bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of the role of Wasta social capital in enhancing employee loyalty and innovation in organizations
Authors: Al-Twal Arwa , Alawamleh Mohammad , Jarrar Doaa M. F. 
Published: February 2024

AbstractConsidering the pressures of fluctuating external environments, organizations are constantly seeking ways to be responsive and able to improve their performance with lower costs. Employer–employee relationships have changed rapidly in recent years, and there is growing interest in considering human resources as a form of capital, and a strategic factor for business excellence. A focal point for HR professionals is employee loyalty, recognized as pivotal in realizing long-term organizational goals. This paper delves into the concept of Wasta social capital and its pivotal role in fostering employee loyalty and innovation within the unique cultural context of the Arab world. It is argued here that Wasta social capital is the fundamental dynamic that stimulates employee loyalty in the workplace. This conceptual paper provides new insights through understanding the significant role Wasta social capital plays in affecting employee loyalty in a collectivist culture, differing from the conventional business-context factors of loyalty. Obtaining a deeper understanding of employee loyalty and how it is developed in Arab-world business contexts can promote innovation.
Assessing the association between triglyceride-glucose index and atrial fibrillation: a systematic review and meta-analysis
Authors: Azarboo Alireza , Behnoush Amir Hossein , Vaziri Zahra , Daneshvar Mohammad Shahabaddin , Taghvaei Aryan , Jalali Arash , Cannavo Alessandro , Khalaji Amirmohammad 
Published: February 2024

Abstract
Background
An essential relationship between insulin resistance (IR) and atrial fibrillation (AF) has been demonstrated. Among the methods used to assess IR, the triglyceride-glucose (TyG) index is the more straightforward, dimensionless, and low-cost tool. However, the possible usage of this index in clinical practice to predict and diagnose AF has yet to be determined and consolidated.

Objective and rationale
Herein, we performed a systematic review and meta-analysis to assess the association between the TyG index and AF.

Methods
Databases (PubMed, Embase, Scopus, and Web of Science) were systematically searched for studies evaluating the TyG index in AF. The inclusion criteria were observational studies investigating AF and TyG index correlation in individuals older than 18 years, while preclinical studies and those without the relevant data were excluded. Random effect meta-analyses comparing TyG levels between AF and non-AF cases, AF recurrence after radiofrequency ablation, and post-procedural AF were performed using standardized mean differences (SMD) with their matching 95% confidence intervals (CIs).

Results
Our screening identified nine studies to be analyzed, including 6,171 participants including 886 with AF. The meta-analysis demonstrated that the TyG index resulted higher in patients with AF than non-AF counterparts (SMD 1.23, 95% CI 0.71 to 1.75, I2 98%, P < 0.001). Subgroup analysis showed the same results for post-procedure AF (SMD 0.99, 95% CI 0.78 to 1.20, I2 10%, P < 0.001) and post-ablation AF (SMD 1.25, 95% CI 1.07 to 1.43, I2 46%, P < 0.001), while no difference was found in population-based cohorts (SMD 1.45, 95% CI − 0.41 to 3.31, I2 100%, P = 0.13). Publication year (P = 0.036) and sample size (P = 0.003) showed significant associations with the effect size, using multivariable meta-regression.

Conclusion
The TyG index is an easy-to-measure surrogate marker of IR in patients with AF. Further clinical studies are warranted to demonstrate its ability for routine clinical use and as a screening tool.
Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity
Authors: Behling Anna H. , Wilson Brooke C. , Ho Daniel , Cutfield Wayne S. , Vatanen Tommi , O’Sullivan Justin M. 
Published: February 2024

Abstract
Background
Horizontal gene transfer (HGT) describes the transmission of DNA outside of direct ancestral lineages. The process is best characterised within the bacterial kingdom and can enable the acquisition of genetic traits that support bacterial adaptation to novel niches. The adaptation of bacteria to novel niches has particular relevance for faecal microbiota transplantation (FMT), a therapeutic procedure which aims to resolve gut-related health conditions of individuals, through transplanted gut microbiota from healthy donors.

