bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease
Authors: Xicota Laura , Cosentino Stephanie , Vardarajan Badri , Mayeux Richard , Perls Thomas T. , Andersen Stacy L. , Zmuda Joseph M. , Thyagarajan Bharat , Yashin Anatoli , Wojczynski Mary K. , Krinsky‐McHale Sharon , Handen Benjamin L. , Christian Bradley T. , Head Elizabeth , Mapstone Mark E. , Schupf Nicole , Lee Joseph H. , Barral Sandra ,   the Long‐Life Family Study (LLFS),   Alzheimer's Disease Genetic Consortium (ADGC)
Published: February 2024

AbstractINTRODUCTIONLate‐onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long‐Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics.METHODSWe conducted a whole genome sequence analysis of 3475 LLFS members. Genetic associations were examined in six independent studies (N = 14,260) with a wide range of LOAD risk. Association analysis in a sub‐sample of the LLFS cohort (N = 1739) evaluated the association of LOAD variants with beta amyloid (Aβ) levels.RESULTSWe identified several single nucleotide polymorphisms (SNPs) in tight linkage disequilibrium within the MTUS2 gene associated with LOAD (rs73154407, p = 7.6 × 10−9). Association of MTUS2 variants with LOAD was observed in the five independent studies and was significantly stronger within high levels of Aβ42/40 ratio compared to lower amyloid.DISCUSSIONMTUS2 encodes a microtubule associated protein implicated in the development and function of the nervous system, making it a plausible candidate to investigate LOAD biology.Highlights
Long‐Life Family Study (LLFS) families may harbor late onset Alzheimer's dementia (LOAD) variants.
LLFS whole genome sequence analysis identified MTUS2 gene variants associated with LOAD.
The observed LLFS variants generalized to cohorts with wide range of LOAD risk.
The association of MTUS2 with LOAD was stronger within high levels of beta amyloid.
Our results provide evidence for MTUS2 gene as a novel LOAD candidate locus.
Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage
Authors: Joseph‐Mathurin Nelly , Feldman Rebecca L. , Lu Ruijin , Shirzadi Zahra , Toomer Carmen , Saint Clair Junie R. , Ma Yinjiao , McKay Nicole S. , Strain Jeremy F. , Kilgore Collin , Friedrichsen Karl A. , Chen Charles D. , Gordon Brian A. , Chen Gengsheng , Hornbeck Russ C. , Massoumzadeh Parinaz , McCullough Austin A. , Wang Qing , Li Yan , Wang Guoqiao , Keefe Sarah J. , Schultz Stephanie A. , Cruchaga Carlos , Preboske Gregory M. , Jack Clifford R. , Llibre‐Guerra Jorge J. , Allegri Ricardo F. , Ances Beau M. , Berman Sarah B. , Brooks William S. , Cash David M. , Day Gregory S. , Fox Nick C. , Fulham Michael , Ghetti Bernardino , Johnson Keith A. , Jucker Mathias , Klunk William E. , la Fougère Christian , Levin Johannes , Niimi Yoshiki , Oh Hwamee , Perrin Richard J. , Reischl Gerald , Ringman John M. , Saykin Andrew J. , Schofield Peter R. , Su Yi , Supnet‐Bell Charlene , Vöglein Jonathan , Yakushev Igor , Brickman Adam M. , Morris John C. , McDade Eric , Xiong Chengjie , Bateman Randall J. , Chhatwal Jasmeer P. , Benzinger Tammie L. S. ,   for the Dominantly Inherited Alzheimer Network
Published: February 2024

AbstractINTRODUCTIONAmyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin‐1 (PSEN1) mutation carriers. We investigated how mutation position relative to codon 200 (pre‐/postcodon 200) influences these pathologic features and dementia at different stages.METHODSIndividuals from families with known PSEN1 mutations (n = 393) underwent neuroimaging and clinical assessments. We cross‐sectionally evaluated regional Pittsburgh compound B‐positron emission tomography uptake, magnetic resonance imaging markers of SVD (diffusion tensor imaging‐based white matter injury, white matter hyperintensity volumes, and microhemorrhages), and cognition.RESULTSPostcodon 200 carriers had lower amyloid burden in all regions but worse markers of SVD and worse Clinical Dementia Rating® scores compared to precodon 200 carriers as a function of estimated years to symptom onset. Markers of SVD partially mediated the mutation position effects on clinical measures.DISCUSSIONWe demonstrated the genotypic variability behind spatiotemporal amyloidosis, SVD, and clinical presentation in DIAD, which may inform patient prognosis and clinical trials.Highlights
Mutation position influences Aβ burden, SVD, and dementia.
PSEN1 pre‐200 group had stronger associations between Aβ burden and disease stage.
PSEN1 post‐200 group had stronger associations between SVD markers and disease stage.
PSEN1 post‐200 group had worse dementia score than pre‐200 in late disease stage.
Diffusion tensor imaging‐based SVD markers mediated mutation position effects on dementia in the late stage.
Post‐intensive care syndrome: Recent advances and future directions
Authors: Inoue Shigeaki , Nakanishi Nobuto , Amaya Fumimasa , Fujinami Yoshihisa , Hatakeyama Junji , Hifumi Toru , Iida Yuki , Kawakami Daisuke , Kawai Yusuke , Kondo Yutaka , Liu Keibun , Nakamura Kensuke , Nishida Takeshi , Sumita Hidenori , Taito Shunsuke , Takaki Shunsuke , Tsuboi Norihiko , Unoki Takeshi , Yoshino Yasuyo , Nishida Osamu 
Published: February 2024

AbstractPost‐intensive care syndrome comprises physical, cognitive, and mental impairments in patients treated in an intensive care unit (ICU). It occurs either during the ICU stay or following ICU discharge and is related to the patients' long‐term prognosis. The same concept also applies to pediatric patients, and it can greatly affect the mental status of family members. In the 10 years since post‐intensive care syndrome was first proposed, research has greatly expanded. Here, we summarize the recent evidence on post‐intensive care syndrome regarding its pathophysiology, epidemiology, assessment, risk factors, prevention, and treatments. We highlight new topics, future directions, and strategies to overcome post‐intensive care syndrome among people treated in an ICU. Clinical and basic research are still needed to elucidate the mechanistic insights and to discover therapeutic targets and new interventions for post‐intensive care syndrome.
Efficacy of Endovascular Thrombectomy in Acute Basilar Artery Occlusion with Low PC‐ASPECTS: A Nationwide Prospective Registry‐Based Study
Authors: Chang Jun Young , Lee Ji Sung , Kim Wook‐Joo , Kwon Jee Hyun , Kim Beom Joon , Kim Joon‐Tae , Lee Jun , Cha Jae Kwan , Kim Dae‐Hyun , Cho Yong‐Jin , Hong Keun‐Sik , Lee Soo Joo , Park Jong‐Moo , Kang Kyusik , Lee Byung‐Chul , Yu Kyung‐Ho , Lee Sang‐Hwa , Kim Chulho , Park Kwang‐Yeol , Kim Dong‐Eog , Lee Kyungbok , Park Tai Hwan , Choi Jay Chol , Shin Dong‐Ick , Sohn Sung‐Il , Bae Hee‐Joon , Han Moon‐Ku ,   the CRCS‐K‐NIH (Clinical Research Collaboration for Stroke in Korea‐National Institutes of Health) investigators
Published: February 2024

