bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the superiority of (−)‐gallocatechin gallate to (−)‐epigallocatechin‐3‐gallate in protection of diabetic nephropathy of db/db mice
Authors: Xiao Xin , Feng Ling , Cheng Huijun , Ge Huifang , Wang Yijun , Wan Xiaochun , Li Daxiang , Xie Zhongwen 
Published: January 2024

AbstractGCG ((−)‐gallocatechin gallate) and EGCG ((−)‐epigallocatechin‐3‐gallate) are main biologically active polyphenolic compounds in tea leaves, and EGCG has been studied for its potential effects on alleviating diabetic nephropathy (DN). Previous studies showed that GCG exhibited better hypoglycemic and antioxidant efficacy than EGCG. However, the efficacy and molecular mechanisms of GCG in the protection of DN are unknown. In this study, db/db mice were administered with EGCG or GCG orally for 20 weeks to comparatively investigate their effects on DN. These results revealed that GCG was significantly more effective than EGCG in decreasing water intake and urine excretion, reducing fasting blood glucose levels and systolic blood pressure, improving mesenteric artery contractility, enhancing the right renal hemodynamics, and improving key renal function markers. Through transcriptome analysis, S100A8/S100A9, two regulators of interstitial fibrosis, were identified and found to be more sensitive to GCG intervention, which was further confirmed by mRNA and protein expression data. In addition, the molecular docking analysis results demonstrated that GCG displayed a superior binding affinity toward S100A8/S100A9 in comparison to EGCG. Overall, our study found that GCG holds significant potential for the treatment of DN and outperforms EGCG in terms of efficacy.
Revelation of the discrepancy of volatile compounds in fig (Ficus carica) via gas chromatography ion‐mobility spectrometry
Authors: Liu Xinyu , Sun Rui , Wu Qiu , Jia Ming , Yu Tingjuan , Han Yanling , Yang Mingguan , Sun Lei 
Published: January 2024

AbstractThe volatile compounds of fig (Ficus carica) are influenced by various factors. To explore the composition and difference of volatile compounds among figs, gas chromatography ion mobility spectrometry (GC‐IMS) was used to study the volatiles of figs from various regions, diverse cultivars, and after treatment with different drying methods. Aldehydes were the main volatile compounds in Bojihong from Shandong, while esters, ketones, and alcohols were the main volatile compounds in Bojihong from Sichuan and Guangdong. The volatiles of Branswick and Banane were similar, but differed significantly from those of Bojihong. Drying had the most significant effect on fig volatiles, which greatly reduced the content of benzaldehyde, (E)‐2‐hexenal, 2‐methylbutanal aldehydes, lost the content of esters such as isoamyl acetate, butyl acetate, ethyl butyrate, and generated some ketones and ethers. The results showed that Bojihong from Shandong was more suitable for the processing of subsequent fig drying products.
Ibrutinib as first line therapy in chronic lymphocytic leukemia patients over 80 years old: A retrospective real‐life multicenter Italian cohort
Authors: Martino Enrica Antonia , Mauro Francesca Romana , Reda Gianluigi , Laurenti Luca , Visentin Andrea , Frustaci Annamaria , Vigna Ernesto , Pepe Sara , Catania Gioacchino , Loseto Giacomo , Murru Roberta , Chiarenza Annalisa , Sportoletti Paolo , Del Principe Maria Ilaria , Laureana Roberta , Coscia Marta , Galimberti Sara , Ferretti Eleonora , Zucchetto Antonella , Bomben Riccardo , Polesel Jerry , Tedeschi Alessandra , Rossi Davide , Trentin Livio , Neri Antonino , Morabito Fortunato , Gattei Valter , Gentile Massimo 
Published: January 2024

