bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in Lymph Node Assessment for Colon Cancer at the Tumor, Surgeon, and Hospital Level
Authors: Egger Michael E , Feygin Yana , Kong Maiying , Poddar Triparna , Ghosh Indranil , Xu Qian , McCabe Ryan M , McMasters Kelly M , Ellis C Tyler 
Published: January 2024

BACKGROUND:
We hypothesized that tumor- and hospital-level factors, compared with surgeon characteristics, are associated with the majority of variation in the 12 or more lymph nodes (LNs) examined quality standard for resected colon cancer.

STUDY DESIGN:
A dataset containing an anonymized surgeon identifier was obtained from the National Cancer Database for stage I to III colon cancers from 2010 to 2017. Multilevel logistic regression models were built to assign a proportion of variance in achievement of the 12 LNs standard among the following: (1) tumor factors (demographic and pathologic characteristics), (2) surgeon factors (volume, approach, and margin status), and (3) facility factors (volume and facility type).

RESULTS:
There were 283,192 unique patient records with 15,358 unique surgeons across 1,258 facilities in our cohort. Achievement of the 12 LNs standard was high (90.3%). Achievement of the 12 LNs standard by surgeon volume was 88.1% and 90.7% in the lowest and highest quartiles, and 86.8% and 91.6% at the facility level for high and low annual volume quartiles, respectively. In multivariate analysis, the following tumor factors were associated with meeting the 12 LNs standard: age, sex, primary tumor site, tumor grade, T stage, and comorbidities (all p < 0.001). Tumor factors were responsible for 71% of the variation in 12 LNs yield, whereas surgeon and facility characteristics contributed 17% and 12%, respectively.

CONCLUSIONS:
Twenty-nine percent of the variation in the 12 LNs standard is linked to modifiable factors. The majority of variation in this quality metric is associated with non-modifiable tumor-level factors.
Diagnostic utility of in vivo expressed mycobacterial RNA transcripts in pleural fluid for the differential diagnosis of tuberculous pleuritis
Authors: Kaur Prabhdeep , Sharma Sumedha , Sinha Sudhanshu Abhishek , Aggarwal Ashutosh N. , Kaur Khushpreet , Yadav Rakesh , Sethi Sunil , Bal Amanjit , Verma Indu 
Published: January 2024

ABSTRACTBackgroundTuberculous pleuritis (TBP), the extra-pulmonary manifestation of tuberculosis, is the second most common after TB lymphadenitis. Histopathology using biopsy samples is the most sensitive diagnostic procedure for TBP, however the biopsy acquisition is invasive. Therefore, better screening markers for diagnosis using pleural fluid are required. The pathogen biomarkers expressed at the site of infection may play a potential role in designing a newer diagnostic assay. Thus, the current study was planned to look for mycobacterial RNA biomarkers in TBP and to assess their diagnostic utility in pleural fluid.MethodsTBP suspects (n=261) were recruited in the current study. Out of these 45 suspects were excluded and the remaining (n=216) were divided into TBP (n=54) and non-TBP (n=162) groups based on composite reference standard. A whole genome microarray was carried usingM.tbRNA from pleural biopsies of TB patients. The data was validated using qRT-PCR and the diagnostic utility of top two highly expressed genes was assessed in pleural fluid of using a real time RT-PCR assay.ResultsOverall, 1856 genes were differentially expressed in microarray of which 1365 were upregulated and 491 were downregulated. After validation of microarray gene expression, two genes namelyRv1586andRv2543were selected for assessment of their diagnostic utility in TBP. The combined analysis for the presence of either of genes in the pleural fluid led to identification of pleural TB patients with 79.6% sensitivity and 93.28% specificity.ConclusionThe transcripts of genesRv1586andRv2543holds potential for the development of a RNA based molecular diagnostic assay in pleural fluid of TBP patients.
ClonalParabacteroidesfrom Gut Microfistulous Tracts as Transmissible Cytotoxic Succinate-Commensal Model of Crohn’s Disease Complications
Authors: Singh Vaidhvi , West Gail , Fiocchi Claudio , Good Caryn E. , Katz Jeffry , Jacobs Michael R , Dichosa Armand Earl Ko , Flask Chris , Wesolowski Mathew , McColl Cassidy , Grubb Brandon , Ahmed Sadia , Bank Nicholas C. , Thamma Kavitha , Bederman Ilya , Erokwu Bernadette , Yang Xinlin , Sundrud Mark S. , Menghini Paola , Basson Abigail Raffner , Ezeji Jessica , Viswanath Satish E , Veloo Alida , Sykes David B. , Cominelli Fabio , Rodriguez-Palacios Alex 
Published: January 2024

