bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micellar Curcumol for Maintenance Therapy of Ovarian Cancer by activating the FOXO3a
Authors: Wang Jing , Chen Bing , Yang Jiezhen , Tang Qin , Zhong Yan , Du Jijun , Wang Sheng , Wu Qiang , Lu Yang , Song Yonghong 
Published: January 2024

Abstract
Background: Maintenance therapy (MT) after postoperative platinum-based chemotherapy for ovarian cancer (OC) is crucial for delaying or preventing disease relapse. The current targeted drugs are only effective in about 30% of OC patients and the options for MT are limited. FOXO3a was considered as a potential target of chemotherapeutic drugs for OC due to its key role in inhibiting disease progression and recurrence. Curcumol, a major constituent of the plant Rhizoma Curcumae, is a low-toxic and effective anti-cancer drug which indicates that it is a potential candidate for MT. However, curcumol is indissolubility in water, with low bioavailability, and its pharmacological basis is unclear. Herein, Micellar curcumol (MC) was prepared for the therapy of OC. Parallel assessments of the anti-tumor ability and mechanism of MC were performed on two kinds of OC cells.
Results: The results indicated that the IC50 of MC in two OC cells were as low as 37.69±2.43 and 28.54±1.58 μg/mL, respectively. Curcumol, by inhibiting phosphorylation at the AKTT308 site, activates the transcriptional activity of FOXO3a, which further promotes the recruitment of FOXO3a to the promoter sequence of endoplasmic reticulum stress-related PERK genes, inducing OC cells apoptosis. Moreover, the DiR-labeled MC could quickly accumulate in the tumor region within only 1h and maintain for 48 h in vivo. Further, MC inhibited the growth of SKOV3 cells on tumor-bearing nude mice by intravenous injection.
Conclusions: Micellar loaded curcumol provides great feasibility to achieve efficient MT for OC based on the nanoplatforms of active ingredients from natural products.
Comparison of therapeutic effects between Nice knot combined with locking plate and lag screw combined with locking plate in the treatment of comminuted midclavicular fracture in adults
Authors: Wang Zeyong , Yang Fei , Zhu Yiran , Qin Jian , Yuan Tangbo 
Published: January 2024

Abstract
Objectives: To compare the clinical outcomes of Nice knot combined with locking plate and lag screw combined with locking plate in the treatment comminuted midclavicular fracture in adults.
Methods: All eighty patients completed surgical treatment and received complete follow-up were retrospective analysised with comminuted midclavicular fracture admitted to our hospital from December 2019 to December 2021. Who underwent Nice knot combined with locking plate fixation (NKLP, n＝44) or lag screw combined with locking plate fixation(LSLP, n＝36) . The two groups were compared with the operation time, intraoperative blood loss, visual analogue scale (VAS) postoperatively, postoperative internal fixation complications including postoperative infection, internal fixation loosening, rupture, and fracture displacement. Shoulder function was tested by Neer scores, Constant-Murley scores at follow-up, and university of California at Los Angeles shoulder rating scale (UCLA) scoring system was used in the last follow-up.
Results: All patients were followed up for 12 to 24 months with an average time of (13.2 ± 1.5) months. The NKLP and LSLP groups comprised 44 patients (age, 42.0±9.5 years; 26 men) and 36 patients (age, 41.9±8.3 years; 22 men) ,respectively. The NKLP group had less operative time (50 ± 4 vs 63 ± 6 min, P＜0.001), intraoperative blood loss (35 ± 4 vs 54 ± 5 ml, P＜0.001), the VAS scores on 2 days (3.7±0.6vs 4.1±0.8, p＝0.01 ) and one month (2.7±0.5 vs 3.0±0.8, p＝0.04 ). And had higher Neer scores (68.1±1.9 vs 65.5±2.4, P＜0.001) and Constant-Murley scores (69.1±2.0 vs 66.5±2.1, P＜0.001) on one month after surgery (P<0.05). But there were no obvious differences in the VAS scores(0.7±0.6 vs 0.8±0.7, p＝0.766 ) , the Neer scores (94.0±1.5 vs 93.4±1.7, p＝0.061) and the Constant-Murley scores (94.5±2.2 vs 93.3±3.1, p＝0.132) in the last follow-up. The satisfactory and excellent rates with university of California at Los Angeles shoulder rating scale (UCLA) scoring system of postoperative treatment were respectively 93% (41/44) and 87% (31/36) in two groups (p＝0.871).
Conclusions: The two groups are secure and effective in the treatment for comminuted midclavicular fracture. The NKLP group has the advantages of simple operation, shorter surgical time, and especially for small sphenoid bone blocks that are difficult to fix with lag screw in the fixation of comminuted midclavicular fracture than the LSLP group. It is worthy of clinical promotion and application. Key words: Bone; Clinical Outcomes; Fracture; Treatment ; Therapeutics.
Guard2Vul: Vulnerability Detection viaGradient-based Adversarial TrainingEnhanced Graph Learning
Authors: Shen Hao , Ju Xiaolin , Li Wenjie , Chen Xiang , Yang Guang 
Published: January 2024

