bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to contraceptive utilization among Reproductive Age Women of Eritrean Refugee in North West Tigray, Ethiopia: a mixed study
Authors: Gebrehiwot Solomon Weldemariam , Abera Gedamu , Berhe Almaz , Zenebe Kahsay 
Published: January 2024

Abstract

Universal access to family planning could prevent nearly one-third of the estimated 300,000 maternal deaths. Contraceptive utilization is low in humanitarian settings. Currently, there is a dearth of information on the use of contraceptives among refugee women in many low-income countries including the study area. A community based cross sectional study with qualitative data was employed from January 1 to February 1, 2017. Systematic and purposive sampling techniques were applied. Data was entered to Epi Info version 3.3.2 and transported to SPSS version 20.0 software for analysis. Significance was declared at p-value of < 0.05. Odds ratio along with 95% confidence interval was computed to ascertain the strength of the association. Among the 532 respondents who experienced sex, 192(36.1%) were using contraceptive method. Exposure to media (AOR = 2.207, 95% CI = 1.244, 3.917), residence (AOR = 2.593, 95% CI = 1.513, 4.444), discussion on reproductive goals (AOR = 2.817, 95% CI = 1.681, 4.721) and longer duration stay in camp (AOR = .4.065, 95% CI = 1.845, 8.956, AOR = 2.200, 95% CI = 1.084, 4.466) were significant factors. Prevalence of contraceptive utilization in refugees was low. A lot of obstructing factors to access the service were identified in this study. This gap will intensify the existing maternal and child mortality dire in refugee settings.
Giant retroperitoneal hemolymphangioma: case report and literature review
Authors: Wang Yi-kai , Liu Ying-hao , Shuang Wei-bing 
Published: January 2024

Abstract
Hemolymphangioma is a very rare benign tumor in clinical practice caused by abnormalities of the vasculature. Here, we report a patient with a giant retroperitoneal hemolymphangioma. A 37-year-old man was admitted to the hospital because of unprovoked upper abdominal distension and low back pain. Computed tomography (CT) and magnetic resonance imaging (MRI) suggested the possibility of a giant retroperitoneal lymphatic cyst. The patient underwent surgical treatment after adequate drainage. The postoperative pathological diagnosis was retroperitoneal hemolymphangioma. Its clinical features are often atypical, and it is easy to miss and misdiagnose. When the time of nuclear magnetic T1 is significantly reduced, the diagnosis of hemangiangiangioma should be considered. Therefore, we report this case in the hope of raising clinicians' awareness of the disease.
Quantum privacy query protocol based on counterfactual quantum key distribution with noiseless attack
Authors: Liu Dongmei , Li Jian , Chen Xiubo , Ye Chongqiang , Wang Zhou 
Published: January 2024

Abstract

To save quantum resources and improve efficiency, this article proposes an efficient counterfactual quantum privacy query protocol. Counterfactual quantum privacy query refers to the identification of secure detection and key screening based on the detector's response results without the actual transmission of quantum information between user Bob and database Alice. Alice completes key transmission through a counterfactual device, while Bob measures the photon's polarization with a probability of 1/2 to obtain the encoded classical information, followed by traditional post-processing and privacy query operations. Additionally, to withstand the noise impact during the communication process, a modified counterfactual QKD protocol proposed by Rao (2021) is utilized, where communication parties randomly select a quantum bit flip with a specified probability \textit{f}, and then complete the quantum privacy query.
Assessment of natural mycorrhizal potential in Genista aspalathoïdes Lamk.: A case study in Djelfa, Algeria
Authors: Bouabdelli Zahra Robã , Guit Ibrahim , Malika Brahimi , Berkane Imane 
Published: January 2024

