bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad‐Scale Meta‐Analysis of Drivers Mediating Adverse Impacts of Flow Regulation on Riparian Vegetation
Authors: Su Xiaolei , Bejarano María Dolores , Jansson Roland , Pilotto Francesca , Sarneel Judith M. , Lin Feng , Wang Yi , Cai Fu , Wu Shan , Zeng Bo 
Published: February 2025

ABSTRACTOver two‐thirds of global rivers are subjected to flow regulation. Although it is widely recognized that flow regulation can adversely affect riparian vegetation—a critical component of river ecosystems—the specific roles of various drivers remain poorly understood. To address this gap, we conducted a broad‐scale meta‐analysis, aiming to elucidate how different factors mediate the adverse impacts of flow regulation on riparian vegetation. This meta‐analysis encompassed 59 papers, spanning 278 dams constructed on 146 rivers. We extracted data on four key indices of riparian vegetation: species richness and abundance of all riparian species, and those indices exclusively for non‐native species. Indices were compared between regulated and free‐flowing or pre‐damming rivers to quantify the impact of flow regulation. Our meta‐analysis revealed a moderate but significant reduction in the richness and abundance of all riparian species under flow regulation, coupled with a strong increase in the abundance of non‐native species. Riparian vegetation in arid and continental climate regions experienced stronger negative impacts than those in tropical and temperate climates. Furthermore, the adverse effects on riparian vegetation were more pronounced downstream of dams than upstream. Considering climate region, study identity, and relative position to the dam as random variables, it became evident that years since flow regulation emerged as the most important factor influencing species richness. Over time, richness gradually recovered from initially low levels. However, this recovery was slowed by increasing flow regulation intensity (percentage of annual runoff stored). Additionally, the impact was more evident in larger rivers. To support regulated river management, we recommend prioritizing the protection of riparian vegetation in arid and continental climates, with emphasis on areas downstream of dams, limiting flow regulation intensity, particularly in larger rivers, and monitoring non‐native species to prevent disproportionate spread.
How different emotions emerge in the context of the energy crisis: A contribution to emotional energy geographies
Authors: Budnik Maria , Grossmann Katrin , Hess Celine , Wemheuer Tine 
Published: February 2025

AbstractThe emerging field of emotional energy geography within energy social sciences explores the intersection of energy systems and lived experiences. Pioneering contributions emphasise the need to understand energy usage and decision‐making in novel ways. This paper contributes to this discourse by examining emotions in the face of insecurity, steep price increases, and a political crisis, focusing on Germany during the 2022 European energy crises. Political actors predicted either a ‘hot autumn’ or a ‘winter of rage’. However, the massive protests that were anticipated scarcely materialised, and the groups affected internalised the crisis. The study investigates how individuals felt about the situation when rage did not manifest on the streets, exploring the emergence of other emotions. It explores emotions such as fear of costs, conflicts over energy provision, social stress, and pride in energy‐saving capacities. The literature on social psychology and emotional sociology posits that emotions arise through the process of defining a given situation. Here, attribution of responsibility appears crucial for the understanding of varied emotional reactions. Shame may lead to internalised conflict avoidance, while collective anger becomes a mobilising force. Drawing on four expert interviews and 30 qualitative interviews with retirees, single parents, and students—groups vulnerable to rising energy costs—the paper challenges expectations of widespread anger. Instead, emotional experiences are intricately tied to existing strategies for coping with poverty and support networks that mitigate the impact of the crises. The findings contribute to a better empirical understanding of emotions in social crises, highlighting the roles of pre‐existing coping mechanisms and support structures in shaping emotional responses.
Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC
Authors: Wen You‐Lu , Guo Fang , Gu Ting‐ting , Zeng Yan‐ping , Cao Xiong 
Published: February 2025

