bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effects of Quercus salicina blume leaves aqueous extracts against cadmium-induced oxidative stress and cell cytotoxicity in HK-2 cells
Authors: Kim Yun Jeong , Lee Joo-Won , Om Ae-son 
Published: November 2023

Background: Quercus salicina Blume is an evergreen plant growing southern parts of Korea and Japan, and has been used for the treatment of dysentery, dermatitis, and hemorrhage from possible effects such as anti-inflammatory, anti-endemic and litholytic activities. We investigated the underlying mechanisms of Quercus salicina Blume leaf extracts (QS) protection against cadmium treatment utilizing human kidney origin HK-2 cells.Methods: To ascertain the functional constituents of the hot water-extracted QS, we conducted analyses to determine the total phenolic and flavonoid contents. Subsequently, the antioxidant activity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric ion reducing antioxidant power) methods. After treating HK-2 cells with QS and Cd, we confirmed the production of reactive oxygen species (ROS) and the expression of related proteins through western blotting. This investigation aimed to assess the antioxidant and anti-apoptotic effects of QS against cadmium-induced oxidative stress. Results: QS exhibited strong antioxidative potential, since the samples exhibited significantly high DPPH and FRAP values. Upon exposure of HK-2 cells to cadmium, inducing oxidative stress, the application of QS effectively reinstated cellular antioxidative functions, leading to an augmentation in cell viability. Notably, the presence of QS attenuated the heightened expression of oxidative marker enzymes induced by cadmium treatment, including SOD (superoxide dismutase) 1, catalase, Nrf-2, and Heme-oxygenase. The apparent disappearance of the apoptotic bodies indicates a potential apoptosis controlling effect of QS. Furthermore, the considerable increase in sub-G1 phase with the addition of cadmium was diminished under QS treatment indicating the ability of QS to reduce the degree of apoptosis related cell cycle phase. The apoptotic quenching effects of QS were accompanied by the downregulation of pro-apoptotic protein Bax and up-regulation of pro-apoptotic Bcl-2. The examination of cleaved caspase-9 and caspase-3 has provided evidence that the pronounced anti-apoptotic activities observed in cadmium-challenged HK-2 cells significantly diminished in the presence of QS. Conclusions: QS is a highly effective antioxidant and reduces cell cytotoxicity caused by cadmium through antioxidant functions and anti-apoptotic capabilities.Keywords: Quercus salicina Blume leave, cadmium, antioxidant, anti-apoptosis
Plant-Extract of Mimusops elengi leaves and Flower-Mediated ZnO Nanoparticles: Synthesis, Characterization, and Biomedical Applications
Authors: Bashir Iram , Gillani Syeda Shaista , Majeed Fouzia 
Published: November 2023

The current study aims to employ an ecologically sustainable method, utilizing a plant-based extract derived from Mimusops elengi as both a reducing and capping agent. Synthesis of zinc oxide nanoparticles (ZnO NPs) was done from aqueous leaves and flower extracts of Mimusops elengi. Different spectroscopic techniques were used to characterize these biosynthesized (ZnO NPs) zinc oxide nanoparticles like UV-visible, FTIR, XRD, SEM, and EDX techniques. UV-visible spectroscopy showed the absorption wavelength of ZnO NPs at 353nm (leaves extracts) and 365nm (flowers extracts). FTIR spectra showed the absorption frequency of different functional groups present in plant extract along with ZnO peak at 637cm-1 (leaves extracts) and 643cm-1 (flowers extracts). XRD results revealed the hexagonal structure and crystalline nature of biosynthesized ZnO NPs. The average grain size calculated for ZnO NPs of leaves and flower extracts was 10.37 and 15.52nm, respectively. SEM analysis showed a hexagonal shape. EDX confirmed the formation and purity of ZnO NPs by showing an abundant % of zinc and oxygen atoms. The significant bactericidal efficacy of biosynthesized ZnO NPs was found against pathogens Escherichia coli and Staphylococcus aureus. When compared to ZnO nanoparticles from flower extracts and biosynthesized ZnO nanoparticles from leaf extract exhibited substantial suppression. ZnO-NPs synthesized from leaves and flower extracts of Mimusops elengi can be subjugated for biomedical and ecologically sustainable applications.
Jeffrey Koperski, DIVINE ACTION, DETERMINISM, AND LAWS OF NATURE [Book review]
Authors: Rubio Daniel 
Published: November 2023

