bluuebunny/crossref_metadata_2025_split huggingface dataset:
It’s Never Too Late for a Diagnosis
Authors: Coelho Mariana , Durães João , Freixo João , Tomás José , Macário Carmo 
Published: October 2023

Background:
Zellweger spectrum disorder (ZSD) (OMIM#214100) is a phenotypic
continuum ranging from severe to mild presentations. ZSD is now used in all individuals with a
defect in one of the 13 ZSD-PEX genes, regardless of phenotype. Diagnosis can be suggested
by abnormal levels of very long-chain fatty acids, phytanic acid, pristanic acid, plasmalogens,
pipecolic acid, or bile acids. However, false negatives are frequent, mostly in older patients.
Definite diagnosis is established in a proband with suggestive clinical findings by identification
of biallelic pathogenic variants in one of the 13 ZSD-PEX genes.

Case Report:
A 39-year-old female patient had a global development delay since her first year
of life. Never developed oral language but had sphincter control and was able to walk and
laugh. At 8 years old, she had her first seizure and lost sphincter control when she was 20 years
old. At 28 years old, she had an episode of status epilepticus, with severe prostration and became bedridden. She is currently mute, without capacity for communication or motor control.
She has no consanguineous parents, has a 35 year old brother with global developmental delay
and their mother had a history of an abortion, without other relevant family history. Brain MRI
of the patient revealed severe leukodystrophy mainly periventricular, bilateral and symmetric,
and less prominent in the cerebellar white matter, with severe cerebral and corpus callosum atrophy. Molecular study with a leukodystrophy gene panela identified a homozygotic pathogenic
variant on PEX 1 gene (NM_000466.3) - c.2528G>A (p.(Gly843Asp)), confirming the diagnosis of ZSD.

Conclusion:
Homozygosity for PEX1 p.Gly843Asp seems to be associated with an intermediate/milder ZSD phenotype,with survival until adulthood. Some patients develop progressive
degeneration of CNS myelin, a leukodystrophy pattern, like this patient, which may lead to regression. This girl with ZSD had a rapid and severe loss of previous skills after a seizure. Even
though there is no specific treatment for this disease, a correct diagnosiswas very important for
the parents and for family genetic counselling.
Citrullinemia and What Else?
Authors: Almeida Joana , Ferreira Fátima , Baptista Nanci , Ferreira Sara , Santos Constança , Diogo Luísa 
Published: October 2023

Introduction:
Citrullinemia type I (CTLN1) is a rare autosomal recessive metabolic
disorder. Symptoms typically include vomiting, lethargy, seizures and coma. In neonatal presentation, death occurs in days if untreated. Survivors may evolve with neurocognitive dysfunction.

Results/Case Report:
Two 10 years old, non-identical, twin sisters (S1; S2) with CTLN1 were
born after a 36W gestation: S1 by eutocic delivery and S2 by cesarean section with nuchal cord
(Apgar score 5/10). On day four, S2 presented hyperammonemia with coma. S1 had no complications. Diagnosis followed that of S2. Neurocognitive development was monitored at 3 months
- 4 years of age with Griffiths Scales: global development quotient kept within the average, but
S2 had a deficit in language and eye and hand coordination. At 5 years, the neurocognitive abilities were evaluated using Wechsler Preschool and Primary Scale of Intelligence – Revised
(WPPSI-R). S2 revealed difficulties in verbal area (vocabulary, comprehension and memorizing
sentences), with a lower average verbal intelligence quotient (IQ). S1 had high average IQ. Due
to learning difficulties, S2 was reassessment at 8 years old with Wechsler Intelligence Scale for
Children - Third edition (WISC-III): full-scale IQ -“extremely low”.

Conclusion:
These non-identical twin sisters share the same citrullinemia type 1 causing variants in the ASS1 gene. Nevertheless, their clinical presentation and neurocognitive evolution are
diverse. Other factors, like the different genetic background and perinatal issues such as the type
of delivery and its circumstances and the neonatal coma episode of S2 may explain the dissimilar evolution. Maximum ammonium levels (and its duration) are critical for the patients’ neurodevelopment: 131 in S1 and 546 umol/l in S2.
An Empirical Study on the Impact of Supply Chain Finance on the Performance of the Automobile Industry in the Post-COVID-19 Era
Authors: Li Xiaowen , Chen Jun 
Published: October 2023

Background:
In recent years, trade on credit has become increasingly common around
the world, exposing companies in the supply chain to significantly increased financial risk due to
extended billing periods. As an innovative financing model, supply chain finance (SCF) has received
a lot of attention.

