bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELAÇÃO DA SOBRECARGA DE TRABALHO DA EQUIPE DE ENFERMAGEM NA SEGURANÇA DOS PACIENTES
Authors: Campos Bibiana Moreira , Mendes Débora Fernandes , Da Anunciação Gislaine Martins , Cavalcanti Euni de Oliveira 
Published: October 2023

Introdução: A enfermagem desempenha um papel crucial na recuperação e bem-estar dos pacientes, porém, é comum que os profissionais enfrentem uma carga de trabalho excessiva, caracterizada por jornadas extenuantes e escassez de pessoal, o que acarreta em riscos consideráveis para a segurança dos pacientes. Objetivo: Identificar como a sobrecarga de trabalho do enfermeiro afeta a segurança do paciente. Método: Este estudo consiste em uma revisão integrativa da literatura, com ênfase na descrição e uma abordagem qualitativa, a pesquisa dos artigos foi realizada nas bases de dados, LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde), MEDLINE (Sistema Online de Busca e Análise de Literatura Médica), BDENF (Base de Dados de Enfermagem), publicados nos últimos 5 anos. Resultados: Foram encontrados 55 artigos, destes após a análise dos processos de inclusão e exclusão, restaram 17 artigos incluídos na análise. Conclusão: Pesquisas têm indicado que a sobrecarga de trabalho da enfermagem coloca em risco a segurança do paciente, pois, ela está associada a erros de medicação, um aumento nas infecções adquiridas em ambientes de saúde, atrasos na administração de tratamentos, complicações após procedimentos cirúrgicos, retirada não programada de tubos e um incremento nas taxas de mortalidade.
Gnotobiotic pig models: Illuminating the enigma of human norovirus infection and immunity
Authors: Yuan Lijuan 
Published: October 2023

Gnotobiotic pig models: Illuminating the enigma of human norovirus infection and immunity
Dr Lijuan Yuan and her team have studied human noroviruses (HuNoV) in gnotobiotic pigs for over 15 years. Here, she explains how such research is advancing our understanding of HuNoV pathogenesis, infectivity, and immunity. The intricate interplay between pathogens and their hosts has been a focal point of infectious disease research, especially for elusive viruses like human noroviruses (HuNoV). With their capacity to cause acute gastroenteritis and notorious ability to evade traditional cell culture methods, the study of HuNoV has been particularly challenging. However, gnotobiotic pig models have emerged as a potent tool in unveiling the complex dynamics of HuNoV pathogenesis, infectivity, and immunity. This review delves into the application of gnotobiotic pig models in deciphering the enigmatic world of HuNoV, shedding light on their elusive interactions with the host.
Targeting the central nervous system: The future of therapeutic strategies for MS
Authors: DeSilva Tara M 
Published: October 2023

Targeting the central nervous system: The future of therapeutic strategies for MS
Tara M. DeSilva from the Department of Neurosciences, Cleveland Clinic, looks at the future of therapeutic strategies for MS, focusing on targeting the central nervous system. Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease initially characterized by white matter lesions in the central nervous system (i.e., brain, spinal cord, and optic nerve) detected by magnetic resonance imaging (MRI). Lesions are caused by the infiltration of immune cells, resulting in loss of the insulation (myelin) around nerve fibers (neuronal axons). Early in the MS disease course, myelin regenerates; however, over time, sustained demyelination results in axonal injury and permanent disability. (1) The location of a lesion in the brain, spinal cord, or optic nerve determines the type of deficit a patient with MS will experience. Most patients with MS initially present with a relapsing-remitting disease course. During this phase, manifestations of clinical deficits indicate a relapse followed by a recovery or remittance of symptoms. Eventually, MS patients enter into a progressive disease course. During the progressive phase, there is no remittance, and symptoms gradually worsen, leading to permanent disability (Fig. 1).
Bridging the cultural divide in social discourse, Part 5: Practicing intellectual humility in the real world
Authors: Hill Peter C 
Published: October 2023

