bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging
Authors: Manuel Jorge , Halbe Eva , Ewald Ann Charlotte , Hoff Alex , Jordan Jens , Tank Jens , Heusser Karsten , Gerlach Darius A. 
Published: December 2023

IntroductionHypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic functional connectivity changes during glucose loading using functional magnetic resonance imaging (fMRI).MethodsTo do so, we conducted oral glucose tolerance tests while acquiring functional images before, and 10 and 45 min after glucose ingestion in a healthy male and cross-sectionally in 20 healthy participants on two different diets.ResultsAt group level, 39 fMRI sessions were not sufficient to detect glucose-mediated connectivity changes. However, 10 repeated sessions in a single subject revealed significant intrinsic functional connectivity increases 45 min after glucose intake in the arcuate, paraventricular, and dorsomedial nuclei, as well as in the posterior hypothalamic area, median eminence, and mammillary bodies.DiscussionOur methodology allowed to outline glucose-sensitive hypothalamic pathways in a single human being and holds promise in delineating individual pathophysiology mechanisms in patients with dysglycemia.
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Authors: Sampogna Gaia , Luciano Mario , Di Vincenzo Matteo , Toni Claudia , D’Ambrosio Enrico , Rampino Antonio , Rossi Alessandro , Rossi Rodolfo , Amore Mario , Calcagno Pietro , Siracusano Alberto , Niolu Cinzia , Dell’Osso Liliana , Carpita Barbara ,   LIFESTYLE Working Group, Fiorillo Andrea 
Published: December 2023

Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders.Methods: In this paper, based on the LIFESTYLE randomized, controlled multicentric trial, we aim to: 1) assess the level of adherence in a real-world sample of patients with severe mental disorders; 2) evaluate differences in treatment adherence according to patients’ socio-demographic and clinical characteristics; 3) evaluate the impact of an innovative psychosocial intervention, on patients’ adherence to treatments. The Lifestyle Psychosocial Group Intervention consists of group sessions, focused on different lifestyle behaviours, including healthy diet; physical activity; smoking habits; medication adherence; risky behaviours; and regular circadian rhythms. At end of each session a 20-min moderate physical activity is performed by the whole group.Results: The sample consists of 402 patients, mainly female (57.1%, N = 229), with a mean age of 45.6 years (±11.8). Less than 40% of patients reported a good adherence to pharmacological treatments. Adherence to treatments was not influenced by gender, age, diagnosis and duration of illness. At the end of the intervention, patients receiving the experimental intervention reported a significant improvement in the levels of adherence to treatments (T0: 35.8% vs. T3: 47.6%, p &lt; 0.005). Patients practicing moderate physical activity reported a two-point improvement in the levels of adherence [odds ratio (OR): 1,542; 95% confidence intervals (CI): 1,157–2,055; p &lt; 0.001], even after controlling for several confounding factors.Discussion: The experimental lifestyle intervention, which can be easily implemented in the routine clinical practice of mental health centres, was effective in improving adherence to pharmacological treatments.
Effectiveness of compassion-based online therapy on suicidal thoughts and pain catastrophizing in female patients with multiple sclerosis in the relapsing–remitting phase
Authors: Mohamadpour Fahimeh 
Published: December 2023

IntroductionAccording to research, multiple sclerosis is related to suicidal thoughts and pain catastrophizing as psycho-pathological variables, and on the other hand, compassion-based treatment can reduce mental disorders by targeting dimensions such as self-compassion. Also, since this disease is progressive and over time can cause movement restrictions in these people, online psychotherapy can be a better option for these people. So, the purpose of this study was to investigate the effectiveness of online compassion therapy on suicidal thoughts and pain catastrophizing in female patients with multiple sclerosis.MethodsThe current research was applied and quasi-experimental in a pre-test-post-test manner with a control group. The research sample consisted of 30 patients with multiple sclerosis living in Shiraz in 2019, who were randomly divided into two 15-person experimental and control groups. The participants were tested on scales of suicidal thoughts and pain catastrophizing, and the treatment plan based on compassion therapy was presented to the participants of the experimental group in 8 two-hour sessions online. The control group was placed on the waiting list until the completion of the treatment sessions and the post-test implementation, and after the post-test implementation, they received the treatment. Control variables in this study included gender and disease phase. Then, their scores were measured, after completing the treatment, and a three-month follow-up period. Descriptive statistics and covariance test were used to analyze the data.ResultsPatients showed a clear improvement in the severity of symptoms in both variables. So that the scores of suicidal thoughts and pain catastrophizing in the experimental group after receiving the treatment, as well as after a three-month follow-up period, were significantly reduced (p &lt; 0.001).ConclusionConfirming the effectiveness of online therapy based on compassion on improving psychological outcomes in these patients, as an effective and online treatment method, is a clear step towards continuing the implementation of psychological interventions and paying attention to the dimension of mental health in this group of people.
Twenty years of emotional-behavioral problems of community adolescents living in Italy measured through the Achenbach system of empirically based assessment (ASEBA): a systematic review and meta-analysis
Authors: Pace Cecilia Serena , Muzi Stefania , Frigerio Alessandra , Morganti Wanda , Bianchi Victoria , Rogier Guyonne 
Published: December 2023

