bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological lessons for strategic resistance management
Authors: Blumstein Daniel T. , Johnson Norman A. , Katz Nurit D. , Kharpatin Samuel , Ortiz‐Ross Xochitl , Parra Eliseo , Reshke Amanda 
Published: November 2023

AbstractBiological resistance to pesticides, vaccines, antibiotics, and chemotherapies creates huge costs to society, including extensive morbidity and mortality. We simultaneously face costly resistance to social changes, such as those required to resolve human–wildlife conflicts and conserve biodiversity and the biosphere. Viewing resistance as a force that impedes change from one state to another, we suggest that an analysis of biological resistance can provide unique and potentially testable insights into understanding resistance to social changes. We review key insights from managing biological resistance and develop a framework that identifies seven strategies to overcome resistance. We apply this framework to consider how it might be used to understand social resistance and generate potentially novel hypotheses that may be useful to both enhance the development of strategies to manage resistance and modulate change in socio‐ecological systems.
Complications of orotracheal intubation in the horse
Authors: Burns Patrick M. 
Published: November 2023

SummaryDifficulty to extubate any patient is not a problem commonly thought of during general anaesthesia. This case report describes some of the factors that lead to this predicament and the successful surgical removal of the endotracheal tube via a tracheostomy. This case report also highlights some of the deficiencies in the clinical practice of veterinary anaesthesia. Further research is required for the selection size criteria of endotracheal tubes in all species and the monitoring of cuff pressures during general anaesthesia.
Toothbrushing‐induced vestibular ulcerations with severe gingival defects
Authors: Liu Beili , Cao Jie , Lu Weiqing , Yao Hui 
Published: November 2023

BackgroundDaily toothbrushing is a routine approach for helping to keep the oral cavity healthy. However, using a toothbrush as an ordinary oral hygiene habit can also lead to adverse events.Case PresentationA 75‐year‐old man was referred by a periodontist for vestibular ulcerations with gingival defects. The patient reported no significant medical or social history, which might be associated with his symptoms. On examination, wide labio‐buccal gingival defects, white attached gingiva and linear vestibular ulcerations were observed. With the help of the periodontist, a diagnosis of inappropriate toothbrushing‐induced traumatic ulcerations was reasoned via an approach of aetiological elimination. The patient was put on a trial course of topical dexamethasone powder with lincomycin. The resolution of vestibular ulcerations was apparent after two weeks. He reported no similar oral ulcerations during the following nine years.ConclusionTo our knowledge, this is the first case reported in the literature of vestibular ulcerations with severe gingival defects caused by inappropriate toothbrushing. The establishment of a correct diagnosis needs a close collaboration between periodontists and oral medicine specialists. Instruction on correct toothbrushing, especially for older people can be beneficial.
IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro
Authors: Chansaenroj Ajjima , Kornsuthisopon Chatvadee , Suwittayarak Ravipha , Rochanavibhata Sunisa , Loi Lai‐Keng , Lin Yu‐Cheng , Osathanon Thanaphum 
Published: November 2023

AbstractAimTo investigate the effect of IWP‐2, Wnt inhibitor, on human dental pulp stem cells (hDPSCs) responses.MethodologyhDPSCs were isolated from human dental pulp tissues. Cells were treated with 25 μM IWP‐2 for 24 h, and subsequently, the gene expression profile was examined using high‐throughput RNA sequencing. The mRNA expression was analysed using qPCR. The effect of IWP‐2 was investigated in both normal and LPS‐induced hDPSCs (inflamed hDPSCs). CD4+ T cells and CD14+ monocyte‐derived macrophages were cultured with conditioned media of IWP‐2 treated hDPSCs to observe the immunosuppressive property.ResultsRNA sequencing indicated that IWP‐2 significantly downregulated several KEGG pathways, including cytokine‐cytokine receptor interaction, IL‐17 signalling pathway, and TNF signalling pathway. In both normal and inflamed conditions, IWP‐2 markedly upregulated TGFB1 mRNA expression while the mRNA expression of pro‐inflammatory cytokines, TNFA, IL1B, IFNG, and IL6, was inhibited. In the inhibition experiment, the pretreatment with p38, MAPK, or PI3K inhibitors abolished the effects of IWP‐2 in LPS‐induced inflammation. In terms of immune cells, IWP‐2‐treated‐inflamed hDPSCs conditioned media attenuated T cell proliferation and regulated regulatory T cell differentiation. In addition, the migratory property of macrophage was decreased after being exposed to IWP‐2‐treated inflamed hDPSCs conditioned media.ConclusionIWP‐2 suppressed inflammatory cytokine expression in both normal and inflamed hDPSCs. Moreover, hDPSCs exerted the immunosuppressive property after IWP‐2 treatment. These results suggest the role of Wnt in inflammatory responses and immunomodulation in dental pulp tissues.
Exploring effect of M2 macrophages on experimental full‐thickness wound healing in streptozotocin‐induced diabetic rats
Authors: Khoshnoudi Parmis , Sabiza Soroush , Khosravi Mohammad , Mohamadian Babak 
Published: November 2023

