bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-Scale Biogeographical Shifts of Abundance of Antibiotic Resistance Genes and Marine Bacterial Communities as Their Carriers along a Trophic Gradient
Authors: Dželalija Mia , Fredotović Željana , Udiković-Kolić Nikolina , Kalinić Hrvoje , Jozić Slaven , Šamanić Ivica , Ordulj Marin , Maravić Ana 
Published: January 2024

The role of marine environments in the global spread of antibiotic resistance still remains poorly understood, leaving gaps in the One Health-based research framework. Antibiotic resistance genes (ARGs) encoding resistance to five major antibiotic classes, including sulfonamides (sul1, sul2), tetracyclines (tetA, tetB), β-lactams (blaCTX-M, blaTEM blaVIM), macrolides (ermB, mphA), aminoglycosides (aac3-2), and integrase gene (intl1) were quantified by RT-qPCR, and their distribution was investigated in relation to environmental parameters and the total bacterial community in bottom layer and surface waters of the central Adriatic (Mediterranean), over a 68 km line from the wastewater-impacted estuary to coastal and pristine open sea. Seasonal changes (higher in winter) were observed for antibiotic resistance frequency and the relative abundances of ARGs, which were generally higher in eutrophic coastal areas. In particular, intl1, followed by blaTEM and blaVIM, were strongly associated with anthropogenic influence and Gammaproteobacteria as their predominant carriers. Water column stratification and geographic location had a significant influence on ARGs distribution in the oligotrophic zone, where the bacterial community exhibited a seasonal shift from Gammaproteobacteria in winter to Marine group II in summer.
The Comet Assay as a Sustainable Method for Evaluating the Genotoxicity Caused by the Soluble Fraction Derived from Sewage Sludge on Diverse Cell Types, Including Lymphocytes, Coelomocytes and Allium cepa L. Cells
Authors: Costea Monica Adriana , Rosan Cristina Adriana , Laslo Vasile , Agud Eliza , Purcarea Cornelia , Vicas Simona Ioana 
Published: January 2024

With the expansion of urban areas, the amount of sludge produced by sewage treatment plants is increasing, raising big problems regarding the reintroduction of this sludge into nature in order to fully solve the wastewater problem. The application of sludge to agricultural surfaces or degraded land is a controversial solution since, despite the well-known benefits, sludge can, in certain cases, represent a real threat to both human health and the environment, with long-term harmful effects. The present study evaluates the potential genotoxicity of sludge using the Comet Test and three cellular bioindicators (lymphocytes, coelomocytes, and Allium cepa L.) for its quantification. To perform the tests, the soluble fraction of the sludge was used at concentrations of 25%, 50%, 75%, and 100%, as well as a negative control (H2O) and a positive control (H2O2). The Comet test indicated an increase in DNA damage among cells exposed for 4 h in the following order: coelomocytes, lymphocytes, and Allium cepa L. cells. Our results indicate that Allium cepa L. nuclei are more sensitive, with genotoxic effects being evident at concentrations as low as 25%. In coelomocytes, we recorded nuclear damage starting at a concentration of 75%. These results indicate the necessity of using multiple genotoxicity tests, combined in a test battery, to achieve a greater level of relevance. The concentration of the soluble fraction of the sludge has an inverse relationship with the auxin content in leaves and roots, suggesting varying levels of stress. The results of this study can contribute to the creation of a genotoxic profile of sewage sludge, facilitating decisions related to reducing its negative impact.
Perspectives of Perioperative Chemotherapy in the Treatment of Resectable Pancreatic Cancer
Authors: Отченаш С.В. , Шмак А.И. , Ерзинкян Ф.В. , Мартынов Е.П. , Котов А.А. , Рынейская А.Д. 
Published: January 2024

