bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Vulnerability and the Prevalence of Opioid Use Disorder Among Older Medicare Beneficiaries in U.S. Counties
Authors: Yang Tse-Chuan , Kim Seulki , Matthews Stephen A , Shoff Carla 
Published: October 2023

Abstract

Objectives
Recent research has investigated the factors associated with the prevalence of opioid use disorder (OUD) among older adults (65+), which has rapidly increased in the past decade. However, little is known about the relationship between social vulnerability and the prevalence of OUD, and even less is about whether the correlates of the prevalence of OUD vary across the social vulnerability spectrum. This study aims to fill these gaps.

Methods
We assemble a county-level data set in the contiguous United States (U.S.) by merging 2021 Medicare claims with the CDC’s social vulnerability index and other covariates. Using the total number of older beneficiaries with OUD as the dependent variable and the total number of older beneficiaries as the offset, we implement a series of nested negative binomial regression models and then analyze by social vulnerability quartiles.

Results
Higher social vulnerability is associated with higher prevalence of OUD in U.S. counties. This association cannot be fully explained by the differences in the characteristics of older Medicare beneficiaries (e.g., average age) and/or other social conditions (e.g., social capital) across counties. Moreover, the group comparison tests indicate correlates of the prevalence of OUD vary across social vulnerability quartiles in that the average number of mental disorders is positively related to OUD prevalence in the least and the most vulnerable counties and social capital benefits the less vulnerable counties.

Discussion
A perspective drawing upon contextual factors, especially social vulnerability, may be more effective in reducing OUD among older adults in U.S. counties than a one-size-fits-all approach.
Generative AI and Lexicography: The Current State of the Art Using ChatGPT
Authors: de Schryver Gilles-Maurice 
Published: October 2023

Abstract
In this article, all ten papers and talks that have been devoted to the use of ChatGPT in lexicography so far are critically analysed, their results tabulated and cross-compared, from which the leading trends are determined. Extrapolating from the trendlines, a single short but robust new prompt is fine-tuned with which articles from different word classes are generated fully-automatically for a dictionary which compares favourably to the best practice in dictionary compilation. The conclusion is that a new age, that of the successful application of generative AI in lexicography, has dawned.
In vitro activity of cefiderocol against Pseudomonas aeruginosa demonstrating evolved resistance to novel β-lactam/β-lactamase inhibitors
Authors: Shields Ryan K , Kline Ellen G , Squires Kevin M , Van Tyne Daria , Doi Yohei 
Published: October 2023

Abstract

Background
Cefiderocol demonstrates excellent activity against MDR Pseudomonas aeruginosa; however, the activity against isolates from patients previously treated with β-lactam agents is unknown. We aimed to determine the activity of cefiderocol against P. aeruginosa collected before and after treatment with traditional β-lactams and new β-lactam/β-lactamase inhibitors.

Methods
Cefiderocol MICs were determined in triplicate in iron-depleted cation-adjusted Mueller–Hinton broth and compared with β-lactam MICs tested by standard methods. All isolates underwent WGS analysis to identify mutations associated with resistance.

Results
One hundred and seventy-eight P. aeruginosa isolates were evaluated; 48% (86/178) were non-susceptible to ceftazidime/avibactam, ceftolozane/tazobactam and/or imipenem/relebactam. The cefiderocol MIC50 and MIC90 were 0.12 and 1 mg/L, respectively. Median cefiderocol MICs did not vary against isolates classified as MDR, XDR, or those non-susceptible to ceftazidime/avibactam, ceftolozane/tazobactam and/or imipenem/relebactam when compared with non-MDR isolates. Against isolates collected from patients previously treated with ceftolozane/tazobactam, cefiderocol MICs were increased 4-fold compared with baseline. Cross-resistance to cefiderocol was identified in 21% (3/14) of patients who developed treatment-emergent resistance to ceftolozane/tazobactam. Overall, 6% (11/178) of isolates demonstrated cefiderocol MICs ≥2 mg/L, which were disproportionately collected from patients previously treated with ceftolozane/tazobactam (73%; 8/11). Isolates with reduced cefiderocol susceptibility harboured mutations in ampC, tonB-dependent receptors, the response regulator pirR and ftsI.

