bluuebunny/crossref_metadata_2025_split huggingface dataset:
PET‐Based Dual‐Modal Probes for In Vivo Imaging
Authors: Zhao Runge , Lan Deren , Xia Beibei , Dong MengJie , Mu Jing , Zhao Yongsheng 
Published: January 2025

AbstractMolecular imaging has significantly advanced the detection and analysis of in vivo metabolic processes, while single‐modal techniques remain limited. Dual‐modal imaging, particularly positron emission tomography (PET)‐based combinations has emerged as a powerful solution, offering enhanced capabilities through integration with magnetic resonance imaging (MRI) or near‐infrared fluorescence (NIRF) imaging. This review highlights recent progress in PET‐based dual‐modal imaging, focusing on the development of various bimodal probes derived from antibodies, nanoparticles, and peptides, and key applications including image‐guided surgery and disease assessment. PET‐based dual‐modal imaging holds substantial potential for advancing research and diagnostics by improving resolution and providing functional insights. By combining complementary modalities, these systems deliver a more comprehensive view of disease processes, leading to more accurate diagnoses and targeted treatments. Future research prioritizes optimizing probe design for enhanced biocompatibility and safety, facilitating clinical translation, and broadens applications beyond cancer. Through interdisciplinary collaboration, PET‐based dual‐modal probes are poised to play a pivotal role in improving patient outcomes, particularly in diagnosing and managing complex diseases.
Die Forstwegbrücke BW 399c im Zuge der BAB A3
Authors: Mansperger Tobias , Lewerenz Camilla , Hofmann Max 
Published: January 2025

AbstractKlima‐ und ressourcenschonendes Bauen gehört zu den größten Herausforderungen unserer Zeit und erfordert innovative Ansätze im Ingenieur‐ und Brückenbau. Mit dem BW 399c wurde ein besonders nachhaltiges Brückenbauwerk realisiert, das diesen Anforderungen in besonderer Weise gerecht wird. Es zeichnet sich durch seine innovative Bauweise, die Kombination mehrerer innovativer Technologien und höchste gestalterische Ansprüche aus. Die Brücke überspannt die Bundesautobahn A3 im Bereich der Gemeinde Schwaig nahe Nürnberg und wurde gemäß den Richtlinien des Gestaltungshandbuchs der A3 für den sechsstreifigen Ausbau zwischen Nürnberg und Würzburg als Typ‐2‐Bauwerk errichtet. Dieses Konzept hatte sich bereits beim benachbarten Bauwerk 400c bewährt, welches mit einer Auszeichnung im Rahmen des Wettbewerbs zum Deutschen Brückenbaupreis 2020 prämiert wurde – im Jahr 2024 folgte auch für das BW 399c eine Auszeichnung im Rahmen des Ingenieurpreises des Deutschen Stahlbaus. Erstmals wurde beim Bauwerk 399c eine Straßenbrücke mit Orthoverbundplatte mit Verbunddübelleisten und nichtmetallischer Bewehrung ausgeführt. Der Überbau einschließlich der Fahrbahn, Kappen und Geländer wurde nahezu vollständig in Seitenlage vorgefertigt und während einer einzigen nächtlichen Sperrpause in seine endgültige Position eingefahren.
Strategies for Service Growth
Authors: Odhe JanErik , Padhi Pritam , Witell Lars 
Published: January 2025

Abstract
In the competitive world of manufacturing, where profit margins deteriorate over time, service infusion might be a way to help a business turn in the right direction. This chapter briefly explains the concepts of servitization and service infusion, before identifying service growth opportunities and obstacles. From a strategy-based perspective, we present a conceptual model that evaluates the current and future growth potential of the service business. We identify four specific service growth strategies and illustrate them through business cases. The service growth strategies represent physical services (free-to-fee and ownership change) and digital services (remote and upgrading).
Enabling a Circular Economy Through Green Service Strategies
Authors: Hedvall Klas , Witell Lars 
Published: January 2025

Abstract
Services are key enablers in the transformation toward the circular economy because they provide the prerequisites for sustainable value co-creation. Services in the circular economy include “traditional” offerings such as maintenance and remanufacturing, but also newer types of services in the sharing economy. This chapter discusses three sustainable value co-creation activities in more detail: (1) extending product life, (2) dematerialization, and (3) replacing service systems. It also provides illustrations of services that support sustainable value co-creation and, ultimately, improved environmental sustainability. The chapter concludes by highlighting key challenges for firms and customers involved in sustainable value co-creation activities.
Polynomial Fourier decay for fractal measures and their pushforwards
Authors: Baker Simon , Banaji Amlan 
Published: January 2025

