bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Dinuclear MnIII–CuII Single‐Molecule Magnet
Authors: Oshio Hiroki , Nihei Masayuki , Yoshida Ayano , Nojiri Hiroyuki , Nakano Motohiro , Yamaguchi Akira , Karaki Yoshitomo , Ishimoto Hidehiko 
Published: December 2004

AbstractThe reaction of 1/3 equivalent of CuCl2⋅2 H2O with MnCl2⋅4 H2O and 5‐bromo‐2‐salicylideneamino‐1‐propanol (H25‐Br‐sap) in methanol gave dark brown crystals of [MnIIICuIICl(5‐Br‐sap)2(MeOH)] (1). Complex 1 has an alkoxo‐bridged dinuclear core of MnIII and CuII ions, which have elongated octahedral and square‐planar coordination geometries, respectively. In dc magnetic susceptibility measurements, χmT values increased as the temperature was lowered, followed by a sudden decrease below 20 K. This behavior is indicative of the occurrence of intramolecular ferromagnetic interactions, and fitting gave an S=5/2 spin ground state with an exchange coupling constant JMnCu of +78 cm−1. Magnetization data collected as a function of temperature and applied magnetic field were analyzed by using a spin Hamiltonian with isotropic Zeeman and axial zero‐field splitting (ZFS) terms, and a negative D5/2 value (−1.86 cm−1) was obtained. A high‐field EPR (HFEPR) spectrum (342.0 GHz) at 4.2 K was composed of four peaks, and two additional peaks at higher magnetic field appeared as the temperature was increased. The temperature dependences in the HFEPR spectra are indicative of a negative D5/2 value, and fitting of the data gave D5/2=−1.81 cm−1. In the ac magnetic susceptibility measurements, frequency dependent in‐phase (χm′) and out‐of‐phase (χm′′) signals with peak maxima at 0.7–1.5 K were observed and small peaks below 0.7 K appeared. The ac susceptibility data supports that 1 is a single‐molecule magnet (SMM). Arrhenius plots for the χm′′ peaks from 0.7–1.5 K gave the re‐orientation energy barrier (ΔE) of 10.5 K with a pre‐exponential factor of 8.2×10−8 s.
Synthesis and Structure of [C3N2H5] [Cu(H2PO4)2Cl]×H2O with a Chain Structure: The First Example of an Organically Templated Copper(II) Phosphate.
Authors: Neeraj S. , Loiseau T. , Rao C. N. R. , Cheetham Anthony K. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of α‐Amino 1,3‐Dithioketals from Sulfinimines (N‐Sulfinyl Imines). Synthesis of (2S,3R)‐(‐)‐3‐Hydroxy‐3‐methylproline.
Authors: Davis Franklin A. , Ramachandar Tokala , Liu Hu 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chiral Norbornadienes as Efficient Ligands for the Rhodium‐Catalyzed Asymmetric 1,4‐Addition of Arylboronic Acids to Fumaric and Maleic Compounds.
Authors: Shintani Ryo , Ueyama Kazuhito , Yamada Ichiro , Hayashi Tamio 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Peroxide Compounds by the BF3‐Catalyzed Reaction of Acetals and Enol Ethers with H2O2.
Authors: Terent'ev A. O. , Kutkin A. V. , Platonov M. M. , Vorontsov I. I. , Antipin M. Yu. , Ogibin Yu. N. , Nikishin G. I. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Tributyl(3,3,3‐trifluoro‐1‐propynyl)stannane as an Efficient Reagent for the Preparation of Various Trifluoromethylated Heterocyclic Compounds.
Authors: Hanamoto Takeshi , Hakoshima Yuhko , Egashira Mikio 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Pot Assembly of Tricyclo[6.2.1.01,6]undecan‐4‐one and Related Polycyclic Compounds by Tandem Electroreductive Cyclization.
Authors: Toyota Masahiro , Ilangova Andivelu , Kashiwagi Yoshitomo , Ihara Masataka 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Efficiency of a New Tridentate Ferrocenyl Phosphine Auxiliary: Sonogashira Cross‐Coupling Reactions of Alkynes with Aryl Bromides and Chlorides at Low Catalyst Loadings of 10‐1 to 10‐4 mol %.
