bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of environmental, social and governance (ESG) scores on stock market: evidence from G7 countries
Authors: Kevser Mustafa , Tunçel Mert Baran , Gürsoy Samet , Zeren Feyyaz 
Published: November 2023

Purpose
This study aims to examine the effect of environmental, social and corporate governance (ESG) scores on stock markets for the period from February 2018 to December 2022 for G7 countries. Even though ESG is an established area of investigation, prior research has paid inadequate attention to the nexus of ESG scores and stock markets in G7 (Germany, USA, UK, Italy, France, Japan and Canada) countries.

Design/methodology/approach
This study covers G7 countries and uses a data set, which includes ESG scores and stock market returns from reporting channels including financial websites, and international indexes, between February 2018 and December 2022. Cross-section dependency and homogeneity tests were used with Konya (2006) panel causality test to investigate the relations of ESG scores and stock markets, and the research also conducted a separate analysis for each sub-dimension. Homogeneity/heterogeneity tests were also carried out in the research.

Findings
The findings suggest that causality from ESG scores to stock market (DAX) was determined only for Germany. Accordingly, it is understood that German companies have started to implement corporate social responsibility and ESG practices in their management strategies and reporting. These findings offer important implications for those who are considering investing in G7 countries, whether or not to consider ESG scores.

Originality/value
In this context, the research contributes to the existing literature on the relationships between ESG scores and stock markets, which are seen as a vital tool to meet the expectations of stakeholders.
Pain scoring systems in hospitalized horses with ocular disease
Authors: Jodzio Dayna , DeNotta Sally , Plummer Caryn , Sanchez Chris 
Published: November 2023

AbstractBackgroundPain recognition in hospitalized horses is challenging, and the utility of pain scoring systems in horses with ocular disease has not been well‐described.Hypothesis/ObjectivesEvaluate the horse grimace scale (HGS) and behavior pain score (BPS) in hospitalized horses with ocular disease. We hypothesized that HGS and BPS would be associated with different clinical progressions.AnimalsPrivately owned horses hospitalized for ocular disease between September 2018 and September 2020.MethodsRetrospective observational study. The HGS and BPS were recorded daily throughout hospitalization. Clinical progressions were categorized as: (a) discharge from hospital after medical treatment, (b) ophthalmic surgery (eg, keratectomy, conjunctival flap, amniotic membrane transplantation, corneal transplant), or (c) enucleation. Temporal trends in HGS and BPS were assessed using linear regression. Correlations among slope, intercept, and progression were determined using the Kruskal‐Wallis test.ResultsOf 65 horses that met inclusion criteria, 29 (45%) were discharged after exclusively medical management, 28 (43%) underwent ophthalmic surgery, and 8 (12%) underwent enucleation. Two horses (3%) had 2 ophthalmic surgeries performed. The BPS scores at admission were higher in horses that were managed medically than in those that underwent enucleation (P = .01). Horses requiring enucleation had higher increases in HGS (P = .02) and BPS (P = .01) during hospitalization than horses that were medically managed and a higher increase in BPS (P = .04) than horses that required ophthalmic surgery.Conclusions and Clinical ImportancePain scoring may represent a useful tool for monitoring progression and response to treatment in hospitalized horses with ocular disease.
Quantifying dimensional change in stochastic portfolio theory
Authors: Bayraktar Erhan , Kim Donghan , Tilva Abhishek 
Published: November 2023

AbstractIn this paper, we develop the theory of functional generation of portfolios in an equity market with changing dimension. By introducing dimensional jumps in the market, as well as jumps in stock capitalization between the dimensional jumps, we construct different types of self‐financing stock portfolios (additive, multiplicative, and rank‐based) in a very general setting. Our study explains how a dimensional change caused by a listing or delisting event of a stock, and unexpected shocks in the market, affect portfolio return. We also provide empirical analyses of some classical portfolios, quantifying the impact of dimensional change in portfolio performance relative to the market.
Experimental Study on Performance of a Solar Thermal-Driven Vapor Absorption System Integrated With Hot Thermal Energy Storage for Milk Chilling
Authors: Sharma Dinesh Kumar , Sharma Dilip , Ali Ahmed Hamza H. 
Published: November 2023