Objective:
The goal of this work is to examine the impact of supply chain finance on the performance
of the automobile industry in the post-covid-19 era.

Methods:
After an in-depth understanding of the relevant theoretical literature, two models of inquiry
are established in this paper, and the relevant data are collected from the CSMAR database
for a sample of some enterprises in the automotive industry in the listed market, followed by an
empirical analysis using the Stata 16.0. Then, the fixed effects model (FEM) and difference-indifference
model (DID) are used to test the hypothesis.

Results:
The results show a significant impact of supply chain finance on the performance of automobile
firms. It is effective in improving the flow of funds and contributes to the performance
of enterprises in the automotive industry.

Conclusion:
In the context of the pandemic, supply chain finance can effectively help enterprises
reduce the risk of bankruptcy due to capital rupture and provide a guarantee for the sustainable
development of automobile industry enterprises.
Energy Monitoring for Renewable Energy System Using Machine Learning Algorithms
Authors: Ramachandran Muthu Eshwaran , Singh Ramya Ranjit , Balachandran Gurukarthik Babu , Mohan Devie Paramasivam , David Prince Winston , Anantharaman Meenakshi , Ganesan Nirmala 
Published: October 2023

Background:
Consumption of electricity always varies based on demand. The load
cluster pattern aims at categorizing periodical changes over a specific time. Predicting the electric
load was the initial goal of this study. Additionally, the outcomes of the load prediction were
utilized as data for categorizing electrical loads using a descriptive-analytical method.

Objective:
The study has dealt with a matching of load-side electric demand with the electric
supply. To ensure dependable power-generating stability, it is vital to anticipate and categorize
loads. Thus, the research presented here has focused on electrical load forecasting and
classification.

Methods:
Alternative algorithms, including Naive Bayes, decision tree, and support vector
machine classifier, were employed to address the cluster pattern. The data used for this research
presentation was collected from the D Block of the Kamaraj College of Engineering and
Technology, K. Vellakulam, India, every 15 minutes. Multiple unsuitable loaded circumstances
were ignored during the pre-processing of the dataset. Additionally, other algorithms, like Naive
Bayes, decision tree, and support vector machine, were used to categorize the raw data. The
processing of data was done by a feature selection approach.

Results:
The performance was predicted by comparing the entire machine learning algorithms.
Out of the machine learning techniques, an accuracy of 4.2% for Academic Block 4, a precision of
33% for Boys Hostel, a recall score of 4.7% for Academic Block 4, and an F1 score of 5.3% for
Academic Block 4, were obtained.

Conclusion:
In the study, the decision tree algorithm has shown promising performance than the
other machine learning techniques used.
Preliminary Study of Kidney Transplantation from 2007-2019 in Isfahan, Iran
Authors: Tolou-Ghamari Zahra 
Published: October 2023

Background:
The optimal treatment for the End- Stage Renal Disease(ESRD) is called kidney transplantation, which can typically improve quality of life and patient survival.

Aims:
The aim of this investigation was to evaluate clinical and demographic data of kidney transplantation in a main tertiary hospital in Isfahan/Iran.

Objectives:
The published articles confirmed that a successful kidney transplant reduces mortality. Consequently, for further challenges associated with the causes and outcomes, preliminary studies are crucial in a large population of kidney transplant.

Methods:
From the database of hospital and transplant surgery notebook, the features such as, age, duration of surgery, the number of kidney donors (living person or brain death), and predisposing factors for ESRD were extracted and analyzed.

Results:
A total of 688 kidney transplant recipients comprised of males (n= 473M) and females (n= 215) were considered for further analysis. Recipients received kidneys from 482 living and 206 cadaver donors. The mean age of donors versus recipients was 30.4 versus 43.7 years (p≤0.05) respectively. Operation time in the recipients of living versus cadaver donors was 3.7 versus 4 hours. Operation time from 5.5 (the year 2007) reached 3.7 hours (the year 2019). The number of cadaver donors was 3 (the year 2009) which reached at 19 (the year 2019).

