bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Outcome and Prognostic Factors of Remnant Gastric Cancer: A Propensity Score-Matched Analysis
Authors: Yan Shangcheng , Shao Qiankun , Peng Wei , Cheng Ming , Liu Tianhua , Sheng Mengchao , Ren Rui , Chen Qiang , Gong Wei , Wu Yongyou 
Published: December 2023

Abstract

Purpose.
Studies on survival and prognostic factors in individuals with remnant gastric cancer (RGC) after gastric cancer (GC) are rare. It is debatable whether prognosis of RGC after GC is worse than that of only primary gastric cancer (OPGC).
Methods.
We retrospectively collected data from the Surveillance, Epidemiology, and End Results database among patients who underwent GC surgery in 1988–2020. Propensity score matching (PSM) was conducted to balance baseline characteristics. Kaplan-Meier survival analysis was performed to compare their overall survival (OS) and disease-specific survival (DSS). Multivariable Cox analyses were performed to identify the independent prognostic factors for RGC.
Results.
76 patients with RGC and 32763 patients with OPGC were included and analyzed. After balancing the baseline characteristics by PSM, no significant difference existed between OPGC and RGC groups in both OS (p = 0.65) and DSS (p = 0.35). Fixed-time analyses also showed no difference between the two groups for the 5-year (60.0%, RGC vs. 53.3%, OPGC, p = 0.38) and 10-year DSS (56.7%, RGC vs. 48.3%, OPGC, p = 0.34) DSS. Multivariate analysis revealed that area of lower income (<$55000), cardiac tumor, deeper invasion (T3-4), higher grade (G3) and not receiving chemotherapy were independent risk factors for DSS in patients with RGC.
Conclusion.
The prognosis of RGC following GC was comparable to that of OPGC. The independent prognostic factors for RGC are similar to those established for OPGC. Our findings suggest that RGC might be the same entity to OPGC and curative resection should be considered in selected patients.
Identifying the causal relationship between immune factors and osteonecrosis: A Two-Sample Mendelian Randomization Study
Authors: Wang Chao , Zhu Yong , Pan Ding 
Published: December 2023

Abstract

Backgrounds: A wealth of evidence intimates a profound connection between the immune system and osteonecrosis, albeit the specific immune factors underlying this connection remain largely veiled. Methods A bidirectional Mendelian randomization (MR) study was conducted based on genome-wide association study (GWAS) summary data to identify causal links between 731 immune factors and osteonecrosis including drug-induced osteonecrosis. Preliminary MR analysis was accomplished utilizing the inverse-variance weighted method (IVW) under a multiplicative random effects model, and heterogeneity and potential horizontal pleiotropy were evaluated through Cochrane's Q-test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis. Results Upon false discovery rate correction, the gene-predicted level of one immune factor (CD62L- monocyte %monocyte) exhibited a significant positive correlation with osteonecrosis, while eight immune traits associated with monocytes, dendritic cells, and NK cells demonstrated significant causal effects with drug-induced osteonecrosis. Reverse MR revealed no significant correlations. Conclusion This MR research provides genetic evidence for the causal associations between a broad spectrum of immune factors and osteonecrosis. Such a study aids in unraveling the intricate interaction patterns between the immune and skeletal systems, elucidating the pathogenesis of osteonecrosis, and identifying potential novel therapeutic approaches.
Heart rate variability analysis at admission in the ICU of Covid-19 patients cannot predict invasive mechanical ventilation need: a prospective study
Authors: Fariña-González Tomás Francisco , Martinez-Sagasti Fernando , Hernando Maria Elena , Oropesa Ignacio , González-Gallego Miguel Angel , Nuñez-Reiz Antonio , Quintana-Diaz Manuel 
Published: December 2023

Abstract
PURPOSE: cardiovascular response to stress (such as hypoxemia) is mediated by the autonomic nervous system (ANS) and heart rate variability is an important part of it. Neurotropism is an important feature of SARS-CoV-2 infection and clinical dissociation between hypoxemia and the cardiovascular response has been reported. We proposed that HRV could be used to identify, at admission in the intensive care unit (ICU), those patients who were going to need invasive mechanical ventilation (IMV) during their stay.
METHODS: We performed a prospective single-centre observational study analyzing adult patients admitted to ICU at Hospital Clínico San Carlos with respiratory failure due SARS-CoV-2 pneumonia but not under IMV. We recorded continuous EKG waveforms and obtained time and frequency domains and non-linear dynamics HRV metrics.
RESULTS: 47 patients were screened and 27 were finally analyzed. 15 (55.5%) of them required intubation and IMV. Heart rate was 80 beats/min in each group. HRV metrics were similar between groups in the time domain, frequency domain and after using nonlinear analysis. However, when comparing against literature control, Covid-19 patients admitted in the ICU had a diminished HRV but higher heart rates.
CONCLUSION: We found that HRV on ICU admission didn't discriminate patients requiring IMV. We found that Covid-19 patients had a diminished HRV although having higher heart rates than healthy literature controls.
Productivity, Markups, and Reallocation: Evidence from French Manufacturing Firms from 1994 to 2016
Authors: De Monte Enrico 
Published: December 2023

