bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Studies on Epidermal Mucus of Fish Anabas Testudineus
Authors: Bose M.T. Jagannath , Velmurugan B. , Poornima D. , Vineetha V.K. , Banu N. Samima, A. Ayisha 
Published: October 2023

The present investigation was conducted to find out the antimicrobial, hemolytic activity and protein content of fish epidermal mucus and their chemical constituents from Anabas testudineus. The in vitro hemolytic activity were analyzed and the antimicrobial activity against human pathogens (Bacteria) were determined by agar well diffusion methods. Epidermal mucus sample protein was analyzed by (Thin layer chromatography and SDS-PAGE). Totally thirteen human pathogens were tested against the fish mucus. Out of thirteen pathogens five pathogens have proved to be sensitive to the mucus. The average value of maximum zone of inhibition was observed against K. pneumonia (15.17±0.09mm) > P. vulgaris (13.2±0.17mm) > E. lentum (12.43±0.18mm) > MRSA (11.37±0.32mm) > S. aureus (10.5±0.11mm). The percentage of haemolysis for lyophilized sample shows more hemolytic activity. The amount of protein present in the mucus for Lyophilized sample: 3.61 g/dL, for Rotavac sample: 1.08 g/dL. The present inspection were revealed that positive progresses in the fish mucus extracts hostile to human pathogen (Bacteria) and the hemolytic activity, also the simple population of proteins (SDS PAGE) and the (TLC) reveals the presence of amino acids and peptides. Further efforts are required for the isolation of the active antimicrobial compounds in order to establish their possible applications.
Changes in the financing of medical institutions of Ukraine and the efficiency of using their assets
Authors: Romanchenko Natalia , Kozhemiakina Tetiana 
Published: October 2023

The purpose of the study is to analyze the transformational changes that have taken place in the financing of the health care sector and the availability and regional distribution of assets of health care enterprises. The study is based on data from the Ministry of Finance, the Ministry of Health of Ukraine and the National Health Service of Ukraine.The article analyzes the expenditures of the Consolidated Budget of Ukraine and health care expenditures. It was determined that after the start of the medical reform, there was a trend towards an increase in the share of health care costs in the total expenditure part of the Consolidated Budget of Ukraine.Based on the analysis of the data of the National Health Service of Ukraine, the number and distribution of costs among medical providers according to the level of medical care were determined. The presence and distribution of the medical industry’s assets among hospitals in the regions of Ukraine were analyzed. It was found that, during 2022, enterprises in the healthcare sector of Ukraine significantly increased their assets.To assess the effectiveness of the industry’s use of assets, the indicator of “return on assets” of health care facilities based on the amount of payments from the National Health Service of Ukraine for the provided medical services was used. The amount of payment per patient was analyzed based on the number of declarations signed by patients. The influence of the migration factor as a result of the war on the activities of health care institutions was determined.Conclusions were made regarding the need for a more even distribution of assets of the medical industry to increase the efficiency of their use. The city of Kyiv’s medical assets need more complete use.Based on the results of the study, conclusions were made about the positive impact of the implementation of the reform on the financing of the medical industry. It was noted that further research in this area can be aimed at identifying factors influencing the effectiveness of the use of the assets of Ukraine’s medical institutions and finding reserves for increasing the efficiency of their use.It is emphasized that when making calculations, standard approaches to evaluating efficiency should be transformed, taking into account the specifics of the medical field so that they can adequately reflect the industry’s economic situation.
JEL classification: H51, I18
The impact of monetary policy during the legal regime of martial law on the Ukrainian labor market
Authors: Donkohlova Tetiana 
Published: October 2023

