bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and barriers to “Positive Outcomes” from cognitive‐behavioral therapy, according to young people: A thematic synthesis
Authors: Redburn James , Hayes Ben 
Published: February 2024

AbstractObjectiveThis qualitative review sought to explore how young people (YP) conceptualize positive outcomes from cognitive‐behavioral therapy (CBT) and what YP perceive to be the facilitators and barriers to positive outcomes.MethodsA systematic literature search was conducted in June 2021 using six online databases. Studies were included if qualitative data were collected from participants who were aged up to 25, had internalizing mental health difficulties, and had received in‐person CBT from trained practitioners.ResultsNineteen studies were included. The Gough Weight of Evidence framework was used to assess methodological and topical quality and relevance. A thematic synthesis identified 34 conceptualizations of positive outcomes, 57 facilitators, and 49 barriers. Descriptive and analytical themes were identified. In line with the review's pragmatic perspective, the latter were worded as practice recommendations: acknowledge YP's perspectives on outcomes, teach tangible CBT techniques, balance autonomy and support, frame CBT as “upskilling,” explore nuanced barriers to engagement, and consider the power of group dynamics.ConclusionsThis review established the range of YP's views about positive outcomes from CBT, as well as facilitators and barriers to achieving these. Findings should prompt CBT practitioners to reflect and consider how their practice might be shaped through reports from YP as experts by experience.
RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover
Authors: Upadhyay Vishal , Singh Anil Kumar , Sharma Shivani , Sethi Arppita , Srivastava Swati , Chowdhury Sangita , Siddiqui Shumaila , Chattopadhyay Naibedya , Trivedi Arun Kumar 
Published: February 2024

AbstractA few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription factor and thereby regulate bone formation. The regulation of Runx2 expression and function are controlled both at the transcriptional and posttranslational levels. Really interesting new gene (RING) finger ubiquitin ligases of which RNF138 is a member are important players in the ubiquitin‐proteasome system, contributing to the regulation of protein turnover and cellular processes. Here, we demonstrated that RNF138 negatively correlated with Runx2 protein levels in osteopenic ovariectomized rats which implied its role in bone loss. Accordingly, RNF138 overexpression potently inhibited osteoblast differentiation of mesenchyme‐like C3H10T1/2 as well primary rat calvarial osteoblast (RCO) cells in vitro, whereas overexpression of catalytically inactive mutant RNF138Δ18‐58 (lacks RING finger domain) had mild to no effect. Contrarily, RNF138 depletion copiously enhanced endogenous Runx2 levels and augmented osteogenic differentiation of C3H10T1/2 as well as RCOs. Mechanistically, RNF138 physically associates within multiple regions of Runx2 and ubiquitinates it leading to its reduced protein stability in a proteasome‐dependent manner. Moreover, catalytically active RNF138 destabilized Runx2 which resulted in inhibition of its transactivation potential and physiological function of promoting osteoblast differentiation leading to bone loss. These findings underscore the functional involvement of RNF138 in bone formation which is primarily achieved through its modulation of Runx2 by stimulating ubiquitin‐mediated proteasomal degradation. Thus, our findings indicate that RNF138 could be a promising novel target for therapeutic intervention in postmenopausal osteoporosis.
Comparison of antimicrobial efficacy of different disinfectants on the biofilm formation in dental unit water systems using dip slide and conventional methods: A pilot study
Authors: Özmen Pelin , Erdoğan Hilal , Güngördü Aslıhan , Pişkin Bülent , Çobankara Funda Kont , Sütcü Serdar , Şahin Nesrin 
Published: February 2024

