bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic layer-specific processing in the prefrontal cortex during working memory
Authors: Degutis Jonas Karolis , Chaimow Denis , Haenelt Daniel , Assem Moataz , Duncan John , Haynes John-Dylan , Weiskopf Nikolaus , Lorenz Romy 
Published: October 2023

AbstractThe dorsolateral prefrontal cortex (dlPFC) is reliably engaged in working memory (WM). Evidence from non-human primates indicates that the dlPFC comprises different cytoarchitectonic layers that play distinct roles in WM subprocesses; yet the functional role of the dlPFC’s laminar circuitry in human WM is not well understood. In this study, participants completed a delayed-match-to-sample WM task while undergoing functional magnetic resonance imaging (fMRI) at ultra-high resolution, which allowed us to examine layer-specific responses of the dlPFC to manipulations in WM load and motor response. We conducted univariate and multivariate analyses across all periods of the WM task: encoding, delay and retrieval. First, we observed that superficial layers activate stronger than deep layers to higher WM load during the delay period. This aligns with earlier work showing preferential superficial layer activation to WM manipulation and as such may indicate lamina-specific activation of the frontoparietal network to heightened task demands more generally. Second, we found that superficial layers show higher decoding of WM load differences than deep layers during the retrieval period. In this context, we could show that decoding of WM load in the superficial layer exhibited dynamic changes across the encoding, delay and retrieval period of the task, indicative of separate WM control processes that occur on the WM content. Last, we found that superficial and deep layers are both non-differentially involved in the motor response, contradicting earlier findings of a preferential deep layer activation in humans. Taken together, our results provide new insights into the functional laminar circuitry of the dlPFC during WM and provide further support for a dynamic account of dlPFC coding.
WOX11-mediated cell size control in Arabidopsis attenuates fecundity of endoparasitic cyst nematodes
Authors: Guarneri Nina , Willig Jaap-Jan , Willemsen Viola , Goverse Aska , Sterken Mark G. , Nibbering Pieter , Lozano-Torres Jose L. , Smant Geert 
Published: October 2023

SummaryCyst nematodes establish permanent feeding structures called syncytia inside host root vasculature, disrupting the flow of water and minerals. In response, plants form WOX11-mediated adventitious lateral roots at nematode infection sites. WOX11-adventitious lateral rooting modulates tolerance to nematode infections, however, whether this also benefits nematode parasitism remains unknown.Here, we report on bioassays using a35S::WOX11-SRDXtranscriptional repressor mutant to investigate whether WOX11-adventitious lateral rooting promotes syncytium development and thereby female fecundity. Moreover, we chemically inhibited cellulose biosynthesis to verify if WOX11 directly modulates cell wall plasticity in syncytia. Finally, we performed histochemical analyses to test if WOX11 mediates syncytial cell wall plasticity via reactive oxygen species (ROS).Repression of WOX11-mediated transcription specifically enhanced the radial expansion of syncytial elements, increasing both syncytium size and female offspring. The enhanced syncytial hypertrophy observed in the35S::WOX11-SRDXmutant could be phenocopied by chemical inhibition of cellulose biosynthesis and was associated with elevated levels of ROS at nematode infection sites.We therefore conclude that WOX11 restricts radial expansion of nematode feeding structures and female fecundity, likely by modulating ROS-mediated cell wall plasticity mechanisms. Remarkably, this novel role of WOX11 in plant cell size control is independent of WOX11-adventitious rooting underlying disease tolerance.
Sustainable building materials utilization in the construction sector and the implications on labour productivity
Authors: Adebowale Oluseyi Julius , Agumba Justus Ngala 
Published: October 2023

Purpose
The United Nations has demonstrated a commitment to preserving the ecosystem through its 2030 sustainable development goals agenda. One crucial objective of these goals is to promote a healthy ecosystem and discourage practices that harm it. Building materials production significantly contributes to the emissions of greenhouse gases. This poses a threat to the ecosystem and prompts a growing demand for sustainable building materials (SBMs). The purpose of this study is to investigate SBMs to determine their utilization in construction operations and the potential impact their application could have on construction productivity.

Design/methodology/approach
A systematic review of the existing literature in the field of SBMs was conducted for the study. The search strings used were “sustainable” AND (“building” OR “construction”) AND “materials” AND “productivity”. A total of 146 articles were obtained from the Scopus database and reviewed.

