bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Surgical Therapy for Patients with Stage IA2–IIB1 Cervical
Cancer
Authors: Fehm Tanja , Beckmann Matthias W. , Mahner Sven , Denschlag Dominik , Brucker Sara , Hillemanns Peter , Tempfer Clemens ,   for the Uterus Commission of the AGO and the AGO Working Group
Published: October 2023

AbstractThe presentation of the results of the prospective randomized international multicenter study AGO-OP.8 – CCTG CX.5 – SHAPE at the annual conference of the American Society of Clinical
Oncology (ASCO) in 2023 will affect the surgical treatment of early-stage cervical cancer. In the SHAPE study, simple total hysterectomy (experimental arm) was found to be non-inferior to
radical hysterectomy (standard arm) to treat patients with early-stage cervical cancer (FIGO stages [2018] IA2 – IB1 ≤ 2 cm with an infiltration depth of < 1 cm); after 3 yearsʼ follow-up
the pelvic recurrence rate was 2.52% (experimental arm) compared to 2.17% (standard arm) with no statistically significant difference with regards to recurrence-free survival and overall
survival rates. After weighing up the results of the SHAPE study published at the conference, the Uterus Organ Commission of AGO is of the opinion that, in addition to the use of radical
hysterectomy to treat patients with invasive cervical cancer which is FIGO stage IA2 – IB1 ≤ 2 cm with an infiltration depth of < 1 cm, simple total hysterectomy may also be considered
for primary surgical therapy on a case-by-case basis after suitable explanation of the associated risks. It will be necessary to wait for the data of the full publication before discussing
whether this approach should be included in official guidelines and defining it as a new therapy standard.
Hyperostosis of the Clavicle as a Cardinal Symptom for Sapho Syndrome
– Presentation and Discussion of a Clinical Case
Authors: Andresen Julian Ramin , Reinke Justyna , Radmer Sebastian 
Published: October 2023

AbstractSAPHO syndrome comprises a broad clinical spectrum and is based on inflammatory
osteitis with or without association to a dermatological affection. A young man
with chronic recurrent osteomyelitis (CRMO) of the right clavicle as a cardinal
symptom of SAPHO syndrome is reported on. Whole-body MRI has proven effective
for focal detection and assessment of local activity of a possible multifocal
manifestation of CRMO. Multiple medication with NSAIDs, a bisphosphonate,
vitamin D substitution and antibiosis resulted in extensive remission of
symptoms. Biologicals can also be used if there is no effect. The terminology of
chronic nonbacterial osteomyelitis (CNO) in connection with the SAPHO syndrome
is discussed.
Treatment of dyspeptic symptoms with YamatoGast. A non-interventional study of a registered traditional herbal Rikkunshito extract product from Japanese Kampo Medicine in routine practice in Germany
Authors: Reißenweber-Hewel Heidrun , Pehl Christian , Cameron Silke , Thomsen Jörn , Röschmann-Doose Kristina 
Published: October 2023

Abstract
Introduction Dyspeptic symptoms belong to the most frequent reasons to seek medical advice and are a burden both for the individual affected and the healthcare system. In Japan, the traditional herbal Kampo prescription rikkunshito has proven benefit for this indication.
Methods In a prospective, multicentre, non-interventional study (NIS), the effectiveness, safety, and tolerability of a two-week treatment with the registered rikkunshito extract product YamatoGast was assessed in German patients with an acute episode of dyspeptic symptoms of functional origin under real-world conditions. The primary endpoint was the responsiveness to treatment assessed by the overall treatment effect (OTE) score. Secondary endpoints were the change in severity of dyspeptic symptoms and the change in quality of life (QoL). Safety evaluation was based on reported adverse drug reactions, drug compliance, and ratings of tolerability by physicians and patients.
Results Sixty-six patients were enrolled (mean age 48.9 years, 74% females). The treatment was well tolerated and highly beneficial, as expressed by pronounced responder rates of 78.9% for the primary endpoint OTE. All secondary endpoints were also met. The severity of dyspeptic symptoms significantly improved by 62–77% compared to baseline, confirmed by a remarkable improvement of QoL. Significant symptom relief started from the third day of treatment onwards.
Conclusion In this non-interventional study, two-week treatment with YamatoGast resulted in a significant improvement of dyspeptic symptoms and was associated with high patient response and satisfaction. YamatoGast was confirmed as a safe and clinically relevant therapeutic option for patients suffering upper gastrointestinal complaints in routine practice.
Recurrent Non-islet Cell Tumor Hypoglycemia Secondary to Hepatocellular Carcinoma: Case Report and Literature Review
Authors: He Dan , Gong Hongpeng , Pan Jie , Zhu Fangchao , Jiang Xiaofen , Su Huang 
Published: October 2023

