bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are strategy developers well equipped when designing sustainable supply chains for a circular bio-economy? Supporting innovations’ market uptake in a PESTEL + I environment
Authors: Blümel Linda , Siegfried Konrad , Riedel Fabian , Thrän Daniela 
Published: November 2023

Abstract
Background
Innovations and new supply chain concepts are crucial for establishing a sustainable and circular bio-economy that reduces carbon emissions and lowers negative environmental impacts. PESTEL-based concept development provides information about positive, negative and neutral external factors of the macro-environment and their influence on supply chains. The primary data were collected at a stakeholder workshop and gaps in understanding the critical details were closed through expert interviews. The information gathered was organised using a data management software and coded by following a deductively formed system based on predefined PESTEL categories (political, economic, social, technological, ecological, legal). Stakeholders that used the method on intermediate carbon carriers (ICC) grappled with identifying the obstacles that hinder the market uptake of innovations. The workshop revealed a substantial demand for additional information. Infrastructural aspects were considered key to adequately understanding all of the segments along a supply chain. Using PESTEL alone, without taking infrastructural aspects into consideration, meant that the macro-environment that surrounds and affects the ICC supply chain remained a black box. This paper developed docking-related approaches to the basic PESTEL method in order to improve its output for the development of strategic concepts and to improve the market uptake of bio-economy-centred innovations.

Results
The expanded PESTEL method (hereinafter PESTEL + I) significantly shifted the emphasis of strategic decisions to the marketing of individual innovations compared to the basic method. Docking information gathering onto infrastructure (+ I) should be considered in order to expand existing strategy development concepts for bio-economy value chains. Testing the market uptake of innovations was beyond the scope of this study.

Conclusions
PESTEL + I not only increased the utility, but also the complexity and the time needed to analyse an entire supply chain. The expanded method, however, provides stakeholders and strategy developers with a more useful tool to support and optimise market uptake strategies in the bio-economy. Beyond this, there is a knowledge gap with regard to reducing the effort needed to collect data and evaluate such studies. Hence, follow-up research needs to find ways to digitalise major steps in the overall process to make it more efficient.
Vitamin D and hypophosphatemia in patients with anorexia nervosa and avoidant/restrictive food intake disorder: a case control study
Authors: Kells Meredith R. , Roske Chloe , Watters Ashlie , Puckett Leah , Wildes Jennifer E. , Crow Scott J. , Mehler Philip S. 
Published: November 2023

Abstract
Background
Refeeding hypophosphatemia (RH) is a common complication of nutritional restoration in malnourished individuals, yet clear risk stratification remains elusive. Individuals with anorexia nervosa (AN) and avoidant/restrictive food intake disorder (ARFID) may be deficient in vitamin D, an important component of dietary phosphorus absorption in the gut. The relationship between vitamin D and RH in AN and ARFID is unknown. Therefore, the aims of this study were to (1) report rates of low serum 25-hydroxy vitamin D and RH in AN and ARFID; (2) describe associations between phosphorus and variables associated with RH identified in extant literature; (3) examine the relationship between 25-hydroxy vitamin D and RH and (4) investigate moderation by vitamin D between variables of interest and phosphorus level.

Method
Analyses included retrospective chart review of 307 individuals admitted to the ACUTE Center for Eating Disorders and Severe Malnutrition with a diagnosis of AN or ARFID. Variables of interest included admission laboratory values (vitamin D level, comprehensive metabolic panel, hemoglobin, point-of-care blood glucose), anthropometric measures (weight, body mass index [BMI], % ideal body weight [IBW]), age, duration of illness, length of stay, feeding method, and serum phosphorus nadir. Pearson and Spearman rank correlation, one-way ANOVA, and regression analyses were used to determine the relationship between variables and serum phosphorus.

