bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninvasive Evaluation of Breast Tumor Response to Combined Ultrasound‐Stimulated Microbubbles and Hyperthermia Therapy Using Quantitative Ultrasound‐Based Texture Analysis Method
Authors: Sharma Deepa , Sannachi Lakshmanan , Osapoetra Laurentius Oscar , Cartar Holliday , Cui Wentao , Giles Anoja , Czarnota Gregory J. 
Published: October 2023

ObjectivesQuantitative ultrasound (QUS) is a noninvasive imaging technique that can be used for assessing response to anticancer treatment. In the present study, tumor cell death response to the ultrasound‐stimulated microbubbles (USMB) and hyperthermia (HT) treatment was monitored in vivo using QUS.MethodsHuman breast cancer cell lines (MDA‐MB‐231) were grown in mice and were treated with HT (10, 30, 50, and 60 minutes) alone, or in combination with USMB. Treatment effects were examined using QUS with a center frequency of 25 MHz (bandwidth range: 16 to 32 MHz). Backscattered radiofrequency (RF) data were acquired from tumors subjected to treatment. Ultrasound parameters such as average acoustic concentration (AAC) and average scatterer diameter (ASD), were estimated 24 hours prior and posttreatment. Additionally, texture features: contrast (CON), correlation (COR), energy (ENE), and homogeneity (HOM) were extracted from QUS parametric maps. All estimated parameters were compared with histopathological findings.ResultsThe findings of our study demonstrated a significant increase in QUS parameters in both treatment conditions: HT alone (starting from 30 minutes of heat exposure) and combined treatment of HT plus USMB finally reaching a maximum at 50 minutes of heat exposure. Increase in AAC for 50 minutes HT alone and USMB +50 minutes was found to be 5.19 ± 0.417% and 5.91 ± 1.11%, respectively, compared to the control group with AAC value of 1.00 ± 0.44%. Furthermore, between the treatment groups, ΔASD‐ENE values for USMB +30 minutes HT significantly reduced, depicting 0.00062 ± 0.00096% compared to 30 minutes HT only group, showing 0.0058 ± 0.0013%. Further, results obtained from the histological analysis indicated greater cell death and reduced nucleus size in both HT alone and HT combined with USMB.ConclusionThe texture‐based QUS parameters indicated a correlation with microstructural changes obtained from histological data. This work demonstrated the use of QUS to detect HT treatment effects in breast cancer tumors in vivo.
Relationship among low baseline muscle mass, skeletal muscle quality, and mortality in critically ill children
Authors: Xue Yang , Wang Tian‐Tian , Zhang Lei , Zheng Shuang , Mu Yue‐Ming , Jia Fei‐Yong , Du Lin 
Published: October 2023

AbstractBackgroundStudies in adults have shown that low baseline muscle mass at intensive care unit (ICU) admission was associated with poor clinical outcomes. However, no information on the relationship between baseline muscle quality or mass and clinical outcomes in critically ill children was found.Methods3775 children were admitted to the pediatric ICU (PICU), 262 were eligible for inclusion. Abdominal computed tomography was performed to assess baseline skeletal muscle mass and quality. Patients were categorized to normal or low group based on the cutoff value for predicting hospital mortality of the skeletal muscle index (SMI; 30.96 cm2/m2) and skeletal muscle density (SMD; 41.21 Hounsfield units).ResultsBody mass index (BMI) (18.07 ± 4.44 vs 15.99 ± 4.51) and BMI‐for‐age z score (0.46 [−0.66 to 1.74] vs −0.87 [−1.69 to 0.05]) were greater in the normal‐SMI group, the length of PICU stay was longer in the low‐SMI group (16.00 days [8.50–32.50] vs 13.00 days [7.50–20.00]), and the in‐PICU mortality rate in the normal‐SMI group (10.00%) was lower than the low‐SMI group (22.6%). Children with low SMD had a higher in‐PICU mortality rate (25.6% vs 7.7%), were younger (36.00 months [12.00–120.00] vs 84.00 months [47.50–147.50]) and weighed less (16.40 kg [10.93–37.25] vs 23.00 kg [16.00–45.00]). Mortality was greater in patients with lower SMD and prolonged hospital stay (log‐rank, P = 0.007). SMD was an independent predictor for length of PICU stay and in‐PICU mortality.ConclusionsLow baseline skeletal muscle quality in critically ill children is closely tied with a higher in‐PICU mortality and longer PICU stay and is an independent risk factor for unfavorable clinical outcomes.
Layoffs during a pandemic: Results from an experiment on the management practices of nonprofit organizations and business firms
Authors: Russell Allison R. , Frisone Michael , Frumkin Peter 
Published: October 2023

