bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendidikan Karakter Generasi Muda Pada Era Global
Authors: Istiasari Tiray Anggraini , Hidayah Kafa , Indah Budhi , Safitri Lola 
Published: January 2024

Abstract. This article was written using descriptive research methods. The study was conducted to determine the extent of character education in young generation. Seeing the rapid development of the times, many children, especially young generation, are less moral and socially good in social life. At this time, character education is very much needed to form the next generation of superior and quality nations by cultivating a responsible spirit to face this global era. Character education can optimize the development of a person's dimensions cognitively, physically, socially-emotionally, creatively, and spiritually. Character education aims to form and strengthen spiritual, moral, and ethical foundations so that humans are formed who are devoted to God Almighty, comply with applicable legal norms and rules, and can apply the noble values of the nation's culture.Keywords: Character education, young generation, Global era

Abstrak. Artikel ini ditulis menggunakan metode penelitian deskriptif. Penelitian dilakukan untuk mengetahui sejauh mana pendidikan karakter pada geneasi muda. Melihat pesatnya perkembangan zaman, banyak anak utamanya generasi muda ini yang kurang bermoral dan sosial yang baik dalam kehidupan bermasyarakat. Pada saat ini pendndikan karakter sangat dibutuhkan untuk membentuk generasi penerus bangsa yang unggul dan berkualitas dengan menumbuhkan jiwa bertanggungjawab untuk menghadapi era global ini. Pendidikan karakter dapat mengoptimalkan perkembangan dimensi seseorang secara kognitif, fisik, social-emosional, kreatif, dan spiritual. Pendidikan karakter bertujuan untuk membentuk dan memantapkan landasan spiritual, moral, dan etika sehingga terbentuk manusia yang bertaqwa kepada Tuhan Yang Maha Esa, mematuhi norma dan aturan hukum yang berlaku, serta dapat menerapkan nilai luhur budaya bangsa.Kata Kunci: Pendidikan karakter, generasi muda, Era global
Peran Penting Keluarga Dalam Tumbuh Kembang Kepribadian Anak
Authors: Rahmelia Dinda , Kailola Renauldo Elphid , Jamalludin Rojak , Zahroq Varikha Fatimatul 
Published: January 2024

Abstract. Character education is very important; this is the main human capital for social life. Character education is also sustainable with morals. Gaining this knowledge is not only at school but also at home and in the social environment. Competition for quality human resources will occur in the coming year. Surely it will be a burden on us and our parents at this time. Creating quality human resources definitely requires good character, so it needs to be educated from an early age, to get used to good character in children.Keywords: -

Abstrak. Pendidikan karakter itu sangat penting, ini adalah modal utama manusia untuk berkehidupan sosial. Pendidikan Karakter juga berkesinambungan dengan moral.Mendapatkan ilmu ini bukan hanya di sekolah saja tetapi juga di rumah dan lingkungan sosial. Kompetisi SDM yang berkualitas akan terjadi pada tahun yang akan datang. Pasti itu akan menjadi beban kita dan orangtua saat ini. Menciptakan SDM berkualitas pasti membutuhkan karakter yang baik,maka perlu di didik sejak dini,untuk membiasakan karakter yang baik pada anak.Kata kunci: -
IMPACT ON LIQUIDITY, SOLVENCY AND PROFITABILITY IN THE STOCK PRICE
Authors: Kusumowati Dewi , Deda Ferdinandus Seran 
Published: January 2024

This study aims to examine and analyze the effect of liquidity ratios (current ratio, quick ratio), solvency (debt to equity ratio, debt to assets ratio), and profitability (return on assets, return on equity) on stock prices in the manufacturing sub-sector of automotive companies that listed on the Indonesia Stock Exchange. This research is quantitative descriptive. The population in this study is the automotive sub-sector companies listed on the Indonesia Stock Exchange for the 2016-2020 period. The sample in this study was determined by purposive sampling method in order to obtain a sample of 10 companies and a total of 50 observational data. The data source used was secondary data obtained from the Indonesia Stock Exchange. The type of data in this study is quantitative data. The analysis technique used is the classical assumption test, multiple linear regression analysis, and hypothesis testing. The results showed that the Current Ratio, Debt to Equity Ratio, and Debt to Asset Ratio had no significant effect on stock prices. Meanwhile, Quick Ratio, Return on Assets, and Return on Equity have a significant effect on stock prices.
Efektivitas pajak daerah dan retribusi daerah terhadap pendapatan asli daerah Kabupaten Bondowoso
Authors: Anugerah Adellia , Handayawati Kuni , Fatimah Annisa 
Published: January 2024

