bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody‐induced arthritis, overriding the effect of Hc encoding complement C5
Authors: Xu Zhongwei , Moreno‐Giró Àlex , Zhao Danxia , Krämer Alexander , Pandey Rajan Kumar , Xu Bingze , Lundström Susanna L. , Holmdahl Rikard 
Published: February 2024

AbstractLike rheumatoid arthritis (RA) in humans, collagen‐induced arthritis (CIA) in mice is associated with not only MHC class II genetic polymorphism but also, to some extent, with other loci including genes encoding Fc gamma receptors (FCGRs) and complement C5. In this study, we used a cartilage antibody‐induced arthritis (CAIA) model in which arthritis develops within a 12‐h timeframe, to determine the relative importance of FCGRs and C5 (Hc). In CAIA, inhibiting or deleting FCGR3 substantially hindered arthritis development, underscoring the crucial role of this receptor. Blocking FCGR3 also reduced the levels of FCGR4, and vice versa. When employing an IgG1 arthritogenic cocktail that exclusively interacts with FCGR2B and FCGR3, joint inflammation was promptly initiated in Fcgr2b−− mice but not in Fcgr3−− mice, suggesting that FCGR3 is sufficient for CAIA development. Regarding complement activation, Fcgr2b++.Hc** mice with C5 mutated were fully resistant to CAIA, whereas Fcgr2b−−.Hc** mice developed arthritis rapidly. We conclude that FCGR3 is essential and sufficient for CAIA development, particularly when induced by IgG1 antibodies. The human ortholog of mouse FCGR3, FCGR2A, may be associated with RA pathogenesis. FCGR2B deficiency allows for rapid arthritis progression and overrides the resistance conferred by C5 deficiency.
Controllably Modulating Oxygen Vacancies on Nonstoichiometric Nd−Ce−O Binary Oxides for Low‐temperature Oxidative Coupling of Methane
Authors: Gong Ying , Lu Chengxin , Zhong Xusheng , Xu Junwei , Ouyang Rumeng , Fang Xiuzhong , Xu Xianglan , Deng Chunhui , Wang Xiang 
Published: February 2024

AbstractHerein, we synthesised a series of nonstoichiometric Nd−Ce−O composite oxides with a fluorite or rare‐earth C‐type phase structure using the glycine combustion method for the oxidative coupling of methane (OCM) reaction. As the amount of Nd3+ increases, the oxygen vacancies in this series of composite oxides gradually increase, leading to an amount increasing in the C2‐selective oxygen species O2− generated by the oxygen vacancies. In addition, with the increase in Nd3+, the number of moderate basic sites on the catalyst surface also improves, another significant factor affecting the OCM reaction performance of the composite oxides. Nd0.9Ce0.1O1.55 possesses optimal low‐temperature OCM reaction performance, achieving 8.0 % C2 yield at 450 °C and 14.1 % C2 yield at 700 °C. This can be attributed to the nonstoichiometric rare‐earth C‐type crystalline phase structure of Nd0.9Ce0.1O1.55, which exhibits the highest abundance of oxygen vacancies, selective oxygen species O2−, and moderate basic sites.
In search of a neuropsychological profile for migraine: A scoping review
Authors: Richardson Shannon , Diaz‐Orueta Unai 
Published: February 2024

AbstractObjectiveMigraine is commonly overlooked by the general population and by professionals in research and clinical practice. Moreover, it is difficult to grasp the neuropsychological profile of migraineurs due to the cyclic nature of the disorder. With this in mind, a scoping review of the literature was conducted with the goal of characterizing cognitive domains associated with deficits in migraine.MethodsPubMed, PsychInfo, Scopus, EMBASE and OpenGrey databases were searched for studies published from 1st January 2006 to 30th November 2022. Following the review process, 52 eligible studies were included in the review.ResultsStudies included in this review show mixed and sometimes contradictory findings. Overall, both visual and auditory perception appear to be impaired. Deficits on attention, many memory processes, visuospatial function and spatial navigation and on a wide range of executive functions (set‐shifting and cognitive flexibility, decision‐making and reasoning, working memory and prospective memory) complete a complex cognitive profile in migraine. Lack of consistency across studies in sample selection and sizes, lack of detailed links between cognitive deficits and specific migraine phases, or length and chronicity, inconsistencies on the role of aura in cognitive function; and heterogeneity and sometimes questionable reliability and validity of some of the cognitive measures used may affect the clarity and consistency of results observed.ConclusionFurther research properly addressing the role of gender and age, migraine stage, length and chronicity of the condition, the effect of aura and comorbidities is needed, alongside increasing consistency across diverse neuropsychological assessment protocols.SignificanceThis review provides a comprehensive, up‐to‐date picture of the current status of knowledge in relation to the characterization of the complex cognitive profile of migraine. It offers detailed information of the existing research gaps and challenges to improve the cognitive characterization of migraine across its different stages and leads clinicians to carefully consider the selection of relevant cognitive tasks, in order to grasp more accurately the patient’s cognitive profile; an assessment that should be an integral part of any protocol developed for the clinical assessment and subsequent treatment planning for migraine.
Seven weeks of pectoralis muscle stretching does not induce non‐local effects in dorsiflexion ankle range of motion
Authors: Konrad Andreas , Reiner Marina , Manieu Josefina , Fischer Josef , Schöpflin Adrian , Tilp Markus , Behm David George 
Published: February 2024

