bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of nursing student medication errors: A systematic review
Authors: Triantafyllou Christos , Gamvrouli Maria , Myrianthefs Pavlos 
Published: October 2023

Background: Health promotion and patient safety are the main targets of the healthcare provision by the National Health Systems. As for the nursing profession, nursing students make medication errors during clinical interventions, which could be a potential danger to patient safety. The investigation of the frequency of nursing student medication errors, as well as the frequency of each type of nursing student medication errors.
Method and Material: A systematic review of the literature was conducted on the electronic database "PubMed" with the keywords: "medication error", "prescribing error", "drug error", "drug use error", "drug mistake", "wrong drug", "wrong dose", "administration error", "dispensing error", "incorrect drug", "incorrect dose", "inappropriate prescribing", "inappropriate medication", "transcription error", "nursing student", "nursing trainee" and on the Greek electronic database IATROTEK-online with the keywords: "medication errors" and "nursing students", without time limit for the publication of scientific papers. On PubMed, the keywords were searched in the title and abstract of the studies. Studies were excluded if they were not published in English and Greek language, were conducted on animals, and were case studies, editorials, and letters to the editor.
Results: Of the 47 scientific papers retrieved, 6 were included in the systematic review. A total of 1,904 nursing student medication errors were recorded by nursing students. The majority of errors were: 1) wrong dose form (330,17%), 2) omission error (313, 16.4%), and 3) wrong time (259, 13.6%).
Conclusions: The frequency of nursing student medication errors is high. The safe administration of medications is an important skill that nursing students should learn. medication administration.
Comprehensive program development for congenital heart disease in the United Arab Emirates and in Singapore
Authors: Kiraly Laszlo , Aye Maung Maung Winn , Subbian Senthil Kumar , Shah Nishant Chandrakant , Hetharsi Balazs , Al Hakami Aref Mohammed , Kofidis Theo 
Published: October 2023

Background/Objective. Establishment and development of tertiary-care centres for congenital heart disease (CHD) face multiple challenges as they need to be accessible, affordable/sustainable and provide the best possible outcomes. We report our experience of foundation a new tertiary-care CHD centre in the United Arab Emirates (UAE) and program development in Singapore.
Methods. Prevalence and incidence of CHD in the context of local sociocultural environment was reviewed. Having established program elements of team, premises and workflow, quality assurance system was established. Outcome analysis, continuous audit modified internal therapeutic policies in accordance to international databases.
Results. Consanguinity, segregated pattern of the population, high birth rate and low prenatal screening rate increased the incidence/prevalence and complexity of CHD in the UAE. Higher complexity/redo presentation and presence of associated anomalies were prevalent in Singapore at a lower birth rate. Increasing patient-load, strict professional working environment, strong governmental financial mandate for care nominated our centre into a market-leading position in the UAE. Singapore has a highly-developed, regulated, still competitive healthcare infrastructure that represents challenges for program development. Additional surgical activity from underserviced regions could provide the adequate CHD patient-pool that is critical to achieve team-expertise and ensure the best possible patient and program outcomes.
Conclusion. CHD has significant public health aspects, however, new and/or developing centres face different challenges depending on the sociocultural and economic environment they function in. External demographic factors, case-load, complexity, referral patterns, health-care financing structure are difficult to adjust; internal factors: program structure, quality assurance, professional working framework are subjects for improvement.
Mehr als Vollzeit: Fractional CIOs in KMUs
Authors: Kratzer Simon , Westner Markus , Strahringer Susanne 
Published: October 2023

