bluuebunny/crossref_metadata_2025_split huggingface dataset:
99m TC HM‐PAO SPECT in Pediatric Migraine
Authors: Battistella P.A. , Ruffilli R. , Pozza F. Dalla , Pitassi I. , Casara G.L. , Boniver C. , Suppiej A. , Bendagli B. , Condini A. 
Published: May 2005

SYNOPSIS 99m TC HM‐PAO SPECT brain imaging was performed during the headache‐free period in 19 young migraineurs, affected by common migraine (CM, 10 cases), classic migraine (CLM, 6 cases) and hemiplegic migraine (HM, 3 cases). SPECT findings were negative in all 10 patients with CM, in 3 cases of CLM and in 2 cases of HM. Positive findings in the remaining 4 patients (3 cases of CLM and I of HM) showed a decreased tracer distribution in the temporo‐occipital regions (2 cases) and parietal regions (2 cases): the two with decreased temporo‐occipital perfusion reported prodromal symptoms exclusively contralateral to the areas of hypoperfusion. An impaired regional cerebral vascular autoregulation may exist even during headache‐free intervals in patients suffering from classic and hemiplegic migraine.
Cerebral Vein Thrombosis Shown by MRI
Authors: Salvati Carl A. 
Published: May 2005

SYNOPSISA 46 year old man with a short history of left facial pain and numbness, and subsequently headaches, had a normal physical examination and a normal CT scan of head. Lumber puncture yielded normal CSF under increased pressure. MRI showed thrombosis of the superior sagittal sinus, subsequently confirmed by angiography. MRI is a sensitive test for detecting intracranial venous thrombosis, and may be the investigation of choice when this disorder is suspected.
Relaxation Training in School Classes Does Not Reduce Headache Complaints
Authors: Passchier J. , van den Bree M.B.M. , Emmen H.H. , Osterhaus S.O.L. , Orlebeke J.F. , Verhage F. 
Published: May 2005

SYNOPSISThe effect of teacher‐presented Progressive Relaxation Training (PRT) on headaches, fear of failure and school problems was studied in school students. During ten physical education lessons, students received either PITT (n = 110) or placebo training (n=92). The effect of the training was investigated in students who indicated the presence of headaches in a pre‐training diary. No significant differences were found between both training groups regarding headache frequency, duration and intensity and the psychological variables. On the basis of these and previous findings, it is recommended to present PRT to fairly small groups of self‐selected subjects instead of complete classes.
Pharmacokinetics of Tiaprofenic Acid After Oral Administration in Fasting Patients During and Between Migraine Attacks
Authors: Pini Luigi‐Alberto , Bertolotti Marco , Bergonzini Giuliano , Casalgrandi Leonello , Giroldi Liviana , Sternieri Emilio 
Published: May 2005

SYNOPSISThis study examined the pharmacokinetics of 300 mg of tiaprofenic acid, a NSAID belonging to the 2‐arylpropionic class, as a single oral dose, in 10 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. Drug absorption appeared to be the same during and out of migraine attacks (absorption half life: during attack, 0.249±0.122 hr; out of attack, 0.249 ± 0.105 hr; maximum plasma concentration: during attack, 37.8±9.8 ug/ml; out of attack, 40.1 ± 13.2 ug/ml). The other pharmacokinetic parameters evaluated were not affected by headache attacks as well. We conclude that tiaprofenic acid absorption and metabolism are not affected by migraine attacks. Also, our data suggest that tiaprofenic acid might be useful in the treatment of migraine.
Noninvasive Trigeminal Evoked Potentials: Normative Data and Application to Neuralgia Patients
Authors: Dalessio Donald J. , Mclsaac Heather , Aung Maung , Polich John 
Published: May 2005

SYNOPSISA mild electric shock applied to the lower lip was used to elicit reliable evoked potentials from the trigeminal nerve in 20 normal young adults. The wave forms were morphologically similar to those observed with invasive procedures. No substantial differences for either the right or left side of stimulation, recording electrode, or subject sex were obtained for any of the individual potential amplitudes or latencies. The same procedures were applied to 10 patients who had been treated with retrogasserian glycerol injections for trigeminal neuralgia. Trigeminal evoked potentials were elicited in all patients, although the quality of the individual wave forms was more variable than that observed for the normal subjects. Comparison of the treated with the unaffected face side in the patients demonstrated significantly smaller N2‐P2 amplitudes and longer N2 latencies for the affected face side. The results suggest that these procedures produce reliable evoked potential measures of trigeminal nerve function noninvasively which can provide an objective index of treatment efficacy.
Common Headaches: Type, Duration, Frequency and Implications
Authors: Blau J. N. 
Published: May 2005