Conclusion:
In Isfahan, Iran, more than 50% of the population studied needed kidney transplantation around the age of 45 years, and the number of transplanted men was 2.2 times higher than the females. The mean duration of the operation was significantly reduced, and the number of brain death donors steadily increased. Further, remodelling and analyzing the data obtained from this initial investigation could facilitate resourceful decisions regarding practical aspects of kidney transplantation outcome.
The Efficacy and Feasibility of an Interoceptive Exposure Technique for Preventing the Transition From Subacute to Chronic Back Pain by Altering the Emotional Response to Pain: Protocol for a Pilot Randomized Controlled Trial
Authors: Orenius Tage Ingemar , Ristolainen Leena , Silén Esko , Hurri Heikki 
Published: October 2023

Background
Psychological factors such as stress, anxiety, mood, emotions, cognitive functioning, and pain behavior are relevant to the onset of pain and its continuation in the transition to chronic conditions. Subacute low back pain (LBP), a precursor to chronic LBP, is particularly poorly understood, and its relationships with psychological factors are understudied.

Objective
We will conduct a study aiming to prevent the chronicity of subacute LBP by altering the emotional response to pain using an interoceptive exposure technique (IET). Considering the recent increase in knowledge about psychological risk factors, as well as recent findings in cognitive neuroscience regarding emotional and cognitive background factors in the LBP chronicity process, efforts should be made to discover effective preventive methods.

Methods
We present a novel method aiming to prevent the transition from subacute to chronic back pain by altering the emotional response to pain using an IET. In this pilot randomized controlled trial, participants who are at a higher risk of LBP chronification due to the presence of a biomarker (ie, functional connectivity between the medial prefrontal cortex and nucleus accumbens) will be randomly assigned to the IET intervention group or control group A (treatment as usual). Participants who do not present with the biomarker will be assigned to control group B (treatment as usual) to assess how well this biomarker predicts the chronification of subacute LBP in this study population. Questionnaires measuring the pain experience and psychological distress will be used before the intervention, after the intervention (at 3 months), and at the 12-month follow-up.

Results
This research project will combine 2 novel methods: a biomarker as the inclusion criterion and an IET as the intervention. The comparative study design enables evaluation of the efficacy of the IET, as well as replication of the biomarker’s validity as a possible clinical screening method.

Conclusions
If found to be useful, the IET would offer a cost-effective and reasonable way to develop treatment for acute and subacute back pain conditions. Potential benefits include increased pain management and quality of life for the individual patient with the addition of a potentially useful functional pain management method at the societal level.

Trial Registration
ClinicalTrials.gov NCT05450263; https://clinicaltrials.gov/ct2/show/NCT05450263

International Registered Report Identifier (IRRID)
PRR1-10.2196/45701
Design, Development, and Evaluation of an mHealth App for Reporting of Side Effects During Cytostatic Treatment: Usability Test and Interview Study
Authors: Hægermark Emil Aale , Kongshaug Nina , Raj Sunil Xavier , Hofsli Eva , Faxvaag Arild 
Published: October 2023

Background
Using mobile health (mHealth) interventions such as smartphone apps to deliver health services is an opportunity to engage patients more actively in their own treatment. Usability tests allow for the evaluation of a service by testing it out on the relevant users before implementation in clinical practice.

Objective
The objective of this study was to design, develop, and evaluate the user interface of an app that would aid patients with cancer in reporting a more comprehensive summary of their side effects.

Methods
The usability test was conducted by exposing patients with cancer to a prototype of an mHealth app that allowed for reporting of side effects from a chemotherapy regimen. After solving a set of 13 tasks, the test participants completed a system usability scale questionnaire and were interviewed using a semistructured interview guide. The interviews were later transcribed and analyzed.

Results
The 10 test participants had a mean age of 56.5 (SD 7.11) years. The mean total task completion time for the task-solving session was 240.15 (SD 166.78) seconds. The calculated system usability scale score was 92.5. Most participants solved most of the tasks without any major issues. A minority reported having difficulties using apps on smartphones in general. One patient never achieved a meaningful interaction with our app prototype. Most of those who engaged with the app approved of features that calmed them down, made them more empowered, and put them in control. They preferred to report on side effects in a detailed and concise manner. App features that provided specific advice could provoke both fear and rational action.

