bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of cardiac resynchronization therapy in congenital heart disease: A meta‐analysis and systematic review
Authors: Tokavanich Nithi , Mongkonsritragoon Wimwipa , Sattawatthamrong Sireenada , Techasatian Witina , Siranart Noppachai , Prasitlumkum Narut , Navaravong Leenhapong , Chokesuwattanaskul Ronpichai 
Published: December 2023

AbstractIntroductionCardiac resynchronization therapy (CRT) is a standard treatment for patients with heart failure with reduced ejection fraction. However, there is still a gap of evidence in congenital heart disease (CHD) patients regarding resynchronization therapy.MethodsWe performed a meta‐analysis and systematic review of CHD patients who received CRT implantation. We comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane database from inception to June 2023. Studies that reported response rate to CRT, total mortality rate, change in QRS duration, change in left ventricular ejection fraction, and change in New York Heart Association functional class were included.ResultsA total of 14 studies were included in the study. There were 10 studies that reported response rates after implantation. The overall response rate to CRT in CHD patients was 68% (95% confidence interval [CI] 61%–75%, I2 32%). The response rates in patients with systemic right ventricle (RV), systemic left ventricle (LV), and single ventricle were 58% (95% CI 46%–70%, I2 0%), 80% (95% CI 74%–86% I2 14%), and 67% (95% CI 49%–80% I2 0%). Response to CRT in systemic RV was inferior to systemic LV with an odds ratio of 0.38 (95% CI 0.15–0.95, I2 38%). The total mortality rate from seven studies was 12% (95% CI 8%–18%, I2 55%). The parameters which represented ventricular dyssynchrony improved after CRT implantation.ConclusionThe overall response rate to CRT in CHD was 68%. Patients with systemic RV had a lower response rate to CRT when compared to patients with systemic LV. The total mortality rate after CRT implantation was 12%.
Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway
Authors: Jian Hui , Chen Zhi‐Qiang , Du Heng , Liao Ting , Sun Yi‐Chen , Ke Dong , Yu Yang 
Published: December 2023

AbstractGastric cancer results in great cancer mortality worldwide, and inducing ferroptosis dramatically improves the malignant phenotypes of gastric cancer. DNA polymerase epsilon subunit 2 (POLE2) plays indispensable roles in tumorigenesis; however, its involvement and molecular basis in ferroptosis and gastric cancer are not clear. Human gastric cancer cells were infected with lentiviral vectors to knock down or overexpress POLE2, and cell ferroptosis was detected. To further validate the involvement of nuclear factor erythroid 2‐related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4), lentiviral vectors were used. POLE2 expression was elevated in human gastric cancer cells and tissues and closely correlated with clinicopathological features in gastric cancer patients. POLE2 knockdown was induced, while POLE2 overexpression inhibited ferroptosis of human gastric cancer cells, thereby modulating the malignant phenotypes of gastric cancer. Mechanistic studies revealed that POLE2 overexpression elevated NRF2 expression and activity and subsequently activated GPX4, which then prevented lipid peroxidation and ferroptosis in human gastric cancer cells. In contrast, either NRF2 or GPX4 silence significantly prevented POLE2 overexpression‐mediated inductions of cell proliferation, migration, invasion and inhibition of ferroptosis. POLE2 overexpression inhibits ferroptosis in human gastric cancer cells through activating NRF2/GPX4 pathway, and inhibiting POLE2 may be a crucial strategy to treat gastric cancer.
The Mediating Role of Physical Activity Self‐Efficacy in Predicting Moderate‐Intensity Physical Activity in Pregnant People at High Risk for Gestational Diabetes
Authors: Yang Xiao , Han Rongrong , Song Yingli , Zhang Ji , Huang Hui , Zhang Jing , Wang Yan , Gao Lingling 
Published: December 2023

