bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the role of procalcitonin in COVID-19: a literature review
Authors: Samiullah Syed , Ahmad Amber , Patni Mohamed A. 
Published: January 2024

Procalcitonin (PCT), a key hormone regulating calcium homeostasis, has previously shown the potential to differentiate between bacterial and viral infections. However, when we move further into the field of COVID-19 pandemic, an unprecedented question was raised: Can PCT levels increase without bacterial co-infection in SARS-CoV-2 infection? This review systematically searched PubMed, Scopus, and Google Scholar for articles on procalcitonin (PCT) in the context of COVID-19 published from 2019 to 2023. Inclusion criteria focused on relevant articles, excluding non-English publications. Increasing PCT levels were observed in COVID-19 patients, especially in severe cases, often interpreted as evidence of bacterial co-infection. However, the role of PCT in the immune response to SARS-CoV-2 remains unclear. The proposed mechanisms suggest that SARS-CoV-2 can stimulate the production of PCT even in the absence of bacterial co-infection by modulating the interferon (IFN) pathway and reducing the regulation of monocyte function. Furthermore, PCT has implications in antibiotic management, with guidelines recommended to avoid antibiotics in patients with low serum PCT levels. Increased PCT values show associations with the severity of disease, including increased mortality, which further underlines the need for a detailed understanding of the dynamics of the PCT in COVID-19. This review emphasizes the evolving significance of PCT in COVID-19, with elevated PCT levels emerging as a valuable prognostic indicator, aiding in disease severity assessment and management. However, the intricate dynamics of PCT in COVID-19 demand further investigation, particularly in distinguishing viral infection from bacterial co-infection.
A neurofeedback intervention program to improve teachers’ mental ‎well-‎being
Authors: Passig David , Rubin Osnat , Barry Ilana 
Published: January 2024

Most of the educational interventions proposed so far in the field of mental well-being in education ‎usually address just students. In this study, we focused on teachers as the Covid-19 pandemic reiterated ‎the importance of their mental well-being during demanding times. We investigated whether ‎neurofeedback (NF) training can increase optimism, self-esteem, life satisfaction, and the ability to ‎cope with stressful events, reflecting on the research literature that emphasizes these four factors, ‎which affect the ability to be confident in dealing with uncertainty and distress. ‎
Forty teachers aged 35-55 participated in the study. The test group took part in 12 NF training sessions, ‎and the control group was not treated. Our findings indicate that compared to the control group, ‎measures of optimism, self-esteem, life satisfaction, and coping with stressful events improved ‎significantly in the test group.‎
To the best of our knowledge, this is the first attempt to test a mental welfare intervention program for ‎teachers through NF. This study responded to a call to develop teacher intervention programs using ‎physiological measurement and technological innovations to improve their mental health and allow ‎them to cope better with stressful teaching conditions.
LA RELIGIOSIDAD EN LA SECCIÓN FEMENINA
Authors: SEGORBE HERENCIA Carmen 
Published: January 2024

Tras la Contienda Civil y la victoria de los sublevados contra la II República, el Estado surgido intentaría imponer sus valores tradicionales, sobre todo a las mujeres, contando para ello con los programas de la Sección Femenina (SF), formación que, si bien se integraba en el Estado franquista, no se parecía en absoluto a ninguna otra sección del Movimiento, tanto por su estilo de vida independiente, impensable para el resto del colectivo femenino de la época, como por su forma de entender la religiosidad que, aun siendo tradicional, la manera participativa en la misma fomentaba un incipiente espíritu crítico anticipándose al Concilio Vaticano II , así como a los cambios que más tarde acaecerían, presentando una cierta ``modernidad´´ tampoco nada usual en esta coyuntura
Estudio de caso de Red (2022): Análisis sobre las referencias e influencias asiáticas de la película
Authors: Almoguera Fernández Augusto 
Published: January 2024

La película Red en palabras de su directora Domee Shi, pretende honrar la cultura asiática mediante la combinación de estilos de animación occidentales y orientales con clara inspiración en el anime clásico de los años 90 y principios de los 2000.
Con el objetivo de analizar la representación asiática en la película, se van a analizar las referencias e inspiraciones que convierten a Red en una de las películas con una animación más diferente dentro del estudio. Llegando a la conclusión de que en los últimos años Disney ha decidido apostar por historias protagonizadas por personajes más diversos y visibilizar otro tipo de realidades, siendo la película Red uno de sus ejemplos más claros. Es la primera película de Disney/Pixar escrita, producida y dirigida por mujeres y también la primera cinta de la compañía que se centra en los cambios que experimenta una adolescente, hablando con naturalidad de temas como la menstruación, la pubertad o los padres sobre protectores.
José Chaupis Torres El Califa en su laberinto: esperanza y tragedia del régimen pierolista (1879-1881)
Authors: Saravia Javier 
Published: January 2024

