bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of the 2019 ACR/EULAR Classification Criteria for IgG4-Related Disease in a Large Chinese Cohort
Authors: An Zhuo-Yu , Fu Jiang-Nan , Zeng Qiao-Zhu , Zhufeng Yun-Zhi , Ning Xiao-Ran , Li Hui-Juan , Ma Xiang-Bo , Wang Kun-Kun , Bian Wen-Jie , Zhang Yu-Xin , Li Zhan-Guo , Liu Yan-Ying 
Published: January 2024

Objective
The purpose of this research was to ascertain the effectiveness of the newly established criteria for classifying IgG4-related disease (IgG4-RD), as applied to a large Chinese cohort in real-world clinical settings.

Methods
Patient data were procured from the digital health records of 4 prominent academic hospitals. The criterion standard for identifying IgG4-RD patients was from a seasoned rheumatologist. The control group consisted of individuals with other ailments such as cancer, other forms of pancreatitis, infectious diseases, and illnesses that mimic IgG4-RD.

Results
A total of 605 IgG4-RD patients and 760 mimickers were available for analysis. The 2019 EULAR/ACR criteria have a sensitivity of 69.1% and a specificity of 90.9% in this large Chinese cohort. IgG4-RD had a greater proportion of males (55.89% vs 36.25%, p < 0.001), an older average age at diagnosis (54.91 ± 13.44 vs 48.91 ± 15.71, p < 0.001), more pancreatic (29.59% vs 6.12%, p < 0.001) and salivary gland (63.30% vs 27.50%, p < 0.001) involvement, and a larger number of organ involvement (3.431 ± 2.054 vs 2.062 ± 1.748, p < 0.001) compared with mimickers.

Conclusions
The 2019 EULAR/ACR criteria are effective in classifying IgG4-RD in Chinese patients, demonstrating high specificity and moderate sensitivity.
SPECT/CT for Early Detection of Stress Reactions After Reverse Shoulder Arthroplasty
Authors: Park Jong Hun , Kim Hyun Gon , Kim Jae Soo , Kim Su Cheol , Yoo Jae Chul 
Published: January 2024

Abstract
The altered biomechanics after reverse shoulder arthroplasty, combined with the accumulation of various stress risers, can lead to stress fractures (SFs) around the prosthesis. The incidence of stress reactions (SRs) after reverse shoulder arthroplasty, characterized by pain and tenderness without radiographic or CT evidence of fractures, is approximately 4.2%, which is comparable to the incidence of SF (6.4%). Among patients with SR, a substantial 32% eventually progress to fractures during clinical follow-up. SPECT/CT is a promising tool that combines morphologic and metabolic information for assessing mechanical bone stress. Therefore, early detection of SR through SPECT/CT can help prevent SF.
Incidental Prostate-Specific Membrane Antigen–Avid Vestibular Schwannoma Detected on 68Ga–Prostate-Specific Membrane Antigen PET/CT
Authors: Chen Jeffrey , Bui Paul , Bui Chuong , Mansberg Robert 
Published: January 2024

Abstract
A 62-year-old man was referred for a 68Ga–prostate-specific membrane antigen (PSMA) PET/CT scan for newly diagnosed prostate cancer (ISUP grade 5), on the background of left vestibular schwannoma treated with surgical excision 25 years ago. PSMA PET study confirmed the presence of PSMA-avid malignancy in the left prostate lobe with no evidence of PSMA-avid nodal or distant metastasis. An incidental PSMA-avid focus (SUVmax, 4.3) was identified in the region of the left cerebellopontine angle, which corresponded to a homogeneous enhancing lesion centered at the left internal acoustic canal and left cerebellopontine angle on MRI. The combined PSMA PET findings and MRI characteristics were consistent with recurrent vestibular schwannoma.
FAPI PET Missed Widespread Bone Marrow Metastases From Follicular Thyroid Cancer That Were Detected by FDG PET
Authors: Shi Xuan , Lan Wei , Bin Ji 
Published: January 2024

Abstract
A 62-year-old woman with follicular thyroid cancer who had received total thyroidectomy and multiple rounds of radioactive iodine therapy underwent both 18F-FDG and 18F-FAPI PET/CT. 18F-FAPI PET failed to reveal widespread bone marrow metastases that were clear visualized on 18F-FDG PET. This case highlights that FAPI PET may not be used to describe bone metastases in detail in follicular thyroid cancer patients, as it is not a sensitive method to detect bone marrow metastases.
Hypermetabolic Axillary Lymphadenopathy After Shingrix Vaccination for Varicella Zoster Virus
Authors: Eshet Yael , Eifer Michal , Domachevsky Liran , Tau Noam 
Published: January 2024

