bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uso de cloroquina, azitromicina e ivermectina durante a pandemia da COVID-19: Uma revisão integrativa
Authors: Reis Felipe , Rocha Junior Jailton de Jesus , Dominato Angélica Augusta Grigoli 
Published: December 2023

Durante a pandemia de COVID-19, a comunidade científica buscou veementemente por medicamentos que pudessem auxiliar no tratamento da doença em questão. Utilizaram-se medicamentos como cloroquina, azitromicina e ivermectina como automedicação, antes de confirmar sua eficácia contra o vírus e a doença. Após pouco mais de dois anos do início da pandemia mundial de COVID, a maneira como cuidamos da saúde, ainda levanta hipóteses, por parte da população, sobre as diversas formas corretas de lidar com a doença, afirmando que as diferentes abordagens seriam efetivas ou não? O objetivo reuniu evidências sobre a farmacocinética, mecanismo de ação proposto na COVID-19, efeitos adversos, eficácia e segurança da cloroquina/ hidroxicloroquina, azitromicina e ivermectina para profilaxia e tratamento da COVID-19. A metodologia usada foi uma revisão integrativa, que seguiu as recomendações da diretriz PRISMA adaptada. A busca na literatura foi conduzida nas bases de dados PubMed, LILACS e MEDLINE. Uma análise crítica foi realizada para apurar o rigor metodológico dos estudos, a partir da avaliação do nível das evidências científicas. Os resultados evidenciaram que o uso de hidroxicloroquina, cloroquina, azitromicina ou ivermectina, nas formas leve ou grave da COVID-19, tanto no tratamento como profilaxia, não demonstrou nenhum benefício na diminuição da mortalidade, hospitalizações ou outros desfechos desfavoráveis, não limitando a transmissão viral nem evitando a instalação da infecção. Concluindo que é contraindicado o uso destes medicamentos supracitados como medidas profiláticas e terapêuticas para a COVID-19, pela escassez de evidências favoráveis consistentes e pelos numerosos relatos de desfechos adversos em tais tratamentos.
The Presence of Protein A on The Surface of Staphylococcus Aureus Bacterial Cells Using Serum Soft Agar Techniques
Authors: Djannatun Titiek 
Published: December 2023

Protein A is a specific proteins on the surface of some Staphylococcus aureus (S. aureus) strains. Staphylococcus bacteria which have protein A has widely used in the biomedical. Aims of this study to find a simple method of detecting the presence of S. aureus protein A. 15 S. aureus isolates from field cases, S. aureus cowan I as positive control, Staphylococcus epidermidis dan Micrococcus sp as negatif control were used. Bacteria was inoculated into 10 ml Todd Hewith Broth medium, Soft Agar (SA) and into 10 ml of serum soft-agar (SSA), agitated using a vortex and incubated at 37oC for 18-24 h. Form of colonies that grew was observed and categorized as compact and diffuse colonies. The colonies that suspected contain protein A conducted confirmation tests by Dot Blot. 7 isolates showed the change of colony formation from diffuse to compact in SSA (SA added rabbit or chicken serum), and 8 isolates remain diffuse. Dot Blot test positive. Protein A has the ability to bind the Fc fraction of IgG but not the IgY from birds. The binding of S. aureus and IgG could be demonstrated by the change of colony growth from diffuse before the addition of serum containing IgG in SA to compact after the presence of serum. Protein A on the bacterial cell surface bind the Fc-IgG caused steric hinderance of bacteria and expressed as compact colony formation in SA. SSA using mammalian sera can be used to discriminate the bacterial strains with or without protein A.
Pelatihan Dan Pemasangan Running Text Untuk Mushola Di RT. 06 RW. 04 Dampit Kabupaten Malang
Authors: Ananto Rhezal Agung , Muhammad Fahmi Hakim  , Masramdhani Saputra  , Asfari Hariz Santoso  , Aly Imron  
Published: December 2023

