bluuebunny/crossref_metadata_2025_split huggingface dataset:
The anterior perforated substance (APS) revisited: Commented anatomical and imagenological views
Authors: Fontana Horacio José , Mazzucco Juan , Lescano Sebastián 
Published: November 2023

AbstractIntroductionSince 2002, when we published our article about the anterior perforated substance (APS), the knowledge about the region has grown enormously.ObjectiveTo make a better description of the anatomy of the zone with new dissection material added to the previous, to sustain the anatomical analysis of the MRI employing the SPACE sequence, interacting with our imagenology colleagues. Especially, we aim to identify and topographically localize by MRI the principal structures in APS–substantia innominata (SI).MethodThe presentation follows various steps: (1) location and boundaries of the zone and its neighboring areas; (2) schematic description of the region with simple outlines; (3) cursory revision of the SI and its three systems; (4) serial images of the dissections of the zone and its vessels, illustrated and completed when possible, by MRI images of a voluntary experimental subject (ES).ResultsWith this method, we could expose most of the structures of the region anatomically and imagenologically.DiscussionThe zone can be approached for dissection with magnification and the habitual microsurgical instruments with satisfactory results. We think that fibers in this region should be followed by other anatomical methods in addition to tractography. The principal structures of ventral striopallidum and extended amygdala (EA) can be identified with the SPACE sequence. The amygdala and the basal ganglion of Meynert (BGM) are easily confused because of their similar signal. Anatomical clues can orient the clinician about the different clusters of the BGM in MRI.ConclusionsThe dissection requires a previous knowledge of the zone and a good amount of patience. The APS is a little space where concentrate essential vessels for the telencephalon, “en passage” or perforating, and neural structures of relevant functional import. From anatomical and MRI points of view, both neural and vascular structures follow a harmonious and topographically describable plan. The SPACE MRI sequence has proved to be a useful tool for identifying different structures in this area as the striatopallidal and EA. Anatomical knowledge of the fibers helps in the search of clusters of the basal ganglion.
The role of agri‐food 4.0 in climate‐smart farming for controlling climate change‐related risks: A business perspective analysis
Authors: Kazancoglu Yigit , Lafci Cisem , Kumar Anil , Luthra Sunil , Garza‐Reyes Jose Arturo , Berberoglu Yalcin 
Published: November 2023

AbstractThe impact of climate change, including fires, droughts and storms, on natural resources and agricultural output is increasing. In addition to these problems, resource depletion and greenhouse gas (GHG) emissions, agriculture also contributes to global warming. To reduce the dangers of climate change, farmers are using sustainable practices. This article aims to link agri‐food 4.0 technology with climate‐smart agriculture (CSA) to lessen the two‐way interaction (both affecting and impacted) between the agricultural sector and global warming, as well as dangers related to the agri‐food business. In light of this information, the research methodology of the paper is twofold. Initially, related risks towards climate change and the CSA and agri‐food 4.0 technologies to overcome these risks were determined through a literature review. Then, risks and technologies are evaluated by adopting the TODIM (an acronym in Portuguese for Interactive and Multicriteria Decision Making), which is used for evaluating the criteria set with the related technologies to overcome climate change‐related risks and provide a guiding map for academics and practitioners to eliminate risks associated with these climate change‐related factors. According to the study's findings, the highest‐priority concerns in the agri‐food industries that are connected to climate change include energy consumption, food safety and GHG emissions. Internet of Things (IoT), bio‐innovation and artificial intelligence are thought to be the most promising technological solutions to address these problems.
A review of all‐solid‐state lithium‐selenium batteries
Authors: Guo Baiyu , Zhang Liqiang , Tang Yongfu , Huang Jianyu 
Published: November 2023

