bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating ability in head and neck cancer patients after treatment with chemoradiation: A 12‐month follow‐up study accounting for dropout
Authors: Rademaker Alfred W. , Vonesh Edward F. , Logemann Jeri A. , Pauloski Barbara Roa , Liu Dachao , Lazarus Cathy L. , Newman Lisa A. , May Annette Hamner , MacCracken Ellen , Gaziano Joy , Stachowiak Linda 
Published: June 2004

AbstractBackground.Head and neck cancer patients treated with chemoradiation have difficulty eating a normal diet. This study was designed to characterize eating ability over 12 months after chemoradiation treatment. Analyses take patient dropout into account.Methods:Two hundred fifty‐five patients with head and neck cancer treated with chemoradiation were followed for 12 months. Eating ability was analyzed using generalized linear model methods that accounted for non‐ignorable dropout.Results.Eating ability was compromised immediately after treatment and improved over 12 months to near pretreatment levels. Ability to eat at most 50% of the diet orally did not return to baseline levels (p < .05). However, the percent of patients eating a normal diet did return to baseline levels. Accounting for dropout modified the results, but the pattern of significance was similar.Conclusions.Treatment of head and neck cancer with chemoradiation has a significant effect on eating ability, which improves after 12 months after treatment. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: Part 1, pathogenesis and prophylaxis of mucositis
Authors: Scully Crispian , Epstein Joel , Sonis Stephen 
Published: June 2004

AbstractBackground.Oral mucositis is a common sequel of radiotherapy, chemotherapy, and radiochemotherapy in patients with cancer or patients requiring hemopoietic stem cell transplants. Mucositis has a direct and significant impact on the duration of disease remission and cure rates, because it is a cancer treatment–limiting toxicity. Mucositis also affects survival because of the risk of infection and has a significant impact on the quality of life and cost of care.Methods.This article reviews publications on the etiopathogenesis and prevention of oral mucositis accessible from a MEDLINE search using as key words, mucositis, radiotherapy, chemotherapy, hemopoietic stem cell transplant, and oral.Conclusions.Of the current available products, ice chips and benzydamine have the strongest scientific evidence of support for prophylaxis of mucositis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Benign metastasizing pleomorphic adenoma of the parotid gland: A clinicopathologic puzzle
Authors: Marioni Gino , Marino Filippo , Stramare Roberto , Marchese‐Ragona Rosario , Staffieri Alberto 
Published: June 2004

AbstractBackground.Pleomorphic adenoma constitutes the most common benign parotid gland tumor. Local recurrence after surgical treatment (lateral or total parotidectomy) has been described in 1% to 5% of cases. Malignant degeneration has been reported in 2% to 9% of cases of pleomorphic adenoma of salivary gland origin. Metastasizing pleomorphic adenomas without histologic evidence of malignancy have rarely been reported. Metastatic lesions have been discovered in bone, lymph nodes, the lung, oral cavity, pharynx, skin, liver, retroperitoneum, kidney, calvarium, and central nervous system. To the best of our knowledge, we hereby report the first case of pleomorphic adenoma of the parotid gland metastasizing to the ipsilateral maxilla.Methods.We simultaneously examined apoptosis‐related protein expression and markers of cell‐proliferation activity in our case of benign pleomorphic adenoma metastasis and compared outcome with a control group of primary parotid pleomorphic adenomas.Results.Analysis of p53, Bcl‐2, MIB1, CD 105, p27, and p21 expression did not reveal significant differences between metastasizing pleomorphic adenoma of the salivary gland and the control group of primary parotid pleomorphic adenomas.Conclusions.Clinical rather than pathologic evidence seems to justify inclusion of metastasizing salivary pleomorphic adenoma in the group of low‐grade malignant salivary tumors. © 2003 Wiley Periodicals, Inc. Head and Neck 25: 000–000, 2003
Vertical ramus osteotomy combined with a parasymphyseal mandibulotomy for improved access to the parapharyngeal space
Authors: Smith Graham I. , Brennan Peter A. , Webb Andrew A. , Ilankovan Vellupilai 
Published: June 2004

