bluuebunny/crossref_metadata_2025_split huggingface dataset:
Third-party retailer's lot-sizing policy under conditions of trade credit, uncertain demand and asymmetric initial budget information
Authors: Yang Hong , Li Lin , Liang Rui 
Published: September 2023

Abstract
Large retail platform has begun to provide trade credit to the capitalconstrained and start-up third party retailer (3PR). Most of the 3PRs face uncertain demands with few historical data, which makes it difficult for retail platform to evaluate the rationality of 3PR’s lot-sizing decision and to design trade credit contracts. In addition, and 3PR’s initial budget is unknown to the retail platform, which further increases the risk of trade credit. Therefore, this paper considers a two-echelon supply chain consisting of a retail-platform and a 3PR, and investigates the 3PR’s lot-sizing decision and the design of trade credit contract based on uncertain demand and asymmetric initial budget information. We find that 1) empirical uncertainty distribution is an effective tool for modeling uncertain demand with few historical data. 2) The 3PR will place an irrational purchasing order regardless of the market condition when the retail platform does not interfere with 3PR’s decision making. 3) The 3PR will overstate its initial budget to get more loan when the retail platform interferes with 3PR’s decision making.
Hypoxic glioma-derived exosomes induce the activation of astrocytes by promoting autophagy
Authors: Zhang Di , Tang Ziyi , Xue Zhiwei , Zhang Yan , Liu Xuchen , Zhao Jiangli , Liu Junzhi , Guo Qindong , Feng Bowen , Wang Jiwei , Li Xingang 
Published: September 2023

Abstract
The tumor microenvironment (TME) of glioma is formed by glioma cells and a series of surrounding cells, such as astrocytes, macrophages, T cells and neurons. In the TME, glioma cells can activate normal human astrocytes (NHAs) through the secretion of exosomes, and the activation of astrocytes can further improve the progression of glioma, leading to a poor prognosis for patients. However, the molecular mechanisms underlying glioma activation by NHAs are largely unknown.Here, we demonstrated that glioma-derived exosomes (GDEs) play an important role in the modulation of autophagy and activation of NHAs. Compared with normoxic glioma-derived exosomes (N-GDEs), hypoxic glioma-derived exosomes (H-GDEs) further improved autophagy and activation andstrongly promoted the proliferation and migration of glioma cells. In a miRNA array between two kinds of exosomes from glioma, we found that miR-423-3p was highly expressed in the H-GDEs, playedan important role in autophagy and resulted in the activation of NHAs. We identified the mechanism by which hypoxic glioma cells react with NHAsto create an immunosuppressive microenvironment. These findings provide new insight into the diagnosis and treatment of glioma by targeting autophagy or miR-423-3p.
The Effects of E-learning Using Educational Multimedia on the Ethical Decision-making and Professionalism of nursing students during the COVID-19 pandemic: a quasi-experimental study
Authors: Tavani Fatemeh Molaei , Behshid Mozhgan , Amini Abolghasem , Rahmani Azad , Rahmani Parvin , Mousavi Saeid 
Published: September 2023

Abstract

Background: The COVID-19 pandemic has created a great challenge for educational systems worldwide. During this time, educational centers have been encouraged to use distance learning programs to protect the population against infection. Online teaching has the greatest effect on the process of teaching-learning for certain topics, including professional behavior and commitment, which has prompted educational systems to use creative strategies for a greater effect on learners. The present study aims to determine the effects of e-learning using educational multimedia on the ethical decision-making and professionalism of nursing students during the COVID-19 pandemic.
Methods: This study was conducted using a quasi-experimental design with a control group. The statistical population comprised second-semester nursing students in a first-rank nursing school in north western Iran. The samples were selected using simple random sampling and were divided into experimental (n=40) and control (n=40) groups. In the first stage of teaching, the conventional training method of the COVID-19 pandemic was used in both groups. In the second stage of teaching, an in-person workshop was organized for the control group and an e-learning workshop using educational multimedia for the experimental group. Data were collected by a tool with three parts: Demographic information, the Nursing Dilemma Test (NDT) by Crisham based on the Nurse Principled Thinking, and the Nursing Students Professional Behaviors Scale (NSPBS) designed by Goz. Data were analyzed in SPSS 25 software.
Results: There was a statistically significant increase in the post-test mean score of professionalism (125.70±6.20 vs. 120.95±9.28) and ethical decision-making (46.17±3.81 vs. 44.02±3.21) in the experimental group compared to the control group (P<0.05).
Conclusion: The learning environment affects learning, and e-learning using educational multimedia has a greater impact than in-person workshops on improved learning outcomes with regard to ethical decision-making and professionalism.
Prediction of Carbapenem-Resistant Gram-Negative Bacterial Bloodstream Infection in Intensive Care Unit Based on Machine Learning
Authors: Liang Qiqiang , Ding Shuo , Chen Juan , Chen Xinyi , Xu Yongshan , Xu Zhijiang , Huang Man 
Published: September 2023