Results
Over 1/3 of the sample (35.3%) had serum phosphorus levels ≤ 2.9 mg/dL. There were no significant differences between groups in phosphorus nadir (p = .17, η2 = 0.12) or hypophosphatemia (p = .16, ϕc = 0.11). Thirty-five (35%) of individuals with ARFID were either deficient or insufficient in vitamin D, compared to 29% of individuals with AN. Individuals with AN had significantly higher mean vitamin D levels compared to those with ARFID (p = .03; η2 = 0.015). Nadir phosphorus showed a positive association with weight, BMI, %IBW, potassium, and calcium on admission, and a negative association with length of stay, hemoglobin, and total number of tube-fed days. Higher levels of 25-hydroxy vitamin D moderated the relationship between serum phosphorus nadir and weight on admission (p = .0004).

Conclusion
Individuals diagnosed with ARFID are as nutritionally fragile as those with AN regarding vitamin D and RH. The negative feedback loop involving vitamin D that maintains phosphorus homeostasis may play a role in the development of RH in AN and ARFID.
Advantages and limitations of micro-computed tomography and computed tomography imaging of archaeological textiles and coffins
Authors: Lipkin Sanna , Karjalainen Ville-Pauli , Puolakka Hanna-Leena , Finnilä Mikko A. J. 
Published: November 2023

Abstract
We have recently studied northern Finnish archaeological textiles extensively using computed tomography (CT) imaging. These textiles have been found in inhumation burials from the Late Medieval church of Valmarinniemi in Keminmaa and the Postmedieval church of Haukipudas. In this article we discuss the advantages and limitations of CT imaging based on three case studies. Based on the research objectives and the size of studied items, we utilised three different CT scanners: clinical systems and micro- and nano-scale X-ray microscopes. We were able to visualise a child’s coffin and a doll inside, which is a larger scale sample. We were also able to study and reconstruct the complicated structure of a tablet-woven band, as well as identifying individual fibres when examining smaller textile samples with submicron resolution. Even though we observed some limitations in the image quality, we conclude that computed tomography has great potential in the research of archaeological textiles in both 3D and cross-sections and is often easier and more informative than conventional microscopic or other archaeological methodologies.
Effect of Small and Large Energy Surpluses on Strength, Muscle, and Skinfold Thickness in Resistance-Trained Individuals: A Parallel Groups Design
Authors: Helms Eric R. , Spence Alyssa-Joy , Sousa Colby , Kreiger James , Taylor Steve , Oranchuk Dustin J. , Dieter Brad P. , Watkins Casey M. 
Published: November 2023

Abstract
Background
Many perform resistance training (RT) to increase muscle mass and strength. Energy surpluses are advised to support such gains; however, if too large, could cause unnecessary fat gain. We randomized 21 trained lifters performing RT 3 d/wk for eight weeks into maintenance energy (MAIN), moderate (5% [MOD]), and high (15% [HIGH]) energy surplus groups to determine if skinfold thicknesses (ST), squat and bench one-repetition maximum (1-RM), or biceps brachii, triceps brachii, or quadriceps muscle thicknesses (MT) differed by group. COVID-19 reduced our sample, leaving 17 completers. Thus, in addition to Bayesian ANCOVA comparisons, we analyzed changes in body mass (BM) with ST, 1-RM, and MT changes via regression. We reported Bayes factors (BF10) indicating odds ratios of the relative likelihood of hypotheses (e.g., BF10 = 2 indicates the hypothesis is twice as likely as another) and coefficients of determination (R2) for regressions.

Results
ANCOVAs provided no evidence supporting the group model for MT or squat 1-RM. However, moderate (BF10 = 9.9) and strong evidence (BF10 = 14.5) indicated HIGH increased bench 1-RM more than MOD and MAIN, respectively. Further, there was moderate evidence (BF10 = 4.2) HIGH increased ST more than MAIN and weak evidence (BF10 = 2.4) MOD increased ST more than MAIN. Regression provided strong evidence that BM change predicts ST change (BF10 = 14.3, R2 = 0.49) and weak evidence predicting biceps brachii MT change (BF10 = 1.4, R2 = 0.24).

