bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leptin as a predictive marker for lymph node metastasis in patients with papillary thyroid cancer
Authors: Abdelrahim Hossam S. , Mohamed Mohamed A. , Elshafei Mahmoud A. , Farahat Mahmoud S. , Goda Mohammed H. 
Published: January 2024

Background
Leptin is a neuroendocrine hormone produced from adipose tissue with many vital functions. There is a well-known association between leptin and papillary thyroid cancer (PTC). Preoperative prediction of lymph node metastasis is one of the interesting topics in PTC. This study aimed to determine whether the serum leptin peptide is a significant predictor marker for node metastasis in cases with PTC.

Patients and methods
This is a prospective comparative study which was conducted at Ain Shams University Hospitals and El-Sheikh Zayed specialized hospital between January 2021 and January 2023. Forty patients with PTC were enrolled in this study and according to postoperative histopathology, we divided them into two groups: group A, 24 cases, those with pathological negative node and group B, 16 cases, those with pathological positive node.

Results
We had no statistically significant difference in the preoperative demographics data between both groups. Postoperatively, the median serum leptin level and percentage of leptin decrease were significantly higher in in group B. Multivariate logistic regression analysis showed that preoperative serum leptin level, thyroid imaging reporting and data system, multifocality, extra thyroid extension, and size of dominant nodule were significant predictors for node metastasis. There was a significant negative correlation between leptin level and age, while there was a significant positive correlation between leptin level and lymph node metastasis.

Conclusion
Preoperative serum leptin level is considered a significant predictor marker for lymph node metastasis in PTC.
Laparoscopic value in the management of acute abdomen during pregnancy
Authors: Ahmed Emad A. , Helmy Mena Z. , Taha Ahmed A.-R. A. , Saleem Abd-El-Aal A. 
Published: January 2024

Background
Acute abdominal pain during pregnancy represents a challenging pathology in diagnosis and treatment. This study aimed to evaluate the value of laparoscopy in managing pregnant patients presented with acute abdomen.

Materials and methods
From June 2022 to June 2023, 45 pregnant females presented with acute abdominal pain were prospectively analyzed. These patients were treated laparoscopically, aiming for diagnostic and treatment purposes. Intra- and Postoperative evaluations for the laparoscopic value were assessed for all possible complications early, during the hospital stay and until the first postoperative 30 days.

Results
Inflammation 82.2%, including acute appendicitis 89.7%, and cholecystitis 10.3%, were found to be the most common causes of acute abdomen. No intraoperative or postoperative morbidity, including infection, sepsis, or wound dehiscence, was reported until the first 30 days. Similarly, no postoperative mortality was detected. Moreover, no cases had abortions during their conception time.

Conclusion
Laparoscopic value exceeds the treatment advantages but has a significant role in diagnosing the etiologies of acute abdomen during pregnancy. Laparoscopy could successfully treat different pathologies during pregnancy. No restriction for the time of conception regarding the use of laparoscopy was reported. Further comparative studies regarding laparoscopic use during pregnancy should be conducted.
Outcome of dufourmentel flap versus conventional rhomboid (Limberg flap) in the treatment of complex pilonidal sinus: a randomized controlled study
Authors: Abdelrahman Emad M. , Kilany Elsayed O. , Shoulah Ahmed A. , Ghazy Amal H. , Elgazzar Sherif A. 
Published: January 2024

Background
Management of pilonidal disease lacks a single optimal treatment strategy, and recurrence is a problem for both the patient and the surgeon. Various flap-based treatment approaches are available for the treatment of such problems. This study aims to compare the outcome of dufourmentel flap versus conventional rhomboid in complex pilonidal diseases.

Patients and methods
The present randomized controlled study included 64 patients with complex pilonidal sinus, who were randomly divided into two groups: group A (n=32) patients underwent a dufourmentel flap while group B (n=32) patients underwent conventional rhomboid (Limberg flap). Follow-up was planned for early postoperative complications and recurrence as well as the aesthetic outcome.

