bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of the Role of PET-CT Imaging in the Assessment of Treatment Response and its Predictive Value for Survival Outcomes in Adult patients with Newly Diagnosed Hodgkin Lymphoma: A Comparison with Conventional Imaging Techniques
Authors: Kasireddy Smaran , Nirmal Simran , Kathal Rithik , Rahul Chidurala , Shridhar Rajasundaram 
Published: January 2024

Abstract
Objective: The purpose of this research is to assess how PET-CT compares to other imaging modalities in terms of predicting the prognosis of Hodgkin's Lymphoma.
Data Sources: We screened for papers published in English between 2019 and 2023 in the MEDLINE, PubMed, Embase databases.
Study Design: To enhance clinical decision-making, we discovered studies comparing the imaging modalities
Data Collection and Extraction Methods: We designed and verified organized search queries. To improve the inclusion and exclusion criteria, abstracts were evaluated iteratively. The included studies' bibliographies were manually searched as an addition to the search. To find the clinical trial protocol and published clinical trial findings, the search comprised a forward citation search of papers nested inside a clinical trial.
Principal Findings: This study consists of four retrospective studies, one multicentric prospective study, one observational study, two prospective studies, and one randomized control trial. A total of nine studies were included with a sample size of 2143. PET - CT has been shown to have a predictive value for prognosis and for markers of metastasis compared to other imaging modalities.
Conclusions: While PET-CT has shown to be the most predominant imaging modality for diagnosing and predicting the prognosis of Hodgkins Lymphoma, further more specific trials may be required in comparison to Bone marrow biopsy and the benefits it provides over PET- CT.
Glutathione peroxidase 4 suppresses manganese-dependent oxidative stress to reduce colorectal tumorigenesis.
Authors: Xue Xiang , Liu Zhaoli , Liang Yanshan , Kwon Young-Yon , Liu Rui , Martin David , Hui Sheng 
Published: January 2024

Abstract
The role of glutathione peroxidase 4 (GPX4) in ferroptosis and various cancers is well-established; however, its specific contribution to colorectal cancer has been unclear. Surprisingly, in a genetic mouse model of colon tumors, the deletion of GPX4 specifically in colon epithelial cells increased tumor burden but decreased oxidized glutathione. Notably, this specific GPX4 deletion did not enhance susceptibility to dextran sodium sulfate (DSS)-induced colitis in mice with varied iron diets but showed vulnerability in mice with a vitamin E-deficient diet. Additionally, a high manganese diet heightened susceptibility, while a low manganese diet reduced DSS-induced colitis in colon epithelial-specific GPX4-deficient mice. Strikingly, the low manganese diet also significantly reduced colorectal cancer formation in both colon epithelial-specific GPX4-deficient and wildtype mice. Mechanistically, antioxidant proteins, especially manganese-dependent superoxide dismutase (MnSOD or SOD2), correlated with disease severity. Treatment with tempol, a superoxide dismutase mimetic radical scavenger, suppressed GPX4 deficiency-induced colorectal tumors. In conclusion, the study elucidates the critical role of GPX4 in inhibiting colorectal cancer progression by regulating oxidative stress in a manganese-dependent manner. The findings underscore the intricate interactions between GPX4, dietary factors, and their collective influence on colorectal cancer development, providing potential insights for personalized therapeutic strategies.
Insights into Enhanced Thermal Performance: Visualizing Diverse Flow Patterns in Fe3O4/Water Pulsating Heat Pipes
Authors: Goshayeshi Hamid Reza , Mousavi Seyed Borhan , Heris Saeed Zeinali , Chaer Issa 
Published: January 2024

Abstract
This paper presents the outcomes of an experimental study employing flow visualization techniques to examine diverse flow patterns within closed-loop pulsating heat pipes (PHPs) utilizing Fe3O4/water as the working medium. A high-speed digital camera was employed to capture intricate flow patterns under various experimental conditions to gain a precise understanding of the operational mechanism of the PHP. The empirical findings demonstrated that in the evaporating segment of the PHP, the prominent flow pattern involved the oscillation of liquid slugs and vapor plugs, driven by the generation and expansion of bubbles through nucleate boiling. The results indicated a shift in the primary flow pattern of a closed-loop PHP employing Fe3O4/water. This transition progressed from a bubble flow accompanied by slug flow characteristics to an annular flow pattern. Additionally, the visualization study showed distinct flow patterns in the PHP’s evaporator, adiabatic, and condenser sections when Fe3O4/water was used with varying heat inputs. Notably, the oscillatory flow behavior of Fe3O4/water, the chosen working fluid, exhibited greater activity in comparison to water. This distinctive flow behavior contributed to achieving heightened thermal performance efficiency for the Fe3O4/water system, attributed to its faster attainment of the annular flow condition.
Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention
Authors: Mohammadi Shiva , Moghadam Maryam Dalaei , Nasiriasl Maryam , Akhzari Morteza , Barazesh Mahdi 
Published: January 2024

