bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferences for risks and benefits of treatment outcomes for chronic low back pain: Choice‐based conjoint measure development and discrete choice experiment
Authors: Wilson Leslie , Denham Alina , Ionova Yelena , O'Neill Conor , Greco Carol M. , Hassett Afton L. , Hanmer Janel , Shaikh Sana , Wolf Mehling , Berven Sigurd , Williams David , Ma Yanlei , Lotz Jeffrey , Zheng Patricia 
Published: December 2023

AbstractIntroductionUnderstanding individual patient preferences for chronic low back pain (cLBP) outcomes is essential for targeting available therapeutic options; yet tools to elicit patient outcome preferences are limited.ObjectiveTo develop and test a choice‐based conjoint (CBC) measure, commonly used in behavioral economics research, to elicit what outcomes patients with cLBP want to achieve and avoid.DesignWe developed a survey‐based CBC measure to allow patients to make risk/benefit trade‐off choices between possible treatment outcomes. After extensive literature, clinician, and patient input, our measure included seven attributes: fatigue, anxiety/depression, difficulty thinking/making decisions, pain intensity, physical abilities, change in pain, and ability to enjoy life despite pain. Random‐parameters logit models were used to estimate strength of preferences, and latent class analysis was used to identify patient characteristics associated with distinct preference.SettingOnline study using the Sawtooth web‐based platform.ParticipantsTwo hundred eleven individuals with cLBP recruited from online advertising as well as at clinical sites across multiple academic and private institutions.InterventionsNot applicable.ResultsThe most valued outcome was the highest level of physical activity (β = 1.6–1.98; p < .001), followed by avoiding cognitive difficulties (β = −1.48; p < .001). Avoidance of severe pain was comparable to avoiding constant fatigue and near‐constant depression/anxiety (β = −0.99, −1.02); p < .001). There was an association between preferences and current pain/disability status; patients with higher pain had a stronger preference to avoid severe pain, whereas those with higher disability have stronger preferences for achieving physical activity. The latent class analysis identified two distinct groups: (1) more risk‐seeking and willing to accept worse outcomes (56%); and (2) more risk‐averse with a stronger preference for achieving maximum benefits (44%).ConclusionsOur study illuminated cLBP patient preferences for treatment outcomes and heterogeneity in these preferences. Patients stressed the importance of reaching high physical activity and avoiding cognitive declines, even over a desire to avoid pain. More work is needed to understand patient preferences to aid informed, shared decisions.
Influence of rotating dielectric barrier on discharge characteristics in multi‐needle‐plate DBD
Authors: Yu Guanglin , Peng Bangfa , Jiang Nan , Wang Ronggang , Sun Haoyang , He Junwen , Shang Kefeng , Lu Na , Li Jie 
Published: December 2023

AbstractEnhancing discharge energy in dielectric barrier discharge (DBD) is vital for various applications. This study establishes a theoretical formula for predicting enhanced discharge in multi‐needle‐plate (MP) DBD, accounting for factors like needle count, rotation speed, and voltage frequency. Experiments validate the formula's accuracy, showing that precisely matched parameters result in enhanced discharge power, heightened streamer luminosity, and curved streamer channels. Lissajous figures in MP DBD exhibit elliptical shapes due to residual discharges during voltage fall. Statistical analysis of current pulses and discharge images confirms that dielectric plate rotation increases discharges and extends their duration during voltage fall. Numerical simulations highlight surface charge movement's role in enhancing the electric field and affecting streamer propagation direction in the air gap.
The Skin-Brain Connection and Pleasant Touch as Supportive Care for Psychocutaneous Disorders
Authors: Ferreira Bárbara Roque , Aguirre Claudia C. , Rapoport-Hubschman Nathalie , Adewuya Abiodun O. , Canchy Ludivine , Morizet David , Vincenzi Francesca , McGlone Francis P. 
Published: December 2023