Abstract
We prove that the pushforwards of a very general class of fractal measures

$$\mu $$

μ

on

$$\mathbb {R}^d$$

R

d

under a large family of non-linear maps

$$F{:}\,{\mathbb {R}}^d \rightarrow {\mathbb {R}}$$

F
:

R

d

→
R

exhibit polynomial Fourier decay: there exist

$$C,\eta >0$$

C
,
η
>
0

such that

$$|\widehat{F\mu }(\xi )|\le C|\xi |^{-\eta }$$

|

F
μ

^

(
ξ
)

|
≤
C
|
ξ
|

-
η

for all

$$\xi \ne 0$$

ξ
≠
0

. Using this, we prove that if

$$\Phi = \{ \varphi _a{:}\,[0,1] \rightarrow [0,1]\}_{a \in \mathcal {A}}$$

Φ
=

{

φ
a

:

[
0
,
1
]

→

[
0
,
1
]

}

a
∈
A

is an iterated function system consisting of analytic contractions, and there exists

$$a \in \mathcal {A}$$

a
∈
A

such that

$$\varphi _a$$

φ
a

is not an affine map, then every non-atomic self-conformal measure for

$$\Phi $$

Φ

has polynomial Fourier decay; this result was obtained simultaneously by Algom, Rodriguez Hertz, and Wang. We prove applications related to the Fourier uniqueness problem, Fractal Uncertainty Principles, Fourier restriction estimates, and quantitative equidistribution properties of numbers in fractal sets.
Green quantification of amino(poly)phosphonates using ion chromatography coupled to integrated pulsed amperometric detection
Authors: Röhnelt Anna M. , Martin Philipp R. , Marks Robert G. H. , Buchner Daniel , Weiss Joachim , Schmidt Torsten C. , Haderlein Stefan B. 
Published: January 2025

Abstract
Aminopolyphosphonates (APPs) are widely used as chelating agents, and their increasing release into the environment has raised concerns due to their transformation into aminomethylphosphonic acid (AMPA) and glyphosate, compounds of controversial environmental impact. This transformation highlights the urgent need for detailed studies under controlled conditions. Despite the availability of various methods for quantifying individual aminopolyphosphonates and aminomonophosphonates, a green, low-cost approach for the simultaneous quantification of APPs and their transformation products in laboratory experiments has been lacking. In this study, we present a novel analytical method utilizing ion chromatography (IC) coupled to integrated pulsed amperometric detection (IPAD) to simultaneously quantify the six aminophosphonates: AMPA, glyphosate, iminodi(methylene phosphonate) (IDMP), aminotrismethylene(phosphonates) (ATMP), ethylenediamine tetra(methylene phosphonate) (EDTMP), and diethylenetriamine penta(methylene phosphonate) (DTPMP). This method achieves separation within a 35-min run time and method detection limits (MDLs) ranging from 0.014 μM for AMPA to 0.14 μM for DTPMP. The method’s applicability was successfully shown by monitoring DTPMP, IDMP, and AMPA during DTPMP transformation on manganese dioxide. A key advantage of this method is its environmental friendliness compared to existing aminophosphonate quantification techniques. Next to the simultaneous analysis, it avoids the use of derivatization agents and organic solvents and employs an energy-efficient detector. While the method’s limitations lie in the detector’s inherent non-specific nature, it offers a low-cost and sustainable alternative to existing methods.

Graphical Abstract
[18F]PSMA-1007 PET/CT-based radiomics may help enhance the interpretation of bone focal uptakes in hormone-sensitive prostate cancer patients
Authors: Bauckneht Matteo , Pasini Giovanni , Di Raimondo Tania , Russo Giorgio , Raffa Stefano , Donegani Maria Isabella , Dubois Daniela , Peñuela Leonardo , Sofia Luca , Celesti Greta , Bini Fabiano , Marinozzi Franco , Lanfranchi Francesco , Laudicella Riccardo , Sambuceti Gianmario , Stefano Alessandro 
Published: January 2025

Abstract

Purpose
We hypothesised that applying radiomics to [18F]PSMA-1007 PET/CT images could help distinguish Unspecific Bone Uptakes (UBUs) from bone metastases in prostate cancer (PCa) patients. We compared the performance of radiomic features to human visual interpretation.

