bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mathematical representation of electrophoretic mobility in mixed aqueous‐methanolic buffers in capillary zone electrophoresis
Authors: Jouybana A. , Chan H. K. , Clark B. J. , Kenndler E. 
Published: August 2002

AbstractIn a drug development program improved speed of the development phase is constantly being explored. But much effort and time is usually expended in finding suitable methods for pharmaceutical and biomedical analyses. In contrast, a mathematical model has been presented here to correlate/predict electrophoretic mobility of acidic and basic analytes in capillary electrophoresis at different concentrations of organic modifier. This model could help analysts to find the optimum concentration of organic modifier for a successful analysis. The accuracy and predictability of the proposed model have been shown using generated mobility data (five basic drugs in water‐methanol mixed running buffer) and previously published data sets collected from a recent publication. Using this model the average percentage errors for correlative and predictive equations were 0.64 and 1.35%, respectively. The accuracy of the model was also examined against those of previously published models where the results are comparable. © 2001 John Wiley & Sons, Inc. J Micro Sep 13: 346–350, 2001
Phenotypic characterisation of autosomal recessive PARK6‐linked parkinsonism in three unrelated Italian families
Authors: Bentivoglio Anna R. , Cortelli Pietro , Valente Enza M. , Ialongo Tàmara , Ferraris Alessandro , Elia Antonio , Montagna Pasquale , Albanese Alberto 
Published: August 2002

AbstractThe clinical features of nine patients (three women and six men) affected by PARK6‐linked parkinsonism, belonging to three unrelated Italian families, are reported. The occurrence of affected men and women within one generation suggested an autosomal recessive mode of inheritance in all three families. Mean age at disease onset was 36 ± 4.6 years; all cases except one presented with asymmetrical signs, consisting of tremor and akinesia of one upper limb or unilateral short step gait. Affected individuals had a mean age of 57 ± 8.5 years, and average disease duration was 21 ± 7.8 years. Parkinsonian features included benign course, early onset of drug‐induced dyskinesias, and a good and persistent response to levodopa. There were no other associated features (i.e., pyramidal or cerebellar signs, dysautonomia, or diurnal fluctuations unrelated to drug treatment). Cognition was unaffected. The clinical picture was remarkably similar in all patients; no relevant family‐related differences were found. PARK6 disease is a new form of early‐onset parkinsonism without other atypical clinical features. © 2001 Movement Disorder Society.
Bilaterally coherent tremor resembling enhanced physiological tremor: Report of three cases
Authors: O'Sullivan John D. , Rothwell John , Lees Andrew J. , Brown Peter 
Published: August 2002

AbstractThe contribution of the central nervous system to tremor pathogenesis is unclear. Poor side‐to‐side coherence in physiological, essential, and parkinsonian tremors suggests distinct bilateral generators. By contrast, significant bilateral coherence demonstrated in orthostatic tremor and in enhanced physiological tremor (EPT) in patients with persistent mirror movements favours single or closely linked bilateral oscillators. We describe three patients (aged 21–37 years) who developed unusual bilateral postural and kinetic tremors at 6–13 Hz resembling EPT. The tremor involved all limbs, and in two cases the face or jaw, in the absence of other significant neurological features. Significant side‐to‐side coherence was demonstrated in each case using cross‐correlation of electromyographic recordings from homologous muscle pairs. We postulate that these unusual tremors originate from a single brainstem source or from bilateral oscillators closely linked at or below this level. © 2002 Movement Disorder Society
Erythropoietin deficiency and anaemia in multiple system atrophy
Authors: Winkler Andrea S. , Marsden Joanne , Parton Matthew , Watkins Peter J. , Chaudhuri K. Ray 
Published: August 2002

AbstractSerum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia, are EPO‐deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron‐deficiency anaemia, and 18 healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 ± 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas none of the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron‐deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension, which may be associated with EPO deficiency. This may have therapeutic implications. © 2001 Movement Disorder Society.
Playing harp, another unusual task‐specific dystonia
Authors: Gatto Emilia Mabel , Pardal Manuel María Fernandez , Reisin Ricardo Claudio , Pardal Ana María 
Published: August 2002