Program pengabdian pada masyarakat ini adalah Pelatihan Dan Pemasangan Runing Text Untuk Mushola Di Rt. 06 Rw. 04 Dampit Kabupaten Malang. Tepatnya di mushola yang digunakan warga untuk sholat 5 waktu, sholat tarawih, sholat idul adha dan beberapa kegiatan pengajian untuk warga di RT. 06 RW.04 Dampit Kabupaten malang. Pengabidan pada masyarakat ini dilakukan selama delapan bulan. Yang terlibat dalam PPM ini adalah politeknik negeri malang dan mushola RT.06 RW.04 Dampit Malang. Tujuan dari PPM ini untuk memberikan solusi dari beberapa permasalahan yang ada. Permasalahn yang ada antara lain Masih belum adanya runing text yang digunakan untuk waktu sholat, dan keterangan untuk membantu kenyamnaan saat melaksanakan ibadah sholat dan pengajian. Dan Adanya masyarakat yang belum paham tentang cara pengporasian runing text untuk mushola. Solusi yang ditawarkan tentang rencana kegiatan yang diusulkan adalah memberikan pelatihan pengoprasian perlatan yang dihibahkan berupa runing text untuk mushola.
Bimbingan Teknis Investigasi Tanah Untuk Desain Pondasi Pada Pembangunan Pengembangan TPQ Masjid Al-Ishlah di Kelurahan Dinoyo, Kecamatan Lowokwaru Kota Malang
Authors: Anggraini Novita , Sumardi  , Fadjar Purnomo  , Indah Ria Riskiyah  , Rosalia Isna Putri  
Published: December 2023

Masjid Al-Ishlah merupakan salah satu masjid yang berada di Kota Malang, tepatnya belokasi di Jl. MT. Haryono VI/834 Kelurahan Dinoyo Kecamatan Lowokwaru Kota Malang. Bangunan masjid ini terdiri dari dua lantai yaitu luas bangunan lantai satu 250 m2 dan lantai dua 200 m2. Dengan luas bangunan tersebut, Masjid Al-Ishlah dapat menampung jama’ah sholat sekitar 350 jama’ah. Masjid ini akan dibangun Taman Pendidikan Quran (TPQ) untuk anak – anak khususnya yang berada di lingkungan wilayah RW 02 Kelurahan Dinoyo. Namun, fasilitas ruang kelas dan tempat bermain di TPQ Masjid Al-Ishlah belum memadai karena TPQ ini merupakan organisasi non profit yang tidak membebankan biaya pendidikan kepada orangtua siswa. Selama ini fasilitas yang dibangun menjadi tanggung jawab masyarakat dan para donatur masjid. Untuk memenuhi kebutuhan fasilitas pendidikan agama Islam anak – anak khususnya di lingkungan wilayah RW 02 Kelurahan Dinoyo maka, warga berencana untuk melakukan pembangunan pengembangan TPQ Al-Ishlah. Dalam perencanaan pembangunan suatu infrastruktur bangunan harus dilakukan secara efektif dan efisien. Untuk mencapai hal tersebut, maka diperlukan suatu strategi berupa rencana desain. Sebagai implementasi pelaksanaan Tridharma perguruan tinggi, kegiatan PPM ini fokus pada perencanaan Penyelidikan Tanah menggunakan Sondir dan Desain Pondasi yang tahan terhadap penurunan tanah.
Pelatihan Penggunaan Google Drive untuk Pengarsipan Data Pada Ibu PKK RW 20 Kelurahan Bunulrejo
Authors: Lilies Nur Aini  , Heru Utomo  , Hiqma Nur Agustina  , Nugrahaningtyas Fatma Anyassari  , Eka Listianing Rahayu  , Ane Fany Novitasari  
Published: December 2023

Pemberdayaan dan Kesejahteraan Keluarga (PKK) RW 20 Kelurahan Bunulrejo memiliki banyak peran yang melibatkan penggunaan dokumen untuk pelaksanaan program. Selama kegiatannya, anggota PKK mengalami kesulitan untuk melakukan pengarsipan dan kesulitan memanfaatkan teknologi informasi untuk mempermudah pengarsipan. Tujuan dari kegiatan pengabdian ini untuk memberikan pelatihan penggunaan Google Drive sebagai solusi untuk mempermudah melakukan pengarsipan. Sasaran dalam pelaksanaan kegiatan ini adalah Ibu-ibu PKK RW 20 Kelurahan Bunulrejo Kota Malang. Metode yang digunakan meliputi alih pengetahuan, diskusi dan tanya jawab, serta pelatihan dan pendampingan. Berdasarkan hasil distribusi kuisoner kepuasan mayoritas peserta menyatakan puas dengan kegiatan pengabdian yang telah dilaksanakan, sebanyak 78% menyatakan puas dan sisanya 22% menyatakan tidak puas. Peserta berpendapat kegiatan pengabdian sesuai dengan kebutuhan masyarakat, pelaksanaan pengabdian mampu memberdayakan masyarakat sehingga masyarakat sanggup berkarya secara mandiri, manfaat yang diperoleh pada kegiatan pengabdian kepada masyarakat dalam kehidupan sehari-hari, pelaksanaan kegiatan membantu masyarakat untuk lebih baik kedepannya, pengarahan masyarakat dilakukan dengan baik serta sopan, kegiatan pelatihan menyenangkan dan perlu untuk diikuti.
Exploration on flexible wearable sensor motion monitoring based on novel functional polymer conjugated materials
Authors: Zhang Jie , Ding Huanxiang 
Published: December 2023

