bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Allogeneic Stem Cell Transplant in Chronic Myeloid Leukaemia - A Single-Centre Experience from Pakistan
Authors: Rehman Jehanzeb , Hussain Fayyaz , Chaudhry Qamar un Nisa , Mehmood Syed Kamran , Khan Mehreen Ali , Shahbaz Nighat 
Published: October 2023

Objective: To determine indications and outcomes of stem cell transplant in Chronic Myeloid Leukemia in a tertiary care centre in Pakistan.
Study Design: Retrospective longitudinal study
Place and Duration of Study: Armed Forces Bone Marrow Transplant Center, Rawalpindi Pakistan, from Jan 2002 to Jan 2019.
Methodology: Retrospective analysis of all the patients who had undergone transplants for chronic myeloid leukaemia at our centre from 2002 to 2019 was done. Cases enrolled included patients of both genders and any age for whom data related to disease status and follow-up post-transplant was available. Patients with incomplete records and follow-ups were excluded from the study.
Results: Out of 73 patients, data from 53 patients was analyzed. At a median follow-up of 40 months, overall survival was 72%. Survival in patients <40 years was better (78%) compared to the >40 years (50%). Among the three conditioning regimens, Bu16Cy120 was the most commonly used (n=35, 66%) and had better overall survival (n=29, 83%) though statistical significance could not be established (p=0.172).
Conclusion: In addition to the established indications of resistance or intolerance to tyrosine kinase inhibitors for bone marrow transplant in CML, the non-availability/ affordability, young age, and lack of access to novel drugs can be included in underdeveloped countries like Pakistan.
Adverse Event Profile in Advance Hepatocellular Carcinoma treated with Sorafenib Presenting to CMH Rawalpindi
Authors: Masood Masaba , Nadeem Muhammad , Ali Aamira , Lone Tahir Manzoor , Khan Amjad , Ahmad Assam 
Published: October 2023

Objective: To look for adverse event profiles in advance of hepatocellular carcinoma treated with Sorafenib presenting to CMH Rawalpindi and study associated socio-demographic factors
Study Design: Comparative cross-sectional study
Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Dec 2020 to Nov 2021.
Methodology: Three hundred patients with diagnosed hepatocellular carcinoma in advanced stage taking Sorafenib chemotherapy for more than three months and less than one year were included in the study. Each patient was assessed for relevant adverse effects in the follow-up outpatient visits by a consultant oncologist.
Results: Out of 300 cancer patients using Sorafenib for more than three months and less than one year, 212(70.7%) patients had at least one or more adverse effects, while 88(29.3%) did not experience any adverse effects. Diarrhoea 120(40%) was the most common adverse effect, followed by rash/desquamation 110(36.7%). Advancing age was statistically significantly associated (p-value-0.001) with adverse effects among the target population.
Conclusion: A significant number of patients suffering from hepatocellular carcinoma using Sorafenib had mild to moderate adverse effects. Physicians should keep an eye on patients with advancing age for adverse effects of this medication.
Comparison Study of 18F-FDG Production Utilizing FDG Single Citrate and FDG Duo Citrate Cassette on FASTlab2 Synthesizer at AFIRI, Rawalpindi
Authors: Ahmad Mudassar , Bilal Rizwan , Slehria Atiq Ur Rehman , Jamal Ali , Mehdi Syed Ali , Ahmed Nisar 
Published: October 2023

Objective: To compare and observe the differences of 18F-FDG produced using FDG citrate and FDG duo citrate cassette on the GE Healthcare FASTlab2 Synthesizer system following standard operating parameters.
Study Design: Quasi-experimental study.
Place and Duration of Study: Armed Forces Institute of Radiology and Imaging, Rawalpindi Pakistan, from Sep 2020 to Aug 2021.
Methodology: Comparison of 18F-FDG produced using FDG citrate and FDG duo citrate cassette on FASTlab2 consists of evaluating the estimated yield uncorrected (EYUC), estimated yield decay corrected (EYDC), radiochemical purity (RCP), synthesis duration and tracer volume in both cassettes. Sixty Batches of each FDG citrate and duo citrate cassettes were utilized to obtain the required results.
Results: Results acquired by comparing the mean yield of FDG citrate and FDG duo citrate cassette were 74.98±8.92% for EYUC and 86.35±10.26% for EYDC for the FDG citrate cassette. At the same time, the mean RCP turned out to be 99.58±1.06% for the citrate cassette and 99.9±0.35 for the duo citrate cassette. The mean synthesis duration of FDG was 24.21±0.76min and 24.75±0.43min for the citrate cassette and duo citrate cassette correspondingly, and the volume of the tracer was 3.5ml for both cassettes.
Conclusion: The results obtained by comparing these two cassettes were within the range of acceptable limits as claimed by the manufacturer, with a single cassette offering more yield as compared to a duo cassette, while the radiochemical purity, pH and volume of the tracer were found to be identical in both cassettes.
Frequency of SARS-CoV-2 Antibodies in PCR-Positive COVID-19 Patients and High-Risk Exposed Subjects at Multan
Authors: Janjua Sana Iqbal , Younas Muhammad , Afzal Raja Kamran , Khan Asma , Yasmeen Farhat , Younas Muskan 
Published: October 2023

