bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Forming of Nitric Oxide and Electric Stimulus for Nerve Therapy by Wireless Chargeable Gold Yarn‐Dynamos
Authors: Chiang Min‐Ren , Lin Ya‐Hui , Zhao Wei‐Jie , Liu Hsiu‐Ching , Hsu Ru‐Siou , Chou Tsu‐Chin , Lu Tsai‐Te , Lee I‐Chi , Liao Lun‐De , Chiou Shih‐Hwa , Chu Li‐An , Hu Shang‐Hsiu 
Published: October 2023

AbstractEndogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half‐life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on‐demand high‐frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S‐nitrosoglutathione), pGSNO)‐conjugated on a gold yarn‐dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo.
Biomimetic Intrafibrillar Mineralization of Native Tendon for Soft–Hard Interface Integration by Infiltration of Amorphous Calcium Phosphate Precursors
Authors: Chen Yangwu , Zhang Yuxiang , Chen Xiaoyi , Huang Jiayun , Zhou Bo , Zhang Tao , Yin Wei , Fang Cailian , Yin Zi , Pan Haihua , Li Xiongfeng , Shen Weiliang , Chen Xiao 
Published: October 2023

AbstractSoft and hard tissues possess distinct biological properties. Integrating the soft‐hard interface is difficult due to the inherent non‐osteogenesis of soft tissue, especially of anterior cruciate ligament and rotator cuff reconstruction. This property makes it difficult for tendons to be mineralized and integrated with bone in vivo. To overcome this challenge, a biomimetic mineralization strategy is employed to engineer mineralized tendons. The strategy involved infiltrating amorphous calcium phosphate precursors into collagen fibrils, resulting in hydroxyapatite deposition along the c‐axis. The mineralized tendon presented characteristics similar to bone tissue and induced osteogenic differentiation of mesenchymal stem cells. Additionally, the interface between the newly formed bone and tendon is serrated, suggesting a superb integration between the two tissues. This strategy allows for biomineralization of tendon collagen and replicating the hallmarks of the bone matrix and extracellular niche, including nanostructure and inherent osteoinductive properties, ultimately facilitating the integration of soft and hard tissues.
Nano‐Plumber Reshapes Glymphatic‐Lymphatic System to Sustain Microenvironment Homeostasis and Improve Long‐Term Prognosis after Traumatic Brain Injury
Authors: Tong Shiqiang , Xie Laozhi , Xie Xiaoying , Xu Jianpei , You Yang , Sun Yinzhe , Zhou Songlei , Ma Chuchu , Jiang Gan , Ma Fenfen , Wang Zhihua , Gao Xiaoling , Chen Jun 
Published: October 2023

AbstractTraumatic brain injury (TBI) is a leading cause of death and disability worldwide. Long‐term changes in the microenvironment of the brain contribute to the degeneration of neurological function following TBI. However, current research focuses primarily on short‐term modulation during the early phases of TBI, not on the critical significance of long‐term homeostasis in the brain microenvironment. Notably, dysfunction of the glymphatic‐lymphatic system results in the accumulation of danger/damage‐associated molecular patterns (DAMPs) in the brain, which is regarded as the leading cause of long‐term microenvironmental disturbances following TBI. Here, a nanostructure, Nano‐plumber, that co‐encapsulates the microenvironment regulator pro‐DHA and the lymphatic‐specific growth factor VEGF‐C is developed, allowing for a sustainable and orderly regulation of the microenvironment to promote long‐term neurological recovery. Nano‐plumber reverses the injury microenvironment by suppressing microglia and astrocytes activation and maintaining reduced activation via enhanced glymphatic‐lymphatic drainage, and significantly improves the neurological function of rodents with TBI. This study demonstrates that glymphatic‐lymphatic system reconstruction is essential for enhancing long‐term prognosis following TBI, and that the Nano‐plumber developed here may serve as a clinically translatable treatment option for TBI.
Passive Internet of Events Enabled by Broadly Compatible Self‐Powered Visualized Platform Toward Real‐Time Surveillance
Authors: Chen Chaojie , Zhang Haoran , Xu Guoqiang , Hou Tingting , Fu Jingjing , Wang Haoyu , Xia Xin , Yang Cheng , Zi Yunlong 
Published: October 2023

