bluuebunny/crossref_metadata_2025_split huggingface dataset:
HER2-targeted therapies in cancer: a systematic review
Authors: Zhu Kunrui , Yang Xinyi , Tai Hebei , Zhong Xiaorong , Luo Ting , Zheng Hong 
Published: February 2024

AbstractAbnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in molecular biology and further exploration of the HER2-mediated pathway have promoted the development of medicine design and combination drug regimens. An increasing number of HER2-targeted drugs including specific monoclonal antibodies, tyrosine kinase inhibitors (TKIs), and antibody-drug conjugates (ADCs) have been approved by the U.S. Food and Drug Administration. The emergence of ADCs, has significantly transformed the treatment landscape for various tumors, such as breast, gastric, and bladder cancer. Classic monoclonal antibodies and novel TKIs have not only demonstrated remarkable efficacy, but also expanded their indications, with ADCs in particular exhibiting profound clinical applications. Moreover the concept of low HER2 expression signifies a breakthrough in HER2-targeted therapy, indicating that an increasing number of tumors and patients will benefit from this approach. This article, provides a comprehensive review of the underlying mechanism of action, representative drugs, corresponding clinical trials, recent advancements, and future research directions pertaining to HER2-targeted therapy.
Brain injury drives optic glioma formation through neuron-glia signaling
Authors: Chatterjee Jit , Koleske Joshua P. , Chao Astoria , Sauerbeck Andrew D. , Chen Ji-Kang , Qi Xuanhe , Ouyang Megan , Boggs Lucy G. , Idate Rujuta , Marco Y Marquez Lara Isabel , Kummer Terrence T. , Gutmann David H. 
Published: February 2024

AbstractTissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory factor (cytokines, chemokines) elaboration. Their common pathobiology raises the intriguing possibility that brain injury could create a tissue microenvironment permissive for tumor formation. Leveraging several murine models of the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome and two experimental methods of brain injury, we demonstrate that both optic nerve crush and diffuse traumatic brain injury induce optic glioma (OPG) formation in mice harboring Nf1-deficient preneoplastic progenitors. We further elucidate the underlying molecular and cellular mechanisms, whereby glutamate released from damaged neurons stimulates IL-1β release by oligodendrocytes to induce microglia expression of Ccl5, a growth factor critical for Nf1-OPG formation. Interruption of this cellular circuit using glutamate receptor, IL-1β or Ccl5 inhibitors abrogates injury-induced glioma progression, thus establishing a causative relationship between injury and tumorigenesis.
Glyphosate detection via a nanomaterial-enhanced electrochemical molecularly imprinted polymer sensor
Authors: Aghoutane Youssra , Burhan Hakan , Sen Fatih , Bouchikhi Benachir , El Bari Nezha 
Published: February 2024

AbstractGlyphosate (GLY) is a widely used herbicide with an important role in agriculture. It effectively controls weeds, enhancing agricultural yield and product quality. However, its use raises significant concerns such as potential risks to non-target ecosystems and human health. In response to these concerns, we develop an electrochemical sensor with a molecularly imprinted polymer (MIP) and gold nanoparticles for GLY detection. The sensor includes a screen-printed carbon electrode (SPCE) functionalized with gold nanoparticles and a self-assembled polyvinyl carboxylic acid chloride (PVC-COOH) layer. GLY compounds interact with carboxylic groups and are encapsulated by a polymer of methacrylic acid (MAA) cross-linked with ethylene glycol dimethacrylate (EGDMA). Electrochemical performance was assessed using differential pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Morphological characterization was performed using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and atomic force microscopy (AFM). The sensor exhibits impressive selectivity, detecting GLY within a range of 273–1200 pg/mL with minimal interference from other pesticides. It boasts a low detection limit of 0.8 pg/mL (signal-to-noise ratio S/N = 3) by DPV and 0.001 pg/mL by EIS. The sensor’s versatility extends to various sample types, including surface water, agricultural wastewater, soil, and cucumber, demonstrating high recovery rates (> 96.05%) and low relative standard deviation (RSD) (< 5.7%). The developed MIP sensor is proven to be a valuable tool for rapid and highly sensitive detection of GLY in diverse environmental and agri-food samples.
Totally laparoscopic surgery for a hydrocele of the canal of Nuck extending from the abdominal cavity to the subcutaneous space: a case report
Authors: Nakamura Kenichi , Higashiguchi Takahiko , Chikaishi Yuko , Matsuo Kazuhiro , Endo Tomoyoshi , Morohara Koji , Kikuchi Kenji , Shibasaki Susumu , Katsuno Hidetoshi , Uyama Ichiro , Suda Koichi , Morise Zenichi 
Published: February 2024

