bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioclimatic predictors of forest structure, composition and phenology in the Paraguayan Dry Chaco
Authors: Ruiz-Díaz Susana , Pérez de Molas Lidia Florencia , Benítez-León Enrique , Almeyda Zambrano Angélica María , Johnson Daniel J. , Bohlman Stephanie , Broadbent Eben North 
Published: January 2024

Abstract
One of the largest remnants of tropical dry forest is the South American Gran Chaco. A quarter of this biome is in Paraguay, but there have been few studies in the Paraguayan Chaco. The Gran Chaco flora is diverse in structure, function, composition and phenology. Fundamental ecological questions remain in this biome, such as what bioclimatic factors shape the Chaco’s composition, structure and phenology. In this study, we integrated forest inventories from permanent plots with monthly high-resolution NDVI from PlanetScope and historical climate data from WorldClim to identify bioclimatic predictors of forest structure, composition and phenology. We found that bioclimatic variables related to precipitation were correlated with stem density and Pielou evenness index, while temperature-related variables correlated with basal area. The best predictor of forest phenology (NDVI variation) was precipitation lagged by 1 month followed by temperature lagged by 2 months. In the period with most water stress, the phenological response correlates with diversity, height and basal area, showing links with dominance and tree size. Our results indicate that even if the ecology and function of Dry Chaco Forest is characterised by water limitation, temperature has a moderating effect by limiting growth and influencing leaf flush and deciduousness.
Transatlanticism: A fading paradigm?
Authors: Scott-Smith Giles 
Published: January 2024

AbstractIn 2018, the first full year of the Trump presidency, it became abundantly clear that the transatlantic relationship had entered a period of intense discord, causing a series of pessimistic reports and commentary in the mainstream Anglo-American media. With this as the starting point, the article re-examines the study of the ‘transatlantic’ as a region. It engages with thinking of time (periodisation), space (scale), and discipline (methodology) in order to question standard assumptions and open up new avenues for research, identity-formation, and emancipatory commitment.
Stress and emotion recognition predict the relationship between a history of maltreatment and sensitive parenting behaviors: A moderated-moderation
Authors: Bérubé Annie , Pearson Jessica , Blais Caroline , Forget Hélène 
Published: January 2024

AbstractOur study proposes to examine how stress and emotion recognition interact with a history of maltreatment to influence sensitive parenting behaviors. A sample of 58 mothers and their children aged between 2 and 5 years old were recruited. Parents’ history of maltreatment was measured using the Child Trauma Questionnaire. An emotion recognition task was performed. Mothers identified the dominant emotion in morphed facial emotion expressions in children. Mothers and children interacted for 15 minutes. Salivary cortisol levels of mothers were collected before and after the interaction. Maternal sensitive behaviors were coded during the interaction using the Coding Interactive Behavior scheme. Results indicate that the severity of childhood maltreatment is related to less sensitive behaviors for mothers with average to good abilities in emotion recognition and lower to average increases in cortisol levels following an interaction with their children. For mothers with higher cortisol levels, there is no association between a history of maltreatment and sensitive behaviors, indicating that higher stress reactivity could act as a protective factor. Our study highlights the complex interaction between individual characteristics and environmental factors when it comes to parenting. These results argue for targeted interventions that address personal trauma.
Exploring genetic diversity of Centella asiatica (L.) Urb. across six Korean island regions: implications for conservation and utilization
Authors: Lee Shin Ae , Seo Hyemin , Han Seahee , Jeong Jun Seong , Jung Tae Won , Lee Kyung Jun 
Published: January 2024

