bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of models for frictional heating in sliding isolators
Authors: Kim Hyun‐Myung , Constantinou Michael C. 
Published: December 2023

AbstractThis paper investigates the validity of theories for the prediction of the temperature increase at the sliding interfaces of sliding isolators. The prevailing theory considers the isolator to be indefinite in depth and the heat flux generated at the sliding interface(s) to be infinite in extent. In reality, the depth is finite and small, and bounded by an insulating boundary, whereas the heat flux is bound by the circular area of contact. New theories are presented in which the restrictions of the past theory are relaxed. The resulting solutions have been implemented in program OpenSees for single and for triple friction pendulum isolators but are very complex and time‐consuming to be used in response history analysis with many isolators. Analysis of the response of sliding isolated structures with these models demonstrates that consideration of the finite depth of the isolators and of the limited extent of the heat flux does not have any important effects on the calculated isolator displacement demands in either short‐duration or long‐duration ground motions. It is shown that the finite depth has some effect on the peak temperature at the sliding interface and, more importantly, on the duration of the high temperature in long‐duration ground motions. This is of some importance in the use of these theories for the development of testing specifications for isolators with unusually thin end plates.
Multi‐rate real‐time hybrid simulation with adaptive discrete feedforward controller‐based compensation strategy
Authors: Tao Junjie , Mercan Oya , Calayir Muhammet 
Published: December 2023

AbstractReal‐time hybrid simulation (RTHS) is an innovative experimental testing technique that tests only some structural components for which accurate numerical models do not exist (i.e., experimental substructure), while modeling the rest of the structure numerically (i.e., numerical substructure). Conventionally, the two substructures in RTHS are executed at the same rate and interact in real time. Multi‐rate real‐time hybrid simulation (mrRTHS) is a modification of RTHS where different time step sizes are applied to the numerical substructure computation and the actuator control. This configuration provides a larger allowance for real‐time execution, thereby enabling the use of higher‐fidelity numerical models in RTHS. However, it complicates the data transmission between the substructures and introduces an additional time delay. The increased delay consists of communication and computational delays, which are independent of actuator dynamics. This study compares the data transmission within RTHS and mrRTHS configurations and confirms that mrRTHS experiences a larger delay error. To improve the accuracy of mrRTHS, a time‐varying interpolation built with Chebyshev polynomials is used. Additionally, a compensation strategy based on an adaptive discrete feedforward controller is introduced to compensate for actuator‐induced tracking errors and the increased time delay in mrRTHS. A demonstrative experimental study is conducted to investigate the seismic behavior of a large‐scale base‐isolated structure equipped with gyromass dampers. The results indicate that the proposed mrRTHS compensation strategy facilitates a more realistic assessment of the dynamic performance of structural systems by employing higher‐fidelity numerical substructures in mrRTHS.
Green Coffee Bean Extract Assisted Facile Synthesis of Reduced Graphene Oxide and Its Dye Removal Activity
Authors: Islam A.B.M. Nazmul , Saha Prianka , Hossain Md. Emran , Habib Md. Ahsan , Karim Kaykobad Md. Rezaul , Mahiuddin Md. 
Published: December 2023

AbstractTo discharge the colored effluents from industries there needs to be effective and affordable treatment options. Adsorption using reduced graphene oxide (rGO) as an adsorbent is a prominent one. In this study, green coffee bean extract (GCBE) is utilized as a safe reducing agent for the reduction of graphene oxide (GO) to synthesize rGO. The formation of rGO is confirmed by a new peak in the UV–vis spectra at 275 nm and a diffraction peak in the XRD patterns at 22°. The effective formation of rGO is further substantiated by a change in the GO peak's properties in the FTIR, EDX, and Raman spectra and a weight loss change in TGA. The SEM and TEM analyses demonstrate the effective production of the nano‐sheets of rGO having exfoliated and segregated in a few layers. Furthermore, the obtained rGO exhibited outstanding efficacy in wastewater cleanup, effectively adsorbing MB as a prototype organic dye. The kinetics and isotherm study suggested that the adsorption leads by the chemisorption and monolayer formation on the homogeneous surface of rGO. The maximum adsorption capacity is found to be 89.3 mg g−1. This process offers a fresh opportunity for the economical and safe production of rGO for wastewater treatment.
Big Mistake: Knowing and Doing Better in Patient Engagement
Authors: Lynch Holly Fernandez 
Published: December 2023

