bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Hypertension associated with Congenital Heart Disease
Authors: Venkatesh Prashanth , Rosenzweig Erika B. 
Published: November 2023

:
Pulmonary hypertension in patients with congenital heart disease is associated with significant
mortality, morbidity and health services utilization. The predominant subtype of pulmonary
hypertension in these patients is pulmonary arterial hypertension (PAH). PAH associated
with congenital heart disease (PAH-CHD) comprises up to one-third of all PAH cases globally
and is most commonly associated with anatomically simple shunt lesions. A myriad of clinical
phenotypes of PAH-CHD are seen across the spectrum of shunt size, location and directionality.
A conceptual framework to categorize these patients based on pathophysiology is described. Contemporary
data regarding the management of the varied phenotypes are reviewed, and a novel algorithm
to guide decision-making with shunt closure in patients with PAH-CHD is provided. Further
data spanning the spectrum of basic, translational and clinical science are much needed to further
inform the management of this highly complex and heterogeneous population.
CT Findings of Stage IA Ovarian Cancer: Comparison with Borderline Tumor
and Stage IC Ovarian Cancer
Authors: Cui Li Wen , Zhu Xing Hua , Fan Lu Yao , Zhang Li , Shen Zhi Yong 
Published: November 2023

Background::
Ovarian cancer is a common gynecological malignant tumor in women. Most patients have reached the advanced stage when they visit the
hospital. In order to diagnose ovarian cancer at an early stage, treat it at an early stage, and improve the survival rate of patients, this study has used
the imaging computed tomography (CT) method to diagnose stage IA ovarian cancer.

Purpose::
The purpose of this work was to study CT features of stage IA ovarian cancer, and compare the borderline tumor and stage IC ovarian cancer at the
same time so as to improve the CT diagnosis of early ovarian cancer.

Methods::
We retrospectively collected clinical and CT data of patients with stage I ovarian cancer and borderline ovarian tumor admitted to Nantong Tumor
Hospital from 2013 to 2021. Altogether, 23 cases of patients (borderline ovarian tumor, 9 cases; stage IA ovarian cancer, 5 cases; stage IC ovarian
cancer, 9 cases) were involved. CT characteristics of these patients were analyzed in terms of the tumor diameter, cystic solid structure, solid
component, septation, enhancement, peritoneal thickening, ascites, and abdominal lymph nodes.

Results::
and enhanced cystic wall, septum, or solid components of the tumor on contrast-enhanced CT (5/5; 100%) no peritoneal thickening (0/5; 0%), no
ascites (0/5; 0%), and no abdominal lymph node enlargement (0/5; 0%). The tumor structure did not differ significantly between stage IA and IC
ovarian cancers (p > 0.05), while intraperitoneal ascites did (χ2 = 0.031; p < 0.05). Stage IA and borderline ovarian tumors did not differ
significantly in ovarian tumor structure (p > 0.05).

Conclusion::
CT features of stage IA ovarian cancer included large tumor size, cystic solid structure, septation, and enhanced cystic wall and solid parts in the
tumors. No pelvic or abdominal metastasis was observed.
Seed Oils as Tyrosinase Inhibitors for the Treatment of Hyperpigmentation
Authors: Kothapalli Lata , Dhakane Tanuja , Bhosale Komal , Thomas Asha 
Published: November 2023

Background:
Hyperpigmentation is a growing problem worldwide among various skin diseases and directly relates to the quality of life. The factors causing hyperpigmentation may range from
excess exposure to sunlight, pollution, underlying disease conditions, adverse effects of a medication,
modified lifestyle, and oxidative stress. Treatment includes the use of hydroquinone, retinoids, corticosteroids, and kojic acid along with anti-inflammatory drugs. However, these medications are preferred
for short-term treatment under acute conditions, while in the case of long-term treatment, botanical
extracts are a safe choice for a majority of the population for the treatment of hyperpigmentation. Formulation with plant extracts/oil enriched with polyphenols, vitamin C, and vitamin E are reported to be
safe and effective in inhibiting melanogenesis.

Objective:
Seed oils composed of polyphenols, vitamins and unsaturated fatty acids were selected to
evaluate their antioxidant property and tyrosinase enzyme inhibitory activity.

Methods:
Grape seed oil (GSO), papaya seed oil (PSO), and carrot seed oil (CSO) were evaluated for
their total phenolic and flavonoid content , in-vitro antioxidant activity was done using DPPH assay
and anti-tyrosinase activity was done usingMushroomtyrosinaseinhibition assay.

