bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXPERIMENTAL RATIONALE FOR THE APPLICATION OF BIORESORBABLE PERSONALIZED COLLAGEN MEMBRANES FOR CLOSURE OF DEFECTS IN THE ORAL MUCOSA
Authors: Gostev Mikhail , Tarasenko Svetlana , Kazumyan Sabina , Diachkova Ekaterina , Usanova Anna , Fayzullin Alexey , Timashev Petr , Sadchkova Elena 
Published: February 2024

Subject. The subject of the study is the biomechanical properties of a personalized collagen membrane in the area of wound defects of the oral mucosa.
Objectives. To increase the effectiveness of treatment of patients with extensive surgical wound defects of the oral mucosa by experimentally substantiating the use of developed collagen membranes from bovine Achilles tendon.
Methodology. Based on the Central Vivarium of the First Moscow State Medical University named after I.M. Sechenov (Sechenov University) conducted an experimental study on laboratory animals (rabbits) (n = 12) to create a wound surface in the oral cavity (limited vestibuloplasty according to Clark on the upper jaw) and its closure with collagen membranes with an assessment of the course of the postoperative period and subsequent histological examination of biomaterials: 1st – using a personalized collagen membrane, 2nd – using a collagen membrane with lactoferrin, 3rd – using a Mucograft membrane, 4th group – control.
Results. In the postoperative period, on the 3rd day, moderate swelling, and hyperemia in the area of vestibuloplasty were noted in the oral cavity of rabbits: the least pronounced swelling was in animals in the 2nd group of operations (1.5 ± 0.5 points) (p = 0.001), hyperemia – in the 3rd group (1.7 ± 0.4 points) (p = 0.001). On the 5th day in the oral cavity of experimental animals, hyperemia of the mucous membrane of the oral vestibule in the 2nd group was 0.8 ± 0.4 points (p = 0.001), and in the 3rd group – 1.8 ± 0.4 points (p = 0.001). According to the histological research method, a significant difference was noted in the quantity and quality of the formed soft tissues in the area of application of collagen matrices compared to healing by secondary intention (p < 0.05). The results of histological examination showed in group 2 epithelization with acanthosis and proliferation of the basal layer.
Conclusion. The effectiveness of the developed collagen membranes from the Achilles tendon has been proven in eliminating extensive wound defects of the oral mucosa.
The Human Right to an Environment Safe for Life and Health: Legal Regulation, Contemporary Challenges and Comparative Perspectives
Authors: Leheza Yevhen , Sinkevych Olena , Kravtsova Zorina , Kudriavtseva Olena , Cherniak Ievgeniia 
Published: February 2024

Abstract: The purpose of the research is to disclose human rights to an environment safe for life and health. Main content. The article reveals relationship between the concepts of “human rights” and "citizen’s rights” in the environmental sphere, “ecological rights”, “ecological responsibilities” and “the human right to an environment safe for life and health”. The war initiated by Russia caused significant damage to the environment, social and industrial infrastructure, flora and fauna. Methodology: The methodological basis of the research is the dialectical method of scientific knowledge, through the application of this method considered were legal, functional, organizational and procedural aspects of the essence of human rights to an environment safe for life and health. Conclusions. The legal grounds for the allocation of ecological rights to a separate institution in the system of constitutional rights are singled out, and their definition is derived. It was emphasized that Ukrainian citizens and non-governmental organizations made a lot of efforts to document the damages. In particular, EcoAction and Environment People Law organizations collect and publish relevant data on an ongoing basis. Thus, the "EcoZagroza" platform regularly publishes estimates of damages caused by environmental crimes, these estimates are calculated by the State Environmental Inspectorate of Ukraine.
Key words: human right, constitutional law, environmental conservation, environmental legislation, law.
Development of a prototype of a theranostic system based on silica nanoparticles with immobilized fluorescent dyes and VEGF targeting ligand.
Authors: Cheburkin Yu. V. , Shulmeister G. A. , Bondarenko A. B. , Chistyakova A. V. , Korolev D. V. 
Published: February 2024

