bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Genetic profiling of small intestine metastasis from poorly differentiated non-small cell lung cancer: report of 2 cases and literature review of the past 5 years
Authors: Wang Mengqin , Chen Gang , Luo Jiang , Fan Zhipeng , Liu Yuying , Xie Conghua , Gong Yan 
Published: November 2023

BackgroundPoorly differentiated non-small cell lung cancer (NSCLC) is characteristic of high rate of distant metastasis and late stages at diagnosis. Small intestine metastasis is a rare but severe complication of lung cancer with a high rate of mortality. However, there is currently a lack of genetic profile studies on the small intestine metastasis of lung cancer.Case presentationsWe present 2 cases of male patients in their 60s with primary NSCLC of low differentiation, initially with no distant metastasis detected. Biopsy samples were obtained from the primary pulmonary lesions, and both patients received systematic radiotherapy (RT) and chemotherapy. However, both cases presented with abdominal pain and distension, and immunohistochemistry of small intestine biopsy samples obtained by endoscopy confirmed lung cancer metastasis. Next generation sequencing was used to explore the genetic profiles from the biopsy samples of both the primary pulmonary lesions and small intestine metastases. The correlated genes responsible for the small intestine metastasis from poorly differentiated NSCLC in these 2 patients included TP53, LRP1B, and FGFR2. The reports of small intestine metastasis from poorly differentiated NSCLC with the past 5 years were systematically reviewed and summarized subsequently.ConclusionsPoorly differentiated NSCLC with small intestine metastases, while rare, substantially impacts the prognosis and poses major challenges for diagnosis and treatment. Through comparisons of genetic profiles between patients and in the same patient before and after metastasis, we identified the mutations in genes such as TP53, LRP1B, and FGFR2, which were correlated with the occurrence and progression of poorly differentiated NSCLC, as well as its small intestinal metastasis. This discovery has the potential to guide clinicians in developing personalized treatment plans through the manipulation of targeted and radiation therapies.
Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer
Authors: Cai Hao , Li Jiancheng , Chen Yu , Zhang Qiao , Liu Yang , Jia Houjun 
Published: November 2023

BackgroundColorectal cancer (CRC) remains a major global health concern, with significant morbidity and mortality rates. In this study, we aimed to develop a comprehensive blood indicator based on systemic inflammation and nutritional condition to predict the prognosis of resectable CRC patients.MethodsA retrospective cohort of 210 CRC patients who underwent radical resection at the First Affiliated Hospital of Chongqing Medical University, China, between January 2015 and December 2017, was included in the analysis. Baseline characteristics, preoperative blood markers, including neutrophil count, monocyte count, lymphocyte count, platelets, albumin, and CEA were retrospectively reviewed. Various blood indicators, such as NLR, PLR, MLR, SIRI and OPNI were calculated. The least absolute shrinkage and selection operator (LASSO) method was employed to select indicators to establish a novel comprehensive biomarker (named PSI). Kaplan-Meier survival curves and log-rank tests were used to evaluate the prognostic impact of preoperative OPNI, SIRI, and PSI. Univariate and multivariate Cox regression model were conducted to identify independent prognostic factors for CRC. The receiver operating characteristic (ROC) method assessed the predictive ability of PSI, stage, OPNI, and SIRI.ResultsPatients with higher preoperative OPNI and lower SIRI values had significantly better overall survival (OS). PSI was identified as an independent prognostic factor for OS in both univariate and multivariate analysis. Patients with medium (28.3-43.4) and high (&gt;43.4) PSI scores exhibited superior OS compared to those with low (≤ 28.3) PSI scores. PSI showed higher predictive ability (AUC: 0.734) than individual indicators alone (OPNI: 0.721, SIRI: 0.645, stage: 0.635).ConclusionThe novel indicator, PSI, based on preoperative SIRI and OPNI, demonstrated significant prognostic value for resectable CRC patients. PSI outperformed individual indicators and could serve as a reliable tool for prognostic evaluation in CRC patients.
The repercussions of digital bullying on social media users
Authors: Al-Turif Ghada A. R. , Al-Sanad Hessa A. R. 
Published: November 2023

