bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells
Authors: Larrue Clement , Mouche Sarah , Angelino Paolo , Sajot Maxime , Birsen Rudy , Vergez François , Recher Christian , Mas Véronique Mansat-De , Gu Qiong , Xu Jun , Tsantoulis Petros , Sarry Jean-Emmanuel , Tamburini Jerome 
Published: December 2023

AbstractAcute myeloid leukemia (AML) remains a challenging hematological malignancy with poor prognosis and limited treatment options. Leukemic stem cells (LSCs) contributes to therapeutic failure, post-therapy relapse and adverse outcome. Here, we investigated the role of quiescence and its associated molecular mechanisms in AML pathogenesis and LSCs functions, and identified potential vulnerabilities for therapeutic intervention. We found that LSC-enriched quiescent cell population exhibited a distinct gene set of prognostic significance in AML patients. Furthermore, this quiescent cells subset displayed heightened autophagic activity with a reliance on ferritinophagy, a selective form of autophagy mediated by Nuclear Receptor Coactivator 4 (NCOA4) regulating iron bioavailability. Inhibition of NCOA4 genetically or chemically showed potent anti-leukemic effects, particularly targeting the LSC compartment. These findings uncover that ferritinophagy inhibition may represent a promising therapeutic strategy for patients with AML.One Sentence SummaryTargeting quiescent leukemic stem cells via NCOA4-dependent ferritinophagy inhibition may improve therapeutic outcomes in acute myeloid leukemia.
Disproportion among reticulon-like 16 (RTNLB16) splice variants disrupts growth and decreases sensitivity to ABA and senescence in Arabidopsis
Authors: Khazma Tami , Levi Dikla , Ben-Asher Hiba Waldman , Miller Gad 
Published: December 2023

AbstractThe Reticulon family proteins (RTNs) are membrane-spanning proteins found in the endoplasmic reticulum (ER) with diverse functions, such as ER membrane morphogenesis, vesicle formation, and trafficking. The plant-specific reticulon-like protein family (RTNLBs) comprises multiple members, yet their functions remain poorly understood. The Arabidopsis RTNLB16 gene has seven splice variants, each encoding seven distinct protein isoforms.We identified an Arabidopsis mutant (Salk_122275/rtnlb16-1) as a knockout for the upper coding frame, isoform 7, of RTNLB16 while overexpressing the other six isoforms through the CaMV 35S promoter at the left border of the T-DNA insertion.rtnlb16-1exhibits distinctive growth retardation and reduced chlorophyll levels. Under photoperiodic long day (16:8 h) conditions, activation of the 35S promoter intensifiesRTNLB16expression in the mutant, resulting in profound growth inhibition. Conversely, growth under continuous low-light (CLL) conditions restrains the overexpression and significantly mitigatesrtnlb16-1phenotype. Confocal microscopy experiments revealed the localization of RTNLB16:GFP in the tubular ER network, plasmodesmata, and potentially in Golgi bodies.Peculiarly, RTLB16/rtnlb16heterozygote plants exhibit non-Mendelian reduced fertility, suggesting potential involvement of RTNLB16 in reproductive development. Transcriptomics comparisons betweenrtnlb16-1and the wild type under CLL and 16:8h conditions revealed differential gene expression involved in salicylic acid, jasmonic acid, and abscisic acid responses, indicating activation of defense and osmotic stress responses contributing to the growth inhibition in the mutant. We further demonstrate thatrtnlb16has decreased sensitivity to abscisic acid and enhanced tolerance to darkness-induced senescence.Our findings highlight the importance of balanced expression among RTNLB16 isoforms for normal cellular and physiological activities in Arabidopsis. Additionally, our study underscores the significance of employing T-DNA mutants to investigate genes with multiple splice variants.
Inhibition of MMP 2&9 protects the endothelial glycocalyx and improves diastolic function in diabetic cardiomyopathy
Authors: Buffonge Stanley , Qiu Yan , Fawaz Sarah , Gamez Monica , Crompton Michael , Butler Matthew J , Welsh Gavin I , Madeddu Paolo , Foster Rebecca R , Satchell Simon C 
Published: December 2023