AbstractDespite the increasing demand for diverse Centella asiatica (L.) Urb. species in Korea, studies on related topics are limited, with the majority of studies focusing on functional evaluations, rather than genetic diversity. Therefore, in this study, we explored the genetic diversity of C. asiatica, a valuable medicinal plant collected from six island regions in Korea, using genotyping-by-sequencing analysis. Specifically, we aimed to understand plant genetic variations, population structure and the potential for conservation and genetic improvement. The results indicated relatively high genetic diversity among the samples collected from the six island regions but low genetic differentiation among their populations. Two distinct genetic clusters were identified; however, even within these clusters, genetic differentiation was minimal. The lack of significant isolation-by-distance patterns and evidence of potential clonal spread suggested that some individuals that adapted to colder Korean conditions achieved dominance. This study highlights the importance of assessing the genetic diversity of native C. asiatica in Korea and explores the possibility of conducting follow-up studies to understand the phytochemical content and bioactivity variations among the individuals. This information can aid in the selection of superior resources and effective utilization of plant genetic resources for cultivar development and other applications.
Controlling Factors on REY Enrichments in Basins From the Pacific Ocean: Early Diagenesis and Local Constraints
Authors: Liao Jianlin , Chen Jieyun , Sun Xiaoming , Deng Yinan , Wang Yanjingyu , Wang Dajin , Hong Gang , Klose Lukas , Koschinsky Andrea 
Published: January 2024

AbstractIncreasing interest in high‐tech metals (e.g., rare earth elements and yttrium, REY) has triggered extensive research on the enrichment of these metals in pelagic sediments. In the sediments collected worldwide, Ca‐phosphate and Fe‐Mn (oxyhydr)oxides are targeted as the two most important REY carriers based on multiple geochemical and mineralogical analyses. However, the formation of the REY‐rich stratum remains enigmatic as the influences of diagenesis and the local restrictions of different oceanic basins are complex, which require further investigation. In our study, we analyzed four sediment cores from the Western, Central North, and Eastern South Pacific (WP, CNP, and ESP), which are three of the most promising REY‐rich regions in global oceans. Sequential leaching quantifies the dominance of Ca‐phosphate by controlling ∼73.9%–93.3% of ΣREY and the secondary role of Fe‐Mn (oxyhydr)oxides by holding up to ∼97.8% of Ce and ∼4.82%–13.9% of ΣREY. The shallowly and deeply buried sediments show similar features regarding the REY proportions hosted by different phases, which indicates that the REY accumulation by Ca‐phosphate might majorly occur on the seawater‐sediment interface. The geochemistry of the studied sediment cores reveals that (a) REY enrichment in ESP is affected by hydrothermal Fe‐Mn (oxyhydr)oxides which can promote adsorptions of P and REY. (b) The Fe and Mn contents in WP sediments show an inverse relationship against REY enrichment which might be explained by the dust input from Central Asia. (c) The slow sedimentation rate of CNP enables the extraordinary REY‐uptake by Ca‐phosphate, but the low flux of phosphorus constrains the formation of high‐grade REY deposits.
Precipitation Scaling in Extreme Rainfall Events and the Implications for Future Indian Monsoon: Analysis of High‐Resolution Global Climate Model Simulations
Authors: Varghese Stella Jes , Surendran Sajani , Rajendran Kavirajan , Ghosh Subimal , Kitoh Akio , Ashok Karumuri 
Published: January 2024

AbstractThe increase in water holding capacity of the atmosphere with temperature, given by the Clausius‐Clapeyron (CC) relationship, describes the changes in extreme rainfall intensities at warmer atmospheric states. We study the characteristics of extreme rainfall events (EREs) during the Indian summer monsoon season with respect to thermodynamic changes and precipitation‐scaling over the Indian subcontinent and its homogeneous rainfall zones. We utilize outputs from a present‐day climate simulation and a time‐slice future climate change projection experiments of a high‐resolution global climate model. Large changes are seen for very EREs (vEREs) which suggests their sensitivity to warmer temperatures. In future, the altered radiative forcing will heat up the upper atmosphere, stabilize it and offset the effect of increasing humidity on precipitation intensity. Our analysis also suggests that more convective clouds and the interplay of increased moisture content and circulation will result in future changes in EREs.
Understanding Rapid Intensification of Typhoon Mujigae in 2015: Insights From Kinetic and Potential Energy Budgets
Authors: Zhang Chi , Li Xiaofan , Zhai Guoqing , Shen Xinyong 
Published: January 2024