The purpose of this research is to conduct an in-depth analysis of the monetary policy influence during the period of martial law on the state of the labor market and welfare of the population in Ukraine. The article examines the effects of military actions on the workforce, employment sectors, and briefly outlines the key actions taken by the National Bank of Ukraine (NBU) to stabilize the macroeconomic situation in the country, mitigate inflationary pressure, and counter capital outflows.Based on available statistical data and expert assessments of the labor market in Ukraine following the full-scale invasion, the effectiveness of monetary mechanisms, including the temporary shift from inflation targeting to exchange rate fixing, was analyzed. The conducted analysis confirmed that despite timely adaptive changes in monetary policy by the regulator, the effectiveness of the monetary transmission mechanism during wartime remains low. The decline in real production, reduced confidence in the national currency, and the initiation of government spending financed through monetary emission resulted in an excess liquidity situation in the economy, leading to diminished effectiveness of the monetary transmission mechanism. As a result, controlling inflation levels and inflation expectations during the period of martial law cannot be fully ensured by the National Bank of Ukraine.Moreover, the analysis of forced emigration dynamics during the Russian invasion also revealed that high uncertainty levels deter refugees from returning to Ukraine and incentivize them to spend earned income in host countries. Despite the unprecedented wave of emigration, the increase in private remittances from abroad remains marginal. Thus, a priority task for the government should be to develop strategies of financial and social incentives to encourage the return of the working population and facilitate Ukraine’s post-war reconstruction.
JEL classіfіcatіon: E58, F24, G28, J21
Hacia una Unión Europea “de” las personas. Sobre la propuesta de la Comisión Europea sobre la protección de adultos vulnerables en situaciones transfonterizas
Authors: González Marimón María 
Published: October 2023

El presente artículo analiza la Propuesta de la Comisión Europea de un Reglamento
sobre la protección de los adultos vulnerables en situaciones transfronterizas. En la actualidad, en la Unión Europea encontramos un panorama de fragmentación y diversidad normativa en relación con la protección de adultos vulnerables, tanto en las normas sustantivas como en las normas de Derecho Internacional privado. Con una ambiciosa apuesta de combinar un nuevo Reglamento con el ya existente Convenio de La Haya del 2000 sobre protección internacional de adultos vulnerables, el legislador de la UE pretende hacer frente a la actual inseguridad jurídica a la que se ven abocados los adultos vulnerables en situaciones transfronterizas, ofreciendo una armonización que redunde en adecuada protección de sus derechos fundamentales en el seno de la Unión.
La causa de exoneración de los riesgos por desarrollo en el nuevo paradigma digital
Authors: Izquierdo Grau Guillem 
Published: October 2023

Uno de los pilares sobre los cuales se asentó la legislación sobre responsabilidad por productos es la exoneración de responsabilidad del productor por los riesgos del desarrollo. En virtud de tal causa de exoneración de responsabilidad, el productor no responde de los daños causados al perjudicado si en el momento en que el producto fue puesto en circulación, el estado de los conocimientos científicos y técnicos no permitía descubrir la existencia del defecto. La Propuesta de Directiva elaborada por la Comisión Europea, que fue publicada el día 28 de septiembre de 2022, sigue previendo en su artículo 10.1.e) la causa de exoneración por responsabilidad de los riesgos por desarrollo. A este particular, la Propuesta de Directiva dedica el considerando núm. 39 que introduce algunos requisitos para la apreciación de tal causa de exoneración de responsabilidad.
No obstante, a pesar de este reconocimiento, ¿tiene encaje esta causa de exoneración de responsabilidad del productor en el paradigma digital? ¿cómo puede aplicarse a los daños provocados por defectos en productos con elementos digitales que incorporan inteligencia artificial?
Estudio de Derecho español, inglés y comunitario sobre la extensión al tercero perjudicado del convenio arbitral y de ley aplicable del seguro marítimo de responsabilidad civil
Authors: Sierra Noguero Eliseo 
Published: October 2023

Se analizan los principales casos judiciales británicos; españoles y comunitarios que han debido resolver si las habituales cláusulas de ley aplicable y convenio arbitral de los seguros de protección e indemnización son o no oponibles al tercero perjudicado por las acciones del armador asegurado. En Derecho británico; se considera oponible; al igual que en Derecho español desde la sentencia “Seabank” de 2003. No obstante; el Tribunal de Justicia de la Unión Europea en el caso “Prestige” de 2022 considera que el convenio arbitral no puede ser oponible al tercero perjudicado que ejerce la acción directa contra el asegurador de responsabilidades civiles marítimas.
Negar y establecer la paternidad de lege lata según el DIP rumano vs. de lege ferenda según el Reglamento del Consejo en materia de filiación y sobre la creación de un certificado de filiación europeo
Authors: Aniţei Nadia-Cerasela , Dornean Păunescu Raluca Laura 
Published: October 2023