Abstract
Solar thermal-driven vapor absorption system has proven to be a feasible and viable cooling source. However, most reported installations for milk chilling applications are equipped with an auxiliary heater that consumes significant electricity/gas, making it economically unviable. In this study, the experimental investigation of the performance of a solar-powered vapor absorption chiller has been reported for milk chilling applications as per standard ISO 5708–2 II. It has been identified that the performance of the vapor absorption chiller is quite uncertain and underperforming while operated with the heat directly fed through the evacuated tube compound parabolic concentrator solar field due to diurnal and seasonal variations of solar radiation intensity. Therefore, hot thermal energy storage integration has been studied and analyzed in this study. The performance of the vapor absorption chiller has improved significantly with the use of hot thermal energy storage in the solar circuit as the coefficient of performance (COP) of the vapor absorption chiller improved up to 0.4, which was earlier around 0.25. Further, hot thermal energy storage provides better thermal management to increase the productivity and performance of the vapor absorption chiller, and the cooling time for the first milking is 2 h and 45 min. The performance of the vapor absorption chiller enhanced further up to 0.52 when supplied heat entirely with thermal energy storage. The energy efficiency ratio has a maximum value of 6.1, with an average of 4.3, whereas the thermal COP has an average of 0.35 and a maximum value of 0.52 when run with thermal energy storage alone.
Performance Evaluation of Micro-Textured Inserts Coupled With Solid Lubricants During the Sustainable Dry Machining of Inconel 825
Authors: Nayak Jyoti Prakash , Chetan  
Published: November 2023

Abstract
In this research work, the turning of Inconel 825 has been carried out using uncoated and coated laser-textured hard tungsten carbide (WC) cutting inserts. The efficacy of uncoated textured inserts has been tried to improve by impregnating them with micro-sized MoS2 and nano-TiC powder paste. The results of coated and uncoated textured inserts have been compared with the plain uncoated tungsten carbide insert. The use of solid lubricant-impregnated textured tools and coated textured tools has significantly reduced the cutting forces and chip–tool interface friction as compared to plain and normal textured tools. Upon the SEM analysis, high adhesion over the rake face of the plain tool has been observed. The excessive adhesion over the rake surface has been observed over the normal textured tool due to the derivative cutting phenomena. The use of MoS2 and nano-TiC-impregnated textured tools has significantly reduced the material adhesion over the rake surface by eliminating the derivative cutting effect. The use of AlTiSiN-coated textured tools has also restricted the extent of work material adhesion over the rake surface of the cutting insert.
DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε
Authors: Chang Huasong , Wu Hao , Hou Peili , Aizaz Muhammad , Yang Rukun , Xiang Aibiao , Qi Wenjing , He Hongbin , Wang Hongmei 
Published: November 2023

ABSTRACT
Discs large membrane-associated guanylate kinase (MAGUK) scaffold protein 1 (DLG1) plays important roles in cell contact and migration, but its role in antiviral innate immunity is not clear. In this study, the role of DLG1 in the antiviral innate immune response and its impact on type-I interferon (IFN-I) signaling were investigated. DLG1 plays a critical role in promoting the IFN-I response by inhibiting the autophagic degradation of the innate immune adaptor IκB kinase epsilon (IKKε). As a result, DLG1 effectively suppresses negative-stranded RNA virus replication, including that of viruses such as vesicular stomatitis virus, Sendai virus, and bovine ephemeral fever virus. DLG1 was found to enhance the production of IFN-β and IFN-stimulated genes, leading to the attenuation of virus propagation. Mechanistically, DLG1 competitively binds to the E3 ubiquitin ligase March2, preventing the ubiquitination and subsequent degradation of IKKε. Notably, March2 specifically catalyzes K27-linked polyubiquitination of IKKε. The interaction between March2 and IKKε is mediated by the transmembrane domain of March2 and the C-terminal domain of IKKε. Furthermore, p62 acts as a cargo receptor, recognizing ubiquitinated IKKε for eventual autophagic degradation, whereas the process is blocked by DLG1. Additionally, the results demonstrated a significant decrease in DLG1 mRNA and protein levels upon negative-stranded RNA virus infection. Overall, these findings provide insights into the molecular mechanisms by which DLG1 promotes IFN-I production by regulating IKKε expression to inhibit viral replication.

