bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Nonformal Education Management Accounting Program in The East Jakarta Region
Authors: Tri Hartadi Galih , Fitriana Sitorus Onny 
Published: February 2025

Education is a conscious and planned effort to create a learning atmosphere that allows students to have spiritual potential, self-control, personality, develop intelligence, noble character and skills. Education cannot be separated from humans and plays an important role in developing individual intelligence and abilities so that their development runs well. Non-formal education programs have the same important position as formal education in development. According to Law Number 20 of 2003, the management of non-formal education in Indonesia is also in the spotlight because there are still problems occurring in the field, such as lack of coordination, scarcity of professional educators, and low learning motivation. The purpose of this research is to find out how planning, organizing and evaluating institutions carry out accounting programs. The research method uses qualitative methods. The research subject is addressed to participants, instructors and managers. The research results show that management is carried out well, this refers to planning, organizing and evaluating well.
A PENILAIAN KINERJA FISIK SUNGAI SEBAGAI UPAYA PERBAIKAN BADAN SUNGAI
Authors: Khairiyah Miftahul , Agoes Herliyani Farial , Hayati Fitriani 
Published: February 2025

Sungai Pahari yang terletak di Desa Betung, Kabupaten Tanah Bumbu merupakan sungai yang dapat dikatakan kurang produktif karena terjadinya berbagai kerusakan di sepanjang sungai seperti longsor, penyempitan palung sungai, penumpukan sampah, pendangkalan, serta rusaknya prasarana sungai dan pengelolaan sumber daya air yang kurang tepat yang mengakibatkan terjadinya pencemaran air. Sebagai upaya perbaikan diperlukan identifikasi kondisi di lapangan agar dapat menentukan arah perbaikan yang diperlukan, melalui penilaian kinerja fisik sungai dilakukan berdasarkan Surat Edaran No. 05/SE/D/2016 tentang Operasi dan Pemeliharaan Prasarana Sungai serta Pemeliharaan Sungai. Hasil penilaian dapat disimpulkan terdapat 1000 m daerah sungai yang dikategorikan dalam rekomendasi Korektif dengan usulan perencanaan bangunan bronjong sepanjang bantaran sungai, dan 1500 m yang lain dikategorikan dalam rekomendasi Preventif dengan usulan pemeliharaan pengerukan tahunan dasar sungai, pembersihan ranting dan rumput liar, serta perbaikan prasarana sungai yang mengalami kerusakan. Pengeloaan sumber daya air yang bersumber dari sungai Pahari belum terlaksana sesuai dengan PP No. 38 Tahun 2011.
Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: Etiology, Clinical Presentation, and Management
Authors: Bellaire Christopher P. , Paulson Ambika E. , Ani Chinonso F. , Benn Lancelot , Carroll Austin H. , Mesfin Addisu 
Published: February 2025

» Ossification of the posterior longitudinal ligament (OPLL) is a hyperostotic condition that results in ectopic bone formation and calcification of the posterior longitudinal ligament.» OPLL can present in any race/ethnicity but historically has been reported in the East Asian population.» OPLL predisposes patients to spinal cord injury in the setting of minor trauma.» Asymptomatic patients typically can be managed nonoperatively. Surgical treatment is reserved for patients presenting with myelopathy and worsening radiculopathy that has not responded to conservative treatment.» The decision to use anterior, posterior, or combined anterior-posterior approaches should be an individualized decision that considers the degree of OPLL pathology, K-line imaging findings, and other patient-specific risk factors.
Despoblación, envejecimiento y masculinización en Álava (España): una reflexión a partir del análisis de las evidencias empíricas
Authors: Porcal-Gonzalo María C. 
Published: February 2025

