bluuebunny/crossref_metadata_2025_split huggingface dataset:
SHC: soft-hard correspondences framework for simplifying point cloud registration
Authors: Chen Zhaoxiang , Yu Feng , Liu Shuqing , Cao Jiacheng , Xiao Zhuohan , Jiang Minghua 
Published: January 2024

AbstractPoint cloud registration is a multifaceted problem that involves a series of procedures. Many deep learning methods employ complex structured networks to achieve robust registration performance. However, these intricate structures can amplify the challenges of network learning and impede gradient propagation. To address this concern, the soft-hard correspondence (SHC) framework is introduced in the present paper to streamline the registration problem. The framework encompasses two modes: the hard correspondence mode, which transforms the registration problem into a correspondence pair search problem, and the soft correspondence mode, which addresses this new problem. The simplification of the problem provides two advantages. First, it eliminates the need for intermediate operations that lead to error fusion and counteraction, thereby improving gradient propagation. Second, a perfect solution is not necessary to solve the new problem, since accurate registration results can be achieved even in the presence of errors in the found pairs. The experimental results demonstrate that SHC successfully simplifies the registration problem. It achieves performance comparable to complex networks using a simple network and can achieve zero error on datasets with perfect correspondence pairs.
Risk of flare or relapse in patients with immune-mediated diseases following SARS-CoV-2 vaccination: a systematic review and meta-analysis
Authors: Shabani Mahya , Shobeiri Parnian , Nouri Shadi , Moradi Zahra , Amenu Robel Assefa , Mehrabi Nejad Mohammad-Mehdi , Rezaei Nima 
Published: January 2024

Abstract
Background
Patients with autoimmune and immune-mediated diseases (AI-IMD) are at greater risk of COVID-19 infection; therefore, they should be prioritized in vaccination programs. However, there are concerns regarding the safety of COVID-19 vaccines in terms of disease relapse, flare, or exacerbation. In this study, we aimed to provide a more precise and reliable vision using systematic review and meta-analysis.

Methods
PubMed-MEDLINE, Embase, and Web of Science were searched for original articles reporting the relapse/flare in adult patients with AI-IMD between June 1, 2020 and September 25, 2022. Subgroup analysis and sensitivity analysis were conducted to investigate the sources of heterogeneity. Statistical analysis was performed using R software.

Results
A total of 134 observations of various AI-IMDs across 74 studies assessed the rate of relapse, flare, or exacerbation in AI-IMD patients. Accordingly, the crude overall prevalence of relapse, flare, or exacerbation was 6.28% (95% CI [4.78%; 7.95%], I2 = 97.6%), changing from 6.28% (I2 = 97.6%) to 6.24% (I2 = 65.1%) after removing the outliers. AI-IMD patients administering mRNA, vector-based, and inactive vaccines showed 8.13% ([5.6%; 11.03%], I2 = 98.1%), 0.32% ([0.0%; 4.03%], I2 = 93.5%), and 3.07% ([1.09%; 5.9%], I2 = 96.2%) relapse, flare, or exacerbation, respectively (p-value = 0.0086). In terms of disease category, nephrologic (26.66%) and hematologic (14.12%) disorders had the highest and dermatologic (4.81%) and neurologic (2.62%) disorders exhibited to have the lowest crude prevalence of relapse, flare, or exacerbation (p-value < 0.0001).

Conclusion
The risk of flare/relapse/exacerbation in AI-IMD patients is found to be minimal, especially with vector-based vaccines. Vaccination against COVID-19 is recommended in this population.
Androgen deficiency is associated with a better prognosis in glioblastoma
Authors: Fariña-Jerónimo Helga , Martín-Ramírez Rita , González-Fernández Rebeca , Medina Lilian , de Vera Antonia , Martín-Vasallo Pablo , Plata-Bello Julio 
Published: January 2024

Abstract
Background
The androgen receptor (AR) has been demonstrated to play a role in the pathogenesis of glioblastoma; however, the implications of circulating testosterone levels in the biology of glioblastoma remain unknown.

Aim
This study aimed to analyze the association between circulating testosterone levels and the prognosis of patients with glioblastoma.

Methods
Forty patients with primary glioblastoma were included in the study. The main prognostic endpoint was progression-free survival (PFS). Circulating testosterone levels were used to determine the state of androgen deficiency (AD). AR expression was analyzed by reverse-transcriptase polymerase chain reaction, Western blot, and immunofluorescence. Survival analysis was performed using the log-rank test and univariate and multivariate Cox regression analysis.

Results
Most of the patients showed AR expression, and it was mainly located in the cytoplasm, as well as in the nucleus of tumor cells. Patients with AD presented a better PFS than those patients with normal levels (252.0 vs. 135.0 days; p = 0.041). Furthermore, normal androgenic status was an independent risk factor for progression in a multivariate regression model (hazard ratio = 6.346; p = 0.004).

