bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential correlations between asymmetric disruption of functional connectivity and metabolism in major depression disorder
Authors: Yang Yu , Ye Haibiao , Yan Haohao , Zhang Chunguo , Li Wenxuan , Li Zhijian , Liang Jiaquan , Li Xiaoling , Xie Guojun , Ou Yangpan , Li Xuesong , Guo Wenbin 
Published: November 2023

Abstract
Objective: Previous research has suggested a connection between major depressive disorder (MDD) and certain comorbidities, including gastrointestinal issues, thyroid dysfunctions, and glycolipid metabolism abnormalities. However, the relationships between these factors and asymmetrical alterations in functional connectivity (FC) in adults with MDD remain unclear.
Method: We conducted a study on a cohort of 42 MDD patients and 42 healthy controls (HCs). Participants underwent comprehensive clinical assessments, including evaluations of blood lipids and thyroid hormonelevels, as well as resting-state functional magnetic resonance imaging (Rs-fMRI) scans. Data analysis involved correlation analysis to compute the parameter of asymmetry (PAS) for the entire brain's functional connectome. We then examined the interrelationships between abnormal PAS regions in the brain, thyroid hormone levels, and blood lipid levels.
Results: Thyroid-stimulating hormone (TSH) level was found to be significantly lower in MDD patients compared to HCs. The PAS score of the left inferior frontal gyrus (IFG) decreased, while the bilateral posterior cingulate cortex (Bi-PCC) PAS increased in MDD patients relative to HCs. Notably, the PAS score of the left IFG negatively correlated with both TSH and total CHOL levels, but this correlation became non-significant after the Bonferroni correction.
Conclusion: MDD patients demonstrated abnormal asymmetry in resting-state functional connectivity (Rs-FC) within the fronto-limbic system, which may be associated with blood lipids and thyroid hormone levels.
Development of Ranking for Sustainable Forest Management Criteria in Peninsular Malaysia by using the Method based on the Removal Effects of Criteria
Authors: Azman Anis Izzatie , Zaibidi Nerda , Nawawi Mohd Kamal Mohd 
Published: November 2023

Abstract
Peninsular Malaysia has approximately 13.22 million acres of land, with approximately 5.69 million acres forested throughout the state. The forests of peninsular Malaysia will also produce millions of cubic metres of logs, sawn timber, plywood, veneer, and moulding by 2021. Because the forest produces so many resources, it also causes a slew of issues, such as illegal logging and flash floods. SFM takes a holistic approach to ensuring that forest operations provide social, environmental, and economic benefits, that competing needs are balanced, and that forest functioning is preserved and improved today and in the future. The goal of this research is to rank the criteria for three critical dimensions: environmental, economic, and social, that will affect the level of sustainability of forest management in Peninsular Malaysia. This study employs the Method Based on the Removal Effects of Criteria (MEREC) to identify the objective weight and rank all the criteria. The result shows that there are three criteria that have a big impact on all dimensions and another three criteria may not be included since they have no impact on the respective dimensions. With all conclusions, it shows that MEREC is a consistent and reliable method to be considered.
Identification of a Macrophage Marker Gene Signature to Evaluate Immune Infiltration and Therapeutic Response in Hepatocellular Carcinoma Based on Single-cell and Bulk RNA Sequencing Data
Authors: Li Tong , Xu Xin , Nakayama Kiyoko , Ren Zhenggang , Zhang Lan 
Published: November 2023