AbstractObjectiveBiofilm formation in dental waterlines brings opportunistic infections, especially for immunosuppressive patients. This study aimed to determine biofilm‐forming microorganisms by various methods and investigate disinfectants' effects on biofilm.Materials & MethodsIn the study, samples were obtained from the waterlines of 10–15 aged six dental units, before (0 min.) and after chlorine dioxide (ClO2) and hypochlorous acid (HOCl) treatment (1, 5, 10, 20, and 30 min.), and total colony counts were performed using conventional surface smear method (SSM) and dip slide method (DSM). The Congo red agar and Christensen methods were used to examine the biofilm‐forming properties of the isolates. Monitoring of biofilm presence was also visualized by SEM scanning.ResultsWhen DSM and SSM are compared in all units where ClO2 and HOCl are applied, DSM can detect bacterial growth even during periods of greater exposure to disinfectant application. Although DSM can achieve a value approaching 3% even at the 10th minute in units treated with HOCl; SSM does not show reproduction at the same disinfectant exposure and duration; It was observed that in the units where ClO2 was applied, the growth was no longer observed at the 10th minute with DSM, and SSM, 50% growth in the first minute of the units treated with ClO2 could not be detected in the 5th minute.ConclusionsIt is concluded that it can be advisable to routinely disinfect the dental unit water systems with non‐toxic doses of ClO2 application before patient treatments in clinics and also to perform contamination controls at regular intervals with DSM, which is a sensitive and very practical method.Research highlights
It has been observed that the dip slide method can count bacteria more sensitively than conventional methods in dental water systems without the need for experienced personnel and equipment.
The difference between biofilm formation in water systems before and after disinfectant exposure in SEM examinations is remarkable.
The effects of ClO2 and HOCl on biofilm were investigated and bacterial growth was inhibited in dental units between 5 and 10 minutes with both disinfectants.
A note on the width of sparse random graphs
Authors: Do Tuan Anh , Erde Joshua , Kang Mihyun 
Published: February 2024

AbstractIn this note, we consider the width of a supercritical random graph according to some commonly studied width measures. We give short, direct proofs of results of Lee, Lee and Oum, and of Perarnau and Serra, on the rank‐ and tree‐width of the random graph when for constant. Our proofs avoid the use of black box results on the expansion properties of the giant component in this regime, and so as a further benefit we obtain explicit bounds on the dependence of these results on . Finally, we also consider the width of the random graph in the weakly supercritical regime, where and . In this regime, we determine, up to a constant multiplicative factor, the rank‐ and tree‐width of as a function of and .
A comprehensive investigation of three long‐term precipitation datasets: Which performs better in the Yellow River basin?
Authors: Huang Ruochen , Yong Bin , Huang Fan , Wu Hao , Shen Zhehui , Qian Da 
Published: February 2024

AbstractThe fifth generation European Centre for Medium‐Range Weather Forecasts Reanalysis on global land surface (ERA5‐Land), the Multi‐Source Weighted‐Ensemble Precipitation (MSWEP), and the Climate Hazards Group Infrared Precipitation with Stations (CHIRPS) are three representative precipitation estimates with quasi‐global coverage, high‐resolution and long‐term record. This study concentrates on investigating, for the first time, the long‐term spatiotemporal accuracy and regional applicability of these precipitation estimates at a daily scale in the Yellow River basin (YRB) using 39 complete years of data record (1981–2019), with a special focus on their capability on monitoring the extreme precipitation events with short duration and the continuous heavy precipitation events. Results indicate that MSWEP generally performs better than ERA5‐Land and CHIRPS in almost all seasons and subregions, with the highest Pearson correlation coefficient and critical success index, lowest root mean square error and false alarm ratio. ERA5‐Land presents a severe overestimation of precipitation amount, particularly in the plateau climate region (BIAS = 52.27%), but well reflects its spatial–temporal patterns in the YRB. As for the detecting capability, MSWEP shows the best accuracy in detecting extreme precipitation, particularly in maximum consecutive 5‐day precipitation (RX5day). The MSWEP better represents the spatial distribution of maximum 1‐day precipitation and maximum consecutive 5‐day precipitation in the YRB, but it shows a significant overestimation in zone Southern Qinghai. MSWEP and CHIRPS have better performance of temporal variation consistency in annual precipitation with ground reference than ERA5‐Land, while ERA5‐Land performs well in capturing extreme precipitation temporal variation, especially for continuous heavy precipitation events. This study can provide useful guidance when choosing long‐term precipitation products for hydrometeorological applications and climate‐related studies in the YRB.
Footprint of publication selection bias on meta‐analyses in medicine, environmental sciences, psychology, and economics
Authors: Bartoš František , Maier Maximilian , Wagenmakers Eric‐Jan , Nippold Franziska , Doucouliagos Hristos , Ioannidis John P. A. , Otte Willem M. , Sladekova Martina , Deresssa Teshome K. , Bruns Stephan B. , Fanelli Daniele , Stanley T. D. 
Published: February 2024

