bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far From Help: Exploring the Influence of Regional and Remote Residence on Coastal Visitation and Participation, Risk Perception and Safety Knowledge and Practices
Authors: Pratt Ella G. , Peden Amy E. , Lawes Jasmin C. 
Published: February 2025

ABSTRACTObjectiveTo explore how self‐reported coastal visitation, participation, risk perception, safety knowledge, experiences and safety practices differed between regional and remote, and major city residents to inform remoteness‐specific coastal drowning prevention efforts.MethodsThis study used data obtained from the annual National Coastal Safety Survey from 2018 to 2023. Data were postweighted proportionally according to age, gender and Australian Statistical Geography Standard classification using 2021 census population data. Descriptive statistics and chi‐square analyses were used to identify key differences in the behaviours, knowledge, and experiences of regional and remote respondents as compared to major city respondents.ResultsA total of 14 210 respondents were included in this dataset. Regional and remote respondents were more likely to visit an unpatrolled beach, particularly when swimming/wading (n = 929, 42.3%; χ2 = 502.14, p < 0.001). However, similar proportions of regional and remote and major city respondents reported following safety practices on patrolled beaches. Regional and remote respondents were more likely to consider sea and weather conditions for all coastal activities, but there was little difference between remoteness groups regarding rip current identification, perceptions and experiences.DiscussionThis study demonstrates that future coastal safety research should consider the impact of remoteness to corroborate the findings of this study: that a significant contributor to the regional and remote drowning burden is a lack of access to patrolled beaches.ConclusionsRegional and remote residents are more likely to frequent unpatrolled beaches but, if able to visit a patrolled beach, are just as likely as major city residents to adhere to safety practices.
Sculponeatin A induces mitochondrial dysfunction in non‐small cell lung cancer through WWP2‐mediated degradation of mitochondrial STAT3
Authors: Wan Fang , Qian Chen , Liu Xuewen , Zhong Yifan , Peng Wenkang , Zhang Liang , Zhan Xiangrong , Huang Yongtong , Zhang Chengyu , Wang Jiu , Si Yuan , Liu Ying 
Published: February 2025

AbstractBackground and PurposeThe phosphorylation of signal transducer and activator of transcription 3 (STAT3) monomer at S727 promotes its mitochondrial localisation and regulates mitochondrial function, thus exerting a protective effect on tumour cells. However, no inhibitor drugs targeting mitochondrial STAT3 (mitoSTAT3) or S727‐STAT3 phosphorylation have been identified. Here, we report a novel diterpenoid extracted from Isodon sculponeatus, sculponeatin A (sptA), induces mitochondrial dysfunction in non‐small cell lung cancer (NSCLC) by targeting mitoSTAT3 degradation.Experimental ApproachxCELLigence real‐time cell analysis assay and high‐content analysis were performed to measure cytotoxicity. Mitochondrial function was assessed by transmission electron microscopy, mitochondrial permeability transition pore opening and Seahorse cellular flux assays. The effects of sptA on the upstream signalling pathway of mitochondrial dysfunction were measured by Western blot, gene alterations and other approaches. Immunofluorescence and live cell imaging were performed to visualise the expression and position of mitoSTAT3. Nude mice and zebrafish were modelled with subcutaneous xenografts. Pharmacokinetics of sptA were examined in rats. Drug toxicity was evaluated in zebrafish.Key ResultssptA inhibited mitochondrial respiration in NSCLC cells. sptA induced mitochondrial dysfunction by promoting the degradation of mitoSTAT3. sptA promoted WW domain containing E3 ubiquitin protein ligase 2 (WWP2)‐mediated ubiquitination and degradation of mitoSTAT3 through direct binding. sptA inhibited tumour growth in vivo. Evaluation of drug toxicity in zebrafish showed that overdose of sptA may cause heart damage.Conclusions and ImplicationsThese findings suggest that pharmacological targeting the degradation of mitoSTAT3 by sptA may provide therapeutic benefits against NSCLC.
Children of Divorced Parents—The Limitations of One‐Size‐Fits‐All Interventions
Authors: Hansen Pernelle Rose 
Published: February 2025

