bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharpness of some Hardy-type inequalities
Authors: Persson Lars-Erik , Samko Natasha , Tephnadze George 
Published: December 2023

AbstractThe current status concerning Hardy-type inequalities with sharp constants is presented and described in a unified convexity way. In particular, it is then natural to replace the Lebesgue measure dx with the Haar measure $dx/x$
d
x
/
x
. There are also derived some new two-sided Hardy-type inequalities for monotone functions, where not only the two constants are sharp but also the involved function spaces are (more) optimal. As applications, a number of both well-known and new Hardy-type inequalities are pointed out. And, in turn, these results are used to derive some new sharp information concerning sharpness in the relation between different quasi-norms in Lorentz spaces.
Association between dietary insulin index and load with cardiometabolic risk factors and risk of metabolic syndrome among the patients with type 2 diabetes: a cross-sectional study
Authors: Arabshahi Vajeheh , Amiri Roksaneh , Ghalishourani Samira Sadat , Hasaniani Nazila , Nozarian Shadi , Tavasolian Ronia , Khiabani Alireza , Rahimlou Mehran 
Published: December 2023

Abstract
Background
This study aims to investigate the association between dietary insulin index (DII) and load (DIL) with cardiometabolic risk factors and the risk of developing metabolic syndrome (MetS) among patients with type 2 diabetes (T2DM).

Methods
A cross-sectional study was conducted among 500 T2DM patients. Dietary intake was assessed using a validated food frequency questionnaire, and DII and DIL were calculated based on insulin response and energy content. Logistic regression analyses were performed to determine the odds ratios (ORs) for MetS.

Results
Participants in the highest quartile of DIL had significantly higher odds of MetS (OR: 2.16; 95% CI: 1.02–4.25, P = 0.039) and hyperglycemia (OR: 1.69; 95% CI: 1.08–4.96, P = 0.032). We also discovered that patients in the highest quartile of DII had higher odds of MetS (OR: 1.69; 95% CI: 1.08–4.96, P = 0.034) and hyperglycemia (OR: 1.39; 95% CI: 1.04–4.12, P = 0.019). Furthermore, participants in the highest quartile of DIL (OR: 1.64; 95% CI: 1.00-2.59, P = 0.03) and DII (OR: 1.42; 95% CI: 1.05–1.95, P = 0.026) had higher odds of high waist circumference. When it came to hypertriglyceridemia, we found a significant association between DII and DIL only in the crude model, not the fully adjusted model. However, we didn’t observe any significant association between DII and DIL with hypercholesteremia, Low HDL, and high blood pressure (P > 0.05).

Conclusion
Our study provides evidence suggesting that a higher DII and DIL may be associated with an increased risk of cardiometabolic risk factors and MetS in patients with T2DM.
Two cases of vitamin B12 deficiency in patients with beta-thalassemia trait: lessons in diagnosis
Authors: Chauhan Kriti , Shandilya Nikhil 
Published: December 2023

Abstract
Background
Coexisting pathologies is not a new phenomenon and can cause diagnostic difficulties when they overshadow one another. They may alter the cytomorphology of cells and the machine readings to an extent that the actual diagnosis is missed. One such scenario is created by coexisting megaloblastic anemia and beta-thalassemia trait where the RBC indices and the hemoglobin chromatogram findings conform to neither of the two.

Case presentation
We present two cases of anemia presenting with normocytic normochromic indices, increased red cell distribution width (RDW), elevated HbA2 levels and moderately high HbF levels in both of them and an additional low HbA1c in case 2. Upon evaluation of peripheral smear and biochemical tests, a non-immune hemolytic component was also identified with deficient Vit B12 levels in case 1 and highly elevated levels post-supplementation in case 2.

