bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registration of ‘PVL03’ rice
Authors: Angira Brijesh , Linscombe Steven D. , Webster Eric P. , Webster Connor , Harrell Dustin L. , Groth Donald E. , Dalla‐Lana Felipe , Zaunbrecher Richard E. , Dartez Valerie , Williams Brady , Theunissen Brent , Famoso Adam 
Published: January 2024

Abstract‘PVL03’ (Reg. no. CV‐159, PI 699656), a Provisia (BASF) long‐grain rice (Oryza sativa L.) cultivar, was developed by the Louisiana State University Agricultural Center at the H. Rouse Caffey Rice Research Station near Crowley, LA, and approved for release in 2020. PVL03 is the third rice cultivar released as part of the Provisia Rice System with resistance to Provisia herbicide, containing the active ingredient quizalofop‐p‐ethyl, an AACase (group 1) herbicide. PVL03 was derived from the cross ‘PVL01’/‘Catahoula’. Testing in the Provisia preliminary yield trial in 2018 and the multi‐location trial in 2019 indicated good yield potential and favorable agronomic characteristics. In 2020, PVL03 was evaluated in commercial advanced replicated trials across six locations in Louisiana. Four high‐yielding commercial cultivars were included as checks: ‘PVL02’, PVL01, ‘CL153’, and ‘Cheniere’. The average grain yield of PVL03 was 9.6 t ha−1 compared with 8.0 t ha−1 for PVL02, 8.1 t ha−1 for PVL01, 9.8 t ha−1 for CL153, and 9.1 t ha−1 for Cheniere. PVL03 was shorter than the previous Provisia cultivar, PVL02. The milled grain length was longer than that of PVL02, with a length‐to‐width ratio of 3.0. It has a typical US long‐grain rice cooking quality with intermediate amylose and gelatinization temperature. PVL03 is moderately susceptible to sheath blight and moderately resistant to leaf blast and bacterial panicle blight.
Assessing Lattice Thermal Conductivity of Topological Insulator Bi2Se3 by Raman Thermometry
Authors: Kurian Elavunkel Vipin , Das Soumendra Kumar , Padhan Prahallad 
Published: January 2024

Lattice thermal conductivity (κL) of the hexagon‐shaped nanocrystals cluster of Bi2Se3, prepared by the hot‐injection technique using nontoxic solvents, is studied. From the temperature‐dependent Raman spectra of Bi2Se3 nanocrystals, the average Debye temperature (θD) and Gruneisen parameter (γ) are calculated by adopting the bond‐order–length–strength correlation theory. The average room temperature κL of Bi2Se3 nanocrystals evaluated from the Slack model using θD and γ is ≈1.1 Wm−1K−1. The κL of Bi2Se3 nanocrystals is larger than out‐of‐plane κL (≈0.4 Wm−1K−1) but close to the in‐plane κL (≈1.4 Wm−1K−1) simulated using the Boltzmann transport equation for phonon with three‐phonon scatterings. Nanostructuring introduces grain boundaries in the Bi2Se3 that block the long mean free path of phonons physically, reduces the phonon mean free path, and decreases the κL. The anisotropic phonon scattering introduced by the weak van der Waals force between adjacent quintuple layers in the out‐of‐plane direction, in addition to the acoustic–optical phonon scattering and anharmonicity, hinders the efficient transport of thermal energy in the Bi2Se3 and results in a lower κL. By utilizing materials with anisotropic thermal conductivity, thermoelectric devices can be designed to preferentially conduct heat in specific directions while minimizing heat loss in others.
Design of UHPC prestressed girders for shear
Authors: Foster Stephen J. , Bentz Evan 
Published: January 2024

AbstractBreakthrough technology of ultra‐high‐performance concrete (UHPC) introduced in the 1990s exhibits several exceptional mechanical properties that are advantageous in elements of bridge applications. Extensive research has aimed to industrialize UHPC and develop design models. This paper investigates several design models for shear, including a unified approach with that of conventional concrete based on the modified compression field theory (MCFT). An experimental database of UHPC prestressed concrete girders subjected to shear failure is compiled to evaluate model accuracy and a reliability study is conducted to establish appropriate safety factors. The analysis demonstrates that the proposed MCFT‐based model aligns well with experimental results, exhibiting a suitable level of conservatism for design. A reliability assessment of a typical prestressed girder designed according to Canadian Standards Association building and bridge loadings is performed, resulting in a structural reliability evaluation against a target reliability index. The study recommends specific strength reduction and safety factors for design approaches using UHPC.
A comparison of cardiovascular disease, cancer, mortality, and Graves' ophthalmopathy following treatment for hyperthyroidism: A Bayesian network meta‐analysis
Authors: Liu Xiaodong , Wong Carlos K. H. , Wu Tingting , Chan Wendy W. L. , Woo Yu Cho , Lam Cindy L. K. , Lang Brian H. H. 
Published: January 2024