Este estudio pretende realizar una reflexión sobre la despoblación rural y su relación con los procesos de envejecimiento y masculinización, a partir del análisis de la incidencia de esos fenómenos en un territorio concebido como laboratorio (Álava, País Vasco) y de su evolución fundamentalmente en el siglo XXI. Se analiza, primero, la despoblación en su contexto territorial y temporal, resaltando los contrastes espaciales y los cambios de tendencia tras la pandemia COVID-19. Tras ello, se indaga en la pervivencia de estructuras demográficas frágiles en las áreas rurales. Se ha adoptado una perspectiva geodemográfica, concretada en un análisis multiescalar que ha descendido desde el nivel provincial hasta las entidades singulares de población. Se ha demostrado la utilidad del análisis inframunicipal para poner en resalte los desequilibrios territoriales y la heterogeneidad de los espacios rurales. Se confirma que las áreas rurales con mayor atonía demográfica han seguido mostrando comportamientos regresivos –salvo alguna excepción– al tiempo que se han consolidado procesos de dispersión residencial en municipios superiores a 2000 habitantes, que han mejorado el tradicional desequilibrio del sistema de asentamientos de Álava. Se constata el ascenso y la generalización territorial del envejecimiento y también el acusado desajuste de género existente en las edades adultas derivado de la escasez de mujeres.
Improved Reservoir Porosity Estimation Using an Enhanced Group Method of Data Handling with Differential Evolution Model and Explainable Artificial Intelligence
Authors: Mkono Christopher N. , Chuanbo Shen , Mulashani Alvin K. , Abelly Elieneza N. , Kasala Erasto E. , Shanghvi Eric R. , Emmanuely Baraka L. , Mokobodi Thabiso 
Published: February 2025

Summary
Reservoir characterization is critical to the oil and gas industry, influencing field development, production optimization, hydraulic fracturing, and reserves estimation decisions. Accurately estimating porosity is crucial for reservoir characterization, well planning, and production optimization in the oil and gas industry. Traditional porosity determination methods, such as porosimetry, geostatistical, and core analysis, often involve complex geological and geophysical models, which are expensive and time-consuming. This study used the integrated machine learning and optimization model of differential evolution (DE) with group method of data handling (GMDH-DE) to estimate the porosity using integrated well log and core data from the Mpyo oil field, Uganda. The GMDH-DE demonstrates superior performance compared with conventional GMDH, support vector regression (SVR), and random forest (RF), achieving a coefficient of determination (R2) of 0.9925 and a root mean square error (RMSE) of 0.0017 during training, an R² of 0.9845 with an RMSE of 0.0121 during testing, and when validated the R2 was 0.9825 with RMSE of 0.00018. A key novelty of this work is the integration of Shapley additive explanations (SHAP), which provides an interpretable analysis of the model’s input features. SHAP reveals that bulk density (RHOB) and neutron porosity (NPHI) are the most critical parameters for porosity estimation, offering valuable insight into features importance. The proposed GMDH-DE model and SHAP analysis represent a novel and independent approach for accurate porosity estimation and interpretability, significantly enhancing the efficiency and reliability of hydrocarbon exploration and development.
Balancing exploration and exploitation in genetic algorithm with a novel selection operator
Authors: Rafique Fahad , Cui Hengjian 
Published: February 2025

Abstract

The genetic algorithm (GA) is a widely recognized optimization technique for addressing complex and NP-hard problems; however, its effectiveness is often hampered by issues such as premature convergence and population diversity. The selection operator, which determines the probability of individuals being chosen for reproduction, significantly influences its performance. This study presents a novel selection operator, which is specifically designed to strike a balance between selection pressure and the preservation of population diversity. At the first stage, we derived the mathematical properties and assessed the sampling accuracy using Pearson’s chi-square test. For global investigation, we test its performance on benchmark TSPLIB instances and a real-world dataset of Pakistan's city coordinates in the context of the traveling salesman problem (TSP). The results indicate that the newly proposed operator either outperforms or equals the performance of other operators across key metrics, demonstrating superior stability as the dataset size increases. These findings suggest that our operator presents a promising solution for large-scale optimization challenges, such as TSP and other real-world applications.
The Influence of Mitophagy and Apoptosis on The Embryo Development in Kartagener and Globozoospermia Cases
Authors: KÜTÜK DUYGU , ÖNER ÇAĞRI , AKÇAY BERKAY , OLCAY İBRAHİM ORÇUN , ÇOLAK ERTUĞRUL , SELAM BELGİN 
Published: February 2025