ZusammenfassungAuch kleine und mittlere Unternehmen (KMUs) benötigen zunehmend ein effektives Informationstechnologie- (IT)-Management, um wettbewerbsfähig zu bleiben. Im Vergleich zu großen Unternehmen verfügen KMUs jedoch oft nicht über die Ressourcen, die Arbeitgeberattraktivität oder den Bedarf, um einen Chief Information Officer (CIO) in Vollzeit zu beschäftigen. Um diese Lücke zu schließen, hat eine wachsende Zahl von Expertinnen und Experten weltweit damit begonnen, CIO-Dienste in Teilzeit anzubieten. Auf diese Weise erhalten KMUs Zugang zu erfahrenen und kompetenten IT-Führungskräften zu einem Bruchteil der Kosten und ohne langfristige Verpflichtungen. Während diese so genannten „Fractional CIOs“ in der Praxis bereits einen Mehrwert schaffen, gibt es noch kaum wissenschaftliche Untersuchungen zu diesem neuen Phänomen. In einem größeren Forschungsprojekt mit insgesamt 62 Fractional CIOs aus 10 Ländern wurden daher eine Definition, Typen verschiedenartiger Engagements und Erfolgsfaktoren abgeleitet. Die vorliegende Studie fasst die Ergebnisse zusammen und setzt sie in Bezug zum deutschen Markt, indem sie drei Fractional CIOs/CTOs aus Deutschland befragt. Es zeigt sich, dass die folgenden vier Engagement-Typen von Fractional CIOs für KMUs in verschiedenen Situationen von Nutzen sind: Strategisches IT-Management, Restrukturierung, Skalierung und Hands-on Support. Darüber hinaus zeigt die Studie, dass Vertrauen, die Unterstützung durch das Top-Management-Team und die Integrität des Fractional CIOs Schlüsselfaktoren für den Erfolg von Fractional CIO-Engagements sind. Für den deutschen Markt werden die Ergebnisse durch drei befragte Fractional CIOs/CTOs weitgehend bestätigt. Die Fractional CIOs/CTOs können zwar keine genauen Gründe für die geringe Akzeptanz der Rolle nennen, betonen aber ihr Wertpotenzial für den deutschen Markt.
Patient preferences and cost-benefit of hypertension and hyperlipidemia collaborative management model between pharmacies and primary care in Portugal: A discrete choice experiment alongside a trial (USFarmácia®)
Authors: Costa Suzete , Guerreiro José , Teixeira Inês , Helling Dennis K. , Mateus Céu , Pereira João 
Published: October 2023

Background
Little is known about patient preferences and the value of pharmacy-collaborative disease management with primary care using technology-driven interprofessional communication under real-world conditions. Discrete Choice Experiments (DCEs) are useful for quantifying preferences for non-market services.

Objectives
1) To explore variation in patient preferences and estimate willingness-to-accept annual cost to the National Health Service (NHS) for attributes of a collaborative intervention trial between pharmacies and primary care using a trial exit DCE interview; 2) to incorporate a DCE into an economic evaluation using cost-benefit analysis (CBA).

Methods
We performed a DCE telephone interview with a sample of hypertension and hyperlipidemia trial patients 12 months after trial onset. We used five attributes (levels): waiting time to get urgent/not urgent medical appointment (7 days/45 days; 48 hrs./30 days; same day/15 days), model of pharmacy intervention (5-min. counter basic check; 15-min. office every 3 months for BP and medication review of selected medicines; 30-min. office every 6 months for comprehensive measurements and medication review of all medicines), integration with primary care (weak; partial; full), chance of having a stroke in 5 years (same; slightly lower; much lower), and annual cost to the NHS (0€; 30€; 51€; 76€). We used an experimental orthogonal fractional factorial design. Data were analyzed using conditional logit. We subtracted the estimated annual incremental trial costs from the mean WTA (Net Benefit) for CBA.

Results
A total of 122 patients completed the survey. Waiting time to get medical appointment—on the same day (urgent) and within 15 days (non-urgent)—was the most important attribute, followed by 30-minute pharmacy intervention in private office every 6 months for point-of-care measurements and medication review of all medicines, and full integration with primary care. The cost attribute was not significant. Intervention patients were willing to accept the NHS annual cost of €877 for their preferred scenario. The annual net benefit per patient is €788.20 and represents the monetary value of patients’ welfare surplus for this model.

Conclusions
This study is the first conducted in Portugal alongside a pharmacy collaborative trial, incorporating DCE into CBA. The findings can be used to guide the design of pharmacy collaborative interventions with primary care with the potential for reimbursement for uncontrolled or at-risk chronic disease patients informed by patient preferences. Future DCE studies conducted in community pharmacy may provide additional contributions.

