bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the microstructure and wear resistance of AlCrCuFeNiTix high entropy alloys for surfacing welding
Authors: Zhang Wen , Su Yunhai , Zhang Guiqing , Liang Xuewei 
Published: February 2024

Abstract
In order to investigate the effect of Ti element content on the microstructure and wear resistance of AlCrCuFeNiTix (x = 0, 0.3, 0.6, 0.9) high entropy surfacing alloy, a melting electrode gas shielded welding technology was used to prepare AlCrCuFeNiTix high entropy surfacing alloy on the surface of carbon steel plates. The microstructure, phase composition, and wear resistance of the alloy were analyzed. The results show that the phase composition of the surfacing alloy becomes a BCC+FCC solid solution phase, with a much higher content of BCC phase than FCC phase. The microstructure consists of disordered BCC phase rich in Fe and Cr, ordered BCC phase rich in Al and Ni, and FCC phase rich in Cu. The microstructure exhibits typical dendritic (DR) and interdendritic (ID) structures. With the increase of Ti element, hard Fe2Ti phase precipitates in the interdendritic zone, and the micro hardness of the alloy shows an increasing trend. The maximum hardness can reach 636 HV, which is 2.4 times that of the base material. With the increase of Ti element, the friction coefficient of the alloy shows a trend of first decreasing and then increasing, and the wear amount first decreases and then increases. When Ti is 0.6, the wear resistance of the high entropy surfacing alloy reaches its best.
The Autonomy-Based Account of Chinese Trust Laws
Authors: Jing Hui 
Published: February 2024

Abstract
There has been considerable discussion concerning the key values or goals underpinning the express trust device in English law. However, there is as yet no existing scholarship that explores the normative values of Chinese trust law since its enactment in 2001. This Article examines Chinese trust law from the perspective of personal autonomy. It identifies three dimensions of the conception of personal autonomy and explores how the trust law rules engage with each dimension. It finds that, in China, individuals have the autonomy to use the express trust device to arrange their property plans. However, such autonomy is limited in that it can only be exercised in alignment with the state’s regulatory goals. This is in stark contrast to its English counterpart, which allows individual autonomy to the largest possible extent. This Article considers the implications this analysis has for the reformation of Chinese trust law. It discusses some reform proposals that have been intensely debated in recent literature and highlights the insights the autonomy-based analysis can offer.
Omics feature selection with the extended SIS R package: identification of a body mass index epigenetic multimarker in the Strong Heart Study
Authors: Domingo-Relloso Arce , Feng Yang , Rodriguez-Hernandez Zulema , Haack Karin , Cole Shelley A , Navas-Acien Ana , Tellez-Plaza Maria , Bermudez Jose D 
Published: February 2024

Abstract
The statistical analysis of omics data poses a great computational challenge given their ultra–high-dimensional nature and frequent between-features correlation. In this work, we extended the iterative sure independence screening (ISIS) algorithm by pairing ISIS with elastic-net (Enet) and 2 versions of adaptive elastic-net (adaptive elastic-net (AEnet) and multistep adaptive elastic-net (MSAEnet)) to efficiently improve feature selection and effect estimation in omics research. We subsequently used genome-wide human blood DNA methylation data from American Indian participants in the Strong Heart Study (n = 2235 participants; measured in 1989-1991) to compare the performance (predictive accuracy, coefficient estimation, and computational efficiency) of ISIS-paired regularization methods with that of a bayesian shrinkage and traditional linear regression to identify an epigenomic multimarker of body mass index (BMI). ISIS-AEnet outperformed the other methods in prediction. In biological pathway enrichment analysis of genes annotated to BMI-related differentially methylated positions, ISIS-AEnet captured most of the enriched pathways in common for at least 2 of all the evaluated methods. ISIS-AEnet can favor biological discovery because it identifies the most robust biological pathways while achieving an optimal balance between bias and efficient feature selection. In the extended SIS R package, we also implemented ISIS paired with Cox and logistic regression for time-to-event and binary endpoints, respectively, and a bootstrap approach for the estimation of regression coefficients.
Predicting the role of the human gut microbiome in type 1 diabetes using machine-learning methods
Authors: Liu Xiao-Wei , Li Han-Lin , Ma Cai-Yi , Shi Tian-Yu , Wang Tian-Yu , Yan Dan , Tang Hua , Lin Hao , Deng Ke-Jun 
Published: February 2024

