bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States
Authors: Schold Jesse D. , Conzen Kendra D. , Cooper James , Arrigain Susana , Lopez Rocio , Mohan Sumit , Husain Syed Ali , Huml Anne M. , Kennealey Peter T. , Kaplan Bruce , Pomfret Elizabeth A. 
Published: February 2024

Key Points

Nationally, 41% of kidney transplant candidates consented to receive high–Kidney Donor Profile Index (KDPI) donor offers in the United States.There was wide variation in consent proportion for high-KDPI donors on the basis of individual characteristics and transplant centers.Consent for high-KDPI kidneys was associated with 15% higher adjusted rates of deceased donor transplantation.

Background
Despite known benefits of kidney transplantation, including transplantation from donors with increased risk factors, many waitlisted candidates die before transplantation. Consent to receive donor kidneys with lower expected survival (e.g., Kidney Donor Profile Index [KDPI] >85%) is typically obtained at waitlist placement. The presumed benefit of consent to receive high-KDPI donor kidneys is higher likelihood and timeliness of donor offers for transplantation. However, the specific effect of consent on access to transplantation is unclear. Our aims were to evaluate the characteristics of candidates consenting to high-KDPI donor kidneys and the likelihood of receiving a deceased donor transplant over time on the basis of consent.

Methods
We used national Scientific Registry of Transplant Recipients data between 2015 and 2022 (n=213,364). We evaluated the likelihood of consent using multivariable logistic models and time to deceased donor transplant with cumulative incidence plots accounting for competing risks and multivariable Cox models.

Results
Overall, high-KDPI consent was 41%, which was higher among candidates who were older, were Black or Hispanic, had higher body mass index, had diabetes, had vascular disease, and had 12–48 months prelisting dialysis time, with significant center-level variation. High-KDPI consent was associated with higher rates of deceased donor transplant (adjusted hazard ratio=1.15; 95% confidence interval, 1.13 to 1.17) with no difference in likelihood of deceased donor transplant from donors with KDPI <85%. The effect of high-KDPI consent on higher rates of deceased donor transplantation was higher among candidates older than 60 years and candidates with diabetes and variable on the basis of center characteristics.

Conclusions
There is significant variation of consent for high-KDPI donor kidneys and higher likelihood of transplantation associated with consent.
Korelasi Karbon Monoksida dan Derajat Rokok dengan Fungsi Paru pada Pengemudi Ojek Online
Authors: Khairani Rita , Putri Mustika Anggiane , Setyaningrum Dyah Ayu Woro 
Published: February 2024

Latar Belakang
Asap rokok merupakan sumber utama pajanan terhadap karbon monoksida (CO) selain polusi udara. Saat asap rokok terinhalasi, karbon monoksida akan diabsorpsi melalui paru, masuk ke dalam aliran darah kemudian akan berikatan dengan hemoglobin untuk membentuk karboksi – hemoglobin (COHb) yang kadarnya dalam darah dapat diukur sebagai marker absorpsi asap rokok. Baik rokok atau CO dapat mempengaruhi fungsi paru, setelah merokok maka kadar CO dalam darah akan meningkat dan fungsi paru akan menurun secara bermakna.
Metode
Penelitian ini menggunakan metode observasional analitik dengan desain potong lintang dengan besar sampel 99 responden. Pengambilan data pada bulan September-Desember 2022 dengan menggunakan kuesioner Indeks Brinkman, Fagerstrom Test for Nicotine Dependence (FTND), pengukuran CO ekspirasi dan pemeriksaan spirometri
Hasil
Sebanyak 47.5% responden memiliki kadar CO ekspirasi sebesar 0-6 ppm yang masih berada pada zona hijau, 77.8% responden merokok, 57.6% memiliki skor FTND 0-2, sebanyak 51.5% mengalami gangguan restriksi dan 79.5% responden mengalami gangguan obstruksi saluran napas. Kadar CO ekspirasi berkorelasi erat dengan indeks Brinkman (r=0.654, p=0.000), dan berkorelasi sedang bermakna dengan skor FTND (r=0.544, p=0.000). Tidak ada korelasi kadar CO ekspirasi, indeks Brinkman dan ketergantungan terhadap nikotin dengan fungsi paru.
Kesimpulan
kadar CO ekspirasi berkorelasi erat dengan rokok dan ketergantungan nikotin tetapi tidak berkorelasi dengan fungsi paru.
Pencucian Uang Lintas Negara dengan Menggunakan Cryptocurrency: Perspektif Bentuk Kerjasama Penanganan Antar Negara
Authors: Darojat Mohammad Irfaul , Yahya Amirudin , Wahyudi Dimas , Firdaus Gigih Reksa Yudha 
Published: February 2024

