bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network federation: Challenges and opportunities
Authors: Santos David , Corujo Daniel , Quevedo José , Aguiar Rui 
Published: October 2023

AbstractNetwork federation is a promising approach for organizations to improve their infrastructure by pooling their resources and creating a larger, more scalable network. Despite the many benefits of network federation, there are also significant challenges that must be addressed, such as security, interoperability, and policy management. Various efforts have been underway for many years to develop common standards and protocols, to overcome these challenges. This paper provides a comprehensive overview of the challenges and opportunities of network federation, and presents the standardization efforts in the field.
miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response
Authors: Biswal Priyajit , Lalruatfela Anthony , Behera Subham Kumar , Biswal Sruti , Mallick Bibekanand 
Published: October 2023

AbstractMicroRNAs (miRNAs) are a class of noncoding RNAs of about 19–25 nucleotides, which serve as critical modulators of various cellular and biological processes by target gene regulation. Dysregulated expression of miRNAs modulates the pathophysiology of various human diseases, including cancer. Among miRNAs, miR‐203a is one of the most extensively researched dysregulated miRNAs in different cancers. Our review investigated the roles of miR‐203a in the hallmarks of cancer modulating different pathways through target gene regulations, chemoresistance, its crosstalk with other ncRNAs or genes in terms of ceRNAs impacting oncogenesis, and its potential applications in the diagnosis, prognosis, and chemotherapeutic responses in different cancer types. miR‐203a impacts cancer cell behavior by regulating these exclusive hallmarks‐ sustaining proliferation, cell growth, invasion and metastasis, cell death, and angiogenesis. Besides, miR‐203a is found in human circulating biofluids like plasma or serum of colorectal cancer, cervical cancer, and hepatocellular carcinoma, hinting at its potential as a biomarker. Further, miR‐203a is involved in enhancing the chemosensitivity of cisplatin, docetaxel, paclitaxel, doxorubicin, and 5‐fluorouracil in a variety of malignancies through their cognate target genes. These results suggest that miR‐203a is a crucial multifaceted miRNA that controls cancer cell proliferation, metastasis, and chemotherapy response, shedding new light on its possible application.
Is Higher Docetaxel Clearance in Prostate Cancer Patients Explained by Higher CYP3A? An In Vivo Phenotyping Study with Midazolam
Authors: van der Heijden Lisa T. , Ribbers Claire A. , Vermunt Marit A.C. , Pluim Dick , Acda Manon , Tibben Matthijs , Rosing Hilde , Douma Joeri A.J. , Naipal Kishan , Bergman Andre M. , Beijnen Jos H. , Huitema Alwin D.R. , Opdam Frans L. 
Published: October 2023

AbstractPatients with prostate cancer (PCa) have a lower docetaxel exposure for both intravenous (1.8‐fold) and oral administration (2.4‐fold) than patients with other solid cancers, which could influence efficacy and toxicity. An altered metabolism by cytochrome P450 3A (CYP3A) due to castration status might explain the observed difference in docetaxel pharmacokinetics. In this in vivo phenotyping, pharmacokinetic study, CYP3A activity defined by midazolam clearance (CL) was compared between patients with PCa and male patients with other solid tumors. All patients with solid tumors who did not use CYP3A‐modulating drugs were eligible for participation. Patients received 2 mg midazolam orally and 1 mg midazolam intravenously on 2 consecutive days. Plasma concentrations were measured with a validated liquid chromatography–tandem mass spectrometry method. Genotyping was performed for CYP3A4 and CYP3A5. Nine patients were included in each group. Oral midazolam CL was 1.26‐fold higher in patients with PCa compared to patients with other solid tumors (geometric mean [coefficient of variation], 94.1 [33.5%] L/h vs 74.4 [39.1%] L/h, respectively; P = .08). Intravenous midazolam CL did not significantly differ between the 2 groups (P = .93). Moreover, the metabolic ratio of midazolam to 1′‐hydroxy midazolam did not differ between the 2 groups for both oral administration (P = .67) and intravenous administration (P = .26). CYP3A4 and CYP3A5 genotypes did not influence midazolam pharmacokinetics. The observed difference in docetaxel pharmacokinetics between both patient groups therefore appears to be explained neither by a difference in midazolam CL nor by a difference in metabolic conversion rate of midazolam.
Use of design thinking and human factors approach to improve situation awareness in the pediatric intensive care unit
Authors: Gifford Annika , Butcher Bain , Chima Ranjit S. , Moore Lindsey , Brady Patrick W. , Zackoff Matthew W. , Dewan Maya 
Published: October 2023

