bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing housing supply location choice: a comparative study of the modelling frameworks
Authors: Zhang Yu , Miller Eric J. 
Published: January 2024

AbstractThe purpose of this study is to predict the location of new housing supply and compare two different modelling frameworks. Housing supply significantly influences land use simulations in urban microsimulation systems, closely linked with demographic, transportation, and environmental modules. The supply of new dwellings in urban simulation models have evolved from static, exogenous inputs to dynamic, agent-based determinations. This study follows this trend to examine two approaches to modelling the spatial distribution of new housing supply: the first approach models the development choice of each location; the second approach models the location choice of each residential project. Multinomial logit and nested logit models are applied to a Toronto empirical dataset. The results show that although the first approach achieves higher goodness-of-fit and prediction accuracy, the second approach performs better in explaining the locational preference of individual projects. Project characteristics such as structure type and construction cost, as well as location characteristics such as housing price, number of sales, and population density affect the spatial distribution of new housing supply. Both approaches are evaluated regarding estimation, prediction, and microsimulation system integration. The findings enhance housing modelling literature and inform urban microsimulation’s housing supply model configuration.
A study on matching supply and demand of ecosystem services in the Hexi region of China based on multi-source data
Authors: Zhang Xuebin , Li Xuehong , Wang Ziyang , Liu Yue , Yao Litang 
Published: January 2024

AbstractTo achieve the best management of the ecosystem and sustainable socioeconomic development, it is crucial to clarify the matching relationship between the supply and demand of ecosystem services (ESs). Four types of ESs were chosen for the Hexi region in this study: food supply, carbon sequestration, water yield, wind erosion control and sediment retention. We assessed the supply–demand and matching relationships of different ESs using the Integrated Valuation of Ecosystem Service and Tradeoffs (InVEST) model, the ESs supply–demand ratio and the four-quadrant model. Moreover, we also analyzed the supply–demand ratio of integrated ESs and their cold spots. The findings suggest that (1) from 2000 to 2020, the average supply of food supply, carbon sequestration, water yield, wind erosion control and sediment retention increased by 44.31 t/km2, 128.44 t/hm2, 14,545.94 m3/km2 and 0.14 kg/m2 respectively, which showed a spatial pattern of “high in the southeast and low in the northwest”. The average demand for food supply and carbon sequestration increased by 1.33 t/km2 and 0.32 t/hm2 respectively, while the average demand for water yield and wind erosion control and sediment retention decreased by 2997.25 m3/km2 and 1.19 kg/km2 respectively. The spatial distribution is consistent with the layout of population density, production and residential areas, and fragile ecological areas. (2) The supply–demand ratio of food supply, carbon sequestration and water yield is greater than 0.095, which is in a state of oversupply, and the supply–demand ratio of wind erosion control and sediment retention is less than 0, which is in a state of shortage; all ESs are mainly in low-low spatial matching areas, mainly concentrated in the desert areas of the northwest in the Hexi region. (3) The supply–demand ratio of integrated ESs increased by 0.024, and the proportion of cold spots and sub-cold spots was more than 50% and concentrated in the northwest, while hot spots and sub-hot spots accounted for only about 16%, mainly distributed in the southern Qilian Mountains and some oasis areas.
Advancing tuberculosis diagnosis and management in cynomolgus macaques using Xpert MTB/RIF ultra assay
Authors: Srilohasin Prapaporn , Warit Saradee , Prammananan Therdsak , Smithtikarn Saijai , Kanitpun Reka , Kaewparuehaschai Mutchamon , Noradechanon Kirana , Meesawat Suthirote , Thakaew Nattakan , Sakulwittayasuk Nonthakorn , Kemthong Taratorn , Palaga Tanapat , Malaivijitnond Suchinda , Chaiprasert Angkana 
Published: January 2024

