bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proton versus photon therapy for high-risk prostate cancer with dose escalation of dominant intraprostatic lesions: a preliminary planning study
Authors: Ong Ashley Li Kuan , Knight Kellie , Panettieri Vanessa , Dimmock Mathew , Tuan Jeffrey Kit Loong , Tan Hong Qi , Wright Caroline 
Published: November 2023

Background and purposeThis study aimed to investigate the feasibility of safe-dose escalation to dominant intraprostatic lesions (DILs) and assess the clinical impact using dose-volume (DV) and biological metrics in photon and proton therapy. Biological parameters defined as late grade ≥ 2 gastrointestinal (GI) and genitourinary (GU) derived from planned (DP) and accumulated dose (DA) were utilized.Materials and methodsIn total, 10 patients with high-risk prostate cancer with multiparametric MRI-defined DILs were investigated. Each patient had two plans with a focal boost to the DILs using intensity-modulated proton therapy (IMPT) and volumetric-modulated arc therapy (VMAT). Plans were optimized to obtain DIL coverage while respecting the mandatory organ-at-risk constraints. For the planning evaluation, DV metrics, tumor control probability (TCP) for the DILs and whole prostate excluding the DILs (prostate-DILs), and normal tissue complication probability (NTCP) for the rectum and bladder were calculated. Wilcoxon signed-rank test was used for analyzing TCP and NTCP data.ResultsIMPT achieved a higher Dmean for the DILs compared to VMAT (IMPT: 68.1 GyRBE vs. VMAT: 66.6 Gy, p &lt; 0.05). Intermediate–high rectal and bladder doses were lower for IMPT (p &lt; 0.05), while the high-dose region (V60 Gy) remained comparable. IMPT-TCP for prostate-DIL were higher compared to VMAT (IMPT: 86%; α/β = 3, 94.3%; α/β = 1.5 vs. VMAT: 84.7%; α/β = 3, 93.9%; α/β = 1.5, p &lt; 0.05). Likewise, IMPT obtained a moderately higher DIL TCP (IMPT: 97%; α/β = 3, 99.3%; α/β = 1.5 vs. VMAT: 95.9%; α/β = 3, 98.9%; α/β = 1.5, p &lt; 0.05). Rectal DA-NTCP displayed the highest GI toxicity risk at 5.6%, and IMPT has a lower GI toxicity risk compared to VMAT-predicted Quantec-NTCP (p &lt; 0.05). Bladder DP-NTCP projected a higher GU toxicity than DA-NTCP, with VMAT having the highest risk (p &lt; 0.05).ConclusionDose escalation using IMPT is able to achieve a high TCP for the DILs, with the lowest rectal and bladder DV doses at the intermediate–high-dose range. The reduction in physical dose was translated into a lower NTCP (p &lt; 0.05) for the bladder, although rectal toxicity remained equivalent.
Influence of socio-affective factors on quality of life in women diagnosed with fibromyalgia
Authors: Ortega-Martínez Ana Raquel , Grande-Gascón María Luisa , Calero-García María José 
Published: November 2023

IntroductionFibromyalgia is a disease that involves chronic pain, with high prevalence in the female population and great impact on the bio-psycho-social sphere of people affected by it. However, few studies have analyzed the possible influence of socio-affective factors on the quality of life of people who suffer from this disease.ObjectiveThe aim of this study was to determine the relationships between the impact of this disease on the lives of people with fibromyalgia and these variables. Specifically, we analyzed the quality of partner relationship, perceived loneliness, life satisfaction, and perceived socio-family situation.MethodA descriptive-correlational cross-sectional design was used. The sample consisted of 69 women diagnosed with fibromyalgia. The participants completed different questionnaires that measured their happiness, satisfaction with life, perceived loneliness, quality of partner relationship, socio-family valuation, and the impact of fibromyalgia.ResultsThe quality of partner relationship, perceived loneliness and socio-family valuation seem to be good predictors of subjective happiness, life satisfaction, and the impact that fibromyalgia has on people’s lives, in the sense that the more positive the valuation of the couple relationship and of the socio-family situation, and the lower the perceived loneliness, people feel happier, more satisfied with their lives and the lower the impact that fibromyalgia has on their lives.ConclusionThe 50% of satisfaction with life can be explained from the scores obtained in perceived loneliness and the quality of partner relationship. In this sense, perceived loneliness was a good predictor of the impact of fibromyalgia on the lives of these patients.
From legends to legacy: the impact of fan influence on retiring athletes in premier league basketball
Authors: Lev Assaf , Levental Orr , Tamir Ilan 
Published: November 2023

