bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis
Authors: Aldridge Chad M. , Armstrong Nicole D. , Sunmonu N. Abimbola , Becker Christopher , Palakshappa Deepak , Lindgren Arne G. , Pedersen Annie , Stanne Tara M. , Jern Christina , Maguire Jane , Hsu Fang-Chi , Keene Keith L. , Sale Michele , Irvin Marguerite R. , Worrall Bradford B. 
Published: February 2024

IntroductionStroke is a leading cause of death and disability worldwide. Recurrent strokes are seven times more lethal than initial ones, with 54% leading to long-term disability. Substantial recurrent stroke risk disparities exist among ancestral groups. Notably, Africans face double the risk and higher fatality rates compared to Europeans. Although genetic studies, particularly GWAS, hold promise for uncovering biological insights into recurrent stroke, they remain underexplored. Our study addresses this gap through meta-analyses of recurrent stroke GWAS, considering specific ancestral groups and a combined approach.MethodsWe utilized four independent study cohorts for African, European, and Combined ancestry recurrent stroke GWAS with genotyping, imputation, and strict quality control. We harmonized recurrent stroke phenotype and effect allele estimates across cohorts. The logistic regression GWAS model was adjusted for age, sex, and principal components. We assessed how well genetic risk of stroke informs recurrent stroke risk using Receiver Operating Characteristic (ROC) curve analysis with the GIGASTROKE Consortium's polygenic risk scores (PRS).ResultsHarmonization included 4,420 participants (818 African ancestry and 3,602 European ancestry) with a recurrent stroke rate of 16.8% [median age 66.9 (59.1, 73.6) years; 56.2% male]. We failed to find genome-wide significant variants (p &lt; 5e−8). However, we found 18 distinct suggestive (p &lt; 5e−6) genetic loci with high biological relevance consistent across African and European ancestries, including PPARGC1B, CCDC3, OPRL1, and MYH11 genes. These genes affect vascular stenosis through constriction and dilation. We also observed an association with SDK1 gene, which has been previous linked with hypertension in Nigerian and Japanese populations). ROC analysis showed poor performance of the ischemic stroke PRS in discriminating recurrent stroke status (area under the curve = 0.48).DiscussionOur study revealed genetic associations with recurrent stroke not previously associated with incident ischemic stroke. We found suggestive associations in genes previously linked with hypertension. We also determined that knowing the genetic risk of incident stroke does currently not inform recurrent stroke risk. We urgently need more studies to understand better the overlap or lack thereof between incident and recurrent stroke biology.
The effect of combining green iron nanoparticles and algae on the sustainability of broiler production under heat stress conditions
Authors: Almeldin Yousri A. R. , Eldlebshany Amira E. , Elkhalek Enass Abd , Abdel-Wareth Ahmed A. A. , Lohakare Jayant 
Published: February 2024

BackgroundNatural feed additives in broiler feed contribute to the overall health, productivity, and economic viability of broiler chickens while meeting consumer demands and preferences for natural products. The purpose of this research was to determine the effect of green iron nanoparticles (Nano-Fe) and Halimeda opuntia supplementation in broiler diets on performance, ammonia excretion in excreta, Fe retention in tissues and serum, carcass criteria, and meat quality under hot environmental conditions.MethodsA total of 256 one-day-old male Ross 308 broiler chicks were randomly assigned to one of four feeding treatments for 42 days. Each treatment had eight replications, with eight chicks per replicate. The treatments were Negative control (CON), positive control (POS) supplemented with 1 g/kg Halimeda opuntia as a carrier, POS + 20 mg/kg Nano-Fe (NFH1), POS + 40 mg/kg Nano-Fe (NFH2).ResultsWhen compared to CON and POS, dietary Nano-Fe up to 40 mg/kg enhanced (p &lt; 0.001) growth performance in terms of body weight (BW), body weight gain (BWG), and feed conversion ratio (FCR). Nano-Fe had the highest BWG and the most efficient FCR (linear, p &lt; 0.01, and quadratic, p &lt; 0.01) compared to POS. Without affecting internal organs, the addition of Nano-Fe and POS enhanced dressing and reduced (p &lt; 0.001) abdominal fat compared to control (CON). Notably, the water-holding capacity of breast and leg meat was higher (p &lt; 0.001), and cooking loss was lower in broilers given Nano-Fe and POS diets against CON. In comparison to POS, the ammonia content in excreta dropped linearly as green Nano-Fe levels increased. When compared to CON, increasing levels of Nano-Fe levels boosted Fe content in the breast, leg, liver, and serum. The birds fed on POS showed better performance than the birds fed on CON.ConclusionGreen Nano-Fe up to 40 mg/kg fed to broiler diets using 1 g/kg Halimeda opuntia as a carrier or in single can be utilized as an efficient feed supplement for increasing broiler performance, Fe retentions, carcass characteristics, meat quality, and reducing ammonia excretions, under hot conditions.
Συνουσία in Late Antique Neoplatonic Schools: A Concept between Social History, History of Education and History of Philosophy
Authors: Alviz Fernández Marco , Hernández de la Fuente David 
Published: February 2024

