bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective assessment of neoadjuvant camrelizumab combined with induction chemotherapy: efficacy in laryngeal preservation for advanced hypopharyngeal and laryngeal squamous cell carcinoma
Authors: Peng Jin , Luo Guangfeng , Yu Yongchao , Ning Kang , Liu Xuekui 
Published: February 2024

Abstract
Background
Hypopharyngeal and laryngeal squamous cell carcinoma (SCC) account for 25–30% of head and neck SCC. Total laryngectomy, while effective, compromises the quality of life. Immune checkpoint inhibitors such as Camrelizumab offer potential in laryngeal preservation. The study investigated Camrelizumab combined with TP regimen as a neoadjuvant therapy for laryngeal preservation in advanced hypopharyngeal and laryngeal SCC.

Methods
A retrospective study was conducted at Sun Yat-sen University Cancer Center on patients diagnosed with locally advanced SCC of the hypopharynx and larynx from October 1, 2019, to October 25, 2022. The efficacy of a first-line treatment combining Camrelizumab (200 mg) and TP regimen (Albumin-bound paclitaxel at 260 mg/m2 and Cisplatin at 60 mg/m2) was evaluated using RECIST 1.1 criteria. Outcomes included overall survival (OS), progression-free survival (PFS), laryngectomy-free survival (LFS), and response rates.

Results
Of the 71 included patients, the median age was 60.7 years. Post the first-line treatment, 90.1% demonstrated an overall response. The one-year and two-year OS rates were 91.5% and 84.3%, respectively. One-year and two-year PFS rates were 92.9% and 83.9%, respectively, with LFS at 85.6% and 73.2%. The initial T4 stage as significantly associated with reduced OS and LFS. Skin reaction was the predominant adverse event.

Conclusion
The Camrelizumab-TP regimen demonstrated promising results for advanced hypopharyngeal/laryngeal SCC patients, exhibiting high response rates, OS, and LFS, positioning it as a potential primary option for laryngeal preservation. Further comprehensive, randomized controlled studies are imperative to validate these initial observations and elucidate the regimen's full clinical efficacy in optimizing laryngeal outcomes.
Synthesis of a novel green biopolymer-based composites beads for removal of methylene blue from aquatic medium: isotherm, thermodynamic and kinetic investigation
Authors: Parlayici Şerife , Aras Aslı 
Published: February 2024

AbstractThe increase in the world population and the decrease in clean water resources increase people's interest in water purification technologies. Many industries, such as the textile industry, leather industry, cosmetics and food industry, color their products with substances such as dyes and pigments. In this study, a cheap, useful, innovative, environmentally friendly, and sustainable adsorbent was developed for the removal of Methylene Blue (MB), one of the dyes that is harmful to the environment. In fruit tree cultivation, in addition to the product, very high amounts of by-products/waste (branches, bark, leaves, fruit seeds, fruit shells, etc.) are produced. In this direction, walnut tree and olive tree wastes were immobilized with chitosan, made magnetic (m-WCH and m-OCH), and the adsorption of MB on the developed adsorbents was examined in a batch system. Characterization of the synthesized biocomposite adsorbents was performed by FT-IR, SEM, EDX and XRD analyzes. It has been thoroughly described how the pH solution of the MB dye compares to the pHPZC of the adsorbent surface. The pHPZC values for m-WCH and m-OCH were 5.2 and 5.5 respectively. MB adsorption of biocomposites depends on the pH of the environment (3–8), amount of adsorbent (2–10 gL−1), contact time (5–360 min), temperature (25–55 °C) and initial dye concentration (10–250 ppm) was examined as a function. The obtained data were evaluated with kinetic and isotherm models. Using adsorption equilibrium data obtained from MB adsorption studies using m-WCH and m-OCH biocomposite adsorbents, their suitability to Langmuir, Freundlich, Stachard, Dubinin–Radushkevich and Temkin models was examined. The empirical data of MB adsorption by m-WCH and m-OCH showed agreement with the Langmuir isotherm model. The maximum adsorption capacity for MB by m-WCH and m-OCH was estimated to be 85.47 mg g−1 and 53.48 mg g−1, respectively. The result showed that a higher adsorption selectivity on m-WCH compares to m-OCH. Among the kinetic models applied, the pseudo-second-order kinetic model was identified with the highest regression coefficients. In the light of these results, it was determined that there are new promising adsorbents of natural origin, with higher adsorption capacity, lower cost, and alternatives to commercially used adsorbents in the removal of MB from aqueous media.
Graphical abstract
The 2023 Türkiye-Syria earthquakes: analysis of pediatric victims with crush syndrome and acute kidney Injury
Authors: Döven Serra Sürmeli , Tezol Özlem , Yeşil Edanur , Durak Fatma , Mısırlıoğlu Merve , Alakaya Mehmet , Karahan Feryal , Kıllı İsa , Akça Mehtap , Erdoğan Semra , Can Mevlüt , Delibaş Ali 
Published: February 2024

