bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient perspectives on recall period and response options in patient‐reported outcome measures for chronic rhinosinusitis symptomatology: An international multi‐centered study
Authors: Sedaghat Ahmad R. , Derbarsegian Armo , Yu Victor T. , Alsayed Ahmed , Bitner Benjamin F. , Yeom Brian , Liu David T. , Schneider Sven , Adams Sarah M. , Houssein Firas A. , Walters Zoe A. , Tripathi Siddhant , Walker Victoria L. , Singerman Kyle W. , Meier Josh C. , Kim Raymond , Kuan Edward C. , Alsaleh Saad , Phillips Katie M. 
Published: October 2023

AbstractBackgroundExisting patient‐reported outcome measures (PROMs) for chronic rhinosinusitis (CRS) use a variety of recall periods and response scales to assess CRS symptom burden. Global perspectives of CRS patients regarding optimal recall periods and response scales for CRS PROMs are unknown.MethodsThis was a multi‐center, cross‐sectional study recruiting 461 CRS patients from sites across the United States, Saudi Arabia, New Zealand, and Austria. Participants chose which CRS symptom recall period (1 day, 2 weeks, 1 month, >1 month) was most reflective of their current disease state and upon which to best base treatment recommendations (including surgery). Participants also chose which of six response scales (one visual analogue scale and five Likert scales ranging from four to eight items) was easiest to use, understand, and preferred.ResultsA plurality of participants (40.0%) felt their CRS symptoms’ current state was best reflected by a 1‐month recall period. However, most patients (56.9%) preferred treatment recommendations to be determined by symptoms experienced over a >1 month period. The four‐ and five‐item Likert scales were the easiest to understand (26.0% and 25.4%, respectively) and use (23.4% and 26.7%, respectively). The five‐item (26.4% rating it most preferred and 70.9% rating it preferred) and four‐item Likert (22.3% rating it most preferred and 56.4% rating it preferred) response scales were most preferred.ConclusionFuture PROMs for CRS should consider assessment of symptoms over a 1‐month period and use a four‐ or five‐item Likert response scale to reflect global patient preferences. These findings also inform interpretation of current CRS PROMs.
Histopathologic features of biologic therapy nonresponders in chronic rhinosinusitis with nasal polyposis
Authors: Baird Ali M. , Masliah Jamie , Filip Peter , Talati Vidit , Brown Hannah J. , Owen Grant , Khalife Sarah , Papagiannopoulos Peter , Gattuso Paolo , Batra Pete S. , Tajudeen Bobby A. 
Published: October 2023

AbstractBackgroundBiologics are effective for chronic rhinosinusitis with nasal polyposis (CRSwNP) by reducing type 2 inflammation. Nonresponders often require functional endoscopic sinus surgery (FESS) and represent a challenging population potentially due to non‐type 2 pathophysiology. This study characterizes the histopathologic features of biologic nonresponders.MethodsA retrospective review of 257 CRSwNP patients undergoing FESS was conducted. The biologic nonresponder group included patients with prior biologic therapy who exhibited persistent symptoms and polyp burden. Those with CRSwNP not prescribed biologic therapy were selected as controls. Demographics, comorbidities, and structured histopathology consisting of 13 variables were collected.ResultsOf 257 CRSwNP patients, 20 were on biologics prior to FESS. Fourteen patients (70.0%) received dupilumab, one (5.0%) received mepolizumab, one (5.0%) received omalizumab, and four (20.0%) tried multiple biologics. The mean age for the biologic nonresponder group was 45.8 years compared to 50.4 years for the controls. Nonresponders had a significantly increased incidence of reduced tissue eosinophilia, defined as <5 per high power field (55% vs. 31.2%, p = 0.044) and increased basement membrane thickening (100% vs. 78.1%, p = 0.019). The remaining 11 variables did not reach statistical significance.ConclusionHistopathologic analysis of biologic nonresponders demonstrates decreased eosinophilia and thickened basement membranes. These findings, particularly low tissue eosinophils, are consistent with a non‐type 2 CRSwNP that may be recalcitrant to biologic therapies. Histopathologic analysis done in conjunction with FESS may aid clinicians in understanding response to biologic therapies in patients with CRSwNP who have persistent symptom burden necessitating FESS.
Correlation of Broad Absorption Band with Small Singlet‐Triplet Energy Gap in Organic Photovoltaics
Authors: Fan Baobing , Gao Wei , Zhang Rui , Kaminsky Werner , Tang Lingxiao , Lin Francis R. , Wang Yiwen , Fan Qunping , Ma Wei , Gao Feng , Jen Alex K.‐Y. 
Published: October 2023

