bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudio sobre la viabilidad y operatividad del arbitraje interno en materia tributaria en Ecuador
Authors: Romero Jarrín Fabian Alejandro , Ordoñez Chica Daniel Fernando , Argudo Polo Jorge Alejandro 
Published: February 2024

Introducción: Las disposiciones de la Ley Orgánica para el Desarrollo Económico y Sostenibilidad Fiscal relativas a la transigibilidad de las obligaciones tributarias, reavivaron el debate sobre el advenimiento del arbitraje como instrumento alternativo de solución de conflictos. Objetivos: El objetivo del presente estudio es determinar, los elementos clave que permitirían su viabilidad y eventual aplicación. Metodología: Frente a la problemática propuesta, la presente investigación adopta un enfoque cualitativo no experimental, y se articula por medio de la exploración y descripción de normatividad, legislación comparada y demás documentación pertinente. Posteriormente, se empleará un método analítico para contrastar la información recopilada y establecer una posición sobre el tema, generando así, conocimientos innovadores y útiles. Resultados: En ese orden, se revisó la trayectoria que ha experimentado arbitraje en materia fiscal dentro de la legislación ecuatoriana. Además, se analizaron los condicionantes tanto formales (legales) como informales que tradicionalmente se han esgrimido para vetar su establecimiento. A continuación, se reseñó la experiencia internacional de países como Portugal, Venezuela y Colombia; y se identificaron los aspectos que contribuyeron a sus respectivos éxitos y fracasos. Conclusión: De todo aquello se coligue que no hay impedimentos de orden legal ni constitucional para el arbitraje tributario. Además, el modelo portugués puede constituirse en un referente válido para sentar las bases de la institución en el país. Sin embargo, se advierte que su aparejamiento al objeto o ámbito de aplicación previsto por la Ley para la transacción o mediación devendría en perjuicio de su impacto. Área de estudio general: Derecho. Área de estudio específica: Derecho Tributario.
The Effectiveness of Psychoeducation on Depression Literacy and Psychological Well-being of University Students
Authors: Rathi Sayema Rahman , Prince Md Abu Hurayra , Baroi Bijon , Hossan Md Rony , Roy Kishor , Muhammad Noor 
Published: February 2024

Today’s modern life is a challenging issue for human beings, particularly those who have mental illnesses like depression, requiring awareness-related programs for increasing their Depression Literacy (D-Lit) and Psychological Well-being (PWB). To mark the gap, we planned to investigate the effect of web-based psychoeducation on literacy regarding depression and psychological well-being. A total of 100 depressed students were included in the sampling frame, purposively selected based on some inclusion and exclusion criteria from Jagannath University. The study was accomplished by following a pretest-posttest with a control group design where data were collected using Depression, Depression Literacy (D-Lit), and Psychological Well-being questionnaires along with a personal information form. The data were analyzed by applying an independent sample t-test, paired sample t-test, and ANCOVA. Results revealed that the level of D-Lit and PWB of the depressed students significantly increased in the post-test as compared to the pre-test in the experimental group, but no significant changes in the control group, indicating psychoeducation has an effect on increasing D-Lit and PWB. This finding explored that psychoeducation can be an immediate awareness program for improving depression-related knowledge and psychological well-being in the community. The applications of these outcomes for investigation and practice are discussed.
Jagannath University Journal of Science, Volume 10, Number I, Jun 2023, pp. 1−10
Possibility and Optimized Conditions for Spontaneous Superlattice Formation in Stabilized Zirconia Thin Films Grown Under In Situ Magnetic Field
Authors: Debnath Nipa , Das Harinarayan , Kumasaka Wataru , Kawaguchi Takahiko , Sakamoto Naonori , Shinozaki Kazuo , Suzuki Hisao , Wakiya Naoki 
Published: February 2024

