bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monte Carlo Quantitative Risk Assessment for the Optimization of Groundwater Monitoring Programmes
Authors: Lourens Paul Joël Havemann , Vermeulen Petrus Daniel 
Published: February 2024

Abstract
Apart from the initial capital cost for the installation of the monitoring network, the cost for analysing the water quality parameters can outweigh the cost for sampling (personnel, logistics, and instrumentation), data processing, storage, and reporting. These costs can be reduced if it is possible to identify the water quality parameters that have a high risk of impacting the groundwater regime and modify the water quality parameters to be monitored, and the frequency of monitoring according to a risk of probable impact. A quantitative risk assessment, based on the Monte Carlo analysis of random sampling, was developed. The results of the Monte Carlo water quality risk assessment were used to design a new groundwater monitoring programme for an industrial waste facility. The use of the risk assessment is not limited to industrial waste facility sites. It can also be applied to other industries that have the potential to impact or have impacted the groundwater regime if historical time-series monitoring data is available.
Association between glycemia and multi-vessel lesion in participants undergoing percutaneous coronary intervention: A cross-sectional study
Authors: Dong Hezeng , Liu Zhaozheng , Chen Hao , Shi Rui , Jin Qu , Shao Xiao , Tian Tenghui , Yin Jinzhu , Chang Liping , Deng Yue 
Published: February 2024

Abstract
Background
This study aims to elucidate the association between glycemia and the occurrence of multi-vessel lesions in participants undergoing Percutaneous Coronary Intervention (PCI).
Methods
A cohort of 2,533 patients with coronary heart disease, treated with drug-eluting stents, was analysed. Of these, 1,973 patients, identified by the endpoint of multi-vessel lesions, were examined using univariate and multivariate logistic regression analyses to determine the relationship between glycemia levels and multi-vessel lesion occurrence.
Results
The analysis included 1,973 participants, among whom 474 patients were identified with coronary multi-vessel lesions. Univariate logistic regression analysis demonstrated a positive correlation between glycemia and the occurrence of coronary multi-vessel lesions (OR 1.04; 95% CI 1.01–1.08; p = 0.02)..The adjusted model indicated that for each unit increase in glycemia, the risk of developing coronary multi-vessel lesions increased by 4%, showing a significant correlation (p < 0.05). Subgroup analyses revealed that the impact of glycemia on multi-vessel lesions in patients with PCI varied according to gender, age, and smoking status, with the effect being more pronounced in men, older patients, and smokers。
Conclusion
Our findings establish a significant association between glycemia and the incidence of multi-vessel lesions, particularly pronounced in male patients, individuals over 45, and smokers.
In Vitro Fertilization Results of Gnrh Antagonists and Medroxyprogesterone Acetate Used to Prevent Premature Lh Surge During Ovarian Hyperstimulation
Authors: Dinç Can , Arıkan Saltuk Buğra , Özer Mustafa , Olgan Şafak 
Published: February 2024

