bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of indocyanine green fluorescence angiography on surgeon action and anastomotic leak in colorectal resections. A systematic review and meta-analysis
Authors: Mc Entee Philip D. , Singaravelu Ashokkumar , Boland Patrick A. , Moynihan Alice , Creavin Ben , Cahill Ronan A. 
Published: February 2025

Abstract

Background
Indocyanine green fluorescence angiography (ICGFA) during colorectal surgery either reassures surgeons regarding intestinal perfusion sufficiency or prompts changed surgical strategy by indicating unsuspected insufficiency. This study describes existing evidence supporting ICGFA use in colorectal surgery, particularly regarding impact on intraoperative decisions.

Methods
Searches were performed on PubMed, ScienceDirect, Scopus, Web of Science, Cochrane Collaboration databases on 5th December 2023, updated to 19th August 2024. Full English language publications of clinical studies in human patients undergoing colorectal resection with primary anastomosis with the use of ICGFA to assess bowel perfusion intraoperatively, with a control group, were included. Pooling of anastomotic leak (AL) rates was performed for primary outcome analysis with odds ratio (OR) and number-needed-to-treat (NNT) calculated regarding leak reduction.

Results
45 studies comprising 14,333 patients were included, with 7 randomised controlled trials (2911 patients). Overall, AL rate was 6.8%, 4.5% with ICGFA and 8.5% without (OR:0.47, p < 0.001, NNT 23), increasing to 9.5%, 7.5% and 11.6%, respectively, in randomised controlled trials (OR:0.62, p < 0.01, NNT 25). In rectal resections, AL rate was 4.7% with ICGFA vs 11.5% without (OR: 0.38, p < 0.0001). 26 studies performed ICGFA before and after anastomosis formation and 19 used ICGFA only prior to bowel transection, with no significant difference of AL rate reduction on subgroup testing. ICGFA prompted a change in surgical plan in 8.4% of thirty-four studies reporting this. Interestingly, in these studies, leak rates overall were 3.7% when ICGFA matched surgeon judgement versus 5.7% when it prompted change (OR 0.51, p < 0.0025), versus 7.7% without (OR 0.45, p < 0.0001). In rectal resections, these figures were 5%, 8.8% (OR 0.42, p = 0.01) and 12.0% (OR0.39, p < 0.0001), respectively.

Conclusions
ICGFA colorectal perfusion assessment is associated with lower anastomotic leak rates, especially when confirming surgeons’ judgement, and may so stratify patients post-operatively regarding subsequent anastomotic leak rate.
Urinary Dickkopf-related protein 3 as a novel biomarker for kidney function decline in children with Alport syndrome
Authors: Boeckhaus Jan , Tönshoff Burkhard , Weber Lutz T. , Pape Lars , Latta Kay , Fehrenbach Henry , Lange-Sperandio Baerbel , Kettwig Matthias , König Sabine , John-Kroegel Ulrike , Gellermann Jutta , Galiano Matthias , Jami Sima , Pieper Dennis , Dihazi Gry Helene , Hafke Angelika , Kohl Stefan , Liebau Max C. , König Jens , Haffner Dieter , Gross Oliver , Wallbach Manuel 
Published: February 2025

Abstract

Background
Chronic kidney disease (CKD) seriously affects the well-being and shortens the life expectancy of children and adolescents, but its progression is challenging to predict. Therefore, there is an urgent need for biomarkers that can identify children at risk of faster CKD progression. Alport syndrome (AS) is the most common monogenetic glomerular kidney disease. Urinary Dickkopf-related protein 3 (DKK3) is associated with a decline in estimated glomerular filtration rate (eGFR) in adults and children with advanced CKD. However, its potential for early detection of CKD and its prognostic value in children with AS remain unknown.

Methods
Urine samples from 49 children enrolled in the EARLY PRO-TECT Alport trial were analyzed to evaluate whether DKK3 could identify children with AS to be at risk for faster CKD progression.

Results
DKK3 levels in patients with AS were higher than those of healthy individuals reported in the literature. DKK3 levels were more elevated in patients with later stages of AS. Furthermore, children who were not treated with renin angiotensin system inhibitors (RASi) had higher DKK3 levels than treated children. Children with above-average DKK3 levels were more likely to have increased albuminuria after 2 years of follow-up than children with below-average DKK3 levels.

