bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Toxicokinetic–Toxicodynamic Modeling Workflow Assessing the Quality of Input Mortality Data
Authors: Bauer Barbara , Singer Alexander , Gao Zhenglei , Jakoby Oliver , Witt Johannes , Preuss Thomas , Gergs André 
Published: October 2023

Abstract
Toxicokinetic–toxicodynamic (TKTD) models simulate organismal uptake and elimination of a substance (TK) and its effects on the organism (TD). The Reduced General Unified Threshold model of Survival (GUTS-RED) is a TKTD modeling framework that is well established for aquatic risk assessment to simulate effects on survival. The TKTD models are applied in three steps: parameterization based on experimental data (calibration), comparing predictions with independent data (validation), and prediction of endpoints under environmental scenarios. Despite a clear understanding of the sensitivity of GUTS-RED predictions to the model parameters, the influence of the input data on the quality of GUTS-RED calibration and validation has not been systematically explored. We analyzed the performance of GUTS-RED calibration and validation based on a unique, comprehensive data set, covering different types of substances, exposure patterns, and aquatic animal species taxa that are regularly used for risk assessment of plant protection products. We developed a software code to automatically calibrate and validate GUTS-RED against survival measurements from 59 toxicity tests and to calculate selected model evaluation metrics. To assess whether specific survival data sets were better suited for calibration or validation, we applied a design in which all possible combinations of studies for the same species–substance combination are used for calibration and validation. We found that uncertainty of calibrated parameters was lower when the full range of effects (i.e., from high survival to high mortality) was covered by input data. Increasing the number of toxicity studies used for calibration further decreased parameter uncertainty. Including data from both acute and chronic studies as well as studies under pulsed and constant exposure in model calibrations improved model predictions on different types of validation data. Using our results, we derived a workflow, including recommendations for the sequence of modeling steps from the selection of input data to a final judgment on the suitability of GUTS-RED for the data set. Environ Toxicol Chem 2024;43:197–210. © 2023 Bayer AG and The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Interactive Effects of Copper–Silver Mixtures at the Intestinal Epithelium of Rainbow Trout: An In Vitro Approach
Authors: Ibrahim Md , Belden Jason B. , Minghetti Matteo 
Published: October 2023

Abstract
While metals are present in mixture in the environment, metal toxicity studies are usually conducted on an individual metal basis. There is a paucity of data in the existing literature regarding specific metal−metal interactions and their effect on metal toxicity and bioavailability. We studied interactions of a silver (Ag)–copper (Cu) mixture at the intestinal epithelium using an intestinal cell line derived from rainbow trout (Oncorhynchus mykiss), the RTgutGC. Exposures were conducted in media containing different chloride concentrations (low chloride, 1 mM; high chloride, 146 mM), thus resulting in different metal speciation. Cytotoxicity was evaluated based on two endpoints, cell metabolic activity and cell membrane integrity. The Ag–Cu mixture toxicity was assessed using two designs: independent action and concentration addition. Metal mixture bioavailability was studied by exposing cells to 500 nM of Ag or Cu as a single metal or a mixture (i.e., 500 nM of Cu plus 500 nM of Ag). We found an antagonistic effect in the low-chloride medium and an additive/synergistic effect in the high-chloride medium. We found that Cu dominates over Ag toxicity and bioavailability, indicating a competitive inhibition when both metals are present as free metal ions in the exposure media, which supports our hypothesis. Our study also suggests different mechanisms of uptake of free metal ions and metal complexes. The study adds valuable information to our understanding of the role of metal speciation on metal mixture toxicity and bioavailability. Environ Toxicol Chem 2024;43:105–114. © 2023 SETAC.
FIGO good practice recommendations for induced or spontaneous labor at term: Prep‐for‐Labor triage to minimize risks and maximize favorable outcomes
Authors: Borovac‐Pinheiro Anderson , Inversetti Annalisa , Di Simone Nicoletta , Barnea Eytan R. ,   the FIGO Childbirth and Postpartum Hemorrhage Committee
Published: October 2023

