bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture
Authors: Fabrikov Dmitri , Varga Ágnes Timea , García María Carmen Vargas , Bélteky Péter , Kozma Gábor , Kónya Zoltán , López Martínez Josefa L. , Barroso Fernando , Sánchez-Muros María José 
Published: January 2024

AbstractRegulation of antibiotic use in aquaculture calls for the emergence of more sustainable alternative treatments. Tea polyphenols (GTE), particularly epigallocatechin gallate (EGCG), have various biological activities. However, tea polyphenols are susceptible to degradation. In this work, EGCG and GTE were encapsulated in zein nanoparticles (ZNP) stabilized with alginate (ALG) and chitosan (CS) to reduce the degradation effect. ALG-coated ZNP and ALG/CS-coated ZNP encapsulating EGCG or GTE were obtained with a hydrodynamic size of less than 300 nm, an absolute ζ-potential value >30 mV, and an encapsulation efficiency greater than 75%. The antioxidant capacity of the encapsulated substances, although lower than that of the free ones, maintained high levels. On the other hand, the evaluation of antimicrobial activity showed greater efficiency in terms of growth inhibition for ALG/CS-ZNP formulations, with average overall values of around 60%, reaching an inhibition of more than 90% for Photobacterium damselae. These results support encapsulation as a good strategy for tea polyphenols, as it allows maintaining significant levels of antioxidant activity and increasing the potential for antimicrobial activity, in addition to increasing protection against sources of degradation.
Potential Issues in Mandating a Disclosure of Institutional Investigation in Retraction Notices
Authors: Tang Bor Luen 
Published: January 2024

AbstractA retraction notice is a formal announcement for the removal of a paper from the literature, which is a weighty matter. Xu et al. (Science and Engineering Ethics, 29(4), 25 2023) reported that 73.7% of retraction notices indexed by the Web of Science (1927–2019) provided no information about institutional investigations that may have led to the retractions, and recommended that Committee on Publication Ethics (COPE) retraction guidelines should make it mandatory to disclose institutional investigations leading to retractions in such notices. While this recommendation would add to the transparency of the retraction process, a blanket mandate as such could be potentially problematic. For research misconduct (RM)-positive cases, a mandatory investigative disclosure may be abused by some to deflect responsibility. More importantly, a mandatory disclosure could harm authors and institutions in RM-negative cases (i.e. those stemming from honest errors with no misconduct). I illustrate with case vignettes the potential epistemic injustice and confusion that a mandate for investigation disclosure in retraction notices could incur, and suggest a more nuanced approach to its implementation.
Chitosan-loaded piperlongumine nanoparticles and kaempferol enhance the anti-cancer action of doxorubicin in targeting of Ehrlich solid adenocarcinoma: in vivo and in silico modeling study
Authors: Ibrahim Fawziya A. R. , Hussein Neveen A. , Soliman Aisha Y. M. , shalaby Thanaa I. , Rashad Mona M. , Matar Noura A. , El-Sewedy Tarek S. 
Published: January 2024

AbstractDoxorubicin is a chemotherapeutic drug that generates free radical-induced toxicities. Natural agents are used to potentiate or ameliorate the toxicity of chemotherapy. None of the studies investigating whether antioxidants or prooxidants should be used with chemotherapy have addressed their efficacy in the same study. Therefore, the aim of this study was to investigate the potential synergy between doxorubicin and two natural rarely in vivo studied anticancer agents; the antioxidant “Kaempferol” and prooxidant “Piperlongumine” in Ehrlich tumor mice model. 77 albino mice were divided into 11 groups; Ehrlich ascites carcinoma cells were injected intramuscularly to develop solid tumors. After 14 days, intratumoral injections of single or combinations of free or Chitosan nanoparticles loaded with doxorubicin, Piperlongumine, and Kaempferol were performed. Tumor Characterization of nanoparticles was measured, tumors were histopathologically examined and evaluation of expression for cancer-related genes by real-time PCR. In silico molecular docking was performed to uncover potential novel targets for Piperlongumine and Kaempferol. Despite receiving half of the overall dose compared to the free drugs, the combined doxorubicin/ piperlongumine-chitosan nanoparticles treatment was the most efficient in reducing tumor volume; down-regulating Cyclin D1, and BCL2; as well as the Beclin-1, and Cyclophilin A genes modulating growth, apoptosis, autophagy, and metastasis, respectively; up-regulating the Glutathione peroxidase expression as a defense mechanism protecting from oxidative damage. When combined with doxorubicin, Kaempferol and Piperlongumine were effective against Ehrlich solid tumors. However, the combination with the Piperlongumine-loaded chitosan nanoparticles significantly enhanced its anticancer effect compared to the Kaempferol or the same free compounds.
HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme
Authors: Yang Xiaoli , Jiang Shasha , Liu Fengjun , Li Zonghui , Liu Wenxuan , Zhang Xianjuan , Nan Fulong , Li Jun , Yu Meng , Wang Yunyang , Wang Bin 
Published: January 2024

AbstractGlioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate early protein 1 (IE1) in GBM tissues is strongly associated with their malignant progression, presenting a novel target for therapeutic strategies. Here, the bioluminescence imaging technology revealed remarkable tumor shrinkage and improved survival rates in a mouse glioma model treated with HCMV IE1/IE1mut vaccine. In addition, immunofluorescence data demonstrated that the treated group exhibited significantly more and larger tertiary lymphoid structures (TLSs) than the untreated group. The presence of TLS was associated with enhanced T cell infiltration, and a large number of proliferating T cells were found in the treated group. Furthermore, the flow cytometry results showed that in the treatment group, cytotoxic T lymphocytes exhibited partial polarization toward effector memory T cells and were activated to play a lethal role in the peripheral immunological organs. Furthermore, a substantial proportion of B cells in the draining lymph nodes expressed CD40 and CD86. Surprisingly, quantitative polymerase chain reaction indicated that a high expression of cytokines, including chemokines in brain tumors and immune tissues, induced the differentiation, development, and chemokine migration of immune cells in the treated group. Our study data demonstrate that IE1 or IE1mut vaccination has a favorable effect in glioma mice models. This study holds substantial implications for identifying new and effective therapeutic targets within GBM.
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
Authors: Lentner Theresa , Krajnik Gerhard 
Published: January 2024

SummaryA 59-year-old female patient was diagnosed with acute myeloid leukemia and tuberculosis. As a further complication, she developed idiopathic bowel perforation. Her infectious and intestinal situation demanded shorter periods of neutropenia and did not permit a high-dose, curative therapy regimen. Moreover, simultaneous administration of venetoclax and antitubercular therapy with rifampicin causes CYP3A4 interactions and thereby higher levels of toxicity. She was treated with a shortened, 14-day therapy regimen with azacitidine and venetoclax as antileukemic treatment together with ethambutol, pyrazinamide, isoniazid, and rifampicin as antitubercular therapy, which resulted in a complete remission and to an improvement of the tuberculosis without any greater toxicity or other adverse events.
Autistic traits, sensory sensitivity and eating disturbances in a sample of young adults referring to a generalized mental health clinic
Authors: Nisticò Veronica , Ingrosso Gianmarco , Lombardi Francesco , Chiudinelli Elia , Bianchini Giulia , Faggioli Raffaella , Bertani Angelo , Gambini Orsola , Demartini Benedetta 
Published: January 2024

Abstract
Purpose
The relationship between autistic traits and eating disturbances has been given considerable attention over the last decades. The rise of a dimensional approach to psychopathology has expanded the way we think about autism, acknowledging that subthreshold autistic manifestations span across the general population and are more pronounced in psychiatric patients. Here we investigated the prevalence of eating disorders and its potential relationship with autistic traits and sensory sensitivity in a group of patients who were referred for the first time to a mental health outpatient clinic, without a formal diagnosis yet.

Methods
259 young adults (between 18 and 24 years old) completed: the Eating Attitude Test (EAT-26), the Swedish Eating Assessment for Autism Spectrum Disorders (SWEAA), the Autism Quotient (AQ), the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R), and the Sensory Perception Quotient—Short Form 35 item (SPQ-SF35).

Results
23.55% of participants scored above the cut-off at the EAT-26, suggesting that they presented a risk for eating disorders and should be assessed by a specialized clinician; associations emerged between hypersensitivity in the touch and vision domain and both the EAT-26 and the SWEAA; the presence of autistic traits was largely associated with eating disturbances.

Conclusions
This study underlines the significance of the eating domain as a central psychopathological feature in the distress experienced by young adults with general psychiatric symptoms and psychological suffering; it adds evidence to the association between autistic traits and eating disorders and opens to new research questions about the role of subthreshold autistic traits in general psychopathology.
Level of evidence: Level I: Evidence obtained from experimental studies.
Overlapping Training and Roles: An Exploration of the State of Interprofessional Practice between Behavior Analysts and School Psychologists
Authors: Snyder Sara M. , Huber Heartley , Hornsby Tiffany , Leventhal Brian 
Published: January 2024

