bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can uric acid affect the immune microenvironment in bladder cancer? A single‐center multi‐omics study
Authors: Chen Haotian , Shi Donghui , Guo Changfeng , Zhang Wentao , Guo Yadong , Yang Fuhan , Wang Ruiliang , Zhang Junfeng , Fang Zujun , Yan Yang , Mao Shiyu , Yao Xudong 
Published: November 2023

AbstractMetabolic abnormalities are one of the important factors in bladder cancer (BCa) progression and microenvironmental disturbance. As an important product of purine metabolism, uric acid's (UA) role in BCa metabolism and immunotherapy remains unclear. In this study, we conducted a retrospective analysis of a cohort comprising 39 BCa patients treated with PD‐1 and 169 patients who underwent radical cystectomy at Shanghai Tenth People's Hospital. Kaplan–Meier curves and Cox regression analysis showed that the prognosis of patients with high UA is worse (p = 0.007), and high UA is an independent risk factor for cancer specific survival in patients with BCa (p = 0.025). We established a hyperuricemia mouse model with BCa subcutaneous xenografts in vivo. The results revealed that the subcutaneous tumors of hyperuricemia mice had a greater weight and volume in comparison with the control group. Through flow cytometric analysis, the proportion of CD8+ and CD4+ T cells in these subcutaneous tumors was seen to decline significantly. We also evaluated the relationship of UA and BCa by muti‐omic analysis. UA related genes were significantly increased in the CD8+ T cell of non‐responders to immunotherapy by single‐cell sequencing. An 11‐gene UA related signature was constructed and the risk score negatively correlated with various immune cells and immune checkpoints. Finally, a nomogram was established using a UA related signature to forecast the survival rate of patients with BCa. Collectively, this study demonstrated that UA was an independent prognostic biomarker for BCa and was associated with worse immunotherapy response.
The manufacturer's quality‐improvement decisions and evolutionary stable strategy of retailers' marketing objectives under network externality
Authors: Sun Linyang , Yi Yuyin , Yang Haishen , Li Huayi 
Published: November 2023

AbstractTo analyze the influence of network externality (NE) and bargaining power of retailers on the quality‐improvement decisions of the manufacturer, evolutionary stable strategy (ESS) of retailers' marketing objectives, and profits of retailers and the manufacturer, we developed an evolutionary game model of supply chain composed of a monopoly manufacturer and one population of retailers under NE. We found that the retailers' ESS is influenced by both NE and product quality‐improvement levels. With the improvement of NE or product quality‐improvement levels, the marketing objectives of retailers will experience three evolutionary stable states: profit maximization, coexistence of profit maximization and revenue maximization, and revenue maximization. The product quality‐improvement levels and retailers' profits do not necessarily improve with the increase of NE, which depend on the retailers' ESS, but the manufacturer's profits always benefit from NE. When retailers' bargaining power reaches a certain level, it can influence the ESS of retailers' marketing objectives. Interestingly, the retailers' bargaining power does not necessarily enhance their own profits; it is related to the ESS of retailers' marketing objectives but consistently reduces the manufacturer's profits.
Joint AAPM Task Group 282/EFOMP Working Group Report: Breast dosimetry for standard and contrast‐enhanced mammography and breast tomosynthesis
Authors: Sechopoulos Ioannis , Dance David R. , Boone John M. , Bosmans Hilde T. , Caballo Marco , Diaz Oliver , van Engen Ruben , Fedon Christian , Glick Stephen J. , Hernandez Andrew M. , Hill Melissa L. , Hulme Katie W. , Longo Renata , Rabin Carolina , Sanderink Wendelien B. G. , Seibert J. Anthony 
Published: November 2023

