bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in clinical parameters in cicatrising conjunctivitis secondary to GvHD
Authors: Coco Giulia 
Published: January 2024

Cicatricial conjunctivitis is part of a well‐known complication of graft versus host disease (GVHD) resulting from the tissue fibrosis that affects different body organs. It results from inflammatory reactions determined by recognition of recipient antigens as foreign by donor cells. The main target tissues in ocular GVHD are the conjunctiva and the lacrimal gland, and conjunctival involvement is usually associated with more severe systemic disease. Clinical manifestations of cicatricial conjunctivitis includes conjunctival fibrosis, conjunctival shortening, conjunctival scarring and keratinization, and symblepharon and/or ankyloblepharon. Such scarring may even lead to cicatricial lagophthalmos, ectropion, entropion, and stenosis or closure of the lacrimal puncta. In fact, the degree of palpebral conjunctival changes has been used as a criterion to classify conjunctival involvement in chronic GVHD.Conjunctival epithelial cells and myofibroblasts may have donor origin, though with a very small proportion. These donor‐derived fibroblasts may play a role in the pathogenesis of conjunctival fibrosis. In addition, it has been shown that the ocular surface of patients with chronic GVHD may show epithelial‐mesenchymal transition, in which the epithelium may gain the mesenchymal phenotype and the ability to migrate into the subepithelial stroma, resulting in conjunctival fibrosis.Our group showed that a significant proportion of patients with ocular GHVD had subtarsal fibrosis, that was non evident in non‐GHVD dry eye disease (DED) patients, even with the same degree of clinical severity. Extent of involvement varied from one eye to another; on average, more than a quarter of the visible tarsal area was affected by the fibrosis. Such fibrosis was significantly associated with ocular surface epitheliopathy and conjunctival staining. In contrast, densities of epithelial and stromal immune cells in the conjunctiva were comparable between GVHD and non GVHD DED patients after adjustment for severity of DED. We also showed that spontaneous extrusion of punctal plugs occurs in a majority of ocular GVHD‐associated DED patients within 90 days of plug placement, and this lower retention rate of punctal plugs has been attributed to punctal subepithelial fibrosis.In all patients with ocular GVHD, the eye care provider should evaluate the presence of conjunctival fibrosis and associated ocular surface complications. If present, the therapeutic strategy should attempt to address this scarring process.
Quantitative analysis of crystalline lens and vitreous opacities
Authors: Gupta Ashish , Ruminski Daniel , Villar Alfonso Jimenez , Toledo Raúl Duarte , Gondek Grzegorz , Pierscionek Barbara , Sebag J. , Artal Pablo , Grulkowski Ireneusz 
Published: January 2024

Intraocular light scattering affects the contrast of the image created on the retina thus reducing the vision quality. Although one can consider the ocular components transparent, the microstructural changes (that are associated with aging or other factors) lead to the increase in intraocular light scattering. Therefore, the opacification of ocular structures is associated with vision‐affecting diseases such as corneal dystrophies, crystalline lens cataracts, vitreous floaters etc.Optical coherence tomography (OCT) is a non‐invasive imaging modality enabling generation of micrometre resolution, two‐dimensional (2‐D) cross‐sectional images and three‐dimensional (3‐D) volumetric data presenting internal structure of optically scattering tissues. OCT detects light that is back‐scattered/back‐reflected at the optical in homogeneities within the ocular structures. Due to its high sensitivity, OCT enables detection of ultralow scattered light levels obtained from weakly scattering tissues such as the vitreous body.In this talk, we will demonstrate in vivo enhanced three‐dimensional visualization of vitreous and lens opacities in normal subjects and cataract patients of different ages using a swept source OCT (SS‐OCT) system deployed to the Laboratory of Optics at the University of Murcia, Spain. The instrument operated at the central wavelength of 1050 nm and was optimized to image the anterior segment of the eye. Volumetric images were used to effectively map the opacities and to generate en‐face projection images of opacities.The results revealed the changes in the transparency of the crystalline lens showing lens micro‐ and macro‐scale features related to cataract such as cortical spokes, water clefts and enhanced scattering in the lens nucleus. On the other hand, vitreous imaging with SS‐OCT allowed for visualization of gel vitreous, liquefied lacunae, Berger's space, retrolental laminae and fibrous opacifications.Volumetric OCT data of the lens and retrolental vitreous were used to perform quantitative analysis of light scattering (transparency). We introduced indices describing transparency and optical homogeneity of ocular structures. Later on, we showed that those biomarkers correlate with age. Finally, statistical association between transparency of crystalline lens / vitreous and degradation of visual function was performed.The proposed imaging platform can be a new‐generation ophthalmic diagnostic tool in the fundamental studies as well as for objective clinical evaluation and management of eye diseases.
Anti‐angiogenesis in colorectal cancer therapy
Authors: Yang Zhenni , Zhang Xuqian , Bai Xiaozhe , Xi Xiaonan , Liu Wentian , Zhong Weilong 
Published: January 2024