This study aimed to determine the effectiveness of the regional taxes and regional levies on The Regional Original Income (PAD) at the Regional Revenue Agency of Bondowoso Regency in 2017-2021 (before and during the Covid-19 pandemic) and their policies. This research was processed by a qualitative descriptive method with interviews and documentation as data collection methods. The research data sources came from the Government Agency Performance Report (LKIP) of Bapenda and the Bondowoso Regency Regional Budget Realization Report for 2017-2021. The effectiveness ratio used as an analytical tool was in the form of a formula which was a comparison between the taxes and the budget multiplied by one hundred percent which was adjusted to the criteria for measuring effectiveness. The results showed the effectiveness of the regional taxes and the levies before the Covid-19 pandemic (2017-2019) with very effective criteria, namely 100% on the regional taxes and 106% on the regional levies. Meanwhile, the effectiveness of regional taxes and levies during the Covid-19 pandemic (2020-2021) has an effective criterion of 95% on the regional taxes and 75% on the regional levies.
A clinical case of a combined method for correcting postkeratoplastic astigmatism of a high degree in a patient with cataract
Authors: Sinitsyn M. V. , Pozdeyeva N. A. 
Published: January 2024

Background. Performing penetrating keratoplasty in 100 % of cases leads to the occurrence of induced postkeratoplasty astigmatism, which can be more than 12,0 D. If cataracts occur in this category of patients, performing cataract phacoemulsification with implantation of a toric intraocular lens (tIOL) does not completely solve the problem. The use of the method of implantation of intrastromal corneal segments at stage I before cataract phacoemulsification makes it possible to reduce the degree of postkeratoplasty astigmatism and create optimal conditions for additional correction of residual postkeratoplasty astigmatism due to the implantation of tIOL during cataract phacoemulsification.The aim. To analyze the clinical and functional indicators of correction of regular high-grade postkeratoplasty astigmatism in a patient with cataracts using a combined method, including first implantation of intrastromal corneal segments and subsequent cataract phacoemulsification with implantation of toric intraocular lens using the example of a clinical case.Material and methods. A 55-year-old patient with cataracts, who had a history of undergoing penetrating keratoplasty, contacted us. According to the keratotopogram data, a regular postkeratoplasty astigmatism of 18.68 D was diagnosed. The patient underwent a combined method. At stage I, intrastromal corneal segments were implanted into the corneal graft, then after 6 months stage II was performed – cataract phacoemulsification with implantation of tIOL.Results. Six months after intrastromal corneal segments implantation, the patient’s keratometric data stabilized, and corneal astigmatism decreased to 8.98 D. Then the patient underwent cataract phacoemulsification with tIOL implantation. After 1 month, the spherical component of refraction was 0.5 D, the cylindrical component of refraction was –0.5 D, visual acuity increased to 1.0.Conclusions. A combined method for correcting regular high-grade postkeratoplasty astigmatism in a patient with cataracts showed high refractive results, stability and safety in the long-term postoperative period.
Role of <i>ITGB3</i>, <i>GP1B1</i>, and <i>ITGA2</i> gene polymorphisms in platelet dysfunction in patients with COVID-19-associated lung damage
Authors: Osikov M. V. , Antonov V. N. , Zotov S. O. 
Published: January 2024

