bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decolonizing social work education: Examples and reflections on inclusionary and exclusionary processes
Authors: Das Chaitali , Paschalidou Anastasia 
Published: February 2025

Abstract
This article considers issues of coloniality in social work education in Germany. As Quijano (2000) and Mignolo (2009) have identified, even though we are largely in a post-colonial context, ideas of coloniality are deeply embedded in everyday structures, institutions, and practices throughout the globe. Coloniality ensures that particular structures of power remain stable. We examine these power structures in the context of social work education in our university in Germany to exemplify and highlight some of the issues of power and inequalities that exist in the German context. We examine two social work programs at our university and use two examples to illustrate the inclusionary and exclusionary systems in place that maintain coloniality. The first example highlights how innovative educational programs and processes often end up excluding or limiting access for students from ‘non-traditional’ backgrounds. The second example highlights how the calls for widening participation in existing programs fail to open possibilities for ‘non-traditional’ students. We argue that addressing coloniality embedded in capitalistic, neo-liberal systems requires deconstructing ‘normality’ in systems, thereby identifying and disrupting paradoxes that limit widening participation and inclusion.
Right atrial thrombus in a neonate with Aspergillus colonization secondary to central venous catheter: a case report
Authors: El-Shirbiny Hassan , Ramadan Mohamed , Gomaa Mahmoud 
Published: February 2025

Abstract

Background
Central venous catheter-related thrombosis (CRT) is a recognized complication, particularly in patients with underlying hypercoagulable states. This condition can precipitate several complications, including secondary infections, necessitating immediate and effective diagnosis and management.

Case summary
In this report, we present a case of a 13-day-old neonate admitted to the neonatal intensive care unit with severe respiratory distress, necessitating the insertion of a central venous catheter for optimal nutrition and treatment. Persistent fever and worsening general condition prompted further investigations, including echocardiography, which revealed a sizeable right atrial mass. Surgical removal of the mass was performed, and subsequent analysis identified thrombosis complicated by Aspergillus colonization. Postoperative management included anticoagulation and antifungal therapy, which were continued for 3 weeks until the patient’s condition improved, leading to discharge.

Discussion
This case highlights the importance of accurate differential diagnosis of cardiac masses, early recognition and management of CRT in neonates, and the need for timely treatment of opportunistic infections like invasive Aspergillosis for optimal outcomes.
Mapping Uncharted Territory in Later Life Disablement Trajectories: A Closer Look at Progressive Disease
Authors: Johnson Samantha , Lampe Nik M , H. Nowakowski Alexandra C 
Published: February 2025

Abstract
Aging research has conceptualized disablement via two primary frameworks. Paradigms of successful aging frame substantial disablement in aging as universally abnormal. These models have often been challenged as narrow and ableist, leaving out common experiences among people with chronic conditions. By contrast, steady decline paradigms frame substantial disablement in aging as universally normal. These models have invited challenges due to ageism inherent in automatically conflating older age and disability. Both frameworks juxtapose monolithic and rigid ideas of normalcy—and thus limit our understanding of dynamic possibilities in later life health and functioning. Given that people with progressive conditions often experience wide variability in daily status and inconsistency in long-term outcomes, current later-life disablement models may overlook such experiences. We thus propose additional nuance in later-life disablement modeling that brings innovative stochastic frameworks of daily health and functioning to longitudinal trajectory concepts. Using an “aging with progressive disease perspective,” we outline gaps and opportunities in the current landscape of later-life disablement modeling. We then engage our standpoints from lived experience with progressive conditions to recommend new directions in conceptualizing relationships between aging and disability. Including such conditions in later-life disablement models can improve health care and supportive services for affected individuals.
Sudden cardiac death, arrhythmogenic cardiomyopathy and intercalated disc pathology due to reduced filamin C protein levels: a matter of life and death
Authors: Holtzhausen Christian , Heil Lorena , Klingel Karin , Fox Henrik , Gummert Jan , Gärtner Anna , Schmidt Andreas , Krüger Marcus , Kirfel Gregor , van der Ven Peter F M , Milting Hendrik , Clemen Christoph S , Schröder Rolf , Fürst Dieter O , Tiesmeier Jens 
Published: February 2025

