bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Green Heart Project: Objectives, Design, and Methods
Authors: Bhatnagar Aruni , Keith Rachel , Yeager Ray , Riggs Daniel , Sears Clara , Bucknum Brent , Smith Ted , Fleischer Daniel , Chandler Chris , Walker Kandi L. , Hart Joy L. , Srivastava Sanjay , Turner Jay , Rai Shesh 
Published: December 2023

ABSTRACTThe Green Heart Project is a community-based trial to evaluate the effects of increasing greenery on urban environment and community health. The study was initiated in 2018 in a low-to-middle-income mixed-race residential area of nearly 28,000 residents in Louisville, KY. The 4 square mile area was surveyed for land use, population characteristics, and greenness, and assigned to 8 paired clusters of demographically- and environmentally matched “target” (T) and adjacent “control” (C), clusters. Ambient levels of ultrafine particles, ozone, oxides of nitrogen, and environmental noise were measured in each cluster. Individual-level data were acquired during in-person exams of 735 participants in Wave 1 (2018-2019) and 545 participants in Wave 2 (2021) to evaluate sociodemographic and psychosocial factors. Blood, urine, nail, and hair samples were collected to evaluate standard cardiovascular risk factors, inflammation, stress, and pollutant exposure. Cardiovascular function was assessed by measuring arterial stiffness and flow-mediated dilation. After completion of Wave 2, more than 8,000 mature, mostly evergreen, trees and shrubs were planted in the T clusters in 2022. Post planting environmental and individual-level data were collected during Wave 3 (2022) from 561 participants. We plan to continue following changes in area characteristics and participant health to evaluate the long-term impact of increasing urban greenery.
“IGF2BP1 phosphorylation regulates ribonucleoprotein condensate formation by impairing low-affinity protein and RNA interactions”
Authors: Hornegger Harald , Muratovic Adnan , Anisimova Aleksandra , Burgeois Benjamin , Spinetti Elena , Covino Roberto , Madl Tobias , Karagöz G Elif 
Published: December 2023

AbstractThe insulin-like growth factor 2 mRNA binding protein (IGF2BP1) is a conserved RNA-binding protein that regulates RNA stability, localization, and translation. IGF2BP1 is part of various ribonucleoprotein (RNP) condensates regulating RNA outputs. However, the mechanism that regulates its assembly into condensates remains unknown. Here we found, using proteomics, that IGF2BP1 phosphorylation at S181 in a disordered linker is regulated in a stress-dependent manner. Phosphomimetic mutations in two disordered linkers, S181E and Y396E, modulated RNP condensate formation by IGF2BP1 without impacting its binding affinity for RNA. Intriguingly, the S181E mutant, which lies in linker 1, impaired IGF2BP1 condensate formationin vitroand in cells, whereas a Y396E mutant in the second linker increased condensate size and dynamics. Structural approaches showed that the first linker binds RNAs nonspecifically through its RGG/RG motif, an interaction weakened in the S181E mutant. Notably, linker 2 interacts with IGF2BP1’s folded domains and these interactions were partially impaired in the Y396E mutant. Our data reveal how phosphorylation modulates low affinity interaction networks in disordered linkers to regulate RNP condensate formation.
Maternal SMARCA5 is required for major ZGA in mouse embryos
Authors: Kubinyecz Oana Nicoleta , Drage Deborah , Santos Fatima , Krueger Christel , Okkenhaug Hanneke , Catalinas Celia Alda , Eckersley-Maslin Melanie , Taubenschmid-Stowers Jasmin , Reik Wolf 
Published: December 2023

