bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of cooking on the protein quality of Russet potatoes
Authors: Bailey Taryn , Franczyk Adam J. , Goldberg Erin M. , House James D. 
Published: October 2023

AbstractDespite being low in crude protein, on a fresh weight basis, given their overall contribution to the North American diet, potatoes contribute approximately 2%–4% of the population's protein intake. However, the quality of the protein remains ill‐defined. To that end, Russet potatoes were secured and subjected to various cooking conditions (raw [control], boiled, baked, microwaved, and fried [3, 6, and 9 min]) to determine the impact of cooking method on protein quality, as determined by amino acid score (AAS) and indices of in vivo true fecal protein digestibility (TFPD%; rodent bioassay) and in vitro protein digestibility (pH‐drop, pH‐Stat, and simulated gastrointestinal digestion both static and dynamic). The AAS of raw Russet potatoes was 0.67 ± 0.01, with histidine being the limiting AA. Frying led to a significant reduction in the AAS, however, other cooking methods yielded similar results to the raw control. The TFPD% of raw potato was low (40.5% ± 3.9%) and was significantly enhanced to over 80% with all cooking methods. Similar patterns were observed with all in vitro measures, however, all methods yielded higher values for the raw control samples. Final protein digestibility‐corrected AAS (PDCAAS; product of AAS and TFPD%) values ranged from 0.27 (raw) to a high of 0.57 (boiled), with cooked values being comparable to other plant‐based protein sources, including grains, and some nuts and pulses. In vitro PDCAAS values followed similar trends. This study defined the protein quality of cooked Russet potatoes and provides data for use in defining the quality of total protein consumed in the North American diet.
Sustainable Engineering Design in Education: A Pilot Study of Teaching Right‐to‐Repair Principles through Project‐Based Learning
Authors: Fishlock Sam , Thompson Matthew , Grewal Anoop 
Published: October 2023

AbstractOver 60 million tons of E‐waste is expected to be generated in 2023, with associated significant impacts on health and the environment. To reduce the number of products sent to landfills, “Right to Repair” (RtR) movements are gaining momentum in many countries, including the UK, USA, and EU member states. While Universities are seen as important stakeholders to drive forward sustainable design practices, there is currently little work looking at training undergraduate design engineers in the principles of designing household products in support of RtR. In particular, the project‐based learning (PBL) pedagogy shows promise in engaging and training students with the skills and knowledge required to successfully design products for RtR. In this paper, a pilot‐study of teaching engineers is presented to design products compatible with RtR principles, alongside many technical skills, in a first‐year PBL course. The key outputs of this paper are the design of the module, which can be used to help inform first‐year engineering education, the high engagement of students, with 100% of respondents agreeing that they intend to try to implement sustainable design practices in future, and some of the innovative features that students implement in their projects.
Reduced Bone Regeneration in Rats With Type 2 Diabetes Mellitus as a Result of Impaired Stromal Cell and Osteoblast Function—A Computer Modeling Study
Authors: Jaber Mahdi , Hofbauer Lorenz C , Hofbauer Christine , Duda Georg N , Checa Sara 
Published: October 2023

ABSTRACTBone has the fascinating ability to self‐regenerate. However, under certain conditions, such as type 2 diabetes mellitus (T2DM), this ability is impaired. T2DM is a chronic metabolic disease known by the presence of elevated blood glucose levels that is associated with reduced bone regeneration capability, high fracture risk, and eventual non‐union risk after a fracture. Several mechanical and biological factors relevant to bone regeneration have been shown to be affected in a diabetic environment. However, whether impaired bone regeneration in T2DM can be explained due to mechanical or biological alterations remains unknown. To elucidate the relevance of either one, the aim of this study was to investigate the relative contribution of T2DM‐related alterations on either cellular activity or mechanical stimuli driving bone regeneration. A previously validated in silico computer modeling approach that was capable of explaining bone regeneration in uneventful conditions of healing was further developed to investigate bone regeneration in T2DM. Aspects analyzed included the presence of mesenchymal stromal cells (MSCs), cellular migration, proliferation, differentiation, apoptosis, and cellular mechanosensitivity. To further verify the computer model findings against in vivo data, an experimental setup was replicated, in which regeneration was compared in healthy and diabetic after a rat femur bone osteotomy stabilized with plate fixation. We found that mechanical alterations had little effect on the reduced bone regeneration in T2DM and that alterations in MSC proliferation, MSC migration, and osteoblast differentiation had the highest effect. In silico predictions of regenerated bone in T2DM matched qualitatively and quantitatively those from ex vivo μCT at 12 weeks post‐surgery when reduced cellular activities reported in previous in vitro and in vivo studies were included in the model. The presented findings here could have clinical implications in the treatment of bone fractures in patients with T2DM. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Effectiveness of leukapheresis on early survival in acute myeloid leukemia: An observational propensity score matching cohort study
Authors: Lee Howon , Han Jay Ho , Kim Jae Kwon , Yoo Jaeeun , Cho Hyung Suk , Yoon Jae‐Ho , Cho Byung Sik , Kim Hee‐Je , Lim Jihyang , Jekarl Dong Wook , Kim Yonggoo 
Published: October 2023

