bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing the effectiveness of digital cognitive behavioural therapy for chronic insomnia in clinical practice
Authors: Shi Yuan , Ren Rong , Zhang Ye , Vitiello Michael V. , Tang Xiangdong 
Published: October 2023

SummaryDigital cognitive behavioural therapy for chronic insomnia (D‐CBT‐I) has been shown to be as efficacious as traditional CBT‐I. However, not all patients achieve insomnia remission after treatment. We explored the factors influencing the effectiveness of D‐CBT‐I in a clinical practice. A total of 414 Asian chronic insomniacs were studied during a 6 week D‐CBT‐I intervention. All patients were assessed at baseline and posttreatment and were determined to be remitters or non‐remitters, responders or non‐responders by posttreatment criteria; Insomnia Severity Index (ISI <8) or ISI reduction ≥8, to examine whether remission and response status were associated with patient baseline characteristics. The average baseline ISI score in all subjects was 16.29 points. At posttreatment, 192 (46.4%) patients achieved ISI remission and 218 (52.7%) patients demonstrated an ISI response. An increased baseline early morning awakening time and ISI score were independently associated with a lower odds for remission (OR, 0.995 and 0.991, respectively). Increased baseline Patients Health Questionnaire‐9 score was independently associated with higher odds for response (OR, 1.114). Our results suggest that D‐CBT‐I can be recommended as the first‐line treatment for chronic insomnia, particularly in insomniacs with milder insomnia symptoms and more severe depressive symptoms. Meanwhile, the effectiveness of D‐CBT‐I was adversely affected by longer early morning awakening time and higher insomnia severity at pretreatment, which may be improved by more intense intervention and greater therapeutic support or by traditional CBT‐I.
Safety of TCMCB07, a melanocortin‐4 antagonist peptide, in dogs with naturally occurring cachexia
Authors: Axiak‐Bechtel Sandra M. , Leach Stacey B. , Newton‐Northup Jessica R. , Milner Rowan J. , Fox‐Alvarez Stacey A. , Fagman Lana I. , Young Kaylee A. , Tate Deborah J. , Wright Zachary M. , Chretin John D. , Allen Justin W. , Yoshimoto Sean K. , Selting Kimberly A. , Flesner Brian K. , White Carrie R. , Mills Tracy , Aherne Michael , Bergman Philip J. , Qi LeAnn , Gruber Kenneth A. , Callahan Michael F. 
Published: October 2023

AbstractBackgroundThe melanocortin 4 antagonist TCMCB07 is safe and effective in reversing cachexia caused by sepsis or cancer in rodents. The safety and pharmacokinetics of TCMCB07 are demonstrated in healthy beagle dogs.Hypothesis/ObjectivesThe objectives of this study were to investigate the safety, peak plasma concentrations, and potential for efficacy of TCMCB07 in pet dogs with naturally occurring cachexia over a 4‐week time period.AnimalsFourteen dogs with cachexia of any underlying cause, except cancer of the oral cavity or gastrointestinal tract, were eligible for enrollment with informed client consent.MethodsThis study was a prospective, 1‐armed open‐label trial. Physical examination, complete blood count, chemistry panel, and owner‐assessed quality of life surveys were checked at weeks 1, 2, and 4. Due to potential for bradycardia and hypotension, Holter monitoring and blood pressure evaluations were scheduled at pre‐enrollment and week 4.ResultsFourteen dogs completed the trial. Significant changes detected included increased mean body weight (18.6‐19.5 kg, P < .02), increased body condition score (median Tufts 5‐point thin dog scale score P < .004 and WSAVA muscle condition score P < .02) and increased mean blood urea nitrogen (21.79‐30.43 mg dL−1, P < .004). On quality of life surveys, pet owners perceived their dog appeared to be panting less (P < .002) and that the general health improved (P < .03). Four dogs had a change in coat pigmentation. The peak plasma concentration of TCMCB07 in cachectic dogs was similar to that in healthy beagle dogs.Conclusions and Clinical ImportanceTCMCB07 was safe and has potential efficacy in pet dogs with cachexia.
Pharmacokinetics of meloxicam in pre‐ruminant calves after intravenous, oral, and subcutaneous administration
Authors: Jokela Annemari , Nyrhilä Alexandra , Adam Magdy , Salla Kati , Raekallio Marja , Aho Riikka , Norring Marianna , Hokkanen Ann‐Helena 
Published: October 2023