Conclusion
Urinary DKK3 is significantly elevated in children at early stages of AS. There was a potential association between higher DKK3 levels, worsening albuminuria, and a decline in kidney function. These findings suggest that DKK3 may be a prognostic marker for predicting the risk of kidney damage in children with AS.

Graphical Abstract
Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study
Authors: Jeong Sung Hoon , Chun Seong Min , Lee Hyunji , Kim Miji , Choi Mira , Leigh Ja-Ho 
Published: February 2025

Abstract

Purpose
Breast cancer-related lymphedema (BCRL) is a well-known complication of breast cancer treatment, which often includes chemotherapy. This study aimed to investigate the association between chemotherapy and the risk of developing BCRL in patients with new-onset breast cancer.

Methods
This nationwide retrospective cohort study utilized data from the Korean National Health Insurance database and the Korea National Cancer Incidence Database (2006–2017). Using 1:1 propensity score matching, 37,202 participants who received chemotherapy and 37,202 who did not receive chemotherapy were included in the analysis. Cox proportional hazard regression models were employed to examine the association between chemotherapy and the risk of developing BCRL.

Results
Among the 74,404 participants, 11,508 (15.5%) were diagnosed with BCRL during the follow-up period. Compared with patients who did not receive chemotherapy, the risk of BCRL was higher in patients undergoing chemotherapy (hazard ratio [95% confidence interval]: 1.95 [1.87–2.04]). Furthermore, compared to patients who did not receive chemotherapy, the risk of BCRL was confirmed in the taxane (3.38 [3.19–3.58]), antimetabolite (1.79 [1.67–1.91]), and anthracycline (1.49 [1.41–1.56]) chemotherapy groups.

Conclusion
Chemotherapy administration following a diagnosis of breast cancer increases the risk of BCRL. Therefore, vigilant monitoring for BCRL, particularly in patients undergoing chemotherapy with taxanes, antimetabolites, or anthracyclines, is warranted during follow-up.
Machine learning algorithms for predicting future curve using first and second visit data in female adolescent idiopathic scoliosis patients
Authors: Ohyama Shuhei , Maki Satoshi , Kotani Toshiaki , Ogata Yosuke , Sakuma Tsuyoshi , Iijima Yasushi , Akazawa Tsutomu , Inage Kazuhide , Shiga Yasuhiro , Inoue Masahiro , Arai Takahito , Toshi Noriyasu , Tokeshi Soichiro , Okuyama Kohei , Tashiro Susumu , Suzuki Noritaka , Eguchi Yawara , Orita Sumihisa , Minami Shohei , Ohtori Seiji 
Published: February 2025

Abstract

Purpose
This study was designed to develop a machine learning (ML) model that predicts future Cobb angle in patients with adolescent idiopathic scoliosis (AIS) using minimal radiographs and simple questionnaires during the first and second visits.

Methods
Our study focused on 887 female patients with AIS who were initially consulted at a specialized scoliosis center from July 2011 to February 2023. Patient data, including demographic and radiographic data based on anterior-posterior and lateral whole-spine radiographs, were collected at the first, second, and final visits. ML algorithms were employed to develop individual regression models for future Cobb angles of each curve type (proximal thoracic: PT, main thoracic: MT, and thoracolumbar/lumbar: TLL) using PyCaret in Python. Multiple models were explored and analyzed, with the selection of optimal models based on the coefficient of determination (R2) and median absolute error (MAE).

Results
For the future curve of PT, MT, and TLL, the top-performing models exhibit R2 of 0.73, 0.63, and 0.61 and achieve MAE of 2.3°, 4.0°, and 4.2°.

