bluuebunny/crossref_metadata_2025_split huggingface dataset:
Puberty Is Delayed in Male Growth Hormone Receptor Gene—Disrupted Mice
Authors: KEENE DAVID E. , SUESCUN MARIA O. , BOSTWICK MELISSA G. , CHANDRASHEKAR VARADARAJ , BARTKE ANDRZEJ , KOPCHICK JOHN J. 
Published: November 2023

ABSTRACTThe role of insulin‐like growth factor‐I (IGF‐I) in the initiation of puberty and testicular function is poorly understood. Growth hormone (GH) receptor (R) gene‐disrupted mice or GHR gene “knockouts” (GHR‐KO) are GH resistant and IGF‐I deficient. To assess whether the age of sexual maturation is affected by the absence of IGF‐I, various parameters of sexual development including testicular and accessory reproductive organ weights, balanopreputial separation, germ cell development, and intratesticular testosterone levels were determined in normal and GHR‐KO mice between the ages of 25 and 60 days. In addition, at 36 days of age, the testosterone response to luteinizing hormone (LH) treatment was assessed in these mice. The results indicate that the balanopreputial separation was delayed 5 days, and a significant increase in the weights of the seminal vesicles (SV) occurred later in GHR‐KO mice than in normal animals (between 30 and 35 days and between 35 and 40 days, respectively). Also, the weights of testes and epididymii were significantly reduced in GHR‐KO mice. The intratesticular testosterone levels and the testosterone response to LH treatment were attenuated in GHR gene‐disrupted mice. Furthermore, elongated spermatids appeared later in the testes of GHR‐KO mice than in the testes of normal mice. These results suggest that the absence of IGF‐I secretion delays the normal course of sexual maturation in male GHR‐KO mice, indicating that IGF‐I plays an important role in the initiation of puberty in male mice.
Interpenetrating alginate network as drug delivery matrix: Effects on protein stability and release
Authors: Monteiro Ana P. F. , Pérez‐Jiménez Aurora , Spitzlei Claire , Caucheteux Joachim , Alves Vitor Delgado , Lambert Stéphanie , Grandfils Christian 
Published: November 2023

AbstractThe study investigates the rheological properties and protein release capacity of a uniform hydrogel composed of sodium alginate (SA) and poloxamer (P407). The hydrogel is prepared through the sustained release of calcium ions, resulting in a reinforced and homogeneous interpenetrating networks (IPNs) of SA and P407 polymeric chains. By adjusting the amount of crosslink agent, the hydrogel exhibites an adjustable dissolution ratio and adaptable gelling time. Moreover, the composite showed a well‐structured network and superior mechanical strength, enabling the sustained release of both calcium ions and Soybean Trypsin Inhibitor (STI) protein, a model of Bone Morphogenic Protein (BMP). Importantly, the protein release kinetic can be tuned based on the SA content in the polymeric blend, highlighting the versatile nature of this hydrogel for drug delivery purposes.
Inhibition of autophagy enhances the anticancer effect of Schisandrin B on head and neck squamous cell carcinoma
Authors: Li Mengmeng , Tang Qinglai , Li Shisheng , Yang Xinming , Zhang Ying , Tang Xiaojun , Huang Peiying , Yin Danhui 
Published: November 2023

AbstractHead and neck squamous cell carcinoma (HNSCC) is among the most common malignant tumors worldwide and has a poor prognosis. Autophagy regulation has been proposed as a possible treatment option for HNSCC. Schisandrin B (Sch B) exerts anticancer effects by regulating apoptosis and autophagy, but the anticancer effect of Sch B in HNSCC remains unclear. This study aimed to investigate the effects of Sch B on human Cal27 HNSCC cells and to further reveal its potential regulatory mechanisms. The anticancer effect of Sch B was evaluated in vitro by flow cytometry, clonogenic assays, and Western blot analysis. The regulatory mechanism of Sch B‐induced apoptosis and autophagy was further explored by polymerase chain reaction, luciferase assay, and reactive oxygen species (ROS) detection. The results showed that Sch B significantly induced apoptosis and autophagy in Cal27 cells and that inhibition of autophagy enhanced the apoptotic effect of Sch B on Cal27 cells. Additionally, Sch B‐activated autophagy in Cal27 cells was dependent on the nuclear factor‐kappa B (NF‐κB) pathway, and ROS acted as a regulator of the NF‐B pathway. N‐acetylcysteine, a scavenger of ROS, inhibited Sch B‐dependent autophagy via the NF‐κB pathway. Based on the results, Sch B is a potential therapeutic agent for HNSCC and activates the NF‐κB pathway by increasing ROS production, which subsequently promotes autophagy in HNSCC cells. Therefore, the strategy of enhancing the anticancer effect of Sch B by inhibiting autophagy deserves further attention.
Quality and educational content of Douyin and TikTok short videos on early screening of rectal cancer
Authors: Li Lian‐Shuo , Luo Xiao‐Juan , Shu Xin‐Peng , Li Zi‐Wei , Liu Fei , Liu Xu‐Rui , Tong Yue , Lv Quan , Liu Xiao‐Yu , Zhang Wei , Peng Dong 
Published: November 2023