Abstract
A 67-year-old woman underwent staging 18F-FDG PET/CT scan for recently diagnosed breast cancer. Her scan showed a highly hypermetabolic right breast mass, with ipsilateral hypermetabolic axillary lymph nodes. The contralateral axillary lymph nodes were also enlarged with avid FDG uptake, alongside focal increased uptake in the left deltoid muscle. Upon investigation, the patient reported receiving the new zoster recombinant adjuvanted varicella zoster vaccine (Shingrix, GlaxoSmithKline) 4 days before the scan. The lymph node uptake could be potential pitfall for cancer staging.
18F-FAPI-42 PET/CT Findings in a Patient With Left Ventricular Mural Thrombus
Authors: Wang Shu , Cheng Zhiming , Cui Yan , Li Xuena , Li Yaming 
Published: January 2024

Abstract

18F-FAPI-42 PET/CT is a novel imaging tool targeting fibroblast activation protein (FAP). We describe the 18F-FAPI-42 PET/CT findings of a left ventricular mural thrombus in a 50-year-old man who had chest tightness. The 18F-FAPI-42 PET/CT showed annular uptake at the apex of the left ventricle, but there was no uptake of 18F-FDG. This case showed that abnormal 18F-FAPI-42 uptake in the heart may be associated with mural thrombus and should be evaluated clinically.
Significantly Higher 68Ga-FAPI Than 18F-FDG Uptake by Hidradenocarcinoma of Head and Neck on PET/CT
Authors: Ding Haoyuan , Wang Yudi , Liang Juan , Liu Ya , Chen Yue 
Published: January 2024

Abstract
Hidradenocarcinoma is quite rare in clinical practice. Herein, we describe the 68Ga-FAPI and 18F-FDG PET/CT findings of hidradenocarcinoma of the head and neck in a 75-year-old man. In the present case, the primary tumor and secondary lesions showed intense accumulation of 68Ga-FAPI but only slight 18F-FDG uptake. This case demonstrates that 68Ga-FAPI PET/CT might be used as a helpful tool for evaluating hidradenocarcinoma.
18F-FAPI-04 PET/CT in a Case of Primary Gastric Plasmacytoma
Authors: Dong Yiyuan , Zhao Tingting , Ma Liqiong , Dong Aisheng , Zhao Qian 
Published: January 2024

Abstract
Primary plasmacytoma of the stomach is very rare. We describe contrast-enhanced CT and 18F-FAPI-04 PET/CT findings in a patient with primary gastric plasmacytoma and Helicobacter pylori infection. The gastric tumor appeared as a large hypervascular polypoid mass on contrast-enhanced CT and showed intense 18F-FAPI-04 uptake with SUVmax of 11.8 on 18F-FAPI-04 PET/CT.
Cranio-Maxillofacial Injuries in Mixed Martial Arts
Authors: Ferretti Fabrizio , Iocca Oreste , Gallesio Cesare , Quaglia Paolo , Ramieri Guglielmo 
Published: January 2024

Purpose:
To describe a case of a maxillofacial trauma that occurred during a mixed martial arts (MMA) match and to perform a literature review of maxillofacial injuries related to MMA match to determine whether preventive models are applicable.

Methods:
The authors described a maxillofacial injury with orbital and optic nerve involvement that happened during a professional MMA match. A literature review on maxillofacial trauma in MMA was conducted on Scopus and Pubmed with specific keywords.

Results:
Open reduction and internal fixation of the maxillofacial complex fractures with right eye optic neuropathy following an MMA match is described. Six articles were selected for the description of trauma in the maxillofacial complex associated with MMA fights.

Discussion:
Literature has paid little attention to injuries during MMA matches. The most common injury locations that emerged from the literature review were the head, face, and neck. Middle facial third injuries were the most common type. Frequently the injury involved the ophthalmic area.

Conclusions:
The timing of maxillofacial trauma in MMA is critical. Protective devices should be strongly promoted to prevent catastrophic consequences.
Clinical Efficacy of Laparoscopic Sentinel Node Navigation Surgery for Stomach Preservation in Patients With Early Gastric Cancer
Authors: Hur Hoon , Lee Young Joon , Kim Young-Woo , Min Jae-Seok , Yoon Hong Man , An Ji Yeong , Eom Bang Wool , Cho Gyu Seok , Park Young-Kyu , Jung Mi Ran , Park Ji-Ho , Hyung Woo Jin , Jeong Sang-Ho , Kook Myeong-Cherl , Han Mira , Nam Byung-Ho , Ryu Keun Won 
Published: January 2024

Objective:
This study aimed to compare laparoscopic standard gastrectomy (LSG) and laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer (EGC) in terms of 5-year long-term oncologic outcomes.