AbstractBackgroundThe association between leukapheresis (LK) as a treatment option for hyperleukocytosis (HL) in patients with acute myeloid leukemia (AML) remains controversial.MethodsData were extracted from the electronic medical record for 2801 patients with AML between April 2009 and December 2019. LK was performed when the leukocyte count was ≥100 × 109/L at the time initial bone marrow examination.ResultsA comparison between the patients with HL in the non‐LK (n = 1579) and LK (n = 208) groups revealed survival probabilities (%) of 93.2% and 90.4% (P = .130) for day 30 (D30), 85.4% and 84.2% (P = .196) for D60, and 83.6% and 80.8% (P = .258) for D90, respectively. After propensity score matching, a comparison between the patients with HL in the non‐LK (n = 192) and LK (n = 192) groups revealed survival probabilities (%) of 83.9% and 91.2% (P = .030) for D30, 75.0% and 84.9% (P = .015) for day 60 (D60), and 62.4% and 81.3% (P = .034) for day 90 (D90), respectively. After D150, the observed effect of LK appeared to be mitigated without a survival benefit.DiscussionLK was associated with improved early survival outcomes at D30, D60, and D90 among patients with AML exhibiting HL. Thus, it may be considered a treatment option for reducing cell mass in such patients.
Mutual induced‐fit controlled signal amplification of hydrogen‐bonded capsule formation
Authors: Kaur Sarvjeet , Sharma Bhanu , Lin E. S. , Lee M. M. , Kumar Gulshan , Chandrasekhar V. , Sun Shih‐Sheng , Singh Ashutosh S. 
Published: October 2023

AbstractMutual induced‐fit is well known process in biological system and playing crucial role in enzymatic catalysis, peptide‐bond synthesis, protein synthesis, etc…, proceeds by mutual interactions of two or more than two components. However, in an artificial system, to mimic such process is challenging, especially by purely organic components. In this report, we have shown importance of mutual induced‐fit in signal amplification of hydrogen‐bonded capsule formation. Two different types of highly flexible ligands (one N‐bridged and another triazine‐bridged) are used. N‐bridged tripodal ligand acting as clip over the adduct obtained from triazine‐bridged ligand, bringing the resultant adduct in the cone‐shape conformation. The resulting cone‐shape conformation undergo solvent polarity dependent hydrogen‐bonded capsule formation as a sole product. In absence of N‐bridged tripodal ligand, only 50% capsule formation is observed through 1H NMR at 100 mM concentration. However, in the presence of N‐bridged tripodal ligand, organic components undergo mutual interactions to opt the cone‐shape conformation and 100% capsule is formed (independent of concentration). The complete process is characterized by IR‐spectra, 1H and 13C NMR spectra, concentration dependent 1H NMR titration spectra, 1H‐1H COSY, 1H‐1H NOESY, DOSY NMR, high resolution ESI mass spectra, and also by energy‐minimized structure.
Leveraging machine learning to create user‐friendly models to mitigate appointment failure at dental school clinics
Authors: Cuevas‐Nunez Maria , Pan Allen , Sangalli Linda , Haering Harold J. , Mitchell John C. 
Published: October 2023

