bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2
Authors: Pastor-Alonso Oier , Syeda Zahra Anum , Kaske Bente , García-Moreno Fernando , Tetzlaff Felix , Bockelmann Enno , Grunwald Vanessa , Martín-Suárez Soraya , Riecken Kristoffer , Witte Otto Wilhelm , Encinas Juan Manuel , Urbach Anja 
Published: December 2023

AbstractLifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG). The mechanisms guiding transition of NSCs from the developmental to the adult state remain unclear. We show here, by using nestin-based reporter mice deficient for cyclin D2, that the aNSC pool is established through cyclin D2-dependent proliferation during the first two weeks of life. The absence of cyclin D2 does not affect normal development of the dentate gyrus until birth but prevents postnatal formation of radial glia-like aNSCs. Furthermore, retroviral fate mapping reveals that aNSCs are born on-site from precursors located in the dentate gyrus shortly after birth. Taken together, our data identify the critical time window and the spatial location of the precursor divisions that generate the persistent population of aNSCs and demonstrate the central role of cyclin D2 in this process.
Hotspot propensity across mutational processes
Authors: Arnedo-Pac Claudia , Muiños Ferran , Gonzalez-Perez Abel , Lopez-Bigas Nuria 
Published: December 2023

AbstractThe sparsity of mutations observed across tumours hinders our ability to study mutation rate variability at nucleotide resolution. To circumvent this, here we investigated the propensity of mutational processes to form mutational hotspots as a readout of their mutation rate variability at single base resolution. Mutational signatures 1 and 17 have the highest hotspot propensity (5–78 times higher than other processes). After accounting for trinucleotide mutational probabilities, sequence composition and mutational heterogeneity at 10 Kbp, most (94–95%) signature 17 hotspots remain unexplained, suggesting a significant role of local genomic features. For signature 1, the inclusion of genome-wide distribution of methylated CpG sites into models can explain most (80–100%) of the hotspot propensity. There is an increased hotspot propensity of signature 1 in normal tissues and de novo germline mutations. We demonstrate that hotspot propensity is a useful readout to assess the accuracy of mutation rate models at nucleotide resolution. This new approach and the findings derived from it open up new avenues for a range of somatic and germline studies investigating and modelling mutagenesis.
Cough: An Introductory Guide for Speech-Language Pathologists
Authors: Novaleski Carolyn K. , Near Lucille A. , Benzo Roberto P. 
Published: December 2023

Purpose:
The airway defense mechanism of cough is essential for human survival. Recognition is growing about the distinct role of speech-language pathologists in the nonpharmacological management of various cough disorders. This clinical focus article aims to deliver relevant education about normal and pathological cough to strengthen existing clinical knowledge and skills.

Conclusions:
The neuronal pathways underlying normal cough function are complex. Cough problems refer to either reduced or heightened cough stemming from various disease processes, and both clinical presentations have detrimental consequences. Current evidence supports that patients who suffer from cough dysfunction benefit from nonpharmacological interventions offered via speech therapy as an adjunct to medical treatments. Speech therapy strategies apply the higher cognitive components of cough by focusing on the deliberate modification and coordination of respiration. Future research priorities are positioned toward improving clinical outcomes for cough disorders.
Influence of protostellar outflows on star and protoplanetary disk formation in a massive star-forming clump
Authors: Lebreuilly U. , Hennebelle P. , Maury A. , González M. , Traficante A. , Klessen R. , Testi L. , Molinari S. 
Published: December 2023

