bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of non‐surgical interventions to improve health and well‐being in women living with Mayer–Rokitansky–Kuster–Hauser syndrome: A systematic review
Authors: Baby Anu , Pallam Manju C. , Hayter Mark 
Published: November 2023

AbstractAimThe aim of this paper is to present the evidence on the effectiveness of non‐surgical interventions to improve health and well‐being in women living with Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome.DesignSystematic review guided by Preferred Reporting Items for Systematic Reviews checklist.Data SourcesThe search was conducted between June and September 2022 across the following databases: CINAHL, EMBASE, Medline, PsycINFO and Cochrane. Trial registries (clinicaltrials. gov, World Health Organization International Clinical Trials Registry Platform (ICTRP), Cochrane Controlled Trials Register‐CCTR), Google scholar, dissertations, conference proceedings and reference lists of included studies were also searched. Corresponding authors, formal and informal MRKH groups were contacted to obtain any significant studies or reviews.Review MethodsEligible were only English‐language empirical studies of any time period. The review followed narrative synthesis.ResultsTwenty‐three studies were identified that fit the inclusion criteria which included 1540 MRKH syndrome affected women. Four studies were on psychological interventions (n = 85) and 19 studies (vaginal dilation therapy n = 897, coital dilation n = 57) focused on non‐surgical vaginal dilation as a measure to vaginal agenesis in MRKH syndrome.ConclusionsClearly, vaginal dilation is a viable initial treatment option for women with MRKH syndrome. There is limited evidence that ‘coital dilation’ is an effective method of dilation for vaginal agenesis. The literature, however, supports the need for psychological intervention to improve health and well‐being.ImpactWomen with MRKH syndrome who require dilation can receive guidance and support from their healthcare providers, particularly sexual and reproductive health nurses, clinical nurse specialists and gynaecologists. From the point of diagnosis, clinical psychologists should be involved. As much as feasible, family and partner support can be encouraged.Patient or Public ContributionNo patient or public contribution.
Phenomenography: A useful methodology for midwifery research
Authors: Balding Kirstie Jayne , Geraghty Sadie , Timler Amanda , Pezaro Sally , McChlery Sheena 
Published: November 2023

AbstractAimsTo outline the theoretical, philosophical, and major assumptions associated with phenomenography and then address the application of a phenomenographical approach within the context of midwifery research.BackgroundPhenemonography is a little‐known qualitative research approach amongst the main design traditions of phenomenology, grounded theory, case study, and ethnography more typically used within midwifery research. Phenomenography aims to describe the qualitatively different ways that people perceive, conceptualize, or experience a phenomenon. Phenemonography has a distinctly different approach from other qualitative methods as it places emphasis on the ‘collective’ meaning over individual experience.MethodologyPhenomenography, as an approach, rests within the interpretivist paradigm recognizing that there are multiple interpretations of reality. Phenomenography emphasizes the various ways that people experience the same phenomenon, including both the similarities and differences. The second‐order perspective embraced by phenomenography suggests that the researcher directs themselves towards people's understanding of the world; essentially the world is described as it is understood rather than as it is. It is the reporting about how these different realities appear at a collective level that is the output of phenomenographic research.FindingsA framework for conducting phenomenographic research is illustrated by outlining the steps within the methodological approach required to undertake a research study using phenemonography.ConclusionPhenomenography is a qualitative research approach that can usefully be applied in many midwifery contexts where a collective understanding of a phenomena is required. Using a phenomenographic approach can provide the midwifery profession with knowledge about variations in how women and midwives think, and how aspects of different phenomena are experienced in within a midwifery setting.
Researching belonging in the context of research with people with intellectual disabilities: A systematic review of inclusive approaches
Authors: Garcia‐Lee Benjamin , Strnadová Iva , Dowse Leanne 
Published: November 2023

