent criminal behavior, and substance use disorders (SUD) are associate with the onset of Alzheimer’s disease (AD) and any dementia in prior generations.

Research Design and Methods
A nationwide cohort of 2,463,033 individuals born between 1973 and 1997 (index persons) were linked to their biological relatives (parents, grandparents, and uncles/aunts) using Swedish national registers. Cox regression models were used to examine the association between each measure of externalizing behaviors with AD and any dementia in each of the relative cohorts.

Results
Parents of index persons with externalizing behaviors had an increased risk for AD compared with parents of index persons without externalizing behaviors—nonviolent criminal behavior: Hazard Ratio (HR) = 1.16, 95% Confidence Intervals (CI) 1.10–1.22; violent criminal behavior: HR = 1.32 (95% CI: 1.19–1.45); SUD: HR = 1.28 (95% CI: 1.17, 1.40). The associations attenuated with decreasing familial relatedness. Relatives of individuals with externalizing behaviors compared with relatives of individuals without, showed an increased risk of having both early-onset and late-onset AD but the strength of the associations was higher for early-onset AD than for late-onset AD. A similar pattern of results was observed for the association with any dementia.

Discussion and Implications
Externalizing behaviors are associated with AD and any dementia in prior generations. The associations were stronger for parents in comparison with grandparents and uncles/aunts, suggesting shared familial risks between conditions. This warrants further studies examining common genetic and family-wide environmental factors that may contribute to identifying common underlying mechanisms to the development of externalizing behaviors, AD, and any dementia.
Causal relationship between gastro-esophageal reflux disease and risk of lung cancer: insights from multivariable Mendelian randomization and mediation analysis
Authors: Liu Yi , Lai Hongjin , Zhang Ren , Xia Liang , Liu Lunxu 
Published: October 2023

Abstract

Aim
A recent study has reported that anti-reflux surgery reduced the risk of lung cancer. However, the exact causal association between gastro-esophageal reflux disease (GORD) and lung cancer remains obscure. Therefore, we conducted a multivariable and network Mendelian randomization (MR) study to explore this potential association and mediation effect.

Methods
Independent single nucleotide polymorphisms (SNPs) strongly associated with GORD were selected as instrumental variables (IVs) from the corresponding genome-wide association studies (GWAS). The summary statistics were obtained from the largest GORD GWAS meta-analysis of 367 441 (78 707 cases) European individuals, and the summary statistics of lung cancer and pathological subtypes came from International Lung Cancer Consortium (ILCCO) and FinnGen databases. Univariable and multivariable MR analyses were performed to investigate and verify the causal relationship between genetically predicted GORD and lung cancer. Network MR analysis was conducted to reveal the mediating role of GORD between smoking initiation and lung cancer.

Results
The univariable MR analysis demonstrated that GORD was associated with an increased risk of total lung cancer in both ILCCO [inverse variance weighted (IVW): odds ratio (OR) = 1.37, 95% confidence interval (CI) 1.16–1.62, P = 1.70E-04] and FinnGen database (IVW: OR = 1.25, 95% confidence interval CI 1.03–1.52, P = 2.27E-02). The consistent results were observed after adjusting the potential confounders [smoking traits, body mass index (BMI) and type 2 diabetes] in multivariable MR analyses. In subtype analyses, GORD was associated with lung adenocarcinoma (IVW: OR = 1.27, 95% CI 1.02–1.59, P = 3.48E-02) and lung squamous cell carcinomas (IVW: OR = 1.50, 95% CI 1.22–1.86, P = 1.52E-04). Moreover, GORD mediated 32.43% (95% CI 14.18–49.82%) and 25.00% (95% CI 3.13–50.00%) of the smoking initiation effects on lung cancer risk in the ILCCO and FinnGen databases, respectively.

Conclusion
This study provides credible evidence that genetically predicted GORD was significantly associated with an increased risk of total lung cancer, lung adenocarcinoma and lung squamous cell carcinomas. Furthermore, our results suggest GORD is involved in the mechanism of smoking initiation-induced lung cancer.
Deep Lattice Points in Zonotopes, Lonely Runners, and Lonely Rabbits
Authors: Beck Matthias , Schymura Matthias 
Published: October 2023