ABSTRACTAstrocytes, the most prevalent type of glial cells, have been found to play a crucial part in numerous physiological functions. By offering metabolic and structural support, astrocytes are vital for the proper functioning of the brain and regulating information processing and synaptic transmission. Astrocytes located in the medial prefrontal cortex (mPFC) are highly responsive to environmental changes and have been associated with the development of brain disorders. One of the primary mechanisms through which the brain responds to environmental factors is epitranscriptome modification. M6‐methyladenosine methylation is the most prevalent internal modification of eukaryotic messenger RNA (mRNA), and it significantly impacts transcript processing and protein synthesis. However, the effects of m6A on astrocyte transcription and function are still not well understood. Our research demonstrates that ALKBH5, an RNA demethylase of m6A found in astrocytes, affects gene expression in the mPFC. These findings suggest that further investigation into the potential role of astrocyte‐mediated m6A methylation in the mPFC is warranted.
The World Café as a Tool for Evaluating the Level of Acceptance of SARS‐CoV‐2 Screening in School Settings, Puglia Region, Italy, 2023
Authors: Gabellone Valeria , Nuccetelli Fabiana , Gabrielli Elisa , Ascatigno Leonardo , Lopalco Pier Luigi , Prato Rosa 
Published: February 2025

ABSTRACTBackgroundThe introduction of screening tests for Sars‐CoV‐2 has been an extraordinary prevention and control tool during the COVID‐19 pandemic. However, pandemic control interventions, including screening and vaccine mandates, induced refusal reactions in many people. To date, little information is available on the levels of acceptance of screening practices by the young population in school settings.ObjectiveThe objective of this work is to survey students' attitudes, behaviours and emotions towards Covid‐19 screening tests by the means of a participatory research method, the World Café (WC).Materials and MethodsBetween March and May 2023, three WC sessions were conducted in three high schools, with 70 students enrolled on a voluntary basis. As per standard procedure, a moderator was assigned at each table to facilitate dialogue and the WCs were recorded, transcribed and imported into ATLAS.ti software for qualitative analysis.ResultsThe analysis showed that the themes most reported during the WCs were those regarding the emotional domain, particularly feelings of distress, anxiety, fear, frustration, inadequacy and loneliness.DiscussionAlthough the themes ‘Emotions/thoughts’ appear to be the most prominent among students, also ‘Public health policies’ constitutes a predominant theme group. Finally, the theme ‘Communication’ sparked lively debate, being the fourth most discussed topic.ConclusionsThe many insights from the WC analysis, when properly reframed, bring out useful elements for taking actions during prevention campaigns. Institutions and schools should focus on disseminating clear and targeted messages to help fight misinformation and distrust. Moreover, such evidence suggests that the World Café method proves to be useful and effective for exploring the emotional sphere of adolescents and analysing their thoughts, attitudes and knowledge.Patient or Public ContributionThe research team collaborated with the school personnel to set up the right setting for running the World Café sessions. The World Café method allowed the researchers to gather students' insights by the means of a participative process. Honest debate and active engagement of students provided the researchers with a list of statements very useful for informing health policy and recommendations.
Setting Primary Health and Social Care Priorities Using a Deliberative Democratic Participatory Approach
Authors: Wales Coralie , Abbott Penny , Street Jackie , Fawcett Lauren , Jennings Maree , Sharp Wendy , Lee Philip 
Published: February 2025

AbstractIntroductionPublicly funded regional primary health care investments are usually informed by analysis of locally collected data, surveys, focus groups and consultations. We wanted a deeper understanding of baseline health and social care priorities in culturally diverse Western Sydney. If WentWest could understand the priorities, the operational agenda for commissioning services could be tailored around them. This research describes the organisation, conduct and recommendations of a citizens' jury in 2023.MethodsThematic analysis of the transcribed facilitated discussions identified the well‐informed priorities of a diverse and representative group of Western Sydney citizens. Listening to internal and external advisory groups delivered communication pathways, expert presenters, handbook preparation and practical support for the jury event. Consistent with the principle that research about the community should include the community, four consumer advisors were colleagues in the research team.ResultsThe jury supported a focus on prevention, including early intervention to keep children thriving and connected at school, and better cross‐sectoral bonds via coalitions to enable social care to be linked to health care. Team‐based care in general practice for proactive data use and building a culture for relationship‐based care, developing a patient‐centred workforce through incentivising students and expediting registration of overseas trained health workers were recommended. Assets‐based community development was seen as an essential approach in linking the community with these recommendations.ConclusionThe use of citizens' juries in primary health settings is rare. In this culturally diverse community, WentWest now has a foundational understanding of what investments will deliver and has committed to institutionalising this deliberative approach into a permanent citizens assembly.Patient and Public ContributionThe design of the jury was guided by several advisory groups across the local region. The research team included four consumer advisors to provide overarching feedback and external insights. The jurors were selected to be representative of the regional community. They developed the recommendations reported in this article.Trial RegistrationThis research does not involve clinical trials.
Morality as a cause, not only an effect, of evolution: Thomistic reflections on gene‐culture coevolutionary theory
Authors: Lyons Nathan 
Published: February 2025