IMPORTANCE
The type-I interferon (IFN-I) signaling pathway is the first line of antiviral innate immunity. It must be precisely regulated against virus-induced damage. The tightly regulated mechanisms of action of host genes in the antiviral innate immune signaling pathway are still worth studying. Here, we report a novel role of DLG1 in positively regulating the IκB kinase epsilon (IKKε)-mediated IFN-I signaling response against negative-stranded RNA virus replication, whereas the RNA virus inhibits the expression of DLG1 for immune escape. Importantly, the E3 ligase March2 interacts with and promotes K27-linked polyubiquitination of IKKε, and p62 is a cargo receptor that recognizes ubiquitinated IKKε for eventual autophagic degradation. Together, the current findings elucidate the role of DLG1 in the antiviral IFN-I signaling pathway and viral infection repression.
Draft genome sequence of
Yarrowia lipolytica
NRRL Y-64008, an oleaginous yeast capable of growing on lignocellulosic hydrolysates
Authors: Jagtap Sujit Sadashiv , Liu Jing-Jing , Walukiewicz Hanna E. , Riley Robert , Ahrendt Steven , Koriabine Maxim , Cobaugh Kelly , Salamov Asaf , Yoshinaga Yuko , Ng Vivian , Daum Chris , Grigoriev Igor V. , Slininger Patricia J. , Dien Bruce S. , Jin Yong-Su , Rao Christopher V. 
Published: November 2023

ABSTRACT

Yarrowia lipolytica
is an oleaginous yeast that produces high titers of fatty acid-derived biofuels and biochemicals. It can grow on hydrophobic carbon sources and lignocellulosic hydrolysates. The genome sequence of
Y. lipolytica
NRRL Y-64008 is reported to aid in its development as a biotechnological chassis for producing biofuels and bioproducts.
Metagenome-assembled genomes of the GU0601 sample (the Han River, South Korea)
Authors: Jang YeongJun , Kang Jae-Shin , Bae Eun Hee , Lee JunMo 
Published: November 2023

ABSTRACT
We generated metagenome sequences of the GU0601 sample collected from the Han River and constructed metagenome-assembled genomes (MAGs) to identify their bacterial composition. We identified six MAGs belonging to Alphaproteobacteria, Cyanobacteria, and Flavobacteria.
The heat shock protein Hsc70-3 mediates an anti-apoptotic response critical for
Plasmodium
evasion of
Anopheles gambiae
immunity
Authors: Alves e Silva Thiago Luiz , Canepa Gaspar E. , Sweeney Brendan , Hessab Alvarenga Patricia , Zhao Ming , Vega-Rodríguez Joel , Molina-Cruz Alvaro , Barillas-Mury Carolina 
Published: November 2023

ABSTRACT

The mosquito immune system limits
Plasmodium
infection and malaria transmission.
Plasmodium falciparum
evades the mosquito defense response by expressing the surface protein
P. falciparum
P47 (Pfs47) that inhibits midgut epithelial nitration by interacting with the mosquito midgut P47 receptor (P47Rec). However, the mechanism by which P47Rec suppresses caspase-mediated nitration is unknown. Here, we show that epithelial invasion by Pfs47 knockout parasites is followed by an extrusion of cells undergoing caspase-mediated apoptosis, which triggers the release of hemocyte-derived microvesicles (HdMv’s), known to promote complement activation and ookinete lysis. In contrast, invasion by
P. falciparum
parasites that express Pfs47 accelerates the extrusion of damaged cells and disrupts caspase activation and HdMv release. The
Anopheles gambiae
heat shock protein 70 cognate 3 (Hsc70-3), the ortholog of
Drosophila
binding immunoglobulin protein, was identified as a molecular partner of P47Rec. Silencing of Hsc70-3 promotes lysis of Pfs47 wild-type parasites through a caspase S2-dependent mechanism. The interaction of P47Rec activates a Hsc70-3-mediated anti-apoptotic response that prevents caspase activation. The interaction of P47Rec with Hsc70-3 is necessary for
P. falciparum
to evade the mosquito early immune responses that target the ookinete stage.

