bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advantages of single-site laparoscopic orchiopexy for palpable undescended testes in children: a prospective comparison study
Authors: Yang Zhilin , He Yingying , Chen Pengyu , Zhang Tiejun , Ke Zhicong , Sun Fenghao , Zhou Guanglun , Zhao Weiguang , Li Shoulin 
Published: January 2024

Abstract
Purpose
To evaluate the feasibility of single-site laparoscopic orchiopexy for palpable undescended testes in children.

Methods
We prospectively studied patients with undescended testes between July 2021 and June 2022. In total, 223 patients were included in our study: 105 underwent single-site laparoscopic orchiopexy and 118 underwent conventional laparoscopic orchiopexy. During single-site laparoscopic orchiopexy, 3 ports were inserted within the umbilicus.

Results
No differences were observed between the groups in terms of age and laterality. For unilateral undescended testes, the operating time was longer in the single site group than in the conventional group at the early stages (55.31 ± 12.04 min vs. 48.14 ± 14.39 min, P = 0.007), but it was similar to the conventional group at the later stages (48.82 ± 13.49 min vs. 48.14 ± 14.39 min, P = 0.78). Testicular ascent occurred in one patient from each group. There was no significant difference in the success rate between the single-site group and the conventional group (99.0% vs. 99.2%, P = 0.93). In the single-site group, no visible abdominal scarring was observed, while in the conventional group, there were two noticeable scars on the abdomen.

Conclusion
Single-site laparoscopic orchiopexy offers superior cosmetic results and comparable success rates compared to conventional laparoscopic orchiopexy for palpable undescended testes.
Bayesian joint longitudinal models for assessing the exploitation rates of sardine stock in the Mediterranean Sea
Authors: Calvo Gabriel , Armero Carmen , Spezia Luigi , Pennino Maria Grazia 
Published: January 2024

AbstractThe European sardine is a pelagic species of great ecological importance for the conservation of the Mediterranean Sea as well as economic importance for the Mediterranean countries. Its fishing has suffered a significant decline in recent years due to various economic, cultural and ecological reasons. This paper focuses on the evolution of sardine catches in the Mediterranean Sea from 1985 to 2018 according to the fishing Mediterranean country and the type of fishing practised, artisanal and industrial. We propose three Bayesian longitudinal linear mixed models to assess differences in the temporal evolution of artisanal and industrial fisheries between and within countries. Overall results confirm that Mediterranean fishery time series are highly diverse along their dynamics and this heterogeneity is persistent throughout the time. Furthermore, our results highlight a positive correlation between artisanal and industrial fishing. Finally, the study observes a consistent decreasing time trend in the quantity of fish landings. Although the causes of this feature could be also linked to economic motivations (such as a reduction in demand or the reorientation of fleets towards more commercially beneficial species), it may indicate a potential risk to the stock of this species in the Mediterranean Sea.
Sensitivity analysis in the wavelet domain: a comparison study
Authors: Chiogna Gabriele , Marcolini Giorgia , Engel Michael , Wohlmuth Barbara 
Published: January 2024

AbstractSensitivity analysis plays a pivotal role for the development and calibration of hydrological models, since they are often affected by equifinality. Despite a lot of effort has been placed for the development of effective sensitivity analysis methods, hydrological models remain over parametrized. We take advantage of the evidence that hydrological processes can be described as the superposition of effects occurring at different temporal scales (e.g., seasonal precipitation patterns, seasonal and daily snow and glacier melt, seasonal, daily and sub-daily water management operations) to develop a new framework to perform sensitivity analysis. We apply discrete and continuous wavelet transforms to disentangle hydrological signals occurring at different temporal scales and we take advantage of the different information stored at different temporal scales of the wavelet spectrum to perform a scale-dependent sensitivity analysis. This approach aims to increase the number of identifiable model parameters in comparison to standard sensitivity analysis performed in the time domain. As an exemplary problem, we apply the methodology to synthetic data describing surface water-groundwater interaction in rivers affected by hydropeaking (i.e., sudden fluctuations in the river stage due to hydropower production). The method could be applied also to other models displaying the superposition of processes with different intensities at different temporal scales such as ocean tide propagation in aquifers as well as snow and glacier melt models. The results indicate that considering multiple temporal scales allows us to increase the number of parameters that can be identified and hence calibrated with only a little increase in the computational effort.
The first steps in the development of a cancer-specific patient-reported experience measure item bank (PREM-item bank): towards dynamic evaluation of experiences
Authors: van Hof Kira S. , Dulfer Karolijn , Sewnaik Aniel , Baatenburg de Jong Robert J. , Offerman Marinella P. J. 
Published: January 2024