ObjectiveWe evaluated the efficacy of endovascular thrombectomy (EVT) on the functional outcome of patients with acute basilar artery occlusion and low posterior circulation acute stroke prognosis early computed tomography score (PC‐ASPECTS).MethodsWe identified patients with acute ischemic stroke due to basilar artery occlusion and PC‐ASPECTS of 6 or less, presenting within 24 h between August 2008 and April 2022. The primary outcome was a favorable functional outcome, defined as a modified Rankin Scale (mRS) score of 0–3 at 90 days. The secondary outcomes included an mRS score of 0–2, a favorable shift in the ordinal mRS scale, the occurrence of symptomatic intracranial hemorrhage (sICH), and mortality at 90 days. We compared the outcome of patients treated with EVT and those without EVT, using the inverse probability of treatment weighting methods.ResultsOut of 566 patients, 55.5% received EVT. In the EVT group, 106 (33.8%) achieved favorable outcomes, compared to 56 patients (22.2%) in the conservative group. EVT significantly increased the likelihood of achieving a favorable outcome compared to conservative treatment (relative risk [RR] 1.39, 95% confidence interval [CI], 1.11–1.74, p = 0.004). EVT was associated with a favorable shift in the mRS (RR 1.85, 95% CI, 1.49–2.29, p < 0.001) and reduced mortality without an increase in the risk of sICH. It did not have an impact on achieving an mRS score of 0–2.InterpretationPatients with acute basilar artery occlusion and a PC‐ASPECTS of 6 or less might benefit from EVT without an increasing sICH. ANN NEUROL 2024;95:788–799
Preparation and properties of transparent, waterproof, and antibacterial composite film materials
Authors: Wang Haihua , Zhang Hao , Yang Chenrong , Fei Guiqiang , Xie Pan 
Published: February 2024

AbstractTransparent polymer materials, such as plastics, have become widely used in the packaging industry due to their excellent properties. However, their nondegradability has led to a significant environmental issue known as “white pollution.” To address this issue, a transparent antibacterial film material was prepared using carboxymethyl cellulose and carboxymethyl chitosan as raw materials through an acid‐assisted freeze–thaw strategy. The material exhibits optical transmittance exceeding 90% and a tensile strength of up to 124.1 MPa. Meanwhile, this material demonstrated excellent waterproof performance as well as antibacterial activity to Staphylococcus aureus and Escherichia coli. Therefore, this film material holds promising potential for development in antibacterial food packaging.
Metatarsals and foot phalanges from the Sima de los Huesos Middle Pleistocene site (Atapuerca, Burgos, Spain)
Authors: Pablos Adrián , Arsuaga Juan Luis 
Published: February 2024

AbstractThis study provides a complete, updated and illustrated inventory, as well as a comprehensive study, of the metatarsals and foot phalanges (forefoot) recovered from the Middle Pleistocene site of Sima de los Huesos (SH, Atapuerca, Spain) in comparison to other Homo comparative samples, both extant and fossils. This current updated review has established a minimum number of individuals (MNI) of 17, which represent 58.6% of the 29 dental individuals identified within the SH sample. An exclusive or autoapomorphic combination of traits can be recognized within the SH hominin foot sample. A few traits appear primitive or plesiomorphic when compared with earlier Homo individuals and other recent modern humans. There are other metrical and morphological traits that SH hominins and Neandertals have in common that sometimes represent shared derived traits in this evolutionary line, most of which are probably related to robusticity. Furthermore, some exclusive autoapomorphic traits are observed in the SH sample: a very broad first metatarsal, long and broad hallucal proximal foot phalanges and possibly extremely robust lateral distal foot phalanges compared to those of Neandertals and modern humans. In these last traits, the SH metatarsals and pedal phalanges are even more robust than in Neandertals. They are herein named as “hyper‐Neandertal” traits, which could suggest a slight gracilization process in this evolutionary line, at least in the hallux toe. Finally, some paleobiological inferences are made in relation to body size (stature and body mass) and some associations are proposed within the SH sample.
Alkoxylated Fluoranthene‐Fused [3.3.3]Propellanes: Facile Film Formation against High π‐Core Content
Authors: Kato Kenichi , Uchida Yuta , Kaneda Tomoya , Tachibana Tomoki , Ohtani Shunsuke , Ogoshi Tomoki 
Published: February 2024

