bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of multimodal noninvasive follow‐up for pediatric ulcerative colitis: A single‐center prospective study
Authors: Spyropoulou Vasiliki , Russo Giusy , Rossi Eleonora Dei , Ruggiero Cosimo , Volpe Danila , D'Arcangelo Giulia , Papoff Paola , Civitelli Fortunata , Aloi Marina , Oliva Salvatore 
Published: December 2023

AbstractObjectivesUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) often requiring endoscopic evaluations, which can be uncomfortable and costly, especially for children. This study aimed to evaluate the diagnostic accuracy of a noninvasive approach combining fecal calprotectin (FCP), colonic ultrasonography (US), and colon capsule endoscopy (CCE) compared with standard ileocolonoscopy in pediatric UC.MethodsUC children were enrolled and underwent FCP and US on Day 0, followed by CCE on Day 1 and ileocolonoscopy on Day 2. All procedures were performed by operators who were blinded to the patient's clinical history and all test results. The accuracy for disease activity and extension of each technique and their combination was assessed and compared. Tolerability and safety were also evaluated.ResultsThirty‐two patients were enrolled (15 males, mean age 13.2 ± 3.2 years). CCE showed a sensitivity of 95% and specificity of 100% in detecting colonic inflammation, with positive predictive value (PPV) and negative predictive value (NPV) of 100% and 92%, respectively. US demonstrated a sensitivity of 85% and specificity of 92%, with PPV and NPV of 94% and 79%. The combination of FCP, US, and CCE achieved 95% sensitivity and 100% specificity, with PPV of 100% and NPV of 92%. The noninvasive approach was better tolerated than colonoscopy (p < 0.05), and no serious adverse events were reported.ConclusionThe noninvasive approach combining fecal calprotectin (FCP), ultrasonography, and colon capsule endoscopy demonstrated high diagnostic accuracy and better tolerability compared with standard ileocolonoscopy in pediatric ulcerative colitis follow‐up. Further multicenter studies are needed to confirm these findings and evaluate the reproducibility of this noninvasive approach.
Assessment of families' experience with care integration within an aerodigestive program
Authors: Pottorff Alexandra , Liu Enju , Du Maritha , Catacora Andrea , Rosen Rachel , McSweeney Maireade 
Published: December 2023

AbstractObjectivesThe objective of this study was to assess if enrollment in a pediatric multidisciplinary aerodigestive program significantly impacted families' experiences with care integration.MethodsA previously validated 48‐question Pediatric Integrated Care Survey (PICS) was administered in a cross‐sectional manner to both new (new‐ADC) and established (est‐ADC) patients presenting for an outpatient Aerodigestive Center visit at Boston Children's Hospital. Survey results were grouped into the following five care coordination domains: (1) access to care, (2) care goal creation/planning, (3) family impact, (4) communication with health care providers, and (5) team functioning. Families were asked to rate their care integration experiences in the prior 12 months using yes/no and Likert‐based questions. Comparisons were analyzed using logistic regression. Factor analysis was also performed.ResultsNinety patient families were surveyed: 54 (60%) est‐ADC patients and 36 (40%) new‐ADC patients. Est‐ADC patients reported higher levels of experience with team functioning, provider awareness of prior testing, provider communication, and access to alternative methods of communication. Self‐identified non‐White patients reported lower satisfaction in team functioning and provider understanding of their child's long‐term care plan. No significant differences in care integration experiences before and after the onset of the coronavirus pandemic were seen.ConclusionsPatients enrolled in aerodigestive centers experienced improved care integration, most significantly in provider communication and team functioning. Despite these improvements, self‐identified non‐White families reported a lower care integration experience.
High oxidative stability of a complex fish liver oil nano‐capsules in response to long‐term storage, and to hyperthermal and sunlight exposure
Authors: Tsai Ming‐Fong , Nargotra Parushi , Liao Kuan‐Ting , Wang Hui‐Min David , Tsai Yung‐Hsiang , Liu Yung‐Chuan , Kuo Chia‐Hung 
Published: December 2023