AbstractBoth an acute bout, as well as chronic static stretching (SS), can increase the joint range of motion (ROM). However, ROM increases of a non‐stretched muscle (non‐local) are reported following an acute SS session, and these effects have not been studied for long‐term SS training. Therefore, this study aimed to investigate the effects of a comprehensive 7‐week SS training program of the pectoralis muscles on ankle dorsiflexion ROM. Thirty‐three healthy, physically active participants (20 male and 13 female) were assigned to either the SS (n = 18) or the control (n = 15) group. The SS group performed a 7‐week SS intervention that comprised three sessions a week, including three exercises of the pectoralis muscles for 5‐min each. Before and after the intervention period, the ankle dorsiflexion ROM was tested with a dynamometer. There was no significant time (p = 0.93, F1,31 = 0.008; η2 = 0.000) or time x group effect (p = 0. 56, F1,31 = 0.342; η2 = 0.011) in ankle dorsiflexion ROM, indicating no changes in ROM in the intervention as well as the control group. Although previous studies on the acute effects of stretching reported non‐local increases in ROM, our study showed no such changes after 7 weeks of SS training. Consequently, if the goal is to chronically increase the ROM of a specific joint, it is recommended to directly stretch the muscles of interest.
Forecasting GDP growth: The economic impact of COVID‐19 pandemic
Authors: Vrontos Ioannis D. , Galakis John , Panopoulou Ekaterini , Vrontos Spyridon D. 
Published: February 2024

AbstractThe primary goal of this study is to effectively measure the impact of a severe random shock, such as the COVID‐19 pandemic on aggregate economic activity in Greece, seven other euro area economies, three Scandinavian countries, and the United States. The class of linear and quantile predictive regression models is proposed for the analysis of real gross domestic product (GDP) growth, and a Bayesian approach for model selection is developed, by using a computationally flexible Markov chain Monte Carlo stochastic search algorithm that explores the posterior distribution of linear and quantile models, and identifies the relevant predictor variables. Penalized likelihood regression models are also implemented to tackle the issue of model selection. The model confidence set approach is applied and verifies that the selected models identified by the stochastic search algorithm belong to the set of superior models. Our analysis confirms that the outbreak of the pandemic had a profound effect on the economies under study, and reveals that different predictor variables are able to explain different quantiles of the underlying real GDP growth distribution for analyzed countries, suggesting that the quantile modeling approach improves the ability to adequately explain real GDP series compared with the standard conditional mean approach that explains only the average of the relationship between real GDP growth and several predictor variables.
PMP2 regulates myelin thickening and ATP production during remyelination
Authors: Hong Jiayue , Garfolo Rebekah , Kabre Sejal , Humml Christian , Velanac Viktorija , Roué Clémence , Beck Brianna , Jeanette Haley , Haslam Sarah , Bach Martin , Arora Simar , Acheta Jenica , Nave Klaus‐Armin , Schwab Markus H. , Jourd'heuil David , Poitelon Yannick , Belin Sophie 
Published: February 2024