Conclusion
Circulating testosterone levels are associated with the prognosis of glioblastoma because patients with AD show a better prognosis than those with normal androgenic status.
The spatial patterning of emergency demand for police services: a scoping review
Authors: Langton Samuel , Ruiter Stijn , Schoonmade Linda 
Published: January 2024

AbstractThis preregistered scoping review provides an account of studies which have examined the spatial patterning of emergency reactive police demand (ERPD) as measured by calls for service data. To date, the field has generated a wealth of information about the geographic concentration of calls for service, but the information remains unsynthesised and inaccessible to researchers and practitioners. We code our literature sample (N = 79) according to the types of demand studied, the spatial scales used, the theories adopted, the methods deployed and the findings reported. We find that most studies focus on crime-related call types using meso-level (e.g., neighborhood) spatial scales. Descriptive methods demonstrate the non-random distribution of calls, irrespective of their type, while correlational findings are mixed, providing minimal support for theories such as social disorganization theory. We conclude with suggestions for future research, focusing on how the field can better exploit open data sources to ‘scale-up’ analyses.
Host genotype, soil composition, and geo-climatic factors shape the fonio seed microbiome
Authors: Tabassum Naheed , Ahmed Hanin Ibrahim , Parween Sabiha , Sheikh Arsheed H. , Saad Maged M. , Krattinger Simon G. , Hirt Heribert 
Published: January 2024

Abstract
Background
Fonio (Digitaria exilis), an orphan millet crop, is the oldest indigenous crop in West Africa. Although the yield is low due to pre-domestication characteristics, the quick maturation time, drought tolerance, and the ability to thrive on poor soils make fonio a climate-smart crop. Being holobionts, plants evolve in close interaction with microbial partners, which is crucial for plant phenology and fitness. As seeds are the bottleneck of vertically transmitting plant microbiota, we proposed to unravel the seed microbiome of the under-domesticated and resilient crop fonio. Our study investigated the bacterial seed endophyte diversity across 126 sequenced fonio accessions from distinct locations in West Africa. We conducted a correlation study of the structures and functions of the seed-associated microbiomes with the native geo-climate and soil structure data. We also performed Genome-wide association studies (GWAS) to identify genetic loci associated with seed endophyte diversity.

Result
We report that fonio millet has diverse heritable seed endophytic taxa. We analyzed the seed microbiomes of 126 fonio accessions and showed that despite the diversity of microbiomes from distinct geographical locations, all fonio genetic groups share a core microbiome. In addition, we observed that native soil composition, geo-climatic factors, and host genotype correlate with the seed microbiomes. GWAS analysis of genetic loci associated with endophyte seed bacterial diversity identified fonio SNPs associated with genes functioning in embryo development and stress/defense response.

Conclusion
Analysis of the seed endophyte of the climate-smart crop fonio indicated that despite possessing a heritable core microbiome, native conditions may shape the overall fonio seed microbiomes in different populations. These distinct microbiomes could play important roles in the adaptation of fonio to different environmental conditions. Our study identified the seed microbiome as a potential target for enhancing crop resilience to climate stress in a sustainable way.
BTLA biology in cancer: from bench discoveries to clinical potentials
Authors: Andrzejczak Anna , Karabon Lidia 
Published: January 2024

AbstractImmune checkpoints play a critical role in maintaining the delicate balance of immune activation in order to prevent potential harm caused by excessive activation, autoimmunity, or tissue damage. B and T lymphocyte attenuator (BTLA) is one of crucial checkpoint, regulating stimulatory and inhibitory signals in immune responses. Its interaction with the herpes virus entry mediator (HVEM) plays an essential role in negatively regulating immune responses, thereby preserving immune homeostasis. In cancer, abnormal cells evade immune surveillance by exploiting checkpoints like BTLA. Upregulated BTLA expression is linked to impaired anti-tumor immunity and unfavorable disease outcomes. In preclinical studies, BTLA-targeted therapies have shown improved treatment outcomes and enhanced antitumor immunity. This review aims to provide an in-depth understanding of BTLA’s biology, its role in various cancers, and its potential as a prognostic factor. Additionally, it explores the latest research on BTLA blockade in cancer immunotherapy, offering hope for more effective cancer treatments.
Prospecting during egg laying informs incubation recess movements of eastern wild turkeys
Authors: Bakner Nicholas W. , Ulrey Erin E. , Collier Bret A. , Chamberlain Michael J. 
Published: January 2024

Abstract
Background
Central place foragers must acquire resources and return to a central location after foraging bouts. During the egg laying (hereafter laying) period, females are constrained to a nest location, thus they must familiarize themselves with resources available within their incubation ranges after nest site selection. Use of prospecting behaviors by individuals to obtain knowledge and identify profitable (e.g., resource rich) locations on the landscape can impact demographic outcomes. As such, prospecting has been used to evaluate nest site quality both before and during the reproductive period for a variety of species.

