bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyse des motivations associées à la pratique du chemsex selon l’orientation sexuelle
Authors: This Jeanne , Lafortune David , Flores-Aranda Jorge 
Published: October 2023

Problématique et objectif : La consommation des substances en contexte sexuel – aussi connu sous le nom de chemsex – a surtout été documentée chez les hommes gais, bisexuels ou ayant des relations sexuelles avec d’autres hommes (gbHARSAH), avec de rares études incluant des hommes hétérosexuels. Par ailleurs, les motivations associées au chemsex demeurent sous-documentées, nonobstant l’orientation sexuelle primaire rapportée. Cette étude qualitative exploratoire visait à décrire les motivations associées à la pratique du chemsex chez les hommes et à explorer les possibles différences selon leur orientation sexuelle primaire.
Méthodologie : Onze hommes cisgenre (>18ans) rapportant avoir consommé en contexte sexuel au moins une des substances associées au chemsex (méthamphétamine, cocaïne, kétamine, MDMA ou GHB) dans la dernière année ont participé à un entretien semi-directif. Une analyse thématique a été réalisée en utilisant la théorie de l’autodétermination (Ryan et Deci, 2000) pour organiser et conceptualiser les thèmes émergents relatifs aux motivations intrinsèques et extrinsèques associées à la pratique du chemsex.
Résultats : Les motivations extrinsèques rapportées faisaient référence à (1) l’influence de normes sociosexuelles intériorisées ou (2) des partenaires sexuels dans l’initiation ou le maintien de la pratique du chemsex. Les motivations intrinsèques incluaient le désir (1) d’améliorer la performance sexuelle et des sensations physiques ; (2) de réduire les inhibitions lors d’interactions sexo-relationnelles ; (3) de favoriser la connexion émotionnelle au.x partenaire.s ; (4) d’atténuer l’impact d’émotions ou d’événement douloureux ou alors (5) de combler un besoin lié à une dépendance aux substances.
Discussion : Nos résultats relèvent les facettes multiples du chemsex en matière de facteurs individuels, relationnels ou culturels influençant sa pratique, de même que le caractère heuristique du modèle de l’autodétermination pour distinguer les profils d’utilisateurs relativement à leurs motivations et leur orientation sexuelle primaire.
L’évaluation des limitations à l’emploi en contexte de dépendances : une question d’équité
Authors: Giguère Nadia , Handfield Stéphane , Barbeau David , Beaulieu Marie-Dominique 
Published: October 2023

(Ré)intégrer le marché du travail et se maintenir en emploi représente un grand défi pour les personnes traitées pour un trouble lié à l’usage des opioïdes. Ces personnes se tournent donc souvent vers les programmes d’aide financière, qui peuvent être majorés de 57 % si un rapport médical documentant les limitations fonctionnelles donne lieu à une reconnaissance de contraintes sévères à l’emploi. L’évaluation de ces limitations est cependant un acte médical complexe, particulièrement pour des patients ayant des troubles liés à l’usage de drogue ou d’alcool.
L’étude de cas réalisée dans un centre de traitement de la dépendance aux opioïdes visait à documenter : 1) les critères utilisés par les professionnels impliqués dans l’évaluation ; et 2) le vécu des personnes requérantes. Les données recueillies proviennent d’entretiens menés auprès de sept professionnels et 18 usagers et de deux groupes de discussion formés d’une vingtaine de professionnels.
L’analyse thématique montre que cinq types de critères sont utilisés par les professionnels : 1) les facteurs médicaux et psychosociaux ; 2) l’employabilité de la personne ; 3) sa crédibilité ; 4) les impacts potentiels de la reconnaissance des contraintes à l’emploi et de l’accès aux prestations majorées ; 5) leurs valeurs individuelles. Également cinq thèmes principaux émergent des entrevues avec les usagers : 1) l’anxiété liée au processus médico-administratif ; 2) la difficulté à accepter le refus de reconnaissance des contraintes ; 3) les impacts anticipés ou ressentis de l’accès aux prestations majorées, qui tendent à montrer le fort potentiel des interventions sur le revenu ; 4) la grande valeur accordée au travail et le soulagement de voir reconnaître ses difficultés en emploi ; 5) la variabilité des réactions des usagers à l’égard de l’officialisation d’un diagnostic.
Des pistes de réflexion sont proposées pour l’évaluation des limitations à l’emploi dans une perspective de promotion de la santé. Celles-ci incluent une approche interdisciplinaire afin de faciliter la prise en compte des déterminants sociaux de la santé dans l’évaluation.
Mining Google Trends data for nowcasting and forecasting colorectal cancer (CRC) prevalence
Authors: Tudor Cristiana , Sova Robert Aurelian 
Published: October 2023