Abstract
Rationale Non-islet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome caused by tumors other than insulinoma that is primarily due to excessive production of insulin-like growth factor-II (IGF-II). The prevalence of NICTH is likely underestimated because of a lack of clinical recognition.
Patient Concerns A 41-year-old male with massive malignant liver tumors presented with recurrent severe hypoglycemia, weight loss, and liver cirrhosis.
Diagnosis NICTH related to IGF-II produced by hepatocellular carcinoma was diagnosed based on clinical symptoms, biochemical tests, and elevated IGF-II/IGF-I ratio.
Intervention Initial treatment with intravenous glucose and parenteral nutrition showed limited efficacy. Glucocorticoids and recombinant human growth hormone led to progressive improvement in blood glucose levels.
Outcome Due to extensive tumor burden and liver failure, surgical resection was not feasible, and the patient ultimately succumbed to refractory hypoglycemia and passed away in two weeks.
Lessons Early recognition and diagnosis of NICTH are crucial in patients with recurrent hypoglycemia and large tumors. Surgical resection is the preferred treatment option, but supportive care and pharmacological interventions, such as glucocorticoids and growth hormone, can help manage refractory hypoglycemia. Further research is needed to explore novel treatment options, including anti-IGF-I and -IGF-II neutralizing antibodies.
Structured Reporting of Head and Neck Sonography Achieves Substantial
Interrater Reliability
Authors: Weimer Johannes Matthias , Künzel Julian , Ernst Benjamin Philipp , Dörsching Carla , Bozzato Alessandro , Gabrielpillai Jennis , Becker Sven , Froelich Matthias Frank , Kramer Benedikt , Sproll Christoph , Schapher Mirco , Goncalves Miguel , Mansour Naglaa , Hofauer Benedikt , Sommer Wieland H , von Scotti Felix 
Published: October 2023

Abstract
Purpose Ultrasound examinations are often criticized for having higher
examiner dependency compared to other imaging techniques. Compared to free-text
reporting, structured reporting (SR) of head and neck sonography (HNS) achieves
superior time efficiency as well as report quality. However, there are no
findings concerning the influence of SR on the interrater reliability (IRR) of
HNS.
Materials and Methods Typical pathologies (n=4) in HNS were
documented by video/images by two certified head and neck ultrasound
instructors. Consequently, structured reports of these videos/images
were created by n=9 senior physicians at departments of otolaryngology
or maxillofacial surgery with DEGUM instructors on staff. Reports (n=36)
were evaluated regarding overall completeness and IRR. Additionally, user
satisfaction was assessed by a visual analog scale (VAS).
Results SR yielded very high report completeness (91.8%) in all
four cases with a substantial IRR (Fleiss‘ κ 0.73). Interrater
agreement was high at 87.2% with very good user satisfaction (VAS
8.6).
Conclusion SR has the potential to ensure high-quality examination reports
with substantial comparability and very high user satisfaction. Furthermore, big
data collection and analysis are facilitated by SR. Therefore, process quality,
workflow, and scientific output are potentially enhanced by SR.
Total Knee Arthroplasty in the Valgus Knee
Authors: Mannino Angelo , Weinberg Maxwell E. , Scuderi Giles R. 
Published: October 2023

AbstractAn estimated 10 to 15% of total knee arthroplasties (TKAs) are implanted for a diagnosis of arthritis when a valgus deformity is present. There are various techniques and considerations that must be considered for a successful TKA in a patient with a valgus deformity. This article provides a detailed summary of the anatomy, pathology, bone preparation, soft tissue management, implant selection, and complications when performing a TKA in a patient with valgus deformity.
Preparation and Carbocupration–Silylation of Allyl Propiolates: Vicinal Functionalization To Form Polysubstituted (E)-Vinylic Silanes
Authors: Snowden Timothy S. , Massey Cameron D. , Jennings Michael P. 
Published: October 2023