Abstract

Modern software security is challenged by vulnerabilities, which canlead to severe consequences, including loss of information, property, andprivacy disclosure. Recently, graph-based deep learning methods havebeen proven as a promising solution for vulnerability detection at func-tional granularity. However, previous studies still face challenges, suchas structural imbalances, complex connections in abstract syntax treesof functions, and insufficient training data. In this study, we proposeGuard2Vul, which combines a graph neural network with a residualnetwork to jointly capture deeper semantic and structural features,specifically, source code and node dependencies. Moreover, we utilizeGraphSMOTE and DGD, a dropout-enhanced gradient adversarial train-ing technique, to conduct data augmentation and automatically improvenormalized stability. To demonstrate the effectiveness of Guard2Vul, we evaluate its performance on four experimental subjects by different pro-gramming languages, such as C/C++ and Java. To show the competitive-ness of Guard2Vul, we consider five Deep Learning-based vulnerabilitydetection approaches (i.e., TokenCNN, Sysevr, VulDeePecker, Devign,and Reveal) as baselines. The results indicate that Guard2Vul out-performs these baselines, achieving at least 13.4%, 28.9%, 6.2%, and12.1% higher F1-measure on four experimental subjects. Finally, weperform ablation experiments to demonstrate the effectiveness of ourcustomized components, namely enhanced graph representation learningand the gradient-based adversarial training method, in Guard2Vul.
Conservative vs. Liberal Glycoprotein IIb-IIIa Antagonist Strategies in the Treatment of ST-Elevation Myocardial Infarction: A Dual-Center Analysis
Authors: Potter Brian J. , Callichurn Kashi , Simard Philippe , De Marco Corrado , Jamali Payman , Saada Yacine , Matteau Alexis , Schampaert Érick , Mansour Samer , Hatem Raja 
Published: January 2024

Abstract
Background
While the efficacy of GpIIb-IIIa-inhibitors during primary PCI (pPCI) for ST-elevated myocardial infarction (STEMI) has previously been demonstrated, its ongoing role and safety in combination with newer P2Y12-inhibitors is unclear. We therefore sought to compare outcomes between two centers with divergent approaches to the use of GpIIbIIIa antagonists in pPCI.
Methods
We performed a retrospective chart review of all-comer STEMI patients treated with pPCI at two high-volume Montreal academic tertiary care centers. One center tended to use GpIIb-IIIa-inhibitors up-front in a large proportion of patients (liberal strategy) and the other preferring a bail-out approach (conservative strategy). Baseline patient characteristics and procedural data were compared between the two groups. The main efficacy outcome was rate of no-reflow/slow-reflow and the main safety outcome was BARC ³ 2 bleeding events.
Results
A total of 459 patients were included, of whom 167 (36.5%) were exposed to a GpIIb-IIIa-antagonist. There was a significant overall difference in use of GpIIb-IIIa-antagonist between the two centers (60.5% vs 16.1%, p<0.01) Rate of no-reflow/slow-reflow was similar between groups (2.6% vs 1.4%, p=0.22). In-hospital rates of unplanned revascularization, stroke and death were aslo not different between groups. Use of a liberal GpIIb-IIIa-antagonist strategy was associated with a higher risk of bleeding (OR 3.16, p<0.01), which persisted after adjustment for covariables (adjusted OR 2.85, p<0.01).
Conclusions
In this contemporary retrospective cohort, a conservative GpIIb-IIIa-antagonist strategy was associated with a lower incidence of clinically relevant bleeding without any signal for an increase in no-reflow/slow-reflow or ischemic clinical events.
Stiefel-Whitney Classes of Representations of Dihedral Groups
Authors: Bhalerao Sujeet , Joshi Rohit , Malik Neha 
Published: January 2024

