bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metformin-Cimetidine Drug Interaction and Risk of Lactic Acidosis in Renal Failure: A Pharmacovigilance-Pharmacokinetic Appraisal
Authors: Xie Wenhuo , Li Jianbin , Kong Chenghua , Luo Wei , Zheng Jiaping , Zhou Yu 
Published: November 2023

OBJECTIVE
This study aimed to evaluate lactic acidosis (LA) risk when using metformin combined with histamine H2 receptor inhibitors (H2RI) in patients with renal failure (RF).

RESEARCH DESIGN AND METHODS
This study analyzed FDA Adverse Event Reporting System data (2012Q4 to 2022Q4) to characterize reports of LA associated with metformin alone or combined with H2RI. Using a disproportionality approach, LA risk signal in the overall population and in patients with RF was assessed. A physiologically based pharmacokinetic (PBPK) model was developed to predict metformin and cimetidine pharmacokinetic changes following conventional doses of the combinations in patients with various degrees of RF. To explore its correlation with LA risk, a peak plasma metformin concentration of 3 mg/L was considered the threshold.

RESULTS
Following the 2016 U.S. Food and Drug Administration metformin approval for mild-to-moderate RF, the percentage of patients with RF reporting LA associated with metformin combined with H2RI increased. Disproportionality analysis showed reported LA risk signal associated with metformin and cimetidine in the overall population within the study timeframe only. Furthermore, with PBPK simulations, for metformin (1,000 mg b.i.d.) with cimetidine (300 mg q.i.d. or 400 mg b.i.d.) in stage 1 of chronic kidney disease, metformin (1,000 mg b.i.d.) with cimetidine (300 mg q.i.d. or 400 mg b.i.d. or 800 mg q.d.) in stage 2, and most combinations in stage 3, the peak plasma metformin concentrations exceeded the 3 mg/L threshold.

CONCLUSIONS
Metformin combined with cimetidine at conventional doses may cause LA in patients with mild-to-moderate RF.
Rubber Comprehensive Constitutive Equation and the Prediction of Tire Temperature and Rolling Resistance
Authors: Assaad Mahmoud , Ebbott Tom , Jiang Bing , Rebel Gert 
Published: November 2023

ABSTRACT
Cooler running tires with a reduced rolling resistance is a consideration for both tire makers and automotive original equipment manufacturers. To investigate the mechanics of energy loss and temperature rise, a nonlinear viscoelastic model suitable for numerical analysis of rolling tires is developed and demonstrated. The rubber compounds are represented as nonlinear viscoelastic materials with temperature and frequency, strain, and strain history–dependent response. Several applications to different tire designs are provided to demonstrate the impact of this new material constitutive law in improving the quality of the numerical predictions over other methods. One application is a rolling tire model that was used to delineate the tire temperature distribution and the resultant rolling resistance for different three-dimensional tread patterns.
СУТНІСТЬ ІННОВАЦІЙНОЇ ПОЛІТИКИ В УМОВАХ ЄВРОІНТЕГРАЦІЇ
Authors: Щукін І.С. 
Published: November 2023

У статті досліджено сутність інноваційної політики, проаналізовано визначення різними авторами тапоказано особливості інноваційної політики в умовах євроінтеграції. Інноваційна політика євизначальною для конкурентоспроможності країни в цілому та окремих галузей та сегментів. Томуактуальність дослідження інноваційної політик залишається на високому рівні та є предметомвивчення багатьох вітчизняних та зарубіжних авторів. Основою підвищення ефективності веденняпідприємницької діяльності є новаторські ідеї в умовах євроінтеграції.
Ключові слова : інноваційна політика, євроінтеграція, конкурентоспроможність, новаторство.
Bioficción, memoria pública literaria y mala conciencia: Teresa de Jesús y Cristina Morales
Authors: Cabo Aseguinolaza Fernando 
Published: November 2023