AbstractHerein we report a task‐specific dystonia in a 48‐year‐old woman, with an unusual association between a familial harp‐playing dystonia and essential tremor. © 2001 Movement Disorder Society.
Comparison of clinical vs. electrophysiological methods of diagnosing of essential tremor
Authors: Louis Elan D. , Pullman Seth L. 
Published: August 2002

AbstractEssential tremor (ET) may be differentiated from normal or enhanced physiological tremor based on a clinical examination or electrophysiological tests such as quantitative computerized tremor analysis. There have been few head to head comparisons of the two methods. Our objective was to estimate diagnostic agreement between these two methods. Cases and controls underwent a clinical evaluation (interview and videotaped examination) and an electrophysiological evaluation (quantitative computerized tremor analysis using accelerometry and electromyography) on the same day, and diagnoses were independently assigned using clinical vs. electrophysiological criteria. Agreement between diagnoses was assessed with a concordance rate and kappa statistic (κ).Thirty‐two (59.3%) of 54 subjects were diagnosed clinically as ET (possible, probable, or definite), compared with 35 (64.8%) of 54 based on tremor analysis. The concordance rate between the two methods of diagnosis was 94.4% (51 of 54). κ was 0.88, indicating a level of agreement between diagnoses that was in the “near perfect” range. All of the subjects who received electrophysiological diagnoses of definite ET also received clinical diagnoses of ET. Conversely, all of the subjects who received clinical diagnoses of definite ET also received electrophysiological diagnoses of ET. The agreement between the clinical and electrophysiological diagnosis of ET was substantial, suggesting that study protocols that were to utilize either technique would arrive at similar diagnostic conclusions. In addition, physiological testing can quantify potentially valuable subclinical measurements as well as detect possible additional cases of ET not diagnosed as such during clinical assessments. © 2001 Movement Disorder Society.
Methods for digital video recording, storage, and communication of movement disorders
Authors: Jog Mandar S. , Grantier Linda 
Published: August 2002

AbstractVideo technology has now reached a level of sophistication that allows easy digitization. Digital video can be easily edited, reproduced, incorporated into databases, and posted on intra‐ and Internet sites for clinical use and demonstration purposes. Numerous methods exist for the production of digital video. This article synthesizes and simplifies the available methodologies in order to easily choose the technology that is the most appropriate for the movement disorder specialist's end use. Depending on available resources, issues such as cost, ease, and time to conversion are discussed. In addition, our experience with the use of one of the methodologies is briefly presented. © 2001 Movement Disorder Society.
Sequence variation in GAA repeat expansions may cause differential penotype display in Friedreich's ataxia
Authors: McDaniel D. Olga , Keats Bronya , Vedanarayanan V.V. , Subramony S.H. 
Published: August 2002

AbstractFriedreich's ataxia, the most common autosomal recessive inherited ataxia, is characterized by progressive gait and limb ataxia. Friedreich's ataxia is known for its occurrence within the first or second decade of life and is associated with hypertrophic cardiomyopathy, and in some cases with diabetes. Genetically, it is identified by the expression of an unstable trinucleotide GAA repeat expansion located in the first intron of the X25 gene on chromosome 9. Two brothers with very late adult‐onset ataxia, and their unaffected sister, were examined for the clinical presentation of FA and for the presence of the mutated FA gene. The relationship of the expanded gene sequence to the severity of disease and age of onset were evaluated. Clinical examination revealed that the two brothers had mild ataxia and proprioceptive loss, with age of onset between 60 and 70 years of age. DNA from peripheral blood nucleated cells demonstrated a small homozygous expansion, with approximately 120–130 GAA repeats in the X25 gene in both patients. The expanded repeats were interrupted either with GAAGAG, GAAGGA, or GAAGAAAA sequences. The unaffected sister carried a normal FA genotype with 8‐uninterrupted GAA repeat, observed by sequence analysis. In addition, the levels of FA gene transcript in both brothers were relatively lower than that in the unaffected sister. No detectable cardiomyopathy or diabetes was observed. Phenotypic diversity of FA is increasingly expanding. The age of onset and the structure of GAA repeat expansion plays an important role in determining the clinical features and the differential diagnosis of FA. The confirmation of the FA gene mutation in the atypical case, broadens the clinical spectrum of FA, and supports the idea that patients with even a mild form of ataxia of late adult onset should be considered for molecular testing. © 2001 Movement Disorder Society.
Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6‐OHDA lesion in the rat brain
Authors: Hassani Oum‐Kaltoum , Mouroux Mireille , Bohme Georg Andrees , Stutzmann Jean‐Marie , Féger Jean 
Published: August 2002

