bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive river flow measurement method based on spatiotemporal image velocimetry and optical flow
Authors: Wang Jianping , Chen Yingbo , Yao Guangqiang , Li Neng 
Published: February 2024

Abstract

This paper proposes an adaptive river discharge measurement method based on spatiotemporal image velocimetry (STIV) and optical flow to solve the problem of blurred texture features and limited measurement accuracy under complex natural environmental conditions. Optical flow tracking generates spatiotemporal images by following the flow mainstream direction of rivers with both regular and irregular natural banks. A texture similarity function filtering method effectively enhances spatiotemporal texture features. The proposed method is applied to a natural river, with measurement results from a propeller-type current meter used as truth values. It is evaluated and compared with three other methods regarding measurement accuracy, error, and other evaluation indices. The results demonstrate that the method significantly improves spatiotemporal image quality. Its estimation outcomes perform better across all evaluation metrics, enhancing the adaptability and accuracy of the flow measurement method.
COVID-19: Recent Insight in Genomic Feature, Pathogenesis,
Immunological Biomarkers, Treatment Options and Clinical Updates on
SARS-CoV-2
Authors: Deshmukh Rohitas , Harwansh Ranjit Kumar , Garg Akash , Mishra Sakshi , Agrawal Rutvi , Jangde Rajendra 
Published: February 2024

Abstract:
SARS-CoV-2 is a highly contagious and transmissible viral infection that first emerged
in 2019 and since then has sparked an epidemic of severe respiratory problems identified as “coronavirus disease 2019” (COVID-19) that causes a hazard to human life and safety. The virus developed mainly from bats. The current epidemic has presented a significant warning to life across the
world by showing mutation. There are different tests available for testing Coronavirus, and RTPCR is the best, giving more accurate results, but it is also time-consuming. There are different options available for treating n-CoV-19, which include medications such as Remdesivir, corticosteroids, plasma therapy, Dexamethasone therapy, etc. The development of vaccines such as BNT126b2, ChAdOX1, mRNA-1273 and BBIBP-CorV has provided great relief in dealing with the
virus as they decreased the mortality rate. BNT126b2 and ChAdOX1 are two n-CoV vaccines
found to be most effective in controlling the spread of infection. In the future, nanotechnology-based vaccines and immune engineering techniques can be helpful for further research on Coronavirus and treatment of this deadly virus. The existing knowledge about the existence of SARS--
CoV-2, along with its variants, is summarized in this review. This review, based on recently published findings, presents the core genetics of COVID-19, including heritable characteristics, pathogenesis, immunological biomarkers, treatment options and clinical updates on the virus, along
with patents.
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention
and Treatment of Diseases: A Review
Authors: Bhardwaj Kanchan , Bhargav Rashi , Patocka Jiri , Sharma Ruchi , Navratilova Zdenka , Oleksak Patrik , Kuca Kamil 
Published: February 2024

Abstract:
A sesquiterpenic alkaloid dendrobine is the major bioactive compound extracted from
Dendrobium nobile Lindl. This compound was structurally very similar to picrotoxinin (neurotoxin)
containing bicyclic or tricyclic ring while dendrobine containing tetracyclic rings with up to 7 stereogenic
centers showing numerous neuroprotective effects. Several sesquiterpenic alkaloids such as
(+)-(1R,5R,6S,8R,9R)- 8,12-dihydroxy-copacamphan-3-en-2-one, dendrobine, denrine B, (+)-
(1R,2S,3R,4S,5R,6S,9R)-3,11,12-trihydroxypicrotoxane-2(15)-lactone, dendroxine B, nobilonine,
13-Hydroxy-14-oxodendrobine, 6-Hydroxy-nobilonine and (−)-(1S,2R,3S,4R,5S,6R,9S,12R)-
3,11,13-trihydroxypicrotoxane-2(15)-lactone were isolated from D. nobile This comprehensive review
summarizes the necessary information on the morphology, biochemistry and pharmacology of
dendrobine. The phytochemical profile had potent in-vivo and in-vitro efficacy in neuroprotection,
nerve function, memory enhancement, cognitive disorders, anxiety and depression, anti-oxidant,
psychological conditions, increasing serotonin concentration in synapse anxiolytic, tranquilizing,
anti-stress, neurodegenerative (Alzheimer’s disease and Parkinson), anti-inflammatory and analgesic.
The compound dendrobine activates neuro synapses, serotonergic synapse and signaling pathways
during neurotransmission playing important role in Alzheimer’s disease, Parkinson's disease,
anxiety and long-term depression.
Dissecting the Mechanisms of Intestinal Immune Homeostasis by
Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal
Cancer
Authors: Jiang Tianming , Zheng Jie , Li Nana , Li Xiaodong , He Jixing , Zhou Junde , Sun Boshi , Chi Qiang 
Published: February 2024