Рак поджелудочной железы (РПЖ) – системное заболевание, которое является серьезной проблемой в онкологии. Темпы роста заболеваемости РПЖ и неудовлетворительные результаты лечения позволяют прогнозировать, что в следующие десятилетия РПЖ станет второй ведущей причиной смерти среди онкологических заболеваний. В настоящее время единственный эффективный и потенциально излечивающий метод лечения резектабельного РПЖ – это хирургическое вмешательство. Протоковая аденокарцинома, составляющая 85–90% всех злокачественных новообразований поджелудочной железы, является агрессивной опухолью с высоким метастатическим потенциалом, чем обусловлен плохой прогноз для жизни у пациентов, которым выполнена радикальная операция и проведена адъювантная химиотерапия. Таким образом, оправданы разработка и внедрение таких методов лечения, как неоадъювантная и периоперационная химиотерапия. В статье представлен обзор литературных данных по лечению РПЖ, рассмотрены основные прогностические факторы опухоли, а также первые результаты разработанного метода комбинированного периоперационного лечения пациентов с резектабельным РПЖ.
Pancreatic cancer (PC) is a systemic disease that is a serious problem in oncology. The rate of increase in the incidence of PC and unsatisfactory results of treatment suggest that in the next decades, PC will become the second leading cause of death among cancers. Currently, the only effective and potentially curative treatment for resectable PC is surgery. Ductal adenocarcinoma, which accounts for 85–90% of all malignant neoplasms of the pancreas, is an aggressive tumor with a high metastatic potential, resulting in a poor prognosis for life in patients who underwent radical surgery and received adjuvant chemotherapy. Thus, the development and implementation of such methods of treatment as neoadjuvant and perioperative chemotherapy are justified. The article presents a review of literature data on the treatment of PC, the main prognostic factors of the tumor, as well as the first results of the developed method of combined perioperative treatment of patients with resectable PC.
Circulating Tumor DNA Liquid Biopsy in Patients with Non-Small Cell Lung Cancer
Authors: Короткевич П.Е. , Смирнов С.Ю. , Медведь А.В. , Пивоварчик С.Н. , Субоч Е.И. , Малькевич В.Т. , Портянко А.С. 
Published: January 2024

Рак легкого занимает лидирующие позиции в структуре онкологической заболеваемости и смертности от злокачественных новообразований в мире. Историческим «стандартом» биологического материала для проведения молекулярно-генетического тестирования является опухолевая ткань. Альтернативным минимально инвазивным методом изучения молекулярных характеристик опухоли является жидкостная биопсия. Наиболее перспективным и изученным субстратом для анализа является циркулирующая опухолевая ДНК (цоДНК) плазмы крови. Данный подход характеризуется малой инвазивностью, простотой многократного получения биоматериала и достаточно высокой концентрацией цоДНК у пациентов с распространенными формами опухолей. В статье отражены методология анализа цоДНК, возможности использования цоДНК для диагностики молекулярно-генетических нарушений, мониторинга эффективности проводимого лечения и выявления механизмов резистентности у пациентов с метастатическим немелкоклеточным раком легкого, а также оценки минимальной остаточной болезни после радикального лечения.
Lung cancer is the leading cause of cancer and cancer-related mortality worldwide. Tissue biopsy is the gold-standard diagnostic method used to confirm the diagnosis of cancer and to identify actionable targets. Liquid biopsy is a minimally invasive alternative to tissue biopsy. The most promising and studied tumor-derived material is circulating tumor DNA (ctDNA) detectable in the blood. This approach is characterized by low invasiveness, ease of repeated examination and a sufficiently high concentration of cDNA in patients with advanced disease. The methodology of ctDNA analysis, the possibility of using ctDNA for the assessment of oncogenic driver alterations, treatment response monitoring and identifying resistance mechanisms in patients with metastatic non-small cell lung cancer, as well as assessing the minimal residual disease after radical treatment, are described in the article.
The Influence of Managerial Ownership, Profitability on Company Value with Dividend Policy As Moderation
Authors: Flabiya Almayda , Sunarto Sunarto 
Published: January 2024

Abstract: This study aims to analyze and examine the effect of managerial ownership, profitability on firm value with dividend policy as moderating. The population used in this study is all mining companies that have been listed on the Indonesia Stock Exchange (IDX) in 2017-2019. The sampling method used in this research is using porpusive sampling technique. The results of this study explain that managerial ownership has a positive effect on firm value, while profitability cannot affect firm value. Dividend policy has a negative effect on firm value. Dividend policy cannot moderate the effect of managerial ownership on firm value, while dividend policy can moderate profitability on firm value.
Keywords: Dividend Policy, Firm Value, Managerial Ownership, Profitability
Optimizing Human Development: The Relevance of Hasan Langgulung's Concept of Islamic Education in the 21st Century
Authors: Fadlillah Nilna , Bakar M. Yunus Abu , Assegaf Abd. Rachman 
Published: January 2024

