bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impurity Profiling and a Stability Indicating Advanced Liquid Chromatographic Method Development and Validation for the Estimation of Related Impurities of Anagrelide
Authors: Peddi Pavani , Prasada Rao P.T.S.R.K. , Pavan Kumar Chebolu Naga Sesha Sai , Usha Rani Nannapaneni , Tulasi S. Lakshmi 
Published: January 2024

A novel, streamlined and highly selective isocratic liquid chromatographic method has been developed for the quantification of impurities present in anagrelide. Exceptional resolution between anagrelide and its impurities was accomplished utilizing a Waters Nova Pack C18 column (250 mm × 4.6 mm, 4 µm), employing a phosphate buffer with a pH of 4.4 as mobile phase A and a blend of acetonitrile and methanol with buffer in a 30:40:30 v/v/v ratio as mobile phase B. The column oven was maintained at 35 ºC and the mobile phase flowed at a constant rate of 1.0 mL/min, while detection was set at 254 nm. Rigorous validation was conducted to assess accuracy, precision, specificity, linearity and sensitivity. Validation studies have unequivocally established the HPLC method’s precision, specificity, rapidity, reliability and reproducibility. Linearity was ascertained for both anagrelide and its impurities, exceeding an R2 value of 0.95. The limits of detection (LOD) and limit of quantitation (LOQ) were determined to be more than sufficient for precise estimation. This method was validated in accordance with the stringent ICH guidelines. The relative standard deviation (RSD) for intra- day and inter-day precision remained consistently below 5%. Percentage recovery demonstrated excellent agreement, affirming the simplicity, specificity, precision and enhanced accuracy of method for determining related substances in pharmaceutical substances and various anagrelide-containing dosage forms.
Synthesis, Antimicrobial Activity and Molecular Docking of Some Novel 2-Aryl-4H-[1,3]-thiazolo[4,5-b]indoles
Authors: Bhargavi Posinasetty  , Kumarachari Rajasekhar Komarla , Chitrapu Prashanti , Devineni Jyothirmayee , Dharmalingam Sudhahar , Naresh Babu Chilamakuru , Kumar Jayendra 
Published: January 2024

In present study, six novel 2-aryl-4H-[1,3]-thiazolo[4,5-b]indoles (4a-f) were synthesized by integrating thiazole and indole motifs through a three-component one-pot condensation involving isatin, ammonium thiocyanate and arylaldehydes. Structural confirmation was achieved using IR, 1H NMR and mass spectrometric techniques. Molecular targets, bioactivity scores, drug-likeness, anti- tuberculosis and antibacterial properties and toxicity were all predicted using various computational techniques. To calculate binding affinities to Mycobacterium tuberculosis enoyl-ACP reductase and Escherichia coli Topoisomerase IV, in vitro bioactivity studies were performed and Schrödinger docking simulations were performed. Anti-tubercular efficacy was evaluated using the MABA method, while antibacterial effectiveness against both Gram-positive and Gram-negative bacteria was assessed through the agar plate method. The results highlight the potential of these heterocyclic molecular hybrids, positioning them as promising candidates for further lead optimization in the development of more potent and safer pharmaceutical agents.
Ustekinumab as a Treatment for Ixekizumab-Associated New-Onset Crohn's Disease in a Patient with Psoriasis
Authors: Tan Justin Ryan L. , Alba Willy S. 
Published: January 2024

ABSTRACT
Interleukin-17 inhibitors are effective treatments for plaque psoriasis. However, these medications have been linked to the development of new-onset inflammatory bowel disease (IBD) and the worsening of existing IBD in some patients. This case report describes a patient with plaque psoriasis who developed new-onset Crohn's disease after treatment with ixekizumab, an interleukin-17A inhibitor. He was then transitioned to ustekinumab, which resulted in successful remission of both psoriasis and Crohn's disease. This case highlights the potential for ustekinumab to be an effective rescue treatment for psoriasis patients with new-onset IBD triggered by medications.
Kepemilikan keluarga sebagai determinan kinerja perusahaan dengan biaya keagenan sebagai moderasi
Authors: Saputra Bayu Swastika , Muazaroh Muazaroh , Suhartono Suhartono 
Published: January 2024

