bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic evaluation of the sustainability of the Spanish primary sector within the framework of the circular economy
Authors: Castillo‐Díaz Francisco José , Belmonte‐Ureña Luis J. , Batlles‐delaFuente Ana , Camacho‐Ferre Francisco 
Published: November 2023

AbstractFood security depends on the implementation of sustainable development in agri‐food. It is essential to determine the sustainability of the main production systems in order to establish specific measures for each territory, by virtue of correcting their negative externalities and improving the commitment of stakeholders. Therefore, this article assessed the economic, social, environmental and global sustainability of the Spanish primary sector based on a synthetic indicator proposed in previous research. The results suggest the existence of a moderate degree of sustainability of the food production system in Spain (0.5019), with the regions of Aragón (0.5482), Castile and Leon (0.5473), Extremadura (0.5438) and Andalucía (0.5399) standing out. An inverse relationship between the economic and the environmental subcomponents of sustainability was obtained. The cluster analysis revealed the need to apply a customized territorial policy in order to meet sustainability goals due to the diversity of agricultural subsectors identified in them.
Dressing Paraffin Wax/Boron Nitride Phase Change Composite with a Polyethylene “Underwear” for the Reliable Battery Safety Management
Authors: Zhang Yongzheng , Xie Keqing , Shi Jiawei , Guo Cong , Lin Cheng‐Te , Che Jianfei , Wu Kai 
Published: November 2023

AbstractPhase change material (PCM) can provide a battery system with a buffer platform to respond to thermal failure problems. However, current PCMs through compositing inorganics still suffer from insufficient thermal‐transport behavior and safety reliability against external force. Herein, a best‐of‐both‐worlds method is reported to allow the PCM out of this predicament. It is conducted by combining a traditional PCM (i.e., paraffin wax/boron nitride) with a spirally weaved polyethylene fiber fabric, just like the traditional PCM is wearing functional underwear. On the one hand, the spirally continuous thermal pathways of polyethylene fibers in the fabric collaborate with the boron nitride network in the PCM, enhancing the through‐plane and in‐plane thermal conductivity to 10.05 and 7.92 W m−1 K, respectively. On the other, strong polyethylene fibers allow the PCM to withstand a high puncture strength of 47.13 N and tensile strength of 18.45 MPa although above the phase transition temperature. After this typical PCM packs a triple Li‐ion battery system, the battery can be promised reliable safety management against both thermal and mechanical abuse. An obvious temperature drop of >10 °C is observed in the battery electrode during the cycling charging and discharging process.
Activating the MnS0.5Se0.5 Microspheres as High‐Performance Cathode Materials for Aqueous Zinc‐Ion Batteries: Insight into In Situ Electrooxidation Behavior and Energy Storage Mechanisms
Authors: Guo Chenchen , Zhou Ruyi , Liu Xinru , Tang Ruiying , Xi Wenxin , Zhu Yirong 
Published: November 2023

AbstractManganese‐based materials are regarded as the most prospective cathode materials because of their high natural abundance, low toxicity, and high specific capacity. Nevertheless, the low conductivity, poor cycling performance, and controversial energy storage mechanisms hinder their practical application. Here, the MnS0.5Se0.5 microspheres are synthesized by a two‐step hydrothermal approach and employed as cathode materials for aqueous zinc‐ion batteries (AZIBs) for the first time. Interestingly, in‐depth ex situ tests and electrochemical kinetic analyses reveal that MnS0.5Se0.5 is first irreversibly converted into low‐crystallinity ZnMnO3 and MnOx by in situ electrooxidation (MnS0.5Se0.5‐EOP) during the first charging process, and then a reversible co‐insertion/extraction of H+/Zn2+ occurs in the as‐obtained MnS0.5Se0.5‐EOP electrode during the subsequent discharging and charging processes. Benefiting from the increased surface area, shortened ion transport path, and stable lamellar microsphere structure, the MnS0.5Se0.5‐EOP electrodes deliver high reversible capacity (272.8 mAh g−1 at 0.1 A g−1), excellent rate capability (91.8 mAh g−1 at 2 A g−1), and satisfactory cyclic stability (82.1% capacity retention after 500 cycles at 1 A g−1). This study not only provides a powerful impetus for developing new types of manganese‐based chalcogenides, but also puts forward a novel perspective for exploring the intrinsic mechanisms of in situ electrooxidation behavior.
Mn‐Anti‐CTLA4‐CREKA‐Sericin Nanotheragnostics for Enhanced Magnetic Resonance Imaging and Tumor Immunotherapy
Authors: Huang Zixuan , Wang Yejing , Su Can , Li Wanting , Wu Min , Li Wuling , Wu Jun , Xia Qingyou , He Huawei 
Published: November 2023