Abstract

Preliminary survey on the Arbuscular mycorrhizal fungal species composition in the rhizosphere of Genista aspalatoide Lamk subsp. erinaceoides (Lois.) Maire growing in the arid area present in South Algeria were studied. Roots and rhizosphiric soil from this species were analyzed. In this work, we proposed to evaluate the rate of mycorrhizal infection expressed by four parameters. The physical and chemical characteristics of soil were assessed through measurement of pH, electrical conductivity, organic matter, Active calcareous, total calcareous and texture. Spores of fungi harvested in the rhizospheric area were morphologically identified. The results showed that host plants harbored arbuscular mycorrhizal fungi (AMF), The average colonization by these AMFs showed that the frequency of mycorrhizal in the root system (F%) was reached 100%, intensity of colonization M (62.8%), arbuscular content of infection A (39.7%) and arbuscular abundance in mycorrhizal parts of root fragments a (28.4%). Study area characterized by alkaline soils, very low organic matter, and relatively low levels of calcium carbonates with a silt texture. 02 families of endomycorrhizae have been isolated (Glomeraceae and Acaulosporaceae) with a 4 genera Septoglomus, Glomus, rhizophagus and acaulospora.
Comparison of Bond Strength of Different Indirect Composite Systems and CAD/CAM Composite Blocks between Dentin and Composite Surfaces: An in vitro study
Authors: Batgerel Oyun Erdene , Yazıcıoğlu Oktay , Kıtın Emine , Gençel Burç İhsan , Yamak Fatih , Bozdağ Süreyya Ergün 
Published: January 2024

Abstract
This study aims to compare the shear bond strength of different indirect restorative materials bonded to the microhybrid composite and dentin surfaces. A total of 192 cylindrical specimens (3mm height, 3mm diameter) were prepared from GradiaPlus, GC(GRA); CeramageBody, Shofu(CER); TesceraATL, Bisco(TES); and Lava Ultimate, 3M Espe(LAV) materials. In addition, 48 newly extracted molars were embedded in acrylic resin 2 mm below the cementoenamel junction and sliced horizontally using a cutting device (IsoMet 1000; Buehler, USA) to form flat dentin surfaces. Using a specially customized 4x2mm disc-shaped mold, 48 disc-shaped composite surfaces were obtained with the Z250 Microhybrid composite (3M Espe, USA) material by layering technique. A total of 2 cylindrical indirect composite specimens were cemented to each disc-shaped composite and flat dentin surfaces. Samples obtained from indirect composite were divided into 16 groups in total, with two different subgroups luted with RelyX U200(RX-U200) self-adhesive cement (3M Espe, USA) and RelyX Ultimate(RX-ULT) clicker dual-cure cement (3M Espe, USA) to the dentin and microhybrid composite surfaces (n = 12). Groups are respectively: 1)GRA + Dentin + RX-U200 2)TES + Dentin + RX-U200 3)CER + Dentin + RX-U200 4)LAVA + Dentin + RX-U200 5)GRA + Composite + RX-U200 6)TES + Composite + RX-U200 7)CER + Composite + RX-U200 8)LAVA + Composite + RX-U200 9)GRA + Dentin + RX-ULT 10)TES + Dentin + RX-ULT 11)CER + Dentin + RX-ULT 12)LAVA + Dentin + RX-ULT 13)GRA + Composite + RX-ULT 14)TES + Composite + RX-ULT 15)CER + Composite + RX-ULT 16)LAVA + Composite + RX-ULT (n = 12). The Shear Test was carried out by applying 0-400 N loading and 1 mm/min force to each sample at Instron Universal Testing Machine. Light microscopy and SEM were used to examine the failure type. The results obtained in the study were evaluated by using ShapiroWilk's test, Mann-Whitney U test and Chi-Square test.(p < 0.05) Significantly higher bonding values were obtained in the specimens bonded to the surface of Z250 microhybrid composite (3M ESPE, USA) compared to the specimens bonded to the dentin surface (p < 0.001). When the shear strength of indirect restoration materials is compared; the highest value was measured in the CER + Composite + RX-ULT(Av:91.41Mpa) group, and the lowest value was measured in the LAVA + Dentin + RX-U200(Mean:35.96Mpa) group(p < 0.001). When the bond strengths of the cement systems were compared, RX-ULT dual-cure cement showed higher bond strength values than RX-U200 self-adhesive cement on both dentin and Z250 Microhybrid composite surface (p < 0.05).
Higher levels of impulsivity and depression are present in patients with temporal and extra- temporal focal epilepsy
Authors: Stivala Ernesto Gonzalez , Wolfzun Camila , Sarudiansky Mercedes , Kochen Silvia , Giagante Brenda , Oddo Silvia , Korman Guido , D´Alessio Luciana 
Published: January 2024