AbstractPushing back on policies favored by dying patients is a challenging endeavor, requiring tact, engagement, openness to bidirectional learning, and willingness to offer alternative solutions. It's easy to make missteps, especially in the age of social media. Holly Fernandez Lynch shares her experience learning with and from the amyotrophic lateral sclerosis (ALS) community, first as a caricature of an ivory tower bioethicist and more recently as a trusted advisor, at least for some. Patient‐engaged bioethics doesn't mean taking the view that patients are always right, but even when disagreement continues, progress is possible if academics and patients recognize the unique expertise each has to offer.
Lnc‐ANRIL modulates the immune response associated with NF‐κB pathway in LPS‐stimulated bovine mammary epithelial cells
Authors: Lu Jinye , Gu Beibei , Lu Wei , Liu Jing , Lu Jiang 
Published: December 2023

AbstractBackgroundThe antisense noncoding RNA in the INK4 locus (ANRIL) has been confirmed related to multiple disease progression, but the role and exact mechanisms of lnc‐ANRIL in lipopolysaccharide (LPS)‐induced inflammation of bovine mammary epithelial cells (MAC‐T) remain unclear.AimsThis manuscript focused on expounding the functional role of lnc‐ANRIL through experiments performed in MAC‐T.MethodsAt the in vitro level, we established a Bovine mammary epithelial cell (BMEC) cell model of mastitis by LPS treatment. Transfection of siRNA was examined by immunofluorescence localization and RT‐qPCR. CCK8, clonogenic assay and EdU were used to detect the proliferation ability of the cells. Cell cycle and apoptosis were detected by flow cytometry and Western blot. The levels of inflammatory factors and oxidative stress markers were detected by ELISA kits.ResultsCell Counting Kit‐8, colony formation, and 5‐ethynyl‐20‐deoxyuridine were adopted and the data illustrated that LPS could significantly suppress the cell proliferation, while knockdown of lnc‐ANRIL expression obviously promoted MAC‐T cell proliferation compared with LPS or LPS + si‐NC group. Flow cytometry analysis demonstrated that lnc‐ANRIL could induce MAC‐T cell apoptosis. In addition, downregulation of lnc‐ANRIL affected LPS‐induced immune response by regulating inflammatory factor expressions and modulating the nuclear factor kappa B (NF‐κB) axis in MAC‐T cells.ConclusionOur results suggest that lnc‐ANRIL is involved in the regulation of cell proliferation, cell cycle, and cell apoptosis of MAC‐T cells, and plays an important role in the inflammatory and immune response of MAC‐T cells through the regulation of the NF‐κB pathway, proposing new therapeutic strategies for the treatment of innate immune response‐related disease such as bovine mastitis.
The establishment of a multiplex fluorescent polymerase chain reaction coupled with capillary electrophoresis analysis technology enables the simultaneous detection of 16 genotypes of human papillomavirus
Authors: Nie Lingling , Qin Haiyang , Li Sisi , Yu Zailiang , Huang Weijin , Zhang Li , Zhao Jian 
Published: December 2023

AbstractBackgroundThe detection and accurate genotyping of human papillomavirus (HPV) infection is critical for preventing and effectively treating cervical cancer.MethodsA multiplex fluorescent polymerase chain reaction (PCR) coupled with a capillary electrophoresis method was developed for the simultaneous detection of the 16 most prevalent HPV genotypes. Twenty‐five pairs of primers were ultimately selected to ensure that both E and L regions of nine HPV genotypes, as well as the E regions of seven HPV genotypes could be accurately amplified.ResultsThis method enables the simultaneous detection and differentiation of 16 HPV genotypes in a single closed‐tube reaction, accurately distinguishing products with molecular weight differences >1 bp through capillary electrophoresis. This method demonstrated exceptional accuracy, specificity, and repeatability with a detection limit of 10 copies/μL for all 16 HPV genotypes. Furthermore, 152 cervical swab specimens were obtained to compare the disparities between this approach and Cobas 4800 HPV detection method. The concordance rate and κ value were 90.1% and 0.802, respectively, indicating a high level of agreement. The established detection method was successfully applied to cervical swab specimens for determining HPV genotypes across all levels of cervical lesions, HPV52, 56, 16, and 59 were found to be most prevalent with infection rates of 10.8%, 9.1%, 6.5%, and 6.2%, respectively.ConclusionsThis study has successfully established a detection method capable of simultaneously identifying 16 HPV genotypes. This approach can be further applied to HPV vaccine research and surveillance, with the potential for broad applications.
Identification of FDA‐approved drugs that increase mevalonate kinase in hyper IgD syndrome
Authors: Politiek Frouwkje A. , Turkenburg Marjolein , Koster Janet , Ofman Rob , Waterham Hans R. 
Published: December 2023

AbstractMevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder caused by bi‐allelic loss‐of‐function variants in the MVK gene, resulting in decreased activity of the encoded mevalonate kinase (MK). Clinical presentation ranges from the severe early‐lethal mevalonic aciduria to the milder hyper‐IgD syndrome (MKD–HIDS), and is in the majority of patients associated with recurrent inflammatory episodes with often unclear cause. Previous studies with MKD–HIDS patient cells indicated that increased temperature, as caused by fever during an inflammatory episode, lowers the residual MK activity, which causes a temporary shortage of non‐sterol isoprenoids that promotes the further development of inflammation. Because an increase of the residual MK activity is expected to make MKD–HIDS patients less sensitive to developing inflammatory episodes, we established a cell‐based screen that can be used to identify compounds and/or therapeutic targets that promote this increase. Using a reporter HeLa cell line that stably expresses the most common MKD–HIDS variant, MK‐V377I, C‐terminally tagged with bioluminescent NanoLuc luciferase (nLuc), we screened the Prestwick Chemical Library®, which includes 1280 FDA‐approved compounds. Multiple compounds increased MK‐V377I‐nLuc bioluminescence, including steroids (i.e., glucocorticoids, estrogens, and progestogens), statins and antineoplastic drugs. The glucocorticoids increased MK‐V377I‐nLuc bioluminescence through glucocorticoid receptor signaling. Subsequent studies in MKD–HIDS patient cells showed that the potent glucocorticoid clobetasol propionate increases gene transcription of MVK and other genes regulated by the transcription factor sterol regulatory element‐binding protein 2 (SREBP‐2). Our results suggest that increasing the flux through the isoprenoid biosynthesis pathway by targeting the glucocorticoid receptor or SREBP‐2 could be a potential therapeutic strategy in MKD–HIDS.
Plaque Evolution and Vessel Wall Remodeling of Intracranial Arteries: A Prospective, Longitudinal Vessel Wall MRI Study
Authors: Guo Yin , Canton Gador , Baylam Geleri Duygu , Balu Niranjan , Sun Jie , Kharaji Mona , Zanaty Nadin , Wang Xin , Zhang Kaiyu , L. Tirschwell David , Hatsukami Thomas S. , Yuan Chun , Mossa‐Basha Mahmud 
Published: December 2023