Abstract
We compute the Stiefel-Whitney Classes for representations of dihedral groups Dm in terms of character values of order two elements. We also provide criteria to identify representations V which lift to the double covers of the orthogonal group O(V) and those with non-trivial mod 2 Euler class.
MSC Classification: 55R40 , 20C33 , 20G40
Parasitic RC Estimation and Defect Prediction for Embedded Memory using Machine Learning
Authors: Maddela Venkatesham , Sinha Sanjeet Kumar , Parvathi Muddapu , Chander Sweta 
Published: January 2024

Abstract
In today's rapidly scaling-down technological environment, identifying the best-fit algorithms for evaluating complicated circuits such as SRAMs is a difficult issue. Many fault models have developed, however their flexibility of use is limited by the restrictions and constraints of the provided test environment. The majority of existing fault models have been studied in terms of well-known March algorithms, which simply provide fault detection information. Scaled-down technologies have an impact on parasitic effects as well, resulting in an extra source of defective behavior and making current test algorithms vulnerable to them. Recent work that uses method of parasitic extraction for fault detection have addressed the problem of limitation due to scale down technologies. However, as the circuit complexity increases the estimation of RC would be tedious. Hence in this paper machine learning based parasitic RC extraction is proposed. Also, as an extension to that, proposed ML based fault detection using extracted parasitic RCs as dataset. The proposed machine learning based fault prediction uses extracted parasitic RCs as dataset. The parasitic RC values are extracted for each fault model using technologies of 120nm down to deep submicron 7nm. Regression algorithm is used for modeling the machine for extraction of RCs and observed that 88% of prediction accuracy. Decision tree modeling is used for fault detection and observed 91.7% of accuracy in prediction of fault. 3.1 Effect of open defects in 6T SRAM Cell In this are article we have consider the node to node open/short faults. In Fig 2. We have imposed all possible open defects and then we have analyzed the memory cell for all possible open defects. There are totally 25 open defects are possible as shown in the fig 2. The simulation results and different types faults occurs for all open defects are shown in table 1 Fig2: Fault model for Open Defects in 6T-SRAM Cell Table 1. 6T SRAM Cell open defect list for different technologies
Nutrient release and decomposition time of Eucalyptus urograndis harvest residues practices under Brazil tropical conditions
Authors: Sena Karla Nascimento , Maltoni Kátia Luciene , Barbosa Mariana Cristina 
Published: January 2024

Abstract

The forest areas, besides their importance in the economic sector, have an important role in soil conservation when sustainable silvicultural practices are adopted. The objective of this work was to evaluate the accumulation and decomposition of eucalyptus harvest residues in Eucalyptus urograndis plantations in areas subjected to different management systems of harvest residues in eastern Mato Grosso do Sul. Litter bags were used to evaluate the decomposition of harvest residues and nutrient (N, P, K, Ca, Mg, S, and C) content of the remaining residues under different harvesting systems during a 36-month period. Harvesting in the cut to length (CTL) system provided greater phytomass and N, P, K, Ca, and C contents. The decomposition of harvest residues in the CTL system was greater during the initial months. T he removal of the bark reduced the amount of N and increased the decomposition time, as observed in the tree-length (TL) system. The amount and composition of forest harvest residues affect their decomposition and nutrient release. The forest harvest residues present mass loss as a function of decomposition time, influenced by the rainfall regime.
CircHIPK3 promotes thyroid cancer progression via miR-338-3p/RAB23 axis
Authors: Shu Taipengfei , Wang Jing , Lu Jixuan , Sun Lijie , Wang Shurui , Han Cong , Zhang Siyue , Zhan Xiaorong , Jiang Jun 
Published: January 2024

