bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degradable and Biocompatible Magnesium Zinc Structures for Nanomedicine: Magnetically Actuated Liposome Microcarriers with Tunable Release
Authors: Peter Florian , Kadiri Vincent Mauricio , Goyal Rahul , Hurst José , Schnichels Sven , Avital Aviram , Sela Mor , Mora‐Raimundo Patricia , Schroeder Avi , Alarcón‐Correa Mariana , Fischer Peer 
Published: February 2024

AbstractInorganic therapeutic carriers and implants should not only be biocompatible, but should also degrade under physiological conditions. Ideally, the time of the degradation can be controlled, and ideally the degradation products are fully biocompatible and metabolized by the body. This proves a challenge for carriers used in nanomedicine, including microswimmers and nanorobotic systems destined for targeted delivery, as these generally require inorganic materials to enable coupling to external fields. Taking inspiration from macroscopic orthopedic implants that are made from magnesium (Mg) and zinc (Zn) and that are fully biocompatible and degradable, the growth of complex microstructures is demonstrated, including micropropellers, containing Mg and Zn. By varying the content of Mg, the corrosion time of the microstructures can be tuned from hours to over a month. Incorporation of biocompatible hard‐magnetic iron (Fe)‐platinum (Pt) permits the controlled motion of the micropropellers. The surface of the MgZn structures can be functionalized with liposomes, rendering the structures microcarriers that allow for a time‐dependent release of their cargo as a results of their degradation in aqueous environments. This suggests a powerful platform for targeted drug or gene delivery, that can be integrated with established systems for magnetic actuation and transfection.
Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes
Authors: Gomes Francisca L. , Jeong Seol‐Ha , Shin Su Ryon , Leijten Jeroen , Jonkheijm Pascal 
Published: February 2024

AbstractBlood scarcity is one of the main causes of healthcare disruptions worldwide, with blood shortages occurring at an alarming rate. Over the last decades, blood substitutes have aimed at reinforcing the supply of blood, with several products (e.g., hemoglobin (Hb)‐based oxygen (O2) carriers, perfluorocarbons (PFC)) achieving a limited degree of success. Regardless, there is still no widespread solution to this problem due to persistent challenges in product safety and scalability. In this Review, different advances are described in the field of blood substitution, particularly in the development of artificial red blood cells, otherwise known as engineered erythrocytes (EE). The different strategies are categorized into natural, synthetic, or hybrid approaches, and discuss their potential in terms of safety and scalability. Synthetic EEs are identified as the most powerful approach, and describe erythrocytes from a materials engineering perspective. Their biological structure and function are reviewed, as well as explore different methods of assembling a material‐based cell. Specifically, it is discussed how to recreate size, shape, and deformability through particle fabrication, and how to recreate the functional machinery through synthetic biology and nanotechnology. It is concluded by describing the versatile nature of synthetic erythrocytes in medicine and pharmaceuticals and propose specific directions for the field of erythrocyte engineering.
All‐Lanthanide Mechanoluminescence from Transparent Ln‐doped MgF2@Elastomer for Flexible and Stretchable Lighting and Stress Sensing
Authors: Cai Chongyang , Li Leipeng , Li Huimin , Li Pei , Li Tao , Peng Dengfeng , Yang Yanmin 
Published: February 2024

AbstractMechanoluminescent materials have gained considerable attention over the past two decades because of their ability to convert wasted mechanical actions, such as friction and compression, into useful light energy. Despite great advances in this field, host matrices that are considered for immobilizing luminescent centers to realize mechanoluminescence are limited mainly to sulfides, oxysalts, and oxysulfides to some extent. To address this shortcoming, a new series of mechanoluminescent materials, i.e., lanthanide‐doped MgF2 (Lanthanide = Yb3+,2+, Tm3+, Dy3+, Tb3+, Eu3+,2+, Sm3+, Ho3+, and Er3+) are presented. Upon stimulation with external mechanical stress, all the materials exhibit mechanoluminescence, covering the spectral range of 385 to 1000 nm. Based on this and transparent Ln‐doped MgF2@Elastomer, the potential value of these mechanoluminescent materials in dynamic pressure visualization is expanded for certain new applications, such as bungee jumping and trampolining. These findings are expected to provide valuable information to the materials community.
Microstructured Organic Cavities with High‐Reflective Flat Reflectors Fabricated by Using a Nanoimprint‐Bonding Process
Authors: Enna Takuya , Adachi Yuji , Hirao Tsukasa , Takahashi Shun , Yamamoto Yohei , Yamashita Kenichi 
Published: February 2024

