bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting the Emission of Greenhouse Gases in the UK using SARIMA Model
Authors: Lalwani Praneya , Shetty Ishita 
Published: October 2023

Abstract

Earth’s climate change is an important and urgent issue, and most researchers believe it is caused by greenhouse gas emissions. Carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) trap heat in the atmosphere, raising the temperature of our planet Human activity is the main source of greenhouse gases, including the burning of fossil fuels for energy, deforestation, and agriculture, all contribute to GHG emissions Earth’s temperature due to the accumulation of greenhouse gases (GHGs) in the atmosphere, and resulting in rising sea levels, frequency and intensity of heat waves, droughts, floods and in excess weather events. India has seen a sharp rise in greenhouse gas emissions in recent decades and was the third largest emitter of greenhouse gases in the world according to the Global Carbon Project In contrast, the United Kingdom has worked aggressively to reduce greenhouse gas emissions in recent years. The objective of this study, is to provide a composite time series approach, to estimate GHG emissions for various industries producing greenhouse gases contributing to climate change. We used estimated greenhouse gas emission data available for the UK, which occurred in 1990. We subsequently conducted an exploratory data analysis to study the contributions to the total GHG emissions observed suggests that in the energy supply, it accounts for about 40% of total emissions. Furthermore, the study shows that greenhouse gas emissions decreased significantly in the years following the implementation of policies to increase energy efficiency Compared to emissions in the case of the UK to those in India, we gained a better understanding of emission norms in India and identified areas that require improvement.
Replication protein-A, RPA, plays a pivotal role in the maintenance of recombination checkpoint in yeast meiosis
Authors: Shinohara Akira , Sampathkumar Arivarasan , Ito Masaru , Fujita Yurika 
Published: October 2023

Abstract
DNA double-strand breaks (DSBs) activate DNA damage responses (DDR) in both mitotic and meiotic cells. Meiotic DSBs induce homologous recombination monitored by a meiotic DDR called the recombination checkpoint for the pachytene exit in meiotic prophase I. In this study, we showed the essential role of a single-stranded DNA (ssDNA) binding protein, Replication protein-A (RPA), in the maintenance of the recombination checkpoint during S. cerevisiae meiosis. The depletion of an RPA subunit, Rfa1, in a recombination-defective dmc1 mutant, fully alleviates the pachytene arrest with the persistent unrepaired DSBs. RPA depletion downregulates a meiosis-specific CHK2 homolog, Mek1, which in turn activates Ndt80 transcriptional activator for pachytene exit. These support the idea that RPA is a sensor of ssDNAs for the activation of meiotic DDR. Rfa1 depletion also accelerates the prophase I delay induced by the zip1 mutant defective in both chromosome synapsis and the recombination, suggesting that the accumulation of ssDNAs rather than defective synapsis triggers prophase I delay in the zip1 mutant.
Biochemical and Histoarchitectural Evaluation of 4-Vinylcyclohexane Induced Ovarian Cancer Against Alpinia Purpurata (Vieill). K. Schum
Authors: CHITHAMONY ARUL RAJ , PALNIRAJAN ANUSOORIYA , RAJU MANIKANDAN VANI , CHANDRASEKARAN MEENAKSHI KANIYUR , AHALLIYA RATHI MUTHAIYAN , DUGGANABOYANA GURUKUMAR , KANNIAPPAN GOPALAKRISHNAN VELLIYUR 
Published: October 2023

