bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD5‐negative chronic lymphocytic leukemia with indolent clinical course and autoimmune thrombocytopenia, successfully treated with rituximab
Authors: Okamoto Masashi , Nakano Sonoko , Namura Kyoko , Yamada Noriko , Uchida Ryo , Fuchida Shin‐ichi , Okano Akira , Ochiai Naoya , Shimazaki Chihiro 
Published: November 2004

AbstractA 59‐year‐old male with lymphocytosis and thrombocytopenia was asymptomatic without lymphadenopathy or hepatosplenomegaly over 10 years. He was admitted to our hospital because his thrombocytopenia had worsened. The clonal lymphocytes appeared as regular small mature lymphocytes on blood films, and bone marrow biopsy showed diffuse infiltration of mature lymphocytes. However, megakaryocytes also presented. The immunophenotypic analysis by flow cytometry revealed that the lymphocytes were positive for CD19, CD20, CD22, and surface membrane immunoglobulin (SmIg) M and D‐lambda and were negative for CD5, CD10, CD11c, CD23, and other lineage markers. Expression levels of CD20 and SmIg were strong. The markers were consistent with CD5− CLL with autoimmune thrombocytopenia. He received rituximab, and a rapid decrease of lymphocytes with concomitant increase of platelets was observed. A few cases of CD5− CLL with a stable clinical course have been reported, thought to be B lymphocytosis of undetermined significance (MLUS). This is the first report of CD5− CLL with indolent clinical course associated with autoimmune thrombocytopenia, successfully treated with rituximab. Am. J. Hematol. 77:413–415, 2004. © 2004 Wiley‐Liss, Inc.
Pericardial effusion: A rare presentation of adult T‐cell leukemia/lymphoma
Authors: Chaves Fernando P. , Quillen Karen , Xu Dongsheng 
Published: November 2004

AbstractAdult T‐cell leukemia/lymphoma (ATLL) has a wide variety of clinical presentations. The most common ones include leukemia, hypercalcemia, lymphadenopathy, hepatosplenomegaly, and skin lesions. We report a case of ATLL in a 73‐year‐old woman who presented initially with chest discomfort and shortness of breath. The patient had no peripheral lymphadenopathy, circulating lymphoma cells, hepatosplenomegaly, or skin lesions. CT scan showed small mediastinal lymph nodes and pericardial effusion. Diagnosis was established by cytomorphologic evaluation and flow cytometric analysis of the pericardial fluid. Cardiac involvement is a rare event in ATLL and, when present, usually is a late finding in the setting of disseminated disease. This case was unusual because the patient lacked all common clinical features of ATLL. We present this case so as to increase awareness that ATLL could initially present with pericardial effusion. The pathophysiologic mechanisms of cardiac involvement are also discussed. Am. J. Hematol. 77:381–383, 2004. © 2004 Wiley‐Liss, Inc.
Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
Authors: Luderer Ulrike , Bushley Abigail , Stover Bert D. , Bremner William J. , Faustman Elaine M. , Takaro Timothy K. , Checkoway Harvey , Brodkin Carl Andrew 
Published: November 2004

AbstractBackgroundLittle is known about the effects of organic solvents on male reproductive health. To assess fertility and reproductive endocrine function in solvent‐exposed men, we investigated time‐to‐pregnancy using a retrospective cohort design and cross‐sectionally measured reproductive hormone concentrations in painters and millwrights compared to a reference group of carpenters.MethodsDetailed occupational, exposure, medical, and time‐to‐pregnancy histories were obtained by telephone interview. Plasma luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Exposure indices, which summarized working life exposure to total solvents, chlorinated solvents, aromatic solvents, and thinners, degreasers, varnishes, and adhesives as a category were calculated from exposure histories.ResultsFSH concentrations increased significantly with increasing exposure indices for all solvents and for chlorinated solvents. There were no significant associations of solvent exposure indices with LH or testosterone levels. LH, FSH, and testosterone concentrations also did not differ by job title. Using Cox regression, time‐to‐pregnancy was non‐significantly longer in the painters and millwrights than the carpenters. There was no significant association between time‐to‐pregnancy and any of the solvent exposure indices; however, it should be noted that some of the pregnancies occurred more than 20 years previously, potentially reducing the reliability of the retrospectively collected pregnancy and exposure data.ConclusionsThe significant associations between FSH levels and solvent exposure indices suggest the potential for adverse effects of solvent exposures on reproductive function in men. Am. J. Ind. Med. 46:614–626, 2004. © 2004 Wiley‐Liss, Inc.
Finally, a sense of closure? Animal models of human ventral body wall defects
Authors: Brewer Stephanie , Williams Trevor 
Published: November 2004

