bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pembuatan Konten Tiktok bagi Guru PPKn sebagai Sumber Belajar Peserta Didik
Authors: Alfiandra Alfiandra , Susanti Emi , Manangsang Anang , Adila Rezki , Dameliza Okta , Nauval Sidrotun 
Published: November 2023

Pembelajaran saat ini tidak lepas dari pengaruh teknologi yang membawa pendidikan dapat dipelajari dimanapun tidak hanya terpaku pada buku mata pelajaran. Tujuan dari pengabdian ini adalah memberikan pelatihan dan pendampingan kepada guru PPKn di SMA Srijaya Negara dalamÂ memanfaatkan TikTok sebagai sumber belajar. Metode dan bentuk kegiatan pengabdian kepada masyarakat ini adalah pelatihan, dengan teknik sosialisasi secara luring yang divariasikan dengan praktik langsung dan tanya jawab serta didemonstrasikan berupa produk video materi PPKn. Sasaran pengabdian ini yaitu dua orang guru PPKn SMA Srijaya Negara. Kegiatan ini memperoleh hasil bahwa guru yang sebelumnya belum bisa memanfaatkan TikTok sebagai sumber belajar, sudah mampu membuat konten yang menarik di TikTok. Dibuktikan dengan selama kurang lebih 3 minggu, guru telah membuat konten PPKn yang kreatif dan disukai oleh peserta didik. Konten yang dibuat oleh guru telah di tonton lebih dari 500 viewers dan telah dikomentari oleh peserta didik. Kegiatan pelatihan dan pendampingan yang dilaksanakan telah memberikan dampak cukup signifikan bagi guru mengenai pemanfaatan TikTok sebagai sumber belajar.
Corporate Governance Mechanisms and Sustainability Reporting Practices of Listed Non-Financial Firms in Nigeria
Authors: Razaq Abubakar Garba , Alhassan Abdulkarim , Omole Paul Martins 
Published: November 2023

The Board plays a pivotal role in the administration of corporate affairs. An effective Board oversight function basically consists of proper mechanisms for providing entrepreneurial and strategic leadership as well as promoting ethical values that allow stakeholders to exercise their rights to protect their investments’ sustainability. This study examined the effect of corporate governance mechanisms on sustainability reporting of listed non-financial firms in Nigeria. The study measured corporate governance attributes with board size, board independence, board gender diversity, board financial expertise and sustainability reporting was measured by sustainability disclosures metrics in line with Global Reporting Initiative (GRI) standards. The study adopted correlation research design relying on secondary data obtained from annual reports of the population, which comprised of 116 non-financial firms listed on Nigeria Exchange Group (NGX) as at 31st December 2020 with a sample size of 51 firms, covering the period of 2011 – 2020. The study employed multiple regression panel model to analyze the data with the aid of E-view 10 statistical tool. According to the results of random effect regression, board size and board members’ financial expertise have positive and significant effect on sustainability reporting. Based on the findings, the study concluded that corporate governance attributes have the capacity to effectively enhance the sustainability reporting of firms. Thus, the study recommended among others that regulators in financial reporting should mandate firms to have a sizeable board with members having financial expertise as a measure of enhancing sustainability reporting in Nigeria.
The Efficacy of Preoperative Tamsulosin on Ureteroscopy Access in Pediatrics: A Systematic Review and Meta-Analysis
Authors: Singgih Nicholas Andrian , Oktaviani Jacinda Risha , Pranowo Sampurno Secodiningrat Raden Honggo , Adipurnama William , Manuputty Egi Edward , Tandarto Kevin 
Published: November 2023