AbstractThe coronary microvascular endothelial glycocalyx (EGlx) is a vital regulator of vascular permeability and EGlx damage contributes to the development of diabetic cardiomyopathy. Matrix metalloproteinases 2 and 9 (MMP2/9) have been identified as key enzymes in the degradation of EGlx components, notably syndecan 4 (SDC4), and are upregulated in diabetes. We tested the hypothesis that inhibition of MMP2/9 can protect the EGlx and improve diastolic function in diabetic cardiomyopathy. Type 1 diabetes was induced in FVB mice by streptozotocin (STZ) injections. Mice were treated with daily injections of the MMP2/9 inhibitor, SB-3CT, for 2 weeks from 7 weeks post STZ. Echocardiography was utilised to assess heart function and lectin staining for the measurement of EGlx depth. Immunolabelling of heart sections for albumin provided an indication of albumin extravasation. A mechanism of EGlx shedding was investigated in vitro in human coronary microvascular endothelial cells treated with TNF-α and SB-3CT. Diabetic mice developed diastolic dysfunction from 6 weeks post STZ. MMP2/9 inhibition reversed diastolic dysfunction, EGlx thinning and albumin extravasation in diabetic animals. In vitro, TNF-α caused an increase in MMP9 activity and SDC4 shedding from human coronary microvascular endothelial cells. Treatment with SB-3CT reduced MMP9 activity and prevented SDC4 shedding. Knockdown of MMP9 expression prevented TNF-α induced SDC4 shedding. This study demonstrates MMP2/9 inhibition as a strategy to protect the EGlx and improve diastolic function in diabetic cardiomyopathy. Our findings suggest new avenues for therapeutic interventions in cardiovascular complications associated with diabetes.Statements and DeclarationsCompeting interestsThe authors have no competing interests to declare that are relevant to the content of this article.
Modeling barriers to adoption of digitization in supply chains using FTOPSIS and its impact on sustainability TBL
Authors: Rane Santosh B. , Abhyankar Gayatri J. , Kirkire Milind Shrikant , Agrawal Rajeev 
Published: December 2023

PurposeThis article aims at - exploring and prioritizing the barriers to adoption of digitization in supply chains (SCs), categorizing them into sustainability triple bottom line (STBL) based upon their direct impact and suggesting digital technologies to address each barrier.Design/methodology/approachA five-phase methodology is used which consists of an exploration of 44 barriers to the adoption of digitization in SCs, analysis of 44 barriers for mean, standard deviation and Cronbach alpha based on questionnaire-based feedback of 25 experts, extraction of 10 most significant barriers through 05 experts, followed by categorization of the barriers into STBL referring to their direct impact on STBL, prioritization of ten barriers using Fuzzy Technique for Order Performance by Similarity to Ideal Solution and recommendation of digital technologies to address each barrier.FindingsWhile all the barriers considered in this study significantly impede the adoption of digitization in SCs, lack of top management commitment (B1) is found to be most crucial while lack of culture toward use of information and communication technology required for digitization (B3) has minimum impact. Large investment in digital infrastructure (B6), difficulty in integration of cyber physical systems (CPSs) on varied platforms (B8) and lack of experts having knowledge of digital technologies (B2) are equally important barriers requiring more attention while adopting digitization in SCs.Research limitations/implicationsThis study is mainly based on feedback from 25 seasoned experts; a wider cross section of experts will give more insight.Practical implicationsThe outcomes are very significant for organizations looking to adopt digitization in their SCs. Simultaneous consideration to all the barriers becomes impractical hence prioritization of same will be useful for the SC managers to benchmark their preparedness and decide strategies for the adoption of digitization with due consideration toward the impact of barriers on STBL. The digital technologies recommended will further aid in planning the digital strategies to address each barrier.Originality/valueA unique approach to explore, analyze, prioritize and categorize the barriers to adoption of digitization in SCs is used to provide a deeper understanding of factors deterring the same. It implies that a supportive top management along with systematic allocation of finances plays a crucial role. The importance of availability of digital experts for integrating CPSs on a single platform is also highlighted. The digital technologies recommended will further assist the organizations toward adoption of digitization in SCs with due consideration to STBL.
Exploring the impact of institutional forces on the social sustainability of logistics service providers: insights from a high terrorism-affected region
Authors: Khan Muhammad Naveed , Rafi-ul-Shan Piyya Muhammad , Akhtar Pervaiz , Khan Zaheer , Shamim Saqib 
Published: December 2023

