bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY THE PERFORMANCE OF TWO-WHEELED BALANCING MOBILE ROBOT USING FUZZY PD CONTROLLER
Authors: Mohd Noor Nurul Muthmainnah , Mohd Halid Saiful Amirul Asyraf , Mahmod @Wahab Rohidatun 
Published: January 2024

Nowadays, the research on a two-wheeled self-balancing robot is an active area of research especially in terms of design as well as control to continue the innovation applications of robots in the future. Most of the two-wheeled self-balancing robots are designed based on an inverted pendulum system for stability and maneuverability. The aim of this paper is to propose the fuzzy PD controller to control and maintain its balance on the two wheels. A sensor of the Inertial Measurement Unit (IMU) was used as an input to evaluate and obtain the position and orientation of the robot. The control algorithms for the robot also are designed to keep the pendulum upright. Then, the fuzzy PD concept was applied to correct the error between the desired set point and the actual tilt angle position to adjust the speed of the motor accordingly. The results obtained from this controller were capable of maintaining the balancing of the robot by using an experimental method of PID tuning. The prototype of the two-wheeled self-balancing robot was implemented with Arduino Uno and a fuzzy PD controller. However, the limitation of the project is the longer size and heavier weight of the robot are less stable, then a better controller is needed to balance the robot.
Reduced-Size Antenna for Leadless Cardiac Pacemaker
Authors: DiviyaDevi Paramasivam  , Dewan Raimi , Nuradilah Yusri  
Published: January 2024

The advancement in technology led to the development of leadless cardiac pacemaker (LCP) systems that resolved the issues that arise due to the use of leads in the conventional pacemakers (CP). However, the compact size of the LCP system also requires a miniaturized antenna that can fit inside the limited space of the LCP. Therefore, this study was conducted to propose and design a reduced-size antenna that operates at 2.4 GHz. An implantable antenna with a footprint of 4.00 5.00 0.50 mm was designed using CST Microwave Studio (student version). An LCP system was integrated with the antenna and simulated inside the heart tissue model to evaluate the performance of the antenna. Based on the S11 parameter, the antenna was further optimized, and the coaxial-feed cable position was offset until the impedance matching was achieved for the resonant frequency to be at 2.4 GHz. The antenna exhibited good performance with a S11 of less than -10 dB at 2.4 GHz. In addition, the proposed antenna satisfies the requirements of LCP with limited space. Therefore, the proposed antenna is envisaged to be implemented for LCP systems.
Experiences of people with diabetes mellitus of telehealth for diabetes management during the COVID-19 pandemic: a qualitative systematic review protocol
Authors: Gerrie Alexander , Bellman Susan , Pollock Danielle 
Published: January 2024

Objective:
The objective of this review is to explore the experiences of people with diabetes who used telehealth for diabetes management due to COVID-19 pandemic protocols rather than traditional in-person consultations.

Introduction:
COVID-19 intensified globally from January 2020, eliciting a multinational response to infection control for health preservation, including social distancing in public areas and health care settings. The outcome had a significant impact on the health care system, where people with chronic diseases, such as those with diabetes, were required to transition most of their care to telehealth to align with social restrictions.

Inclusion criteria:
This review will include qualitative and mixed methods studies and theses of any research design and in any language that examine the experiences of adults with diabetes who transitioned from in-person consultations to telehealth during the COVID-19 pandemic. Exclusions will include pre-COVID-19 data; quantitative studies; and secondary, tertiary, and all other gray literature.

Methods:
A search of CINAHL (EBSCOhost), Scopus, Emcare (Ovid), Embase, PubMed (NCBI), and several ProQuest databases will be conducted. Studies from January 2020 onwards in any language will be assessed for inclusion. Two independent reviewers will retrieve and screen titles and abstracts and full-text studies, and assess the methodological quality of the included studies utilizing the JBI qualitative critical appraisal tool. The included studies will be synthesized utilizing JBI meta-aggregation, and the certainty of the findings will be assessed with ConQual.