Abstract
Gut microbes is a crucial factor in the pathogenesis of type 1 diabetes (T1D). However, it is still unclear which gut microbiota are the key factors affecting T1D and their influence on the development and progression of the disease. To fill these knowledge gaps, we constructed a model to find biomarker from gut microbiota in patients with T1D. We first identified microbial markers using Linear discriminant analysis Effect Size (LEfSe) and random forest (RF) methods. Furthermore, by constructing co-occurrence networks for gut microbes in T1D, we aimed to reveal all gut microbial interactions as well as major beneficial and pathogenic bacteria in healthy populations and type 1 diabetic patients. Finally, PICRUST2 was used to predict Kyoto Encyclopedia of Genes and Genomes (KEGG) functional pathways and KO gene levels of microbial markers to investigate the biological role. Our study revealed that 21 identified microbial genera are important biomarker for T1D. Their AUC values are 0.962 and 0.745 on discovery set and validation set. Functional analysis showed that 10 microbial genera were significantly positively associated with D-arginine and D-ornithine metabolism, spliceosome in transcription, steroid hormone biosynthesis and glycosaminoglycan degradation. These genera were significantly negatively correlated with steroid biosynthesis, cyanoamino acid metabolism and drug metabolism. The other 11 genera displayed an inverse correlation. In summary, our research identified a comprehensive set of T1D gut biomarkers with universal applicability and have revealed the biological consequences of alterations in gut microbiota and their interplay. These findings offer significant prospects for individualized management and treatment of T1D.
Promises of parallel outcomes
Authors: Zhou Ying , Tang Dingke , Kong Dehan , Wang Linbo 
Published: February 2024

Summary
A key challenge in causal inference from observational studies is the identification and estimation of causal effects in the presence of unmeasured confounding. In this paper, we introduce a novel approach for causal inference that leverages information in multiple outcomes to deal with unmeasured confounding. An important assumption in our approach is conditional independence among multiple outcomes. In contrast to existing proposals in the literature, the roles of multiple outcomes in the conditional independence assumption are symmetric; hence, the name parallel outcomes. We show nonparametric identifiability with at least three parallel outcomes and provide parametric estimation tools under a set of linear structural equation models. Our proposal is evaluated through a set of synthetic and real data analyses.
Prediction, screening and characterization of novel bioactive tetrapeptide matrikines for skin rejuvenation
Authors: Jariwala Nathan , Ozols Matiss , Eckersley Alexander , Mambwe Bezaleel , Watson Rachel E B , Zeef Leo , Gilmore Andrew , Debelle Laurent , Bell Mike , Bradley Eleanor J , Doush Yegor , Keenan Amy , Courage Carole , Leroux Richard , Peschard Olivier , Mondon Philippe , Ringenbach Caroline , Bernard Laure , Pitois Aurelien , Sherratt Michael J 
Published: February 2024

Abstract

Background
Extracellular matrices play a critical role in tissue structure and function and aberrant remodelling of these matrices is a hallmark of many age-related diseases. In skin, loss of dermal collagens and disorganization of elastic fibre components are key features of photoageing. Although the application of some small matrix-derived peptides to aged skin has been shown to beneficially affect in vitro cell behaviour and, in vivo, molecular architecture and clinical appearance, the discovery of new peptides has lacked a guiding hypothesis.

Objectives
To identify, using protease cleavage site prediction, novel putative matrikines with beneficial activities for skin composition and structure.

Methods
Here, we present an in silico (peptide cleavage prediction) to in vitro (proteomic and transcriptomic activity testing in cultured human dermal fibroblasts) to in vivo (short-term patch test and longer-term split-face clinical study) discovery pipeline, which enables the identification and characterization of peptides with differential activities.