AbstractMeloxicam is routinely used for pain alleviation in pre‐ruminant calves during husbandry procedures. The pharmacokinetics of a single dose (0.5 mg/kg) of meloxicam was investigated after intravenous (IV), subcutaneous (SC), and oral (PO) administration in 30 pre‐ruminant calves. Each group included 10 calves. Oral meloxicam was administered at least 1 h after feeding. Plasma samples were collected for up to 168 h, and the meloxicam concentration was analysed with liquid chromatography and mass spectrometry, followed by a noncompartmental pharmacokinetic analysis. The maximum meloxicam concentrations in plasma were 1.91 ± 0.27 μg/mL and 1.77 ± 0.16 μg/mL after SC and PO routes, respectively. The time of maximum concentration was 7.6 ± 2.8 h after SC and 10.0 ± 5.7 h after PO administration. The approximate bioavailability of meloxicam was 97% for SC and PO routes. The elimination half‐lives were 79.2 ± 12.4, 84.6 ± 24.8, and 84.8 ± 22.3 h after IV, SC, and PO routes, respectively. The results suggest that the therapeutic meloxicam concentrations in plasma that are required for pain relief in other species, such as horses, may be maintained for several days following a single dose (0.5 mg/kg) administered IV, SC, or PO in calves.
Self‐training approach for crack detection using synthesized crack images based on conditional generative adversarial network
Authors: Shim Seungbo 
Published: October 2023

AbstractUrban infrastructure plays a crucial role in determining the quality of life for citizens. However, given the increasing number of aging infrastructures, regular inspections are essential to prevent accidents. Deep learning studies have been conducted to detect structural damage and ensure high accuracy and reliability of these inspections. However, these detection algorithms often face challenges due to scarcity of damage data. To overcome this issue, this paper proposes a method for synthesizing crack images and utilizing them for crack detection. Initially, crack images are synthesized from labeled images by using a conditional generative adversarial network. Subsequently, a new self‐training method is implemented wherein the synthesized crack images from the prediction images were incorporated into the learning process to enhance data diversity. The proposed approach yields promising results with a mean intersection over union of 80.34% and F1‐score of 76.31% on average. The proposed method can aid further research on virtual image generation for crack detection, seeking to reduce the reliance on extensive image collection.
Histoplasma antigen detection in unconfirmed pulmonary tuberculosis and cross‐reactivity with Aspergillus antigen in patients and in food in Jakarta, Indonesia
Authors: Wijaya Meiliyana , Surja Sem Samuel , Adawiyah Robiatul , Hariadi Ariananda , Setianingrum Findra , Rozaliyani Anna , Burhan Erlina , Tugiran Mulyati , Sjam Ridhawati , Denning David W. , Wahyuningsih Retno 
Published: October 2023

AbstractPurposeH. capsulatum is endemic in Indonesia, but the value of Histoplasma antigen detection has not been studied.Patients and MethodsHistoplasma galactomannan (GM) ELISA was applied to sera of patients with unproven pulmonary tuberculosis (TB) and patients with a positive Aspergillus GM. Both Histoplasma and Aspergillus GM tests were performed to determine any possible cross‐reaction with certain foods.ResultsFourteen of 122 (11.5%) sera of patients with newly diagnosed clinical TB were positive for Histoplasma GM. The positivity rate in the serum of patients 5–6 and 12 months after TB diagnosis was 3.8% and 3.5%, respectively. Of 88 positive Aspergillus GM sera, 63 (71.6%) were also positive for Histoplasma GM. All tested foods were positive for Aspergillus GM, while 65% of foods were positive for Histoplasma GM.ConclusionGalactomannan is widespread in sera and food in Jakarta, possibly related to food consumption. Histoplasma and Aspergillus antigen detection for the diagnosis will require additional means of confirming the diagnosis; negative tests may be more helpful for ruling out invasive histoplasmosis and aspergillosis.
REVEILLE2 thermosensitive splicing: a molecular basis for the integration of nocturnal temperature information by the Arabidopsis circadian clock
Authors: James Allan B. , Sharples Chantal , Laird Janet , Armstrong Emily May , Guo Wenbin , Tzioutziou Nikoleta , Zhang Runxuan , Brown John W. S. , Nimmo Hugh G. , Jones Matthew A. 
Published: October 2023

