bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unsupervised domain adaptive bearing fault diagnosis based on maximum domain discrepancy
Authors: Wang Cuixiang , Wu Shengkai , Shao Xing 
Published: January 2024

AbstractIn the existing domain adaptation-based bearing fault diagnosis methods, the data difference between the source domain and the target domain is not obvious. Besides, parameters of target domain feature extractor gradually approach that of source domain feature extractor to cheat discriminator which results in similar feature distribution of source domain and target domain. These issues make it difficult for the domain adaptation-based bearing fault diagnosis methods to achieve satisfactory performance. An unsupervised domain adaptive bearing fault diagnosis method based on maximum domain discrepancy (UDA-BFD-MDD) is proposed in this paper. In UDA-BFD-MDD, maximum domain discrepancy is exploited to maximize the feature difference between the source domain and target domain, while the output feature of target domain feature extractor can cheat the discriminator. The performance of UDA-BFD-MDD is verified through comprehensive experiments using the bearing dataset of Case Western Reserve University. The experimental results demonstrate that UDA-BFD-MDD is more stable during training process and can achieve higher accuracy rate.
Edge-aware nonlinear diffusion-driven regularization model for despeckling synthetic aperture radar images
Authors: Bua Anthony , Kapyela Goodluck , Massawe Libe , Maiseli Baraka 
Published: January 2024

AbstractSpeckle noise corrupts synthetic aperture radar (SAR) images and limits their applications in sensitive scientific and engineering fields. This challenge has attracted several scholars because of the wide demand of SAR images in forestry, oceanography, geology, glaciology, and topography. Despite some significant efforts to address the challenge, an open-ended research question remains to simultaneously suppress speckle noise and to restore semantic features in SAR images. Therefore, this work establishes a diffusion-driven nonlinear method with edge-awareness capabilities to restore corrupted SAR images while protecting critical image features, such as contours and textures. The proposed method incorporates two terms that promote effective noise removal: (1) high-order diffusion kernel; and (2) fractional regularization term that is sensitive to speckle noise. These terms have been carefully designed to ensure that the restored SAR images contain stronger edges and well-preserved textures. Empirical results show that the proposed model produces content-rich images with higher subjective and objective values. Furthermore, our model generates images with unnoticeable staircase and block artifacts, which are commonly found in the classical Perona–Malik and Total variation models.
Photovoltaics in agricultural landscapes: “Industrial land use” or a “real compromise” between renewable energy and biodiversity? Perspectives of German nature conservation associations
Authors: Hilker Janna Marie , Busse Maria , Müller Klaus , Zscheischler Jana 
Published: January 2024

Abstract
Background
One common renewable energy source for substituting fossil sources is photovoltaic (PV) systems. However, installing PV systems in agricultural areas can lead to competition with other land uses. These projects, therefore, often encounter problems with social acceptance in affected communities. Especially from the perspective of nature conservation targets, conflicts can arise. These potential differences are still under-researched but represent important knowledge for the societally broadly accepted design of such facilities and their contribution to energy transformation. In this paper, we investigate the perspectives of nature conservationists on PV in the region of Brandenburg, Germany. We comparatively analyse attitudes towards ground-mounted photovoltaics (GM-PV) and agrophotovoltaics (APV). APV combines energy supply and agricultural production on the same land and could thus be a possible solution for mitigating land-use conflicts.

Results
We investigated the degree of local acceptability and positive and negative influencing factors through a qualitative text analysis of ten interviews with local representatives and position papers by Nature Conservation Associations. Our findings show a growing consensus around basic assumptions of the need for renewable energies, the prioritised support for PV systems on rooftops over the installation on agricultural land (GM-PV and APV), and the necessity for PV systems to be compatible with nature conservation objectives. Regarding specific site decisions on agricultural land, we find diverging attitudes when comparing the content of position papers and the responses of interviewees. The interviewees advocate taking into account local interests and specific regional conditions, the effects of PV systems on the local environment, and the need for distributional justice. Large-scale plants are locally less accepted than smaller ones and there is a more open attitude towards the expansion of APV than of GM-PV on agricultural land. However, a range of concerns regarding consequences for landscape and biodiversity persists, and further research and clarification is required to address these issues.