AbstractBackground.A number of procedures have been described that facilitate access to the parapharyngeal space. Their use may be limited because of restricted access or postoperative morbidity.Methods.We describe the use of two mandibular osteotomies to greatly enhance the exposure of the parapharyngeal space, with possible access up to the skull base.Results.We have performed this procedure in three cases with minimal postoperative morbidity and no neurologic deficit or occlusal disturbances.Conclusions.We have found that the osteotomies described provide far better exposure to this area than a single mandibular osteotomy alone. Furthermore, it avoids a facial scar.
Sinonasal paraganglioma: Endoscopic resection with a 4‐year follow‐up
Authors: Mouadeb Debbie A. , Chandra Rakesh K. , Kennedy David W. , Feldman Michael 
Published: June 2004

AbstractBackground.Paragangliomas are uncommon neuroendocrine tumors. In the head and neck, they are most commonly seen at the carotid body, the temporal bone, or along the vagus nerve. Sinonasal paragangliomas are extremely rare. Most cases reported describe management by open surgical resection, with sublabial and/or transfacial approaches.Methods.We present a case of a large sinonasal paraganglioma successfully managed by endoscopic resection.Results.The patient has no evidence of recurrence after 4 years of follow‐up.Conclusions.This case demonstrates that sinonasal paragangliomas might be amenable to endoscopic resection. However, the most important priority to consider when selecting a surgical technique is whether adequate excision with clear margins can be obtained. Furthermore, because of the aggressive nature of these tumors, regardless of the surgical approach, long‐term follow‐up is recommended. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Early glottic carcinoma: Treatment according patient's preference?
Authors: Stoeckli Sandro J. , Schnieper Isabel , Huguenin Pia , Schmid Stephan 
Published: June 2004

AbstractBackground.To analyze the results in early (stage I and II) glottic carcinoma of a single institution with a patient‐oriented concept.Methods.After diagnostic workup and multidisciplinary counseling, either radiotherapy or CO2 laser surgery was chosen with respect to the patient's preference.Results.Sixty‐five patients underwent laser surgery and 75 had radiotherapy. For T1 tumors, the 5‐year overall survival, disease‐specific survival, and initial local control rate after laser surgery and radiotherapy were comparable (OS, 85% vs 88%; DSS, 96% vs 93%; LCR, 86% vs 85%). In contrast, initial local control for T2 tumors was significantly more favorable after surgery (OS, 83% vs 78%; DSS, 83% vs 88%; LCR, 89% vs 67%). Larynx preservation was significantly higher after surgery in T1 tumors (96% vs 82%) and in T2 tumors (89% vs 77%).Conclusions.Selection of the treatment modality according to patient's preference results in a comparable control of disease for T1 tumors. The initial local control for T2 tumors is significantly better after surgery. In both stages laser surgery warrants a better larynx preservation rate. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Patient's response using freetext in the University of Washington Quality of Life Scale
Authors: Millsopp Lynne , Humphris Gerry , Lowe Derek , Rogers Simon Neave 
Published: June 2004

AbstractBackground.The University of Washington Quality of Life Scale is the only validated head‐and‐neck–specific questionnaire that invites patients to write comments in the form of freetext. Freetext allows the questionnaire to record issues raised by the patient.Method.Two hundred seventy‐eight consecutive patients treated between 1995 and 1999 by primary surgery for oral and oropharyngeal squamous cell carcinoma completed the UWQOL. Freetext from these patients was independently assessed by the authors.Results.Comments were made by 61% of patients at some time. Completion was independent of clinicodemographic characteristics. Comments were predominantly head and neck (39%) and medical (35%). In 55% of cases, the overall tone was negative. Around a quarter of issues was not part of a validated health‐related quality‐of‐life questionnaire.Conclusions.Freetext gives the multidisciplinary team a better insight into the concerns of the patient and can be used to promote a holistic approach. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Impact of comorbidity on the outcome of laryngeal squamous cancer
Authors: Paleri Vinidh , Wight Richard G. , Davies Gareth R. 
Published: June 2004