<p>Jeffrey Koperski offers a philosopher of science’s intervention in the debate over divine action, with the dual purpose of providing a scientifically-historically informed clarification of key concepts such as “determinism” and “law of nature,” as well as proposing and defending his “neoclassical” model of divine action. Koperski frames the debate as between three broad factions: interventionists, who believe not only in ongoing divine activity that sustains creation, but also special divine action that violates the laws of nature; nonviolationists, who believe not only in ongoing divine activity that sustains creation, but also special divine action if it does not violate the laws of nature; and noninterventionists, who believe only in ongoing divine activity that sustains creation, not special divine action. Each of these factions is painted as searching for a way between the Scylla of Deism and the Charybdis of Occasionalism. Koperski’s own view is a novel version of nonviolationism. </p>
Locking and Unlocking: The potentialities for intra-storying-activism in “this” baglady collective.
Authors: Albin-Clark Jo , Ovington Julie A , Isom Philippa , Platt Louise , Harding Lucy , Carley Faelan , Elwell Alice , Pilson Anna , Marshall Charlotte E. , Smith Sharon Louise 
Published: November 2023

In this article we disrupt extractivist and privileged individualised knowledge production by decentering the human ‘I’ to ‘we’ through storying. By entangling more-than-human bodies, ‘we’ is re-configured through a posthuman praxis of an iterative metamorphosing Baglady storying collective. Starting with the provocation of locking and unlocking, we story as a way to make sense of political and ethical affectivities that disrupt and interrupt everyday materialities and spatialities. From here, we speculate with movements of response-ability as “intra-activism” (Renold & Ringrose, 2017, 631). For us, storying puts in motion intra-action, speculation, calls to act, relationality and feminist community building that we frame as intra-storying-activism. Making and re-making stories with intra-storying-activism navigates non-hierarchical post-authorship to re-imagine, speculate-with and trouble the human from extractivist positions. By foregrounding relationality as a multiplying storying, we create playful, dynamic and generative spaces for knowledge making as a collective that both welcomes and provokes calls to act.
Analisis Perbandingan Biaya Dan Waktu Antara Bekisting Kayu Multiplek Dengan Bekisting Bondek Untuk Plat Lantai
Authors: Maskur Atep , Fuadi Irvanul , Sukmara Edi 
Published: November 2023

Bekisting merupakan cetakan sementara yang mempunyai peranan penting saat pengecoran beton agar hasil cetakan beton sesuai rencana. Perencanaan bekisting tentu tidak lepas dari peranan biaya dan waktu. Ada berbagai jenis bekisting yang biasa dipakai di lapangan, tetapi tidak semua orang mengetahui perbandingan harga antara jenis bekisting, adapun tujuan penelitian ini adalah untuk membandingkan biaya dan waktu antara bekisting kayu multiflek dengan bekisting bondek untuk plat lantai di Kabupaten Ciamis. Metode penelitian yang dipakai pada penelitian ini adalah studi komparatif, yaitu membandingkan harga satuan pekerjaan dengan memakai bahan yang berbeda dalam suatu pekerjaan yang sama yaitu pekerjaan bekisting plat lantai dan dak atap antara menggunakan material kayu multiflek dengan material besi galvanis (bondek) untuk kemudian dianalisis dan dicari nilai yang lebih ekonomis dan efisien.
Berdasarkan penelitian yang dilakukan anggaran biaya yang dibutuhkan untuk pekerjaan membuat bekisting pelat lantai menggunakan multiplek pada Renovasi Masjid Al-Badriyah sebesar Rp.116.467.904,00 dengan harga untuk 1 m² nya adalah Rp.371.390,00. Sedangkan untuk pekerjaan bekisting bondek sebesar Rp.96.494.197,33 dengan harga untuk 1 m² nya adalah Rp. 307.698,33. Berdasarkan perbandingan harga terdapat selisih sebesar Rp. 19.973.706,00, sehingga harga bekisting bondek di Kabupaten Ciamis lebih murah dibandingkan dengan bekisting multiplek. Waktu yang dibutuhkan untuk menyelesaikan pekerjaan pemasangan bekisting menggunakan multiplek yaitu 34 hari kerja, sedangkan waktu yang dibutuhkan untuk menyelesaikan pekerjaan pemasangan bekisting menggunakan bondek yaitu 9 hari kerja. Berdasarkan perbandingan waktu, pekerjaan bekisting pelat lantai menggunakan bondek di kabupaten Ciamis lebih cepat 25 hari dibandingkan dengan bekisting multiplek. Dari segi biaya bekisting bondek lebih efisien sekitar 17 % dibandingkan dengan bekisting multiplek. Dan dari segi waktu bekisting bondek lebih efisien sebesar 74 % dibandingkan dengan bekisting multiplek.
PENERAPAN SISTEM TENAGA SURYA UNTUK PENERANGAN DI KELURAHAN SUKAPADA, KECAMATAN, KECAMATAN CIBEUNYING KIDUL KOTA BANDUNG
Authors: Barnadi Yudi , Kurniaviev Ajeng , Suryana Ase , Periardiansyah Neris 
Published: November 2023

