bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diet and Lifestyle Modifications for Fibromyalgia
Authors: Metyas Caroline , Aung Tun Tun , Cheung Jennifer , Joseph Marina , Ballester Andrew M. , Metyas Samy 
Published: January 2024

Abstract:
Fibromyalgia (FM) is a complex, widespread pain disorder characterized by symptoms
such as fatigue, sleep deprivation, mental fog, mood swings, and headaches. Currently, there are
only three FDA-approved medications for FM patients: duloxetine, milnacipran, and pregabalin,
with outcomes frequently being inadequate.
This research team aims to investigate the effects of diet and lifestyle modifications on FM, with
emphasis on anti-inflammatory diet, antioxidants, and gluten-free diets, as well as supplementation
with Magnesium, CQ10, and Vitamin D, microbiome, sleep, exercise, and cognitive behavioral
therapy. We reviewed the pathophysiology of certain foods that can be proinflammatory with
the release of cytokines leading to activation of pain, fatigue and aggravation of the majority of Fibromyalgia
symptoms. A literature review was performed by identifying FM articles published between
1994 and 2022 via PubMed and EMBASE databases, with particular emphasis on randomized
controlled trials, meta-analysis, and evidence-based treatment guidelines. This review article
was completed by a comprehensive narrative review process, in which our team systematically
examined relevant scientific literature to provide a comprehensive overview of the significant
role that diet and other lifestyle modifications play in mediating symptoms of Fibromyalgia.
We propose that diet modifications and lifestyle changes, such as sleep, exercise, and weight loss,
can be important steps in managing FM.
Impact of COVID-19 on Endometriosis Patients: An Integrative Review
Authors: Behboodi Moghadam Zahra , Namazi Masoumeh 
Published: January 2024

Background:
During the Covid-19 pandemic, people's lives worldwide have undergone extensive changes. The pandemic has worsened the condition of patients with chronic diseases like women with endometriosis.

Objective:
This study aims to summarize available evidence on the impact of the COVID-19 pandemic on physical symptoms, mental health, and medical care of patients with endometriosis.

Methods:
In the present integrative review using PRISMA guidelines, related articles published
from December 2019 to July 2023 in databases including MEDLINE, Science Direct, Scopus, and
Google Scholar in the English language were extracted.

Results:
After evaluating the criteria for inclusion and exclusion, a total of 23 articles were chosen
and examined. This study represents an open window to investigate the impact of COVID-19 on
women with endometriosis. The COVID-19 pandemic has affected the symptoms, mental well-being, and medical care of women with endometriosis.

Conclusions:
There is a perceived necessity to provide supportive care for patients during pandemic restrictions. Remote work has had an unanticipated advantage, and it is recommended that women with endometriosis continue to work from home after COVID-19 to maintain their workplace
effectiveness.
An Insight into the Effect of Schiff Base and their d and f Block Metal Complexes on
Various Cancer Cell Lines as Anticancer Agents: A Review
Authors: Presenjit  , Chaturvedi Shubhra , Singh Akanksha , Gautam Divya , Singh Kaman , Mishra Anil Kumar 
Published: January 2024

