bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell Membrane‐Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis‐Enhanced Photodynamic Immunotherapy
Authors: Chen Jian , Duan Zeyu , Deng Lidong , Li Lie , Li Qiyan , Qu Jinqing , Li Xiang , Liu Ruiyuan 
Published: February 2024

AbstractAn imbalance in reactive oxygen species (ROS) levels in tumor cells can result in the accumulation of lipid peroxide (LPO) which can induce ferroptosis. Moreover, elevated ROS levels in tumors present a chance to develop ROS‐based cancer therapeutics including photodynamic therapy (PDT) and ferroptosis. However, their anticancer efficacies are compromised by insufficient oxygen levels and inherent cellular ROS regulatory mechanism. Herein, a cell membrane‐targeting photosensitizer, TBzT‐CNQi, which can generate 1O2, •OH, and O2•− via type I/II process to induce a high level of LPO for potent ferroptosis and photodynamic therapy is developed. The FSP1 inhibitor (iFSP1) is incorporated with TBzT‐CNQi to downregulate FSP1 expression, lower the intracellular CoQ10 content, induce a high level of LPO, and activate initial tumor immunogenic ferroptosis. In vitro and in vivo experiments demonstrate that the cell membrane‐targeting type I/II PDT combination with FSP1 inhibition can evoke strong ICD and activate the immune response, which subsequently promotes the invasion of CD8+ T cells infiltration, facilitates the dendritic cell maturation, and decreases the tumor infiltration of tumor‐associated macrophages. The study indicates that the combination of cell membrane‐targeting type I/II PDT and FSP1 inhibition holds promise as a potential strategy for ferroptosis‐enhanced photodynamic immunotherapy of hypoxia tumors.
A Catalyst‐Like System Enables Efficient Perovskite Solar Cells
Authors: Yang Yuqian , Li Guodong , Zhao Lichen , Tan Pengju , Li Yu , Li Shunde , Tan Lina , Deng Chunyan , Wang Shibo , Zhao Zhenzhu , Yuan Chengjian , Ding Honghe , Chen Liang , Zhu Junfa , Guan Yong , Hou Cheng‐Hung , Tang Pengyi , Li Quiyang , Liu Hong , Yang Yingguo , Abate Antonio , Shyue Jing‐Jong , Wu Jihuai , Russell Thomas P. , Hu Qin 
Published: February 2024

AbstractHigh‐quality perovskite films are essential for achieving high performance of optoelectronic devices; However, solution‐processed perovskite films are known to suffer from compositional and structural inhomogeneity due to lack of systematic control over the kinetics during the formation. Here, the microscopic homogeneity of perovskite films is successfully enhanced by modulating the conversion reaction kinetics using a catalyst‐like system generated by a foaming agent. The chemical and structural evolution during this catalytic conversion is revealed by a multimodal synchrotron toolkit with spatial resolutions spanning many length scales. Combining these insights with computational investigations, a cyclic conversion pathway model is developed that yields exceptional perovskite homogeneity due to enhanced conversion, having a power conversion efficiency of 24.51% for photovoltaic devices. This work establishes a systematic link between processing of precursor and homogeneity of the perovskite films.
Selective Induction of Molecular Assembly to Tissue‐Level Anisotropy on Peptide‐Based Optoelectronic Cardiac Biointerfaces
Authors: Yao Ze‐Fan , Kuang Yuyao , Wu Hao‐Tian , Lundqvist Emil , Fu Xin , Celt Natalie , Pei Jian , Yee Albert F. , Ardoña Herdeline Ann M. 
Published: February 2024

