bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review
Authors: David Adi , Lev-Ari Shaked 
Published: January 2024

The following narrative review embarks on a comprehensive exploration of the pivotal role played by the gut microbiome within the Diet-Microbiota-Immunity (DMI) tripartite, aiming to enhance anti-cancer immunotherapy efficacy.
While revolutionizing cancer treatment, resistance to immunotherapy and immune-related adverse events (irAEs) remain challenges. The tumor microenvironment (TME), shaped by cancer cells, influences immunotherapy resistance. The gut microbiome, influenced by genetics, environment, diet, and interventions, emerges as a critical player in TME reshaping, thereby modulating immune responses and treatment outcomes. Dietary patterns like the Mediterranean diet, caloric restriction modifications, and specific nutritional components show promise in influencing the tumor microenvironment and gut microbiome for better treatment outcomes. Antibiotics, disrupting gut microbiota diversity, may compromise immunotherapy efficacy.
This review emphasizes the need for tailored nutritional strategies to manipulate microbial communities, enhance immune regulation, and improve immunotherapy accessibility while minimizing side effects. Ongoing studies investigate the impact of dietary interventions on cancer immunotherapy, pointing towards promising developments in personalized cancer care. This narrative review synthesizes existing knowledge and charts a course for future investigations, presenting a holistic perspective on the dynamic interplay between dietary interventions, the gut microbiome, and cancer immunotherapy within the DMI tripartite.
NOTA DOS EDITORES
Authors: Costa Silva Ricardo Gilson da , Vidal da Silva Viviane , Oliveira Neto Thiago 
Published: January 2024

Esperamos que o conjunto dos textos possa contribuir com o conhecimento e reflexões sobre a Amazônia em suas múltiplas territorialidades. Os textos desse dossiê correspondem em um desdobramento de reflexões realizado no “Simpósio Territorialidades Amazônicas”, com temáticas que nos ajudam a compreender a complexidade da Amazônia, região em que muitos nasceram, escolheram, sendo acolhidos para viver.
Boa leitura!
A genetic algorithm - based vehicle routing for transportation cost optimization with time-capacity-penalty constraints
Authors: Nguyen Trung-Tuan , Vu Thi-Huong-Giang , Huynh Quyet-Thang , Pham Minh-Hoan , Tong Thi-Minh-Ngoc 
Published: January 2024

Abstract
Optimizing transportation costs regarding many constraints on depots, customers, vehicles, and time windows is an urgent need of logistic businesses to get the highest profit and customer satisfaction. In this paper, we propose a genetic algorithm for optimizing the transportation cost in vehicle routing problem, comprising the penalty cost while constraints are violated. The considered constraints are: goods must be picked up from or delivered to different depots or customers at their requested time windows; vehicles are subject to a capacity limit, an operation time limit, a distance limit, and a type of goods limit.
Three experiment scenarios with real-world locations on Google maps were conducted, showing significant results on transportation costs in terms of traveled distance and number of used vehicles. The experimental results, compared to other methods, show the effectiveness and practical applicability of the proposed algorithm.
Size-Dependent Effects of Silver Nanoparticles in Colorectal Cancer Treatment: Apoptosis Activation, Anti-Metastatic Properties, and Tissue Accumulation
Authors: Karakurt Serdar , BILGISEVEN Irem Mukaddes , CINAR Sumeyya , BILECEN Deniz SEZLEV , KANDIR Sinan 
Published: January 2024