ObjectiveThis study aims to examine the repercussions of digital bullying on social media users, especially among university students in Saudi Arabia.MethodsIt adopts a descriptive approach based on a social survey method with a sample of 640 male and female students from selected universities. A questionnaire was used to collect the data and to measure the repercussions of digital bullying on the victims, their families, and the society.ResultsThe findings reveal that most of the respondents agree that digital bullying has negative consequences for all the stakeholders involved. The results also indicate that female students are more aware of the repercussions of digital bullying than male students.ConclusionThe study recommends enhancing public awareness through organizing conferences, seminars, and workshops on the issue of digital bullying, and implementing and enforcing strict laws and penalties to punish the perpetrators and to prevent and reduce the harms of digital bullying.
Research into the relationship between digital health literacy and healthy lifestyle behaviors: an intergenerational comparison
Authors: Çetin Murat , Gümüş Rojan 
Published: November 2023

IntroductionDigital health literacy wields a pivotal role in individuals’ health status in terms of seeking and choosing appropriate and accurate information, and useful services from a vast array of choices. This study is aimed at assessing the validity and reliability of the Turkish version of Digital Health Literacy Instrument (DHLI) and examining the relationship between DHL and the healthy lifestyle behaviors of participants from X, Y, and Z generations.MethodsIn this study, to conduct a cross-sectional web-based survey, an online self-report questionnaire was built, and a convenience sample with a snowball approach was used. The study was conducted among 1,274 respondents aged between 18 and 64 years. Data collection tools consisted of the Personal Information Form, Lifestyle Behavior Scale II (HLBS II), and DHLI. Cultural validation and psychometric testing of DHLI, exploratory factor analysis, confirmatory factor analysis, Cronbach’s alpha test, and bivariate and multivariate regression analysis were used for statistical analysis.ResultsIn the study, the Turkish version of the DHLI tool consisting of six dimensions proved to be valid and reliable, and deemed appropriate for use across all age groups. The average digital health literacy of the respondents was sufficient, but the mean of healthy lifestyle behavior scores was moderate. There was a positive significant relationship between the total mean scores of DHLI and HLBS. Among the subdimensions of DHLI, while the highest mean scores were in DHLI Reliability, DHLI Privacy, and DHLI Search, DHLI Navigation and DHLI Relevance showed the lowest mean scores. DHLI Reliability, DHLI Relevance, and DHLI Adding Content were statistically significant predictors of health-related behaviors of the respondents.ConclusionThe most important feature and novelty of this study is that, although the DHLI scale has been widely translated for use in many countries, it has been translated and adapted to Turkish for the first time herein. The study offers crucial evidence about Generation X, Y, and Z’s DHL level and its positive relationships with health-related behaviors. Therefore, the community and its partners should lead the way in empowering individuals to understand and use online information in an effective, secure, and health-promoting manner, along with governments.
Impact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation
Authors: Laboux Timothée , Lenain Rémi , Visentin Jonathan , Flahaut Gauthier , Chamley Paul , Provôt François , Top Isabelle , Kerleau Clarisse , Labalette Myriam , Choukroun Gabriel , Couzi Lionel , Blancho Gilles , Hazzan Marc , Maanaoui Mehdi 
Published: November 2023