Abstract
Mutations in the human FLNC gene encoding filamin C (FLNc) cause a broad spectrum of sporadic and familial cardiomyopathies and myopathies. We report on the genetic, clinical, morphological and biochemical findings in a German family harboring an FLNC variant that leads to severe cardiac disease comprising sudden cardiac death and arrhythmogenic cardiomyopathy. Genetic analysis identified a novel heterozygous FLNC variant in exon 16 (NM_001458.4:c.2495_2498delAGTA, het; p.K832TfsX45) in i) the index patient suffering from dilated cardiomyopathy necessitating heart transplantation, ii) a son, who died from sudden cardiac death, iii) a second son, who survived an episode of sudden cardiac arrest and iv) a third son affected by isolated skeletal muscle myopathy. FLNc protein levels were markedly reduced in cardiac tissue obtained from the index patient, implying that the p.K832TfsX45 FLNc variant most probably caused nonsense-mediated decay of the corresponding mRNA. Morphological analysis of the diseased cardiac tissue revealed extensive fibrotic remodeling, and marked degenerative changes of the contractile apparatus of cardiomyocytes and severe structural alterations of intercalated discs. Connexin-43 signal intensity at intercalated discs was diminished and FLNc labelling of myofibrils was attenuated or even absent. Proteome analyses demonstrated complex alterations of extracellular matrix and intercalated disc proteins. Our findings demonstrate that this novel, truncating FLNC mutation likely leads to haploinsufficiency, thereby causing a deleterious sequence of degenerative changes of cardiac tissue with extensive fibrotic remodeling and intercalated disc pathology as the structural basis for FLNC-related cardiomyopathy with life-threatening cardiac arrhythmias.
Almost Finiteness and Groups of Dynamical Origin
Authors: Naryshkin Petr , Petrakos Spyridon 
Published: February 2025

Abstract
We introduce the property of having good subgroups for actions of countable discrete groups on compact metrizable spaces and show that it implies comparison when the acting group is amenable. As a consequence, free actions on finite-dimensional spaces of many notable amenable groups of dynamical origin are almost finite. For instance, this applies to topological full groups of Cantor minimal systems and the Basilica group. In particular, minimal such actions give rise to classifiable crossed products.
Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to β-lactams
Authors: Jakubu Vladislav , Cechova Marketa , Musilek Martin , Malisova Lucia , Zapletalova Barbora , Zemlickova Helena 
Published: February 2025

Abstract

Background
Data from surveillance on antibiotic resistance have shown an increasing prevalence of non-enzymatic resistance (β-lactamase-negative ampicillin-resistant) to β-lactam antibiotics among H. influenzae strains in the Czech Republic. Aminopenicillins are recommended agents for non-invasive Haemophilus influenzae infections. The phenomenon of non-enzymatic resistance to β-lactams is complicated by the fact that the phenotypic detection of PBP3 with specific amino acid substitutions (rPBP3) is challenging, since rPBP3 isolates have repeatedly been demonstrated to be split by the epidemiological cut-off values (ECOFF) for aminopenicillins defined by EUCAST.

Objectives
We sought to determine whether the penicillin disc has sufficient detection ability to predict the non-enzymatic mechanism; whether other antibiotics can be used for detection; and what is the agreement between the broth microdilution and disc diffusion methods.

Methods
We undertook susceptibility testing of selected antibiotics according to EUCAST of 153 rPBP3 strains, and sequencing of the ftsI gene to determination amino acid substitutions.

Results
For a selected set of rPBP strains: (i) the detection capability for penicillin, ampicillin, cefuroxime and amoxicillin/clavulanate was found to be 91.5%, 94.4%, 89.5% and 70.6%, respectively; (ii) the categorical agreement between the disc diffusion method and the MIC for ampicillin and cefuroxime was 71.1% and 83.8%, respectively.

