bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective factors for suicidal ideation: a prospective study from adolescence to adulthood
Authors: Bakken Victoria , Lydersen Stian , Skokauskas Norbert , Sund Anne Mari , Kaasbøll Jannike 
Published: February 2024

AbstractAdolescent suicidality is associated with negative outcomes in adulthood. Suicide prevention has traditionally focused on identifying risk factors, yet suicide rates have remained stable. With suicidality often going undetected—especially suicidal ideation, further knowledge about protective factors is needed. The main objective of this study was to investigate potential protective factors for suicidal ideation from adolescence to adulthood. The study employed longitudinal population survey data, “Youth and Mental Health Study” consisting of self-reports at two-time points (mean age 14.9, SD = 0.6 and 27.2, SD = 0.6) (n = 2423 and n = 1198). Protective factors (at individual, social and environmental level) were selected based on a priori knowledge. Internal consistency of scales was analyzed using McDonald’s omega. We used a linear mixed model with suicidal ideation as the dependent variable, time-points, a protective factor variable and their interaction as covariates, and individual participant as random effects. We adjusted for sex and also conducted separate analyses for males and females. The Benjamini–Hochberg procedure was used to adjust p-values for multiple hypotheses. Investigated protective factors were associated with temporal change in suicidal ideation (significant interactions). For both sexes, less emotion-orientated coping, higher self-perception scores, greater levels of physical activity and higher school wellbeing/connectedness were protective factors for suicidal ideations. Secure attachment and higher family function were protective factors for females only. The effects in adolescence were mostly maintained in adulthood. In this study, several protective factors for suicidal ideation persisted into adulthood, with distinct differences between males and females.
Barriers to and facilitators of user engagement with web-based mental health interventions in young people: a systematic review
Authors: Ho Thi Quynh Anh , Le Long Khanh-Dao , Engel Lidia , Le Ngoc , Melvin Glenn , Le Ha N. D. , Mihalopoulos Cathrine 
Published: February 2024

Abstract
Many young people (YP) are diagnosed with mental illnesses and require support. Web-based mental health interventions (W-MHIs) have been increasingly utilized by YP, healthcare providers, and parents due to reasons including convenience and anonymity. W-MHIs are effective in improving mental health in YP. However, real-world engagement with W-MHIs remains low. Therefore, understanding barriers/facilitators of user engagement with W-MHIs is necessary to promote W-MHIs and help users gain optimal benefits through higher engagement. This review aims to identify barriers/facilitators of user engagement with W-MHIs in YP aged 10–24 years. A systematic search of five databases for English language, peer-reviewed publications was conducted between January 2010 and February 2023. Studies examining factors influencing user engagement with W-MHIs, described as barriers or facilitators, were included. Study quality was assessed using the Mixed Methods Appraisal Tool. A narrative synthesis was performed. Of 4088 articles identified, 69 studies were included. Barriers/facilitators were reported by young people (63 studies), providers (17 studies), and parents/caregivers (8 studies). YP perceived that usefulness and connectedness were the most common facilitators, whereas low-perceived need was the most reported barrier. Both providers and parents reported that perceived usefulness for YP was the most common facilitator, whereas concerns about program effectiveness and privacy were noted as barriers. This review found that program- and individual-related factors were important determinants of engagement with W-MHIs. This review provides guidance on the future design and development of new interventions, narrowing the gap between existing W-MHIs and unmet needs of users.
LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma
Authors: Jin Dong , Hui Yongfeng , Liu Di , Li Nan , Leng Junzhi , Wang Genwang , Wang Qi , Lu Zhenhui 
Published: February 2024