Abstract
Objective
Since the implementation of value-based healthcare, there has been a growing emphasis on utilizing patient-reported experience measures (PREMs) to enhance the quality of care. However, the current PREMs are primarily generic and static, whereas healthcare is constantly evolving and encompasses a wide variety of aspects that impact care quality. To continuously improve care requires a dynamic PREM. The aim of this study was to propose an item bank for the establishment of a dynamic and care-specific patient-reported evaluation.

Methods
In co-creation with patients, a mixed methods study was conducted involving: (1) an explorative review of the literature, (2) a focus group analysis with (ex-)patients, (3) qualitative analyses to formulate themes, and (4) a quantitative selection of items by patients and experts through prioritization.

Results
Eight existing PREMs were evaluated. After removing duplicates, 141 items were identified. Through qualitative analyses of the focus group in which the patient journey was discussed, eight themes were formulated: “Organization of healthcare,” “Competence of healthcare professionals,” “Communication,” “Information & services,” “Patient empowerment,” “Continuity & informal care,” “Environment,” and “Technology.” Seven patients and eleven professionals were asked to prioritize what they considered the most important items. From this, an item bank with 76 items was proposed.

Conclusion
In collaboration with patients and healthcare professionals, we have proposed a PREM-item bank to evaluate the experiences of patients’ receiving cancer care in an outpatient clinic. This item bank is the first step to dynamically assess the quality of cancer care provided in an outpatient setting.
Postpartum symptoms of anxiety, depression and stress: differential relationships to women’s cortisol profiles
Authors: Weiss Sandra J. , Xu Ling 
Published: January 2024

Abstract
Purpose
Women are at high risk of stress, anxiety, and depression during the postpartum but the ways in which these different types of psychological distress are related to cortisol regulation is not clear. We examined the distinct association of each type of distress with women’s average cortisol level, cortisol awakening response (CAR), cortisol decline across the day (diurnal slope), and overall amount of cortisol secretion across the day (AUCG).

Methods
At 6 months postpartum, a diverse group of 58 women completed measures of depression, anxiety, perceived stress, and life stressors. Each woman provided 4 salivary samples for cortisol assay from waking to bedtime on each of 2 consecutive days. Linear regressions were used to examine associations of stress, anxiety and depression to each of the 4 cortisol measures, controlling for number of stressful life events.

Results
Depressive symptoms were associated with less of a rise in the CAR (β = -.46, p = 0.01), steeper diurnal slope (β = .51, p = 0.006), and higher average cortisol level (β = .42, p = .01). Women who met the clinical cutoff for an anxiety disorder had lower overall cortisol output (β = -.29, p = 0.03). Stress was not related to any cortisol metric.