Abstract
Objective
The aim of this study was to evaluate the effects of Medroxyprogesterone Acetate (MPA) treatment in comparison to Gonadotropin Releasing Hormone (GnRH) antagonists for the prevention of premature luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (OS) in in vitro fertilization (İVF) treatment, and their impact on developing embryos and pregnancy outcomes.
Material and Methods
Data from 757 cycles using GnRH antagonists and 756 cycles using MPA were evaluated at Akdeniz University Faculty of Medicine Assisted Reproductive Treatment Center between October 2018 and April 2022. Patient records were obtained from the electronic database of the center and analyzed for demographic data, previous treatment, features of OS treatment, and pregnancy results. All methods in this study were performed in accordance with the relevant guidelines and regulations.
Results
Patients using MPA were found to be significantly older (33.9 ± 5.6 vs. 32.6 ± 5.6, p < 0.001) and had a lower number of antral follicles (AFC) (10.7 ± 8.6 vs. 11.9 ± 10.8, p = 0.007) than those using GnRH antagonists. Both MPA (2.9%) and GnRH antagonists (2.2%) had similar effectiveness in preventing premature ovulation (p = 0.415). There was no significant difference between the two groups in terms of the number of total developed embryos (1.3 ± 1.3 vs. 1.2 ± 1.2, p = 0.765). The clinical pregnancy rates per embryo transfer (ET) were similar in the first transfers of patients using MPA and GnRH antagonists (%35.4 vs. %30.1, p = 0.074). There was no statistically significant difference between the cumulative clinical pregnancy rates per total transfer of the MPA and GnRH antagonist groups (35.3% vs. 30.1%, p = 0.077). Similarly, no significant difference was observed in the cumulative clinical pregnancy rates per patient treated after all ETs (24.1% vs. 23.2%, p = 0.269).
Conclusion
MPA was found to be effective in preventing premature ovulation during OS treatment, and the developing embryo and pregnancy outcomes of patients using MPA were similar to those using GnRH antagonists. Therefore, the use of MPA instead of GnRH antagonists during OS may be a viable alternative for patients not scheduled for fresh ET.
Comparing Chemical Transfection, Electroporation, and Lentiviral Vector Transduction to Achieve Optimal Transfection Conditions in the Vero Cell Line
Authors: Jamour Parisa , Jamali Abbas , Langeroudi Arash Ghalyanchi , sharafabad Behrouz Ebadi , Abdoli Asghar 
Published: February 2024

Abstract
Background: Transfection is an important analytical method for studying gene expression in the cellular environment. There are some barriers to efficient DNA transfection in host cells, including circumventing the plasma membrane, escaping endosomal compartmentalization, autophagy, immune sensing pathways, and translocating the nuclear envelope. Therefore, it would be very useful to introduce an optimum transfection approach to achieve high transfection efficiency in the Vero cell line.The aim of this study was to compare various transfection techniques and introduce a highly efficient method for gene delivery in the Vero cell line.
Methods: In the current study, three transfection methods were performed, including chemical transfection, electroporation, and lentiviral vector transduction, to obtain the optimum transfection conditions in the Vero cell line. Vero cells were cultured and transfected with chemical transfection reagents, electroporation, and HIV-1-based lentivectors under different experimental conditions. Transfection efficiency was assessed using flow cytometry and fluorescence microscopy to detect GFP-positive cells.
Results: Among the tested methods, TurboFect™ chemical transfection exhibited the highest efficiency. Optimal transfection conditions were achieved using 1 μg DNA and 4 µL TurboFect™ on 6×104 Vero cells.
Conclusion: TurboFect™, a cationic polymer transfection reagent, demonstrated superior transfection efficiency in Vero cells compared with electroporation and lentivirus particles and is the optimal choice for chemical transfection in the Vero cell line.
Structural Characteristics and Evolution Mechanism of Paleogene Faults in the Central Dongying Depression, Bohai Bay Basin
Authors: Zhang Ruixiang , Bai Qinglin , Wang Bing , Wang Jie , Li Yanan , Guo Mengju 
Published: February 2024

Abstract
This study used the growth index, fault activity rate and fault distance burial depth curve methods to analyze the characteristics of fault activity in the central area of Dongying depression. Using typical fault evolution and dynamic analysis to study the stages of fault evolution in the area, and using physical simulation experiments to study the mechanism and evolution process of fault formation. According to the results, the faults in the study area can be classified into four types. The Shicun fault and the pre-existing faults in the basin developed in the Paleogene Kongdian to Es4 period. Es3x and Es3z stages were characterized by strong extensional fault activities. The effect of strike-slip transformation from the Es3s to Es1 period was strengthened. The extensional fault continued to be active in Dongying period, and the strike-slip fault was basically stopped. The study area has been in the depression stage since Neogene. The physical simulation experiments show that the northern He 125 fault system is a fault combination composed of a main fault and broom-shaped branches formed by normal fault activities in the early stages and dextral strike slip processes in the late periods. The central en echelon fault system is a fault combination composed of three R fractures inherited the NE-SW basement fault and regulated by the later dextral strike-slip activities. The southern Wangjiagang fault system is a complex fault combination composed of Wangjiagang structure (P fracture) and Bamianhe structure (R fracture) developed from the Tanlu concealed branch strike-slip fault. This paper provided important reference for further research on the tectonic evolution and hydrocarbon accumulation in Dongying depression.
Robust Fully Explicit Method for Solving the Navier-Stokes Equations
Authors: Oguni Kenji , Hirobe Sayako 
Published: February 2024

