bluuebunny/crossref_metadata_2025_split huggingface dataset:
The infundibulochiasmatic angle and the favorability of an endoscopic endonasal approach in type IV craniopharyngioma: illustrative case
Authors: Finger Guilherme , Ruiz Maria Jose C , Salem Eman H , Marquardt Matthew D , Wu Kyle C , Carlstrom Lucas P , Carrau Ricardo L , Prevedello Luciano M , Prevedello Daniel M 
Published: January 2024

BACKGROUND
Lesions located in the floor of the third ventricle are among the most difficult to access in neurosurgery. The neurovascular structures can limit transcranial exposure, whereas tumor extension into the third ventricle can limit visualization and access. The midline transsphenoidal route is an alternative approach to tumor invading the third ventricle if the tumor is localized at its anterior half and a working space between the optic apparatus and the pituitary infundibulum exists. The authors introduce the “infundibulochiasmatic angle,” a valuable measurement supporting the feasibility of the translamina terminalis endoscopic endonasal approach (EEA) for resection of type IV craniopharyngiomas.

OBSERVATIONS
Due to a favorable infundibulochiasmatic angle measurement on preoperative magnetic resonance imaging (MRI), an endoscopic endonasal transsellar transtubercular approach was performed to resect a type IV craniopharyngioma. At 2-month follow-up, the patient’s neurological exam was unremarkable, with improvement in bitemporal hemianopsia. Postoperative MRI confirmed gross-total tumor resection.

LESSONS
The infundibulochiasmatic angle is a radiological tool for evaluating the feasibility of EEA when resecting tumors in the anterior half of the third ventricle. Advantages include reduced brain retraction and excellent rates of resection, with minimal postoperative risks of cerebrospinal fluid leakage and permanent pituitary dysfunction.
Fulminant hemorrhagic course of a thalamic H3 K27-altered diffuse midline glioma in an adult patient: illustrative case
Authors: Poletti Nicolas , Marques Luca Lee , Deigendesch Nikolaus , Soleman Jehuda , Mariani Luigi , Guzman Raphael , Rychen Jonathan 
Published: January 2024

BACKGROUND
H3 K27-altered diffuse midline gliomas (DMGs) are rare tumors, which are, regardless of their histological appearance, classified as World Health Organization grade 4 tumors. They are characterized by a diffuse growth pattern, midline anatomical location, and poor prognosis. Although DMGs occur predominantly in childhood, these tumors can also be found in young adults.

OBSERVATIONS
The authors present a case of a 29-year-old patient who was found unconscious with a Glasgow Coma Scale score of 4, along with abnormal extensor movements and bilateral middilated nonreactive pupils. Computed tomography revealed obstructive hydrocephalus due to an acute hemorrhage in a right thalamic lesion. To drain the hydrocephalus and relieve the ongoing central herniation, emergent placement of a right-sided, and later a left-sided, extraventricular drain was performed. Despite the postoperative resolution of hydrocephalus, the patient died shortly after because of the central brain herniation that had occurred. Brain autopsy revealed a H3 K27-altered DMG in the right thalamus.

LESSONS
Although typically described in the pediatric population and located in the pons, H3 K27-altered DMG should also be considered in young adult patients with midline lesions, particularly if they are located in the thalamus or brainstem. In rare cases, H3 K27-altered DMG may present with an acute tumor-related hemorrhage, leading to a fulminant clinical course.
BRAF-mutated suprasellar glioblastoma mimicking craniopharyngioma: illustrative case
Authors: Zheng Bryan , Shao Belinda , Mingrino Jennifer , Poggi Jonathan , Dowd Richard S , Anthony Douglas C , Donahue John E , Doberstein Curtis E 
Published: January 2024

BACKGROUND
Suprasellar masses commonly include craniopharyngiomas and pituitary adenomas. Suprasellar glioblastoma is exceedingly rare with only a few prior case reports in the literature. Suprasellar glioblastoma can mimic craniopharyngioma or other more common suprasellar etiologies preoperatively.

