bluuebunny/crossref_metadata_2025_split huggingface dataset:
Andrographolide inhibits Burkitt’s lymphoma by binding JUN and CASP3 proteins
Authors: Zeng Junquan , Zheng Yongliang , Dong Si , Ding Ting , Zhang Shouhua , Li Kuangfan , Liu Haiyun , Fang Quangang , Yuan Sheng , Wei Yujing , Li Jing , Liu Tingting 
Published: December 2023

Abstract
Background
Burkitt’s lymphoma, one of the most common subtypes of pediatric malignant lymphoma, is notorious for its swift onset, aggressive proliferation, pronounced invasiveness, and marked malignancy. The therapeutic landscape for Burkitt’s lymphoma currently falls short of providing universally effective and tolerable solutions. Andrographolide, a primary active component of Andrographis paniculata, is renowned for its properties of heat-clearing, detoxification, inflammation reduction, and pain relief. It is predominantly used in treating bacterial and viral infections of the upper respiratory tract, as well as dysentery. Various reports highlight the antitumor effects of andrographolide. Yet, its specific impact and the underlying mechanism of action on Burkitt’s lymphoma remain an uncharted area of research.

Method
We employed network pharmacology to pinpoint the targets of andrographolide’s action on Burkitt’s lymphoma and the associated pathways. We then evaluated the impact of andrographolide on Burkitt’s lymphoma using both in vitro and in vivo patient-derived xenograft (PDX) models. Concurrently, we confirmed the molecular targets of andrographolide in Burkitt’s lymphoma through immunofluorescence assays.

Result
Utilizing network pharmacology, we identified 15 relevant targets, 60 interrelationships between these targets, and numerous associated signaling pathways for andrographolide’s action on Burkitt’s lymphoma. In vitro efficacy tests using High-throughput Drug Sensitivity Testing and in vivo PDX model evaluations revealed that andrographolide effectively curtailed the growth of Burkitt’s lymphoma. Moreover, we observed a increased in the expression of JUN (c-Jun) and CASP3 (Caspase 3) proteins in Burkitt’s lymphoma cells treated with andrographolide.

Conclusion
Andrographolide inhibits the growth of Burkitt’s lymphoma by inhibiting JUN and CASP3 proteins.
Cytotoxic lesions of the corpus callosum: a systematic review
Authors: Moors Selina , Nakhostin Dominik , Ilchenko Dariya , Kulcsar Zsolt , Starkey Jay , Winklhofer Sebastian , Ineichen Benjamin V. 
Published: December 2023

Abstract
Objectives
Cytotoxic lesions of the corpus callosum (CLOCC) are a common magnetic resonance imaging (MRI) finding associated with various systemic diseases including COVID-19. Although an increasing number of such cases is reported in the literature, there is a lack of systematic evidence summarizing the etiology and neuroimaging findings of these lesions. Thus, the aim of this systematic review was to synthesize the applied nomenclature, neuroimaging and clinical features, and differential diagnoses as well as associated disease entities of CLOCC.

Materials and methods
A comprehensive literature search in three biomedical databases identified 441 references, out of which 324 were eligible for a narrative summary including a total of 1353 patients.

Results
Our PRISMA-conform systematic review identifies a broad panel of disease entities which are associated with CLOCC, among them toxic/drug-treatment-associated, infectious (viral, bacterial), vascular, metabolic, traumatic, and neoplastic entities in both adult and pediatric individuals. On MRI, CLOCC show typical high T2 signal, low T1 signal, restricted diffusion, and lack of contrast enhancement. The majority of the lesions were reversible within the follow-up period (median follow-up 3 weeks). Interestingly, even though CLOCC were mostly associated with symptoms of the underlying disease, in exceptional cases, CLOCC were associated with callosal neurological symptoms. Of note, employed nomenclature for CLOCC was highly inconsistent.

Conclusions
Our study provides high-level evidence for clinical and imaging features of CLOCC as well as associated disease entities.

Clinical relevance statement
Our study provides high-level evidence on MRI features of CLOCC as well as a comprehensive list of disease entities potentially associated with CLOCC. Together, this will facilitate rigorous diagnostic workup of suspected CLOCC cases.

