bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations
Authors: Hendy Dylan A. , Pena Erik S. , Ontiveros‐Padilla Luis , Dixon Timothy A. , Middleton Denzel D. , Williamson Grace L. , Lukesh Nicole Rose , Simpson Sean R. , Stiepel Rebeca T. , Islam Md Jahirul , Carlock Michael A. , Ross Ted M. , Bachelder Eric M. , Ainslie Kristy M. 
Published: December 2023

AbstractInfluenza virus outbreaks are a major burden worldwide each year. Current vaccination strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low immune responses. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin (HA) immunogens subvert the constantly mutating viruses; however, they are poorly immunogenic on their own. To increase the immunogenicity of subunit vaccines such as this, adjuvants can be delivered with the vaccine. For example, agonists of the stimulator of interferon genes (STING) have proven efficacy as vaccine adjuvants. However, their use in high‐risk populations most vulnerable to influenza virus infection has not been closely examined. Here, we utilize a vaccine platform consisting of acetalated dextran microparticles loaded with COBRA HA and the STING agonist cyclic GMP‐AMP. We examine the immunogenicity of this platform in mouse models of obesity, aging, and chemotherapy‐induced immunosuppression. Further, we examine vaccine efficacy in collaborative cross mice, a genetically diverse population that mimics human genetic heterogeneity. Overall, this vaccine platform had variable efficacy in these populations supporting work to better tailor adjuvants to specific populations.
The development of the Psychotherapists' Supervision Preferences Questionnaire—Derived from the Proctor Model
Authors: Fagernäs Simon , Spännargård Åsa , Alfonsson Sven 
Published: December 2023

AbstractBackgroundThe Proctor Model describes three core functions of clinical supervision: formative, restorative and normative. While having high face validity as a tool for measuring supervision preferences that can facilitate the formulation of the supervision contract, its construct validity is unclear, and the literature suggests a more all‐encompassing model by including a reflective component.ObjectiveThe aim of this study was to assess the construct validity of the Proctor Model and use these results to develop a short instrument that can facilitate the formulation of the supervision contract.MethodThrough a literature review and expert discussions, a 28‐item inventory was created. After pilot‐testing and revisions, the inventory was administered to 204 psychotherapists. These data were analysed with factor analysis, leading to a revised version that was enrolled in a second sample of 125 psychotherapists.ResultsFactor analysis of the first sample suggested a five‐factor solution as the formative function consisted of two separate constructs: conceptual (receiving role of the therapist and theoretical focus) and experiential (active role of the therapist, skill‐based and feedback‐oriented). The restorative function composed of sharing thoughts and feelings and being validated and recognised. Pre‐theorised restorative items describe an active handling of distressing feelings loaded on the reflective function. Analysis of the second sample confirmed the suggested five‐factor structure and gave support for overall replicated psychometric properties. Regression and correlation analyses showed preliminary evidence for convergent and divergent validity.ConclusionThe results provide a more nuanced understanding of the Proctor Model and provide the field with a psychometrically sound instrument for the formulation of the supervision contract.
Microbial Biomanufacturing Using Chemically Synthesized Non‐Natural Sugars as the Substrate
Authors: Tabata Hiro , Nishijima Hiroaki , Yamada Yuki , Miyake Rika , Yamamoto Keisuke , Kato Souichiro , Nakanishi Shuji 
Published: December 2023

AbstractThe bioproduction of valuable materials using biomass sugars is attracting attention as an environmentally friendly technology. However, its ability to fulfil the enormous demand to produce fuels and chemical products is limited. With a view towards the future development of a novel bioproduction process that addresses these concerns, this study investigated the feasibility of bioproduction of valuable substances using Corynebacterium glutamicum (C. glutamicum) with a chemically synthesized non‐natural sugar solution. Cells were grown using the synthesized sugar solution as the sole carbon source and they produced lactate under oxygen‐limited conditions. It was also found that some of the sugars produced by the series of chemical reactions inhibited cell growth since prior removal of these sugars increased the cell growth rate. The results obtained in this study indicate that chemically synthesized sugars have the potential to resolve the concerns regarding future biomass sugar supply in microbial biomanufacturing.
Manganese(I) Catalyzed CO2 Reduction Processes in Homogenous Phase
Authors: Kostera Sylwia , Gonsalvi Luca 
Published: December 2023

