bluuebunny/crossref_metadata_2025_split huggingface dataset:
O USO DA FONOFORESE EM DOENÇAS DO SISTEMA MUSCULOSQUELÉTICO
Authors: Cunha Hortêncio Marco Antônio 
Published: January 2024

Introdução: O uso do ultrassom (US) em diferentes aplicações na área da saúde tem ganhado destaque, devido ao fato do US poder ser usado como fonte de energia para a ocorrência de reações químicas. O US apresenta diferentes formas de uso, nas mais variadas frequências, sendo que na área da fisioterapia seu uso ocorre nas frequências de 1 e 3 MHz. Na fisioterapia, o ultrassom terapêutico consiste na utilização do aparelho para efeitos térmicos na região que necessita de tratamento: redução da dor, redução de espasmos musculares, aumento da extensibilidade tecidual e melhora do fluxo sanguíneo local. A fonoforese é uma técnica que facilita a penetração cutânea através da energia ultrassônica na desorganização da estrutura lipídica da epiderme, utilizando como meio de contato entre o cabeçote do aparelho e a pele com medicamento. O objetivo do presente estudo é investigar e evidenciar o efeito da utilização da fonoforese em alterações musculoesqueléticas. Métodos: Resultados:dos resultados e desfechos dos estudos escolhidos, observou-se que a maioria desses estudos utiliza desfechos semelhantes. Como resultado, em síntese, a maioria dos estudos concluiu que o uso da fonoforese foi eficaz para os desfechos avaliados, em curto prazo, e principalmente que esse tratamento foi eficaz, facilitando a redução da inflamação e da dor e das alterações musculoesqueléticas. Conclusão: Todos os estudos demonstraram efeito positivo da fonoforese no alívio da dor, redução da rigidez articular, melhora da capacidade funcional e função física nos distúrbios musculoesqueléticos.
Palavras-chave: Ultrassom terapêutico, fisioterapia, fonoforese,sistema musculoesquelético.
The Potential Place of Tabii in Global Competition: What Do Story Structures Tell Us?
Authors: ÇELİK Kemal 
Published: January 2024

This article focuses on TRT's (Turkish Radio and Television Corporation) digital platform called "Tabii," which was launched in 2023. Tabii is a platform constructed with state support during a time when it is becoming progressively challenging to individually counter global content monopolies such as Netflix and Disney. Tabii embraces a kind of eastern tradition and internalizes the values of Turkish Islamic thought under the slogan of "stories that unite us." With this approach, Tabii seeks to challenge the previously established and dominant digital platforms or create an alternative space. It is evident that such an endeavor is quite challenging.
In this research, focusing on loglines and story structures, the themes and character depth of the series are evaluated. For the purpose of sampling, the 10 most-watched series on the Tabii platform were selected, and their story structures and themes were subjected to structural analysis. In conclusion of this analysis, while Tabii's targeted broadcasting approach and advocated human values are deemed significant, the narrative sentences and story structures employed for their conveyance have been found to be weak. Hence, this article highlights the importance of Tabii platform in the context of communication and content creation in the digital world, emphasizing the potential for conveying their messages more effectively with stronger story structures.
Imaging Upper-Mantle Anisotropy with Transdimensional Bayesian Monte Carlo Sampling
Authors: Del Piccolo Gianmarco , VanderBeek Brandon P. , Faccenda Manuele , Morelli Andrea , Byrnes Joseph S. 
Published: January 2024

ABSTRACT
Underdetermination is a condition affecting all problems in seismic imaging. It manifests mainly in the nonuniqueness of the models inferred from the data. This condition is exacerbated if simplifying hypotheses like isotropy are discarded in favor of more realistic anisotropic models that, although supported by seismological evidence, require more free parameters. Investigating the connections between underdetermination and anisotropy requires the implementation of solvers which explore the whole family of possibilities behind nonuniqueness and allow for more informed conclusions about the interpretation of the seismic models. Because these aspects cannot be investigated using traditional iterative linearized inversion schemes with regularization constraints that collapse the infinite possible models into a unique solution, we explore the application of transdimensional Bayesian Monte Carlo sampling to address the consequences of underdetermination in anisotropic seismic imaging. We show how teleseismic waves of P and S phases can constrain upper-mantle anisotropy and the amount of additional information these data provide in terms of uncertainty and trade-offs among multiple fields.
Operational Earthquake Forecasting in Japan: A Study of Municipal Government Planning for an Earthquake Advisory or Warning in the Nankai Region
Authors: Goltz James D. , Yamori Katsuya , Nakayachi Kazuya , Shiroshita Hideyuki , Sugiyama Takashi , Matsubara Yu 
Published: January 2024