AbstractOrganic photovoltaics (OPV) are one of the most effective ways to harvest renewable solar energy, with the power conversion efficiency (PCE) of the devices soaring above 19 % when processed with halogenated solvents. The superior photocurrent of OPV over other emerging photovoltaics offers more opportunities to further improve the efficiency. Tailoring the absorption band of photoactive materials is an effective way to further enhance OPV photocurrent. However, the field has mostly been focusing on improving the near‐infrared region photo‐response, with the absorption shoulders in short‐wavelength region (SWR) usually being neglected. Herein, by developing a series of non‐fullerene acceptors (NFAs) with varied side‐group conjugations, we observe an enhanced SWR absorption band with increased side‐group conjugation length. The underpinning factors of how molecular structures and geometries improve SWR absorption are clearly elucidated through theoretical modelling and crystallography. Moreover, a clear relationship between the enhanced SWR absorption and reduced singlet‐triplet energy gap is established, both of which are favorable for the OPV performance and can be tailored by rational structure design of NFAs. Finally, the rationally designed NFA, BO‐TTBr, affords a decent PCE of 18.5 % when processed with a non‐halogenated green solvent.
Dearomative Ring‐Fused Azafulleroids and Carbazole‐Derived Metallofullerenes: Reactivity Dictated by Encapsulation in a Fullerene Cage
Authors: Liu Tong‐Xin , Wang Xin , Xia Shilu , Chen Muqing , Li Mingjie , Yang Panting , Ma Nana , Hu Ziqi , Yang Shangfeng , Zhang Guisheng , Wang Guan‐Wu 
Published: October 2023

AbstractHerein, we report divergent additions of 2,2′‐diazidobiphenyls to C60 and Sc3N@Ih‐C80. In stark contrast to that of the previously reported bis‐azide additions, the unexpected cascade reaction leads to the dearomative formation of azafulleroids 2 fused with a 7‐6‐5‐membered ring system in the case of C60. In contrast, the corresponding reaction with Sc3N@Ih‐C80 switches to the C−H insertion pathway, thereby resulting in multiple isomers, including a carbazole‐derived [6,6]‐azametallofulleroid 3 and a [5,6]‐azametallofulleroid 4 and an unusual 1,2,3,6‐tetrahydropyrrolo[3,2‐c]carbazole‐derived metallofullerene 5, whose molecular structures have been unambiguously determined by single‐crystal X‐ray diffraction analyses. Among them, the addition type of 5 is observed for the first time in all reported additions of azides to fullerenes. Furthermore, unexpected isomerizations from 3 to 5 and from 4 to 5 have been discovered, providing the first examples of the isomerization of an azafulleroid to a carbazole‐derived fullerene rather than an aziridinofullerene. In particular, the isomerism of the [5,6]‐isomer 4 to the [5,6]‐isomer 5 is unprecedented in fullerene chemistry, contradicting the present understanding that isomerization generally occurs between [5,6]‐ and [6,6]‐isomers. Control experiments have been carried out to rationalize the reaction mechanism. Furthermore, representative azafulleroids have been applied in organic solar cells, thereby resulting in improved power conversion efficiencies.
Mild Hydrogenation of 2‐Furoic Acid by Pt Nanoparticles Dispersed in a Hierarchical ZSM‐5 Zeolite
Authors: Pornsetmetakul Peerapol , Maineawklang Narasiri , Prasertsab Anittha , Salakhum Saros , Hensen Emiel J. M. , Wattanakit Chularat 
Published: October 2023

AbstractHydrogenation of biobased compounds can add value to platform molecules obtained from biomass refining. Herein, we explore the hydrogenation of 2‐furoic acid (2‐furancarboxylic acid, FCA), a derivative of furfural, with H2 generated in situ by NaBH4 hydrolysis at ambient conditions. Nearly complete conversion of FCA was obtained with tetrahydrofuroic acid (THFA) and 5‐hydroxyvaleric acid (5‐HVA) as the only two reaction products over Pt nanoparticles supported on hierarchical ZSM‐5. Small Pt nanoparticles (2 to 3 nm) were stabilized by ZSM‐5 nanosheets. At an optimized Pt loading, the Pt nanoparticles can catalyze the hydrolysis of NaBH4 and the subsequent hydrogenation of FCA with the assistance of Brønsted acid sites. Nanostructuring ZSM‐5 into nanosheets and its acidity contributes to the stability of the dispersed Pt nanoparticles. Deactivation due to NaBO2 deposition on the Pt particles can be countered by a simple washing treatment. Overall, this approach shows the promise of mild hydrogenation of biobased feedstock coupled with NaBH4 hydrolysis.
Trajectories for Lithium‐Ion Battery Cost Production: Can Metal Prices Hamper the Deployment of Lithium‐Ion Batteries?
Authors: Orangi Sina , Manjong Nelson Bunyui , Clos Daniel Perez , Usai Lorenzo , Stokke Burheim Odne , Strømman Anders Hammer 
Published: October 2023