Background:
The oncological safety of LSNNS for EGC has not been confirmed. Three-year disease-free survival (DFS), which is the primary endpoint of phase III multicenter randomized controlled clinical trial [SEntinel Node ORIented Tailored Approach (SENORITA) trial], did not show the noninferiority of LSNNS relative to LSG.

Methods:
The SENORITA trial, a multicenter randomized clinical trial, was designed to show that LSNNS is noninferior to LSG in terms of 3-year DFS. In the present study, we collected 5-year follow-up data from 527 patients recruited in the SENORITA trial as the full analysis set. DFS, overall survival (OS), disease-specific survival (DSS), and recurrence patterns were evaluated using the full analysis set of both LSG (n=269) and LSNNS (n=258).

Results:
The 5-year DFS was not significantly different between the LSG and LSNNS groups (P=0.0561). During the 5-year follow-up, gastric cancer–related events, such as metachronous cancer, were more frequent in the LSNNS group than in the LSG group. However, 10 recurrent cancers in the remnant stomach of both groups were curatively resected by additional gastrectomy and 1 by additional endoscopic resection. Two of the 198 patients who underwent local resection for stomach preservation based on the LSNNS results developed distant metastasis. However, there was no statistically significant difference in the 5-year OS and DSS (P=0.7403 and P=0.9586, respectively) between the two groups.

Conclusions:
The 5-year DFS, DSS, and OS did not differ significantly between the two groups. Considering the benefits of LSNNS on postoperative quality of life, LSNNS could be recommended as an alternative treatment option for EGC.
Stratification of Kidney Transplant Recipients Into Five Subgroups Based on Temporal Disease Trajectories
Authors: Jørgensen Isabella F. , Muse Victorine P. , Aguayo-Orozco Alejandro , Brunak Søren , Sørensen Søren S. 
Published: January 2024

Background.
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Considerable clinical research has focused on improving graft survival and an increasing number of kidney recipients die with a functioning graft. There is a need to improve patient survival and to better understand the individualized risk of comorbidities and complications. Here, we developed a method to stratify recipients into similar subgroups based on previous comorbidities and subsequently identify complications and for a subpopulation, laboratory test values associated with survival.

Methods.
First, we identified significant disease patterns based on all hospital diagnoses from the Danish National Patient Registry for 5752 kidney transplant recipients from 1977 to 2018. Using hierarchical clustering, these longitudinal patterns of diseases segregate into 3 main clusters of glomerulonephritis, hypertension, and diabetes. As some recipients are diagnosed with diseases from >1 cluster, recipients are further stratified into 5 more fine-grained trajectory subgroups for which survival, stratified complication patterns as well as laboratory test values are analyzed.

Results.
The study replicated known associations indicating that diabetes and low levels of albumin are associated with worse survival when investigating all recipients. However, stratification of recipients by trajectory subgroup showed additional associations. For recipients with glomerulonephritis, higher levels of basophils are significantly associated with poor survival, and these patients are more often diagnosed with bacterial infections. Additional associations were also found.

Conclusions.
This study demonstrates that disease trajectories can confirm known comorbidities and furthermore stratify kidney transplant recipients into clinical subgroups in which we can characterize stratified risk factors. We hope to motivate future studies to stratify recipients into more fine-grained, homogenous subgroups to better discover associations relevant for the individual patient and thereby enable more personalized disease-management and improve long-term outcomes and survival.
AImedReport: A Prototype Tool to Facilitate Research Reporting and Translation of AI Technologies in Healthcare
Authors: Brereton Tracey A. , Malik Momin M. , Rost Lauren M. , Ohde Joshua W. , Zheng Lu , Jose Kristelle A. , Peterson Kevin J. , Vidal David , Lifson Mark A. , Melnick Joe , Flor Bryce , Greenwood Jason D. , Fisher Kyle , Overgaard Shauna M. 
Published: January 2024