Results
The mean age was 25.3±7.4 and 25.8±5.8.years in groups A and B, respectively. There was a statistically significant longer flap in group A when compared with group B (P=0.04). The mean operative time was 39.3±4.8 and 43±4.4 in groups A and B, respectively. Postoperative follow-up revealed a higher rate of complications in group B than in group A with a statistically significant difference in postoperative infection/discharge, hematoma, seroma, and partial flap loss.

Conclusion
Due to its adaptability, repeatability, clear, and predictable closure of the defect, and low recurrence rate, the authors suggest the dufourmentel flap as a suitable approach in the treatment of difficult and recurrent cases.
Outcomes of continous versus interrupted suturing techniques for biliary-enteric anastomosis after choledochal cyst excision in children
Authors: Sabra Tarek Abdelazeem , Abdelmohsen Sarah Magdy , Maher Ahmed , Abdelgawaad Moamen Shalkamy , Mohamed Abdelhalem Showkat , Mohammed Haitham Mohammed Ahmad , Badawy Amr 
Published: January 2024

Background
In this study, the biliary-enteric anastomosis following choledochal cyst excision was studied using continuous suture and interrupted suture procedures in a pediatric population.

Patients and methods
In this study, information on 57 children who received continuous suture choledochal cyst surgery at our facility between 2015 and 2020 was gathered retrospectively. The patients that were enrolled were divided into two groups: continuous suture (n=24) and interrupted suture (n=33).
Anastomotic leakage, anastomotic duration in minutes, hospital stay in days, and cost were all compared between these groups.

Results
The incidence of anastomotic leakage was higher in the interrupted suture group (4.17 vs. 6.6% for continuous suture and interrupted suture, respectively), but the difference was statistically insignificant (P=0.63). The groups did not differ regarding hospital stays (P=0.25). The mean time required to complete the anastomosis in the continuous suture group was 15.3±4.1 min, compared with 23.5±5.2 min in the interrupted suture group (P<0.0001). The costs were &z.euro;5±0.0 in the continuous suture group and &z.euro;30±6.4 in the interrupted suture group (P<0.0001).

Conclusion
The anastomotic leakage and hospital stay did not differ between the continuous suture and interrupted suture groups. In contrast, the continuous suture group had a considerable advantage over the interrupted suture group in terms of anastomotic duration and cost.
Efficacy of local metronidazole with glyceryl trinitrate versus topical glyceryl trinitrate alone in the treatment of acute anal fissure: a randomized clinical trial
Authors: Elgendy Hesham M. , AbdelMawla Ahmed , Hussein Ahmed F. 
Published: January 2024

