bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism‐Associated Ophthalmopathy
Authors: Kumar Nirdesh , Das Ashmita , Kumari Nidhi , Singh Geeta , Jain Urvashi , Singh Amrita , Bodakhe Surendra H. 
Published: February 2024

AbstractVisualization is a complex‐integrated procedure of the eyes and brain that allows to see this colorful world. Hypothyroidism‐associated ophthalmopathy (HAO), often known as dry eyes, swelling around the eyes, blurred vision, glaucoma, and cataracts, are some eye‐related issues caused by hypothyroidism. Yet there is no permanent cure for hypothyroidism; taking medicine throughout life is the only solution to keep its harmful effects under control. This study used intermittent fasting (IF) and vitamin E (Vit.E) supplementation to prevent hypothyroidism‐associated ophthalmopathy. This study hypothesized that intermittent fasting‐like diet regimens and vitamin supplementation should reduce the propagation of HAO by its antioxidant potential. In the present study, experimental animals are divided into five groups: normal, hypothyroidism control, dual, Vit. E, and IF. Hypothyroidism is generated in the experimental groups by taking propylthiouracil (PTU) for 24 days while also taking IF and Vit. E supplements. The hypothyroid‐induced experimental animals demonstrated an increase in IOP and lipid peroxidation while thyroid hormone levels depicted a massive decline which is a clear denotation of the effects of the thyroid on eyes and lifestyle. Ancient Ayurveda inspires these proposed therapies and has successfully reduced all the damage to the thyroid gland and the eye.
Design of a hybrid continuous mode broadband high efficiency power amplifier based on reconfigurable devices
Authors: Zhao Shiwei , Zhang Zuqiang , Zhou Longfei , Li Linsong , Zhao Fei 
Published: February 2024

AbstractThis letter presents a design method of resistance reactance hybrid continuous power amplifier based on reconfigurable devices and CG2H40010F. The power amplifier combines resistive‐reactive inverse F‐class power amplifier (RRIFPA), resistive‐reactive J‐class power amplifier (RRJPA), and resistive‐reactive F class power amplifier (RRFPA). We utilize the principle of low‐pass filters to control the impedance of multi‐frequency harmonics, and use the reconfigurable device SMP1345‐079LF to expand the bandwidth of the power amplifier. This article designs and produces a 1–4 GHz broadband power amplifier. The simulation and measurement results show that within the entire frequency range of 1–4 GHz, the Drain efficiency is between 53.6 and 72.1, the output power is between 40.1 and 42.6 dBm, the gain is between 10.1 and 12.6 dB, and the relative bandwidth is up to 120.
Improving quantitative MRI using self‐supervised deep learning with model reinforcement: Demonstration for rapid T1 mapping
Authors: Bian Wanyu , Jang Albert , Liu Fang 
Published: February 2024

AbstractPurposeThis paper proposes a novel self‐supervised learning framework that uses model reinforcement, REference‐free LAtent map eXtraction with MOdel REinforcement (RELAX‐MORE), for accelerated quantitative MRI (qMRI) reconstruction. The proposed method uses an optimization algorithm to unroll an iterative model‐based qMRI reconstruction into a deep learning framework, enabling accelerated MR parameter maps that are highly accurate and robust.MethodsUnlike conventional deep learning methods which require large amounts of training data, RELAX‐MORE is a subject‐specific method that can be trained on single‐subject data through self‐supervised learning, making it accessible and practically applicable to many qMRI studies. Using quantitative mapping as an example, the proposed method was applied to the brain, knee and phantom data.ResultsThe proposed method generates high‐quality MR parameter maps that correct for image artifacts, removes noise, and recovers image features in regions of imperfect image conditions. Compared with other state‐of‐the‐art conventional and deep learning methods, RELAX‐MORE significantly improves efficiency, accuracy, robustness, and generalizability for rapid MR parameter mapping.ConclusionThis work demonstrates the feasibility of a new self‐supervised learning method for rapid MR parameter mapping, that is readily adaptable to the clinical translation of qMRI.
3D analytical modeling of moving‐loading induced pile‐group behavior in stratified cross‐anisotropic poroelastic water‐saturated soils based on two stage theory
Authors: Yang Shuai , Jia Mincai 
Published: February 2024