Conclusions
We conclude that basic ecological standards and the demands of local stakeholders and interest groups should be taken into account when planning, implementing and reviewing PV projects in the future.
Neutrophil-to-lymphocyte ratio associated with symptomatic saccular unruptured intracranial aneurysm
Authors: Zheng De-Xiang , Lv Yi-Yang , Zhang Xiao-Jing , Ye Jie-Shun , Zhang Jian-Xing , Chen Cha , Luo Bin , Yan Dan 
Published: January 2024

Abstract
Background and purpose
Whether symptomatic unruptured intracranial aneurysms (UIAs) lead to change in circulating inflammation remains unclear. This study aims to evaluate the role of hematological inflammatory indicators in predicting symptomatic UIA.

Methods
Adult patients diagnosed with saccular intracranial aneurysm from March 2019 to September 2023 were recruited retrospectively. Clinical and laboratory data, including the white blood cells (WBC), neutral counts (NEUT), lymphocyte counts (LYM), and monocyte counts (MONO) of each patient, were collected. The neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were calculated as NLR = NEUT/LYM, LMR = LYM/MONO, SII = PLT*NEUT/LYM. The hematological inflammatory indicators were compared in symptomatic saccular and asymptomatic UIA patients. Multivariable logistic regression analyses were performed to explore the factors predicting symptomatic UIA.

Results
One hundred and fifty UIA patients with a mean age of 58.5 ± 12.4 were included, of which 68% were females. The NLR and LMR were significantly associated with symptomatic UIA, and the association remained in small UIAs (< 7 mm). The multiple logistic regression analysis showed that NLR was independently associated with symptomatic UIA. On ROC curve analysis, the optimal cutoff value of NLR to differentiate symptomatic from asymptomatic was 2.38. In addition, LMR was significantly associated with symptomatic UIA smaller than 7 mm.

Conclusion
There was a significant correlation between NLR and symptomatic UIA. The NLR was independently associated with symptomatic UIA.
Effect of Buteyko breathing technique on clinical and functional parameters in adult patients with asthma: a randomized, controlled study
Authors: Vagedes Katrin , Kuderer Silja , Ehmann Rainer , Kohl Matthias , Wildhaber Johannes , Jörres Rudolf A. , Vagedes Jan 
Published: January 2024

Abstract
Background
The established therapy of asthma might be supported by additional non-pharmaceutical measures, such as the Buteyko breathing technique (BBT); however, the available data are mixed. To clarify the effects of BBT in patients with asthma, we investigated whether it led to clinical improvements with correlation to functional parameters.

Methods
Using a randomized, controlled design, we studied two groups (n = 30 each) of patients with asthma under either BBT or usual therapy (UT) w/o BBT over a period of 3 months. The primary outcome comprised the voluntary control pause (CP) after 3 months, secondary outcomes an additional breathhold parameter, forced expiratory volume in 1 s (FEV1), capnovolumetry, exhaled nitric oxide (FeNO), Asthma Control Questionnaire (ACQ) and Nijmegen Questionnaire (NQ), and the use of medication (β2-agonists; inhaled corticosteroids, ICS).

Results
CP showed significant time-by-group interaction [F(1,58.09) = 28.70, p < 0.001] as well as main effects for study group [F(1,58.27) = 5.91, p = 0.018] and time [F(1,58.36) = 17.67, p < 0.001]. ACQ and NQ scores were significantly (p < 0.05 each) improved with BBT. This was associated with reductions in the use of β2-agonists and ICS (p < 0.05 each) by about 20% each. None of these effects occurred in the UT group. While FEV1 and the slopes of the capnovolumetric expiratory phases 2 and 3 did not significantly change, the capnovolumetric threshold volume at tidal breathing increased (p < 0.05) with BBT by about 10 mL or 10%, compared to baseline, suggesting a larger volume of the central airways. No significant changes were seen for FeNO.

