bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution of different classes of CSF3R mutations and co-mutational pattern in 360 myeloid neoplasia
Authors: Maffei Rossana , Paolini Ambra , Conte Benedetta , Riva Giovanni , Nasillo Vincenzo , Cretì Federica , Martinelli Silvia , Giacobbi Francesca , Corradini Giorgia , Pilato Flora , Bernabei Daniela , Lancellotti Cesare , Debbia Giulia , Morselli Monica , Potenza Leonardo , Giusti Davide , Colaci Elisabetta , Bettelli Francesca , Bresciani Paola , Cuoghi Angela , Gilioli Andrea , Messerotti Andrea , Pioli Valeria , Maccaferri Monica , Leonardi Giovanna , Manfredini Rossella , Marasca Roberto , Eccher Albino , Luppi Mario , Forghieri Fabio , Candoni Anna , Tagliafico Enrico 
Published: February 2025

Abstract
The colony-stimulating factor 3 receptor (CSF3R) plays an essential role in differentiation, growth, and survival of granulocytes. Driver mutations in CSF3R gene represent a diagnostic marker of chronic neutrophilic leukemia (CNL). Less commonly, these mutations are observed in other myeloid neoplasms but their pathogenetic and prognostic role is still unclear. Here, we analyzed a large cohort of myeloid neoplasms to evaluate the incidence of CSF3R mutations and co-mutational profile. Mutational analysis was performed using targeted NGS myeloid panel in a consecutive cohort of 360 patients with myeloid neoplasms. Mutations in CSF3R were identified in 20/360 (5.6%) cases. A CSF3R gene mutation was present in 13/179 AML cases (7.3%), in 2/27 (7.4%) CMML cases, in 1/94 (1.1%) MDS cases and in 4/60 (6.7%) other myeloid neoplasms. The frequencies of patients with CSF3R mutations lowered to 2.8% in all cases and 3.4% in AML, excluding cases with variants of uncertain significance (VUS). A total of 23 mutations of CSF3R gene were detected, half localized in the extracellular domain, 5 in the transmembrane region (type I) and 6 mutations in the cytoplasmic domain (type II). In AML, CSF3R mutations were more frequent in patients harboring CBF alterations (25.0%) and CEBPA mutations (11.8%). Two cases with AML harboring pathogenic CSF3R variants were primary refractory to induction therapy. CMML cases with T618I variant showed a myeloproliferative phenotype. Overall, our findings support the notion that CSF3R variants, particularly type I and II pathogenic mutations, may modulate the phenotypic features of leukemic cells in myeloid neoplasia.
Menstrual and sexual functions in female patients after sleeve gastrectomy due to obesity: obesity and sexual function
Authors: Şimşek Hayal Uzelli , Varol Ece Nur , Güler Sertaç Ata , Şimşek Turgay , Şahin Enes , Cantürk Nuh Zafer 
Published: February 2025

Abstract

Purpose
Obesity is a systemic condition that is increasingly common. Obesity negatively affects sexual function and menstrual regularity. Therefore, losing excess weight is important for women's sexual and menstrual health.

Methods
The change in body mass index (BMI) and and excess weight loss (EWL) of sexually active female patients who underwent laparoscopic sleeve gastrectomy (LSG) were evaluated by a general surgeon. The preoperative and postoperative periods were compared by a gynecologist using the survey method menstrual patterns, dysmenorrhea complaints, if any, and sexual function with the Female Sexual Function Scale (FSFI).

Results
The study included 55 patients with a mean ± standard deviation BMI on the day of the operation of 45.32 ± 5.82 kg/m2. In the first postoperative year, the mean BMI significantly reduced to 27.88 ± 1.99 (p < 0.001). The mean percentage of EWL at the end of 1 year was 73.09 ± 19.74 after LSG. The median (range) preoperative FSFI score of the patients was 26.30 (22.70–27.70). One year after LSG, the median FSFI score significantly improved to 34.50 (30.20–35.30) (p < 0.001). Compared to the period before surgery, the frequency of sexual intercourse increased from two-to-three times a week (p < 0.001).

