bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intratumoral administration of unconjugated Accum™ impairs the growth of pre‐established solid lymphoma tumors
Authors: Bikorimana Jean‐Pierre , El‐Hachem Nehme , Moreau Mathilde , Lawson Christine , Tai Lee‐Hwa , Gonçalves Marina , Abusarah Jamilah , Beaudoin Simon , Stanga Daniela , Plouffe Sebastien , Rafei Moutih 
Published: September 2023

AbstractThe Accum™ technology was initially designed to enhance the bioaccumulation of a given molecule in target cells. It does so by triggering endosomal membrane damages allowing endocytosed products to enter the cytosol, escaping the harsh environmental cues of the endosomal lumen. In an attempt to minimize manufacturing hurdles associated with Accum™ conjugation, we tested whether free Accum™ admixed with antigens could lead to outcomes similar to those obtained with conjugated products. Surprisingly, unconjugated Accum™ was found to promote cell death in vitro, an observation further confirmed on various murine tumor cell lines (EL4, CT‐26, B16, and 4 T1). At the molecular level, unconjugated Accum™ triggers the production of reactive oxygen species and elicits immunogenic cell death while retaining its innate ability to cause endosomal damages. When administered as a monotherapy to animals with pre‐established EL4 T‐cell lymphoma, Accum™ controlled tumor growth in a dose‐dependent manner, and its therapeutic effect relies on CD4 and CD8 T cells. Although unconjugated Accum™ synergizes with various immune checkpoint inhibitors (anti‐CTLA4, anti‐PD‐1, or anti‐CD47) at controlling tumor growth, its therapeutic potency could not be further enhanced when combined with all three tested immune checkpoint inhibitors at once due to its dependency on a specific dosing regimen. In sum, we report in this study an unprecedented new function for unconjugated Accum™ as a novel anticancer molecule. These results could pave the path for a new line of investigation aimed at exploring the pro‐killing properties of additional Accum™ variants as a mean to develop second‐generation anticancer therapeutics.
The development of visual categorization based on high‐level cues
Authors: Peykarjou Stefanie , Hoehl Stefanie , Pauen Sabina 
Published: October 2023

AbstractThis study investigated the development of rapid visual object categorization. N = 20 adults (Experiment 1), N = 21 five to six‐year‐old children (Experiment 2), and N = 140 four‐, seven‐, and eleven‐month‐old infants (Experiment 3; all predominantly White, 81 females, data collected in 2013–2020) participated in a fast periodic visual stimulation electroencephalographic task. Similar categorization of animal and furniture stimuli emerged in children and adults, with responses much reduced by phase‐scrambling (R2 = .34–.73). Categorization was observed from 4 months, but only at 11 months, high‐level cues enhanced performance (R2 = .11). Thus, first signs of rapid categorization were evident from 4 months, but similar categorization patterns as in adults were recorded only from 11 months on.
UK general population's willingness to pay for dental check‐ups
Authors: van der Pol Marjon , Boyers Dwayne , Marashdeh Mousa Mahmoud , Loria‐Rebolledo Luis Enrique 
Published: September 2023

AbstractObjectivesChoices about which dental treatments to provide in a publicly funded system should be guided by the value that the general population place on those treatments. The aim of this study was to estimate United Kingdom (UK) general population willingness to pay (WTP) for dental check‐ups, and to investigate what factors influence WTP.MethodsWTP was elicited using a hypothetical question in an online survey. The sample consisted of 594 participants, nationally representative of the UK general population in terms of age and gender. Regression analysis was used to examine what factors are associated with WTP. Analyses were conducted including and excluding protest answers.ResultsThe mean WTP for a dental check‐up is £31.32 for the full sample and £33.17 excluding protest answers. Respondents on higher incomes and those with higher university education had higher WTP. Respondents in Scotland were WTP less than respondents living in the rest of the UK which may be the result of NHS dental check‐ups being free to patients in Scotland.ConclusionThe general UK population value dental check‐ups. This study provides estimates of WTP for dental check‐ups which can be used in Cost–Benefit Analyses.
Adolescents with substance use referred to child protective services: Does substance use treatment prevent foster care entry?
Authors: LaBrenz Catherine A. , Ohri Faheem , Kim Yeonwoo , Baiden Philip 
Published: September 2023