Key Points
• Cytotoxic lesions of the corpus callosum (CLOCC) are a frequent MRI feature associated with various systemic diseases.
• Cytotoxic lesions of the corpus callosum show a highly homogenous MRI presentation and temporal dynamics.
• This comprehensive overview will benefit (neuro)radiologists during diagnostic workup.
Ultra-processed foods and incident cardiovascular disease and hypertension in middle-aged women
Authors: Pant Anushriya , Gribbin Sarah , Machado Priscila , Hodge Allison , Wasfy Jason H. , Moran Lisa , Marschner Simone , Chow Clara K. , Zaman Sarah 
Published: December 2023

Abstract
Purpose
Ultra-processed food (UPF) intake has increased in recent decades, yet limited knowledge of long-term effects on cardiovascular health persists and sex-specific data is scant. We determined the association of UPF intake with incident cardiovascular disease (CVD) and/or hypertension in a population-based cohort of women.

Methods
In the Australian Longitudinal Study on Women’s Health, women aged 50–55 years were prospectively followed (2001–2016). UPFs were identified using NOVA classification and contribution of these foods to total dietary intake by weight was estimated. Primary endpoint was incident CVD (self-reported heart disease/stroke). Secondary endpoints were self-reported hypertension, all-cause mortality, type 2 diabetes mellitus, and/or obesity. Logistic regression models assessed associations between UPF intake and incident CVD, adjusting for socio-demographic, medical comorbidities, and dietary variables.

Results
We included 10,006 women (mean age 52.5 ± 1.5; mean UPF intake 26.6 ± 10.2% of total dietary intake), with 1038 (10.8%) incident CVD, 471 (4.7%) deaths, and 4204 (43.8%) hypertension cases over 15 years of follow-up. In multivariable-adjusted models, the highest [mean 42.0% total dietary intake] versus the lowest [mean 14.2% total dietary intake] quintile of UPF intake was associated with higher incident hypertension [odds ratio (OR) 1.39, 95% confidence interval (CI) 1.10–1.74; p = 0.005] with a linear trend (ptrend = 0.02), but not incident CVD [OR 1.22, 95% CI 0.92–1.61; p = 0.16] or all-cause mortality (OR 0.80, 95% CI 0.54–1.20; p = 0.28). Similar results were found after multiple imputations for missing values.

Conclusion
In women, higher UPF intake was associated with increased hypertension, but not incident CVD. These findings may support minimising UPFs within a healthy diet for women.
Quick and safe: why a k-wire-extension-block-fixation of a bony mallet finger is the favoured treatment
Authors: Stumpfe Maximilian C. , Suffa Nadine , Merkel Pauline , Ludolph Ingo , Arkudas Andreas , Horch Raymund E. 
Published: December 2023

Abstract
Introduction
Mallet fingers are the most common tendon injuries of the hand. Bony avulsion distal finger extensor tendon ruptures causing a mallet finger require special attention and management. In this monocentral study, we analyzed the clinical and individual outcomes succeeding minimal invasive k-wire extension block treatment of bony mallet fingers.

Materials and methods
In a retrospective study, we sent a self-designed template and a QUICK-DASH score questionnaire to all patients, who were treated because of a bony mallet finger between 2009 and 2022 and fulfilled the inclusion criteria. A total of 244 requests were sent out. 72 (29.5%) patients participated in the study. Forty-five men and twenty-seven women were included.

Results
98.7% (n = 75) of the cases were successfully treated. Patients were highly satisfied with the treatment (median 8.0; SD ± 2.9; range 1.0–10.0). Based on the QUICK-DASH score, all patients showed no difficulties in daily life. The extent of avulsion did not influence the outcome.

Conclusion
We conclude that the minimally invasive treatment of a bony mallet finger should be offered to every patient, because it is safe, fast, and reliable. Thus, we propose to perform extension-block pinning independently of the articular area.
Intraoperative liver deformation and organ motion caused by ventilation, laparotomy, and pneumoperitoneum in a porcine model for image-guided liver surgery
Authors: Wise Philipp A. , Preukschas Anas A. , Özmen Emre , Bellemann Nadine , Norajitra Tobias , Sommer Christof M. , Stock Christian , Mehrabi Arianeb , Müller-Stich Beat P. , Kenngott Hannes G. , Nickel Felix 
Published: December 2023

Abstract
Background
Image-guidance promises to make complex situations in liver interventions safer. Clinical success is limited by intraoperative organ motion due to ventilation and surgical manipulation. The aim was to assess influence of different ventilatory and operative states on liver motion in an experimental model.

