bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring Sodium Carboxymethylcellulose Binders for High‐Voltage LiCoO2 via Thermal Pulse Sintering
Authors: Chen Shiming , Zhu Hengyao , Li Jiangxiao , Yin Zu‐Wei , Chen Taowen , Yao Xiangming , Zhao Wenguang , Xue Haoyu , Jiang Xin , Li Yongsheng , Ren Hengyu , Chen Jun , Li Jun‐Tao , Yang Luyi , Pan Feng 
Published: February 2025

AbstractPolyvinylidene fluoride (PVDF), as the commercial cathode binder for lithium‐ion batteries, presents several practical challenges, including insufficient conductivity, weak adhesion to active materials, and the use of toxic N‐methylpyrrolidone for slurry preparation. However, while most water‐soluble binders can address the aforementioned issues, they fail to meet the requirements of high‐voltage cathodes. In this work, we innovatively employed a thermal pulse sintering strategy to modify carboxymethyl cellulose sodium (CMC), enabling their application in 4.6 V LiCoO2 (93 % capacity retention after 200 cycles). This strategy facilitates the decomposition of electrochemically active carboxyl groups, leading to ring opening reactions that generate numerous ether linkages (‐C−O−C‐) without introducing undesirable side effects on LiCoO2. The resulting components form additional charge carrier (i.e., Li+ and e−) pathways on the cathode surface. Additionally, the heating process also promotes uniform coating of the binder on the surface of LiCoO2, creating a protective layer that inhibits interfacial side reactions. Through proposing a scalable and economic manufacturing technology of multifunctional binder, this work enlightens the avenues for practical high‐energy‐density batteries.
Functional Polyimide/CsxWO3 Composite Aerogel With Photothermal Conversion Ability and Thermal Insulation Performance
Authors: Xu Jing , Liu Jingxiao , Shi Fei , Xiao Jianbin , Pei Wen , Yu Chen 
Published: February 2025

ABSTRACTWith the development of industrialization, there is an urgent need for energy‐saving materials with lightweight, thermal insulation and fire resistance. Here, we prepared a novel polyimide/CsxWO3 (PIC) composite aerogel with excellent mechanical properties, good thermal stability, thermal insulation, and outstanding photothermal conversion performance using CsxWO3 as a light absorber by directional freezing and imidization. Unlike conventional polyimide aerogels, the introduction of CsxWO3 NPs enhanced the aerogel network and effectively mitigated shrinkage and deformation during freeze‐drying. This synergistic effect endows the PIC aerogel with excellent mechanical strength (withstanding 500 cycles of fatigue tests), high thermal stability (maximum decomposition temperature close to 600°C), and strong hydrophobicity. Furthermore, the enhanced photothermal conversion efficiency, driven by CsxWO3 NPs, ensures efficient photon absorption. A simulation experiment on the thermal insulation performance demonstrates that employing a PIC film as the outer enclosure of a simulated insulation box can markedly enhance the thermal insulation effect, leading to a reduction of 12.2°C in the internal temperature. The novel integration of photothermal and thermal insulation properties in this composite aerogel represents a clear advancement over existing materials, making it highly promising for energy‐efficient thermal insulation technologies.
Improving vertical detail in simulated temperature and humidity data using machine learning
Authors: da Silva Rodrigues Joana D. , Morcrette Cyril J. 
Published: February 2025

AbstractAtmospheric models used for weather forecasting and climate predictions discretise the atmosphere onto a vertical grid. There are however atmospheric phenomena that occur on scales smaller than the thickness of those model layers. The formation of low‐level clouds due to temperature inversions is an example. This leads to atmospheric models underestimating, or even missing, these clouds and their radiative effects. Using radiosonde observations as training data, a machine learning model is used to improve the vertical detail of modelled profiles of temperature and specific humidity. In addition, a physics‐informed machine learning model is developed and compared to the traditional approach; showing improvements in the cloud fraction profiles calculated from its predictions. The vertically enhanced profiles also improve the representation of layers of convective inhibition and anomalous refractivity gradients. This work facilitates targeted improvements to the representation of certain atmospheric processes without the burden of increased memory and computational cost from increasing vertical resolution throughout the whole model.
Demonstrating the Effectiveness of an Alternative to Triton X‐100 for Detergent‐Mediated Viral Inactivation in Biomanufacturing
Authors: Banerjee Kakolie , Antonello Alice , Johnson Sandra , Licht Anja , Rapp Almut , Miller Corinne 
Published: February 2025