Abstract

This paper investigates the evolution of aggregate productivity and markups among French manufacturing firms between 1994 and 2016, by focusing on the role of reallocation with respect to both aggregate measures. Firm-level productivity and markups are estimated based on a gross output translog production function using popular estimation methods. I find an aggregate productivity growth of about 34\% over the whole period while aggregate markups are found to remain relatively stable. As a key finding the study shows that over time reallocation of sales shares affects differently aggregate productivity and markups: Before 2000 both aggregate productivity and markups are importantly driven by reallocation effects; Post-2000, instead, the contribution of reallocation to aggregate productivity becomes negligible, inducing a slowdown in aggregate productivity growth, while I measure persistent reallocation of sales shares from lower to higher markup firms. Policy relevant implications of these dynamics are discussed.
JEL Classification: C13; D21; D24; L16; L60; O47
Study on the expression of IgG in prostate cancer and its effect on prostate cancer
Authors: Xia Hongmei , Lin Canling , Zhang Feng , Luo Xiaojin , Yin Weihua 
Published: December 2023

Abstract
Prostate cancer (PC) is the second leading cause of cancer-related death in men. Recent studies have discovered immunoglobulin G (IgG) in the progression and pathogenesis of various cancers. This study aimed to explore the role of IgG in PC. By immunohistochemistry, IgG was found to be highly expressed in PC tissues. In addition, we assessed whether intervention with the PI3K-Akt pathway inhibitor pimasertib can improve the immune function of patients. IgG-FCGR1A small interfering RNA (siRNA) was used to silence IgG expression in PC3 and C4-2 cells. The efficiency of IgG knockdown was confirmed using Western blotting. The effects of Akt pathway inhibitors on the apoptosis of PC-3 and C4-2 prostate cancer cells and on the SOX2/HIF-1α pathway were also assessed by RT-PCR. PC3 cells transfected with or without IgG-FCGR1A short hairpin RNA (shRNA) were injected subcutaneously into the flanks of 6-week-old male nude mice to establish a xenograft mouse model. The elimination of IgG significantly inhibited the proliferation of PC3 and C4-2 cells and the expression of IgG protein in vitro. Similarly, in vivo studies showed that IgG knockout significantly reduced tumour volume of nude mice. IgG plays an important role in the growth of PC and may be a target for PC treatment, providing information for clinical research on PC.
Artwork’s Authenticity Recognition Model Using Machine Vision and Applications
Authors: Mirbod Majid 
Published: December 2023

Abstract
This paper presents an artwork authenticity recognition model using machine vision, image processing, and a fuzzy interface system and it is an applied research category. Artworks have always been subject to copying due to their importance, uniqueness, and great financial value, and it has always been the focus of international counterfeiters worldwide. Throughout history, due to various incidents, artworks have been stolen, crossed the borders of different countries, and traded in various auctions. Therefore, recognizing and confirming an artwork's authenticity is always challenging. In this research, I try to present a model to verify the authenticity of artwork using artificial intelligence techniques. The basic assumption is that a quality image of the original artwork is available with the specifications that I will explain in the section. Indeed, two images will be compared by taking pictures of other samples, and their differences will be identified with high accuracy, which the human eye cannot recognize. So, this model cannot recognize artwork authenticity without imaging history. In other words, photographing the original artwork can be used as a basis for comparison with other fake copies of it in the future, and by using the proposed model, their authenticity can and will always be checked. This model is based on my previous research on micrographics imaging to Industrial parts change recognition, the details of which will be explained in the text of the article. In this research, seven unique and famous artworks of the world were used and two samples of their images were compared to the original sample. The validity and reliability of the results and the high accuracy were obtained with one pixel.
Tara: Streamlining DSL Development through Syntactic Patterns
Authors: Andrés Octavio Roncal , Cabrera José Juan Hernández , Gómez José Évora 
Published: December 2023

Abstract
This article introduces a method designed to simplify the development of domain specific languages (DSLs). We aim to address challenges associated with designing and implementing DSLs, advocating an approach that combines the strengths of both internal and external types. Central to our proposal is Tara, a mother language designed to provide the foundational structure upon which DSLs can be specialized. Based on an analytical framework, Tara includes a set of syntactic patterns that seeks to represent a wide range of domains. The use of syntactic patterns in DSL development appears to mirror software design patterns, offering similar benefits in terms of communication, readability, and maintainability. We believe that by adopting these patterns, DSL development can be streamlined and made more efficient. Furthermore, the benefits of integrating these syntactic patterns, not only enhance efficiency but also ensure greater consistency among DSLs.
Multivariate Analysis in Spring Wheat (Triticum aestivum L.) as predicted by Agronomist.
Authors: Wahid Muhammad Atif , Wahid Kashif 
Published: December 2023

