bluuebunny/crossref_metadata_2025_split huggingface dataset:
European integration development in teacher training: educational outlook
Authors: Boichuk Y. , Rybalko L. 
Published: October 2023

The topicality of European integration processes in higher pedagogical education is determined by the requirements of society and the international community. They focus is at the teacher, able to work successfully in the educational workspace of a new format. Modus of educational process, high standards of cooperation and partnership, relations between participants of pedagogical interaction are given close attention. It is noted that educational cornerstones such as human health and happiness, humanism and democracy are predominant in scientific works. These crucial factors give a powerful impetus for transformational processes in higher education, that contribute to positive changes in education.
It is emphasized that the transformation of pedagogical education in Ukraine is determined by many factors. Among such factors one can name proper balance of theoretical and practical training, which is of prior importance, because the quality of higher education largely depends on it. Professional requirements shape the whole process of competitive teachers` training and can only be met by focusing on the practical component of teachers` work. Educational guidelines include the formulation of criteria for quality of pedagogical education, application of innovative approaches to the organization of educational process, development and updating of educational programs, cooperation with stakeholders, further collaboration with research institutions, public organizations.
European integration processes in higher pedagogical education encourage the participants of educational process to develop their own strong position regarding new changes. Authors of the article emphasize the necessity for compliance of the academic competencies stipulated in educational programs with the professional competences required by professional activity.
A special attention was paid to the individual educational trajectory of a student as a means of his/her professional growth and future career development. It is suggested that one should expand the list of educational programs in various specialties, to update the educational and methodological materials, as well as technical support of existing educational programs.
The ideas of learning through research in the educational environment were expanded in order to identify and develop research potential among the undergraduate and postgraduate students.
The history of the university as a brand: critical notes
Authors: Posokhov S. 
Published: October 2023

Attractiveness of an educational institution: constituents and trends: XXI International. science and practice conference, Kharkiv, 10th February 2023, Kharkiv Univ. оf Humanities “People’s Ukrainian Acad”
Theses are devoted to the definition and interpretation of the concept of the attractiveness of an educational institution in modern education. The components of the attractiveness of the educational institution are analyzed; global and local features of the construction and perception of the image of an educational institution; the mechanism of creating the attractiveness of an educational institution in conditions of uncertainty. Particular attention is paid to the influence of internal and external stakeholders on strengthening and broadcasting the image and authority of the educational institution.
The 5-factor modified frailty index as a prognostic factor of stereotactic radiosurgery for metastatic disease to the brain
Authors: Lucido Thomas , Rajkumar Sujay , Rogowski Brandon , Meinert Justin , Elhamdani Shahed , Liang Yun , Karlovits Stephen , Yu Alexander , Wegner Rodney E. , Shepard Matthew J. 
Published: October 2023

OBJECTIVE
Frailty, a state of increased vulnerability to adverse health outcomes, is associated with poor neurosurgical outcomes. The relationship between frailty and stereotactic radiosurgery (SRS) for brain metastases (BMs), however, has not been adequately described. In this study, the authors attempted to examine the connection between frailty and outcomes for patients receiving SRS for BMs.

METHODS
A single-center retrospective cohort study was performed. The 5-factor modified frailty index (mFI-5) was used to stratify patients into pre-frail (mFI-5 score 0–1), frail (mFI-5 score 2), and severely frail (mFI-5 score ≥ 3) cohorts at the time of SRS treatment. Both overall survival (OS) and progression-free survival (PFS) were evaluated. Factors associated with OS/PFS were assessed using Kaplan-Meier analysis and a Cox proportional hazards model.

RESULTS
Two hundred three patients met the inclusion criteria and received SRS to one or more BMs. Fifty-six patients (27.6%) received SRS as an adjuvant treatment. The 12-month OS and PFS rates were 58.6% and 45.5%, respectively. One hundred twenty-six patients (62.1%) were classified as pre-frail, 58 (28.6%) as frail, and 19 (9.4%) as severely frail. Significantly less OS was demonstrated in frailer groups (frail hazard ratio [HR] 3.14, p < 0.005; severely frail HR 3.13, p < 0.005). Compared with pre-frail patients, frail patients had shorter intervals of PFS (frail HR 2.05, p < 0.005). Five patients (2.5%) had symptomatic radiation necrosis (RN) and 60 (29.6%) required repeat radiation.

