bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming obstacles in rare disease clinical trials
Authors: Barrett Timothy 
Published: October 2023

Overcoming obstacles in rare disease clinical trials
With an urgent need to develop new treatments for people with rare diseases, the University of Birmingham’s Professor Timothy Barrett explains how a new consortium will provide a step change in the delivery of rare disease clinical trials. Amina was diagnosed with diabetes when she was four years old. Her parents were told she had type 1 diabetes, the commonest form in childhood, and learnt to inject her with insulin several times a day. They had many sleepless nights checking her blood glucose in case it went too low. Unfortunately, aged ten years, she began to lose her vision, and family photos showed her on holiday at the seaside using a white stick. She was diagnosed with Wolfram syndrome, a rare genetic disease. This is a progressive degenerative disorder without treatment, and people die prematurely from complications.
The secrets of hydropower and PTX in Greenland
Authors: Andersen-Aagaard Claus 
Published: October 2023

The secrets of hydropower and PTX in Greenland
Greenland is a prime location for large-scale hydropower projects. Renewable energy investment possibilities are, therefore, abundant, writes Claus Andersen-Aagaard, Chief Executive Officer of GreenLead. One of the lesser-known facts about the Arctic is its potential to solve a part of the climate crisis. Melting glaciers, high up in mountain ranges, create the perfect conditions for large-scale hydropower. With a government actively looking for investors, it is a wonder that over 60 well-documented renewable energy opportunities continue to be known by so few. Greenland is home to some of the planet’s most extensive and untouched natural landscapes. Its abundant water resources, including vast glaciers and numerous rivers, make it an ideal location for large-scale hydroelectric power projects.
Innovative gene therapy approaches for brain tumour-related epilepsy
Authors: Cunningham Mark , Connor Kate 
Published: October 2023

Innovative gene therapy approaches for brain tumour-related epilepsy
Professor Mark Cunningham and Dr Kate Connor from Trinity College Dublin discuss the burden of brain tumour-related epilepsy and why novel therapies are urgently needed to improve the quality of life for those affected. Brain tumour-related epilepsy (BTRE) is a unique and devastating condition which embraces two serious pathologies. BTRE incidence is inversely correlated to malignancy, with seizures as the first presenting symptom in 65-85% of patients with low-grade gliomas (LGG) and 30-60% with glioblastoma (GBM). (1) Seizures often manifest as complications throughout brain tumour evolution. Clinical management via radiotherapy, chemotherapy, and antiepileptic drugs (AEDs) can reduce seizure frequency, but many patients continue to experience seizures following therapeutic intervention. (2) Overall, BTRE is a debilitating and difficult-to-control condition, with seizures closely linked to tumour recurrence and progression.
Healthy aging and physical activity practice: The missing link
Authors: Dionne Isabelle J 
Published: October 2023

Healthy aging and physical activity practice: The missing link
Isabelle J. Dionne, PhD, Professor, Université de Sherbrooke, walks us through physical activity practice and how it impacts research on healthy aging. Major public health agencies around the world urge the older population to get on the move while cities and states invest more and more in safe and attractive infrastructures and programs. Nonetheless, physical activity (PA) levels of aging adults remain low in most developed societies. It appears that the healthcare systems and the general public do not take advantage of the skills and competencies of qualified PA professionals trained in universities around the globe to support evidence- based physical activity practice and healthy aging. This weakest link needs reinforcement.
The sustainable catalyst-cased chemical industry
Authors: Dominguez Benetton Xochitl 
Published: October 2023

The sustainable catalyst-cased chemical industry
Dr Xochitl Dominguez Benetton, Senior Scientist and Project Coordinator from the Flemish Institute for Technological Research, walks us through the sustainable catalyst-based chemical industry which is very much a part of the FIREFLY project. In January 2023, funded with over €11 million by the Horizon Europe Programme, the FIREFLY project launched with an unwavering aim: transforming the catalyst-based chemical industry. By harnessing renewable energy for (electro)catalyst production from secondary resources, FIREFLY promises reduced costs and decreased reliance on metals and fossil fuels. This pioneering step toward circularity reimagines profitability by recycling industrial catalysts, forging a sustainable path for future industrial developments.
Fresh prepreg multilayer scrap reuse
Authors: Casanova Álvaro Calero 
Published: October 2023

