bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuolar proteomic analysis reveals tonoplast transporters for accumulation of citric acid and sugar in citrus fruit
Authors: Mao Zuolin , Wang Yue , Li Mengdi , Zhang Shuhang , Zhao Zeqi , Xu Qiang , Liu Ji-Hong , Li Chunlong 
Published: November 2023

Abstract
Vacuole largely dictates the fruit taste and flavor, as most of the sugars and organic acids are stored in the vacuoles of the fruit. However, difficulties associated with vacuole separation severely hinder identification and characterization of vacuolar proteins in fruit species. In this study, we established an effective approach for separating vacuoles and successfully purified vacuolar protein from six types of citrus fruit with varying patterns of sugar and organic acid contents. By using label-free LC–MS/MS proteomic analysis, 1443 core proteins were found to be associated with the essential functions of vacuole in citrus fruit. Correlation analysis of metabolite concentration with proteomic data revealed a transporter system for the accumulation of organic acid and soluble sugars in citrus. Furthermore, we characterized the physiological roles of selected key tonoplast transporters, ABCG15, Dict2.1, TMT2, and STP7 in the accumulation of citric acid and sugars. These findings provide a novel perspective and practical solution for investigating the transporters underlying the formation of citrus taste and flavor.
Semilinear optimal control with Dirac measures
Authors: Otárola Enrique 
Published: November 2023

Abstract
The purpose of this work is to study an optimal control problem for a semilinear elliptic partial differential equation with a linear combination of Dirac measures as a forcing term; the control variable corresponds to the amplitude of such singular sources. We analyze the existence of optimal solutions and derive first- and, necessary and sufficient, second-order optimality conditions. We develop a solution technique that discretizes the state and adjoint equations with continuous piecewise linear finite elements; the control variable is already discrete. We analyze the convergence properties of discretizations and obtain, in two dimensions, an a priori error estimate for the underlying approximation of an optimal control variable.
The Zoo of Opers and Dualities
Authors: Koroteev Peter , Zeitlin Anton M 
Published: November 2023

Abstract
We investigate various spaces of $SL(r+1)$-opers and their deformations. For each type of such opers, we study the quantum/classical duality, which relates quantum integrable spin chains with classical solvable many body systems. In this context, quantum/classical dualities serve as an interplay between two different coordinate systems on the space of opers. We also establish correspondences between the underlying oper spaces, which recently had multiple incarnations in symplectic duality and bispectral duality.
Current diagnosis and treatment of salivary gland-type tumors of the lung
Authors: Horio Yoshitsugu , Kuroda Hiroaki , Masago Katsuhiro , Matsushita Hirokazu , Sasaki Eiichi , Fujiwara Yutaka 
Published: November 2023

AbstractSalivary gland-type tumors of the lung are thought to originate from the submucosal exocrine glands of the large airways. Due to their rare occurrence, reports of their study are limited to small-scale or case reports. Therefore, daily clinical practices often require a search for previous reports. In the last 20 years, several genetic rearrangements have been identified, such as MYB::NF1B rearrangements in adenoid cystic carcinoma, CRTC1::MAML2 rearrangements in mucoepidermoid carcinoma, EWSR1::ATF1 rearrangements in hyalinizing clear cell carcinoma and rearrangements of the EWSR1 locus or FUS (TLS) locus in myoepithelioma and myoepithelial carcinoma. These molecular alterations have been useful in diagnosing these tumors, although they have not yet been linked to molecularly targeted therapies. The morphologic, immunophenotypic, and molecular characteristics of these tumors are similar to those of their counterparts of extrapulmonary origin, so clinical and radiologic differential diagnosis is required to distinguish between primary and metastatic disease of other primary sites. However, these molecular alterations can be useful in differentiating them from other primary lung cancer histologic types. The management of these tumors requires broad knowledge of the latest diagnostics, surgery, radiotherapy, bronchoscopic interventions, chemotherapy, immunotherapy as well as therapeutic agents in development, including molecularly targeted agents. This review provides a comprehensive overview of the current diagnosis and treatment of pulmonary salivary gland tumors, with a focus on adenoid cystic carcinoma and mucoepidermoid carcinoma, which are the two most common subtypes.
Comprehensive X-ray and multiwavelength study of ULXs in NGC 1566
Authors: Allak Sinan 
Published: November 2023

