bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Microporous Poly(Arylene Ether) Platform for Membrane‐Based Gas Separation**
Authors: Guo Sheng , Yeo Jing Ying , Benedetti Francesco M. , Syar Duha , Swager Timothy M. , Smith Zachary P. 
Published: December 2023

AbstractMembrane‐based gas separations are crucial for an energy‐efficient future. However, it is difficult to develop membrane materials that are high‐performing, scalable, and processable. Microporous organic polymers (MOPs) combine benefits for gas sieving and solution processability. Herein, we report membrane performance for a new family of microporous poly(arylene ether)s (PAEs) synthesized via Pd‐catalyzed C−O coupling reactions. The scaffold of these microporous polymers consists of rigid three‐dimensional triptycene and stereocontorted spirobifluorene, endowing these polymers with micropore dimensions attractive for gas separations. This robust PAE synthesis method allows for the facile incorporation of functionalities and branched linkers for control of permeation and mechanical properties. A solution‐processable branched polymer was formed into a submicron film and characterized for permeance and selectivity, revealing lab data that rivals property sets of commercially available membranes already optimized for much thinner configurations. Moreover, the branching motif endows these materials with outstanding plasticization resistance, and their microporous structure and stability enables benefits from competitive sorption, increasing CO2/CH4 and (H2S+CO2)/CH4 selectivity in mixture tests as predicted by the dual‐mode sorption model. The structural tunability, stability, and ease‐of‐processing suggest that this new platform of microporous polymers provides generalizable design strategies to form MOPs at scale for demanding gas separations in industry.
Synergy of Oxygen Vacancies and Base Sites for Transfer Hydrogenation of Nitroarenes on Ceria Nanorods
Authors: Yuan Ziliang , Huang Liang , Liu Yuanshuai , Sun Yong , Wang Guanghui , Li Xun , Lercher Johannes A. , Zhang Zehui 
Published: December 2023

AbstractCeO2 nanorod based catalysts for the base‐free synthesis of azoxy‐aromatics via transfer hydrogenation of nitroarenes with ethanol as hydrogen donor have been synthesized and investigated. The oxygen vacancies (Ov) and base sites are critical for their excellent catalytic properties. The Ov, i.e., undercoordinated Ce cations, serve as the sites to activate ethanol and nitroarenes by lowering the energy barrier to transfer hydrogen from α−Csp3−H in ethanol to the nitro group coupling it to the redox reactions between Ce3+ and Ce4+. At the same time, the base sites catalyze the condensation step to selectively produce azoxy‐aromatics. The catalytic route opens a much improved way to use non‐noble metal oxides without additives for the selective functional group reduction and coupling reactions.
Synthesis of α,ω‐End Functionalized Polydienes: Allylic‐Bearing Heteroleptic Aluminums for Selective Alkylation and Transalkylation in Coordinative Chain Transfer Polymerization
Authors: Liu Pibo , Yang Xiao , Li He , Zhang Songbo , Hu Yanming , Zhou Guangyuan , Hadjichristidis Nikos 
Published: December 2023

AbstractThere are still challenges in the preparation of difunctional stereoregular polydienes, especially for the construction of initiating chain‐end functionalization. Coordinative chain transfer polymerization (CCTP) provides a way to achieve the goal but usually requires sophisticated functionalized catalysts as well as expensive chain transfer agents (CTAs). In this work, heteroleptic aluminum with oligo(dienyl) substituents (oligo‐Al agents) were readily prepared by living anionic polymerization (LAP) technique. The oligo‐Al agents used in Nd‐mediated CCTPs of dienes exhibit highly selective alkylation and transalkylation features. Kinetics and transfer efficiency studies using 1H NMR, 13C NMR, 1H‐13C HSQC, and Dosy NMR analyses revealed that the resulting polydienes possess substituents at the initiating chain‐end that have transferred from the oligo‐Al agents. The functionalization efficiency of the initiating chain‐end is up to 99 %, and the molar mass regulation efficiency of heteroleptic aluminum is higher than that of the traditional CTA AliBu2H (0.608 vs. 0.410). Based on the experimental results and density functional theory (DFT) calculations, we propose a mechanism in which allylic‐Al acts as an efficient alkylating moiety in catalyst preformation and also as an effective transfer agent in polymerization. Taking advantage of these features, di‐functionalized polyisoprene, polybutadiene, and poly(isoprene‐co‐butadiene) can be facilely synthesized.
Adjusting the Architecture of Heptagonal Metallo‐Macrocycles by Embedding Metal Nodes into the Backbone
Authors: Zhao He , Wijerathna A. M. Shashika D. , Dong Qiangqiang , Bai Qixia , Jiang Zhiyuan , Yuan Jie , Wang Jun , Chen Mingzhao , Zirnheld Markus , Li Rockwell , Liu Die , Wang Pingshan , Zhang Yuan , Li Yiming 
Published: December 2023

