bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Frontal Cortical Thickness and Externalizing Psychopathology is Associated with Treatment Outcomes in Children with Externalizing Problems: A Preliminary Pilot Study: La relation entre l’épaisseur du cortex frontal et les troubles extériorisés est associée aux résultats thérapeutiques chez les enfants ayant des problèmes extériorisés : une étude pilote préliminaire
Authors: Propp Lee , Nakua Hajer , Bedard Anne-Claude V. , Sanches Marcos , Ameis Stephanie H. , Andrade Brendan F. 
Published: February 2025

Objectives Children with externalizing disorders commonly show emotion dysregulation and callous–unemotional (CU) traits. However, it is unclear whether emotion dysregulation and CU traits share underlying neurobiology that can be predictive of psychosocial treatment outcomes. In this preliminary study, we examined neural correlates of externalizing psychopathology dimensions and their prediction of treatment outcomes. Methods We analyzed a pilot sample of 17 children with an externalizing disorder (9–12 years; 10.45 ± 1.02) who underwent structural magnetic resonance imaging (MRI) before participating in a 15-week psychosocial group intervention targeting conduct problems. We examined cross-sectional associations between emotion dysregulation or CU traits and cortical thickness (anterior cingulate cortex [ACC] and insula) and amygdala volume at baseline. We then examined whether the pre-treatment brain–behaviour relationships were linked to reduction in conduct problems post-treatment. Results Lower ACC and insula thickness as well as amygdala volume was associated with greater levels of emotion dysregulation and CU traits at baseline (pre-treatment, r = |0.36–0.61|). There was a significant three-way interaction between emotion dysregulation/CU traits, left insula/right rostral ACC, and treatment (pre/post; β = −1.01 to 3.6). Overall, greater baseline insular and rostral ACC thickness was related to reductions in conduct problems following group-based psychosocial intervention regardless of baseline emotion dysregulation and CU trait levels. Conclusions The results provide preliminary evidence of shared neural signatures underlying both emotion dysregulation and CU traits. Additionally, alterations in frontolimbic brain structure may be useful predictors of pre-treatment associations with externalizing psychopathology dimensions and post-treatment behavioural outcomes.
The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d’aide, et dévoilement des actes d’automutilation et de la suicidalité chez les adolescents : étude représentative de la population
Authors: Hammond Nicole G. , Gravel Christopher , Ferro Mark A. , Landry Hannah , Geoffroy Marie-Claude , Racine Nicole , Colman Ian 
Published: February 2025

Background Few studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking. Methods We identified youths, 14–17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios. Results A total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models. Conclusion We found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.
The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure
Authors: Hill Harry , Rawdin Andrew , Wailoo Allan , Briggs Victoria , Lambie Mark , McCullough Keith , Dunn Louese , Davies Simon , Wilkie Martin , Fotheringham James 
Published: February 2025

Background High-quality and timely peritoneal access is essential for effective peritoneal dialysis (PD). Existing comparisons of medical compared to surgical catheter insertion have focused on the incidence of catheter events, but the cost-effectiveness of providing medical in addition to surgical catheter insertion in a dual pathway, compared to providing surgical insertion alone has not been evaluated. Methods Data from the UK Catheter study, exploring how patient, service and insertion technique factors interact was used to estimate the comparative rates of catheter events between medical and surgical catheter insertion. A cost-effectiveness model estimates the health benefits and costs of providing medical in addition to surgical catheter insertion, compared to surgical insertion alone. Parametric modelling estimated time to catheter events, haemodialysis and transplantation to populate the model. Results Data on 769 first catheter insertions informs the model (325 medical and 444 surgical). Fewer catheter events were observed with medical insertion. The dual insertion pathway (69% medical, 31% surgical) was therefore associated with lower lifetime catheter events (3.18 vs. 3.34) and longer time on PD (3.07 vs. 3.00 years) than a purely surgical insertion pathway. The lifetime mean differences in quality-adjusted life years (7.12 vs. 7.00) and near identical costs (£226,549 vs. £226,764) meant dual insertion pathway was likely to be cost-effective, a finding robust to a series of sensitivity analyses. Conclusion Offering medical in addition to surgical catheter insertion techniques has the potential to improve clinical outcomes and is likely to be highly cost-effective compared to surgical insertion alone.
Examining employment outcomes of deaf and hard-of-hearing people in The Netherlands using non-public microdata
Authors: Elsendoorn Bas C.H.M. , Wauters Loes , Tijsseling Corrie , van Klaveren Chris P.B.J. , Cornelisz Ilja , Heppe Eline C.M. 
Published: February 2025