Abstract
Purpose: To analyze patients with clearly and defined focal epilepsy from temporal (ELT) and extra-temporal lobe origin (ETE), and a control group, and to compare the prevalence of psychiatric comorbid disorders and the levels of impulsivity between them.
Methods: Consecutive patients who met criteria of drug-resistant focal epilepsy of temporal and/or extra-temporal origin, clearly defined and confirmed by VEEG (Video-EEG), were included. Psychiatric assessment was conducted using the Structured Clinical Interview for Axis I and II diagnose of DSM-IV (SCID I-II), the Barrat-11 scale for measure impulsivity, and Beck inventory for depression.
Results: 73 patients with drug-resistant temporal lobe epilepsy (TLE), 21 with extra-temporal focal epilepsy (ETE) and 58 healthy control subjects were included. A total of 45 patients (61.6%) in TLE group and 13 patients (61.9%) in ETE group met criteria for at least one present or past psychiatry disorder coded on Axis I of DSM-IV. Both ELT and ETE groups presented higher Barrat-11 scores compared to the control group (p<0.01). ETE showed a tendency to a higher impulsivity level, particularly in the motor factor compared to ELT (p=0.05). A left laterality of the epileptogenic zone, and the presence of psychiatric disorders (depression) were associated with higher impulsivity among patients with ELT (p<0.05).
Conclusion: Impulsivity and psychiatric comorbidity are important issues to consider in clinical evaluation of patients with drug-resistant focal epilepsies. The evaluation by an adequately mental health team should be considered routine among these patients.
Enhancing the lab skills of Dental Students: A Blended Learning approach
Authors: Ahsan Areesha , Shafi Riffat , Sunny Adnan , Babar Sardar Waleed 
Published: January 2024

Abstract

BACKGROUND: Blended learning is a teaching methodology that is an amalgamation of face-to-face teaching and online teaching methods. Using blended learning of traditional live demonstrations and educational videos helps the students boost their skills further and gain confidence in the laboratory work. Shifa College of Dentistry follows an integrated curriculum. The removable partial denture sessions for the first and second-year students are mainly pre-clinical skill sessions in the Prosthodontic laboratory.AIMS: We aimed to evaluate the effectiveness of blended teaching and learning strategies for the skill sessions of Prosthodontics by providing the students with pre-reading materials along with instructional videos before the skill sessions. Scores of pre-test and post-test were analyzed. Student’s views were also collected regarding blended teaching methodology.METHODOLOGY: The study was conducted with second-year students at Shifa College of Dentistry, Shifa Tameer E Millat University. It is a mixed-method study. The 50 students were divided into groups A and B. Only group B was exposed to educational videos, learning materials, and conventional teaching. The assessment results of group B were compared with the results of the controlled group A. Two Focus groups were conducted with the students of Group B to gather their views.RESULTS: The results showed a significant difference in the pre-test and post-test of both groups with a P-value of 0.007. These findings suggest that the students exposed to the videos had improved grades after the intervention. In focus group interview the students believed that the blended learning approach in pre-clinical skills session has improved their knowledge, attitude, and psychomotor skills for the fabrication of acrylic partial dentures. Both methods of instruction live demonstrations and educational videos are essential as one is interactive and the other provides them an opportunity to watch the videos according to the availability of time and educational needs with a better vision of the skills being performed by the instructors.CONCLUSION: The results support that blended learning with video presentation along with traditional hands-on demonstrations in the Prosthodontic pre-clinical sessions helped students improve their knowledge, achievement of competencies, and psychomotor skills development.
Interactive Association of Posttraumatic Stress Disorder and Related Comorbidities with Loneliness on Suicidal Thoughts and Behavior in the Army National Guard
Authors: Lawrence Karen A. , Edwards Alice C. , Cerel Julie 
Published: January 2024