AbstractThe integration of photonic microstructure into organic microcavities represents an effective strategy for manipulating eigenstates of cavity or polariton modes. However, well‐established fabrication processes for microstructured organic microcavities are still lacking. This study proposes a nanoimprint‐bonding process as a novel fabrication method for microstructured organic microcavities. This process relies on a UV nanoimprint technique utilizing two different photopolymer resins, enabling the independent fabrication of highly reflective reflectors and photonic microstructures without compromising the accuracy of each. The resulting organic microcavities demonstrate spatially localized photonic modes within dot structures and their nonlinear responses on the pumping fluence. Furthermore, a highly precise photonic band is confirmed within a honeycomb lattice structure, which is owing to the high quality factor of the cavity achievable with the nanoimprint‐bonding process. Additionally, a topological edge state is also observable within a zigzag lattice structure. These results highlight the significant potential of the fabrication method for advancing organic‐based photonic devices, including lasers and polariton devices.
Certification Grade Quantum Dot Luminescent Solar Concentrator Glazing with Optical Wireless Communication Capability for Connected Sustainable Architecture
Authors: Meinardi Francesco , Bruni Francesco , Castellan Claudio , Meucci Marco , Umair Ali Muhammad , La Rosa Marcello , Catani Jacopo , Brovelli Sergio 
Published: February 2024

AbstractEnergy sustainability and interconnectivity are the two main pillars on which cutting‐edge architecture is based and require the realization of energy and intelligent devices that can be fully integrated into buildings, capable of meeting stringent regulatory requirements and operating in real‐world conditions. Luminescent solar concentrators, particularly those based on near‐infrared emitting reabsorption‐free quantum dots, are considered good candidates for the realization of semi‐transparent photovoltaic glazing, but despite important advances in optical property engineering strategies, studies of finished devices suitable for real‐world operation are still lacking. In this paper, the first example of a fully assembled quantum dot luminescent solar concentrator‐based photovoltaic glazing is demonstrated that meets all international standards for photovoltaic and building elements. It is also shown that these devices are capable of functioning as efficient Visible Light Communication (VLC) receivers even under full sunlight, thus combining energy and wireless connectivity functions in a realistic solution for smart, sustainable buildings.
Energy‐Saving Hydrogen Production by Seawater Splitting Coupled with PET Plastic Upcycling
Authors: Liu Kesheng , Gao Xutao , Liu Chu‐Xuan , Shi Rui , Tse Edmund C. M. , Liu Fulai , Chen Yong 
Published: February 2024

AbstractDirect seawater electrolysis presents a promising route for grid‐scale green hydrogen (H2) production without reliance on scarce freshwater. However, it is severely hampered by high energy consumption (> 4.3–5.73 kWh m−3 H2) and harmful chlorine corrosion. Herein, an energy‐saving and chlorine‐free H2 production system by coupling seawater splitting and upcycling of polyethylene terephthalate (PET) waste into value‐added glycolic acid (GA) over a Pd─CuCo2O4 catalyst is reported. An ultra‐low potential of 1.15 V versus RHE is required to achieve an industry‐level current density of 600 mA cm−2, which reduces electricity cost to 2.45 kWh m−3 H2. Notably, this system maintains 1.6 A for longer than 100 h, demonstrating excellent stability. Experimental and theoretical results unveil that 1) the specific adsorption of PET‐derived ethylene glycol (EG) on Pd enhances the catalytic performance, and the downshifted d‐band center of Pd accelerates the desorption of GA to prevent over‐oxidation; 2) the strong adsorption of OH− on CuCo2O4 synergistically promotes EG electrooxidation (EGOR) and forms a negative charge layer that effectively repels Cl− by electrostatic repulsion, thus preventing chlorine corrosion. This work may provide new opportunities for H2 production and value‐added GA from vast marine resources and PET waste.
Unveiling the Strain‐induced Microstructural Evolution and Morphology‐Stretchability Correlations of Intrinsically Stretchable Organic Photovoltaic Films
Authors: Peng Zhongxiang , Li Saimeng , Zhou Kangkang , Zhang Yaowen , Li Mingfei , Li Xin , Yang Chunming , Bian Fenggang , Geng Yanhou , Ye Long 
Published: February 2024