Abstract
Background: Reports have suggested circular RNAs (circRNAs) have vital functions in cancer biology. Herein, we aim to explore the function of circHIPK3 in the mechanism of thyroid cancer (TC).
Methods: The levels of circHIPK3 in TC cells and 10 paired samples were studied by qRT-PCR. Next, the effect of circHIPK3 on TC cell activities was observed by CCK-8 and Transwell assays. Subsequently, the downstream targets of circHIPK3 in TC were predicted and confirmed by dual-luciferase reporter assay.
Results: CircHIPK3 had a high expression in TC cells and samples, mainly in cell cytoplasm, and its downregulation significantly inhibits cell growth and metastasis. Then, we predicted the downstream targets of circHIPK3 in thyroid cancer were miR-338-3p and RAB23, which was confirmed by experiments later.
Conclusion: We discover that circHIPK3 can promote TC by down-regulating miR-338-3p and up-regulating RAB23, providing new ideas into the mechanism of circRNA roles in TC and demonstrating that circHIPK3 can be a promising indicator or target for TC diagnosis and treatment.
Interpretable machine learning-derived nomogram model for early detection of persistent diarrhea in Salmonella typhimurium enteritis: A propensity score matching based case-control study
Authors: Jin Longteng , Huang Yucheng , Xi Jianan , Zhan Lu , Jin Haojie , Chen Yiping , Chu Maoping 
Published: January 2024

Abstract
Salmonella typhimuriuminfection is a considerable global health concern, particularly in children, where it often leads to persistent diarrhea. This condition can result in severe health complicationsincluding malnutrition and cognitive impairment. A retrospective case-control study was carried out involving 627 children diagnosed with S. typhimuriumenteritis. The children were admitted to the Second Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2022. Propensity score matching was used to explore the potential risk factors and predictors of persistent diarrhea following S. typhimurium infection. As a result, body temperature, C-reactive protein (CRP) levels, alanine aminotransferase (ALT) levels, white blood cellcount, and lactose intolerance were significant predictors of persistent diarrhea. Nomogram models developed based on these predictors demonstrated robust performance in predicting persistent diarrhea risk, with an accuracy of > 90%.
Conclusions: The developed nomogram models provide a practical tool for the early identification of children at high risk of persistent diarrhea, facilitating intervention, potentially preventing serious sequelae, and improving the prognosis of children with S. typhimuriumenteritis.
Molecular Characterization of Vascular Plant Species from Antarctica (Deschampsia antarctica and Colobanthus quitensis) and Some Temperate and Tropical Cereal Crops Using Inter-Primer Binding Site (iPBS) Molecular Markers
Authors: GLEKU Olivet Delasi , SERCE Sedat 
Published: January 2024

Abstract
Antarctica vascular species are of vital importance for plant breeding and ecosystem studies due to their extreme environmental adaptabilities. However, limited molecular studies exist especially comparing Antarctica vascular species and other cereal species from the Poaceae family. In this study, the two vascular plant species; Deschampsia antarctica and Colobanthus quitensis found in the Antarctic ecosystem were molecularly characterized using 45 inter primer binding site (iPBS) retrotransposon markers. The Antarctica species were sampled from various locations in the Antarctica region during a scientific expedition. Five temperate cereal species; Avena sativa, Secale cereale, Hordeum vulgare, Triticum durum, and Triticum aestivum, and one tropical cereal species, Sorghum bicolor were also included for comparative analysis. A total of 23 individuals in two replicates all from the Poaceae family were assessed in this study. The iPBS markers produced 1506 scorable reproducible bands of which 1226 bands were polymorphic. The dendrogram based on the UPGMA clustering and principal coordinate analysis (PCoA) classified the speices into three distinct clusters. High variabilities existed between the Arctic, temperate and tropical species indicating their geographical diversity and adaptations. The results of the present study provides basis for further research on these species to identify sources of variation for climate resilience and resistance breeding for sustainable agriculture. Further study is recommended to assess the phylogenetic relationship among these species.
Access to optimal treatment of acute myeloid leukaemia patients is affected by sociodemographic factors: a French population based-study.
Authors: ATSOU Kueshivi Midodji , RACHET Bernard , MARINGE Camille , CORNET Edouard , CHRETIEN Marie-Lorraine , ROSSI Cédric , REMONTET Laurent , GIORGI Roch , GAUTHIER Sophie , GIRARD Stéphanie , BÖCKLE Johann , WASSE Stéphane Kroudia , RACHOU Helene , BOUZID Laila , PONCET Jean-Marc , ORAZIO Sébastien , MONNEREAU Alain , TROUSSARD Xavier , MAYNADIE Marc 
Published: January 2024