AbstractObjectivesThis network meta‐analysis aimed to evaluate the association of anti‐thyroid drugs (ATD), radioactive iodine (RAI), and thyroidectomy with subsequent outcomes in patients with newly‐diagnosed hyperthyroidism.MethodsThe Ovid Medline, Ovid Embase, and Cochrane Library databases were searched for observational studies and randomized controlled trials. Included studies were published on or before 1st May 2022 involving at least two of the treatments among ATD, RAI, and thyroidectomy for hyperthyroidism. Pairwise comparisons and Bayesian network meta‐analysis were used to estimate hazard ratios (HRs) and their credible interval (CrI) of outcomes, including cardiovascular disease (CVD), cancer, overall mortality, and Graves' ophthalmopathy (GO).ResultsA total of 22 cohort studies with 131,297 hyperthyroidism patients were included. Thyroidectomy was associated with lower risks of mortality and GO than ATD (HR = 0.54, 95% CrI: 0.31, 0.96; HR = 0.31, 95% CrI: 0.12, 0.64) and RAI (HR = 0.62, 95% CrI: 0.41, 0.95; HR = 0.18, 95% CrI: 0.07, 0.35). RAI had a higher risk of GO (HR = 1.70, 95% CrI: 1.02, 2.99) than ATD treatment.ConclusionsThis Bayesian network meta‐analysis indicated that thyroidectomy was associated with lower risks of mortality and GO in newly‐diagnosed hyperthyroid patients compared to ATD and RAI. Relative to ATD, RAI therapy increased the risk of GO.
Glial cell alterations in diabetes-induced neurodegeneration
Authors: Llorián-Salvador María , Cabeza-Fernández Sonia , Gomez-Sanchez Jose A. , de la Fuente Alerie G. 
Published: January 2024

AbstractType 2 diabetes mellitus is a global epidemic that due to its increasing prevalence worldwide will likely become the most common debilitating health condition. Even if diabetes is primarily a metabolic disorder, it is now well established that key aspects of the pathogenesis of diabetes are associated with nervous system alterations, including deleterious chronic inflammation of neural tissues, referred here as neuroinflammation, along with different detrimental glial cell responses to stress conditions and neurodegenerative features. Moreover, diabetes resembles accelerated aging, further increasing the risk of developing age-linked neurodegenerative disorders. As such, the most common and disabling diabetic comorbidities, namely diabetic retinopathy, peripheral neuropathy, and cognitive decline, are intimately associated with neurodegeneration. As described in aging and other neurological disorders, glial cell alterations such as microglial, astrocyte, and Müller cell increased reactivity and dysfunctionality, myelin loss and Schwann cell alterations have been broadly described in diabetes in both human and animal models, where they are key contributors to chronic noxious inflammation of neural tissues within the PNS and CNS. In this review, we aim to describe in-depth the common and unique aspects underlying glial cell changes observed across the three main diabetic complications, with the goal of uncovering shared glial cells alterations and common pathological mechanisms that will enable the discovery of potential targets to limit neuroinflammation and prevent neurodegeneration in all three diabetic complications. Diabetes and its complications are already a public health concern due to its rapidly increasing incidence, and thus its health and economic impact. Hence, understanding the key role that glial cells play in the pathogenesis underlying peripheral neuropathy, retinopathy, and cognitive decline in diabetes will provide us with novel therapeutic approaches to tackle diabetic-associated neurodegeneration.
Graphical abstract
Efficacy of Warm Acupuncture Therapy Combined with Kegel Exercise on Postpartum Pelvic Floor Dysfunction in Women
Authors: Dai Jinling , Jin Zhu , Zhang Xiaojin , Lian Feng , Tu Jie 
Published: January 2024

Abstract
Introduction and hypothesis
The objective was to observe the clinical efficacy of warm acupuncture combined with Kegel exercise in treating postpartum pelvic floor dysfunction in women.

Methods
A total of 70 primiparous women with postpartum pelvic floor muscle (PFM) injury were randomly divided into a combination group (n = 35, receiving warm acupuncture at Zhibian (BL54) acupoint and Kegel exercise) and a sham control group (n = 35, receiving sham warm acupuncture and Kegel exercise). Both groups were treated three times a week for 4 consecutive weeks. The recovery of PFM strength and changes in Urethral Rotation Angle (URA), Bladder Neck Descent (BND), and Retrovesical Angle (RVA) in pelvic floor ultrasound reports, the scores of pelvic floor dysfunction-related questionnaires, and the efficacy of urinary incontinence treatment of the two groups were compared before and after treatment.