Context. Due to the presence of magnetic fields, protostellar jets or outflows are a natural consequence of accretion onto protostars. They are expected to play an important role in star and protoplanetary disk formation.
Aims. We aim to determine the influence of outflows on star and protoplanetary disk formation in star-forming clumps.
Methods. Using RAMSES, we performed the first magnetohydrodynamics calculation of massive star-forming clumps with ambipolar diffusion; radiative transfer, including the radiative feedback of protostars; and protostellar outflows while systematically resolving the disk scales. We compared this simulation to a model without outflows.
Results. We found that protostellar outflows have a significant impact on both star and disk formation. They provide a significant amount of additional kinetic energy to the clump, with typical velocities of around a few 10 km s−1; impact the clump and disk temperatures; reduce the accretion rate onto the protostars; and enhance fragmentation in the filaments. We found that they promote a more numerous stellar population. They do not impact the low-mass end of the IMF much, which is probably controlled by the mass of the first Larson core; however, they have an influence on its peak and high-mass end.
Conclusions. Protostellar outflows appear to have a significant influence on both star and disk formation and should therefore be included in realistic simulations of star-forming environments.
Indoor Radon and Thoron Measurement using CR-39 and LR-115 detectors in dwellings of Beni Mellal-Khenifra area (Morocco)
Authors: Kayouh Noura , Rabi Rabi , Oufni Lhoucine 
Published: December 2023

Radon and thoron are radioactive gases that are found naturally in the environment. They can seep into homes through cracks in the foundation, walls, and floors. Once inside, they can build up to levels that are harmful to human health.
A study of radon and thoron concentrations in 65 homes in the Beni Mellal province of Morocco found that the levels varied widely, from 16 to 304 Bq.m-3 for radon and from 1 to 25 Bq.m-3 for thoron. The concentrations were found to be influenced by a number of factors, including the type of home, ventilation conditions, and the geological materials in the area. The average estimated dose received by the public due to radon and thoron in the homes studied was 45 ± 0.28 mSv.y-1 and 0.20 ± 0.01 mSv.y-1, respectively. These doses are considered to be low-level radiation exposure, but they can increase the risk of cancer over time. These results suggest that it would be beneficial to prohibit the construction of houses near industrial areas and to use construction materials that are adapted to the criteria of dose limitation.
Die Bedeutung spezifischer studienbedingter Anforderungen und
Ressourcen für die Gesundheit und Lebenszufriedenheit von
Studierenden
Authors: Hübner Liv , Girbig Maria , Gusy Burkhard , Lesener Tino , Seidler Andreas 
Published: December 2023

Zusammenfassung
Hintergrund Studien weisen auf einen Zusammenhang zwischen
Studienbedingungen und gesundheitlichen Beeinträchtigungen von
Studierenden hin. Ziel war die Untersuchung des Einflusses spezifischer
studienbezogener Anforderungen und Ressourcen auf die
selbsteingeschätzte Gesundheit.
Methode Studierende der Technischen Universität Dresden wurden
online zu ihrer Gesundheit und ihrem Studium befragt. Bezugnehmend auf das Study
Demands-Resources Modell wurden deskriptive und Zusammenhangsanalysen
durchgeführt.
Ergebnisse 1.312 Studierende wurden in die Untersuchungen einbezogen. Ca.
ein Fünftel der Teilnehmenden gab eine geringe Lebenszufriedenheit und
hohe Erschöpfung an. Zeitliche und geistige Anforderungen sind mit einer
schlechteren Gesundheit, soziale Unterstützung und Zeitspielraum im
Studium mit einer besseren Gesundheit verbunden. Dies wurde besonders bei einer
Kombination von hohen Anforderungen und geringen Ressourcen deutlich.
Schlussfolgerung Die Ergebnisse liefern Ansatzpunkte für
präventive Maßnahmen zur Stärkung der studentischen
Gesundheit.
Prenatal Detection and Postnatal Outcome of Persistent Left Superior
Vena Cava and Agenesis of Ductus Venosus Associated with Postnatal Bovine Aortic
Arch
Authors: Elbistanli Ceylin , Yozgat Yılmaz , Dogan Mehmet Said , Yozgat Can Yilmaz , Kütük Mehmet Serdar 
Published: December 2023