Abstract
Background
Hydrocele of the canal of Nuck (HCN) is a rare disease, and its indications for laparoscopic surgery are not well-established.

Case presentation
A 53-year-old woman was referred to our hospital due to an uncomfortable thumb-sized inguinal mass. Preoperative computed tomography scan and magnetic resonance imaging revealed a hydrocele extending from the abdominal cavity around the left deep inguinal ring via the inguinal canal to the subcutaneous space. The patient was diagnosed with HCN protruding into the abdominal cavity and extending to the subcutaneous space. Laparoscopy can easily access the hydrocele protruding into the abdominal cavity. Furthermore, laparoscopic hernioplasty can be superior to the anterior approach for females. Hence, laparoscopic surgery was performed. After transecting the round ligament of the uterus, a tense 3-cm hydrocele was dissected with it. In order to approach the hydrocele distal to the deep inguinal ring, the transversalis fascia was incised medially to the inferior epigastric vessels. The subcutaneously connected hydrocele was excised from the incision. Then, the enlarged deep inguinal ring was reinforced using a mesh with the laparoscopic transabdominal preperitoneal approach. The patient was discharged 2 days postoperatively. Laparoscopic resection can be more effective for a hydrocele protruding into the abdominal cavity as it facilitates an easy access to the hydrocele. Moreover, laparoscopic resection of a hydrocele extending from the inguinal canal to the subcutaneous space via a transversalis fascia incision can be safer, with low risk of injury to the inferior epigastric vessels. The incised transversalis fascia and the enlarged deep inguinal ring due to the HCN were simultaneously repaired with the laparoscopic transabdominal preperitoneal repair. There are two reports on laparoscopic resection via a transversalis fascia incision for HCNs located between the inguinal canal and the subcutaneous space, which does not require intraperitoneal hydrocelectomy. However, this is the first report on laparoscopic resection of large HCNs protruding into the abdominal cavity and extending beyond the inguinal canal into the subcutaneous space via intraperitoneal hydrocelectomy and a transversalis fascia incision.

Conclusions
Laparoscopic surgery with transversalis fascia incision can be useful for HCNs extending from the abdominal cavity to the subcutaneous space.
Response of the consumers to the menu calorie-labeling on online food ordering applications in Saudi Arabia
Authors: Alkhunein Sarah , Alghafari Wejdan , Alzeer Haya , Alhumaidan Omar , Alsalman Sarah , Alshathry Nojoud , Alkhaldy Areej 
Published: February 2024

Abstract
Background
The use of online food ordering applications is widespread; however, to date, there have been no studies on the effect of the menu calorie labeling in online food ordering applications on the consumers’ dietary habits and food choices in Saudi Arabia. Therefore, this study aimed to evaluate the response of the consumers to the menu energy-labeling on online food ordering applications in Saudi Arabia by exploring: (a) the consumers’ preference and frequency of ordering from online food applications; (b) the consumers' self-reported knowledge, awareness, and interest towards menu calorie information on online food ordering applications; (c) the impact of menu calorie information on online food ordering applications on consumers’ food choices.

Methods
This is a cross-sectional study conducted between October and November of 2022. A total of 419 participants were recruited using an online questionnaire.

Results
The findings showed that most participants (59%) preferred to order using online food ordering applications. Saving time and effort are the main reasons for using online food ordering applications (61%). Nearly half of the participants (45%) were interested in viewing calorie information on online food ordering applications menus and (47%) did notice calorie information displayed on the menu when ordering from an online food ordering application. Calorie information in online food ordering applications menus is primarily utilized to monitor intake for weight maintenance (19%). The ability to calculate energy requirements and interest in viewing calorie information on online food ordering applications menus were linked to younger age and a higher level of education (p < 0.05).

