bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Fuzzy-based method for artificial reefs site selection- Case Study: Kish Island, the Persian Gulf
Authors: Kabiri Keivan , Mohammadi Maryam , Bargahi Hamid Reza , Shokri Mohammad Reza 
Published: December 2023

Abstract
Coral reefs face numerous threats from natural and anthropogenic stressors, impacting their health and associated ecosystems. This study investigates a method for optimal artificial reef (AR) deployment around Kish Island (KI) in the Persian Gulf (PG) to mitigate environmental impacts caused by marine tourism and safeguard coral reefs. Utilizing geospatial information systems (GIS) and fuzzy-based analyses, diverse criteria (such as water depth, clarity, proximity to natural reefs, and species diversity) were assessed for site selection. Data from various sources, including field observations, existing maps, and high-resolution satellite imagery, were accurately collected and processed. The method enabled us to take into account the complex and uncertain nature of the marine environment in KI and provide more precise and accurate recommendations for AR deployment. Fuzzy overlay analysis integrated these criteria, resulting in a final suitability map for AR deployment. The southeastern areas around KI emerged as highly suitable locations, considering factors like coral reefs' proximity and diving club distances. Notably, this method's application differed from prior studies, showcasing its effectiveness in assessing site suitability for AR deployment. While the study focuses on AR for marine tourism and reef conservation, its fuzzy-based approach allows flexibility in considering uncertain environmental factors, aiding in sustainable marine resource management in the PG. Overall, the fuzzy-based method presented in this study could be a valuable tool for policymakers and environmental managers in the PG to make informed decisions about AR deployment and the sustainable management of marine resources. The method can also be adapted for use in other marine environments elsewhere in the world.
Simulated Photovoltaic and Battery Connected Microgrid for Electrolysis Hydrogen Production &amp; Fuel Cell Power
Authors: Vrtis James , Ahmed Sina , Selvaraj Daisy 
Published: December 2023

Abstract
This paper analyzes the simulation of a photovoltaic and battery connected system for electrolysis hydrogen production and storage supplied hydrogen fuel cell power. All the systems stated are connected to evaluate the efficiency to power a continuously running fuel cell. The system is designed to be disconnected from the power grid and provide a continual power source for a given load. The three-day simulation evaluates how the variables limit the system performance and efficiency.
Modified IHC4 score predicts prognosis but not chemotherapy survival benefit in young women with HR-positive, HER2-negative early breast cancer: A Hospital-Based Cohort study
Authors: Liu Po-Chun , Wang Ming-Yang , Kuo Wen-Hung , Lien Huang-Chun , Lee Yi-Hsuan , Lo Chiao , Huang Chiun-Sheng 
Published: December 2023

Abstract
Background
We aimed to determine whether a modified IHC4 score has predictive and prognostic significance in young patients with hormone receptor (HR) positive- and human epidermal growth factor receptor 2 (HER2)-negative breast cancer.
Methods
Data of 230 breast cancer patients (< 40 years old, HR positive, HER2 negative, T1–3, and N0–1 microinvasion) who underwent surgery at the National Taiwan University Hospital from 2009 to 2018 were retrospectively collected. Immunohistochemical staining data were collected, and the associated modified IHC4 score was calculated. The association between patient characteristics and breast cancer events was analyzed.
Results
Prognosis at the median follow-up period of 5.66 years was better in the mIHC4 low-risk group than in the mIHC4 intermediate and high-risk groups. The hazard ratios were 10.89 (95% CI, 1.083–109.5; p = 0.043) and 18.49 (95% CI, 1.316–259.8; p = 0.031) in the intermediate and high-risk groups, respectively, compared with those in the low-risk group for the occurrence of breast cancer events. Adjuvant chemotherapy did not result in differences in breast cancer event-free survival among the three mIHC4 risk groups.
Conclusions
The modified IHC4 risk score has a prognostic value in young breast cancer patients with HR-positive and HER2-negative disease, but has no predictive value for adjuvant chemotherapy. Adjuvant chemotherapy may not be effective in this population, warranting the development of new treatment strategies in these patients.
Valtrate attenuates arrhythmia after myocardial ischemia-reperfusion via inducing N-linked glycosylation modification of LTβR to suppress TNFSF14-induced reduction of Cx43
Authors: Zhang Jing , Xiong Xiaoqi , Li Jun , Luo Changjun , Su Qiang , Hao Xin , Wu Qiang , Huang Wanzhong 
Published: December 2023