Abstract
Let $P \subseteq {\mathbb {R}}^{d}$ be a polytope and let $\textbf {w}$ be an interior point of $P$. The coefficient of asymmetry$\operatorname {ca}(P,\textbf {w}):= \min \{ \lambda \geq 1: \textbf {w} - P \subseteq \lambda (P - \textbf {w}) \}$ of $P$ about $\textbf {w}$ has been studied extensively in the realm of Hensley’s conjecture on the maximal volume of a $d$-dimensional lattice polytope that contains a fixed positive number of interior lattice points. We zero in on the coefficient of asymmetry for lattice zonotopes, that is, Minkowski sums of line segments with integer endpoints. Our main result gives the existence of an interior lattice point for which the coefficient of asymmetry is bounded above by an explicit constant in $\Theta (d \log \log d)$, for any lattice zonotope that has an interior lattice point. Our work is both inspired by and feeds on Wills’ lonely runner conjecture from Diophantine approximation: we make intensive use of a discrete version of this conjecture (which, in fact, has been proved), and reciprocally, we reformulate the lonely runner conjecture in terms of the coefficient of asymmetry for certain lattice zonotopes.
Effectiveness of mRNA COVID-19 Monovalent and Bivalent Vaccine Booster Doses Against Omicron Severe Outcomes Among Adults Aged ≥50 Years in Ontario, Canada: A Canadian Immunization Research Network Study
Authors: Grewal Ramandip , Buchan Sarah A , Nguyen Lena , Nasreen Sharifa , Austin Peter C , Brown Kevin A , Gubbay Jonathan , Lee Nelson , Schwartz Kevin L , Tadrous Mina , Wilson Kumanan , Wilson Sarah E , Kwong Jeffrey C 
Published: October 2023

Abstract
We estimated the effectiveness of booster doses of monovalent and bivalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in Ontario, Canada. Monovalent and bivalent mRNA COVID-19 booster doses provided similar strong initial protection against severe outcomes. Uncertainty remains around waning of protection from these vaccines.
Blood transcriptomic differences in the immune response under stressful environmental according to stocking density in pigs
Authors: Lim Seok-Won , Jeon Jung Hwan , Lim Byeonghwi , Jang Min-Jae , Kim Doo-Hwan , Kim Chan Ho , Kim Jun-Mo 
Published: October 2023

Abstract
The implementation of animal welfare in the pig industry is becoming a global trend, and welfare can be improved through livestock management. In modern and intensive farming systems, it has become important to find a reasonable compromise between stocking density and productivity. The simultaneous detection of behavioral and physiological parameters is helpful when considering welfare levels for stocking density. This study aimed to confirm the effect of stocking density through transcriptome linkage. A comparison of three groups according to stocking density (low density, eight pigs and 1.0 m2 per head; normal density, eight pigs and 0.8 m2 per head; and high density, eight pigs and 0.6 m2 per head) was performed, and their transcriptomic changes were observed using the RNA-Seq method. Differentially expressed genes were identified for each comparison group (low density vs. normal density, 95 upregulated genes and 112 downregulated genes; high density vs. normal density, 133 upregulated genes and 217 downregulated genes; and high density vs. low density, 245 upregulated genes and 237 downregulated genes). Biological mechanisms according to stocking density were identified through functional annotation. T-cell differentiation and immune disease pathway enriched in the high-density group caused immune imbalance through dysregulated T-cell signaling. Moreover, oxidative stress, together with DNA damage, can lead to high susceptibility to disease. Our study confirmed the biological mechanisms through immunological expression patterns according to stocking density. The study results are expected to provide comprehensive insight into systematic operation strategies considering stocking density and biomarkers for use in welfare evaluation.
Contextualizing communication for digital innovation and the future of work
Authors: Fu Jiawei Sophia , Barbour Joshua B 
Published: October 2023

Abstract
Digital innovation is the future of work. The ongoing and interlinked transformation of digital technologies, work, communication, and organizing raises important theoretical questions. Integrating recombination-based innovation theory and institutional theory of communication, this article contributes a novel framework that specifies the theoretical linkages between macro-level institutions and digital innovation: Social actors negotiate tensions arising from multiple institutional logics through (a) attention allocation; (b) sensemaking; and (c) external, boundary-spanning networking. The framework can advance the study of communication by (a) reconciling conflicting and inconclusive empirical findings; (b) targeting research efforts; and (c) responding to critiques of communication scholarship as failing to address social contexts. By focusing on digital innovation and the interplay between societal structures and communicative action in shaping it, this article advances scholarly discussions on the future of work, conceptualizing digital innovation as an institutional as well as communicative accomplishment.
Reading Kant as a radical empiricist: or how to find an orientation for education after progress
Authors: Vlieghe Joris 
Published: October 2023