Conclusions
The user tests uncovered design flaws that allowed for subsequent refining of an app that has the potential to enhance the safety of patients undergoing home-based chemotherapy. However, a refined version of the app is unlikely to be of value to all patients. Some might not be able to use apps on smartphones in general, or their ability to use apps is impaired because of their disease. This finding should have implications for health care providers’ overall design of their follow-up service as the service must allow for all the patients to receive safe treatment whether they can use an mHealth app or not.
Indução do trabalho de parto em uma maternidade de alto risco: indicações e desfechos.
Authors: Nascimento Paixão Gilvânia Patrícia do , Marques Thaís , Oliveira Josenilde , Santana Maria Cristina , Fraga Chalana 
Published: October 2023

Objetivo: o objetivo do artigo é descrever as principais indicações gestacionais e os desfechos obstétricos e neonatais das induções de trabalho de parto ocorridas nos meses de janeiro a novembro do ano de 2019, num serviço de referência obstétrica do Vale do São Francisco. Metodologia: Estudo quantitativo, transversal de caráter exploratório-descritivo, realizado com prontuário de 244 mulheres submetidas ao processo de indução em um Hospital materno-infantil de alto risco, localizado no Vale do São Francisco, Pernambuco. Resultados: O método mais utilizado foi o misoprostol (85,7%), a maioria (28,7%) das indicações foram realizadas por pré-eclâmpsia, 61,9% das mulheres evoluíram para o parto vaginal, apenas 4,9% apresentaram complicações; 81,6% dos Rns nasceram com boa vitalidade. Conclusão: A indução, caso seja indicada e utilizada da maneira correta, é uma importante estratégia para a redução dos altos índices de cesarianas e apresenta desfechos favoráveis materno-fetal.
Effectiveness of Corticosteroid Therapy in COVID-19 Induced Olfactory Dysfunction: a systematic review and meta-analysis of Randomized Controlled Trials.
Authors: Zaidi Syed Muhammad Mehdi , Naeem Shozab , Chola Muhammad Shuraim , Ashraf Muhammad Hasan , Sahban Lamea bint , Masood Syed Muhammad Ali , MD Muhammad Saad Choudhry , Naseem Laiba , Ali Sabir , Ahmed Muhammad Rauhaan , Khan Muhammad Talha 
Published: October 2023

Introduction: Covid-19 has been strongly associated with the loss of
smell also known as anosmia. It is one of the first symptoms experienced
by patients who encounter covid-19. The condition has been reported to
have a detrimental impact on psychological and emotional well-being,
physical health, and relationships thus compromising the quality of
life. Various reasons have been proposed to justify the cause of
anosmia, with apoptosis of olfactory cells and inflammation of the
mucosa amongst a few. The following study aims to shed light on the
efficacy of intranasal corticosteroids in the treatment of these
conditions. Methods: From their inception to 20 May 2023, a complete
search of electronic databases including PubMed, MEDLINE, Scopus, and
Cochrane was conducted to look for studies consisting of data regarding
short-term or long-term anosmia in COVID-19 patient populations who were
treated using intra-nasal corticosteroids.After a rigorous process of
study selection, 7 studies were shortlisted and utilized to conduct a
meta-analysis. Results: The improvement in the olfactory score at 2 and
4 weeks was statistically higher in the treatment group (Standard Mean
Difference [SMD]= 1.01 [0.07, 1.94], p-value= 0.03) as compared
to the control group (SMD = 1.25 [0.78, 1.73], P = 0.00004).
However, the results in the 4 weeks group were not significant.
Similarly, the effect of corticosteroids in patients in whom anosmia
lasted for more than 4 weeks also turned out to be insignificant (SMD =
0.51 [-0.12, 1.14], a p-value of 0.11, I2 =78%). According to the
subgroup analysis, there were no significant differences in the efficacy
of corticosteroids in short and long-term anosmia (RR = 1.26 [0.83,
1.92] and 1.57 [0.04, 70.02], p-value = 0.13). Conclusion: As per
the findings of the meta-analysis, corticosteroids do play a role in the
improvement of the olfactory dysfunction caused by COVID-19. However,
there was no difference in their efficacy for the treatment of
short-term versus long-term anosmia patients.
Automated parameterization of stomatal conductance models from thermal imagery by leveraging synthetic images generated from Helios 3D biophysical model simulations
Authors: Mayanja Ismael , Yun Heesup , Earles Mason , Bailey Brian N. 
Published: October 2023