Abstract
Psychodermatology is a subdiscipline of dermatology at the intersection of dermatology, psychiatry, and psychology. In dermatology clinical practice, patients may present with skin disease that affects their mental health, or skin disorders induced or worsened by psychological/psychiatric problems so there is a need for specialised education of dermatologists, as well as multidisciplinary teams, to achieve better management of these patients. Understanding the interaction between the central nervous system and the skin underlying psychocutaneous disorders could help identify alternative therapies that may improve patient well-being. The concept of pleasurable touch has received increasing attention following the discovery of C-tactile (CT) fibres. While afferent C-fibre stimulation is usually associated with pain, temperature, or itch, CT-fibres are stimulated optimally by a stimulus not in the nociceptor range but by a gentle, low-force stroking. As this affective touch may counteract unpleasurable sensations, such as pain and itch, and elicit positive feelings, the potential benefits of gentle touch and massage are interesting for dermatological, especially psychocutaneous, disorders. Here we provide an overview of the skin-brain connection to help understand the benefits of touch and massage, as illustrated with studies on atopic dermatitis and burns, as an adjunct to dermatological treatment for improving patient well-being and optimising treatment outcomes.
Preparation of Cellulose Nanofibrils with the Pretreatments using Inexpensive Protic Ionic Liquids based on Dimeric Oxalic Acid Anions
Authors: Zhu Deqin , Xu Xiaoxiao , Liu Jingjing , Lan Wenbo , Wei Ligang , Li Kunlan , Liu Na , An Qingda , Shao Guolin , Zhai Shangru 
Published: December 2023

AbstractPreparation of cellulose nanofibrils (CNFs) with the pretreatments using alkanolamine‐based protic ionic liquids (PILs) with dimeric oxalic acid anions ([(HOA)(H2OA)]−) was fully investigated. The cation type [ethanolamine ([MEA]+), diethanolamine ([DEA]+), triethanolamine ([TEA]+)], and water addition greatly influenced the CNF yields. Under the pretreatment conditions of 110 °C and 3 h, the CNF yields with different PIL‐based systems followed the order: [MEA][(HOA)(H2OA)]>[DEA][(HOA)(H2OA)]>[TEA][(HOA)(H2OA)], similar to their swelling capacities. The highest CNF yield of 85.0 % was obtained after the pretreatment with [MEA][(HOA)(H2OA)]‐water containing 30 wt % PILs. The optimal pH range of PILs‐water was 1.10–1.15. The good recyclability indicated that these inexpensive PILs can be employed as a simple and efficient pretreatment system for preparing CNFs. The physicochemical properties of the prepared CNFs were greatly changed by varying the PILs’ pretreatment systems. The thermal stability of CNFs was intimately connected with the crystalline structures and hydrogen bonding modes.
Enhanced Quantum Transport in Nitrogen‐substituted Dibenzo[a,e]cyclooctatetraene
Authors: Ghosh Angsula , Chaudhuri Puspitapallab 
Published: December 2023

AbstractStable [8]Annulene‐based hydrocarbons have gained significant attention recently for their potential applications in the development of responsive materials. These hydrocarbons consist of an eight‐membered carbon ring, which imparts them with exceptional stability and structural simplicity. In this study, we systematically replaced one or more carbon atoms at various positions within the dibenzo[a,e]cyclooctatetraenes (dbCOT) with nitrogen atoms and conducted a detailed theoretical investigation to comprehend their characteristics within the realm of single‐molecular electronics. Utilizing DFT, we systematically examined the structural features, energetics, and several electric and spectroscopic properties of original, reduced, and nitrogen‐substituted dbCOTs. The natural singlet dbCOT exhibits a symmetric tub‐shaped molecular structure, while the triplet configuration adopts a planar and symmetric structure, with the former demonstrating greater energetic stability. The substitutions of carbon with nitrogen atoms affect the structural symmetry in different forms, depending on the position and bonding properties of the nitrogen atoms. Most of the substituted configurations, in comparison to natural dbCOT, exhibit absorption of UV‐Vis radiation at longer wavelengths. The reduction in the HOMO‐LUMO gap results in enhanced electrical conductivity in substituted‐dbCOTs, potentially advantageous for technological applications. Notably, the spatial orientation of dbCOTs with respect to the leads exerts significant influence on the charge transfer process.
Preparation of CO2‐activated Porous Graphene for Enhancing the Electrochemical Hydrogen Storage Properties of Co9S8 Material
Authors: Jia Hongsheng , Li Siqi , Wang Yubo , E Yuanlong , Han Miao , Su Yugang 
Published: December 2023