The aim of the work. To investigate platelet aggregation, polymorphism in the genes that ensure its implementation, and the association between these indicators in patients with COVID-19-associated lung damage, depending on the severity of the clinical course. Methodology. The study involved 75 patients with COVID-19, which, depending on the severity of lung involvement, were divided into two groups: patients with damage of up to 50 % of the lung parenchyma (n = 48) and with damage of more than 50 % (n = 27) respectively. The control group consisted of healthy people (n = 24), comparable in sex and age. In all individuals, the number of platelets, platelet aggregation induced by ADP, collagen and ristomycin were studied; polymorphisms rs6065 in the GP1BA gene, rs1126643 in the ITGA2 gene, and rs5918 in the ITGB3 gene were determined by polymerase chain reaction. The analysis of the obtained data was executed using the IBM SPSS Statistics v. 23 (IMB Corp., USA). Results and discussion. In patients with moderate and severe COVID-19-associated lung damage, platelet aggregation induced by ADP, collagen, and ristomycin accelerated; in severe cases, the number of platelets decreased. The frequency of variants of the rs6065 polymorphism did not change, the frequency of occurrence of the T/C genotype of the rs5918 polymorphism increased; with moderate severity, the frequency of occurrence of the C/T and T/T genotypes of the rs1126643 polymorphism increased; with severe lung damage, the frequency of occurrence of the mutant C/C genotype polymorphism rs5918 increased. In moderate lung damage, the presence of the mutant T/T polymorphism rs1126643 accelerated collagen-induced platelet aggregation; in severe cases, the presence of mutant C/C and heterozygous variant C/T polymorphism rs5918 accelerated ADP-induced platelet aggregation. There was no effect of the rs6065 polymorphism on platelet aggregation. The data obtained indicate the possible role of genetic predisposition in the activation of platelet aggregation in patients with COVID-19-associated lung damage.
Sex and age specificities of the dynamics of anthropometric indicators characterizing obesity (according to a prospective epidemiological research)
Authors: Tsygankova D. P. , Bazdyrev E. D. , Nakhratova O. V. , Tsenter I. M. , Gaziev T. F. , Indukaeva E. V. , Artamonova G. V. , Barbarash O. L. 
Published: January 2024

Background. Overweight and obesity significantly increase the risk of premature death and the development of chronic diseases. Many anthropometric indices have been developed to verify obesity, although the best among them still remains undetermined.The aim. To determine the sex and age specificities of the dynamics of anthropometric indicators characterizing obesity.Materials and methods. The program was implemented in the period from 2015 to 2020. It provided for the implementation of a sample research. The baseline research included 1,124 women and 476 men. The average age was 54.9 ± 9.75 years and 52.6 ± 10.0 years, respectively. To identify gender specificities, all participants were divided into three age groups: 35–49 years old, 50–59 years old, and 60–70 years old. The observation period was 3 years. To determine the level of visceral fat, the VS-532 fat mass analyzer (Tanita Health Equipment HK Ltd., Hong Kong) was used. Body mass index (BMI), waist-hip index (WV/HV), visceral obesity index (VOI) were also calculated. Statistical processing of the results was carried out using the program Statistica 6.0 (StatSoft Inc., USA).Results. New cases of obesity developed in 30.6 % of the surveyed. There was an increase in the prevalence of obesity according to the criteria of WV (by 8.9 %) and VFL (by 5.4 %) and a decrease in the number of people who are obese according to WV/HV – by 4.2 %. Of all the indicators, only VOI showed a statistically significant decrease in the mean values over the observed period, while BMI, WV and VFL showed an increase.Conclusions. It is necessary to apply various criteria for the diagnosis of obesity, since individual indices are not able to fully reflect the gender and age specificities of the distribution of fat in the body
Individual variability of higher mental functions in preschool children with regard to the material prosperity of the family (neuropsychological analysis)
Authors: Nerovnykh M. S. 
Published: January 2024

