bluuebunny/crossref_metadata_2025_split huggingface dataset:
Islet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen
Authors: Wentworth John M. , Sing Anna B. E. , Naselli Gaetano , Huang Dexing , Azidis-Yates Elizabeth , Mandlebe Batsho , Brown James D. , McGorm Kelly , Hall Candice , Redl Leanne , Kludas Renee , Haldar Aniruddh , Healy Felicity , Gilbert Abbey , Watson Kelly , Chiang Cherie , Couper Jennifer J. , Huynh Tony , Davis Elizabeth A. , Craig Maria E. , Cameron Fergus J. , Kay Thomas W. , Harrison Leonard C. , Colman Peter G. 
Published: January 2025

OBJECTIVE
Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) with the dual aims of preventing diabetic ketoacidosis (DKA) and enabling use of disease-modifying therapy. We describe screening and monitoring outcomes 2 years after implementing in-home capillary blood spot sampling.

RESEARCH DESIGN AND METHODS
Data from 2,064 participants who registered between July 2022 and June 2024 were analyzed: 1,507 and 557 chose blood spot and venipuncture screening respectively. We compared baseline characteristics and outcomes for 1,243 participants (967 blood spot and 276 venipuncture) whose samples were tested by June 2024.

RESULTS
One blood spot and five venous participants reported unsuccessful sample collections. The median (quartile 1, quartile 3) age of blood spot registrants was lower (12.1 [7.1, 27.1] vs. 17.2 [9, 38.4] years; P &lt; 0.0001), and a higher proportion lived in regional Australia (39% vs. 29%; P = 0.0037). Among 72 participants (5.9%) with a positive screening test, 5 screened by blood spot and 2 by venipuncture had no autoantibodies on confirmatory testing. Blood spot screening identified the expected 2.1% prevalence of multiple autoantibodies and a 2.5% prevalence of a single autoantibody compared with 1.5% and 4.1%, respectively, for venipuncture screening. Clinical diabetes developed in 12 participants. All had screened positive and none had DKA.

CONCLUSIONS
Type1Screen has national reach. In-home blood spot screening is feasible, particularly for younger participants living regionally, and identifies the expected prevalence of preclinical T1D. The lower cost, increased convenience, and greater reach of blood spot screening could help meet increasing demand for early T1D diagnosis.
Mixted Optimization With Multi-Peaks Diet for Controlling the Glycemic Profil of the Diabetic Patients
Authors: Moutaouakil Karim El , Ez-Zaiym Mustapha , Ouissari Abdellatif El , Rajafilla Chaymae , Baizri Hicham 
Published: January 2025

Objective: The objective of this study is to develop an efficient glucose management system based on an original control model with mixed constraints (dynamic and static constraints) to manage diets with several thresholds, using Bergman’s minimal model and Fischer’s meal models.

Theoretical Framework: Personalized and healthy diets play a significant role in controlling the progression of diseases such as type 2 diabetes. Existing glucose management methods are predominantly based on dynamic mathemati- cal models and focus on diets with a single peak. However, diets with multiple thresholds better reflect realistic dietary patterns and enable more comprehen- sive glucose control.

Method: The proposed model combines two key components: an objective function that minimizes the total error between the basic and generated glucose and the quantity of diet, and constraints that incorporate dynamic differential equations (Bergman’s minimal model) and static constraints representing the interval between two sensitive meals. To solve this model, the integral in the objective function is discretized using the trapezoidal rule, and dynamic con- straints are approximated using the Euler-Cauchy method. A genetic algorithm is employed to optimize the resulting static model. Several study cases, including global, partial, and one-off scenarios, are considered.

Results and Discussion: Numerical simulations demonstrate that the pro- posed system effectively estimates sufficient personalized diets, grading the glycemic profile within a defined confidence zone. This approach accounts for three critical dimensions: the quantity of food, its distribution, and the intervals between successive meals. Optimal management of these parameters results in maximum dietary intake, low glucose generation, and minimal insulin secretion, enabling diabetics to maintain a near-normal lifestyle.

Research Implications: This study provides a realistic and innovative frame- work for glucose management, considering the complexities of real-life dietary patterns. It highlights the significance of integrating dynamic and static con- straints in glucose control systems and contributes to the design of personalized dietary strategies for individuals with diabetes.