AbstractThe morbidity of colorectal cancer (CRC) has risen to third place among malignant tumors worldwide. In addition, CRC is a common cancer in China whose incidence increases annually. Angiogenesis plays an important role in the development of tumors because it can bring the nutrients that cancer cells need and take away metabolic waste. Various mechanisms are involved in the formation of neovascularization, and vascular endothelial growth factor is a key mediator. Meanwhile, angiogenesis inhibitors and drug resistance (DR) are challenges to consider when formulating treatment strategies for patients with different conditions. Thus, this review will discuss the molecules, signaling pathways, microenvironment, treatment, and DR of angiogenesis in CRC.
IgE to cross‐reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins
Authors: Potapova Ekaterina , Tripodi Salvatore , Panetta Valentina , Dramburg Stephanie , Bernardini Roberto , Caffarelli Carlo , Casani Antonella , Cervone Rosa , Chini Loredana , Comberiati Pasquale , De Castro Giovanna , del Giudice Michele Miraglia , Dello Iacono Iride , Di Rienzo Businco Andrea , Gallucci Marcella , Giannetti Arianna , Moschese Viviana , Sfika Ifigenia , Varin Elena , Asero Riccardo , Bianchi Annamaria , Calvani Mauro , Frediani Tullio , Macrì Francesco , Maiello Nunzia , Paravati Francesco , Pelosi Umberto , Peroni Diego , Pingitore Giuseppe , Tosca Mariangela , Zicari Anna Maria , Ricci Giampaolo ,   for the Italian Pediatric Allergy Network, Reese Gerald , Grabenhenrich Linus , Icke Katja , Grübl Armin , Müller Christoph , Zepp Fred , Schuster Antje , Wahn Ulrich , Lau Susanne , Keil Thomas , Matricardi Paolo Maria 
Published: January 2024

AbstractBackgroundIgE antibodies to cross‐reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen‐specific IgE tests in vitro. Their prevalence and levels have been so far cross‐sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood.MethodsWe examined CCD with a cross‐sectional approach in 1263 Italian pollen allergic children (Panallergen in Paediatrics, PAN‐PED), as well as with a longitudinal approach in 612 German children (Multicenter Allergy Study, MAS), whose cutaneous and IgE sensitization profile to a broad panel of allergen extracts and molecules was already known. The presence and levels of IgE to CCD were examined in the sera of both cohorts using bromelain (MUXF3) as reagent and a novel chemiluminescence detection system, operating in a solid phase of fluorescently labelled and streptavidin‐coated paramagnetic microparticles (NOVEOS, HYCOR, USA).ResultsIgE to CCD was found in 22% of the Italian pollen allergic children, mainly in association with an IgE response to grass pollen. Children with IgE to CCD had higher total IgE levels and were sensitized to more allergenic molecules of Phleum pratense than those with no IgE to CCD. Among participants of the German MAS birth cohort study, IgE to CCD emerged early in life (even at pre‐school age), with IgE sensitization to group 1 and 4 allergen molecules of grasses, and almost invariably persisted over the full observation period.ConclusionsOur results contribute to dissect the immunological origins, onset, evolution and risk factors of CCD‐sIgE response in childhood, and raise the hypothesis that group 1 and/or 4 allergen molecules of grass pollen are major inducers of these antibodies through an antigen‐specific, T‐B cell cognate interaction.
Interactions between temperature and nutrients determine the population dynamics of primary producers
Authors: Bieg Carling , Vasseur David 
Published: January 2024

