bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomass‐derived washable composites for accelerating the healing of infected wounds
Authors: Jiao Fuhang , Zhao Wei , Zhao Wenbo , Wang Yong , Deng Yuan , Chang Shulong , Sun Junlu , Lou Qing , Wang Lijun , Shan Chong‐Xin , Xiao Ying , Dong Lin 
Published: October 2023

AbstractAdvanced sustainable biomedical materials are urgently needed for clinical applications; however, developing biomedical materials with exceptional mechanical and bactericidal properties as well as removable functionalities to reduce unintended secondary injury remains a challenge. Here, we report a biomass‐derived composite consisting of water‐soluble fish gelatin (FG) and antibacterial ZnO@silk fibroin (ZSF) microspheres for potential application as the wound dressing. The ZSF microspheres are embedded in a FG matrix to realize the stretchable, antibacterial, and removable ZSF/FG composites. By introducing glycerin as the plasticizer, ZSF/FG composites deliver a tensile strength of 4.5 MPa and stretchability of 550%. Acting as both the germicide and hydrophile components, ZSF microspheres endow the composites with excellent antibacterial capacity and water solubility. To prevent secondary injury, the ZSF/FG composites can be easily removed from the wounds by simply exposing them to excess water. Additionally, the ZSF/FG composites exhibit favorable biocompatibility and sustain high cell viability of over 100%. The full‐thickness skin wound model on infected mice demonstrated an efficient rate of wound closure and a reduced inflammatory response. The ZSF/FG composite shows promise to hasten the healing of infected wounds and is expected a promising candidate as wound dressing for clinical therapy.
L‐F001, a multifunctional fasudil–lipoic acid dimer, antagonizes hypoxic–ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway
Authors: Zhou Ruiyu , Wu Liqiang , Jin Ni , Sha Sha , Ouyang Ying 
Published: October 2023

AbstractIntroductionNeonatal hypoxic–ischemic brain damage (HIBD) is a serious inflammatory injury. At present, the standard treatment for this disease is hypothermia therapy, and the effect of drug intervention is still limited. L‐F001 is a compound of fasudil and lipoic acid. Previous in vitro experiments have confirmed that L‐F001 has anti‐inflammatory neuroprotective functions. However, its therapeutic effect on neonates with HIBD remains unknown. This study was aimed at exploring the therapeutic effect of L‐F001 on HIBD rats.MethodsThe newborn rats were divided into three groups: Sham operation group, HIBD group, and HIBD + L‐F001 group. HE staining, Nissil staining, the immunofluorescence of iNOS and COX‐2, ELISA (IL‐1β, IL‐6, TNF‐α, and IL‐10), and western blotting analyses were performed to determine the therapeutic effect of L‐F001. Finally, we evaluated the growth and development of each group by measuring body weight.ResultsThe hippocampal structure of HIBD rats was disordered, and the Nissil body was small and shallow. The expressions of iNOS and COX‐2 in HIBD rats were increased, whereas the expressions of IL‐1β, IL‐6, and TNF‐α in plasma were upregulated, and the expression of IL‐10 was decreased. L‐F001 could improve the tissue structure and reduce the expression of iNOS and COX‐2 in HIBD rats. Meanwhile, L‐F001 could also reduce the expression of pro‐inflammatory cytokines and restore the content of anti‐inflammatory cytokines in plasma. We further found that the TLR4 pathway was activated after hypoxic‐ischemia in neonatal rats. L‐F001 could inhibit the activation of TLR4 pathway. Finally, we found that after L‐F001 treatment, the body weight of HIBD rats increased significantly compared with the untreated group.ConclusionsL‐F001 antagonizes the inflammatory response after hypoxic‐ischemia by inhibiting the activation of the TLR4 signaling pathway, thus playing a neuroprotective role. L‐F001 may be a potential therapeutic agent for neonatal HIBD.
A flower‐like VO2(B)/V2CTx heterojunction as high kinetic rechargeable anode for sodium‐ion batteries
Authors: Jin Xiaoyu , Huang Yongxin , Zhang Mengmeng , Wang Ziheng , Meng Qianqian , Song Zhihang , Li Li , Wu Feng , Chen Renjie 
Published: October 2023