Abstract
Background
Only a minority of hepatocellular carcinoma (HCC) patients can benefit from systemic regimens. Macrophages, which abundantly infiltrate in HCC, could mediate tumour microenvironment remodelling and immune escape, proving to be powerful weapons in combating HCC. Thus, a deeper understanding of macrophages is necessary for improving existing antitumour treatments.
Methods
By leveraging a series of bioinformatic and machine learning approaches, we comprehensively explored the transcriptomic landscape of human HCCs and the role of macrophages related genes in HCC from multiple single-cell and bulk RNA sequencing datasets. The uniform manifold approximation and projection (UMAP) was utilized for dimensionality reduction and the FindAllMarkers function was used to detecting for differentially expressed genes (DEGs). Unsupervised clustering was performed using the “ConsensusClusterPlus” to cluster the macrophage marker genes (MMGs). Further, Gene set variation analysis (GSVA) and Function Enrichment Analysis to elucidate the functional difference of the MMGs associated clusters. Subsequently, identified 12 hub genes, based on which component analysis algorithm (PCA) was employed to construct Macrosig score. Meanwhile, the prognosis, biological characteristics, mutation profile, TME cell-infiltrating and drug response of different Macrosig score were analysised.
Results
Our studies identified 13 macrophage marker genes (MMGs) based on 574 HCC samples, based on which three MMG-associated clusters(A,B,C) were defined. Patients in cluster B were significantly associated with favorable overall survival, clinicopathological features and a lower immune infiltration score. On this basis, 12 hub genes were identified among these clusters, subsequently a scoring system by principal component analysis was constructed terming the Macrosig score. Importantly, patients with low Macrosig score, characterized by higher immune infiltration, increased mutation frequency and higher immune checkpoint expression including CTLA-4, LAG3, PDCD1 and TIGIT, exhibiting enhanced efficacy of immunotherapy as expected when validated in external database. Moreover, for molecular targeted therapy, low Macrosig score indicates increased sensitivity to AZD.2281, A.443654, ABT.263, ABT.888, AG.014699 and ATRA, while high Macrosig score were more likely to be sensitive to AZD6482, AKT inhibitor VIII, AS601245, AZ628, AZD.0530 and AZD6244.
Conclusions
In summary, a novel scoring system based on macrophage subclusters was constructed, thereby guiding more effective prognostic evaluation and tailored therapeutic regimens of HCC patients.
Sustained attention operates via dissociable neural mechanisms across different eccentric locations
Authors: Phangwiwat Tanagrit , Punchongharn Phond , Wongsawat Yodchanan , Chatnuntawech Itthi , Wang Sisi , Chunharas Chaipat , Sprague Thomas , Woodman Geoffrey F. , Itthipuripat Sirawaj 
Published: November 2023

Abstract
In primates, foveal and peripheral vision have distinct neural architectures and functions. However, it has been debated if selective attention operates via the same or different neural mechanisms across eccentricities. We tested these alternative accounts by examining the effects of selective attention on the steady-state visually evoked potential (SSVEP) and the fronto-parietal signal measured via EEG from human subjects performing a sustained visuospatial attention task. With a negligible level of eye movements, both SSVEP and SND exhibited the heterogeneous patterns of attentional modulations across eccentricities. Specifically, the attentional modulations of these signals peaked at the parafoveal locations and such modulations wore off as visual stimuli appeared closer to the fovea or further away towards the periphery. However, with a relatively higher level of eye movements, the heterogeneous patterns of attentional modulations of these neural signals were less robust. These data demonstrate that the top-down influence of covert visuospatial attention on early sensory processing in human cortex depends on eccentricity and the level of saccadic responses. Taken together, the results suggest that sustained visuospatial attention operates differently across different eccentric locations, providing new understanding of how attention augments sensory representations regardless of where the attended stimulus appears.
Neural basis responsible for emotion regulation association with procrastination: Right dlPFC functional connectivity with left insula
Authors: Li Keli , Zhang Rong , Feng Tingyong 
Published: November 2023

