bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of physiotherapist managers in Ireland and their views on the role of Advanced Practice Physiotherapists
Authors: Ó Mír Marie , Casey Maire‐Brid , Smart Keith M. 
Published: December 2023

AbstractBackgroundWithin the current context of implementation of an Advanced Practice Grade, the Irish Society of Chartered Physiotherapists commissioned a survey of physiotherapy manager opinions regarding the role of Advanced Practice Physiotherapists.ObjectivesThe aim of this survey was to explore the views of physiotherapist managers in relation to the characteristics, role, competencies and management of Advanced Practice Physiotherapists (APPs) in Ireland.MethodsPhysiotherapist managers based in primary and secondary care settings in Ireland were invited to participate in a survey on Advanced Practice. Quantitative data from a custom designed online survey was analysed with descriptive statistics and qualitative data from open‐ended survey questions were analysed using thematic analysis.ResultsThe response rate to the survey was 32% (24/75). On average, respondents thought that 54% (range: 15%–80%) of an APPs time should be spent in clinical practice and between 17% and 20% variously on managerial and leadership, teaching and education and research and development duties. Four themes were identified from the surveys' open‐ended questions related to the description of APP: ‘Extended scope ‘Advanced clinical training, knowledge, and decision‐making’, ‘Autonomy, independence and responsibility’, and ‘Wider roles’.ConclusionIrish physiotherapist managers recognised the extended scope of practice, expertise and multiple roles characteristic of APPs. They indicated the need for legislative changes and clarity around governance.
An intrinsic network of polar interactions is responsible for binding of UL49.5 C‐degron by the CRL2KLHDC3 ubiquitin ligase
Authors: Ślusarz Magdalena J. , Lipińska Andrea D. 
Published: December 2023

AbstractBovine herpesvirus type 1 (BoHV‐1) is a pathogen of cattle responsible for infectious bovine rhinotracheitis. The BoHV‐1 UL49.5 is a transmembrane protein that binds to the transporter associated with antigen processing (TAP) and downregulates cell surface expression of the antigenic peptide complexes with the major histocompatibility complex class I (MHC‐I). KLHDC3 is a kelch domain‐containing protein 3 and a substrate receptor of a cullin2‐RING (CRL2) E3 ubiquitin ligase. Recently, it has been identified that CRL2KLHDC3 is responsible for UL49.5‐triggered TAP degradation via a C‐degron pathway and the presence of the degron sequence does not lead to the degradation of UL49.5 itself. The molecular modeling of KLHDC3 in complexes with four UL49.5 C‐terminal decapeptides (one native protein and three mutants) revealed their activity to be closely correlated with the conformation which they adopt in KLHDC3 binding cleft. To analyze the interaction between UL49.5 and KLHDC3 in detail, in this work a total of 3.6 μs long molecular dynamics simulations have been performed. The complete UL49.5‐KLHDC3 complexes were embedded into the fully hydrated all‐atom lipid membrane model with explicit water molecules. The network of polar interactions has been proposed to be responsible for the recognition and binding of the degron in KLHDC3. The interaction network within the binding pocket appeared to be very similar between two CRL2 substrate receptors: KLHDC3 and KLHDC2.
Improving the representation of the atmospheric boundary layer by direct assimilation of ground‐based microwave radiometer observations
Authors: Vural Jasmin , Merker Claire , Löffler Moritz , Leuenberger Daniel , Schraff Christoph , Stiller Olaf , Schomburg Annika , Knist Christine , Haefele Alexander , Hervo Maxime 
Published: December 2023

AbstractIn a joint effort, MeteoSwiss and Deutscher Wetterdienst (DWD) address the need for improving the initial state of the atmospheric boundary layer (ABL) by exploiting ground‐based profiling observations that aim to fill the existing observational gap in the ABL. We implemented brightness‐temperature observations from ground‐based microwave radiometers (MWRs) in our data assimilation systems using a local ensemble transform Kalman filter (LETKF) with Radiative Transfer for TIROS Operational Vertical Sounder, ground‐based (RTTOV‐gb) as a forward operator. We were able to obtain a positive impact on the brightness temperature first guess and analysis, as well as a slight impact on the ABL humidity, using two MWRs at MeteoSwiss. These results led to a subsequent operational implementation of the observing system at MeteoSwiss. Furthermore, we performed an extensive set of assimilation experiments at DWD to investigate further various aspects such as the vertical localisation of selected single channels. We obtained a positive impact on the 6‐hr forecast of ABL temperature and humidity by assimilating two channels employing a dynamical localisation based on the sensitivity functions of RTTOV‐gb but also with a static localisation in a single‐channel setup. Our experiments indicate the importance of vertical localisation when using more than one channel, although reliable improvements are challenging to obtain without a larger number of observations for both assimilation and verification.
Scimitar syndrome, bronchiectasis, haemoptysis and a pneumonectomy
Authors: Jeffs Emma , Lee Hyukjoon , Beckert Lutz 
Published: December 2023

