bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We Came Together and We Fought”
Authors: Ramey Jessie B. , Evans Catherine A. 
Published: January 2024

Abstract
For over sixty years Kipp Dawson has built coalitions on the front lines of the civil rights movement, Vietnam antiwar movement, women’s movement, gay liberation movement, labor movement, and education justice movement, confronting state-sponsored violence and challenging systems of active harm and death. Her astonishing career—and marginalized identities as a lesbian, Jewish, working-class woman from a multiracial family—demonstrates the radical power of ordinary people engaged in collective, transformative action. In this visual essay, the authors share material from two new archival collections spanning the remarkable breadth and depth of Dawson’s intersectional feminist activism. They suggest rethinking movement leadership as women’s radical collaboration and demonstrate its role in organizing both resistance to state violence and alternative visions for the nation.
The “Knocking Heart”
Authors: Moon Sarah 
Published: January 2024

AbstractThis article argues that the oral performance of personal monologues in first-year composition courses allows students to identify meaningfully with one another across difference at a time when the American political climate too often forecloses such opportunities. The author considers the opportunity personal monologue provides for parrhesia that recontextualizes the space in which deliberative discourse occurs. Drawing on a case study of the author's food-based composition course, this article provides supporting evidence for the power of performed personal monologue to encourage mutual identification among students that creates a new foundation for subsequent discourse.
Object Encounters
Authors: Kao Vivian 
Published: January 2024

AbstractDrawing on object-oriented approaches to rhetoric and the scholarship of museum education, the author describes her development of a first-year composition experience that puts observation at the center of first-year writing—observation of an art object and its context of display, as well as self-observation of a writer interacting with that object. The experience uses these object-oriented encounters to broaden students’ understanding of the role that close observation plays in effective writing while acting as a case study for how first-year composition instructors can draw on object and museum theories to design experiences and assignments conducted outside of traditional classroom spaces.
The Cl− transporter ClC-7 is essential for phagocytic clearance by microglia
Authors: Iyer Harini , Talbot William S. 
Published: January 2024

ABSTRACT
Microglia, professional phagocytic cells of the brain, rely upon the appropriate activation of lysosomes to execute their immune and clearance functions. Lysosomal activity is, in turn, modulated by a complex network of over 200 membrane and accessory proteins that relay extracellular cues to these key degradation centers. The ClC-7 chloride (Cl−)-proton (H+) antiporter (also known as CLCN7) is localized to the endolysosomal compartments and mutations in CLCN7 lead to osteopetrosis and neurodegeneration. Although the functions of ClC-7 have been extensively investigated in osteoclasts and neurons, its role in microglia in vivo remains largely unexamined. Here, we show that microglia and embryonic macrophages in zebrafish clcn7 mutants cannot effectively process extracellular debris in the form of apoptotic cells and β-amyloid. Despite these functional defects, microglia develop normally in clcn7 mutants and display normal expression of endosomal and lysosomal markers. We also find that mutants for ostm1, which encodes the β-subunit of ClC-7, have a phenotype that is strikingly similar to that of clcn7 mutants. Together, our observations uncover a previously unappreciated role of ClC-7 in microglia and contribute to the understanding of the neurodegenerative phenotypes that accompany mutations in this channel.
Ankylosing spondylitis coexisting with Clonorchis sinensis infection: A case report
Authors: Yi Tian-Xin , Liu Wei , Leng Wen-Fei , Wang Xiao-Chuan , Luo Liang 
Published: January 2024

BACKGROUND
Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease. The prevailing theory links AS onset to infections in susceptible individuals. Furthermore, infections may impair the immune responses. Numerous studies have investigated links between AS and various infections-bacterial, viral, fungal, and other microorganism infections. However, limited attention has been given to the association between AS and Clonorchis sinensis (C. sinensis ) infection.
CASE SUMMARY
A 27-year-old male with a 10-yr history of AS presented to our hospital with inflammatory lower back pain as the primary manifestation. Ten years ago, the patient had achieved a stable condition after treatment with biological agents. However, he experienced a recurrence of lumbosacral pain with an unexplained cause 10 d before hospital admission. A lumbosacral magnetic resonance imaging (MRI) scan revealed bone marrow edema in the left sacroiliac joint, and laboratory indicators were elevated. Moreover, the presence of C. sinensis eggs was detected in the stool. The patient was prescribed praziquantel, resulting in the disappearance of C. sinensis eggs in subsequent routine stool tests and relief from lumbosacral pain. A follow-up MRI scan performed after 4 months revealed a reduction in bone marrow edema around the left sacroiliac joint.
CONCLUSION
C. sinensis infections could potentially trigger the exacerbation of AS. Clinicians should pay attention to investigating the presence of infections.
A six years trend analysis of systemic antibiotic consumption in Northwest Ethiopia
Authors: Abejew Asrat Agalu , Wubetu Gizachew Yismaw , Fenta Teferi Gedif 
Published: January 2024

