bluuebunny/crossref_metadata_2025_split huggingface dataset:
TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemia
Authors: Ounalli Asma , Moumni Imen , Mechaal Amal , Chakroun Aya , Barmat Mbarka , Rhim Rim El Elj , Menif Samia , Safra Ines 
Published: October 2023

BackgroundGenetic variations in TP53 gene are known to be important in chronic lymphocytic leukemia (CLL) and may cause its inactivation which is associated with an aggressive form of the disease. Single nucleotide polymorphism (rs1042522:G&gt;C) in TP53 gene at codon 72 encodes for arginine (Arg) or proline (Pro) variant which results in amino acid substitution affecting the apoptotic potential of TP53 protein. The aim of this study was to assess the correlation between TP53 codon 72 polymorphism and risk susceptibility as well as severity of CLL among Tunisian patients.Materials and methodsA case-control study was conducted in Tunisia from February 2019 to November 2021, 160 de novo CLL patients and 160 healthy volunteers matched in age and gender were involved. DNA was extracted from peripheral blood mononuclear cells and the rs1042522 was analyzed using PCR-RFLP.ResultsPro variant was associated with higher susceptibility to CLL than Arg variant (p= 0.023). A significant association was found between Pro variant and prognostic classification of Binet stage C (p= 0.001), low hemoglobin level (p= 0.003) and low platelet count (p= 0.016).ConclusionWe suggest that Pro variant may increase the risk of developing CLL in our population and could be associated with the severity of the disease.
Prognostic significance of the systemic immune-inflammation index in patients with extranodal natural killer/T-cell lymphoma
Authors: Hai Tao , Wu Wanchun , Ren Kexin , Li Na , Zou Liqun 
Published: October 2023

BackgroundThe systemic immune-inflammation index (SII) is based on the neutrophil, platelet, and lymphocyte counts, and has been identified as a prognostic marker in multiple types of cancer. However, the potential value of the SII for predicting survival outcomes in patients with extranodal natural killer/T-cell lymphoma (ENKTCL) has not been investigated thus far.MethodThis study included 382 patients with ENKTCL treated with asparaginase-base regimens from 2021 to 2017 in West China Hospital (Chengdu, China). Clinical and demographic variables, as well as the prognostic value of the SII, were analyzed using Cox proportional hazards regression analysis.ResultsThe complete and objective response rates were 55.8% and 74.9%, respectively. Patients with high SII were associated with a lower rate of complete response, higher rate of B symptoms, and serum lactate dehydrogenase levels above or equal to the upper limits of normal (p &lt; 0.01). Patients with low SII were linked to better overall survival and progression-free survival than those with high SII (p &lt; 0.01). Patients with early-stage disease or prognostic model for natural killer lymphoma with Epstein–Barr virus, defined as the low-risk group, could be further stratified according to the SII (p &lt; 0.01). Negative prognostic factors were determined using the Cox proportional hazards regression analysis, which identified four variables: Eastern Cooperative Oncology Group performance status score ≥2, Stage III/IV disease, positivity for Epstein–Barr virus DNA in plasma, and high SII. Predictive nomograms for the prediction of 3- and 5-year overall survival, as well as progression-free survival, were constructed based on those four variables. The nomograms demonstrated favorable discriminating power.ConclusionThe SII is a novel prognostic marker for ENKTCL, which may be used for the prediction of poorer survival in low-risk patients.
Case report: Diagnosis and treatment of DGAT1 deficiency-induced congenital diarrhea in two cases and literature review
Authors: Li Jian , Sun Mei , Guo Jing , Xu Lingfen 
Published: October 2023

IntroductionCongenital diarrhea is a rare inherited intestinal disease characterized by persistent and severe diarrhea and malabsorption in the first few weeks after birth, which can be life-threatening. Some congenital diarrheal diseases are associated with mutations in the diacylglycerol acyltransferase 1 (DGAT1) gene.Case descriptionsThis study delineated 2 cases of diarrhea and growth retardation, subsequently confirmed as congenital diarrhea via genetic testing, revealing that the etiology involved compound heterozygous mutations in the DGAT1 gene.Diagnostic assessmentsHigh-MCT milk powder did not obtain an ideal outcome, whereas low-fat diets improved the symptoms of diarrhea and increased the body weigths.DisscussionThe two cases facilitated our understanding of the clinical features of, and treatments for, patients harboring a DGAT1 mutation and enriched the existing DGAT1 mutation database.
Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
Authors: Kelly Melani R. , Emerson Dawn M. , McDermott Brendon P. , Atkins Whitley C. , Butts Cory L. , Laursen R. Mark , Troyanos Christopher , Duckett Andrew , Siedlik Jacob 
Published: October 2023