El libro es una compilación de artículos del historiador José Chaupis, sobre uno de los personajes más polémicos de la historia política peruana, Nicolás de Piérola, El Califa. Amado y odiado por la historiografía, es un personaje del que se ha escrito mucho respecto de su personalidad, su labor como funcionario de gobierno, su gestión presidencial y su accionarantes, durante y después de la Guerra del Pacífico. No obstante ello, la valoración de su accionar dentro de la política peruana aún está en ciernes. Un sector informado de la historiografía política nacional lo considera como un protopopulista (Steve Stern) o populista a secas (Jorge Basadre, Jeffrey Klaiber, Alejandro Salinas), por la fuerte presencia de un liderazgocarismático y el gran apoyo popular que tuvo antes de la existencia de los partidos de masas en los primeros años del siglo XX.
Epidemiology of unintentional injuries among 15–24-year-old vocational school youth from Peshawar Pakistan: A cross-sectional survey.
Authors: Masud Sarwat , Hyder Adnan A. , Khan Uzma Rahim , Khan Nadeem Ullah , Raheem Ahmed , Petrucka Pammla 
Published: January 2024

Abstract
Background:
The burden of unintentional injuries among youth (15-24 years) is high. There is paucity of data on unintentional injuries in youth working in Vocational Training Institutes.
Objective: To determine the incidence, characteristics, and risk factors of unintentional injuries among youth.
Methods:
Design: A retrospective cross-sectional survey was conducted among select vocational school youth in Peshawar, Pakistan between February 2022 to October 2022.
Participants: A total of 547 study participants participated in the survey, 356 were males while 191 were females. Data were collected on using the World Health Organization community survey guide for injuries and violence. Multilevel Negative Binomial Regression model was used to report incidence rate ratios of all unitentional injuries.
Results: A total of 503 injuries were reported by the youth, with road traffic injuries being the most common (n=197, 39%), followed by burns (n=89, 18%), falls (n=79, 16%) and poisonings (n=15, 3%), drownings (n=23, 7.1%). Occupational injuries reported during vocational training were (n=95, 18%). Males had a higher incidence rates of RTI 3.24[2.35-5.3], falls 1.30 [0.74-2.27], poisonings 2.14 [0.57-7.58] and drownings 2.46(0.84-7.21), while females had a higher incidence rate of burns 2.19 [1.785-3.46].
Lack of education 4.6 [1.12 -18.91] (p=0.034), smoking 1.25 [1.05 -2.69] (p=0.049), lack of fathers education 4.71 [2.12 -10.49] (p=<0.001), carrying a gun 6.59 [2.54 -17.11] (p=<0.001), crowded families 3.59 [3.11 -5.07] (p=<0.001), lower family income 2.04 [1.04 -4.02](p=0.039*), lack of helmet use 4.54 [2.12 -9.76] (p=<0.001) and lack of seat belt use 1.3 [1.14 -1.69] (p= <0.001) were significant risk factors for unintentional injuries in youth.
Conclusion Added value of the study:
This study is one of the first research studies conducted in vocational school youth in Pakistan. It provides the recent rate of unintentional injuries among the youth of Pakistan. High occupational injuries among vocational school youth were reported which needs further research.
Broadband 3μm MIR emission from Lead-free perovskite fluorine composite glass and CO2 monitoring in H2 applications
Authors: Zhang Yueming , Zhang Xiaosong , Zhang Zhaowei , Li Chao , Chen Minxing , Huang Shuwei , Gong Xiaokai , Xu Jianping , Li Lan 
Published: January 2024