AbstractCrohn’s disease (CD) has been traditionally viewed as a chronic inflammatory disease that cause gut wall thickening and complications, including fistulas, by mechanisms not understood. By focusing onParabacteroides distasonis(presumed modern succinate-producing commensal probiotic), recovered from intestinal microfistulous tracts (cavernous fistulous micropathologies CavFT proposed as intermediate between ‘mucosal fissures’ and ‘fistulas’) in two patients that required surgery to remove CD-damaged ilea, we demonstrate that such isolates exert pathogenic/pathobiont roles in mouse models of CD. Our isolates are clonally-related; potentially emerging as transmissible in the community and mice; proinflammatory and adapted to the ileum of germ-free mice prone to CD-like ileitis (SAMP1/YitFc) but not healthy mice (C57BL/6J), and cytotoxic/ATP-depleting to HoxB8-immortalized bone marrow derived myeloid cells from SAMP1/YitFc mice when concurrently exposed to succinate and extracts from CavFT-derivedE. coli, but not to cells from healthy mice. With unique genomic features supporting recent genetic exchange withBacteroides fragilis-BGF539, evidence of international presence in primarily human metagenome databases, these CavFTPdisisolates could represent to a new opportunisticParabacteroidesspecies, or subspecies (‘cavitamuralis’) adapted to microfistulous niches in CD.
Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions
Authors: Li Tongqing , Liu Xueying , Zhang Sheyu , Hou Yu , Zhang Yuchao , Luo Guoyan , Zhu Xun , Tao Yanxin , Fan Mengyang , Sha Chulin , Lin Ailan , Qin Jingjing , Chen Weichang , Fu Ting , Wei Yong , Wu Qin , Tan Weihong 
Published: January 2024

SummaryDespite the well-established significance of transcription factors (TFs) in pathogenesis, their utilization as pharmacological targets has been limited by the inherent challenges associated with modulating their protein-protein and protein-DNA interactions. The lack of defined small-molecule binding pockets and the nuclear localization of TFs do not favor the use of small-molecule inhibitors, or neutral antibodies, in blocking TF interactions. Aptamers are short oligonucleotides exhibiting high affinity and specificity for a diverse range of targets. Large molecular weights, expansive blocking surfaces and efficient cellular internalization make aptamers a compelling molecular tool for use as traditional TF interaction modulators. Here, we report a structure-guided design strategy called Blocker-SELEX to develop inhibitory aptamers (iAptamer) that selectively block TF interactions. Our approach led to the discovery of iAptamers that cooperatively disrupts SCAF4/SCAF8-RNA Polymerase II (RNAP2) interactions, thereby dysregulating RNAP2-dependent gene expression and splicing and, in turn, leading to the impairment of cell proliferation. This approach was further applied to develop iAptamers to efficiently block WDR5-MYC interaction with a nexus in cancer. Taken together, our study highlights the potential of Blocker-SELEX in developing iAptamers that effectively disrupt potentially pathogenic TF interactions with attendant implications for iAptamers as chemical tools for use in the study of biological functions of TF interactions, but also for potential use in nucleic acids drug discovery.
The Uptake of Critical Perspectives in the Field of Global Mental Health: A Critical Interpretive Synthesis
Authors: Limenih Gojjam , Nouvet Elysee 
Published: January 2024