El estudio presenta un análisis del procedimiento para negar la paternidad y establecer la paternidad, tal como se llevan a cabo actualmente en Rumania según el derecho internacional privado rumano, respectivamente en antítesis, los procedimientos para establecer la filiación de lege ferenda según la Propuesta de un Reglamento del Consejo sobre jurisdicción, ley aplicable, reconocimiento de resoluciones judiciales y aceptación de documentos auténticos en materia de filiación y sobre la creación de un certificado europeo de filiación.
Ab initio, se presentan aclaraciones preliminares sobre las disposiciones del derecho internacional privado rumano con referencia a la filiación, la filiación del hijo del matrimonio en el derecho internacional privado rumano, la ley aplicable al hijo nacido dentro del matrimonio, la forma de interpretar las disposiciones del Código Civil rumano sobre la determinación de la ley aplicable a la filiación del niño nacido dentro del matrimonio, el alcance de la ley de filiación, la ley aplicable a la legitimación de un niño nacido antes del matrimonio, respectivamente propuestas de lege ferenda.
A continuación, el artículo aborda las referencias relativas a la filiación del niño fuera del matrimonio en el derecho internacional privado rumano, respectivamente sede legal de las disposiciones relativas a la filiación del niño fuera del matrimonio en el derecho internacional privado rumano, la ley
aplicable a la filiación del hijo fuera del matrimonio, el campo de la ley aplicable a la filiación del hijo fuera del matrimonio, así como la ley aplicable a la filiación como resultado de la reproducción humana con un tercer donante, respectivamente la ley aplicable a la filiación como resultado de la reproducción humana con un tercer donante en el caso de un hijo nacido dentro del matrimonio, así como la ley aplicable a la filiación como resultado de la reproducción humana con un tercer donante en el caso de un hijo extramatrimonial.
A continuación, los autores presentan las debidas aclaraciones sobre la dicotomía de las disposiciones del derecho internacional privado rumano y la correspondencia con el reglamento propuesto por el Consejo sobre la filiación, señalando la jurisdicción, la ley aplicable y el reconocimiento.
En el corolario, se destaca un estudio de caso, un elemento de jurisprudencia, que denota la jurisprudencia en Rumanía, respectivamente, la hipótesis de solución de lege ferenda de la situación, en virtud de la propuesta de Reglamento en materia de filiación.
Angela Di Stasi, Maria Caterina Baruffi, Lina Panella. Cittadinaza europea e cittadinanza nazionale. Sviluppi normativi e approdi giurisprudenziali
Authors: Virzo Roberto 
Published: October 2023

Este artículo reseña: Angela Di Stasi, Maria Caterina Baruffi, Lina Panella. Cittadinaza europea e cittadinanza nazionale. Sviluppi normativi e approdi giurisprudenziali. A cura di. Napoli, Editoriale Scientifica, 2023, 628 p.
Study of a solid-state vibrating gyroscope in the mode of determining the true azimuth of a given direction and the latitude of the location of the object
Authors: Zamorskyi Oleksander , Golovach Serhii , Strokach Grygorii 
Published: October 2023

The accuracy of determining navigation parameters, the true azimuth of the specified direction, and the latitude of the object's location is being investigated using a Coriolis vibratory gyroscope with a cylindrical metal resonator as a sensitive element of the tactical accuracy class for stabilization systems and control of moving objects. The study used a scheme of a scanning single-component analytical gyroscope compass with the ability to provide vertical direction scanning during the input axis of the angular velocity sensor – the Coriolis vibratory gyroscope. The obtained root-mean-square value of 0,32°·secφ of the error in determining the true azimuth of the specified direction under conditions close to normal confirms the potential possibility of using a Coriolis vibratory gyroscope with a cylindrical metal resonator in orientation and attitude heading reference systems. The average error of 0,34 in determining the latitude of the object's location obtained under the same conditions, with a root-mean-square value of of it is scatter, correlates with the expected result.
Knowledge-based system for aircraft design
Authors: Konotop Dmytro 
Published: October 2023

