bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation
Authors: Wang Jin-bao , Ding Shi-lin , Liu Xiao-song , Yu Tianren , Wu Zeng-an , Li Yu-xiang 
Published: November 2023

Background:
Colorectal cancer (CRC) is a malignant tumor. Slug has been
found to display a key role in diversified cancers, but its relevant regulatory
mechanisms in CRC development are not fully explored.

Objective:
Hence, exploring the function and regulatory mechanisms of Slug is critical
for the treatment of CRC.

Methods:
Protein expressions of Slug, N-cadherin, E-cadherin, Snail, HIF-1α, SUMO-
1, Drp1, Opa1, Mfn1/2, PGC-1α, NRF1, and TFAM were measured through western
blot. To evaluate the protein expression of Slug and SUMO-1, an immunofluorescence
assay was used. Cell migration ability was tested through transwell assay. The
SUMOylation of Slug was examined through CO-IP assay.

Results:
Slug displayed higher expression and facilitated tumor metastasis in CRC. In
addition, hypoxia treatment was discovered to upregulate HIF-1α, Slug, and SUMO-1
levels, as well as induce Slug SUMOylation. Slug SUMOylation markedly affected
mitochondrial biosynthesis, fusion, and mitogen-related protein expression levels to
trigger mitochondrial stress. Additionally, the induced mitochondrial stress by hypoxia
could be rescued by Slug inhibition and TAK-981 treatment.

Conclusion:
Our study expounded that hypoxia affects mitochondrial stress and
facilitates tumor metastasis of CRC through Slug SUMOylation.
Polymer Nanocomposites: A Review on Recent Advances in the Field of
Green Polymer Nanocomposites
Authors: Saha Anushree 
Published: November 2023

Abstract:
In order to address environmental issues, polymer nanocomposites are becoming
more and more popular because of their remarkable functionality. Their use in various fields is
highlighted by their special physicochemical features (i.e., stability, high reactivity, robustness,
regenerability, etc.), conductivity, electronic compatibility, quick interfacial contacts, simplicity
of functionalization, simplicity of synthesis, interface-to-volume ratio, and low cost. Green polymer nanocomposites have drawn a lot of attention for use in a variety of applications to preserve the environment. Because they are made of eco-friendly materials, they are frequently
utilised in the automobile, building, packaging, and medical industries. Eco-friendly solutions to
the problems caused by plastic trash are biodegradable polymers produced from renewable
sources (microbes, plants, and animals). Plant fibres and natural resins are combined to create
green composite materials. These fibres and resins used in green composites can be broken down
by bacteria. The mixing of natural fillers and organic polymers results in green polymer nanocomposites with distinct characteristics. This review is anticipated to be comprehensive, compelling, and practical for the scientists and business professionals who collaborate to address a variety of environmental problems on a global scale using green polymer nanocomposites.
Conventional Versus Microwave Induced Synthesis and Biological
Evolution of Coumarin Substituted Thioaryl Pyrazolyl Pyrazoline
Authors: Shaikh Parin V. , Brahmbhatt Dinkar I. 
Published: November 2023

Aim:
This is a comparative study of some new coumarin substituted thioaryl pyrazolyl pyrazoline.

Methods:
The target compounds were synthesized using both conventional as well as microwave irradiation by reaction of coumarin chalcones with different substituted hydrazine hydrates and aryl hydrazines to give the resultant pyrazoline derivatives. Microwave reaction, enhanced or-ganic reactions, and reduced reaction time led to better yields and selectivity than conventional methods.

Results:
The obtained compounds were characterized by different spectroscopic analysis includ-ing IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental-analysis and evaluated for their antimicrobial screening against a representative panel of bacteria (Bacillus subtilis, Staphylococ-cus aureus, Escherichia coli, Salmonella typhi) and fungi (Aspergillus niger, Candida albicans).