AbstractThe goal of induced or spontaneous labor is childbirth by vaginal delivery. Delivery after 37 weeks is desirable and associated with favorable maternal and newborn outcomes. Delivery facilities should have suitable staff and resources on site for antenatal services and delivery care. FIGO's Prep‐for‐Labor triage method provides rapid diagnostic tools that help define patients as high or low risk to determine whether transfer to a higher‐level center is needed. There is often a disconnect between a facility's designation and its ability to achieve safe deliveries. For preplanned labor induction, the designated clinical facility must have the right set‐up and prenatal records available to achieve a successful outcome. However, this is often not the case if a patient arrives in labor or needs an induction and the facility has limited patient information and resources, thus requiring rapid management decisions. The practical guidance checklist in this article defines maternal and/or fetal risk factors and delineates approaches and safe practices for labor induction and management, including when antenatal information is limited to maximize safe delivery practices. Guidelines on using the Bishop score (>6 or <6) to manage labor are presented. Evidence supporting successful safe labor induction at 41–42 weeks of gestation in low‐risk cases is described. This practice will increase the rate of spontaneous labor and delivery, minimizing intervention and thereby diverting limited clinical resources to those patients in need. In the right setting, this could lead to around 80% of women delivering spontaneously, which remains a desired goal.
FIGOgood practice recommendations: Bundle of care to reduce neonatal mortality and improve outcomes after preterm and term delivery
Authors: Costa Simonetta , Menzella Nicoletta , Vento Giovanni , Barnea Eytan R. ,   the FIGO Childbirth and Postpartum Hemorrhage Committee
Published: October 2023

AbstractAn integrated approach is lacking for the management of childbirth and newborn care, even though their codependence is critical for improving maternal and newborn outcomes. FIGO's Prep‐for‐Labor rapid triage methods for women arriving at a clinical facility are addressed in earlier papers in this Supplement, but do not include newborn care. Immediate postpartum rapid triage using established Apgar score helps determine whether standard of care can be followed on site with available staff/tools. If not, newborn transfer alone or with the mother to a higher‐level center as soon as feasible may be required. Updated newborn management tools with special emphasis on pragmatic steps that are applicable for any clinical setting including low‐ and middle‐income countries (LMICs) are presented in this article. Given that more than 80% of newborn care can be managed at the birthing facility, transfer to a higher‐level center for care is required only in selected cases. Management steps for healthy newborns are described and the actions needed for those requiring resuscitation are summarized. The simple noninvasive kangaroo mother care approach—universally applicable for both term and preterm newborns—is associated with a significant reduction in morbidity and mortality. Kangaroo mother care involves continuous maternal skin‐to skin contact from birth, exclusive breastfeeding, and home support after discharge. Hence, hypothermia, hypoglycemia, and acquired infections are frequently prevented. It is anticipated that implementing simple noninvasive management steps will have a substantial positive impact on improving maternal and newborn outcomes.
Evaluating the use of preparation guides in interteaching versus a quiz alternative
Authors: Schena David , Rosales Rocío , Soldner James L. 
Published: October 2023

AbstractInterteaching is a behavioral teaching method that has demonstrated efficacy in higher education. Of particular interest is the use of a preparation guide (a guided reading assignment), which is designed to promote engagement in the other areas of the interteaching process. The present study compared the use of a preparation guide completed before the start of class with that of a quiz administered at the start of the class. The quiz was hypothesized to serve as a functional alternative to the preparation guide. A total of 38 undergraduate students enrolled in an Introduction to Psychology course participated in this study. The primary dependent measure was student performance on tests following each condition. The analysis revealed no statistically significant difference between the conditions, F(1, 302) = 0.103, p = .748, though qualitative feedback revealed student preference for preparation guides. Future research is necessary to examine the effects of quizzing while addressing the limitations of this study.
Carbonic anhydrase inhibition by antiviral drugs in vitro and in silico
Authors: Türkeş Cüneyt 
Published: October 2023