AbstractAdolescent substance use has been linked to several negative outcomes, which can be exacerbated by exposure to adversity such as child maltreatment. However, few studies have examined the intersection of adolescent substance use and child protective service (CPS) involvement. This study examined the relationship between substance use treatment and entries into foster care among adolescents referred to CPS for maltreatment. Data for this study came from the National Child Abuse and Neglect Data System (NCANDS), an annually reported database that contains information on all CPS reports screened for investigation. NCANDS was merged with county‐level data from the American Community Survey to explore the relationship between treatment and foster care entry while adjusting for contextual factors. Our sample included 2326 adolescents who were referred to CPS in fiscal year (FY) 2018 and were followed until FY 2019 to examine correlates of foster care entry. A series of multilevel logistic regressions were conducted. Approximately 1 in 20 adolescents entered foster care during the study period and 1 in 10 used treatment services prior to foster care entry. Substance use treatment increased the odds of foster care entry (adjusted odds ratios = 2.30, p < 0.05), while adolescents residing in counties with higher percentages of non‐Hispanic White residents had lower odds of foster care entry (adjusted odds ratios = 0.67, p < 0.05). Among adolescents with substance use referred to CPS, substance use treatment increases the likelihood of foster care entry. This may highlight the need to provide services earlier and to ensure that adolescents can access treatment without entering state custody. Future research should explore these relationships in more depth.
Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial alteration
Authors: Kiuchi Jun , Kuriu Yoshiaki , Arita Tomohiro , Shimizu Hiroki , Nanishi Kenji , Takaki Wataru , Ohashi Takuma , Konishi Hirotaka , Yamamoto Yusuke , Morimura Ryo , Shiozaki Atsuishi , Ikoma Hisashi , Kubota Takeshi , Fujiwara Hitoshi , Otsuji Eigo 
Published: September 2023

AbstractAimThere are many reports that preoperative oral antibiotics (OAs) are effective in preventing surgical site infections (SSIs) in colorectal surgery. However, there is no consensus on the optimal dose of OAs. In this study, we investigated the efficacy of OAs in preventing SSIs and the possibility that OAs induce enterobacterial alteration in the intestinal tract.MethodWe performed a retrospective cross‐sectional analysis of 389 patients who underwent R0 resection and stoma creation for colorectal cancer in our department between 2009 and 2020. We focused on the incidence of peristomal candidiasis (PSC) as an indicator of enterobacterial alteration and used kanamycin (KM) and metronidazole (MNZ) as the OAs. A low‐dose group received 1000 mg/day of both KM and MNZ, and a high‐dose group received 2000 mg/day of both KM and MNZ.ResultsSSI occurred in 60 of the 389 cases (15.4%). Regardless of stoma type, SSI was significantly more common in the non‐OA group, while PSC was significantly less common. When examined by OA dose, the incidence of SSI was not significantly different between the low‐dose and high‐dose groups. However, PSC was significantly more common in the high‐dose group than in the non‐OA and low‐dose groups. Analysis of bacterial and fungal levels in stool samples showed that bacterial levels after OAs were significantly lower than before OAs, while fungal levels increased.ConclusionOAs significantly reduce SSI in colorectal cancer surgery. However, excess OAs were significantly associated with the occurrence of PSC without contributing to further reduction in SSI.
Technical assessment in minimally invasive complete mesocolic excision: Is the complete mesocolic excision competency assessment tool valid and reliable?
Authors: Haug Tora Rydtun , Ørntoft Mai‐Britt Worm , Miskovic Danilo , Iversen Lene Hjerrild , Johnsen Søren Paaske , Valentin Jan Brink , Gómez Ruiz Marcos , Benz Stefan , Eeg Storli Kristian , Stearns Adam T. , Madsen Anders Husted 
Published: September 2023