SYNOPSISQuestionnaires completed by 327 preclinical medical and dental students showed that 97.9% had experienced headaches, most frequently attributed to insufficient sleep (38.8%), mental stress (38.8%), alcohol (38.5%), excess heat (36.7%), reading (31.5%), excess noise (29.9%) or light (27.7%), and sleeping too long (23.5%). The frequency and duration of these and other headaches are listed. 8% of the headache group had consulted a doctor. Only 2.1% of all students had never experienced a headache.Two hypotheses are examined: (1) can headaches be normal?‐delineated by their disappearing soon after the noxious stimulus has ceased; (2) can pain in the head, as elsewhere in the body, act as a warning and therefore have protective, even survival value?
Naproxen Sodium in Menstrual Migraine Prophylaxis: A Double‐Blind Placebo Controlled Study
Authors: Sances G. , Martignoni E. , Fioroni L. , Blandini F. , Facchinetti F. , Nappi G. 
Published: May 2005

SYNOPSISIn this study, the efficacy of Naproxen sodium (Nxs) in the prophylaxis of Menstrual Migraine (MM) was tested, versus Placebo (PL). Forty women suffering from MM were admitted to a double‐blind treatment protocol with Nxs 550 mg twice each day by mouth or Placebo (PL), for 3 months; in the next 3 months all the women were treated with the active drug in an open study. The headache intensity and duration, as well as the number of days of headache and the analgesic consumption, were significantly reduced with Nxs compared to PL.The efficacy of Nxs, shown also in improving premenstrual pain, and its good tolerability, support the use of this drug in the prophylactic therapy of MM.
A Comparative Study of Naproxen Sodium, Pizotyline and Placebo in Migraine Prophylaxis
Authors: Bellavance André J. , Meloche Jacques R 
Published: May 2005

SYNOPSIS318 patients satisfying the Ad Hoc Committee's criteria for common or classical migraine were entered into an 8 week single‐blind placebo recording phase to establish, by diary cards, the frequency and severity of their attacks. 176 patients completed this and had records indicating 4–8 episodes in the 8 week period, with sufficient severity to reduce activity and/or work; these patients wore randomized by a predetermined code, into three double‐blinded groups: naproxen sodium 550 mg bid (60 patients), pizotyline 0.5 mg tid (59 patients), or placebo (57 patients). The patients wore followed at monthly intervals for 12 weeks, with 25 dropping out (3 on naproxen sodium, and 2 each on pizotyline and placebo because of “side effects;” the remaining 18 because of noncompliance or reasons unrelated to therapy). Approximately 25% of patients in each of the 3 groups complained of side effects.Statistical analysis showed that both naproxen sodium and pizotyline were better than placebo, and of overall equivalent (i.e. equal) efficacy in the prophylaxis of migraine. In some respects, naproxen sodium was slightly more effective than pizotyline in the first month of treatment.
Cervicogenic Headache: Diagnostic Criteria
Authors: Sjaastad O. , Fredriksen T.A. , Pfaffenrath V. 
Published: May 2005

SYNOPSISCriteria for the diagnosis of cervicogenic headache are proposed, which include unilateral head pain, symptoms and signs of neck involvement, non‐clustering episodic moderate pain originating in the neck then spreading to the head, and response to root or nerve blockade; plus rarer and non‐obligatory features such as autonomic disturbances, dizziness, phonophotophobia, monocular visual blurring, and difficulty swallowing.
Angiographic Changes Suggestive of Vasospasm in Migraine Complicated by Stroke
Authors: Spierings Egilius L.H. 
Published: May 2005

SYNOPSISA 30‐year‐old woman with a history of common migraine developed a permanent left homonymous hemianopia during a typical headache. CT scan demonstrated a right posterior cerebral infraction and angiography showed irregular narrowing of the ipsilateral posterior cerebral artery, suggestive of vasospasm. In the case no risk factors for atherosclerotic stroke were present except for smoking, and no other causes of stroke could be found.
The Headache‐Specific Locus of Control Scale: Adaptation to Recurrent Headaches
Authors: Martin Nancy J. , Holroyd Kenneth A. , Penzien Donald B. 
Published: May 2005

