bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full Scale of Pore-Throat Size Distribution and Its Control on Petrophysical Properties of the Shanxi Formation Tight Sandstone Reservoir in the North Ordos Basin, China
Authors: Liu Kai , Wang Ren , Shi Wanzhong , Martín-Martín Juan Diego , Qi Rong , Zhang Wei , Qin Shuo , Travé Anna 
Published: January 2024

Abstract
Pore-throat size distribution is a key factor controlling the storage capacity and percolation potential of the tight sandstone reservoirs. However, the complexity and strong heterogeneity make it difficult to investigate the pore structure of tight sandstone reservoirs by using conventional methods. In this study, integrated methods of casting thin section, scanning electron microscopy, high-pressure mercury intrusion (HPMI), and constant-pressure mercury intrusion (CPMI) were conducted to study the pore-throat size distribution and its effect on petrophysical properties of the Shanxi Formation tight sandstones in the northern Ordos Basin (China). Results show that pore types of the Shanxi tight sandstone reservoirs include intergranular pores, dissolution pores, intercrystalline micropores, and microfracture, while the throats are dominated by sheet-like and tube-shaped throats. The HPMI-derived pore-throat size ranges from 0.006 to 10 μm, and the pore-throats with a radius larger than 10 μm were less frequent. The pore body size obtained from CPMI shows similar characteristics with radii ranging from 100 to 525 μm, while the throat size varies greatly with radii ranging from 0.5 to 11.5 µm, resulting in a wide range of pore-throat radius ratio. The full range of pore size distribution curves obtained from the combination of HPMI and CPMI displays multimodal with radii ranging from 0.006 to 525 µm. Permeability of the tight sandstone reservoirs is primarily controlled by relatively larger pore throats with small proportions, and the permeability decreases as the proportions of smaller pore-throats increase. The pervading nanopores in the tight gas sandstone reservoirs contribute little to the permeability but play an important role in the reservoir storage capacity. A new empirical equation obtained by multiple regression indicates that r15 (pore-throat size corresponding to 15% mercury saturation) is the best permeability estimator for tight gas sandstone reservoirs, which yields the highest correlation coefficient of 0.9629 with permeability and porosity.
Factors Influencing the Positive Aspects of Caregiving in Family Caregivers of People with Dementia: A Mixed-Methods Systematic Review Protocol
Authors: CHEN Liuliu , ZHONG Mengqi , ZHAO Junyan , Yang Liu , ZHU Nanxi , ZHANG Jianghui , ZHANG Hongtao , Lin Hui , Li Muyao , Li Zhenwen , DENG Renli 
Published: January 2024

Abstract

Aim: To provide an overview of the various influencing factors related to the positive
aspects of caring for dementia patients by family caregivers.
Design: Mixed-methods systematic review.
Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guided this protocol as reported. Peer-reviewed studies published in English from 1997 to the present will be searched via information sources, gray literature, and the following databases: Web of Science, PsycINFO, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. Eligible trials will also be retrieved from ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform. For the mixed-method studies, which will include both qualitative and quantitative studies, the Mixed Method Appraisal Tool will be used. The Newcastle-Ottawa Scale for case-control and cohort studies, as well as critical appraisal tools for cross-sectional and quantitative studies from the Joanna Briggs Institute (JBI), will be consulted to assess the methodological quality of the studies, and the data will be extricated with JBI data extraction tools. The narrative form of the findings will be presented in the absence of textual pooling.
Discussion: This systematic review will synthesize and analyze the factors that influence the positive aspects of caring for dementia patients by family caregivers.
Conclusion: The findings will help decision-makers to adopt more appropriate and effective interventions for caregivers of people with dementia.
Patient or public contributions: This protocol study will ascertain the factors affecting the mediation of and path to improved caregiving, explore the factors’ action mechanisms, and examine the controlling factors to design a more targeted intervention program to improve caregiving, thus improving dementia patients’ outcomes and care. Contributions of the findings will include evidence of strategies that address ongoing dementia caregiving issuesand the identification of areas for future research.
Facilitators and Barriers to Vaccination Uptake in Pregnancy: A Qualitative Systematic Review
Authors: Razai Mohammad S , Mansour Rania , Ravindran Kavi , Freeman Samuel , Mason-Apps Charlotte , Morris Joan , Majeed Azeem , Ussher Michael , Hargreaves Sally , Oakeshott Pippa 
Published: January 2024