This article, based on the analysis and the theoretical approaches of the subject area "Design of aircraft at the sketch stage" proposed a method of aircraft design, which allows mathematically sufficiently effective implementation of the process of aircraft construction, on the example of aircraft using an ontological approach. The approach allows us to identify ways to formalize the two main situations that occur in the design of aircraft: sequential complication and refinement (descending design) and consistent simplification (ascending design). The proposed technology allows to significantly reducing the total design time of the aircraft through the use of several levels of model decomposition.
The application of the ontological approach facilitates the design process, allows solving the main tasks of modern design at different stages of aircraft creation, to coordinate the parallel work of designers on the project.
The main advantages of using the ontology design of the developed aircraft are:
1) effective compact presentation of the knowledge system of the subject area "Design of aircraft" on the basis of modern information technologies (specification and conceptualization);
2) search for information in the system of knowledge of the obtained ontology (obtaining reference and educational information);
3) formulation and solution of the necessary applied tasks within the given subject area (tasks of weight design, centering of the aircraft);
4) development of the system and acquisition of new knowledge or streamlining of existing ones, verification of their consistency, correction of the aircraft design tree.
PRINSIP KECUKUPAN MATERI PEMBELAJARAN TERHADAP MAHASISWA SEMESTER 3 PAI UII DALAM MATA KULIAH METODOLOGI PENELITIAN PENDIDIKAN TAHUN AJARAN 2022- 2023
Authors: Almuhaimin  , Alam Al Akbar  , Edi Safitri  
Published: October 2023

Riset ini ingin menemukan sejauh mana Prodi Pendidikan Agama Islam mempertimbangkan prinsip kecukupan pembelajaran dalam kebijakan akademiknya serta mengetahui penyebab adanya mahasiswa yang belum memenuhi prinsip kecukupan materi pembelajaran bisa mengambil matakuliah lanjutan. Pentingnya riset ini adalah untuk memeberikan kontribusi dalam bidang keilmuan, khususnya dalam ilmu penerapan kurikulum mengenai prinsip kecukupan pembelajaran yang diterapkan prodi pendidikan agama islam dalam melaksanakan rancangan pembelajarannya. Riset ini adalah riset kualitatif dengan teknik pengumpulan data menggunakan metode kualitatif. Teknik pengumpulan data megunakan teknik Observasi, wawancara dan dokumentasi. Riset ini ingin menjawab dua hal penting yaitu : cakupan kedalaman materi dan ketepatan prosedur. Berdasarkan penelitian di temukan bahwa pada tataran implementasi terjadi ketidakselarasan prinsip kecukupan materi pembelajaran yang di berikan kepada mahasiswa semester 3 Prodi PAI pada tahun ajaran tersebut. Oleh sebabnya pada tataran implementasi prinsip kecukupan materi pembelajaran tersebut perlu di kaji ulang. Adapun penyebab terjadi ketidakselarasan adalah di karenakan empat hal utama yaitu: Kesalahan prodi dalam mempertimbangkan materi pembelajaran serta mata kuliah yang akan di berikan, sistem KRS, peralihan kurikulum serta keterlambatan sosialisasi
Sistem Ekonomi Liberal pada Masa Kolonial di Pedesaan
Authors: Tri Sela Andani  , Saputra Muhammad Ridho , Yustina Sri Ekwandari  
Published: October 2023

Abstract
In 1870 was a final stage of forced cultivation. An important law was passed that year, namely the agrarian lawa, wich was to regulate private entrepreneurs in acquiring land. And also issued sugar law that regulates the transfer of sugar companies into the hands of the private sevctor. With the end of this forced cultivation, then the implementation in Indonesia of a liberal colonial politics or liberal economy. The liberal economic system is an economic system wich in its implementation gives freedom to its people so that they can carry out economic activities or can run a business and will get as much profit as possible. This liberal economic system also highly upholds ownership rights to an individual and in market competition. With the liberation of economic life from all interventions to promote government and eliminate coercive elements of economic life the economic development of the Duts East Indies. This liberal era led to deeper economic penetration into the life of Indonesia society, especially in Java. The Javanese indigeneous people began to lease land to private Dutch parties.
Keywords: Liberal economy, colonial period, forced cultivation rural in Java.