AbstractBoard certified behavior analysts (BCBAs) working in the schools often are charged with supporting students with and without disabilities who engage in challenging behavior. Meeting the unique needs of these students often requires a collaborative approach with other school-based professionals. We specifically sought to understand how behavior analysts engage in interprofessional collaboration with school psychologists (SPs), professionals who also have training to support students who engage in challenging behavior. We disseminated a survey across the United States targeting school-based BCBAs and SPs to further understand how their training and job responsibilities overlap. We also asked respondents about the extent to which they collaborate with the other professionals, modes of their collaboration, and barriers and facilitators in effective collaboration. Our findings in this exploratory study indicate BCBAs’ and SPs’ training and responsibilities do indeed overlap in relevant areas. Roles diverge in the frequency each professional participates in common educational and behavioral practices. Both groups report similar barriers when engaging in interprofessional collaboration, although BCBAs are more likely to report differing philosophies as a barrier. For both groups, findings suggest that BCBAs and SPs can find common ground if their professional colleagues indicate that they also value collaboration. Recommendations for future research and study limitations are also discussed.
Evaluation of sintered bauxite proppant for binary enhanced geothermal systems
Authors: KC Bijay , Ghazanfari Ehsan , McLennan John , Frash Luke P. , Meng Meng 
Published: January 2024

AbstractSolid granular proppant particles are widely used in oil and gas development to sustain permeability through fractures after hydraulic stimulation. Similar proppants are of interest for geothermal applications where the goal of sustaining permeability is the same, but the harsh geothermal environment risks rapid proppant degradation that will reduce fracture permeability. Here, we present proppant conductivity experiments using saw cut granite, tensile fractured granite, and aluminum control specimens packed with sintered bauxite ceramic proppants at concentrations of 0.0, 0.1, and 1.0 kg/m2. Simulated geothermal conditions included temperatures up to 130 °C and normal closure stresses up to 60 MPa. Compared to unpropped specimens, peak fracture conductivity enhancement was up to 6 orders of magnitude. At simulated geothermal conditions, proppants were able to sustain fracture conductivity over 60 h, but chemical dissolution and decreasing permeability over time were evident. Irreversible conductivity reductions with crushing and embedment of proppants during loading stages were also observed. Overall, sintered bauxite proppant remains a promising option for low-temperature binary-cycle enhanced geothermal systems.
Instability mechanism and control technology of soft rock roadways affected by mining in karst mountain area
Authors: Ma Zhenqian , Zheng Hanghang , Zhang Dongyue , Zhou Lang , Cao Juncai , Liang Xuchao , Chen Chuan 
Published: January 2024

AbstractThe deformation and damage of soft rock roadways in karst mountainous area is serious, which greatly restricts the safe and efficient mining of coal resources. To explore the instability mechanism of soft rock roadway under the influence of mining, the 226 rail cross-cut of Shanjiaoshu Coal Mine in China was taken as an engineering background. The methods of field monitoring and drilling imaging were adopted to analyze the roadway failure characteristics. In addition, the distributions of the plastic zone, surface displacement, and fracture fractal evolution characteristics of the surrounding rock for different stress wave peak and stress wave frequency are compared and analyzed using UDEC software. Then, the combined support scheme of “secondary strong bolting and grouting” is proposed to control the severe deformation of the roadway. The primary support mainly adopts short hollow grouting anchor cable to strengthen the shallow broken surrounding rock within 0–3 m. The secondary reinforced support adopts long hollow grouting anchor cable or constant resistance large deformation anchor cable to fully mobilize the bearing capacity of deep surrounding rock and to ensure the long-term stability of the roadway. On-site monitoring showed that the scheme could effectively control the severe deformation of the roadway, which also provided a reference for other similar roadway support.
A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation
Authors: Liu Jiwen , Li Da-Wei , He Xinxin , Liu Ronghua , Cheng Haojin , Su Chenglong , Chen Mengna , Wang Yonghong , Zhao Zhongsheng , Xu Hanyue , Cheng Zhangyu , Wang Zicheng , Pedentchouk Nikolai , Lea-Smith David J. , Todd Jonathan D. , Liu Xiaoshou , Zhao Meixun , Zhang Xiao-Hua 
Published: January 2024

AbstractHadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor microbiosphere. Currently, the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is unknown. Here, analyses of carbon isotope composition in a ~ 750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition, with anomalous 14C ages likely caused by seismically driven mass transport and the funneling effect of trench geomorphology. Microbial community composition and diverse enzyme activities in the upper ~ 27 cm differed from those at lower depths, probably due to sudden sediment deposition and differences in redox condition and organic matter availability. At lower depths, microbial population numbers, and composition remained relatively constant, except at some discrete depths with altered enzyme activity and microbial phyla abundance, possibly due to additional sudden sedimentation events of different magnitude. Evidence is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic populations. Such depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.
Greenhouse gas levels (CH4 and CO2) in Lagos state and Oyo state, Nigeria
Authors: Faraday Ediagbonya Thompson , Oluwabunmi Olabiyi Abosede 
Published: January 2024