Objective: To investigate the degree of association between Reverse Transcription Polymerase Chain Reaction positivity and seroconversion after natural COVID-19 infection in Multan, City of Pakistan.
Study Design: Cross-sectional study.
Place and Duration of Study: Combined Military Hospital, Multan Pakistan from Apr 2021 to Sep 2021.
Methodology: In this study, 219 Healthcare Workers with suspected SARS-CoV-2 infection were screened via Reverse Transcription Polymerase Chain Reaction for viral genome, followed by detection of corresponding antibody response in serum samples within ten weeks of their first exposure against spike protein via Chemiluminescence immunoassay.
Results: There was a significant association between positive RT-PCR and detectable corresponding antibodies (p=0.001). However, we found no evidence of an association between age and RT-PCR positivity and between age and detectable antibodies (p=0.874 and 0.842, respectively). Furthermore, results indicated no association between gender and RT-PCR positivity and between gender and detectable antibodies (p=0.536 and 0.285, respectively).
Conclusions: It is concluded that antibody detection against SARS-CoV-2 virus spike protein is a useful laboratory tool for screening for COVID-19 infection.Keywords: Antibody test, Asymptomatic cases, COVID-19, Healthcare workers, PCR, SARS-CoV-2.
Domestic Violence in Married Women of Rawalpindi/Islamabad, Pakistan; A Mixed Method Study
Authors: Tariq Nadia , Zafar Sadia , Farhin Shehla , Rashid Farah , Jaffry Tamkeen Nishat 
Published: October 2023

Objective: To estimate the frequency of domestic violence among women of Rawalpindi/Islamabad, its associated sociodemographic risk factors, and explore its reasons.
Study Design: Mixed Method study.
Place and Duration of Study: Rawalpindi/Islamabad, Pakistan from Feb to Jul, 2021.
Methodology: Two hundred and eight married women of Rawalpindi/Islamabad were selected. Data was collected through a pre-tested structured questionnaire. A focal group discussion was carried out in a group of 10 women to explore the reasons for domestic violence, and themes were created.
Result: The mean age of the participants was 33.6±8.63 years. The frequency of verbal, physical and emotional abuse was 102(49%), 108(51.9%) and 152(73.1%), respectively. The most commonly reported verbal abuse was abusive language. Physical abuse was slapping and emotional abuse was taking decisions without the wife’s consent. There was a strong association between verbal and physical abuse with family income and women's and husbands’ education. Significant reasons for abuse were the husband not earning, unfulfilled wish for a male child, interference from in-laws and drug addiction.
Conclusion: Verbal, physical and emotional abuse were high. Women or husband education and family were significant determinants of all forms of abuse. In contrast, jobless husbands, drug addicts, interfering in-laws and unfulfilled wishes for the male children were the perceived reasons for abuse.
Islamic and Senior High Schools in School Market in Indonesia
Authors: Juhaidi Ahmad , Bainah Bainah , Tajudin Anas , Munadi Muhammad 
Published: October 2023