Gastrointestinal (GI) disturbances are a prevalent cause of marathon related complaints, and in extreme cases can promote life-threatening conditions such as exertional heat stroke. Our aim was to study intestinal cell injury [via intestinal fatty acid binding protein (I-FABP)] and perceived GI distress symptoms among marathon runners. We also examined potential risk factors (e.g., inadequate sleep) that could exacerbate GI disturbances in healthy, trained endurance runners. This was a parallel mixed-methods study design. 2019 Boston Marathon participants were recruited via email and subjects completed surveys before the race describing demographics and training history. Participants completed a GI questionnaire to assess presence and severity of symptoms, a survey regarding risk factors (e.g., recent illness, medications) that could promote GI disturbances, and provided a urine sample at three time points (immediately pre-race, post-race, and 24-h post-race). Due to weather, blood samples were only collected immediately and 24-h post-race. A total of 40 runners (males: n = 19, age = 44.9 ± 10.8 years; females: n = 21, age = 44.8 ± 10.6 years) completed this study. I-FABP significantly decreased from post-race (3367.5 ± 2633.5 pg/mL) to 24-h post-race (1657.3 ± 950.7 pg/mL, t (39) = −4.228, p &lt; .001, d = −.669). There was a significant difference in overall GI symptom scores across the three time points (F (2, 39) = 41.37, p &lt; .001). The highest average score occurred post-race (.84 ± .68), compared to pre-race (.09 ± .12) and 24-h post-race (.44 ± .28). Post-race I-FABP (r = .31, p = .048) and post-race urine specific gravity (r = .33, p = .041) were significantly correlated with post-race GI symptom scores. Our study provides further support to the individualized nature of GI disturbances, with participants experiencing a wide range of risk factors that can influence the extent of GI damage and perceived symptoms during and after exercise.
Development and validation of a personal responsibility scale for Chinese college students
Authors: Ren Yunzhe , Wu Jixia , Qin Hong 
Published: October 2023

IntroductionThe complexity of the concept of responsibility has led to a relative lack of measuring tools. Meanwhile, the widely used measurement of conscientiousness in the Big Five personality traits suffers from inconsistencies in measuring personal responsibility. Therefore, measuring personal responsibility must be adapted to its cultural context. Spurred by these reasons, we developed a “Chinese College Student Personal Responsibility Scale” (CCSPRS) based on local theoretical foundations. Furthermore, we conducted a preliminary exploration using the new scale, examining the correlations between college students’ responsibility, trust propensity, and prosocial behavior tendencies.MethodsThe initial version of the scale was subjected to item analysis, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA) to form the formal version of the scale. A total of 1,038 college students were assembled. The reliability and validity of the scale were also analyzed. We collected data using the proposed CCSPRS, Interpersonal Trust Scale, and Prosocial Tendencies Measure Questionnaire and obtained 301 valid questionnaires.ResultsThe scale’s reliability and validity indicators met the development requirements, and the investigation revealed that women students scored significantly higher in responsibility than men students. Additionally, the responsibility scores were relatively high in the first and fourth years and low in the second and third years, presenting an approximate U-shaped trend. Besides, the college students’ personal responsibility, trust propensity, and prosocial behavior tendencies were positively correlated.DiscussionThe proposed CCSPRS is an effective tool for measuring personal responsibility among Chinese college students. Additionally, this study analyzed the internal beliefs of individuals and concluded that personal responsibility, prosocial behavior, and trust propensity are closely interconnected, especially the relationship between responsibility and prosocial behavior.
“To fast or not to fast?” Ramadan and religiosity through the eyes of people with bipolar disorder: an exploratory study
Authors: Mejri Imen , Ouali Uta , Gronholm Petra C. , Zgueb Yosra , Ouertani Abdelhafidh , Nacef Fethi 
Published: October 2023

