bluuebunny/crossref_metadata_2025_split huggingface dataset:
The results of hemostasis assessment using thromboelastography in patients with COVID-19
Authors: Gorodin V. N. , Moysova D. L. , Surkova A. D. 
Published: October 2023

All currently existing studies of the hemostasis system in COVID-19 using thromboelastography (TEG) were performed on the delta strain of SARS-CoV-2, while there is no information in the literature on conducting such studies in patients infected with the current omicron strain.Research objective. To determine the state of the hemostasis system in hospitalized patients with COVID-19 (omicron strain) using TEG. To assess the relevance of existing guidelines on anticoagulant therapy.Materials and methods. TEG was performed in 93 hospitalized patients with COVID-19 aged 1 to 88 years, of which 66 patients (group 1) on the first day and 27 patients (group 2) – on the second day. For comparison with the parameters of healthy volunteers, a sample of 30 people was formed. Data analysis was performed using the Statistica, version 12 (StatSoft, USA). To compare the independent variable in more than two samples, a multivariate ANOVA analysis of variance was performed with the calculation of the Kruskal-Wallis test. To assess the relationships between continuous variables, the Spearman direct linear correlation coefficient (r) was determined.Results. 53% of patients had hypocoagulation, 31% had normocoagulation, and 16% had hypercoagulation. Elderly patients (61 [26–72]) more often have developed hypocoagulation. Young patients (24.5 [7–37]) more often have developed hypercoagulation. Routine methods for assessing hemostasis did not reflect its true state. Higher levels of fibrinogen (4.5 [5.8–4] g/l) and D-dimer (1.28 [0.5–2.77] µg/ ml) were observed in patients from the group with normocoagulation. Was revealed a statistical tendency towards an increase in the level of amylase when there was an increase in the coagulation properties of the blood.Conclusion. With the current course of COVID-19 and early admission of non-severe patients to the hospital, normocoagulation and hypocoagulation predominate. Elderly and senile patients are not recommended to prescribe anticoagulants without TEG. It is necessary to specify the recommendations for prescribing anticoagulants to hospitalized patients. For the diagnosis of hemostasis disorders expand application of TEG.
An artificial intelligence approach for prognosis of COVID-19 course in hospitalized patients
Authors: Karonova T. L. , Korsakov I. N. , Mikhailova A. A. , Lagutina D. I. , Chernikova A. T. , Vashukova М. A. , Smolnikova M. A. , Gusev D. A. , Konradi A. O. , Shlyakhto E. V. 
Published: October 2023

Aim. To create algorithm and risk calculator for predicting the lethal outcome in patients with COVID-19.Materials and methods. Based on machine learning approach mortality risk calculator was developed in Almazov National Medical Research Centre using data of the hospitalised patients with an established diagnosis of COVID-19 (n=4071).Results. This mathematical model, which includes 11 significant features, has been proposed for estimation of fatal outcomes in the Clinical Infectious Hospital named after S.P. Botkin. Some key features were not assessed in most hospitals according to accepted standards of care for COVID-19. So systematic analysis of factors affecting the course of disease in patients (n=2876) were conducted and «urea» and «total protein» were replaced with «sex» and «BMI». Modified algorithm demonstrated high sensitivity and specificity. Conclusion. This calculator is able to predict hospitalisation outcome with high accuracy in patients infected with different strains of SARS-CoV-2. This decision support system may be used for risk stratification and following correct patients routing.
Teoria do desemprego novo-keynesiana:
Authors: Diniz Maia Francisco Thainan 
Published: October 2023