A specially designed, named Dynamic Aurora pulsed laser deposition (PLD) has been developed to in situ grow thin films in a magnetic field up to 2000 G. Spontaneous superlattice formation occurs in the case of perovskite structure ceramics due to the application of magnetic field during thin films deposition. In this study, we examine the possibility and optimize the conditions of spontaneous superlattice formation in the case of fluorite structure, stabilized zirconia thin films under in situ magnetic field grown by Dynamic Aurora PLD. Although, a superlattice structure was not formed in this fluorite material system. To explain this discrepancy, several factors can be considered such as the number of the cation sites in the crystal structure. Perovskite structure has two cation sites, while the fluorite structure has only one cation site. This study provides necessary information for further research in developing self-organized superlattice structure synthesis techniques under magnetic-field associated pulsed laser deposition technique and simultaneously, also can play important roles in the processing of another materials system.
Jagannath University Journal of Science, Volume 10, Number I, Jun. 2023, pp. 55-63
Gut resistome profiling reveals high diversity and fluctuations in pancreatic cancer cohorts
Authors: Liu Xudong , Li Kexin , Yang Yun , Cao Dingyan , Xu Xinjie , He Zilong , Wu Wenming 
Published: February 2024

BackgroundPancreatic cancer is one of the deadliest cancer, with a 5-year overall survival rate of 11%. Unfortunately, most patients are diagnosed with advanced stage by the time they present with symptoms. In the past decade, microbiome studies have explored the association of pancreatic cancer with the human oral and gut microbiomes. However, the gut microbial antibiotic resistance genes profiling of pancreatic cancer patients was never reported compared to that of the healthy cohort.ResultsIn this study, we addressed the gut microbial antibiotic resistance genes profile using the metagenomic data from two online public pancreatic cancer cohorts. We found a high degree of data concordance between the two cohorts, which can therefore be used for cross-sectional comparisons. Meanwhile, we used two strategies to predict antibiotic resistance genes and compared the advantages and disadvantages of these two approaches. We also constructed microbe-antibiotic resistance gene networks and found that most of the hub nodes in the networks were antibiotic resistance genes.ConclusionsIn summary, we describe the panorama of antibiotic resistance genes in the gut microbes of patients with pancreatic cancer. We hope that our study will provide new perspectives on treatment options for the disease.
Dance as a mental health therapy in the Metaverse: exploring the therapeutic potential of Dance Movement Therapy as a non-pharmacological treatment in the Metaverse
Authors: Radanliev Petar 
Published: February 2024

IntroductionThis study conducts a detailed qualitative review of Alternative Therapies for mental health and proposes a novel design for integrating Non-Pharmacological Interventions into the Metaverse Extended Reality environments.Aim/questionThis study investigates the potential of the Extended Reality environments for Non-Pharmacological Interventions in Mental Health, with a specific focus on Dance Movement Therapy as a preventive and therapeutic strategy for anxiety, depression, and other mental health conditions.MethodThis study conducts qualitative evidence syntheses of primary quantitative data and performs meta-analyses of existing studies of participants reporting anxiety, depression, or other mental health conditions.ResultsDance Movement Therapy in the extended reality environments shows promise as a viable alternative therapy, but data privacy and ethical considerations must be addressed.DiscussionThis study raises significant concerns regarding the privacy and security of participants' data, necessitating the storage of only the metadata in electronically compatible files, in cases where users' data is stored for long-term preservation.Implications for practiceThe outcomes of this study could revolutionize mental health practice, providing effective Non-Pharmacological Interventions for anxiety, depression, and other mental health conditions.
Veno-arterial extracorporeal membrane oxygenation for respiratory and cardiac support in neonates: a single center experience
Authors: Wang Gang , Li Qiuping , Zhou Gengxu , Hong Xiaoyang , Zhao Zhe , Meng Qiang , Feng Zhichun 
Published: February 2024

ObjectiveExtracorporeal membrane oxygenation (ECMO) is an advanced life support that has been utilized in the neonate for refractory respiratory and circulatory failure. Striving for the best outcomes and understanding optimal surgical techniques continue to be at the forefront of discussion and research. This study presents a single-center experience of cervically cannulated neonatal patients on V-A ECMO, a description of our cannulation/decannulation techniques and our patient outcomes.MethodsSingle center retrospective review of neonates who received neck V-A ECMO support from January 2012 to December 2022. The data and outcomes of the patients were retrospectively analyzed.ResultsA total of 78 neonates received V-A ECMO support. There were 66 patients that received ECMO for respiratory support, the other 12 patients that received ECMO for cardiac support. The median duration of ECMO support was 109 (32–293) hours for all patients. During ECMO support, 20 patients died and 5 patients discontinued treatment due to poor outcome or the cost. A total of 53 (68%) patients were successfully weaned from ECMO, but 3 of them died in the subsequent treatment. Overall 50 (64%) patients survived to hospital discharge. In this study, 48 patients were cannulated using the vessel sparing technique, the other 30 patients were cannulated using the ligation technique. We found no significant difference in the rates of normal cranial MRI at discharge between survivors with and without common carotid artery ligation.ConclusionWe achieved satisfactory outcomes of neonatal ECMO in 11-year experience. This study found no significant difference in early neuroimaging between survivors with and without common carotid artery ligation. The long-term neurological function of ECMO survivors warranted further follow-up and study.
A prospective randomized controlled trial to determine the safety and efficacy of extracorporeal shock waves therapy for primary prevention of subclinical cardiotoxicity in breast cancer patients without a cardiovascular risk treated with doxorubicin
Authors: Song Shinjeong , Woo Joohyun , Kim HyunGoo , Lee Jun Woo , Lim Woosung , Moon Byung-In , Kwon Kihwan 
Published: February 2024