Abstract
Nanoparticles possess unique characteristics due to their small size and high surface area-to-volume ratios, enabling facile interactions with biomolecules, cells, and tissues upon entry into the body. This study investigates the size-related effects of silver nanoparticles (AgNPs) in the context of colorectal cancer treatment. The proposed mechanism, resembling “Trojan horses”, elucidates the toxicity of AgNPs; AgNPs transport metallic silver across cell membranes and then dissolve intracellularly to release Ag2+ ions. To explore the impact of AgNP size, a range of AgNPs with varying sizes was synthesized. The cytotoxic effects of synthesized AgNPs (5 nm, 10 nm, 40 nm, and 100 nm) in colorectal cancer cell lines; CaCo-2, SW-620, DLD-1, HT-29, and healthy colon epithelial cell line CCD-18Co were determined in vitro. The distribution and amount of different-sized AgNPs in rat tissues at 24-hour and 48-hour post-administration were determined by ICP-MS method. Experimental findings revealed that the apoptotic pathway in DLD-1 and HT-29 cells was activated by AgNPs, and this activation exhibited a positive correlation with increasing AgNP size. Furthermore, an increase in size was associated with decreased metastatic properties, resulting in a reduced ability to form colonies. AgNP therapy induced the activation of proteins and genes involved in various pathways, including TGFβ, WNT, MAPK, PI3K-Akt, and p53. In vivo studies demonstrated the effective penetration of AgNPs into the circulatory system following intraperitoneal (IP) administration. These nanoparticles were found to accumulate extensively in the lungs, liver, heart, kidneys, and colon. 5 nm AgNPs were rapidly cleared from the kidney at 48 h, while 40 nm AgNPs exhibited the highest concentration in the lung at 24 h. Notably, different-sized AgNP nanoparticles exhibited distinct accumulation sites, suggesting a potential passive targeting approach for specific tissues. In conclusion, this study highlights the size-dependent effects of AgNPs in colorectal cancer treatment. The findings underscore the ability of AgNPs to activate apoptosis and modulate metastatic properties in colorectal cancer cells, with larger AgNPs exhibiting more pronounced effects. Moreover, the differential accumulation of AgNPs in various tissues offers a promising alternative strategy for passive targeting based on nanoparticle size. These insights contribute to the development of targeted therapies utilizing AgNPs in the field of cancer treatment.
Irradiated red blood cell transfusion is associated with an increased risk of deep vein thrombosis in trauma patients: a case control study
Authors: Lu Hua , Wu Li-Fang , Li Jing-Jing , Gao Qi , Xu Gui-Ping 
Published: January 2024

Abstract
Background Gamma ray irradiation accelerates the release of red blood cell (RBC)-derived microparticles with procoagulant function, and further promotes the formation of microthrombosis. The use of irradiated RBCs in nontransplant patients is usually not prohibited, except in patients with renal dysfunction and hyperkalemia. At present, the possibility that irradiated RBC transfusion promotes the occurrence of deep vein thrombosis (DVT) remains unclear.
Methods This retrospective cohort study was conducted on 251 trauma patients enrolled between January 2021 and April 2023 at the Second Affiliated Hospital of Chongqing Medical University. The cohort included 147 patients who were only transfused with nonirradiated RBCs (nonirradiation group) and 104 patients who were transfused with irradiated RBCs with or without nonirradiated RBCs (irradiation group). Multivariate logistic regression was used to analyze the risk factors for DVT in this population.
Results The incidence of DVT was higher in the irradiation group than in the nonirradiation group (38.5% vs 22.4%, P<0.01). After adjusting for inconsistent variables, the results showed that irradiated RBC transfusion was a significant risk factor for DVT (odds ratio =2.16, 95% confidence interval=1.24 to 3.76; P<0.01). The incidence of DVT increased from 22.4% to 43.8% with the rising percentage of irradiated RBCs in total transfused RBCs (P =0.0248). The median storage days and total units of irradiated RBCs were not associated with an increased risk of DVT (odds ratio <1, P>0.05). Further subgroup analysis showed that the total volume, median storage days, and maximum storage days of transfused RBCs were not associated with the occurrence of DVT in this cohort, regardless of whether the irradiation group was included (all, P>0.05).
Conclusions Irradiated RBC transfusion was associated with an increased risk of DVT in trauma patients in a percentage-dependent manner, and the total volume and longer storage duration of transfused RBCs were not associated with the incidence of DVT. The transfusion indications for irradiated RBCs should be strictly controlled to avoid unnecessary transfusion of irradiated RBCs to trauma patients.
WITHDRAWN: Linking Manufacturing Firms with Environment: Role of Green Manufacturing and Environmental Management on Firm's Environmental Performance with Moderating Effect of External Environmental Regulations
Authors: Nazir Samera , Mehmood Saqib , Nazir Zarish , Zhaolei Li 
Published: January 2024