Abstract
Background Isolated agenesis of ductus venosus (ADV) is usually a benign
condition, but it may be associated with cardiovascular defects, hydrops, growth
restriction, and chromosomal abnormalities. Additionally, persistent left
superior vena cava (PLSVC) and bovine aortic arch are relatively common fetal
anomalies. To the author’s knowledge, this is the first report of
prenatal detection of DV agenesis and PLSVC associated with the postnatal bovine
aortic arch with a hypoplastic transverse aortic arch.
Case A 25-year-old, G2P1 woman was referred to our department at 31 weeks
due to fetal growth restriction and short femur. On fetal echocardiography, DV
could not be viewed via two-dimensional (2D) and Doppler ultrasound (US)
imaging; there was also evidence of the co-occurrence of PLSVC and an aortic
arch anomaly. We revealed the intrahepatic continuation of the umbilical vein. A
weekly follow-up program was scheduled for the patient and the rest of the
pregnancy was uneventful. Postnatal, thorax computer tomography and
transthoracic echocardiography (TTE) demonstrated PLSVC and bovine aortic arch
associated with hypoplastic transverse aortic arch. Routine echocardiographic
examinations revealed that the blood flow of the aortic arch had increased
gradually, and the male infant’s aortic arch had significantly widened
and reached the normal range until the baby was discharged from the
hospital.
Conclusion DV agenesis and PLSVC are usually benign conditions but
underlying serious heart diseases may accompany them. Therefore, in situations
like ours, a prenatal aortic arch evaluation is of capital importance. Postnatal
hemodynamic changes should be taken into consideration in the management of
these cases. This is the first example in the literature that these
abnormalities co-existed in one case.
Effectiveness of Neuropediatric Inpatient Rehabilitation
Authors: Stadler Hannah , Müller Kristina , Kurlemann Gerhard , Lendt Michael 
Published: December 2023

Abstract
Aim Inpatient rehabilitation plays an important role in treating neurological diseases in children and adolescents. However, there is a lack of current research concerning this matter. This retrospective study aims to analyze the effectiveness of neuropediatric inpatient rehabilitation, to identify influencing factors, and to examine the importance of inpatient rehabilitation programs.
Methods We reviewed medical records of patients, diagnosed with cerebral palsy, traumatic brain injury (TBI), or stroke who had an inpatient rehabilitation at the Department of Neuropediatrics of St. Mauritius Therapieklinik in Meerbusch from 2012 to 2019. The patients received several units of different therapies such as motor and cognitive rehabilitation or speech therapy per day, depending on their individual needs and aims. Rehabilitation outcome was assessed by comparing Gross Motor Function Measure-88 and Pediatric Evaluation of Disability Inventory admission and discharge scores. Influences of sex, age, length of stay (LOS), and admission score were analyzed.
Results A total of 738 patients with a mean age of 9.2 (± 5.1) years and a mean LOS of 53.8 (± 33.7) days were included; 38.5% were female. Patients, regardless of their diagnosis, sex, or age, demonstrated highly significant and meaningful improvements of self-care, mobility, and social function during inpatient rehabilitation. Especially, the group of patients with TBI and stroke could approximate their skills substantially to the ones of healthy peers. A longer LOS correlated significantly with greater improvement of skills.
Interpretation This is a current study, supporting the effectiveness of neuropediatric inpatient rehabilitation and affirming its value in treating neurological diseases in children and adolescents.
The internationalization of state-owned enterprises in liberalized markets: the role of home-country pro-market reforms
Authors: Santangelo Grazia D. , Symeou Pavlos C. 
Published: December 2023