BackgroundThe month of Ramadan, due to its changes in social rhythms, can seriously affect the course of bipolar disorder (BD). Therefore, psychiatrists sometimes find it necessary to discourage Ramadan practices, especially fasting, although taking part in this practice can give a sense of belonging and accomplishment to patients. Research on this subject is limited.AimThe aim of the present work was to explore: (i) religious practices with special attention to Ramadan before and after the onset of BD, (ii) the perceptions and behaviors related to not fasting during Ramadan in patients with BD and their families’ attitudes, (iii) religiosity and self-stigmatization and their relationships with religious practices, and (iv) the doctor-patient relationship around fasting.MethodsWe conducted a retrospective, cross-sectional and descriptive study in clinically stabilized patients with BD in a public mental hospital and in a private psychiatric practice in Tunis, Tunisia. Socio-demographic and clinical data, as well as data related to general religious practices and Ramadan practices were collected using a self-established questionnaire. We assessed (i) religiosity of the patients with the Duke University Religion Index and (ii) self-stigma using the Internalized Stigma of Mental Illness scale.ResultsOur sample consisted of 118 patients of whom 65.3% were fasting regularly before BD onset. More than half had stopped this practice following BD onset. Of the patients who did not fast, 16% felt guilty about this and 4.9% reported receiving negative remarks from their surroundings. High self-stigma scores were observed in 11% of the patients. Self-stigma was associated significantly with negative perception of not fasting, negative remarks regarding not fasting and taking both meals at regular times during Ramadan. The decision whether to fast or not was taken without seeking medical advice in 71.2% of the sample, and 16.9% of the sample reported that their psychiatrist had spontaneously approached the issue of Ramadan fasting.ConclusionReligiosity and more specifically the practice of Ramadan remains an important point that should be considered when treating patients with psychiatric problems. It seems necessary that healthcare professionals should integrate the positive and the negative side of fasting into their reflections. Our results remain exploratory and encourage further work on the subject.
Association between weight change and the predicted 10-year risk for atherosclerosis cardiovascular disease among U.S. older adults: data from National Health and Nutrition Examination Survey 1999–2018
Authors: Peng Yuxuan , Li Hongzheng , Liao Feifei , Lu Jieming , Yang Wenwen , Tan Ling , Lu Aimei , Wei Yue , Long Linzi , Qu Hua , Fu Changgeng 
Published: October 2023

BackgroundIt remains controversial regarding the association between weight change and cardiovascular disease risk in older adults (aged ≥60 years). This study aimed to evaluate the association between weight change and the predicted 10-year atherosclerotic cardiovascular disease (ASCVD) risks in older adults.MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES). Older adults aged 60–79 years who were free of self-reported ASCVD at the time of the NHANES interview were included. Data were collected from January 1999 to December 2018 and analyzed in March 2022. We focused on the associations between weight change and the 10-year ASCVD risks with the percentage change in weight during short-term (1 year) and long-term (10 years), which categorized as moderate to high weight loss (≥10%), small weight loss (5.1–9.9%), stable weight (±5%), small weight gain (5.1–9.9%), and moderate to high weight gain (≥10%).ResultsThe number of participants was 1,867 (mean age 67.49 years; 42.10% female) for the long-term interval (10 years) in our analysis, and 1894 for the short-term interval (1 years). We only observed an inverse association between long-term weight loss and the 10-year ASCVD risk in fully adjusted model (loss ≥ 10%: β = 2.52, 95%CI = 0.98, 4.05; loss 5.1% ~ 9.9%: β = 2.99, 95% CI = 1.30, 4.68), but all intervals of weight gain ≥5% were not significant associated with higher risk than stable weight. However, in the subgroup analyses, the association between long-term weight loss and the 10-year ASCVD risk was not significant in old-old (aged 75–79), obesity (BMI ≥ 35 kg/m2), intentional weight loss, moderate physical activity and diabetics.ConclusionOlder adults (aged 60–79 years) with weight loss &gt;5% over the past 10 years have excess predicted 10-year ASCVD risk. Our study supports the benefits of stable weight in promoting cardiovascular health in older adults.
Associations of handgrip weakness and asymmetry with new-onset stroke in Chinese middle-aged and older adults: a cohort study
Authors: Zhang Yuying , Chen Weiqing , Cao Bing , Lin Li , Li Jinghua , Guo Vivian Yawei 
Published: October 2023