Authors: Hierso Jean‐Cyrille , Fihri Aziz , Amardeil Regine , Meunier Philippe , Doucet Henri , Santelli Maurice , Ivanov Vladimir V. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Simple Approach to the Synthesis of Dialkyl 5‐tert‐Butylamino‐[2,2′]bifuranyl‐3,4‐dicarboxylates.
Authors: Yavari Issa , Nasiri Farough , Moradi Loghman , Djahaniani Hoorieh 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regiospecificity of Nucleophilic Substitution in 4,6‐Dinitro‐1‐phenyl‐1H‐indazole.
Authors: Starosotnikov A. M. , Lobach A. V. , Kachala V. V. , Shevelev S. A. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimicrobial Activities of Some New 1‐(5‐Phenylamino‐[1,3,4]thiadiazol‐2‐yl)methyl‐5‐oxo‐[1,2,4]triazole and 1‐(4‐Phenyl‐5‐thioxo‐[1,2,4]triazol‐3‐yl)methyl‐5‐oxo‐[1,2,4]triazole Derivatives.
Authors: Demirbas Neslihan , Karaoglu Senguel Alpay , Demirbas Ahmet , Sancak Kemal 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel Hydropyrazolopyridine Derivatives in Solvent‐Free Conditions via Benzotriazole Methodology.
Authors: Abonia Rodrigo , Rengifo Emerson , Quiroga Jairo , Insuasty Braulio , Cobo Justo , Nogueras Manuel 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Green Chemical Synthesis of Fluorinated 1,3,5‐Triaryl‐s‐triazines in Aqueous Medium under Microwaves as Potential Antifungal Agents.
Authors: Dandia Anshu , Arya Kapil , Sati Meha , Sarawgi Pritima 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective Synthesis of 4‐ and 5‐Oxazole‐phosphine Oxides and ‐phosphonates from 2H‐Azirines and Acyl Chlorides.
Authors: Palacios Francisco , Ochoa de Retana Ana M. , Gil Jose I. , Alonso Jose M. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Derivatives of Prenylacetic Acids by Reactions of Alkyl Malonate, Cyanoacetate, and Acetoacetate with Alkylating Reagents in Ionic Liquids.
Authors: Kryshtal G. V. , Zhdankina G. M. , Zlotin S. G. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ultrasound Promoted Synthesis of (.+‐.)‐8‐Hydroxy‐5‐isopropyl‐8‐methyl‐6(E)‐nonen‐2‐one ((.+‐.)‐Solanone Hydrate) and 3,7‐Dimethyl‐2(E),7‐octadienylpropionate.
Authors: Singh Vasundhara , Chaudhary Sangeeta , Sapehiyia Varinder , Kaur Irvinder , Kad Goverdhan Lal , Singh Jasvinder 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity.
Authors: Fujimoto Haruhiro , Nakamura Etsuko , Okuyama Emi , Ishibashi Masami 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Aminoalkylation of 10‐Hydroxycamptothecin Using Methylene Chloride under Solid—Liquid Phase Transfer Catalysis: A New Approach for the Preparation of Topotecan.
Authors: Puri S. C. , Handa G. , Dhar K. L. , Suri O. P. , Qazi G. N. 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel 26‐Substituted Milbemycin A4 Derivatives and Their Acaricidal Activities.
Authors: Tsukiyama Takahiro , Kajino Hisaki , Tsukamoto Yoshihisa , Nakagawa Harumi , Yanai Toshiaki , Sato Kazuo , Yokoi Shinji , Ichinose Reiji , Tanaka Keiji 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cephalosporins with the Dichlorophenyl Group at C‐7 Position and Pyrimidines at C‐3 Position Exhibiting Potent Activity Against Gram‐Positive Strains.
Authors: Kim Geun Tae , Ryu Eun‐Jung , Jang Yong‐Jin , Lee Chang‐Seok , Youn Hasik , Cho Yang Rae , Joo Hyung Yeul 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cephalosporins with the (E)‐Thiovinyl Linker with Pyrimidine at C‐3 Position Exhibiting Potent Activities Against Gram‐Positive Strains.
Authors: Kim Geun Tae , Jang Yong‐Jin , Ryu Eun‐Jung , Koo Ki Dong , Lee Chang‐Seok , Youn Hasik , Cho Yang Rae , Joo Hyung Yeul 
Published: December 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crystallographic texture for tube and plate of the superelastic/shape‐memory alloy Nitinol used for endovascular stents
Authors: Robertson S. W. , Imbeni V. , Wenk H.‐R. , Ritchie R. O. 
Published: December 2004