IntroductionAnal fissure is one of the most common diseases of the anorectal region that is frequently encountered in surgical practice, equally affects both women and men. Acute anal fissures last shorter than 6 weeks. The American Society of Colon and Rectal Surgeons favors conservative management of anal fissure as the first line of treatment. A rectal ointment containing 0.2% glyceryl triturate (GTN) can be recommended to promote the healing of anal fissures and decreasing sphincter spasm. Metronidazole is a 5-nitroimidazole derivative antibiotic with a cytotoxic bactericidal effect particularly on anaerobic bacteria.The purpose of the present study was to investigate whether local metronidazole antibiotic cream is effective and safe to use in reducing the symptoms and improving the healing process of acute anal fissure.Patients and methodsThis study was performed in Mansoura University Hospital, surgery outpatient clinic from the period of July 2022 till July 2023. This study was a single-blinded, randomized controlled trial.Total 100 patients were included in this study and randomly divided into two groups, 50 patients in each group. First group (group 1) treated by combination of local metronidazole 10% with 0.2% GTN while the second group treated only with GTN.ResultsAnal pain were present in both group in all patients with acute anal fissure while constipation were 88% in group 1 and 76% group 2. To lesser extent itching, bleeding, and diarrhea were presented in both group.Visual analog scale for pain intensity were equal in both groups at the time of first clinical examination. After 1 week and 1 month of treatment there were statistically significant difference between both groups thus the visual analog scale were lower in group 1 than group 2 (0.001 and <0.001, respectively).Healing of acute anal fissure was assessed clinically at variable interval for all patients there is statistically significant difference between both group (0.004) as regard healing, first group showed earlier and faster healing and fewer number of nonhealing of the fissure at the end of follow up.ConclusionAdding local metronidazole 10% to the classic GTN treatment will improve the symptoms of acute anal fissure specially pain and discomfort and markedly accelerate healing process.
First Molecular Identification of Rickettsia aeschlimannii and Rickettsia africae in Ticks from Ghana
Authors: Tagoe Janice A. , Addo Seth O. , Mosore Mba-tihssommah , Bentil Ronald E. , Agbodzi Bright , Behene Eric , Ladzekpo Danielle , Addae Charlotte A. , Nimo-Painstil Shirley , Fox Anne T. , Bimi Langbong , Dafeamekpor Courage , Richards Allen L. , Letizia Andrew G. , Diclaro Joseph W. , Dadzie Samuel K. 
Published: January 2024

ABSTRACT.
The threats from vector-borne pathogens transmitted by ticks place people (including deployed troops) at increased risk for infection, frequently contributing to undifferentiated febrile illness syndromes. Wild and domesticated animals are critical to the transmission cycle of many tick-borne diseases. Livestock can be infected by ticks, and serve as hosts to tick-borne diseases such as rickettsiosis. Thus, it is necessary to identify the tick species and determine their potential to transmit pathogens. A total of 1,493 adult ticks from three genera—Amblyomma, Hyalomma, and Rhipicephalus—were identified using available morphological keys and were pooled (n = 541) by sex and species. Rickettsia species were detected in 308 of 541 (56.9%) pools by genus-specific quantitative polymerase chain reaction assay (Rick17b). Furthermore, sequencing of the outer membrane protein A and B genes (ompA and ompB) of random samples of Rickettsia-positive samples led to the identification of Rickettsia aeschlimannii and Rickettsia africae with most R. africae DNA (80.2%) detected in pools of Amblyomma variegatum. We report the first molecular detection and identification of the rickettsial pathogens R. africae and R. aeschlimannii in ticks from Ghana. Our findings suggest there is a need to use control measures to prevent infections from occurring among human populations in endemic areas in Ghana. This study underscores the importance of determining which vector-borne pathogens are in circulation in Ghana. Further clinical and prevalence studies are needed to understand more comprehensively the clinical impact of these rickettsial pathogens contributing to human disease and morbidity in Ghana.
Clinical Laboratory Investigations and Antivenom Administration after Malayan Pit Viper (Calloselasma rhodostoma) Envenoming: A Retrospective Study from Southernmost Thailand
Authors: Chesor Musleeha , Chaisakul Janeyuth , Promsorn Panuwat , Chantkran Wittawat 
Published: January 2024

