bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІНКЛЮЗИВНО-РЕСУРСНІ ЦЕНТРИ В УМОВАХ ВІЙНИ: ОКРЕМІ ПИТАННЯ ОСВІТИ ДІТЕЙ З ОСОБЛИВИМИ ПОТРЕБАМИ
Authors: Прохоренко Леся 
Published: October 2023

У статті теоретично обґрунтовано основні проблеми в освіті осіб з особливими освітніми потребами (ООП) в умовах воєнного стану. Проаналізовано підходи доступності і дитиноцентризму, які є ключовими у моделі освіти України, що передбачають такі характеристики якості, як рівний доступ до навчання, ефективний навчальний процес, безпечне і здорове навчальне середовище; участь усіх учасників навчального процесу у шкільному менеджменті; багаторівнева громадська взаємодія тощо. Зазначено, що рівноправний доступ до якісної освіти, у тому числі осіб з особливими потребами, є міжнародною програмою, в якій запропоновано п’ять вимірів освітньої якості: ефективність, продуктивність, рівність і відповідність (вимогам учнів, їх сімей і вимогам суспільства). В Україні на цьому шляху здійснено чимало змін як на рівні законодавства, так і на рівні практики: внесені зміни в основні Закони України про розвиток і впровадження інклюзивної освіти; створені умови для навчання дітей і молоді з особливими освітніми потребами на базі багатьох дошкільних, загальноосвітніх і вищих навчальних закладів, розвинуто мережу інклюзивно-ресурсних центрів, які визначають для осіб з особливими потребами індивідуальний освітній вектор в умовах інклюзивного освітнього середовища тощо. Обґрунтовано сучасний практичний досвід функціонування ІРЦ в умовах війни, що зумовлює потребу у проведенні емпіричних розвідок, узагальненні результатів, а також визначенні тих умов діяльності ІРЦ, дефіцит яких негативно впливає на весь процес супроводження осіб з особливими потребами. Зокрема, йдеться про: розроблення інноваційних підходів до системного кваліфікованого супроводу та надання психолого-педагогічних і корекційно-розвивальних послуг особам з особливими освітніми потребами в умовах війни та повоєнного відродження; удосконалення нормативно-правового, методичного, кадрового забезпечення інклюзивно-ресурсних центрів; оновлення психолого-педагогічних і корекційно-розвивальних послуг у територіальних громадах, які є необхідними для дітей з особливими освітніми потребами та їх сімей, у тому числі внутрішньо переміщених.Окреслено коло проблемних питань, які потребують вирішення, зокрема, брак ресурсів, досвіду, розуміння основних переваг нової філософії освіти; створення адекватних умов для дітей з різними рівнями освітніх труднощів у навчанні (в тому числі для осіб з різних національних меншин та обдарованих).
Mortality rate and factors associated with mortality of carbapenem-resistant Enterobacteriaceae infection
Authors: So-ngern Apichart , Osaithai Naphol , Meesing Atibordee , Chumpangern Worawat 
Published: October 2023

Background: Carbapenem-resistant Enterobacteriaceae (CRE) is a serious pathogen with high mortality. Recognition of factors associated with mortality and treating these modifiable factors are crucial to reducing mortality.Objective: To determine the 30-day mortality and factors associated with a 30-day mortality of CRE infection.Methods: A retrospective cohort study was conducted between January 1, 2015, and December 31, 2019. All patients diagnosed with CRE infection aged ≥18 years were included. Multivariate logistic regression was used for evaluating the factors associated with 30-day mortality and presented as adjusted odds ratio (aOR) with 95% confidence interval (CI).Result: One hundred and ninety-four patients were enrolled. The 30-day mortality occurred in 75 patients (38.7%). The common antibiotic regimen was monotherapy and combination of carbapenem, colistin, amikacin, tigecycline, and fosfomycin. CRE isolates were susceptible to tigecycline (93.8%), colistin (91.8%), fosfomycin (89.2%), and amikacin (89.2%). The independent factors associated with 30-day mortality were an increasing simplified acute physiology (SAP) II score (aOR 1.11, 95% CI 1.05-1.16, p < 0.001), sepsis at time of CRE infection diagnosis (aOR 7.93, 95% CI 2.21-28.51, p = 0.002), pneumonia (aOR 4.48, 95% CI 1.61-12.44, p = 0.004), monotherapy (aOR 4.69, 95% CI 1.71-12.85, p = 0.003), and improper empiric antibiotic (aOR 5.13, 95% CI 1.83-14.40, p = 0.002).Conclusion: The overall 30-day mortality of CRE infection was high. The factors associated with mortality were an increasing SAP II score, sepsis at time of CRE infection diagnosis, pneumonia, monotherapy, and improper empiric antibiotic. The study suggested that proper empiric antibiotic and combination antibiotics might reduce mortality from CRE infection.
IDENTIFIKASI SEKTOR UNGGULAN DALAM MENINGKATKAN EKONOMI DAERAH DI KABUPATEN BANYUMAS
Authors: Pangestika Maulida Dewi 
Published: October 2023