AbstractCoordination‐driven self‐assembly has been extensively employed for the bottom‐up construction of discrete metallo‐macrocycles. However, the prevalent use of benzene rings as the backbone limits the formation of large metallo‐macrocycles with more than six edges. Herein, by embedding metal nodes into the ligand backbone, we successfully regulated the ligand arm angle and assembled two giant heptagonal metallo‐macrocycles with precise control. The angle between two arms at position 4 of the central terpyridine (tpy) extended after complexation with metal ions, leading to ring expansion of the metallo‐macrocycle. The assembled structures were straightforwardly identified through multi‐dimensional NMR spectroscopy (1H, COSY, NOESY), multidimensional mass spectrometry analysis (ESI‐MS and TWIM‐MS), transmission electron microscopy (TEM), as well as scanning tunneling microscopy (STM). In addition, the catalytic performances of metallo‐macrocycles in the oxidation of thioanisole were studied, with both supramolecules exhibiting good conversion rates. Furthermore, fiber‐like nanostructures were observed from single‐molecule heptagons by hierarchical self‐assembly.
Living Materials Based Dynamic Information Encryption via Light‐Inducible Bacterial Biosynthesis of Quantum Dots
Authors: Niu Luqi , Yu Lin , Jin Chenyang , Jin Kai , Liu Zhen , Zhu Tao , Zhu Xiaohui , Zhang Yong , Wu Yihan 
Published: December 2023

AbstractMicrobial biosynthesis, as an alternative method for producing quantum dots (QDs), has gained attention because it can be conducted under mild and environmentally friendly conditions, distinguishing it from conventional chemical and physical synthesis approaches. However, there is currently no method to selectively control this biosynthesis process in a subset of microbes within a population using external stimuli. In this study, we have attained precise and selective control over the microbial biosynthesis of QDs through the utilization of an optogenetically engineered Escherichia coli (E. coli). The recombinant E. coli is designed to express smCSE enzyme, under the regulation of eLightOn system, which can be activated by blue light. The smCSE enzymes use L‐cysteine and Cd2+ as substrates to form CdS QDs. This system enables light‐inducible bacterial biosynthesis of QDs in precise patterns within a hydrogel for information encryption. As the biosynthesis progresses, the optical characteristics of the QDs change, allowing living materials containing the recombinant E. coli to display time‐dependent patterns that self‐destruct after reading. Compared to static encryption using fluorescent QD inks, dynamic information encryption based on living materials offers enhanced security.
Enrichment of EPA and DHA by enzymatic ethanolysis: Effects of lipases from Thermomyces lanuginosus, Rhizomucor miehei, Rhizopus oryzae and Candida antarctica
Authors: Qiao Miao , Hua Xin , Yuan Yongjun , Cao Xi 
Published: December 2023

AbstractThis work attempts to achieve the enrichment of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in acylglycerols as well as biodiesel production by investigating the performance of various lipases in ethanolysis. The ethanolysis activities of five immobilized lipases in decreasing order were as follows: Lipozyme TL IM, Novozym 40086/Lipozyme RM IM, Novozym 435 and Rhizopus oryzae lipase immobilized on polypropylene (RO PP). EPA could be enriched to a certain content by Lipozyme TL IM, Novozym 40086, Lipozyme RM IM, and RO PP. The enrichment of DHA was achieved well by those four sn‐1,3 regioselective lipases, and DHA contents in acylglycerols were the highest when Lipozyme TL IM and Novozym 40086 were used, reaching 2.87‐fold and 2.81‐fold of the initial content. However, Novozym 435 could not enrich EPA and DHA effectively. Fatty acid ethyl esters produced in this work contained abundant palmitic acid and palmitoleic acid, which could be ideal biodiesel considering their chain length. The competitive factors of five lipases towards DHA were all significantly higher than those towards EPA. When Lipozyme TL IM and Novozym 40086 achieved the maximum DHA contents, their DHA recoveries in acylglycerols reached 91.87% and 89.00%, respectively. The DHA recoveries were all significantly higher than the corresponding EPA recoveries in the reactions catalyzed by five lipases. Moreover, Lipozyme TL IM could be a potential lipase for the separation of EPA and DHA. This study may promote the full use of fish oil and broaden the application of lipases.
Boosting the Performance of Zn Electrode in Aqueous Electrolytes via Trace Amount of Organic Molecules
Authors: Huang Haiji , Wang Yan , Xie Dongmei , Sun Jianyang , Zhao Jiachang , Rao Pinhua , Mook Choi Won , Mao Jianfeng 
Published: December 2023