AbstractSolid‐state assembling modes are as crucial as the chemical structures of single molecules for real applications. In this work, solid‐state structures and phase‐transition temperatures are investigated for a series of fluoranthene‐fused [3.3.3]propellanes consisting of a rigid three‐dimensional (3D) π‐core and varying lengths of alkoxy groups. Compounds in this series with n‐butoxy or longer alkoxy groups take an amorphous state at room temperature. In these molecules, rotatable biaryl‐type bonds are not incorporated and high D3h molecular symmetry is retained. Therefore, π‐fused [3.3.3]propellanes present a unique platform for amorphous molecular materials with low ratios of flexible alkoxy atoms to rigid π‐core ones.
Modeling chloramine stability and disinfection byproduct formation in groundwater high in bromide
Authors: Shimabuku Kyle , Henrie Tarrah , Schultise David , Pillai Sunil 
Published: February 2024

AbstractBromide can promote monochloramine decomposition and disinfection byproduct (DBP) formation. Monochloramine and total chlorine stability as well as total trihalomethane and haloacetic acid formation were examined in groundwater with high bromide levels (300–1700 μg/L) following chlorine or KMnO₄ preoxidation. An N,N‐Diethyl‐p‐phenylenediamine (DPD)‐based total chlorine method detected chloramines and brominated amines (e.g., NH2Br, NHBrCl). An indophenol‐based monochloramine method showed minimal interference from brominated amines. Differences between these methods' measurements likely indicated brominated amine concentrations. Substantial total chlorine demands (up to ~3.5 mg/L in 4 days) following chlorine preoxidation were observed due to the presence of brominated amines. Total chlorine measurements were more stable and DBP formation was limited following KMnO₄ preoxidation because ammonia was dosed before chlorine, which inhibited brominated amine formation. A kinetic model developed elsewhere for dissolved organic matter (DOM)‐free water generally tracked with experimental results but some deviations occurred possibly because DOM consumed bromochloramine or its reaction intermediates.
Chromatographic authentication of botanical origin: Herbaceous pollen profiling with HPLC, HPTLC and GC–MS analysis
Authors: Aziza Nozimova , Khaydarov Khislat , Zafar Muhammad , Alsakkaf Waleed A. A. , Alkahtani Jawaher , Ahmad Mushtaq , Makhkamov Trobjon , Djumayeva Zamira , Zengin Gokhan , Eshboyevich Tursunboev Khamdam , Beilerli Aferin , Gareev Ilgiz , Ochilov Ulugbek , Sultanovich Islamov Boston , Iskandarovna Umurzakova Zebiniso , Wibawa I Putu Agus Hendra 
Published: February 2024

AbstractThis study describes a robust chromatographic authentication methodology for herbaceous pollen, employing gas chromatography–mass spectrometry (GC–MS), high‐performance liquid chromatography (HPLC) and high‐performance thin liquid chromatography (HPTLC) protocols. The comprehensive profiling of organic compounds not only distinguishes between different botanical sources but also establishes a reliable framework for quality control and assessment of herbaceous pollen authenticity. Traces of quercetin were detectable using HPTLC in Chaenomeles japonica, and the composition of the mobile phase led to distinct phenolic acid tracks in the extracts of free phenolic compounds. In Lonicera nummulariifolia, prominent chlorogenic acid signal and traces of 3,4‐dihydroxybenzoic acid were identified, along with the presence of vanillic, trans‐ferulic, p‐coumaric and p‐hydroxybenzoic and sinapic as phenolic acid standards. The HPLC chromatogram identified six peaks representing bioactive phenolic compounds such as gallic acid measuring 5.89 ± 0.56 mg g−1, hydroxybenzoic acid 2.39 ± 0.78 mg g−1 and caffeic acid 2.83 ± 0.11 mg g−1. The combined use of GC–MS, HPTLC and HPLC techniques provides a powerful and reliable means of authenticating the botanical origin of herbaceous pollen, offering valuable insights for quality control and ensuring the accuracy of botanical source identification.
Scrotal nodular scabies
Authors: Sang Bo , Liu Zehu , Xia Xiujiao 
Published: February 2024