Background. Administration of certain drugs causes undesirable effects associated with the systemic effect of the active substance on the entire body. Selective targeting of the drug to the affected tissue promotes a selective increase in the concentration of the substance in the area of interest, thereby reducing the systemic effect and enhancing the local therapeutic effect.Objective. Development of a targeted delivery system for theranostic agents using recombinant human vascular endothelial growth factor type A (rhVEGF-A121) as a targeting ligand.Design and method. To create the theranostic complex, commercially available reagents were used: the recombinant protein rhVEGF-A121 (cat.#: PSG140-10, LLC CyStorLab, Skolkovo, Russia) and fumed silica Aerosil (A-200, Degussa AG, Germany). The tosyl spacer that interconnects both components was synthesized in the laboratory. Protein conjugation with fluorophores was also carried out in-house. Indocyanine green (ICG; Sigma-Aldrich, USA) and rhodamine B (JSC Lenreaktiv, St. Petersburg, Russia) were taken for immobilization.Results. In the course of the work, functionalization of silica nanoparticles (SiNPs) with a tosyl spacer was carried out, conjugates of SiNPs with rhVEGF-A121 were synthesized, and theranostic constructs based on SiNPs were obtained, including rhVEGF-A121 as a targeting ligand, and ICG/Rhodamine B as a visualizing label.Conclusion. In the presented study, a prototype of a complex for targeted delivery of a theranostic agent to tissues with an active angiogenesis process, for example, to tumor and ischemic tissues, was developed. To solve the problem, we immobilized on the surface of SiNP a recombinant protein of human vascular endothelial growth factor (rhVEGF) to use as a guide ligand. Such a synthetic construct will help to deliver diagnostic and/ or medicinal substances packed in SiNP directly to cells that overexpress extracellular specific receptors of the VEGFR family. In subsequent in vivo experiments, delivery efficiency will be assessed by tissue accumulation of the fluorophores ICG and rhodamine B, which have been conjugated to the targeting ligand protein. The physicochemical characteristics of the obtained samples were studied by the methods of spectrophotometry and dynamic light scattering.
Penggunaan Media Sosial Sebagai Media Kampanye Dalam Penyelenggaraan Pemilihan Umum dan Pemilihan Kepala Daerah
Authors: Munfida Nuris Sabilatul , Soetijono Iwan Rachmad , Indrayati Rosita 
Published: February 2024

AbstrakPemilihan umum dan pemilihan kepala daerah merupakan wadah untuk mempresentasikan keinginan rakyat dalam memilih wakilnya di lembaga pemerintahan, termasuk didalamnya adalah proses kampanye sebagai wadah untuk meraup dukungan dari masyarakat. Ketersediaan media sosial di era kemajuan teknologi informasi menyediakan banyak alternatif metode kampanye bagi para peserta, salah satunya dengan berkampanye melalui media sosial. Media sosial merupakan seperangkat alat komunikasi dan kolaborasi baru yang menciptakan terjadinya jenis interaksi dengan memudahkan penggunanya untuk dapat berpartisipasi, berbagi dan menuangkan isi, termasuk untuk berkampanye. Pemanfaatan media sosial sebagai media kampanye tentunya memberikan dampak negatif dan postif. Dampak positifnya adalah selain lebih efisien dalam hal biaya juga pesan atau visi misi pasangan calon dapat cepat mudah tersampaikan kepada khalayak. Sedangkan dampak negatif yang dapat terjadi adalah penyalahgunaan media sosial sebagai alat melakukan kampanye hitam.Kata kunci : Kampanye; Media soial; Pemilu; Pilkada.

AbstractGeneral elections and regional head elections are a forum for presenting the people's wishes in electing their representatives in government institutions, including the campaign process as a forum for gaining support from the community. The availability of social media in the era of advances in information technology provides many alternative campaign methods for participants, one of which is campaigning via social media. Social media is a new set of communication and collaboration tools that create types of interaction by making it easier for users to participate, share and share content, including campaigning. The use of social media as a campaign medium certainly has negative and positive impacts. The positive impact is that apart from being more efficient in terms of costs, the message or vision and mission of the candidate pairs can be quickly and easily conveyed to the public. Meanwhile, the negative impact that can occur is the misuse of social media as a tool for carrying out black campaigns.Keywords: Campaign, social media; General elections; Regional head elections.
Productivity Decline due to Fines Migration Associated with High Water Cuts
Authors: Russell T. , Nguyen C. , Loi G. , Mohd Shafian S. R. , Zulkifli N. N. , Chee S. C. , Razali N. , Zeinijahromi A. , Bedrikovetsky P. 
Published: February 2024