IntroductionThis research examines the perceived age of Premier League basketball players as they near retirement, focusing on the complex interplay between players, fans, and the media in shaping perceptions of age and retirement. The study highlights the unique pressure on the basketball players to retire due to age-related expectations, rooted in the perception that athleticism is age dependent.MethodsThe research methodology applied in this study involved conducting semi-structured interviews with a sample of 11 professional Israeli basketball players and two veteran players’ agents.ResultsThree themes emerged: (1) Feelings of betrayal and ingratitude; (2) A farewell tour toward disengagement from one’s professional career; and (3) The media’s role in shaping beliefs and attitudes. These themes illustrate how the sports environment portrays aging players, shaping fan opinions, both positively and negatively. Significantly, the findings emphasize the challenges that players must confront within an ageist environment.DiscussionThe study concludes by highlighting the cultural and social construction at work. The “coercion” to retire from professional sports is more pronounced here due to the common belief that sports success is time-bound and age-dependent, necessitating a “young body”. In this reality, the audience does not merely function as a backdrop for athletes’ performances, but has the power, at the collective and the individual level, to affect change on and off the court.
Social cognition and emotional rehabilitation in participants with schizofrenia
Authors: Rodríguez Pulido Francisco , Caballero Estebaranz Nayra , García Caballero Alejandro Alberto , González Dávila Enrique , León Palacín Celia , Hernández Álvarez de Sotomayor María del Carmen , López Reig Susana , Vílchez de León Patricia Inés 
Published: November 2023

IntroductionPeople with schizophrenia have deficits in social cognition, emotion and social perception, as well as attributional style. The purpose of this study was to evaluate the efficacy of a multicomponent social cognition training program, e-Motional Training® (ET), in people with schizophrenia and to compare its efficacy with people who did not receive it. Therefore, a single-blind RCT was conducted in participants with a diagnosis of schizophrenia.MethodsA randomized, single-blind, clinical trial was conducted with 50 stable outparticipants with schizophrenia (registry number CHUC_2019_109). All participants (control and intervention) were treated with pharmacotherapy, case management and were on Individual Placement and Support methodology for competitive employment. The intervention group was treated with ET, an online program designed for social cognition rehabilitation. Pre and post assessment was performed using different battery of tests. General mixed models with subject identification and repeated measures over time were used.ResultsDifferent pre and post measurements were performed in the two groups. No significant differences were found in sociodemographic characteristics between the control and intervention groups. Improvements were obtained in the intervention group in the Ekman test (p = 0.009), mainly enhanced by the improvement shown in three emotions: fear, sadness and disgust (p = 0.041, p = 0.021 and p = 0.038 respectively).ConclusionET is a promising online training tool for social cognition deficits in schizophrenia, in particular, for the improvement of emotions.Clinical Trial Registration: https://beta.clinicaltrials.gov, NCT05866328.
Prevalence and related factors of abdominal obesity among urban adults aged 35 to 79 years in southwest China
Authors: Huang Chuan , Zhang Ying , Liu Ya , Liu Jian-Xiong , Hu Yong-Mei , Tang Wei-Wei , Wang Tzung-Dau , Huang Xiao-bo 
Published: November 2023

ObjectivesThis study aimed to investigate the prevalence and related factors of abdominal obesity among urban adults aged 35 to 79 years in southwest China.MethodsFrom September 2013 to March 2014, a multi-stage sampling was conducted, and a total of 10,981 people aged 35–79 years living in Chengdu and Chongqing were included. More than 30 investigators were trained in data collection, including questionnaire, anthropometric measurements and blood biomarkers testing. Abdominal obesity was defined as waist circumference ≥ 90 cm for men and ≥ 85 cm for women.ResultsThe prevalence of abdominal obesity was 30.7%, 24.8% in males and 33.9% in females (p &lt; 0.001). The prevalence of abdominal obesity increased with BMI. The prevalence of abdominal obesity was positively correlated with age, sex, marriage, alcohol consumption, hypertension and diabetes, and negatively correlated with high education level, smoking and Physical activity.ConclusionThe prevalence of abdominal obesity among adults aged 35–79 in urban communities in southwest China is high, which is close to that of adults in urban communities in China. We should strengthen health education among the population, adopt healthy diet, maintain moderate physical activity and other measures to curb the prevalence of abdominal obesity in urban communities in southwest China.
Factor structure and psychometric properties of an Arabic version of the Internet Gaming Disorder Scale, short form (IGDS-SF9)
Authors: El Keshky Mogeda El Sayed , Alballa Tmader 
Published: November 2023