AbstractThis article deals with the educational challenge of responding to the pending ecological crisis (and many other future apocalyptic scenarios that haunt our imagination). It seems we are living in a time when we have given up on the idea that progress is possible or desirable, and this questions education at its roots. In order to find a proper educational response that befits our time, it is requested that we gain a new sense of orientation (which is no longer aimed at progress). This is an idea I pick up from the recent work of Bruno Latour, which is the focus of the first part of the paper. In the second part, I start fleshing out what this new orientation could look like by turning to the work of Immanuel Kant (usually regarded as one of the most outspoken defenders of education geared to progress). Nonetheless, I try to read Kant against himself, so as to show how orientation can be understood in a non-modernist manner. I connect this in the third part to the radically immanent and empiricist work of William James, and draw out in the final section how a combined reading of Kant and James offers the orientation we need.
Testimonial justice and the voluntarism problem: the virtue of just acceptance
Authors: Kotzee Ben , Sato Kunimasa 
Published: October 2023

ABSTRACT
This paper examines the ‘voluntarism’ challenge for achieving testimonial justice and advocates the virtue of just acceptance of testimony as the right target for efforts to alleviate testimonial injustice. First, we review the credibility deficit case of interpersonal testimonial injustice and explain how the doxastic voluntarism problem poses a challenge to redressing such testimonial injustice. Specifically, the voluntarism problem seems to rule out straightforward control over what and whom people believe; thus, the solution to the problem of testimonial injustice cannot lie in voluntarily self-correcting unjust credibility judgements and replacing them with just testimonial beliefs. Second, we identify three distinctive characteristics of acceptance of testimony, as distinct from belief, and argue that, while it might be difficult to form credibility judgements completely voluntarily, it is easier to control one’s attitude of acceptance towards a speaker’s testimony. We hold that shifting focus from testimonial belief to acceptance can overcome the problem of (synchronic) involuntarism about testimonial belief. Third, we articulate a vision of a virtue of just acceptance of testimony that can move a hearer to collect the right evidence to reliably find the answer to whether a speaker’s testimony is true. Finally, we demonstrate that encouraging people to take a virtuous attitude of just acceptance towards a speaker’s testimony forms the basis of a remedial vision of education that can play a distinctive role in fostering the virtue of just acceptance aimed at testimonial justice.
Mixed primary and secondary vaginal calculi: a case report
Authors: Alhajress Ghassan , Albqami Nasser , Nazer Ahmed I , Alfraidi Omar B , Balaraj Faisal Khalid , Alsaghyir Abdullah , Ghazwani Yahya 
Published: October 2023

Abstract
Vaginal calculi are classified according to the pathogenesis of calculus formation. Primary and secondary vaginal calculi. In this article, we present an interesting case that we believe to be a mixed primary and secondary vaginal calculi in which both originated as a result of a vesicovaginal fistula (VVF) and stitches found in the vagina. Although vaginal calculi are a rare disease, a high index of suspicion is needed, especially in patients with a history of gynecological procedures. Since the high recurrence rate of VVF along with its complications, more frequent follow-up and physical examination are required to avoid the recurrence of the disease.
Identifying social norm violation in movie plots: from Borat to American Pie
Authors: Neuman Yair , Cohen Yochai , Yin Wenpeng 
Published: October 2023

Abstract
The violation of social norms in TV and cinema is a well-known source of humor and catharsis, and researchers in digital humanities may benefit from the automatic identification of social norm violations. In this article, we introduce a novel methodology for identifying and analyzing the violation of social norms in textual data and illustrate it in the analysis of movie plots. The methodology leans on zero-shot classification, specifically relevant when massive, labeled datasets are unavailable. We test our methodology and provide researchers with (1) a theoretically grounded tool for screening textual data for social norm violation and with new datasets that include (2) 6,806 embarrassing situations from movie plots and their hypothesized violated norm and (3) 3,059 movie plots with their average embarrassment score.
Should We Use Rifampicin in Periprosthetic Joint Infections Caused by Staphylococci When the Implant Has Been Exchanged? A Multicenter Observational Cohort Study
Authors: Kramer Tobias Siegfried , Soriano Alex , Tedeschi Sarah , Chen Antonia F , Tattevin Pierre , Senneville Eric , Gomez-Junyent Joan , Birlutiu Victoria , Petersdorf Sabine , de Brito Vicens Diaz , Gonzalez Ignacio Sancho , Belden Katherine A , Wouthuyzen-Bakker Marjan 
Published: October 2023

Abstract

Background
Previous studies demonstrated the efficacy of a rifampicin-based regimen in the treatment of acute staphylococcal periprosthetic joint infections (PJIs) treated with surgical debridement. However, evidence is lacking to support the use of rifampicin in cases where the implant is exchanged during revision.

