bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Model Problem Based Learning (PBL) dengan Media Konkret untuk Meningkatkan Pembelajaran Matematika tentang Bangun Ruang pada Siswa Kelas V SD Negeri 3 Kepil Tahun Ajaran 2022/2023
Authors: Nur Aini Zakia , Wahyudi Wahyudi , Ngatman Ngatman 
Published: January 2024

<p>Tujuan penelitian ini adalah mendekripsikan langkah-langkah <em>Problem Based Learning</em> dengan media konkret, meningkatkan pembelajaran matematika, serta mendeskripsikan kendala dan solusi yang ditemui dalam pembelajaran. Penelitian ini menggunakan Penelitian Tindakan Kelas. Subjek penelitian ialah guru dan siswa kelas V SDN 3 Kepil. Data yang digunakan berupa data kualitatif dan kuantitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan tes. Validitas data menggunakan triangulasi sumber dan teknik. Analisis data dilaksanakan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan peningkatan pembelajaran matematika dengan model <em>Problem Based Learning</em> dengan media konkret. Ketuntasan hasil belajar siswa siklus I= 82,5%, siklus II= 85%, dan siklus III= 90%. Kendala yang ditemui yaitu siswa kurang aktif dalam pembelajaran. Dapat disimpulkan bahwa penerapan model <em>Problem Based Learning</em> dengan media konkret dapat meningkatkan pembelajaran matematika tentang bangun ruang pada siswa kelas V SDN 3 Kepil tahun ajaran 2022/2023.</p><br /><div id="pip-toast"> </div>
Efek Kepemimpinan Partisipatif Dalam Pengaruh Praktek Berbagi Pengetahuan Terhadap Kinerja
Authors: Susanto Teguh Trianung Djoko , Soraya Evitha , Muhidin Aeng , Doriza Shinta 
Published: January 2024

Tantangan yang dihadapi SMK menuntut para guru untuk melakukan inovasi. Untuk mendorong kinerja inovatif, dua faktor penting yang perlu dipertimbangkan adalah kepemimpinan partisipatif dan praktek berbagi pengetahuan di antara karyawan. Untuk mengetahui pengaruh kepemimpinan partisipatif dan praktek berbagi pengetahuan terhadap kinerja inovatif, studi korelasional dilakukan. Survei melibatkan 268 guru SMK di DKI Jakarta. Hasil menunjukkan bahwa praktek berbagi pengetahuan dan kepemimpinan partisipatif terhadap kinerja inovatif. Pentingnya manajemen menyediakan sistem dan platform yang memfasilitasi praktek berbagi pengetahuan dan memberikan insentif yang cukup terhadap partisipasi dan kontribusi karyawan pada inovasi.
Pengaruh Media Animasi Terhadap Karakter Peduli Lingkungan Siswa SD Kelas 3 Pada Pembelajaran IPA
Authors: Nugraha Widdy Sukma , Rachmawati Asye 
Published: January 2024

<p>Pentingnya sikap peduli terhadap lingkungan memiliki peranan sentral dalam mengaplikasikan konsep pembelajaran Ilmu Pengetahuan Alam (IPA) dalam kehidupan sehari-hari adalah dengan mengembangkan media pembelajaran menggunakan teknologi seperti media video animasi, untuk menyampaikan informasi kepada anak-anak mengenai masalah sampah. Tujuan dari penelitian ini adalah memastikan bahwa implementasi pembelajaran dapat mencapai hasil maksimal dengan dukungan media animasi. Metode penelitian yang diterapkan adalah tipe desain kuantitatif pre-eksperimental, dengan menggunakan pendekatan One Group Pretest Posttest. Hasil analisis data yang telah dilakukan di SD Pananjung Garut menunjukkan bahwa hasil hipotesis menunjukkan nilai thitung ≤ ttabel, dengan nilai 6,698 ≤ 1,711, sehingga Ho ditolak dan Ha diterima. Oleh karena itu, dapat disimpulkan bahwa media animasi memiliki pengaruh terhadap pembentukan karakter peduli lingkungan pada siswa SD Kelas 3.</p><div id="pip-toast"> </div><div id="pip-toast"> </div><div id="pip-toast"> </div>
Different Antithrombotic Strategies after Coronary Artery Bypass Grafting to Prevent Adverse Events
Authors: Shi Yi , Zhang Li-xue , Chen Shenglong , Liu Gang , Lian Bo 
Published: January 2024

