bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review
Authors: Specht Bernhard , Jager Hana , Garbaya Samaher , Pincherle Alessandro , Sarvari Peiman Alipour , Khadraoui Djamel , Schneider Reinhard , Chavarriaga Ricardo , Tayeb Zied 
Published: November 2023

ABSTRACTIn recent times, we have unequivocally witnessed a push towards digitising the healthcare system. Topics such as remote patient monitoring (RPM), digital health, and their use to monitor neurological disease progression have gained momentum and popularity. Notwithstanding the considerable advances that have been made in adopting such technologies and using them in the context of mental health or even a few neurodegenerative disease monitoring, they have not been widely used in the context of remote management and treatment of multiple sclerosis MS. In the same vein, given that (MS) is a very individualized disease to manage, there are numerous challenges yet opportunities associated with using digital health technologies for remote MS monitoring. This paper reviews the different research work and clinical attempts performed over the last decade (both home & hospital-based monitoring) en route to using digital health for MS monitoring and management. Similarly, this systematic review discusses the main challenges and barriers to translating that research from clinics into homes and highlights the opportunities in that context. Throughout this extensive review, we shine a light on various monitoring methods that hold the potential to be measured in a home environment, including electroencephalography (EEG) and evoked potentials (e.g., motor evoked potential (MEP), somatosensory evoked potentials (SSEP), and visual evoked potential (VEP)), electromyography (EMG), inertial measurement unit (IMU), and speech analysis. Combining such digital biomarkers could pave the way for developing a more personalised treatment for MS patients, thereby stopping its progression and avoiding silent MS disability. Adopting digital health for remote monitoring and management could also chart a route ahead for a new era of personalised medicine for MS patients and potentially other brain disorder patients.
Understanding consumers' interest in social commerce: the role of privacy, trust and security
Authors: Tseng Hsiao-Ting , Nadeem Waqar , Hajli M. Sam , Featherman Mauricio , Hajli Nick 
Published: November 2023

PurposeConsumers may enjoy the information sharing and social support made available when a social media platform is used for pre-purchase research; however, do consumers reevaluate the privacy and security of the platform differently when ordering and payment capabilities are added? As social media systems have evolved into social commerce platforms (SCPs), individuals are often faced with whether to complete a purchase they have been researching or switch to a traditional e-commerce platform to complete the transaction. This research examines consumer trust formation in the SCP channel and how consumer interest and engagement in the channel are maintained and influence consumer decisions to purchase via the SCP.Design/methodology/approachBased on trust and involvement literature, a research model was conceptualized to capture consumer beliefs about SCP privacy and security and whether the SCP can be trusted, using these inputs into subsequent consumer interest, engagement and decisions on whether to use the SCP for purchasing. The research model was empirically tested using the panel data's structural equation modeling (AMOS) (n = 405). The data showed acceptable reliability and convergent validity, while the original research model provides predictive validity and theory-confirming insights.FindingsResults confirm that consumer perceptions of privacy and security play a crucial role as decision criteria, informing their judgments of whether a new social commerce channel can be trusted enough to conduct purchases. Further, consumer trust supports their interest in the SCP, resulting in enduring and enhanced behavioral use and, to a lesser extent, purchase intent. Still, a majority of this sample declined to purchase using the SCP and rather preferred to transact on tried and trusted traditional e-commerce sites.Originality/valueThis study is among the first to examine trust formation in new SCPs, where consumers are deciding to expand their engagement level from social and informational to commercial.
Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta‐analysis
Authors: Lee Carmen M. , Dillon David G. , Tahir Peggy M. , Murphy Charles E. 
Published: November 2023