AbstractGiven the challenges of the COVID‐19 pandemic, both business and nonprofit organizations were forced to respond quickly with regard to organizational operations, resources, and workplace safety. The pandemic offers a unique context through which to examine how the public perceives organizational responses to unexpected crisis situations and whether they view them as socially responsible. Using a mixed experimental design, this study investigates the influence of organizational decision‐making during COVID‐19 on the public's perceptions of the organization. It also examines whether the type of organization—nonprofit or for‐profit—influences these perceptions and the willingness of participants to support the organization either by purchasing the product or donating to the organization.
Breaking the conformational ensemble barrier: Ensemble structure modeling challenges in CASP15
Authors: Kryshtafovych Andriy , Montelione Gaetano T. , Rigden Daniel J. , Mesdaghi Shahram , Karaca Ezgi , Moult John 
Published: October 2023

AbstractFor the first time, the 2022 CASP (Critical Assessment of Structure Prediction) community experiment included a section on computing multiple conformations for protein and RNA structures. There was full or partial success in reproducing the ensembles for four of the nine targets, an encouraging result. For protein structures, enhanced sampling with variations of the AlphaFold2 deep learning method was by far the most effective approach. One substantial conformational change caused by a single mutation across a complex interface was accurately reproduced. In two other assembly modeling cases, methods succeeded in sampling conformations near to the experimental ones even though environmental factors were not included in the calculations. An experimentally derived flexibility ensemble allowed a single accurate RNA structure model to be identified. Difficulties included how to handle sparse or low‐resolution experimental data and the current lack of effective methods for modeling RNA/protein complexes. However, these and other obstacles appear addressable.
Integrative species delimitation of the Selaginella sanguinolenta (Selaginellaceae) group with description of a new species, S. baodongii
Authors: Zhang Meng‐Hua , Zhang Xian‐Chun , Shalimov Alexander Petrovich , Shmakov Alexander Ivanovich , Xiang Qiao‐Ping 
Published: October 2023

AbstractSelaginella sanguinolenta group is widely distributed from the Himalayas to Siberia and the Russian Far East, including four to nine taxa. Despite progress in recent phylogenetic studies of the S. sanguinolenta group, the problem of species delimitation in this group remains. We revise the taxonomy of the S. sanguinolenta group based on an integrative approach considering morphological, molecular, and geographical evidence. The sampling for molecular analysis based on rbcL, psbA, and 26S nrDNA sequence data involved 71 individuals, covering the geographical range of this group. A total of 21 morphological traits from 103 specimens were explored using principal component analysis and linear discriminant analysis (LDA). The LDA results indicate that the combination of ventral leaf cilium length and ventral/dorsal leaf carinate characteristics enable a success rate of more than 90% in distinguishing between S. aitchisonii (western Himalayas to northern China), S. jacquemontii (western Himalayas to southwest China), and S. sanguinolenta (Russian Far East regions to northeast China). The phylogenetic analysis results of nuclear and plastid DNA markers further disclose the clear molecular differentiation. Selaginella nummularifolia, S. rossii, and S. sajanensis are well‐defined species based on morphological and molecular evidence with narrow distribution ranges respectively. Based on molecular and morphological evidence, in combination with distribution information, we finally recognize seven species in the S. sanguinolenta group, including a new species, S. baodongii sp. nov. from the bordering regions of Russia and China in northeast Asia.
Use of wind energy for desalination of seawater for irrigation
Authors: Tanji Rajaa , Boutaibi Youssef 
Published: October 2023

