bluuebunny/crossref_metadata_2025_split huggingface dataset:
The addition of acetic acid or ethanol to orally taken aluminum salt solution enhanced its availability and then induced toxic effects
Authors: Hilmy Mehdi I. , Alhiti Sadiq M. A. , Alhabib Omar AM. , Hilmy Omar M. 
Published: December 2023

Background:Aluminum (Al) intoxication was initially reported in patients undergoing hemodialysis and then was linked to Alzheimer's disease. Man usually is exposed to Al containing antacids, vaccines or foods cooked in Al utensils. The assumption of ingesting sour juices as acetic acid or ethanol may affect favorably the degree of Al absorption is justified when taken in conjunction with the above mentioned appetizers.Materials and methods: Four groups of 10 mature male rats each were used. The drinking water (DW) containing 5mM of Al2(SO4)3 with 1% glacial acetic acid and/or 10% ethanol made available ad-libidum. Weekly body weight and each other day drinking water volume were measured. Brain and plasma analysis at and Ca were determined from blood obtained by cardiac puncture, in addition to automated complete blood count (CBC), after 10 wks of treatments.Results: The results of plasma Al levels indicated that, the addition of acetic acid or ethanol to Al containing drinking water enhanced significantly its absorption and even more when combined relative to control. This enhancement was evident as well in increased Al and Ca deposited in the brain while no change in plasma Ca. The CBC results showed highly significant thombocytopnia for the 1st time, in addition to microcytosis and hypochromia. Evidently, thrombocytopoietin synthesis, and/or action is blocked by Al from acting on the cellularity of bone marrow.Conclusion: The addition of acetic acid and/ or 10% ethanol to Al containing drinking solution enhanced Al absorption when acid is used and an addative effect when both are used. The toxic plasma level caused hypochromia, microcytosis and severe thrombocytopenia in addition to brain atrophy.
Our data on detailing metastasis localization and subtype characteristics in metastatic colorectal cancer patients treated with Bevacizumab
Authors: AKDUR Pınar , ÇİLEDAĞ Nazan , SAVRAN Burcu , OCAK DURAN Ayşe 
Published: December 2023

Aims: Our aim in this study was to determine the relationship between metastasis types and mutation subtypes in patients who were followed up in our center and received bevacizumab treatment, to determine the survival rates according to metastasis types, and to contribute to the literature on this subject.
Methods: In our study, we retrospectively evaluated 42 consecutive metastatic colorectal cancer patients who were admitted to our hospital and diagnosed with colorectal cancer, thorax-abdominal CT scans were performed in our clinic to detect possible metastases, and the presence of metastases in one or more localizations was detected and treated with Bevacizumab.
Results: The majority of colorectal cancers included in our study had the histopathological subtype of adenocarcinoma (90.5%). Genetic analyses revealed that 47.6% (20 patients) had mutant KRAS gene types, while 52.4% (22 patients) had wild type. The distribution of metastases was as follows; 31 (73.8%) cases with liver involvement, 12 (28.6%) with peritoneal involvement and 24 (57.1%) with lung involvement. In our study, median overall survival was 19 months and median disease-free survival was 7 months.
Conclusion: The results of studies to date will be useful to help predict prognosis and to select appropriate regimens for treatment. We aimed to contribute to this process by presenting our own data in our own study. However, the true role of RAS genes as prognostic markers continues to be questioned, and multicenter studies are needed on the predictive and prognostic factors of colorectal cancers.
Laparoscopic myomectomy is safe in patients with previous abdominal surgery
Authors: VARLI Bulut , BAYDEMİR Şahin Kaan , ŞÜKÜR Yavuz Emre , BERKER Bülent 
Published: December 2023