AbstractThis study investigated the kinetic and potential energy budgets during the slow (SI) and rapid intensification (RI) periods of Typhoon Mujigae, which occurred in October 2015, by conducting a Weather Research and Forecasting model simulation. We found that the kinetic energy conversion between asymmetric and symmetric rotational circulations in the lower troposphere plays a pivotal role in initiating the difference in the tendency of symmetric rotational kinetic energy between the RI and SI via the horizontal advection process of asymmetric circulations. Southerly and easterly environmental flows transported asymmetric anticyclonic flows in SI and cyclonic flows in RI to the radius of maximum wind, respectively, where asymmetric rotational circulation was developed by vertical shear of environmental flow. Such transports initiate the growth of symmetric cyclonic rotational circulation from SI to RI. The kinetic energy conversion of symmetric divergent circulations supported by symmetric potential energy accelerates the growth of symmetric rotational kinetic energy from SI to RI. These findings can shed light on the fundamental dynamics of the RI of tropical cyclones.
WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis
Authors: An Xueying , Wang Rongliang , Lv Zhongyang , Wu Wenshu , Sun Ziying , Wu Rui , Yan Wenjin , Jiang Qing , Xu Xingquan 
Published: January 2024

AbstractOsteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes. Mechanistically, the m6A modification and relative downstream targets in osteoarthritic cartilage were assessed by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing, which indicated that the expression of frizzled-related protein (FRZB), a secreted Wnt antagonist, was abnormally decreased and accompanied by high m6A modification in osteoarthritic cartilage. In vitro dysregulated WTAP had positive effects on β-catenin expression by targeting FRZB, which finally contributed to the cartilage injury phenotype in chondrocytes. Intra-articular injection of adeno-associated virus-WTAP alleviated OA progression in a mouse model, while this protective effect could be reversed by the application of a Wnt/β-catenin activator. In summary, this study revealed that WTAP-dependent RNA m6A modification contributed to Wnt/β-catenin pathway activation and OA progression through post-transcriptional regulation of FRZB mRNA, thus providing a potentially effective therapeutic strategy for OA treatment.
4-1BB immunotherapy: advances and hurdles
Authors: Singh Rohit , Kim Young-Ho , Lee Sang-Jin , Eom Hyeon-Seok , Choi Beom K. 
Published: January 2024

AbstractSince its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated immune functions. Numerous studies have demonstrated the involvement of 4-1BB in infection and tumor immunity. However, the clinical development of 4-1BB agonist antibodies has been impeded by the occurrence of strong adverse events, notably hepatotoxicity, even though these antibodies have exhibited tremendous promise in in vivo tumor models. Efforts are currently underway to develop a new generation of agonist antibodies and recombinant proteins with modified effector functions that can harness the potent T-cell modulation properties of 4-1BB while mitigating adverse effects. In this review, we briefly examine the role of 4-1BB in T-cell biology, explore its clinical applications, and discuss future prospects in the field of 4-1BB agonist immunotherapy.
GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents
Authors: Klein Adam K. , Austin Eric W. , Cunningham Michael J. , Dvorak Dino , Gatti Silvia , Hulls Sarah K. , Kiss Laszlo , Kruegel Andrew C. , Marek Gerard J. , Papp Mariusz , Sporn Jonathan , Hughes Zoë A. 
Published: January 2024