IntroductionGestational diabetes mellitus (GDM) is a common medical complication in pregnancy. Moderate‐intensity physical activity during pregnancy can lower the risk of GDM. However, the relationship between moderate‐intensity physical activity and correlated factors among pregnant people at high risk for GDM remains unknown.MethodsA cross‐sectional study was conducted in China. Two hundred fifty‐two participants completed the Pregnancy Physical Activity Questionnaire, Pregnancy Physical Activity Self‐Efficacy Scale, Physical Activity Knowledge Questionnaire, Physical Activity Social Support Scale, 7‐item Generalized Anxiety Disorder Scale, Edinburgh Postnatal Depression Scale, and a sociodemographic data sheet. Structural equation modeling was used to explore the direct and indirect associations between the study variables.ResultsA total of 51.6% of the participants did not meet the current physical activity guidelines. Only physical activity self‐efficacy was significantly correlated with moderate‐intensity physical activity. Physical activity self‐efficacy mediated the relationship between moderate‐intensity physical activity and knowledge of physical activity, social support for physical activity, and anxiety symptoms. Furthermore, knowledge of physical activity was also associated with improved moderate‐intensity physical activity mediated by reduced anxiety symptoms and increased physical activity self‐efficacy.ConclusionOur study revealed a high prevalence of not meeting current physical activity guidelines among pregnant people at high risk for GDM. Physical activity self‐efficacy played an important mediating role in predicting moderate‐intensity physical activity. Future studies should focus on enhancing self‐efficacy to improve moderate‐intensity physical activity for pregnant people at high risk for GDM.
Family and consensual non‐monogamy: Parents' perceptions of benefits and challenges
Authors: Alarie Milaine 
Published: December 2023

AbstractObjectiveThis study explores the perspectives of parents in open or polyamorous relationships with regards to challenges and benefits of practicing consensual non‐monogamy (CNM).BackgroundStudies show that about one in five people, both in Canada and the United States, have been involved in a CNM relationship in their lifetime, a proportion that is even higher among today's young adults. While we know that many of those people have children, little research has focused on the experiences of parents practicing CNM.MethodThis article begins to fill this gap, drawing on 34 individual semi‐structured interviews with Canadian parents involved in CNM relationships and their partners. The author explores the benefits and challenges associated with raising children in the context of CNM, as experienced by the participants.ResultsThe vast majority of participants argued that the benefits of being polyamorous or in an open relationship considerably outweighed the difficulties they encountered. Six overarching themes emerged from the participants' discourses, namely: (1) social acceptance and legal protection, (2) coming out to children, (3) time management, (4) reconciling family obligations and personal needs, (5) it takes a village to raise children, and (6) teaching important values to children.ConclusionUltimately, this study shows that parents practicing CNM perceive their relationship model as mostly beneficial for themselves, as parents, and for their family.
Mechanical behavior of endodontically treated teeth: A three‐dimensional finite element analysis using displacement vector
Authors: Tanaka Ryousuke , Yamaguchi Satoshi , Takahashi Yusuke , Imazato Satoshi , Hayashi Mikako 
Published: December 2023

AbstractPurposeThis study aimed to analyze the effects of core materials, remaining tooth structures, and interfacial bonding on stress distribution in endodontically treated teeth using finite element analysis (FEA).Materials and MethodsThree‐dimensional FEA was conducted using a reverse engineering technique based on maxillary premolars scanned by micro‐computed tomography. Six models were generated with or without ferrules and with one of the following three abutment systems: metal core, resin core, or resin core with fiber posts. In each model, bonding and debonding were assumed in the dentin and surrounding structures: bonded and debonded models. The maximum principal stress values were recorded, and stress distribution of the entire restored teeth and dentin was generated. Furthermore, the distribution of the displacement vector of the debonded models was generated.ResultsIn comparing the bonded and debonded models, the debonded models showed larger values for tensile stresses than those in bonded models for all abutment models. The models without ferrules rotated around the center of the abutment, whereas those with ferrules did not show remarkable displacement in the analysis.ConclusionFEA assuming fracture of adhesive interface proved to be an effective method to clarify the significance of ferrules. It prevents stress concentration in dentin by reducing the rotation of the abutment, even when the adhesive fails.
Profiles of identity and discrimination and the psychological, health, and academic outcomes of Korean ethnic minority youth in China
Authors: Zhao Zhenqiang , Shen Yishan , Wang Jun 
Published: December 2023