Given the risk of rejection, the presence of preformed donor specific antibodies (DSA) contraindicates transplantation in most allocation systems. However, HLA-Cw and -DP DSA escape this censorship. We performed a multicentric observational study, in which the objective was to determinate risk factors of acute antibody-mediated rejection (aABMR) in recipients transplanted with preformed isolated Cw- or DP-DSA. Between 2010 and 2019, 183 patients were transplanted with a preformed isolated Cw- or DP-DSA (92 Cw-DSA; 91 DP-DSA). At 2 years, the incidence of aABMR was 12% in the Cw-DSA group, versus 28% in the DP-DSA group. Using multivariable Cox regression model, the presence of a preformed DP-DSA was associated with an increased risk of aABMR (HR = 2.32 [1.21–4.45 (p = 0.001)]) compared with Cw-DSA. We also observed a significant association between the DSA’s MFI on the day of transplant and the risk of aABMR (HR = 1.09 [1.08–1.18], p = 0.032), whatever the DSA was. Interaction term analysis found an increased risk of aABMR in the DP-DSA group compared with Cw-DSA, but only for MFI below 3,000. These results may plead for taking these antibodies into account in the allocation algorithms, in the same way as other DSA.
New Application of cycloSaligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria
Authors: Munier Mathilde , Tritsch Denis , Lièvremont Didier , Rohmer Michel , Grosdemange-Billiard Catherine 
Published: November 2023

In this work, we implemented for the first time the cycloSaligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria. Here, we report the synthesis of 34 cycloSaligenyl prodrugs of fosfoxacin and its derivatives. Among them, fifteen double prodrugs efficiently prevented the growth of the non-pathogenic, fast-growing Mycobacterium smegmatis.
Experimental Evaluation of Chemical Reactions Involved in Ultrasonic-Assisted Absorption of Bulk CO2
Authors: Shokrollahi Fatemeh , Lau Kok Keong , Partoon Behzad 
Published: November 2023

As the most mature natural gas sweetening process, absorption has always been improved to meet the separation requirement. Recently, ultrasonic irradiation has been proposed as a technique that can intensify CO2 absorption. However, further studies are still required, particularly focusing on the sonochemical effect. Since the influence of the sonochemical effect on the reaction pathway is still debatable, attention must be given to verifying the influence of ultrasonic irradiation on the chemical reactions of CO2 absorption. Hence, this work aims to evaluate the influence of OH˙ radicals generated by the sonochemical effect on the chemical reactions involved during CO2 absorption using promoter-free methyldiethanolamine (MDEA). For the evaluation, various samples under irradiated and non-irradiated conditions are analyzed using the HPLC characterization technique. The results show that the hypothesis of changing the reaction pathway due to the presence of the sonochemical effect is invalid. However, it can accelerate the generation of hydroxyl radicals (OH˙) via water sonolysis. Thus, the origin of sonochemistry in aqueous solutions is defined as water sonolysis. The analysis of the CO2 absorption rate also demonstrates the presence of accelerated chemical reactions (contributed by the OH˙ radicals), which could potentially make the slow kinetic MDEA more practical for industrial application.
MANEJO E PERFIL DE CÃES ATENDIDOS NA SUPERINTENDÊNCIA UNIDADE HOSPITALAR VETERINÁRIA DA UNIVERSIDADE FEDERAL DA FRONTEIRA SUL E SUAS IMPLICAÇÕES NO BEM-ESTAR ANIMAL
Authors: De Jesus Leticia Viviane , Cervo Luciana Velasques , Taveira Layane Lina Maia , Camilotti Laura Antonia , Wagner Tainá Caroline Leite , Rocha Tais dos Santos , Laux Raissa Lopes , Prates Izadora Fernanda Gomes , Benvegnú Dalila  Moter 
Published: November 2023