AbstractAimThe complete mesocolic excision competency assessment tool (CMECAT) is a novel tool designed to assess technical skills in minimally invasive complete mesocolic excision (CME) surgery. The aim of this study was to assess construct validity and reliability of CMECAT in a clinical context.MethodColorectal surgeons were asked to submit video recorded laparoscopic CME resections for independent assessment of their technical abilities. The videos were grouped by surgeons' training level, and four established CME experts were recruited as CMECAT assessors. Extended reliability analysis (G‐theory) was applied to describe assessor agreement.ResultsA total of 19 videos and 72 assessments were included in the analysis. Overall, technical skills assessed by CMECAT improved with increased training level: the experts scored significantly better than the untrained surgeons (3.3 vs. 2.5 points; p < 0.01). On right‐sided resections, significantly higher scores were reported with increased training level for all categories and sections, while for left‐sided resections, the variance across groups was smaller and significantly higher scores were only reported for oncological safety describing items. Overall, assessor agreement was high (G‐coefficient: 0.81).ConclusionThis study confirms that CMECAT can be applied to video recorded CME cases for technical skill assessment. Further, it can reliably assess technical performance in right sided CME surgery, where construct validity has now been established. More videos are required to evaluate its validity on left colonic CME. In the future, we hope CMECAT can improve feedback during CME training, serve as a tool in certification processes and contribute to distinguishing CME from conventional surgery in future research.
Q&A
Authors: Hartley Hillary , Givens Garren , Pahlka Jennifer 
Published: October 2023

She was a founder of 18F, the US government's in‐house digital services consultancy, and now she sees her workplace as a laboratory of sorts, staffed by designers as well as developers.As the executive director of the Presidential Innovation Fellows program, he looks to recruit the best and the brightest in technical, design, and entrepreneurial talent.Known for her TED talk, “Coding a Better Government,” Jennifer Pahlka helps design and technology professionals live the idea of government by the people, for the people.
Multiculturalism and Diversity in the Industry: Black Designers Speak Out
Authors: Woods Meshella Eddye 
Published: October 2023

A celebration of accomplished designers and design managers whose success against “lack of diversity” obstacles enables giving back to their communities and mentoring those who are waiting in the wings.A celebration of designers and design managers who are succeeding despite the odds, giving back to their communities, and mentoring those who are waiting in the wings.
The inflation game
Authors: Kuhle Wolfgang 
Published: September 2023

AbstractWe study a game where households buy consumption goods to preempt inflation. This game features a unique equilibrium with high (low) inflation, whenever money supply is high (low). For intermediate levels of money supply, there exist multiple stable equilibria where inflation is either high or low. Equilibria with moderate inflation, however, do not exist, and can thus not be targeted by central banks. That is, depending on agents' equilibrium play, money supply is always either too high or too low for moderate inflation. Finally, we find that inflation rates of durable goods, such as houses, cars, luxury watches, or furniture, are useful leading indicators for changes in overall inflation.
Parent dysregulation and child negativity in relation to parent responses to child negative emotions
Authors: Hafiz Mariam , Nelson Jackie A. , Patel Nishita H. , Holub Shayla C. 
Published: September 2023

AbstractObjectiveThis study examined the effects of mothers' and fathers' emotional dysregulation and their responses to their children's distress, as well as the moderating role of child negative reactivity.BackgroundParents with better emotion regulation strategies tend to provide more supportive and less nonsupportive responses to their children's distress. Child temperamental negative reactivity may create emotionally challenging parenting situations and thus may moderate this relation. However, dyadic effects are less clear; family systems theory suggests parents' dysregulation may crossover to degrade their partners' responses, or parents may compensate for their partners' dysregulation with more constructive responses.MethodParents from 119 families with a 3‐ to 5‐year‐old child (50.4% boys) reported on their emotional dysregulation, responses to child negative emotions, and child negative affectivity. Path models tested actor and partner main effects and interaction effects.ResultsThere were two partner main effects, such that when fathers were more dysregulated, mothers reported providing more supportive and fewer nonsupportive responses to their children. Additionally, two interaction effects were found. Maternal dysregulation was related to increased maternal nonsupport only when child negative affectivity was low. Maternal dysregulation was also related to greater maternal support only when child negative affectivity was high.ConclusionOur findings demonstrate the importance of parent gender roles and compensatory processes.ImplicationsThese results provide enhanced understanding of coparenting dynamics and the combined impact of mother, father, and child negativity, which can be used by practitioners.
Protein profiles reveal MSH6/MSH2 as a potential biomarker for hepatocellular carcinoma with microvascular invasion
Authors: Hong Shengqian , Zhang Jialing , Liu Shiqi , Jin Quan , Li Jingqi , Xia Anliang , Xu JianBo 
Published: September 2023