The problem of human individual development requires not just the accumulation and generalization of data, but also clarification, a systematic understanding of the individual variability of higher mental functions in relation to environmental factors and taking into account the risks associated with their formation.The aim: to identify systematic patterns of correlation between individual variability of higher mental functions of preschool children and the material prosperity of their families.Methods. Traditional neuropsychological tests developed by A.R. Luria and adapted in the neuropsychology laboratory of the Faculty of Psychology at Lomonosov Moscow State University were used. We examined 180 preschool children from families with high, average, and low income.Results. The greatest individual variability in the period of preschool age in relation to the level of material prosperity of the family, are the functions with a long period of formation, these are functions of block III of the brain, and the functions provided mainly by the left hemispheric parts of the brain. Children from the most affluent families have the highest indices of brain block III functions (p < 0.001) and left hemispheric functions (p < 0.001). Preschoolers from low-affluence families had indexes of both front brain function (p < 0.001) and left hemispheric function (p < 0.001) in the zone of negative values.Conclusion. The empirical results of the study allow us to clarify that the factor of material prosperity of the family, both directly, factor-wise, and indirectly, cumulatively, through the system of proximal factors, can make its selective contribution to the variability of indicators of children’s higher mental functions.
Assessment of consequences of COVID-19 in adolescents by the method of questionnaire
Authors: Cherevikova I. A. , Tkachuk E. A. , Polyakov V. M. , Vasileva N. S. , Prokhorova Zh. V. , Votineva A. S. , Myasishchev N. A. 
Published: January 2024

Background. In Russia, of all detected cases of COVID-19, 18 % were in the pediatric population. According to a number of studies, adolescents develop long-term clinical and psychological consequences after an illness. Therefore, at present, the most relevant is a thorough study of the structure and severity of consequences of COVID-19 in adolescents.The aim of the research was to assess the severity of consequences of COVID-19 in adolescents depending on the time period after diseases.Methods. The sample included 96 people aged 11–16 years: 48 adolescents who have undergone COVID-19 (main group); 48 adolescents who did not have COVID-19 (control group). The main group was divided into six subgroups, depending on the period after COVID-19. The following research methods were used: clinical history using a standardized interview method; “Correction test” method by B. Bourdon; Beck’s Depression Inventory (BDI-1A); Adolescent’s Form of Manifest Anxiety Scale by A.M. Prikhozhan.Results. Clinical symptoms of COVID-19 during the acute phase of the disease were considered in adolescents. It has been established that the most common symptoms include fever, runny nose, cough, sore throat, severe fatigue, impaired sense of smell, impaired taste, headache (most often localized in the frontal region). Clinical and psychological symptoms characteristic of post-COVID syndrome were considered as consequences of COVID-19 in adolescents. The majority of the examined adolescents showed the following clinical symptoms of COVID-19 after discharge: asthenia, disturbances of smell and taste; lasting from 2 to 64 weeks. As psychological symptoms, adolescents were characterized by reduced attention span, reduced speed of information processing and concentration, as well as the presence of symptoms of severe depression and high anxiety. During the second month after COVID-19, the most unfavorable emotional state was revealed in adolescents.Conclusions. The data obtained made it possible to determine that post-COVID syndrome in adolescents is characterized by the presence of an asthenic condition, impaired attention, high anxiety, severe depressive symptoms.
The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis
Authors: Batueva S. Yu. , Lamazhapova G. P. , Kapustina Yu. A. , Rodnaeva O. A. , Chukaev S. A. 
Published: January 2024

Background. The use of complexes of synthetic and herbal remedies as hepatoprotectors in the treatment of liver pathologies of various etiologies is an urgent task of pharmacology. A promising type of medicinal plant raw material is an extract of Hippophaes rhamnoides leaves. The hepatoprotective effect of extract of Hippophaes rhamnoides leaves in combination with ademethionine has not been studied to date.The aim of the research was to study changes in biochemical markers of hepatic function in the application of complex schemes of pharmacotherapy of experimental liver damage with paracetamol using Extractum foliorum Hippophaes rhamnoides.Materials and methods. The experimental study was performed on Wistar rats, the animals were divided into six groups. Group 1 (intact) – animals without a model of liver damage and without treatment; in Group 2 (control) paracetamol was used to create experimental hepatitis without treatment (positive control group); in Group 3 (comparison) a combination of “silibinin + ademethionine” was used on a model of paracetamol hepatitis; in Group 4 (experimental) extract of Hippophaes rhamnoides leaves was used on the model of paracetamol hepatitis; in Group 5 (experimental) ademethionine was used on a model of paracetamol hepatitis; in Group 6 (experimental) a combination of extract of Hippophaes rhamnoides leaves and ademethionine was used on a model of paracetamol hepatitis. The functional state of the liver of experimental animals was determined by biochemical parameters.Results. When using a combination of extract of Hippophaes rhamnoides leaves with ademethionine, the studied biochemical parameters significantly (p < 0.05) differed from the numerical values in the negative control group and were closest to those in the intact group than in other experimental groups.Conclusions. A comparison of the effectiveness of the use of extract of Hippophaes rhamnoides leaves in combination with ademethionine by the total effect on blood biochemical parameters determines this complex as a promising drug for further research.
Influence of alpha-glutamil-tryptophan on the background and induced activity of factors of adaptive immunity for prevention
Authors: Ruleva A. A. , Krasnov A. A. , Petlenko S. V. , Zaplutanov V. A. , Apryatina V. A. 
Published: January 2024