Abstract
Background: Predicting whether Carbapenem-Resistant Gram-Negative Bacterial (CRGNB) cause bloodstream infection when giving advice may guide the use of antibiotics because it takes 2-5 days conventionally to return the results from doctor's order.
Methods: It is a regional multi-center retrospective study in which patients with suspected bloodstream infections were divided into a positive and negative culture group. According to the positive results, patients were divided into the CRGNB group and other groups. We used the machine learning algorithm to predict whether the blood culture was positive and whether the pathogen was CRGNB once giving the order of blood culture.
Results: There were 952 patients with positive blood cultures, 418 patients in the CRGNB group, 534 in the non-CRGNB group, and 1422 with negative blood cultures. Mechanical ventilation, invasive catheterization, and carbapenem use history were the main high-risk factors for CRGNB bloodstream infection. The random forest model has the best prediction ability, with AUROC being 0.86, followed by the XGBoost prediction model in bloodstream infection prediction. In the CRGNB prediction model analysis, the SVM and random forest model have higher area under the receiver operating characteristic curves, which are 0.88 and 0.87, respectively.
Conclusions: The machine learning algorithm can accurately predict the occurrence of ICU-acquired bloodstream infection and identify whether CRGNB causes it once giving the order of blood culture.
Iguratimod in treatment of Rhupus Syndrome: A case report
Authors: zeng haiyan , li jin , jiali wang , fang He 
Published: September 2023

Abstract
BACKGROUND
Rhupus Syndrome is a rare condition sharing features of the rheumatoid arthritis and systemic lupus erythematosus. Current treatment strategies for patients with Rhupus are mainly based on a summary of existing case reports, clinical trial results, and retrospective cohort studies. However, there are few reports about the application of IGU in Rhupus Syndrome.
CASE SUMMARY
Here, we present the case of a patient with Rhupus Syndrome. The patient was initially diagnosed with systemic lupus erythematosus, subsequently, the patient developed synovitis with elevated RF and CCP titers and was finally diagnosed with Rhupus Syndrome. The patient was treated with IGU along with tofacitinib and prednisone and hydroxychloroquine, and to achieve disease remission.
CONCLUSION
IGU was effective for and well tolerated by our patient with Rhupus, and could be one of the drugs of choice to treat the disease.
Longitudinal study of functional connectivity changes in asymptomatic neurocognitive impairment(ANI) in HIV- infected patients
Authors: Ma Juming , Han Shuai , Hou Chuanke , Jiang Xingyuan , Xu Fan , Luo Haixia , Liu Jiaojiao , Wang Wei , Sun Lijun , Li Hongjun 
Published: September 2023

