bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy
Authors: Wang Chengji , Qu Yuan , Shen Xiaoqin , Tang Xiaoxiao , Tong Gaiyu , Wati Meier , Naibi Manzeremu , Zhang Cheng , Zou Shaohong 
Published: January 2025

BackgroundAdolescent bipolar depression (ABD) refers to depressive episodes that arise in adolescent patients with bipolar disorder. Its identification and diagnosis are challenging, and it is characterized by a high rate of misdiagnosis and disability. Studies have revealed that patients with ABD are more prone to non-suicidal self-injury (NSSI) compared to those with unipolar depression. However, the neuropathophysiological mechanisms behind NSSI in ABD remain unclear. Therefore, this study employed proton magnetic resonance spectroscopy (1H-MRS) technology to investigate the potential relationship between NSSI and neurometabolism in the ventromedial prefrontal cortex (vmPFC) of patients with ABD.MethodsThis study compared brain biochemical metabolism between ABD with and without NSSI. Forty ABD were recruited and divided into groups with (n=21) and without NSSI (n=19). Proton magnetic resonance spectroscopy (1H-MRS) was used to detect the ratio of biochemical metabolites in the ventromedial prefrontal cortex (vmPFC) of all patients.ResultsThere was no statistically significant difference (P&gt;0.05) in the age, gender, only child status, residential status, education level, age of onset, disease course, family history, and 24-item Hamilton Depression Scale (HAMD) score between patients in the NSSI group and those without NSSI group. The N-acetylaspartate (NAA)/creatine (Cr) of patients with NSSI was lower than that of patients without NSSI, and the difference was statistically significant (Z=-4.347,P&lt;0.001). There was no statistically significant difference in choline (Cho)/Cr and myo-inositol (mI)/Cr between the group with NSSI and the group without NSSI (P&gt;0.05).There is a positive correlation (r=0.703,P&lt;0.00625) between Cho/Cr and HAMD scores in patients with NSSI, while there is a varying degree of negative correlation (r=-0.605,P=0.006;r=0.624,P=0.004) between mI/Cr and age and onset age in patients without NSSI. There is no correlation (P&gt;0.05) between other indicators.ConclusionCompared with ABD without NSSI, ABD with NSSI have reduced NAA/Cr metabolism in the vmPFC brain area. The level of membrane phospholipid breakdown metabolism in the vmPFC brain area of ABD with NSSI may be related to the severity of depression. The level of phosphoinositol cycle in the vmPFC brain area of ABD without NSSI may be related to age or onset age. Therefore, further validation was required.
Reproducibility and concordance of functional autonomy tests in older adult women: a comparative study of face-to-face and virtual assessments
Authors: Siqueira Talles M. , Pitta Rafael M. , Machado Alexandre F. , Scartoni Fabiana R. , Rica Roberta L. , Pontes Junior Francisco Luciano , Bullo Valentina , Gobbo Stefano , Bergamin Marco , Bocalini Danilo S. 
Published: January 2025

IntroductionThe literature does not explore functional assessments carried out remotely and in older women in virtual environments.ObjectiveThis study analyzed the reproducibility and agreement in applying functional autonomy tests face to face (FF) and virtually (V).MethodsA single evaluator carried out two evaluations. The following tests were performed: walking 10 m, rising from the sitting position (RSP), rising from the ventral decubitus position (RVDP), and sitting and rising from a chair and walking around the house (SRCW).ResultsNo significant changes were identified between V and FF (p &gt; 0.05 for all). No significant changes were identified between tests considering FF and V conditions (p &gt; 0.05 for all). The highest value for the intraclass correlation coefficient was &lt;0.0001 for the SRCW (CL, r = 0.98 CI95%: 0.969–0.990 and ICC, r = 0.99 CI95%: 0.984–0.995), and the lowest was &lt;0.0001 for the RSP (CL, r = 0.91 CI95%: 0.853–0.954 and ICC, r = 0.95 CI95%: 0.921–0.976). Regarding agreement between tests, a variation was found between the lowest value of 0.07 ± 0.74 BIAS for the RVDP and the highest value of 0.32 ± 1.89 BIAS for the SRCW.ConclusionThe tests used in the present study showed good reproducibility and agreement in older people when carried out face to face and virtually.
In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass
Authors: Zirari Malak , Aouji Marouane , Baghdad Wissal , Er-rajy Mohammed , Imtara Hamada , Abujaber Feras , Elharrati Otmane , Noman Omar M. , Tarayrah Mahmoud , Hmouni Driss , Mejdoub Nouredine El 
Published: January 2025

IntroductionMorocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess the nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass.MethodsThe nutritional value of the twigs and cones was determined using the AOAC method, while mineral components were examined through ICP-OES. To search for phytochemicals in the methanolic extracts, a number of established techniques were applied, and evaluate their antioxidant activity, while the volatile content was determined using the GC-MS method. The acute oral toxicity test was carried out following the guidelines of OECD 423.Results and discussionProximate analysis revealed a variety of components in different parts, including moisture, ash, fiber, protein, carbohydrates, and fat. Cones and twigs were found to be rich in mineral elements, as well as phenols, flavonoids, tannins, and phytosterols. Chromatographic analysis identified linoleic acid as the main component in twig extract and 2-Bornanone as the primary constituent in cone extract. The methanolic extracts of A. marocana displayed strong antioxidant properties through notable DPPH scavenging activity, with no mortality observed in rats even at doses exceeding 1,000 mg.kg−1, indicating potential for medicinal, cosmetic, or dietary uses. A molecular docking study of the five main compounds of both plants showed that they aligned and interacted with the binding sites of selected proteins, demonstrating significant antioxidant activity.
Albuminocytologic Dissociation and the Impact of Age-Adjusted Cerebrospinal Fluid Protein Levels in Guillain–Barré Syndrome
Authors: Thatikonda Nithisha , Lerint Alexandru , Takle Chaitra , Fang Xiang , Patel Chilvana 
Published: January 2025

Background: This study examined the impact of age-adjusted cerebrospinal fluid (CSF) protein levels on clinical characteristics, disease severity, and outcomes in Guillain–Barré Syndrome (GBS) patients. Methods: This retrospective study included 71 GBS patients at UTMB Galveston. Albuminocytologic dissociation (ACD) was defined as CSF–total protein (CSF-TP) >0.45 g/L with a cell count of <50 cells/L. Patients were grouped using the conventional cutoff (>0.45 g/L) and age-adjusted upper limits (URLs) for CSF-TP levels, comparing clinical, CSF, and electrophysiological characteristics across groups. Results: The mean age was 50 years (SD = 14.5). The mean age of patients with a CSF-TP > 45 g/L was higher (53 vs. 39 years, p = 0.000), whereas no such difference was noted using age-dependent URLs. Using age-adjusted CSF-TP URLs reduced the sensitivity for detecting ACD by 20%. CSF-TP > age-adjusted URLs were associated with lower MRC sum scores (39 vs. 47.43, p = 0.000), higher ICU admission rates (34% vs. 20%, p = 0.003), and the need for second-line treatment (41% vs. 17%, p = 0.049), and the trends were not observed with the conventional cutoff of 0.45 g/L. CSF-TP was an independent predictor of lower MRC sum scores (p = 0.009, 95% CI −0.058, −0.009) and higher GBS disability scores (p = 0.015, 95% CI 0.000, 0.004). Conclusions: ACD is a common finding in GBS, but normal protein levels do not exclude the diagnosis. Using age-adjusted URLs might improve specificity but reduce sensitivity for ACD detection, potentially increasing false negatives. CSF-TP levels exceeding age-adjusted URLs were more strongly associated with greater disease severity and poorer outcomes compared to the conventional cutoff of 0.45 g/L.
The role of the Frankfurt Plane in treatment planning and prognosis for patients with unilateral temporomandibular joint ankylosis developed in early childhood
Authors: Zangieva O. T. , Epifanov S. A. , Krainykova L. A. , Topolnitsky O. Z. 
Published: January 2025

