bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiome dynamics and products profiles of biowaste fermentation under different organic loads and additives
Authors: Zhu Xinyu , Li Ping , Ju Feng 
Published: November 2023

AbstractBiowaste fermentation is a promising technology for low‐carbon print bioenergy and biochemical production. Although it is believed that the microbiome determines both the fermentation efficiency and the product profiles of biowastes, the explicit mechanisms of how microbial activity controls fermentation processes remained to be unexplored. The current study investigated the microbiome dynamics and fermentation product profiles of biowaste fermentation under different organic loads (5, 20, and 40 g‐VS/L) and with additives that potentially modulate the fermentation process via methanogenesis inhibition (2‐bromoethanesulfonate) or electron transfer promotion (i.e., reduced iron, magnetite iron, and activated carbon). The overall fermentation products yields were 440, 373 and 208 CH4‐eq/g‐VS for low‐, medium‐ and high‐load fermentation. For low‐ and medium‐load fermentation, volatile fatty acids (VFAs) were first accumulated and were gradually converted to methane. For high‐load fermentation, VFAs were the main fermentation products during the entire fermentation period, accounting for 62% of all products. 16S rRNA‐based analyses showed that both 2‐bromoethanesulfonate addition and increase of organic loads inhibited the activity of methanogens and promoted the activity of distinct VFA‐producing bacterial microbiomes. Moreover, the addition of activated carbon promoted the activity of H2‐producing Bacteroides, homoacetogenic Eubacteriaceae and methanogenic Methanosarcinaceae, whose activity dynamics during the fermentation led to changes in acetate and methane production. The current results unveiled mechanisms of microbiome activity dynamics shaping the biowaste fermentation product profiles and provided the fundamental basis for the development of microbiome‐guided engineering approaches to modulate biowaste fermentation toward high‐value product recovery.
Towards development of effective policies and regulations for sustainable off‐grid solar electronic waste management systems in Kenya
Authors: Mugendi Kariuki David , Mireri Caleb Ombuor , Enevoldsen Martin Korch 
Published: November 2023

AbstractOff‐grid solar systems provide clean and affordable energy sources. Adoption of off‐grid Solar energy is becoming increasingly popular in Kenya as a source of renewable energy, with an estimated 10 million people using off‐grid solar power systems as of the end of year 2022. However, the rising off‐grid solar systems technology uptake comes with a growing amount of solar e‐waste, which can have harmful environmental and health effects if not managed properly. Current data on the exact amount of solar e‐waste being generated in Kenya is unavailable and this amount will continue to rise with the expiry of many of these off‐grid solar systems lifespans. This study through stakeholder's workshop and document review data collection and analysis approaches, established that Kenya just like many countries in the Global South has a robust general waste policy and regulation management framework. However, it lacks specific policies and regulations on off‐grid‐solar electronic waste management a challenge that many countries in the Global North have made considerate steps in addressing. In addition, there is a lack of awareness of the hazardous nature of off‐grid solar systems' e‐waste components to both consumers and institutions of governance. There is a lack of adequate infrastructure and sufficient systems for off‐grid solar e‐waste management in the country. Enforcement and implementation challenges of the existing general waste regulations due to limited resources and capacity and corruption culture are major impending factors. This calls for the development of effective policies and regulations to ensure sustainable off‐grid solar e‐waste management in Kenya against the backdrop of the rising uptake of off‐grid solar systems.
Circular economy strategy for the valorization of fly ash as a substitute for cement in monoliths (resistance and reactivity evaluation)
Authors: Morales Luisa F. , Herrera Katherine , López Julián E. , Aguado Roberto , Saldarriaga Juan F. 
Published: November 2023