Conclusion:
In the present study, we have synthesized coumarin pyrazoline derivatives clubbed with benzofuran pyrazole via both conventional and microwave irradiation and also subjected to antibacterial and antifungal studies. Synthesis of target compounds by the microwave irradiation enhanced reaction rate and reduced reaction time led to better yields and selectivity than conven-tional methods. The study of antibacterial and antifungal activities revealed that all the com-pounds exhibited reasonable to excellent activities against the pathogenic strains.
Design and Analysis of L-shape Defect-based 2D Photonic Crystal Waveguide for Optical Interconnect Application With Signal Amplification
Authors: Panda Abinash , Mishra Chandra Sekhar , Pukhrambam Puspa Devi , Daher Malek 
Published: November 2023

Photonic crystal (PhC) has witnessed an unprecedented research interest since its discovery by Yablonovitch and John in 1987. PhC has undergone substantial theoretical and experimental study because of its periodic dielectric structure and ability to guide and manipulate light at the optical wavelength scale. The photonic band gap (PBG), one of the fundamental characteristics of PhC, prohibits the transmission of light inside a definite wavelength range. The PBG property of PhC opens up enormous opportunities for envisioning a wide range of applications like communication, filtering, bio-sensing, interconnector, modulator, polarizer, environmental safety, food processing etc. However, a peculiar property can be observed when defects are added to PhC, the periodicity of this dielectric structure is disrupted, allowing PC to exhibit high electromagnetic field confinement, a little more volume, and feeble confinement loss. The propagation of light can be altered and engineered by altering the structural characteristics of PhC or introducing appropriate materials into the rods of PC. Among the different applications, optical interconnect is the most escalating application in a photonic integrated circuit. This chapter addresses a novel 2D photonic crystal waveguide for optical amplifier application. The proposed structure comprises 9×9 circular rods of Si with air in the background. A sequence of Si rods is removed to create a defect in the 90o shape. The finite difference time domain method (FDTD) can be adjusted to envisage the electric field allocation along the 90o bend defective region.Several geometrical factors, such as the radius of the Si rods and the gap between lattices, are judiciously optimized in order to realize strong light confinement inside the defect region. The intensity of incident light and the transmitted light is evaluated through numerical analysis, where it is found that the transmitted intensity from the waveguide is much higher than the intensity of incident light, which ensures that the projected construction can act as an optical amplifier. Apart from this, the bending loss close to the bending area of the photonic waveguide is investigated. A small bending loss of the order of 10-5 exists, which indicates efficient guidance of light along the 90o bend path. Lastly, the confinement loss along the defect region is studied, which is found to be in the order of 10-11. So, the light propagation with negligible loss indicates that the future PCW could be an appropriate applicant for optical interconnect applications.
Exploring the Use of a Learning-Based Exergame to Enhance Physical Literacy, Soft Skills, and Academic Learning in School-Age Children: Pilot Interventional Study
Authors: Goncalves Aurelie , Lespiau Florence , Briet Gaëtan , Vaillant-Coindard Eugénie , Palermo Angèle , Decobert Elsa , Allegret-Bourdon Nathan , Charbonnier Elodie 
Published: November 2023

Background
There is ample evidence that most children do not perform enough physical activity (PA). To address this major public health problem, the French government implemented 30 minutes of daily PA (DPA) at schools but did not provide any supplemental resources or concrete guidance. Considering both children’s interest in video games and the need for teachers to complete their curriculum, the use of a learning-based exergame that combines PA and learning appears particularly relevant.

Objective
The first objective of this study was to evaluate the feasibility of implementing 30 minutes of DPA through exergaming among school-age children. The second objective was to examine the effects of an exergaming program on physical literacy, academic learning, and soft skills (motivation, self-efficacy, and concentration).

Methods
This interventional study had a pre-post design and used the Play LÜ exergame platform. The study included 79 children with a mean age of 8.9 (SD 1.2) years from grade 2 (7 years old) to grade 5 (11 years old). Play LÜ requires players to throw balls against a wall to reach a target or to activate an object and provides an interactive game area for educational activities linked to specific learning themes. After a 4-session familiarization phase during which the teachers chose to prioritize mathematics learning in 30-minute DPA sessions, students took part in DPA sessions over a period of 3 weeks with Play LÜ and a motor skills circuit behind the LÜ setup to keep them continuously active. All sessions were carried out by PA specialists. Each session started with a warm-up using the Grööve application, continued with main activities promoting mathematics learning adapted to each grade level, and ended with a 3-minute meditation for returning to a calm and serene state using the Gaïa application. Before (T0) and after (T1) the program, students completed a self-evaluation booklet to assess their levels of physical literacy, academic performance, and soft skills.