Cryptocurrency sebagai salah satu bentuk inovasi teknologi dalam bentuk mata uang digital dapat menggantikan mata uang konvensional. Cryptocurrency yang terdapat teknologi blokchaine sebagai fitur keamanan dan kemudahan yang tentunya dapat memberikan dampak yang positif, juga timbul dampak negatif yang diakibatkan dengan adanya mata uang digital ini. Salah satu celah yang dimanfaatkan banyak orang dengan adanya fitur keamanan data pada Cryptocurrency adalah sebagai alat untuk melakukan pencucian uang. Apalagi setiap orang memiliki akses dalam menggunakan cryptocurrency sebagai alat pembayaran maupun alat investasi. Namun dalam kemudahan tersebut terdapat persoalan yang menjadi kegelisahan banyak pihak terutama pemerintah dari berbagai negara yang tentunya cukup kesulitan dalam melacak setiap tindakan pencucian uang yang menggunakan Cryptocurrency ini. Di Indonesia sendiri telah mengaturnya dalam UU No. 8 Tahun 2010 Tentang Pencegahan dan Pemberantasan Tindak Pidana Pencucian Uang, sehingga setiap tindak kejahatan pencucian uang dapat di jerat dengan undang-undang tersebut yang mana juga menjadi dasar hukum dalam penanganan penindakan kasus tersebut dengan melibatkan negara lain atau instansi lain sebab kejahatan pencucian uang dapat menjadi suatu kejahatan Internasional. Adapun tujuan artikel ini adalah untuk mengetahui bentuk regulasi tindak pidana pencucian uang lintas negara khususnya dengan menggunakan cryptocurrency dan juga bentuk-bentuk kerjasama yang dapat dilakukan dalam menangani kasus tersebut. Metode penelitian yang digunakan dalam penelitian ini adalah Library Research atau sering dikenal dengan penelitian hukum normatif. Hasil yang didapatkan menunjukkan bagaimana bentuk regulasi di Indonesia dan beberapa negara mengenai tindak pidana pencucian uang dengan cryptocurrency serta mengetahui bagaimana urgensitas penanganan tindak pidana pencucian uang dengan cryptocurrency dan bentuk regulasi bantuan Internasional yang dapat diperoleh dalam menangani kasus tersebut.
Delik Suap dan Gratifikasi dalam Tindak Pidana Korupsi: Studi Kasus Putusan Hakim dalam Praktik Penegakan Hukum
Authors: Kahar Muhammad Paeway Ebiem , Rahmatullah Khoirul Lukman , Yuris Faza , Azizah Ainul , Prihatmini Sapti 
Published: February 2024

ABSTRAK
Praktik gratifikasi dan suap yang dilakukan oleh pejabat negara merupakan suatu masalah yang saat ini dihadapi bangsa Indonesia. Sepanjang ini perumusan peraturan mengenai perbuatan gratifikasi dan suap dibedakan berdasarkan adanya yang diperjanjikan. Artinya suap dapat berupa janji, sedangkan gratifikasi merupakan pemberian dalam arti luas dan bukan janji. Melalui putusan nomor Nomor 68/Pid.Sus-TPK/2018/PN.Jkt.Pst perlu dipahami lebih lanjut bagaimana putusan tersebut memaknai suap dan gratifikasi dalam konteks tindak pidana korupsi. Penelitian ini bertujuan untuk menggali pemaknaan dan interpretasi hukum terkait suap dan gratifikasi dalam putusan pengadilan tersebut. Metode yang digunakan adalah analisis isi terhadap putusan pengadilan, dengan mengidentifikasi argumen hukum yang digunakan, pendekatan hukum yang diadopsi, dan pertimbangan yang diberikan oleh hakim. Hasil analisis menunjukkan bahwa putusan pengadilan tersebut memberikan pengertian yang jelas mengenai suap dan gratifikasi sebagai tindak pidana korupsi. Dalam konteks ini, suap diartikan sebagai pemberian atau janji pemberian kepada pejabat publik dengan tujuan mempengaruhi keputusan atau tindakan pejabat tersebut. Sementara itu, gratifikasi diartikan sebagai pemberian hadiah atau imbalan kepada pejabat publik sebagai bentuk penghargaan atau imbalan atas tindakan atau keputusan yang telah diambil.
Strategi Pengembangan Rantai Pasok (Supply Chain) Ikan Tuna Menggunakan Model SCOR & SWOT Di TPI Tenda Gorontalo
Authors: Bahnan Wahyuni A 
Published: February 2024