AbstractFly ash is currently a problem in different companies, mainly in thermoelectric plants, which must follow a production and consumption model that involves reusing, renewing, and recycling, thus contributing to the circular economy. This work aims to evaluate the reactivity and compressive strength of different types of ashes in concrete monoliths. For this purpose, sugarcane bagasse (SCBA), bituminous coal (BC), and untreated hazardous waste (RUD) were evaluated as replacements for cement. Monoliths and mortars have been manufactured in different mixtures, taken to a curing room, and their compressive strength and reactivity have been determined at different times (up to 28 days for the monoliths and up to 90 for the mortars), mainly in order to check the formation of calcium silicate hydrate (CSH) gels. In the monolith tests, the best performances have been with SCBA and BC, which have been used for the manufacture of the mortars. On day 56, the behavior of the replacement of 30% fly ash (15% BC:15% SCBA) presents a type H mortar behavior, with better results than the control. By day 90, all replacements had the same resistance as M mortars and even higher resistances than the control. This demonstrates the feasibility of its use in the production of Portland cement for the manufacture of low‐performance inputs. This implies the possible reduction of impacts, both in waste disposal sites and in emissions caused by the construction industry, thus contributing to the circular economy.
Tumour‐microenvironment‐responsive Na2S2O8 nanocrystals encapsulated in hollow organosilica–metal–phenolic networks for cycling persistent tumour‐dynamic therapy
Authors: Li Yang , Lin Jinyan , He Yueyang , Wang Kaiyuan , Huang Cailin , Zhang Ruifeng , Liu Xiaolong 
Published: November 2023

AbstractTraditional tumour‐dynamic therapy still inevitably faces the critical challenge of limited reactive oxygen species (ROS)‐generating efficiency due to tumour hypoxia, extreme pH condition for Fenton reaction, and unsustainable mono‐catalytic reaction. To fight against these issues, we skilfully develop a tumour‐microenvironment‐driven yolk‐shell nanoreactor to realize the high‐efficiency persistent dynamic therapy via cascade‐responsive dual cycling amplification of •SO4−/•OH radicals. The nanoreactor with an ultrahigh payload of free radical initiator is designed by encapsulating the Na2S2O8 nanocrystals into hollow tetra‐sulphide‐introduced mesoporous silica (HTSMS) and afterward enclosed by epigallocatechin gallate (EG)‐Fe(II) cross‐linking. Within the tumour microenvironment, the intracellular glutathione (GSH) can trigger the tetra‐sulphide cleavage of nanoreactors to explosively release Na+/S2O82−/Fe2+ and EG. Then a sequence of cascade reactions will be activated to efficiently generate •SO4− (Fe2+‐catalyzed S2O82− oxidation), proton (•SO4−‐catalyzed H2O decomposition), and •OH (proton‐intensified Fenton oxidation). Synchronously, the oxidation‐generated Fe3+ will be in turn recovered into Fe2+ by excessive EG to circularly amplify •SO4−/•OH radicals. The nanoreactors can also disrupt the intracellular osmolarity homeostasis by Na+ overload and weaken the ROS‐scavenging systems by GSH exhaustion to further amplify oxidative stress. Our yolk–shell nanoreactors can efficiently eradicate tumours via multiple oxidative stress amplification, which will provide a perspective to explore dynamic therapy.
A fast and accurate method for transport and dispersion of phosphogypsum in coastal zones: Application to Jorf Lasfar
Authors: Ouardghi Abdelouahed , Seaid Mohammed , El‐Amrani Mofdi , El Mocayd Nabil 
Published: November 2023

SummaryWe present a numerical method for modelling and simulation of transport and dispersion of phosphogypsum in the Jorf Lasfar coastal zone located on the Atlantic Ocean at Morocco. The governing equations consist of the well‐established barotropic ocean model including the barometric pressure, friction terms, Coriolis and wind stresses. To model transport and dispersion of phosphogypsum we consider an advection‐diffusion equation with an anisotropic dispersion tensor and source terms. As a numerical solver, we propose a novel multilevel adaptive semi‐Lagrangian finite element method. The proposed method combines the modified method of characteristics to deal with convection terms, the finite element discretization to handle complex geometries, a projection‐based algorithm to solve the Stokes problem, and an adaptive ‐projection using quadrature rules to improve the efficiency and accuracy of the method. Numerical results are presented to demonstrate the high resolution of the proposed method and to confirm its capability to provide accurate and efficient simulations for transport and dispersion of phosphogypsum in the Jorf Lasfar coastal zone.
The Big Circles in Jordan: First absolute ages using rock luminescence surface dating
Authors: al Khasawneh Sahar , Abudanah Fawzi , Thompson Warren , Murray Andrew 
Published: November 2023