Trial registration
Current Controlled Trials (ISRCTN): ISRCTN13410498, retrospectively registered on 12 December 2018.
Objectively and subjectively measured physical activity levels in individuals with whiplash associated disorder and aged-matched healthy controls
Authors: Ritchie Carrie , Smits Esther , Armfield Nigel , Sterling Michele 
Published: October 2023

Background
Whiplash associated disorders (WAD) are the most common non-hospitalised injuries resulting from a motor vehicle crash. Half of individuals with WAD experience ongoing pain and disability. Furthermore, individuals with persistent WAD have lower levels of aerobic capacity and isometric strength compared with age-matched controls. It is not known whether these differences are associated with increased levels of pain and disability, or with reduced physical activity (PA) participation.

Objective
Our primary aim was to compare PA levels in individuals with persistent WAD with healthy controls. Secondary aims were to: compare objective and subjective measurements of PA; explore factors that may influence PA; and describe proportions of these populations meeting World Health Organisation PA guidelines.

Methods
Objective (ActiGraph accelerometer; seven days) and subjective (International Physical Activity Questionnaire (IPAQ)) PA data were collected for n = 53 age-matched participants (WAD n = 28; controls n = 25).

Results
Independent sample t-tests showed no significant difference in objectively measured PA (p>0.05) between WAD and controls. For the subjective measure (IPAQ), controls reported more overall weekly PA (t = 0.219, p<0.05), while WAD participants reported more weekly walking minutes (t = -0.712, p<0.05). Linear regression showed mental health quality-of-life predicted objectively measured moderate intensity PA (R2 = 0.225, F (2, 44) = 6.379, p<0.004) and subjectively reported overall PA (R2 = 0.132, F (1, 41) = 6.226, p<0.017). Bland-Altman analyses indicated that subjects over-reported MVPA and under-reported sedentary time using the IPAQ.

Conclusions
Individuals with WAD had levels of physical and mental health quality-of-life significantly lower than controls and below population norms yet participated in similar levels of PA. Given that increased perceptions of mental health quality-of-life were positively associated with objectively measured MVPA and subjectively reported overall PA, strategies to help people with WAD achieve adequate doses of MVPA may be beneficial. ActiGraph-measured and IPAQ-reported PA were discordant. Hence, IPAQ may not be a reliable measure of habitual PA in WAD.
Statute of Limitations for Restitution Claims after a Term is Declared Unfair. Some Remarks on the CJEU Judgment of 8th of September 2022 (Joined Cases C-80/21 to C-82/21)
Authors: Gutowski Maciej 
Published: October 2023

Abstract
The article refers to the problem of Statute of limitations for restitution claims after a term is declared unfair in light of the ECJ judgment of 8th of September 2022 (Joined Cases C-80/21 to C-82/21). In light of the ECJ judgment one may not argue that if there was a sanction that would deprive a consumer effective claim for restitution because of excessive effect of statute of limitation, such mechanism would be contrary to the aim of protection under Directive 93/13. The regulation contained in Directive 93/13 should not allow for 10‑year limitation period for a consumer’s action for the restitution of the payments made under 30-years lasting bank loan contract if the limitation period passed before the consumers claim has been payable. The ECJ judgment might be perceived as somewhat superfluous, because such an effect would also be difficult to accept that in the light of the principles of the civil law – certainly Polish law, which should give a ground for the assumption provided in the question submitted by the referring court. However, the ECJ ruling itself does not seem to be controversial.
“The unlikeliest twins”: the role of intertextual foregrounding and defamiliarisation in creating empathy in Meursault, contre-enquête
Authors: Karpenko-Seccombe Tatyana 
Published: October 2023