AbstractScimitar syndrome is a rare condition characterized by partial or complete anomalous pulmonary venous drainage of the lung to the inferior vena cava, right lung hypoplasia and dextroposition of the heart. Haemoptysis is uncommon in adults, although the clinical spectrum is wide. We report a case of a 38‐year‐old male with scimitar syndrome who had low grade haemoptysis persisting over several years secondary to bronchiectatic changes in his hypoplastic right lung. Conservative measures to manage haemoptysis were unsuccessful and the patient proceeded to bronchial artery embolization. The post‐procedure course was complicated by lung infarction and the patient ultimately required pneumonectomy. Deformities of the blood vessels and lungs are complex in scimitar syndrome. Bronchial artery embolization should be approached cautiously to protect pulmonary perfusion.
Delivery of average assured pressure support (AVAPS) through tracheostomy in paediatric patients
Authors: Saddi Vishal , O'Connor Antonia , Thambipillay Ganesh , Teng Arthur 
Published: December 2023

AbstractAverage volume‐assured pressure support (AVAPS) mode has been available since 2009 and allows the ventilator to deliver a constant pre‐set tidal volume by automatically adjusting the inspiratory pressures within a set range. Data in AVAPS mode use is limited in both paediatric populations, and in patients who are ventilated through a tracheostomy. This case series reports on the successful use of AVAPS mode in four paediatric patients with tracheostomy ventilation.
Camtrap DP: an open standard for the FAIR exchange and archiving of camera trap data
Authors: Bubnicki Jakub W. , Norton Ben , Baskauf Steven J. , Bruce Tom , Cagnacci Francesca , Casaer Jim , Churski Marcin , Cromsigt Joris P. G. M. , Farra Simone Dal , Fiderer Christian , Forrester Tavis D. , Hendry Heidi , Heurich Marco , Hofmeester Tim R. , Jansen Patrick A. , Kays Roland , Kuijper Dries P. J. , Liefting Yorick , Linnell John D. C. , Luskin Matthew S. , Mann Christopher , Milotic Tanja , Newman Peggy , Niedballa Jürgen , Oldoni Damiano , Ossi Federico , Robertson Tim , Rovero Francesco , Rowcliffe Marcus , Seidenari Lorenzo , Stachowicz Izabela , Stowell Dan , Tobler Mathias W. , Wieczorek John , Zimmermann Fridolin , Desmet Peter 
Published: December 2023

AbstractCamera trapping has revolutionized wildlife ecology and conservation by providing automated data acquisition, leading to the accumulation of massive amounts of camera trap data worldwide. Although management and processing of camera trap‐derived Big Data are becoming increasingly solvable with the help of scalable cyber‐infrastructures, harmonization and exchange of the data remain limited, hindering its full potential. There is currently no widely accepted standard for exchanging camera trap data. The only existing proposal, “Camera Trap Metadata Standard” (CTMS), has several technical shortcomings and limited adoption. We present a new data exchange format, the Camera Trap Data Package (Camtrap DP), designed to allow users to easily exchange, harmonize and archive camera trap data at local to global scales. Camtrap DP structures camera trap data in a simple yet flexible data model consisting of three tables (Deployments, Media and Observations) that supports a wide range of camera deployment designs, classification techniques (e.g., human and AI, media‐based and event‐based) and analytical use cases, from compiling species occurrence data through distribution, occupancy and activity modeling to density estimation. The format further achieves interoperability by building upon existing standards, Frictionless Data Package in particular, which is supported by a suite of open software tools to read and validate data. Camtrap DP is the consensus of a long, in‐depth, consultation and outreach process with standard and software developers, the main existing camera trap data management platforms, major players in the field of camera trapping and the Global Biodiversity Information Facility (GBIF). Under the umbrella of the Biodiversity Information Standards (TDWG), Camtrap DP has been developed openly, collaboratively and with version control from the start. We encourage camera trapping users and developers to join the discussion and contribute to the further development and adoption of this standard.
Growth of BiSBr Microsheet Arrays for Enhanced Photovoltaics Performance
Authors: Li Sen , Huang Zhiyuan , Ding Yafei , Zhang Chao , Yu Jingyan , Feng Qi , Feng Jun 
Published: December 2023