Originality/Value: This work contributes to the literature by introducing a novel glucose management system that considers diets with multiple thresholds, enabling better control of glycemic profiles and improving the quality of life for individuals with diabetes.
Insecurity as An Influential Factor In The Tourism Development of the Historical Center of Quito
Authors: Belén Calderón Galora Susana , Mateo Vásquez Galeas Rafael , Damián Almeida Peñaherrera Jefferson , Leonidas Vizuete Apunte Jorge , Andrés Terán Andrade Jairo 
Published: January 2025

Objective: The objective of this study is to investigate insecurity as an influential factor in the tourist development of the Historic Center of Quito, with the aim of identifying management and control strategies that regularize the social problems of this sector.

Theoretical Framework: This topic presents the main concepts and theories that support the research. Security in Quito and its Historic Center and tourism development stand out, providing a solid basis to understand the context of the research.

Method: The methodology of the study has a descriptive scope and a mixed approach in terms of data analysis, on the one hand, qualitative through bibliographic research and quantitative through virtual surveys applied to tourists from the Historic Center of Quito.

Results and Discussion: The results obtained revealed that informal commerce, homeless people, micro traffic, prostitution, neglected and abandoned real estate, poor lighting, among others, are several of the causes that generate perception of insecurity in tourists.

Research Implications: The research involved the identification of the main social problems that generate insecurity in the Historic Center of Quito, and where tourism development can be improved through strategies.

Originality/Value: Ecuador, and mainly its capital Quito, is going through unprecedented waves of insecurity, which has generated new social problems such as those detailed in the results obtained (informal commerce, homeless people, micro-trafficking, prostitution, abandoned real estate, among others). others) and that directly influence the tourism sector and its development, which is why this study proposes new measures and strategies according to current needs.
Evolución metropolitana contemporánea.
Authors: Sousa-González Eduardo 
Published: January 2025

Seguramente se estará de acuerdo en que la manifestación fenomenológica vinculada con las ciudades y de éstas, su evolución en zonas metropolitanas es paulatina, progresiva, replicable y ciertamente irreversible; indudablemente esta expresión del espacio territorial ocurre no solo en México como país, ya que la expresión de lo urbano en la contemporaneidad, se percibe claramente con diversas dinámicas expansivas en el sur global y prácticamente en todo el mundo conocido.
No cabe la menor duda, que el futuro global tendrá indiscutiblemente una tendencia evolutiva y progresiva en el crecimiento del número y la dimensionalidad de las ciudades; en donde muchas de ellas en su proceso evolutivo transformacional se convertirán en metrópolis y aquellas que ya lo son, seguramente continuarán con su crecimiento expansivo periférico ensanchando su espacio territorial ocupando procesalmente y sin tregua el suelo originario quizá ad perpetuam.
A new test system for Salmonella detection in food products by competitive immonoassay
Authors: Kiseleva E. P. , Mikhailopulo K. I. , Sviridov O. V. 
Published: January 2025

Detecting Salmonella in foods is topical due to the known cases of salmonellosis epidemics. Immunochemical methods including enzyme-linked immunosorbent assay (ELISA) have been widely used in Salmonella detection. Traditionally, ELISA of Salmonella is based on detecting lipopolysaccharide (LPS), which is considered to be the main structural component of the outer membrane of the cell of Gram-negative bacteria. Core (conservative LPS element common to all Salmonella) and O-antigen (hypervariable LPS element) are available for interaction with antibodies. It was shown using commercial MAb 5D12A (to the core of LPS) or MAb 10D9H (to the common epitope of the O-antigen of Salmonella serogroups A, B and D) that in the Salmonella culture obtained during sample preparation, traditional for the analysis of these bacteria in foods, LPS is present mainly outside cells, in the medium (no less than 90 %). It has been found that the addition of centrifugation to the standard sample preparation procedure to separate bacteria from the medium and a subsequent analysis of the medium can expand the test-system working range towards lower LPS concentrations and increase the analytical sensitivity. It has been shown that immobilization of the bovine serum albumin (BSA)-LPS conjugate in the wells of a microplate immunosorbent allows one to obtain a more homogeneous coating than immobilization of LPS itself. We have elaborated 2 test systems for Salmonella detection in foods by competitive ELISA of LPS secreted in medium. In each of the two test systems, the BSA-LPS conjugate is immobilized on the solid phase, and in the liquid phase there are either MAb 5D12A or MAb 10D9H. The sensitivity of the analysis for each test system is 105 CFU/ml. The test system based on MAb 5D12A is advan tageous since it allows detecting all Salmonella regardless of serotype.
Genotypic features of the relationship between the components of the antioxidant complex of high blueberry fruits and the content of organic compounds during introduction in Belarus
Authors: Rupasova Zh. A. , Avramenko S. N. , Ushakova A. V. , Pavlovsky N. B. , Drozd O. V. , Bely P. N. , Shpitalnaya T. V. , Vecher N. N. 
Published: January 2025