Background
Colorectal cancer (CRC) is the third most prevalent and second most lethal form of cancer in the world. Consequently, CRC cancer prevalence projections are essential for assessing the future burden of the disease, planning resource allocation, and developing service delivery strategies, as well as for grasping the shifting environment of cancer risk factors. However, unlike cancer incidence and mortality rates, national and international agencies do not routinely issue projections for cancer prevalence. Moreover, the limited or even nonexistent cancer statistics for large portions of the world, along with the high heterogeneity among world nations, further complicate the task of producing timely and accurate CRC prevalence projections. In this situation, population interest, as shown by Internet searches, can be very important for improving cancer statistics and, in the long run, for helping cancer research.

Methods
This study aims to model, nowcast and forecast the CRC prevalence at the global level using a three-step framework that incorporates three well-established univariate statistical and machine-learning models. First, data mining is performed to evaluate the relevancy of Google Trends (GT) data as a surrogate for the number of CRC survivors. The results demonstrate that population web-search interest in the term “colonoscopy” is the most reliable indicator to nowcast CRC disease prevalence. Then, various statistical and machine-learning models, including ARIMA, ETS, and FNNAR, are trained and tested using relevant GT time series. Finally, the updated monthly query series spanning 2004–2022 and the best forecasting model in terms of out-of-sample forecasting ability (i.e., the neural network autoregression) are utilized to generate point forecasts up to 2025.

Results
Results show that the number of people with colorectal cancer will continue to rise over the next 24 months. This in turn emphasizes the urgency for public policies aimed at reducing the population's exposure to the principal modifiable risk factors, such as lifestyle and nutrition. In addition, given the major drop in population interest in CRC during the first wave of the COVID-19 pandemic, the findings suggest that public health authorities should implement measures to increase cancer screening rates during pandemics. This in turn would deliver positive externalities, including the mitigation of the global burden and the enhancement of the quality of official statistics.
Prevalence of Autism Among Medicaid-Enrolled Adults
Authors: Rubenstein Eric , Tewolde Salina , Michals Amy , Fox Matthew , Wang Na 
Published: October 2023

ImportanceThe reported prevalence of autism in children has consistently risen over the past 20 years. The concurrent implications for the adult Medicaid system, which insures autistic adults due to low income or disability, have not been studied.ObjectiveTo estimate the prevalence of adults identified as autistic in Medicaid claims data and to examine the prevalence by year, age, and race and ethnicity to understand enrollment patterns.Design, Setting, and ParticipantsThis cohort study used data from a longitudinal Medicaid claims cohort of enrollees aged 18 years or older with a claim for autism at any point from January 1, 2011, to December 31, 2019, and an approximately 1% random sample of all adult Medicaid enrollees. The data were analyzed between February 22 and June 22, 2023.ExposureAdults enrolled in Medicaid with a claim for autism.Main Outcome and MeasuresPrevalence of autism per 1000 Medicaid enrollees for each year was calculated using denominator data from the Centers for Medicare &amp;amp; Medicaid Services weighted to nondisabled population demographic characteristics. Prevalence by race and ethnicity were calculated for study year 2019.ResultsAcross 9 years, 403 028 unique adults had autism claims in their Medicaid records (25.7% female, 74.2% male, 3.3% Asian, 16.8% Black, 12.2% Hispanic, 0.8% Native American, 0.8% Pacific Islander, 74.3% White, and 4.2% of multiple races). Across all ages, autism prevalence increased from 4.2 per 1000 enrollees in 2011 to 9.5 per 1000 enrollees in 2019. The largest increase over the 9 years was in the 25- to 34-year age group (195%), and the smallest increase was in the 55- to 64-year age group (45%). The prevalence of White enrollees was at least 2 times that of the prevalence of every other racial group in all age categories.Conclusions and RelevanceThe study findings suggest that despite difficulties in identifying autism in adults, there is a considerable and growing population of autistic adults enrolled in Medicaid. As children on the autism spectrum become autistic adults, Medicaid is an important insurance provider for an increasing number of autistic adults and can be a valuable resource for understanding the health of the autistic population.
AAPM Medical Physics Practice Guideline 8.b: Linear accelerator performance tests
Authors: Krauss Robert F. , Balik Salim , Cirino Eileen T. , Hadley Austin , Hariharan Navneeth , Holmes Shannon M. , Kielar Kayla , Lavvafi Hossein , McCullough Kiernan , Palefsky Steven , Sawyer J. Phillip , Smith Koren , Tracy Jason , Winter Jeff D. , Wingreen Nicholai E. 
Published: October 2023