AbstractZygotic genome activation (ZGA) in mice takes place in two waves, a minor wave in the one-cell embryo, and a major wave at the two-cell stage, both accompanied by global transcriptional and epigenetic reprogramming. However, the orchestration of these reprogramming events by maternal factors deposited in the oocyte is not yet entirely understood. We and others have recently shown that epigenetic modifiers such as SMARCA5 (the main ATPase in ISWI complexes) can initiate the ZGA transcriptional programmein vitro. So far, the role of SMARCA5 in ZGAin vivohas not been addressed, as constitutive knock-out mice lacking SMARCA5 are not viable. We have overcome this limitation by using the targeted protein-depletion system Trim Away to degrade SMARCA5 in early zygotes. We further harnessed the power of single cell multi-omics (scNMT-seq) and showed that in the absence of SMARCA5, major ZGA genes fail to be upregulated at the two-cell stage. This is explained by the lower accessibility and disrupted nucleosome positioning at their promoters and distal regulatory regions, compared to wild-type embryos. In contrast, we show that global chromatin accessibility at the two-cell stage is higher in SMARCA5 depleted embryos compared to control embryos, and this is accompanied by other global structural changes involving heterochromatic regions. Our results show that SMARCA5 has a global regulatory role at the two-cell stage, which includes the control of ZGA gene promoters and distal regulatory regions.
Apollo 24/7 – A chink in Apollo Hospitals’ armour?
Authors: Sinha Abhishek , Ranajee Ranajee , Dutta Sanjib 
Published: December 2023

Learning outcomes
This case study is designed to enable students to analyze the competitive landscape of a business impacted by technological disruption; evaluate the viability of an organic growth strategy using stakeholder analysis; evaluate the revenue and cost structure of Apollo 24/7 and decide on the future investment strategy; and analyze funding strategies of traditional hospitals versus pure digital players.

Case overview/synopsis
To extend its reach, Apollo Hospitals Enterprise (Apollo Hospitals), a leading private sector brick-and-mortar hospital chain in India known for using state-of-the-art technology, launched a unified virtual mobile platform Apollo 24/7 in February 2020, 45 days into the COVID-19 pandemic. The management believed that the digital platform had a unique ecosystem that could not be replicated. The analysts were optimistic about the impact of the decision on the future performance of Apollo Hospitals, as it was expected to lead to higher penetration and increased revenue. They also anticipated the unlocking of value, as and when the venture capitalist (VC) would invest in Apollo Hospitals. However, with increasing operating expenses on account of burgeoning technological and marketing expenses, things did not seem to go going as planned. Three years later, in February 2022 after the Q3 of financial year 2023 results. Suneeta Reddy, the company’s managing director found herself pondering whether the digital platform could boost Apollo Hospitals’ profitability in addition to expanding its reach and increasing affordability when the company missed the analyst estimates. In India, which was then the second most populous country, “incremental access” and “affordability” were what mattered to the patients, However, for the investors and analysts, it was quarter-on-quarter performance. The change in the macroeconomic environment stalled the company’s plan of raising money from VCs.
Furthermore, the financing dilemma also plagued Reddy. She knew there was a difference between financing for conventional businesses that for digital businesses. She also had to take decide between short-term profitability with which investors were obsessed versus long-term sustainability, which involved taking care of stakeholders’ interests.

Complexity academic level
This case study is basically aimed at postgraduate courses and executive management courses.

Supplementary materials
Teaching notes are available for educators only.

Subject Code
CSS11: Strategy.
Continuous learning at work: the power of gamification
Authors: Torresan Stefano , Hinterhuber Andreas 
Published: December 2023

