bluuebunny/crossref_metadata_2025_split huggingface dataset:
I am supporting RIO Journal. I think you should too
Authors: Mounce Ross 
Published: October 2023

Today (2015-09-01), marks the public announcement of Research Ideas &amp; Outcomes (RIO for short), a new open access journal for all disciplines that seeks to open-up the entire research cycle with some truly novel features I know what you might be thinking: *Another open access journal? Really? * Myself, nor Daniel Mietchen simply wouldn’t be involved with this project if it was just another boring open access journal.
ANÁLISE TEMPORAL DO USO DA TERRA NA BACIA DO RIO GRANDE NO ESTADO DE MINAS GERAIS
Authors: Gonçalves Lacerda de Gouveia Rogerio , Rodrigues Barbosa Gustavo 
Published: October 2023

O objetivo deste trabalho foi identificar e quantificar o uso da terra na Bacia Hidrográfica do rio Grande no Estado de Minas Gerais, com área total de 86345,43 km², nos anos 1990, 2000, 2010 e 2020. Foram utilizadas as imagens do satélite LANDSAT com resolução espacial de 30 m, em que o projeto Mapbiomas processa os dados e disponibiliza um produto com várias classes de uso da terra desde 1985 até o momento. O grau de antropização foi verificado por meio do Índice de Transformação Antrópica. Foram identificadas dez classes de uso da terra na bacia do rio Grande no Estado de Minas Gerais: mata nativa, formação campestre, silvicultura, campo alagado, massas d´água, pastagem, agricultura, outras áreas não vegetadas, mineração e área urbanizada. Os resultados indicaram a diminuição nos percentuais das classes: 12,07% na mata nativa, 0,49% em campo alagado e 0,07% em outras áreas não vegetadas. Por outro lado, a área de uso da terra aumentou 4,88% na agricultura, 3,31% pastagem, 1,95% massas d’água, 1,66% silvicultura, 0,66% área urbanizada, 0,15% formação campestre e 0,01% mineração. Portanto, este trabalho evidenciou alteração drástica da paisagem e, por meio do Índice de Transformação Antrópica, verificou-se aumento de 4,55 para 5,14 entre os anos 1990 e 2020, ou seja, a área de estudo, que se encontrava na classe regular, passou a ser degradada em decorrência, sobretudo, das atividades antrópicas associadas à expansão da agricultura e da pastagem.
Selective Organ‐Targeting Hafnium Oxide Nanoparticles with Multienzyme‐Mimetic Activities Attenuate Radiation‐Induced Tissue Damage
Authors: Liu Dingxin , Cao Fei , Xu Zhifeng , Zhao Chunhua , Liu Zekun , Pang Jiadong , Liu Ze‐Xian , Moghiseh Mahdieh , Butler Anthony , Liang Shaoxia , Fan Weijun , Yang Jiang 
Published: October 2023

AbstractRadioprotective agents hold clinical promises to counteract off‐target adverse effects of radiation and benefit radiotherapeutic outcomes, yet the inability to control drug transport in human organs poses a leading limitation. Based upon a validated rank‐based multigene signature model, radiosensitivity indices are evaluated of diverse normal organs as a genomic predictor of radiation susceptibility. Selective ORgan‐Targeting (SORT) hafnium oxide nanoparticles (HfO2 NPs) are rationally designed via modulated synthesis by α‐lactalbumin, homing to top vulnerable organs. HfO2 NPs like Hensify are commonly radioenhancers, but SORT HfO2 NPs exhibit surprising radioprotective effects dictated by unfolded ligands and Hf(0)/Hf(IV) redox couples. Still, the X‐ray attenuation patterns allow radiological confirmation in target organs by dual‐beam spectral computed tomography. SORT HfO2 NPs present potent antioxidant activities, catalytically scavenge reactive oxygen species, and mimic multienzyme catalytic activities. Consequently, SORT NPs rescue radiation‐induced DNA damage in mouse and rabbit models and provide survival benefits upon lethal exposures. In addition to inhibiting radiation‐induced mitochondrial apoptosis, SORT NPs impede DNA damage and inflammation by attenuating activated FoxO, Hippo, TNF, and MAPK interactive cascades. A universal methodology is proposed to reverse radioenhancers into radioprotectors. SORT radioprotective agents with image guidance are envisioned as compelling in personalized shielding from radiation deposition.
Data‐driven lifestyle patterns and risk of dementia in older Australian women
Authors: Dingle Sara E , Bowe Steven J , Bujtor Melissa , Milte Catherine M , Daly Robin M , Byles Julie , Cavenagh Dominic , Torres Susan J 
Published: October 2023