AbstractThe proliferation of greenhouse gases has emerged as a grave menace to humanity. According to scientists, the concentration of these gases, particularly carbon dioxide and methane, is directly linked to the rapid pace of global warming and climate change. To investigate this matter, a study was conducted utilizing a portable gas detector to measure the levels of carbon dioxide and methane in four locations each in Ibadan and Lagos for three months. Readings were collected at each sampling site three times, with each collection period lasting 5 to 15 min. These readings were taken at intervals of 2 to 3 h over a period of 3 months, while also exploring their correlation with meteorological parameters (Temperature, wind speed and relative humidity). Farms, airports, residential areas, and dump sites were deliberately selected due to their contribution to greenhouse gas emissions. The study yielded the following mean concentrations of CO2 in Lagos: 717.67 ppm in Residential Areas, 751.78 ppm in Farmland, 743.78 ppm at the Airport, and 732.56 ppm at the Dumpsite. Similarly, the mean concentrations of CH4 were 0.14 ppm, 0.30 ppm, 0.36 ppm, and 0.45 ppm, respectively. In Ibadan, the average CO2 concentrations were 676.44 ppm in residential areas, 765.11 ppm in farms, 653.33 ppm at the airport, and 683.67 ppm at the dump site. The average CH4 concentrations were 0.08 ppm, 0.32 ppm, 0.43 ppm, and 0.30 ppm, respectively. Furthermore, significant relationships between CO2 and CH4 with meteorological parameters were observed, with R2 values of 0.200 for CO2 in Ibadan, 0.08 for CO2 in Lagos, 0.56 for CH4 in Ibadan, and 0.35 for CH4 in Lagos. Cities, farms, airports, and landfills are responsible for substantial greenhouse gas emissions. The massive release of CO2 and CH4 has resulted in profound impacts and consequences that fuel climate change. This research provides valuable insights into the issue, consequences, and mitigation strategies pertaining to the reduction and regulation of CO2 and CH4 emissions in Lagos and Ibadan, Nigeria.
miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches
Authors: Corvino A. , Reimold M. , Beyreuther E. , Brack F.-E. , Kroll F. , Pawelke J. , Schilz J. D. , Schneider M. , Schramm U. , Umlandt M. E. P. , Zeil K. , Ziegler T. , Metzkes-Ng J. 
Published: January 2024

Abstract
Laser plasma accelerators (LPAs) enable the generation of intense and short proton bunches on a micrometre scale, thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material analysis. Being spectrally broadband, laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample properties. The rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm

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for single proton bunches to allow for fast online feedback. Here we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm

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. The detector achieves a spatial resolution below 500

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m and a sensitivity of 100 mGy. The detector performance is tested at a proton therapy cyclotron and an LPA proton source. The experiments’ primary focus is the characterization of the scintillator’s ionization quenching behaviour.
The importance of Righi–Leduc heat flux to the ablative Rayleigh–Taylor instability during a laser irradiating targets
Authors: Cui Ye , Yang Xiao-Hu , Ma Yan-Yun , Zhang Guo-Bo , Xu Bi-Hao , Chen Ze-Hao , Li Ze , Shao Fu-Qiu , Zhang Jie 
Published: January 2024

Abstract
The Righi–Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh–Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi–Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10% and the amplitude during the nonlinear stage is increased by even more than 10% due to the feedback of the magnetic field, respectively. Our results reveal the importance of Righi–Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.
Virgin coconut oil (VCO) supplementation relieves symptoms and inflammation among COVID-19 positive adults: a single-blind randomized trial
Authors: Angeles-Agdeppa Imelda , Nacis Jacus S. , Dayrit Fabian M. , Tanda Keith V. 
Published: January 2024

Abstract
A clinical study conducted in 2020 showed that virgin coconut oil (VCO) has been found effective in the rapid relief of COVID-19 symptoms and normalization of the C-reactive protein (CRP) concentration among probable and suspected cases of COVID-19. This present study aimed to validate those results and to evaluate the effects of VCO among COVID-19 patients through a 28-day randomized, single-blind trial conducted among 76 SARS-CoV-2 RT-PCR (reverse transcription-polymerase chain report)-confirmed adults, with VCO given as a COVID-19 adjunct therapy. The results showed that VCO recipients were free from symptoms and had normal CRP concentrations by day 14. In comparison, participants in the control group reported relief from signs and symptoms on day 23, with normal CRP concentrations on day 25. This second study bolsters the use of VCO as an effective adjunct therapy for COVID-19-positive patients showing mild-to-moderate symptoms.