AbstractThe integration of magnetic resonance imaging (MRI), cGAS‐STING, and anti‐CTLA‐4 (aCTLA‐4) based immunotherapy offers new opportunities for tumor precision therapy. However, the precise delivery of aCTLA‐4 and manganese (Mn), an activator of cGAS, to tumors remains a major challenge for enhanced MRI and active immunotherapy. Herein, a theragnostic nanosphere Mn‐CREKA‐aCTLA‐4‐SS (MCCS) is prepared by covalently assembling Mn2+, silk sericin (SS), pentapeptide CREKA, and aCTLA‐4. MCCS are stable with an average size of 160 nm and is almost negatively charged or neutral at pH 5.5/7.4. T1‐weighted images showed MCCS actively targeted tumors to improve the relaxation rate r1 and contrast time of MRI. This studies demonstrated MCCS raises reactive oxygen species levels, activates the cGAS‐STING pathway, stimulates effectors CD8+ and CD80+ T cells, reduces regulatory T cell numbers, and increases IFN‐γ and granzyme secretion, thereby inducing tumor cells autophagy and apoptosis in vitro and in vivo. Also, MCCS are biocompatible and biosafe. These studies show the great potential of Mn‐/SS‐based integrative material MCCS for precision and personalized tumor nanotheragnostics.
Tumor Microenvironment‐Induced Drug Depository for Persistent Antitumor Chemotherapy and Immune Activation
Authors: Gao Fan , Xue Chun , Dong Jianhui , Lu Xinxin , Yang Nan , Ou Changjin , Mou Xiaozhou , Zhang Yi‐Zhou , Dong Xiaochen 
Published: November 2023

AbstractHerein, a drug‐loading nanosystem that can in situ form drug depository for persistent antitumor chemotherapy and immune regulation is designed and built. The system (DOX@MIL‐LOX@AL) is fabricated by packaging alginate on the surface of Doxorubicin (DOX) and lactate oxidase (LOX) loaded MIL‐101(Fe)‐NH2 nanoparticle, which can easily aggregate in the tumor microenvironment through the cross‐linking with intratumoral Ca2+. Benefiting from the tumor retention ability, the fast‐formed drug depository will continuously release DOX and Fe ions through the ATP‐triggered slow degradation, thus realizing persistent antitumor chemotherapy and immune regulation. Meanwhile, LOX in the non‐aggregated nanoparticles is able to convert the lactic acid to H2O2, which will be subsequently decomposed into ·OH by Fe ions to further enhance the DOX‐induced immunogenic death effect of tumor cells. Together, with the effective consumption of immunosuppressive lactic acid, long‐term chemotherapy, and oxidation therapy, DOX@MIL‐LOX@AL can execute high‐performance antitumor chemotherapy and immune activation with only one subcutaneous administration.
Rational Design of High‐Loading Electrodes with Superior Performances Toward Practical Application for Energy Storage Devices
Authors: Tang Bin , Wei Yike , Jia Rui , Zhang Fan , Tang Yongbing 
Published: November 2023

AbstractHigh‐loading electrodes play a crucial role in designing practical high‐energy batteries as they reduce the proportion of non‐active materials, such as current separators, collectors, and battery packaging components. This design approach not only enhances battery performance but also facilitates faster processing and assembly, ultimately leading to reduced production costs. Despite the existing strategies to improve rechargeable battery performance, which mainly focus on novel electrode materials and high‐performance electrolyte, most reported high electrochemical performances are achieved with low loading of active materials (<2 mg cm−2). Such low loading, however, fails to meet application requirements. Moreover, when attempting to scale up the loading of active materials, significant challenges are identified, including sluggish ion diffusion and electron conduction kinetics, volume expansion, high reaction barriers, and limitations associated with conventional electrode preparation processes. Unfortunately, these issues are often overlooked. In this review, the mechanisms responsible for the decay in the electrochemical performance of high‐loading electrodes are thoroughly discussed. Additionally, efficient solutions, such as doping and structural design, are summarized to address these challenges. Drawing from the current achievements, this review proposes future directions for development and identifies technological challenges that must be tackled to facilitate the commercialization of high‐energy‐density rechargeable batteries.
Zero‐Strain Na3V2(PO4)2F3@Rgo/CNT Composite as a Wide‐Temperature‐Tolerance Cathode for Na‐Ion Batteries with Ultrahigh‐Rate Performance
Authors: Shi Chenglong , Xu Junling , Tao Tao , Lu Xiaoyi , Liu Guoping , Xie Fuqiang , Wu Sheng , Wu Yanxue , Sun Zhipeng 
Published: November 2023

