bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Therapist Interventions Versus or Combined With Surgical Treatment in Nontraumatic Degenerative Meniscal Pathology: A Systematic Review and Network Meta-Analysis
Authors: Solsona-Carcas Daniel , Trenado-Molina Javier , Buesa-Estéllez Almudena , López-Royo Maria Pilar , Bellosta-López Pablo 
Published: January 2024

Abstract

Objective
This study aimed to synthesize the evidence from randomized clinical trials in people with nontraumatic degenerative meniscal pathology by comparing physical therapist interventions versus or combined with arthroscopic partial meniscectomy (APM).

Methods
Seven electronic databases were searched. Methodological quality was evaluated using the Physiotherapy Evidence Database scale. Data synthesis was performed with random-effects network meta-analysis, and results were summarized using the standardized mean differences.

Results
From 2103 studies, 10 randomized clinical trials comprising 1411 individuals were included. Ninety percent of the selected randomized clinical trials were classified as good quality according to the Physiotherapy Evidence Database scale. All interventions (physical therapist interventions, APM, and APM plus physical therapist interventions) showed reduced pain and physical impairments at 3-month follow-up. However, when a physical therapist intervention was included, greater reductions in pain at rest (APM vs physical therapist interventions: 0.73 [95% CI = 0.20 to 1.26]; APM vs APM plus physical therapist interventions: 0.59 [95% CI = 0.15 to 1.03]) and greater increases in the strength of knee extensor muscles (APM vs physical therapist interventions: 0.44 [95% CI = 0.07 to 0.80]; APM vs APM plus physical therapist interventions: 0.73 [95% CI = 0.29 to 1.16]) were observed at 3 months. By contrast, no differences were found between treatments beyond 3 months.

Conclusion
Physical therapist interventions based on exercise programs demonstrate superior short-term outcomes in pain reduction and knee extensor strength compared to surgical treatment.

Impact
For nontraumatic degenerative meniscal pathology, conservative treatment utilizing a physical therapist intervention approach should be prioritized as the first choice over surgical treatment. It offers comparable or superior short-term pain reduction and strength improvements, with a lower risk of side effects. In cases where surgery is deemed necessary, including postsurgical, physical therapist interventions are highly recommended to enhance muscle strength and alleviate pain.
Effectiveness of sequential lines of biologic and targeted small-molecule drugs in psoriatic arthritis: a systematic review
Authors: Gollins Charlotte E , Vincent Rosie , Fahy Caoimhe , McHugh Neil , Brooke Mel , Tillett William 
Published: January 2024

Abstract

Objective
To assess current evidence for effectiveness of sequential lines of biologic and targeted small-molecule disease-modifying anti-rheumatic drugs (b/tsDMARDs) when used beyond first-line for psoriatic arthritis (PsA).

Methods
A systematic search of the literature (Medline, Embase, bibliographic searches) was undertaken (October and December 2022) to find studies meeting the criteria of assessing effectiveness of b/tsDMARDs beyond first-line in adults with PsA (PROSPERO CRD42022365298). Risk of bias assessment was undertaken (ROBINS-I/Cochrane RoB2).

Results
Of 2666 abstracts identified and following a full text review of 177 psoriatic disease studies, 12 manuscripts and two abstracts were eligible. Of the 12 manuscripts, 11 were observational and one was a sub-analysis of a RCT (n = 16 081: average age 49.5 years, female 53.3%). Two abstracts (n = 7186) were included. All studies comparing first- and second-line (three studies) found a reduced response in second-line. On average, DAPSA remission (most reported outcome, eight studies) was achieved in 26%, 19% and 10% first-, second- and third-line TNFi, and 22%, 13% and 11% first-, second- and third-line other bDMARDs, respectively. Responses varied to third-line bDMARDs; four studies found comparable second- and third-line responses, five studies found diminishing responses in sequential lines.

