bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability
Authors: Ali Hussain , Muthudoss Prakash , Chauhan Chirag , Kaliappan Ilango , Kumar Dinesh , Paudel Amrit , Ramasamy Gobi 
Published: December 2023

AbstractData variations, library changes, and poorly tuned hyperparameters can cause failures in data-driven modelling. In such scenarios, model drift, a gradual shift in model performance, can lead to inaccurate predictions. Monitoring and mitigating drift are vital to maintain model effectiveness. USFDA and ICH regulate pharmaceutical variation with scientific risk-based approaches. In this study, the hyperparameter optimization for the Artificial Neural Network Multilayer Perceptron (ANN-MLP) was investigated using open-source data. The design of experiments (DoE) approach in combination with target drift prediction and statistical process control (SPC) was employed to achieve this objective. First, pre-screening and optimization DoEs were conducted on lab-scale data, serving as internal validation data, to identify the design space and control space. The regression performance metrics were carefully monitored to ensure the right set of hyperparameters was selected, optimizing the modelling time and storage requirements. Before extending the analysis to external validation data, a drift analysis on the target variable was performed. This aimed to determine if the external data fell within the studied range or required retraining of the model. Although a drift was observed, the external data remained well within the range of the internal validation data. Subsequently, trend analysis and process monitoring for the mean absolute error of the active content were conducted. The combined use of DoE, drift analysis, and SPC enabled trend analysis, ensuring that both current and external validation data met acceptance criteria. Out-of-specification and process control limits were determined, providing valuable insights into the model’s performance and overall reliability. This comprehensive approach allowed for robust hyperparameter optimization and effective management of model lifecycle, crucial in achieving accurate and dependable predictions in various real-world applications.Graphical Abstract
A Novel Case of Concomitant PHEX and ALPL Mutation In a Family With Rickets
Authors: Polanco Santos Carmen , Cordero Garate Juana , Zeinab Khan Leila 
Published: December 2023

Abstract
Currently, no published cases report concomitant X-linked hypophosphatemia (XLH) and adult hypophosphatasia (HPP). Both diseases share clinical phenotypes that are almost indistinguishable. The correct diagnosis may be missed without a standardized laboratory and genetic testing approach. Pathogenic variants in the phosphate regulating endopeptidases homolog X-linked gene (PHEX) and the tissue-nonspecific alkaline phosphatase gene (ALPL) are genes that cause XLH and HPP, respectively. We describe a concomitant yet undescribed genetic pathogenic variant in a family. A 61-year-old woman was referred by orthopedic surgery for the presence of bilateral leg bowing and short stature during the assessment of knee surgery. The patient had a biochemical workup relevant for low serum phosphorus and 1,25-dihydroxy vitamin D and normal alkaline phosphatase (ALP). Genetic analysis revealed pathogenic variants in PHEX and ALPL. Her 42-year-old daughter shared identical symptoms and genetic variants with her mother. Both patients started conventional treatment for XLH with phosphorus and vitamin D, and the daughter later switched to burosumab-twza. Adult XLH and HPP may have similarities in clinical presentation but differ in some essential laboratory findings. Normal ALP levels helped direct our diagnosis toward XLH. However, the diagnosis was challenging due to the presence of concurrent variants in the genes involved. These variants illustrate the significant heterogeneity of the clinical expression.
COveRs to impRove EsthetiC ouTcome after Surgery for Chronic subdural hemAtoma by buRr hole trepanation—Results of a Swiss Single-Blinded, Randomized Controlled Trial
Authors: Stienen Martin N. , Akeret Kevin , Vasella Flavio , Velz Julia , Jehli Elisabeth , Voglis Stefanos , Bichsel Oliver , Smoll Nicolas R. , Bozinov Oliver , Regli Luca , Germans Menno R. 
Published: December 2023

BACKGROUND AND OBJECTIVES:
Burr hole trepanation to evacuate chronic subdural hematoma (cSDH) results in bony skull defects that can lead to skin depressions. We intend to study the effect of burr hole covers to prevent skin depressions and improve the esthetic result.