Conclusions
Cefiderocol demonstrates excellent in vitro activity against P. aeruginosa isolates exposed to other novel β-lactam agents; however, some exceptions were identified. Cross-resistance between cefiderocol and ceftolozane/tazobactam was evident, but not with ceftazidime/avibactam or imipenem/relebactam. Reduced cefiderocol susceptibility was mediated by mutations in ampC and tonB-dependent receptors.
Endoscopic Retrograde Cholangiopancreatography Under General Anesthesia Compared to Conscious Sedation Study
Authors: Greaves Grant , Harding Kaitlyn G , Parker Brent , Nguyen Vu C , Ahmed Azim , Yee Belinda , Perren Joël , Norman Mathew , Grey Morgan , Perini Rafael , Jowhari Fahd , Bak Adrian 
Published: October 2023

Abstract

Background
Endoscopic retrograde cholangiopancreatography (ERCP) is used to diagnose and treat pancreatic and biliary disease. The current standard is to conduct ERCP under conscious sedation (CS). Patient movement and agitation during ERCP under CS can result in procedure failure and complications. Aiming to reduce procedure failure rates and complications, Kelowna General Hospital (KGH) in British Columbia, Canada transitioned to performing ERCP under general anesthesia (GA) as the practice standard.

Objective
To determine if conducting ERCP under GA compared to CS decreases procedure complications, particularly post-ERCP pancreatitis (PEP).

Methods
The charts of 2,198 patients who underwent ERCP at KGH between 2015 and 2020 were reviewed. Before September 17, 2017, ERCP was performed under CS (n = 1,316). Afterwards, ERCP was conducted under GA (n = 882). Demographic, clinical, and procedural data were extracted. The data were analyzed using univariate and multivariate statistical analysis.

Results
Procedure failure rates (CS = 9 percent, GA = 3 percent, P &lt; 0.001) decreased in the GA cohort after adjusting for age, sex, and co-morbidities. Thirty-day mortality, intensive care unit (ICU) transfer, returns post-discharge, PEP, and cholangitis rates were similar between cohorts.

Conclusion
Performing ERCP under GA compared to CS resulted in an increase in procedural success rates. Other complication rates were similar between groups.
Leading medical laboratory professionals toward change readiness: a correlational study
Authors: Waraksa-Deutsch Taryn L 
Published: October 2023

Abstract

Background
To remain effective in the dynamic health care landscape, the laboratory must embrace the continuous improvement mindset to support a culture of change, and leadership must facilitate the change process, mitigating perceived barriers of change readiness in followers.

Methods
This quantitative study was designed to determine whether there is an association between leadership style (Multifactor Leadership Questionnaire [MLQ]) and change readiness (3-component model [TCM] commitment to change/Employee Commitment Survey, and whether leadership style predicts change readiness. Laboratory professionals (n = 718) were recruited through national societies to complete a combined MLQ-TCM survey instrument. Multivariate analysis of variance, Pearson correlations, and multiple regression analyses were performed.

Results
A significant correlation between leadership style and change readiness (transformational leadership [TL] and affective commitment to change, r(716) = .12, P = .002; passive-avoidant behavior and continuance commitment to change, r(716) = .25, P &lt; .001) and between leadership style and leadership outcomes (TL and effectiveness, r(716) = .90, P &lt; .001) was identified. Transformational leadership was a significant predictor of change readiness (β = .17, P &lt; .05).