AbstractDiabetes mellitus is one of the most prevalent medical conditions, in both humans and animals. People with diabetes mellitus often experience slower than normal wound healing, making it a serious health concern. This study investigates the effect of M2 differentiated macrophages on full‐thickness wound healing in white Westar rats exposed to streptozocin 70 mg/kg. A full‐thickness skin defect with dimensions of 2 × 2 cm was created on the back of all the animals, and their blood sugar was simultaneously assessed. The monocytes were isolated from blood samples using the plastic adherence method and were exposed to dexamethasone (5–10 μ) for 24 h. Subsequently, they were washed with PBS and incubated in fresh cell culture medium for 5 days. The differentiated M2 cells were injected into four points of the experimental ulcers of the treatment group. Macroscopic and microscopic changes were evaluated and compared over a period of two weeks between the test and control groups. The infusion of these cells a few days after wounding enhances wound healing parameters significantly, as evidenced by an increase in germinating tissue formation, wound contraction, inflammation reduction, and collagen increase in the treated group.
Mapping sustainability practices in the healthcare sector: A systematic literature review and future research agenda
Authors: Rahat Nazish , Sahni Shalini , Nasim Saboohi 
Published: November 2023

AbstractSustainable healthcare means providing affordable, quality medical care without causing undue environmental damage, which is critical for a world just emerging from a debilitating pandemic. This article contends that it is now an opportune time to map the existing knowledge to guide future sustainability research in healthcare. Therefore, this article aims to systematically review and comprehensively analyse the extant literature on sustainability practices in healthcare organizations and propose future research directions based on gaps in the literature. A corpus of 79 articles sourced from five databases and published between 1995 and 2022 was identified for an in‐depth review. Following a framework‐based systematic literature review, this article offers an organized, retrospective view of the performance using antecedents, decisions, and outcomes (ADO) and Theories–Contexts–Methods (TCM) integrated framework. These frameworks are used to evaluate and understand sustainability practices in the healthcare sector. Additionally, the article shows the thematic evolution of sustainability research in healthcare with the help of five clusters. While the systematic literature review results highlight the large theoretical base, it also reveals the lack of consensus on defining sustainability. The analysis of 79 articles yielded six valuable categories of antecedents with 27 constructs, five categories of decisions with 11 constructs, and two categories of outcomes with 15 constructs. Results also reveal a lack of consensus regarding the influence of sustainability practices on organizational performance across the three sustainability pillars (social, environmental, and economic dimensions). The present review has implications for healthcare service delivery systems and policymakers to help them redesign their services to promote sustainable development goals. Before concluding the article, knowledge gaps and future research directions are structured using the ADO‐TCM framework through pertinent ideas for sustainability research in healthcare organizations.
Striae distensae treatment: evaluating laser efficacy and safety
Authors: Menashe Shaked , Heller Lior 
Published: November 2023