Results
The implementation of this exergaming program was welcomed by the school’s administration, teaching staff, and parents. After the program, we observed increased scores for physical literacy (difference +2.6, percentage change +3.6%; W=933.0; P=.002; rrb=−0.39, 95% CI −0.58 to −0.16) and motivation in mathematics (+0.7, +9.8%; W=381.5; P=.005; rrb=−0.44, 95% CI −0.66 to −0.16). In addition, it is important to note that some measures progressed differently across learning levels and age groups.

Conclusions
The study results indicate positive impacts of learning-based exergaming on physical literacy and motivation in mathematics among school-age children.
The Allergenicity Potential of Edible Freshwater Fish
Authors: Atika Hanum Falihah  , Muhammad Novrizal Abdi Sahid  , Ika Puspitasari  
Published: November 2023

A Freshwater fish is a popular type of fish consumed in Indonesia besides seawater fish. However, until now the most available information regarding the potential allergenicity of fish is only related to seawater fish. The potential allergenicity of freshwater fish has not been studied much, so it has not been identified and characterized. Based on this, this review aims to collect information regarding the potential allergenicity of protein in freshwater fish and the effect of processing on this potential. The potential allergenicity of proteins in several freshwater fish has been confirmed by immunoblotting and ELISA, namely mujair, nile, catfish, mas, toman, janjan, tambakan, tiger scat, barramundi, and eel. The identified allergenic proteins include parvalbumin, tropomyosin, enolase, aldolase, creatine kinase, triosephosphate isomerase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase. In addition, several proteins in other freshwater fish also have allergenicity potential but have not been confirmed through research, namely pomfret, gourami, snakehead, catfish, eel, betutu, and cetol. The potential allergenicity of fish protein is also influenced by the processing process. Changes in the potential allergenicity are related to the characteristics of each allergen protein. Therefore, it is necessary to select the appropriate processing so that potential allergenicity can be suppressed.
EFEKTIVITAS PENGEMBANGAN MODUL BIMBINGAN KLASIKAL UNTUK KESADARAN DIRI PESERTA DIDIK KELAS VIII SMP FK BINA MUDA
Authors: Aulia Vita , Fatimah Siti , Manuardi Ardian Renata 
Published: November 2023

Development of modules as a medium of innovation in guidance and counseling activities, especially in classical guidance services. This module is used as teaching material for service materials that are focused on the context of learners' self-awareness. This research uses an R&D method developed by Borg and Gall which was adapted to stage seven. The purpose of this study is to produce a product that has been tested by several experts such as material experts, media experts, and practitioner experts. The research subjects consisted of 39 students at SMP FK Bina Muda who were specially selected to measure product feasibility through modules. Based on the product testing results that have been obtained from several experts and the response of students, this module has an average percentage of 9 1.63% according to the criteria that this product is very feasible to use for the Junior High School level. Meanwhile, the results of the t-test analysis on the pretest and posttest result data were obtained by sig. (2-tailed) by 0.000. Thus, the results of the research on the effectiveness of this analysis showed that there was a positive change between the use of modules and the self-awareness of class VIII students at SMP FK Bina Muda.
Pendampingan Membaca dan Menulis Aksara Jawa di Madrasah Baitus Solihin Kajor Wetan Selopamioro Imogiri Bantul
Authors: Suwardiyono Dian Nugroho 
Published: November 2023