AbstractAn emancipatory movement is surging within the of global mental health (GMH) field, advancing the groundwork laid by scholars who champion a more critical, self-reflective, decolonized, and socially responsive discipline. As GMH enters its second decade, there have been numerous critiques of its origins and underlying paradigms, with increasing emphasis on critical approaches in recent publications. However, there is no comprehensive synthesis has yet been undertaken to understand how critical perspectives have been integrated into the GMH literature. To contribute to the ongoing discourse aimed at cultivating GMH as a critical and socially responsive discipline, this article employed the critical interpretive synthesis method. critical interpretive synthesis is designed to navigate the synthesis of extensive and diverse literature while actively engaging with the foundational assumptions that shape and inform the body of research via employing a critical lens to scrutinize the data. We conducted searches using PubMed, MEDLINE(OVID), PsycINFO, Scopus and EMBASE data bases; published between 2007 and February 2023. We included 58 articles that have embraced critical perspectives, whether explicitly or implicitly. Through this iterative process, five distinct themes or “four turns” emerge: (1) the inward turn, focusing on the “local” as a source of alterity, resistance, and critique; (2) turning the critical lens outward or political turn; (3) the push for a broader agenda; and (4) the reflexive turn. This article discusses the implications of four “turns” in how critical perspectives have been and are being used, in relation to the goal of developing as a socially responsive discipline.
PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury
Authors: Michel-Flutot Pauline , Cheng Lan , Thomas Samantha J , Lisi Brianna , Schwartz Harrison , Lam Sandy , Lyttle Megan , Jaffe David A , Smith George , Li Shuxin , Wright Megan C , Lepore Angelo C 
Published: January 2024

ABSTRACTHigh spinal cord injury (SCI) leads to persistent and debilitating compromise in respiratory function. Cervical SCI not only causes the death of phrenic motor neurons (PhMNs) that innervate the diaphragm, but also damages descending respiratory pathways originating in the rostral ventral respiratory group (rVRG) located in the brainstem, resulting in denervation and consequent silencing of spared PhMNs located caudal to injury. It is imperative to determine whether interventions targeting rVRG axon growth and respiratory neural circuit reconnection are efficacious in chronic cervical contusion SCI, given that the vast majority of individuals are chronically-injured and most cases of SCI involve contusion-type damage to the cervical region. We therefore employed a clinically-relevant rat model of chronic cervical hemicontusion to test therapeutic manipulations aimed at reconstructing damaged rVRG-PhMN-diaphragm circuitry to achieve recovery of respiratory function. At a chronic time point post-injury, we systemically administered: an antagonist peptide directed against phosphatase and tensin homolog (PTEN), a central inhibitor of neuron-intrinsic axon growth potential; an antagonist peptide directed against receptor-type protein tyrosine phosphatase sigma (PTPσ), another important negative regulator of axon growth capacity; or a combination of these two peptides. PTEN antagonist peptide (PAP4) promoted partial recovery of diaphragm motor activity out to nine months post-injury, while PTPσ peptide did not impact diaphragm function after cervical SCI. Furthermore, PAP4 promoted robust growth of descending bulbospinal rVRG axons caudal to the injury within the denervated portion of the PhMN pool, while PTPσ peptide did not affect rVRG axon growth at this location that is critical to control of diaphragmatic respiratory function. In conclusion, we find that, when PTEN inhibition is targeted at a chronic time point following cervical contusion that is most relevant to the SCI clinical population, our non-invasive PAP4 strategy can successfully promote significant regrowth of damaged respiratory neural circuitry and also partial recovery of diaphragm motor function.HIGHLIGHTSPTEN antagonist peptide promotes partial diaphragm function recovery in chronic cervical contusion SCI.PTPσ inhibitory peptide does not impact diaphragm function recovery in chronic cervical contusion SCI.PTEN antagonist peptide promotes growth of bulbospinal rVRG axons in chronic cervical contusion SCI.PTPσ peptide does not affect rVRG axon growth in chronic cervical contusion SCI.
Comparing the homogeneity and genotypes of large and small-scale coliving buildings in the modern Western world
Authors: Alyedreessy Emad , Dalton Ruth 
Published: January 2024