Aims: The excision of myomas is commonly carried out in symptomatic women who choose to preserve their uterus, either using an open or minimally invasive (hysteroscopy, laparoscopy, robotic) approach. Patient selection is a critical factor in achieving a successful laparoscopic myomectomy. Prior abdominal surgery was not defined as a risk factor, however, the safest approach in these cases is still the subject of intense debate The aim of this study was to evaluate the safety of laparoscopic myomectomy in patients with previous abdominal surgery.
Methods: A retrospective cohort study was conducted on the files and operative notes of the patients who underwent laparoscopic myomectomy operation in a university-hospital based gynaecology department between January 2012 and March 2017. The patients were classified into two groups; Group 1 consisted of 34 patients who had previously undergone abdominal surgery, whereas the Group 2 comprised 118 patients who had not undergone any abdominal surgery.
Results: There were no significant difference between patients with and without a history of abdominal surgery in terms of operation time, postoperative hospital stays, blood loss, rate of operative complications, or conversion rate to open surgery.
Conclusion: A history of abdominal surgery seems to have no negative impact on the safety of a subsequent laparoscopic myomectomy.
Etika dan Strategi Komunikasi Dakwah Islam Berbasis Media Sosial di Indonesia
Authors: Samsudin Dafrizal , Putri Indah Mardini 
Published: December 2023

The development of social media in the digital era has a broad influence on many dimensions of human life, including Islamic da'wah activities. Today, many da'i da'wah efforts use various social media platforms as da'wah channels. This article aims to look at various ethical issues and Islamic and Da'wah communication strategies used by Islamic preachers based on social media channels. Qualitatively, the method of writing this article is in the nature of a literature study by collecting data from the Sinta Journal and Garuda Research and Technology Dikti databases. The scope and focus of the search for articles is specifically on the theme of ethics and communication strategies and social media-based da'wah with searches based on the Google Scholar search engine. Supporting data is from books and other relevant reference sources. The results of this study found that ethically, Indonesian da'wah communicators carry out da'wah communication through social media placing the al-Qur'an, al-Hadith, namely qoulan ma'rufan, qoulan kariman, qoulan maysuran, qoulan balighan, qoulan layyinan, and qoulan sadidan as foundation for the development of an attitude of openness, fairness, courtesy, honesty, responsibility, constructiveness and hope for the ridho of Allah. Strategically, da'wah communicators maximize the space of social media platforms as a means of da'wah by filling in creative Islamic content by considering aspects of new insights and knowledge, touching emotions, language that is easy to understand, using visual and graphic technology and is attractive.
SISTEM PEMBUDAYAAN NILAI TOLERANSI BERAGAMA DALAM PROSES PEMBELAJARAN DI SMAN 8 KOTA BATAM
Authors: Afkari Sulistiyowati Gandariyah 
Published: December 2023

Abstrak
Penelitian ini bertujuan untuk mengetahui Sistem Pembudayaan Nilai Toleransi Beragama Dalam Proses Pembelajaran dan factor penghambat dan pendukung Sistem Pembudayaan Nilai Toleransi Beragama Dalam Proses Pembelajaran Di Sekolah Menengah Atas Negeri 8 Batam. Penelitian ini menggunakan penelitian deskriptif yang menggunakan pendekatan kualitatif, jenisnya penelitian ini adalah field research (penelitian lapangan). Hasil penelitian tentang Sistem Pembudayaan Nilai Toleransi Beragama Dalam Proses Pembelajaran Di Sekolah Menengah Atas Negeri 8 Batam Khususnya di Kelas XII IPS 5, diperoleh system tersebut sebagaimana yang telah ditemukan yaitu adanya kegiatan sosialisasi pembudayaan nilai toleransi beragama, pembelajaran yang menanamkan sikap, pembinaan, pengajaran, orientasi pembelajaran dengan memberikan perhatian lebih pada pembudayaan nilai toleransi beragama dan pembelajaran mengenai saling menghargai dan menghayati ajaran sikap.Sedangkan hasil temuan penelitian dari faktor penghambat sistem pembudayaan nilai toleransi beragama dalam proses pembelajaran di Sekolah Menengah Atas Negeri 8 Batam Khususnya di Kelas XII IPS 5 yaitu belum dilaksanakannya penilaian kompetensi sikap, belum ada penentuan waktu yang ditetapkan untuk mengevaluasi atau mengoreksi tentang sikap, minimnya jam pelajaran dan kurangnya pemasukan dana dalam pengelolaan rumah ibadah. Selanjutnya temuan penelitian dari factor pendukung yaitu adanya hubungan yang baik antara guru dan siswa dan adanya kesadaran dari siswa terhadap pembudayaan nilai toleransi beragama dalam proses pembelajaran.
Kata kunci: Pembudayaan, Toleransi, Beragama, Pembelajaran.
KEPEMIMPINAN KEPALA MADRASAH DALAM MENINGKATKAN MUTU MADRASAH ALIYAH NEGERI DI PROPINSI JAMBI
Authors: Yusraini Yusraini , Hindun Hindun 
Published: December 2023

