bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in institution for mental diseases (IMD) ownership status and insurance acceptance over time
Authors: Hollander Mara A G , Patton Alexandra , Shields Morgan C 
Published: January 2024

AbstractState Medicaid programs are prohibited from using federal dollars to pay institutions for mental diseases (IMDs)—freestanding psychiatric facilities with more than 16 beds. Increasingly, regulatory mechanisms have made payment of treatment in these settings substantially more feasible. This study evaluates if changing financial incentives are associated with increases in for-profit ownership among IMD facilities relative to non-IMD facilities, as well as greater increases in Medicaid acceptance among for-profit IMD facilities relative to for-profit non-IMD facilities. We used data from the 2014–2020 National Mental Health Services Surveys and examined 11 945 facility-years. Relative to non-IMDs, the increase in for-profit ownership among IMDs was 6.6 percentage points greater. The largest proportional change in Medicaid acceptance occurred among for-profit IMD facilities relative to for-profit non-IMDs (18.5 percentage points). Existing research is mixed on the quality of inpatient and residential psychiatric care provided in for-profit vs nonprofit and public facilities, as well as in IMD relative to non-IMD facilities. As payment policy increasingly incentivizes for-profit facilities to enter the psychiatric care space, we should be mindful of the impact of these decisions on patient safety.
Lessons from Lyme Bay (UK) to inform policy, management, and monitoring of Marine Protected Areas
Authors: Renn Chloe , Rees Sian , Rees Adam , Davies Bede F R , Cartwright Amy Y , Fanshawe Sam , Attrill Martin J , Holmes Luke A , Sheehan Emma V 
Published: January 2024

Abstract
This decade represents a critical period to profoundly rethink human–nature interactions in order to address the interwoven climate and biodiversity crises. Marine Protected Areas (MPAs) demonstrate promise for increasing ecosystem resilience and reversing habitat and population declines, but outcomes vary considerably from context to context. Partially protected areas offer a compromise between ecological recovery and the social needs of local communities, but their success is contingent on an array of factors. This in-depth review summarizes 15 years of marine conservation research and impact in Lyme Bay (southwest UK), to serve as a model for the future adoption of partially protected MPAs. The findings from the UK’s longest integrated socioecological monitoring MPA study are presented and supplemented by an evaluation of the whole-site management approach as a core element of Lyme Bay’s achievements. The journey from research to improved monitoring and ambitious policy is illustrated within and interspersed with stories of novel discoveries, ongoing challenges, and method developments. What started as a dedicated group of community members has grown into an immense collaboration between fishers, scientists, NGOs, and regulators, and their combined efforts have sent ripple effects of positive change across the globe.
CdbC: a disulfide bond isomerase involved in the refolding of mycoloyltransferases in Corynebacterium glutamicum cells exposed to oxidative conditions
Authors: Jeong Haeri , Kim Younhee , Lee Heung-Shick 
Published: January 2024

Abstract
In Corynebacterium glutamicum cells, cdbC, which encodes a protein containing the CysXXCys motif, is regulated by the global redox-responsive regulator OsnR. In this study, we assessed the role of the periplasmic protein CdbC in disulfide bond formation and its involvement in mycomembrane biosynthesis. Purified CdbC efficiently refolded scrambled RNaseA, exhibiting prominent disulfide bond isomerase activity. The transcription of cdbC was decreased in cells grown in the presence of the reductant dithiothreitol (DTT). Moreover, unlike wild-type and cdbC-deleted cells, cdbC-overexpressing (P180-cdbC) cells grown in the presence of DTT exhibited retarded growth, abnormal cell morphology, increased cell surface hydrophobicity and altered mycolic acid composition. P180-cdbC cells cultured in a reducing environment accumulated trehalose monocorynomycolate, indicating mycomembrane deformation. Similarly, a two-hybrid analysis demonstrated the interaction of CdbC with the mycoloyltransferases MytA and MytB. Collectively, our findings suggest that CdbC, a periplasmic disulfide bond isomerase, refolds misfolded MytA and MytB and thereby assists in mycomembrane biosynthesis in cells exposed to oxidative conditions.
The ethics of influence in state-regulated schools: Tillson v. Rawls
Authors: Clayton Matthew 
Published: January 2024