AbstractEnzyme inhibition is a commonly utilized method for controlling enzymatic activity in various physiologically relevant biological systems. Herein, the selected five active antiviral drugs, abacavir, emtricitabine, lamivudine, ribavirin, and ritonavir, were assayed as inhibitors of two human isoforms of the metalloenzyme carbonic anhydrase (hCA, EC 4.2.1.1) involved in various physiological/pathological conditions. For this aim, in vitro and in silico studies were performed to gain insights into the plausible binding interactions and affinities for the antiviral drugs within hCA I and II isoforms' active sites. The hCA I, an isoform involved in some pathological conditions such as retinal or cerebral edema, was moderately inhibited by these five drugs at micromolar concentrations with KIs spanning from 0.49 ± 0.05 to 3.51 ± 0.37 μM compared with the reference drug acetazolamide (AAZ, KI of 0.19 ± 0.01 μM). Moreover, hCA II, a promising target for edema, glaucoma, epilepsy, and altitude sickness, was a reasonably inhibited isoform by these agents, with KIs in the range of 0.64 ± 0.08–5.80 ± 0.64 μM compared with AAZ (KI of 0.17 ± 0.01 μM). Both in vitro and in silico results demonstrated significant interactions between these five drugs and hCAs and that they can support therapeutic targets against the above‐mentioned pathological conditions. Additionally, the results obtained will help optimize the clinical dosage regimens of these drugs and avoid drug–drug interactions unexpectedly when used in combination with other agents.
An Ultraviolet‐Transparent Ultrasound Transducer Enables High‐Resolution Label‐Free Photoacoustic Histopathology
Authors: Kim Donggyu , Park Eunwoo , Park Jeongwoo , Perleberg Bjarne , Jeon Sora , Ahn Joongho , Ha Mingyu , Kim Hyung Ham , Kim Jin Young , Jung Chan Kwon , Kim Chulhong 
Published: October 2023

AbstractUltraviolet photoacoustic microscopy (UV‐PAM), based on the high intrinsic optical absorption of DNA/RNA, holds great promise for intraoperative label‐free histopathological imaging modalities. Although clinical histopathology requires high‐resolution images to observe individual cell structures, conventional UV‐PAM suffers from relatively low resolution compared to the clinical histological modalities. Notably, opto‐ultrasound beam combiners or ring‐shaped ultrasound transducers, which have been used as geometrically coaxial methods of conventional reflection‐mode UV‐PAMs, restrict the numerical apertures (NA) due to their long working distances and/or hollow structures. Here, an ultraviolet‐transparent ultrasound transducer (UV‐TUT) is demonstrated that enables high‐resolution reflection‐mode UV‐PAM by improving the NA (0.38) and consequent spatial resolution (0.47 ± 0.03 µm). The study has successfully demonstrated its superior performance with mouse brain tissue and performed photoacoustic histopathology with cancerous animal tissues. This work proposes the ultimate form of a label‐free reflection‐mode UV‐PAM system with the potential to boost the practical use of intraoperative photoacoustic histopathology.
Remarks on Chemin's space of homogeneous distributions
Authors: Cobb Dimitri 
Published: October 2023

AbstractThis paper focuses on Chemin's space of homogeneous distributions, which was introduced to serve as a basis for the realizations of subcritical homogeneous Besov spaces. We will discuss how this construction fails in multiple ways for supercritical spaces. In particular, we study its intersection with various Banach spaces , namely supercritical homogeneous Besov spaces and the Lebesgue space . For each , we investigate whether the intersection is dense in . If it is not, then we study its closure and prove that the quotient is not separable and that is not complemented in .
Collapsed oyster populations in large Florida estuaries appear resistant to restoration using traditional cultching methods—Insights from ongoing efforts in multiple systems
Authors: Pine W. E. , Brucker J. , Davis M. , Geiger S. , Gandy R. , Shantz A. , Stewart Merrill T. , Camp E. V. 
Published: October 2023

Abstract

Objective
Depressed eastern oyster Crassostrea virginica populations in the northern Gulf of Mexico have been the target of numerous post-Deepwater Horizon restoration projects. These projects primarily have focused on replacing oyster cultch (substrate) to promote spat settlement, increase recruitment, and bolster adult oyster populations. This study assessed the outcomes of six such efforts, which used different cultch types and densities between 2015 and 2022 in three estuaries on the Florida panhandle (Pensacola, St. Andrew, and Apalachicola bays). Total restoration costs for these projects were more than US$14 million.