AbstractThe poor performance of Zn electrode in aqueous electrolytes prevents the practical application of aqueous zinc‐ion batteries (AZIBs). Here, 2‐Pyrrolidinone (Pr) is introduced into conventional ZnSO4 electrolytes as additive and only 3 vol.% addition (Pr−to−H2O volume ratio) enables boosted performance. The Pr molecules are preferentially adsorbed on the surface of Zn electrodes to promote the uniform deposition of Zn ions and modulate the solvation structure of Zn2+ to inhibit the side reactions. As a result, the Zn electrode is boosted to run over 1200 h during charge/discharge cycling processes and delivers high average coulombic efficiency (CE) of 99.9 % under 1 mA cm−2, 1 mAh cm−2. Even under harsh testing conditions of 20 mA cm−2 and 20 mAh cm−2, Zn electrode still run over 100 h, which is much longer than that at pristine electrolyte (25 h). Moreover, the Zn||MnO2 full cells with the Pr additive exhibit a high capacity of 201 mAh g−1 and good capacity retention of 89 % after 550 cycles at 0.5 A g−1.
Quantitative analysis of the impact of membrane permeability on intestinal first‐pass metabolism of CYP3A substrates
Authors: Yasugi Yugo , Shirasaka Yoshiyuki , Tamai Ikumi 
Published: December 2023

AbstractThe aim of this study was firstly to investigate the effect of membrane permeability on the intestinal availability (Fg) of 10 cytochrome P450 3A4 substrates with differing permeability (Papp) and metabolic activity (CLint) using Madin‐Darby canine kidney II (MDCKII) cells expressing human CYP3A4 (MDCKII/CYP3A4 cells), and secondly to confirm the essential factors by simulations. A membrane permeation assay using MDCKII/CYP3A4 cells showed a significant correlation between human intestinal extraction ratio (ER) (Eg (=1 − Fg)) and in vitro cellular ER (r = 0.834). This relationship afforded better predictability of Eg values than the relationship between Eg and CLint,HIM values obtained from human intestinal microsomes (r = 0.598). An even stronger correlation was observed between 1 − Fa·Fg and ER (r = 0.874). Simulation with a cellular kinetic model indicated that ER is sensitive to changes of PSpassive and CLint values, but not to the intracellular unbound fraction (fu,cell) or P‐gp‐mediated efflux (PSP − gp). It may be concluded that, based on the concentration–time profile of drugs in epithelial cells, transmembrane permeability influences Fg (or ER) and drug exposure time to metabolizing enzymes for P450 substrate.
Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone
Authors: El Hamd Mohamed A. , El‐Maghrabey Mahmoud , Almawash Saud , Radwan Aya Saad , El‐Shaheny Rania , Magdy Galal 
Published: December 2023

AbstractVanillin is a flavouring agent that is prohibited for use in infant food products with ages lower than 6 months. Excessive vanillin usage could lead to eating disorders, nausea, headache, and vomiting. Therefore, it is essential to control the contents of vanillin in food samples, especially in infant formula. Here, we developed a highly sensitive nanosensor for vanillin based on using green synthesized highly fluorescent (QY = 29.5%) N‐doped carbon quantum dots (N‐CQDs) as a turn‐off fluorescent nanoprobe. The N‐doped CQDs synthesis was adopted using citrus bulb squeeze extract and the commonly used fertilizer, urea, as substrates. After mixing with vanillin, the fluorescence of the N‐CQDs was largely quenched in a vanillin concentration‐dependent manner. The sensing conditions were optimized by quality‐by‐design using a two‐level full factorial design (22 FFD). The N‐doped CQDs could detect vanillin in the range 0.1–12.0 μg/ml with a limit of detection of 0.013 μg/ml. Next, a smartphone imaging‐based assay combined with a UV chamber was adopted and applied for vanillin determination. This simple detection technique showed sensitivity similar to that of the conventional fluorimetric method. Both conventional and smartphone‐based methods were successfully applied for the determination of vanillin in infant milk formula and biscuits and could detect real vanillin concentrations in the analyzed samples with high % recoveries (94.5% to 105.5%). At last, the biocompatibility of the newly synthesized N‐CQDs was tested, and it was found to be an excellent candidate for cancer cell imaging.
The relationship between clinicopathological variables, systemic inflammation, and CT‐derived body composition with survival in patients with advanced non‐small cell lung cancer receiving nivolumab as a second‐line treatment
Authors: Saeed Randa , McGovern Josh , Bench Hugo , Dolan Ross D. , McMillan Donald C. , Cascales Almudena 
Published: December 2023

