bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Severe Obesity Among Children Aged 2 to 4 Years in WIC: 2010 to 2020
Authors: Zhao Lixia , Freedman David S. , Blanck Heidi M. , Park Sohyun 
Published: December 2023

OBJECTIVESTo examine the prevalence and trends in severe obesity among 16.6 million children aged 2 to 4 years enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) from 2010 to 2020.METHODSSevere obesity was defined as a sex-specific BMI for age ≥120% of the 95th percentile on the Centers for Disease Control and Prevention growth charts or BMI ≥35 kg/m2. Joinpoint regression was used to identify when changes occurred in the overall trend. Logistic regression was used to compute the adjusted prevalence differences between years controlling for sex, age, and race and ethnicity.RESULTSThe prevalence of severe obesity significantly decreased from 2.1% in 2010 to 1.8% in 2016 and then increased to 2.0% in 2020. From 2010 to 2016, the prevalence decreased significantly among all sociodemographic subgroups except for American Indian/Alaska Native (AI/AN) children. The largest decreases were among 4-year-olds, Asian/Pacific Islander and Hispanic children, and children from higher-income households. However, from 2016 to 2020, the prevalence increased significantly overall and among sociodemographic subgroups, except for AI/AN and non-Hispanic white children. The largest increases occurred in 4-year-olds and Hispanic children. Among 56 WIC agencies, the prevalence significantly declined in 17 agencies, and 1 agency (Mississippi) showed a significant increase from 2010 to 2016. In contrast, 21 agencies had significant increases, and only Alaska had a significant decrease from 2016 to 2020.CONCLUSIONSAlthough severe obesity prevalence in toddlers declined from 2010 to 2016, recent trends are upward. Early identification and access to evidence-based family healthy weight programs for at-risk children can support families and child health.
Three-dimensional (3D) transthoracic echocardiography in Cor Triatriatum Sinister: Make new friends but keep the old
Authors: Basile Paolo , Santoro Daniela , Guaricci Andrea Igoren 
Published: December 2023

AbstractCor Triatriatum Sinister (CTS) represents a rare congenital cardiac defect characterized by the presence of a fibro-muscular membrane separating the left atrium into two cavities. During adulthood CTS may be asymptomatic and incidentally found during imaging diagnostic workflow. Bidimensional (2D) transthoracic echocardiography (TTE) is considered the first-line imaging technique for the evaluation of CTS. Cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TEE) are advanced diagnostic tools, usually required to obtain additional data. When these diagnostic techniques are contraindicated or not available, three-dimensional (3D) TTE may provide useful information which may help in the morphological assessment of CTS. Moreover, this widespread technique is safe and frequently available in the echocardiography laboratories, although the acoustic window and the training of the operator may be limiting factors. With this case report we sought to emphasize the usefulness of this technique as a valid alternative to CMR and TEE in selected settings.
A Experiência do Design Thinking na Educação a Distância
Authors: Filla Claudia Leticia , Soares Augusto Codevilla , Utime Letícia 
Published: December 2023

O presente artigo explora a experiência do usuário na Educação a Distância por meio das metodologias do Design Thinking em busca de soluções de problemas complexos, sejam eles em produtos digitais ou em serviços. Utilizando os processos de UX Design e Design de Serviços, são demonstrados projetos desenvolvidos na Gerência Executiva de Educação do . O olhar para o foco nas pessoas, foi a premissa dos projetos aqui citados para a ideação de soluções mais assertivas nos desafios educacionais do ensino a distância.
Molecular profile of Epstein–Barr virus in representatives of four ethnic groups of Russia: virus types, <i>LMP1</i> gene variability and malignancies
Authors: Smirnova K.  V. , Lubenskaya A. K. , Senyuta N. B. , Dushenkina T. E. , Gurtsevitch V. E. 
Published: December 2023