AbstractThe aim of this paper is to propose a two‐stage theory‐based analytical method for the dynamic performance of pile groups in layered poroelastic saturated cross‐anisotropic soils induced by moving loadings. Among them, the free‐field vibrational analysis of saturated soils is performed by the analytical element‐layer approach (ALEA) and Fourier transformation. Based on the free‐field response, the boundary element (BE) solution for the soil resistance at the soil‐pile interface is derived utilizing the two‐stage theory. Simultaneously, the finite element (FE) solutions for the pile shaft resistance and deformation of pile groups are derived based on the Timoshenko beam theory. Finally, the FE‐BE coupled dynamic equation for deformations and internal loadings of the soil‐pile system is obtained. Thereafter, the reliability of the proposed method is validated by comparing with existing solutions and FE data from ABAQUS. Based on the derived solutions, a comprehensive parametric study is performed to examine the effects of loading amplitude, force speed, soft soil‐layer stiffness, soil anisotropy, and pile length on the dynamic responses of pile groups.
Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems
Authors: Lawai Vannessa , Ngaini Zainab , Farooq Saba , Wahi Rafeah , Bhawani Showkat Ahmad 
Published: February 2024

AbstractMolecularly imprinted polymer (MIP) has gained wide interest among researchers due to its unique molecular recognition of the template that is suitable as a drug carrier. Therefore, the preparation and formulation of the MIP are significant to suit the needs of the intended use. Due to its significance in drug delivery, this review aims to highlight various methods in the preparation of MIP, the composition for both controlled and stimuli‐responsive drug delivery systems, and the release mechanism of the drugs. In drug delivery systems, MIP should have a sustained release performance as well as flexibility in surface modification for targeted delivery via a range of stimuli‐responses, including external stimuli (magnetic, light) and internal stimuli (pH, temperature, redox, biological). The properties of sustained release and targeted delivery of the MIP can improve the drug's therapeutic efficacy as well as the breakthrough for the tumor targeting application.
Ring‐opening (co)polymerization of cardanol glycidyl ether
Authors: Mongkhoun Emma , Charmi Gholamreza , Grier‐‐Boisgontier Justine , Niang Fato , Gomes Margot , Quienne Baptiste , Radjou Rettina , Guégan Philippe , Caillol Sylvain , Pietrasik Joanna , Illy Nicolas 
Published: February 2024

AbstractThe anionic ring‐opening copolymerization of commercially available bio‐based cardanol glycidyl ether (CGE) was investigated without any prior purification. As a first step, anionic‐ring‐opening homopolymerization was attempted through active chain‐end and monomer‐activated mechanisms. Both strategies were unsuccessful. Conversely, in a second step, the anionic alternating ring‐opening copolymerization (AAROP) of CGE with the renewable N‐acetyl homocysteine thiolactone (NHTL) was successfully carried out in the presence of a strong base. Anisole, a solvent classified as sustainable and rarely used in anionic ring‐opening polymerization, proved to be a suitable for the AAROP. This polymerization is an unusual example of synthesis of linear polyesters with cardanol‐based monomers. The copolymers were carefully characterized by 1H, 13C, COSY, HSQC, 1H‐15N NMR and MALDI‐ToF, demonstrating an alternating structure. Then, CGE was copolymerized with NHTL and another additional epoxide. The cardanol‐derived monomers enable the preparation of functionalizable poly(ester‐alt‐thioether) bearing multiple allyl and alkene groups. The AAROP method in anisole offers new opportunity for green anionic polymerization through the use of sustainable chemicals, witnessed by the valorization of cardanol‐derived compounds and expands the scope of synthesized renewable polyesters.
Novel premature termination codon in the FOXP3 gene as the cause of familial hydrops fetalis in males
Authors: Goodhue Brighton , Smith MaryLou , Bennett Kelly , Grace Matthew 
Published: February 2024