ABSTRACT.
The Malayan pit viper (MPV: Calloselasma rhodostoma) is a medically important venomous snake causing numerous envenomations in Thailand. Administration of specific snake antivenom is the only effective treatment for MPV-envenomed patients. However, inappropriate administration or misuse of snake antivenom is problematic in some remote areas of tropical countries where the snakebite envenoming rate is notable. Currently, the indications for administration of MPV antivenom are focused mainly on hematological factors. These include 1) venous clotting time > 20 min, 2) unclotted 20-minute whole-blood clotting time, 3) international normalized ratio > 1.2, 4) platelet count < 50 × 103/μL, 5) systemic bleeding, and 6) impending compartment syndrome. We aimed to determine the association between laboratory data and antivenom administration in MPV-envenomed patients. A retrospective study of data from 2016 to 2021 in Narathiwat Province, the southernmost province in Thailand, was conducted. A total of 838 MPV-bitten patients were included in this study. Local effects and systemic effects were observed in 58.8% and 27.7% of patients, respectively. Coagulopathies, which range from abnormal blood clotting to systemic bleeding, represented the majority of systemic effects. Acute kidney injury developed in 2.5% of patients. In this study, 57.3% of patients were considered appropriate antivenom recipients. Interestingly, the present study revealed that local bleeding and mild to moderate thrombocytopenia became the independent factors for inappropriate use of MPV antivenom. Reeducation and supervision regarding the rational use of snake antivenom are needed to minimize the misuse of antivenom.
The Predictive Ability of Communicative Competence of Peer Acceptance among the Twelfth-grade Students in the State of Kuwait
Authors: Alhabashi Reem Abdulmohsen , Mattar Jehan Wadiea 
Published: January 2024

This study aimed to identify the level of communicative competence and peer acceptance, and the relationship between the communicative competence and peer acceptance, and whether there were differences in the relationship between the variables attributed to sex between the twelfth-grade students amounted to (25215) students for the academic year 2020/2021. The sample of the study consisted of (608) males and female's students. They were selected through the convenience sampling method. The correlational descriptive methodology was applied in this study. Two tools were also used commensurate with the study and its objectives. Tools were the communicative competence and peer acceptance scale. Results showed that the level of communicative competence was high with a mean of (3.83), and the level of peer acceptance was also high with a mean of (4.18), Results also showed that there was a statistically significance positive relationship at the significance level (0.05) between communicative competence and peer acceptance, where the value of correlation coefficient was (0.61). The results also showed that the communicative competence has explained (37%) of the variation in peer acceptance as predicted by peer acceptance, and there were statistically significant differences at the level of (0.05) in the relationship between the communicative competence and peer acceptance in favor of males.
Teaching Quality and its Relationship with Achievement Motivation of Tenth Grade Students in Kuwait State
Authors: Mubarak Maryam Mubarak J. , Mattar Jehan Wadiea 
Published: January 2024

The current study aimed to identify the level of teaching quality and the achievement motivation among tenth grade students in Kuwait and the relationship between them. The sample was formed of (956) students, containing (395) male students and (561) female students of the secondary school’ tenth grade in Kuwait. Their ages range from (15-16) years old. Two tools were used: the three-dimensional teaching quality scale (Classroom Management, Cognitive Activation, Support), and achievement motivation scale. The results indicated that both teaching quality and achievement motivation had high levels. The results also indicated that there was a statistically significant positive correlation at level of significance (0.05) between the total score of teaching quality and achievement motivation amounted to (0.444). Moreover, the results concluded that there were no statistically significant differences at the significance level (0.05) in the relationship between teaching quality and achievement motivation attributed to the variable of gender.
Finally, this study recommended that further studies concerning teaching quality and achievement motivation should be conducted on various age groups.
Ajeg Bali dan Modal Sosial: Studi Sosiologi terhadap Perubahan Sosial Masyarakat Bali
Authors: Prayitno Ujianto Singgih 
Published: January 2024