ABSTRACT
This paper presents a comprehensive X-ray and multiwavelength study of ultraluminous X-ray sources (ULXs) in NGC 1566 using archival Chandra, Swift/XRT, JWST, and HST observations. The main results are, first, from the hardness ratio diagram, where spectral state transitions from hard to soft as seen in typical Galactic high-mass X-ray binaries for ULX-3 were observed. Secondly, a new transient ULX candidate (ULX-4) was identified, reaching a peak luminosity of ∼1040 erg s−1. Thirdly, the optical and NIR (near-infrared) counterparts of the ULXs were searched from the precise astrometric calculations. For ULX-1 and ULX-2, evidence was found that the observed NIR emission is due to the circumbinary disc/dust disrupted by X-rays. Lastly, the optical observations suggest that the possible donor star of ULX-3 is a B-type supergiant. In the case of ULX-4, the multiwavelength properties are not clear since many sources are detected within the astrometric error radius.
Revised ephemeris and orbital period derivative of the supersoft X-ray source CAL 87 based on 34 yr of observations
Authors: Stecchini P E , Jablonski F , Diaz M P , D’Amico F , Oliveira A S , Palivanas N , Saito R K 
Published: November 2023

ABSTRACT
In this study, we present an analysis of over 34 yr of observational data from CAL 87, an eclipsing supersoft X-ray source. The primary aim of our study, which combines previously analysed measurements as well as unexplored publicly available data sets, is to examine the orbital period evolution of CAL 87. After meticulously and consistently determining the eclipse timings, we constructed an O − C (observed minus calculated) diagram using a total of 38 data points. Our results provide confirmation of a positive derivative in the system’s orbital period, with a determined value of $\dot{P}=+\, 8.18\pm 1.46\times 10^{-11}$ s s−1. We observe a noticeable jitter in the eclipse timings and additionally identify a systematic delay in the X-ray eclipses compared to those observed in longer wavelengths. We discuss the interplay of the pertinent factors that could contribute to a positive period derivative and the inherent variability in the eclipses.
The centroid speed as a characteristic of the group speed of solar coronal fast magnetoacoustic wave trains
Authors: Kolotkov Dmitrii Y , Nakariakov Valery M , Cloesen Maximilien 
Published: November 2023

ABSTRACT
The highly filamented nature of the coronal plasma significantly influences dynamic processes in the corona such as magnetohydrodynamic waves and oscillations. Fast magnetoacoustic waves, guided by coronal plasma non-uniformities, exhibit strong geometric dispersion, forming quasi-periodic fast-propagating (QFP) wave trains. QFP wave trains are observed in extreme-ultraviolet imaging data and indirectly in microwaves and low-frequency radio, aiding in understanding the magnetic connectivity, energy, and mass transport in the corona. However, measuring the field-aligned group speed of QFP wave trains, as a key parameter for seismological analysis, is challenging due to strong dispersion and associated rapid evolution of the wave train envelope. We demonstrate that the group speed of QFP wave trains formed in plane low-β coronal plasma non-uniformities can be assessed through the propagation of the wave train’s effective centre of mass, referred to as the wave train’s centroid speed. This centroid speed, as a potential observable, is shown empirically to correspond to the group speed of the most energetic Fourier harmonic in the wave train. The centroid speed is found to be almost insensitive to the waveguide density contrast with the ambient corona, and to vary with the steepness of the transverse density profile. The discrepancy between the centroid speed as the group speed measure and the phase speed at the corresponding wavelength is shown to reach 70 per cent, which is crucial for the energy flux estimation and interpretation of observations.
Unravelling the dust attenuation scaling relations and their evolution
Authors: Maheson Gabriel , Maiolino Roberto , Curti Mirko , Sanders Ryan , Tacchella Sandro , Sandles Lester 
Published: November 2023