Este artículo se centra en la llamada bioficción autorial para analizar su dimensión mnemónica, en el contexto contemporáneo de la idea de posteridad y su implicación en la lógica postautónoma del campo literario actual. Se parte para ello de la consideración de la aproximación de Cristina Morales a Teresa de Jesús a través de las tres ediciones de la novela titulada en un principio Malas palabras (2015) y luego Introducción a Teresa de Jesús (2020) y Últimas tardes con Teresa de Jesús (2020). En último término, se plantea las características de una figura autorial que se construye a sí misma desde un ejercicio creativo de mala conciencia, en el que la relación compleja con una autora canónica resulta determinante.
Subchondral bone sequestrum formation in the proximal intra-articular and osteochondral region of the third metatarsal bone of an Appaloosa mare treated for septic arthritis
Authors: Barton Charlotte K. , Samol Monika A. , Nelson Brad B. , Piquini Gabriella , Smanik Lauren E. , Goodrich Laurie R. 
Published: November 2023

Abstract

OBJECTIVE
To raise awareness of the potential for intra-articular subchondral bone sequestrum formation secondary to a traumatic or septic process to enable more rapid identification of this uncommon but possible outcome in future cases.

ANIMAL
A client-owned 12-year-old Appaloosa mare.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
The mare had a wound to the lateral aspect of the fourth metatarsal bone (MT4) that communicated with the distal tarsal joints. Radiographs revealed a displaced, comminuted fracture of MT4.

TREATMENT AND OUTCOME
The horse underwent aggressive debridement of the wound and MT4 as well as, on 2 occasions, needle joint lavage. Systemic, regional, and IA antibiotic therapy was also performed together with a bone graft from the tuber coxae. The horse’s comfort improved, and the wound appeared to be healing. Five weeks following discharge, the horse re-presented with a non–weight-bearing lameness and radiographs revealed marked osteomyelitis of the tarsometatarsal and distal intertarsal joints. Postmortem examination of the limb identified a sequestrum within the proximal articular surface of the third metatarsal bone.

CLINICAL RELEVANCE
The present report highlights the importance of arthroscopic lavage to visualize the cartilage surface and the benefits of advanced imaging to detect associated changes within the bone earlier than conventional radiographs. To our knowledge, no reports exist of intra-articular subchondral bone sequestra in the tarsometatarsal joint in horses.
Risk on the Tax System of the E.U. from 2016 to 2022
Authors: Challoumis Constantinos 
Published: November 2023

Abstract
This paper discusses the risks that businesses face in the tax system from the point of view of the cycle of money. The current research is about the influence of companies that participate in global tax transactions on the tax revenue. The results show that controlled transactions have a negative impact on the GDP and tax revenue, discouraging any uncontrolled investments. The diminished risk increases the tax revenue. The objective of this research is to show that a tax policy of a low tax rate increases uncontrolled transactions, leading to a growth of GDP and tax revenue. This work complies with the theory of the Cycle of Money. The impact of risk on tax revenue has been determined by comparing results with and without this factor. The Q.E. method uses mathematics and programming, allowing the determination of an appropriate equation by a feedback procedure. An econometric analysis is applied to check the results of the model. A special technique is introduced, for the first time, to identify the risk by the sensitivity impact of one factor to another one. Sensitivity is determined as the ability of one factor to counteract instantly the changes of another one. If the counteract is instant, it is considered that the sensitivity is high. If the counteract delays, it is determined that the sensitivity is low. For high sensitivity, the risk is low, and the adjustment is the appropriate one. For low sensitivity, the risk is high, as the adjustment is not adequate.
Studies on Saturation Diving in Poland and Practical Application of Their Findings. Part 2 b. Developing a Polish System of Saturation Diving in the 1980s and 1990s
Authors: Skrzyński Stanisław , Grzeczka Grzegorz 
Published: November 2023

Abstract
This article is another in a series of articles on the research and the deployment of saturation diving technology in our country. This part discusses Polish specificities and achievements against the background of economic and historical context. It describes the creation of the base for saturation diving in the times of economic hardship in our country. Over this period, the shipbuilding industry was driving saturation diving research as a basis for the construction of diving systems to be exported to secure the extraction of the resources from the sea shelf. This paper describes the efforts of the animators and protagonists of underwater research in our country, whose work is continued to this day. In its second part the author shows how the Polish system of saturation diving was created. The article also considers the technical and organisational conditions in which the first saturation dives took place and the history of the development of the Polish decompression method for saturation diving. A key role in this difficult task was played by the creation of a base for this industry and research potential, assisted by the relevant state agencies, dedicated for the defence sector. A multiannual National Research and Development Plan (Polish abbr. CPBR) was set up with objectives 9.2 and 9.5 focused on medical and technical research resulting in the development of a diving system with its organisational framework, medical safety solutions, and reliable technology. The outcomes of this programme are still being implemented today. Despite advances in the medical and technical fields as well as organisation, the problems of saturation diving are still pertinent because, regardless of its complexity and high cost, this is the most efficient diving format that allows for very deep diving operations, currently up to 400-500m.
Rescue device concept for the ARGO profiling float
Authors: Adam Olejnik A. , Walczowski Waldemar , Dawidziuk Marek , Jakus Bartłomiej , Wieczorek Piotr 
Published: November 2023

