bluuebunny/crossref_metadata_2025_split huggingface dataset:
(086) Retrospective Concomitant Nonrandomized Comparison of Testosterone Replacement Therapy versus No Treatment for Erectile Function Post Radical Prostatectomy
Authors: Hammad MAM , Gevorkyan R , Tran J , Fung C , Barham DW , Ahlering T , Yafi FA 
Published: February 2024

Abstract

Introduction
Recent studies have shown that testosterone replacement therapy (TRT) can be safely applied in men with low-risk prostate cancer.

Objective
To assess TRT versus no TRT 2-year potency outcomes in hypogonadal men aged ≥ 60.

Methods
Retrospective concomitant nonrandomized comparison of 70 hypogonadal men, aged 60 or older, were stratified by TRT post-RP. Baseline demographics, total testosterone (TT) calculated free testosterone (cFT), and comorbidities prior to RP were measured from October 2016 – October 2020. Sexual function was assessed via the International Index of Erectile Function (IIEF-5) pre-and post-surgery. Potency (evaluated at 3-, 9-, 15-, and 24-months post-RP) was defined as erections sufficient for penetration and satisfying, and/or erection fullness &gt;75%, and/or a score of 5 on Q1 (IIEF-5; confidence). T-tests, chi-square, and regression analyses were performed.

Results
Potency at 2 years was 63.6% (TRT) versus 35.1% (No TRT; p=0.017). Regression analysis showed that TRT was a predictor of potency outcomes 2 years post-RP (OR: 3.33; 95% CI: 1.16-10.3; p=0.029) after adjusting for age and Gleason Grade Group. There were no statistically significant differences in baseline factors between the TRT-receiving and no-TRT groups. BCR rates between the two groups were 12.1% (TRT) versus 27.0% (no TRT; p=0.12) with a mean follow-up time of 40.2 ± 13.6 months. Kaplan Meier analysis demonstrated a trend toward a significant difference in time to BCR (p=0.078).

Conclusions
In hypogonadal men aged ≥ 60, TRT significantly improved potency outcomes 2-years post-RP. The risk of BCR overall in men receiving TRT was lower but not statistically significant.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Faysal A Yafi, MD – Advisory board and speaker for Coloplast; consultant for Cynosure; advisory board and speaker for Halozyme; intellectual property with Masimo; advisory board for Promescent; consultant for Sprout; advisory board for Xialla.
(103) Predictors of Sexual Arousal in Women: A Secondary Data Analysis
Authors: Hitt M , Teater A 
Published: February 2024

Abstract

Introduction
Low sexual desire and lack of arousal are highly prevalent sexual problems in women. Despite high prevalence, sexual arousal difficulties have not been a priority focus of assessment and treatment of women at midlife. Relationship satisfaction and importance of sex are key to healthy sexual function at midlife. Psychosocial variables, including relationship satisfaction, communication with one’s partner, and importance of sex are associated with overall sexual satisfaction. Rosemary Basson’s intimacy-based model of female sexual response incorporates the need for intimacy and emotional satisfaction and acknowledges the impact of sexual arousal on responsive sexual desire and physical satisfaction. Better understanding of the impacts of emotional satisfaction in female sexual response and function is needed to direct improvements in assessment and treatment of sexual problems in midlife women.

Objective
To explore the associations of emotional satisfaction, sexual desire, importance of sex and ability to climax with frequency of arousal during sexual activity in menopausal women.

Methods
A secondary data analysis of the Study of Women’s Health Across the Nation (SWAN), USA, 2006-2008 (Visit 10) dataset was completed utilizing multiple linear regression to assess variables associated with frequency of sexual arousal in menopausal women. A total of 2,245 women between the ages of 51-63 years were included. The mean age was 56 years.

Results
Multiple linear regression results demonstrated that 19% of the variability in frequency of arousal in our study population was explained by emotional satisfaction (F (1,1163) = 271.039, p&lt;.001). Further analyses revealed that 56% of the variability in frequency of arousal was explained by emotional satisfaction, sexual desire, importance of sex, and ability to climax (F (6,1014) = 215.461, p&lt;.001).