AbstractAn abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmission, affects neuronal activity in this brain region. Intravenous administration of riluzole reduced the discharge rate of subthalamic neurons in rats with 6‐OHDA‐induced lesions of the midbrain. By contrast, no effect was observed in nonlesioned control animals. This property may contribute to the neuroprotective effects of riluzole in animal models of PD through the modulation of the glutamatergic inputs these neurons feedback to nigral dopaminergic neurons. © 2001 Movement Disorder Society.
Thalamic deep brain stimulation: Effects on the nontarget limbs
Authors: Ondo William , Dat Vuong Kevin , Almaguer Michael , Jankovic Joseph , Simpson Richard K. 
Published: August 2002

AbstractUnilateral thalamic ventral intermediate (VIM) deep brain stimulation (DBS) is now accepted as an effective treatment for essential tremor (ET) and tremor related to Parkinson's disease (PD). The effects of unilateral placement on the side ipsilateral to the surgical site have not been carefully evaluated. To systematically assess the effects ipsilateral to the surgical side and to determine the effects of device inactivation on the baseline tremor, we evaluated tremor in 73 patients approximately 3 months after their unilateral thalamic placement. Assessment included blinded and unblinded ratings using the Unified Parkinson's Disease Rating Scale for PD patients and a modified Tremor Rating Scale in ET patients. All measures of tremor contralateral to the implantation site improved significantly and robustly in both PD and ET. Implantation did not worsen tremor by any measure on the ipsilateral side. There was mild ipsilateral improvement as measured by lower observed tremor scores in ET (6.0 ± 1.8 to 5.0 ± 1.9, P < 0.005), but not PD. There was no rebound augmentation of tremor in either hand after the devices were deactivated in either group. We conclude that VIM DBS may mildly improve ipsilateral ET, and that concerns about meaningful ipsilateral tremor augmentation after device deactivation are not warranted. © 2001 Movement Disorder Society.
Effects of liposome‐mediated gene transfer of VEGF in ischemic rat gracilis muscle
Authors: Neumeister Michael W. , Song Yao‐Hua , Mowlavi Arian , Suchy Hans , Mathur Aruna 
Published: August 2002

AbstractThe purpose of the current study was to determine the effects of vascular endothelial growth factor (VEGF) on muscle flap survival and vascularity in a rat gracilis ischemia‐reperfusion model. A total of 12 adult male Wistar rats were divided into two groups (n = 6). The experimental group received the plasmid encoding VEGF165 cDNA plus lipofectamine (cationic liposome) injected directly to the gracilis muscle following 4 h of ischemia. The control group received lipofectamine only. The viability and vascularity of the flaps were evaluated after 7 days of reperfusion. The data demonstrated that the VEGF plasmid‐ and lipofectamine‐treated muscle flaps had significantly greater total survival and capillary count 7 days after reperfusion compared with the flaps treated only with lipofectamine. These results indicate that VEGF exerts a protective effect on ischemic skeletal muscle flaps. © 2001 Wiley‐Liss, Inc. MICROSURGERY 21:58–62 2001
Unique continuation for systems with Lamé principal part
Authors: Weck Norbert 
Published: August 2002