BackgroundThis is a systematic review and meta-analysis of emotional and behavioral problems among Italian community adolescents in the last 20 years, as assessed through the ASEBA questionnaires CBCL 6–18, YSR 11–18 and TRF 6–18. Research questions address: (1) pooled means of problems’ scores in questionnaires scales; (2–3) variations in scores according to sociodemographic and time-related factors, and studies’ quality; (4) trends in research with ASEBA instruments along with other outcomes, e.g., psychopathological symptoms.MethodsA systematic literature review of Scopus, EBSCO, PubMed, Web of Science, and ProQuest databases using the PRISMA 2020 guidelines was conducted on November, 2021, and of grey literature on December, 2021. The quality of studies was assessed through the Newcastle-Ottawa Scale.ResultsForty-four studies were eligible for the systematic review, of which 34 were included for meta-analysis. Results showed that: (1) emotional-behavioral problems were higher when assessed by the CBCL and lower when assessed by the YSR compared to normative data; (2) there were no gender and age differences, except for higher scores of Anxious/Depression symptoms, in girls. (3) internalizing and attention problems increased over the last two decades. (4) major trends of Italian research investigate adolescents’ emotional behavioral problems concerning attachment, comorbid symptoms, especially internet addictions, and eating disorders.DiscussionDespite some limitations (e.g., low-medium quality of most studies, no data on the TRF, under-representation of some geographical areas, some search-related choices), these data provides Italian practitioners and international researchers of some parameter to evaluate Italian adolescents emotional-behavioral problems. Registered on PROSPERO N. CRD42022299999.
Risk factors of oncogenic HPV infection in HIV-positive men with anal condyloma acuminata in Shenzhen, Southeast China: a retrospective cohort study
Authors: Liu Jiaxin , Yang Rongqing , Zhao Xiaobao , Chu Wenzhu , Li Dapeng , Wang Fuxiang , Wei Lanlan 
Published: December 2023

BackgroundHuman immunodeficiency virus (HIV)-positive patients with anal condyloma acuminata (CA) present an increased risk of anal cancer progression associated with oncogenic human papillomavirus (HPV) infection. It is essential to explore determinants of anal infection by oncogenic HPV among HIV-positive patients with CA.MethodsA retrospective cohort study was performed in HIV-positive patients with CA between January 2019 to October 2021 in Shenzhen, Southeast China. Exfoliated cells were collected from CA lesions and the anal canal of HPV genotypes detected by fluorescence PCR. Unconditional logistic regression analysis was used to probe associations of independent variables with oncogenic HPV infection.ResultsAmong HIV-positive patients with CA, the most prevalent oncogenic genotypes were HPV52 (29.43%), HPV16 (28.93%), HPV59 (19.20%), and HPV18 (15.96%). Risk of oncogenic HPV infection increased with age at enrollment (COR: 1.04, 95% CI: 1.01–1.07, p = 0.022). In the multivariable analysis, age ≥ 35 years (AOR: 2.56, 95% CI: 1.20–5.70, p = 0.02) and history of syphilis (AOR: 3.46, 95% CI: 1.90–6.79, p &lt; 0.01) were independent risk factors statistically associated with oncogenic HPV infection. History of syphilis (AOR: 1.72, 95% CI: 1.08–2.73, p &lt; 0.02) was also an independent risk factor statistically associated with HPV16 or HPV18 infection.ConclusionIn clinical practice, HIV-positive CA patients aged ≥35 years or with a history of syphilis should carry out HR-HPV testing and even anal cancer-related examinations to prevent the occurrence of anal cancer.
Racial disparities affect the association between gestational urinary phthalate mixtures and infant genital measures
Authors: Varde Meghana , Newman Roger B. , Wenzel Abby G. , Kucklick John R. , Wineland Rebecca J. , Brock John W. , Bloom Michael S. 
Published: December 2023

