bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge-aware progressive clustering for social image
Authors: Li Mingyuan , Dong Yadong , Liu Dongqing , Yan Xiaoqiang , Yue Caitong , Ren Xiangyang 
Published: October 2023

AbstractSocial image data refer to the annotated image with tags in social media, in which the tags are always labeled by users. Integrating the visual and textual information of social image can obtain accurate and comprehensive feature and improve clustering performance. However, the heterogeneous gap between tags and images makes it difficult to reasonably organize the social images. In addition, the tags are often sparse and incomplete due to personal preference and cognition differences of users. To solve these problems, we propose a novel knowledge-aware progressive clustering (KAPC) method, which employs human knowledge to guide the cross-modal clustering of social images. Firstly, we design a dual-similarity semantic expansion strategy to complement the sparse tags with human knowledge, which constructs a more complete semantic similarity matrix for tags through knowledge graphs. Secondly, we define an objective function based on information theory to bridge the heterogeneous gap, which align inter-modal cluster distribution to explore the correlation between visual and textual information. Finally, a progressive iteration method is designed to make the two modalities guide each other and obtain better performance of social image clustering. Extensive experiments on four social image datasets verify the effectiveness of the proposed KAPC method.
Geomechanical Properties of Clay Stabilised with Fly Ash-Based Geopolymer Subjected to Long-Term Sulfate Attack
Authors: Abdullah Hayder H. , Shahin Mohamed A. 
Published: October 2023

AbstractFly ash-based geopolymers have emerged as an eco-friendly alternative binder compared to conventional Portland cement for soil stabilisation. However, the gap in the current literature is the lack of a comprehensive study regarding the geomechanical behaviour of fly ash geopolymer-treated clay subjected to long-term sulfate attack, particularly in terms of potential ettringite formation and the corresponding impact on cementitious soil structure. The goal of this paper is to address this knowledge gap and provide a comprehensive study to fulfil it. In this work, sulfate attack was simulated by submerging geopolymer-treated clay specimens in two distinct sulfate-based solutions (i.e., sodium and magnesium), for one year. Subsequently, comparative analyses of the geomechanical and microstructural changes in geopolymer-treated clay under various curing conditions were conducted through unconfined compressive strength, direct shear, volume change and microscopic tests. The findings indicate that the addition of geopolymer for the stabilisation of clay soil significantly improves soil strength without affecting the soil volumetric response. Although the clay used exhibited similar qualitative stress–strain behaviour across all simulated attacks, notable quantitative differences emerged in the peak strength, stiffness and shear strength parameters. Such discrepancies can primarily be attributed to the varying buffering capacities (i.e., pH changes associated with acidification) of the sulfate solutions and the subsequent residual pH, cementitious product formation and strength enhancement within the treated clay.
Decentralizing the lightning network: a score-based recommendation strategy for the autopilot system
Authors: Mahdizadeh Mohammad Saleh , Bahrak Behnam , Sayad Haghighi Mohammad 
Published: October 2023

AbstractThe fundamental objective of the Lightning Network is to establish a decentralized platform for scaling the Bitcoin network and facilitating high-throughput micropayments. However, this network has gradually deviated from its decentralized topology since its operational inception, and its resources have quickly shifted towards centralization. The evolution of the network and the changes in its topology have been critically reviewed and criticized due to its increasing centralization. This study delves into the network’s topology and the reasons behind its centralized evolution. We explain the incentives of various participating nodes in the network and propose a score-based strategy for the Lightning Autopilot system, which is responsible for automatically establishing new payment channels for the nodes joining the network. Our study demonstrates that utilizing the proposed strategy could significantly aid in reducing the network’s centralization. This strategy is grounded in qualitative labeling of network nodes based on topological and protocol features, followed by the creation of a scoring and recommendation model. Results of the experiments indicate that in the evolved network using the proposed strategy, concentration indicators such as the Gini coefficient can decrease by up to 17%, and channels ownership of the top 1% of hubs decrease by 27% compared to other autopilot strategies. Moreover, through simulated targeted attacks on hubs and channels, it is shown that by adopting the proposed strategy, the network’s resilience is increased compared to the existing autopilot strategies for evolved networks. The proposed method from this research can also be integrated into operational Lightning clients and potentially replace the current recommendation methods used in Lightning Autopilot.
Psychedelics action and schizophrenia
Authors: Maćkowiak Marzena 
Published: October 2023

AbstractPsychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT)2A receptor activation and induce several behavioral responses. They are of special interest because of their positive effects on neuropsychiatric disorders (depression and posttraumatic stress disorder). However, several findings revealed that some psychedelic actions are similar to symptoms observed in schizophrenia (psychosis, sensorimotor gating impairments, attention, and working memory deficits) which might limit their clinical applications. Psychedelics activate some neurotransmitters, i.e., serotonergic, and glutamatergic, that are also impaired in schizophrenia. Therefore, the neurobiological background of psychedelics and schizophrenia is partially similar. Another important aspect to discuss is the perspective of using psychedelics in schizophrenia therapy. Postmortem studies showed a loss of synapses in schizophrenia, and the positive effects of psychedelics on neuroplasticity (synaptogenesis, neurogenesis, and neuritogenesis) might be essential in the context of schizophrenia therapy. However, because of psychedelics' psychotic action, the recommended doses of psychedelics in schizophrenia treatment are not established, and subpsychedelic dosing or microdosing are considered. Exploratory studies are needed to determine the tolerability of treatment and appropriate dosing regimen. Another therapeutic option is using non-hallucinogenic psychedelic analogs that also induce neuroplastic outcomes but do not have psychotogenic effects. Further preclinical and clinical studies are needed to recognize the potential effectiveness of 5-HT2A agonists in schizophrenia therapy.
Promoting industrial symbiosis and circularisation by optimising waste-based briquette shelf life
Authors: Ossei-Bremang Rejoice Ntiriwaa , Adjei Eunice Akyereko , Kemausuor Francis , Gyenin Eric Kwesi 
Published: October 2023

AbstractThe fusion of the circular economy and industrial symbiosis has several advantages from an economic and developmental standpoint. Cooking energy security issues in Africa can partly be solved by the utilization of waste resources in energy technology decisions such as briquette. However, one of the limitations associated with waste-based briquettes has been identified as a reduction in efficiency when stored for a long period of time under varied storage conditions. The aim of this study was to ascertain the effects of storage time and exposure on the calorific value and mechanical characteristics of a waste-based composite briquette made from oil palm shell and decanter cake after 180 days of storage. The calorific value decreased by 12.99% and 31.40%, respectively, for sealed packaged storage and open-air storage. On the 180th day of the experiment, the packaged storage and the open-air storage registered 1000.48 kg/m3 and 870 kg/m3, 72.34% and 100%, 712% and 895%, and 118% and 143% for relaxed densities, shatter indices, resistance to impact, and hygroscopic properties respectively. Manufacturers within West Africa can adopt the findings in this study as a guide for their processes.
Influence of additives on strength enhancement and greenhouse gas emissions of pre-cast lime-based construction products
Authors: O’Flaherty F. J. , Khalaf F. J. , Starinieri V. 
Published: October 2023

AbstractStrength properties of laboratory scale lime-based samples enhanced with additives such as nanomaterials (nanofibrillated cellulose, nanosilica, nanoclay, expanded graphite), hemp & glass fibres, hemp shiv and polyvinyl acetate (PVAc) are determined. Samples were cured for 26 days in air at 20˚C / 60% RH after casting before being oven dried for a further two days at 50˚C (28 days total). Results show that the nanomaterials on their own had a mixed effect on the strength although nSiO2 as a solo additive performed exceptionally well. The combination of fibres in conjunction with PVAc also greatly enhanced the strength due to increased bond between the fibres and the matrix. In addition, Greenhouse Gas emissions (GHG, kgCO2eq) of an arbitrary block was determined for all composites and compared to the GHG of a commonly used lightweight aerated concrete block. Comparison of the normalised compressive strengths to the different loading conditions as outlined in BS EN 8103 shows that a more widespread use of pre-cast lime composites is possible and without unduly increasing GHG emissions.
The art of gathering: histories of international scientific conferences
Authors: Bigg Charlotte , Reinisch Jessica , Somsen Geert , Widmalm Sven 
Published: October 2023