Madrasah and non-religious schools must compete for potential students. These two types of educational institutions compete to attract similar student markets. Therefore, this article aims to explore the strategies of madrasah aliyah (MA) and high school (SMA) in the school market in the local context. In addition, this article aims to explore the positioning, differentiation, and brand (PDB) strategies of MA and SMA in the local context. This research is qualitative. Data was collected using interviews with 16 participants: principals, vice principals, teachers, students, alums, parents, and villagers. The study found the number of MA students declined more than high school students in the past five years. Moreover, the findings of this study show that MA PDB focus on Islamic religious learning and skills is different from the market's expectations: students/parents. In contrast, the GDP chosen by SMA focuses more on academic achievement and further study by the expectations of students and parents. This research suggests that madrasahs and schools analyze market needs for sustainable education as a basis for marketing strategies. The study also suggests a study to verify the effect of PDB on enrolment intention
Pengaruh Pengawasan Terhadap Disiplin Dan Kinerja Pegawai
Authors: Sinaga Kepler , Simatupang Deimak Yosepa , Gultom Anathasya Grace 
Published: October 2023

: Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruh pengawasan terhadap disiplin dan kinerja pegawai. Lokasi penelitian adalah di Kantor Kecamatan Pangururan Kabupaten Samosir. Hipotesis penelitian ini ada 3 yaitu terdapat pengaruh pengawasan terhadap disiplin kerja pegawai , terdapat pengaruh pengawasan terhadap kinerja pegawai, terdapat pengaruh pengawasan terhadap disiplin dan kinerja pegawai, mengambil sampel 38 0rang, riset ini merupakan penelitian kuantitatif dengan menggunakan sofeware dan teknik analis data product moment, koefisien determinasi R2, uji regresi, uji T. Dan kemudian data akan dianalis dan dijelaskan secara detail.
Berdasarkan hasil analisa regresi secara keseluruhan menunjukkan nilai koefisien korelasi (R) sebesar 0,946 yang berada pada angka interpretasi interval koefisien korelasi 0,80–1,000. Hal ini berarti bahwa korelasi atau hubungan variable pengawasan terhadap kinerja pegawai di kecamatan Pangururan Kabupaten Samosirmemiliki hubungan yang sangat kuat, bersifat positif dan signifikan sehingga untuk meningkatkan kinerja pegawai, maka diperlukan variable pengawasan terhadap kinerja pegawai. Sedangkan nilai R-square atau nilai koefisien determinasi sebesar 0,896 yang berarti bahwa persentase pengaruh variabel independen (Variabel Pengawasan) terhadap variable dependen (Kinerja Pegawai) sebesar 0,896 atau variable independen mampu mempengaruhi variable dependen (Kinerja pegawai) sebesar 89,6% sedangkan selebihnya yaitu 10,4 % (100%−89,6%) dipengaruhi oleh faktor-faktor lainnya diluar penelitian ini.
Pengaruh Penerimaan Pajak Daerah Dan Retribusi Daerah Terhadap Pembiayaan Pembangunan Di Kabupaten Deli Serdang
Authors: Simangunsong Ridhon , Hutapea Andy Stepanus , Hutapea Wilda Vionasari 
Published: October 2023

Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif karena penelitian ini bertujuan untuk mengukur pengaruh pajak daerah dan retribusi daerah terhadap pembiayaan pembangunan di Kabupaten Deli Serdang, dengan teknik analisis regresi linier berganda.
Hasil penelitian secara parsial, pajak daerah berpengaruh positif dan signifikan terhadap belanja daerah Kabupaten Deli Serdang, sedangkan retribusi daerah tidak berpengaruh signifikan terhadap belanja daerah Kabupaten Deli Serdang. Setiap peningkatan pajak daerah sebesar Rp. 1.000 akan meningkatkan belanja daerah sebesar Rp. 60.270. Setiap peningkatan retribusi daerah sebesar Rp. 1.000 akan meningkatkan belanja daerah sebesar Rp. 97.703. Secara serempak variabel pajak daerah dan retribusi daerah berpengaruh signifikan terhadap belanja daerah Kabupaten Deli Serdang pada tingkat kepercayaan 95 %. Sebesar 92,90 % dari perubahan belanja daerah dapat dijelaskan oleh perubahan pajak daerah dan retribusi daerah, sedangkan sisanya sebesar 7,10 % dijelaskan oleh variabel lain yang tidak dimasukkan sebagai variabel dalam penelitian. Perbedaan antara pengeluaran belanja daerah dan penerimaan daerah Kabupaten Deli Serdang selama tahun 2005 – 2013 selalu mengalami defisit, dan jumlah defisit yang terjadi pada setiap tahun selalu meningkat. Peningkatan jumlah defisit pendapatan dan belanja daerah disebabkan adanya peningkatan belanja daerah yang tidak didukung oleh peningkatan pendapatan asli daerah dalam bentuk pajak daerah dan retribusi daerah. Selisish pengeluaran daerah dengan penerimaan pajak daerah dan retribusi daerah mengalami defisit sehingga harus dipenuhi dari pinjaman pemerintah Kabupaten Deli Serdang.
Pengaruh Revitalisasi dan Motivasi Pedagang Terhadap Efektivitas Perdagangan di Kecamatan Samarang Kabupaten Garut
Authors: Sugiharto Toni Hari , Firdaus Oktri Mohammad , Ulumudin Aceng 
Published: October 2023