Abstract

The public health challenges of suicide include suicidal thoughts and behaviors (STB) such as suicidal ideation and nonfatal suicide attempts. STB precede suicide death in the ideation-to-action framework. To better understand relationships of psychiatric and psychosocial correlates of STB, this study examined associations among PTSD and related co-occurring symptoms of depression and alcohol misuse as well as their interaction with social isolation and loneliness on STB. Three hypotheses were tested in a population-based sample of 1,992 Army National Guard (ANG) members: (1) PTSD, depression, alcohol use symptom severity, and social isolation and loneliness will be associated with STB, (2) PTSD symptom severity score combined with that of depression, alcohol use, and both, will be associated with STB and explain more variation in STB than PTSD symptom severity alone, and (3) the relationship between STB and PTSD symptom severity alone and in combination with co-occurring depression and alcohol use symptom severity will be moderated by social isolation and loneliness. Notably, National Guard members face both similar and distinct stressors compared to active-duty military. Our findings suggest associations between mental health symptom severity and STB in the ANG are similar to those of the larger veteran population. Findings from the interaction analysis suggest that addressing social isolation and loneliness in the context of PTSD may decrease STB and may be especially important when PTSD symptoms are accompanied by co-occurring depressive symptoms or alcohol misuse.
Role of KMT2B and KMT2D histone 3, lysine 4 methyltransferases and DNA oxidation status in circulating breast cancer cells provide insights into cell-autonomous regulation of cancer stem cells
Authors: Ferrer-Diaz Alejandra I. , Sinha Garima , Petryna Andrew , Gonzalez-Bermejo Ruth , Kenfack Yannick , Adetayo Oluwadamilola , Patel Shyam A. , Nehra Anupama-Hood , Rameshwar Pranela 
Published: January 2024

Abstract
Background
Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue microenvironment such as bone marrow mesenchymal stem cells (MSCs) releasing exosomes to dedifferentiate BCCs into CSCs. The exosomes cargo includes histone 3, lysine 4 (H3K4) methyltransferases, KMT2B and KMT2D. A less studied mechanism of CSC maintenance is the process of cell-autonomous regulation, leading us to examine the roles for KMT2B and KMT2D in sustaining CSCs, and their potential as drug targets.
Methods
Use of pharmacological inhibitor of H3K4 (WDR5-0103), knockdown (KD) of KMT2B or KMT2D in BCCs, real time PCR, western blot, response to chemotherapy. RNA-seq and flow cytometry of blood from BC patient for markers of CSCs and DNA hydroxylases. In vivo studies with a dormancy model for response to chemotherapy.
Results
H3K4 methyltransferases can sustain CSCs, impart chemoresistance, maintain cycling quiescence, and reduce migration and proliferation of BCCs. In vivo studies validated KMT2’s role in dormancy and identified these genes as potential drug targets. DNA methylase (DNMT), predicted within a network with KMT2 to regulate CSCs, was determined to sustain circulating CSC-like in the blood of patients.
Conclusion
CSCs are sustained by H3K4 methyltransferases and DNA methylation. Overall, the findings provide crucial insights into the epigenetic regulatory mechanisms underlying BC dormancy with KMT2B and KMT2D as potential therapeutic targets. We do not propose to change the standard of care, but to monitor circulating BCCs as a functional indicator for targeted treatment to prolong BC remission, which will partly address health disparity.
User Activities Based Trust Management Framework for Online Social Networks
Authors: Sirisala NageswaraRao , Sirisala Srinivasulu 
Published: January 2024

Abstract
The ubiquity of mobile phones and web technology has facilitated continuous communication within Online Social Networks (OSNs) such as Twitter, Instagram, Facebook, and LinkedIn. In OSNs, individuals have the capability to share posts and photos with their relatives and friends, as well as to promote and publicize their businesses. However, this also opens up the potential for malicious users to misuse personal information. Consequently, researchers have turned their attention toward proposing trust-related methods aimed at ensuring a secure environment within social networks. Trust management involves the observation and rating of each user based on his activities, ensuring that only trustworthy users are granted permission to share their activities. In this paper “User Activities Based Trust Management Framework for Online Social Networks-TMFOSN” is proposed. Where users trust values are managed and keep getting updated through the different phases like trust computation, aggregation, propagation, and updations. In TMFOSN, user direct and indirect trust is evaluated with reference of Twitter social network dataset. The performance of TMFOSN is compared with other trust estimation methods, where it is outperformed with increased number of user profiles.
Prelacteal Feeding Practice among Primipara Mothers in Urban Northwest Ethiopia: A Cross-Sectional Study
Authors: Ayalew Tilksew 
Published: January 2024