With the continuous development of flexible electronics, multi-functional device integration, artificial intelligence technology, etc., flexible wearable sensors are playing an increasingly important role in people’s daily motion monitoring. However, current flexible wearable sensors have problems such as low accuracy, poor real-time performance, and poor stability in motion monitoring, which seriously hinder the better application of flexible wearable sensors and are not conducive to the collection and monitoring of motion signals. To this end, this paper designed a flexible wearable sensor motion monitoring system and tested its performance through the preparation and performance research of new functional polymer conjugated materials. The research results show that the motion monitoring system designed based on the new functional polymer conjugated material flexible wearable sensor has good monitoring accuracy and real-time performance. When the output data is 500 pieces, the running monitoring accuracy reaches 95.4%, and the monitoring feedback time is 0.321 s; the high jump movement monitoring accuracy rate reaches 97%, and the monitoring feedback time is 0.287 s; the long jump movement monitoring accuracy rate reaches 96%, and the monitoring feedback time is 0.296 s. This shows that the flexible wearable sensor motion monitoring system of this paper has better performance and can meet the current demand for accuracy and real-time motion monitoring. This study highlights the impact of new functional polymer conjugated materials on flexible wearable sensors, helping to further solve the deficiencies of flexible wearable sensors in sports monitoring and promote their better development.
The pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome patients with co-infections
Authors: Song Huijuan , Zou Siyu , Huang Yi , Wang Yun , Wang Ting , Wei Wei , Sun Ziyong , Hou Hongyan 
Published: December 2023

ObjectiveThe study aimed to comprehensively describe and evaluate the pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) patients with co-infections.MethodsWe retrospectively collected clinical data and laboratory indicators of the SFTS patients at Tongji Hospital from October 2021 to July 2023.ResultsA total of 157 patients with SFTS virus (SFTSV) infection were involved in the analysis, including 43 co-infection and 114 non-co-infection patients. The pathogens responsible for co-infection were primarily isolated from respiratory specimens. Fungal infections, primarily Aspergillus fumigatus, were observed in 22 cases. Bacterial infections, with Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii as the main pathogens, were identified in 20 cases. SFTS patients with co-infection exhibited higher mortality (P=0.011) compared to non-co-infection patients. Among SFTS patients co-infected with both bacteria and fungi (8 cases) or specific drug-resistant strains (11 cases), the mortality rate was as high as 70% (14/19). In comparison with the non-co-infection group, SFTS patients with co-infection displayed significant alteration in inflammatory markers, coagulation function, and liver function indicators.ConclusionThe mortality rate of SFTS patients with co-infection is relatively high, underscoring the need for enhanced monitoring and timely, appropriate treatment to minimize the mortality rate.
Preventive effect and mechanism of compound Danshen dripping pills on contrast-induced nephropathy after percutaneous coronary interventional
Authors: Fu Han , Wang Linrui , Ying Shuo , Zhao Zhicheng , Zhang Peng 
Published: December 2023