Conclusions
While some group-based differences were found, our larger N regression provides the most generalizable evidence. Therefore, we conclude faster rates of BM gain (and by proxy larger surpluses) primarily increase rates of fat gain rather than augmenting 1-RM or MT. However, biceps brachii, the muscle which received the greatest stimulus in this study, may have been positively impacted by greater BM gain, albeit slightly. Our findings are limited to the confines of this study, where a group of lifters with mixed training experience performed moderate volumes 3 d/wk for 8 weeks. Thus, future work is needed to evaluate the relationship between BM gains, increases in ST and RT adaptations in other contexts.
Access to formal childcare among families of newly arrived migrants from non-EU countries in France
Authors: Eremenko Tatiana , Unterreiner Anne 
Published: November 2023

AbstractLabour force participation of female migrants from non-EU countries, particularly recently arrived, is lower than among other groups and more affected by the presence of children. While care responsibilities are the primary reasons for this situation—immigrant families have a lower use of formal childcare services and less possibilities to receive informal support—the respective role of structural constraints and norms and preferences in this result still raises questions. In addition, families from non-EU countries may encounter greater difficulties in accessing public services, including formal childcare. We explore the determinants of participation in early childhood education (ECEC) among families of recently arrived migrants from outside of the EU in France. We use the Longitudinal Survey on the Integration of First-Time arrivals (Elipa 2) carried out among third country nationals receiving a first residence permit in France in 2018 and focus on their small age children (0–2 years). ECEC enrolment rates are lower than in the general population, and this appears to be primarily linked to these families’ disadvantaged socio-economic position in the destination country. However, families’ distinct socio-economic and cultural resources, as well as their origin, also shape their use of public services. These results contribute to a better understanding of the specific needs and obstacles faced by these families, and identify potential areas for policy actions.
Comparative analysis of the susceptibility of Aedes aegypti and Japanese Aedes albopictus to all dengue virus serotypes
Authors: Kobayashi Daisuke , Kai Izumi , Faizah Astri Nur , Moi Meng Ling , Tajima Shigeru , Takasaki Tomohiko , Sasaki Toshinori , Isawa Haruhiko 
Published: November 2023

Abstract
Background
Dengue fever, caused by the dengue virus (DENV), is the most common viral infection transmitted by Aedes mosquitoes (mainly Ae. aegypti and Ae. albopictus) worldwide. Aedes aegypti is not currently established in Japan, and Ae. albopictus is the primary vector mosquito for DENV in the country, but knowledge of its viral susceptibility is limited. Therefore, we aimed to clarify the status of DENV susceptibility by comparing the infection and dissemination dynamics of Japanese Ae. albopictus to all known DENV serotypes with those of Ae. aegypti.

Methods
After propagation of each DENV serotype in Vero cells, the culture supernatants were mixed with defibrinated rabbit blood and adenosine triphosphate, and the mixture was artificially blood-sucked by two colonies of Ae. albopictus from Japan and one colony of Ae. aegypti from a dengue-endemic country (Vietnam). After 14 days of sucking, the mosquito body was divided into two parts (thorax/abdomen and head/wings/legs) and total RNA was extracted from each sample. DENV RNA was detected in these extracted RNA samples using a quantitative RT-PCR method specific for each DENV serotype, and infection and dissemination rates were analyzed.

Results
The Japanese Ae. albopictus colonies were susceptible to all DENV serotypes. Its infection and dissemination rates were significantly lower than those of Ae. aegypti. However, the number of DENV RNA copies in Ae. albopictus was almost not significantly different from that in Ae. aegypti. Furthermore, Japanese Ae. albopictus differed widely in their susceptibility to each DENV serotype.

Conclusions
In Japanese Ae. albopictus, once DENV overcame the midgut infection barrier, the efficiency of subsequent propagation and dissemination of the virus in the mosquito body was comparable to that of Ae. aegypti. Based on the results of this study and previous dengue outbreak trends, Ae. albopictus is predicted to be highly compatible with DENV-1, suggesting that this serotype poses a high risk for future epidemics in Japan.
Advancing Alzheimer’s care: a novel therapy with lecanemab
Authors: Teli Advait , Dhande Priti 
Published: November 2023