AbstractAlthough chronic lymphocytic leukemia (CLL) predominantly affects the elderly, limited data exists about the outcomes of over 80‐year‐old patients, usually underrepresented in clinical trials. We conducted a multicenter study enrolling 79 consecutive CLL patients ≥80 years at the time of frontline therapy, all treated with ibrutinib. Nearly 48% of cases exhibited unmutated IGHV genes, 32% 17p deletion, and 39.2% TP53 mutations; 63.3% displayed a cumulative illness rating scale (CIRS) > 6. The overall response rate on ibrutinib, computed in 74/79 patients (5 patients excluded for early withdrawal), was 89.9%. After a median follow‐up of 28.9 months, the median progression‐free survival (PFS) and overall survival (OS) were 42.5 and 51.8 months, respectively. CIRS>6 and temporary discontinuation of ibrutinib lasting for 7–30 days were the only parameters associated with a significantly shorter PFS and were both relevant in predicting a shorter PFS compared to patients with CIRS≤6 and therapy discontinuation ≤7 days. The most common grade≥3 adverse events were infections (25.5%), neutropenia (10.1%), and anemia (2.5%). Eighteen patients (22.8%) experienced a cardiovascular event, including grade‐2 atrial fibrillation (n = 9; 11%), grade‐2 hypertension (n = 5; 6%), heart failure (n = 3; 3%), and acute coronary syndrome (n = 1; 1%). Mild bleeding events were observed in 27 patients (34.2%). Ibrutinib was permanently discontinued in 26 patients due to progressive disease (n = 11, including 5 Richter's syndromes), secondary malignancies (n = 6), infections (n = 3), cardiac failure (n = 3), severe bleeding (n = 2), and sudden death (n = 1). In conclusion, our analyses confirmed the overall effectiveness and favorable safety profile of the ibrutinib‐single agent therapeutic approach in CLL patients ≥80 years.
HNRNPA2B1 promotes oral squamous cell carcinogenesis via m6A‐dependent stabilization of FOXQ1 mRNA stability
Authors: Wang Xi , Zhi Min , Zhao Wei , Deng Jiayin 
Published: January 2024

AbstractOral squamous cell carcinoma (OSCC), as a common type of oral malignancy, has an unclear pathogenesis. N6 methyladenosine (m6A) is a reversible and dynamic process that participates in the modulation of cancer pathogenesis and development. As an m6A recognition protein (reader), heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) show abnormally high expression in cancers. Forkhead box Q1 (FOXQ1), an oncogenic transcription factor, controls multiple biological processes (e.g., embryonic development, cell differentiation, and apoptosis, impacting the initiation and progression of cancers by mediating signaling pathways together with epithelial‐mesenchymal transition). Through the Cancer Genome Atlas database screening along with clinical and laboratory experiments, in head and neck squamous cell carcinoma, we found a correlation between HNRNPA2B1 and FOXQ1 gene expression, with shared m6A motifs between HNRNPA2B1 and FOXQ1 mRNA sequences. Silencing or overexpression of HNRNPA2B1 in OSCC cells affected the malignant phenotypes of OSCC cells in vitro, and depletion of HNRNPA2B1 retarded tumor growth in vivo. HNRNPA2B1 could bind to m6A‐modified FOXQ1 mRNA to enhance its mRNA stability, resulting in up‐regulation of FOXQ1 protein expression. To conclude, HNRNPA2B1 was upregulated in OSCC and enhanced OSCC cell malignant phenotypes by stabilizing m6A‐modified FOXQ1 mRNA, eventually aggravating the malignancy and tumorigenicity of OSCC. This study accelerates the recognition of the potency of m6A modification in OSCC and paves the path for OSCC's targeted diagnosis and therapy.
Transdiagnostic effects of therapist self‐disclosure on diverse emotional experiences of clients with emotional disorders and schizophrenia
Authors: Alfi‐Yogev Tal , Kivity Yogev , Atzil‐Slonim Dana , Paz Adar , Igra Libby , Lavi‐Rotenberg Adi , Hasson‐Ohayon Ilanit 
Published: January 2024

AbstractObjectiveDespite the clinical significance of emotional diversity, also known as emodiversity, there has been limited investigation into the therapeutic interventions that influence this construct. In the current study we examined the association between immediate therapist self‐disclosure (TSD) and emodiversity among two diagnostic groups who tend to experience emotional difficulties: people with schizophrenia and people with emotional disorders (i.e., depression and/or anxiety).MethodThe sample comprised 74 clients (37 diagnosed with schizophrenia and 37 with emotional disorders) treated by 45 therapists in a university clinic setting. Following each session, clients self‐reported their emotions, and therapists completed a measure of frequency and centrality of their immediate TSD during the session.ResultsLongitudinal multilevel models indicated that immediate TSD was positively associated with clients' global emodiversity, both at the within‐ and the between‐client levels, as well as with clients' negative emodiversity at the between‐client level. Moreover, clients with emotional disorders and clients with schizophrenia did not differ in the association between immediate TSD and emodiversity. In addition, across groups, clients treated by therapists who used more immediate TSD on average showed greater increases in global emodiversity during treatment.Conclusionsimmediate TSD is associated with clients' ability to experience rich and diverse emotional experiences across different disorders. The theoretical and clinical implications of these findings are discussed.
Analysis of complete hydatidiform mole in one twin using traditional and molecular techniques
Authors: Wang Lijing , Hu Haiyan , Wang Xue , Xu Fengsen , Zhang Hongxia 
Published: January 2024