Conclusions
Findings suggest that stress is less associated with cortisol alterations in the postpartum than are more severe types of psychological distress. Anxiety and depression may have distinct and opposite profiles of cortisol dysregulation. Results indicate that mental health assessment is critical even in the later postpartum so that interventions can be initiated to reduce emotional suffering and the risk of impaired cortisol regulation.
Assessing the validity of VR as a training tool for medical students
Authors: Pedram Shiva , Kennedy Grace , Sanzone Sal 
Published: January 2024

AbstractThe advances in Virtual Reality technologies, increased availability and reducing hardware costs have diminished many of the early challenges in the adoption of VR. However, a commonly identified gap in immersive Virtual Reality-Head Mounded Display (VR-HMD) training for medical education is the confidence in the long-term validity of the applications, in particular, the acceleration of the learning curve efficacy of learning outcomes over time and actual skills translation into real environments. Research shows a wide range of ad hoc applications, with superficial evaluations often conducted by technology vendors, based on assumed environments and tasks, envisaged (as opposed to actual) users and effectiveness of learning outcomes underpinned with little or no research focusing on a requirements-driven validation approach. This presents decision-making challenges for those seeking to adopt, implement and embed such systems in teaching practice. The current paper aims to (i) determine whether medical VR training improves the skill acquisition of training candidates, (ii) determine the factors affecting the acquisition of skills and (iii) validate the VR-based training using requirement-driven approach. In this paper, we used within- and between-subject design approaches to assess the validity of VR-based surgical training platform developed by Vantari VR against requirements which have been identified to have impact on learning processes and outcomes in VR-based training. First, study and control groups were compared based on their level of skill acquisitions. Then, by tailoring a requirements framework, the system was validated against the appropriate requirements. In total, 74 out of 109 requirements were investigated and evaluated against survey, observer and stakeholder workshop data. The training scenario covered the topic of Arterial Blood Gas (ABG) collection for second-year university medical students. In total 44 students volunteered to participate in this study, having been randomly assigned to either the study or control group. Students exposed to VR training (the study group) outperformed the control group in practical clinical skills training tasks and also adhered to better safety and hygiene practices. The study group also had a greater procedural completion rate over the control group. Students showed increased self-efficacy and knowledge scores immediately post-VR training. Prior ABG training did not impact on VR training outcomes. Low levels of simulation sickness, physical strain and stress, coupled with high levels of enjoyability, engagement, presence and fidelity were identified as factors affecting the overall training experience. In terms of learning, high scores were recorded for active learning, cognitive benefit and reflective thinking. Lastly, by validating the system against 74 system requirements, the study found a user acceptance level of 75%. This enabled the identification of weaknesses of the current system and possible future directions.
Detection of hypoplastic left heart syndrome anatomy from cardiovascular magnetic resonance images using machine learning
Authors: Gabbert Dominik Daniel , Petersen Lennart , Burleigh Abigail , Grazioli Simona Boroni , Krupickova Sylvia , Koch Reinhard , Uebing Anselm Sebastian , Santarossa Monty , Voges Inga 
Published: January 2024

Abstract
Objective
The prospect of being able to gain relevant information from cardiovascular magnetic resonance (CMR) image analysis automatically opens up new potential to assist the evaluating physician. For machine-learning-based classification of complex congenital heart disease, only few studies have used CMR.

Materials and methods
This study presents a tailor-made neural network architecture for detection of 7 distinctive anatomic landmarks in CMR images of patients with hypoplastic left heart syndrome (HLHS) in Fontan circulation or healthy controls and demonstrates the potential of the spatial arrangement of the landmarks to identify HLHS. The method was applied to the axial SSFP CMR scans of 46 patients with HLHS and 33 healthy controls.

Results
The displacement between predicted and annotated landmark had a standard deviation of 8–17 mm and was larger than the interobserver variability by a factor of 1.1–2.0. A high overall classification accuracy of 98.7% was achieved.