Abstract

Objective Alpinia purpurata is being studied for its potential to treat various conditions, including diabetes, arthritis, and tuberculosis. This research explores the impact of Alpinia purpurata (Vieill). K. Schum on ovarian cancer induced by 4-vinyl cyclohexane in Wistar albino rats.Materials and methods Five sets of 100-120g Wistar albino rats were assembled. Group 1 was the control group. Group 2 received intraperitoneal 4-vinyl cyclohexane (80 mg/kg) for one month. For two months, Group 3 was given A. purpurata leaf extract (200 mg/kg) orally. Cisplatin (5 mg/kg) intraperitoneal twice per week for two months was given to Group 4 as a standard drug. For two months, Group 5 acquired daily oral A. purpurata leaf extract (200 mg/kg). The rats were euthanized after the experiment under light chloroform anesthesia. Ovary and liver samples were obtained for lipid peroxidation, anti-oxidants, membrane-bound enzymes, tumor indicators, and histological investigation.Results Over a 60-day period, rats were given an ethyl acetate extract of A. purpurata at a dose of 200 mg/kg, which lead to in a substantial (p < 0.05) increase in body protein content, as well as enzyme levels. Furthermore, the use of the ethyl acetate extract significantly (p < 0.05) recovered the altered lipid peroxidation activities in the ovarian tissues of both control and experimental rats to near-normal levels. These data imply that the extract has the capacity to quench free radicals, indicating possible anticancer effects.Conclusion The results suggested that, the ethyl acetate extract of A. purpurata exhibited significant antitumor activity on ovarian cancer bearing rats.
Globally nitrogen deposition decreased net carbon sequestration in terrestrial ecosystems by increasing plant-derived carbon decomposition rather than soil priming effects: A meta-analysis
Authors: Dong Hongxin , Lu Jiayu , Liu Minghui , Tao Lei , Lin Junjie , Li Lu-Jun 
Published: October 2023

Abstract
Aims Plant carbon (C) input and soil priming effects (PEs) together determine the net C sequestration of terrestrial ecosystems. These processes are recognized to be largely influenced by nitrogen (N) availability, the global patterns of N deposition effects on soil net C sequestration and the controlling factors for such effects remain unclear.
Methods In this study, we conducted a meta-analysis of 2205 observations from 56 studies worldwide to explore the effect of mineral N addition on net C sequestration and the associated drivers.
Results The meta-analysis found that although mineral N addition reduced soil PEs, it still decreased soil net C sequestration by increasing plant-derived C decomposition. The decrease of net C sequestration was much greater by urea addition than by ammoniacal and nitrate N addition. In addition, mineral N addition only decreased net C sequestration under pyrolytic C and residue C substrate forms. The higher soil organic C (SOC) and total N (TN) content increased net C sequestration by decreasing soil PEs rather than plant-derived C decomposition. Higher soil clay content reduced net C sequestration by increasing plant-derived C decomposition rather than soil PE. Higher incubation temperature reduced net C sequestration by increasing SOC and plant-derived C decomposition. Longer incubation time increased net C sequestration by reducing the decomposition of SOC and plant-derived C decomposition.
Conclusions These results are beneficial for understanding the response of soil net C sequestration to global N deposition, and could improve the prediction of terrestrial ecosystems C balance under global climate changes.
Effects of aerobic exercise on demyelination and brain morphology in the cuprizone rat model of multiple sclerosis
Authors: abbasi maryam , Arghavanfar Hadis , Hajinasab Sepideh , nooraei aref 
Published: October 2023

Abstract
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that led to brain atrophy. The purpose of this study was to investigate the effects of pre-and post-conditioning with exercise on demyelination and brain morphology. Thirty male rats were randomly divided into five groups (n = 6 per group), consisting of a healthy control group (Control), an MS group, and three exercise groups: the group that performed the exercise protocol (running on a treadmill 5 days/week for 6 weeks) before the MS induction (EX + MS), the group that performed the exercise protocol during the MS induction (MS + EX), and the group that performed the exercise protocol before and during the MS induction (EX + MS + EX). The expression of Myelin basic protein (MBP), and demyelination in the corpus callosum and the volume, weight, length, width, and height of the brain were measured. The EX + MS + EX showed a significant increase in the expression of MBP compared to other MS groups (**p < 0.01) as well as a significant decrease in the area of demyelination of the corpus callosum compared to MS and MS + EX groups (**p < 0.01). However, there were no significant differences between the MS group and exercised groups for brain morphology. The exercise showed neuroprotective effects, as evidenced by decreased areas of demyelination and improved MBP expression.
Considering Peer Support Sustainability: Survey of geographic differences in roles, skills, job satisfaction, and financial well-being
Authors: Voss Maren , Barrett Tyson , Lapidos Adrienne , Werner Pam , Bennett Pamela , Campbell Amy , Komen Amelia Van 
Published: October 2023

