bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial activities along a 20 million-year-old pristine oil reservoir
Authors: Voskuhl Lisa , Möhlen Hannah , Schlautmann Christian , Mohammadian Sadjad , Severmann Ann-Christin , Koch Johannes , Köhne John , Rykkelid Erling , Rinna Joachim , Meckenstock Rainer 
Published: October 2023

Studies on oil reservoir microbiology typically take samples from producing reservoirs and sample fluids that have been pumped to the surface. This comes with problems since producing oil reservoirs are affected by production processes leading to changes in environmental conditions and the natural microbiome. Hence, pumped samples do not display an unaltered picture of the spatial distribution and composition of the microorganisms in the reservoir.
We took 13 samples from a freshly drilled sediment core of a pristine, heavily biodegraded oil reservoir in the North Sea. Core samples originated from above, within, and below the reservoir.
16S rRNA gene amplicon sequencing of the microbiome revealed distinct differences between sediments and formation water, indicating that studies on microbiomes from formation water alone are not necessarily representative for the microbial processes in an oil reservoir. Fluorescence microscopy showed that microorganisms live in small microcolonies on the sediment surface. CT-scanning with image analysis visualized the water phase distribution inside the reservoir sediments and clearly indicated water-filled voids that might be habitable for microorganisms, enlarging the surface for potential biodegradation. Employing microcosm experiments and reverse isotope labelling, we were able to determine the first degradation rates measured from cores above, within, and below a reservoir ranging from no activity up to 1 mM CO2/(gsediment x year), Results indicate significant degradation potential from autochthonous microorganisms in the reservoir above the water-contact-zone.
Evading the general issues of produced oil samples for studying microbiomes results in a more realistic picture of an oil reservoir unaffected by production artefacts.
Derrière les écrans, la recherche du miroir ?
Authors: Cailliau Michel 
Published: October 2023

L’auteur propose l’hypothèse qu’il y aurait un rapport entre l’attrait, parfois addictif, pour les écrans des technologies de l’information et de la communication (T.I.C) et les failles ou impasses de l’intersubjectivité, telle qu’elle se joue au cours du « stade du miroir ». En effet, la question de l’image y est particulièrement sensible, comme vectrice de la qualité de présence de la mère (ou de l’entourage) et ainsi de la capacité « subjectivante » au cours des interactions de cette période précoce de la vie. Quelques exemples cliniques et quelques conséquences pour les pratiques thérapeutiques illustrent le propos.
Traitements psychanalytiques en ligne : une expérience personnelle
Authors: Oromí Irene 
Published: October 2023

La communication interpersonnelle établie via les réseaux informatiques est désormais une réalité globale. Et la relation thérapeutique ne peut ignorer un phénomène aussi important. Peut-on analyser le lien généré par la réalité virtuelle sous l’angle de la théorie et de la technique psychanalytiques ? Sur la base de mon expérience personnelle relative à des cas de traitements à distance, je souhaite partager avec vous ce nouveau défi. Les nouveaux systèmes d’interrelation avec les patients annoncent une expansion passionnante. En même temps, ils obligent les psychanalystes à avoir recours à de nouvelles formulations et conceptualisations théoriques, techniques et éthiques.
Martine chez la psychologue : au-delà des premiers entretiens, du bleu ciel au rouge
Authors: Van Bourgonie Marianne 
Published: October 2023

Quelques moments d’une vignette clinique nous révèlent comment dans la relation transféro-contretransférentielle de la scène analytique, des zones silencieuses de la psyché peuvent se métaphoriser et le corps devenir « parlant ».
Configurations psychiques et composition picturale
Authors: Matot Jean-Paul 
Published: October 2023