BackgroundIn its most recent edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), the American Psychological Association recognized that internet gaming disorder is a psychological condition and provides nine criteria for its diagnosis, and the Internet Gaming Disorder Scale, short form (IGDS-SF9) was developed to assess individuals.AimTo develop and investigate the psychometric properties of an Arabic version of IGDS-SF9.MethodA five-stage translation and verification process produced an Arabic version of IGDS-SF9, and a study was conducted using a sample of 410 respondents (45.6% females, mean age = 17.6, SD = 1.56) to assess its psychometric properties. Respondents completed the Arabic version, the Smartphone Addiction Scale, the Smartphone Application-Based Addiction Scale, the Hospital Anxiety and Depression Scale, as well as a demographic survey. Exploratory and confirmatory factor analyses, measurement invariance, item response theory, convergent, concurrent, criterion validity, and internal consistency reliability and test–retest reliability were employed to validate the scale.ResultsThe exploratory factor analysis suggested the scale’s unidimensional structure; the confirmatory factor analysis exhibited good model fit and factor loadings. Measurement invariance, and concurrent, convergent, and criterion validity were established, resulting in good internal consistency and test–retest reliability for the scale.ConclusionThe Arabic version of IGDS-SF9 is a valid and reliable measure for research and diagnosis in Arabic-speaking countries.
Low-cost 3D printed inertial flow microfluidic devices for cellular isolation in liquid biopsies
Authors: Sierra Agudelo Jessica Nathalia , Subirada Francesc , Hendriks Melanie , Rodriguez Trujillo Romen , Samitier Josep 
Published: November 2023

Microfluidic devices for biomedical applications manufactured by conventional lithography often lack flexibility in design integration. Limitations in aspect ratio or in the ability to integrate microfluidic elements located in different planes reduce the available design options. Regarding this, 3D printing offers several advantages over traditional fabrication techniques. However, 3D printing technologies indeed show some limitations in the resolution of the microstructures obtained in comparison with standard lithography. We have optimized a low-cost multi-system combining standard lithography and 3D printing to design inertial flow microfluidic devices with different channels dimensions for cell concentration or isolation in blood, which are adaptable to cancer tumor cell (CTC) detection in liquid biopsies. CTC separation from complete blood using microfluidic devices often faces the challenge of leukocyte contamination due to their similar size with CTC. However, with 3D printing, we can create larger channels than those produced through lithography, enabling the use of beads coated with antibodies that bind to leukocytes expressing the CD45+ receptor. This binding results in larger particles that could be separated from the CTCs in the microfluidic devices, providing a more purified CTC sample. Microfluidic spiral structures were obtained with standard lithography for a first purification step using rectangular channel of 152 µm height and 500 µm width channels. The blood samples after processingE were analyzed by flow cytometry and revealed a recovery efficiency using two different CTC models of 80% ± 4% and 95% ± 4%. Also, the system enables 97.5% ± 1.89% and 83.4% ± 3.6% depletion of erythrocytes and leukocytes respectively. In addition, single or double microfluidic spiral structures to reduce leukocyte contamination using beads were directly fabricated using stereolithography 3D printing. In the single device with a channel of 600 μm and 1.4 mm of height and width respectively, and in the case of the device with two spirals placed on different planes, with a channel of 800 μm and 1.4 mm of height and width respectively. In addition, a read-out system based on an electronic circuit with piezoelectric micropumps, and a low-cost optical microscope was designed and adapted. This configuration avoids usual limitations when using syringe pumps and big microscopes, such as lack of sample recirculation, loss of CTCs during stabilization, blood sedimentation in the syringe, and reduced portability. Finally, combining a microfluidic spiral to separate red blood cells and partially leucocytes with the 3D microfluidic spiral to separate particles as the beads coated with CD45+ antibodies, could be possible to achieve a total leukocyte depletion up to 91%, and a maximum recovery of cancer cells up to 95%.
Predictors of Suboptimal Adherence Among Children on Antiretroviral Therapy in Southern Ethiopia: A Multicenter Retrospective Follow-Up Study
Authors: Guyo Tamirat Gezahegn , Merid Fasika , Toma Temesgen Mohammed 
Published: November 2023