Abstract
Background
On February 6th, 2023, two consecutive earthquakes struck southeastern Türkiye with magnitudes of 7.7 and 7.6, respectively. This study aimed to analyze the clinical and laboratory findings, as well as management of pediatric victims with Crush Syndrome (CS) and Acute Kidney Injury (AKI).

Methods
The study included pediatric earthquake victims who were presented to Mersin University Hospital. Clinical and laboratory characteristics of the patients were collected retrospectively.

Results
Among 649 patients, Crush injury (CI), CS and AKI was observed in 157, 59, and 17 patients, respectively. White blood cell count (12,870 [IQR: 9910–18700] vs. 10,545 [IQR: 8355–14057] /µL, P < 0.001), C-reactive protein (51.27 [IQR: 14.80–88.78] vs. 4.59 [1.04–18.25] mg/L, P < 0.001) and myoglobin levels (443.00 [IQR: 198.5–1759.35] vs. 17 [11.8–30.43] ng/ml) were higher in patients with CS, while their sodium (IQR: 134 [131–137] vs. 136 [134–138] mEq/L, P < 0.001) levels were lower compared to non-CS patients. An increase in myoglobin levels was identified as an independent risk factor for developing CS (OR = 1.017 [1.006–1.027]). Intravenous fluid replacement was administered to the patients with CS at a dose of 4000 cc/m2/day. Hypokalemia was observed in 51.9% of the CS patients on the third day. All patients with AKI showed improvement and no deaths were reported.

Conclusions
Hyponatremia and increase in inflammation markers associated with CS may be observed. An increase in myoglobin levels was identified as a risk factor for CS. Hypokalemia may be seen as a complication of vigorous fluid therapy during hospitalization.

Graphical abstract
Hybrid 2D/3D-quantitative structure–activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides
Authors: Yan Qingguo , Wang Fangfang , Zhou Bo , Lin Xiangna 
Published: February 2024

AbstractAntimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechanism involved in crossing the cell membrane without inducing severe membrane collapse, then interacting with cytoplasmic target-nucleic acid, and exerting antibacterial activity by interfacing the transmission of genetic information of pathogenic microorganisms. However, the relationship between the antibacterial activities and peptide structures was still unclear. Therefore, in the present work, a series of AMPs with a sequence of 20 amino acids was extracted from DBAASP database, then, quantitative structure–activity relationship (QSAR) methods were conducted on these peptides. In addition, novel antimicrobial peptides with stronger antimicrobial activities were designed according to the information originated from the constructed models. Hence, the outcome of this study would lay a solid foundation for the in-silico design and exploration of novel antibacterial peptides with improved activity activities.
Sustainable farm work in agroecology: how do systemic factors matter?
Authors: Volken Sandra , Bottazzi Patrick 
Published: February 2024