Summary
The objective of this work is to describe the extent of productivity decline due to fines migration during periods of increasing water-cut. Two models are presented which allow for estimating the formation damage due to fines migration in both homogeneous and heterogeneous reservoirs.
The model utilizes a description of the fluid distributions withing the pore structure to determine the fines detachment during progressive sweep of the reservoir by an aquifer. In heterogeneous reservoirs, an extension of the Dietz model is used to calculate pseudo relative permeability curves accounting for any arbitrary permeability distribution in a layer-cake reservoir. Both models are compared with field productivity decline data to evaluate their validity.
Both models allow for explicit predictions of the wellbore productivity during periods of increasing water-cut. A novel diagnostic plot, the well impedance plotted against the well fractional flow, allows for the isolation of the formation damage characteristics of the reservoir. Tuning the formation damage and reservoir properties using field data exhibits good agreement and allows for extrapolation of the curves to higher water cuts. The models provide unique insight into the future formation damage of the well and allow for strategic planning of well remediation and stimulation. For heterogeneous reservoirs, the new diagnostic plots are proven to be linear, regardless of the permeability distribution in the reservoir, providing a quick and easy tool for formation damage evaluation.
The new models and diagnostic plot provide a simple method to extrapolate existing formation damage and estimate formation damage from laboratory studies and/or well analogues.
Experimental Characterization of Linear Swelling of Reactive Clays Dominated Wells: Comparison of Drilling Fluid Systems
Authors: Konate Nabe , Salehi Saeed , Mokhtari Mehdi , Ghalambor Ali 
Published: February 2024

Abstract
Shale drilling remains one of the oil industry's most challenging and expensive operations. One of the main concerns in shale drilling is the instability of the wellbore, which can be attributed to the physio-chemical interaction between the drilling fluid systems and the shale formation. This poor interaction is primarily caused by the presence of high-reactive clays, which are known to cause swelling and dispersion issues during drilling. This paper evaluates the linear swelling characteristics of a shale formation dominated by high-reactive clay. A comparative analysis of various drilling fluids’ performance in controlling shale swelling is performed for four (4) clay-dominated wells drilled in the Tuscaloosa Marine Shale (TMS). The mineralogy concentration of samples obtained from different wells drilled in the shale formations is characterized using Fourier-transform infrared spectroscopy (FTIR). Additionally, clay swelling tests are performed in accordance with the American Society of Material Testing (ASTM) Standard Section D5890 to determine the swelling indices of the wells under investigation when exposed to different drilling fluid systems. The study reveals that all the wells tested have a clay concentration of at least 50%. Furthermore, the choice of drilling fluid systems significantly affects the swelling rate. High-performance water-based mud (HPWBM) systems, such as KCl and high salinity formate brine, exhibit improved swelling inhibition and compatibility with high-reactive shale formations. The study revealed that the use of high-performance water-based systems reduces the swelling tendency of clay by as much as 60% compared to conventional water-based systems. The use of inhibitive mud systems also minimized the size of the opening of the tetrahedral sheet of the clay during water invasion as opposed to the conventional water-based mud systems.
How High-Resolution Visualisations and Quantifications Gave Insight into Damaging Mechanisms and Treatment Fluid Performance in Omani Carbonate Reservoirs
Authors: Green J. , Patey I. , Wright L. , Zonjee P. , Al Hosni S. , Al Mamari O. 
Published: February 2024