<p>Letak Provinsi Gorontalo sangat strategis, karena diapit oleh dua perairan, yaitu Teluk Tomini di sebelah Selatan dan Laut Sulawesi di sebelah Utara. Provinsi Gorontalo mempunyai potensi kelautan dan perikanan yang cukup besar, Pengelolaan rantai pasok pada perikanan komoditas ikan tuna segar sangat diperlukan, karena komoditas tersebut memiliki nilai ekonomis, permintaan tinggi, dan manfaat yang tinggi bagi nelayan dan masyarakat. Manajemen rantai pasok di TPI Tenda Gorontalo masih belum maksimal, seperti pada aktivitas bongkar muat ikan yang masih manual, kebutuhan es untuk melaut masih belum terpenuhi serta kenaikan/kelangkaan BBM. Berdasarkan permasalahan tersebut maka dibutuhkan pengelolaan yang efektif dan efisien untuk diterapkan di TPI Tenda Gorontalo. Salah satunya pengelolaan rantai pasok (<em>supply chain</em>) ikan tuna. Tujuan penelitian ini yaitu untuk mengetahui aliran dan kinerja rantai pasok ikan tuna di TPI Tenda Gorontalo serta merumuskan strategi alternatif yang bisa diterapkan untuk pengembangan rantai pasok ikan tuna. Metode penelitian yang digunakan pada penelitian ini yaitu metode SCOR dan SWOT. Hasil yang diperoleh menggunakan metode SCOR didapatkan bahwa nilai kinerja rantai pasok pada metrik reliabilitas yaitu 80%, pada metrik responsivitas yaitu 2 – 12 hari, pada metrik fleksibilitas rantai pasok yaitu 1 – 5 hari, untuk metrik <em>cost</em> yaitu ± 15 juta, pada metrik siklus <em>Cash-to-cash</em> yaitu 1 – 2 hari. Metode SWOT menghasilkan nilai skor faktor internal yaitu 3,32 sedangkan faktor eksternal yaitu 3,38.</p>
Pemilihan Supplier dengan Metode Step-Wise Weight Assessment Ratio Analysis dan Extended Promethee II
Authors: Hidayat Arief , Garside Annisa Kesy , Saputro Thomy Eko 
Published: February 2024

<span lang="EN-US">Pertumbuhan bisnis dalam bidang konstruksi di Indonesia berkembang pesat, sehingga membuat persaingan bisnis bertambah khususnya Kalimantan Timur. </span><span lang="ES">Salah satu kegiatan yang penting bagi perusahaan konstruksi adalah melakukan pengadaan persediaan bahan baku. Ketersediaan bahan baku merupakan faktor penting yang harus diperhatikan agar proses produksi dapat berjalan dengan baik. </span><span lang="EN-US">Untuk menjaga kelangsungan proses produksi, perusahaan bekerjasama dengan supplier bahan baku yang tepat agar dapat menyediakan bahan baku saat dibutuhkan. </span><span lang="ES">Tujuan dari penelitian ini adalah mengidentifikasi kriteria dan sub kriteria yang tepat dan menentukan supplier terbaik yang dapat diterapkan segera oleh PT Balikpapan Ready Mix Pile. Hasil dari penelitian ini terdapat 6 kriteria dan 15 sub kriteria terpilih untuk menentukan supplier yang tepat. Metode Step-Wise Weight Assessment Ratio Analysis digunakan untuk menentukan bobot kriteria dan sub kriteria. Sub kriteria paling penting dalam pemilihan supplier adalah kualitas bahan dengan nilai bobot sebesar 0,2639. Selanjutnya, hasil pengolahan data dengan Extended Promethee II diperoleh alternatif supplier terbaik adalah alternatif A2 dengan nilai prioritas sebesar 0,2692</span>
Exploring Critical Factors Influencing the Resilience of the Prefabricated Construction Supply Chain
Authors: Ma Li , Liu Tianyang , Fu Hongwei 
Published: February 2024