Key Clinical MessageScabies is a highly infectious parasitic skin disease, The most common lesions are solid and 2–3 mm in diameter (papules). Very few cases will develop into nodular scabies, and microscopy is frequently negative in patients with clinically diagnosed nodular scabies. The accuracy of microscopy depends on the expertise of the operator, particularly in finding burrows and extracting the relevant material.
Cooperative Covalent–Noncovalent Organocatalysis of the Knoevenagel Condensation Based on an Amine and Iodonium Salt Mixture
Authors: Sysoeva Alexandra A. , Il'in Mikhail V. , Bolotin Dmitrii S. 
Published: February 2024

AbstractThe experimentally obtained kinetic data has indicated the existence of a synergetic cocatalytic effect provided by an iodonium salt in the base‐catalyzed Knoevenagel condensation. The diphenyliodonium triflate serving as the halogen bond‐donating Lewis acid provides the higher cocatalytic effect than zinc(II) triflate or triflic acid serving, respectively, as the metal cation‐based Lewis acid and Brønsted acid. Such a cocatalytic effect remains the same for a broad scope of carbonyl compounds covering aldehydes featuring electron‐withdrawing or electron‐donating substituents, as well as ketone involved in the reaction.
Hybrid hard carbon framework derived from polystyrene bearing distinct molecular crosslinking for enhanced sodium storage
Authors: Qiu Yuqian , Jiang Guangshen , Su Yanxia , Zhang Xinren , Du Yuxuan , Xu Xiaosa , Ye Qian , Zhang Jinbo , Ban Miaohan , Xu Fei , Wang Hongqiang 
Published: February 2024

AbstractExploiting high‐performance yet low‐cost hard carbon anodes is crucial to advancing the state‐of‐the‐art sodium‐ion batteries. However, the achievement of superior initial Coulombic efficiency (ICE) and high Na‐storage capacity via low‐temperature carbonization remains challenging due to the presence of tremendous defects with few closed pores. Here, a facile hybrid carbon framework design is proposed from the polystyrene precursor bearing distinct molecular bridges at a low pyrolysis temperature of 800°C via in situ fusion and embedding strategy. This is realized by integrating triazine‐ and carbonyl‐crosslinked polystyrene nanospheres during carbonization. The triazine crosslinking allows in situ fusion of spheres into layered carbon with low defects and abundant closed pores, which serves as a matrix for embedding the well‐retained carbon spheres with nanopores/defects derived from carbonyl crosslinking. Therefore, the hybrid hard carbon with intimate interface showcases synergistic Na ions storage behavior, showing an ICE of 70.2%, a high capacity of 279.3 mAh g−1, and long‐term 500 cycles, superior to carbons from the respective precursor and other reported carbons fabricated under the low carbonization temperature. The present protocol opens new avenues toward low‐cost hard carbon anode materials for high‐performance sodium‐ion batteries.
Recycled graphite for more sustainable lithium‐ion batteries
Authors: Olutogun Mayokun , Vanderbruggen Anna , Frey Christoph , Rudolph Martin , Bresser Dominic , Passerini Stefano 
Published: February 2024

AbstractThe demand for lithium‐ion batteries (LIBs) is driven largely by their use in electric vehicles, which is projected to increase dramatically in the future. This great success, however, urgently calls for the efficient recycling of LIBs at the end of their life. Herein, we describe a froth flotation‐based process to recycle graphite—the predominant active material for the negative electrode—from spent LIBs and investigate its reuse in newly assembled LIBs. It has been found that the structure and morphology of the recycled graphite are essentially unchanged compared to pristine commercial anode‐grade graphite, and despite some minor impurities from the recycling process, the recycled graphite provides a remarkable reversible specific capacity of more than 350 mAh g−1. Even more importantly, newly assembled graphite‖NMC532 cells show excellent cycling stability with a capacity retention of 80% after 1000 cycles, that is, comparable to the performance of reference full cells comprising pristine commercial graphite.
One–Step Hydrothermal Synthesis of NVO Cathodes with Varied Lattice NH4+ Content: Effect on Structural Evolution and Electrochemical Performance
Authors: Jiang Yanchen , Wang Chao , Huang Jiangfeng , Huang Yin , Sun Ao , Li Xia , Lu Jiayi , Wen Zuoliang , Xue Liang , Zhu Junwu 
Published: February 2024