Abstract
Purpose: The relationship between manufacturing firms and the environment became critical in contemporary business research and sustainability efforts. This study explored the complex interconnections and relationships among various factors, specifically focusing on manufacturing firms. It sought to understand how these firms' environmental performance was influenced by a combination of environmental management practices they adopted and the regulatory environment they operated in.
Design: Data were collected through a structured questionnaire from employees working in manufacturing firms in Pakistan. Random sampling was used to select the participants. The hypotheses were tested using partial least squares (PLS) analysis.
Findings: The findings of this study had significant implications for both manufacturing firms and policymakers. They provided insights into the strategies that manufacturing companies could adopt to enhance their environmental performance through green manufacturing practices and proactive environmental management. Furthermore, the research shed light on the role of external environmental regulations in moderating these processes.
Practical Implications: The practical implications offered valuable insights and guidance for manufacturing companies seeking to improve their environmental responsibility and performance. Additionally, policymakers gained insights into how regulatory frameworks could be designed or modified to better support sustainability efforts within the manufacturing sector.
Originality or Value: It emphasized the novelty and significance of the research in offering a comprehensive understanding of how manufacturing firms could navigate the complex landscape of environmental responsibility, compliance with regulations, and the simultaneous enhancement of their environmental performance. In essence, it underscored the study's role in advancing knowledge and practices related to sustainability in manufacturing.
Can green finance improve eco-efficiency? New Insights from China
Authors: Lee Chien-Chiang , Du Lixia 
Published: January 2024

Abstract

Achieving economic development and ecological protection simultaneously is an inevitable selection for sustainable development in today's world, so it is crucial to improve eco-efficiency (EE). According to Chinese panel data at the provincial level between 2010 and 2020, this research explores the nexus between green finance (GF) and EE. The results denote that GF can significantly improve EE, and the higher the level of EE, the stronger the effect of improvement. The upgrading of industrial structure, optimization of energy structure, enterprises' concern for environmental protection and the public's attention to the environment are all favorable factors that can enhance the promotion effect of GF on EE. Additionally, this facilitation can only be played under a good external environment and mature internal conditions. Our findings can provide new insights for improving EE by developing GF.
Single-cell multiomics analysis reveals SARS-CoV-2 inactivated vaccine-induced trained immunity modulated by epigenetic remodeling
Authors: Zhang Zijie , Wang Rong , Hu Huajie , Zhou Taicheng , Zhou Wei , Jiang Xinyu , Yan Shushu , Shi Tianpei , Qin Wanting , Li Xiaolu , He Yuqi , Wang Guodong , He Zhenli , Li Chunmei , Chen Yanli , Huang Dingli 
Published: January 2024

Abstract
Recent studies have revealed gene-expression signatures in response to vaccination; however, the epigenetic regulatory mechanisms that are underlying vaccine-induced immune responses remains to be elucidated. Here, we analyzed a multiomics single-nucleus data of 267,485 nuclei at 10 timepoints after SARS-CoV-2 inactivated vaccination, which showed critical time points on gene changes in each celltype. We identified some epigenetically distinct monocyte subtypes, which were characterized by persistent chromatin remodeling at AP-1-targeted binding sites after the second dose, which were only transiently activated after the first dose. This remolded chromatin correspond to changes in cytokine and interferon pathways overtime. We found a coordinated regulation of IL1B, CXCL8, CCL3 and CSF2RA by c-Fos, c-Jun, IRF family and RUNX in myeloid cells. Pseudotime analysis revealed that CD14+ monocytes tend to differentiate towards a highly inflammatory state, while high-inflammation state is characterized by prolonged open chromatin after transcriptional termination. These findings demonstrate that two-dose vaccination stimulates persistent epigenetic remodeling of the innate immune cells and highlight the potential of temporal and spatial specific regulatory elements to optimizing vaccines.
Electrically tunable third-harmonic generation using intersubband polaritonic metasurfaces
Authors: Lee Jongwon , Park Seongjin , Yu Jaeyeon , Boehm Gerhard , Belkin Mikhail 
Published: January 2024