AbstractSurveillance is an intricate challenge worldwide especially in those complicated environments such as nuclear plants, banks, crowded areas, barns, etc. Deploying self‐powered wireless sensor nodes can increase the system's event detection capabilities by collecting environmental changes, while the incompatibility among components (energy harvesters, sensors, and wireless modules) limits their application. Here, a broadly compatible self‐powered visualized platform (SPVP) is reported to construct a passive internet of events (IoE) network for surveillance systems. By encoding electric signals into reference and working LEDs, SPVP can visualize resistance change generated by commercial resistive sensors with a broad working range (<107 Ω) and the transmission distance is up to 30 meters. Visible light signals are captured by surveillance cameras and processed by the cloud to achieve real‐time event monitoring and identification, which forms the passive IoE network. It is demonstrated that the passive‐IoE‐based surveillance system can detect intrusion, theft, fire alarm, and distress signals quickly (30 ms) for 106cycles. Moreover, the confidential information can be encrypted by SPVPs and accessed through a phone application. This universal scheme may have huge potential for the construction of safe and smart cities.
Ferrocene Derivatives for Improving the Efficiency and Stability of MA‐Free Perovskite Solar Cells from the Perspective of Inhibiting Ion Migration and Releasing Film Stress
Authors: Bi Huan , Liu Jiaqi , Zhang Zheng , Wang Liang , Kapil Gaurav , Wei Yuyao , Kumar Baranwal Ajay , Razey Sahamir Shahrir , Sanehira Yoshitaka , Wang Dandan , Yang Yongge , Kitamura Takeshi , Beresneviciute Raminta , Grigalevicius Saulius , Shen Qing , Hayase Shuzi 
Published: October 2023

AbstractFurther improvement of the performance and stability of inverted perovskite solar cells (PSCs) is necessary for commercialization. Here, ferrocene derivative dibenzoylferrocene (DBzFe) is used as an additive to enhance the performance and stability of MA‐ and Br‐ free PSCs. The results show that the introduction of DBzFe not only passivates the defects in the film but also inhibits the ion migration in the film. The final device achieves a power conversion efficiency (PCE) of 23.53%, which is one of the highest efficiencies currently based on self‐assembled monolayers (SAMs). Moreover, it maintains more than 96.4% of the original efficiency when running continuously for 400 h at the maximum power point.
Ultra‐Fast Recyclable and Value‐Added Desulfation Method for Spent Lead Paste via Dual Intensification Processes
Authors: Chai Lulu , Li Zhiyu , Wang Keyu , Liu Xiaowei , Dai Shaozhen , Liu Xiaoguang , Sun Yanzhi , Pan Junqing 
Published: October 2023

AbstractThe new low‐cost clean pre‐desulfation technology is very important in pyrometallurgy and hydrometallurgy. However, traditional reactors have low space‐time yield and desulfation rate, resulting in high energy consumption and SO2 emissions in the industrial desulfation processes. Herein, dual rotating liquid film reactors (RLFRs) and lime are proposed to construct a recyclable, ultra‐fast, and value‐added desulfation method. Parameter optimization and kinetic calculations prove that the above reactions are controlled by internal diffusion, revealing that RLFR promotes the mass transfer and reaction rate. The new process greatly shortens the desulfation time of lead paste from 40 min to 10 s with a high desulfation rate of 99.7%, and the sulfation time of lime from 30 min to 30 s with a sulfation rate of 98.6% with a net profit of 55.99 ¥/ton by cost accounting. Moreover, ten batches of continuous scale‐up experiments demonstrate the stability of processes, the desulfation and sulfation rates are kept at 99.7% and 98.2%, which greatly reduces the emissions of waste desulfate liquor. This work provides a new universal strategy for a sustainable, low‐cost, and clean desulfation method of waste resources to achieve technical and economic feasibility.
Diversity‐Oriented Catalytic Asymmetric Dearomatization of Indoles with o‐Quinone Diimides
Authors: Gao Hao‐Jie , Miao Yu‐Hang , Sun Wen‐Na , Zhao Rui , Xiao Xiao , Hua Yuan‐Zhao , Jia Shi‐Kun , Wang Min‐Can , Mei Guang‐Jian 
Published: October 2023