Conclusions
Interventions designed to enhance emotional satisfaction with a partner may positively impact female sexual arousal. Emotional satisfaction with a partner is strongly associated with frequency of sexual arousal in menopausal women. Additionally, sexual desire, importance of sex and ability to climax are also strongly associated with frequency of sexual arousal. These findings are clinically relevant and reinforce the need for biopsychosocial assessment of sexuality and sexual function, as well as thorough assessment of dyadic and interpersonal factors. Further research is needed to better understand the impacts and interplay of psychosocial variables on female sexual response and function.

Disclosure
No.
(110) Socioeconomic Factors Impacting Density of Certified Sex Therapists in the United States
Authors: Leelani N , Shumaker A , Lanpher NW , Bole R , Asif A , Khooblall P , Parekh N , Lundy SD , Bajic P 
Published: February 2024

Abstract

Introduction
An exploratory study mapping sex therapists based on the top ten Google results in each state concluded that most sex therapists were located in larger metropolitan areas, and importantly, they found that only 18.2% of clinicians offering sex therapy services were certified by a national organization such as AASECT.

Objective
To map where certified sex therapists practice and what variables influence where they practice in the United States.

Methods
The American Association of Sexuality Educators, Counselors, and Therapists online directory was queried for certified sex therapists in each state. Univariable and multiple linear regression analyses were utilized to assess the relationship between the density of certified sex therapists in each state with various training and socioeconomic factors.

Results
Across all 50 states and the District of Columbia the median density of sex therapists per 500,000 people was 1.28 (IQR 0.82, 1.83). On univariable linear regression, median household income (p &lt; .01, R2 = .20), percent of state population with a bachelor’s degree or higher (p &lt; .01, R2 = .57), and percent of state population living in an urban setting (p &lt; .01, R2 = .18) were significantly correlated with the density of certified sex therapists in each state. On multiple linear regression, percent of state population with a bachelor’s degree or higher (p &lt; .01) and percent of population not in poverty (p &lt; .01) remained significantly correlated with the density of certified sex therapists in each state.

Conclusions
Certified sex therapists are more likely to practice in urban settings with populations that have a higher median income and are more educated.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Boston Scientific, Coloplast.
(137) Sealed Vasectomy Procedure Prior Studies and Now Good Laboratory Practices FDA Study: Human, Porcine, Canine and Rabbit Subjects
Authors: Henry G , Hakky T , Pannell W , Nighan W , Jones L 
Published: February 2024

Abstract

Introduction
The Sealed Vasectomy Procedure (SVP) is a new bipolar radiofrequency sealing tool for transdermal vasectomy in hopes of making the procedure a faster, simpler, and safer office procedure. Testing has been successful in rabbits with excellent wound healing, complete vas occlusion on histology, and no sperm in post procedural semen analysis. Further studies in larger animals were then done in canine, porcine and human vas deferens that showed good sealing of the vas deferens. FDA-approval are needed before its application in humans. The next step in FDA approval process is a FDA prescribed Good Laboratory Practices (GLP) animal study.

Objective
Evaluate the effectiveness of the SVP in sealing the vas deferens in rabbit, canine, porcine and in humans. Now presenting the FDA prescribed GLP study.

Methods
Rabbit studies have been previously described including AUA22 best video award. We preformed microscopic evaluation of the vas deferens tissues from canines treated with the SVP at either 40 or 60 watts, euthanized at 14 days post-treatment under the conditions of this study. Human vas deferens specimens after removal from the patient were then immediately treated with SVP tool on benchtop. Porcine vas deferens samples were procured and underwent benchtop testing. The GLP study was done at Charles River in Kalamazoo, Michigan. The GLP study was on 6 canines: 3 with the outside the skin method and 3 canines with the transdermal method. All were terminal after a period of healing of up to 28 days.

Results
9 canine, 6 human, and 20 porcine vas deferens were included in SVP testing. Human, porcine, and canine specimens demonstrated tissue coagulation and fibrosis in the treated vasa deferentia by Pathology. (See Figure 1 Human and 2 Canine) For the FDA GLP prescribed study, all 6 dogs survived and were euthanized at 28 days post-treatment. Pathology for the GLP study was done by Charles River.

Conclusions
SVP is a potentially exciting novel vasectomy procedure that appears to provide good sealing of the vas deferens in the rabbit & canine animal model and on benchtop for the human & porcine vas deferens. The FDA GLP study is done and awaits FDA submission. FDA-approval is still needed before use in humans.