OBSERVATIONS
A 65-year-old male with no significant history presented to the emergency department with a subacute decline in mental status. Work-up revealed a large suprasellar mass with extension to the right inferior medial frontal lobe and right lateral ventricle, associated with significant vasogenic edema. The patient underwent an interhemispheric transcallosal approach subtotal resection of the interventricular portion of the mass. Pathological analysis revealed glioblastoma, MGMT partially methylated, with a BRAF V600E mutation.

LESSONS
Malignant glioblastomas can mimic benign suprasellar masses and should remain on the differential for a diverse set of brain masses with a broad range of radiological and clinical features. For complex cases accessible from the ventricle where the pituitary complex cannot be confidently preserved via a transsphenoidal approach, an interhemispheric approach is also a practical initial surgical option. In addition to providing diagnostic value, molecular profiling may also reveal therapeutically significant gene alterations such as BRAF mutations.
Spontaneous development and involution of a de novo pseudoaneurysm at the superficial temporal artery–middle cerebral artery bypass anastomotic site in a patient with moyamoya disease: illustrative case
Authors: Ravina Kristine , Patel Biraj , Yim Benjamin 
Published: January 2024

BACKGROUND
De novo pseudoaneurysm formation is a rare complication of extracranial-intracranial bypass surgery.

OBSERVATIONS
The authors report the case of a 28-year-old male who presented with new-onset right temporal and occipital ischemia who was found to have bilateral proximal internal carotid artery occlusion with collateral vasculature formation consistent with moyamoya disease. The patient underwent bilateral superficial temporal artery–middle cerebral artery bypasses. A de novo pseudoaneurysm was found at the left-sided bypass distal anastomotic site recipient vessel 1 month after the surgery. The pseudoaneurysm demonstrated a progressive reduction in size and eventual complete involution at 6 months after surgery.

LESSONS
Limited literature reports extracranial-intracranial bypass-associated aneurysms treated primarily with either clipping or resection and reanastomosis. The authors demonstrate, for the first time, a progressively benign natural history course of an extracranial-intracranial bypass distal anastomotic site pseudoaneurysm.
Giant skull base periosteal chondroma treated with endonasal endoscopic surgery: illustrative case
Authors: Nakase Kenta , Nishimura Fumihiko , Kakutani Miho , Morisaki Yudai , Yokoyama Shohei , Matsuda Ryosuke , Takeshima Yasuhiro , Yamada Shuichi , Takeda Maiko , Nakagawa Ichiro , Park Yong-Soo 
Published: January 2024

BACKGROUND
Intracranial chondroma is an extremely rare type of tumor composed of mature hyaline cartilaginous tissues. No previous cases of skull base periosteal chondroma have been presented.

OBSERVATIONS
A 31-year-old male had progressive memory loss and diminished motivation for the previous 1.5 years. Magnetic resonance imaging revealed a giant tumor with partial calcification arising from the upper clivus and extending to the prepontine cistern. Compression of the brainstem and hypothalamus was significant. Surgery was performed and intentionally limited to an intracapsular resection with endoscopic endonasal surgery (EES), and the brainstem and hypothalamus were successfully decompressed. Pathological examination findings showed a composition of hyaline cartilage with chondrocyte clusters. Genetic testing with next-generation sequencing indicated alternations in IDH1 R132C, KDR Q472H, IDH2 I142L, and TP53 P72R. On the basis of these findings, a diagnosis of periosteal chondroma was made. Postoperatively, complete relief from all symptoms was noted, and MRI one year later showed no evidence of tumor regrowth.