IMPORTANCE

Malaria transmission by
Anopheles gambiae
mosquitoes is very effective, in part because the parasite expresses a surface protein called Pfs47 that allows it to evade the mosquito immune system. Here we investigate how this protein changes the response of mosquito midgut epithelial cells to invasion by the parasite. Pfs47 is known to interact with P47Rec, a mosquito midgut receptor. We found that Pf47Rec inhibits caspase-mediated apoptosis by interacting with the Hsc70-3. This disrupts nitration of midgut epithelial cells invaded by the parasite and the release of hemocyte-derived microvesicles, which are critical for effective activation of the mosquito complement system that eliminates the parasite.
Identification of Astrovirus in the virome of the upper and lower respiratory tracts of calves with acute signs of bronchopneumonia
Authors: Gaudino Maria , Salem Elias , Ducatez Mariette F. , Meyer Gilles 
Published: November 2023

ABSTRACT
Bovine Astroviruses (BAstV) are small single-stranded, positive-sense RNA viruses that have been historically associated with the infection of the enteric tract in cattle, causing outbreaks of diarrhea, especially in young immunologically naive calves. Long neglected, BAstV have recently regained interest as they have been associated with several nonsuppurative encephalitis cases in cattle as well as in other species. Yet, the difficulty in isolating the virus in conventional cell cultures prevents a full understanding of BAstV tropism and pathogenesis in this species. Here, we describe the metagenomic identification of BAstV in the respiratory tract of calves affected by respiratory distress in French farms. BastV were prevalently detected in the lower respiratory tract of sick calves; however, molecular testing of further cohorts of respiratory samples highlighted their presence also in nasal swabs. Phylogenetic analyses revealed two divergent clades for neurotropic and enteric BAstV, suggesting that their tropism is likely to be strain-specific. BAstV detected in the respiratory tract of calves with respiratory disease were genetically related to enteric strains already described in cattle in Asia, displaying between 85% and 95% nucleotide identity. In addition, the sequences from France belonged to the clade of BAstV identified in yaks, roe deer, and camelids, underlining the interspecies transmission potential of the virus. More studies are warranted to understand if BAstV have a potential role in the onset of bovine respiratory disease.

IMPORTANCE
Astroviruses (AstV) are known suspects of enteric disease in humans and livestock. Recently, AstV have been linked to encephalitis in immunocompromised patients and other animals, such as cattle, minks, and swine. In our study, we also identified AstV in the respiratory samples of calves with signs of bronchopneumonia, suggesting that their tropism could be even broader. We obtained one bovine AstV (BAstV) complete genome sequence by next-generation sequencing and showed that respiratory and enteric AstV from different species formed a divergent genetic cluster with AstV isolated from encephalitis cases, indicating that tropism might be strain-specific. These data provide further insight into understanding the biology of these understudied pathogens and suggest BAstV as a potential new candidate for bovine respiratory disease.
Differences in injury and concussion rates in a cohort of Canadian female and male youth Rugby Union: a step towards targeted prevention strategies
Authors: Shill Isla J , West Stephen W , Sick Stacy , Schneider Kathryn J , Wiley J Preston , Hagel Brent E , Black Amanda M , Emery Carolyn A 
Published: November 2023

ObjectiveTo examine differences in match and training musculoskeletal injury and concussion rates and describe mechanisms of concussion while considering previous playing experience in female and male Canadian high school Rugby Union (‘rugby’) players.MethodsA 2-year prospective cohort study was completed in a high school league (n=361 females, 421 player-seasons; n=429 males, 481 player-seasons) in Calgary, Canada over the 2018 and 2019 rugby playing seasons. Baseline testing was completed at the start of each season and injury surveillance and individual player participation through session attendance was documented to quantify individual-level player exposure hours. Injury incidence rates (IRs) and incidence rate ratios (IRRs) were calculated using Poisson regression, offset by player exposure hours and clustered by team.ResultsOverall match IR for females was 62% higher than males (overall IRR=1.62, 95% CI: 1.20 to 2.18) and the overall training IR was twice as high for females (overall IRR=2.15, 95% CI: 1.40 to 3.32). The female match concussion IR was 70% higher than the males (concussion IRR=1.70, 95% CI: 1.08 to 2.69). Females had a 75% greater tackle-related IR compared with males (IRR=1.75, 95% CI: 1.20 to 2.56). Additionally, female tacklers had a twofold greater rate of injury compared with male tacklers (IRR=2.17, 95% CI: 1.14 to 4.14). Previous playing experience was not associated with tackle-related injury or concussion IRs.ConclusionThe rate of injury and concussion was significantly higher in females within this Canadian high school cohort. These results emphasise the need for development, implementation and evaluation of female-specific injury and concussion prevention strategies to reduce injury and concussion in female youth rugby.
Trends and risk of recurrent preterm birth in pregnancy cohorts in rural Bangladesh, 1990–2019
Authors: Aktar Shaki , Nu U Tin , Rahman Monjur , Pervin Jesmin , Rahman Syed Moshfiqur , El Arifeen Shams , Persson Lars Åke , Rahman Anisur 
Published: November 2023