Conclusions
BBT was clinically effective, as indicated by the fact that the improvement in symptom scores and the small increase in bronchial volume occurred despite the significant reduction of respiratory pharmacotherapy. As the self-controlled Buteyko breathing therapy was well-accepted by the participants, it could be considered as supporting tool in asthma therapy being worth of wider attention in clinical practice.
Trial registration Retrospectively registered on 10 March 2017 at ClinicalTrials.gov (NCT03098849).
Pandemic fatigue and depressive symptoms among college students in the COVID-19 context: indirect effects through sense of control and intolerance of uncertainty
Authors: Wu Qinglu , Zhang Tian-Ming , Wang Xue , Zhang Yan 
Published: January 2024

AbstractPandemic fatigue, the state of weariness, exhaustion, and demotivation to engage in protective behaviors during the coronavirus disease 2019 (COVID-19) pandemic, have been linked with depressive symptoms. However, the mechanism underlying this association remains unclear. Based on the stress process model, the present study examined the indirect effects of pandemic fatigue on depressive symptoms through the indirect roles of sense of control and intolerance of uncertainty. Data were collected from 1,162 Chinese undergraduate and postgraduate students (Mage = 21.61 years old, SD = 2.81, 64.29% women) through electronic questionnaires. The pandemic fatigue scale, the personal mastery scale, the short version of the Intolerance of Uncertainty Scale, and the Depression subscale of the Depression-Anxiety-Stress Scales were employed. Indirect effects were analyzed using structural equation modeling. The results revealed that pandemic fatigue related to COVID-19 was positively associated with depressive symptoms through (a) sense of control; (b) intolerance of uncertainty; and (c) a sequential pathway from sense of control to intolerance of uncertainty. The findings expand the application of the stress process model to the context of COVID-19 and deepen the understanding of pandemic fatigue—depressive symptoms link with considering the indirect roles of sense of control and intolerance of uncertainty. Psychological distress in the context of COVID-19 could be alleviated by the interventions on strengthening sense of control and tolerance of uncertainty and lessening the adverse effects of pandemic fatigue.
Does the carbon emission trading pilot policy promote green innovation cooperation? Evidence from a quasi-natural experiment in China
Authors: Xiaobao Peng , Jian Wu , Yuhui Chen , Ali Sumran , Qijun Xie 
Published: January 2024

AbstractGreen and low carbon transition is a broad and profound economic and social systematic change. Green innovation is a critical way to promote energy saving and emission reduction. Has China continuously promoted a carbon emission trading policy to significantly promote green innovation cooperation? Taking the implementation of the carbon emission trading pilot policy as a “quasi-natural experiment,” this study answers this question by exploring the impact of the policy on green innovation cooperation. Based on data on 274 cities from 2008 to 2020, the multi-time difference-in-differences model is used to evaluate the impact of the policy on green innovation cooperation. The results reveal that the carbon emission trading pilot policy significantly improved inter- and intra-city green innovation cooperation through the upgrading effect of industrial structure and the coverage effect of digital finance compared with the non-pilot cities at the city level. In addition, there are significant differences in the policy effects among cities with different degrees of openness to the outside world and command-and-control environmental regulation.
How simulated patients contribute to student learning in an authentic way, an interview study
Authors: Lovink Annelies , Groenier Marleen , van der Niet Anneke , Miedema Heleen , Rethans Jan-Joost 
Published: January 2024

Abstract
Introduction
Simulated patients (SPs) play an instrumental role in teaching communication skills and enhancing learning outcomes. Prior research mostly focused on the SP’s contribution to students’ learning outcomes by providing feedback afterwards. A detailed understanding of the contribution of the SP during SP-student encounters is currently lacking although the majority of the interaction between SPs and students occurs during the SP-student encounter. Therefore, this study focuses on how SPs see their contribution to meaningful student learning experiences during SP-student encounters.