Abstract
Background
Myocardial ischemia-reperfusion (MIR)-induced arrhythmia remains a major cause of death in cardiovascular patients. The reduction of Cx43 has been known as a major inducer of arrhythmias after MIR, but the reason for the reduction of Cx43 remain largely unknown. This study aimed to find the key mechanism underlying the reduction of Cx43 after MIR and to screen out a herbal extract to attenuate arrhythmia after MIR.
Methods
The differential expressed genes in peripheral blood macrophages after MIR was analyzed using the data from several GEO datasets, followed by the identification in the peripheral blood macrophages and the serum of patients with myocardial infarction. TNFSF14 was not only increased but also associated to the injury after MIR. The toxic effects of TNFSF14 on cardiomyocytes was investigated in vitro. Valtrate was screened out from several herbal extracts. Its protection against TNFSF14-induced injury was evaluated in cardiomyocytes and animal models with MIR.
Results
Recombinant TNFSF14 protein not only suppressed cardiomyocytes’ viability, but also decreased Cx43 by stimulating the receptor LTβR. LTβR induces the competitive binding of MAX to MGA rather than the transcriptional factor c-Myc, thereby suppressing c-Myc-mediated transcription of Cx43. Valtrate promoted the N-linked glycosylation modification of LTβR, which reversed TNFSF14-induced reduction of Cx43 and attenuated arrhythmia after MIR.
Conclusion
Valtrate suppresses TNFSF14-induced reduction of Cx43 thereby attenuating arrhythmia after MIR.
Is Oblique Lumbar Interbody Fusion Superior to Minimally Invasive Transforaminal Lumbar Interbody Fusion for the Treatment of Lumbar Degenerative Disease?
Authors: Wang Fei , Xu YangJun , Zhou Xiaoyu , Zhang SongOu , Gu XiaoPeng , Zhao XiaoFeng , Xie MingHua , Zhou Ping , Lu YangHu , Che Bin 
Published: December 2023

Abstract
Study Design:
Retrospective case‒control study.
Purpose
To compare oblique lumbar interbody fusion (OLIF) and minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) approaches for the treatment of lumbar degenerative disease.
Methods
A total of 127 patients underwent single-level MIS TLIF, and 88 patients underwent OLIF with posterior bilateral percutaneous pedicle screws. Demographic characteristics, surgical information, and perioperative complications were compared between the OLIF and Mis-TLIF groups. The Visual Analog Scale (VAS), Oswestry Disability Index (ODI) and 36-Item Short Form Survey Instrument (SF-36) were administered for clinical evaluations.
Results
Patients who underwent OLIF had a significantly shorter surgery time (93.1 ± 14.6 min vs. 111.1 ± 13.5 min), lower volume of blood loss (61.1 ± 15.5 ml vs. 169.0 ± 36.4 ml), fewer fluoroscopic times (23.2 ± 7.6 times vs. 42.9 ± 5.1 times), shorter hospital stay (3.1 ± 0.7 days vs. 5.1 ± 1.0 days), and earlier time to ambulation (1.9 ± 0.6 days vs. 3.6 ± 0.8 days) than those who underwent Mis-TLIF. Significant clinical improvement was observed in terms of scores on the VAS, ODI, and SF-36 when comparing the preoperative evaluation and the final follow-up. VAS back scores, ODI scores, and SF-36 scores were not significantly different between the OLIF and Mis-TLIF groups after one year of follow-up. Five patients suffered from cage subsidence in the OLIF group, while nineteen cases of cage subsidence occurred in the Mis-TLIF group.
Conclusions
Both OLIF and MIS-TLIF were effective approaches for the treatment of lumbar degenerative diseases. The OLIF procedure has a shorter operative time, lower blood loss, earlier time to ambulation, shorter hospital stay, and lower rate of cage subsidence than the MIS-TLIF procedure. There were no significant differences in long-term clinical evaluations between the OLIF and MIS-TLIF groups. However, it is very important for spine surgeons to choose the optimal surgical approach to achieve beneficial outcomes during the treatment of lumbar degenerative diseases.
Traditional Japanese Diet Score and the Sustainable Development Goals by a Global Comparative Ecological Study
Authors: Imai Tomoko , Miyamoto Keiko , Sezaki Ayako , Kawase Fumiya , Shirai Yoshiro , Abe Chisato , Sanada Masayo , Inden Ayaka , Sugihara Norie , Honda Toshie , Sumikama Yuta , Nosaka Saya , Shimokata Hiroshi 
Published: December 2023