AbstractIn this work, Co9S8 hydrogen storage material was synthesized by mechanical alloying. To improve the electrocatalytic activity and conductivity of Co9S8, a series of porous reduced graphene oxide (PRGO) materials were fabricated via a facile CO2 activation treatment of RGO at different processing times. The composites of Co9S8 doping with different amount of PRGO were manufactured through ball milling. During the electrochemical hydrogen storage test, the porous Co9S8+PRGO exhibited higher discharge capacity than Co9S8+NRGO and conventional Co9S8. Moreover, the CO2 activation time and additive amount of PRGO had significant impact on the electrochemical properties of Co9S8. Ultimately, the electrode of 6 wt.% PRGO‐2 modified Co9S8 attained the optimum discharge capacity of 653 mAh/g. The special porous structure and high specific surface area of porous graphene could provide more electrochemical active sites and facilitate the hydrogen diffusion. After PRGO modification, the cycling stability, high‐rate dischargeability (HRD) and kinetic properties of Co9S8 were also enhanced. It can be concluded that porous graphene possesses better effect than conventional graphene in improving the performance of hydrogen storage alloy.
Effect of Chemical Modification of Melicoccus Bijugatus Jacq Starch on the Fabrication of Poly(lactic acid)/Starch Films
Authors: Ortiz‐Fernández Alejandro , Huchin‐Puc Karla P. , Pérez‐Pacheco Emilio , Canto‐Pinto Jorge C. , Estrada‐León Raciel J. , Chim‐Chi Yasser A. , Moo‐Huchin Víctor M. , Ríos‐Soberanis Carlos R. , Pérez‐Padilla Yamile , Dzul‐Cervantes Mario A. A. 
Published: December 2023

AbstractThis study presents the characteristics resulting from the modification of the Melicococcus bijugatus jacq (huaya) with hexamethyl diisocyanate (HDI) and epoxidized avocado oil (AO) by the one‐step method within situ formation of peracetic acid (PA). HDI‐modified huaya starch and epoxidized AO present chemical characteristics that, according to the literature, improve the compatibility between polylactic acid (PLA) and starch when used to prepare biodegradable films according to the proposed reaction mechanism. The FTIR analysis confirmed that the grafting reaction of HDI onto the surfaces of the huaya starch granules and the epoxidation of the avocado oil took place. Peaks corresponding to vibrations of ‐NCO and ‐NH functional groups and vibrations of epoxy groups are present. The degradation profiles of the thermogravimetric analysis showed that more energy is required to initiate degradation after modification of the compounds. Scanning electron microscopy results showed effects on the huaya starch granules′ surface after the modification with HDI and a change in size. These results suggest compatibilization between the carbonyl groups, like those in the polylactic acid, the epoxy groups of the modified oil, and the isocyanate groups of the functionalized starch.
Molecular Self‐Assembly of Au Nanoparticles on a Porous Cellulose Membrane Template for Highly Sensitive Colorimetric Detection of Glucose
Authors: Wang Fen , Xia Jian , Tang Cheng , Xing Langman , Luo Xiaogang 
Published: December 2023

AbstractA sensitive glucose colorimetric detection system (Au@QCM) based on quaternized cellulose membrane (QCM) and enzyme‐mimicking Au nanoparticles (AuNPs) was successfully developed via a simple molecular self‐assembly strategy. The positively charged QCM functioned as a template to guide the negatively charged citric acid‐reduced AuNPs uniformly distributed on the surfaces along the pore walls of its porous structure, and thus gave AuNPs an ordered interconnected three‐dimensional network. This electrostatic interaction could effectively prevent the aggregation of the AuNPs and greatly increase their exposed surface area, thus endow the Au@QCM with highly active catalytic properties towards glucose oxidation with glucose oxidase (GOx). The experimental studies showed that the color change of redox indicator 3,3′,5,5′‐tetramethylbenzidine (TMB) can be clearly observed with naked eyes and the absorbance of the oxidized TMB (at 653 nm) was directly proportional to the concentration of glucose. Au@QCM could achieve a sensitive glucose detection with a limit of detection of 0.55 μM and linear response in the range of 0.01–0.5 mM. Besides, it also had good applicability in real samples detection and excellent selectivity to glucose. This novel detection system significantly improved detection performance compared to previous work based on cellulose‐based strips loaded with GOx and horseradish peroxides.
Supported Nickel‐based Catalysts for Heterogeneous Hydrogenation of Aromatics
Authors: Wang Rong , Zhang Min , Zhang Jie , Yang Jing‐He 
Published: December 2023

AbstractAromatic hydrocarbons are carcinogenic and can induce mutations in living organisms, posing a threat to the ecological environment and human life and health. Catalytic hydrogenation of aromatics to reduce the saturation of aromatics not only reduces their toxicity, but also greatly increases their potential value. Compared with the unsupported catalysts with only active components, the supported metal catalysts have higher catalytic activity and better selectivity, the catalytic activity of the hydrogenation reaction depends on the metal active phase and catalyst support. On metal/acid catalysts, the metal active center and nearby acid sites are involved in the conversion of aromatics, the active hydrogen leaking from the metal center can hydrogenate the adsorbed aromatics at the acid site. This paper reviews the recent research progress of nickel‐based catalysts for aromatic hydrocarbon catalytic hydrogenation and discusses the development prospects and challenges faced by non‐precious metal catalysts. In addition, the sulfur tolerance and hydrogen storage properties of catalysts for aromatics are reviewed.
Determination of Available Iron Species in Soil by Differential Pulse Voltammetry
Authors: Gong Liangyu , Wang Lin , Ma Yingjun , Wang Jie , Ma Chuanli , Xuan Cuijuan , Xu Wenhao , Lü Xuerong , You Runze , Su Linghao 
Published: December 2023