AbstractHepatocellular carcinoma (HCC) is a common malignant tumor with a high recurrence rate and a poor prognosis. Long intergenic nonprotein coding RNA 942 (LINC00942) is reported to be related to ferroptosis and the immune response in HCC and serves as an oncogene in various cancers. This research aimed to explore the contribution of LINC00942 in HCC progression. Functional assays were used to evaluate the functional role of LINC00942 in vitro and in vivo. Mechanistic assays were conducted to assess the association of LINC00942 with insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) and solute carrier family 7 member 11 (SLC7A11) and the regulatory pattern of LINC00942 in HCC cells. LINC00942 was found to exhibit upregulation in HCC tissue and cells. LINC00942 facilitated HCC cell proliferation, suppressed ferroptosis, and converted naive CD4+ T cells to inducible Treg (iTreg) cells by regulating SLC7A11. Furthermore, SLC7A11 expression was positively modulated by LINC00942 in HCC cells. IGF2BP3 was a shared RNA-binding protein (RBP) for LINC00942 and SLC7A11. The binding between the SLC7A11 3′ untranslated region and IGF2BP3 was verified, and LINC00942 was found to recruit IGF2BP3 to promote SLC7A11 mRNA stability in an m6A-dependent manner. Moreover, mouse tumor growth and proliferation were inhibited, and the number of FOXP3+CD25+ T cells was increased, while ferroptosis was enhanced after LINC00942 knockdown in vivo. LINC00942 suppresses ferroptosis and induces Treg immunosuppression in HCC by recruiting IGF2BP3 to enhance SLC7A11 mRNA stability, which may provide novel therapeutic targets for HCC.
Effect of cancer cachexia on first-line chemotherapy in patients with advanced pancreatic cancer: a claims database study in Japan
Authors: Furuse Junji , Osugi Fumihiko , Machii Koji , Niibe Koji , Endo Toshimitsu 
Published: February 2024

Abstract
Background
Cancer cachexia is a multifactorial syndrome leading to progressive functional impairment. How cachexia affects the treatment course of chemotherapy in patients with pancreatic cancer has not been well understood.

Methods
This is an exploratory, retrospective, observational cohort study using the Japanese medical claims database from Medical Data Vision Co., Ltd. The study population included patients diagnosed with pancreatic cancer in whom first-line FOLFIRINOX (FFX) or gemcitabine plus nab-paclitaxel (GnP) was initiated between October 1, 2018, and September 30, 2020. In this study, we defined patients with cancer cachexia as those who had a weight loss of ≥ 5% in the preceding 6 months. The primary outcome was time-to-treatment failure (TTF). The observation period was six months from the initiation of first-line FFX or GnP treatment.

Results
A total of 1897 patients (421 patients into the cachexia group; 1476 patients into the non-cachexia group) were analyzed in this study. The median TTF was 121 days (95% confidence interval [CI] 94–146) in the cachexia group and 143 days (95% CI 134–152) in the non-cachexia group. The hazard ratio for TTF of the cachexia versus non-cachexia group was 1.136 (95% CI 0.979–1.319). The median number of doses was two doses fewer in the cachexia group than in the non-cachexia group for both FFX and GnP.

Conclusion
Cancer cachexia was suggested to be associated with shorter TTF and a reduced number of doses in patients with pancreatic cancer who received first-line FFX or GnP treatment.
Clinical Trial Registration clinicaltrials.jp: UMIN000045820.
Discrete network models of endothelial cells and their interactions with the substrate
Authors: Jakob Raphael , Britt Ben R. , Giampietro Costanza , Mazza Edoardo , Ehret Alexander E. 
Published: February 2024

AbstractEndothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are continuously exposed to different mechanical loads, which may trigger mechanobiological signals and hence play a role in both physiological and pathological processes. Computer-based mechanical models of cells contribute to a better understanding of the relation between cell-scale loads and cues and the mechanical state of the hosting tissue. However, the confluency of the endothelial monolayer complicates these approaches since the intercellular cross-talk needs to be accounted for in addition to the cytoskeletal mechanics of the individual cells themselves. As a consequence, the computational approach must be able to efficiently model a large number of cells and their interaction. Here, we simulate cytoskeletal mechanics by means of molecular dynamics software, generally suitable to deal with large, locally interacting systems. Methods were developed to generate models of single cells and large monolayers with hundreds of cells. The single-cell model was considered for a comparison with experimental data. To this end, we simulated cell interactions with a continuous, deformable substrate, and computationally replicated multistep traction force microscopy experiments on endothelial cells. The results indicate that cell discrete network models are able to capture relevant features of the mechanical behaviour and are thus well-suited to investigate the mechanics of the large cytoskeletal network of individual cells and cell monolayers.
Ecotypic variation in multiple traits of European beech: selection of suitable provenances based on performance and stability
Authors: Liepe Katharina J. , van der Maaten Ernst , van der Maaten-Theunissen Marieke , Kormann Jonathan M. , Wolf Heino , Liesebach Mirko 
Published: February 2024

AbstractInduced by climate change associated disturbances and further promoted by changes in forest management, the proportion of European beech, a highly competitive climax species, is increasing in Central Europe. However, its climatic stability is questioned by the recent loss of vitality. In this regard, the evaluation of seed sources used for reforestation receives great attention. Here, we present a multi-trait evaluation of height, basal area and stem quality assessed over 25 years for 85 provenances grown at three sites in northern, western and eastern Germany. Considerable provenance differentiation exists, explaining 21% (proportion of trees with acceptable stem form) to 45% (basal area) of the variance on single sites and 20 to 39% across sites, while provenance by environment interactions are absent. On the landscape level, this results in distinct patterns with spatially adjacent provenances showing a similar trait expression. These patterns are highly similar for height and basal area but divergent for stem form. They could be directly linked to geographic variables with multivariate regression tree analysis that captured 58% of the phenotypic variation, delineating eleven ‘ecotypes’ shaped by local adaptation. A selection based on two multi-trait indices gives highly concordant results. Particularly, the intermediate elevations of the central highlands in Western Germany host highly suitable provenances. Lower elevation provenances from continental climates in the south-east profit from the transfer to favorable growing conditions. Since the majority of provenances was already exposed to elevated temperatures compared to their origin during the observation period, this study gives a first indication for the potential benefits of assisted migration facing climate change.
Die Ausgestaltung der Regelungen über Erlaubnisse und Bewilligungen im Wasserhaushaltsgesetz
Authors: Gentile Matteo 
Published: February 2024

ZusammenfassungDas Gestattungsregime für Gewässerbenutzungen im Wasserhaushaltsgesetz ist hochgradig komplex.
Es erscheint mit seinen unterschiedlichen Zulassungsformen (Erlaubnis, gehobene Erlaubnis und Bewilligung),
deren Erteilung noch dazu an eine nahezu kaum beschränkbare Vielzahl von tatbestandlichen Voraussetzungen
anknüpft und zu guter Letzt auf der Rechtsfolgenseite auch noch von einer im Bewirtschaftungsermessen
der Wasserbehörde liegenden Entscheidung abhängt. Dieses Regime soll nachfolgend skizziert und
kritisch hinterfragt werden.
Advancing Adolescent and Young Adult HIV Prevention and Care and Treatment Through Use of Multi-level Theories and Frameworks: A Scoping Review and Adapted HIV Ecological Framework
Authors: Denison Julie A. , Willis Kalai , DeLong Stephanie M. , Sievwright Kirsty M. , Agwu Allison L. , Arrington-Sanders Renata , Kaufman Michelle R. , Prabhu Sandeep , Williams Ashlie M. , Fields Errol L. , Alexander Kamila A. , Lee Lana , Yang Cui ,   The Johns Hopkins University Center for AIDS Research Adolescent and Young Adult Scientific Working Group
Published: February 2024