AbstractVO2(B) is considered as a promising anode material for the next‐generation sodium‐ion batteries (SIBs) due to its accessible raw materials and considerable theoretical capacity. However, the VO2(B) electrode has inherent defects such as low conductivity and serious volume expansion, which hinder their practical application. Herein, a flower‐like VO2(B)/V2CTx (VO@VC) heterojunction was prepared by a simple hydrothermal synthesis method with in situ growth. The flower‐like structure composed of thin nanosheets alleviates the volume expansion, as well as the rapid Na+ transport pathways are built by the heterojunction structure, resulting in long‐term cycling stability and superior rate performance. At a current density of 100 mA g−1, VO@VC anode can maintain a specific capacity of 276 mAh g−1 with an average coulombic efficiency of 98.7% after 100 cycles. Additionally, even at a current density of 2 A g−1, the VO@VC anode still exhibited a capacity of 132.9 mAh g−1 for 1000 cycles. The enhanced reaction kinetics can be attributed to the fast Na+ adsorption and storage at interfaces, which has been confirmed by the experimental and theoretical methods. These results demonstrate that the tailored nanoarchitecture design and additional surface engineering are effective strategies for optimizing vanadium‐based anode.
Lithium‐based batteries, history, current status, challenges, and future perspectives
Authors: Wulandari Triana , Fawcett Derek , Majumder Subhasish B. , Poinern Gerrard E. J. 
Published: October 2023

AbstractCurrently, the main drivers for developing Li‐ion batteries for efficient energy applications include energy density, cost, calendar life, and safety. The high energy/capacity anodes and cathodes needed for these applications are hindered by challenges like: (1) aging and degradation; (2) improved safety; (3) material costs, and (4) recyclability. The present review begins by summarising the progress made from early Li‐metal anode‐based batteries to current commercial Li‐ion batteries. Then discusses the recent progress made in studying and developing various types of novel materials for both anode and cathode electrodes, as well the various types of electrolytes and separator materials developed specifically for Li‐ion battery operation. Battery management, handling, and safety are also discussed at length. Also, as a consequence of the exponential growth in the production of Li‐ion batteries over the last 10 years, the review identifies the challenge of dealing with the ever‐increasing quantities of spent batteries. The review further identifies the economic value of metals like Co and Ni contained within the batteries and the extremely large numbers of batteries produced to date and the extremely large volumes that are expected to be manufactured in the next 10 years. Thus, highlighting the need to develop effective recycling strategies to reduce the levels of mining for raw materials and prevention of harmful products from entering the environment through landfill disposal.
Mechanochemical coupling of MGF mediates periodontal regeneration
Authors: Zhao Ying , Zhang Songbai , Cheng Bo , Feng Fan , Zhu Yue , Liu Yanli , Wang Junjun , Zou Dehui , Ma Heng , Xu Feng , Zhang Min 
Published: October 2023

AbstractClinical evidence shows that the mechanical stimulation obtained from occlusion could enhance periodontal ligament (PDL) remodeling. Mechano‐growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration. In vivo study found that MGF produced from the PDL under occlusion force could strongly enhance PDL remodeling. In vitro experiments and mathematical modeling further confirmed the mechanical enhancement effect of MGF for PDLSC differentiation toward fibroblasts. A mechanochemical coupling effect of MGF mediated the enhancement of mechanical effect, which was modulated by Fyn‐FAK kinases signaling and subsequent MAPK pathway. Finally, enhanced PDL regeneration under the mechanochemical coupling of MGF and occlusal force was verified in vivo. There exists an additive mechanical effect of MGF mediated by Fyn‐FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation, which could be developed as an MGF‐centered adjuvant treatment to optimize PDL remodeling, especially for patients with weakened bite force or destroyed periodontium.
Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins
Authors: Radhakrishnan Harikrishnan , Newmyer Sherri L. , Ssemadaali Marvin A. , Javitz Harold S. , Bhatnagar Parijat 
Published: October 2023