PurposeContemporary coliving is a rapidly developing housing typology, characterised by high-density private living spaces integrated with various shared, mixed-use amenities. The purpose of this research is to quantitatively examine the spatial configurations of coliving building systems, and the integration of programmatic space labels, to provide insights for architects and researchers into the homogeneity and genotypical patterns embedded within these contexts.Design/methodology/approachColiving buildings of various scales from the United Kingdom and the USA were examined using small graph matching and inequality genotypes. The former was adopted to identify a genotype signature and assess homogeneity levels, whilst the latter provided a comparative analysis of the ranked integration values for space labels within these building systems.FindingsAlthough local samples exhibited superior levels of homogeneity compared to the sample population (n = 18), the latter still evinced a marked homogeneity and no statistical difference in building system integration (mean real relative asymmetry (RRA)). Local large-scale samples showed the greatest homogeneity and building system integration of all sample groups, whilst a statistically significant distinction in building system integration was evident between large- and small-scale samples. However, a comparison of space label integration (RRA) across different building scales demonstrated that a potential genotypical pattern exists between small- and large-scale samples.Originality/valueThrough the identification of homogeneity and integration values related to scale and location, this research establishes an empirical, methodological framework for the generalisable spatial analysis of contemporary coliving buildings. Furthermore, genotypical patterns provide insights into space labels that are most likely to encourage copresence and social encounters between residents.
The effect of sponsored video customization on video shares: the critical moderating role of influencer and brand characteristics
Authors: Chen Li , Chen Yiwen , Pan Yang 
Published: January 2024

Purpose
This study aims to empirically test how sponsored video customization (i.e. the degree to which a sponsored video is customized for a sponsoring brand) affects video shares differently depending on influencer characteristics (i.e. mega influencer and expert influencer) and brand characteristics (i.e. brand establishment and product involvement).

Design/methodology/approach
This study uses a unique real-world data set that combines coded variables (e.g. customization) and objective video performance (e.g. sharing) of 365 sponsored videos to test the hypotheses. A negative binomial model is used to analyze the data set.

Findings
This study finds that the effect of video customization on video shares varies across contexts. Video customization positively affects shares if they are made for well-established brands and high-involvement products but negatively influences shares if they are produced by mega and expert influencers.

Research limitations/implications
This study extends the influencer marketing literature by focusing on a new media modality – sponsored video. Drawing on the multiple inference model and the persuasion knowledge theory, this study teases out different conditions under which video customization is more or less likely to foster audience engagement, which both influencers and brands care about. The chosen research setting may limit the generalizability of the findings of this study.

Practical implications
The findings suggest that mega and expert influencers need to consider if their endorsement would backfire on a highly customized video. Brands that aim to engage customers with highly-customized videos should gauge their decision by taking into consideration their years of establishment and product involvement. For video-sharing platforms, especially those that are planning to expand their businesses to include “matching-making services” for brands and influencers, the findings provide theory-based guidance on optimizing such matches.

Originality/value
This paper fulfills an urgent research need to study how brands and influencers should produce sponsored videos to achieve optimal outcomes.
Seasonal electricity consumption forecasting: an approach with novel weakening buffer operator and fractional order accumulation grey model
Authors: Mi Chuanmin , Gou Xiaoyi , Ren Yating , Zeng Bo , Khalid Jamshed , Ma Yuhuan 
Published: January 2024