AbstractAimMicrovascular invasion (MVI) is an independent risk factor for postoperative recurrence and metastasis in hepatocellular carcinoma (HCC). However, the specific protein expression profiles that differentiate HCC with MVI from those without MVI remain unclear.MethodsThe profiles of proteins in early‐stage HCC tissues and normal liver tissues were characterized by quantitative proteomics techniques. Immunohistochemical (IHC) staining was undertaken on tissue microarrays from 80 HCC patients to assess the expression of MSH2 and MSH6. Cell counting, colony formation, migration, and invasion assays were carried out in vitro.ResultsWe identified 5164 proteins in both HCC tissues and adjacent normal liver tissues. Compared to HCC without MVI, 148 upregulated proteins and 97 downregulated proteins were found in HCC with MVI. Particularly noteworthy was the remarkable upregulation of MSH6/MSH2 among these dysregulated proteins in HCC with MVI. Further validation through bioinformatics prediction and IHC confirmed the elevated expression of MSH6/MSH2, which correlated with aggressive disease characteristics and poor prognosis. Receiver operating characteristic curve analyses revealed a substantial area under the curve of 0.761 (specificity 71.79%, sensitivity 73.17%) for the combined use of MSH6/MSH2. Knockdown of MSH6/MSH2 significantly inhibited HCC cell proliferation and invasion in vitro.ConclusionsOur study establishes MSH6 or MSH2 as an oncogene that is prominently overexpressed during HCC progression, which provides new targets for HCC with MVI.
Polysilazane hybrid phenolic resin ceramic aerogels with excellent electromagnetic wave absorption performance
Authors: Wang Ruyao , Wang Fan , Zhu Yaping , Deng Shifeng , Qi Huimin 
Published: September 2023

AbstractAlthough various aerogels with electromagnetic wave (EMW) absorbing properties have been extensively explored, the development of aerogels with excellent wave absorption performance, low density, and great heat resistance has still met profound challenges. Herein, polysilazane hybrid phenolic resin aerogels (PRVS aerogels) were prepared using the vinyl addition reaction of polysilazane and cross‐linking reaction between polysilazane and phenolic resin. A SiOCN ceramic aerogel with multistage pore structure was prepared via a simple and quick freeze‐drying method and polymer‐derived ceramic (PDC) methods. The SiOCN ceramic aerogels exhibited low density (0.15–0.27 g/cm3), good heat‐shielding (thermal conductivity in the range of 0.03–0.04 W/(m·K)), and excellent wave absorption performance (i.e., RL was about –31.6 dB@16.48 GHz and EAB was 3.85 GHz when the thickness of the ceramic aerogel was 1.2 mm). Hence, the ceramic aerogel absorbing materials could meet the requirements of “wide absorption bandwidth, strong reflection loss, lightweight and thi thickness”. Moreover, the mechanism of low weight, heat insulation, and wave absorption properties of the aerogels were also investigated. We believe this work is of great significance in ceramic aerogels prepared by traditional polymers, which may provide new opportunities for new ceramic aerogels with applications ranging from EMW absorption to aerospace and information technology.
Online exams in higher education: Exploring distance learning students' acceptance and satisfaction
Authors: Aristeidou Maria , Cross Simon , Rossade Klaus‐Dieter , Wood Carlton , Rees Terri , Paci Patrizia 
Published: October 2023