AbstractINTRODUCTIONMany lifestyle factors have been associated with dementia, but there is limited evidence of how these group together. The aim of this study was to examine the clustering of lifestyle behaviors and associations with dementia.METHODSThis population‐based study included 9947 older Australian women. Latent class analysis was employed to identify distinct lifestyle classes, and Cox proportional hazard regression compared these with incident dementia over 17 years.RESULTSThree classes were identified: (1) “highly social and non‐smokers” (54.9%), (2) “highly social, smokers, and drinkers” (25.1%), and (3) “inactive and low socializers” (20.0%). Women in Class 3 exhibited a higher risk of dementia compared to both Class 1 (hazard ratio [HR] = 1.19, 95% confidence interval [CI]: 1.08 to 1.30) and Class 2 (HR = 1.12, 95% CI: 1.00 to 1.25).DISCUSSIONA lifestyle pattern characterized by physical inactivity and low social engagement may be particularly detrimental for dementia risk in older women and should be prioritized in preventive strategies.Highlights
Latent class analysis was employed to identify distinct lifestyle clusters.
Three lifestyle‐related clusters were differentially associated with dementia risk.
Inactive and low socializers exhibited the greatest risk of dementia.
Targeting physical inactivity and low social engagement in prevention is vital.
Protective effect of Clinacanthus nutans in cisplatin‐induced nephrotoxicity on human kidney cell (PCS‐400‐010) elucidated by an LCMS‐based metabolomics approach
Authors: Mahmod Ilya Iryani , Ismail Intan Safinar , Normi Yahaya M. , Chong Siok‐Geok 
Published: October 2023

AbstractCisplatin‐induced nephrotoxicity has been widely reported in numerous studies. The objective of this study is to assess the potential nephroprotective effects of Clinacanthus nutans (Burm. f.) Lindau (Acanthaceae) leaf extracts on human kidney cells (PCS‐400‐010) in vitro using an LCMS‐based metabolomics approach. Orthogonal partial least square‐discriminant analysis identified 16 significantly altered metabolites when comparing the control and pre‐treated C. nutans cisplatin‐induced groups. These metabolites were found to be associated with glycerophospholipid, purine, and amino acid metabolism, as well as the glycolysis pathway. Pre‐treatment with C. nutans aqueous extract (125 μg/mL) for 24 h, followed by 48 h of cisplatin induction in PCS‐400‐010 cells, demonstrated a nephroprotective effect, particularly involving the regulation of amino acid metabolism.
Chief Executive Officer (CEO) and corporate environmental sustainability: A systematic literature review and avenues for future research
Authors: Mahran Karim , Elamer Ahmed A. 
Published: October 2023

AbstractEnvironmental sustainability has gained significant importance for organizations, highlighting the crucial role of business leaders in addressing environmental degradation. However, the connection between chief executive officer (CEO) characteristics and environmental sustainability remains understudied in academic literature. Understanding this relationship is crucial, considering the significance of environmental sustainability in organizational strategies. This paper presents the first systematic literature review (SLR) on this topic, aiming to identify gaps and opportunities for future research. The SLR analysed 139 studies on the CEO–environmental sustainability relationship. The findings indicate a recent increase in research activity, particularly peaking in 2022 and focusing on China and the United States. Most studies employed upper echelons theory and examined the influence of CEO demographic characteristics on environmental performance. However, less attention has been given to CEO psychological traits, such as personality and ethical leadership, and environmental disclosure. Furthermore, qualitative aspects of environmental disclosure, including reporting tone, readability and specificity, have received less attention. The findings offer valuable insights for academics, practitioners and policymakers. Recommendations for future research include exploring the impact of CEO psychological traits and environmental disclosure on a firm's environmental sustainability. Additionally, studying cross‐country and cross‐industry differences in this relationship is encouraged. This study makes a significant contribution to the field by shedding light on the crucial and relevant topic of environmental sustainability and its association with CEO characteristics, providing valuable insights to guide future research and inform decision‐makers.
Investigations into the human metabolism of ecdysterone
Authors: Piper Thomas , Thevis Mario 
Published: October 2023