Materials and methods
We retrospectively analysed 102 hormone-sensitive PCa patients who underwent [18F]PSMA-1007 PET/CT and exhibited at least one focal bone uptake with known clinical follow-up (reference standard). Using matRadiomics, we extracted features from PET and CT images of each bone uptake and identified the best predictor model for bone metastases using a machine-learning approach to generate a radiomic score. Blinded PET readers with low (n = 2) and high (n = 2) experience rated each bone uptake as either UBU or bone metastasis. The same readers performed a second read three months later, with access to the radiomic score.

Results
Of the 178 [18F]PSMA-1007 bone uptakes, 74 (41.5%) were classified as PCa metastases by the reference standard. A radiomic model combining PET and CT features achieved an accuracy of 84.69%, though it did not surpass expert PET readers in either round. Less-experienced readers had significantly lower diagnostic accuracy at baseline (p < 0.05) but improved with the addition of radiomic scores (p < 0.05 compared to the first round).

Conclusion
Radiomics might help to differentiate bone metastases from UBUs. While it did not exceed expert visual assessments, radiomics has the potential to enhance the diagnostic accuracy of less-experienced readers in evaluating [18F]PSMA-1007 PET/CT bone uptakes.
Hematopoietic stem cell transplantation and immunosuppressive therapy: implications of clonal haematopoiesis
Authors: Tan Zhengwei , Zhang Xinhe , Feng Jia , Zhao Yuechao , Hu Huijin , Wu Dijiong , Yu Qinghong , Zhang Yu , Wu Liqiang , Hu Tonglin , Yan Zhengsong , Ye Baodong , Liu Wenbin 
Published: January 2025

Abstract
Aplastic anemia (AA) is a life-threatening bone marrow failure syndrome. The advent of next-generation sequencing (NGS) has shed light on the link between somatic mutations (SM) and the efficacy of immunosuppressive therapy (IST) in AA patients. However, the relationship between SM and hematopoietic stem cell transplantation (HSCT) has not been extensively explored. In this retrospective analysis, we examined 166 AA patients who received HSCT or IST at our institution between May 2019 and December 2023. NGS was conducted on 66 genes within bone marrow cells to investigate the correlation between SM and the prognosis and therapeutic response in AA patients, as well as to assess the impact of mutation types on HSCT outcomes. Clinical data were gathered from 166 AA patients, comprising 84 males and 82 females, with a median age of 32 years (ranging from 9 to 75 years). In our study, a total of 151 somatic mutations were identified across 84 patients (50.6%), with 42 patients (25.3%) presenting a single mutation and 26 patients (15.7%) harboring two mutations. The top five genes with the highest mutation frequency were BCOR/BCORL1 (12.6%), ASXL1 (8.6%), TET2 (6.6%), CEBPA (5.3%), and GATA2 (4.6%). We stratified patients into SM and No-SM groups based on the presence of mutations and further divided them into HSCT and IST groups to assess the influence of mutation types on treatment response and survival within and between these groups. The findings were as follows: 1.Patients in the HSCT group exhibited a higher treatment response (OR 85.9% vs. 68.4%, p < 0.05), although there was no significant difference in survival. 2.Patients with favorable mutations, such as PIGA and BCOR/BCORL1, experienced significantly improved response and survival compared to those with unfavorable mutations like ASXL1, DNMT3A, and TET2 (OR 93.7% vs. 72%, p < 0.05) (3-year OS 93.7% vs. 80%, p > 0.05). 3.The HSCT-Favorable group demonstrated superior response rates (OR 100% vs. 67.7%, p < 0.05) and longer survival (3-year OS 100% vs. 67.7%, p < 0.05) compared to the IST-Favorable group. This study underscores that AA patients carrying favorable mutations, particularly BCOR/BCORL1, tend to have a more robust response and better prognosis than those without mutations or those with unfavorable mutations, such as ASXL1/DNMT3A. These findings are especially pertinent to HSCT, highlighting the importance of NGS prior to initiating treatment.
Nedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8)
Authors: Sas David J. , Bakkaloglu Sevcan A. , Belostotsky Vladimir , Hayes Wesley , Ariceta Gema , Zhou Jing , Rawson Verity 
Published: January 2025

Abstract

Background
Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and renal failure, with potentially life-threatening systemic oxalosis. Nedosiran is a synthetic RNA interference therapy, designed to reduce hepatic lactate dehydrogenase (LDH) to decrease oxalate burden in PH.

Methods
Currently, in the PHYOX8 study (NCT05001269), pediatric participants (2–11 years) with PH1 (N = 15) and estimated glomerular filtration rate (eGFR) ≥ 30mL/min/1.73m2 received nedosiran once monthly for 6 months.