AbstractBackground and AimThe aim of this study was to assess the quality and content of videos on Douyin and TikTok for their educational role on early screening of rectal cancer (RC).MethodsWe conducted a search for videos related to RC on the Douyin and TikTok applications on 20 April 2023. The search was conducted in Chinese on Douyin and in English and Japanese on TikTok. A sample of the first 100 videos recommended by the software was selected for each language group. The content of the videos was evaluated using a content scorecard, while the quality of the videos was assessed using DISCERN. Subsequently, we conducted two partial correlations: one between the DISCERN score and the number of likes, and another between the video content score and the number of likes.ResultsThis study encompassed a total of 89 Chinese, 54 English, and 51 Japanese videos. After selection, 78 Chinese, 38 English, and 25 Japanese videos were identified to contain content related to early screening for RC, prompting further quality assessment. Notably, videos in the Chinese language showed the highest DISCERN score (P < 0.05). In terms of partial correlation analysis, it was observed that both the content score and DISCERN score did not show a significant correlation with the number of likes (P > 0.05).ConclusionIn terms of quality score and content score, the Chinese videos on Douyin show superiority over the English and Japanese videos on TikTok. However, there is potential for improving the overall appeal of the Chinese videos.
A Reliability Generalization Meta‐Analysis of the Kaufman Domains of Creativity Scale
Authors: Sen Sedat , Yörük Süreyya 
Published: November 2023

ABSTRACTThe Kaufman Domains of Creativity Scale (K‐DOCS) is a self‐reported rating scale that measures creative behaviors in five areas. Despite the vast amount of research on the scale, the internal consistency reliability of K‐DOCS scores have not been examined. Specifically, there is no study on the overall reliability coefficients, the variation in the reliability of scores, and reliability induction. In the present study, reliability generalization meta‐analyses were conducted to address these issues. The sample consisted of 56 studies that produced 60 Cronbach's alpha coefficients in total. The pooled alpha values were estimated to be .904 (total scale), .825 (Self/Everyday subscale), .858 (Scholarly subscale), .887 (Performance subscale), .867 (Scientific subscale), and .861 (Artistic subscale). The moderator analyses showed that the reliability estimates of K‐DOCS total scores and Self/Everyday subscale scores did not differ with respect to any of the moderator variables. On the other hand, certain variables affected the alpha coefficients for Scholarly (educational level, SD of the age, and mean age), Performance (continent, educational level, ethnicity, Caucasian percentage, SD of the age, and mean age), Scientific (language, test version, continent, country, ethnicity, SD of the age, and mean age), and Artistic (continent, language, country, mean age, and total mean score) subscale scores. Finally, the reliability induction rate was 39.62%, and there were no statistically significant differences between the inducing and reporting studies with respect to the continuous variables (mean of the total score, means and SDs of the sample age, and percentages of female and Caucasian). Our findings indicate that the K‐DOCS provides highly reliable scores. However, certain variables contribute to systematic errors in Scholarly, Performance, Scientific, and Artistic subscale scores. Hence, scores on these subscales should be interpreted with caution. Due to a high amount of variation in the reliability coefficients, reliability induction is not advised for the K‐DOCS.
Investigation the nutritional properties of Auricularia auricula pulp fermented with Lactobacillus strains and their effects on gut microbiota
Authors: Li Hongcai , Tan Pei , Lei Wenzhi , Yang Siqi , Fan Lingjia , Yang Taihao , Guo Chunfeng , Gao Zhenpeng 
Published: November 2023