Abstract
John Tillson’s Children, Religion and the Ethics of Influence develops and deploys the ‘epistemic criterion’ for deciding whether teachers should promote belief in particular propositions. He defends that criterion by arguing that it promotes human well-being and enables individuals to fulfil their duty to pursue the truth. In this article I draw on John Rawls’ conception of political liberalism to suggest that the epistemic criterion is an inappropriate basis for the political community’s shaping of children’s beliefs.
H i galaxy signatures in the SARAO MeerKAT Galactic Plane Survey – I. Probing the richness of the great attractor wall across the inner zone of avoidance
Authors: Steyn Nadia , Kraan-Korteweg Renée C , Rajohnson Sambatriniaina H A , Kurapati Sushma , Chen Hao , Frank Bradley , Serra Paolo , Staveley-Smith Lister , Camilo Fernando , Goedhart Sharmila 
Published: January 2024

ABSTRACT
This paper presents the first H i results extracted from the South African Radio Astronomy Observatory (SARAO) MeerKAT Galactic Plane Survey (SMGPS) – a narrow strip (Δb ∼ 3°) along the southern Milky Way. The primary goal consisted in tracing the great attractor (GA) wall across the innermost zone of avoidance. We reduced a segment spanning the longitude range 302° ≤ ℓ ≤ 332° for the redshift range z ≤ 0.08. The superb SMGPS sensitivity (rms = 0.3–0.5 mJy beam−1 per 44 km s−1 channel) and angular resolution (∼31″ × 26″) lead to a detection limit of log(MH i/M⊙) ≥ 8.5 at the GA distance ($\mbox{$V_{\rm {hel}}$}\, \sim 3500{\!-\!}6500$ km s−1). A total of 477 galaxy candidates were identified over the full redshift range. A comparison of the few H i detections with counterparts in the literature (mostly HIZOA) found the H i fluxes and other H i parameters to be highly consistent. The continuation of the GA wall is confirmed through a prominent overdensity of N = 214 detections in the GA distance range. At higher latitudes, the wall moves to higher redshifts, supportive of a possible link with the Ophiuchus cluster located behind the Galactic Bulge. This deep interferometric H i survey demonstrates the power of the SMGPS in improving our insight of large-scale structures at these extremely low latitudes, despite the high obscuration and continuum background.
You Say I Want a Revolution
Authors: Salkin Wendy 
Published: January 2024

Abstract
An underexamined insight of W. E. B. Du Bois’s John Brown is that John Brown worked for much of his life to cultivate democratic relationships with the Black Americans with and for whom he worked. Brown did so through practicing deference and deliberation, and by seeking authorization. However, Brown’s commitment to these practices faltered at a crucial moment in decision making: when he raided Harpers Ferry absent widespread support. Examining this aspect of John Brown brings into relief an overlooked tragic choice Brown made: To act in accordance with his own substantive vision of what justice required, Brown eschewed democratic ideals and practices that grounded the distinctive relations of equality he had cultivated with the Black communities with and for whom he worked.
Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression
Authors: Nitahara Kenta , Kawamura Atsuki , Kitamura Yuka , Kato Kiyoko , Namekawa Satoshi H , Nishiyama Masaaki 
Published: January 2024

Abstract
Meiosis is a key step during germ cell differentiation, accompanied by the activation of thousands of genes through germline-specific chromatin reorganization. The chromatin remodeling mechanisms underpinning early meiotic stages remain poorly understood. Here we focus on the function of one of the major autism genes, CHD8, in spermatogenesis, based on the epidemiological association between autism and low fertility rates. Specific ablation of Chd8 in germ cells results in gradual depletion of undifferentiated spermatogonia and the failure of meiotic double-strand break (DSB) formation, leading to meiotic prophase I arrest and cell death. Transcriptional analyses demonstrate that CHD8 is required for extensive activation of spermatogenic genes in spermatogonia, necessary for spermatogonial proliferation and meiosis. CHD8 directly binds and regulates genes crucial for meiosis, including H3K4me3 histone methyltransferase genes, meiotic cohesin genes, HORMA domain-containing genes, synaptonemal complex genes, and DNA damage response genes. We infer that CHD8 contributes to meiotic DSB formation and subsequent meiotic progression through combined regulation of these meiosis-related genes. Our study uncovers an essential role of CHD8 in the proliferation of undifferentiated spermatogonia and the successful progression of meiotic prophase I.
Categorizing Vaping Intensity Among Youth
Authors: Xie Catherine , Jeffers Abra M , Winickoff Jonathan P 
Published: January 2024

Abstract

Introduction
Increasing electronic cigarette use among youth has led to a need for a novel intensity measure of e-cigarette use and its association with nicotine addiction variables.