AbstractMalformations concerning the ventral body wall constitute one of the leading categories of human birth defects and are present in about one out of every 2000 live births. Although the occurrence of these defects is relatively common, few detailed experimental studies exist on the development and closure of the ventral body wall in mouse and human. This field is further complicated by the array of theories on the pathogenesis of body wall defects and the likelihood that there is no single cause for these abnormalities. In this review, we summarize what is known concerning the mechanisms of normal ventral body wall closure in humans and mice. We then outline the theories that have been proposed concerning human body wall closure abnormalities and examine the growing number of mouse mutations that impact normal ventral body wall closure. Finally, we speculate how studies in animal models such as mouse andDrosophilaare beginning to provide a much‐needed mechanistic framework with which to identify and characterize the genes and tissues required for this vital aspect of human embryogenesis. BioEssays 26:1307–1321, 2004. © 2004 Wiley Periodicals, Inc.
Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition
Authors: Dixon Isabelle M. , Lopez Frédéric , Estève Jean‐Pierre , Tejera Agueda M. , Blasco María A. , Pratviel Geneviève , Meunier Bernard 
Published: November 2004

AbstractThe capacity of G‐quadruplex ligands to stabilize four‐stranded DNA makes them able to inhibit telomerase, which is involved in tumour cell proliferation. A series of cationic metalloporphyrin derivatives was prepared by making variations on a meso‐tetrakis(4‐N‐methyl‐pyridiniumyl)porphyrin skeleton (TMPyP). The DNA binding properties of nickel(II) and manganese(III) porphyrins were studied by surface plasmon resonance, and the capacity of the nickel porphyrins to inhibit telomerase was tested in a TRAP assay. The nature of the metal influences the kinetics (the process is faster for Ni than for Mn) and the mode of interaction (stacking or external binding). The chemical alterations did not lead to increased telomerase inhibition. The best selectivity for G‐quadruplex DNA was observed for Mn‐TMPyP, which has a tenfold preference for quadruplex over duplex.
Water‐Soluble Molecular Capsules: Self‐Assembly and Binding Properties
Authors: Corbellini Francesca , Knegtel Ronald M. A. , Grootenhuis Peter D. J. , Crego‐Calama Mercedes , Reinhoudt David N. 
Published: November 2004