Resumo: O artigo discorrerá sobre a influência do pensamento da escola neokeynesiana na Reforma Trabalhista de 2017 e sobre o posicionamento dos últimos governos brasileiros na gestão econômica. Serão apresentados os pressupostos teóricos dessa escola, bem como as limitações intrínsecas ao seu pensamento, sob a luz dos argumentos pós-keynesianos; por fim, serão apresentados os resultados práticos da reforma e das políticas macroeconômicas, relacionando-os com as críticas apresentadas ao longo do trabalho, desenvolvendo a hipótese de que os pressupostos teóricos neokeynesianos não são adequados para a economia brasileira em sua dinâmica subdesenvolvida.
Palavras-Chave: Neokeynesianismo; geração de empregos; macroeconomia; reforma trabalhista; Rigidez de salários;
Designing a Mobile-Based USAKTI on APP using The User Centered Design (UCD) Method
Authors: Shofiati Ratna , Pramono Muhammad Rafiansyah , Sediono Agung 
Published: October 2023

Usakti On APP merupakan aplikasi sistem informasi akademik yang dimiliki Universitas Trisakti. Aplikasi tersebut ada di platform mobile android dan juga website. Aplikasi yang berjalan di website melibatkan pengguna semua sivitas akademika. Aplikasi mobil awalnya bertujuan untuk mempermudah mahasiswa untuk melakukan pengecekan nilai dan krs. Kondisi tampilan user (user interface) dari Usakti On App masih kurang informatif dan terlihat kurang menarik, warna pada aplikasi kurang kontras dan kurang nyaman untuk mata, sehingga informasi yan disajikan menjadi tidak jelas. Oleh karena itu perlu adanya perbaikan alur sebuah system dengan menerapkan metode User Centered Design (UCD) pada perancangan system Usakti On App. Prototipe dibuat dengan Figma untuk menghasilkan rancangan yang high fidelity yaitu rancangan yang sangat mirip dengan hasil akhirnya. Hasil evaluasi dengan SUS didapatkan bahwa system yang baru mendapatkan skor rata-data 80,86 yaitu setingkat baik atau “good”
جودة الخدمة وأثرها في تعزيز العلامة التجارية: دراسة وصفية لعينة من زبائن شركة آسياسيل في صلاح الدين
Authors: خطاب مهران محمود , ويردي نجاح مدد 
Published: October 2023

هدفت الدراسة الحالية إلى تحديد تأثير جودة الخدمة من خلال أبعادها (الاعتمادية، الاستجابة، جودة الشبكة، التعاطف، الأمان) في العلامة التجارية كمتغير تابع من خلال أبعادها (السعر المدرك، الجودة المدركة، الولاء للعلامة). تم استخدام المنهج الوصفي التحليلي في تفسير وتحليل البيانات التي تم الحصول عليها من الميدان المبحوث باستخدام الاستبانة كأداة رئيسية لجمع البيانات. تمثل مجتمع الدراسة بزبائن شركة (آسياسيل) في محافظة صلاح الدين، أما عينة الدراسة فقد شملت (380) مفردة تم اختيارهم عشوائياً من زبائن الشركة، وقد تم توزيع استبانة الكترونيه على عينة الدراسة والحصول على نسبة إجابة (100%).
خلصت الدراسة إلى أن تقييم الزبائن لجودة خدمات الشركة إيجابي وجيد لكنه لا يصل إلى مستوى توقعاتهم. وأشارت نتائج الدراسة أيضاً إلى أن الزبائن يولون أهمية لأبعاد جودة الخدمة وخاصة فيما يتعلق بالاستجابة لمشاكل وشكاوى الزبائن كما اشارت الدراسة إلى وجود علاقة أثر ايجابية لأبعاد جودة الخدمة في العلامة التجارية للشركة.
Trajectory Synthesis for the Coordinated Inspection of a Spacecraft with Safety Guarantees
Authors: Hibbard Michael , Cubuktepe Murat , Shubert Matthew , Lang Kendra , Topcu Ufuk , Phillips Sean 
Published: October 2023