AbstractBackgroundStriae distensae (SD) are common skin lesions that are difficult to treat and affect quality of life. Laser and light are emerging non‐invasive therapies that have proven successful in treating SD. Recently, hybrid laser devices offering simultaneous fractional ablative and non‐ablative laser treatment have been reported to benefit various skin conditions.ObjectiveTo evaluate the improvement of SD treated with a hybrid laser system and to analyze associations with patient characteristics.MethodsWe performed a retrospective study in which 28 adults with SD were treated with a hybrid laser device. Efficacy was evaluated by the assessment of aesthetic improvement by the Global Aesthetic Improvement Scale (GAIS) of 1–10 and by patients' satisfaction using a scale of 0–10 satisfaction scale. Pain and adverse events were monitored. Statistical analysis was used to examine the potential impact of various factors on treatment outcomes.ResultsThe mean GAIS score was 7.36 ± 1.06 with a positive correlation with patient satisfaction (r = 0.685) and a weak negative correlation with patient age (r = −0.0057). Skin type and body area did not show significant associations with GAIS scores (P > 0.05 for both). No adverse events were observed.ConclusionThis study demonstrates the potential of the hybrid laser system as a safe and effective method to achieve satisfactory aesthetic results with minimal downtime, making it a promising treatment approach for SD. Treatment outcomes were independent of patient characteristics, further supporting its widespread use.
Urinary markers for bladder cancer diagnosis: A review of current status and future challenges
Authors: Tomiyama Eisuke , Fujita Kazutoshi , Hashimoto Mamoru , Uemura Hirotsugu , Nonomura Norio 
Published: November 2023

AbstractBladder cancer is a common urological cancer with a high recurrence rate that requires long‐term follow‐up, and early detection positively affects prognosis. To date, the initial diagnosis and follow‐up for bladder cancer rely on cystoscopy, which is an invasive and expensive procedure. Therefore, urinary markers for the detection of bladder cancer have attracted research attention for decades to reduce unnecessary cystoscopies. Urine, which is in continuous contact with bladder cancer, is considered a suitable fluid for providing tumor information. Urinary cytology is the only widely used urinary marker in clinical practice; however, it has poor sensitivity for low‐grade tumors; indicating the need for novel urinary markers. Considerable research has been conducted on this topic over the years, resulting in a complex landscape with a wide range of urinary markers, including protein‐, exfoliated cell‐, RNA‐, DNA‐, and extracellular vesicle‐based markers. Although some of these markers have been approved by the U.S. Food and Drug Administration and are commercially available, their use in clinical practice is limited. To facilitate clinical application, potential urinary markers must withstand prospective clinical trials and be easy for patients and clinicians to understand and utilize in a clinical context. This review provides a comprehensive overview of currently available and recently reported promising urinary markers for bladder cancer. Additionally, the challenges and the prospects of these urinary markers for clinical implementation in bladder cancer treatment were discussed.
Change and stability of migration intentions. Evidence from Italy
Authors: Barbiano di Belgiojoso Elisa , Bonifazi Corrado , Ortensi Livia Elisa , Paparusso Angela 
Published: November 2023

AbstractDue to a lack of relevant data, very few empirical studies have examined the changes in and stability of secondary migration intentions. We aim to fill this gap by analysing return migration intentions among international migrants in Italy. Data are drawn from the cross‐sectional SCIF survey conducted by ISTAT in 2011–2012. Our findings reveal that migration intentions at the beginning of the migratory experience tend to differ from those measured at more advanced migration stages (i.e. at the time of the survey). In particular, intentions to return seem less stable than intentions to stay. When confirming intentions to return or remain, critical factors include financial stability, family situation and ties with the country of origin and destination. Additionally, having an Italian partner, a partner living in Italy, and a positive self‐assessed family financial condition are positively associated with transitioning from a temporary plan to a permanent settlement intention.
September 2002: 24‐year‐old female with a 6‐month history of seizures
Authors: Lamszus Katrin , Makrigeorgi‐Butera Maria , Laas Rudolf , West‐Phal Manfred , Stavrou Dimitrios 
Published: November 2023