Kepemimpinan Kepala Madrasah dalam Meningkatkan Mutu Madrasah Aliyah Negeri di Propinsi Jambi, kemampuan kepala madrasah mewujudkan madrasah yang bermutu itu merupakan tanggung jawab utama bagi kepala madrasah sebagaimana termaktub dalam pasal 12 ayat 1 PP 28 tahun 2009. penelitian ini dimenggunakan studi kualitatif dengan pendekatan naturalistik dan metode pengumpulan menggunakan metode observasi, wawancara dan dokumentasi, teknik analaisis data meliputi reduksi data, penyajian dan penarikan kesimpilan datasedangkan uji kepercayan data dilakukan dengan perpanjanagan keikutsertaan ketelitian pengamatan dan trianggulasi. Hasil penelitian ini menunjukan bahwa indikator madrasah yang bermutu dilihat dari dilihat dari peringkat akreditasi yang diperoleh oleh madrasah dan berarti MAN tersebut telah melaksanakan proses penilaian kelayakan madrasah terhadap 8 standar yang telah ditentukan Badan Akreditasi Nasional (BAN).
Influence of meteorological conditions of the year on the biochemical composition of sorghum grain
Authors: Bychkova V. V. , Kibalnik O. P. , Sazonova I. A. , Kameneva O. B. 
Published: December 2023

Relevance. Currently, the study of the interaction of these traits with each other is a very important task of breeding. In the work, 15 varieties of grain sorghum were studied, differing in morphological parameters, growing season, degree of grain ripening, biochemical composition and yield of grain and green mass. The purpose of the study is to study the interaction of environmental conditions on the yield and biochemical composition of sorghum grain and to assess the significance of these relationships.Methods. The studies were conducted in 2020, 2021 and 2022. The years of research differed in meteorological conditions (hydrothermal Selyaninov coefficient (SCC) was 0.56–0.76). To assess the biochemical composition in sorghum grain, the spectroscopy method was used using an infrared analyzer Spectra Star XT. The grain yield was determined according to the generally accepted method. Results. The experimental results were processed using the “Agros 2.09” software package by the method of correlation analysis. Based on the results of three years of research, a correlation was established between biochemical composition and the meteorological conditions of the year (sum of temperatures, total precipitation, SCC), as well as a significant effect of these traits on the yield of sorghum grain.
La Inteligencia artificial y el futuro de la educación superior:
Authors: Zamora Varela Yessika , Mendoza Encinas Maria del Carmen 
Published: December 2023

