bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Sectional Study of Efficacy, Effectiveness, and Safety of Combination Creams (Tretinoin 0.05%, Clindamycin 3%, and Dexamethasone 0.05%) Anti-Acne – An Online Study
Authors: Tan Sukmawati Tansil , Yohanes Firmansyah  , Hendsun Hendsun  , Alicia Sarijuwita  , William Gilbert Satyanegara  , Joshua Kurniawan  , Dean Ascha Wijaya  
Published: January 2024

Background: Acne vulgaris is a common skin condition that causes blackheads, whiteheads, and pimples. It is caused by a number of things, like too much oil, clogged pores, and inflammation. Topical combination creams are an alternative treatment for acne. They can help reduce inflammation, kill bacteria that cause acne, and stop the skin from making too much oil. Topical combination creams like retinoids, antibiotics, and steroids are all mixed together in a single cream or gel. This study talks about the effectiveness and side effects of using combination creams (tretinoin 0.05%, clindamycin 3%, and dexamethasone 0.05%) to treat acne in the short and long term (local and systemic).
Methods: This study is a survey that was done at the Sukma clinic with data from 2022 patients who were diagnosed with acne vulgaris. The survey was done on Google Forms, which is a website. In this study, different factors were looked at, such as demographics, efficacy (like reducing acne severity, making the skin brighter, getting rid of blackheads on the face, getting rid of acne scars, improving skin texture, hiding scars, minimizing facial pores, getting rid of wrinkles and dark spots), local adverse events (like burning, itching, stinging, eruptive papules, hypopigmentation, hyperpigmentation, erythema, scaling, and other), and systemic adverse events.
Results: The results of this study show that a combination of tretinoin 0.05%, clindamycin 3%, and dexamethasone 0.05% is very effective and has minimal side effects. Local symptoms only show up during the first week of taking the drug (the "sensitization phase"), and then they tend to get less common over time. The only exceptions are hyperpigmentation and hypopigmentation, which show up later because they are caused by healing acne lesions.
Conclusion: There was no direct link between the use of anti-acne combination cream drugs and the number of systemic side effects. This is because the patient had often had this happen before (constipation, GERD, and others).
Prokofiev was (almost) right: A cross-cultural investigation of auditory-conceptual associations in Peter and the Wolf
Authors: Di Stefano Nicola , Ansani Alessandro , Schiavio Andrea , Spence Charles 
Published: January 2024

AbstractOver recent decades, studies investigating cross-modal correspondences have documented the existence of a wide range of consistent cross-modal associations between simple auditory and visual stimuli or dimensions (e.g., pitch-lightness). Far fewer studies have investigated the association between complex and realistic auditory stimuli and visually presented concepts (e.g., musical excerpts-animals). Surprisingly, however, there is little evidence concerning the extent to which these associations are shared across cultures. To address this gap in the literature, two experiments using a set of stimuli based on Prokofiev’s symphonic fairy tale Peter and the Wolf are reported. In Experiment 1, 293 participants from several countries and with very different language backgrounds rated the association between the musical excerpts, images and words representing the story’s characters (namely, bird, duck, wolf, cat, and grandfather). The results revealed that participants tended to consistently associate the wolf and the bird with the corresponding musical excerpt, while the stimuli of other characters were not consistently matched across participants. Remarkably, neither the participants’ cultural background, nor their musical expertise affected the ratings. In Experiment 2, 104 participants were invited to rate each stimulus on eight emotional features. The results revealed that the emotional profiles associated with the music and with the concept of the wolf and the bird were perceived as more consistent between observers than the emotional profiles associated with the music and the concept of the duck, the cat, and the grandpa. Taken together, these findings therefore suggest that certain auditory-conceptual associations are perceived consistently across cultures and may be mediated by emotional associations.
PENGEMBANGAN MODEL LATIHAN KEBUGARAN JASMANI BERBASIS PERMAINAN ULAR TANGGA
Authors: Setyawan Gaguk Setyawan , Ro’is Achmad Fitrian , Fahturohzis Tian David 
Published: January 2024