AbstractRechargeable lithium‐selenium batteries (LSeBs) are promising candidates for next‐generation energy storage systems due to their exceptional theoretical volumetric energy density (3253 mAh cm−3). However, akin to lithium‐sulfur batteries, the adoption of LSeBs has been hampered by problems such as polyselenides migration in liquid electrolytes, uncontrolled dendrite growth and safety concerns. To overcome these issues, researchers proposed to use the solid‐state electrolytes (SSEs) as a method, which could mitigate the formation of polyselenides. However, practical utilization of the all‐solid‐state Li‐Se batteries (ASSLSeBs) face significant obstacles, including sluggish redox kinetics during Se conversion (Se ↔ Li2Se), inadequate interfacial contact and formation of Li dendrites. Scientists have applied strategies to tackle these challenges. This article offers a timely review of emerging strategies. The article begins by conducting a detailed analysis of the working principles of ASSLSeBs and identifying the critical challenges that hinder practical application. Subsequently, the article presents a comprehensive summary of various strategies aimed at boosting the development of ASSLSeBs, which encompass advancements in Se cathode materials, optimization of SSEs, design of stable Li anodes, and approaches in addressing the interfacial challenge. Finally, the article offers further perspectives about promoting the application of ASSLSeBs. It highlights the need for continued research and development to overcome existing limitations. Overall, by understanding these emerging strategies, researchers could enhance the technology of LSeBs, bringing us closer to the practical realization of high‐energy storage systems.
Targeting colorectal cancer using dietary flavonols
Authors: Dubey Nitin , Dubey Nidhi , Bhadoria Upendra , Shah Kamal , Chauhan Nagendra Singh 
Published: November 2023

AbstractColorectal cancer is among the well‐known forms of cancer and a prominent cause of cancer demises worldwide. In vitro experiments reinforced by animal studies, as well as epidemiological studies of human colorectal cancer propose that the growth of this disease can be moderated by eating aspects. Dietary intake including green vegetables and fruits may result in the reduction of colon cancer chances. The finding suggests that the combinations of dietary nutrients may deliver additive or synergistic effects and might be a powerful method to avoid or eradicate colon cancer beginning and/or development. Flavonols are one of the most widespread dietary nutrients of the polyphenols‐flavonoids and major constituent of Allium and Brassicaceae vegetables. Flavonols present in vegetables of Allium and Brassicaceae family are kaempferol, myricetin, quercetin, and isorhamnetin. These flavonols are claimed to have antiproliferative activity in vivo and in vitro against colorectal cancer. The objective of this review is to summarize the role of flavonols obtained from dietary sources in the prevention and treatment of colorectal cancer.
Outcomes of COVID‐19 in patients with lymphomas participating in registered clinical trials: A real‐world study from China in the Omicron outbreak era
Authors: Sun Peng , Yang Hang , Zhao Baitian , Wang Yu , Nie Man , Huang Kangming , Li Zhiming 
Published: November 2023

AbstractBackgroundThis real‐world study investigated the outcome of COVID‐19 in lymphoma patients participating in registered clinical trials and explored potential risk factors with the outcome of COVID‐19 during the first wave of the Omicron outbreak in China.MethodsOne hundred and ten patients participating in registered clinical trials and diagnosed with COVID‐19 in our center between December 1, 2022, and January 31, 2023, were included.ResultsFour (3.6%) patients were identified as severe COVID‐19 and 2 (1.8%) as critical COVID‐19, respectively. The mortality rate observed was 2.73% for the entire cohort, 33.3% for the severe/critical COVID‐19 group, and 18.8% for the hospitalized group. The 90‐day OS was 98.2% for the entire cohort, 66.7% for the severe/critical COVID‐19 group, and 87.5% for the hospitalized group. Advanced age (≥70 years), comorbidities, and PI3K inhibitor‐containing regimen were significantly associated with the severity of COVID‐19. Patients with indolent B‐cell non‐Hodgkin lymphomas were less likely to be hospitalized for COVID‐19.ConclusionThis study reported similar clinical features of COVID‐19 in our cohort with that of non‐hematological malignancy (HM) patients, while the proportion of severe/critical COVID‐19 and the mortality rate were relatively higher than non‐HM patients. Our findings provided valuable experience to aid clinical researchers with managing lymphoma patients participating in registered clinical trials during the ongoing pandemic of the Omicron variant.
Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies
Authors: Firouzjaei Ali Ahmadizad , Aghaee‐Bakhtiari Seyed Hamid , Tafti Ali , Sharifi Kazem , Abadi Mohammad Hassan Jafari Najaf , Rezaei Samaneh , Mohammadi‐Yeganeh Samira 
Published: November 2023

AbstractColorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of iron‐dependent controlled cell death, in the context of CRC. Curcumin, a natural compound found in turmeric, exhibits anticancer properties. This study explores the effects of curcumin on genes related to ferroptosis (FRGs) in CRC. To gather CRC data, we used the Gene Expression Profiling Interactive Analysis (GEPIA) and Gene Expression Omnibus (GEO) databases, while FRGs were obtained from the FerrDb database and PubMed. We identified 739 CRC differentially expressed genes (DEGs) in CRC and discovered 39 genes that were common genes between FRGs and CRC DEGs. The DEGs related to ferroptosis were enriched with various biological processes and molecular functions, including the regulation of signal transduction and glucose metabolism. Using the Drug Gene Interaction Database (DGIdb), we predicted drugs targeting CRC‐DEGs and identified 17 potential drug targets. Additionally, we identified eight essential proteins related to ferroptosis in CRC, including MYC, IL1B, and SLC1A5. Survival analysis revealed that alterations in gene expression of CDC25A, DDR2, FABP4, IL1B, SNCA, and TFAM were associated with prognosis in CRC patients. In SW480 human CRC cells, treatment with curcumin decreased the expression of MYC, IL1B, and EZH2 mRNA, while simultaneously increasing the expression of SLCA5 and CAV1. The findings of this study suggest that curcumin could regulate FRGs in CRC and have the potential to be utilized as a therapeutic agent for treating CRC.
An increase in intercellular crosstalk and electrotonic coupling between cardiomyocytes and nonmyocytes reshapes the electrical conduction in the metabolic heart characterized by short QT intervals in ECGs
Authors: Billur Deniz , Olgar Yusuf , Durak Aysegul , Yozgat Ayse Hande , Unay Simge , Tuncay Erkan , Turan Belma 
Published: November 2023

AbstractCardiac conduction abnormalities are disorders in metabolic syndrome (MetS), however, their mechanisms are unknown. Although ventricular arrhythmia reflects the changes in QT‐interval of electrocardiograms associated with the changes in cardiomyocyte action potential durations (APDs), recent studies emphasize role of intercellular crosstalk between cardiomyocytes and nonmyocytes via passive (electrotonic)‐conduction. Therefore, considering the possible increase in intercellular interactions of nonmyocytes with cardiomyocytes, we hypothesized an early‐cardiac‐remodeling characterized by short QT‐interval via contributions and modulations of changes by nonmyocytes to the ventricular APs in an early‐stage MetS hearts. Following the feeding of 8‐week‐old rats with a high‐sucrose diet (32%; MetS rats) and validation of insulin resistance, there was a significant increase in heart rate and changes in the electrical characteristics of the hearts, especially a shortening in action potential (AP) duration of the papillary muscles. The patch‐clamp analysis of ventricular cardiomyocytes showed an increase in the Na+‐channel currents while there were decreases in
l‐type Ca2+‐channel (LTCC) currents with unchanged K+‐channel currents. There was an increase in the phosphorylated form of connexin 43 (pCx43), mostly with lateral localization on sarcolemma, while its unphosphorylated form (Cx43) exhibited a high degree of localization within intercalated discs. A high‐level positively‐stained α‐SMA and CD68 cells were prominently localized and distributed in interfibrillar spaces of the heart, implying the possible contributions of myofibroblasts and macrophages to both shortened APDs and abnormal electrical conduction in MetS hearts. Our data propose a previously unrecognized pathway for SQT induction in the heart. This pathway includes not only the contribution of short ventricular‐APDs via ionic mechanisms but also increasing contributions of the electrotonic‐cardiomyocyte depolarization, spontaneous electrical activity‐associated fast heterogeneous impulse conduction in the heart via increased interactions and relocations between cardiomyocytes and nonmyocytes, which may be an explanation for the development of an SQT in early‐cardiac‐remodeling.
Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature
Authors: Wang Yihan , Chen Yan , Fu Yantao 
Published: November 2023