Family ownership still dominates the companies’ ownership structure in Indonesia. However, family ownership can also have a positive or negative impact on the company’s performance the previous studies related to the impact of family ownership on the company’s performance provides different results. The purpose of the study was to examine the family ownership as determinant of the company’s performance with agency cost as a moderating variable. It took the sample of 13 manufacturing companies in the industrial and consumption sectors listed on the Indonesia Stock Exchange for the 2017-2020 periods. They were taken using a purposive sampling method. The data were analyzed using multiple linear regressions. The results showed that family ownership has a positive effect on the company’s performance, which means the greater the percentage of family ownership, the better the company's performance. It also showed that agency cost did not moderate the effect of family ownership on company performance. It can be implied that family ownership has a strong motivation to supervise company management to improve company performance.
Menelisik kebutuhan nasabah melalui self-service technology pada era transformasi digital
Authors: Sari Desak Made Febri Purnama , Ari Gede Yona Krisna , Martini Ida Ayu Oka , Parasari Nyoman Sri Manik 
Published: January 2024

Tujuan penelitian ini untuk mengetahui faktor yang paling memengaruhi Self-Service Technology terhadap kebutuhan nasabah. Teori yang digunakan adalah Techonology Acceptance Model (TAM). Adapun populasi yang dipilih pada penelitian ini yaitu nasabah mobile banking di BPR Kabupaten Gianyar Provinsi Bali, dengan jumlah sampel 115 nasabah yang ditentukan dengan teknik purposive sampling. Teknik pengumpulan data menggunakan kuesioner kemudian databya dianalisis menggunakan Uji Measure of Sampling Adequency dengan program Statistical Program for Social Science (SPSS) versi 25. Hasil temuan yang diperoleh yaitu dari tujuh variable dengan dua puluh tiga indikator faktor variabel yang dianalisis, hanya terbentuk lima faktor. Temuan hasil penelitian ini adalah terbentuknya dua faktor baru yang dinamakan faktor reputasi dan faktor user friendly . Dalam hal ini, faktor repuasi PT. BPR Sukawati Pancakanti mampu dengan cepat melayani nasabah dan ketika terjadi kendala custoumer service (CS) langsung menanganinya. Pada faktor user friendly PT. BPR Sukwati Pancakanti memberikan banyak kemudahan, di antaranya Bahasa yang mudah di mengerti dan fitur yang mudah digunakan semua kalangan usia. Penelitian ini berimplikasi yang menyarankan PT. BPR Sukawati Pancakanti agar lebih mengembangkan fitur-fitur mobile banking dalam membangun kepercayaan, desain yang baik, dan kecepatan yang maksimal.
Designing A Camouflaged Pavilion in A Bird Park with Metaphor Technique through Section Plan
Authors: Lovendianto Jeremy , Awanda Ara , Pratama Aldimas Kurniawan , Fahmi Rahma Luthfiyya , Muchlis Nurfahmi 
Published: January 2024

Metaphor technique adapting organic shape from nature requires advanced technology for its development. Metaphor with regular irregularity concepts provides better camouflage and harmony within context. Irregularity on bird’s nest metaphor is shown better in section plan. Conceptual thinking by section integrating various parameters requires dominant understanding toward structural context. Design context is a pavilion at Nansha Bird Park, Guangzhou, China. The presence of the pavilion should not interfere bird's habitat. Design purpose is making a pavilion that camouflage with minimum interruption toward site. Design approach applies metaphor technique. Metaphor utilizes natural shape (biomimicry) of bird’s nest as nest for humans and birds. By cutting the pavilion into half, the structural complexity of bamboo construction can be shown clearly. Form finding process is done by digital technology and parametric design to achieve optimal form from desired metaphor. Site contextuality is responded specifically by the utilization of bamboo material and construction. Structural system utilizes interwoven bamboo layers to shape monocoque structure with vector-active system. Exploration is done by Rhino 5 and Grasshopper application. Form exploration focuses on bamboo layers as pavilion's structure. Patterns by Grasshopper’s script are applied to each layer. The pavilion’s shape is derived from basic spherical shapes as a metaphor of bird's nest. The resulting shape is stretched to create more space and split in half to expose its structure. Pavilion design responds to site and climate by considering the relationship of function, material, and bamboo construction parameters. Limitation on parametric concepts makes optimization simulation problems have to be adjusted with constructability.
The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor–CaMKII pathway
Authors: Wang Jiafang , Feng Yankun , Qi Zhong , Li Jin , Chen Zhijun , Zhang Jinming , Zhu Degang 
Published: January 2024