Bridging the cultural divide in social discourse, Part 5: Practicing intellectual humility in the real world
In this fifth and final article in this series, Peter C. Hill discusses bridging the cultural divide in social discourse, mainly practicing intellectual humility in the real world. People will have differing views on almost anything of interest. So, the critical question is how we view the diversity of opinions and negotiate our differences when they occur. In the first four articles of this five-part series in Open Access Government, I have proposed a concept that has generated considerable research interest in the human sciences called intellectual humility (IH). The focus of this concluding article will be on how IH, as something good for individuals and society, can be put into practice in the real world.
Keep your teeth for life: The tartar challenge
Authors: Christophel Ruth 
Published: October 2023

Keep your teeth for life: The tartar challenge
Dr. Marcel Donnet and Dr. Dixit Neha discuss how GBT can overcome the challenge of tartar removal to preserve your teeth for life. Have you ever looked closely at your teeth in the mirror? When looking carefully, we can sometimes see white or coloured deposits, often around the lower part of the front teeth. These deposits are commonly named as calculus or tartar. What do these deposits indicate? Is it essential to get rid of them? If regular brushing doesn’t do the trick, how can we effectively remove tartar? And, importantly, how can we prevent its build-up in the first place?
CO2 bioeconomy: Creating value from carbon dioxide
Authors: Seng Wong Tuck , Tee Kang Lan 
Published: October 2023

CO2 bioeconomy: Creating value from carbon dioxide
Is the CO2 bioeconomy creating value from carbon dioxide? Dr Kang Lan Tee and Professor Tuck Seng Wong both explain. Carbon dioxide is frequently portrayed as the villain of climate change. A 50% carbon dioxide content increase in less than 200 years (National Oceanic and Atmospheric Administration) is a stark reminder of its role in global warming. Scientists have also linked the rise of carbon dioxide with the greenhouse effect in the past 66 million years (Annual Review of Earth and Planetary Sciences). Beyond scientific reports, we have experienced the heat-dome scorching our summer and witnessed record temperatures in the UK, with the highest temperature recorded at 40.3°C on 19 July 2022. Is carbon dioxide to blame for climate change?
School-to-work transitions for egypt’s youth
Authors: Assaad Ragui 
Published: October 2023

School-to-work transitions for egypt’s youth
Ragui Assaad from Humphrey School of Public Affairs, at the University of Minnesota, argues that structural reforms result in increasingly difficult and unequal school-to-work transitions for Egypt’s youth. Egypt adopted a series of structural reforms since the 1990s designed to curb the size of the public sector and place the economy on a market- oriented trajectory. While these reforms succeeded in shrinking the size of the public workforce from 39% of total employment in 1998 to 26% in 2018, they failed to ignite job creation in the private sector (Ragui Assaad, AlSharawy, and Salemi 2022; Amer, Selwaness, and Zaki 2021). The share of formal private wage employment in total employment increased marginally from 8% in 1998 to 12% in 2018, while overall employment failed to keep up with population growth (Ragui Assaad, AlSharawy, and Salemi 2022).
Glutamate excitotoxicity in the cochlea
Authors: Rutherford Mark A 
Published: October 2023

Glutamate excitotoxicity in the cochlea
Mark Rutherford, Associate Professor at Washington University School of Medicine, discusses the burden and causes of hearing dysfunction, as well as the possible solutions for mitigating glutamate excitotoxicity. The cochlea, the snail-shaped organ of the inner ear located deep in the skull, contains approximately 15,000 sound receptors called sensory ‘hair cells’ and approximately 50,000 nerve fibers sending sound information to the brain. Although that may seem like a lot, it is not compared to the approximately 100 billion neurons in the brain. These hair cells and nerve fibers are all we get for life, and they are gradually lost over time due to aging. Unfortunately, environmental factors accelerate cochlear decline over time. One of those environmental factors is loud sounds.Today, we live in an environment of sound at levels that far exceed those under which our species evolved, especially those of us with noisy occupations or recreational activities. For example, military personnel are particularly vulnerable to hearing loss, making hearing disorders (including tinnitus) the number one disability claim of the U.S. Veterans Administration.
The research experiences for undergraduates (REU) program
Authors: Swain Greg M 
Published: October 2023