Abstract
The motion of viscous fluids is described by the Navier-Stokes equations. Theinherent nonlinearity in the Navier-Stokes equations preventsus from the analyticsolutions. This paper introduces a robust fully explicit method for numericallysolving the discretized Navier-Stokes equations, applicable to various flow typeswithout tuning parameters or artificial models. The numerical analysis resultsdemonstrating the stability and the robustness of the proposedfully explicitmethod imply the discovery of the rigorous spatial integration of the Navier-Stokes equations over the subdomain uniquely defined for the discrete samplingpoints in the analysis domain. We anticipate that our findings could serve as amilestone to the comprehensive resolution of the millennium problem regardingthe Navier-Stokes equations.
Regulated pricing decisions and diagnostic test choices in personalized medicine: Navigating the implications within legal frameworks
Authors: Cui Zibin , Liu Xiangdong , Feng Zehua , Huang Zhengzong 
Published: February 2024

Abstract
Background: This study investigates the interplay between the government’s regulated pricing decisions and drug manufacturers’ diagnostic test choices in personalized medicine. The focus is on understanding the impact of government intervention on pharmaceutical companies’ strategic decisions, particularly in choosing partnerships with diagnostic firms at different levels.
Methods: A stylized analytical model was developed, employing game-theoretic principles. This approach provided a nuanced understanding of the market forces and the economic implications of these strategic decisions.
Results: The study reveals that in the absence of government-regulated pricing , drug manufacturers benefit from partnering with high-level diagnostic firms, enhancing consumer surplus and social welfare. However, when the government regulates pricing, the choice of partnering with a high-level diagnostic firm depends on specific conditions, such as low patient sensitivity to treatment failure and a low unit cost coefficient of diagnostic effort. The government’s decision to regulate prices is influenced by three key parameters: patients’ sensitivity to treatment failure, the unit cost coefficient of the diagnostic test effort, and the proportion of the price of specialized drugs in the regulated pricing.
Conclusion: The findings underscore the importance of legal frameworks in the personalized medicine industry. The absence of the government’s regulated pricing incentivizes collaborations with high-level diagnostic firms, enhancing consumer surplus and social welfare. However, government intervention in pricing makes such decisions contingent on specific conditions, requiring nuanced regulatory policies that balance the interests of patients, manufacturers, and diagnostic firms.
Learning to hear again with alternating cochlear frequency allocations
Authors: Hoof Marc van , Lambriks Lars , Heijden Kiki van der , Devocht Elke , George Erwin 
Published: February 2024

Abstract

Traditionally, the place-pitch ‘tonotopically’ organized auditory neural pathway was considered to be hard-wired. Cochlear implants restore hearing by arbitrarily mapping frequency-amplitude information. This study shows that recipients, after a long period of sound deprivation, preserve a level of auditory plasticity, enabling them to swiftly and concurrently learn speech understanding with two alternating, distinct frequency maps. During rehabilitation, subjects switched maps randomly on a daily basis, serving as their own control. After stating their preference, on average, subjects maintained their hearing performance with the legacy map over time. In contrast, subjects continued to learn and improve with their map of preference. Surprisingly, the two maps did not seem to compete for scarce neural resources. This shows a new level of flexibility in learning and long-term adaptation of the auditory system. Practically, the required novel study design halves the sample size while mitigating order effects associated with neural plasticity, benefitting sensory-oriented trials.
ARVMex: A web application for obtaining acoustic reference values for forensic studies in Spanish
Authors: López-Escobedo Fernanda , Huerta-Pacheco N. Sofía 
Published: February 2024