ABSTRACTThe political agenda of the Danish School Reform in 2014 provides a heightened awareness of pupils' mental health–including children of divorced parents. The primary focus is to support children's emotion management, and in that regard, conversation groups are offered to children experiencing divorce. The conversation groups are primarily built on manual‐based and therapeutic concepts, rooted in well‐intentioned care work. In service of good intentions, the metaphor of the lump is employed as a significant tool to describe children's difficult emotions. This can be linked to an overall therapeutic tendency that has developed within institutional arenas for children and adolescents. However, these understandings position children between normalization and problematization. In order to provide help and support for children living their everyday lives with divorce, professionals can (unintentionally) be the bearers of problematized understandings. However, the well‐meaning intentions of care can paradoxically act as a ‘power of goodness’. This article stems from a qualitative research project involving 23 children and adolescents who participated in conversation groups at four Danish schools.
Incorporating cyclone risk in the design of marine protected and conserved areas as an ecosystem‐based adaptation approach
Authors: Giffin Alyssa L. , Tulloch Vivitskaia J. D. , Andradi‐Brown Dominic A. , Connolly Rod M. , Malani‐Tagicakibau Unaisi , Areki Francis , Brown Christopher J. 
Published: February 2025

AbstractMarine protected and conserved areas (MPCAs) are promoted as an ecosystem‐based adaptation (EbA) approach to increase community and ecosystem resilience to climate change. However, traditional approaches to MPCA design typically do not consider climate risk or habitat condition under a climate threat. We used the Great Sea Reef (GSR) in Fiji as a case study to develop a land–sea prioritization framework that links modeled sediment runoff from rainfall during extreme cyclone events to the probability of coral reefs being in good condition. We incorporated this information in an MPCA prioritization scenario intending to achieve 90% certainty of good‐condition coral cover under cyclone risk while minimizing cost to fishers and meeting ecosystem conservation targets. We explored the trade‐offs between sites selected for protection, the relative opportunity cost to fishers, and the representation of conservation feature targets between the MPCA scenario that included cyclone risk and a baseline scenario that did not. The cyclone risk scenario's best solution required larger areas of protection (5% more GSR area) than the baseline scenario and additional protection in areas with moderate to high probability of good‐condition coral cover. Some areas prioritized for protection in the cyclone risk scenario had relatively high turbidity. Large sections around Vanua Levu were consistently selected for protection across both prioritization scenarios due to high concentrations of all ecosystem conservation features, particularly sea turtle feeding grounds. Overall, the cyclone risk MPCA design had a higher fisher opportunity cost but protected a larger amount of ecosystem conservation features and buffered against habitat condition uncertainty. We explored the potential outcomes of expanding on threat‐avoidance and cost‐effective conservation prioritization by including habitat responses to threats in the prioritization process. Our findings can inform MPCA design during EbA planning in regions at risk from climate change.
The Interplay of School Cultural Dynamics and Change: Exploring the Resistance to School Change
Authors: Bakır Dilşad , Altunay Esen 
Published: February 2025

ABSTRACTThis study aimed to explore the cultural barriers to change in public primary and secondary schools in Türkiye. The study is based on a qualitative research approach. The participants consist of 42 school leaders working in various primary and secondary schools in Türkiye. Data originated from semi‐structured interviews and observations, and content analysis was conducted during the data analysis. Regarding the characteristics of school cultures, the participants emphasised an organisational culture that is open to innovation and solidarity among individuals. Concerning the cultural barriers to change in schools, the resistance to innovation was highlighted as linked to individual behaviour. Finally, the way in which school members resist change is important. The results highlight a lack of cooperation as one of the main barriers to change. Resistance to collaboration and lack of development of professional learning networks currently inhibit school change in Türkiye. The results show that cultural factors affect the success of change initiatives in schools that are open systems, and understanding and overcoming obstacles. Starting the change process in this way can transform schools into learning and developing organisations.
Plant Species Better Adapted to Climate Change Need Agricultural Extensification to Persist
Authors: Poinas Isis , Meynard Christine N. , Fried Guillaume 
Published: February 2025