The research experiences for undergraduates (REU) program
Greg M. Swain, hailing from the Department of Chemistry at Michigan State University, examines cross-disciplinary training in sustainable chemistry and chemical processes, including the critical role of mentoring and finding research experiences for undergraduates. Sustainability is the practice of reducing the environmental impacts of human existence and conserving natural resources for future generations. Green chemistry is a part of the sustainability approach that encourages manufacturing processes and the design of products that minimize the use and generation of hazardous substances. Stated another way, sustainable chemistry and chemical processes should use resources, including energy and raw materials, “at a rate at which they can be replaced naturally, and the generation” of waste cannot be faster than the rate of their remediation, as Horváth IT points out. (1)
Fathers matter: Supporting new dads during the transition to parenthood
Authors: Costa Deborah Da 
Published: October 2023

Fathers matter: Supporting new dads during the transition to parenthood
Deborah Da Costa, PhD, Associate Professor at the Department of Medicine, McGill University, Scientist at McGill University Health Centre, details promoting and supporting new dads during the transition to parenthood. Approximately one in ten fathers experience mental health difficulties during their partner’s pregnancy and/or the postpartum period. (1-3) Fathers’ mental health difficulties adversely impact parenting, maternal mental health, and couple functioning. A recent systematic review and meta- analysis of 16 observational studies showed that paternal depression was associated with an increased risk of depression in offspring, underscoring the intergenerational transmission of mental health problems. (4) Fathers’ mental health during this life stage is an important public health issue, but it continues to be under-researched, under-recognized, and under-treated.
RNA and DNA flipons in health and disease
Authors: Herbert Alan 
Published: October 2023

RNA and DNA flipons in health and disease
Flipons are the next step in DNA research. What they are, their role in DNA and RNA coding, their impact on medical science, and their relation to the immune system are discussed here. Flipons are DNA and RNA sequences that adopt alternative forms inside our bodies. These different ways of folding nucleic acids were first discovered after Watson and Crick proposed their famous model for DNA called the ‘secret of life’. They were considered mere curiosities until the first crystal structure of DNA revealed that the DNA helix was wound in a left-handed direction rather than the expected right-handed twist of B-DNA.
PREDICTION OF FUNCTIONAL OUTCOMES IN SUPRATENTORIAL INTRACEREBRAL HEMORRHAGE PATIENTS TREATED WITH STEREOTACTIC COMPUTED TOMOGRAPHIC-GUIDED ASPIRATION AND RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR
Authors: Dang Hoai Lan , Nguyen Trong Yen , Vu Van Hoe , Nguyen Thanh Bac 
Published: October 2023

Objectives: To evaluate factors influencing the outcomes in supratentorial intracerebral hemorrhage (ICH) patients treated with stereotactic computed tomographic (CT) guided aspiration and recombinant tissue plasminogen activator (rt-PA). Methods: A prospective study on 80 spontaneous supratentorial ICH cases from February 2017 to June 2020, analyzing the 12-month outcomes and identifying clinical and radiological factors for poor prognosis within 12 months. Results: The mean age was 55.6 years (SD 11.4). The median pre-operation GCS score was 9 (IQR 6 - 12). The mean final ICH volume was 23.9mL (SD 24.6), with ICH volume reduction by an average of 66%. 12 months after the procedure, 40 patients (50%) had poor outcomes (mRS score 4 - 6). In multivariate analysis, age (OR = 1.058, 95%CI = 1.007 - 1.112; p = 0.026), the GCS score before operation (OR = 0.666, 95%CI = 0.448 - 0.992; p = 0.046), the midline shift before operation (OR = 1.301, 95%CI = 1.057 - 1.601; p = 0.013), and the residual volume hematoma ≥ 20mL (OR = 4.402, 95%CI = 1.393 - 13.913, p = 0.012) were the significant predictors of a poor 12-month outcome. Conclusion: CT-guided thrombolysis and aspiration can be safe and effective in reducing ICH volume. Age, the GCS score before the operation, the midline shift before the operation, and final residual volume hematoma ≥ 20mL were significant predictors of a poor 12-month outcome.
Kaempferol Metal Complexes: A Multifaceted Approach to Synthesis, Characterization and Biological Activities
Authors: Syed Sohaila , Jyothi Y.  , Chhetri Deepsika , Lalhriatpuii  , Dhilipan S.  
Published: October 2023