BackgroundWeak handgrip strength (HGS) has been linked to adverse health outcomes including stroke. However, the joint associations of HGS weakness and asymmetry between limbs with stroke incidence remain underexplored.MethodsThis cohort study analyzed data of participants aged ≥45 years from three waves (2011, 2013, and 2015) of the China Health and Retirement Longitudinal Study. Weak HGS was defined according to the recommendation of European Working Group on Sarcopenia in Older People. Asymmetric HGS was defined if the HGS ratio of both hands was over 1.1 or below 0.9. New-onset stroke was confirmed through self-report of physician’s diagnosis.ResultsA total of 10,966 participants without stroke at baseline were included in the analysis. During the 4 years follow-up, there were 262 (2.39%) new-onset stroke cases. Compared to individuals with non-weak and symmetric HGS, those with HGS asymmetry alone and weakness alone were associated with hazards of 1.09 (95% confidence interval [CI]: 0.80–1.48) and 1.27 (95%CI: 0.86–1.88) for new-onset stroke, respectively, while co-occurrence of both HGS asymmetry and weakness was associated with 1.80 (95%CI: 1.24–2.60) greater hazard for new-onset stroke after controlling for confounders. Such associations were consistent in older adults aged ≥60 years, but not in those aged&lt;60 years.ConclusionIndividuals with both weak and asymmetric HGS tended to have greater risk of new-onset stroke, compared to those with normal HGS, or with either weak or asymmetric HGS alone. Our finding suggested that examining HGS asymmetry alongside weakness may help to improve the risk-stratification and target prevention of stroke, particularly in the older population.
Prevalence and associated factors of probable depression amongst pregnant and parenting young females: a comparison of adolescents and young adults in rural South Africa
Authors: Seakamela K. P. , Mashaba R. G. , Ntimana C. B. , Mbombi M. O. , Tlouyamma J. , Mphekgwana P. , Nemuramba R. , Mothapo K. , Muthelo L. , Mabila L. N. , Dhau I. , Maimela E. 
Published: October 2023

BackgroundPregnant teenagers have been reported to have an increased likelihood of experiencing depression than their non-pregnant peers. There is little research on the risk factors for depression in rural Black adolescents and young adults, especially after the Covid-19 pandemic. Therefore, the current study aimed to identify the prevalence of probable depression and associated factors amongst pregnant and parenting young females.MethodThe study was a cross-sectional design, consisting of 362 pregnant and parenting adolescents and young adults aged 14–22. The study used the Edinburgh Postnatal Depression Scale (EPDS) to measure probable depression. Data were analyzed using Statistical Package for Social Sciences SPSS, version 27.0.ResultsThe study found that the overall prevalence of probable depression was 42.8%. The study also found a relationship between alcohol consumption, lack of financial support, unplanned pregnancy, and probable depression in pregnant and parenting adolescents. The prevalence of unplanned pregnancy in the present study was 81.8%.ConclusionFurthermore, the present study indicated that participants from low socio-economic status families and those who were HIV positive were at a greater risk of depression in both groups. Therefore, we recommend that measures be put in place for early detection and treatment of depression and that social support be given to adolescent mothers.
Renal function at 12 months of kidney transplantation comparing tacrolimus and mycophenolate with tacrolimus and mTORi in donors with different KDPI ranges. A multicenter cohort study using propensity scoring
Authors: Rodrigues Arlisson Macedo , Tanno Mariana Tavares , Contti Mariana Moraes , Nga Hong Si , Valiatti Mariana Farina , Costa Silvana Daher , Sandes-Freitas Tainá Veras de , Esmeraldo Ronaldo de Matos , Assunção Camila Marinho , Tassi Juliana Bastos Campos , Ferreira Gustavo Fernandes , Felipe Claudia Rosso , Medina Pestana Jose Osmar , Silva Helio Tedesco , Andrade Luis Gustavo Modelli de 
Published: October 2023

