bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of children with favorable histology Wilms tumor with extrapulmonary metastases: A report from the COG studies AREN0533 and AREN03B2 and NWTSG study NWTS‐5
Authors: Benedetti Daniel J. , Varela Carly R. , Renfro Lindsay A. , Tornwall Brett , Dix David B. , Ehrlich Peter F. , Glick Richard D. , Kalapurakal John , Perlman Elizabeth , Gratias Eric , Seibel Nita L. , Geller James I. , Khanna Geetika , Malogolowkin Marcio , Grundy Paul , Fernandez Conrad V. , Dome Jeffrey S. , Mullen Elizabeth A. 
Published: November 2023

AbstractBackgroundPatients with stage IV favorable histology Wilms tumor (FHWT) with extrapulmonary metastases (EPM) constitute a small subset of patients with FHWT. Because of their rarity and heterogeneity, optimal FHWT treatment is not well understood. Children’s Oncology Group protocol AREN0533 assigned patients with FHWT and EPM to intensified chemotherapy, regimen M, after initial DD‐4A chemotherapy. To improve understanding of prognostic factors and best therapies, experiences of patients with EPM on AREN0533, as well as on protocols AREN03B2 and NWTS‐5, were reviewed.MethodsCombined outcomes for patients with EPM from NWTS‐5, AREN0533, and AREN03B2 were determined. Those treated on AREN0533 were compared with those treated on NWTS‐5. Prognostic factors were explored in the pooled cohort.ResultsForty‐seven patients with FHWT with EPM enrolled on AREN0533, 37 enrolled on NWTS‐5, and 64 were followed only on AREN03B2. The pooled cohort of all 148 patients demonstrated a 4‐year event‐free survival (EFS) of 77.3% (95% CI, 70.8–84.4) and 4‐year overall survival of 88.9% (95% CI, 83.9–94.2). Four‐year EFS of patients with EPM treated on AREN0533 was 76.0% (95% CI, 64.6–89.4) vs 64.9% (95% CI, 51.7–82.2) on NWTS‐5; hazard ratio, 0.64, p = .26; no difference in overall survival was observed. Increasing linear age and slow incomplete lung response were associated with worse EFS in a pooled cohort.ConclusionsOutcomes for patients with EPM are among the lowest for children with FHWT. Further trials with standardized surgical and radiation treatment to metastatic sites, and prospectively collected biologic and treatment details are needed.Clinical trial registrationClinical Trials.gov identifiers: NCT00379340, NCT00898365, and NCT00002611.
Guideline‐directed medical therapy in severe heart failure with reduced ejection fraction: An analysis from the HELP‐HF registry
Authors: Tomasoni Daniela , Pagnesi Matteo , Colombo Giada , Chiarito Mauro , Stolfo Davide , Baldetti Luca , Lombardi Carlo Mario , Adamo Marianna , Maggi Giuseppe , Inciardi Riccardo Maria , Loiacono Ferdinando , Maccallini Marta , Villaschi Alessandro , Gasparini Gaia , Montella Marco , Contessi Stefano , Cocianni Daniele , Perotto Maria , Barone Giuseppe , Merlo Marco , Cappelletti Alberto Maria , Rosano Giuseppe , Sinagra Gianfranco , Pini Daniela , Savarese Gianluigi , Metra Marco 
Published: November 2023