Results:
Total phenolic content for PSO was 0.936 mg/gm. Gallic acid equivalent (GAE) was highest
when compared to GSO and CSO, while CSO had a higher total flavonoid concentration, 0.945 mg/gm
as quercetin equivalent (QE). Free radical scavenging activity was comparable to standard and tyrosinase inhibitory activity for grape and carrot seed oils were 80.10 % and 76.52 % at 100µg/ml, respectively and was comparable to kojic acid used as standard.

Conclusion:
The results obtained suggest that the oils can be formulated as a topical depigmenting
product and used for skin care and skin glow
The Design and Implementation of a Wide-band Circularly Polarized
Conformal Antenna
Authors: Zheng Xiaodong , Yu Bao guo , Yang Feng , Lv Junwei 
Published: November 2023

Background:
It gives out the design and verification of single-layer dual-band antenna
unit and multi-layer dual-band broadband antenna unit of phased array antenna, and verifies that
the multi-layer dual-band broadband antenna unit can meet the design requirements of the receiving
frequency band.

Objective:
It gives out the design and implementation of a wide-band circularly polarized conformal
antenna, and presents the characteristics analysis of the antenna.

Method:
Through related simulation methods, the proposed methods are verified and they can
effectively solve the array phase compensation and beam shaping and control in the wide-band
circularly polarized conformal antenna.

Results:
Based on the basic design of the antenna, the active superposition algorithm, phase compensation
technology and particle swarm optimization antenna beam shaping technology are both studied.

Conclusion:
The proposed wide-band circularly polarized conformal antenna can be used in the
actual application.
Comprehensive Study of Low-Power SRAM Design Topologies
Authors: Srivastav Anandita , Tripathi Shailendra Kumar , Tiwari Usha , Mandal Sushanta Kumar 
Published: November 2023

:
The need for low power in portable and smart devices is the demand to be fulfilled for
sustaining the semiconductor industry. Static Random Access Memory (SRAM) is the main part
of the core design in chips. It is important to reduce the leakage power consumption during the
steady mode of the device for the long run of the battery. This article is about the study of different
modules using pre-existing low power. Application of different methods other than lowering
the supply voltage leads to an increment in the number of transistors in conventional 6T (six transistor)
SRAM cells like 7T to 14T. Power gating and the Multi-threshold complementary metal
oxide semiconductor (MTCMOS) technique is the most relevant method. Hybrid low power techniques
are in high demand because it shows better results than using individual techniques. However,
the biggest challenge is to maintain the area and delay as well. FinFET came into the scenario
to overcome the leakage power and short channel effect due to scaling in CMOS. Comparative
study analysis shows that FinFET decreases the overall power and delay even when the number of
transistors increases. A comparison was done between 6T, 8T, and 10T using FinFET and CMOS
in a paper, and concluded that FinFET shows 77.792% improved write power.
Research Update on the Therapeutic Potential of Garden Cress (Lepidium
sativum Linn.) with Threatened Status
Authors: Gupta Suchita , Gupta Reena 
Published: November 2023

:
Garden cress (Lepidium sativum) has been used in India for medicinal purposes since
the Vedic era. Garden cress, a native of Egypt and southwest Asia, is a small perennial edible
herb that has been used to treat many diseases for centuries. The seeds, leaves as well as roots
have medicinal properties. The seeds are rich in protein, fat, calcium, and iron and have high
nutritional value. They are considered to be galactagogue, anticarcinogenic, antidiabetic, antiasthmatic
and antidiarrheal. Leaves, seeds, and aerial parts extracts are found to have alkaloids,
flavonoids, glycosides, polypeptides, vitamins, minerals, proteins, fats, and carbohydrates.
Lepidium sativum is known for its pungent odor due to the several volatile oils and has been
used to treat various conditions, including respiratory disorders, muscle pain, inflammation, and
bone fractures in the past. Lepidium sativum is a fast-growing annual herb; in India, it is commonly
known as Chandrasoor. Whole fruits or seeds are used, fresh or dried, as a seasoning
with a peppery flavor. Boiled seeds are consumed in drinks by Arabs, either ground in honey or
as an infusion in hot milk. The seed oil can be used for illumination and soap making. Additionally,
limited awareness and conservation efforts have further contributed to its threatened
status. Recognizing the importance of preserving this valuable plant species is crucial for maintaining
biodiversity and ensuring its availability for future generations. Furthermore, this review
explores the potential benefits of Lepidium sativum in different domains. Its nutritional value
and health benefits make it a promising candidate for addressing malnutrition and improving
overall well-being. The presence of bioactive compounds suggests its potential use in functional
foods, pharmaceuticals, and natural medicines for various ailments. Moreover, Lepidium sativum
exhibits antimicrobial and insecticidal properties, offering potential applications in agriculture
and pest control. The current review discussed the nutritional, potential benefits and
pharmacological effects of Lepidium sativum.
Pandemic Preparedness for COVID-19: Research, Healthcare, and
Pharmaceutical Perspectives
Authors: Mani Israel , Nandakumar Manikandan Bilal , Balakrishnan Amara Balan , Rahamathulla Mohamudha Parveen , Pandi Mohan 
Published: November 2023