Abstract
A team of social scientists from the United States and Japan has conducted a study exploring the extent to which municipal governments in Japan have developed plans for response to an operational earthquake forecast from the Japan Meteorological Agency (JMA), indicating that seismic activity in the Nankai trough region has elevated the short-term probability that a major earthquake may occur. Employing both survey research and in-depth interviews, the team explored various aspects of the history and science behind the alerting system, guidance from the national government of Japan, and planning by local jurisdictions for a possible future Nankai trough major earthquake. The survey included questions regarding planning actions included in response plans for receipt of “special earthquake warning information” as well as questions regarding challenges in the planning process, expectations that an earthquake would follow the issuance of an alert, and whether planning would reduce the number of fatalities and injuries. We also conducted in-depth interviews that explored the scientific basis for the alerting system and asked working disaster managers in the Nankai region what they had done to plan and the reasons for not planning if plans had not been developed. We received 469 responses from a total of 736 jurisdictions that comprise the Nankai region—a response rate of 63.7%. We conducted a total of 17 in-depth interviews. In general, we found that a majority of jurisdictions have response plans for receipt of an alert from the JMA; however, the plans lacked a number of planning elements considered important from a disaster management perspective. In addition, many smaller jurisdictions lacked the staffing, resources, and guidance to form comprehensive response plans. Our report identifies both the strengths and weaknesses of existing plans, and outlines a program for improving planning in the region.
The utility of colposcopy in detecting relapse after treatment of gynaecological malignancies
Authors: Joseph Anu N. , Sreedharan Sabarinath Panthrandil , Davis Nila Theresa 
Published: January 2024

Background: Vaginal bleeding is the most common symptom of vault relapse in gynecological cancers. This symptom may be overlooked or attributed to other causes, such as atrophy, infection, or post-radiation changes. Colposcopy allows direct magnified visualization of vaginal mucosa and abnormal vasculature though its role in detecting relapse is unclear.
Methods: It is a retrospective observational study of 31 patients who were referred for colposcopy and biopsy with complaints of abnormal vaginal bleeding during follow up of endometrial or cervical cancer.
Results: Among 31 patients, 19 patients were diagnosed to have primary cervical cancer and 12 endometrial cancers. Primary treatment was surgery alone (n=10, 32.2%), chemo-radiation alone (n=4, 12.9%) and both (n=17, 54.8%). Abnormal colposcopic findings were atropic features (n=21, 67.7%), radiation changes (n=8, 25.8%), erosion (n=9, 29.0%), acetowhite areas (n=9, 29.0%), abnormal vessels (n=8, 25.8%) and iodine staining abnormality (n=16, 51.6%). According to Swede scoring system, 77.1% (n=24) were normal or low grade lesions, 22.6% (n=7) were high grade lesions. Total of 6 recurrence cases identified out of which 5 cases had high grade (Swede score >7) and one had low grade (Swede score 5-7) colposcopic features. On taking Swede score cut off of 5 or more, the sensitivity of colposcopy in detecting vault recurrence is 100%, specificity 96%, positive likelihood ratio of 25%and negative likelihood ratio of 0%. Overall the accuracy of colposcopy in detecting relapse was 96.8%.
Conclusions: In our experience colposcopy is worth in detecting the cause of abnormal vaginal bleeding after treatment for endometrial and cervical cancer. Swede score is a good measure to decide on taking biopsy among these patients. Furthermore, larger studies are needed for better clarification.
Neonatal birth weight as a predictor of mode of delivery in singleton term pregnancies at a tertiary level maternity hospital in Urban Mumbai
Authors: Upadhyay Dishant , Palve Tushar , Fatemi Sakina , Raza Sameen 
Published: January 2024