Abstract
A study was carried out to examine Formation Damage mechanisms caused by drilling and completion fluids in onshore wells in Oman. A specific understanding of what caused any damage was important, as this data would be used to help select treatment fluid options and assess their suitability. Two phases of corefloods looked at the compatibility of drilling mud and displacement fluid with reservoir core, and two further phases considered a range of treatment options. Treatment fluids included different strengths of hydrochloric acid, with and without solvent. The initial phases showed moderate to very high levels of permeability reduction, predominantly caused by the nature of the drilling mud-cakes and incomplete clean-up during drawdown. 15% HCl was successful in removing much of the operational fluid damage but was typically not forming wormholes. Including a solvent seemed to aid in wormhole development but left some of the operational fluid damage at the wellbore. Using only traditional metrics such as permeability measurement, filtrate loss volumes, and electron microscopy, it was difficult to see differences between the treatment options; when adding in the visualisations and quantifications there were clear variances in behaviour. Taking this integrated approach was therefore key to gaining a proper understanding of damaging mechanisms, how they could be removed or bypassed, and whether treatment fluids worked as intended.
The Value of Underbalanced Coiled Tubing Drilling UBCTD in Unconventional Mature Fields: Decision Analytic Approach
Authors: Al-Sharea Maher. Falih. 
Published: February 2024

Abstract
Under-balanced Coiled Tubing Drilling (UBCTD) is a promising method for the redevelopment of unconventional mature reservoirs through re-entries. Yet, such projects have unique technical, geological and economic challenges. Thus, the commercial value is not fully realized. In this paper, we discuss an appraisal method that consider the best number of re-entries subject to technical, geological and economic uncertainties.
The methodology involves three main components: 1. Reviewing key papers to assess the primary benefits of underbalanced drilling, and identifying uncertainties related to its applications. 2. Evaluating the appropriateness of coiled tubing drilling for underbalanced applications, including the associated costs. 3. Developing a decision-analytic framework to facilitate sound decision-making regarding the optimal number of re-entries. Our valuation method is based on describing uncertain factors, both technical and economical, and using them in a consistent valuation framework to support analysis and decision-making. The valuation framework also reveals the economic threshold for drilling wells, generating general managerial decision insights.
Through this method, we show that technical and market factors influence the decision to use this technology in the development of unconventional mature fields. In this context, determining the number of re-entries is contingent upon the economic threshold, which, in turn, is influenced by market uncertainties. This necessitates employing consistent models to estimate the level of confidence for future oil prices.
The proposed workflow provides consistent modeling of the key uncertain factors in a straightforward decision-making framework.
Long-term Coreflood Testing with Biopolymers—A Laboratory Investigation Showing How Return Permeability Improves From 0 to 100 Percent by Getting a Critical Parameter Right
Authors: Howard S. , TX Montogomery, 
Published: February 2024

Abstract
A series of long-term coreflood tests has shown the importance of considering the self-breaking rate of biopolymers when designing coreflood tests of low-solids and solids-free brine-based drilling and completion fluids that naturally contaminate the core plug with biopolymers during testing.
The tests were conducted with a solids-free potassium formate brine–based reservoir drilling fluid, formulated with xanthan gum and starch, which when exposed to overbalanced pressure, invaded deep into the core plug. The coreflood test simulated filtrate invasion into a water-saturated formation while drilling an injection well. In this scenario the core plug was initially 100% saturated with formation water, and return permeability was measured by injecting formation water through the core in the same direction as the test fluid filtrate invasion.
Testing was conducted at two temperatures, 121 and 149°C (250 and 300°F). At both test temperatures there was a very good correlation between the cleanup or permeability recovery rate of the core plug and the biopolymer self-breaking rates, which had been measured in an earlier study. Due to the low cleanup rate at the lowest temperature, this test was terminated as soon as the cleanup rate was fully established, and the testing was continued at the higher temperature until the permeability had reached close to 100% of its initial value.
The initial 49-hours cleanup with formation water at 121°C (250°F) resulted in a return permeability to formation water of only 3.8%, explaining why laboratory coreflood tests with low-solids/solids-free brine-based drilling and completion fluids containing biopolymeric additives are generally unable to reproduce or predict the excellent well performance the same fluids deliver in the field after days, weeks, or months of steady clean-up.
The results also give us useful insights into what to expect when such fluids are used to drill injection wells. Although the biopolymer self-breaking rate is much higher in the low-salinity injection water, it takes time for biopolymers to break down enough in the protective ionic environment of the formate brine for the filtrate to be diluted and displaced locally by the flow of injection water.
The desire to reduce fluid screening and qualification costs unfortunately often means that reservoir drilling and completion fluid selection decisions are based on the results of short-term coreflood tests. This may be the correct procedure for fluids that cause permanent intractable damage from solids plugging. However, for solids-free or low-solids fluids containing self-breaking biopolymers, relying on such short-term tests can mean that the wrong fluid selection decisions are made.
Nanofluids as a Promising Solution for Stabilizing Asphaltenes and Improving Oil Recovery in Mature Fields
Authors: Cardenas J. C. , Jaimes M. G , Castillo R. , Dorado R. , Patiño J. C. , Prada A. , Galvis H. , Conde O. R. 
Published: February 2024