El desarrollo de nuevas tecnologías ha permeado en todos los ámbitos, la educación se considera como una de las menos expuestos a estas. A lo largo de las últimas dos décadas, las instituciones han invertido dinero, esfuerzos y personal en la implementación de las nuevas tecnologías, con el objeto de preparar a los alumnos para su uso y aplicación.
En este contexto, la Inteligencia Artificial cobra gran importancia. En cuanto a los orígenes de este tipo de inteligencia, se puede mencionar que tuvo sus inicios en los años cincuenta, pero es hasta el inicio de este siglo que las compañías desarrolladoras han empezado a ofrecer sus productos al público en general.
El presente trabajo hace una reflexión sobre la Inteligencia Artificial y su papel en la educación superior en América Latina, con una aproximación a los desafíos que enfrenta y las oportunidades que plantea, desde un punto de vista documental. De igual forma, realiza recomendaciones pertinentes para el planteamiento metodológico del uso de la Inteligencia Artificial, en el marco educativo en este nivel.
A través de la aplicación de una encuesta como instrumento de medición del conocimiento, aproximación y opinión sobre la Inteligencia Artificial, se realizó el análisis pertinente para desarrollar de manera adecuada los planteamientos metodológicos.
El instrumento se constituye de 20 preguntas, algunas son de opción múltiple y otras de respuestas abiertas, que permiten analizar el conocimiento, tipos de uso, percepción de facilidad, utilidad, eficiencia y eficacia de las herramientas o sistemas de inteligencia artificial utilizados.
Los resultados demuestran un uso y aplicación de esta inteligencia, por un porcentaje importante de la población. Al mismo tiempo, presentan la necesidad de desarrollar lineamientos claros para su uso en el ámbito educativo y una clara necesidad de aclarar conceptos éticos relacionados.
Finalmente, en este trabajo se presentan recomendaciones aplicables a la estrategia sobre la Innovación Tecnológica en la Educación, dentro del Consenso de Beijín sobre la Inteligencia Artificial en la Educación. En estas se incluyen los principales aspectos relacionados con el rol del docente, regulaciones sobre con los derechos de autor, requisitos de recursos humanos, tecnológicos y de capacitación e inclusión en la currícula de nivel superior.
Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems
Authors: Zhang Chen , Chang Feng , Miao Hui , Fu Yunhui , Tong Xikui , Feng Yu , Zheng Wenyun , Ma Xingyuan 
Published: December 2023

During the development of traditional Chinese hamster ovary (CHO) cell lines, target genes randomly integrate into the genome upon entering the nucleus, resulting in unpredictable productivity of cell clones. The characterization and screening of high-yielding cell lines is a time-consuming and expensive process. Site-specific integration is recognized as an effective approach for overcoming random integration and improving production stability. We have designed a multifunctional expression cassette, called CDbox, which can be manipulated by the site-specific recombination systems Cre/lox and Dre/rox. The CDbox expression cassette was inserted at the Hipp11(H11) locus hotspot in the CHO-K1 genome using CRISPR/Cas9 technology, and a compliant CHO-CDbox cell platform was screened and obtained. The CHO-CDbox cell platform was transformed into a pool of EGFP-expressing cells using Cre/lox recombinase-mediated cassette exchange (RMCE) in only 2 weeks, and this expression remained stable for at least 75 generations without the need for drug stress. Subsequently, we used the Dre/rox system to directly eliminate the EGFP gene. In addition, two practical applications of the CHO-CDbox cell platform were presented. The first was the quick construction of the Pembrolizumab antibody stable expression strain, while the second was a protocol for the integration of surface-displayed and secreted antibodies on CHO cells. The previous research on site-specific integration of CHO cells has always focused on the single functionality of insertion of target genes. This newly developed CHO cell platform is expected to offer expanded applicability for protein production and gene function studies.
In-hospital and 1-year outcomes of patients without modifiable risk factors presenting with acute coronary syndrome undergoing PCI: a Sex-stratified analysis
Authors: Sheikhy Ali , Fallahzadeh Aida , Jameie Mana , Aein Afsaneh , Masoudkabir Farzad , Maghsoudi Milad , Tajdini Masih , Salarifar Mojtaba , Jenab Yaser , Pourhosseini Hamidreza , Mehrani Mehdi , Alidoosti Mohammad , Vasheghani-Farahani Ali , Hosseini Kaveh 
Published: December 2023