Abstract
Forensic speech experts using the auditory-acoustic-phonetic approach face different challenges when dealing with recordings collected under different technical conditions. We developed ARVMex tool to provide acoustic reference values to describe variation due to technical conditions in recordings. The tool employs a corpus of Spanish speakers, generating descriptive statistics based on different attributes, including speaker characteristics, different sounds, and on two technical conditions: face-to-face interviews and telephone conditions. The results indicate that, for the fundamental frequency, the mean values of the interview attribute accurately depict the behavior of each vowel by gender, whereas the mean values of the telephone attribute exhibit deviation from the general average. In relation to vowel formants, reference values per vowel, gender, and technical conditions must be established considering variations among vowels and the overall mean. The tool presented here aims to assist experts by providing insights into the variations in the measurements of acoustic properties due to technical conditions.
Elevated CA19-9 within the normal range suggest poorer prognosis in stage II colorectal cancer: a retrospective analysis of a large sample in a single center
Authors: Zhang Ruoxin , Chen Fan , Weng Junyong , Ye Zilan , Li Xinxiang 
Published: February 2024

Abstract
Objective
Carbohydrate antigen 19 − 9 (CA19-9) and carcinoembryonic antigen (CEA) serve as pivotal tumor markers in colorectal cancer (CRC). Yet, uncertainty persists regarding the prognostic significance of the two tumor markers when falling within the normal range. We attempt to compare the prognostic differences of tumor markers at different levels within the reference range.
Methods
This retrospective study scrutinized 2,167 cases of stage II CRC verified by pathology after surgery at the Fudan University Shanghai Cancer Center. Using R software to calculate the optimal critical value to compare the clinical and pathological characteristics and prognosis of different levels of tumor markers.
Results
Utilizing R software, the optimal critical value of CA19-9 was determined as 12.12 U/mL and that of CEA as 1.89 U/mL. Kaplan-Meier survival analysis unveiled that, within the normal range, relatively higher levels of CEA were linked to poorer OS [HR = 1.829 (1.280,2.989), p = 0.0033] and DFS [HR = 1.472 (1.114,1.944), p = 0.0444]. Similarly, heightened levels of CA19-9 also indicated inferior OS [HR = 1.750 (1.203,2.455), p = 0.0076] and DFS [HR = 1.361 (1.098,1.686), p = 0.0049]. Furthermore, multivariate analysis identified CA19-9 as an independent risk factor for OS (HR = 1.49,95% CI: 1.086–2.045, p = 0.014) and DFS (HR = 1.327,95% CI: 1.070–1.647, p = 0.01), while the impact of CEA on OS and DFS was not statistically significant.
Conclusion
Even within the normal range, elevated CA19-9 was associated with inferior prognosis. This work will contribute to standardizing the diagnosis and treatment of stage II CRC and provide clinicians with essential insights for chemotherapy decisions.
A Framework to Define Optimal Fallowing Programs: a Case Study of California Water System
Authors: Mirzaei Shokoufeh , Garcia Anna Maria 
Published: February 2024