AbstractIn this study, single‐crystalline BiSBr is synthesized using a solution‐based approach and conducted a systematic characterization of its photoelectric properties and photovoltaic performances. UV photoelectron spectroscopy and density functional theory (DFT) calculations reveal that BiSBr is an indirect p‐type semiconductor, characterized by distinct positions and compositions of the valence band maximum and conduction band minimum. The BiSBr single crystal microrod features a significant electrical conductivity of 14 800 S m−1 along the c‐axis, denoting minimal carrier resistance in this direction. For photovoltaic performance assessment, the authors successfully fabricated two homogeneous BiSBr films on TiO2 porous substrates: A microsheet array film via physical vapor deposition (PVD) and solvothermal treatment, and a BiSBr microsheet film via PVD and thermal treatment. The solar cell, comprising a BiSBr microsheet array film with an architecture of fluorine‐doped tin oxide FTO/TiO2/BiSBr/(I3−/I−)/Pt, demonstrated a power conversation efficiency of 1.40%, ≈11 times that of BiSBr microsheet film counterpart. These preliminary results underscore the potential of BiSBr microsheet arrays, producible through low‐cost solution processes, as adept light absorbers, enhancing photovoltaic efficiency through effective light scattering and promoting efficient electron‐hole separation and transport.
Parsing millions of URLs per second
Authors: Nizipli Yagiz , Lemire Daniel 
Published: December 2023

AbstractURLs are fundamental elements of web applications. By applying vector algorithms, we built a fast standard‐compliant C++ implementation. Our parser uses three times fewer instructions than competing parsers following the WHATWG standard (e.g., Servo's rust‐url) and up to eight times fewer instructions than the popular curl parser. The Node.js environment adopted our C++ library. In our tests on realistic data, a recent Node.js version (20.0) with our parser is four to five times faster than the last version with the legacy URL parser.
Exploration of SERPINA family functions and prognostic value in breast cancer based on transcriptome and in vitro analysis
Authors: Yu Qiyi , Xie Tianyuan , Zhang Yidong , Pan Tianyue , Tan Yongmei , Qin Hai , Yan Simin 
Published: December 2023

AbstractBreast cancer poses a significant risk to women worldwide, yet specific role of SERPINA gene family in breast cancer remains unclarified. Data were collected from online databases. SERPINA family gene expression was presented, and prognosis value was evaluated. Multi‐omics methods were employed to explore the SERPINA‐related biological processes, followed by comprehensive analyses of their roles in breast cancer. Single‐cell data were analyzed to characterize the SERPINA family gene expression in different cell clusters. We selected SERPINA5 as the target gene. Via pan‐cancer analysis, SERPINA5 was also investigated in various cancers. The experimental validation was conducted in MDA‐MB‐231 cell line eventually. SERPINA family showed differential expression in breast cancer, which were mainly expressed in myeloid cells, epithelial cells, and dendritic cells. SERPINA5 expression was upregulated in breast cancer, which was associated with a better prognosis. Immune infiltration illustrated the positive correlativity between SERPINA5 intensity and eosinophilic recruitment. Pan‐cancer analysis indicated the function of SERPINA5 as a potential biomarker in other cancers. Finally, experimental validation demonstrated that SERPINA5 contributes to lower invasion and metastatic potential of breast cancer cells. With bioinformatics analysis, the significant role SERPINA family genes functioned in breast cancer was comprehensively explored, with SERPINA5 emerging as a key gene in suppressing breast cancer progression.
Use of continuous genotypes for genomic prediction in sugarcane
Authors: Yadav Seema , Ross Elizabeth M. , Wei Xianming , Liu Shouye , Nguyen Loan To , Powell Owen , Hickey Lee T. , Deomano Emily , Atkin Felicity , Voss‐Fels Kai P. , Hayes Ben J. 
Published: December 2023

