bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memperkuat Integrasi Nasional Di Era Digital : Penguatan Resolusi Konflik Di Era Digital Sebagai Perwujudan Warga Negara Yang Baik
Authors: HIdayah Yayuk , Nufikha Ulfah  , Meiwatizal Trihastuti  
Published: November 2023

Penelitian ini membahas mengenai bagaimana memperkuat integrasi nasional di era digital melalui penguatan resolusi konflik di era digital sebagai perwujudan warga negara yang baik. Tujuan dari penelitian ini adalah untuk menganalisis konsep resolusi konflik dan bagaimana penerapannya dalam konteks perwujudan warga negara yang baik di era digital . Metode penelitian yang dgunakan adalah pendekatan deskriptif dengan menggunakan data sekunder dari literatur yang relevan seperti buku, jurnal akademik, dan sumber-sumber online. Data tersebut kemudian dianalisis melalui pendekatan kualitatif untuk menghasilkan temuan-temuan yang relevan. Hasil penelitian menunjukkan bahwa konsep resolusi konflik dalam konteks perwujudan warga negara yang baik di era digital ialah dengan memperkenalkan peserta didik pada metode penyelesaian konflik yang berbasis dialog, partisipasi aktif, dan pemecahan masalah yang kreatif. Selain itu, Penerapan konsep resolusi konflik dalam pembelajaran PKn dapat meningkatkan kesadaran peserta didik tentang pentingnya menghargai perbedaan dan mempromosikan perdamaian serta keadilan sosial. Teknologi digital seperti media sosial dan platform online dapat digunakan sebagai alat bantu untuk memfasilitasi diskusi dan kolaborasi antar peserta didik. Namun, penggunaan teknologi digital juga memiliki risiko seperti penyebaran informasi yang tidak valid dan peningkatan polarisasi dan kebencian di media sosial. Penelitian ini memberikan pemahaman tentang bagaimana konsep resolusi konflik dapat diterapkan dalam pembelajaran PKn di era digital dan memberikan implikasi untuk pengembangan kurikulum PKn yang lebih adaptif dengan perkembangan teknologi digital.
IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy
Authors: Rambo Ian M. , Kronfel Christina M. , Rivers Adam R. , Swientoniewski Lauren T. , McBride Jane K. , Cheng Hsiaopo , Simon Reyna J. , Ryan Robert , Tilles Stephen A. , Nesbit Jacqueline B. , Kulis Michael D. , Hurlburt Barry K. , Maleki Soheila J. 
Published: November 2023

BackgroundOral immunotherapy (OIT) with peanut (Arachis hypogaea) allergen powder-dnfp (PTAH; Aimmune Therapeutics) is an FDA-approved treatment to desensitize peanut allergic participants.ObjectiveHere we assessed shifts in IgE and IgG4 binding to peanut allergens and their epitopes recognized by United States (US) peanut allergic participants (n = 20) enrolled in phase 3 PTAH OIT clinical trials.MethodsPre- and post- trial participant sera were collected approximately 12 months apart and tested for IgE binding to intact peanut proteins via ImmunoCAP ISAC immunoassays. IgE and IgG4 linear epitopes were identified based on binding to synthetic overlapping 15-mer linear peptides of 10 peanut allergens (Ara h 1-11) synthesized on microarray slides.ResultsStatistically significant decreases in IgE binding were identified for intact Ara h 2, 3, and 6, and known and newly identified IgE epitopes were shown to exhibit shifts towards IgG4 binding post-OIT, with most linear peptides having increased IgG4 binding after treatment with PTAH. While PTAH does not seem to alter the actual peptide binding patterns significantly after one year of treatment, the IgE and IgG4 binding ratios and intensity are altered.ConclusionAt a population level, the linear IgE and IgG4 epitopes of 10 peanut allergens overlap and that increase in IgG4 with OIT results in displacement of IgE binding to both conformational and linear epitopes. Furthermore, it appears as though the increase in IgG4 is more important to achieve desensitization at the 12-month timepoint than the decrease in IgE. This type of knowledge can be useful in the identification of IgE and IgG4-binding allergen and peptide biomarkers that may indicate desensitization or sustained unresponsiveness of allergic individuals to peanut.
The obesity paradox in intracerebral hemorrhage: a systematic review and meta-analysis
Authors: Wang Zexu , Wang Jie , Wang Jiayan , Liao Yinghua , Hu Xin , Wang Manni 
Published: November 2023