Abstract

Background: Asymptomatic neurocognitive impairment (ANI) stage is a critical stage for early diagnosis and treatment of HIV-associated neurocognitive disorder(HAND) disease, but there are few longitudinal studies on it. The changes of cognitive function and pathogenesis in HIV infected patients during this period remain unclear. Our objective was to evaluate changes in brain function after treatment in ANI patients based on amplitude of low frequency fluctuation(ALFF), amplitude of Low frequency fluctuation (fALFF), regional homogeneity(ReHo), and functional connectivity(FC) obtained by resting state functional magnetic resonance imaging(rs-fMRI).
Methods: The study involved follow-up of 49 ANI HIV infected patients who underwent two rs-fMRI and neurocognitive tests with an average interval of 1.26 years. The ALFF/fALFF, Reho and FC changes between baseline group and follow-up group were discussed. Subsequently, correlations between rs-fMRI results and cognitive and clinical variables were analyzed.
Results: Compared with baseline group, the follow-up group had a significant ReHo decrease in the left median cingulate and paracingulate gyri (DCG.L), right calcarine fissure and surrounding cortex (CAL.R), MOG.R and left precental gyrus(PreCG.L), as well as ReHo enhancement in the left supramarginal gyrus (SMG.L), right postcentral gyrus (PoCG.R), right parahippocampal gyrus(PHG.R) and left calcarine fissure and surrounding cortex (CAL.L)(FWE corrected, voxel-level P < 0.001, cluster-level P < 0.05). The results of ALFF/fALFF were not corrected by multiple comparisons, but decreased in MOG, supplementary motor area (SMA) and posterior central gyrus, and increased in amygdala and insula. The matrix diagram shows a statistically significant difference in connection reduction between CAL.L and PreCG.L and between CAL.R and MOG.RSome of the results of ReHo and FC were correlated with the results of cognitive tests.
Conclusion: These findings suggest that abnormalities in the cingulate gyrus, peritalate cortex, and anterior central gyrus may indicate disease progression and cognitive decline, while abnormalities in the occipital lobe, visual center, and related functional connections should be of more concern. However, the increase of ReHo and FC in some brain regions may mean that the cognitive changes in ANI patients under treatment may be complex
Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy with or without nimotuzumab in the treatment of locally advanced nasopharyngeal carcinoma: a retrospective study
Authors: yang zhi , zuo quan , liu rong , wu hui , xiong li , jia jieqi , xiang zhibi 
Published: September 2023

Abstract
Purpose
We aimed to investigate the efficacy and side effects of concurrent chemoradiotherapy, with or without nimotuzumab, for the treatment of locally advanced nasopharyngeal carcinoma after neoadjuvant chemotherapy.
Methods
This study retrospectively enrolled 109 patients with NPC from our hospital from July 2019 to May 2021.All patients were treated with TPF neoadjuvant chemotherapy for 2 cycles, and concurrent chemoradiotherapy was performed 2 weeks after chemotherapy. According to whether nimotuzumab was added in concurrent chemoradiotherapy, they were divided into the nimotuzumab group and the control group, with 52 cases in the nimotuzumab group and 57 cases in the control group.The efficacy and adverse reactions of the two groups were retrospectively analyzed.
Results
The objective remission and complete remission rates in the nimotuzumab and control groups were 100% vs 98.2% (p = 1.000), and 92.3% vs 78.9% (p = 0.049), respectively. The 3-year distant metastasis-free survival of the nimotuzumab and control groups was 91.6% and 77.3% (p = 0.047), respectively.The 3-year progression-free survival, locoregional relapse-free survival, and overall survival of the nimotuzumab and control groups were 87.6% vs 75.5% (p = 0.110), 90.5% vs 86.9% (p = 0.566), and 94.5% vs 87.1% (p = 0.295), respectively. In the nimotuzumab group, subgroup analysis showed that patients aged < 60 years (hazard ratio [HR] = 0.350, 95% confidence interval [CI]: 0.131–0.934, p = 0.036) and those with a granulocyte-to-lymphocyte ratio (grain/lymph ratio) ≤ 4 (HR = 0.365, 95% CI: 0.144–0.923, p = 0.033) achieved a better result. Additionally, multivariate analysis demonstrated that grain/lymph ratio was an independent risk factor for disease progression (HR = 7.485, p = 0.012) and distant metastasis (HR = 17.540, p = 0.009).
Conclusion
The concurrent chemoradiotherapy plus nimotuzumab after neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma achieved a higher complete remission rate and significantly improved distant metastasis-free survival compared with concurrent chemoradiotherapy alone. Additionally, an increasing trend was observed in progression-free survival, and the incidence of side effects was similar in both groups.
Beyond the Decade: Unveiling Long-Term Weight and Co-Morbidity Outcomes More Than 10 Years Post Laparoscopic Sleeve Gastrectomy
Authors: Sabah Salman Al , Haddad Eliana Al , Qadhi Iman , AlMuhaini Muneerah , AlAwtan Abrar , AlQabandi Omar A. , AlKhayat Ali , Saleem Ammar F. , Behbehani Mousa 
Published: September 2023