Abstract
The conventional hydrogen production process is accompanied by the production of large amounts of carbon dioxide, which affects the application of hydrogen energy. Therefore, it is necessary to monitor the carbon dioxide content of hydrogen gas. Due to their excellent optical properties, all-inorganic perovskites can be made into photoluminescence sensors for monitoring gas concentrations. However, toxic lead halide perovskites are limited in photoelectric applications due to their instability and other drawbacks. Perovskites have rarely been studied for broadband luminescence in the mid-infrared range. Herein, this work reports on Dy3+/Er3+ co-doped Cs3Bi2-m-nErmDynBr9-ZBLAN (ZrF4-BaF2-LaF3-AlF3-NaF) perovskite fluorine composite glass, which can radiate a broadband mid-infrared luminescence located at 3 µm, covering the characteristic absorption peak of CO2 at 2.7 µm. A CO2 monitoring device is built based on this feature. The use of Bi3+ to replace Pb2+ to form Cs3Bi2Br9 reduces the toxicity of perovskites. The dense and inert nature of the glass is used to isolate the lead-free perovskite Cs3Bi2Br9 from the external environment, thereby improving stability. The addition of Cs3Bi2Br9 not only decreases the phonon density of states in the glass matrix but also changes the local field around the Er and Dy ions. The luminescence of rare earth ions in the mid-infrared is thus enhanced. Cs3Bi2-m-nErmDynBr9-ZBLAN perovskite fluorine composite glass is a promising candidate for future mid-infrared emitting materials due to its non-toxicity and broadband mid-infrared luminescence at 3 µm.
Identification and Validation of Novel Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways
Authors: Wang Yahan , Li Bo-Wen , Xin Chao , Zhang Kai-Xin , Wu Hongyun , Cui Wen-Qiang , Xu Xiang-Qing , Zhang Ji-Wei , Zhi Hong-Wei 
Published: January 2024

Abstract
Background
Alzheimer's disease is a neurodegenerative disease that is difficult to reverse. Akt and Wnt play a role in complex cellular signaling, which is important for studying the onset of AD. This study aimed to screen key genes of the Akt and Wnt pathways as potential biomarkers for the early diagnosis and treatment of AD.
Methods
We searched for differentially expressed genes in the GEO database, constructed candidate gene protein-protein interaction (PPI) networks, and used least absolute shrinkage and selection operator (LASSO) regression analysis and the support vector machine-recursive feature elimination (SVM-RFE) algorithm to screen for key genes. Correlation and functional similarity analyses of key genes, immune infiltration analysis, ceRNA network construction, and drug prediction of key genes were performed. We further validated the expression of key genes in streptozotocin (STZ)-treated AD mice using quantitative reverse transcription (RT-q) PCR.
Results
Bioinformatic analysis identified five key genes in AD, including PRKACA, CDH3, ATP6V0C, DLL1, and CELSR2. Step-down tests, immunohistochemistry, and silver plate staining confirmed the success of STZ-induced AD in mice. PCR showed that the relative expression of DLL1 mNRA in the AD group was higher than that in the control group, whereas the relative expression of ATP6V0C and PRKACA mRNA in the AD group was lower than the control group, which was consistent with the results of the bioinformatic analysis.
Conclusions
This study provides a basis for a more comprehensive understanding of the underlying mechanisms of AD. Furthermore, DLL1, ATP6V0C, and PRKACA may be potential intervention targets for AD.
Best among the key molecular diagnostic markers of bacterial vaginosis
Authors: Deng Tongyang , Song Xiangquan , Liao Qiumei , Zheng Ying , Sun Hong , Zhang Lianzhen , Chen XueJia 
Published: January 2024

Abstract
To assess bacterial vaginosis (BV)-related primary molecular diagnostic markers of Lactobacillus crispatus, Gardnerella vaginalis, Fannyhessea vaginae, bacterial vaginosis-associated bacteria 2 (BVAB-2), Megasphaera-1 and Megasphaera-2 and to discover molecular diagnostic indicators of BV with the most economic value for the efficient diagnosis of BV.All vaginal secretion specimens, including 122 BV-positive cases and 130 BV-negative controls were collected. First, quantitative polymerase chain reaction (PCR) was used to determine the levels of above the six bacteria. Then, the detection rates, sensitivity, specificity, diagnostic threshold, and receiver operating characteristic (ROC) curve were compared.Megasphaera-1 and Megasphaera-2 were detected in the BV-positive group, with a low detection rate of 35.25% and 19.67% respectively. The sensitivity and specificity of the above four bacteria were 95.90%/72.31%, 82.79%/92.48%, 72.13%/95.38%, and 56.56%/94.62% respectively, using the cut-off value for the diagnosis of BV. When combinations of L. crispatus with G. vaginalis, F. vaginae, and BVAB-2 were performed respectively, their sensitivity and specificity were 99.29%/97.79%, 98.86%/98.72%, and 98.22%/98.51% in sequence.It is difficult to diagnose BV using only one species, however, combinations of L. crispatus with G. vaginalis or F. vaginae showed a better diagnostic effect, particularly with the combination of L. crispatus and G. vaginalis.
New 1,3,4-Triaza-3H-indene Derivatives in Theoretical, Experimental and biological Studies
Authors: Ouzidan Younes , Hjouji Mohammed-Yassin , Hafez Baraa , Chraibi Marwa , Ousmane Dounia , Benbrahim Kawtar Fikri , Amanarne Rachida , Abbadi Khalil EL , Latif Mouad , el Hicham , elhenawy Ahmed , Naglah Ahmed , Almehizia Adulrahman A. , Rodi Youssef Kandri 
Published: January 2024

