bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Political Force of Memory: The Making and Unmaking of Brexit as an Event
Authors: Krawatzek Félix , Pestel Friedemann 
Published: October 2023

AbstractWhat qualifies as a political event is a core question for social and historical research. This article argues that the use of temporal structures in narratives of political and social developments contributes significantly to the making and unmaking of events. We show how arguments that draw upon history play a particularly important role in transforming the everyday unfolding of politics into discernable events with a clear time bracket. Through this lens, we investigate the 2016 Brexit referendum as an event that has triggered extensive debates about both Europe’s experiences of the past and political expectations for its future. Conflicting assessments of history are crucial for understanding how and when Brexit became an event of European significance and why it then ceased to be so. This case also enables us to distinguish more clearly between the agent-centered focus on the event itself, and the analytical ex-post assessment as a critical juncture. Methodologically, the article demonstrates the value of a multi-perspective approach for qualitative analyses with a focus on Brexit narratives articulated across several EU countries and the United Kingdom.
Capital Structure with Information about the Upside and the Downside
Authors: Chaigneau Pierre 
Published: October 2023

AbstractI introduce two dimensions of uncertainty, about the upside and the downside of an asset, in a model of asset valuation under asymmetric information. This justifies capital structures with equity and risky debt for information revelation purposes. However, a capital structure with only one information-sensitive security, equity, can be optimal when investors are less informed about the dimension that matters more for valuation. This is relevant for innovative firms with a large upside subject to strong information asymmetries, which often have abnormally low leverage, and for firms at an intermediate stage of their life cycle that do not issue risky debt.
Kinematic modeling and hybrid motion planning for wheeled-legged rovers to traverse challenging terrains
Authors: Zhu Bike , He Jun , Sun Jiaze 
Published: October 2023

AbstractThis paper presents a kinematics modeling and hybrid motion planning framework for wheeled-legged rovers. It is a unified solution for wheeled-legged rovers to traverse multiple challenging terrains using hybrid locomotion. A kinematic model is first established to describe the rover’s motions. Then, a hybrid motion planning framework is proposed to determine the rover’s gait patterns and parameterize the legs’ and the body’s trajectories. Furthermore, an optimization algorithm based on B-spline is utilized to minimize the motors’ energy dissipation and generate smooth trajectories. The wheeled and legged hybridization allows the rover for faster locomotion while maintaining high stability. Besides, it also improves the rover’s ability to overcome obstacles. Prototype experiments are carried out in more complex environments to verify the rover’s flexibility and maneuverability to traverse irregular terrains. The proposed algorithm reduces the swing amplitude by 83.3% compared to purely legged locomotion.
Anomalous hepatic drainage and platypnea-orthodeoxia in cyanotic children
Authors: Bichali Saïd , Soquet Jérôme , Bouzguenda Ivan , Lérisson Héloïse , Ung Alexandre , Pontana François , Godart François , Le Duc Kévin , Nuytten Alexandra , Houeijeh Ali 
Published: October 2023

AbstractThe aetiology of cyanosis could be unclear in children, even for specialised paediatricians. Two cases were reported: first, a 6-year-old child with features of left isomerism and Fallot was fortuitously diagnosed with anomalous hepatic venous drainage before complete repair. Second, a newborn with an antenatal diagnosis of ductus venosus agenesis had an isolated intermittent right-to-left atrial shunt when upright, with favourable outcome, in contrast to the association with significant heart malformations including inferior caval vein interruption. Multimodality imaging and 3D printing helped to rule out extracardiac causes of persistent cyanosis and plan surgical repair.
High‐Resolution Large‐Eddy Simulations of Flow in the Complex Terrain of the Canadian Rockies
Authors: Rohanizadegan Mina , Petrone Richard M. , Pomeroy John W. , Kosovic Branko , Muñoz‐Esparza Domingo , Helgason Warren D. 
Published: October 2023