ABSTRACTDetergent‐mediated viral inactivation is an important process step for ensuring viral safety of parenteral biotherapeutics, including plasma proteins and monoclonal antibodies (mAb). The conventional Triton X‐100 detergent has ecological toxicity concerns and REACH classification that mandate replacement in the biopharmaceutical industry. Criteria for a replacement detergent include viral inactivation efficacy, acceptable safety and biodegradation profile, process removal, and quality suitable for parenteral drug product manufacturing. A non‐ionic, C11‐15 secondary alcohol ethoxylate, Deviron 13‐S9 detergent, has been demonstrated to meet the necessary requirements for detergent performance. Benchmarking studies with Triton X‐100 detergent demonstrate comparable performance with a panel of enveloped viruses in multiple matrices, including human IgG, clarified cell culture harvest, and fractionated plasma. Deviron 13‐S9 detergent demonstrated viral inactivation efficiency comparable to or better than Triton X‐100 detergent, achieving > 5 log reduction values. Critical micelle concentration was determined across different temperatures and media. Deviron 13‐S9 detergent was demonstrated to be readily biodegradable according to OECD 301B guidelines. The absence of detergent binding to typical chromatography resins used in downstream purification was confirmed. The process removal of Deviron 13‐S9 detergent from a protein‐containing matrix was demonstrated using a protein A resin. These findings support Deviron 13‐S9 detergent as a viable alternative to Triton X‐100 detergent, ensuring robust viral inactivation, environmental compatibility, and alignment with regulatory requirements.
The use of molecular and cell biology scientific news to facilitate learning and scientific thinking
Authors: Giojalas Laura C. , Romano Leticia García , Lingua Giuliana , Martín Rocío B. 
Published: February 2025

AbstractMolecular Cell Biology (MCB) should be taught according to the scientific practices, avoiding cumulative and memory knowledge construction, but favoring scientific thinking. A way to achieve this goal is to apply activities involving scientific news, which construct knowledge through significant learning and the development of critical thinking. The study aimed to evaluate the implementation of learning activities involving scientific news in the MCB course at the undergraduate level. The perspective of design‐based research was applied, whereas the cognitive and interpersonal aspects were evaluated by means of the professors' narration, class registration, questionnaires answered by the students, and the evaluation of the activities carried out by the students. Results showed that the activity involving scientific news reinforces the construction and integration of new knowledge with that previously acquired and consolidates the acquisition of scientific thinking. Even though the completion of the activity involved a complex process, according to the professor and students' opinion, the students observed positive aspects such as the application of biological and scientific language and the motivation to search for related information. Regarding the cooperative learning strategy, students perceived that it is a methodology that facilitates their learning. In summary, incorporating scientific news into MCB courses will enhance professors' effectiveness in achieving didactic goals while also fostering scientific thinking in students, equipping them for future roles as biologists and professors in biological sciences.
Pre‐stimulus activities affect subsequent visual processing: Empirical evidence and potential neural mechanisms
Authors: Dehaghani Narjes Soltani , Zarei Mojtaba 
Published: February 2025

AbstractPurposeHumans obtain most of their information from visual stimuli. The perception of these stimuli may be modulated by the ongoing pre‐stimulus brain activities. Depending on the task design, the processing of different cognitive functions such as spatial attention, feature‐based attention, temporal attention, arousal, and mental imagery may start prior to the stimulus onset.MethodThis process is typically accompanied by changes in pre‐stimulus oscillatory activities including power, phase, or connectivity in different frequency bands. To explain the effect of these changes, several mechanisms have been proposed. In this article, we review these changes and the potential mechanisms in the context of the pre‐stimulus enabled cognitive functions. We provide evidence both in favor of and against the most documented mechanisms and conclude that no single mechanism can solely delineate the effects of pre‐stimulus brain activities on later processing. Instead, multiple mechanisms may work in tandem to guide pre‐stimulus brain activities.FindingAdditionally, our findings indicate that in many studies a combination of these cognitive functions begins prior to stimulus onset.ConclusionThus, dissociating these cognitive functions is challenging based on the current literature, and the need for precise task designs in later studies to differentiate between them is crucial.
Clients' Reasons for Dropping Out of Therapy: A Qualitative Study
Authors: Homan Jesse B. , Talbott Maria M. , Holliday Mic 
Published: February 2025