AbstractThe detection and management of Mycobacterium tuberculosis complex (MTBC) infection, the causative agent of tuberculosis (TB), in macaques, including cynomolgus macaques (Macaca fascicularis), are of significant concern in research and regions where macaques coexist with humans or other animals. This study explored the utility of the Xpert MTB/RIF Ultra assay, a widely adopted molecular diagnostic tool to diagnose tuberculosis (TB) in humans, to detect DNA from the Mycobacterium tuberculosis complex in clinical samples obtained from cynomolgus macaques. This investigation involved a comprehensive comparative analysis, integrating established conventional diagnostic methodologies, assessing oropharyngeal-tracheal wash (PW) and buccal swab (BS) specimen types, and follow-up assessments at 3-month, 6-month, and 12-month intervals. Our results demonstrated that the Xpert MTB/RIF Ultra assay was able to detect MTBC in 12 of 316 clinical samples obtained from cynomolgus macaques, presenting a potential advantage over bacterial culture and chest radiographs. The Xpert MTB/RIF Ultra assay exhibited exceptional sensitivity (100%) at the animal level, successfully detecting all macaques positive for M. tuberculosis as confirmed by traditional culture methods. The use of PW samples revealed that 5 positive samples from 99 (5.1%) were recommended for testing, compared to 0 samples from 99 buccal swab (BS) samples (0.0%). In particular, the definitive diagnosis of TB was confirmed in three deceased macaques by MTB culture, which detected the presence of the bacterium in tissue autopsy. Our findings demonstrate that the implementation of the Xpert MTB/RIF Ultra assay, along with prompt isolation measures, effectively reduced active TB cases among cynomolgus macaques over a 12-month period. These findings highlight the advance of the Xpert MTB/RIF Ultra assay in TB diagnosis and its crucial role in preventing potential outbreaks in cynomolgus macaques. With its rapidity, high sensitivity, and specificity, the Xpert MTB/RIF Ultra assay can be highly suitable for use in reference laboratories to confirm TB disease and effectively interrupt TB transmission.
Artificial neural network analysis for classification of defected high voltage ceramic insulators
Authors: Haiba Ahmed S. , Eliwa Gad A. 
Published: January 2024

AbstractPartial discharge (PD) could lead to the formation of small arcs or sparks within the insulating material, which can cause damage and degradation to the insulator over time. In ceramic insulators, there are several factors that can cause PD including manufacturing defects, aging, and exposure to environmental conditions such as moisture and temperature extremes. As a result, detecting and monitoring PD in ceramic insulators is important for ensuring the reliability and safety of electrical systems that rely on these insulators. In this study, acoustic emission technique is introduced for PD detection and condition monitoring of defective ceramic insulators. A sequence of data processing techniques is performed on the captured signals to extract and select the most significant signatures for classification of defects in insulator strings. Artificial neural network (ANN) has been used to build an intelligent classifier for easily and accurately classification of defective insulators. The overall recognition rate of the classifier was obtained at 96.03% from discrete wavelet transform analysis and 88.65% from fast Fourier transform analysis. This obtained result indicates high accuracy and performance classification. The outcomes of ANN were verified by SVM and KNN algorithms.
Geographical and environmental patterns of Carpathian land snail faunas in a region of high endemicity
Authors: Gheoca Voichița , Benedek Ana Maria , Cameron Robert 
Published: January 2024

AbstractThe land snail faunas of limestone gorges of Romanian Carpathians were sampled to test the effect of geographic and environmental factors on the malacofauna richness and composition. A total of 134 sites within 28 limestone gorges were surveyed during 2011–2019 using a combined strategy of visual search and litter/topsoil analysis. Environmental variables such as geographic location, altitude, climate, microhabitat type, dominant vegetation, tree cover and width of the gorge were recorded to detect the relationship with species richness and composition. While the numbers of species, their identities and their abundance varied greatly among samples, both presence and absence data and quantitative multivariate analyses showed that region and climate or altitude (both strongly associated with region) accounted for far more variation than differences in tree cover and dominant microhabitat. Nevertheless, the effects of different habitat preferences were evident. The mixture of species with very restricted ranges within this Pleistocene refugium and those that have spread widely during the Holocene raise questions about the meaning of region when related to local richness and composition.
Unveiling breast cancer metastasis through an advanced X-ray imaging approach
Authors: Conceição Andre L. C. , Müller Volkmar , Burandt Eike-Christian , Mohme Malte , Nielsen Leonard C. , Liebi Marianne , Haas Sylvio 
Published: January 2024