Conclusions
The ML-based model using items commonly evaluated at the first and second visits accurately predicted future Cobb angles in female patients with AIS.
Parametric model order reduction for a wildland fire model via the shifted POD-based deep learning method
Authors: Burela Shubhaditya , Krah Philipp , Reiss Julius 
Published: February 2025

Abstract
Parametric model order reduction techniques often struggle to accurately represent transport-dominated phenomena due to a slowly decaying Kolmogorov n-width. To address this challenge, we propose a non-intrusive, data-driven methodology that combines the shifted proper orthogonal decomposition (POD) with deep learning. Specifically, the shifted POD technique is utilized to derive a high-fidelity, low-dimensional model of the flow, which is subsequently utilized as input to a deep learning framework to forecast the flow dynamics under various temporal and parameter conditions. The efficacy of the proposed approach is demonstrated through the analysis of one- and two-dimensional wildland fire models with varying reaction rates, and its error is compared with the error of other similar methods. The results indicate that the proposed approach yields reliable results within the percent range, while also enabling rapid prediction of system states within seconds.
A comprehensive review of optic disc segmentation methods in adult and pediatric retinal images: from conventional methods to artificial intelligence (CR-ODSeg-AP-CM2AI)
Authors: Bansal Avinash , Kubíček Jan , Penhaker Marek , Augustynek Martin 
Published: February 2025

Abstract
This review, titled CR-ODSeg-AP-CM2AI (Comprehensive Review of Optic Disc Segmentation in Adult and Pediatric Retinal Images: From Conventional Methods to Artificial Intelligence), explores optic disc segmentation techniques for adult and pediatric retinal images. It emphasizes the clinical implications of these techniques in diagnosing and monitoring retinal diseases across diverse populations. We systematically categorize each segmentation method, comparing traditional approaches with advancements in artificial intelligence (AI) to highlight innovative hybrid techniques that enhance segmentation accuracy and efficiency. This review also discusses evaluation metrics and the use of larger datasets to provide insights into the effectiveness and robustness of these methods.
Regional inequalities in air quality and health co-benefits due to climate change mitigation in the European electricity sector
Authors: Pehle Hannah , Sasse Jan-Philipp , Trutnevyte Evelina 
Published: February 2025

Abstract
Electricity supply transition to reach carbon neutrality in Europe is expected to bring air quality and health co-benefits, but their regional distribution has not been investigated in detail. This study quantifies these co-benefits for 250 European electricity scenarios in 2035 across 296 sub-national regions. The study links a spatially-explicit electricity sector model with an air quality and health impact model and then accounts for susceptibility and vulnerability of populations to adverse health effects. In case of low-carbon transition, direct PM2.5 concentrations attributable to European electricity generation in 2035 could be reduced by 45–99% compared to a system with the generation capacities of 2018. Depending on the system’s make-up, health co-benefits can vary significantly, as does their regional distribution. Focus on the minimum system costs leads to 15 times higher continent-wide excess deaths and to higher regional inequality than the scenario with minimum air pollutant emissions, which would almost entirely eliminate PM2.5-related mortality attributable to electricity generation. The most vulnerable regions (Balkans, Northern Germany, Southeast France, and the West Midlands in England) would benefit from higher air quality co-benefits than the continental average.
The factors affecting teachers’ adoption of AI technologies: A unified model of external and internal determinants
Authors: Hazzan-Bishara Areen , Kol Ofrit , Levy Shalom 
Published: February 2025

Abstract
This study examines factors influencing teachers' intention to adopt Generative AI technologies in education by extending the Technology Acceptance Model (TAM). The proposed comprehensive model incorporates both external factors (exposure to AI information, information credibility, and institutional support) and internal factors (intrinsic motivation and self-efficacy). A survey of 400 teachers reveals that teachers’ exposure to credible AI information positively influences perceptions of Generative AI usefulness, which ultimately impacts their intention to use AI. Importantly, institutional support has both direct and indirect effects on teachers' intention to use AI, with the indirect effect mediated by the internal factors of intrinsic motivation and self-efficacy. This research complements TAM theory by integrating psychological and contextual factors, offering a nuanced framework for understanding Generative AI adoption in educational settings. The findings suggest that for educational leaders and policymakers, developing strategies that allocate resources for infrastructure, technical support, and professional development—such as Generative AI training programs—will be crucial in driving Generative AI adoption among teachers. By addressing both external and internal determinants, this study provides a comprehensive perspective of the dynamics behind technology acceptance in the classroom.
The confluent Heun functions in black hole perturbation theory: a spacetime interpretation
Authors: Minucci Marica , Panosso Macedo Rodrigo 
Published: February 2025