Findings
Bio-based, cementitious and phase change materials were the main categories of SBMs. Materials in these categories have the potential to substantially contribute to sustainability in the construction sector. However, challenges such as availability, cost, expertise, awareness, social acceptance and resistance to innovation must be addressed to promote the increased utilization of SBMs and enhance construction productivity.

Originality/value
Many studies have explored SBMs, but there is a dearth of studies that address productivity in the context of SBMs, which leaves a gap in understanding. This study addresses this gap by drawing on existing studies to determine the potential implications that using SBMs could have on construction productivity.
Spectrophotometry and chromatography analyses combined with chemometrics tools to differentiate green coffee beans into special or traditional
Authors: Claro Gomes Winston Pinheiro , Gonçalves Bortoleto Gisele , Melchert Wanessa R. 
Published: October 2023

AbstractGreen coffee is the hulled coffee bean, rich in chemical compounds indicative of quality before roasting, making the classification special or traditional. This work aimed to determine compounds in green coffee beans and find the differentiation of green coffee beans into special or traditional ones through chemometrics. For that, the levels of phenolic compounds, reducing, nonreducing, and total sugars were quantified by spectrophotometry: caffeine, trigonelline, 5‐hydroxymethylfurfural (5‐HMF), 3‐hydroxybenzoic, 4‐hydroxybenzoic, chlorogenic, caffeic, and nicotinic acids (NAs) by high‐performance liquid chromatography–UV–Vis; acetaldehyde, acetone, methanol, ethanol, and isoamyl by HS‐GC‐FID. Principal component analysis (PCA) was used to differentiate green coffee beans through the levels obtained in spectrophotometric and chromatographic analyses. Statistically, the contents of total phenolic compounds, caffeine, nonreducing sugars, total sugars, NA, 5‐HMF, acetaldehyde, ethanol, and ethanol/methanol showed significant differences. The PCA made it possible to classify green coffee beans into special and traditional, in addition to understanding the attributes that influenced the differentiation between coffees. In addition, it was possible to classify green coffee beans into special and traditional, either using all parameters evaluated or only using spectrophotometric analyses. In this way, some advantages allow classification without using a trained and experienced evaluator as their previous experience can influence the results due to their expertise in a certain type of coffee, in addition to being faster and cheaper, especially regarding spectrophotometric analyses.
Anti‐osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model
Authors: Yang Xin‐Yue , Wu Dan‐Dan , Zhuang Cong‐Cong , Ma Chao‐Mei 
Published: October 2023

AbstractSecoisolariciresinol diglucoside (SDG) and tracheloside (TCL) are the main lignan components of flaxseed cake and safflower seed cake, which are by‐products of oil extraction. Both SDG and TCL are metabolized into mammalian lignan enterolactone (EL) with the involvement of intestinal bacteria. In this research, we evaluated the anti‐osteoporosis effects of SDG and the in vivo metabolites EL and enterodiol (ED) prepared in our previous work, as well as the newly isolated chemical constituents from safflower seed, including TCL, the lactone ring opening product of TCL (OTCL) and two alkaloids on the alloxan‐induced zebrafish model. All the compounds showed significant anti‐osteoporosis effects at 80 µM, with p < 0.05 for EL and p < 0.001 for other compounds compared with the model. SDG and TCL showed the most significant and concentration‐dependent effects, with p < 0.001 compared with model at 20 µM. The alkaloids, N‐coumaroylserotonin glucoside and N‐feruloylserotonin glucoside, also showed anti‐osteoporosis at 20 µM with p < 0.01, whereas EL, ED, and OTCL showed no significant effects. Quantitative real‐time polymerase chain reaction revealed that SDG and TCL upregulated the expression of osteogenic genes Runx2, SP7, OPG, Col1a1a, Alp, ON, OPN, and OCN in alloxan‐treated zebrafish. The in vivo metabolite of lignans, EL, showed significant anti‐inflammatory effect (p < 0.01) at 20 µM, which might also help to combat osteoporosis and other complications caused by excessive immune response in the body. The results provided scientific data for using the oil extraction by‐products as sources of anti‐osteoporosis compounds.Practical ApplicationThis study found that lignans in flaxseed cake and safflower seed cake exhibited anti‐osteoporosis effects by upregulating the expression of osteogenic genes, making the oil extraction by‐products sources of anti‐osteoporosis compounds.
Testicular function after non‐cytotoxic and immunotherapy drug treatment
Authors: Handelsman David J. , Idan Amanda , Sleiman Sue , Bacha Fey , Long Georgina V. , Menzies Alexander M. , Vaishnav Tejnei , Litkouhi Noosha , Volckmar Xanthie , Ledger William , Anazodo Antoinette 
Published: October 2023