Results
After treatment, the recovery rates of type I and II PFM strength, pelvic floor ultrasound parameters, pelvic floor dysfunction-related scale scores, and urinary incontinence treatment efficacy in the combination group were significantly better than those in the sham control group (p < 0.05).

Conclusion
Warm acupuncture combined with Kegel exercise can significantly improve PFM strength and promote the recovery of postpartum pelvic floor function in women.
Trans-equatorial migration links oceanic frontal habitats across the Pacific Ocean: year-round movements and foraging activity of a small gadfly petrel
Authors: Clay Thomas A. , Brooke M. de L. 
Published: January 2024

AbstractGadfly petrels are among the widest-ranging birds and inhabit oceanic regions beyond the legislative protection of national jurisdictions (the High Seas). Detailed information on breeding phenology, at-sea distributions, and habitat requirements is crucial for understanding threats and designing conservation measures for this highly threatened group. We tracked 10 Stejneger’s petrels Pterodroma longirostris, endemic to Isla Alejandro Selkirk, Juan Fernández Islands in the southeast Pacific Ocean, with geolocator-immersion loggers over two years to examine year-round movements, phenology, habitat use, and activity patterns. Birds conducted round-trip trans-equatorial migrations of 54,725 km to the northwest Pacific Ocean between Hawaii and Japan. Across the boreal summer, birds followed the c. 1000 km northward movement of the North Pacific Transition Zone Chlorophyll Front, before their return migration which took a long detour south toward New Zealand before heading east at 40–50°S, presumably benefitting from Antarctic circumpolar winds. To our knowledge, a comparable triangular migration is unique among seabirds. During the pre-laying exodus, birds traveled southwest to the Sub-Antarctic Front, and unlike congeners, there was no evidence of sexual segregation. Foraging areas during incubation were similar to pre-laying, with trips lasting 13 d and taking birds up to 4810 km southwest of the colony. Petrels spent > 75% of their time flying during breeding and migration, yet flight activity was substantially lower during non-breeding, presumably due to flight feather molt. Birds spent 87% of their time at sea within the High Seas and their apparent preference for oceanic frontal regions demonstrates the importance of protecting these remote habitats.
High-angular resolution diffusion imaging generation using 3d u-net
Authors: Suzuki Yuichi , Ueyama Tsuyoshi , Sakata Kentarou , Kasahara Akihiro , Iwanaga Hideyuki , Yasaka Koichiro , Abe Osamu 
Published: January 2024

Abstract
Purpose
To investigate the effects on tractography of artificial intelligence-based prediction of motion-probing gradients (MPGs) in diffusion-weighted imaging (DWI).

Methods
The 251 participants in this study were patients with brain tumors or epileptic seizures who underwent MRI to depict tractography. DWI was performed with 64 MPG directions and b = 0 s/mm2 images. The dataset was divided into a training set of 191 (mean age 45.7 [± 19.1] years), a validation set of 30 (mean age 41.6 [± 19.1] years), and a test set of 30 (mean age 49.6 [± 18.3] years) patients. Supervised training of a convolutional neural network was performed using b = 0 images and the first 32 axes of MPG images as the input data and the second 32 axes as the reference data. The trained model was applied to the test data, and tractography was performed using (a) input data only; (b) input plus prediction data; and (c) b = 0 images and the 64 MPG data (as a reference).

Results
In Q-ball imaging tractography, the average dice similarity coefficient (DSC) of the input plus prediction data was 0.715 (± 0.064), which was significantly higher than that of the input data alone (0.697 [± 0.070]) (p < 0.05). In generalized q-sampling imaging tractography, the average DSC of the input plus prediction data was 0.769 (± 0.091), which was also significantly higher than that of the input data alone (0.738 [± 0.118]) (p < 0.01).

Conclusion
Diffusion tractography is improved by adding predicted MPG images generated by an artificial intelligence model.
[68 Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis
Authors: Unterrainer Lena M. , Eismann Lennert , Lindner Simon , Gildehaus Franz-Josef , Toms Johannes , Casuscelli Jozefina , Holzgreve Adrien , Kunte Sophie C. , Cyran Clemens C. , Menold Paula , Karl Alexander , Unterrainer Marcus , Ledderose Stephan T. , Stief Christian G. , Bartenstein Peter , Kretschmer Alexander , Schulz Gerald B. 
Published: January 2024

Abstract
Introduction
[68 Ga]Ga-FAPI-46 PET/CT is a novel hybrid imaging method that previously showed additional diagnostic value in the assessment of distant urothelial carcinoma lesions. We hypothesized that patients with bladder cancer benefit from [68 Ga]Ga-FAPI-46 PET/CT prior to radical cystectomy for locoregional lymph node staging.