Abstract
This work provides a spacetime interpretation of the confluent Heun functions within black hole perturbation theory (BHPT) and explores their relationship to the hyperboloidal framework. In BHPT, the confluent Heun functions are solutions to the radial Teukolsky equation, but they are traditionally studied without an explicit reference to the underlying spacetime geometry. Here, we show that the distinct behaviour of these functions near their singular points reflects the structure of key geometrical surfaces in black hole spacetimes. By interpreting homotopic transformations of the confluent Heun functions as changes in the spacetime foliation, we connect these solutions to different regions of the black hole’s global structure, such as the past and future event horizons, past and future null infinity, spatial infinity, and even past and future timelike infinity. We also discuss the relationship between the confluent Heun functions and the hyperboloidal formulation of the Teukolsky equation. Although neither confluent Heun form of the radial Teukolsky equation can be interpreted as hyperboloidal slices, this approach offers new insights into wave propagation and scattering from a global black hole spacetime perspective.
Long-term outcomes and re-intervention rates in women undergoing mri-guided focused ultrasound (mrgfus) for uterine fibroids: a 7-year follow-up study
Authors: Inbar Yael , Rabinovici Jaron , Sverdlove Rachael , Ziv-Baran Tomer , Machtinger Ronit 
Published: February 2025

Abstract

Purpose
To assess the long-term outcomes of MR-guided focused ultrasound (MRgFUS) for treating uterine fibroids, focusing on re-intervention rates, pregnancy outcomes, and the onset of menopause over a 7-year follow-up period.

Materials and Methods
We conducted a historical cohort study of 99 women with symptomatic uterine fibroids who underwent MRgFUS between 2013 and 2020 at a single tertiary medical center. Data collection included patient demographics, treatment details, and follow-up interviews. Re-intervention rates were evaluated using Kaplan–Meier curves and Cox regression analysis to identify predictors of further treatments, with a specific focus on age-related differences.

Results
Over a median follow-up of 6.1 years, 33.1% of women required re-intervention for persistent fibroid symptoms. The median patient's age was 43 years old. Women aged ≤ 43 years had significantly higher re-intervention rates than those aged 44 + years (47.5% vs. 16.7%, p = 0.005). Multivariable Cox regression identified age as the sole significant predictor of re-intervention (HR44+vs. <43 0.303 95% CI 0.128–0.714, p = 0.006). Sixteen women conceived after MRgFUS, resulting in 21 pregnancies, with 72.2% live births and a spontaneous miscarriage rate of 22.2%. The mean age of menopause was 51.4 years, similar to global averages.

Conclusions
MRgFUS is a practical, noninvasive option for treating symptomatic uterine fibroids. Older women show lower re-intervention rates. Pregnancies post-MRgFUS are possible, and the procedure does not appear to affect the onset of menopause. Age remains a crucial predictor for further re-intervention.
Impact of left atrial myopathy and post-ablation remodeling on quality of life: a DECAAF II sub-analysis
Authors: Bidaoui Ghassan , Feng Han , Chouman Nour , Assaf Ala , Lim Chanho , Younes Hadi , Bsoul Mayana , Massad Christian , Polo Francisco Tirado , Jia Yishi , Liu Yingshou , Hassan Abboud , Rittmeyer William , Mekhael Mario , Noujaim Charbel , Pandey Amitabh C. , Rao Swati , Kreidieh Omar , Marrouche Nassir F. , Donnellan Eoin 
Published: February 2025

Abstract

Background
Atrial fibrillation (AF) is associated with adverse remodeling of the left atrium (LA). The impact of the extent of atrial myopathy and post-ablation remodeling on quality-of-life (QoL) outcomes has not been studied.

Objective
The aim of our study was to investigate the association between atrial myopathy and post-ablation remodeling on quality-of-life outcomes in patients with persistent AF.

Methods
We conducted an analysis of DECAAF II participants who underwent late-gadolinium enhancement MRI (LGE-MRI) before and after AF ablation. We assessed atrial myopathy and post-ablation atrial remodeling, scar formation, and fibrosis coverage with ablation. QoL metrics were assessed using the Short Form Survey (SF-36) and Atrial Fibrillation Severity Scale (AFSS). Uni- and multivariable regression models were developed for this analysis.