AbstractA 19‐year‐old, G1P0, pregnant person was referred at 20w2d gestation for evaluation due to non‐immune hydrops fetalis (NIHF), which was confirmed at the time of evaluation. Amniocentesis was performed at 20 w4d, and FISH, karyotype, chromosomal microarray, and exome sequencing (ES) were ordered. Trio ES identified a novel hemizygous c.142 C > T (p.Arg48*; maternally inherited) variant in the FOXP3 gene, resulting in a premature termination codon and establishing the diagnosis of immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome. Intrauterine fetal demise (IUFD) was diagnosed at 21w3d. CVS was performed at 12w1d in a subsequent pregnancy (male fetus) and the known familial variant was identified. NIHF was identified at 18w1d. Ultrasound at 19w2d revealed IUFD. This is the first report of this variant in a diagnosis of IPEX syndrome, presenting with NIHF and male fetal demise. Genotype–phenotype correlations are not available in many cases of IPEX syndrome, as the same genotype can be present with variable severity in different individuals. Given the near identical presentations in this family, we anticipate a more severe phenotype with this variant. We propose a novel variant resulting in an early premature termination codon as an explanation for the severe presentation of IPEX syndrome in two successive fetuses in this family.
The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study
Authors: Eggenhuizen Geerke M. , Go Attie T. J. I. , Sauter Zoë , Hoffer Mariëtte J. V. , Haak Monique C. , Geeven Geert , Diderich Karin E. M. , Joosten Marieke , van den Born Myrthe , Srebniak Malgorzata I. , Van Opstal Diane 
Published: February 2024

AbstractObjectiveTo evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight.MethodsCohort study using routinely collected perinatal data and cytogenetic data of non‐invasive prenatal testing, the first trimester chorionic villi sampling and postnatal placentas.Results215 CPM cases were found. Fetal growth restriction (FGR) and low birthweight below the 10th percentile (BW < p10) were seen in 34.0% and 23.1%, respectively. Excluding cases of trisomy 16, 29.1% showed FGR and 17.9% had a BW < p10. The highest rate of FGR and BW < p10 was found in CPM type 3, but differences with type 1 and 2 were not significant. FGR and BW < p10 were significantly more often observed in cases with meiotic trisomies.ConclusionThere is an association between CPM and FGR and BW < p10. This association is not restricted to trisomy 16, neither to CPM type 3, nor to CPM involving a meiotic trisomy. Pregnancies with all CPM types and origins should be considered to be at increased risk of FGR and low BW < p10. A close prenatal fetal monitoring is indicated in all cases of CPM.
Scalable all‐perovskite double‐ and triple‐junction solar modules: Modeling for configuration optimization
Authors: Takeda Yasuhiko , Yamanaka Ken‐ichi , Kato Naohiko 
Published: February 2024

AbstractWe modeled the photovoltaic conversion of all‐perovskite (PVK) double‐ and triple‐junction solar modules to clarify the configurations suitable for the monolithically series‐interconnected structure, which offers high scalability by fully exploiting the advantages of the thin‐film modules over wafer‐based crystalline‐silicon modules. We first formulated the photovoltaic processes of single cells and modules by reference to previously reported data, next optimized the module structure parameters including the bandgaps of PVKs, cell widths, and transparent‐electrode thicknesses, and then evaluated the annually averaged conversion efficiencies (ηannual) defined by the ratio of the annual energy yield to the annual insolation in outdoor environments using a meteorological database. The double‐junction four‐terminal (2J‐4T) module overcomes the shortcomings involved in the two‐terminal module consisting of series‐connected top and bottom cells, providing higher ηannual and more options of the top‐cell bandgap; the latter allows us to select a more durable PVK composition. However, the dual output (four terminals) is practically a serious drawback. The double‐junction voltage‐matched (2J‐VM) configuration eliminates this drawback, that is, realizes the single output (two terminals) with taking over the advantages of 2J‐4T, and hence, 2J‐VM would be the most promising candidate. However, when the VM configuration is applied to the triple‐junction modules, the ohmic loss and optical loss in the transparent electrodes used for the three submodules are more detrimental. To mitigate this shortcoming, we proposed a new configuration of the triple‐junction series/parallel‐connecting voltage‐matched (3J‐SPVM) module. This uses only two substrates with securing high ηannual and other advantages of the VM configuration, which contributes to cost reduction. Consequently, 3J‐SPVM is potentially the most promising configuration for widespread use.
A dyadic analysis of financial toxicity and health‐related quality of life among bone marrow transplant patients and their caregivers
Authors: Edward Jean S. , Rayens Mary Kay , McLouth Laurie E. , Eisele Lori P. , Scales Joan , Williams Lovoria B. , Hildebrandt Gerhard 
Published: February 2024