AbstractCases of the Month, July to September, 2002The July 2002 Case of the Month (COM). This 66‐year‐old Caucasian female presented with gradually increasing protrusion of her left eye over a one‐year period. She complained of increased tearing and foreign body sensation. The physical examination revealed a visual acuity of 20/20, normal color testing, full vision field with motility of her left eye limited in lateral gaze. Pupils were round, symmetric, with no afferent pupillary defect noted. On external examination, her left eye was grossly proptotic with resistance to retropulsion. She had 4 mm proptosis of the left eye. Computed tomography and MR imaging demonstrated a left retro‐orbital mass with gadolinium enhancement and focal remodeling of orbital bones. She underwent surgical resection of tumor with a diagnosis of solitary fibrous tumor, and postoperatively she was symptom free. The histopathological differential diagnoses of spindle cell neoplasms of the orbit are discussed. Five months after surgery, no evidence of tumor recurrence was seen on neuroimaging and her vision was 20/20.The August 2002 COM. A 21‐year‐old male presented with a single episode of generalized tonic clonic seizures. Radiology revealed a cystic tumor with mural nodule suggestive of a pilocytic astrocytoma. However, histopathological examination and electron microscopy revealed features of an intracerebral schwannoma. Therefore, although rare, in an intracerebral cystic lesion with mural nodule, the possibility of an intracerebral schwannoma should be entertained. This is important because this is a benign tumor with favourable response to resection.The September 2002 COM. A 24‐year‐old female presented with a history of 3 generalized seizures, the first of which had occurred 6 months before admission. Her neurological examination was normal, but upon admission her MRI showed a small cystic lesion in the left parieto‐occipital region. The lesion was hyper‐intense on T‐2 weighted images and did not show contrast enhancment. At surgery, the tumor was found to be deep to the cortex and was a cyst with amber fluid surrounded by gliotic brain. Microscopically, the tumor was well‐demarcated from the surrounding tissues, which showed reactive changes, including Rosenthal fibers. The tumor was composed of GFAP‐positive glial cells, which were arranged in a pseudopapillary fashion around blood vessels. In between, the tumor cells were positive for neuronal markers. The diagnosis was papillary glioneuronal tumor (PGNT), a relatively recently described lesion that may be a variant of ganglioglioma. The current literature on PGNTs is reviewed.
Measurements of stresses in β‐(Y,Yb)2Si2O7 environmental barrier coating layers using Raman spectroscopy
Authors: Setlur Anant A. , Davis Robert J. , Johnson Curtis A. , Sarrafi‐Nour Reza 
Published: November 2023

AbstractResidual stress measurements in environmental barrier coatings (EBCs) can help in understanding coating durability and potential damage mechanisms. We demonstrate the capability of Raman spectroscopy to measure average residual stresses in two different β‐RE2Si2O7 (RE = rare earth or Y3+, denoted as REDS) EBCs with a nominal (Yb,Y)2Si2O7 composition, focusing on macroscopic residual stresses acting at macroscopic length scales. Uniaxial compression measurements of dense β‐(Yb,Y)2Si2O7 ceramics are used for calibration curves for applied stress versus Raman peak shift. We use these calibration curves to evaluate the macroscopic thermoelastic residual stress in the (Yb,Y)2Si2O7 layers from coefficient of thermal expansion (CTE) mismatch of two different (Yb,Y)2Si2O7‐based EBCs on SiC‐based substrates. Microscopic stress contributions to Raman peak shifts are subtracted using reference free‐standing coatings and analytic estimates for inclusion stresses when (Yb,Y)2Si2O7 coatings have a high, variable volume fraction of (Yb,Y)2SiO5. The macroscopic thermal residual stress in these (Yb,Y)2Si2O7 EBCs is compressive, as expected from the smaller CTE of β‐REDS versus SiC. These thermal residual stresses can vary between different YbYDS EBC coatings by more than a factor of three with a measured layer residual stress of approximately –180 MPa (compressive) for a high modulus, low CTE coating, and our measured values generally agree with calculated estimates.
Larger distribution ranges of seagrasses towards the equator
Authors: Tuya Fernando , Bosch Néstor E. , Rodríguez Laura 
Published: November 2023