Tujuan penelitian ini adalah untuk pengembangan model latihan kebugaran jasmani berbasis permainan ular tangga. Adapun metode yang digunakan dalam penelitian ini adalah Model penelitian dan pengembangan yang digunakan mengadopsi model penelitian dan pengembangan (RD) level 3 menurut Borg and Gall yang dikembangkan oleh Sugiyono (2015:407). Desain penelitian ini digunakan untuk mengembangkan produk berupa model latihan kebugaran jasmani berbasis permainan sebagai aktivitas belajar siswa dalam pembelajaran PJOK. Penelitian ini berfokus pada pengembangan untuk menghasilkan sebuah produk model latihan kebugaran. Teknik pemilihan sampel menggunakan purposive sampling. Sampel didasarkan pada tujuan dan ketersediaan sampel untuk pemeriksaan. Berdasarkan data, diketahui hasil penilaian para ahli memiliki rata- rata nilai (44,3) berada pada interval (37 ≤ X). Dengan begitu maka model latihan kebugaran jasmani berbasis permainan ular tangga bugarjas yang dikembangkan berada pada kategori sesuai sebagai bentuk latihan kebugaran jasmani pada materi latihan kebugaran dalam pembelajaran PJOK.
Research on a 44 Day Quasi-periodic Oscillation of Optical Bands for BL Lac S5 0716+714
Authors: Lu Lin , Sun Bin , Fang Zhen-Xing , Wan Meng , Gong Yunlu 
Published: January 2024

Abstract
By means of astronomical observation data from the 60 cm Telescope at Yunnan Observatory, optical data in the g, r, and i bands were collected for BL Lac S5 0716+714, spanning from 2017 November 10 to 2018 May 15. The original data set contains 21,396 quasi-simultaneous multiband points, with 7132 data points for each band. The Lomb–Scargle periodogram method and the weighted wavelet Z-transform method were used to search for a quasi-periodic oscillation (QPO) signal in the data. For the first time, we report a QPO signal at 44 ± 6 days with a final significance of 3.98σ. Further analysis of the spectrum index reveals that the 44 day QPO signal is most likely explained by a helical motion of a blob with velocity
β
in the jet, where the viewing angle of the emission region in the jet undergoes periodic variations. In addition, we employed the hypothesis testing method (the null hypothesis) to analyze the flux distribution and determined that a double log-normal distribution provides a better fit; thus, there may be two radiative mini-regions within a jet in this source, so this 44 day QPO signal may be superimposed on a longer-term outburst.
Disentangling the Black Hole Mass Spectrum with Photometric Microlensing Surveys
Authors: Perkins Scott E. , McGill Peter , Dawson William , Abrams Natasha S. , Lam Casey Y. , Ho Ming-Feng , Lu Jessica R. , Bird Simeon , Pruett Kerianne , Golovich Nathan , Chapline George 
Published: January 2024

Abstract
From the formation mechanisms of stars and compact objects to nuclear physics, modern astronomy frequently leverages surveys to understand populations of objects to answer fundamental questions. The population of dark and isolated compact objects in the Galaxy contains critical information related to many of these topics, but is only practically accessible via gravitational microlensing. However, photometric microlensing observables are degenerate for different types of lenses, and one can seldom classify an event as involving either a compact object or stellar lens on its own. To address this difficulty, we apply a Bayesian framework that treats lens type probabilistically and jointly with a lens population model. This method allows lens population characteristics to be inferred despite intrinsic uncertainty in the lens class of any single event. We investigate this method’s effectiveness on a simulated ground-based photometric survey in the context of characterizing a hypothetical population of primordial black holes (PBHs) with an average mass of 30M
⊙. On simulated data, our method outperforms current black hole (BH) lens identification pipelines and characterizes different subpopulations of lenses while jointly constraining the PBH contribution to dark matter to ≈25%. Key to robust inference, our method can marginalize over population model uncertainty. We find the lower mass cutoff for stellar origin BHs, a key observable in understanding the BH mass gap, particularly difficult to infer in our simulations. This work lays the foundation for cutting-edge PBH abundance constraints to be extracted from current photometric microlensing surveys.
X-Ray Observations of the Enigmatic Wolf–Rayet System θ Mus: Two’s Company but Three’s a Crowd
Authors: Skinner Stephen L. , Zhekov Svetozar A. , Güdel Manuel , Schmutz Werner 
Published: January 2024