Methods
Liver motion due to ventilation (expiration, middle, and full inspiration) and operative state (native, laparotomy, and pneumoperitoneum) was assessed in a live porcine model (n = 10). Computed tomography (CT)-scans were taken for each pig for each possible combination of factors. Liver motion was measured by the vectors between predefined landmarks along the hepatic vein tree between CT scans after image segmentation.

Results
Liver position changed significantly with ventilation. Peripheral regions of the liver showed significantly higher motion (maximal Euclidean motion 17.9 ± 2.7 mm) than central regions (maximal Euclidean motion 12.6 ± 2.1 mm, p < 0.001) across all operative states. The total average motion measured 11.6 ± 0.7 mm (p < 0.001). Between the operative states, the position of the liver changed the most from native state to pneumoperitoneum (14.6 ± 0.9 mm, p < 0.001). From native state to laparotomy comparatively, the displacement averaged 9.8 ± 1.2 mm (p < 0.001). With pneumoperitoneum, the breath-dependent liver motion was significantly reduced when compared to other modalities. Liver motion due to ventilation was 7.7 ± 0.6 mm during pneumoperitoneum, 13.9 ± 1.1 mm with laparotomy, and 13.5 ± 1.4 mm in the native state (p < 0.001 in all cases).

Conclusions
Ventilation and application of pneumoperitoneum caused significant changes in liver position. Liver motion was reduced but clearly measurable during pneumoperitoneum. Intraoperative guidance/navigation systems should therefore account for ventilation and intraoperative changes of liver position and peripheral deformation.
An international Delphi consensus for surgical quality assessment of lymphadenectomy and anastomosis in minimally invasive total gastrectomy for gastric cancer
Authors: Cizmic Amila , Romic Ivan , Balla Andrea , Barabino Nicolò , Anania Gabriele , Baiocchi Gian Luca , Bakula Branko , Balagué Carmen , Berlth Felix , Bintintan Vasile , Bracale Umberto , Egberts Jan-Hendrik , Fuchs Hans F. , Gisbertz Suzanne S. , Gockel Ines , Grimminger Peter , van Hillegersberg Richard , Inaki Noriyuki , Immanuel Arul , Korr Daniel , Lingohr Philipp , Mascagni Pietro , Melling Nathaniel , Milone Marco , Mintz Yoav , Morales-Conde Salvador , Moulla Yusef , Müller-Stich Beat P. , Nakajima Kiyokazu , Nilsson Magnus , Reeh Matthias , Sileri Pierpaolo , Targarona Eduardo M. , Ushimaru Yuki , Kim Young-Woo , Markar Sheraz , Nickel Felix , Mitra Anuja T. 
Published: December 2023

Abstract
Background
Minimally invasive total gastrectomy (MITG) is a mainstay for curative treatment of patients with gastric cancer. To define and standardize optimal surgical techniques and further improve clinical outcomes through the enhanced MITG surgical quality, there must be consensus on the key technical steps of lymphadenectomy and anastomosis creation, which is currently lacking. This study aimed to determine an expert consensus from an international panel regarding the technical aspects of the performance of MITG for oncological indications using the Delphi method.

Methods
A 100-point scoping survey was created based on the deconstruction of MITG into its key technical steps through local and international expert opinion and literature evidence. An international expert panel comprising upper gastrointestinal and general surgeons participated in multiple rounds of a Delphi consensus. The panelists voted on the issues concerning importance, difficulty, or agreement using an online questionnaire. A priori consensus standard was set at > 80% for agreement to a statement. Internal consistency and reliability were evaluated using Cronbach's α.

Results
Thirty expert upper gastrointestinal and general surgeons participated in three online Delphi rounds, generating a final consensus of 41 statements regarding MITG for gastric cancer. The consensus was gained from 22, 12, and 7 questions from Delphi rounds 1, 2, and 3, which were rephrased into the 41 statetments respectively. For lymphadenectomy and aspects of anastomosis creation, Cronbach’s α for round 1 was 0.896 and 0.886, and for round 2 was 0.848 and 0.779, regarding difficulty or importance.