This extensive review explores kaempferol complexes' synthesis, characterization, and biological activities. Kaempferol, a bioactive flavonoid found in plants, exhibits promising therapeutic properties that can be strengthened through complexing using metal ions. The review discusses different metal ions used for complexation and various synthetic approaches. Characterization techniques such as spectroscopy, crystallography, and mass spectrometry are employed to analyze the structure and properties of these complexes. Investigating the biological activities of kaempferol complexes reveals their diverse effects. This review sheds light on their potential for therapeutic interventions and encourages further research in this field by providing valuable insights into the synthesis, characterization, and biological activities of kaempferol complexes.
Future research directions include improving complex stability, enhancing bioavailability, and exploring novel synthesis strategies. Overall, this comprehensive review underscores the importance of unraveling the characterization of kaempferol complexes to harness their full potential in various fields. The knowledge gained from this review can contribute to developing novel therapeutic agents and promote advancements in using kaempferol complexes for improved health outcomes.
Hubungan Pemeriksaan Antenatal Care (ANC) dan Konsumsi Multivitamin Dengan Kejadian Preeklampsia di Wilayah Kerja Puskesmas Latowu
Authors: Handayani Andi , Marfu’ah Siti 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui apakah ada hubungan pemeriksaan ANC dan konsumsi multivitamin dengan kejadian preeklampsia di Puskesmas Latowu. Jenis penelitian menggunakan survei analitik dengan pendekatan cross sectional. Sampel penelitian sebanyak 31 ibu hamil trimester III. Teknik sampling menggunakan Accidental sampling yaitu responden yang kebtulan berada di wilayah kerja puskesmas dengan cara wawancara, pemeriksaan dan screaaning serta menggunakan kuesioner penelitian. Hasil penelitian dari 31 responden diperoleh 12 (85.7%) yang kunjungan ANC nya tidak sesuai standar mengalami preeklampsia. dan yang tidak mengalami preeklampsia adalah responden yang kunjungan ANC nya sesuai standar sebanyak 16 (94.1%). Hasil uji Chi Square diperoleh nilai sig = 0,000 dengan demikian nilai sig 0,000 < 0,05 Sehingga disimpulkan ada hubungan antara kunjungan ANC dengan kejadian preeklampsia di Puskesmas Latowu. Untuk konsumsi multivitamin, sebagian besar responden yang mengalami preeklampsia adalah responden yang konsumsi multivitaminnya tidak teratur sebanyak 12 (80,0%) dan responden yang tidak mengalami preeklampsia adalah responden yang konsumsi multivitaminnya teratur sebanyak 15 (93,8%). Hasil uji Chi Square diperoleh nilai sig = 0,000 dengan demikian nilai sig 0,000 < 0,05. Sehingga disimpulkan ada hubungan antara konsumsi multivitamin dengan kejadian preeklampsia di Puskesmas Latowu.
ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG RĂNG KHÔN HÀM DƯỚI LIÊN QUAN THẦN KINH RĂNG DƯỚI TRONG PHẪU THUẬT CẮT THÂN RĂNG
Authors: Kim Ngọc Khánh Vinh , Trần Thị Phương Đan , Lâm Nhựt Tân 
Published: October 2023