AbstractBackground.Comorbidity has been shown to be a determinant in treatment selection and survival in various cancers. We have previously shown that the Adult Comorbidity Evaluation—27 index is applicable in a United Kingdom setting, and the process of comorbidity grading by retrospective notes evaluation is an accurate and reliable process.Methods.The impact of comorbidity and other factors on survival was examined retrospectively in a cohort of 180 patients with laryngeal squamous cell cancer.Results.This study shows for the first time that the higher comorbidity burden seen in supraglottic cancers in contrast to glottic tumors might account for the poorer prognosis. This study also externally validates the composite comorbidity–TNM staging system described by Piccirillo and shows the composite system to be a better predictor of outcome than TNM staging system alone.Conclusions.Moderate and severe comorbidity have a greater and statistically significant impact on survival than the TNM staging system. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Carcinoma of the skin with perineural invasion
Authors: Garcia‐Serra Allie , Hinerman Russell W. , Mendenhall William M. , Amdur Robert J. , Morris Christopher G. , Williams Lorna Sohn , Mancuso Anthony A. 
Published: June 2004

AbstractPurpose.To evaluate the outcome and patterns of relapse in patients treated for skin carcinoma of the head and neck with either microscopic or clinical perineural invasion.Methods and Materials.Radiotherapy alone or combined with surgery was used to treat 135 patients with microscopic or clinical evidence of perineural invasion of skin carcinoma. All patients had at least 2 years of follow‐up.Results.The 5‐year local control rates without salvage therapy were 87% with microscopic perineural invasion and 55% with clinical perineural invasion. Overall, 88% of the local failures occurred in patients with positive margins. Almost half of the recurrences in patients with microscopic perineural invasion were limited to the first‐echelon regional nodes. However, only 1 of 11 patients with basal cell carcinoma with microscopic perineural invasion had a nodal failure. Ninety percent of recurrences in patients with clinical perineural invasion occurred at the primary site. Cranial nerve deficits rarely improved after successful treatment of the primary disease. Radiographic abnormalities remained stable 30% of the time when patients had clinical evidence of progressive disease.Conclusions.Radiotherapy in patients with skin cancer with clinical perineural invasion should include treatment of the first‐echelon regional lymphatics. The risk of regional node involvement is also relatively high for patients with squamous cell carcinoma with microscopic perineural invasion. In patients with clinical perineural invasion, the poor local control rates with conventional radiotherapy suggest a need for dose escalation with or without concomitant chemotherapy. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Depressive symptoms during and after radiotherapy for head and neck cancer
Authors: Sehlen Susanne , Lenk Marcus , Herschbach Peter , Aydemir Uelker , Dellian Marc , Schymura Beatrice , Hollenhorst Helmuth , Dühmke Eckhart 
Published: June 2004

AbstractBackground.Patients with head and neck cancer are extraordinarily susceptible to depressive traits. Thus, a general screening of these patients at their first admission to the ital is desirable.Methods.From 1997–2001, 133 patients with head and neck tumors filled in the Self‐Rating‐Depression‐Scale (SDS) at the beginning and end of radiotherapy (ti1/ti2), 6 weeks, and 6 months after radiotherapy (ti3/ti4).Results.The SDS index increased significantly from 46.44 (ti1) to 48.91(ti2) (p = .025) and then remained stable. The subdomain “somatic‐eating‐related symptoms” at ti1 was significantly lower than ti2 (p < .001). In contrast to inpatients, outpatients and those with conventional instead of hyperfractionated‐accelerated radiotherapy were less impaired by eating‐related symptoms. Patients with higher education showed a lower SDS index and cognitive scale. Marital status, tumor stage, histologic grading, and substance abuse had no influence.Conclusions.Patients with a higher risk of depression should receive long‐term monitoring during and after the end of radiotherapy, and prompt intervention strategies should be applied. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Photoaddition Reactions of Benzoxazole‐2(3H)‐thiones to Cycloalkenes and Heteroaromatics
Authors: Nishio Takehiko , Shiwa Kiyoko , Sakamoto Masami 
Published: June 2004