AbstractPurpose/ObjectivesThis study had a twofold outcome. The first aim was to develop an efficient, machine learning (ML) model using data from a dental school clinic (DSC) electronic health record (EHR). This model identified patients with a high likelihood of failing an appointment and provided a user‐friendly system with a rating score that would alert clinicians and administrators of patients at high risk of no‐show appointments. The second aim was to identify key factors with ML modeling that contributed to patient no‐show appointments.MethodsUsing de‐identified data from a DSC EHR, eight ML algorithms were evaluated: simple decision tree, bagging regressor classifier, random forest classifier, gradient boosted regression, AdaBoost regression, XGBoost regression, neural network, and logistic regression classifier. The performance of each model was assessed using a confusion matrix with different threshold level of probability; precision, recall and predicted accuracy on each threshold; receiver‐operating characteristic curve (ROC) and area under curve (AUC); as well as F1 score.ResultsThe ML models agreed on the threshold of probability score at 0.20–0.25 with Bagging classifier as the model that performed best with a F1 score of 0.41 and AUC of 0.76. Results showed a strong correlation between appointment failure and appointment confirmation, patient's age, number of visits before the appointment, total number of prior failed appointments, appointment lead time, as well as the patient's total number of medical alerts.ConclusionsAltogether, the implementation of this user‐friendly ML model can improve DSC workflow, benefiting dental students learning outcomes and optimizing personalized patient care.
The influence of licensure on ABGC certification examination outcomes
Authors: Wang Baijia , Conway Laura , Taylor Lynne , Valverde Kathleen 
Published: October 2023

AbstractThe genetic counseling field established ABGC certification and state licensure as professional standards for practice. All current state licensure laws require passing the ABGC certification examination, although states differ in their requirements regarding how soon after graduation the examination must be taken. Graduates in states without licensure can schedule the certification examination at their preference. This study explores the influence of licensure requirements on timing to take the examination and likelihood of passing the examination. Genetic counselors who graduated between 2017 and 2021 were invited to complete a 20‐question survey that included demographic information, first‐time pass rates, year of graduation and the month and year they took the certification examination. Usable responses were received from 246 genetic counselors who responded to the survey, a minimum response rate of 12.9%. Participants were largely female (92.7%), white (88.6%), and almost evenly divided between those whose first job was in a state with licensure (56.3%) and one without licensure (43.7%). Those who worked in states with licensure took the examination significantly sooner than those who worked in states without licensure (p = 0.028) and were 2.4 times more likely to fail the first attempt [95% CI = 1.08–5.49]). When asked about personal preference on timing of the examination, those who “would have waited if there were no licensure requirement” were almost 7 times more likely to fail the first attempt (RR = 6.81, 95% CI = 3.10–14.97). This study identified an association between state licensure requirements, genetic counselors' timing of taking the ABGC examination, and their examination performance. The data suggest that the element of choice is an important factor in pass rates. New graduates need to be aware of state‐specific licensure laws' impact on their ability to choose when to take the examination.
遅発性に低血圧とQT延長が生じたグアンファシン中毒の1例(Delayed hypotension and prolonged QT interval due to guanfacine poisoning)
Authors: 史也 井上 , 悠治 岡崎 , 稔久 市場 , 健一郎 柏 
Published: October 2023

要旨注意欠如多動性障害の17歳の女性が人間関係のトラブルを契機にグアンファシン3mg錠を50錠自ら過量服薬し来院した。来院時，低血圧はなかったが，傾眠，脈拍低下があり経過観察入院となった。入院翌日，歩行可能な状態となり自宅退院となったが，退院から2日後に自宅で失神し再度救急外来を受診した。脈拍低下，低血圧に加えて，心電図検査でQT延長があり再入院となった。過量服薬から7日後に徐脈およびQT延長は改善し自宅退院となった。グアンファシンは主に脳内のα2A受容体に作用し交感神経系の活動を低下させることで鎮静作用，脈拍低下・降圧作用をもたらす。グアンファシンの半減期は比較的長く，本例のように過量服薬時は傾眠，徐脈，低血圧が長期間遷延することがある。またグアンファシン内服初期は末梢血管平滑筋のα受容体を刺激することで高血圧を引き起こし，続いて中枢神経系への作用による低血圧が起こるという二峰性の血圧変動を来すことがあり，とくに低血圧に関しては遅発性に出現する可能性がある。本例において遅発性にQT延長を起こした原因は，3.4mg/kgと相当量の過量服薬をしていたことが一因と考えられる。グアファジンの過量服薬時は，遅発性に出現しうる低血圧とQT延長に留意した十分な期間の経過観察入院が必要だろう。
Breast‐to‐brain metastasis is exacerbated with chemotherapy through blood–cerebrospinal fluid barrier and induces Alzheimer's‐like pathology
Authors: Saatian B. , Deshpande K. , Herrera R. , Sedighi S. , Eisenbarth R. , Iyer M. , Das D. , Julian A. , Martirosian V. , Lowman A. , LaViolette P. , Remsik J. , Boire A. , Sankey E. , Fecci P. E. , Shiroishi M. S. , Chow F. , Hurth K. , Neman J. 
Published: October 2023