ABSTRACTAimThere has been limited research on therapy attrition from the perspective of clients who terminate. This qualitative study addresses the question, why do clients choose to terminate therapy prematurely?MethodTwelve participants who had chosen to end in‐person individual therapy were interviewed.FindingsThe most common reason for terminating was experiencing invalidation from the therapist, including not feeling heard, feeling dismissed and judged and not feeling valued. Another type of invalidation experienced was therapists' microaggressions on client identities of race, culture and sexual orientation. Inadequate problem‐solving in therapy, through oversimplification of problem‐solving or not receiving guidance for change, was another common reason for dropout.DiscussionUnderstanding the perspectives of clients who have been dissatisfied with therapy is useful for identifying therapist behaviours that can cause ruptures. Clinicians can learn from clients' negative experiences in therapy in order to improve clinical practice.
Pharyngoplasty With Suture of Mucosal Flap Complementary Coverage for Treating Pharyngeal Stenosis
Authors: Lu Zhiyan , Wang Yimiao , Li Dan , Chen Siyi , Ma Shuaichi , He Peijie 
Published: February 2025

ABSTRACTExploring a new method of pharyngoplasty surgery, which uses CO2 laser to dislocate the mucosa and then covers the wound with mucosal flap complementary sutures, successfully preventing postoperative pharyngeal stenosis.
Current‐Potential‐Time Response of the Second‐Order Co‐Reactant Mechanism: An Analytical Theoretical Approach
Authors: Laborda Eduardo , López‐Asanza Javier , Moreno‐Molina Judit , Gonzalez Joaquín , Molina Angela 
Published: February 2025

AbstractAn analytical approach is presented for the voltammetric and chronoamperometric study of a second‐order cyclic‐type mechanism where two species are ‘activated’ electrochemically and subsequently react in solution, as observed in co‐reactant electrochemiluminescence mechanisms. Closed‐form expressions are derived for the current‐potential‐time response and for the surface species concentrations as a function of the chemical rate constant, the concentration ratio of the initial species, and their formal potentials. Their effects on the voltammetric signal are analyzed, pointing out a wave‐splitting behaviour for fast kinetics, which is tied to the rates of formation and consumption of the ‘activated’ co‐reactant.
Design of Rigid Compounds to Enhance Selectivity for Carbonic Anhydrase IX
Authors: Vaškevičius Aivaras , Trumpickaitė Gabrielė , Parafjanovič Edvin , Manakova Elena , Mickevičiūtė Aurelija , Gedgaudas Marius , Kojis Tautvydas , Paketurytė‐Latvė Vaida , Smirnov Alexey , Baranauskiene Lina , Gražulis Saulius , Zubrienė Asta , Dudutienė Virginija , Matulis Daumantas 
Published: February 2025

AbstractHigh affinity and selectivity for intended targets is an important goal of small molecule design in drug discovery, yet balancing molecular flexibility and rigidity remains a challenge. While flexible compounds can increase target affinity, they often result in non‐specific interactions and reduced selectivity. In contrast, rigid compounds may recognize their target more precisely and have lower off‐target effects. In this study, we incorporated a 1,1‐dioxido‐1,4‐thiazine ring into fluorinated benzenesulfonamide derivatives with bulky meta‐substituents to enhance selectivity for human carbonic anhydrase IX (CAIX), an important cancer‐associated target. Due to the structural similarities of CAIX with other carbonic anhydrase isozymes, selective inhibition remains a significant challenge. A series of 3,4‐substituted trifluorobenzenesulfonamides containing oxidized thiazine rings were synthesized using a novel synthetic pathway. Although the potency against CAIX was modestly reduced compared to more flexible analogs, selectivity increased significantly, with lead compounds 7 d and 7 e exhibiting over 1000‐fold selectivity for CAIX over most other isozymes. X‐ray crystallography revealed the structural basis for this selectivity, confirming the advantageous positioning of rigidified compounds within some CA isozyme active sites. These findings highlight the potential of molecular rigidity in the design of highly selective inhibitors for therapeutic applications.
Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma
Authors: Takayesu Jamie S. K. , Parvathaneni Upendra , Laramore George E. , Panjwani Neil , Sillings Jennifer , Futran Neal D. , Humphreys Ian M. , Jafari Aria , Abuzeid Waleed M. , Barber Brittany , Marchiano Emily , Lee Sylvia M. , Thompson John A. , Hall Evan , Bhatia Shailender , Rodriguez Cristina P. , Liao Jay J. 
Published: February 2025

