bluuebunny/crossref_metadata_2025_split huggingface dataset:
Situações de bullying no contexto universitário: percepções de estudantes de um curso de fonoaudiologia
Authors: Alpes Matheus Francoy , Santos Julia Helena Ferreira dos , Panúncio-Pinto Maria Paula 
Published: November 2023

Introdução: O bullying corresponde a situações de agressões verbais e físicas que ocorrem de maneira intencional e repetitiva contra um indivíduo em desvantagem de poder, causando inúmeros problemas e sequelas durante toda a vida. Pode se manifestar em diferentes ambientes, dentre eles, no contexto universitário. Objetivo: Identificar a percepção de graduandos do curso de Fonoaudiologia sobre o bullying. Método: Estudo descritivo-exploratório, no qual participantes foram abordados através de questionário semi-estruturado. Os dados foram analisados quali-quantitativamente, através de análise de conteúdo (questões abertas) e frequência simples (questões fechadas). Resultados: Dentre os 94 respondentes, 59 (62,7%) identificaram situações de bullying na graduação: na relação veterano-calouro (20); motivada por características pessoais (20); por orientação sexual/gênero (13); na relação professor-aluno (09); motivada por desempenho acadêmico (08); classe social (07) e etnia (05). Em relação ao desempenho acadêmico, 91 (96,8%) consideraram que a vítima têm prejuízo em seu desempenho acadêmico: provoca sofrimento psíquico e desgaste emocional (36), desmotivação e desinteresse pela faculdade (25), isolamento social e repressão da expressão (13); afeta o bem-estar geral (10) e desempenho no cotidiano (04). Conclusão: Os estudantes reconhecem a ocorrência do fenômeno no contexto da graduação e concordam que tais situações afetam o processo de ensino-aprendizagem.
The Common Core of the Fundamental Standards of International Humanitarian Law and International Human Rights Law
Authors: Orzeszyna Krzysztof 
Published: November 2023

Abstract
The presented paper discusses the convergence of international humanitarian law and international human rights law in armed conflicts. International human rights law and the human rights law converge and interact with each other because natural law is at the core of both these disciplines of public international law. Although international humanitarian law is a lex specialis, the general rules regarding the interpretation of treaties clearly indicate that international human rights law must be interpreted in the context of other rules of international law, and its possible derogations must be compatible with other international obligations of the state, including humanitarian law. In the event of a conflict between international humanitarian law and international human rights law, the mechanism for resolving conflicts between the standards was supplemented by an interpretation based on the principle of ‘system integration’ of the International Court of Justice which results in the ‘humanization’ of international humanitarian law. The evolution of the case-law of the European Court of Human Rights, which takes into account the international humanitarian law as the reference norm that should be referred to, demonstrates the close relationship between these areas of law. In the case of the application of universal and regional instruments of international human rights law, we are dealing with the ‘humanitarianization’ of these rights.
Fermented rape pollen powder can alleviate benign prostatic hyperplasia in rats by reducing hormone content and changing gut microbiota
Authors: Han Y.Y. , Zhang Q.H. , Chen W.S. , Li Z.L. , Xie D. , Zhang S.L. , Lu H. , Wang L.W. , Xu Z.H. , Zhang L.Z. 
Published: November 2023