Abstract
Remifentanil-induced hyperalgesia (RIH) is a common clinical phenomenon that limits the use of opioids in pain management. Esketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has been shown to prevent and treat RIH. However, the underlying effect mechanism of esketamine on RIH remains unclear. This study aimed to investigate the role and mechanism of esketamine in preventing and treating RIH based on the NMDA receptor–CaMKIIα pathway. In this study, an experimental animal model was used to determine the therapeutic effect of esketamine on pain elimination. Moreover, the mRNA transcription and protein expression levels of CaMKII and GluN2B were investigated to offer evidence of the protective capability of esketamine in ameliorating RIH. The results demonstrated that esketamine attenuated RIH by inhibiting CaMKII phosphorylation and downstream signaling pathways mediated by the NMDA receptor. Furthermore, ketamine reversed the upregulation of spinal CaMKII induced by remifentanil. These findings suggest that the NMDA receptor–CaMKII pathway plays a critical role in the development of RIH, and ketamine’s effect on this pathway may provide a new therapeutic approach for the prevention and treatment of RIH.
Zwischen organisierter Wachsamkeit und Chaos. Massenveranstaltungen, ephemere Räume und Herstellung von Sicherheit im 18. Jahrhundert
Authors: Weber Maria 
Published: January 2024

Zusammenfassung
Frühneuzeitliche Massenveranstaltungen wie Herrschereinzüge, Geburtstage und Hochzeiten wurden gezielt als Herrschaftsinstrument eingesetzt, um Status und Prestige, Vormachtstellung und Macht demonstrieren zu können. Während diese Aspekte bereits vielfach Gegenstand der historischen Forschung waren, zielt der vorliegende Beitrag darauf ab, Organisationsstrukturen hinter diesen Spektakeln herauszuarbeiten und konkret danach zu fragen, wie bei diesen spezifischen Ereignissen, bei denen der existierende Raum angeeignet und umgestaltet wurde, Sicherheit hergestellt werden konnte. Anhand der Analyse von Ordnungen und Zeitungsberichten aus dem 18. Jahrhundert (England, Frankreich) wird dabei zweierlei deutlich: Feierlichkeiten wurden erstens als Gefahren- und Bedrohungspotenziale für den urbanen Raum, Mensch und Eigentum wahrgenommen und charakterisiert. Zweitens zeigt der Beitrag, welche Maßnahmen und Mechanismen entwickelt wurden, um die latent vorhandenen Gefahren diskursiv zu antizipieren und praktisch verhindern oder abmildern zu können. Letztlich legt der Beitrag einen Vorschlag vor, Settings- und Konstellationsanalysen als epistemologische Prinzipien neu zu denken.
Mindful awareness and resilience skills for adolescents (MARS-A): a mixed-methods study of a mindfulness-based intervention for a heterogeneous adolescent clinical population
Authors: Vo Dzung X. , Tabi Katarina , Bhullar Manreet , Johnson Andrea , Locke Jake , Wang Sophia , Stewart S. Evelyn , Marshall Sheila K. 
Published: January 2024

Abstract

Objectives
Mindful Awareness and Resilience Skills for Adolescents (MARS-A) is a mindfulness-based intervention adapted for the adolescent population. While previous studies have explored the benefits of MARS-A in various single-diagnosis populations, the aim of this study was to assess MARS-A for a heterogenous clinical adolescent population with mental health and/or chronic diagnoses, focusing on the underlying suffering present in all these conditions rather than its effects on a single diagnosis itself.

Methods
Qualitative data was collected through interviews to understand post-intervention participant perspectives and experiences. Quantitative data was collected through measures to investigate preliminary secondary outcomes.

Results
After participating in MARS-A, participants reported qualitative benefits in enhanced well-being, including coping with difficult emotions and managing sleep and/or pain. Quantitative results showed a reduction in functional disability, psychological distress, perceived stress, and depressive symptoms; increase in positive affect; and benefit in coping with pain and chronic conditions.