Rationale. The discovery of two Epstein–Barr virus (EBV) types, EBV-1 and EBV-2, which differ in their transforming abilities stimulated their study in various populations in order to elucidate the relationship with malignant neoplasms.Aim. To study EBV-1 and EBV-2 in representatives of four ethnic groups of Russia, sequence analysis of the LMP1 oncogene in virus isolates, and search for a correlation between the types of EBV and the incidence of certain types of malignant tumors in four ethnic groups.Materials and methods. From total DNA obtained from oral washings of Adygeans, Kalmyks, Tatars and Slavs, representatives of 3 Russian republics and the Moscow region, EBV DNA was amplified; its presence and concentration were analyzed by nested PCR, and each product was examined for the virus type and LMP1 variant. Types of EBV found in representatives of In four ethnic groups were compared with the incidence rates of malignant tumors, among which EBV-associated cases may occur, in population of three republics and the Moscow region.Results. It was observed that higher gastric cancer and lymphomas morbidity among Tatarstan and Moscow region populations (compared to populations of Adygea and Kalmykia) correlated with predominance in these ethnic groups – Tatars and Slavs – EBV-1 type having transforming potential in vitro. In Adygeis, non-transforming EBV-2 type was prevalent, and Kalmyks were infected with both types in approximately equal proportion. however, differences between tumor morbidities between the compared groups were statistically insignificant (p >0.05). The identified spectrum of LMP1 variants, as well as the results of their sequencing, show genetic relations between EBV strains circulating in the studied ethnic groups.Conclusion. Study of EBV isolates for the first time performed in 4 ethnic groups of this country showed differences in distribution of the types of this virus but there was no correlation with tumor morbidity.
Transcriptomic analysis of neural stem and progenitor cells in comparison with glioblastoma stem cells
Authors: Shevchenko V. E. , Arnotskaya N. E. , Kushnir T.  I. , Bryukhovetskiy A. S. 
Published: December 2023

Introduction. There is currently no effective therapy for the treatment of glioblastoma. This is partly explained by the high degree of intra- and intertumor heterogeneity of GB, the source of which is believed to be glioblastoma stem cells (GSC). The question of the origin of GSC, which is important for improving clinical outcomes, still remains open. It is believed that GSCs can be formed as a result of oncogenic transformation of neural stem and progenitor cells (NSPcs), which have morphological and functional properties similar to them. Despite significant progress in elucidating the nature of GSCs, little is yet known about the specifically expressed genes and transcripts in these cells in comparison with NSPcs. In this regard, it becomes relevant to study the molecular mechanisms of gliomagenesis using model cell systems based on various clones of GSC.Aim. To conduct a comparative transcriptomic analysis of CD133+-NSPCs and CD133+-GSCs to study the molecular genetic differences between the phenotypes of these cells and identify potential targets for therapeutic effects on GSCs.Materials and methods. Used: highly sensitive transcriptomic analysis on high-density microarrays, cellular technologies, modern bioinformatics analysis.Results. Transcriptomic analysis of CD133+-GSCs and CD133+-NSPCs identified 1825 differentially expressed genes. The biological processes and signaling cascades activated in CD133+-GSCs have been established. It was shown that significant transcriptomic aberrations in CD133+-GSC compared to CD133+-NSPC are primarily due to a group of transcripts regulated by the Shh (Sonic hedgehog), mTOR (mammalian target of rapamycin), ALK (anaplastic lymphoma kinase) signaling cascades, transcription factors E2F1, PRC2, HOXA9, MYC, as well as oncogenes ERBB2 and KRAS. Six transcripts (AQP9, TOX15, HOXB2, STEAP3, TREM1, RFC2) highly expressed in CD133+-GSC and closely associated with the survival of patients with glioblastoma, which may be potential targets for therapeutic effects on CD133+-GSC associated with gliomagenesis, which may be potential targets for therapeutic effects on CD133+-GSC, have been identified and annotated.Conclusion. The data obtained indicate a number of significant molecular genetic differences between the two cell phenotypes, which can be used in the development of new therapeutic approaches for the treatment of glioblastoma.
Analysis of the expression of matrix RNA of a panel of genes of morphologically unchanged rectal epithelium as a method of early diagnosis of colon pathology
Authors: Bozhenko V.  C. , Goncharov S. V. , Zakharenko M. V. , Kiseleva Ya.  Yu. , Karmakova T. A. , Kulinich T.  M. , Stanoevich U. S. , Melnikova N.  V. , Senchukova A. L. , Grunin I.  B. , Bliznyukov O.  P. , Solodky V. A. 
Published: December 2023