BackgroundDoxorubicin is a highly effective anti-cancer drug that causes left ventricular (LV) dysfunction and induces late-onset cardiomyopathy. However, an effective and clinically applicable preventive treatment is yet to be discovered.ObjectiveCardiac-Extracorporeal shockwave therapy (C-ESWT) has been suggested to treat inflammatory and ischemic diseases and protect cardiomyocytes from doxorubicin-induced cardiomyopathy. This study aims to assess the safety and efficacy of C-ESWT in the prevention of subclinical cardiotoxicity.MethodsWe enrolled 64 breast cancer patients. C-ESWT group 33 patients were treated with our C-ESWT (200 shots/spot at 0.09 mJ/mm2 for 20 spots, 3 times every six weeks). The efficacy endpoints were the difference in left ventricular global longitudinal strain (LVGLS) change by 2D speckle tracking echocardiography and chemotherapy-related cardiac dysfunction (CTRCD). Echocardiography was performed on the baseline line and every 4 cycles of chemotherapy, followed by a follow-up 3,6 months after chemotherapy to compare the incidence of cardiomyopathy of subclinical LV dysfunction due to chemotherapy between the two groups.ResultsParticipants averaged 50 ± 9 years in age, 100% female. In the results of follow-up 6 months after the end of chemotherapy, there was a significant difference in delta LVGLS between the C-ESWT group and the control group (LVGLS; −1.1 ± 10.9% vs. −11.5 ± 11.6% p-value; &lt;0.001). A total of 23% (15 patients) of patients developed CTRCD (Control group; 13 vs. C-ESWT group; (2). C-ESWT was performed safely without any serious adverse events.ConclusionIn this prospective study, C-ESWT established efficacy in preventing subclinical cardiotoxicity, especially in breast cancer patients using doxorubicin chemotherapy, and the safety of C-ESWT.Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT05584163).
A novel serum m7G-harboring microRNA signature for cancer detection
Authors: Chen Yaxin , Xie Yufang , Bi Liyun , Ci Hang , Li Weimin , Liu Dan 
Published: February 2024

Background: Emerging evidence points to the exceptional importance and value of m7G alteration in the diagnosis and prognosis of cancers. Nonetheless, a biomarker for precise screening of various cancer types has not yet been developed based on serum m7G-harboring miRNAs.Methods: A total of 20,702 serum samples, covering 12 cancer types and consisting of 7,768 cancer samples and 12,934 cancer-free samples were used in this study. A m7G target miRNA diagnostic signature (m7G-miRDS) was established through the least absolute shrinkage and selection operator (LASSO) analyses in a training dataset (n = 10,351), and validated in a validation dataset (n = 10,351).Results: The m7G-miRDS model, a 12 m7G-target-miRNAs signature, demonstrated high accuracy and was qualified for cancer detection. In the training and validation cohort, the area under the curve (AUC) reached 0.974 (95% CI 0.971–0.977) and 0.972 (95% CI 0.969–0.975), respectively. The m7G-miRDS showed superior sensitivity in each cancer type and had a satisfactory AUC in identifying bladder cancer, lung cancer and esophageal cancer. Additionally, the diagnostic performance of m7G-miRDS was not interfered by the gender, age and benign disease.Conclusion: Our results greatly extended the value of serum circulating miRNAs and m7G in cancer detection, and provided a new direction and strategy for the development of novel biomarkers with high accuracy, low cost and less invasiveness for mass cancer screening, such as ncRNA modification.
Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma
Authors: Zhao Hua , Zhao Yu , Zhang Siyuan , Wang Zhe , Yu Wenwen , Dong Nan , Yang Xuena , Zhang Xiying , Sun Qian , Hao Xishan , Ren Xiubao 
Published: February 2024