AbstractIn the context of the scarcity of water resources and the population growth that the world is experiencing, the only resource still available in inexhaustible quantities is seawater. The exploitation of this resource is possible only through the use of desalination techniques. The cost of energy was always the main constraint to water desalination; scientists had to develop new techniques to use renewable energies, in particular wind energy, to satisfy the high energy consumption of desalination plants. Morocco enjoys a privileged geographical location. In fact, Morocco is surrounded by two seas: the Atlantic Ocean and the Mediterranean. In terms of energy, Morocco has a large wind potential, especially in the south. In fact, according to the, Morocco is the fourth renewable energy producer in Africa with a capacity of 3061 MW. Within this framework, an ambitious project is currently being prepared by the Ministry of Agriculture, Maritime Fisheries, Rural Development and Water and Forests of Morocco, the construction of a desalination plant for irrigation and a 40‐MW wind farm in Dakhla, which will serve a new irrigated area in Dakhla of 5000 ha. This desalination station and sea intake will be located 75 km north of Dakhla and will have a capacity of 100,000 m3/d, 30 million cubic meters per year. It will use reverse osmosis technology to produce water that meets international standards for irrigation water quality. This megaproject will have a significant economic impact on the Dakhla‐Oued Eddahab region: first, the production of nearly 500,000 t of agricultural production for an added value of about 50 million USD per year and second, the creation of nearly 10,000 permanent jobs.
Introduction to Esports in the Asia-Pacific
Authors: Gilardi Filippo , Martin Paul 
Published: October 2023

AbstractThe introduction aims to provide an understanding of the status of the esports phenomenon in countries from the Asia-Pacific region. The chapter presents readers with the main objectives and topics of the book. It does this by reviewing extant research on esports, with a focus on outlining the main theoretical, industrial, and social concerns of esports practices. It then defines the gap this book aims to fill. The introduction finally describes the structure of the book, focusing on issues in specific local contexts as well as interconnections across the region.
Concircular Hypersurfaces and Concircular Helices in Space Forms
Authors: Lucas Pascual , Ortega-Yagües José Antonio 
Published: October 2023

AbstractIn this paper, we find a full description of concircular hypersurfaces in space forms as a special family of ruled hypersurfaces. We also characterize concircular helices in 3-dimensional space forms by means of a differential equation involving the concircular factor and their curvature and torsion, and we show that the concircular helices are precisely the geodesics of the concircular surfaces.
Hartogs-type theorems in real algebraic geometry, II
Authors: Bilski Marcin , Bochnak Jacek , Kucharz Wojciech 
Published: October 2023

AbstractLet $$f:X\rightarrow \mathbb {R}$$

f
:
X
→
R

be a function defined on a connected nonsingular real algebraic set X in $$\mathbb {R}^n$$

R

n

with $$\textrm{dim}X\ge 2.$$

dim
X
≥
2
.

We prove that f is a regular function whenever the restriction $$f|_C$$

f
|

C

is a regular function for every algebraic curve C in X that is an analytic submanifold homeomorphic to the unit circle and has at most one singular point. We also have a suitable version of this result for X not necessarily connected.
Case series and literature review of primary hyperoxaluria type 1 in Chinese patients
Authors: Wu Jiayu , Song Jing , He Yanzhao , Zhong Cheng , Yang Qin , Li Qiu , Wang Mo 
Published: October 2023

AbstractBased on the single-center case reports and all reported patients with primary hyperoxaluria type 1 (PH1) in China, this study discussed the clinical and genetic characteristics of this disease retrospectively. We reported and validated a novel genetic variation c.302 T > G: the clinical phenotypes of the two siblings were similar, in which both had onset in infancy, mainly manifested as renal insufficiency, and died within 6 months out of end-stage renal disease. The literature review is the first to summarize the Chinese patients with PH1 up to now. Forty-eight Chinese patients were included, containing 7 adults and 41 children. The median onset age was 51 months, and the ratio of male to female was 2.69:1. It showed a poor prognosis: 51.1% of Chinese primary hyperoxaluria type 1 patients suffered from end-stage renal disease, and 38.9% of patients died. Urolithiasis was the most common clinical manifestation both in adults and children, while infant-onset patients generally presented with renal insufficiency and had a higher mortality of 75.0%. One hundred and forty-nine AGXT mutant alleles are currently known in the Chinese population, c.33dupC and c.815_816insGA were the most common AGXT genes, accounting for 12.0% and 10.1% of allele frequencies, respectively. The exons 1, 2, 6, and 8 were the most common locations of gene variants, accounting for 78% of all variants, which will be promising targets of DNA sequencing for primary hyperoxaluria type 1.
Dual-band light-induced thermoelastic spectroscopy utilizing an antiresonant hollow-core fiber-based gas absorption cell
Authors: Bojęś Piotr , Jaworski Piotr , Pokryszka Piotr , Belardi Walter , Spagnolo Vincenzo , Krzempek Karol 
Published: October 2023