AbstractThe preparation and TMSOTf-mediated catalytic carbocupration–silylation of allylic propiolates has been investigated, expanding on previous syntheses of a variety of β-alkyl- and β-aryl-substituted vinylsilanes from an ethyl propiolate precursor. With few exceptions, the series of synthesized O-allyl (E)-vinylsilanes has been isolated in high yields (61–89%) with exceptional diastereoselectivities (E/Z >20:1). Additionally, we demonstrated a novel LDA-initiated, TMSCl-mediated Ireland–Claisen rearrangement of a representative allylic ester.
EUS-guided laser lithotripsy for pancreatic duct stones after failed conventional pancreatic endotherapy
Authors: Emmanuel James , Hsin Deborah Chew Chia , Bt Wan Abdullah Wan Zaharatul Ashikin , See Lee Tiong 
Published: October 2023

AbstractThe central dogma of pain in patients with chronic pancreatitis revolves around the pathophysiology of ductal hypertension owing to stones that obstruct the pancreatic duct. Conventional modalities available to decompress the pancreatic duct are occasionally limited by failed selective pancreatic duct cannulation during endoscopic retrograde cholangiopancreatography. We describe a novel endoscopic approach of EUS-guided laser lithotripsy to assist in pancreatic duct (PD) stone fragmentation in two symptomatic patients with underlying chronic pancreatitis who had failed PD cannulation and extracorporeal shock wave lithotripsy (ESWL). In both cases, a 365-micrometer LightTrail TracTip Holmium laser fiber was advanced within a 19G endoscopic ultrasound aspiration needle (Expect Slimline (SL), Boston Scientific, Marlborough, Massachusetts, United States) under endoscopic ultrasound (EUS) guidance to fragment the PD stones. There were no procedure-related complications encountered and follow-up after 1 month of the procedure revealed significant reduction in abdominal pain scores. To the best of our knowledge, these are the first reported cases of EUS-guided laser lithotripsy performed for PD stones. Our approach of performing laser lithotripsy under EUS guidance obviates the need for an ESWL procedure; however, it is technically more challenging and requires precision to avoid injury to the pancreas. Further prospective studies are required to evaluate the safety and efficacy of this novel approach and its applicability as either a rescue procedure or in tandem with conventional pancreatic endotherapy modalities.
Intraoperative Wound Lavage System for Deep Neck Infection: A Retrospective Cohort Study
Authors: Abdul-Hadi Soraya , Perez Francis Beauchamp , Pascual-Marrero Jeamarie 
Published: October 2023

Abstract
Introduction Multiple solutions are currently used to cleanse a deep neck infection (DNI), and a variety of devices are available to deliver wound irrigation solutions. An essential difference between these devices is the pressure that the irrigation solution exerts over the wound tissue.
Objective To compare low-pressure and high-pressure irrigation delivery systems for wound cleansing in DNI.
Methods we designed a retrospective cohort study and reviewed the medical records of patients operated on due to DNI from June 2016 to December 2017 at our institution. One cohort included patients treated with an intraoperative irrigation method that exerts low pressure over the irrigated tissue, and the other cohort, to a system capable of generating higher pressure. The Pearson Chi-squared test was used to analyze the data.
Results A total of 42 patients whose ages ranged from 16 months to 72 years were included. The low-pressure irrigation system was used in 18 patients, and the high-pressure system was used in 24 patients. No statistical differences were observed regarding the irrigation methods, the complexity of the DNI, and the overall outcomes.
Conclusions The present is the first study in which low- and high-pressure systems for wound lavage were evaluated in the treatment of DNI. When comparing these methods, we did not find one to be superior to the other; however, the additional cost associated with the high-pressure devices may not justify their in head and neck procedures.
Effect of Speaking Valves on Tracheostomy Decannulation
Authors: Eichar Bradley W. , Kaffenberger Thomas M. , McCoy Jennifer L. , Padia Reema K. , Muzumdar Hiren , Tobey Allison B. J. 
Published: October 2023