AbstractThe NMDA receptor (NMDAR) antagonist ketamine has shown great potential as a rapid-acting antidepressant; however, its use is limited by poor oral bioavailability and a side effect profile that necessitates in-clinic dosing. GM-1020 is a novel NMDAR antagonist that was developed to address these limitations of ketamine as a treatment for depression. Here, we present the preclinical characterization of GM-1020 alongside ketamine, for comparison. In vitro, we profiled GM-1020 for binding to NMDAR and functional inhibition using patch-clamp electrophysiology. In vivo, GM-1020 was assessed for antidepressant-like efficacy using the Forced Swim Test (FST) and Chronic Mild Stress (CMS), while motor side effects were assessed in spontaneous locomotor activity and on the rotarod. The pharmacokinetic properties of GM-1020 were profiled across multiple preclinical species. Electroencephalography (EEG) was performed to determine indirect target engagement and provide a potentially translational biomarker. These results demonstrate that GM-1020 is an orally bioavailable NMDAR antagonist with antidepressant-like efficacy at exposures that do not produce unwanted motor effects.
Parental and child genetic burden of glycaemic dysregulation and early-life cognitive development: an Asian and European prospective cohort study
Authors: Huang Jian , Kee Michelle Z. L. , Law Evelyn C. , Sum Ka Kei , Silveira Patricia Pelufo , Godfrey Keith M. , Daniel Lourdes Mary , Tan Kok Hian , Chong Yap Seng , Chan Shiao-Yng , Eriksson Johan G. , Meaney Michael J. , Huang Jonathan Yinhao 
Published: January 2024

AbstractInsulin resistance and glucose metabolism have been associated with neurodevelopmental disorders. However, in the metabolically more susceptible Asian populations, it is not clear whether the genetic burden of glycaemic dysregulation influences early-life neurodevelopment. In a multi-ethnic Asian prospective cohort study in Singapore (Growing Up in Singapore Towards healthy Outcomes (GUSTO)), we constructed child and parental polygenic risk scores (PRS) for glycaemic dysregulation based on the largest genome-wide association studies of type 2 diabetes and fasting glucose among Asians. We found that child PRS for HOMA-IR was associated with a lower perceptual reasoning score at ~7 years (β = −0. 141, p-value = 0.024, 95% CI −0. 264 to −0. 018) and a lower WIAT-III mean score at ~9 years (β = −0.222, p-value = 0.001, 95% CI −0.357 to −0.087). This association were consistent in direction among boys and girls. These inverse associations were not influenced by parental PRS and were likely mediated via insulin resistance rather than mediators such as birth weight and childhood body mass index. Higher paternal PRS for HOMA-IR was suggestively associated with lower child perceptual reasoning at ~7 years (β = −0.172, p-value = 0.002, 95% CI −0.280 to −0.064). Replication analysis in a European cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, showed that higher child PRS for fasting glucose was associated with lower verbal IQ score while higher maternal PRS for insulin resistance was associated with lower performance IQ score in their children at ~8.5 years. In summary, our findings suggest that higher child PRS for HOMA-IR was associated with lower cognitive scores in both Asian and European replication cohorts. Differential findings between cohorts may be attributed to genetic and environmental factors. Further investigation of the functions of the genetic structure and ancestry-specific PRS and a more comprehensive investigation of behavioural mediators may help to understand these findings better.
Resistance to BRAF inhibition explored through single circulating tumour cell molecular profiling in BRAF-mutant non-small-cell lung cancer
Authors: Mezquita Laura , Oulhen Marianne , Aberlenc Agathe , Deloger Marc , Aldea Mihaela , Honore Aurélie , Lecluse Yann , Howarth Karen , Friboulet Luc , Besse Benjamin , Planchard David , Farace Françoise 
Published: January 2024

Abstract
Background
Resistance mechanisms to combination therapy with dabrafenib plus trametinib remain poorly understood in patients with BRAFV600E-mutant advanced non-small-cell lung cancer (NSCLC). We examined resistance to BRAF inhibition by single CTC sequencing in BRAFV600E-mutant NSCLC.

Methods
CTCs and cfDNA were examined in seven BRAFV600E-mutant NSCLC patients at failure to treatment. Matched tumour tissue was available for four patients. Single CTCs were isolated by fluorescence-activated cell sorting following enrichment and immunofluorescence (Hoechst 33342/CD45/pan-cytokeratins) and sequenced for mutation and copy number-alteration (CNA) analyses.