AbstractObjectiveDespite frequent treatment of alcohol withdrawal syndrome (AWS) in the emergency department (ED), evidence for phenobarbital (PB) as an ED alternative therapy is mixed. We conducted a systematic review and meta‐analysis comparing safety and efficacy of PB to benzodiazepines (BZDs) for treatment of AWS in the ED.MethodsWe searched articles and references published in English in PubMed, Web of Science, and Embase from inception through May 2022. We included randomized trials and cohort studies comparing treatment with PB to BZD controls and excluded studies focused on non‐AWS conditions. Review was conducted by two blinded investigators and a third author; eight of 59 (13.6%) abstracts met inclusion criteria for review and meta‐analysis using a random‐effects model. Treatment superiority was evaluated through utilization, pharmacologic, and clinical outcomes. Primary outcomes for meta‐analysis were the proportion of patients (1) admitted to the intensive care unit (ICU), (2) admitted to the hospital, (3) readmitted to the ED after discharge, and (4) who experienced adverse events.ResultsEight studies (two randomized controlled trials, six retrospective cohorts) comprised data from 1507 patients in 2012 treatment encounters for AWS. All studies were included in meta‐analysis for adverse events, seven for hospital admission, five for ICU admission, and three for readmission to the ED after discharge. Overall methodological quality was low‐moderate, risk of bias moderate‐high, and statistical heterogeneity moderate. Pooled relative risk of ICU admission for those treated with PB versus BZD was 0.92 (95% confidence interval [CI] 0.54–1.55). Risk for admission to the hospital was 0.98 (95% CI 0.89–1.07) and for any adverse event was 1.1 (95% CI 0.78–1.57); heterogeneity prevented meta‐analysis for ED readmission.ConclusionsThe current literature base does not show that treatment with PB significantly reduces ICU admissions, hospital admissions, ED readmissions, or adverse events in ED patients with AWS compared with BZDs alone.
Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips
Authors: KALSNER S. 
Published: November 2023

Summary
Caffeine and theophylline increased the amplitude of contractor esponses of untreated and reserpine pretreated rabbit aortic strips to catecholamines (adrenaline, α‐methylnoradrenaline, noradrenaline). Responses to amines without both the 3‐ and 4‐OH groups in the benzene ring (methoxamine, phenylephrine, Synephrine) were not increased by theophylline and only those to Synephrine were slightly enhanced by caffeine.
Compounds which inhibit catechol‐O‐methyltransferase (pyrogallol, tropolone, U‐0521) potentiated responses to catecholamines and abolished the enhancing effect of theophylline and caffeine. Also, the potentiation produced by inhibitors of O‐methylation was significantly reduced in the presence of the methylxanthines.
Experiments done with the aid of the technique of oil immersion, to eliminate the diffusion of drug from the tissue into the bathing medium, showed that theophylline and caffeine decreased the rate of inactivation of adrenaline by O‐methylation.
These findings indicate that methylxanthines potentiate the contractor responses to catecholamines in aortic strips by inhibiting their extraneuronal inactivation.
Accuracy of digital duplication scanning methods for complete dentures
Authors: Alehaideb Abdullah , Lin Wei‐Shao , Levon John A. , Chu Tien‐Min G. , Yang Chao‐Chieh 
Published: November 2023

AbstractPurposeTo compare the accuracy of four digital scanning methods in duplicating a complete denture.Material and MethodsFour scanning methods were used: cone beam computed tomography (CBCT), Straumann desktop scanner (DS), Trios intraoral scanner (TIO), and Virtuo Vivo intraoral scanner (VVIO). Each method was used to duplicate all the surfaces of a printed complete denture. The denture was scanned 10 times in each group. The trueness (in root mean square, RMS) and precision (in standard deviation, SD) were calculated by comparing the combined dentition, denture extension, and intaglio surfaces with the reference file. One‐way analysis of variance and F‐tests were used to test statistical differences (α = 0.05).ResultsFor the scanning accuracy of the whole denture, CBCT showed the highest RMS (0.249 ± 0.020 mm) and lowest trueness than DS (0.124 ± 0.014 mm p < 0.001), TIO (0.131 ± 0.006 mm p < 0.001), and VVIO (0.227 ± 0.020 mm p = 0.017), while DS and TIO showed smaller RMS than VVIO (p < 0.001). For the trueness of dentition, denture extension, and intaglio surfaces, CBCT also showed the highest mean RMS and lowest trueness among all groups (p < 0.001). DS and TIO had smaller mean RMS and higher trueness among all groups in all surfaces (p < 0.001, except VVIO in intaglio surface, p > 0.05). TIO had significantly lower within‐group variability of RMS and highest precision compared to DS (p = 0.013), CBCT (p = 0.001), and VVIO (p < 0.001) in the combined surface. For dentition and denture extension surfaces, TIO showed similar within‐group variability of RMS with the DS group (p > 0.05) and lower than CBCT and VVIO (p < 0.001).ConclusionThe 7 Series desktop scanner and Trios 4 intraoral scanner can duplicate dentures in higher trueness than CBCT and the Virtuo Vivo intraoral scanner. The Trios 4 intraoral scanner was more precise in the combined surfaces than other scanning methods, while the 7 Series desktop scanner and Trios 4 intraoral scanner were more precise in the denture extension surface.
Supersymmetric higher-derivative models in quantum cosmology
Authors: Martínez-Pérez Nephtalí Eliceo , Ramírez Cupatitzio 
Published: November 2023