Conclusions
The Delphi consensus defined 41 steps as crucial for performing a high-quality MITG for oncological indications based on the standards of an international panel. The results of this consensus provide a platform for creating and validating surgical quality assessment tools designed to improve clinical outcomes and standardize surgical quality in MITG.
Impact of dehydration on laparoscopic performance: a prospective, open-label, randomized cross-over trial
Authors: Bereuter Jean-Paul , Geissler Mark Enrik , Geissler Rona , Schmidt Sofia , Buck Nathalie , Weiß Juliane , Krause-Jüttler Grit , Weitz Jürgen , Distler Marius , von Bechtolsheim Felix , Oehme Florian 
Published: December 2023

Abstract
Introduction
During laparoscopic surgery, surgeons may experience prolonged periods without fluid intake, which might impact surgical performance, yet there are no objective data investigating this issue. Therefore, the aim of this study was to elucidate the effect of prolonged dehydration on laparoscopic surgical performance and tissue handling.

Methods
A total of 51 laparoscopic novices participated in a single-center, open-label, prospective randomized cross-over trial. All participants were trained to proficiency using a standardized laparoscopic training curriculum. Afterward, all participants performed four different laparoscopic tasks twice, once after 6 h without liquid intake (dehydrated group) and once without any restrictions (control group). Primary endpoints were tissue handling defined by force exertion, task time, and error rate. The real hydration status was assessed by biological parameters, like heart rate, blood pressure, and blood gas analysis.

Results
51 laparoscopic novices finished the curriculum and completed the tasks under both hydrated and dehydrated conditions. There were no significant differences in mean non-zero and peak force between the groups. However, dehydrated participants showed significantly slower task times in the Peg transfer task (hydrated: 139.2 s vs. dehydrated: 147.9 s, p = 0.034) and more errors regarding the precision in the laparoscopic suture and knot task (hydrated: 15.7% accuracy rate vs. dehydrated: 41.2% accuracy rate, p < 0.001).

Conclusion
Prolonged periods of dehydration do not appear to have a substantial effect on the fundamental tissue handling skills in terms of force exertion among surgical novices. Nevertheless, the observed impact on speed and precision warrants attention.
Wound healing after therapy of oral potentially malignant disorders with a 445-nm semiconductor laser: a randomized clinical trial
Authors: Meisgeier Axel , Heymann Paul , Ziebart Thomas , Braun Andreas , Neff Andreas 
Published: December 2023

Abstract
Objectives
Oral potentially malignant disorders (OPMDs) are the most clinically relevant precursor lesions of the oral squamous cell carcinoma (OSCC). OSCC is one of the 15 most common cancers worldwide. OSCC is with its high rate of mortality an important cause of death worldwide. The diagnosis and therapy of clinically relevant precursor lesions of the OSCC is one of the main parts of prevention of this malignant disease. Targeted therapy is one of the main challenges concerning an oncologically safe tissue removal without overwhelming functional and aesthetic impairment.

Materials and methods
In this randomized controlled trial, a newly introduced intraoral 445-nm semiconductor laser (2W; cw-mode; SIROLaser Blue, Dentsply Sirona, Bensheim, Germany) was used in the therapy of OPMDs. Duration and course of wound healing, pain, and scar tissue formation were compared to classical cold blade removal with primary suture by measuring remaining wound area, tissue colorimetry, and visual analogue scale. The study includes 40 patients randomized using a random spreadsheet sequence in two groups (n1 = 20; n2 = 20).

Results
This comparative analysis revealed a significantly reduced remaining wound area after 1, 2, and 4 weeks in the laser group compared to the cold blade group (p < 0.05). In the laser group, a significantly reduced postoperative pain after 1 week was measured (p < 0.05).

Conclusion
Laser coagulation of OPMDs with the investigated 445-nm semiconductor laser is a safe, gentle, and predictable surgical procedure with beneficial wound healing and reduced postoperative discomfort.

Clinical relevance
Compared to the more invasive and bloody cold blade removal with scalpel, the 445-nm semiconductor laser could be a new functional less traumatic tool in the therapy of OPMDs. The method should be further investigated with regard to the identification of further possible indications.