PurposeAccurate prediction of seasonal power consumption trends with impact disturbances provides a scientific basis for the flexible balance of the long timescale power system. Consequently, it fosters reasonable scheduling plans, ensuring the safety of the system and improving the economic dispatching efficiency of the power system.Design/methodology/approachFirst, a new seasonal grey buffer operator in the longitudinal and transverse dimensional perspectives is designed. Then, a new seasonal grey modeling approach that integrates the new operator, full real domain fractional order accumulation generation technique, grey prediction modeling tool and fruit fly optimization algorithm is proposed. Moreover, the rationality, scientificity and superiority of the new approach are verified by designing 24 seasonal electricity consumption forecasting approaches, incorporating case study and amalgamating qualitative and quantitative research.FindingsCompared with other comparative models, the new approach has superior mean absolute percentage error and mean absolute error. Furthermore, the research results show that the new method provides a scientific and effective mathematical method for solving the seasonal trend power consumption forecasting modeling with impact disturbance.Originality/valueConsidering the development trend of longitudinal and transverse dimensions of seasonal data with impact disturbance and the differences in each stage, a new grey buffer operator is constructed, and a new seasonal grey modeling approach with multi-method fusion is proposed to solve the seasonal power consumption forecasting problem.HighlightsThe highlights of the paper are as follows:A new seasonal grey buffer operator is constructed.The impact of shock perturbations on seasonal data trends is effectively mitigated.A novel seasonal grey forecasting approach with multi-method fusion is proposed.Seasonal electricity consumption is successfully predicted by the novel approach.The way to adjust China's power system flexibility in the future is analyzed.
Investigating online shopping behavior of generation Z: an application of theory of consumption values
Authors: Rana S.M. Sohel , Azim Sheikh Mohammad Fauzul , Arif Arifur Rahman Khan , Sohel Mohammed Sohel Islam , Priya Farhana Newaz 
Published: January 2024

PurposeThe tech savvy generation Z consumers constitute a significant market of online shopping. Understanding their shopping behavior is thus a pressing need to expand the e-commerce business. Under this backdrop, the study aims to predict the online shopping behavior of generation Z customers in Bangladesh.Design/methodology/approachThis study used the theory of consumption values (TCV) along with shopping enjoyment to understand the online shopping behavior of generation Z. A structured set of questionnaire was used to gather the responses on a five point Likert scale. A total of 411 valid responses were considered after discarding incomplete responses. The collected data were analyzed using the partial least squares structural equation modeling (PLS-SEM) approach with the help of smart PLS 4.0 software.FindingsThe statistical findings reveal that functional value is the most significant determinant of online shopping behavior among generation Z followed by social value, conditional value and epistemic value. The study also reveals that relationship between emotional value and online shopping behavior and relationship between conditional value and online shopping behavior is moderated by shopping enjoyment.Originality/valueThe paper contributes to the consumer behavior literature as the findings provide a comprehensive model from values perspectives to understand online shopping behavior among Gen Z customers in a developing country like Bangladesh. The findings of this study offer important insights to the marketers also since it reveals the values consumers consider while shopping online. The findings might help practitioners develop their online strategies to expand the business.
Investigating nexus between corporate re-branding and stock market performance: a study of Indian service sector
Authors: Kaul Pushpanjali , Arora Sangeeta 
Published: January 2024

PurposeThe present study, by using signaling perspective aims to investigate short-term valuation impact of rebranding announcements (with name change) on stock performance of 160 service firms listed on NSE NIFTY-500 over the period of 2000–2019.Design/methodology/approachAn event study methodology is used to estimate the cumulative abnormal returns (CARs) and its statistical significance is tested with both parametric and non-parametric test-statistics. Separate analysis has been conducted for firms with “major vs minor” and “restructuring vs non-restructuring” name change.FindingsFindings of the study suggest that rebranding decisions are negatively associated with abnormal returns around the announcement period indicating strong disapproval of name change event. In addition, investors formed strong adverse opinion for major name change firms as compared to minor name change firms. Further, restructured name change sample document larger negative drift than non-restructured sample.Practical implicationsFindings offer substantial repercussions for shareholders who can make informed judgments about name change as a signal of reinventing brand identity. Managers should announce detailed rationale behind name change decision to market for enhancing corporate reputation.Originality/valueThis study contributes to marketing-finance interface literature and is first to examine market reaction to name change of Indian service firms and moreover, made a distinction between major vs minor and restructured vs non-restructured name change events for these firms.