Abstract
The material presents the development work carried out by the ARGO-Poland scientific consortium related to the design of rescue systems for ARGO profiling floats used for in situ exploration of the world oceans. The article describes the principle of operation of the Argo float and the theoretical basis of the rescue system and six alternative design solutions for such a system.
Medicinal and cosmetic products used in treatment of hair loss
Authors: Abramek Natalia , Naja-Wiśniewska Magdalena , Nieradko-Iwanicka Barbara 
Published: November 2023

Abstract
Hair loss or alopecia is a reduction in the volume or complete loss of hair and is a fairly common clinical problem, especially in the geriatric population. Androgenetic alopecia (AGA) is the most common type of hair loss in men. Androgenetic alopecia in women most often occurs before the age of 60. We also distinguish androgenetic alopecia in postmenopausal women and scarring, areata, telogen and drug-induced alopecia. The aim of the study was to analyze the composition of medicinal and cosmetic preparations available on the Polish market, recommended for people struggling with alopecia. In 2022, the composition of preparations used in alopecia available in pharmacies and drugstores was analyzed.
In total 57 medicinal and cosmetic preparations recommended for people suffering from alopecia have been identified. The most common active substance in the analyzed preparations is finasteride. Frequently used active substances are biotin and minoxidil, rarely prednisolone.
Conclusions: 1. In preparations intended for people with alopecia, the most frequently used active substance is finasteride.
2. Statistically, preparations for hair loss are most often in the form of tablets and shampoos.
3. The analyzed preparations for alopecia belong to the category of prescription drugs and cosmetics, less often in the category of OTC drugs or dietary supplements.
Arguments and Counterarguments for and against Coffee in 17th-Century English Literature
Authors: Shovon Ashfaque Ahmad 
Published: November 2023

Abstract
Coffee was a foreign product in Britain, only introduced during the Post-Medieval period. The introduction was not smooth as it was viewed as a drink from the Moors or the Turks. Two groups emerged – one favouring coffee and one deriding it – and the conflicts were depicted in books, pamphlets, and leaflets of that era. Coffee faced opposition from other beverage sellers as it became a threat to their existing businesses. During its initial days, there was even a call for a baptism of the drink to wash out its “Satanic influence”. Coffee, seen as a medicine in its earlier days in Britain, became an essential part of everyday life in the late 17th century. Coffee houses became a place for public gatherings where social, political, and business discussions took place. This paper will explore the discussions and debates revolving around coffee in 17th-Century English Literature.
New stories from the Mabinogion and Pedeir Keinc y Mabinogi: Texts, Narratives and Tradition1
Authors: Janoušek Hynek Daniel 
Published: November 2023

Abstract
This paper aims to explore the migration of narrative elements from four medieval Welsh tales known as the Four Branches of the Mabinogi into four recent Englishlanguage novels which are part of Welsh publisher Seren’s series New Stories from the Mabinogion. Russel Celyn Jones’s The Ninth Wave, Owen Sheers’s White Ravens, Lloyd Jones’s See How They Run, and Gwyneth Lewis’s The Meat Tree bear an explicit textual relationship to the Four Branches of the Mabinogi, a textual whole of unknown authorship. This affords an opportunity to examine the workings of what constitutes a textual tradition, both diachronically and synchronically. The article relies on Dutch cultural theorist Mieke Bal’s structuralist theory of narrative, on Welsh philologist Sioned Davies’s analyses of the medieval tales, and on Slovak literary scholar Anton Popovič’s view of tradition in terms of prototexts and metatexts. The methodology chosen consists of identifying textual variables and invariables in order to capture possible ways of examining relationships between related texts of different periods and languages within a corpus of linguistically encoded messages of a geographically defined community.
In Vitro Callogenesis of Murici-Pitanga (Byrsonima gardneriana a. Juss.) Malpighiaceae
Authors: Santos Michele Lima de Souza , Roque Jozilene Lima , Das Neves Jeferson Silva Ferreira , Dos Santos Igo Carvalho , Do Nascimento Eduardo Melo , Braga Francyane Tavares 
Published: November 2023