Relevance. The treatment of unilateral temporomandibular joint (TMJ) ankylosis remains a significant challenge. Children who develop unilateral ankylosis in early childhood frequently exhibit pronounced craniofacial asymmetry. Accordingly, assessing the extent of asymmetry between the left and right sides of the skull, the positional discrepancy of the auditory canals, and the inclination of the Frankfurt plane is crucial for planning future analyses and reconstructing the TMJ fossa during total joint replacement.Objective. To determine the difference in the Frankfurt plane inclination angle in patients with unilateral TMJ ankylosis that developed in early childhood.Materials and methods. The study included 38 patients (18 boys and 20 girls) aged 13 to 19 years with unilateral TMJ ankylosis diagnosed between the ages of 1 and 6. All patients underwent head computed tomography (CT), followed by cranial rotation analysis using specialized software to align with the natural head posture. Measurements of cephalometric landmarks Porion (Por) and Orbitale (Or) on both sides of the skull were performed, and the inclination of the Frankfurt plane was assessed using Jacobson 3D digital analysis tools.Results. CT analysis of 38 patients with unilateral TMJ ankylosis, diagnosed between the ages of 1 and 6, revealed a consistent pattern in the position of the auditory canal and adjacent structures. The Porion on the ankylosed side was, on average, 5.74 mm lower than on the contralateral side. Furthermore, the mean inclination angle of the Frankfurt plane on the ankylosed side exceeded the normal range, averaging 5.48°, while the angle on the contralateral side remained within normal limits (0–3°).Conclusion. The difference in Frankfurt plane inclination observed in 87% of patients with unilateral TMJ ankylosis developed in early childhood should be taken into account when planning treatment, designing total TMJ prostheses, and forecasting clinical outcomes for this patient population.
Perfil clínico da síndrome hipertensiva na gestação
Authors: Trabulsi Rhana Luiza , Trabulsi Raíssa Brito Montenegro Tavares , Brandão Alana Pereira Arruda , Leite Thalissa Fernanda Matos Viana , Moreira Ana Júlia Nobre Monteiro , Weba Adna Silva , Araújo Agnnes Luíza Camara Bílio de , Oliveira Ana Clara Coutinho de , Oliveira Klycia Emannuelle Guterres , Lages Gabriela da Rocha Leódido Lauande , Bayma Jamylle Cantanhêde da Silva , Bayma Filho Paulo de Tarso de Carvalho , Salomão João Pedro do Prado 
Published: January 2025

A síndrome hipertensiva gestacional (SHG) é um conjunto de condições clínicas caracterizadas por aumento da pressão arterial durante a gravidez, podendo afetar tanto a mãe quanto o feto. Ela é dividida em várias categorias, incluindo hipertensão gestacional, pré-eclâmpsia e eclâmpsia. A hipertensão gestacional se refere ao aumento da pressão arterial superior a 140/90 mmHg, sem a presença de proteinúria, e normalmente se manifesta após a 20ª semana de gestação. Já a pré-eclâmpsia é caracterizada pela combinação de hipertensão com proteinúria e pode progredir para a eclâmpsia, que é a forma mais grave, associada a convulsões. A fisiopatologia da síndrome hipertensiva gestacional é multifatorial, envolvendo uma combinação de fatores genéticos, imunológicos e ambientais. O tratamento da SHG visa controlar a pressão arterial e prevenir complicações. Além disso, a identificação precoce e o manejo adequado da hipertensão gestacional são cruciais para reduzir a morbidade materna e fetal. Dessa forma, este estudo configura-se como uma revisão integrativa realizada por meio do levantamento bibliográfico nos diretórios: Google Scholare Scientific Eletronic LibraryOn-line (SciELO), com uso dos descritores DeCs (Descritores em Saúde) e o Medical Subject Headings (MeSH), nos idiomas português e inglês, com os seguintes termos: “Gestatação”(gestation), “hipertensão” (hypertension), “tratamento” (treatment). Desta busca, foram encontrados 150 artigos, posteriormente submetidos aos critérios de seleção. A seleção resultou em 6 artigos que foram submetidos à análise seletiva, exploratória e interpretativa no contexto do presente estudo. A partir da revisão bibliográfica dos estudos analisados, conclui-se que, a síndrome hipertensiva gestacional continua a ser uma das principais causas de morbidade e mortalidade materna e perinatal em todo o mundo. Embora os avanços no diagnóstico e tratamento tenham melhorado os desfechos, a gestão da SHG requer monitoramento constante e estratégias individualizadas para minimizar as complicações. O controle rigoroso dos fatores de risco e a implementação de intervenções precoces são essenciais para reduzir os impactos desta condição.
Comparative analysis of phenolics, flavonoids, antioxidant, anti-inflammatory and antimecrobial potential of methanolic and aqueous extracts from bunium incrassatum tubers
Authors: Samira Bouhalit , Lilia Douaouya 
Published: January 2025