ABSTRACT
We explore the dependence of dust attenuation, as traced by the $\rm H_{\alpha }/\rm H_{\beta }$ Balmer decrement, on galactic properties by using a large sample of Sloan Digital Sky Survey spectra. We use both partial correlation coefficients and random forest analysis to distinguish those galactic parameters that directly and primarily drive dust attenuation in galaxies, from parameters that are only indirectly correlated through secondary dependencies. We find that, once galactic inclination is controlled for, dust attenuation depends primarily on stellar mass, followed by metallicity and velocity dispersion. Once the dependence on these quantities is taken into account, there is no dependence on the star formation rate. While the dependence on stellar mass and metallicity was expected based on simple analytical equations for the interstellar medium, the dependence on velocity dispersion was not predicted, and we discuss possible scenarios to explain it. We identify a projection of this multidimensional parameters space which minimizes the dispersion in terms of the Balmer decrement and which encapsulates the primary and secondary dependences of the Balmer decrement into a single parameter defined as the reduced mass μ = log M⋆ + 3.67[O/H] + 2.96log (σv/100 km s−1). We show that the dependence of the Balmer decrement on this single parameter also holds at high redshift, suggesting that the processes regulating dust production and distribution do not change significantly through cosmic epochs at least out to z ∼ 2.
The intrinsic X-ray luminosity distribution of an optically selected SDSS quasar population
Authors: Rankine Amy L , Aird James , Ruiz Angel , Georgakakis Antonis 
Published: November 2023

ABSTRACT
In active galactic nuclei, the relationship between UV and X-ray luminosity is well studied (often characterised by αox) but often with heterogeneous samples. We have parametrized the intrinsic distribution of X-ray luminosity, LX, for the optically selected sample of SDSS quasars in the Stripe 82 and XXL fields across redshifts 0.5–3.5. We make use of the available XMM observations and a custom pipeline to produce Bayesian sensitivity curves that are used to derive the intrinsic X-ray distribution in a hierarchical Bayesian framework. We find that the X-ray luminosity distribution is well described by a Gaussian function in log10 LX space with a mean that is dependent on the monochromatic 2500 Å UV luminosity, L2500. We also observe some redshift dependence of the distribution. The mean of the LX distribution increases with redshift while the width decreases. This weak but significant redshift dependence leads to L2500–LX and L2500–αox relations that evolve with redshift, and we produce a redshift- and L2500-dependent αox equation. Neither black hole mass nor Eddington ratio appear to be potential drivers of the redshift evolution.
Modelling the spectra of the kilonova AT2017gfo – II. Beyond the photospheric epochs
Authors: Gillanders J H , Sim S A , Smartt S J , Goriely S , Bauswein A 
Published: November 2023

ABSTRACT
Binary neutron star mergers are the first confirmed site of element nucleosynthesis by the rapid neutron-capture process (r-process). The kilonova AT2017gfo is the only electromagnetic counterpart of a neutron star merger spectroscopically observed. We analyse the entire spectral sequence of AT2017gfo (from merger to +10.4 d) and identify seven emission-like features. We confirm that the prominent 1.08 $\mu{\text{m}}$ feature can be explained by the Sr ii near-infrared triplet evolving from a P-Cygni profile through to pure emission. We calculate the expected strength of the [Sr ii] doublet and show that its absence requires highly clumped ejecta. Near-infrared features at 1.58 and 2.07 $\mu {\text{m}}$ emerge after three days and become more prominent as the spectra evolve. We model these as optically thick P-Cygni profiles and alternatively as pure emission features (with FWHM ≃ 35 600 ± 6600 km s−1) and favour the latter interpretation. The profile of the strong 2.07 $\mu {\text{m}}$ emission feature is best reproduced with two lines, centred at 2.059 and 2.135 $\mu {\text{m}}$. We search for candidate ions for all prominent features in the spectra. Strong, permitted transitions of La iii, Ce iii, Gd iii, Ra ii, and Ac i are plausible candidates for the emission features. If any of these features are produced by intrinsically weak, forbidden transitions, we highlight candidate ions spanning the three r-process peaks. The second r-process peak elements Te and I have plausible matches to multiple features. We highlight the need for more detailed and quantitative atomic line transition data.
Photoevaporation obfuscates the distinction between wind and viscous angular momentum transport in protoplanetary discs
Authors: Coleman Gavin A L , Mroueh Joseph K , Haworth Thomas J 
Published: November 2023