CONCLUSIONS
Higher frailty scores at the time of SRS treatment were predictive of shorter OS and PFS intervals.
A Comparative Move Analysis of Low and High-Impact Social Science Scopus Journal Articles Written by Reputable Indonesian Authors
Authors: Julieta Anggia Lyana , Kurniawan Eri , Lubis Arif Husen 
Published: October 2023

Producing research articles requires clearly, logically, rationally, and empirically substantiating complicated ideas. Regarding that, many professors struggle to have their articles published in highly regarded publications and require references; for instance, the rhetorical move pattern. Many studies have analyzed the rhetorical structure of articles, but few have investigated the rhetorical move of the research articles produced by lecturers by specifically comparing their publications in high-impact versus low-impact Scopus-indexed journals. Using a descriptive-comparative qualitative design, this study seeks to investigate the moves of low-impact and high-impact articles of the two social humanities lecturers of a state university in Indonesia. Eight articles were analyzed through the move framework proposed by Maswana (2015). The results revealed that the rhetorical moves from each section were organized with significant conformities and minor non-conformities.Especially, the authorsemphasized the goals, procedures, and outcomes of the publications in the abstract section. Furthermore, the writers provided references to the existing literature and the goal of the research to assist the reader in understanding the theory applied in the papers. On the other hand, deviations from the norm are displayed in the methodology section due to variations in how the study was conducted, particularly the data processing phase. The authors’ attention to conveying the research’s specific findings and their significance was in the findings and discussion section. The results of this study can be used as a reference for Indonesian researchers who are striving to publish papers in international journals toward a more visible and impactful publication.
Cracking the code of hatchery-based mass production of mola (Amblypharyngodon mola) seed for nutrition-sensitive aquaculture
Authors: Rajts Francois , Dubey Sourabh Kumar , Gogoi Kalpajit , Das Rashmi Ranjan , Biswal Saurava Kumar , Padiyar Arun Panemangalore , Rajendran Suresh , Thilsted Shakuntala Haraksingh , Mohan Chadag Vishnumurthy , Belton Ben 
Published: October 2023

IntroductionSmall indigenous fish species (SIS) can be particularly rich in micronutrients and make a crucial contribution toward improving human nutrition. The introduction of mola (Amblypharyngodon mola), an SIS, which is particularly rich in vitamin A, into smallholder carp aquaculture systems has been widely promoted over the past decade as a promising nutrition-sensitive innovation. However, standardized techniques for the hatchery mass production of mola do not yet exist. We hypothesized that the lack of commercial hatchery mass-production techniques for mola seed is the key barrier limiting potential for widespread adoption of carp–SIS polyculture.MethodsTo address this gap, we conducted breeding trials at a private hatchery in Odisha, India, from July to September 2022, to identify standardized methods for the hatchery-based mass production of mola seed. Breeding was induced using a synthetic gonadotropin-releasing hormone analog (SGnRHa) at 0.5 mL and 0.25 mL per kg of body weight of female fish and male fish, respectively. Fish spawned in double hapas in breeding tanks.ResultsThe average fertilization, spawning, and hatching rates over 10 breeding cycles were 81%, 82%, and 85%, respectively. A total of 8.5 million fertilized eggs and 6.4 million hatchlings were produced. The survival of fry during larval rearing trials at a stocking rate of 500 hatchlings/m2 was 58% after 22 days. The mola hatchlings and fry were sold to 29 farmers at prices comparable to those of Indian major carp.DiscussionThis article makes a unique contribution to the literature by documenting the entire process of hatchery-based mass mola seed production, including broodfish collection and maintenance, hormone dose optimization, breeding arrangements, breeder characteristics, breeding behavior and performance fecundity, larval rearing, and seed sales to farmers. This information is intended to serve as a protocol to be followed by any individual or institution with an interest in mola breeding and represents an important contribution to the development of nutrition-sensitive aquaculture.
Stem cell proliferation and differentiation during larval metamorphosis of the model tapeworm Hymenolepis microstoma
Authors: Montagne Jimena , Preza Matías , Koziol Uriel 
Published: October 2023