BackgroundThe infiltration and activation of immune cells in the tumor microenvironment (TIME) affect the prognosis of patients with cancer. Tertiary lymphoid structure (TLS) formation favors tumour- infiltrating-lymphocyte (TIL) recruitment and is regarded as an important indicator of good prognosis associated with immunotherapy in patients with tumors. Chemotherapy is currently one of the most commonly used clinical treatment methods. However, there have been no clear report to explore the effects of different types of chemotherapy on TLS formation in the TIME. This study examined the effects of immunogenic cell death (ICD)-inducing chemotherapeutics on immune cells, high-endothelial venules (HEV), and TLSs in mouse melanomas.MethodsDoxorubicin (an ICD inducer), gemcitabine (non-ICD inducer), and a combination of the two drugs was delivered intra-peritoneally to B16F1-loaded C57BL/6 mice. The infiltration of immune cells into tumor tissues was evaluated using flow cytometry. HEV and TLS formation was assessed using immunohistochemistry and multiple fluorescent immunohistochemical staining.ResultsDoxorubicin alone, gemcitabine alone, and the two-drug combination all slowed tumor growth, with the combined treatment demonstrating a more pronounced effect. Compared with the control group, the doxorubicin group showed a higher infiltration of CD8+ T cells and tissue-resident memory T cells (TRM) and an increase in the secretion of interferon-γ, granzyme B, and perforin in CD8+ T subsets and activation of B cells and dendritic cells. Doxorubicin alone and in combination with gemcitabine decreased regulatory T cells in the TIME. Moreover, doxorubicin treatment promoted the formation of HEV and TLS. Doxorubicin treatment also upregulated the expression of programmed cell death protein (PD)-1 in CD8+ T cells and programmed cell death protein ligand (PD-L)1 in tumor cells.ConclusionsThese results indicate that doxorubicin with an ICD reaction promotes TLS formation and increases PD-1/PD-L1 expression in tumor tissues. The results demonstrate the development of a therapeutic avenue using combined immune checkpoint therapy.
Retinal response to systemic inflammation differs between sexes and neurons
Authors: Rodríguez-Ramírez Kristy T. , Norte-Muñoz María , Lucas-Ruiz Fernando , Gallego-Ortega Alejandro , Calzaferri Francesco , García-Bernal David , Martínez Carlos M. , Galindo-Romero Caridad , de los Ríos Cristóbal , Vidal-Sanz Manuel , Agudo-Barriuso Marta 
Published: February 2024

BackgroundNeurological dysfunction and glial activation are common in severe infections such as sepsis. There is a sexual dimorphism in the response to systemic inflammation in both patients and animal models, but there are few comparative studies. Here, we investigate the effect of systemic inflammation induced by intraperitoneal administration of lipopolysaccharide (LPS) on the retina of male and female mice and determine whether antagonism of the NLRP3 inflammasome and the extrinsic pathway of apoptosis have protective effects on the retina.MethodsA single intraperitoneal injection of LPS (5 mg/kg) was administered to two months old C57BL/6J male and female mice. Retinas were examined longitudinally in vivo using electroretinography and spectral domain optical coherence tomography. Retinal ganglion cell (RGC) survival and microglial activation were analysed in flat-mounts. Retinal extracts were used for flow cytometric analysis of CD45 and CD11b positive cells. Matched plasma and retinal levels of proinflammatory cytokines were measured by ELISA. Retinal function and RGC survival were assessed in animals treated with P2X7R and TNFR1 antagonists alone or in combination.ResultsIn LPS-treated animals of both sexes, there was transient retinal dysfunction, loss of vision-forming but not non-vision forming RGCs, retinal swelling, microglial activation, cell infiltration, and increases in TNF and IL-1β. Compared to females, males showed higher vision-forming RGC death, slower functional recovery, and overexpression of lymphotoxin alpha in their retinas. P2X7R and TNFR1 antagonism, alone or in combination, rescued vision-forming RGCs. P2X7R antagonism also rescued retinal function. Response to treatment was better in females than in males.ConclusionsSystemic LPS has neuronal and sex-specific adverse effects in the mouse retina, which are counteracted by targeting the NLRP3 inflammasome and the extrinsic pathway of apoptosis. Our results highlight the need to analyse males and females in preclinical studies of inflammatory diseases affecting the central nervous system
A comparative study of MassARRAY and GeneXpert assay in detecting rifampicin resistance in tuberculosis patients’ clinical specimens
Authors: Liang Ruixia , Li Jiankang , Zhao Yue , Qi Haoran , Bao Shengjuan , Wang Fen , Duan Hongfei , Huang Hairong 
Published: February 2024

ObjectivesMatrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has emerged as a potent tool for detecting drug resistance in tuberculosis (TB); however, concerns about its reliability have been raised. In this study, we assessed the reliability of MassARRAY (Sequenom, Inc.), which is a MALDI-TOF MS-based method, by comparing it to the well-established GeneXpert assay (Cepheid) as a reference method.MethodsA retrospective study was conducted using laboratory data retrieved from Henan Chest Hospital (Zhengzhou, China). To ensure a rigorous evaluation, we adopted a comprehensive assessment approach by integrating multiple outcomes of the Xpert assay across various specimen types.ResultsAmong the 170 enrolled TB cases, MassARRAY demonstrated significantly higher sensitivity (85.88%, 146 of 170) compared to the Xpert assay (76.62%, 118 of 154) in TB diagnosis (p &lt; 0.05). The concordance in detecting rifampicin resistance between MassARRAY and the combined outcomes of the Xpert assay was 90%, while it was 97.37% (37 of 38) among smear-positive cases and 89.06% (57 of 64) among culture-positive cases. When compared to the phenotypic susceptibility outcomes of the 12 included drugs, consistency rates of 81.8 to 93.9% were obtained, with 87.9% for multiple drug resistance (MDR) identification.ConclusionMassARRAY demonstrates high reliability in detecting rifampicin resistance, and these findings may offer a reasonable basis for extrapolation to other drugs included in the test panel.
Aminopeptidase O Protein mediates the association between Lachnospiraceae and appendicular lean mass
Authors: Gao Bingjun , Zhou Zhonghua , Chen Junfei , Zhang Shengling , Jin Shaobin , Yang Weiwei , Lei Yinghan , Wang Kunyao , Li Jinxu , Zhuang Yan 
Published: February 2024

ObjectiveInvestigating the causal relationship between Lachnospiraceae and Appendicular lean mass (ALM) and identifying and quantifying the role of Aminopeptidase O Protein (AOPEP) as a potential mediator.MethodsThe summary statistics data of gut microbiota composition from the largest available genome-wide association study (GWAS) meta-analysis conducted by the MiBioGen Consortium (n = 13,266). Appendicular lean mass data were obtained from the UK-Biobank (n = 450,243). We conducted bidirectional two-sample Mendelian randomization (MR) analysis using summary-level data from GWAS to investigate the causal relationship between Lachnospiraceae and ALM. Additionally, we employed a drug-targeted MR approach to assess the causal relationship between AOPEP and ALM. Finally, a two-step MR was employed to quantitatively estimate the proportion of the effect of Lachnospiraceae on ALM that is mediated by AOPEP. Cochran's Q statistic was used to quantify heterogeneity among instrumental variable estimates.ResultsIn the MR analysis, it was found that an increase in genetically predicted Lachnospiraceae [OR = 1.031, 95% CI (1.011–1.051), P = 0.002] is associated with an increase in ALM. There is no strong evidence to suggest that genetically predicted ALM has an impact on Lachnospiraceae genus [OR = 1.437, 95% CI (0.785–2.269), P = 0.239]. The proportion of genetically predicted Lachnospiraceae mediated by AOPEP was 34.2% [95% CI (1.3%−67.1%)].ConclusionOur research reveals that increasing Lachnospiraceae abundance in the gut can directly enhance limb muscle mass and concurrently suppress AOPEP, consequently mitigating limb muscle loss. This supports the potential therapeutic modulation of gut microbiota for sarcopenia. Interventions such as drug treatments or microbiota transplantation, aimed at elevating Lachnospiraceae abundance and AOPEP inhibition, synergistically improve sarcopenia in the elderly, thereby enhancing the overall quality of life for older individuals.