PurposeThis literature review explores the potential of gamification in workplace learning beyond formal training. The study also highlights research gaps and opportunities for scholars to develop new theories and methodologies to enhance the understanding and application of gamification in workplace learning. It provides guidance for managers to use gamification to enhance learning and engagement. Ultimately, this review presents gamification as a promising field of study to increase individual and organizational performance.Design/methodology/approachLiterature review of 6625 papers in the timeframe 1990–2020, with an update to include papers published in 2023.FindingsThis article examines the impact of gamification beyond formal learning and its potential to enhance employee productivity and well-being in the workplace. While there has been extensive research on gamification in formal learning contexts, little is known about its impact on informal learning. The study argues that the context of gamification is crucial to extending its effects and discusses the role, antecedents and consequences of game design elements in the workplace. The article also explores how the learning context relates to employee learning during work. Further research is necessary to investigate the impact of individual characteristics on work experience and performance.Research limitations/implicationsIntended contribution of the present study is the development of a theoretical framework exploring the benefits of gamification in a work context.Practical implicationsFor practicing managers, this paper shows how to use gamification to increase workplace learning and employee engagement, not just in the context of formal learning—as some companies already do today—but also systematically, in the context of informal learning.Originality/valueThis study explores the impact of gamification on informal workplace learning and emphasizes the significance of the context of gamification in extending its effects to improve individual and organizational performance.
A review and analysis of impression management with photographs in sustainability reporting
Authors: Kanbaty Majid , Hellmann Andreas , Ang Lawrence , He Liyu 
Published: December 2023

Purpose
Although photographs in sustainability reports are useful in conveying complex messages, they may also be used to manipulate the presentation of disclosures to exploit the limited cognitive processing capacity of humans. Therefore, this paper aims to examine the features of photographs aimed at capturing individuals’ attention through visual structures and evoking specific emotions through carefully chosen content. Furthermore, it examines whether such framing practice is explained by incentives for legitimizing behaviours and influencing reputation.

Design/methodology/approach
The authors conduct a content analysis of photographs in 154 sustainability reports published by US companies. The authors captured the nature of photographs, the context in which they are being used, their themes and emotional content and layout and interaction features to understand how photographs are used for attribute framing to influence information processing. Furthermore, the authors statistically examine the framing practice between companies with different characteristics to identify any patterns for the impression management use of photographs in sustainability reports.

Findings
Photographs are often large with a horizontal orientation to capture attention and show content viewed at eye level and in either medium or close-up shots to engage viewers. Furthermore, photographs are emotionally loaded with different themes such as depictions of people, technology and nature. These themes are used to predominately evoke positive emotions of awe, nurturance, pride, amusement and attachment. This practice is often used by companies in environmentally sensitive areas that have close consumer relationships or are covered controversially in the media.

Originality/value
The authors reveal reporting practices and identify photographic features that attract attention and convey emotions that go beyond aesthetic qualities. This is important because emotions conveyed through photographs can be potentially misleading and influence judgements subconsciously.
Native American victimization and resistance: an examination of uranium mining in the Northwest and Northern Plains
Authors: Fegadel Averi R. , Lynch Michael J. 
Published: December 2023

Purpose
The purpose of this study is to explore the genocidal impacts of uranium mining for Native Americans in the Northwest and Northern Plains, as well as their resistance to historical and contemporary acts of colonialism.

Design/methodology/approach
Using a case study approach, this study gathered qualitative data from various government, tribal and news sources to investigate the extent of ecological violence experienced by Native Americans specific to uranium mining processes on Spokane Indian Reservation, Pine Ridge Reservation and Wind River Reservation.

Findings
Native Americans in the Northwest and Northern Plains are victimized by the capitalism-genocide involved in uranium production. The consequences of the uranium industry boom in the 1950s–1980s has left Native Americans with degraded lands, polluted water sources and a legacy of adverse health effects, including some of the highest rates of cancer.

Social implications
The work discussed in this paper offers possibilities for collaborating with Native Americans to develop more sustainable energy options for the USA to make the necessary shift away from fossil fuels and nuclear energy.