Abstract:Resveratrol (3, 5, 4′‐trihydroxystilbene) is a polyphenolic derivative with herbal origin. It has attracted considerable attention in recent decades. Many studies have revealed the benefits of Resveratrol over several human disease models, including heart and neurological diseases, nephroprotective, immune regulation, antidiabetic, anti-obesity, age‐related diseases, antiviral, and anticancer in experimental and clinical conditions. Recently, the antioxidant and anti-inflammatory activities of Resveratrol have been observed, and it has been shown that Resveratrol reduces inflammatory biomarkers, such as tissue degradation factor, cyclooxygenase 2, nitric oxide synthase, and interleukins. All of these activities appear to be dependent on its structural properties, such as the number and position of the hydroxyl group, which regulates oxidative stress, cell death, and inflammation. Resveratrol is well tolerated and safe even at higher pharmacological doses and desirably affects cardiovascular, neurological, and diabetic diseases. Consequently, it is plausible that Resveratrol can be regarded as a beneficial nutritional additive and a complementary drug, particularly for therapeutic applications. The present review provides an overview of currently available investigations on preventive and therapeutic characteristics and the main molecular mechanisms of Resveratrol and its potent derivatives in various diseases. Thus, this review would enhance knowledge and information about Resveratrol and encourage researchers worldwide to consider it as a pharmaceutical drug to struggle with future health crises against different human disorders.
Behind the Busy Hong Kong: Representasi Pengalaman Pekerja Rumah Tangga Migran Asal Indonesia dan Filipina di Hong Kong
Authors: Lathofani Andhika Mutiara , Eddyono Suzanna 
Published: January 2024

Indonesia dan Filipina merupakan dua negara yang banyak mengirimkan tenaga kerja perempuan di sektor rumah tangga ke luar negeri. Hong Kong merupakan salah satu tujuan para perempuan Pekerja Rumah Tangga Migran (PRTM). Rumah merupakan ranah privat tetapi di lain sisi juga menjadi tempat bekerja PRTM menyebabkan permasalahan lain, seperti kerap terjadinya kekerasan dan penyiksaan yang dilakukan oleh majikan. Penelitian ini menelaah perlindungan sosial yang didapatkan oleh PRTM dari negara asal dan tujuan serta pengalaman mereka selama di Hong Kong. Penelitian ini merupakan studi literatur menggunakan Comparative Thematic Analysis. Data-data dihimpun dari sumber sekunder yang terbit antara tahun 2019-2023 yang dapat diakses secara online dan terdiri atas 14 artikel jurnal, 11 berita, 5 video YouTube, dan masing-masing satu research report dan tesis. Hasil penelitian ini menunjukkan bahwa para PRTM asal Indonesia dan Filipina yang bekerja di Hong Kong masih rentan dan cenderung diabaikan dalam cakupan perlindungan sosial.
Kata kunci: Pekerja Rumah Tangga Migran (PRTM), Representasi Pengalaman Pekerja, Hong Kong

Abstract
Indonesia and the Philippines are among the countries that send a significant number of women to work as domestic helpers abroad. Female Migrant Domestic Workers (MDWs) often choose Hong Kong as their destination. However, the home where they work and live is a private space, which makes it difficult to address issues such as frequent violence and torture by their employers. This study aims to explore the social protection provided to MDWs by their origin and destination countries, as well as their experiences in Hong Kong. The research employs Comparative Thematic Analysis as a literature review methodology on sources published online between 2019 and 2023, comprising 14 journal articles, 11 news articles, 5 YouTube videos, and one research report and thesis each, was used as data. The findings reveal that Indonesian and Filipino MDWs in Hong Kong still face vulnerability and are often not included in social protection coverage.
Keywords: Migrant Domestic Workers (MDWs), Worker Experience, Hong Kong
Pengelolaan Sumber Daya berbasis Komunitas: Potret Penyediaan Listrik Berbasis Masyarakat di Desa Andung Biru, Kabupaten Probolinggo
Authors: Budiono Mohammad Farid , Susetiawan  
Published: January 2024