Abstract
Kamel Daoud’s debut novel Meursault, contre-enquête is a recasting of Camus’ seminal novel, L’Étranger. Daoud creates an overt and deliberate set of intertextual references to Camus’ text by describing the same events from the point of view of the brother of the nameless ‘Arab’ murdered by Meursault in L’Étranger. Thus the differences in character and event presentation are defamiliarised and foregrounded. This article argues that such intertextual foregrounding and defamiliarisation has implications for reader identification with the characters and related empathetic responses. Using a corpus-assisted stylistic analysis of the original French texts, the article illustrates these implications by analysing the ways the language of Daoud’s novel may contribute to alternation between readers’ empathy and antipathy towards its characters.
Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
Authors: Peng Yiyan , Li Peng , Hu Wei , Shao Qi , Li Panpan , Wen Haiyue 
Published: October 2023

Abstract
Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)? In our research, 16 beagles were randomly divided into a rapid atrial pacing (RAP) group (n = 8) and a RAP + SCS group (n = 8), and the effective refractory period (ERP), ERP dispersion, AF induction rate, and AF vulnerability window (WOV) at baseline, 6 h of RAP, 6 h of RAP + SCS were measured. The atrial tissue was then taken for immunohistochemical analysis to determine the localization of ET-1, NGF, p75NTR, NF-kB p65, and other genes. Our results showed that SCS attenuated the shortening of ERP in all parts caused by RAP, and after 6 h of SCS, the probability of AF in dogs was reduced compared with that in the RAP group. Moreover, the expression of ET-1, NGF, and p75NTR in the atrial tissues of dogs in the RAP + SCS group was significantly increased, but the expression of NF-kB p65 was reduced. In conclusion, SCS promotes the positive remodeling of cardiac autonomic nerves by weakening NFκB p65-dependent pathways to interfere with the ET-1 and NGF/p75NTR pathways to resist the original negative remodeling and inhibit the occurrence of AF.
Factors associated with gastrointestinal dysmotility in critically ill patients
Authors: Petrović Nemanja , Žunić Miodrag , Pejčić Ana , Milosavljević Miloš , Janković Slobodan 
Published: October 2023

Abstract
Critical illness may disrupt nutritional, protective, immune, and endocrine functions of the gastrointestinal tract, leading to a state of gastrointestinal dysmotility. We aimed to identify factors associated with the occurrence of gastrointestinal dysmotility in critically ill patients. A cross-sectional retrospective study was conducted, using patient files as a source of data. The study included 185 critically ill patients treated in the intensive care unit of the University Clinical Center, Kragujevac, Serbia, from January 1, 2016, to January 1, 2022. Significant risk factors associated with some form of gastrointestinal dysmotility were acute kidney injury (with paralytic ileus, nausea, vomiting, and constipation), recent abdominal surgery (with ileus, nausea, vomiting, and constipation), mechanical ventilation (with ileus, and nausea), age (with ileus and constipation), and use of certain medication such as opioids (with ileus, gastro-esophageal reflux, nausea, vomiting, and constipation), antidepressants (with ileus, nausea, and vomiting), and antidiabetics (with ileus). On the other hand, Charlson comorbidity index had divergent effects, depending on the form of gastrointestinal dysmotility: it increased the risk of gastro-esophageal reflux but protected against ileus, nausea, and vomiting. In clonclusion, recognition of factors associated with gastrointestinal dysmotility should initiate preventative measures and, thus, accelerate the recovery of critically ill.
Simulation of three-dimensional temperature field in high-frequency welding based on nonlinear finite element method
Authors: Tang Lun , Yang Minge , Hou Zhihua 
Published: October 2023