Disclosure
Yes, this is sponsored by industry/sponsor: Signati.
Clarification: Industry initiated, executed and funded study.
Any of the authors act as a consultant, employee or shareholder of an industry for: Signati.
(203) Awareness of Monkeypox Virus Among International Urology Faculty and Trainees is Low: Implications for Early Recognition and Diagnosis
Authors: Hammad M , Miller J , Amini E , Fattash A , Yazar R , Nguyen J , Azad B , Yafi F 
Published: February 2024

Abstract

Introduction
The recent international outbreak of Monkeypox virus (Mpox), has raised concerns regarding the recognition and management of this disease among healthcare professionals. The genitourinary presentation of Mpox as variable cutaneous lesions poses a unique challenge for Urologists in its prevention, diagnosis, and management.

Objective
To assess the understanding and recognition of Mpox among international urologists and urology trainees.

Methods
A survey relating to the presentation, transmission, and management of Mpox was distributed to urologists and urology trainees during the joint 23rd Sexual Medicine Society of North America (SMSNA)/ 23rd International Society for Sexual Medicine (ISSM) conference.

Results
Out of 960 attendees, 97 (10.1%) responded to the survey. The rate of respondents who correctly identified a Mpox lesion from a series of cutaneous lesions was 25.8%. A similarly low number of respondents were able to identify the likelihood of having anogenital lesions and oral bleeding on presentation with Mpox at 15.5% and 19.6% respectively. A higher number of respondents accurately noted that diagnosis of Mpox may be made with PCR (79.4%) and that men with multiple male sexual partners are at the highest risk of transmission (72.2%) (Table 1).

Conclusions
When surveyed regarding the presentation, transmission, and management of Mpox, urologists and urology trainees were generally unable to accurately identify Mpox from a series of cutaneous lesions or the rate at which Mpox may present with anogenital lesions. The limited recognition of its presentation, appropriate diagnostic methods, and distinguishing features from sexually transmitted lesions raises concerns about potential missed diagnoses and delayed treatment. Continued education within the urology community may be necessary for the appropriate detection of and intervention against Mpox.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, Antares Pharma, Clarus Therapeutics.
Multiomics analyses reveal the central role of the nucleolus and its machinery during heat stress acclimation in Pinus radiata
Authors: Escandón Mónica , Valledor Luis , Lamelas Laura , Álvarez Jóse M , Cañal María Jesús , Meijón Mónica 
Published: February 2024

Abstract
Global warming is causing rapid changes in mean annual temperature and more severe drought periods. These are major contributors of forest dieback, which is becoming more frequent and widespread. In this work, we investigated how the transcriptome of Pinus radiata changed during initial heat stress response and acclimation. To this end, we generated a high-density dataset employing Illumina technology. This approach allowed us to reconstruct a needle transcriptome, defining 12 164 and 13 590 transcripts as down- and up-regulated, respectively, during a time course stress acclimation experiment. Additionally, the combination of transcriptome data with other available omics layers allowed us to determine the complex inter-related processes involved in the heat stress response from the molecular to the physiological level. Nucleolus and nucleoid activities seem to be a central core in the acclimating process, producing specific RNA isoforms and other essential elements for anterograde–retrograde stress signaling such as NAC proteins (Pra_vml_051671_1 and Pra_vml_055001_5) or helicase RVB. These mechanisms are connected by elements already known in heat stress response (redox, heat-shock proteins, or abscisic acid-related) and with others whose involvement is not so well defined such as shikimate-related, brassinosteriods, or proline proteases together with their potential regulatory elements. This work provides a first in-depth overview about molecular mechanisms underlying the heat stress response and acclimation in P. radiata.
The cysteine-rich receptor-like kinase CRK10 targeted by Coniella diplodiella effector CdE1 contributes to white rot resistance in grapevine
Authors: Liu Ruitao , Tan Xibei , Wang Yiming , Lin Feng , Li Peng , Rahman Faiz Ur , Sun Lei , Jiang Jianfu , Fan Xiucai , Liu Chonghuai , Zhang Ying 
Published: February 2024