BackgroundIntracerebral hemorrhage (ICH) has a mortality rate which can reach 30–40%. Compared with other diseases, obesity is often associated with lower mortality; this is referred to as the ‘obesity paradox’. Herein, we aimed to summarize the studies of the relations between obesity and mortality after ICH.MethodFor this systematic review and meta-analysis (PROSPERO registry CRD42023426835), we conducted searches for relevant articles in both PubMed and Embase. Non-English language literature, irrelevant literature, and non-human trials were excluded. All included publications were then qualitatively described and summarized. Articles for which quantitative analyses were possible were evaluated using Cochrane’s Review Manager.ResultsTen studies were included. Qualitative analysis revealed that each of the 10 studies showed varying degrees of a protective effect of obesity, which was statistically significant in 8 of them. Six studies were included in the quantitative meta-analysis, which showed that obesity was significantly associated with lower short-term (0.69 [0.67, 0.73], p&lt;0.00001) and long-term (0.62 [0.53, 0.73], p&lt;0.00001) mortality. (Data identified as (OR [95%CI], p)).ConclusionObesity is likely associated with lower post-ICH mortality, reflecting the obesity paradox in this disease. These findings support the need for large-scale trials using standardized obesity classification methods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023426835, identifier CRD42023426835.
Prognostic algorithms for post-discharge readmission and mortality among mother-infant dyads: an observational study protocol
Authors: Wiens Matthew O. , Trawin Jessica , Pillay Yashodani , Nguyen Vuong , Komugisha Clare , Kenya-Mugisha Nathan , Namala Angella , Bebell Lisa M. , Ansermino J. Mark , Kissoon Niranjan , Payne Beth A. , Vidler Marianne , Christoffersen-Deb Astrid , Lavoie Pascal M. , Ngonzi Joseph 
Published: November 2023

IntroductionIn low-income country settings, the first six weeks after birth remain a critical period of vulnerability for both mother and newborn. Despite recommendations for routine follow-up after delivery and facility discharge, few mothers and newborns receive guideline recommended care during this period. Prediction modelling of post-delivery outcomes has the potential to improve outcomes for both mother and newborn by identifying high-risk dyads, improving risk communication, and informing a patient-centered approach to postnatal care interventions. This study aims to derive post-discharge risk prediction algorithms that identify mother-newborn dyads who are at risk of re-admission or death in the first six weeks after delivery at a health facility.MethodsThis prospective observational study will enroll 7,000 mother-newborn dyads from two regional referral hospitals in southwestern and eastern Uganda. Women and adolescent girls aged 12 and above delivering singletons and twins at the study hospitals will be eligible to participate. Candidate predictor variables will be collected prospectively by research nurses. Outcomes will be captured six weeks following delivery through a follow-up phone call, or an in-person visit if not reachable by phone. Two separate sets of prediction models will be built, one set of models for newborn outcomes and one set for maternal outcomes. Derivation of models will be based on optimization of the area under the receiver operator curve (AUROC) and specificity using an elastic net regression modelling approach. Internal validation will be conducted using 10-fold cross-validation. Our focus will be on the development of parsimonious models (5–10 predictor variables) with high sensitivity (&gt;80%). AUROC, sensitivity, and specificity will be reported for each model, along with positive and negative predictive values.DiscussionThe current recommendations for routine postnatal care are largely absent of benefit to most mothers and newborns due to poor adherence. Data-driven improvements to postnatal care can facilitate a more patient-centered approach to such care. Increasing digitization of facility care across low-income settings can further facilitate the integration of prediction algorithms as decision support tools for routine care, leading to improved quality and efficiency. Such strategies are urgently required to improve newborn and maternal postnatal outcomes.
Clinical trial registrationhttps://clinicaltrials.gov/, identifier (NCT05730387).
Integration of transcriptomic, proteomic, and metabolomic data to identify lncRNA rPvt1 associations in lipopolysaccharide-treated H9C2 cardiomyocytes
Authors: Zhang Tie-Ning , Wen Ri , Yang Yu-Hang , Yang Ni , Liu Chun-Feng 
Published: November 2023