AbstractWe study how home-country factors can alter the impact of host-country conditions on the location decisions of state-owned enterprises (SOEs). Specifically, we examine the role of home-country pro-market reforms in facilitating SOEs’ entry into host countries with a free-market logic. We consider two types of home-country pro-market reforms: market liberalization and privatization. We propose that home market liberalization mainly mitigates SOEs’ market legitimacy deficit and facilitates their entry into host countries with a prominent free-market logic. In such contexts, businesses perceive SOEs from more liberalized home markets as more accustomed to market competition and thus are less likely to exert pressure on the host government against them. We also argue that furthering SOEs’ privatization mitigates SOEs’ political legitimacy deficit in host countries with a free-market logic, thus facilitating entry. In these contexts, host governments perceive more privatized SOEs as more independent from their home state due to reduced political connections. We find support for our arguments in a dataset of 97 telecom SOEs from 97 countries over the period 1990–2010. Our study advances research on SOEs’ internationalization and research on pro-market reforms and has relevant implications for managers and policymakers.
An investigation of selected UTAUT constructs and consumption values of Gen Z and Gen X for mobile banking services and behavioral intentions to facilitate the adoption of mobile apps
Authors: Dendrinos Konstantinos , Spais George 
Published: December 2023

AbstractThis study aims to analyze the impact of consumption values on the adoption of NBG’s mobile banking services and the role of customers’ motivation and app adoption in this process. The study reveals users’ attitudes and behavior towards mobile banking by establishing significant connections between selected UTAUT constructs. Based on a critical case of the m-banking services of a leading Greek financial institution, we gathered 418 full-answered questionnaires from a convenience sample of 654 customers to test 18 research hypotheses. The research results confirm that the three selected UTAUT constructs, are antecedents of behavioral intention, supporting the initial assumption. This study analyzes the factors that drive the adoption and usage of mobile banking apps, providing valuable insights for marketing academia and managers.
A low-frequency normal conducting cavity with higher-order mode damping for fourth-generation synchrotron radiation sources
Authors: Zhu Jun-Yu , Li Xiao , Yu Jie-Bing , Lu Zhi-Jun , Zhang Chun-Lin , Long Wei , Chen Sheng-Yi , Liu Yang , Liu Sheng-Hua , Wu Bin , Li Xiang , Wu Jian 
Published: December 2023

The utilization of a low-frequency (&lt;200 MHz) RF system in storage facilitates the attainment of ultra-low emittances in synchrotron light sources through on-axis injection. This paper focuses on the development of a low-frequency normal conducting (NC) cavity with higher-order mode (HOM) damping for fourth-generation synchrotron light sources. We propose a novel approach to achieve efficient HOM damping in a NC cavity by optimizing the lowest frequency HOM and implementing a beam-line absorber. Notably, unlike conventional NC cavities, the presence of a large beam tube for the beam-line absorber does not compromise the accelerating performance in a coaxial resonant cavity, enabling effective HOM damping while maintaining a high shunt impedance. Through simulations, the prototype design of a 166.6 MHz HOM-damped cavity demonstrates a fundamental mode impedance of ∼8 MΩ, with longitudinal and transverse HOM impedances below 2.0 and 50 kΩ/m, respectively.
Low-temperature trapping of N2 reduction reaction intermediates in nitrogenase MoFe protein–CdS quantum dot complexes
Authors: Pellows Lauren M. , Vansuch Gregory E. , Chica Bryant , Yang Zhi-Yong , Ruzicka Jesse L. , Willis Mark A. , Clinger Andrew , Brown Katherine A. , Seefeldt Lance C. , Peters John W. , Dukovic Gordana , Mulder David W. , King Paul W. 
Published: December 2023

The biological reduction of N2 to ammonia requires the ATP-dependent, sequential delivery of electrons from the Fe protein to the MoFe protein of nitrogenase. It has been demonstrated that CdS nanocrystals can replace the Fe protein to deliver photoexcited electrons to the MoFe protein. Herein, light-activated electron delivery within the CdS:MoFe protein complex was achieved in the frozen state, revealing that all the electron paramagnetic resonance (EPR) active E-state intermediates in the catalytic cycle can be trapped and characterized by EPR spectroscopy. Prior to illumination, the CdS:MoFe protein complex EPR spectrum was composed of a S = 3/2 rhombic signal (g = 4.33, 3.63, and 2.01) consistent with the FeMo-cofactor in the resting state, E0. Illumination for sequential 1-h periods at 233 K under 1 atm of N2 led to a cumulative attenuation of E0 by 75%. This coincided with the appearance of S = 3/2 and S = 1/2 signals assigned to two-electron (E2) and four-electron (E4) reduced states of the FeMo-cofactor, together with additional S = 1/2 signals consistent with the formation of E6 and E8 states. Simulations of EPR spectra allowed quantification of the different E-state populations, along with mapping of these populations onto the Lowe–Thorneley kinetic scheme. The outcome of this work demonstrates that the photochemical delivery of electrons to the MoFe protein can be used to populate all of the EPR active E-state intermediates of the nitrogenase MoFe protein cycle.
Development of a pulse modulated sub-radio frequency power supply for atmospheric pressure plasma devices
Authors: Mallick Aishik Basu , Prakash G. Veda , Kar Satyananda , Narayanan Ramesh 
Published: December 2023