AbstractPrimary T cell has been transformed into a cell‐based delivery platform that synthesizes complex biologics at the disease site with spatiotemporal resolution. This broadly applicable technology can circumvent toxicities due to systemic administration of biologics that necessitates the use of high doses and may diffuse to the healthy tissues. Its clinical translation, however, has been impeded by manufacturing bottlenecks. In this work, a range of process parameters were investigated for increasing the production yield of the primary T cells engineered for delivery function. Compared to the common spinoculation‐based method, the transduction yield was enhanced ~2.5‐fold by restricting the transduction reaction volume for maximizing the lentivector‐to‐T‐cell contact. Cell density and cytokines used in the expansion process were adjusted to achieve >100‐fold expansion of the T‐cell‐based delivery platform in 14 days, and the function of these cells was validated in vivo using intraperitoneally implanted tumor cells. The primary T‐cell‐based delivery platform has human applications because it can be scaled and administrated to express a broad range of therapeutic proteins (e.g., cytokines, interferons, enzymes, agonists, and antagonists) at the disease site, obviating the need for systemic delivery of large doses of these proteins.
Getting away from death fear: How disease threat drives consumers' colorfulness seeking
Authors: Yi Yanxi , Luo Zhiwei , Wang Wangshuai , Li Jie , Han Bing 
Published: October 2023

AbstractThe COVID‐19 pandemic had significant effects on the health and wellbeing of people worldwide. However, in the post‐epidemic era, we still know very little about how disease threat shapes consumer psychology and behavior. To fill this gap in knowledge, the present study explores the effect of disease threat on a particular sensory preference of consumers, that is, a preference for colorfulness. Based on compensatory consumption theory, we propose the following: (1) consumers prefer colorful products and brand logos to compensate for both disease threat and chronically perceived disease threat; (2) the underlying mechanism for this effect is death‐related thoughts, in that disease threat leads to more death‐related thoughts, which in turn enhance colorfulness seeking; (3) the impact of disease threat on consumers' colorfulness seeking diminishes among high sensation seekers. A set of four studies, adopting both lab and survey methods, using various manipulations and measures, and testing diverse samples, provide convergent evidence for these hypotheses. Moreover, six alternative explanations were ruled out to further elucidate the psychological process under examination in this study. This paper contributes to the literature on consumer behavior, sensory marketing, terror management theory, and compensatory consumption. Implications of these findings are discussed.
Biological Properties of Cyclitols and Their Derivatives
Authors: Şimşek Kuş Nermin 
Published: October 2023

AbstractCyclitols are polyhydroxy cycloalkanes, each containing at least three hydroxyls attached to a different ring carbon atom. The most important cyclitol derivatives are inositols, quercitols, conduritols and pinitols, which form a group of naturally occurring polyhydric alcohols and are widely found in plants. In addition, synthetic production of cyclitols has gained importance in recent years. Cylitols are molecules synthesized in plants as a precaution against salt or water stress. They have important functions in cell functioning as they exhibit important properties such as membrane biogenesis, ion channel physiology, signal transduction, osmoregulation, phosphate storage, cell wall formation and antioxidant activity. The biological activities of these very important molecules, obtained both synthetically and from the extraction of plants, are described in this review.
Transition from secukinumab to adalimumab in COVID‐19‐induced psoriasis flare‐up treatment: A case report
Authors: Chen Yuting , Qiu Yangyang , Chen Meiqing , Huang Ling , Lin Xinyu , Qiu Xiaoyan , Wei Yi , Gao Lujuan 
Published: October 2023

Key Clinical MessageCoronavirus disease 2019 (COVID‐19) is known to trigger systemic inflammation and elicit immune responses, which may disrupt the delicate balance of cytokines involved in psoriatic regulation. Compared to other therapies in dermatology, biologics used for immune‐mediated dermatological diseases have been more extensively studied during the COVID‐19 pandemic. Herein, we report a case of flare‐up of previously well‐controlled psoriasis shortly after infection with COVID‐19, with treatment transition from secukinumab to adalimumab.
Development of robust chiroptical systems through spirobifluorenes
Authors: Portela‐Pino Julia , Talavera María , Chiussi Stefano , Bolaño Sandra , Peña‐Gallego Ángeles , Alonso‐Gómez J. Lorenzo 
Published: October 2023