BackgroundTapeworm larvae cause important diseases in humans and domestic animals. During infection, the first larval stage undergoes a metamorphosis where tissues are formed de novo from a population of stem cells called germinative cells. This process is difficult to study for human pathogens, as these larvae are infectious and difficult to obtain in the laboratory.MethodsIn this work, we analyzed cell proliferation and differentiation during larval metamorphosis in the model tapeworm Hymenolepis microstoma, by in vivo labelling of proliferating cells with the thymidine analogue 5-ethynyl-2′-deoxyuridine (EdU), tracing their differentiation with a suite of specific molecular markers for different cell types. ResultsProliferating cells are very abundant and fast-cycling during early metamorphosis: the total number of cells duplicates every ten hours, and the length of G2 is only 75 minutes. New tegumental, muscle and nerve cells differentiate from this pool of proliferating germinative cells, and these processes are very fast, as differentiation markers for neurons and muscle cells appear within 24 hours after exiting the cell cycle, and fusion of new cells to the tegumental syncytium can be detected after only 4 hours. Tegumental and muscle cells appear from early stages of metamorphosis (24 to 48 hours post-infection); in contrast, most markers for differentiating neurons appear later, and the detection of synapsin and neuropeptides correlates with scolex retraction. Finally, we identified populations of proliferating cells that express conserved genes associated with neuronal progenitors and precursors, suggesting the existence of tissue-specific lineages among germinative cells. DiscussionThese results provide for the first time a comprehensive view of the development of new tissues during tapeworm larval metamorphosis, providing a framework for similar studies in human and veterinary pathogens.
Genomic variation associated with cardiovascular disease progression following preeclampsia: a systematic review
Authors: Krishnamurthy Gayathry , Nguyen Phuong Tram , Tran Bao Ngoc , Phan Hoang T. , Brennecke Shaun P. , Moses Eric K. , Melton Phillip E. 
Published: October 2023

BackgroundWomen with a history of preeclampsia (PE) have been shown to have up to five times the risk of developing later-life cardiovascular disease (CVD). While PE and CVD are known to share clinical and molecular characteristics, there are limited studies investigating their shared genomics (genetics, epigenetics or transcriptomics) variation over time. Therefore, we sought to systematically review the literature to identify longitudinal studies focused on the genomic progression to CVD following PE.MethodsA literature search of primary sources through PubMed, Scopus, Web of Science and Embase via OVID was performed. Studies published from January 1, 1980, to July 28, 2023, that investigated genomics in PE and CVD were eligible for inclusion. Included studies were screened based on Cochrane systematic review guidelines in conjunction with the PRISMA 2020 checklist. Eligible articles were further assessed for quality using the Newcastle-Ottawa scale.ResultsA total of 9,231 articles were screened, with 14 studies subjected to quality assessment. Following further evaluation, six studies were included for the final review. All six of these studies were heterogeneous in regard to CVD/risk factor as outcome, gene mapping approach, and in different targeted genes. The associated genes were RGS2, LPA, and AQP3, alongside microRNAs miR-122-5p, miR-126-3p, miR-146a-5p, and miR-206. Additionally, 12 differentially methylated regions potentially linked to later-life CVD following PE were identified. The only common variable across all six studies was the use of a case-control study design.ConclusionsOur results provide critical insight into the heterogeneous nature of genomic studies investigating CVD following PE and highlight the urgent need for longitudinal studies to further investigate the genetic variation underlying the progression to CVD following PE.
Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice
Authors: Yue Ruichao , Wei Xiaoyuan , Hao Liuyi , Dong Haibo , Guo Wei , Sun Xinguo , Zhao Jiangchao , Zhou Zhanxiang , Zhong Wei 
Published: October 2023