Objective: The incidence of urolithiasis in pediatrics increases to 4-10% annually. One of the methods for treating urolithiasis is ureteroscopy (URS). The small anatomy in pediatrics often makes the initial URS unsuccessful. Alpha blockers, a drug that can relax the ureteral muscles, is a therapy that can be considered before URS is carried out. The objective of this study is to evaluate the efficacy of preoperative tamsulosin for URS access in pediatrics. Materials and Methods: We conducted a search using four databases, including PubMed, EBSCO, Cochrane Library, and ProQuest. This study includes randomized controlled trials (RCTs), retrospective and prospective studies, which compared the efficacy of preoperative alpha blockers and placebo or non-placebo controls in pediatrics undergoing ureteroscopy. The outcome of interest was the success rate of URS access and the duration of surgery. Results: A total of 120 studies were identified from a database search. There were 3 studies included in this review involving 235 patients. The meta-analysis was conducted using a random-effects model. The results of the meta-analysis showed that alpha blockers provided a successful rate of ureteroscopy access in pediatric patients (Odds ratio (OR) 2.73; 95% confidence interval (CI) 1.52 up to 4.91; p=0.0008). Duration of surgery did not show significant results (Mean difference (MD) 3.46; 95% CI -3.59 up to 10.50; p=0.34).
Sosialiasi Keselamatan Berlalu Lintas Di Sekolah Dasar Islam Terpadu Insantama Kota Ternate
Authors: Ahadian Edward Rizky , Shandy Sary , Darwis Muhammad , Winata Arya , Irnawaty Irnawaty 
Published: November 2023

Kecelakaan sering kali disebabkan oleh budaya berlalu lintas, kompetensi pengemudi, pemahaman regulasi, serta kondisi sarana dan prasarana transportasi darat selain faktor cuaca ekstrem. Jika semua taat, maka angka kecelakaan di jalan raya bisa ditekan. Salah satu upaya untuk mewujudkan hal tersebut adalah melalui sosialisasi keselamatan berlalu lintas pada anak sekolah. Target yang ingin dicapai dalam kegiatan sosialisasi keselamatan berlalu lintas adalah anak-anak dapat memahami dan mengerti fungsi dari rambu-rambu lalu lintas. Penyampaian dilakukan secara lisan dan dalam bentuk gambar atau video dari rambu-rambu lalu lintas dan video animasi tentang berlalu lintas dengan baik dan benar. Dengan diadakannya Sosialiasi Keselamatan Berlalu Lintas Di Sekolah Dasar Islam Terpadu Insantama Kota Ternate ini, mampu memberikan kesadaran bagi siswa siswi mengenai pentingnya mengetahui berbagai macam rambu lalu lintas agar kelak ketika mereka telah mencapai umur untuk berkendara, maka mereka bisa mematuhi rambu-rambu yang ada di jalan tersebut.Kata Kunci: Keselamatan, Berlalu Lintas, Usia, Dini.
Pengaruh Terapi Qur'anic Healing Terhadap Penurunan Tekanan Darah Pada Lanjut Usia Penderita Hipertensi
Authors: Nurhakim Aghim Ilham , Dewi Inggriane Puspita , Rohmah Nur 
Published: November 2023

Penelitian ini dilatarbelakangi oleh tingginya angka kejadian hipertensi di Kota Bandung sebesar 27.611 jiwa. Penatalaksanaan hipertensi secara non farmakologi diperlukan untuk meningkatkan kualitas hidup penderita hipertensi. Terapi non-farmakologis yang dapat dilakukan yaitu terapi quranic healing yaitu terapi psikoreligius dengan cara membaca Al-Quran. Penelitan ini dilakukan untuk mengetahui pengaruh dari terapi qurâ€™anic healing terhadap penurunan tekanan darah pada lanjut usia penderita hipertensi di Panti Werdha. Populasi dalam penelitian ini adalah lanjut usia yang menderita hipertensi berjumlah 18 orang. Desain penelitian ini menggunakan pre-eksperimental one group pre-test and post-test dengan teknik total sampling. Terdapat 18 responden yang menjalani terapi membaca 1 kali surat Ar-Rahman ayat 1-30 pada hari pertama, dan pada hari kedua sebanyak 3 kali membaca surat yang sama. Hasil penelitian terdapat pengaruh yang signifikan terapi qurâ€™anic healing terhadap penurunan tekanan darah pada lanjut usia penderita hipertensi di Panti Werdha, dengan p value 0.001 dan terdapat perbedaan rerata systole dan diastole yang signifikan dengan p value 0.001 , pada intervensi 1 kali membaca surat Ar-Rahman ayat 1-30 dibandingkan dengan 3 kali membaca surat yang sama secara berturut-turut. Berdasarkan hasil penelitian ini, qurâ€™anic healing dapat menjadi alternatif intervensi non farmakologis pada lanjut usia dengan hipertensi.
Ecological momentary assessments of real-world speech listening are associated with heart rate and acoustic condition
Authors: Andersson Klaudia Edinger , Neher Tobias , Christensen Jeppe Høy 
Published: November 2023