Abstract
Background: Reducing the environmental impact of the food supply is important for achieving Sustainable Development Goals (SDGs) worldwide. We developed the Traditional Japanese Diet Score (TJDS) and reported in a global ecological study that Japanese diet is associated with reducing obesity and extending healthy life expectancy etc. We then examined the relationship between the TJDS and environmental indicators.
Methods: Average food (g/day/capita) and energy supplies (kcal/day/capita) by country were obtained from the Food and Agriculture Organization of the United Nations Statistics Division database. The TJDS was calculated from eight food groups (beneficial food components in the Japanese diet: rice, fish, soybeans, vegetables, and eggs; food components that are relatively unused in the traditional Japanese diet: wheat, milk, and red meat) by country using tertiles, and calculated the total score from -8 to 8, with higher scores means greater adherence to the TJDS. We used Land Use (m2), Greenhouse gas (GHG) emissions 2007/2013 (kg CO2eq), Acidifying emissions (g SO2eq), Eutrophying emissions (g PO43- eq), Freshwater (L),, and water use (L) per food weight by Poore et al. as environmental indicators and multiplied these indicators by each country’s average food supply. We evaluated cross-sectional and longitudinal associations between the TJDS and environmental indicators from 2010 to 2020. This study included 151 countries with populations ≥ 1 million.
Results: Land Use (β ± standard error; -0.623 ± 0.161, p<0.001), GHG 2007 (-0.149 ± 0.057, p<0.05), GHG 2013 (-0.183 ± 0.066, p<0.01), Acidifying (-1.111 ± 0.369, p<0.01), and Water use (-405.903 ± 101.416, p<0.001) were negatively associated with TJDS, and Freshwater (45.116 ± 7.866, p<0.001) was positively associated with TJDS after controlling for energy supply and latitude in 2010. In the longitudinal analysis, Land Use (β ± standard error; -0.116 ± 0.027, p<0.001), GHG 2007 (-0.040 ± 0.010, p<0.001), GHG 2013 (-0.048 ± 0.011, p<0.001), Acidifying (-0.280 ± 0.064, p<0.001), Eutrophying (-0.132 ± 0.062, p<0.05), and Water use (-118.246 ± 22.826, p<0.001) were negatively associated with TJDS after controlling for confounders.
Conclusions: This ecological study suggests that the traditional Japanese dietary pattern might improve SDGs except Fresh water.
Alliance for Clinical Trials in Oncology (Alliance) trial A022101/NRG-GI009: A pragmatic randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: evaluating radiation, ablation, and surgery (ERASur)
Authors: Hitchcock Kathryn E , Miller Eric D. , Shi Qian , Dixon Jesse G. , Gholami Sepideh , White Sarah B. , Wu Christina , Goulet Christopher C. , George Manju , Jee Kyung-Wook , Wright Chadwick L. , Yaeger Rona , Shergill Ardaman , Hong Theodore S. , George Thomas J. , O’Reilly Eileen M. , Meyerhardt Jeffrey A. , Romesser Paul B. 
Published: December 2023

Abstract
Background: For patients with liver-confined metastatic colorectal cancer (mCRC), local therapy of isolated metastases has been associated with long-term progression-free and overall survival (OS). However, for patients with more advanced mCRC, including those with extrahepatic disease, the efficacy of local therapy is less clear although increasingly being used in clinical practice. Prospective studies to clarify the role of metastatic-directed therapies in patients with mCRC are needed.
Methods:The Evaluating Radiation, Ablation, and Surgery (ERASur) A022101/NRG-GI009 trial is a randomized, National Cancer Institute-sponsored phase III study evaluating if the addition of metastatic-directed therapy to standard of care systemic therapy improves OS in patients with newly diagnosed limited mCRC. Eligible patients require a pathologic diagnosis of CRC, have BRAF wild-type and microsatellite stable disease, and have 4 or fewer sites of metastatic disease identified on baseline imaging. Liver-only metastatic disease is not permitted. All metastatic lesions must be amenable to total ablative therapy (TAT), which includes surgical resection, microwave ablation, and/or stereotactic ablative body radiotherapy (SABR) with SABR required for at least one lesion. Patients without overt disease progression after 16-26 weeks of first-line systemic therapy will be randomized 1:1 to continuation of systemic therapy with or without TAT. The trial activated through the Cancer Trials Support Unit on January 10, 2023. The primary endpoint is OS. Secondary endpoints include event-free survival, adverse events profile, and time to local recurrence with exploratory biomarker analyses. This study requires a total of 346 evaluable patients to provide 80% power with a one-sided alpha of 0.05 to detect an improvement in OS from a median of 26 months in the control arm to 37 months in the experimental arm with a hazard ratio of 0.7. The trial uses a group sequential design with two interim analyses for futility.
Discussion: The ERASur trial employs a pragmatic interventional design to test the efficacy and safety of adding multimodality TAT to standard of care systemic therapy in patients with limited mCRC.
Mobile electronics utilisation and life satisfaction among Chinese elderly people: community participation as a mediator and social network as a moderator
Authors: Zhou Jingjing , Zhang Huahua , Ren Shaochi 
Published: December 2023