AbstractCurrently, there are multiple breast dosimetry estimation methods for mammography and its variants in use throughout the world. This fact alone introduces uncertainty, since it is often impossible to distinguish which model is internally used by a specific imaging system. In addition, all current models are hampered by various limitations, in terms of overly simplified models of the breast and its composition, as well as simplistic models of the imaging system. Many of these simplifications were necessary, for the most part, due to the need to limit the computational cost of obtaining the required dose conversion coefficients decades ago, when these models were first implemented.With the advancements in computational power, and to address most of the known limitations of previous breast dosimetry methods, a new breast dosimetry method, based on new breast models, has been developed, implemented, and tested. This model, developed jointly by the American Association of Physicists in Medicine and the European Federation for Organizations of Medical Physics, is applicable to standard mammography, digital breast tomosynthesis, and their contrast‐enhanced variants. In addition, it includes models of the breast in both the cranio‐caudal and the medio‐lateral oblique views. Special emphasis was placed on the breast and system models used being based on evidence, either by analysis of large sets of patient data or by performing measurements on imaging devices from a range of manufacturers.Due to the vast number of dose conversion coefficients resulting from the developed model, and the relative complexity of the calculations needed to apply it, a software program has been made available for download or online use, free of charge, to apply the developed breast dosimetry method. The program is available for download or it can be used directly online. A separate User's Guide is provided with the software.
Bioarchaeological insights into the Late Helladic communities of South Kynouria, Peloponnese: The case of the LH IIIA2‐IIIB2 burial cluster of Socha
Authors: Tritsaroli Paraskevi , Grigorakakis Grigoris , Richards Michael 
Published: November 2023

AbstractThis paper examines the human osteological remains unearthed from six Late Helladic (LH IIIA2‐IIIB2) (1390/70–1200/1190 BCE) tombs at Socha in the Peloponnese. It seeks to investigate the character of a Mycenaean community that though organically integrated into and highly dependent on the palatial system, manifested Mycenaean burial practices with a distinctly local character, namely, through the use of built cist‐tombs. Our analysis investigates further the identity of this community and explores whether these people had also adopted a different way of life, diet and mortuary behavior toward specific groups. The results show that the demographic composition, diet, and health characteristics of the deceased of Socha were analogous to most Mycenaean sites: (a) equal representation of males and females, (b) burial exclusion of infants and young children, and (c) homogenous C3 terrestrial diet. In addition, a tendency for a more frequent inclusion of middle‐aged females with subadults in the same tomb suggests gender and age differentiation are in play. On the other hand, even though the burials of Socha practiced collectivity, an emphasis on individuality through a less variable post‐mortem manipulation of the deceased is also in evidence and is characterized by single secondary deposits within the original grave, no evidence for commingling, and no evidence for removal nor selection of bones in secondary deposits. These characteristics demonstrate the differentiation of the group of Socha during a period of intensive movement and the creation of new settlements in South Kynouria.
Outcomes following proton therapy for pediatric esthesioneuroblastoma
Authors: Drescher Nicolette R. , Indelicato Daniel J. , Dagan Roi , Bradley Julie A. , Holtzman Adam L. , Mailhot Vega Raymond B. , Aldana Philipp R. , Sandler Eric S. , Morris Christopher G. , Mendenhall William M. 
Published: November 2023