Abstract:
The COVID-19 pandemic has highlighted the critical importance of pandemic preparedness
worldwide, following the devastating 1918 pandemic. The rapid spread of COVID-19, originating
in China, led to its classification as a global pandemic by the World Health Organization.
COVID-19 is a member of the Coronaviridae family, a large family of viruses that have undergone
extensive mutation and evolution over time. Among the coronaviruses, SARS-CoV-2, a Betacoronavirus,
has emerged as a highly virulent pathogen capable of causing severe illness and fatalities
in both humans and animals. Since 1966, various types of coronaviruses have surfaced, each
exhibiting distinct mutations and structural characteristics. These genetic changes have contributed to
the enhanced potency of the virus, intensifying the global pandemic crisis we face today. In response,
the pharmaceutical approach to combat COVID-19 encompasses a multifaceted strategy. This includes
the development of novel antiviral drugs specifically targeting the virus, as well as the repurposing
of existing medications to evaluate their effectiveness against the virus. Additionally, there is
a growing interest in exploring the potential of herbal and traditional medicine in the treatment of
COVID-19. Continued research and collaboration among scientists, healthcare professionals, and
pharmaceutical companies are crucial in the quest to find effective treatments for COVID-19 and to
mitigate the impact of future coronavirus outbreaks. It is imperative to recognize the power and
adaptability of microorganisms, emphasizing the need for vigilance and caution in preventing and
managing infectious diseases. By investing in robust pandemic preparedness, measures and fostering
global cooperation, we can enhance our ability to respond effectively to emerging viral threats and
safeguard public health.
Co-Design of a Virtual Reality Multiplayer Adventure Game for Adolescents With Autism Spectrum Disorder: Mixed Methods Study
Authors: Gabrielli Silvia , Cristofolini Melanie , Dianti Marco , Alvari Gianpaolo , Vallefuoco Ersilia , Bentenuto Arianna , Venuti Paola , Mayora Ibarra Oscar , Salvadori Elio 
Published: November 2023

Background
Virtual reality (VR) adventure games can offer ideal technological solutions for training social skills in adolescents with autism spectrum disorder (ASD), leveraging their support for multisensory and multiplayer interactions over distance, which may lower barriers to training access and increase user motivation. However, the design of VR-based game environments for social skills training is still understudied and deserves the deployment of an inclusive design approach to ensure its acceptability by target users.

Objective
We aimed to present the inclusive design process that we had followed to develop the Zentastic VR adventure game to foster social skills training in adolescents with ASD and to investigate its feasibility as a training environment for adolescents.

Methods
The VR game supports multiplayer training sessions involving small groups of adolescents and their therapists, who act as facilitators. Adolescents with ASD and their therapists were involved in the design and in an explorative acceptability study of an initial prototype of the gaming environment, as well as in a later feasibility multisession evaluation of the VR game final release.

Results
The feasibility study demonstrated good acceptability of the VR game by adolescents and an enhancement of their social skills from baseline to posttraining.

Conclusions
The findings provide preliminary evidence of the benefits that VR-based games can bring to the training of adolescents with ASD and, potentially, other neurodevelopmental disorders.
Оцінка функціональних результатів, стану сітківки й зорового нерва після вітреоретинальних втручань із застосуванням газової тампонади у хворих на проліферативну діабетичну ретинопатію
Authors: Putienko O.O. , Panchenko Y.O. , Mogilevskyy S.Y. 
Published: November 2023