Methods
We interviewed fifteen simulated patients from one institution. We explored their perspectives on meaningful learning experiences during SP-student encounters through in-depth, semi-structured interviews and analyzed using thematic analysis.

Results
SPs view their contribution to meaningful student learning during SP-student encounters from two perspectives. A collective perspective as a member of the community of SPs and an individual perspective. From the collective perspective, SPs believe that the fact that students deal with multiple varied SP-student encounters over time is of value for meaningful learning. From the individual perspective, we noticed that SPs think, act, and react from three different positions. First, as the patient in the role description, second, as a teaching aid and third, as an individual with personal experiences, beliefs, and values. SPs mentioned that the ratio between these different positions can vary within and between encounters.

Conclusions
According to SPs, we should value the variation between SPs, thereby creating meaningful variation in authentic interactions in SP-student encounters. SPs should be allowed to act and react from different positions during SP-student encounters, including their role description, as teaching aid, and based on their own experiences. In this way, SP-student encounters are optimized to contribute to meaningful student learning through authenticity.
Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review
Authors: Migliorini Filippo , Maffulli Nicola , Schäfer Luise , Simeone Francesco , Bell Andreas , Hofmann Ulf Krister 
Published: January 2024

Abstract
Background
The present systematic review investigated the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) of several frequent and established PROMs used to assess patients who have undergone TKA. This study was conducted according to the 2020 PRISMA statement.

Methods
In September 2023, PubMed, Web of Science, and Embase were accessed with no time constraint All clinical studies investigating tools to assess the clinical relevance of PROMs used to evaluate patients having received TKA were accessed. Only studies which evaluated the MCID, PASS, or SCB were eligible. The PROMs of interest were the Forgotten Joint Score-12 (FJS-12), the Oxford Knee Score (OKS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and its related subscales activity of daily living (ADL), pain, quality of life (QoL), sports and recreational activities, and symptoms, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score, the Knee Society Score (KSS) and related function score, and the Short Form-12 (SF-12) and Short Form-36 (SF-36).

Results
Data from 29,737 patients were collected. The overall risk of bias was low to moderate. The great variability of thresholds for MCID, SCB and PASS between questionnaires but also between investigated aspects was noted, whereby MCIDs for the SF-36 appear lower than for knee-specific questionnaires.

Conclusion
Despite its critical role from a patient’s perspective, the dimension of SCB is still neglected in the literature. Moreover, thresholds for the different concepts need to be condition-specific. We encourage authors to specifically report such data in future studies and to adhere to previously reported definitions to allow future comparison.
Level of evidence Level IV, systematic review and meta-analysis
Systemic sarcoidosis and primitive Gougerot-Sjörgen syndrome: a rare, complex yet intriguing association
Authors: Ikrou H. , Elkadah F. , Serhane H. 
Published: January 2024

AbstractPrimary Sjogren’s syndrome is a chronic autoimmune disease affecting mainly the exocrine glands, typically presenting with sicca syndrome, but systemic multi-organ manifestations are possible. The diagnosis is based on the 2016 ACR-EULAR criteria. On the other hand, sarcoidosis, which is also a chronic systemic disease, is characterized by tissue infiltration with noncaseating granulomas. The granulomas may occur in any organ, but the most frequently affected sites are the lungs, lymph nodes, skin, eyes, and liver. Traditionally, sarcoidosis is considered to be an exclusion criterion for the diagnosis of primary Sjogren’s syndrome, mainly because of overlapping clinical features.We report the case of a 60-year-old female patient of North African descent, hospitalized initially for chronic dyspnea associated with other systemic manifestations such as sicca syndrome, and in whom we have objectified biological and histological features of both systemic sarcoidosis and systemic primitive Sjogren’s syndrome at the same time.The coexistence of sarcoidosis and Sjogren’s syndrome is not frequent and has been rarely reported. We aim to bring more attention to the possibility of an association of these two systemic diseases despite what is typically recommended. Subsequently, it might be of interest to remove sarcoidosis from the elimination criteria in order to avoid the possibility of misdiagnosis.
Understanding the Termination of Urologic Cancer Clinical Trials: Insights and Challenges
Authors: Alhajahjeh Abdulrahman , Hmeidan Majedah , Elatrsh Mus'ab , Al-Abbadi Faris , Kakish Diala , Sukerji Razan , Salah Mohammad , Al Awamlh Bashir Al Hussein , Lee David I. , Shahait Mohammed 
Published: January 2024