Abstract
Objective:
Coronary artery bypass grafting (CABG) is associated with antithrombotic therapy in terms of postoperative adverse events; however, it is still unknown whether the early use of such drugs after CABG is safe and effective. In this study, we aim to evaluate the relationship between different postoperative antithrombotic strategies and in-hospital adverse events in patients undergoing isolated coronary artery bypass grafting surgery.
Methods:
This was a single-center, retrospective cohort analysis of patients undergoing isolated CABG due to CAD between 2001 and 2012. Data were extracted from the Medical Information Mart for Intensive Care III database.The patients involved were divided into the ASA (aspirin only) or DAPT (aspirin plus clopidogrel) group according to the antiplatelet strategy. Patients were also stratified into subgroups based on the type of anticoagulation. The risk of bleeding and adverse events was investigated and compared between groups.
Results:
A total of 3274 patients were included in this study, with 2358 in the ASA group and 889 in the DAPT group. No significant difference was seen in the risk of major bleeding between the two groups according to the PLATO, TIMI or GUSTO criteria. There was no difference in the postoperative mortality. In subgroup analysis, patients given anticoagulant therapy had an increased incidence of bleeding-related events. Multivariable analysis revealed that postoperative anticoagulant therapy and the early use of heparin, but not DAPT, were independent predictors of bleeding-related events.
Conclusions:
Postoperative DAPT was not associated with an increased occurrence of bleeding-related events in patients undergoing isolated CABG and appears to be a safe antiplatelet therapy. The addition of anticoagulants to antiplatelet therapy increased the risk of bleeding and should be considered cautiously in clinical practice.
Two novel single-chain variable fragments exert bactericidal activity against Acinetobacter baumannii through destabilization of the outer membrane
Authors: Rahimi-Jamnani Fatemeh 
Published: January 2024

Abstract
Acinetobacter baumannii is notorious for its high levels of resistance and the development of clinically-effective antimicrobial agents seems to be an urgent medical challenge. Bactericidal single-chain variable fragments (scFvs) are novel antibacterial agents capable of inhibiting the growth of pathogens (e.g. Staphylococcus aureus, Pseudomonas aeruginosa, A. baumannii) independently of the host immune system. We previously found that two fully human scFvs, EB211 and EB279, showed direct growth inhibition against A. baumannii strains in vitro and demonstrated therapeutic effectiveness in immunocompromised mice with pneumonia caused by an extensively drug-resistant A. baumannii strain. In the current study, the antibacterial activity of EB211 and EB279 against A. baumannii, Klebsiella pneumonia, and P. aeruginosa strains was appraised in the presence of a high concentration of magnesium (Mg2+; 20 mM) to find the bactericidal mechanism of these two scFvs. Furthermore, epitope mapping was performed to identify A. baumanniiproteins that might be bound by EB211 and EB279. It was found that EB211 and EB279, similar to colistin sulfate, lost their activity in the presence of Mg2+. Indeed, both EB211 and EB279 exerted their growth inhibitory activity through displacing Mg2+ and interrupting the integrity of the outer membrane. Taken together, EB211 and EB279 by disruption of the outer membrane A. baumannii elicit their main direct growth inhibitory activity against A. baumannii without the need for immune cells or complements.
Alterations of plasma neuron-derived exosomal microRNAs in patients with bipolar disorder
Authors: Li Tao , Qi Xueyu , Jiang Han , Ren Bin , Zhang Yamin , Zhou Yuqiang , Wu Jianming , Yu Xueli , Ni Peiyan , Xu Yan , Deng Wei , Guo Wanjun , Hu Xun 
Published: January 2024