Abstract

θ Mus is a remarkable spectroscopic binary (SB) consisting of a carbon-type Wolf–Rayet star and OV companion (WC6+O6–7V) in a ≈19 days orbit. In addition an O-supergiant is visually detected at a small offset of 46 mas and if gravitationally bound to the SB system would have an orbital period of many decades. θ Mus is X-ray bright and a nonthermal radio source as commonly observed in massive colliding wind (CW) binaries. We present new Chandra X-ray observations of θ Mus, which complement previous XMM-Newton observations. The X-ray emission consists of a cool, nearly steady, weakly absorbed plasma component with broad redshifted emission lines located in an extended region far from the SB system. Hotter plasma is also present traced by Fe xxv emission. The observed flux in the ≈2–5 keV range dropped significantly on a timescale of ≤5 yr. The flux decrease can be attributed to an increase in absorption toward the hotter plasma which is likely located in the confined wind interaction region of the short-period SB system. The X-ray emission of θ Mus is remarkably similar to the WC+O binary γ
2 Vel including carbon recombination spectral lines but both systems show unusual line centroid properties that challenge CW models.
A Large Sample of Extremely Metal-poor Galaxies at z < 1 Identified from the DESI Early Data
Authors: Zou Hu , Sui Jipeng , Saintonge Amélie , Scholte Dirk , Moustakas John , Siudek Malgorzata , Dey Arjun , Juneau Stephanie , Guo Weijian , Canning Rebecca , Aguilar J. , Ahlen S. , Brooks D. , Claybaugh T. , Dawson K. , de la Macorra A. , Doel P. , Forero-Romero J. E. , Gontcho A Gontcho S. , Honscheid K. , Landriau M. , Le Guillou L. , Manera M. , Meisner A. , Miquel R. , Nie Jundan , Poppett C. , Rezaie M. , Rossi G. , Sanchez E. , Schubnell M. , Seo H. , Tarlé G. , Zhou Zhimin , Zou Siwei 
Published: January 2024

Abstract
Extremely metal-poor galaxies (XMPGs) at relatively low redshift are excellent laboratories for studying galaxy formation and evolution in the early universe. Much effort has been spent on identifying them from large-scale spectroscopic surveys or spectroscopic follow-up observations. Previous work has identified a few hundred XMPGs. In this work, we obtain a large sample of 223 XMPGs at z < 1 from the early data of the Dark Energy Spectroscopic Instrument (DESI). The oxygen abundance is determined using the direct T
e method based on the detection of the [O iii]λ4363 line. The sample includes 95 confirmed XMPGs based on the oxygen abundance uncertainty; the remaining 128 galaxies are regarded as XMPG candidates. These XMPGs are only 0.01% of the total DESI observed galaxies. Their coordinates and other properties are provided in the paper. The most XMPGs have an oxygen abundance of ∼1/34 Z
⊙, a stellar mass of about 1.5 × 107
M
⊙, and a star formation rate of 0.22 M
⊙ yr−1. The two most XMPGs present distinct morphologies suggesting different formation mechanisms. The local environmental investigation shows that XMPGs preferentially reside in relatively low-density regions. Many of them fall below the stellar mass–metallicity relations (MZRs) of normal star-forming galaxies. From a comparison of the MZR with theoretical simulations, it appears that XMPGs are good analogs to high-redshift star-forming galaxies. The nature of these XMPG populations will be further investigated in detail with larger and more complete samples from the ongoing DESI survey.
The ALMA-QUARKS Survey: Detection of Two Extremely Dense Substructures in a Massive Prestellar Core
Authors: Mai Xiaofeng , Liu Tie , Liu Xunchuan , Zhu Lei , Garay Guido , Goldsmith Paul F. , Juvela Mika , Liu Hongli , Mannfors Emma , Tej Anandmayee , Sanhueza Patricio , Li Shanghuo , Xu Fengwei , Semadeni Enrique Vazquez , Jiao Wenyu , Peng Yaping , Baug T. , Yang Aiyuan , Dewangan Lokesh , Bronfman Leonardo , Gómez Gilberto C. , Palau Aina , Lee Chang Won , Qin Sheng-Li , Tatematsu Ken’ichi , Chibueze James O. , Yang Dongting , Lu Xing , Luo Qiuyi , Gu Qilao , Issac Namitha , Zhang Suinan , Li Pak-Shing , Zhang Bo , Tóth L. Viktor 
Published: January 2024

