bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of B-to-B trade network models of structural evolution and monetary flows reproducing all major empirical laws
Authors: Ozaki Jun'ichi , Viegas Eduardo , Takayasu Hideki , Takayasu Misako 
Published: October 2023

Abstract
We develop a single two-layered model framework that captures and replicates both the statistical properties of the network as well as those of the intrinsic quantities of the agents. Our model framework consistently unifies two distinct yet interconnected elements that were previously only studied in isolation, namely methods related to temporal network structures and those associated with money transport flows. In this manner, we can explain how the micro-level dynamics of the agents within the network lead to the exogenous manifestation of the aggregated system statistical data en-wrapping the very same agents within the system. This is done by capturing the essential dynamics of collective motion in complex networks that enable the simultaneous emergence of tent-shaped distributions in growth rates within the agents, together with the emergence of scaling properties within the network in the study. We can validate the model framework and dynamics by applying these to the context of the real-world inter-firm trading network of firms in Japan and comparing the results of the statistical distributions at both network and agent levels in a temporal manner. In particular, we compare our results to the fundamental quantities supporting the seven empirical laws observed in data: the degree distribution, the mean degree growth rate over time, the age distribution of the firms, the preferential attachment, the sales distribution in steady states, their growth rates, their scaling relations generated by the model. We find these results to be nearly identical to the real-world data. The framework has the potential to be transformed into a forecasting tool to support decision-makers on financial and prudential policies.
Effect of liver transplantation with retrograde reperfusion on early postoperative recovery of liver function and its risk factors
Authors: Shen Jiajia , Wang Ming , Yang Chengkai , Cai Qiucheng , Jiang Yi 
Published: October 2023

Abstract
Background
The purpose of this study was to investigate effect of liver transplantation with retrograde reperfusion on early postoperative recovery of liver function and its risk factors.
Methods
The clinical data of 136 patients who underwent liver transplantation at the 900th Hospital of the Chinese People's Liberation Army Joint Support Army from January 2015 to January 2021 were retrospectively analyzed. There were 115 males and 21 females; the age of these patients ranged from 20 to 70 years, with a median age of 51 years. All patients signed an informed consent, in accordance with medical ethics regulations. The patients were divided into retrograde reperfusion (RTR) group (n=108) and initial portal reperfusion (IPR) group (n=28) according to different liver perfusion methods during transplantation. After the two groups were matched by propensity score of 1:1, 23 patients in the two groups were compared in the recovery of liver function after operation.Within the cohort of 114 patients under scrutiny, rigorous exclusions were applied to the RTR group. Specifically, 8 cases presenting initial hepatic artery unveiling after retrograde reperfusion, and 14 cases with simultaneous hepatic artery and portal vein unveiling post RTR, were omitted. Consequently, the study's focal analysis encompassed 86 cases in the RTR subset and 28 cases within the IPR subset.
The patients in RTR group (n=86) were further divided into EAD group (n=19) and non-EAD group (n=67) according to whether early hepatic allograft dysfunction (EAD) occurred after operation. The effects of preoperative and intraoperative parameters and liver perfusion methods on EAD after liver transplantation were analyzed.
Results
Alanine aminotransferase (ALT) was 329 (211~548) and 176 (98~282) U/L on the 3rd and 7th day after RTR, respectively, which was significantly lower than 451 (288~918) and 251 (147~430) U/L in the IPR group (Z =-1.979, -2.299, P= 0.048, 0.021). Aspartate aminotransferase (AST) on postoperative days 3, 5, and 7 was 252 (193, 522), 105 (79, 163), and 93 (41, 135) U/L in the RTR group, respectively; it was also significantly lower than 328 (251, 724), 179 (129, 306), and 150 (91, 200)U/L in the IPR group (Z=-2.212, -3.221, -2.979; P=0.027, 0.001, 0.003). Logistic regression analysis showed that MELD score was an independent risk factor for EAD after liver transplantation.
Conclusion
RTR liver transplantation is more favorable for patients' early postoperative liver function recovery. For patients undergoing liver transplantation for RTR, preoperative MELD score was an independent risk factor for their postoperative development of EAD.
A Case Report of a Long-Surviving Elderly Patient with Lung Squamous Cell Carcinoma and Oncogenic Driver Alterations
Authors: Xun Pei , Zong Jiabao , Lu Yanli , Niu Xueliang , Song Chunqing 
Published: October 2023