Aims and Methods
Using a cross-sectional study of the 2018–2019 PATH Wave 5 Youth survey, a new intensity metric of e-cigarette use, the average number of puffs per month as a function of frequency (days of use per month), number of uses per day and number of puffs per use, was developed for adolescent e-cigarette users. Using logistic regression, standard addiction measures were tested for association with higher quartile (Q) of e-cigarette intensity: Q1 (1–5 puffs), Q2 (6–50 puffs), Q3 (51–528 puffs), and Q4 (529 + puffs).

Results
Among 1051 current youth e-cigarette users, cravings were associated with greater intensity of use (Q2: aOR = 1.90, 95% CI: 0.94–3.87; Q3: aOR = 6.91, 95% CI: 3.25–14.69; and Q4: aOR = 21.48, 95% CI: 10.03–45.97). Craving associations exceeded the corresponding aORs for the identical regression using the frequency of use. Higher intensity was significantly associated with being an older adolescent (aOR = 1.85), best friend use (aOR: 3.35), not thinking about quitting (aOR: 2.51), and lower perceived addiction (aOR: 1.95).

Conclusions
This study found that an intensity metric (puffs per month) was strongly associated with cravings, best friend use, harm perception, and lack of intention to quit. This metric provides a more accurate picture of the intensity of youth e-cigarette use than other commonly used measures and may be important for understanding the current and future impact of the youth e-cigarette epidemic.

Implications
Adolescent addiction to e-cigarettes affects learning, memory, and attention. However, it is unknown whether the intensity of use, puffs per month, differs from frequency, days of use per month, and in relation to addiction measures. This study provides evidence that high-intensity use characterized by puffs per month has a stronger association with cravings compared to frequency, which suggests puffs per month may be a better measure of nicotine exposure. This new intensity metric may give insights into youth e-cigarette use patterns, addiction, and appropriate treatment of intense but intermittent users.
Progesterone Metabolism in Digitalis and Other Plants—60 Years of Research and Recent Results
Authors: Klein Jan 
Published: January 2024

Abstract
5β-Cardenolides are pharmaceutically important metabolites from the specialized metabolism of Digitalis lanata. They were used over decades to treat cardiac insufficiency and supraventricular tachycardia. Since the 1960s, plant scientists have known that progesterone is an essential precursor of cardenolide formation. Therefore, biosynthesis of plant progesterone was mainly analyzed in species of the cardenolide-containing genus Digitalis during the following decades. Today, Digitalis enzymes catalyzing the main steps of progesterone biosynthesis are known. Most of them are found in a broad range of organisms. This review will summarize the findings of 60 years of research on plant progesterone metabolism with particular focus on the recent results in Digitalis lanata and other plants.
PLEIOTROPIC REGULATORY LOCUS1 maintains actin microfilament integrity to regulate pavement cell morphogenesis
Authors: Gao Xiaowei , Yang Bo , Zhang Jingjing , Wang Chi , Ren Huibo , Fu Ying , Yang Zhenbiao 
Published: January 2024

Abstract
Actin dynamics are critical for plant cell morphogenesis, but the underlying signaling mechanisms regulating these dynamics are not well understood. Here, we established that PLEIOTROPIC REGULATORY LOCUS1 (PRL1) modulates leaf pavement cell (PC) morphogenesis in Arabidopsis (Arabidopsis thaliana) by maintaining the dynamic homeostasis of actin microfilaments (MF). Our previous studies indicated that PC shape was determined by antagonistic RHO-RELATED GTPase FROM PLANTS 2 (ROP2) and RHO-RELATED GTPase FROM PLANTS 6 (ROP6) signaling pathways that promote cortical MF and microtubule organization, respectively. Our genetic screen for additional components in ROP6-mediated signaling identified prl1 alleles. Genetic analysis confirmed that PRL1 plays a key role in PC morphogenesis. Mutations in PRL1 caused cortical MF depolymerization, resulting in defective PC morphogenesis. Further genetic analysis revealed that PRL1 is epistatic to ROP2 and ROP6 in PC morphogenesis. Mutations in PRL1 enhanced the effects of ROP2 and ROP6 in PC morphogenesis, leading to a synergistic phenotype in the PCs of ROP2 prl1 and ROP6 prl1. Furthermore, the activities of ROP2 and ROP6 were differentially altered in prl1 mutants, suggesting that ROP2 and ROP6 function downstream of PRL1. Additionally, cortical MF depolymerization in prl1 mutants occurred independently of ROP2 and ROP6, implying that these proteins impact PC morphogenesis in the prl1 mutant through other cellular processes. Our research indicates that PRL1 preserves the structural integrity of actin and facilitates pavement cell morphogenesis in Arabidopsis.
Automatic recording of rare behaviors of wild animals using video bio-loggers with on-board light-weight outlier detector
Authors: Tanigaki Kei , Otsuka Ryoma , Li Aiyi , Hatano Yota , Wei Yuanzhou , Koyama Shiho , Yoda Ken , Maekawa Takuya 
Published: January 2024