Background
Consumption of antibiotics, a major global threat to public health, is perhaps the key driver of antibiotic resistance. Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. This study assessed antibiotic consumption trends during the last six years in the Bahir Dar branch of the Ethiopian pharmaceutical supply agency (EPSA), Northwest Ethiopia, in 2022.

Methods
Retrospective data were collected in August 2022 based on antibiotic distribution data from the Bahir Dar Brach of EPSA from July 2016 to June 2022. Data were analyzed according to the Anatomic Therapeutic Classification (ATC) developed by the World Health Organization (WHO). We measured antibiotic consumption using a defined daily dose per 1000 inhabitants per day (DIDs) based on the Agency’s catchment population. Descriptive statistics and trend analyses were conducted.

Results
About 30.34 DIDs of antibiotics were consumed during the six years. The consumption of antibiotics decreased by 87.4%, from 6.9 DIDs in 2016/17 to 0.9 DIDs in 2021/22. Based on the WHO AWaRe classification, 23.39 DIDs (77.1%) of the consumed antibiotics were from the Access category. Consumption of Access category antibiotics was decreased by 72.7% (from 5 to 0.5 DIDs) but Watch antibiotics decreased by 54.3% (from 1.8 to 0.4 DIDs). Oral antibiotics accounted for 29.19 DIDs (96.2%) of all consumed systemic antibiotics. The average cost expenditure per DDD for all antibiotics was 54.1 birr/DDD (0.4–482.3 birr/DDD). Only seven antibiotics accounted for DU90% and the cost expenditure per DDD for the DU90% antibiotics ranged from 0.4/DDD for Doxycycline to 232.8 birr/DDD for Piperacillin/tazobactam. Overall, during the last six years, the most commonly used antibiotic was Amoxicillin (10.1 DIDs), followed by Doxycycline (5.3 DIDs) and Ciprofloxacin (3.4 DIDs).

Conclusion
In this study, we found that antibiotic usage was low and continuously declining over time. Minimizing unnecessary antibiotic usage is one possible approach to reduced AMR. However, a shortage of access to important medicines can compromise the quality of treatment and patient outcomes. A prospective study is needed to evaluate the balance of patient outcomes and reduce AMR by optimizing the community consumption of systemic antibiotics.
Impact of COVID-19 pandemic in the Brazilian maternal mortality ratio: A comparative analysis of Neural Networks Autoregression, Holt-Winters exponential smoothing, and Autoregressive Integrated Moving Average models
Authors: Cañedo Mayara Carolina , Lopes Thiago Inácio Barros , Rossato Luana , Nunes Isadora Batista , Faccin Izadora Dillis , Salomé Túlio Máximo , Simionatto Simone 
Published: January 2024

Background and objectives
The acute respiratory infection caused by severe acute respiratory syndrome coronavirus disease (COVID-19) has resulted in increased mortality among pregnant, puerperal, and neonates. Brazil has the highest number of maternal deaths and a distressing fatality rate of 7.2%, more than double the country’s current mortality rate of 2.8%. This study investigates the impact of the COVID-19 pandemic on the Brazilian Maternal Mortality Ratio (BMMR) and forecasts the BMMR up to 2025.

Methods
To assess the impact of the COVID-19 pandemic on the BMMR, we employed Holt-Winters, Autoregressive Integrated Moving Average (ARIMA), and Neural Networks Autoregression (NNA). We utilized a retrospective time series spanning twenty-five years (1996–2021) to forecast the BMMR under both a COVID-19 pandemic scenario and a controlled COVID-19 scenario.