AbstractBackgroundThe effects of novel non‐cytotoxic and immunotherapy drugs for cancer treatment on human testicular function have not been studied systematically.ObjectivesThe present study aimed to characterize effects of non‐cytotoxic and immunotherapy drugs in patients with cancers who had not been previously treated with gonadotoxic chemo‐ or radiotherapy.Materials and methodsThis study involved 34 men, not previously treated with gonadotoxic regimens, in a mixed longitudinal (Cohort 1: 19 men about to start and approximately 1 year on non‐cytotoxic and immunotherapy treatment) and cross‐sectional (Cohort 2: 15 men already on non‐cytotoxic and immunotherapy treatment) study using data modeling to estimate within‐person time‐course changes in testicular exocrine and endocrine functions. Cohort 1 provided 45 paired semen and blood samples (34 prior to and nine during treatment) and Cohort 2 provided 45 sets of samples (15 pre‐treatment, 30 on treatment), including six men in Cohort 2 who had pre‐treatment spermatozoa cryostorage prior to the study. Men on non‐cytotoxic and immunotherapy treatment had undergone a median of 33.5 months long‐term treatment.ResultsSpermatozoa output and concentration were reduced by about 50%, with corresponding increases in serum follicle‐stimulating hormone and decreases in serum inhibin B. Serum testosterone, luteinizing hormone, and sex hormone‐binding globulin were unaffected by non‐cytotoxic and immunotherapy treatment.ConclusionWithin limits of the present study of sample size and duration of on‐non‐cytotoxic and immunotherapy treatment, non‐cytotoxic and immunotherapy drugs have a modest effects on testicular exocrine function (sperm production) or its hormonal correlates (follicle‐stimulating hormone, inhibin B), with minimal impact on testicular endocrine (testosterone, luteinizing hormone) function.
Use of the anterior prostatic urethral mucosa preservation technique during holmium laser enucleation of the prostate can reduce postoperative stress urinary incontinence
Authors: Fujisaki Yukiya , Otsuka Isamu , Kobayashi Takahiko , Miyake Nao , Ito Kaoru , Terada Naoki , Kamoto Toshiyuki , Iwamoto Hideyasu 
Published: October 2023

AbstractIntroductionHolmium laser enucleation of the prostate (HoLEP) is an effective and safe surgery for patients with benign prostatic hyperplasia. However, some patients exhibit postoperative urinary incontinence. Here, we compared surgical outcomes and incidence of stress urinary incontinence between HoLEP with and without anterior prostatic urethral mucosa preservation (APUMP).MethodsAll patients in this study underwent HoLEP with APUMP technique (APUMP group) and without APUMP technique (no‐APUMP group). Enucleation weight, enucleation time, max flow rate increase at 3 months, and urinary incontinence rates immediately after catheter removal and at 1 month after surgery were compared between the groups.ResultsIn the APUMP (n = 340) and no‐APUMP (n = 75) groups, the median enucleation weights were 34.5 and 35.0 g, respectively (p = .982). The corresponding median enucleation times were 33.0 and 46.5 min (p < .01), and median max flow rate increases at 1 month were 10.5 and 9.9 mL/s (p = .89). The urinary incontinence rates immediately after catheter removal were 4.1% and 14.7% (p < .01), and were 3.8% and 12.0% (p < .01) at 1 month after surgery.ConclusionHoLEP using the APUMP technique could be performed with a shorter operative time while maintaining efficacy. The incidence of postoperative urinary incontinence could be decreased by APUMP, indicating that such preservation facilitates the maintenance of urinary continence after surgery.
Sleep spindles as neurophysiological biomarkers of schizophrenia
Authors: Ferrarelli Fabio 
Published: October 2023