Abstract
Procrastination, an irrational delay of intended action, leads to numerous adverse effects in many life domains, such as low academic performance, poor mental health and financial distress. Previous studies have revealed a substantial negative correlation between emotional regulation and procrastination. However, it still remains unclear about the neural basis for the association between emotion regulation and procrastination. Therefore, we employed the voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) methods to explore the neural substrates underlying how emotion regulation responsible for procrastination (N = 243). In line with our hypothesis, the results showed a strong negative correlation between emotion regulation and procrastination (r =-0.39). The VBM analysis showed that emotion regulation was positively correlated with gray matter (GM) volumes in the right dorsal-lateral prefrontal cortex (dlPFC). Next, the RSFC results indicated that dlPFC-insula functional connectivity was positively associated with emotion regulation. Furthermore, the mediation analysis showed that emotion regulation mediated the relationship between the dlPFC-insula functional connectivity and procrastination. The current findings suggest that the neural pathway related to cognitive control over aversive emotion may responsible for the close relationship between emotion regulation and procrastination, which provides a novel perspective for explaining the tight association between emotion regulation and procrastination.
Anatomical evaluation of the nasolacrimal groove in 150 dry bones in the Anatolian population
Authors: CHATZIOGLOU Gkionoul NTELI , Önal Vildan , Gayretli Özcan 
Published: November 2023

Abstract
Pupose: In this study, we aimed to evaluate the anatomical features of the nasolacrimal groove in detail by providing a morphological classification based on morphometric evaluations of the nasolacrimal groove. Methods: A total of 150 sagittal dry bones in the Department of Anatomy, Faculty of Medicine, Istanbul University were evaluated. The length and the width at different points of the nasolacrimal canal were calculated. According to the widths of the nasolacrimal canal 10 different morphological types were revealed. Results: The length of the canal was found as mean 13.62 ± 2.42 mm on the right and 12.44 ± 2.68 mm on the left side. The entrance, the base, the upper and the lower thirds of nasolacrimal canal were 6.22 ± 1.19 mm, 7.95 ± 1.85 mm, 5.85 ± 1.06 mm, 6.60 ± 1.54 mm, on the right and 6.08 ± 1.16 mm, 7.24 ± 1.64 mm, 5.45 ± 1.29 mm, 6.23 ± 1.48 mm, on the left side, respectively. The width of the entrance of the nasolacrimal canal was the narrowest width compared to the base, upper and lower thirds in 7/10 types of 71/150 cranial bones. Conclusion: This comprehensive morphological classification of the nasolacrimal groove sheds new light on its complex variations. We support that the finding of this study has the potential to improve the precision of diagnostic assessments and guide specific therapeutic interventions for patients with lacrimal drainage disorders.
Investigation of pressure transients induced on a real water service line by user's activity
Authors: Marsili Valentina , Mazzoni Filippo , Alvisi Stefano , Maietta Filomena , Capponi Caterina , Meniconi Silvia , Brunone Bruno , Franchini Marco 
Published: November 2023

Abstract

Recent studies point out that water distribution networks can be affected by long- and short-term pressure oscillations due to the users' activity. However, these transients, generated at the household level, before reaching the water distribution network pass through, and thus affect, the water service line and can contribute to its deterioration. Despite the role of user-induced transients in stressing service lines, few studies in the literature explored the topic, exclusively by means of laboratory tests. The current study is aimed at exploring the effects of user's activity on a real service line starting from the field monitoring of pressure data at 500-Hz temporal resolution. Pressure signals are collected both when activating single water devices of the user supplied by the service line and during the ordinary use of domestic devices. The analyses of the acquired data highlight that the domestic service line is subjected to significant pressure variations (which can reach extreme values of −15 and +65 m) based on the device type and distance between the device and the service line and that the use of these devices can continuously stress the water service line.
Drug Delivery for Ocular Allergy: Current Formulation Design Strategies and
Future Perspectives
Authors: Regu Varaprasada Rao , Swain Ranjit Prasad , Subudhi Bharat Bhusan 
Published: November 2023

Abstract:
The incidences of ocular allergy have been growing with the increase in pollution. Because of challenges
in new drug development, there have been efforts to maximize the efficacy of existing drugs through
drug delivery approaches. The effectiveness of drugs in ophthalmic conditions is primarily determined by
permeability across the barrier, corneal retention, and sustained release. Thus, there have been widespread efforts
to optimize these parameters to enhance efficacy through novel formulations. This review aims to analyze
the approaches to drug delivery systems to encourage further research to optimize effectiveness. With this
objective, research on drug delivery aspects of anti-allergy therapeutics was included and analyzed based on
formulation/drug delivery technique, Food and Drug Administration approval limits, residence time, compatibility,
pre-clinical efficacy, and potential for translational application. Conventional eye drops have concerns
such as poor residence time and ocular bioavailability. The novel formulations have the potential to improve
residence and bioavailability. However, the use of preservatives and the lack of regulatory approval for polymers
limit the translational application. The review may assist readers in identifying novel drug delivery strategies
and their limitations for the development of effective ophthalmic formulations for the treatment of ocular
allergy.
Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children
Authors: Mohan Kriti , Omar Balram Ji , Chacham Swathi , Bharti Ajay 
Published: November 2023