Kajor Wetan Village is an area that has a lot of Javanese art. There is a lot of cultural art here that continues to be preserved. One of the most basic things in culture is language. Java has its own unique script or letters, namely the Javanese script. Currently, many children are reluctant to learn about Javanese script. This is due to a lack of interest in learning Javanese script, this is of course a problem. Baitus Solihin Madrasah is the only madrasah in Kajor Wetan village. This madrasah is a gathering place for children in Kajor Wetan village. The assistance activity for reading and writing Javanese script aims to provide madrasah students with an understanding of local culture to strengthen religious teaching values and add cultural values in Kajor Wetan. This mentoring activity is divided into 3 parts over 2 days. The first day contains an explanation of the basics of Javanese script and practice reading Javanese script. The second day was filled with learning games and competitions in reading Javanese characters. In general, this mentoring activity has provided additional knowledge to madrasah students regarding Javanese script and has been able to add value to Kajor Wetan village as an arts village.
Key Word: Local culture, Javanese Alphabet, Reading and Writing, Cultural Vilage
PENGARUH KOMPETENSI PETUGAS DAN DISIPLIN KERJA TERHADAP KUALITAS PELAYANAN INSEMINASI BUATAN (IB) PADA SAPI DI KECAMATAN WAY SEPUTIH KABUPATEN LAMPUNG TENGAH
Authors: Solikin Solikin , Suharto Suharto , Mazni Afdal 
Published: November 2023

Di Kecamatan Way Seputih Kabupaten Lampung Tengah telah ada petugas Inseminasi Buatan (IB), namun karena jumlahnya yang terbatas dan pendidikan yang dimiliki juga tidak berlatar belang pendidikan peternakan, maka sering memberikan pelayanan Inseminasi Buatan (IB) pada sapi yang menyebabkan sapi setelah dilakukan Inseminasi Buatan (IB) gagal bunting. Selain itu karena tempat domisili petugas yang berjauhan dengan pembagian tempat kerja dan belum adanya posko pengaduan Inseminasi Buatan (IB) pada sapi, menyebabkan petani peternak sapi terlambat melaporkan masa birahi sapi, sehingga harus menunggu masa birahi kembali baru dilakukan Inseminasi Buatan (IB). Selain itu kurang disiplinya petugas Inseminasi Buatan (IB) untuk segera memberikan pelayanan Inseminasi Buatan (IB) juga menjadi faktor kegagalan dalam Inseminasi Buatan (IB). Permasalahan lain yang muncul adalah petugas tidak dapat dihubungi nomor Hand Phone (HP)-nya saat ada sapi yang sedang birahi mengakibatkan birahi sapi terlewati sehingga petani peternak masih harus menunggu 21 hari lagi untuk mendapatkan masa birahi sapi.
Populasi sebanyak 155 petani peternak sapi dengan sampel yang digunakan sebanyak 34 responden. Pengambilan data ini dengan mengunakan quisioner sebagai alat bantu penelitian. Hasil analisis yang diperoleh ada pengaruh kompetensi petugas terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng. Dari hasil uji F diketahui ada pengaruh kompetensi petugas dan disiplin kerja terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng. Koefisien nilai R menunjukan keeratan pengaruh antara kompetensi petugas dan disiplin kerja terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng tergolong kategori sedang.
Impact of Carbon Nanotubes on the Mechanical and Electrical Properties of Silicone
Authors: Sałaciński Michał , Dydek Kamil , Leski Andrzej , Kozera Rafał , Mucha Mateusz , Karczmarz Wojciech 
Published: November 2023

Abstract
This paper presents the results of a structure study of a dispersion composite on a silicone matrix with a filler in the form of multi-walled carbon nanotubes (MWCNTs). The study aims to determine the effect of the filler on the composite mechanical properties and electrical conductivity. Materials that are electrically conductive and exhibit high mechanical properties can find applications in high-strain sensors. During the study, the characteristic properties of the susceptible materials, silicone alone and silicone with different filler contents (4%, 6%, and 8% by weight), were determined after curing. Microscopic observations were performed to assess the influence of carbon fillers on the material structure and to determine the level of homogeneity of the material. Examination of mechanical properties facilitated the determination of the Shor A hardness (ShA), stiffness, and Poisson’s ratio of the cured composites, depending on the nanotubes’ content. In parallel with the study of mechanical properties, the effect of loading, and the associated deformation of the samples, on the conductivity of the composite was investigated. Based on the results obtained, a discussion was carried out on the type of conductivity characteristic of silicone with different filler content as well as depending on the level of deformation of the samples.
PERAN BIAS PERILAKU DALAM MEMEDIASI PENGARUH LITERASI KEUANGAN DAN FAKTOR SOSIODEMOGRAFI TERHADAP KEPUTUSAN INVESTASI SAHAM
Authors: Jayati Nyoman Devi Novita Sri , Wiksuana I Gst. Bgs. , Jatra I Made 
Published: November 2023