Abstract
The objectives of this study are to investigate the potential of nanofluids in stabilizing asphaltenes and enhancing oil recovery in mature fields. The research involves evaluating nanofluid colloid stability, characterizing formation fluid properties, assessing nanofluid-crude oil interaction, and examining its interaction with the rock matrix. By addressing these objectives, we contribute to understanding the practical application of nanofluids in mitigating asphaltene challenges and improving oil production in mature fields.
The overall approach of this study involves conducting a series of experimental evaluations. The colloid stability of the nanofluid is tested to ensure its effectiveness in inhibiting asphaltenes. Formation fluids are characterized using techniques such as the Advanced Solid Content Instrument (ASCI), Oliensis analysis, rheology measurements, percentage of basic sediment and water (%BS&W) analysis, and physicochemical analysis of the formation water. Fluid-fluid evaluation is performed to assess the interaction between the nanofluid and the crude oil. Rock-fluid evaluation is conducted to examine the alteration of wettability and its impact on oil recovery.
The experimental evaluation of the nanofluid yielded significant findings. The nanofluid exhibited exceptional colloid stability, effectively inhibiting asphaltenes with an impressive 18.0% inhibition rate. Notably, the interaction between the nanofluid and the crude oil induced wettability alterations, resulting in a remarkable 31.5% increase in the recovery factor compared to the damaged porous medium condition. These results highlight the promising potential of nanofluids for stabilizing asphaltenes and enhancing oil recovery in mature fields. The findings from this study contribute valuable insights into the practical application of nanotechnology within the petroleum industry, paving the way for improved strategies and solutions to overcome asphaltene-related challenges in oil production processes.
This study explores the novel application of nanofluids for stabilizing asphaltenes in oil production. It emphasizes the unique properties of nanoparticles, including their high surface area-to-mass ratio and magnetic properties, enabling effective adsorption and inhibition mechanisms. The research also demonstrates wettability alterations and the formation of a repulsive force between crude oil particles and reservoir rock, impacting oil recovery.
Stimulation of M2 Macrophage Polarization and Presentation of Tumor Antigens by Hybrid Hydrogel Based on Lysate of M1 Macrophages and Tumor Cells for Activation of Anti-Tumor Immunotherapy
Authors: Yingli Luo , Chen Haha , Yu Xiaoming 
Published: February 2024

Abstract
Tumor therapy remains a major challenge in modern medicine. In recent years, autologous cell-derived hydrogels have gained significant attention as an innovative treatment strategy and have been extensively investigated for their potential applications in tumor immunotherapy. They not only directly interact with cells but also provide an ideal scaffold structure, facilitating the restoration of tumor tissue to a normal state. Moreover, hydrogels demonstrate excellent drug loading capacity for targeted delivery of anti-tumor drugs, thereby enhancing therapeutic efficacy. As they are derived from the patient's own cells, immunological rejection and safety concerns associated with exogenous materials can be avoided. Here, we prepared the hybrid hydrogel with the combination of tumor cells lysate and M1 macrophages lysate. The M1 macrophages lysate polarized the M2 macrophages, otherwise, the induced M1 macrophages could uptake the tumor antigens from the prepared hybrid hydrogel. Then, they will present the tumor antigens and stimulate the naïve T cells. The activated T cells will specifically kill the tumors. Therefore, the platform of autologous hybrid cells lysate will be helpful for the tumor immunotherapy.