This study investigates the comparative biological activity and chemical composition of aqueous and hydromethanolic extracts of Bunium incrassatum tubers, a plant with traditional medicinal uses. Both extracts were evaluated for their antioxidant, anti-inflammatory and antimicrobial activities. Antioxidant activity was measured by DPPH scavenging assays. In vitro anti-inflammatory activity using bovine serum albumin technique. While the antimicrobial activity was investigated using the disc diffusion assay against four Gram-positive and Gram-negative bacteria and three fungi.
The total phenol and flavonoid content showed that the methanolic extract had a significantly higher total phenolic content (167.4±3. 53 μg GAE/mg E) and flavonoid content (36.27± 2.18 μg QE/mg E) of than aqueous extracts. The antioxidant activity revealed that methanolic extract of B. incrassatum demonstrated higher antioxidant activity (IC50=1.15 ± 0.02 mg/mL). In contrast, it is the aqueous extract that has shown the most important anti-inflammatory activities to those of standard (sodium diclofenac).The study of antimicrobial activity demonstrated that the extracts showed a modest antibacterial and antifungal activity. Both extracts showed antibacterial activity, but the methanolic extract exhibited a higher zone of inhibition, especially against Staphylococcus aureus and Pseudomonas aeruginosa. This comparative analysis provides insights into the effectiveness of different solvent-based extractions for harnessing the therapeutic properties of Bunium incrassatum.
The invasive indo-asiatic horntail snail ARIOPHANTIDAE Tanychlamys indica (Godwin-Austen, 1883) in Santa Catarina State/ SC, Brazil: general status of its knowledge seven (7) years after the first report of their discovery in the Brazilian territory and the earth’s American ecozones
Authors: Agudo-Padrón Aisur Ignacio 
Published: January 2025

Introduction: Seven (7) full years have passed since the initial report of its occurrence in the Neotropical continental territory of Brazil (discovered/ detected its introduction on “September 16, 2017” in the geopolitical state of Santa Catarina/ SC). Tanychlamys indica (Godwin-Auster, 1833), alien indo-Asiatic pulmonate terrestrial gastropod representative of the family Ariophantidae, is confirmed for the first time in the Americas and the Caribbean basin, presumably introduced unnoticed through the international trade of citrus fruit seedlings. Objective: Updated general rеᴠiеw of the geographical occurrence situation of this introduced species in the Santa Catarina State/ SC, the Brazilian territory and the Earth’s American Ecozones. Methodology: Extensive review of general available information (field encounters, reports obtained directly from collaborators, data contained in the "Taxonomic Catalog of the Brazilian Fauna - Mollusca", journalistic informations & records on the international citizen science platform "íNaturalist") up to December 2024. Results and Conclusions: Today, the regional known of the occurrence of this alien species is restricted to Brazil, the only country in South America where its presence has been reported/ confirmed, verified in the Federal District (D.F.) and seventeen (17) of its twenty-sixth (26) geopolitical states, present in their every one six (6) terrestrial epicontinental biogeographic domains/ biomes: Amazon, Caatinga, Cerrado, Atlantic Forest, Pampa or Southern Fields & Chaco-Pantanal. Additional information available about its recent presence in the rest of the Earth's American Ecozones (Neotropical & Nearctic territories) is also presented, obtained through so-called citizen science.
Востребованность специалистов в сфере проектного управленияна рынке труда
Authors: Прохорова М.П. , Лебедева Т.Е. 
Published: January 2025

в работе описаны преимущества проектного управления для современных компаний и обоснован рост потребности в специалистах в области проектного управления на рынке труда. Проанализированы запросы работодателей относительно требований к специалистам в области проектного управления, представлен анализ регионов, в которых количество вакансий в сфере управления проектами наиболее высоко. Сделаны выводы о тенденции увеличения спроса на специалистов в области проектного управления. Ключевые слова: проект, управление, рынок труда, вакансии, требования, работодатели.
the paper describes the advantages of project management for modern companies and substantiates the growing need for specialists in the field of project management in the labor market. Requests of employers regarding requirements for specialists in the field of project management are analyzed, an analysis of regions in which the number of vacancies in project management is highest is presented. Conclusions are drawn about the trend of increasing demand for specialists in the field of project management.
Оценка эффективности процесса управления в Республике Саха (Якутия) на примере строительной компании ООО ГК «Прометей»
Authors: Васильева Н.Е. 
Published: January 2025