Abstract
MicroRNAs (miRNAs) alterations in patients with bipolar disorder (BD) are pivotal to the disease’s pathogenesis. Since obtaining brain tissue is challenging, most research has shifted to analyzing miRNAs in peripheral blood. One innovative solution is sequencing miRNAs in plasma exosomes, particularly those neuron-derived exosomal miRNAs emanating from the brain. In our study, we isolated plasma neuron-derived exosomes from 85 patients with BD and 39 healthy controls using biotinylated antibodies targeting a human neuronal marker. These exosomes were then subjected to miRNA sequencing and expression analysis. Out of the 2,656 neuron-derived exosome miRNAs identified, 14 were differentially expressed between BD patients and controls. This differential expression was consistent even when the sample was split into discovery and validation groups. Notably, the expression trend remained unchanged between patients in either the depressive or manic phase. Moreover, the target genes of hsa-miR-143-3p displayed distinct expression patterns in the prefrontal cortex of BD patients versus healthy controls, as sourced from PsychENCODE data. Through weighted gene co-expression network analysis, a module linking to clinical symptoms of BD patients was discerned. Enrichment analyses unveiled these miRNAs’ role in modulating the PI3K-AKT signaling pathway, axon guidance, and focal adhesion. To summarize, our findings provide the first evidence of dysregulated plasma neuron-derived exosome miRNAs in BD patients, further buttressing the neurogenic hypothesis of BD.
Innovative Soil Fluoride Estimation Method: Dual Polarimetric Saline-Associated Fluoride for Agricultural Patches
Authors: Krishnan Vijayasurya , Asaithambi Manimaran 
Published: January 2024

Abstract
Fluoride and its constituents in soil affect plant growth and public health. In this study soil fluoride was measured for the semi-arid regions in southern India, using Sentinel-1 data in conjunction with the Dual Polarimetric Saline Associated Fluoride model (also known as Fluoride model). A loss angle was estimated from laboratory-based dielectric components of soil samples with strong electrical conductivity under high and low fluoride conditions. The conductivity loss angle, real and imaginary dielectric constants were used to study fluoride salt's dielectric behaviour. The imaginary dielectric component sensitive to dielectric loss could predict fluoride across large areas over time. This was statistically analysed with R2 = 0.86, RMSE = 1.90, and Bias = 0.35 showing a promising depiction that C-band SAR data can distinguish fluoride levels over varied clay soil and soil with varying vegetation development. Moreover, the association between biomass and simulated fluoride helped to identify fluoride-tolerant and non-tolerant crops. The study found that Sorghum and Oryza sativa tolerate saline-associated fluoride, whereas Peanut and Allium do not. Furthermore, the model successfully retrieves fluoride from saline salts based on tangent loss.
Sacral Neuromodulation for Constipation and Fecal Incontinence in Children and Adolescents – study protocol of a prospective, randomized trial on the application of invasive vs. non-invasive technique
Authors: Besendörfer Manuel , Kirchgatter Annemarie , Carbon Roman , Weiss Christel , Müller Hanna , Matzel Klaus , Diez Sonja 
Published: January 2024

Abstract
Background
A therapeutic effect of sacral neuromodulation (SNM) on fecal incontinence (FI) and quality of life has been proven in adults. SNM is, however, rarely used in pediatric cases. The aim of the study is to investigate effects of SNM in pediatric constipation in a prospective parallel-group trial.
Methods
A monocentric, randomized, unblinded, parallel-group trial is conducted. SNM is conducted in the invasive variant and in an innovative, external approach with adhesive electrodes (enteral neuromodulation, ENM). We include patients with constipation according to the ROME IV criteria and refractory to conventional options. Patients with functional constipation and Hirschsprung’s disease are able to participate. Participants are allocated in a 1:1 ratio to either SNM or ENM group. Clinical data and quality of life is evaluated in regular check-ups. Neuromodulation is applied continuously for 3 months (end point of the study) with follow-up-points at 6 and 12 months. Findings are analyzed statistically considering a 5% significance level (p ≤ 0.05). Outcome variables are defined as change in (1) episodes of abdominal pain, (2) episodes of FI, (3) defecation frequency, (4) stool consistency. Improvement of proprioception, influence on urinary incontinence, quality of life and safety of treatment are assessed as secondary outcome variables. We expect a relevant improvement in both study groups.
Discussion
This is the first trial, evaluating effects of neuromodulation for constipation in children and adolescents and comparing effects of the invasive and non-invasive application (SNM vs. ENM).
Trial registration
The study is registered with clinicaltrials.gov, Identifier NCT04713085 (date of registration 01/14/2021).
Cancer associated fibroblasts mitigate the efficacy of the combination of chemotherapy and BCL-xL targeting in triple negative breast cancer cells
Authors: Souazé Frédérique , Nocquet Lisa , Roul Julie , Duarte Laurine , Campone Mario , Juin Philippe 
Published: January 2024