Purpose
Achieving social sustainability has become a critical challenge in global supply chain networks, particularly during complex crises such as terrorism. The purpose of this study is to explore how institutional forces influence the social sustainability approaches of logistics service providers (LSPs) in high terrorism-affected regions (HTAR). This then leads to investigating how the key factors interact with Institutional Theory.

Design/methodology/approach
An exploratory multiple-case study research method was used to investigate six cases of different-sized logistics LSPs, each in an HTAR. The data was collected using semistructured interviews and triangulated using on-site observations and document analysis. Thematic analysis was used in iterative cycles for cross-case comparisons and pattern matching.

Findings
The findings interact with Institutional Theory and the three final-order themes. First, management processes are driven by coopetition and innovation. Second, organizational resources, structure and culture lead to an ineffective organizational design. Finally, a lack of institutionalization creates institutional uncertainty. These factors are rooted in many other first-order factors such as information sharing, communication, relationship management, capacity development, new process developments, workforce characteristics, technology, microlevel culture and control aspects.

Originality/value
This study answers the call for social sustainability research and enriches the literature on social sustainability, Institutional Theory and LSPs in HTARs by providing illustrations showing that institutional forces act as driving forces for social sustainability initiatives by shaping the current management processes. Conversely, the same forces impede social sustainability initiatives by shaping the current organizational designs and increasing institutional uncertainty.
Talking with venture capitalists: gender perceptions in investment decisions
Authors: Karlstrøm Birgitte , Jansen Tiril Marie , Solheim Marte C.W. 
Published: December 2023

PurposeThe venture capital industry is an important provider of capital to start-ups and has grown considerably in recent decades. This study explores how investors' gender perceptions influence venture capital investment decisions in an industry that remains highly gender imbalanced, both amongst the venture capital decision-makers and with respect to the allocation of capital to entrepreneurs.Design/methodology/approachThe authors' approach was informed by a thorough literature review and in-depth qualitative interviews with ten decision-makers at some of the foremost venture capital funds in Norway. Interviews were recorded, transcribed and coded using NVivo.FindingsThe authors' findings demonstrate that the Norwegian venture capital industry is influenced by homophily and role congruity. The authors highlight the challenges entrepreneurs face in gaining access to venture capital if they are not already members of the investors' network, a situation that results in a recycling effect that helps maintain the industry’s gender imbalance. Moreover, it appears that venture capitalists (VCs) favour masculine characteristics when assessing entrepreneurs, revealing a potential incongruence between female characteristics and perceived entrepreneurial attributes.Originality/valueThe authors' study contributes to and extends the extant literature on homophily and role congruity. Indeed, through investigating the gender-based perceptions of VCs, the authors shed new light on the mechanisms involved in their assessment of entrepreneurs, as well as on the drivers and barriers affecting female entrepreneurs.
Child labor and youth crime: evidence for Brazil
Authors: Santos Fabrício Rios Nascimento , Lírio Viviani Silva , dos Santos Anderson Moreira Aristides 
Published: December 2023