AbstractIt is well established that axonal Neuregulin 1 type 3 (NRG1t3) regulates developmental myelin formation as well as EGR2‐dependent gene activation and lipid synthesis. However, in peripheral neuropathy disease context, elevated axonal NRG1t3 improves remyelination and myelin sheath thickness without increasing Egr2 expression or activity, and without affecting the transcriptional activity of canonical myelination genes. Surprisingly, Pmp2, encoding for a myelin fatty acid binding protein, is the only gene whose expression increases in Schwann cells following overexpression of axonal NRG1t3. Here, we demonstrate PMP2 expression is directly regulated by NRG1t3 active form, following proteolytic cleavage. Then, using a transgenic mouse model overexpressing axonal NRG1t3 (NRG1t3OE) and knocked out for PMP2, we demonstrate that PMP2 is required for NRG1t3‐mediated remyelination. We demonstrate that the sustained expression of Pmp2 in NRG1t3OE mice enhances the fatty acid uptake in sciatic nerve fibers and the mitochondrial ATP production in Schwann cells. In sum, our findings demonstrate that PMP2 is a direct downstream mediator of NRG1t3 and that the modulation of PMP2 downstream NRG1t3 activation has distinct effects on Schwann cell function during developmental myelination and remyelination.
Predicting risk of dementia among the elderly with major depressive disorder in remission: A prospective study
Authors: Lin Yen‐Ju , Huang Mei‐Feng , Yeh Yi‐Chun , Chen Cheng‐Sheng 
Published: February 2024

AbstractObjectivesCognitive impairment and change are a focus of research into late‐life depression. The aims of this 5‐year prospective study were (1) to observe cognitive status change; (2) to investigate the rate and risk ratio of dementia or cognitive decline; and (3) to examine the cognitive domain predictors for conversion to dementia within 5 years among a clinical cohort with remitted major depressive disorder (MDD).MethodsThe study cohort included 130 elderly persons with late‐life remitted MDD and 100 normal controls. Comprehensive neuropsychological tests were conducted to determine cognitive domain status. Diagnoses of mild cognitive impairment (MCI) and dementia were made at baseline and at a follow‐up visit at the 5‐year point. In total, 98 cases and 55 normal controls completed the 5‐year follow‐up assessment.ResultsOf the study cohort with late‐life remitted MDD, 28.6% had MCI and 25.5% developed dementia within 5 years. Patients with late‐life remitted MDD had an approximate 3 times higher risk of subsequent cognitive decline as compared with the normal controls. Information‐processing speed (p = 0.009) and memory (p = 0.041) could predict subsequent progression to dementia within 5 years among patients with MDD.ConclusionsThis study demonstrated that compared with the general elderly population, elderly patients with depression have more significant impairment in cognitive function after 5 years. Further, we found that in depressed patients, deficits in information‐processing speed and memory domains were highly suggestive of progression to dementia within 5 years.
Predicting repeat consumer bankruptcy: A survival analysis of business‐related repeat filings in Australia 2007–2021
Authors: Robinson Catherine , Smith David , Wicht Mark , Rice Amanda , McCosker Gavin , McBride Ignatius 
Published: February 2024

AbstractOngoing legislative responses to the impacts of the pandemic have prompted many countries to evaluate whether their bankruptcy systems remain fit for purpose. Moreover, the current climate highlights the importance of data‐driven policy, which the literature identifies as a deficiency of bankruptcy regimes. In Australia, the 2015 reform proposals to reduce the default discharge period from 3 years to 1 year are currently being revised amidst stakeholder concern about potential abuse and repeat bankrupts. Although an extensive body of literature exists on ‘repeat filers’ in the USA, there has been no equivalent study in Australia. Using our data of 153,526 bankruptcies between 2007 and 2021, we conducted a novel application of survival analysis to predict the probability of a repeat bankruptcy comparing business and non‐business groups. The results show that this probability peaked in both male and females with non‐business‐related administrations irrespective of client's age, employment and relationship status. These findings are important as they identify the prospects that certain bankrupt groups have higher rates of repeat bankruptcy, which can inform strategies to improve their survival rate. A significance of our study is the development of a high‐quality longitudinal dataset that facilitates the extension of the data models and allows easy updates about targeted questions involving bankruptcy‐related policy shifts and impacts on sub‐populations. This methodological approach will enable regulators and insolvency experts to address concerns of repeat bankruptcy to guide policy, evaluate reform and extend the evidence base in other jurisdictions.
Long‐term health‐related quality of life in head and neck cancer survivors: A large multinational study
Authors: Taylor Katherine J. , Amdal Cecilie D. , Bjordal Kristin , Astrup Guro L. , Herlofson Bente B. , Duprez Fréderic , Gama Ricardo R. , Jacinto Alexandre , Hammerlid Eva , Scricciolo Melissa , Jansen Femke , Verdonck‐de Leeuw Irma M. , Fanetti Giuseppe , Guntinas‐Lichius Orlando , Inhestern Johanna , Dragan Tatiana , Fabian Alexander , Boehm Andreas , Wöhner Ulrike , Kiyota Naomi , Krüger Maximilian , Bonomo Pierluigi , Pinto Monica , Nuyts Sandra , Silva Joaquim Castro , Stromberger Carmen , Specenier Pol , Tramacere Francesco , Bushnak Ayman , Perotti Pietro , Plath Michaela , Paderno Alberto , Stempler Noa , Kouri Maria , Grégoire Vincent , Singer Susanne ,   the EORTC Quality of Life Group and the EORTC Head and Neck Group
Published: February 2024