Introduction:
Crohn's disease (CD) and colorectal cancer (CRC) represent a group of
intestinal disorders characterized by intricate pathogenic mechanisms linked to the disruption of intestinal
immune homeostasis. Therefore, comprehending the immune response mechanisms in
both categories of intestinal disorders is of paramount significance in the prevention and treatment
of these debilitating intestinal ailments.

Method:
In this study, we conducted single-cell analysis on paired samples obtained from primary
colorectal tumors and individuals with Crohn's disease, which was aimed at deciphering the
factors influencing the composition of the intestinal immune microenvironment. By aligning T
cells across different tissues, we identified various T cell subtypes, such as γδ T cell, NK T cell,
and regulatory T (Treg) cell, which maintained immune system homeostasis and were confirmed
in enrichment analyses. Subsequently, we generated pseudo-time trajectories for subclusters of T
cells in both syndromes to delineate their differentiation patterns and identify key driver genes.

Result:
Furthermore, cellular communication and transcription factor regulatory networks are all
essential components of the intricate web of mechanisms that regulate intestinal immune homeostasis.
The identified complex cellular interaction suggested potential T-lineage immunotherapeutic
targets against epithelial cells with high copy number variation (CNV) levels in CD and CRC.

Conclusion:
Finally, the analysis of regulon networks revealed several promising candidates for
cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism
under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape
and revealing T-cell responding mechanisms in CD and CRC.
Risk Factors for Cerebral Hyperperfusion Syndrome After Combined Revascularization in Adult Patients with Moyamoya Disease
Authors: Xu Dongxiao , Guo Jiaojiao , Zheng Bingjie , Wu Qiaowei , Gareev Ilgiz , Beylerli Ozal , Beilerli Aferin , Shi Huaizhang 
Published: February 2024

Background:
Cerebral hyperperfusion syndrome (CHS) is known as a complication
after bypass surgery for Moyamoya disease (MMD). However, the incidence of CHS has not
been accurately reported, and there is no consensus on the risk factors associated with it.

Aim:
The aim of this study was to determine the risk factors associated with postoperative CHS
after surgical combined revascularization used to treat adult patients with MMD.

Objective:
To assess the frequency and characteristics of CHS in patients with MMD after revascularization
operations.

Methods:
Patients who received combined revascularization from Jan 2021 to Nov 2022 were
retrospectively reviewed. Preoperative clinical characteristics and radiographic features were
recorded. Postoperative CHS after surgery were examined. Multivariate logistic regression analyses
were performed to identify the risk factors for CHS.

Results:
A total of 133 patients (141 hemispheres) were included in this study. Postoperative
CHS were observed in 28 hemispheres (19.8%), including focal cerebral hyperperfusion syndrome
(FCHS) in 20 hemispheres (14.2%), hemorrhage in 4 (2.8%) hemispheres, seizures in 4
(2.8%) hemispheres. The results of multivariate logistic regression analysis indicated that preoperative
hypertension (OR 4.705, 95% CI 1.323 ~ 12.554, p = 0.014), cerebral hemorrhage onset
(OR 5.390, 95% CI 1.408 ~ 20.642, p = 0.014) and higher Hct level (OR 1.171, 95% CI 1.051 ~
1.305, p = 0.004) were significantly associated with CHS after combined revascularizatio

Conclusions:
Preoperative hypertension, cerebral hemorrhage onset, and higher Hct level were
independent risk factors for CHS after combined revascularization.
Quantitative Perfusion Analysis of Contrast-enhanced Ultrasound Might Help
Differentiate Benign and Malignant Solid Cystic Lesions of the Kidney: A Case
Report and Literature Review
Authors: Ying Li , Luo Li , Li Fang , Zhou Hang , Tao Xueshuang , Ling Yun 
Published: February 2024

Background::
Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare benign lesion that appears as a solid cystic renal lesion or complex renal
cystic lesion on medical imaging. There are no definite imaging criteria for METSK diagnosis.