AbstractAimPersistent symptoms despite guideline‐directed medical therapy (GDMT) and poor tolerance of GDMT are hallmarks of patients with advanced heart failure (HF) with reduced ejection fraction (HFrEF). However, real‐world data on GDMT use, dose, and prognostic implications are lacking.Methods and resultsWe included 699 consecutive patients with HFrEF and at least one ‘I NEED HELP’ marker for advanced HF enrolled in a multicentre registry. Beta‐blockers (BB) were administered to 574 (82%) patients, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers or angiotensin receptor–neprilysin inhibitors (ACEi/ARB/ARNI) were administered to 381 (55%) patients and 416 (60%) received mineralocorticoid receptor antagonists (MRA). Overall, ≥50% of target doses were reached in 41%, 22%, and 56% of the patients on BB, ACEi/ARB/ARNI and MRA, respectively. Hypotension, bradycardia, kidney dysfunction and hyperkalaemia were the main causes of underprescription and/or underdosing, but up to a half of the patients did not receive target doses for unknown causes (51%, 41%, and 55% for BB, ACEi/ARB/ARNI and MRA, respectively). The proportions of patients receiving BB and ACEi/ARB/ARNI were lower among those fulfilling the 2018 HFA‐ESC criteria for advanced HF. Treatment with BB and ACEi/ARB/ARNI were associated with a lower risk of death or HF hospitalizations (adjusted hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.48–0.84, and HR 0.74, 95% CI 0.58–0.95, respectively).ConclusionsIn a large, real‐world, contemporary cohort of patients with severe HFrEF, with at least one marker for advanced HF, prescription and uptitration of GDMT remained limited. A significant proportion of patients were undertreated due to unknown reasons suggesting a potential role of clinical inertia either by the prescribing healthcare professional or by the patient. Treatment with BB and ACEi/ARB/ARNI was associated with lower mortality/morbidity.
Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus
Authors: Kadlec Sarah M. , Backe Will J. , Erickson Russell J. , Hockett J. Russell , Howe Sarah E. , Mundy Ian D. , Piasecki Edward , Sluka Henry , Votava Lauren K. , Mount David R. 
Published: November 2023

Abstract
Seven-day sublethal toxicity tests were performed with the freshwater invertebrates Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus to determine the effects of per- or polyfluorinated alkyl substances (PFAS) of varying chain length within four classes: perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkyl sulfonic acids (PFSAs), perfluoroalkane sulfonamides, and fluorotelomer sulfonic acids. In general, toxicity increased with increasing chain length, but the slopes of these relationships varied markedly by species and chemical class. The toxicity of individual PFCAs was similar among species. The toxicity of PFSAs was similar to PFCAs for C. dubia and H. azteca, whereas PFSAs were much more toxic to C. dilutus, with median effect concentrations (EC50s) as low as 0.022 mg perfluorooctane sulfonate (PFOS)/L and 0.012 mg perfluorononane sulfonate (PFNS)/L. Despite the high sensitivity to PFOS and PFNS, C. dilutus was not very sensitive to structurally similar fluorotelomer sulfonates (6:2 and 8:2). Perfluoroalkane sulfonamides were the most toxic class tested among all species (e.g., EC50s of 0.011 and 0.017 mg perfluorooctane sulfonamide/L for C. dilutus and H. azteca, respectively). The differences in toxicity among species and chemical classes suggest that mechanisms of PFAS toxicity may differ as a function of both. Environ Toxicol Chem 2024;43:359–373. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.
Study on the influence of air supply and smoke exhaust on full transverse exhaust of long highway tunnel
Authors: Peng Min , Zhou Yun , Ming Yuyang , Song Chunxiao , He Kun , Wu Zhenkun , Zhu Guoqing 
Published: November 2023

AbstractThis study investigated the efficacy of the full transverse exhaust method for smoke extraction in tunnel fires. It examines factors such as the number and layout of air supply and exhaust outlets, analyzing their impact on smoke spread, tunnel temperature, visibility, and airflow. The results demonstrate that the full transverse exhaust method effectively controls smoke emissions in raised highway tunnels. It limits smoke spread, reduces tunnel temperature, and effectively controls the fire‐affected area. The number and layout of outlets significantly influence smoke dispersion, with fewer exhaust outlets providing better smoke control and optimizing the tunnel environment. However, insufficient outlets disrupt gas flow stability. The position of exhaust outlets affects smoke distribution, and caution is advised to prevent directing fresh air flow toward the fire. Opening an equal number of exhaust outlets on one side of the fire source yields superior smoke extraction results, reducing tunnel ceiling temperatures and minimizing risks to personnel and structures. Though stabilization may take longer, this configuration proves advantageous. The study offers valuable insights and practical guidelines for implementing the full transverse smoke control method in real‐world scenarios.
The effect of solution plasma treatment on the microbial safety and quality characteristics of albumen
Authors: Akarca Gökhan , Avci Ayşin Kahraman 
Published: November 2023