Conclusions
We observed better recognition of rPBP3 strains by the ampicillin disc than by the penicillin disc. There is frequently a discrepancy in the interpretation of susceptibility results between the methods used.
Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups
Authors: Tomonaga Taisuke , Higashi Hidenori , Izumi Hiroto , Nishida Chinatsu , Sato Kazuma , Nakamura Yuiko , Morimoto Toshiki , Higashi Yasuyuki , Kojima Takuma , Sakurai Kazuo , Yatera Kazuhiro , Morimoto Yasuo 
Published: February 2025

Abstract
Objectives: Microplastics have been detected in the atmosphere, raising concerns about their impact on the lungs. There have been reports on the effects of surface functional groups in evaluating the physicochemical properties of microplastics, but no reports have evaluated their chronic effects. We performed intratracheal installation in rats to evaluate the acute and chronic effects of microplastics with different surface functional groups on the lungs.
Methods: Unmodified, NH2-modified, and COOH-modified polystyrene particles with a particle size of 1 μm were intratracheally instilled into the lungs of rats. Rats were dissected at 3 days, 1 week, 1 month, 3 months, and 6 months after exposure to analyze inflammatory cells and lung injury factors in bronchoalveolar lavage fluid (BALF) and to observe histopathological findings in the lungs.
Results: A significant increase in the number of inflammatory cells in BALF was observed up to 1 week after exposure to the NH2-based modified polystyrene compared to the negative control group. A significant increase was observed 3 days after exposure, and histopathological findings in the lungs also showed an influx of inflammatory cells into the alveolar space in the acute phase, but not in the chronic phase. In in vitro studies using RAW cell lines, NH2-based modified polystyrene also induced the highest oxidative stress compared to unmodified and COOH-based modified polystyrene. Conclusions: These results suggest that these polystyrenes do not have high pulmonary toxicity, although there are differences in toxicity due to differences in surface functional groups only in the acute phase.
Workplace loneliness and job turnover: A 6-month prospective study
Authors: Sasaki Natsu , Tsuno Kanami , Kuroda Reiko , Imamura Kotaro , Eguchi Hisashi , Shimazu Akihito , Kawakami Norito 
Published: February 2025

Abstract
Objectives: This longitudinal study examined the associations of workplace loneliness with job turnover at 6-month follow-up among Japanese full-time employees.
Methods: This study employed a 6-month prospective design as part of the Employee Cohort Study in Japan (E-COCO-J). Data from wave 15 (February 2024; baseline, T1) and wave 16 (August 2024; follow-up, T2) were used. Only participants who were employed at baseline and completed the follow-up survey were included in the analysis. Workplace loneliness at T1 was measured using three scales: the Loneliness at Work Scale (LAWS), a single-item workplace loneliness scale, and a 3-item scale developed by modifying the short UCLA Loneliness Scale for workplace loneliness. Job turnover at T2 was defined based on responses indicating either leaving a job or moving to a different company within the preceding six months. Multivariable logistic regression analysis assessed the association between workplace loneliness and job turnover, adjusting for sociodemographic variables.
Results: In total, 706 employees who were employed at baseline were included in the analysis. Turnover at follow-up was observed n=47 (6.7%). Participants who experienced turnover had significantly higher baseline scores for LAWS and the 3-item scale (p=0.044 and p=0.012, respectively). In the multivariable logistic regression, all three workplace loneliness scales demonstrated similar and significant associations with turnover at follow-up.
Conclusion: Workplace loneliness leads to job turnover. Further research is needed to address the generalization and explore mechanisms of the present findings.
Validation of Amharic versions of medication adherence tools among outpatients with cardiovascular diseases: a cross-sectional study
Authors: Tegegn Henok Getachew , Wark Stuart , Tursan d'Espaignet Édouard , Spark M Joy 
Published: February 2025

Abstract

Objectives
This study aims to validate the Amharic version of the Adherence to Refills and Medication Scale (ARMS-Am) and Morisky Green Levine Scale (MGLS-Am) and compare their psychometric properties among outpatients with cardiovascular diseases (CVD) in Ethiopia.

Methods
Outpatients with CVD attending an Ethiopian general hospital were recruited for this cross-sectional study. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) on split samples, internal consistency (IC), convergent validity, known group validity (KGV), and clinical validity using area under the curve (AUC curve) based on blood pressure (BP) control were evaluated.