Background and aimEcological momentary assessment (EMA) can provide insights into the real-world auditory ecology of hearing aid (HA) users. To better understand what factors, influence the real-world listening experiences of this population, more detailed models of human auditory ecology and behavior are needed. Laboratory studies suggest that physiological measures are sensitive to different listening experiences, as changes in physiological signals (e.g., pupil dilation) have been associated with effortful listening. In addition, real-world heart rate (HR) has been shown to be sensitive to acoustic influences (e.g., sound pressure level, SPL, and signal-to-noise ratio, SNR). Here, we hypothesized that including physiological and acoustic data in models predicting EMA ratings can provide additional insights into real-world listening outcome. To test this, we collected and analyzed longitudinal data from individuals with normal hearing.MethodFifteen normal-hearing adults completed smartphone-based EMAs regarding their listening experiences during a 2-week period. When completing the EMAs, they had to indicate their current listening intent. The participants received a single HA each that they fastened to their collars. The HAs were used to collect continuous SPL and SNR data in the participants' daily environments. Wristbands worn by the participants were used to collect continuous HR data.ResultsLinear mixed-effects models with SPL, SNR, and HR as fixed effects and participant as random intercept showed that higher SPL and lower SNR were associated with lower (poorer) EMA ratings. Including listening intent in the analyses revealed increased HR in “speech communication” and “focused listening” situations to be associated with better EMA ratings relative to situations without any specific listening intent.ConclusionsOur findings indicate that including in-situ HR and acoustic measurements can improve the prediction of real-world listening experiences. Further, they suggest that listening intent significantly impacts self-reported listening experiences and their association with physiological responses. Specifically, better listening experiences in speech communication situations are associated with higher HR.
Risk factors and the value of microbiological examinations of COVID-19 associated pulmonary aspergillosis in critically ill patients in intensive care unit: the appropriate microbiological examinations are crucial for the timely diagnosis of CAPA
Authors: Zhou Xiaoyi , Wu Xiaojing , Chen Ziying , Cui Xiaoyang , Cai Ying , Liu Youfang , Weng Bingbing , Zhan Qingyuan , Huang Linna 
Published: November 2023