Materials and methods
Eighteen patients underwent [68 Ga]Ga-FAPI-46 PET/CT for evaluation of lymph node (LN) status in predefined LN regions. Two hundred twenty-nine intraoperatively removed LN served as histopathological reference standard.

Results
Urothelial carcinoma (UC) spread was found in ten LN in seven different regions (14.3%). Hereby, [68 Ga]Ga-FAPI-46 PET/CT was positive in four out of seven regions (57.1%) and showed significantly increased FAPI uptake compared to non-pathological regions. In the remaining three out of seven (42.9%) regions, [68 Ga]Ga-FAPI-46 PET/CT was rated negative since no pathological increased FAPI uptake was detected or the proximity of the urinary tract prevented a differentiation from physiological uptake. CT was inconspicuous in these three regions. In total, two FAP-positive LN regions were found without histopathological counterpart. Overall, sensitivity, specificity, positive predictive value, and negative predictive value were 57.1%, 95.2%, 66.7%, and 93.0% for PET imaging.

Conclusion
In summary, this innovative [68 Ga]Ga-FAPI-46 PET/CT method showed high specificity and negative predictive value in patients with bladder UC with a future potential to optimize therapy planning.
Molecular image–guided surgery in gynaecological cancer: where do we stand?
Authors: Pisano Giusi , Wendler Thomas , Valdés Olmos Renato A. , Garganese Giorgia , Rietbergen Daphne D. D. , Giammarile Francesco , Vidal-Sicart Sergi , Oonk Maaike H. M. , Frumovitz Michael , Abu-Rustum Nadeem R. , Scambia Giovanni , Rufini Vittoria , Collarino Angela 
Published: January 2024

Abstract
Purpose
The aim of this review is to give an overview of the current status of molecular image–guided surgery in gynaecological malignancies, from both clinical and technological points of view.

Methods
A narrative approach was taken to describe the relevant literature, focusing on clinical applications of molecular image–guided surgery in gynaecology, preoperative imaging as surgical roadmap, and intraoperative devices.

Results
The most common clinical application in gynaecology is sentinel node biopsy (SNB). Other promising approaches are receptor-target modalities and occult lesion localisation. Preoperative SPECT/CT and PET/CT permit a roadmap for adequate surgical planning. Intraoperative detection modalities span from 1D probes to 2D portable cameras and 3D freehand imaging.

Conclusion
After successful application of radio-guided SNB and SPECT, innovation is leaning towards hybrid modalities, such as hybrid tracer and fusion of imaging approaches including SPECT/CT and PET/CT. Robotic surgery, as well as augmented reality and virtual reality techniques, is leading to application of these innovative technologies to the clinical setting, guiding surgeons towards a precise, personalised, and minimally invasive approach.
Ziv-aflibercept plus pembrolizumab in patients with advanced melanoma resistant to anti-PD-1 treatment
Authors: Baginska Joanna , Nau Allison , Gomez Diaz Ilana , Giobbie-Hurder Anita , Weirather Jason , Vergara Juliana , Abrecht Charlotte , Hallisey Margaret , Dennis Jenna , Severgnini Mariano , Huezo Julia , Marciello Isabella , Rahma Osama , Manos Michael , Brohl Andrew S. , Bedard Philippe L. , Renouf Daniel J. , Sharon Elad , Streicher Howard , Ott Patrick A. , Buchbinder Elizabeth I. , Hodi F. Stephen 
Published: January 2024

Abstract
Background
Vascular endothelial growth factor is associated with reduced immune response and impaired anti-tumor activity. Combining antiangiogenic agents with immune checkpoint inhibition can overcome this immune suppression and enhance treatment efficacy.

Methods
This study investigated the combination of ziv-aflibercept anti-angiogenic therapy with pembrolizumab in patients with advanced melanoma resistant to anti-PD-1 treatment. Baseline and on-treatment plasma and PBMC samples were analyzed by multiplex protein assay and mass cytometry, respectively.