AbstractImproving the calculation of land‐atmosphere fluxes of heat and water vapor in mountain terrain requires better resolution of thermally driven diurnal winds (i.e., valley, slope winds) due to differential heating by terrain and radiative fluxes. In this study, the Weather Research and Forecasting model is used to simulate flow in large‐eddy simulation (LES) mode over the complex terrain of the Fortress Mountain and Marmot Creek research basins, Kananaskis Valley, Canadian Rockies, Alberta in mid‐summer. The model was used to examine the temporal and spatial evolution of local winds and near‐surface boundary layer processes with variability in topography and elevation. Numerically resolving complex terrain wind flow effects require smaller grid cell size. However, the use of terrain‐following coordinates in most numerical weather prediction models results in large numerical errors when flow over steep terrain is simulated. These errors propagate through the domain and can result in numerical instability. To avoid this issue when simulating flow over steep terrain a local smoothing approach was used, where smoothing is applied only where slope exceeds some predetermined threshold. LES results from local smoothing were compared with a mesoscale model and LES with global smoothing. Simulations are evaluated using sounding data and meteorological stations. The differences in flow patterns and reversals in two mountain basins suggest that valley geometry and volume is relevant to the break up of inversion layers, removal of cold‐air pools, and strength of thermally driven winds.
Snow‐Atmosphere Humidity Exchange at the Ice Sheet Surface Alters Annual Mean Climate Signals in Ice Core Records
Authors: Dietrich Laura J. , Steen‐Larsen Hans Christian , Wahl Sonja , Jones Tyler R. , Town Michael S. , Werner Martin 
Published: October 2023

AbstractSurface processes alter the water stable isotope signal of the surface snow after deposition. However, it remains an open question to which extent surface post‐depositional processes should be considered when inferring past climate information from ice core records. Here, we present simulations for the Greenland Ice Sheet, combining outputs from two climate models with an isotope‐enabled snowpack model. We show that surface vapor exchange and associated fractionation imprint a climate signal into the firn, resulting in an increase in the annual mean value of δ18O by +2.3‰ and a reduction in d‐excess by −6.3‰. Further, implementing isotopic fractionation during surface vapor exchange improves the representation of the observed seasonal amplitude in δ18O from 65.0% to 100.2%. Our results stress that surface vapor exchange is important in the climate proxy signal formation and needs consideration when interpreting ice core climate records.
Jovian Magnetospheric Injections Observed by the Hubble Space Telescope and Juno
Authors: Nichols J. D. , Allegrini F. , Bagenal F. , Bonfond B. , Clark G. B. , Clarke J. T. , Connerney J. E. P. , Cowley S. W. H. , Ebert R. W. , Gladstone G. R. , Grodent D. , Haggerty D. K. , Mauk B. , Orton G. S. , Provan G. , Wilson R. J. 
Published: October 2023

AbstractWe compare Hubble Space Telescope observations of Jupiter's FUV auroras with contemporaneous conjugate Juno in situ observations in the equatorial middle magnetosphere of Jupiter. We show that bright patches on and equatorward of the main emission are associated with hot plasma injections driven by ongoing active magnetospheric convection. During the interval that Juno crossed the magnetic field lines threading the complex of auroral patches, a series of energetic particle injection signatures were observed, and immediately prior, the plasma data exhibited flux tube interchange events indicating ongoing convection. This presents the first direct evidence that auroral morphology previously termed “strong injections” is indeed a manifestation of magnetospheric injections, and that this morphology indicates that Jupiter's magnetosphere is undergoing an interval of active iogenic plasma outflow.
Hydrologic and Organic Carbon Quality Controls on Nitrous Oxide Dynamics Across a Variably Confined Karst Aquifer
Authors: Flint M. K. , Martin J. B. , Oberhelman A. , Janelle A. J. , Black M. , Barry‐Sosa A. , Christner B. C. 
Published: October 2023