AbstractPublication selection bias undermines the systematic accumulation of evidence. To assess the extent of this problem, we survey over 68,000 meta‐analyses containing over 700,000 effect size estimates from medicine (67,386/597,699), environmental sciences (199/12,707), psychology (605/23,563), and economics (327/91,421). Our results indicate that meta‐analyses in economics are the most severely contaminated by publication selection bias, closely followed by meta‐analyses in environmental sciences and psychology, whereas meta‐analyses in medicine are contaminated the least. After adjusting for publication selection bias, the median probability of the presence of an effect decreased from 99.9% to 29.7% in economics, from 98.9% to 55.7% in psychology, from 99.8% to 70.7% in environmental sciences, and from 38.0% to 29.7% in medicine. The median absolute effect sizes (in terms of standardized mean differences) decreased from d = 0.20 to d = 0.07 in economics, from d = 0.37 to d = 0.26 in psychology, from d = 0.62 to d = 0.43 in environmental sciences, and from d = 0.24 to d = 0.13 in medicine.
Self‐Healing Hydrogel Containing Decellularized Liver Matrix and Endothelial Cell‐Covered Hepatocyte Spheroids for Rescue of Injured Hepatocytes
Authors: Chou Xin‐Yu , Cheng Kai‐Yi , Yin Wei‐Rong , Cheng Tzong‐Jih , Chen Richie L. C. , Hsu Shan‐hui , Hou Yung‐Te 
Published: February 2024

AbstractLiver fibrosis occurs in many chronic liver diseases, while severe fibrosis can lead to liver failure. A chitosan‐phenol based self‐healing hydrogel (CP) integrated with decellularized liver matrix (DLM) is proposed in this study as a 3D gel matrix to carry hepatocytes for possible therapy of liver fibrosis. To mimic the physiological liver microenvironment, DLM is extracted from pigs and mixed with CP hydrogel to generate DLM‐CP self‐healing hydrogel. Hepatocyte spheroids coated with endothelial cells (ECs) are fabricated using a customized method and embedded in the hydrogel. Hepatocytes injured by exposure to CCl4‐containing medium are used as the in vitro toxin‐mediated liver fibrosis model, where the EC‐covered hepatocyte spheroids embedded in the hydrogel are co‐cultured with the injured hepatocytes. The urea synthesis of the injured hepatocytes reaches 91% of the normal level after 7 days of co‐culture, indicating that the hepatic function of injured hepatocytes is rescued by the hybrid spheroid‐laden DLM‐CP hydrogel. Moreover, the relative lactate dehydrogenase activity of the injured hepatocytes is decreased 49% by the hybrid spheroid‐laden DLM‐CP hydrogel after 7 days of co‐culture, suggesting reduced damage in the injured hepatocytes. The combination of hepatocyte/EC hybrid spheroids and DLM‐CP hydrogel presents a promising therapeutic strategy for hepatic fibrosis.
How brand gender affects consumer preference for sweet food: The role of the association between gender and taste
Authors: Ding Ying , Liu Yanzheng , Xu Sunxu 
Published: February 2024

AbstractAlthough previous studies have provided some exploratory evidence of the gender‐taste association, empirical evidence on the causal relationships and downstream consequences of such an association in the consumer behavior domain is still lacking. To address this gap, the present research empirically documents the association between gender and taste, and explores the spillover effect of brand gender on consumer preference for sweet food. Across four studies, we demonstrate that feminine and sweet are cognitively associated (Study 1), and accordingly, products launched by a feminine brand are perceived to be sweeter than those launched by a masculine brand (Study 2). Furthermore, a feminine (vs. masculine) brand leads to a higher preference for its sweet (vs. unsweet) products, which is mediated by the perceived congruence between brand gender and product taste (Study 3). Finally, we identify brand type as a moderator, showing that the congruence effect between brand gender and product taste holds for traditional brands but is attenuated for innovative brands (Study 4). Our findings advance the understanding of brand gender association and its impact on consumer behavior and offer meaningful implications for market positioning and communication.
Maternal macronutrient intake effects on offspring macronutrient targets and metabolism
Authors: Freire Therese , Clark Ximonie , Pulpitel Tamara , Bell‐Anderson Kim , Ribeiro Rosilene , Raubenheimer David , Crean Angela J. , Simpson Stephen J. , Solon‐Biet Samantha M. 
Published: February 2024