AbstractThe available metal species are significant for the growth and development of plants. Thus, it is important to detect the content of available metal species in soil at real‐time. Available iron in soil used to be determined by atomic absorption spectrometry or inductive coupled plasma emission spectrometer (ICP) method, which is quite expensive and not easy to operate, especially for farmers. This paper reports a rapid electrochemical method only by applying an electrochemical workstation equipment. Compared to stripping voltammetry method, differential pulse voltammetry (DPV) in this work can detect the available iron species accurately just by directly using the soil extraction solution and does not need the acidic digestion procedure. The DPV strategy we adopted in this work has the advantages of convenience, rapidity and high precision, and can reach the measurement level of ICP method.
Chemistry of 3,5‐Dichloro‐4H‐1,2,6‐thiadiazine‐4‐thione
Authors: Kalogirou Andreas S. , Kourtellaris Andreas , Koutentis Panayiotis A. 
Published: December 2023

AbstractThionation of 3,5‐dichloro‐4H‐1,2,6‐thiadiazin‐4‐one with P2S5 affords 3,5‐dichloro‐4H‐1,2,6‐thiadiazine‐4‐thione (17 %) and 4,5‐dichlorothieno[2,3‐c:5,4‐c′]bis([1,2,6]thiadiazine) (13 %) that forms via an isolable but highly reactive 1,2‐dithiine intermediate. An independent synthesis of the 4,5‐dichlorothieno[2,3‐c:5,4‐c′]bis([1,2,6]thiadiazine) was attempted via (2E,5E)‐2,5‐bis[(chlorothio)imino]‐2,5‐dihydrothiophene‐3,4‐dicarbonitrile, the chemistry of which was briefly investigated. Thiadiazine‐4‐thione reacts with diazoacetate and dimethylsulfonium dicyanomethylide to form the expected ylidenes, and undergoes a Diels‐Alder reaction with 2,3‐butadiene to give a spirocyclic 3,6‐dihydro‐2H‐thiopyran. Treating the thione with Ph3P (1 equiv) affords {3,4‐dicyano‐5‐[(triphenyl‐λ5‐phosphaneylidene)amino]thien‐2‐yl}carbonimidoyl dicyanide and 2‐[(3,5‐dichloro‐4H‐1,2,6‐thiadiazin‐4‐ylidene)amino]‐5‐[(triphenyl‐λ5‐phosphaneylidene)amino]thiophene‐3,4‐dicarbonitrile, the structure of which was supported by X‐ray crystallography. The reaction mechanism as well as independent syntheses of both products were investigated.
Exploration of N‐(6‐Indazolyl) benzenesulfonamide Derivatives as Potential Antioxidants and Antimicrobial Agents: Integrating Synthesis, In Silico Docking, and Bioactivity Profiling
Authors: Yadav Mithlesh , Rao Rekha , Kumar Sunil , Kapoor Archana 
Published: December 2023