AbstractThe progress of stretchable and wearable photovoltaics relies heavily on intrinsically stretchable active layer films. Nevertheless, there is a paucity of research clarifying the connections between their microstructure, performance, and their adaptation to large strain in polymer electronic films. The current study utilizes multiple synchrotron X‐ray scattering methods to collectively examine the correlations between morphology and stretchability, as well as the microstructural evolution induced by stretching in three sample cases of highly stretchable ternary blend films. These blends contain over 30% by weight of a polymer elastomer, such as styrene‐ethylene‐butylene‐styrene block copolymer, integrated into the high‐performance polymer:nonfullerene small molecule mixture. Specifically, the real‐time microstructural changes of these durable organic photovoltaic films with elastomers are monitored when subjected to tensile stretching through in situ synchrotron X‐ray scattering. The experiments demonstrate that polymeric elastomers can effectively lower the degree of crystallinity in films and deform the crystallites of semiconductor molecules. The elastomeric component aids in stress dispersion during stretching, thereby improving the microstructural durability of blend films. This study provides new recommendations for advancing stretchable organic optoelectronic devices.
1,4‐Aminoarylation of Butadienes via Photoinduced Palladium Catalysis
Authors: Cai Yuan , Gaurav Gaurav , Ritter Tobias 
Published: February 2024

AbstractA visible‐light‐induced, three‐component palladium‐catalyzed 1,4‐aminoarylation of butadienes with readily available aryl halides and aliphatic amines has been developed, affording allylamines with excellent E‐selectivity. The reaction exhibits exceptional control over chemo‐, regio‐, and stereoselectivity, a broad substrate scope, and high functional group compatibility, as demonstrated by the late‐stage functionalization of bioactive molecules. Mechanistic investigations are consistent with a photoinduced radical Pd(0)‐Pd(I)‐Pd(II)‐Pd(0) Heck‐Tsuji–Trost allylation cascade.
Porphyrin‐Thiophene Based Conjugated Polymer Cathode with High Capacity for Lithium‐Organic Batteries
Authors: Wu Xing , Zhou Wang , Ye Chao , Zhang Jiahao , Liu Zheyuan , Yang Chengkai , Peng Jinfeng , Liu Jilei , Gao Ping 
Published: February 2024

AbstractOrganic electrode materials are promising for next‐generation energy storage materials due to their environmental friendliness and sustainable renewability. However, problems such as their high solubility in electrolytes and low intrinsic conductivity have always plagued their further application. Polymerization to form conjugated organic polymers can not only inhibit the dissolution of organic electrodes in the electrolyte, but also enhance the intrinsic conductivity of organic molecules. Herein, we synthesized a new conjugated organic polymer (COPs) COP500‐CuT2TP (poly [5,10,15,20‐tetra(2,2′‐bithiophen‐5‐yl) porphyrinato] copper (II)) by electrochemical polymerization method. Due to the self‐exfoliation behavior, the porphyrin cathode exhibited a reversible discharge capacity of 420 mAh g−1, and a high specific energy of 900 Wh Kg−1 with a first coulombic efficiency of 96 % at 100 mA g−1. Excellent cycling stability up to 8000 cycles without capacity loss was achieved even at a high current density of 5 A g−1. This highly conjugated structure promotes COP500‐CuT2TP combined high energy density, high power density, and good cycling stability, which would open new opportunity for the designable and versatile organic electrodes for electrochemical energy storage.
Non‐Fully Conjugated Dimerized Giant Acceptors with Different Alkyl‐Linked Sites for Stable and 19.13 % Efficiency Organic Solar Cells
Authors: Yi Fan , Xiao Manjun , Meng Yongdie , Bai Hairui , Su Wenyan , Gao Wei , Yao Ze‐Fan , Qi Guangyu , Liang Zezhou , Jin Conggui , Tang Lingxiao , Zhang Rui , Yan Lihe , Liu Yuhang , Zhu Weiguo , Ma Wei , Fan Qunping 
Published: February 2024