:
There is evidence that few trace elements in the environment work as hazardous materials
in terms of their exposure in the perinatal period, causing autistic spectrum disorder (ASD) in
children, and avoiding these exposures in the environment can reduce the number of new cases.
This perspective study provides preliminary evidence to consider a few trace elements as culprits
for ASD. More studies with larger cohorts are needed, but meanwhile, as per available evidence,
exposure to these hazardous materials must be warranted during pregnancy and early stages of
life.
Detection of Abnormality in Coronary Artery Magnetic Resonance Imaging
using Bit Plane Slicing and Deep Learning
Authors: Lam Thuy Le Nhi , Hoang Trong Vo , Trung Hieu Huynh , Bao Pham The 
Published: November 2023

Introduction::
This paper presents a novel approach for detecting abnormality in coronary arteries using MRI data in RGB images. The study evaluates the test
accuracy of the weak classifiers and the test accuracy and F1 score of the strong classifier.

Methods::
The method involves separating the image into information planes, including R, G, and B color space, or bit-planes, and training a VGG-like
convolutional neural network model on each plane separately, referred to as a “weak classifier.” The classification results of these planes are
aggregated using a proposed soft voting method, forming a “strong classifier,” with the weights for the aggregation determined by the model's
performance on the training set.

Results::
The results indicate that the strong classifier achieves a test accuracy and F1 score of around 68% to 74% on our private coronary artery dataset.
Moreover, by aggregating the top three highest bit-plane levels in a grayscale image, the accuracy is slightly lower than that of the three color
spaces but requires a significantly smaller CNN model of nearly 4M parameters.

Conclusion::
The potential of bit-planes in reducing model storage costs is suggested. This approach holds promise for improving the detection of abnormalities
in coronary arteries using MRI data.
Investigating the Correlation between Liver Ultrasound pSWE and Portal Vein
Hemodynamics: Preliminary Findings
Authors: Sultan Salahaden R. , Abdeen Rawan 
Published: November 2023

Introduction::
Portal vein size and hemodynamics can be altered in patients with portal hypertension. Elastography for liver stiffness has been proposed as a
potential predictor of portal hypertension. However, the relationship between liver stiffness measured using point shear wave elastography (pSWE)
and portal vein diameter and Doppler parameters remains unclear. Therefore, this observational study aimed to investigate the correlation between
liver ultrasound pSWE and portal vein hemodynamics in healthy participants.

Methods::
Twenty-five healthy men with no underlying medical conditions and who were not on regular medications were enrolled in the study. Liver
stiffness, portal vein diameter, and Doppler parameters were measured using ultrasound EPIQ Elite with a curved-array transducer (C5-1 MHz)
equipped with pSWE and Doppler imaging. Real-time pSWE measurements were taken from the liver. Portal vein diameter and Doppler
parameters were measured in a longitudinal view of the extra-hepatic segment. Spearman correlation was used to assess the association between
liver pSWE and portal vein diameter as well as Doppler parameters, with a significance level set at < 0.05.

Results::
There was no significant correlation between liver stiffness and portal vein diameter (p = 0.67) or Doppler parameters, including peak systolic
velocity (p = 0.89), end-diastolic velocity (p = 0.65), and resistive index (p = 0.86).