AbstractKorean Chinese is one of the 55 officially recognized ethnic minorities in China. The protective effects of strong bicultural (ethnic and national) identities and the detrimental effects of ethnic discrimination on adjustment outcomes are well documented for ethnic minority youth in W.E.I.R.D. societies. Yet, ethnic minority youth in non‐W.E.I.R.D. societies, such as Korean Chinese, may experience a unique form of discrimination—national discrimination. It is not known how multiple social identities and experiences of dual discrimination may intersect to predict youth adjustment. Thus, this study explored profiles of ethnic and national identities and ethnic and national discrimination among Korean Chinese youth and examined their psychological, health, and academic adjustment. The analytic sample included 267 Korean Chinese youth aged from 12 to 18 (M = 15.21, SD = 1.65) residing in Northeast China. Three latent profiles were identified. The dominant profile of Korean Chinese youth was characterized by high bicultural identity and low ethnic and national discrimination (BILD; n = 171). The second profile was characterized by high bicultural identity and high national discrimination (BIND, n = 50). The third profile was characterized by moderate ethnic and national identities and moderate ethnic and national discrimination (MIMD, n = 46). Regression analyses found that the BILD profile showed fewer depressive symptoms compared to the BIND profile and showed better perceived physical health compared to the MIMD profile. The findings highlight strong bicultural identities as a cultural asset and discrimination—particularly national discrimination—as a contextual risk to Korean Chinese adolescents' well‐being.
Description of six new cyanobacterial species from soil biocrusts on San Nicolas Island, California, in three genera previously restricted to Brazil
Authors: Jusko Brian M. , Johansen Jeffrey R. 
Published: December 2023

AbstractAs the taxonomic knowledge of cyanobacteria from terrestrial environments increases, it remains important to analyze biodiversity in areas that have been understudied to fully understand global and endemic diversity. This study was completed as part of a larger algal biodiversity study of the soil biocrusts of San Nicholas Island, California, USA. Among the taxa isolated were several new species in three genera (Atlanticothrix, Pycnacronema, and Konicacronema) which were described from, and previously restricted to, Brazil. New taxa are described herein using a polyphasic approach to cyanobacterial taxonomy that considers morphological, molecular, ecological, and biogeographical factors. Morphological data corroborated by molecular analysis including sequencing of the 16S rRNA gene, and the associated 16S–23S ITS rRNA region was used to delineate three new species of Atlanticothrix, two species of Pycnacronema, and one species of Konicacronema. The overlap of genera from San Nicolas Island and Brazil suggests that cyanobacterial genera may be widely distributed across global hemispheres, whereas the presence of distinct lineages may indicate that this is not true at the species level. Our data suggest that based upon global wind patterns, cyanobacteria in both Northern and Southern hemispheres of the Americas may have a more recent common ancestor in Northern Africa, but this common ancestry is distant enough that speciation has occurred since transatlantic dispersal.
Temporal dynamics of awakenings from slow‐wave sleep in non‐rapid eye movement parasomnia
Authors: Huijben Iris A. M. , van Sloun Ruud J. G. , Hoondert Bertram , Dujardin Sylvie , Pijpers Angelique , Overeem Sebastiaan , van Gilst Merel M. 
Published: December 2023