Đặt vấn đề: Tổn thương thần kinh răng dưới là một biến chứng nghiêm trọng trong phẫu thuật nhổ răng khôn hàm dưới. Việc thăm khám và xác định yếu tố nguy cơ chân răng có liên quan thật sự với thần kinh răng dưới là một bước quan trọng trước phẫu thuật. Chụp x quang răng toàn cảnh và chụp cắt lớp điện toán với chùm tia hình nón(Conbeam computed tomography-CBCT) trước phẫu thuật là một việc cần thiết để xác định các dấu hiệu chân răng có liên quan thật sự với thần kinh răng dưới. Mục tiêu nghiên cứu: Mô tả đặc điểm lâm sàng, x quang của răng khôn hàm dưới có liên quan thần kinh răng dưới trên bệnh nhân thực hiện phẫu thuật cắt thân răng khôn hàm dưới. Đối tượng và phương pháp nghiên cứu: 36 bệnh nhân có chỉ định phẫu thuật cắt thân răng được chẩn đoán xác định có răng khôn hàm dưới liên quan thật sự với thần kinh răng dưới. Sử dụng nghiên cứu mô tả cắt ngang. Kết quả: Tỉ lệ bệnh nhân trong độ tuổi từ 18-25(77,8%), tỉ lệ răng khôn loại II(Pell-Gregory) (97,2%) loại A(86,1%), răng khôn nằm ngang và nghiên gần thường gặp nhất (47,2%), dấu hiệu ống thần kinh gián đoạn trên x quang răng toàn cảnh chiếm tỉ lệ cao nhất (44,4%), tỉ lệ chân răng khôn tiếp xúc chạm vỏ ống thần kinh (50%), mất vỏ ống (33,3%) chân răng tiếp xúc ống thần kinh vị trí chóp răng (52,8%). Kết luận: Tỉ lệ chân răng khôn hàm dưới liên quan thật sự với thần kinh răng dưới là khá cao, thường gặp nhất tại vị trí chóp chân răng, dấu hiệu gián đoạn ống thần kinh là phổ biến nhất trên x quang răng toàn cảnh. Việc xác định chính xác mối liên quan giữa chân răng khôn và ống thần kinh là rất quan trọng, từ đó đưa đến việc chỉ định phương pháp phẫu thuật an toàn, hạn chế biến chứng tổn thương thần kinh.
NGHIÊN CỨU TÌNH HÌNH SUY DINH DƯỠNG Ở TRẺ TỪ 24 ĐẾN 59 THÁNG TUỔI TẠI CÁC TRƯỜNG MẦM NON HUYỆN BA TRI, TỈNH BẾN TRE NĂM 2022-2023
Authors: Trịnh Hòa Bình , Lê Thành Tài , Phạm Thị Dương Nhi 
Published: October 2023

Đặt vấn đề: Suy dinh dưỡng đang là vấn đề sức khỏe cộng đồng lớn. Hậu quả là tình trạng phát triển kém về thể chất và trí tuệ và để lại hậu quả lâu dài khi trưởng thành. Theo Tổ chức Y tế Thế giới (WHO), đến năm 2020, thế giới sẽ có khoảng 149 triệu trẻ em dưới 5 tuổi. Mục tiêu nghiên cứu: Xác định tỷ lệ và mức độ suy dinh dưỡng của trẻ từ 24-59 tháng tuổi và một số yếu tố liên quan đến tình trạng suy dinh dưỡng tại các trường mầm non huyện Ba Tri, Tỉnh Bến Tre năm 2022-2023. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang trên 1036 trẻ từ 24 -59 tháng tuổi tại các trường mầm non trên địa bàn huyện Ba Tri, tỉnh Bến Tre năm 2022-2023. Kết quả: Tỷ lệ SDD thể nhẹ cân là 2,5%, SDD thể thấp còi là 7,0%, SDD gầy còm là 1,5% và tỷ SDD chung là 8,6%. Một số yếu tố liên quan tìm thấy là kiến thức, thực hành lựa chọn nguồn thức ăn đạm, tinh bột, rau củ, thói quen tẩy giun định kỳ cho trẻ (p<0,05). Kết luận: Cần có những biện pháp nâng cao kiến thức và cải thiện thực hành cho các bà mẹ góp phần giảm tỷ lệ suy dinh dưỡng ở trẻ 24 - 59 tháng tuổi.
Evaluation of effectiveness of transcranial mesodiencephalic modulation within comprehensive treatment of pulmonary tuberculosis patients with various comorbidities
Authors: Serov O. A. , Smolentseva O. A. 
Published: October 2023