Discussion
Decoupling the identification of clinically meaningful anatomic landmarks from the actual classification improved transparency of classification results. Information from such automated analysis could be used to quickly jump to anatomic positions and guide the physician more efficiently through the analysis depending on the detected condition, which may ultimately improve work flow and save analysis time.
Exploring the potential of federated learning in mental health research: a systematic literature review
Authors: Khalil Samar Samir , Tawfik Noha S. , Spruit Marco 
Published: January 2024

AbstractThe rapid advancement of technology has created new opportunities to improve the accuracy and efficiency of medical diagnoses, treatments, and overall patient care in several medical domains, including mental health. One promising novel approach is federated learning, a machine learning approach that allows multiple devices to train a shared model without exchanging raw data. Instead of centralizing the data in one location, each device or machine holds a portion of the data and collaborates with other devices to update the shared model. In this way, federated learning enables training on more extensive and diverse datasets than would be possible with centralized training while preserving the privacy and security of individual data. In the mental health domain, federated learning has the potential to improve mental disorders’ detection, diagnosis, and treatment. By pooling data from multiple sources while maintaining patient privacy by keeping data secure and ensuring that they are not used for unauthorized purposes. This literature survey reviews recent studies that have exploited federated learning in the psychiatric domain, covering multiple data resources and different machine-learning techniques. Furthermore, we formulate the gap in the current methodologies and propose new research directions.
Early generation clonal selection of sweetpotato (Ipomoea batatas (L.) Lam) using an accelerated breeding scheme
Authors: Naidoo Sónia I. M. , Laurie Sunette M. , Booyse Mardé , Shimelis Hussein , Laing Mark D. , Mphela Whelma M. 
Published: January 2024

AbstractThe breeding stages of a clonally propagated crop entails several steps and can take more than five years from hybridisation till cultivar release. The Accelerated Breeding Scheme (ABS) in sweetpotato relies on the use of multiple locations at the early breeding stages to reduce the years required for field evaluation. The aim of the study was to select the best progenies based on the ABS in sweetpotato towards the development of genotypes that combine high protein content with other important agronomic traits. Botanical seeds were generated from crosses between two diverse sets of parents, crossed using a North Carolina II design. F1-progenies (n = 363) were planted in a lattice design at three distinct locations during the 2017/18 planting season. Parameters recorded included pest and disease infestation, storage root traits and yield components, root protein content and nutrient related traits. Nutrient content was determined by near-infrared spectrometry. Analysis of variance and multiple t-distribution test and best test grouping were performed. There were significant differences (p < 0.001) among the genotypes for total number of roots, total root yield, marketable number of roots and marketable yield. The severity of Alternaria blight was significantly higher at Jozini. Forty progenies were selected (12.8% selection pressure) based on agronomic performance. Using the nutrient content results, four promising orange-fleshed clones (NC12-9, NC53-11, NC55-8, NC55-2) and one cream-fleshed clone (NC51-1) were identified with high storage root protein, iron and zinc contents. NC51-1 and NC55-2 produce promising storage root yields. The ABS approach is resource-demanding in the first phase but advances progenies rapidly to the subsequent breeding phases for cultivar release.
Behavioral Phenotypes and Comorbidity in 3q29 Deletion Syndrome: Results from the 3q29 Registry
Authors: Pollak Rebecca M. , Mortillo Michael , Murphy Melissa M. , Mulle Jennifer G. 
Published: January 2024