Abstract

Prefabricated construction has less environmental pollution, less resource consumption, and high productivity. This new construction model is an important tool for the construction industry to achieve sustainable development. However, disruptions in the prefabricated construction supply chain (PCSC) frequently occur in practice, which seriously reduces the performance of prefabricated building projects. Improving the resilience of the prefabricated construction supply chain (RPCSC) is an urgent problem to be solved. This study first identified the factors influencing the RPCSC through a comprehensive literature review. Next, 13 experts were invited to summarize and integrate these factors, and 11 concepts were obtained. Finally, the fuzzy cognitive maps method is applied to evaluate the impact of these concepts on the RPCSC and the interaction between them. The results show that the main factors are relationship quality of members, laws and regulations, information exchange/analysis, Professional management personnel/Labor quality, and R&D. Moreover, this study reveals the effect of these factors individually or synergistically influencing the RPCSC. This study provides valuable insights for governments and members of the prefabricated construction supply chain. The related findings can help reduce the risk of disruption in the prefabricated supply chain, improving the productivity and low-carbon performance of prefabricated construction.
RETRACTED: Advances in nanosensor strategies for on-site detection of pesticide residues in agricultural products
Authors: Dixit Aishwarya , Kumar Nishant , Bajpai Vivek K. , Cho Youngjin , Yang Yu-jeong , Upadhyay Ashutosh , Huh Yun Suk , Shukla Shruti 
Published: February 2024

Abstract

The authors have requested the removal of their preprint from Research Square, due to current circumstances that make preprinting challenging at this time. The author's request does not imply errors or misconduct.
Intelligent Guide RNA: Harboring Dual Toe-Hold Switches for Luciferase Reporter Modulation in the Presence of Trigger RNA
Authors: Hosseinkhani Saman , Hashemabadi Mohammad , Sasan Hossein , Sadeghizadeh Majid 
Published: February 2024

Abstract

The CRISPR system has been extensively utilized in various aspects of molecular biology for over a decade. However, its continuous activity can result in undesirable effects. Nevertheless, implementing programmable CRISPR/Cas9 function using nano-device mediation can effectively mitigate these side effects. By integrating RNA-sensing platforms, into the CRISPR system, it has been transformed into a powerful tool for processing internal cell information and modulating gene activity.
Here, an Intelligent guide RNA (IngRNA), a cis-repressed gRNA synthetic circuit which enables efficient recognition of arbitrary stimulatory RNA was developed. In this system, the presence of cognate trigger RNA promotes precise binding to the first toe-hold site, subsequently exposes the second toe-hold site. The connection between the 5' end of platform and the second toe-hold site facilitates gRNA activity to target gene of interest. Activating this genetic logic circuit in response to specific cellular conditions holds great promise as a platform for synthetic biology.
Risk factors for severe and fatal childhood unintentional injury: A systematic review protocol
Authors: Beaulieu Emilie , Herrera Norma Maria Perez , Boutin Amelie 
Published: February 2024

Abstract

Background
Unintentional injuries are a leading cause of death among children aged 1–19 years worldwide. Systematic reviews assessing various risk factors for different childhood injuries have been published previously. However, most of the related literature does not distinguish minor from severe or fatal injuries. This study aims to describe and summarize the current knowledge on the determinants of severe and fatal childhood unintentional injuries and to discuss the differences between risk factors for all injuries (including minor injuries) and severe and fatal injuries. The study also aims to quantify the reduction in child injuries associated with a reduction in exposure to some of the identified risk factors in the Canadian population.
Methods
A systematic review and meta-analysis will be conducted by searching Medline, Embase, CINAHL and Web of Science. Observational and experimental cohort studies assessing children and adolescents aged ≤ 19 years old and determinants of severe and fatal unintentional injury, such as personal behaviors, family and environmental characteristics, and socioeconomic and geographic context will be eligible. The main outcome will be a composite of any severe or fatal unintentional injuries (including burns, drowning, transport-related injuries and falls). Any severity measurement scale will be accepted as long as severe cases require at least one hospital admission. Two authors will independently screen for inclusion, extract data and assess the quality of the data using the Cochrane ROBINS-E tool. Meta-analysis will be performed using random effects models. Subgroup analyses will examine age subgroups and high vs low-income countries. Sensitivity analysis will be conducted after restricting analyses to studies with a low risk of bias. Attributable fractions will be computed to assess the burden of identified risk factors in the Canadian population.
Discussion
Given the numerous determinants of child injuries and the challenges that may be involved in identifying which individuals should be prioritized for injury prevention efforts, this evidence may help to inform the identification of high-risk children and prevention interventions, considering the disproportionate consequences of severe and fatal injuries. This evidence may also help pediatric healthcare providers prioritize counseling messaging.
Systematic review registration: PROSPERO # CRD42023493322
Predicting invasive disease-free survival in ER-positive, HER2-negative early breast cancer using the PAM50 risk-of-recurrence score: a retrospective analysis using single-center long-term follow-up data of Japanese patients with breast cancer
Authors: Higami Akane , Takada Masahiro , Kawaguchi-Sakita Nobuko , Kawashima Masahiro , Kawaguchi Kosuke , Yamaguchi Ayane , Takeuchi Yasuhide , Yamada Yosuke , Toi Masakazu Kawaguchi 
Published: February 2024