AbstractAtmospheric concentrations of the potent greenhouse gas nitrous oxide (N2O) have increased approximately 20% since the pre‐industrial era. Riverine systems represent an important atmospheric source of N2O however, the influence of varying hydrogeological conditions and dissolved organic carbon (DOC) quantity and quality on N2O dynamics remains poorly understood. We investigate effects of these processes on N2O dynamics in the Santa Fe River watershed in north‐central Florida, USA where a gradient in DOC quantity and quality is caused by varying surface water‐groundwater exchange. The watershed is underlain by the karstic Floridan aquifer, which is confined in the headwaters and contains terrigenous recalcitrant DOC, while the unconfined lower reaches contain protein‐like labile DOC substrates. Where extensive surface water‐groundwater exchange occurs at the boundary between the confined and unconfined aquifer, incomplete denitrification raises N2O concentration to 6.1 μg N‐N2O L−1, approximately 20 times greater than the concentration expected from equilibration with atmospheric N2O. These elevated concentrations create average local fluxes reaching ∼950 μg N‐N2O m−2 hr−1 within the mixing zone. Summation of spatially explicit emission estimates for upstream, mixing zone, and downstream river sections yield a total average emission rate of ∼3,758 kg N‐N2O yr−1. Despite having the smallest surface area across the river transect (∼8%), emissions from the mixing zone account for 26% of the total river emission rate. These findings highlight the potential contributions from karst landscapes to N2O cycling caused by varying redox conditions during surface water‐groundwater exchange, which creates hotspots of N2O production and emissions.
Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy
Authors: Bie Nana , Yong Tuying , Wei Zhaohan , Liang Qingle , Zhang Xiaoqiong , Li Shiyu , Li Xin , Li Jianye , Gan Lu , Yang Xiangliang 
Published: October 2023

AbstractImmune checkpoint blockade (ICB) therapy, particularly antibodies targeting the programmed death receptor 1 (PD-1) and its ligand (PD-L1), has revolutionized cancer treatment. However, its efficacy as a standalone therapy remains limited. Although ICB therapy in combination with chemotherapy shows promising therapeutic responses, the challenge lies in amplifying chemotherapy-induced antitumor immunity effectively. This relies on efficient drug delivery to tumor cells and robust antigen presentation by dendritic cells (DCs). Here, we developed tumor-repopulating cell (TRC)-derived microparticles with exceptional tumor targeting to deliver doxorubicin (DOX@3D-MPs) for improve anti-PD-1 therapy. DOX@3D-MPs effectively elicit immunogenic tumor cell death to release sufficient tumor antigens. Heat shock protein 70 (HSP70) overexpressed in DOX@3D-MPs contributes to capturing tumor antigens, promoting their phagocytosis by DCs, and facilitating DCs maturation, leading to the activation of CD8+ T cells. DOX@3D-MPs significantly enhance the curative response of anti-PD-1 treatment in large subcutaneous H22 hepatoma, orthotopic 4T1 breast tumor and Panc02 pancreatic tumor models. These results demonstrate that DOX@3D-MPs hold promise as agents to improve the response rate to ICB therapy and generate long-lasting immune memory to prevent tumor relapse.
Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Authors: Wang Yao , Tong Chuan , Lu Yuting , Wu Zhiqiang , Guo Yelei , Liu Yang , Wei Jianshu , Wang Chunmeng , Yang Qingming , Han Weidong 
Published: October 2023