Abstract
In modern industrial production, many advanced manufacturing technologies are constantly developing with the progress of social sciences. Welding, as an indispensable manufacturing technology in industrial production, has received close attention from various industries. High frequency welding technology is needed in fields such as mechanical manufacturing, machine making in the food industry, and intelligent robot model making. High frequency welding is an important technical means in the production process of welded pipes, and the level of welding temperature has a significant impact on the quality of welded pipe welds. This article studied the shortcomings of traditional high-frequency welding, analyzed the application method of nonlinear finite element method in high-frequency welding, and analyzed the dynamic process of welding and its influencing factors. The finite element method formula is used to stabilize the value of three-dimensional (3D) temperature field. This work studied the temperature distribution of welded pipe welding, welded pipe materials, inside and outside of welded pipe, and temperature changes under different voltages. The experimental results showed that the error value between the simulation results of the 3D temperature field of high-frequency welding and the measured experimental results was about 4.3542°C, which was basically similar, indicating the effectiveness of the 3D temperature field simulation experiment. With the development of science and technology, high-frequency welding technology would continue to improve, and the quality of welded pipe welds would become better and better with the progress of technology. The improvement in quality promotes the development and progress of industry, and maintains the quality of machine manufacturing. The simulation experiment method of 3D temperature field has shortened the experimental time and reduced the experimental cost, providing a new reference for other temperature related experiments.
Extraction of some univalent and divalent cations into nitrobenzene in the presence of calcium ionophore I
Authors: Vaňura Petr , Makrlík Emanuel 
Published: October 2023

Abstract
The stability constants of the Calcium ionophore I (i.e., N,N´ – di[(11′- ethoxycarbonyl) undecyl] – N,N′,4,5 -tetramethyl – 3,6 – dioxaoctane diamide) complexes with Mn+ (Mn+ = Li+, H3O+, Na+, NH4
+, Ag+, K+, Rb+, Tl+, Cs+, Ca2+, Sr2+, Ba2+. Pb2+, Cu2+, Zn2+) in nitrobenzene saturated with water were determined by the extraction method. These constants were found to increase in the series of Cs+ < Rb+ < K+ < NH4
+ < Na+ < Tl+ < H3O+ < Ag+ < Li+ and Ba2+ < Zn2+ < Sr2+ < Pb2+ < Cu2+< Ca2+.
Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons
Authors: Dorskind Joelle M. , Sudarsanam Sriram , Hand Randal A. , Ziak Jakub , Amoah-Dankwah Maame , Guzman-Clavel Luis , Soto-Vargas John Lee , Kolodkin Alex L. 
Published: October 2023

Proper cortical lamination is essential for cognition, learning, and memory. Within the somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a laminar-specific manner that dictates synaptic partners and overall circuit organization. Here, we leverage both male and female mouse models, single-cell labeling and imaging approaches to identify intrinsic regulators of laminar-specific collateral, also termed interstitial, axon branching. We developed new approaches for the robust, sparse, labeling of Layer II/III pyramidal neurons to obtain single-cell quantitative assessment of axon branch morphologies. We combined these approaches with cell-autonomous loss-of-function (LOF) and overexpression (OE) manipulations in anin vivocandidate screen to identify regulators of cortical neuron axon branch lamination. We identify a role for the cytoskeletal binding protein drebrin (Dbn1) in regulating Layer II/III cortical projection neuron (CPN) collateral axon branchingin vitro. LOF experiments show that Dbn1 is necessary to suppress the elongation of Layer II/III CPN collateral axon branches within Layer IV, where axon branching by Layer II/III CPNs is normally absent. Conversely,Dbn1OE produces excess short axonal protrusions reminiscent of nascent axon collaterals that fail to elongate. Structure-function analyses implicate Dbn1S142phosphorylation and Dbn1 protein domains known to mediate F-actin bundling and microtubule (MT) coupling as necessary for collateral branch initiation uponDbn1OE. Taken together, these results contribute to our understanding of the molecular mechanisms that regulate collateral axon branching in excitatory CPNs, a key process in the elaboration of neocortical circuit formation.SIGNIFICANCE STATEMENTLaminar-specific axon targeting is essential for cortical circuit formation. Here, we show that the cytoskeletal protein drebrin (Dbn1) regulates excitatory Layer II/III cortical projection neuron (CPN) collateral axon branching, lending insight into the molecular mechanisms that underlie neocortical laminar-specific innervation. To identify branching patterns of single cortical neuronsin vivo, we have developed tools that allow us to obtain detailed images of individual CPN morphologies throughout postnatal development and to manipulate gene expression in these same neurons. Our results showing that Dbn1 regulates CPN interstitial axon branching both invivoand invitromay aid in our understanding of how aberrant cortical neuron morphology contributes to dysfunctions observed in autism spectrum disorder and epilepsy.