AbstractAgroecological farming is widely considered to reconcile improved working and living conditions of farmers while promoting social, economic, and ecological sustainability. However, most existing research primarily focuses on relatively narrow trade-offs between workload, economic and ecological outcomes at farm level and overlooks the critical role of contextual factors. This article conducts a critical literature review on the complex nature of agroecological farm work and proposes the holistic concept of sustainable farm work (SFW) in agroecology together with a heuristic evaluation framework. The latter was applied to ten case studies to test its relevance, affirming positive outcomes of agroecology on SFW, such as improved food sovereignty, biodiversity conservation, and social inclusiveness, but also showing trade-offs, including increased workload and potential yield reductions. Further, results show that contextual factors, such as policy support, market regulation, and access to resources, heavily influence the impact of agroecological practices on SFW. This article strongly argues for the importance of a holistic understanding of SFW and its contextualization within multiple socio-ecological system levels. The proposed framework establishes clear relationships between agroecology and SFW. An explicit recognition of these multidimensional relationships is essential for maximizing positive outcomes of agroecology in different contexts and fostering SFW. On a theoretical level, this research concludes that, from a holistic perspective, work is an entry point to studying the potential of agroecology to drive a sustainable agroecological transition in economic, social, and ecological terms.
Sequential composition of propositional logic programs
Authors: Antić Christian 
Published: February 2024

AbstractThis paper introduces and studies the sequential composition and decomposition of propositional logic programs. We show that acyclic programs can be decomposed into single-rule programs and provide a general decomposition result for arbitrary programs. We show that the immediate consequence operator of a program can be represented via composition which allows us to compute its least model without any explicit reference to operators. This bridges the conceptual gap between the syntax and semantics of a propositional logic program in a mathematically satisfactory way.
Mixed-Method, Multilevel Clustered-Randomized Control Trial for Menstrual Health Disparities
Authors: Houghton Lauren C. , Adkins-Jackson Paris B. 
Published: February 2024

AbstractMenstrual cycle characteristics are largely considered unmodifiable reproductive factors, a framing that prevents exploration of the ways structural factors interfere with menstrual health. Given the role of structural factors like healthy food and healthcare access on reproductive health and the grave need for structural interventions to known reproductive health disparities that disproportionately target cisgender women racialized as Black, it is imperative that science begin to examine how structural factors influence menstrual health. To explore such research, we employ critical race theory and intersectionality to illustrate what a structural intervention to improve menstrual cycle health could look like. Centering those with the greatest need, persons racialized as Black and/or LatinX living in food and healthcare deserts in Northern Manhattan, our illustrative sample includes four groups of persons who menstruate (e.g., cisgender girls and women) that are pre-menarche, pre-parous, postpartum, or perimenopausal. We describe a hypothetical, multilevel clustered-randomized control trial (cRCT) that provides psychoeducation on racism-related trauma and free delivered groceries to both treatment and control groups, while randomizing 30 clusters of housing associations to receive either sexual health clinics at their housing association or free vouchers for healthcare. We embed mixed methods (diaries, interviews, surveys, mobile apps, observation) into the design to evaluate the effectiveness of the 1-year intervention, in addition to determining the impact on participants through their perspectives. Through this illustration, we provide a novel example of how structural interventions can apply mixed methods to evaluate effectiveness while delivering services to populations impacted by multiple structural factors. We demonstrate how qualitative and quantitative approaches can be paired in clustered RCTs and how a living logic model can empirically incorporate the population perspective into more effective interventions. Lastly, we reveal how sensitive menstrual health is to structural factors and how upstream improvements will trickle down to potentially reduce health disparities in reproductive health.
A Discussion of Implausible Total Solar-Irradiance Variations Since 1700
Authors: Chatzistergos Theodosios 
Published: February 2024