Originality/value
Prior research has addressed the genocidal impacts of uranium mining for Native Americans in the Southwest USA and claimed these actions were direct consequences of toxic colonialism, capitalistic agendas and the treadmill of production (Fegadel, 2023). Most uranium was recovered from ore deposits within the Colorado Plateau, and most abandoned uranium mines (AUMs) are located within the same region. Tribes residing in the Northwest and Northern Plains have, however, experienced similar plights as those in the Southwest, but these issues have not been widely examined.
The entangled becoming in humanities doctoral education
Authors: Nuriler Hatice , Bengtsen Søren S.E. 
Published: December 2023

Purpose
Institutional framings of doctoral education mostly do not recognize the existential dimension of doctoral experience. This paper aims to offer an expanded understanding of experiences of doctoral researchers in the humanities with the concept of entangled becoming. This concept is developed through an existential lens by using Søren Kierkegaard’s philosophy – particularly his emphasis on emotions such as passion, anxiety and despair – and Denise Batchelor’s derived concept of vulnerable voices.

Design/methodology/approach
The conceptual framing is used for an empirical study based on ethnographic interviews with 10 doctoral researchers and supplementary observational notes from fieldwork at a university in Denmark. Two of the interview cases were selected to showcase variation across lived experiences and how doctoral researchers voice their entangled becoming.

Findings
Common experiences such as loneliness, insecurity(ies), vulnerability(ies) or passion for one’s research were identified across the interviews. On the other hand, this study shows that each doctoral journey in the humanities envelops a distinct web of entanglements, entailing distinct navigation, that makes each case a unique story and each doctoral voice a specific one.

Originality/value
Combining an existential philosophical perspective with a qualitative study, the paper offers an alternative perspective for doctoral education. It connects the humanities doctoral experience to the broader condition of human existence and the sophisticated uniqueness of each researcher’s becoming.
MicroRNA let‐7 targets BmCDK1 to regulate cell proliferation and endomitosis of silk gland in the silkworm, Bombyx mori
Authors: Wang Wei , Ji Linshengzhe , Jing Xinyuan , Zhao Ping , Xia Qingyou 
Published: December 2023

AbstractMicroRNAs play critical roles in multiple developmental processes in insects. Our previous study showed that CRISPR/Cas9‐mediated knock down of the microRNA let‐7 in silkworms increased the size of larvae and silk glands, thereby improving the silk production capacity. In this study, we elucidate the molecular mechanism underlying of let‐7 regulates growth. Identification of differentially expressed genes in response to let‐7 knock down revealed enrichment of pathways associated with cell proliferation and DNA replication. let‐7 dysregulation affected the cell cycle and proliferation of the Bombyx mori cell line BmN. Dual‐luciferase and target site mutation assays showed that BmCDK1 is a direct target gene of let‐7, with only 1 binding site on its 3′‐untranslated region. RNA interference of BmCDK1 inhibited cell proliferation, but this effect was counteracted by co‐transfection with let‐7 antagomir. Moreover, let‐7 knock down induced BmCDK1 expression and promoted cell proliferation in multiple tissues, and further induced endomitosis in the silk gland in vivo. Knock down of BmCDK1 resulted in abnormal formation of a new epidermis, and larval development was arrested at the 2nd or 3rd molt stage. Taken together, our results demonstrated that BmCDK1 is a novel target of let‐7 in cell fate determination, possessing potential for improving silk yield in silkworm.
Utilization of propionic acid bacteria in the biotransformation of soy (tofu) whey: Growth and metabolite changes
Authors: Tindjau Ricco , Chua Jian‐Yong , Liu Shao‐Quan 
Published: December 2023

