bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of visual diagnostic accuracy of dermatologists practicing in Germany in patients with light skin and skin of color
Authors: Krefting Frederik , Moelleken Maurice , Hölsken Stefanie , Placke Jan-Malte , Eisenburger Robin Tamara , Albrecht Lea Jessica , Tasdogan Alpaslan , Schadendorf Dirk , Ugurel Selma , Dissemond Joachim , Sondermann Wiebke 
Published: November 2023

Abstract
Visual clinical diagnosis of dermatoses in people of color (PoC) is a considerable challenge in daily clinical practice and a potential cause of misdiagnosis in this patient cohort. The study aimed to determine the difference in visual diagnostic skills of dermatologists practicing in Germany in patients with light skin (Ls) and patients with skin of color (SoC) to identify a potential need for further education. From April to June 2023, German dermatologists were invited to complete an online survey with 24 patient photographs depicting 12 skin diseases on both Ls and SoC. The study's primary outcomes were the number of correctly rated photographs and the participants’ self-assessed certainty about the suspected visual diagnosis in Ls compared to SoC. The final analysis included surveys from a total of 129 dermatologists (47.8% female, mean age: 39.5 years). Participants were significantly more likely to correctly identify skin diseases by visual diagnostics in patients with Ls than in patients with SoC (72.1% vs. 52.8%, p ≤ .001, OR = 2.28). Additionally, they expressed higher confidence in their diagnoses for Ls than for SoC (73.9 vs. 61.7, p ≤ .001). Therefore, further specialized training seems necessary to improve clinical care of dermatologic patients with SoC.
Cognitive profile, neuroimaging and fluid biomarkers in post-acute COVID-19 syndrome
Authors: Guillén Núria , Pérez-Millan Agnès , Falgàs Neus , Lledó-Ibáñez Gema M , Rami Lorena , Sarto Jordi , Botí Maria A , Arnaldos Cristina , Ruiz-García Raquel , Naranjo Laura , Segura Bárbara , Balasa Mircea , Sala-Llonch Roser , Lladó Albert , Gray Sarah , Johannesen Jason , Pantoni Madeline , Rutledge Grant , Sawant Ruta , Wang Yi , Watson Luke , Dalmau Josep , Sánchez-Valle Raquel 
Published: November 2023

Abstract
We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with cognitive complaints, exploring the influence of biological and psychological factors. Participants with confirmed SARS-CoV-2 infection and cognitive complaints ≥ eight weeks post-acute phase were included. A comprehensive neuropsychological battery (NPS) and health questionnaires were administered at inclusion and at 1, 3 and 6 months. Blood samples were collected at each visit, MRI scan at baseline and at 6 months, and, optionally, cerebrospinal fluid. Cognitive features were analyzed in relation to clinical, neuroimaging, and biochemical markers at inclusion and follow-up. Forty-nine participants, with a mean time from symptom onset of 10.4 months, showed attention-executive function (69%) and verbal memory (39%) impairment. Apathy (64%), moderate-severe anxiety (57%), and severe fatigue (35%) were prevalent. Visual memory (8%) correlated with total gray matter (GM) and subcortical GM volume. Neuronal damage and inflammation markers were within normal limits. Over time, cognitive test scores, depression, apathy, anxiety scores, MRI indexes, and fluid biomarkers remained stable, although fewer participants (50% vs. 75.5%; p = 0.012) exhibited abnormal cognitive evaluations at follow-up. Altered attention/executive and verbal memory, common in PACS, persisted in most subjects without association with structural abnormalities, elevated cytokines, or neuronal damage markers.
Prevalence and Associated Factors of Depression among Women with Advanced Pelvic Organ Prolapse in Northwest Ethiopia
Authors: Abebe Sileshi Ayele , Gashaw Zelalem Mengistu , Ayichew Zelalem , Abebaw Dessie , Kindie Endeshaw Asaye 
Published: November 2023