Objective: The present work aimed to evaluate the callogenesis of murici-pitanga in different explants and growth regulators. since this species has great medicinal, environmental and economic importance, however the cultivation process and extractivism make its propagation difficult. Therefore, in vitro cultivation provides conditions that can optimize its propagation. Among the techniques used in in vitro micropropagation, callogenesis allows the regeneration of tissues, organs or plants, becoming a cultivation alternative for the species under study.

Method: Explants from seedlings cultivated in vitro were inoculated in MS 1/2 medium with different types, concentrations and combinations of growth regulators, namely: zygotic embryos under 6-benzylaminopurine x α-naphthaleneacetic acid (BAP x ANA) (0.0 ; 11.1, 22.2 and 44.4 µM); leaf and stem segments under NAA (0.0; 13.42; 26.85 and 40.27 µM) and root and leaf segments under 2,4-dichlorophenoxyacetic acid (2,4-D) (0.0; 2. 26; 4.52; 9.05 and 18.10 µM), with subcultures in cell suspensions (0.0; 4.52; 9.05; 18.10 and 3620 µM) and callus growth curve (4. 52 µM).

Resultsandconclusion: The percentage of induction and mass of fresh callus matter were evaluated. The callogenesis of murici-pitanga occurs more efficiently in the root segment in a medium supplemented with 4.52 µM of 2,4-D. Where, the calluses presented friable characteristics, in addition to better averages of induction percentage and fresh matter mass. For cell suspension, a concentration of 4.52 µM of 2,4-D is indicated, and in the growth curve, the best period for callus subculture may occur on the 56th day of cultivation, established based on the callus growth pattern sigmoidal with three distinct phases. Therefore, the murici-pitanga can be regenerated through calluses originating from root segments.

Originality/value: Studies that address the in vitro propagation of murici-pitanga are scarce, and the present work reports significant results, with new explant options and different types of growth regulators to be used. In addition to advances in studies of callus subcultures with great potential for regeneration. These results become important, since the species needs techniques that facilitate its propagation, and could support future morphogenetic studies, obtaining secondary metabolites, in addition to establishing a regeneration protocol via somatic embryogenesis.
Volumetric Modeling in the Amapá National Forest
Authors: De Abreu Jadson Coelho , Aparício Perseu da Silva , Silva Wegliane Campelo , Da Costa Verena Holanda 
Published: November 2023

Theoretical framework: Volumetric models are a crucial tool for forest management, as they use them to estimate the total volume of the forest.

Objective: The study aimed to adjust a volumetric model to estimate commercial volume in a dense rainforest located in the municipality of Ferreira Gomes AP, Brazil.

Method: Cubing data from 103 sample trees, from 5 species, were used to adjust 7 volumetric models, 5 of which were linear and 2 were non-linear.

Results and discussion: After analysis, it was found that all models presented a good fit to the data, however the non-linear models presented the best statistics. Finally, the Schumacher and Hall model generated the best equation for estimating commercial volume in the Amapá national forest.

Implications of the research: There is a general equation to estimate the volume of commercial species in the Amapá national forest.

Originality/Value: Volume equations are essential for management plans in Amazonia, therefore, this is the first equation available for volume estimation in the Amapá national forest.
IMPLEMENTASI SOSTAC DALAM STRATEGI KOMUNIKASI MARKETING PUBLIC RELATIONS (STUDI DESKRIPTIF KUALITATIF PADA RUANG KREATIF GEDUNG DHARMA NEGARA ALAYA DENPASAR)
Authors: I.M. Bayu Mahardika  , I Dewa Ayu Hendrawathy Putri  , I Gusti Ngurah Pertu Agung  
Published: November 2023