Abstract
Background: Breast feeding can save millions of lives and billions of dollars each year. It is a promising intervention to achieve Sustainable Development Goals. It makes the world healthier, smarter and more equal. However, sub-optimal infant feeding like prelacteal feeding can hamper these invaluable contributions of breast feeding. Understanding the level and influencing factors of prelacteal feeding among primipara mothers could have important implications to improve infant feeding and shade lights on breast feeding study among this group of population. Therefore, this study aimed to investigate prelacteal feeding practice and its predictors among primipara mothers.
Method: A community- based cross-sectional study was conducted from March 01 to April 30 2016 among (n=398) randomly selected primipara mothers in Bahir Dar city, North West Ethiopia. Data were collected using a structured interviewer-administered questionnaire and analyzed using SPSS version25. Bivariable and multivariable logistic regression analyses were executed to identify influencing factors of prelacteal feeding. Statistical significance for dependent and independent variables association was declared at P-value ≤0.05, and the strength of associations were measured using odds ratio with 95% confidence interval.
Result: The current study revealed that prelacteal feeding was practiced by 15.8 % of primipara mothers. Primipara mothers, who were delivered via normal delivery (aOR=10.6, 95%CI; 1.40-80.9) and who initiated breastfeeding early (aOR=3.73, 9% CI; 1.63-8.58) were less likely to practice prelacteal feeding.
Conclusion: This study revealed that prelacteal feeding is a common practice in the study area. Mode of delivery and timely initiation of breastfeeding were exclusive predictors of prelacteal feeding practice. Consequently, it was recommended that health care providers who work in maternity unity and other stakeholders should discourage unnecessary cesarean deliveries and promote timely initiation of breast feeding to hinder prelacteal feeding practice.
RELM-β knockout inhibits the development of hypoxia-induced pulmonary hypertension through PLC-IP3R-Ca2+ signaling pathway
Authors: Liu Guoyu , Tian Heshen , Liu Yi , Xing Yan , Wu Ying , Liu Lei , Fu Daiyan , Chen Huilian , Zhang Chao , Dai Aiguo 
Published: January 2024

Abstract
Purpose Pulmonary vascular remodeling (PVR) is an important pathological mechanism of hypoxia-induced pulmonary hypertension (HPH), in which the proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role. Resistin-like molecule beta (RELM-β), a secretory protein, can promote the proliferation of PASMCs induced by hypoxia. As an important signaling molecule, Ca2+ plays an important role in cell proliferation. RELM-β can regulate cell proliferation by changing the intracellular calcium concentration ([Ca2+]i), but the specific regulatory mechanism of RELM-β on Ca2+ and the pathogenesis of HPH has not been fully elucidated.
Methods We employed both in vivo and in vitro RELM-β knockout (RELM-β-/-) models to examine the effects of RELM-β on pulmonary hemodynamics, PASMCs proliferation, intracellular Ca2+ release, and associated mechanisms.
Results The expression of RELM-β increased in rat HPH model and hypoxia treated PASMCs, which led to pulmonary hemodynamic changes (increased mean pulmonary artery pressure (mPAP), right ventricular hypertrophy, pulmonary artery thickening) and PASMCs proliferation. However, knockout of RELM-β had the opposite effect. RELM-β deletion decreased the expression of phospholipase C (PLC), inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), and [Ca2+]i. In addition, inhibition of PLC and IP3R can reduce [Ca2+]i.
Conclusion Our research results have confirmed the role of RELM-β as a cytokine-like growth factor in the proliferation of PASMCs and contribute to HPH. This was achieved by upregulating [Ca2+]i through the PLC/IP3R pathway.