AbstractSodium‐ion batteries (SIBs) are widely considered a hopeful alternative to lithium‐ion battery technology. However, they still face challenges, such as low rate capability, unsatisfactory cycling stability, and inferior variable‐temperature performance. In this study, a hierarchical Na3V2(PO4)2F3 (NVPF) @reduced graphene oxide (rGO)/carbon nanotube (CNT) composite (NVPF@rGO/CNT) is successfully constructed. This composite features 0D Na3V2(PO4)2F3 nanoparticles are coated by a cross‐linked 3D conductive network composed of 2D rGO and 1D CNT. Furthermore, the intrinsic Na+ storage mechanism of NVPF@rGO/CNT through comprehensive characterizations is unveiled. The synthesized NVPF@rGO/CNT exhibits fast ionic/electronic transport and excellent structural stability within wide working temperatures (−40–50 °C), owing to the zero‐strain NVPF and the coated rGO/CNT conductive network that reduces diffusion distance for ions and electrons. Moreover, the stable integration between NVPF and rGO/CNT enables outstanding structural stability to alleviate strain and stress induced during the cycle. Additionally, a practice full cell is assembled employing a hard carbon anode paired with an NVPF@rGO/CNT cathode, which provides a decent capacity of 105.2 mAh g−1 at 0.2 C, thereby attaining an ideal energy density of 242.7 Wh kg−1. This work provides valuable insights into developing high‐energy and power‐density cathode materials for SIBs.
2D/2D Heterojunction of BiOBr/BiOI Nanosheets for In Situ H2O2 Production and Activation toward Efficient Photocatalytic Wastewater Treatment
Authors: Low Beverly Qian Ling , Jiang Wenbin , Yang Jing , Zhang Mingsheng , Wu Xiao , Zhu Hui , Zhu Houjuan , Heng Jerry Zhi Xiong , Tang Karen Yuanting , Wu Wen‐Ya , Cao Xun , Koh Xue Qi , Chai Casandra Hui Teng , Chan Chui Yu , Zhu Qiang , Bosman Michel , Zhang Yong‐Wei , Zhao Ming , Li Zibiao , Loh Xian Jun , Xiong Yujie , Ye Enyi 
Published: November 2023

AbstractThe presence of toxic organic pollutants in aquatic environments poses significant threats to human health and global ecosystems. Photocatalysis that enables in situ production and activation of H2O2 presents a promising approach for pollutant removal; however, the processes of H2O2 production and activation potentially compete for active sites and charge carriers on the photocatalyst surface, leading to limited catalytic performance. Herein, a hierarchical 2D/2D heterojunction nanosphere composed of ultrathin BiOBr and BiOI nanosheets (BiOBr/BiOI) is developed by a one‐pot microwave‐assisted synthesis to achieve in situ H2O2 production and activation for efficient photocatalytic wastewater treatment. Various experimental and characterization results reveal that the BiOBr/BiOI heterojunction facilitates efficient electron transfer from BiOBr to BiOI, enabling the one‐step two‐electron O2 reduction for H2O2 production. Moreover, the ultrathin BiOI provides abundant active sites for H2O2 adsorption, promoting in situ H2O2 activation for •O2− generation. As a result, the BiOBr/BiOI hybrid exhibits excellent activity for pollutant degradation with an apparent rate constant of 0.141 min−1, which is 3.8 and 47.3 times that of pristine BiOBr and BiOI, respectively. This work expands the range of the materials suitable for in situ H2O2 production and activation, paving the way toward sustainable environmental remediation using solar energy.
Non‐degenerate U‐statistics for data missing completely at random with application to testing independence
Authors: Aleksić Danijel , Cuparić Marija , Milošević Bojana 
Published: November 2023

SummaryAlthough the era of digitalization has enabled access to large quantities of data, due to their insufficient structuring, some data are often missing, and sometimes, the percentage of missing data is significant compared to the entire sample. On the other hand, most of the statistical methodology is designed for complete data. Here, we explore the asymptotic properties of non‐degenerate U‐statistics when the data are missing completely at random and a complete‐case approach is utilized. The obtained results are applied to the estimator of Kendall's
used for testing independence. In this context, the median‐based imputation approach is also considered, and asymptotic properties are explored. In addition, both complete‐case and median imputation approaches are compared in an extensive Monte Carlo study.
Flexible and elastic thermal regulator for multimode intelligent temperature control
Authors: Chen Can , Yu Huitao , Lai Tao , Guo Jun , Qin Mengmeng , Qu Zhiguo , Feng Yiyu , Feng Wei 
Published: November 2023