Methods
We included all consecutive cases of staphylococcal PJIs treated from January 2013 to December 2018 with revision surgery in this international, retrospective, multicenter observational cohort study. PJI was defined according to the European Bone and Joint Infection Society diagnostic criteria. A relapse or reinfection during follow-up, the need for antibiotic suppressive therapy, the need for implant removal, and PJI-related death were defined as clinical failure. Cases without reimplantation or with follow-up &lt;12 months were excluded.

Results
A total of 375 cases were included in the final analysis, including 124 1-stage exchanges (33.1%) and 251 2-stage exchanges (66.9%). Of those, 101 cases failed (26.9%). There was no statistically significant difference in failure of patients receiving rifampicin (22.5%, 42/187) and those not receiving rifampicin (31.4%, 59/188; P = .051). A subanalysis of chronic PJIs treated by 2-stage exchange arthroplasty demonstrated a lower failure rate in cases treated with rifampicin (15%) compared with the no-rifampicin group (35.5%; P = .005). In this subgroup, the use of rifampicin and an antibiotic holiday of &gt;2 weeks were independent predictors of clinical success (odds ratio [OR], 0.36; 95% CI, 0.15–0.88; and OR, 0.19; 95% CI, 0.04–0.90; respectively).

Conclusions
Combination treatment with rifampicin increases treatment success in patients with chronic staphylococcal PJI treated with 2-stage exchange arthroplasty.
Long noncoding RNA TRABA suppresses β-glucosidase-encoding BGLU24 to promote salt tolerance in cotton
Authors: Cui Changjiang , Wan Hui , Li Zhu , Ai Nijiang , Zhou Baoliang 
Published: October 2023

Abstract
Salt stress severely damages the growth and yield of crops. Recently, long noncoding RNAs (lncRNAs) were demonstrated to regulate various biological processes and responses to environmental stresses. However, the regulatory mechanisms of lncRNAs in cotton (Gossypium hirsutum) response to salt stress are still poorly understood. Here, we observed that a lncRNA, trans acting of BGLU24 by lncRNA (TRABA), was highly expressed while GhBGLU24-A was weakly expressed in a salt-tolerant cotton accession (DM37) compared to a salt-sensitive accession (TM-1). Using TRABA as an effector and proGhBGLU24-A-driven GUS as a reporter, we showed that TRABA suppressed GhBGLU24-A promoter activity in double transgenic Arabidopsis (Arabidopsis thaliana), which explained why GhBGLU24-A was weakly expressed in the salt-tolerant accession compared to the salt-sensitive accession. GhBGLU24-A encodes an endoplasmic reticulum (ER)–localized β-glucosidase that responds to salt stress. Further investigation revealed that GhBGLU24-A interacted with RING-type E3 ubiquitin ligase (GhRUBL). Virus-induced gene silencing (VIGS) and transgenic Arabidopsis studies revealed that both GhBGLU24-A and GhRUBL diminish plant tolerance to salt stress and ER stress. Based on its substantial effect on ER-related degradation (ERAD)–associated gene expression, GhBGLU24-A mediates ER stress likely through the ERAD pathway. These findings provide insights into the regulatory role of the lncRNA TRABA in modulating salt and ER stresses in cotton and have potential implications for developing more resilient crops.
The social media discourse of engaged partisans is toxic even when politics are irrelevant
Authors: Mamakos Michalis , Finkel Eli J 
Published: October 2023

Abstract
Prevailing theories of partisan incivility on social media suggest that it derives from disagreement about political issues or from status competition between groups. This study—which analyzes the commenting behavior of Reddit users across diverse cultural contexts (subreddits)—tests the alternative hypothesis that such incivility derives in large part from a selection effect: Toxic people are especially likely to opt into discourse in partisan contexts. First, we examined commenting behavior across over 9,000 unique cultural contexts (subreddits) and confirmed that discourse is indeed more toxic in partisan (e.g. r/progressive, r/conservatives) than in nonpartisan contexts (e.g. r/movies, r/programming). Next, we analyzed hundreds of millions of comments from over 6.3 million users and found robust evidence that: (i) the discourse of people whose behavior is especially toxic in partisan contexts is also especially toxic in nonpartisan contexts (i.e. people are not politics-only toxicity specialists); and (ii) when considering only nonpartisan contexts, the discourse of people who also comment in partisan contexts is more toxic than the discourse of people who do not. These effects were not driven by socialization processes whereby people overgeneralized toxic behavioral norms they had learned in partisan contexts. In contrast to speculation about the need for partisans to engage beyond their echo chambers, toxicity in nonpartisan contexts was higher among people who also comment in both left-wing and right-wing contexts (bilaterally engaged users) than among people who also comment in only left-wing or right-wing contexts (unilaterally engaged users). The discussion considers implications for democratic functioning and theories of polarization.