AbstractThe superelastic/shape‐memory material, Nitinol, an approximately equiatomic alloy of Ni and Ti, is rapidly becoming one of the most important metallic implant materials in the biomedical industry, in particular for the manufacture of endovascular stents. As such stents are invariably laser‐machined from Nitinol tubes or sheets rolled into tubes, it is important to fully understand the physical phenomena that may affect the mechanical behavior of this material. With tubing and plate, one major issue is crystallographic texture, which can play a key role in influencing the mechanical properties of Nitinol. In this article, we present a study on how geometry and heat treatment can affect the texture of Nitinol, with specific quantification of the texture of Nitinol tube used for the production of endovascular stents. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 72A: 190–199, 2005
Culturing primary brain astrocytes under a fully controlled environment in a novel bioreactor
Authors: Santos Sónia Sá , Fonseca Luís L. , Monteiro Miguel A.R. , Carrondo Manuel J.T. , Alves Paula M. 
Published: December 2004

AbstractWe report the first approach for growth and maintenance of primary astrocytes on a fully controlled environment. For this purpose, cells were immobilized in Cytodex microcarriers and grown in a stirred tank bioreactor. The distribution of astrocytes at the microcarrier surface was visualized using confocal microscopy and glial fibrillary acidic protein (GFAP) labeling, a specific glial probe. Crucial bioreaction parameters such as agitation rate, microcarrier type, and concentration, as well as cell inoculum concentration were assessed. Cytodex 3 proved the best microcarrier for astrocyte growth, with the highest cell densities obtained for 6 g/l of Cytodex 3 using an inoculum of approx. 0.15 × 106cells/ml in vessels operated at 60 rpm, using a refeed operational mode consisting of complete medium replacement every 5 days. Using such optimized conditions, cells were maintained in steady‐state for approximately 24 days, allowing online monitoring and control of environmental variables such as temperature, pH, and O2. To test further the advantages of this fully controlled system, astrocytes were also subjected to hypoxic stress for 5 hr; the cell number was not affected by hypoxia but the glycolytic flux was enhanced during the stress imposed. The culture system described is a novel tool to study brain cell metabolism, allowing sampling over time and the monitoring of cellular behavior through stressful conditions and during recovery. © 2004 Wiley‐Liss, Inc.
Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet‐derived growth factor‐BB
Authors: Dang Ian , DeVries George H. 
Published: December 2004

AbstractNeurofibromatosis type 1 (NF1) is a genetic disease caused by the loss of neurofibromin, which can lead to formation of highly invasive malignant peripheral nerve sheath tumors (MPNST). We characterized platelet‐derived growth factor‐β (PDGF‐β) receptor expression levels and signal transduction pathways in NF1 MPNST cell lines and compared them with the expression of PDGF‐β receptors in normal human Schwann cells (nhSC). As examined by Western blotting, PDGF‐β receptor expression levels were similar in nhSC and NF1 MPNST cell lines. MAPK and Akt also were phosphorylated in both cell types to a similar degree in response to PDGF B chains (PDGF‐BB). However, increased intracellular calcium (Ca2+) levels in response to PDGF‐BB were observed only in the NF1 MPNST cell lines; nhSC did not show any increase in intracellular calcium when stimulated with PDGF‐BB. The calcium response in NF1 MPNST cell lines was blocked with thapsigargin, suggesting that the PDGF‐BB‐stimulated increases in intracellular calcium originated in the internal compartment of the cell rather than reflecting influx of calcium from the extracellular compartment. Calmodulin kinase II (CAMKII) is phosphorylated in response to PDGF‐BB in the NF1 MPNST cell lines, whereas no phosphorylation of CAMKII was observed in nhSCs. The decreased growth of NF1 MPNST cell lines after treatment with a CAMKII inhibitor is consistent with the view that aberrant activation of the calcium‐signaling pathway by PDGF‐BB contributes to the formation of MPNST in NF1 patients. © 2004 Wiley‐Liss, Inc.
Delay discounting determines delivery fees in an e‐commerce simulation: A behavioral economic perspective
Authors: Hantula Donald A. , Bryant Kimberly 
Published: December 2004

AbstractParticipants ordered music CDs and bargained for delivery time and fees in a simulated on‐line store. After ordering a CD, participants engaged in a delivery‐fee bargaining task that was embedded in a psychophysical up–down staircase titration procedure in which options of next‐day delivery for a fee and delayed free delivery were made more or less attractive based on previous choices. A hyperbolic function derived from the matching law fit the data. These results are consistent with a behavioral‐economic account of intertemporal choice in which delivery fees are seen as a swap of money for time. © 2005 Wiley Periodicals, Inc.
In‐line optical detection in the transient state of extrusion polymer blending and reactive processing
Authors: Mélo Tomás Jeferson A. , Canevarolo Sebastião V. 
Published: December 2004