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects the patient’s quality of life. The current regime of drugs only halts the symptoms of the disease, and the underlying pathology remains untouched; thus, there is progressive deterioration due to the intact pathology. Various drugs are being researched to address the complex neuropathology of AD. The FDA has approved lecanemab, which has shown considerable efficacy in reducing Aβ plaque, thereby addressing the pathology. Of the monoclonal antibodies being explored for AD, lecanemab has shown higher selectivity towards Aβ and better efficacy in clinical improvement. The phase III trials have demonstrated clinical improvement of mild AD upon biweekly intravenous administration of 10 mg/kg. This improvement was assessed using the primary and secondary endpoints such as Clinical Dementia Rating-Sum of Boxes (CDR-SOB), Mini-Mental State Examination (MMSE), and Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Apart from the infusion-related reactions with lecanemab, it is also associated with amyloid-related imaging abnormalities (ARIA), which are uniquely seen in monoclonal antibodies for AD as it is also seen in solanezumab and aducanumab. ARIA may be dose-dependent as with lower doses, the incidence was lower, and it is associated with microhemorrhages, hemosiderosis, or edema. Monoclonal antibodies such as aducanumab, agantenerumab have shown questionable efficacy; thus, their clinical use is debatable even though aducanumab has received FDA approval. Although solanezumab met some secondary endpoints, its benefit is similar to the placebo. Currently, efficacy is only proven for monotherapy with lecanemab; therefore, neurologists may need to discontinue adjuvant treatment. Clinical improvement in women and ApoE4 carriers is also questionable; further studies are required to prove its efficacy in these groups. Various studies are being conducted to find the efficacy of drugs targeting the complex pathology of AD, such as the tau targeting E2814, E2025 and E2511 protecting the cholinergic neurons, TREM2 agonists P522R prevent the microglial dysfunction. These drugs are noteworthy as they can be the possible combination of lecanemab. Further studies are required to prove lecanemab’s efficacy in moderate-to-severe AD and its combination with other drugs.
A systematic review and meta-analysis of Surpass flow diverter for the treatment of intracranial aneurysms
Authors: Florez-Perdomo William A. , Janjua Tariq , Moscote-Salazar Luis Rafael , Shrivastava Adesh , Raj Sumit , Agrawal Amit 
Published: November 2023

Abstract
Objective
Systematically review and analyze the published literature on the safety and efficacy of Surpass flow diverter in terms of mortality, functional outcome, complication rate, and aneurysm occlusion rate.

Methods
The literature was searched in PubMed, MEDLINE, Embase, and Scopus using the terms Surpass for the treatment of Intracranial aneurysms, Intracranial aneurysms, Complication with no constraints applied. Two review authors independently conducted the study selection. Two review authors independently extracted study data. Data were pooled using a random effect model, results were abstracted as odds ratios and 95% CI, and heterogeneity was reported as I2.

Results
Five studies were included, which involved retrospectively and prospectively collected data on 464 patients. The use of Surpass flow diverter was associated with a rate of occlusion of 73.4% (95% confidence interval [CI] 62.48–83.077%). Low rate of thromboembolic complication was 6.6% (95% CI 3.0–10.1%), the rate of hemorrhagic complication was 2.9% (95% CI 1.6–4.6%), and low vasospasm rate was 4.38% (95% confidence interval [CI] 1.8–7.7%). The mortality rate was 4.6% (95% CI 1.4–1.4%). An overall of good outcome was 86.6% (95% CI 75.9–94.5%), and poor outcome was 7.8% (95% CI 5.0–11.2%).

Conclusions
Based on the studies available in the literature, Surpass flow diverter offers high aneurysm occlusion rates with adequate safety and low rate of complications.
Using weather data in energy time series forecasting: the benefit of input data transformations
Authors: Neumann Oliver , Turowski Marian , Mikut Ralf , Hagenmeyer Veit , Ludwig Nicole 
Published: November 2023