Review registration:
PROSPERO CRD42023424667
Bi-level Analysis of Computed Tomography Images of Malignant Pleural Mesothelioma: Deep Learning-Based Classification and Subsequent Three-Dimensional Reconstruction
Authors: Weiss Cohen Miri , Ghidotti Anna , Regazzoni Daniele 
Published: January 2024

Abstract
A bi-level analysis of computed tomography (CT) images of malignant pleural mesothelioma (MPM) is presented in this paper, starting with a deep learning-based system for classification, followed by a three-dimensional (3D) reconstruction method. MPM is a highly aggressive cancer caused by asbestos exposure, and accurate diagnosis and determination of the tumor’s volume are crucial for effective treatment. The proposed system employs a bi-level approach, utilizing machine learning and deep learning techniques to classify CT lung images and subsequently calculate the tumor’s volume. The study addresses challenges related to deep neural networks, such as the requirement for large and diverse datasets, hyperparameter optimization, and potential data bias. To evaluate performance, two convolutional neural network (CNN) architectures, Inception-v3 and ResNet-50, were compared in terms of their features and performance. Based on CT images, the second stage incorporates 3D volume reconstruction. The process is carried out by cropping, registering, filtering, and segmenting images. This study demonstrated the efficacy of the developed system by combining CNN optimizations with 3D image reconstruction. It is intended to improve the accuracy of MPM diagnosis and to assist in the determination of chemotherapy doses, both of which may result in improved outcomes for patients.
Influence of Fixed Ring Gear Structural Compliance on the Quasi-Static and Dynamic Response of Epicyclic Gear Sets
Authors: Ryali Lokaditya , Talbot David 
Published: January 2024

AbstractThe structural compliance of annular ring gear can significantly influence the quasi-static and dynamic performance of an epicyclic gear set. As powertrain components are continually being optimized to their design limits, this influence becomes prominent and can no longer be ignored. The current paper will study the impact of ring gear compliance on the dynamic response of epicyclic gear sets in fixed ring kinematic configuration. To achieve this objective, the current study will incorporate a finite element–based ring gear formulation into the three-dimensional planetary load distribution model of Ryali and Talbot (2021, “A Dynamic Load Distribution Model of Planetary Gear Sets,” Mech. Mach. Theory, 158, p. 104229). The proposed model employs a modified simplex algorithm to iteratively solve for the elastic gear mesh contacts in conjunction with a numerical integration scheme, which enables it to inherently capture the influence of several components and system-level design variations. The developed formulation is used to conduct parametric studies involving different planetary gear designs, ring gear fixtures (bolted vs. splined), and operating conditions (quasi-static, dynamic). In the case of a splined ring gear fixture, an external splined tooth contact model is developed, which will be used to validate the model against the quasi-static experiments of Kahraman et al. (2010, “Influence of Ring Gear Rim Thickness on Planetary Gear Set Behavior,” ASME J. Mech. Des., 132(2), pp. 0210021–0210028). The discussed results demonstrate the fidelity of the developed model, thus making it an excellent tool for the design and analysis of planetary gears with thin annular ring gears.
Evolutionary radiation and microbial community dynamics shape the thermal tolerance of Fungiidae in the southern South China Sea
Authors: Wei Yuxin , Chen Biao , Yu Kefu , Liao Zhiheng , Yu Xiaopeng , Qin Zhenjun , Bao Zeming , Xu Lijia , Wang Yongzhi 
Published: January 2024

ABSTRACT

Fungiidae have shown increased thermal adaptability in coral reef ecosystems under global warming. This study analyzes the evolutionary divergence and microbial communities of Fungiidae in the Sanjiao Reef of the southern South China Sea and explores the impact of coral evolution radiation and microbial dynamics on the heat tolerance of Fungiidae. The results found that
Cycloseris
was an ancient branch of Fungiidae, dating back approximately 147.8953 Mya, and Fungiidae differentiated into two ancestral clades (clades I and II) before 107.0312 Ma. Fungiidae exhibited specific symbioses with the
Cladocopium
C27 sub-clade. Notably, the
Cladocopium
C1 sub-clade has a high relative abundance in clade I, whereas the heat-tolerant
Cladocopium
C40 and C3u sub-clades subdominante in clade II. Regarding bacterial communities,
Cycloseris costulata
, the earliest divergent species, had higher bacterial β-diversity, while the latest divergent species,
Lithophyllon scabra
, displayed lower bacterial α-diversity and higher community stability. Beneficial bacteria dominante Fungiidae’s bacterial community (54%). The co-occurrence network revealed that microbial networks in clade II exhibited lower complexity and greater resilience than those in clade I. Our study highlights that host evolutionary radiation and microbial communities shaped Fungiidae’s thermal tolerance. The variability in subdominant Symbiodiniaceae populations may contribute to interspecific differences in thermal tolerance along the evolutionary branches of Fungiidae. The presence of abundant beneficial bacteria may further enhance the thermal ability of the Fungiidae. Furthermore, the later divergent species of Fungiidae have stronger heat tolerance, possibly driven by the increased regulation ability of the host on the bacterial community, greater microbial community stability, and interaction network resistance.