AbstractAqueous zinc ion batteries have been extensively researched due to their distinctive advantages such as low cost and high safety. Vanadium oxides are important cathode materials, however, poor cycle life caused by vanadium dissolution limits their application. Recent studies show that the lattice NH4+ in vanadium oxides can act as a pillar to enhance structural stability and play a crucial role in improving its cycling stability. Nevertheless, there is still a lack of research on the effect of the lattice NH4+ content on structural evolution and electrochemical performance. Herein, we synthesize vanadium oxides with different contents of lattice NH4+ by a one‐step hydrothermal reaction. The vanadium oxides with lattice NH4+ exhibit high initial capacity, as well as good cycling stability and rate performance compared to bare vanadium oxide. Combined with electrochemical analyses, ex‐situ structural characterizations, and in‐situ X‐ray diffraction tests, we reveal that the lattice NH4+ content plays a positive role in vanadium oxides′ structural stability and cation diffusion kinetics. This work presents a direction for designing high–performance vanadium cathodes for aqueous zinc ion batteries.
Constructing Hollow Microcubes SnS2 as Negative Electrode for Sodium‐ion and Potassium‐ion Batteries
Authors: Li Chengping , Yu Hongrui , Dong Peng , Wang Ding , Zeng Xiaoyuan , Wang Jinsong , Zhang Zhengfu , Zhang Yingjie , Sarapulova Angelina , Luo Xianlin , Pfeifer Kristina , Ehrenberg Helmut , Dsoke Sonia 
Published: February 2024

AbstractSodium/potassium‐ion batteries (NIBs and KIBs) are considered the most promising candidates for lithium‐ion batteries in energy storage fields. Tin sulfide (SnS2) is regarded as an attractive negative candidate for NIBs and KIBs thanks to its superior power density, high‐rate performance and natural richness. Nevertheless, the slow dynamics, the enormous volume change and the decomposition of polysulfide intermediates limit its practical application. Herein, microcubes SnS2 were prepared through sacrificial MnCO3 template‐assisted and a facile solvothermal reaction strategy and their performance was investigated in Na and K‐based cells. The unique hollow cubic structure and well‐confined SnS2 nanosheets play an important role in Na+/K+ rapid kinetic and alleviating volume change. The effect of the carbon additives (Super P/C65) on the electrochemical properties were investigated thoroughly. The in operando and ex‐situ characterization provide a piece of direct evidence to clarify the storage mechanism of such conversion‐alloying type negative electrode materials.
Exploring Spin‐Orbit Effects in a [Cu6Tl]+ Nanocluster Featuring an Uncommon Tl−H Interaction
Authors: Hertler Phoebe R. , Yu Xiaojuan , Brower Jordan D. , Nguyen Thuy‐Ai D. , Wu Guang , Autschbach Jochen , Hayton Trevor W. 
Published: February 2024

AbstractReaction of [CuH(PPh3)]6 with 1 equiv. of Tl(OTf) results in formation of [Cu6TlH6(PPh3)6][OTf] ([1]OTf]), which can be isolated in good yields. Variable‐temperature 1H NMR spectroscopy, in combination with density functional theory (DFT) calculations, confirms the presence of a rare Tl−H orbital interaction. According to DFT, the 1H chemical shift of the Tl‐adjacent hydride ligands of [1]+ includes 7.7 ppm of deshielding due to spin‐orbit effects from the heavy Tl atom. This study provides valuable new insights into a rare class of metal hydrides, given that [1][OTf] is only the third isolable species reported to contain a Tl−H interaction.