AbstractThe Sun plays a role in influencing Earth’s climate, making it important to have accurate information about variations in the Sun’s radiative output. Models are used to recover total solar-irradiance (TSI) variations in the past when direct space-based measurements are not available. One of the most cryptic such TSI reconstructions is the one by Hoyt and Schatten (J. Geophys. Res. 98, 18, 1993, HS93). The rather vague description of the model methodology, the arbitrary selection of solar indices it employs, and the short overlap between the HS93 series and directly measured TSI values has hindered any evaluation of the performance of this model to this day. Here, we aim at rectifying this by updating the HS93 model with new input data. In this way we are also contributing in the discussion on the possible long-term changes in solar irradiance.We find that the analysis by HS93 included a number of erroneous processing steps that led to an artificial increasing trend towards the end of the reconstructed TSI series as well as shifting the peak of the TSI in the mid-twentieth century back in time by about 11 years. Furthermore, by using direct measurements of the TSI we determined that the free parameter of the model, the magnitude of variations (here defined as percentage variations of the difference between the maximum to minimum values), is optimal when it is minimised (being ≤0.05%). This is in stark contrast to the high magnitude of variations, of 0.25%, that was imposed by HS93. However, our result is consistent with more recent estimates, such as those from the Spectral And Total Irradiance REconstruction (SATIRE) model and Naval Research Laboratory TSI (NRLTSI), which were used by the Intergovernmental Panel on Climate Change (IPCC). Overall, we find that the previously reported agreement of the HS93 TSI series to temperature on Earth was purely due to improper analysis and artefacts of the processing.
An accuracy characterisation of approximate coherence
Authors: Molinari Giacomo 
Published: February 2024

AbstractAccuracy-first epistemologists argue that rational agents have probabilistically coherent credences. But why should we care, given that we can’t help being incoherent? A common answer: probabilistic coherence is an ideal to be approximated as best one can. De Bona (in: Philos Sci 84(2), 189–213, 2017) and Staffel (in: Unsettled thoughts: a theory of degrees of rationality, Oxford University Press, 2019) show how accuracy-firsters can spell out this answer by adopting an appropriate notion of approximate coherence. In this essay, I argue that De Bona and Staffel’s proposal is not entirely satisfactory, because it does not show whether, or why, it’s generally better to be more rather than less approximately coherent from an accuracy-first perspective. To address this point, I give a characterisation of their notion of approximate coherence in terms of accuracy. This shows that accuracy-firsters should maintain that more approximately coherent credences are better than less approximately coherent ones if and only if they accept that it’s better to miss out on less rather than more guaranteed accuracy.
The Effect of Discounting on the Formulation of an Aquifer Management Policy Based on Groundwater Trading
Authors: Tsiarapas Athanasios , Mallios Zisis 
Published: February 2024

AbstractOptimal groundwater management is a necessary condition for achieving the objective of sustainable development, which is directly linked to issues of intergenerational equity. Thus, groundwater management policy shaping has to consider such issues, in particular through the implementation of appropriate discounting methods. The existing literature in the field of groundwater management focuses on a single discount function (DF), the exponential one, without considering the impact of different DFs on the results obtained. At the same time, tradable water rights (TWR) systems have been suggested as policy instruments for more efficient and sustainable water use. This paper focuses on the impact that different DFs have on the formulation of groundwater management policies based on TWR. To this end, a dynamic model is formulated, which concerns groundwater pumping from an aquifer by two groups of users participating in a TWR system and four different DFs are considered to calculate the present value of social welfare: no discounting, exponential, hyperbolic and Gamma discounting. The results of simulations based on data for an aquifer in Northern Greece show that there is a high sensitivity of the results to the DF, which has a direct effect on social welfare from groundwater consumption, aquifer’s hydrological behavior and TWR system intertemporal economic efficiency.
Development of a “Rapid-Crypto Colorimetric LAMP Test” to Detect Cryptosporidiosis in Feces of Newborns Calves
Authors: Karakavuk Muhammet , Can Hüseyin , Can Şengül , Karakavuk Tuğba , Döşkaya Mert , Değirmenci Döşkaya Aysu 
Published: February 2024

Abstract
Background
Cryptosporidiosis is a disease that causes major intestinal damage in humans and animals. The causative agents of the disease are Cryptosporidium species. In newborn calves, diarrhea can lead to death, resulting in significant economic losses for the farms. Therefore, accurate, rapid, and cost-effective diagnosis of the disease is very important.

Material and methods
In this study, a novel colorimetric loop-mediated isothermal amplification (LAMP) test named “Rapid-Crypto Colorimetric LAMP test” targeting Cryptosporidium spp. 18S rRNA gene was developed to detect cryptosporidiosis in the feces of newborn calves. The analytical sensitivity of the test was determined by plasmid controls. Clinical sensitivity was determined using the feces of 127 calves collected from farms in İzmir and Manisa provinces. All of the samples were also investigated with Real-Time PCR targeting the Cryptosporidium spp. COWP gene. Cross-reactivity was tested using the DNA of other parasites and bacteria.