AbstractControl of breast‐to‐brain metastasis remains an urgent unmet clinical need. While chemotherapies are essential in reducing systemic tumor burden, they have been shown to promote non‐brain metastatic invasiveness and drug‐driven neurocognitive deficits through the formation of neurofibrillary tangles (NFT), independently. Now, in this study, we investigated the effect of chemotherapy on brain metastatic progression and promoting tumor‐mediated NFT. Results show chemotherapies increase brain‐barrier permeability and facilitate enhanced tumor infiltration, particularly through the blood–cerebrospinal fluid barrier (BCSFB). This is attributed to increased expression of matrix metalloproteinase 9 (MMP9) which, in turn, mediates loss of Claudin‐6 within the choroid plexus cells of the BCSFB. Importantly, increased MMP9 activity in the choroid epithelium following chemotherapy results in cleavage and release of Tau from breast cancer cells. This cleaved Tau forms tumor‐derived NFT that further destabilize the BCSFB. Our results underline for the first time the importance of the BCSFB as a vulnerable point of entry for brain‐seeking tumor cells post‐chemotherapy and indicate that tumor cells themselves contribute to Alzheimer's‐like tauopathy.
A dual‐path model of observers' responses to peer voice endorsement: The role of instrumental attribution
Authors: Ni Dan , Yang Mengxi , Chen Wansi 
Published: October 2023

SummaryPeer voice endorsement is widespread in the workplace. Drawing on social information processing theory and sociofunctional view, this paper proposes that observers' (both negative and positive) psychological and behavioral responses to peer voice endorsement depend on their instrumental attribution for peer voice. Specifically, when observers have a higher level of instrumental attribution, peer voice endorsement is more positively associated with status threat, in turn affecting observers' negative gossip. When observers have a lower level of instrumental attribution, peer voice endorsement is more positively associated with perceived peer competence, which in turn affects observers' role modeling proactive behavior. These results are largely supported by data from a multi‐wave field study and two experimental designs. The theoretical and practical implications of this study and future research directions are presented.
Tribological performance of polymeric friction modifiers under sliding rolling contact condition
Authors: Cyriac Febin , Tee Xin Yi , Chow Pui Shan 
Published: October 2023

AbstractThe tribological performance of two polymeric friction modifiers, one based on an ester‐based compound and another based on an ethoxylated fatty ester and an organic friction modifier, oleamide, was studied at 50, 90 and 140°C using a Mini Traction Machine equipped with optical interferometry and electrical contact resistance. The ability to form surface film is found to vary among the friction modifiers and with temperature and rubbing duration. Despite a thinner film being formed, polymeric friction modifier (PFMs) exhibited lower friction and wear than oleamide at all the studied temperatures. Further, the PFMs reduced boundary friction more effectively at higher temperature. In accordance with lower boundary friction, a smoother surface topography characterized by low wear was exhibited by PFM lubricated surfaces at higher temperatures. Scanning electron microscopy‐energy dispersive x‐ray analysis and time‐of‐flight secondary ion mass spectrometry provided insights on the tribofilm formation. The improvement in the tribological performance of PFMs is attributed to temperature‐induced conformation transition of adsorbed polymer chains on the surface. The results are corroborated by data obtained from dynamic light scattering and gel permeation chromatography.
Advances in the Study of Selenium‐Enriched Probiotics: From the Inorganic Se into Se Nanoparticles
Authors: Xiao Dan , Li Tong , Huang Xin , Zhu Kongdi , Li Zimeng , Dong Yulan , Wang Lianshun , Huang Jiaqiang 
Published: October 2023

AbstractSelenium (Se) is a momentous metallic element that plays an irreplaceable role in biochemical activities. Se deficiency remains a nutritional challenge across the world. Organic Se supplementation is the most effective treatment means for Se deficiency. Organic Se transformed from Se‐enriched probiotics show outstanding excellent properties in antibacteria, anti‐oxidation, anti‐inflammation, and immunoregulation. Studying the influencing factors for Se enrichment capacity and enrichment mechanisms of Se‐enriched probiotics is conducive to the exploit of more potent Se‐enriched probiotics. Se‐enriched probiotics transform inorganic Se into Se nanoparticles (SeNPs), which have been widely used in animal husbandry and biomedical field. In this paper, the novel development of Se‐enriched probiotics is reviewed, and the bioactivities of SeNPs are assessed, so as to display their potential application prospects. The excellent role of SeNPs in anti‐oxidation is summarized, and the mechanism by which SeNPs improve Se deficiency and boost animal health is explained.
Generation of frequency 16‐tupling millimeter wave without filtering based on cascaded Mach–Zehnder modulator
Authors: Wang Chong , Song Kun , Li Miaomiao , Yi Yi , Zhou Mengting , Wu Jiahui 
Published: October 2023