It is well studied that some Pythagorean principles lied at the foundations of the Late Antique Neoplatonic School. The main reason for that conclusion to be drawn is the two biographies of the Samian sage written by the Neoplatonic philosophers Porphyry of Tyre and Iamblichus of Chalcis. Accordingly, the archetypical image of Pythagoras became a major ideal for which every pagan philosopher aimed in Late Antiquity. Henceforth, masters and their disciple circles comprised a micro-society which can reasonably be analyzed as a whole. Suffice it to say that they were small and cohesive charismatic communities whose isolation from the outside world aroused a living harmony from which emerged long-standing emotional bonds. Consequently, the Pythagorically rooted κοινός βίος (Iambl. Vit. Pyth. 6.29: τὸ λεγόμενον κοινοβίους) can easily be ascertained in the biographical literature around the philosophical schools from Plotinus to Damascius (cf. Porph. Vit. Plot. 18.6-14; Procl. In Resp. passim). It is a way of life in common which was also known at the old Athenian Academy (according to Plato’s only explicit reference to Pythagoras (Resp. 600a-b: Πυθαγόρειον τρόπον τοῦ βίου) and has sometimes been defined even as “coenobitic”, in analogy with other contemporary phenomena. But from our point of view, it can be better understood through an analysis of the concept of συνουσία—that is, the meetings of philosophers with their companions (ἑταῖροι) in a specific place which turned into a sort of spiritual household. With this contribution, we aim at focusing on the redefinition of the Neoplatonic συνουσίαι as a legacy of the Platonic notion of συνουσία, stemming from Pythagorean κοινόβιοι. To sum up, we will revise this issue and the state of the art, with the redefinition of Late Antique συνουσία as a terminus technicus in the biographic literature around the Neoplatonic Schools, aiming at opening new paths for the understanding of the Pythagorean–Platonic heritage in Late Antiquity.
Uncovering the Unusual Long Chains of Vegetative Cells within Single Colonies of the Dryland Nitrogen-Fixing Cyanobacterium Nostoc flagelliforme
Authors: Gao Xiang , Liu Chang , Liang Wensheng 
Published: February 2024

Heterocyst-forming cyanobacteria that colonize the drylands contribute to carbon and nitrogen supplies in nutrient-poor soils. As one of the representative cyanobacteria, Nostoc flagelliforme adapts well to the arid environment in the form of filamentous colonies (or filaments). To date, the adaptive changes, either genetic or micromorphological, that occur within single colonies of dryland cyanobacteria remain largely unclear. In this study, unusual long chains or trichomes of vegetative cells (not containing heterocysts) were observed within N. flagelliforme filaments. And the overall heterocyst frequency in the trichomes was counted to be 1.3–2.7%, different from the usually observed 5–10% heterocyst frequency in model Nostoc strains when grown in nitrogen-deprived medium. Thus, these phenomena seem contradictory to our usual recognition of Nostoc strains. Related transcriptional and heterocyst frequency analyses suggested no genetically significant alteration in heterocyst formation and nitrogen fixation in this strain. Also, the amounts of nitrogen sources in the extracellular polysaccharide (EPS) matrix released by N. flagelliforme cells that may cause the low heterocyst frequency were assessed to be equivalent to 0.28–1.10 mM NaNO3. When combining these findings with the habitat characters, it can be envisaged that the released nitrogen sources from cells are confined, accumulated, and re-utilized in the EPS matrix, thereby leading to the formation of reduced heterocyst frequency and long-chained vegetative cells. This study will contribute to our understanding of the distinctive adaptation properties of colonial cyanobacteria in dryland areas.
Falling into the Past: Geodesics in a Time Travel Metric
Authors: MacLaurin Colin , Costa Fabio , Ralph Timothy C. 
Published: February 2024