Results
According to the results, the analytical sensitivity of the “Rapid-Crypto Colorimetric LAMP test” was found as 1 copy plasmid/reaction. When the results were compared with the Real-Time PCR test, the sensitivity of the “Rapid-Crypto Colorimetric LAMP test” was 100% and the specificity was 97.4%. The test did not cross-react with other parasites and bacteria.

Conclusion
The “Rapid-Crypto Colorimetric LAMP test” developed in this study provides an advantage in the diagnosis of Cryptosporidium spp. in calf stool samples since it can be applied in basic laboratories or in the field, does not require experienced personnel, and has high sensitivity. Moreover, diagnosis can be made with the naked eye without using any device.
Home-based exercise interventions’ impact on breast cancer survivors’ functional performance: a systematic review
Authors: Ramos Pedro G.F. , Júdice Pedro B. , Nobre Inês , Carraça Eliana V. 
Published: February 2024

Abstract
Introduction
Home-based exercise (HBE) programs can be a feasible strategy to enhance functional performance and promote physical activity (PA) in breast cancer survivors. A deeper analysis of the effects of HBE interventions, structured by HBE program type and treatment phase, is needed. This systematic review aimed to synthesize the evidence on HBE interventions’ impact on breast cancer survivors’ functional performance, PA levels, and program adherence rates, according to HBE intervention type and treatment phase.

Methods
A comprehensive search of peer-reviewed articles reporting HBE interventions’ effects on the outcomes of interest was performed in Pubmed, Google Scholar, EBSCO, Web of Science, Science Direct, and B-ON until January 15th, 2024. Data were synthesized according to Denton’s domains to classify HBE interventions (prescription: structured vs. unstructured; Delivery method: supervised vs. facilitated vs. unsupervised) and treatment phase. Methodological quality appraisal was performed using the Effective Public Health Practice Project tool.

Results
Twenty-six studies were included. Most studies conducted structured/facilitated interventions and reported positive effects on functional performance (particularly aerobic capacity), increases in PA levels, and high adherence rates (> 70%) during and post-treatment.

Conclusion
HBE interventions may be feasible to improve functional performance and promote physical activity among breast cancer survivors. Further studies are needed to confirm which HBE intervention type is more appropriate for each treatment phase. More evidence applying HBE interventions with different designs is required to allow the drawing of more solid conclusions. Studies exploring the effects of HBE interventions on the pre-treatment phase are needed.
Self-care advice for patients after surgery for oesophageal cancer — a mixed-methods systematic review
Authors: Schandl Anna , Färnqvist Kenneth , Mälberg Kalle , Nielsen Sandra , Lagergren Pernilla 
Published: February 2024

Abstract
Purpose
The aim of the literature review was to identify and synthesise research on self-care advice for oesophageal cancer survivors.

Methods
A mixed-methods systematic review and synthesis of existing literature on the topic. Five databases were searched for studies providing information on self-care advice for survivorship after oesophageal cancer surgery, in English, with no time filter. The Critical Appraisal Skills Program was used to assess the risk of bias. Data were presented by textual descriptions and grouping of data.

Results
Among the 13 studies included in the review, five pieces of self-care advice were identified; reconstructing eating habits, bed-head elevation, health-promoting advice, monitoring symptoms and body functions, and involving family and friends. The self-care advice was experienced to be hard work, but worth the effort. They also provided reassurance and an increased understanding of bodily changes and social consequences of the disease and treatment.

Conclusions
There are is little evidence-based self-care advice for oesophageal cancer survivors. However, the existing self-care advice was appreciated and contributed to an increased understanding of the situation. Comprehensible and easy-to-follow recommendations should be provided to all oesophageal cancer survivors.

Implications for Cancer Survivors
Evidence-based self-care advice helpful for the individual oesophageal cancer survivor may be imperative to cope with the consequences of oesophagectomy after hospital discharge.