AbstractWe study the quantum cosmology of supersymmetric, homogeneous and isotropic, higher derivative models. We recall superfield actions obtained in previous works and give classically equivalent actions leading to second order equations for the bosons, and first order for the fermions. Upon quantization, the algebra of fermions leads to a multi-component state, which is annihilated by the Hamiltonian and supersymmetric constraint operators. We obtain asymptotic wave functions of the oscillatory type, whose classical limit corresponds to inflationary evolution, and exact exponential wave functions. We use the latter to derive probability distributions of the initial curvature that are compatible with those obtained using the non-supersymmetric model.
The relationship of body colouration to morphological traits in a population of green frogs from Georgia, USA
Authors: Stephenson Barry P. , Christensen Jorden 
Published: November 2023

Abstract
Sexually dimorphic body colouration can serve to signal quality in vertebrates, but less is known about its importance in amphibians when compared to some other groups. The green frog (Lithobates clamitans) is a common anuran of aquatic habitats in eastern North America. In adults of both sexes, the dorsal abdomen is green or brown, and the ventral abdomen usually white. In contrast, throat colouration is sexually dimorphic; adult male throats are usually bright yellow in colour, whereas females and some males express white throats. We assessed body colouration in males and females from a population in Georgia, USA using spectrophotometry to quantify variation in these features and determine if hidden dimorphism was present. We then asked whether this spectral variation correlated with aspects of phenotype linked to fitness in anurans. Male throats were higher in Green-Yellow Chroma and lower in UV Chroma than those of females, but the sexes did not differ in ventral or dorsal abdominal colour. Male SVL was related to ventral abdominal colouration; larger males tended to have ventral abdomens with longer-wavelength Hue and reduced Green-Yellow Chroma compared to smaller males. However, throat or dorsal abdominal colouration was unrelated to any morphometric trait examined in either sex. Overall, variation in male throat and abdominal colour was only weakly related to indices of male quality; instead, we hypothesize that the persistence of white-throated males in populations throughout the range of green frogs is related to the presence of sex-reversed males and intersex individuals recently described from other populations.
The Alchemies of Science: The Kīmīyā Concept Across Persian and Urdu Intellectual Worlds
Authors: Siddiqui Osama 
Published: November 2023

Abstract
This article explores the transformation of the kīmīyā concept across Persian and Urdu intellectual worlds in South Asia. It shows how kīmīyā, a premodern alchemical tradition, transformed in the nineteenth century to become the primary Urdu translative equivalent to chemistry and a popular synonym for wealth. The article argues that these changes were a result of changing conditions of knowledge production, specifically the expansion of print, as well as the arrival of new forms of knowledge, such as chemistry and political economy. In doing so, the article offers a new case study to think about the semantic and conceptual transformation of premodern bodies of scientific knowledge in colonial modernity.
State Priorities and Needs: The Role of Block Grants
Authors: Balio Casey P. , Mathis Stephanie M. , Francisco Margaret M. , Meit Michael , Beatty Kate E. 
Published: November 2023