Methods
Using generalized linear models, we analyzed oyster count data collected from diver surveys in three size-classes (spat, seed, and adult). We tested whether oyster population responses in the six restoration efforts varied over time, location, or study design.

Result
Oyster counts did not persistently increase after restoration, regardless of cultch type or density. Positive responses to restoration efforts were irregular and short-lived and seemed only to occur for spat-size oysters immediately after restoration. None of the restoration efforts significantly improved the abundance of oysters of any size-class in any of the study estuaries. Factors contributing to these results likely include design and implementation elements, such as the materials used and the height of the restored reefs. However, monitoring programs have not been able to deliver a clear picture of what is hindering restoration success.

Conclusion
For oyster restoration efforts to succeed, changes are needed—both in their implementation and in the way they are monitored—in order to promote continuous learning and improvement in restoration outcomes.
Will carbon emission trading policy improve the synergistic reduction efficiency of pollution and carbon? Evidence from 216 Chinese cities
Authors: Bai Tingting , Qi Yong , Li Zihao , Xu Dong 
Published: October 2023

AbstractBased on the panel data of 216 Chinese cities from 2008 to 2018, the synergistic reduction efficiency of pollution and carbon (SREPC) was calculated using the super‐efficiency slack‐based measure model. Differences‐in‐differences (DID), propensity score matching (PSM)–DID, and spatial‐DID were adopted to study the impact of the carbon emission trading (CET) policy on SREPC. The study results show that SREPC was not improved overall, with an unbalanced development characteristic of high efficiency in the east and low efficiency in the west. The Meta‐frontier results show that there were indeed significant differences between pilot and non‐pilot cities before and after the implementation of the CET policy. Mechanism tests reveal that CET promoted SREPC by improving energy efficiency and optimizing industrial structures. Spatial analysis shows that CET had spatial spillover effects and decreased SREPC in neighboring cities. These reduction effects occurred in neighboring non‐pilot cities and showed an inverted U‐shaped relationship with increasing geographical distance, particularly significant within 500–600 km. Inverse data envelopment analysis shows that CET can utilize the synergistic reduction potential of pollution and carbon.
Systematic Review and Quantitative Data Synthesis of Peripheral Blood Mononuclear Cell Transcriptomics Reveals Consensus Gene Expression Changes in Response to a High Fat Meal
Authors: Dordevic Aimee L. , Williamson Gary 
Published: October 2023

ScopeMetabolic flexibility is essential for a healthy response to a high fat meal, and is assessed by measuring postprandial changes in blood markers including peripheral blood mononuclear cells (PBMCs; lymphocytes and monocytes). However, there is no clear consensus on postprandial gene expression and protein changes in these cells.Method and resultsThe study systematically reviews the literature reporting transcriptional and proteomic changes in PBMCs after consumption of a high fat meal. After re‐analysis of the raw data to ensure equivalence between studies, ≈85 genes are significantly changed (defined as in the same direction in ≥3 studies) with about half involved in four processes: inflammation/oxidative stress, GTP metabolism, apoptosis, and lipid localization/transport. For meals consisting predominantly of unsaturated fatty acids (UFA), notable additional processes are phosphorylation and glucocorticoid response. For saturated fatty acids (SFA), genes related to migration/angiogenesis and platelet aggregation are also changed.ConclusionDespite differences in study design, common gene changes are identified in PBMCs following a high fat meal. These common genes and processes will facilitate definition of the postprandial transcriptome as part of the overall postcibalome, linking all molecules and processes that change in the blood after a meal.
An inexpensive method for reliable recovery of stream temperature data
Authors: Rogers Kevin B. , Hodge Brian W. 
Published: October 2023

Abstract

Objective
Water temperature is perhaps the single-most important environmental driver of fish populations. The strong relationship between fish and water temperature allows fisheries managers to make predictions about the influence of temperature on fishes under both current and future climatic conditions. These predictions are more robust if based on year-round and long-term data. However, water temperature data are commonly compromised or lost altogether when data-logging temperature sensors are damaged or go missing. In recognition of the need for reliable ways to collect long-term, year-round temperature data, we designed, implemented, and tested a durable but cryptic logger deployment and retrieval system.