Results
Brazil consistently exhibited high maternal mortality values (mean BMMR [1996–2019] = 57.99 ±6.34/100,000 live births) according to World Health Organization criteria. The country experienced its highest mortality peak in the historical BMMR series in the second quarter of 2021 (197.75/100,000 live births), representing a more than 200% increase compared to the previous period. Holt-Winter and ARIMA models demonstrated better agreement with prediction results beyond the sample data, although NNA provided a better fit to previous data.

Conclusions
Our study revealed an increase in BMMR and its temporal correlation with COVID-19 incidence. Additionally, it showed that Holt-Winter and ARIMA models can be employed for BMMR forecasting with lower errors. This information can assist governments and public health agencies in making timely and informed decisions.
Maternal and perinatal outcomes of hypertensive disorders in pregnancy: Insights from the National Hospital of Obstetrics and Gynecology in Vietnam
Authors: Thi Huyen Anh Nguyen , Manh Thang Nguyen , Thanh Huong Truong 
Published: January 2024

Introduction
Hypertension is the common disorder encountered during pregnancy, complicating 5% to 10% of all pregnancies. Hypertensive disorders in pregnancy (HDP) are also a leading cause of maternal and perinatal morbidity and mortality. The majority of feto-maternal complications due to HPD have occurred in the low- and middle-income countries. However, few studies have been done to assess the feto-maternal outcomes and the predictors of adverse perinatal outcome among women with HDP in these countries.

Methods
A prospective cohort study was conducted on women with HDP who were delivered at National Hospital of Obstetrics and Gynecology, Vietnam from March 2023 to July 2023. Socio-demographic and obstetrics characteristics, and feto-maternal outcomes were obtained by trained study staff from interviews and medical records. Statistical analysis was performed using SPSS version 26.0. Bivariate and multiple logistic regressions were done to determine factors associated with adverse perinatal outcome. A 95% confidence interval not including 1 was considered statically significant.

Results
A total of 255 women with HDP were enrolled. Regarding adverse maternal outcomes, HELLP syndrome (3.9%), placental abruption (1.6%), and eclampsia (1.2%) were three most common complications. There was no maternal death associated with HDP. The most common perinatal complication was preterm delivery developed in 160 (62.7%) of neonates. Eight stillbirths (3.1%) were recorded whereas the perinatal mortality was 6.3%. On bivariate logistic regression, variables such as residence, type of HDP, highest systolic BP, highest diastolic BP, platelet count, severity symptoms, and birth weight were found to be associated with adverse perinatal outcome. On multiple logistic regression, highest diastolic BP, severity symptoms, and birth weight were found to be independent predictors of adverse perinatal outcome.

Conclusion
Our study showed lower prevalence of stillbirth, perinatal mortality, and maternal complication compared to some previous studies. Regular antenatal care and early detection of abnormal signs during pregnancy help to devise an appropriate monitoring and treatment strategies for each women with HDP.
Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis
Authors: Lembo Anthony J. , Chey William D. , Harris Lucinda A. , Frazier Rosita , Brenner Darren M. , Chang Lin , Lacy Brian E. , Edelstein Susan , Yang Yang , Zhao Suling , Rosenbaum David P. 
Published: January 2024

INTRODUCTION:
This post hoc analysis evaluated the efficacy of tenapanor on abdominal symptoms in patients with irritable bowel syndrome with constipation. Abdominal symptoms assessed included pain, discomfort, bloating, cramping, and fullness.

METHODS:
The abdominal symptom data were pooled from 3 randomized controlled trials (NCT01923428, T3MPO-1 [NCT02621892], and T3MPO-2 [NCT02686138]). Weekly scores were calculated for each abdominal symptom, and the Abdominal Score (AS) was derived as the average of weekly scores for abdominal pain, discomfort, and bloating. The overall change from baseline during the 12 weeks was assessed for each symptom weekly score and the AS. The AS 6/12-week and 9/12-week response rates (AS improvement of ≥2 points for ≥6/12- or ≥9/12-week) were also evaluated. The association of weekly AS response status (reduction of ≥30%) with weekly complete spontaneous bowel movement (CSBM) status (=0 and >0) was assessed.