Актуальність. Метою дослідження було провести оцінку функціональних результатів стану сітківки й зорового нерва після вітреоретинальних втручань із застосуванням тільки газової тампонади у хворих на проліферативну діабетичну ретинопатію (ПДР) з різними стадіями проліферативного процесу. Матеріали та методи. Під спостереженням перебувало 48 хворих (48 очей) на ПДР з повною прозорістю вітреального вмісту через 2 місяці після операції. Показанням до вітректомії на 26 очах (54,2 %) був гемофтальм, екстрамакулярна епіретинальна мембрана (ЕРМ) без тракційного відшарування макули — I група. II група — 18 очей (37,5 %) з ЕРМ і тракційним відшаруванням макули і 4 ока (8,3 %) — з тракційно-регматогенним відшаруванням сітківки. Вітректомію виконували калібром 25 G за стандартною схемою. Результати. У пацієнтів, у яких до операції макула була прилеглою, гострота зору покращується в 92,3 % випадків, у випадках з тракційним відшаруванням макули — в 72,7 %. Товщина сітківки після вітректомії у хворих, у яких до операції макула була прилеглою, становить у середньому 206,0 ± 16,8 (без ознак макулярного набряку), стоншення шару нервових волокон в 1 секторі має місце в 16,6 % випадків. У пацієнтів із тракційним відшаруванням макули товщина сітківки в макулярній зоні після вітректомії становить у середньому 291,0 ± 108,7 (у 15 % випадків має місце макулярний набряк), стоншення шару нервових волокон спостерігається в 75 % випадків, переважно в 1 секторі (60 % випадків). Гострота зору значущо нижче при стоншенні шару нервових волокон одночасно верхнього і нижнього секторів (коефіцієнт кореляції R = 0,682; р = 0,031) і при стоншенні шару волокон у трьох секторах і більше (R = 0,713; р = 0,028). Висновки. Виконання вітректомії в ранньому терміні (з макулою, яка до операції була прилеглою) є головним чинником збереження високої функціональної активності сітківки й зорового нерва зі збереженням високих зорових функцій.
Comparative Safety of Antidepressants in Adults with CKD
Authors: Zhu Nanbo , Xu Hong , Lagerberg Tyra , Johnell Kristina , Carrero Juan Jesús , Chang Zheng 
Published: November 2023

Background
Depression is prevalent in patients with CKD and is related to poor prognosis. Despite the widespread use of antidepressants in the CKD population, their safety remains unclear.

Methods
We identified adults with CKD stages G3–5 (eGFR <60 ml/min per 1.73 m2 not treated with dialysis) and incident depression diagnosis during 2007–2019 from the Stockholm Creatinine Measurements project. Using the target trial emulation framework, we compared the following treatment strategies: (1) initiating versus not initiating antidepressants, (2) initiating mirtazapine versus selective serotonin reuptake inhibitors (SSRIs), and (3) initiating SSRIs with a lower dose versus a standard dose.

Results
Of 7798 eligible individuals, 5743 (74%) initiated antidepressant treatment. Compared with noninitiation, initiation of antidepressants was associated with higher hazards of short-term outcomes, including hip fracture (hazard ratio [HR], 1.23; 95% confidence interval [CI], 0.88 to 1.74) and upper gastrointestinal bleeding (HR, 1.38; 95% CI, 0.82 to 2.31), although not statistically significant. Initiation of antidepressants was not associated with long-term outcomes, including all-cause mortality, major adverse cardiovascular event, CKD progression, and suicidal behavior. Compared with SSRIs, initiation of mirtazapine was associated with a lower hazard of upper gastrointestinal bleeding (HR, 0.52; 95% CI, 0.29 to 0.96), but a higher hazard of mortality (HR, 1.11; 95% CI, 1.00 to 1.22). Compared with the standard dose, initiation of SSRIs with a lower dose was associated with nonstatistically significantly lower hazards of upper gastrointestinal bleeding (HR, 0.68; 95% CI, 0.35 to 1.34) and CKD progression (HR, 0.80; 95% CI, 0.63 to 1.02), but a higher hazard of cardiac arrest (HR, 2.34; 95% CI, 1.02 to 5.40).