AbstractA pregnant woman with hydatidiform mole in one twin was misdiagnosed as one of the twins with embryonic arrest. She chose to terminate the pregnancy and developed distant lung metastasis. After chemotherapy, she eventually recovered. This article systematically analyzes the diagnosis and treatment of hydatidiform mole in one twin to increase the awareness and reduce misdiagnosis of the disease.
Benefitting productivity and the environment: Current and future maize cropping systems improve yield while reducing nitrate load
Authors: Dohleman Frank G. , Barten Ty J. , Helland Nicholas , Dahal Subash , Arrizia Juan Lopez , Gehlhar Sarah , Foresman Charles , Mack David , Gillespie Kelly , Archontoulis Sotirios , Castellano Michael J. 
Published: January 2024

AbstractIncreases in cereal crop yield per area have increased global food security. “Era” studies compare historical and modern crop varieties in controlled experimental settings and are routinely used to understand how advances in crop genetics and management affect crop yield. However, to date, no era study has explored how advances in maize (Zea mays L.) genetics and management (i.e., cropping systems) have affected environmental outcomes. Here, we developed a cropping systems era study in Iowa, USA, to examine how yield and nitrate losses have changed from “Old” systems common in the 1990s to “Current” systems common in the 2010s, and to “Future” systems projected to be common in the 2030s. We tested the following hypothesis: If maize yield and nitrogen use efficiency have improved over previous decades, Current and Future maize systems will have benefits to water quality compared to Old systems. We show that not only have maize yield and nitrogen use efficiency (kg grain kg−1 N), on average, improved over time but also yield‐scaled nitrate load + soil nitrate was reduced by 74% and 91% from Old to Current and Future systems, respectively. Continuing these trajectories of improvement will be critical to meet the needs of a growing and more affluent population while reducing deleterious effects of agricultural systems on ecosystem services.
Soil organic carbon data comparison after 85 years and new 13C/12C compositions: The case study of the Ferrara province (Northeastern Italy)
Authors: Salani Gian Marco , Bianchini Gianluca , Brombin Valentina , Natali Claudio 
Published: January 2024

AbstractThe main causes of soil organic matter (SOM) loss are land use (e.g., conventional agriculture) and land‐use change (e.g., conversion of wetlands into croplands). Before World War II and until 1960s, the Ferrara province in the Emilia‐Romagna region (Northeast Italy) enlarged its agricultural production area through drainage of wetlands. After that, the newly drained area was put into intensive agricultural production with practices that proved to be unsustainable, and whose negative effects (depletion of soil organic carbon [SOC] and emissions of greenhouse gases [GHGs], e.g., CO2) have never been quantified. In this work, we estimated the changes in SOC 85 years after the drainage of the palustrine environment, by comparing 1937 SOC measurements with those made in 2022. Comparison of SOC maps from 1937 and 2022 indicates that most of the area suffered a significant SOC loss (∆OC85 years from 0.05 to 18.57 wt%), except for northern areas in which the peat nature of the soil has been preserved. We also measured the 13C/12C on the 2022 soil samples and generated a present‐day map of the SOC isotopic ratios, which could be used in future as a benchmark to evaluate changes in soil carbon stocks and fluxes.
Assessing Postoperative Motor Risk in Insular Low‐Grade Gliomas Patients: The Potential Role of Presurgery MRI Corticospinal Tract Shape Measures
Authors: Yang Zuo‐cheng , Yeh Fang‐cheng , Xue Bo‐wen , Yin Chuan‐dong , Song Xin‐yu , Li Gen , Deng Zheng‐hai , Sun Sheng‐jun , Hou Zong‐gang , Xie Jian 
Published: January 2024