AbstractAlthough chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies, more than 60% of patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR-T cell therapies fail to achieve a durable response. To reveal changes in CAR-T cell therapy and identify response biomarkers, we conducted a retrospective analysis of pre-manufacture source T cells and CAR-T cell products and their association with outcome in 58 patients with r/rDLBCL who received tandem CD19/CD20 CAR-T cell therapy. We performed bulk RNA-Seq, single-cell RNA-Seq, and paired T cell receptor sequencing on CAR-T cell products and pre-manufacture T cells from DLBCL patients. We note that a CD8+ stem cell-like memory T cell population with a higher proportion and enhanced activating capacity of the CAR-T cell products was key to achieving durable clinical response. By analysing autologously-derived, pre-manufacture T cells, our data suggest that heterogeneity in the cellular and molecular features of pre-manufacture T cells contribute to the variation in efficacy after CAR-T cell therapy in DLBCL. The differences in anti-tumour efficacy of CAR-T cells among patients with different clinical outcomes appear to be due to the loss of CCR7 gene expression, coupled with increased expression of activation- and inhibitor-related genes in the CD8+ naïve-T cell populations among the apheresis T cells from patients with a poor molecular response. These findings significantly advance our understanding of the underlying molecular determinants of pre-manufacture T cell function.
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A
Authors: Martin-Broto Javier , Martinez-Garcia Jeronimo , Moura David S. , Redondo Andres , Gutierrez Antonio , Lopez-Pousa Antonio , Martinez-Trufero Javier , Sevilla Isabel , Diaz-Beveridge Roberto , Solis-Hernandez Maria Pilar , Carnero Amancio , Perez Marco , Marcilla David , Garcia-Foncillas Jesus , Romero Pablo , Fernandez-Jara Javier , Lopez-Lopez Daniel , Arribas Ivan , Hindi Nadia 
Published: October 2023

AbstractCyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK inhibitors. Preclinical investigators of this study found that CDK4 overexpression, while not of CDKN2A, was the most consistent predictive factor for palbociclib efficacy in sarcomas. Advanced adult-type soft-tissue sarcoma, excluding DD-LPS, or bone sarcoma patients, progressing after at least one systemic line, whose tumors overexpressed CDK4, but not CDKN2A at baseline biopsy, were accrued in this single-arm phase II trial (EudraCT number: 2016-004039-19). With the main endpoint of a 6-month PFS rate, 40% was considered promising in this population. Palbociclib was administered orally at 125 mg/day for 21 days in 28-day cycles. A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening, archival material (141), and screening, baseline biopsy (95). There were 28 (29%) with favorable mRNA profiles from 95 screened patients at baseline. From 23 enrolled patients, 21 evaluable, the 6-month PFS rate was 29% (95% CI 9–48), and there were 6 patients out of 21 with a PFS longer than 6 months. The median PFS and overall survival were 4.2 (95% CI 3.6–4.8) and 12 (95% CI 8.7–15.4) months, respectively. Translational research showed a significant correlation between CDK4 mRNA and protein expression. Palbociclib was active in a variety of sarcoma subtypes, selected by CDK4/CDKN2A, and deserves further investigation in the sarcoma context.
Diverse electron carriers drive syntrophic interactions in an enriched anaerobic acetate-oxidizing consortium
Authors: McDaniel Elizabeth A , Scarborough Matthew , Mulat Daniel Girma , Lin Xuan , Sampara Pranav S , Olson Heather M , Young Robert P , Eder Elizabeth K , Attah Isaac K , Markillie Lye Meng , Hoyt David W , Lipton Mary S , Hallam Steven J , Ziels Ryan M 
Published: October 2023

AbstractIn many anoxic environments, syntrophic acetate oxidation (SAO) is a key pathway mediating the conversion of acetate into methane through obligate cross-feeding interactions between SAO bacteria (SAOB) and methanogenic archaea. The SAO pathway is particularly important in engineered environments such as anaerobic digestion (AD) systems operating at thermophilic temperatures and/or with high ammonia. Despite the widespread importance of SAOB to the stability of the AD process, little is known about their in situ physiologies due to typically low biomass yields and resistance to isolation. Here, we performed a long-term (300-day) continuous enrichment of a thermophilic (55 °C) SAO community from a municipal AD system using acetate as the sole carbon source. Over 80% of the enriched bioreactor metagenome belonged to a three-member consortium, including an acetate-oxidizing bacterium affiliated with DTU068 encoding for carbon dioxide, hydrogen, and formate production, along with two methanogenic archaea affiliated with Methanothermobacter_A. Stable isotope probing was coupled with metaproteogenomics to quantify carbon flux into each community member during acetate conversion and inform metabolic reconstruction and genome-scale modeling. This effort revealed that the two Methanothermobacter_A species differed in their preferred electron donors, with one possessing the ability to grow on formate and the other only consuming hydrogen. A thermodynamic analysis suggested that the presence of the formate-consuming methanogen broadened the environmental conditions where ATP production from SAO was favorable. Collectively, these results highlight how flexibility in electron partitioning during SAO likely governs community structure and fitness through thermodynamic-driven mutualism, shedding valuable insights into the metabolic underpinnings of this key functional group within methanogenic ecosystems.
A Large Finer-grained Affective Computing EEG Dataset
Authors: Chen Jingjing , Wang Xiaobin , Huang Chen , Hu Xin , Shen Xinke , Zhang Dan 
Published: October 2023