Abstract
Background: MET (mesenchymal-epithelial transition) and Epidermal growth factor receptor (EGFR) mutations have a low incidence in lung squamous cell carcinoma (LUSC). For patients with MET/EGFR TKI (Tyrosine Kinase Inhibitor)-resistant driver gene mutation-related non-small cell lung cancer, selection of an appropriate treatment strategy is more difficult.
Case presentation: This paper describes a patient who was diagnosed with local advanced LUSC (stage cT2N3M0), harboring MET and EGFR mutations. This patient received toripalimab in combination with chemotherapy and achieved a partial response, with long-term progression-free survival of more than 36 months. During the treatment, no adverse events occurred.
Conclusions: Immune checkpoint inhibitors may be considered as a later-line treatment option for patients with MET-mutated advanced LUSC.
Teaching Breaking Bad News in a gyneco-oncological setting: a feasibility study implementing the SPIKES framework for undergraduate medical students
Authors: Zemlin Cosima , Nourkami-Tutdibi Nasenien , Schwarz Pascal , Goedicke-Fritz Sybelle 
Published: October 2023

Abstract
BACKGROUND
Delivering life threatening information to patients described as “breaking bad news (BBN)” is a central task for physicians. Many aspects influence these conversations on both sides, patients, and doctors. BBN affects the patient-physician relationship, patients’ outcome, and physicians’ health. Many physicians are still untrained for this multi-facetted task and feel unprepared and overburdened when facing situations of BBN. Therefore, any faculties should aim to integrate communication skills into their medical curricula as early as possible. The SPIKES model is an effective framework to deliver BBN. We evaluated the feasibility and obstacles of a BBN seminar and its acceptance and learning curve among undergraduate medical students.
METHODS
158 2nd year undergraduate medical students attended a compulsory BBN seminar. The task was to deliver a cancer diagnosis to the patient in a patient - physician role-play in a gyneco-oncological setting before and after a presentation of the SPIKES model by the lecturer. The students evaluated important communication skills during these role-plays respectively. Self-assessment questionnaires were obtained at the beginning and end of the seminar.
RESULTS
Most students indicated that their confidence in BBN improved after the seminar (p=<0.001). They like the topic BBN to be part of lectures (76%) and electives (90%). Communication skills improved. Lecturer and seminar were positively evaluated (4.57/5).
CONCLUSION
The seminar significantly increased confidence and self-awareness in delivering life-threatening news to patients among undergraduate students. Important learning aspects of BBN and communication skills could be delivered successfully to the participants within a short time at low costs. The integration of communication skills should be implemented longitudinally into medical curricula starting before clinical education to increase the awareness of the importance of communication skills, to decrease anxiety, stress, and workload for future doctors and – most importantly – to the benefit of our patients.
Accidental traffickers: Qualitative findings on labour recruitment in Ethiopia
Authors: Busza Joanna , Shewamene Zewdneh , Zimmerman Cathy , Erulkar Annabel , Hailu Eyasu , Negeri Lemi , Anderson Elizabeth , Lo Yuki 
Published: October 2023