Conclusion
Predominantly observational studies, inherently at high risk of bias, indicate bDMARDs can be effective to third-line in PsA, but that response is reduced after first line. There is very limited data for more advanced lines of b/tsDMARD. Prospective studies are required to better understand clinical response to advanced lines of treatment in PsA.
Optimizing chemical-induced premature chromosome condensation assay for rapid estimation of high-radiation doses
Authors: Nakayama Ryo , Anderson Donovan , Goh Valerie Swee Ting , Fujishima Yohei , Yanagidate Kaito , Ariyoshi Kentaro , Kasai Kosuke , Yoshida Mitsuaki A , Blakely William F , Miura Tomisato 
Published: January 2024

Abstract
In the event of exposure to high doses of radiation, prompt dose estimation is crucial for selecting appropriate treatment modalities, such as cytokine therapy or stem cell transplantation. The chemical-induced premature chromosome condensation (PCC) method offers a simple approach for such dose estimation with significant radiation exposure, but its 48-h incubation time poses challenges for early dose assessment. In this study, we optimized the chemical-induced PCC assay for more rapid dose assessment. A sufficient number of PCC and G2/M-PCC cells were obtained after 40 h of culture for irradiated human peripheral blood up to 20 Gy. By adding caffeine (final concentration of 1 mM) at 34 h from the start of culture, G2/M-PCC index increased by 1.4-fold in 10 Gy cultures. There was also no significant difference in the G2/M-PCC ring frequency induced for doses 0 to 15 Gy between our 40-h caffeine-supplemented chemical-induced PCC method and the conventional 48-h PCC assay.
Effect of COVID-19 on sexual function and activities among reproductive-age women in Ibadan, South-West Nigeria
Authors: Abdus-Salam Rukiyat Adeola , Idowu Oluwasegun Caleb , Akinlusi Fatimat Motunrayo , Bello Yusuf , Morhason-Bello Imran Oludare 
Published: January 2024

Abstract

Background
Since the outbreak of COVID-19 disease, the environment, families, individuals, and their ways of living have been affected. Social distancing was one of the strategies for the prevention of SARS-CoV-2 infection. It led to limited social interactions for fear of contracting the infection, which ultimately affected relationships, among which is sexual health.

Aim
To determine the risk of female sexual dysfunction and the effect of the COVID-19 pandemic on sexual function and activities among women of reproductive age in Ibadan, South-West Nigeria.

Methods
This cross-sectional study of 218 reproductive-age women evaluated the sexual function before, during, and after the COVID-19 disease pandemic and lockdown. Pretested semistructured self-administered questionnaires with the Female Sexual Function Index (FSFI) were used for data collection. Information collected included sociodemographic and gynecologic characteristics and COVID-19 experiences, as well as sexual history and function before, during, and after the COVID-19 pandemic lockdown. The level of significance was set at P &lt; .05.

Outcomes
Respondents were aged 20 to 50 years (95%) with a mean ± SD age of 34.82 ± 8.52 years; the majority were married (75.58%); one-fifth (21.9%) tested positive for COVID-19 infection; and participants who tested positive for COVID-19 infections were mostly health care workers.

Results
An absence of sexual activity was reported in 9.18% of participants during lockdown, 7.73% before lockdown, and 4.18% after lockdown. The risk of female sexual dysfunction was prevalent among participants, especially those who tested positive for COVID-19 infection. The prevalence was worse during the pandemic lockdown (53.57%) than before (48.39%) or after (51.61%), and a similar pattern was seen among those who tested negative. There was no statistically significant difference in risk of developing sexual dysfunction during the COVID-19 pandemic between those who tested positive and negative to COVID-19. The arousal and desire domains contributed the highest proportion of low FSFI scores.

Clinical Implications
Nationwide lockdowns, which may be a method of control for pandemics, may result in psychosocial complications such as female sexual dysfunction.

Strength and Limitations
Most respondents had tertiary education and were able to respond to self-administered questionnaires, yet the risk of recall bias remains a concern whereas the pandemic met the world unprepared and baseline FSFI prior the pandemic was not available for participants. There are no local validation studies for the FSFI in Nigeria, which could have aided interpretation of results.

Conclusion
A low FSFI score is prevalent in Ibadan, South-West Nigeria, with a higher incidence reported during the COVID-19 pandemic lockdown.
Comparative Effectiveness of Open Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion
Authors: Jagtiani Pemla , Karabacak Mert , Margetis Konstantinos 
Published: January 2024

Study Design:
Umbrella review of meta-analyses.