Abstract
Nonlinear intersubband polaritonic metasurfaces, which integrate giant nonlinear responses derived from intersubband transitions of multiple quantum wells (MQWs) with plasmonic nanoresonators, not only facilitate efficient frequency conversion at pump intensities on the order of few tens of kW cm− 2 but also enable electrical modulation of nonlinear responses at the individual meta-atom level and dynamic beam manipulation. The electrical modulation characteristics of the magnitude and phase of the nonlinear optical response are realized through the resonant properties of intersubband nonlinearity and Stark tunability. In this study, we report, for the first time, experimental implementations of electrical modulation characteristics of mid-infrared third-harmonic generation (THG) using an intersubband polaritonic metasurface based on MQW with Stark-tunable third-order nonlinear response. Experimentally, we achieved a 450% modulation depth of the THG signal, complete suppression of zero-order THG diffraction tuning based on local phase tuning exceeding 180 degrees, and THG beam steering using phase gradients. Our work proposes a new route for electrically tunable flat nonlinear optical elements with versatile functionalities.
Key determinants of health and wellbeing of dental nurses: a rapid review of over two decades of research
Authors: Opoku-Ansah Nana Adwoa , Gallagher Jennifer , Niven Victoria 
Published: January 2024

Abstract
Aim
To review the literature on the key determinants of health and well-being amongst dental nurses.
Method
Rapid review of the literature using Kangura’s approach across seven health and social science databases through OVID and the Cochrane Library, professional and health system databases. This approach was informed by past research done on other dental professionals. There was a two-stage review process where records were screened by the primary researcher with a second researcher independently reviewing 10% of the papers according to agreed inclusion and exclusion criteria by title, abstract and full text. Data extraction and qualitative synthesis of the included studies were done and quality assessment for risk of bias was made using a Mixed Methods Appraisal Tool.
Results
Out of 4,450 identified papers, 44 underwent full-text screening and 37 studies were included in the analysis. Four were of high quality, thirteen moderate-high, fourteen moderate-low and six low-quality studies. The overall well-being of dental nurses was good, and the determinants influencing well-being were grouped into micro-meso- and macro-level factors with evidence across the three domains. The determinant with the most evidence was workplace characteristics. Dental nurses with extended duties had higher job satisfaction. The COVID-19 pandemic caused an increase in anxiety, stress, burnout, and isolation among dental nurses.
Conclusion
The body of research indicates that dental nurses' health and well-being determinants are comparable to those of other dental professionals. Nurses in different countries had similar determinants. It is important to recognise and improve the determinants that affect their health and well-being to prevent burnout and exodus from the profession. There should be organisational and policy changes to help improve the well-being of dental nurses. Further investigation into dental nurses with longitudinal studies is needed.
Response of a phytoplankton community in a subtropical estuary to a pulse disturbance driven by a combo hurricane and rainfall event.
Authors: Quigg Antonietta , Claflin Noah , Kamalanathan Manoj , Labonté Jessica M. , Steichen Jamie L. 
Published: January 2024

Abstract
Water rather than wind was the major destructive force behind Hurricane Harvey, the category 4 storm that stalled over Texas in August 2017. Herein we present a unique examination of the phytoplankton community as it responded to the changing hydrodynamic conditions in Galveston Bay. We used traditional (primary productivity, pigments, Fluorescence Induction and Relaxation System, pulse-amplitude modulation fluorometer) and modern (imagining flow cytobot [IFCB], 16S rRNA and 18S rRNA gene sequencing) approaches to characterize the phytoplankton community and their physiological response. Phytoplankton communities transitioned from pre-storm estuarine to freshwater species and then began to transition back to an estuarine community with similar but not identical structure to that present before the storm. Further, phytoplankton communities were initially displaced by the flood waters, which lowered biomass and productivity despite the high nutrient concentrations and dissolved inorganic nitrogen to phosphate ratios of ~ 16. We found for cyanobacteria, factors such as time (i.e., sampling event after the storm), temperature (°C), salinity (psu), NH4+ (µM), NO3− (µM), and turbidity (Secchi and total suspended solids) were the most critical environmental factors that explained the variation in community composition relative to the major eukaryotic groups. Only factors such as time, followed by salinity, and NO3− played a crucial role for eukaryotes, with time having the most impact on diatoms. The results herein provide a greater understanding of the succession and natural variability of phytoplankton species following large flood events in subtropical estuaries, which are predicted to occur more frequently with increasing effects of climate change.
Report on simultaneous infection of rabbit haemorrhagic disease virus type 1 and type 2 in kits in China
Authors: Shi Lihui , Liu Yumei , Chang Chenhao , Wang Jianing , Zhang Zhikai , Wang Shuaishuai , zhang ziqiang 
Published: January 2024