Abstract.
Identification of leading sectors in banyumas regency is one of the means to develop economy according to its potential. This is opportunity for the region to employ natural resources. However, there is a decentralization policy haven’t been able to improve economy. Its indicated by the high regional inequality even though the source of financing has been fully managed by the local government. This study purpose to determine the superior sector of banyumas regency. The study uses secondary data sources from the central statistics agency in the 2018-2022. The analysis used includes location quentiont (LQ), shift share (SS), and Tipology Klassen. The results showed that Banyumas regency had a shift in leading sectors with prime categories sectors including industrial processing, construction, information and communication. While, potential conditions including retail trade, agriculture.
Keyword: leading sector, gross domestic bruto, fiscal decentralization
Abstraksi.
Identifikasi sektor unggulan pada kabupaten banyumas merupakan salah satu upaya dalam mengembangkan ekonomi sesuai dengan potensi yang dimiliki. Hal tersebut menjadi peluang bagi wilayah dalam memanfaatkan sumber daya alam. Namun adanya kebijakan desentralisasi fiskal ternyata belum mampu memaksimalkan perekonomian. Hal ini ditunjukkan dengan tingginya ketimpangan wilayah walaupun sumber pendanaan sepenuhnya telah dikelola oleh pemerintah daerah. Penelitian ini bertujuan unuk mengetahui sektor unggulan kabupaten banyumas. Penelitian ini menggunakan sumber data sekunder dari badan pusat statistik pada rentan waktu tahun 2018-2022. Analisis yang digunakan antara lain Location Quentiont, Shift Share, dan tipologi klassen. Hasil penelitian didapat bahwa kabupaten banyumas memiliki pergeseran sektor unggulan dengan kategori prima atau perekonomian cepat antara lain industri pengolahan, konstruksi,dam informasi dan komunikasi, sedangkan kondisi potensial yaitu perdagangan besar dan eceran serta pertanian, pertenak, dan perikanan.
Kata kunci: sektor unggulan, produk domestik regional bruto, desentralisasi fiskal
RPP BERBASIS MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERDASARKAN PROSEDUR PENGEMBANGAN ADDIE
Authors: Emylda Kusuma Trisna Wati  , Nur Kuswanti  , Noer Afâ€™idah  
Published: October 2023

Abstract: The effectiveness and achievement of learning objectives are determined by the educators. Educators must design lesson plans before learning activities take place. This study aims to develop lesson plans based on cooperative learning model type STAD, quality excretion system material based on the level of validity. This development uses ADDIE (analysis, design, development, application, and evaluation). However, due to constrained conditions during the Covid-19 epidemic, the implementation stage was not carried out. The data collection method used lesson plan validation sheet. The data were obtained through a validity test. The results of the validity test in the form of lesson plans developed are classified as valid with an average value of 4.5 so that they are suitable to be used in learning.
Keywords: Lesson Plans, Cooperative Learning, STAD

Abstrak: Efektifitas dan tercapainya tujuan pembelajaran ditentukan oleh pendidik. Pendidik harus merancang RPP sebelum kegiatan pembelajaran berlangsung. Penelitian ini bertujuan mengembangkan RPP berbasis model pembelajaran kooperatif Tipe STAD materi sistem ekskresi yang berkualitas berdasarkan tingkat kevalidan. Pengembangan ini menggunakan ADDIE (analisis, perancangan, pengembangan, penerapan, dan evaluasi). Akan tetapi, dikarenakan terkendalanya kondisi pandemi covid-19, tahap penerapan tidak dilakukan. Metode pengumpulan data menggunakan lembar validasi RPP. Perolehan data dilakukan uji validitas. Hasil uji validitas berupa RPP yang dikembangkan tergolong valid dengan nilai rata-rata 4,5 sehingga layak untuk digunakan dalam pembelajaran.
Kata kunci: RPP, Pembelajaran Kooperatif, STAD
Insights into the reactivity and lithium plating mechanisms of ultra-thin metal oxide coatings for anode-free solid-state lithium metal batteries
Authors: Counihan Michael J. , Kim Taewoo , Pathak Rajesh , Zagorac Teodora , Yang Yingjie , Burns Meghan E. , Cabana Jordi , Klie Robert F. , Hanley Luke , Connell Justin G. , Mane Anil U. , Elam Jeffrey W. , Tepavcevic Sanja 
Published: October 2023