Methods
Using GPS data collected from female eastern wild turkeys (Meleagris gallopavo silvestris) across the southeastern United States, we evaluated if prospecting behaviors were occurring during laying and what landcover factors influenced prospecting. Specifically, we quantified areas prospected during the laying period using a cluster analysis and the return frequency (e.g., recess movements) to clustered laying patches (150-m diameter buffer around a clustered laying period location) during the incubation period.

Results
The average proportion of recess movements to prospected locations was 56.9%. Nest fate was positively influenced (μ of posterior distribution with 95% credible 0.19, 0.06–0.37, probability of direction = 99.8%) by the number of patches (90-m diameter buffer around a clustered laying period location) a female visited during incubation recesses. Females selected for areas closer to the nest site, secondary roads, hardwood forest, mixed pine-hardwood forest, water, and shrub/scrub, whereas they avoided pine forest and open-treeless areas.

Conclusions
Our findings suggest that having a diverse suite of clustered laying patches to support incubation recesses is impactful to nest fate. As such, local conditions within prospected locations during incubation may be key to successful reproductive output by wild turkeys. We suggest that prospecting could be important to other phenological periods. Furthermore, future research should evaluate how prospecting for brood-rearing locations may occur before or during the incubation period.
Coproduction of bio-microbicide and silver nano-microbicide mediated by endospore-forming Bacillus and their synergetic control of plant disease
Authors: You Yuxin , Wang Chen , Abdallah Yasmine , Liu Quanhong , Liu Chentao , Luo Jinyan , Dai Dejiang , Al-Rejaie Salim S. , Mohany Mohamed , Li Bin , Ogunyemi Solabomi Olaitan , An Qianli 
Published: January 2024

Abstract
Background
One-pot synthesis of metal nanoparticles under ambient temperature and pressure using reducing and stabilizing materials from microbes is energy-effective and ecofriendly, but upstream extraction of biological raw materials and downstream purification of nanoparticles from bioreactors are laborious and expensive. To simplify the productive process for using metal nanoparticles as microbicides to control plant pathogens, we use an endospore-forming Bacillus biocontrol agent to produce the nano-microbicide and use the bacterial raw materials as bio-microbicides together with the nano-microbicide.

Results
Bacillus cells at the stationary phase form endospores and tolerate Ag+ and Ag nanoparticles (AgNPs), while the cell-free culture supernatant (CFCS) mediates the synthesis of AgNPs. AgNPs produced from the Bacillus culture and CFCS show similar physical, chemical, and electrical characteristics, and bactericidal and anti-biofilm activities. Moreover, the diluted products effectively protect the kiwifruit leaves from the infection of the pathogen Pseudomonas syringae pv. actinidiae.

Conclusions
This coproduction of bio-microbicide and nano-microbicide is a totally green one-pot synthesis process without extraction and purification and without production of waste and can be easily scaled up using the existing fermentation processing of Bacillus biocontrol agents. The application of the synergistic bio-microbicide and nano-microbicide can effectively control the bacterial canker disease of kiwifruit plants.

Graphical Abstract
STEM learning opportunities and career aspirations: the interactive effect of students’ self-concept and perceptions of STEM professionals
Authors: Chen Yu , So Winnie Wing Mui , Zhu Jinxin , Chiu Stephen Wing Kai 
Published: January 2024

Abstract
Background
Students’ positive perceptions of scientists or engineers have been reported to be positively related to their science, technology, engineering, and mathematics (STEM) career aspirations. However, other research indicates that positive perceptions of experts in these fields might not necessarily lead to students’ pursuit of STEM careers. Self-concept, defined as one’s perceived abilities in specific academic domains, likely plays a moderating role in the relationship between perceptions and career aspirations according to the motivational theory of role modelling. Moreover, students’ perceptions of STEM professionals might be sourced from STEM-related media and school experiences. Therefore, through running a moderated mediation model, this study examined whether and how the influences of media consumption and school STEM learning opportunities on career aspirations would be mediated by perceptions of STEM professionals, and whether the mediation effect would be conditional on students’ self-concept.

Methods
Data were collected through an online survey of 608 primary and secondary school students from Hong Kong, and were analysed using structural equation modelling.

Results
Results revealed that the students’ positive perceptions of STEM professionals were positively associated with their career aspirations, and mediated the links from media consumption and school opportunities to career aspirations. In addition, this mediated pathway depended on STEM self-concept, such that perceptions of STEM professionals were only linked with STEM career aspirations for adolescents with average or high levels of self-concept.