Conclusion
Women's sexual desires are a fundamental human right and contribute to female well-being. Thus, it is important to treat sexual dysfunction. The results of the present study demonstrate a significant improvement in sexual dysfunctions after LSG. LSG was an effective procedure that may be recommended to obese women with sexual dysfunction and menstrual problems.

Graphical abstract
Barriers and Facilitators to implementation of the Free Water Protocol in the Acute Stroke Unit Setting: A Mixed Methods Systematic Review
Authors: Eltringham Sabrina A. , Martindale Nicola , Lightbody Elizabeth , Pownall Sue , Booth Andrew , Smith Craig J. 
Published: February 2025

Abstract
Free water protocols (FWP) give patients at risk of aspiration the option to drink water between meals. Evidence is lacking about their use in acute stroke care. This systematic review evaluated the literature about barriers and facilitators to FWP implementation in acute stroke unit settings. Electronic databases and grey literature sources were systematically searched, eligible studies were critically appraised, and data extracted and mapped onto the Consolidated Framework for Implementation Research (CFIR). The results are presented in a narrative synthesis. Five studies were identified for inclusion: Two qualitative studies, 1 mixed method study, 1 randomised controlled trial and 1 pilot cohort study. Barriers and facilitators to implementation were identified across the 5 CFIR domains. Key barriers were a lack of evidence base and a standard protocol, trying to adapt and deliver a protocol designed for a different setting, complexity of patient selection and FWP design, culture of risk aversion, nursing staff availability and skills to deliver the FWP, and a greater use of agency nurses and transient workforce. Key facilitators were the existence of national guidance for research into its use, implementation of oral care protocols prior to FWP implementation, the unique characteristics of the acute stroke setting, leadership and modelling by senior clinicians, interdisciplinary working and accountability for roles and responsibilities for each discipline, regular communication and ongoing education, and involving patients in decision making and implementation. The findings of this review will guide the data collection of a feasibility study of the FWP in acute stroke.
Cervical pedicle screw placement with patient-specific 3D-printed guides: accuracy and safety in a clinical experience
Authors: Marengo Nicola , Colonna Stefano , Bue Enrico Lo , Pesaresi Alessandro , Saaid Ayoub , Allevi Mario , Ajello Marco , Mahieu Geert , Garbossa Diego , Cofano Fabio 
Published: February 2025

Abstract

Purpose
Cervical pedicle screw (CPS) instrumentation offers significant biomechanical advantages compared to lateral mass or transarticular fixation. Nonetheless, malpositioning complications constitute a relevant concern. Customized patient-specific 3D-printed templates have been developed to improve CPS placement accuracy and safety. The aim of this study is to present our experience with this surgical technique and its accuracy and safety in a clinical setting.

Methods
This single-center retrospective observational study of prospectively collected data included patients undergoing CPS fixation surgery using a patient-specific 3D template guide system. All patients underwent a 3D-volumetric high-resolution CT scan of the cervical spine for preoperative surgical planning. Postoperative CT scans were used to evaluate pedicle perforation, CPS trajectories, and deviations between the planned and the actual screw position.

Results
A total of 115 CPS were implanted in 25 patients, with 107 (93.1%) of the screws completely placed inside the pedicle. Cortical breach within 2 mm was observed in 8 (6.9%) cases, with no cases of more severe pedicle infractions or perioperative neurovascular complication. No differences of CPS accuracies were found between each metameric fusion level, and between monolateral or bilateral templates. Mean total deviations were 0.75 mm vertically and 0.51 mm horizontally at the screw entry point, and 0.72 mm vertically and horizontally at the narrowest pedicle point. Mean total sagittal and transverse angular deviations were 2.94° and 3.04°, respectively.

