bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of predicting maximal oxygen uptake by using the efficiency factor in healthy men
Authors: Li Fang , Tu Yu-Tsai , Yeh Hung-Chih , Ho Chia-An , Yang Cheng-Pang , Kuo Ying-Chen , Ho Chin-Shan 
Published: October 2023

AbstractConventionally, efficiency is indirectly estimated through a respiratory gas analyser (oxygen, carbon dioxide), which is a complex and rather costly calculation method that is difficult to perform in many situations. Therefore, the present study proposed a modified definition of efficiency, called the efficiency factor (EF) (i.e., the ratio of work to the corresponding exercise intensity), and evaluated the relation between the EF and maximal oxygen uptake ($${\dot{\text{V}}\text{O}}_{2\max }$$

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), as well as compared the prediction models established based on the EF. The heart rate (maximal heart rate: 186 ± 6 beats min−1), rating of perceived exertion (19 ± 1), and $${\dot{\text{V}}\text{O}}_{2\max }$$

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(39.0 ± 7.1 mL kg−1 min−1) of 150 healthy men (age: 20 ± 2 years; height: 175.0 ± 6.0 cm; weight: 73.6 ± 10.7 kg; body mass index [BMI]: 24.0 ± 3.0 kg m−2; percent body fat [PBF]: 17.0 ± 5.7%) were measured during the cardiopulmonary exercise test (CPET). Through multiple linear regression analysis, we established the BMI model using age and BMI as parameters. Additionally, we created the PBF modelHRR utilizing weight, PBF, and heart rate reserve (HRR) and developed PBF modelEF6 and PBF modelEF7 by incorporating EF6 from the exercise stage 6 and EF7 from the exercise stage 7 during the CPET, respectively. EF6 (r = 0.32, p = 0.001) and EF7 (r = 0.31, p = 0.002) were significantly related to $${\dot{\text{V}}\text{O}}_{2\max }$$

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. Among the models, the PBF modelEF6 showed the highest accuracy, which could explain 62.6% of the variance in the $${\dot{\text{V}}\text{O}}_{2\max }$$

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at with a standard error of estimate (SEE) of 4.39 mL kg−1 min−1 (%SEE = 11.25%, p < 0.001). These results indicated that the EF is a significant predictor of $${\dot{\text{V}}\text{O}}_{2\max }$$

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, and compared to the other models, the PBF modelEF6 is the best model for estimating $${\dot{\text{V}}\text{O}}_{2\max }$$

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Macrophage depletion attenuates degeneration of spiral ganglion neurons in kanamycin-induced unilateral hearing loss model
Authors: Shimada Mari Dias , Noda Masao , Koshu Ryota , Takaso Yuji , Sugimoto Hisashi , Ito Makoto , Yoshizaki Tomokazu , Hori Osamu 
Published: October 2023

AbstractPathological conditions in cochlea, such as ototoxicity, acoustic trauma, and age-related cochlear degeneration, induce cell death in the organ of Corti and degeneration of the spiral ganglion neurons (SGNs). Although macrophages play an essential role after cochlear injury, its role in the SGNs is limitedly understood. We analyzed the status of macrophage activation and neuronal damage in the spiral ganglion after kanamycin-induced unilateral hearing loss in mice. The number of ionized calcium-binding adapter molecule 1 (Iba1)-positive macrophages increased 3 days after unilateral kanamycin injection. Macrophages showed larger cell bodies, suggesting activation status. Interestingly, the number of activating transcription factor 3 (ATF3)-positive-neurons, an indicator of early neuronal damage, also increased at the same timing. In the later stages, the number of macrophages decreased, and the cell bodies became smaller, although the number of neuronal deaths increased. To understand their role in neuronal damage, macrophages were depleted via intraperitoneal injection of clodronate liposome 24 h after kanamycin injection. Macrophage depletion decreased the number of ATF3-positive neurons at day 3 and neuronal death at day 28 in the spiral ganglion following kanamycin injection. Our results suggest that suppression of inflammation by clodronate at early timing can protect spiral ganglion damage following cochlear insult.
Education loan repayment: a systematic literature review
Authors: Bhandary Rakshith , Shenoy Sandeep S. , Shetty Ankitha , Shetty Adithya D. 
Published: October 2023