AbstractUsing an opticaldetector we followed the transient state of blends and composites, including a reactive blending during extrusion. The detection system is composed of a slit‐die with transparent windows fixed at the extruder exit, an optical arrangement with a W incandescent light microbulb with fixed luminescence, and a CdS photocell. As the tracer passes though the light path, it absorbs and backscatters part of the light, reducing the total transmitted light intensity. This is followed by changes in the voltage induced by the photocell to an electric circuit. We calibrated the response of the photocell at room temperature using a set of various films with a second phase dispersed, and obtained a logarithmic relationship. The tracers were particulate (phthalocyanine, TiO2) and polymeric (PS, PA6) phases that absorb and scatter light, producing a residence time distribution (RTD) curvelike trace. Measurements were taken from a twin‐screw extruder Werner‐Pfleiderer ZSK 30 equipped with K‐Tron gravimetric feeders operating at various screw configurations and speeds, and feeding rates. The transient state of PP/PA6 blends can be easily detected optically and recorded using one of the components (either PP or PA6) added as a pulse in a steady‐state flow of the other component. With the simultaneous addition of a compatibilizer (polypropylene grafted with acrylic acid (PP‐g‐AA)) with the PA6, the intensity of the detector signal is substantially increased as a result of the PA6/PP‐g‐AA reaction. Quantitative off‐line infrared spectroscopy of the total amide group corroborated the in‐line measurements. These observations suggest that an in‐line optical detector may be a fast and simple way to study the flow behavior of blends and composites, including reactive processing. POLYM. ENG. SCI. 45:11–19, 2005. © 2004 Society of Plastics Engineers.
A novel strategy for quantitative proteomics using isotope‐coded protein labels
Authors: Schmidt Alexander , Kellermann Josef , Lottspeich Friedrich 
Published: December 2004

AbstractStable isotope labelling in combination with mass spectrometry has emerged as a powerful tool to identify and relatively quantify thousands of proteins within complex protein mixtures. Here we describe a novel method, termed isotope‐coded protein label (ICPL), which is capable of high‐throughput quantitative proteome profiling on a global scale. Since ICPL is based on stable isotope tagging at the frequent free amino groups of isolated intact proteins, it is applicable to any protein sample, including extracts from tissues or body fluids, and compatible to all separation methods currently employed in proteome studies. The method showed highly accurate and reproducible quantification of proteins and yielded high sequence coverage, indispensable for the detection of post‐translational modifications and protein isoforms. The efficiency (e.g. accuracy, dynamic range, sensitivity, speed) of the approach is demonstrated by comparative analysis of two differentially spiked proteomes.
A subcellular prefractionation protocol for minute amounts of mammalian cell cultures and tissue
Authors: Guillemin Isabelle , Becker Michael , Ociepka Kornelia , Friauf Eckhard , Nothwang Hans Gerd 
Published: December 2004

AbstractSubcellular localization represents an essential, albeit often neglected, aspect of proteome analysis. Generally, the subcellular location of proteins determines the function of cells and tissues. Here we present a robust and versatile prefractionation protocol for mammalian cells and tissues which is appropriate for minute sample amounts. The protocol yields three fractions: a nuclear, a cytoplasmic, and a combined membrane and organelle fraction. The subcellular specificity and the composition of the fractions were demonstrated by immunoblot analysis of five marker proteins and analysis of 43 proteins by two‐dimensional gel electrophoresis and mass spectrometry. To cover all protein species, both conventional two‐dimensional and benzyldimethyl‐n‐hexadecyl ammonium chloride‐sodium dodecyl sulfate (16‐BAC‐SDS) gel electrophoresis were performed. Integral membrane proteins and strongly basic nuclear histones were detected only in the 16‐BAC‐SDS gel electrophoresis system, confirming its usefulness for proteome analysis. All but one protein complied to the respective subcellular composition of the analyzed fractions. Taken together, the data make our subcellular prefractionation protocol an attractive alternative to other prefractionation methods which are based on less physiological protein properties.
The Holm Oak leaf proteome: Analytical and biological variability in the protein expression level assessed by 2‐DE and protein identification tandem mass spectrometry de novo sequencing and sequence similarity searching
Authors: Jorge Inmaculada , Navarro Rafael M. , Lenz Christof , Ariza David , Porras Carlos , Jorrín Jesús 
Published: December 2004