Introduction. The absence of specific clinical symptoms in the early stages of colorectal cancer development leads to the fact that a quarter of patients who seek help for the first time have a metastatic stage of the disease. For the timely detection of pre-tumor disorders or hidden foci of malignancy, the possibilities of modern molecular biological technologies are being actively studied today.Aim. To develop a method for diagnosing tumor diseases of the colon based on molecular genetic analysis of morphologically unchanged intestinal epithelium distant from the focus of the tumor lesion.Materials and methods. We examined the matrix RNA (mRNA) expression profile of 63 candidate genes potentially associated with the pathogenesis of neoplastic changes in rectal mucosal samples. Samples were obtained during prophylactic and/or diagnostic video colonoscopy of 122 patients, 41 of whom had no history of breast cancer (“Normal”), 32 patients were diagnosed with breast cancer polyps (“Polyposis”) and 49 patients were diagnosed with breast cancer (“colorectal cancer”). mRNA expression was assessed by reverse transcription polymerase chain reaction.Results. Using the discriminant analysis method, it was established that the cellular material of scrapings from the rectum in the “colorectal cancer” group reliably, with a classification accuracy above 96 %, differs in expression phenotype from the “Normal” and “Polyposis” groups.Conclusion. The data obtained are a prerequisite for the development of a minimally invasive diagnostic method that can be used as part of an outpatient examination to assess the risk of colon tumor disease.
PROMOTING COMPANYS „X” PRODUCT ON „FACEBOOK” PLATFORM
Authors: Lūse Dana 
Published: December 2023

At a time when the popularity of social networks has greatly outgrown traditional media resources and the number of users is steadily increasing, companies have shown a number of new ways of reaching customers and informing about their products or services.
The main advantages of social networks in business are their speed and simplicity. In addition, social networks, such as „Facebook”, collect a lot of information about users at user registration on social network, which makes it easier for companies to search for their potential customer. Apart from the resources, it is possible to promote product on „Facebook” social network in an economic way without actually spending money. It is important for companies to know all „Facebook” network possibilities of promoting product without big investments.
Papillary thyroid microcarcinoma: impossible to operate observe – where to put a comma?
Authors: Afanasyeva Z. A. , Vasilevskaya S. M. , Druzhkova N. B. , Сhernyshov V. A. , Saveliev V. V. , Khamzina F. T. , Muzafarova F. K. , Gazizov R. R. , Sabirov A. G. 
Published: December 2023

Objective. To evaluate the efficiency of diagnostics and treatment in patients with microcarcinomas of the thyroid gland at the State Medical Institution "RCOD of the Ministry of Health of the Republic of Tatarstan named after Professor. M.Z. Sigal" for 2020-22.
Materials and methods. MIS "BARS. Healthcare – MIS" of oncological dispensary, outpatient charts and medical histories of patients operated on for thyroid microcarcinomas were used.
Results. In the study group, all patients had papillary microcarcinoma. Women over 45 years of age prevailed. Women of fertile age accounted for 41.7%. The combination of microcarcinoma with thyroid adenomas, colloidal goiter and AIT was detected in 78.6% of patients. The organ capsule invasion occurred in 35.7% of patients, metastases to regional lymph nodes – in 19%. Thyroidectomy was performed in 66.7% of patients; 12 (28.6%) patients underwent I-131 therapy.
Conclusions. Due to the fact that papillary microcarcinoma of the thyroid gland is often found in women of fertile age, and develops against the background of another thyroid pathology complicating diagnostics, it sprouts an organ capsule in 35.7% and gives metastases to regional lymph nodes in 19%, therefore requires a timely diagnostics and radical treatment.
Serological profile of IGG antibodies to viral capsid antigen of epstein-barr virus in oral pre-cancer and cancer patients
Authors: Jonathan Daniel M , Jimsha VK , Ganapathy KS , Mohan CV 
Published: December 2023