Results
Three hundred eighty-one stool metagenomic samples from a placebo-controlled FMT trial for obese adolescents (the Gut Bugs Trial) were analysed for HGT, using two complementary methodologies. First, all putative HGT events, including historical HGT signatures, were quantified using the bioinformatics application WAAFLE. Second, metagenomic assembly and gene clustering were used to assess and quantify donor-specific genes transferred to recipients following the intervention. Both methodologies found no difference between the level of putative HGT events in the gut microbiomes of FMT and placebo recipients, post-intervention. HGT events facilitated by engrafted donor species in the FMT recipient gut at 6 weeks post-intervention were identified and characterised. Bacterial strains contributing to this subset of HGT events predominantly belonged to the phylum Bacteroidetes. Engraftment-dependent horizontally transferred genes were retained within recipient microbiomes at 12 and 26 weeks post-intervention.

Conclusion
Our study suggests that novel microorganisms introduced into the recipient gut following FMT have no impact on the basal rate of HGT within the human gut microbiome. Analyses of further FMT studies are required to assess the generalisability of this conclusion across different FMT study designs and for the treatment of different gut-related conditions.
Altered expression of serum lncRNA CASC2 and miRNA-21-5p in COVID-19 patients
Authors: Ayoub Shymaa E. , Shaker Olfat G. , Masoud Mohamed , Hassan Essam A. , Ezzat Eman M. , Ahmed Mona I. , Ahmed Randa I. , Amin Amal A. Ibrahim , Abd El Reheem Fadwa , Khalefa Abeer A. , Mahmoud Rania H. 
Published: February 2024

AbstractInfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has a high incidence of spread. On January 30, 2020, the World Health Organization proclaimed a public health emergency of worldwide concern. More than 6.9 million deaths and more than 768 million confirmed cases had been reported worldwide as of June 18, 2023. This study included 51 patients and 50 age- and sex-matched healthy subjects. The present study aimed to identify the expression levels of lncRNA CASC2 and miRNA-21-5p (also known as miRNA-21) in COVID-19 patients and their relation to the clinicopathological characteristics of the disease. The expression levels of noncoding RNAs were measured by RT-PCR technique. Results detected that CASC2 was significantly downregulated while miRNA-21-5p was significantly upregulated in COVID-19 patients compared to healthy subjects. A significant negative correlation was found between CASC2 and miRNA-21-5p. ROC curve analysis used to distinguish COVID-19 patients from controls. MiRNA-21-p serum expression level had a significant positive association with temperature and PO2 (p = 0.04 for each). These findings indicate that CASC2 and miRNA-21-p might be used as potential diagnostic and therapeutic biomarkers in COVID-19.
3D mechanical analysis of geothermal reservoir operations in faulted sedimentary aquifers using MACRIS
Authors: Marelis Arjan , Beekman Fred , van Wees Jan-Diederik 
Published: February 2024