Abstrak
Pada tahun 1870 merupakan sebuah tahapan akhir dari adanya tanam paksa. Undang-undang penting disahkan pada tahun itu, yaitu undang-undang agrarian, yaitu untuk mengatur para pengusaha swasta untuk mendapatkan tanah. Dan juga dikeluarkannya hukum gula yang mengatur pengalihan perusahaan gula ketangan para swasta. dengan aberakhirnya tanam paksa ini, kemudian diterapkannya di Indonesia sebuah politik kolonial liberal atau ekonomi liberal. Sistem ekonomi liberal merupakan sebuah sistem ekonomi yang dimana dalam pelaksanaanya memberikan sebuah kebebasan terhadap masyarakatnya agar dapat melakukan aktivitas ekonomi atay dapat menjalankan usaha dan akan mendapatkan keuntungan yang sebanyak-banyaknya. Sistem ekonomi liberal ini juga sangat menjunjung tinggi hak kepemilikan pada suatu individu dan dalam persainagn pasar. Dengan adanya pembebasan kehidupan ekonomi dari segala intervensi untuk mempromosikan pemerintah dan menghilangkan unsur-unsur koersif kehidupan ekonomi perkembangan ekonomi Hindia-Belanda. Pada era liberal ini menyebabkan penetrasi ekonomi yang lebih dalam kedalam kehidupan pada masyarakat Indonesia, khususnya di Jawa. Para masyarakat penduduk pribumu Jawa mereka mulai menyewakan tanah kepada pihak swasta Belanda.
Kata kunci: Ekonomi liberal, masa kolonial, tanam paksa, pedesaan di Jawa
Prediction of MicroRNAs Involved in Lignan and Cyanogenic Glycosides Biosynthesis of Flax (Linum usitatissimum L.)
Authors: Harenčár Ľubomír , Ražná Katarína 
Published: October 2023

Abstract
MicroRNAs are short non-coding single-stranded molecules RNA with length 20–24 nucleotides that are of great importance to negative regulation of gene expression. In organisms, they participate in a wide spectrum of biological processes including differentiation, development, cell signalization, metabolism, reaction to biotic and abiotic stresses, reproduction, and many others. Lignans have a huge therapeutic potential thanks to their antioxidant, anti-inflammatory, anticancer, antidiabetic, estrogenic and antiestrogenic features. Major role of cyanogenic glycosides lies in a releasing of hydrogen cyanide (HCN). Together with lignans play various roles in plant defence processes. Next generation sequencing blazes a trail in new “omic” approaches such as genomics, transcriptomics, proteomics, metabolomics, epigenetics even panomics while an individual field of study is bioinformatics that develops computational algorithms for processing of these valuable data. In addition, a simple and often free of charge access to big amount of data as well as to bioinformatic algorithms and computational systems enable a comparison of individual genomes, transcriptomes, proteomes or metabolomes and an identification of conserved biosynthetic pathways and regulating elements in many organisms at the same time. The main aim of this research was to predict microRNA families involved in metabolic pathway of flax lignans and cyanogenic glycosides (Linum usitatissimum L.). There have been identified 15 lignan and 10 cyanogenic glycosides regulating microRNA families occurred in the flax genome whereas 6 microRNA families are regulating both pathways.
m7G Methylation-Related Genes Impact Prognosis and Tumor Immune Microenvironment in bladder cancer
Authors: Shen Liliang , Chen Haotian , Zhang Zhijin , Tang Yuqi , Hu Wenhao , Wang Xuhui , Wang Kaiyun , Zhang Yi , Chen Yifan 
Published: October 2023

Abstract
Objective: N7-methylguanosine (m7G) is an important biological process of post-transcriptional modification. In recent years, the role of m7G in tumorigenesis and development has received more and more attention. However, the mechanism of m7G in bladder cancer and its impact on the immune microenvironment is still unclear.
Methods: M7G-related genes were screened out from TCGA database. Through the LASSO regression analysis, the m7G-score was constructed. A nomogram incorporating m7G-score and clinicopathological characteristics was also constructed. Then, we evaluated the effect of m7G-score on TME and the relevance of immune cells. We also divided the cohort into 2 m7G-related patterns using unsupervised clustering. And the effect of high and low m7G-score on the drug sensitivity of patients by the “pRRophetic” package.
Results: We established an 11-gene m7gscore based on training set and divided it into high and low-risk groups according to the median score. Further, m7Gscore also has good predictive ability in the test set and total cohort. A prognostic nomogram was constructed by combining m7gscore and clinicopathological features. The analysis of the TME showed that the high-risk group had more infiltrating immune cells and immune function, and were more sensitive to chemotherapy and immunotherapy. In addition, patients were divided into two patterns using unsupervised clustering and immune differences between the two groups were investigated.
Conclusion: This study also evaluated the role of the m7G-score in predicting patient prognosis, immune microenvironment landscape, and drug sensitivity, providing new insights into the treatment of bladder cancer from the level of post-transcriptional modifications.