Conclusions
Overall, consumers showed limited awareness and interest towards the menu calorie information displayed in the online food ordering applications. These findings highlight the importance of developing public health programs to increase public awareness about calorie labeling on menus to aid in the success and effectiveness of the calorie labeling in online food ordering applications as a tool to promote balanced energy intake. Further research is needed to understand the most effective way to deliver calorie information to consumers on an online food ordering application.
Spatial distribution and determinants of unmet need for family planning among all reproductive‑age women in Uganda: a multi‑level logistic regression modeling approach and spatial analysis
Authors: Belay Alemayehu Sayih , Sarma Haribondhu , Yilak Gizachew 
Published: February 2024

Abstract
Introduction
Unmet need for family planning is defined as the percentage of sexually active and fecund women who want to delay the next birth (birth spacing) or who want to stop childbirth (birth limiting) beyond two years but who are not using any modern or traditional method of contraception. Despite the provision of family planning services, the unmet need of family planning remains a challenge in low- and middle-income countries (LMICs). Thus, this study aimed to assess the spatial distribution and determinant factors of unmet need for family planning among all reproductive‑age women in Uganda.

Methods
A secondary data analysis was done based on 2016 Ugandan Demographic and Health Surveys (UDHS). Total weighted samples of 18,506 women were included. Data processing and analysis were performed using SPSS Version 26, STATA 14.2, ArcGIS 10.8, and SaTScan 10.1.2 software. Spatial autocorrelation and hotspot analysis was made using Global Moran’s index (Moran’s I) and Gettis-OrdGi*statistics, respectively. Determinants of unmet needs for family planning were identified by multi-level logistic regression analysis. Variables with a p-value < 0.05 were declared statistically significant predictors.

Results
The spatial distribution of unmet need for family planning among women of reproductive age in Uganda was found to be clustered (Global Moran’s I = 0.27, Z-score of 12.71, and p-value < 0.0001). In the multivariable multilevel logistic regression analysis; women in West Nile (AOR = 1.86, 95% CI: 1.39, 2.47), aged 25–49 years old (AOR = .84; 95% CI .72, .99), highly educated (AOR = .69; 95% CI .54, .88), Muslim (AOR = 1.20, 95% CI: 1.03, 1.39), high wealth status (AOR = .73, 95% CI: .64, .82), and had five or more living child (AOR = 1.69, 95% CI: 1.51, 1.88) were significant predictors of unmet need for family planning. Significant hotspot areas were identified in West Nile, Acholi, Teso, and Busoga regions.

Conclusion
A significant clustering of unmet need for family planning were found in Uganda. Moreover, age, educational status, religion, wealth status, number of alive children, and region were significant predictors of unmet need for family planning. Therefore, in order to minimize the burdens associated with unmet need, an interventions focusing on promotion of sexual and reproductive health service should be addressed to the identified hotspot areas.
Comparison of antiangiogenic agents (ranibizumab, aflibercept, bevacizumab and ziv-aflibercept) in the therapeutic response to the exudative form of age-related macular degeneration according to the treat-and-extend protocol- true head-to-head study
Authors: Kanadani Tereza , Rabelo Neiffer , Takahashi Denise , Magalhães Lucas , Farah Michel 
Published: February 2024

Abstract
Purpose
To evaluate the structural and functional changes in eyes with neovascular age related macular degeneration (nAMD) in a real-world setting, using Treat and Extend protocol (T&E), comparing four antiangiogenic agents.

Methods
Prospective, observational, case series study performed in 131 patients with the exudative form of nAMD. Patients were randomly assigned into four groups according to the antiangiogenic agent. During the first year, all eyes received at least 3 monthly intravitreal injections of antiangiogenic agents, and afterwards, were submitted to the T&E.