AbstractWe generalize a result concerning unique continuation for the system of linearized isotropic elasticity by admitting first‐order perturbations. The proof is based on elementary weighted L2‐inequalities. Furthermore, we extend our result to a generalization of the Lamé system in the context of alternating differential forms. Copyright © 2001 John Wiley & Sons, Ltd.
On optimal control problems connected with eigenvalue variational inequalities
Authors: Bock Igor 
Published: August 2002

AbstractThe eigenvalue optimization problem for a variational inequality over the convex cone is to be dealt with. The control variable appears in the operator of the unilateral problem. The existence theorem for the maximum first eigenvalue optimization problem is stated and verified. The necessary optimality condition is derived. The applications to the optimal design of unilaterally supported beams and plates are presented. The variable thickness of a construction plays the role of a design variable. The convergence of the finite elements approximation is proved. Copyright © 2001 John Wiley & Sons, Ltd.
Numerical modeling of omnidirectional slotted‐waveguide antennas
Authors: Wang H. Y. , Zhang S. Q. , Sangster A. J. 
Published: August 2002

AbstractSlotted‐waveguide antennas with omni‐directional radiation patterns are analyzed using the method of moments and a full‐wall electromagnetic simulator based on the finite‐difference time‐domain (FDTD) method. The resonant and radiation properties of the antennas have been examined. The simulated results are shown to be in good agreement with those obtained from measurements. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 31: 374–377, 2001.
Theoretical investigations on the propagation characteristics of transmission lines on substrates with very high dielectric constant
Authors: Seixas D. L. A. , Conrado L. F. M. , Carvalho M. C. R. 
Published: August 2002

AbstractThe propagation characteristics of enclosed microstrip‐slot and coplanar waveguide‐slot lines printed on substrates with a very high dielectric constant (εr=40, εr=80, and εr=100, respectively) are investigated for a wide range of geometric parameters. The analysis of the lines was performed using the finite‐element method. The numerical results show the dependence of the transmission‐line parameters with transversal dimensions and frequency. Also, it was verified that the substrate thickness and enclosure width are the relevant parameters which limit single‐mode operation. © 2002 John Wiley & Sons, Inc. Microwave Opt Technol Lett 32: 275–278, 2002.
A novel miniaturized microstrip bandpass filter using a meander‐line resonator
Authors: Qing X. M. , Chia Y. W. M. , Sun J. 
Published: August 2002

AbstractWe report a novel miniaturized microstrip bandpass filter with a meander‐line resonator which exhibits a much smaller size. A very compact prototype, having a size of about λg0/8×λg0/8 at a center frequency of 2.445 GHz, was designed and fabricated for a 2.4 GHz bluetooth application. The measurement results of the proposed filter are in good agreement with the simulation results. © 2002 John Wiley & Sons, Inc. Microwave Opt Technol Lett 32: 319–321, 2002.
Surface mount filter with a triple‐mode ceramic cavity
Authors: Tikhov Yuri , Kim Jeong Phill 
Published: August 2002

AbstractWe consider a novel surface mount ceramic filter for wireless communication systems. The high permittivity ceramic filling of the basic triple‐mode waveguide cavity makes proposed bandpass filters physically small. Integrated microstrip to ceramic waveguide transitions provide effective connection of the filter into a planar circuit. The theory is based on the singular integral equation method in conjunction with generalized scattering matrix technique. The principal feature of the simulation algorithm consists of utilization of weighted Gegenbauer polynomials as the basis functions for the Galerkin's procedure. A design example is shown for L‐band filter. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 33: 373–377, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10326
Constrained optimization for color pattern recognition with a nonzero order joint transform correlator
Authors: Wu Chih‐Sung , Chen Chulung , Fang Jian‐Shuen 
Published: August 2002

AbstractIn this article, we apply a novel method on color pattern recognition with the nonzero order joint transform correlator. By the special arrangement of separated RGB channels of objects and reference images at the input plane, we can predict the location of correlation outputs. Furthermore, by the use of power‐spectrum subtraction strategy, the zero‐order part can be removed. The test pattern is a frog. The desired correlation peak is found to be quite distinctive and sharp. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 33: 385–388, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10330
Beam‐switched rhombic antenna
Authors: Fusco V. F. , Li R. 
Published: August 2002