BackgroundInsular low‐grade gliomas (LGGs) are surgically challenging due to their proximity to critical structures like the corticospinal tract (CST).PurposeThis study aims to determine if preoperative CST shape metrics correlate with postoperative motor complications in insular LGG patients.Study TypeRetrospective.Population42 patients (mean age 40.26 ± 10.21 years, 25 male) with insular LGGs.Field Strength/SequenceImaging was performed using 3.0 Tesla MRI, incorporating T1‐weighted magnetization‐prepared rapid gradient‐echo, T2‐weighted space dark‐fluid with spin echo (SE), and diffusional kurtosis imaging (DKI) with gradient echo sequences, all integrated with echo planar imaging.AssessmentShape metrics of the CST, including span, irregularity, radius, and irregularity of end regions (RER and IER, respectively), were compared between the affected and healthy hemispheres. Total end region radius (TRER) was determined as the sum of RER 1 and RER 2. The relationships between shape metrics and postoperative short‐term (4 weeks) and long‐term (>8 weeks) motor disturbances assessing by British Medical Research Council grading system, was analyzed using multivariable regression models.Statistical TestingPaired t‐tests compared CST metrics between hemispheres. Logistic regression identified associations between these metrics and motor disturbances. The models were developed using all available data and there was no independent validation dataset. Significance was set at P < 0.05.ResultsShort‐term motor disturbance risk was significantly related to TRER (OR = 199.57). Long‐term risk significantly correlated with IER 1 (OR = 59.84), confirmed as a significant marker with an AUC of 0.78. Furthermore, the CST on the affected side significantly had the greater irregularity, larger TRER and RER 1, and smaller span compared to the healthy side.Data ConclusionPreoperative evaluation of TRER and IER 1 metrics in the CST may serve as a tool for assessing the risk of postoperative motor complications in insular LGG patients.Level of Evidence2Technical EfficacyStage 2
Efficacy and Safety of Elobixibat in Parkinson's Disease with Chronic Constipation: CONST‐PD Study
Authors: Hatano Taku , Oyama Genko , Shimo Yasushi , Ogaki Kotaro , Nishikawa Noriko , Nakamura Ryota , Tsunemi Taiji , Ogawa Takashi , Eguchi Hiroto , Daida Kensuke , Kurita Naohide , Ueno Shin‐ichi , Fukae Jiro , Sako Wataru , Shiina Kenta , Nakajima Sho , Oji Yutaka , Wakamori Ryo , Saiki Shinji , Nishioka Kenya , Okuzumi Ayami , Taniguchi Daisuke , Takeshige‐Amano Haruka , Fuse Atsuhito , Nakajima Asuka , Kano Masayoshi , Kamo Hikaru , Yamashita Yuri , Shindo Atsuhiko , Yanagisawa Naotake , Hattori Nobutaka 
Published: January 2024

AbstractBackgroundChronic constipation is a common digestive complication of Parkinson's disease (PD).ObjectivesTo verify the usefulness of elobixibat, an ileal bile acid transporter inhibitor, for chronic constipation in PD.MethodsThis double‐blind, placebo‐controlled study consisted of a 2‐week observation/washout period and a 4‐week treatment period. All patients received a Bowel Movement Diary at Week ‐2 and were allocated to elobixibat (10 mg) or placebo at Week 0. Patients visited at Weeks 2 and 4 to report daily spontaneous bowel movements (SBM), stool form, drug use, quality of life (QOL), and safety. Changes in these parameters were assessed.ResultsThe study included 38 patients in the elobixibat group and 39 in the placebo group, and 37 each completed the study. SBM frequency/week (mean ± standard deviation) increased significantly from 4.2 ± 2.6 at baseline to 5.9 ± 3.2 at Week 4 in the elobixibat group (P = 0.0079), but not in the placebo group (4.5 ± 2.7 to 5.3 ± 3.5; P = 0.0889). On analysis of covariance, the between‐group difference in frequency changes at Week 4 (primary endpoint) was not significant after adjustment by baseline and sex (point estimate = 0.8; 95% confidence interval = −0.57 to 2.09, P = 0.2601), although a significant difference (P = 0.0011) was evidenced at Week 1 by a similar analysis. Stool form and scores of satisfaction and stigma were improved by elobixibat. Adverse events were as previously reported.ConclusionsElobixibat improved the SBM frequency, though the defined primary endpoint was not evidenced. QOL parameters (stool consistency and treatment satisfaction) were also improved. Elobixibat may have therapeutic benefits in PD patients suffering from chronic constipation.Trial Registration InformationTrial Registration Number: JPRN‐jRCTs031200172 (submitted: October 26, 2020; first patient enrolment: December 23, 2020; https://jrct.niph.go.jp/en-latest-detail/jRCTs031200172).
Effect of risk aversion on the performance of supply chain and carbon reducing initiatives under asymmetric information
Authors: Wu Qunli , Xu Xinxin , Lin Ronghao , Tian Ye 
Published: January 2024