Abstract
3q29 deletion syndrome (3q29del) is associated with a significantly increased risk for neurodevelopmental and neuropsychiatric disorders. However, the full spectrum of behavioral phenotypes associated with 3q29del is still evolving. Individuals with 3q29del (n = 96, 60.42% male) or their guardian completed the Achenbach Child or Adult Behavior Checklist (CBCL/ABCL) via the online 3q29 registry (3q29deletion.org). Typically developing controls (n = 57, 49.12% male) were ascertained as a comparison group. We analyzed mean performance on the CBCL/ABCL for individuals with 3q29del and controls across composite, DSM-keyed, and developmental scales; and the relationship between CBCL/ABCL performance and clinical and developmental phenotypes for individuals with 3q29del. Individuals with 3q29del showed significantly elevated behavioral and developmental impairment relative to controls across CBCL/ABCL domains. A substantial proportion of study participants with 3q29del scored in the Borderline or Clinical range for composite and DSM-keyed scales, indicating significant behavioral problems that may require clinical evaluation. We found that the preschool CBCL DSM-keyed autism spectrum problems scale is a potential screening tool for autism spectrum disorder (ASD) for individuals with 3q29del; CBCL/ABCL DSM-keyed scales were not accurate screeners for anxiety disorders or attention-deficit/hyperactivity disorder (ADHD) in our study sample. We identified a high degree of psychiatric comorbidity in individuals with 3q29del, with 60.42% (n = 58) of individuals with 3q29del scoring in the Borderline or Clinical range on two or more DSM-keyed CBCL/ABCL scales. Finally, we found that the degree of developmental delay in participants with 3q29del does not explain the increased behavioral problems observed on the CBCL/ABCL. The CBCL/ABCL can be used as screening tools in populations such as 3q29del, even in the presence of substantial psychiatric comorbidity. These results expand our understanding of the phenotypic spectrum of 3q29del and demonstrate an effective method for recruiting and phenotyping a large sample of individuals with a rare genetic disorder.
Towards scalability for resource reconfiguration in robotic assembly line balancing problems using a modified genetic algorithm
Authors: Albus Marcel , Hornek Timothée , Kraus Werner , Huber Marco F. 
Published: January 2024

Abstract
Assembly lines are still one of the most used manufacturing systems in modern-day production. Most research affects the building of new lines and, less frequently, the reconfiguration of existing lines. However, the first is insufficient to meet the reconfigurable production paradigm required by volatile market demands. Consequent reconfiguration of resources by production requests affects companies’ competitiveness. This paper introduces a problem-specific genetic algorithm for optimizing the reconfiguration of a Robotic Assembly Line Balancing Problem with Task Types, including additional company constraints. First, we present the greenfield and brownfield optimization objectives, then a mathematical problem formulation and the composition of the genetic algorithm. We evaluate our model against an Integer Programming baseline on a reconfiguration dataset with multiple equipment alternatives. The results demonstrate the capabilities of the genetic algorithm for the greenfield case and showcase the possibilities in the brownfield case. With a scalability improvement through computation time decrease of up to

$$\sim $$

∼

2.75

$$\times $$

×

, reduced number of equipment and workstations, but worse objective values, the genetic algorithm holds the potential for reconfiguring assembly lines. However, the genetic algorithm has to be further optimized for the reconfiguration to leverage its full potential.
Let’s Talk About Sex! Perspectives from People with Intellectual and Developmental Disabilities and Caregivers in Residential Institutions in Greenland
Authors: Nørtoft Kamilla , Rubin Sofie Emma 
Published: January 2024

AbstractThis study explores how attitudes toward talking about sex and sexual matters influence practices regarding sexuality, sexual rights, and sexual abuse in residential institutions for people with disabilities in Greenland. 16 residents aged 17–62 and 29 managers and staff from 8 residential institutions have been interviewed about the ways sexual needs and rights are treated and discussed as well as how sexual harassment and violations are prevented or handled. The results of the study show that there are great variations between the residential institutions regarding meeting residents’ sexual needs, talking about sex, sex education, and knowledge of rules and policies in the area. While some managers and staff are quite comfortable talking to residents and each other about sex, boundaries, and the body, others find it extremely difficult and some even reject the thought of sex as a relevant topic for the residents. Regardless of the level of openness about sexual matters in the residential institutions, staff and managers express a need for more sex education with a focus on how they can best help, guide, and protect residents, but guidance about sex is much more available for residents when staff feel comfortable talking about sex. Sexual violations and illegal sexual contact might take place in residential institutions regardless of the local practices regarding sex and sex education. However, openness about sexual matters might help detect overstepped sexual boundaries and stop sexual harassment and violations earlier.