Results
In this Phase 1B study (NCT02298959), ten patients with advanced PD-1-resistant melanoma were treated with a combination of ziv-aflibercept (at 2–4 mg/kg) plus pembrolizumab (at 2 mg/kg), administered intravenously every 2 weeks. Two patients (20%) achieved a partial response, and two patients (20%) experienced stable disease (SD) as the best response. The two responders had mucosal melanoma, while both patients with SD had ocular melanoma. The combination therapy demonstrated clinical activity and acceptable safety, despite the occurrence of adverse events. Changes in plasma analytes such as platelet-derived growth factor and PD-L1 were explored, indicating potential alterations in myeloid cell function. Higher levels of circulating CXCL10 in non-responding patients may reflect pro-tumor activity. Specific subsets of γδ T cells were associated with poor clinical outcomes, suggesting impaired γδ T-cell function in non-responding patients.

Conclusions
Although limited by sample size and follow-up, these findings highlight the potential of the combination of ziv-aflibercept antiangiogenic therapy with pembrolizumab in patients with advanced melanoma resistant to anti-PD-1 treatment and the need for further research to improve outcomes in anti-PD-1-resistant melanoma.

Trial registration number
NCT02298959.
Immobilization of Thermoplasma acidophilum Glucose Dehydrogenase and Isocitrate Dehydrogenase Through Enzyme-Inorganic Hybrid Nanocrystal Formation
Authors: Oshima Shusuke , Oku Yuri , T.sriwong Kotchakorn , Kimura Yutaro , Matsuda Tomoko 
Published: January 2024

AbstractThe development of green catalysts, specifically biocatalysts, is crucial for building a sustainable society. To enhance the versatility of biocatalysts, the immobilization of enzymes plays a vital role as it improves their recyclability and robustness. As target enzymes to immobilize, glucose dehydrogenases and carboxylases are particularly important among various kinds of enzymes due to their involvement in two significant reactions: regeneration of the reduced form of coenzyme required for various reactions, and carboxylation reactions utilizing CO2 as a substrate, respectively. In this study, we immobilized Thermoplasma acidophilum glucose dehydrogenase (TaGDH) and T. acidophilum isocitrate dehydrogenase (TaIDH) using a previously reported method involving the formation of enzyme-inorganic hybrid nanocrystals, in the course of our continuing study focusing on carboxylation catalyzed by the free form of TaGDH and TaIDH. Subsequently, we investigated the properties of the resulting immobilized enzymes. Our results indicate the successful immobilization of TaGDH and TaIDH through the formation of hybrid nanocrystals utilizing Mn2+. The immobilization process enhanced TaIDH activity, up to 211%, while TaGDH retained 71% of its original activity. Notably, the immobilized TaGDH exhibited higher activity at temperatures exceeding 87 °C than the free TaGDH. Moreover, these immobilized enzymes could be recycled. Finally, we successfully utilized the immobilized enzymes for the carboxylation of 2-ketoglutaric acid under 1 MPa CO2. In conclusion, this study represents the first immobilization of TaGDH and TaIDH using the hybrid nanocrystal forming method. Furthermore, we achieved significant activity enhancement of TaIDH through immobilization and demonstrated the recyclability of the immobilized enzymes.
Variation Among Japanese Miso Breweries in Indoor Microbiomes is Mainly Ascribed to Variation in Type of Indoor Surface
Authors: Koide Roger T. , Kanauchi Makoto , Hashimoto Yasushi 
Published: January 2024

AbstractMiso is a microbially-fermented soybean food. The miso brewery indoor microbiome contributes to miso fermentation. Japanese breweries are not climate-controlled, so indoor spaces are strongly affected by the prevailing climate. Because climate influences microorganism distribution, our first hypothesis is that latitude, as a proxy for climate, is a major determinant of brewery indoor microbiome structure. Breweries vary in interior surface materials and in the way operations (steaming, processing, fermenting) are apportioned among rooms. Therefore, our second hypothesis is that more variability in indoor microbiomes exists among breweries than can be ascribed to a latitudinal gradient. Most miso produced today is inoculated with commercial microbial strains to standardize fermentation. If commercial strains outcompete indigenous microbes for membership in the indoor microbiome, this practice may homogenize indoor microbiomes among regions or breweries. Therefore, our third hypothesis is that inoculant fungal species dominate indoor fungal communities and make it impossible to distinguish communities among breweries or across their latitudinal gradient. We tested these hypotheses by sampling indoor surfaces in several breweries across a latitudinal gradient in Japan. We found that latitude had a significant but relatively small impact on indoor fungal and bacterial communities, that the effect of brewery was large relative to latitude, and that inoculant fungi made such small contributions to the indoor microbiome that distinctions among breweries and along the latitudinal gradient remained apparent. Recently, the Japanese Ministry of Agriculture, Forestry and Fisheries specified fungal inoculants to standardize miso production. However, this may not be possible so long as the indoor microbiome remains uncontrolled.