SYNOPSISThis paper describes the development, psychometric properties, and construct and incremental validity of a Headache‐Specific Locus of Control Scale (HSLC). The HSLC is a 33 item scale designed specifically for recurrent headache sufferers. It assesses the individual's perceptions that headache problems and headache relief are determined primarily by: the individual's behavior (Internal factors), Health Care Professionals, or Chance factors. The psychometric properties of the HSLC were satisfactory. Among our findings were that: (1) the belief that headache problems and relief are determined by chance factors was associated with higher levels of depression, physical complaints, reliance on maladaptive pain coping strategies ( p < .001), and greater headache‐related disability ( p <.01); (2) the belief that headache problems and relief are influenced primarily by the ministrations of health care professionals was associated with higher levels of medication use ( p <.01) and preference for medical treatment ( p <.001); and (3) the belief that headache problems are determined by the individual's responses and behaviors was associated with a preference for self‐regulation treatment ( p <.01). These findings suggest adaptation to headache problems is influenced not only by the frequency and severity of the headache episodes, but by locus of control beliefs. The assessment of locus of control beliefs may provide useful information not typically obtained from standard medical evaluations.
Treatment of Status Migrainosus: The American Experience
Authors: Raskin Nell H. 
Published: May 2005

SYNOPSISDependence upon a variety of drugs ‐ ergotamine, analgesics, benzodiazepines, corticosteroids ‐is a major reason for patients to enter an intractable phase of their migrainous disorders. Repeated dosing of dihydroergotamine has proven to be remarkably effective in stabilizing the mechanism of migraine, allowing these patients to make the transition to a more reasonable as well as more specific form of therapy.
Sumatriptan in Acute Migraine: Pharmacology and Review of World Experience
Authors: Peroutka Stephen J. 
Published: May 2005

SYNOPSISThe introduction of sumatriptan, a novel abortive anti‐migraine agent, has generated a significant amount of preclinical and clinical interest during the past few years. At the scientific level, sumatriptan is unique in terms of its selective pharmacological properties. The effects of sumatriptan in various experimental paradigms have led to new insights into the pathophysiology of migraine. At the clinical level, sumatriptan appears to be an effective abortive anti‐migraine agent with minimal side effects. Its ability to decrease, rather than exacerbate, the nausea and vomiting of migraine appears to be an important advance in the treatment of migraine.
Psychophysiological Parameters of Migraine and Muscle‐Contraction Headaches
Authors: Lichstein Kenneth L. , Fischer Suzanne M. , Eakin Terry L. , Amberson Janis I. , Bertorini Tulio , Hoon Peter W. 
Published: May 2005

SYNOPSISPrevious headache studies have been unable to verify the presumed presence of headache. Attempting to correct this design fault, the present study assessed four psychophysiological measures (frontalis EMG, temporal BVP, temporal and finger skin temperature) and salient subjective measures in 13 migraineurs, eight muscle‐contraction headache sufferers, and 13 age‐matched normals. All subjects submitted to two 30‐minute sessions of quiet monitoring, and for the headache subjects, one of the sessions was headache active. A bogus, but convincing preliminary ”assessmentldquo; revealed insufficient headache activity in the headache active session, forcing subjects to reschedule that session in the future when a strong headache was present. A parallel manipulation was employed with the normal subjects. A MANOVA failed to discriminate within‐ or between‐group differences on the psychophysiological measures. Self‐reported pain was uncorrelated with the psychophysiological indices. These results cast further doubt on the validity of the psychophysiological measures employed in this study, the same ones routinely endorsed by headache researchers and therapists. We discuss problems of recruitment, compliance, and attrition in basic headache research.
The Role of Family Structure, Functioning, and Pain Modeling in Headache
Authors: Ehde Dawn M. , Holm Jeffrey E. , Metzger Dana L. 
Published: May 2005