AbstractBackgroundPediatric esthesioneuroblastoma (EN) can infiltrate skull base anatomy, presenting challenges due to high radiation doses and pediatric tissue sensitivity. This study reports outcomes of pediatric EN treated with proton radiotherapy (PT).ProcedureUsing an IRB‐approved prospective outcomes registry, we evaluated patient, tumor, and treatment‐related variables impacting disease control and toxicity in pediatric nonmetastatic EN treated with modern multimodality therapy, including PT.ResultsFifteen consecutive patients (median age 16) comprising Kadish stage B (n = 2), C (n = 9), and D (n = 4) tumors were assessed, including six with intracranial involvement, four with cranial nerve deficits, and four with cervical lymphadenopathy. Before radiation, two had subtotal and 13 had gross total resections (endoscopic or craniofacial). Two underwent neck dissection. Eleven received chemotherapy before radiation (n = 5), concurrent with radiation (n = 4), or both (n = 2). Median total radiation dose (primary site) was 66 Gy/CGE for gross disease and 54 Gy/CGE (cobalt Gray equivalent) for microscopic disease. Median follow‐up was 4.8 years. No patients were lost to follow‐up. Five‐year disease‐free and overall survival rates were 86% (no local or regional recurrences). Two patients developed vertebral metastases and died. Two required a temporary feeding tube for oral mucositis/dysphagia. Late toxicities included symptomatic retinopathy, major reconstructive surgery, cataracts, chronic otitis media, chronic keratoconjunctivitis, hypothyroidism, and in‐field basal cell skin cancer.ConclusionsA multimodality approach for pediatric EN results in excellent local control. Despite the moderate‐dose PT, serious radiation toxicity was observed; further dose and target volume reductions may benefit select patients. Longer follow‐up and comparative data from modern photon series are necessary to fully characterize any relative PT advantage.
Evaluation of tribological properties of silane‐treated rapeseed straw fiber reinforced friction polymer composites prepared by wet granulation
Authors: Zhang Qifeng , Qi Zicheng , Ma Yunhai , Yao Yumei , Li Lekai , Cong Xu , Zhang Cuiying 
Published: November 2023

AbstractReinforcing fibers play a key role in improving the tribological properties of friction polymer composites. Cellulose reinforcing fibers were extracted from rapeseed straw waste and prepared as friction composites based on wet granulation, and the effects of heat and rapeseed straw fiber (RSF) additions on the tribological properties were systematically investigated. The addition of RSF induced an important transformation of the major wear mechanism to abrasive wear, especially at 9 wt%, where the abundant tribo‐films contributed to the stability of the friction coefficients (fade rate 6.8%, recovery rate 106.6%), resulting in a 37.5% increase in wear resistance compared to no addition. Furthermore, XRD, FTIR and SEM analyses showed that the silane‐ethanol solution modification contributed to the good performance of RSF.Highlights
Rapeseed straw fiber (RSF) and granulation technology for polymer composites.
Addition of RSF transforms adhesive and fatigue wear into abrasive wear.
Friction models are developed to clarify the wear mechanism transformation.
A 37.5% increase in wear resistance was achieved when RSF was added at 9 wt%.
Hybrid network formation of silicon carbide and expanded graphene nanoplatelets in epoxy resin for thermal management
Authors: Chenari Reza , Fasihi Mohammad 
Published: November 2023

AbstractThe current study discusses the incorporation of silicon carbide (SiC) and expanded graphene nanoplatelets (GNP) hybrid filler into epoxy resin to enhance its thermal conductivity, mechanical, and electrical insulation properties. The hybrid filler was incorporated into the epoxy resin by ultrasonic‐assisted blending solution process, and the thermal, electrical, and mechanical properties of the samples were assessed. The results displayed that both SiC and GNP fillers enhance the thermal conductivity of the epoxy resin. Addition of 15.3 wt% SiC/GNP filler (15/0.3) to pure epoxy increased the thermal conductivity coefficient by over 230%. The samples maintained the electrical insulation properties with electrical conductivity (EC) less than 10−9 S/m. Both fillers reduced the breakdown voltage of the samples. Furthermore, strong filler‐matrix adhesion resulted in a significant 414% improvement in Izod impact strength.Highlights
Combining SiC and GNP fillers affects the thermal and electrical properties of epoxy.
SiC and GNP synergistically improved the thermal diffusivity and conductivity of epoxy.
The prepared composites remained in the range of electrical insulation.
The impact strength of composites enhanced more than 400% compared to epoxy.
Modeling the matching stage of HDPE hot plate welding: A study using regression and support vector machine models
Authors: Novakovic Boris , Kashkoush Mohamed 
Published: November 2023