Abstract
Background
The growth of labour migration and associated risks of human trafficking and exploitation remain significant global human rights and health challenges. There is increasing policy interest in addressing structural determinants of adverse migration outcomes such as migrants’ use of informal employment recruiters. In Ethiopia, “safe migration” policies have introduced regulations for registered private employment agencies and penalties for anyone else placing migrants into work overseas. Yet migrants continue to use informal facilitators who are often demonised as traffickers without evidence of their motivations, experiences or perceptions. We conducted qualitative interviews with 28 informal facilitators as part of a study into how recruitment practices shape risks for female migrants seeking domestic work in the Middle East and Gulf States. We present the realities of irregular recruitment on the ground, and how these practices are affected by policies that dichotomise recruiters into legal/safe and illegal/unsafe categories.
Results
We identified four main themes. First, arranging migration from rural areas differs from in the capital, Addis Ababa, where laws and regulations originate. Outside Addis Ababa, registration was difficult for facilitators to arrange, with little incentive to do so due to its lack of importance to prospective migrants. Second, the ability to circumvent legal requirements was considered an advantage of informal facilitators because it reduced costs and expedited migrants’ departure. Third, facilitators did not work alone but operated in long “chains” of diverse actors. This meant migrants’ safety was not determined by any given individual, but spread across numerous people involved in sending a migrant abroad, some of whom might be registered and others not. And finally, facilitators did not believe they could realistically safeguard migrants once they were outside of Ethiopia and working under different laws and employers.
Conclusions
Findings from this study add to a growing body of work demonstrating the diversity of people involved in the migration process, and consequent oversimplification of popular policy solutions. A more effective approach might be to constructively engage informal facilitators and identify ways they could assist with referring migrant workers to registered agencies and safe employment, rather than criminalising their participation.
ZQL-4c exerts antitumor effects by specifically targeting SCD1 in triple-negative breast cancer both in vitro and in vivo
Authors: Li Xiaorui , Cao Hui , Sun Hongna , Wang Shuya , Guo Xiangyu , Wang Shisheng , Sun Tao 
Published: October 2023

Abstract
Breast cancer represents the most prevalent tumor among women and serves as a primary cause of cancer-associated mortality in China. Oleanolic acid, a pentacyclic triterpenoid isolated from various natural plants, has demonstrated a wide range of biological properties including anti-inflammatory, anti-viral, anti-cancer, etc. Our previous research indicated that ZQL-4c, an oleanolic acid derivative, can inhibit the proliferation of breast cancer cells, particularly those of triple-negative breast cancer. This study aims to delve deeper into the potential inhibitory mechanisms of ZQL-4c on triple-negative breast cancer. Our results illustrated that ZQL-4c suppressed the proliferation of MDA-MB-231 and MDA-MB-468 cells in both a dose- and time- dependent manner. Furthermore, ZQL-4c induced apoptosis and G2/M cell cycle arrest. Using transcriptomics and rescue experiments, our findings suggest SCD1 as a potential target of ZQL-4c. In vivo, ZQL-4c treatment noticeably curbed tumor growth in a mouse breast cancer xenograft model. In summary, ZQL-4c displays potent antitumor benefits both in vitro and in vivo, making it a potential therapeutic agent for triple-negative breast.
Slime mold algorithm for topology optimization: metagratings inverse design.
Authors: EDEE Kofi , Granet Gérard , Bonnet Pierre 
Published: October 2023

Abstract
In this paper we discuss the use of a metaheuristic (MH) gradient-free optimization method, specifically the slime mold algorithm (SMA), combined with the topology optimization (TO) method for metasurfaces using spectral modal methods. The motivation behind using a MH approach comes from the drawbacks associated with traditional gradient-based techniques.Normally, Gradient-based methods require the calculation of the electromagnetic (EM) field at certain nodes within the computation domain. However, in spectral modal methods, this is unnecessary since these methods can compute the EM response without the need for field component values. Second, optimizing metagratings often involves a multimodal objective function with multiple local minimums and Gradient-based methods might struggle with finding the global optimum.So to overcome these drawbacks, we propose using a MH approach, specifically the slime mold algorithm (SMA). We apply SMA to a metasurface design, especially in the context of TO and spectral methods, which is relatively unexplored. By coupling both TO with SMA, we successfully design metagratings capable of deflecting incident waves into a desired transmission angle.
Influence of Intraocular Pressure Status on the Formation of Functional Filtering Blebs after Trabeculectomy on Rhesus Monkey eyes
Authors: Tu Shu , Hu Dongpeng , Yang Runcai , Xu Xiaoyu , Luo Ziming , Ge Jian 
Published: October 2023