Results
There was statistically significant difference (p < 0.05) between pre- and post-treatment in the best corrected visual acuity measurements by drug used. Patients who used aflibercept had significantly fewer injections than patients using the other drugs (mean = 9.03). No significant difference was observed between the drugs bevacizumab, ranibizumab and ziv-aflibercept. With regard to biomarkers, patients who used aflibercept and had lower baseline central retinal thickness, absence of hyperreflective foci and no subretinal hyperreflective material had the lowest number of injections.

Conclusion
Results indicate that over 2 years, Intravitreal aflibercept on T&E provided better visual and anatomical improvements when compared to other drugs used in this study with significantly fewer injections.
Measured and simulated mechanical properties of additively manufactured matrix-inclusion multimaterials fabricated by material jetting
Authors: Kornfellner Erik , Königshofer Markus , Krainz Lisa , Krause Arno , Unger Ewald , Moscato Francesco 
Published: February 2024

AbstractModern additive manufacturing enables the simultaneous processing of different materials during the printing process. While multimaterial 3D printing allows greater freedom in part design, the prediction of the mix-material properties becomes challenging. One type of multimaterials are matrix-inclusion composites, where one material contains inclusions of another material. Aim of this study was to develop a method to predict the uniaxial Young’s modulus and Poisson’s ratio of material jetted matrix-inclusion composites by a combination of simulations and experimental data.Fifty samples from commercially available materials in their pure and matrix-inclusion mixed forms, with cubic inclusions, have been fabricated using material jetting and mechanically characterized by uniaxial tensile tests. Multiple simulation approaches have been assessed and compared to the measurement results in order to find and validate a method to predict the multimaterials’ properties. Optical coherence tomography and microscopy was used to characterize the size and structure of the multimaterials, compared to the design.The materials exhibited Young’s moduli in the range of 1.4 GPa to 2.5 GPa. The multimaterial mixtures were never as stiff as the weighted volume average of the primary materials (up to $$33.9\%$$

33.9
%

softer for 45% RGD8530-DM inclusions in VeroClear matrix). Experimental data could be predicted by finite element simulations by considering a non-ideal contact stiffness between matrix and inclusion ($$F_A=2.2\frac{TN}{m^3}$$

F
A

=
2.2

TN

m
3

for RGD8530-DM, $$F_A=4.8\frac{TN}{m^3}$$

F
A

=
4.8

TN

m
3

for RGD8430-DM), and geometries of the printed inclusions that deviated from the design (rounded edge radii of $$r=220\,\upmu$$

r
=
220

μ

m). Not considering this would lead to a difference of the estimation result of up to $$612\,$$

612

MPa (44%), simulating an inclusion volume fraction of 45% RGD8530-DM.Prediction of matrix-inclusion composites fabricated by multimaterial jetting printing, is possible, however, requires a priori knowledge or additional measurements to characterize non-ideal contact stiffness between the components and effective printed geometries, precluding therefore a simple multimaterial modelling.
Lactic acid fermented Elaeagnus multiflora Thunb. fruit: suppressive effect of its extracts on angiogenesis
Authors: Lizardo Rona Camille M. , Cho Hyun Dong , Seo Kwon Il 
Published: February 2024

Abstract
Background
Angiogenesis has been considered as one of the hallmarks of tumor progression and cancer malignancy. Meanwhile, the fruit of Elaeagnus multiflora Thunb. or cherry silverberry (CS), was found to have strong biological activities including anti-cancer and anti-angiogenesis. In this study, the influence of the extracts of E. multiflora Thunb. fruits fermented by mono- and co-culture of L. plantarum and L. casei on the new blood vessel formation in human umbilical vascular endothelial cell (HUVEC) stimulated by vascular endothelial growth factor (VEGF) as well as the underlying mechanism was elucidated.

Results
Sulforhodamine B, scratch wound-healing, Transwell migration, capillary-like tube formation, rat aortic ring assays, and morphological analysis were performed to determine the effect of the fermented fruit extracts on the VEGF-induced angiogenic events (motility, migration, invasion, formation of capillary-like tube, blood vessel sprouting ex vivo). The findings showed that at concentration of 25–50 µg/ml, the extracts of CS fermented by mixed cultures is the most effective in inhibiting angiogenesis in HUVECs. Moreover, analysis of the biomarker proteins related to angiogenesis through Western blot technique showed that the fermented extracts exert their anti-angiogenic activity by regulating the VEGFR2 signaling pathway and its possible downstream targets namely Erk ½ and FAK.