AbstractBACKGROUNDAuricularia auricula is rich in bioactive components, and microbial fermentation can further dramatically increase its content and bioavailability. However, there are few studies on the relationship between fermented A. auricula pulp (FAAP) and gut microbiota. In this study, standard strains Lactobacillus plantarum 21801 and 21805 purchased from the China Center of Industrial Culture Collection were used to ferment A. auricula pulp at a ratio of 2:1, with an inoculum of 5%, a fermentation temperature of 31 °C, and a fermentation time of 22 h. The nutritional properties, aroma, and color of FAAP and their effects on the body characteristics of mice and the structure and abundance of gut microbiota are discussed.RESULTSThe results showed that, compared with A. auricula pulp, FAAP significantly increased the nutritional properties while maintaining favorable sensory quality and flavor profiles. Among them, the content of total polyphenols and total flavonoids reached 22.04 μg mL−1 and 20.56 μg mL−1 respectively, and the 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid free‐radical scavenging rate increased to 73.21%. The consumption of FAAP had no negative effects on weight or liver and kidney function in mice and dramatically enhanced the antioxidant capacity in the liver and serum. The production of short‐chain fatty acids in the gut was promoted, the relative abundance of beneficial bacteria (Lactobacillus, Bifidobacterium, norank_f__Muribaculaceae and unclassified_f__Lachnospiraceae) increased, and the growth of some pathogenic bacteria (Helicobacter, Mucispirillum, and Alloprevotella) was inhibited.CONCLUSIONThese findings demonstrate that FAAP is rich in nutrients and has unique functional properties that promote host health and regulate the gut microbiota. © 2023 Society of Chemical Industry.
Using Norwegian National Patient Registry data to understand associations between potentially traumatic life experiences and mental health care use in adolescence
Authors: Skandsen Annika , Hysing Mari , Askeland Kristin Gärtner , Teicher Martin H. , Sand Liv , Bøe Tormod 
Published: November 2023

AbstractExposure to potentially traumatic experiences (PTEs) is common among children and adolescents and associated with an increased risk of psychiatric diagnoses. This study aimed to ascertain how the number of PTEs differed across adolescent psychiatric diagnoses. Data on PTE exposure were derived from the youth@hordaland survey, and Axis 1 data were from the linked Norwegian National Patient Registry (NPR). Among 10,257 total adolescents, 9,555 (age range: 16–19 years, 53.9% female) consented to register linkage, 8,845 of whom were included in the analyses. Having contact with Child and Adolescent Mental Health Services (CAMHS) predicted more PTEs (estimated marginal mean [EMM] = 1.04, SE = 0.05) and exposure to two or more PTEs compared to having no CAMHS contact (EMM = 0.60) after adjusting for age, ethnicity, sex, and parental education. Adolescents diagnosed with attention‐deficit/hyperactivity disorder, depression, trauma‐related disorders, conduct disorder, and anxiety experienced significantly more PTEs (EMMs = 0.90–1.63) than those with no CAMHS contact (EMM = 0.57, SE = 0.01). All diagnostic categories except psychosis, autism spectrum disorders, and eating disorders had a significantly higher rate of PTEs compared with adolescents with no CAMHS contact. The study highlights the potential role of exposure to multiple PTEs as a transdiagnostic risk factor, although the level of risk varies between diagnoses.
Methods to mitigate human–wildlife conflicts involving common mesopredators: a meta‐analysis
Authors: Lazure Louis , Weladji Robert B. 
Published: November 2023