Trail registration
German Clinical Trials Register No: DRKS00032626.
First order asymptotics of the sample average approximation method to solve risk averse stochastic programs
Authors: Krätschmer Volker 
Published: December 2023

AbstractWe investigate statistical properties of the optimal value of the Sample Average Approximation of stochastic programs, continuing the study (Krätschmer in Nonasymptotic upper estimates for errors of the sample average approximation method to solve risk averse stochastic programs, 2023. Forthcoming in SIAM J. Optim.). Central Limit Theorem type results are derived for the optimal value. As a crucial point the investigations are based on a new type of conditions from the theory of empirical processes which do not rely on pathwise analytical properties of the goal functions. In particular, continuity or convexity in the parameter is not imposed in advance as usual in the literature on the Sample Average Approximation method. It is also shown that the new condition is satisfied if the paths of the goal functions are Hölder continuous so that the main results carry over in this case. Moreover, the main results are applied to goal functions whose paths are piecewise Hölder continuous as e.g. in two stage mixed-integer programs. The main results are shown for classical risk neutral stochastic programs, but we also demonstrate how to apply them to the Sample Average Approximation of risk averse stochastic programs. In this respect we consider stochastic programs expressed in terms of absolute semideviations and divergence risk measures.
What does the future hold for a thermophilic and widely introduced gecko, Tarentola mauritanica (Squamata: Phyllodactylidae)?
Authors: Rato Catarina , Silva-Rocha Iolanda , Sillero Neftalí 
Published: December 2023

AbstractThe continuous growth and movement of the human population is increasing the frequency of translocating species from their native ranges to novel environments. However, biological invasions offer a rare opportunity to investigate how species can colonise and adapt to new conditions. In that sense, Ecological Niche Models (ENMs) can be a powerful tool to predict where invasive species will spread over the next decades, although they depend heavily on climatic niche conservatism between native and exotic ranges. To reduce these uncertainties, ENMs can be refined by accounting for dispersal constraints. The common wall gecko, Tarentola mauritanica is a native and widespread Mediterranean lizard that has been introduced across different tropical and sub-tropical regions. In this study, we aim to predict the potential and future distribution of T. mauritanica geckos using correlative models, its potential colonization regions under a dispersal model, and the niche overlap between native and introduced populations. The correlative models predict that the most suitable geographic areas for this gecko correspond to Mediterranean-type ecosystems, such as California, central Chile, the Cape Region of South Africa, around the Caspian Sea, south-eastern Asia, and south-western and southern Australia. The species distribution models projected to 2061–2080, forecast that the range of T. mauritanica is likely to shift towards northern latitudes but, surprisingly, not to expand. According to the dispersal models, T. mauritanica will be able to colonise a similar geographic range compared to the one obtained with the correlative models for the future. Finally, the niche overlap results demonstrate that T. mauritanica’s realised niche has not been conserved over space, as the naturalised climatic niche of the introduced populations differs significantly from its native one. The latter results suggest that there has been no climatic niche conservatism during the several introductions of T. mauritanica and that this species seems to be able to cope with novel and more humid environments, typical from the tropics.
Lightweight precise automatic extraction of exception preconditions in java methods
Authors: Marcilio Diego , Furia Carlo A. 
Published: December 2023

AbstractWhen a method throws an exception— its exception precondition—is a crucial element of the method’s documentation that clients should know to properly use it. Unfortunately, exceptional behavior is often poorly documented, and sensitive to changes in a project’s implementation details that can be onerous to keep synchronized with the documentation. We present wit, an automated technique that extracts the exception preconditions of Java methods and constructors. wit uses static analysis to analyze the paths in a method’s implementation that lead to throwing an exception. wit’s analysis is precise, in that it only reports exception preconditions that are correct and correspond to feasible exceptional behavior. It is also lightweight: it only needs the source code of the class (or classes) to be analyzed— without building or running the whole project. To this end, its design uses heuristics that give up some completeness (wit cannot infer all exception preconditions) in exchange for precision and ease of applicability. We ran wit on the JDK and 46 Java projects, where it discovered 30 487 exception preconditions in 24 461 methods, taking less than two seconds per analyzed public method on average. A manual analysis of a significant sample of these exception preconditions confirmed that wit is 100% precise, and demonstrated that it can document the exceptional behavior of Java methods.