PurposeIn addition to being a violation of human rights, the practice of child labor can be related to criminality against young people. In view of this, the hypothesis tested in this article was that child labor aggravates youth homicide through educational level.Design/methodology/approachThis study used annual data for the 26 states plus the Federal District for the period 2001 to 2014. To do so, the authors used the iterated feasible generalized least squares (IFGLS) estimator under the seemingly unrelated regressions (SUR) model.FindingsThe results showed that child labor positively affects the homicide of young people, showing education as a transmission channel through which the effect is materialized. The general conclusion, given this, that work is an alternative for children not to enter the world of crime due to its socializing character, cannot be sustained.Practical implicationsThis evidence provides input to the formulation of policies and programs to eradicate or slow child labor. In addition to the social and economic rise of individuals, it is important to emphasize the role of education (human capital) in explaining economic growth.Originality/valueSo far, there is no record of national research that sought to empirically assess the effect of child labor on crime, in particular, on the homicide of young people, considering education as a transmission channel, and this assessment is the contribution of the present study to the economic literature on crime.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-03-2023-0163
Exploring collaborative innovation evolution of China’s energy conservation and environmental protection industry: a social network analysis based on patents
Authors: Liu Weiwei , Guo Yuqi , Bi Kexin 
Published: December 2023

Purpose
Energy conservation and environmental protection industry (ECEPI) is a strategic choice to promote energy conservation and emission reduction, develop green economy and circular economy. However, China’s ECEPI is still in the stage of rapid development and the overall scale is relatively small, what development periods have the ECEPI experienced? This study aims to contribute to a better understanding of collaborative innovation evolution based on social network analysis from the perspective of multi-dimensional proximity.

Design/methodology/approach
Methodologically, this study uses social network analysis method to explore the co-evolution of multidimensional collaboration networks. It divides China’s ECEPI into four periods based on national policies from 2001 to 2020. This contribution constructs collaborative innovation networks from geographical, technological and organizational proximity.

Findings
The results show that the collaborative innovation network was initially formed in the central region of China, gradually expanded to neighboring cities and the core positions of Beijing, Jiangsu and Guangdong have been continuously consolidated. C02F has been the core of the collaboration networks, and the research focus has gradually shifted from the treatment of wastewater, sewage or sludge to the separation field. Enterprises always occupy a dominant position in the collaboration networks.

Originality/value
This research investigates the dynamic evolution process of collaborative innovation network in China’s ECEPI from the perspective of multidimensional proximity, explores the community structure, important nodes and multidimensional proximity features in the network, expands the research perspective on evolution characteristics of innovative network and the research field of social network analysis. Theoretically, this study enriches collaborative innovation theory, social network theory and multi-dimensional proximity theory.
Sustainable board governance and sustainable supply chain reporting: European evidence
Authors: Velte Patrick 
Published: December 2023

PurposeThis paper aims to investigate the impact of sustainable board governance, based on (1) sustainability board committees, (2) critical mass of female board members and (3) sustainability-related executive compensation, on sustainable supply chain reporting (SSCR).Design/methodology/approachBased on stakeholder and critical mass theories, a sample of 1,577 firm-year observations for firms listed at the EuroSTOXX600 for the period 2017–2021 is used. Sustainable board governance and SSCR proxies are collected from the Refinitiv database. Correlation and logit regression analyses are conducted to measure the impact of sustainable board governance on SSCR.FindingsSustainable board governance significantly improves SSCR. The findings are robust to various robustness checks, based on the modification of dependent and independent variables.Research limitations/implicationsDue to massive regulations on sustainability reporting, finance and corporate governance, firms listed on the EuroSTOXX 600 are focused in this analysis. The European capital market represents a unique setting for archival research.Practical implicationsEuropean standard setters should connect the relationship between sustainable board governance and SSCR in future regulations, for example, due to the recent corporate sustainability reporting directive (CSRD) and corporate sustainability due diligence directive (CSDDD).Originality/valueTo the best of the author’s knowledge, this paper provides the first analysis on the impact of sustainable board governance on SSCR.
Open science policies as regarded by the communities of researchers from the basic sciences in the scientific periphery
Authors: Manco Alejandra 
Published: December 2023