AbstractThe purpose of this guideline is to provide a list of critical performance tests to assist the Qualified Medical Physicist (QMP) in establishing and maintaining a safe and effective quality assurance (QA) program. The performance tests on a linear accelerator (linac) should be selected to fit the clinical patterns of use of the accelerator and care should be given to perform tests which are relevant to detecting errors related to the specific use of the accelerator. Current recommendations for linac QA were reviewed to determine any changes required to those tests highlighted by the original report as well as considering new components of the treatment process that have become common since its publication. Recommendations are made on the acquisition of reference data, routine establishment of machine isocenter, basing performance tests on clinical use of the linac, working with vendors to establish QA tests and performing tests after maintenance and upgrades. The recommended tests proposed in this guideline were chosen based on consensus of the guideline's committee after assessing necessary changes from the previous report. The tests are grouped together by class of test (e.g., dosimetry, mechanical, etc.) and clinical parameter tested. Implementation notes are included for each test so that the QMP can understand the overall goal of each test. This guideline will assist the QMP in developing a comprehensive QA program for linacs in the external beam radiation therapy setting. The committee sought to prioritize tests by their implication on quality and patient safety. The QMP is ultimately responsible for implementing appropriate tests. In the spirit of the report from American Association of Physicists in Medicine Task Group 100, individual institutions are encouraged to analyze the risks involved in their own clinical practice and determine which performance tests are relevant in their own radiotherapy clinics.
A “Polymer‐in‐Salt” Solid Electrolyte Enabled by Fast Phase Transition Route for Stable Zn Batteries
Authors: Yan Kang , Fan Yongbo , Hu Fulong , Li Gang , Yang Xueya , Wang Xinyu , Li Xiaomin , Peng Chao , Wang Weijia , Fan Huiqing , Ma Longtao 
Published: October 2023

AbstractSolid polymer electrolyte‐based batteries show great promise because of their safe operating properties, wide voltage window and suitable flexibility. However, low ionic conductivity, low cation transfer number, weak oxidation/reduction resistance and low mechanical strength limit their implementation in Zn ion batteries. Here, w e developed a “polymer‐in‐salt” Zn2+‐conductive solid electrolyte (denoted as 70% salt‐SPE) constructed by a simple and fast phase transition method. The room‐temperature ionic conductivity and the transfer number of the 70% salt‐SPE reaches 1.6 mS cm−1 and 0.78, respectively. Meanwhile, the ZnF2‐rich inorganic/organic hybrid solid electrolyte interface is formed, and the stable voltage window reaches 9.35 V. In consequence, the Zn||Zn symmetric cell continuously cycles over 700 hours at current density of 2 mA cm−2 and the Zn||Cu symmetric battery runs with Coulombic efficiency of >99%. The Zn||MnPBA full battery delivers a discharge specific capacity of 109 mAh g−1 at room temperature and 190 mAh g−1 at 60 °C. Meanwhile, impressive cyclic stability of 6000 cycles with capacity retention of 80% is achieved, which originates from the effectively optimized ion transport action and dendrite‐free Zn plating/stripping.
Enhancement of Thermoelectric Performance in Robust ZnO‐Based Composite Ceramics Driven by A Stepwise Optimization Strategy
Authors: Wang Dianzhen , Gao Yuqi , You Cun , Cheng Jiaen , Liu Zeben , Qiang Yuhan , Lian Min , Ma Xiaoci , Ge Yufei , Chen Yanli , Tao Qiang , Zhu Pinwen 
Published: October 2023