AbstractThe possible performance‐enhancing effects and medical benefits of ecdysterone (ECDY) have been discussed several times throughout the last decades. In 2020, the World Anti‐Doping Agency include ECDY in their monitoring programme and continued this prevalence study until now. Only little is known about the human metabolism of ECDY besides the first study performed on human subjects in the field of sports drug testing that was already conducted in 2001. Aim of this study was the in‐depth investigation on human ECDY metabolism to improve its detectability and to support the decision‐making processes as to how ECDY can be implemented most effectively into sports drug testing regulations. In a first trial, one male volunteer was administered with threefold deuterated ECDY to enable the detection and potential identification of all urinary metabolites still comprising the deuterium label by employing hydrogen isotope ratio mass spectrometry and high‐resolution/high‐accuracy mass spectrometry. Samples were collected for up to 14 days, and metabolites excreted unconjugated, glucuronidated, and sulphated were investigated. The detected deuterated metabolites were confirmed in a second administration trial encompassing two male and one female volunteers. After the administration of 50 mg of unlabelled ECDY, urine samples were collected for up to 7 days. Besides the already described urinary metabolites of ECDY, more than 20 new metabolites were detected encompassing all expected metabolic conversions including side chain cleavage at C21. A large interindividual variation in the amounts of excreted metabolites was visible, and considerable differences in abundances of early‐ and late‐excretion phase metabolites were observed.
Ethics of Adaptive Designs for Randomized Controlled Trials
Authors: Chongwe Gershom , Ali Joseph , Kaye Dan Kabonge , Michelo Charles , Kass Nancy E. 
Published: October 2023

ABSTRACTOver recent decades, adaptive trial designs have been used more and more often for clinical trials, including randomized controlled trials (RCTs). This rise in the use of adaptive RCTs has been accompanied by debates about whether such trials offer ethical and methodological advantages over traditional, fixed RCTs. This study examined how experts on clinical trial methods and ethics believe that adaptive RCTs, compared to fixed ones, affect the ethical character of clinical research. We conducted in‐depth interviews with 17 researchers from bioethics, epidemiology, biostatistics, and/or medical backgrounds. While about half believed that adaptive trials are more complex and may thus threaten autonomy, these respondents also expressed that this challenge is not insurmountable. Most respondents expressed that efficiency and potential for participant benefit were the main justifications for adaptive trials. There was tension about whether adaptive randomization in response to increasing information disrupts clinical equipoise, with some respondents insisting that uncertainty still exists and therefore clinical equipoise is not disrupted. These findings suggest that further discussion is needed to increase the awareness and utility of these study designs.
Translational Research and Communities
Authors: Doerr Megan , Yu Joon‐Ho 
Published: October 2023

ABSTRACTImpactful translational research requires new approaches to computational analysis and bioethics, both of which have been advanced by adoption of community‐engagement strategies. Community knowledge and experience will hone data collection, research, and insights and accelerate the impact of derived translational applications to improve individual health, medical decision‐making, and public health policy. In the context of translational research with big health data, meaningful community‐researcher engagement will require developing and deploying coengagement tools across the research life cycle and developing approaches for novel coproduction.
Cross‐border acquisitions by sovereign wealth funds: A legitimacy‐based view
Authors: Murtinu Samuele , Scalera Vittoria G. , Strange Roger 
Published: October 2023