Objectives: Block grant funding provides federal financial support to states, with increased flexibility as to how those funds can be allocated at the community level. At the state level, block grant amounts and distributions are often based on outdated formulas that consider population measures and funding environments at the time of their creation. We describe variation in state-level funding allocations for 5 federal block grant programs and the extent to which funding aligns with the current needs of state populations. Methods: We conducted an analysis in 2022 of state block grant allocations as a function of state-level characteristics for 2015-2019 for all 50 states. We provide descriptive statistics of state block grant allocations and multivariate regression models for each program. Models include base characteristics relevant across programs plus supplemental characteristics based on program-specific goals and state population needs. Results: Mean state block grant allocations per 1000 population by program ranged from $618 to $21 528 during 2015-2019. Characteristics associated with state allocations varied across block grants. For example, for every 1-percentage-point increase in the percentage of the population living in nonmetropolitan areas, Preventive Health and Health Services Block Grant funding was approximately $7 per 1000 population higher and Community Services Block Grant funding was approximately $40 per 1000 population higher. Few supplemental characteristics were associated with allocations. Conclusions: Current block grant funding does not align with state characteristics and needs. Future research should consider how funds are used at the state level or allocated to local agencies or organizations and compare state block grant allocations with other types of funding mechanisms, such as categorical funding.
Trends in Hepatitis C Virus and HIV Care Outcomes Among People With HIV in Georgia, United States, 2014-2019
Authors: Evans Kimberly N. , Wortley Pascale M. , Gandhi Ami , Bradley Heather 
Published: November 2023

Objective: If untreated, hepatitis C virus (HCV) leads to poor health outcomes, including liver disease and death, particularly among people with HIV (PWH). We describe trends over time in incidence rates of HCV diagnoses among PWH in the state of Georgia. Methods: We constructed a retrospective cohort of PWH in Georgia by using matched HIV and HCV case surveillance data from people diagnosed with HCV infection from January 1, 2014, through December 31, 2019. We calculated annual incidence rates per 1000 person-years and estimated trends over time in HCV diagnoses among the cohort of PWH by demographic characteristics and HIV care outcomes using Poisson regression analysis, with α = .05 considered significant. Results: From 2014 through 2019, among 49 530 PWH in Georgia, 1945 (3.9%) were diagnosed with HCV infection. During this period, overall incidence per 1000 person-years of newly diagnosed HCV infection among PWH decreased from 8.7 to 4.5 ( P for trend < .001). However, from 2014 through 2019, the annual incidence rates of PWH who were newly diagnosed with HCV infection increased from 4.6 to 7.1 ( P for trend = .003) among people born from 1980 through 1989 and from 3.3 to 12.8 ( P for trend < .001) among people born in 1990 or later. Conclusion: Strategies are needed to increase prevention, diagnosis, and treatment of HIV/HCV coinfection, particularly among PWH born in 1980 and later. Routine linkage of state surveillance data can inform prioritization of PWH at highest risk of HCV infection.
Comparison of Size of Posterior Tibial Slope and Medial Tibial Depth in Patients With an Isolated Meniscal Tear Requiring Surgery and Matched Uninjured Controls
Authors: Barnett Samuel C. , Portila Gabriella , Sanborn Ryan , Perone Gabrielle S. , Emami Alex , Kiapour Ata M. 
Published: November 2023