Abstract

Introduction
Vaccination during pregnancy protects both the mother and the foetus from vaccine-preventable diseases. However, uptake of the recommended vaccines (influenza, pertussis, COVID-19) by pregnant women remains low in Europe and the USA. Understanding the reasons for this is crucial to inform strategies to increase vaccination rates in pregnant women. This qualitative systematic review aimed to identify the barriers and facilitators to vaccination against influenza, pertussis/whooping cough and COVID-19 during pregnancy and identify possible strategies to increase vaccination rates.
Methods
We conducted a comprehensive search of electronic databases, including Medline, PsycINFO, CINAHL, Web of Science, WHO database, Embase and grey literature to identify qualitative studies that explored barriers and facilitators to vaccine uptake among pregnant women (PROSPERO CRD42023399488). The search was limited to studies published between 2012 and 2022 conducted in high-income countries with established vaccination programmes during pregnancy. Studies were thematically analysed and underwent quality assessment using the Joanna Briggs Institute validated critical appraisal tool for qualitative research.
Results
Out of 2681 articles screened, 28 studies (n=1573 participants) were eligible for inclusion. Five overarching themes emerged relating to personal, provider and systemic factors. Barriers to vaccine uptake included concerns about vaccine safety and efficacy, lack of knowledge about vaccines’ benefits and necessity, fear of adverse effects on the foetus or mother and low perception of disease severity. Facilitators included recommendations from trusted healthcare providers, easy access to vaccination, clear communication on the benefits and safety of vaccination, and positive social influences from family and friends. Strategies for increasing vaccination uptake included strong and proactive vaccine recommendations by trusted healthcare professionals, provision of vaccines during routine antenatal care, and clear and consistent communication about vaccines addressing pregnant women’s concerns.
Conclusion
This review highlights the need for interventions that address the identified barriers to vaccine uptake among pregnant women. Recommendation from a healthcare provider can play a significant role in promoting vaccine uptake, as can clear risk/benefit communication and convenient access to vaccination. Addressing concerns about vaccine safety and providing accurate information about vaccines is also important.
Leveraging Artificial Intelligence for Enhanced Project Completion in Education
Authors: SWARGIARY KHRITISH 
Published: January 2024

Abstract
This research investigates the integration of Artificial Intelligence (AI) in educational settings, specifically its impact on project-based learning. In a controlled environment, 200 students participated, evaluating the effects of an AI-driven project completion support system on time management, engagement, and academic performance. Significant improvements were observed in the Experimental Group, emphasizing the positive influence of AI on educational project completion and its potential to enhance overall academic success. Sampling involved 200 students from Mumbai, India, randomly assigned to control (n = 100) and experimental (n = 100) groups using unbiased random sampling techniques, ensuring generalizability. Data collection employed pre/post-project surveys, project completion rates, and academic metrics, capturing insights into students' habits before and after AI support system implementation. Led by EdTech Research Association faculty and co-author Kavita Roy, the study showcased marked improvements in time management, engagement, and academic performance in the Experimental Group. The AI-driven system emerged as an effective guide, aiding students in time management and positively influencing engagement and academic performance. Acknowledging study limitations guides future research. Implications advocate for strategic AI integration in education, urging institutions and policymakers to responsibly adopt AI tools. Positive outcomes highlight the need for preparing students for the digital age. Future research should explore long-term effects, diversity considerations, ethics, and teacher training programs, providing a comprehensive understanding of AI's role in education. In summary, the findings underscore AI's positive impact on project completion, signaling a path to a more efficient learning environment and contributing significantly to students' overall academic success in the evolving educational technology landscape.
PCME and PCO Rates After Combined Phaco-Trabeculectomy vs. Phaco Alone
Authors: Achiron Asaf , Levinger Eliya , Ostrovsky Michael , Friehmann Asaf , Elhaddad Omar , Tole Derek , Darcy Kieren , Leadbetter Duncan , Tuuminen Raimo , Goldberg Mordechai 
Published: January 2024