The objective: to study the impact of transcranial mesodiencephalic modulation on eff ectiveness of comprehensive treatment of pulmonary tuberculosis patients with various comorbidities.Subjects and Methods. 48 patients who received standard regimens of anti-tuberculosis chemotherapy participated in the study; the patients were divided into two groups. In Group 1, patients additionally underwent sessions of mesodiencephalic modulation (MDM), while in Group 2, no MDM was administered.Results. Two months after the start of the study, in Group 1, positive radiological changes were recorded more often – in 91,7% (22/24), in Group 2, positive changes were observed in 62,5% (15/24) of patients (p=0,047; χ2); the same pattern was observed with positive changes of laboratory rates – 91,7% (22/24) versus 66,7% (16/24), (p=0,033; χ2), respectively. In patients of Group 1 compared to Group 2, symptoms of tuberculosis and comorbid conditions fully disappeared or became less intensive in 79,2% (19/24) versus 41,7% (10/24), (p=0,009; χ2). In Group 1, adverse drug reactions were registered in 16,7% (4/24), in Group 2 – 43,5% (10/24), (p=0,05; χ2).
A specific course of tuberculous spondylitis with concurrent HIV infection
Authors: Rakhmatillaev Sh. N. , Gavrilov P. V. , Tursunova N. V. , Chernov S. S. , Stavitskaya N. V. 
Published: October 2023

The article describes a clinical case of surgical treatment of tuberculous spondylitis and tuberculous pleurisy in a HIV positive patient with disseminated pulmonary tuberculosis. A severe pain syndrome in tuberculous spondylitis was the fi rst clinical manifestation of generalized multiple drug resistant tuberculosis.Surgical treatment of spinal deformity relieved the pain syndrome, microbiological results of surgical biopsy of the vertebrae and pleura allowed prescribing the eff ective treatment for generalized tuberculosis
Contracturas musculares en la Gimnasia Aeróbica Deportiva en el contexto de la Educación Física universitaria de Cuba
Authors: García Valdés Solanch de la Caridad , Abreu Anisleidy , Vásquez Luisa 
Published: October 2023

La Educación Física en Cuba se reconoce como un derecho de todos y para todos. En ella se realizan actividades desde la clase tradicional hasta los programas competitivos y recreativos que se desarrollan en horarios docentes, extra docentes y fines de semana. La Gimnasia Aeróbica Deportiva forma parte de estos programas competitivos de la Educación Física alcanzando una significativa masividad en todos los niveles de enseñanza desde la primaria hasta las universidades. Teniendo en cuenta las características de esta modalidad deportiva la aparición de lesiones se muestra como una problemática recurrente en los practicantes sistemáticos de la misma.En el presente artículo utilizamos un enfoque cualitativo no experimental con métodos teóricos y empíricos, los cuales permiten arribar a conclusiones y posicionamientos. Los resultados obtenidos permitieron la incorporación de estos ejercicios a las clases de Gimnasia Aeróbica Deportiva en el contexto de la Educación Física universitaria de la Universidad de Ciencias de la Cultura Física y el Deporte Manuel Fajardo.
En él presentamos una propuesta de ejercicios para la prevención de las contracturas musculares en la Gimnasia Aeróbica Deportiva de dicha universidad.Estos ejercicios pueden llevar a resultados positivos en la práctica de la Gimnasia Aeróbica Deportiva en la Educación Física, incluyendo una mayor motivación para participar en este deporte dentro y fuera del entorno escolar.