AbstractEducation is a significant contributor to human capital. Financial assistance for education through institutional loan serves as the key element for human development, and loan repayment without default makes the education loan product self-sustainable. The systematic review aims to study the various articles related to education loan repayment (ELR) using bibliometric analysis approach and R studio software with the help of biblioshiny package. The study analyses 812 articles published in the Scopus database between 1990 and 2022. The review identifies most relevant authors, most cited articles, publication trends, keywords and themes, and trending topics. The review finds that research in the domain of ELR is at an increasing trend with a growth rate of 7.2% and, in the year 2022, the highest number of scientific publications, that is, 72 articles, was published. The review exhibits that existing research in the field has mainly focused on themes such as repayment burden, financial literacy, financial education, student debt, income, mental health, and loan defaults. The study concludes that highly cited work in educational loan repayment is in the field of medicine, highlighting salary as the key factor for educational loan repayment, and loan repayment is incentivized by the federal government to serve the designated underserved areas through service option loan repayment programs. Methods on designing and marketing new approaches to loan repayment can be researched in future with relation to human resource recruitment and retention by the employers.
Synthesis and characterization of XeAr2 under high pressure
Authors: Wang Mengnan , Kuzovnikov Mikhail A. , Binns Jack , Li Xiaofeng , Peña-Alvarez Miriam , Hermann Andreas , Gregoryanz Eugene , Howie Ross T. 
Published: October 2023

The binary Xe–Ar system has been studied in a series of high pressure diamond anvil cell experiments up to 60 GPa at 300 K. In-situ x-ray powder diffraction and Raman spectroscopy indicate the formation of a van der Waals compound, XeAr2, at above 3.5 GPa. Powder x-ray diffraction analysis demonstrates that XeAr2 adopts a Laves MgZn2-type structure with space group P63/mmc and cell parameters a = 6.595 Å and c = 10.716 Å at 4 GPa. Density functional theory calculations support the structure determination, with agreement between experimental and calculated Raman spectra. Our DFT calculations suggest that XeAr2 would remain stable without a structural transformation or decomposition into elemental Xe and Ar up to at least 80 GPa.
Comparison of classical and ab initio simulations of hydronium and aqueous proton transfer
Authors: Maurer Manuela , Lazaridis Themis 
Published: October 2023

Proton transport in aqueous systems occurs by making and breaking covalent bonds, a process that classical force fields cannot reproduce. Various attempts have been made to remedy this deficiency, by valence bond theory or instantaneous proton transfers, but the ability of such methods to provide a realistic picture of this fundamental process has not been fully evaluated. Here we compare an ab initio molecular dynamics (AIMD) simulation of an excess proton in water to a simulation of a classical H3O+ in TIP3P water. The energy gap upon instantaneous proton transfer from H3O+ to an acceptor water molecule is much higher in the classical simulation than in the AIMD configurations evaluated with the same classical potential. The origins of this discrepancy are identified by comparing the solvent structures around the excess proton in the two systems. One major structural difference is in the tilt angle of the water molecules that accept an hydrogen bond from H3O+. The lack of lone pairs in TIP3P produces a tilt angle that is too large and generates an unfavorable geometry after instantaneous proton transfer. This problem can be alleviated by the use of TIP5P, which gives a tilt angle much closer to the AIMD result. Another important factor that raises the energy gap is the different optimal distance in water-water vs H3O+-water H-bonds. In AIMD the acceptor is gradually polarized and takes a hydronium-like configuration even before proton transfer actually happens. Ways to remedy some of these problems in classical simulations are discussed.
Convexification for the viscocity solution for a coefficient inverse problem for the radiative transfer equation
Authors: Klibanov Michael V , Li Jingzhi , Yang Zhipeng 
Published: October 2023

Abstract
A coefficient inverse problem for the radiative transport equation is considered. The globally convergent numerical method, the so-called convexification, is developed. For the first time, the viscosity solution is considered for a boundary value problem for the resulting system of two coupled partial differential equations. A Lipschitz stability estimate is proved for this boundary value problem using a Carleman estimate for the Laplace operator. Next, the global convergence analysis is provided via that Carleman estimate. Results of numerical experiments demonstrate a high computational efficiency of this approach.
Fault detection and localization in unshielded twisted pair cable based on observability analysis and reflectometry experimental measurements
Authors: Idellette Judith Hermine Som , Cocquempot Vincent , Degardin Virginie 
Published: October 2023