As outer space becomes increasingly congested, there exists a growing need for auxiliary spacecraft to perform support missions for existing satellites with guarantees for safety and mission success. We focus on a multispacecraft inspection mission, wherein a team of “deputy” spacecraft inspect a passive “chief” spacecraft by traveling to a set of inspection points while satisfying a set of safety constraints, namely, that they avoid aligning themselves with the sun, that they avoid colliding with one another, and that they avoid colliding with the chief. We model the deputy dynamics using the Clohessy–Wiltshire–Hill equations, and subsequently discretize the environment by exploiting elliptical natural motion trajectories. Using this finite state space, we construct a Markov decision process (MDP) model of the environment and determine the optimal sequence of inspection points for each deputy to visit by solving a vehicle routing problem. To ensure that the deputies satisfy the safety constraints, we form the product MDP of the original MDP and a nondeterministic Büchi automaton that encodes the sensing task and safety constraints. Using this product MDP, we propose a pair of decentralized algorithms that each seeks to minimize the weighted combination of the time and fuel required to safely complete the mission. The first is an offline algorithm that synthesizes a safe trajectory for each deputy that requires no communication at runtime, while the second is an online algorithm that enforces safety at runtime by leveraging communication between the deputies. We provide numerical examples demonstrating the efficacy of both proposed algorithms.
The pattern of ocular disorders in eye patient attendants in tertiary eye care centers
Authors: Khan Aiman , Singh Mahendra 
Published: October 2023

Objectives:
This study aims to assess the pattern of ocular disorders in patient attendants at tertiary eye care centers.

Materials and Methods:
A cross-sectional study has been conducted at a tertiary eye care center in northern India. The study participants were adults aged 18 years who came along with patients. The study duration was from September 2022 to March 2022. This study was conducted to assess the ocular disorder inpatient attendant. The survey methods included the Bruckner test and torchlight examination.

Results:
A total of 202 subjects were assessed in our study. Of them, 71 (35.1%) were diagnosed with emmetropia. Refractive errors for distance were reported in 120 (59.4%) attendants. Of them, 104 (51.4%) did not have any previous eye disease, 81 (77.88%) were unaware, and 23 (22.11%) were aware of their ocular disorder.

Conclusion:
The majority of attendants who did not have any ocular symptoms and also never underwent any eye examination were suffering from eye disease. We found that there was a high significance between attendant ocular symptoms (without previous examination) and awareness (P = 0.05).
Knowledge exchange seminar series – session 4: Patient expert training
Authors: Gudlavalleti Anirudh Gaurang , McGuire Hugh , Rasburn Mark 
Published: October 2023

Introduction:
A second knowledge exchange seminar series was organised as a part of the collaborative project between NICE International and Indian health outcomes, public health and economics research centre (IHOPE) to develop and implement evidence-based clinical guidelines in India. The training of patient experts as a part of the committee is an important step in any committee’s development.

Aim:
To describe how IHOPE plans to provide training to patient representatives on its guideline committees.

Conclusion:
Continuous feedback from patient experts improves their experience of working in guideline committees and helps keep the training provided to all patient experts relevant and current.
Pengembangan Sistem Isyarat Kunci Komunikasi Sosial Bagi Peserta Didik Multi Disabilities With Visual Impairment
Authors: Oktavianti Rossea Nur , Sudarto Zaini , Budiyanto Budiyanto 
Published: October 2023