AbstractPhotoaddition reactions of benzoxazole‐2‐thiones 1 with cycloalkenes 2 and heteroaromatics 3 were examined. Irradiation of N‐acylbenzoxazole‐2‐thiones 1a and 1b, and 3‐(methoxycarbonyl)‐ and 3‐(phenoxycarbonyl)benzoxazole‐2(3H)‐thiones (1f and 1h, resp.) in the presence of cycloalkenes 2a–2c, cyclohexa‐1,4‐diene (2d), and indene (2e) yielded 2‐substituted benzoxazoles 4–13, 18 and 19, and iminothietanes 14–17, by intramolecular trapping of the acyl or MeOCO and PhOCO groups by thiolate anion of the zwitterionic intermediate I and by the phenolate anion of the zwitterionic intermediate II, respectively, derived from the spirocyclic amino‐thietanes AT formed by [2+2] cycloaddition of the CS bond of 1 and CC bond of 2. Irradiation of 1 in the presence of heteroaromatics 3 gave the 2‐substituted benzoxazoles 20–33 exclusively.
A Theoretical Study of Correlation between Hydrogen‐Bond Stability and J‐Coupling through a Hydrogen Bond
Authors: Kawahara Shun‐ichi , Kojima Chojiro , Taira Kazunari , Uchimaru Tadafumi 
Published: June 2004

Abstracttrans‐Hydrogen‐bond hyperfine splitting via magnetic interaction, which is observed as J‐coupling in NMR experiments, was theoretically studied. trans‐Hydrogen‐bond hyperfine splitting should be closely related to the orbital interaction between the lone‐pair orbital of the H‐bond acceptor and the antibond orbital of the H‐bond donor. A linear relationship was observed between magnetic interaction hyperfine splitting through a H‐bond and the H‐bond strength. The relationship was dependent on the type of the nucleus forming the H‐bond; linear correlation was observed in NH⋅⋅⋅O/N type or OH⋅⋅⋅N type H‐bonded complexes, but not in OH⋅⋅⋅O type H‐bonded complexes.
Etorphine‐Related Ferrocenyl‐Substituted Morphinan Alkaloids
Authors: Laus Gerhard , Schütz Johannes , Schottenberger Herwig , Andre Max , Wurst Klaus , Spetea Mariana , Ongania Karl‐Hans , Müller Adrian G. , Schmidhammer Helmut 
Published: June 2004

AbstractThe two diastereoisomeric ferrocenyl‐substituted orvinols 2 and 3 were prepared. The modified alkaloids are still able to interact with opioid receptors (see Table). The ferrocene moiety allows highly selective and sensitive electrochemical detection. The X‐ray crystal structure of the major isomer 2 was determined. The combination of a metallocene and a morphinan alkaloid holds promise for useful antitumor activity.
The Synthesis, Characterisation, and Reactivity of Some Polydentate Phosphinoamine Ligands with Benzene‐1,3‐diyl and Pyridine‐2,6‐diyl Backbones
Authors: Biricik Nermin , Fei Zhaofu , Scopelliti Rosario , Dyson Paul J. 
Published: June 2004

AbstractThe polydentate phosphinoamines 1,3‐{(Ph2P)2N}2C6H4 and 2,6‐{(Ph2P)2N}2C5H3N have been prepared in a single step from the reaction of the amines 1,3‐(NH2)2C6H4 or 2,6‐(NH2)2C5H3N with Ph2PCl in presence of Et3N (1 : 4 : 4 molar ratio) in CH2Cl2. Reaction of 1,3‐{(Ph2P)2N}2C6H4 or 2,6‐{(Ph2P)2N}2C5H3N with elemental sulfur or selenium in CH2Cl2 affords the corresponding tetrasulfide or tetraselenide, respectively, in good yield. The complexes [1,3‐{Mo(CO)4(Ph2P)2N}2(C6H4)] and [2,6‐{Mo(CO)4(Ph2P)2N}2(C5H3N)] were prepared from the reaction of these phosphinoamines with [Mo(CO)4(nbd)] (nbd=norbornadiene) in toluene, and the structure of the latter complex has been determined by single‐crystal X‐ray diffraction analysis.
Challenges in Modelling and Optimization of Stability Constants in the Study of Metal Complexes with Monoprotonated Ligands. Part II
Authors: Machado Carina M. M. , Cukrowski Ignacy , Soares Helena M. V. M. 
Published: June 2004