Abstract
Benign prostatic hyperplasia (BPH) can cause urethral compression, bladder stone formation, and renal function damage, which may endanger the life of patients. Therefore, we aimed to develop plant-based preparations for BPH treatment with no side effects. In this study, the Lactiplantibacillus plantarum 322Hp, Lactobacillus acidophilus 322Ha, and Limosilactobacillus reuteri 322Hr were used to ferment rape pollen. The fermented rape pollen was subsequently converted into fermented rape pollen powder (FRPP) through vacuum freeze-drying technology. After fermenting and drying, the bioactive substances and antioxidant capacity of FRPP were significantly higher than those of unfermented rapeseed pollen, and FRPP had a longer storage duration, which can be stored for over one year. To investigate the therapeutic effect of FRPP on BPH, a BPH rat model was established by hypodermic injection of testosterone propionate. The BPH rats were treated differently, with the model group receiving normal saline, the positive control group receiving finasteride, and the low, medium, and high dose FRPP group receiving FRPP at doses of 0.14 g/kg/d, 0.28 g/kg/d, and 0.56 g/kg/d, respectively. The results indicate that medium dose FRPP reduced the levels of hormone such as testosterone, dihydrotestosterone, and oestradiol in rats with BPH by about 32%, thus bringing the prostate tissue of BPH rats closer to normal. More importantly, medium dose FRPP treatment had a significant effect on the composition of gut microbiota in rats with BPH, increasing the levels of beneficial genera (such as Coprococcus and Jeotgalicoccus), and decreasing the levels of harmful pathogens (such as Turicibacter and Clostridiaceae_Clostridium) in the gut. This study showed that medium dose FRPP reduced the hormone level and regulated the unbalanced gut microbiota in BPH rats, thereby alleviating BPH.
Pearl S. Buck, Her Nobel Prize, and the Nazis
Authors: Hudey Katrin 
Published: November 2023

Abstract
In 1938, Pearl S. Buck was decorated with the highest literature award possible: the Nobel Prize. In most cases an award like this leads to a high increase in the symbolic capital for the author and raises the value of their books, but not for Pearl S. Buck. Looking closer at the global reception of Pearl S. Buck’s books before and after the awarding reveals that giving the Nobel Prize to her was for several reasons one of the most discussed decisions by the Swedish Committee. In the following, I will look exemplarily at the constellation of USA, China, and Nazi-Germany to reconstruct how her books were received in different national contexts before and after 1938 to investigate the global and national effects of her awarding.
The Nobel Literature Prize and Peacebuilding
Authors: Cheuk Michael Ka-chi 
Published: November 2023

Abstract
Organized as part of the Cultural Olympiad for the 1996 Atlanta Olympic Games, “The Nobel Laureates of Literature: An Olympic Gathering” featured the largest ever assembly of Nobel laureates in literature for a single occasion. It was expected that the eight writers in attendance, namely Joseph Brodsky, Czesław Miłosz, Toni Morrison, Kenzaburō Ōe, Octavio Paz, Claude Simon, Wole Soyinka, and Derek Walcott, would singularly promote the values of peacebuilding. Instead, the laureates demonstrated varying degrees of uneasiness. By close-reading the panel discussion transcript in conjunction with the writers’ Nobel lectures, this paper argues for an alternative reading of the Olympic Gathering as a platform where the artistic visions of the eight writers interacted with each other on topics related to mutual understanding, privacy, and communication. Rather than reinforcing the liturgy of global peacebuilding, the Nobel laureates transformed the Olympic Gathering into a critical space that simultaneously promotes and deconstructs its peacebuilding processes.
Foreword to a Special Issue on “Interreligious Founding”
Authors: Chitwood Zachary , Lohse Tillmann , Sánchez Ignacio , Schmiedchen Annette 
Published: November 2023

Abstract
This short introduction prefaces an ends special issue devoted to the topic of “interreligious founding”, whose contributions stem from an online workshop held April 8th–9th, 2021. This workshop was planned as a continuation of the dialogue on charitable foundations held between experts of various academic disciplines in Tokyo (2019) and Singapore (2020). As a result of discussions begun at these venues, it has become apparent that the scholarship on endowments, which has unfolded to the greatest extent within Medieval Studies and therefore with the context of the medieval Latin West foremost in mind, has not adequately addressed the phenomenon of interreligious patronage, that is the participation in foundation activities by persons of different religious traditions.
Feeling Happiness, Feeling Science: Diffractive Readings of Émilie Du Châtelet’s and Sophie Germain’s Philosophical Writings
Authors: Tamboukou Maria 
Published: November 2023