Abstract
Background: To assess the risk for pseudophakic cystoid macular edema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.
Methods: Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis. Multivariate Cox regression controlling for age and gender was used to estimate the hazard ratio (HR) for neodymium-doped yttrium aluminium garnet (Nd:YAG) laser capsulotomies.
Results: This study included 56,973 cataract surgeries without and 288 with concomitant trabeculectomy (phaco-trab) with a mean follow-up time of 6.9 ± 4.2 years.
Baseline variables (age and gender, diabetes, pseudoexfoliation, use of pupil expansion device, and postoperative follow-up time) were comparable between the groups. Postoperative rates of PCME remained non-significant between the cataract surgery and phaco-trabe groups both in uni- and multivariate analysis (OR 0.347, 95%CI 0.049-2.477, p=0.291). Furthermore, in Cox regression analysis adjusted for the patients' age and gender, Nd:YAG laser capsulotomy rates remained non-significant between the cataract surgery and phaco-trabe groups(HR 1.250, 95%CI 0.883-1.769, p=0.209).
Conclusions: In our large cohort study, combining trabeculectomy with cataract surgery did not predispose to an increased risk of major postoperative complications.
Extreme fast charging of lithium metal batteries enabled by a molten-salt-derived nanocrystal interphase
Authors: Yang Chunlei , Wu Wei , Niu Fang , Sun Chuankui , Wang Qingrong , Wang Man , Wang Jun , Deng Yonghong , Ning De , Wu Liyun , Li Wenjie , Zhang Jie , Chen Ming , Cheng Huiming 
Published: January 2024

Abstract
The extreme fast charging performance of lithium metal batteries (LMBs) with a long life is an important focus in the development of next-generation battery technologies. The friable solid electrolyte interphase and dendritic lithium growth are major problems. We report the formation of an inorganic nanocrystal-dominant interphase produced by pre-immersing the Li in molten lithium bis(fluorosulfonyl)imide that suppresses the overgrowth of the usual interphase. Its high surface modulus combined with fast Li+ diffusivity enables a reversible dendrite-proof deposition under ultrahigh-rate conditions. It gives a record-breaking cumulative plating/stripping capacity of >240,000 mAh cm−2 at 30 mA cm−2@30 mAh cm−2 for a symmetric cell and an extreme fast charging performance at 6 C for 500 cycles for a Li||LiCoO2 full cell with a high-areal-capacity, thus expanding the use of LMBs to high-loading and power-intensive scenarios. Its usability both in roll-to-roll production and in different electrolytes indicates its scalable and industrial potential.
Work Ability and Return-To-Work of Patients with Post-COVID-19: A Systematic Review and Meta-Analysis
Authors: Ottiger Marcel , Poppele Iris , Sperling Naveen , Schlesinger Torsten , Müller Katrin 
Published: January 2024