AbstractResearch SummaryDrawing on institutional economics and the legitimacy‐based view of political risk, we investigate the factors determining the realization of cross‐border investments by sovereign wealth funds (SWFs), whose investments often suffer from a lack of legitimacy in host countries. Using matching models on all the realized and potential investments, we find that investments are more likely to materialize when the SWF home country and the host country enjoy cordial political relations or are involved in a trade agreement. Contrary to the theoretical predictions, SWF politicization does not per se represent an impediment to the realization of investments. Rather, it has a negative effect on the likelihood of an investment's realization only in the presence of trade agreements.Managerial SummaryA recent trend in the global economy is the increasing cross‐border investment activity undertaken by sovereign wealth funds (SWFs), large investment vehicles where financial and political goals often co‐exist. On the grounds of possible financial or political destabilization, SWFs' cross‐border investments attract scrutiny and suspicion in host countries, hindering their realization. We analyze SWF‐ and country‐level factors that may determine the successful realization of SWFs' cross‐border acquisitions. We suggest that managers ex ante select target firms and host countries by considering their fund's governance and degree of independence from home‐country politics in interaction with bilateral (home‐host country) political and economic relations, so as to secure legitimacy for their investments and maximize the chances that cross‐border investment strategies may materialize.
Editors’ Statement on the Responsible Use of Generative AI Technologies in Scholarly Journal Publishing
Authors: Kaebnick Gregory E. , Magnus David Christopher , Kao Audiey , Hosseini Mohammad , Resnik David , Dubljević Veljko , Rentmeester Christy , Gordijn Bert , Cherry Mark J. 
Published: October 2023

AbstractGenerative artificial intelligence (AI) has the potential to transform many aspects of scholarly publishing. Authors, peer reviewers, and editors might use AI in a variety of ways, and those uses might augment their existing work or might instead be intended to replace it. We are editors of bioethics and humanities journals who have been contemplating the implications of this ongoing transformation. We believe that generative AI may pose a threat to the goals that animate our work but could also be valuable for achieving those goals. In the interests of fostering a wider conversation about how generative AI may be used, we have developed a preliminary set of recommendations for its use in scholarly publishing. We hope that the recommendations and rationales set out here will help the scholarly community navigate toward a deeper understanding of the strengths, limits, and challenges of AI for responsible scholarly work.
Characterization of Calcium‐ and Strontium‐Polyphosphate Particles Toward Drug Delivery into Articular Cartilage
Authors: Nhan Jordan , Strebel Nicolas , Virah Sawmy Khushnouma , Yin Jordan , St‐Pierre Jean‐Philippe 
Published: October 2023

AbstractDrug delivery into articular cartilage poses many challenges due in part to its lack of vasculature. While intra‐articular injections are effective for the local administration of drugs, small molecules are rapidly cleared from the synovial fluid. As such, there is a need to develop effective drug delivery strategies to improve the residence times of bioactive molecules in the joint and elicit a sustained therapeutic effect. In this study, calcium‐ and strontium‐polyphosphate particles are synthesized and characterized as potential drug carriers into articular cartilage. Physicochemical characterization reveals that the particles exhibit a spherical morphology, have a negative zeta potential, and are nanoscale in size. Biological characterization in chondrocytes confirms cellular uptake of the particles and demonstrates both size and concentration‐dependent cytotoxicity at high concentrations. Furthermore, treatment of chondrocytes with these particles results in a reduction in cell proliferation and metabolic activity, confirming biological effects. Finally, incubation with cartilage tissue explants suggests successful uptake, despite the particles exhibiting a negative surface charge. Therefore, from the results of this study, these polyphosphate‐based particles have potential as a drug carrier into articular cartilage and warrant further development.
Automated analysis of the total choline resonance peak in breast proton magnetic resonance spectroscopy
Authors: Javor Domagoj , Bennani‐Baiti Barbara I. , Clauser Paola , Kifjak Daria , Baltzer Pascal A. T. 
Published: October 2023