Cancer of the oral cavity is a major and increasing public health problem. Oral cancer is the sixth most common cancer reported globally with an annual incidence of over 300,000 cases, of which 62% arise in developing countries. In India, because of cultural, ethnic, and geographic factors and the popularity of addictive habits, the frequency of oral cancer is high. Despite the various etiological and predisposing factors associated with oral pre-cancer and cancer, the role of co-carcinogenic effects of viruses like HSV has been documented. With this background and considering the high prevalence of oral cancer in India an attempt has been made to study the association of EBV with oral cancer using serological methods.1. To study the IgG antibodies to Viral Capsid Antigen (VCA) of Epstein-Barr virus in oral pre-cancer and cancer by a laboratory standardized Indirect Immuno Fluorescent (IIF) test. 2. To compare and corelate the results of IIF test with a commercially available ELISA for VCA IgG antibodies to EBV. 3. To assess the severity of disease progression in oral pre-cancer and cancer using the serological profile.In the present study, 84 subjects were assessed for serum IgG antibodies to VCA of EBV using the IIF technique and later the results were compared with an ELISA kit. Group I were controls, Group II to Group V were oral squamous cell carcinoma subjects according to the clinical staging. Group VI comprised of oral pre-cancer subjects. Age range was between 40-70 years, and the mean age was 50.31 +/- 8.23 years. All the 42 control sera were positive for IgG antibodies to VCA of EBV but with a significantly low geometric mean titre(GMT) of 8.561.The GMTs of oral squamous carcinoma and pre-cancer sera was positive but progressively increased when compared to control sera and were highly significant (P&#60;0.001).As there was a significant increase in the GMTs in oral squamous cell carcinoma subjects and pre-cancer subjects, serology of EBV may be interpreted to be useful in assessing the severity of the disease and the techniques of IIF and ELISA may be used as first line screeners when large number of subjects need to be assessed.
Identification of Sarcocystis spp. in Hamburgers Distributed in Fouman City, North of Iran Using Dab Smear and Digestion Methods
Authors: Ahmadiara Emad , Rahimzadeh Amin , Samakkhah Shohreh Alian 
Published: December 2023

Introduction: Human infection with Sarcocystis species can be attributed to the consumption of raw or inadequately cooked meat, such as hamburgers, containing encapsulated parasites.
Materials and Methods: This cross-sectional study was conducted between April and September 2022 in Fouman, Iran. A total of 182 hamburger samples, comprising two types of traditional hamburgers and industrial hamburgers, were collected.
Result: Out of 182 hamburger samples of different types, 34% of them were found to be infected with Sarcocystis spp. The infection rate within industrial and traditional hamburgers was 21.5% and 56%, respectively. Notably, a statistically significant difference was observed between Sarcocystis-infested traditional and industrial hamburgers (p < 0.05). Among the two distinct groups of 182 hamburgers, the microscopic digestion method revealed the presence of Sarcocystis bradyzoites in all 51 infected traditional beef burgers and 19 positive industrial beef burgers. However, in the dab smear method, just 33 and 12 positive samples were respectively identified in traditional and industrial beef burgers and a statistically significant difference was observed between efficiency of these two methods (p < 0.05). Infection with macroscopic parasite cysts was not observed in any of hamburger samples. Similarly, no statistically significant association was identified between the meat content percentage and the infection rate in industrial hamburgers (p > 0.05).
Conclusion: Considering the high abundance of Sarcocysts micro cysts in frozen raw hamburgers, it is recommended to fully cook this food product and avoid consumption when only partially cooked.
Resepsi atas Islam Moderat: Antara Kritik dan Sikap yang Representatif
Authors: Benny Afwadzi  
Published: December 2023