AbstractThe influence of 2‐hydroxy‐3‐[(2‐hydroxy‐1,1‐dimethylethyl)amino]propane‐1‐sulfonic acid (AMPSO=HL) on systems containing copper(II) was studied by glass‐electrode potentiometry (GEP) and direct‐current polarography (DCP), at fixed total‐ligand‐to‐total‐metal‐concentration ratios and various pH values (25°, 0.1M KNO3 medium). The predicted model ([CuL]+, [CuL(OH)], [CuL2], [CuL2(OH)]−, [CuL2(OH)2]2−, and [CuL3]−) and the overall stability constants for species found were obtained by combining results from both electrochemical techniques. The last five complexes are reported for the first time. For the species [CuL]+, [CuL2], [CuL3]−, and [CuL2(OH)2]2−, it was possible to determine stability constants with reasonable certainty and their values, as log β, were found to be 4.62±0.04, 9.5±0.1, 13.4±0.1, and 21.2±0.1, respectively. For the species [CuL(OH)] and [CuL2(OH)]−, stability constants 11.7±0.2 and 15.6±0.2, respectively, are presented as indicative values. It was demonstrated that AMPSO buffer may decrease the Cu2+ concentration by ten orders of magnitude by forming complexes with Cu2+. For the first time, the correction in DCP waves for the adsorption of the ligand and quasi‐reversibility of the metal allowed to determine stability‐constant values that are in good agreement with the values obtained by GEP. The importance of graphic analysis of data and significance of employing two analytical techniques was demonstrated; neither GEP nor DCP would be able to provide the correct M/L/OH− model and reliable stability constants when used independently.
A New Glycoside and a Novel‐Type Diterpene from Hemerocallis fulva (L.) L.
Authors: Yang Zhong‐duo , Chen Hua , Li Yuan‐chao 
Published: June 2004

AbstractThe CHCl3 extract of dried roots of Hemerocallis fulva (L.) L. afforded a novel diterpene named hemerocallal A (1), which is the second reported naturally occurring diterpene with a trans‐bicyclo[5.1.0]octane system. The BuOH extract afforded a new glycoside named hemerocalloside (2). Their structures were established on the basis of spectroscopic and chemical studies.
A Concise Synthesis of 2‐Amino‐1,2,3,4‐tetrahydronaphthalene‐6,7‐diol (‘6,7‐ADTN’) from Naphthalene‐2,3‐diol
Authors: Göksu Süleyman , Kazaz Cavit , Sütbeyaz Yaşar , Seçen Hasan 
Published: June 2004

Abstract2‐Amino‐1,2,3,4‐tetrahydronaphthalene‐6,7‐diol (2; 6,7‐ADTN) was synthesized starting from naphthalene‐2,3‐diol in seven steps and with an overall yield of 44%. Methylation of naphthalene‐2,3‐diol with dimethyl sulfate, followed by FriedelCrafts acylation with AcCl, gave 2‐acetyl‐6,7‐dimethoxynaphthalene. 2‐Acetyl‐6,7‐dimethoxynaphthalene was converted to 6,7‐dimethoxynaphthalene‐2‐carboxylic acid by a haloform reaction. Birch reduction of the carboxylic acid with 4 mol‐equiv. of Na in liquid ammonia afforded 1,2,3,4‐tetrahydro‐6,7‐dimethoxynaphthalene‐2‐carboxylic acid, from which 2 was obtained by a Curtius reaction, followed by hydrogenolysis and demethylation.
New Synthesis of Natural Carotene Isorenieratene (ϕ,ϕ‐Carotene) and its 3,3′‐Dimethoxy Analogue
Authors: Valla Alain R. , Cartier Dominique L. , Valla Benoist G. , Le Guillou Régis Y. , Andriamialisoa Zo R. , Labia Roger , Breithaupt Dietmar E. , Savy Stéphanie M. , Binet Adrien , Dufossé Laurent H. 
Published: June 2004