SummaryNon‐rapid eye movement parasomnia disorders, also called disorders of arousal, are characterized by abnormal nocturnal behaviours, such as confusional arousals or sleep walking. Their pathophysiology is not yet fully understood, and objective diagnostic criteria are lacking. It is known, however, that behavioural episodes occur mostly in the beginning of the night, after an increase in slow‐wave activity during slow‐wave sleep. A better understanding of the prospect of such episodes may lead to new insights in the underlying mechanisms and eventually facilitate objective diagnosis. We investigated temporal dynamics of transitions from slow‐wave sleep of 52 patients and 79 controls. Within the patient group, behavioural and non‐behavioural N3 awakenings were distinguished. Patients showed a higher probability to wake up after an N3 bout ended than controls, and this probability increased with N3 bout duration. Bouts longer than 15 min resulted in an awakening in 73% and 34% of the time in patients and controls, respectively. Behavioural episodes reduced over sleep cycles due to a reduction in N3 sleep and a reducing ratio between behavioural and non‐behavioural awakenings. In the first two cycles, N3 bouts prior to non‐behavioural awakenings were significantly shorter than N3 bouts advancing behavioural awakenings in patients, and N3 awakenings in controls. Our findings provide insights in the timing and prospect of both behavioural and non‐behavioural awakenings from N3, which may result in prediction and potentially prevention of behavioural episodes. This work, moreover, leads to a more complete characterization of a prototypical hypnogram of parasomnias, which could facilitate diagnosis.
The relationships between multidimensional sleep health and work productivity in individuals with neurological conditions
Authors: Turner Mitchell , Laws Manja , Griffiths Madeline , Turner Kate , Dempsey Leah , Laws Simon M. , Cruickshank Travis 
Published: December 2023

SummaryNumerous studies have reported the negative impacts of poor sleep on work productivity in the general population. However, despite the known sleep issues that individuals living with neurological conditions experience, no study has explored its impact on their work productivity. Sleep health is a concept that includes multiple domains of sleep, measured with a combination of objective and subjective measures. Therefore, this study aimed to ascertain the associations between sleep health and its domains and work productivity in individuals with neurological conditions. Sleep health domains were determined through actigraphy data collected over 1 week and sleep questionnaires. Work productivity was assessed via the Work Productivity and Activity Impairment Questionnaire. A comparison of sleep health scores between demographic variables was performed using Mann–Whitney U and Kruskal–Wallis tests. Associations between the sleep health domains and work productivity were performed using linear regression models. There were no significant differences in sleep health scores between sex, smoking status, education level, employment status or any work productivity domain. Individuals with non‐optimal sleep timing had greater absenteeism (22.99%) than the optimal group. Individuals with non‐optimal sleep quality had an increase in presenteeism (30.85%), work productivity loss (26.44%) and activity impairment (25.81%) compared to those in the optimal group. The findings from this study highlight that self‐reported sleep quality has the largest impact on work productivity. Improving individuals’ sleep quality through triage for potential sleep disorders or improving their sleep hygiene (sleep behaviour and environment) may positively impact work productivity.
Does telling a story in reverse elicit cues to deceit? A replication and extension of Vrij, Leal, Mann and Fisher (2012)
Authors: Brimbal Laure , Jones Angela M. , Quinby Elizabeth A. 
Published: December 2023

AbstractPurposeThe reverse order recall technique has been suggested as tool to improve deception detection accuracy. We conducted a registered replication and extension of Vrij et al., 2012's two experiments, testing whether the reverse order technique increases cues to deception in liars and accuracy in lie detection.MethodsFollowing Vrij et al., 2012, in Experiment 1, participants were interviewed twice—once lying and once telling the truth—about a mission they completed. In both interviews, participants recounted their experience in chronological and reverse order. We coded interviews for cues to deception according to a cognitive approach: those included in Vrij et al., 2012 (replication) and others included in research on the cognitive load approach (extension). In Experiment 2, participants read two transcripts (replication) or viewed two videos (extension) from Experiment 1 and decided whether senders were lying or telling the truth in continuous (replication) and dichotomous judgements (extension).ResultsIn Experiment 1, truth tellers were more detailed and plausible than liars. However, we failed to find the interaction between veracity and route recall reported by the original research on the replication or extensions cues. In Experiment 2, we only found an interaction between veracity and route recall for senders telling the truth on dichotomous lie detection judgement. However, this was not supported when examining overall accuracy.ConclusionsThese findings do not provide support for the reverse order technique as a tool to improve deception detection. We suggest further theoretical development before this technique is trained to practitioners.
Solving the Forecast Combination Puzzle Using Double Shrinkages*
Authors: Liu Li , Hao Xianfeng , Wang Yudong 
Published: December 2023