AbstractA scheme of generating millimeter‐wave signals with 16 times frequency using a cascaded Mach–Zehnder modulator (MZM) is proposed. Optical delay lines (ODLs) are used to place between cascaded MZMs, two MZMs work at the maximum transmission point. By controlling the modulation index of the MZM and the delay of the ODL, 0‐order, ‐order, and ‐order sidebands can be generated. The optical phase shifter and attenuator are adjusted to eliminate the 0‐order sideband, and the photodetector output generates a frequency 16‐tupling millimeter wave (MMW). In the simulation platform, a 160‐GHz MMW signal can be obtained by taking a 10‐GHz radio frequency signal as the driving signal of two MZMs. The optical sideband suppression ratio is 29.92 dB, and the radio frequency sideband suppression ratio is 24.89 dB. Further, the effect of system performance on optical devices under nonideal conditions is also discussed.
The factors that are associated with nurse immigration in lower‐ and middle‐income countries: An integrative review
Authors: Konlan Kennedy Diema , Lee Tae Wha , Damiran Dulamsuren 
Published: October 2023

AbstractAimThis study aims to synthesize the factors associated with nurse emigration from lower and middle‐income countries.DesignIntegrative review.MethodsAn in‐depth search of registries and five databases yielded 9466 records. Using the PRISMA guidelines, 11 were chosen after screening by two authors independently. The mixed methods appraisal tool (MMAT) was used to assess the risk of bias.ResultsThe destination countries were Europe and North America, with an inclination for nurse migration of 14.3%–85%. Emigration factors were poor salary, working conditions, poor quality healthcare infrastructure; outdated healthcare technologies, lack of employment opportunities, younger age, relationship status (single), living environment, social pressure, urban residence, work experience, insecurity, high crime rates, political corruption and foreign language skills.Public ContributionHealthcare authorities and nursing leaders must implement practical measures to minimize nurse emigration.
Preparation and characterizations of antibacterial and electroactive polymeric composites for wound healing applications
Authors: Unnikrishnan Gayathri , Joy Anjumol , Megha M. , Thomas Jibu , Haris M. , Kolanthai Elayaraja , Muthuswamy Senthilkumar 
Published: October 2023

AbstractPolymer nanocomposites have been utilized for wound healing applications. Compared to the conventional polymer composites, conducting polymer nanocomposites comprising a blend of biocompatible polymers with electroconductive and antibacterial nanofillers such as graphene‐based nanomaterials and metal/metal oxides, have attracted great attention in this arena due to enhanced physical, electrical and biological characteristics. Herein, polyvinyl alcohol (PVA)/chitosan (CS)/graphene oxide/zinc oxide electroconductive and antibacterial composite hydrogel films were fabricated by solution casting technique, for wound healing applications. The physicochemical and conductivity studies were carried out for all the polymer samples. The successful incorporation of the nanofillers and their even distribution into the PVA‐CS matrix was validated by the scanning electron microscopy‐EDAX, x‐ray diffractometer, Fourier‐transform infrared, and Raman analytical results. An enhancement in the surface roughness of the nanofiller incorporated composite film was elucidated by the topographical images obtained from AFM analysis. The composite with higher concentration of nanofillers exhibited a maximum conductivity of 0.35 10−4 Scm−1 compared to the other fabricated composites. A good antibacterial efficacy, minimal hemolytic activity as well as better thrombogenicity were portrayed by the composite films. Additionally, the nanocomposite films exhibited no cytotoxicity and excellent cell attachment and proliferation of RAW 264.7 cells. Therefore, based on the obtained results, it can be concluded that the composite with higher particle concentration, is an ideal candidate for futuristic wound dressing applications with electroconductivity, antimicrobial activity, hemostatic ability, and biocompatibility.Highlights
Fabrication of polyvinyl alcohol (PVA)/chitosan (CS)/GO‐ZnO hydrogel films by solvent‐casting
A maximum conductivity of 0.35 10−4 S/cm obtained for the composite film
Exhibited good antibacterial efficacy and minimal hemolytic activity
Better thrombogenicity and cytocompatibility portrayed by the composite
An ideal candidate for futuristic wound dressing applications