Conclusion
Cervical pedicle screw placement using patient-specific guides is safe and accurate, supporting the feasibility of this technique in posterior cervical spine fusion surgery.
Anchoring autonomy: understanding seafarers’ interaction with energy efficiency decision support systems for route planning and the role of basic psychological needs
Authors: Zoubir Mourad , Schwarz Benjamin , Heidinger Jan , Gruner Marthe , Jetter Hans-Christian , Franke Thomas 
Published: February 2025

Abstract
Onboard Decision Support Systems (DSS) for energy-efficient maritime route planning are key for global carbon reduction and sustainable transportation goals. Research indicates seafarers’ fuel reduction behaviors are hindered by goal conflicts and workload, affecting motivation and efficient use of automated systems. We studied seafarers’ (N = 22) interactions with a DSS in a high-fidelity bridge simulator, assessing Usability, User Experience, Workload, Basic Psychological Need (BPN) fulfillment, and conducted interviews. Positive system evaluations, particularly hedonic User Experience, contrasted with perceived reduced autonomy using the DSS. Seafarers often requested autonomy-enhancing features (e.g., route editing). Our findings underline the importance of BPNs, especially autonomy, in human-centered technology for maritime transportation, contributing to environmental and efficiency goals.
Real-world effectiveness and retention rate of upadacitinib in patients with rheumatoid arthritis: results from a multicentre study
Authors: Baldi Caterina , Gentileschi Stefano , Li Gobbi Francesca , Cazzato Massimiliano , Delle Sedie Andrea , Gaggiano Carla , D’Ignazio Emilio , Lepri Gemma , De Lorenzo Chiara , Nannini Carlotta , Niccoli Laura , Panaccione Anna , Di Cato Luca , Di Matteo Andrea , Picchianti-Diamanti Andrea , Guiducci Serena , Frediani Bruno , Benucci Maurizio 
Published: February 2025

Abstract
This study evaluates upadacitinib (UPA) effectiveness and drug retention rate (DRR) in patients with rheumatoid arthritis (RA). Multicentre prospective observational study. Consecutive patients with RA receiving UPA were evaluated at 0, 3, 6, 12, 18, and 24 months of treatment. Key outcomes included UPA DRR and changes in clinical and serological measures over time. The study included 215 patients (72.6% female sex, mean age 60.1 ± 11.7 years). The DRR of UPA was 91.6% (95% CI 88.0–95.4%) at 6 months, 84.6% (95% CI 79.8–89.7%) at 12 months, 80.3% (95% CI 75.0–86.0%) at 18 months and 80% (95% CI 75.0–86.0%) at 24 months. UPA DRR was similar between monotherapy and methotrexate combination (p = 0.47), and across different treatment lines (p = 0.58). A statistically significant improvement from baseline was observed over 24 months considering erythrocyte sedimentation rate, C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), Disease Activity Score (DAS)28-CRP, Physician’s (Ph) and Patient’s (Pt) Global Assessment (GA), Visual Analogue Scale (VAS) Pain, Simplified and Clinical Disease Activity Index (SDAI and CDAI) (p < 0.00 for all of them). Patients discontinuing UPA were more likely to be male (p = 0.02), with a longer disease duration (p = 0.03), higher baseline values of VAS Pain (p < 0.00), PtGA (p < 0.00), PhGA (p < 0.00), CDAI (p < 0.00), SDAI (p < 0.00) and corticosteroid dosage (p = 0.04). This study confirms UPA effectiveness in managing RA in the real-world practice, demonstrating sustained drug retention and improvements in clinical and laboratory measures over time. Also, UPA could be a valuable option for patients with multi-refractory RA and when monotherapy is preferred.
Linking CEO Celebrity to the Ethical Behavior of Family Firms in a Digital Age: Evidence from China
Authors: Chin Tachia , Singh Sanjay Kumar , Wu Liang , Lamprinakos Grigorios 
Published: February 2025

Abstract
Given the widespread use of social media, growing interest has been paid to the nexus of corporate ethics and the celebrity status of chief executive officers (CEOs). This is of even more paramount importance in family-owned firms that are very sensitive to public image and its ethical relevance. However, no empirical evidence has been found. In response, the purpose of this paper is to examine the mechanisms through which family business ethics and CEO celebrity are associated, as well as the moderating influence of a leader's personal traits on these relationships. According to secondary data from listed Chinese family firms, from 2013 to 2020, the celebrity status of CEOs was strongly connected with the ethical behavior of organizations; however, this link was mitigated by the heterogeneity of CEOs. The firm's ethical behavior and the CEO's celebrity are positively correlated when the CEO is a family member; when the CEO is not a family member, the correlation is inversely U-shaped. Furthermore, the age, dualities (including the chairman role), and tenure of CEOs had a major impact on the mechanisms of CEO fame and family business ethics. The theoretical and practical implications of the study are discussed in detail.
Is Confidence in Mathematics Pedagogy Enough? Exploring Early Childhood Teachers’ Mathematics Beliefs and Confidence
Authors: Papic Marina M. , Papic Christopher 
Published: February 2025