AbstractIn this paper, dual-band gas detection using a combination of the light-induced thermoelastic spectroscopy (LITES) and an antiresonant hollow-core fiber-based (ARHCF) gas absorption cell is demonstrated. The broad wavelength operation capability of a standard 32 kHz quartz tuning fork and the self-developed fiber-based gas absorption cell was exploited to demonstrate quasi-simultaneous detection of N2O and CO2, at 4570 nm (2188.2 cm−1) and 2006 nm (4985.9 cm−1), respectively. The signal analysis was based on the wavelength modulation spectroscopy technique, allowing to achieve a noise equivalent absorption coefficient (NEA) of 8.6 × 10–7 cm−1 and 1.7 × 10–6 cm−1 for N2O and CO2, respectively. The results indicate that the combination of ARHCFs with the LITES method is well suited for the design of broadband gas detectors and show remarkable potential in the fabrication of miniaturized, versatile and relatively inexpensive gas sensors operating over a wide spectral range, thus allowing multigas detection.
Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial
Authors: Vaccaro Maria Grazia , Innocenti Bernardo , Cione Erika , Gallelli Luca , De Sarro Giovambattista , Bonilla Diego A. , Cannataro Roberto 
Published: October 2023

Abstract
Background
Dietary nitrate (NO3−) has been shown to be useful as an ergogenic aid with potential applications in health and disease (e.g., blood pressure control). However, there is no consensus about the effects of dietary NO3− or beetroot (BR) juice supplementation on cognitive function.

Objective
The aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance.

Methods
A double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24 F; 20 M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg/m2) were randomly allocated to receive first either four BR-based chewable tablets (BR-CT) containing 3 g of a Beta vulgaris extract (RedNite®) or four tablets of a placebo (maltodextrin). A 4-day washout period was used before crossover. Ninety minutes after ingestion of the treatments, a neuropsychological testing battery was administered in each period. The trial was registered at clinicaltrials.gov NCT05509075.

Results
Significant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+ 20.69%) and delayed (+ 12.34%) recalls. Likewise, enhancement on both frontal lobe functions (+ 2.57%) and cognitive flexibility (+ 11.16%) were detected after BR-CT. There was no significant change (p < 0.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2.

Conclusions
The acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.
Relationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS)
Authors: Zhang Heli , Wang Jingpin , Zhang Siwei , Tong Sumei , Hu Jinping , Che Ying , Zhuo Lin , Wang Peng , Geng Rongmei , Zhou Yujie , Wang Panfeng , Zhan Siyan , Li Baohua 
Published: October 2023

Abstract
Background and purpose
Efforts to improve nurses’ physical and mental health are critical to ensuring the safety and quality of the healthcare system. Long-term studies targeting the relevancy of nurses’ occupation characteristics with health conditions remain insufficient. This study aimed to examine the relationship between nurses’ night shift and sleep problems and metabolic abnormalities risk.

Methods
This study was a part of the National Nurse Health Study, an ambispective cohort study in China, in 2021. Based on an integration physical examination data system, this study carried out a retrospective analysis of 730 nurses from 2018 to 2020 and combined with a questionnaire survey in 2021. The STROBE guidelines were adopted for reporting.

Results
In the 23 (23.0, 24.0) months follow-up, higher night shift load was associated with more sleep problems such as shortened sleep duration, sleep disorders, poor sleep quality, and sleep deprivation. Moreover, night shift load was associated with chronic diseases risk factors, increasing body mass index and body fat, with more night shift density, increasing the occurrence of low levels of high-density lipoprotein cholesterol, high triglyceride, triglyceride/high-density lipoprotein cholesterol ratio, and serum uric acid.