We investigate timelike and null geodesics within the rotating “time machine” spacetime proposed by Ralph, T.C.; et al. Phys. Rev. D 2020, 102, 124013. This is a rotating analogue of Alcubierre’s warp drive spacetime. We obtain geodesics that begin and end in the surrounding flat space region, yet achieve time travel relative to static observers there. This is a global property, as the geodesics remain locally future-pointing, as well as timelike or null.
Experiencias interculturales en la enseñanza de la Publicidad - aprendizaje colaborativo entre dos universidades de Perú y Colombia
Authors: Neira Daniel Fernando Sabogal , Piscoya Pedro Iván Córdova 
Published: February 2024

Las prácticas y experiencias educativas internacionales y de trabajo colaborativo se fortalecieron en los últimos años debido a condiciones relacionadas con el confinamiento y la pos pandemia. Este artículo reporta estrategias de aprendizaje colaborativo intercultural para la enseñanza de la publicidad mediante una experiencia significativa en dos universidades de Perú y Colombia, que se desarrolla entre 2020 y 2023. Esta experiencia consiste en la asesoría integral en campañas publicitarias a 36 pequeñas y medianas empresas (pymes) de los dos países. La metodología es un estudio de caso mixto, descriptivo, participativo y longitudinal que busca aplicar un modelo pedagógico en el contexto publicitario. Los instrumentos empleados fueron las evaluaciones de los estudiantes a los profesores participantes, los conceptos de los empresarios para valorar la satisfacción de las empresas asesoradas y la sistematización de la experiencia. Los resultados muestran que efectivamente existen factores de interculturalidad, transculturalidad e interculturalidad en las campañas resultantes, que responden a los intereses de los anunciantes colombianos y peruanos, teniendo en consideración el contexto de cada empresa analizada. Las conclusiones muestran que desarrollo del programa colaborativo permitió satisfacer las demandas de las pymes atendidas y contribuyó al aprendizaje intercultural de los estudiantes que formaron parte del programa.
A importância do acolhimento às crianças e adolescentes vítimas de incidentes traumáticos constatados durante o atendimento de ocorrências policiais militares
Authors: Beckert Rodrigo Giovani , Zancan Carolina Pauleto Ferraz 
Published: February 2024

Este artigo suscita a discussão sobre a importância do adequado atendimento das vítimas diretas e indiretas de violência, com idade inferior a 18 anos. Apresenta breve retrospecto histórico sobre a evolução do cuidado e proteção da infância e juventude no mundo, bem como estudos neurocientíficos que buscam comprovar os danos físicos e psicológicos de crianças e adolescentes submetidos a situações traumáticas, por curtos ou longos períodos. Por fim, sob a perspectiva operacional policial, discute ações práticas voltadas ao acolhimento de crianças e de adolescentes impactados ou atingidos pelos desdobramentos decorrentes do atendimento de ocorrências policiais militares de grave repercussão ou complexidade.
De Novo Design of Spiro-Type Hole-Transporting Material: Anisotropic Regulation Toward Efficient and Stable Perovskite Solar Cells
Authors: Wang Xuran , Wang Mingliang , Zhang Zilong , Wei Dong , Cai Shidong , Li Yuheng , Zhang Rui , Zhang Liangliang , Zhang Ruidan , Zhu Chenhui , Huang Xiaozhen , Gao Feng , Gao Peng , Wang Yang , Huang Wei 
Published: February 2024

2,2′,7,7′-Tetrakis(
N
,
N
-di-p-methoxyphenyl)-amine-9,9′-spirobifluorene (Spiro-OMeTAD) represents the state-of-the-art hole-transporting material (HTM) in n-i-p perovskite solar cells (PSCs). However, its susceptibility to stability issues has been a long-standing concern. In this study, we embark on a comprehensive exploration of the untapped potential within the family of spiro-type HTMs using an innovative anisotropic regulation strategy. Diverging from conventional approaches that can only modify spirobifluorene with single functional group, this approach allows us to independently tailor the two orthogonal components of the spiro-skeleton at the molecular level. The newly designed HTM, SF-MPA-MCz, features enhanced thermal stability, precise energy level alignment, superior film morphology, and optimized interfacial properties when compared to Spiro-OMeTAD, which contribute to a remarkable power conversion efficiency (PCE) of 24.53% for PSCs employing SF-MPA-MCz with substantially improved thermal stability and operational stability. Note that the optimal concentration for SF-MPA-MCz solution is only 30 mg/ml, significantly lower than Spiro-OMeTAD (>70 mg/ml), which could remarkably reduce the cost especially for large-area processing in future commercialization. This work presents a promising avenue for the versatile design of multifunctional HTMs, offering a blueprint for achieving efficient and stable PSCs.
Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization
Authors: Yu Chao , Zhao Jing , Cheng Feng , Chen Jiangjie , Chen Jinyang , Xu Haibin , Shi Kesi , Xia Kaishun , Ding Siwen , Wang Kanbin , Wang Ronghao , Chen Yazhou , Li Yi , Li Hao , Chen Qixin , Yu Xiaohua , Shao Fangwei , Liang Chengzhen , Li Fangcai 
Published: February 2024

Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel circATXN1 highly accumulates in aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, and inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous nuclear ribonucleoprotein A2B1-mediated splicing circularization, promotes progerin translocation from the cell nucleus to the cytoplasm and inhibits the expression of insulin-like growth factor 1 receptor (IGF-1R). To demonstrate the therapeutic potential of circATXN1, siRNA targeting the backsplice junction of circATNX1 was screened and delivered by tetrahedral framework nucleic acids (tFNAs) due to their unique compositional and tetrahedral structural features. Our siRNA delivery system demonstrates superior abilities to transfect aging cells, clear intracellular ROS, and enhanced biological safety. Using siRNA–tFNAs to silence circATXN1, aging NPCs exhibit reduced mislocalization of progerin in the cytoplasm and up-regulation of IGF-1R, thereby demonstrating a rejuvenated cellular phenotype and improved mitochondrial function. In vivo, administering an aging cell-adapted siRNA nucleic acid framework delivery system to progerin pathologically expressed premature aging mice (zmpste24
−/−
) can ameliorate the cellular matrix in the nucleus pulposus tissue, effectively delaying IVDD. This study not only identified circATXN1 functioning as a cell senescence promoter in IVDD for the first time, but also successfully demonstrated its therapeutic potential via a tFNA-based siRNA delivery strategy.
Study on the relation between interface trap creation and MOSFET degradation under channel hot carrier stressing at cryogenic temperatures
Authors: Suzuki Tatsuya , Miyaki Yohei , Mitani Yuichiro 
Published: February 2024

Abstract
In general, the degradation mechanism of MOSFETs has been discussed relating to hydrogen. For instance, interface traps are created due to the Si–H bond breakage at the MOS interface by hot (energetic) carriers under electrical stressing (e.g. channel hot carrier (CHC) and F-N stressing). In addition, it is also reported that hydrogen also relates to bulk trap creation. However, these hydrogen-related degradation mechanisms have been discussed based on the results within the conventional measurement temperature region. Recently, the reliabilities of MOSFETs at cryogenic temperatures have attracted much attention assuming that the electron devices are applied to quantum computing and space exploration. However, degradation mechanisms at cryogenic temperatures have yet to be fully clarified. In this paper, the degradations of MOSFETs under a CHC stressing in the temperature range of 77 K ∼ 300 K are investigated. Especially, we focus on the degradation of MOSFETs due to interface trap creation. As a result, MOSFETs degrade more under cryogenic temperature compared to that near RT. This result implies the existence of an additional degradation mechanism at cryogenic temperatures.
CUIDADOS DE ENFERMAGEM NO BANHO DE ASPERSÃO EM INSTITUIÇÃO DE LONGA PERMANÊNCIA: REVISÃO INTEGRATIVA
Authors: De morais Fabiana , Dos Reis Bellaguarda Maria Lígia , Honorio Locks Melissa , Souza Lima Daniella Karine , Chiodelli Nádia , Dutra Tholl Adriana 
Published: February 2024

Objetivo: Identificar os cuidados de enfermagem necessários para o banho de aspersão seguro para idosos no quotidiano de uma instituição de longa permanência. Método: Revisão Integrativa da literatura, recorte entre 2001 e 2022. Os dados dos estudos incluídos resultaram em uma síntese descritiva, fundamentada na Teoria das Necessidades Humanas Básicas. Resultados: Obteve-se 13 estudos sobre cuidados no banho com e sem auxílio, envolvendo o equilíbrio psicobiológico, psicossocial e psicoespiritual, remoção de barreiras ambientais, adaptação domiciliar, maneiras de abordagem, musicoterapia e cuidados com a integridade da pele, oportunizando segurança e qualidade nas ações prestadas. Conclusões: Os cuidados precisam estar integrados às necessidades humanas básicas, respeitando as peculiaridades do processo de envelhecimento e as fragilidades dos idosos mais vulneráveis. A qualificação dos profissionais de enfermagem/cuidadores formais visa a padronização da execução do procedimento e a redução de ocorrência de desvios de procedimento.
SÍNDROME DE CROHN E INTERVENÇÕES CIRÚRGICAS: ENFOQUE INTEGRADO EM ANESTESIA E CIRURGIA GERAL
Authors: Basuino Letícia , Coelho Camilla Bandeira Oliveira , Iaremchuc Katherine , Costa Marco Antônio Penachini da , Nogueira Rafael Pinto , Rocha Marcos Fernando Neiva de Alencar Lustosa , Franco Beatriz Oliveira junqueira , Parazzi Bruna Prado , Souza Vinícius Coelho Pereira de , Brito David Barbosa de , Portugal Fernanda Freire Dantas , Lucena Gabriela de Lima Ferreira , Moraes Vitória Miranda Cardoso de 
Published: February 2024