Pengelolaan energi terbarukan oleh masyarakat sering kali mengalami kegagalan. Berbagai faktor menjadi sebab, mulai dari pengelolaan yang rumit, memerlukan modal besar, hingga tantangan persaingan bisnis dengan sumber energi lainnya. Fakta tersebut menjadi dorongan studi ini untuk mengulas praktik baik sebuah pengelolaan listrik berbasis energi terbarukan atau kemudian disebut dengan Pembangkit Listrik Tenaga Mikro Hidro (PLTMH) yang eksis dan tetap berlanjut dari tahun 1993 hingga sekarang. Melalui pendekatan penelitian kualitatif, studi ini setidaknya mengungkap bahwa keberlanjutan tersebut dikarenakan terdapat beberapa proses pengelolaan yang saling berkaitan satu dengan yang lain. Pertama, PLTMH diawali dengan munculnya ide dari seorang penduduk lokal. Kedua, penemuan ide tersebut diaplikasikan dengan membangun PLTMH yang dalam perjalanannya melibatkan berbagai aktor dari dalam dan luar desa. Ketiga, pengelolaan organisasi tercermin dari dikelolanya PLTMH tersebut secara bersama-sama oleh Kelompok Tirta Pijar. Terakhir, masyarakat merespons dengan manfaat yang diterima seperti perubahan kondisi yang dialami dan keunggulan PLTMH.
Kata kunci: Energi Baru dan Terbarukan, Pemberdayaan Masyarakat, Desa Mandiri Energi, Desa Andung Biru, PLTMH
Abstract
The process of renewable energy by communities often experiences failures. Various factors contribute to this, such as from complex management, requiring substantial capital, to business competition challenges with other energy sources. These facts serve as the caused for this study to showing the best practices of renewable energy-based electricity management, specifically referred to as Micro Hydro Power Plants (PLTMH), which have been in existence and ongoing since 1993. Through a qualitative research approach, this study reveals that sustainability is due to several interconnected management processes. Firstly, PLTMH begins with the emergence of an idea from a local actor. Secondly, the implementation of this idea involves building PLTMH, which engages various actors from within and outside the village. Thirdly, organizational management is reflected in the collective management of PLTMH by the Tirta Pijar Group. Lastly, the community responds with benefits such as changes in their conditions and the advantages of PLTMH..
Key words: New and Renewable Energy, Community Empowerment, Self-Sufficient Village Energy, Andung Biru Village, Micro Hydro Power Plant (PLTMH)
Gerakan Sosial Baru: Pengolahan Sisa Bahan Organik oleh Komunitas Eco-enzyme Nusantara di Kabupaten Sleman
Authors: Rahayu Santi Nur , Prihatin Silverius Djuni 
Published: January 2024

Abstract
Tulisan ini membahas munculnya gerakan sosial baru yang dilakukan oleh komunitas Eco-enzyme Nusantara (EEN) di Kabupaten Sleman dalam memperluas edukasi dan kebermanfaatan eco-enzyme, termasuk juga menjadi salah satu alternatif penyelesaian persoalan sampah dengan mengolah sisa bahan organik menjadi cairan eco-enzyme. Dengan menggunakan konsep gerakan sosial baru, tulisan ini bertujuan menjelaskan bagaimana gerakan edukasi yang dilakukan oleh EEN Sleman kepada masyarakat luas dalam menyebarkan kebermanfaatan cairan eco-enzyme. Penelitian dilakukan dengan metode kualitatif deskriptif. Hasil penelitian menunjukkan gerakan sosial baru yang ditempuh EEN Sleman melalui kegiatan sosialisasi, memperluas keanggotaan, dan kerja sama. Kerentanan yang dihadapi komunitas EEN ini yaitu mengenai komitmen dan konsistensi anggota sebab berkegiatan dengan mengusung prinsip kerelawanan yang tentu memiliki dinamika tersendiri.
Kata kunci: Gerakan Sosial Baru, Kerja Sama, Komunitas, Sosialisasi
Abstract
This paper discusses the emergence of new social movement initiated by the Eco-enzyme Nusantara (EEN) community in Sleman Regency, aimed at expanding the education and utility of eco-enzymes, also presents an alternative solution to waste issues by processing organic waste into eco-enzyme liquid. Utilizing the concept of new social movement, this paper seeks to explain how the educational campaign conducted by EEN Sleman reaches the wider community to disseminate the utility of eco-enzyme liquid. The research employs a descriptive qualitative methodology. The research findings reveal the new social movement undertaken by EEN Sleman through socialization, membership expansion, and collaborations. Vulnerabilities faced by the EEN community include issues concerning member commitment and consistency, given that engaging in activities based on voluntary principles that inherently involves distinct dynamics.
Key word : New Social Movement, Community, Socialization, Cooperation
Influenza, síntomas y factores asociados a casos positivos
Authors: Vega-Guerrero A.L. , Juárez-Lira A. 
Published: January 2024