AbstractBackgroundOptimal design of healthcare spaces can enhance patient care. We applied design thinking and human factors principles to optimize communication and signage on high risk patients to improve situation awareness in a new clinical space for the pediatric ICU.ObjectiveTo assess the impact of these tools in mitigating situation awareness concerns within the new clinical space. We hypothesized that implementing these design‐informed tools would either maintain or improve situation awareness.Design, Settings, and ParticipantsA 15‐week design thinking process was employed, involving research, ideation, and refinement to develop and implement new situation awareness tools. The process included engagement with interprofessional clinical teams, scenario planning, workflow mapping, iterative feedback collection, and collaboration with an industry partner for signage development and implementation.InterventionImproved and updated communication devices and bedside mitigation plans.Main Outcome and MeasuresProcess metrics included individual and shared situation awareness of PICU care teams and our patient outcome metric was the rate of cardiopulmonary resuscitation (CPR) events pre‐ and post‐transition.ResultsWhen evaluating all patients, shared situation awareness for accurate high‐risk status improved from 81% pre‐transition to 92% post‐transition (p = .006). When assessing individual care team roles, accuracy of patient high‐risk status improved from 88% to 95% (p = .05) for RNs, 85% to 96% (p = .003) for residents, and 88% to 95% (p = .03) for RTs. There was no change in the rate of CPR events following the transition.
Spatial patterns and temporal dynamics of drought in southern Ethiopia from 1981 to 2100
Authors: Mena Markato Markos , Kenea Tadesse Tujuba , Yate Tewodros Addisu 
Published: October 2023

AbstractWe assess the spatiotemporal characteristics of historical and projected future drought over southern Ethiopia using the Standardized Precipitation Evapotranspiration Index and the K‐means clustering method. Historical assessment is done for the period 1981–2018 while projected drought is analysed over two consecutive future periods, that is, 2021–2060 (near future) and 2061–2100 (far future). Projected drought events are identified under RCP 4.5 and 8.5 climate scenarios based on three RCMs selected after performance evaluation. Modified Mann–Kendall trend test is applied to determine trends and significance at the 5% significance level. The results reveal broadly diverse and heterogeneous spatiotemporal characteristics both over the historical and future periods. Droughts of various frequencies, durations, and magnitudes are observed amongst stations, while trends generally lack spatial coherence. The year 1984 is noted to be the driest year in the historical period while the years 1982, 2009, and 1991 are with the driest March–May (MAM), June–August (JJA), and September–November (SON) seasons, respectively. Compared to the historical period, the frequency, magnitude, and duration of drought events are projected to decrease in the near future and increase in the far future. The frequency of drought events in SON and JJA seasons are projected to increase in the near future and far future, respectively, under both scenarios. More number of station shows a wetting tendency in the historical period while more number of stations exhibit a drying tendency during the projected future periods under the two scenarios. Since complex drought characteristics are observed both in the historical and future periods, rigorous local‐scale drought monitoring and management is recommended.
Characterizing the T Cell Repertoire in the Proximal Airway in Health and Disease
Authors: Clark Evan A. , Talatala Edward Ryan R. , Ye Wenda , Davis Ruth J. , Collins Samuel L. , Hillel Alexander T. , Ramirez‐Solano Marisol , Sheng Quanhu , Wanjalla Celestine N. , Mallal Simon A. , Gelbard Alexander 
Published: October 2023