AbstractBackgroundIn disability studies belonging is emerging as a promising area of study. Inclusive research, based as it is on lived experience perspectives, is likely to provide salient insights into belonging in the lives of people with intellectual disabilities.MethodA systematic review utilising four databases and five leading journals in the field of intellectual disabilities was used. Content analysis and a deductive synthesis of the extracted data was undertaken.ResultsA high level of confluence was found between the findings of the included studies and key themes of belonging identified in the wider literature. Beyond this, studies utilising inclusive research approaches have contributed novel findings about belonging in the lives of people with intellectual disabilities.ConclusionsInclusive research approaches to belonging may provide innovative and responsive frameworks to support people to develop a sense of being connected and “at home” in themselves and in their communities.
Precautions and possibilities in orthodontic treatment of periodontally compromised patients: Current recommendations
Authors: Han Sung‐Hoon , Ko Youngkyung , Ham Lyun Kwang , Park Jae Hyun , Kim Yoonji 
Published: November 2023

AbstractObjectiveOrthodontic treatment plays a crucial role in achieving optimal dental esthetics and functional occlusion. However, when periodontally compromised patients are involved, additional precautions and considerations are critical. This article aims to provide up‐to‐date recommendations for the orthodontic treatment of periodontally compromised patients.Clinical ConsiderationsComprehensive diagnosis of the patient's periodontal status, inherent malocclusion, and secondary malocclusion resulting from periodontal disease are essential for achieving optimal esthetics and functional occlusion. This can be facilitated through the use of a simplified checklist. Prior to orthodontic treatment, pre‐existing periodontal diseases should be managed. Light and controlled forces should be used to minimize the risk of adverse effects on the periodontium, and any potential traumatic occlusion during tooth movement should be minimized. Furthermore, careful anchorage management is required, and proper application of temporary anchorage devices can significantly expand the scope of orthodontic treatment. Finally, treatment results are maintained by ongoing supportive periodontal therapy even during the retention period.ConclusionsThis article presents clinical cases demonstrating the importance of accurate diagnosis in orthodontics and periodontics and the positive impact of orthodontic treatment on patients with pre‐existing periodontal diseases.Clinical SignificanceAn up‐to‐date orthodontic treatment protocol for periodontally compromised patients is presented.
Evaluation of mechanical, optical, and fluoride‐releasing properties of a translucent bulk fill glass hybrid restorative dental material
Authors: Moshaverinia Maryam , de Almeida Queiroz Ferreira Luiza , Smidt Greta , Shah Kumar C. , Ansari Sahar , Moshaverinia Alireza 
Published: November 2023

AbstractObjectiveMeasure and compare the mechanical properties, translucency, and fluoride‐releasing capabilities of EQUIA Forte HT against Fuji IX GP and ChemFil Rock.Materials and MethodsTen specimens of each material were fabricated for compressive strength (CS), flexural strength (FS), and surface hardness analysis at 24 h and 7 days. The L*a*b* values were measured against a black‐and‐white background using a spectrophotometer to analyze the translucency parameter (TP). Fluoride release was recorded after 2 months of immersion in distilled water. The mean data was analyzed by 1‐ and 2‐way ANOVA (α = 0.5).ResultsEQUIA Forte HT showed higher CS, surface hardness, and FS values (p < 0.05) compared with Fuji IX GIC, while no significant difference was found in FS values between EQUIA Forte HT and Chemfil Rock (p > 0.05). The EQUIA Forte HT exhibited significantly higher translucency in comparison to both ChemFil Rock (p < 0.001) and Fuji IX GICs (p < 0.05). An increase (p > 0.05) of fluoride release was observed for EQUIA Forte HT.ConclusionThe EQUIA Forte HT Glass‐ionomer cements (GIC) offers enhanced translucency, improved strength, and enhanced fluoride‐releasing properties compared to the traditionally used Fuji IX GIC and ChemFil Rock GICs. This material might have a wide range of clinical applications due to its improved strength and optical properties.Clinical SignificanceGlass‐ionomer dental restorative materials possess unique advantageous characteristics. However, its poor mechanical and optical properties have typically limited its clinical applications. Efforts to improve these properties have resulted in enhanced GICs. EQUIA Forte HT GIC offers enhanced mechanical and optical properties with potential applications in posterior and anterior restorative procedures.
From Fixed‐Event to Fixed‐Horizon Density Forecasts: Obtaining Measures of Multihorizon Uncertainty from Survey Density Forecasts
Authors: GANICS GERGELY , ROSSI BARBARA , SEKHPOSYAN TATEVIK 
Published: November 2023

