bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of resection volume on postoperative micturition symptoms and retreatment after transurethral resection of the prostate
Authors: Shin Seung Han , Lee Kwang Suk , Koo Kyo Chul , Cho Kang Su , Hong Chang Hee , Chung Byung Ha , Ryoo Hyun Soo , Ryu Jae Hyun , Kim Yun Beom , Yang Seung Ok , Lee Jeong Kee , Jung Tae Young , Yoo Jeong Woo 
Published: October 2023

Abstract
Purpose
Despite advances in technology, such as advent of laser enucleation and minimally invasive surgical therapies, transurethral resection of the prostate (TURP) remains the most widely performed surgical technique for benign prostatic hyperplasia (BPH). We evaluated resection volume (RV)-derived parameters and analyzed the effect of RV on post-TURP outcomes.

Methods
This observational study used data from patients who underwent TURP at two institutions between January 2011 and December 2021 Data from patients with previous BPH surgical treatment, incomplete data, and underlying disease affecting voiding function were excluded. The collected data included age, prostate-specific antigen, transrectal ultrasound (TRUS)- and uroflowmetry-derived parameters, RV, perioperative laboratory values, perioperative International Prostatic Symptom Score (IPSS), follow-up period, retreatment requirements and interval between the first TURP and retreatment.

Results
In 268 patients without prior BPH medication, there were no differences in prostate volume (PV), transitional zone volume (TZV), or RV according to IPSS. A total of 60 patients started retreatment, including medical or surgical treatment, within the follow-up period. There was a significant difference in RV/PV between the groups without and with retreatment respectively (0.56 and 0.37; p = 0.008). However, preoperative TRUS- and uroflowmetry-derived parameters did not differ between the two groups. Multiple linear regression analysis showed that RV (p = 0.003) and RV/TZV (p = 0.006) were significantly associated with differences in perioperative IPSS. In the multivariate logistic regression analysis, only RV/PV was correlated with retreatment (p = 0.010).

Conclusion
Maximal TURP leads to improved postoperative outcomes and reduced retreatment rate, it may gradually become a requirement rather than an option.
Seasonal variation in sleep time: jackdaws sleep when it is dark, but do they really need it?
Authors: van Hasselt Sjoerd J. , Coscia Massimiliano , Allocca Giancarlo , Vyssotski Alexei L. , Meerlo Peter 
Published: October 2023

AbstractSleep is an important behavioural and physiological state that is ubiquitous throughout the animal kingdom. Birds are an interesting group to study sleep since they share similar sleep features with mammals. Interestingly, sleep time in birds has been shown to vary greatly amongst seasons. To understand the mechanisms behind these variations in sleep time, we did an electro-encephalogram (EEG) study in eight European jackdaws (Coloeus monedula) in winter and summer under outdoor seminatural conditions. To assess whether the amount and pattern of sleep is determined by the outdoor seasonal state of the animals or directly determined by the indoor light–dark cycle, we individually housed them indoors where we manipulated the light–dark (LD) cycles to mimic long winter nights (8:16 LD) and short summer nights (16:8 LD) within both seasons. Jackdaws showed under seminatural outdoor conditions 5 h less sleep in summer compared to winter. During the indoor conditions, the birds rapidly adjusted their sleep time to the new LD cycle. Although they swiftly increased or decreased their sleep time, sleep intensity did not vary. The results indicate that the strong seasonal differences in sleep time are largely and directly driven by the available dark time, rather than an endogenous annual clock. Importantly, these findings confirm that sleep in birds is not a rigid phenomenon but highly sensitive to environmental factors.
The warm Arctic-cold north american pattern in CanESM5 large ensemble simulations: Eurasian influence and uncertainty due to internal variability
Authors: Yu Bin , Lin Hai 
Published: September 2023

AbstractThis study examines the warm Arctic-cold North American pattern (WACNA) and its connection with the warm Arctic-cold Eurasia pattern (WACE) using ERA5 reanalysis and a 50-member ensemble of historical climate simulations produced by CanESM5, the Canadian model participated in CMIP6. The results indicate that a negative WACE-like pattern typically precedes a positive WACNA pattern by one month, and the presence of a negative Asian-Bering-North American (ABNA)-like circulation pattern connects Eurasia and North America, along with the Pacific-North American (PNA)-like pattern. The negative ABNA-like pattern can be attributed to anomalous heating in southern Siberia, which is associated with the negative WACE pattern and its featured Eurasian warming. The negative PNA-like pattern is influenced by negative SST anomalies in the tropical Pacific, resembling tropical ENSO variability. Anomalous temperature advection in the lower troposphere follows the circulation anomaly, which supports the formation of WACNA. Conversely, processes with circulation anomalies of opposite sign result in a negative WACNA pattern. The tropical ENSO variability does not significantly impact the WACNA pattern and its linkage with WACE. CanESM5 simulates the WACNA pattern and WACE-WACNA connection well, with some discrepancies in the magnitude of anomalies compared to ERA5 reanalysis. The uncertainty in the simulated WACNA pattern due to internal climate variability is dominated by two modes of inter-member variability: a southeast-northwest phase shift and a local variation in amplitude.
Factors impacting trial participation in people with motor neuron disease
Authors: Beswick Emily , Johnson Micheala , Newton Judith , Dakin Rachel , Stenson Amy , Abrahams Sharon , Carson Alan , Chandran Siddharthan , Pal Suvankar 
Published: October 2023