Background It is internationally recognized that people with disabilities have an equal right to work as people without disabilities. This includes deaf and hard-of-hearing (DHH) people. Previous studies, primarily conducted in the US, showed discrepancies between employment outcomes of DHH people and typically hearing people. Objective There is still a lack of knowledge about the current employment status of DHH people in the Netherlands. Furthermore, additional job characteristics such as income sources and sectors of employment are yet to be examined. This paper aims to address this lack of knowledge. Methods This study used non-public microdata to examine employment outcomes of DHH people who claimed sensory disability care in the Netherlands between 2015 and 2019 ( n = 5609) and compare them to a matched Dutch population (MDP) ( n = 5609). Results Despite small differences in employment participation, DHH claimants are more likely to have an income from sick leave/disability pension, other social benefits, and retirement compared to the MDP. DHH claimants also have lower average hourly wages, work fewer hours per week, work in different employment sectors, and stay in their first job longer compared to the MDP. Conclusions The results of this study show that there are labor force differences between DHH claimants and the MDP. Further steps must be taken to identify the causes of these differences and develop policies and interventions to address these when deemed necessary.
Prevalence of HPV in a Peruvian Healthcare Network: A Descriptive Cross-Sectional Study
Authors: Araujo Jhajaira M. , Ramon-Cotrina Maria , Quispe-Martinez Rosa , Rios-Rios Mayra , Quispe-Gonzaga Maribel , Saldaña-Reyes Carlos O. , Medina Paula , Cornejo Melanie , Pinto Joseph A. , Dyer Richard 
Published: February 2025

Introduction Human papillomavirus (HPV) infection is a common sexually transmitted infection often associated with cancer development. This study aimed to estimate the prevalence of HPV in women receiving care at the AUNA healthcare network in Peru. Methods We conducted an observational, descriptive, cross-sectional, retrospective study. A de-identified database of HPV-positive women who underwent the BD Onclarity™ HPV Assay between December 2018 and December 2021 at Auna clinics was analyzed. The database contained information regarding age, city, and HPV type. High-risk HPV types were analyzed individually (16, 18, 31, 45, 51, 52) and pooled [P1 (33, 58), P2 (56,59,66), and P3 (35,39,68)]. The study was approved by an independent research ethics committee in Peru. Results Of 68,714 women included in the study, the HPV prevalence was 14.21% (N = 9765, 95%CI:13.95%–14.47%). The highest prevalence was detected in Piura (16.85%, 95%CI:15.40%–18.38%), where HPV-51, HPV-52, HPV-P1, HPV-P2, and HPV-P3 were most common compared to other Peruvian cities included in the study. In Arequipa, the prevalence was the lowest (13.58%, 95%CI:12.38%–14.85%), but the percentage prevalence of HPV-16 was the highest compared to other cities. The prevalence of multiple HPV infections was 2.88% (N = 1981, 95%CI:2.76%–3.01%), with most of them co-presenting two types of HPV (N = 1522). The most frequent co-occurrences were P2 and P3, P2 and 52, and P2 and 16. Among HPV-positive women, the mean age was 41.31 years (±9.48) and 25.29% were in the 31–35 years group. HPV-P2 was the most frequent in all age groups except in the 65–72 years group, where HPV-P3 was the most common. Conclusion HPV prevalence was shown to be highest in Piura, with the most prevalent types being HPV-16, HPV-52, and HPV-P2 (HPV-56, -59, -66). HPV infection was found to be more frequent among women in the 31–35 years age group.
Descriptive analysis of the efficacity of R-GEMOX /R-IE/R-CEPP in patients with relapsed/refractory (R/R) transplant-ineligible diffuse large B-cell lymphoma (DLBCL)
Authors: Fulbert Baptiste , Vincent Théo , Clarenne Justine , Abdelouahab Imman , Bozec Antoine Le , Durot Eric , Slimano Florian 
Published: February 2025