ABSTRACTAgricultural intensification and climate change have led to well‐known vegetation shifts in agricultural landscapes. However, concomitant plant functional changes in agroecosystems, especially at large scales, have been seldom characterised. Here, we used a standardised yearly monitoring of > 400 agricultural field margins in France to assess the temporal response of vegetation diversity and functional traits to variations in climate and intensity of agricultural practices (herbicides, fertilisation and mowing) between 2013 and 2021. We observed clear temporal trends of increasing warming and aridity, but trends towards agricultural extensification were weak or nonsignificant. Our results showed functional changes in plant communities over time, driven mostly by climate change and suggested selective forces opposing climate change to agricultural intensification. This translated as a temporal decline of competitive and ruderal species in favour of stress‐tolerant species, putting plant communities in agroecosystems in a difficult position to escape both climate and agricultural pressures at the same time.
Beyond the hanger: Investigation of consumers' sustainable disposal behavior of clothing items
Authors: Jahura Fatema Tuj , Sadachar Amrut 
Published: February 2025

AbstractThis study investigated the personal and situational factors that influence consumers' sustainable clothing disposal behavior using the theory of interpersonal behavior. Data were collected via an online survey of 293 U.S. participants and analyzed using regression techniques. The results supported five of the six hypotheses, indicating that both attitudes toward environmentally friendly clothing and positive affect toward sustainable disposal behavior are significant predictors of disposal intentions. However, perceived social pressure was not found to have a significant impact. Furthermore, perceived convenience, sustainable disposal intentions, and established recycling habits were identified as key predictors of actual sustainable clothing disposal behavior.
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma
Authors: Gauthier Marc , Kale Sagar L. , Ray Anuradha 
Published: February 2025

ABSTRACTAsthma is orchestrated by an aberrant immune response involving a complex interplay between multiple inflammatory cell types. An increase in Th2 cells in the asthmatic airway is a hallmark of asthma, and biologics blocking their effector functions have been life‐changing for many severe asthma patients who poorly respond to immunosuppression by corticosteroids. However, studies in the past decade have highlighted not only other cell types that also produce Th2 cytokines boosting the Type 2/T2 phenotype but also a heightened IFN‐γ response, primarily from T cells, referred to as a Type 1/T1 immune response. Data derived from studies of immune cells in the airways and mouse models of severe asthma suggest a role of IFN‐γ in corticosteroid resistance, airway hyperreactivity, and also airway remodeling via effects on other cell types including mast cells, eosinophils, airway epithelial cells, and airway smooth muscle cells. The simultaneous presence of T1 and T2 immune responses is detectable in the sickest of asthma patients in whom corticosteroids suppress the T2 but not the T1 response. This article has reviewed our current understanding of the complex T1–T2 interplay in severe asthma highlighting mediators that impact both arms which may be targeted alone or in combination for disease alleviation.
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma
Authors: Joulia Régis , Lloyd Clare M. 
Published: February 2025

ABSTRACTChronic lung diseases including asthma are characterized by an abnormal immune response and active tissue remodeling. These changes in the architecture of the tissue are a fundamental part of the pathology across the life course of patients suffering from asthma. Current treatments aim at dampening the immune system hyperactivation, but effective drugs targeting stromal or acellular structures are still lacking. This is mainly due to the lack of a detailed understanding of the composition of the large airways and the cellular interactions taking place in this niche. We and others have revealed multiple aspects of the spatial architecture of the airway wall in response to airborne insults. In this review, we discuss four elements that we believe should be the focus of future asthma research across the life course, to increase understanding and improve therapies: (i) specialized lung niches, (ii) the 3D architecture of the epithelium, (iii) the extracellular matrix, and (iv) the vasculature. These components comprise the main stromal structures at the airway wall, each playing a key role in the development of asthma and directing the immune response. We summarize promising future directions that will enhance lung research, ultimately benefiting patients with asthma.
Unveiling Patterns of Interaction With Automated Feedback in Writing Mentor and Their Relationships With Use Goals and Writing Outcomes
Authors: Jiang Yang , Klebanov Beata Beigman , Hao Jiangang , Deane Paul , Livne Oren E. 
Published: February 2025