Permasalahan utama peserta didik MDVI yakni pada aspek berkomunikasi khususnya dalam mengungkapkan kebutuhan dasar sehari-hari. Tidak semua dapat memahami apa yang sedang diinginkan anak MDVI, sehingga orang tua selalu mendampingi putranya di sekolah, karena mereka sedikit banyak memahami isyarat/clue komunikasi anaknya. Tujuan dari penelitian ini untuk menghasilkan produk berupa desain cara atau strategi komunikasi sosial untuk pemenuhan dalam mengungkapkan kebutuhan dasar MDVI dengan merujuk pada hal yang sudah dikenali dan disenangi anak berupa isyarat kunci kebutuhan dasar (makan, minum, tidur, berpakaian, toileting). Penelitian ini menggunakan desain pengembangan ADDIE dari Branch 2010 yang dimodifikasi hanya dibatasi pada tahap Pengembangan (development). Teknik pengumpulan data meliputi hasil observasi, hasil wawancara dan teknik validasi yang dilakukan oleh ahli materi dan ahli desain. Untuk mengetahui bahwa produk ini sesuai dan layak dengan melihat hasil analisis skor instrumen validasi ahli. Dari data uji validasi ahli, mendapatkan skor persentase 82,14% dari ahli materi, untuk kesesuaian konsep kebutuhan dasar dan komunikasi sosial pada model sistem isyarat kunci komunikasi sosial dan skor 85,71 dari ahli desain yakni, kesesuaian desain model sistem isyarat kunci komunikasi sosial isyarat kunci untuk diimpelemntasikan dalam menemukan isyarat kunci anak MDVI. Hasil penelitian menunjukkan bahwa temuan sistem isyarat kunci komunikasi sosial ini layak digunakan untuk menemukan cara anak MDVI dalam berkomunikasi khususnya dalam mengungkapkan kebutuhan dasar sehari-hari yang ditunjukkan dalam bentuk respon gestur, aktivitas, verbal dan campuran.
Kata Kunci : Isyarat Kunci, Komunikasi Sosial, Tunanetra MDVI
Pengembangan Buku Panduan Percakapan Bahasa Fungsional Pada Moda Transportasi Untuk Anak Disabiitas Rungu
Authors: Novialassafitri Sibi Dyah , Masitoh Siti , Purbaningrum Endang 
Published: October 2023

Penelitian ini bertujuan untuk menghasilkan produk berupa buku panduan serta mendeskripsikan kelayakan, kepraktisan Buku Panduan Percakapan Bahasa Fungsional Pada Moda Transportasi Untuk Anak Disabilitas Rungu. Penelitian ini menggunakan metode dengan pendekatan Research and Development ( R & D ) dengan mengadaptasi model 4D dari Thiagarajan 1974. Penelitian ini hanya sampai pada tahap development. Teknik analisis data menggunakan skala likert yang memiliki lima skor penilaian dan dirata-rata setiap butir pertanyaan. Uji validasi dilakukan oleh ahli materi dan ahli media. Dari data uji validasi ahli, mendapatkan skor persentase 78% dari ahli materi dan 98% dari ahli media.Sedangkan uji kepraktisan oleh ahli praktisi (guru kelas V) memperoleh 88% berada pada kategori baik. Kemudian, rata-rata hasil uji kepraktisan peningkatan pemahaman 6 siswa disabilitas rungu setelah diberikan buku panduan dan mempraktikannya memperoleh 90%.Hal ini menunjukkan bahwa buku panduan praktis dan untuk meningkatkan kemampuan berkomunikasi siswa disabilitas rungu tentang moda transportasi. Dari hasil tersebut, dapat disimpulkan bahwa buku Panduan Percakapan Bahasa Fungsional Pada Moda Transportasi Untuk Anak Disabilitas Rungu praktis dan layak digunakan untuk pembelajaran siswa disabilitas rungu.Kata Kunci: percakapan bahasa fungsional, disabilitas rungu, buku panduan, transportasi
Pengembangan Panduan Parenting Self Care Untuk Anak Autistic Spectrum Disorder Berbasis Aplikasi Mobile Learning
Authors: Ash Siddieqy Nur Ramadhani , Sujarwanto Sujarwanto , Widajati Wiwik 
Published: October 2023

