bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital breast tomosynthesis in mammographic screening: false negative cancer cases in the To-Be 1 trial
Authors: Moshina Nataliia , Gräwingholt Axel , Lång Kristina , Mann Ritse , Hovda Tone , Hoff Solveig Roth , Skaane Per , Lee Christoph I. , Aase Hildegunn S. , Aslaksen Aslak B. , Hofvind Solveig 
Published: February 2024

Abstract
Objectives
The randomized controlled trial comparing digital breast tomosynthesis and synthetic 2D mammograms (DBT + SM) versus digital mammography (DM) (the To-Be 1 trial), 2016–2017, did not result in higher cancer detection for DBT + SM. We aimed to determine if negative cases prior to interval and consecutive screen-detected cancers from DBT + SM were due to interpretive error.

Methods
Five external breast radiologists performed the individual blinded review of 239 screening examinations (90 true negative, 39 false positive, 19 prior to interval cancer, and 91 prior to consecutive screen-detected cancer) and the informed consensus review of examinations prior to interval and screen-detected cancers (n = 110). The reviewers marked suspicious findings with a score of 1–5 (probability of malignancy). A case was false negative if ≥ 2 radiologists assigned the cancer site with a score of ≥ 2 in the blinded review and if the case was assigned as false negative by a consensus in the informed review.

Results
In the informed review, 5.3% of examinations prior to interval cancer and 18.7% prior to consecutive round screen-detected cancer were considered false negative. In the blinded review, 10.6% of examinations prior to interval cancer and 42.9% prior to consecutive round screen-detected cancer were scored ≥ 2. A score of ≥ 2 was assigned to 47.8% of negative and 89.7% of false positive examinations.

Conclusions
The false negative rates were consistent with those of prior DM reviews, indicating that the lack of higher cancer detection for DBT + SM versus DM in the To-Be 1 trial is complex and not due to interpretive error alone.

Critical relevance statement
The randomized controlled trial on digital breast tomosynthesis and synthetic 2D mammograms (DBT) and digital mammography (DM), 2016–2017, showed no difference in cancer detection for the two techniques. The rates of false negative screening examinations prior to interval and consecutive screen-detected cancer for DBT were consistent with the rates in prior DM reviews, indicating that the non-superior DBT performance in the trial might not be due to interpretive error alone.

Key points
• Screening with digital breast tomosynthesis (DBT) did not result in a higher breast cancer detection rate compared to screening with digital mammography (DM) in the To-Be 1 trial.
• The false negative rates for examinations prior to interval and consecutive screen-detected cancer for DBT were determined in the trial to test if the lack of differences was due to interpretive error.
• The false negative rates were consistent with those of prior DM reviews, indicating that the lack of higher cancer detection for DBT versus DM was complex and not due to interpretive error alone.

Graphical Abstract
Existence of normalized solutions for Schrödinger systems with linear and nonlinear couplings
Authors: Yun Zhaoyang , Zhang Zhitao 
Published: February 2024

AbstractIn this paper we study the nonlinear Bose–Einstein condensates Schrödinger system $$ \textstyle\begin{cases} -\Delta u_{1}-\lambda _{1} u_{1}=\mu _{1} u_{1}^{3}+\beta u_{1}u_{2}^{2}+ \kappa (x) u_{2}\quad\text{in }\mathbb{R}^{3}, \\ -\Delta u_{2}-\lambda _{2} u_{2}=\mu _{2} u_{2}^{3}+\beta u_{1}^{2}u_{2}+ \kappa (x) u_{1}\quad\text{in }\mathbb{R}^{3}, \\ \int _{\mathbb{R}^{3}} u_{1}^{2}=a_{1}^{2},\qquad \int _{\mathbb{R}^{3}} u_{2}^{2}=a_{2}^{2}, \end{cases} $$

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Co-designing a personalised care plan for patients with rectal cancer: reflections and practical learnings
Authors: Gard Grace , Oakley Jo , Serena Kelsey , Gough Karla , Harold Michael , Gray Katya , Anderson Helen , Byrne Judi , Cockwill Jo , Down Graeme , Kiossoglou George , Gibbs Peter 
Published: February 2024

Abstract
Background
Consumer involvement is considered an essential component of contemporary cancer research, with a movement towards participatory methods, to the benefit of consumers and researchers. Overall, in-depth research on participant experiences and perceptions of their co-designer role—and how these may (or may not) change during a co-design project—is limited. The purpose of this paper was to synthesise the reflective accounts of consumers, project staff, and a researcher who partnered on a project to develop a personalised care plan template, with the aim of generating guidance for others looking to partner with consumers in health and medical research. Here, our team of researchers, project staff, and consumers reflect on the experience of working together using Gibbs’ Reflective Cycle, which was completed by team members with responses then undergoing inductive data analysis.