ObjectivesRecent translational scientific efforts in subglottic stenosis (SGS) support a disease model where epithelial alterations facilitate microbiome displacement, dysregulated immune activation, and localized fibrosis. Given the observed immune cell infiltrate in SGS, we sought to test the hypothesis that SGS cases possessed a low diversity (highly clonal) adaptive immune response when compared with healthy controls.MethodsSingle cell RNA sequencing (scRNA‐seq) of subglottic mucosal scar in iSGS (n = 24), iLTS (n = 8), and healthy controls (n = 7) was performed. T cell receptor (TCR) sequences were extracted, analyzed, and used to construct repertoire structure, compare diversity, interrogate overlap, and define antigenic targets using the Immunarch bioinformatics pipeline.ResultsThe proximal airway mucosa in health and disease are equally diverse via Hill framework quantitation (iSGS vs. iLTS vs. Control, p > 0.05). Repertoires do not significantly overlap between individuals (Morisita <0.02). Among iSGS patients, clonality of the TCR repertoire is driven by CD8+ T cells, and iSGS patients possess numerous TCRs targeting viral and intercellular pathogens. High frequency clonotypes do not map to known targets in public datasets.ConclusionSGS cases do not possess a lower diversity adaptive immune infiltrate when compared with healthy controls. Interestingly, the TCR repertoire in both health and disease contains a restricted number of high frequency clonotypes that do not significantly overlap between individuals. The target of the high frequency clonotypes in health and disease remain unresolved.Level of EvidenceNA Laryngoscope, 134:1757–1764, 2024
Nitric Oxide‐Releasing Macromolecular Systems in Anticoagulant Therapeutics
Authors: Luo Siyuan , Sheng Jiahui , Jia Xiaoyu , Zhang Guoying , Wang Xiaotian , Hu Jinming 
Published: October 2023

AbstractNitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are considered endogenous gaseous signaling molecules that play crucial roles in regulating physiological and pathological pathways. Among these molecules, NO has demonstrated unique advantages and clear efficacy in the treatment of blood coagulation in cardiovascular diseases. As a result, the development of NO‐releasing materials for anticoagulant therapeutics has garnered significant attention. However, unlike traditional anticoagulant treatments such as heparin and oral anticoagulants, NO, a gaseous molecule under ambient conditions, cannot be administered orally, through injection, or via the skin. Consequently, researchers have focused on developing NO‐releasing macromolecular systems by combining various donors with polymeric materials for use in anticoagulant therapeutics. This minireview aims to highlight the methods and advancements in constructing such NO‐releasing macromolecular systems and exploring their applications in anticoagulant therapeutics.
The initial assessment of an important pelagic fish, Mackerel Scad, in the South China Sea using data-poor length-based methods
Authors: Xu Youwei , Zhang Peng , Panhwar Sher Khan , Li Jie , Yan Lei , Chen Zuozhi , Zhang Kui 
Published: October 2023

Abstract

Objective
Scads Decapterus spp. occur widely throughout tropical, subtropical, and temperate oceans and are both economically and ecologically important species. They are among the main commercial fish species caught by the light falling-net fishery in the South China Sea, which is dominated by Mackerel Scad Decapterus macarellus and Shortfin Scad D. macrosoma. Stock assessment is an approach used to guide effective management and maintain fishery sustainability.

Methods
Two data-poor methods, namely length-based Bayesian biomass estimation and length-based spawning potential ratio, were applied to assess the status of Mackerel Scad, the most dominant Decapterus species in the South China Sea. Electronic length–frequency analysis was used to estimate von Bertalanffy growth parameters (asymptotic length Linf and growth coefficient K) to serve as priors.

Result
The results show the estimated Linf and K of Mackerel Scad in the South China Sea as 36.0 cm and 0.37/year, respectively. Estimated natural mortality was 0.74/year, and mean fork length at 50% sexual maturity was 24.29 cm. Length-based Bayesian biomass estimation analysis showed that the estimated relative stock size had decreased from 1.3 in 2012–2014 to 0.7 in 2019–2021, indicating an overfished status. Length-based spawning potential ratio analysis showed that the estimated spawning potential ratio for this fishery decreased from 13% to 12%, which is significantly below the limit reference point of 20%.