AbstractAimThe description of species' ranges provides biogeographical information to explain fundamental macroecological and evolutionary processes. In this study, we investigated the Rapoport's rule for the world's seagrasses, that is, whether the range extent of seagrasses increases from the tropics to the poles.LocationGlobal.TaxonSeagrasses.MethodsWe examined whether four range geographical metrics: the extent of latitudinal and longitudinal ranges, total distribution area (Km2) and the number of marine ecoregions encompassed by seagrass species, changed according to their latitudinal distribution midpoints.ResultsSeagrasses have larger distribution ranges, as indicated by all geographical metrics, close to the equator in both hemispheres, supporting the inverse of the Rapoport's biogeographical pattern.Main ConclusionsThe larger distribution ranges of seagrasses towards equatorial regions may be attributed to their origins during warm geologic periods, and the subsequent longer climatic stability in tropical areas leading to climate niche conservatism constraining seagrass evolution.
Equal Focus on Inequality? Approaches to Distributional Impact Assessment in the National Budget Process Across the EU
Authors: Bazoli Nicola , Fiorio Carlo , Marzadro Sonia , Pycroft Jonathan , Vergolini Loris 
Published: November 2023

AbstractAfter four decades of increasing within‐country income inequality in many EU Member States, this study first aims to understand to what extent and how EU Member States make use of distributional impact assessments (DIAs) for budgetary measures. The second aim is to understand the factors that constrain the use of DIA, leading us to propose strategies for how it could be used more widely. To these ends, we perform a desk‐based study of the documents produced in the national budgeting process, which is then followed up with structured key informant interviews with those responsible for producing key budgetary documents in each of the 27 Member States of the EU. We then detail the constraints to performing more DIAs and potential solutions involving actions at both the country and EU levels. This study constitutes the first comprehensive analysis of DIA practices across the EU.
Mechanisms of the Effect of Individual Education on Pro‐European Dispositions
Authors: Fernández Juan J. , Teney Céline , Díez Medrano Juan 
Published: November 2023

AbstractA burgeoning empirical literature on attitudes towards Europe shows that highly educated individuals are more likely to hold pro‐European dispositions than non‐highly educated individuals. The literature provides structural and cultural accounts for this relationship. The structural account highlights that formal education contributes to earning higher incomes and attaining an upper‐class occupation, which are conducive to pro‐European dispositions. The cultural account instead highlights that formal education instils universalist and non‐traditionalist values in individuals, which are conducive to pro‐European dispositions. This is the first article to assess the relative predictive power of these two approaches. Using structural equation models, Rounds 8–10 of the European Social Survey and three indicators of pro‐European dispositions, this article examines whether socio‐economic location measured by income and upper‐class occupation or commitment to human values measured by universalism and traditionalism mediates this association. All in all, the structural approach receives stronger support than the cultural one.
Cryoprotective effect of soybean oil on surimi gels and the mechanism based on molecular dynamics simulation
Authors: Shen Zhiwen , Gao Huaqian , Peng Wanqi , Wang Faxiang , Liu Yongle , Wu Jinhong , Wang Shaoyun , Li Xianghong 
Published: November 2023

AbstractThe effect of soybean oil (SO) on freeze‐thaw (F‐T)‐treated surimi was investigated and its related mechanism was revealed by molecular dynamics (MD) simulations. The results displayed that SO has a disrupting effect on the structure of fresh samples. However, in the F‐T‐treated samples, surimi gels supplemented with SO had a more uniform microstructure. Simultaneously, when SO was added from 0% to 7% in the F‐T‐treated samples, the gel strength increased from (p < .05), the physically bound water was increased from 92.90% to 94.15% (p < .05), and storage modulus was increased from 5939 to 6523 Pa. Triglycerides of SO generated hydrophobic interactions with myosin mainly in carbon chains. Computational results from MD simulations illustrated that the structure of myosin combined with triglycerides was more stable than that of myosin alone during temperature fluctuations (−20 to 4°C). During ice crystal growth, triglycerides absorbed on the myosin surface inhibited the growth of surrounding ice crystals and mitigated the ice crystal growth rate (from 7.54 to 5.99 cm/s). The addition of SO during the F‐T treatments allowed myosin to be less negatively affected by ice crystal formation and temperature fluctuations and ultimately contributed to the formation of a more uniform network gel structure.