Abstract:
Over the last few decades, an alarming rise in the percentage of individuals with cancer and those with
multi-resistant illnesses has forced researchers to explore possibilities for novel therapeutic approaches. Numerous
medications currently exist to treat various disorders, and the development of small molecules as anticancer
agents has considerable potential. However, the widespread prevalence of resistance to multiple drugs in cancer
indicates that it is necessary to discover novel and promising compounds with ideal characteristics that could
overcome the multidrug resistance issue. The utilisation of metallo-drugs has served as a productive anticancer
chemotherapeutic method, and this approach may be implemented for combating multi-resistant tumours more
successfully. Schiff bases have been receiving a lot of attention as a group of compounds due to their adaptable
metal chelating abilities, innate biologic properties, and versatility to tweak the structure to optimise it for a specific
biological purpose. The biological relevance of Schiff base and related complexes, notably their anticancer
effects, has increased in their popularity as bio-inorganic chemistry has progressed. As a result of learning about
Schiff bases antitumor efficacy against multiple cancer cell lines and their complexes, researchers are motivated
to develop novel, side-effect-free anticancer treatments. According to study reports from the past ten years, we
are still seeking a powerful anticancer contender. This study highlights the potential of Schiff bases, a broad class
of chemical molecules, as potent anticancer agents. In combination with other anticancer strategies, they enhance
the efficacy of treatment by elevating the cytotoxicity of chemotherapy, surmounting drug resistance, and promoting
targeted therapy. Schiff bases also cause cancer cell DNA repair, improve immunotherapy, prevent angiogenesis,
cause apoptosis, and lessen the side effects of chemotherapy. The present review explores the development
of potential Schiff base and their d and f block metal complexes as anticancer agents against various cancer
cell lines.
Glutamate Receptors and C-ABL Inhibitors: A New Therapeutic
Approach for Parkinson's Disease
Authors: Shejul Priya P. , Doshi Gaurav M. 
Published: January 2024

Abstract:
Parkinson's disease (PD) is the second-most prevalent central nervous system (CNS)
neurodegenerative condition. Over the past few decades, suppression of BCR-Abelson tyrosine kinase
(c-Abl), which serves as a marker of -synuclein aggregation and oxidative stress, has shown
promise as a potential therapy target in PD. c-Abl inhibition has the potential to provide neuroprotection
against PD, as shown by experimental results and the first-in-human trial, which supports
the strategy in bigger clinical trials. Furthermore, glutamate receptors have also been proposed as
potential therapeutic targets for the treatment of PD since they facilitate and regulate synaptic
neurotransmission throughout the basal ganglia motor system. It has been noticed that pharmacological
manipulation of the receptors can change normal as well as abnormal neurotransmission
in the Parkinsonian brain. The review study contributes to a comprehensive understanding of the
approach toward the role of c-Abl and glutamate receptors in Parkinson's disease by highlighting
the significance and urgent necessity to investigate new pharmacotherapeutic targets. The article
covers an extensive insight into the concept of targeting, pathophysiology, and c-Abl interaction
with α-synuclein, parkin, and cyclin-dependent kinase 5 (Cdk5). Furthermore, the concepts of Nmethyl-
D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
(AMPA) receptor, and glutamate receptors are discussed briefly. Conclusion: This review article
focuses on in-depth literature findings supported by an evidence-based discussion on pre-clinical
trials and clinical trials related to c-Abl and glutamate receptors that act as potential therapeutic
targets for PD.
Can Rosuvastatin Reduce the Risk of Thrombosis in Patients with Hypercholesterolemia with its Effect on Coagulation Factors and Homocysteine Levels?
Authors: Behnam Mostafa , Deyhim Mohammad Reza , Yaghmaei Parichehreh 
Published: January 2024

Background and Objective:
Hypercholesterolemia is one of the main risk factors for
vascular thrombosis in individuals. Therefore, the use of statins is very effective in reducing cholesterol
and can reduce the risk of thrombosis in these patients. Rosuvastatin, a member of the
statin family which, inhibits cholesterol synthesis. Very few studies have been done in relation to
how rosuvastatin can affect thrombosis. So, this research has been tried whether rosuvastatin can
have an effect on coagulation factors and homocysteine as risk factors for thrombosis in
hypercholesterolemia?

Methods:
In this experimental study, 60 patients (30 men and 30 women with a mean age of 40-
70 years) diagnosed with hypercholesterolemia (cholesterol > 250 mg/dl) participated in this
research. 30 patients were prescribed rosuvastatin (20 mg/day), and 30 patients were simultaneously
taken placebo for three months. All parameters, including FVIII, FV, Fibrinogen, DDimer,
plasma homocysteine level and lipid profile, were measured before and after treatment.
All the results were statistically compared between the two groups.