Abstract
Background
Depressive disorders are characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. There is no adequate evidence of the burden of depression among women with pelvic organ prolapse and its associated factors in Ethiopia. This study was performed to determine the prevalence of depression among women with advanced pelvic organ prolapse and to identify factors associated with depression in these women.
Methods
A facility-based cross-sectional study was conducted among 367 women who were diagnosed with advanced pelvic organ prolapse at Gondar University Comprehensive Specialized Hospital. The data were collected from January 01 to April 30, 2023. To select a total of 367 participants, a consecutive sampling technique was applied by female trained BSC-midwives. A structured questionnaire was used to obtain sociodemographic characteristics and clinical characteristics of the participants. Depression measures were obtained by using the Patient Health Questionnaire (PHQ) tool, which is validated in Ethiopia, using a cut point of five and above, which is considered to indicate depressive symptoms. Women who screened positive were linked to a psychiatric clinic for further evaluation and treatment. Data were entered into a computer using Epi Info version 3.5.3 and then exported to STATA version 14 for analysis. Multivariable logistic regressions were fitted, and odds ratios with 95% confidence intervals with a P value less than 0.05 were used to identify statistically significant factors.
Results
The prevalence of depression was found to be 47.1% (95% CI: 43%-52%). Being rural (AOR = 4.8; CI: 1.11–16.32), having a history of divorce because of pelvic organ prolapse (AOR = 5.5; CI: 1.85–16.32) and having a history of urinary symptoms (AOR = 3.1; CI: 1.12–8.59) were found to be independently associated with depressive symptoms.
Conclusions and recommendations:
The prevalence of depressive symptoms among women with advanced pelvic organ prolapse in this study is high. Being a rural resident, being divorced because of pelvic organ prolapse and having urinary symptoms are independently associated with depressive symptoms. Depression screening strategies should be designed for the early identification and treatment of depression among women with advanced pelvic organ prolapse.
Comprehensive Analysis of Hub Genes, Biological Mechanism and Predicted Drugs Related to Iron Metabolism in β-Thalassemia
Authors: Liu Rongrong , Chen Yongyu 
Published: November 2023

Abstract
Background: β-thalassemia is a common haemoglobinopathy. The pathogenesis is complex and has not been clearly elucidated, the present study provides possible references for the pathological mechanism of β-thalassemia related to iron metabolism, which sheds light on investigating potential biomarkers for the diagnosis of β-thalassemia.
Methods: β-thalassemia disease patients samples and healthy controls samples were collected. Using LIMMA package to find differentially expressed genes (DEGs). Afterward, DEGs have been subjected to enrichment analysis of GO and KEGG pathways. The PPI networks and Hub genes were then created and visualized. Comprehensive analysis of expression, construction of mRNA-miRNA-transcription factor (TF) network and drugs prediction of these top 10 hub-genes were further carried out.
Results: The micro array data of 12 samples of the GSE62431 showed 816 significant DEGs. Enrichment analysis showed terms related to iron metabolism. There exists a higher proportion of immune infiltration in healthy samples than β-thalassemia patients. 10 hub genes associated with both iron metabolism and β-thalassemia were identified. Finally, we have preliminarily achieved the identification, expression, construction of mRNA-miRNA-TF network and drugs Prediction of Hub-Genes
Conclusion: There is a strong close relationship between β-thalassemia and iron metabolism. Iron-related genes have the potential to be a prognostic biomarker for β-thalassemia.
Analytical solutions and asymptotic profiles of vacuum free boundary for the compressible Euler equations with time-dependent damping
Authors: Li Kunquan , Jia Jia , Zhang Meng , Guo Zhengguang 
Published: November 2023

Abstract
We constructed a class of analytical, rotationaland self-similar solutions to the isentropic compressible Euler equations with time-dependent damping $\frac{\mu}{\left( 1+t\right) ^{\lambda}}%\rho\mathbf{u}$ ($\mu\geq0$, $\lambda\in\mathbb{R}$) and vacuum free boundary in cylindrical coordinates. These solutions capture the precise physical vacuum behavior that the sound speed is $C^{1/2}$-H\"older continuous across the boundary and are determined by the freeboundary $a(t)$, which is the solution of a second order nonlinear ordinarydifferential equation with parameters $\mu$ and $\lambda$ (see (1.12)) $). Furthermore, global well-posedness and asymptotic behavior of the free boundary $a(t)$ are presented in this paper. Precisely, we show that for $\lambda>1$ the freeboundary will grow linearly in time, and radial velocity $u^{r}$ and axial velocity $u^{z}$ are bounded, while the angular velocity $u^{\phi}$ and the radial derivatives of velocity components all tend to zero as $t\rightarrow+\infty$ (see Remark 1.4). However, if $\lambda\leq1$, the free boundary will grow sub-linearly in time. In particular, if $-1\leq \lambda\leq 1/(2\gamma-1)$, where $\gamma$ is the adiabatic exponent of polytropicgases, the free boundary will grow more slowly as $\lambda$ becomes smaller, and possesses a finite upper bound when $\lambda<-1$.
Mathematics Subject Classifications (2020): 35R35, 76N10
Identification of miRNAs biomarkers for prostate cancer in serum and tissue based on bioinformatic analysis and experimental validation
Authors: Lu Huimin , Sun Yuanjing , Chen Libo , Li Mingyong , Deng Weiming 
Published: November 2023