AbstractAImedReport is a proof-of-concept team-based documentation strategy that consolidates available AI research reporting guidelines and centrally tracks and organizes any information provided as part of following various guidelines. It functions to assist teams by a) outlining phases of the AI lifecycle and clinical evaluation; b) iteratively developing a comprehensive documentation deliverable and historical archive; and c) addressing translation, implementation, and accountability gaps. By acting as a hub for determining what information to capture, it helps navigate team responsibilities, simplify compliance with evaluation and reporting measures, and fulfill requirements to support clinical trial documentation and publications. Here, we give an overview of this system and describe how it can be used to address documentation and collaboration challenges in AI translation.
Evaluating GPT-4 as a Clinical Decision Support Tool in Ischemic Stroke Management
Authors: Haim Amit , Katson Mark , Cohen-Shelly Michal , Peretz Shlomi , Aran Dvir , Shelly Shahar 
Published: January 2024

AbstractCerebrovascular diseases are the second most common cause of death worldwide and one of the major causes of disability burden. Advancements in artificial intelligence (AI) have the potential to revolutionize healthcare delivery, particularly in critical decision-making scenarios such as ischemic stroke management. This study evaluates the effectiveness of GPT-4 in providing clinical decision support for emergency room neurologists by comparing its recommendations with expert opinions and real-world treatment outcomes. A cohort of 100 consecutive patients with acute stroke symptoms was retrospectively reviewed. The data used for decision making included patients’ history, clinical evaluation, imaging studies results, and other relevant details. Each case was independently presented to GPT-4, which provided a scaled recommendation (1-7) regarding the appropriateness of treatment, the use of tissue plasminogen activator (tPA), and the need for endovascular thrombectomy (EVT). Additionally, GPT-4 estimated the 90-day mortality probability for each patient and elucidated its reasoning for each recommendation. The recommendations were then compared with those of a stroke specialist and actual treatment decision. The agreement of GPT-4’s recommendations with the expert opinion yielded an Area Under the Curve (AUC) of 0.85 [95% CI: 0.77-0.93], and with real-world treatment decisions, an AUC of 0.80 [0.69-0.91]. In terms of mortality prediction, out of 13 patients who died within 90 days, GPT-4 accurately identified 10 within its top 25 high-risk predictions (AUC = 0.89 [95% CI: 0.8077-0.9739]; HR: 6.98 [95% CI: 2.88-16.9]), surpassing supervised machine-learning models. This study demonstrates the potential of GPT-4 as a viable clinical decision support tool in the management of ischemic stroke. Its ability to provide explainable recommendations without requiring structured data input aligns well with the routine workflows of treating physicians. Future studies should focus on prospective validations and exploring the integration of such AI tools into clinical practice.
Safety of BNT162b2 mRNA COVID-19 vaccine batches: A nationwide cohort study
Authors: Hviid Anders , Bech Svalgaard Ingrid 
Published: January 2024

AbstractBackgroundThe safety of the BNT162b2 mRNA COVID-19 vaccine has been extensively evaluated since the global rollout began. While serious adverse events are rare, safety issues continue to arise. This study evaluates the claim that earlier small vaccine batches were associated with higher rates of serious adverse events compared to later batches.MethodsA nationwide cohort study was conducted in Denmark, comprising individuals vaccinated with the BNT162b2 vaccine from 52 pre-defined batches classified into three pre-defined groups. Vaccinated individuals were matched 1:1 between batch groups on age, sex, and vaccination priority group. The study outcomes, included 27 serious adverse events, 2 negative control outcomes and all-cause mortality. Cox regression was used to estimate hazard ratios (HRs) comparing rates between batch groups in the 28-days following vaccination. We conducted two comparisons of the early small batches to two groups of larger batches used later in the pandemic.ResultsIn the study period, 9,983,448 vaccinations were administered from batches in the three pre-defined groups. Slightly increased rates of arrhythmia were observed in both study comparisons, HRs 1.25 (95% CI,1.05-1.50) and 1.15 (1.00-1.31), respectively, but sensitivity analyses did not robustly support these associations. For the remaining outcomes, increased rates in both study comparisons were not observed.ConclusionThis nationwide cohort study provides reassurance regarding the safety of the BNT162b2 vaccine across different batches used in Denmark. The findings support the overall safety of the vaccine, with no clinically relevant variations in serious adverse event rates between batches.
Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies
Authors: He Tongchen , Xiao Lanbo , Qiao Yuanyuan , Klingbeil Olaf , Young Eleanor , Wu Xiaoli S. , Mannan Rahul , Mahapatra Somnath , Eyunni Sanjana , Tien Jean Ching-Yi , Wang Xiaoju , Zheng Yang , Kim NamHoon , Zheng Heng , Hou Siyu , Su Fengyun , Miner Stephanie J. , Mehra Rohit , Cao Xuhong , Abbineni Chandrasekhar , Samajdar Susanta , Ramachandra Murali , Parolia Abhijit , Vakoc Christopher R. , Chinnaiyan Arul M. 
Published: January 2024