AbstractMotor neuron disease (MND) is a rapidly progressive neurodegenerative disorder with limited treatment options. Historically, neurological trials have been plagued by suboptimal recruitment and high rates of attrition. The Motor Neuron Disease–Systematic Multi-Arm Randomised Adaptive Trial (MND–SMART) seeks to identify effective disease modifying drugs. This study investigates person-specific factors affecting recruitment and retention. Improved understanding of these factors may improve trial protocol design, optimise recruitment and retention. Participants with MND completed questionnaires and this was supplemented with clinical data. 12 months after completing the questionnaires we used MND–SMART recruitment data to establish if members of our cohort engaged with the trial. 120 people with MND completed questionnaires for this study. Mean age at participation was 66 (SD = 9), 14% (n = 17) were categorised as long survivors, with 68% (n = 81) of participants male and 60% (n = 73) had the ALS sub-type. Of the 120 study participants, 50% (n = 60) were randomised into MND–SMART and 78% (n = 94) expressed interest an in participating. After the 1-year follow-up period 65% (n = 39) of the 60 randomised participants remained in MND–SMART. Older age was significantly associated with reduced likelihood of participation (OR = 0.92, 95% CI = 0.88–0.96, p = 0.000488). The findings show that people with MND are highly motivated to engage in research, but older individuals remain significantly less likely to participate. We recommend the inclusion of studies to explore characteristics of prospective and current participants alongside trials.
Association between quality of life and emotional overeating — a cross-sectional study in Danish children attending a multicomponent lifestyle camp
Authors: Aagaard Ida , Jakobsen Dorthe Dalstrup , Bruun Jens Meldgaard 
Published: September 2023

AbstractEmotional eating seems to emerge during the transition from childhood to adulthood; however, limited research has explored the association between emotional overeating and quality of life (QoL) in children with overweight and obesity. Therefore, the aim of this study was to examine the association between QoL and emotional overeating in a Danish sample of children with overweight and obesity. The present cross-sectional study is based on baseline questionnaire data from a nonrandomized controlled trial. Children attending a 10-week multicomponent lifestyle camp from October 2020 to March 2022 was invited to participate. Multiple linear regressions were used to examine if QoL was associated with emotional overeating before starting camp. In total, 229 children were included, and 45 children were excluded due to missing data, leaving 184 children in this study. The children had a mean age of 11.8 years (SD ± 1.38), with 60.9% girls and 39.1% boys, and the majority (94.6%) had overweight or obesity defined by a Body Mass Index Standard Deviation Score (BMI-SDS) > 1 SD. On average, children with a high tendency of emotional overeating had a 13.7 (95% CI 18.9; 8.5, p < 0.01) lower QoL score compared to children with a low tendency of emotional overeating. Conclusions: This study shows that children with a high tendency of emotional overeating have lower quality of life, compared to children with a lower tendency of emotional overeating. Due to study limitations, the findings should be supported by further research. (Trial registration: clinicaltrials.gov with ID: NCT04522921).

What is Known:• Emotional eating seems to emerge during the transition from childhood to adulthood.• Limited research has explored the association between quality of life and emotional overeating in children with overweight and obesity.

What is New:• Children with a high tendency of emotional overeating had a lower quality of life compared to children with a lower tendency of emotional overeating.• Emotional overeating was negatively associated with quality of life in children with overweight and obesity.
Glutamic acid intake by formula-fed infants: are acceptable daily intakes appropriate?
Authors: Mennella Julie A. , Smethers Alissa D. , Delahanty Michelle T. , Stallings Virginia A. , Trabulsi Jillian C. 
Published: September 2023