Conclusions
Taking together the peripheral smear, erythrogram, chromatogram and biochemical findings, it was deduced that the alterations were caused by coexisting beta-thalassemia trait and megaloblastic anemia. Vit B12 deficiency was the cause behind hemolysis owing to intramedullary destruction of abnormal precursors. Upon supplementation in case 2, the immediate reticulocyte response was the reason behind spuriously low HbA1c.
Centimeter-level-precision seafloor geodetic positioning model with self-structured empirical sound speed profile
Authors: Xue Shuqiang , Li Baojin , Xiao Zhen , Sun Yue , Li Jingsen 
Published: December 2023

AbstractIn-field Sound Speed Profile (SSP) measurement is still indispensable for achieving centimeter-level-precision Global Navigation Satellite System (GNSS)-Acoustic (GNSS-A) positioning in current state of the art. However, in-field SSP measurement on the one hand causes a huge cost and on the other hand prevents GNSS-A from global seafloor geodesy especially for real-time applications. We propose an Empirical Sound Speed Profile (ESSP) model with three unknown temperature parameters jointly estimated with the seafloor geodetic station coordinates, which is called the 1st-level optimization. Furthermore, regarding the sound speed variations of ESSP we propose a so-called 2nd-level optimization to achieve the centimeter-level-precision positioning for monitoring the seafloor tectonic movement. Long-term seafloor geodetic data analysis shows that, the proposed two-level optimization approach can achieve almost the same positioning result with that based on the in-field SSP. The influence of substituting the in-field SSP with ESSP on the horizontal coordinates is less than 3 mm, while that on the vertical coordinate is only 2–3 cm in the standard deviation sense.
Unusual presentation of systemic lupus erythematosus in a male child: a case presentation
Authors: Gupta Khyati , Sawant Vishal Dnyaneshwar , Save Sushma 
Published: December 2023

Abstract
Background
Systemic lupus erythematosus is an autoimmune connective tissue disorder that is common among women of age group 15–40 years. The novelty in our case is owed to the deceptive demographic characteristics, not only the sex (F >  > M) but also of the age profile (common in 15–44 years age group) along with deviation from typical disease presentation of skin rash/arthritis/nephritic syndrome. We aim to emphasize the importance of having a high index of suspicion in any child presenting with nephrotic range proteinuria in order to prevent delay in diagnosis.

Case presentation
Eight-year-old boy presented with generalized swelling, proteinuria, hypoalbuminemia and hypertriglyceridemia and was found to be unresponsive to systemic steroid therapy. Further testing revealed low complement levels(C3/C4) along with ANA positive, homogenous pattern (titre ≥ 1:80) and anti-dsDNA positive (titre 229:24) pointing towards the diagnosis of childhood SLE, which was made based on EULAR/ACR criteria. Subsequent renal biopsy was done in order to stage the disease and for initiation of appropriate treatment protocol.

Conclusions
SLE is a highly heterogenous disorder in terms of clinical presentation. All patients with steroid resistant nephrotic syndrome should undergo renal biopsy as a part of their workup. This case is a learning opportunity which demonstrates that even in absence of typical disease manifestations and demographic profile, a high index of suspicion will help in rapid diagnosis and prevention of complications. Knowledge about the varied presentations of renal lupus is of utmost importance for the same.
The effect of a structured running exercise intervention on non-exercise physical activity and sedentary behaviour in persons with mild Multiple Sclerosis and healthy controls
Authors: Nieste Ine , Spaas Jan , Franssen Wouter M. A. , Asch Paul V. , Savelberg Hans H. C. M. , Eijnde Bert O. 
Published: December 2023

Abstract
Background
Exercise interventions fail to increase objective physical activity (PA) in persons with Multiple Sclerosis (PwMS), while they self-report higher exercise participation. This suggests that PwMS change their non-exercise PA (NEPA). We aimed to explore NEPA changes of PwMS and healthy controls (HC), and whether these constrain exercise adaptations.

Methods
Twenty-nine mildly-disabled PwMS and 26 HC completed a 10-month home-based running program. A non-randomised controlled study design was used. The primary outcome was time in different NEPA intensities (light intensity PA [LIPA] and moderate-to-vigorous intensity PA [MVPA]) and in sedentary behaviour ([SB]; total and uninterrupted SB) at baseline (T1), after 5 (T2) and 10 (T3) months of exercise. Data were averaged over days with and without exercise sessions (EX and NONEX days). Secondary outcomes included patient-reported and physical exercise adaptations (fatigue, walking mobility, blood pressure, body composition and cardiorespiratory fitness).

Results
A significant reduction in non-exercise MVPA was observed from T1 to T2 (− 113 ± 31 min/week, p < 0.01) and from T1 to T3 (− 95 ± 26 min/week, p < 0.01) in PwMS, which approximately matched the weekly exercise duration at those time points. PwMS also increased their uninterrupted SB on NONEX days compared to EX days (+ 0.7 ± 0.3 h, p < 0.01). There were no changes in MVPA or SB of HC (group × time effect MVPA: p < 0.05; group × EX day effect uninterrupted SB: p < 0.01). Secondary outcomes improved similarly in both groups and were not associated with NEPA/SB changes.