Conclusions
MARS-A shows great potential in a heterogeneous clinical adolescent population.
Enhancing willingness to communicate in English among Chinese students in the UK: the impact of MALL with Duolingo and HelloTalk
Authors: Zhao Dan , Jablonkai Reka R. , Sandoval-Hernandez Andres 
Published: January 2024

Abstract
Over the past decade, mobile-assisted language learning technologies, such as smartphone applications, have become increasingly prominent in language learning; however, empirical research on how the use of mobile apps can influence students’ willingness to communicate (WTC) is scarce. This study assessed two mobile apps with distinct language learning approaches: Duolingo, grounded in grammar-translation and behaviourist principles, and HelloTalk, based on social constructivist theory and communicative language learning. The research examined the impact of these apps on Chinese students’ WTC in the UK. A mixed-methods approach, including a quasi-experimental design, was adopted, involving 67 International Foundation Year Chinese students from a Confucius Heritage Culture background. The participants were randomly assigned to two experimental groups (Duolingo, N = 33; HelloTalk, N = 34) and used one app for five weeks. Quantitative data were collected through pre- and post-treatment using a WTC scale and an English media usage frequency questionnaire. Qualitative data were obtained through semi-structured interviews. Results indicated that both apps enhanced WTC, with Duolingo exhibiting a slightly stronger effect. Participants displayed greater WTC with emotionally and socially connected individuals, while WTC with strangers remained lowest. Factors such as usage time, communication goals, and frequency of use influenced participants’ WTC with various groups of people.
Adequate cefazolin therapy for critically ill patients: can we predict active concentrations from given protein-binding data?
Authors: Böhle Tony , Georgi Ulrike , Hughes Dewi Fôn , Hauser Oliver , Stamminger Gudrun , Pohlers Dirk 
Published: January 2024

Abstract

Objectives
Therapeutic drug monitoring of β-lactam antibiotics has become an important tool for treatment of severe infections, especially for critically ill patients who often exhibit altered PK/PD. Therapeutic targets are based on MIC, which refers to the active concentration of the drug. Cefazolin, a β-lactam agent used for treating of MSSA bacteraemia, has a protein binding of approximately 80 %. Therefore, a reliable determination of the active, non-protein-bound concentration is required to ensure optimal therapeutic outcome.

Methods
From seven critically ill patients who received an initial dose of 2 g cefazolin, followed by a continuous 24 h infusion, a total of 24 serum samples were obtained. The non-protein-bound concentration was directly measured after ultrafiltration and compared to prediction based total concentrations and protein binding values from the literature. For the analysis, a rapid and reliable LC-MS3 based assay was established, offering maximum sensitivity and specificity.

Results
The measured non-protein-bound concentration varied over a wide range (7.6–118 mg/L), with 22 out of 24 samples exhibiting cefazolin levels above the therapeutic target values (8–16 mg/L). Additionally, the observed protein binding ranged from 29 to 78 % (median 66.8 %), which was significantly lower than that reported in the literature. When comparing the measurements to the predictive performance of total concentrations and protein binding values, poor results were obtained.

Conclusions
The results show a high variability in plasma protein binding of cefazolin in critically ill patients. Therefore, the “one-dose-fits-all” principle can no longer be considered up to date. For personalised cefazolin therapy based on therapeutic drug monitoring (TDM) it is recommended to determine the active, non-protein-bound drug concentration, as calculations from the total fraction yield poor results.
The Clash of Generations: Driving Forces Behind Charitable Giving Among Older and Younger Muslims
Authors: Siddiqui Shariq , Hughes Micah , Cheema Jehanzeb Rashid 
Published: January 2024

Abstract
In this exploratory, survey-based study (n = 606), we examined whether Muslim perceptions about giving have changed due to the increased government scrutiny of charitable donations. We also examined age-based differences in preferences for cash versus non-cash donations, sending cash abroad versus giving within the U.S., and the likelihood of Muslims donating to causes that benefit non-Muslims. Our empirical models controlled for demographic differences such as gender, marital status, income, education, race etc. Our statistical results suggest that in the U.S. (1) some Muslims feel that charitable giving to Muslim causes has decreased as a result of monitoring of such giving by the government; (2) older Muslims tend to prefer documented means of giving as opposed to cash donations; (3) Muslims who prefer to donate in cash within the U.S. tend to be similar in age to those who prefer to send money abroad; and (4) age has no bearing on U.S. Muslims’ likelihood of donating Zakat to causes that benefit non-Muslims. Implications are discussed.
Analyzing the Tripartite Relationship Among Public Debt, Economic Growth, and Political Risks: A Panel VAR Approach
Authors: Ben Hamouda Abderrazek 
Published: January 2024