SYNOPSISIn an initial attempt to examine relationships between family functioning and chronic headache disorders, the present study examined: a) family structure characteristics, b) family functioning, and c) family pain modeling. Subjects completed an assessment battery consisting of several measures of family functioning. Analyses showed that migraine sufferers (N = 42) as compared to headache‐free controls (N=59) were more likely to describe their families as emphasizing clear organization, structure, rules, and overall control, but less likely to encourage emotional expression. No differences were found between tension headache subjects (N = 43) and headache‐free controls. While only an initial exploration of the importance of family characteristics in chronic headache, these results suggest that there are important differences in headache subjects' (particularly migraine) reports of family environment and functioning.
Bioelectrical Impedance Assay (BIA) of Total Body Composition in Alcohol‐Induced Migraine Patients. Preliminary Report.
Authors: Martelletti P. , Andreoli A. , Bernoni R.M. , Sabato F. Di , Del Bolgia F , Baldi A. , Sasso G.F. , Bare R , De Lorenzo A. , Giacovazzo M. 
Published: May 2005

SYNOPSIS“Whole body composition” was investigated in 30 people subject to alcohol‐induced migraine. The control group was 30 people matched for age, sex, height and weight, who were not subject to migraine and who consumed moderate amounts of alcohol. The following were evaluated: anthropometric data, alcohol intake in grams per day, total body water, fat‐free mass, fat mass, and body mass index (kg/m 2 ). Two methods of measurement were used: skin fold thickness evaluation, and bioelectric impedance assay (BIA). BIA is a non‐invasive method based on the principle that lean tissues conduct a low frequency alternating current of electricity better than do fatty tissues.Body mass index was increased in the alcohol‐induced migraine patients (p<0.04), as was fat mass, (p<0.03) as evaluated by skin fold measurements. Bioelectric impedance assay demonstrated a slight total body water increase in alcohol‐induced migraine patients (p<0.07).Possibly, if this total body water increase was reflected at the neuronal level, the bioelectric properties of the migrainous brain may be altered, thus creating a hypothetical link with the phenomenon of spreading depression.
Recurrent Prolonged Coma Due to Basilar Artery Migraine. A Case Report.
Authors: Frequin S.T.F.M. , Linssen W.H.J.P. , Pasman J.W. , Hommes O.R. , Merx H.L. 
Published: May 2005

SYNOPSISA 25 year old patient presented with recurrent prolonged episodes of life‐threatening coma varying from 3 to 10 days. The clinical recovery was slow. The history and technical examinations led to the diagnosis of basilar artery migraine (BAM).The etiology of the coma episodes is thought to be related to ischemic dysfunction of the rostral part of the brainstem due to severe spasm of the basilar artery demonstrated by arteriography.Exceptional are the recurrent prolonged coma episodes of sudden onset, the severe spasm of the basilar artery, and the suppression‐burst and FIRDA pattern on the EEG examinations during the coma episodes.
On Pain Mechanisms in Cluster Headache
Authors: Hardebo Jan Erik 
Published: May 2005

SYNOPSISVarious possible pathophysiological mechanisms to explain the pain in cluster headache are reviewed. Several locations for the initiation of pain along the primary afferent pathways in cranial nerves are discussed, together with the local mechanisms that might be responsible. These include neurogenic inflammation of large cranial vessels, irritation of vascular pain fibres by compression of dilated vessels in bony canals, and irritative foci in or around cranial sensory ganglia. In particular, recent neuroanatomical and pharmacological findings on nociceptive innervation of the intracranial segment of the internal carotid artery are commented upon. The possibilities for referred pain to explain the location of pain is illustrated. Evidence for involvement of central pain modulatory systems in the pain production is discussed. Finally a synthesis is made of the probable peripheral and central pain mechanisms in the disease.
MSG and Hydrolyzed Vegetable Protein Induced Headache: Review and Case Studies
Authors: Scopp Alfred L. 
Published: May 2005

SYNOPSISMonosodium glutamate (MSG), an established headache trigger, has become far more prevalent in canned, packaged and prepared foods over the past decade. The presence of MSG in food may be difficult to detect since the terms “natural flavor,”“flavoring,” or “hydrolyzed vegetable protein (HVP),” all may appear on food labels to refer to MSG, according to current FDA food labeling code. HVP typically contains 10–30% MSG.Case studies are presented in which the elimination of all food sources of MSG resulted in decreased headache frequency. Information and food lists helpful in identifying dietary MSG and HVP are presented. When patients are put on an MSG‐free trial diet, mention needs to be given to identification of the wide variety of foods containing MSG and HVP.
The Relationship Between MMPI Cluster Membership and Diagnostic Category in Headache Patients
Authors: Robinson Michael E. , Geisser Michael E. , Dieter John N. , Swerdlow Bernard 
Published: May 2005