BackgroundProgression of intracranial atherosclerotic disease (ICAD) is associated with ischemic stroke events and can be quantified with three‐dimensional (3D) intracranial vessel wall (IVW) MRI. However, longitudinal 3D IVW studies are limited and ICAD evolution remains relatively unknown.PurposeTo evaluate ICAD changes longitudinally and to characterize the imaging patterns of atherosclerotic plaque evolution.Study TypeProspective.Population37 patients (69 ± 12 years old, 12 females) with angiography confirmed ICAD.Field Strength/Sequence3.0T/3D time‐of‐flight gradient echo sequence and T1‐ and proton density‐weighted fast spin echo sequences.AssessmentEach patient underwent baseline and 1‐year follow‐up IVW. Then, IVW data from both time points were jointly preprocessed using a multitime point, multicontrast, and multiplanar viewing workflow (known as MOCHA). Lumen and outer wall of plaques were traced and measured, and plaques were then categorized into progression, stable, and regression groups based on changes in plaque wall thickness. Patient demographic and clinical data were collected. Culprit plaques were identified based on cerebral ischemic infarcts.Statistical TestsGeneralized estimating equations‐based linear and logistic regressions were used to assess associations between vascular risk factors, medications, luminal stenosis, IVW plaque imaging features, and longitudinal changes. A two‐sided P‐value<0.05 was considered statistically significant.ResultsDiabetes was significantly associated with ICAD progression, resulting in 6.6% decrease in lumen area and 6.7% increase in wall thickness at 1‐year follow‐up. After accounting for arterial segments, baseline contrast enhancement predicted plaque progression (odds ratio = 3.61). Culprit plaques experienced an average luminal expansion of 10.9% after 1 year. 74% of the plaques remained stable during follow‐up. The regression group (18 plaques) showed significant increase in minimum lumen area (from 7.4 to 8.3 mm2), while the progression group (13 plaques) showed significant decrease in minimum lumen area (from 5.4 to 4.3 mm2).Data ConclusionLongitudinal 3D IVW showed ICAD remodeling on the lumen side. Culprit plaques demonstrated longitudinal luminal expansion compared with their non‐culprit counterparts. Baseline plaque contrast enhancement and diabetes mellitus were found to be significantly associated with ICAD changes.Evidence Level2Technical EfficacyStage 3
Oral contact stomatitis related to toothpaste use: A report of 15 cases
Authors: Vinant M. , Agbo‐Godeau S. , Plantier F. , Quilhot P. , Bertolus C. , Bernardeschi C. 
Published: December 2023

AbstractOral contact dermatitis is an inflammatory reaction that is not common in patients but can be caused using certain toothpastes. As a result, patients experience pain, ulceration, erythema, burning sensation, vesicles and so on. Stannous fluoride is an inorganic compound used in some toothpastes for its antimicrobial, anti‐hypersensitivity and anti‐decay benefits, among others. We present a case series of 15 patients with similar types of oral lesions who all used toothpaste containing stannous fluoride, which suggested a potential association between the use of toothpaste containing stannous fluoride and oral dermatitis.
Action science in practice: Co-production of a decision support tool visualizing effects of nutrient and hypoxia reduction goals on fisheries species
Authors: Shaffer Michelle , Marriott Sara , Lewis Kristy A. , Buszowski Joe , Mutsert Kim 
Published: December 2023

Abstract

Objective
The Gulf of Mexico hosts some of the most productive fisheries in the United States, whereas the same region is known to experience environmental stressors, such as summer hypoxia. Ecosystem models have been developed for the Gulf of Mexico to determine how hypoxia affects living marine resources, but these models and their output are not always easy to access or interpret by managers, thereby decreasing their implementation in a management setting. To help alleviate the gap between ecosystem model development and management utility, the current study focuses on co-produced, user-friendly tools that describe the effects of nutrient and hypoxia reductions on marine living resources.

Methods
Two decisions were made prior to the ecosystem model development to facilitate the transfer of model output: (1) to engage and consult fisheries and restoration managers throughout ecosystem model development to ensure that the output would provide relevant information; and (2) to provide an accessible visualization tool for making ecosystem model output readily available to support the needs of decision makers.

Result
Results from an advisory panel survey instrument and advisory panel meetings guided ecosystem model development and launched the development of a decision support tool. The iterative process of building a decision support tool incorporating feedback from survey instrument respondents resulted in an ESRI ArcGIS Dashboard that allows end-users to identify the effects of hypoxia and respondent-specified nutrient and hypoxia reduction goals on the biomass and distribution of fisheries species.

Conclusion
The intent is to aid managers who are actively working to address hypoxia in the Gulf of Mexico with easy-to-access information on the effects of planned actions and to encourage future modelers to apply action science principles to best address the needs of decision makers.
Thermo‐electrohydrodynamic convection in the thermally driven spherical shell with differential rotation
Authors: Gaillard Yann , Szabo Peter S.B. , Egbers Christoph 
Published: December 2023