AbstractAffective computing based on electroencephalogram (EEG) has gained increasing attention for its objectivity in measuring emotional states. While positive emotions play a crucial role in various real-world applications, such as human-computer interactions, the state-of-the-art EEG datasets have primarily focused on negative emotions, with less consideration given to positive emotions. Meanwhile, these datasets usually have a relatively small sample size, limiting exploration of the important issue of cross-subject affective computing. The proposed Finer-grained Affective Computing EEG Dataset (FACED) aimed to address these issues by recording 32-channel EEG signals from 123 subjects. During the experiment, subjects watched 28 emotion-elicitation video clips covering nine emotion categories (amusement, inspiration, joy, tenderness; anger, fear, disgust, sadness, and neutral emotion), providing a fine-grained and balanced categorization on both the positive and negative sides of emotion. The validation results show that emotion categories can be effectively recognized based on EEG signals at both the intra-subject and the cross-subject levels. The FACED dataset is expected to contribute to developing EEG-based affective computing algorithms for real-world applications.
Chinese stroke patients with atrial fibrillation used Robert's age-adjusted warfarin loading protocol obtained good INR results within therapeutic range
Authors: Luo Weiliang , Luo Xuanwen , Chen Suqin , Li Jiming , Huang Xiaodong , Rao Yu , Xu Wengsheng 
Published: October 2023

AbstractTo assess whether Roberts’ age-adjusted warfarin loading protocol is effective in Chinese patients and whether the SAMeTT2R2 score can predict international normalized ratio (INR) control. Roberts’ protocol for warfarin titration was applied to patients with non-valvular atrial fibrillation (NVAF) complicated with ischemic stroke at the Department of Neurology between 2014 and 2019. Clinical and sociodemographic variables were recorded. A minimum of 1-year follow-up was used to calculate the time in therapeutic range (TTR) of the INR. A total of 94 acute ischemic stroke patients with NVAF were included in the study. Seventy-seven (81.9%) of the patients had attained stable INR (2.0–3.0) at the fifth dose, and 90.0% of the patients had achieved stable INR on the ninth day. Seventeen (18.1%) of the patients had an INR > 4 during dose-adjustment period. Patients with INR > 4 had significantly lower body weight (53.8 vs. 63.1 kg, P = 0.014), lower rate of achievement of stable INR (35.3% vs. 92.2%, P = 0.000), and lower rate of TTR ≥ 65% (23.5% vs. 70.1%, P = 0.001), but with no significant increase in bleeding risk. A total of 89 patients underwent long-term INR follow-up, of which 58 (65.2%) patients achieved TTR ≥ 65%. Patients with poor TTR had significantly lower body weight (56.3 vs. 63.7 kg, P = 0.020) and lower rate of stable INR achievement (64.5% vs. 89.7%, P = 0.002). All 94 patients had SAMeTT2R2 score ≥ 2. There was no linear association between SAMeTT2R2 score and the rate of TTR ≥ 65% (Ptrend = 0.095). Chinese ischemic stroke patients with NVAF on warfarin can safely and quickly achieve therapeutic INR using Roberts’ age-adjusted protocol and can obtain a good TTR. Lower body weight may be a predictor of poor TTR and INR > 4. Patients who have not attained stable INR after adjusting the dose five times are at high risk for poor TTR. SAMeTT2R2 score may not predict TTR in Chinese ischemic stroke patients with NVAF.