AbstractThis study develops a new approach that shrinks the forecast combination weights towards equal weights by using weighted least squares and towards zero weight by using regularization constraints. We reveal the significant predictability of excess returns to the S&P500 index that can be achieved by using this double shrinkage combination (DSC). Furthermore, our DSC approach significantly outperforms the naïve equal‐weighted combination, solving the combination puzzle. The equal‐weight shrinkage has greater effect in economic recessions, whereas the zero‐weight shrinkage dominates in economic expansions. The DSC's superior performance over that of the naïve combination is observed in the application of forecasting macroeconomic indicators.
Intrauterine developmental origin, programming mechanism, and prevention strategy of fetal‐originated hypercholesterolemia
Authors: Liu Kexin , Chen Ze , Hu Wen , He Bo , Xu Dan , Guo Yu , Wang Hui 
Published: December 2023

SummaryThere is increasing evidence that hypercholesterolemia has an intrauterine developmental origin. However, the pathogenesis of fetal‐originated is still lacking in a theoretical system, which makes its clinical early prevention and treatment difficult. It has been found that an adverse environment during pregnancy (e.g., xenobiotic exposure) may lead to changes in fetal blood cholesterol levels through changing maternal cholesterol metabolic function and/or placental cholesterol transport function and may also directly affect the liver cholesterol metabolic function of the offspring in utero and continue after birth. Adverse environmental conditions during pregnancy may also raise maternal glucocorticoid levels and promote the placental glucocorticoid barrier opening, leading to fetal overexposure to maternal glucocorticoids. Intrauterine high‐glucocorticoid exposure can alter the liver cholesterol metabolism of offspring, resulting in an increased susceptibility to hypercholesterolemia after birth. Abnormal epigenetic modifications are involved in the intrauterine programming mechanism of fetal‐originated hypercholesterolemia. Some interventions targeted at pregnant mothers or offspring in early life have been proposed to effectively prevent and treat the development of fetal‐originated hypercholesterolemia. In this paper, the recent research progress on fetal‐originated hypercholesterolemia was reviewed, with emphasis on intrauterine maternal glucocorticoid programming mechanisms, in order to provide a theoretical basis for its early clinical warning, prevention, and treatment.
Development and initial validation of the staff perception of residential care environments (SPORE) instrument
Authors: Nordin Susanna , Elf Marie , McKee Kevin 
Published: December 2023

AbstractBackgroundThe impact of the physical environment on healthcare staff well‐being and work performance is well recognised, yet there is a lack of instruments assessing environmental features from the perspective of staff working in residential care facilities (RCFs) for older people.ObjectivesTo develop and provide initial validation of the instrument Staff Perceptions Of Residential care facility Environments (SPORE).DesignAn instrument development and psychometric evaluation study.MethodsBased on material from a British project, items were translated and adapted for Swedish residential care facilities as SPORE. Care staff (N = 200), recruited from 20 Swedish RCFs, completed a questionnaire‐based survey containing the SPORE instrument and two other instruments selected as suitable for use in the validation. In addition, an environmental assessment instrument was used for further validation. Analyses were performed at individual (staff) level and home (RCF) level.ResultsThe SPORE subscales demonstrated good internal consistency reliability and were moderately to strongly correlated at the individual level with the subscales of measures of person‐centred care, and strongly correlated with the same measures at the home level. The SPORE subscales were also highly correlated with the total score of the instrument used to assess the quality of the physical environment.ConclusionThe initial validation indicates that the SPORE instrument is promising for measuring care staff perceptions of environmental features in care facilities for older people. SPORE can be a valuable instrument for use in research and in practice to evaluate the environment as part of working towards high‐quality care.Implications for PracticeThe design of the physical environment within RCFs can affect the staff's health and work performance. The instrument is useful for evaluating the environment and informing decisions about design solutions that support staff in their important work.