Results
Using this pipeline we showed that cultured fibroblasts were responsive to all applied peptides, but their associated bioactivity was sequence-dependent. Based on bioactivity, toxicity and protein source, we further characterized a combination of two novel peptides, GPKG (glycine–proline–lysine–glycine) and LSVD (leucine–serine–valine–aspartate), that acted in vitro to enhance the transcription of matrix ­organization and cell proliferation genes and in vivo (in a short-term patch test) to promote processes associated with epithelial and dermal maintenance and remodelling. Prolonged use of a formulation containing these peptides in a split-face clinical study led to significantly improved measures of crow’s feet and firmness in a mixed population.

Conclusions
This approach to peptide discovery and testing can identify new synthetic matrikines, providing insights into biological mechanisms of tissue homeostasis and repair and new pathways to clinical intervention.
Minimizing Low-Value, Uncompensated Work in Academic Infectious Diseases: A 6-Step Program
Authors: Bearman Gonzalo , Nori Priya 
Published: February 2024

Abstract
Uncompensated work in academic infectious diseases (ID) may be high value (eg, important for academic promotion or necessary for advancement to leadership roles) or low value (eg, not aligning with or contributing to professional goals and aspirations). “Curbside” consultations, participation in hospital committees outside of professional interests, and other “citizenship” tasks are common examples of threats to our valuable time as ID providers. Herein, we define the scope of the problem of low-value uncompensated work in academic ID and outline a 6-step program to minimize these threats. Collaboration with professional sponsors, such as division chiefs, to align individual and team goals and use of a “value-versus-compensation” matrix to prioritize activities may help us establish our own agendas and reclaim our professional autonomy.
LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation
Authors: Murphy Matthew B , Yang Zhenjiang , Subati Tuerdi , Farber-Eger Eric , Kim Kyungsoo , Blackwell Daniel J , Fleming Matthew R , Stark Joshua M , Van Amburg Joseph C , Woodall Kaylen K , Van Beusecum Justin P , Agrawal Vineet , Smart Charles D , Pitzer Ashley , Atkinson James B , Fogo Agnes B , Bastarache Julie A , Kirabo Annet , Wells Quinn S , Madhur Meena S , Barnett Joey V , Murray Katherine T 
Published: February 2024

Abstract

Aims
The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and haematologic disorders, including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk−/− mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are the major components of oxidative injury, and we further hypothesized that these mediators are critical drivers of the AF substrate in Lnk−/− mice.

Methods and results
Lnk−/− or wild-type (WT) mice were treated with vehicle or 2-hydroxybenzylamine (2-HOBA), a dicarbonyl scavenger, for 3 months. Compared with WT, Lnk−/− mice displayed increased AF duration that was prevented by 2-HOBA. In the Lnk−/− atria, action potentials were prolonged with reduced transient outward K+ current, increased late Na+ current, and reduced peak Na+ current, pro-arrhythmic effects that were inhibited by 2-HOBA. Mitochondrial dysfunction, especially for Complex I, was evident in Lnk−/− atria, while scavenging lipid dicarbonyls prevented this abnormality. Tumour necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) were elevated in Lnk−/− plasma and atrial tissue, respectively, both of which caused electrical and bioenergetic remodelling in vitro. Inhibition of soluble TNF-α prevented electrical remodelling and AF susceptibility, while IL-1β inhibition improved mitochondrial respiration but had no effect on AF susceptibility. In a large database of genotyped patients, rs3184504 was associated with AF, as well as AF-related stroke.