IntroductionThe combination of tacrolimus/mTORi compared to tacrolimus/mycophenolate (MMF) was shown to be safe in the TRANSFORM trial. For donors with a high KDPI (Kidney Donor Profile Index), however, there are no data to support the effectiveness of this regimen. The main objective of this study was to explore the influence of the KDPI on 12-month renal function (eGFR) in patients receiving mTORi or MMF.MethodsMulticenter cohort study of four Brazilian services that use the tacrolimus with mTORi as a protocol. Data from 2008 to 2018 of the tacrolimus/mycophenolate (MMF) and tacrolimus/mTORi (mTORi) regimens in renal transplant recipients over 18 years old were collected. For better homogeneity, the propensity score was used. Afterward, the method used for group selection (“match”) was the K-nearest neighbor (KNN) method. New analyses were performed on this new balanced sample, and two different subsamples were constituted based on the median KDPI.ResultsThe global analysis (n = 870) showed that the major determinant of worse kidney function was high KDPI. Afterward, the three strata were analyzed. In the first stratum (KDPI up to 50), 242 patients were evaluated, with 121 in each group. The eGFR was 64 ml/min/1.73 m2 in the mTORi group compared to 63 in the MMF group, p = 0.4, and when imputed eGFR was evaluated, 61 in the mTORi and 53 in the MMF, p = 0.065. In the second stratum (KDPI from 50 to 85), 282 patients were evaluated, with 141 in each group. eGFR was 46 ml/min/1.73 m2 in mTORi compared to 48 in MMF, p = 0.4, and when imputed eGFR was evaluated, 40 mTORi and 41 MMF, p = 0.8. In the last stratum (KDPI higher than 85) with n = 126 and 63 cases per group, eGFR was 36 ml/min/1.73 m2 in mTORi compared to 39 in MMF, p = 0.2, and when imputed eGFR was evaluated, 30 mTORi and 34 MMF, p = 0.2.DiscussionThe regimen using mTOR inhibitor is an effective and safe regimen when compared to the standard regimen. In addition, the scheme seems to offer additional protection against infections and may be an important ally in cases of high risk for these pathologies.
Femoral neck fracture patients with ischaemic stroke choose hemiarthroplasty or constrained liner total hip arthroplasty? A retrospective comparative study of 199 cases
Authors: Huo Jia , Liu Sikai , Li Mengnan , Liu Zeming , Ding Xuzhuang , Liu Bo , Li Huijie , Han Yongtai 
Published: October 2023

BackgroundThe objective of this study was to assess the long-term survival rate, complications, as well as the clinical and radiological outcomes of hemiarthroplasty and total hip arthroplasty using constrained polyethylene liners in patients with ischemic stroke.MethodsThis study was a retrospective cohort study that included patients with ischemic stroke who underwent hip arthroplasty from March 2010 to September 2017. In the Constrained Acetabular Liners (CAL) group, patients received an uncemented acetabular shell with a constrained polyethylene liner. The Dual Mobility (DM) group underwent hemiarthroplasty (HA). Additionally, hip function, range of motion, quality of life, the incidence of clinical complications, and prosthesis stability were investigated.Results96 patients with unilateral femoral neck fractures who underwent hip replacement with CAL were included in the CAL group, while 103 patients who underwent hip replacement with a dual mobility head were included in the DM group. VAS, and SF-36 data were available for both CAL and DM groups. At the 1-year postoperative follow-up, the HHS in the CAL group was significantly lower than that in the DM group (80.83 ± 3.91 vs. 83.17 ± 4.15, P &lt; 0.05). The VAS score in the CAL group peaked at the 1-year follow-up (2.07 ± 0.91 vs. 1.49 ± 0.85, P &lt; 0.05). However, there were no significant differences between the two groups in terms of HSS, VAS, and SF-36 at the last follow-up after surgery. Operative time and the amount of bleeding in the DM group were significantly lower than those in the CAL group (105.30 ± 29.68 vs. 94.85 ± 31.07; 355.11 ± 123.95 vs. 302.22 ± 107.68, P &lt; 0.05). Additionally, there was no significant difference in the mean leg length discrepancy between the two groups.ConclusionThe clinical, imaging, and postoperative complications of the CAL and DM groups were analyzed. The prognosis for DM appears to be more beneficial for early patient recovery, but a higher likelihood of recurrent dislocation is observed. CAL offers excellent stability for primary THA in high-risk patients; however, attention should be given to preventing aseptic loosening.