Stomatal conductance (g ) is a critical
plant biophysical variable that reflects plant regulation of
CO uptake and associated water loss, yet its direct
measurement is often prohibitively time-consuming. Estimating the
impacts of g indirectly through leaf
temperature (T ) is a common practice,
but is complicated by confounding factors such as ambient conditions,
measurement aggregation scale, sample size, and measurement time.
Using T measurements to instead
determine parameters of a model for g
that can remove these external factors can provide quasi-traits that are
more reliable and heritable. Our objective was to develop an automated
pipeline for g model parameterization
using thermal data, which could be applied within a 3D biophysical model
to predict the impacts of trait variation on canopy-level processes
related to water-use efficiency. Field experiments were conducted on
common bean, cowpea, and sorghum crops, involving high-resolution
thermal measurements obtained from a robotic sensing platform.
Subsequently, a deep learning algorithm was trained using synthetic
thermography data generated using Helios 3D model simulations
encompassing canopy structure, ambient conditions, and
T , enabling the prediction of
long-wave radiation and incident shortwave radiation for each thermal
image pixel. Following this, a leaf-surface energy budget analysis was
applied to the collected field thermal data to predict
g parameters. Validation of these
predictions was performed through comparisons with ground-truth
leaf-level gas exchange data. This pipeline offers a promising pathway
to predictive simulations of water status and transpiration-related
traits, regardless of environmental variation, ultimately enhancing our
understanding of plant responses to changing environmental conditions.
Jurnal Riset dan Inovasi Peternakan
Authors: Adhianto Kusuma 
Published: October 2023

Jurnal Riset dan Inovasi Peternakan(Journal of Research and Innovation of Animals)
Chief EditorKusuma Adhianto
Associate EditorDian SeptinovaRatna ErmawatiFitria Tsani FardaEtha ‘Azizah Hasiib
Editorial BoardRudy SutrisnaFarida FathulAli HusniErwantoRr. RiyantiSyahrio TantaloKhaira NovaSri SuharyatiPurnama Edy Santosa SiswantoLimanTeguh Rafian
NILAI KECERNAAN BAHAN KERING (KcBK) DAN KECERNAAN BAHAN ORGANIK (KcBO) SECARA IN VITRO KLOBOT JAGUNG DENGAN PENGOLAHAN KIMIA DAN BIOLOGI
Authors: Anisa Dahlia Mafida Nur , Liman Liman , Farda Fitria Tsani , Sutrisna Rudy 
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pengolahan amoniasi klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro; mengetahui pengaruh fermentasi klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro; mengetahui pengaruh amofer klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro. Penelitian ini dilakukan di Laboratorium Nutrisi Perah, Fakultas Peternakan, Institut Pertanian Bogor. Rancangan yang digunakan pada penelitian ini adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dengan 4 ulangan, sehingga berjumlah 16 unit percobaan. Adapun rancangan perlakuan yang digunakan sebagai berikut: P1: Kontrol/klobot jagung tanpa perlakuan; P2: Klobot jagung amoniasi menggunakan 2% urea; P3: Klobot jagung fermentasi menggunakan 5% Aspergillus niger; P4: Klobot jagung amofer (amoniasi 2% urea + fermentasi 5% Aspergillus niger). Parameter yang diamati adalah kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) klobot jagung. Hasil penelitian menunjukkan bahwa pengolahan secara kimiawi dan biologi pada klobot jagung tidak memberikan berpengaruh nyata (P>0,05) terhadap KcBK dan KcBO. Kesimpulan dari hasil penelitian ini bahwa uji in-vitro pada perlakuan amoniasi, fermentasi dan amofer tidak berpengaruh nyata (P>0,05) terhadap hasil analisis ragam KcBK dan KcBO; pada hasil analisis ragam KcBK, dan KcBO tertinggi didapat pada perlakuan amoniasi menggunakan urea 2% yaitu 41,58% pada KcBK, dan 47,63% pada KcBO.