BackgroundContrast-induced nephropathy (CIN) is one of the most common complications after coronary stent implantation due to the extensive development of coronary catheterization technology. Compound Danshen dripping pills (CDDP) are clinically used as cardiovascular drugs, relieving systemic inflammatory response. Previous studies have observed that CDDP can decrease CIN incidence after coronary stent implantation with uncertain effectiveness.MethodsWe conducted a prospective, randomized, single-center, single-blind, controlled trial. We enrolled patients 18 years and older with unstable angina pectoris and NSTEMI who underwent PCI at the Tianjin Chest Hospital between November 1, 2021, and November 31, 2022, and followed for 30 days. Patients were randomized to CDDP and hydration therapy (10 capsules three times/day; N = 411) or hydration only (N = 411). The primary outcome was the contrast nephropathy incidence, defined as an elevation in serum creatinine by more than 25% or 44 μmol/L from baseline within 48–72 h of contrast exposure. Secondary outcomes included major adverse cardiovascular events post-surgery and during follow-up.ResultsAfter 48 h of operation, the two groups had statistical significance in Scr and BUN values (80.0 ± 12.59 vs. 84.43 ± 13.49, P &lt; 0.05; 6.22 ± 1.01 vs. 6.40 ± 0.93, P &lt; 0.05). The difference in Scr in 72 h between the two groups was statistically significant (76.42 ± 10.92 vs. 79.06 ± 11.58, P &lt; 0.05). The CIN incidence was significantly lower in the CDDP group than in the hydration group. The CIN risk was significantly elevated in patients with LVEF &lt;50%, contrast volume ≥160 ml, and hypertension, after 48 and 72 h of operation. The serum inflammation index levels NGAL, TNF-α, oxidative stress indexes SOD, and MDA significantly differed between the two groups. However, there was no significant difference in serum apoptosis indexes Bax, Bcl-2, and Casepase-9.ConclusionsCDDP pre-treatment could prevent contrast-induced nephropathy. Inflammatory response and oxidative stress could be significant in the CDDP mechanism.
Spanish version of the Heart Failure Somatic Perception Scale (HFSPS v.3) – psychometric properties
Authors: Antonio-Oriola Rosa , Juárez-Vela Raúl , Czapla Michal , Durante Angela , Di Nitto Marco , Benavent-Cervera José Vicente , Saus-Ortega Carlos , Navas-Echazarreta Noelia , Cobos-Rincón Ana , Tejada-Garrido Clara Isabel , Santolalla-Arnedo Ivan , Gea-Caballero Vicente 
Published: December 2023

BackgroundThe Heart Failure Somatic Perception Scale (HFSPS) is an instrument that examine the existence and gravity of physical signs and symptoms in patients with heart failure, as well as early and subtle symptoms of HF that have clinical value, we aimed to translate and adapt the HFSPS from English to Spanish and evaluate the psychometric properties.MethodHFSPS translation and back translation were carried out according to the method established by of Beaton et al. A confirmatory factor analysis (CFA) was performed to test the factor structures. To assess criterion-related validity, HFSPS factor scores were correlated with Kansas City Cardiomyopathy Questionnaire (KCCQ) scores using the Spearman correlation method. The reliability of the internal consistency of the HFSPS was determined by calculating the Cronbach's alpha coefficient and the factor score determination coefficient.ResultsData from 173 patients with a mean age of 80.7 years (SD 9.1), women (51.1%), were analyzed. The majority (74.7%) were NYHA class II/III. The confirmatory factor analysis of four factors after eliminating one item showed fit indices close to the recommended indices: χ2 = 169.237, p &lt; 0.001, CFI = 0.920, TLI = 0.901, RMSEA = 0.057 and SRMR = 0.061. Regarding the validity related to the criterion, all the scores of the HFSPS dimensions were correlated with all the scores of the KCCQ dimensions and were statistically significant. The reliability of the HFSPS factors of the coefficient of determination obtained scores of 0.73 for the dyspnea factor and early and subtle and lower for edema and chest discomfort with fewer items. Cronbach's alpha was acceptable for three of the scales &gt;0.71 and poor 0.52 for chest discomfort with two items. The internal consistency index based on the model was 0.850.ConclusionThe Spanish version of the HFSPS is a valid and reliable instrument that that would be feasible to use in clinical and research setting to evaluate in the perception of symptoms in patients with heart failure.
Designing effective discussion forum in MOOCs: insights from learner perspectives
Authors: Neha  , Kim Eunyoung 
Published: December 2023