Abstract
6-Bromo-2-phenyl-1,3,4-triazaindan under solid-liquid catalysis-transfer-phase(CTP) environment, pyridine interacts with a number of halogenated derivatives to produce the anticipated regioisomer molecules 2a and 2b. Besides, the reaction of compound (1) with bis(2-chloroethyl) amine results in the corresponding isoxazolidin-2-one derivatives (3a) and (3b) at a satisfactory yield. The synthesized compounds are confirmed by X-ray diffraction, spectral techniques (1H NMR, 13C NMR). Then, 1,3,4-Triaza-3H-indene derivatives were analyzed in silico based on molecular structure by molecular docking analysis to determine which one could be used for in vitro antibacterial activity testing. The compounds with the highest binding efficiency in the docking experiment were chosen to be evaluated against both Gram-positive and Gram-negative bacteria. These compounds showed higher efficacy against Gram-positive bacteria than Gram-negative bacteria, which are much more resistant to them.
Examining lifestyle factors as potential moderators in the link between childhood adversity and comorbid psychological distress and obesity in early adulthood
Authors: Woofenden Tom , Fairchild Graeme , Lancaster Tom 
Published: January 2024

Abstract
Background: Whilst childhood adversities are risk factors for mental, physical, and comorbid health problems in childhood and middle-to-late adulthood, there is less evidence for these associations in early adulthood. It is also unclear if lifestyle factors modify the risk of these health outcomes following childhood adversities. This study aims to examine childhood adversities as risk factors for psychological distress, obesity, and their comorbidity, and further quantify the moderating impact of lifestyle factors. This could provide insight into potential protective influences against the detrimental health consequences of childhood adversities, particularly mental-physical comorbidity.
Methods: Analyses were conducted on data from the 1970 British Cohort Study (n=16,407). The cumulative impact of parent- and self-reported adversities (range 0-33) were consolidated across childhood (0-16 years) and examined as a predictor of psychological distress (Malaise Inventory ≥ 8), obesity (BMI ≥ 30 kg/m2) and their comorbidity in early adulthood (30 years) using multinomial logistic regression. Self-reported lifestyle factors in adolescence (16 years), including physical activity, diet, sleep duration, smoking, and alcohol consumption were assessed as moderators of the association between childhood adversities and the specified outcome categories.
Results: A one-item increase in reported childhood adversities elevated the risk of psychological distress (OR [95% CI]; 1.11 [1.09, 1.13]), obesity (OR [95% CI]; 1.05 [1.03, 1.06]) and mental-physical comorbidity (OR [95% CI]; 1.16 [1.12, 1.20]). Compared to comorbidity, childhood adversity was a weaker risk factor for psychological distress (OR [95% CI]; 0.96 [0.92, 0.99]) or obesity alone (OR [95% CI]; 0.90 [0.87, 0.94]). None of the examined lifestyle factors were significant moderators of the association between childhood adversities and the outcome categories.
Conclusions: Consistent with evidence from middle- to late-adulthood, childhood adversities showed a stronger association with comorbidity in early adulthood than mental or physical health problems alone. There was no evidence that lifestyle factors influenced the association between childhood adversities and comorbidity or individual health problems. Our findings highlight the importance of considering comorbidities when investigating the negative health consequences of childhood adversities, and therefore, the continuing need to identify factors which mitigate the increased risk of comorbidity.
Improving postharvest quality and vase life of cut rose flowers by pre-harvest foliar co-applications of γ-Aminobutyric Acid and calcium chloride through antioxidant contents
Authors: Ehsanimehr Narges , Hosseinifarahi Mehdi , Abdipour Moslem , Eshghi Saeid , Jamali Babak 
Published: January 2024