Conclusion
Our results obtained through length-based methods indicate the lower SPR of Mackerel Scad stock was due to catching an excess of juveniles. Therefore, we highlight the need to increase the minimum mesh size in the fishing nets and strengthen international cooperation for conserving this shared stock in the South China Sea.
Pulsed wave Doppler ultrasound: Accuracy, variability, and impact of acquisition parameters on flow measurements
Authors: Russ Megan K. , Lafata Nicole M. , Robertson Scott H. , Samei Ehsan 
Published: October 2023

AbstractBackgroundPulsed wave Doppler ultrasound is a useful modality for assessing vascular health as it quantifies blood flow characteristics. To facilitate accurate diagnosis, accuracy and consistency of this modality should be assessed through Doppler quality assurance (QA).PurposeThe purpose of this study was to characterize the accuracy, reproducibility, and inter‐scanner variability of ultrasound flow velocity measurements via a flow phantom, with a focus on the effect of systematic acquisition parameters on measured flow velocity accuracy.MethodsUsing a manufacturer‐calibrated flow phantom, pulsed wave measurements were acquired on five clinical systems (iU22, Philips) with three models of transducers, including both linear and curvilinear models. The peak and mean flow velocities were estimated by vendor‐supplied spectral analysis tools. To investigate intra‐ and inter‐scanner variability, measurements were repeated using each scanner‐transducer pair under a standardized set of conditions. Inter‐scanner variability was assessed using ANOVA. Flow velocity accuracy was investigated by mean absolute percentage error. The impacts of receive gain, measurement depth, and beam steering on measured flow velocity accuracy were examined by varying each parameter over its available range and comparing to the ground truth flow velocity.ResultsInter‐scanner variability was statistically significant for peak flow measurements made using both linear and curvilinear transducers, though absolute differences in measured velocity were small. Inter‐scanner variability was not statistically significant for mean flow velocity. Receive gain, measurement depth, and beam steering were all found to impact the accuracy of measured flow characteristics for linear transducers. Accuracy of the flow measurements made with the curvilinear transducer demonstrated high consistency to changes in receive gain at a constant depth, though were impacted by increasing the measurement depth.ConclusionsCarefully and consistently selected acquisition and set‐up parameters are essential in order to establish a reliable and meaningful QA program.
Impacts of gray market selling on the supply chain under product upgrade and pricing flexibility decisions
Authors: Srivastava Abhishek , Choi Tsan‐Ming , Mahajan Aarushi , Roy Vivek 
Published: October 2023

AbstractGray markets are infamous for unauthorized diversion of authentic products at lower prices to harm the manufacturer's authorized distribution channel. Hence, manufacturers are becoming more proactive in shaping strategies that can counter gray markets. By considering the risk of unauthorized selling through gray markets, we analyze the manufacturer's strategic channel choice and product upgrade decision. We analytically explore the provision of granting flexibility to the legitimate retailer to adjust price during the selling season as a strategy to cope with gray market. We find that unauthorized selling through gray markets has a severe negative impact on the manufacturer's profitability depending on the degree of channel differentiation and product brand equity. We counter‐intuitively reveal that the overall decentralized supply chain can be better‐off, owing to higher product leakage, especially because the legitimate retailer gains an increased sales volume through product diversion to the gray market. However, the manufacturer's loss is more severe in such a decentralized supply chain. We show that the manufacturer can eliminate unauthorized sales through gray market by offering price adjustment flexibility to the retailer. Another compelling finding exhibits that the manufacturer's decision to launch an upgraded product can intensify the diversion of an existing product. However, unfair competition from the unauthorized channel cannibalizes the sales of an upgraded product, thereby making the manufacturer worse‐off. Interestingly, despite the cannibalization of upgraded product sales, the manufacturer can be better‐off in terms of overall profitability via price adjustment flexibility if both the degree of upgrade and brand equity are higher. Overall, in addition to deploying monitoring mechanisms for supervising legitimate retailers, price adjustment flexibility can reduce product diversion if the degree of upgrade is moderate and channel differentiation is higher.
Stronger together: Building nonprofit resilience through a network with a shared Mission and organizational humility
Authors: Woznyj Haley M. , Stewart Oscar J. , Beck Tammy E. 
Published: October 2023