AbstractBackgroundResearch into online exams in higher education has grown significantly, especially as they became common practice during the COVID‐19 pandemic. However, previous studies focused on understanding individual factors that relate to students' dispositions towards online exams in ‘traditional’ universities. Moreover, there is little knowledge on university distance learning students' experience of transitioning from in‐person to online exams.ObjectivesThis study investigates the acceptance and satisfaction of university distance learning students in their transitioning from in‐person to online exams, through multiple factors.MethodsWe employed a mixed‐methods study to understand the relationship between assessment and online exam factors (e.g., revision and online exam satisfaction, assessment competencies, invigilation acceptance, exam anxiety and workspace satisfaction). Cluster analysis and interview data contributed to our understanding of students who are ‘strongly positive’ and ‘less positive’ towards online exams.Results and ConclusionsOur findings highlight the overall importance of increasing student confidence by building their assessment competencies throughout their studies and familiarising them early with the technologies and formats to be used in the actual exam. We also shed light on particular student characteristics that relate to reduced online exam acceptance, such as students with disabilities, caring responsibilities and mental health issues, or students who lack access to the necessary technology.ImplicationsThe findings and recommendations of this research contribute to the wider agenda of designing fair and trustworthy online assessment, including exams, for the future.
Reciprocal relations between interparental aggression and symptoms of oppositional defiant and conduct disorders: a seven‐wave cohort study of within‐family effects from preschool to adolescence
Authors: Nobakht Habib Niyaraq , Steinsbekk Silje , Wichstrøm Lars 
Published: October 2023

BackgroundInterparental aggression is believed to increase the risk of behavioral disorders in offspring, and offspring behavioral problems may forecast interparental aggression. However, these assumptions have yet to be put to a strong test. This study, therefore, examined whether increased interparental aggression predicted increased symptoms of oppositional defiant disorder (ODD) and conduct disorder (CD) from preschool to adolescence and vice versa.MethodsA sample (n = 1,077; 49.6% girls) from two birth cohorts of children in Trondheim, Norway, was assessed biennially from age 4 to 16. Children's symptoms of ODD and CD were assessed using semi‐structured clinical interviews of parents (from age 4) and children (from age 8). One of the parents reported on their own and their partner's verbal and physical aggression. A random intercept cross‐lagged model was estimated to test the within‐family relations between interparental aggression, CD, and ODD symptoms.ResultsAcross development, increased interparental aggression predicted increased CD symptoms 2 years later, whereas an increased number of ODD symptoms forecasted increased interparental aggression.ConclusionsThe argumentative/defiant, aggressive, and vindictive behaviors seen in ODD are often directed toward parents and may take a toll on their relationship and possibly foster interparental aggression, whereas aggression between parents may promote symptoms of CD in their offspring, which commonly extend beyond the home. Incorporating effective and non‐aggressive means to solve interparental conflict into parental management programs may reduce the development of symptoms of CDs in children.
Effect of florfenicol on Piscirickettsia salmonis biofilm formed in materials used in salmonid nets, nylon and high‐density polyethylene
Authors: Oliver Cristian , Ruiz Pamela , Vidal José Miguel , Carrasco Carlos , Escalona Carla Estefanía , Barros Javier , Sepúlveda Daniela , Urrutia Homero , Romero Alex 
Published: September 2023

AbstractPiscirickettsiosis is the most prevalent bacterial disease affecting seawater salmon in Chilean salmon industry. Antibiotic therapy is the first alternative to counteract infections caused by Piscirickettsia salmonis. The presence of bacterial biofilms on materials commonly used in salmon farming may be critical for understanding the bacterial persistence in the environment. In the present study, the CDC Biofilm Reactor® was used to investigate the effect of sub‐ and over‐MIC of florfenicol on both the pre‐formed biofilm and the biofilm formation by P. salmonis under the antibiotic stimuli on Nylon and high‐density polyethylene (HDPE) surfaces. This study demonstrated that FLO, at sub‐ and over‐MIC doses, decreases biofilm‐embedded live bacteria in the P. salmonis isolates evaluated. However, it was shown that in the P. salmonis Ps007 strain the presence of sub‐MIC of FLO reduced its biofilm formation on HDPE surfaces; however, biofilm persists on Nylon surfaces. These results demonstrated that P. salmonis isolates behave differently against FLO and also, depending on the surface materials. Therefore, it remains a challenge to find an effective strategy to control the biofilm formation of P. salmonis, and certainly other marine pathogens that affect the sustainability of the Chilean salmon industry.