O bem-estar animal normalmente pode ser mensurado por três abordagens distintas, no qual a primeira envolve as funções biológicas e fisiológicas, a segunda abrange questões neuropsicológicas, e a terceira a manifestação dos comportamentos naturais. Neste contexto o objetivo deste estudo foi identificar a qualidade de vida de 249 cães atendidos na Superintendência Unidade Hospitalar Veterinária da Universidade Federal da Fronteira Sul (SUHVU) – Campus Realeza/PR. Para tal, foi realizado coletas de dados retrospectivos no período de janeiro de 2020 à julho de 2021, no qual, foram obtidos os seguintes resultados: 72,3% dos cães eram domiciliados, 14,1% eram domiciliados e estavam sob responsabilidade de tutor em situação de vulnerabilidade social, no qual se encontravam cadastrados no Cadastro Único e 13,7% eram cães errantes. Em relação a fertilidade, 73,1% não eram castrados e 26,9% eram castrados. Com relação ao sexo 60,4% dos cães eram fêmeas e 39,6% eram machos. No que se refere a alimentação 52,9% eram alimentados por comida e ração, 36,6% somente ração e 10,5% apenas comida. Acerca do comportamento, 79,9% eram dóceis, 10,4% agressivos, 5,2% medrosos e 4,4% inquietos. A respeito da vacinação 75,6% dos animais receberam algum tipo de vacina, enquanto que 24,4% nunca foram vacinados. No entanto, somente 38,5% dos cães que foram vacinados alguma vez, receberam a vacina contra a raiva. No que diz respeito a vermifugação, 66,4% estavam atualizados, 19,8% desatualizados e 13,8% nunca receberam vermífugo. Quanto ao acesso à rua, 60,2% possuíam acesso com a presença ou ausência do tutor, ou mesmo acesso livre em se tratando de cães errantes e 39,8% não possuíam acesso. Em relação à presença de ectoparasitas 55,8% não apresentavam e 44,2% apresentavam. Além disso, foram analisadas alterações hematológicas e parâmetros bioquímicos, sendo que 48,8% dos animais apresentaram alteração no hemograma, sendo 18,4% identificados com anemia, apresentando também hematócrito inferior, valores de proteínas plasmáticas e albumina diminuídos e valores de ureia e creatinina aumentados. Em relação, a mobilidade obtivemos prevalência de 95% de cães vivendo de forma solta no ambiente que são mantidos, em contrapartida 5% dos cães sendo mantidos presos. Assim, espera-se que estes dados contribuam para o direcionamento de ações para promoção da saúde e do bem-estar animal no município de Realeza – PR.
مفهوم البيانات الضخمة في مهنة التمريض
Authors: جرادات رائـــد علي 
Published: November 2023

المقدمة: تعتبر البيانات الضخمة مفهومًا مهمًا لتخصصات الرعاية ، مثل التمريض والطب ، وقد أتاح التطور السريع للتكنولوجيا كميات هائلة من البيانات المتاحة وقابلة للتحقيق في أي وقت وفي أي مكان حول العالم. وليس هناك تعريف محدد لهذا المفهوم في التمريض والهدف من هذه الدراسة تحديد المعنى لمفهوم البيانات الضخمة في مجال التمريض
الطريقة: تم استخدام معايير مورس وزملائة نضج المفاهيم كإطار عمل. تم إجراء مراجعة الأدبيات لمفهوم البيانات الضخمة لتقييم المبادئ المنطقية والمعرفية واللغوية والبراغماتية. تم استرداد أدبيات البيانات الضخمة من خلال البحث في الفهرس التراكمي للتمريض والأدب الصحي المساعد (CINAHL) و MEDLINE و PubMed و Google Scholar. كانت مصطلحات البحث المستخدمة هي البيانات الضخمة، وتحليل البيانات الضخمة، والبيانات الضخمة والتمريض، وعلوم البيانات. وخلصت الدراسة الى انه اصبحت البيانات الضخمة مؤخرًا مصطلحًا شائعًا بين الباحثين ومتخصصي تكنولوجيا المعلومات وكذلك المتخصصين في مجال الصحة. على الرغم من أن معنى المفهوم لا يزال غير واض، إلا أنه يحمل وعودًا كبيرة لتحسين جودة الرعاية الصحية. على الرغم من أن مفهوم البيانات الضخمة قد جذب انتباه العلماء في تخصص التمريض، إلا أن عدم وجود تعريف موحد للمفهوم يحد من استخدام البيانات الضخمة في أبحاث التمريض. مع كل تعقيداته، أصبح المفهوم أكثر انتشارًا بشكل متزايد، ويؤثر على طريقة تعلم العاملين في مجال التمريض وممارستها وإجراء البحوث وتطوير السياسة. ويمكن أن يساعد تحديد المفهوم بطريقة متسقة على تشخيص وعلاج المشكلات المتعلقة بالصحة وتعزيز جودة الرعاية الصحية
Exploring the effect of interface properties between CeO
x
electron transport layer and MAPbI3 perovskite layer on solar cell performances through numerical simulation
Authors: Haque Md. Mahfuzul , Mahjabin Samiya , Rashid M. J. , Alharbi Hamad F. , Suemasu Takashi , Akhtaruzzaman Md. 
Published: November 2023