LESSONS
This is the first known report of skull base periosteal chondroma. Genetic testing was useful for confirming the diagnosis, and EES was effective for treatment. Should such a tumor show adhesion to an important structure, an intracapsular excision can be beneficial for avoiding complications.
Efficacy, Effectiveness, and Safety of Interventions for Von Hippel-Lindau Associated Renal Cell Carcinoma: A Systematic Literature Review
Authors: Jonasch Eric , Balijepalli Chakrapani , Yan Kevin , Gullapalli Lakshmi , Li Joyce , Sundaram Murali 
Published: January 2024

Background: A small proportion of renal cell carcinoma (RCC) are associated with hereditary syndromes such as von Hippel-Lindau disease (VHL) and are commonly treated with surgical interventions. More recently, systemic treatments for VHL-associated RCC have been assessed as an alternative to surgery. Methods: A systematic literature review was conducted by searching MEDLINE, EMBASE, and Cochrane Registry of Controlled Trials to collect and interpret published evidence on treatments for VHL-associated RCC patients to better understand the treatment landscape. Results: This review identified 32 primary studies, comprised of single-arm clinical trials and real-world studies assessing systemic, surgical, radiological, or image guided ablation interventions. In clinical trials, treatment with sunitinib and pazopanib showed an objective response in 33% and 52% of RCC lesions respectively. For patients treated with belzutifan, 64% of patients showed an objective response, of which 7% were complete response and 57% were partial responses with a 24-month PFS rate of 96%. In real-world studies, treatment with sunitinib, pazopanib, axitinib, and sorafenib showed an objective response in 40%, 0%, 33%, and 25% of RCC lesions respectively, and all the responses were partial. In the studies assessing surgical, radiological, or image guided ablation interventions primary failure/re-intervention rates ranged from 2% to 84%. Conclusion: Local procedures are still a mainstay in the management of patients with non-metastatic VHL-associated RCC although multiple procedures incur an increasing rate of complications. A limited number of clinical trials and real-world studies evaluated VEGF-TKIs for the treatment of VHL-RCC, while responses were observed, long term treatment was limited by toxicities.
Missing prognostic value of soluble PD-1, PD-L1 and PD-L2 in lung cancer patients undergoing chemotherapy – A CEPAC-TDM biomarker substudy
Authors: Geiger Kimberly , Joerger Markus , Roessler Max , Hettwer Karina , Ritter Christoph , Simon Kirsten , Uhlig Steffen , Holdenrieder Stefan 
Published: January 2024

BACKGROUND: Programmed cell death receptors and ligands in cancer tissue samples are established companion diagnostics for immune checkpoint inhibitor (ICI) therapies. OBJECTIVE: To investigate the relevance of soluble PD-1, PD-L1 and PD-L2 for estimating therapy response and prognosis in non-small cell lung cancer patients (NSCLC) undergoing platin-based combination chemotherapies. METHODS: In a biomarker substudy of a prospective, multicentric clinical trial (CEPAC-TDM) on advanced NSCLC patients, soluble PD-1, PD-L1 and PD-L2 were assessed in serial serum samples by highly sensitive enzyme-linked immunosorbent assays and correlated with radiological response after two cycles of chemotherapy and with overall survival (OS). RESULTS: Among 243 NSCLC patients, 185 achieved response (partial remission and stable disease) and 58 non-response (progression). The distribution of PD-1, PD-L1 and PD-L2 at baseline (C1), prior to staging (C3) and the relative changes (C3/C1) greatly overlapped between the patient groups with response and non-response, thus hindering the discrimination between the two groups. None of the PD markers had prognostic value regarding OS. CONCLUSIONS: Neither soluble PD-1, PD-L1 nor PD-L2 did provide clinical utility for predicting response to chemotherapy and prognosis. Studies on the relevance of PD markers in ICI therapies are warranted.
ANALISIS PENGEMBANGAN SUMBER DAYA ALAM DALAM PERCEPATAN PEMULIHAN EKONOMI PASCA COVID-19 DI DESA SUNGAI ARA
Authors: Latifah Ritma , Helmi  , Rahman Taufik 
Published: January 2024