AbstractObjectiveExposure in utero to maternal diet can program offspring health and susceptibility to disease. Using C57BL6/JArc mice, we investigated how maternal dietary protein to carbohydrate balance influences male and female offspring appetite and metabolic health.MethodsDams were placed on either a low‐protein (LP) or high‐protein (HP) diet. Male and female offspring were placed on a food choice experiment post weaning and were then constrained to either a standard diet or Western diet. Food intake, body weight, and composition were measured, and various metabolic tests were performed at different timepoints.ResultsOffspring from mothers fed HP diets selected a higher protein intake and had increased body weight in early life relative to offspring from LP diet‐fed dams. As predicted by protein leverage theory, higher protein intake targets led to increased food intake when offspring were placed on no‐choice diets, resulting in greater body weight and fat mass. The combination of an HP maternal diet and a Western diet further exacerbated this obesity phenotype and led to long‐term consequences for body composition and metabolism.ConclusionsThis work could help explain the association between elevated protein intake in humans during early life and increased risk of obesity in childhood and later life.
Childhood dental caries and obesity: Opportunities for interdisciplinary approaches to prevention
Authors: Bhoopathi Vinodh , Tripicchio Gina 
Published: February 2024

AbstractDental caries and obesity are prevalent and preventable chronic childhood diseases. Evidence shows a strong connection between these two diseases, with overlapping common risk factors, including diet as a key driver of risk. Dental professionals are well‐positioned to perform nutritional counseling and obesity prevention in dental clinic settings, but training and clinical integration remain key challenges. This paper highlights the potential for leveraging the common risk factor approach (CRFA) framework and its principles to reduce the impact of childhood dental caries and obesity. Strategies and methods are provided to integrate meaningful didactic and clinical training experiences in dental academia, and the need to include effective and evidence‐based nutritional counseling techniques in dental settings is also described. Additionally, the potential for integrating CRFA and engaging health care providers across the spectrum of care, including primary care settings, to reduce the prevalence of these diseases in pediatric populations is highlighted. Finally, the authors propose future directions for multidisciplinary research to advance the scientific knowledge in this area and to inform effective and comprehensive interventions for dental settings.
Dispositional awe negatively predicts corruption via the sense of connectedness
Authors: Jiao Liming , Luo Li 
Published: February 2024

AbstractCorruption is a political and economic issue that has a detrimental impact on social and economic development. This study investigated the predictive effect of dispositional awe on corruption, and the underlying mechanisms from the perspective of connectedness. A sample of 548 (Nfemale = 371) individuals, aged between 16 and 71 years old (M = 21.18, SD = 3.39), was collected. Participants completed scales to measure dispositional awe, the sense of connectedness, corruption, and social desirability. Structural equation modelling and a bootstrap procedure were used to analyze the relationship between the variables. Results showed that dispositional awe negatively predicted corruption, including the tendencies for giving and accepting bribes, and this could be explained by the sense of connectedness, after controlling for the effect of social desirability. The findings highlight the significance of dispositional awe in relation to corruption, enhance our understanding of the underlying mechanisms connecting the two variables, and provide practical implications for the prevention of corruption.
One hundred priority questions for advancing seagrass conservation in Europe
Authors: Nordlund Lina Mtwana , Unsworth Richard K. F. , Wallner‐Hahn Sieglind , Ratnarajah Lavenia , Beca‐Carretero Pedro , Boikova Elmira , Bull James C. , Chefaoui Rosa M. , de los Santos Carmen B. , Gagnon Karine , Garmendia Joxe Mikel , Gizzi Francesca , Govers Laura L. , Gustafsson Camilla , Hineva Elitsa , Infantes Eduardo , Canning‐Clode João , Jahnke Marlene , Kleitou Periklis , Kennedy Hilary , Klayn Stefania , Moller Tiia , Monteiro João , Piñeiro‐Juncal Nerea , Ponis Emanuele , Papathanasiou Vasillis , Poursanidis Dimitris , Pieraccini Riccardo , Serrano Oscar , Sousa Ana. I. , Schäfer Susanne , Rossi Francesca , Storey D. Sebastian , van Katwijk Marieke M. , Wall Dave , Ward Emma A. , Wilkes Robert 
Published: February 2024