RESULTS:
Among 1,372 patients (684 tenapanor [50 mg twice a day] and 688 placebo), the least squares mean change from baseline in AS was −2.66 for tenapanor vs −2.09 for placebo (P < 0.0001). The 6/12-week AS response rate was 44.4% for tenapanor vs 32.4% for placebo (P < 0.0001), and for 9/12-week AS, 30.6% for tenapanor vs 20.5% for placebo (P < 0.0001). A significant association between weekly CSBM status and weekly AS response status was observed each week (P < 0.0001), with a greater proportion achieving an AS reduction in patients with >0 CSBMs in a week.

DISCUSSION:
Tenapanor significantly reduced abdominal symptoms in patients with irritable bowel syndrome with constipation, particularly pain, discomfort, and bloating measured by AS, compared with placebo.
Surgical Outcome of Postinfarction Left Ventricular Free Wall Rupture
Authors: Na Chan-young 
Published: January 2024

Abstract

Background:
Left ventricular free wall rupture (LVFWR) is a rare and fatal complication after acute myocardial infarction. Early recognition and aggressive treatment are recommended.

Methods:
Between August 1999 and February 2023, 11 patients aged between 64 and 79 years developed LVFWR after acute myocardial infarction (mean interval, 3.5 days). Three patients had active bleeding (blowout-type LVFWR), and the other 8 patients experienced the oozing or sealed state. Eight patients were treated using a sutureless technique with Teflon felt and glue, 2 patients were treated using the primary suture closure technique, and 1 was treated using both the primary suture and the sutureless technique with Teflon felt and glue.

Results:
One patient died in the operating room as a result of bleeding. Cardiovascular stability and hemostasis were achieved in the other 10 patients. There were 3 early deaths (all 3 cases as a result of area bleeding; 1 was treated with primary suture, 2 with sutureless glue). Three patients received percutaneous coronary intervention before discharge. All 8 remaining patients survived and were discharged. Three patients were lost to follow-up. The follow-up period ranged from 2 to 97 months, with 4 patients exhibiting New York Heart Association class I symptoms and 1 exhibiting New York Heart Association class II symptoms.

Conclusion:
Optimal surgical treatment for postinfarction LVFWR remains controversial. The sutureless technique may be a promising strategy for treating postinfarction LVFWR.
The times of COVID-19 and beyond: how laboratory teaching evolved through the Pandemic
Authors: Logothetis Thomas A. 
Published: January 2024

Abstract
Pre–during–post lockdown waves, or how COVID-19 catalysed a change in practical chemistry instruction. This time-lined slogan reflects the University of Southampton’s response to recent imperatives in chemistry education. During the pandemic students had limited access to laboratory training. However, laboratory time has always been precious, and educators constantly have to rethink their approach to lab classes; how to best assess practical learning goals and focus students’ attention on the practical aspects during timetabled – and therefore time-limited – lab classes. The pre–during–post pandemic phases also govern the teaching split of our typical laboratory instruction, and the development during the three phases will be discussed. This article describes the evolution of the University of Southampton’s laboratory training, how resources changed, how in-laboratory student participation improved, how the pandemic influenced the scheduling of teaching activities and informed a development of our assessment strategy. It considers where the rethinking process has led to so far while acknowledging that the current laboratory course is not the end of the process but an interim position, subject to future improvements.
Better safe than sorry: dual targeting antibodies for cancer immunotherapy
Authors: Schoenfeld Katrin , Harwardt Julia , Kolmar Harald 
Published: January 2024

Abstract
Antibody-based therapies are revolutionizing cancer treatment and experience a steady increase from preclinical and clinical pipelines to market share. While the clinical success of monoclonal antibodies is frequently limited by low response rates, treatment resistance and various other factors, multispecific antibodies open up new prospects by addressing tumor complexity as well as immune response actuation potently improving safety and efficacy. Novel antibody approaches involve simultaneous binding of two antigens on one cell implying increased specificity and reduced tumor escape for dual tumor-associated antigen targeting and enhanced and durable cytotoxic effects for dual immune cell-related antigen targeting. This article reviews antibody and cell-based therapeutics for oncology with intrinsic dual targeting of either tumor cells or immune cells. As revealed in various preclinical studies and clinical trials, dual targeting molecules are promising candidates constituting the next generation of antibody drugs for fighting cancer.
Heat transfer characteristics of cobalt ferrite nanoparticles scattered in sodium alginate-based non-Newtonian nanofluid over a stretching/shrinking horizontal plane surface
Authors: Elattar Samia , Khan Umair , Zaib Aurang , Ishak Anuar , Alwadai Norah , Abed Ahmed M. 
Published: January 2024