IMPORTANCE
Coral reefs are facing significant threats due to global warming. The heat tolerance of coral holobionts depends on both the coral host and its microbiome. However, the association between coral evolutionary radiation and interspecific differences in microbial communities remains unclear. In this study, we investigated the role of evolutionary radiation and microbial community dynamics in shaping the thermal acclimation potential of Fungiidae in the Sanjiao Reef of the southern South China Sea. The study’s results suggest that evolutionary radiation enhances the thermal tolerance of Fungiidae. Fungiidae species that have diverged more recently have exhibited a higher presence of heat-tolerant Symbiodiniaceae taxa, more stable bacterial communities, and a robust and resilient microbial interaction network, improving the thermal adaptability of Fungiidae. In summary, this study provides new insights into the thermal adaptation patterns of corals under global warming conditions.
Defining the Role of Extrachromosomal DNA Amplifications in Medulloblastoma
Authors: Zhao Dacheng , Verhaak Roel G.W. 
Published: January 2024

Abstract
Circular extrachromosomal DNA (ecDNA), a common mechanism of oncogene amplification, has been identified as a major contributor to intratumoral heterogeneity and patient outcomes. In a recent publication in Nature Genetics, Chapman and colleagues further explored the role of ecDNA in the context of medulloblastoma. Using whole-genome sequencing, they found that 18% of the patients carry ecDNA amplification across a 468 medulloblastoma patient cohort. The presence of ecDNA was associated with worse survival. Single-cell FISH imaging and multiomic sequencing revealed that ecDNA copy number displayed a cell-to-cell variability within the sample, contributing to tumor heterogeneity. Furthermore, through sequencing and CRISPRi experiments, the authors uncovered frequent enhancer rewiring events on ecDNA that drive proliferation.
OPW and de Ste. Croix: the Past and Present Views of a Pupil
Authors: Lane Fox Robin 
Published: January 2024

Abstract
This survey, by a pupil of Geoffrey de Ste. Croix and eventual successor in his Oxford job, combines personal recollections of de Ste. Croix’s horizons and intellectual range with a penetrating study of his Origins of the Peloponnesian War, its underlying debts and detailed contentions. It addresses his, and Thucydides’, engagement with origins and causes, his central contention about votes by the Spartans and their allies on whether to go to war, the roles of Corinth, Megara and the much-discussed Megarian decree. It also presents a close reading of an Athenian involvement in Macedon and the north and its relevance to de Ste. Croix’s views on Athenian imperialism. It then sets the book’s conclusions in a wider context, ranging from modern writings on the origins of war to its concluding echo of Lenin.
Lettre de Ladislas Mickiewicz. List Władysława Mickiewicza. Letter of Władysław Mickiewicz
Authors: Sajkowski Wojciech 
Published: January 2024

The text is a transcription and translation into Polish and English of a French-language letter from Wladysław Mickiewicz (1838–1926), son of the great poet, Adam Mickiewicz (1798–1855), to the Bulgarian poet, modernist associated with the group “Thought” and the magazine Mis'l [Thought] (1892–1907).
Robot-assisted partial nephrectomy using the novel Hugo™ RAS system: Feasibility, setting and perioperative outcomes of the first off-clamp series
Authors: Prata F , Ragusa A , Civitella A , Tuzzolo P , Tedesco F , Cacciatore L , Iannuzzi A , Callè P , Raso G , Fantozzi M , Pira M , Ricci M , Pino M , Minore A , Basile S , Testa A , Crimi VG , Deanesi N , Travino A , D’Addurno G , Scarpa RM , Papalia R 
Published: January 2024