Conclusion::
Our findings suggest no direct correlation between liver stiffness measured using pSWE and portal vein hemodynamics in healthy adults. Further
studies are warranted to investigate the relationship between liver pSWE and the hemodynamics of portal veins in patients with liver diseases.
The Performance of Marketing and Distribution on Supply Chain of Rice in Merauke Regency, Papua, Indonesia
Authors: Widyantari Ineke Nursih 
Published: November 2023

AbstractMerauke is projected to be the rice barn in Eastern part of Indonesia. Many programmes are implemented to improve rice production. This study was conducted to figure out the number of distribution channels for rice marketing, to find out the efficient rice marketing actor, to recognise the smooth flow of product, money, and information on distribution of rice supply chain. The study was carried out in Merauke, i.e., districts of Semangga and Tanah Miring. Rice traders were sampled using the snowball technique, the initial point of farmers with 239 respondents. The results showed that there were four distribution channels of rice in Merauke. The most efficient rice marketing actor was the rice mill selling its product to Bulog partners. The pattern of the distribution of rice supply chain describing the flow of product, money and information was basically smooth, however, there was an unsmooth part in details. Keywords:Distribution, Marketing, Rice, Supply Chain
Utilization of the Canva application on the Belajar.Id site as a learning media at SMK Bina Nusa Mandiri Jakarta
Authors: Putri Indira , Jumardi Jumardi 
Published: November 2023

This study aims to discover the use of the Canva Education Application as a learning medium accessed through web learning. id for teachers at SMK Bina Nusa Mandiri Jakarta. This research is a type of qualitative research with a literature study approach. Literature study qualitative research consists of 4 stages: making interview instruments, looking for reading material, recording, and analyzing research material obtained. The results of interviews conducted with teachers at SMK Bina Nusa Mandiri show that the Canva Education application is handy because it can help teachers create engaging learning media for students. The Canva Education application has various features teachers can use to create learning media, such as PPTs, learning videos, infographics, etc. The research results show that the Education Canva Application facilitated by the Ministry of Education and Culture allows teachers at Bina N`usa Mandiri Vocational School to create learning media using only the learn quickly. Id website and can already get the Canva Application for free. The meaning of using the Canva application on learning.id website for history teachers at Bina Nusa Mandiri Vocational School is to be an exciting learning medium because history lessons are famous for lessons that only focus on books. The Canva application learning media has various templates and can also be used to make history-learning videos look interesting. The Canva App can vary in history lessons.
Nonface-to-Face Visitation to Restrict Patient Visits for Infection Control: Integrative Review
Authors: Jeong Hyunwoo , Choi Yonsu , Kim Heejung 
Published: November 2023

Background
In the COVID-19 pandemic, a visit restriction policy for patients has been implemented in medical institutions worldwide and visits are being made using alternative communication technologies. This shift has also required the use of platforms to prevent negative consequences of these restrictions.

Objective
The purpose of this review was to comprehensively explore nonface-to-face visits as an alternative during infection prevention and to synthesize the scientific evidence of their benefits and disadvantages.

Methods
A comprehensive search was conducted via the PubMed, Embase, CINAHL, Cochrane, and Web of Science electronic databases; unpublished trials in the clinical trials register ClinicalTrials.gov; and Virginia Henderson International Nursing Library up to September 10, 2021. The search query was developed according to the guidelines of the Peer Review of Electronic Search Strategies and included keywords on the topics of telemedicine and visitation restrictions. The inclusion criteria were a nonface-to-face modality using telemedicine with family in a hospital setting, experimental and observational studies, and articles written in English. The exclusion criteria were inaccessible in full text, not related to patient or family involvement, mainly focused on the study protocol, or only discussing the pros and cons of telemedicine.

Results
Overall, patients’ families experienced emotional distress due to restrictions on face-to-face visits. Nonface-to-face virtual visits compensating for these restrictions had a positive effect on reducing the risk of infection to the patient and the family. This further encouraged psychological and physical recovery and decreased psychological distress. However, nonface-to-face virtual technology could not replace the existence of actual families, and technical problems with networks and devices are reported as limitations.

Conclusions
Ensuring the availability of technology and educating on the same in alignment with the characteristics of patients and their families, nonface-to-face virtual visits need to show more potential as an effective patient-centered treatment strategy based on more research and advanced practice.