Background Patients with Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL) ineligible for Hematopoietic Stem Cell Transplantation (HSCT) may benefit from a second line anticancer drug regimen but real-life outcomes are lacking. Objective To describe the efficacity of 3 anticancer drug regimens (Gemcitabine and Oxaliplatin GEMOX; Ifosfamide and Etoposide IE; Cyclophosphamide, Etoposide, Procarbazine and Prednisone CEPP) combined with Rituximab (R-) in terms of progression-free (PFS) and overall survival (OS). Patients Retrospective study including R/R DLBCL patients HSCT ineligible who received at least one cycle of R-GEMOX, R-IE or R-CEPP between 2010 and 2022. Demographic, clinical, biological and survival data were collected. Univariate and multivariate analysis were performed to identify associated variables with survival outcomes. Results Sixty-two patients (median age 78 [40–102] with predominantly stage III-IV DLBCL (n = 49, 79%), non-germinal center-B like (n = 27, 44%) were included. Median OS and PFS were 9 (CI95% [3–10]) and 4 months (CI95% [2–13]) for R-GEMOX, 4 (CI95% [2–6]) and 1 month (CI95% [1–4]) for R-IE and 5 (CI95% [3–6]) and 3 months (CI95% [2–15]) for R-CEPP, respectively. Univariate analysis selects ECOG, aa-IPI scores, LDH rate and Ann-Arbor stage with no independently association in multivariate analysis. Conclusion All three regimens show modest survival benefit especially between last anticancer treatment course and death. Emergence of bispecific antibodies and Cart-cells for which real-life benefits have yet to be demonstrated could be coupled with improved access to early palliative care.
End-of-life symptoms and polypharmacy in lung and other cancer patients receiving palliative care in Turkey
Authors: Kocatepe Vildan , Uludağ Kızıltepe Halide Fulya , Yildirim Dilek , Oruç Özlem 
Published: February 2025

Introduction Patients diagnosed with cancer are often prescribed a wide range of medicines. In this study, it was aimed at examining the end-of-life symptoms and polypharmacy status of patients hospitalized in the palliative care unit with the diagnosis of lung cancer and other cancers. Methods The data for the retrospective-descriptive study were obtained from hospital records and an automation system. The sample of the study included the data of all patients (n = 201) who were hospitalized in the palliative care unit between 2016–2021 in Turkey. Results The most common symptoms of end-of-life patients were dyspnea (85.1%) and pain (67.7%). The mean number of medications used by the patients on the day of death was 10.89 ± 3.16, it was 12.50 ± 3.11 on the third day before death, 13.24 ± 3.07 on the 6th day before death, 13.50 ± 3.03 on the 9th day before death. There was a statistically significant difference between the mean number of medications used by the patients according to the presence of dyspnea on the day of death (t = 1.997; p = .047) and pain on the day of death (t = 3.781; p = .001). There was a statistically significant difference between the mean number of medications used by the patients according to the presence of pain on the sixth day before death (t = 2.613; p = .010) and the ninth day before death (t = 2.940; p = .004). Conclusion The number of medications used by the patients decreased from the 9th day before death to the day of death and their polypharmacy status continued.
Co-creating research at The AI, media, and democracy lab: Reflections on the role of academia in collaborations with media partners
Authors: Cools Hannes , Helberger Natali , de Vreese Claes 
Published: February 2025