Desa Sungai Ara masih banyak yang memiliki usaha atau mata pencaharian tetap dibidang pertanian dan perkebunan terutama pinang dan kepala sawit, hal ini dapat di indikasikanbahwa masyarakat Desa Sungai Ara kurang dalam ilmu pengetahuan dibidang pertanian dan perkebunan dikarenakan tidak adanya tenaga ahli yang mendampingi mereka dalam melakukan pekerjaannya. Hal ini yang menyebabkan warga Desa Sungai Ara belum terlepas dari kemiskinan. Padahal Desa mereka memiliki Potensi yang bisa dikembangkan. Permasalahan adalah bagaimana mengembangkan sumber daya alam dalam meningkatkan pemulihan ekonomi desa Pasca Covid-19 di Desa Sungai Ara Kecamatan Kempas dan apa saja faktor penghambat serta faktor pendukungnya. Memberikan edukasi atau alternatif kepada masyarakat merupakan salah satu hal yang bisa dilakukan untuk mengembangkan sumber daya alam dan sumber daya manusianya agar mendapatkan hasil yang lebih baik dalam penjualan pinang dan kelapa tersebut. Peneliti memberikan gagasan dan pendapat mengenai bagaimana Analisis Pengembangan Sumber Daya Alam Dalam Percepatan Pemulihan Ekonomi Desa Pasca Covid-19 di Desa Sungai Ara Kecamatan Kempas. Dengan mengembangkan dan melakukan Inovasi terhadap hasil panen pinang dan kelapa sehingga ide-ide kreatif pun dapat tersalurkan dengan baik seperti membuat kopi dari pinang sehingga dapat menjadikan adanya peningkatan dan pemanfaatan buah pinang menjadi harga yang lebih tinggi.
PENERAPAN MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN HASIL BELAJAR SISWA SMA NEGERI 10 KOTA TERNATE KELAS X PADA MATERI PENCEMARAN LINGKUNGAN
Authors: Ujud Sartika , Nur Taslim D , Yusuf Yusmar , Saibi Ningsi , Ramli Muhammad Riswan 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui penerapan model pembelajaran Discovery learning dalam meningkatkan hasil belajar siswa SMA Negeri 10 Kota Ternate kelas X IPA 3. Metode penelitian yang digunakan adalah penelitian tindakan kelas (PTK) dengan mengunakan dua siklus. Setiap siklus terdapat empat tahap yaitu: (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi. Hasil evaluasi peserta didik pada siklus I dari 30 orang, terdapat 14 peserta didik yang memenuhi kriteria ketuntasan Minimal (KKM) atau 47%. Sisanya, peserta didik yang belum memenuhi KKM sebanyak 16 orang atau 53%. Nilai rata-rata siklus I yaitu 70 sedangkan nilai KKM mata pelajaran biologi adalah 72. Hasil evaluasi peserta didik pada siklus II terjadi peningkatan. Peserta didik yang berumlah 30 orang dinyatakan tuntas atau 100% dengan memperoleh nilai rata-rata 80. Hasil observasi aktivitas peserta didik dalam kegiatan belajar mengajar selama siklus I telah tergolong baik, hal ini dapat dilihat dari skor rata-rata yang diperoleh yaitu 69. Dan siklus II mendapatkan hasil observasi aktivitas peserta didik dalam kegiatan belajar mengajar tergolong tinggi dengan perolehan 100%. Hasil aktivitas guru model pada siklus I dan siklus II tergolong lebih baik dalam proses belajar mengajar dengan model pembelajaran Discovery Learning. Hal tersebut dapat dilihat pada aktivitas guru dimana pada siklus I, 71% sedangkan pada siklus II, 100%.
Efektivitas Model PBL Berbasis Etnomatematika Terhadap Kemampuan Pemecahan Masalah Matematika Sekolah Dasar
Authors: Andriyanti Bela Widya , Prihastari Ema Butsi 
Published: January 2024