METHODS:
In a randomized trial, we enrolled adult patients with symptomatic cSDH. Patients received burr hole trepanation with (intervention) vs without burr hole covers (control) in a 1:1 ratio. Patients requiring evacuation of bilateral cSDHs served as their internal control. Primary outcome was satisfaction with the esthetic result of the scar, measured from 0 (dissatisfied) to 10 (very satisfied) on the Esthetic Numeric Analog (ANA) scale at 90 days. Secondary outcomes included ANA scale, rates of skin depression, complications, as well as neurological, disability, and health-related quality of life outcomes until 12 months.

RESULTS:
We included 78 patients (55 with unilateral and 23 with bilateral cSDH; median age 78 years, 83% male) between 03/2019 and 05/2021, 50 trepanations for the intervention and 51 for the control group. In an intention-to-treat analysis, the ANA scale scores were 9.0 (intervention) and 8.5 (control arm) at 90 days (P = .498). At 12 months, the ANA scale scores were 9.0 and 8.0 for the intervention and control groups, respectively (P = .183). Skin depressions over the frontal burr hole were noted by 35% (intervention) and 63% (control) of patients at 90 days (P = .009) and by 35% and 79% (P < .001) at 12 months, respectively. There were no differences in complications, neurological, disability, and health-related quality of life outcomes.

CONCLUSION:
Satisfaction with the esthetic result of the scar was inherently high. This study does not show evidence for improvement on the ANA scale by applying a burr hole cover. The application of burr hole covers resulted in less skin depressions and did not negatively affect complication rates or outcomes.
Through the looking glass: attempting to predict future opportunities and challenges in experimental biology
Authors: Gilmour Kathleen M. , Daley Monica A. , Egginton Stuart , Kelber Almut , McHenry Matthew J. , Patek Sheila N. , Sane Sanjay P. , Schulte Patricia M. , Terblanche John S. , Wright Patricia A. , Franklin Craig E. 
Published: December 2023

ABSTRACT
To celebrate its centenary year, Journal of Experimental Biology (JEB) commissioned a collection of articles examining the past, present and future of experimental biology. This Commentary closes the collection by considering the important research opportunities and challenges that await us in the future. We expect that researchers will harness the power of technological advances, such as ‘-omics’ and gene editing, to probe resistance and resilience to environmental change as well as other organismal responses. The capacity to handle large data sets will allow high-resolution data to be collected for individual animals and to understand population, species and community responses. The availability of large data sets will also place greater emphasis on approaches such as modeling and simulations. Finally, the increasing sophistication of biologgers will allow more comprehensive data to be collected for individual animals in the wild. Collectively, these approaches will provide an unprecedented understanding of ‘how animals work’ as well as keys to safeguarding animals at a time when anthropogenic activities are degrading the natural environment.
Blue-light-enhanced avalanche photodiode with a multi-finger grating structure for fluorescence detection
Authors: Cao Zhixiang , Yang Jian , Wang Yang , Mao Ruiqian , Yi Rongqing , Jin XiangLiang 
Published: December 2023

The responsiveness of the photodetectors is critical to the accuracy of the fluorescent fiber optical temperature sensor. However, the current gain and signal-to-noise ratio (SNR) of traditional photodiodes (PDs) is low, which makes it difficult to meet the high-precision detection requirements of the system. In response to the above problems, this paper achieves a novel, to the best of our knowledge, multi-finger grating (MFG) avalanche photodiode (APD). The device combines the polysilicon gate and the space charge region formed by P+/N-Well to detect photon signals. The conversion capability of the photodetector can be significantly enhanced by the MFG structure. The principle of the device is simulated and verified by technology-computer-aided design (TCAD). The standard grating APD (SG-APD), 2-finger grating APD (2FG-APD), 3-finger grating APD (3FG-APD), and 4-finger grating APD (4FG-APD) are fabricated based on 0.18 µm CMOS process. The optoelectronic detection characteristics of these devices are analyzed by establishing an optoelectronic test platform. At 480 nm, the responsivity of 2FG-APD, 3FG-APD, and 4FG-APD increases by 79.3%, 96.9%, and 70.2%, respectively, compared to SG-APD (4.021 A/W). The test results indicate that 3FG-APD exhibits a strong photon response in the blue light range. The device has broad application prospects in the field of fluorescence detection.
Online psychoeducation and digital assessments as a first step of treatment for borderline personality disorder: A protocol for a pilot randomized controlled trial
Authors: Choi-Kain Lois W. , Murray Grace E. , Jurist Julia , Ren Boyu , Germine Laura 
Published: December 2023