Abstract

Background
The prognostic value of the risk-of-recurrence (ROR) score calculated using PAM50 has been validated using clinical trials and patient cohorts. This study aimed to investigate the prognostic value of the PAM50 ROR score in Japanese patients with early breast cancer using long-term follow-up data.
Methods
We enrolled postmenopausal patients with ER-positive, HER2-negative, stage I–II breast cancer who had undergone surgery at the Kyoto University Hospital between 2014 and 2018. The intrinsic subtype and ROR score were calculated using PAM50. The primary endpoint was invasive disease-free survival (IDFS).
Results
We enrolled 147 patients, of whom 48 (33%) patients had node-positive disease, and 37 (25%) had received neoadjuvant or adjuvant chemotherapy. The proportions of intrinsic subtypes for luminal A, luminal B, HER2-enriched, and basal-like subtypes were 67%, 27%, 3%, and 2%, respectively. The median follow-up duration was 8.4 (range: 6.3–10.0) years, and 21 IDFS events were observed. Based on the ROR score, 37%, 33%, and 30% of the patients were classified as low-, intermediate-, and high-risk, respectively. Patients in the high-risk group had a significantly worse 8-year IDFS rate than those in the low-to-intermediate-risk groups (75.7% vs. 91.6%, p = 0.04). The same trend was observed in patients with and without neoadjuvant or adjuvant chemotherapy.
Conclusions
Using long-term follow-up data, this study showed that the ROR score can predict the prognosis of ER-positive, HER2-negative early breast cancer in Japanese postmenopausal patients. Further investigations are required to confirm the prognostic value of the ROR score in Asian populations.
Variational Tensor Neural Networks for Deep Learning
Authors: Jahromi Saeed S. , Orús Román 
Published: February 2024

Abstract

Deep neural networks (NNs) encounter scalability limitations when confronted with a vast array of neurons, thereby constraining their achievable network depth. To address this challenge, we propose an integration of tensor networks (TN) into NN frameworks, combined with a variational DMRG-inspired training technique. This inturn, results in a scalable tensor neural network (TNN) architecture capable of efficient training over a large parameter space. Our variational algorithm utilizes a local gradient-descent technique, enabling manual or automatic computation of tensor gradients, facilitating design of hybrid TNN models with combined dense and tensor layers. Our training algorithm sheds light on the entanglement structure of the tensorized trainable weights, while also illuminating the expressive power of the TNN as a quantum neural state. We validate the accuracy and efficiency of our method by designing TNN models for regression and classification tasks on diverse datasets. Furthermore, we delve into the expressive power of our algorithm, drawing upon the entanglement structure of the neural network.
Spinal anesthesia and multimodal analgesia using erector spinae plane block and magnesium sulfate in a patient with systemic sclerosis undergoing laminectomy: a case report
Authors: Shakeri Alireza , Behjati Jina 
Published: February 2024

Abstract
Background: The erector spinae plane block (ESPB) is a relatively novel regional anesthesia technique that has gained popularity for various surgical procedures, including spine surgery.
Case presentation: We describe the successful application of spinal anesthesia (SA), ESPB, and magnesium sulfate in a female patient with a history of systemic sclerosis and pulmonary fibrosis undergoing laminectomy.
Conclusions: Our application of this multimodal anesthesia technique resulted in efficient pain management and a complication-free perioperative course despite significant risks associated with the patient’s underlying condition.
Dual-catalytic structural isomerisation as a route to
α-arylated ketones
Authors: Teskey Christopher , Lunic Danijela , Vystavkin Nikita 
Published: February 2024

Abstract
Isomerisation reactions provide streamlined routes to organic compounds which are otherwise hard to directly synthesise. The most common forms are positional, geometrical or stereochemical isomerisations which involve the relocation of a double bond or a change in relative location of groups in space. In contrast, far fewer examples of structural (or constitutional) isomerisation exist where the connectivity between atoms is altered. The development of platforms capable of such rearrangement poses a unique set of challenges because chemical bonds must be selectively cleaved, and new ones formed without overall addition or removal of atoms. Here, we show that a dual catalytic system can enable the structural isomerisation of readily available allylic alcohols into more challenging-to-synthesise α-arylated ketones. Key to our strategy is the combination of a cobalt catalyst and photocatalyst under reductive, protic conditions which allows intermediates to propagate catalytic turnover. By providing an unusual disconnection to structural motifs which are difficult to access through direct arylation, we anticipate inspiring other advanced catalytic isomerisation strategies that will further retrosynthetic logic for complex molecule synthesis.