Conclusion
The night shift load has become an occupational health concern, contributing to chronic diseases relevant metabolic risk factors and negative influence on sleep health. Focus on the strategies to improve the sleep quality of nurses undergoing night shift work, optimize work scheduling and ongoing monitor the relevant risk factors are essential to enhance the stability and well-being of the nursing workforce.
Clinical Trials registration information: NCT04572347, on October 1, 2020. https://www.clinicaltrials.gov/ct2/show/NCT04572347
Percutaneous sacral screw fixation alone sufficient for mildly displaced U-type sacral fractures with preserved osseous fixation pathways
Authors: Saiz Augustine M. , Kellam Patrick J. , Amin Adeet , Arambula Zachary , Rashiwala Abhi , Gary Joshua L. , Warner Stephen J. , Routt Milton , Eastman Jonathan G. 
Published: October 2023

Abstract
Purpose
To describe U-type sacral fracture characteristics amenable to percutaneous sacral screw fixation.

Methods
U-type sacral fractures were identified from a trauma registry at a level 1 trauma center from 2014 to 2020. Patient demographics, injury mechanism, fracture characteristics, and fixation construct were retrospectively retrieved. Associations between fracture pattern and surgical fixation were identified.

Results
82 U-type sacral fractures were reviewed. Six treated with lumbopelvic fixation (LPF) and 76 were treated with percutaneous sacral screws (PSS) alone. Patients receiving LBF had greater sacral fracture displacement in coronal, sagittal, and axial planes compared to patients receiving PSS alone (P < 0.05), negating osseous fixation pathways. All patients went onto sacral union and there were no implant failures or unplanned reoperations for either group.

Conclusion
If osseous fixation pathways are present, U-type sacral fractures can be successfully treated with percutaneous sacral screws. LPF may be indicated in more displaced fractures with loss of spinopelvic alignment. Both techniques for U-type sacral fractures result in reliable fixation and healing without reoperations.
Identifying the best candidates for reduced port gastrectomy
Authors: Chung Jae Hun , Hwang Jawon , Park Sung Hyun , Kim Ki-Yoon , Cho Minah , Kim Yoo Min , Shin Hye Jung , Lee Si-Hak , Hwang Sun-Hwi , Hyung Woo Jin , Kim Hyoung-Il 
Published: October 2023

Abstract
Background
Previous studies have focused on the non-inferiority of RPG compared with conventional port gastrectomy (CPG); however, we assumed that some candidates might derive more significant benefit from RPG over CPG.

Methods
We retrospectively analyzed the clinicopathological and perioperative parameters of 1442 patients with gastric cancer treated by gastrectomy between 2009 and 2022. The C-reactive protein level on postoperative day 3 (CRPD3) was used as a surrogate parameter for surgical trauma. Patients were grouped according to the extent of gastrectomy [subtotal gastrectomy (STG) or total gastrectomy (TG)] and lymph node dissection (D1+ or D2). The degree of surgical trauma, bowel recovery, and hospital stay between RPG and CPG was compared among those patient groups.

Results
Of 1442 patients, 889, 354, 129, and 70 were grouped as STGD1+, STGD2, TGD1+, and TGD2, respectively. Compared with CPG, RPG significantly decreased CRPD3 only among patients in the STGD1+ group (CPG: n = 653, 84.49 mg/L, 95% CI 80.53–88.45 vs. RPG: n = 236, 70.01 mg/L, 95% CI 63.92–76.09, P < 0.001). In addition, the RPG method significantly shortens bowel recovery and hospital stay in the STGD1+ (P < 0.001 and P < 0.001), STGD2 (P < 0.001 and P < 0.001), and TGD1+ (P = 0.026 and P = 0.007), respectively. No difference was observed in the TGD2 group (P = 0.313 and P = 0.740).

Conclusions
The best candidates for RPG are patients who undergo STGD1+, followed by STGD2 and TG D1+, considering the reduction in CRPD3, bowel recovery, and hospital stay.