Abstract
Grape white rot is a devastating fungal disease caused by Coniella diplodiella. The pathogen delivers effectors into the host cell that target crucial immune components to facilitate its infection. Here, we examined a secreted effector of C. diplodiella, known as CdE1, which has been found to inhibit Bax-triggered cell death in Nicotiana benthamiana plants. The expression of CdE1 was induced at 12–48 h after inoculation with C. diplodiella, and the transient overexpression of CdE1 led to increased susceptibility of grapevine to the fungus. Subsequent experiments revealed an interaction between CdE1 and Vitis davidii cysteine-rich receptor-like kinase 10 (VdCRK10) and suppression of VdCRK10-mediated immunity against C. diplodiella, partially by decreasing the accumulation of VdCRK10 protein. Furthermore, our investigation revealed that CRK10 expression was significantly higher and was up-regulated in the resistant wild grapevine V. davidii during C. diplodiella infection. The activity of the VdCRK10 promoter is induced by C. diplodiella and is higher than that of Vitis vitifera VvCRK10, indicating the involvement of transcriptional regulation in CRK10 gene expression. Taken together, our results highlight the potential of VdCRK10 as a resistant gene for enhancing white rot resistance in grapevine.
H ii regions and diffuse ionized gas in the AMUSING++ Compilation – I. Catalogue presentation
Authors: Lugo-Aranda A Z , Sánchez S F , Barrera-Ballesteros J K , López-Cobá C , Espinosa-Ponce C , Galbany L , Anderson Joseph P 
Published: February 2024

ABSTRACT
We present a catalogue of ∼52 000 extragalactic H ii regions and their spectroscopic properties obtained using Integral Field Spectroscopy (IFS) from MUSE observations. The sample analysed in this study contains 678 galaxies within the nearby Universe (0.004 &lt;z &lt; 0.06) covering different morphological types and a wide range of stellar masses (6 &lt; log(M*/M⊙) &lt; 13). Each galaxy was analysed using the pipe3d and pyhiiextractor codes to obtain information of the ionized gas and underlying stellar populations. Specifically, the fluxes, equivalent widths, velocities and velocity dispersions of 30 emission lines covering the wavelength range between λ4750 to λ9300 Å, were extracted and were used to estimate luminosity weighted ages and metallicities of the underlying stellar populations from each H ii region (of the original sample we detect H ii regions in 539 galaxies). In addition, we introduce and apply a novel method and independent of any intrinsic physical property to estimate and decontaminate the contribution of the diffuse ionized gas. Using the final catalogue, we explore the dependence of properties of the H ii regions on different local and global galaxy parameters: (i) Hubble type, (ii) stellar mass, (iii) galactocentric distance, and (iv) the age and metallicity of the underlying/neighbour stellar populations. We confirm known relations between properties of the H ii regions and the underlying stellar populations (in particular, with the age) uncovered using data of lower spatial and spectral resolution. Furthermore, we describe the existence of two main families of diffuse ionized gas different for galaxies host or not of H ii regions.
A uniform analysis of debris discs with the Gemini Planet Imager II: constraints on dust density distribution using empirically informed scattering phase functions
Authors: Hom Justin , Patience J , Chen C H , Duchêne G , Mazoyer J , Millar-Blanchaer M A , Esposito T M , Kalas P , Crotts K A , Gonzales E C , Kolokolova L , Lewis B L , Matthews B C , Rice M , Weinberger A J , Wilner D J , Wolff S G , Bruzzone S , Choquet E , Debes J , De Rosa R J , Donaldson J , Draper Z , Fitzgerald M P , Hines D C , Hinkley S , Hughes A M , López R A , Marchis F , Metchev S , Moro-Martin A , Nesvold E , Nielsen E L , Oppenheimer R , Padgett D , Perrin M D , Pueyo L , Rantakyrö F , Ren B B , Schneider G , Soummer R , Song I , Stark C C 
Published: February 2024

ABSTRACT
Spatially resolved images of debris discs are necessary to determine disc morphological properties and the scattering phase function (SPF) thatantifies the brightness of scattered light as a function of phase angle. Current high-contrast imaging instruments have successfully resolved several dozens of debris discs around other stars, but few studies have investigated trends in the scattered-light, resolved population of debris discs in a uniform and consistent manner. We have combined Karhunen-Loeve Image Projection (KLIP) with radiative-transfer disc forward modelling in order to obtain the highest-quality image reductions and constrain disc morphological properties of eight debris discs imaged by the Gemini Planet Imager at H-band with a consistent and uniformly applied approach. In describing the scattering properties of our models, we assume a common SPF informed from solar system dust scattering measurements and apply it to all systems. We identify a diverse range of dust density properties among the sample, including critical radius, radial width, and vertical width. We also identify radially narrow and vertically extended discs that may have resulted from substellar companion perturbations, along with a tentative positive trend in disc eccentricity with relative disc width. We also find that using a common SPF can achieve reasonable model fits for discs that are axisymmetric and asymmetric when fitting models to each side of the disc independently, suggesting that scattering behaviour from debris discs may be similar to Solar system dust.
Weak gravitational lensing measurements of Abell 2744 using JWST and shear measurement algorithm pyRRG-JWST
Authors: Harvey David R , Massey Richard 
Published: February 2024