Results:
In patients who took rosuvastatin, the drug was able to significantly reduce the concentrations
of total cholesterol, triglycerides, and low-density lipoprotein (LDL) (P <0.001). Also,
rosuvastatin was able to reduce the concentrations of homocysteine significantly, D-Dimer
(P < 0.001), coagulation factor VIII and factor V (P < 0.05). In patients with hypercholesterolemia
who took the placebo, did not affect the mentioned variables (P > 0.05).

Conclusion:
According to the results, it seems that rosuvastatin may be able to reduce the risk of
thrombosis in patients by affecting coagulation factors and homocysteine levels.
Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in
Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets
Authors: Shahcheraghi Seyed Hossein , Roshani Asl Elmira , Lotfi Malihe , Ayatollahi Jamshid , Khaleghinejad Seyed Hossein , Aljabali Alaa A.A. , Bakshi Hamid A. , El-Tanani Mohamed , Charbe Nitin B. , Serrano-Aroca Ángel , Mishra Vijay , Mishra Yachana , Goyal Rohit , Hromić-Jahjefendić Altijana , Uversky Vladimir N. , Lotfi Marzieh , Tambuwala Murtaza M. 
Published: January 2024

Abstract:
Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from
astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements
in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical
drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates
the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation.
The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes
deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1,
and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted
the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting
critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various
types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs),
have been shown to control multiple target genes and significantly contribute to the carcinogenesis
of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM.
This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on
the Notch signaling pathway in GBM.
N-Stearoylethanolamine Exerts Cardioprotective Effects in Old Rats
Authors: Kosiakova Halyna , Berdyshev Andrii , Horid’ko Tetyana , Meged Olena , Klimashevsky Vitaliy , Matsokha Roza , Tkachenko Oksana , Asmolkova Valentina , Kvitnitskaya-Ryzhova Tetyana , Luhovskyi Serhii , Klymenko Pavlo , Hula Nadiya 
Published: January 2024

Background:
Aging is associated with the slowing down of metabolic processes, diminished
physiological processes, changes in hormonal activity and increasing exposure to oxidative
stress factors and chronic inflammation. The endocannabinoid system (ECS) is a major
signaling network that plays a pro-homeostatic role in the central and peripheral organs of the
human body. A class of minor lipids, N-acylethanolamines (NAEs), which do not activate cannabinoid
receptors, except for anandamide, but can potentiate the action of endocannabinoids
and have a wide spectrum of biological activity and significant adaptogenic potential, belongs to
ECS. The results of different studies over the past decades have established the protective effect
of NAE on many pathological conditions.

Objective:
This study aimed to investigate the cardioprotective effects of C18:0
NAE— N-stearoylethanolamine (NSE) in aged rats. In this study, we focused on investigating
the effects of C18:0 NAE— N-stearoylethanolamine (NSE) on the intensity of oxidative/
nitrosative stress, antioxidant potential, lipoprotein profile and inflammation markers of
blood plasma, phospholipid composition and age-related morphological changes of old rat heart
tissues.

Methods:
The study was conducted on Sprague Dawley male laboratory rats. The three groups of
rats were involved in the study design. The first group consisted of young rats aged 4 months
(n=10). The second (n=10) and third (n=10) groups included old rats aged of 18 months. Rats from
the third group were administered a per os aqueous suspension of NSE at a dose of 50 mg/kg of
body weight daily for 10 days. All groups of rats were kept on a standard vivarium diet. The blood
plasma, serum, and heart of rats were used for biochemical and histological analysis.

Results:
The cardioprotective effect of N-stearoylethanolamine in old rats was established,
which was expressed in the normalization of the antioxidant system condition and the level of
proinflammatory cytokines, positive modulation of blood plasma and lipoprotein profile, normalization
of heart tissue lipid composition, and significant reduction in age-related myocardium
morphological changes.