Results
Reflections are categorised under three core themes: (1) setting up the group and building relationships (2) measuring the value of consumer involvement, and (3) potential challenges for consumer involvement. Through reflection on our experiences of co-design, our team developed and identified practical strategies that contributed to the success of our partnership. These include setting expectations as a group; having experienced consumers on the team; having regular, pre-scheduled meetings that run to time; and working to overcome challenges identified by the group such as power imbalances, time commitment, and lack of diversity.

Conclusion
These practical reflections on creating a safe and supportive environment in which genuine consumer involvement can take place could inform other institutions and researchers looking to work meaningfully with consumers in research.
Availability and Geographic Access to Hospital-Based Breast Cancer Diagnostic Services in Ghana
Authors: Price Matthew D. , Rositch Anne F. , Dedey Florence , Mali Meghan E. , Brownson Kirstyn E. , Nsaful Josephine , Tounkara Mamadou , Price Raymond R. , Sutherland Edward Kofi 
Published: February 2024

PURPOSE Breast cancer is the most frequent cancer and second most common cause of cancer-related death in Ghana. Early detection and access to diagnostic services are vital for early treatment initiation and improved survival. This study characterizes the geographic access to hospital-based breast cancer diagnostic services in Ghana as a framework for expansion. METHODS A cross-sectional hospital-based survey was completed in Ghana from November 2020 to October 2021. Early diagnostic services, as defined by the National Comprehensive Cancer Network (NCCN) Framework for Resource Stratification, was assessed at each hospital. Services were characterized as available >80% of the time in the previous year, <80%, or not available. ArcGIS was used to identify the proportion of the population within 20 and 45 km of services. RESULTS Most hospitals in Ghana participated in this survey (95%; 328 of 346). Of these, 12 met full NCCN Basic criteria >80% of the time, with 43% of the population living within 45 km. Ten of the 12 met full NCCN Core criteria, and none met full NCCN Enhanced criteria. An additional 12 hospitals were identified that provide the majority of NCCN Basic services but lack select services necessary to meet this criterion. Expansion of services in these hospitals could result in an additional 20% of the population having access to NCCN Basic-level early diagnostic services within 45 km. CONCLUSION Hospital-based services for breast cancer early diagnosis in Ghana are available but sparse. Many hospitals offer fragmented aspects of care, but only a limited number of hospitals offer the full NCCN Basic or Core level of care. Understanding current availability and geographical distribution of services provides a framework for potential targeted expansion of services.
Building an Efficient Peritoneal Surface Malignancies Program Despite the Lower-Middle–Income Barriers: Ukraine Experience
Authors: Kopetskyi Viacheslav , Antoniv Marta , Yarema Roman , Maksymovskyi Viacheslav , Chetverikova-Ovchinnik Valeriia , Kryzhevskyi Vitalii , Volodko Nataliya , Gushchin Vadim , Nikiforchin Andrei 
Published: February 2024