Penelitian ini dilakukan untuk mengetahui komunikasi marketing public relations di Gedung Dharma Negara Alaya Denpasar. Sebagai jawaban atas program yang ditetapkan oleh pemerintah Kota Denpasar dalam wujud Ruang Kreatif Gedung Dharma Negara Alaya Denpasar. Permasalahan yang dikaji dari penelitian ini adalah: 1) Bagaimanakah implementasi SOSTAC dalam strategi komunikasi marketing public relationss pada ruang kreatif Gedung Dharma Negara Alaya Denpasar? 2) Bagaimanakah strategi komunikasi marketing public relationss pada ruang kreatif Gedung Dharma Negara Alaya Denpasar? 3) Bagaimanakah kiat-kiat komunikasi marketing public relationss ruang kreatif Gedung Dharma Negara Alaya Denpasar?
Dengan penelitian kualitatif deskriptif, hasil analisis dengan metode SOSTAC untuk strategi digital marketing dan strategi komunikasi marketing public relations. Setelah dianalisis dengan metode SOSTAC, kemudian masing-masing rumusan masalah dibedah dengan teori public relations, teori komunikasi persuasif, dan teori interaksionisme simbolik. Hasil penelitian menunjukkan bahwa, 1) Implementasi SOSTAC (Situation, Objective, Strategi, Tactic, Action, Control) telah sesuai dengan penerapan komunikasi yang dikalankan oleh public relations team, 2) Strategi komunikasi yang dilakukan secara persuasif dan edukatif sehingga menarik minat masyarakat, 3) Dharma Negara Alaya memiliki komitmen tinggi untuk implementasi standar pelayanan publik yang telah ditetapkan. Kesimpulan, pelaksanaan komunikasi marketing public relations sudah sesuai dengan prinsip dan hirarki organisasi, melaksanakan komunikasi publik denan baik, professional, dan sesuai dengan prosedur sebagaimana yang telah disimpulkan penliti.
Kata kunci: SOSTAC, Public Relations, Komunikasi Publik, Marketing
FAKTOR PENYEBAB TERJADINYA CAMPUR KODE BASA BALI DALAM PUPULAN CERPEN KUPU – KUPU KUNING NGINDANG DI CANDIDASA KARYA I KETUT SANDIYASA
Authors: Wardika I Made Arya 
Published: November 2023

ABSTRAK
Bahasa merupakan media utama yang digunakan oleh seluruh lapisan masyarakat. setiap bahasa akan mengalam peridiosasinya masing masing yang lambat laun akan di tinggalkan oleh penuturnya khusunya pada bahasa Bali. Sastra adalah ajaran atau pedoman yang baik bagi manusia dan merupakan bentuk seni kreatifitas dengan menggunakan bahasa sebagai media perantara. Kesusastraan Bali modern khususnya cerpen banyak bermunculan di kalangan masyarakat yang membawa banyak kebharuan Kebaharuan tersebut terlihat pada penggunaan bahasa yang banyak becampur dengan bahasa Indonesia dan bahasa inggris yang di sebut campur kode. Salah satunya kumpulan Cerpen Kupu Kupu Kuning Ngindang Di Candidasa Karya I Ketut Sandiyasa. Pada karya sastra ini banyak di temukan campur kode dalam penyampainnya. Salah satunya pada judul cerpen sertifikasi, yang secara utuh lebih banyak penggunaan bahasa Indonesia dibandingkan bahasa Bali. Dalam penelitian ini mekaji satu rumusan masalah yaitu; Apa faktor yang menyebabkan kemunculan campur kode dalam Pupulan Cerpen Kupu – Kupu Kuning Ngindang Di Candidasa Karya I Ketut Sandiyasa?. Rumusan masalah ini menggunakan teori sosiolinguistik dan teori pilihan bahasa. Metode yang di gunakan adalah wawancara, kepustakaan dan dokumentasi. Jenis data yang digunakan pada penelitian ini adalah deskriptif kualitatif. Hasil penelitain yang di peroleh dalam Campur Kode Basa Bali Dalam Pupulan Cerpen Kupu – Kupu Kuning Ngindang Di Candididasa asalah adanya 2 faktor yang mempengaruhi yaitu faktor intralinguistik dan faktor ekstralinguistik. Faktor intalinguistik merupakan faktor yang berasal dari kebahasaan itu sendiri sedangkan faktor ekstralinguistik meliputi faktor penutur, faktor tempat berbicara, faktor tujuan berbicara, serta faktor perkembangan zaman.
Kata kunci : Campur Kode, Cerpen, Faktor