AbstractThe conduction efficiency of ions in excitable tissues and of charged species in organic conjugated materials both benefit from having ordered domains and anisotropic pathways. In this study, a photocurrent‐generating cardiac biointerface is presented, particularly for investigating the sensitivity of cardiomyocytes to geometrically comply to biomacromolecular cues differentially assembled on a conductive nanogrooved substrate. Through a polymeric surface‐templated approach, photoconductive substrates with symmetric peptide‐quaterthiophene (4T)‐peptide units assembled as 1D nanostructures on nanoimprinted polyalkylthiophene (P3HT) surface are developed. The 4T‐based peptides studied here can form 1D nanostructures on prepatterned polyalkylthiophene substrates, as directed by hydrogen bonding, aromatic interactions between 4T and P3HT, and physical confinement on the nanogrooves. It is observed that smaller 4T‐peptide units that can achieve a higher degree of assembly order within the polymeric templates serve as a more efficient driver of cardiac cytoskeletal anisotropy than merely presenting aligned ‐RGD bioadhesive epitopes on a nanotopographic surface. These results unravel some insights on how cardiomyocytes perceive submicrometer dimensionality, local molecular order, and characteristics of surface cues in their immediate environment. Overall, the work offers a cardiac patterning platform that presents the possibility of a gene modification‐free cardiac photostimulation approach while controlling the conduction directionality of the biotic and abiotic components.
Phenothiazine Derivatives as Small‐Molecule Organic Cathodes with Adjustable Dropout Voltage and Cycle Performance
Authors: Gong Yanxiang , Zhang Weichao , Liu Zhenjiang , Fang Manman , Yang Jie , Wang Yunsheng , Gao Mingxue , Zhang Jun , Yang Quan‐Hong , Li Zhen 
Published: February 2024

AbstractCompared with conventional inorganic materials, organic electrodes are competitive candidates for secondary battery cathodes due to their resourcefulness, environmental friendliness, and cost‐effectiveness. Much effort is devoted at the level of chemical structure, while ignoring the impact of molecular aggregation on battery behavior. Herein, this work designs a series of organic molecules with two electrochemically active phenothiazine groups linked by different lengths of alkyl chain to regulate molecular symmetry and crystallinity. The results emphasize the equally important role of molecular aggregation and chemical structure for battery performance. Among them, 2PTZ‐C7H14|Li cell exhibits the most impressive cycle and rate performance. At the high rate of 50 C, it can still deliver a capacity of 63.4 mA h g−1 and 74.5% capacity retention after 10 000 cycles. Besides, the dropout voltage of 2PTZ‐C9H18|Li cell is only 52 mV, which is among the lowest reported for lithium‐organic batteries to the best of the author's knowledge.
Angle‐Independent Top‐Emitting Quantum‐Dot Light‐Emitting Diodes Using a Solution‐Processed Subwavelength Scattering–Capping Layer
Authors: Lee Taesoo , Lee Minhyung , Kim Kyuho , Lee Hyunkoo , Yoon Suk‐Young , Yang Heesun , Yu Sunkyu , Kwak Jeonghun 
Published: February 2024

AbstractOwing to the excellent optoelectronic properties of colloidal quantum dots (QDs), light‐emitting diodes based on QDs (QLEDs) have been considered one of the most promising electroluminescence (EL) devices for full‐color displays with a wide color gamut. Particularly, top‐emission device architecture has been of interest to both academia and industry, because of the advantages in light outcoupling, aperture ratios, and integration with conventional backplanes. In this structure, however, angle‐dependent color shifts originating from a variation in microcavity length are a critical issue that needs to be resolved. Here, a solution‐processed dual‐functional scattering–capping layer (SCPL) using ZnO nanoparticles on top‐emitting QLEDs with ZnSeTe/ZnSe/ZnS QDs to modulate the optical interference is presented. By precisely controlling the thickness of the SCPL, the EL intensity and spectrum can be redistributed to produce a uniform color from any viewing angle. It is discovered that, unlike conventional CPLs, the formation of random nanocracks and nanoclusters in the SCPL adds subwavelength light‐scattering capabilities, which promotes light extraction. The QLEDs with the solution‐processed SCPL exhibit a 44% increase in the maximum external quantum efficiency, with completely imperceptible angle‐dependent spectral shifts. The SCPL is expected to be applied to the development of high‐performance and next‐generation QLED displays.
A core–shell‐structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection
Authors: Kan Qihui , Song Yaping , Yao Yining , Zhang Jun , Xian He , Cheng Dan , Wang Yue , Mao Liang , Wang Meiyan , Yu Chengzhong 
Published: February 2024