AbstractSoy whey, a by‐product from the tofu and soy protein isolate industry was evaluated as a substrate for a biofortified beverage using several propionic acid bacteria (PAB). PAB growth and changes in sugars, organic acids, amino acids and isoflavones were investigated. Vitamin B12 and short‐chain fatty acid (SCFA) production were measured over time. Acidipropionibacterium acidipropionici (DSM 20272) showed the highest growth, compared to the other three PABs (Propionibacterium freudenreichii [DSM 20271 and DSM 4902], A. jensenii [DSM 20535]). Acidipropionibacterium (DSM 20272 and DSM 20535) showed the best propionic acid and acetic acid production, while P. freudenreichii produced the most succinic acid. Propionibacterium freudenreichii exhibited significant vitamin B12 production at 4.06 ± 0.28 µg/L for DSM 20271, followed by 2.58 ± 0.22 µg/L for DSM 4902. Notably, all PAB displayed strong β‐glycosidase activities evidenced by the conversion of isoflavone glycosides to isoflavone aglycones. The stark differences between Acidipropionibacterium spp. and Propionibacterium spp. indicate that the former PAB is specialized in SCFA production, while the latter PAB is better at vitamin B12 bioenrichment. This study demonstrated the possibility of employing PAB fermentation to improve SCFA and vitamin B12 content. This can open avenues for a beverage or functional ingredient development.
Current applications and future trends of artificial senses in fish freshness determination: A review
Authors: Madhubhashini M. Nerandi , Liyanage Chamara P. , Alahakoon Amali U. , Liyanage Rumesh Prasanga 
Published: December 2023

AbstractFish is a highly demanding food product and the determination of fish freshness is crucial as it is a fundamental factor in fish quality. Therefore, the fishery industry has been working on developing rapid fish freshness determination methods to monitor freshness levels. Artificial senses that mimic human senses are developed as convenient emerging technologies for fish freshness determination. Computer vision, electronic nose (e‐nose), and electronic tongue (e‐tongue) are the emerging artificial senses for fish freshness determination. This review article is uniquely worked upon to investigate the current applications of the artificial senses in fish freshness determination while describing the steps, and fundamental principles behind each artificial sense, comparing them with their advantages and limitations, and future trends related to fish freshness determination. Among the artificial senses, computer vision determines the freshness of fish in a completely nondestructive way while the e‐tongue determines the freshness of fish in a completely destructive way. There are developed e‐noses for fish freshness determination in both destructive and nondestructive ways. By analyzing visual cues such as color, computer vision systems can assess fish quality without the need for physical contact and it makes computer vision suitable for large‐scale industrial fish quality assessing applications. Overall, this review study reveals artificial senses as a proven replacement for traditional sensory panels in determining fish freshness precisely and conveniently. As future trends, there is a demand for developing applications for consumers to determine fish freshness based on artificial senses.
Utility of survivorship care plans: A mixed‐method study exploring general practitioners’ and cancer specialists’ views
Authors: Tan Sim Yee , Dhillon Haryana M. , Mak Channel , Liang Roger , Kerin‐Ayres Kim , Vuong Kylie , Malalasekera Ashanya , Vardy Janette L. 
Published: December 2023

AbstractPurposeSurvivorship care plans (SCP) are recommended as integral to survivorship care but are not routinely provided in many centers. We explore whether SCP from the Sydney Cancer Survivorship Centre (SCSC) clinic was received by general practitioners (GP) and cancer specialists, and their views on SCP.MethodsA mixed‐method study comprising a quality assurance audit, a questionnaire of GP practices and GP, and semi‐structured interviews of cancer specialists who referred patients to the SCSC clinic between 2019–2020. Descriptive statistics were used for quantitative data and content analysis for qualitative data.ResultsThe audit found 153/190 (80.5%) SCSC attendees had SCP uploaded to hospital medical records. The response rate from GP practices was 41%; among the 55 responding practices, 38 (69%) did not receive the SCP. The response rate from GP was 19%; among the 29 responding GP, 25 (86%) indicated the SCP was worthwhile, especially follow‐up plans and multidisciplinary team recommendations. Analysis of 14 cancer specialist interviews identified themes of 1) awareness of SCP; 2) access: SCP difficult to locate; 3) process: access and distribution require improvement; 4) systemic issues; 5) content and layout: more concise and better readability required; 6) value: mainly for GP and survivors; 7) use of SCP: limited; 8) recommendations: improve delivery process, enhance layout/content, more stakeholder input, more tailored information.ConclusionAlthough response rates from GP were low, those responding perceived SCP to be useful. Cancer specialists believed SCP were more valuable for GP and survivors. Process issues, especially SCP delivery, need to be improved.