AbstractHead and neck cancer (HNC) patients suffer from a range of health‐related quality of life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group and HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, HNC survivors completed the European Organization for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (EORTC‐QLQ‐C30) and its HNC module (EORTC‐QLQ‐H&N35). Meaningful HRQoL differences were examined between five treatment groups: (a) surgery, (b) radiotherapy, (c) chemo‐radiotherapy, (d) radiotherapy ± chemotherapy and neck dissection and (e) any other surgery (meaning any tumour surgery that is not a neck dissection) and radiotherapy ± chemotherapy. Twenty‐six sites in 11 countries enrolled 1105 survivors. They had a median time since diagnosis of 8 years, a mean age of 66 years and 71% were male. After adjusting for age, sex, tumour site and UICC stage, there was evidence for meaningful differences (10 points or more) in HRQoL between treatment groups in seven domains (Fatigue,Mouth Pain,Swallowing,Senses,Opening Mouth,Dry MouthandSticky Saliva). Survivors who had single‐modality treatment had better or equal HRQoL in every domain compared to survivors with multimodal treatment, with the largest differences forDry MouthandSticky Saliva. ForGlobal Quality of Life,Physical and Social Functioning,Constipation,Dyspnoea and Financial Difficulties, at least some treatment groups had better outcomes compared to a general population. Our data suggest that multimodal treatment is associated with worse HRQoL in the long‐term compared to single modality.
Evidence for the Possible Relationship of Neonatal Skinfold Thickness to Maternal Glucose Metabolism During the Third Trimester
Authors: Kerner John A. , Stevenson David K. , Hattner Jo Ann , Cohen Ronald S. , Schwartz Herbert C. , Sunshine Philip 
Published: February 2024

SummaryForty‐eight infants, including 14 premature infants who were appropriate size for gestational age (AGA), 10 full‐term AGA infants, 18 full‐term infants who were large for gestational age (LGA), and six premature LGA infants of diabetic mothers (IDMs). had measurements of skinfold thickness (SFT) in the first 72 h of life. For the 24 LGA infants, there was a significant positive correlation between maternal glycohemoglobin (Hb AIc.) in the postpartum period and SFT (r = 0.42, p < 0.05). Our observations in this study support those of others, demonstrating that SFT increases with increasing gestational age. In addition, they support the hypothesis that, in diabetic pregnancies, or pregnancies associated with an elevated Hb AIc, a reflection of the time‐integrated blood glucose level over the weeks preceding parturition, fetal hyperglycemia and hyperinsulinemia stimulate increased triglyceride synthesis in adipose cells and lead to an increase in fetal subcutaneous fat.
Comparison of Acquired Monosaccharide Intolerance and Acute Diarrheal Syndrome
Authors: Jalili Firooz , Smith E. O'Brian , Nichols Veda N. , Mintz A. Aaron , Nichols Buford L. 
Published: February 2024

SummaryIn a retrospective study. 9% of the admissions to Ben Taub General Hospital for diarrhea were found to have acquired monosaccharide intolerance (AMI). The course of AMI was compared with that of acute diarrheal syndrome (ADS). The patients with AMI were younger at the time of admission, and, although the mean birthweight and percent of prematurity were approximately the same in the two groups, the AMI patients were found to be malnourished (p < 0.02). Data suggest that the nutritional insult had occurred between birth and admission, and that malnutrition was a contributing factor in the development of AMI.
Rapid Changes of Serum Vasoactive Intestinal Peptide After Removal of Ganglioneuroblastoma with Watery‐Diarrhea‐ Hypokalemia‐ Achlorhydria Syndrome in a Child
Authors: Funato Masahisa , Fujimura Masanori , Shimada Seiichi , Takeuchi Toru , Kozuki Kiyoshi , Iida Yoshihiko 
Published: February 2024