AbstractSchizophrenia (SCZ) is a complex psychiatric disorder characterized by a wide range of clinical symptoms, including disrupted sleep. In recent years, there has been growing interest in assessing alterations in sleep parameters in patients with SCZ. Sleep spindles are brief (0.5–2 s) bursts of 12‐ to 16‐Hz rhythmic electroencephalogram (EEG) oscillatory activity occurring during non‐rapid eye movement (NREM) sleep. Spindles have been implicated in several critical brain functions, including learning, memory and plasticity, and are thought to reflect the integrity of underlying thalamocortical circuits. This review aims to provide an overview of the current research investigating sleep spindles in SCZ. After briefly describing the neurophysiological features of sleep spindles, I will discuss alterations in spindle characteristics observed in SCZ, their associations with the clinical symptomatology of these patients and their putative underlying neuronal and molecular mechanisms. I will then discuss the utility of sleep spindle measures as predictors of treatment response and disease progression. Finally, I will highlight future directions for research in this emerging field, including the prospect of utilizing sleep spindles as neurophysiological biomarkers of SCZ.
Prevalence of pre‐eclampsia in 265 patients with an intracranial aneurysm, 393 female relatives versus a control cohort: A case–control study
Authors: Kotikoski Satu , Paavola Juho , Nurmonen Heidi J. , Kärkkäinen Virve , Huuskonen Terhi J. , Huttunen Jukka , Koivisto Timo , von und zu Fraunberg Mikael , Jääskeläinen Juha E. , Lindgren Antti E. 
Published: October 2023

AbstractBackground and objectivesThere is emerging evidence on the connection between pre‐eclampsia and saccular intracranial aneurysms (sIAs). Our aim was to study the prevalence of pre‐eclampsia in sIA patients, their female relatives, and matched controls, and to examine familial sIA disease and familial pre‐eclampsia in sIA patients' families.MethodsWe included all female sIA patients in the Kuopio Intracranial Aneurysm Patient and Family Database from 1995 to 2018. First, we identified the sIA patients, their female relatives, and matched population controls with the first birth in 1987 or later and studied the prevalence of pre‐eclampsia. Second, all female sIA patients and all female relatives were analyzed for familial sIA disease and familial pre‐eclampsia. Using the Finnish nationwide health registries, we obtained data on drug purchases, hospital diagnoses, and causes of death.ResultsIn total, 265 sIA patients, 57 daughters, 167 sisters, 169 nieces, and 546 matched controls had the first birth in 1987 or later. Among them, 29 (11%) sIA patients, 5 (9%) daughters, 10 (6%) sisters, 10 (6%) nieces, and 32 (6%) controls had pre‐eclampsia. Of all the 1895 female sIA patients and 12,141 female relatives, 68 sIA patients and 375 relatives had pre‐eclampsia, including 32 families with familial pre‐eclampsia.ConclusionsPre‐eclampsia was significantly more common in the sIA patients than in their matched controls. Familial sIA disease and familial pre‐eclampsia co‐occurred in seven families. Further studies of the mechanisms by which pre‐eclampsia could affect the walls of brain arteries and increase the rupture risk in sIA disease are indicated.
Assessing climatic and spatial variables influencing zooplankton richness for space‐for‐time predictions
Authors: Heuschele Jan , Andersen Tom , Walseng Bjørn , Hessen Dag O. 
Published: October 2023

Abstract

The macroecological drivers of freshwater diversity are accredited geographical, spatial and climatic variables, but also to productivity, ecosystem age and landscape history. Locally diversity is also influenced by the dispersal ability of species. Here we evaluated how spatial and climatic variables influence species richness and macroecological patterns in Cladocera and Copepoda. We also discuss whether a space‐for‐time approach is suitable to predict the community's response to the current rapid warming of lakes.

We use the presence‐absence of pelagic and littoral microcrustaceans in 1465 Norwegian lakes with a wide range of latitudinal, longitudinal, and altitudinal gradients, as well as a wide span in lake areas, to evaluate how spatial and climatic factors influence zooplankton diversity in two major groups: Cladocera and Copepoda.

Longitude and latitude per se were poor predictors of zooplankton richness, but a combination of spatial and ecological predictors gave a good spatial prediction of cladoceran and copepod richness. These two groups did, however, not differ in their spatial distribution, with a strikingly fixed proportion of copepods close to 0.3, suggesting no obvious Allee‐ effects regarding the mode of reproduction (asexual vs sexual).

Since temperature alone was a poor predictor of species richness for both groups and dispersal constraints can make it very difficult to estimate a new richness equilibrium under a future climate, space‐for‐time predictions may have limited value for assessing future patterns of microcrustacean diversity.