AbstractBackgroundSecond‐line immunotherapy is currently recognized to help only a subset of patients with advanced forms of non‐small cell lung cancer (NSCLC). The current study analyzes the connection between prior treatment host/tumor characteristics and survival in advanced NSCLC patients receiving nivolumab as a second‐line therapy.MethodsA retrospective cohort analysis was carried out on individuals with advanced NSCLC receiving second‐line Nivolumab with palliative intent between February 2016 and May 2019 across three health boards in NHS Greater Glasgow and Clyde, Lanarkshire, Ayrshire, and Arran in Scotland to examine the association between systemic inflammation, body composition, and survival were determined using computed tomography (CT).ResultsThe current study investigates the connection between prior treatment host/tumor characteristics and survival in advanced NSCLC patients receiving nivolumab as a second‐line therapy. The majority were 65 years of age or older (51%), female (53%), had adenocarcinoma (53%), and had good performance status (ECOG 0/1) (86%). Most patients had high SFI (70%) or VFA (54%). The median overall survival after starting Nivolumab was 15 months. ECOG‐PS and hypoalbuminemia were significant predictors of 12‐month survival in patients with advanced NSCLC following Nivolumab treatment, according to Cox regression (p‐value = 0.047 and 0.014, respectively).ConclusionIn patients with advanced NSCLC receiving Nivolumab as a second‐line therapy, ECOG‐PS and hypoalbuminemia were strongly associated with survival. Systemic inflammation and hypoalbuminemia measurements may enhance the ECOG‐PS stratification of expected outcomes.
Linagliptin in combination with insulin suppresses apoptotic unfolded protein response in ovaries exposed to type 1 diabetes
Authors: Okan Aslı , Demir Necdet , Doğanyiğit Züleyha 
Published: December 2023

AbstractType 1 diabetes mellitus (T1DM) is one of the main causes of ovarian atresia, but its molecular effect on the ovaries is not fully understood. Accumulating evidence suggests that T1DM causes excessive endoplasmic reticulum (ER) stress and insufficient adaptive unfolded protein response that triggers proapoptotic signaling pathways in ovarian tissue. In addition, problems such as amenorrhea and infertility, which are frequently seen in women with T1DM, continue despite the intensification of insulin therapy and improvement of metabolic control. Therefore new, and adjunctive treatments for women with T1DM need to be explored. We aimed to examine how the use of linagliptin, which has blood sugar‐lowering effects and high antioxidant activity, together with insulin affects the expression levels of proteins and genes that play a role in ER stress in type 1 diabetic mouse ovaries. Eighty‐four Balb/C 6‐week‐old female mice were randomly divided into seven groups: control, vehicle, diabetes + insulin, diabetes + linagliptin, diabetes + linagliptin + insulin, diabetes + TUDCA, and diabetes + TUDCA + insulin. TUDCA (an inhibitor of ER stress) groups are positive control groups created to compare linagliptin groups in terms of ER stress. Linagliptin and TUDCA were given by oral gavage and 1U insulin was administered subcutaneously for 2 weeks. A significant decrease was observed in the MDA and NOX1 levels and the number of atretic follicles in the ovaries of the diabetes + linagliptin + insulin group compared to the diabetes + insulin group. The use of linagliptin and insulin increased the expression of pro‐survival XBP1s transmembrane protein and decreased the expression of proapoptotic ATF4, pJNK1/2, cleaved caspase 12, and cleaved caspase 3 in mouse ovaries. Our study provides new therapeutic evidence that linagliptin administered in addition to insulin induces ER stress mechanism‐dependent survival in ovaries with type 1 diabetes.
Review of intravascular lithotripsy for treating coronary, peripheral artery, and valve calcifications
Authors: Gruslova Aleksandra B. , Inanc Ibrahim H. , Cilingiroglu Mehmet , Katta Nitesh , Milner Thomas E. , Feldman Marc D. 
Published: December 2023