IntroductionA history of preterm birth reportedly increases the risk of subsequent preterm birth. This association has primarily been studied in high-income countries and not in low-income settings in transition with rapidly descending preterm birth figures. We evaluated the population-based trends of preterm births and recurrent preterm births and the risk of preterm birth recurrence in the second pregnancy based on prospectively studied pregnancy cohorts over three decades in Matlab, Bangladesh.MethodsA population-based cohort included 72 160 live births from 1990 to 2019. We calculated preterm birth and recurrent preterm birth trends. We assessed the odds of preterm birth recurrence based on a subsample of 14 567 women with live-born singletons in their first and second pregnancies. We used logistic regression and presented the associations by OR with a 95% CI.ResultsThe proportion of preterm births decreased from 25% in 1990 to 13% in 2019. The recurrent preterm births had a similar, falling pattern from 7.4% to 3.1% across the same period, contributing 27% of the total number of preterm births in the population. The odds of second pregnancy preterm birth were doubled (OR 2.18; 95% CI 1.96 to 2.43) in women with preterm birth compared with the women with term birth in their first pregnancies, remaining similar over the study period. The lower the gestational age at the first birth, the higher the odds of preterm birth in the subsequent pregnancy (test for trend p<0.001).ConclusionIn this rural Bangladeshi setting, recurrent preterm births contributed a sizeable proportion of the total number of preterm births at the population level. The increased risk of recurrence remained similar across three decades when the total proportion of preterm births was reduced from 25% to 13%.
Improving early infant diagnosis for HIV-exposed infants using unmanned aerial vehicles for blood sample transportation in Conakry, Guinea: a comparative cost-effectiveness analysis
Authors: Inghels Maxime , Mee Paul , Diallo Oumou Hawa , Cissé Mohamed , Nelson David , Tanser Frank , Asghar Zahid , Koita Youssouf , Laborde-Balen Gabrièle , Breton Guillaume 
Published: November 2023

BackgroundEarly infant diagnosis (EID) for HIV-exposed infants is essential due to high mortality during the first months of their lives. In Conakry (Guinea), timely EID is difficult as traffic congestion prevents the rapid transport of blood samples to the central laboratory. We investigated the cost-effectiveness of transporting EID blood samples by unmanned aerial vehicles (UAV), also known as drones.Methods and findingsUsing Monte Carlo simulations, we conducted a cost-effectiveness comparative analysis between EID blood samples transportation by on-demand UAV transportation versus the baseline scenario (ie, van with irregular collection schedules) and compared with a hypothetic on-demand motorcycle transportation system. Incremental cost-effectiveness ratio (ICER) per life-year gained was computed. Simulation models included parameters such as consultation timing (eg, time of arrival), motorcycle and UAV characteristics, weather and traffic conditions. Over the 5-year period programme, the UAV and motorcycle strategies were able to save a cumulative additional 834.8 life-years (585.1–1084.5) and 794.7 life-years (550.3–1039.0), respectively, compared with the baseline scenario. The ICER per life-year gained found were US$535 for the UAV strategy versus baseline scenario, US$504 for the motorcycle strategy versus baseline scenario and US$1137 per additional life-year gained for the UAV versus motorcycle strategy. Respectively, those ICERs represented 44.8%, 42.2% and 95.2% of the national gross domestic product (GDP) per capita in Guinea—that is, US$1194.ConclusionCompared with the baseline strategy, both transportation of EID blood samples by UAVs or motorcycles had a cost per additional life-year gained below half of the national GDP per capita and could be seen as cost-effective in Conakry. A UAV strategy can save more lives than a motorcycle one although the cost needed per additional life-year gained might need to consider alongside budget impact and feasibility considerations.