Abstract
Assessment of genetic diversity is necessary for any breeding programme to increase world’s food by gathering different favorable genes resulted from segregant generations. The present study was designed to find diversity patterns among fourteen lines of hexaploid wheat (Triticum aestivum L.). Nine quantitative traits were determined phenotypically. Moreover grain properties and nutritional quality were also determined by laboratory procedures. Cluster analysis based on squared Euclidean distance and ward's linkage method, categorized the cultivars into four groups. Based on Principal Component Analysis (PCA), the first seven components explained over 88% of genetic variation. Cluster analysis based on PCA using the first seven principal components indicated four separate groups of genotypes, with the maximum genetic distance observed between genotypes in each cluster. Grain diameter, grain weight, gluten content, protein content, fiber, fat and starch contributed towards significant principal components (PCs). 88146, Fareed-06, 6317 and 88132 were concluded as more diverse parents. Diverse parents from various clusters are helpful in planning and broadening the breeding programme especially for grain quality in Pakistan.
High flexural modulus of PLA composites for FDM 3D printing using multifunctional octaspherosilicates
Authors: Sztorch Bogna , Głowacka Julia , Romanczuk-Ruszuk Eliza , Brząkalski Dariusz , Marciniec Bogdan , Przekop Robert E. 
Published: December 2023

Abstract
This work extends prior investigations into creating a new nanocomposite using modified silsesquioxanes and spherosilicates. These modifiers are used as additives to PLA to manage its properties specifically for FDM 3D printing. Following the chemical composition and the ratio of functional groups, the miscibility and reactivity of the additives in the polymer matrix, their effect on the rheology and mechanical properties of the material, and the water contact angle of the surface can be controlled. The most important aspect is achieving better melting of the material during printing, which, combined with the appropriate printing parameters, can ultimately produce more robust objects with fewer voids and discontinuities.
Generation and characterization of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Authors: Majid Qasim A. , Ghimire Bishwa R. , Merkely Bela , Randi Anna M. , Harding Sian E. , Talman Virpi , Foldes Gabor 
Published: December 2023

Abstract

Cardiac microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro investigation of CMD requires a robust cell model that faithfully represents the cells within the cardiac microvasculature. Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) offer great potential; however, they are traditionally derived via differentiation protocols that are not readily scalable and are not specified towards the microvasculature. Here, we report the development and comprehensive characterization of a scalable 3D protocol enabling the generation of phenotypically stable cardiac hPSC-microvascular-like ECs (hPSC-CMVECs) and cardiac pericyte-like cells. These were derived by growing vascular organoids within 3D stirred tank bioreactors and subjecting the emerging 3D hPSC-ECs to high-concentration VEGF-A treatment (3DV). Not only did this promote phenotypic stability of the 3DV hPSC-ECs; single cell-RNA sequencing (scRNA-seq) revealed the pronounced expression of cardiac endothelial- and microvascular-associated genes. The generated mural cells attained from the vascular organoid exhibited markers characteristic of cardiac pericytes. We present a suitable cell model for investigating the cardiac microvasculature as well as the endothelial-dependent and -independent mechanisms of CMD. Further, owing to their phenotypic stability, cardiac specificity, and high angiogenic potential, the cells described within would also be well suited for cardiac tissue engineering applications.
Cattle grazing and herbaceous competition shape woody seedling establishment across environmental gradients in Neotropical savannas
Authors: Mochi Lucía Sol , Aguiar Martín Roberto , Aranda Melina Jeanette , Biganzoli Fernando , Mazía Noemí 
Published: December 2023

Abstract
Woody encroachment in savannas is a complex and global phenomenon that has negative impacts on the forage availability and livestock yield. We examined the impact of cattle grazing and herbaceous vegetation on Vachellia caven and Vachellia aroma, the main encroacher tree species in Neotropical savannas, where livestock production is the principal activity. Our experiments were conducted across a gradient of aridity and productivity (low-, medium-, and high-productivity sites), covering the central distribution of savannas in Argentina. We carried out manipulative experiments with cattle grazing (grazed–ungrazed) and herbaceous vegetation (with–without) to examine Vachellia seed loss (e.g. granivory), seedling emergence, survival, growth, and establishment. In the medium-productivity site, seed loss was higher under ungrazed conditions with herbaceous vegetation. Across all sites, cattle grazing decreased the final seedling survival regardless of the presence of the herbaceous vegetation. Herbaceous vegetation increased tree seedling survival in the medium-productivity site but decreased it in the low- and the high-productivity sites. Overall, the effect of grazing on tree establishment was neutral in the medium-productivity site as a consequence of increasing seed availability and decreasing seedling survival. However, seedling establishment was higher under ungrazed conditions and without herbaceous vegetation in the high- and low-productivity sites, because of the negative effects of grazing and herbaceous vegetation on seedling survival. From this demographic approach, we identified an ecological window during which grazing could be effectively managed to control the early stages of woody encroachment if stocking is adjusted and synchronized with tree species life history and site productivity.
Assessing Underutilization of Mental Health Resources at a Historically Black College and University (HBCU)
Authors: Ayyad Ahlam A. , Maestri Thomas J. , Harris Savannah , Casanova Nina , Ibrahim Hanan 
Published: December 2023