ABSTRACTBackgroundHead and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.AimsWe performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan–Meier estimates were used for survival analyses.Methods and ResultsEight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow‐up was 15 months (range: 3–68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan–Meier 1‐year results were as follows: local control 88%, distant metastasis‐free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.ConclusionSurgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi‐institutional work is needed to study this rare malignancy.
Integrated Measurement of Accountability in a Circular Economy and Its Main Determinants in Waste Companies
Authors: Kuba‐Khoury Víctor , Scarpellini Sabina , Aranda‐Usón Alfonso 
Published: February 2025

ABSTRACTThe study examines circular reporting practices and their determinants that lead to different levels of circular accountability, such as the quality of being transparent and exhaustive, to give an account of the companies' circular economy‐related activities. A dual methodological approach is adopted, combining statistical‐descriptive and qualitative methods to analyze data from 145 Spanish waste‐sector companies from 2018 to 2023. Findings highlight that most waste companies disseminate sustainability, general circular economy principles, and waste recovery information. The main results significantly contribute to accounting practitioners' circular reporting, pointing out that a specific disclosure of circular impacts and collaborative models in the value chain is needed to improve higher levels of disclosure in the waste sector. Companies in the sector tend to achieve a higher level of circular accountability as they grow larger or older. Given the application of the European Union sustainability disclosure rules, the study contributes to the research debate on circular accounting and reporting. If policymakers aim to increase circular reporting, specific monitoring should be targeted to waste sector disclosure practices, particularly inter‐company and collaborative items for circular waste.
Real‐Time Implementation of Double‐Tied Cross‐Link and Series–Parallel Reconfiguration in a Solar Tree Integrated With Adaptive Voltage Interval Search Maximum Power Tracking Algorithm
Authors: A Chandra Sekhar , Ramesh Tejavathu , Isradani Tangirala 
Published: February 2025

ABSTRACTThis paper presents a dual method for enhancing power output using reconfigurable solar tree through array reconfiguration and rapid global maximum power point tracking (GMPPT). An in‐depth literature review on maximum power point tracking (MPPT) reveals that existing algorithms—encompassing conventional, meta‐heuristic, and selective logical algorithms—primarily utilize voltage and/or current search for peak power tracking, often at the expense of tracking time. This work introduces a new method for maximizing power extraction by addressing two key areas: improving power through photovoltaic (PV) array reconfiguration double‐tied cross‐link (DTCL) and utilizing a novel adaptive voltage interval search (AVIS)–based MPPT technique. The effectiveness of the DTCL configuration compared with the conventional series–parallel (SP) configuration is verified through MATLAB/simulation studies. Additionally, the proposed array reconfiguration with AVIS MPPT is validated on an experimental prototype using a low‐cost digital signal processor, TMS320F289D, under various conditions including partial shading and uniform irradiance. The results, which are presented and analyzed, stands on significant power savings along rapid reaching of operating point with proposed AVIS Algorithm.
Stress‐Relaxed Driver System Using Power‐Delay Efficient Level Shifters for Compute‐in‐Memory Based on the Floating Gate Devices
Authors: Yu Zhiguo , Dong Yating , Qiao Yang , Lin Zhengyuan , Gu Xuyuan , Gu Xiaofeng 
Published: February 2025