AbstractThe 2017 European Food Safety Authority (EFSA) recommendation of an acceptable daily intake (ADI) of 30 mg glutamic acid/kg bw/day did not take into consideration the primary energy sources during infancy, including infant formulas. In the present study, we determined total daily intakes of glutamic acid in a contemporary cohort of healthy infants who were fed either cow milk formula (CMF) or extensive protein hydrolysate formula (EHF); the formulas differed substantially in glutamic acid content. The infants (n = 141) were randomized to be fed either CMF or EHF. Dietary intakes were determined from weighed bottle methods and/or prospective diet records, and body weights were measured on 14 occasions from 0.5 to 12.5 months. Secondary data analysis determined the glutamic acid content of the diet over time. The trial was registered at http://www.clinicaltrials.gov/ as NCT01700205, 3 October 2012. Glutamic acid intake from formula and other foods was significantly higher in infants fed EHF when compared to CMF. As glutamic acid intake from formula decreased, intake from other nutritional sources steadily increased from 5.5 months. Regardless of formula type, every infant exceeded the ADI of 30 mg/kg bw/day from 0.5 to 12.5 months. Conclusion: Given that the ADI recommendation was not based on actual intake data of primary energy sources during infancy, the present findings on the growing child’s ingestion of glutamic acid from infant formula and the complementary diet may be of interest when developing future guidelines and communications to parents, clinical care providers, and policy makers.

What is Known:• The 2017 re-evaluation of the safety of glutamic acid-glutamates and the recommended acceptable daily intake (ADI) of 30 mg/kg bw/d by the European Food Safety Authority (EFSA) did not include actual intake data of the primary energy sources during infancy.

What is New:• During the first year, glutamic acid intake from infant formula and other food sources exceeded the ADI of 30 mg/kg bw/day.
How to support children to develop and express their coping preferences around minor invasive medical procedures: children’s and parents’ perspectives
Authors: Segers Elisabeth W. , Ketelaar Marjolijn , de Man Marjorie A. C. P. , Schoonhoven Lisette , van de Putte Elise M. , van den Hoogen Agnes 
Published: October 2023

AbstractInvasive medical procedures in hospitals are major sources of stress in children, causing pain and fear. Non-pharmacological interventions are indispensable in effective pain and fear management. However, these interventions must be personalized to be effective. This qualitative study aims to gain insight into children’s and parents’ experiences, needs, and wishes related to supporting children to develop and express their coping preferences for dealing with pain and fear during minor invasive medical procedures in order to decrease pain and fear. A qualitative study using thematic analysis was performed. Data were collected through semi-structured interviews with children and parents who had undergone at least five minor invasive medical procedures in the last year. Nineteen children (8–18 years) and fourteen parents were interviewed individually. The experiences, needs, and wishes expressed in the interviews could be classified into one overarching theme, that of the personal process, and two content-related sub-themes: feeling trust and gaining control. The personal process was divided into two different phases, that of developing and of expressing coping preferences. Children and parents both reported it as a continuous process, different for every child, with their own unique needs. Children and parents expected personalized attention and tailored support from professionals. Conclusion: Professionals must combine clinical skills with child-tailored care. In the process of searching for and communicating about coping preferences, children’s unique needs and personal boundaries will thereby be respected. This gives children and parents increased trust and control during invasive medical procedures.

What is Known:• Untreated pain and stress caused by medical procedures can have severe and important short- and long-term consequences for children. Personalized non-pharmacological interventions are an essential element of procedural pain management.

What is New:• A personalized coping strategy is important for children when undergoing medical procedures. Each individual child has a personal way of expressing their own coping strategy. Children and their parents need information and the space to develop and express their individual coping preferences.• Children and parents expect to receive child-tailored care from professionals including respect for their own, unique needs and boundaries. Professionals should build trustful relationships and provide appropriately tailored autonomy around medical procedures.
Global existence and non-uniqueness of 3D Euler equations perturbed by transport noise
Authors: Hofmanová Martina , Lange Theresa , Pappalettera Umberto 
Published: October 2023

AbstractWe construct Hölder continuous, global-in-time probabilistically strong solutions to 3D Euler equations perturbed by Stratonovich transport noise. Kinetic energy of the solutions can be prescribed a priori up to a stopping time, that can be chosen arbitrarily large with high probability. We also prove that there exist infinitely many Hölder continuous initial conditions leading to non-uniqueness of solutions to the Cauchy problem associated with the system. Our construction relies on a flow transformation reducing the SPDE under investigation to a random PDE, and convex integration techniques introduced in the deterministic setting by De Lellis and Székelyhidi, here adapted to consider the stochastic case. In particular, our novel approach allows to construct probabilistically strong solutions on $$[0,\infty )$$

[
0
,
∞
)

directly.
Sim-GAIL: A generative adversarial imitation learning approach of student modelling for intelligent tutoring systems
Authors: Li Zhaoxing , Shi Lei , Wang Jindi , Cristea Alexandra I. , Zhou Yunzhan 
Published: October 2023

