bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroalcoholic extract ofScrophularia striatahas a significant therapeutic effect on thioacetamide-induced liver cirrhosis in rats
Authors: Amri Jamal , Jamalian Mohammad , Salami Zahre , Akbari Ahmad , Alaee Mona , Soleiman Fatemeh Azizi , Alimoradian Abbas 
Published: December 2023

AbstractObjectivesLiver cirrhosis is one of the most important causes of death from liver diseases. Nowadays, the use of herbal medicines has increased due to its availability, less side effects and cheapness for the treatment of liver diseases. The present study was conducted to examine therapeutic effects of hydroalcoholic extract ofScrophularia striata(S. striata) on thioacetamide-induced liver cirrhosis in rats through evaluate its effects on oxidative stress markers and the expression of metalloproteinase 1 (TIMP 1), toll-like receptor-4 (TLR-4), and Mitofusin (MFN2) genes.Methods24 male rats were selected by simple random sampling. Rats were randomly assigned to four groups: group I: healthy rats, group II: thioacetamide (TAA) injected rats, group III: TAA injected rats+100 mg/kg bw ofS. striataand group IV: TAA injected rats+200 mg/kg bw ofS. striata. Liver cirrhosis was induced in rats by a 300 mg/kg bw TAA administration twice with an interval of 24 h. After 8 weeks of treatment byS. striataat doses of 100 and 200 mg/kg bw, biochemical factors and oxidative stress markers (SOD, TAC, GPX, CAT and MDA) were measured using spectrophotometric methods. Also, gene expression of TIMP 1, TLR-4, and MFN2 were analyzed using real-time PCR. ANOVA and Bonferroni post hoc test analysis were applied to evaluate the data.ResultsThe results showed theS. striataextract significantly improve the serum ALT, AST and ALP levels, TIMP 1, TLR-4, and MFN2 genes and oxidative stress markers (SOD, TAC, GPX, CAT and MDA) in the liver tissues when compared to control group (p<0.05). Also, it was found that the beneficial effects of theS. striatawere dose-dependent.ConclusionsBased on the results obtainedS. striataby reducing the expression of TIMP 1, TLR-4, and MFN2 genes and improving oxidative stress might be used as adjuvant treatment for liver cirrhosis.
Multi-layer co-extrusion blow molding
Authors: Steinmetz Erik , Scanlon Seamus , Schneider Tyler , Maia João 
Published: December 2023

Abstract
Multi-layer co-extrusion via the layer multiplication technique and a blow-molding set-up were used to produce bottles with a 129-layered structure of a model system of alternating polystyrene (PS) and poly (methyl methacrylate) (PMMA) layers. This method shows layer retention and thickness control with the use of melt rotation during the extrusion process. Samples were extruded and deformed angularly at different rotation speeds, blow-molded into bottles, and the overall wall thickness and analysis of individual layer thicknesses were performed. Angular rotation leads to weld line deformation and a change in layer thickness above a critical rotation speed in which the weld lines, inherited in the extrusion of the tube structures, are suitably deformed helically leading to uniform deformation during the blowing process. This method has potentially large implications for single cavity blow molding processes where high-performance properties, e.g., high barrier, insulation, mechanical, are of upmost importance, potential industries include gas transport, specialty packaging, and medical.
The multi-layer secure communication system based on 2D-OCDMA coding
Authors: Kong Lingchao , Liu Kan , Yu Qiulei , Hou Fenfei 
Published: December 2023

Abstract
This paper presents a novel multi-layer secure communication system that bases 2D-OCDMA technology to enhance the security and number of users of the system. The system innovatively combines RSA encryption, polarization multiplexing, and address coding techniques to protect and transmit the data. At the transmitting end, the data is encrypted by algorithm and then encoded by address code. The encoded optical data is split into two orthogonal polarization states and sent over the same channel. At the receiving end, only the optical signals in the matching polarization state can be retrieved by the polarizer with the right angle. The retrieved data is then decoded by the address code and decrypted by the algorithm to recover the original data. This system achieves multi-layer security and capacity enhancement by processing the information at different layers. The feasibility of the system is demonstrated by joint experimental simulation using Java programming language and Optisystem simulation software. In this paper, low BER transmission of 4 code words for 8 users 50 km 1Gbit/s is realized using optical orthogonal codes (OOC) with BER around 10−30. It realizes the enhancement of 4-user to 8-user without affecting the transmission effect.
In vitro and in silico study for plant growth promotion potential of indigenous Ochrobactrum ciceri and Bacillus australimaris
Authors: Dilshad Rimsha , Mazhar Sumaira , Munir Sajida , Jamil Nazia , Batool Rida 
Published: December 2023