Abstract
Only a handful of massive starless core candidates have been discovered so far, but none of them have been fully confirmed. Within the MM1 clump in the filamentary infrared dark cloud G34.43+0.24 that was covered by the Atacama Large Millimeter/submillimeter Array (ALMA) ATOMS survey at Band 3 (∼2″, 6000 au) and the ALMA-QUARKS survey at Band 6 (∼0.″3, 900 au), two prestellar core candidates MM1-C and E1 with masses of 71 and 20 M
⊙ and radii of 2100–4400 au were discovered. The two cores show no obvious sign of star formation activities. In particular, MM1-C is a very promising massive prestellar core candidate with a total gas mass of 71 M
⊙. Within MM1-C, we detected two extremely dense substructures, C1 and C2, as characterized by their high densities of

n

H

2

∼

10

8
–
9

cm

−
3

. Moreover, evidence of further fragmentation in C2 was also revealed. We have detected the primordial fragmentation in the earliest stage of massive star formation, and we speculate that MM1-C would be the birthplace of a massive multiple system. However, we cannot fully rule out the possibility that the massive prestellar core MM1-C will just form a cluster of low-mass stars if it undergoes further fragmentation.
Constraints on Cosmological Coupling from the Accretion History of Supermassive Black Holes
Authors: Lacy Mark , Engholm Athena , Farrah Duncan , Ejercito Kiana 
Published: January 2024

Abstract
Coupling of black hole mass to the cosmic expansion has been suggested as a possible path to understanding the dark energy content of the Universe. We test this hypothesis by comparing the supermassive black hole (SMBH) mass density at z = 0 to the total mass accreted in active galactic nuclei (AGN) since z = 6, to constrain how much of the SMBH mass density can arise from cosmologically coupled growth, as opposed to growth by accretion. Using an estimate of the local SMBH mass density of ≈1.0 × 106
M
⊙ Mpc−1, a radiative accretion efficiency, η, in the range 0.05 < η < 0.3, and the observed AGN luminosity density at z ≈ 4, we constrain the value of the coupling constant between the scale size of the Universe and the black hole mass, k, to lie in the range 0 < k ≲ 2, below the value of k = 3 needed for black holes to be the source term for dark energy. Initial estimates of the gravitational-wave background (GWB) using pulsar timing arrays, however, favor a higher SMBH mass density at z = 0. We show that if we adopt such a mass density at z = 0 of ≈7.4 × 106
M
⊙ Mpc−1, this makes k = 3 viable even for low radiative efficiencies, and may exclude nonzero cosmological coupling. We conclude that, although current estimates of the SMBH mass density based on the black hole mass–bulge mass relation probably exclude k = 3, the possibility remains open that, if the GWB is due to SMBH mergers, k > 2 is preferred.
Cassini UVIS Observations of the Enceladus Auroral Footprint on Saturn in 2017
Authors: Pryor Wayne R. , Magalhães Fabiola P. , Lamy Laurent , Prangé Renée , Esposito Larry W. , Gustin Jacques , Rymer Abigail M. , Sulaiman Ali H. 
Published: January 2024

Abstract
Ultraviolet Imaging Spectrograph (UVIS) observations show the Enceladus auroral footprint on Saturn on 2017 September 14, near the end of the Cassini mission. A series of Saturn north polar auroral images were obtained by slowly slewing the Cassini spacecraft at right angles to the UVIS long slit. The images were limb-fit to improve the spacecraft geometry. Enhanced extreme-ultraviolet 88–118 nm channel emissions due to electron impact on atomic and molecular hydrogen were seen in the expected location for the Enceladus auroral footprint on five successive images spanning almost 4 hr. Enhanced emissions were also seen in simultaneously obtained far-ultraviolet 111–165 nm images in at least two of these images, with the spectral signature expected for auroral emissions. While most Cassini UVIS auroral images do not show the Enceladus auroral footprint, these 2017 images support the earlier detection of an Enceladus-linked spot on Saturn in 2008 Cassini UVIS data.
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Authors: Talib Wamidh H. , Atawneh Sally , Shakhatreh Areen Nabil , Shakhatreh Ghyda’a Nabil , Rasheed aljarrah Islam Subhi , Hamed Reem Ali , Adel banyyounes Doaa , Al-Yasari Intisar Hadi 
Published: January 2024

Cancer, a formidable disease with a significant mortality rate, continues to claim the lives of thousands of individuals annually in contemporary society. Conventional cancer therapies are notorious for their substantial adverse effects and lack of specificity. Within the context of neoplastic development, cancer hallmarks represent fundamental biological properties that cancer cells progressively acquire. A promising approach for combating cancer involves the simultaneous targeting of multiple cancer hallmarks. Plant-derived natural compounds stand out as a promising reservoir for the development of novel and more efficacious anticancer therapeutics due to their structural diversity and minimal toxicity profiles.
Garlic (Allium sativum) has garnered considerable attention for its established anti-cancer properties over the years. Within garlic, a myriad of bioactive constituents, including organosulfur compounds, flavonoids, and phenolic compounds, exhibit distinct effects on cancer cells.
The objective of this review paper is to furnish a comprehensive elucidation of the mechanisms underpinning the anticancer actions of garlic. The elucidated findings from the studies encompassed within this review not only contribute to a more profound comprehension of the anti-cancer properties of garlic but also serve as a robust foundation upon which researchers and healthcare practitioners can formulate enhanced anticancer pharmaceuticals grounded in natural garlic compounds.
Loi EGAlim : quels effets pour les consommateurs et la grande distribution ?
Authors: Bonnet Céline , Leveneur Pauline 
Published: January 2024