Objective:
To compile existing meta-analyses to provide analysis of the multiple postoperative outcomes in a comparison of open-transforaminal lumbar interbody fusions (O-TLIFs) versus minimally invasive transforaminal interbody fusions (MI-TLIFs).

Summary of Background Data:
TLIF is the standard surgical intervention for spinal fusion in degenerative spinal diseases. The comparative effectiveness of MI-TLIFs and O-TLIFs remains controversial.

Methods:
A literature search was conducted in the PubMed, Scopus, and Web of Science databases. Titles and abstracts were initially screened, followed by a full-text review based on the inclusion criteria. Twenty articles were deemed eligible for the umbrella review. Data extraction and quality assessment using A Measurement Tool to Assess Systematic Reviews were performed. Effect sizes of the outcomes of interest from primary studies included in the meta-analyses were repooled. Repooling and stratification of the credibility of the evidence were performed using the R package metaumbrella. The pooled effect sizes were compared and interpreted using equivalent Hedges’ g values.

Results:
When the meta-analyses were pooled, MI-TLIF was found to have a shorter length of stay, less blood loss, and a higher radiation exposure time, with a highly suggestive level of evidence. Data regarding less postoperative drainage, infections, and Oswestry disability index for MI-TLIF were supported by weak evidence. Conversely, data regarding other postoperative outcomes were nonsignificant to draw any conclusions.

Conclusion:
Our umbrella review provides a comprehensive overview of the relevant strengths and weaknesses of each surgical technique. This overview revealed that MI-TLIF had better outcomes in terms of length of stay, blood loss, postoperative drainage, infections, and Oswestry disability index when compared with those of O-TLIF. However, O-TLIF had a better outcome for radiation exposure when compared with MI-TLIF.
Occupational Dust Exposure as a Risk Factor for Developing Lung Function Impairment
Authors: Saers Johannes James , Bryngelsson Ing-Liss , Sundh Josefin , Janson Christer , Andersson Lena 
Published: January 2024

Objective
Dust exposure is high in several industries. We investigated associations of exposure in paper mills, wood pellet plants, and iron foundries with lung function impairment.

Methods
Respirable silica, inhalable paper dust, or inhalable wood dust were collected as personal samples and spirometry was performed. Multiple linear regression analyzed associations with FEV1%pred and FVC%pred.

Results
Wood pellet workers with high exposure to inhalable dust had lower FEV1%pred (95% CI) (−9.4 [−16 to −2.6]) and FVC%pred (−9.8 [−15 to −4.0]) compared with lowest exposure level. Workers at paper mills and foundries had no dose-dependent association but lower FEV1%pred and FVC%pred than in workers at wood pellets plants.

Conclusions
Increased exposure to inhalable wood dust is associated with decreased lung function. Foundry and paper mill workers have generally lower lung function than wood pellet workers. Spirometry should be considered in workers in industries with airborne particulate matter pollution.
Treatment of Complex Desmoid Tumors in Familial Adenomatous Polyposis Syndrome by Intestinal Transplantation
Authors: Canovai Emilio , Butler Andrew , Clark Susan , Latchford Andrew , Sinha Ashish , Sharkey Lisa , Rutter Charlotte , Russell Neil , Upponi Sara , Amin Irum 
Published: January 2024

Background.
Desmoid tumors are fibroblastic lesions which often have an unpredictable and variable clinical course. In the context of familial adenomatous polyposis (FAP), these frequently occur intra-abdominally, especially in the small-bowel mesentery resulting in sepsis, fistulation, and invasion of the abdominal wall and retroperitoneum. In selected cases where other modalities have failed, the most radical option is to perform a total enterectomy and intestinal transplantation (ITx). In this study, we present our center’s experience of ITx for desmoid in patients with FAP.

Methods.
We performed a retrospective review of our prospectively collected database between 2007 and 2022. All patients undergoing ITx for FAP-related desmoid were included.