Objectives: Despite increased access to and availability of antiretroviral therapy, the program’s effectiveness is primarily affected by treatment adherence. Therefore, this study aimed to determine the magnitude and predictors of suboptimal adherence among children on ART in Southern Ethiopia.Methods: A multicenter retrospective study was conducted among human immunodeficiency virus (HIV) infected children in Gamo and South Omo zone public health facilities. To identify factors associated with suboptimal adherence, a binary logistic regression model was fitted. Variables with a p-value ≤0.25 in bivariable logistic regression analysis were included in multivariable logistic regression analysis. p-value &lt;0.05 was used to declare statistical significance.Results: The suboptimal adherence was determined to be 30.3% (95% CI: 25.5%, 35.6%). Advanced clinical stage, hemoglobin level &lt;10 mg/dL, unchanged initial regimen, and non-disclosure of HIV sero-status were significant predictors of suboptimal adherence.Conclusion: Suboptimal adherence is a significant public health problem in the study setting. Therefore, designing interventions towards improving adherence is needed especially for children with poor clinical characteristics.
First Report of aac(6′)-Ib and aac(6′)-Ib-cr Variant Genes Associated with Mutations in gyrA Encoded Fluoroquinolone Resistance in Avian Campylobacter coli Strains Collected in Tunisia
Authors: Gharbi Manel , Abbas Mohammed Abdo Saghir , Hamrouni Safa , Maaroufi Abderrazak 
Published: November 2023

The aac(6′)-Ib gene is the most widespread gene encoding aminoglycoside-modifying enzyme and conferring resistance to tobramycin, streptomycin and kanamycin. The variant aac(6′)-Ib-cr gene confers resistance to both aminoglycosides and fluoroquinolones (FQ). A total of 132 Campylobacter isolates, including 91 C. jejuni and 41 C. coli, were selected from broiler hens isolates. The aac(6′)-Ib gene was amplified using PCR and was subsequently digested with the BtsCI restriction enzyme to identify aac(6′)-Ib-cr. Among these isolates, 31 out of 41 C. coli (75.6%) and 1 (0.98%) C. jejuni were positive for the aac(6′)-Ib gene, which was identified as the aac(6′)-Ib-cr variant in 10 (32.25%) C. coli isolates. This variant was correlated with mutations in gyrA (Thr-86-Ile), as well as resistance to FQs. This study is the first report in Tunisia on Campylobacter coli strains harboring both the aac(6′)-Ib and aac(6′)-Ib-cr variants. These genes were present in Campylobacter isolates exhibiting resistance to multiple antibiotics, which restricts the range of available treatments.
À propos de l’autorité dans l’Église
Authors: Schlumberger Laurent 
Published: November 2023

Dans cet exposé initialement destiné à un séminaire d’inspecteurs ecclésiastiques luthériens et de présidents de conseils régionaux réformés (des pasteurs dont la tâche est pour partie de type épiscopal), la question de l’autorité dans l’Église est abordée sous un angle pragmatique.
En effet, si, selon la Réforme, Christ seul a autorité dans l’Église sans que cette autorité soit déléguée à quiconque, où et comment cette autorité se manifeste-t-elle dans la vie de l’Église ?
Laurent Schlumberger propose de voir dans l’interprétation et le discernement les deux lieux principaux de cette manifestation. A partir de son expérience de président de conseil régional dans l’ERF, il propose de distinguer, pour mieux les articuler, les fonctions d’autorité et de pouvoir au sein de l’Église.
À la découverte de la source commune. Le message de Jésus
Authors: Babut Jean-Marc 
Published: November 2023

Discovering the common source : the message of Jesus.
With the help of a well-tested method of analysis, Jean-Marc Babut attempts to clarify the semantic content of the expression basileia tou theou used frequently in the text of Q as it has been reconstituted in The Critical Edition of Q. Ordinarily translated by “Rule or Kingdom of God” in traditional versions of the Bible, basileia tou theou actually points to some basically present reality with great promise for the future.
Pitavastatin: What Do We Need to Know?
Authors: Пристром А.М. 
Published: November 2023