Abstract
Objective:
In 2018, a survey was conducted with students on a Historically Black College and University (HBCU) campus that showed a significant lack of utilization of both on and off campus mental health resources. The primary outcome of this survey is to evaluate lack of utilization of mental health resources at an HBCU to effectively promote student mental wellness.
Methods:
A short electronic survey was administered to students to assess underutilization.
Results:
Subjects were predominately African American (60.24%) and female (85.53%). Of the 159 surveys completed, 13 responded they have used on campus mental health resources. Approximately 61.5% (8/13) are satisfied or very satisfied with the services. 29 responded they have used off campus mental health resources. Approximately 41.4% (12/29) are satisfied or very satisfied with the services. 62 (39%) responded that time constraint was a barrier faced in utilizing mental health resources. 60 (38%) responded that they did not feel that mental health resources were currently needed. 40 (25%) responded that they were not aware of mental health resources available. There is a significant association between classification and comfort level continuing to utilize mental health resources on or off campus (p = 0.02).
Conclusions:
There are multiple barriers that have attributed to the underutilization of mental health resources. According to the results of this survey, the majority of students lacked time to utilize or denied need for any mental health resources. These results will allow for an opportunity to improve utilization of both on and off campus mental health resources.
Preparation of the Electrospun Composite Nanofibers for Oils Absorption.
Authors: Habeeb Salih Abbas , Nadhim Baseem Ali 
Published: December 2023

Abstract
In this study, polymeric materials that absorb oils floating on the surface of the water, such as paraffin oil, engine oil, and transmission oil, were prepared by electrospinning. The sorbent comprises Polyvinyl chloride (PVC)/polystyrene (PS) nanofibers. The blend nanofibers were strengthened by (2.5,3.5.4.5, and 5.5) wt.% of Zirconia. Various physical tests were conducted on prepared nanofibers as Field Emission Scanning Electron Microscopy (FE-SEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and contact angle for water and oil. The results showed that the nanofiber diameters and average pore size reduction were 31.87 and 65.94%. In comparison, the increment in the overall porosity was 33.1% when reinforcing the PVC: PS nanofibers by 5.5 wt.% zirconia. Zirconia nanoparticles improve the crystalline and thermal properties, besides increasing the wettability of surfaces of polymeric absorbs by using water or oils. The absorption capacity of oil is much greater than the absorption capacity of water, and the absorption capacity of nanofibers reinforced with zirconia is higher than that of nanofibers of PVC: PS. The highest selectivity of transmission oil absorption by composite nanofibers indicated ease of separating the oils from the water surface.
Preliminary adaptation process of cognitive behavior therapy for major depression in Bangladesh: A pilot study
Authors: Ara Jesan , Deeba Farah 
Published: December 2023

Abstract

Being developed and modified in the Western world, the cultural values and communities influence cognitive behavioural therapy (CBT) strongly. In this study, CBT was adapted in Bengali to see the functional feasibility of CBT for persons with depression in Bangladesh. This is the first pilot study for an adapted CBT manual for on psychological intervention for working with depressive clients in Bangladesh. There were three phases of the study; in the first two phase’s adaptation of the standard protocols of CBT for the Bangladeshi community, as practiced by mainstream practitioners and mental health professionals in the world were ensured. Information gathered during first phase on the standard protocols of CBT was written up as the first draft of the adapted CBT manual in Bengali. In the second phase, the CBT manual was given to seven senior clinical psychologists in Bangladesh who train CBT to fellow mental health professionals for evaluation. After synthesizing the judge’s comments and suggestions the draft of the Bengali CBT manual was finalized. In the third phase, to evaluate the functional feasibility of the Bengali CBT-based manual, five diagnosed patients with depression referred by the psychiatrists were tested. Four valid and reliable psychometric measurements were used to measure symptoms of depression and comorbid symptoms of anxiety, psychological distress, and suicidal risk. Assessments were completed at 2 time points (pre-test and post-test) using the scales. The intervention was delivered over 6–10 sessions and improvements were found on the scores of all questionnaires. The possibilities of Bengali CBT to reduce depression and appearing to be a promising treatment option for depression are discussed in the paper.