This commentary explores academia’s role in co-creating research with media partners, focusing on the distinct roles and challenges that each stakeholder brings to such partnerships. Starting from the perspective of the AI, Media, and Democracy Lab, and building on the Ethical, Legal, and Societal Aspects (ELSA) approach, we share key learnings from 3 years of collaborations with (media) partners. We conclude that navigating dual roles, expectations, output alignment, and a process of knowledge sharing are important requirements for academics and (media) partners to adequately co-create research and insights. We also argue that these key lessons do not always square with how academic research is organized and funded. We underscore that changes in funding structures and the way academic research is assessed can further facilitate the co-creation of research between academic research and projects in the media sector.
Endovascular Aortic Aneurysm Repair for Abdominal Aortic Aneurysm With Type V Horseshoe Kidney
Authors: Wu Mingwei , Xiong Jiang 
Published: February 2025

Purpose: Abdominal aortic aneurysm (AAA) with concomitant Horseshoe kidney (HSK) is rare. When open surgery is not feasible, preserving the renal isthmus artery (RIA) during endovascular treatment presents a challenge. Case report: A 70-year-old male presented with a 57.8 mm × 54.3 mm AAA and type V HSK perfused by a 4.4 mm RIA from the inferior mesenteric artery and a 4.6 mm RIA from the aortic bifurcation. This case report describes an endovascular aortic aneurysm repair (EVAR) performed on an AAA coexisting with a type V HSK. One-year follow-up: the AAA had regressed, and the HSK remained perfused without any endoleak or increase in serum creatinine levels. Conclusion: The utilization of EVAR offers a feasible option for AAA combined with type V HSK, particularly in cases of high surgical risk. Clinical Impact In Abdominal aortic aneurysm (AAA) with type V horseshoe kidney (HSK), preserving renal isthmus arteries (RIAs) is critical when they provide a substantial portion of the HSK blood supply.When open surgery is not feasible, preserving the RIA during endovascular treatment presents a challenge.The use of EVAR, incorporating a periscope stent and embolization, provides a viable treatment option for patients with AAA and type V HSK, especially in high surgical risk cases.
Risk of postoperative bleeding and thromboembolic events in anticoagulated patients undergoing transurethral resection of bladder tumors
Authors: Scherer Thomas Paul , Dam Cici , Bieri Uwe , Eberli Daniel , Strebel Raeto 
Published: February 2025

Background: Transurethral resection of the bladder (TURB) harbors a high-risk for postoperative bleeding, especially in patients requiring anticoagulation. Recently, direct oral anticoagulants (DOACs) have become a popular alternative to vitamin K antagonists (VKAs), though their impact on TURB complications remains unclear. Objectives: To assess the postoperative complications of TURB from patients taking DOACs and VKAs. Design: Retrospective cohort study. Materials and methods: We retrospectively identified anticoagulated patients undergoing a TURB at our institution between 2012 and 2022 and divided them into two groups: whether they received VKA or DOAC. Follow-up of each patient was performed for 3 months. Occurrence and time to event of postoperative bleeding and thromboembolic events were recorded. A multivariable regression analysis was performed to assess risk differences. Results: A total of 167 patients (11.7%) fulfilled the inclusion criteria, of which 102 patients (61.1%) received a DOAC and 65 patients (38.9%) a VKA. Postoperative bleeding led to re-catheterization in 13 (12.8%) DOAC and 6 (9.2%) VKA patients ( p = 0.49) and re-intervention in 7 (6.9%) DOAC and 4 (6.2%) VKA patients ( p = 0.86). Blood transfusions were administered to 3 DOAC patients (2.9%), none in the VKA group. No thromboembolic events were reported. Conclusion: TURB carries low morbidity in anticoagulated patients. Thromboembolic events and the need for blood transfusion are infrequent. No substantial difference between the postoperative bleeding risk of patients receiving DOAC or VKA was found. All bleeding complications occurred within 2 weeks, marking it a potentially safe point in time to restart the OAC thereafter.
Performance of Three Continuous Glucose Monitoring Systems in Adults With Type 1 Diabetes
Authors: Eichenlaub Manuel , Waldenmaier Delia , Wehrstedt Stephanie , Pleus Stefan , Link Manuela , Jendrike Nina , Öter Sükrü , Haug Cornelia , Schinz Maren , Braunack-Mayer Vincent , Schneider Regula , Brandt Derek , Freckmann Guido 
Published: February 2025