This article is written to explain i) the concept of fitrah and khalifah from Hasan Langgulung's perspective, ii) Hasan Langgulung's Islamic education thought, and iii) the relevance of Hasan Langgulung's Islamic education concept to the development of human potential in the 21st century. The research method used in this research is qualitative-descriptive with the type of library research, with content analysis and interpretative methods. This research is expected to be the basis for designing progressive educational policies and forming individuals who can face the dynamics of change and challenges of the 21st century. According to Hasan Langgulung, in carrying out his responsibility as caliph, humans are equipped with various potentials (fitrah, human intellect, freedom of will, spirit, qalb, nafs) that need to be developed through education. Langgulung's concept of Islamic education emphasizes the development of human potential through the optimization of human intellect, creativity, the ability to work together, continuous education, and technology in education. In the 21st century, Hasan Langgulung's Islamic concept can be applied in forming "pious human beings" who are productive innovative, and contribute positively to building a "pious society".
Keywords: Hasan Langgulung, 21st-century education, human potential, fitrah, khalifah
Improving Critical Thinking Skills of Low Academic Ability Students through TPS and PBL Integration in Biology Learning
Authors: Muhfahroyin Muhfahroyin , Rachmadiarti Fida , Mahanal Susriyati , Zubaidah Siti , Siagiyanto Bambang Eko 
Published: January 2024

Learning needs to empower the student's critical thinking because critical thinking is the core of learning to construct knowledge. The students who have knowledge from the critical thinking skills could address the contextual living problem. Therefore, the learning must be implemented as a facility for students to develop critical thinking skills for high and low academic skill students. This research aims to know the effect of Think Pair Share (TPS) and Problem Based Learning (PBL) integration to closing critical thinking between higher and lower academic skill students and to know the effect of interaction between learning method and academic ability toward the critical thinking. This research design is quasi-experimental and conducted using a pretest-posttest non-equivalent control group design conducted in Kota Metro Lampung Indonesia. Data on critical thinking skills were obtained by essay tests done by the students. The substance of the essay test includes the ability to formulate problems, argue, deduce, induce, and evaluate. Data were analyzed by using ANCOVA. The statistical calculations were measured by using SPSS version 25.0 with a significance level of 0.05. Based on the research, the conclusion can be formulated as follows; there was an effect of TPS and PBL integration towards critical thinking. There was no effect of interaction between learning method and academic ability towards critical thinking. TPS and PBL integration were effective in closing the critical thinking gaps between higher and lower academic skill students. In other words, TPS and PBL integration were effective in improving the critical thinking of low academic students in biology learning 24,63%. The researcher suggests that the teachers need to implement TPS and PBL integration in biology learning.
Effects of multirepresentation-based creative problem-solving learning model on students’ critical thinking and diet nutritional quality
Authors: Fathonah Siti , Cahyono Edy , Iswari Retno , Haryani Sri , Sarwi Sarwi , Lestari Noer , Kadarwati Sri 
Published: January 2024

This research investigated how the multirepresentation-based creative problem-solving (MBCPS) learning model could enhance students’ critical thinking skills in relation to the Nutritional Quality of Diet. The research subjects were 72 students of the Culinary Education study program in Nutrition Science, consisting of an experimental group of 36 students with MBCPS and 36 students forming a control group using conventional problem solving. The MBCPS model consists of four stages, namely problem identification, idea generation, evaluation, and validation. The students’ critical thinking skill was measured using a multiple-choice test of balanced nutrition. The Nutritional Quality of Diet is calculated from the average level of nutritional adequacy. Data analysis involved techniques using N-gain and t test. The achievement of student activities in the four stages of learning before and after the implementation of the MBCPS model experienced an increase from 52% to 68 % (p < 0.00). There was no difference in the critical thinking skills scores obtained by the experimental and the control groups before implementing the model (p=0.45). After implementing the CPSBM model, the critical thinking skills scores achieved by the experimental and control groups were 71% and 68%, which was significantly different (p = 0.00). An application of the model resulted for an increase of the critical thinking skills and the nutritional quality of diet got an N-gain of 0.47 and 0.28. The MBCPS model has prospects for development in a wider branch of knowledge in the scope of University Health Education.
Pengaruh Emotional Marketing Terhadap Proses Keputusan Pembelian Motor Vespa Di Kalangan Mahasiswa Universitas Telkom Bandung
Authors: Vandia Muhaimin  , Kristina Sisilia  
Published: January 2024