Key findings
There were 613 participants with a mean age of 57.6 ± 14.1; 56.6% were female. A stepwise-EFA and first-order CFA yielded a 9-item ARMS with a 3-factor solution (explaining 50% of total variance). Second-order CFA confirmed ARMS-9Am is unidimensional (overall IC, α = 0.74). There was a strong correlation (ρ = 0.74) between ARMS-9Am and MGLS-Am scores. Pill count had moderate correlation with ARMS-9Am (ρ = −0.42) and MGLS-Am (ρ = −0.32). Both tools had good KGV for discriminating between groups based on control of BP, lipids, and heart failure symptoms. Based on BP control MGLS-Am (AUC = 0.74) had lower discriminatory power than ARMS-9Am (AUC = 0.81). ARMS-9Am had good clinical validity with 87.8% specificity and 70.4% sensitivity for a score of less than 10.

Conclusion
ARMS-9Am with a cut-off point of &lt; 10 for adherence is a valid tool for measuring medication adherence for people living with CVD and had more robust psychometric properties than MGLS-Am.
Effects of Endotracheal Weight-Based Epinephrine on Pharmacokinetics and Survival in Swine With a Cardiac Arrest
Authors: Johnson Don , Blouin Dawn , Brocklehurst Karen , O’Sullivan Joseph 
Published: February 2025

ABSTRACT

Background
The aims of this study were to compare concentration maximum (Cmax), time to Cmax, area under the curve, mean concentration over 4 minutes, and frequency and time to return of spontaneous circulation (ROSC) by group.

Methods
This was a prospective, experimental study using swine. In total, 40 pigs (n = 8 per group) were assigned as follows: 0.1 mg/kg endotracheal (ET) tube, 1 mg intravenous (IV), 2 mg ET, Cardio Pulmonary Resuscitation (CPR) + defibrillation (CPR + defib), and CPR-Only. Pigs were placed in arrest for 2 minutes, CPR was then initiated for 2 minutes, and epinephrine was then administered and repeated every 4 minutes or until ROSC. Blood samples were collected over 4 minutes. Defibrillation was initiated at 3 minutes and continued every 2 minutes for 30 minutes or until ROSC. CPR + defib and CPR-Only Groups served as controls. The CPR + defib Group had defibrillations but did not receive epinephrine. The CPR-Only Group did not receive defibrillations or epinephrine.

Results and Conclusions
The Cmax and area under the curve were significantly higher in the IV Group compared to the 0.1 mg/kg ET Group (P &lt; .05). The time to Cmax was significantly longer in the 0.1 mg/kg Group than the 1 mg IV Group (P = .03). The mean concentration of the 1 mg IV Group was higher than the 0.1 mg/kg ET Group until 180 and 240 seconds. There was no significant difference between the groups relative to time to ROSC (P &gt; .05). Return of spontaneous circulation frequencies were: 0.1 mg/kg ET Group (7 of 8); 1 mg IV Group (5 of 8); and 2 mg ET Group (1 of 8), and both CPR + defib and CPR-Only (0 out of 8). This study challenges the current guidelines relative to ET epinephrine administration. Based on our ROSC data, the 0.1 mg/kg dose of epinephrine by ET should be used as a first-line intervention.
paraCell: a novel software tool for the interactive analysis and visualization of standard and dual host–parasite single-cell RNA-seq data
Authors: Agboraw Edward , Haese-Hill William , Hentzschel Franziska , Briggs Emma , Aghabi Dana , Heawood Anna , Harding Clare R , Shiels Brian , Crouch Kathryn , Somma Domenico , Otto Thomas D 
Published: February 2025