AbstractThe catalytic activation of carbon dioxide (CO2) can be a promising tool for the use of this abundant, non‐flammable and non‐toxic gas as feedstock for C1 chemical synthesis, in particular for bulk products such as formic acid (HCOOH) and methanol (CH3OH). The key for successful, widespread use of CO2 is the design and application of efficient, thermally robust and cheap catalysts. In the last decade, the use of earth‐abundant transition metal complexes, in particular those of 3d metals, has shown promising results. In this review article, a comprehensive summary of the main catalytic systems described in the literature for homogeneous Mn(I)‐catalyzed CO2 reduction processes (hydrogenation, hydroboration and hydrosilylation) will be described, with particular attention to the effect of stabilizing ligands, reaction conditions and need for additives, together with mechanistic details often obtained by a combination of experimental data and DFT calculations.
Synthesis and dark state EPR properties of PDI‐trityl dyads and triads
Authors: Kopp Kevin , Westhofen Lars , Hett Tobias , Felix Schwering‐Sohnrey Merlin , Mayländer Maximilian , Richert Sabine , Schiemann Olav 
Published: December 2023

AbstractCovalently‐linked chromophore‐radical systems with their unique optical and magnetic properties are useful for applications in, e. g., quantum information science. To expand the catalog of molecular systems, we synthesized and characterized six novel chromophore–radical and radical‐chromophore‐radical systems employing derivatives of perylene diimide (PDI) as the chromophore and trityl as the radical. The EPR properties of these compounds were evaluated in solution at cryogenic and room temperatures. In addition, the electron spin‐spin coupling in the two bistrityl systems was investigated using DQC measurements. The presented results serve as a basis for further spectroscopic investigations under photoexcitation of the PDI core.
Der Nationale Wasserstoffrat der deutschen Bundesregierung
Authors: Maletzko Annabelle , Wurster Sebastian , Pinkwart Karsten 
Published: December 2023

AbstractFür die Erreichung der ambitionierten Klimaziele ist der Übergang von fossilen Energieträgern zu erneuerbaren Ressourcen entscheidend. Wasserstoff spielt dabei eine zentrale Rolle. Die deutsche Bundesregierung hat im Juni 2020 die Nationale Wasserstoffstrategie verabschiedet und den Nationalen Wasserstoffrat berufen. Der Rat besteht aus 26 hochrangigen Experten aus Wirtschaft, Wissenschaft und Zivilgesellschaft. Seine Aufgabe ist es, den Staatssekretärsausschuss für Wasserstoff durch Vorschläge und Handlungsempfehlungen bei der Umsetzung und Weiterentwicklung der Strategie zu beraten und zu unterstützen.
Chemical and photophysical properties of amine functionalized bis‐NHC‐pyridine‐RuII complexes
Authors: Fritsch Lorena , Vukadinovic Yannik , Lang Moritz , Naumann Robert , Bertrams Maria‐Sophie , Kruse Ayla , Schoch Roland , Müller Patrick , Neuba Adam , Dierks Philipp , Lochbrunner Stefan , Kerzig Christoph , Heinze Katja , Bauer Matthias 
Published: December 2023

AbstractThe effects of backbone amine functionalization in three new homoleptic C^N^C type ruthenium(II) complexes bearing a tridentate bis‐imidazole‐2‐ylidene pyridine ligand framework are characterized and studied by single crystal diffraction, electrochemistry, optical spectroscopy and transient absorption spectroscopy in combination with ab initio DFT calculations. Functionalization by dimethylamine groups in 4‐position of the pyridine backbone significantly influences the properties of the complexes as revealed by comparison with the unfunctionalized references. As a result of the amine functionalization, a higher molar absorption coefficient of the MLCT bands, a decreased photoluminescence quantum yield at room temperature together with a shortened excited state lifetime but an improved photostability is observed. Introduction of electron donating and withdrawing groups at the NHC unit modifies the electronic and optical properties, such as the oxidation potential, absorption and emission properties, and the lifetimes of the excited states.
Decoding the rhabdoid riddle in liver: A rare case of primary hepatic malignant rhabdoid tumor with a comprehensive literature review
Authors: Kerkar Aadya , Gupta Parikshaa , Azeez Ajmeera , Bhatia Anmol , Gupta Nalini , Bansal Deepak 
Published: December 2023