AbstractIn this study, we provide the first absolute ages for a Big Circle megalithic structure in Jordan, using rock surface luminescence dating of the buried surface of rocks collected from circle J4 in southern Jordan. Five rocks were used for this study. All rocks showed evidence of previous daylight exposure before being used in the construction of the circle. The exposure was sufficient to bleach the latent luminescence signal to a negligible level compared to the subsequent burial dose. Three rocks gave indistinguishable ages, and were last exposed to daylight in 1500 ± 100 BCE; this is very likely to be the date of circle construction. Two others gave younger ages, indicating later disturbance or reworking. These new results provide very strong evidence for construction during the Late Bronze Age, and refute the earlier hypothesis of construction during Umayyad period (661–750 CE) as a hunting trap.
Paleoshoreline reconstruction: A proposed method to approach submerged prehistoric landscapes of Espiritu Santo Island, Baja California Sur, Mexico
Authors: Robles‐Montes Mayra C. , Martínez‐Flores Guillermo , Faught Michael K. , Nava‐Sánchez Enrique H. 
Published: November 2023

AbstractWhen the first Americans inhabited the area now known as Isla Espiritu Santo, around 12.5 and 6 ka, the sea level continuously rose. This resulted in the loss of the coastal territory and the retreat of the human population further inland. Part of the archaeological evidence of this period currently lies over the seafloor and under the seabed. Therefore, reconstructing paleoshorelines is a necessary first step toward submerged precontact archaeology and a broad understanding of the spatial context in which those human populations interacted and how the landscapes changed. Isla Espiritu Santo is of prehistoric importance as it contains numerous Paleocoastal tradition sites as early as ~12,400 Cal B.P. This research aims to reconstruct the changing shoreline positions as sea levels rose around Isla Espiritu Santo between 12.5 and 6.5 ka. We apply numerical modeling to map digital elevation models at 1 ka intervals by estimating the changes in the morphology of the seafloor according to the deposition rates and global sea‐level curve. The results show the evolution of coastal morphology and paleoshoreline's position. Three primary geoforms are proposed: (1) coastal plains, (2) tombolo, and (3) a coastal lagoon–island barrier system. This also offers insights into the physical aspect of submerged prehistoric landscapes and the possible resource exploitation options of early societies. In this research, the reconstruction of submerged landscapes seeks to contribute to the long‐term goal of locating submerged precontact sites.
Regaining Trust in Public Health and Biomedical Science following Covid: The Role of Scientists
Authors: Caplan Arthur L. 
Published: November 2023

AbstractBiomedical science suffered a loss of trust during the Covid‐19 pandemic. Why? One reason is a crisis fueled by confusion over the epistemology of science. Attacks on biomedical expertise rest on a mistaken view of what the justification is for crediting scientific information. The ideas that science is characterized by universal agreement and that any evolution or change of beliefs about facts and theories undermines trustworthiness in science are simply false. Biomedical science is trustworthy precisely because it is fallible, admits error, adjusts to new information, and, most importantly, is practical. Successful diagnosis and cure demarcate the boundaries of warranted knowledge. The other reason is sociological. As the pandemic made all too clear, the loss of faith in scientific experts was due to the failure of most of them to engage in regular public dialogue, reflecting a failure to recognize the obligation that science has to bolster trust in its work and findings by concerted public engagement.
Lidocaine aerosol preoperative application for improving the comfort of pediatric patients undergoing tonsillectomy and adenoidectomy: A prospective randomized controlled trial
Authors: Cheng Lixia , Zhang Fazhong , Ma Guifen , Peng Qingcai , Zhang Mingyue , Sun Yuanming , Xia Xiaoqiong , Li Yuanhai 
Published: November 2023