Abstract

Introduction
Despite its effectiveness, long-term outcomes of the safety and effectiveness of laparoscopic sleeve gastrectomy(LSG) for morbid obesity are still lacking.
Methods
We utilized phone interviews and hospital chart data for patients who underwent LSG, analyzing weight outcomes, comorbidities, and complications.
Results
The study included 2982 patients (72% female) with a maximum follow-up of 13 years. Mean pre-operative age and body mass index(BMI) were 34.7±11.3 years and 45.5±7.7 kg/m2. The prevalence of obesity classes were as follows: Class I, 3.1%; Class II, 19.2%; and Class III, 75.9%. BMI at nadir was 32.35 Kg/m2 equating to a mean nadir excess weight loss(EWL) of 67.03%. Weight outcomes at 13 years post-LSG showed a mean BMI of 31.83 kg/m2 and total weight loss(TWL) percentage of 31.43%. The highest excess weight loss and total weight loss were observed at 4 years and 18 months post-LSG, respectively. Weight loss outcomes varied according to pre-operative obesity class, with class I achieving the highest percentage EWL and class III observing the highest TWL at the end of one year. Weight regain occurred in 1.3% of the patient population, with class III experiencing the highest weight regain at 13 years. Significant reductions in comorbidities were observed, with a remission rate of 12.9% for type-1 DM. Complication rates were low, with 0.4% bleed, 0.5% leak, and 7.9% GERD.
Conclusion
LSG demonstrates sustained weight loss and comorbidity resolution, with low complication rates. The influence of initial obesity class on weight loss was significant only in the first 18 months post-LSG.
Memories of Early Eating Messages Transmitted by Caregivers and Their Relationship With Body Image and Eating Behavior in Adults
Authors: Ribeiro Júlio Cesar Bordignon , Cardoso Caroline Oliveira 
Published: September 2023

Abstract

Background: The development of eating behavior and body image are influenced by multiple factors. Among these factors, parents' attitudes toward their children's diet play an important role. However, there is a paucity of studies investigating whether dietary messages conveyed by parents in childhood also have an impact on eating behavior and body image perception in adulthood. As a result, the objective of the present study was to verify the relationship and impact of memories of early food messages with the appreciation of body image and the eating behavior of adults, as well as to investigate the impact of memories of food messages, years of study, socioeconomic level, gender, age and emotional symptoms on eating behavior and appreciation of body image.
Methods: The study included 279 adults who completed a sociodemographic questionnaire, the Caregiver Eating Messages Scale Body Appreciation Scale, the Intuitive Eating Scale 2 and the Depression Anxiety and Stress Scale.
Results: The results revealed that critical and restrictive messages and pressure to eat messages seem to be related to eating behavior and appreciation of body image, with significant associations, although of weak magnitude. Furthermore, through regression analysis, it was found that the variables of critical and restrictive eating messages, along with the level of depression, seem to have a more significant impact on eating behavior and body image in adult life.
Conclusions:This study has clinical implications, as it highlights the association between early control eating messages and possible outcomes in adult life. This highlights the importance of implementing educational programs aimed at parents to promote adaptive strategies regarding food control.
Trial registration: The project was approved on July 4, 2022 by the Research Ethics Committee of Feevale University, in Novo Hamburgo, under number CAAE 58617722.9.0000.5348.
Prevention of Cancer - Melanoma Development and Its Diagnosis Among Silesian Voivodeship Residents - Preliminary Results
Authors: Dąbek Józefa , Żerdka Julia , Brasse Patryk 
Published: September 2023