Conclusion:
The revealed effects of N-stearoylethanolamine can become the basis for developing
a new drug for use in complex therapy to improve the quality of life of older people.
The Prospective Applications of Arising Nanostructured Dielectric
Materials in Storage of Energy: A Comprehensive Review
Authors: Swain Suryakanta , Samal Himansu Bhusan , Satpathy Santosh , Jena Bikash Ranjan , Pattnaik Gurudutta , Bashar Sheerin , Barad Sonu 
Published: January 2024

Background:
The manufacture and study of innovative materials that enable the availability
of relevant technologies are vital in light of the energy demands of various human activities
and the need for a substantial shift in the energy matrix.

Objective:
A strategy based on the creation of enhanced applications for batteries has been devised
to reduce the conversion, storage, and feeding of renewable energy like fuel cells and electrochemical
capacitors.

Methods:
Conductive polymers (CP) can be utilised instead of traditional inorganic chemicals.
Electrochemical energy storage devices with similar capabilities can be built using approaches
based on the production of composite materials and nanostructures.

Results:
CP's nanostructuring is notable for its concentration on synergistic coupling with other materials,
which sets it apart from other nanostructures that have been developed in the preceding two
decades. This is due to the fact that, when paired with other materials, their distinctive morphology
and adaptability significantly enhance performance in areas like the suppression of ionic diffusion
trajectories, electronic transport and the improvement of ion penetrability and intercalation spaces.

Conclusion:
The present study forecasts the wide-ranging modern applications of diverse
nanostructured dielectric materials along with its future prospectives. The potential contributions of
nanostructured carbon nanotubes to the development of innovative materials for energy storage devices
are also critically discussed in this context, which delivers a summary of the present state of
information on this emerging topic.
Potentials of TPC and TFC as Free Radical Scavengers and Microbial
Growth Inhibitors in Himalayan Endemic Artemisia sieversiana Ehrhl
Ex Willd. (Asteraceae) Plant from Northeastern, Pakistan
Authors: Hussain Adil , Rasheed Hassam , Khan Muhammad A. , Bokhari Syed A.I. 
Published: January 2024

Background:
In various microorganisms, various defense mechanisms have evolved against the commercially available antimicrobial agents with increased resistance. Natural antimi-crobial agents of plant origin are better alternatives when an infectious disease arises due to resistant microbial strains. Here, we have evaluated the efficacy of total phenolics and total flavonoids with antioxidant and antimicrobial potential of Artemisia sieversiana Ehrhl Ex Willd. plant extracted with methanol, ethyl acetate, ethanol, n-hexane, and chloroform using soxhlet procedures

Methods:
The evaluation of TPC was achieved with Folin-Ciocalteu’s reagent method and quanti-tative estimation of TFC was done with the aluminum chloride colorimetric method. The antioxi-dant activities were estimated using FRSA-DPPH and TAC methods. The inhibitory activities of five solvent extracts of A. sieversiana against 2 gram-positive and 2 gram-negative pathogenic bac-terial strains (B. subtilis, P. aerogenosa, S. aureus, and E. coli) were evaluated using the well dif-fusion technique.

Results:
The highest percentage yields of A. sieversiana extracts were obtained in ethanol (4.8 g, 12.1%) and methanol (4.01 g, 10%), while minimum extract yield was obtained in n-hexane (0.53 g, 1.34%). Both phenolics and flavonoids were higher in ethanol, methanol, and ethyl acetate ex-tracts while minimal in n-hexane extracts. Ethanol extract has shown maximum (69%) DPPH ac-tivity with a lower IC50 value (181 μg/ml), while the highest IC50 values of 330 and 325μg/ml were recorded for n-hexane and ethyl acetate extracts. The ethyl acetate and chloroform extracts dis-played overall highest TAC values. All the tested extracts of A. sieversiana exhibited variable in-hibitory effects in a dose-dependent manner against the tested bacterial strains with minimum 9.08 ± 0.23 to maximum 21.23 ± 7.04 mm inhibition zones. Methanol and ethyl acetate extracts at 2 to 4 mg/ml showed greater MIC results against P. aeruginosa in comparison to the B. subtilis strain.