ABSTRACTBackgroundWriting is integral to educational success at all levels and to success in the workplace. However, low literacy is a global challenge, and many students lack sufficient skills to be good writers. With the rapid advance of technology, computer‐based tools that provide automated feedback are being increasingly developed. However, mixed results have been obtained so far on the effects of writing feedback, and little is known about how various types of feedback are used by users who access feedback with different goals.ObjectivesLeveraging both process and response data, the present study investigated students' interactions with feedback in Writing Mentor (WM), an app designed to support academic writing through automated feedback and NLP techniques.MethodsWe identified 1857 documents submitted by middle‐ and high‐school students among users‐in‐the‐wild and explored the activities that students engaged in while using WM and the quality of their submitted written products. Students' interaction processes and behaviours were compared across groups of students with different goals for using WM. In addition, sequential pattern mining was applied to identify interesting sequential patterns of student interactions with the writing feedback features that are differentially frequent across goal groups.Results and ConclusionsResults indicated that students with different goals for using WM displayed different patterns of interaction. Furthermore, the effects of the various types of feedback on writing quality vary by students' purposes for using the tool. Findings from this study shed light on the design of computer‐based writing tools and automated writing feedback for learners of various needs.
Effect of Multidimensional Integrated Lung Protection Measures in Elderly Patients With Fragile Lungs or Combined Lung Dysfunction by Regulating AMPK/SIRT1 Pathway
Authors: Cui Yinghui , Tao Haiyong , Hu Shejun , Zhang Yan , Li Hao , Wang Jinhuo , Wu Mandi , Guo Jianrong 
Published: February 2025

ABSTRACTFragile lungs or lung dysfunction can significantly impact a patient's quality of life. Currently, no specific treatment exists to prevent lung dysfunction in elderly patients. The detailed mechanism of fragile lungs or lung dysfunction in elderly patients remains elusive, and this study aimed to clarify it. General data and blood specimens were obtained from patients with fragile lungs or lung dysfunction. The mice were exposed to cigarette smoke using a smoking apparatus to induce fragile lungs or lung dysfunction mice model. Blood samples and lung tissues were collected from all groups for further testing. haematoxylin–eosin (HE) staining, immunofluorescence, Western blot, flow cytometry and quantitative reverse transcriptase PCR (qRT‐PCR) were used to elucidate the molecular mechanisms of multidimensional integrated lung protection measures (MILPM) in fragile lungs or lung dysfunction mice by targeting the AMP‐activated protein kinase (AMPK)/Sirtuin 1 (SIRT1) pathway. The results indicated that upregulation of the AMPK/SIRT1 signalling pathway accelerates the fragile lungs or lung dysfunction process, whereas downregulation of the AMPK/SIRT1 signalling pathway can prevent it. Similarly, the change of forced vital capacity (FVC), total lung capacity (TLC) levels is associated with the fragile lungs or lung dysfunction process, whereas reducing their levels can serve as a preventative method against fragile lungs or lung dysfunction development. Upregulation of the AMPK/SIRT1 pathway can accelerate the process of fragile lungs or lung dysfunction.
Shock Anticipation: Voluntary Turnover by Foreign Directors in Response to Sanctions on Peer Firms
Authors: Liu Xiaomeng , Zhou Abby Jingzi , Zhou Steven Shijin , Bai Tao , Tan Xue 
Published: February 2025

AbstractThis paper proposes a new turnover mechanism, namely shock anticipation, which explains how the anticipation of potential shocks triggers voluntary turnover by individuals in organizations. Drawing on the context of US sanctions on China initiated in 2018, we analyse a sample of foreign directors (FDs) from Chinese‐listed firms between 2014 and 2021. We suggest sanctions on peer firms lead FDs to anticipate potential sanctions on their own organizations and become concerned about the associated negative effects on their careers, which in turn motivates their turnover. We further argue that FDs at state‐owned enterprises (SOEs) anticipate a higher risk and, consequently, are more likely to leave after observing sanctions imposed on their peer firms. In contrast, FDs with shorter career horizons are less inclined to leave as they perceive diminished damage to their future career. Our empirical results provide robust support for these hypotheses. This study enriches the literature on turnover and sanctions while also offering practical implications.
Neuroinvasion via Peripheral Nerves in Epidemic Viral Encephalitis Caused by Enterovirus, Orthoflavivirus and SARS‐Coronavirus
Authors: Hooi Yuan Teng , Fu Tzeh Long , Tan Soon Hao , Ong Kien Chai , Tan Chee Yang , Wong Kum Thong 
Published: February 2025