Работа выполнена с целью повышения эффективности процесса управления в сфере строительства жилых зданий в Республике Саха (Якутия) на примере компании ООО ГК Прометей . По результатам проведенного исследования определена общая степень эффективности управления, эффективности использования трудовых ресурсов, а также сформулированы актуальные направления развития компании.
This article was written to improve the efficiency of the management process in the construction market in the Republic of Sakha (Yakutia) on the example of a construction company LTD Prometey. The article defines the general degree of management efficiency, the efficiency of the use of labor resources and formulates the actual directions of the companys development.
Реформирование налоговой системы Республики Узбекистан: выбор пути развития
Authors: Джураев А.М. 
Published: January 2025

В данной статье были рассмотрены направления реформирования налоговой системы Республики Узбекистан. Выявлены общие и отличительные черты налоговой системы Республики Узбекистан и Российской Федерации. Ключевые слова: трансформация, методология трансформации, трансформация налоговых систем, налоговая реформа, налоговая система, налоговое отношение, налогообложения, Федеральный налог, региональный налог, местный налог.
In this article, certain aspects of the tax systems of the Russian Federation and the Republic of Uzbekistan are analyzed and comparatively studied. Identified common features and features of the tax systems of the Russian Federation and the Republic of Uzbekistan.
Национальные аспекты развития регионов: проблемы и решения
Authors: Шакиев Ш.О. 
Published: January 2025

Статья посвящена процессам человеческого развития в Кыргызской Республике и адресована всем, кто заинтересован в будущем страны. Рассмотренные проблемы позволяют по-другому увидеть потенциальные возможности для изменения ситуации в стране и могут служить не только источником разнообразной информации, но и быть эффективным инструментом для анализа ситуации и принятия решения.
The article is devoted to the processes of human development in the Kyrgyz Republic and addressed to everybody, who is interested in the future of country. Examined issues allowed to see from another side potential possibilities for changing situation in the country and can serve not only resources of various information, and also to be an effective instrument for situation analyses and decision making.
Информационные технологии в оптимизации бизнес-процессов
Authors: Поддубная М.Н. , Кравченко Н.А. 
Published: January 2025

В данной работе описаны основы оптимизации бизнес-процессов посредством использования информационных технологий. Современный этап развития бизнеса требует иного подхода к его совершенствованию использованию самых последних научных достижений. Применение информационных технологий в бизнесе позволяет осуществить его оптимизацию и улучшить тем самым показатели компании во всех практически направлениях. Оптимизация бизнес-процессов позволяет выйти организации на новый уровень, который позволит увеличить ее прибыль и сократить расходы.
This paper describes the basics of optimizing business processes through the use of information technology. The modern stage of business development requires a different approach to its improvement using the latest scientific achievements. The use of information technology in business allows for its optimization and thus improve the performance of the company in almost all directions. Optimization of business processes allows the organization to reach a new level, which will increase its profits and reduce costs.
Современные цифровые деньги: преимущества и недостатки
Authors: Драгуцан В.В. , Попова Е.И. 
Published: January 2025

В данной статье рассматриваются криптовалюты, их достоинства и недостатки. Более подробно раскрыты преимущества и недостатки криптовалюты Биткоин, рассмотрены его правовое регулирование в разных странах.
This article discusses cryptocurrencies, their advantages and disadvantages. The advantages and disadvantages of the Bitcoin cryptocurrency are described in more detail, its legal regulation in different countries is examined.
Что такое Fab Lab и что в нем можно сделать
Authors: Проскурина А.Д. 
Published: January 2025

В данной статье были рассмотрены определение Fab Lab и предназначение данной программы. Подобрано оборудование, которое используют во всех сферах жизнедеятельности и определена аудитория данного направления.
This article examined the definition of Fab Lab and the purpose of this program. Selected equipment that is used in all areas of life and determined the audience of this area.