Results
Urinary oxalate:creatinine (Uox:Ucr) levels reduced by 64% on average. Mean Uox:Ucr reduction was 52% at day 60 and ˃60% at day 180. At one or more study visits, 93.3% (N = 14) of participants reached Uox:Ucr < 1.5 × upper limit of normal (ULN), and 53.3% (N = 8) reached ≤ 1.0 × ULN. Median percent change in plasma oxalate (12.0 µmol/L at baseline) to day 180 was –39.23% (n = 10). Average number of kidney stones per participant remained stable, whilst a 10.1% average decrease in summed surface area was observed. Median percent change from baseline in eGFR was 2.5%, indicating preservation of renal function.

Conclusions
Nedosiran was well tolerated, with only 3 participants experiencing at least one serious adverse event, none considered treatment-related. The incidence of injection site reactions was 6.7% (1/15 participants). In conclusion, nedosiran treatment led to a significant and sustained reduction of Uox levels in children with PH1. These findings support nedosiran treatment in pediatric patients to reduce Uox and shows promise for limiting PH1-related complications.

Graphical abstract
Opportunity-based other-regarding preferences in general equilibrium: existence
Authors: Donato Maria Bernadette , Sperati Chiara , Villanacci Antonio 
Published: January 2025

Abstract
We consider a pure exchange economy with a finite number of goods and households. Following the path-breaking paper by Kranich, we introduce two differences with respect to the standard model: (i) each household utility function depends not only on her own consumption but also on other households’ welfare, measured by wealth; then, other-regarding preferences are based on other households opportunities; (ii) households are allowed to promise transfers to other households and the promises are bound to be honored. We provide a proof of existence of equilibria, solving several problems which are not addressed by the paper by Kranich. We present a robust example of non-existence of equilibria if the crucial assumption of an upper bound on transfers is violated. As a mathematical by-product of our analysis, we give easy-to-check conditions that ensure that commonly used constraint set-valued functions satisfy properties that are needed to apply standard existence theorems.
Auf dem Weg zu einer zirkulären CO2-Wirtschaft? – Der Rechtsrahmen für CCU
Authors: Rösner Verena , Rothfuß Kaja 
Published: January 2025

Zusammenfassung
Die Bundesregierung sieht das Verfahren Carbon Capture and Utilization (CCU) als Innovation mit vielversprechendem
Potenzial im Kampf gegen den Klimawandel. Um die bioökonomische Vision eines geschlossenen Kohlenstoffkreislaufsystems,
in dem CO2 aus Industrieemissionen eingefangen und wiederverwertet wird zu realisieren, hat das Bundesministerium
für Wirtschaft und Klimaschutz im Februar 2024 “Eckpunkte für eine Carbon Management-Strategie”
vorgelegt. Am 21. Juni 2024 folgte ein Gesetzentwurf zur Änderung des Kohlenstoff-Speicherungsgesetzes
(KSpG), der einen Rahmen für den CO2-Transport in Deutschland schaffen soll.
The irreducibility of chemistry to Everettian quantum mechanics
Authors: Miller Ryan Michael 
Published: January 2025