AbstractHundreds of thousands of conferences have taken place since their first appearance in the late eighteenth century, yet the history of science has often treated them as stages for scientific practice, not as the play itself. Drawing on recent work in the history of science and of international relations, the introduction to this special issue suggests avenues for exploring the phenomenon of the international scientific conference, broadly construed, by highlighting the connected dimensions of communication, sociability and international relations. It lays out a typology of scientific conferences as a way of gaining an overview of their diversity in the nineteenth and twentieth centuries. It argues that the international scientific conference is a central locus for understanding science as a social, cultural and political practice.
Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial
Authors: Jo Jung Hyun , Kim Yong-Tae , Choi Ho Soon , Kim Ho Gak , Lee Hong Sik , Choi Young Woo , Kim Dong Uk , Lee Kwang Hyuck , Kim Eui Joo , Han Joung-Ho , Lee Seung Ok , Park Chang-Hwan , Choi Eun Kwang , Kim Jae Woo , Cho Jae Yong , Lee Woo Jin , Moon Hyungsik Roger , Park Mi-Suk , Kim Sangjae , Song Si Young 
Published: October 2023

Abstract
Background
The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict responses to GV1001. This Phase III trial assessed the efficacy of GV1001 with gemcitabine/capecitabine for eotaxin-high patients with untreated advanced PDAC.

Methods
Patients recruited from 16 hospitals received gemcitabine (1000 mg/m2, D 1, 8, and 15)/capecitabine (830 mg/m2 BID for 21 days) per month either with (GV1001 group) or without (control group) GV1001 (0.56 mg; D 1, 3, and 5, once on week 2–4, 6, then monthly thereafter) at random in a 1:1 ratio. The primary endpoint was overall survival (OS) and secondary end points included time to progression (TTP), objective response rate, and safety.

Results
Total 148 patients were randomly assigned to the GV1001 (n = 75) and control groups (n = 73). The GV1001 group showed improved median OS (11.3 vs. 7.5 months, P = 0.021) and TTP (7.3 vs. 4.5 months, P = 0.021) compared to the control group. Grade >3 adverse events were reported in 77.3% and 73.1% in the GV1001 and control groups (P = 0.562), respectively.

Conclusions
GV1001 plus gemcitabine/capecitabine improved OS and TTP compared to gemcitabine/capecitabine alone in eotaxin-high patients with advanced PDAC.

Clinical trial registration
NCT02854072.
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation
Authors: Pruenster Monika , Immler Roland , Roth Jonas , Kuchler Tim , Bromberger Thomas , Napoli Matteo , Nussbaumer Katrin , Rohwedder Ina , Wackerbarth Lou Martha , Piantoni Chiara , Hennis Konstantin , Fink Diana , Kallabis Sebastian , Schroll Tobias , Masgrau-Alsina Sergi , Budke Agnes , Liu Wang , Vestweber Dietmar , Wahl-Schott Christian , Roth Johannes , Meissner Felix , Moser Markus , Vogl Thomas , Hornung Veit , Broz Petr , Sperandio Markus 
Published: October 2023

AbstractS100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton’s tyrosine kinase-dependent tyrosine phosphorylation of NLRP3. Concomitant potassium efflux via the voltage-gated potassium channel KV1.3 mediates ASC oligomerization. This is followed by caspase 1 cleavage and downstream activation of pore-forming gasdermin D, enabling cytosolic release of S100A8/S100A9. Strikingly, E-selectin-mediated gasdermin D pore formation does not result in cell death but is a transient process involving activation of the ESCRT III membrane repair machinery. These data clarify molecular mechanisms of controlled S100A8/S100A9 release from neutrophils and identify the NLRP3/gasdermin D axis as a rapid and reversible activation system in neutrophils during inflammation.
Comprehensive pan‑cancer analysis of potassium voltage-gated channel Q4 (KCNQ4) gene across multiple human malignant tumors
Authors: Zhao Qing , Li Meizeng , Zhang Yunxiang 
Published: October 2023