Based on a quite unique dataset in terms of the sheer number of sites, spatial gradients, and inclusion of littoral species, our study demonstrates that assessments on how changing climate will shape and modulate zooplankton communities in the future are problematic.
Farmers' adaptation and mitigation practices in the Upper Rhine Valley: Drivers, synergies and trade‐offs
Authors: Bohnert Gaël , Martin Brice 
Published: October 2023

AbstractThrough semi‐structured interviews, this work analyses the motives and drivers leading wine growers and crop farmers in the Upper Rhine Valley (France, Germany, Switzerland) to adopt climate change adaptation and mitigation practices. We show that the main motive is to adapt, seen from an individual and reactive point of view. However, these practices sometimes also bring negative side effects in the long term or on other actors, and considering other problematics. On the contrary, other farmers’ thinking is more anticipatory and they pay more attention to the common good. Nevertheless, they are not necessarily the most successful in adaptation in the short term as they often are more affected. This shows the limits of the concept of adaptation, as centred on individuals and eluding issues that are not related to climate change. That is why we prefer considering system transitions, taking into account the interactions between the diverse problematics and actors.
Sense of psychological ownership in co‐design processes: A case study
Authors: Juel Anette , Berring Lene L. , Erlangsen Annette , Larsen Erik R. , Buus Niels 
Published: October 2023

AbstractIntroductionService users are increasingly participating in health research. Although collaborative research is assumed to give users a sense of psychological ownership, little is known about the specific psychosocial processes through which ownership develops and is displayed. The present study yields insight into a process in which service users, researchers and a website designer collaborated to design a website.AimThe aim of this study was to explore how participants developed and displayed feelings of ownership during a collaborative process to design a website.MethodsA case study design was adopted by which audio recordings were subjected to thematic analysis and interpreted by drawing on the concept of psychological ownership.FindingsA sense of psychological ownership of the website design process emerged in two distinct and overlapping phases. In the first phase, ‘sense of ownership during the early design phase’, only researchers and the website designer displayed a sense of ownership, which was facilitated by the research context preceding the collaborative workshops. In the second phase, ‘sense of ownership during the collaborative design phase’, service users gradually started to develop parallel feelings of ownership that were facilitated by workshop design activities. These activities enabled service users to increasingly control the process, to invest themselves in the process and to gain intimate knowledge of the process and its outcome. Service users' sense of ownership was displayed in their statements about the website and its elements.ConclusionParticipants engaged in codesign processes may develop a sense of psychological ownership at different speeds because of contextual factors. It is important to take this into account as it may complicate the formation of egalitarian work groups.Patient and Public ContributionParents of children with suicidal behaviour and a counsellor participated as service users in a website design process.
Filtering low‐energy carriers to enhance thermoelectric performance of Cd‐doped SnSe via incorporation of MXene sheets
Authors: Qin Yi , Wang Mengxue , Li Xiaohan , Zhang Yajuan , Tang Shenglai , Zhu Jianfeng , Zhao Ting 
Published: October 2023

AbstractSnSe‐based materials have attracted widespread attention in thermoelectrics due to their outstanding thermoelectric performance. However, the pristine and unmodified polycrystalline SnSe reveals poor electrical properties. Doping and constructing nanostructured composite architectures to produce energy filtering effect proved to be an effective method to strengthen thermoelectric performance. In this study, Ti3C2/Sn0.98Cd0.02Se composites are successfully fabricated by the solvothermal method combined with the electrostatic self‐assembly method and spark plasma sintering. The phase interface introduced by incorporating Ti3C2 into Sn0.98Cd0.02Se can effectively filter low‐energy carriers due to its generation of energy barriers, thereby the Seebeck coefficient of x wt% Ti3C2/Sn0.98Cd0.02Se x = (0.05, 0.5, 1) samples is better than that of the pristine Sn0.98Cd0.02Se over the whole temperature range. Meanwhile, high conductivity was also obtained in 1 wt% Ti3C2/Sn0.98Cd0.02Se sample so that the high power factor of 3.31 μWcm−1K−2 was acquired at 773 K. Ultimately, a peak ZT value of 0.41 was obtained at 773 K, compared with pristine Sn0.98Cd0.02Se, and the thermoelectric performance improved by 24%. This study offers an available approach to efficiently enhance the thermoelectric properties of polycrystalline SnSe‐based materials.