Conclusions
In contrast to HC, PwMS significantly changed their NEPA and the pattern in which they accumulated SB in response to structured exercise. This might be a necessary behavioural compensation in order to adhere to the exercise intervention and did not constrain patient-reported and physical outcomes. Future research is warranted to unravel the underlying causes and to investigate the effects on other exercise adaptations, such as cardiometabolic health.
Trial registration The present study was registered (December 10, 2019) at clinicaltrials.gov as NCT04191772
Closing the patient-provider gap along the surgical journey one click at a time: results of a phase I pilot trial of a patient navigation tool
Authors: Shoucair Sami , Downing Gregory , O’Rourke Jacqueline , Greenberg Liza , Yea Mike , Vatas Gunjan , Kim Paula , Fishbein Thomas , Unger Keith , Winslow Emily 
Published: December 2023

Abstract
Background
Patients diagnosed with complex hepato-pancreaticobiliary (HPB) conditions experience a challenging journey through the healthcare system. Patient navigation is commonly offered to patients and their caregivers throughout this process. Here, we report on the development and phase I testing of a prototype web-based dual (patient and provider) navigation application ‘PatientNav.’

Methods
Evidence-based recommendations were determined through a needs assessment. The PatientNav app was designed to be a highly customizable tool based on the needs of the patients, the care team, and the characteristics of the institution. Our phase I pilot trial targeted adult patients who reported the capacity to use a mobile app or desktop website presenting to our HPB transplant clinic at MedStar Georgetown University Hospital/Lombardi Comprehensive Cancer Center over two months. Usability, functionality, and reliability testing were conducted by applying multiple strategies, including biometric data analysis, task completion, questionnaires, and interviews.

Results
Out of 22 patients, 18 (81.8%) completed the in-app survey whose responses were included in the analysis. The usability rate of PatientNav among patient app users was 95.4%. Among patient app users who completed the in-app survey questionnaire, 66.6% reported that the content in the PatientNav app was relevant. In terms of the app's reliability, none of the patient app users reported technical issues with accessing PatientNav throughout the study period. To further elucidate the characteristics of individuals who exhibited high usage of the PatientNav assigned task functions, we divided our cohort based on the median number of tasks used (N = 75 total tasks). The univariable comparison showed that high function users were older, with a median (IQR) age of 61.5 (57.8, 71.3) compared to 52.2 (34.5, 65.7) years among low function users. No differences were observed based on gender, racial distribution, living condition, or occupation. However, 41.7% of low function users had Medicare/Medicaid insurance, whereas all high function users had private or combined insurance.

Conclusion
Our phase I pilot study showed that PatientNav is a feasible, usable, and functional technological tool that enables patients with complex HPB diagnoses and their care team to interface in real-time using patient-reported outcome measures (PROMs). PatientNav is a reliable tool that can be used by clinical and support staff to help navigate patients through surgery and aftercare and by patients to assist in navigation and self-management.

Trial registration
The trial was registered at ClinicalTrials.gov; Registration number: NCT04892927; date of registration: 5/19/2021.
Natural Language Processing–Assisted Classification Models to Confirm Monoclonal Gammopathy of Undetermined Significance and Progression in Veterans' Electronic Health Records
Authors: Wang Mei , Yu Yao-Chi , Liu Lawrence , Schoen Martin W. , Kumar Akhil , Vargo Kristin , Colditz Graham , Thomas Theodore , Chang Su-Hsin 
Published: December 2023