Investment is an economic activity that involves investing directly or indirectly, so that owners of capital have the opportunity to benefit from secured capital in the future. The research was conducted to determine the role that behavioral bias has in mediating the factors of stock investment decision making. The population used in this study were all stock investors in Denpasar City, with a total sample of 100 respondents based on a purposive sampling technique. SEM PLS is an analysis technique used in this study using the SmartPLS 4.0 application. Based on the analysis above, the results show that financial literacy, sociodemographic factors, and behavioral biases have a significant positive effect on stock investment decisions. Financial literacy and sociodemographic factors can influence investor behavior bias. Meanwhile, the effect of financial literacy and sociodemographic factors on investment decisions cannot be influenced by behavioral biases indirectly. From this study, it appears that in making stock investment decisions, Denpasar City investors have considered financial literacy, sociodemographic factors, and behavioral biases in order to avoid investment risks.
Keywords: Behavioral Bias; Financial Literacy; Sociodemographic Factors; Investment Decsion.
PENGARUH HARGA SEWA, FASILITAS DAN LOKASI TERHADAP NIAT MENYEWA KEMBALI PADA JASA RUMAH KOS DI DESA JIMBARAN
Authors: Markandhya I Wayan Lostha , Jatra I Made 
Published: November 2023

This study aims to determine the effect of rental prices, facilities and locations on the intention to rent back on boarding house services in Jimbaran Village and the effect of rental prices, facilities, and locations simultaneously and the most dominant variable on the intention to rent back on boarding house services in Jimbaran Village. The respondents were 100 people who were still actively studying and renting boarding houses in Jimbaran Village in the last 3 years when this study was conducted. This study used non-probability sampling method, especially purposive sampling. Data analysis using multiple linear regression. The results of the analysis of this study are, rental prices have a positive and significant effect on the intention to rent back on boarding house services, facilities have a positive and significant effect on the intention to rent back on boarding house services, location has a positive and significant effect on the intention to rent back on boarding house services, rental prices, facilities and location simultaneously affect the intention to rent back on boarding house services and rental prices are the most dominant variables in this study. This research becomes reference material for boarding house owners in Jimbaran Village to continue to maintain their marketing by reviewing rental prices, facilities and locations according to the expectations of consumers who want to look for boarding houses in Jimbaran Village with the hope of being able to influence consumers to rent again.
Keywords: Renetal Price; Facilities; Location; Repurchase intention
ORGANIZATIONAL CITIZENSHIP BEHAVIOR: PERAN BUDAYA ORGANISASI, KEPUASAN KERJA, DAN KOMITMEN ORGANISASIONAL
Authors: Kurniawan Ignatius Soni , Hina Dendhy Umbu 
Published: November 2023

This study aims to examine the influence of organizational culture, job satisfaction, and organizational commitment on OCB. Research data collection methods using a questionnaire. This study uses a population of all employees of Dinas Pendidikan Kepemudaan dan Olahraga Kabupaten Sumba. Data was taken using a questionnaire from 55 respondents by census. Hypothesis testing is done using multiple linear regression analyses. The results showed that organizational culture had a significant positive effect on OCB, job satisfaction had a significant positive effect on OCB, and organizational commitment had a significant positive effect on OCB. The research implication states that improving antecedents will encourage improvements in OCB.
Keywords: Organizational Culture; Job Satisfaction; Organizational Commitment; Organizational Citizenship Behavior