Conclusions
The findings of this study suggest the need to pay attention to the STEM perceptions and self-concept interaction while designing and implementing learning activities to connect a diversity of students with STEM careers. It is not only important to foster students’ self-concept, but also to enrich their knowledge of diverse occupations, so as to help diversify their perceptions that being professionals in these fields is desirable and attainable, and to eventually inspire more student engagement and participation in STEM.
Unsupervised clustering of bitcoin transactions
Authors: Vlahavas George , Karasavvas Kostas , Vakali Athena 
Published: January 2024

AbstractSince its inception in 2009, Bitcoin has become and is currently the most successful and widely used cryptocurrency. It introduced blockchain technology, which allows transactions that transfer funds between users to take place online, in an immutable manner. No real-world identities are needed or stored in the blockchain. At the same time, all transactions are publicly available and auditable, making Bitcoin a pseudo-anonymous ledger of transactions. The volume of transactions that are broadcast on a daily basis is considerably large. We propose a set of features that can be extracted from transaction data. Using this, we apply a data processing pipeline to ultimately cluster transactions via a k-means clustering algorithm, according to the transaction properties. Finally, according to these properties, we are able to characterize these clusters and the transactions they include. Our work mainly differentiates from previous studies in that it applies an unsupervised learning method to cluster transactions instead of addresses. Using the novel features we introduce, our work classifies transactions in multiple clusters, while previous studies only attempt binary classification. Results indicate that most transactions fall into a cluster that can be described as common user transactions. Other clusters include transactions made by online exchanges and lending services, those relating to mining activities as well as smaller clusters, one of which contains possibly illicit or fraudulent transactions. We evaluated our results against an online database of addresses that belong to known actors, such as online exchanges, and found that our results generally agree with them, which enhances the validity of our methods.
Involving patients and clinicians in the development of a randomised clinical trial protocol to assess spinal manual therapy versus nerve root injection for patients with lumbar radiculopathy: a patient and public involvement project to inform the SALuBRITY trial design
Authors: Ryf Corina , Hofstetter Léonie , Clack Lauren , Hincapié Cesar A. 
Published: January 2024

Abstract
Background
Spinal manual therapy and corticosteroid nerve root injection are commonly used to treat patients with lumbar radiculopathy. The SALuBRITY trial—a two parallel group, double sham controlled, randomised clinical trial—is being developed to compare their effectiveness. By gathering patients’ and clinicians’ perspectives and involving them in discussions related to the trial research question and objectives, proposed trial recruitment processes, methods, and outcome measures, we aimed to improve the relevance and quality of the SALuBRITY trial.

Methods
We involved patients with lived experience of lumbar radiculopathy (n = 5) and primary care clinicians (n = 4) with experience in the treatment of these patients. Involvement activities included an initial kick-off event to introduce the project, establishing a shared purpose statement, and empowering patient and clinician advisors for their involvement, followed by semi-structured group and individual interviews, and questionnaires to evaluate the experience throughout the project.

Results
Both patient and clinician advisors endorsed the significance and relevance of the trial’s objectives. Patients assessed the proposed trial methods as acceptable within the context of a trusting patient-clinician relationship. A trial recruitment and enrolment target time of up to five days was regarded as acceptable, although patients with chronic radiculopathy may need more time to consider their trial participation decision. All advisors reached consensus on the acceptability of a medication washout phase of 12- to 24-h before pain outcome measurement, with the inclusion of a rescue medication protocol. Both advisory groups preferred leg pain over back pain as the primary clinical outcome, with patient advisors advocating for personalized primary pain localization. Furthermore, patients requested expanding the pain, enjoyment, and general activity scale with peak pain intensity, rather than average pain alone. Patient and clinician advisors evaluated their engagement in clinical research as meaningful and impactful.

Conclusion
Patient and public involvement resulted in important and relevant considerations for the SALuBRITY trial, spanning all research phases. These findings hold promise for enhancing the trial’s quality and relevance and improving its translation into clinical practice.
The golden ratio—dispelling the myth
Authors: Naini Farhad B. 
Published: January 2024

Abstract
Background
The purpose of this article is to explore the claims often cited in scientific journals regarding the golden ratio, and its proposed link to beauty and idealized forms in nature, including idealized human proportions.

Main body
Claims made in the nineteenth century through to the modern day in the clinical literature do not appear to be supported by evidence.

Short conclusions
There is no convincing evidence that the golden ratio is linked to idealized human proportions or facial beauty. There is currently no evidence to support the use of the golden ratio in orthognathic or facial aesthetic/reconstructive surgical planning or analysis of results.