В статье рассматриваются основные характеристики питавастатина – статина нового поколения. Показаны особенности его фармакологического действия, позволяющие на фоне снижения уровня холестерина липопротеидов низкой плотности более эффективно по сравнению с другими статинами влиять на другие показатели липидного обмена – снижать уровень триглицеридов и повышать уровень холестерина липопротеидов высокой плотности. В статье показаны преимущества питавастатина по сравнению с другими статинами за счет меньшего числа межлекарственных взаимодействий, а также лучшая переносимость. В работе приводится современный накопленный опыт применения питавастатина в крупных клинических исследованиях, на основании которого представлена его гиполипидемическая активность, а также показаны его клинические преимущества в управлении атерогенной дислипидемией и снижении высокого сердечно-сосудистого риска по сравнению с другими представителями класса статинов и область применения препарата.
The article discusses the main nutritional characteristics of pitavastatin, a new generation statin. The features of its pharmacological action are shown, which allow, against the background of a moderate decrease in the level of low-density lipoprotein cholesterol, to more effectively influence other indicators of lipid metabolism in comparison with other statins – to reduce the level of triglycerides and increase the level of high-density lipoprotein cholesterol. The article shows the nutritional benefits of pitavastatin compared to other statins due to fewer drug-drug interactions, as well as better tolerability. As a result of current accumulated nutritional experience, large medical studies have shown pitavastatin to have lipid-lowering activity, as well as its benefits in the treatment of atherogenic dyslipidemia and the reduction of high cardiovascular risk compared to other statins and the scope of the drug.
INVESTIGATING THE RELATIONSHIP BETWEEN TOTAL QUALITY MANAGEMENT (TQM) AND HUMAN RESOURCES MANAGEMENT (HRM) IN LEBANESE COMPANIES
Authors: Helal Istivani 
Published: November 2023

Increasing customer satisfaction, efficiency, and market competitiveness are possible outcomes of Total Quality Management. On the other hand, TQM is an organized way to ensure that an organization's internal processes are continually improved. As a result of TQM, the quality of services and products may be improved while decreasing operational costs by enhancing human resources, processes, and equipment.
A quantitative methodology was employed to collect data. The sample size currently comprises 5% of the total workforce contacted to gather data. Researchers selected 120 participants using a cluster sample. The questionnaire had been coded using the Likert Scale ranging from 1 (Strongly Agree) to 5 (Strongly Disagree).The SPSS software has been utilized to analyze the data collected, and the results will be viewed in terms of regression analysis
The research findings showed that total quality management directly affects the performance of employees in the organizations. Training and development programs are interconnected as if the workers are motivated by workplace programs that help enhance their performance and strengthen their professions.
Compensation benefits and performance appraisals are two key elements that encourage staff to increase productivity. If the employee is satisfied, they will be kept at work and encouraged to pursue training and development programs, improving organizational performance and reducing turnover.
FACTORS INFLUENCE CHINESE TOURIST USING SOCIAL MEDIA IN TOURISM-RELATED: CASE OF SINA WEIBO
Authors: Yang Caiying , Sungsuwan Tinikan 
Published: November 2023

Social media plays an important role in consumer relations for the tourist industry in China. In the last decade, Chinese people have got used to visiting social media they trust before they make decisions on travelling. This trend, on the one hand, challenges traditional marketing strategies in the tourist industry; on the other hand, it also offers a great opportunity to take an insight into travellers’ behaviors affected by content from social media. So, there is a need in understanding how social media influences traveller’s behaviors. It is topical not only for people in the tourist industry in China but also in the rest of the world. In order to respond to the call stated above, this thesis examines the largest Chinese social media platform (by the number of users and monthly active users) Sina Weibo, and how its tourist content influence traveller’s behaviours. It will adopt a modified version of the Unified Theory of Acceptance and Use of Technology (UTAUT) to look into the results of the users surveyed by Sina Weibo. The results suggest that the variables such as Effort Expectancy (EE), Social Influence (SI), Facilitating Condition (FC), and Information Quality (IQ) have a positive influence on Behavioural Intention (BI), which means the above factors will influence people’s travel choices when using Sina Weibo. It also proposes recommendations based on the received results for further study and applications.