AbstractGenomic selection in sugarcane faces challenges due to limited genomic tools and high genomic complexity, particularly because of its high and variable ploidy. The classification of genotypes for single nucleotide polymorphisms (SNPs) becomes difficult due to the wide range of possible allele dosages. Previous genomic studies in sugarcane used pseudo‐diploid genotyping, grouping all heterozygotes into a single class. In this study, we investigate the use of continuous genotypes as a proxy for allele‐dosage in genomic prediction models. The hypothesis is that continuous genotypes could better reflect allele dosage at SNPs linked to mutations affecting target traits, resulting in phenotypic variation. The dataset included genotypes of 1318 clones at 58K SNP markers, with about 26K markers filtered using standard quality controls. Predictions for tonnes of cane per hectare (TCH), commercial cane sugar (CCS), and fiber content (Fiber) were made using parametric, non‐parametric, and Bayesian methods. Continuous genotypes increased accuracy by 5%–7% for CCS and Fiber. The pseudo‐diploid parametrization performed better for TCH. Reproducing kernel Hilbert spaces model with Gaussian kernel and AK4 (arc‐cosine kernel with hidden layer 4) kernel outperformed other methods for TCH and CCS, suggesting that non‐additive effects might influence these traits. The prevalence of low‐dosage markers in the study may have limited the benefits of approximating allele‐dosage information with continuous genotypes in genomic prediction models. Continuous genotypes simplify genomic prediction in polyploid crops, allowing additional markers to be used without adhering to pseudo‐diploid inheritance. The approach can particularly benefit high ploidy species or emerging crops with unknown ploidy.
The risk of pet animals in spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and public health importance: An updated review
Authors: Salajegheh Tazerji Sina , Gharieb Rasha , Ardestani Mohammadreza Manouchehri , Akhtardanesh Baharak , Kabir Farrokhreza , Vazir Bita , Duarte Phelipe Magalhães , Saberi Niloufar , Khaksar Ehsan , Haerian Sadegh , Fawzy Mohamed 
Published: December 2023

AbstractSince the outbreak of SARS‐CoV‐2 was first identified in 2019, it has been reported that the virus could infect a variety of animals either naturally or experimentally. This review discusses the occurrence SARS‐CoV‐2 in dogs and cats and the role of these animals in transmitting coronavirus disease 2019 (COVID‐19) to their owners. The data were collected from epidemiological studies and case reports that focused on studying the occurrence of SARS‐CoV‐2 in pet animals and their owners. Epidemiological studies and case reports indicate that dogs and cats are infected with SARS‐CoV‐2 either naturally or experimentally; however, the global number of naturally infected animals is far lower than the number of people who have COVID‐19. These studies demonstrate that pet animals acquire the infection from direct contact with COVID‐19‐infected owners. Currently, there are no studies reporting that dogs and cats can transmit SARS‐CoV‐2 to other animals and humans, under natural conditions. The emergence of SARS‐CoV‐2 infection in companion animals (dogs and cats) in different countries worldwide raises concerns that pets are at higher risk for spreading and transmitting SARS‐CoV‐2 to humans and other animals, which poses a hazard to the public health. Therefore, investigating the role of dogs and cats in the transmission and epidemiology of SARS‐CoV‐2 will help us to design and implement appropriate preventive measures against the further transmission of SARS‐CoV‐2.
Sociology Precursors: From Scientific Positivism to the “Mexican Renaissance” (1856–1930)
Authors: Zabludovsky Gina 
Published: December 2023

AbstractThe chapter analyses two periods. During the first period (1856–1910), sociology and positivism acquired exceptional relevance as an intellectual and governmental discourse to legitimize science, the separation of church and state, and the importance of secular and free education. The second part deals with the aftermath of the Mexican Revolution (1910–1920), the revolt against positivism, and the search of a new national identity through cultural expression and a new interest in anthropology over sociology.
The Expansion of Sociology in Mexico (1959–1980)
Authors: Zabludovsky Gina 
Published: December 2023