AbstractThis research studies the material displacement of high‐density polyethylene (HDPE) during the initial stage of the hot plate welding (HPW) process, called the Matching stage. Newly developed mathematical models simulate the relationship between the main process parameters (force, temperature, and time) and the size of the surface area. The collected data was used to develop four mathematical models for material displacement and time. Two models are machine learning based models (support vector machines). The other two models are regression models in the form of functions. In addition, this study provides a visual representation of HDPE melt displacement with the changes in temperature and pressure. The obtained results indicate that these models can be used for developing a parameter adjustment process or determining specifications for new production equipment. The potential applications of the developed models can be extended to industries that use HPW of HDPE, such as automotive or aerospace. This could result in significant savings in the amount of scrap and waste due to inaccurate and ad hoc settings that currently take place in the industry.Highlights
Study of HDPE material displacement in the hot plate welding Matching stage.
Visualization of HDPE melt displacement with temperature and pressure changes.
Development of SVM and mathematical regression models.
Applications in parameter adjustment and equipment specification.
Savings in scrap and waste by reducing inaccurate settings.
Solar cell efficiency tables (Version 63)
Authors: Green Martin A. , Dunlop Ewan D. , Yoshita Masahiro , Kopidakis Nikos , Bothe Karsten , Siefer Gerald , Hao Xiaojing 
Published: November 2023

AbstractConsolidated tables showing an extensive listing of the highest independently confirmed efficiencies for solar cells and modules are presented. Guidelines for inclusion of results into these tables are outlined and new entries since July 2023 are reviewed.
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate
Authors: van Houwelingen Anneke , ter Heegde Freija , Boschloo Wendy , Piek Leonie , Wubbels Theo 
Published: November 2023

AbstractWe designed an escape room based on the basic principles of pharmacokinetics for undergraduate bachelor students and explored its effect on students' perceived motivational climate and usefulness as a formative assessment via a mixed‐method design. The effect on students' perceptions of the motivational climate was measured using pre‐ and post‐test measurements of the MUSIC® inventory. Students' experiences with the escape room and suggestions for improvement were collected by open‐ended survey questions. Forty‐one students initially joined the study while 28 students completed both the pre‐ and post‐test MUSIC® inventory. Data from the MUSIC® inventory revealed the effect of playing the escape room on students' situational interest was positive with medium to large effect (Cohen's dav = 0.63). Data from the open‐ended questions confirmed the outcome of the MUSIC® inventory. While there was a positive effect on situational interest, students found the escape room not very useful as a tool for formative assessment. Further research should include a control group and focus on the effect of the escape room on academic success and work toward increasing the capacity of the escape room for large‐scale courses.
The socioeconomic trajectories of New Zealand's diverse language communities: A longitudinal perspective
Authors: Buckingham Louisa 
Published: November 2023

AbstractThe extent of demographic diversity in some migrant‐receiving countries has led to the formation of majority‐minority (or superdiverse) cities, a phenomenon also found in New Zealand. Recognising that demographic diversity is dynamic, sensitive to mobility patterns and shifts in socioeconomic indicators, this study examines diversity through the lens of common (nonofficial) languages (n = 21), by employing customised census data spanning five consecutive census years (1996–2018) that provides insights into ethnicity, religion, education, employment, income, and residential density. Considerable variation was found in the identification with one or more religious and ethnic attributes; while some language speaker groups (LSGs) displayed a strong, stable identification, other cases were characterised by fluctuations and mobility. Similarly, considerable differences between LSGs were found with respect to education, employment and income, which can partially be explained by selective migration. Finally, residential density has increased in secondary cities, particularly among LSGs with more dynamic socioeconomic indicators. The analysis, informed by the different migration histories and settlement experiences of the LSGs, contributes to understanding the dynamic quality of diversity indicators and the relative socioeconomic im/mobility of some groups, and demonstrates how the concepts of superdiversity and hyper‐selectivity can be operationalised.
ConservationBots: Autonomous aerial robot for fast robust wildlife tracking in complex terrains
Authors: Chen Fei , Nguyen Hoa Van , Taggart David A. , Falkner Katrina , Rezatofighi S. Hamid , Ranasinghe Damith C. 
Published: November 2023