Introducción: La influenza es una enfermedad de distribución mundial altamente transmisible que afecta a millones de personas cada año, con una carga elevada de hospitalización y muertes. Puede desencadenar pandemias afectando a toda la población, incluso los no considerados de riesgo. El monitoreo epidemiológico permite detecciones más oportunas.
Objetivo: Establecer la relación de los casos positivos de influenza con diversos factores y características sociodemográficas de la población analizada.
Metodología: Estudio transversal que consideró 1 021 registros de casos sospechosos de influenza. Se determinaron asociaciones crudas y cálculo de la significancia estadística con la prueba Chi cuadrada.
Resultados: De los casos positivos de influenza, 63 % presentó el tipo A y el subtipo AH3 con 54 % (n= 100). Con mayor afectación en los grupos de edad de 19 a 36 y 0 a 18 años, que corresponden al 60 % de los casos positivos.
Discusión: Al igual que ocurrió en la pandemia del 2009 por el virus de influenza A H1N1, los grupos de edad afectados continúan siendo considerados de bajo riesgo y no reciben vacuna. Respecto a la sintomatología el 98 % de los casos presentó tos y 86 % fiebre, considerados como signos cardinales en la definición operacional de la enfermedad tipo influenza.
Conclusión: Es importante considerar las características que presentan los casos confirmados de influenza con base en su comportamiento poblacional; con ello, se tendrán elementos para el ajuste de las políticas públicas en salud.
Eddy Currents Assessment of Rail Cracks Using Artificial Neural Networks in a Laboratory Setup
Authors: Gutiérrez Marcelo , Fava Javier , Vorobioff Juan , Checozzi Federico , Ruch Marta , Di fiore Tomás 
Published: January 2024

Although flaws associated with rolling contact fatigue (RCF) and the corresponding traffic induced damage, which are a cause of failure in railways, have been of great concern in railway system maintenance and safety strategies in many countries for at least two decades, this serious problem has not been yet adequately tackled in the Argentine railway system. The present upgrading activities undertaken in the Argentine railway system (in infrastructure and in rolling stock) are prompting the need for R&D in non-destructive testing techniques and procedures, to satisfy requirements of the new rolling stock and to ensure safe and economic operation of passengers and cargo. RCF damage appears as surface and near surface defects and grows into cracks which in time will propagate along the running surface and through the cross-section. Eddy current testing (ET) is a very efficient in-service inspection method for this task, the near field technique being especially recommended for ferromagnetic components.
In the present paper, an artificial neural network (ANN) method for automatic classification of flaws with lift-off compensation is presented and tested. The tests consist on the ET evaluation of right angle artificial cracks on a rail calibration coupon; the depth of the cracks studied ranged from 1 to 7 mm. The technique permitted to compensate the weakening of the signals caused by the lift-off effect, allowing signal cracks classification with lift-off variations of up to 5.4 mm.
The effect of crack skewness on the ET signals is also studied. Because the RCF cracks penetrate the rail at oblique angles, (10° to 30° to the rolling surface), an additional uncertainty component is added to the experiments if calibration is made with a piece having perpendicular cracks. In order to estimate this additional uncertainty on the ANN method presented here, further tests were made with a second calibration piece with cracks at 25° to the surface. Comparison of results showed that the peak to peak amplitudes for both types of cracks are not equivalent at all the tested depths.
Boosting the energy output of an On-Grid solar PV system using a novel techniques
Authors: Kasim N. K. , Hussain H. H. , Abed A. N. 
Published: January 2024