Abstrak. Penelitian ini bertujuan untuk mengetahui efektivitas model PBL berbasis etnomatematika terhadap kemampuan pemecahan masalah matematika. Â Penelitian ini menggunakan metode kuantitatif dengan desain One-Group Pretest Posttest. Â Subyek penelitian terdiri dari 29 peserta didik kelas V SD Negeri Wirun 04. Teknik Â sampling Â menggunakan sampling jenuh sehingga sampel dan populasi sama. Teknik pengumpulan data berupa tes, observasi, dan dokumentasi. Â Kelayakan instrumen di uji menggunakan uji validitas dan uji reliabilitas. Analisis data meliputi Â uji normalitas, uji Â paired sample t-test, dan uji n-gain. Â Hasil uji normalitas menyatakan data terdistribusi normal. Hasil uji paired sample t-test diperoleh nilai signifikansi 0,000 Â < 0,05, dan thitung> ttabel (13,792 > 1,701), menunjukkan terdapat perbedaan nilai rata-rata sehingga model PBL berbasis etnomatematika berpengaruh terhadap kemampuan pemecahan masalah matematika. Hasil uji n-gain menunjukkan peningkatan kemampuan pemecahan masalah matematika sebesar 57,2, ditafsirkan cukup efektif. Â Sehingga, disimpulkan bahwa model PBL berbasis etnomatematika cukup efektif terhadap kemampuan pemecahan masalah matematika siswa kelas V SD Negeri Wirun 04.Kata Kunci: Pembelajaran Berbasis Masalah, Etnomatematika, Kemampuan Pemecahan Masalah, Sekolah Dasar.
Efektivitas Penggunaan Media Pembelajaran Virtual Reality terhadap Hasil Belajar Siswa pada Pembelajaran IPA di SD
Authors: Aini Novita Nur , Azizah Milatul , Bekti Rofi' Setia , Thohir M. Anas 
Published: January 2024

Hasil belajar siswa dalam pembelajaran IPA di sekolah dasar dinilai perlu mendapatkan perhatian yang lebih baik, terlebih dalam memenuhi tuntutan abad 21. Penelitian ini bertujuan untuk memberikan rekomendasi media pembelajaran kepada pendidik serta mengetahui efektivitas penggunaan media Virtual Reality (VR) dalam meningkatkan hasil belajar IPA di sekolah dasar. Metode penelitian yang digunakan adalah quasi eksperiment. Sampel diambil dari 2 sekolah yakni SD Negeri Sugihwaras 1 di Kabupaten Jombang dan UPT SD Negeri Tulungrejo 02 di Kabupaten Blitar, sedangkan populasi merupakan sekolah dasar di Jawa Timur. Adapun pengambilan sampel dilakukan dengan teknik purposive sampling. Pengumpulan data dilakukan dengan memberikan pre-test dan post-test kepada kedua kelompok. Hasil data akan dianalisis menggunakan SPSS kemudian diinterpretasikan. Berdasarkan hasil penelitian, diperoleh nilai sig. (2-tailed) sebesar 0,096 > 0,05. Ini berarti penggunaan media VR dalam pembelajaran IPA di SD terbukti efektif diterapkan guna meningkatkan hasil belajar siswa. Angka ini juga dipengaruhi oleh tingginya motivasi belajar kelas eksperimen yang menggunakan VR dari pada kelas kontrol yang diperlakukan pembelajaran secara konvensional.Kata Kunci:Hasil belajarMedia pembelajaranVirtual RealityPembelajaran IPA
Stability in biosensors derived from domain map analysis of bibliometric data
Authors: Klos-Witkowska Aleksandra , Martsenyuk Vasyl 
Published: January 2024

In the presented work, advanced methods of analysis and visualization were used to compile trends and patterns in the scientific literature. The most relevant information for the stability of biosensors was selected on the basis of clusters constructed on the basis of keywords. The most significant publications in the clusters appearing over time were analyzed. The most explosive publications were identified, i.e., those that have had the greatest impact on science in the area of the subject under study. The scientific trend in the development of biosensor stability was determined on the basis of the most frequently cited words in recent publications. A map of cooperation and networking between countries in the field of interest of the above topic was presented. Leaders were identified by country of origin.Systematic Review Registration:https://ubb.edu.pl.
Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews
Authors: Nucera Saverio , Serra Maria , Caminiti Rosamaria , Ruga Stefano , Passacatini Lucia Carmela , Macrì Roberta , Scarano Federica , Maiuolo Jessica , Bulotta Rosamaria , Mollace Rocco , Bosco Francesca , Guarnieri Lorenza , Oppedisano Francesca , Ilari Sara , Muscoli Carolina , Palma Ernesto , Mollace Vincenzo 
Published: January 2024