Results
BRAFV600E was found in 4/4 tumour biopsies and 5/7 cfDNA samples. CTC mutations were mostly found in MAPK-independent pathways and only 1/26 CTCs were BRAFV600E mutated. CTC profiles encompassed the majority of matched tumour biopsy CNAs but 72.5% to 84.5% of CTC CNAs were exclusive to CTCs. Extensive diversity, involving MAPK, MAPK-related, cell cycle, DNA repair and immune response pathways, was observed in CTCs and missed by analyses on tumour biopsies and cfDNA. Driver alterations in clinically relevant genes were recurrent in CTCs.

Conclusions
Resistance was not driven by BRAFV600E-mutant CTCs. Extensive tumour genomic heterogeneity was found in CTCs compared to tumour biopsies and cfDNA at failure to BRAF inhibition, in BRAFV600E-mutant NSCLC, including relevant alterations that may represent potential treatment opportunities.
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Authors: Shi Tengfei , Guo Dianhao , Zheng Yaoqiang , Wang Wenbin , Bi Jinfang , He Anshun , Fan Sibo , Su Guangsong , Zhao Xueyuan , Zhao Zhenhao , Song Yingjie , Sun Shupeng , Li Peng , Zhao Zhongfang , Shi Jiandang , Lu Wange , Zhang Lei 
Published: January 2024

AbstractGlioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modulate TMZ sensitivity via regulation of SORBS2 and DDR1 genes by super-enhancer RNA LINC02454. We report that LINC02454 activity increases glioma cell TMZ sensitivity by maintaining long-range chromatin interactions between SORBS2 and the LINC02454 enhancer. By contrast, LINC02454 activity also decreased glioma cell TMZ sensitivity by promoting DDR1 expression. Our study suggests a bivalent function for super-enhancer RNA LINC02454 in regulating glioma cell sensitivity to TMZ.
A cross-scale framework for evaluating flexibility values of battery and fuel cell electric vehicles
Authors: Liu Ruixue , He Guannan , Wang Xizhe , Mallapragada Dharik , Zhao Hongbo , Shao-Horn Yang , Jiang Benben 
Published: January 2024

AbstractFlexibility has become increasingly important considering the intermittency of variable renewable energy in low-carbon energy systems. Electrified transportation exhibits great potential to provide flexibility. This article analyzed and compared the flexibility values of battery electric vehicles and fuel cell electric vehicles for planning and operating interdependent electricity and hydrogen supply chains while considering battery degradation costs. A cross-scale framework involving both macro-level and micro-level models was proposed to compute the profits of flexible EV refueling/charging with battery degradation considered. Here we show that the flexibility reduction after considering battery degradation is quantified by at least 4.7% of the minimum system cost and enlarged under fast charging and low-temperature scenarios. Our findings imply that energy policies and relevant management technologies are crucial to shaping the comparative flexibility advantage of the two transportation electrification pathways. The proposed cross-scale methodology has broad implications for the assessment of emerging energy technologies with complex dynamics.
VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity
Authors: Bapat Ojasee , Purimetla Tejas , Kruessel Sarah , Shah Monil , Fan Ruolin , Thum Christina , Rupprecht Fiona , Langer Julian D. , Rangaraju Vidhya 
Published: January 2024

AbstractSynapses are pivotal sites of plasticity and memory formation. Consequently, synapses are energy consumption hotspots susceptible to dysfunction when their energy supplies are perturbed. Mitochondria are stabilized near synapses via the cytoskeleton and provide the local energy required for synaptic plasticity. However, the mechanisms that tether and stabilize mitochondria to support synaptic plasticity are unknown. We identified proteins exclusively tethering mitochondria to actin near postsynaptic spines. We find that VAP, the vesicle-associated membrane protein-associated protein implicated in amyotrophic lateral sclerosis, stabilizes mitochondria via actin near the spines. To test if the VAP-dependent stable mitochondrial compartments can locally support synaptic plasticity, we used two-photon glutamate uncaging for spine plasticity induction and investigated the induced and adjacent uninduced spines. We find VAP functions as a spatial stabilizer of mitochondrial compartments for up to ~60 min and as a spatial ruler determining the ~30 μm dendritic segment supported during synaptic plasticity.