AbstractRadio tagging and tracking are fundamental to understanding the movements and habitats of wildlife in their natural environments. Today, the most widespread,widely applicabletechnology for gathering data relies on experienced scientists armed with handheld radio‐telemetry equipment to locate low‐power radio transmitters attached to wildlife from the ground. Although aerial robots can transform labor‐intensive conservation tasks, the realization of autonomous systems for tackling task complexities under real‐world conditions remains a challenge. We developedConservationBots—small aerial robots for tracking multiple, dynamic, radio‐tagged wildlife. The aerial robot achieves robust localization performance and fast task completion times—significant for energy‐limited aerial systems while avoiding close encounters with potential, counterproductive disturbances to wildlife. Our approach overcomes the technical and practical problems posed by combining a lightweight sensor with new concepts: (i) planning to determine both trajectory and measurement actions guided by an information‐theoretic objective, which allows the robot to strategically select near‐instantaneous range‐only measurements to achieve faster localization, and time‐consuming sensor rotation actions to acquire bearing measurements and achieve robust tracking performance; (ii) a bearing detector more robust to noise; and (iii) a tracking algorithm formulation robust to missed and false detections experienced in real‐world conditions. We conducted extensive studies: simulations built upon complex signal propagation over high‐resolution elevation data on diverse geographical terrains; field testing; studies with wombats (Lasiorhinus latifrons; nocturnal, vulnerable species dwelling in underground warrens) and tracking comparisons with a highly experienced biologist to validate the effectiveness of our aerial robot and demonstrate the significant advantages over the manual method.
Development of Meta‐Chemical Surface by Dip‐Pen Nanolithography for Precise Electrochemical Lead Sensing
Authors: Yadav Krishna K. , Shamir Dror , Kornweitz Haya , Peled Yael , Zohar Moshe , Burg Ariela 
Published: November 2023

AbstractDip‐pen nanolithography (DPN) is a powerful and unique technique for precisely depositing tiny nano‐spherical cap shapes (nanoclusters) onto a desired surface. In this study, a meta‐chemical surface (MCS; a pattern with advanced features) is developed by DPN and applied to electrochemical lead sensing, yielding a calibration curve in the ppb range. An ink mixture of PMMA and NTPH (which binds to Pb (II), as supported by DFT calculations) is patterned over a Pt surface. The average height of the nanoclusters is ≈13 nm with a high surface area‐to‐volume ratio, which depends on the ink composition and the MCS surface. This ratio affected the sensitivity of the MCS as a detecting tool. The results indicate that the sensor's features can be controlled by the ability to control the size of the nanoclusters, attributed to the unique properties of the DPN production method. These results are significant for the water‐source purification industry.
Homogenization based heating control for moist paperboard with evaporation on the pore surface
Authors: Orlik Julia , Khilkov Viacheslav , Rief Stefan , Andrä Heiko 
Published: November 2023

AbstractA control problem for the heating of moist paperboard with the evaporation of moisture from the inner pore surface is considered. The microstructure of the paperboard is known from the CT images. It is easily parametrized w.r.t. the volume fraction of the pores, the surface area of the pores related to the unit volume, averaged area of the contact surfaces between two fibers and the unsupported fiber length between two contact nodes, fiber thickness, and tortuosity. Simple averaging formulas are provided for the computation of the effective coefficients in the coupled diffusion‐heat problem and the dissipation energetic balance was analyzed and we pass to the limit w.r.t. the small parameter, the relation between the pore size and the paper‐board thickness. The limit model is similar to those models, recently available in the literature. However, it provides more understanding and different limiting models and the thresholds for them. Also, the limitation on the heating is derived from the solvability criteria, which means, that the evaporation should not overtake the heating. The model is validated by experimental and numerical results found in the literature.
Introduction: To Be More Relevant the Field of Science Education Needs to Be Less Relevant
Authors: Tolbert Sara , Bazzul Jesse 
Published: November 2023

AbstractIn this introductory chapter, we illustrate the importance of transdisciplinary and justice-oriented approaches to science education. We first challenge the rigid disciplinary boundaries of the fields of science and science education, and then lay out how Volume 2 of Reimagining Science Education in the Anthropocene offers creative diversions from the disciplining structures of ideologically conservative fields.