Summary
Cold stress is one of the major environmental factors that limit growth and yield of plants. However, it is still not fully understood how plants account for daily temperature fluctuations, nor how these temperature changes are integrated with other regulatory systems such as the circadian clock.
We demonstrate that REVEILLE2 undergoes alternative splicing after chilling that increases accumulation of a transcript isoform encoding a MYB‐like transcription factor. We explore the biological function of REVEILLE2 in Arabidopsis thaliana using a combination of molecular genetics, transcriptomics, and physiology.
Disruption of REVEILLE2 alternative splicing alters regulatory gene expression, impairs circadian timing, and improves photosynthetic capacity. Changes in nuclear gene expression are particularly apparent in the initial hours following chilling, with chloroplast gene expression subsequently upregulated.
The response of REVEILLE2 to chilling extends our understanding of plants immediate response to cooling. We propose that the circadian component REVEILLE2 restricts plants responses to nocturnal reductions in temperature, thereby enabling appropriate responses to daily environmental changes.
Expression of advanced glycation end products and their receptors in diabetic periodontitis patients
Authors: Thomas Julie Toby , Joseph Betsy , Sorsa Timo , Mauramo Matti , Anil Sukumaran , Waltimo Tuomas 
Published: October 2023

AbstractAimThe systematic review aimed to compare the levels of advanced glycation end products (AGEs) and RAGE (AGE receptors) expression in diabetic periodontitis patients with non‐diabetic periodontitis patients and to identify the relationship of AGE and RAGE levels with periodontal disease severity.Materials and MethodsThe literature search was carried out according to PRISMA guidelines by two independent researchers using four online databases: PubMed, Scopus, Web of Science Core Collection, and Pro‐Quest. Relevant studies published between 2000 and March 2023 were included in this review. The association of diabetes and AGE/RAGE levels on periodontal health, periodontal pocket depth (PPD), and clinical attachment loss (CAL) was studied.ResultsSixteen cross‐sectional studies, including 2794 patients (age range 15–75 years), were identified in the final stage. An elevated AGE level was observed among patients with diabetes and chronic periodontal disease compared to the non‐diabetic group. Furthermore, the levels of AGE and RAGE are associated with CAL and PPD. Potential confounding factors like genetic and methodological differences were also responsible for AGE and RAGE variation.ConclusionLevels of AGEs and RAGE expressions in diabetic periodontitis patients differ from non‐diabetic periodontitis patients. The differences may impact the course and severity of periodontal disease.
Experiences of health and social professionals using care technologies with older adults during the COVID‐19 pandemic: A qualitative study
Authors: MARTÍN‐PALOMO María Teresa , GONZÁLEZ‐CALO Inés , Lucchetti Giancarlo , Badanta Bárbara 
Published: October 2023

AbstractObjectiveTo investigate the perceptions and experiences of health and social care professionals concerning the use of technology for the care of older adults during the COVID‐19 pandemic.Design and measuresA phenomenological qualitative, exploratory, and descriptive design using semi‐structured interviews.SampleTwenty Spanish health and social care workers in six Spanish cities between February and July 2021, during the COVID‐19 pandemic.ResultsDuring the COVID‐19 pandemic care workers have become more familiar with technology devices, but they also recognize certain barriers for the implementation of technology, mainly in nursing homes and homecare, related to concerns of lack of humanization and difficulties in accessing and using these devices.ConclusionPoliticians and social and healthcare managers should be aware of the benefits of techno‐care, reducing the difficulties in implementing it and making more funding and further training available to care providers.
The effects of long‐pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single‐arm clinical trial
Authors: Park Sujin , Jang Hyunwoo , Seong Seol Hwa , Kim Ji Young , Lee Eun Jung , Bae Yu Jeong , Ahn Yong Ju , Kim Jihee , Oh Sang Ho 
Published: October 2023