Abstract
Insights into plant and bacterial associations, along with their genome mining, have paved the way for the improvement of the agriculture sector. Initially, 69 morphologically different bacterial strains were isolated from 6 different extreme environment samples. For in vitro screening of plant growth-promoting bacteria, auxin, hydrogen cyanide, and antibiotic production along with phosphate solubilization potential was estimated. Only 15 strains exhibited noteworthy production of plant growth-promoting compounds. Ochrobactrum ciceri CS-10 fostered Triticum aestivum and Zea mays seedling root growth remarkably (104.12 and 159%, respectively), while Bacillus australimaris TP-10 significantly increased the number of leaves in T. aestivum (166.66%) and Z. mays (133.33%) seedlings. These strains also boosted seedling biochemical traits, like indole acetic acid, peroxidase, and soluble protein content. Particularly, O. ciceri elevated peroxidase content greatly in T. aestivum (249.7%) and Z. mays (260.5%). Scanning electron micrographs of inoculated roots revealed the aggregation of cells at the roots of Z. mays, whereas single cells/micro-colonies were observed on T. aestivum roots. For in silico analysis, AntiSMASH was used for genome mining of the environmental Ochrobactrum sp. and B. australimaris reference genome. This genome mining unveiled diverse gene clusters encoding; terpenes, beta-lactones, acyl-amino-acids, aryl polyenes, lanthipeptide, and siderophores, etc. Two common biosynthetic gene clusters (terpenes and beta-lactones) were identified in these strains, which can act as plant growth promoters. This symbiotic plant–bacteria relationship has promising ecological and economic implications, offering avenues for beneficial applications.
Digital Cultural Heritage, Cybersecurity, and the Human Factor
Authors: Vuković Marin , Štefanac Tamara 
Published: December 2023

Abstract
Digital heritage, with its intellectual and cultural identity value, constitutes a significant asset. This also makes it an important asset in the cyber market. Cultural heritage institutions, recognising the vital role of digital assets, confront various information security risks and must adopt cyber threat related strategies to counter potential cyber-attacks. This paper first investigates the susceptibility of digital heritage objects to cyber threats by examining their distinctive characteristics. The study subsequently poses research enquiries concerning the cybersecurity proficiency and general awareness of cultural heritage professionals. A conducted survey in Croatia among these professionals analyses their information and computer practices related to the storage and preservation of digital cultural heritage. Findings reveal that while overall cybersecurity awareness is commendable, there exists a deficiency in cybersecurity and data protection training among cultural heritage professionals, even at the basic level. Additionally, the study highlights insufficient technical support and equipment for cybersecurity within cultural heritage institutions.
20 Años sobre el Impacto de la Investigación Educativa en la Práctica. Algunas Recomendaciones y Propuestas de Mejora
Authors: García Rodríguez Mª del Pilar , Coronel Llamas José Manuel , Gónzález-Falcón Inmaculada , Gómez-Hurtado Inmaculada 
Published: December 2023