PURPOSE Cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) programs are often limited to centers in developed countries because of extensive requirements. We aimed to analyze efficacy and challenges of CRS/HIPEC centers in lower-middle–income settings in the Ukraine example. METHODS A multicenter descriptive study was conducted using data sets (2008-2022) from Kyiv, Lviv, and Odesa centers. Patients with appendiceal neoplasm (AN); colorectal cancer (CRC); malignant peritoneal mesothelioma (MPM); and epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) treated with CRS ± HIPEC were included. Overall survival (OS) was analyzed for N ≥ 20 cohorts using the Kaplan-Meier method. RESULTS We included 596 patients. At Kyiv and Lviv centers, 37 and 28 patients with AN had completeness of cytoreduction (CC-0/1) rates of 84% and 71%, respectively. Thirty-day major morbidity stood at 24% and 18%, respectively. Median OS was not reached (NR) at both centers. Nineteen patients with CRC from Kyiv, 11 from Lviv, and 156 from Odesa had CC‐0/1 rates of 84%, 91%, and 86%, respectively. Thirty-day major complications occurred in 16%, 18%, and 8%, respectively. Median OS in the Odesa cohort was 35 (95% CI, 32 to 38) months. Among 15 Kyiv, five Lviv, and six Odesa patients with MPM, CC‐0/1 rates were 67%, 80%, and 100%, respectively, while major complications occurred in 13%, 0%, and 17%, respectively. OS was not analyzed because of small MPM cohorts. At Kyiv, Lviv, and Odesa centers, 91, 40, and 89 patients, respectively, had primary EOC. CC-0/1 rates were 79%, 100%, and 80%, and 30-day major morbidity rates were 23%, 5%, and 6%, respectively. Median OS was NR, 71 (95% CI, 32 to 110), and 67 (95% CI, 61 to 73) months, respectively. CONCLUSION CRS/HIPEC programs in lower-middle–income environment can achieve safety and survival that meet global standards. Our discussion highlights common obstacles in such settings and proposes effective overcoming strategies.
Defining the Educational Needs for a Community-Based Hematology/Oncology Career: A National Needs Assessment
Authors: Agrawal Shubham , Patell Rushad , Dodge Laura E. , Pegher Jennifer W. , Coleman Robert L. , Waterhouse David Michael , Roberts Daniel Aaron , Rangachari Deepa 
Published: February 2024

PURPOSE Little is known about the specific needs during training for hematology/oncology providers practicing in community-based settings. We conducted a national survey of hematologists/oncologists employed in community or academic-community hybrid settings to delineate their educational needs. METHODS An electronic questionnaire was developed and distributed nationally through professional organizations. We primarily assessed whether survey participants received any specific training during fellowship for community-based practice. Participants were also surveyed regarding training experiences that might have affected their preparation. Relative risk (RR) and 95% CI were calculated using modified Poisson regression to identify factors associated with receiving training specifically for community-based settings. RESULTS Of 125 participants from across 25 states, 63% were male and 58% identified as White. Less than half (41.6%, binomial 95% CI, 32.8 to 50.7) received any training in a community-based setting. Participants identified rotations in community settings (47%), direct mentorship from community-based physicians (40%), and longitudinal clinic in a community setting (36%) as experiences that would have been valuable. Specific curricula of interest included medical operations and administration (63%), health policy (35%), and quality improvement (27%). Respondents in clinical practice for <10 years were more likely to have received any training specifically for a community-based career (RR, 2.13 [95% CI, 1.18 to 3.86]). CONCLUSION Our study demonstrates substantial unmet needs as they relate to deliberately training fellows destined for community-based careers. Prospective design of clinical training and curricula emphasizing longitudinal exposures to and key aspects of health care delivery in the community setting are paramount to achieving optimal goal-concordant hematology/oncology training during fellowship.
Influence of TP53 Comutation on the Tumor Immune Microenvironment and Clinical Outcomes With Immune Checkpoint Inhibitors in STK11-Mutant Non–Small-Cell Lung Cancer
Authors: Naqash Abdul Rafeh , Floudas Charalampos S. , Aber Etan , Maoz Asaf , Nassar Amin H. , Adib Elio , Choucair Khalil , Xiu Joanne , Baca Yasmine , Ricciuti Biagio , Alessi Joao V. , Awad Mark M. , Kim Chul , Judd Julia , Raez Luis E. , Lopes Gilberto , Nieva Jorge J. , Borghaei Hossein , Takebe Naoko , Ma Patrick C. , Halmos Balazs , Kwiatkowski David J. , Liu Stephen V. , Mamdani Hirva 
Published: February 2024