Abstract
Background
During their care pathway, AML patients not admitted to Specialized Haematology Units (SHU) have less access to curative treatment. We aim to determine whether access to optimal curative treatment is affected by sociodemographic factors.
Methods
We included 1,033 incidents AML-cases diagnosed between 2012–2016 from three French “départements”. We considered patients managed in reference hospitals SHU within 5 days(n = 297) received “gold-standard” treatment. Treatment was "curative-treatment” if intensive chemotherapy and “non-curative” otherwise. Firstly, we trained a Gradian Boosting Machine (GBM) algorithm on 80%(n = 238) of "gold-standard" cases to learn how they were treated and validated the model on the remaining 20%(n = 59). Next, GBM predictions were contrasted with actual treatment. Using multivariable logistic regression, we examined how non-optimal treatment (discrepancy between predicted curative and observed non-curative treatment) was associated with sociodemographic factors. Patients with predicted non-curative treatment were excluded as uninformative on access to curative treatment (n = 471).
Results
The rate of “curative treatment” was 84.8% (252/297) for gold-standard patients vs. 33.5% (247/736) for others. The three most influential predictive factors in gold-standard patients were age (68.3%-influence), t-AML/MDS (15.8%), and the AML-others subtypes (5.4%). A total of n = 102(9.9%) patients were in non-optimal treatments. Living in Basse-Normandie (0.65-times;95%CI [0.5,0.8]) and over 30minutes from a reference hospital were strongly associated with a non-optimal treatment.
Conclusions
There are geographical disparities in access to optimal treatment, potentially linked to medical desert situations or medical system organization.
‘It’s a rich people’s disease...’: Community perceptions about and responses to the coronavirus pandemic in Bangladesh
Authors: Sony M M Abdullah Al Mamun , Hasan Md Kamrul , Roy Tuhin , Basu Banga Kamal 
Published: January 2024

Abstract
The coronavirus pandemic has emerged as a major global social and health issue. A large body of research on this problem has largely been quantitative, epidemiological, and virological. There has been little exploration of how the general public frames this problem and how they respond to it. To address this gap, the purpose of this study is to explore community peoples' perceptions of and responses to the coronavirus pandemic within the existing sociocultural context of Bangladesh. A total of 46 semi structured interviews were conducted in a city and three remote villages located in the Khulna Division of Bangladesh in 2020. The interview transcripts were analyzed by applying Strong’s ideas about psychosocial responses to pandemics and the ‘risk’ theories of Ulrich Beck and Anthony Giddens. The findings showed that psychosocial responses included fear, anxiety, protective behaviors, excessive precautionary practices and widespread community-level stigma. These risk perceptions, as well as responses, were influenced by a wide variety of social, cultural, economic, educational, religious and locational factors. The findings will inform the development of more effective intervention programs by considering local cultural perceptions, beliefs and practices in relation to COVID-19.
Creating a Inexpensive, Effective Super Saturated Polymer Out of Citrus Polysaccharides
Authors: Rappoport Gray 
Published: January 2024

Abstract
The loss of water when farming constructs a significant environmental issue, as droughts evaporate 3o% to 75% of agriculturally used water. Retaining the water in the soil is an essential environmental act, as minimized water loss would occur, therefore acting against water depletion. The objective of this project was to create a cheap and yet effective super absorbent polymer from cross linked citrus polysaccharides, using both oranges and avocados.
I constructed a chemical system that allowed me to crosslink 17 oranges and 14 avocados through blending and a heating process of sitting in an oven for 180 degrees celsius for 20 minutes. Once the three built super absorbent polymers, and orange juice solution, an orange juice, orange peel, and avocado mixture, and a orange peel and avocado mixture were completed they were put into the soil boxes of 12 Ocimum Sanctum plants along with prebuilt super absorbent polymers acrylic, pectin, and starch. For 22 days a soil moisture meter was used to take samples of moisture from each of the soil boxes and a ruler was used to measure the plant’s height. Once found, the moisture levels, height, and number of leaves of each plant were placed into a data table on a macbook air, completing the experimental procedure.
The combined mixture of orange peels, orange juice, and avocado peels stayed above a moisture level of 8 for 17 days and gained 2.03 cm of height proving that it was the most effective super absorbent polymer. This critical result was then achieved as only four leaves were lost for 16 days of testing.
Creating a cheap yet effective superabsorbent polymer from crosslink citrus polysaccharides proved to be an effective objective and may change the future of farming.