AbstractHerein, the first diversity‐oriented catalytic asymmetric dearomatization of indoles with o‐quinone diimides (o‐QDIs) is reported. The catalytic asymmetric dearomatization (CADA) of indoles is one of the research focuses in terms of the structural and biological importance of dearomatized indole derivatives. Although great achievements have been made in target‐oriented CADA reactions, diversity‐oriented CADA reactions are regarded as more challenging and remain elusive due to the lack of synthons featuring multiple reaction sites and the difficulty in precise control of chemo‐, regio‐, and enantio‐selectivity. In this work, o‐QDIs are employed as a versatile building block, enabling the chemo‐divergent dearomative arylation and [4 + 2] cycloaddition reactions of indoles. Under the catalysis of chiral phosphoric acid and mild conditions, various indolenines, furoindolines/pyrroloindolines, and six‐membered‐ring fused indolines are collectively prepared in good yields with excellent enantioselectivities. This diversity‐oriented synthesis protocol enriches the o‐quinone chemistry and offers new opportunities for CADA reactions.
Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4
Authors: Lee Woo Ho , Hong Kyung Jin , Li Hua‐Bing , Lee Gap Ryol 
Published: October 2023

AbstractT helper type 9 (Th9) cells play important roles in immune responses by producing interleukin‐9 (IL‐9). Several transcription factors are responsible for Th9 cell differentiation; however, transcriptional regulation of Th9 cells is not fully understood. Here, it is shown that Id1 is an essential transcriptional regulator of Th9 cell differentiation. Id1 is induced by IL‐4 and TGF‐β. Id1‐deficient naïve CD4 T cells fail to differentiate into Th9 cells, and overexpression of Id1 induce expression of IL‐9. Mass spectrometry analysis reveals that Id1 interacts with Tcf3 and Tcf4 in Th9 cells. In addition, RNA‐sequencing, chromatin immunoprecipitation, and transient reporter assay reveal that Tcf3 and Tcf4 bind to the promoter region of the Il9 gene to suppress its expression, and that Id1 inhibits their function, leading to Th9 differentiation. Finally, Id1‐deficient Th9 cells ameliorate airway inflammation in an animal model of asthma. Thus, Id1 is a transcription factor that plays an essential role in Th9 cell differentiation by inhibiting Tcf3 and Tcf4.
Conductive Passivator and Dipole Layer Mixture Enabling High‐Performance Stable Perovskite Photoelectrode‐Based Solar Water Splitting
Authors: Yun Juwon , Lee Hyungsoo , Park Young Sun , Jeong Wooyong , Jeong Chang‐Seop , Lee Junwoo , Lee Jeongyoub , Tan Jeiwan , Ma Sunhil , Jang Gyumin , Lee Chan Uk , Moon Subin , Im Hayoung , Lee Soobin , Yee Dong‐Yub , Kim Ji‐Hee , Moon Jooho 
Published: October 2023

AbstractRecently, lead halide perovskites have attracted significant attention as promising absorber materials for photoelectrochemical (PEC) solar water splitting. However, charge‐accumulation‐induced ion migration at the interface causes perovskite degradation and efficiency loss. To suppress the charge accumulation and improve the PEC performance of the perovskite photoanode, a simple interface engineering is proposed by decorating the SnO2/perovskite interface with a mixture of polyethylenimine ethoxylated (PEIE) and chlorobenzenesulfonic acid (CBSA). The mixed CBSA+PEIE treatment effectively passivates the oxygen vacancies in SnO2 and adjusts the band alignment between SnO2 and the perovskite. The synergistic effects of the mixture treatment facilitate an effective carrier extraction at the SnO2/perovskite interface, enhance the PEC performance, and improve the stability of the device. The perovskite photoanode exhibits an impressive applied bias photon‐to‐current efficiency of 12.9% with an outstanding durability for 225 h. Furthermore, an unbiased solar water splitting is achieved using all the perovskite photoelectrodes, resulting in a remarkable unassisted solar‐to‐hydrogen efficiency of 10.9% and a continuous 22 h stable operation.
Novel compound heterozygous ATP1A2 variants in a patient with fetal akinesia/hypokinesia sequence
Authors: Furukawa Shogo , Kato Mitsuhiro , Nomura Toshihiro , Sumitomo Noriko , Yoneno Shota , Nakashima Mitsuko , Saitsu Hirotomo 
Published: October 2023