AbstractMalignant rhabdoid tumor of the liver is a rare, highly aggressive primary hepatic malignancy occurring primarily in infants. Establishing a definitive diagnosis is challenging due to its rarity, non‐specific clinicoradiologic findings, and overlapping morphologic features. Herein, we present the cytomorphologic and immunocytochemical characteristics of a rare case of primary hepatic Malignant rhabdoid tumor (MRT) in an infant. A 5‐month‐old female child presented with progressively increasing firm mass in the upper abdomen, progressive pallor, sudden onset respiratory distress, and difficulty feeding. On examination, the child had massive, firm nodular hepatomegaly. Ultrasonography of the abdomen revealed a heterogeneously hypoechoic lesion in the left lobe of the liver. Serum alpha‐fetoprotein levels were within normal limits. An ultrasound‐guided fine‐needle aspiration cytology (FNAC) from the liver mass showed predominantly dispersed large, markedly pleomorphic tumor cells with round to oval eccentrically placed nuclei, prominent nucleoli, and moderate cytoplasm. On immunocytochemistry, tumor cells showed positivity for vimentin, cytokeratin, and EMA and demonstrated a loss of INI1, confirming the diagnosis of MRT. The index report highlights the distinctive clinicopathological features of a hepatic malignant rhabdoid tumor along with the key differential diagnoses, which may pose a diagnostic conundrum. A high index of clinical suspicion and a thorough understanding of its cytomorphological and immunochemical characteristics are crucial for an accurate diagnosis.
Flow dynamics as Froude‐supercritical turbidity currents encounter metre‐scale slope minibasin topography
Authors: Englert Rebecca G. , Hubbard Stephen M. , Romans Brian W. , Kaempfe Sebastian , Bell Daniel , Nesbit Paul R. , Stright Lisa 
Published: December 2023

AbstractSeafloor topography can affect turbidity current dynamics on deep‐water slopes, significantly influencing the dispersal of sediment. Despite the common occurrence of topographic complexity, there are few detailed investigations of topographic interactions and their effect on downslope flow evolution in intraslope environments. In this study, the sedimentology and architecture of an Upper Cretaceous intraslope fan succession deposited within an extensional, fault‐bound minibasin are described from a rare, well‐exposed, near‐continuous, oblique depositional‐dip outcrop of the Tres Pasos Formation, Chile. The 2 to 8 m thick studied interval transitions downslope from high‐energy heterolithic strata, including metre‐scale steep‐faced scours, to non‐amalgamated thick‐bedded sandstones. Abrupt increases in sandstone percentage, sandstone bed thickness and grain size occur on the hangingwall blocks of south‐east and north‐east‐dipping normal faults that bound the minibasin. Sandstone beds are dominated by backset or wavy low‐angle stratification proximally, contain compositional banding near faults, and are characterised by increased proportions of planar laminated and structureless turbidite divisions downslope along the transect. Experimental observations of turbidity current interactions with topography are synthesised into a qualitative framework, which is used to interpret flow processes and characteristics from deposit trends. The results reconstruct the response of Froude‐supercritical, stratified turbidity currents with denser basal layers when encountering metre‐scale fault scarps. The analysis shows that metre‐scale topographic features can substantially alter the flow properties of stratified turbidity currents, and their downslope flow evolution to include the development of transitional, depositional and flow‐stripped sediment gravity currents. However, in comparison to base‐of‐slope settings, overall flow conditions are interpreted to be more uniform over slope breaks and zones of flow expansion in a partially confined intraslope environment. These findings have considerable implications for understanding flow response to similar scale morphological features on the seafloor and the potential for flow transformations in intraslope settings.
Electrothermal model of all‐solid‐state lithium battery with composite solid‐state electrolyte
Authors: Liu Zhao , Peng Shang , Xiaokaiti Pairuzha , Zhang Juan , You Hongxin , Abudula Abuliti , Guan Guoqing 
Published: December 2023