AbstractSome recent philosophical analyses of gene‐culture coevolutionary theory propose that morality is a contributing cause in (and not only an outcome of) human evolution. This paper considers implications of this idea for Thomistic moral theory. According to the coevolutionary account, the social practices of early human communities create selection pressures in favour of pro‐moral adaptations, making the evolution of morality a ‘biocultural’ process in which culture in some respects drives biology. This position chimes with, and indeed advances, some core themes of Thomistic ethics, including: the abiding significance of moral passions; the centrality of practical reason; the social character of practical reason; moral realism; the naturalness of morality; the link between nature and normativity. Biocultural evolutionary theory can thus offer Thomistic ethicists some new ways to understand their old ideas. If it is true that morality is a cause and not only an effect of human evolution, then Thomists are invited to see morality as an even more natural phenomenon than they previously thought.
Stage III substaging and outcomes in patients with bladder cancer undergoing radical cystectomy
Authors: Hara Shuhei , Fukuokaya Wataru , Miki Jun , Taoka Rikiya , Saito Ryoichi , Matsui Yoshiyuki , Hatakeyama Shingo , Kawahara Takashi , Matsuda Ayumu , Kawai Taketo , Kato Minoru , Sazuka Tomokazu , Sano Takeshi , Urabe Fumihiko , Kashima Soki , Naito Hirohito , Murakami Yoji , Miyake Makito , Daizumoto Kei , Matsushita Yuto , Hayashi Takuji , Inokuchi Junichi , Sugino Yusuke , Shiga Kenichiro , Yamaguchi Noriya , Yamamoto Shingo , Yasue Keiji , Abe Takashige , Nakanishi Shotaro , Hashine Katsuyoshi , Fujii Masato , Nishihara Kiyoaki , Matsumoto Hiroaki , Tatarano Shuichi , Wada Koichiro , Sekito Sho , Maruyama Ryo , Nishiyama Naotaka , Nishiyama Hiroyuki , Kitamura Hiroshi , Kimura Takahiro ,   the Japan Urological Oncology Group
Published: February 2025

ObjectiveTo examine the association between substaging and outcomes following radical cystectomy (RC) in patients with stage III bladder cancer.MethodsWe conducted a retrospective observational study using nationwide data from Japan, including 708 patients with stage III bladder cancer who underwent RC. Substaging was based on the American Joint Committee on Cancer's 8th edition. pT3‐4aN0 and pTanyN1 were newly defined as stage IIIA, while pTanyN2‐3 were defined as stage IIIB. Baseline covariates were balanced using inverse probability of treatment weighting. We analyzed disease‐free survival (DFS) and overall survival (OS) across these substages and among the sub‐groups: pT3‐4aN0, pTanyN1, and pTanyN2‐3.ResultsWe found evidence that stage IIIB bladder cancer had inferior outcomes than stage IIIA (DFS, hazard ratio, 1.61 [95% confidence interval, 1.28–2.02]; OS, 1.61 [1.25–2.09]). Furthermore, there was evidence of the difference in outcomes between pT3‐4aN0 versus pTanyN2‐3 (DFS, 1.73 [1.35–2.23]; OS, 1.63 [1.23–2.15]), while no evidence of the difference between pT3‐4aN0 and pTanyN1 was observed (DFS, 1.27 [0.96–1.67]; OS, 1.09 [0.78–1.53]). We did not find evidence of heterogeneity in the effects of the substaging on OS by the use of perioperative chemotherapy.ConclusionThis prognostic study supports the current stage III substaging of patients with bladder cancer who underwent RC. Importantly, there was no difference in OS between pT3‐4N0 and pTanyN1 in patients with stage IIIA bladder cancer. These findings may help guide treatment decisions for patients with stage III operable bladder cancer.
Nanoindentation and deformation behaviors of α$\alpha$‐Al2O3${\rm Al}_2 {\rm O}_3$: A molecular dynamic study
Authors: Xu Qinqin , Goda Ibrahim , Zhang Yanming , Papanikolaou Stefanos 
Published: February 2025