AbstractThe continuous application of artificial intelligence (AI) technologies in online education has led to significant progress, especially in the field of Intelligent Tutoring Systems (ITS), online courses and learning management systems (LMS). An important research direction of the field is to provide students with customised learning trajectories via student modelling. Previous studies have shown that customisation of learning trajectories could effectively improve students’ learning experiences and outcomes. However, training an ITS that can customise students’ learning trajectories suffers from cold-start, time-consumption, human labour-intensity, and cost problems. One feasible approach is to simulate real students’ behaviour trajectories through algorithms, to generate data that could be used to train the ITS. Nonetheless, implementing high-accuracy student modelling methods that effectively address these issues remains an ongoing challenge. Traditional simulation methods, in particular, encounter difficulties in ensuring the quality and diversity of the generated data, thereby limiting their capacity to provide intelligent tutoring systems (ITS) with high-fidelity and diverse training data. We thus propose Sim-GAIL, a novel student modelling method based on generative adversarial imitation learning (GAIL). To the best of our knowledge, it is the first method using GAIL to address the challenge of lacking training data, resulting from the issues mentioned above. We analyse and compare the performance of Sim-GAIL with two traditional Reinforcement Learning-based and Imitation Learning-based methods using action distribution evaluation, cumulative reward evaluation, and offline-policy evaluation. The experiments demonstrate that our method outperforms traditional ones on most metrics. Moreover, we apply our method to a domain plagued by the cold-start problem, knowledge tracing (KT), and the results show that our novel method could effectively improve the KT model’s prediction accuracy in a cold-start scenario.
Evaluating ChatGPT responses in the context of a 53-year-old male with a femoral neck fracture: a qualitative analysis
Authors: Zhou Yushy , Moon Charles , Szatkowski Jan , Moore Derek , Stevens Jarrad 
Published: September 2023

Abstract
Purpose
The integration of artificial intelligence (AI) tools, such as ChatGPT, in clinical medicine and medical education has gained significant attention due to their potential to support decision-making and improve patient care. However, there is a need to evaluate the benefits and limitations of these tools in specific clinical scenarios.

Methods
This study used a case study approach within the field of orthopaedic surgery. A clinical case report featuring a 53-year-old male with a femoral neck fracture was used as the basis for evaluation. ChatGPT, a large language model, was asked to respond to clinical questions related to the case. The responses generated by ChatGPT were evaluated qualitatively, considering their relevance, justification, and alignment with the responses of real clinicians. Alternative dialogue protocols were also employed to assess the impact of additional prompts and contextual information on ChatGPT responses.

Results
ChatGPT generally provided clinically appropriate responses to the questions posed in the clinical case report. However, the level of justification and explanation varied across the generated responses. Occasionally, clinically inappropriate responses and inconsistencies were observed in the generated responses across different dialogue protocols and on separate days.

Conclusions
The findings of this study highlight both the potential and limitations of using ChatGPT in clinical practice. While ChatGPT demonstrated the ability to provide relevant clinical information, the lack of consistent justification and occasional clinically inappropriate responses raise concerns about its reliability. These results underscore the importance of careful consideration and validation when using AI tools in healthcare. Further research and clinician training are necessary to effectively integrate AI tools like ChatGPT, ensuring their safe and reliable use in clinical decision-making.
Effect of atmospheric conditions and VPRM parameters on high-resolution regional CO2 simulations over East Asia
Authors: Seo Min-Gyung , Kim Hyun Mee , Kim Dae-Hui 
Published: October 2023

AbstractAtmospheric CO2 concentrations are largely affected by the surface CO2 flux and atmospheric wind. To estimate atmospheric CO2 concentrations over East Asia, the effects of atmospheric conditions and the parameters of Vegetation Photosynthesis and Respiration Model (VPRM) that simulates biogenic CO2 concentrations were evaluated using the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) model. The VPRM in WRF-Chem requires parameter optimization for the experimental period and region. Total six experiments with two atmospheric fields (final analysis; FNL and fifth generation of European Centre for Medium-range Weather Forecasts atmospheric reanalysis; ERA5) and three VPRM parameter tables (US, Li, and Dayalu) were conducted to investigate the appropriate atmospheric field and VPRM parameter table for East Asia. For validation, two types of wind observations (SYNOP and SONDE) and two types of CO2 observations (surface CO2 observations and OCO-2 XCO2 observations) were used. The experiments using FNL showed a lower RMSE for surface winds, whereas those using ERA5 showed a lower RMSE for upper-air winds. On average, the surface wind RMSE in the experiments using FNL was lower than that using ERA5. With respect to surface CO2 observations, the experiments using the Li table showed relatively lower RMSEs compared to those using other tables. With respect to OCO-2 XCO2 observations, the Li table with FNL showed lower RMSEs than other combinations. Overall, the combination of the Li table and FNL was the most appropriate for simulating CO2 concentrations in East Asia using WRF-Chem with VPRM.