BackgroundPhthalates are ubiquitous anti-androgenic endocrine disrupting chemicals found in personal care products, medications, and many plastics. Studies have shown a racial disparity in phthalates exposure among U.S. women, which may also impact fetal development.MethodsWe conducted a prospective cohort study of gestational exposure to a phthalates mixture in a racially-diverse population to determine their association with genital development. Mid-gestation (18–22 weeks) urine was collected from 152 women who self-identified as non-Hispanic Black and 158 women who self-identified as non-Hispanic White in Charleston, South Carolina between 2011 and 2014. We measured eight phthalate monoester metabolites in urine using liquid chromatography tandem-mass spectrometry. Mid-gestational penile dimensions were measured using ultrasound and anogenital distances were measured postnatally. We used Bayesian kernel machine regression to estimate the associations among the mixture of phthalate metabolites and mid-gestation penile dimensions and postnatal anogenital distance measures among singleton male (n = 179) and female (n = 131) infants, adjusted for urinary specific gravity, maternal age, body mass index, education level, cigarette smoking, and gestational age at enrollment or birth weight z-score.ResultsWe found a stronger association between greater phthalates and decreased anopenile distance among infants born to women who self-identified as Black. Mono (2-ethylhexyl) phthalate (MEHP) was the driving mixture component among Black women, and monobutyl phthalate (MBP) and monoethyl phthalate (MEP) were drivers among White women. We also identified a non-linear association between phthalates and lesser ultrasound penile volume among women who self-identified as Black with monoisobutyl phthalate (MiBP) and MBP being most important. We also found an association between greater phthalates and shorter anoclitoral distance among infants born to women who self-identified as Black, with MEP and monobenzyl phthalate (MBzP) contributing most to this association.ConclusionOur results suggest a disparity in the association between gestational exposure to a mixture of phthalates and fetal genital development among women who self-identified as Black compared to White.
Exercised-based cardiac rehabilitation associates with lower all-cause mortality in patients with primary pulmonary hypertension
Authors: Kleinnibbelink Geert , Buckley Benjamin J. R. , Harrison Stephanie L. , Williams Nefyn , Fazio-Eynullayeva Elnara , Underhill Paula , van Dijk Arie P. J. , Lip Gregory Y. H. , Thijssen Dick H. J. 
Published: December 2023

BackgroundDespite pharmacological therapies to improve outcomes of pulmonary hypertension (PH), poor long-term survival remains. Exercised-based cardiac rehabilitation (ExCR) may be an alternative strategy to improve prognosis. Therefore, using an electronic medical record (EMR) database, the objective of this study was to compare mortality between patients with primary PH with ExCR vs. propensity-matched PH patients without ExCR.MethodsThe retrospective analysis was conducted on February 15, 2023 using anonymized data within TriNetX, a global federated health research network. All patients were aged ≥18 years with primary PH recorded in EMRs with at least 1-year follow-up from ExCR. Using logistic regression models, patients with PH with an EMR of ExCR were 1:1 propensity score-matched with PH patients without ExCR for age, sex, race, and comorbidities, and cardiovascular care.ResultsIn total, 109,736 patients with primary PH met the inclusion criteria for the control group and 784 patients with primary PH met the inclusion criteria for the ExCR cohort. Using the propensity score-matched cohorts, 1-year mortality from ExCR was proportionally lower with 13.6% (n = 101 of 744 patients) in the ExCR cohort compared to 23.3% (n = 174 of 747 patients) in the controls (OR 0.52, 95% CI 0.40–0.68).ConclusionThe present study of 1,514 patients with primary PH suggests that ExCR is associated with 48% lower odds of 1-year mortality, when compared to propensity score-matched patients without ExCR.
Multi-institutional retrospective study investigating blood culture protocols and test positivity in 701 dogs
Authors: Ogrodny Andrzej J. , Mani Rinosh , Schmid Sarah M. , Gould Emily N. , Fellman Claire L. , DeStefano Ian , Shropshire Sarah , Haines Jillian M. , Bolton Timothy A. , Jablonski Sara A. , Jess Nicole , Cridge Harry 
Published: December 2023