Conclusion
Taken together, the results suggest that the extracts of CS fruits fermented by co-culture of L. plantarum and L. casei has the potential to be utilized in the development of functional food and ingredient with anti-angiogenic properties.

Graphical Abstract
18F-Fluorodeoxyglucose positron emission tomography [18F-FDG PET CT] in assessment of patients with vocal cord paralysis [VCP] secondary to extra laryngeal neoplastic causes: How is it reliable?
Authors: Mosaad Basant Mohamed Raief , Abdelkader Haytham , Rabie Tahany , Abdelkawi Moustafa 
Published: February 2024

AbstractBackgroundThe main cause of voice hoarseness is vocal cord palsy (VCP) that may be induced by many diseases that could be due to local laryngeal or extra laryngeal causes, including neoplastic and non-neoplastic entities. Normal vocal cords18F-fluorodeoxyglucose (FDG) activity should be symmetric and of low grade higher than the mediastinal background uptake. Vocal cords asymmetrical FDG uptake was a well-known finding in patients with VCP. When recurrent laryngeal nerve (RLN) palsy is suspected, FDG PET and computed tomography (CT) findings can give strong evidence of diagnosis, with ability to diagnose the underlying extra laryngeal neoplastic etiology. Our aim was to assess the sensitivity and accuracy of hybrid FDG PET CT scan in diagnosis of VCP secondary to an extra laryngeal neoplastic cause.MethodsA retrospective study for 50 patients, presented with hoarseness of voice, referred from Otorhinolaryngology department to outpatient clinical oncology units, with clinically suspected extra laryngeal neoplastic causes of VCP. Left lung cancer was detected in 52% of patients which was the most frequent cause, 10% had right lung cancer, 8% had thyroid cancer, 6% had mediastinal lymphoma, 6% had metastatic mediastinal lymph nodes from breast cancer, and 6% had esophageal carcinoma.ResultsPET CT scan versus CT scan showed true positive results in (44 vs. 29 patient), true negative results in 5 patients in both scans, and false negative in (1 vs. 16 patient), with no false positive in either. Thus, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for PET CT scan versus CT scan were 98% vs. 68%, 100% for both scans, 100% for both scans, 83.3% vs. 23.8%, and 86% vs. 56%, respectively.ConclusionsFDG PET CT scan plays an important role in diagnosis of oncology-related extra laryngeal causes of VCP, with higher sensitivity, negative predictive value, and accuracy than CT scan. FDG PET CT scan should be included in the workup of VCP if extra laryngeal oncological cause is suspected.
Recommendation systems-based software requirements elicitation process—a systematic literature review
Authors: Akram Faiz , Ahmad Tanvir , Sadiq Mohd. 
Published: February 2024

AbstractRequirements elicitation is one of the fundamental sub-processes of requirements engineering which is used to find the needs of stakeholders. There are several activities in this sub-process, i.e., identification of stakeholders and their requirements, software requirements prioritization, and analysis. Recommendation systems have been intertwined with the requirements elicitation process to predict the stakeholders’ requirements based on their preferences for functional and non-functional requirements. A number of systematic literature reviews (SLRs) have been carried out in the area of requirements elicitation. These SLRs do not support the applications of the recommendation systems during the requirements elicitation process. To deal with this issue, we present an SLR on recommendation systems-based software requirements elicitation processes, from 2009 to 2022, undertaking four research questions: (a) What are the different activities of the software requirements elicitation methods? (b) What are the applications of recommendation systems in the identification of the software requirements? (c) How the recommendation systems can facilitate the identification of stakeholders in the requirements elicitation process? (d) What are the ways to automate the selection of requirements elicitation techniques? The aim of this study is to identify the research gaps in the area of recommendation systems-based requirements elicitation processes and suggest future research directions.