Penelitian ini didasarkan pada permasalahan mengenai efektivitas perdagangan di Kecamatan Samarang Kabupaten Garut yang belum optimal yang diindikasikan belum baiknya revitalisasi dan motivasi pedagang di Kecamatan Samarang Kabupaten Garut. Penelitian ini bertujuan untuk menganalisis revitalisasi, motivasi pedagang dan efektivitas perdagangan di Kecamatan Samarang Kabupaten Garut. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskripsi analisis statistik. Populasi dan responden dalam penelitian ini adalah 584 orang dan sampelnya adalah sebanyak 85 responden dengan menggunakan teknik simple random sampling. Berdasarkan analisis data dan hasil penelitian bahwa revitalisasi dan motivasi pedagang memiliki pengaruh positif terhadap efektivitas perdagangandi Kecamatan Samarang Kabupaten Garut. Adapun temuan dilapangan salah satunya adalah terkait kegiatan ekonomi formal di pasar di Kecamatan Samarang Kabupaten Garut masih belum optimal, belum baiknya sikap pegawai terhadap pedagang pasar dan kontribusi organisasi pedagang di pasar samarang Kecamatan Samarang Kabupaten Garut masih kurang baik.
ВЫЯВЛЕНИЕ БАКТЕРИИ SALMONELLA ENTERICA В ПРОДУКТАХ ПИТАНИЯ
Authors: Бармак Сабырхан , Султанкулова Гульмира , Жолдыбаева Елена 
Published: October 2023

Сальмонеллезная инфекция стала одним из самых распространенных зоонозов в мире. Продолжающийся рост заболеваемости сальмонеллезом во многих странах, увеличение числа выделяемых от животных и людей сероваров сальмонелл, контаминация данными бактериями пищевых продуктов животного происхождения, объектов внешней среды, выдвигают эту зоонозную инфекцию в ряд важнейших не только ветеринарных, но и медицинских, экологических и социальных проблем. По заключению ВОЗ, сальмонеллез не имеет себе равных по сложности развития как эпизоотического, так и эпидемического процессов и по трудности борьбы с ним. В настоящей работе показаны результаты оценки контаминации сальмонеллой пищевых продуктов. Выделение бактерии Salmonella enterica подтверждено методами ПЦР и секвенирования гена рибосомной 16S рРНК. ДНК образцов положительные на бактерии Salmonella были секвенированы с использованием праймеров специфичных к 16S рPHK. Бактерия Salmonella enterica была выделена в 5,66% из 300 протестированных продуктов питания в 2022 г. Бактерии Salmonella enterica чаще всего выделены из мяса птицы (2,33%), за которыми следовали яйца и яичные продукты (2,0%). Контаминированными Salmonella enterica пищевыми продуктами были мясные, куриные и молочные продукты.
Online Assessments for Reflection within a Large Class: A Case Study of English for Educational Development Law Students at the University of the Western Cape
Authors: Patel Mahmoud , Braaf Norina , Chinnian Karin , Mohammed Tawffeek 
Published: October 2023

This study reports on the use of online assessments in English for an Educational Development module for law students at the University of the Western Cape, South Africa. It highlights the benefits of using the method of an online test to manage and enable learning by reflection in a large class setting. The design and development of online materials and assessment activities is based on a theoretical and conceptual framework that stems from the main schools of learning, namely behaviourism, cognitivism, and constructivism, and alternative assessment. Upon the completion of the course, a survey of 12 questions was given to 530 students to determine the benefits and challenges they experienced while completing their online test within a formative and reflective context. The adoption of e-Learning practices to enhance teaching and learning was explored and has shown its advantages. Results revealed that this method enables students to engage with learning materials, stay motivated, and test their own understanding of meaningful knowledge in the English language especially in the Law context. It is evident that the use of online methods for testing are beneficial for a large class context as in this case. It makes the learning and management thereof easier for both the learner and educator and accommodates different learning styles. Apart from the advantages, the findings of this study included some ethical and technical challenges and disadvantages of online assessments.
Peran Operator Sekolah dalam Meningkatkan Mutu Sistem Informasi Manajemen Pendidikan SDN 34/I Teratai
Authors: Ulva Devi Aulia , Fronika Stella , Yantoro Yantoro , Setiyadi Bradley 
Published: October 2023