Abstract
Purpose
The aim of our research is to identify the key miRNAs and construct miRNA-mRNA networks for Prostate cancer (PCa).
Methods
Microarray dataset GSE112264 consisting of 1591 male serum samples and tissue miRNA data from TCGA including 497 prostate cancer and 52 normal sample were included for analysis. Differentially expressed miRNAs (DE-miRNAs) were detected by R package and miRTarBase was used to predict the common target genes. Then GO and KEGG pathway analysis was performed for the target genes. Protein–protein interaction (PPI) network which revealed top 10 hub genes was constructed by STRING database and Cytoscape software. The potential hub genes expression examined by UALCAN database. Finally, GSE112264, TCGA datasets and clinical samples were used for verifying the consistency of miRNAs expression in serum and tissue.
Results
A total of 948 target genes of the overlapped two downregulated miRNAs (miR-146a-3p and miR-136-3p) were predicted. Functional enrichment analysis indicated that significant DE-miRNAs were related to PCa-related pathway such as protein binding, mTOR signaling pathway and porphyrin and chlorophyll metabolism. 4 hub genes were identified from PPI network including NSF, HIST2H2BE, IGF2R and CADM1 and verified to be aberrantly expressed in UALCAN database. Experiment results indicated that only miR-136-3p was markedly reduced both in serum and tissue.
Conclusion
In this study, we established miRNA-mRNA network and provided new insight into the diagnostic biomarkers for PCa.
Comparison of properties of various modifications of liquid platelet rich fibrin protocols including Sticky bone, PRF block and albumin PRF
Authors: Hegde Namratha , B Tarun Kumar A , Shah Rucha , Thomas Raison , G.V Gayathri 
Published: November 2023

Abstract
BACKGROUND AND OBJECTIVES:
Platelet concentrates have been prevalently utilized in regenerative periodontal treatment as they are autologous in nature. PRF block, sticky bone, Alb-PRF, Alb-PRF block are composite materials using PRF and Bone graft, which activate the graft biologically as well as enhance the mechanical properties of the graft. Hence, the present study aims to compare the volumetric change, compressive strength and difference in SEM characteristics of L-PRF, A- PRF, i-PRF, of sticky bone (injectable PRF/i-PRF with a bone graft) and with PRF block (Advanced Platelet Rich Fibrin /A-PRF+ and i-PRF with bone graft), Alb-PRF, Alb-PRF block.
METHODOLOGY:
Blood specimens were collected from volunteers who were in good overall health and aged between 20 and 50 years. The samples were then subjected for preparation of L-PRF, A- PRF, i-PRF, sticky bone (injectable PRF/i-PRF with a bone graft) and with PRF block (Advanced Platelet Rich Fibrin /A-PRF+ and i-PRF with bone graft), Alb-PRF, Alb-PRF block which were further subjected to assessment of compressive strength, elastic modulus, final volume, degradation time and scanning electron microscopy in triplicates .
RESULTS:
On comparing, the mean compressive strength of Sticky bone was found to be (304.72±3.05Mpa), that for PRF Block was (256.69±2.12Mpa), Albumin PRF 84.9±3.05MPa and for Albumin PRF block was 187.5±3.75 Mpa The mean modulus of elasticity was found to be 32.66±1.52Mpa in the PRF Block, 27.41±1.03Mpa for Sticky bone, Albumin PRF 16.23±1.52MPa and for Albumin PRF block 16.23±1.52MPa. In the volumetric test, it was found that there was statistically significant increase in the mean volume of L-PRF, A-PRF , i-PRF was 1cm2, PRF Block 1.6cm3, sticky bone 1.2cm3, Alb-PRF 1.2cm3 , and Alb-PRF block was 1.4 cm3
CONCLUSION:
The findings of this current research suggest that sticky bone, PRF block, Albumin PRF, and Alb-PRF block all have the potential to substantially improve the degradation time, strength and volume of the graft material.
Assessment of thoracic tumors by FAPI PETCT: a systematic evaluation and meta-analysis
Authors: Wang Ting , Huang Delong , Liao Shuang , Wang Yiren , Deng Hairui , Zhong Haoshu , Wu Junhao , Yang Qiuya , Yang Lu , Pang Haowen , Ju Mei , Zhou Ping 
Published: November 2023