Two techniques have been used in this study to boost energy output of an on-grid PV system. Boosting energy output is achieved by educating the PV solar system performance parameters. Planar concentrators and cooling are two techniques used to boost energy output. The current solar PV system is placed in Baghdad/Al-Taji. This work includes improving the following performance parameters: performance ratio (PR), array efficiency, array yield, electrical energy, as well as solar irradiation. All of these improvements are accomplished by improving solar irradiance using planar concentrators (made of aluminum metal) and cooling (via water). The monthly daily average of energy produced for enhanced and reference PV modules is 14.2 kWh and 11.1 kWh, respectively. The monthly daily average of the array yield to the enhanced PV modules and reference PV modules is 7.14 kWh/kWp and 5.61 kWh/kWp, respectively. The monthly daily average of solar irradiation to the enhanced and reference PV modules is 7.71kWh/m2 and 6.101kWh/m2, respectively. The monthly daily average efficiency and performance ratio of the enhanced and reference PV modules are 14.3% & 93.6%, and 13.9% & 91.1%, respectively. The maximum average monthly temperatures of the enhanced and reference PV modules are in July, at 48.5OC and 57.4OC respectively, where the ambient air temperature is 42.1OC. The novel aspect of this work is the successful optimization of the performance (PR) parameters of an on-grid PV system using the new equations. Besides from designing a novel system to improve the performance of solar PV modules of the second generation (CIGS).
Study of rheological characteristics and mechanical strength properties of natural rubber vulcanizates varying the type and content of carbon black
Authors: Kherbouche A. , Benidir A. , Bezzazi B. 
Published: January 2024

This paper presents a study about the influence of the size and content of two types of carbon black N220 and N550 with loading of 10–100 phr on the properties of the vulcanized natural rubber (NR).The mechanical characteristics such as the tensile strength, the tensile modulus, the elongation at break, the hardness, the abrasion resistance, and rheological properties of NR reinforced with carbon black were investigated. By analyzing the results of an N220 reinforced NR, the reinforcement gives improvement in tensile strengths when fillers are added up to 70 phr. However, and by referring of elongation at break, a fall of product elasticity is observed. . The increase of filler loading results a decrease in rheological properties; optimum cure time, scorch time, cure rate index (CRI). Furthermore, the increase of the filler loading leads to the increase in hardness for all the compounds. Compared the reinforcing ability of carbon black N220 scarcely inferior to carbon black N550.However, it seems that the rubber compound filled N220 or N550 gives comparable results on mechanical properties.
Total phenolics, tannin contents, antioxidant properties, protein and sensory analysis of Pleurotus ostreatus, Pleurotus citrinopileatus and Pleurotus djamor cultivated on different sawdusts
Authors: Kılıç Ceyhun , Gürgen Ayşenur , Yıldız Sibel , Can Zehra , Değirmenci Atiye 
Published: January 2024

In mushroom cultivation, it is important to be aware of the impact of the growing substrate. This study investigated the cultivation of various oyster mushrooms, including Pleurotus ostreatus, Pleurotus citrinopileatus, and Pleurotus djamor, on different types of wood sawdust. Total phenolic content, condensed tannins, antioxidant activity by ferric reducing antioxidant power assay, protein and sensory evaluations were performed in cultivated oyster mushrooms. Wood sawdust of Fagus orientalis (oriental beech), Alnus glutinosa (alder), Castanea sativa (chestnut), and Juglans regia (walnut) were used as substrate for studied mushroom type, separately. Because champignon (Agaricus bisporus) was the most consumed mushroom, it was used as control sample. Methanolic extracts of dried mushrooms were used to measure bioactive characteristics. Pleurotus ostreatus samples cultivated in Alnus glutinosa (alder) sawdust substrate had the highest antioxidant activity. The lowest antioxidant activity values were found in Pleurotus djamor cultivated in Juglans regia (walnut) wood sawdust substrate. The highest protein content was measured in Agaricus bisporus as 13,84 %. The other highest protein concentration was found in Pleurotus ostreatus cultivated in Alnus glutinosa (alder) sawdust substrate, at 13,75 %. The lowest protein concentration belonged to Pleurotus citrinopileatus cultivated in Fagus orientalis (oriental beech) sawdust substrate as 9,86 %. While Agaricus bisporus and Pleurotus ostreatus had the highest overall appreciation score, Pleurotus citrinopileatus had the lowest. It has been observed that the substrate content has an important impact on chemical and sensory properties of the oyster mushrooms. This study provides knowledge on the chemical and sensory characteristics of three different Pleurotus mushroom species cultivated on different composts.