AbstractThe U.S. Survey of Professional Forecasters produces precise and timely point forecasts for key macro‐economic variables. However, the accompanying density forecasts are mostly conducted for “fixed events.” For example, in each quarter, panelists predict output growth and inflation for the current calendar year and the next, hence the forecast horizon changes with each survey round. This limits the forecasts' usefulness to policymakers, researchers, and market participants. We propose a density combination approach that weights fixed‐event density forecasts, aiming at obtaining a correctly calibrated fixed‐horizon density forecast. We show that our method produces competitive density forecasts relative to widely used alternatives.
Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis
Authors: Ohkawara Bisei , Kurokawa Masaomi , Kanai Akinori , Imamura Kiyomi , Chen Guiying , Zhang Ruchen , Masuda Akio , Higashi Koichi , Mori Hiroshi , Suzuki Yutaka , Kurokawa Ken , Ohno Kinji 
Published: November 2023

AbstractSkeletal muscle fiber is a large syncytium with multiple and evenly distributed nuclei. Adult subsynaptic myonuclei beneath the neuromuscular junction (NMJ) express specific genes, the products of which coordinately function in the maintenance of the pre‐ and post‐synaptic regions. However, the gene expression profiles that promote the NMJ formation during embryogenesis remain largely unexplored. We performed single‐nucleus RNA sequencing (snRNA‐seq) analysis of embryonic and neonatal mouse diaphragms, and found that each myonucleus had a distinct transcriptome pattern during the NMJ formation. Among the previously reported NMJ‐constituting genes, Dok7, Chrna1, and Chrnd are specifically expressed in subsynaptic myonuclei at E18.5. In the E18.5 diaphragm, ca. 10.7% of the myonuclei express genes for the NMJ formation (Dok7, Chrna1, and Chrnd) together with four representative β‐catenin regulators (Amotl2, Ptprk, Fam53b, and Tcf7l2). Additionally, the temporal gene expression patterns of these seven genes are synchronized in differentiating C2C12 myoblasts. Amotl2 and Ptprk are expressed in the sarcoplasm, where β‐catenin serves as a structural protein to organize the membrane‐anchored NMJ structure. In contrast, Fam53b and Tcf7l2 are expressed in the myonucleus, where β‐catenin serves as a transcriptional coactivator in Wnt/β‐catenin signaling at the NMJ. In C2C12 myotubes, knockdown of Amotl2 or Ptprk markedly, and that of Fam53b and Tcf7l2 less efficiently, impair the clustering of acetylcholine receptors. In contrast, knockdown of Fam53b and Tcf7l2, but not of Amotl2 or Ptprk, impairs the gene expression of Slit2 encoding an axonal attractant for motor neurons, which is required for the maturation of motor nerve terminal. Thus, Amotl2 and Ptprk exert different roles at the NM compared to Fam53b and Tcf7l2. Additionally, Wnt ligands originating from the spinal motor neurons and the perichondrium/chondrocyte are likely to work remotely on the subsynaptic nuclei and the myotendinous junctional nuclei, respectively. We conclude that snRNA‐seq analysis of embryonic/neonatal diaphragms reveal a novel coordinated expression profile especially in the Wnt/β‐catenin signaling that regulate the formation of the embryonic NMJ.image
Risk, trust, and altruism in genetic data sharing
Authors: Samad Zeeshan , Wooders Myrna , Malin Bradley , Vorobeychik Yevgeniy 
Published: November 2023

AbstractHow does concern about genetic data privacy compare with other concerns? We conduct behavioral experiments to compare risk attitudes towards sharing genetic data with a healthcare provider with risk attitudes towards sharing financial data with a money manager. Both scenarios involve identical decisions and monetary stakes, permitting us to focus on how the framing of data sharing influences attitudes. To delve deeper into individual motivations to share data, we provide treatments that study how data sharers' altruism and trust affect their decisions. Our findings (with 162 subjects) indicate that individuals are more willing to risk a loss to privacy of genetic data (for an anticipated return framed as health benefits) than they are to risk loss of financial data (for an anticipated return in financial benefits). We also find that 50%–60% of data recipients choose to protect another person's data, with no significant differences between frames.
The effect of maternal organic manganese supplementation on performance, immunological status, blood biochemical and antioxidant status of Afshari ewes and their newborn lambs in transition period
Authors: Asadi Mohammad , Toghdory Abdolhakim , Ghoorchi Taghi , Hatami Maryam 
Published: November 2023