AbstractA new series of N‐(1‐(2‐chloropyrimidin‐4‐yl)‐1H‐indazol‐5‐yl) benzenesulfonamide derivatives (4 a–i) and N‐(1‐(2‐chloropyrimidin‐4‐yl)‐6‐ethoxy‐1H‐indazol‐5‐yl) benzenesulfonamide derivatives (5 a–i) was synthesized via reduction of 1‐(2‐halopyrimidin‐4‐yl)‐5‐nitro‐1H‐indazole (3) with SnCl2 followed by reaction with various aryl sulphonyl chlorides in pyridine. The structures were confirmed using IR, 1H‐NMR, 13C‐NMR, and mass spectral methods. Compounds 4 a–i and 5 a–i were evaluated for antifungal and antibacterial activities against Gram‐negative and Gram‐positive bacteria. They also exhibited antioxidant potential in DPPH (IC50=0.094‐0.467 μmol/ml) and ABTS assays (IC50=0.101–0.496 μmol/ml). Remarkably, N‐(1‐(2‐chloropyrimidin‐4‐yl)‐1H‐indazol‐5‐yl)‐2‐nitrobenzenesulfonamide displayed the highest antibacterial activity, while N‐(1‐(2‐chloropyrimidin‐4‐yl)‐1H‐indazol‐5‐yl)‐4‐methoxybenzenesulfonamide showed excellent antifungal potential. Compound N‐(1‐(2‐chloropyrimidin‐4‐yl)‐1H‐indazol‐5‐yl)‐2‐nitrobenzenesulfonamide exhibited the most significant antioxidant activity. In this study, molecular dynamics simulations were utilized to rigorously examine the stability of ligand‐protein complexes, demonstrating a consistent and robust binding of the most potent compound within the target proteins′ binding sites. Computational assessments were further employed to predict the drug‐likeness and ADMET properties of the synthesized compounds. The results unequivocally confirmed the remarkable antioxidant and antimicrobial potential of all derivatives, a finding substantiated by comprehensive molecular docking analyses that revealed intricate interactions involving hydrogen bonds, electrostatic forces, and hydrophobic contacts. These findings collectively provide invaluable insights into the complex molecular structure and receptor target site dynamics, laying a strong foundation for the development of novel active antioxidant and antimicrobial agents with promising pharmaceutical implications.
Biosynthesis of Copper Nanoparticles Using Aqueous Pisa Plant Leaf Extracts: Antimicrobial Activities and Catalytic Application for Xanthene Synthesis
Authors: Kadam Avdhut , Survase Avinash , Kamble Santosh 
Published: December 2023

AbstractA simple, efficient and environmentally benign approach has been investigated for synthesis of copper nanoparticles using Actinodaphnehookeri (Pisa) plant leaf extract as a reducing agent. The synthesized copper NPs showed antimicrobial activity against pathogenic Gram‐positive and Gram‐negative microbial infections, also showed the catalytic activity (15 mol%) for synthesis of xanthenes with high TONs and TOFs. It's interesting that this catalyst quantitatively recovered from the reaction medium and recycled up to five cycles, and there was no noticeable loss of catalytic performance.
Study of the Influence of the Process Parameters in the Characteristics of Silver‐loaded Zeolite Complexes
Authors: Lopes Aline C. , Klosowski Ana B. , Ferrari Priscileila C. , Esmerino Luis A. , Olivato Juliana B. 
Published: December 2023

AbstractZeolite has a great capacity of adsorption and ion exchange. Silver ions are impregnated into the zeolite matrix by ion exchange, which results in the formation of an antimicrobial complex. By using a factorial design, this study explores the influence of pH, temperature, and silver nitrate concentration on the characteristics of ZeAg complexes. The ZeAg8 complex, produced with the factors of [AgNO3] of 4000 mg/L, pH 5 and T 45 °C showed promising results, showing antimicrobial activity, and maintained an original crystalline structure of the zeolite after the experimental conditions. Experimental design analysis showed that lower pH and temperature favored larger particle diameter and induce disruption of the crystalline structure of the zeolite. Silver ions impregnation into zeolite under specific conditions create a potential antimicrobial complex for wound dressings, promoting tissue regeneration and healing while preventing potential complications associated with silver treatment.
Resource allocation and growth strategies in a multi‐plant firm: Kanegafuchi Spinners in the early 20th century
Authors: Yamaguchi Shotaro , Braguinsky Serguey , Okazaki Tetsuji , Yuki Takenobu 
Published: December 2023

AbstractResearch SummaryUsing detailed plant‐ and individual‐level data from a major Japanese cotton spinning company in the early 20th century, we examine the within‐firm allocation of skilled human capital in conjunction with investment in physical capital, accompanying the firm's evolving strategic priorities. We show that the firm leveraged unit‐level two‐way complementarity between managerial talent and strategically important plants when the task was achieving large‐scale output and positioning for a competitive cost advantage. The task of conducting product differentiation, however, ushered in “three‐way complementarity,” where educated engineering human capital and capable managers needed to be bundled with specialized physical capital. A deeper dive into the “nano‐economics” of resource allocation reveals that educated engineers experiencing product differentiation in pioneering plants were reallocated to other plants also pursuing product differentiation.Managerial SummaryEffectively allocating critical resources, such as skilled human capital, across establishments in alignment with strategic priorities is a key managerial issue. Through an in‐depth case study of a major Japanese cotton spinning company in the early 20th century, we illustrate how the company shifted the resource allocation policy in response to different strategic management priorities. Initially, the company assigned managerial talent to larger plants requiring operational improvement, leveraging a competitive cost advantage for a standard product. Yet, as the company transitioned toward product differentiation via new production technologies, skilled engineers and plant managers were allocated together to a few selected plants initiating product differentiation. Engineers' experiences in product differentiation in those selected plants were diffused to other plants also pursuing product differentiation through their reallocations.