Background
Treatment trials for borderline personality disorder (BPD) have consistently demonstrated that approaches that are diagnostically tailored are superior to those which are not. Currently, gold standard treatments for BPD are highly intensive, lengthy, and specialized, leading to a critical gap between the supply and demand of effective, evidence-based treatment for patients who receive a diagnosis of BPD. Psychoeducation, which is a common component of most treatments known to be effective, is a low-cost, low-burden intervention proven to relieve symptoms. The present study builds on psychoeducation research, assessing online video prescriptions as a means of disseminating information patients need to know about their diagnosis and care.

Methods
This article presents the study protocol for a safety, feasibility, and preliminary efficacy trial of psychoeducational video prescriptions and online assessment with feedback for newly diagnosed individuals with BPD. We aim to recruit 100 adults recently diagnosed with BPD to be randomly assigned to receive videos about BPD or videos about non-BPD mental health topics that are matched in length in the first step of the study. All participants will complete daily surveys about their emotions, interpersonal interactions, and behaviors, as well as self-report assessments and cognitive tests at 4 different time points. Half of the participants in the intervention group will receive feedback on their symptom ratings and cognitive test performance to assess whether there is incremental value in tailoring this online set of interventions with individualized feedback unique to each participant. This study aims to assess the effects of BPD-focused psychoeducational videos with and without personalized feedback, on BPD and depressive symptom severity as well as core mechanisms of the disorder such as loneliness, rejection sensitivity, cognitive control difficulties, and self-clarity. Results will inform efforts to progress to a larger, more definitive trial.

Trial registration
Clinical trials registration: The protocol is registered with ClinicalTrials.gov NCT05358925.
Mat og måltid som symbol for modring
Authors: Hovde Johannesen Elisabeth , Nordahl Julie 
Published: December 2023

Food and Meals as Symbols for Mothering: An Analysis of the Picturebooks Mor by Kim Fupz Aakeson and Mette-Kirstine Bak and Stripekalven by Marit Kaldhol and Justyna Nyka
In this article, we analyze the picturebooks Mor (Mother, 1998) by Kim Fupz Aakeson and Mette-Kirstine Bak and Stripekalven (The Striped Calf, 2008) by Marit Kaldhol and Justyna Nyka based on the following question: How do Mor and Stripekalven treat food and meals as markers for both positive and negative aspects of mothering? In the analysis, we draw on, among others, Ulla M. Holm’s theory of mothering as a type of care practice and examine the four different women that act in the books. Our main finding is that the women, who end up practicing mothering, are complex and composite: they are capable of nurturing the children as well as themselves. Our study also reveals that care practices are portrayed as challenging when children are opposed to receiving them. Lastly, we conclude that the female characters in the books who qualify as mothers are ambivalent figures and not unequivocally good.
”Det verkar vara en klurig fråga”
Authors: Dybvik Hilde , Undheim Inga Henriette 
Published: December 2023

”It Seems to Be a Complicated Question”: Humor as Strategy in Scandinavian Facts-of-Life-Books
The aim of this article is to examine how a selection of Scandinavian children’s books, spanning from the 1970s up until today, have addressed questions concerning where children come from. Previous research has shown that various forms of humor have been used in the dissemination of information on intercourse and conception. In our article, we examine how and why humor is used when presenting adult sexuality in books for children. We consider humor to be a strategy to take the edge off a challenging topic. However, this strategy does not come without a cost. With the help of critical theory and humor theory, we problematize the strategic use of humor, as it may contribute to the reproduction of heteronormative notions and patterns. In the article, we map several recurring tactics, which we have categorized into five humoristic expressions: transgression of taboos, humorous recognition, absurd humor, naivistic humor, and anthropomorphic humor.
Relationship between second language vocabulary knowledge and vocabulary learning strategy use: a meta-analysis of correlational studies
Authors: Ueno Shotaro , Takeuchi Osamu 
Published: December 2023