SUMMARYThe POU2F3-POU2AF2/3 (OCA-T1/2) transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we found that the POU2F3 molecular subtype of SCLC (SCLC-P) exhibits an exquisite dependence on the activity of the mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complex. SCLC-P cell lines were sensitive to nanomolar levels of a mSWI/SNF ATPase proteolysis targeting chimera (PROTAC) degrader when compared to other molecular subtypes of SCLC. POU2F3 and its cofactors were found to interact with components of the mSWI/SNF complex. The POU2F3 transcription factor complex was evicted from chromatin upon mSWI/SNF ATPase degradation, leading to attenuation of downstream oncogenic signaling in SCLC-P cells. A novel, orally bioavailable mSWI/SNF ATPase PROTAC degrader, AU-24118, demonstrated preferential efficacy in the SCLC-P relative to the SCLC-A subtype and significantly decreased tumor growth in preclinical models. AU-24118 did not alter normal tuft cell numbers in lung or colon, nor did it exhibit toxicity in mice. B cell malignancies which displayed a dependency on the POU2F1/2 cofactor, POU2AF1 (OCA-B), were also remarkably sensitive to mSWI/SNF ATPase degradation. Mechanistically, mSWI/SNF ATPase degrader treatment in multiple myeloma cells compacted chromatin, dislodged POU2AF1 and IRF4, and decreased IRF4 signaling. In a POU2AF1-dependent, disseminated murine model of multiple myeloma, AU-24118 enhanced survival compared to pomalidomide, an approved treatment for multiple myeloma. Taken together, our studies suggest that POU2F-POU2AF-driven malignancies have an intrinsic dependence on the mSWI/SNF complex, representing a therapeutic vulnerability.
Refinement of a published gene-physical activity interaction impacting HDL-cholesterol: role of sex and lipoprotein subfractions
Authors: Westerman Kenneth E. , Kilpeläinen Tuomas O. , Sevilla-Gonzalez Magdalena , Connelly Margery A. , Wood Alexis C. , Tsai Michael Y. , Taylor Kent D. , Rich Stephen S. , Rotter Jerome I. , Otvos James D. , Bentley Amy R. , Mora Samia , Aschard Hugues , Rao DC , Gu Charles , Chasman Daniel I. , Manning Alisa K. 
Published: January 2024

AbstractLarge-scale gene-environment interaction (GxE) discovery efforts often involve compromises in the definition of outcomes and choice of covariates for the sake of data harmonization and statistical power. Consequently, refinement of exposures, covariates, outcomes, and population subsets may be helpful to establish often-elusive replication and evaluate potential clinical utility. Here, we used additional datasets, an expanded set of statistical models, and interrogation of lipoprotein metabolism via nuclear magnetic resonance (NMR)-based lipoprotein subfractions to refine a previously discovered GxE modifying the relationship between physical activity (PA) and HDL-cholesterol (HDL-C). This GxE was originally identified by Kilpeläinen et al., with the strongest cohort-specific signal coming from the Women’s Genome Health Study (WGHS). We thus explored this GxE further in the WGHS (N = 23,294), with follow-up in the UK Biobank (UKB; N = 281,380), and the Multi-Ethnic Study of Atherosclerosis (MESA; N = 4,587). Self-reported PA (MET-hrs/wk), genotypes at rs295849 (nearest gene:LHX1), and NMR metabolomics data were available in all three cohorts. As originally reported, minor allele carriers of rs295849 in WGHS had a stronger positive association between PA and HDL-C (pint= 0.002). When testing a range of NMR metabolites (primarily lipoprotein and lipid subfractions) to refine the HDL-C outcome, we found a stronger interaction effect on medium-sized HDL particle concentrations (M-HDL-P;pint= 1.0×10-4) than HDL-C. Meta-regression revealed a systematically larger interaction effect in cohorts from the original meta-analysis with a greater fraction of women (p= 0.018). In the UKB, GxE effects were stronger both in women and using M-HDL-P as the outcome. In MESA, the primary interaction for HDL-C showed nominal significance (pint= 0.013), but without clear differences by sex and with a greater magnitude using large, rather than medium, HDL-P as an outcome. Towards reconciling these observations, further exploration leveraging NMR platform-specific HDL subfraction diameter annotations revealed modest agreement across all cohorts in the interaction affecting medium-to-large particles. Taken together, our work provides additional insights into a specific known gene- PA interaction while illustrating the importance of phenotype and model refinement towards understanding and replicating GxEs.