Case Presentation::
We present a case of a solid cystic renal mass that was evaluated by contrast-enhanced ultrasound (CEUS) during an imaging workup. The patient
underwent nephrectomy and histopathological confirmation of MESTK. The lesions showed hypoenhancement during the process. Quantitative
perfusion analysis showed the septation of the solid cystic lesion to have lower peak enhancement with a longer rise time compared to the normal
renal cortex.

Discussion::
CEUS can visualize the microcirculation of the organ and reconstruction of the vessels. By providing a more detailed visualization of the
microvessel, CEUS is a useful tool for further characterizing renal lesions that show indeterminate enhancement on CT. This study determined the
time to peak to be shorter for the cancerous lesion than the normal renal cortex, while peak intensity did not differ between the cancerous lesion
and the normal renal cortex.

Conclusion::
Quantitative perfusion analysis of CEUS may be useful for differentiating benign and malignant solid cystic renal masses. Further investigation is
needed to determine whether peak intensity is a useful parameter in differentiating benign and malignant solid cystic lesions of the kidney.
nnUNet for Automatic Kidney and Cyst Segmentation in Autosomal Dominant
Polycystic Kidney Disease
Authors: Krishnan Chetana , Schmidt Emma , Onuoha Ezinwanne , Mrug Michal , Cardenas Carlos E. , Kim Harrison 
Published: February 2024

Background::
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder that causes uncontrolled kidney cyst growth, leading to kidney
volume enlargement and renal function loss over time. Total kidney volume (TKV) and cyst burdens have been used as prognostic imaging
biomarkers for ADPKD.

Objective::
This study aimed to evaluate nnUNet for automatic kidney and cyst segmentation in T2-weighted (T2W) MRI images of ADPKD patients.

Methods::
756 kidney images were retrieved from 95 patients in the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)
cohort (95 patients × 2 kidneys × 4 follow-up scans). The nnUNet model was trained, validated, and tested on 604, 76, and 76 images, respectively.
In contrast, all images of each patient were exclusively assigned to either the training, validation, or test sets to minimize evaluation bias. The
kidney and cyst regions defined using a semi-automatic method were employed as ground truth. The model performance was assessed using the
Dice Similarity Coefficient (DSC), the intersection over union (IoU) score, and the Hausdorff distance (HD).

Results::
The test DSC values were 0.96±0.01 (mean±SD) and 0.90±0.05 for kidney and cysts, respectively. Similarly, the IoU scores were 0.91± 0.09 and
0.81±0.06, and the HD values were 12.49±8.71 mm and 12.04±10.41 mm, respectively, for kidney and cyst segmentation.

Conclusion::
The nnUNet model is a reliable tool to automatically determine kidney and cyst volumes in T2W MRI images for ADPKD prognosis and therapy
monitoring.
Research Progress in the Detection of Aflatoxin B1 Based on Aptamers
Authors: Zhang Yi , Chen Xiaofang , Xie Xiaoyi , Li Dong , Fan Yuxiu , Huang Bin , Yang Xiupei 
Published: February 2024

Abstract:
Aflatoxin B1 is highly toxic, mutagenic, teratogenic, and carcinogenic and is a class I
carcinogen. Peanuts, cotton, and corn may be affected by AFB1 during cultivation, which can seriously
jeopardize human health. Developing a simple, sensitive, and selective method for detecting
AFB1 is imminent. Aptamers are obtained through in vitro screening of ligands by single-stranded
oligonucleotides (DNA or RNA) through exponential enrichment (SELEX) technology. As emerging
highly selective recognition molecules, they have the advantages of strong affinity, good stability,
and strong specificity. Because it does not have the function of signal conversion, it cannot produce
physicochemical signals that can be detected in the process of specific binding with target molecules,
so it is necessary to convert the process of specific binding of aptamers to target molecules into a
process of easily detectable physicochemical signal changes. According to different conversion
methods, aptamer biosensors are divided into electrochemical aptamer sensors, fluorescent aptamer
sensors, colorimetric aptamer sensors, surface Raman-enhanced aptamer sensors, and so on. Herein,
the recent progress and application of aflatoxin B1 detection by nucleic acid aptamer biosensors
based on the above signals are reviewed, and the future development prospects and challenges of this
kind of biosensor are summarized.
Impact of Nicosulfuron on Sperm Quality: Insights into Testicular Cell
Apoptosis and NF-κB Signaling Pathway in Mice Testes
Authors: Han Jianqiu , Zhao Chen , Shen Qing , Qi Yalei , Zhang Yanjia , Raza Faisal , Li Yongmei , Zafar Hajra , Liu Tengfei , Tan Juan , Han Honghui , Ma Xueyun 
Published: February 2024