AbstractBreast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interventions. Changes in the extracellular matrix play a pivotal role in breast cancer metastasis. In this work, we present an advanced multimodal X-ray computed tomography, by combining Small-angle X-ray Scattering Tensor Tomography (SAXS-TT) and X-ray Fluorescence Computed Tomography (XRF-CT). This approach likely brings out valuable information about the breast cancer metastasis cascade. Initial results from its application on a breast cancer specimen reveal the collective influence of key molecules in the metastatic mechanism, identifying a strong correlation between zinc accumulation (associated with matrix metalloproteinases MMPs) and highly oriented collagen. MMPs trigger collagen alignment, facilitating breast cancer cell intravasation, while iron accumulation, linked to angiogenesis and vascular endothelial growth factor VEGF, supports cell proliferation and metastasis. Therefore, these findings highlight the potential of the advanced multimodal X-ray computed tomography approach and pave the way for in-depth investigation of breast cancer metastasis, which may guide the development of novel therapeutic approaches and enable personalised treatment strategies, ultimately improving patient outcomes in breast cancer management.
Reduction of discrepancies between students and instructors in the assessment of practical tasks through structured evaluation sheets and peer feedback
Authors: Bizhang Mozhgan , Adib Shaban Havre , Vahlenkamp Andreas , Zimmer Stefan , Möltner Andreas , Ehlers Jan 
Published: January 2024

AbstractThe aim of this study was to reduce discrepancies between students and instructors in a preclinical dental course by employing structured peer feedback based on a detailed evaluation sheet. In a crossover study of dental students (n = 32), which compared peer feedback using an evaluation sheet (test) with the traditional method (control), participants completed tasks involving cavity and partial crown preparation. The practical tasks were scored numerically on a scale ranging from one (excellent) to six (failure). The amount of feedback provided by the instructor was also recorded. Statistical analysis was conducted using Wilcoxon signed-rank tests (p < 0.05). Regarding cavity preparation, no statistically significant difference was observed (median (25th–75th percentile)) between the grades received by the test (2.00 (1.50–3.00)) and control groups (2.25 (2.00–3.00)). However, the grades pertaining to partial crown preparation exhibited a statistically significant difference between the test (2.25 (2.00–2.50)) and control (2.50 (2.00–3.00)) groups. LimeSurvey and five-finger feedback were used to assess satisfaction with the new method, revealing that most students found the evaluation sheet and peer feedback to be effective. Within the limitations of this study, structured peer feedback using the evaluation sheet positively impacted grades pertaining to partial crown preparation, requiring less instructor feedback.
The natural breakthrough: phytochemicals as potent therapeutic agents against spinocerebellar ataxia type 3
Authors: Naveed Muhammad , Ali Nouman , Aziz Tariq , Hanif Nimra , Fatima Mahnoor , Ali Imran , Alharbi Metab , Alasmari Abdullah F. , Albekairi Thamer H. 
Published: January 2024

AbstractThere is no FDA-approved drug for neurological disorders like spinocerebellar ataxia type 3. CAG repeats mutation in the ATXN3 gene, causing spinocerebellar ataxia type 3 disease. Symptoms include sleep cycle disturbance, neurophysiological abnormalities, autonomic dysfunctions, and depression. This research focuses on drug discovery against ATXN3 using phytochemicals of different plants. Three phytochemical compounds (flavonoids, diterpenoids, and alkaloids) were used as potential drug candidates and screened against the ATXN3 protein. The 3D structure of ATXN3 protein and phytochemicals were retrieved and validation of the protein was 98.1% Rama favored. The protein binding sites were identified for the interaction by CASTp. ADMET was utilized for the pre-clinical analysis, including solubility, permeability, drug likeliness and toxicity, and chamanetin passed all the ADMET properties to become a lead drug candidate. Boiled egg analysis attested that the ligand could cross the gastrointestinal tract. Pharmacophore analysis showed that chamanetin has many hydrogen acceptors and donors which can form interaction bonds with the receptor proteins. Chamanetin passed all the screening analyses, having good absorption, no violation of Lipinski’s rule, nontoxic properties, and good pharmacophore properties. Chamanetin was one of the lead compounds with a − 7.2 kcal/mol binding affinity after screening the phytochemicals. The stimulation of ATXN3 showed stability after 20 ns of interaction in an overall 50 ns MD simulation. Chamanetin (Flavonoid) was predicted to be highly active against ATXN3 with good drug-like properties. In-silico active drug against ATXN3 from a plant source and good pharmacokinetics parameters would be excellent drug therapy for SC3, such as flavonoids (Chamanetin).
The relationship between physical performance and alcohol consumption levels in Russian adults
Authors: Mitkin Nikita A. , Kirilkin German E. , Unguryanu Tatiana N. , Malyutina Sofia , Cook Sarah , Kudryavtsev Alexander V. 
Published: January 2024