Abstract
In this paper, an efficient method is proposed for detecting and locating a soft fault, i.e. a physical degradation, in a Y-shaped network of unshielded twisted pair cables. The method uses jointly the observability analysis and time-frequency domain reflectometry experimental measurements. The fault detection consists in checking the consistency between the known characteristics of the cable under no-fault and faulty conditions, with the maximum value of a normalized time-frequency cross-correlation function computed on a sliding time window whose length is equal to the boundary exact observability time. The cable transmission speed and the wired network observability time are combined to locate precisely the fault. Soft faults are artificially created by connecting resistors of different values to the test cable. Experimental results show the efficiency of our fault detection and localization method.
Energy in critical collapse
Authors: Hu Yu , Guo Jun-Qi , Li Junbin , Shao Cheng-Gang , Zhang Hongsheng 
Published: October 2023

AbstractWe study the energy issue in critical collapse. It is found that in critical collapse, the contribution from the material energy is greater than that from the gravitational energy. The quantitym/rplays an important role in identifying the formation of an apparent horizon in gravitational collapse, wheremis the Misner–Sharp mass andr is the areal radius. We observe that in critical collapse, the maximum value ofm/rfluctuates between 2/15 and 4/15. This denotes a large gap between critical collapse and black hole formation for which the criterion ism/r= 1/2.
One-dimensional run-and-tumble motions with generic boundary conditions
Authors: Angelani Luca 
Published: October 2023

Abstract
The motion of run-and-tumble particles in one-dimensional finite domains are analyzed in the presence of generic boundary conditions. These describe accumulation at walls, where particles can either be absorbed at a given rate, or tumble, with a rate that may be, in general, different from that in the bulk. This formulation allows us to treat in a unified way very different boundary conditions (fully and partially absorbing/reflecting, sticky, sticky-reactive and sticky-absorbing boundaries) which can be recovered as appropriate limits of the general case. We report the general expression of the mean exit time, valid for generic boundaries, discussing many case studies, from equal boundaries to more interesting cases of different boundary conditions at the two ends of the domain, resulting in nontrivial expressions of mean exit times.
Tofacitinib for Patients with Anti-TNF Refractory Ulcerative Proctitis: A Multicentre Cohort Study from the GETAID
Authors: Uzzan Mathieu , Nachury Maria , Nuzzo Alexandre , Amiot Aurélien , Caron Bénédicte , Benezech Alban , Buisson Anthony , Bouguen Guillaume , Le Berre Catherine , Reenaers Catherine , Le Cosquer Guillaume , Savoye Guillaume , Charkaoui Maeva , Vidon Mathias , Guillo Lucas , Fumery Mathurin , Peyrin-Biroulet Laurent , Kirchgesner Julien , Bouhnik Yoram ,   GETAID TOFA-PRO study group, Fumery Mathurin , Yzet Clara , Brazier Franck , Billiauws Lore , Bouhnik Yoram , Nuzzo Alexandre , Amiot Aurélien , Carbonnel Franck , Bresteau Clément , Meyer Antoine , Bellanger Christophe , Nachury Maria , Wils Pauline , Desreumaux Pierre , Branche Julien , Gérard Romain , Assaraf Julie , Gagnière Charlotte , Uzzan Mathieu , Beaugerie Laurent , Sokol Harry , Seksik Philippe , Bourrier Anne , Kirchgesner Julien , McLellan Paul , Le Cosquer Guillaume , Gilletta Cyrielle , Caron Bénédicte , Peyrin-Biroulet Laurent , Guilmoteau Thomas , Dodel Marie , Coban Dilek , Bouhnik Yoram , Cohen Mathilde , Treton Xavier , Guillo Lucas , Serrero Mélanie 
Published: October 2023

Abstract

Background
Although ulcerative proctitis [UP] can dramatically impair quality of life, treatment efficacy has been poorly investigated in UP as it was historically excluded from phase 2/3 randomised controlled trials in ulcerative colitis. Our aim was to assess the effectiveness and safety of tofacitinib for the treatment of UP.

Methods
We conducted a retrospective, multicentre study in 17 GETAID centres, including consecutive patients with UP treated with tofacitinib. The primary endpoint was steroid-free remission between Week 8 and Week 14, defined as a partial Mayo score of 2 [and no individual subscore above 1]. Secondary outcomes included clinical response and steroid-free remission after induction and at 1 year.