Fresh prepreg multilayer scrap reuse
To address waste generated during production, a processing route for uncurde material is developed in MC4. Multilayer fresh prepreg scrap is processed to obtain new intermediate products that can be used to manufacture new parts. Developing dedicated valorisation processes for each composite scrap is essential to exploit their potential and avoid decreasing the remaining performances during processing or increasing costs. In the case of multilayer fresh prepreg scrap, it is typical of the aeronautical field in which automated lay-up technologies such as automatic fibre placement or automated tape laying create a flat stack with a tailored laminate. This laminate is then cut by ultrasonic equipment. Despite being high-quality, the leftovers remaining are discarded because of the complexity of finding a suitable application for these cutoffs and the complicated geometry of laminate parts. It must also be considered that this kind of scrap is often designed to keep a predominant orientation, presenting a higher amount of fibre.
Quality control for the recycling of carbon fibre
Authors: Eitzinger Christian 
Published: October 2023

Quality control for the recycling of carbon fibre
Due to the inevitable variability of the end-of-life input material, the resulting recycled fibre and nonwoven or woven material will have a higher degree of variability than virgin material. To make sure such recycled fabric is usable for high-quality applications, additional methods for quality control are required. Existing methods for quality control, such as the Profactor FScan sensor, are used to detect a range of different types of deviations during the manufacturing of carbon fibre fabric. Such sensors can be integrated into weaving machines to cover the whole width of the material (e.g. up to 2.5m) and identify defects in real time.
Stress and coping during COVID-19
Authors: Adriaansen Marian 
Published: October 2023

Stress and coping during COVID-19
Marian Adriaansen and Henk Poppen from HAN University of Applied Sciences discuss their research on how Bachelor’s students in nursing coped with the impact of the COVID-19 pandemic. During the COVID pandemic, nurses were called upon to maintain patient and self-safety and quality of care in stressful circumstances. Bachelor’s students in nursing were also initially confronted with a situation that was new to them, and they were unable to draw on previous practical experiences. The question was how they dealt with this situation and whether this led to more stress or to a more negative image of their profession.
The Mediterranean Diet (MedDiet): There’s more to it than olives and grape leaves
Authors: Kaufman Mildred , Keyserling Thomase C 
Published: October 2023

The Mediterranean Diet (MedDiet): There’s more to it than olives and grape leaves
Centered around the consumption of whole and unprocessed foods, we hear how following a Mediterranean diet can bring long-term health benefits, including mitigating the risk of common diseases. The popular press seems to publish articles daily about the Mediterranean diet. This eating pattern has been shown to reduce the risk of many of our most formidable health problems, including diabetes, hypertension, cancer, heart disease, and even depression. (1) In January 2023, the New York Times published an article: The Mediterranean Diet Really Is that Good for you. Here’s Why, (2) describing the many benefits of this “bedrock of virtuous eating.” Many nutrition professionals prefer to call the MedDiet an eating pattern rather than a “diet”, which implies a restrictive and onerous weight loss diet. If you are “on a diet,” there will likely be a time, or many times, when you are “off” the diet, while an eating pattern reflects long-term habits.
Post-pandemic MERS-CoV still presents risks
Authors: Falzarano Darryl 
Published: October 2023

Post-pandemic MERS-CoV still presents risks
Darryl Falzarano, Research Scientist at the Vaccine and Infectious Disease Organization (VIDO), discusses potential solutions that are needed to tackle the coronavirus known as MERS-CoV. The COVID-19 pandemic rapidly brought new tools to protect us from coronaviruses – in the form of effective vaccines and antivirals. While these preventatives and therapeutics provide a basis for the future development of additional countermeasures, current data suggests that these advances do not offer much assistance against another, much more pathogenic coronavirus, known as Middle East respiratory syndrome coronavirus (MERS-CoV). Since its discovery in 2012, there have been 2,605 reported cases of MERS-CoV, with most cases occurring in the Arabian Peninsula. The comparatively small number of cases has resulted in 936 deaths – a very high (35%) case-fatality rate.
The crucial role of scavengers in ecosystem health
Authors: Lynch Laurel 
Published: October 2023