AbstractRenewable energy systems depend on the weather, and weather information, thus, plays a crucial role in forecasting time series within such renewable energy systems. However, while weather data are commonly used to improve forecast accuracy, it still has to be determined in which input shape this weather data benefits the forecasting models the most. In the present paper, we investigate how transformations for weather data inputs, i. e., station-based and grid-based weather data, influence the accuracy of energy time series forecasts. The selected weather data transformations are based on statistical features, dimensionality reduction, clustering, autoencoders, and interpolation. We evaluate the performance of these weather data transformations when forecasting three energy time series: electrical demand, solar power, and wind power. Additionally, we compare the best-performing weather data transformations for station-based and grid-based weather data. We show that transforming station-based or grid-based weather data improves the forecast accuracy compared to using the raw weather data between 3.7 and 5.2%, depending on the target energy time series, where statistical and dimensionality reduction data transformations are among the best.
Outcome analysis for patients with subarachnoid hemorrhage and vasospasm including endovascular treatment
Authors: Burth Sina , Meis Jan , Kronsteiner Dorothea , Heckhausen Helena , Zweckberger Klaus , Kieser Meinhard , Wick Wolfgang , Ulfert Christian , Möhlenbruch Markus , Ringleb Peter , Schönenberger Silvia 
Published: November 2023

AbstractAs a complication of subarachnoid hemorrhage (SAH), vasospasm substantially contributes to its morbidity and mortality. We aimed at analyzing predictors of outcome for these patients including the role of endovascular treatment (ET). Our database was screened for patients with SAH treated in our Neuro-ICU from 2009 to 2019. Clinical parameters including functional outcome (modified Rankin Scale, mRS of 0–2 or 3–6 at discharge and after a median follow-up of 18 months) and details about ET were gathered on 465 patients, 241 (52%) of whom experienced vasospasm. Descriptive analyses were performed to identify explanatory variables for the dichotomized mRS score. A logistic regression model was fitted on 241 patients with vasospasm including age, Hunt and Hess Score, extraventricular drainage (EVD), forced hypertension, ET and delayed cerebral ischemia (DCI). The model found a Hunt and Hess Score of 5 (OR = 0.043, p = 0.008), requirement of EVD (OR = 0.161, p < 0.001), forced hypertension (OR = 0.242, p = 0.001), ET (OR = 0.431, p = 0.043) and DCI (OR = 0.229, p < 0.001) to be negative predictors of outcome while age was not. Use of intraarterial nimodipine alone (OR = 0.778, p = 0.705) or including balloon angioplasty (OR = 0.894, p = 0.902) and number of ETs per patient (OR = 0.757, p = 0.416) were not significant in a separate model with otherwise identical variables. While DCI is clearly associated with poor outcome, the influence of ET on outcome remains inconclusive. Limited by their retrospective nature and an indication bias, these data encourage a randomized assessment of ET.
Graphical abstract
Effect of GLITEROS specific-diabetes enteral formula modification based on tempe flour, jicama flour and sunflower seed flour on score pancreatic damage, number and diameter of the islets of langerhans of hyperglycemic rats pancreatic cells with streptozotocin induction
Authors: Wijayanti Lilis , Muniroh Muflihatul , Al-Baarri Ahmad Ni’matullah , Fitranti Deny Yudi , Mahati Endang , Afifah Diana Nur 
Published: November 2023

AbstractTempeh, yam, and sunflower's flour have been known to have antidiabetic effects, but their combined effect on the histopathology of hyperglycemic rat pancreatic cells in an enteral formula has not been proven. This study aimed to analyze the effect of GLITEROS specific-diabetes enteral formula modification based on tempeh flour, yam flour, and sunflower seed flour on the score pancreatic damage, number and diameter of the islets of langerhans of hyperglycemic rats with streptozotocin induction. The intervention was administered via an oral probe for 28 days to 30 Wistar rats, with each group consisting of 6 rats. The formula was given at a dose of 3.97 g/200 g/day (P1) and 8.75 g/200gr/day (P2) compared to standard control (K), positive control (K +), and negative control (K-). Histopathological features of the pancreas were analyzed using the hematoxylin–eosin staining method. Data were analyzed using paied t-test/Wilcoxon and ANOVA/Kruskal Wallis. The results showed a significant repair of pancreatic cell damage in the treatment group (P1 and P2) after the intervention (p < 0.05), but there was no difference in the number and diameter of the islets of Langerhans (p > 0.05). Overall, our findings suggest that the modified GLITEROS specific-diabetes enteral formula made from tempeh, yam, and sunflower seeds flour on the histopathological picture of hyperglycemia-induced rat pancreas, especially in the repair of damage to pancreatic Langerhans cells.
Graphical Abstract