Results
Six hundred thirteen patients with persistent AF were included in our analyses. At baseline, AFSS burden and total AFSS score were 18.94 ± 7.35 and 12.24 ± 8.17, respectively. Following ablation, all QoL and AFSS metrics improved in both the pulmonary vein isolation (PVI) and MRI-guided fibrosis ablation groups. On average, one unit of post-ablation reduction in left atrial volume index (LAVI) was associated with an improvement of 0.085 in total AFSS score (p = 0.001), 0.01 in shortness of breath with activity (p < 0.001), 0.15 in AF burden (p < 0.001), − 0.016 in global well-being (p = 0.018), 0.519 in health change (p < 0.001), 0.19 in vitality (vitality (p = 0.01), and 0.27 in physical functioning (p = 0.001). Baseline fibrosis and residual fibrosis post-ablation were associated with improved vitality and general health.

Conclusion
Atrial myopathy and post-ablation atrial remodeling significantly impact QoL in patients with persistent AF undergoing ablation.

Graphical abstract
A global review of the biology and ecology of the European perch, Perca fluviatilis
Authors: Ning Nathan , Barlow Chris , Baumgartner Lee J. , Bretzel Joachim B. , Doyle Katherine E. , Duffy Deanna , Price Amina , Vu An V. 
Published: February 2025

Abstract

Perca fluviatilis (the European perch) is one of the most common and well-studied freshwater fishes in the world, largely owing to its widespread distribution and popularity among anglers and aquaculturalists. It has been especially well-studied in its native ranges of Eurasia, but has received far less attention elsewhere. Here we review key aspects of the general biology and ecology of the European perch, by considering learnings from countries where it is native in addition to those where it has been introduced. Our review demonstrates that the European perch is a highly fecund, trophic generalist that can live in a wide range of habitats and withstand a wide range of physico-chemical conditions. The growth rates and sexual development of the European perch vary among geographical regions, largely due to differences in climatic conditions, with populations in warmer Southern Hemisphere regions tending to exhibit faster growth rates and attain sexual maturity at younger ages than populations occurring in most cooler Eurasian regions. Genetic differentiation has also been observed in native populations from different parts of Europe, although it remains unclear as to whether native and non-native populations differ genetically, and what the ecological implications of any such differences are. Future research should prioritise assessing both genetic and phenotypic differences between native and non-native populations, and determining the ecological implications of these differences. Such knowledge is crucial for informing European perch conservation and/or aquaculture management in countries where it is native; and invasive species management in countries where it has been introduced.
Proposal of Groundwater Governance Indexes: Application to Nine Spanish Aquifers
Authors: Custodio E. , Cabrera M. C. , Sánchez-García D. , de la Hera-Portillo A. , García-Aróstegui J. L. , Jódar J. , Martos-Rosillo S. , Puga L. O. , Queralt E. 
Published: February 2025

Abstract
Groundwater management and governance have properties related to the long renewal time, evapo-concentration processes in the soil and interaction with the rock, and dispersion, mixing and degradation of possible contaminants. Groundwater is part of the hydrologic balance, with specific properties and different behaviours from that of surface water, although there are interconnected. These differences also appear in other aspects related to economy, society, norms and administration, and to water ethics and morality. These differences are not always taken into account by water managers and decision makers. A methodology is being used to evaluate quantitatively groundwater management and sound governance. A score of themes are classified into aspects and categories, including hydrogeological knowledge, administration and socio-economics aspects. Three indexes are presented, the most developed of them correcting reserve depletion, unavoidable discharges and legal restrictions. The proposed indexes were tested in nine pilot areas in Spain, representing different circumstances, scales and environmental conditions. The discussion refers to aquifers and aquifer systems, considering the corresponding groundwater bodies and their quantitative and chemical status. It is not possible to condense the reality into one or a few figures. Comparisons have to be considered cautiously as a broad guide, with possible notable deviations, especially considering the groundwater average renewal time. There is not a well-defined correlation between groundwater management - governance evaluation and groundwater body’s status, but they have some common aspects that are relevant to improve groundwater management and governance.