Abstract
Purpose: To improve the maintenance and management of filtering blebs after glaucoma filtering surgeries (GFS), it is essential to understand the effect of intraocular pressure on the formation of function blebs.
Here, we utilized a monkey model of chronic ocular hypertension (COHT) to reveal the relationship between pre-operative high-IOP and postoperative bleb fibrosis.
Methods: First, four eyes after high IOP induction and four with normal IOPs from eight monkeys received trabeculectomies. Subsequently, IOPs and volume of blebs were measured by Tonopen and anterior segment optical coherence tomography in different time points over 28 days after surgery. Then, histopathology and immunohistochemistry were performed to reveal myofibroblast cells and collagen deposition of filtering blebs.
Results: In the early stage after surgeries, IOPs were significantly reduced in the COHT eyes compared to the control eyes. However, IOPs of the COHT eyes gradually increased to 16.75±4.99 mmHg, which was in the normal range but overall higher at the end of the 28-day observation. Consistently, denser fibrosis and scar tissue deposition were observed in the COHT group.
Conclusions: Taken together, these results indicated that pre-operative high IOP status might promote bleb fibrosis, compromising the outcome of filtering surgeries. Furthermore, this finding suggested that pre-operative high IOP could induce confounding or effect modification, and more attention should be paid to the following anti-scarring research. From the perspective of translational medicine, controlling IOP before clinical operation is very important to improve the surgical effect.
Superior induced pluripotent stem cell generation through phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming
Authors: Chowdhury Mohammad Mahfuz , Zimmerman Samuel , Leeson Hannah , Nefzger Christian Maximilian , Mar Jessica Cara , Laslett Andrew , Polo Jose Maria , Wolvetang Ernst , Cooper-White Justin John 
Published: October 2023

Abstract
Background:Human cell reprogramming traditionally involves time-intensive, multi-stage, costly tissue culture polystyrene (TCPS)-based cell culture practices that ultimately produce low numbers of reprogrammed cells of variable quality. Previous studies have shown that very soft two-and three-dimensional hydrogel substrates/matrices (of stiffnesses </= 1 kPa) can drive ~2X improvements in human cell reprogramming outcomes. Unfortunately, these similarly complex multi-stage protocols lack intrinsic scalability, and furthermore, the associated underlying molecular mechanisms remain to be fully elucidated, limiting the potential to further maximise reprogramming outcomes.
Methods:Polyacrylamide hydrogels of varying stiffness (1 kPa – 1.3 MPa) were surface activated with either Sulfo-SAMPAH or poly-L-dopamine and thereafter gelatin functionalised. Mouse and human fibroblast cells were reprogrammed on these substrates using endogenous (mouse) or exogenous (human) transcription factors for 18 days. Cells were phenotyped during the each of the reprogramming phases. RNA sequencing and bioinformatic analysis elucidated critical molecular drivers of reprogramming upon exposure to the hydrogels, confirmed through gene knockdown experiments.
Results:In screening the largest range of polyacrylamide hydrogels of varying stiffness to date, we found that a medium stiffness gel (~100 kPa) significantly increased the overall number of reprogrammed cells by up to ten-fold (10X), accelerated reprogramming kinetics, improved both early and late phases of reprogramming, and produced iPSCs having more naïve characteristics and lower remnant transgene expression, compared to the gold standard tissue culture polystyrene practice. Functionalisation of these pAAm hydrogels with poly-L-dopamine (PDA) enabled, for the first-time, continuous, single-step reprogramming of fibroblasts to iPSCs on hydrogel substrates (noting that even the TCPS practice is a two-stage process). Comparative RNA-Seq analyses coupled with experimental validation revealed that a novel reprogramming regulator, Phactr3, upregulated in the gel condition at a very early time-point, was responsible for the observed enhanced reprogramming outcomes.
Conclusions:This study provides a novel culture protocol and substrate for continuous hydrogel-based cell reprogramming and previously unattained clarity of the underlying mechanisms via which substrate stiffness modulates reprogramming kinetics and iPSC quality outcomes, opening new avenues for producing higher numbers of quality iPSCs or other reprogrammed cells at shorter timescales.
Rock Fluid Interactions During Seawater Injection in Carbonates: an Experimental Evaluation on Dolomitization and Anhydrite Precipitation
Authors: Novaes Aline Machado de Azevedo , Faria Rafaella Magliano Balbi , Silva Mônica Antunes Pereira da , Peçanha Ricardo Pires 
Published: October 2023