Objectives(i) To determine the influence of specimen collection protocol (timing and specimen quantity), primary disease process, and pre-existing antimicrobial or immunosuppressive therapy on blood culture (BC) positivity and (ii) To determine agreement between urine culture and BC results.Animals701 client-owned dogs.MethodsMulti-institutional retrospective study (2019–2022). Mixed-effect logistic regression was used to determine whether primary disease process, the number of BCs, or the timing of specimen collection was associated with BC positivity. Prediction plots were generated. Associations between urine culture and BC results were performed using logistic regression.ResultsDogs with a positive urine culture were more likely to have a positive BC (OR: 4.36, 95% CI: 2.12–8.97,p= 0.003). Dogs that had three BC specimens had the greatest odds of obtaining a positive BC result (adjusted predictive value: 0.44, 95% CI: 0.21–0.70), although this was not significant. Isolates from 38.5% of dogs with a positive BC had resistance to ≥3 antimicrobial classes. The timing between specimen collection had no significant association with BC positivity. Pre-existing antibiotic or immunosuppressive therapy had no significant association with BC positivity.Clinical relevanceDogs with a positive urine culture were more likely to have a positive BC result.
Perencanaan Sistem Penyaluran Air Limbah (SPAL) Dan Instalasi Pengolahan Air Limbah (IPAL) Domestik Terpusat Di Dukuh Desa Pendem Kecamatan Kembang Kabupaten Jepara
Authors: Qolbi Muhammad Ainun , Hidayati Nor , Rochmanto Decky , Roehman Fatchur , Faqih Nasyiin , Mushthofa Mushthofa 
Published: December 2023

Air limbah domestik di desa pendem khususnya dukuh randusari dan belik masih belum diloah dengan baik. Air limbah khususnya greywater langsung di buang diselokan yang mengarah kesungai, kegiatan tersebut dapat merusak lingkungan sungai dan mencemari sumber air bersih warga. Tujuan perencanaan ini adalah untuk merencanakan SPAL dan IPAL warga dukuh belik dan randusari agar terciptanya kondisi sanitasi lingkungan yang baik dan layak. Hasil dari perencanaan ini pada sistem penyaluran air limbah (SPAL) panjang pipa penyalur air limbah pada dukuh randusari mecapai 2.861,40 m sedangkan dukuh belik 3.028,70 m, dengan dilengkapi bangunan manhole berdiameter 60 cm dan bak kontrol 50 x 50 cm. Pada instalasi pengolahan air limbah menggunakan IPAL Biofilter Pabrikasi dengan kapasitas, pada dukuh randusari menggunakan IPAL tipe RCO-100 kapasitas 100 m3 sebanyak 3 buah dan dukuh belik digunakan IPAL tipe RCO-60 kapasitas 60 m3 sebanyak 2 buah. Dari perencanaan ini diperlukan anggaran biaya untuk pembangunan SPAL dan IPAL dukuh randusari sebesar Rp. 4.141.427.000,00. Dan untuk dukuh belik sebesar Rp. 2.586.384.000,00.
Covid-19 Pandemi Döneminde Sağlık Hizmetlerinde 4.0 Uygulamalarına İlişkin Kullanımın Çok Kriterli Karar Verme İle Değerlendirilmesi
Authors: AYDOĞAN İsa , AKBAL Hazal 
Published: December 2023