The crucial role of scavengers in ecosystem health
Animal scavengers’ role in maintaining ecosystem balance is often overlooked. Dr Laurel Lynch from the University of Idaho tells us about her important research on how scavenging by Tasmanian devils influences ecosystem processes. Declines in biodiversity threaten the function of ecosystems worldwide. Species populations have declined by ~68% globally since 1970, and humans and their livestock now account for ~97% of Earth’s biomass. Declines of top predators and scavengers are of particular concern because their loss can have devastating impacts on ecological and economic services, including secondary declines of other species, increases in disease spread, and changes in nutrient cycling that can affect food production. However, more research is needed to understand how the complex interactions among species and their environment produce the balanced, well-functioning ecosystems upon which humans depend.
The role of hydrogen in the energy transition
Authors: Walker Sara Louise 
Published: October 2023

The role of hydrogen in the energy transition
Professor Sara Walker, Professor of Energy at Newcastle University, is Director of the Hub on Hydrogen Integration for Accelerated Energy Transitions HI-ACT, and here, she explores the role of hydrogen in the energy transition. Across the globe, we continue to see the impacts of climate change. As I write, devastating fires in Hawaii are the most recent example, but there are many. Globally, energy use is estimated to contribute more than three-quarters of greenhouse gas emissions. So, mitigation of climate change often focuses on energy efficiency, transition away from fossil fuels to renewables, and electrification of demand. At HI-ACT, our vision is to ensure that hydrogen and hydrogen-based alternative liquid fuels are appropriately integrated into a future equitable energy system through holistic multi-disciplinary research.
Pelagics: What are the opportunities and challenges?
Authors: Rustad Turid 
Published: October 2023

Pelagics: What are the opportunities and challenges?
Turid Rustad from the Norwegian University of Science and Technology provides an overview of pelagic fish and the impact of the growing global demand for food. Pelagic fish are fish that live in the pelagic zone of oceans or lakes – that is, in the open part of the oceans. The pelagic zone makes up the main part of the oceans, and therefore, a large number of species live in this zone. Some of the pelagic fish live in areas close to the coast – that is, at depths of around 200 m while other species live in the open ocean and at depths below the continental shelf. The coastal group of fish includes anchovies, sardines, shad and menhaden, while tuna, mackerel, swordfish and sharks belong to the ocean group, however, there are no strict boundaries between the groups.
West Antarctica’s contribution to sea level rise as Earth’s climate warms
Authors: Lubin Dan 
Published: October 2023

West Antarctica’s contribution to sea level rise as Earth’s climate warms
Dr Dan Lubin, Researcher at the Scripps Institution of Oceanography, explores the contribution of West Antarctica to sea level rise as Earth’s climate warms. Sea level rise (SLR) is one of the most pressing concerns with greenhouse gas-induced climate warming. Over one-third of the human population, including nearly two-thirds of the global urban population, lives within 100 km of the sea. SLR increases flooding from storm surges and high tides, deterioration of infrastructure, shoreline erosion, contamination of agriculture, and numerous other hardships. Climate warming causes SLR in two primary ways: the melting of polar ice sheets and glaciers and the thermal expansion of the ocean as it warms. The two largest contributors to SLR from the steadily warming polar regions are the Greenland Ice Sheet (GIS) and the West Antarctic Ice Sheet (WAIS), at approximately 280 and 160 gigatons of ice per year, respectively. The GIS and WAIS have contrasts in the details of their ice mass loss.
Next-generation climate services, regional to local scale
Authors: Harrs Jan-Albrecht , Tiedje Bente , Reinhart Vanessa 
Published: October 2023

Next-generation climate services, regional to local scale
Here, we discover how Climate Service Center Germany (GERICS) develops next-generation climate services from the regional to local scale. The EU aims to transform 150 European regions and cities into sustainable and climate-resilient areas by 2030. Many extreme events across the globe in the past years demonstrate the impacts of climate change across sectors, but especially at the local level. Hence, regional and local city officials are challenged with a pressing need to identify risks, plan, and implement efficient adaptation measures. To identify future exposure, vulnerability and plan appropriate measures, climate data (including climate model and observational data) needs to be combined with socio- economic and the respective local geographical data (e.g., on topography or land use).
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG VÀ HÌNH ẢNH CẮT LỚP VI TÍNH UNG THƯ VÒM TRƯỚC XẠ TRỊ TẠI BỆNH VIỆN UNG BƯỚU THÀNH PHỐ CẦN THƠ NĂM 2022-2023
Authors: Phạm Thới Thuận , Huỳnh Quang Huy 
Published: October 2023