AbstractZnO is a promising high‐temperature thermoelectric (TE) material due to its superior stability and earth abundance. However, the coupling relation between Seebeck coefficient and electrical conductivity on carrier concentration limits the optimum TE performance for most TE materials, especially ZnO. Herein, enhancement of TE performance is achieved via a stepwise optimization strategy composed of carrier concentration optimization and carrier filtering effect for fabricating robust ZnO‐based composite ceramics through a self‐developed specific high‐pressure synthesis followed by spark plasma sintering. Specifically, doping SnO2 provide substantial electrons to surge the carrier concentration. The subsequent compositing Si3N4 nanoparticles results in the unique reaction‐generated Zn2SiO4 nanoprecipitates with a larger bandgap and intrinsically low thermal conductivity, which introduce an excellent carrier filtering effect to increase the Seebeck coefficient by 57.7% at 300 K without compromising electrical conductivity much and enhance phonon scattering to cause an ultralow lattice thermal conductivity of 1.39 W m−1 K−1 achieving amorphous limits of ZnO (1.4±0.1 W m−1 K−1). Consequently, a high peak ZT (figure of merit) of 0.691 at 873 K is obtained, which is higher than that of previously reported ZnO‐based TE materials. This work demonstrates a feasible and effective strategy to fabricate high‐performance TE materials, especially those with inferior electrical conductivity.
Rare‐Earth‐Free Mn30Fe20−xCuxAl50 Magnetocaloric Materials with Stable Cubic CsCl‐Type Structure for Room‐Temperature Refrigeration
Authors: Zhang Yikun , Hao Weixiang , Hu Chenglong , Wang Xing , Zhang Xuefeng , Li Lingwei 
Published: October 2023

AbstractMagnetic refrigeration technology based on the magnetocaloric effect (MCE) of magnetic substances has been considered a prominent, energy‐efficient, and environmentally benign cooling method. Exploring suitable magnetic substances is a prerequisite for practical applications. A family of rare‐earth‐free magnetocaloric materials called Mn30Fe20−xCuxAl50 alloys is identified room‐temperature refrigeration, which are derived from the well‐known MnAl‐based permanent magnets. As expected from experimental and theoretical investigations, all of the Mn30Fe20−xCuxAl50 alloys are crystallized in a stable cubic CsCl‐type crystal structure, revealing a single second‐order type magnetic phase transition (MPT) with tunable MPT temperature. They also exhibit a large reversible MCE and good magnetocaloric performances in a wide temperature range. Crucially, these Mn30Fe20−xCuxAl50 alloys represent a rare case of magnetic materials belonging to a large family that can be fabricated from low‐price, earth‐abundant, and non‐toxic elements. They could provide new choices for practical room‐temperature magnetic refrigeration applications.
Single‐Step Biofabrication of In Situ Spheroid‐Forming Compartmentalized Hydrogel for Clinical‐Sized Cartilage Tissue Formation
Authors: van Loo Bas , Schot Maik , Gurian Melvin , Kamperman Tom , Leijten Jeroen 
Published: October 2023

Abstract3D cellular spheroids offer more biomimetic microenvironments than conventional 2D cell culture technologies, which has proven value for many tissue engineering applications. Despite beneficiary effects of 3D cell culture, clinical translation of spheroid tissue engineering is challenged by limited scalability of current spheroid formation methods. Although recent adoption of droplet microfluidics can provide a continuous production process, use of oils and surfactants, generally low throughput, and requirement of additional biofabrication steps hinder clinical translation of spheroid culture. Here, the use of clean (e.g., oil‐free and surfactant‐free), ultra‐high throughput (e.g., 8.5 mL min−1, 10 000 spheroids s−1), single‐step, in‐air microfluidic biofabrication of spheroid forming compartmentalized hydrogels is reported. This novel technique can reliably produce 1D fibers, 2D planes, and 3D volumes compartmentalized hydrogel constructs, which each allows for distinct (an)isotropic orientation of hollow spheroid‐forming compartments. Spheroids produced within ink‐jet bioprinted compartmentalized hydrogels outperform 2D cell cultures in terms of chondrogenic behavior. Moreover, the cellular spheroids can be harvested from compartmentalized hydrogels and used to build shape‐stable centimeter‐sized biomaterial‐free living tissues in a bottom‐up manner. Consequently, it is anticipated that in‐air microfluidic production of spheroid‐forming compartmentalized hydrogels can advance production and use of cellular spheroids for various biomedical applications.
Multimodal Imaging‐Guided Photoimmunotherapy of Pancreatic Cancer by Organosilica Nanomedicine
Authors: Zhang Huifeng , Chen Kun , Guo Kai , Tao Jun , Song Lina , Ren Shuai , Zhao Yatong , Teng Zhaogang , Qiu Wenli , Wang Zhongqiu 
Published: October 2023