PURPOSE To develop and validate natural language processing (NLP)–assisted machine learning (ML)–based classification models to confirm diagnoses of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) from electronic health records (EHRs) in the Veterans Health Administration (VHA). MATERIALS AND METHODS We developed precompiled lexicons and classification rules as features for the following ML classifiers: logistic regression, random forest, and support vector machines (SVMs). These features were trained on 36,044 EHR documents from a random sample of 400 patients with at least one International Classification of Disease code for MGUS diagnosis from 1999 to 2021. The best-performing feature combination was calibrated in the validation set (17,826 documents/200 patients) and evaluated in the testing set (9,250 documents/100 patients). Model performance in diagnosis confirmation was compared with manual chart review results (gold standard) using recall, precision, accuracy, and F1 score. For patients correctly labeled as disease-positive, the difference between model-identified diagnosis dates and the gold standard was also computed. RESULTS In the testing set, the NLP-assisted classification model using SVMs achieved best performance in both MGUS and MM confirmation with recall/precision/accuracy/F1 of 98.8%/93.3%/93.0%/96.0% for MGUS and 100.0%/92.3%/99.0%/96.0% for MM. Dates of diagnoses matched (±45 days) with those of gold standard in 73.0% of model-confirmed MGUS and 84.6% of model-confirmed MM. CONCLUSION An NLP-assisted classification model can reliably confirm MGUS and MM diagnoses and dates and extract laboratory results using automated interpretation of EHR data. This algorithm has the potential to be adapted to other disease areas in VHA EHR system.
Motivating Experts to Contribute to Digital Public Goods: A Personalized Field Experiment on Wikipedia
Authors: Chen Yan , Farzan Rosta , Kraut Robert , YeckehZaare Iman , Zhang Ark Fangzhou 
Published: December 2023

We conducted a large-scale personalized field experiment to examine how match quality, recognition, and social impact influence domain experts’ contributions to Wikipedia. Forty-five percent of the experts expressed willingness to contribute in the baseline condition, whereas 51% (a 13% increase over the baseline) expressed interest when they received a signal that an article matched their expertise. However, none of the treatments had a significant effect on actual contributions. Instead experts contributed longer and better comments when the actual match between a recommended Wikipedia article and an expert's expertise, measured by cosine similarity, was higher, when they had higher reputation, and when the original article was longer. These findings suggest that match quality between volunteers and tasks is critically important in encouraging contributions to digital public goods and likely to volunteering in general. This paper was accepted by David Simchi-Levi, behavioral economics and decision analysis. Funding: This work was supported by the National Science Foundation through [Grant SES-1620319] awarded to Carnegie Mellon University and the University of Michigan. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4852 .
Pemanfaatan Software SPSS untuk Analisis Instrument Penelitian Dalam Penelitian Tindakan Kelas
Authors: Mutakin Deden 
Published: December 2023

Dalam kegiatan PTK instrument tes (soal) yang digunakan sebagai alat ukur untuk mengukur keberhasil suatu metode atau tindakan perlu diuji kualitasnya. Penelitian ini merupakan penelitian kuantitatif dengan metode deskriptif. Penelitian ini dimaksudkan untuk mencari informasi dan data yang dapat digunakan untuk mendeskripsikan kualitas instrumen tes secara empiris berdasarkan unsur validitas, reliabilitas, indeks kesukaran, dan daya pembeda soal yang diolah dengan bantuan software SPSS versi 16.0. Diagnostik soal dengan menguji cobakan soal kepada 42 siswa kelas VIII B Madarash Muallimin Muhammadiyah Yogyakarta. Hasil uji coba didapatkan 20 item soal baik instrument tes subtema 1 dan 2 kesemuanya valid dan reliable. Tingkat kesukaran instrument tes subtema 1 terdapat 4 soal kategori sedang dan 16 soal kategori mudah. Instrumen tes subtema 2 terdapat 10 soal kategori sedang dan 10 soal kategori mudah. Uji daya pembeda instrument tes subtema 1 kesemua soal dalam kategori baik. Instrument tes subtema 2 terdapat 19 soal dengan kategori baik dan 1 soal dengan kategori tidak baik. Manfaat setelah dilakukan analisis instrumen soal menggunakan SPSS ini adalah dapat membantu dalam evaluasi atas tes yang digunakan, mendukung penulisan butir soal yang efektif, menentukan apakah suatu fungsi butir soal sesuai dengan yang diharapkan, dan merevisi materi yang dinilai atau diukur.
A PRIMEIRA ESCRITORA DO MUNDO: NOTAS SOBRE ENREDUANA, DE ROGER MELLO E MARIANA MASSARANI
Authors: Passos Ramalhete Mariana , Gonçalves Marotto Rafael 
Published: December 2023