Abstract
The Western region of the United States has been facing a 23-year drought, which has had a detrimental impact on California's water resources, reaching unprecedented levels. In August 2021, the United States Bureau of Reclamation announced the first-ever shortage on the Colorado River, leading to water cuts for many users. As the levels in Lake Mead and Lake Powell continued to decline in 2022, the water cuts were expanded. Industrial farming in Southern California depends on this water source for irrigation, and fallowing cropland can lead to significant water savings in a short period. By keeping cultivated land out of production during a typical growing season, farmers can reduce water usage quickly. This study proposes an optimization model to determine the optimal fallowing plan based on estimated crop water consumption, commodity prices, and other land, water, and budget constraints. To illustrate the application of the proposed optimization model, publicly available crop and weather data were used to estimate the water usage of crops in water agencies across California and to estimate optimum fallowing plans for Colorado River System and California State Water Project. The optimized fallow plans assist interested organizations in determining the best groups of crops to fallow and the payment per acre farmers may receive to achieve specific water conservation goals. The result of the optimization is compared with the current fallow rates proposed to famers.
Effects of hand catalepsy on subjective trance perception and relative parasympathetic tone in healthy volunteers during pleasant hypnotic session: a randomized controlled study
Authors: Boselli Emmanuel , Radoykov Stéphane , Paqueron Xavier , Virot Claude 
Published: February 2024

Abstract
Purpose: This study was designed to evaluate the effects on hand catalepsy on parasympathetic tone assessed using Analgesia/Nociception Index (ANI) and on subjective rating of absorption, dissociation, and time perception among healthy volunteers.
Methods: This was a randomized controlled trial including participants to a medical hypnosis congress in France. Ninety volunteers were randomized in two arms, all receiving a fifteen-minute positive hypnotic trance, with or without hand catalepsy. The relative parasympathetic tone assessed by ANI (Analgesia/Nociception Index), heart rate and respiratory rate were recorded at different times of the study protocol. The actual duration of the hypnotic session, calculated from eye closing to eye opening, was also recorded. At the end of the hypnotic trance, participants subjectively rated their level of absorption and dissociation on a 0-10 scale. They were also asked to estimate the duration of the hypnotic session from eye closing to eye opening.
Results: In total, ninety subjects were included in the study. One subject was excluded because of deviation in the protocol standard, leaving eighty-nine subjects for analysis. Subject characteristics were similar between groups.
There was a statistically different increase in ANI and decrease in both heart rate and respiratory rate over time with no difference with or without hand catalepsy. There was no statistically significant difference in absorption and dissociation subjective scales between groups. The median [Q1-Q3] actual duration of hypnotic sessions was similar between the catalepsy and the control groups (9 [8-10] min vs. 8 [7-10] min, respectively). However, subjects in the catalepsy group estimated a longer duration of the hypnotic session (12 [10-15] min) than in the control group (10 [5-10] min) with a mean ± SD overestimation of 3 ± 4 min (p<0.001).
Conclusion: Parasympathetic comfort increased during the hypnotic trance with no difference between groups. However, adding a hand catalepsy to a pleasant hypnotic trance did not appear to increase feelings of absorption or dissociation but created time distortion on the longer side that could be useful in some clinical settings. Nevertheless, further study is still needed to determine more precisely the physiological and psychological effects on hand catalepsy during the hypnotic trance.
Temporal variations of shorebird (Charadriiformes) community and its diversity at Muttukadu backwaters - a wintering site in the southeast coast of India
Authors: N Ramya Shree , E Malathi 
Published: February 2024

Abstract
Shorebirds are group of migratory aquatic birds that spend time in coastal habitats such as tidal mudflats, sand bars, intertidal zones, and beaches. This groundbreaking study was conducted to assess the shorebird population and its diversity during September 2021 to September 2023 using total and block count method on the southeast coastline of India with a study site located at Muttukadu backwaters (12.8006oN latitude and 80.2363o E longitude), Chengalpet district of Tamil Nadu. The present study recorded 41 shorebird species from Muttukadu backwaters within the order of Charadriiformes with five families (Burhinidae, Recurvirostridae, Charadriidae, Scolopacidae, Laridae). The highest mean diversity of shorebirds was observed in the monsoon season. The mean abundance of shorebirds was higher in the post monsoon and followed by monsoon period due to the increased abundance of migratory species. The data from rarefaction curve shows that post monsoon and monsoon possess highest species richness than premonsoon and summer. This long-term survey of wintering shorebirds in the study area can be used for proposing the habitat management strategies.