AbstractBackground and AimsThe use of lidocaine aerosol for pediatric tonsil and adenoidectomy has been reported less frequently. We hope to improve the perioperative comfort of pediatric patients undergoing these procedures by applying lidocaine aerosol.MethodsA total of 122 pediatric patients receiving tonsil and adenoidectomy were randomly divided into a lidocaine aerosol group (Group L) and a saline group (Group C), with 61 patients in each group; 2.4% alkaline lidocaine aerosol and saline were sprayed in the pharynx before induction. Our primary outcome were the incidence and rate ratio (RR) of postoperative pharyngeal complications (oropharyngeal dryness, dysphagia, hoarseness, and sore throat) and the pharyngeal comfort score, the latter of which was assessed by the occurrence of the above complications (yes = 0 point, none = 1 point). The secondary outcomes included preoperative and intraoperative blood pressure and heart rate, the incidence of choking during the induction period, the intraoperative opioid dosage, and the pain level and depth of sedation at 2, 6, and 24 h postoperatively. Statistical software used in this study included PASS15.0, SPSS 26.0, and GraphPad Prism 9.3.1, and statistical methods used included the t‐test, the χ² test, the Mann–Whitney U test, and the repeated measures analysis of variance.ResultsThe incidence and RR of postoperative pharyngeal complications such as oropharyngeal dryness (RR: 0.667, 95% confidence interval [CI]: 0.458–0.970, p = 0.03), dysphagia (RR: 0.333, 95% CI: 0.114–0.976, p = 0.03), hoarseness (RR: 0.647, 95% CI: 0.433–0.967, p = 0.03), and sore throat (RR: 0.727, 95% CI: 0.547–0.967, p = 0.03) were significantly lower in Group L than in Group C at 2 h postoperatively, and the incidence and RR of postoperative sore throat was significantly lower in Group L than in Group C at 6 h postoperatively (RR: 0.717, 95% CI: 0.547–0.942, p = 0.01). The postoperative pharyngeal comfort scores were significantly higher in Group L than in Group C at all postoperative time points (p < 0.05). The Ramsay sedation score was significantly higher (p < 0.01) and FLACC (face, legs, activity, crying, and consolability) score was significantly lower (p < 0.01) in Group L than in Group C at 2 h postoperatively. In Group C, the blood pressure and heart rate significantly faster at all time points immediately after intubation and afterward, except at the end of surgery (p < 0.05).ConclusionsIn pediatric tonsil and adenoidectomy, the application of lidocaine aerosol before induction can reduce the incidence of postoperative pharyngeal complications, improve the child's postoperative pharyngeal comfort, and better realize perioperative “comfort medical treatment.”
Rare earth elements as tracers of iron ore tailings on the Brazilian eastern continental shelf
Authors: Cagnin Renata C. , Costa Eduardo S. , Longhini Cybelle M. , da Silva Cesar A. , Sá Fabian , Neto Renato R. 
Published: November 2023

Abstract
Iron ore tailings are stored in large dams and pose risks to the environment around the world. In Brazil, the rupture of these dams has become frequent and has generated environmental and social concern. Rare earth elements are good tracers of sediment sources and our results indicated chronic contamination of the seabed sediment from the marine region affected by the Fundão Dam tailings since 2015, including areas of environmental protection. This research, carried out between November 2018 and September 2021, with a database of 575 samples, showed a greater amount of contaminated material in the marine region adjacent to the Doce River mouth. Although data suggest prior mining contamination of the Doce River basin, the Fundão episode was an empirical and massive example of the environmental damage caused by these human activities over the centuries, showing that the impact remains in the shallow marine environments for years. Integr Environ Assess Manag 2024;20:179–188. © 2023 SETAC
Oriented polyaniline/poly‐l‐lactic acid/gelatin nanofiber scaffolds promote outgrowth of spiral ganglion neurons
Authors: Liu Li , Chen Mengyu , Zhang Junming , Li Haobo , Li Zhaoxia , Song Jianhao , Ma Shutao , Wang Yingjie , Lou Xiangxin 
Published: November 2023

AbstractSensorineural hearing loss (SNHL) is caused by the loss of sensory hair cells (HCs) and/or connected spiral ganglion neurons (SGNs). The current clinical conventional treatment for SNHL is cochlear implantation (CI). The principle of CI is to bypass degenerated auditory HCs and directly electrically stimulate SGNs to restore hearing. However, the effectiveness of CI is limited when SGNs are severely damaged. In the present study, oriented nanofiber scaffolds were fabricated using electrospinning technology to mimic the SGN spatial microenvironment in the inner ear. Meanwhile, different proportions of polyaniline (PANI), poly‐l‐lactide (PLLA), gelatin (Gel) were composited to mimic the composition and mechanical properties of auditory basement membrane. The effects of oriented PANI/PLLA/Gel biomimetic nanofiber scaffolds for neurite outgrowth were analyzed. The results showed the SGNs grew in an orientation along the fiber direction, and the length of the protrusions increased significantly on PANI/PLLA/Gel scaffold groups. The 2% PANI/PLLA/Gel group showed best effects for promoting SGN adhesion and nerve fiber extension. In conclusion, the biomimetic oriented nanofiber scaffolds can simulate the microenvironment of SGNs as well as promote neurite outgrowth in vitro, which may provide a feasible research idea for SGN regeneration and even therapeutic treatments of SNHL in future.
Content and distribution of cyanogenic compounds in cassava roots and leaves in association with physiological age
Authors: Ospina María A. , Tran Thierry , Pizarro Monica , Luna Jorge , Salazar Sandra , Londoño Luis , Ceballos Hernan , Becerra Lopez‐Lavalle Luis A. , Dufour Dominique 
Published: November 2023