Background: Meniscal injuries are extremely common. Several anatomic features of the knee, including the tibial plateau morphology, have been shown to influence knee biomechanics and the risk of ligamentous injuries. Little is known, however, how these morphological features influence the risk of isolated meniscal injuries in the anterior cruciate ligament (ACL)–intact knee. Hypothesis: There are differences in the slopes and concavity of the tibial plateau between patients with isolated meniscal tears and matched uninjured controls. Study Design: Cohort study; Level of evidence, 3. Methods: In total, 89 patients with first-instance isolated medial (n = 37) or lateral (n = 52) meniscal injuries requiring surgical treatment (mean age, 16 ± 1 years; 35% female) were matched to 89 controls with uninjured knees and no previous injuries (mean age, 16 ± 2 years; 35% female) based on age and sex. Magnetic resonance imaging scans (preoperative for injured group) were used to measure the coronal slope of the tibial plateau, posterior slope of the medial and lateral tibial plateaus, and maximum depth of the medial tibial plateau. General linear models were used to evaluate the differences in tibial plateau morphology between the knees with and without meniscal injuries, with and without adjustment for age and sex. Results: Compared with matched controls, patients with surgically treated isolated meniscal tears had a smaller lateral tibial slope (by 2.2° [medial meniscal injury] and 1.6° [lateral meniscal injury]; P < .02), a smaller medial tibial slope (by 2.3° [medial meniscal injury] and 2.4° [lateral meniscal injury]; P < .001) and a larger medial tibial depth (by 0.8 mm [medial meniscal injury] and 0.9 mm [lateral meniscal injury]; P < .001). There were no differences in coronal tibial slope between the injured and uninjured groups. There were no differences in quantified anatomic features between the isolated medial and lateral meniscal injury groups. The same trends were observed after adjusting for age and sex. Conclusion: This study suggests that patients with an isolated meniscal tear requiring surgery have a smaller posterior tibial slope and a larger medial tibial depth (more concave medial tibial plateau) than matched uninjured controls. This is contrary to what is known for ACL tears, in which a steeper posterior tibial slope and a shallower medial tibial depth have been associated with an increased risk of ACL tear.
Harness collaboration between manufacturing Small and medium-sized enterprises through a collaborative platform based on the business model canvas
Authors: Proulx Mélick , Gardoni Mickaël 
Published: November 2023

Innovation, open innovation, and collaborative platforms are concepts in effervescence in the last few years. Innovation’s future will observe a growing number of collaborations. The links between collaboration and collaborative platforms are known in the transport and accommodation sector (such as Uber) however are less used in manufacturing. This paper aims to identify the main challenges between manufacturing firms which intend to collaborate enabled by a prototype platform. A collaborative business model was designed using the business model canvas and tested using a real case to generate valuable collaboration. Collaboration experimentation was monitored over 21 weeks between two firms of the Quebec aerospace cluster and ended with a semi-structured interview. Six challenges were identified: partner selection, commitment and trust, intellectual property management, collaboration evaluation, collaboration symmetry and terminology difficulties. Suggested solutions included, compatibility criteria between the partners, creating a vocabulary lexicon, and establishing collaboration expectations prior to collaboration.
Gross motor trajectories of pre-term and full-term infants under different parental educational approaches
Authors: Francisco Anilsa Suraia Pedro Gaspar , Graciosa Maylli Daiani , Pacheco Sheila Cristina da Silva , Sanada Luciana Sayuri 
Published: November 2023

This study aimed to explore motor trajectories of Brazilian pre-term and full-term infants from 3 to 12 months old whose parents participated in an educational program and had received guidance on gross motor development. Forty-eight Brazilian infants aged 3 months old were divided into Group 1 (full-term infants and their parents who received only verbal guidance, n = 14), Group 2 (full-term infants with parents who received an educative folder in addition to the same verbal guidance, n = 23), and Group 3 (preterm infants with parents who received the same verbal guidance and educative folder, n = 11). The folder had similar information to the verbal guidance; nonetheless, it helped to teach parents and allowed later consultation at home. We applied Alberta Infant Motor Scale, Affordances in Home Environment for Motor Development–Infant Scale, and a questionnaire about infants’ information at 3-, 6-, 9-, and 12-months old. In longitudinal comparison, all groups showed a significant difference for AIMS variables on total score and subscales; all subitems of AHEMD-IS; and time spent in prone, supine, sitting, and standing positions. In general, no differences were found between groups. Motor trajectory, home opportunities, and parental positioning practices were similar between full-term and preterm infants with different guidance approaches.