AbstractIt has been documented that adequate maternal manganese (Mn) status is vital for performance and health of ewes and their newborn lambs. However, required level and form of dietary Mn in ruminants are not well defined. The current study was conducted to evaluate the effect of maternal organic Mn supplementation on performance, immunological status, blood biochemical and antioxidant status of Afshari ewes and their newborn lambs in transition period. For this purpose, various organic Mn concentrations were utilized as a supplementary ingredient in formulating the diets of ewes. The ewes were randomly allocated into three groups, fed with 0, and 80 mg/kg organic Mn supplemented diet. At the end of the experiment, the parameters including the performance of newborn lambs, as well as biochemical factors, immune status and antioxidant status in ewes and their newborn lambs were evaluated. The results showed a significant increase in the plasma concentrations of Mn, glucose, insulin, thyroid hormones (T3, T4) and enzymatic antioxidants (SOD, GPX, CAT) in ewes and their newborn lambs that were treated with maternal organic Mn. Moreover, inorganic Mn treatments, the concentration of IgG in newborn lamb's plasma, and colostrum of ewes increased. According to this research, organic Mn acts as a valuable and safe supplementary material that could be exploited for enhancing health of ewes and their newborn lambs.
Preclinical evaluation of a new synthetic carbonate apatite bone substitute on periodontal regeneration in intrabony defects
Authors: Imber Jean‐Claude , Imber Larissa Carmela , Roccuzzo Andrea , Stähli Alexandra , Muñoz Fernando , Weusmann Jens , Bosshardt Dieter Daniel , Sculean Anton 
Published: November 2023

AbstractObjectiveTo evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap‐BS) on periodontal regeneration.BackgroundThe use of various synthetic bone substitutes as a monotherapy for periodontal regeneration mainly results in a reparative healing pattern. Since xenografts or allografts are not always accepted by patients for various reasons, a synthetic alternative would be desirable.MethodsAcute‐type 3‐wall intrabony defects were surgically created in 4 female beagle dogs. Defects were randomly allocated and filled with CO3Ap‐BS (test) and deproteinized bovine bone mineral (DBBM) or left empty (control). After 8 weeks, the retrieved specimens were scanned by micro‐CT, and the percentages of new bone, bone substitute, and soft tissues were evaluated. Thereafter, the tissues were histologically and histometrically analyzed.ResultsHealing was uneventful in all animals, and defects were present without any signs of adverse events. Formation of periodontal ligament and cementum occurred to varying extent in all groups without statistically significant differences between the groups. Residues of both bone substitutes were still present and showed integration into new bone. Histometry and micro‐CT revealed that the total mineralized area or volume was higher with the use of CO3Ap‐BS compared to control (66.06 ± 9.34%, 36.11 ± 6.40%; p = .014, or 69.74 ± 2.95%, 42.68 ± 8.68%; p = .014). The percentage of bone substitute surface covered by new bone was higher for CO3Ap‐BS (47.22 ± 3.96%) than for DBBM (16.69 ± 5.66, p = .114).ConclusionsCO3Ap‐BS and DBBM demonstrated similar effects on periodontal regeneration. However, away from the root surface, more new bone, total mineralized area/volume, and higher osteoconductivity were observed for the CO3Ap‐BS group compared to the DBBM group. These findings point to the potential of CO3Ap‐BS for periodontal and bone regeneration.
SNP genotyping revealed a hybrid zone between Mytilus chilensis and M. platensis in southern South America (the Strait of Magellan, Isla Grande de Tierra del Fuego and the Falkland Islands)
Authors: Jilberto Felipe , Zbawicka Malgorzata , Wenne Roman , Larraín María Angélica , Araneda Cristián 
Published: November 2023