AbstractBACKGROUNDIn this study, a biocompatible nano‐carrying platform using chitosan (ChI) and chondroitin sulfate (ChS) was developed for the encapsulation of cobia liver oil (CBLO) to prevent its oxidation and improve its absorption. An ionic gelation method was applied to encapsulate CBLO with different weight ratios (from 1.0 to 1.5) to obtain ChS‐ChI nano‐capsules (ChS‐ChI@CBLO NCs).RESULTSMorphological observations of the nano‐capsules revealed a spherical shape and diameter around 267–381 nm. The maximum loading capacity (LC) and encapsulation efficiency (EE) for ChS‐ChI@CBLO NCs estimated by thermogravimetric analysis (TGA) and derivative thermogravimetric (DTG) analysis were 25.7% and 56.2%, respectively. The structural stability of ChS‐ChI@CBLO NCs was confirmed through differential scanning calorimetry (DSC) and X‐ray diffraction (XRD) analysis; moreover DSC also further confirmed the oxidative stability of ChS‐ChI@CBLO NCs. Fourier‐transform infrared (FTIR) spectra confirmed the excellent stability of ChS‐ChI@CBLO NCs against high temperature and sunlight exposure. Biocompatibility analysis also verified the non‐toxicity of ChS‐ChI@CBLO NCs, further indicating safety and potential application in complex‐nutritional supplements.CONCLUSIONNano‐degree of ChS‐ChI@CBLO NCs has a loading capacity and encapsulation efficiency of around 16.5 ~ 25.7% and 33.4 ~ 56.2%, respectively, for encapsulation of CBLO. Characterization results also indicate that ChS‐ChI@CBLO NCs display high oxidative stability against long‐term, hyperthermal, and sunlight exposure. Bioassay results confirm that the ChS‐ChI@CBLO NCs are safe and non‐toxic. This study demonstrates that nano‐capsules are also beneficial in preventing sensitive compounds from metamorphosis, and are non‐toxic. These materials are suitable for use in the food and pharmaceutical industries. © 2023 Society of Chemical Industry.
Gain‐of‐Function KIDINS220 Variants Disrupt Neuronal Development and Cause Cerebral Palsy
Authors: Zhang Jin , Zhang Yandong , Shang Qing , Cheng Ye , Su Yu , Zhang Junjie , Wang Ting , Ding Jian , Li Yunqian , Xie Yunli , Xing Qinghe 
Published: December 2023

AbstractBackgroundKinase D‐interacting substrate of 220 kDa (KIDINS220) is a multifunctional scaffolding protein essential for neuronal development. It has been implicated in neurological diseases with either autosomal dominant (AD) or autosomal recessive (AR) inheritance patterns. The molecular mechanisms underlying the AR/AD dual nature of KIDINS220 remain elusive, posing challenges to genetic interpretation and clinical interventions. Moreover, increased KIDINS220 exhibited neurotoxicity, but its role in neurodevelopment remains unclear.ObjectiveThe aim was to investigate the genotype–phenotype correlations of KIDINS220 and elucidate its pathophysiological role in neuronal development.MethodsWhole‐exome sequencing was performed in a four‐generation family with cerebral palsy. CRISPR/Cas9 was used to generate KIDINS220 mutant cell lines. In utero electroporation was employed to investigate the effect of KIDINS220 variants on neurogenesis in vivo.ResultsWe identified in KIDINS220 a pathogenic nonsense variant (c.4177C > T, p.Q1393*) that associated with AD cerebral palsy. We demonstrated that the nonsense variants located in the terminal exon of KIDINS220 are gain‐of‐function (GoF) variants, which enable the mRNA to escape nonsense‐mediated decay and produce a truncated yet functional KIDINS220 protein. The truncated protein exhibited significant resistance to calpain and consequently accumulated within cells, resulting in the hyperactivation of Rac1 and defects in neuronal development.ConclusionsOur findings demonstrate that the location of variants within KIDINS220 plays a crucial role in determining inheritance patterns and corresponding clinical outcomes. The proposed interaction between Rac1 and KIDINS220 provides new insights into the pathogenesis of cerebral palsy, implying potential therapeutic perspectives. © 2023 International Parkinson and Movement Disorder Society.
Bckdk‐Mediated Branch Chain Amino Acid Metabolism Reprogramming Contributes to Muscle Atrophy during Cancer Cachexia
Authors: Chen Li , Zhang Hong , Chi Mengyi , Wang Yaxian , Zhu Xinting , Han Leng , Xin Bo , Gan Run , Tu Yixin , Sun Xipeng , Lu Jin , Li Jie , Huang Jinlu , Zhang Jianping , Han Yonglong , Guo Cheng , Yang Quanjun 
Published: December 2023