Đặt vấn đề: Ung thư vòm là khối u ác tính vùng hầu mũi được xem là một trong 10 loại ung thư thường gặp nhất. Phần lớn đều phát hiện trong giai đoạn muộn do đặc điểm lâm sàng và hình ảnh học phức tạp. Mục tiêu nghiên cứu: Mô tả đặc điểm lâm sàng và hình ảnh cắt lớp vi tính trên bệnh nhân ung thư vòm trước xạ trị tại Bệnh viện Ung bướu thành phố Cần Thơ năm 2022-2023. Đối tượng và phương pháp nghiên cứu: Báo cáo loạt ca 30 trường hợp mắc ung thư vòm đến khám và điều trị tại tại Bệnh viện Ung bướu thành phố Cần Thơ từ tháng 08/2022 đến tháng 04/2023. Kết quả: Về đặc điểm lâm sàng, hạch cổ (68,8%) là triệu chứng làm người bệnh khó chịu đến nhập viện. Bên cạnh đó các đặc điểm này được ghi nhận bao gồm vị trí cảnh giữa (41,7%) và cảnh dưới (35%), có mật độ chắc (91,7%), kém hoặc ít di động. Về hình ảnh học: Giai đoạn lâm sàng chủ yếu là giai đoạn III và IVa chiếm tỷ lệ khoảng 1/3 số đối tượng. Phân bố theo T và N, giai đoạn N2 và N3 được xem là ghi nhận được trên 2/3 đối tượng (tương ứng 36,7% và 30%). Kết luận: Triệu chứng lâm sàng gặp nhiều nhất là hạch cổ 80%. Người bệnh chủ yếu phát hiện ở giai đoạn lâm sàng III và IV với 80% người bệnh. Những người bệnh này phát hiện chủ yếu ở giai đoạn 6 tháng 80%. Vị trí khối u thường gặp nhất là ở trần vòm thành bên và hình ảnh thấy trên khối u là thể sùi.
Tema broja: Demografske karakteristike seoskog stanovništva Jugoslavije
Authors: Rašević Mirjana 
Published: October 2023

Pred vama је prvi tematski broj časopisa Stanovništvo u njegovoj, više od tri decenije dugoj, tradiciji izlaženja. Posvećen је Demografskim karakteristikama seoskog stanovništva Jugoslavije iz najmanje dva razloga. То је, pre svega, tema kojoj, u dosadašnjim istraživanjima populacionih procesa, nije posvećena dužna pažnja. Sem toga, u stručnoj i političkoj javnosti sve se vise govori о potrebi revitalizacije sela, za koju је poznavanje demografske osnove neophodna pretpostavka.
Radovi i prilozi u ovom broju su inicirani od strane redakcije. Pritom smo imali u vidu kako značaj pojedinih podtema, tako i istraživačka opredeljenja autora. Otuda је sadržajem obuhvaćen niz pitanja od onih metodološke prirode, preko sagledavanja osobina razvitka stanovništva sela, uz izdvajanje osnovnih problema, do otvaranja pitanja vezanih za mere i akcije koje bi bile neophodne da država preduzima u cilju obnavljanja i jačanja demografskih potencijala sela.
Predajući ovaj broj časopisa Stanovništvo u javnost zahvaljujemo se svima onima koji su omogućili njegovo izlaženje; pre svega autorima, kao i Ministarstvu za nauku i tehnologiju Vlade Republike Srbije i Saveznom ministarstvu za razvoj, nauku i životnu sredinu. U nadi da ćе ovako koncipiran broj biti prihvaćen, redakcija ima nameru da i ubuduće pokreće tematske brojeve časopisa Stanovništvo.
Dr Mirjana Rašević, urednik
A Review on Revolutionize Drug Delivery with Spansules
Authors: A. Bhadoriya , T. Shukla 
Published: October 2023