Results
All the 35 enrolled patients previously received anti-tumour necrosis factor [TNF] therapy and 88.6% were exposed to at least two lines of biologics. At baseline, the median partial Mayo score was 7 (intequartile range [IQR] [5.5-7]). After induction [W8-W14], 42.9% and 60.0% of patients achieved steroid-free remission and clinical response, respectively. At 1 year, the steroid-free clinical remission and clinical response rates were 39.4% and 45.5%, respectively, and 51.2% [17/33] were still receiving tofacitinib treatment. Survival without tofacitinib withdrawal was estimated at 50.4% (95% confidence interval [CI] [35.5-71.6]) at 1 year. Only a lower partial Mayo at baseline was independently associated with remission at induction (0dds ratio [OR] = 0.56 for an increase of 1, (95% CI [0.33-0.95], p = 0.03). Five [14.3%] adverse events were reported, with one leading to treatment withdrawal [septic shock secondary to cholecystitis].

Conclusion
Tofacitinib may offer a therapeutic option for patients with refractory UP.
In vitro regulation of fibroblast growth factor 23 by 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D synthesized by osteocyte-like MC3T3-E1 cells
Authors: Ratsma Danielle M A , Muller Max , Koedam Marijke , Zillikens M Carola , van der Eerden Bram C J 
Published: October 2023

Abstract
Fibroblast growth factor 23 (FGF23) is produced and secreted by osteocytes and is essential for maintaining phosphate homeostasis. One of the main regulators of FGF23, 1,25-dihydroxyvitamin D (1,25(OH)2D3), is primarily synthesized in the kidney from 25-hydroxyvitamin D (25(OH)D) by 1α-hydroxylase (encoded by CYP27B1). Hitherto, it is unclear whether osteocytes can convert 25(OH)D and thereby allow for 1,25(OH)2D3 to induce FGF23 production and secretion locally. Here, we differentiated MC3T3-E1 cells toward osteocyte-like cells expressing and secreting FGF23. Treatment with 10−6 M 25(OH)D resulted in conversion of 25(OH)D to 150 pmol/L 1,25(OH)2D3 and increased FGF23 expression and secretion, but the converted amount of 1,25(OH)2D3 was insufficient to trigger an FGF23 response, so the effect on FGF23 was most likely directly caused by 25(OH)D. Interestingly, combining phosphate with 25(OH)D resulted in a synergistic increase in FGF23 expression and secretion, likely due to activation of additional signaling pathways by phosphate. Blockage of the vitamin D receptor (VDR) only partially abolished the effects of 25(OH)D or 25(OH)D combined with phosphate on Fgf23, while completely inhibiting the upregulation of cytochrome P450 family 24 subfamily A member 1 (Cyp24a1), encoding for 24-hydroxylase. RNA sequencing and in silico analyses showed that this could potentially be mediated by the nuclear receptors Retinoic Acid Receptor β (RARB) and Estrogen Receptor 2 (ESR2). Taken together, we demonstrate that osteocytes are able to convert 25(OH)D to 1,25(OH)2D3, but this is insufficient for FGF23 activation, implicating a direct effect of 25(OH)D in the regulation of FGF23, which occurs at least partially independent from its cognate VDR. Moreover, phosphate and 25(OH)D synergistically increase expression and secretion of FGF23, which warrants investigating consequences in patients receiving a combination of vitamin D analogues and phosphate supplements. These observations help us to further understand the complex relations between phosphate, vitamin D, and FGF23.
The lithosphere–asthenosphere boundary structure at 11–21 Ma from wide-angle seismic data in the equatorial Atlantic Ocean
Authors: Vaddineni Venkata A , Singh Satish C 
Published: October 2023