Giriş ve Amaç: İlk olarak 2019 yılında ortaya çıkan covid-19 yüksek ölümlere neden olarak sağlık başta olmak üzere eğitim, ekonomi gibi farklı ve birçok sektörü etkisi altına alması ile birlikte küresel salgın olarak ilan edilmiştir. Salgın yayılımın azaltılması amacıyla ortaya konulan sosyal izolasyon uygulamasıyla sağlık hizmetlerine erişim de kısıtlanmıştır. Bu anlamda sağlık 4.0 uygulamaları sağlık hizmetlerinin yeniden yapılanmasını sağlamıştır. Mobil uygulamalar ve çeşitli giyilebilir teknoloji ürünleri bu süreçte bireylerin sağlık hizmetlerine zaman ve yer kavramını ortadan kaldırarak erişebilmelerine imkân sağlamıştır. Bu çalışma ile covid-19 pandemi sürecinde sağlık 4.0 uygulaması kullanımının önceliklendirilmesi amaçlanmaktadır.
Gereç ve Yöntem: Bu çalışmada Çok Kriterli Karar Verme (ÇKKV) tekniklerinden olan Analitik Hiyerarşi Prosesi (AHP) kullanılmıştır. AHP, karmaşık karar problemlerini analiz etmek için karar kriterlerini hiyerarşik bir yapıda sunmaktadır. Çalışma kapsamında değerlendirilen 3 kriter ve 10 alt kriterin AHP ile karşılaştırılarak önceliklendirilmesi sağlanmıştır.
Bulgular: Pandemi döneminde kullanılan sağlık 4.0 uygulamaları içerisinde %61 oranı ile mobil uygulamalar öncelikli önem değerine sahip kriter olarak tespit edilmiştir. İkinci öncelik değerine sahip kriter %29 oranı ile tele-tıp uygulamaları olarak tespit edilirken en düşük öncelik değerine sahip uygulama giyilebilir teknolojilere ilişkin (%10) olmuştur.
Sonuç: Bu çalışma ile pandemi döneminde sağlık alanında en sık kullanılan mobil uygulamaların olduğu sonucuna varılmıştır. Kullanılan sağlık 4.0 uygulamalarının salgın döneminin devamı durumunda dijital ürün üreticileri ve pazarlayıcıları ile bu uygulamaları kullanan kişiler için çeşitli kazanımlar sağlayacağı düşünülmektedir. Bu anlamda büyük örneklem ile geniş yaş aralığını kapsayan kapsamlı bir çalışmanın yapılması daha genel bir sonuca ulaşma konusunda yardımcı olacaktır.
Effectivity of Sukamond Pudding as A Healthy Snack for Hypercholesterolemia Patients
Authors: Muzakar Muzakar , Susyani Susyani , Indah Indah , Listrianah Listrianah , Hendawati Hendawati , Ocktariyana Ocktariyana 
Published: December 2023

Background: Hypercholesterolemia is a disorder of cholesterol metabolism caused by cholesterol levels in the blood exceeding normal limits. Sukamond Pudding is a pudding made from milk flour, rice bran, and almonds, which contain high fiber, vitamin C, and Vitamin E. This study aims to analyze the effectiveness of giving Sukamond pudding as a healthy snack in hypercholesterolemia sufferers.
Method: This type of research is quantitative with a quasi-experimental research design. This research was conducted from December 2022 to January 2023 at the OKU Sekarjaya Health Center. The research sample was selected by systematic random sampling with a total sample of 60 respondents.
Result: There was an effect of giving Sukamond as a healthy snack to patients with hypercholesterolemia (p=0.000).
Conclusion: The results of statistical tests showed that there was an effect of giving Sukamond as a healthy snack to people with hypercholesterolemia.
Correlation Between Glycated Hemoglobin (Hba1c) Levels and Fasting Blood Glucose Levels in Patients with Diabetes Mellitus in Jambi City
Authors: Rahman Ranty , Amalia Fadhillah Nurul , Sakdiah Siti , S Akhirul Jumaisah 
Published: December 2023

Background: Diabetes Mellitus (DM) is a chronic disease of metabolic disorder characterized by blood sugar levels that increase from normal limits. It is necessary to prevent diabetes with control by monitoring metabolic status. The method that can be used in controlling blood sugar in patients with diabetes mellitus by measuring Hemoglobin-glycation (HbA1c). HbA1c measurement is the most accurate way to determine high blood sugar levels over the past 2 - 3 months. HbA1c is an examination to assess the risk of tissue damage caused by high sugar levels. The aimed of this study is to analyze the correlation between HbA1c levels ​​and blood sugar levels in patients with diabetes mellitus.
Method: This study used descriptive methods with an analytical descriptive study with a cross-sectional among of 100 samples, based on the criteria of respondents who checked HbA1c and fasting blood sugar. Data analysis used the Speartam correlation test which was previously carried out by the Kolmogorov-Smirnov normality test.
Result: The results of this study showed that the average HbA1c level was 3.9% while the average fasting blood sugar level was 82 mg/dl. There is a significant correlation between HbA1c concentration and fasting blood sugar with p (0.000) < (0.05). According to the test results, the value r = 0.666 means the correlation is very strong (0.51-0.75).
Conclusion: In conclusion, there is a strong correlation between HbA1c levels and fasting blood sugar level, the correlation happens to be positive, meaning there is a one-way relationship if HbA1c levels increases (High), fasting blood sugar levels will also increase (High). If the HbA1c levels is reduced (low), then the fasting blood sugar level is also reduced (low), and if the HbA1c level is normal, the blood sugar level is also normal.