Abstract
Introduction Despite several pediatric tracheostomy decannulation protocols there remains tremendous variability in practice. The effect of tracheostomy capping on decannulation has been studied but the role of speaking valves (SVs) is unknown.
Objective Given the positive benefits SVs have on rehabilitation, we hypothesized that SVs would decrease time to tracheostomy decannulation. The purpose of the present study was to evaluate this in a subset of patients with chronic lung disease of prematurity (CLD).
Methods A retrospective chart review was performed at a tertiary care children's hospital. A total of 105 patients with tracheostomies and CLD were identified. Data collected included demographics, gestational age, congenital cardiac disease, airway surgeries, granulation tissue excisions, SV and capping trials, tracheitis episodes, and clinic visits. Statistics were performed with logistic and linear regression.
Results A total of 75 patients were included. The mean gestational age was 27 weeks (standard deviation [SD] = 3.6) and the average birthweight was 1.1 kg (SD = 0.6). The average age at tracheostomy was 122 days (SD = 63). A total of 70.7% of the patients underwent decannulation and the mean time to decannulation (TTD) was 37 months (SD = 19). A total of 77.3% of the patients had SVs. Those with an SV had a longer TTD compared to those without (52 versus 35 months; p = 0.008). Decannulation was increased by 2 months for every increase in the number of hospital presentations for tracheitis (p = 0.011).
Conclusion The present study is the first, to our knowledge, to assess the effect of SVs on tracheostomy decannulation in patients with CLD showing a longer TTD when SVs are used.
Ethical Considerations in Neuroprognostication Following Acute Brain Injury
Authors: Lissak India A. , Edlow Brian L. , Rosenthal Eric , Young Michael J. 
Published: October 2023

AbstractNeuroprognostication following acute brain injury (ABI) is a complex process that involves integrating vast amounts of information to predict a patient's likely trajectory of neurologic recovery. In this setting, critically evaluating salient ethical questions is imperative, and the implications often inform high-stakes conversations about the continuation, limitation, or withdrawal of life-sustaining therapy. While neuroprognostication is central to these clinical “life-or-death” decisions, the ethical underpinnings of neuroprognostication itself have been underexplored for patients with ABI. In this article, we discuss the ethical challenges of individualized neuroprognostication including parsing and communicating its inherent uncertainty to surrogate decision-makers. We also explore the population-based ethical considerations that arise in the context of heterogenous prognostication practices. Finally, we examine the emergence of artificial intelligence-aided neuroprognostication, proposing an ethical framework relevant to both modern and longstanding prognostic tools.
2.10 Iron-Catalyzed Cross Coupling of Alkyl Electrophiles
Authors: Adak L. , Sahoo S. , Aoki S. , Kawanaka Y. , Nakamura M. 
Published: October 2023

AbstractOver the past several decades, significant progress has been made in the field of transition-metal-catalyzed carbon–carbon bond formation. Among these advancements, iron-catalyzed reactions have garnered significant attention in organic chemistry due to their economic and environmental advantages. Iron complexes have emerged as highly promising catalysts for carbon–carbon coupling reactions. They possess several advantageous features, such as low cost, widespread availability, and lower toxicity compared to other transition metals commonly used as catalysts. Through the utilization of iron catalysts, the coupling of organometallic reagents with diverse substrates has been achieved, leading to the synthesis of a wide range of important organic compounds. In this review, the main focus is on iron-catalyzed cross-coupling reactions involving alkyl electrophiles and various organometallic reagents. These organometallic reagents include those based on organomagnesium, organozinc, organoaluminum, and organoboron nucleophiles. The objective is to create C—C bonds through these reactions. Iron salts, when combined with suitable additives or ligands, have been employed as efficient catalysts in these processes.
2.12 Asymmetric C—H Oxidation with Biologically Inspired Manganese and Iron Catalysts
Authors: Vicens L. , Palone A. , Costas M. 
Published: October 2023