Background. During the ongoing COVID-19 pandemic and in the season of rising incidence of other respiratory infections, it is relevant to use preventive measures of non-specific prophylaxis. Synthetic peptides are widely considered as a tool. The representative of this group is the synthetic analogue of thymus regulatory peptides Thymogen, which has been used in Russia for more than 20 years in the treatment of acute and chronic infection diseases.The aim of the study. To evaluate the effect of Thymogen, a dosed nasal spray, on induced parameters of the immune system during prophylactic use in healthy volunteers.Materials and methods. Twenty healthy volunteers received Thymogen nasal dosed spray (JSC “Cytomed”, Russia) at a dose of 25 μg twice a day for 10 days. A comparative assessment of immunological parameters was carried out in dynamics: before the start of therapy, on days 6 and 11 of taking the drug and 14 days after the end of the course. Clinical observation was carried out from day 1 to day 11, registration of adverse events – the entire period of the study for 24 days. The first day was considered the day the drug was started.Results. In the course of the work, according to the data of immunological examination, a statistically significant increase in the virus-induced production of interferon alpha (INF-α) by a culture of peripheral blood cells was revealed. The growth rate was recorded on day 11 of taking Thymogen and persisted for 14 days after the end of the course. Significant differences in the dynamics of bactericidal and phagocytic activity of neutrophils, serum α- and γ-interferon were not obtained.Conclusion. The use of Thymogen spray at a dose of 25 μg for 10 days was safe and contributed to a significant induction of interferon-alpha in response to exposure to a viral pathogen, which allows us to recommend the drug for prophylactic use during the period of rising incidence of acute respiratory diseases.
Flu in children: Clinical, laboratory indicators and cytokine profile parameters
Authors: Kazantseva E. D. , Petrova A. G. , Darenskaya M. A. , Moskaleva E. V. , Rychkova L. V. , Semenova N. V. 
Published: January 2024

Introduction. Respiratory diseases occupy a leading place in the structure of pathology of childhood. The proportion of influenza and acute respiratory viral infections among all infectious diseases is 90 %. The literature describes gender differences in the immune response to respiratory infections in children, but there is a gap in the description of the cytokine profile in children with influenza depending on gender and age.The aim. To analyze clinical and laboratory parameters as well as cytokine profile parameters in children with influenza.Materials and methods. A single-stage descriptive study was conducted with the participation of 50 children from 1 to 11 years of age with a diagnosis of influenza who were on inpatient treatment at the Irkutsk Regional Infectious Diseases Clinical Hospital from December 2018 to January 2019. The clinical and laboratory features of the course of influenza in children, the duration of treatment were determined. The concentration of cytokines interleukin (IL) 1β, IL-4, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), interferon alpha and gamma (INF-α, INF-γ) in blood plasma was determined by enzyme-linked immunosorbent assay (ELISA) using diagnostic test systems manufactured by Vector-Best (Novosibirsk, Russian Federation) on the analyzer Multiscan EX (Thermo Electron, Germany).The control group consisted of practically healthy children without signs of acute respiratory viral infection (n = 50; mean age 5.3 ± 2.6 years).Results. When comparing clinical and laboratory data and cytokine profile parameters in children with influenza, no gender differences were found. There was a statistically significant increase in the level of pro-inflammatory cytokines IL-1β, IL-6, IL-8, TNF-α, INF-α, as well as CRP, anti-inflammatory cytokine IL-4 in influenza in all age categories, in contrast to the control group (p < 0.05).Conclusion. Influenza in children of different sexes proceeds classically without a statistical difference in clinical and laboratory parameters and in the level of cytokines.