AbstractAccurate and efficient predictions of three-dimensional subsurface stress changes are required for the assessment of geothermal operations with respect to fault stability and the potential risk for induced seismicity. This work extends the model capabilities of Mechanical Analysis of Complex Reservoirs for Induced Seismicity (MACRIS) to account for high-resolution thermo-elastic stress evaluations in structurally complex (i.e. faulted) and matrix permeability dominated geothermal systems. By adopting a mesh-free approach suitable to industry standard flow simulation models, MACRIS is capable of preserving the complex 3D hydraulic development of the injected cold-water volume and the 3D geometrical complexities of the reservoir model. The workflow has been applied to three-dimensional models with clastic reservoir characteristics representative for low enthalpy geothermal exploitation in the Netherlands. The models are marked by a single fault, subject to no and normal offset. Comparison of simulated stress evolutions in MACRIS with alternative analytical solutions highlight the effects of stress arching involved in the poro- and thermo-elastic stress developments on complex faults intersected by or in direct contact with the cold-water volume. Results are in agreement with previous studies and show the effect of thermal stressing to be dominant, arching of stresses to occur at the rim of the cold-water volume, and in cooling reservoirs, the intersection area of the cold-water volume in direct contact with the fault plane to be the main driver for fault reactivation and subsequent seismic potential. Moreover, results show the effects of stress arching (i) to be enhanced in the case of reservoir throw and flow compartmentalization, and (ii) to be reduced by a relative increase in conductive heat transfer between the reservoir and surrounding formations.
HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study
Authors: Lilien Thijs A. , Fenn Dominic W. , Brinkman Paul , Hagens Laura A. , Smit Marry R. , Heijnen Nanon F. L. , van Woensel Job B. M. , Bos Lieuwe D. J. , Bem Reinout A. ,   the DARTS study group, Verschueren Alwin R. M. , Nijsen Tamara M. E. , Geven Inge , Presură Cristian N. , Rietman Ronald , Schultz Marcus J. , Bergmans Dennis C. J. J. , Schnabel Ronny M. 
Published: February 2024

Abstract
Background
Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identified VOCs and concerns about their precise pathophysiological origins warrant translational studies assessing their validity as a marker of hyperoxia-induced oxidative stress. Therefore, this study sought to examine changes in VOCs previously associated with the oxidative stress response in hyperoxia-exposed lung epithelial cells.

Methods
A549 alveolar epithelial cells were exposed to hyperoxia for 24 h, or to room air as normoxia controls, or hydrogen peroxide as oxidative-stress positive controls. VOCs were sampled from the headspace, analysed by gas chromatography coupled with mass spectrometry and compared by targeted and untargeted analyses. A secondary analysis of breath samples from a large cohort of critically ill adult patients assessed the association of identified VOCs with clinical oxygen exposure.

Results
Following cellular hyperoxia exposure, none of the targeted VOCs, previously proposed as breath markers of oxidative stress, were increased, and decane was significantly decreased. Untargeted analysis did not reveal novel identifiable hyperoxia-associated VOCs. Within the clinical cohort, three previously proposed breath markers of oxidative stress, hexane, octane, and decane had no real diagnostic value in discriminating patients exposed to hyperoxia.

Conclusions
Hyperoxia exposure of alveolar epithelial cells did not result in an increase in identifiable VOCs, whilst VOCs previously linked to oxidative stress were not associated with oxygen exposure in a cohort of critically ill patients. These findings suggest that the pathophysiological origin of previously proposed breath markers of oxidative stress is more complex than just oxidative stress from hyperoxia at the lung epithelial cellular level.
Using tumor habitat-derived radiomic analysis during pretreatment 18F-FDG PET for predicting KRAS/NRAS/BRAF mutations in colorectal cancer
Authors: Zhao Hongyue , Su Yexin , Wang Yan , Lyu Zhehao , Xu Peng , Gu Wenchao , Tian Lin , Fu Peng 
Published: February 2024

Abstract
Background
To investigate the association between Kirsten rat sarcoma viral oncogene homolog (KRAS) / neuroblastoma rat sarcoma viral oncogene homolog (NRAS) /v-raf murine sarcoma viral oncogene homolog B (BRAF) mutations and the tumor habitat-derived radiomic features obtained during pretreatment 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with colorectal cancer (CRC).

Methods
We retrospectively enrolled 62 patients with CRC who had undergone 18F-FDG PET/computed tomography from January 2017 to July 2022 before the initiation of therapy. The patients were randomly split into training and validation cohorts with a ratio of 6:4. The whole tumor region radiomic features, habitat-derived radiomic features, and metabolic parameters were extracted from 18F-FDG PET images. After reducing the feature dimension and selecting meaningful features, we constructed a hierarchical model of KRAS/NRAS/BRAF mutations by using the support vector machine. The convergence of the model was evaluated by using learning curve, and its performance was assessed based on the area under the receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis. The SHapley Additive exPlanation was used to interpret the contributions of various features to predictions of the model.