Abstract

In this case study, we aimed to detect the gene expression profiles in two rare male infertility syndromes. The first syndrome is Globozoospermia which occurs via detecting acrosomal-free spherical sperm. Another rare and genetic syndrome is known as primary ciliary dyskinesia, Kartagener Syndrome which is caused by mutations that affect the motility of cilia. We aimed to identify the role of apoptosis and mitophagy genetic markers in embryonic waste culture medium of Globozoospermia and Kartagener Syndrome cases. Waste embryo culture medium samples of Globoospermia and Kartagener patients were collected. Total RNAs were isolated and MFN1, MFN2, Cyt C and p53 gene expressions were determined by using RT-PCR. KS sample with developing embryos have the lowest apoptotic pathway activity compared to both arrest KS and NR samples (p<0.001).
Although there is a genetic component to about half of cases of infertility, many genetic reasons of infertility in humans are still unknown. Over the past two decades, the discovery of gene variants related with infertility in patients has been made easier by the development of high-throughput sequencing tools.
Hyperglycemia induces histological abnormalities and dysregulates angiotensin-converting enzymes and inflammatory signaling in zebrafish brain: Possible relationship with memory impairment
Authors: Claro¹ Mariana Torri , Santos¹ Matheus Mülling dos , de Macedo¹ Gabriel Teixeira , Müller¹ Talise Ellwanger , Ferreira¹ Sabrina Antunes , Ajayi Babajide Oluwaseun , Rocha¹ João Batista Teixeira da , Barbosa Nilda de Vargas 
Published: February 2025

Abstract

Dysregulation of renin-angiotensin system (RAS), through the actions of angiotensin-converting enzymes significantly impacts inflammatory responses. Recent studies have demonstrated the relevance of RAS in Coronavirus Disease 2019 (COVID-19), where outcomes worsen in diabetic patients. We investigate the effects of hyperglycemia on RAS components and inflammatory gene expression in adult zebrafish brain. Hyperglycemia was induced by exposing zebrafish to a 111 mM glucose solution for 14 days. Behavioral tasks were conducted to evaluate learning/memory and anxiety-like behavior. After fasting, blood glucose levels were measured, and brain collected for histological and q-RT-PCR analyses. Exposure to glucose resulted in a significant hyperglycemic state, inducing anxiety-like phenotypes and impairing learning and memory. These alterations were followed by an upregulation of ace and a downregulation of ace2 brain transcripts. Additionally, there was an increase in the transcript levels of the gene adam17a. Furthermore, hyperglycemia increased the transcript levels of il-6, il-10, and il-1β, along with a decrease in rela transcripts. Several histological abnormalities were found in the telencephalon, cerebellum and optic tectum of hyperglycemic fish, including neuronal and synaptic loss, gliosis, edema and necrosis. Collectively, our results demonstrate that hyperglycemia significantly disrupts behavioral and cognitive functions in adult zebrafish. These conditions correlate with dysregulated expression of critical components of RAS and inflammatory markers, suggesting a potential neuroinflammatory pathway that may underlie the observed neurodegenerative effects in brain. The dysregulation of angiotensin-converting enzymes signaling, which play critical roles in the pathophysiology of COVID-19, may exacerbate inflammation and contribute to the neurological complications associated with the disease.
Comparison between surgical outcomes of the minipterional and pterional approaches in hypertensive intracerebral hemorrhage patients
Authors: Gunnarut Ittipon , Buakate Kritsada 
Published: February 2025

Abstract

Background Intracerebral hemorrhage is a condition which entails high rates of morbidity and mortality. Effective interventions range from conservative treatment to surgical management. The minipterional approach is an alternative, minimally invasive method used to treat various lesions. This report aims to compare the clinical outcomes and length of hospital stay resulting from the minipterional and pterional approaches in basal ganglion hemorrhage.
Results Demographic Data: The age of patients who underwent the pterional approach was significantly higher than that of the minipterional group.
Clinical Outcomes: The minipterional group had better postoperative Glasgow Coma Scores and shorter length of hospital stay than their counterparts in the conventional group.
Conclusion The minipterional approach is an effective alternative for treating hypertensive basal ganglion hemorrhage, yielding shorter hospital stays and better outcomes.
Tuning Cyanide Coordination Electronic Structure Enables Stable Prussian Blue Analogues for Sodium-ion Batteries
Authors: Zuo Pengjian , Wang Yuanheng , Yan Jiaxin , Xie Bingxing , Meng Yan , Fu Chuankai , Kong Fanpeng , Wang Xingyu , Zhou Qingjie , Chen Xin , Li Jianting , Du Chunyu , Wang Liguang 
Published: February 2025