PurposeThis paper explores the different open science policy effects on the knowledge generation process of researchers in basic sciences: biology, chemistry and physics.Design/methodology/approachThis paper uses a qualitative methodology with a content analysis approach. It uses seventeen semi-directed interviews.FindingsThe main perceived effect of open science is access to research inputs, with open access, open research data and code reuse as primary sources. Another issue is the increase of collaboration with other colleagues in terms of the ability to collaborate faster and encouraging the exchange of ideas. However, this benefit does not translate to the division of labor in large transnational teams. Time spent on tasks like cleaning up data and code, scooping and other ethical issues are unfavorable aspects noted.Practical implicationsPolicymakers could use this study to enhance current open science policies in the countries.Originality/valueThis study analyzes the perspectives of basic sciences researchers from two countries about open science policies. The main conclusion is the fact that open science policies should focus on the research process itself – rather than research outputs – in order to effectively tackle inequalities in science.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-03-2023-0135
Diversity, species coexistence and functional composition patterns in subtropical Atlantic Forests invaded by non‐native trees
Authors: Larsen Janaina Gabriela , da Silva Ana Carolina , de Sá Dechoum Michele , de Freitas Elisete Maria , Gomes Juliano Pereira , Stedille Lilian Iara Bet , Carvalho Joema , Higuchi Pedro 
Published: December 2023

Resumo

Invasões biológicas são um grande desafio ambiental atualmente. Interações entre espécies invasoras e nativas podem moldar significativamente as estruturas da comunidade, influenciando a coexistência, diversidade e composição funcional das espécies. A Floresta Atlântica subtropical no sul do Brasil, um reconhecido hotspot de biodiversidade, oferece um cenário único para estudar essas interações, dada sua vulnerabilidade às invasões de árvores exóticas.

Nosso estudo buscou elucidar os impactos dessas invasões neste ecossistema frágil, abordando questões‐chave: (1) Como os padrões de diversidade da comunidade arbórea são afetados pela abundância de espécies exóticas invasoras? (2) Quais são os padrões de coexistência entre árvores nativas e exóticas invasoras? (3) A composição funcional das florestas é alterada pela abundância de árvores invasoras?

Para abordar essas questões, compilamos dados sobre a abundância e características funcionais de árvores nativas e invasoras. Determinamos os padrões de diversidade e composição funcional de parcelas com diferentes graus de invasão. Estes dados foram analisados usando Modelos Lineares Mistos Generalizados, Análise de Componentes Principais e um índice de coexistência.

Em parcelas com maior abundância de árvores invasoras, houve uma diminuição significativa na riqueza taxonômica e funcional das espécies nativas. Além disso, observamos que árvores exóticas invasoras coexistiam com espécies nativas, e à medida que a abundância de árvores invasoras aumentava, a média ponderada da comunidade nativa (CWM) da área foliar e da área foliar específica diminuía.

Em conclusão, nas áreas da Floresta Atlântica subtropical do sul do Brasil, nossos achados destacam que a abundância de árvores invasoras afeta adversamente a riqueza taxonômica e funcional das espécies nativas. Além disso, enquanto árvores exóticas invasoras foram encontradas coexistindo com espécies nativas, o aumento da abundância invasora correspondeu a uma redução na área foliar e na área foliar específica da comunidade nativa.
From Negative Emotions to Personal Growth: Failure and Re‐entry into Entrepreneurship
Authors: Shore Adam , Pittaway Luke , Bortolotti Thomas 
Published: December 2023

AbstractThis study explores how entrepreneurs’ extent of experience of business failure affects the level of negative emotional response (NER) they experience, moderating the level of personal growth that occurs after business failure. Contrary to common assumption, the study finds no significant relationship between the extent of failure experience and the level of NER. The results show that many entrepreneurs demonstrate personal growth following business failure, however, the extent of failure experience and the level of NER. This interaction moderates the level of personal growth for the entrepreneur and suggests that high levels of failure experience interfere with the level of personal growth obtained. The study contributes to theory by providing insights into the processes and consequences of entrepreneurial failure. In particular, the study brings together key threads of debate on personal growth and failure to develop and test conceptual arguments, and further explores the way entrepreneurship scholars think about emotion, business failure and its impact on the individual and society.