AbstractWhile multi-level theories and frameworks have become a cornerstone in broader efforts to address HIV inequities, little is known regarding their application in adolescent and young adult (AYA) HIV research. To address this gap, we conducted a scoping review to assess the use and application of multi-level theories and frameworks in AYA HIV prevention and care and treatment empirical research. We systematically searched five databases for articles published between 2010 and May 2020, screened abstracts, and reviewed eligible full-text articles for inclusion. Of the 5890 citations identified, 1706 underwent full-text review and 88 met the inclusion criteria: 70 focused on HIV prevention, with only 14 on care and treatment, 2 on both HIV prevention and care and treatment, and 2 on HIV-affected AYA. Most authors described the theory-based multi-level framework as informing their data analysis, with only 12 describing it as informing/guiding an intervention. More than seventy different multi-level theories were described, with 38% utilizing socio-ecological models or the eco-developmental theory. Findings were used to inform the adaptation of an AYA World Health Organization multi-level framework specifically to guide AYA HIV research.
Deep learning for cancer cell detection: do we need dedicated models?
Authors: Karol Michal , Tabakov Martin , Markowska-Kaczmar Urszula , Fulawka Lukasz 
Published: February 2024

AbstractThis article proposes a novel concept for a two-step Ki-67/lymphocytes classification cell detection pipeline on Ki-67 stained histopathological slides utilizing commonly available and undedicated, in terms of the medical problem considered, deep learning models. Models used vary in implementation, complexity, and applications, allowing for the use of a dedicated architecture depending on the physician’s needs. Moreover, generic models’ performance was compared with the problem-dedicated one. Experiments highlight that with relatively small training datasets, commonly used architectures for instance segmentation and object detection are competitive with a dedicated model. To ensure generalization and minimize biased sampling, experiments were performed on data derived from two unrelated histopathology laboratories.
Routine Outcome Monitoring from Psychotherapists’ Perspectives: A Framework Analysis Study of Expected Benefits and Difficulties
Authors: Valdiviezo-Oña Jorge , Unda-López Alejandro , Montesano Adrián , Evans Chris , Paz Clara 
Published: February 2024

AbstractPsychotherapists’ attitudes and expectations towards routine outcome monitoring can impact the likelihood of its fruitful implementation. While existing studies have predominantly focused on Europe and North America, research in Latin America remains limited. The aim of this study is to explore therapists’ expected benefits and difficulties prior to implementing a routine outcome monitoring system in a university psychotherapy service in Ecuador. An exploratory and descriptive cross-sectional qualitative study was carried out with 20 participants aged 21 to 47. Semi-structured interviews were conducted to explore participants’ knowledge about routine outcome monitoring, their expectations of the difficulties, benefits, usability and risks of using a monitoring system, as well as their expectations about their role in the process. The data analysis adhered to the framework analysis methodology, leading to the identification of six overarching themes, 36 specific themes and 82 subthemes. The interviews highlighted a spectrum of positive and negative expectations at several levels: institutional/general, therapeutic process, therapists, and clients. Perceived benefits encompassed various aspects, including the availability of supplementary information, continuous adaptation of the therapeutic process, facilitation of organization and treatment planning, opportunities for professional development, and fostering patient trust and empowerment. On the other hand, anticipated difficulties comprised concerns such as discomfort among therapists and clients, increased workload, system usage and technical difficulties, and the risk of excessive quantification. Overall, participants expressed more anticipated benefits than difficulties. We present recommendations that can support and optimize the current local implementation efforts of routine outcome monitoring, both within this service and in other settings. These recommendations consider ways to meet positive expectations and address or mitigate negative ones.
Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study
Authors: Bruins Susanne , van Bergen Elsje , Masselink Maurits W. , Barzeva Stefania A. , Hartman Catharina A. , Otten Roy , Rommelse Nanda N. J. , Dolan Conor V. , Boomsma Dorret I. 
Published: February 2024