En los últimos veinte años, la investigación sobre el impacto sobre la práctica educativa ha sido objeto de una atención creciente en el contexto internacional y se ha convertido en una preocupación de los profesionales, investigadores y responsables políticos. En este sentido, la literatura se ha ocupado de explorar cómo el impacto es actualmente teorizado e investigado. El objetivo de este trabajo ha sido derivar recomendaciones y propuestas de mejora para cerrar la brecha de larga duración existente entre la investigación y la práctica, a partir de la revisión de la literatura correspondiente al periodo 2000-2020 de los estudios sobre el impacto de la investigación educativa en la práctica. Se revisaron las bases de datos WOS, Scopus y ProQuest. Partimos de 237 artículos, seleccionamos 145 y realizamos un análisis de contenido identificando un total de 50 recomendaciones y propuestas, de carácter general, asociadas a los contenidos requeridos y, por último, aquellas vinculadas a consideraciones metodológicas. Los resultados del análisis realizado, reflejan el conocimiento disponible en torno al impacto de la investigación educativa en la práctica, los agentes principales implicados, las políticas a desarrollar en diversos ámbitos, las orientaciones metodológicas sugeridas, así como las implicaciones para la formación inicial y permanente del profesorado
Barriers to Adherence to Oral Hormonal Therapy Among Breast Cancer Women
Authors: Abozead Shalabia El-Sayed , William Neama Fosdok , Mahammad Zienab Abd-El-lateef , Khallaf Salah Mabrouk , Almageed Asmaa Sayed Abd 
Published: December 2023

BACKGROUND: Oral hormonal medication is an essential part of the management of breast cancer for hormone receptor-positive patients. OBJECTIVE: This study aimed to evaluate barriers to adherence to oral hormonal therapy among breast cancer women. METHOD: A descriptive study was utilized on 200 adult women diagnosed with metastatic breast cancer, newly received oral hormonal therapy. Those women were admitted to the outpatient clinic at South Egypt Cancer Institute at Assiut University. Using interview questionnaire sheet included, demographics, medical data, patient knowledge assessment, Morisky Medication adherence scale, and factors affecting drug adherence checklist. RESULTS: The highest percentage among the studied sample their age was above 4o years (91%). Around (50%) the duration of illness was more than 5 years. 57% of patients the duration of oral hormonal therapy was more the three years. Our study explores that studied patients nearly had no knowledge regarding all items of oral hormonal therapy. In addition, most of them are not compliant with oral hormonal therapy. The most important predictor factors for medication compliance are psychological/behavioral factors. CONCLUSION: Most of the patients are not compliant with oral hormonal therapy, so, nurses should counsel cancer patients about oral hormonal therapy, addressing reasons for no adherence and handling them.
To Compare The Two Approaches Of Nerve Flossing Technique On Pain, Lumbar Mobility And Straight Leg Raise In Subjects With Sciatica
Authors: Walia Carolina , Singh Vijayshree 
Published: December 2023

Background: Sciatica is one of the most common painful and disabling conditions. Nerve flossing technique commonly called as neural mobilization are the forms of manual therapy that are used in an effort to reduce radiating pain and improve range of motion. A wide range of physical therapy interventions have been proposed to be effective, however the efficacy of neural mobilization technique is still undetermined in developing countries like India. Purpose: A study to compare the two approaches of nerve flossing technique on pain, lumbar mobility and striaght leg raise in subjects with sciatica. Study design: Quasi- Experimental study, comparative in nature Methodology: A total of 45 subjects were selected for the study as per inclusion and exclusion criteria between age group of 20-55 years. Participants were divided into 3 groups of 15 subjects each. Group A (control), Group B (Experimental-1) and Group C (experimental-2). Group A was receive Transcutaneous Electrical Nerve Stimulation (TENS), Hydro-collateral pack, Group B was receive slider mobilization (Nerve Flossing Technique) and Group C was receive single joint mobilization on knee (Nerve Flossing Technique). The baseline data was recorded on 1th day (pre- intervention) and 5th day (post-intervention) and then on 10th day (post-intervention). Total 10 sessions per subject was given over 2 weeks i.e., 5 sessions per week. The collected Data was analyzed by using ANOVA and other statistical tests as appropriate Results: The result showed significant improvement in slider mobilization on pain, lumbar mobility and striaght leg raise in subjects with sciatica. Conclusion: The present study concludes that slider mobilization is most effective nerve flossing technique in improving pain, lumbar mobility and striaght leg raise in subjects with sciatica. Trial registration number (TRN): Not applicable.
La trajectoire d’Émile Guillaumin
Authors: Roche Agnès 
Published: December 2023