This article provides a brief overview of Spansules, a novel drug delivery system. Spansules are designed to release medication in a controlled manner, providing a sustained and consistent therapeutic effect. This delivery method involves encapsulating the drug in a special coating that dissolves slowly, allowing the medication to be released gradually over time. Spansules have been shown to improve patient compliance and reduce side effects associated with traditional drug delivery methods. Spansules are classified as an Advanced Drug Delivery System due to their ability to facilitate controlled and sustained release of medication over an extended duration. The delivery system in question has the capability to maintain a consistent plasma drug concentration across a broad time spectrum. This attribute can enhance the effectiveness of treatment and mitigate the likelihood of adverse reactions. Spansules can be utilized for the delivery of multiple drugs in a single dosage form, while also providing sustained release. The Spansules product offers a multi-drug regimen capability, which enables the administration of multiple drugs in a single dosage form, providing added benefits. Spansules are a type of biphasic release drug delivery system that enables the administration of medication in both immediate and sustained release forms. In situations where a patient necessitates prompt alleviation of symptoms followed by sustained management over an extended duration, these systems can prove to be advantageous. In general, Spansules represent a versatile and efficacious mechanism for drug delivery that can offer numerous advantages to both patients and healthcare providers. Overall, Spansules represent a promising advancement in the field of drug delivery.
Fatores condicionantes da atuação docente na implementação das trilhas de aprofundamento do novo Ensino Médio
Authors: Heinrichs Marcelo Martin , Da Silva Arleide Rosa 
Published: October 2023

O presente texto está inserido no contexto de Implementação das Trilhas de Aprofundamento, parte dos Itinerários Formativos do Novo Ensino Médio. Busca evidenciar quais os fatores condicionantes da atuação docente para a Implementação das Trilhas de Aprofundamento, a partir da visão dos professores da área de Ciências da Natureza e suas Tecnologias, de três escolas piloto da Coordenadoria Regional de Educação de Seara, da Rede Estadual de Ensino de Santa Catarina, atuantes nas Trilhas. A pesquisa delineou-se como sendo de caráter qualitativo sendo que os dados foram gerados por meio de três ferramentas distintas: questionário aplicado via google formulários; entrevista semiestruturada e, uma observação participante realizada durante os planejamentos coletivos, com registros em um diário de bordo. O número de professores envolvidos na pesquisa foi de 7 (sete). Para realizar o tratamento dos dados, foi utilizada como metodologia a Análise de Conteúdo. Dentre os fatores condicionantes identificados, pode-se destacar: o grande número de professores ACTs, a pouca experiência de alguns professores, a necessidade de movimentos de formação continuada em contexto, a importância de ter à disposição espaços de planejamento coletivo, bem como, estrutura física, recursos didáticos e material adequado. Com os dados aqui apresentados, dispõe-se de suporte para afirmar que, o distanciamento e o silenciamento acerca destes elementos dificultará o processo de implantação das Trilhas na Rede Pública Estadual de Santa Catarina.
Development and Validation of a Scale Measuring the Attitude of farmers towards Climate Smart Agriculture
Authors: Rohit  , Singh Harish Chandra , Singh Mayank , Asha Kumari , Singh Shani Kumar , Abhijeet  
Published: October 2023

The measurement of attitudes is a critical endeavour in the realm of social and psychological research, enabling a deeper understanding of human behaviours, preferences, and beliefs. Constructing a reliable and valid scale to assess attitudes requires a systematic approach that encompasses various stages, such as conceptualization, item generation, scale refinement, pilot testing, psychometric analysis, and validation. A summated (Likert) rating scale was used to develop the scale. A total of 60 statements, consisting of 45 positive and 15 negative statements, were framed, of which 22 statements (19 positive and 3 negative) were retained in the final scale. The reliability of the scale was calculated by using the split-half method. The validity of the scale was tested by experts’ judgment. The psychometric properties of the scale include: the Pearson product-moment correlation between two sets was 0. 0.598; reliability of the test 0.748(P<0.01) and Cronbach = 0.759, which means the scale is consistent in measurement. This scale can be used to measure the attitude of students in similar situations outside the study area with suitable modifications.