IntroductionDuring the Omicron pandemic in China, a significant proportion of patients with Coronavirus Disease 2019 (COVID-19) associated pulmonary aspergillosis (CAPA) necessitated admission to intensive care unit (ICU) and experienced a high mortality. To explore the clinical risk factors and the application/indication of microbiological examinations of CAPA in ICU for timely diagnosis are very important.MethodsThis prospective study included patients with COVID-19 admitted to ICU between December 1, 2022, and February 28, 2023. The clinical data of influenza-associated pulmonary aspergillosis (IAPA) patients from the past five consecutive influenza seasons (November 1, 2017, to March 31, 2022) were collected for comparison. The types of specimens and methods used for microbiological examinations were also recorded to explore the efficacy in early diagnosis.ResultsAmong 123 COVID-19 patients, 36 (29.3%) were diagnosed with probable CAPA. CAPA patients were more immunosuppressed, in more serious condition, required more advanced respiratory support and had more other organ comorbidities. Solid organ transplantation, APACHEII score ≥20 points, 5 points ≤SOFA score &lt;10 points were independent risk factors for CAPA. Qualified lower respiratory tract specimens were obtained from all patients, and 84/123 (68.3%) patients underwent bronchoscopy to obtain bronchoalveolar lavage fluid (BALF) specimens. All patients’ lower respiratory tract specimens underwent fungal smear and culture; 79/123 (64.2%) and 69/123 (56.1%) patients underwent BALF galactomannan (GM) and serum GM detection, respectively; metagenomic next-generation sequencing (mNGS) of the BALF was performed in 62/123 (50.4%) patients. BALF GM had the highest diagnostic sensitivity (84.9%), the area under the curve of the mNGS were the highest (0.812).ConclusionThe incidence of CAPA was extremely high in patients admitted to the ICU. CAPA diagnosis mainly depends on microbiological evidence owing to non-specific clinical manifestations, routine laboratory examinations, and CT findings. The bronchoscopy should be performed and the BALF should be obtained as soon as possible. BALF GM are the most suitable microbiological examinations for the diagnosis of CAPA. Due to the timely and accuracy result of mNGS, it could assist in early diagnosis and might be an option in critically ill CAPA patients.
Transcriptomics and interactomics during the primary infection of an SfNPV baculovirus on Spodoptera frugiperda larvae
Authors: Rangel-Núñez Jonatan Carmen , Ibarra Jorge E. , Del Rincón-Castro Ma. Cristina 
Published: November 2023

The fall armyworm (FAW), Spodoptera frugiperda, has been the most devastating pest of corn as well as of other crops in America, and more recently in Africa and Asia. The development of resistance to chemical insecticides led the search for environmentally friendly biological alternatives such as baculoviruses. This study focuses on the primary infection of the baculovirus SfNPV-Ar in the FAW’s midgut epithelium, by analyzing the differential expression of transcripts in excised midguts at 6, 12, and 24 h post-infection (hpi), and predicted their interactions. Interaction of viral factors with the infected midgut tissue could alters various cellular processes, such as the apoptotic system due to the up-regulation observed of FABP at 6 hpi and of HSP90 at 24 hpi, along with the down-regulated PRX at 6 hpi and FABP transcripts between 12 and 24 hpi. Changes in transcript regulation could affect the cellular architecture of infected cells due to up-regulation of ARP 2/3 at 6 and 12 hpi, followed by down-regulation at 24 hpi. In relation to protein folding proteins, HSP90 was up-regulated at 24 hpi and PDI was down-regulated between 6 and 12 hpi. With respect to metabolism and cellular transport, AcilBP and ATPS0 were up regulated at 6 hpi and 12 hpi, respectively. In reference to transcription and translation up-regulation of RPL11 at 6 hpi and of FPN32 and RPL19 at 24 hpi was detected, as well as the down-regulation of RPL19 at 6 hpi, of PDI and RPL7 at 12 hpi, and of FABP at 24 hpi. In conclusion, gene regulation induced by viral infection could be related to the cytoskeleton and cellular metabolism as well as to oxidative stress, apoptosis, protein folding, translation, and ribosomal structure. The results presented in this work are an approach to understanding how the virus takes control of the general metabolism of the insect host during the primary infection period.
Short-term echocardiographic follow-up after hospitalization for COVID-19: a focus on early post-acute changes
Authors: Honchar Oleksii , Ashcheulova Tetiana 
Published: November 2023