Methods
We used metal housings and stakes to protect and anchor temperature loggers on the streambed and, when necessary, used a metal detector to assist with logger recovery. We then evaluated logger recovery rates across 12 years and 312 deployments at 85 sites in first- to ninth-order Rocky Mountain streams and rivers.

Result
Although we recovered only 73% of loggers with traditional means of retrieval (e.g., GPS or photo), presumably owing to the inconspicuous nature of our metal housings and streambed anchor stakes, we recovered 96% of loggers when a metal detector was also used. Ordinal and binary logistic regression revealed that a metal detector was especially beneficial when trying to recover loggers from unfamiliar monitoring sites or those deployed for long periods of time (years).

Conclusion
Our methods could be replicated for a reliable and inexpensive approach to acquiring year-round stream temperature data.
Proportion of caloric restriction‐induced weight loss as skeletal muscle
Authors: Heymsfield Steven B. , Yang Shengping , McCarthy Cassidy , Brown Jasmin B. , Martin Corby K. , Redman Leanne M. , Ravussin Eric , Shen Wei , Müller Manfred J. , Bosy‐Westphal Anja 
Published: October 2023

AbstractObjectiveThis study's objective was to develop models predicting the relative reduction in skeletal muscle (SM) mass during periods of voluntary calorie restriction (CR) and to validate model predictions in longitudinally monitored samples.MethodsThe model development group included healthy nonexercising adults (n = 897) who had whole‐body SM mass measured with magnetic resonance imaging. Model predictions of relative SM changes with CR were evaluated in two longitudinal studies, one 12 to 14 weeks in duration (n = 74) and the other 12 months in duration (n = 26).ResultsA series of SM prediction models were developed in a sample of 415 males and 482 females. Model‐predicted changes in SM mass relative to changes in body weight (i.e., ΔSM/Δbody weight) with a representative model were (mean ± SE) 0.26 ± 0.013 in males and 0.14 ± 0.007 in females (sex difference, p < 0.001). The actual mean proportions of weight loss as SM in the longitudinal studies were 0.23 ± 0.02/0.20 ± 0.06 in males and 0.10 ± 0.02/0.17 ± 0.03 in females, similar to model‐predicted values.ConclusionsNonelderly males and females with overweight and obesity experience respective reductions in SM mass with voluntary CR in the absence of a structured exercise program of about 2 to 2.5 kg and 1 to 1.5 kg per 10‐kg weight loss, respectively. These estimates are predicted to be influenced by interactions between age and body mass index in males, a hypothesis that needs future testing.
Trans‐oceanic subsurface photovoltaic performance
Authors: Krawczyk Collin A. , Shafer Michael W. , Flikkema Paul G. , Rose Holser Rachel , Costa Daniel 
Published: October 2023

AbstractUtilization of marine photovoltaic energy is primarily focused on surface harvesting with limited photovoltaic cell implementations in submarine environments. Potential applications include marine wildlife telemetry devices, autonomous underwater vehicles, or remote sensing assets. In these applications, understanding the power at depth is critical, but there has yet to be a long‐term study of cell performance in a realistic marine environment that spans time, geographic location, and depth. In this paper, we present photovoltaic assessments carried out by devices mounted to adult female northern elephant seals (Mirounga angustirostris) during their spring migrations in the Pacific Ocean with deployment times between 76 and 107 days. Encompassing a large geographic area between Santa Cruz, California, and the Aleutian Islands of Alaska during their migrations, elephant seal behavior allows for repeated depth profiles each day, making them an ideal host for subsurface power assessments. This paper presents the first longitudinal study of photovoltaic cell performance in the marine environment that spans location, time, and depth. This work discusses the calibration, data time alignment, and power calculations of these oceanic deployments. Deployment results, including power results and energy predictions from the data record, are presented up to 22 m in depth. We highlight how the recorded power data of these cells compares to previously published results and how depth impacts subsurface power and energy harvesting.