Results.
Between October 2007 and September 2023, 144 ITx were performed on 130 patients at our center. Of these, 15 patients (9%) were for desmoid associated with FAP (7 modified multivisceral transplants, 6 isolated ITx, and 2 liver-containing grafts). The median follow-up was 57 mo (8–119); 5-y patient survival was 82%, all with functioning grafts without local desmoid recurrence. These patients presented us with several complex surgical issues, such as loss of abdominal domain, retroperitoneal/abdominal wall involvement, ileoanal pouch–related issues, and the need for foregut resection because of adenomatous disease.

Conclusions.
ITx is a viable treatment in selected patients with FAP and extensive desmoid disease. The decision to refer for ITx can be challenging, particularly the timing and sequence of treatment (simultaneous versus sequential exenteration). Delays can result in additional disease burden, such as secondary liver disease or invasion of adjacent structures.
Cross-societal variation in norm enforcement systems
Authors: Molho Catherine , De Petrillo Francesca , Garfield Zachary H. , Slewe Sam 
Published: January 2024

Across human societies, people are sometimes willing to punish norm violators. Such punishment can take the form of revenge from victims, seemingly altruistic intervention from third parties, or legitimized sanctioning from institutional representatives. Although prior work has documented cross-cultural regularities in norm enforcement, substantial variation exists in the prevalence and forms of punishment across societies. Such cross-societal variation may arise from universal psychological mechanisms responding to different socio-ecological conditions, or from cultural evolutionary processes, resulting in different norm enforcement systems. To date, empirical evidence from comparative studies across diverse societies has remained disconnected, owing to a lack of interdisciplinary integration and a prevalent tendency of empirical studies to focus on different underpinnings of variation in norm enforcement. To provide a more complete view of the shared and unique aspects of punishment across societies, we review prior research in anthropology, economics and psychology, and take a first step towards integrating the plethora of socio-ecological and cultural factors proposed to explain cross-societal variation in norm enforcement. We conclude by discussing how future cross-societal research can use diverse methodologies to illuminate key questions on the domain-specificity of punishment, the diversity of tactics supporting social norms, and their role in processes of norm change.
This article is part of the theme issue ‘Social norm change: drivers and consequences’.
The expressive function of public policy: renewable energy mandates signal social norms
Authors: Syropoulos Stylianos , Sparkman Gregg , Constantino Sara M. 
Published: January 2024

Addressing collective action problems requires individuals to engage in coordinated and cooperative behaviours. Existing research suggests that individuals' propensity to work together depends in part on their belief that others support the cause in question. People form their expectations about prevalent beliefs and behaviours from many sources. To date, most of the literature has focussed on how social norm perceptions are inferred from peers or summary statistics. We explore an understudied source of norm information: the passage of policies by democratically elected institutions. Institutional signals, such as the setting of defaults, national laws or policies, can act as coordination devices, signalling or prescribing social norms to large audiences. However, their expressive function is likely to depend on whether the institution is seen as accountable to the public. In two highly powered, pre-registered experiments (N= 11 636), we examine the role of policy signals as a source of social norm information. In Study 1, Americans randomly assigned to learn that their state passed a 100% renewable energy mandate believe that a greater percentage of their state's residents support such a mandate. In Study 2, we replicate this effect for national policy and show that the influence is moderated by information about whether the government represents the will of the people.This article is part of the theme issue ‘Social norm change: drivers and consequences’.
miR-100andmiR-125bContribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells
Authors: Nelson Hannah M. , Qu Shimian , Huang Liyu , Shameer Muhammad , Corn Kevin C. , Chapman Sydney N. , Luthcke Nicole L. , Schuster Sara A. , Turnbull Lauren A. , Guy Lucas L. , Liu Xiao , Vickers Kasey C. , Liu Qi , Franklin Jeffrey L. , Weaver Alissa M. , Rafat Marjan , Coffey Robert J. , Patton James G. 
Published: January 2024