BackgroundImpaired physical functional status is one of the typical long-term sequelae of COVID-19 infection that significantly affects the quality of life and work capacity. Minor changes in cardiac structure and function that are unable to cause the manifestation of overt heart failure may remain undetected in COVID-19 convalescents, at the same time potentially contributing to the persistence of symptoms and development of long COVID syndrome.PurposeTo study the typical features and short-term dynamics of cardiac remodeling and possible signs of cardiac dysfunction following hospitalization for COVID-19.MethodsThis is a combined cross-sectional and longitudinal cohort study in which 176 hospitalized patients (93 female and 83 male, mean age 53.4 ± 13.6 years) with COVID-19 infection underwent comprehensive transthoracic echocardiography pre-discharge (22.6 ± 7.1 days from the onset of symptoms) with repeated evaluation after 1 month. The control group included 88 age-, sex-, height- and weight-matched healthy individuals, with a subset of those (n = 53) matched to the subset of non-hypertensive study participants (n = 106).ResultsConcentric left ventricular geometry was revealed in 59% of participants, including 43% of non-hypertensive subjects; predominantly Grade I diastolic dysfunction was found in 35 and 25% of patients, respectively. Other findings were naturally following from described phenotype of the left venticle and included a mild increase in the absolute and relative wall thickness (0.45 ± 0.07 vs. 0.39 ± 0.04, p &lt; 0.001), worsening of diastolic indices (e’ velocity 9.2 ± 2.2 vs. 11.3 ± 2.6 cm/s, p &lt; 0.001, E/e’ ratio 7.5 ± 1.8 vs. 6.8 ± 1.7, p = 0.002) and global longitudinal strain (17.5 ± 2.4 vs. 18.6 ± 2.2, p &lt; 0.001). No significant improvement was found on re-evaluation at 1 month.ConclusionsHospitalized patients recovering from COVID-19 were characterized by a high prevalence of left ventricular concentric remodeling, predominantly Grade I diastolic dysfunction, and a mild decrease in the longitudinal systolic function. These changes were less frequent but still prevalent in the non-hypertensive subgroup and largely persisted throughout the 1-month follow-up.
Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study
Authors: Zhao Benzheng , Wang Zhenpeng , Liu Dongzhen , Zhang Songling 
Published: November 2023

BackgroundTestosterone plays a key role in women, but the associations of serum testosterone level with gynecological disorders risk are inconclusive in observational studies.MethodsWe leveraged public genome-wide association studies to analyze the effects of four testosterone related exposure factors on nine gynecological diseases. Causal estimates were calculated by inverse variance–weighted (IVW), MR–Egger and weighted median methods. The heterogeneity test was performed on the obtained data through Cochrane’s Q value, and the horizontal pleiotropy test was performed on the data through MR–Egger intercept and MR-PRESSO methods. “mRnd” online analysis tool was used to evaluate the statistical power of MR estimates.ResultsThe results showed that total testosterone and bioavailable testosterone were protective factors for ovarian cancer (odds ratio (OR) = 0.885, P = 0.012; OR = 0.871, P = 0.005) and endometriosis (OR = 0.805, P = 0.020; OR = 0.842, P = 0.028) but were risk factors for endometrial cancer (OR = 1.549, P &lt; 0.001; OR = 1.499, P &lt; 0.001) and polycystic ovary syndrome (PCOS) (OR = 1.606, P = 0.019; OR = 1.637, P = 0.017). dehydroepiandrosterone sulfate (DHEAS) is a protective factor against endometriosis (OR = 0.840, P = 0.016) and premature ovarian failure (POF) (OR = 0.461, P = 0.046) and a risk factor for endometrial cancer (OR= 1.788, P &lt; 0.001) and PCOS (OR= 1.970, P = 0.014). sex hormone-binding globulin (SHBG) is a protective factor against endometrial cancer (OR = 0.823, P &lt; 0.001) and PCOS (OR = 0.715, P = 0.031).ConclusionOur analysis suggested causal associations between serum testosterone level and ovarian cancer, endometrial cancer, endometriosis, PCOS, POF.
Effects of the Zishen Yutai Pill compared with placebo on pregnancy outcomes among women in a fresh embryo transfer cycle: a Post Hoc subgroup analysis of a randomized controlled trial
Authors: Chen Xiaoli , Li Yu , Zhou Jiewen , Wei Xuemei , Ning Na , Huang Qiuling , Pang Xiufei , Yang Dongzi 
Published: November 2023