The article presents the results of a comparative study in the southern agroclimatic zone of Belarus in the taxonomic series of 6 new introduced varieties of highbush blueberry: early ripening – Chanticleer, Hannah’s Choice, midseason – Bluegold, Harrison, and late ripening – Aurora, Rubel, as well as the corresponding to these maturity groups zoned varieties Weymouth, Bluecrop and Elliott structures of correlation links between the levels of antioxidant and enzymatic activity, on the one hand, and 12 indicators of biochemical composition, on the other.Significant genotypic differences in the orientation and strength of these links were revealed due to the individual characteristics of the biochemical composition of the tested objects, indicating a pronounced variety specificity of the analyzed traits.A noticeable similarity was revealed in the representatives of different varietal groups in the spectra of organic compounds most significant for formation of the antioxidant complex of fruits, which was most clearly manifested in early and late ripening varieties and consisted of the dominant role of catechins, tannins, leucoanthocyanins and flavonols, and in midripening varieties – along with tannins and leucoanthocyanins, also free organic and hydroxycinnamic acids.At the same time, soluble sugars and ascorbic acid had the least effect on the antiradical properties of blueberry fruits. A uniform sequence of blueberry taxa was established in the order of decreasing the interaction level of individual components of the antioxidant complex of fruits with the content of organic compounds of different chemical nature with the greatest manifestation of the strongest direct correlation links with sources of antioxidant, peroxidase and polyphenoloxidase activity in the Hannah’s Choice variety, and in the Aurora variety – with sources of catalase and, to a lesser extent, the peroxidase activity against the background of a minimum number of such interactions in the Harrison variety, which was 1.6–2.1 times inferior in this feature to the leading blueberry taxa.
Directions for stimulating the expansion of the practice of using domestically selected vegetable seeds
Authors: Makrak S. 
Published: January 2025

A developed mechanism for implementing instruments of state support for the seed industry in the context of stimulating the use of domestic vegetable seeds is presented, including an algorithm for assessing the priority of specific measures to motivate their purchase.Based on an analysis of the production and economic indicators of vegetable cultivation in a focus group of commodity producers, practice-oriented measures were developed to increase the efficiency of the vegetable growing industry, aimed at the use of compensation payments for certain types of material resources.
Petrus, die Reinigung der Herzen und die Inklusion in das Volk Gottes (Apg 15,9)
Authors: Hammann Christoph 
Published: January 2025

Abstract
In his speech at the assembly of the apostles in Jerusalem (Acts 15:6–21), Peter argues for accepting the non-Jewish Christ believers (the ἔθνη) as full members of God’s people. One of his statements (Acts 15,9) contains the terms καθαρίζω, καρδία and πίστις, resulting in an expression quite unusual for Luke. According to Peter, God has purified the hearts of the ἔθνη by faith.
The present article sheds light on the motif of the purification of hearts expressed in Acts 15:9. It examines how this motif relates to Greco-Roman anthropology, especially to philosophical and medical concepts of that time. In doing so, it raises the following questions: Is the idea expressed in Acts 15:9 compatible with these concepts, and is there a further dimension the motif of the purification of hearts unfolds compared to these models? Thereby, the article explores the potential of Acts 15:9 in the dialogue with educated pagan readers.
Influence of tryptophan on histomorphometric changes of the brown adipose tissue in rats
Authors: Yanko R. 
Published: January 2025

Literature data on the effects of tryptophan on brown adipose tissue (BAT) are ambiguous. Its role in BAT with existing pathology in the body, primarily obesity, was mainly studied. However, the effect of the use of tryptophan on the functioning of a healthy BAT is little studied. The aim of this work was to study the effect of L-tryptophan on the histomorphometric parameters of the BAT in healthy rats. The study was conducted on male Wistar rats, whose age at the beginning of the experiment was 3 months. Rats were divided into 2 groups (12 animals in each): I group – control, II group – experimental animals, which received daily oral L-tryptophan at a dose of 80 mg/kg body weight. Work with rats was carried out in accordance with the principles of the Declaration of Helsinki. Histological preparations were made from the interscapular bodies of the BAT according to the standard me­thod. Micropreparations of the BAT were photographed using a digital camera. Morphometry of the BAT was carried out on digital images using the computer program “Image J”. Histomorphometric analysis of the BAT of rats treated with L-tryptophan revealed an increase in the number of adipocytes with one large lipid droplet (12 times more) and a smaller number of brown adipocytes (1.5 times less). The size of adipocytes increased due to an increase in the area of lipid droplets (by 174 %) located in the cytoplasm. A decrease in the area of the nucleus, the nuclear-cytoplasmic ratio, and the number of nucleolus indicates inhibition of the synthetic activity of adipocytes. An increase in the relative area of connective tissue (by 13 %) and a decrease in the area of blood vessels (by 27 %) were also found in the BAT of these rats, which indicates worse perfusion, inhibition of oxygen transport to parenchymal elements, deterioration of conditions for metabolic processes. Therefore, a 28-day exposure to L-tryptophan has morphological signs of a decrease in the functional activity of BAT in healthy rats and leads to the process of its «whitening» – transformation into white adipose tissue. Therefore, despite the researched positive effect of tryptophan on many organs, it should be taken carefully so as not to harm the functioning of the BAT.
Local leadership and local self-government in the context of austerity: the European experience
Authors: Kugai Aleksandr Ivanovich 
Published: January 2025