AbstractChiroptical responses are valuable for the structural determination of dissymmetric molecules. However, the development of everyday applications based on chiroptical systems is yet to come. We have been earlier using axially chiral allenes for the construction of linear, cyclic, and cage‐shaped molecules that present remarkable chiroptical responses. Additionally, we have developed chiral surfaces through upstanding chiral architectures. Since the goal is to obtain robust chiroptical materials, more recently we have been studying spirobifluorenes (SBFs), a well‐established building block in optoelectronic applications. After theoretical and experimental demonstration, the suitability of chiral SBFs for the development of robust chiroptical systems was certified by the construction all‐carbon double helices, flexible shape‐persistent macrocycles, chiral frameworks for surface functionalization, and structures featuring helical or spiroconjugated molecular orbitals. Here, we give an overview of our contribution to these matters.
Clinical outcomes of combined catheter ablation and left atrial appendage closure in elderly patients with nonvalvular atrial fibrillation
Authors: Fei Xiaohong , Wang Binhao , Chu Huimin , Fu Guohua , Yu Yibo , Feng Mingjun , Du Xianfeng , Liu Jing 
Published: October 2023

AbstractBackgroundCatheter ablation (CA) combined with left atrial appendage closure (LAAC) has emerged as a promising method to relieve symptoms while reducing the incidence of stroke in selected high‐risk patients with atrial fibrillation (AF).HypothesisWe aimed to investigate the clinical outcomes of combined CA and LAAC in elderly patients.MethodsA total of 316 patients with symptomatic drug‐refractory AF who underwent combined CA and LAAC between January 2016 and December 2020 were retrospectively included. Baseline characteristics, periprocedural complications, and clinical events during follow‐up were recorded and compared between patients aged ≥ 75 years (n = 66) and <75 years (n = 250).ResultsPulmonary vein isolation and satisfactory LAAC were achieved in all patients. No patients experienced death or stroke/transient ischemic stroke periprocedurally. After a median follow‐up of 12.2 (6.7−24.4) months and 11.9 (5.5−23.6) months, the rate of sinus rhythm maintenance was comparable between the two groups (≥75 years: 78.8% vs. <75 years: 80.8%; log‐rank test, p = 0.674). The median follow‐up periods for clinical outcomes were 27.9 (9.3−44.8) months and 25.2 (10.8−45.7) months, respectively. In patients aged ≥ 75 years, one suffered ischemic stroke, and one experienced major bleeding event. In patients aged < 75 years, four had ischemic stroke, and eight had major bleeding events. Two patients aged < 75 years died during follow‐up, while none of the patients aged ≥ 75 years died.ConclusionsCombining CA and LAAC was feasible, safe and effective in elderly patients with AF.
An improved brain storm optimization with chunking‐grouping method
Authors: Guo Jinglei , Gao Chen , Jiang Shouyong , Xie Wei , Wu Zhijian 
Published: October 2023

SummaryBrain storm optimization (BSO) is a population‐based intelligence algorithm for optimization problems, which has attracted researchers' growing attention due to its simplicity and efficiency. An improved BSO, called CIBSO, is presented in this article. First of all, a new grouping method, in which the population is partitioned into chunks according to the fitness and recombined to groups, is developed to balance each group with same quality‐level. Afterwards, a new mutation strategy is designed in CIBSO and a learning mechanism is used to adaptively select appropriate strategy. Experiments on the CEC2014 test suite indicate that CIBSO is better or at least competitive performance against the compared BSO variants.
Oral healthcare providers play a vital role in vaccination efforts: Patient perspectives
Authors: Steinbaum Sara , Jagannath Julia , Seymour Lake , Corby Patricia , Kulkarni Roopali , France Katherine 
Published: October 2023

AbstractObjectivesHuman papillomavirus (HPV) is associated with 70% of oropharyngeal squamous cell carcinomas. Coronavirus disease 2019 (COVID‐19) is the infectious cause of a global pandemic that killed millions worldwide. Effective vaccinations exist against both diseases, but patient acceptance remains a challenge. The objective of this study was to assess patients' attitudes toward oral healthcare providers' (OHCPs) roles in HPV and COVID‐19 vaccinations.MethodsA cross‐sectional survey of young adult patients was distributed in Philadelphia, PA, between April and June 2021. The survey assessed knowledge and attitudes around OHCPs serving various roles in COVID‐19 and HPV vaccination.ResultsNearly 70% of 163 respondents would accept the recommendation for a COVID‐19 vaccine from an OHCP, while 56% would for HPV. Those previously vaccinated against COVID‐19 were more comfortable discussing COVID‐19 vaccines (92%, p < .001) or HPV vaccines (76%, p < .001) with OHCPs compared to those who were unvaccinated against COVID‐19. African American/Black patients were less comfortable discussing vaccines, irrespective of vaccination status.ConclusionsOHCP can play a vital role in increasing the overall COVID‐19 and HPV vaccination status of the public, as demonstrated by the high acceptance of dental involvement in both vaccine campaigns. Racial disparity in vaccination attitude is a public health challenge that needs to be addressed.
Socially responsible portfolios,environmental, social, corporate governance (ESG)efficient frontiers, and psychic dividends
Authors: Useche Alejandro J. , Martínez‐Ferrero Jennifer , Alayón‐Gonzales José Luis 
Published: October 2023