Kelurahan Sukapada yang merupakan bagian dari kecamatan Cibeunying Kidul penerangan jalan umum (PJU) nya masih minim khususnya di wilayah RT 03 RW 02. Kurangnya penerangan jalan ini dapat menyebabkan meningkatnya kriminalitas dan kecelakaan lalu lintas, membuat area tersebut sangat berisiko baik bagi pengemudi maupun pejalan kaki. Selain itu, lingkungan yang gelap dapat memotivasi seseorang untuk melakukan kejahatan. seperti pencurian dan perilaku asusila. Karena populasi pendatang yang cukup besar , kejahatan dapat dengan mudah terjadi di lingkungan tersebut. Dari uraian terssebut diatas pemasangan lampu penerangan jalan umum dengan memanfaatkan listrik tenaga surya menjadi solusi permasalahan. Energi matahari ini memungkinkan akses sepanjang hari, yang sangat menguntungkan untuk daerah tropis. Konsumsi energi matahari juga dapat mengurangi biaya pengeluaran. Kegiatan Pengabdian Kepada Masyarakat (PKM) ini dilakukan untuk mengatasi masalah lingkungan, dan Tim PKM dari jurusan teknik elektro Universitas Widyatama melakukan pemasangan lampu penerangan jalan umum tenaga surya untuk mengatasi masalah tersebut.
SISTEM INFORMASI PKK BERBASIS WEBSITE MENGGUNAKAN FRAMEWORK CODEIGNITER (STUDI KASUS: KAMPUNG PURWOEJO)
Authors: Setiawansyah Setiawansyah , Lestari Dinda Titian , Megawaty Dyah Ayu 
Published: November 2023

Penyelenggaraan PKK merupakan salah satu tugas pemerintah desa atau kelurahan. Setiap desa atau kelurahanÂ memiliki kelompok PKK yang mendukung pemerintah desa atau kelurahan dalam pengelolaan kependudukanÂ dan pembangunan wilayah. Salah satunya desa/kampungpurworejo kecamatan kota gajah kabupaten lampungÂ tengah. Kampung purworejo adalah desa yang memiliki peranan penting dalam memberdayakan wanita untukÂ berpartisipasi dalam pembangunan desa dengan organisasi PKK yang dicanangkan pemerintah.OrganisasiÂ PKK memiliki sebuahstruktur organisasi.PKK juga mempunyai sebuah kelompok kerja (POKJA) dan setiapÂ POKJA memegang peranan kegiatan yang berbeda.Selama kegiatan PKK saat ini rekap hasil kegiatanÂ dilakukan secara manual di buku sekretaris. Dengan berkembangnyasistem informasi, proses pencatatan danÂ pendokumentasian kegiatan PKK harus terekap secara rapi dan terorganisir.Untuk memberikan solusi makaÂ perlunya dikembangkanSistemInformasiberbasis website dibangun dengan menggunakan metode penelitianÂ waterfalldengan pendekatan menggunakan UML sepertiusecase, activitydiagram,class diagramdll. HasilÂ dari penelitian ini adalah sistem informasiPKKberbasis websiteyang mencakup keseluruhan kegiatan PKK,Â termasuk diantaranya pendataan anggota,penyajian informasidandokumentasi kegiatan setiapPOKJA yangÂ akan membantu para petugas dalam menjalankan tugasnya dengan baik.
Echocardiographic functional determinants of survival in heart failure with abnormal ejection fraction
Authors: Ciampi Quirino , Cortigiani Lauro , Gaibazzi Nicola , Rigo Fausto , Zagatina Angela , Wierzbowska-Drabik Karina , Kasprzak Jaroslaw D. , Djordjevic-Dikic Ana , Haberka Maciej , Barbieri Andrea , Bartolacelli Ylenia , Pepi Mauro , Carerj Scipione , Villari Bruno , Pellikka Patricia A. , Picano Eugenio 
Published: November 2023