ABSTRACT
How protoplanetary discs evolve remains an unanswered question. Competing theories of viscosity and magnetohydrodynamic disc winds have been put forward as the drivers of angular momentum transport in protoplanetary discs. These two models predict distinct differences in the disc mass, radius, and accretion rates over time, that could be used to distinguish them. However that expectation is built on models that do not include another important process – photoevaporation, both internally by the host star and externally by neighbouring stars. In this work we produce numerical models of protoplanetary discs including viscosity, magnetohydrodynamic disc winds, and internal and external photoevaporation. We find that even weak levels of external photoevaporation can significantly affect the evolution of protoplanetary discs, influencing the observable features such as disc radii, that might otherwise distinguish between viscous and wind driven discs. Including internal photoevaporation further suppresses differences in evolution between viscous and wind driven discs. This makes it much more difficult than previously anticipated, to use observations of nearby star forming regions to determine whether discs are viscous or wind driven. Interestingly we find that evolved protoplanetary discs in intermediate FUV environments may be the best cases for differentiating whether they evolve through viscosity or magnetohydrodynamic disc winds. Ultimately this work demonstrates the importance of understanding what are the key evolutionary processes and including as many of those as possible when exploring the evolution of protoplanetary discs.
Narrow absorption line outflow in Seyfert 1 galaxy J1429+4518: outflow’s distance from the central source and its energetics
Authors: Dehghanian M , Arav N , Byun D , Walker G , Sharma M 
Published: November 2023

ABSTRACT
In the Hubble Space Telescope/Cosmic Origins Spectrograph spectrum of the Seyfert 1 galaxy 2MASX J14292507+4518318, we have identified a narrow absorption line outflow system with a velocity of −151 km s−1. This outflow exhibits absorption troughs from the resonance states of ions like C iv, N v, S iv, and Si ii, as well as excited states from C ii* and Si ii*. Our investigation of the outflow involved measuring ionic column densities and conducting photoionization analysis. These allow the total column density of the outflow to be estimated as log NH = 19.84 cm−2, its ionization parameter to be log UH = −2.0, and its electron number density to be log ne = 2.75 cm−3. These measurements enabled us to determine the mass-loss rate and the kinetic luminosity of the outflow system to be $\dot{M}$ = 0.22 $\mathrm{ M}_{\odot } \, \mathrm{ yr}^{-1}$ and $\log \dot{E_{\mathrm{ K}}}$ = 39.3 erg s−1, respectively. We have also measured the location of the outflow system to be at ∼275 pc from the central source. This outflow does not contribute to the active galactic nucleus (AGN) feedback processes due to the low ratio of the outflow’s kinetic luminosity to the AGN’s Eddington luminosity ($\dot{E_{\mathrm{ K}}}/{L_{\mathrm{ Edd}}}\approx 0.00025 {{\, \rm per\, cent}}$). This outflow is remarkably similar to the two bipolar lobe outflows observed in the Milky Way by XMM–Newton and Chandra.
Mental health and addiction service utilization among people living with chronic kidney disease
Authors: Bhasin Arrti A , Molnar Amber O , McArthur Eric , Nash Danielle M , Busse Jason W , Cooper Rebecca , Heale Esti , Ip Jane , Pang Jocelyn , Blake Peter G , Garg Amit X , Kurdyak Paul , Kim S Joseph , Sultan Heebah , Walsh Michael 
Published: November 2023

ABSTRACT

Background
Mental health problems, particularly anxiety and depression, are common in patients with chronic kidney disease (CKD) and negatively impact quality of life, treatment adherence and mortality. However, the degree to which mental health and addiction services are utilized by those with CKD is unknown. We examined the history of mental health and addiction service use of individuals across levels of kidney function.

Methods
We performed a population-based cross-sectional study using linked healthcare databases from Ontario, Canada from 2009 to 2017. We abstracted the prevalence of individuals with mental health and addiction service use within the previous 3 years across levels of kidney function [estimated glomerular filtration rate (eGFR) ≥60, 45 to &lt;60, 30 to &lt;45, 15 to &lt;30, &lt;15 ml/min/1.73 m2 and maintenance dialysis]. We calculated prevalence ratios (PRs) to compare prevalence across kidney function strata, while adjusting for age, sex, year of cohort entry, urban versus rural location, area-level marginalization and Charlson comorbidity index.