AbstractAs nonlinear thermal devices, thermal regulators can intelligently respond to temperature and control heat flow through changes in heat transfer capacities, which allows them to reduce energy consumption without external intervention. However, current thermal regulators generally based on high‐quality crystalline‐structure transitions are intrinsically rigid, which may cause structural damage and functional failure under mechanical strain; moreover, they are difficult to integrate into emerging soft electronic platforms. In this study, we develop a flexible, elastic thermal regulator based on the reversible thermally induced deformation of a liquid crystal elastomer/liquid metal (LCE/LM) composite foam. By adjusting the crosslinking densities, the LCE foam exhibits a high actuation strain of 121% with flexibility below the nematic–isotropic phase transition temperature (TNI) and hyperelasticity above TNI. The incorporation of LM results in a high thermal resistance switching ratio of 3.8 over a wide working temperature window of 60°C with good cycling stability. This feature originates from the synergistic effect of fragmentation and recombination of the internal LM network and lengthening and shortening of the bond line thickness. Furthermore, we fabricate a “grid window” utilizing photic‐thermal integrated thermal control, achieving a superior heat supply of 13.7°C at a light intensity of 180 mW/cm2 and a thermal protection of 43.4°C at 1200 mW/cm2. The proposed method meets the mechanical softness requirements of thermal regulator materials with multimode intelligent temperature control.
Special all‐round fillet weld for anchor rods of base‐plate T‐stub connections
Authors: Ali Mahmoud , Mirghaderi Seyed Rasoul , Ghiami Azad Amir Reza , Karami Iman 
Published: November 2023

SummaryThe eccentricity between connected steel parts and the anchor rods in base‐plate T‐stub connections makes base plates the weaker components in tension and compression. Additionally, the oversized holes in base plates lead to irregular placement of anchor rods, resulting in an unsymmetrical shear behavior. Thus, this paper aims to develop a special all‐round fillet weld to connect the anchor rods beneath the base plate concentrically to the steel part, removing the base plate from the load‐transferring chain. Accordingly, design criteria were first developed based on Eurocode's directional method considering all the potential failure modes. Next, results were validated by conducting experimental work. The digital image correlation technique (DIC) was also used to capture the strain distribution developed over the tested specimen till failure. Consequently, numerical analysis was carried out to investigate the fracture strength and the fracture angle and compare the special fillet weld with its equivalent standard one, which has the same weld volume. The results indicated that the proposed design criteria produced safe strength prediction for the developed special all‐round fillet weld. Furthermore, the results revealed that using a special all‐round fillet weld instead of the equivalent standard one can increase the strength by about 8% and improve the ductility of the weld. However, it decreases the stiffness of the weld by about 21%. The fracture surface occurred at from the face of the anchor rod, which produced a higher strength than the predicted tensile strength calculated according to the theoretical throat plane.
Copper and nanocopper toxicity using integrated biomarker response in Pangasianodon hypophthalmus
Authors: Kumar Neeraj , Gismondi Eric , Reddy Kotha Sammi 
Published: November 2023

AbstractThe current study focused on assessing the toxicological effects of copper (Cu) and copper nanoparticles (Cu‐NPs) in acute condition on Pangasianodon hypophthalmus. The median lethal concentration (LC50) for Cu and Cu‐NPs were determined as 8.04 and 3.85 mg L−1, respectively. For the subsequent definitive test, varying concentrations were selected: 7.0, 7.5, 8.0, 8.5, and 9.0 mg L−1 for Cu, and 3.0, 3.3, 3.6, 3.9, and 4.2 mg L−1 for Cu‐NPs. To encompass these concentration levels and assess their toxic effects, biomarkers associated with toxicological studies like oxidative stress, neurotransmission, and cellular metabolism were measured in the liver, kidney, and gill tissues. Notably, during the acute test, the activities of catalase, superoxide dismutase, glutathione‐s‐transferase, glutathione peroxidase, and lipid peroxide in the liver, gill, and kidney tissues were significantly increased due to exposure to Cu and Cu‐NPs. Similarly, acetylcholinesterase activity in the brain was notably inhibited in the presence of Cu and Cu‐NPs when compared to the control group. Cellular metabolic stress was greatly influenced by the exposure to Cu and Cu‐NPs, evident from the considerable elevation of cortisol, HSP 70, and blood glucose levels in the treated groups. Furthermore, integrated biomarker response, genotoxicity, DNA damage in gill tissue, karyotyping in kidney tissue, and histopathology in gill and liver were investigated, revealing tissue damage attributed to exposure to Cu and Cu‐NPs. In conclusion, this study determined that elevated concentrations of essential trace elements, namely Cu and Cu‐NPs, induce toxicity and disrupt cellular metabolic activities in fish.
Genomic and immune landscape in hepatocellular carcinoma: Implications for personalized therapeutics
Authors: Zheng Jiaoyun , Chen Junyan , Wang Shuchao , Yang Dun , Zhou Peng 
Published: November 2023