Conclusion
These findings identify a novel role for LNK in the pathophysiology of AF in both experimental mice and humans. Moreover, reactive lipid dicarbonyls are critical to the inflammatory AF substrate in Lnk−/− mice and mediate the pro-arrhythmic effects of pro-inflammatory cytokines, primarily through electrical remodelling.
Artificial intelligence-based automated preprocessing and classification of impacted maxillary canines in panoramic radiographs
Authors: Abdulkreem Ali , Bhattacharjee Tanmoy , Alzaabi Hessa , Alali Kawther , Gonzalez Angela , Chaudhry Jahanzeb , Prasad Sabarinath 
Published: February 2024

Abstract

Objectives
Automating the digital workflow for diagnosing impacted canines using panoramic radiographs (PRs) is challenging. This study explored feature extraction, automated cropping, and classification of impacted and nonimpacted canines as a first step.

Methods
A convolutional neural network with SqueezeNet architecture was first trained to classify two groups of PRs (91with and 91without impacted canines) on the MATLAB programming platform. Based on results, the need to crop the PRs was realized. Next, artificial intelligence (AI) detectors were trained to identify specific landmarks (maxillary central incisors, lateral incisors, canines, bicuspids, nasal area, and the mandibular ramus) on the PRs. Landmarks were then explored to guide cropping of the PRs. Finally, improvements in classification of automatically cropped PRs were studied.

Results
Without cropping, the area under the curve (AUC) of the receiver operating characteristic (ROC) curve for classifying impacted and nonimpacted canine was 84%. Landmark training showed that detectors could correctly identify upper central incisors and the ramus in ∼98% of PRs. The combined use of the mandibular ramus and maxillary central incisors as guides for cropping yielded the best results (∼10% incorrect cropping). When automatically cropped PRs were used, the AUC-ROC improved to 96%.

Conclusions
AI algorithms can be automated to preprocess PRs and improve the identification of impacted canines.
English Patriotism and the Implicit Nation: Homelands and Soldiers’ National Identity during the Great War
Authors: Mayhew Alex 
Published: February 2024

Abstract
This article explores the patriotism and national identity of English soldiers during the First World War. Using this conflict as a case-study, it draws together work on Great War mentalities and scholarship on Englishness. It argues that individuals’ national identity focused on and formed around the ‘implicit nation’, which was primarily concerned with communities and parochial local (or regional) spaces. There was no ‘essential’ England: the homeland could be rural or urban, natural or human. English national identity embraced this plurality. Using published material, soldiers’ newspapers and private letters, diaries and postcards, this article highlights the ways in which allegiance to an ‘implicit nation’ was nurtured by a military that championed local and regional identities. As subjects, not citizens, soldiers naturally centred their attention on the communities and landscapes of their homeland. The war did not diminish men’s emotional connections to these homelands; in fact, it made them all the stronger. In concentrating on the subjective and emotional features of patriotism, this paper suggests that Englishness was inherently heterogeneous and drew its strength from this. Rather than a commitment to abstract structures such as the state, or theoretical political principles, it argues that English national identity embraced a composite, or patchwork, of mutually supporting patriotisms attached to particular homelands. It was a sense of these homelands that underlay men’s identification with Britishness, the Empire and the monarchy. Importantly, soldiers’ experience of the First World War gave this a new (or at least more vocal) articulation.
Income inequality and charitable giving to different causes in China: a distribution perspective
Authors: Yang Yongzheng , Wiepking Pamala , Badertscher Katherine 
Published: February 2024

Abstract
In contexts with high-income inequality, are people more or less inclined to support those in need through philanthropy? Using data from the 2016 wave of the China Labor-Force Dynamics Study, this study examines (i) how income inequality is associated with charitable giving to high-redistributive (e.g., poverty alleviation) and low-redistributive (e.g., arts and culture) causes and (ii) the household and contextual level variation for this relationship. We conduct this study in the unique context of China, where the Communist Party and Chinese government actively encourage charitable giving to play a role in diminishing income inequality. Empirical results show that in China, income inequality has no significant relationship with charitable giving to high-redistributive causes. We do find some support for a small moderating effect of education. Those with a higher level of education living in provinces with higher income inequality give more to high-distributive causes. We also find support for a small negative association with charitable giving to low-redistributive causes, which indicates that people in a context with higher income inequality are less inclined, although not substantially, to give to low-redistributive causes.
PomBase: a Global Core Biodata Resource—growth, collaboration, and sustainability
Authors: Rutherford Kim M , Lera-Ramírez Manuel , Wood Valerie 
Published: February 2024