AbstractConflicts between humans and mesopredators are frequent and widespread. Over the last decades, conflicts have led to the development and application of different mitigation methods to diminish the costs and damage caused by such conflicts. We conducted a systematic literature search and meta‐analysis to assess the influence of different mitigation methods on 3 common nuisance species: raccoons (Procyon lotor), red foxes (Vulpes vulpes), and striped skunks (Mephitis mephitis). A majority of the studies, from 1963‒2022, were conducted in North America, followed by Australia and Europe. The predation of wildlife species of conservation concern by nuisance species is the main reported source of conflict in the published literature. Lethal control is the most commonly tested method and is generally effective at reducing conflicts based on the calculated effect size. Barriers have mixed effects, with electric fences and nest exclosures both being effective, whereas conventional fences seem to be less effective. Repellents mimicking predators (e.g., guard animal, predator smell) are also effective. Conditioned taste aversion is a promising approach, but no precise product or chemical has proven to be effective. Many interventions suffered from a lack of validation through experimental approach. Research on human–mesopredator conflict mitigation would benefit from repeated studies using the same methods in similar contexts, thus reducing heterogeneity in the results, and by testing new and innovative methods.
Chip‐Based Microwave Photonic Payload Repeater for High Throughput Satellites
Authors: Liang Dong , Mohammad Ahmad W. , Roeloffzen Chris , Tan Qinggui , Li Li , Li Xiaojun , Shao Bin , Zhang Bo , Deng Xiangke , Zheng Feiteng , Wevers Lennart , Grootjans Robert , Kapteijn Paul , Timens Roelof Bernardus , Heuvink Rick , Musa Sami 
Published: November 2023

AbstractHigh‐throughput satellite (HTS) is an ideal way to realize cross‐regional massive, multifaceted digital exchange services, and it requires a signal processing module that can be massively multiplexed and has high flexibility. Due to the limitations of the frequency characteristics, microwave integrated circuits are difficult to meet this requirement. One solution to this problem is photonic integrated circuits (PICs). However, full‐size PIC satellite payloads containing main optoelectronic components are extremely challenging to implement on monolithic or hybrid integrated platforms. Here, the study demonstrates a hybrid integrated on‐chip microwave‐photonic satellite repeater with large‐scale multiplexing potential and high flexibility. This is a demonstration of a hybrid integration of a InP/Si3N4 external cavity laser, arrayed InP modulators, and semiconductor optical amplifiers (SOAs), as well as multifunctional Si3N4 signal processors, to fulfill a 1 × 4 Ka‐band repeater module with on‐chip arrayed frequency down‐conversion and outstanding narrowband photonic channelization. When combined with the full‐chip photonic RF repeater, broadband, highly integrated, and cost‐effective communications satellite payloads will become realizable more quickly in the near future.
Robust Super‐Resolution Image Transmission Based on a Ring Core Fiber with Orbital Angular Momentum
Authors: Wu Zheyu , Gao Ran , Zhou Sitong , Wang Fei , Li Zhipei , Chang Huan , Guo Dong , Xin Xiangjun , Zhang Qi , Tian Feng , Wu Qiang 
Published: November 2023

AbstractSingle‐fiber imaging technology offers unique insights for research and inspection in difficult‐to‐reach and narrow spaces. In particular, ultra‐compact multimode fiber (MMF) imaging, has received increasing interest over the past decade. However, MMF imaging will be seriously distorted when subjected to dynamic perturbations due to time‐varying mode coupling, and the imaging of space objects via Gaussian beam will be relatively degraded at the edge due to insufficient contrast. Here, a robust super‐resolution image transmission method based on a ring core fiber (RCF) with orbital angular momentum (OAM) is proposed and experimentally demonstrated. The OAM modes propagating in the RCF form a series of weakly coupled mode groups, making the imaging system robust to external perturbations. In addition, a spiral phase plate is used as a vortex filter to produce OAM for edge enhancement, thus improving the image resolution. Furthermore, a few‐shot U‐Transformer neural network is proposed to enhance the resilience of the developed RCF‐OAM imaging system against environmental perturbations. Finally, the developed RCF‐OAM imaging system achieves biological image transmission, demonstrating the practicality of the scheme. This pioneering RCF OAM image transmission system may have broad applications, potentially revolutionizing fields such as biological imaging and industrial non‐destructive testing.
Hot‐Electron Driven Ultrafast Optical Polarization Conversion with Graphene‐Loaded Metasurface
Authors: Xu Leijun , He Jiale , Tang Weiwei , Yang Chengsen , Han Li , Zhang Libo , Zhu He , Liu Shijie , Liu Changlong , Qiu Min , Li Guanhai , Chen Xiaoshuang 
Published: November 2023