Abstract
A multicentre cross-sectional study of early childhood teachers (ECTs) from one large Australian not-for-profit early childhood organisation in preschool (3–5 years) classrooms, was conducted. This study was part of a quasi-experimental online Mathematics Professional Learning Program intervention aimed at developing ECTs’ mathematical pedagogical content knowledge; we report on ECTs’ (n = 325) pre-program survey scores, investigating their beliefs and confidence around mathematical pedagogy and their beliefs of preschoolers’ mathematical abilities. Scores were high, especially for confidence in pedagogical knowledge and pedagogical ability in helping children learn mathematics, and several survey constructs were significantly inter-related. However, more than half of the ECTs did not agree that most children enter preschool with some mathematics abilities, and confidence in their own mathematical abilities in areas of numeracy and spatial awareness varied. Mathematics focussed Environmental Rating Scale, Early Childhood Environment Rating Scale—Extension (ECERS-E) and Sustained Shared Thinking and Emotional Wellbeing (SSTEW) scale, item scores were evaluated for a representative subgroup of ECTs (n = 102) and overall showed minimal (3 out of 7) quality learning environments. Mathematical beliefs and confidence had a weak association with mathematics focused ECERS-E scores and no association with SSTEW scores. The results show that while beliefs and confidence were high, they did not predict the quality of the preschool learning environment. ECTs may be unaware of the specific mathematical content knowledge and pedagogical content knowledge required to effectively teach mathematics to preschool children and develop children’s complex mathematical thinking. Implications for professional learning are discussed.
Large nitrous oxide emissions from arable soils after crop harvests prior to sowing
Authors: Maier Regine , Hörtnagl Lukas , Buchmann Nina 
Published: February 2025

Abstract
Global agriculture is the largest anthropogenic source for nitrous oxide (N2O) emissions. During crop rotations, periods with arable soils without crops, thereafter called “bare soils” are often impossible to avoid after the crop is harvested, prior to sowing of the next crop. However, such periods are underrepresented in studies focussing on N2O emissions. Here, we present continuous, high-temporal-resolution N2O fluxes during bare soil periods after four major crops, using the eddy-covariance technique at two sites in Switzerland. Overall, periods with bare soil were net sources for N2O as well as for carbon dioxide (CO2) and methane (CH4). Daily average sums of N2O emissions varied between 10 ± 2 and 38 ± 5 g N2O-N ha−1 d−1 after the respective rapeseed, winter wheat, pea, and maize harvests. While CO2 emissions contributed 86–96% to the total GHG budgets, N2O fluxes accounted for 2% after pea, but for 10–12% after rapeseed, winter wheat, and maize. In contrast, CH4 fluxes were negligible (< 2%). N2O fluxes during bare soil periods increased for all cropland sites with increasing water-filled pore space, particularly at high soil temperatures. Thus, our study emphasizes the significance of avoiding bare soil periods to mitigate N2O emissions from croplands.
Examining Virtual Reality Interventions for Social Skills in Children with Autism Spectrum Disorder: A Systematic Review
Authors: Altın Yücel , Boşnak Özge , Turhan Ceyda 
Published: February 2025

Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is characterized by limitations in social communication and interaction, self-repetitive behaviors, and the presence of limited interests. The prevalence of ASD, which typically emerges in the first years of life, is increasing at an alarming rate due to multiple factors, including the broadening of diagnostic criteria, heightened public awareness, and more frequent diagnoses among women and adults. Over the years, experts have invested considerable time and effort in developing educational scenarios for children with ASD. However, they have faced challenges replicating certain scenarios—such as emergencies, crowded public transportation, or restaurant environments—because recreating these exact conditions in real-world settings is difficult or cost-prohibitive. This has consequently compelled experts to seek out supplementary intervention methods that are more suitable and accessible. Virtual reality (VR), which has the capacity to integrate the physical and virtual realms, represents one such alternative intervention method. In this study, a systematic review of studies employing VR technology in social skills interventions for individuals with ASD was conducted, and 31 studies were included. The findings indicate the potential benefits of VR applications focusing on the social skills of individuals with ASD. Additionally, this research elucidates the limitations of the studies and offers suggestions for future research.
Current state of natural and artificial radiation in the Eastern Black Sea Coast of Türkiye (Trabzon–Rize–Artvin) 38 years after Chernobyl
Authors: Uzun Duran Selcen 
Published: February 2025