Conclusion:
The extracts of A. sieversiana have been found to be rich in TPC and TFC with re-markable antibacterial and antioxidant efficacies, and the plant extracts could be employed as pos-sible alternatives to synthetic drugs in various nutraceutical and pharmaceutical industries.
Nanoparticles as Catalysts: Exploring Potential Applications
Authors: Basu Shibani , Banik Bimal Krishna 
Published: January 2024

:
Nanoparticles have emerged as highly promising catalysts due to their unique physical
and chemical properties arising from their small size and high surface area–to–volume ratio. This
review delves into the diverse applications of nanoparticles as catalysts in various chemical reactions.
A key advantage lies in their substantial surface area–to–volume ratio, facilitation, enhanced
accessibility of reactants, and heightened interaction with the catalyst surface. This distinctive characteristic
results in improved catalytic activity and efficiency. Additionally, size-dependent properties,
such as surface plasmon resonance and quantum confinement effects, offer opportunities for
tailoring catalytic behavior. Despite their immense potential, challenges such as synthesis, stability,
toxicity, aggregation, and recyclability require attention. Future research should prioritize scalable
and sustainable synthesis methods, improve catalyst stability under harsh conditions, and ensure
safe handling and disposal. This review provides an overview of the role of nanoparticles as catalysts
and highlights their significance in various fields, highlighting their exceptional performance,
versatility, and environmental benefits.
Differentiation of Restless Genital Syndrome from Persistent Genital Arousal Disorder: A Case Report
Authors: Haghshenas Mandana , Poor Elham Moein 
Published: January 2024

Objective:
Persistent genital arousal disorder (PGAD) presents with a constant
unwelcome sensation of genital arousal. Moreover, restless genital syndrome (RGS) is one
of the restless leg syndrome (RLS) variants

Case Representation:
We aimed to clarify the differences between clinical diagnoses of
these two similar conditions. Assessing the circadian pattern of symptoms, the simultaneous
presence of RLS and restless bladder syndrome, exacerbation of symptoms with caffeine
use, healing with magnesium use, and familial history of RLS helped us with the
differentiation between PGAD and RGS.

Conclusion:
We propose to rule out the diagnosis of RGS in all patients with PGAD
symptoms.
The Effects of Standard Pharmacotherapy on Oxidative Stress Markers in Bipolar Patients: A Systematic Review
Authors: Rahsepar Sara , Karizaki Golnaz Abbasi , Samadi Sara , Jomehzadeh Vahid , Sadjadi Seyed Alireza , Mohammadpour Amir Hooshang , Arasteh Omid , Johnston Thomas P. , Sahebkar Amirhossein 
Published: January 2024

Background:
Bipolar disorder is a complex mental disorder with a multifactorial
pathology. Meta-analyses have shown that bipolar disorder is associated with imbalanced
oxidative status, which can contribute to disease progression. Therefore, restoring
the oxidative imbalance could be beneficial in the treatment of bipolar disorder. The firstline
pharmacotherapy for bipolar disorder is lithium, anticonvulsants (particularly sodium
valproate), and atypical antipsychotics. In the present review, we sought to describe the
effects of these first-line medications on oxidative stress in bipolar patients.

Methods:
We systematically searched databases through January 2022, including the Web
of Science, PubMed, Scopus, and Embase, with no language or time restrictions. Eligible
articles that assessed oxidative markers in bipolar patients following standard pharmacotherapy
were included.

Result:
According to Newcastle Ottawa and NIH scales, the overall quality of the included
articles was low, and their heterogeneity prevented us from performing a meta-analysis.

Conclusion:
We found that standard medications, especially lithium, can potentially alleviate
oxidative imbalance based on a reduction in oxidative markers, such as TBARs and
MDA, although randomized clinical trials are needed to unequivocally confirm these results.