Abstract

Prussian blue analogues (PBAs) with 3D cyanide-bridged frameworks exhibit significant potential as cathode materials for sodium-ion batteries. However, the dissolution of transition metals and structural distortion often lead to structural instability, causing serious capacity degradation during cycling. Fundamental understanding and tuning the coordination electronic structure to mitigate PBAs instability remain challenging. Herein, we address these challenges by modulating the local electronic structure surrounding high-spin metals to optimize the cyanide coordination environment, enabling a uniform electron distribution within the crystal structure. The resulting uniform electronic structure enhances the reactivity of the transition metals, which helps to achieve 95.7% of the theoretical capacity. More importantly, the regulation of electronic displacement within the cyanide coordination environment significantly improves the crystal structural stability, yielding an impressive capacity retention of 91.7% after 1000 cycles. These findings provide new insights into the coordination structural chemistry of PBAs and offer valuable guidance for the development of advanced cathode materials for sodium-ion batteries.
Effects of Losartan, Rapamycin, Doxycycline and Botulinum Toxin A: An Experimentally Induced Urethral Trauma Model in Rats
Authors: Baltik Mücahit , Ergün Osman , Koşar Pınar Aslan , Onaran İbrahim , Tepebaşı Muhammet Yusuf 
Published: February 2025

Abstract

Purpose
To assess the antifibrotic efficacy of losartan, rapamycin, doxycycline, and botulinum toxin A (BTX-A) in an experimentally induced urethral trauma rat model.
Methods
Sixty male rats were assigned to six groups; sham (n = 10), stricture (n = 10), losartan (n = 10), rapamycin (n = 10), doxycycline (n = 10), and BTX-A (n = 10). The sham group was exposed to only a penoscrotal incision. In the other groups, 10 watt electrocoagulation with a duration of one second was applied at 5 mm intervals to three points on the urethra. Ten units of BTX-A (0.5 ml) was injected into the submucosal tissue following electrocoagulation in the BTX-A group. Losartan (30 mg/kg/day), doxycycline (10 mg/kg/day), and rapamycin (2 mg/kg/day) were administered for 14 days postoperatively by oral gavage to the other three groups. The animals were sacrificed on the 14th days, and their urethral tissues were removed.
Results
All treatment groups exhibited superiority over the stenosis groups with improvements in fibrosis, inflammation, vascular congestion, epithelial degeneration, and submucosal hemorrhage (p < 0.001). The treatment groups emerged as superior to the stenosis group with decreased interleukin-1β expression (p < 0,001). The mean gene values improved significantly in all treatment groups compared with those in the stenosis group (p < 0.001).
Conclusion
All treatment groups showed reduced fibrosis. This research is the first to use losartan and doxycycline in urethral stenosis. Further data are needed regarding the use of these drugs for urethral stenosis.
Isorhapontigenin is a novel potential therapeutic agent for lung cancer： evidence from network pharmacology, bioinformatics, molecular docking and in vitro experiments
Authors: Wu Zhiyu , Hou Chengyu , Zhu Qiulin , Huang Zixia , Lu Zesheng , Shen Chunhui , Wang Zhenhui , Liu Yanzhong , Kang Yanfen , Wang JiYong 
Published: February 2025