Abstract
Objective: Standard imaging techniques may not be suitable for evaluating thoracic tumor metastases, despite the high prevalence of thoracic cancers worldwide. Recent developments in PET/CT techniques using fibrogenic activating protein inhibitors (FAPI) show promise in assessing thoracic tumor metastasis. We reviewed the latest data on FAPI PET/CT for analyzing original malignancies, lymph node metastases, and remote metastases in thoracic cancers. Additionally, a meta-analysis was conducted to determine the sensitivity of FAPI PET/CT in diagnosing thoracic malignancies, including primary and non-primary foci (lymph node metastases and remote metastases)
Methods: We searched the Cochrane Library, Embase, and PubMed databases from their establishment until June 23, 2023. Our screening and review included all studies that used FAPI PET/CT to examine thoracic malignancies. Three investigators conducted the filtration and full-text analysis, while two investigators collected the data. We used the QUADAS-2 tool to assess the risk of bias. A diagnostic test study was performed using a random-effects model.
Results: Our systematic review and meta-analysis comprised 13 studies out of the 796 total publications we identified. These 13 articles included data from 475 patients with thoracic tumors, 475 primary thoracic tumor lesions, and 3296 metastatic thoracic tumor lesions. In order to identify primary thoracic cancers , patient-based FAPI PET/CT had a sensitivity of 0.98 (95% CI: 0.90-1.00). For the diagnosis of original thoracic tumor lesions and the diagnosis of metastatic thoracic tumor lesions, the sensitivity of lesion-based FAPI PET/CT was 0.98 (95% CI: 0.91-1.00) and 0.99 (95% CI: 0.95-1.00), respectively.
Conclusion: FAPI PET/CT demonstrates superior sensitivity and specificity in diagnosing thoracic cancers. Radiologists, nuclear medicine experts, and clinicians could think about employing FAPI PET/CT to assess primary and non-primary foci (lymph node metastases and remote metastases)in thoracic cancers.
Dataset of an actual motor vehicle insurance portfolio
Authors: Segura-Gisbert Jorge , Lledó Josep , Pavía Jose M. 
Published: November 2023

Abstract
Advanced analytics plays a vital role in enhancing various aspects of business operations within the insurance sector, providing valuable insights that drive informed decision-making, primarily through effective database utilization. However, open access databases in the insurance industry are exceedingly rare, as they are the basis of the business, encapsulating all the risk structure of the company. This makes it challenging for researchers and practitioners to access comprehensive insurance datasets for analysis. This paper introduces an extensive database specifically tailored for non-life motor insurance, containing 105,555 rows and encompassing a wide array of 30 variables. The dataset comprises important date-related information, such as effective date, date of birth of the insured, and renewal date, essential for policy management and risk assessment. Additionally, it includes relevant economic variables, such as premiums and claim costs, for assessments of products’ financial profitability. Moreover, the database features an array of risk-related variables, such as vehicle size, economic value, power, and weight, which significantly contribute to understanding risk dynamics. By leveraging the statistical analysis of this rich database, researchers could identify novel risk profiles, reveal variables that influence insured claims behaviour, and contribute to the advancement of educational and research initiatives in the dynamic fields of economics and actuarial sciences. The availability of this comprehensive database opens new opportunities for research and teaching and empowers insurance professionals to enhance their risk assessment and decision-making processes.
Lipopolysaccharide promotes the recovery of dextran sulfate sodium- induced colitis by regulating the Toll-like receptor 4 signaling pathway
Authors: Wu Zixin , Liu Mengao , Chen Wenbin , He Zijian , Li Guanwei , Rao Benqiang , Cao Jie , Li Wanglin 
Published: November 2023

Abstract
Background: The roles of lipopolysaccharide (LPS) and Toll-like receptor 4 (TLR4) in the recovery of colitis were further investigated.
Methods: Human normal colonic epithelial cells with low, normal and high expression levels of TLR4 were constructed using lentiviral transfection, and subsequently incubated with LPS. Cells were divided into low + LPS, normal + LPS and high + LPS groups. The expression levels of cytokines were examined using quantitative real-time PCR and ELISA. Cell migration was observed using wound healing assays. In vivo, mice with dextran sulfate sodium (DSS)-induced colitis were treated with LPS and a TLR4 inhibitor, TAK-242. Changes in body weight, colonic length and the histopathology of mice were analyzed.
Results: The expression levels of TLR4 in the high + LPS group were significantly increased in a time-dependent manner. Compared with the normal + LPS group, the expression levels of TNF-α, IL-6, IL-8 and IL-1β in the high + LPS group were significantly decreased, while the expression levels of IL-10 were reversed. The migratory ability of cells with high TLR4 expression was markedly increased. In vivo, compared with the TAK-242 group, mice with DSS-induced colitis in the LPS group exhibited a positive weight increase, longer colon length and reduced inflammatory infiltration, and the expression levels of TNF-α and IL-6 were significantly reduced, and the expression levels of IL-10 were significantly increased.
Conclusion: LPS promoted the release of cytokines and auxiliary stimulating molecules to regulate the inflammatory response and promote the recovery of colitis by regulating the TLR4 pathway.
Efficacy of the ExVent Accessory for the O2Vent Optima Oral Appliance in the Treatment of Obstructive Sleep Apnea
Authors: Sharma Sat , Conflitti Antonella , Reiter Hilary , Rajkumar Winston , Simeunovic Banko , Shukla Yaj , Coscarella Gennaro 
Published: November 2023