J’ai défini ailleurs (Matot, 2019, 2020) une configuration psychique comme une position du fonctionnement mental constituée par l’activation et l’interaction régulières d’un ensemble d’éléments lui conférant une certaine stabilité et permettant la symbolisation d’un registre plus ou moins large, mais toujours limité, d’expériences. Dans cette perspective, l’émergence d’une configuration psychique peut être envisagée par analogie avec la genèse d’un tableau, et les écrits théoriques de quelques grands maîtres modernes peuvent nous inspirer à cet égard. Les dessins d’un enfant en thérapie mis en perspective avec des œuvres de Basquiat illustreront ce propos. Notre itinéraire nous amène à schématiser un processus en trois temps – déprise de l’objet pour atteindre la sensation – mise en formes et en couleurs de quelque chose reflétant la complexité indicible de cette sensation – constitution d’un fond informe d’où émergera la configuration du tableau – qui rejoint en partie certaines théorisations psychanalytiques, dont deux me retiendront car elles permettent également de pointer l’endroit où – de mon point de vue – elles risquent de nous ramener vers des impasses théoriques : le concept d’originaire et des pictogrammes chez Piera Aulagnier ; et la théorisation par Anne Brun d’un « transfert de la sensorimotricité » à partir de sa réflexion sur la place du médium pictural dans le traitement des pathologies graves de la symbolisation.
Le Psychanalyste et le Poète
Authors: Dufour Jacques 
Published: October 2023

Y-a-t-il un invariant entre interprétation du Psychanalyste et vers du Poète alors que leur style, leur objet et leur contenu ne laissent augurer qu’une exclusion réciproque ? Cette question s’est posée à l’auteur à partir d’une citation de Keats reprise par Bion, réunis dans une corrélation fondatrice de vacuité ignorante. L’auteur en suivra les développements, mettant en parallèle la conceptualisation de l’interprétation du changement catastrophique décrit par Bion avec la figuration et l’incarnation du vers du poème Hypérion de Keats qui dépeint trois modalités d’effondrement. Il en viendra à concevoir l’exclusion réciproque de l’interprétation et du vers comme formes de leur fonction d’intelligible ou de sensible, mais où l’unité de fonds de la vie psychique exige la langue métissée de l’interprétation et la langue bigarrée du vers.
Le verbe infra-verbal
Authors: Meurrens Anouk 
Published: October 2023

À travers le récit d’un atelier d’écriture mené dans une institution psychiatrique avec des patients schizophrènes, l’auteur questionne le travail de création poétique en lien avec les processus primaires et le travail onirique du Moi inconscient. Une question centrale de l’article est : quelle place peuvent prendre les mots dans la symbolisation primaire, alors qu’ils sont en général le propre de la symbolisation secondaire ?
Vers une nouvelle classification des modèles d'évaluation et de prédiction de l'érosion hydrique
Authors: Fadil Aïcha , Wahidi Farid El 
Published: October 2023

Cette synthèse passe en revue différentes méthodes d'évaluation de l'érosion et du transport des matériaux. Largement explorées depuis plusieurs décennies, ces approches permettent de prédire les pertes de terre et d'estimer les risques associés à l'érosion hydrique. Cependant ces modèles diffèrent considérablement, tant pour les phénomènes étudiés, leur nature et leur complexité sur le terrain, que pour l'approche mise en œuvre, à travers la variété et la qualité des données utilisées, les échelles d'application spatiale et temporelle et les informations obtenues en sortie, leurs types et leurs incertitudes.Une tentative de classification des modèles d'évaluation de l'érosion hydrique (129 modèles considérés) est présentée à partir de leurs attributs géospatiaux les plus déterminants pour la modélisation de l'érosion hydrique. Ils ont été identifiés, explicités et regroupés en six catégories : empiriques, conceptuels, physiques, d'évaluation multicritère, statistiques et d'apprentissage automatique. Ce travail décrit ensuite les atouts et les limites de chaque catégorie pour documenter les processus intervenant dans la mobilisation des matériaux, le développement de l'érosion sous différentes formes (en nappe, en rigoles ou en ravines) et les transports solides.
Relationship between nurses knowledge level and workload about implementation of patient identification
Authors: Arsyawina Arsyawina , Hilda Hilda , Supriadi Supriadi , Prawita Widiastuti Hesti , Syaputri Annisa , Sapto Pramono Joko 
Published: October 2023