Abstract
In this paper I read diffractively the philosophical writings of Émilie Du Châtelet and Sophie Germain, particularly focusing on their engagement with happiness, both as a theoretical notion and as a lived experience. What I argue is that their take on happiness has nothing to do with the gendered norms and discourses of happiness that they were seen and judged by, in the longue durée of the nineteenth and twentieth centuries. Their happiness was more in line with the joys and pleasures of knowledge, understanding, living, and creating. While feelings are central in both women’s theorization of happiness, they are deployed along different strands in the philosophical history of emotions and affects, and despite their original and unique contribution, they are still absent from it.
The Siberian Storm Track Weakens the Warm Arctic–Cold Eurasia Pattern
Authors: Yang Minghao , Li Yi , Dong Wei , Shi Weilai , Yu Peilong , Chen Xiong 
Published: November 2023

Abstract
With a particular focus on the Siberian storm track, this study provides new insights into variations in the warm Arctic–cold Eurasia (WACE) temperature anomaly pattern by using reanalysis data. The results show that the Siberian storm track has a significant out-of-phase relationship with both the WACE pattern and Ural blocking on the interannual time scale. The strengthened WACE pattern can weaken the Siberian storm track through a suppression of the low-level atmospheric baroclinicity over midlatitude Eurasia. The weakened Siberian storm track can contribute to the WACE pattern through feedback forcing from synoptic-scale eddies, which can also create favorable conditions for the development of Ural blocking. Composite temporal evolution reveals that the strongest cold Arctic–warm Eurasia pattern is preceded by the peak of the Siberian storm track. The Ural cyclonic circulation reaches its maximum amplitude on the peak day of the Siberian storm track strength and continues to persist for one day with the maximum amplitude due to the feedback forcing resulting from the Siberian storm track. On the intraseasonal time scale, the occurrence of the Siberian storm track activity can serve as an early indication of the diminished Ural blocking and WACE pattern.

Significance Statement
Because of the high impacts of the warm Arctic–cold Eurasia (WACE) pattern on public safety, socioeconomic development, and the economy, it is crucial to enhance our understanding of variations in the WACE pattern. This paper specifically investigates the impact of internal atmospheric variability on the WACE pattern, focusing on a pronounced negative correlation between the Siberian storm track and the WACE pattern. Daily composites also reveal that Siberian storm track activities can promote a strong cold Arctic–warm Eurasia pattern by maintaining the strength of the quasi-stationary Ural cyclonic circulation. As such, paying close attention to Siberian storm track activities may hold the promise to improve the prediction of the strength of the WACE pattern.
ABL1 kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma
Authors: Kumar Subodh , Talluri Srikanth , Zhao Jiangning , Liao Chengcheng , Potluri Lakshmi B. , Buon Leutz , Mu Shidai , Shi Jialan , Chakraborty Chandraditya , Tai Yu-Tzu , Samur Mehmet K. , Munshi Nikhil C. , Shammas Masood A. 
Published: November 2023

Abstract
Genomic instability contributes to cancer progression and is at least partly due to dysregulated homologous recombination (HR). Here, we show that an elevated level of ABL1 kinase overactivates the HR pathway and causes genomic instability in multiple myeloma (MM) cells. Inhibiting ABL1 with either short hairpin RNA or a pharmacological inhibitor (nilotinib) inhibits HR activity, reduces genomic instability, and slows MM cell growth. Moreover, inhibiting ABL1 reduces the HR activity and genomic instability caused by melphalan, a chemotherapeutic agent used in MM treatment, and increases melphalan’s efficacy and cytotoxicity in vivo in a subcutaneous tumor model. In these tumors, nilotinib inhibits endogenous as well as melphalan-induced HR activity. These data demonstrate that inhibiting ABL1 using the clinically approved drug nilotinib reduces MM cell growth, reduces genomic instability in live cell fraction, increases the cytotoxicity of melphalan (and similar chemotherapeutic agents), and can potentially prevent or delay progression in patients with MM.
Improved production of lactiplantibacillus plantarum RO30 exopolysaccharide (REPS) by optimization of process parameters through statistical experimental designs
Authors: Elmansy Eman Ahmed , Elkady Ebtsam M. , Asker Mohsen S. , Abdallah Nagwa A. , Khalil Bigad E. , Amer Shaimaa k. 
Published: November 2023

Abstract
Background
In investigating of (exopolysaccharide) EPS from unconventional sources, lactic acid bacteria have a vital role due to their generally recognized as safe (GRAS) status. EPSs have diverse applications such as drug delivery, antimicrobial activity, surgical implants, and many more in many sectors. Despite being important, the main hindrance to the commercial application of these significant biopolymers is low productivity. Therefore, this study primarily focuses on optimizing physio-chemical conditions to maximize the previously produced EPS from probiotic Lactiplantibacillus plantarum RO30 (L. plantarum RO30) using one factor at a time (OFAT) and method Response Surface Methodology (RSM).