Background: Mode of delivery is determined by a variety of feto-maternal factors like fetal presentation, maternal age, parity as well as environmental factors such as place of residence, quality of ANC care etc. Aim was to assess if neonatal birth wight (NBW) affected the mode of delivery at a tertiary level maternity hospital in urban Mumbai.
Methods: Ours was an observational study having cross sectional design, utilizing data retrieved from hospital records, conducted at Cama and Albless Hospital in Mumbai over 3 months- July 2023 -September 2023. Data regarding maternal parity, age, mode of delivery and neonatal birth weight was compiled in Microsoft Excel 2017 from hospital records after taking Ethics Committee permission for the same.
Results: In n=104 live viable term singleton pregnancies observed over 3 months LSCS rate of 25.96% was observed, higher Neonatal birth weight (NBW) was associated with caesarean delivery. 89% of the underweight neonates (<2.5kg) delivered vaginally while 100% of the macrocosmic neonates (>4kg) were delivered by LSCS. Maternal age correlated positively with neonatal weight and parity. Neonatal sex was not associated with mode of delivery or NBW.
Conclusions: Mode of delivery is affected by NBW, but not by maternal age or neonatal sex. Mode of delivery in first pregnancy significantly determines mode of delivery in subsequent pregnancies.
A study on delayed cord clamping and early skin-to-skin contact and its effects on neonatal outcome
Authors: Nee Laxmi Sharma Laxmi Dixit , Gayadin Yadav Sushilkumar , Sangeeta Kansal  , Sinha Shuchi Jain , Jain Madhu 
Published: January 2024

Background: Previous study conducted against immediate tying and cutting of the umbilical cord and suggested waiting until the child had taken repeated breaths and the pulsation in the cord had ceased to prevent potential weakness in the child. A comparative study between delayed cord clamping (DCC) and early cord clamping (ECC) was carried out on a select group of primigravida without any high-risk factor and delivering at term. The objective of the study was to identify the effects of delayed cord clamping and early skin to skin contact on new born infant’s physiological parameters (temperature, weight, SpO2= saturation of peripheral oxygen, Apgar score= appearance, pulse, grimace, activity, and respiration, Hb=haemoglobin level).
Methods: Study sample consisted of 300 mothers and their new born after gaining mother’s acceptance. They were divided into 2 groups of 150 each. Group A underwent delayed cord clamping and early skin to skin contact and group B early cord clamping. Newborns monitored 24 hours for hypothermia, apnoea, oxygen needs.
Results: The findings of the present study were equivalent among both groups regards the mean neonatal haematological parameters were comparable and slightly elevated hemoglobin level and weight status among late cord clamping compared to early cord clamping group with significant difference was observed at 24 hour later.
Conclusions: This study was found that DCC does have a beneficial effect on temperature, Apgar score, SpO2, Hb level and weight status of new born. Therefore, it is believed that DCC and early skin to skin contact (ESSC) provides effective thermal control with a reduced risk of hypothermia.
Developing an Effective Team-Based Emergency Training Program for Medical Students
Authors: Hartono Pinter , Adiyanto Bowo , Nur Rifdhani Fakhrudin , Ancilla Cornelia , Rahma Aulia Zuhria 
Published: January 2024

Introduction: Team-based patient management in critical care demands a knowledgeable, skillful, and responsive doctor who collaborates well on teams. Medical education is responsible for producing competent graduates who meet the above requirements. However, the current medical curriculum in Indonesia tends to focus only on individual knowledge and appraisal. There was no standardized university-based group emergency training and examination with comprehensive emergency topics beyond cardiac and trauma cases. Objective: This study aimed to develop and evaluate a team-based emergency training program that enhances medical students' preparedness and teamwork skills in dealing with future emergencies in the workplace. Materials and Methods: We developed Acute Life Threatening Events Management (ALTEM), a three-day emergency training program consisting of pre-test, lectures, guided skill practice, group (case-based) simulation exam, and post-test. Group simulation occurred in a virtual hospital with high-fidelity mannequins, actual medical equipment (i.e., beds, monitors, drugs, tools, pads), two-way mirror rooms, and simulated patient family to resemble real hospital situations. The program was then evaluated by a modified Kirkpatrick evaluation model, which measures individual perception, satisfaction, understanding, and performance related to the program. Results: A total of 114 participants were involved in this study. Most subjects (>80%) had a good experience with the program. ALTEM training program significantly increased communication and teamwork (p <0.001) and decision-making towards critical patients (p <0.001) in the univariate analysis. Communication and teamwork remained related considerably in the multivariate analysis (aOR 7.866; p = 0.005). Conclusion: The ALTEM simulation program obtained a good response from the subjects and was a prospective program to improve medical students' competence and teamwork skills in emergencies.
Mathematical modeling of physiological parameters in traumatic shock caused by lower limb blast injury
Authors: Tolmachev I. V. , Anisin A. V. , Bala A. M. , Vrazhnov D. A. , Shapovalov A. V. , Kotlovskiy M. Yu. , Laptev V. V. , Brazovskiy K. S. 
Published: January 2024