AbstractHepatocellular carcinoma (HCC) is a globally prevalent malignancy, marked by genetic heterogeneity and intricate tumor microenvironment interactions. In this study, we undertook a detailed single‐cell analysis of six active HCC patients, highlighting strong correlations between gene expression levels and cellular characteristics. UMAP clustering revealed seven distinct cell categories with associated gene expressions. A divergence was observed in tumor cells into high and low cuproptosis groups, each associated with distinct pathways: oxidative stress for the high cuproptosis group and inflammatory and angiogenesis pathways for the low group. CellChat analysis on the TCGA‐LIHC cohort displayed unique intercellular interactions among hepatocytes, T cells, and other cells, with pathways like COLLAGEN and VEGF being pivotal. Functional enrichment analyses exposed pathways enriched between cuproptosis groups, with KEGG emphasizing diseases like Parkinson's. COX survival analysis identified key prognostic genes, revealing distinct survival rates between risk groups in TCGA and GSE14520 cohorts. Mutation data highlighted missense mutations, with TTN, TP53, and CTNNB1 being the most mutated in HCC. Immune infiltration analysis via CIBERSORTx indicated differences between risk groups in NK cells, neutrophils, and other cells. Our drug sensitivity investigation showed significant correlations between model genes and drug responsiveness, emphasizing the importance of patient risk stratification for therapeutic approaches. Further, ATP6V1G1 was recognized in its role in apoptosis and migration in HCC cells. In conclusion, our findings illuminate the complexities of HCC progression, potential predictive genetic markers for drug response, and the pivotal role of ATP6V1G1, suggesting avenues for targeted therapeutic strategies in HCC.
Delineation of groundwater potential zones in Kotagarh block of Kandhamal District, Odisha through geospatial techniques
Authors: Chatterjee Tanmoy , Behera Duryadhan , Goswami Shreerup , Patra Prasanta 
Published: November 2023

AbstractThe integrative approach of remote sensing and geographical information system (GIS) has been a very useful tool for the delineation of groundwater potential zones in any terrain. Various natural factors such as lithology, geomorphology, land use land cover, slope, drainage density, lineament density, etc. control the groundwater recharge and storage. Individual thematic layers have been developed through GIS assigning proper weightage based on storage capacity. The groundwater potential zones in the study region are divided into three classes such as poor, good, and exceptional. The aforesaid methodology has been applied in the selected part of Kotagarh Block of Kandhamal District, Odisha to delineate the possible groundwater potential zones. The present study revealed that the Kotagarh region being a rugged topography is good for groundwater occurrence and storage.
Long-Term Results Following Combined Repair of Atrioventricular Septal Defect with Tetralogy of Fallot
Authors: Schumacher Katja , Marin-Cuartas Mateo , Meier Sabine , Aydin Muhammad Ikbal , Borger Michael A. , Dähnert Ingo , Kostelka Martin , Vollroth Marcel 
Published: November 2023

Abstract
Atrioventricular septal defect (AVSD) in association with tetralogy of Fallot (TOF) is a rare and complex congenital cardiac malformation. We report our institutional experience and outcomes following surgical correction over a 20-year period. Patients who underwent combined surgical AVSD and TOF correction between October 2001 and February 2020 were included for analysis. All patients underwent primary repair. The study data were prospectively collected and retrospectively analyzed. Primary outcomes were in-hospital mortality and long-term freedom from reoperation. During the study period, a total of 10 consecutive patients underwent combined surgical AVSD and TOF correction. Median age at operation was 307 days (IQR 228–457) and median weight was 7.7 kg (IQR 6.7–9.5). Down Syndrome was present in six of the patients. In-hospital mortality was 0%. One patient required re-exploration due to bleeding. Median follow-up was 11 years (IQR 11 months -16 years). There was one case of reoperation due to significant residual ventricular septal defect after 2 months. None of the patients died during follow-up. Combined primary AVSD and TOF repair can be performed with low early mortality and morbidity, as well as a high long-term freedom from reoperation.