AbstractNonprofit organizations increasingly face surprising and disruptive shocks, beyond financial setbacks, that challenge an organization's operations, long‐term survival, and success. To continue to execute their  mission, nonprofits must be resilient. Despite the importance of resilience in nonprofits, more research is needed to understand the factors that build organizational resilience and how leaders can help promote resilience. We conducted a qualitative case study, consisting of 23 interviews with organizational members and key partners, fieldwork, and archival information, of a documented resilient nonprofit organization. Our findings suggest that leaders can enhance resilience by gaining access to resources through collaboration, which is in line with previous theorizing. Our results add to previous research by providing a more nuanced understanding of how collaboration can facilitate resilience. Specifically, our findings suggest that resilience may be enhanced when organizational humility drives leaders to strategically constrain their network primarily to partners that share a common mission. Our research contributes predominantly to the organizational resilience literature, while offering more auxiliary contributions to the organizational humility literature. Further, our research offers practical guidance for how leaders of nonprofits can develop resilience in their organizations.
Massively parallelizable proximal algorithms for large‐scale stochastic optimal control problems
Authors: Sampathirao Ajay K. , Patrinos Panagiotis , Bemporad Alberto , Sopasakis Pantelis 
Published: October 2023

AbstractScenario‐based stochastic optimal control problems suffer from the curse of dimensionality as they can easily grow to six and seven figure sizes. First‐order methods are suitable as they can deal with such large‐scale problems, but may perform poorly and fail to converge within a reasonable number of iterations. To achieve a fast rate of convergence and high solution speeds, in this article, we propose the use of two proximal quasi‐Newtonian limited‐memory algorithms—minfbe applied to the dual problem and the Newton‐type alternating minimization algorithm (nama)—which can be massively parallelized on lockstep hardware such as graphics processing units. In particular, we use minfbe and nama to solve scenario‐based stochastic optimal control problems with affine dynamics, convex quadratic cost functions (with the stage cost functions being strongly convex in the control variable) and joint state‐input convex constraints. We demonstrate the performance of these methods, in terms of convergence speed and parallelizability, on large‐scale problems involving millions of variables.
Covalent functionalization of activated MoS2 via using alkyl sulfide and their utilization in polymeric composites with mechanical and thermal property enhancements
Authors: Li Yunxia , Song Yiming , Yang Dongchun , Tian Sheng , Deng Qin , Chen Xuegang , Wang Zhaobo , Wang Xin , Hu Haiqing , Wang Yilong , Tao Yong , Zhao Jian 
Published: October 2023

AbstractRecently developed covalent functionalization of chemically exfoliated MoS2 (typically in alkyl lithium) allows the formation of chalcogenide‐carbon bonds by reacting with organohalides and aryl diazonium salts. We herein develop a novel method for the covalent functionalization of MoS2 to yield dodecylated MoS2 via reductive activation in a strongly reducing sodium‐naphthalene solution and using alkyl sulfide as an electrophile. Dodecylated MoS2/polystyrene (PS) composites fabricated by solution casting method. Dodecyl chains are grafted successfully onto MoS2 nanosheets, which gives rise to the exfoliation level of few‐layer thickness and matched compatibility with the host polymeric matrix. The inclusion of dodecylated MoS2 at a concentration of 1.0 wt% yields a substantial improvement in both Young's modulus and tensile strength, with a 106.7% increase and a 67% enhancement, respectively, as compared to the performance of pure PS. The enhanced mechanical characteristics can be credited to the uniform dispersion of dodecylated MoS2 within the PS matrix and enhanced interfacial interaction between the PS material and the filler. The composites demonstrate a significant increase in their glass transition temperature (Tg). Notably, the dodecylated MoS2/PS (1.0 wt%) composite exhibits a 59.8% elevation in storage modulus when compared to pure PS. The coke yield of dodecylated MoS2/PS (1.0 wt%) reaches 2.7%, much larger than the value (only 0.2%) for pure PS. The novel functionalization might expedite the applications of molybdenum disulfide in diverse fields.Highlights
A novel method for the covalent functionalization of MoS2.
Dodecylated MoS2/PS composites were fabricated via solution casting method.
Ultrathin structure of MoS2 nanosheets was obtained after functionalization.
Composites improvement in Young's modulus and tensile strength compared to PS.
The composites show significant enhancements in Tg.