Background and AimsPatients with heart failure (HF) with reduced left ventricular (LV) ejection fraction (EF) have a heterogeneous prognosis, and assessment of coronary physiology with coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) may complement established predictors based on wall motion and EF.Methods and resultsIn a prospective multicenter study design, we enrolled 1,408 HF patients (age 66 ± 12 years, 1,035 men), with EF &lt;50%, 743 (53%) with coronary artery disease, and 665 (47%) with normal coronary arteries. Recruitment (years 2004–2022) involved 8 accredited laboratories, with inter-observer variability &lt;10% for CFV measurement. Baseline CFV (abnormal value &gt;31 cm/s) was obtained by pulsed-wave Doppler in mid-distal LAD. CFVR (abnormal value ≤2.0) was assessed with exercise (n = 99), dobutamine (n = 100), and vasodilator stress (dipyridamole in 1,149, adenosine in 60). Inducible myocardial ischemia was identified with wall motion score index (WMSI) stress &gt; rest (cut-off Δ ≥ 0.12). LV contractile reserve (CR) was identified with WMSI stress &lt; rest (cutoff Δ ≥ 0.25). Test response ranged from score 0 (EF &gt; 30%, CFV ≥ 32 cm/s, CFVR &gt; 2.0, LVCR present, ischemia absent) to score 5 (all steps abnormal). All-cause death was the only endpoint. Results. During a median follow-up of 990 days, 253 patients died. Independent predictors of death were EF (HR: 0.956, 95% CI: 0.943–0.968, p &lt; 0.0001), CFV (HR: 2.407, 95% CI: 1.871–3.096, p &lt; 0.001), CFVR (HR: 3.908, 95% CI: 2.903–5.260, p &lt; 0.001), stress-induced ischemia (HR: 2.223, 95% CI: 1.642–3.009, p &lt; 0.001), and LVCR (HR: 0.524, 95% CI: 0.324–.647, p = 0.008). The annual mortality rate was lowest (1.2%) in patients with a score of 0 (n = 61) and highest (31.9%) in patients with a score of 5 (n = 15, p &lt; 0.001).ConclusionHigh resting CFV is associated with worse survival in ischemic and nonischemic HF with reduced EF. The value is independent and additive to resting EF, CFVR, LVCR, and inducible ischemia.
Effects of women with gestational diabetes mellitus related weight gain on pregnancy outcomes and its experiences in weight management programs: a mixed-methods systematic review
Authors: He Jing , Hu Kaili , Wang Binghua , Wang Hui 
Published: November 2023

IntroductionProper controlling gestational diabetes mellitus (GDM)-related gestational weight gain (GWG) during pregnancy can optimize pregnancy outcomes and improve postpartum glucose homeostasis. This study aimed to explore the existing intervention programs, the effects on pregnancy outcomes, and the experiences of weight management for GDM-related GWG in women with GDM.MethodsThis mixed-methods systematic review was retrieved from nine databases. The retrieval time was from the database construction to September 20, 2023, and all studies were published in English and Chinese. The included records used quantitative, qualitative, or mixed methods and reported original studies of weight-related intervention regimens, effects on pregnancy outcomes, and women’s experiences and perceptions. This review used a convergent segregated approach to synthesize and integrate research findings from Joanna Briggs Institute (JBI) mixed-methods systematic reviews.ResultsThere were 16 articles that met the inclusion criteria, and the articles came from seven different countries and included 23,997 women with GDM. The meta-analysis pooled outcomes for the incidence of weight gain exceeding the Institute of Medicine (IOM) recommendations after GDM diagnosis to delivery was 0.31% (95% CI 0.21-0.42). The effectiveness of GDM-related weight interventions in reducing weight gain after GDM diagnosis was supported by quantitative evidence. The GDM-related GWG below the IOM recommendations is a protective factor (OR=0.68, 95%CI 0.48-0.97) for large for gestational Age (LGA), and above the IOM recommendations is a risk factor (OR=1.62, 95%CI 1.15-2.27) for LGA. In addition, no significant statistical significance was found in the pooled outcomes of small for gestational age (SGA). Avoiding excessive weight gain helps to optimize neonatal birth weight, pregnancy outcomes, and maternal blood glucose levels. According to qualitative survey results, some women with GDM experienced weight stigma, and a positive relationship between healthcare providers and GDM women helped in weight management.ConclusionFollowing a diagnosis of GDM, weight management interventions positively affected GWG and pregnancy outcomes. In order to improve compliance and safety of weight management in women with GDM, criteria and interventions for weight gain associated with GDM need to be further explored and improved.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=404492, identifier CRD42023404492.
Immigration and C-sections incidence: Maternal care and perinatal outcomes in the context of the pandemic in Chile
Authors: Carroza Escobar María Begoña , Silva Nicole , Ortíz-Contreras Jovita , Villegas Rodrigo , Vargas Sergio L. , Núñez Claudio , Vergara Maldonado Luis Felipe , Villanueva Loreto Paola 
Published: November 2023