AbstractATP1A2 encodes a subunit of sodium/potassium‐transporting adenosine triphosphatase (Na+/K+‐ATPase). Heterozygous pathogenic variants of ATP1A2 cause familial hemiplegic migraine, alternating hemiplegia of childhood, and developmental and epileptic encephalopathy. Biallelic loss‐of‐function variants in ATP1A2 lead to fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies, resulting in fetal death. Here, we describe a patient with compound heterozygous ATP1A2 variants consisting of missense and nonsense variants. He survived after birth with brain malformations and the fetal akinesia/hypokinesia sequence. We report a novel type of compound heterozygous variant that might extend the disease spectrum of ATP1A2.
Altered sleep architecture in children and adolescents with Down syndrome
Authors: Gardner Kelly J. , Wang Wei , Klerman Elizabeth B. 
Published: October 2023

AbstractObjectiveChildren with Down syndrome (DS) may experience changes in sleep architecture (i.e., different sleep stages) that then affect waketime functioning, including learning, mood, and disruptive behavior. For designing and testing interventions, it is important to document any differences in sleep architecture in children with DS with and without co‐occurring diagnoses, including neuropsychiatric diagnoses and obstructive sleep apnea (OSA).MethodsA retrospective cohort study was performed at Massachusetts General Hospital for children and adolescents with DS who underwent polysomnography (PSG) between August 2016 and July 2022. Patient data collected from the electronic medical record included diagnoses, age at PSG, and PSG report. Statistical analysis included unpaired T tests to test hypotheses about differences in sleep architecture within age groups, and differences between children with DS and a co‐occurring diagnosis. One way ANOVA was used to determine statistical significance of OSA severity within patients with DS.ResultsWhen compared by age group, those with DS had negative changes in sleep architecture (e.g., less sleep and more wake) when compared to normative data. Within this cohort, having a co‐occurring diagnosis of autism resulted in further, negative effects on sleep architecture. 89% of those with DS had diagnosed OSA but only those with severe OSA experienced negative effects on sleep architecture.ConclusionAge is an important covariate when studying the sleep of children with DS and neurotypical children. Studies are needed to test whether minimizing the observed differences in sleep architecture will translate to improved learning, mood, and behavioral outcomes, and how treating OSA affects sleep architecture.
Palladium‐Catalyzed Cycloisomerization of 1,6‐Allene‐Ene via [1,8]‐Sigmatropic Hydrogen Shift of Allylic C−H
Authors: Chen Can , Tian Zhe , Liang Wanjie , Guo Jintao , Xiao Ping , Wang Zhenlei , Zhang Lizhi , Liu Qing , Liu Hui 
Published: October 2023

AbstractA ligand‐free palladium‐promoted [1,8]‐sigmatropic hydrogen shift reaction of 1,6‐allene‐ene was reported, which went through an intramolecular Ene cyclization using base as a hydrogen shuttle. Notably, the transformation could realize the HAT process via the hydrogen shift from an old allylic C−H bond to a new one in the presence of oxidant, between which have low BDE distinction. The mild reaction conditions, high atom economy and good chemo/regioselectivity proved the valuable of this strategy. The control experiments using acetone‐D6/D2O proved that neither solvent nor water were involved in the cycloisomerization process and HAT process was more convincible. The target products could achieve more valuable molecules via convenient synthetic transformation.
Synthesis and characterization of green urethane non‐isocyanate from oleic acid for wood composite application
Authors: Ghozali Muhammad , Bakhri Samsul , Triwulandari Evi , Restu Witta Kartika , Meliana Yenny , Haryono Agus , Septiyanti Melati , Solihat Nissa Nurfajrin , Lee Seng Hua , Fatriasari Widya , Antov Petar 
Published: October 2023