AbstractThe self‐assembly and characterization of water‐soluble calix[4]arene‐based molecular capsules (1⋅2) is reported. The assemblies are the result of ionic interactions between negatively charged calix[4]arenes 1 a and 1 b, functionalized at the upper rim with amino acid moieties, and a positively charged tetraamidiniumcalix[4]arene 2. The formation of the molecular capsules is studied by 1H NMR spectroscopy, ESI mass spectrometry (ESI‐MS), and isothermal titration calorimetry (ITC). A molecular docking protocol was used to identify potential guest molecules for the self‐assembled capsule 1 a⋅2. Experimental guest encapsulation studies indicate that capsule 1 a⋅2 is an effective host for both charged (N‐methylquinuclidinium cation) and neutral molecules (6‐amino‐2‐methylquinoline) in water.
A Comparison of Structure and Stability Between the Group 11 Halide Tetramers M4X4 (M: Cu, Ag, or Au; X: F, Cl, Br, or I) and the Group 11 Chloride and Bromide Phosphanes (XMPH3)4
Authors: Schwerdtfeger Peter , Krawczyk Robert P. , Hammerl Anton , Brown Reuben 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Micrometric Single Crystal Germanates Obtained Using a Double‐Spherical Mirror Furnace.
Authors: Juarez‐Arellano E. A. , Rosales I. , Gamboa‐Espinosa G. V. , Lara J. A. , Bucio L. , Orozco E. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐α‐Benzyloxyacetyl Derivatives of (S)‐4‐Benzyl‐5,5‐dimethyloxazolidin‐2‐one for the Asymmetric Synthesis of Differentially Protected α,β‐Dihydroxyaldehydes.
Authors: Davies Stephen G. , Hunter Ian A. , Nicholson Rebecca L. , Roberts Paul M. , Savory Edward D. , Smith Andrew D. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Enantioselective Conjugate Addition of Malonate and β‐Ketoester to Nitroalkenes: Asymmetric C—C Bond Formation with New Bifunctional Organic Catalysts Based on Cinchona Alkaloids.
Authors: Li Hongming , Wang Yi , Tang Liang , Deng Li 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on Novel Synthetic Methodologies. Part 43. Chemoselective Deprotection of Trityl Ethers Using Silica‐Supported Sodium Hydrogen Sulfate.
Authors: Das Biswanath , Mahender Gurram , Kumar Vooturi Sunil , Chowdhury Nikhil 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Trimethylsilylcyanation of N‐[3‐(2‐Furyl)‐2‐propenylidene]trifluoromethylanilines.
Authors: Iovel I. , Golomba L. , Belyakov S. , Kemme A. , Popelis J. , Lukevics E. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intramolecular C—H Insertions Adjacent to Sulfur for the Diastereoselective Synthesis of Thienofuranones.
Authors: Skerry Paul S. , Swain Nigel A. , Harrowven David C. , Smyth Donald , Bruton Gordon , Brown Richard C. D. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of 1‐Substituted 2‐Amino‐3‐cyanopyrroles: New Synthetic Precursors for 5,6‐Unsubstituted Pyrrolo[2,3‐d]pyrimidines.
Authors: Chien Tun‐Cheng , Meade Eric A. , Hinkley Jack M. , Townsend Leroy B. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Chemoselective 2,4,5‐Triaryl‐1,3‐dioxolane Formation from Intermolecular 1,3‐Dipolar Addition of Carbonyl Ylide with Aryl Aldehydes.
Authors: Lu Chong‐Dao , Chen Zhi‐Yong , Liu Hui , Hu Wen‐Hao , Mi Ai‐Qiao 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Structure—Activity Relationships of 3,5‐Diarylisoxazoles and 3,5‐Diaryl‐1,2,4‐oxadiazoles, Novel Classes of Small Molecule Interleukin‐8 (IL‐8) Receptor Antagonists.
Authors: Weidner‐Wells Michele A. , Henninger Todd C. , Fraga‐Spano Stephanie A. , Boggs Christine M. , Matheis Michele , Ritchie David M. , Argentieri Dennis C. , Wachter Michael P. , Hlasta Dennis J. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Approaches to Synthesis of 4‐Alkyl‐6‐amino‐5‐cyano‐3‐methyl(propyl, phenyl)‐2H,4H‐pyrano[2,3‐c]pyrazoles.
Authors: Dyachenko V. D. , Rusanov E. B. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1,2,3,4‐Tetrahydroisoquinolines and 2,3,4,5‐Tetrahydro‐1H‐2‐benzazepines Combining Sequential Palladium‐Catalyzed ortho Alkylation/Vinylation with Aza‐Michael Addition Reactions.
Authors: Ferraccioli Raffaella , Carenzi Davide , Catellani Marta 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Cytostatic Properties of Some 6H‐Indolo[2,3‐b][1,8]naphthyridine Derivatives.
Authors: Mastalarz Henryk , Jasztold‐Howorko Ryszard , Rulko Felicja , Croisy Alain , Carrez Daniele 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation of New N6,9‐Disubstituted 2‐Phenyl‐adenines and Corresponding 8‐Azaadenines. A Feasibility Study for Application to Soid‐Phase Synthesis. Part 1.
Authors: Biagi Giuliana , Giorgi Irene , Livi Oreste , Pacchini Federica , Scartoni Valerio , Salerni Oreste LeRoy 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intramolecular Nucleophilic Substitution of Hydrogen in (Quinoxalinyl‐2)aminovinyl Derivatives as a New Approach to Pyrrolo‐ and Indolo[2,3‐b]quinoxalines.
Authors: Kotovskaya S. K. , Charushin V. N. , Perova N. M. , Kodess M. I. , Chupakhin O. N. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of α,α‐Difluoro‐β‐amino Phosphonic Acids Using Sulfinimines.
Authors: Roeschenthaler Gerd‐Volker , Kukhar Valery , Barten Jan , Gvozdovska Natalia , Belik Michael , Sorochinsky Alexander 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of 1,2,3,4,6,7,12,12b‐Octahydroindolo[2,3‐a]quinolizine and Harmicine Using a Chiral 1‐Allyl‐1,2,3,4‐tetrahydroxy‐β‐carboline as the Starting Material.
Authors: Itoh Takashi , Miyazaki Michiko , Nagata Kazuhiro , Nakamura Shigeru , Ohsawa Akio 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterisation of the First Cyanodiselenoimidocarbonate [C2N2Se2]2− Complexes
Authors: Burchell Colin J. , Aucott Stephen M. , Slawin Alexandra M. Z. , Woollins J. Derek 
Published: November 2004