This research is motivated by the problems faced by the people of Bali who have traditional values that typical and relatively different than any other community in Indonesia. Disclosure Bali as one of the domestic and international tourism destination, considered by many potentially threaten the existence of the traditional values. One form of reaction that occurs is the social movement “Ajeg Bali” which requires the robustness of the values of Bali. While the social change is a necessity. Social change can take place in a positive, supported by social capital and indigenous communities, or on the contrary it weakens the local wisdom. Through a qualitative descriptive approach, it looks the Balinese community resistance to social change caused by the development of tourism, through movement of Ajeg Bali and rejection of Benoa Bay reclamation. However, there are also activities that are actually supported by the Tri Hita Karana local wisdom which comes from Hinduism to survive and thrive, such as Subak irrigation and development of Institute of Rural Creditors that prop up the economy. Penelitian ini dilatarbelakangi oleh adanya permasalahan yang dihadapi oleh masyarakat Bali yang memiliki nilai tradisional yang khas dan relatif berbeda dibandingkan masyarakat lain di wilayah Indonesia. Keterbukaan Bali sebagai salah satu tujuan pariwisata domestik dan internasional, dinilai oleh banyak pihak mengancam keberadaan nilai tradisional tersebut. Salah satu bentuk reaksi yang muncul adalah adanya gerakan sosial “Ajeg Bali” yang menghendaki kekokohan nilai-nilai Bali. Sementara perubahan sosial merupakan keniscayaan. Perubahan sosial dapat berlangsung secara positif yang didukung oleh modal sosial dan kearifan lokal masyarakat, ataupun sebaliknya justru memperlemah kearifan lokal setempat. Melalui pendekatan deskriptif kualitatif, terlihat adanya perlawanan masyarakat Bali terhadap perubahan sosial yang diakibatkan oleh pembangunan pariwisata, melalui gerakan Ajeg Bali dan penolakan terhadap reklamasi teluk Benoa. Meskipun demikian, terdapat pula kegiatan yang justru didukung oleh kearifan lokal Tri Hita Karana yang bersumber dari Agama Hindu dapat bertahan dan berkembang, seperti pengairan Subak dan berkembangnya Lembaga Perkreditan Rakyat yang menopang perekonomian
Faktor Psikososial dalam Interaksi Masyarakat dengan Gerakan LGBT di Indonesia
Authors: Andina Elga 
Published: January 2024

In this paper we elaborate the psychosocial factors that affecting Indonesian community in dealing with LGBT movement. There has been an increase of LGBT campaign in the beginning of 2016 where they’re demanding protection from discimination, violence, and constitutional barriers. However, LGBT is still considered deviation to local wisdom, making it abnormality according to American Psychiatry Association (APA)’s guidance. LGBT movement is in contrast with most people’s belief, healthy behavioral patterns, and positive children’s developmental phase. Parents are worry that their kids will engage in sexual disorder. Childhood is the most important phase to prepare for functional adulthood. Thus, government is clear when saying there’s no room for LGBT movement. Even so, as a citizen, LGBT people are the subject that must abide and be protected by the law. Therefore, government must implement the law precisely without exception to make sure everyone’s safe. At the same time, government need to deliver more education and socialization to increase respecting behavior among citizens. Dalam tulisan ini kami mengelaborasi faktor-faktor psikososial yang memengaruhi komunitas Indonesia ketika berhadapan dengan gerakan LGBT. Terjadi peningkatan kampanye LGBT pada awal 2016 dimana mereka menuntut perlindungan dari diskriminasi, kekerasan, dan hambatan konstitusional untuk melakukan perkawinan sesama jenis. Akan tetapi, LGBT dianggap bertentangan dengan kearifan lokal, sehingga dapat disebut abnormalitas sesuai dengan petunjuk American Psychiatry Association (APA). Gerakan LGBT bertentangan dengan keyakinan kebanyakan orang, pola-pola perilaku sehat, dan tahap perkembangan anak yang positif. Orang tua khawatir jika anaknya melakukan perilaku seksual yang menyimpang. Masa kanak-kanak merupakan fase yang paling penting untuk mempersiapkan pada masa dewasa yang fungsional. Selain itu, Pemerintah juga sudah jelas menyatakan bahwa tidak memberikan ruang bagi gerakan LGBT. Akan tetapi, sebagai warga negara pelaku LGBT harus tunduk dan dilindungi peraturan yang ada. Oleh karena itu, pemerintah perlu mengimplementasikan hukum secara tepat dan tanpa pengecualian untuk memastikan semua orang terlindungi. Bersamaan dengan itu, pemerintah juga melakukan edukasi dan sosialisasi untuk meningkatkan perilaku saling menghormati sesama warga negara.