BackgroundThe hepatoprotective effect of interleukin 22 (IL-22) has been reported in several models of liver injuries, including alcohol-associated liver disease (ALD). However, the intestinal role of IL-22 in alcoholic hepatitis remains to be elucidated.MethodsIntestinal IL-22 levels were measured in mice fed with alcohol for 8 weeks. IL-22 was then administered to alcohol-fed mice to test its protective effects on alleviating alcoholic hepatitis, focusing on intestinal protection. Acute IL-22 treatment was conducted in mice to further explore the link between IL-22 and the induction of antimicrobial peptide (AMP). Intestinal epithelial cell-specific knockout of signal transducer and activator of transcription 3 (STAT3) mice were generated and used for organoid study to explore its role in IL-22-mediated AMP expression and gut barrier integrity.ResultsAfter alcohol feeding for 8 weeks, the intestinal levels of IL-22 were significantly reduced in mice. IL-22 treatment to alcohol-fed mice mitigated liver injury as indicated by normalized serum transaminase levels, improved liver histology, reduced lipid accumulation, and attenuated inflammation. In the intestine, alcohol-reduced Reg3γ and α-defensins levels were reversed by IL-22 treatment. IL-22 also improved gut barrier integrity and decreased endotoxemia in alcohol-fed mice. While alcohol feeding significantly reduced Akkermansia, IL-22 administration dramatically expanded this commensal bacterium in mice. Regardless of alcohol, acute IL-22 treatment induced a fast and robust induction of intestinal AMPs and STAT3 activation. By using in vitro cultured intestinal organoids isolated from WT mice and mice deficient in intestinal epithelial-STAT3, we further demonstrated that STAT3 is required for IL-22-mediated AMP expression. In addition, IL-22 also regulates intestinal epithelium differentiation as indicated by direct regulation of sodium-hydrogen exchanger 3 via STAT3.ConclusionOur study suggests that IL-22 not only targets the liver but also benefits the intestine in many aspects. The intestinal effects of IL-22 include regulating AMP expression, microbiota, and gut barrier function that is pivotal in ameliorating alcohol induced translocation of gut-derived bacterial pathogens and liver inflammation.
Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics
Authors: Gómez-Varela David , Xian Feng , Grundtner Sabrina , Sondermann Julia Regina , Carta Giacomo , Schmidt Manuela 
Published: October 2023

IntroductionMetaproteomics is a rapidly advancing field that offers unique insights into the taxonomic composition and the functional activity of microbial communities, and their effects on host physiology. Classically, data-dependent acquisition (DDA) mass spectrometry (MS) has been applied for peptide identification and quantification in metaproteomics. However, DDA-MS exhibits well-known limitations in terms of depth, sensitivity, and reproducibility. Consequently, methodological improvements are required to better characterize the protein landscape of microbiomes and their interactions with the host.MethodsWe present an optimized proteomic workflow that utilizes the information captured by Parallel Accumulation-Serial Fragmentation (PASEF) MS for comprehensive metaproteomic studies in complex fecal samples of mice.Results and discussionWe show that implementing PASEF using a DDA acquisition scheme (DDA-PASEF) increased peptide quantification up to 5 times and reached higher accuracy and reproducibility compared to previously published classical DDA and data-independent acquisition (DIA) methods. Furthermore, we demonstrate that the combination of DIA, PASEF, and neuronal-network-based data analysis, was superior to DDA-PASEF in all mentioned parameters. Importantly, DIA-PASEF expanded the dynamic range towards low-abundant proteins and it doubled the quantification of proteins with unknown or uncharacterized functions. Compared to previous classical DDA metaproteomic studies, DIA-PASEF resulted in the quantification of up to 4 times more taxonomic units using 16 times less injected peptides and 4 times shorter chromatography gradients. Moreover, 131 additional functional pathways distributed across more and even uniquely identified taxa were profiled as revealed by a peptide-centric taxonomic-functional analysis. We tested our workflow on a validated preclinical mouse model of neuropathic pain to assess longitudinal changes in host-gut microbiome interactions associated with pain - an unexplored topic for metaproteomics. We uncovered the significant enrichment of two bacterial classes upon pain, and, in addition, the upregulation of metabolic activities previously linked to chronic pain as well as various hitherto unknown ones. Furthermore, our data revealed pain-associated dynamics of proteome complexes implicated in the crosstalk between the host immune system and the gut microbiome. In conclusion, the DIA-PASEF metaproteomic workflow presented here provides a stepping stone towards a deeper understanding of microbial ecosystems across the breadth of biomedical and biotechnological fields.
Multimodal intelligent logistics robot combining 3D CNN, LSTM, and visual SLAM for path planning and control
Authors: Han Zhuqin 
Published: October 2023