AbstractObjectiveRelatively few dyad‐based studies have evaluated the shared psychosocial and financial toxicity (FT) experiences of hematologic patients and their caregivers, especially those undergoing bone marrow transplantations (BMTs). This study evaluated the association of FT with health‐related quality of life (QOL) among BMT patient‐caregiver dyads.MethodsSurvey and electronic health record data were collected between April 2021 and January 2022 from BMT patients and their caregivers pre‐ (T1) and post‐intervention (T2). Thirty‐four patient‐caregiver dyads completed surveys; all dyads included a patient experiencing elevated T1 FT. The effect of the total FT score (i.e., the combination of psychological response, coping behaviors, and material conditions domain scores) on physical health, mental health, anxiety, depression and distress scores was evaluated using Actor‐Partner Interdependence Modeling (APIM).ResultsPatients and caregivers who reported lower total FT scores had better physical and mental health, and lower anxiety, depressive symptoms, distress (APIM actor effects). None of the partner effects were significant in the APIM models. Other model findings indicated that compared with caregivers, patients had lower reported physical health; mental health scores were higher, on average, for all participants at the T2 compared with T1; and members of dyads whose caregiver took time off work reported better physical health and lower depressive symptoms and distress than those whose caregiver did not.ConclusionsOur study addresses a significant gap in dyad‐based cancer FT studies; the findings underscore the need for additional research to help develop tailored dyad‐level FT interventions for improving health‐related QOL among BMT patients.
Mass spectrometry‐based proteomic applications in dental implants research
Authors: Halstenbach Tim , Topitsch Annika , Schilling Oliver , Iglhaut Gerhard , Nelson Katja , Fretwurst Tobias 
Published: February 2024

AbstractDental implants have been established as successful treatment options for missing teeth with steadily increasing demands. Today, the primary areas of research in dental implantology revolve around osseointegration, soft and hard tissue grafting as well as peri‐implantitis diagnostics, prevention, and treatment. This review provides a comprehensive overview of the current literature on the application of MS‐based proteomics in dental implant research, highlights how explorative proteomics provided insights into the biology of peri‐implant soft and hard tissues and how proteomics facilitated the stratification between healthy and diseased implants, enabling the identification of potential new diagnostic markers. Additionally, this review illuminates technical aspects, and provides recommendations for future study designs based on the current evidence.
Integrated plasma proteomics and N‐glycoproteomics reveals alterations in the N‐glycosylation in Chinese hepatocellular carcinoma patients
Authors: Zeng Jiaming , Rong Weiqi , Meng Bo , Zheng Linlin , Peng Tao , Zhai Rui , Jiang You , Xiao Ting , Fang Xiang , Zhang Yong , Zhao Yang , Dai Xinhua 
Published: February 2024

AbstractHepatocellular carcinoma (HCC) is a life‐threatening disease that presents diagnostic challenges due to the absence of reliable biomarkers. Recently, plasma proteomics and glycoproteomics have emerged as powerful tools for identifying potential diagnostic biomarkers for various diseases. In this study, we conducted a comprehensive proteomic and glycoproteomic analysis of plasma samples from 11 HCC patients and 11 healthy control (HC) individuals. We identified 20 differentially expressed (DE) proteins and 32 DE intact glycosylated peptides (IGPs) that can effectively differentiate between HCC patients and HC samples. Our findings demonstrate that IGP profiles had better predictive power than protein profiles for screening HCC. Pathways associated with DE proteins and IGPs were identified. It was reported that the protein expression level of galectin 3 binding protein (LGALS3BP) and its N‐linked glycosylation at the N398 and N551 sites might serve as valuable candidates for HCC diagnosis. These results highlight the importance of N‐glycoproteomics in advancing our understanding of HCC and suggest possible candidates for the future diagnosis of this disease.
In vitro and in planta investigation of succinate dehydrogenase inhibitor resistance conferred by target‐site amino acid substitutions in Puccinia horiana, chrysanthemum white rust
Authors: Matsuzaki Yuichi , Harada Toshiyuki , Iwahashi Fukumatsu 
Published: February 2024