The aim of this study was to apply integrative physiological mathematical models to simulate physiological parameters in traumatic shock caused by lower limb blast injury.Materials and methods. At the first stage of mathematical modeling, we applied lumped parameter integrative physiological models, and at the second stage we used neural networks.Results. We developed a clinical decision support system that allows to determine the intensity of blood loss in lower limb blast injuries according to physiological monitoring data.Conclusion. The developed approaches make it possible to partially solve the problem associated with the impossibility of accumulating a sufficient amount of medical data for a specific person to create an adequate personalized clinical decision support system.
A method to evaluate the functional state of the human brain after acute in-hospital stroke
Authors: Brazovskii K. S. , Vinokurova D. A. , Strezh V. A. , Ussov V. Yu. 
Published: January 2024

Acute in-hospital stroke is a severe complication of the early recovery period after cardiovascular surgery with a probability of up to 15%. Unfortunately, in-time diagnostic neuroimaging (computed tomography and magnetic resonance imaging) in cases of severe brain damages is considerably hindered increasing the risk of an adverse outcome.The aim of the study was to develop a method to evaluate the functional state of the human brain in patients with severe in-hospital stroke measuring parameters of electrical activity in the central nervous system.Materials and methods. The sample was composed of 20 anonymous archived electroencephalograms obtained from volunteers with no neurological disorders, 10 records of patients without neurological symptoms during general anesthesia, 17 records of patients with out-of-hospital strokes obtained from the UCLH Stroke EIT Dataset, and 18 records from patients with acute in-hospital stroke during neuromonitoring in the early postoperative recovery period. A new integral coefficient of the functional state was introduced, and an algorithm to calculate the proposed measure of the functional activity of the central nervous system was developed and implemented.Results. The proposed method to evaluate the functional state of the human brain was applied to analyze neurophysiological records obtained from people with different activity of the nervous system: from resting state to deep coma. It was shown that the integral coefficient naturally reflects the functional state of the human brain and can be used for early detection of brain dysfunction and damages caused by cerebral hemodynamic impairment.Conclusion. The introduced integral criterion to evaluate the functional state of the human brain can be used for long-term postoperative monitoring in cardiac patients who underwent surgical treatment.
Adipokine imbalance and its role in the pathogenesis of novel coronavirus infection
Authors: Bespalova I. D. , Mitrichenko U. M. , Kalyuzhin V. V. , Koroleva E. S. , Koshchavtseva Yu. I. , Romanov D. S. , Pershina D. E. 
Published: January 2024

The review summarizes and analyzes the results of major foreign studies on the role of adipokine imbalance in the development of a severe course and complications of novel coronavirus infection (COVID-19). Adipokines are biologically active compounds produced by adipose tissue cells and involved in the regulation of metabolism and the functioning of the immune system. Obesity is a proven risk factor for severe COVID-19 due to high hormonal and metabolic activity of visceral adipose tissue. A deep understanding of COVID-19 pathogenesis from the point of view of the role of adipokine imbalance in it can provide the grounds for the development of effective pathogenetic approaches to the prevention of a severe course and complications of novel coronavirus infection.
Prediction of a poor ovarian response in assisted reproductive technology programs in patients after surgical interventions on the ovaries
Authors: Dmitrieva M. L. , Petrov I. A. , Tikhonovskaya O. A. , Logvinov S. V. , Duma O. M. , Kosimova Z. O. , Chernyshova M. A. , Yuriev S. Y. , Timofeeva O. S. , Zhdankina A. A. , Gerasimov A. V. 
Published: January 2024