Abstract
Advances in sequencing technology have led to a dramatic increase in the number of single-cell transcriptomic datasets. In the field of parasitology, these datasets typically describe the gene expression patterns of a given parasite species at the single-cell level under experimental conditions, in specific hosts or tissues, or at different life cycle stages. However, while this wealth of available data represents a significant resource, analysing these datasets often requires expert computational skills, preventing a considerable proportion of the parasitology community from meaningfully integrating existing single-cell data into their work. Here, we present paraCell, a novel software tool that allows the user to visualize and analyse pre-loaded single-cell data without requiring any programming ability. The source code is free to allow remote installation. On our web server, we demonstrated how to visualize and re-analyse published Plasmodium and Trypanosoma datasets. We have also generated Toxoplasma–mouse and Theileria–cow scRNA-seq datasets to highlight the functionality of paraCell for pathogen–host interaction. The analysis of the data highlights the impact of the host interferon-γ response and gene expression profiles associated with disease susceptibility by these intracellular parasites, respectively.
Molecular subtypes of adamantinomatous craniopharyngiomas
Authors: An Wenhao , Li Shouwei , An Yihua , Lin Zhixiong 
Published: February 2025

Abstract
Adamantinomatous craniopharyngioma (ACP) is the most common benign tumor in the sellar region of children and originates from embryonic remnants. Owing to its unique location and frequent tight adhesion to and invasion of surrounding structures, the ACP poses significant challenges for neurosurgical treatment. Traditionally, the core treatment for ACPs has been surgical resection supplemented with radiotherapy in cases of residual or recurrent tumors. As a result, ACP classification has been based primarily on the tumor's relationship with surrounding anatomical and histological structures, guiding the selection of surgical approaches and the prevention of complications. Moreover, efforts to explore pharmacological treatments for ACP have yielded varying results across different cases, creating confusion among researchers. This variability also suggests the possibility of different molecular subtypes within ACPs, despite being driven by a single gene mutation. With advancements in molecular biological studies, such as ACP RNA sequencing, whole-exome sequencing, and methylation analysis, along with the discovery of interactions between different molecular pathways within ACP, researchers have been continuously exploring the molecular subtyping of ACP and predicting the efficacy of targeted therapies on the basis of these subtypes. This review focuses on summarizing and synthesizing the molecular mechanisms and potential subtypes of ACP, aiming to provide theoretical support for future research on the molecular subtyping of ACP.
Dietary Acid Load and Human Health: A Systematic Review and Meta-analysis of Observational Studies
Authors: Abbastabar Maryam , Mohammadi-Pirouz Zahra , Omidvar Shabnam , Bakhtiari Afsaneh , Crowe Francesca L , Sepidarkish Mahdi 
Published: February 2025

Abstract

Context
Dietary acid load (DAL) plays an important role in different aspects of human health.

Objective
The aim of this meta-analysis was to systematically synthesize the observational evidence reporting on the associations between the DAL (represented by a potential renal acid load [PRAL] and net endogenous acid production [NEAP]) and a range of health outcomes.

Data Sources
A systematic search of Medline (via PubMed), EMBASE, Scopus, and Web of Science was performed to identify eligible studies.

Data Extraction
Study screening and risk-of-bias assessment were conducted by 2 independent reviewers.

Data Analysis
The credibility of each outcome was graded based on predefined criteria: pooled effect size with corresponding 95% CI, 95% prediction interval, heterogeneity, small-study effect, and excess significance bias. In total, 118 observational studies (case-control [n = 22], cross-sectional [n = 65], and cohort [n = 31]) on 38 outcomes were included, incorporating a total population of 1 014 081 participants. Overall, 21/37 and 20/38 of the outcomes reported statistically significant effect sizes for PRAL and NEAP, respectively. The credibility of the evidence for PRAL was rated convincing (class I) for type 2 diabetes (T2D), and as highly suggestive evidence (class II) for overall cancer and systolic blood pressure. By assessing the credibility of the evidence for NEAP, T2D and overall cancer presented convincing evidence (class I) and breast cancer presented highly suggestive evidence (class II). The remaining outcomes presented class III (suggestive) or lower evidence (weak or no association).

Conclusion
The higher acid-forming potential of diet was associated with a higher risk of T2D and overall cancer. Since this meta-analysis included observational studies and some of the associations were graded as weak, caution should be exercised in interpreting these associations. Further cohort studies are required with consideration of other factors that can cause biases.

Systematic Review Registration
PROSPERO registration no. CRD42022336050.