ScopeBranched chain amino acids (BCAAs) are essential amino acids and important nutrient signals for energy and protein supplementation. The study uses muscle‐specific branched‐chain α‐keto acid dehydrogenase kinase (Bckdk) conditional knockout (cKO) mice to reveal the contribution of BCAA metabolic dysfunction to muscle wasting.Method and resultsMuscle‐specific Bckdk‐cKO mice are generated through crossbreeding of Bckdkf/f mice with Myf5Cre mice. Lewis lung cancer (LLC) tumor transplantation is used to establish the cancer cachexia model. The occurrence of cancer cachexia is accelerated in the muscle‐specific Bckdk‐cKO mice after bearing LLC tumor. Wasting skeletal muscle is characterized by increased protein ubiquitination degradation and impaired protein synthesis. The wasting muscle gastrocnemius is mechanized as a distinct BCAA metabolic dysfunction. Based on the atrophy phenotype resulting from BCAA metabolism dysfunction, the optimized BCAA supplementation improves the survival of cancer cachexia in muscle‐specific Bckdk‐cKO mice bearing LLC tumors, and improves the occurrence of cancer cachexia. The mechanism of BCAA supplementation on muscle mass preservation is based on the promotion of protein synthesis and the inhibition of protein ubiquitination degradation.ConclusionsDysfunctional BCAA metabolism contributes to the inhibition of protein synthesis and increases protein degradation in the cancer cachexia model of muscle‐specific Bckdk‐cKO mice bearing LLC tumors. The reprogramming of BCAA catabolism exerts therapeutic effects by stimulating protein synthesis and inhibiting protein degradation in skeletal muscle.
Influence of different cooling treatments on the mechanical properties of granite under Brazilian splitting test by grain‐based model 3D
Authors: Tian Wen‐Ling , Yang Sheng‐Qi , Yin Peng‐Fei , Zhu Zhen‐Nan , Huang Yan‐Hua 
Published: December 2023

AbstractDuring the operation of an enhanced geothermal system (EGS), the reservoir rock undergoes different cooling treatments based on the distance to the surface rock. The tensile capacity of reservoir rocks is a key parameter in estimating the parameters of the hydraulic fracturing process. Therefore, the gain‐based model 3D (GBM3D) was constructed to explore the micro behavior of granite under the heating/cooling process and the Brazilian splitting test. The numerical results demonstrate the ability of GBM3D to reproduce the grain interlocking and rotational resistance behavior, making it applicable to simulate the mechanical behavior of granite under uniaxial compression and the Brazilian splitting test. Temperature and cooling rates have significant effects on the stress‐strain curves. With the increase in temperature, the curves after peak strength translate from brittle to ductile, and the turning point of water‐cooled granite is lower than that of air‐cooled granite. When more flaws are present in the specimen, micro‐cracks tend to occur along the loading axial near the center of the specimen. This result can be used to explain the defect in numerical simulation, where cracks are easy to develop near the loading position under the Brazilian splitting test. This work can provide recommendations for hydraulic fracturing.
Tracing the effect of the paycheck protection program on nonprofit capacity to sustain payroll and services during COVID‐19
Authors: Ceka Erica , Warner Lora 
Published: December 2023

AbstractThis study explores the effect of government fiscal stimulus on nonprofit performance during the COVID‐19 pandemic. More specifically, it investigates whether access to the Paycheck Protection Program (PPP) increased the ability of nonprofit organizations operating in the crisis context conditions to continue supplying funds for payroll and maintain effective delivery of services and programs after the initial revenue shock. The study findings are derived from the analysis of survey data collected from 160 Wisconsin nonprofit organizations in July and August 2020 linked to publicly available Internal Revenue Service tax filings. Regression analysis reveals a strong positive connection between the PPP loans and the nonprofit capacity to continue funding payroll and providing services within the next months of the pandemic. The empirical results suggest that the government stimulus policies offering direct economic assistance can indeed contribute to the continuity of nonprofit services and payroll in times of fiscal uncertainty, albeit the policy may not yield equally significant results across all types of organizations. This study increases the understanding of nonprofit performance during an extended revenue crisis, offering answers to policymakers, researchers, and practitioners interested in learning more about the efficacy of federal stimulus funding in enabling private organizations to mitigate the financial consequences of the COVID‐19 crisis.
Longitudinal assessment of Leydig cell function in male survivors of childhood cancer
Authors: Thrope Alexandra , Gerber Linda M , Thomas Charlene , Antal Zoltan 
Published: December 2023