Abstract
Triple negative breast cancers (TNBC) present a poor prognosis primarily due to their resistance to chemotherapy. This resistance is understood to associate with elevated expression of certain anti-apoptotic members within the proteins of the BCL-2 family (namely BCL-xL, MCL-1 and BCL-2). These regulate cell death by inhibiting pro-apoptotic protein activation through binding and sequestration and they can be selectively antagonized by BH3 mimetics. Yet the individual influences of BCL-xL, MCL-1, and BCL-2 on the sensitivity of TNBC cells to chemotherapy, and their regulation by cancer-associated fibroblasts (CAFs), major components of the tumor stroma and key contributors to therapy resistance remain to be delineated. By utilizing engineered cell lines deficient in BCL-2 family proteins and BH3 mimetics, we show that BCL-xL and MCL-1 promote the survival of two TNBC cell lines by compensatory mechanisms. These cell lines show limited sensitivity to chemotherapy, in line with the clinical resistance observed in TNBC patients. We elucidate that BCL-xL plays a pivotal role in therapy response, as its depletion or pharmacological inhibition heightened chemotherapy effectiveness. Moreover, BCL-xL expression is associated to chemotherapy resistance in patient-derived tumoroids where its pharmacological inhibition enhances ex vivo response to chemotherapy. In a co-culture model of cancer cells and CAFs, we observe that even in a context where BCL-xL inhibition renders cancer cells more susceptible to chemotherapy, those in contact with CAFs display reduced sensitivity to chemotherapy. Thus CAFs exert a profound pro-survival effect in breast cancer cells, even in a setting highly favoring cell death through combined chemotherapy and inhibition of the main actor of chemoresistance, BCL-xL.
Differential analysis of inflammatory markers in benign and malignant bone tumor patients based on a large cohort of cases
Authors: Zhao JiaQi , Dong Zhenyu , Tao Xiaoliang , Song Lei , Zhang Shuai 
Published: January 2024

Abstract
Objective
To explore the relationship between inflammatory markers and the benign-malignant nature as well as tumor staging of primary bone tumors using a comprehensive analysis of a substantial cohort of cases.
Methods
Clinical data of patients with primary bone tumors in the limbs were collected. Subsequently, patients were classified into two distinct groups: benign bone tumors group and primary malignant bone tumors group. Various inflammatory markers including neutrophil count, lymphocyte count, and platelet count were recorded from preoperative complete blood cell counts. Additionally, the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated. The potential differences in these aforementioned inflammatory markers between the two groups were compared and analyzed. Furthermore, based on the Enneking tumor staging, patients from the two group were reassigned into subgroups, respectively, and these inflammatory markers among patients at different tumor stages were compared and analyzed.
Results
A total of 315 patients with benign bone tumors and 256 patients with primary malignant bone tumors were included in this study. In terms of inflammatory markers, the mean neutrophil count, the mean platelet count, the mean NLR value and the mean PLR value were 3.45 ± 1.13, 213.56 ± 58.19, 1.92 ± 0.79 and 118.86 ± 42.43 in the benign bone tumor group and 4.14 ± 1.65, 235.32 ± 74.45, 2.48 ± 1.74 and 136.77 ± 67.91 in the malignant bone tumor group (P < 0.05). In the benign group, there were 110 patients in Enneking stage 1 and 33 patients in stage 3. The mean neutrophil count and the mean lymphocyte count were 3.12 ± 0.97, 1.85 ± 0.54 in stage 1 and 3.86 ± 1.25, 2.11 ± 0.63 in stage 3 (P < 0.05). While in the malignant group, there were 38 patients in Enneking stage I and 31 patients in stage III. The mean neutrophil count, the mean NLR value and the mean PLR were 3.61 ± 1.06, 1.93 ± 0.82, 118.80 ± 43.39 in stage I and 4.77 ± 2.18, 3.17 ± 2.76, 149.15 ± 70.24 in stage III (P < 0.05).
Conclusion
This study provides clinical evidence supporting the close relationship between inflammation and the pathogenesis of primary bone tumors. It reveals that patients with primary malignant bone tumors exhibit significantly elevated levels of inflammatory markers, compared to those with benign bone tumors.
Trustworthiness of Artificial Intelligence – Powered Autonomous Healthcare Systems: An Assessment Framework Informed byExperts Insights
Authors: Alelyani Turki 
Published: January 2024