Abstract
This study examined the relationship between vocabulary knowledge and vocabulary learning strategies (VLSs). We conducted a meta-analysis and integrated 159 effect sizes from 25 studies on the correlation between vocabulary knowledge and VLS use. These effect sizes were subjected to a quantitative analysis that measured the extent to which the correlation differed by type of vocabulary knowledge (size vs. depth), vocabulary measurement (size vs. level), and strategy (direct vs. indirect). The results show a small correlation between vocabulary knowledge and VLS use (r = 0.24). The relationship also differed by type of vocabulary knowledge (r = 0.03–0.35 for size; r = 0.15–0.40 for depth), vocabulary measure (r = 0.03–0.43 for size; r = 0.10–0.50 for level), and strategy type (r = 0.03–0.50). The discussion provides possible justifications for the meta-analysis results and recommendations for future VLS studies.
Evaluation of the optimum safety performance of the nuclear reactor compact grounding system under lightning strikes and ground fault
Authors: Adail Ahmed S. , Saad Mohamed H. , Said Abdelrahman 
Published: December 2023

Abstract
The electrical system of a nuclear reactor facility (NRF) must incorporate a grounding grid in order to ensure it functions safely and reliably. Any disturbance in the electrical system affects the nuclear process, so it is, therefore, crucial to estimate the safety performance of the research nuclear reactor facility grounding system. The paper discusses CYMGrd 6.3, which is based on IEEE Standard 80-2013, and the optimization approaches for finding the best grounding grid design for a nuclear reactor facility connected substation of 500/11 kV in the case of a ground fault and lightning strikes. The result shows that the surface, step and touch potentials along the diagonal coordinates of the proposed grounding grid are below the safety limits in case of a ground fault but also results indicate that 100 kA lightning stroke poses a considerable threat to reactor equipment and personnel safety because the measured grid surface potential exceeds the safe ground potential rise of 3.2 kV standard at the striking point in conjunction with the proposed ground grid, so it must be modified. In this paper, three different optimization algorithms are investigated in order to determine the optimal design of the grounding grid with respect to mesh size: gradient method (GM), the genetic algorithm (GA), and simulated annealing (SA). These methods are used to achieve the purpose of obtaining an effective ground grid design. Comparing these techniques of GM and SA is good for quickly locating local minima, but they may fail to identify global solutions. In contrast, a genetic algorithm is often excellent at achieving a global minimum. Also, the utilization of GA, SA, and GM achieve the reduction of the surface potential of a proposed grounding grid by 16 %, 10 %, and 6 % respectively.
Crystal structure of langite from Mine du Pradet (France)
Authors: Paulsen Christian , Galéa-Clolus Valérie , Pöttgen Rainer 
Published: December 2023

Abstract
Cu4(OH)6SO4·2H2O, monoclinic, Pc (no. 7), a = 7.1026(2) Å, b = 6.0143(1) Å, c = 11.1645(3) Å, β = 90.1103(8)°, V = 476.91(2) Å3, Z = 2, R

gt
(F
2) = 0.0206, wR

ref
(F
2) = 0.0563, T = 100 K.
Crystal structure of 4-bromo-2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, C13H7BrClF3N2
Authors: Qin Jia-Rui , Tang Wen-Hao , Li Kai , Pan Hai-Yu 
Published: December 2023

Abstract
C13H7BrClF3N2, monoclinic, P21/c (no. 14), a = 9.4183(18) Å, b = 15.185(3) Å, c = 13.1826(18) Å, β = 133.905(8)°, V = 1358.4(4) Å3, Z = 4, R

gt
(F) = 0.0420, wR

ref
(F
2) = 0.1015, T = 293 K.
Artificial Neural Networks and Time Series of Counts: A Class of Nonlinear INGARCH Models
Authors: Jahn Malte 
Published: December 2023