Patient safety incidents can originate from patient identification errors. From the preliminary study, it was found that there were 3 cases of patient identification errors in the year 2022. The objective of this research was to determine the relationship between nurses knowledge level and workload with patient identification implementation. This study employed a quantitative method with a cross-sectional research design. This research aims to analyze the relationship between variables where the independent variable and dependent variable are identified at one unit of time. In this case, to determine the relationship between the level of knowledge and workload of nurses with the implementation of patient identification. The sample consisted of 93 individuals distributed across the inpatient wards. The research sample was selected used random sampling. The knowledge level and workload of nurses were independent variables, while the implementation of patient identification was the dependent variable. Data collected was used of a level of knowledge, workload, and application of identification questionnaire. Data analyzed used were with Chi-square test. The obtained p-value for the relationship between nurses knowledge level and the implementation of patient identification is p=0.018 (p<0.05). Therefore, there is a significant relationship between nurses knowledge level and the implementation of patient identification. P-value for the relationship between nurses workload and the implementation of patient identification is p=0.564 (p>0.05). This explains that there is no significant relationship between nurses workload and the implementation of patient identification. There is a significant relationship between nurses knowledge level and the implementation of patient identification. The majority of nurses demonstrated a good implementation of patient identification. It is recommended for the hospital management to make efforts to improve nurses knowledge, especially in the area of patient safety.
Network Pharmacology and Molecular Docking Analysis of the Mechanisms of Combined Radix Bupleuri (Chai-Hu) and Radix Paeoniae Alba (Bai-Shao) Treatment in the Prevention and Treatment of Alzheimer’s Disease
Authors: Huang Zhao-Han , Fang Yuan , Yu Qi , Wang Tong 
Published: October 2023

Abstract

Objective:
Radix Bupleuri and Radix Paeoniae Alba are referred to as Chai-Hu and Bai-Shao, respectively, in Chinese. We used molecular docking and network pharmacological approaches to explore the active components of this Chinese herb combination which is commonly used for treating Alzheimer’s disease (AD), the Chai-Hu and Bai-Shao pair (CBP).

Materials and Methods:
The active compounds and action targets of Chai-Hu and Bai-Shao were identified in the Traditional Chinese Medicine Systems Pharmacology database, and the Therapeutic Target Database, DrugBank, GenCards, DisGeNET, and Online Mendelian Inheritance in Man databases were used to identify therapeutic targets in patients with AD. To identify a common target of CBP in the treatment of AD, we used the Metascape tool to perform Gene Ontology function enrichment and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. In addition, CBP-AD protein–protein interaction (PPI) and herb-component-target networks were created using Cytoscape 3.8.2. Molecular docking was verified using AutoDock tools.

Results
We identified 20 active compounds of CBP, 202 active targets, 1,323 disease targets, and 117 active compound disease intersection targets; the PPI network showed that the top eight key targets were AKT1, interleukin (IL) 6, JUN, MAPK1, tumor necrosis factor, TP53, vascular endothelial growth factor, and epidermal growth factor. These act mainly on the fluid shear stress, atherosclerosis, IL-17, hypoxia-inducible factor-1, and nonalcoholic fatty liver disease pathways, among others, which control immune inflammation, cell proliferation, and apoptosis. Based on molecular docking results, the active components of CBP bind well to its key targets.

Conclusion
Our results indicated that CBP was effective for treating AD by reducing the expression of inflammatory factors, promoting cell proliferation and differentiation, and preventing nerve cell death and anti-neuronal cell apoptosis.
Clinico-Epidemiological Profile of Patients with Chronic Kidney Diseases of Unknown Etiology: A Hospital-Based, Cross-Sectional Study from Central India
Authors: Galhotra Abhiruchi , Rathore Vinay , Pal Rahul , Nayak Saurabh , Ramasamy Senthilkumar , Patel Suprava , Joshi Parvati , Nagarkar Nitin M , Jha Vivekanand 
Published: October 2023

AbstractIntroduction:Chronic kidney disease (CKD) not associated with known risk factors, called CKD of unknown etiology (CKDu), has been reported from several geographically distinct regions across the world. This study reports the clinical and epidemiological profile of patients with CKDu from a new hotspot in central India.Methods:This cross-sectional study describes the sociodemographic, clinical, and laboratory profile of the patients diagnosed with CKDu visiting a tertiary care public hospital in the state of Chhattisgarh in central India between June 2019 and June 2021. CKDu was diagnosed as progressive CKD, minimal proteinuria, absence of hematuria, diabetes, severe hypertension, systemic illness, glomerulonephritis or other urinary tract diseases, and presence of symmetrically contracted kidneyon ultrasound.Results:A total of 166 (3.1%) out of 5365 patients with CKD were diagnosed with CKDu. The mean age was 53.6 ± 11.8 years. The patients were predominantly male (n= 113, 68.1%), belonged to rural areas (n= 147, 88.6%), and were engaged in farming (n= 105, 63.3%). The estimated glomerular filtration rate (eGFR) at presentation was 21.5 ± 15.1 ml/min/1.73m2. Forty-four (26.5%) had stage 3 CKD, 57 (34.3%) had stage4 CKD, and 65 (39.2%) had stage5 CKD. There was an over-representation of CKDu cases in patients with CKD from Gariyaband (36.0%) and Mahasamund (25%) districts of Chhattisgarh and Nuapada (35.0%) and Balangir (30.0%) districts of Odisha.Conclusion:The study suggests clustering of cases of CKDu in certain districts of Orissa and Chhattisgarh.
Mindfulness influences the psycho-social dimension of chronic pain: A randomized controlled clinical trial in Indian context
Authors: Pal Anirban , Mukhopadhyay Purnava , Biswas Rajasree , Bhattacharya Dipasri 
Published: October 2023