Abstract[Pt(C2N2Se2)(PR3)2] (PR3 = PMe2Ph, PPh3) and [Pt(C2N2Se2)(PP)] (PP = dppe, dppm, dppf) were obtained by the reaction of the appropriate metal halide containing complex with potassium cyanodiselenoimidocarbonate. The dimeric cyanodiselenoimidocarbonate complexes [M{(C2N2Se2)(η5‐C5Me5)}2] (M = Rh Ir)] were synthesised from the appropriate transition metal dimer starting material. The cyanodiselenoimidocarbonate ligand is Se,Se‐bidentate in the monomeric complexes − the terminal CN group is approximately coplanar with the CSe2 group, and the nitrogen atom is trigonal therefore reducing the planar symmetry of the ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Octahedral Molybdenum Cluster Cyanide Complexes with Selenide and Halide Ligands in the Cluster Core
Authors: Mironov Yuri V. , Ikorskii Vladimir N. , Fedorov Vladimir E. , Ibers James A. 
Published: November 2004

AbstractTwo new octahedral molybdenum cluster cyanide complexes with mixed selenide/halide ligands in the cluster core, Cs5[Mo6Se3.6Cl4.4(CN)6] (1) and Cs5[Mo6Se3.4Br4.6(CN)6] (2), have been synthesized by the reaction of Mo6Cl12 or Mo6Br12 with an aqueous solution of Cs2Se3, and then with an aqueous solution of KCN. Both compounds have been characterized by single‐crystal X‐ray diffraction methods. The compounds are isostructural and crystallize in the trigonal space group P$\bar 3$
c1with two formula units per unit cell. The unit cell dimensions at 153 K are a = 9.8895(9) Å, c = 19.395(3) Å, V = 1642.7(3) Å3 (1) and a = 9.9805(9) Å, c = 19.763(2) Å, V = 1704.9(3) Å3 (2). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Antioxidant efficiency of oregano in frying and storage of fried products
Authors: Houhoula Dimitra P. , Oreopoulou Vassiliki , Tzia Constantina 
Published: November 2004

AbstractThe effect of oregano on the oxidative stability of cottonseed oil during frying of potato chips and on the storage stability of the products was studied. The ground spice or an ethanol‐derived extract was added to the oil before frying. The results showed that both additives decreased the rates of accumulation of conjugated dienes, polar compounds, polymerized triacylglycerols, dimeric triacylglycerols and the p‐anisidine value of the frying oil, while the hydrolytic compounds were not affected. The major decrease was observed in the accumulation of polymerized and dimeric triacylglycerols. The storage stability of the produced chips was estimated by the rate of increase of the peroxide value and of the conjugated dienes in the oil absorbed by them. Both rates were depressed when oregano was added to the frying oil, with the protective action of oregano extract being considerably greater than that of ground oregano. The protective action of oregano extracts obtained by successive extractions with petroleum ether (PE), diethyl ether (EE) and ethanol (EtOH) and added to the chips after frying was also examined. The results showed that the EE and EtOH extracts were very effective against oxidative deterioration.
Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer
Authors: Chang Young‐Woon , Jang Jae‐Young , Kim Nam‐Hoon , Lee Jae Won , Lee Hyo Jung , Jung Woon Won , Dong Seok‐Ho , Kim Hyo‐Jong , Kim Byung‐Ho , Lee Joung‐Il , Chang Rin 
Published: November 2004