AbstractThe main pigments of Brevibacterium linens are the aromatic carotenoids 3,3′‐dihydroxyisorenieratene (φ,φ‐carotene‐3,3′‐diol), the corresponding monohydroxy compound, and the hydrocarbon isorenieratene. We report herein new syntheses of isorenieratene (ϕ,ϕ‐carotene) and its xanthophyll analogue, 3,3′‐dimethoxy‐ϕ,ϕ‐carotene, which may be considered a protected form of the natural xanthophyll, 3,3′‐dihydroxy‐ϕ,ϕ‐carotene.
Antitumor Sesquiterpenes from Euonymus nanoides
Authors: Wang Hong , Tian Xuan , Pan Yuanjiang 
Published: June 2004

AbstractThe isolation, structure elucidation, and antitumor activity of four new sesquiterpene polyol esters, i.e., of 6α,13‐bis(acetyloxy)‐9β‐(cinnamoyloxy)‐1β‐(furan‐3‐ylcarbonyl)oxy]‐4α‐hydroxy‐β‐dihydroagarofuran (1), 13‐(acetyloxy)‐9β‐(benzoyloxy)‐4α‐hydroxy‐1β,6α‐bis[(2‐methylbutanoyl)oxy]‐β‐dihydroagarofuran (2), 1β,6α,13‐ tri(acetyloxy)‐9β‐(cinnamoyloxy)‐4α‐hydroxy‐β‐dihydroagarofuran (3), and 6α,13‐bis(acetyloxy)‐9β‐(benzoyloxy)‐4α‐hydroxy‐1β‐[(2‐methylbutanoyl)oxy]‐β‐dihydroagarofuran (4), and of five known sesquiterpene polyol esters 5–9 from the seed oil of Euonymus nanoides Loes. are reported (β‐dihydroagarofuran=octahydro‐2,2,5a,9‐tetramethyl‐2H‐3,9a‐methano‐1‐benzoxepin).
Synthesis of N‐[(tert‐Butoxy)carbonyl]‐3‐(9,10‐dihydro‐9‐oxoacridin‐2‐yl)‐L‐alanine, a New Fluorescent Amino Acid Derivative
Authors: Szymańska Aneta , Wegner Katarzyna , Łankiewicz Leszek 
Published: June 2004

AbstractA simple synthesis of a new, highly fluorescent amino acid and of its protected derivative useful in peptide studies is described. The obtained derivative, N‐[(tert‐butoxy)carbonyl]‐3‐(9,10‐dihydro‐9‐oxoacridin‐2‐yl)‐L‐alanine (6), shows intense long‐wave absorption (above 360 nm) and emission (above 400 nm). The quantum yield of fluorescence of the investigated compound is very high, so it can serve as a sensitive analytical probe useful, e.g., in analysis of peptide conformations.
Controlled Synthesis of Substituted Benzobasketene Derivatives
Authors: Aydinli Betül , Çelik Murat , Gültekin M. Serdar , Uzun Orhan , Balcı Metin 
Published: June 2004

AbstractThe addition of benzyne to trans‐7,8‐dibromobicyclo[4.2.0]octa‐2,4‐diene (6) led to the formation of dibromide 7. The dehydrobromination of 7 followed by replacement of the Br‐atom with a CN substituent gave 9. Photolysis of 9 in acetone at 254 nm yielded the desired monosubstituted benzobasketene derivative 10. Bromination of monobromide 8 followed by dehydrobromination furnished the symmetrically substituted dibromo compound 15. Further bromination of 7 followed by dehydrobromination resulted in the formation of the dibromides 20 and 21. Substitution of the Br‐atoms in 15, 20, and 21 with CN substituents and photolysis of the formed dicarbonitriles 16, 23, and 24 gave the target benzobasketene‐dicarbonitriles 17, 25, and 26, respectively.