SummaryA 23‐month‐old girl with intractable diarrhea that had persisted for the past 6 months showed typical evidence of wa‐ter‐diarrhea‐hypokalemia‐achlorhydria (WDHA) syndrome. Serum vasoactive intestinal peptide (VlP)‐like immunoactivity was very high, and urine homovanillic acid and noradrenaline were also abnormally increased. A calcified tumor in the right paravertebral region was noted radiologically. Soon after resection of the tumor, the diarrhea dramatically improved. A ganglioneuroblastoma was histologically confirmed. Serum VIP decreased to normal level at 1 h after the removal of the tumor. VIP activity in the tumor was extraordinarily high, and the cells were stained by the indirect immunofluorescence technique with anti‐VIP serum. This is to report the rapid turnover of serum level of VIP after resection of ganglioneuroblasoma with WDHA syndrome in a child.
The Physiologic and Pathologic Basis for the Transport of Macromolecules Across the Intestinal Tract
Authors: Udall J. N. , Walker W. A. 
Published: February 2024

SummaryTransport of intact macromolecules across the intestine probably occurs in all mammalian species. It appears to be greatest early in life. The degree to which it occurs may be related to normalcy of gastric, pancreatic, and small intestinal function.
Results of Feeding a Special Formula to Very Low Birth Weight Infants
Authors: Curran John S. , Barness Lewis A. , Brown David R. , Holzman Ian R. , Rathi Manohar L. , Silverio John , Tomarelli Rudolph 
Published: February 2024

SummaryFifty‐eight premature infants weighing less than 1.600 g at birth were fed a special formula. The formula contained nutrients in amounts recommended by the Committee on Nutrition of the American Academy of Pediatrics for very low birth weight (VLBW) infants. The feeding studies were carried out at newborn nurseries in Tampa. Florida (study A. n = 25). Pittsburgh, Pennsylvania (study B, n = 20). and Oaklawn. Illinois (study C. n = 13). Study subjects were comparable in birth weight, gestational age, and in the duration of follow‐up in the nurseries. All study subjects grew at rates of weight acquisition equivalent to the comparative fetal counterpart. Routine anthropometric measurements were similar to those of fetal development curves. Mean protein intake ranged from 2.3 to 3.7 g/kg/day and mean caloric intake from 105 to 150 kcal/kg/day. Late metabolic acidosis in association with prematurity was absent in all subjects studied as demonstrated by normal pH values, bicarbonate, and partial pressure of carbon dioxide. Serum sodium and serum chloride levels were normal. Serum calcium ranged from 8.3 to 10.1 mg/dl and serum phosphorus from 6.0 to 7.5 mg/dl. Total serum protein levels ranged from 4.5 to 5.1 g/dl. Blood urea nitrogen diminished progressively from 5.1 to 2 mg/dl in the course of the study. Serum glucose levels in samples taken prior to and 2 h after feeding did not demonstrate any evidence of reactive hypoglycemia.
Chick Embryo Intestine in Culture
Authors: Moog Florence , Goellner Joseph J. 
Published: February 2024

SummaryThe development of alkaline phosphatase, maltase, and sucrase activities in the duodenum of the chick embryo was followed in organ culture in chemically defined medium; 14‐day duodenum was used in most experiments, with comparisons being made with 18‐day tissue. As has been previously shown for the other enzymes, sucrase activity also rises at an accelerated rate in vitro. Since chick sucrase has maltase activity, its increase appears to account for the spontaneous rise of maltase activity; the form of maltase devoid of sucrase activity seems not to be accelerated. Sucrase, sucrase‐free maltase, and alkaline phosphatase are all elevated by the addition of insulin to the medium. Intestinal sucrase is well known to be responsive to hydrocortisone, but it has now been found to be unresponsive to thyroxine, except that its dissociation from the brush border is increased at hormone concentrations above 1 nM. Insulin and thyroxine act synergistically on alkaline phosphatase, but the addition of hydrocortisone diminishes the effect of the other two. With sucrase, insulin and hydrocortisone have a synergistic effect which is intensified by addition of thyroxine. The previously demonstrated influence of hydrocortisone on maltase is accounted for by the maltase activity of sucrase. In combination, however, hydrocortisone and thyroxine elevate maltase much more strongly than sucrase, and the highest maltase levels were attained when all three hormones were present.