PURPOSE Non–small-cell lung cancer (NSCLC) with STK11mut has inferior outcomes to immune checkpoint inhibitors (ICIs). Using multiomics, we evaluated whether a subtype of STK11mut NSCLC with a uniquely inflamed tumor immune microenvironment (TIME) harboring TP53 comutations could have favorable outcomes to ICIs. PATIENTS AND METHODS NSCLC tumors (N = 16,896) were analyzed by next-generation sequencing (DNA-Seq/592 genes). A subset (n = 5,034) underwent gene expression profiling (RNA-Seq/whole transcriptome). Exome-level neoantigen load for STK11mut NSCLC was obtained from published pan-immune analysis. Tumor immune cell content was obtained from transcriptome profiles using the microenvironment cell population (MCP) counter. ICI data from POPLAR/OAK (n = 34) and the study by Rizvi et al (n = 49) were used to model progression-free survival (PFS), and a separate ICI-treated cohort (n = 53) from Dana-Farber Cancer Institute (DFCI) was used to assess time to treatment failure (TTF) and tumor RECIST response for STK11mut TP53mut versus STK11mut TP53wt NSCLC. RESULTS Overall, 12.6% of NSCLC tumors had a STK11mut with the proportions of tumor mutational burden (TMB)-high (≥10 mut/Mb), PD-L1 ≥50%, and microsatellite instability-high being 38.3%, 11.8%, and 0.72%, respectively. Unsupervised hierarchical clustering of STK11 mut (n = 463) for stimulator of interferon-gamma (STING) pathway genes identified a STING-high cluster, which was significantly enriched in TP53mut NSCLC ( P < .01). Compared with STK11mut TP53wt, tumors with STK11mut TP53mut had higher CD8+T cells and natural killer cells ( P < .01), higher TMB ( P < .001) and neoantigen load ( P < .001), and increased expression of MYC and HIF-1A ( P < .01), along with higher expression ( P < .01) of glycolysis/glutamine metabolism genes. Meta-analysis of data from OAK/POPLAR and the study by Rizvi et al showed a trend toward improved PFS in patients with STK11mut TP53mut. In the DFCI cohort, compared with the STK11mut TP53wt cohort, the STK11mut TP53mut tumors had higher objective response rates (42.9% v 16.7%; P = .04) and also had longer TTF (14.5 v 4.5 months, P adj = .054) with ICI. CONCLUSION STK11mut NSCLC with TP53 comutation is a distinct subgroup with an immunologically active TIME and metabolic reprogramming. These properties should be exploited to guide patient selection for novel ICI-based combination approaches.
The Earth's Remembrance
Authors: Eliceche Cecilia Lisa 
Published: February 2024

Abstract
This conversation brings together Mapuche Weichafe and writer Moira Ivana Millán and Haitian art collector Houngan Jean-Daniel Lafontant. They reflect on the histories of colonialism and anticolonial resistance and discuss the workings of memory, embodiment, and territory, churches, museums, western science and forms of cultural, epistemic, and spiritual extractivism. Millán and Lafontant offer critiques of colonial violence and ongoing environmental destruction, which work together, they argue, to constitute a campaign of terracide that is still being waged on a planetary scale. They conclude by affirming collective struggles against this campaign and calling for a language beyond anthropocentrism.
Godse's Gandhi and Gandhi's Truth
Authors: Sawhney Simona 
Published: February 2024

Abstract
This essay considers the representation of Gandhi in the detailed statement given to the court by his assassin, Nathuram Godse, in 1948. It discusses how Gandhi was perceived by those who wished to re-create Hinduism as a modern political ideology. Juxtaposing the views of Godse and his political mentor, V. D. Savarkar, with those of Gandhi, the essay focuses on the overdetermined invisibility or illegibility of Gandhi's conceptions of truth, religion, and political community in the discourse of the Hindu right. A bleak realization regarding the contemporary extent of this illegibility drives this essay. While the radically egalitarian potential of Gandhi's language has not been substantively inherited by any significant group in the political sphere today, Godse's language has found many heirs in India as well as in other countries.
Driving autophagy – the role of molecular motors
Authors: Nambiar Akshaya , Manjithaya Ravi 
Published: February 2024

ABSTRACT
Most of the vesicular transport pathways inside the cell are facilitated by molecular motors that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that is initiated by the formation of an isolation membrane known as the phagophore, which expands to form a double-membraned structure that captures its cargo and eventually moves towards the lysosomes for fusion. Molecular motors and cytoskeletal elements have been suggested to participate at different stages of the process as the autophagic vesicles move along cytoskeletal tracks. Dynein and kinesins govern autophagosome trafficking on microtubules through the sequential recruitment of their effector proteins, post-translational modifications and interactions with LC3-interacting regions (LIRs). In contrast, myosins are actin-based motors that participate in various stages of the autophagic flux, as well as in selective autophagy pathways. However, several outstanding questions remain with regard to how the dominance of a particular motor protein over another is controlled, and to the molecular mechanisms that underlie specific disease variants in motor proteins. In this Review, we aim to provide an overview of the role of molecular motors in autophagic flux, as well as highlight their dysregulation in diseases, such as neurodegenerative disorders and pathogenic infections, and ageing.
Ultrastructural organization of alveolar macrophages during late development of experimental acute pancreatitis
Authors: Zaiats Liubomyr , Pasichnyk Olga , Zukow Walery 
Published: February 2024