Este artigo se propõe a discutir a importância do livro Enreduana, escrito por Roger Mello e ilustrado por Mariana Massarani, publicado em 2018, para a formação estética de jovens leitores. Trata-se de um livro que aborda a história da primeira escritora e filósofa do mundo. Por sua notória qualidade, o livro foi finalista do prêmio Jabuti em 2019, nas categorias Melhor livro infantil e Melhor ilustração, laureado com a melhor ilustração e Hors-Concours na categoria Jovem do Prêmio da Fundação Nacional do Livro Infantil e Juvenil (FNLIJ) de 2019 e na categoria "melhor obra estrangeira" recebeu o Prêmio Internacional de Literatura Infantil Chen Bochui (Cicla) (REIS, 2019). Categoriza-se metodologicamente como uma pesquisa qualitativa de procedimento documental. Apresenta, inicialmente, considerações inerentes às mudanças da literatura infantojuvenil, quer seja no deslocamento de viés pedagógico que lhe deu origem, quer seja na abordagem temática. São contempladas também as discussões inerentes à formação de leitores, à temática da obra, ao projeto gráfico, às ilustrações, em diálogo com questões de gênero. A pesquisa conclui que o rico trabalho materializado em Enreduana justifica sua necessidade de abordagem também no contexto educacional, uma vez que em diálogo com a história e por meio da linguagem metafórica utilizada, plurissignificativa, desconstrói a abordagem uma marginalizada do gênero feminino, imposta pelo patriarcado.
Contribuições da Iniciação Científica para a área de educação agrícola: formação inicial de agrônomos no Instituto Federal Goiano campus Urutaí
Authors: Gonçalves Suzany Faíny , Goulart Silvia Moreira 
Published: December 2023

Buscamos trazer à discussão as contribuições da atividade de iniciação científica para a formação inicial no ensino superior. Focalizamos o curso de bacharelado em agronomia ofertado pelo IF Goiano Campus Urutaí. Análises da participação nas atividades de IC têm sido insuficientemente estudadas no âmbito do IF Goiano. Em um estudo de caso qualitativo, combinamos pesquisa bibliográfica e documental. A análise de dados aponta para a emergência de uma cultura científica no âmbito do curso de Agronomia intimamente associada à articulação de atividades curriculares e extracurriculares, na tríade ensino-pesquisa-extensão, que fomentam a consolidação de um ethos da pesquisa científica na instituição, e que se traduz no envolvimento dos estudantes numa prática investigativa.
Does changes in unicompartmental knee arthroplasty practice pattern influence reasons for revision?
Authors: Mikkelsen Mette , Rasmussen Lasse E. , Price Andrew , Pedersen Alma B. , Gromov Kirill , Troelsen Anders 
Published: December 2023

AimsThe aim of this study was to describe the pattern of revision indications for unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) and any change to this pattern for UKA patients over the last 20 years, and to investigate potential associations to changes in surgical practice over time.MethodsAll primary knee arthroplasty surgeries performed due to primary osteoarthritis and their revisions reported to the Danish Knee Arthroplasty Register from 1997 to 2017 were included. Complex surgeries were excluded. The data was linked to the National Patient Register and the Civil Registration System for comorbidity, mortality, and emigration status. TKAs were propensity score matched 4:1 to UKAs. Revision risks were compared using competing risk Cox proportional hazard regression with a shared γ frailty component.ResultsAseptic loosening (loosening) was the most common revision indication for both UKA (26.7%) and TKA (29.5%). Pain and disease progression accounted for 54.6% of the remaining UKA revisions. Infections and instability accounted for 56.1% of the remaining TKA revision. The incidence of revision due to loosening or pain decreased over the last decade, being the second and third least common indications in 2017. There was a decrease associated with fixation method for pain (hazard ratio (HR) 0.40; 95% confidence interval (CI) 0.17 to 0.94) and loosening (HR 0.29; 95% CI 0.10 to 0.81) for cementless compared to cemented, and units UKA usage for pain (HR 0.67, 95% CI 0.50 to 0.91), and loosening (HR 0.51; 95% CI 0.37 to 0.70) for high usage.ConclusionThe overall revision patterns for UKA and TKA for the last 20 years are comparable to previous published patterns. We found large changes to UKA revision patterns in the last decade, and with the current surgical practice, revision due to pain or loosening are significantly less likely.Cite this article: Bone Jt Open 2023;4(12):923–931.