AbstractBackgroundCassava roots are widely consumed in tropical regions of Asia, Africa, and Latin America. Although the protein, vitamin, carotenoid, and mineral content in the leaves makes them a nutritionally attractive option, their consumption is limited due to their high levels of cyanogenic compounds (CCs). In this study, the CC content in different parts of the plant (leaves, storage root cortex, and parenchyma) was assessed at harvest for 50 landrace genotypes representative of cassava diversity in Latin America. The changes in CC in leaves at different physiological ages (3, 6, 9, and 11 months after planting) were also investigated.ResultsThe average CC was higher in the cortex (804 ppm) and leaves (655 ppm) than in root parenchyma (305 ppm). Genotypes from different regions of Latin America, as identified by seven genetic diversity groups, differed significantly in CC levels. The Andean and Amazon groups had, respectively, the lowest (P = 0.0008) and highest (P < 0.0001) CC levels in all three parts of the plants. Cyanogenic compound concentrations were higher in leaves from young plants (P < 0.0001) and decreased with increasing physiological age.ConclusionThe results help to guide the selection of parental lines with low CC levels for breeding and to contribute to the expanded use of cassava and its by‐products for food and feed. Cassava for fresh consumption, especially, requires varieties with low total CC content, especially in the root cortex and parenchyma. COL1108 (204, 213, and 174 ppm, respectively, in the parenchyma, cortex, and leaves) and PER297 (83, 238, and 299 ppm, respectively, in the parenchyma, cortex, and leaves) can fulfill this requirement. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Metabolite profiling reveals the influence of grapevine genetic distance on the chemical signature of juices
Authors: Gomez Hector Alonzo Gomez , Niederauer Guilherme Francio , Minatel Igor Otavio , Antunes Elisa Ribeiro Miranda , Carneiro Mara Junqueira , Sawaya Alexandra Christine Helena Frankland , Zanus Mauro Celso , Ritschel Patrícia Silva , Quecini Vera , Pereira Lima Giuseppina Pace , Marques Marcia Ortiz Mayo 
Published: November 2023

AbstractBACKGROUNDYield, disease tolerance, and climate adaptation are important traits in grapevine genetic breeding programs. Selection for these characteristics causes unpredictable changes in primary and specialized metabolism, affecting the physicochemical properties and chemical composition of the berries and their processed products, juice, and wine. In this study, we investigated the influence of the genetic distance between grapevine genotypes on the chemical signatures of the juices, by integrating comprehensive metabolic profiling to genetic analyses.RESULTSThe studied grapevine cultivars exhibited low genetic diversity. Breeding for agronomic traits promoted higher contents of soluble sugars, total phenolics, and anthocyanins in the juices. Untargeted juice metabolomics identified a total of 147 metabolites, consisting of 30 volatiles, 21 phenolics, and 96 ultra‐high‐performance liquid chromatography–mass spectrometry (UHPLC‐MS) features. Juices from grapes of the most recent cultivars exhibited increased levels of trans‐resveratrol, catechin, and luteolin. The blend of volatiles from juices of later cultivars was also more complex, consisting of 29 distinct metabolites in ‘BRS Magna’. Grapes from ‘BRS Carmem’, an intermediate cultivar, gave the most divergent UHPLC‐MS juice profile.CONCLUSIONContents of soluble solids, total phenolics, and anthocyanins in grape juices were increased by controlled crosses and hybrid selection. Integrative analyses demonstrated that the juices’ metabolic profiles accurately represent the cultivars’ genetic distances. Juices from ‘BRS Violeta’ and ‘BRS Magna’ show relevant positive association with health‐related phenolics and a distinct set of odor volatiles, although these characteristics were specifically sought by breeding. © 2023 Society of Chemical Industry.