The effect of pulse-modulated sub-RF range (100 kHz–1 MHz) excitation on atmospheric pressure argon plasma jet characteristics is studied. For this, a suitable power supply is developed, offering a sub-µs rise time with control of different parameters, such as voltage amplitude, pulse modulation frequency in the range of 1–30 kHz, and an oscillation frequency of ∼520 kHz, which can affect the plasma behavior. Plasma characteristics, such as reactive species generation, ionic composition, plasma plume length, and gas temperature, are evaluated qualitatively and quantitatively by employing diagnostics such as optical emission spectroscopy, molecular beam mass spectrometry, and optical imaging. Experimental observations indicate that the gas temperature of the plasma jet and plume length increase with the applied voltage for all pulse modulation frequencies, with a maximum value of ∼(325 ± 2 K) and a maximum length of ∼(23 ± 3 mm), respectively, at 30 kHz and 9 kVpp. The emission intensities of OH• and O• lines show an incremental behavior with the applied voltage across all pulse modulation frequencies. The relative yield of different positive (OH+, O+, etc.) and negative (OH−, O−, etc.) ions also increases with the applied voltage for all pulse modulation frequencies with maximum values of ∼(7.6%, 9.9%) and (3.9%, 9.4%), respectively; these are relatively close to RF excited ionic concentrations reported previously. Attaining a high plasma length and species yield signify the features of both kHz and RF atmospheric plasmas. This study offers significant insights and flexibility into exploring the impact of different RF frequency regimes on plasma characteristics.
Durum wheat (Triticum turgidum L. var. durum Desf.) landraces and their potential for enhancing agro-physiological characteristics and stability performance in breeding programs
Authors: Mohammadi Reza , Cheghamirza Kianoosh , Geravandi Mahdi , Zarei Leila 
Published: December 2023

Context Landraces are a potential source of genetic diversity and provide useful genetic resources to cope with the current and future challenges in crop breeding. Aims The main objectives of this study were to identify superior landraces with good levels of agro-physiological traits, and high mean yield and stability performance. Methods We evaluated a worldwide diversity panel of 196 durum wheat accessions originating from Iran and 17 other different countries along with four check varieties using an alpha-lattice design with two replications under drought and irrigated conditions in two cropping seasons. Key results The results showed that the variance due to genotype and environment for all measured traits; and genotype-by-environment interaction for grain yield were significant (P < 0.01). The genotype-by-traits (GT) biplot analysis revealed that the relationships of traits with grain yield were affected by environment, but some consistent correlations among studied traits were observed. Chlorophyll content, earliness and 1000-kernel weight positively correlated with mean yield under drought condition, whereas greenness index, plant height, days to heading and maturity positively correlated with yield under irrigated condition. The results verified that clustering pattern of durum diversity panel did not follow the grouping of accessions according to their geographic origins. Using the genotype plus genotype-by-environment (GGE) biplot method, accessions with high yield and stability performance were identified. Conclusions The results provide the possibility to select a subset of best accessions based on the traits studied, for further evaluations under drought and irrigated conditions. Implications The findings are useful for selective breeding for specific traits as well as for enhancing the genetic basis of the durum wheat breeding program.