Cet article étudie l’effet de la loi EGAlim sur les prix et ventes des produits alimentaires. Les données IRI de janvier 2017 à février 2020 révèlent une inflation de l’ordre de 1 % durant la première année qui a suivi l’entrée en vigueur de la loi. Cependant, grâce à la méthode d’identification causale des doubles différences, nous montrons que les trois mesures de cette loi, le relèvement du seuil de revente à perte et l’encadrement en volume et en valeur des promotions, n’ont pas eu un effet significatif à long terme sur les prix des produits composant le fond de rayon des magasins, excepté sur les trois premiers mois pour les produits d’appel ciblés par le relèvement du seuil de revente à perte. De plus, nos résultats suggèrent que l’encadrement des promotions jouerait un rôle non négligeable dans l’augmentation des prix payés par les consommateurs. Classification JEL : D04, L50, Q18.
Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer
Authors: Ansari Amir , Gheysarzadeh Ali , Sharifi Ali , Mofid Mohammad Reza 
Published: January 2024

Background and purpose:
The insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) have been exhibited to have tumor suppressor effects. Despite their prognostic value in some cancers, they have not been elucidated in gastric cancer.

Experimental approach:
We collected 68 samples from patients with gastric cancer. IGFBP-3 and IGFBP-3R expression levels were evaluated with quantitative real-time polymerase chain reaction (RT-PCR) and western blotting in patients. The relationship between prognostic factors and IGFBP-3/IGFBP-3R expression was also evaluated.

Findings/Results:
Our results showed that IGFBP-3 and IGFBP-3R expression was reduced significantly in tumor tissues. We found that there was an association between the reduction of IGFBP-3 with lymph node metastasis and tumor-node-metastasis (TNM) staging. Besides, IGFBP-3R expression was associated with tumor size, lymph node metastasis, differentiation, and TNM classification. Interestingly, we presented that the downregulation of IGFBP-3R was stage-dependent. In survival analysis, our findings showed that low levels of IGFBP-3R mRNA expression exhibited a close correlation with survival rate.

Conclusion and implications:
The findings of this study showed that the expression levels of IGFBP-3 and IGFBP-3R are valuable prognostic factors. Despite the potential of IGFBP-3, IGFBP-3R plays a significant role as a prognostic factor in gastric cancer. However, these findings need to be developed and confirmed by further studies.
Oral Manifestations, Risk Factors and Management Strategies of COVID-19 Associated Mucormycosis in Tertiary Care Hospital
Authors: Goel Pankaj , Kumar Jitendra , Rai Anshul , Shakti Prateek , Chouksey Gunjan 
Published: January 2024

Background:
Mucormycosis (black fungus) is an aggressive, life-threatening infectious disease-causing infiltration and by destroying the surrounding bone and soft tissue through vascular thrombosis and subsequent tissue infarction that may reach the brain with fatal complications. Its outbreak has been assessed around the clock during the recent pandemic as post COVID-19 sequelae.

Aims:
To assess the risk factors, oral signs and symptoms, investigations, treatment and rehabilitation strategies amongst COVID-19 associated mucormycosis patients in a tertiary care hospital.

Methods and Material:
An observational, pilot study was carried out amongst 30 active or recent COVID-19 associated mucormycosis patients reporting in the Department of Dentistry of a tertiary care hospital in Bhopal over a period of 6 months. Statistical analysis was done using Kolmogorov-Smirnov test using the Statistical Package for Social Sciences, Version 16 software.

Results:
Study was done on 30 patients (80% males and 20% females) and their median age was 46 years. Predominant risk factor present was diabetes mellitus (90%) and steroid therapy (60%). Prime oral manifestations were toothache (90%), mobile teeth (83%), draining sinus (53%), palatal ulceration (43%) and para-sinusal pain (37%).

Conclusions:
Mucormycosis can cause serious oro-facial morbidity and mortality in COVID-19 patients. The current management strategy requires early diagnosis, prompt treatment and oral rehabilitation.