AbstractThe aim of this study was to make eggs microbially safe and increase their durability without damaging the functional properties of the albumen and preserving the solubility of its proteins as much as possible by the solution plasma technique. The pH, Brix, density, and viscosity values of samples decreased during treatment (p < .05 except pH). Although the L* and a* values of both the albumen and egg foam decreased, the b*, hue angle, and chroma values of both increased during treatment. The L* and a* values of the albumen decreased by 7.01 and 1.89 units, and the values of the egg foam decreased by 10.93 and 1.03 units, respectively. At the end of the treatment, foaming capacity and foam stability were decreased by 25% and 21.42%, respectively. Foaming capacity values obtained as a result of this treatment were higher and foam stability values were lower compared to the values obtained in pasteurization of eggs by heat treatment. The count of the two pathogenic bacteria inoculated into the albumen decreased during the treatment (p < .05), the count of Salmonella Enteritidis decreased to 0, and the count of Staphylococcus aureus decreased by 1.09 log cfu/g at the end of the treatment. Compared to current heat treatments, solution plasma treatment caused significantly less adverse effects on albumen quality characteristics. In particular, the foaming properties of the albumen were much less affected by this method and remained at higher values compared to the values achieved by other methods. The treatment also produced a microbiologically safer product.
Selection of the most suitable pretreatment method by PROMETHEE for baker's yeast production wastewater in Microbial Fuel Cell
Authors: Durna Pişkin Elif , Genç Nevim 
Published: November 2023

AbstractBACKGROUNDThe high organic load and low biodegradability of the effluent from baker's yeast production limit its use as a substrate in microbial fuel cell (MFC) systems. In this study, baker's yeast production wastewater was used as a substrate in the anode chamber to assess the impact of various pretreatment methods [dilution, microwave (MW), acidic‐thermal, basic‐thermal and ultrasound (US)] on electricity generation and waste treatment. Additionally, azo dye was used as an electron acceptor at the cathode. Power density and coulomb efficiency were evaluated for electricity generation, and chemical oxygen demand (COD) removal and azo dye removal parameters were evaluated for treatability.RESULTSThe maximum power densities obtained were 83.53, 46.54, 19.41, 67.40, 41 and 33 mW m−2 for MW, acidic thermal, alkaline‐thermal and US pretreatments, diluted raw and raw wastewater, respectively. To determine the most suitable pretreatment method, PROMETHEE was performed using the criteria of maximum power density, COD removal, azo dye removal, coulombic efficiency and pretreatment cost. The most suitable method was found to be MW pretreatment. The order of the alternatives was found to be MW > US > acidic/thermal > diluted raw > raw > alkaline/thermal. With the MW pretreatment, 81.34% azo dye removal, 5 g L−1 COD removal, 0.27% coulombic efficiency and €0.284 L−1 pretreatment cost were obtained.CONCLUSIONThe most suitable pretreatment method to be applied to wastewater for the treatment of baker's yeast production wastewater and high energy production was determined as MW using the PROMETHEE approach. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Effect of sugammadex administration on neural tube development in 48‐h chick embryos
Authors: Büyükerkmen Elif , Atay Emre , Firat Fatma , Yüksek Ahmet , Bilir Abdülkadir , Albaş Kurt Gülan , Saritaş Alperen 
Published: November 2023

AbstractSugammadex is a new generation drug that has led to significant changes in the practice of anesthesia. However, its effects on fetal development are not yet fully known. The aim of this study is to investigate the teratogenic effects of sugammadex on neural tube and embryonic development in early chick embryos. In this study, 50 0‐day fertile specific non‐pathogenic (SPF) eggs were used. Fifty eggs were divided into 5 different groups, each consisting of 10 pieces. While no substance was given to the control group at the 28th hour of the study, 4 different doses of sugammadex were administered to the experimental groups, respectively 2, 4, 8, 16 mg/kg. Cranio‐caudal lengths of embryos, somite numbers, average number of argyrophilic nucleolar regulatory regions (AgNOR) per nucleus, total AgNOR area/total nuclear area (TAA/NA) ratios, Caspase‐3 H‐Score results, and presence of neural tube defect were compared among the groups. While the mean cranio‐caudal lengths, somite counts, TAA/NA ratios and AgNOR counts of the embryos were found to be statistically significantly lower than the control group, Caspase‐3 H‐Score mean results were found to be significantly higher (p < .05). In addition, it was observed that there was an increase in neural tube patency and developmental delay. As a result, sugammadex crossing the placenta was revealed to increase the release of proapopitotic molecules and disrupt the developmental stages of embryos. Thus, it was determined that sugammadex in increased developmental delay and incidence of neural tube defects in early chick embryos with increased dose dependent. Despite these results, the effects of sugammadex on fetal development in in vivo and in vitro environments should be studied with further studies.Research Highlights
Sugammadex is a new generation drug that has led to significant changes in the practice of anesthesia. However, its effects on fetal development are not yet fully known. It has been observed that different doses of sugammadex increase the risk of neural tube defect development on chick embryos and slow the embryo development in a dose‐dependent manner.
Maximising the potential of academic–practitioner collaborations in international development
Authors: Brunese Priyanka , Lee Min K. , Bessenbacher Ann , Raman Arvind , Yih Yuehwern 
Published: November 2023