AbstractHybrid zones among mussel species have been extensively studied in the northern hemisphere. In South America, it has only recently become possible to study the natural hybrid zones, due to the clarification of the taxonomy of native mussels of the Mytilus genus. Analysing 54 SNP markers, we show the genetic species composition and admixture in the hybrid zone between M. chilensis and M. platensis in the southern end of South America. Bayesian, non‐Bayesian clustering and re‐assignment algorithms showed that the natural hybrid zone between M. chilensis and M. platensis in the Strait of Magellan, Isla Grande de Tierra del Fuego and the Falkland Islands shows clinal architecture. The hybrid zone can be divided into three different areas: the first one is on the Atlantic coast where only pure M. platensis and hybrid were found. In the second one, inside the Strait of Magellan, pure individuals of both species and mussels with variable degrees of hybridisation coexist. In the last area at the Strait in front of Punta Arenas City, fjords on the Isla Grande de Tierra del Fuego, and at the Beagle Channel, only M. chilensis and a low number of hybrids were found. According to the proportion of hybrids, bays with protected conditions away from strong currents would give better conditions for hybridisation. We do not find evidence of any other mussel species such as M. edulis, M. galloprovincialis, M. planulatus or M. trossulus in the zone.
Examining trajectories of marital satisfaction to represent the resilience process among Indonesian married individuals
Authors: Surijah Edwin Adrianta , Murray Kate , Wraith Darren , Shochet Ian 
Published: November 2023

AbstractMarriage is an important milestone for many adults, and notably in Indonesia, where marriage is also considered a personal accomplishment and social obligation. Research has found being married is associated with greater well‐being, but marriages also face challenges. Resilience, defined as successfully adapting to challenges, is a potential concept to help married individuals maintain or regain adaptation despite challenges in marriages. This is the first relationship study in Indonesia to examine resilience trajectories as represented by marital satisfaction. A weekly repeated measure design was conducted among 135 Indonesian married individuals. Participants reported their experiences of intradyadic and extradyadic stress, and marital satisfaction over 6 weeks. Growth mixture modeling and multinomial logistic regression were used to examine unobserved marital satisfaction trajectories and to estimate the impact of intradyadic and extradyadic stress on trajectory membership. Results suggested three unobserved trajectories: high, moderate, and low levels of marital satisfaction. Higher levels of intradyadic and extradyadic stress increased the probability of belonging to lower satisfaction trajectories. This evidence could be invaluable in helping Indonesian married individuals to better adapt to challenges they face. Future studies can explore protective factors associated with a high satisfaction trajectory to assist married Indonesians in successfully adapting to stress.
Trait variation along an urban–rural gradient in Asian dayflower: the contribution of phenotypic plasticity and genetic divergence
Authors: Taichi N. , Ushimaru A. 
Published: November 2023

Abstract

Environmental changes associated with urbanisation can exert pressure that facilitates both adaptations and plastic responses in plants. Field surveys or common garden experiments (CGE) alone cannot differentiate between the observed phenotypic traits resulting from plastic responses versus evolutionary adaptations to urban environments.

We conducted a field survey of habitat environmental factors and four vegetative traits in 12 Commelina communis populations along an urban–rural gradient in the Osaka‐Kobe megacity area. We collected seedlings from six of the 12 populations, transplanted them into a greenhouse, and measured six vegetative traits. We investigated correlations between pairs of measured traits in both the field survey and CGE.

Plant height and leaf area increased significantly in increasingly developed land areas (DLA) in the field survey, whereas no such variations were found in the CGE, suggesting that the observed phenotypic variation was due to a plastic response to urban eutrophication. Leaf number and specific leaf area (SLA) significantly decreased with increasing DLA in the CGE, suggesting the adaptation of these traits to urban environments. Positive correlations between plant height and leaf area were only observed in urban populations in both the field survey and CGE, indicating the evolution of this trait correlation in urban environments.

It has been suggested that urban environments promote both plastic response and genetic divergence of a set of traits in native plants. Our findings suggest that low leaf number, SLA, and positive plant height–leaf area correlations have evolved. In addition, larger plant size is achieved via phenotypic plasticity in urban environments.