Conclusion
It is recommended that laboratory leaders use transformational leadership or situational leadership to improve followers’ affective commitment to change and reduce followers’ continuance commitment to change, thus improving commitment to continuous improvement. Leaders should also limit passive-avoidant behavior.
Discovery of an extremely intermittent periodic radio source
Authors: Surnis M P , Rajwade K M , Stappers B W , Younes G , Bezuidenhout M C , Caleb M , Driessen L N , Jankowski F , Malenta M , Morello V , Sanidas S , Barr E , Kramer M , Fender R , Woudt P 
Published: October 2023

ABSTRACT
We report the serendipitous discovery of an extremely intermittent radio pulsar, PSR J1710−3452, with a relatively long spin period of 10.4 s. The object was discovered through the detection of 97 bright radio pulses in only one out of 66 epochs of observations spanning almost three years. The bright pulses have allowed the source to be localized to a precision of 0.5 arcsec through radio imaging. We observed the source location with the Swift X-ray telescope but did not detect any significant X-ray emission. We did not identify any high-energy bursts or multifrequency counterparts for this object. The solitary epoch of detection hinders the calculation of the surface magnetic field strength, but the long period and the microstructure in the single-pulses resembles the emission of radio-loud magnetars. If this is indeed a magnetar, it is located at a relatively high Galactic latitude (2.9°), making it potentially one of the oldest and the most intermittent magnetars known in the Galaxy. The very short activity window of this object is unique and may point towards a yet undetected population of long period, highly transient radio emitting neutron stars.
Role of hypofractionated stereotactic radiotherapy for primary optic nerve sheath meningioma
Authors: Koç İrem , Yüce Sarı Sezin , Yazıcı Gözde , Kapucu Yasemin , Kıratlı Hayyam , Zorlu Faruk 
Published: October 2023

Abstract

Background
Optic nerve sheath meningiomas (ONSM) are rare tumors potentially causing visual deficits. This study aims to report the anatomic and visual outcomes of patients with primary ONSM treated with hypofractionated stereotactic radiotherapy (HF-SRT).

Methods
Data of 36 patients treated with HF-SRT between 2008 and 2019 were retrospectively collected. The clinical target volume (CTV) was equal to the gross tumor volume and a 2 mm was added for the planning target volume. All responses other than progression were accepted as local control (LC). The VA grading was performed under 3 groups to provide an even distribution; 20/400 or worse, 20/40-20/400, and 20/40 or better.

Results
Median HF-SRT dose was 25 Gy and the median CTV was 1.94 cc. After a median of 106 months of follow-up, the tumor regressed in 23 (64%), was stable in 9 (25%), and progressed in 4 (11%) eyes. The overall rate of LC was 89% with 2-, 5-, 10-, and 15-year rate of 100%, 94%, 84%, and 84%, respectively. Treatment-related late toxicity rate was 11%. The VA was stable in 27 (75%) eyes, improved in 5 (14%) eyes, and worsened in 4 (11%) eyes, respectively, after HF-SRT. Female gender was the only independent predictor of an improved VA.

Conclusions
Hypofractionated stereotactic radiotherapy is a safe and satisfactory treatment option for primary ONSM without severe toxicity. It may be advisable to commence treatment before an established visual deficit of 20/400 or worse occurs, to make the most of the functional benefit.
The unusual suspects: are well-meaning environmental stakeholders and institutions undercutting the contributions that companies can make to fighting climate change?
Authors: Ballentine Roger S 
Published: October 2023