Abstract
Background
Mobile electronics utilisation by elderly people has been shown to influence their life satisfaction; however, little is known about the roles of community participation and social networks in that influence. In particular, how the influence varies according to the social network density of elderly individuals has not been determined. This study responds to these questions by tapping community participation and social networks for their potential effects on the influence of elderly people’s mobile electronics utilisation on their life satisfaction.
Methods
Data on 10,819 individuals aged 60 or above were sorted from the 2020 China Longitudinal Ageing Social Survey. SPSS22.0 software was used to conduct descriptive and correlation analyses of the data. The mediating and moderating effects were tested with the use of SPSS PROCESS macro v3.4.1.
Results
After controlling for the sample’s sex, age, hukou, ethnicity, education, marital status, personal annual income, intergenerational relationships, self-rated health and activities of daily living, we found that mobile electronics utilisation by elderly people was positively related with their life satisfaction (r = 0.049, P < 0.001); that their community participation, either charitable or self-fulfilling, mediated that correlation; and that the density of their social networks significantly moderated that correlation.
Conclusions
To improve their life satisfaction, elderly people should be further familiarised with the use of mobile electronics. In addition, the resources of families and friends, neighbourhoods and society as a whole can be enlisted to help elderly people enjoy digital life by, for instance, setting up relevant courses, providing voluntary guidance and organising age-friendly social activities.
Mechanism of drug resistance to first-line chemotherapeutics mediated by TXNDC17 in neuroblastomas
Authors: Zeng Chengong , li zhuoran , Wei Zhiqing , Chen Tingting , Wang Juan , Huang Junting , Sun Feifei , Zhu Jia , Lu Suying , Zhen Zijun 
Published: December 2023

Abstract
Purpose
The prognosis of high-risk neuroblastomas (NB) that are resistant to first-line induction chemotherapy is relatively poor. This study explored the mechanism of resistance to first-line chemotherapeutics mediated by TXNDC17 and its potential solutions in NB.
Methods
The genetic and clinical data of patients with NB were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) dataset. TXNDC17 and BECN1 expressions in NB cells were up- and downregulated by transfection with plasmids and shRNA, respectively. Autophagy-related proteins were detected by western blot. Cell viability was determined using cell proliferation and toxicity experiments. Apoptotic cells were detected using flow cytometry.
Results
Overall, 1076 pediatric and adolescent patients with NB were enrolled in this study. The 10-year overall survival (OS) rates and event-free survival (EFS) rates for the patients with mutation of BECN1 were 37.4% ± 9.1% and 34.5% ± 8.8%, respectively. For patients with mutation of TXNDC17, the 10-year OS and EFS were 41.4% ± 5.9% and 24.3% ± 5.1%, respectively, which were significantly lower than those in the unaltered group. The overexpression of BECN1 and TXNDC17 reduced NB sensitivity to cisplatin (DDP), etoposide (VP16), and cyclophosphamide (CTX). Autophagy mediated by BECN1 was regulated by TXNDC17, and this process was involved in the resistance to DDP, VP16, and CTX in NB. Suberoylanilide hydroxamic acid (SAHA) can enhance the sensitivity of NB cells to chemotherapeutics by inhibiting TXNDC17, ultimately decreasing autophagy-mediated chemoresistance.
Conclusion
Acquired resistance to first-line chemotherapeutics was associated with autophagy mediated by BECN1 and regulated by TXNDC17, which can be reversed by SAHA.
WITHDRAWN: A first fatal case of acute myeloid leukemia combined with Laribacter hongkongensis bacteremia: a case report and literature review
Authors: Mo Lishai , Lu Fei , Wu Meiqing , Luo Meiling , Li Meng 
Published: December 2023