AbstractFor secondary batteries, thermal runaway has become the main issue, and how to solve it is full of challenges. In this work, a universal thermal model for lithium ion batteries (LIBs) was proposed, which was validated by using commercially available 18650 batteries as well as testing the electrochemical parameters of a Poly(ethylene oxide)(PEO)–bis(trifluoromethane)sulfonimide lithium salt(LiTFSI)–Li2MnO3(LMO) (PLL) composite solid‐state electrolyte (CSSE), while a computational model was developed for all‐solid‐state LIBs (ASSLIBs) based on PLL CSSE. The simulation results show that the maximum temperature of ASSLIBs based on PLL CSSE and commercial standards are both significantly lower than the thermal runaway temperature of solid‐state electrolyte. However, as the temperature of the battery varies greatly under different operating conditions, it will cause great difficulties in the control of other ancillary components and even finally lead to certain safety issues. Therefore, from the perspective of performance and practical application, the CSSE should be improved toward improving the ionic conductivity at low temperatures to have more commercial prospects, and lower interfacial impedance and a higher lithium ion migration number would also be beneficial for optimizing the thermal behavior of ASSLIBs to achieve better commercial prospects.
Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE‐HF
Authors: Clephas Pascal R. D. , Malgie Jishnu , Schaap Jeroen , Koudstaal Stefan , Emans Mireille , Linssen Gerard C. M. , de Boer Grytsje A. , van Heerebeek Loek , Borleffs C. Jan Willem , Manintveld Olivier C. , van Empel Vanessa , van Wijk Sandra , van den Heuvel Mieke , da Fonseca Carlos , Damman Kevin , van Ramshorst Jan , van Kimmenade Roland , van de Ven Arjen R. T. , Tio René A. , van Veghel Dennis , Asselbergs Folkert W. , de Boer Rudolf A. , van der Meer Peter , Greene Stephen J. , Brunner‐La Rocca Hans‐Peter , Brugts Jasper J. 
Published: December 2023

AbstractAimsCurrent heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline‐directed medical therapy (GDMT) regarding the sequencing of drugs and timely reaching target dose. It is largely unknown how the paradigm shift from a serial and sequential approach for drug therapy to early parallel application of the four drug classes will be executed in daily clinical practice, as well as the reason clinicians may not adhere to new guidelines. We present the design and rationale for the real‐world TITRATE‐HF study, which aims to assess sequencing strategies for GDMT initiation, dose titration patterns (order and speed), intolerance for GDMT, barriers for implementation, and long‐term outcomes in patients with de novo, chronic, and worsening HF.Methods and resultsA total of 4000 patients with HFrEF, HF with mildly reduced ejection fraction, and HF with improved ejection fraction will be enrolled in >40 Dutch centres with a follow‐up of at least 3 years. Data collection will include demographics, physical examination and vital parameters, electrocardiogram, laboratory measurements, echocardiogram, medication, and quality of life. Detailed information on titration steps will be collected for the four GDMT drug classes. Information will include date, primary reason for change, and potential intolerances. The primary clinical endpoints are HF‐related hospitalizations, HF‐related urgent visits with a need for intravenous diuretics, all‐cause mortality, and cardiovascular mortality.ConclusionsTITRATE‐HF is a real‐world multicentre longitudinal registry that will provide unique information on contemporary GDMT implementation, sequencing strategies (order and speed), and prognosis in de novo, worsening, and chronic HF patients.
Risk of readmission and death after hospitalization for worsening heart failure: Role of post‐discharge follow‐up visits in a real‐world study from the Grand Est Region of France
Authors: Baudry Guillaume , Pereira Ouarda , Duarte Kévin , Ferreira João Pedro , Savarese Gianluigi , Welter Adeline , Tangre Philippe , Lamiral Zohra , Agrinier Nelly , Girerd Nicolas 
Published: December 2023