AbstractEnantioselective oxidation of aliphatic C—H bonds is the most straightforward and atom-economical approach to prepare chiral oxygenated hydrocarbon skeletons, which are ubiquitous in molecules of biological and industrial relevance. In Nature, this reaction is carried out by metalloenzymes with high levels of efficiency and selectivity. Due to the exquisite performance of enzymatic systems, their active site has served as inspiration for the exploration of artificial catalysts, such as those based on porphyrins or coordination compounds with tetradentate salen- or bis-amine-bis-pyridine-type ligands. Reviewed herein are the latest advances in enantioselective C—H oxidations using biologically inspired iron and manganese complexes.
China’s mask and vaccine diplomacy in Latin America: a success story?
Authors: Nolte Detlef 
Published: October 2023

AbstractThe article offers a differentiated and encompassing assessment regarding China's mask and vaccine diplomacy as part of a strategy to advance its interests in Latin America. It revises the extant literature on the topic and provides a broad overview of the state of research. While most studies only cover the period until mid-2021, this article provides a comprehensive compilation of descriptive statistics on shipments and donations of COVID-19 vaccine to Latin America until the end of 2021. The data shows how Chinese advantages regarding the delivery of vaccines evaporated in the second half of 2021. While the Chinese government was relatively successful in avoiding damage to its image at the beginning of the pandemic, it failed to consolidate sympathy gains in Latin America. China has also been unable to capitalize on its mask and vaccine diplomacy to further push back Taiwan's influence in the region. Chinese mask and vaccine diplomacy was not a game changer in Latin America, neither in geopolitical nor in geo-economic terms.
Hermeneutic Calvinball versus modest digital humanities in philosophical interpretation
Authors: Alfano Mark 
Published: October 2023

AbstractIn “Calvin and Hobbes,” the character Calvin invents the game of Calvinball. No two games of Calvinball are alike because the only stable rule of Calvinball is that the players make up the rules as they go along, and no rule (other than the one stable rule) can be used twice. Whether a player is winning at a particular game of Calvinball is thus definitionally indeterminate. In philosophy, we risk playing something like Calvinball. It’s often unclear what the rules are, whether there are rules, and who gets to make up the rules as we go along. Even in the more restricted domain of the history of philosophy—the focus of the current paper—it’s often unclear what the rules are, whether there are rules, and who gets to make them up as we go along. Some interpreters of, for instance, Nietzsche, insist on sticking to the letter of the text. Others, most notoriously Heidegger and his followers, insist that what’s most important about a philosopher like Nietzsche is not what he wrote but what he didn’t write. Just like in Calvinball, because people play by different rules and make it up as they go along, it can be hard to tell who is winning an interpretive argument. This paper proposes that digital humanities offers a modest way forward for interpreters who don’t want to play Calvinball. In particular, it is argued that digital humanities methods can be used (1) to set a default for the importance of various concepts, (2) to periodize a philosopher’s works and track the increase or decline in importance of various concepts across a philosopher’s career, and (3) to establish which conceptual connections should or should not be attributed to a philosopher. The value of this approach is demonstrated with a detailed investigation of Nietzsche on the functions of shame.
The European approach to online disinformation: geopolitical and regulatory dissonance
Authors: Casero-Ripollés Andreu , Tuñón Jorge , Bouza-García Luis 
Published: October 2023

AbstractThe COVID-19 health crisis and the invasion of Ukraine have placed disinformation in the focus of European policies. Our aim is to analyze the emerging European policy on counter-disinformation practices and regulations. To do this, we examine developing European Union (EU) strategy, against different forms of fake news, from a multidisciplinary approach that combines Journalism and Geopolitics. Our methodology is based on the critical analysis of documents generated by the EU on disinformation from 2018 to 2022, including reports, communications, statements and other legislative texts. Our findings suggest that the EU’s policy against disinformation is based on two opposing logics that coexist and compete. The first is securitization, which understands this problem as a threat to democracy that legitimizes ‘exceptional decision-making’ from a hard power perspective. The second is based on the self-regulation and voluntarism of digital platforms with a clear orientation towards soft law and minimal intervention. The recent adoption of the Digital Services Act and the stronger regulation of online platforms do not replace this logic, since this legislation adopts a “co-regulatory framework”. The coexistence of these two logics generates internal contradictions and dissonance that can determine the future of European policies on this important topic and its chances of success.