AbstractA large number of studies indicate that Potassium Voltage-Gated Channel Q4 (KCNQ4) gene is the cause of non-syndromic hearing loss, but there are few studies investigating the role of KCNQ4 in cancers and scarcity of comprehensive analysis of its involvement in the diagnosis, methylation, mutation, prognosis of various cancer types. Therefore, the aim of this study is to examine the anticancerous and immune effects of KCNQ4 in various cancers and its potential value in breast cancer. In this study, we explored the potential role of KCNQ4 in cancers using public databases and the R software for bioinformatics analysis. The results showed that the low expression of KCNQ4 across specific cancer types was positively associated with low mutation frequency and methylation, and the improved survival. Eight small molecule compounds were identified that could potentially target KCNQ4. In addition, immunohistochemistry confirmed that the KCNQ4 expression was low in breast cancer. In vitro experiments confirmed that overexpression of KCNQ4 inhibited cell migration and invasion and promoted apoptosis. In summary, our comprehensive pan-cancer analysis highlights the potential of KCNQ4 as a cancer marker, and can be used as an auxiliary prognostic indicator and an indicator for immunotherapy in certain tumor types.
Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes
Authors: Fischer Katrin , Bradlerova Michaela , Decker Thomas , Supper Verena 
Published: October 2023

AbstractIntracellular bacteria produce antigens, which serve as potent activators of γδ T cells. Phosphoantigens are presented via a complex of butyrophilins (BTN) to signal infection to human Vγ9+Vδ2+ T cells. Here, we established an in vitro system allowing for studies of Vγ9+Vδ2+ T cell activity in coculture with epithelial cells infected with the intracellular bacterial pathogen Listeria monocytogenes. We report that the Vγ9+Vδ2+ T cells efficiently control L. monocytogenes growth in such cultures. This effector function requires the expression of members of the BTN3A family on epithelial cells. Specifically, we observed a BTN3A1-independent BTN3A3 activity to present antigen to Vγ9+Vδ2+ T cells. Since BTN3A1 is the only BTN3A associated with phosphoantigen presentation, our study suggests that BTN3A3 may present different classes of antigens to mediate Vγ9+Vδ2+ T cell effector function against L. monocytogenes-infected epithelia.
Dicationic ionic liquids (DILs) as rapid esterification catalyst of butyric fatty acid
Authors: El-Nagar Raghda. A. 
Published: October 2023

AbstractIn the presented work, a series of asymmetric dicationic ionic liquids (ADILs) with different alkyl chain length spacer between the two cation nuclei (imidazolium and pyridinium) with chlorine halide anion was designed, synthesized with excellent yield (89, 90 and 88%) and well characterized via different tools of analysis (FT-IR and 1H-NMR spectroscopy and thermal gravimetric analysis; TGA). The synthesized ADILs were examined for potential esterification as recyclable catalysts including the activity of catalytic performance, the reaction conditions justifying. The noted resulted data indicated that the butyric acid was converted perfectly into ester in presence of ADILs with short time of reaction. By completing our studies through the effect of chemical structures, concentrations, time and temperatures, we found that the synthesized Py-6-Imi exhibit the best catalytic performance with 96% as conversion value after 20 min at the ambient temperature (25 °C). The synthesized ADILs also recovered and reused for minimum three rounds without any significant reduction in the catalytic performance. Totally, the usage of ADILs in the esterification process offers lots of benefits such as perfect yield, quick time and environmentally friendly characteristics which make them the optimum sustainable compounds to be achieved in variety of industrial applications.
Role of fibular autograft in ankle arthrodesis fixed using cannulated screws: a proportional meta-analysis and systematic review
Authors: Bernasconi Alessio , Izzo Antonio , D’Agostino Martina , Mariconda Massimo , Coviello Antonio 
Published: October 2023