Abstract
Organo-metal halide perovskite solar cells (PSCs) have received a lot of attention to the photovoltaic research community, mainly due to the rapid development of their cell performances. But industry-level production of PSCs is hindered for several reasons. At present, the use of high-temperature processed electron transport layer (ETL) such as TIO2, the use of chemically unstable ETL such as ZnO and SnO2, etc. are ETL-related obstacles behind this industrialization. Aiming to remove these problems, cerium oxide (CeO
x
), one of the most Earth-rich metal oxides has been chosen as ETL for this study. In this study, the SCAPS-1D simulation package has been used for an intensive study on ETL/PSK interface for a methylammonium lead iodide (MAPbI3)-based PSC having CeO
x
as ETL. From this simulation, the effect of conduction band offset (CBO) between CeO
x
and MAPbI3 has been found as the key player behind the cell performances. Defects at this interface have also been introduced and varied for studying their effects on cell performance at different CBO values. The temperature stability of a PSC is another important issue that has been considered in this study to find the effect of operating temperature on the PSC. This study would enlighten the researchers in implying some fantastic techniques at the ETL/PSK interface for improving the cell performance that will forward the research community a few steps to use CeO
x
as a promising ETL in PSC.
ANALISA PEMERATAAN SUMBER DAYA TENAGA KERJA PADA PROYEK PRESERVASI JALAN WARU-SIDOARJO-KRIAN
Authors: Indiarto Gigih Ghilang Indiarto 
Published: November 2023

Proyek konstruksi adalah serangkaian kegiatan yang membutuhkan waktu, uang, dan sumber daya. Sumber daya berupa manusia, alat dan bahan. Jika sumber daya ini digunakan, jika pengalokasiannya tidak diatur, maka penggunaan sumber daya tersebut sangat tidak efisien, sehingga menurunkan jalur kritis dari jaringan yang dihasilkan. Pengalokasian sumber daya dilakukan dengan harapan penggunaan sumber daya tenaga kerja akan merata dan tidak terlalu banyak sumber daya tenaga kerja yang diinvestasikan. Metode alokasi sumber daya dapat mengurangi fluktuasi masukan tenaga kerja dalam proyek. Dalam penelitian ini digunakan pendekatan kuantitatif. Pendekatan kuantitatif merupakan jenis penelitian yang dilakukan secara terstruktur, terencana, dan sistematis sejak awal hingga pembuatan desain penelitiannya. Dari hasil pemerataan tenaga kerja tukang yang telah dilakukan, menghasilkan penggunaan tenaga kerja memiliki grafik yang ideal. Sehingga, terdapat perbedaan kebutuhan tenaga kerja dan durasi sebelum dan sesudah levelling, yaitu : Sebelum levelling : durasi 243 hari jumlah tenaga kerja puncak sebanyak 100 tukang dan yang paling sedikit 31 tukang. Sesudah levelling : durasi 310 hari dengan puncak jumlah tenaga kerja sebanyak 100 tukang dan paling sedikit 40 tukang. Selisih durasi proyek setelah dan sebelum dilakukan pemerataan tenaga kerja adalah 70 hari.
Kata Kunci : resource leveling, alokasi tenaga kerja, proyek konstruksi
KAJI TERAP PENGKAYAAN PAKAN INDUK IKAN BANDENG Chanos chanos Forsskall UNTUK MENINGKATKAN PERFORMA HASIL PEMBENIHAN
Authors: Iskandar Andri , Carman Odang , AM NM Fatih Asror , Ruliaty Lisa 
Published: November 2023