AbstractGlobal change is rapidly and fundamentally altering many of the processes regulating the flux of energy throughout ecosystems, and although researchers now understand the effect of temperature on key rates (such as aquatic primary productivity), the theoretical foundation needed to generate forecasts of biomass dynamics and extinction risk remains underdeveloped. We develop new theory that describes the interconnected effects of nutrients and temperature on phytoplankton populations and show that the thermal response of equilibrium biomass (i.e. carrying capacity) always peaks at a lower temperature than for productivity (i.e. growth rate). This mismatch is driven by differences in the thermal responses of growth, death, and per‐capita impact on the nutrient pool, making our results highly general and applicable to widely used population models beyond phytoplankton. We further show that non‐equilibrium dynamics depend on the pace of environmental change relative to underlying vital rates and that populations respond to variable environments differently at high versus low temperatures due to thermal asymmetries.
Q‐switched 1064 nm Nd: YAG laser restores skin photoageing by activating autophagy by TGFβ1 and ITGB1
Authors: Xiang Huiyi , Jia Xiaorong , Duan Xiaoxia , Xu Qi , Zhang Ruiqi , He Yunting , Yang Zhi 
Published: January 2024

AbstractExcessive ultraviolet B ray (UVB) exposure to sunlight results in skin photoageing. Our previous research showed that a Q‐switched 1064 nm Nd: YAG laser can alleviate skin barrier damage through miR‐24‐3p. However, the role of autophagy in the laser treatment of skin photoageing is still unclear. This study aims to investigate whether autophagy is involved in the mechanism of Q‐switched 1064 nm Nd: YAG in the treatment of skin ageing. In vitro, primary human dermal fibroblast (HDF) cells were irradiated with different doses of UVB to establish a cell model of skin photoageing. In vivo, SKH‐1 hairless mice were irradiated with UVB to establish a skin photoageing mouse model and irradiated with laser. The oxidative stress and autophagy levels were detected by western blot, immunofluorescence and flow cytometer. String was used to predict the interaction protein of TGF‐β1, and CO‐IP and GST‐pull down were used to detect the binding relationship between TGFβ1 and ITGB1. In vitro, UVB irradiation reduced HDF cell viability, arrested cell cycle, induced cell senescence and oxidative stress compared with the control group. Laser treatment reversed cell viability, senescence and oxidative stress induced by UVB irradiation and activated autophagy. Autophagy agonists or inhibitors can enhance or attenuate the changes induced by laser treatment, respectively. In vivo, UVB irradiation caused hyperkeratosis, dermis destruction, collagen fibres reduction, increased cellular senescence and activation of oxidative stress in hairless mice. Laser treatment thinned the stratum corneum of skin tissue, increased collagen synthesis and autophagy in the dermis, and decreased the level of oxidative stress. Autophagy agonist rapamycin and autophagy inhibitor 3‐methyladenine (3‐MA) can enhance or attenuate the effects of laser treatment on the skin, respectively. Also, we identified a direct interaction between TGFB1 and ITGB1 and participated in laser irradiation‐activated autophagy, thereby inhibiting UVB‐mediated oxidative stress further reducing skin ageing. Q‐switched 1064 nm Nd: YAG laser treatment inhibited UVB‐induced oxidative stress and restored skin photoageing by activating autophagy, and TGFβ1 and ITGB1 directly incorporated and participated in this process.
Effects of Ion Irradiation on Stage II Fatigue Crack Growth and Plasticity
Authors: Weihrauch Melissa , Patel Maulik , Patterson Eann A. 
Published: January 2024