Background: The performance of continuous glucose monitoring (CGM) systems is difficult to compare due to different study designs and a lack of head-to-head studies. This study evaluated the performance of FreeStyle Libre 3 (FL3), Dexcom G7 (DG7), and Medtronic Simplera (MSP) against different comparator methods and during clinically relevant glycemic scenarios. Method: Twenty-four adult participants with type 1 diabetes mellitus wore one sensor of each CGM system in parallel for up to 15 days. Sensors of DG7 and MSP were exchanged on days 5 and 8, respectively. Three 7-hour sessions with 15-minute comparator blood glucose–level measurements using YSI 2300 (YSI, venous), Cobas Integra (INT, venous), and Contour Next (CNX, capillary) were conducted on days 2, 5, and 15. Simultaneously, glucose-level excursions with transient hyperglycemia and hypoglycemia were induced according to a recently published testing procedure. The accuracy was evaluated using various metrics, including mean absolute relative differences (MARDs). Results: Compared with YSI data, the MARDs of FL3, DG7, and MSP were 11.6%, 12.0%, and 11.6%, respectively. Relative to the INT data, the corresponding MARDs were 9.5%, 9.9%, and 13.9%, respectively, and compared with CNX data, MARDs were 9.7%, 10.1%, and 16.6%, respectively. Both FL3 and DG7 showed better accuracy in the normoglycemic and hyperglycemic range, while MSP performed better in the hypoglycemic range. Conclusions: Performance results of all CGM systems varied depending on the comparator method. However, across comparators FL3 and DG7 tended to be more accurate compared with MSP. All CGM systems showed a lower accuracy compared with previous studies, emphasizing the need for comprehensive study design guidelines.
Effect of selective suture removal on graft astigmatism after corneal transplantation in keratoconus
Authors: Feizi Sepehr , Javadi Mohammad Ali , Karjou Zahra , Nouri Nasim , Oraeeyazdani Maryam , Khorrami Zahra , Esfandiari Hamed 
Published: February 2025

Background: Selective suture removal has been demonstrated to be effective in reducing post-keratoplasty astigmatism, while the remaining sutures are left in place. Existing studies typically focus on outcomes immediately after selective suture removal, without delving into the final suture-out keratometric astigmatism. Objectives: To examine the impact of selective suture removal on corneal graft astigmatism following keratoplasty in keratoconus and identify potential factors associated with the changes in graft astigmatism after suture removal. Design: Retrospective, comparative interventional case series. Methods: The study included 118 consecutive eyes of 118 cases that underwent corneal transplantation for keratoconus and had a keratometric astigmatism of ⩾4 D. One or two interrupted sutures corresponding to the steep meridian were removed per session. Patients were re-evaluated at 1 to 2-month intervals, repeating the procedure until achieving a keratometric astigmatism of <4.0 D or no interrupted sutures remained in the steep meridian. Results: The mean recipient age was 28.4 ± 8.4 years. A total of 234 selective suture removals were performed, with a mean of 2.0 ± 1.1 removals per eye. Pre-suture removal keratometric astigmatism significantly decreased from 6.3 ± 2.0 D to 3.91 ± 2.23 D after the completion of selective suture removal ( p < 0.001). This value was significantly increased to 5.45 ± 2.93 D after all suture removal ( p < 0.001). Higher pre-suture removal astigmatism and deep anterior lamellar keratoplasty were associated with a more favorable response to selective suture removal. Conclusion: Selective suture removal effectively modifies graft curvature to reduce post-keratoplasty astigmatism in keratoconus patients. However, its efficacy markedly diminishes after all sutures are removed. This procedure is particularly effective in patients with higher pre-suture removal astigmatism and those undergoing deep anterior lamellar keratoplasty.