IntroductionThe study focuses on addressing the gap between the perspectives of learners and the designers of Massive Open Online Courses (MOOCs), with a particular emphasis on asynchronous discussion forums within these courses. The primary objective of this study is to bridge the gap in understanding between MOOC designers and learners regarding the organization and usability of discussion forums.MethodsIt aims to achieve this objective through a navigation experiment that investigates three main factors: (1) Classification of Discussion Forum Posts: This involves how discussion forum posts are categorized or organized. (2) Design of Different Discussion Forum Patterns: The study explores the effectiveness of various discussion forum design patterns. (3) Evaluation of Learners’ Perspective: It assesses the learners’ experiences and viewpoints regarding the discussion forums. The study identifies a gap in prior research, where the learner’s perspective has often been neglected when examining discussion forum organization and usability in MOOCs.ResultsThe results of the study indicate that the redesigned discussion forum was successful in reducing the time required by learners to navigate and explore the discussion forum. This suggests that improvements in interactive user interfaces, design elements, usability, and time efficiency can enhance the design of asynchronous discussion forums in MOOCs. The study offers recommendations and insights that MOOC designers can implement to create more effective and engaging discussion forums. These recommendations are based on the identified features and design elements that are crucial for learner satisfaction and interaction efficiency. Implementing the study’s findings by considering learner perspectives, MOOC designers can enhance the overall quality of the learning process. This includes making the learning environment more engaging for both learners and instructors.DiscussionThe study contributes to the field of online education by emphasizing the importance of learner perspectives and offering practical guidance on optimizing the design, usability, and time efficiency of discussion forums in MOOCs. In summary, this study seeks to improve the design of asynchronous discussion forums in MOOCs by focusing on the learners’ perspective, usability, and efficiency. It not only identifies key factors but also provides recommendations for MOOC designers to enhance the learning experience and engagement within these online courses.
Multiple myeloma following bone metastasis of renal cell carcinoma: a case report
Authors: Yu Hong , Zhang Shengnan , Feng Xiaohui , Gao Feng 
Published: December 2023

BackgroundThe clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis.Case summaryWe reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass. Pathology and immunohistochemistry established the diagnosis of the coexistence of myeloma with bone metastatic tumor of CCRCC in the spine. Immunotherapy and systemic chemotherapy were adopted in the clinic, and vertebral decompression was performed after anemia was corrected. This case with MM and bone metastatic tumor of CCRCC received radiotherapy and immunotherapy and acquired satisfying outcome after 1 year of follow-up.ConclusionIt is difficult to differentiate MM and bone metastatic tumor on imaging, especially when there are bone lesions at the same time, which is an easily missed diagnosis and needs to be comprehensively evaluated in combination with functional procedures, clinical laboratory tests, and histopathology.
Multi-habitat carbon stock assessments to inform nature-based solutions for coastal seascapes in arid regions
Authors: Carpenter Stephen , Evans Claire , Pittman Simon J. , Antonopoulou Marina , Bejarano Ivonne , Das Himansu S. , Möller Mona , Peel Kate , Samara Fatin , Stamoulis Kostantinos A. , Mateos-Molina Daniel 
Published: December 2023

Coastal ecosystems are integral to global carbon cycling and are increasingly recognised for their role in mitigating climate change. Within these ecosystems, the dynamics of carbon storage are diverse, varying significantly across different habitats. However, existing management strategies often focus predominantly on vegetated habitats neglecting the contributions of non-vegetated areas. We address this knowledge gap by providing a quantitative spatial assessment of carbon storage across coastal seascapes varying in plant biomass. Our comprehensive multi-habitat inventory of carbon stocks in the United Arab Emirates confirmed that mangroves are the largest carbon-storing habitat per hectare (94.3 t/ha), followed by saltmarshes (63.6 t/ha), microbial mats (51.6 t/ha), mudflats (46.8 t/ha), seagrass (32.5 t/ha), and coastal sabkha (31.0 t/ha).Mean carbon content in the top 50 cm of mangrove soils (53.9 t/ha) was similar to saltmarshes (52.7 t/ha), microbial mats (51.6 t/ha), and mudflats (46.8 t/ha). We highlight the importance of including non-vegetated habitats in carbon accounting and management strategies. Our findings suggest that a more context-specific whole-system approach is essential for guiding effective ecosystem management and designing ecologically meaningful Nature-based Solutions (NbS). Adopting this broader perspective in NbS can ensure more comprehensive conservation and restoration outcomes, which not only protect and enhance blue carbon ecosystems but also contribute to broader ecological and social benefits. This approach is pivotal for advancing our understanding of interconnected coastal ecosystems and their role in climate change mitigation.