AbstractExtracellular communication via the transfer of vesicles and nanoparticles is now recognized to play an important role in tumor microenvironment interactions. Cancer cells upregulate and secrete abundant levels ofmiR-100andmiR-125bthat can alter gene expression by both cell- and non-cell-autonomous mechanisms. We previously showed that these miRNAs activate Wnt signaling in colorectal cancer (CRC) through noncanonical pairing with 5 negative regulators of Wnt signaling. To identify additional targets ofmiR-100andmiR-125b, we used bioinformatic approaches comparing multiple CRC cell lines, including knockout lines lacking one or both of these miRNAs. From an initial list of 96 potential mRNA targets, we tested 15 targets with 8 showing significant downregulation in the presence ofmiR-100andmiR-125b. Among these, Cingulin (CGN) and Protein tyrosine phosphatase receptor type-R (PTPRR) are downregulated in multiple cancers, consistent with regulation by increased levels ofmiR-100andmiR-125b.We also show that increased cellular levels ofmiR-100andmiR-125benhance 3D growth and invasiveness in CRC and glioblastoma cell lines. Lastly, we demonstrate that extracellular transfer ofmiR-100andmiR-125bcan silence both reporter and endogenous mRNA targets in recipient cells and also increase the invasiveness of recipient spheroid colonies when grown under 3D conditions in type I collagen.
Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma
Authors: Bischoff Megan E. , Shamsaei Behrouz , Yang Juechen , Secic Dina , Vemuri Bhargav , Reisz Julie A. , D’Alessandro Angelo , Bartolacci Caterina , Adamczak Rafal , Schmidt Lucas , Wang Jiang , Martines Amelia , Biesiada Jacek , Vest Katherine E. , Scaglioni Pier P. , Plas David R. , Patra Krushna C. , Gulati Shuchi , Figueroa Julio A. Landero , Meller Jarek , Cunningham J. Tom , Czyzyk-Krzeska Maria F. 
Published: January 2024

SUMMARYCopper (Cu) is an essential trace element required for mitochondrial respiration. Late-stage clear cell renal cell carcinoma (ccRCC) accumulates Cu and allocates it to mitochondrial cytochrome c oxidase. We show that Cu drives coordinated metabolic remodeling of bioenergy, biosynthesis and redox homeostasis, promoting tumor growth and progression of ccRCC. Specifically, Cu induces TCA cycle-dependent oxidation of glucose and its utilization for glutathione biosynthesis to protect against H2O2generated during mitochondrial respiration, therefore coordinating bioenergy production with redox protection. scRNA-seq determined that ccRCC progression involves increased expression of subunits of respiratory complexes, genes in glutathione and Cu metabolism, and NRF2 targets, alongside a decrease in HIF activity, a hallmark of ccRCC. Spatial transcriptomics identified that proliferating cancer cells are embedded in clusters of cells with oxidative metabolism supporting effects of metabolic states on ccRCC progression. Our work establishes novel vulnerabilities with potential for therapeutic interventions in ccRCC.Accumulation of copper is associated with progression and relapse of ccRCC and drives tumor growth.Cu accumulation and allocation to cytochrome c oxidase (CuCOX) remodels metabolism coupling energy production and nucleotide biosynthesis with maintenance of redox homeostasis.Cu induces oxidative phosphorylation via alterations in the mitochondrial proteome and lipidome necessary for the formation of the respiratory supercomplexes.Cu stimulates glutathione biosynthesis and glutathione derived specifically from glucose is necessary for survival of CuHicells. Biosynthesis of glucose-derived glutathione requires activity of glutamyl pyruvate transaminase 2, entry of glucose-derived pyruvate to mitochondria via alanine, and the glutamate exporter, SLC25A22. Glutathione derived from glucose maintains redox homeostasis in Cu-treated cells, reducing Cu-H2O2Fenton-like reaction mediated cell death.Progression of human ccRCC is associated with gene expression signature characterized by induction of ETC/OxPhos/GSH/Cu-related genes and decrease in HIF/glycolytic genes in subpopulations of cancer cells. Enhanced, concordant expression of genes related to ETC/OxPhos, GSH, and Cu characterizes metabolically active subpopulations of ccRCC cells in regions adjacent to proliferative subpopulations of ccRCC cells, implicating oxidative metabolism in supporting tumor growth.