IntroductionCardiovascular diseases (CVDs) are the most important cause of premature death and disability worldwide. Environmental degradation and cardiovascular diseases are two keys to health challenges, characterized by a constant evolution in an industrialized world that exploits natural resources regardless of the consequences for health. The etiological risk factors of CVDs are widely known and include dyslipidemia, obesity, diabetes, and chronic cigarette consumption. However, one component that is often underestimated is exposure to heavy metals. The biological perspective explains that different metals play different roles. They are therefore classified into essential heavy metals, which are present in organisms where they perform important vital functions, especially in various physiological processes, or non-essential heavy metals, with a no biological role but, nonetheless, remain in the environment in which they are absorbed. Although both types of metal ions are many times chemically similar and can bind to the same biological ligands, the attention given today to nonessential metals in several eukaryotic species is starting to raise strong concerns due to an exponential increase in their concentrations. The aim of this systematic review was to assess possible correlations between exposure to nonessential heavy metals and increased incidence of cardiovascular disease, reporting the results of studies published in the last 5 years through March 2023.MethodsThe studies includes reviews retrieved from PubMed, Medline, Embase, and Web of Science databases, in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and following the PICO (Population Intervention Comparison Outcome Population) framework.ResultsEight reviews, including a total of 153 studies, were identified. Seven of these review enlighted the association between CVDs and non-essential heavy metals chronic exposure.DiscussionIt is evident that exposure to heavy metals represent a risk factor for CVDs onset. However, further studies are needed to better understand the effects caused by these metals.
Implantable cardiac monitors: artificial intelligence and signal processing reduce remote ECG review workload and preserve arrhythmia detection sensitivity
Authors: Bisignani Giovanni , Cheung Jim W. , Rordorf Roberto , Kutyifa Valentina , Hofer Daniel , Berti Dana , Di Biase Luigi , Martens Eimo , Russo Vincenzo , Vitillo Paolo , Zoutendijk Marlies , Deneke Thomas , Köhler Irina , Schrader Jürgen , Upadhyay Gaurav 
Published: January 2024

IntroductionImplantable cardiac monitors (ICMs) provide long-term arrhythmia monitoring, but high rates of false detections increase the review burden. The new “SmartECG” algorithm filters false detections. Using large real-world data sets, we aimed to quantify the reduction in workload and any loss in sensitivity from this new algorithm.MethodsPatients with a BioMonitor IIIm and any device indication were included from three clinical projects. All subcutaneous ECGs (sECGs) transmitted via remote monitoring were classified by the algorithm as “true” or “false.” We quantified the relative reduction in workload assuming “false” sECGs were ignored. The remote monitoring workload from five hospitals with established remote monitoring routines was evaluated. Loss in sensitivity was estimated by testing a sample of 2000 sECGs against a clinical board of three physicians.ResultsOf our population of 368 patients, 42% had an indication for syncope or pre-syncope and 31% for cryptogenic stroke. Within 418.5 patient-years of follow-up, 143,096 remote monitoring transmissions contained 61,517 sECGs. SmartECG filtered 42.8% of all sECGs as “false,” reducing the number per patient-year from 147 to 84. In five hospitals, nine trained reviewers inspected on average 105 sECGs per working hour. This results in an annual working time per patient of 83 min without SmartECG, and 48 min with SmartECG. The loss of sensitivity is estimated as 2.6%. In the majority of cases where true arrhythmias were rejected, SmartECG classified the same type of arrhythmia as “true” before or within 3 days of the falsely rejected sECG.ConclusionSmartECG increases efficiency in long-term arrhythmia monitoring using ICMs. The reduction of workload by SmartECG is meaningful and the risk of missing a relevant arrhythmia due to incorrect filtering by the algorithm is limited.