AimsPatients who experience hospitalizations due to heart failure (HF) face a significant risk of readmission and mortality. Our objective was to evaluate whether the risk of hospitalization and mortality following discharge from HF hospitalization differed based on adherence to the outpatient follow‐up (FU) protocol comprising an appointment with a general practitioner (GP) within 15 days, a cardiologist within 2 months or both (termed combined FU).Methods and resultsWe studied all adults admitted for a first HF hospitalization from 2016 to 2020 in France's Grand Est region. Association between adherence to outpatient FU and outcomes were assessed with time‐dependent survival analysis model. Among 67 476 admitted patients (mean age 80.3 ± 11.3 years, 53% women), 62 156 patients (92.2%) were discharged alive and followed for 723 (317–1276) days. Combined FU within 2 months was used in 21.1% of patients, with lower rates among >85 years, women, and those with higher comorbidity levels (p < 0.0001 for all). Combined FU was associated with a lower 1‐year death or rehospitalization (adjusted hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.88–0.94, p < 0.0001) mostly related to lower mortality (adjusted HR 0.65, 95% CI 0.62–0.68, p < 0.0001) whereas HF readmission was higher (adjusted HR 1.19, 95% CI 1.15–1.24, p < 0.0001). When analysing components of combined FU separately, 1‐year mortality was more related to cardiologist FU (HR 0.65, 95% CI 0.62–0.67, p < 0.0001), than GP FU (HR 0.87, 95% CI 0.85–0.90, p < 0.0001).ConclusionCombined FU is carried out in a minority of patients following HF hospitalization, yet it is linked to a substantial reduction in 1‐year mortality, albeit at the expense of an increase in HF hospitalizations.
Pyrazolyldiazonium Salts in the Synthesis of 4‐Amino‐1,3’‐bipyrazoles
Authors: Barabash Oksana V. , Ostapiuk Yurii V. , Ostapiuk Mary Y. , Herzberger Colin , Kravets Mykola , Schmidt Andreas 
Published: December 2023

AbstractAn efficient protocol for the synthesis of fluorescent 4‐amino‐1,3′‐bipyrazoles, which are substituted at the positions N‐1′, C‐4′, C‐3 and C‐5, is described. By a two‐step synthetic strategy, an initial azo coupling of ethyl cyanoacetate and various 1‐alkylpyrazolyldiazonium chlorides gave substituted ethyl 2‐cyano‐2‐(2‐(pyrazol‐3‐yl)hydrazine‐ylidene)acetates, which were subsequently subjected to Thorpe‐Ziegler type cyclisation reactions to yield the title compounds.
Equivalent static methods for seismic design of straight integral abutment bridges
Authors: Marchi Andrea , Franchin Paolo 
Published: December 2023

AbstractIntegral abutment bridges (IABs) are becoming the solution of choice in the low to mid‐length ranges because of their low cost compared with traditional solutions and their good performance under seismic actions. The main drawback of these bridges is the need to consider soil‐structure interaction to assess their performance, a problem that is more pronounced for actions implying horizontal deck movements, such as temperature or the specific focus of this paper, that is, seismic action. In IAB design, simplified models are often used, where soil‐structure interaction is modeled by means of beams on non‐linear Winkler springs for the evaluation of seismic behavior. This paper, starting from an existing non‐linear dynamic model (NLDM) that describes IABs longitudinal seismic response, derives two equivalent static models: one non‐linear and the other linear, for displacement‐ or force‐based design respectively. A parametric study is carried out to assess the static models performance in terms of the main design internal actions versus the NLDM. Finally, the assessed model errors are discussed in the context of partial factors safety format.
Thermal stability of film forming amines‐based corrosion inhibitors in high temperature power plant water solutions
Authors: Vidojkovic Sonja , Mijajlovic Miroslav , Lindeboom Ralph E. F. , Jovicic Vojislav 
Published: December 2023

AbstractFilm forming amines (FFA) are corrosion inhibitors added to power plant water. The major concern associated with their application is the thermal stability in the high temperature power plant water medium, along with the risk of decomposition into low molecular weight organic acids that can cause corrosive damages in the water/steam cycle. However, there is still a lack of sufficient data on the thermal stability of FFA corrosion inhibitors. This paper presents a comprehensive critical review and state‐of‐the‐art assessment of the results obtained from studying the thermolysis of FFA corrosion inhibitors in power plant water/steam cycle conditions, highlighting the relevance for practical application and research needs. Temperature, exposure time, initial concentration, and alkalizing agents were identified as key factors influencing the thermal stability of FFA in high temperature power plant water. Organic acids are found in concentrations harmless to metal tubes. Advanced scientific background information and additional research are required on this topic.