AbstractBacterial infection is a major threat to public health. Nanotechnology offers a solution by combining nanomaterials with antibacterial agents. The development of an effective nanocomposite against drug‐resistant bacteria such as methicillin‐resistant Staphylococcus aureus (MRSA) is highly important yet challenging. Here, an anti‐MRSA core–shell structure is designed, containing antibacterial zeolitic imidazolate framework‐8 (ZIF‐8) as the core and bactericidal benzalkonium chloride (BAC) templated rough‐surface mesostructured silica nanocomposite (RMSN) as the shell. The resultant ZIF‐8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions, effective disruption of the bacterial membrane, generation of oxidative damage of bacterial DNA, leakage of intracellular components, and finally bacterial death. Furthermore, the synergistic antibacterial mechanisms lead to enhanced biofilm elimination performance. In addition, the ZIF‐8@RMSN‐modified band‐aid effectively combats MRSA infection in vivo. This work has provided a promising nanocomposite against MRSA‐related infections.
Data‐driven identification of crystallization kinetics
Authors: Nyande Baggie W. , Nagy Zoltan K. , Lakerveld Richard 
Published: February 2024

AbstractA novel data‐driven methodology is presented for developing mathematical models for crystallization processes. The data‐driven approach is based on the sparse identification of nonlinear dynamics (SINDy) method, which iterates between a partial least‐squares fit and a sparsity‐promoting step leading to the discovery of sparse interpretable models. The performance of the SINDy methodology is characterized for the identification of crystallization kinetics in a mixed tank operated in a continuous mode, the isothermal crystallization of lysozyme in a batch stirred tank and cooling crystallization of paracetamol. The SINDy method is robust against noise. Good agreement is obtained between the data‐driven model and the data obtained from crystallization experiments. The presented data‐driven approach can be attractive for modeling industrial crystallization processes where process analytical technology tools are available for the measurement of process variables but functional forms of kinetic expressions are unknown.
sp‐Carbon‐Conjugated Organic Polymer as Multifunctional Interfacial Layers for Ultra‐Long Dendrite‐Free Lithium Metal Batteries
Authors: Lu Xiao‐Meng , Cao Yingnan , Sun Yi , Wang Haichao , Sun Weiwei , Xu Yi , Wu Yang , Yang Chao , Wang Yong 
Published: February 2024

AbstractFatal issues in lithium metal anodes (LMA), such as detrimental lithium dendrites growth and fragile solid‐electrolyte interphase (SEI) during the Li plating/stripping process, often hinder the practical application of Li metal batteries (LMBs). Herein, cobalt‐coordinated sp‐carbon‐conjugated organic polymer (Co‐spc‐COP) is constructed as the protective layer for regulating the interface stability of LMA. The unique synergistic beneficial effect of organic functional groups (C≡C linkage, C=N units and aromatic rings) and Co sites not only regulate the Li+ coordination environment and rearrange Li+ concentration to facilitate its transport by optimizing the electronic density, enhancing the compatibility with electrolyte interface and supplying “external magnetic driving strategy”, but also strengthens the interfacial stiffness with high Young's modulus to better withstand the mechanical stress. These beneficial effects and relative underlying working mode and mechanism of uniform Li plating and rapid Li+ migration on the Co‐spc‐COP are also revealed by various in situ/ex situ experimental technologies and theory calculation. The Co‐spc‐COP‐based cell delivers an extraordinary lifespan of 6600 h and ultrahigh capacity retention of 78.3 % (111.9 mAh g−1) after 1000 cycles at 1 C. This demonstrated synergistic strategy in Co‐coordinated organic polymer may gain new insights to regulate the uniform and non‐dendritic deposition/dissolution behaviors for highly stable LMBs.
Orchid fruit and root movement analyzed using 2D photographs and a bioinformatics pipeline for processing sequential 3D scans
Authors: Pramanik Dewi , Vaskimo Lotta , Batenburg K. Joost , Kostenko Alexander , Droppert Kevin , Smets Erik , Gravendeel Barbara 
Published: February 2024