AbstractStudying the nanoindentation behavior of materials at the atomic level is crucial for advancing technologies involving energetic atom bombardment, ion implantation, and nanomechanical testing. Using molecular dynamics simulations with two typical rigid ion interatomic potentials (fixed charges), we showed that the mechanical responses and dislocation nucleation of alumina (‐) are highly temperature‐ and orientation‐dependent. The complex behavior in dislocation dynamics has been rationalized by computing the distribution of stacking fault energy. It is further found that SHIK potential provides better accuracy in describing dislocation dynamics at a much lower computational cost.
Optimizing the mechanical performance of nacre‐like hydroxyapatite/polymethylmethacrylate–polyacrylic acid composites with apatite‐wollastonite
Authors: Tabrizian Parinaz , Sun Huijun , Ghorbani Farnaz , Qambrani Aqsa , Armstrong James P. K. , Sui Tan , Davis Sean , Su Bo 
Published: February 2025

AbstractBiomimetic materials inspired by the hierarchical structure of nacre offer promising opportunities to enhance the mechanical strength and toughness of load‐bearing bone implants. This study investigates the incorporation of apatite‐wollastonite (AW) into nacre‐like hydroxyapatite (HA)/polymethylmethacrylate–polyacrylic acid (PMMA–PAA) composites to improve their mechanical properties. The composite mimics the natural nacre structure, featuring a brick‐and‐mortar architecture where ceramic components form the “bricks,” and the polymer phase acts as the “mortar.” The results showed that adding AW significantly increased the density of the ceramic scaffolds and improved the sinterability of HA. However, at higher AW concentrations (e.g., 20 wt%), excessive grain growth was observed, which could negatively affect the composite's mechanical properties. The best mechanical performance was achieved at 15 wt% AW, which enhanced the sintering process and reinforced the HA through the formation of a stronger wollastonite phase, as revealed by x‐ray diffraction analysis. Mechanical testing showed that the composite with 15 wt% AW exhibited superior properties, with flexural strength increasing from 158.2 ± 7.1 MPa (for HA/PMMA–PAA) to 188.7 ± 6.2 MPa (for AW–HA/PMMA–PAA). Fracture toughness also improved significantly, from 5.2 to 10.2 MPa m1/2. In addition to improved flexural strength and fracture toughness, the composite's Young's modulus of 28.5 ± 1.6 GPa closely matched that of cortical bone, reducing the risk of stress shielding, a common issue with commercial implants. Acellular bioactivity tests demonstrated the formation of a biologically relevant apatite layer on the composite surface, indicating its potential to promote osseointegration. Cytocompatibility assays confirmed favorable cell proliferation and viability, supporting its suitability for clinical applications. In summary, the addition of AW enhanced sinterability and introduced a stronger wollastonite phase within the HA ceramic layer, leading to improved strength and toughness of the nacre‐like HA/PMMA–PAA composites. However, there was an optimal AW concentration that balanced superior mechanical properties with controlled grain growth. The bioactive and cytocompatible composites showed great promise as candidates for next‐generation load‐bearing bone implants.
Coupled Ultrasound and Microwave‐Assisted Extraction of Carotenoids From Citrus clementina Peels and In Vitro Evaluation of Their Biological Activities
Authors: Kadi Ahcene , Teffane Mohand , Taibi Abdeslem , Arroul Younes , Boudries Hafid , Bachir‐bey Mostapha , Souagui Samiha 
Published: February 2025