Abstract
Magnetite and cobalt ferrite (CoFe2O4) nanoparticles are frequently utilized in several applications, including magnetic drug delivery, hyperthermia, magnetic resonance imaging, etc. In the current investigation, the magnetohydrodynamic three-dimensional heat transfer (HT) flow induced by a non-Newtonian Eyring–Powell fluid is incorporated by a carrier sodium alginate (NAC6H7O6)-based CoFe2O4 nanoparticles over a deformable (stretching/shrinking) horizontal plane surface with orthogonal shear stress and power-law velocity. The HT analysis along with the substantial effect of irregular heat source/sink as well as entropy generation is also performed. The similarity variables altered the posited leading equations into ordinary differential (similarity) equations. The function bvp4c in Matlab is then used to solve these equations numerically for various parameter values. Results indicate that, in general, there are two alternative solutions for the phenomenon of suction and deformable parameters. In addition, the essential thermal evaluation is enhanced owing to the significance of CoFe2O4 nanoparticles, magnetic parameter, and irregular heat source/sink.
Synthesis of a benzothiazole-based structure as a selective colorimetric-fluorogenic cyanate chemosensor
Authors: Kayhan Emine , Bozkurt Selahattin , Kayhan Mehmet 
Published: January 2024

Abstract
In this study, a new heterocyclic compound incorporating a benzothiazole moiety was specifically designed for the detection of cyanate anions, employing a hydrogen bonding mechanism. Through strategic integration of triazine and phenylenediamine cyclic groups into the compound’s structure, intramolecular hydrogen bonding interactions between the donor and acceptor sites were enhanced, leading to exceptional sensitivity towards cyanate anions. Utilizing the amino-type excited-state intramolecular proton transfer phenomenon, this new compound exhibited dual signals and achieved a significant Stokes’ shift via proton transfer, coupled with aggregation-induced emission properties. This unique combination resulted in visible color changes and an impressive fluorescence response, offering a promising solution for the sensitive detection of cyanate ions in critical environmental matrices. Cyanate detection at low concentrations by this as-synthesized compound (L1), accompanied by a distinct color change and a gradual fluorescence increase upon incremental cyanate addition demonstrated L1’s selectivity, as confirmed in the presence of various competing anions F−, Cl−, Br−, I−,

ClO

3

−

{\text{ClO}}_{3}^{-}

,

ClO

4

−

{\text{ClO}}_{4}^{-}

,

NO

3

−

{\text{NO}}_{3}^{-}

,

BrO

3

−

{\text{BrO}}_{3}^{-}

, CN− and CNO−. Spectrofluorometric investigations demonstrated that L1 shows significant potential as a selective cyanate anion detection candidate.
Gas dynamic analysis of the modern single shaft gas turbine engine flow path
Authors: Morhun Serhii , Vilkul Sergii 
Published: January 2024

Abstract
The paper outlines a finite volumes refined mathematical model of the working gas flow in the flow path of the three stage modern single shaft gas turbine engine that can be used in floating power plants. Such mathematical model based on the finite volumes of hexagonal-type was constructed using the three-dimensional Navier–Stokes equations for the case of viscous working fluid flow. For the problem solution such boundary conditions as “inlet’, “outlet” and “wall” have been used. The calculation is carried out in a non-stationary setting with a time step of 1.5974 × 10−6 s, which corresponds to the angle of rotation of the rotor, relative to the stator, of 0.09°. The total number of time iterations is 350. Also, it was shown that the variation field of pressure on the blades feather surfaces and the gas flow velocity due to rotation are the critical factors, causing the blades vibration. The result was confirmed with the experiment. The obtained results would be used as a base for further investigations of gas flow pressure field on the blades surface, because the gas flow pressure are key factors, causing the rotor forced vibration, and as initial data for their fatigue strength and crack study.