AbstractInvestigating the relationship between alcohol consumption and physical performance, we used data from the 2015–2018 Know Your Heart study on 4215 adults aged 35–69 from Arkhangelsk and Novosibirsk, Russia. We classified participants’ drinking status into non-drinking, non-problem drinking, hazardous drinking, and harmful drinking based on their self-reported drinking behaviors. To evaluate physical performance, we developed a Composite Physical Performance Scale (CPPS), which combined the results of three functional tests: grip strength (GS), closed-eyes balance, and chair rises (CR). We applied multivariable linear regression to assess the relationship between alcohol consumption and CPPS score, and ordinal logistic regression to explore the associations between alcohol consumption and the three functional tests separately. The results showed that harmful drinking was associated with lower CPPS scores compared to non-problem drinking. Among harmful drinking men, the decrease in CPPS scores was explained by all three tests equally and exceptionally by GS among women. Non-drinking was also associated with decreased CPPS, linked to lower GS and CR scores in men, and only lower GS scores in women. The study revealed a reduced physical performance in the non-drinking and harmful drinking groups compared to non-problem drinking.
Impact of serum eicosapentaenoic acid/arachidonic acid ratio on overall survival in lung cancer patients treated with pembrolizumab: a pilot study
Authors: Tanaka Ikue , Yano Yukihiro , Mori Masahide , Manabe Satoru , Fukuo Keisuke 
Published: January 2024

AbstractThis pilot study analyzed the dietary patterns of patients with non-small cell lung cancer undergoing initial pembrolizumab, an immune checkpoint inhibitor (ICI), treatment in the month before treatment. Serum fatty acid fractions and their associations with ICI treatment efficacy were also investigated. The results showed that long-term survivors (those who survived for ≥ 3 years) consumed significantly more seafood than short-term survivors (those who survived for < 3 years). Furthermore, the serum levels of eicosapentaenoic acid (EPA) as well as the ratio of EPA to arachidonic acid (EPA/AA) were higher in the long-term survivors than those in the short-term survivors. The group with a high serum EPA/AA ratio had a significantly higher overall survival rate after ICI treatment than the group with a low serum EPA/AA ratio. In conclusion, higher dietary seafood consumption may improve OS in lung cancer patients treated with ICI and the serum EPA/AA ratio may be a useful biomarker for determining the efficacy of ICI treatment. Thus, supplements that increase the serum EPA/AA ratio could serve as new nutritional interventions for enhancing the efficacy of ICI treatment. However, further large-scale case and intervention studies are required.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway
Authors: Yang Yuxin , Tang Xiangting , Yao Ting , Zhang Yiqing , Zhong Yufei , Wu Shuqing , Wang Yurou , Pan Zezheng 
Published: January 2024