AbstractImmune checkpoint blockade (ICB) treatments have contributed to substantial clinical progress. However, challenges persist, including inefficient drug delivery and penetration into deep tumor areas, inadequate response to ICB treatments, and potential risk of inflammation due to over‐activation of immune cells and uncontrolled release of cytokines following immunotherapy. In response, this study, for the first time, presents a multimodal imaging‐guided organosilica nanomedicine (DCCGP) for photoimmunotherapy of pancreatic cancer. The novel DCCGP nanoplatform integrates fluorescence, magnetic resonance, and real‐time infrared photothermal imaging, thereby enhancing diagnostic precision and treatment efficacy for pancreatic cancer. In addition, the incorporated copper sulfide nanoparticles (CuS NPs) lead to improved tumor penetration and provide external regulation of immunotherapy via photothermal stimulation. The synergistic immunotherapy effect is realized through the photothermal behavior of CuS NPs, inducing immunogenic cell death and relieving the immunosuppressive tumor microenvironment. Coupling photothermal stimulation with αPD‐L1‐induced ICB, the platform amplifies the clearance efficiency of tumor cells, achieving an optimized synergistic photoimmunotherapy effect. This study offers a promising strategy for the clinical application of ICB‐based combined immunotherapy and presents valuable insights for applications of organosilica in precise tumor immunotherapy and theranostics.
Engineering Clinically Relevant Probiotics with Switchable “Nano‐Promoter” and “Nano‐Effector” for Precision Tumor Therapy
Authors: Cao Fangfang , Jin Lulu , Zhang Chenyin , Gao Yong , Qian Zhefeng , Wen Hongyang , Yang Sisi , Ye Ziqiang , Hong Liangjie , Yang Huang , Tong Zongrui , Cheng Liang , Ding Yuan , Wang Weilin , Yu Guocan , Mao Zhengwei , Chen Xiaoyuan 
Published: October 2023

AbstractProbiotics have the potential as biotherapeutic agents for cancer management in preclinical models and human trials by secreting antineoplastic or immunoregulatory agents in the tumor microenvironment (TME). However, current probiotics lack the ability to dynamically respond to unique TME characteristics, leading to limited therapeutic accuracy and efficacy. Although progress has been made in customizing controllable probiotics through synthetic biology, the engineering process is complex and the predictability of production is relatively low. To address this, here, for the first time, this work adopts pH‐dependent peroxidase‐like (POD‐like) artificial enzymes as both an inducible “nano‐promoter” and “nano‐effector” to engineer clinically relevant probiotics to achieve switchable control of probiotic therapy. The nanozyme initially serves as an inducible “nano‐promoter,” generating trace amounts of nonlethal reactive oxygen species (ROS) stress to upregulate acidic metabolites in probiotics. Once metabolites acidify the TME to a threshold, the nanozyme switches to a “nano‐effector,” producing a great deal of lethal ROS to fight cancer. This approach shows promise in subcutaneous, orthotopic, and colitis‐associated colorectal cancer tumors, offering a new methodology for modulating probiotic metabolism in a pathological environment.
Correlative Extinction and Single Fluorophore Bleaching Microscopy for Ligand Quantification on Gold Nanoparticles
Authors: Slesiona Nicole , Payne Lukas , Pope Iestyn , Borri Paola , Langbein Wolfgang , Watson Peter 
Published: October 2023

AbstractNanoparticles (NPs) are promising therapeutic delivery agents, with the number and manner of presentation of cell‐binding ligands on the NP affecting the eventual fate of the therapeutic. Whenever NPs are conjugated with biomolecules, a heterogeneous population of decorated NPs will be produced and these subpopulations of particle‐ligand structures need to be characterized for a reliable interpretation of NP‐based data. An optical microscopy method is reported to quantitatively evaluate the conjugation on a single‐particle basis in samples consisting of gold NPs (GNPs) decorated with holo‐transferrin fluorescently labeled with Alexa647 (Tf). Widefield fluorescence and extinction microscopy are employed on NP‐ligand constructs, alongside a correlative analysis that spatially co‐localizes diffraction‐limited sources of fluorescence with the optical extinction by individual GNPs. A photobleaching step analysis estimates the number of fluorophores contributing to the detected emission rate. The method quantifies the number of fluorescent biomolecules attached per GNP, the numbers of unconjugated GNPs and unbound Tf present within the mixed population, and the size and intraparticle clustering propensity of conjugated GNPs. A high variability is found in the number of Tf ligands per GNP within the GNP population, when analyzed at the single‐particle level, unraveling a non‐trivial statistical distribution not accessible in ensemble‐averaged approaches.