Panduan self care untuk anak autistic spectrum disorder berbasis aplikasi mobile learning sebagai sarana pengembangan panduan self care untuk anak autistic spectrum disorder. Penelitian ini bertujuan untuk mengembangkan spesifikasi Produk panduan self care untuk anak autistic spectrum disorder berbasis aplikasi mobile learning dengan : (1) menguji kevalidan atau kelayakan produk panduan self care untuk anak autistic spectrum disorder berbasis aplikasi mobile learning, (2) dan kepraktisan produk panduan parenting self care untuk anak autistic spectrum disorder berbasis aplikasi mobile learning. Dalam penelitian ini, bila ditinjau dari tahapan penelitian menggunakan metode penelitian Research and Development (R & D) dengan mengadaptasi model 4D yaitu define, desighn, develop, dan disseminate. Penelitian ini menggunakan tiga tahapan define, design, dan develop. dengan teknik pengumpulan data dengan kuisioner, dan teknik analisis data menggunakan penghitungan skor rata-rata. Uji validasi dilakukan oleh ahli media dan ahli materi. Uji validitas ahli media menyimpulkan bahwa produk memperoleh 100% berada pada kategori sangat layak. Sedangkan, uji validitas materi memperoleh 88% berada pada kategori sangat layak. Hasil uji kepraktisan dari 4 responden mendapatkan hasil rata-rata 87% sehingga dapat disimpulkan bahwa pengembangan panduan self care untuk anak autistic spectrum disorder berbasis aplikasi mobile learning layak dan mudah digunakan oleh orang tua.
Katakunci: self care, mobile learning, autistic spectrum disorder
Optimization of the Extrusion Process in the Production of Compound Feeds for Dairy Cows
Authors: Kassymbek Rabiga , Iztayev Auyelbek , Balevi Tahir , Chomanov Urishbay , Zhumaliyeva Gulzhan , Shoman Assiya 
Published: October 2023

The paper proposes a way of enriching the composition of mixed fodder by combining two promising technologies with known effects: inclusion of germinated grain in the composition and extrusion. Crude and digestible protein, fiber, fat, and mineral elements Ca, K, Na, and P were studied. Inclusion of sprouted grain into mixed fodder and subsequent extrusion contribute to improvements in taste qualities, increased edibility, and assimilation of mixed fodder, as well as nutritive value. Taking into account the obtained knowledge about the influence of temperature regime and content of germinated triticale grain in mixed fodder production, it is advisable to continue research to adapt the technology and develop formulations for different types of animals and farm birds. The purpose of the study was to optimize the process of extrusion of sprouted triticale grain in order to reduce energy consumption and obtain high-quality extrudates. To achieve this goal, the following tasks were set: to analyze the regime factors affecting the fat content based on the optimization of technological modes of extrusion. To optimize the technology of extrusion of triticale grain of the Kozha variety, the fat content was chosen as the target function. Optimization of the technology of extrusion of triticale grain of the Kozha variety was carried out by the method of nonlinear programming. The following optimal technological modes of grain extrusion were obtained: The content of sprouted triticale grain is 15%, and the extrusion temperature is 140°C. With these optimal grain processing modes, the target function was 1.12%. The practical significance of the technology of the production of compound feeds with the use of extrusion in order to improve the quality and increase the shelf life. Doi: 10.28991/ESJ-2023-07-05-08 Full Text: PDF
Formation of contractility of the left ventricle in prematurely born children treated in neonatal intensive care and intensive care units, pathology of newborns
Authors: Kolosova M. V. , Pavlyukova E. N. , Neklyudova G. V. , Alekseeva E. O. , Lihomanov K. S. , Karpov R. S. 
Published: October 2023