ABSTRACTIn this paper, a stress‐relaxed driver system applied to compute‐in‐memory (CIM) is proposed for programming, reading and erasing of the CIM chip. The driver system utilizes a hierarchical regulation method to achieve accurate row and column selectivity, reducing the area overhead of the peripheral driver system for the CIM array. In order to suppress the voltage fluctuation of the power supply and ground caused by direct path currents, power‐delay efficient positive and negative voltage level shifters are proposed. The proposed level shifters allows transistors used in the driver system to switch voltages at the safe operating limit. The driver system based on 1024 2048 floating gate devices is implemented using a 65‐nm CMOS process. The driver system converts a 1.8‐V voltage‐domain input signal to a high‐voltage‐domain output voltage, which meets the requirements of operating transmissions from −10 to 9 V. The simulation results show that the maximum voltage stress in the driver system is less than 12 V, achieving a reduction of 21.9% compared to the previous study. Simultaneous switching of 256 word‐lines can be achieved across the temperature range of −40°C to 125°C with a 2‐pF capacitive load. The driver system can support the switching of the program, erase, and read modes. In the read mode, the delay remains less than 13 ns for the gate voltage of floating gate devices ranging from 3 to 7 V. We conducted the comparative analysis and simulations of the proposed level shifters to elucidate pertinent design trade‐offs. The comparison results show that the proposed level shifters exhibit significant advantages in peak current and power consumption compared with the topologies of various level shifters and have the lowest power‐delay product.
Design, Synthesis, Docking Studies, and Investigation of Dual EGFR/VEGFR‐2 Inhibitory Potentials of New Pyrazole and Pyrazolopyridine Derivatives
Authors: Alhamaky Shimaa M. , Khalil Nadia A. , Bass Amr K. A. , Osama Nada , Hassan Marwa S. A. 
Published: February 2025

ABSTRACTThe anticancer potential of certain newly synthesized pyrazole and pyrazolopyridine derivatives has been estimated. NCI 60 cancer cells cytotoxic screening pointed out compounds 3e and 3f as the highest cytotoxic agents with % mean growth inhibition of 67.69% and 87.34%, respectively. The five dose outcomes outlined 3f as the most potent cytotoxic agent with promising MG‐MID GI50 = 3.3 µM when compared to erlotinib (MG‐MID GI50 = 7.68 µM). In the in vitro assays, compounds 3d, 3e, 3f, and 4a demonstrated dual inhibitory potential on EGFRWT and VEGFR‐2 with IC50 range of 0.066−0.184 µM and 0.102−0.418 µM, respectively. The best dual EGFR/VEGRF‐2 inhibitory effect was shown by the compound 3f. Moreover, the latter compound stopped the cell cycle at the G1/S phase. Also, it greatly boosted total apoptosis, including early and late apoptosis, by 54.5‐ and 84.7‐fold, respectively, which supposes HCT‐116 cell death via inducing apoptosis. This was confirmed by the elevation of the BAX and caspase‐3 levels, and the decreased BCL‐2 level. Moreover, the safety of the most active compound 3f was assessed and the results showed promising selectivity of compound 3f toward HCT‐116 over FHC (selectivity index [SI]: 20.84) when compared to erlotinib (SI: 3.42). Finally, compound 3f demonstrated efficient binding to both EGFR and VEGFR‐2 enzymes, which could explain the sufficient inhibition level of each enzyme.
Experimentation of Heterocycles (2013‐22) as Potent Pharmacophores in Drug Design of Multiple Sclerosis
Authors: Dorababu Atukuri 
Published: February 2025

ABSTRACTMultiple sclerosis (MS) is a demyelinating disease in which the insulating cover (myelin sheath) of the brain and spinal cord is damaged. Demyelination results in a decreased signal transmission in the nervous system. Symptoms include double vision, muscle weakness, and difficulty with coordination. Genetic and viral infections have been proposed as plausible factors responsible for MS. Although there is no cure for MS, treatment prevents future attacks. At present, chemotherapy and monoclonal antibodies are the available treatments for MS. Heterocyclic compounds are currently being tested clinically for their efficacy. Some heterocyclic scaffolds have been found to be promising for the treatment of MS. In view of this, research has been conducted towards the design and discovery of chemical agents for MS. Hence, the literature relevant to drug design for MS in the last decade has been collated and described comprehensively so that it would be helpful for efficient drug design for MS in the future. Additionally, through the structure–activity relationship, the importance of crucial structural features was emphasized. The classification was primarily based on the type of heterocycle.