Abstract
Background
The peer support workforce has become an established aspect of behavioral health care, with endorsement since 1999 as Medicaid reimbursable and with steady uptake of credentialing by 49 states and the District of Columbia. Yet sustainability issues due to wage and entry-level stagnation lacking advancement paths is a concern for the Certified Peer Support Specialists (CPSSs) workforce.
Methods
This analysis compared cross-regional survey data of employed CPPSs in Utah (U) to a prior Michigan (M) sample. The core areas of investigation were 1) health and well-being, 2) professional settings, activities, and opportunities, and 3) perceptions regarding professional practice.
Results
Over 85% of Utah peers expressed satisfaction with work hours, physical safety at work, and supportiveness of supervisors, similar to 75% Michigan sample satisfaction. Job security satisfaction differed at 87% in Utah and 67% in Michigan, with a higher average wage in Utah. Less satisfaction was reported for promotion opportunities (U-57%, M-41%) and coworker awareness of peer roles (U-34%, M-42%).
Conclusions
Results indicate similar workforce conditions across regions, but with higher pay and slightly higher satisfaction ratings in the Utah sample of mixed recovery and mental health peers. Both areas demonstrate a need for training non-peer staff on CPSS job roles, indicating a lack of clarity regarding the professional contributions of peers. Practical administrative steps to support sustainability include stigma-reducing workplace policies, trainings, career laddering with increased responsibility, sustainable wage and benefit packages consistent with career laddering, and reinforcing consensus around defined roles and competencies of peer support.
Agreement between face‑to‑face assessment and tele‑assessment of performance-based tests in older adults
Authors: Ozsoy Gulsah , AKSOY Kevser 
Published: October 2023

Abstract
Purpose
This study aimed to assess Timed-Up and Go (TUG), Five Times Sit-to-Stand Test (5xSST), and 4-Meter Walk Test (4MWT) intra- and inter-rater reliability between face to face and tele-assessment tools in older adults.
Methods
A total of 54 older adults (aged ≥ 65 years) were included in the study. The demographic and clinical characteristics of the participants were documented. Measurements (TUG, 5xSST, and 4MWT) were carried out face-to-face and tele-assessment. The intraclass correlation coefficients (ICCs), and Bland-Altman plots was used determine intra- and inter-rater reliability.
Results
Inter-rater reliability between face-to-face and tele-assessment was as following: excellent for TUG (ICC = 0.931) and 5STS (ICC = 0.908), and good for 4MWT (ICC = 0.803). Additionally, intra-rater reliability between the two tele-assessments was excellent for all tests. The ICC values for TUG, 5STS, and 4MWT were 0.973, 0.948, and 0.934, respectively.
Conclusion
To conclude, the TUG, 5xSST, and 4MWT seem to be reliable tools of tele-assessment in older adults. These practical assessment tools can be used in home settings for older adults as tele-health interventions.
A novel super-convergent numerical method for solving nonlinear Volterra integral equations based on B-splines
Authors: Ghasemi Mohammad , Goligerdian Arash , Moradi Sina 
Published: October 2023

Abstract

‎We introduce and thoroughly examine a novel approach grounded in B-spline techniques to address the solution of second-kind nonlinear Volterra integral equations‎. ‎Our method revolves around the application of B-spline interpolation‎, ‎incorporating innovative end conditions‎, ‎and delving into the associated existence and error estimation aspects‎. ‎Notably‎, ‎we develop this technique separately for even and odd-degree splines‎, ‎leading to super-convergent approximations‎, ‎particularly significant when employing even-degree splines‎. ‎This paper extends its commitment to a comprehensive analysis‎, ‎delving deeply into the method's convergence characteristics and providing insightful error bounds‎. ‎To empirically validate our approach‎, ‎we present a series of numerical experiments‎. ‎These experiments underscore the method's efficacy and practicality‎, ‎showcasing numerical approximations that closely align with the anticipated theoretical outcomes‎. ‎Our proposed method thus emerges as a promising and robust tool for addressing the challenging realm of nonlinear Volterra integral equations‎, ‎bridging the gap between theoretical expectations and practical applications‎.
2010 Mathematics Subject Classifications: 45Dxx; 65R20; 41A15.
Coupled scRNA-Seq and Bulk-seq Reveal the Role of HMMR in Hepatocellular Carcinoma
Authors: Su Zhixiong , You Lijie , He Yufang , Chen Jingbo , Zhang Guifeng , Liu Zhenhua 
Published: October 2023