Solid-state batteries (SSBs) in an “anode-free” cell format using lithium metal anodes are the best candidates for high energy density battery applications. However, low lithium metal Coulombic efficiency and charge loss due to solid electrolyte interphase (SEI) formation severely limit the cycle life of anode-free SSBs. Here, we explore ultra-thin (5–20 nm) Al2O3 and ZnO coatings deposited by atomic layer deposition (ALD) on copper electrodes for anode-free cells with a solid polymer electrolyte. Voltammetry shows that lithium inventory loss from SEI formation is reduced over 50% with Al2O3@Cu electrodes, but these electrodes experience orders of magnitude higher interface resistances than bare Cu and ZnO@Cu electrodes due to low ionic and electronic conductivities. The electrochemical differences are reflected in XPS, where Al2O3 undergoes a self-limiting lithiation reaction with Li0, while ZnO reacts completely with Li0 to form LiZn and Li2O. These chemical differences result in higher and lower lithium plating nucleation overpotentials for Al2O3 (up to 220 mV) and ZnO (down to 15 mV) coatings, respectively, relative to uncoated Cu electrodes (35 mV). ToF-SIMS reveals lithium plating underneath a LiyAlOx coating and through emergent defects and pinholes with Al2O3@Cu electrodes, while it plates exclusively on top of converted ZnO@Cu electrodes. SEM corroborates these mechanisms, showing sparse coverage of isolated Li clusters plated with Al2O3@Cu electrodes, while Cu and ZnO@Cu grow more dense and interconnected deposits. Despite both coatings improving different aspects of anode-free battery design, unmodified Cu electrodes show higher Coulombic efficiencies (∼77%) than Al2O3@Cu (up to 70%) and ZnO@Cu (up to 75%) electrodes. Increasing Al2O3 thickness decreases the practical current density compared to unmodified Cu (30 µA/cm2), but increasing ZnO thicknesses can double or triple this value. These (electro)chemical and morphological observations suggest two mechanisms: less-reactive metal oxides develop lithium ion conductivity through their structure to plate lithium underneath, while more-reactive metal oxides undergo full reduction and conversion with lithium plating above the coating. This fundamental research opens future work to leverage these mechanisms and explore other materials for high-efficiency anode-free SSBs.
Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties
Authors: Hamrangsekachaee Mohammad , Wen Ke , Yazdani Narges , Willits Rebecca K. , Bencherif Sidi A. , Ebong Eno E. 
Published: October 2023

Glycocalyx (GCX) is a carbohydrate-rich structure that coats the surface of endothelial cells (ECs) and lines the blood vessel lumen. Mechanical perturbations in the vascular environment, such as blood vessel stiffness, can be transduced and sent to ECs through mechanosensors such as GCX. Adverse stiffness alters GCX-mediated mechanotransduction and leads to EC dysfunction and eventually atherosclerotic cardiovascular diseases. To understand GCX-regulated mechanotransduction events, an in vitro model emulating in vivo vessel conditions is needed. To this end, we investigated the impact of matrix chemical and mechanical properties on GCX expression via fabricating a tunable non-swelling matrix based on the collagen-derived polypeptide, gelatin. To study the effect of matrix composition, we conducted a comparative analysis of GCX expression using different concentrations (60–25,000 μg/mL) of gelatin and gelatin methacrylate (GelMA) in comparison to fibronectin (60 μg/mL), a standard coating material for GCX-related studies. Using immunocytochemistry analysis, we showed for the first time that different substrate compositions and concentrations altered the overall GCX expression on human umbilical vein ECs (HUVECs). Subsequently, GelMA hydrogels were fabricated with stiffnesses of 2.5 and 5 kPa, representing healthy vessel tissues, and 10 kPa, corresponding to diseased vessel tissues. Immunocytochemistry analysis showed that on hydrogels with different levels of stiffness, the GCX expression in HUVECs remained unchanged, while its major polysaccharide components exhibited dysregulation in distinct patterns. For example, there was a significant decrease in heparan sulfate expression on pathological substrates (10 kPa), while sialic acid expression increased with increased matrix stiffness. This study suggests the specific mechanisms through which GCX may influence ECs in modulating barrier function, immune cell adhesion, and mechanotransduction function under distinct chemical and mechanical conditions of both healthy and diseased substrates.
Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 years
Authors: Sugita Yousuke , Ito Katsuhiko , Yoshioka Yui , Kudo Ayano , Arakawa Sota , Sakai Satoshi 
Published: October 2023