AbstractPremiseMost studies of the movement of orchid fruits and roots during plant development have focused on morphological observations; however, further genetic analysis is required to understand the molecular mechanisms underlying this phenomenon. A precise tool is required to observe these movements and harvest tissue at the correct position and time for transcriptomics research.MethodsWe utilized three‐dimensional (3D) micro–computed tomography (CT) scans to capture the movement of fast‐growing Erycina pusilla roots, and built an integrated bioinformatics pipeline to process 3D images into 3D time‐lapse videos. To record the movement of slowly developing E. pusilla and Phalaenopsis equestris fruits, two‐dimensional (2D) photographs were used.ResultsThe E. pusilla roots twisted and resupinated multiple times from early development. The first period occurred in the early developmental stage (77–84 days after germination [DAG]) and the subsequent period occurred later in development (140–154 DAG). While E. pusilla fruits twisted 45° from 56–63 days after pollination (DAP), the fruits of P. equestris only began to resupinate a week before dehiscence (133 DAP) and ended a week after dehiscence (161 DAP).DiscussionOur methods revealed that each orchid root and fruit had an independent direction and degree of torsion from the initial to the final position. Our innovative approaches produced detailed spatial and temporal information on the resupination of roots and fruits during orchid development.
A virtual library of small molecules mimicking dipeptides
Authors: Lim Victor Jun Yu , Gerber Hans‐Dieter , Schihada Hannes , Trinh Van Tuan , Hilger Daniel , Vázquez Olalla , Kolb Peter 
Published: February 2024

AbstractVirtual combinatorial libraries are prevalent in drug discovery due to improvements in the prediction of synthetic reactions that can be performed. This has gone hand in hand with the development of virtual screening capabilities to effectively screen the large chemical spaces spanned by exhaustive enumeration of reaction products. In this study, we generated a small‐molecule dipeptide mimic library to target proteins binding small peptides. The library was created based on the general idea of peptide synthesis, that is, amino acid mimics were reacted in silico to form the dipeptide mimics, yielding 2,036,819 unique compounds. After docking calculations, two compounds from the library were synthesized and tested against WD repeat‐containing protein 5 (WDR5) and histamine receptors H1–H4 to evaluate whether these molecules are viable in assays. The compounds showed the highest potency at the histamine H3 receptor, with Ki values in the two‐digit micromolar range.
Design, synthesis, and evaluation of dual‐target inhibitors for the treatment of Alzheimer's disease
Authors: Zhai Jingfang , Hao Canhua , Wang Xiaojing , Cao Yuexing , Pan Yinbo , Zhou Min , Sun Jie , Li Chuanyou 
Published: February 2024

AbstractAβ1−42 and acetylcholinesterase (AChE) are two key therapeutic targets for Alzheimer's disease (AD). The purpose of this study is to develop a dual‐target inhibitor that inhibits both of these targets by fusing the chemical structure of baicalein and donepezil. Among them, we modified the structure of baicalein to arylcoumarin, synthesized three kinds of structural compounds, and evaluated their biological activities. The results showed that compound 3b had the strongest inhibitory effect on AChE (IC50 = 0.05 ± 0.02 µM), which was better than those of donepezil and baicalein. In addition, compound 3b has a strong ability to inhibit the aggregation of Aβ1−42 and protect nerve cells, and it can also penetrate the blood–brain barrier well. Using a zebrafish behavioral analyzer test, it was found that compound 3b can alleviate the behavioral effects of AlCl3‐induced zebrafish larval movement retardation, which has a certain guiding significance for simulating the movement disorders of AD patients. In summary, compound 3b is expected to become a multifunctional agent for treating and alleviating the symptoms of AD patients.
Application of Na2CO3 as a Sacrificial Electrode Additive in Na‐ion Batteries to Compensate for the Sodium Deficiency in Na2/3[Fe1/2Mn1/2]O2
Authors: Matsuzaki Masayoshi , Tatara Ryoichi , Kubota Kei , Kuroki Kazutoshi , Hosaka Tomooki , Umetsu Kazuteru , Okada Nobuhiro , Komaba Shinichi 
Published: February 2024