Abstract
Background
Hyaluronan-Mediated Motility Receptor (HMMR) has been demonstrated to be overexpressed in multiple carcinomas and to influence the development and treatment of several cancers. However, its role in hepatocellular carcinoma (HCC) remains unclear.
Methods
The “limma” package in R was used to perform differential expression analysis. The “GSVA” package in R was used to assess the activity of signaling pathways, and inferCNV was used to infer copy number variation (CNV) for each hepatocyte. “CellChat” was used to analyze intercellular communication networks. Recursive partitioning analysis (RPA) was to re-stage HCC patients. The “pRRophetic” package was used to evaluate the IC50 values of some drugs. Additionally, qRT-PCR was performed to confirm HMMR expression in an HCC tissue microarray. Flow cytometry (FCM) and cloning, Edu assay, and wound healing assays were used to explore the capacity of HMMR to regulate HCC tumor.
Results
HMMR was over expressed in HCC tissue (compared to normal tissue), which was proved by multiple cohort studies and qRT-PCR. In addition, HMMR had excellent diagnostic performance. HMMR knockdown could inhibit the proliferation and migration of HCC cell lines. Moreover, high HMMR expression was associated with “G2M checkpoint” and “E2F targets” in bulk RNA and scRNA-seq, and FCM confirmed that HMMR could regulate the cell cycle. In addition, HMMR was involved in the regulation of tumor immune microenvironment via immune cell infiltration and intercellular interactions. Furthermore, HMMR was positively correlated with genomic heterogeneity and patients with high HMMR expression may benefit better from immunotherapy. Moreover, HMMR was associated with poor prognosis in HCC patients and the re-staging by RPA had a good prognosis prediction value and could guide chemotherapy and targeted therapy.
Conclusion
According to the results of the present study, HMMR could play a role in the diagnosis, prognosis and treatments of patients with HCC based on bulk RNA-seq and scRAN-seq analyses, and is a promising molecular marker for HCC.
Treatment Outcomes in Patients with Acute Thromboembolic Occlusion of the Superior Mesenteric Artery
Authors: Li Wenrui , Liu Mingyuan , Jin Lei , Feng Hai , Chen Xueming , Zhang Zhiwen 
Published: October 2023

Abstract
Purpose: The goals of this study were to investigate the treatment outcomes of acute thromboembolic occlusion of the superior mesenteric artery (ATOS) and identify prognostic factors after treatment.
Methods: The clinical data of 62 patients with ATOS between 2013 and 2021 were retrospectively reviewed.
Results: Sixty-two consecutive patients were identified with ATOS. The medianpatient age was 69 years (interquartile range 58–79 years). Endovascular therapy was initiated in 21 patients, and 4 patients received conservative treatment. Open surgery was performed first in the remaining 37 patients. The technical success rates of the endovascular first group and open surgery group were 90.5% and 97.3%, respectively. One patient in the conservative treatment group had progression of ischemia to extensive bowel necrosis. There was no difference in 30-day mortality between these groups. Predictors of 30-day mortality included a preoperative neutrophil count>12* 103/dL (OR 11.15, p=0.014).
Conclusions: Endovascular treatment or conservative treatment may be adopted in selected patients who do not exhibit signs and symptoms of bowel necrosis, and close monitoring for bowel necrosis is important. The increase in preoperative neutrophil count was a poor prognostic factor.
IBMESR: Towards Next-Generation Big Data Security with An Integrated Blockchain Model for Efficient, Scalable, and Robust Operations
Authors: Tota Madhavi , Karmore Swapnili 
Published: October 2023