AbstractCost‐savings in lithium‐ion battery production are crucial for promoting widespread adoption of Battery Electric Vehicles and achieving cost‐parity with internal combustion engines. This study presents a comprehensive analysis of projected production costs for lithium‐ion batteries by 2030, focusing on essential metals. It explores the complex interplay of factors, including economies of scale, R&D innovations, market dynamics, and metal price trends. The findings highlight the significant role of R&D innovations and economies of scale in substantial cost reductions by 2030, with projected ranges of 21–28 % and 25–37 %, respectively. However, potential cost escalations due to elevated metal prices, particularly for nickel‐cobalt‐containing chemistries, are also cautioned. To address these challenges, the study proposes a strategic shift towards robust Lithium‐Iron‐Phosphate (LFP) chemistry to mitigate cost pressures and meet predefined cost targets. Moreover, by analyzing medium or low metal price trends, the study reveals the potential for significant cost savings, with exceptional scenarios demonstrating up to a remarkable 65 % reduction in costs. Given the broad range of cost likelihoods, the study underscores the importance of vertical integration and international cooperation in managing the essential metals supply chain securely. The research has profound implications for policymakers and industry decision‐makers, providing valuable insights into the lithium‐ion battery industry.
Holistic assessment of Brazil's bioenergetic potential
Authors: de Sousa Laura Vieira Maia , Silva Lora Electo Eduardo , de Lisboa Fábio Cordeiro , Filho Fernando Bruno Dovichi , del Olmo Oscar Almazan 
Published: October 2023

AbstractThere is an urgent need for energy sources with lower environmental impacts to dispose of waste generated by human activities. In this context, a holistic analysis of energy use of waste from agricultural and forestry activities, animal excreta, urban solid waste and sewage, waste from the pulp and paper industry and charcoal in Brazil is presented. Based on a bibliographic review, the current Brazilian panorama is presented in figures giving, a vision of national potential for harnessing bioenergy from this theoretical and technical potential. The QGIS3.24.2 Tisler geoprocessing tool was used to generate potentiality maps from census data of microregions and municipalities available in the IBGE database (2022) and in the Geocentric Reference System for the Americas (SIRGAS 2000). The results of map analysis by micro‐regions of the primary energy from agricultural residues highlight sugar cane, corn and soybeans crops, followed by wastewater and animal excreta. They stood out amont the studied sources of biomass with technical potentials of 53.17, 15.23 and 6.81 GW, respectively. With these results, it is concluded that Brazil could enable around 75 GW installed power, reusing all biomass, potentially 12.5 PJ, without considering the 16 GW already installed from sugarcane and paper black liquor plants.
Combined spinal and epidural anaesthesia for open radical cystectomy: A controlled study
Authors: Galletta Maria , De Pasquale Maria , Buttitta Alessandro , Viganò Silvia , Mucciardi Giuseppe , Giannarini Gianluca , Ficarra Vincenzo 
Published: October 2023

AbstractObjectivesTo evaluate the feasibility of loco‐regional anaesthesia and to compare perioperative outcomes between loco‐regional and standard general anaesthesia in patients with bladder cancer undergoing open radical cystectomy (ORC).Patients and MethodsA single‐surgeon cohort of 60 consecutive patients with bladder cancer undergoing ORC with an enhanced recovery after surgery protocol between May 2020 and December 2021 was analysed. A study group of 15 patients operated on under combined spinal and epidural anaesthesia was compared with a control group of 45 patients receiving standard general anaesthesia. Intraoperative outcomes were haemodynamic stability, estimated blood loss, intraoperative red blood cell transfusion rate, and anaesthesia time. Postoperative outcomes were pain assessment 24 h after surgery, time to mobilisation, return to oral diet, time to bowel function recovery, length of stay and rate of 90‐day complications.ResultsNo patients required conversion from loco‐regional to general anaesthesia. All patients in both groups were haemodynamically stable. No significant differences between groups were observed for all other intraoperative outcomes, except for a shorter anaesthesia time in the study versus control group (250 vs. 290 min, p = 0.01). Pain visual score 24 h after surgery was significantly lower in the study versus control group (0 vs. 2, p < 0.001). No significant differences were observed for all other postoperative outcomes, with a comparable time to bowel function recovery (5 days in each group for stool passage), and 90‐day complication rate (46.6% vs. 42.2% for the study vs. control group, p = 0.76).ConclusionOur exploratory, controlled study confirmed the feasibility, safety and effectiveness of a pure loco‐regional anaesthesia in patients with bladder cancer undergoing ORC. No significant differences were observed in intra‐ and postoperative outcomes between loco‐regional and general anaesthesia, except for a significantly shorter anaesthesia time and greater pain reduction in the early postoperative period for the former.
Confirmatory structural validation and refinement of the Recurrent Urinary Tract Infection Symptom Scale
Authors: Newlands Abigail F. , Kramer Melissa , Roberts Lindsey , Maxwell Kayleigh , Price Jessica L. , Finlay Katherine A. 
Published: October 2023