AbstractPremature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment of POF damaged by chemotherapy drugs remains unclear. In this study, we investigated the impact of MET on POF caused by cyclophosphamide (CTX) combined with busulfan (BUS) and M1 macrophages using POF model mice and primary granule cells (GCs). Our findings demonstrate that intragastric administration of MET ameliorates ovarian damage and alleviates hormonal disruption in chemotherapy-induced POF mice. This effect is achieved through the reduction of inflammatory and oxidative stress-related harm. Additionally, MET significantly relieves abnormal inflammatory response, ROS accumulation, and senescence in primary GCs co-cultured with M1 macrophages. We also observed that this protective role of MET is closely associated with the AMPK/PPAR-γ/SIRT1 pathway in cell models. In conclusion, our results suggest that MET can protect against chemotherapy-induced ovarian injury by inducing the expression of the AMPK pathway while reducing oxidative damage and inflammation.
Effects of elastic taping on kyphosis and body balance in the elderly: a randomized crossover study
Authors: Tangpakkakul Surapa , Manimmanakorn Nuttaset , Manimmanakorn Apiwan , Vichiansiri Ratana , Hamlin Michael J. 
Published: January 2024

AbstractKyphosis produces abnormal posture and reduced body balance in the elderly. Elastic tape may be useful at improving kyphotic posture and body balance. This study aims to evaluate the effects of elastic taping on kyphosis and body balance in the elderly. Ten elderly participants with degenerative kyphotic posture were recruited and randomly assigned to two groups (back taped with stretched elastic tape for 15 min and back taped with non-stretched elastic tape for 15 min). After a 1-h washout period, the groups were swapped over to receive the other intervention. The outcomes measured after each taping technique were Cobb’s angle measurement by inclinometer, perceived pain, and balance measurements by single leg stance test, time up and go test, center of gravity alignment (COG) and modified clinical test of sensory interaction on balance test (mCTSIB). There was a significant reduction in kyphotic angle and back pain in both the stretched and non-stretched taping groups (p < 0.05). We also found both taping techniques significantly reduced sway velocity on a foam surface with eyes closed and open (p < 0.05). However, there was no significant difference between taping groups for kyphotic angle, pain reduction or balance. The application of 15 min of stretched and non-stretched elastic tape in the elderly reduced kyphotic angle, back pain, and sway velocity while standing on foam surface in the mCTSIB test. If these changes persist over the long term (days and weeks) taping may be a useful intervention for elderly patients with kyphosis.
Kinetic and hydrogen production analysis in the sequential valorization of a Populus clone by cold alkaline extraction and pyrolysis
Authors: Lozano-Calvo S. , Loaiza J. M. , García J. C. , Tapias R. , López F. 
Published: January 2024

AbstractThis work employed a two-step biorefining process, consisting of a hemicellulose-rich liquor production through ultrasound-assisted cold alkaline extraction (CAE), followed by thermochemical treatment of the resultant solid phase. The post-CAE solid phase’s pyrolytic potential was assessed by application of thermogravimetric analysis (TGA) and Friedman’s isoconversional method, and also from hydrogen production. The solid phases remaining after the CAE treatment were more reactive than the untreated raw material. Notably, the alkali concentration employed in the first step was the individual variable most pronounced influence on their activation energy (Ea). Thus, at a degree of conversion α = 0.50, Ea ranged from 109.7 to 254.3 kJ/mol for the solid phases, compared to 177 kJ/mol for the raw material; this value decreased with rising glucan content. At maximal degradation, the post-CAE solid phases produced up to 15.57% v/v more hydrogen than did the untreated raw material.
The drivers of global news spreading patterns
Authors: Alipour Shayan , Di Marco Niccolò , Avalle Michele , Etta Gabriele , Cinelli Matteo , Quattrociocchi Walter 
Published: January 2024

AbstractThe web radically changed the dissemination of information and the global spread of news. In this study, we aim to reconstruct the connectivity patterns within nations shaping news propagation globally in 2022. We do this by analyzing a dataset of unprecedented size, containing 140 million news articles from 183 countries and related to 37,802 domains in the GDELT database. Unlike previous research, we focus on the sequential mention of events across various countries, thus incorporating a temporal dimension into the analysis of news dissemination networks. Our results show a significant imbalance in online news spreading. We identify news superspreaders forming a tightly interconnected rich club, exerting significant influence on the global news agenda. To further investigate the mechanisms underlying news dissemination and the shaping of global public opinion, we model countries’ interactions using a gravity model, incorporating economic, geographical, and cultural factors. Consistent with previous studies, we find that countries’ GDP is one of the main drivers to shape the worldwide news agenda.