AbstractThe aim of the current study was to compare the performance of fully automated software with human expert interpretation of single‐voxel proton magnetic resonance spectroscopy (1H‐MRS) spectra in the assessment of breast lesions. Breast magnetic resonance imaging (MRI) (including contrast‐enhanced T1‐weighted, T2‐weighted, and diffusion‐weighted imaging) and 1H‐MRS images of 74 consecutive patients were acquired on a 3‐T positron emission tomography‐MRI scanner then automatically imported into and analyzed by SpecTec‐ULR 1.1 software (LifeTec Solutions GmbH). All ensuing 117 spectra were additionally independently analyzed and interpreted by two blinded radiologists. Histopathology of at least 24 months of imaging follow‐up served as the reference standard. Nonparametric Spearman's correlation coefficients for all measured parameters (signal‐to‐noise ratio [SNR] and integral of total choline [tCho]), Passing and Bablok regression, and receiver operating characteristic analysis, were calculated to assess test diagnostic performance, as well as to compare automated with manual reading. Based on 117 spectra of 74 patients, the area under the curve for tCho SNR and integrals ranged from 0.768 to 0.814 and from 0.721 to 0.784 to distinguish benign from malignant tissue, respectively. Neither method displayed significant differences between measurements (automated vs. human expert readers, p > 0.05), in line with the results from the univariate Spearman's rank correlation coefficients, as well as the Passing and Bablok regression analysis. It was concluded that this pilot study demonstrates that 1H‐MRS data from breast MRI can be automatically exported and interpreted by SpecTec‐ULR 1.1 software. The diagnostic performance of this software was not inferior to human expert readers.
Comparison between self‐reported and actigraphy‐derived sleep measures in patients receiving home parenteral nutrition: Secondary analysis of observational data
Authors: Rahmoune Adline , Winkler Marion F. , Saxena Richa , Compher Charlene , Dashti Hassan S. 
Published: October 2023

AbstractBackgroundPatients receiving home parenteral nutrition (HPN) frequently report disrupted sleep. However, there are often inconsistencies between objectively measured and questionnaire‐derived sleep measures. We compared sleep measures estimated from wrist actigraphy and self‐report in adults receiving HPN.MethodsIn this secondary analysis, we pooled data from two sleep‐related studies enrolling adults receiving habitual HPN. We compared measures from 7‐day averages of wrist actigraphy against comparable responses to a sleep questionnaire. Sleep measures included bedtime, wake time, time in bed, total sleep time, and sleep onset latency (SOL). Spearman correlation coefficients, Bland‐Altman plots, and linear regression models for each set of sleep measures provided estimates of agreement.ResultsParticipants (N = 35) had a mean age of 52 years, body mass index of 21.6 kg/m2, and 77% identified as female. Correlation coefficients ranged from 0.35 to 0.90, were highest for wake time (r = 0.90) and bedtime (r = 0.74), and lowest for total sleep time (r = 0.35). Actigraphy overestimated self‐reported bedtime, wake time, and total sleep time and underestimated self‐reported time in bed and SOL. Regression coefficients indicated the highest calibration for bedtime and wake time and lower calibration for time in bed, total sleep time, and SOL.ConclusionWe observed strong‐to‐moderate agreement between sleep measures derived from wrist actigraphy and self‐report in adults receiving HPN. Weaker correlations for total sleep time and SOL may indicate low wrist actigraphy sensitivity. Low‐quality sleep resulting from sleep disruptions may have also contributed to an underreporting of perceived sleep quantity and lower concordance.
Association of adversities and mental health among first‐ and second‐generation Arab American young adults
Authors: Albdour Maha , DiMambro Marissa R. , Solberg Marvin A. , Jenuwine Elizabeth S. , Kurzer Julie A. M. J. , Hong Jun Sung 
Published: October 2023

AbstractThe prevalence of mental health problems among young adults is widely recognized. However, limited research has examined the mental health of Arab American young adults specifically. To address this gap in the literature, this study aimed to investigate the effects of multiple stressors including adverse childhood experiences (ACEs), discrimination, and bullying victimization on the mental health of first‐ and second‐generation Arab American young adults. The participants (N = 162) were recruited from a Midwest university using online and in‐person methods. They were screened and completed a demographic questionnaire and self‐report measures of ACEs, discrimination, bullying victimization, and mental health. Hierarchical multiple regression analysis was conducted to examine the effect of psychosocial stressors on mental health and the moderating effect of generation (first vs. second) on that relationship. Female gender, increased perceived discrimination, and more ACEs were associated with lower mental health scores (β = −0.316, p < 0.001, β = −0.308, p < 0.001, and β = −0.230, p = 0.002, respectively). There was a significant negative relationship between victimization and mental health for first‐generation Arab Americans (β = −0.356, p = 0.010). However, that association all but disappeared for second‐generation participants (β = 0.006, p = 0.953). The results highlight the impact of multiple adversities on Arab American young adults' mental health and indicate important nuances related to their generation in the association between bullying victimization and mental health. Implications for practice and future research are discussed.