Abstract
Study Objectives
An optional accessory for the O2Vent Optima mandibular advancement device, the ExVent, provides oral expiratory positive airway pressure (EPAP). Similar to nasal EPAP, oral EPAP results in passive airway dilatation, reducing flow limitation. The present study was conducted to evaluate the safety and efficacy of the ExVent accessory for the treatment of mild to moderate obstructive sleep apnea (OSA).
Methods
This prospective, multicenter, open-label, single-arm study enrolled participants diagnosed with mild to moderate OSA (defined as apnea–hypopnea index [AHI] 5–29). During the Home Use Phase, study participants logged their hours of O2Vent Optima + ExVent usage at home over 3 months. Participants were then evaluated by in-laboratory polysomnogram while using the O2Vent Optima + ExVent. The primary effectiveness measure was a change in AHI relative to baseline while using the O2Vent Optima + ExVent.
Results
Treatment with the O2Vent Optima + ExVent improved AHI by 62% on average, from 15.3 (interquartile range [IQR]: 11.5–19.5) to 5.8 (IQR: 3.9–6.8; p<0.001). Mean oxygen saturation improved from 93.5%±1.2% to 94.6%±1.34% (p=0.006). The lowest oxygen saturation increased from 85% (IQR: 83%–87%) to 90% (IQR: 89%–95; p<0.001). The overall treatment success rate (AHI<5) was 66%, and the treatment response rate (>50% reduction in AHI) was 77%. No excessive adverse events or device malfunction events were reported.
Conclusions
Use of the O2Vent Optima with the ExVent oral EPAP accessory successfully reduced AHI in mild to moderate OSA with no significant adverse effects.
Schulkulturbezogene Schultypen im Zeitalter der digitalen Transformation
Authors: Caruso Carina , Drossel Kerstin , Heldt Melanie 
Published: November 2023

Angesichts des technischen Fortschritts, eines Digitalisierungsdefizits an deutschen Schulen sowie der Erfahrungen in Schule und Unterricht als Folge der Corona-Pandemie wird sichtbar, dass die Frage nach einer lernförderlichen Schulkultur im Zeitalter der digitalen Transformation ihre Relevanz behält: Einerseits zeigt sich, dass sich die Schulkultur im Zeitalter der digitalen Transformation verändert, weil Potenziale und Herausforderungen für Schule und Unterricht mit dieser verbunden sind. Andererseits trägt sie zur erfolgreichen Implementation digitaler Medien bei. Bisherige Forschungsbefunde im Zusammenhang mit der digitalen Transformation fokussieren insbesondere die Input- bzw. Akteurs- und Handlungsebene, u. a. digitalisierungsbezogene Kompetenzen von Lehrkräften (Meyer, Becker, und Bock 2023; Caruso, Heldt, und Drossel 2022; Vogelsang et al. 2023) und deren Kooperationsverhalten (Drossel und Heldt 2022; Schulze, Drossel, und Eickelmann 2022). Weniger beleuchtet ist bisher jedoch, wie Lehrkräfte angesichts der digitalen Transformation die Schulkultur an ihrer Schule wahrnehmen und inwiefern sich auf dieser Basis schulkulturbezogene Schultypen identifizieren lassen. Diesen Fragen widmet sich dieser Beitrag und exploriert, inwiefern sich die schulkulturbezogenen Schultypen in Bezug auf die Hintergrundmerkmale der befragten Lehrkräfte unterscheiden. Auf Grundlage einer Latent Class Analysis werden drei schulkulturbezogene Schultypen ersichtlich: innovations- und kooperationsstark (Typ I: 45,74 %), innovationsstark und kooperationsgehemmt (Typ II: 17,95 %), innovations- und kooperationsgehemmt (Typ III: 36,31 %). Die Typen unterscheiden sich hinsichtlich der Hintergrundmerkmale nicht voneinander.