AbstractA call to action has been issued for cross‐sector partnerships such as academic–practitioner collaborations to develop evidence‐based solutions to address development challenges. This study investigated correlations between factors such as motivation, involvement in co‐creation of research, usability of research outputs and past partnering experiences with the future participation in such collaborations. Using survey data from members of the LASER PULSE Consortium, we not only present empirical evidence on the mismatch of expectations between academics and practitioners but also recommend a framework to maximise the potential of such collaborations by understanding value propositions and managing partnering experience.
Activation of Toll‐like receptor 3 inhibits HIV infection of human iPSC‐derived microglia
Authors: Wang Peng , Liu Jin‐Biao , Wang Xu , Meng Feng‐Zheng , Xiao Qian‐Hao , Liu Lu , Zhu Jian , Hu Wen‐Hui , Ho Wen‐Zhe 
Published: November 2023

AbstractAs a key immune cell in the brain, microglia are essential for protecting the central nervous system (CNS) from viral infections, including HIV. Microglia possess functional Toll‐like receptor 3 (TLR3), a key viral sensor for activating interferon (IFN) signaling pathway‐mediated antiviral immunity. We, therefore, studied the effect of poly (I:C), a synthetic ligand of TLR3, on the activation of the intracellular innate immunity against HIV in human iPSC‐derived microglia (iMg). We found that poly (I:C) treatment of iMg effectively inhibits HIV infection/replication at both mRNA and protein levels. Investigations of the mechanisms revealed that TLR3 activation of iMg by poly (I:C) induced the expression of both type I and type III IFNs. Compared with untreated cells, the poly (I:C)‐treated iMg expressed significantly higher levels of IFN‐stimulated genes (ISGs) with known anti‐HIV activities (ISG15, MxB, Viperin, MxA, and OAS‐1). In addition, TLR3 activation elicited the expression of the HIV entry coreceptor CCR5 ligands (CC chemokines) in iMg. Furthermore, the transcriptional profile analysis showed that poly (I:C)‐treated cells had the upregulated IFN signaling genes (ISG15, ISG20, IFITM1, IFITM2, IFITM3, IFITM10, APOBEC3A, OAS‐2, MxA, and MxB) and the increased CC chemokine signaling genes (CCL1, CCL2, CCL3, CCL4, and CCL15). These observations indicate that TLR3 is a potential therapy target for activating the intracellular innate immunity against HIV infection/replication in human microglial cells. Therefore, further studies with animal models and clinical specimens are necessary to determine the role of TLR3 activation‐driven antiviral response in the control and elimination of HIV in infected host cells.
IFIT3 inhibits Epstein‐Barr virus reactivation via upregulating innate immunity
Authors: Zhang Wentao , Jiang Mingjuan , Liao Xuefei , Li Yanling , Xin Shuyu , Yang Li , Xin Yujie , Umar Abdulrahim , Lu Jianhong 
Published: November 2023

AbstractEpstein‐Barr virus (EBV), a member of the γ‐herpesvirus family, can establish latent infection in B lymphocytes and certain epithelial cells after primary infection. Under certain circumstances, EBV can enter into lytic replication. However, the regulation of EBV latent‐lytic infection remains largely unclear. The important immune molecule, interferon‐induced protein with tetratricopeptide repeats 3 (IFIT3), was upregulated in EBV latently infected cells. When the lytic replication of EBV was induced, the expression of IFIT3 was further increased. In turn, IFIT3 overexpression dramatically inhibited the lytic replication of EBV, while IFIT3 knockdown facilitated EBV lytic replication. Moreover, upon the lytic induction, the ectopic IFIT3 expression promoted the activation of the interferon (IFN) pathway, including the production of IFN‐stimulated genes (ISGs), IFNB1, and the phosphorylation of IFN‐regulatory factor 3 (IRF3). In contrast, the depletion of IFIT3 led to decreased ISGs and IFNB1 expression. Mechanically, IFIT3 inhibited EBV lytic replication through IFN signaling. This study revealed that the host innate immune‐related factor IFIT3 played an important role in regulating EBV latent‐lytic homeostasis. The results implied that EBV has evolved well to utilize host factors to maintain latent infection.
Recent advances in treating female genital human papillomavirus related neoplasms with topical imiquimod
Authors: Borella Fulvio , Gallio Niccolò , Mangherini Luca , Cassoni Paola , Bertero Luca , Benedetto Chiara , Preti Mario 
Published: November 2023