Abstract
Background: Laribacter hongkongensiswas initially isolated from the blood and pleural fluid samples of a patient with alcoholic liver cirrhosis in Hong Kong in 2001. Despite the low isolation rate in the population at present, the mortality rate of bacteremia caused by this pathogen has reached as high as 50%. To date, no documented cases have reported the co-occurrence of acute myeloid leukemia (AML) and L. hongkongensisbacteremia.
Case Presentation: A male patient with liver cirrhosis from southern China came for a medical consultation in the Department of Hematology due to a 10-dayfever. The immunohistochemical (IHC) and Bone marrow aspiration (BMA) examination results
indicated AML, which showed improvement following one year of induction and consolidation chemotherapy. However, after the completion of the second cycle of induction chemotherapy, the patient presented with a recurring fever, reaching a body temperature of 40°C. Blood culture results suggested Gram-negative bacilli and subsequent identification using MALDI-TOF MS and 16S rRNA gene sequencing confirmed the presence of Laribacter hongkongensis. Unfortunately, the complex pathogenicity and resistance mechanisms remain unidentified, leading to fatal outcomes in our patients despite receiving meropenem treatment, which was chosen based on antimicrobial susceptibility testing (AST) results.
Conclusions: We reported the first fatal case of AML combined with L. hongkongensis bacteremia based on liver disease. Hepatic dysfunction and the consumption of freshwater fish and frogs are commonly recognized as high-risk factors for infection. Therefore, strengthening preventive measures, early identification, and the appropriate utilization of antibiotics have emerged as crucial strategies for preventing and improving infections.
Assessing the causal relationship between gut microbiota and prostate cancer: a two-sample Mendelian randomization study
Authors: Wang Yijie , Long Zhaohui , Hong Yulong , Zhou Xing , Yang Guang , Tang Cheng , Qu Genyi , Li Yuan 
Published: December 2023

Abstract
Background
Numerous studies indicate that the gut microbiome is closely associated with prostate cancer (PCa), however, owing to various confounding factors, the causal relationship between gut microbiota and PCa remains unclear.
Methods
A two-sample Mendelian randomization (MR) analysis utilized genome-wide association study (GWAS) data on the gut microbiota of 18,340 participants and GWAS summary statistics on PCa involving 46,3010 participants. Inverse variance weighted (IVW) served as the primary method, complemented by the MR-Egger method, weighted median method (WME), simple mode method (SM), and weighted mode method (WM). Finally, to confirm the robustness of the results, heterogeneity test, pleiotropy test, and leave-one-out sensitivity test were conducted.
Results
IVW analysis revealed that 12 gut microbial taxa were potentially causally associated with PCa; the genera Victivallis, Akkermansia, Odoribacter, Butyrivibrio, and the families Enterobacteriaceae, Verrucomicrobiaceae, as well as the orders Verrucomicrobiales, Enterobacteriales and the class Verrucomicrobiae, were found to be positively associated with PCa risk. Conversely, the genera Eubacterium ruminantium group, Candidatus Soleaferrea, and RuminococcaceaeUCG003 were negatively associated with PCa risk.
Conclusions
Our MR study's results support a genetically predicted causal relationship between the gut microbiota and PCa, and they identify 12 specific gut microbial taxa. These findings could offer new targets for PCa screening and treatment.
A retrospective analysis of breast cancer in pregnancy: a single center experience
Authors: Davila-Zablah Yesika , Avendano Daly , Sepulveda-Castañeda Gabriela , Sanchez-Siller Elena María , Garza-Montemayor Margarita , Marino Maria Adele 
Published: December 2023

Abstract
Purpose
This retrospective study analyzes the imaging features of pregnancy-associated breast cancer (PABC) using the 5th BI-RADS lexicon for mammography (MG), ultrasound (US), and magnetic resonance imaging (MRI).
Methods
Medical records from the Breast Imaging Center of the TecSalud healthcare system, covering October 2006 to June 2020, were comprehensively reviewed. The study targeted eligible patients, specifically women with a biopsy-confirmed diagnosis of breast cancer whose initial symptoms manifested during pregnancy or the lactation period, typically within the first year after childbirth. Clinicopathological and imaging characteristics was recorded.
Results
The study included 39 patients, 41% diagnosed during pregnancy and 59% post-pregnancy, with a median age of 34 years and a positive family history of breast cancer in 36%. Tumor sizes ranged from < 0.5 cm to > 5 cm, with 90% classified as infiltrating ductal carcinoma (IDC). High-grade tumors constituted 85%, and triple-negative breast cancers were found in 36%. Axillary metastatic lymphadenopathy was present in 72%. Imaging findings showed high sensitivity for mammography (93.7%) and ultrasound (100%), while MRI revealed masses with heterogeneous enhancement in 88%. At diagnosis, 31% had metastasis, and 20% developed metastases within the first 3 years.
Conclusion
Prompt evaluation with ultrasound and biopsy of suspicious masses is crucial in pregnant or lactating patients, with both mammography and MRI deemed as safe and complementary imaging modalities for this patient population.