AbstractThe aim of this article is to evaluate the performance of investment portfolios built under environmental, social, and corporate governance (ESG) criteria or socially responsible portfolios, based on companies listed on three representative stock exchanges in Latin America (Chile, Colombia, and Peru) for the period 2011–2019. The performance of portfolios comprising high‐ESG stocks was compared with that of low‐ESG performance portfolios and with portfolios of companies that did not report such information, as well as against the main index of each market. A novel utility function was defined that allows evaluating different degrees of propensity to responsible investment, based on which restricted optimization processes were conducted to build efficient frontiers that combine traditional mean–variance aspects with ESG elements. Based on these frontiers, a measure of the psychic dividend or ESG utility premium generated by investing in high‐ESG portfolios is proposed. Results obtained in risk and return rates and Jensen, Treynor, alpha, VaR, tracking error, information coefficient, efficient frontiers, and utility premium show the value of following responsible investment criteria and the clear disadvantages in investing in companies that do not report ESG information. This research contributes to the debate on the importance of socially responsible investment guided by ESG criteria, filling a gap in the literature regarding Latin America and confirming the better performance by calculating a wide range of portfolio evaluation indicators. We proposed a novel approach to optimization with sustainability constraints, incorporating the utility premium derived from investing in stocks with better ESG performance.
Advance of microfluidic flow cytometry enabling high‐throughput characterization of single‐cell electrical and structural properties
Authors: Huang Xukun , Chen Xiao , Tan Huiwen , Wang Minruihong , Li Yimin , Wei Yuanchen , Zhang Jie , Chen Deyong , Wang Junbo , Li Yueying , Chen Jian 
Published: October 2023

AbstractThis paper reported a micro flow cytometer capable of high‐throughput characterization of single‐cell electrical and structural features based on constrictional microchannels and deep neural networks. When single cells traveled through microchannels with constricted cross‐sectional areas, they effectively blocked concentrated electric field lines, producing large impedance variations. Meanwhile, the traveling cells were confined within the cross‐sectional areas of the constrictional microchannels, enabling the capture of high‐quality images without losing focuses. Then single‐cell features from impedance profiles and optical images were extracted from customized recurrent and convolution networks (RNN and CNN), which were further fused for cell‐type classification based on support vector machines (SVM). As a demonstration, two leukemia cell lines (e.g., HL60 vs. Jurkat) were analyzed, producing high‐classification accuracies of 99.3% based on electrical features extracted from Long Short‐Term Memory (LSTM) of RNN, 96.7% based on structural features extracted from Resnet18 of CNN and 100.0% based on combined features enabled by SVM. The microfluidic flow cytometry developed in this study may provide a new perspective for the field of single‐cell analysis.
Fulminant type 1 diabetes: Focusing on triggering factors
Authors: Qiu Junlin , Yin Wenfeng , Wang Rui , Luo Shuoming , Zhou Zhiguang 
Published: October 2023

AbstractFulminant type 1 diabetes (FT1D) is a novel type of type 1 diabetes that is caused by extremely rapid destruction of the pancreatic β cells. Early diagnosis or prediction of FT1D is critical for the prevention or timely treatment of diabetes ketoacidosis, which can be life‐threatening. Understanding its triggers or promoting factors plays an important role in the prevention and treatment of FT1D. In this review, we summarised the various triggering factors of FT1D, including susceptibility genes, immunological factors (cellular and humoural immunity), immune checkpoint inhibitor therapies, drug reactions with eosinophilia and systemic symptoms or drug‐induced hypersensitivity syndrome, pregnancy, viral infections, and vaccine inoculation. This review provides the basis for future research into the pathogenetic mechanisms that regulate FT1D development and progression to further improve the prognosis and clinical management of patients with FT1D.