ABSTRACTPathogens invade the central nervous system (CNS) and cause infections either through the haematogenous route or via peripheral nerves. Neuroinvasion via peripheral nerves, involving spinal or cranial somatic nerves, is well‐established for certain viral encephalitides such as rabies, herpes simplex encephalitis, and poliomyelitis. Advances in understanding emerging and re‐emerging viruses that cause epidemic CNS infections have highlighted the growing importance of peripheral nerve pathways in viral neuroinvasion. This review focuses on epidemic viral encephalitides caused by three groups of RNA viruses, viz., enteroviruses (enterovirus A71 and enterovirus D68), orthoflaviviruses (West Nile virus and Japanese encephalitis virus), and severe acute respiratory syndrome coronaviruses (mainly severe acute respiratory coronavirus‐2). We examine evidence supporting the hypothesis that peripheral nerve viral transmission may play an increasingly significant if not more critical role than the haematogenous route in neuroinvasion.
The Effects of Pursed Lip Breathing Exercises on Patients' Post‐Bronchoscopy Recovery Parameters: A Nurse‐Led Quasi‐Experimental Study
Authors: Alqadi Rasha Abdulhalim , Habiba Azza Ibrahim Abdelkader , El Sayed Akl Hanaa Hamad Mohamed , Khamis Engy AbdelRhman , Berdida Daniel Joseph E. 
Published: February 2025

ABSTRACTPursed‐lip breathing (PLB) exercises are used as a nursing intervention among post‐bronchoscopy patients. However, there is limited evidence of their effectiveness in improving post‐bronchoscopy recovery status. This study investigated the effect of the PLB exercise program on patients' post‐bronchoscopy recovery parameters. A nurse‐led quasi‐experimental research involving study and control groups involving 60 adult participants who were randomly divided into two equal groups. A three‐part questionnaire was used for data collection from October 2022 to April 2023. Shapiro–Wilk test, chi‐square test, Fisher's exact test, Cochran's test, post hoc test (Dunn's), student's t‐test, and Friedman test were employed for data analyses. There were significant improvements in temperature, pulse, respiration, blood pressure, oxygen saturation, chest pain, and peak expiratory flow in the study group, with statistically significant difference after 30 min. PLB exercises enhanced the clinical outcomes of the study group participants compared to the control group in improving respiratory and cardiac status post‐bronchoscopy. Nursing service units may conduct in‐service training programs for nursing staff about applying PLB techniques and endorse this as a part of routine care to improve patients' clinical outcomes post‐bronchoscopy.
Trade‐off between spring phenological sensitivities to temperature and precipitation across species and space in alpine grasslands over the Qinghai–Tibetan Plateau
Authors: Li Xiaoting , Guo Wei , He Hao , Wang Hao , Classen Aimée , Wu Donghai , Ma Yixin , Wang Yunqiang , He Jin‐Sheng , Xu Xiangtao 
Published: February 2025

Summary
Elucidating climatic drivers of spring phenology in alpine grasslands is critical. However, current statistical estimates of spring phenological sensitivities to temperature and precipitation (βT and βP) might be biased and their variability across sites and species are not fully explained.
We benchmarked species‐level βT and βP statistically inferred from historical records with observations from a field manipulative experiment. We then analyzed landscape scale βT and βP estimated from the best statistical approach in the benchmark analysis across 57 alpine grassland sites in the Qinghai–Tibetan Plateau.
Compared with manipulative experiment results, process‐agnostic regression‐based approaches underestimate βT by 2.36–3.87 d °C−1 (54–88%) while process‐based phenology model fitting predicts comparable βT and βP. Process‐based estimates of βT and βP are negatively correlated across species (R = −0.94, P < 0.01) and across sites (R = −0.45, P < 0.01). βT is positively correlated with mean annual temperature, and βP is negatively correlated with elevation at the regional scale.
Using process‐based model fitting can better estimate spring phenological sensitivities to climate. The trade‐off between βT and βP contributes to species‐level and site‐level variabilities in phenological sensitivities in alpine grasslands, which needs to be incorporated in predicting future phenological changes.