IntroductionIn today's dynamic logistics landscape, the role of intelligent robots is paramount for enhancing efficiency, reducing costs, and ensuring safety. Traditional path planning methods often struggle to adapt to changing environments, resulting in issues like collisions and conflicts. This research addresses the challenge of path planning and control for logistics robots operating in complex environments. The proposed method aims to integrate information from various perception sources to enhance path planning and obstacle avoidance, thereby increasing the autonomy and reliability of logistics robots.MethodsThe method presented in this paper begins by employing a 3D Convolutional Neural Network (CNN) to learn feature representations of objects within the environment, enabling object recognition. Subsequently, Long Short-Term Memory (LSTM) models are utilized to capture spatio-temporal features and predict the behavior and trajectories of dynamic obstacles. This predictive capability empowers robots to more accurately anticipate the future positions of obstacles in intricate settings, thereby mitigating potential collision risks. Finally, the Dijkstra algorithm is employed for path planning and control decisions to ensure the selection of optimal paths across diverse scenarios.ResultsIn a series of rigorous experiments, the proposed method outperforms traditional approaches in terms of both path planning accuracy and obstacle avoidance performance. These substantial improvements underscore the efficacy of the intelligent path planning and control scheme.DiscussionThis research contributes to enhancing the practicality of logistics robots in complex environments, thereby fostering increased efficiency and safety within the logistics industry. By combining object recognition, spatio-temporal modeling, and optimized path planning, the proposed method enables logistics robots to navigate intricate scenarios with higher precision and reliability, ultimately advancing the capabilities of autonomous logistics operations.
Dietary selenium intake among Ethiopian children in areas known for selenium spatial variability
Authors: Hailu Kaleab , Joy Edward J. M. , Ferguson Elaine L. , Bailey Elizabeth H. , Wilson Lolita , Davis Kenneth , Broadley Martin R. , Gashu Dawd 
Published: October 2023

IntroductionThere is spatial variability of selenium (Se) in soil and crops in Ethiopia. We assessed the Se content of food items, breast milk, and urine among infants in Ethiopia from two areas with contrasting Se concentrations in soils.MethodsDietary Se intakes among children (6–23 months) were evaluated using a weighed food record on two non-consecutive days. Also, spot urine samples from children and breast milk samples from their mothers were collected to determine Se concentration. Selenium concentrations in the samples were analyzed using an inductively coupled plasma mass spectrometer (ICP-MS).ResultsInjera (prepared from teff and mixtures of other cereals) with a legume-based stew were the most frequently consumed foods by the children in both areas, followed by pasta. Overall, the Se concentration (mean ± SD) of food items, breast milk (12.2 ± 3.9 μg/L vs. 3.39 ± 1.5 μg/L), and urine samples (22.5 ± 11.5 μg/L vs. 3.0 ± 1.9 μg/L) from East Amhara were significantly higher than the corresponding samples from West Amhara (p&lt; 0.001). The total Se intakes by the study children from East Amhara and West Amhara were 30.2 [IQ25%, 14.2; IQ75%, 54.1] and 7.4 [IQR25%, 4.2; IQ75%, 10.6] μg day–1, respectively; 31.5% of children from East Amhara and 92% of children from West Amhara were at risk of inadequate Se intakes. Urinary Se excretion accounted for 53 and 39% of daily dietary Se intake in East Amhara and West Amhara, respectively. Dietary Se intake was positively correlated with urinary Se excretion in East Amhara (r= 0.56;p&lt; 0.001) but not among samples from West Amhara (r= 0.16;p≥ 0.05), suggesting greater physiological Se conservation in a state of deficiency.ConclusionThere is spatial variability of Se in foods, breast milk, and urine in Ethiopia, suggesting the need for implementation of targeted agronomic interventions that enhance Se concentrations in the edible portion of plant foods.