Results
The model constructed by using habitat-derived radiomic features had adequate predictive power with respect to KRAS/NRAS/BRAF mutations, with an AUC of 0.759 (95% CI: 0.585–0.909) on the training cohort and that of 0.701 (95% CI: 0.468–0.916) on the validation cohort. The model exhibited good convergence, suitable calibration, and clinical application value. The results of the SHapley Additive explanation showed that the peritumoral habitat and a high_metabolism habitat had the greatest impact on predictions of the model. No meaningful whole tumor region radiomic features or metabolic parameters were retained during feature selection.

Conclusion
The habitat-derived radiomic features were found to be helpful in stratifying the status of KRAS/NRAS/BRAF in CRC patients. The approach proposed here has significant implications for adjuvant treatment decisions in patients with CRC, and needs to be further validated on a larger prospective cohort.
Impact of the combination and replacement of SLR-based low-degree gravity field coefficients in GRACE solutions
Authors: Gałdyn Filip , Sośnica Krzysztof 
Published: February 2024

AbstractGRACE and GRACE Follow-On (FO) missions provide time-variable gravity field models of unprecedented quality that allow for the hydrological, oceanic, and ice mass change studies on a global scale. However, the very low-degree coefficients derived from GRACE and GRACE-FO are of inferior quality due to thermal effects acting on satellites and malfunctioning of the onboard accelerometers. Therefore, C20 and C30 coefficients describing the Earth’s oblateness and the pear shape of the Earth, respectively, are being replaced by values derived from satellite laser ranging (SLR) in the standard GRACE solutions. This study assesses the impact of the replacement of low-degree gravity field coefficients in GRACE/GRACE-FO solutions by SLR data on the trend and seasonal signals of ice mass changes in Greenland and Antarctica. We found that the replacement of the low-degree gravity field coefficients changes the estimates of trends by 4, 8, and 22 Gt/year in Greenland, West, and East Antarctica, respectively, depending on the source of SLR coefficients and period for which the coefficients are replaced. In SLR and GRACE solutions, all coefficients of the same order and the same parity of degrees are strongly correlated. Therefore, replacing only two selected coefficients may lead to a biased solution. Thus, we propose to combine GRACE with SLR solutions up to a degree and order 10 × 10 to properly consider the sensitivity of each of the techniques to gravity field coefficients, instead of replacing two coefficients from SLR in GRACE solutions. The combined solution reduces the residual trend of post-glacial rebound from 1.2 to 0.9 Gt/year and from − 57.8 to − 57.0 Gt/year in Scandinavia and South Canada, respectively, when compared to GRACE/GRACE-FO solutions with the replacement of coefficients. The SLR-GRACE combination reduces the noise in the GRACE/GRACE-FO solutions by 8%, from 38 to 35 Gt, in the Fennoscandia region. In the periods when GRACE is at the end of its mission and observations are disrupted, the weights adjust the contribution from SLR and GRACE based on relative ratio of variances from each techniques. Thus, the combined solutions are more consistent with independent geophysical models of glacial isostatic adjustment, and the combinations are affected by smaller noise than the standard GRACE solutions and properly account for different sensitivities of SLR and GRACE techniques to low-degree time-variable gravity field coefficients.
Methane genesis within olivine-hosted fluid inclusions in dolomitic marble of the Hida Belt, Japan
Authors: Harada Hironobu , Tsujimori Tatsuki 
Published: February 2024