AbstractAt the end of the 1950s, Mexico faced unfavorable economic conditions, and the protest of different labor movements, which aroused a new concern for social inequality in the country. In 1968, the violent governmental reaction to the student movement changed the vision of a peaceful progress according to the so-called “Mexican Miracle.” Under the new social circumstances and the expectations generated by the outbreak of the Cuban Revolution, the decade of the 1970s was characterized by the eruption of Marxism in the universities. Due to the rise of authoritarianism and the growth of military regimes in Latin America, many South American intellectuals arrived at Mexico as professors in the social science departments. Sociology experienced a process of expansion both in student enrollment and in the founding of journals and new academic institutions. The chapter analyses these transformations together with the changes to the sociology curricula, in the main journals, and publications, in the studies undertaken by Mexican sociologists, as well as the contributions from foreign authors that had an important impact in Mexican social science.
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Authors: Jiang Yangjing , Liang Min , Chen Long , Wang Jian , Huang Yijie , Huo Huanhuan , Xiao Danrui , Hu Yunwen , Wang Zi , Ji Qingqi , Li Yanjie , Cai Zhaohua , He Ben 
Published: December 2023

AbstractObesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue and leads to elevated cytokines such as interleukin-1β (IL-1β) in the circulation and tissues. Previous studies demonstrate that SENP3, a redox-sensitive SUMO2/3-specific protease, is strongly implicated in the development and progression of cancer and cardiovascular diseases. However, the role of SENP3 in obesity-associated inflammation remains largely unknown. To better understand the effects of SENP3 on adipose tissue macrophage (ATM) activation and function within the context of obesity, we generated mice with myeloid-specific deletion of SENP3 (Senp3flox/flox;Lyz2-Cre mice). We found that the expression of SENP3 is dramatically increased in ATMs during high-fat diet (HFD)-induced obesity in mice. Senp3flox/flox;Lyz2-Cre mice show lower body weight gain and reduced adiposity and adipocyte size after challenged with HFD and during aging. Myeloid-specific SENP3 deletion attenuates macrophage infiltration in adipose tissue and reduces serum levels of inflammatory factors during diet and age-induced obesity. Furthermore, we found that SENP3 knockout markedly inhibits cytokine release from macrophage after lipopolysaccharide and palmitic acid treatment in vitro. Mechanistically, in cultured peritoneal macrophages, SENP3 protein level is enhanced by IL-1β, in parallel with the upregulation of Yes-associated protein 1 (YAP1). Moreover, we demonstrated that SENP3 modulates de-SUMO modification of YAP1 and SENP3 deletion abolishes the upregulation of YAP1 induced by IL-1β. Most importantly, SENP3 deficiency reduces YAP1 protein level in adipose tissue during obesity. Our results highlight the important role of SENP3 in ATM inflammation and diet and age-induced obesity.
Geodesics orbiting a singularity
Authors: Grieser Daniel , Lye Jørgen Olsen 
Published: December 2023

AbstractWe study the behaviour of geodesics on a Riemannian manifold near a generalized conical or cuspidal singularity. We show that geodesics entering a small neighbourhood of the singularity either hit the singularity or approach it to a smallest distance $$\delta $$
δ
and then move away from it, winding around the singularity a number of times. We study the limiting behaviour $$\delta \rightarrow 0$$

δ
→
0

in the second case. In the cuspidal case the number of windings goes to infinity as $$\delta \rightarrow 0$$

δ
→
0

, and we compute the precise asymptotic behaviour of this number. The asymptotics have explicitly given leading term determined by the warping factor that describes the type of cuspidal singularity. We also discuss in some detail the relation between differential and metric notions of conical and cuspidal singularities.
Moment functions of higher rank on some types of hypergroups
Authors: Fechner Żywilla , Gselmann Eszter , Székelyhidi László 
Published: December 2023

AbstractWe consider moment functions of higher order. In our earlier paper, we have already investigated the moment functions of higher order on groups. The main purpose of this work is to prove characterization theorems for moment functions on the multivariate polynomial hypergroups and on the Sturm–Liouville hypergroups. In the first case, the moment generating functions of higher rank are partial derivatives (taken at zero) of the composition of generating polynomials of the hypergroup and functions whose coordinates are given by the formal power series. On Sturm–Liouville hypergroups the moment functions of higher rank are restrictions of even smooth functions that also satisfy certain boundary value problems. The second characterization of moment functions of higher rank on Sturm–Liouville hypergroups is given by means of an exponential family. In this case, the moment functions of higher rank are partial derivatives of an appropriately modified exponential family again taken at zero.