Émile Guillaumin (1873-1951) est, en France, le plus connu et le plus cité des écrivains paysans. Sa trajectoire est bel et bien exceptionnelle. Demeuré paysan sa vie durant, il tente de pénétrer un champ littéraire particulièrement fermé aux classes populaires. Pour cela, il met en œuvre une stratégie de brandissement de son stigmate social, stratégie temporairement payante, puisqu’il parvient à publier plusieurs recueils de poèmes et des romans. Mais cette stratégie rencontre vite des limites. Et après la Grande Guerre, il est contraint de se réorienter vers une activité journalistique. Il devient alors une sorte de chroniqueur spécialiste des campagnes, dans les années 1930.
Terre et Foi
Authors: Hertrampf Marina Ortrud 
Published: December 2023

La crise et la disparition du monde paysan traditionnel sont traitées de diverses manières dans la littérature française contemporaine. Contrairement aux œuvres du nouveau roman régional, les œuvres régionalistes écrites du point de vue des paysans, eux-mêmes touchés par les changements structurels sont peu connues, voire inconnues. Avec Joël Robin, l’article présente un paysan écrivain de l’Ouest qui met en relation le déclin de la culture paysanne avec la sécularisation croissante. Considérant son écriture comme un « testament paysan » documenté sur les vertus paysannes pour les citadins et les générations suivantes, ses textes ancrés dans le régionalisme sont à la fois une célébration des petits paysans français, une transfiguration nostalgique du « bon vieux temps » et une analyse culturelle pessimiste de la société, et aboutissent finalement à un plaidoyer pour une durabilité et une écologie motivées par le christianisme.
Unique accessories and connection network of a Gepid Period child burial. New data on the distribution of early medieval ivory artefacts
Authors: Tóth Ágnes B. , Wilhelm Gábor , Tóth Zsuzsanna 
Published: December 2023

AbstractThe Gepid Period row cemetery at Tiszaug-Országúti bevágás was unearthed in 2018–2019. Grave 301 was one of the outstanding burials amongst the 194 graves unearthed thus far. It kept the remains of a 9–11-year old boy, who was laid to rest in a scale-down burial created according to the funerary customs of the area and era but dressed in a mortuary costume and provided with goods befitting adult men. He had a purse hanging from his belt, containing an iron knife, and some pieces of flint. A double-row antler comb was placed beside his head. A cast copper alloy belt buckle with a shield-shaped pin base and punch-mark decoration fastened his clothing on the front. While buckles of this type were widely used at that time, the closest analogies to the punch-mark decoration could be collected from the Carpathian Basin. Based on those, the burial could be dated to the mid or late 6th century AD. Another outstanding feature of the cemetery was the four burials (including Grave 301) where the deceased were laid to rest in coffins made from or imitating log boats.Grave 301 also contained a rounded conical ivory object. The optical microscope and vibration spectroscopy analyses confirmed the initial hypotheses of the finders about the raw material of the artefact. Despite carrying out a comprehensive survey for analogies and an analysis of production and use-related marks, we could not determine what the object could have been used for; it may be a semi-finished product, but it could also be a toy or amulet. At any rate, it was made from a raw material which was extremely rare in the eastern part of the Carpathian Basin in the period in question. Grave 301 was positioned in a cluster comprising more child burials, with the graves of two adult women at the fringes; the ongoing archaeogenetical investigations may shed light on the connections between them.
Simulación biomédica para la educación
Authors: González Vargas Andrés Mauricio , Castro Benavides David Alejandro 
Published: December 2023

La bioinstrumentación es una de las líneas fundamentales de la ingeniería biomédica, y se enfoca en conocer los fundamentos necesarios para comprender el funcionamiento de los equipos biomédicos. Por esta razón, el aprendizaje a través de la práctica es de gran importancia, pues permite contextualizar adecuadamente los conocimientos adquiridos.
En su gran mayoría, estas experiencias son desarrolladas de manera presencial, pero muchas de ellas pueden ser trasladadas a ambientes online en que simuladores tanto de la actividad biológica como de los equipos que la miden permitan al estudiante practicar el uso de estos dispositivos y conocer sus principios de diseño.
En este capítulo presentaremos dos plataformas web: UAOSIMS y V-ESU, que sirven como laboratorio para el aprendizaje online de temas clave en el área de bioinstrumentación, y en donde los estudiantes pueden encontrar un conjunto de herramientas informáticas que brindan la posibilidad de efectuar simulaciones computacionales de varias señales fisiológicas e interactuar con módulos simulados que cumplan con las funciones fundamentales de diversos equipos biomédicos. Además, permite llevar a cabo actividades de entrenamiento en el manejo de estos equipos a través de videos educativos.
Experiencias de investigación inspiradoras
Authors: Daza-Orozco Carlos Eduardo , Norman-Acevedo Eduardo , Cera-Ochoa Raúl Antonio , Acosta-Triviño Ricardo 
Published: December 2023