AbstractThere is a negative association between intelligence and psychopathology. We analyzed data on intelligence and psychopathology to assess this association in seven-year-old Dutch twin pairs (ranging from 616 to 14,150 depending on the phenotype) and estimated the degree to which genetic and environmental factors common to intelligence and psychopathology explain the association. Secondly, we examined whether genetic and environmental effects on psychopathology are moderated by intelligence. We found that intelligence, as assessed by psychometric IQ tests, correlated negatively with childhood psychopathology, as assessed by the DSM-oriented scales of the Child Behavior Check List (CBCL). The correlations ranged between − .09 and − .15 and were mainly explained by common genetic factors. Intelligence moderated genetic and environmental effects on anxiety and negative affect, but not those on ADHD, ODD, and autism. The heritability of anxiety and negative affect was greatest in individuals with below-average intelligence. We discuss mechanisms through which this effect could arise, and we end with some recommendations for future research.
Climate change from an ectotherm perspective: evolutionary consequences and demographic change in amphibian and reptilian populations
Authors: Hayden Bofill Sofía I. , Blom Mozes P. K. 
Published: February 2024

AbstractUnderstanding how natural populations will respond to contemporary changes in climate is becoming increasingly urgent and of fundamental importance for the preservation of future biodiversity. Among vertebrates, amphibians and reptiles are more sensitive to environmental perturbations than endotherms and ectotherm diversity will likely be disproportionally impacted by climate change. Notwithstanding concerns surrounding the climate change resilience of ectotherm populations, accurately predicting future population trajectories based on contemporary ecological and physiological data alone remains challenging and much can be learnt by studying how populations have responded to climate change in the past. Genomic approaches can now assay the genetic diversity of contemporary population at an unprecedented scale but to date have been relatively underutilised when studying the demographic history of amphibians and reptiles. In this review, we first summarise how changing climatic conditions may influence the ectotherm phenotype and how this can translate to changes in fitness and population dynamics. We then discuss how the relative role of past climate in shaping ectotherm diversity has traditionally been approached in a phylogeographic context and how expanding genomic resources for ectotherm species can be leveraged to improve the study of past demography for many amphibian and reptilian groups. An integrative approach that links known proximate effects on phenotype due to climate change, with past changes in demographic trajectories will ultimately enable us to generate more accurate models of future population change and improve our ability to assess climate change resilience for many ectotherm groups.
Uncertainties of Drag Coefficient Estimates Above Sea Ice from Field Data
Authors: Blein Sébastien , Guemas Virginie , Brooks Ian M. , Elvidge Andrew D. , Renfrew Ian A. 
Published: February 2024

AbstractSurface turbulent exchanges play a key role on sea ice dynamics, on ocean and sea ice heat budgets and on the polar atmosphere. Uncertainties in parameterizations of surface turbulent fluxes are mostly held by the transfer coefficients and estimates of those transfer coefficients from field data are required for parameterization development. Measurement errors propagate through the computation of transfer coefficients and contribute to its total error together with the uncertainties in the empirical stability functions used to correct for stability effects. Here we propose a methodology to assess their contributions individually to each coefficient estimate as well as the total drag coefficient uncertainty and we apply this methodology on the example of the SHEBA campaign. We conclude that for most common drag coefficient values (between $$1.0\times 10^{-3}$$

1.0
×

10

-
3

and $$2.5\times 10^{-3}$$

2.5
×

10

-
3

), the relative total uncertainty ranges from 25 and 50$$\%$$
%
. For stable or unstable conditions with a stability parameter $$|\zeta |>1$$

|
ζ
|
>
1

on average, the total uncertainty in the neutral drag coefficient exceeds the neutral drag coefficient value itself, while for $$|\zeta |<1$$

|
ζ
|
<
1

the total uncertainty is around 25$$\%$$
%
of the drag coefficient. For closer-to-neutral conditions, this uncertainty is dominated by measurement uncertainties in surface turbulent momentum fluxes which should therefore be the target of efforts in uncertainty reduction. We also propose an objective data-screening procedure for field data, which consists of retaining data for which the relative error on neutral drag coefficient does not exceed a given threshold. This method, in addition to the commonly used flux quality control procedure, allows for a reduction of the drag coefficient dispersion compared to other data-screening methods, which we take as an indication of better dataset quality.