Abstract

Background: In addition to several sequelae of post-COVID-19, individuals also experience significant limitations in work ability, resulting in negative consequences for the return-to-work (RTW) process. This systematic review and meta-analysis were conducted to assess the impact of post-COVID-19 on work ability and RTW of individuals previously infected with SARS-CoV-2.
Methods: Studies on the work ability and RTW of patients with post-COVID-19 (more than 12 weeks after an acute SARS-CoV-2 infection) were regarded eligible for inclusion. Systematic search of literature was performed up to March 2023 using five databases (MEDLINE, EMBASE, CINAHL, CENTRAL and WHO COVID 19). Study selection followed the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) Statement. A meta-analysis estimated the overall success rate of RTW. The risk of bias of the included studies was evaluated with the Newcastle Ottawa Scale (NOS).
Results: 19 relevant studies, published between 2021 and 2023, were included in the systematic review, involving 21.155 patients from 14 different countries. The findings indicate that a significant proportion of individuals with post-COVID-19 experience persistent symptoms and functional impairments, with fatigue being the most prominent symptom. These persistent symptoms can have a considerable (negative) impact on individuals' physical and psychological capacity to participate in work-related activities, leading to lower work ability and increased absenteeism. The RTW for post-COVID-19 patients is complex, with approximately 60.9% of patients successfully returning to work after 12 or more weeks following SARS-CoV-2 infection. Among those who successfully returning to work, a considerable number need modifications in their work duties or hours to cope with residual impairments. Factors such as workplace accommodations, supportive policies, and occupational rehabilitation programs play a crucial role in facilitating successful RTW.
Conclusions:The systematic review underscores the substantial impact of post-COVID-19 on work-related outcomes. The implications of this research highlight the need for healthcare providers, employers, and policymakers to collaborate in creating inclusive work environments and implementing tailored rehabilitation programs to support individuals recovering from post-COVID-19. Further research should focus on long-term follow-up studies with mixed methods to gain a more comprehensive understanding of the long-term consequences of post-COVID-19 on work ability and RTW outcomes.
PROSPERO registration number: CRD42023385436
Minimally invasive determination of PDAC subtype and therapy-induced subtype switch by means of circulating cell-free RNA
Authors: Lueong Smiths , Metzenmacher Martin , Trajkovic-Arsic Marija , Cheung Phyllis F. Y. , Reißig Timm M. , von Neuhoff Nils , Grainne O'Kane , Gallinger Steven , Ramotar Stephanie , Dodd Anna , Knox Jennifer J , Muckenhuber Alexander , Kunzmann Volker , Horn Peter A. , Hoheisel Jörg D. , Siveke Jens Thomas 
Published: January 2024

Abstract

Background Pancreatic ductal adenocarcinoma (PDAC) comprises two clinically relevant subtypes. Currently, determining the tumor subtype relies on tissue biopsies. Unfortunately, these biopsies are spatially biased, highly invasive, difficult to obtain, and unsuitable for monitoring tumor dynamics. Methods We employed whole transcriptome sequencing (WTS) on circulating cell-free (cf) RNA in plasma samples from patients with well-characterized tumor subtypes. Additionally, quantitative protein mass spectrometry was utilized to identify minimally invasive markers for tumor subtypes. We validated our findings using independent liquid and tissue samples from large clinical trials and investigated treatment-induced subtype dynamics and responses. Results An exploratory analysis of 10 patients (four basal-like and six classical) was conducted using whole transcriptome sequencing (WTS). Following differential transcript abundance analysis and integration with expression data from tumor and non-tumor samples (N > 200), we identified 32 protein-coding subtype-specific cfRNA-defined transcripts. The subtype specificity of these transcripts was validated in two independent tissue cohorts comprising 195 and 250 cases, respectively. Three disease-relevant cfRNA-defined subtype markers (DEGS1, KDELC1, andRPL23AP7) consistently associated with basal-like tumors across all cohorts and were validated using machine learning. Further analysis of these markers using RT-ddPCR in over 160 patient sera and 24 samples from healthy donors revealed their predictive and prognostic value, as well as subtype specificity and therapy-induced dynamics. In both tumor and liquid biopsies, the overexpression of these markers was associated with poor overall and progression-free survival. Moreover, elevated tissue/liquid levels of the identified markers were linked to a poor response to systemic therapy and rapid disease recurrence in resected patients. Conclusion Our data provide support for the clinical significance of cfRNA markers in determining tumor subtypes and monitoring disease recurrence and therapy-induced subtype switches in pancreatic ductal adenocarcinoma (PDAC). Consequently, further validation studies in larger independent cohorts are warranted to confirm the robustness and generalizability of these findings.
Predictors of Neonatal Hyperbilirubinemia's Outcome and Their Relationships to the Etiology.
Authors: Ali Basma Abdelmoez , Mahmoud Eman Abdelmaged , Shehata Nageh Mohamed 
Published: January 2024