Iniciación Científica colabora de forma permanente con instituciones de educación superior - IES, organismos públicos y privados; y, agentes sociales, en la formación, desarrollo y divulgación de la investigación para lograr una asertiva incidencia en la sociedad.
Dentro de las actividades permanentes como red (transe- inter) institucional, es la organización de escenarios para la presentación de resultados científicos en las diversas áreas del conocimiento. En este propósito se inscribe la colaboración con veintiocho (28) IES Colombianas en la estrategia de apropiación social del conocimiento bautizada: XPOILERS: Festival de Stand up científicos e investigativos.
Xpoilers desde la conformación de su nombre, realizó varias apuestas para la comunicación de la ciencia a partir de varios componentes como lo fueron:
XP: “Experiencias”
Poiler: “Diversión”
Expo: “Exposiciones”
Espóiler: “Adaptaciones documentadas”; y también en su acepción en jerga de redes sociales, “anticipar o revelar detalles”
Y, que basadas en el formato de monólogos y puestas en escena, nos presentó un matiz interesante para ir más allá de la clásica organización de una feria de proyectos para convertirse en un espacio colectivo de encuentro con la investigación.
DESARROLLANDO LA COMPETENCIA DE LA INNOVACIÓN EN JÓVENES UNIVERSITARIOS USANDO JUEGOS SERIOS DIGITALES PARA EL DESCUBRIMIENTO DE IDEAS DE NEGOCIO
Authors: Moreno-Unibio Carlos Alberto 
Published: December 2023

The knowledge society places young people of all ages in a new social, family, school and work context. For today's youth, ensuring success in life is increasingly important, to facilitate this objective it is essential to develop different transversal skills that complement their training and can improve their productive performance in a work, business or social environment.
For the 21st century, society's desirable competencies are framed in "know-how", such as: analytical and innovation thinking, complex problem solving, critical thinking, creativity, originality and Initiative, resilience, stress tolerance, flexibility, technological appropriation, monitoring and control, design and programming, leadership, social influence, among others.
The competition for innovation stands out in this group, not only as a strategy to generate competitive advantage in companies or the individual, but also to help solve the main universal social problems, especially poverty and unemployment. It is imperative to create strategies for the development of a culture of innovation orchestrated by the youth that will be the protagonist in the society of the 21st century.
Technologies of learning and knowledge (TAC) are the strategic vehicle to help this purpose. TACs, due to their low cost, advanced technological development, and their great hooking power for youth, become an ideal tool for the development of innovation competence, serious digital games stand out within their diverse number of applications.
This research work is focused on demonstrating that the use of serious digital games can develop innovation competence in young university students.
«El privado que nació de su ruina»
Authors: Gomis Juan 
Published: December 2023

Este trabajo propone el análisis comparado de las executions ballads y los romances que dieron cuenta de las caídas de Robert Devereux, conde de Essex, y Rodrigo Calderón, marqués de Siete Iglesias, producidas con una diferencia de veinte años, en 1601 y 1621. En primer lugar, se trazan las semblanzas de ambos personajes, su ascenso político, el ejercicio del poder y las causas que precipitaron su desgracia; a continuación, nos centramos en la punición que sufrieron y su comportamiento en el cadalso, que acabó por convertirse en el emblema de sus vidas; finalmente, se estudian las composiciones que, difundidas en broadsides y pliegos sueltos, configuraron sendos nuevos retratos para Essex y Calderón que perdurarían durante siglos.