AbstractManagement of intracoronary calcium (ICC) continues to be a challenge for interventional cardiologists. There have been significant advances in calcium treatment devices. However, there still exists a knowledge gap regarding which devices to choose for the treatment of ICC. The purpose of this manuscript is to review the principles of intravascular lithotripsy (IVL) and clinical data. The technique of IVL will then be compared to alternative calcium treatment devices. Clinical data will be reviewed concerning the treatment of coronary, peripheral artery and valvular calcifications. Controversies to be discussed include how to incorporate IVL into your practice, what is the best approach for treating calcium subtypes, how to approach under‐expanded stents, what is the ideal technique for performing IVL, how safe is IVL, whether imaging adds value when performing IVL, and how IVL fits into a treatment program for peripheral arteries and calcified valves.
Intra‐stent aortic wall aneurysm formation after Be‐graft covered stent implant
Authors: Bianco Lisa , Rebonato Micol , Butera Gianfranco 
Published: December 2023

AbstractAortic wall injuries may occur after interventional treatment of aortic coarctation (CoA), especially after balloon angioplasty. We reported on a patient who presented with an intra‐stent aneurysm formation after direct stenting of a native near atretic aortic CoA by using a BeGraft Aortic stent. This evidence supports the need to maintain a strict follow‐up protocol. A computed tomography scan is mandatory, after covered stent implantation as well, especially in high‐risk cases and even in the absence of any immediate apparent complication.
A case report of angiosarcoma originating from the tongue
Authors: Kusaka Iori , Katagiri Katsunori , Saito Daisuke , Ohashi Yu , Oikawa Shin‐ichi , Tsuchida Kodai , Miyaguchi Jun , Kusaka Takahiro , Ikeda Ryoukichi , Shiga Kiyoto 
Published: December 2023

Key Clinical MessageAngiosarcoma is a rare malignant disease with an extremely poor prognosis, showing rapid progression of the local tumor and/or distant metastases. Although multidisciplinary approach including systemic chemotherapy and radiation therapy is ideal for this disease, surgical resection have a role in disease control and should be performed as soon as possible.AbstractAngiosarcomas originating from the tongue are rare and have extremely malignant features, leading to a poor prognosis. Herein, we report the case of a patient with angiosarcoma arising from the tongue who was successfully treated surgically. A 71‐year‐old man was diagnosed with a mass on the right side of his tongue and visited the Department of Oral and Maxillofacial Surgery at our hospital. The patient was referred to our department for further examination and treatment after a biopsy of the right edge of the tongue. An irregularly raised tumor 50 mm in length was noted on the right lingual border. The preoperative diagnosis was a primary angiosarcoma of the tongue (clinical stage, T3N2bM0, Stage IV). As his tumor had been growing rapidly, he emergently underwent partial right‐sided tongue resection and right neck dissection without reconstructive surgery. The histopathological diagnosis was pT3N0. Postoperatively, the patient showed no signs of recurrence or metastasis during the 1‐year follow‐up. As for angiosarcomas, surgical resection is the only curative treatment, and surgery should be performed as soon as possible after the final diagnosis.
Influence of Environmental Conditions on Electrocatalytic CO2 Reduction
Authors: Hu Lang , Sai Xuxu , Liu Xiaoju , Chen Zhou , Wang Guoxiong , Yi Xiaodong 
Published: December 2023

AbstractIn order to address the greenhouse effect and achieve the artificial carbon cycle, the electrocatalytic reduction reactions offer an effective approach for converting carbon dioxide (CO2) into valuable chemicals. In addition to the rational design of catalyst structure to improve the high selective conversion of CO2, exploring the influence of environmental conditions on the reaction path and product types is one of the keys to realizing the high selective conversion of CO2. In this review, we illustrate the important influence of changes in environmental conditions on the effectiveness of electrocatalytic carbon dioxide reduction reaction (CO2RR) technology from the design of the reactor, the selection of the electrolyte, and the setting of the reaction conditions (pressure, temperature, etc.). Through in‐depth understanding and optimization of these factors, the efficiency and selectivity of the CO2RR can be further improved to promote the development of CO2 conversion technology.