Tujuan penelitian ini ialah menganalisis pengaruh emotional marketing terhadap proses keputusan pembelian motor vespa di kalangan mahasiswa Universitas Telkom Bandung. Penelitian kuantitatif digunakan pada penelitian ini. Populasi dalam penelitian ini adalah mahasiswa Universitas Telkom yang memiliki dan menggunakan motor vespa dimana jumlah dari pengguna motor vespa ini belum diketahui. Jumlah sampel sebesar 239 orang mahasiswa. Penelitian ini menggunakan metode purposive sampling. Teknik Analisis Data yaitu analisis Deskriptif, dilakukan dengan menggunakan persentase yang menunjukkan tingkat persepsi responden terhadap pernyataan-pernyataan yang dimuat di dalam kuesioner. Hasil penelitian ini ialah Emotional marketing yang dirasakan oleh responden sudah pada kategori tinggi, dalam arti Vespa memiliki Langkah-langkah yang tepat dalam memasarkan produknya, sehingga calon konsumen ataupun konsumennya merasa memiliki keinginan secara emosional untuk memiliki Vespa. Proses keputusan pembelian produk Vespa berada pada kategori tinggi, sehingga dapat disimpulkan bahwa responden sebetulnya sudah memiliki proses keputusan pembelian yang dilakukan dengan baik sebelum memutuskan untuk membeli Vespa.Variabel emotional marketing memiliki hubungan yang kuat dengan pembentukan proses keputusan pembelian
Al-Musykilât wa Al-Hulûl fî Dirâsah Ta'allumi Al-Lughah Al-Arabiyyah li Shaf Al-Awwal bi Ma'had Ta'mîr Al-Islâmi li Al-Tarbiyah Al-Islâmiyyah Surakarta
Authors: Rahmawati Sugma , Hafida  , Qosim Muhammad Nanang , Kholiq Hasan Moh. Abdul 
Published: January 2024

يواجه تعليم أية لغة أجنبية عدة مشاكل تقتضي التفكير و الإهتمام بها حتي يتمكن من إيجاد حلولها. و تنقسم مشكلات تعليم الللغة العربية إلى المشاكل الللغوية و غير اللغوية. فاللغوية تطهر في الأصوات و المفرداتو القولعد النحوية و الصرفية و اللتركيب: أما غير اللغوية فترتبط بدوافع الطالبات إلى تعليمها و الوسائل لتعليمية و كفاءة المدرس و طرف التدريس و فرصة الدراسة و البيئة اللغوية وغيرها. وتختلف صعوبات تعلم اللغة العربية تبعا لسن الدراس و البيئة التي فيها أثناء تعلمه اللغة. و هذه المقالة تكشف عن مشكلات تعليم اللغة العربية لدى الطالبات بمعهد تعمير الأسلام للتربية الإسلامية سوراكرتا و طرف علاجها التي ينبغي تطبيقها على المدرين المؤهيلن
There are some factors influencing teaching and learning of foreign language arabic, for example lunguistic factors, sunh as phonology, grammatical, morphology, and vocabulary. If non linguistic factors influences teaching and learning arabic, for example ,teaching aids,teaching method, age and environment teaching method in arabic claccroom for 1KMI in one of the important factor. This article discusses how linguistic factor and non linguistic factor influenced arabian clasroom in ta’mirul islam boarding school surakarta.
Pendidikan bahasa arab di Indonesia seringkali menghadapi problem lingusitik dan non linguistik yang harus segera dituntaskan. Problem linguistik, seperti fonotik, morfologi, dan struktur. Sedangkan problem non lingusitik, antara lain; motivasi belajar, sarana belajar, metode pengajaran, waktu belajar, dan lingkungan pembelajaran. Persoalan pembelajaran bahasa sangat bervariasi sesuai dengan usia pelajar dan lingkungan tempat belajar. Artikel ini mengungkap problematika pengajaran bahasa Arab di Pondok Pesantren Ta’mirul Islam sekaligus bagaimana cara mengatasinya. Jadi peneliti akan meneliti apa penyebab santriwati kelas 1KMI belum bisa menggunakan bahasa arab, dan metode apa yang harus disampaikan ke anak supaya anak tersebut dapat menerima bahasa arab dengan baik.
Al-Istifâdah min Al-Al'âb Al-Lughawiyah li Ta'lîm Al-Lughah Al-'Arabiyyah li Al-Sâsâkiyyîn Al-Mubtadi-în bi Istikhdâm Al-Kalimât Al-Sâsâkiyyah Dzat Ashl 'Arabiy fî Qômus Al-Lughah Al-Sâsâkiyyah (Nazir Toir)
Authors: Ardiansyah  , Kosim Nanang 
Published: January 2024