Abstract
The increasing prevalence of Autonomous Systems (AS) powered by Artificial Intelligence (AI) in society and their expanding role in ensuring safety necessitate the assessment of their trustworthiness. The verification and development com- munity faces the challenge of evaluating the trustworthiness of AI-powered AS in a comprehensive and objective manner. To address this challenge, this study conducts a semi-structured interview with experts specializing in AI and autonomous systems in healthcare to gather their insights and perspectives on the trustworthiness of AI-powered autonomous systems. By integrating these expert insights, a comprehensive framework is proposed for assessing the trustworthiness of AI-powered autonomous systems in the domain of healthcare. This framework is designed to contribute to the advancement of trustworthiness assessment practices in the field of AI and autonomous systems, fostering greater confidence in their deployment in healthcare settings.
An artificial intelligence-based model to reduce the no-show rate in outpatient clinics of an academic hospital
Authors: Aij Kjeld , Knoester Josta , Werkhoven Ben 
Published: January 2024

Abstract
Purpose
non-attendance of patients for outpatient appointments, known as "no-shows," poses a persistent challenge for healthcare facilities, with significant repercussions for both patients and healthcare systems. This study aimed to investigate whether targeting high-risk individuals with interventions could effectively reduce the rate of no-shows within reasonable resource allocation.
Methods
we developed an artificial intelligence (AI) algorithm-based prediction model to estimate the likelihood of an appointment resulting in a no-show. Utilizing retrospective data from 24 outpatient clinics, a machine learning (ML) model was constructed and trained to identify patients at high risk of no-show. Subsequently, over a 6-month period, 35% of the highest-risk patients were randomly assigned to either the intervention group (receiving a reminder phone call three workdays before their appointment) or the control group (no reminder call).
Results
following the intervention, the intervention group experienced a notable 26.2% reduction in no-shows. This reduction translates to a 14.3% decrease in the overall number of no-shows, demonstrating the efficacy of the reminder service. Moreover, this intervention led to additional benefits, including the ability to schedule new patients on previously avoided no-show slots, enhanced patient experience, reduced staff preparation time for missed appointments, and a decrease in administrative burden associated with rescheduling no-shows.
Conclusions
Our AI-powered model proved to be an effective tool for identifying high-risk patients prone to missing their outpatient appointments. This allowed for targeted interventions, such as reminder phone calls, to be implemented. The substantial reduction in no-show rates underscores the potential impact of this approach on optimizing healthcare resource allocation and improving patient attendance.
Chidamide combined with a modified Bu-Cy conditioning regimen improves survival in patients with T-cell acute lymphoblastic leukemia/lymphoma undergoing allogeneic hematopoietic stem cell transplantation.
Authors: Cao Xuanqi , Li Zheng , Zhang Yanming , Cui Qingya , Dai Haiping , Ma Yunju , Li Mengyun , Chen Sifan , Yin Jia , Cui Wei , Chen Jia , Sun Aining , Qiu Huiying , Chen Suning , Zhu Xiaming , Andersson Borje S. , Wu Depei , Tang Xiaowen 
Published: January 2024

Abstract

This study aimed to evaluate the efficacy and safety of chidamide (Chi) combined with a modified Busulfan-Cyclophosphamide (mBuCy) conditioning regimen for T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-two patients received chidamide combined with mBuCy conditioning regimen (Chi group). A control (CON) group of 82 patients received mBuCy only in the same period. The leukemia-free survival (LFS), overall survival (OS), cumulative incidence of relapse (CIR), and non-relapse-related mortality (NRM) were evaluated. Patients in the Chi group were associated with lower 2-year CIR (19.0 vs. 38.4%, P= 0.030), better 2-year LFS (76.1 vs. 51.6%, P = 0.027), and had a trend towards better 2-year OS (80.5 vs. 60.4%, P= 0.063). Patients with minimal residual disease (MRD) positive before HSCT in the Chi group exhibited an advantage in 2-year OS and LFS, despite no significant differences (75.0 vs. 18.6%, P = 0.068; 75.0 vs. 24.1%, P = 0.070, respectively). The cumulative incidence rates of grade II-IV aGVHD were similar (36.4 vs. 39.0%, P = 0.820). The most common non-hematologic adverse event was gastrointestinal tract. Hepatic dysfunction was more often observed in the Chi group. 20 patients in Chi group evinced an elevation in γ-glutamyltransferase, as compared to the mBuCy group (90.9 vs. 65.9%, P= 0.021). No transplantation-related mortality was documented within the first 100 days after transplantation. The results demonstrate that the chidamide intensified regimen may be an effective and acceptable safety option for T-ALL/LBL undergoing allo-HSCT.