AbstractBackgroundRosacea is a chronic skin disorder characterised by abnormal neurovasculature and inflammation in the central region of the face. The efficacy of pulsed‐dye laser and intense pulsed light treatments for rosacea have been demonstrated in several clinical trials. However, there is currently no research on the efficacy of long‐pulsed alexandrite laser (LPAL) therapy alone for rosacea‐related facial redness and its effect on skin microbiota.AimTo evaluate the efficacy of LPAL therapy on facial redness in rosacea and assess changes in skin microbiota composition.MethodsSubjects with rosacea (n = 21, mean age: 39.2 ± 11.3 years) were recruited from two medical institutions and received monthly LPAL treatments (Clarity II™, Lutronic Corp.) for 3 months. At each visit, clinical photographs were taken, and erythema was measured using a spectrometer. At the initial and final visits, the Dermatology Life Quality Index (DLQI) and Skin Sensitivity Questionnaire (SSQ) were evaluated. Skin swabs were obtained at the initial and final visit, and facial microbiome composition was analysed using 16S rRNA amplicon sequencing.ResultsAfter three LPAL treatment sessions, the average facial erythema index, measured using Mexameter® decreased significantly from 360.0 ± 96.7 at baseline to 312.0 ± 94.5 at the final visit (p < .05). The DLQI and SSQ showed significant improvement of symptoms. Skin microbiome diversity and relative abundance were altered significantly, particularly in the genera Clostridium, Lawsonella, Bacteroides, and Lactobacillus.ConclusionsLPAL therapy alone showed favourable efficacy for the treatment of facial redness in rosacea, with some impacts on the skin microbiota composition.
Going Dutch? Firm exports and FDI in the wake of the 2014 EU‐Russia sanctions
Authors: Kohl Tristan , van den Berg Marcel , Franssen Loe 
Published: October 2023

AbstractWe examine the 2014 European Union economic sanctions on exports to Russia and the Russian retaliatory measures on imports from several Western countries. Using the universe of highly disaggregated international trade and taxation data for firms in the Netherlands, we systematically analyze the impact of these economic sanctions on Dutch firms' exports and foreign direct investment. Our analyses account for the product‐specific EU restrictions on arms, equipment used for oil exploration and extraction, and dual‐use products suitable for civilian and military use, as well as the Russian import ban on various primary commodities. Our empirical findings highlight the overall negative impact of sanctions on the intensive margin of exports. However, having a foreign affiliate in Russia helps to mitigate the otherwise negative impact of sanctions on the extensive margin of exports. We also show that exporters do not circumvent sanctions by setting up a local affiliate in Russia. In fact, exposure to Russian countersanctions may even force firms to close their Russian affiliates.
A critical feminist system justification analysis of climate obstructionism on the part of conservative white men
Authors: Dakin Nicolette M. , Azevedo Flávio , Jost John T. 
Published: October 2023

AbstractIn the U.S. and other Western nations, one demographic group is most likely to downplay anthropogenic climate change and its consequences, to embrace the “discourse of delay,” and to resist pro‐environmental policies: conservative white men. In this article, we bring together critical, feminist perspectives on masculinity and environmental dominance and social psychological insights from system justification theory to hypothesize that identity‐protective cognition, material interests, and ideological legitimation processes combine and reinforce one another to motivate obstructionism when it comes to taking climate action. Our hope is that by integrating critical and empirical approaches to social science—and illuminating individual and group psychological factors that are embedded in specific historical and political settings—it will be possible to increase solidarity among environmental scholars and activists and forge a shared vision of climate justice across disciplines.
Herbicide resistance in Alopecurus myosuroides: The value of routine testing of seed samples submitted by farmers since 1985
Authors: Cook Sarah K. , Tatnell Lynn V. , Moss Stephen , Hull Richard , Garthwaite David , Dyer Chris 
Published: October 2023