AbstractThis study investigates thermo‐electrohydrodynamics (TEHD) convection in the thermally driven spherical shell with differential shell rotation. The TEHD convection is induced by an electric tension applied at the inner spherical shell whereas the outer shell is grounded. Hence, an electric central force field is present similar to terrestrial gravity in a planetary system. Spherical rotation mimics planetary rotation and is used to investigate the convective nature of the spherical gap. The results demonstrate four main convective regimes that depend on the strength of the electric tension and rotational forcing. The convective pattern formation is investigated by a Hammer‐Aitov projection, the radial and meridional velocity components to indicate convective or advective fluid motion related to the individual forcing. The heat transfer is characterised by the Nusselt number and showed a strong dependence on the forcing.
Influence of fibre loading on the density, voids, dimensional resilience, tensile characteristics and thermomechanical behaviour of bamboo fibre and bio‐epoxy composites
Authors: Chandrasekar M. , Senthilkumar K. , Fouad Hassan , Jawaid Mohammad , Hashem Mohamed , Ismail Ahmad Safwan , Saba Naheed , Khiari Ramzi 
Published: December 2023

AbstractThis paper investigates the influence of bamboo fibre loadings (30, 40, 50 and 60 wt%) on the physical, tensile and dimensional behaviour of short‐bamboo‐fibre‐reinforced bio‐epoxy matrix composites. Water absorption, thickness swelling, density, void content, tensile and thermomechanical analysis were determined. The findings indicated that higher fibre loading led to elevated water absorption and increased thickness swelling in bamboo fibre composites. The order of thickness swelling and water absorption behaviour was bio‐epoxy < B‐30 < B‐40 < B‐50 < B‐60. Similarly, the measured density of composites increased with respect to fibre loading. However, the void content decreased when the fibre loading was >40 wt%. Concerning tensile characteristics, it was observed that all composite materials displayed lower tensile strength compared to the bio‐epoxy matrix. However, there was a notable enhancement in the elasticity of the composites. As an example, B‐60 exhibited the highest Young's modulus at 7.33 GPa. The analysis of the fracture behaviour of tension‐tested samples was conducted using images obtained from SEM. The coefficient of thermal expansion was increased drastically as fibre loading increased. This indicated that the dimensional change was higher. Thus, it is desirable to have lower fibre loading to obtain better dimensional stability under the influence of temperature. © 2023 Society of Industrial Chemistry.
Differential expansion and retention patterns of LRR‐RLK genes across plant evolution
Authors: Kileeg Zachary , Haldar Aparna , Khan Hasna , Qamar Arooj , Mott G. Adam 
Published: December 2023

AbstractTo maximize overall fitness, plants must accurately respond to a host of growth, developmental, and environmental signals throughout their life. Many of these internal and external signals are perceived by the leucine‐rich repeat receptor‐like kinases, which play roles in regulating growth, development, and immunity. This largest family of receptor kinases in plants can be divided into subfamilies based on the conservation of the kinase domain, which demonstrates that shared evolutionary history often indicates shared molecular function. Here we investigate the evolutionary history of this family across the evolution of 112 plant species. We identify lineage‐specific expansions of the malectin‐domain containing subfamily LRR subfamily I primarily in the Brassicales and bryophytes. Most other plant lineages instead show a large expansion in LRR subfamily XII, which in Arabidopsis is known to contain key receptors in pathogen perception. This striking asymmetric expansion may reveal a dichotomy in the evolutionary history and adaptation strategies employed by plants. A greater understanding of the evolutionary pressures and adaptation strategies acting on members of this receptor family offers a way to improve functional predictions for orphan receptors and simplify the identification of novel stress‐related receptors.
Evidence of plasma‐driven decomposition of common plastics exposed to an atmospheric nonthermal discharge
Authors: Walker Roxanne Z. , Gershman Sophia , Doughty Dorothy E. , Foster John E. 
Published: December 2023

AbstractA nonthermal, pulsed spark discharge is applied to three polymer powders in Ar and Ar– gas mixtures. Hydrogen is introduced to assess plasma‐driven decomposition. Gaseous decomposition products, including methane, acetylene, and ethylene, are observed with Fourier‐transform infrared (FTIR). Surface modifications are observed on the residual polymer via attenuated total internal reflection‐FTIR. Time‐averaged rotational, vibrational, and excitation temperatures are characterized in the discharge. The plasma density is found to be around , with rotational and vibrational temperatures ranging from 1500 to 2200 K and an excitation temperature of 1–2 eV. While spark properties did not change with either gas composition or polymer composition, it was determined that the addition of hydrogen promoted higher concentrations of gaseous phase products (promoting hydrogenolysis).