Abstract

As the utilization of big data environments becomes increasingly widespread, the demand for robust and efficient security mechanisms within this context becomes paramount, especially in real-time scenarios. Ensuring data integrity, trust, and availability in multi-cloud environments is of utmost importance. Existing solutions often fall short in these aspects, resulting in issues such as latency, energy inefficiency, and vulnerability to access attacks, among other drawbacks. Traditional security models designed for big data environments tend to rely on ineffective proof mechanisms and static encryption methods. These conventional approaches lead to increased data processing delays, heightened energy consumption, and reduced communication throughput. Furthermore, these existing models have demonstrated limited capabilities in accurately identifying unauthorized access attempts, thereby escalating security risks. This paper introduces an innovative security framework tailored for big data environments, which leverages a suite of cutting-edge technologies to address the limitations of current models. The proposed architecture integrates several key components, including a Proof of Spatial & Temporal Trust-based Blockchain for secure storage operations, Grey Wolf Optimization (GWO) for efficient blockchain sharding, Fully Homomorphic Encryption (FHE) for safeguarding data across various data nodes, Physical Unclonable Functions (PuFs) for resilient inter-data node communications, and Fuzzy Rule-Based Access Control to enhance overall security. Our research results demonstrate that this proposed model significantly mitigates the inefficiencies and vulnerabilities that currently plague big data security systems. Specifically, it achieves an 8.3% reduction in data processing delays, a 4.5% reduction in energy consumption, a 2.9% improvement in communication throughput, an 8.5% enhancement in the accuracy of detecting access attacks, and a 3.5% increase in access speed levels. This innovative security framework tailored for big data environments offers a comprehensive and effective approach to overcome the limitations of existing solutions. It represents a significant advancement in the field of big data security, contributing significantly to ongoing efforts aimed at creating more secure, efficient, and resilient big data ecosystems.
Liver, Metabolic and Atherosclerotic Risks of Patients with Cryptogenic Steatotic Liver Disease
Authors: Wang Shao-Wen , Hsieh Tsung-Han , Cheng Yu-Ming , Wang Chia-Chi , Kao Jia-Horng 
Published: October 2023

Abstract
Background & Aims:
In 2023, a new nomenclature of "metabolic associated steatotic liver disease" (MASLD) has emerged by incorporating cardiometabolic risk factors to redefine "non-alcoholic fatty liver disease" (NAFLD). Among steatotic liver disease (SLD), a subgroup of cryptogenic SLD denotes hepatic steatosis without metabolic dysfunction. Its clinical characteristics remain unclear. .
Approach:
We analyzed participants with liver ultrasound data from the Taiwan Bio-Bank cohort, excluding those with positive HBsAg, positive anti-HCV, or “frequent drinker”. MASLD involves hepatic steatosis and any of five cardiometabolic risk factors, whereas cryptogenic SLD features hepatic steatosis without these risk factors. Liver fibrosis severity was assessed by using NAFLD fibrosis score (NFS), while atherosclerosis was determined by carotid plaques on duplex ultrasound.
Results
Among 17,595 subjects (mean age 55.59 ± 10.4; 31.8% males), 7538 participants (42.8%) had SLD, comprising 96.5% of MASLD and 3.5% of cryptogenic SLD. Cryptogenic SLD patients are younger and had a lower percentage of male than those with MASLD. After propensity score matching for age and sex, patients with cryptogenic SLD exhibited milder glucose and lipid profiles, fewer carotid plaques, lower liver steatosis, inflammation, and fibrosis markers than those with MASLD.
Conclusions
In this large population-based study, cryptogenic SLD, the excluded group, occupy only 3.5% in NAFLD patients. It has lower liver, metabolic, and atherosclerotic risks than MASLD, supporting its exclusion from NAFLD and justifying the rationale for the new disease name and diagnostic criteria of MASLD.
Carbon-Enhanced Aluminum-Based Adsorbent for Highly Efficient Removal of Fluoride Contamination from Water
Authors: Tong Lin , Miao Ying , Li Shushu , Bao Ning , Zhou Qingwen , Yang Yuhuan , Ye Changqing 
Published: October 2023

Abstract
Excessive fluoride presence in water poses significant environmental and public health risks, necessitating the development of effective remediation techniques. Conventional aluminum-based adsorbents face inherent limitations such as limited pH range and low adsorption capacity. To overcome these challenges, we present a facile solvent-thermal method for synthesizing a carbon-doped aluminum-based adsorbent (CDAA). Extensive characterization of CDAA reveals remarkable features including substantial carbon-containing groups, unsaturated aluminum sites, and a high point of zero charge (pHpzc). CDAA demonstrates superior efficiency and selectivity in removing fluoride contaminants, surpassing other adsorbents. It exhibits exceptional adaptability across a broad pH spectrum from 3 to 12, with a maximum adsorption capacity of 637.4 mg/g, more than 110 times higher than alumina. The applicability of the Langmuir isotherm and pseudo-second-order models effectively supports these findings. Notably, CDAA exhibits rapid kinetics, achieving near-equilibrium within just 5 minutes. Detailed analyses employing FTIR and XPS provide profound insights into the underlying mechanisms governing the adsorption process, which is facilitated by the active involvement of carbon-containing functional groups. The exceptional attributes of CDAA establish its immense potential as a transformative solution for the pressing challenge of fluoride removal from water sources.