AbstractFatigue crack growth characteristics of ion irradiated compact tension (CT) specimens were evaluated in the Paris law region. Fatigue crack growth was monitored under tension‐tension loading and the thermoelastic response was measured. Two stages of crack propagation were identified. In the first 300,000 cycles, crack growth rates of irradiated and unirradiated specimens were comparable and plastic zone area was found to be independent of crack length. Beyond 300,000 cycles, irradiated specimens showed a greater crack growth rate; additionally, the plastic zone area increased with crack length. The increase in crack growth rate was attributed to irradiation hardening. The plastic zone area was found to be dependent on the crack path, especially in the initial stages of crack propagation. Local peaks in the value of the area of the plastic zone were found to be associated with greater crack tortuosity and secondary cracks. As a result, decreases in plastic zone area were associated with greater crack growth rates.
Effect of lipase and lipoxygenase on lipid metabolism and the formation of main volatile flavour compounds in fermented fish products: a review
Authors: Ye Qi , Tan Junrui , He Xiaorong , Wang Caixia , Liu Xiaoyu , Li Cheng , Fang Zhengfeng , Chen Hong , Liu Yuntao , Chen Saiyan , Zeng Zhen 
Published: January 2024

SummaryLipid metabolism due to lipid hydrolysis and oxidation considerably contributes to the final product quality of fermented fish products and especially impacts its flavour. Lipase and lipoxygenase (LOX) are key enzymes involved in lipid metabolism. Endogenous lipases (lipase from fish muscle and adipose tissue) and/or exogenous lipases (lipase from microorganisms, the added lipase) catalyse the hydrolysis of lipids, producing numerous free fatty acids. LOX in fish gills and skin tissues plays an important role in lipid oxidation. During the catalysis by LOX, polyunsaturated fatty acids having cis, cis‐1,4‐pentadiene structure are oxidised, finally leading to the generation of flavour precursors or compounds such as alcohols, aldehydes, ketones, esters and acids. The addition of lipase effectively enhances the content of acidic components. Simultaneously, fermented fish products with a start culture capable of producing both lipase and LOX exhibit higher levels of flavour and aroma. In this process, the collaborative action of lipase and LOX generates a rich array of volatile flavour components. This review offers a comprehensive overview of the distinct functions and effects of both endogenous and exogenous lipase, along with LOX, in fermented fish products, as well as their roles in lipid metabolism. The study also explores their effects on the main volatile flavour compounds of fermented fish products. Moreover, the article discusses the prospects of applying lipase and LOX in fermented fish products, highlighting some limitations in current research and offering recommendations for future studies.
Thermochemical data and phase equilibria of halide (Cl−, Br−, I−) containing AFm and hydrotalcite compounds
Authors: Collin Marie , Prentice Dale P. , Geddes Dan , Provis John L. , Ellison Kirk , Balonis Magdalena , Simonetti Dante , Sant Gaurav N. 
Published: January 2024

AbstractLayered double hydroxide (LDH) phases that form during cement hydration can incorporate a variety of interlayer anions in their interlayer positions. Here, a range of phases of general formula [MII(1−x)MIII(x)(OH)2][An−]x/n·zH2O were synthesized, where MII = Mg2+ (hydrotalcite) or Ca2+ (AFm), MIII = Al3+ such that [MII/Al] = 2 (Ca and Mg, atomic units) or 3 (Mg only), and A = Cl−, Br−, or I−. All the synthesized phases were characterized to assess their composition, density, and crystal structure. By approach from undersaturation, the solubility data of these compounds was measured at 5, 25, and 60°C. This thermochemical data was used to successfully model their formation using thermodynamic modeling and to infer the fields of stability of these compounds for conditions of relevance to cementitious systems. It is seen that halide‐containing hydrotalcite phases strongly compete with hydroxide‐containing hydrotalcite, with the latter prevailing at high pH. In contrast, halide‐containing AFm compounds are more stable compared with hydroxide‐containing AFm compositions.
Adapting suicide safety plans for youth with intellectual and developmental disabilities
Authors: Earixson Daniel Q. , Hall Karen C. , Marraccini Marisa E. , Calhoun Casey D. 
Published: January 2024