AbstractThe switching speed of light polarization plays a crucial role in determining the upper‐limit bandwidth of applications like optical communications and laser microscopy. However, conventional polarization elements based on macroscopic anisotropic crystals like birefringent crystals and chalcogenide glasses are either static or restricted by the low switching time of about hundreds of picoseconds. Here, a femtosecond‐scale all‐optical polarization controlling method is proposed through engineering the excited hot electrons in a graphene‐loaded metasurface. Remarkably, a giant polarization orientation from left‐handed polarization (LCP) to right‐handed polarization (RCP) in the Poincaré sphere (≈80° rotation) is realized within only 200 fs in the mid‐infrared. With pumping, the dedicated polarization‐sensitive design allows the metasurface to exhibit a consistent resonance blueshift as the transient increase of the hot‐electron temperature in graphene for y‐polarized incidence. This polarization conversion approach features a giant modulation range and enables the reflected light to be dynamically and arbitrarily modulated into RCP, LCP, and linear states at femtosecond timescale. A few logic operations “AND”, “OR”, “NAND”, and “XOR” based on this method are also demonstrated by monitoring the normalized Stokes parameters. It is believed that this work may find practical application in next‐generation signal‐processing systems with large capacity.
Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B‐Induced Photoaging In Vitro and In Vivo
Authors: Wu Yumeng , Geng Lihua , Zhang Jingjing , Wu Ning , Yang Yue , Zhang Quanbin , Duan Delin , Wang Jing 
Published: November 2023

AbstractSeaweed polysaccharides can be used for protective skin photoaging which is caused by long‐term exposure to ultraviolet B (UVB). In this study, a multifunctional composite hydrogel (FACP5) is prepared using sulfated galactofucan polysaccharides, alginate oligosaccharides as active ingredients, and polyacrylonitrile modified κ‐Carrageenan as substrate. The properties of FACP5 show that it has good water retention, spreadability, and adhesion. The antiphotoaging activity is evaluated in vitro and in vivo. In vitro experiments demonstrate that the components of FACP5 exhibit good biocompatibility, antioxidant, and anti‐tyrosinase activities, and could reduce the cell death rate induced by UVB. In vivo experiments demonstrate that, compared with the mice skin in model group, the skin water content treated with FACP5 increases by 29.80%; the thicknesses of epidermis and dermis decrease by 53.56% and 43.98%, respectively; the activities of catalase and superoxide dismutase increase by 1.59 and 0.72 times, respectively; the contents of interleukin‐6 and tumor necrosis factor‐α decrease by 19.21% and 17.85%, respectively; hydroxyproline content increases by 32.42%; the expression level of matrix metalloproteinase‐3 downregulates by 42.80%. These results indicate that FACP5 has skin barrier repairing, antioxidant, anti‐inflammatory, and inhibiting collagen degradation activies, FACP5 can be used as a skin protection remedy for photoaging.
YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2
Authors: Wu Anhao , Wang Xi , Zhang Fang , Yang Xin , Quan Yuhang , Dong Junyu , Lai Yafang , Yang Dechun , Sun Jian , Wang Maohua 
Published: November 2023

AbstractTriple‐negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer, and chemoresistance is the major determinant of TNBC treatment failure. This study explores the molecular mechanism of TNBC chemoresistance. The Cancer Genome Atlas, breast cancer integrative platform, and GEPIA databases were used to analyze the expression and correlation of YTHDF1 and seven in absentia homology 2 (SIAH2) in breast cancer. Knockdown of YTHDF1 and SIAH2, or overexpression of SIAH2 in vitro and in vivo, was conducted to evaluate the impact of changes in YTHDF1 and SIAH2 expression on TNBC cell proliferation, apoptosis, stemness, drug resistance, and Hippo pathway gene expression. YTHDF1 and SIAH2 were highly expressed in breast cancer patients and TNBC cells. Knockdown of YTHDF1 and SIAH2 significantly inhibited proliferation and stemness and promoted apoptosis and chemosensitivity of TNBC cells. Mechanistically, the knockdown of YTHDF1 inhibited the expression of SIAH2, thereby downregulating the Hippo pathway, which inhibited proliferation and stemness and promoted apoptosis and chemosensitivity of TNBC cells. The current findings revealed the regulatory mechanism of YTHDF1 in TNBC and clarified the role of the YTHDF1/SIAH2 axis in TNBC drug resistance and stemness. This could provide new insights into the vital role of targeting YTHDF1/SIAH2 to suppress drug resistance and stemness in TNBC cells.