Abstract
There is broad consensus that a significant majority of the capital needed to fund a low carbon transition consistent with science-based decarbonization timelines will have to come from the private sector. While still inadequate, the past decade-plus has seen a nonlinear increase in corporate capital spend in pursuit of voluntary climate goals. In the absence of significant regulatory mandates or meaningful carbon pricing, how this ‘corporate climate spend’ is directed is influenced—if not largely directed—by an array of emissions accounting rules, third-party defined leadership metrics and methodologies. This ‘rules and reward ecosystem’ is largely the design of environmental advocates, academics, and other aligned stakeholders and philanthropists. Sitting at the heart of this ecosystem is the Greenhouse Gas Protocol—a purported accounting framework that underpins how companies can undertake climate-based interventions and record progress. Launched by environmental stakeholders in 1998, the Protocol has since become the de facto rulebook used by highly influential third-party corporate leadership and target setting organizations, sustainability rating and evaluation entities serving the investment community, and is being incorporated into emerging mandatory corporate disclosure programs. Ironically, given its architects, today the rules and reward ecosystem results in significant mis-allocations and constraints on corporate climate spend and is reducing the potential climate change-mitigating impact of crucial private capital. This paper explores the flaws in incumbent greenhouse gas accounting and leadership program rules and proposes pathways for change that would better optimize the flow of private capital available and needed to address the climate crisis.
FLASHING: Project overview
Authors: Imai Hiroshi , Hamae Yuhki , Amada Kei , Nakashima Keisuke , Shum Ka-Yiu , Kasai Rina , Gómez José F , Uscanga Lucero , Tafoya Daniel , Orosz Gabor , Burns Ross A 
Published: October 2023

Abstract
This paper describes an overview of the FLASHING (Finest Legacy Acquisitions of SiO-/H2O-maser Ignitions by the Nobeyama Generation) project promoted using the 45 m telescope of Nobeyama Radio Observatory, which aims to intensively monitor H2O (at 22 GHz) and SiO (at 43 GHz) masers associated with so-called “water fountain” sources. Here we show scientific results based on the data taken in the first five seasons of FLASHING, from 2018 December to 2023 April. We show the evolution of the H2O maser spectra, discovering new spectral components that break the record of the jet’s top speed and/or systematic velocity drifts in the spectrum indicating acceleration or deceleration of the maser gas clumps. For the 43 GHz SiO maser emission, we newly detect it in one source and find that it is no longer present in another source. This implies that the jets from these water fountains can be accelerated or decelerated, and show how circumstellar envelopes are destroyed.
Socioeconomic vulnerability and differential impact of severe weather-induced power outages
Authors: Ganz Scott C , Duan Chenghao , Ji Chuanyi 
Published: October 2023

Abstract
In response to concerns about increasingly intense Atlantic hurricanes, new federal climate and environmental justice policies aim to mitigate the unequal impact of environmental disasters on economically and socially vulnerable communities. Recent research emphasizes that standard procedures for restoring power following extreme weather could be one significant contributor to these divergent outcomes. Our paper evaluates the hypothesis that more economically and socially vulnerable communities experience longer-duration power outages following hurricanes than less vulnerable communities do, conditional on the severity of the impact of the storm itself. Using data from eight major Atlantic hurricanes that made landfall between January 2017 and October 2020 and induced power outages for over 15 million customers in 588 counties in the Southeast, we demonstrate a significant relationship between socioeconomic vulnerability and the duration of time that elapses before power is restored for 95% of customers in a county. Specifically, a one-decile change in the socioeconomic status theme in the Social Vulnerability Index, a measure of vulnerability produced by the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry, produces a 6.1% change in expected outage duration in a focal county. This is equivalent to a 170-min average change in the period of time prior to power restoration.
Ocean emission of microplastic
Authors: Shaw Daniel B , Li Qi , Nunes Janine K , Deike Luc 
Published: October 2023