AbstractConventional polyurethane (PU) is usually synthesized by a reaction between isocyanate and polyol. The use of isocyanate compounds is associated with significant health and environmental problems. Therefore, it is necessary to develop an environmentally friendly alternative method for manufacturing PUs without isocyanate routes. The aim of this research work was to synthesize green urethane from oleic acid, which included the following three stages: the synthesis of epoxidized oleic acid (EOA), the synthesis of carbonated oleic acid (COA), and the synthesis of green urethane from oleic acid (UOA). The resulting product was characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) analyses, and by determining the iodine number, oxirane number, and hydroxyl value. The results of FTIR and NMR showed that EOA was successfully synthesized. The optimum COA synthesis process was obtained on TBAB catalyst usage of 1% (wt/wt) at 140°C for 48 h with a 500‐rpm stirring rate and CO2 gas flow rate of 0.2 mL/min with the resulting COA oxirane value of 0.00. The optimum condition of UOA synthesis through the aminolysis process resulted in the use of LiCl of 19.8% (wt/wt) at 70°C for 3 h with a stirring speed of 1200 rpm with a UOA hydroxyl number generated of 237.93 mg/mL.
Discovery of novel benzimidazole acyclic C‐nucleoside DNA intercalators halting breast cancer growth
Authors: Abd Al Moaty Mohamed N. , El Kilany Yeldez , Awad Laila Fathy , Ibrahim Nihal Ahmed , Abu‐Serie Marwa M. , El‐Yazbi Amira , Teleb Mohamed 
Published: October 2023

AbstractBreast cancer continues to be the most frequent cancer worldwide. In practice, successful clinical outcomes were achieved via targeting DNA. Along with the advances in introducing new DNA‐targeting agents, the “sugar approach” design was employed herein to develop new intercalators bearing pharmacophoric motifs tethered to carbohydrate appendages. Accordingly, new benzimidazole acyclic C‐nucleosides were rationally designed, synthesized and assayed via MTT (3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide) assay to evaluate their cytotoxicity against MCF‐7 and MDA‐MB‐231 breast cancer cells compared to normal fibroblasts (Wi‐38), compared to doxorubicin. (1S,2R,3S,4R)‐2‐(1,2,3,4,5‐Pentahydroxy)pentyl‐1H‐5,6‐dichlorobenzimidazole 7 and (1S,2R,3S,4R)‐2‐(1,2,3,4,5‐pentahydroxy)pentyl‐1H‐naphthimidazole 13 were the most potent and selective derivatives against MCF‐7 (half‐maximal inhibitory concentration [IC50] = 0.060 and 0.080 µM, selectivity index [SI] = 9.68 and 8.27, respectively) and MDA‐MB‐231 cells (IC50 = 0.299 and 0.166 µM, SI = 1.94 and 3.98, respectively). Thus, they were identified as the study hits for mechanistic studies. Both derivatives induced DNA damage at 0.24 and 0.29 μM, respectively. The DNA damage kinetics were studied compared to doxorubicin, where they both induced faster damage than doxorubicin. This indicated that 7 and 13 showed a more potent DNA‐damaging effect than doxorubicin. Docking simulations within the DNA double strands highlighted the role of both the heterocyclic core and the sugar side chain in exhibiting key H‐bond interactions with DNA bases.
Effect of direct voltage induction by low‐frequency security systems on neurostimulator lead
Authors: Ardeshirpour Yasaman , Cohen Ethan D. , Seidman Seth J. , Taddese Biniyam , Zaidi Tayeb , Bassen Howard 
Published: October 2023

AbstractLow‐frequency (LF) security systems, such as antitheft electronic article surveillance (EAS) gates emit strong magnetic fields that could potentially interfere with neurostimulator operation. Some patients reported pain and shocking sensations near EAS gates, even after they turned off their pulse generator. To investigate the direct voltage induction of EAS systems on neurostimulator leads, we evaluated voltages induced by two EAS systems (14 kHz continuous wave or 58 kHz pulsed) on a 40 cm sacral neurostimulator lead formed in a circular loop attached to a pulse generator that was turned off. The lead and neurostimulator were mounted in a saline‐filled rectangular phantom placed within electromagnetic fields emitted by EAS systems. The measured voltage waveforms were applied to computational models of spinal nerve axons to predict whether these voltages may evoke action potentials. Additional in vitro testing was performed on the semicircular lead geometry, to study the effect of lead geometry on EAS induced voltages. While standard neurostimulator testing per ISO 14708‐3:2017 recommends electromagnetic compatibility testing with LF magnetic fields for induction of malfunctions of the active electronic circuitry while generating intended stimulating pulses, our results show that close to the EAS antenna frames, the induced voltage on the lead could be strong enough to evoke action potentials, even with the pulse generator turned off. This work suggests that patient reports of pain and shocking sensations when near EAS systems could also be correlated with the direct EAS‐induced voltage on neurostimulator lead.