PURPOSE Clinical trials are valuable evidence for managing urologic malignancies. Early termination of clinical trials is associated with a waste of resources and may substantially affect patient care. We sought to study the termination rate of urologic cancer clinical trials and identify factors associated with trial termination. METHODS A cross-sectional search of ClinicalTrials.gov identified completed and terminated kidney, prostate, and bladder cancer clinical trials started. Trials were assessed for reasons for termination. Multivariable analyses were conducted to determine the significant factors associated with the termination. RESULTS Between 2000 and 2020, 9,145 oncology clinical trials were conducted, of which 11.30% (n = 1,033) were urologic cancer clinical trials. Of the urologic cancer clinical trials, 25.38% (n = 265) were terminated, with low patient accrual being the most common reason for termination, 52.9% (n = 127). Multivariable analysis showed that only the university funding source odds ratio (OR) of 2.20 (95% CI, 1.45 to 3.32), single-center studies OR of 2.11 (95% CI, 1.59 to 2.81), and sample size of <50 were significant predictors of clinical trial termination OR of 5.26 (95% CI, 3.85 to 7.69); all P values are <.001. CONCLUSION The termination rate of urologic cancer clinical trials was 25%, with low accrual being the most frequently reported reason. Trials funded by a university, single-center trials, and small trials (sample size <50) were associated with early termination. A better understanding of these factors might help researchers, funding agencies, and other stakeholders prioritize resource allocations for multicenter trials that aim to recruit a sufficient number of patients.
Validity and Efficiency of Progression-Free Survival-2 as a Surrogate End Point for Overall Survival in Advanced Cancer Randomized Trials
Authors: Woodford Rachel , Zhou Deborah , Kok Peey-Sei , Lord Sally J. , Friedlander Michael , Marschner Ian , Simes R. John , Lee Chee Khoon 
Published: January 2024

PURPOSE Progression-free survival (PFS)-2, defined as the time from randomization to progression on second-line therapy, is potentially a more reliable surrogate than PFS for overall survival (OS), but will require longer follow-up and a larger sample size. We sought to compare the validity and efficiency, defined as proportional increase in follow-up time and sample size, of PFS-2 to PFS. METHODS We performed an electronic search to identify randomized trials of advanced solid tumors reporting PFS, PFS-2, and OS as prespecified end points. Only studies that had protocols that defined measurement of PFS-2 and follow-up for patients after first disease progression were included. We compared correlations in the relative treatment effect for OS with PFS and PFS-2. We reconstructed individual patient data from survival curves to estimate time to statistical significance (TSS) of the relative treatment effect. We further computed the sample size (person-year [PY] follow-up) required to reach statistical significance. RESULTS Across the 42 analysis units and 21,255 patients, the correlation of the relative treatment effect between OS and PFS-2, r, was 0.70 (95% CI, 0.41 to 0.80) and r = 0.46 (95% CI, 0.26 to 0.74) for OS and PFS. The median differences in TSS between OS with PFS, OS with PFS-2, and PFS with PFS-2 were 16.59 (95% CI, 4.48 to not reached [NR]), 10.0 (95% CI, 2.2 to NR), and 4.31 (95% CI, 2.92 to 13.13) months, respectively. The median difference in PYs required to reach statistical significance for PFS-2 over PFS was 156 (95% CI, 82 to 500) PYs, equivalent to an estimated median 12.7% increase in PYs. CONCLUSION PFS-2 offers improved correlation with OS than PFS with a modest increase in follow-up time and sample size. PFS-2 should be considered as a primary end point in future trials of advanced cancers.