The aim. To conduct a comparative analysis of clinical and anamnestic data in women of reproductive age after ovarian cyst surgery and with occult premature ovarian insufficiency (POI) to predict a poor ovarian response to stimulation.Materials and methods. We conducted a retrospective study of medical records of women (aged 18–40 years) with infertility at the Assisted Reproductive Technology Center of Siberian State Medical University from 2017 to 2020. The main group consisted of 84 patients who underwent ovarian cyst surgery. The comparison group consisted of 33 patients with biochemical signs of POI (follicle stimulating hormone (FSH) 10–12 mMU / ml) who did not undergo ovarian cyst surgery. Anti-Mullerian hormone (AMH), FSH, estradiol, the antral follicle count (AFC), and the ovarian response to stimulation were compared.Results. A correlation was established between AFC and a poor ovarian response both in the main group (r = –0.7; p = 0.004) and in the comparison group (r = –0.620; p = 0.000) in women under 35 years of age. A correlation was found between the concentration of estradiol and a poor ovarian response in the comparison group in women over 35 years of age (r = –0.707; p = 0.001). A moderate negative correlation between AMH and a poor ovarian response was revealed only in the main group of women under the age of 35 years (r = –0.589; p = 0.021). A moderate negative correlation between AMH and a poor ovarian response was revealed in the comparison group in women under the age of 35 years (r = –0.648; p = 0.000), a weak negative correlation was found for women at the age of 35 years (r = –0.500; p = 0.004). In both groups, the level of FSH did not determine the ovarian response to stimulation.Conclusion. The determination of AFC and AMH is more significant in predicting a poor ovarian response in women after ovarian surgery and in women with occult signs of POI under the age of 35 years, compared with FSH. In the group of women over 35 years with occult signs of POI, the concentration of estradiol may matter in predicting a poor ovarian response, which requires further research.
Epithelial – mesenchymal transition markers, proliferation markers, and cytokine secretion in breast tissue in malignant and benign breast diseases
Authors: Autenshlyus A. I. , Arkhipov S. A. , Mikhaylova E. S. , Arkhipova V. V. , Proskura A. V. , Varaksin N. A. , Lyahovich V. V. 
Published: January 2024

Aim. To develop methodological grounds for assessing the probability of breast malignancy in patients with noncancerous breast diseases (NCBD) by the following parameters: expression of markers of epithelial – mesenchymal transition (EMT) and proliferation and production of cytokines by samples of the breast tissue.Materials and methods. In breast samples (BS) of patients with invasive carcinoma of no special type (ICNT) and patients with NCBD, immunohistochemistry was used to determine the expression of E-cadherin (CDH1), integrin β1 (CD29), type II collagen (CII), and proliferation of Ki-67. Using the enzyme-linked immunosorbent assay, concentrations of interleukin (IL)-2, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, tumor necrosis factor (TNF)α, interferon (IFN)γ, granulocyte colony-stimulating factor (G-CSF), granulocyte – macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF)-A, and monocyte chemoattractant protein (MCP)-1 were determined in the supernatant of the cultured breast tissue samples.Results. It was shown that ICNT and NCBD differ in the expression of E-cadherin, CD29, Ki-67, and the production of IL-2, IL-4, IL-6, IL-17, IL-18, IL-1Ra, TNFα, IFNγ, and MCP-1. The ROC analysis found that the models characterizing the differences between the ICNT and NCBD samples were formed by the parameters of CD29 and Ki-67 expression and IL-17, IL-18, TNFα, VEGF-A, and MCP1 production. The neural network analysis revealed that CD29, IL-1Ra, TNFα, and VEGF-A had the greatest normalized importance for assessing the differences between the ICNT and NCBD samples. Clustering of the combined database of patients with NCBD and ICNT by the expression of E-cadherin, CD29, Ki-67 and by the production of IL-17, IL-18, TNFα, MCP-1, and VEGF-A resulted in a cluster which includes the parameters of 94.1% of patients with NCBD. The parameters of less than 10% of patients with NCBD who fell into other clusters practically coincided with the studied parameters of the ICNT group, which suggests that these patients may form a risk group with the malignancy probability of more than 90%.Conclusion. The data obtained made it possible to develop methodological grounds for assessing the likelihood of breast malignancy in patients with NCBD.