AbstractObjectivesTo confirm the structural validity of the Recurrent Urinary Tract Infection Symptom Scale (RUTISS), determining whether a bifactor model appropriately fits the questionnaire's structure and identifying areas for refinement. Used in conjunction with established clinical testing methods, this patient‐reported outcome measure addresses the urgent need to validate the patient perspective.Patients and methodsA clinically and demographically diverse sample of 389 people experiencing recurrent UTI across 37 countries (96.9% female biological sex, aged 18–87 years) completed the RUTISS online. A bifactor graded response model was fitted to the data, identifying potential items for deletion if they indicated significant differential item functioning (DIF) based on sociodemographic characteristics, contributed to local item dependence or demonstrated poor fit or discrimination capability.ResultsThe final RUTISS comprised a 3‐item symptom frequency section, a 1‐item global rating of change scale and an 11‐item general ‘rUTI symptom and pain severity’ subscale with four sub‐factor domains measuring ‘urinary symptoms’, ‘urinary presentation’, ‘UTI pain and discomfort’ and ‘bodily sensations’. The bifactor model fit indices were excellent (root mean square error of approximation [RMSEA] = 0.041, comparative fit index [CFI] = 0.995, standardised root mean square residual [SRMSR] = 0.047), and the mean‐square fit statistics indicated that all items were productive for measurement (mean square fit indices [MNSQ] = 0.64 – 1.29). Eighty‐one per cent of the common model variance was accounted for by the general factor and sub‐factors collectively, and all factor loadings were greater than 0.30 and communalities greater than 0.60. Items indicated high discrimination capability (slope parameters > 1.35).ConclusionThe 15‐item RUTISS is a patient‐generated, psychometrically robust questionnaire that dynamically assesses the patient experience of recurrent UTI symptoms and pain. This brief tool offers the unique opportunity to enhance patient‐centred care by supporting shared decision‐making and patient monitoring.
Transporter mining and metabolic engineering of Escherichia coli for high‐level D‐allulose production from D‐fructose by thermo‐swing fermentation
Authors: Guo Qiang , Zhang Ya‐Xing , Zheng Ling‐Jie , Zhang Meng‐Jun , Zheng Shang‐He , Chen Wei‐Xiang , Fan Li‐Hai , Zheng Hui‐Dong 
Published: October 2023

AbstractD‐Allulose is an ultra‐low‐calorie sweetener with broad market prospects in the fields of food, beverage, health care, and medicine. The fermentative synthesis of D‐allulose is still under development and considered as an ideal route to replace enzymatic approaches for large‐scale production of D‐allulose in the future. Generally, D‐allulose is synthesized from D‐fructose through Izumoring epimerization. This biological reaction is reversible, and a high temperature is beneficial to the conversion of D‐fructose. Mild cell growth conditions seriously limit the efficiency of producing D‐allulose through fermentation. FryABC permease was identified to be responsible for the transport of D‐allulose in Escherichia coli by comparative transcriptomic analysis. A cell factory was then developed by expression of ptsG‐F, dpe, and deletion of fryA, fruA, manXYZ, mak, and galE. The results show that the newly engineered E. coli was able to produce 32.33 ± 1.33 g L−1 of D‐allulose through a unique thermo‐swing fermentation process, with a yield of 0.94 ± 0.01 g g−1 on D‐fructose.
Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
Authors: Yang Yu , Shi Xian‐quan , Chen Guang , Qian Lin‐xue 
Published: October 2023