Background::
Nicosulfuron, a widely used herbicide in crops, has raised concerns due to its escalating presence as an environmental pollutant, particularly in soil
and water. The potential adverse effects of nicosulfuron on animals, including reproductive toxicity, have garnered attention.

Objective::
The study aimed to evaluate the reproductive toxicity of nicosulfuron in male mice.

Methods::
Male mice were orally administrated with three different concentration gradients (350, 700, and 1400 mg/kg) of nicosulfuron for 35 days. The
investigation delved into sperm quality, testicular structures, and expression of cleaved caspase-3 and NF-κB p65 of the testes.

Results::
The finding unveiled a correlation between nicosulfuron exposure and detrimental effects on sperm quality and alteration of testicular structure.
Notably, parameters, such as sperm survival rate (SUR) and sperm motility (MOT), exhibited a decline in relation to increasing nicosulfuron
dosages. Moreover, in the mice subjected to higher doses of nicosulfuron, elevated expression of cleaved caspase-3 and NF-κB p65 was observed
in the testes. Interestingly, we also observed an increase of NF-κB p65 expression in the mice exposed to the nicosulfuron.

Conclusion::
Our research revealed that exposure to nicosulfuron resulted in compromised sperm quality and alterations in testicular structure. The correlation
between nicosulfuron and apoptosis, especially via the NF-κB pathway, provided significant insights into the mechanisms underpinning these
detrimental effects. These findings significantly enhance our comprehension of the potential hazards associated with nicosulfuron exposure and its
impacts on the reproductive health of animals.
Multiple Perspectives on the Adoption of SMART Technologies for Improving Care of Older People: Mixed Methods Study
Authors: Elavsky Steriani , Knapova Lenka , Janiš Kamil , Cimler Richard , Kuhnova Jitka , Cernicky Tomas 
Published: February 2024

Background
Despite the ever-increasing offering of SMART technologies (ie, computer-controlled devices acting intelligently and capable of monitoring, analyzing or reporting), a wide gap exists between the development of new technological innovations and their adoption in everyday care for older adults.

Objective
This study aims to explore the barriers and concerns related to the adoption of SMART technologies among different groups of stakeholders.

Methods
Data from 4 sources were used: semistructured in-person or internet-based interviews with professional caregivers (n=12), structured email interviews with experts in the area of aging (n=9), a web-based survey of older adults (>55 years) attending the Virtual University of the Third Age (n=369), and a case study on the adoption of new technology by an older adult care facility.

Results
Although all stakeholders noted the potential of SMART technologies to improve older adult care, multiple barriers to their adoption were identified. Caregivers perceived older adults as disinterested or incompetent in using technology, reported preferring known strategies over new technologies, and noted own fears of using technology. Experts viewed technologies as essential but expressed concerns about cost, low digital competency of older adults, and lack of support or willingness to implement technologies in older adult care. Older adults reported few concerns overall, but among the mentioned concerns were lack of ability or interest, misuse of data, and limited usefulness (in specific subgroups or situations). In addition, older adults’ ratings of the usefulness of different technologies correlated with their self-rating of digital competency (r=0.258; P<.001).

Conclusions
Older adults appeared to have more positive views of various technologies than professional caregivers; however, their concerns varied by the type of technology. Lack of competence and lack of support were among the common themes, suggesting that educationally oriented programs for both older adults and their caregivers should be pursued.
A Web-Based Peer-Patient Navigation Program (Compassionate Online Navigation to Enhance Care Transitions) for Youth Living With Childhood-Acquired Disabilities Transitioning From Pediatric to Adult Care: Qualitative Descriptive Study
Authors: Kokorelias Kristina Marie , Lee Tin-Suet Joan , Bayley Mark , Seto Emily , Toulany Alene , Nelson Michelle L A , Dimitropoulos Gina , Penner Melanie , Simpson Robert , Munce Sarah E P 
Published: February 2024

Background
Studies have highlighted significant challenges associated with the transition from pediatric to adult health and social care services for youth living with childhood-acquired disabilities and their caregivers. Patient navigation has been proposed as an effective transitional care intervention. Better understanding of how patient navigation may support youth and their families during pediatric to adult care transitions is warranted.