SUMMARYThe lithosphere–asthenosphere boundary (LAB) separates the rigid lithospheric plate above with the ductile and convective asthenosphere below and plays a fundamental role in plate tectonic processes. The LAB has been imaged using passive geophysical methods, but these methods only provide low-resolution images. Recently, seismic reflection imaging method has provided high-resolution images of the LAB, but imaging of the LAB at younger ages has been difficult. Here, we present the image of the LAB using wide-angle seismic reflection data covering 11–21 Ma old lithosphere in the equatorial Atlantic Ocean. Using ocean bottom seismometers (OBSs), we have observed wide-angle reflections between 150 and 400 km offsets along with crustal and mantle refraction arrivals. We first performed traveltime tomography to obtain the velocity in the crust and upper mantle. The Pn arrivals provide the information about P-wave velocity down to 4 km below the Moho. The disappearance of Pn arrivals beyond 130 km offset suggests that vertical P-wave velocity gradient is negligible or negative below this depth. We extended these velocities down to 90 km depth and then applied two imaging techniques to wide-angle reflection data, namely traveltime mapping of picked reflection arrivals and pre-stack depth migration of full wavefield data. We find that these reflections originate between 34 and 67 km depth, possibly from the LAB system. We have carried out extensive modelling to show that these reflections are real and not artefacts of imaging. Comparison of our results with coincident passive seismological and magnetotelluric results suggests that wide-angle imaging technique can be successfully used to study the lithosphere and the LAB system. We find that the LAB gradually deepens with age, but becomes very deep at 17–19 Ma, which we interpret to be due to the anomalous geology along this part of the profile.
Cultural and translation challenges in assessing health literacy among immigrants from the former Soviet Union
Authors: Shaw Susan J , Huebner Torres Cristina , Lee Jeannie K , Gavrilyuk Dina , Korchmaros Josephine D 
Published: October 2023

Abstract
Health literacy is an important foundation for health promotion and an under-recognized risk factor for immigrant and refugee groups. Yet measuring health literacy among diverse ethnic and linguistic populations presents complex challenges. We describe cultural and translation challenges encountered in measuring health literacy among Russian-speaking immigrants to the USA and offer a mixed-methods approach to understanding them. The Rx-Health Literacy (RxHL) study used cross-sectional quantitative and qualitative data to examine health literacy and medication adherence among five cultural and four language groups (Latinx, Vietnamese, African-American, Russian-speaking immigrant and White American) who are patients at Caring Health Center, a federally qualified health center in Springfield, MA. We translated an existing health literacy scale into Russian and Vietnamese and examined item difficulty across cultural groups. We conducted qualitative cognitive interviews to learn more about Russian speakers’ understandings of the scale. Health literacy scores varied by cultural group, and the range of correct responses was much greater among Russian speakers than in other groups. Percentage correct varied by 69.7% for Russian speakers, compared with 25.0–44.0% for other groups. These findings indicate greater variability in health literacy levels among this group compared with others. Cognitive interviews with Russian-speaking participants revealed multiple interpretations of several items, suggesting that the English version of the scale contained embedded meanings associated with an American health care context that were not captured in the translated instrument. Combining qualitative and quantitative research methods allows for greater insight into contextual and translation factors that may shape the results of translated instruments in unanticipated ways.
Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study
Authors: Goutelle Sylvain , Jullien Vincent , Bru Jean-Pierre , Cattoir Vincent , Gauzit Rémy , Lesprit Philippe , Lina Gérard , Schramm Frédéric , Canoui Etienne , Lepeule Raphael 
Published: October 2023

Abstract

Background
The new definitions of antimicrobial susceptibility categories proposed by EUCAST in 2020 require the definition of standard and high dosages of antibiotic. For injectable β-lactams, standard and high dosages have been proposed for short-infusion regimens only.

Objectives
To evaluate dosages for β-lactams administered by prolonged infusion (PI) and continuous infusion (CI).

Methods
Monte Carlo simulations were performed for seven injectable β-lactams: aztreonam, cefepime, cefotaxime, cefoxitin, ceftazidime, piperacillin and temocillin. Various dosage regimens based on short infusion, PI or CI were simulated in virtual patients. Pharmacokinetic (PK) profiles and PTAs were obtained based on reference population PK models, as well as PK/pharmacodynamic targets and MIC breakpoints proposed by EUCAST. Alternative dosage regimens associated with PTA values similar to those of recommended dosages up to the breakpoints were considered acceptable.

Results
Adequate PTAs were confirmed for most EUCAST short-infusion dosage regimens. A total of 9 standard and 14 high dosages based on PI (3 to 4 h) or CI were identified as alternatives. For cefepime and aztreonam, only PI and CI regimens could achieve acceptable PTAs for infections caused by Pseudomonas spp.: 2 g q8h as PI of 4 h or 6 g/24 h CI for cefepime; 2 g q6h as PI of 3 h or 6 g/24 h CI for aztreonam.

Conclusions
These alternative standard and high dosage regimens are expected to provide antibiotic exposure compatible with new EUCAST definitions of susceptibility categories and associated MIC breakpoints. However, further clinical evaluation is necessary.