ABSTRACT
We update the publicly available weak lensing shear measurement algorithm pyRRG for the JWST, and apply it to UNCOVER DR1 imaging of galaxy cluster Abell 2744. At short wavelengths (${\lt}2.5\, \mu$m), shear measurements are consistent between independent observations through different JWST bandpasses, and calibrated within 1.5 per cent of those from the Hubble Space Telescope. At longer wavelengths, shear is underestimated by ∼5 per cent, probably due to coarser pixellization. We model the spatially varying point spread function using WebbPSF, whose moments are within 0.05 of real stars near the centre of the mosaic, where there are sufficient stars to also generate an empirical model. We measure shear from up to 162 galaxies arcmin−2 to derive a map of dark plus baryonic mass with 12 arcsec (55 kpc) spatial resolution. All code, catalogues, and maps are available from https://github.com/davidharvey1986/pyRRG.
Neutron star mergers and their impact on second generation star formation in the early universe
Authors: Skinner Danielle , Wise John H 
Published: February 2024

ABSTRACT
The exact evolution of elements in the Universe, from primordial to heavier elements produced via the r-process, is still under scrutiny. The supernova deaths of the very first stars led to the enrichment of their local environments, and can leave behind neutron stars (NSs) as remnants. These remnants can end up in binary systems with other NSs, and eventually merge, allowing for the r-process to occur. We study the scenario where a single NS merger (NSM) enriches a halo early in its evolution to understand the impact on the second generation of stars and their metal abundances. We perform a suite of high-resolution cosmological zoom-in simulations using enzo where we have implemented a new NSM model varying the explosion energy and the delay time. In general, an NSM leads to significant r-process enhancement in the second generation of stars in a galaxy with a stellar mass of ∼105 M⊙ at redshift 10. A high explosion energy leads to a Population II (Pop II) mass fraction of 72 per cent being highly enhanced with r-process elements, while a lower explosion energy leads to 80 per cent being enhanced, but only 14 per cent being highly enhanced. When the NSM has a short delay time of 10 Myr, only 5 per cent of the mass fraction of Pop II stars is highly enhanced, while 64 per cent is highly enhanced for the longest delay time of 100 Myr. This work represents a stepping stone towards understanding how NSMs impact their environments and the metal abundances of descendant generations of stars.
The rise and fall of dust in the Universe
Authors: Eales Stephen , Ward Bradley 
Published: February 2024

ABSTRACT
We estimate how the mean density of dust in the Universe varies with redshift, using submillimetre continuum observations and a method designed to minimize the effect of dust temperature. We have used the Herschel Astrophysical Terahertz Large Area Survey (Herschel-ATLAS) to show that the median temperature of dust in galaxies is $\simeq 22\ \mathrm{ K}$ and does not vary significantly with redshift out to z = 1. With this as our estimate of the mass-weighted dust temperature, we have used an 850-μm survey of the field of the Cosmological Evolution Survey (COSMOS) to estimate the mean density of dust in 10 redshift bins over the range 0 &lt; z &lt; 5.5. We find that the mean density of dust increased by a factor of ≃10 from z = 5 to z = 2, declined slightly to z = 1, and then steeply to the present day. The relationship between the mean density of dust and redshift is similar to the relationship between the mean star formation rate and redshift, although the increase for the former is steeper from z = 5 to z = 2. We have also used the submillimetre measurements to estimate the mean density of gas over the same redshift range. The values we estimate for the dust-traced gas are much lower and with a different redshift dependence than those for estimates of the mean density of atomic gas but similar to those for estimates of the mean density of the CO-traced gas. We find that the depletion time for the dust-traced gas in the Universe as a whole declines with redshift in the same way as seen for individual galaxies.