Objective
This study aims to describe the preferred adaptations of an existing web-based platform from the perspectives of youth with childhood-onset disabilities and their family caregivers to develop a web-based peer-patient navigation program, Compassionate Online Navigation to Enhance Care Transitions (CONNECT).

Methods
A qualitative descriptive design was used. Participants included youth living with childhood-acquired disabilities (16/23, 70%) and their caregivers (7/23, 30%). Semistructured interviews and focus groups were conducted, digitally recorded, and transcribed. Thematic analysis was used to analyze the data and was facilitated through NVivo software (Lumivero).

Results
Participants desired a program that incorporated (1) self-directed learning, (2) a library of reliable health and community resources, and (3) emotional and social supports. On the basis of participants’ feedback, CONNECT was deemed satisfactory, as it was believed that the program would help support appropriate transition care through the provision of trusted health-related information. Participants highlighted the need for options to optimize confidentiality in their health and social care and the choice to remain anonymous to other participants.

Conclusions
Web-based patient navigation programs such as CONNECT may deliver peer support that can improve the quality and experience of care for youth, and their caregivers, transitioning from pediatric to adult care through personalized support, health care monitoring, and health and social care resources. Future studies are needed to test the feasibility, acceptability, usability, use, and effectiveness of CONNECT among youth with childhood-onset disabilities.
Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study
Authors: Liu Chenan , Zhang Qingsong , Liu Chenning , Liu Tong , Song Mengmeng , Zhang Qi , Xie Hailun , Lin Shiqi , Ren Jiangshan , Chen Yue , Zheng Xin , Shi Jinyu , Deng Li , Shi Hanping , Wu Shouling 
Published: February 2024

Background
Baseline sleep duration is associated with cancer risk and cancer-specific mortality; however, the association between longitudinal patterns of sleep duration and these risks remains unknown.

Objective
This study aimed to elucidate the association between sleep duration trajectory and cancer risk and cancer-specific mortality.

Methods
The participants recruited in this study were from the Kailuan cohort, with all participants aged between 18 and 98 years and without cancer at baseline. The sleep duration of participants was continuously recorded in 2006, 2008, and 2010. Latent mixture modeling was used to identify shared sleep duration trajectories. Furthermore, the Cox proportional risk model was used to examine the association of sleep duration trajectory with cancer risk and cancer-specific mortality.

Results
A total of 53,273 participants were included in the present study, of whom 40,909 (76.79%) were men and 12,364 (23.21%) were women. The average age of the participants was 49.03 (SD 11.76) years. During a median follow-up of 10.99 (IQR 10.27-11.15) years, 2705 participants developed cancers. Three sleep duration trajectories were identified: normal-stable (44,844/53,273, 84.18%), median-stable (5877/53,273, 11.03%), and decreasing low-stable (2552/53,273, 4.79%). Compared with the normal-stable group, the decreasing low-stable group had increased cancer risk (hazard ratio [HR] 1.39, 95% CI 1.16-1.65) and cancer-specific mortality (HR 1.54, 95% CI 1.18-2.06). Dividing the participants by an age cutoff of 45 years revealed an increase in cancer risk (HR 1.88, 95% CI 1.30-2.71) and cancer-specific mortality (HR 2.52, 95% CI 1.22-5.19) only in participants younger than 45 years, rather than middle-aged or older participants. Joint analysis revealed that compared with participants who had a stable sleep duration within the normal range and did not snore, those with a shortened sleep duration and snoring had the highest cancer risk (HR 2.62, 95% CI 1.46-4.70).

Conclusions
Sleep duration trajectories and quality are closely associated with cancer risk and cancer-specific mortality. However, these associations differ with age and are more pronounced in individuals aged <45 years.

Trial Registration
Chinese Clinical Trial Registry ChiCTR–TNRC–11001489; http://tinyurl.com/2u89hrhx