Abstract
The aim of this study was to evaluate the artificial and natural radiation dose levels in the coastal areas of Trabzon–Rize–Artvin provinces 38 years after the Chernobyl nuclear accident. Radioactive 232Th, 238U, 40K and 137Cs concentrations were determined in 49 soil samples by HPGe gamma spectrometry. Average concentrations were 12 Bqkg−1 for 238U, 15 Bqkg−1 for 232Th, 162 Bqkg−1 for 40K and 37 Bqkg−1 for 137Cs. Annual effective dose equivalents and excess lifetime cancer risk values are below the world average. This study also presents the average 137Cs value measured in the same area from 1990–2004–2024.
Plasmodium yoelii as a model for malaria: insights into pathogenesis, drug resistance, and vaccine development
Authors: Otun Oluwatobi , Achilonu Ikechukwu 
Published: February 2025

Abstract
Malaria continues to pose a serious global health threat, with rising drug resistance making treatment more difficult. Consequently, Plasmodium yoelii, a rodent malaria parasite, has become an invaluable model for studying the malaria parasite’s complex biology, particularly host-parasite interactions and drug resistance mechanisms. Originating from African rodents, P. yoelii presents unique genetic diversity, mirroring critical aspects of human malaria and allowing for detailed research on the parasite’s pre-erythrocytic and erythrocytic stages. This review introduces a novel perspective by comprehensively examining P. yoelii from multiple angles, including its origin, genetic composition, and contributions to vaccine development and drug efficacy studies. It highlights the significance of P. yoelii, revealing new insights into immune evasion, pathogenesis, and disease severity, which are critical for developing future malaria interventions. Furthermore, this review addresses the challenges associated with P. yoelii as a model, such as differences in host immune responses between rodents and humans. Despite these hurdles, the research using P. yoelii offers promising directions for combating malaria. This novel synthesis of P. yoelii studies underscores its essential role in advancing malaria research, particularly in understanding drug resistance and uncovering potential therapeutic and vaccine targets.

Graphical Abstract
Enhanced utility estimation algorithm for discrete choice models in travel demand forecasting
Authors: Ghorbani Amir , Nassir Neema , Lavieri Patricia Sauri , Beeramoole Prithvi Bhat , Paz Alexander 
Published: February 2025

Abstract
Recent data-driven discrete choice models in travel demand forecasting have achieved improved predictability. However, such prediction improvements come at the cost of black-box models and lost transparency in travel demand forecasting, which makes scenario testing and transportation planning difficult (if not impossible). Furthermore, these predictability gains have often been modest compared to handcrafted parsimonious models, which benefit from enhanced behavioural interpretability and transparency. This paper introduces a novel bi-level model and estimation framework (DUET) to enhance predictability in traditional utility-based discrete choice models. The proposed model improves the specification process by identifying effective variable transformations and interactions in utility functions. Utilising a genetic algorithm, the upper level of our framework selects feasible functional forms from an extensive array, while the lower level applies iterative singular value decomposition and maximum likelihood estimation to optimise model parameters and prevent overfitting. This approach ensures superior predictability through a general utility functional form that considers extensive variable interactions. Case studies on both synthetic data and the Swissmetro dataset highlight the framework’s effectiveness in improving model performance and uncovering critical behavioural patterns and latent trends. Notably, incorporating interactions among variables in Swissmetro data, our model demonstrates a 6.5% improvement in the Brier score (probabilistic prediction accuracy) compared to the state-of-the-art deep neural network-based discrete choice model.Lastly, our results on transport mode choice data align with existing literature, indicating that younger individuals are less sensitive to travel costs. This confirms the need for targeted pricing policies to encourage public transit use among different age groups.