Introduction: Hugo Robot-Assisted Surgery (RAS) System has been conceived with enhanced modularity but its role for nephron-sparing surgery setting still remains poorly explored. We aimed to describe our experience in robot-assisted partial nephrectomy (RAPN) with a three-arms setting for the first off-clamp series using the new Hugo RAS System. Methods: Patients were placed on an extended flank position at the margin of the surgical bed with a slightly flexion (45°). The first 11 mm robotic trocar (camera port) was placed along the pararectal line 14 ± 2 cm far from the umbilicus. The pneumoperitoneum was then induced through the AirSeal system (SurgiQuest, Milford, Connecticut, USA©). Two more 8 mm operative robotic ports were placed under direct vision, either 8 ± 1 cm far from optic’s port. Two 12 mm laparoscopic ports for bed-assistant were placed between robotic ports. Monopolar curved shears, fenestrated grasper, and large needle driver were used in a three-instruments configuration. Results: Off-clamp RAPN was successfully performed in seven patients with cT1 renal masses using a trans-peritoneal route. Median port placement and docking time was 6 min (IQR, 4–8 min). Hemostasis was achieved through renorraphy using a single transfix stitch with sliding clips technique. There was no need for additional ports placement. No intraoperative complications occurred, no clashing of robotic instruments or between the robotic arms was observed. No technical failures of the system occurred. Median console time was 83 min (IQR, 68–115 min). Median estimated blood loss were 200 ml (IQR, 50–400 ml). All patients were discharged between post-operative day 2 and 3, without the need of hospital readmission. No complications were recorded within the first 30 post-operative days. Conclusions: We performed the first series of off-clamp RAPN using the novel HUGO RAS System. This novel robotic platform showed an easy-friendly docking system, providing excellent perioperative outcomes with a simple three-arms configuration.
Periprocedural thromboembolic complications of LEO baby stent in endovascular treatment of intracranial aneurysms: Experience in 149 patients
Authors: Shen Yunan , Ni Heng , Jia Zhenyu , Cao Yuezhou , Lu Guangdong , Liu Xinglong , Wang Bin , Zhou Chun , Shi Haibin , Liu Sheng , Zhao Linbo 
Published: January 2024

Objective To report periprocedural thromboembolic complications of LEO Baby stent-assisted coiling of wide-necked intracranial aneurysms and to analyze the possible influencing factors. Methods We retrospectively identified 149 patients with aneurysms who underwent LEO Baby stent-assisted embolization between October 2018 and March 2022. Clinical and radiographic data of patients were reviewed to determine whether a thromboembolic event had occurred. Multivariate logistic analysis was performed to identify significant factors associated with thromboembolic events. Results Successful stent deployment of the stent was achieved in all patients in the target artery. There were 66 patients (44.3%) with acutely ruptured aneurysms and 83 patients (55.7%) with unruptured aneurysms. Fourteen (9.4%, 95% confidence interval: 4.7%–14.1%) patients were confirmed to have developed a thromboembolic event, including nine patients with acute intraoperative thrombosis and five patients with postoperative thromboembolic events. The rate of thromboembolic events was 6.0% (5/83) in patients with unruptured aneurysms and 13.6% (9/66) in patients with acutely ruptured aneurysms. There was a trend toward an increased rate of thromboembolic events in patients with acute ruptured aneurysms ( p = 0.087). Thromboembolic events were significantly associated with the parent-artery diameter ( p = 0.010). Conclusions Our study demonstrates a low rate of thromboembolic complications in unruptured aneurysms treated with LEO Baby stent. Thromboembolic events appear to be more common in ruptured aneurysms. A small diameter of the parent artery is associated with an increased risk of thromboembolic complications, and more relevant studies are still needed.
The Role of Age, University Attendance and Other Demographic Factors in Experiencing Emerging Adulthood
Authors: Kohútová Veronika , Kohút Michal 
Published: January 2024

There is an ongoing debate about the importance of university attendance, age, life transitions and other demographic factors on experiencing the emerging adulthood. The present study aims to explore the effect of demographics (age, college attendance, subjective economic status, financial independence, living conditions, relationship status or having a child) on the emerging adulthood. Slovak adults ( N = 800), between 18 to 29 years old, reported their demographics and completed the Inventory of dimensions of emerging adulthood. The results showed slight differences between those who attended university and those who did not - mainly in experimentation, however, both groups experienced the features of emerging adulthood. Age makes a greater difference, which might be connected to parenthood, relationship status and living conditions.
MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken
Authors: Cai Bolin , Ma Manting , Yuan Rongshuai , Zhou Zhen , Zhang Jing , Kong Shaofen , Lin Duo , Lian Ling , Li Juan , Zhang Xiquan , Nie Qinghua 
Published: January 2024

Abstract
Background
Skeletal muscle development is pivotal for animal growth and health. Recently, long noncoding RNAs (lncRNAs) were found to interact with chromatin through diverse roles. However, little is known about how lncRNAs act as chromatin-associated RNAs to regulate skeletal muscle development. Here, we aim to investigate the regulation of chromatin-associated RNA (MYH1G-AS) during skeletal muscle development.