AbstractBackgroundAs the number and longevity of childhood cancer survivors increases, assessing treatment‐associated late effects remains crucial. We longitudinally examined the incidence of and associated risk factors for Leydig cell dysfunction (LCD) and Leydig cell failure (LCF) in men treated for pediatric cancers at our institution.Procedure:We performed a retrospective longitudinal cohort study of adult male survivors treated for various childhood cancers who are at risk for LCD. The outcomes of interest were serum testosterone and luteinizing hormone (LH) levels during childhood and adulthood. Risk factors assessed included treatment with stem cell transplant, total body irradiation (TBI), and exposure to alkylating agents.Results:Out of 118 eligible subjects, 7.6% had LCF and 14.4% had LCD. Median age at last testosterone level was 20 years. Subjects with sufficient testosterone levels in adulthood (N = 105) remained sufficient for a mean of 11.1 years following completion of cancer treatment. We found significant associations between LCF and treatment with TBI (p < .003) and between LCF in adulthood and testosterone insufficiency in childhood (p < .001). No statistically significant association was found between LCF and cyclophosphamide equivalent dose greater than 20 g/m2 (p = .2). LCF/LCD occurred in a small number of nonirradiated patients treated with the highest doses of alkylators.Conclusions:Incidence of LCF and LCD are low in male survivors of childhood cancer. Longitudinally, there is an association between childhood testosterone insufficiency and LCF in adulthood. Alkylating agents and stem cell transplant without TBI were not associated with LCF in our study.
Methotrexate level discrepancy post‐glucarpidase: A pediatric case series and review of literature
Authors: Kibby Danielle , Trinkman Heidi 
Published: December 2023

AbstractMethotrexate is a common component of pediatric oncology treatment and delayed clearance increases risk of significant toxicities. Glucarpidase is indicated for patients with toxic plasma methotrexate concentrations with renal toxicity. Laboratory interference with immunoassay measurement post‐glucarpidase administration is well established, with current product labeling indicating this persists for 48 h. However, recent experience in pediatric patients supports this discrepancy persists beyond 48 h. Three cases experienced delayed methotrexate clearance and received glucarpidase with subsequent measurement of methotrexate levels by liquid chromatography tandem mass spectrometry (LC–MS/MS) and/or immunoassay. Within this case series, discrepancies between LC–MS/MS and immunoassay levels persisted significantly longer than 48 h.
Shingle cell IV characterization based on spatially resolved host cell measurements
Authors: Kunze Philipp , Demant Matthias , Krieg Alexander , Tummalieh Ammar , Wöhrle Nico , Rein Stefan 
Published: December 2023

AbstractEach solar cell is characterized at the end‐of‐line using current‐voltage (
) measurements, except shingle cells, due to multiplied measurement efforts. Therefore, the respective host cell quality is adopted for all resulting shingles, which is sufficient for samples with laterally homogeneous quality. Yet, for heterogeneous defect distributions, this procedure leads to (i) loss of high‐quality shingles due to defects on neighboring host cell parts, (ii) increased mismatch losses due to inaccurate binning, and (iii) lack of shingle‐precise characterization. In spatially resolved host measurements, such as electroluminescence images, all shingles are visible along with their properties. Within a comprehensive experiment, 840 hosts and their resulting shingles are measured. Thereafter, a deep learning model has been designed and optimized which processes host images and determines
parameters like efficiency or fill factor,
curves, and binning classes for each shingle cell. The efficiency can be determined with an error of
enabling a
improvement in correct assignment of shingles to bin classes compared with industry standard. This results in lower mismatch losses and higher output power on module level as demonstrated within simulations. Also,
curves of defective and defect‐free shingle cells can be derived with good agreement to actual shingle measurements.
Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation
Authors: Uday Adwaith B. , Mishra Rishi Kumar , Hussain Tanweer 
Published: December 2023