AbstractAnkle arthrodesis is commonly performed to treat end-stage ankle osteoarthritis. The aim of this study was to determine whether the use of fibular autograft might increase the fusion rate and decrease the complication rate in ankle arthrodesis (AA) fixed using cannulated screws. To perform this PRISMA-compliant proportional meta-analysis, multiple databases were searched for studies in which patients undergone AA (using exclusively cannulated screws and augmented with fibular bone graft) were followed. The characteristics of the cohort, the study design, surgical details, the nonunion and complication rate at the longest follow-up were extracted and recorded. The modified Coleman Methodology Score (mCMS) was applied to appraise the quality of studies. Two groups were built: arthrodeses fixed with screws combined with cancellous autograft (G1) and arthrodeses fixed with screws combined with cancellous autograft and augmented with a lateral fibular onlay (G2). A third group (arthrodeses fixed with screws and no graft, G3) was extracted from previous literature for a further comparison. Overall, we included 306 ankles (296 patients) from ten series (ten studies). In G1 and G2 there were 118 ankles (111 patients) and 188 ankles (185 patients), respectively. In patients where cancellous autograft was used, a further augmentation with a fibular lateral strut autograft did not change significantly the nonunion (4% [95% CI 1–9] in G1 vs. 2% [95% CI 0–5) in G2, p = 0.99) nor the complication rate (18% [95% CI 0–36] in G1 vs. 13% [95% CI 6–21) in G2, p = 0.71). Upon comparison with 667 ankles (659 patients, G3) in which arthrodeses had been performed without grafting, the nonunion and complication rates did not differ significantly either (pooled estimates: 3% [95% CI 1–3) in G1 + G2 vs. 3% [95% CI 2–4] in G3, p = 0.73 for nonunion; 15% [8–23] in G1 + G2 vs. 13% [95% CI 9–17] in G3, p = 0.93 for complications). In ankle arthrodesis fixed with cannulated screws combined with cancellous autograft at the fusion site, a construct augmentation with a distal fibular onlay strut graft positioned laterally at the ankle joint does not reduce the risk of nonunion or complication. In general, the use of bone graft does not influence significantly the nonunion nor the complication rate as compared to non-grafted screw-fixed ankle arthrodeses.Kindly check and confirm the corresponding author mail id is correctly identified.It's all correct
Assessment of the ground vibration during blasting in mining projects using different computational approaches
Authors: Hosseini Shahab , Khatti Jitendra , Taiwo Blessing Olamide , Fissha Yewuhalashet , Grover Kamaldeep Singh , Ikeda Hajime , Pushkarna Mukesh , Berhanu Milkias , Ali Mujahid 
Published: October 2023

AbstractThe investigation compares the conventional, advanced machine, deep, and hybrid learning models to introduce an optimum computational model to assess the ground vibrations during blasting in mining projects. The long short-term memory (LSTM), artificial neural network (ANN), least square support vector machine (LSSVM), ensemble tree (ET), decision tree (DT), Gaussian process regression (GPR), support vector machine (SVM), and multilinear regression (MLR) models are employed using 162 data points. For the first time, the blackhole-optimized LSTM model has been used to predict the ground vibrations during blasting. Fifteen performance metrics have been implemented to measure the prediction capabilities of computational models. The study concludes that the blackhole optimized-LSTM model PPV11 is highly capable of predicting ground vibration. Model PPV11 has assessed ground vibrations with RMSE = 0.0181 mm/s, MAE = 0.0067 mm/s, R = 0.9951, a20 = 96.88, IOA = 0.9719, IOS = 0.0356 in testing. Furthermore, this study reveals that the prediction accuracy of hybrid models is less affected by multicollinearity because of the optimization algorithm. The external cross-validation and literature validation confirm the prediction capabilities of model PPV11. The ANOVA and Z tests reject the null hypothesis for actual ground vibration, and the Anderson–Darling test rejects the null hypothesis for predicted ground vibration. This study also concludes that the GPR and LSSVM models overfit because of moderate to problematic multicollinearity in assessing ground vibration during blasting.