Methods
We provided comprehensive insight into the RNA profile and chromatin accessibility of different myofibers, combining RNA sequencing (RNA-seq) with an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). The dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay were used to analyze the transcriptional regulation mechanism of MYH1G-AS. ALKBH5-mediated MYH1G-AS N6-methyladenosine (m6A) demethylation was assessed by a single-base elongation and ligation-based qPCR amplification method (SELECT) assay. Functions of MYH1G-AS were investigated through a primary myoblast and lentivirus/cholesterol-modified antisense oligonucleotide (ASO)-mediated animal model. To validate the interaction of MYH1G-AS with fibroblast growth factor 18 (FGF18) protein, RNA pull down and an RNA immunoprecipitation (RIP) assay were performed. Specifically, the interaction between FGF18 and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) protein was analyzed by coimmunoprecipitation (Co-IP) and a yeast two-hybrid assay.

Results
A total of 45 differentially expressed (DE) lncRNAs, with DE ATAC-seq peaks in their promoter region, were classified as open chromatin-associated lncRNAs. A skeletal muscle-specific lncRNA (MSTRG.15576.9; MYH1G-AS), which is one of the open chromatin-associated lncRNA, was identified. MYH1G-AS transcription is coordinately regulated by transcription factors (TF) SMAD3 and SP2. Moreover, SP2 represses ALKBH5 transcription to weaken ALKBH5-mediated m6A demethylation of MYH1G-AS, thus destroying MYH1G-AS RNA stability. MYH1G-AS accelerates myoblast proliferation but restrains myoblast differentiation. Moreover, MYH1G-AS drives a switch from slow-twitch to fast-twitch fibers and causes muscle atrophy. Mechanistically, MYH1G-AS inhibits FGF18 protein stabilization to reduce the interaction of FGF18 to SMARCA5, thus repressing chromatin accessibility of the SMAD4 promoter to activate the SMAD4-dependent pathway.

Conclusions
Our results reveal a new pattern of the regulation of lncRNA expression at diverse levels and help expound the regulation of m6A methylation on chromatin status.

Graphical Abstract
Ionome mapping and amino acid metabolome profiling of Phaseolus vulgaris L. seeds imbibed with computationally informed phytoengineered copper sulphide nanoparticles
Authors: Botha Nandipha L. , Cloete Karen J. , Šmit Žiga , Isaković Kristina , Akbari Mahmood , Morad Razieh , Madiba Itani , David Oladipupo Moyinoluwa , Santos Luis P. M. , Dube Admire , Pelicon Primoz , Maaza Malik 
Published: January 2024

AbstractThis study reports the effects of a computationally informed and avocado-seed mediated Phyto engineered CuS nanoparticles as fertilizing agent on the ionome and amino acid metabolome of Pinto bean seeds using both bench top and ion beam analytical techniques. Physico-chemical analysis of the Phyto engineered nanoparticles with scanning-electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier Transform Infrared Spectroscopy confirmed the presence of CuS nanoparticles. Molecular dynamics simulations to investigate the interaction of some active phytocompounds in avocado seeds that act as reducing agents with the nano-digenite further showed that 4-hydroxybenzoic acid had a higher affinity for interacting with the nanoparticle’s surface than other active compounds. Seeds treated with the digenite nanoparticles exhibited a unique ionome distribution pattern as determined with external beam proton-induced X-ray emission, with hotspots of Cu and S appearing in the hilum and micropyle area that indicated a possible uptake mechanism via the seed coat. The nano-digenite also triggered a plant stress response by slightly altering seed amino acid metabolism. Ultimately, the nano-digenite may have important implications as a seed protective or nutritive agent as advised by its unique distribution pattern and effect on amino acid metabolism.
Graphical abstract