AbstractAbiotic synthesis of hydrocarbon-bearing fluids during geological processes has a significant impact on the evolution of both the Earth's biosphere and the solid Earth. Aqueous alteration of ultramafic rocks, i.e., serpentinization, which forms serpentinite, is one of the geological processes generating abiotic methane (CH4). However, abiotic CH4 generation is not limited to the serpentinization of mafic and ultramafic lithologies. Metasedimentary dolomitic marble from the Hida Belt, Japan, is characterized by the presence of forsterite-rich olivine (Fo~89–93), and olivine crystals contain abundant fluid inclusions (<1 to 10 μm in size). Raman spectroscopic analyses of olivine-hosted fluid inclusions found that both primary and secondary fluid inclusions contain CH4, lizardite/chrysotile, and brucite. This indicates that micro-scale interactions between COH fluid and host olivine produced CH4 through the reduction of CO2 by H2 released during local serpentinization within inclusions. Our observation implies that the dolomitic marble has the potential to be a key lithology for the synthesis and storage of abiotic CH4 in a shallower crustal portion of orogenic belts.
Evaluation of dietary composition between hemoglobin categories, total body iron content and adherence to multi-micronutrients in preschooler residents of the highlands of Puno, Peru
Authors: Choque-Quispe Benita Maritza , Vásquez-Velásquez Cinthya , Gonzales Gustavo F. 
Published: February 2024

Abstract
Background
The anemia prevalence is higher in highlands populations. It is assumed that iron deficiency anemia (IDA) in children is mainly due to low dietary intake. However, other suggest that high prevalence of anemia is due to an inappropriate hemoglobin (Hb) adjustment for altitude.

Materials and methods
Cross-sectional study conducted in 338 preschoolers (PSC) from Puno-Peru. Hb was measured in whole blood, and ferritin, Soluble transferrin receptor, and Interleukin 6 in serum.The dietary iron intake was assessed by 24-h dietary recall, using NutriCap Software. Hb concentration was assessed as adjusted or unadjusted for altitude.

Results
With unadjusted Hb, the anemia prevalence was 4.7%, whereas after Hb correction, the prevalence raised-up to 65.6% (p < 0.001). Reciprocally, erythrocytosis proportion decreased from 20.35 to 0.30% (p < 0.001). Total Body Iron (TBI) showed that 7.44% had ID and 0.32% had IDA. PSC with normal unadjusted Hb levels have more protein and micronutrients intake than anemic ones. PSC with erythrocytosis consumed less fat, and more niacin and ascorbic acid than anemics. Total iron intake was lower in anemic than the other groups, but without statistical significance due to the standard deviation of the data in a small number of anemic PSC (n = 16). TBI, unadjusted Hb, and adjusted Hb were not different between groups consuming or not multimicronutrients.

Conclusions
The consumption of iron and iron status in children who live at high altitude is adequate, and that anemia could be due to other micronutrient deficiencies and/or that the adjustment of Hb by altitude is inappropriate.
Towards a precise and reflexive use of migration-related terminology in quantitative research: criticism and suggestions
Authors: Borrelli Lisa Marie , Ruedin Didier 
Published: February 2024

AbstractTo describe migration-related phenomena, we need to reflect on the terminology and choose the most adequate one that allows us to determine whether migration is the (main) cause of a phenomenon, a consequence, or even unrelated and misattributed. We argue that the use of such terminology in quantitative and experimental research is often flawed because of its differentiated adoption in legal, political, or scientific contexts. To illustrate our argument, we focus on two commonly used terms, ‘second generation’ and ‘migration background’ to show that in many situations these terms do not accurately describe the population we study. In part, the terms imply a false homogeneity, focus on deficits, and perpetuate differences regarding national belonging where there may be structural reasons and other aspects, such as social class, that lie at the heart of observed differences. With a particular focus on quantitative research, we use survey evidence and a principled literature search, to show that both researchers and the general population often identify immigrants in terms of ethnic origin — even though the term has its own pitfalls. We conclude that quantitative research should avoid reproducing state-created terminology and instead look beyond the strict field of immigration to consider other systems of classification like gender, ethnicity, language, or social class to reduce the negative attributes ascribed to non-citizens.