Results
The EPS obtained from L. plantarum RO30 named REPS. The medium formulation for REPS production using the OFAT method revealed that sucrose (20 g/L, beef extract (25 g/L), and ammonium sulfate at 4 g/L concentration were the optimum carbon, organic and inorganic nitrogen sources, and REPS yield was increased up to 9.11 ± 0.51 g/L. RSM experiments revealed that, a greatly significant quadratic polynomial attained from the Central Composite Design (CCD) model was fruitful for specifying the most favorable cultural conditions that have significant consequences on REPS yield. The maximal amount of REPS (10.32 g/L) was formed by: sucrose (40 g/L), beef extract (25 g/L), pH (5.5), incubation temperature (30 °C), and incubation period (72 h). A high closeness was obtained between the predicted and experimental values and it displayed the efficiency of the RSM.

Conclusion
This study was conducted to reinforce REPS production in the probiotic LAB L. plantarum RO30 by utilizing various experimental parameters. The maximum REPS yield of 10.32 g/L was attained under the circumstances optimized in the study.
DNA methylation and lipid metabolism are involved in GA-induced maize aleurone layers PCD as revealed by transcriptome analysis
Authors: Wu Yequn , Hou Jiaqi , Ren Ruifei , Chen Zhenfei , Yue Mengxia , Li Le , Hou Haoli , Zheng Xueke , Li Lijia 
Published: November 2023

Abstract
Background
The aleurone layer is a part of many plant seeds, and during seed germination, aleurone cells undergo PCD, which is promoted by GA from the embryo. However, the numerous components of the GA signaling pathway that mediate PCD of the aleurone layers remain to be identified. Few genes and transcriptomes have been studied thus far in aleurone layers to improve our understanding of how PCD occurs and how the regulatory mechanism functions during PCD. Our previous studies have shown that histone deacetylases (HDACs) are required in GA-induced PCD of aleurone layer. To further explore the molecular mechanisms by which epigenetic modifications regulate aleurone PCD, we performed a global comparative transcriptome analysis of embryoless aleurones treated with GA or histone acetylase (HAT) inhibitors.

Results
In this study, a total of 7,919 differentially expressed genes (DEGs) were analyzed, 2,554 DEGs of which were found to be common under two treatments. These identified DEGs were involved in various biological processes, including DNA methylation, lipid metabolism and ROS signaling. Further investigations revealed that inhibition of DNA methyltransferases prevented aleurone PCD, suggesting that active DNA methylation plays a role in regulating aleurone PCD. GA or HAT inhibitor induced lipoxygenase gene expression, leading to lipid degradation, but this process was not affected by DNA methylation. However, DNA methylation inhibitor could regulate ROS-related gene expression and inhibit GA-induced production of hydrogen peroxide (H2O2).

Conclusion
Overall, linking of lipoxygenase, DNA methylation, and H2O2 may indicate that GA-induced higher HDAC activity in aleurones causes breakdown of lipids via regulating lipoxygenase gene expression, and increased DNA methylation positively mediates H2O2 production; thus, DNA methylation and lipid metabolism pathways may represent an important and complex signaling network in maize aleurone PCD.
H2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana
Authors: Frost Jennifer M. , Lee Jaehoon , Hsieh Ping-Hung , Lin Samuel J. H. , Min Yunsook , Bauer Matthew , Runkel Anne M. , Cho Hyung-Taeg , Hsieh Tzung-Fu , Fischer Robert L. , Choi Yeonhee 
Published: November 2023

Abstract
Background
H2A.X is an H2A variant histone in eukaryotes, unique for its ability to respond to DNA damage, initiating the DNA repair pathway. H2A.X replacement within the histone octamer is mediated by the FAcilitates Chromatin Transactions (FACT) complex, a key chromatin remodeler. FACT is required for DEMETER (DME)-mediated DNA demethylation at certain loci in Arabidopsis thaliana female gametophytes during reproduction. Here, we sought to investigate whether H2A.X is involved in DME- and FACT-mediated DNA demethylation during reproduction.