AbstractIn this paper, we show how a rhombic antenna can be operated in a degenerate fashion in order to produce a switched beam. The antenna demonstrator designed to operate at 1 GHz is shown to beam scan in elevation by about 10°, controlled only by the use of a switched 500 Ω resistor. Under these conditions, the antenna exhibits a sending end impedance variation of 1.6:1. This type of antenna could find application for use in low‐cost vehicular and asset‐tracking applications. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 84–86, 2001.
Characterization of polypropylene thin‐film microstrip lines at millimeter and submillimeter wavelengths
Authors: Nagel M. , Dekorsy T. , Brucherseifer M. , Haring Bolívar P. , Kurz H. 
Published: August 2002

AbstractWe report on the characteristics of thin‐film microstrip lines with adhesive polypropylene tape as dielectric. The attenuation and dispersion have been measured in a frequency range between 30 and 800 GHz by electro‐optical sampling. A 31‐μm‐wide PP microstrip line exhibits a low attenuation of 0.09 dB/mm and an effective permittivity εr, eff of 1.85, both at 30 GHz. Both the excellent dielectric properties as well as the high planarity appear very attractive for future waveguide structures. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 97–100, 2001.
Efficient determination of current densities induced in the human body from measured low‐frequency inhomogeneous magnetic fields
Authors: Ruoß Hans‐Oliver , Spreitzer Wolfgang , Nishizawa Shinichiro , Messy Sven , Klar Michael 
Published: August 2002

AbstractAn efficient numerical source model is proposed to calculate the induced current densities in the human body from measured low‐frequency inhomogeneous magnetic fields emitted by electronic devices (e.g., household appliances or power tools). Due to the complex geometrical structure and complicated construction of the devices, an efficient equivalent‐source formulation using magnetic elementary dipoles is determined to characterize the field source. Consequently, the validity of the proposed equivalent‐source model is confirmed, and the induced current density in the human body is calculated for several kinds of appliances. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 211–213, 2001.
Design of a large effective‐area nonzero‐dispersion fiber for DWDM systems
Authors: Survaiya S. P. , Shevgaonkar R. K. 
Published: August 2002

AbstractIn this paper, we analyze and propose an optimum index profile which can give a larger core effective area with nonzero‐dispersion characteristics. The index profile is modeled by an exponentially modulated linear chirp profile function. A linear finite‐element method (LFEM) is used for computing the transmission characteristics of an optical fiber having an arbitrary refractive‐index profile. The optimum index profile can give a core effective area of 117 μm2. The dispersion varies linearly from 2.5 to 4.5 ps/nm⋅km with a dispersion slope of 0.065 ps/nm2⋅km over the 1.53–1.56 μm wavelength range. Sensitivity analysis for the designed fiber characteristics is also studied. The bend loss is about 0.001 dB/m for a bend radius of 100 mm. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 238–244, 2001.
FDTD and TLM analysis of a PIFA using an irregularly graded space connection
Authors: Geng Hui , Hira M. , Shiozawa T. 
Published: August 2002

AbstractThis letter presents an optimization procedure for the synthesis of a planar inverted‐F antenna (PIFA). The procedure uses the combing method to exploit the advantages of the FDTD and TLM algorithms. A proposed connection interface between the FDTD and TLM with irregularly graded space was introduced in the synthesis for an optimal shape. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 259–263, 2001.
A low‐cost L‐probe patch antenna array
Authors: Wong H. , Luk K. M. 
Published: August 2002

AbstractUsing L‐probe patch antennas as elements, a simple series‐fed eight‐element array antenna is designed and tested. An impedance bandwidth of 8% (SWR≦1.5) and an average gain of 14.5 dBi have been achieved. The radiation pattern is stable across the passband with low cross polarization. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 29: 280–282, 2001.