A Síndrome de Crohn é uma doença inflamatória crônica do trato gastrointestinal, caracterizada por períodos de atividade e remissão, que pode resultar em complicações graves, como estenoses, fístulas e abscessos. Embora o tratamento inicial envolva o uso de medicamentos, uma parcela significativa dos pacientes com Síndrome de Crohn acabam necessitando de intervenções cirúrgicas. Nesse contexto, a abordagem integrada entre anestesia e cirurgia geral desempenha um papel fundamental, garantindo não apenas a eficácia do procedimento cirúrgico, mas também a segurança e o bem-estar do paciente. Objetivo: Discutir as principais considerações envolvidas no manejo anestésico e cirúrgico da Síndrome de Crohn, destacando a importância da abordagem integrada para otimizar os resultados clínicos e a qualidade de vida dos pacientes. Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Medline, com artigos publicados entre os anos 2017 e 2023, disponíveis em inglês ou português. Considerações Finais: Em vista da complexidade da Síndrome de Crohn, uma abordagem integrada entre anestesia e cirurgia geral é essencial para garantir resultados cirúrgicos bem-sucedidos e melhor qualidade de vida para os pacientes. Além disso, a personalização do plano de tratamento, considerando as necessidades individuais de cada paciente, e a educação contínua sobre a doença são cruciais para otimizar os resultados a longo prazo.
Аналіз дендрофлори Дослідної станції тютюнництва ННЦ "ІЗ НААН" України
Authors: Вітенко В. А. , Миколайко В. П. , Подзерей Р. В. , Парахненко В. Г. , Пясецький П. І. , Моргун А. В. 
Published: February 2024

Опрацьовано літературні джерела із аналізу дендрофлори різноманітних науково-дослідних установ нашої країни і за кордоном. Досліджено деревні та кущові рослини, які зростають на території Дослідної станції тютюнництва Національного наукового центру "Інститут землеробства Національної академії аграрних наук України". Проведено аналіз представників дендрофлори даної наукової установи. Встановлено, що до складу деревних рослин Дослідної станції входять представники 20 таксономічних груп із відділів голонасінних (8 таксонів) та покритонасінних (12 таксонів). Співвідношення деревних покритонасінних порід по відношенню до загальної кількості (6824 шт.) насаджень становить 50,5 % (3446 шт.), а голонасінних відповідно 49,5 % (3378 шт.). Проведено розподіл деревних і кущових рослин, які зростають на території Дослідної станції тютюнництва за критеріями посухостійкості, зимостійкості, відношенню до родючості та вологості ґрунту. Впродовж періоду досліджень більшість представників дендрофлори мали високу зимостійкість (рослини перезимували без пошкоджень), а два (Buxus sempervirens L. та Morus alba 'Рendula') достатню. Оцінювання посухостійкості деревних і кущових рослин дало можливість встановити, що 18 таксономічних груп деревних і кущових рослин є посухостійкими, а два види – достатньо посухостійкими. За відношенням до вологості ґрунту деревні та кущові рослин Дослідної станції тютюнництва ННЦ "ІЗ НААН" розподілені на наступні групи: гігрофіти, мезофіти, мезоксерофіт, ксерофіти, а за відношенням до родючості ґрунту дані рослини розподілені в такий спосіб: евтрофи, мезотрони і оліготрофи. Досліджено загальний стан деревних і кущових рослин Дослідної станції тютюнництва, відзначено високий адаптивний потенціал представників дендрофлори до різкої зміни кліматичних умов в останні роки на досліджуваній території і оцінено його як добрий. Надано рекомендації з догляду за деревними та кущовими рослинами та проведено підбір асортименту нових інтродукованих видів та форм деревних і кущових рослин для колекційного поповнення дендрофлори дослідної станції тютюнництва.