Abstract
Background
Neonatal jaundice (NJ) accounts for 13.5% of all neonatal care unit admission, making it the third common cause of admission for neonates. Although jaundice is a benign condition, newborn should be assessed in order to prevent further progression into severe hyperbilirubinemia and acute encephalopathy. So, we aimed in this study to assess neonatal hyperbilirubinemia etiologies, outcomes, and the predictors of these outcomes in Minia Governorate, Egypt.
Methods
It was a prospective study included one hundred sixty nine neonates with clinical jaundice who were admitted in Neonatal Intensive Care Unit in Minia university children hospital during the period from August 2022 to May 2023. They randomly selected and were subjected to; a structured questioner, clinical examination and laboratory investigations. They were followed up to detect their outcomes (survival, mortality or discharged with complications.
Results
most common cause is exaggerated physiological jaundice (40.8%) followed by ABO incompatibility (25.4%), RH incompatibility (16.6%), sepsis (8.9%) and G6PD deficiency (%8.3).Neonates with exaggerated physiological jaundice were statistically significant recovered more than those with other causes. Neonates with sepsis had poor outcome. Bilirubin level at admission was a significant predictor for the good outcome (survival) of neonatal hyperbilirubinemia.
Conclusion
Weight, prematurity, history of previous jaundiced baby, breast feeding, bilirubin level at admission and CRP were significantly related to the outcome of jaundice.
Bioprospecting and Repurposing of Leaf Biomass to Support Sustainable Biopharmacy: Evaluation of seasonal chemical variations and biological activities of six Eucalyptus essential oils
Authors: Migacz Izabel Pietczak , Wang Mei , Faoro Janaine Alberto Marangoni , Santos Sidney Mariano dos , Formagio Anelise Samara Nazari , Kassuya Candida Aparecida Leite , Rehman Junaid Ur , Perera Wilmer Hervet , Gonçalves Vitória Caroline , Chaves Douglas Siqueira de Almeida , Raman Vijayasankar , Farago Paulo Vitor , Khan Ikhlas Ahmed , Manfron Jane 
Published: January 2024

Abstract

This study focuses on six Eucalyptus species, namely E. badjensis, E. benthamii, E. dunnii, E. grandis, E. globulus, and E. saligna aiming at a sustainable use of their green biomass. These species were grown at the same location and stage of development. Leaf essential oils were extracted by hydrodistillation using a Clevenger apparatus during the four seasons. GC-MS and HPTLC techniques were used to analyze the chemical composition. E. badjensis displayed a consistent composition, with 1,8-cineole being the predominant component. Notably, the proportion of 1,8-cineole in E. badjensis was 77,35% in spring, 69,46% in summer, 95,30% in autumn, and 89,30% in winter. E. globulus also exhibited 1,8-cineole as its primary constituent, with proportions fluctuating slightly across seasons at 84,87%, 79,94%, 81%, and 85,88%, respectively. The proportions and constituents of various species differed significantly. HPTLC was successfully used as a swift technique to monitor the chemical composition of essential oils (EOs) in various Eucalyptus species during the seasonality. GC/MS and HPTLC analysis showed that different Eucalyptus species displayed unique chemical compositions, while both the chemical profile and productivity of all analyzed EOs were affected by seasonality. This finding was demonstrated in the principal components cluster. The analysis of six species has revealed that the EO of E. benthamii is the most potent in thwarting the infestation of Cimex lectularius. Additionally, all six EOs demonstrated antioxidant activity in the ABTS model. EOs of E. benthamii, E. dunnii, and E. grandis showed significant anti-inflammatory activities in experimental models.
Starvation Effects on Superworms: Implications in Identifying Plastic-Degrading Genes and Microbes
Authors: Kim Hong Rae , Suh Dong-Eun , Lee Sukkyoo , Choi Donggeon 
Published: January 2024

Abstract

To address the challenge of plastic waste, plastic-degrading insects have been gaining considerable attention as promising solutions. This study revealed that subjecting superworms to starvation triggers a stress response, altering both the transcriptome and microbiome. Stress responses have been observed in insects even when they ingest plastics; hence, incorporating starved insects as a control group can augment the precision of selecting genes and microorganisms implicated in plastic degradation. We used Starved and Bran-fed groups as controls and identified 42 genes and five bacteria that exhibited a common increase in superworms consuming polyethylene. This approach has the potential to improve the accuracy of identifying the genetic and microbial factors linked to plastic biodegradation.