IntroductionExercise training is an established intervention method for improving exercise capacity and survival rates in patients with heart failure with preserved ejection fraction (HFpEF). However, most reports have focused on European and American patients, with limited data regarding the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in East Asian patients. This study investigated the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in Japanese patients aged 65–80 years with HFpEF.MethodsThis single-center, open-label, non-randomized, controlled trial prospectively enrolled 99 outpatients. Eligibility criteria for HFpEF patients were an HFA score ≥5 in addition to clinical symptoms of heart failure and left ventricular diastolic dysfunction. Exercise training in the intervention group consisted of aerobic exercise and strength training thrice weekly for 5 months. Patients in the control group continued the usual treatment for 5 months. Resting cardiac function was evaluated using echocardiography. Peak oxygen uptake (peakVO2), ventilatory equivalent (VE) vs. carbon dioxide output (VCO2) slope, peak cardiac output index, and arteriovenous oxygen difference were calculated using cardiopulmonary exercise testing combined with impedance cardiography.ResultsAfter 5 months of exercise training, remarkable interactions were observed, with peakVO2 as the primary outcome. Additionally, significant interactions were observed between hemodynamic indices and some echocardiographic parameters. The mean percentage change in peakVO2 from baseline was 8.3% in the intervention group. Fifteen study participants (30.1%) in the intervention group achieved a clinically meaningful change of 3.0 ml/min/kg (10% improvement) in peakVO2 from baseline. The group with 3.0 ml/min/kg or 10% improvement in peakVO2 from baseline had a considerably lower prevalence of diabetes mellitus and VE vs. VCO2 slope and considerably higher left atrial-global longitudinal strain values than the group without any notable improvements.ConclusionsAlthough exercise training can help improve exercise intolerance in Japanese patients aged 65–80 years with HFpEF, its benefits are limited. Our results suggest that HFpEF, complicated by diabetes mellitus and decreased ventilatory efficiency during exercise, may require reconsideration of intervention strategies. This trial was registered with the University Hospital Medical Information Network, a trial registry in Japan (registration number: UMIN000045474).
Perioperative hormone level changes and their clinical implications in patients with pituitary adenoma: a retrospective study of 428 cases at a single center
Authors: Zhao Min , Li Kai , Niu Hongchuan , Zhao Yuanli , Lu Changyu 
Published: October 2023