Key Clinical MessageParathyroid lipoadenoma is a rare type of parathyroid adenoma, described as a single parathyroid adenoma with more than 50% fat on histologic examination and an unknown etiology, which is one of the rare causes of primary hyperparathyroidism. The difficulty of parathyroid lipoadenoma is mainly diagnosed by preoperative imaging localization. We hope to arouse attention to the parathyroid adenoma which is difficult to locate through our case report. The patient was a middle‐aged male with a body mass index of 38.4 kg/m2 who admitted to our hospital with a 40‐day history of an untreated thyroid nodule. We incidentally discovered parathyroid lipoadenoma in his thyroid surgery. His prognosis was good, and there were no signs of recurrence at his 12‐month follow‐up appointment. We believe that parathyroid lipoadenoma needs to rely on paraffin pathology to make a final diagnosis. This case report serves as a reminder that parathyroid lipoadenomas are also possible in patients who do not have primary hyperparathyroidism preoperatively and who have negative imaging. Clinicians must carefully examine the adipose tissue for the presence of parathyroid lipoadenomas during thyroid surgery to avoid postoperative hypoparathyroidism and persistent hypocalcaemia.
Postoperative wound infection by nontuberculous mycobacteria; case series in Dhaka Medical College Hospital of Bangladesh
Authors: Halder Kakali , Tanni Nusrat Noor , Kabir Rubaiya Binte , Nesa Maherun , Rahman Md. Faizur , Zaman Rizwana , Habib Farjana Binte , Tania Noor‐E‐Jannat , Asaduzzaman Md. , Haque Azmeri , Chowdhury Akteruzzaman , Sarker Avizit , Akter Nadira , Chowdhury Mahbuba , Shahid Sazzad Bin , Shamsuzzaman S. M. 
Published: November 2023

Key Clinical MessageThe incidence of nontuberculous mycobacterial (NTM) infections after operations is increasing in Bangladesh but data regarding clinical presentation, diagnosis, treatment, and prognosis after treatment are lacking. In this case series, three patients having persistent serous discharge from incision wound after operation were studied. Discharge from wounds were collected, wet film microscopy was performed for pus cells and fungus, Gram stain, Ziehl‐Neelsen (ZN) stain, culture in routine culture media and Lowenstein‐Jensen (LJ) media, Xene‐Xpert for mycobacterium tuberculosis (MTB), polymerase chain reaction (PCR) for NTM were done. NTM‐positive patients were treated initially for 6 weeks with four drugs regimen (clarithromycin 500 mg 12 hourly, ciprofloxacin 500 mg 12 hourly, linezolid 400 mg 12 hourly, and amikacin 500 mg 12 hourly), followed by 5 months with three drugs regimen (clarithromycin 500 mg 12 hourly, ciprofloxacin 500 mg 12 hourly, and linezolid 400 mg 12 hourly) as a maintenance dose. Cessation of discharge occurred within 3–4 weeks after starting treatment, and the wounds were healed.
Recent Progress and Challenges in Perylene Small Molecules, Assemblies and Composites for Photocatalytic Hydrogen Evolution
Authors: Kumari Anita , Sengupta Sanchita 
Published: November 2023

AbstractPerylene diimide (PDI) derivatives are among the best‐known n‐type organic semiconductors because of their unique photophysical and chemical characteristics. In recent years, significant progress has been made in the development of various PDI/composites and their self‐assembled structures for photocatalytic hydrogen (H2) evolution. However, the slow transport of photogenerated charge carriers, rapid charge recombination, limited catalytic activity, and instability of these materials still pose difficulties for their practical use. In order to address these problems, extensive studies have been conducted on structural modifications, molecular design, and synthesis techniques to control the morphology of self‐assembled PDI structures and create new and effective photocatalysts. In this context, perylene based small molecules, their composites with TiO2 and g‐C3N4, self‐assembled perylene derivatives have been designed and their roles as heterogenous photocatalysts for H2 evolution have been investigated thoroughly in literature. In this review, the developments of PDI‐based photocatalysts for H2 evolution are outlined under four different categories. Self‐assembled PDI nanostructures have made the most advancements among all the categories, with highest hydrogen evolution rate (HER) of 61.49 mmol g−1 h−1 while composites composed of perylene derivatives and g‐C3N4 exhibited the second highest rate of hydrogen evolution (17.7 mmol g−1 h−1). This review is intended to give researchers a better understanding and guidelines for designing PDI‐based and other chromophore‐based materials for efficient H2 evolution and their further exploration for future improvement in H2 evolution efficiencies.
Strategies to Develop Electrocatalytically Active Perovskite Oxide Nanosheets
Authors: Majee Rahul , Bhattacharyya Sayan 
Published: November 2023