ABSTRACTThis research investigates the optimization of carotenoid extraction from Citrus clementina peels using Ultrasonic‐Microwave‐assisted extraction (U‐MAE) and evaluates their biological activities. The study employs Response surface methodology (RSM) to determine optimal extraction parameters (hexane percentage in hexane/acetone mixture, sonication time, and irradiation time) that yielded the highest total carotenoid content (TCC) with high total antioxidant activity (TAA) and to assess the impact of each parameter on the responses. Additionally, the antioxidant capacity, anti‐inflammatory, antidiabetic, and antimicrobial activities were analyzed using in vitro spectrophotometric methods. The results demonstrate a significant positive correlation between hexane percentage and both TCC and TAA. Furthermore, the results revealed that shorter sonication and irradiation times led to important increases in TCC and TAA. Additionally, the study assessed the effect of particle size on TCC and TAA, showing that finer particle sizes resulted in higher carotenoid content and antioxidant activity. The carotenoid‐rich extract exhibited robust antioxidant, anti‐inflammatory, and antidiabetic activities, as well as notable antibacterial and antifungal properties, suggesting its potential application as a substitute for synthetic counterparts in various industries, including food and pharmaceuticals. Overall, this research provides valuable insights into the extraction and bioactivity of carotenoids from C. clementina peels.
Assessment of intra‐amniotic colonization based on copy numbers of 16S ribosomal deoxyribonucleic acid: A diagnostic and prognostic study
Authors: Urushiyama Daichi , Kiyoshima Chihiro , Hirakawa Toyofumi , Shibata Mami , Imi Shiori , Kurakazu Masamitsu , Miyata Kohei , Setoue Takashi , Nagamitsu Shinichiro , Nomiyama Makoto , Nakabayashi Kazuhiko , Yotsumoto Fusanori , Hata Kenichiro , Miyamoto Shingo 
Published: February 2025

AbstractAimThis study aimed to assess amniotic fluid bacterial load using the copy number of 16S ribosomal deoxyribonucleic acid and to clarify its association with perinatal outcomes.MethodsThis retrospective diagnostic and prognostic study included 63 patients with preterm labor and suspected intra‐amniotic infection who underwent amniocentesis before 34 weeks of gestation. We measured the copy number of 16S ribosomal deoxyribonucleic acid in 1 mL of amniotic fluid using droplet digital polymerase chain reaction and graded infections as Grade (G) 0, 1, 2, or 3. Case–control analysis was performed to compare G3 (N = 29), G1–2 (N = 18), and G0 (N = 17) patients. The main outcome measures were histologic chorioamnionitis, funisitis, and amniocentesis‐to‐delivery time windows.ResultsThe frequency of histologic chorioamnionitis (Stage III) and funisitis was as follows: G3, 86% and 79%; G1–2, 28% and 56%; and G0, 0% and 6%, respectively. The rate of post‐amniocentesis delivery within 1 and 2 days was as follows: G3, 62% and 83%; G1–2, 56% and 78%; G0, 13% and 25%, respectively. Comparisons between the G3 and G0 groups revealed significant differences in all criteria (p < 0.05). Additionally, significant differences were noted in pathological inflammatory findings between the G3 and G1–2 groups, as well as in all perinatal outcomes between the G1–2 and G0 groups (p < 0.05).ConclusionsOur diagnostic method, based on the copy number of 16S ribosomal deoxyribonucleic acid, supports intra‐amniotic colonization assessment, guiding clinical decisions regarding the timing of delivery and potentially informing antimicrobial interventions.
Social Norms Drivers on Public Good Contributions
Authors: Richefort Lionel , Pedehour Pauline 
Published: February 2025

ABSTRACTThis article develops a model of public good provision with social norms determined by network relationships. Individuals' wealth allocation preferences are guided by the benefit they obtain from a private good and a public good, and the social value they receive when following their neighbors in their contribution to the public good. We find conditions under which (i) redistributions of wealth will increase total giving if the transfer goes to the less norm‐conformist agent, (ii) an increase in tastes for conformity of the weak contributors will increase total giving, and (iii) the deletion of a link between two contributors will increase total giving. Subsequently, examples in very small networks allow us to discuss how these results can help policymakers encourage the voluntary provision of public good.