Abstract
Rare behaviors displayed by wild animals can generate new hypotheses; however, observing such behaviors may be challenging. While recent technological advancements, such as bio-loggers, may assist in documenting rare behaviors, the limited running time of battery-powered bio-loggers is insufficient to record rare behaviors when employing high-cost sensors (e.g. video cameras). In this study, we propose an artificial intelligence (AI)-enabled bio-logger that automatically detects outlier readings from always-on low-cost sensors, e.g. accelerometers, indicative of rare behaviors in target animals, without supervision by researchers, subsequently activating high-cost sensors to record only these behaviors. We implemented an on-board outlier detector via knowledge distillation by building a lightweight outlier classifier supervised by a high-cost outlier behavior detector trained in an unsupervised manner. The efficacy of AI bio-loggers has been demonstrated on seabirds, where videos and sensor data captured by the bio-loggers have enabled the identification of some rare behaviors, facilitating analyses of their frequency, and potential factors underlying these behaviors. This approach offers a means of documenting previously overlooked rare behaviors, augmenting our understanding of animal behavior.
Unexpected hydroxyl radical production in brewed tea under sunlight
Authors: Qin Linjun , Yang Lili , Shiraiwa Manabu , Faiola Francesco , Zhong Huan , Sonne Christian , Yang Yujue , Liu Shuting , Liu Guorui , Zheng Minghui , Jiang Guibin 
Published: January 2024

Abstract
Tea is one of the world's most popular and widely consumed beverages. It is a common pastime to enjoy a cup of tea in the sunshine. However, little attention has been given to understanding the possible photochemical reactions occurring beneath the calm surface of brewed tea. Epigallocatechin gallate (EGCG), which is widely used in food and beverages, is the most significant active ingredient found in tea. In this study, we investigated the presence of free radicals in both an aqueous EGCG solution and brewed tea under simulated sunlight conditions. To our surprise, we unexpectedly observed the production of hydroxyl radicals (•OH) in brewed tea. It was found that sunlight irradiation played a critical role in the formation of •OH, independent of the presence of metal ions. Furthermore, we demonstrated that the •OH generated from the EGCG aqueous solution induced cell cytotoxicity and DNA damage in vitro. Considering the crucial role of •OH in various fields, including human health and the environment, it is important to further explore the practical implications of •OH production in brewed tea under sunlight. In summary, our study unveils the unexpected formation of •OH in brewed tea and emphasizes the significance of sunlight-induced reactions. The observed cytotoxic and DNA-damaging effects of •OH emphasize the importance of understanding the potential health consequences associated with tea consumption. Further research in this area will contribute to a better understanding of the broader implications of •OH production in brewed tea under sunlight.
Simultaneous measurements of radon, thoron and thoron progeny and induced cancer risk assessment in Djeno, Pointe-Noire, Republic of Congo
Authors: Sondzo Jucit Sem , Dallou Guy Blanchard , Meye Philippe Ondo , Diahou Russel Rolphe Caroll Moubakou , Biona Clobite Bouka , Kranrod Chutima , Omori Yasutaka , Hosoda Masahiro , Saïdou  , Tokonami Shinji 
Published: January 2024