Abstract
The question of whether chemical structure is reducible to Everettian Quantum Mechanics (EQM) should be of interest to philosophers of chemistry and philosophers of physics alike. Among the three realist interpretations of quantum mechanics, EQM resolves the measurement problem by claiming that measurements (now interpreted as instances of decoherence) have indeterminate outcomes absolutely speaking, but determinate outcomes relative to emergent worlds—Maudlin (Topoi, 14:7-15, 1995). Philosophers who wish to be sensitive to the practice of quantum chemistry e.g. Scerri (The changing views of a philosopher of chemistry on the question of reduction, 2016) should be interested in EQM because Franklin and Seifert (J. Philos. Sci, 2020) claim that resolving the measurement problem also resolves the reducibility of chemical structure, and EQM is the interpretation which involves no mathematical structure beyond that used by practicing scientists. Philosophers interested in the quantum interpretation debate should be interested in the reducibility of chemistry because chemical structure is precisely the kind of determinate three-dimensional fact which EQM should be able to ground if it is to be empirically coherent—see Allori (Quantum Rep, 5:80-101, 2023). The prospects for reduction of chemical structure are poor if it cannot succeed in EQM; the prospects for EQM as a guide to ontology are poor if it cannot reduce chemical structure. Unfortunately for proponents of chemical reduction and EQM, there are three serious barriers to the reduction of chemistry to EQM. The first concern is that quantum treatments of chemical structure rely on the Born-Oppenheimer approximation, which holds nuclear locations fixed while minimizing the energy of the electronic configuration—Hendry (Philosophical Perspectives in Quantum Chemistry, 147-172, 2022), but this approximation is not licensed by EQM. The Born-Oppenheimer approximation relies on nuclei and molecular orbitals being simultaneously present, but in the three-dimensional ontology following from the Everett interpretation these only emerge at different energy scales and are not simultaneously present—Miller (Found. Chem, 25:405-417, 2023). The second concern is that the emergent worlds of EQM are supposed to be decoherent at the macro-scale—Wilson (The Nature of Contingency: Quantum Physics as Modal Realism 2020), but the recent development of superchemistry suggests that chemical reactions can occur in coherent states—Zhang et al. (Nat. Phys, 1-5, 2023). The third concern is that emergent worlds are only pragmatic pseudo-processes—Wallace (The Emergent Multiverse: Quantum Theory According to the Everett Interpretation, 2012b), but this means EQM trades realist physics for mere instrumentalism about chemistry. Absent a commitment to chemical realism, reduction is an empty promise. The prospects for reduction of chemical structure to EQM are therefore poor.
Four Neurotoxic Insecticides Impair Partner and Host Finding in the Parasitoid Leptopilina heterotoma and Bioactive Doses Can Be Taken up Via the Host
Authors: Schöfer Nils , Saxinger Nathalie , Braumandl Katrin , Ruther Joachim 
Published: January 2025

Abstract
In modern agriculture, control of insect pests is achieved by using insecticides that can also have lethal and sublethal effects on beneficial non-target organisms. Here, we investigate acute toxicity and sublethal effects of four insecticides on the males’ sex pheromone response and the female host finding ability of the Drosophila parasitoid Leptopilina heterotoma. The nicotinic acetylcholine receptor antagonists acetamiprid, flupyradifurone and sulfoxaflor, as well as the acetylcholinesterase inhibitor dimethoate were applied topically as acetone solutions. Males treated with all four insecticides no longer preferred the female sex pheromone in a T-olfactometer. Duration of wing fanning, an element of the pheromone-mediated male courtship behavior, was also reduced by all four insecticides. The ability of females to orientate towards host-infested feeding substrate was not affected by acetamiprid in the tested dose range. However, treatment with dimethoate, flupyradifurone and sulfoxaflor resulted in the loss of the females’ preference for host odor. At the lowest doses interfering with olfactory abilities of L. heterotoma in this study (acetamiprid: 0.21 ng, dimethoate: 0.105 ng, flupyradifurone: 2.1 ng and sulfoxaflor: 0.21 ng), ≥ 90% of the wasps survive insecticide treatment. Male pheromone responses and female host finding were also disturbed in those L. heterotoma that had developed in D. melanogaster larvae reared on dimethoate-treated feeding medium at sublethal levels. Hence, doses of this insecticide sufficient to interfere with chemical orientation of L. heterotoma can be taken up by the parasitoid via the food chain.
Leveraging Model Master Files for Long-Acting Injectables
Authors: Gong Yuqing , Hopefl Robert , Li Tonglei , Hooker Andrew C. , Silva Daniela Amaral , Alam Khondoker , Ducharme Murray , Moody Rebecca , Saha Pratik , Babiskin Andrew 
Published: January 2025

Abstract
The U.S. Food and Drug Administration (FDA) and the Center for Research on Complex Generics (CRCG) hosted a public workshop on May 2–3, 2024, titled “Considerations and Potential Regulatory Applications for a Model Master File”. The workshop aimed to discuss the application of the Model Master File (MMF) concept in regulatory submissions that contain model integrated evidence (MIE), improving model sharing, model standardization, regulatory consistency, and regulatory efficiency. On Day 1, there was a session dedicated to MMF applications for long-acting injectables (LAIs). This perspective summarizes presentations, panel discussion, and small group discussion for the potential applications of MMFs in LAI product development, including case studies and potential situations in which MMFs can support regulatory submissions. The scientific presentations discussed the application of MMFs in mechanistic physiologically based pharmacokinetic (PBPK), multiphysics simulation, and population pharmacokinetics (popPK) models, as well as the potential utility of a model-integrated bioequivalence (MI-BE) framework. Additionally, challenges and considerations of implementing MMFs for LAIs were discussed in the panel and small groups. The anticipated benefits of MMFs are recognized among model developers, industries, and regulators.

Graphical Abstract