IntroductionImmigration has increased significantly in Chile. Despite that all pregnant women, regardless of nationality and immigration status, have the right to access to all healthcare services during pregnancy, childbirth, and postpartum, inequities in health care outcomes and health provision have been reported. During COVID-19 pandemic, these inequities are completely unknown.ObjectiveThe aim of this study was to compare the incidence of c-sections according to mother's migration status, as well as other maternal care and perinatal outcomes in women giving birth at San José Hospital in Santiago, Chile, during the COVID-19 pandemic.MethodsA retrospective cohort study was designed including 10,166 registered single births at the San José Hospital between March 2020 and August 2021. To compare between groups, statistical tests such as Chi-square and Fisher's exact were used. Log Binomial regression models were performed adjusted for potential confounding variables. To estimate the strength of association the relative risk was used.ResultsImmigrant mothers account for 48.1% of the registered births. Compared to non-immigrant women, immigrants exhibit a higher proportion of c-section, specifically, emergency c-section (28.64% vs. 21.10%; p-value &lt; 0.001) but a lower proportion of and having a preterm birth (8.24% vs. 13.45%; p &lt; 0.05), receiving personalized childbirth care (13.02% vs. 14.60%; p-value &lt; 0.05), companion during labor and childbirth (77.1% vs. 86.95%; p-value &lt; 0.001), And postpartum attachment to newborn (73% vs. 79.50%; p-value &lt; 0.001). The proportion of COVID exposure was not significant between groups, not the severity also. Haitians had a highest risk of undergoing emergency c-section (aRR = 1.61) and Venezuelans had a highest risk of elective c-section (aRR = 2.18) compared to non-immigrants.ConclusionThis study reports high rates of c-sections in the entire population, but in immigrant populations it is even higher. Additionally, it found gaps in maternal care and perinatal outcomes between immigrants and non-immigrants. More studies are needed to elucidate the possible causes of these differences and establish new regulations to protect the reproductive rights of the immigrant population.
The two-stage molecular scenery of SARS-CoV-2 infection with implications to disease severity: An in-silico quest
Authors: Potamias George , Gkoublia Polymnia , Kanterakis Alexandros 
Published: November 2023

IntroductionThe two-stage molecular profile of the progression of SARS-CoV-2 (SCOV2) infection is explored in terms of five key biological/clinical questions: (a) does SCOV2 exhibits a two-stage infection profile? (b) SARS-CoV-1 (SCOV1) vs. SCOV2: do they differ? (c) does and how SCOV2 differs from Influenza/INFL infection? (d) does low viral-load and (e) does COVID-19 early host response relate to the two-stage SCOV2 infection profile? We provide positive answers to the above questions by analyzing the time-series gene-expression profiles of preserved cell-lines infected with SCOV1/2 or, the gene-expression profiles of infected individuals with different viral-loads levels and different host-response phenotypes.MethodsOur analytical methodology follows an in-silico quest organized around an elaborate multi-step analysis pipeline including: (a) utilization of fifteen gene-expression datasets from NCBI’s gene expression omnibus/GEO repository; (b) thorough designation of SCOV1/2 and INFL progression stages and COVID-19 phenotypes; (c) identification of differentially expressed genes (DEGs) and enriched biological processes and pathways that contrast and differentiate between different infection stages and phenotypes; (d) employment of a graph-based clustering process for the induction of coherent groups of networked genes as the representative core molecular fingerprints that characterize the different SCOV2 progression stages and the different COVID-19 phenotypes. In addition, relying on a sensibly selected set of induced fingerprint genes and following a Machine Learning approach, we devised and assessed the performance of different classifier models for the differentiation of acute respiratory illness/ARI caused by SCOV2 or other infections (diagnostic classifiers), as well as for the prediction of COVID-19 disease severity (prognostic classifiers), with quite encouraging results.ResultsThe central finding of our experiments demonstrates the down-regulation of type-I interferon genes (IFN-1), interferon induced genes (ISGs) and fundamental innate immune and defense biological processes and molecular pathways during the early SCOV2 infection stages, with the inverse to hold during the later ones. It is highlighted that upregulation of these genes and pathways early after infection may prove beneficial in preventing subsequent uncontrolled hyperinflammatory and potentially lethal events.DiscussionThe basic aim of our study was to utilize in an intuitive, efficient and productive way the most relevant and state-of-the-art bioinformatics methods to reveal the core molecular mechanisms which govern the progression of SCOV2 infection and the different COVID-19 phenotypes.