Abstract
Time series of counts are frequently analyzed using generalized integer-valued autoregressive models with conditional heteroskedasticity (INGARCH). These models employ response functions to map a vector of past observations and past conditional expectations to the conditional expectation of the present observation. In this paper, it is shown how INGARCH models can be combined with artificial neural network (ANN) response functions to obtain a class of nonlinear INGARCH models. The ANN framework allows for the interpretation of many existing INGARCH models as a degenerate version of a corresponding neural model. Details on maximum likelihood estimation, marginal effects and confidence intervals are given. The empirical analysis of time series of bounded and unbounded counts reveals that the neural INGARCH models are able to outperform reasonable degenerate competitor models in terms of the information loss.
Study of L-tryptophan (a neurotransmitter precursor): spectral, Hirshfeld surface, molecular docking and dynamics simulations
Authors: Fatima Aysha , Kumar Anuj , Saral Abdul Kadar Avuliya , Muthu Sambantham , Afzal Mohd , Haq Nazrul , Nazar Imran , Siddiqui Nazia , Javed Saleem 
Published: December 2023

Abstract
This paper describes both theoretical and empirical studies on essential amino acids and the serotonin precursor L-tryptophan. To analyze the molecular structure, the FTIR technique 1H NMR, and ultraviolet–visible spectroscopy were performed. The current research used the DFT – B.3.L.Y.P/6-311++G(d,p) methodology to enhance an essential amino acid in the electronic ground state. The spectral studies of the chosen compound were analyzed in gaseous state and various solvent phases, and the outputs were then related with observed experimental information using the Time dependent-DFT methodology. NBO analysis was employed to determine the stabilization energies and electronic transitions. MEP and ELF analyses were accomplished to understand the chemically responsive regions of molecule. Thermodynamic functions of the title chemical are also known at various temperatures. 3D Hirshfeld surface studies and two-dimensional fingerprint images were utilized to offer a thorough explanation of the crystal surface’s interactions with other molecules. To investigate protein-ligand interactions, least binding energy was measured as −7.2 kcal mol−1 in molecular docking. L-Trp and its derivatives were also investigated for drug-likeness, and all substances were found to be of a comparable behavior. Precisely an outcome, this compound could be useful in the advancement of therapies.
Implementation of Pancasila Values in Character Education: A Literature Review
Authors: Natalia Veronica Eka Desi , Pratama Anisa OS , Astuti Margareta Dewi 
Published: December 2023

The implementation of Pancasila values in character education is very important and interesting to discuss. There are a number of articles related to the implementation of Pancasila values in character education but there is still little literature on the literature review. The purpose of writing this article is to identify and identify the implementation of Pancasila values in strengthening character education as a literature review. Based on the literature review, it is known that the implementation of Pancasila values is very important in relation to character education. Characters that are appropriate and are shown attitudes related to the values contained in Pancasila, namely the values of character divine values (religious), love for the country, independence, environmental care and tolerance .
Use of daratumumab drug formulation for subcutaneous administration in multiple myeloma therapy: Literature review and clinical observation
Authors: Zeynalova P. A. , Timofeeva O. L. , Ryabukhina Yu. E. , Abbasbeyli F. M. , Kupryshina N. A. , Zhukov A. G. , Valiev T. T. 
Published: December 2023

Study of the molecular pathogenesis of multiple myeloma led to development and introduction of antitumor agents with new mechanisms of action and their combinations into clinical practice. According to several trials, use of anti-CD38 monoclonal antibody daratumumab as part of triplet therapies at an early stage leads to deep and long-term antitumor response, achievement of MRD-negative status, and, as a result, increased survival and improved prognosis in all patient subgroups. High effectiveness of daratumumab subcutaneous formulation close to intravenous formulation has favorable safety profile, short administration time and low rate of infusion reactions which improves patients’ quality of life, affects their treatment compliance, and decreases healthcare costs.We present a clinical observation of a 60-year-old patient with newly diagnosed multiple myeloma who previously underwent treatment for another lymphoproliferative disorder which included autologous hematopoietic stem cell transplantation leading to complete and long-term remission. After 9 intravenous daratumumab infusions (with recommended dose of 16 mg/kg) in accordance to the D-Rd regimen, evaluation of antitumor effect and consideration of socially active lifestyle of the patient, daratumumab formulation for intravenous administration was replaced with subcutaneous formulation of fixed dose 1800 mg. Further deepening of the antitumor response was observed along with manageable safety profile and absence of significant adverse events which allowed to maintain intercourse intervals and improve the patient’s quality of life.