Until now, many rejections of the terminology of Islam Nusantara have emerged, not only among the general public, but also in the academic environment. In fact, moderate Islam is a means to tackle extremism, radicalism, and terrorism. Therefore, a systematic description of what is meant by moderate Islam is needed from various literatures. It is for this purpose that this article was written. With a qualitative approach and the type of literature research on works related to moderate Islam, it was found that moderate Islam must be understood with middle Islam, not extreme right or left. Although in Western literature, moderate is synonymous with liberal and secular, but a representative attitude is to filter what comes from the West. Not everything that comes from the West must be accepted, and not all must be rejected, as well as the terminology of moderate Islam. Even the arguments against moderate Islam, if analyzed, have a fundamental weakness, because they are not in accordance with the spirit of moderate Islam. The basis for the foundation of moderate Islam is clear, namely Q.S. al-Baqarah [2]: 143, so it has a normative basis that can be accounted for. Furthermore, Islam in the archipelago is essentially a representation of moderate Islam, although it must be admitted that not all adherents are moderate.
(Sampai saat ini, penolakan terhadap terminologi Islam Nusantara banyak bermunculan, tidak hanya di kalangan masyarakat awam, namun juga di lingkungan akademik. Padahal, Islam moderat adalah sarana untuk menanggulangi ekstremisme, radikalisme, dan terorisme. Oleh sebab itu, diperlukan uraian yang sistematis terkait apa yang dimaksud dengan Islam moderat dari berbagai literatur. Untuk tujuan itulah artikel ini ditulis. Dengan pendekatan kualitatif dan jenis penelitian pustaka terhadap karya-karya terkait Islam moderat, ditemukan bahwa Islam moderat haruslah dipahami dengan Islam pertengahan, tidak ekstrem kanan maupun kiri. Meskipun dalam literatur Barat, moderat identik dengan liberal dan sekuler, akan tetapi sikap yang repreentatif adalah dengan melakukan filterisasi terhadap apa yang datang dari Barat. Tidak semua yang datang dari Barat harus terima, dan tidak pula semua pula harus ditolak, begitu pula terminologi Islam moderat. Argumen-argumen penolak Islam moderat pun, jika dianalisis, mempunyai kelemahan yang mendasar, karena tidak sesuai dengan semangat Islam moderat. Dasar pijakan Islam moderat pun jelas, yakni Q.S. al-Baqarah [2]: 143, sehingga mempunyai landasan normatif yang bisa dipertanggungjawabkan. Lebih lanjut, Islam yang ada di Nusantara ini pada hakikatnmya merupakan representasi Islam moderat, meski harus diakui bahwa tidak semua penganutnya berpaham moderat.)
Portrait of Islamic Religious Education in Public Universities in the 5.0 Era
Authors: Bachrul Ulum  , Mohammad Hasib  , Moh. Zaini  
Published: December 2023

In the 5.0 era, Islamic religious instruction in higher education is crucial as in forming students' morality and character. With a correct and deep understanding of religion, students can internalize these values in their daily lives and make good and responsible decisions. The article's aim is to give an outline of the Islamic religious teaching and learning processes in public colleges as of 5.0. A qualitative research methodology was adopted, and instructors and students were interviewed as well as observed to obtain data involved in the learning and teaching process of Islam in public universities. Then, content analysis is used to assess the acquired data utilizing qualitative data analysis techniques. The findings indicated that there is still room for improvement in the standard of Islamic religious instruction in public universities, especially in terms of subpar teaching and learning. Lack of emphasis on character education, poor teaching, and minimal use of technological in the process of learning and instruction are some of the reasons that contribute to the poor quality of Islamic religious education in public universities. Thus, character education, raising the bar of instruction, and implementing better technology in the learning and teaching process of Islam in the 5.0 era are necessary to improve the quality of Islamic religious instruction in public universities.
(Di era 5.0, pengajaran agama Islam di perguruan tinggi menjadi sangat penting dalam membentuk moralitas dan karakter mahasiswa. Dengan pemahaman agama yang benar dan mendalam, mahasiswa dapat menginternalisasi nilai-nilai tersebut dalam kehidupan sehari-hari dan mengambil keputusan yang baik dan bertanggung jawab. Artikel ini bertujuan untuk memberikan gambaran umum tentang proses pengajaran dan pembelajaran agama Islam di perguruan tinggi umum di era 5.0. Metodologi penelitian kualitatif diadopsi, dan para pengajar serta mahasiswa diwawancarai serta diobservasi untuk mendapatkan data yang terlibat dalam proses belajar dan mengajar agama Islam di perguruan tinggi umum. Kemudian, analisis isi digunakan untuk menilai data yang diperoleh dengan menggunakan teknik analisis data kualitatif. Temuan penelitian menunjukkan bahwa masih ada ruang untuk perbaikan dalam standar pengajaran agama Islam di perguruan tinggi umum, terutama dalam hal pengajaran dan pembelajaran yang masih di bawah standar. Kurangnya penekanan pada pendidikan karakter, pengajaran yang buruk, dan minimnya penggunaan teknologi dalam proses belajar mengajar merupakan beberapa alasan yang berkontribusi terhadap rendahnya kualitas pendidikan agama Islam di universitas umum. Oleh karena itu, pendidikan karakter, peningkatan standar pengajaran, dan penerapan teknologi yang lebih baik dalam proses pembelajaran dan pengajaran agama Islam di era 5.0 sangat diperlukan untuk meningkatkan kualitas pengajaran agama Islam di perguruan tinggi umum.)