Conclusions
Antidepressant treatment was associated with short-term adverse outcomes but not long-term outcomes in people with CKD and depression.
Strategies to Guide Preemptive Waitlisting and Equity in Waittime Accrual by Race/Ethnicity
Authors: Ku Elaine , Copeland Timothy , Chen Ling-Xin , Weir Matthew R. , McCulloch Charles E. , Johansen Kirsten L. , Goussous Naeem , Savant Jonathan D. , Lopez Isabelle , Amaral Sandra 
Published: November 2023

Background
Use of eGFR to determine preemptive waitlisting eligibility may contribute to racial/ethnic disparities in access to waitlisting, which can only occur when the eGFR falls to ≤20 ml/min per 1.73 m2. Use of an alternative risk-based strategy for waitlisting may reduce these inequities (e.g., a kidney failure risk equation [KFRE] estimated 2-year risk of kidney failure) rather than the standard eGFR threshold for determining waitlist eligibility. Our objective was to model the amount of preemptive waittime that could be accrued by race and ethnicity, applying two different strategies to determine waitlist eligibility.

Methods
Using electronic health record data, linear mixed models were used to compare racial/ethnic differences in preemptive waittime that could be accrued using two strategies: estimating the time between an eGFR ≤20 and 5 ml/min per 1.73 m2 versus time between a 25% 2-year predicted risk of kidney failure (using the KFRE, which incorporates age, sex, albuminuria, and eGFR to provide kidney failure risk estimation) and eGFR of 5 ml/min per 1.73 m2.

Results
Among 1290 adults with CKD stages 4–5, using the Chronic Kidney Disease Epidemiology Collaboration equation yielded shorter preemptive waittime between an eGFR of 20 and 5 ml/min per 1.73 m2 in Black (−6.8 months; 95% confidence interval [CI], −11.7 to −1.9), Hispanic (−10.2 months; −15.3 to −5.1), and Asian/Pacific Islander (−10.3 months; 95% CI, −15.3 to −5.4) patients compared with non-Hispanic White patients. Use of a KFRE threshold to determine waittime yielded smaller differences by race and ethnicity than observed when using a single eGFR threshold, with shorter time still noted for Black (−2.5 months; 95% CI, −7.8 to 2.7), Hispanic (−4.8 months; 95% CI, −10.3 to 0.6), and Asian/Pacific Islander (−5.4 months; −10.7 to −0.1) individuals compared with non-Hispanic White individuals, but findings only met statistical significance criteria in Asian/Pacific Islander individuals. When we compared potential waittime availability using a KFRE versus eGFR threshold, use of the KFRE yielded more equity in waittime for Black (P = 0.02), Hispanic (P = 0.002), and Asian/Pacific Islander (P = 0.002) patients.

Conclusions
Use of a risk-based strategy was associated with greater racial equity in waittime accrual compared with use of a standard single eGFR threshold to determine eligibility for preemptive waitlisting.
Dampak Peran Ganda Petani Perempuan dalam Kehidupan Rumah Tangga di Masa Kini
Authors: Hamdani Thaha  , Yuniar Vera 
Published: November 2023

The dual role of women is the active involvement of women in the process of achieving goals based on independent personal abilities in deciding a goal. Women as wives for their husbands and as mothers of children is a status that has consequences for their role in family life, but sometimes that role does not function properly because it is accompanied by other roles as breadwinners, sometimes even that role becomes dominant to women's attention because it is related to family survival. The purpose of this study was to impact the dual role women to work as farmers in Gamaru Hamlet, Ulusalu Village, Latimojong District, Luwu Regency, South Sulawesi. This research is a type of qualitative research with a case study approach. Researchers obtained data through observation, interviews and documentation. The results of this study are four impacts experienced by women in carrying out their dual roles as farmers in Gamaru Hamlet, Ulusalu Village, Latimojong District, Luwu Regency, namely first Social Status, second Economic Impact, third Impact on family life, fourth Social Impact. The implications of the research are expected to be able to change people's views that domestic roles are not only women's affairs (wife) but also husband's affairs.
Increasing the Learning Motivation of Three-Dimensional Material for 5th Grade in Public Elementary School 2 Palaan Through SALAM Media "Snake & Ladder Math"
Authors: Sa`diyah Halimatus , Syari’ah Atiris , Hikmatus Shoumi Indah Nur , Rohmah Ainur , Buchori Imam 
Published: November 2023

Sometimes, it is easy for students to feel bored during the learning process. The saturation experienced by students can be caused by the large amount of material that must be mastered, one of which is Three-Dimensional material. In elementary school, mathematics is generally a less desirable subject. Therefore, elementary school teachers need to package it using learning media that are in accordance with students' character. This community services seeks to trace the effective learning media applied in 5th grade of SDN 2 Palaan through a descriptive approach and inductively analysis. The result is that the SALAM learning media "Snake & Ladder Math" is an appropriate learning media for Three-Dimensional material.