AbstractBacterial ribosomes require three initiation factors IF1, IF2, and IF3 during the initial steps of translation. These IFs ensure correct base pairing of the initiator tRNA anticodon with the start codon in the mRNA located at the P‐site of the 30S ribosomal subunit. IF3 is one of the first IFs to bind to the 30S and plays a crucial role in the selection of the correct start codon and codon: anticodon base pairing. IF3 also prevents the premature association of the 50S subunit of ribosomes and aids in ribosome recycling. IF3 is reported to change binding sites and conformation to ensure translation initiation fidelity. A recent study suggested an initial binding of IF3 CTD away from the P‐site and that IF1 and IF2 promote the movement of CTD to the P‐site and concomitant movement of NTD. Hence, to visualize the position of IF3 in the absence of any other IFs, we determined cryo‐EM structure of the 30S‐IF3 complex. The map shows that IF3 is present in an extended conformation with CTD present at the P‐site and NTD near the platform even in the absence of IF1 and IF2. Hence, IF3 CTD binds at the P‐site and moves away during the accommodation of the initiator tRNA at the P‐site in the later steps of translation initiation. Overall, we report the structure of 30S‐IF3 which demystifies the starting binding site and conformation of IF3 on the 30S ribosomal subunit.
Human organ chips for regenerative pharmacology
Authors: Goyal Girija , Belgur Chaitra , Ingber Donald E. 
Published: December 2023

AbstractHuman organs‐on‐chips (organ chips) are small microfluidic devices that allow human cells to perform complex organ‐level functions in vitro by recreating multi‐cellular and multi‐tissue structures and applying in vivo‐like biomechanical cues. Human Organ Chips are being used for drug discovery and toxicology testing as an alternative to animal models which are ethically challenging and often do not predict clinical efficacy or toxicity. In this mini‐review, we summarize our presentation that reviewed the state of the art relating to these microfluidic culture devices designed to mimic specific human organ structures and functions, and the application of Organ Chips to regenerative pharmacology.
Planar Hall Effect and Quasi ‐ 2D Anisotropic Superconductivity in Topological Candidate 1T‐NbSeTe
Authors: Patra Chandan , Agarwal Tarushi , Srivastava Shashank , Chowdhury Rajeswari Roy , Saravanan M. P. , Singh Ravi Prakash 
Published: December 2023

AbstractSuperconducting topological materials have generated considerable interest in condensed matter research due to their unusual gap structures and topological properties. In this study, the normal and superconducting characteristics of a potential topological semimetal, 1T‐NbSeTe are investigated through comprehensive transport and magnetization measurements on bulk single crystals. The results suggest the topological semimetallic nature of NbSeTe, as evidenced by the observation of the planar Hall effect. Moreover, it displays quasi‐2D anisotropic superconductivity, which breaks the Pauli limit. The coexistence of the topological semimetallic nature and superconductivity of NbSeTe makes it a potential contender for topological superconductivity.
Adaptive backstepping asymptotic consensus tracking control of multiple uncertain manipulators with disturbances
Authors: Xu Zhiguo , Zhao Lin 
Published: December 2023

AbstractThis article studies the asymptotic consensus of multiple robots with uncertain parameters and external disturbances. A novel asymptotic tracking command filtered adaptive consensus control approach is proposed. The command filters avoid the differentials of virtual control functions in backstepping, meanwhile, the compensation mechanism is used to compensate filtering errors. Compared with current command filtered control algorithms for the consensus control of multiple robots, the consensus tracking errors can asymptotically converge to origin under the given approach, moreover, the design process is simplified by designing only one adaptive parameter for each manipulator. A simulation example verifies the given approach.
Project management for sustainable development: Critical determinants of technological competency for project managers with smart technologies
Authors: Wei Feiyang , Hwang Bon‐Gang , Zhu Hanjing , Ngo Jasmine 
Published: December 2023

AbstractTo achieve sustainable development in the construction industry through effective management of projects implementing smart technologies, the technological competency of project managers (PMs) has become increasingly important. This study aims to: (i) investigate the significant attributes of PMs' technological competency when implementing smart technologies for effective project management; (ii) develop a Technological Competency Framework (TCF) for PMs; and (iii) assess critical determinants in the TCF. To achieve these objectives, the attributes of PMs' technological competency and their relative importance were investigated and assessed through a comprehensive literature review, expert interviews, a structured questionnaire survey and statistical analyses. The results showed that the identified attributes in TCF were statistically significant, with project management knowledge, personal characteristics, and skills in managing projects having the highest priority. This study enriches the knowledge of technological competency for PMs in project management and provides guidance for the industry to implement smart technologies for sustainable development.