AbstractBACKGROUNDResistance to succinate dehydrogenase inhibitor (SDHI) fungicides has been reported in some rust fungi within Pucciniales. However, measuring the resistance factors conferred by a specific substitution at the target site is difficult for most species because of the difficulty in performing in vitro experiments and the complexity of the binuclear state in these obligate parasites. We focused on Puccinia horiana because it easily forms homozygous basidiospores that are sensitive to SDHIs during in vitro germination, whereas the uredospores of other rust fungi are less sensitive.RESULTSWe identified two substitutions, SdhC‐I88F and SdhD‐C125Y, that drive SDHI resistance in Pu. horiana. Using basidiospore germination inhibition tests, we measured the resistance factors for six SDHI fungicides in Pu. horiana isolates harboring SdhC‐I88F substitutions, wherein orthologous substitutions were most frequently observed in SDHI‐resistant Pucciniales, such as soybean rust (Phakopsora pachyrhizi). The resistance factors were high for penthiopyrad and benzovindiflupyr (>150), moderate for oxycarboxin and inpyrfluxam (10–30), and low for mepronil and fluxapyroxad (3–10). The most potent SDHI against SdhC‐I88F‐harboring isolates was inpyrfluxam, with a half‐maximal effective concentration (EC50) of 0.0082 mg L−1 owing to its high intrinsic activity. SdhD‐C125Y played a minor, but significant role in increasing the resistance factors (one‐ to tenfold increases), depending on the individual SDHIs.CONCLUSIONThis study is the first to use basidiospore germination inhibitory tests to quantify the resistance factors for SDHI‐resistant Pucciniales. Owing to its homozygous binucleate nature and the high availability of basidiospores, Pu. horiana is useful for investigating SDHI resistance in Pucciniales. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Acetylcholine esterase of Drosophila melanogaster: a laboratory model to explore insecticide susceptibility gene drives
Authors: Hernandes Natalia , Qi Xiaomeng Mollyann , Bhide Soumitra , Brown Courtney , Camm Benjamin J. , Baxter Simon W. , Robin Charles 
Published: February 2024

AbstractBACKGROUNDOne of the proposed applications of gene drives has been to revert pesticide resistant mutations back to the ancestral susceptible state. Insecticides that have become ineffective because of the rise of resistance could have reinvigorated utility and be used to suppress pest populations again, perhaps at lower application doses.RESULTSWe have created a laboratory model for susceptibility gene drives that replaces field‐selected resistant variants of the acetylcholine esterase (Ace) locus of Drosophila melanogaster with ancestral susceptible variants. We constructed a CRISPR/Cas9 homing drive and found that homing occurred in many genetic backgrounds with varying efficiencies. While the drive itself could not be homozygous, it converted resistant alleles into susceptible ones and produced recessive lethal alleles that could suppress populations. Our studies provided evidence for two distinct classes of gene drive resistance (GDR): rather than being mediated by the conventional non‐homologous end‐joining (NHEJ) pathway, one seemed to involve short homologous repair and the other was defined by genetic background. Additionally, we used simulations to explore a distinct application of susceptibility drives; the use of chemicals to prevent the spread of synthetic gene drives into protected areas.CONCLUSIONSInsecticide susceptibility gene drives could be useful tools to control pest insects however problems with particularities of target loci and GDR will need to be overcome for them to be effective. Furthermore, realistic patterns of pest dispersal and high insecticide exposure rates would be required if susceptibility were to be useful as a ‘safety‐switch’ to prevent the unwanted spread of gene drives. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.