AbstractAs a first approach in establishing the holm oak leaf proteome, we have optimised a protocol for this plant and tissue which includes the following steps: trichloroacetic acid‐acetone extraction, two‐dimensional gel electrophoresis (2‐DE) on pH 5 to 8 linear gradient immobilised pH gradient strips as the first dimension, and sodium dodecyl sulfate‐polyacrylamide gel electrophoresis on 13% polyacrylamide gels as the second one. Proteins were detected by Coomassie staining. Gel images were recorded and digitalized, and the protein spots quantified by using a linear regression equation of protein quantity on spot volume obtained against standard proteins. Analytical variance was calculated for one‐hundred protein spots from three replicate 2‐DE gels of the same protein extract. Biological variance was determined for the same protein spots from independent tissue extracts corresponding to leaves from different trees, or the same tree at different orientations or sampling times during a day. Values of 26% for the analytical variance and 58.6% for the biological variance among independent trees were obtained. These values provide a quantified and statistical basis for the evaluation of protein expression changes in comparative proteomic investigations with this species. A representative set of the major proteins, covering the isoelectric point range of 5 to 8 and the relative molecular massr range of 14 to 78 kDa, were subjected to liquid chromatography‐tandem mass spectrometry analysis. Due to the absence of Quercus DNA or protein sequence databases, a method based on the procedure reported by Liska and Shevchenko [1] including de novo sequencing and BLAST similarity searching against other plant species databases was used for protein identification. Out of 43 analysed spots, 35 were positively identified. The identified proteins mainly corresponded to enzymes involved in photosynthesis and energetic metabolism, with a significant number corresponding to RubisCO.
Partial hepatectomy induced liver proteome changes in mice
Authors: Strey Christoph W. , Winters Mike S. , Markiewski Maciej M. , Lambris John D. 
Published: December 2004

AbstractAcceleration of liver regeneration could be of great clinical benefit in various liver‐associated diseases. However, at present little is known about therapeutic interventions to enhance this regenerative process. Our limited understanding and the complexity of the mechanisms involved have prevented the identification of new targets for treatment. Here we propose a broad‐range proteomic approach to this problem that makes possible the simultaneous study of different signaling and metabolic pathways on the liver proteome. Changes in protein expression in mouse livers (n = 5 per group) at 6 h and 12 h after partial hepatectomy and sham operation, as compared to untreated controls, were analyzed using two‐dimensional gel electrophoresis, mass spectrometry (MS), and mass fingerprinting. Twelve proteins, identified by MS, were up‐regulated by at least 2‐fold after partial hepatectomy. These included adipose differentiation‐related protein, gamma‐actin, enoyl coenzyme A hydratase 1, serum amyloid A and eukaryotic translation initiation factor 3. These results indicate that liver regeneration following partial hepatectomy affects various signaling and metabolic pathways.
Preparation and physical properties of novel nonionic surfactants and their grafting copolymers with linear low density polyethylene (LLDPE)
Authors: Xin Zhirong , Ding Yongtao , Yin Jinghua , Ke Zhuo , Xu Xiaodong , Gao Ying , Costa Giovanna 
Published: December 2004

AbstractThree nonionic surfactants, S1, S2, and S3 and their acrylates, AS1, AS2, and AS3, were synthesized with poly(ethylene oxide) and diols such as glycol, 1,6‐hexanediol, and 1,10‐decanediol as the main starting materials. Their chemical structures were characterized by means of Fourier transform infrared (FTIR) spectroscopy and 1H NMR. The surface activity and surface tension (γ) of S1, S2, and S3 were evaluated by a drop weight method. The surface tension was found to decrease with the length of the lipophilic spacer in the molecular chains (γS1 < γS2 < γS3). AS1, AS2, and AS3 were adopted as functionalizing monomers and grafted onto linear low density polyethylene (LLDPE) with a melt reactive extrusion procedure. The graft degrees of LLDPE were determined by FTIR. Three grafted LLDPE samples with grafting degrees of 1.16% (AS1), 0.82% (AS2), and 0.71% (AS3) were prepared. Thermal and rheological properties of grafted LLDPE samples were studied with differential scanning calorimetry and a rotational rheometer. Crystallization rates of grafted LLDPE were faster than that of plain LLDPE at a given crystallization temperature because graft chains could act as nucleating agents. The isothermal crystallization behavior of grafted LLDPE was in accordance with the Avrami model only in the first stage, and deviated from the model with an increase in the crystallization time. Shear thinning at high shear rates and shear thickening at low shear rates were observed for the grafted LLDPE. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 314–322, 2005