AbstractIn 35 years of routine screening for herbicide resistance, a total of 3758 seed sample/herbicide combinations were assayed. Resistance testing was done in either pots in glasshouses (chlortoluron, fenoxaprop and mesosulfuron‐methyl + iodosulfuron‐methyl sodium) or Petri‐dishes in incubators (sethoxydim, cycloxydim and pendimethalin). With all herbicides, the relationship between herbicide efficacy and year of sampling was linear, with the slope representing the annual loss of efficacy. This was higher for the ALS inhibitors mesosulfuron + iodosulfuron (3.73% year−1) and ACCase inhibitors sethoxydim/cycloxydim (1.92% year−1) and fenoxaprop (1.36% year−1) than for the substituted urea chlorotoluron (0.69% year−1) and the dinitroaniline pendimethalin (1.10% year−1). These results are consistent with other studies on the relative resistance risk associated with these different modes of action. There was also a surprisingly good correlation between results for random and non‐random resistance testing, which has also been found in studies with other weed species in Canada and Australia. This indicates that routine testing of submitted samples can replace, at least partly, the need for random surveys which tend to be both labour intensive and expensive. These results, compiled over 35 years, show the value of routine resistance screening, not only for detecting resistance at the individual field level (‘micro’ scale), but also the distribution, evolution and impact of resistance country‐wide (‘macro’ scale). However, it is important that standardised testing methods, including appropriate reference populations, are used by different testing centres to ensure consistent results.
The effect of nurse‐led telephone‐based interventions on glycosylated hemoglobin levels in people with type 2 diabetes: A meta‐analysis
Authors: Yuksel Merve , Celik Ferya , Bektas Hicran 
Published: October 2023

AbstractBackgroundTelenursing interventions can contribute to achieving optimal glycemic control.AimThis meta‐analysis aimed to determine the effect of nurse‐led telephone‐based interventions on glycosylated hemoglobin (HbA1c) levels in people with type 2 diabetes.MethodsWe searched electronic databases for studies published in English up to January 2023. This study was conducted in accordance with the PRISMA 2020 checklist. The intervention effects were pooled using a random‐effects model. Two authors independently assessed the risk of bias using the Cochrane Collaboration tool.ResultsEight studies involving 1179 people with type 2 diabetes were included in this study. Interventions were performed for 15–30 min and 5–16 calls. There was no evidence of a significant publication bias. The evaluation of meta‐analysis data showed that nurse‐led telephone‐based interventions significantly reduced HbA1c levels in people with type 2 diabetes (mean difference = −0.53, 95% Confidence Interval [−0.89, −0.17], p = .003).Linking Evidence to ActionNurse‐led telephone‐based interventions focused on reducing glycosylated hemoglobin levels in people with type 2 diabetes can be used as an effective intervention to achieve glycemic control. We recommend holding an average of 15–25 min interviews once or twice a week.
Guarana (Paullinia cupana) but Not Low-Dose Caffeine Improves Cycling Time-Trial Performance Versus Placebo
Authors: Penna Eduardo M. , Harp Alec , Hack Brian , Talik Tyler N. , Millard-Stafford Melinda 
Published: October 2023

Guarana (GUA) seed extract, containing caffeine (CAF) and additional bioactive compounds, may positively affect mental performance, but evidence regarding exercise is limited. This investigation assessed acute GUA ingestion compared with CAF on endurance performance. Eleven endurance-trained noncyclists and cyclists ( = 49.7 ± 5.9, 60.4 ± 4.6 ml·kg·min−1) completed a double-blind, crossover experiment after ingesting (a) 100 mg CAF, (b) 500 mg GUA (containing 130 mg CAF), or (c) placebo (P) prior to 60-min fixed cycling workload (FIX) + 15-min time trial. Oxygen uptake, heart rate, respiratory exchange ratio, blood glucose, and lactate were not different (p ≥ .052) during FIX. A significant interaction (p = .042) for perceived exertion was observed at 50-min FIX with lower rating (p = .023) for GUA versus CAF but not compared with P. Work accumulated over 15-min time trial was greater (p = .038) for GUA versus P due to higher early (1–11 min) work outputs. Work performance favored (effect size = 0.18; 95% confidence interval [0.003, 0.355], p = .046) GUA (241.4 ± 39.9 kJ) versus P (232.1 ± 46.6 kJ), but CAF (232.3 ± 43.9) was not different from GUA (effect size = 0.19; 95% confidence interval [−0.022, 0.410], p = .079) or P. Postexercise strength loss was not attenuated with GUA (−5.6 ± 8.5%) or CAF (−8.3 ± 9.4%) versus P (−10.3 ± 5.1%). Acute GUA ingestion improved work performance relative to P, but effects were trivial to small and unrelated to altered substrate oxidation or muscular strength. Ergogenicity may involve central mechanisms reducing perceived effort with GUA (containing 130 mg caffeine). Due to issues related to identical matching of dosage, whether GUA confers additional benefits beyond its CAF content cannot be determined at present.