AbstractHuman papillomavirus (HPV) encompasses a group of viruses that infect the skin and mucous membranes. In the presence of certain factors, persistent infection with high‐risk HPVs can trigger a process of neoplastic transformation. Imiquimod is a topical agent that acts as a Toll‐like receptor 7/8 agonist, stimulating the innate and adaptive immune system to exert antitumor and antiviral effects. It has been approved for the treatment of various skin conditions, however, its efficacy and safety in the management of HPV‐related‐neoplasms of the lower genital tract, such as vulvar, vaginal, and cervical neoplasia, are still under investigation. This review summarizes the current evidence on the use of imiquimod for the treatment of HPV‐induced lesions of the female lower genital tract, focusing on its indications, mechanisms of action, outcomes, and predictors of response.
Quality attributes and functional properties of whole wheat bread baked from frozen dough with the addition of enzymes and hydrocolloids
Authors: He Ni , Xia Mingwei , Zhang Xia , He Min , Li Lin , Li Bing 
Published: November 2023

AbstractBACKGROUNDThe increased demand for healthy and standardized bread has led to a demand for an efficient and promising dough improver, of natural origin, to reduce the deterioration of whole wheat bread baked from frozen dough caused by the high levels of dietary fiber and by freezing treatment. In this study, the combined effects of xylanase (XYL), lipase (LIP), and xanthan gum (XAN) on the quality attributes and functional properties of whole wheat bread baked from frozen dough were evaluated.RESULTSThe optimal combination, which contained XYL (0.12 g kg−1), LIP (0.25 g kg−1), and XAN (3.1 g kg−1), was obtained using response surface methodology (RSM). The addition of the optimal combination endowed frozen dough bread with a higher specific volume, softer texture, better brown crumb color, and greater overall acceptability. The optimal combination had no adverse impact on the volatile organic compounds (VOCs) of frozen dough bread. In terms of the functional properties of bread, the water‐holding capacity (WHC), oil‐holding capacity (OHC), and swelling capacity (SWC) of dietary fiber in frozen dough bread decreased in the presence of the optimal combination, whereas the glucose adsorption capacity (GAC) did not affect them. Correspondingly, the in vitro digestive glucose release was not significantly different between the control group and the optimal combination group after frozen storage.CONCLUSIONThe optimal combination could improve the quality attributes and functional properties of whole wheat bread baked from frozen dough effectively, thereby increasing consumption. © 2023 Society of Chemical Industry.
Chemical composition analysis of Angelica sinensis (Oliv.) Diels and its four processed products by ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry combining with nontargeted metabolomics
Authors: Wang Kangyu , Liu Xiaokang , Cai Guangzhi , Gong Jiyu , Guo Yunlong , Gao Wenyi 
Published: November 2023

Angelica sinensis (Oliv.) Diels. has been used for women to enrich the blood, prevent and treat blood deficiency syndrome in Traditional Chinese Medicine for thousands of years. Wine‐processed Angelica sinensis, soil‐processed Angelica sinensis, oil‐processed Angelica sinensis, and charred‐processed Angelica sinensis are the most significant four processed products used in Chinese clinic. However, there have been few studies aimed at comparing their chemical differences. Ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry combining with nontargeted metabolomics was applied to investigate the diversity of processed products of Angelica sinensis. A total of 74 compounds with the variable importance in the projection value more than 1.5 and P less than 0.05 in ANOVA were highlighted as the compounds that contribute most to the discrimination of Angelica sinensis and four processed products. The results showed the metabolic changes between Angelica sinensis and its four processed products, there were 19 metabolites, 3 metabolites, 6 metabolites, and 45 metabolites were tentatively assigned in soil‐processed Angelica sinensis, wine‐processed Angelica sinensis, oil‐processed Angelica sinensis, and charred‐processed Angelica sinensis, respectively. These results suggested that the proposed metabolomics approach was useful for the quality evaluation and control of processed products of Angelica sinensis.