Aim: To study contractility of the left ventricle (LV) in prematurely born children of early and preschool age who received treatment in intensive care units, neonatal intensive care units and pathology of newborns in the neonatal period.Material and Methods. The study included 155 children, of which 108 children aged from one to five years old, born with very low body weight and extremely low body weight; and 47 children of the same age, born full-term and healthy. Study design: pilot, cross-sectional, retrospective, case-control study. EchoCG was performed using the Vivid E9 ultrasound system (GE, Healthcare) with M5S matrix probe (1.5–4.6 MHz). The LV global circumferential (GCSMV, GCSPM, GCSApex), and longitudinal strain, as well as the global strain of the endocardial, middle and epicardial layers of the LV were assessed. in the systole “clockwise”) was found in 33.33% of children with a history of bronchopulmonary dysplasia, and in 28.13% of children who received mechanical ventilation during the neonatal period. In 25 (69.44%) of 36 children with signs of anemia in the neonatal period, there was a decrease in deformation along the circumference of the LV epicardial layer. In 13 (86.67%) of 15 clinical observations with signs of transient hypothyroidism in the anamnesis, a decrease in deformation along the circumference of the epicardial layer was revealed.Conclusion. Factors “body weight at birth”, “fetal growth retardation”, “anemia, use of mechanical ventilation in the neonatal period”, “transient hypothyroidism”, “development of bronchopulmonary dysplasia” in children of early and preschool age born prematurely with very low and extremely low body weight, adversely affect the formation of LV contractility and rotational mechanics in the postnatal period, exacerbating the disorders caused by the immaturity of the child’s heart tissue and the implementation of other pathogenetic mechanisms in prematurity, which requires medical supervision of this clinical group in polyclinic conditions.
Parameters of left ventricular deformation in elderly and senile patients with aortic stenosis after transcatheter implantation of the aortic valve
Authors: Matveeva M. G. , Ter-Akopyan A. V. , Alekhin M. N. 
Published: October 2023

Aim: To evaluate the parameters of left ventricle (LV) myocardial deformation (longitudinal, circular and radial) in patients with symptomatic severe aortic stenosis (AS) with preserved LV ejection fraction after transcatheter aortic implantation valve (TAVI) in the early postoperative period.Material and Methods. The study included 31 patients after TAVI out of 69 with symptomatic severe AS. Echocardiography (EchoCG) using two-dimensional speckle tracking technology was performed before TAVI and in the early postoperative period (within 5 ± 1,7 days).Results. There were no significant differences in the analysis of deformation parameters before TAVI and in the early postoperative period. There was a tendency to increase the longitudinal deformation of the LV, including the longitudinal deformation of the basal, middle and apical segments in individual patients. The longitudinal deformation of the left atrium did not change after TAVI.Conclusion. There were no significant changes in deformation parameters in elderly and senile patients with severe AS and preserved LV ejection fraction and with reduced LV deformation (longitudinal, circular and radial) after minimally invasive TAVI in the early postoperative period. There is a tendency to increase the global longitudinal deformation of the LV.
Quantitative characteristics of cardiomyopathy phenotypes in children and adults by the value of deviation from the norm of echocardiographic parameters
Authors: Sokolov A. A. , Smorgon A. V. , Kozhanov R. M. , Krivoshchekov E. V. 
Published: October 2023

The widespread use of the term “cardiomyopathy” in modern cardiology dictates the need to systematize and concretize the use of this term. Based on the approximation of changes in the function, cavities and thickness of the walls of the chambers to known dilated, hypertrophic and restrictive cardiomyopathy, imaging methods in cardiology have made it possible to combine many pathological changes in the chambers of the heart into certain sets of visual perception and to form the concepts of phenotypes and phenotypes of most heart diseases.Aim: To develop quantitative criteria for phenotypic changes in the left ventricle (LV), which can be used to control the dynamics of the disease and evaluate the effectiveness of treatment based on the results of a retrospective analysis of a large volume of digital data of echocardiographic studies in patients with myocardial diseases and healthy individuals.Material and Methods. A retrospective analysis of echocardiography protocols for the period 2009–2021 was performed in 13023 healthy individuals aged 2 days to 59 years and 317 patients with various heart diseases: hypertrophic, dilated and restrictive cardiomyopathies, and LV non-compaction myocardium aged 4 days to 60 years.Results. Criteria have been developed and proposed for the quantitative assessment by Z-index of pathological phenotypes of the left ventricle, which have a high (more than 95%) negative specificity in healthy individuals of any age and a positive one in patients with cardiomyopathies. The ability to quantify the dynamics of the course of diseases occurring with manifestations of restriction, dilation and LV hypertrophy was shown.