Abstract

Background: Isorhapontigenin is an effective active ingredient in rheum officinale, which has been reported to have anti-tumor effects. However, its effect and molecular mechanism on non-small cell lung cancer are still unclear. Methods: Firstly, potential therapeutic targets of Isorhapontigenin against non-small cell lung cancer were obtained through network pharmacology analysis. Secondly, bioinformatics analysis was conducted to identify key targets and potential signaling pathway mechanisms based on the obtained potential targets. Then, evaluate the binding ability between Isorhapontigenin and key targets using computer molecular docking strategies. Finally, in vitro cell experiments were conducted to verify the effects and related targets of Isorhapontigenin on non-small cell lung cancer cells. Results: 104 drug targets and 6688 disease targets were acquired from SwissTarget prediction, BATMAN-TCM, STITCH and Genecards databases.79 potential therapeutic targets were identified through analysis based on online Venn website and PPI interaction analysis was performed on these targets to ultimately obtain 55 key targets. GO and KEGG analysis revealed that Isorhapontigenin mainly act on cell proliferation and cycle processes and PI3K/RELA/Cellcyle pathways to against non-small cell lung cancer. Computer molecular docking confirmed that Isorhapontigenin can bind to cell proliferation, cycle related proteins (CCND1, CDK2, PIK3CA, RELA). CCK-8 detection revealed that Isorhapontigenin significantly inhibited the proliferation of PC9 lung cancer cells, Moreover, RT-PCR detection showed that Isorhapontigenin downregulated the expression of CCND1, CDK2, PIK3CA and RELA genes. CCND1, CDK2, PIK3CA and RELA are highly expressed in NSCLC tissues. Overall survival analysis of patients indicated that key genes in the PIK3CA and NF-κBp65 signaling pathway significantly affected overall survival. Conclusion: Our research has found that Isorhapontigenin can effectively against non-small cell lung cancer, and this effect may be achieved by inhibiting cell proliferation and cycle progression mediated by the PIK3CA/NF-KB signaling pathway. Isorhapontigenin is a new potential therapeutic agent for lung cancer.
Do We Dream About the People We See Every Day?: A Longitudinal Test of the Social Simulation Theory of Dreaming
Authors: Balch John , Raider Rachel , Reed Chanel , McNamara Patrick 
Published: February 2025

Abstract

Researchers have established that dreams are intensely social and populated by diverse characters, including important figures from the dreamer’s daily life. This study examines the types of characters that appeared in participant dreams over two weeks. We found that the majority of dreams include strangers in addition to known individuals, and that personality measures impact the likelihood of dreaming about different types of people. Appearance of known individuals from daily life in dreams was assessed by comparing dream reports to the core support networks of participants and daily diaries. We found that relationship-specific variables and daily interaction were important predictors of the likelihood of support network dream appearances. While daily interaction generally increases the likelihood of dream appearances, this effect is reversed for important family members like parents or siblings, indicating that dreams may play a compensatory role in maintaining relationships with close others when they are not present.
Do fistula flow rate and fistula location have any effects on heart failure developing in patients with arteriovenous fistula?
Authors: Yümün Gündüz , Donbaloğlu Mehmet Okan , Gürkan Selami , Gür Özcan , Demirkıran Aykut 
Published: February 2025

Abstract

Background
This study aims to explore the effects of arteriovenous fistula locations in the arm and fistula flow rates on the potential development of heart failure in patients with arteriovenous fistula (AVF).
Material and Methods
A total of 116 patients with AVF due to chronic kidney disease (CKD) were retrospectively reviewed between January 2022 and August 2022. Fifty-six patients with distal AVFs and 60 with proximal AVFs were compared in terms of demographic, clinical, and echocardiographic (ECHO) characteristics. Fistula flow rates were assessed using Doppler ultrasonography (DUS), while cardiac parameters were evaluated with ECHO. The correlation between fistula location and cardiac parameters was analyzed using ROC analysis.
Results
The mean AVF blood flow rate (Qa) was 1.47 (0.57–2.9) L/min for proximal fistulas and 0.85 (0.52–2.3) L/min for distal fistulas. There were statistically significant differences between the proximal and distal AVF groups regarding cardiac index (CI), cardiac output (CO), and cardiopulmonary recirculation (CPR) values (P < 0.001). According to the New York Heart Association (NYHA) classification, Class III can be categorized as high cardiac output failure (HCOF), as CI was calculated at 6.87 ± 1.65 L/min/m² (4.7–9.4), Qa at 2.60 L/min (2.1–2.9), and CO at 8.08 ± 0.69 L/min.
Conclusions
When heart failure develops in patients with AVF, underlying heart disease should not be the sole factor considered. Proximal high-flow AVFs, in particular, may contribute to heart failure development and warrant careful monitoring.