AbstractIntroductionAlthough risk for suicide appears elevated in individuals with intellectual and developmental disorders (I/DD), few interventions or tools addressing suicide prevention have been adapted for this population. Among evidence‐based interventions for preventing suicide, safety planning interventions are an effective and commonly employed intervention for reducing suicide‐related risk.MethodsBy drawing on Special Education praxis for supporting the learning needs of individuals with I/DD, we provide recommendations for adapting suicide safety planning interventions for youth with I/DD.ResultsSpecific visual, content, teaching, and communication components of the safety plan intervention can be adapted to better meet the needs of youth with I/DD.DiscussionAlthough future research is needed to evaluate these recommendations, these modifications may support clinicians serving youth with I/DD and suicide‐related risk.
Evaluating the influence of primary healthcare nurse practitioners' interventions in home care on hospitalizations and emergency department transfers
Authors: Savard Isabelle , Jabbour Mira , Tchouaket Eric , Gauthier Nathalie , Kilpatrick Kelley 
Published: January 2024

AbstractRationaleHome care allows patients with functional limitations to receive services at home and prevent health decline. Home care can reduce hospitalization and emergency department (ED) transfers. Integrating primary healthcare nurse practitioners (PHCNPs) in home care increases the supply of services, but little is known about their influence on patients' ability to remain at home.Aims and ObjectivesEvaluate the influence of PHCNPs' interventions on hospitalizations and ED transfers in patients receiving care from interprofessional home care teams with PHCNPs.MethodThe retrospective cohort study employed multiple logistic regression and Cox modelling techniques to assess the influence of PHCNP interventions on hospitalizations and ED transfers. Descriptive and bivariate analyses examined sample characteristics and variable associations. Four purposively selected sites in Québec, Canada, were included. Data were collected from electronic health records of all patients (n = 343) receiving home care from these teams.ResultsThe characteristics of the sites, sample, and PHCNP interventions were described. Planned interventions led to a 5.8% decrease in hospitalizations and ED transfers (adjusted odds ratio [OR]: 0.058, p = 0.039), while unplanned interventions resulted in a 1.5‐fold increase in this outcome (adjusted OR: 1.518, p < 0.001). The risk of hospitalization and ED transfers increased by 10.7 times with unplanned interventions (adjusted OR: 10.651, p = 0.002). Furthermore, imaging was associated with a 2‐fold increased risk (adjusted OR: 1.954, p = 0.021), consultations with a 1.8‐fold increased risk (adjusted OR: 1.849, p = 0.034), and laboratory test‐related interventions after 30 or more days reduced the risk by 68.0% (adjusted OR: 0.320, p < 0.001).ConclusionsPHCNPs in interprofessional home care teams show promise in reducing hospitalizations and ED transfers through planned visits. These findings provide valuable insights that can contribute to enhancing home care services for a population with limited access to healthcare and high healthcare needs. Further research is needed in other jurisdictions.
The relationship between hedonic hunger and self‐stigmatisation in terms of weight and self‐esteem in adult people living with obesity
Authors: Çakir Muhammet Ali , Mercan Yeliz , Pancar Nüket , Demircan Ülkü , Pehlivan Merve 
Published: January 2024

AbstractIntroductionThis study aimed to determine the factors influencing the hedonic hunger status of overweight adults and to examine the relationship between hedonic hunger, self‐stigmatisation and self‐esteem in terms of weight.MethodsThis cross‐sectional study was conducted with 353 people living with obesity who applied to the Endocrine and Internal Medicine Clinic in Samsun, Turkey, between June and October 2022. The data were collected using the Personal Information Form, Power of Food Scale (PFS), Weight Self‐Stigmatisation Questionnaire (WSSQ) and Self‐Liking/Self‐Competence Scale (SLSC) through face‐to‐face survey method.ResultsAbout 53.3% of the participants were ≥45 years old, 80.5% were married and 69.1% had previously followed weight loss diet. It was found that those who were aged <45 years, single, those who perceived themselves as overweight, those who had used weight loss diets before and those whose waist‐hip ratio were normal had higher hedonic hunger scores (p < 0.05). A negative and significant correlation was found between PSF‐Tr general dimension scores and SLSC general dimension, whereas a significant and positive correlation was observed between PSF‐Tr general dimension scores and WSSQ general dimension (p < 0.05).ConclusionAs hedonic hunger increased in adults with overweight, self‐esteem decreased, and self‐stigmatisation in terms of weight increased. Effective interventions are needed to cope with the hedonic hunger that contributes to obesity and to prevent the stigma and low self‐esteem experienced by people living with obesity because of their excess weight.