AbstractIn the research field of alternative energy, perovskite oxides remain one of the prominent classes of electrocatalysts because of their outstanding compositional and chemical versatility, tuneable catalytically active centers, and structural robustness leading to operational stability. However, their routine high‐temperature synthesis curbs the available active sites, and consequently, there is an ongoing urge to mend the perovskite oxides towards dimensionally reduced forms which can endow maximum surface‐active sites to accelerate the redox processes. Despite the burgeoning interests, research in this field barely began in the last decade. This review highlights some of the relevant literature findings, and rationalizes the limitations, and benefits of developing two‐dimensional (2D) nanostructures of electrocatalytically active perovskite oxides. Furthermore, the roadblocks of the current approaches for wide‐stretched adaptability and standing gaps to counter such bottlenecks are discussed.
Oligodentate Aminotriazole Ligands for CuAAC and Copper‐Mediated Monooxygenation of Phenols: Influence of Denticity, Chain Length and N‐Alkylation on Catalytic Activity
Authors: Koch Alexander , Engesser Tobias A. , Näther C. , Tuczek Felix 
Published: November 2023

AbstractCopper complexes supported by a series of ligands containing different N‐donor groups were prepared, and the influence of the ligand design on the catalytic activity towards (i) the conversion of monophenols to o‐quinones and (ii) the CuAAC reaction was investigated. Increasing the number of methyltriazole moieties attached to an amine from one (TTA) over two (BTTA) to three (TTTA) decreases the catalytic mono‐phenolase activity of derived Cu complexes. By contrast, replacing the methylene group between the apical and the outer N‐donors of TTA with an ethylene bridge in TTEA increases the activity whereas alkylation of the amino group (dmTTEA, prlTTEA) has no positive effect on the catalytic activity. When employing the complexes in the CuAAC reaction, opposite trends in catalytic activity are observed. The results are interpreted in the context of the respective mechanistic pathways.
Regioselectivity in Carbonylation of Pentenoic Acid to Synthesize Cyclic Anhydrides
Authors: Ramakrishnan Ashok , Bouwman Elisabeth 
Published: November 2023

AbstractPentenoic acids (PEA) obtained from biomass‐derived γ‐valerolactone (GVL) can serve as a platform for sustainable and atom‐economic synthesis of adipic acid and its derivatives. Herein, the results are reported on the cyclocarbonylation reaction of PEA to synthesize five‐ (5 a), six‐ (6 a), or seven‐membered (7 a) cyclic anhydrides, with the aim to drive the reaction towards 7 a, a potential intermediate to caprolactam. Carbonylation of 4‐PEA yielded up to 73 % cyclic anhydrides, 7 a and 6 a in ratio 79 : 21. However, from 3‐PEA the same palladium‐based catalytic system in the absence of strong acids yielded 61 % 6 a and 5 a (41 : 59), indicating the inability of the catalyst to force isomerization. Isomerization, which is essential to obtain 7 a from a mixture of PEA isomers derived from GVL, does occur in presence of strong acids; however, this led predominantly to formation of smaller rings (6 a and 5 a) from 4‐PEA. Catalytic systems containing ligands with bulky tert‐butyl substituents yielded 6 a and trace amounts of 7 a. Although 7 a can be obtained from 4‐PEA in reasonable selectivity, there still remains a challenge to selectively synthesize 7 a from a mixture of PEA isomers.
A Primer on 2D Descriptors in Selectivity Modeling for Asymmetric Catalysis
Authors: Sidorov Pavel , Tsuji Nobuya 
Published: November 2023

AbstractMachine learning has permeated all fields of research, including chemistry, and is now an integral part of the design of novel compounds with desired properties. In the field of asymmetric catalysis, the preference still lies with models based on a physical understanding of the catalysis phenomenon and the electronic and steric properties of catalysts. However, such models require quantum chemical calculations and are thus limited by their computational cost. Here, we highlight the recent advances in modeling catalyst selectivity by using the 2D structures of catalysts and substrates. While these have a less explicit mechanistic connection to the modeled property, 2D descriptors, such as topological indices, molecular fingerprints, and fragments, offer the tremendous advantages of low cost and high speed of calculations. This makes them optimal for the in‐silico screening of large amounts of data. We provide an overview of common quantitative structure‐property relationship workflow, model building and validation techniques, applications of these methodologies in asymmetric catalysis design, and an outlook on improving the understanding of 2D‐based models.