Abstract
Rose flowers (Rosa hybrida L.) are highly perishable and have a limited postharvest life. This study evaluated the effects of preharvest foliar applications of γ-aminobutyric acid (GABA) and calcium chloride (CaCl2), individually and in combination, on antioxidant responses and vase life of cut Jumilia rose flowers. Treatments included foliar sprays of GABA at 0, 20, 40, and 60 mM and CaCl2 at 0, 0.75%, and 1.5%, applied in a factorial design within a completely randomized setup before harvest. Results showed GABA and CaCl2 interaction (especially, 60 mM GABA and 1.5% CaCl2) significantly increased enzymatic antioxidants including superoxide dismutase, catalase, and peroxidase, as well as non-enzymatic antioxidants such as flavonoids, carotenoids, phenolics, and antioxidant activity in petals compared to control. SOD activity in roses, treated with CaCl2 (1.5%) and GABA (60 mM), peaked at 7.86 units. mg-1 protein min-1, showing a nearly 2.93-fold increase over the control (2.68 units. mg-1 protein min-1). A parallel trend was observed for CAT activity. These treatments also reduced petal malondialdehyde content and polyphenol oxidase activity. Protein content and vase life increased in all treatments. Plants treated with a combination of GABA (20 mM) and CaCl2 (0.75%), GABA (60 mM) and CaCl2 (1.5%), or GABA (40 mM) individually exhibited the longest vase life duration. These findings suggest the preharvest application of GABA and CaCl2 can enhance antioxidant capacity and vase life of cut roses and also delay senescence.
DTMA: Visual Object Inspection and Mechanism for Digital Twin with Robotic Arm
Authors: Venkataraman Hrishikesh , Nidamanuri Jaswanth , Dittakavi Aditya V , Y Raja vara prasad , Trestian Ramona , H Nguyen 
Published: January 2024

Abstract
Over the recent years, the manufacturing sector has been rapidly changing the operational mechanism using advanced technologies such as Artificial Intelli- gence, Computer Vision, etc. The availability of various categories of sensors like IoT, IMU, obstacle detecting sensors, actuators embedded in the system helps to visually monitor the manufacturing process. However, there are many challenges that are yet to be addressed in Cyber-Physical Systems (CPS) and industry
4.0. This includes reliability, precision, adaptability and multi-sensor informa- tion fusion and analysis. Hence, this work proposes an advanced and integrated framework Digital Twin Manipulator Arm (DTMA) that establishes the primary base for industrial level analysis of Digital Twins, including the required concepts of anomaly detection. The main objective of the proposed DTMA framework is three-fold. The first objective is to design a digital twin of robotic arm. The second is to design the visual inspection module for object inspection in man- ufacturing process. The third objective is to integrate both the modules with automated correction using robotic arm in to the entire process. The applica- tion of DTMA framework is gauged from two different use-cases discussing the heuristic based block level functioning of the proposed framework. The proposed framework will enable the development of mechanisms for key advantages such as predictive maintenance, reduced operation cost, visual inspection with higher processing rates and improved productivity.
Clinical and microbiological characteristics of persistent Staphylococcus aureus bacteremia and risk factors for mortality: CD4 + T cells play an important role
Authors: Yang Eunmi , Cho Yeong Geon , Kim Eunsil , Chang Euijin , Bae Seongman , Jung Jiwon , Kim Min Jae , Chong Yong Pil , Kim Sung-Han , Choi Sang-Ho , Lee Sang-Oh , Chung Yun Shin , Kim Yang Soo 
Published: January 2024

Abstract
Objectives
This study evaluated the risk factors for mortality and the T cell immune response in patients with persistent Staphylococcus aureus bacteremia (SAB).
Methods
We studied a prospective cohort of adults with SAB at a tertiary-care hospital in South Korea from 2008 to 2020. We compared the clinical and microbiological characteristics of patients with persistent bacteremia (PB). The concentrations of cytokines and the proportions of IFN-γ secreting CD4+ T cells were measured serially during the bacteremia period.
Results
Of the 1,760 patients, 242 had PB, and 49 PB patients died within 30 days. In the multivariate analysis, the APACHE II score, liver cirrhosis, and female sex were independently associated with 30-day mortality. The level of IL-10 was significantly increased in the plasma of patients with a high Pitt bacteremia score and those who died within 12 weeks from the index day. The proportion of IFN-γ-secreting CD4+ T cells were the highest just before the positive-to-negative conversion of blood cultures in patients with a low Pitt bacteremia score and those who survived for 12 weeks.
Conclusions
The level of IL-10 is correlated with clinical outcomes in PB patients. IFN-γ secreting CD4+ T cells might play a pivotal role in SAB PB.