Societal Impact StatementSeagrass ecosystems are of fundamental importance to our planet and wellbeing. Seagrasses are marine flowering plants, which engineer ecosystems that provide a multitude of ecosystem services, for example, blue foods and carbon sequestration. Seagrass ecosystems have largely been degraded across much of their global range. There is now increasing interest in the conservation and restoration of these systems, particularly in the context of the climate emergency and the biodiversity crisis. The collation of 100 questions from experts across Europe could, if answered, improve our ability to conserve and restore these systems by facilitating a fundamental shift in the success of such work.SummarySeagrass meadows provide numerous ecosystem services including biodiversity, coastal protection, and carbon sequestration. In Europe, seagrasses can be found in shallow sheltered waters along coastlines, in estuaries & lagoons, and around islands, but their distribution has declined. Factors such as poor water quality, coastal modification, mechanical damage, overfishing, land‐sea interactions, climate change and disease have reduced the coverage of Europe’s seagrasses necessitating their recovery. Research, monitoring and conservation efforts on seagrass ecosystems in Europe are mostly uncoordinated and biased towards certain species and regions, resulting in inadequate delivery of critical information for their management. Here, we aim to identify the 100 priority questions, that if addressed would strongly advance seagrass monitoring, research and conservation in Europe. Using a Delphi method, researchers, practitioners, and policymakers with seagrass experience from across Europe and with diverse seagrass expertise participated in the process that involved the formulation of research questions, a voting process and an online workshop to identify the final list of the 100 questions. The final list of questions covers areas across nine themes: Biodiversity & Ecology; Ecosystem services; Blue carbon; Fishery support; Drivers, Threats, Resilience & Response; Monitoring & Assessment; Conservation & Restoration; Governance, Policy & Management; and Communication. Answering these questions will fill current knowledge gaps and place European seagrass onto a positive trajectory of recovery.
In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients
Authors: Tosca Elena M. , De Carlo Alessandro , Bartolucci Roberta , Fiorentini Francesco , Di Tollo Silvia , Caserini Maurizio , Rocchetti Maurizio , Bettica Paolo , Magni Paolo 
Published: February 2024

AbstractPolycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by excessive levels of platelets (PLT), white blood cells (WBC), and hematocrit (HCT). Givinostat (ITF2357) is a potent histone‐deacetylase inhibitor that showed a good safety/efficacy profile in PV patients during phase I/II studies. A phase III clinical trial had been planned and an adaptive dosing protocol had been proposed where givinostat dose is iteratively adjusted every 28 days (one cycle) based on PLT, WBC, and HCT. As support, a simulation platform to evaluate and refine the proposed givinostat dose adjustment rules was developed. A population pharmacokinetic/pharmacodynamic model predicting the givinostat effects on PLT, WBC, and HCT in PV patients was developed and integrated with a control algorithm implementing the adaptive dosing protocol. Ten in silico trials in ten virtual PV patient populations were simulated 500 times. Considering an eight‐treatment cycle horizon, reducing/increasing the givinostat daily dose by 25 mg/day step resulted in a higher percentage of patients with a complete hematological response (CHR), that is, PLT ≤400 × 109/L, WBC ≤10 × 109/L, and HCT < 45% without phlebotomies in the last three cycles, and a lower percentage of patients with grade II toxicity events compared with 50 mg/day adjustment steps. After the eighth cycle, 85% of patients were predicted to receive a dose ≥100 mg/day and 40.90% (95% prediction interval = [34, 48.05]) to show a CHR. These results were confirmed at the end of 12th, 18th, and 24th cycles, showing a stability of the response between the eighth and 24th cycles.