Penelitian ini dilakukan untuk mengetahui peran operator sekolah dalam meningkatkan mutu sistem informasi manajemen pendidikan di sekolah dasar. Metode penelitian yang digunakan yakni metode penelitian kualitatif deskriptif dengan teknik pengumpulan data yaitu observasi dan wawancara. Penelitian dilakukan di SDN 34/I Teratai dengan menjadikan satu operator sekolah sebagai objek penelitian. Salah satu bagian penting dari pendidikan yakni sistem informasi manajemen. Operator sekolah berperan sebagai pengelola sistem informasi manajemen yang berpengaruh pada peningkatan mutu sekolah itu sendiri. Sistem informasi manajemen SDN 34/I Teratai dikelola dengan baik oleh ooperator sekolah, dimulai dari awal semester ganjil hingga akhir semester genap. Pengelolaan data-data yang dilakukan operator sekolah berjalan dengan baik dan tidak dapat dilakukan oleh tenaga pendidik. Operator sekolah juga mengelola data internal maupun eksternal dengan teliti, baik data kepala sekolah, guru-guru, siswa, maupun sumber daya sekolah lainnya. Operator sekolah telah memiliki kemampuan dan kompetensi yang sangat baik dalam membantu pengelolaan sistem informasi manajemen sekolah, hal ini dibuktikan dengan peraihan gelar sekolah adiwiyata tingkat nasional dan terdatanya SDN 34/I Teratai sebagai sekolah penggerak yang telah berjalan selama 2 tahun. Dengan demikian dapat disimpulkan bahwa peran operator sekolah sangat penting dikarenakan dapat meningkatkan mutu sistem informasi manajemen pendidikan di SDN 34/I Teratai Muara Bulian.
Malaysian Consumer Income and Spending Behaviour During the COVID-19 Pandemic: An Insight from Maqāṣid Al-Sharīʿah
Authors: Hisham Nur Alisya Nabila Ros , Ismail Shahrina , Syed Mohamad Sharifah Fairuz 
Published: October 2023

Purpose — Spending patterns changed during the COVID-19 pandemic due to the health crisis turning into an economic challenge. This study examines the Malaysian public’s awareness level and changes in their spending behaviour during COVID-19. It also aims to identify the spending patterns on different items based on the consumers’ income and establish whether the awareness level of maqāṣid al-Sharīʿah (objectives of Islamic law) on spending affects the public’s perception of future spending behaviour.
Design/Methodology/Approach — Quantitative approaches were implemented through questionnaire outcomes, and further analysis was carried out through the SPSS software. The survey included 420 participants, and the results were analysed using inferential and descriptive statistics such as the Chi-Square test and regression.
Findings — Important findings of this paper show that the situation following the COVID-19 pandemic led to behavioural changes in many aspects, especially in Malaysians’ spending patterns. The findings show that most items related to awareness of maqāṣid al-Sharīʿah and spending are less than 3, which means that respondents are not aware or slightly aware of the concept. Only one item related to spending more on necessities during the pandemic achieves an average of more than 3. Secondly, changes in spending behaviour are seen on all items included in the study, which means the pandemic caused various changes in the spending patterns of Malaysians. Furthermore, certain categories of items (e.g., food and groceries, meal delivery services, entertainment items, face masks/hand sanitisers/disinfectants, and internet services) have shown significant differences among income groups in this study. Finally, from the regression results, it is found that the awareness level of maqāṣid al-Sharīʿah and its impact on spending is significant for the future perception of spending.
Originality/Value — The novelty of this study comes from the concept of relating spending behaviour to maqāṣid al-Sharīʿah, especially during challenging moments such as the COVID-19 pandemic.
Practical Implications — This paper reflects the importance of enhancing the maqāṣid al-Sharīʿah concept in spending patterns, especially in Muslim-majority countries. The current research added to knowledge in regard to how consumer behaviour changed during the COVID-19 pandemic. The findings may be useful in developing marketing strategies, considering psychological elements to suit the feelings and demands of genuine customers.