ObjectiveTo assess whether the administration of Zishen Yutai Pill (ZYP) could improve the pregnancy outcomes in different subgroups of women undergoing fresh embryo transfer cycles.Materials and methodsThis is a post hoc analysis of a large scale, placebo-controlled, double blind, randomized clinical trial (RCT) regarding the use of ZYP during assisted reproductive technology (ART) treatment. The RCT was conducted at 19 in vitro fertilization (IVF) centers between April 2014 and June 2017. A total of 2265 women undergoing fresh embryo transfer cycles were randomly assigned in a 1:1 ratio to receive ZYP (n = 1131) or placebo (n = 1134). Post hoc logistic regression analyses were applied in this study to examine the between-group differences of ZYP and placebo on clinical pregnancy rate among different subgroups. Detailed analyses, both in intention-to-treat (ITT) and per-protocol population, were also conducted in specific subgroups with regards to rates of implantation, biochemical pregnancy, clinical pregnancy, live birth, pregnancy loss, as well as other neonatal indices.ResultsZYP showed a significantly higher clinical pregnancy rates than placebo in the ITT population. Detailed subgroup analyses were conducted in subgroup in advanced maternal age (AMA, ≥ 35 years old) and overweight/obese patients (BMI &gt; 24), due to the clinical importance and statistical results. In these subgroups, baseline characteristics were similar between two arms (all P &gt; 0.05). Significantly elevated clinical pregnancy rates were observed in ZYP cohort (both P &lt; 0.05) compared with the placebo group. Results also showed that ZYP treatment resulted in significantly higher rates of implantation, biochemical pregnancy in AMA or overweight/obese patients in ITT analysis (all P &lt; 0.05).ConclusionsThe current post hoc subgroup analysis suggested that AMA and overweight/obese women could experience clinical benefits when treated with ZYP in their fresh embryo transfer cycles. The study provides references for the use of ZYP in ART practices. However, further studies in specific subgroups should be examined in more rigorous clinical trial settings.Clinical trial registrationChictr.org.cn, ChictrTRC-14004494.
Role of leisure sedentary behavior on type 2 diabetes and glycemic homeostasis: a Mendelian randomization analysis
Authors: Jia Hui , Liu Yifan , Liu Dandan 
Published: November 2023

PurposeUtilize Mendelian randomization (MR) to examine the impact of leisure sedentary behavior (LSB) on the prevalence of type 2 diabetes mellitus (T2D) and glycemic homeostasis impairment, as well as to identify potential mediating pathways involved in these associations.MethodsWe chose genetic variants linked to LSB from a large genome-wide association study (GWAS) to use as instrumental variables (IVs). Then, we used a two-sample MR study to investigate the link between LSB and T2D and glycemic homeostasis. Multivariate MR (MVMR) and mediation analysis were also used to look at possible mediating paths.ResultsMR analysis showed a genetical link between leisure TV watching and T2D (OR 1.64, 95% CI 1.39-1.93, P&lt; 0.001) and impaired Glycemic Homeostasis, while leisure computer use seemed to protect against T2D prevalence (OR 0.65, 95% CI 0.50-0.84, P&lt; 0.001). It was found that leisure TV watching increases the risk of T2D through higher BMI (mediation effect 0.23, 95% CI 0.11-0.35, P&lt; 0.001), higher triglycerides (mediation effect 0.07, 95% CI 0.04-0.11, P&lt; 0.001), and less education (mediation effect 0.16, 95% CI 0.08-0.24, P&lt; 0.001). Sensitivity and heterogeneity analyses further substantiated the robustness of these findings. Reverse MR analysis did not yield significant results.ConclusionThis study shows LSB is linked to a higher rate of T2D and impaired glycemic homeostasis through obesity, lipid metabolism disorders, and reduced educational attainment.