AbstractThis paper considers a supply chain in which the risk‐averse manufacturer invests in carbon emission reduction (CER) technology and the risk‐averse retailer makes green sales efforts to reduce carbon footprint. The results show that when the information is symmetrical, the two‐part tariff contract can eliminate the double‐marginalization effect. Moreover, when the information is asymmetric, the manufacturer encourages retailer to report true market size and improve green sales effort by providing an incentive contract. This menu of contract ensures the manufacturer obtains more utilities with low carbon emissions. In addition, through the analysis of risk aversion coefficients, we find that under centralized decision, with the improvement of risk aversion awareness, both supply chain players will reduce the green efforts. However, under asymmetric information, compared with the manufacturer, the retailer's higher risk aversion will have an opposite effect on the equilibrium decision‐making, utilities, and carbon footprint of the supply chain.
Big data analytics and corporate financing constraints: Evidence from a developing country
Authors: Chen Hongzhang , Ai Suchen , Xiong Xiancheng , Feng Dawei 
Published: January 2024

AbstractUsing the panel data of A‐share listed companies from 2011 to 2020, we explore the effect of big data analytics (BDA) development on corporate financing constraints. We innovatively design quantitative indicators of BDA with the help of textual methods and found that BDA can significantly mitigate corporate financing constraints after a series of robust and endogeneity test. Moreover, BDA can promote the corporate's total factor productivity (TFP) and increase the financing capacity of corporation. Overall, BDA will significantly ease corporate financing constraints.
Hub‐and‐spoke social networks among Indonesian cocoa farmers homogenise farming practices
Authors: Matous Petr , Bodin Örjan 
Published: January 2024

Abstract

Smallholder farms support the livelihoods of 2.5 billion people and their decisions on how to manage their land has profound consequences for the environment and the food security of billions of people. However, farmers' values, norms and resulting management practices are usually not formed in isolation.

Triangulating multiple analytical, modelling and simulation methods, we investigated if and how social influence exerted through peer‐to‐peer information exchange affect soil nutrition management among 2734 Indonesian smallholder cocoa farmers across 30 different villages.

The results show that the relational structures of these village‐based social networks strongly relate to farmers' use of fertiliser. In villages with highly centralised networks (i.e. hub‐and‐spoke networks where one or very few farmers holds disproportionately central position in the village network), a large majority of farmers report the same fertiliser use, and that practice is typically to avoid using fertilisers. By contrast, in less centralised networks, fertiliser use varies widely.

The observed community‐level distributions of fertiliser use can be most closely reproduced through simulations by complex contagion mechanisms in which social influence is only exerted by opinion leaders that are much more socially connected than others. However, even such leaders' abilities to influence others to change fertiliser use may be limited in practice.

The combination of our quantitative and qualitative findings provides significant policy implications for development programs targeting smallholder farming communities. An important practical lesson is that common interventions which primarily engage socially central farmers may not be effective in stimulating desired transitions in social‐ecological systems.

Read the free Plain Language Summary for this article on the Journal blog.
Face validity of the Kids’ ITP Tools (KIT) in the era of thrombopoietin receptor agonists
Authors: McGuire Catherine , Young Nancy L. , Livingston Joel , Dhir Vinita , Blanchette Victor S. , Kirby‐Allen Melanie , Klaassen Robert J. 
Published: January 2024

AbstractThe Kids’ ITP Tools (KIT) is a questionnaire to assess quality of life of children with immune thrombocytopenia (ITP). The aim of this study was to update this previously validated tool to align with changes in clinical practice, specifically, treatment with thrombopoietin receptor agonists (TPO‐RAs). Children aged 1–18 with ITP and/or their families were recruited to participate in interviews to review the KIT. Twenty‐six interviews were conducted. Based on interview data from children and families, current guidelines, and expert opinion, five changes were made to the KIT in order to improve its face validity.