Results
H2A.X is encoded by two genes in Arabidopsis genome, HTA3 and HTA5. We generated h2a.x double mutants, which displayed a normal growth profile, whereby flowering time, seed development, and root tip organization, S-phase progression and proliferation were all normal. However, h2a.x mutants were more sensitive to genotoxic stress, consistent with previous reports. H2A.X fused to Green Fluorescent Protein (GFP) under the H2A.X promoter was highly expressed especially in newly developing Arabidopsis tissues, including in male and female gametophytes, where DME is also expressed. We examined DNA methylation in h2a.x developing seeds and seedlings using whole genome bisulfite sequencing, and found that CG DNA methylation is decreased genome-wide in h2a.x mutant endosperm. Hypomethylation was most striking in transposon bodies, and occurred on both parental alleles in the developing endosperm, but not the embryo or seedling. h2a.x-mediated hypomethylated sites overlapped DME targets, but also included other loci, predominately located in heterochromatic transposons and intergenic DNA.

Conclusions
Our genome-wide methylation analyses suggest that H2A.X could function in preventing access of the DME demethylase to non-canonical sites. Overall, our data suggest that H2A.X is required to maintain DNA methylation homeostasis in the unique chromatin environment of the Arabidopsis endosperm.
Cost consequence analysis of transcutaneous tibial nerve stimulation (TTNS) for urinary incontinence in care home residents alongside a randomised controlled trial
Authors: Fenocchi Linda , Mason Helen , Macaulay Lisa , O’Dolan Catriona , Treweek Shaun , Booth Joanne 
Published: November 2023

Abstract
Background
Urinary incontinence (UI) is prevalent in more than half of residents of nursing and residential care homes and can have a detrimental impact on dignity and quality of life. Care homes predominantly use absorbent pads to contain UI rather than actively treat the condition. Transcutaneous tibial nerve stimulation (TTNS) is a non-invasive, safe, low-cost intervention with demonstrated effectiveness for reducing UI in adults. We examined the costs and consequences of delivering TTNS to care home residents in comparison to sham (inactive) electrical stimulation.

Methods
A cost consequence analysis approach was used to assemble and present the resource use and outcome data for the ELECTRIC trial which randomised 406 residents with UI from 37 care homes in the United Kingdom to receive 12 sessions of 30 min of either TTNS or sham (inactive) TTNS. TTNS was administered by care home staff over 6 weeks. Health state utility was measured using DEMQOL-U and DEMQOL-PROXY-U at baseline, 6 weeks and 18 weeks follow-up. Staff completed a resource use questionnaire at baseline, 6 weeks and 18 weeks follow-up, which also assessed use of absorbent pads.

Results
HRQoL did not change significantly in either randomised group. Delivery of TTNS was estimated to cost £81.20 per participant, plus training and support costs of £121.03 per staff member. 85% of participants needed toilet assistance as routine, on average requiring one or two staff members to be involved 4 or 5 times in each 24 h. Daily use of mobility aids and other assistive devices to use the toilet were reported. The value of staff time to assist residents to use the toilet (assuming an average of 5 min per resident per visit) was estimated as £19.17 (SD 13.22) for TTNS and £17.30 (SD 13.33) for sham (per resident in a 24-hour period).

Conclusions
Use of TTNS to treat UI in care home residents did not lead to changes in resource use, particularly any reduction in the use of absorbent pads and no cost benefits for TTNS were shown. Managing continence in care homes is labour intensive, requiring both high levels of staff time and use of equipment aids.

Trial registration
ISRCTN98415244, registered 25/04/2018. NCT03248362 (Clinical trial.gov number), registered 14/08//2017.