SYNOPSISOnly one study has examined MMPI cluster profiles in the headache population. The present study expanded on this previous investigation by using a large sample size (N=485) and a greater number of diagnostic categories. The five MMPI clusters replicated previous findings in the chronic pain literature. These MMPI cluster groups were compared to 5 diagnostic categories (migraine, cluster, post‐trauma, tension, mixed). No relationship was found between cluster type and headache diagnosis. While the diagnostic groups were found to differ on measures of pain severity, sex and age, cluster groups did not. It is proposed that MMPI scale types reflect a patient's response to pain and are more likely to be the result of coping resources than headache‐related personality style. Future research with additional, non‐painpopulations and prospective studies is suggested.
The Association of Frequent Headaches with Personality and Life Events
Authors: Passchier J. , Schouten J. , van der Donk J. , van Romunde L.K.J. 
Published: May 2005

SYNOPSISThe associations between personality traits, life events and frequent headaches were studied in a sample of 5766 adult subjects between 20 and 65 years of age from the general population. Subjects with at least weekly headaches had more life events and higher inadequacy, social inadequacy, rigidity and injuredness than subjects with less frequent headaches. These relationships were not observed in subjects of 50 years of age and older, with the exception of the association with inadequacy. From the traits measured, inadequacy had the highest odds ratios for frequent headaches and showed a modest interaction with the presence of a life event. These findings are in agreement with Sarason's interactional model.
Sexual Headaches: Case Report, Review, and Treatment with Calcium Blocker
Authors: Akpunonu Basil E. , Ahrens JoDee 
Published: May 2005

SYNOPSISA case is reported in which a patient with sexual and orgasmic headaches was treated successfully with a calcium channel blocker, diltiazem. To the best of our knowledge, this is the first case of successful treatment of sexual headaches with calcium channel blockers reported in the English medical literature. The literature on sexually related headaches is reviewed, and classification, evaluation, differential diagnosis, pathophysiology, differential diagnosis, and treatment of sexual headaches are discussed.
The Effect of Hyperventilation in Cluster Headache Patients
Authors: Antonaci Fabio , Zhao Jing‐Ming , Schaanning Jan , Sand Trond , Sjaastad Ottar 
Published: May 2005

SYNOPSISThe effect of voluntary hyperventilation was assessed in 22 cluster headache patients (8 in a cluster period and14 in a remission) and 19 healthy individuals. Using an ear oximeter and a capnograph with a nasal probe, the oxygen saturation (SaO2) and the end‐tidal CO2 were monitored continuously. During the hyperventilation per se, cluster headache patients and controls showed absolute values of end‐tidal CO2 and of SaO2 Of the Same order of magnitude. In the posthyperventilation phase, however, the average of the lowest SaO2 levels was lower in controls than in cluster headache patients. In the posthyperventilation phase, headache patients outside the cluster period showed a trend more similar to that of the controls with respect to SaO2 than did those inside the cluster period. The observed discrepancy might, if reproducible, be a consequence of an altered chemoreceptor sensitivity in cluster headache patients during the bout.
Plasma and Saliva Levels of PGI2 and TXA2 in the Headache‐Free Period of Classical Migraine Patients. The Effects of Nicardipine
Authors: Puig‐Parellada R , Planas J,M. , Giménez J. , Sánchez J. , Gaya J. , Tolosa E. , Obach J. 
Published: May 2005

SYNOPSISThe levels of Prostacyclin (PGI2 ) and Thromboxane A2 (TXA2 ) were assayed simultaneously (RIA) in the plasma and saliva of 9 patients suffering from classical migraine attacks. The assays were done during an attack‐free period. In relation to the control group we observed a significant decrease in the plasma levels of PGI2 together with a sharp increase in TXA2 in saliva. When the patients were treated with nicardipine, a calcium antagonist, the TXA2 increase in saliva did not occur. These results suggest both a systemic and local effect in the classical migraine attacks. We explain and discuss our results by referring to the PGI2 : TXA2 equilibrium system. Nicardipine action might be related to its ability to reduce the calcium entry into the cell induced by thromboxane.