Abstract
Microplastics are globally ubiquitous in marine environments, and their concentration is expected to continue rising at significant rates as a result of human activity. They present a major ecological problem with well-documented environmental harm. Sea spray from bubble bursting can transport salt and biological material from the ocean into the atmosphere, and there is a need to quantify the amount of microplastic that can be emitted from the ocean by this mechanism. We present a mechanistic study of bursting bubbles transporting microplastics. We demonstrate and quantify that jet drops are efficient at emitting microplastics up to 280μm in diameter and are thus expected to dominate the emitted mass of microplastic. The results are integrated to provide a global microplastic emission model which depends on bubble scavenging and bursting physics; local wind and sea state; and oceanic microplastic concentration. We test multiple possible microplastic concentration maps to find annual emissions ranging from 0.02 to 7.4—with a best guess of 0.1—mega metric tons per year and demonstrate that while we significantly reduce the uncertainty associated with the bursting physics, the limited knowledge and measurements on the mass concentration and size distribution of microplastic at the ocean surface leaves large uncertainties on the amount of microplastic ejected.
Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration
Authors: Shahin Saba , Tan Patrick , Chetsawang Jason , Lu Bin , Svendsen Soshana , Ramirez Stephany , Conniff Trevor , Alfaro Jorge S , Fernandez Michael , Fulton Aaron , Laperle Alexander H , Svendsen Clive N , Wang Shaomei 
Published: October 2023

Abstract
Stem cell therapy for retinal degenerative diseases has been extensively tested in preclinical and clinical studies. However, preclinical studies performed in animal models at the early stage of disease do not optimally translate to patients that present to the clinic at a later stage of disease. As the retina degenerates, inflammation and oxidative stress increase and trophic factor support declines. Testing stem cell therapies in animal models at a clinically relevant stage is critical for translation to the clinic. Human neural progenitor cells (hNPC) and hNPC engineered to stably express GDNF (hNPCGDNF) were subretinally injected into the Royal College of Surgeon (RCS) rats, a well-established model for retinal degeneration, at early and later stages of the disease. hNPCGDNF treatment at the early stage of retinal degeneration provided enhanced visual function compared to hNPC alone. Treatment with both cell types resulted in preserved retinal morphology compared to controls. hNPCGDNF treatment led to significantly broader photoreceptor protection than hNPC treatment at both early and later times of intervention. The phagocytic role of hNPC appears to support RPE cell functions and the secreted GDNF offers neuroprotection and enables the extended survival of photoreceptor cells in transplanted animal eyes. Donor cells in the RCS rat retina survived with only limited proliferation, and hNPCGDNF produced GDNF in vivo. Cell treatment led to significant changes in various pathways related to cell survival, antioxidative stress, phagocytosis, and autophagy. A combined stem cell and trophic factor therapy holds great promise for treating retinal degenerative diseases including retinitis pigmentosa and age-related macular degeneration.
Physiological and phenological adjustments in water and carbon fluxes of Aleppo pine forests under contrasting climates in the Eastern Mediterranean
Authors: Markos Nikos , Preisler Yakir , Radoglou Kalliopi , Rotenberg Eyal , Yakir Dan 
Published: October 2023

Abstract
The ability of plants to adjust to the adverse effects of climate change is important for their survival and for their contribution to the global carbon cycle. This is particularly true in the Mediterranean region, which is among the regions that are most vulnerable to climate change. Here, we carried out a 2-year comparative ecophysiological study of ecosystem function in two similar Eastern Mediterranean forests of the same tree species (Pinus halepensis Mill.) under mild (Sani, Greece) and extreme (Yatir, Israel) climatic conditions. The partial effects of key environmental variables, including radiation, vapor pressure deficit, air temperature and soil moisture (Rg, D, T and soil water content (SWC), respectively), on the ecosystems’ CO2 and water vapor fluxes were estimated using generalized additive models (GAMs). The results showed a large adjustment between sites in the seasonal patterns of both carbon and water fluxes and in the time and duration of the optimal period (defined here as the time when fluxes were within 85% of the seasonal maximum). The GAM analysis indicated that the main factor influencing the seasonal patterns was SWC, while T and D had significant but milder effects. During the respective optimal periods, the two ecosystems showed strong similarities in the fluxes’ responses to the measured environmental variables, indicating similarity in their underlying physiological characteristics. The results indicate that Aleppo pine forests have a strong phenotypic adjustment potential to cope with increasing environmental stresses. This, in turn, will help their survival and their continued contribution to the terrestrial carbon sink in the face of climate change in this region.