Abstract
This study examines the triangular relationship between public debt, economic growth, and political risks, shedding light on the complex underlying dynamics of these factors. Using a Panel Vector Autoregressive (PVAR) model, we analyze this relationship from multiple angles across 117 countries. The study considers the impact of different political regimes and income levels, recognizing the importance of diverse economic and political contexts in shaping these interactions. The results reveal varied responses to public debt based on the political regime, highlighting that authoritarian systems, imperfect democracies, and full democracies exhibit distinct reactions. Additionally, the study underscores the influence of income levels on the relationship between public debt and economic growth. A balanced and comprehensive approach to public debt management is recommended, with an emphasis on political stability, transparency in political institutions, and economic diversification. Policymakers are advised to consider the duration of shocks to promote sustainable economic growth and fiscal health.
Heat transfer distribution of single oblique jet impingement in crossflow under different inlet conditions
Authors: He Juan , Deng Qinghua , Xiao Kun , Feng Zhenping 
Published: January 2024

Abstract
To further reveal the interaction between crossflow and jet, single oblique jet impingement in crossflow is studied. The influences of Reynolds number (Re = 3750–15,000), oblique angle (θ = 50°–90°), jet intake mode (jet normal to inlet plane and jet along hole axis), crossflow ratio (CR = 0.1–0.3) and temperature ratio (TR = 1.0–1.2) are considered. For both jet intake modes, with the decrease of θ, the peak value of Nusselt number increases and its location shifts upstream. The Nusselt number for case of jet normal to inlet plane is higher than that of jet along hole axis with wider lateral coverage range. The CR affects the convection heat transfer between crossflow and target surface, and it also affects the interaction between crossflow and jet. Synthetically, the best heat transfer appears at CR = 0.2. The Nusselt number decreases sharply when TR goes from 1.0 to 1.1, while the decline trend slows down when TR goes from 1.1 to 1.2.
Multidisciplinary sensitivity analysis for turbine blade considering thickness uncertainties
Authors: Yang Fan , Zhang Chunyu , Gao Wenjing , Li Lei 
Published: January 2024

Abstract
This work presents an approach for sensitivity analysis of turbine cooling blade with surface thickness uncertainties, combining mesh deformation method, neural network model and multidisciplinary analysis. Normally, for even tiny shape changes, conventional geometry-based method failed easily during the auto-processing analysis. Therefore, mesh deformation method was utilized to capture the tiny size changes in the multidisciplinary analysis for both the fluid and the structure meshes. The neural network model is constructed by design of experiments to reduce the computational cost. Sensitivity analysis of the multidisciplinary system of blade is performed by numerical difference algorithm with the neural network model. Results showed that the proposed method was effective and practical in engineering.
Concept of introverted space: is multidimensional, extroverted space an illusion?
Authors: Steinbach Ingo 
Published: January 2024

Abstract
The quantum-phase-field concept of matter is revisited with special emphasis on the introverted view of space. Extroverted space surrounds physical objects, while introverted space lies in between physical objects. Space between objects leads to a network structure of matter: a network in which one-dimensional spaces connect individual particles.
Data Interactive Control System Based on Heterogeneous Database of Information Fusion and Internet of Things
Authors: Han Jianying 
Published: January 2024

Abstract
To improve the data interaction control effect of a heterogeneous database and reduce packet loss rate and response time, a new heterogeneous database data interaction control system based on information fusion is designed. The system consists of hardware and software parts. The hardware part of the heterogeneous database data interaction control system is composed of a data extraction module, data sending and receiving module, encryption module, and data interaction control module. On the basis of completing hardware design, the system software is designed, a fuzzy similarity matrix is constructed by calculating the similarity among the evidence, the weight coefficient of each piece of evidence is calculated by calculating the support function of each piece of evidence, the evidence source model is modified by using discount rules, and Dempster–Shafer combination rules are transformed into matrix analysis. Combined with the modified evidence source model, information fusion of the heterogeneous database is carried out to complete the software design of the data interactive control system. The experimental results show that the data interaction control effect of the heterogeneous database in this system is good, and the packet loss rate and response time are low, improving the data interaction control effect.