Background and Aims:
In India, the awareness about the psycho-social dimension of chronic pain is minimal among physicians and patients. The research with community-based group therapies (like mindfulness) to address the psycho-social aspects in chronic pain patients remains limited. The aim of this randomized controlled trial was to see the effects of mindfulness on pain intensity, pain catastrophizing, chronic pain acceptance, perceived stress, well-being, and mindfulness characteristics.

Materials and Methods:
In this two-site, parallel group, clinical trial, 170 patients attending pain outdoors of two government hospitals in West Bengal, India, were randomized to attend five weekly in-person mindfulness sessions (cases) or usual care sessions (controls) within the hospital premises. Pre-program and post-program data were collected and analyzed using statistical methods like repeated measures analysis of variance.

Results:
In participants of the mindfulness group, significant changes post session were noted in pain intensity [F(1,326) = 15.0122; P = 0.0001291], pain acceptance [F(1,326) = 4.5311; P = 0.03403], and perceived stress score [F(1,326) = 13.2788; P = 0.0003122] compared to pre-session. The changes in pain catastrophizing, World Health Organization well-being and Freiburg mindfulness inventory scores were non-specific.

Conclusion:
Mindfulness had a positive influence on pain intensity, pain acceptance, and perceived stress of Indian chronic pain patients. The effects on pain catastrophizing, mindfulness characteristics, and well-being (non-specific) were also encouraging. Further studies will be required to substantiate these results.
Can Smartphones with External Microphones Be Used in Place of Sound Level Meters?
Authors: Gill Harkomal , Kambo Amardeep 
Published: October 2023

Sound and noise are two sides of the same coin, around us during our daily lives. Excessive noise is listed as a public health concern and is one of the most common environmental and occupational exposures. Many municipalities in BC enacted Bylaws to regulate noise, which are enforced by Bylaw Officers and Environmental Health Officers (EHOs).
Noise complaints are addressed by conducting measurements with approved and standardized Commercial Sound Level Meters (SLMs). Smartphone technology has progressed rapidly in the past decade, including the use of external microphones. Studies have been conducted on their use, however, the effects of their use have yet to be fully assessed.
Evaluation of Flurbiprofen's anticonvulsant properties in pilocarpine-induced convulsions in mice
Authors: Albrefkani Naktal , Naser Ahmed 
Published: October 2023

Background: Flurbiprofen is a nonsteroidal anti-inflammatory drug, it has non-selective COX inhibition properties, some NSAIDS has an anticonvulsant effect and benefit as an analgesic in seizure patient.
Objective: we aimed to evaluate the possible anticonvulsant effect of flurbiprofen in mice.
Methods: We used 25 mature male mice for our study, the mice were divided into five groups, then to prevent peripheral cholinergic activation, mice in all groups were injected intraperitoneally with atropine sulphate (1 mg/kg) subcutaneously one hour after dosing. Seizures were induced ten minutes later with a 300 mg/kg i.p. injection of pilocarpine. After the pilocarpine injection, the animals were monitored for 1 hour. seizures severity was tested by the Racine scale.
Results: flurbiprofen at 0, 10, 20 and 40 mg/kg orally causes a significant decrease in the onset of convulsion and a considerable decrease in the duration of convulsion in comparison with the control group. Flurbiprofen at 20 and 40 mg/kg orally inhibited seizure scores in pilocarpine-treated mice in a dose-dependent manner. High-dose of flurbiprofen (40 mg/kg) significantly reduced seizure scores, similar to diazepam.
Conclusion: flurbiprofen has potential anticonvulsant properties in mice models, further study must be conducted to assess the primary mechanism of action.
Comparative Evaluation of Dashamula saindhavaa Sarpi as Nasya (nasal administration) versus Oral administration in the Management of Ardhavabhedaka (~Migraine): A Randomized Parallel Group Clinical Study
Authors: Sinha Gaurav , Patni Kalpana 
Published: October 2023