AbstractAchieving both high power conversion efficiency (PCE) and device stability is a major challenge for the practical development of organic solar cells (OSCs). Herein, three non‐fully conjugated dimerized giant acceptors (named 2Y‐sites, including wing‐site‐linked 2Y‐wing, core‐site‐linked 2Y‐core, and end‐site‐linked 2Y‐end) are developed. They share the similar monomer precursors but have different alkyl‐linked sites, offering the fine‐tuned molecular absorption, packing, glass transition temperature, and carrier mobility. Among their binary active layers, D18/2Y‐wing has better miscibility, leading to optimized morphology and more efficient charge transfer compared to D18/2Y‐core and D18/2Y‐end. Therefore, the D18/2Y‐wing‐based OSCs achieve a superior PCE of 17.73 %, attributed to enhanced photocurrent and fill factor. Furthermore, the D18/2Y‐wing‐based OSCs exhibit a balance of high PCE and improved stability, distinguishing them within the 2Y‐sites. Building on the success of 2Y‐wing in binary systems, we extend its application to ternary OSCs by pairing it with the near‐infrared absorbing D18/BS3TSe‐4F host. Thanks to the complementary absorption within 300–970 nm and further optimized morphology, ternary OSCs obtain a higher PCE of 19.13 %, setting a new efficiency benchmark for the dimer‐derived OSCs. This approach of alkyl‐linked site engineering for constructing dimerized giant acceptors presents a promising pathway to improve both PCE and stability of OSCs.
Highly Thermally Conductive Aramid Nanofiber Composite Films with Synchronous Visible/Infrared Camouflages and Information Encryption
Authors: Han Yixin , Ruan Kunpeng , He Xiaoyu , Tang Yusheng , Guo Hua , Guo Yongqiang , Qiu Hua , Gu Junwei 
Published: February 2024

AbstractThe development of highly thermally conductive composites that combine visible light/infrared camouflage and information encryption has been endowed with great significance in facilitating the application of 5G communication technology in military fields. This work uses aramid nanofibers (ANF) as the matrix, hetero‐structured silver nanowires@boron nitride nanosheets (AgNWs@BNNS) prepared by in situ growth as fillers, which are combined to fabricate sandwich structured thermally conductive and electrically insulating (BNNS/ANF)‐(AgNWs@BNNS)‐(BNNS/ANF) (denoted as BAB) composite films by “filtration self‐assembly, air spraying, and hot‐pressing” method. When the mass ratio of AgNWs@BNNS to BNNS is 1 : 1 and the total mass fraction is 50 wt %, BAB composite film has the maximum in‐plane thermal conductivity coefficient (λ∥ of 10.36 W/(m ⋅ K)), excellent electrical insulation (breakdown strength and volume resistivity of 41.5 kV/mm and 1.21×1015 Ω ⋅ cm, respectively) and mechanical properties (tensile strength of 170.9 MPa). 50 wt % BAB composite film could efficiently reduce the equilibrium temperature of the central processing unit (CPU) working at full power, resulting in 7.0 °C lower than that of the CPU solely integrated with ANF directly. In addition, BAB composite film boasts adaptive visible light/infrared dual camouflage properties on cement roads and jungle environments, as well as the function of fast encryption of QR code information within 24 seconds.
Advancing multiproduct resin reuse for development and clinical manufacturing of an antibody‐based therapeutic
Authors: Li Hong , Rose Patricia , Rowicki Patricia , Cutler Collette , McPhee Jeffrey T. , Frey Claudia , Lemieux Linda , Pelette Gerald , Ang Joo Kok , Liu Ren , Richardson Douglas D. 
Published: February 2024

AbstractChromatography resins used for purifying biopharmaceuticals are generally dedicated to a single product. For clinical manufacturing, this can result in resin being used only for a fraction of its potential lifetime. Extending the use of resins to multiple products can significantly reduce resin waste and cost. It can also improve manufacturing flexibility in case of raw material shortage during times such as the COVID‐19 pandemic. The work presented herein describes an overarching multiproduct resin reuse (MRR) strategy, which includes a risk assessment, strategic planning, small‐scale feasibility runs, and the successful execution of the MRR strategy to support Good manufacturing practice (GMP) clinical manufacturing of an antibody‐based therapeutic. Specifically, an anion exchange (AEX) and cation exchange (CEX) MRR strategy is described. Clearance of carryover biological product is demonstrated by first cleaning the AEX and CEX manufacturing columns with sodium hydroxide to ensure inactivation and degradation of the carryover protein and followed by a blank buffer elution that is tested using various analytical methodologies to ensure reduction of the carryover protein to an acceptable level. To our knowledge, this is the first time an MRR approach has been successfully implemented and submitted to health authorities to support biologic GMP clinical manufacture.
PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells
Authors: Lebon Delphine , Collet Louison , Djordjevic Stefan , Gomila Cathy , Ouled‐Haddou Hakim , Platon Jessica , Demont Yohann , Marolleau Jean‐Pierre , Caulier Alexis , Garçon Loïc 
Published: February 2024