Abstract
PomBase (https://www.pombase.org), the model organism database (MOD) for fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the Global Biodata Coalition (GBC; https://globalbiodata.org/) after a rigorous selection process. In this MOD review, we present PomBase’s continuing growth and improvement over the last 2 years. We describe these improvements in the context of the qualitative GCBR indicators related to scientific quality, comprehensivity, accelerating science, user stories, and collaborations with other biodata resources. This review also showcases the depth of existing connections both within the biocuration ecosystem and between PomBase and its user community.
Proactive Care-Seeking Strategies Among Adults Aging Solo With Early Dementia: A Qualitative Study
Authors: Lowers Jane , Datcher Ivree , Kavalieratos Dio , Hepburn Ken , Perkins Molly M 
Published: February 2024

Abstract

Objectives
People living with dementia need increasing care over time, but 1 in 3 adults with cognitive impairment lives alone. The goal of this study was to explore the self-identified strengths and resources for future care needs of adults aging solo with early dementia.

Methods
Semistructured interviews with 15 adults not living with a partner and with no children in the same state, who self-identified as having early dementia or mild cognitive impairment; hybrid inductive/deductive reflexive thematic analysis using a successful aging framework.

Results
Participants placed a high value on maintaining independence and expressed concerns about preserving selfhood and becoming a burden to others. These values influenced how participants appraised financial and social resources available to address future care needs and strategies to preempt or respond to needs such as transportation, help with finances, or activities of daily living.

Discussion
Adults without close family are heterogeneous and have variable resources available to address care needs associated with dementia progression. Common values of retaining independence and minimizing burden to others may be helpful in motivating adults aging solo to undertake planning and help-seeking early.
Crystal structure of mango α1,3/α1,4-fucosyltransferase elucidates unique elements that regulate Lewis A-dominant oligosaccharide assembly
Authors: Okada Takahiro , Teramoto Takamasa , Ihara Hideyuki , Ikeda Yoshitaka , Kakuta Yoshimitsu 
Published: February 2024

Abstract
In various organisms, α1,3/α1,4-fucosyltransferases (CAZy GT10 family enzymes) mediate the assembly of type I (Galβ1,3GlcNAc) and/or type II (Galβ1,4GlcNAc)-based Lewis structures that are widely distributed in glycoconjugates. Unlike enzymes of other species, plant orthologues show little fucosyltransferase activity for type II-based glycans and predominantly catalyze the assembly of the Lewis A structure [Galβ1,3(Fucα1,4)GlcNAc] on the type I disaccharide unit of their substrates. However, the structural basis underlying this unique substrate selectivity remains elusive. In this study, we investigated the structure–function relationship of MiFUT13A, a mango α1,3/α1,4-fucosyltransferase. The prepared MiFUT13A displayed distinct α1,4-fucosyltransferase activity. Consistent with the enzymatic properties of this molecule, X-ray crystallography revealed that this enzyme has a typical GT-B fold-type structure containing a set of residues that are responsible for its SN2-like catalysis. Site-directed mutagenesis and molecular docking analyses proposed a rational binding mechanism for type I oligosaccharides. Within the catalytic cleft, the pocket surrounding Trp121 serves as a binding site, anchoring the non-reducing terminal β1,3-galactose that belongs to the type I disaccharide unit. Furthermore, Glu177 was postulated to function as a general base catalyst through its interaction with the 4-hydroxy group of the acceptor N-acetylglucosamine residue. Adjacent residues, specifically Thr120, Thr157 and Asp175 were speculated to assist in binding of the reducing terminal residues. Intriguingly, these structural elements were not fully conserved in mammalian orthologue which also shows predominant α1,4-fucosyltransferase activity. In conclusion, we have proposed that MiFUT13A generates the Lewis A structure on type I glycans through a distinct mechanism, divergent from that of mammalian enzymes.