Abstract
In this study, the activity concentrations of radon (222Rn), thoron (220Rn) and thoron progeny were measured simultaneously in Djeno (Pointe-Noire, Republic of Congo) using RADUET detectors to evaluate the air quality and the radiological risks due to the inhalation of these radionuclides. Activity concentrations of radon progeny were calculated from those of radon. Indoor radon, thoron and progenies followed a lognormal distribution ranging between 20 and 40, 6 and 62, 8 and 17.6 and 0.4 and 19.6 Bq m−3 for radon, thoron, radon progeny and thoron progeny, respectively. Mean values for radon were lower than the worldwide values estimated by the United Nation Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), which are 40 Bq m−3 (arithmetic mean) and 45 Bq m−3 (geometric mean). Radon concentrations in the dwellings under study were below the World Health Organization and the International Commission on Radiological Protection recommended reference levels, which are, respectively, 100 and 300 Bq m−3. The mean concentration of thoron was twice the world average value of 10 Bq m−3 estimated by UNSCEAR. Thoron progeny mean concentration was sharply greater than the typical value (0.3 Bq m−3) for indoor atmosphere provided by UNSCEAR. Annual effective dose ranges were 0.40–0.87 mSv (arithmetic mean, 0.57 ± 0.11 mSv) for radon and 0.10–4.14 mSv (arithmetic mean, 0.55 ± 0.77 mSv) for thoron. The mean value for radon was lower than the value (1.15 mSv) estimated by UNSCEAR, while the mean value for thoron was five times higher than the UNSCEAR value (0.10 mSv). The study showed that the use of the typical equilibrium factor value given by UNSCEAR to compute effective dose led to an error above 80%. Finally, the results of this study showed that the excess relative risk of radon-induced cancer was low, below 2% for the population under 55 y. The results presented in the present study prove that the population of Djeno is exposed to a relatively low potential risk of radon- and thoron-induced cancer.
Multimodal neuroimaging correlates of spectral power in NREM sleep delta sub-bands in cognitively unimpaired older adults
Authors: Champetier Pierre , André Claire , Rehel Stéphane , Ourry Valentin , Landeau Brigitte , Mézenge Florence , Roquet Daniel , Vivien Denis , de La Sayette Vincent , Chételat Gaël , Rauchs Géraldine ,   the Medit-Ageing Research Group, Bejanin Alexandre , Chauveau Léa , Chocat Anne , Collette Fabienne , Dautricourt Sophie , De Flores Robin , Delarue Marion , Demnitz-King Harriet , Espérou Hélène , Fauvel Séverine , Felisatti Francesca , Ferrand Devouge Eglantine , Frison Eric , Gonneaud Julie , Haudry Sacha , Hébert Oriane , Klimecki Olga , Kuhn Elizabeth , Landeau Brigitte , Lefranc Valérie , Marchant Natalie , Mezenge Florence , Palix Cassandre , Quillard Anne , Requier Florence , Salmon Eric , Touron Edelweiss , Turpin Anne-Laure , Vuilleumier Patrik , Whitfield Tim , Wirth Miranka 
Published: January 2024

Abstract

Study Objectives
In aging, reduced delta power (0.5–4 Hz) during N2 and N3 sleep has been associated with gray matter (GM) atrophy and hypometabolism within frontal regions. Some studies have also reported associations between N2 and N3 sleep delta power in specific sub-bands and amyloid pathology. Our objective was to better understand the relationships between spectral power in delta sub-bands during N2–N3 sleep and brain integrity using multimodal neuroimaging.

Methods
In-home polysomnography was performed in 127 cognitively unimpaired older adults (mean age ± SD: 69.0 ± 3.8 years). N2–N3 sleep EEG power was calculated in delta (0.5–4 Hz), slow delta (0.5–1 Hz), and fast delta (1–4 Hz) frequency bands. Participants also underwent magnetic resonance imaging and Florbetapir-PET (early and late acquisitions) scans to assess GM volume, brain perfusion, and amyloid burden. Amyloid accumulation over ~21 months was also quantified.

Results
Higher delta power was associated with higher GM volume mainly in fronto-cingular regions. Specifically, slow delta power was positively correlated with GM volume and perfusion in these regions, while the inverse association was observed with fast delta power. Delta power was neither associated with amyloid burden at baseline nor its accumulation over time, whatever the frequency band considered.

Conclusions
Our results show that slow delta is particularly associated with preserved brain structure, and highlight the importance of analyzing delta power sub-bands to better understand the associations between delta power and brain integrity. Further longitudinal investigations with long follow-ups are needed to disentangle the associations among sleep, amyloid pathology, and dementia risk in older populations.

Clinical Trial Information
Name: Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training (Age-Well). URL: https://clinicaltrials.gov/ct2/show/NCT02977819?term=Age-Well&draw=2&rank=1. See STROBE_statement_AGEWELL in supplemental materials.

Registration
EudraCT: 2016-002441-36; IDRCB: 2016-A01767-44; ClinicalTrials.gov Identifier: NCT02977819.