Abstract
Diagnosis of the causes of rapid mortality in on rabbits was carried out on the basis of epidemiological and pathological profiling, using RT-PCR testing, gene sequencing and phylogenetic tree construction. In this experiment, samples were collected from two rabbit farms in Guizhou and Henan Provinces, China. Then the total RNA of liver tissue was extracted by Trizol method for RT-PCR amplification. The results showed that the specific target band was observed at 829 bp of RHDV2 and 591 bp of RHDV by agarose gel electrophoresis. Two different RT-PCR products amplified from one rabbit liver sample were named GZ-RHDV and GZ-RHDV2, respectively, and the other farm was named HN-RHDV and HN-RHDV2. Subsequently, four RT-PCR products amplified from two rabbit liver samples from different farms were selected for gene sequencing respectively, and the gene sequences were uploaded to NCBI for blast analysis. Finally, MEGA-7 software was used to construct the phylogenetic tree. The measured gene sequences were analysed by blast analysis and the amplification products in the liver samples showed a high degree of homology with domestic virus isolates. Among them, GZ-RHDV and HN-RHDV shared 98.50% and 98.69% homology with the Genbank accession number (MK814815.1), GZ-RHDV2 shared 99.35% homology with the Genbank accession number (OQ570963.1), and HN-RHDV2 shared 98.84% homology with the Genbank accession number (OQ570961.1). The above results confirmed that the cause of this mass mortality in rabbits on both farms was co-infection with RHDV and RHDV2. The sequenced liver samples from farms in Guizhou Province were selected to prepare virus suspension, and 60 day old rabbits immunized with RHDV vaccine were subcutaneously injected into the neck to identify the virulence of the virus. After 22 h, the infected rabbits developed typical clinical symptoms. For example, typical blood retention occurred in the mouth and nose, convulsions, opisthotonos, Mucoid secretion of anus, bleeding in liver, lung and heart, congestion and swelling in spleen were found during autopsy. The results showed that the classical vaccine had no protective effect on the mixed infection strain.
Association between smoking and Amnesia in Southwest Iran: Results from a Population-based Cohort Study
Authors: Cheraghian Bahman , Rahimi Zahra , Hashemi Seyed Jalal , Torabipour Amin 
Published: January 2024

Abstract

Background: Amnesia is a cognitive impairment that manifests as a deficit in the retrieval of previous memories and the acquisition of novel information. There is some evidence indicating that smoking might be linked to a greater likelihood of experiencing memory issues and cognitive decline, such as Amnesia. The purpose of this study was to explore the risk factors associated with Amnesia and the connection between smoking and Amnesia.
This population-based cross-sectional study
Methods: This population-based cross-sectional study was conducted at the baseline of the Hoveyzeh cohort study in adults aged 35-70 years in southwest Iran between 2016 and 2018. Information on socioeconomic factors, demographic characteristics, history of stroke, history of epilepsy, and history of head trauma was collected. We assessed the relationship between smoking and Amnesia. Multiple logistic regression was employed to account for potential confounding variables.
Results: The mean age of the participants was 48.8 ± 9.2 years, and 40.2% were male. The overall prevalence of Amnesia was 4.2% (95% CI 3.8–4.6). The odds of having Amnesia was significantly higher in smokers than nonsmokers (OR Adj=1.52 (95%CI:1.21–1.91)). Additionally, several other factors, including age, education level, type of residence, history of stroke, epilepsy, and history of trauma, were associated with Amnesia.
Conclusion: Our investigations revealed a direct correlation between smoking and Amnesia. To gain a more comprehensive understanding of the underlying mechanisms of these associations, it will be imperative to conduct future longitudinal studies.