AbstractIntroductionLeukemogenesis is a complex process that interconnects tumoral cells with their microenvironment, but the effect of mechanosensing in acute myeloid leukemia (AML) blasts is poorly known. PIEZO1 perceives and transmits the constraints of the environment to human cells by acting as a non‐selective calcium channel, but very little is known about its role in leukemogenesis.ResultsFor the first time, we show that PIEZO1 is preferentially expressed in healthy hematopoietic stem and progenitor cells in human hematopoiesis, and globally overexpressed in AML cells. In AML subtypes, PIEZO1 expression associates with favorable outcomes as better overall (OS) and disease‐free survival (DFS). If PIEZO1 is expressed and functional in THP1 leukemic myeloid cell line, its chemical activation doesn’t impact the proliferation, differentiation, nor survival of cells. However, the downregulation of PIEZO1 expression dramatically reduces the proliferation and the survival of THP1 cells. We show that PIEZO1 knock‐down blocks the cell cycle in G0/G1 phases of AML cells, impairs the DNA damage response pathways, and critically increases cell death by triggering extrinsic apoptosis pathways.ConclusionsAltogether, our results reveal a new role for PIEZO1 mechanosensing in the survival and proliferation of leukemic blasts, which could pave the way for new therapeutic strategies to target AML cells.
Mitochondrial dynamics as a novel treatment strategy for triple‐negative breast cancer
Authors: Wang Yuechen , Harada‐Shoji Narumi , Kitamura Narufumi , Yamazaki Yuto , Ebata Akiko , Amari Masakazu , Watanabe Mika , Miyashita Minoru , Tada Hiroshi , Abe Takaaki , Suzuki Takashi , Gonda Kohsuke , Ishida Takanori 
Published: February 2024

AbstractIntroductionTriple‐negative breast cancer (TNBC), recognized as the most heterogeneous type of breast cancer (BC), exhibits a worse prognosis than other subtypes. Mitochondria dynamics play a vital role as mediators in tumorigenesis by adjusting to the cell microenvironments. However, the relationship between mitochondrial dynamics and metabophenotype exhibits discrepancies and divergence across various research and BC models. Therefore, this study aims to explore the role of mitochondrial dynamics in TNBC drug resistance and tumorigenesis.MethodsThe Wst‐8 test was conducted to assess doxorubicin sensitivity in HCC38, MDA‐MB‐231 (TNBC), and MCF‐7 (luminal). Confocal microscopy and FACS were used to quantify the mitochondrial membrane potential (ΔφM), mitophagy, and reactive oxygen species (ROS) production. Agilent Seahorse XF Analyzer was utilized to measure metabolic characteristics. Dynamin‐related protein‐1 (DRP1), Parkin, and p62 immunohistochemistry staining were performed using samples from 107 primary patients with BC before and after neoadjuvant chemotherapy (NAC).ResultsMDA‐MB‐231, a TNBC cell line with reduced sensitivity to doxorubicin, reduced ΔφM, and enhanced mitophagy to maintain ROS production through oxidative phosphorylation (OXPHOS)‐based metabolism. HCC38, a doxorubicin‐sensitive cell line, exhibited no alterations in ΔφM or mitophagy. However, it demonstrated an increase in ROS production and glycolysis. Clinicopathological studies revealed that pretreatment (before NAC) expression of DRP1 was significant in TNBC, as was pretreatment expression of Parkin in the hormone receptor‐negative group. Furthermore, low p62 levels seem to be a risk factor for recurrence‐free survival.ConclusionOur findings indicated that the interplay between mitophagy, linked to a worse clinical prognosis, and OXPHOS metabolism promoted chemotherapy resistance in TNBC. Mitochondrial fission is prevalent in TNBC. These findings suggest that targeting the unique mitochondrial metabolism and dynamics in TNBC may offer a novel therapeutic strategy for patients with TNBC.
Isolation of New Diterpenoids from the Halophyte, Vitex rotundifolia, and their Antioxidant and Anti‐inflammatory Activities
Authors: Hwan Oh Jung , Kong Chang‐Suk , Lee Jihee , Kim Eun‐Hee , Seo Youngwan 
Published: February 2024

AbstractIn this study, three diterpenoids (1‐3), including one known compound (1), were isolated from the fruits of Vitex rotundifolia and their structures were determined via spectroscopic analysis. In lipopolysaccharide‐stimulated RAW264.7 cells, these compounds dose‐dependently decreased the intracellular reactive oxygen species levels and nitric oxide production compared to those in the control cells. At 25 μM/mL, these compounds also diminished the protein expression of the pro‐inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase‐2, and interleukin‐6, with compound 3 exhibiting the most potent inhibitory effect.