AbstractPurposePancreatic cancer is one of the most aggressive malignant tumors with poor prognosis. High‐intensity focused ultrasound (HIFU) is an effective and safe treatment option for advanced pancreatic cancer, however, the survival time of patients after the treatment was different. So, the purpose of this study was to evaluate the relationship between the high‐risk characteristics and prognosis of unresectable pancreatic cancer after HIFU treatment.Patients and MethodsThis prospective study included 30 patients with unresectable pancreatic cancer who received HIFU at Beijing Friendship Hospital. Data on patients' tumor size, pain scores, peripheral blood lymphocyte subsets, CA19‐9 and contrast enhanced ultrasound (CEUS) features were collected to assess the relationship with overall survival (OS) after HIFU.ResultsThe median OS from the start of HIFU treatment was 159 days, 95% confidence interval (95% CI): 108–210. The levels of pain were determined by visual analogue scale (VAS) score, and the quartile of the score decreased from 6 (2, 7) to 4 (2, 5) immediately after one session of the treatment (p = 0.001). The diagnostic model showed that high post VAS score and decreasing of peripheral CD4+ T cells were significantly correlated with poor prognosis (p < 0.05), and showed good discrimination ability (AUC = 0.848, 95% CI = 0.709–0.987).ConclusionHIFU can effectively relieve pain in patients with unresectable pancreatic cancer. Post treatment VAS and change of peripheral CD4+ T cells are independent risk factors affecting the prognosis in patients with unresectable pancreatic cancer after HIFU treatment.
Peripheral insulin resistance is early, progressive, and correlated with cachexia in Walker‐256 tumor‐bearing rats
Authors: de Morais Hely , Bôas Suéllen Kathiane Fernandes Vilas , de Souza Camila O. , Miksza Daniele Romani , Moreira Carolina C. L. , Kurauti Mirian Ayumi , Silva Flaviane de F. , Cassolla Priscila , Silva Francemilson Goulart da , Limiere Leticia Cristina , Grassiolli Sabrina , Bazotte Roberto B. , de Souza Helenir M. 
Published: October 2023

AbstractInsulin (INS) resistance is often found in cancer‐bearing, but its correlation with cachexia development is not completely established. This study investigated the temporal sequence of the development of INS resistance and cachexia to establish the relationship between these factors in Walker‐256 tumor‐bearing rats (TB rats). INS hepatic sensitivity and INS resistance‐inducing factors, such as free fatty acids (FFA) and tumor necrosis factor‐α (TNF‐α), were also evaluated. Studies were carried out on Days 2, 5, 8, and/or 12 after inoculation of tumor cells in rats. The peripheral INS sensitivity was assessed by the INS tolerance test and the INS hepatic sensitivity in in situ liver perfusion. TB rats with 5, 8, and 12 days of tumor, but not 2 days, showed decreased peripheral INS sensitivity (INS resistance), retroperitoneal fat, and body weight, compared to healthy rats, which were more pronounced on Day 12. Gastrocnemius muscle wasting was observed only on Day 12 of tumor. The peripheral INS resistance was significantly correlated (r = −.81) with weight loss. Liver INS sensitivity of TB rats with 2 and 5 days of tumor was unchanged, compared to healthy rats. TB rats with 12 days of tumor showed increased plasma FFA and increased TNF‐α in retroperitoneal fat and liver, but not in the gastrocnemius, compared to healthy rats. In conclusion, peripheral INS resistance is early, starts along with fat and weight loss and before muscle wasting, progressive, and correlated with cachexia, suggesting that it may play an important role in the pathogenesis of the cachectic process in TB rats. Therefore, early correction of INS resistance may be a therapeutic approach to prevent and treat cancer cachexia.
Selection of Highly Specific DNA Aptamer for the Development of QCM‐Based Arsenic Sensor
Authors: Kumar Sandeep , Singh Poonam , Verma Sanjay Kumar 
Published: October 2023

AbstractHeavy metal arsenic is a water pollutant that affects millions of lives worldwide. A novel aptamer candidate for specific and sensitive arsenic detection was identified using Graphene Oxide‐SELEX (GO‐SELEX). Eleven rounds of GO‐SELEX were performed to screen As(III) specific sequences. The selected aptamer sequences were evaluated for their binding affinity. The dissociation constant of the best aptamer candidate, As‐06 was estimated by fluorescence recovery upon target addition, and it was found to be 8.15 nM. A QCM‐based biosensing platform was designed based on the target‐triggered release of aptamer from the QCM electrode. An rGO‐SWCNT nanocomposite was adsorbed on the gold surface, and the single‐stranded probe was stacked on the rGO‐CNT layer. Upon addition of the target to the solution, a concentration‐dependent release of the ssDNA probe was observed and recorded as the change in the electrode frequency. The developed QCM sensor showed a dynamic linear range from 10 nM to 100 nM and a low detection limit of 8.6 nM. The sensor exhibited excellent selectivity when challenged with common interfering anions and cations.