AbstractInterleukin‐1B and IL‐1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL‐1B‐511T polymorphism and the risk of GC in Asians. We tested for an association between IL‐1 loci polymorphisms with increased gastric mucosal levels of IL‐1β and an increased risk of developing GC in a Korean population. Polymorphisms of IL‐1A‐889, IL‐1B‐31, IL‐1B‐511 and IL‐1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL‐1β cytokine was measured using an ELISA. The frequencies of IL‐1A, IL‐1B‐511, IL‐1B‐31 and IL‐1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal‐type GC showed a higher frequency of IL‐1B‐31T homozygotes (OR = 2.2; 95% CI = 1.1–4.3) compared with controls. Risk was also significantly increased in these patients for IL‐1B‐31T homozygotes compared with patients with diffuse‐type GC (OR = 3.4; 95% CI = 1.5–7.7). As in Caucasian populations, linkage disequilibrium between IL‐1B‐31 and IL‐1B‐511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL‐1B‐31T/IL‐1B‐511C) was opposite (IL‐1B‐511T/IL‐1B‐31C). Mucosal IL‐1β levels in H. pylori‐infected GC patients were higher in patients homozygous for IL‐1B‐31T compared with IL‐1B‐31C/T and IL‐1B‐31C/C. Thus, the combined effects of H. pylori infection and IL‐1B‐31T/IL‐1B‐511C polymorphisms with enhanced mucosal IL‐1β production contributed to the development of intestinal‐type GC in this Korean population. © 2004 Wiley‐Liss, Inc.
Human papillomavirus type 18 variants: Histopathology and E6/E7 polymorphisms in three countries
Authors: De Boer Marjon A. , Peters Lex A.W. , Aziz Mohammed Farid , Siregar Budiningsih , Cornain Santoso , Vrede M. Albert , Jordanova Ekaterina S. , Fleuren Gert Jan 
Published: November 2004

AbstractIn cervical cancer, human papillomavirus type 18 (HPV 18) and HPV 16 are predominantly related to adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs), respectively. Here, we studied whether the geographically distributed HPV intratypic variants are also associated with histologically different tumors. A total of 44 HPV 18‐positive and 91 HPV 16‐positive cervical carcinomas from Indonesian, Surinamese and Dutch patients were histologically classified using hematoxilin and eosin, periodic acid Schiff plus and Alcian Blue staining. Samples were sequenced and intratypic variants were classified into the known phylogenetic branches. The Asian Amerindian HPV 18 variant was observed in 56% of ADCs compared to 15% of SCCs (p < 0.006). The African HPV 18 variant was exclusively found in SCCs. By sequencing the HPV 18 E6 and E7 open reading frames, we found predicted amino acid changes only in 8 samples. Two amino acid changes were consistent throughout the African branch. In HPV 16‐positive tumors, we did not find a specific linkage between intratypic variants and histopathology. We conclude that HPV 18 intratypic variants are differentially associated with adenocarcinoma and squamous cell carcinoma of the cervix. The findings described here stress the biologic significance of intratypic HPV variants and might help explaining differences in the pathogenesis of cervical ADCs and SCCs. © 2004 Wiley‐Liss, Inc.
Proximity of first intercourse to menarche and the risk of human papillomavirus infection: A longitudinal study
Authors: Collins Stuart I. , Mazloomzadeh Saeideh , Winter Heather , Rollason Terry P. , Blomfield Penny , Young Lawrence S. , Woodman Ciaran B.J. 
Published: November 2004

AbstractCross‐sectional studies have suggested that compared with women who delay the start of their sexual career, those who first have intercourse soon after menarche are more susceptible to cervical human papillomavirus (HPV) infection and thus have a greater risk of cervical neoplasia. We describe, using longitudinal observations, how the risk of infection with HPV varies with the interval between menarche and first intercourse in 474 women aged 15–19 recruited within 12 months of first intercourse and before the acquisition of a second sexual partner. One hundred forty‐five women became HPV‐positive; the cumulative risk of HPV infection 3 years after first intercourse was 45.0% (95% CI = 37.9–51.2). In univariate analyses, the hazards ratio (HR) of HPV infection increased significantly with age at first intercourse (HR = 1.212 per year; 95% CI = 1.050–1.398), partner age (HR = 1.084 per year; 95% CI = 1.045–1.125) and when women reported a sexually experienced partner (HR = 2.794; 95% CI = 1.804–4.326); the interval between menarche and first intercourse was a significant predictor of infection, with an increase in the HR of 12.9% for every year of increase in this interval (95% CI = 2.1%–24.9%). In a multivariate analysis, compared with women who first had intercourse within 3 years of menarche, those who postponed first intercourse beyond this time had a greater risk of infection (HR = 1.581; 95% CI = 1.113–2.245) after controlling for age and sexual experience of partner. © 2004 Wiley‐Liss, Inc.