Abstract
Carbonates are expected to be reactive during the injection of fluids as a secondary recovery method in an oilfield reservoir. Desulphated seawater is usually chosen to reduce scaling potential for barium and strontium sulfates at the producer wells. However, desulfation presents some operational difficulties, often limiting the platform injection’s capacity. The chemical interactions between seawater and carbonate reservoirs affect produced water composition and must be considered for scaling predictions. Reactive transport models had shown that dolomitization increases anhydrite precipitation, reducing sulphate concentration in the produced water. This paper studied the reaction between calcite and three different fluids: seawater, seawater without sulphate and seawater without magnesium. All tests were performed in the presence of CO2 and using a semi-batch reactor. The focus was to analyze the effects of possible dolomitization on sulfate concentration in reservoir conditions. As the scale potential is strongly related to the sulphate concentration, the previous knowledge of this behaviour plays a key role at the water quality decision. Experimental results confirmed simulation predictions.
The associations between sleep quality, mood, pain and appetite in community dwelling older adults: a daily experience study
Authors: Wijnhoven Hanneke , Kok Almar A.L. , Schaap Laura A , Hoekstra Trynke , Stralen Maartje M van , Twisk Jos W.R. , Visser Marjolein 
Published: October 2023

Abstract
OBJECTIVES: To investigate the daily life experiences of sleep, mood, and pain in relation to appetite in community-dwelling older adults aged 75 years and older, stratified by sex.
DESIGN: Existing data from a daily experience study embedded in the Longitudinal Aging Study Amsterdam (LASA) among the oldest-old (≥75 years)
SETTING: LASA is an ongoing cohort study of a nationally representative sample of older adults aged ≥55 years from three culturally distinct regions in the Netherlands
PARTICIPANTS: 434 community-dwelling older adults aged ≥75 years
MEASUREMENTS: Participants filled-out a one-week diary on daily experience of pain, mood, last night sleep (10-point Likert scale), and appetite (5-point Likert scale) on five measurement occasions between 2016-2021. (Hybrid) linear mixed models were used to investigate overall, within-subject and between-subject association between mood, sleep, and pain (independent variables) and appetite (dependent variable), while correcting between-subject associations for season, age, educational level, partner status, body mass index, alcohol consumption, physical activity level, smoking status, chronic diseases and use of nervous system medication, stratified by sex.
RESULTS: Averaged over all days, males reported a poor appetite on 12% of the days and females on 19% of the days. Statistically significant between-subject associations with a poorer appetite were found for lower mood (unstandardized b = 0.084 [95% CI 0.043–0.126] (males), (b = 0.126 [95% CI 0.082–0.170] (females)), poorer sleep (b = 0.045 [95% CI 0.072–0.083] (males), (b = 0.51 [95% CI 0.017–0.085] (females)) and more severe pain in males only (b = 0.026 [95% CI 0.002–0.051]). Except for pain, within-subject associations were somewhat weaker: mood: b = 0.038 [95% CI 0.016–0.060] (males), (b = 0.082 [95% CI 0.061–0.104] (females)); sleep: b = 0.029 [95% CI 0.008–0.050] (males), (b = 0.15 [95% CI 0.005–0.025] (females)); and pain (b = 0.032 [95% CI 0.004–0.059] (males)).
CONCLUSIONS: This study found that poor sleep, low mood (more strongly in females) and more severe pain (males only) are associated with poor appetite in older adults on a daily level both within and between persons. Sex differences in factors related to poor appetite should be considered in future research.