AbstractOwing to their high discharge capacities, P2‐type transition metal layered oxides have attracted attention for use as positive electrode materials in Na‐ion batteries. However, owing to the Na‐deficient compositions of these oxides, additional Na+ must be supplied using a Na‐metal negative electrode to attain a high capacity in a half‐cell configuration. In this study, solid Na2CO3 powder was introduced into the P2−Na2/3Fe1/2Mn1/2O2 composite positive electrode as a sacrificial salt to compensate for the Na deficiency. Na+ was supplied through the electrochemical oxidative decomposition of Na2CO3 during the initial charging process; the decomposition mechanism responsible for this process was investigated in detail. Online electrochemical mass spectrometry confirmed that Na2CO3 was oxidatively decomposed in combination with the decomposition of the ethylene carbonate electrolyte. This reaction produced CO2, wherein the carbon source was derived from both Na2CO3 and the electrolyte. Consequently, Na+ supplementation improved the reversible capacity of the Na‐ion full cell. This study offers practical insights and a mechanistic understanding of the pre‐doping technique for Na‐free negative electrodes. This approach also compensates for the irreversible reductive capacity in a process that can be easily applied to practical sodium‐ and lithium‐ion batteries and capacitors.
From structure to function: Harnessing the ionic conductivity of covalent organic frameworks
Authors: Liu Cong‐Xue , Hwang Soomin , Woo Hyerin , Lee Eunsung , Park Sarah S. 
Published: February 2024

AbstractRapid advancements in energy storage technology, driven by a growing demand for energy storage devices, underscore the crucial need to comprehend ionic conduction behavior. Consequently, intensive research on high‐performance ionic conductors becomes imperative. Covalent organic frameworks (COFs) have emerged as invaluable materials in the realm of solid‐state or quasi‐solid‐state ion‐conduction, leveraging their unique properties such as significant porosity, tunability, and robust physicochemical durability. These distinctive attributes position COFs as promising candidates for the development of electrodes, electrolytes, and separator materials characterized by high capacities, rapid ion transport, and electrochemical stability. This review provides insights into COFs as ionic conductors, discusses recent advancements in COF‐based energy storage devices, and explores the influence of structural functionalization, pore size engineering, and dimensional regulation on ionic conduction. Moreover, the review aims to deepen understanding and pave the way for future advancements in the utilization of COFs within energy storage technologies.
Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis
Authors: Inomata Yushi , Kuroha Masatake , Shimoyama Yusuke , Naito Takeo , Moroi Rintaro , Shiga Hisashi , Kakuta Yoichi , Karasawa Hideaki , Onuma Shinobu , Kinouchi Yoshitaka , Masamune Atsushi 
Published: February 2024

AbstractBackground and PurposeColorectal cancer progression from adenoma to cancer is a time‐intensive process; however, the interaction between normal fibroblasts (NFs) with early colorectal tumors, such as adenomas, remains unclear. Here, we analyzed the response of the microenvironment during early tumorigenesis using co‐cultures of organoids and NFs.Materials and MethodsColon normal epithelium, adenoma, cancer organoid, and NFs were established and co‐cultured using Transwell inserts. Microarray analysis of NFs was performed to identify factors expressed early in tumor growth. Immunostaining of clinical specimens was performed to localize the identified factor. Functional analysis was performed using HCT116 cells. Serum DKK1 levels were measured in patients with colorectal cancer and adenoma.ResultsColorectal organoid–NF co‐culture resulted in increased organoid diameter and cell viability in normal epithelial and adenomatous organoids but not in cancer organoids. Microarray analysis of NFs revealed 18 genes with increased expression when co‐cultured with adenoma and cancer organoids. Immunohistochemical staining revealed DKK1 expression in the tumor stroma from early tumor growth. DKK1 stimulation reduced HCT116 cell proliferation, while DKK1 silencing by siRNA transfection increased cell proliferation. Serum DKK1 level was significantly higher in patients with advanced cancer and adenoma than in controls. Serum DKK1 level revealed area‐under‐the‐curve values of 0.78 and 0.64 for cancer and adenoma, respectively.ConclusionThese findings contribute valuable insights into the early stages of colorectal tumorigenesis and suggest DKK1 as a tumor suppressor. Additionally, serum DKK1 levels could serve as a biomarker to identify both cancer and adenoma, offering diagnostic possibilities for early‐stage colon tumors.The present study has a few limitations. We considered using DKK1 as a candidate gene for gene transfer to organoids and NFs; however, it was difficult due to technical problems and the slow growth rate of NFs. Therefore, we used cancer cell lines instead. In addition, immunostaining and ELISA were based on the short‐term collection at a single institution, and further accumulation of such data is desirable. As described above, most previous reports were related to advanced cancers, but in this study, new findings were obtained by conducting experiments on endoscopically curable early‐stage tumors, such as adenomas.