Abstract
Background
Melanoma is a malignant tumor with the highest growth rate in the incidence and is the leading cause of death due to skin cancers.
In Poland, approximately 1500 cases of melanoma are detected annually in advanced or metastatic stages. Intensive preventive measures can contribute to its early-stage diagnosis, consequently reducing the number of fatalities.
The aim of the study was to assess the occurrence of melanoma risk factors among the residents of Silesia region and their knowledge about the diagnosis and prevention of this cancer.
Methods
The study was conducted among the residents of the Silesian voivodeship. A total of 400 (100%) individuals were examined. Among them were 243 women and 157 men. The participants' ages ranged from 16 to 84 years (mean age = 34.38±18.39).
An original questionnaire was used in the study, and its completion was anonymous and voluntary. The questions included in it pertained to the discussed topic as well as general data, such as age, gender, place of residence, and occupation.
Results
The participants were burdened with melanoma development risk factors such as fair skin complexion (236; 58.71%), having more than 50 pigmented lesions (159; 39.55%), sunburns (106; 26.37%), family history of melanoma (60; 14.93%), and tanning salon use (32; 7.96%).
Over 40% (173; 43.03%) of the participants had never examined their pigmented lesions. A staggering 80% (322; 80.1%) of the respondents had never undergone dermatoscopic examination, and over 50% (214; 53.23%) did not know what this examination entailed. Just under 16% (63; 15.67%) of the participants stated that their family doctor had examined their pigmented lesions, and almost 90% (140; 88.05%) of those with numerous pigmented lesions had never been referred to a dermatologist for dermatoscopy.
Conclusions
The surveyed residents of the Silesian Voivodeship were burdened with numerous risk factors for melanoma development, with the most common being fair skin complexion, having more than 50 pigmented lesions, and sunburns.
The knowledge of the participants regarding the diagnosis and prevention of melanoma development was insufficient, thus highlighting the necessity for conducting systematic educational initiatives in the mentioned field. These initiatives should ultimately lead to the preservation of health and life, as well as the maintenance of its high quality.
Trial registration
Not applicable.
The Contribution of Low Apgar Scores in Identifying Neonates with Short-term Morbidities in a Large Single Center Cohort
Authors: Rozycki Henry , Huang Samuel , yitayew Miheret 
Published: September 2023

Abstract
Objective
To evaluate the association and utility of low 1- and 5-minute Apgar scores to identify short-term morbidities in a large newborn cohort.
Methods
15,542 infants > 22 weeks gestation from a single center were included. Clinical data and low Apgar scores were analyzed for significance to 10 short-term outcomes and were used to construct Receiver Operating Characteristic Curves and the area under the curve (AUC) calculated for 10 outcomes.
Results
A low Apgar score related to all (1-minute) or most (5-minute) outcomes by univariate and multivariate logistic regression analysis. Including any of the 4 low Apgar scores only improved the clinical factor AUC by 0.9% ± 2.7% (± SD) and was significant in just 5 of the 40 score/outcome scenarios.
Conclusion
The contribution of a low Apgar score for identifying risk of short-term morbidity does not appear to be clinically significant.
Circular RNA hsa_circ_0001846 facilitates the malignant behaviours of pancreatic cancer by sponging miR-204-3p and upregulating KRAS expression.
Authors: Qiao Guofen , Ma Xiaolei , Zhang Haocheng , Wang Luning , Cheng Mengxing , Jia Yanxin , Feng Di , Lei Yating , Li Xinyu , Ba Lina , Song Na , Yang Xinxia , Bai Lidan , Zhang Ruipu , Xu Wenxiao 
Published: September 2023

Abstract
Pancreatic cancer (PC) is mainly derived from the exocrine pancreatic ductal epithelial cells, and it is strongly aggressive malignant tumor. Due to its insidious onset and the lack of effective diagnostic biomarkers, PC currently remains one of the main causes of cancer-related mortality worldwide. Recent studies have found that hsa_circ_0001846 is involved in the progression of multiple cancers and has the potential to become biomarkers, but its function and mechanism in pancreatic cancer remains unclear. We found by qRT-PCR experiments that hsa_circ_0001846 was upregulated in pancreatic cancer cells and tissues, while circBase, Sanger sequencing, agarose gel electrophoresis and FISH experiments identified the splicing site, ring structure and cellular localization of hsa_circ_0001846. Various functional experiments by using the construction of small interfering RNA targeting hsa_circ_0001846 and overexpression plasmid demonstrated that hsa_circ_0001846 promoted the proliferation, migration and invasion of PC cells. Moreover, the tumor weight and volume of nude mice were significantly reduced after the stable knockdown of hsa_circ_0001846. In the mechanism exploration, RNA pull-down experiments and dual luciferase experiments helped us to determine that hsa_circ_0001846 regulated the KRAS expression by sponging miR-204-3p in PC, thus playing a pro-cancer role. In this study, the effect of miR-204-3p on pancreatic cancer was also explored for the first time, and we found that knockdown of miR-204-3p reversed the tumor suppressive effect caused by silencing hsa_circ_0001846, and silencing KRAS also rescued the pro-cancer effect caused by overexpression of hsa_circ_0001846. In conclusion, our study revealed the pro-cancer role of hsa_circ_0001846 in PC, and for the first time identified the mechanism that hsa_circ_0001846 regulated KRAS by sponging miR-204-3p to promote PC progression and had the potential to become a cancer biomarker.