تهدف هذه الدراسة إلى اكتشاف الكلمات الساساكية ذات أصل عربي في قاموس اللغة الساساكية (nazir toir) وهذا المبدأ ينبني على أن بين اللغتين الساساكية و العربية وهي لغة القرآن الكريم علاقة وتيدة منذ دخول الإسلام في جزيرة لومبوك. وتهدف هذه الدراسة إلى كيفية تصميم ألعاب لغوية لتعليم اللغة العربية للساساكيين المبتدئين باستخدام الكلمات الساساكية ذات أصل عربي.و اعتمدت هذه الدراسة على المنهج الوصفي التحليلي الذي يصف وصفا دقيقا لموضوع الدراسة وذلك من خلال تحليل الكلمات الساساكية ذات أصل عربي بالعتماد على القاموس الساساكي والعربي، وتصميمها في الألعاب اللغوية.وأثبتت هذه الدراسة إمكانية الاستفادة من الكلمات الساساكية ذات أصل عربي في تعليم اللغة العربية للومبوكيين من خلال تصميم ألعاب لغوية.
This study aimed to express an absorption words of Sasak language derived from Arabic language in the Nazir book. This principle is based on the fact that between Sasak language and Arabic, language of the qur'an, which has a reltionship and affiliation since the introduction of Islam in Lombok island. This study also aimed how to design a language game to teach Arabic language for the beginners from Sasak tribes by using Sasak words derived from Arabic. This study used descriptive analytic approach, which described an accurate description about the subject of the research. Through analysis the words of Sasak language derived from Arabic, based on Sasak and Arabic dictionary and there are sentences designed into language game. This study showed the exsistence of Sasak words derived from Arabic in Sasak dictionary (Nazir book) from the letter A-R as an example and the total reaches one hundred and fourty five words. This study concluded that there is a change of Arabic words that entered to Sasak Language and the sentences divided into four classes
Kata Cinta dan Padanannya Dalam Novel Laila Majnun Karya Nizami
Authors: Marup  
Published: January 2024

Penelitian ini menganalisis makna cinta dalam novel "Laila Majnun" karya Nizami dengan tiga fokus utama: 1) Identifikasi kata-kata yang merujuk pada cinta dalam novel, 2) Menentukan kolokasi makna cinta, dan 3) Menganalisis tingkatan cinta. Metode deskriptif analisis digunakan dengan mengumpulkan data dari novel tersebut. Data tersebut kemudian disortir dengan bantuan kamus untuk mengidentifikasi kata-kata yang terkait dengan cinta. Pendekatan semantik digunakan untuk memahami hubungan antara kata-kata tersebut. Hasil penelitian menunjukkan bahwa terdapat sejumlah kosakata yang menggambarkan cinta dalam novel, termasuk kata-kata seperti "الحب، الهوى، العشق، الغرام، الشوق، الوجد، الجوى." Analisis juga mengungkapkan tingkatan cinta, yang dimulai dari "الهوى" dan berakhir dengan "الغرام" sebagai tingkatan tertinggi, yang menggambarkan cinta yang tetap dan tak tergantikan.
This research analyzes the meaning of love in the novel "Laila Majnun" by Nizami with three main focuses: 1) Identifying words that refer to love in the novel, 2) Determining the collocations of the meaning of love, and 3) Analyzing the levels of love. A descriptive analysis method was used by collecting data from the novel. The data were then sorted with the help of a dictionary to identify words related to love. A semantic approach was employed to understand the relationships between these words. The research results show that there is a significant vocabulary that describes love in the novel, including words like "الحب، الهوى، العشق، الغرام، الشوق، الوجد، الجوى." The analysis also reveals different levels of love, starting from "الهوى" and culminating in "الغرام" as the highest level, representing enduring and irreplaceable love.