Ardhavabhedaka is described as one of the eleven types of Shiroroga (headache disorders) in all Ayurvedic classical texts. It is a disease in which there is acute pain in half of the head, laterals of the neck, temporal region, ear and eyes. Based on the similarity in etiology, pathology, symptoms and treatment principles Ardhavabhedaka can be very well connected with migraine. As per the International Headache Society (IHS), Migraine accounts for 16% of all primary headaches. As per WHO, Migraine prevalence and incidence of the attack suggest that migraine attacks around 3000 persons per million populations every day globally. Aim of Study: To compare the effect of Dashmula saindhavaa Sarpi Nasya and Oral in the Management of Ardhavabhedaka wsr to Migraine. Material and Methods: Total of 68 patients of age group 16 to 60 years of either sex were enrolled based on headache as the chief complaint. After screening via a Pre-diagnostic questionnaire (IHS), 24 patients were excluded and 44 patients recruited were randomly divided into two groups, group A received Dashmula saindhavaa Sarpi nasya, 6 drops in each nostril for 7 days, repeated after intervals of 1 week (four cycles) and Group B received Dashmula saindhava Sarpi orally 12 grams/day in two divided doses for 2 months. The assessment was done based on 4 point grading score of Clinical symptoms of Ardhavabhedaka (Migraine). Result: Overall effect of therapy shows that in Group A 05.00% had the complete cure, 50.00% of patients had marked improvement and 40.00% had moderate improvement whereas, in Group B, 05.88% had the complete cure, 35.29% of patients had marked improvement and 35.29% had moderate improvement. Both groups showed highly significant results (p = >0.001) in severity, duration, and frequency and various parameters of Ardhavabhedaka with more percentage improvement in Group A i.e., with Nasya therapy. Conclusion: Clinical assessment of Dashmula saindhava Sarpi nasya and as oral therapy on different parameters of Ardhavabhedaka showed that both are effective and safe.
Comparison of the two extraction methods of fruit pulp of Aragvadha (Cassia fistula Linn.) by HPTLC
Authors: Chaudhari Manojkumar , Chaudhari Yogita 
Published: October 2023

Background: The existence of significant bioactive compounds in herbs makes them pharmacologically treasured. Aragvadha (Cassia fistula Linn.), generally known as 'golden shower tree' is popular for its medicinal properties in Ayurveda. The fruit pulp of it owns medicinal values. Each plant has certain bioactive important compounds. For the extraction of different vital compounds, there is a need of specific method of extraction, which are known as ‘panchavidha kashaya kalpana’ (five varieties of extraction) in Ayurveda. These are - Svarasa (expressed juice), Kalka (paste), Kvatha (decoction), Hima (cold infusion) and Phanta (hot infusion). From centuries, Ayurvedic physicians are using extraction method, called as 'phanta' (hot infusion) for the fruit pulp of Aragvadha as a conventional technique; Ayurvedic scriptures also recommend the 'kvatha' (decoction) extraction process. To assess the superiority of these two extraction procedures, the present work used high-performance thin layer chromatography (HPTLC) analysis of Aragvadha (Cassia fistula Linn.) fruit pulp methanolic extract for phytochemical profiling. Results: The HPTLC analysis of Aragvadha (Cassia fistula Linn.) fruit pulp methanolic extract was carried out using winCATS Planar Chromatography Manager system, and the outcomes, which were obtained as chromatograms (scanned at the wavelength of 254 nm and 366 nm) representing multiple peaks. The plant's phytochemical profile of both samples were established, and tables indicating the total count of peaks with the height, area, percent area of peaks, and Rf values. Conclusion: The study revealed that the 'kadha' (decoction) of Aragvadha (Cassia fistula Linn.) fruit pulp methanolic extract contains a rich variety of phytochemicals as compare to 'phanta' (hot infusion) which might be accountable for its therapeutic value and thus justifies superiority of the 'kadha' (decoction) extraction method.