Results
Of 5 956 589 adults, 9% (n = 534 605) had an eGFR &lt;60 ml/min/1.73 m2 or were receiving maintenance dialysis. Fewer individuals with an eGFR &lt;60 ml/min/1.73 m2 had a history of any mental health and addiction service utilization (crude prevalence range 28–31%) compared with individuals with an eGFR ≥60 ml/min/1.73 m2 (35%). Compared with an eGFR ≥60 ml/min/1.73 m2, the lowest prevalence of individuals with any mental health and addiction service utilization was among those with an eGFR of 15 to &lt;30 ml/min/1.73 m2 {adjusted PR 0.86 [95% confidence interval (CI) 0.85 to 0.88]}, an eGFR &lt;15 ml/min/1.73 m2 [adjusted PR 0.81 (95% CI 0.76–0.86)] and those receiving maintenance dialysis [adjusted PR 0.83 (95% CI 0.81–0.84)]. Less use of outpatient services accounted for differences in service utilization.

Conclusions
Mental health and addiction service utilization is common but less so in individuals with advanced CKD in Ontario, Canada.
An Automated Virtual Reality Program Accurately Diagnoses HIV-Associated Neurocognitive Disorders in Older People With HIV
Authors: Moore Raeanne C , Kuehn Kevin S , Heaton Anne , Sundermann Erin E , Campbell Laura M , Torre Peter , Umlauf Anya , Moore David J , Kosoris Nicole , Wright David W , LaPlaca Michelle C , Waldrop Drenna , Anderson Albert M 
Published: November 2023

Abstract

Background
HIV-associated neurocognitive disorders (HANDs) remain prevalent despite antiretroviral therapy, particularly among older people with HIV (PWH). However, the diagnosis of HAND is labor intensive and requires expertise to administer neuropsychological tests. Our prior pilot work established the feasibility and accuracy of a computerized self-administered virtual reality program (DETECT; Display Enhanced Testing for Cognitive Impairment and Traumatic Brain Injury) to measure cognition in younger PWH. The present study expands this to a larger sample of older PWH.

Methods
We enrolled PWH who were ≥60 years old, were undergoing antiretroviral therapy, had undetectable plasma viral loads, and were without significant neuropsychological confounds. HAND status was determined via Frascati criteria. Regression models that controlled for demographic differences (age, sex, education, race/ethnicity) examined the association between DETECT's cognition module and both HAND status and Global Deficit Score (GDS) derived via traditional neuropsychological tests.

Results
Seventy-nine PWH (mean age, 66 years; 28% women) completed a comprehensive neuropsychological battery and DETECT's cognition module. Twenty-five (32%) had HAND based on the comprehensive battery. A significant correlation was found between the DETECT cognition module and the neuropsychological battery (r = 0.45, P &lt; .001). Furthermore, in two separate regression models, HAND status (b = −0.79, P &lt; .001) and GDS impairment status (b = −0.83, P &lt; .001) significantly predicted DETECT performance. Areas under the curve for DETECT were 0.78 for differentiating participants by HAND status (HAND vs no HAND) and 0.85 for detecting GDS impairment.

Conclusions
The DETECT cognition module provides a novel means to identify cognitive impairment in older PWH. As DETECT is fully immersive and self-administered, this virtual reality tool holds promise as a scalable cognitive screening battery.
Epidermolysis bullosa in a mother-infant dyad
Authors: Prashanth R R , Kamble Pramod Dhanraj , Kumari Abhilasha , Haribalakrishna Anitha , Mahajan Sunanda Arun 
Published: November 2023

Abstract
Epidermolysis Bullosa is an inherited mechanobullous disorder which presents in the neonatal period as blistering skin lesions. In this case report, we describe an uncommon presentation of Epidermolysis Bullosa Simplex in a term infant, weighing 2640 g, born to a mother who was also diagnosed with Epidermolysis Bullosa Pruriginosa during the course of the evaluation of her newborn. The clinical situation presented us with a unique dilemma with regard to routine newborn care practices including handling, skin and diaper care. Though the presentation was typically characteristic of EB, we illustrate with images the diagnostic modalities and challenges faced in the hospital while caring for this fragile skin in a low and middle-income country’s neonatal intensive care unit. This is the first reported case of a neonate with Epidermolysis Bullosa Simplex born to a mother with Epidermolysis Bullosa Pruriginosa.