The chapter examines the problems that are solved by local authorities and local political leaders in the European context. Three specific approaches have been identified that can be used by central and regional authorities in relation to local self-government, as well as by political leaders in managing their territories: corporate (joint), coercive and conceptual. Cooperative in nature and based on the pooling of local and national resources and political potential, both by local leaders and through interaction between levels of government. The coercive approach is based either on direct political control – through the power of the central government (and local leaders), or on the use of pressure, political persuasion or incentives, where direct political control is exercised. The conceptual model recognizes the need to address the gap between what is politically feasible – what local government and local leaders can do and achieve – and reality. Understanding this conceptual gap is essential given the pace of change in local government and the varying capabilities of local leaders to respond to emerging challenges such as austerity.
Strategic management approaches in the evolution of cinema chains
Authors: Pytel Dawid , Bugaj Justyna 
Published: January 2025

This article delves into the critical role of strategic management in the context of cinema chains, aiming to identify the key strategic elements that influence their development and operation. It addresses two primary research questions: “What are the main strategic elements that impact the development of cinema chains?” and “How do strategic management components such as market positioning, innovation, strategic planning, analysis, formulation, and implementation assist cinema chains in navigating market challenges, including the shift to digital content distribution?” This study contributes meaningfully to the discourse on strategic management within the entertainment sector, offering practical insights for decision-makers in cinema chains. The research involved a comprehensive literature review, utilizing renowned academic sources such as Scopus, EBSCO, and JSTOR, covering publications from 1990 to 2022. This approach aimed to dissect the complex layers of strategic management in the cinema industry, shedding light on the unique challenges and opportunities within this segment of the entertainment market. Our research highlights a notable gap in the existing literature concerning strategic management practices specifically within the realm of cinema chains. This deficiency points to a need for more focused research in this area. Based on our findings, it is recommended that cinema chains prioritize the adoption of technological innovations and diversify their revenue streams to remain competitive. Strategic adaptability, informed by continuous monitoring of internal and external factors, is essential for sustainable growth in the rapidly evolving film industry. The findings of this study could significantly enrich the academic dialogue and offer pragmatic advice for industry practitioners. The identified gap in the literature underscores the urgency of initiating primary research, such as surveys, interviews, or case studies, in the field of cinema chain management. Such research promises to deepen the empirical understanding of strategic management practices and provide actionable guidance for industry stakeholders.
On the issue of improving the higher education system in Russia
Authors: Afanasiev Mikhail 
Published: January 2025

The paper provides a statistical analysis of students&apos; preferences regarding the choice of a &quot;two-stage&quot; and &quot;three-stage&quot; higher education system. The data from the student survey is used. The main purpose of the study was to analyze the students&apos; opinions on building a priority higher education system. The results of comparing the estimates of the parameters of logit and probit models allowed us to conclude that the characteristics of age, level of education, number of years in the higher education system do not have a statistically significant effect on students&apos; preferences in a hypothetical choice of an education system: a &quot;three-stage&quot; or &quot;two-stage&quot; system. The study also showed that students of different fields of study have different views on the issue of the priority education system.
Creating an effective organization
Authors: Beljonova Nina 
Published: January 2025

The paper provides an overview of methods of building an effective organization that ensures maximum return on the resources used in the process of achieving its set goals. The article consists of three parts, which describe: an optimization approach to building an organization&apos;s structure, consisting of analyzing and using the properties of a mathematical model of the system; an organization management methodology based on key performance indicators (KPI), allowing you to track the results of the organization&apos;s activities and identify problem areas in management; a methodology based on the use of lean manufacturing methods and tools aimed at eliminating excess costs and optimizing production indicators.
The advantages and disadvantages of the described methodologies, proven by domestic and foreign practice, are noted, as well as the reasons for frequent implementation failures and possible measures to overcome them.