Ikan bandeng Chanos chanos Forsskall, adalah salah satu jenis ikan yang banyak dibudidayakan di Asia Tenggara, termasuk Indonesia. Budidaya ikan bandeng di Indonesia menunjukkan performa peningkatan produksi yang sangat baik dari tahun ke tahun. Pada tahun 2012 produksi ikan bandeng ukuran konsumsi mencapai 482.930 ton dan pada tahun 2017 mencapai angka 637.845 ton dengan tingkat konsumsi rata-rata masyarakat terhadap ikan bandeng adalah 1.9 kg/kapita. Peningkatan permintaan dan produksi bandeng berdampak terhadap peningkatan produksi benih secara signifikan dan merubah pola budidaya di Indonesia menjadi sistem semi-intensif maupun intensif. Penggunaan pakan komersil dengan kualitas dan kuantitas yang baik sangat diperlukan, salah satunya adalah dengan pengkayaan unsur nutrisi pakan yang bertujuan untuk meningkatkan kualitas hasil reproduksi induk ikan bandeng sehingga menghasilkan persentase jumlah telur dan benih yang meningkat secara signifikan. Studi ini bertujuan untuk mempelajari dan melakukan kaji terap teknis pembenihan ikan bandeng dengan pemanfaatan bahan-bahan nutrisi tambahan, sehingga dapat dijadikan sumber referensi bagi para pembudifaya untuk dapat meningkatkan performa usaha budidayanya. Hasil studi menunjukkan bahwa fertilization rate rata-rata induk ikan bandeng yang diberikan pakan yang diperkaya berkisar antara 82 - 98%, dengan persentase hatching rate tertinggi yaitu 95% dan terendah 80%. Selama stadia larva sampai mencapai umur 10 hari pemeliharaan, diberikan pakan jenis Rotifera sp., selanjutnya diberikan pakan komersil. Sampai akhir pemeliharaan, rata-rata survival rate benih berkisar antara 85 – 90%. Hasil kaji terap mengindikasikan bahwa pengkayaan pakan yang diberikan terhadap induk, dapat meningkatkan protein pakan sehingga memicu pemijahan induk ikan bandeng. Hal ini berdampak terhadap dihasilkannya benih dengan kualitas yang baik.
POTENCY OF ENHALUS ACOROIDES FROM INDONESIA REGION FOR HALAL PHARMACEUTICAL INDUSTRY
Authors: Ismarti Ismarti , Amelia Fitrah 
Published: November 2023

Currently, the implementation of the Halal assurance system in Indonesia is mandatory. A side from food, pharmaceutical, cosmetics, and medicines must all be halal certified. Natural products, particularly marine-based products, are an alternative choice for the cosmetics and pharmaceutical industry's raw materials. Enhalus acoroides are common along Indonesia's coasts and have the potential to be used as raw materials in halal cosmetics and pharmaceutical products. The purpose of this paper is to examine the potential of E. acoroides samples collected from various locations in Indonesia in terms of bioactive compounds and their applications. Secondary metabolites namely alkaloids, flavonoids, polyphenols, steroids, triterpenes, and tannins have been reported in E. acoroides extract from Indonesia, and they have the potential to be used as antibacterial, antiaging, antiviral, antitumor, and antioxidant in the pharmaceutical and cosmetic industries in Indonesia