AimA considerable proportion of patients admitted with acute coronary syndrome (ACS) have no standard modifiable cardiovascular risk factors (SMuRFs: hypertension, diabetes mellitus, dyslipidemia, and cigarette smoking). The outcomes of this population following percutaneous coronary intervention (PCI) are debated. Further, sex differences within this population have yet to be established.MethodsThis retrospective cohort study included 7,847 patients with ACS who underwent PCI. The study outcomes were in-hospital mortality, all-cause mortality, and major adverse cardio-cerebrovascular events (MACCE). The association between the absence of SMuRFs (SMuRF-less status) and outcomes among all the patients and each sex was assessed using logistic and Cox proportional hazard regressions.ResultsApproximately 11% of the study population had none of the SMuRFs. During 12.13 [11.99–12.36] months of follow-up, in-hospital mortality (adjusted-odds ratio (OR):1.51, 95%confidence interval (CI): 0.91–2.65, P:0.108), all-cause mortality [adjusted-hazard ratio (HR): 1.01, 95%CI: 0.88–1.46, P: 0.731], and MACCE (adjusted-HR: 0.93, 95%CI:0.81–1.12, P: 0.412) did not differ between patients with and without SMuRFs. Sex-stratified analyses recapitulated similar outcomes between SMuRF+ and SMuRF-less men. In contrast, SMuRF-less women had significantly higher in-hospital (adjusted-OR: 3.28, 95%CI: 1.92–6.21, P &lt; 0.001) and all-cause mortality (adjusted-HR:1.41, 95%CI: 1.02–3.21, P: 0.008) than SMuRF+ women.ConclusionsAlmost one in 10 patients with ACS who underwent PCI had no SMuRFs. The absence of SMuRFs did not confer any benefit in terms of in-hospital mortality, one-year mortality, and MACCE. Even worse, SMuRF-less women paradoxically had an excessive risk of in-hospital and one-year mortality.
Assessment of causal association between differentiated thyroid cancer and disordered serum lipid profile: a Mendelian randomization study
Authors: Ma Qiang , Li Yu , An Lijuan , Guo Liang , Liu Xiaokang 
Published: December 2023

BackgroundResearch has shown that the disordered serum lipid profile may be associated with the risk of differentiated thyroid cancer (DTC). Whether this association reflect causal effect is still unclear. The aim of this study was to evaluate the causality of circulating lipoprotein lipids on DTC.MethodsMendelian randomization (MR) analysis was conducted to evaluate the relationship between the circulating lipoprotein lipids and DTC risk using single-nucleotide polymorphisms (SNPs) from a genome-wide association (GWA) study containing a high-incidence Italian population of 690 cases samples with DTC and 497 controls.ResultsUnivariate and multivariate mendelian randomization analysis demonstrated that ‘total cholesterol’, ‘HDL cholesterol’, ‘apolipoprotein B’ and ‘ratio of apolipoprotein B to apolipoprotein A1’ were correlated with DTC. According to sensitivity analysis, our results were reliable. Furthermore, multivariate analysis revealed that there is no causative association between DTC and any of the many cause factors when they interact with one another, suggesting that there was a deep interaction between the four factors, which could affect each other. Finally, the mechanism of the related effects each other as well as the target genes with significant SNP regulatory effects in DTC was explored by conducting functional enrichment analysis and constructing the regulatory networks.ConclusionsWe obtained four exposure factors (total cholesterol, HDL cholesterol, apolipoprotein B and ratio of apolipoprotein B to apolipoprotein A1) closely related to DTC, which laid a theoretical foundation for the treatment of DTC.
Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study
Authors: Liang Zhuo-Yuan , Lu Zhi-Hao , Qu Jian-Feng , Chen Yang-Kun 
Published: December 2023

BackgroundThe non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.MethodsWe performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.ResultsEleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, P&lt;0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates &lt;60 ml/min/1.73m2) (55% vs. 20%, P=0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.ConclusionA higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC.
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol
Authors: Giles Michelle L. , Cole Stephen , O’Bryan Jessica , Krishnaswamy Sushena , Ben-Othman Rym , Amenyogbe Nelly , Davey Mary-Ann , Kollmann Tobias 
Published: December 2023

Maternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause of childhood morbidity and mortality globally. Our overarching question is: how does maternal immunisation modify the immune system in pregnant women and/or their newborn to reduce adverse pregnancy outcomes and enhance the newborn infant’s capacity to protect itself from infectious diseases during early childhood? To answer this question we are conducting a multi-site, prospective observational cohort study collecting maternal and infant biological samples at defined time points during pregnancy and post-partum from nulliparous women. We aim to enrol 400 women and determine the immune trajectory in pregnancy and the impact of maternal immunisation (including influenza, pertussis and/or COVID-19 vaccines) on this trajectory. The results are expected to identify areas that can be targeted for future intervention studies.