Background. Nowadays, acute pancreatitis continues to remain an actual problem both in surgery and in intensive care medicine. The aim of the work was to study the dynamics of ultrastructural changes of alveolar macrophages in the long-term development of experimental acute pancreatitis. Material and methods. The experiments were carried out on 62 white Wistar male rats weighing 180–220 g. The animals were divided into three groups: first — intact, second — control, third — experimental with a model of acute pancreatitis, which was reproduced by intraperitoneal administration of a 20% solution of L-arginine in a total dose of 5 g/kg at one-hour interval. The control group of animals was intraperitoneally injected with an equivalent dose of isotonic sodium chloride solution. All research were performed under sodium thiopental anesthesia at the rate of 60 mg/kg body weight. Lung tissue for electron microscopic examination was collected from the lower lobe of the left lung at 3–5 and 7 days. Pieces of lung tissue measuring 1×1×1 mm were fixed in a 2.5% glutaraldehyde solution, followed by additional fixation in a 1% osmium tetroxide solution. After dehydration, the material was poured into Epon-Araldite. Sections with a thickness of 20–50 nm obtained on “Tesla BS-490” ultramicrotome were studied in a PEM-125K electron microscope. Results. It was found that three days after the start of the study, significant heterogeneity of alveolar macrophages was observed in the alveolar lumen. Next to active phagocytic macrophage elements with dystrophic-destructive changes are determined. Continuation of the experiment (5 days) leads to the progression of submicroscopic changes in alveolar macrophages, which are most pronounced on the7 day of the study. Conclusion. Acute experimental pancreatitis is accompanied by pronounced changes in the ultrastructural structure of alveolar macrophages. The features and severity of structural changes in alveolar macrophages depends on the duration of arginine-induced acute pancreatitis.
Takeover Protections and Asset Prices
Authors: Eisdorfer Assaf , Morellec Erwan , Zhdanov Alexei 
Published: February 2024

We study the effects of takeover feasibility on asset prices and returns in a unified framework. We show theoretically that takeover protections increase equity risk, stock returns, and bond yields by removing a valuable put option to sell the firm, notably for firms approaching distress. We investigate these claims empirically and find that distressed firms experience a significant decrease in value and increase in returns and market betas after the passage of antitakeover laws, in line with our predictions. At issue bond yields are also higher when an antitakeover law is in effect. Consistent with the model, the effects of antitakeover laws on stock returns, respectively, bond yields, are greater when shareholders, respectively, bondholders, have greater bargaining power. This paper was accepted by Lukas Schmid, finance. Funding: E. Morellec acknowledges financial support from the Swiss Finance Institute. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03111 .
Eco-logie in conflitto il «Chipko» da protesta contadina a icona ambientalista.
Authors: Riva Federica 
Published: February 2024

The article explores different cultural perceptions of food in relation to the environment. ‘Farmers’ and ‘ecologists’ are often actors of contrasting eco-logics: antithetic visions of the environment, as rural landscape or wilderness, define the right or ban of people to get access to the natural resources as commons in order to produce livelihood.
Taking the Chipko andolan, movement that hugs (for the strategy of hugging trees in order to prevent them from being cut), as focus for my anthropological analysis, I consider the process of cultural transformation of the peasant protest, born in the Indian Himalayas in the 70’s, into an ecologists myth for urban and western audience.
The achieved visibility of Chipko on a global stage has become a translation of the people’s requests for the decentralization of forest management into a conservationist claim to protect trees. Beginning with my fieldwork in Tehri Garhwal (Uttarakhand), I have tried to bring the Chipko back to the Himalayan taskscape (Ingold T. 1992) to the everyday relations of the farmers with an environment which not easy to tame.
On the other hand, I analysed the rhetorical strategies used by some Chipko’s spokesmen and that has allowed the appropriation of the movement by the ecologist imaginary. The ‘local’ and the ‘global’ are at the very heart of what the movement has become; a continuous interaction between the two that has shaped the actuality of Himalayan landscape.