ObjectiveThis study employs case data analysis to elucidate alterations in hormone levels pre and post-surgery among patients with pituitary adenoma. Moreover, it investigates the influence of various associated factors on endocrine function.MethodsA retrospective analysis was conducted on clinical data from 428 patients who underwent surgical treatment within a short period at a single center. Statistical methods were employed to examine detailed hormone level fluctuations before and after surgery in patients with pituitary adenoma, along with their interrelations with different factors.ResultsBetween January 2016 and October 2022, a total of 428 consecutive patients with pituitary adenoma underwent surgical treatment. Of these, 232 were males and 196 were females, with an average age of 45.91 years (range: 16-84, standard deviation: 12.18). Univariate analysis indicated that females exhibited a higher susceptibility to preoperative endocrine dysfunction (p &lt; 0.05). Conversely, males, patients with larger tumor volumes, and older patients were more prone to preoperative pituitary insufficiency. Postoperatively, the most substantial remission rate occurred in prolactin (77.4%), followed by growth hormone (GH) (71.8%) and cortisol (4/6). The highest recovery rate in functions was observed in growth hormone secretion function (80%), followed by pituitary-adrenal axis hormone secretion function (56.3%) and pituitary-thyroid axis hormone secretion function (47.5%). The most noteworthy incidence of newly developed postoperative endocrine deficiencies was found in the pituitary-adrenal axis (31.8%), while the occurrence rates of deficiencies in other axes were relatively low. The elevated postoperative remission rate of growth hormone correlated with a higher surgical resection rate and lower preoperative growth hormone levels. Additionally, lower preoperative prolactin levels corresponded to a higher remission rate of prolactin postoperatively. Furthermore, the restoration of postoperative thyroid hormone secretion function was associated with higher preoperative free thyroxine levels. Reduced postoperative cortisol secretion function was linked to multiple surgeries and an extended interval between hormone retesting and surgery.ConclusionSurgical intervention effectively ameliorates endocrine disorders in pituitary adenoma patients, thereby mitigating symptoms and enhancing their quality of life. Preoperative management of growth hormone and prolactin levels facilitates an increased remission rate of these hormones post pituitary adenoma surgery. Patients displaying preoperative thyroid hormone secretion dysfunction should be considered for active supplementation therapy. Whenever feasible, complete tumor resection is recommended. For patients undergoing reoperation or multiple surgeries, vigilant postoperative cortisol monitoring and supplementation should be thoughtfully administered.
New insight into the metabolic mechanism of a novel lipid-utilizing and denitrifying bacterium capable of simultaneous removal of nitrogen and grease through transcriptome analysis
Authors: Tong Yaobin , Li Yiyi , Qin Wenpan , Wu Shengchun , Xu Weiping , Jin Peng , Zheng Zhanwang 
Published: October 2023

IntroductionIssues related to fat, oil, and grease from kitchen waste (KFOG) in lipid-containing wastewater are intensifying globally. We reported a novel denitrifying bacterium Pseudomonas CYCN-C with lipid-utilizing activity and high nitrogen-removal efficiency. The aim of the present study was aim to explore the metabolic mechanism of the simultaneous lipid-utilizing and denitrifying bacterium CYCN-C at transcriptome level.MethodsWe comparatively investigated the cell-growth and nitrogen-removal performances of newly reported Pseudomonas glycinae CYCN-C under defined cultivation conditions. Transcriptome analysis was further used to investigate all pathway genes involved in nitrogen metabolism, lipid degradation and utilization, and cell growth at mRNA levels.ResultsCYCN-C could directly use fat, oil, and grease from kitchen waste (KFOG) as carbon source with TN removal efficiency of 73.5%, significantly higher than that (60.9%) with sodium acetate. The change levels of genes under defined KFOG and sodium acetate were analyzed by transcriptome sequencing. Results showed that genes cyo, CsrA, PHAs, and FumC involved in carbon metabolism under KFOG were significantly upregulated by 6.9, 0.7, 26.0, and 19.0-folds, respectively. The genes lipA, lipB, glpD, and glpK of lipid metabolic pathway were upregulated by 0.6, 0.4, 21.5, and 1.3-folds, respectively. KFOG also improved the denitrification efficiency by inducing the expression of the genes nar, nirB, nirD, and norR of denitrification pathways.ConclusionIn summary, this work firstly provides valuable insights into the genes expression of lipid-utilizing and denitrifying bacterium, and provides a new approach for sewage treatment with reuse of KFOG wastes.
The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease
Authors: Sun Yu , Qiao Yanan , Guo Jing , Hou Wenjie , Chen Yaojing , Peng Dantao 
Published: October 2023

IntroductionSubjective cognitive decline (SCD) with a positive amyloid burden has been recognized as the earliest clinical symptom of the preclinical phase of Alzheimers disease (AD), providing invaluable opportunities to improve our understanding of the natural history of AD and determine strategies for early therapeutic interventions.MethodsThe microstructure of white matter in patients showing SCD in the preclinical phase of AD (SCD of pre-AD) was evaluated using diffusion images, and voxel-wise fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities were assessed and compared among participant groups. Significant clusters in the tracts were extracted to determine their associations with alterations in the cognitive domains.ResultsWe found that individuals with SCD of pre-AD may have subclinical episodic memory impairment associated with the global amyloid burden. Meanwhile, we found significantly reduced FA and λ1 in the right cingulum (cingulate and hippocampus) in AD dementia, while significantly increased FA and decreased MD as well as λ23 in the SCD of pre-AD group in comparison with the HC group.DiscussionIn conclusion, increased white matter microstructural integrity in the right cingulum (cingulate and hippocampus) may indicate compensation for short-term episodic memory in individuals with SCD of pre-AD in comparison with individuals with AD and healthy elderly individuals.