Background: Recent evidence has shown that the long non-coding RNA (lncRNA) rPvt1 is elevated in septic myocardial tissues and that its knockdown attenuates sepsis-induced myocardial injury. However, the mechanism underlying the role of rPvt1 in septic myocardial dysfunction has not been elucidated.Methods: In this study, we performed transcriptomic, proteomic, and metabolomic assays and conducted an integrated multi-omics analysis to explore the association between rPvt1 and lipopolysaccharide (Lipopolysaccharide)-induced H9C2 cardiomyocyte injury. LncRNA rPvt1 silencing was achieved using a lentiviral transduction system.Results: Compared to those with the negative control, rPvt1 knockdown led to large changes in the transcriptome, proteome, and metabolome. Specifically, 2,385 differentially expressed genes (DEGs), 272 differentially abundant proteins and 75 differentially expressed metabolites (DEMs) were identified through each omics analysis, respectively. Gene Ontology functional annotation, Kyoto Encyclopedia of Genes and Genomes, Nr, eukaryotic orthologous groups, and Clusters of Orthologous Groups of Proteins pathway analyses were performed on these differentially expressed/abundant factors. The results suggested that mitochondrial energy metabolism might be closely related to the mechanism through which Pvt1 functions.Conclusion: These genes, proteins, metabolites, and their related dysregulated pathways could thus be promising targets for studies investigating the rPvt1-regluatory mechanisms involved in septic myocardial dysfunction, which is important for formulating novel strategies for the prevention, diagnosis and treatment of septic myocardial injury.
Insulin infusion sets associated with adverse events: strategies for improved diabetes education
Authors: Neves Ana Lucia Domingues , Martins Luiz Eduardo Galvão , Gabbay Mônica Andrade Lima , Pascali Paula , de Oliveira Tiago , Martinazzo Aldo , Dib Sérgio Atala , Casarini Dulce Elena , Aredes Sebastião Vagner , Tenorio Fernanda Silva , Cunha Tatiana Sousa 
Published: November 2023

IntroductionInsulin Infusion Sets (IIS) play a crucial role in ensuring the safe delivery of insulin through a Continuous Subcutaneous Insulin Infusion (CSII) for individuals with Type 1 Diabetes (T1D). Recent advancements in therapy have highlighted the need to address issues such as unexplained hyperglycemia and IIS occlusion.ObjectiveTo investigate the adverse events (AEs) associated with IIS that impact the treatment of T1D, with a specific focus on promoting effective educational practices.MethodsOne hundred and eighteen patients under treatment at the Diabetes Center Insulin Pump Ambulatory, Federal University of São Paulo responded to a semi-structured questionnaire. Over 6 months, a nurse researcher interviewed them via video calls.ResultsCatheter-related adverse events (AEs) included catheter knots, folding, and accidental traction. AEs associated with cannula use were mainly related to cannula fixation adhesive, insulin leakage, bleeding episodes, and skin problems. The cannula patch tends to detach easily in hot conditions or when used for more than 3 days, leading to local itching. Adhesive glue can cause redness and pain. Insulin leakage typically occurs after the catheter disconnects from the cannula, accidental cannula traction, or beneath the cannula patch. Bleeding has been reported inside the cannula or at the insertion site, resulting in local pain and, in some cases, obstruction of insulin flow. When accidental cannula traction occurs, it is recommended to replace the entire IIS system. In situations involving bleeding, leakage, insulin odor, or unsuccessful attempts to correct hyperglycemic episodes with a “bolus” of insulin, it is advisable to change the IIS system and evaluate appropriate techniques for handling and infusing the device. Moreover, regular inspections of the device and reservoir/cartridge are essential.ConclusionSerious AEs can occur even in cases where the occlusion alarm is not activated, leading to interruptions in insulin flow. Conversely, in less severe situations, alarm activation can occur even in the absence of insulin flow interruption. Accidental catheter traction and catheter bending are commonly encountered in everyday situations, while issues related to the cannula directly affect blood glucose levels. AEs related to the IIS cannula often involve insulin leakage into the skin, bleeding, and skin events attributed to adhesive issues with the cannula.
Phasic and repetitive self-touch differ in hemodynamic response in the prefrontal cortex–An fNIRS study
Authors: von Au Sabrina , Helmich Ingo , Kieffer Simon , Lausberg Hedda 
Published: November 2023

IntroductionEach individual touches the own body several 100 times a day. While some researchers propose a self-regulatory function of self-touch, others report that self-touching increases nervousness. This controversy appears to be caused by the fact that researchers did not define the kind of self-touch they examined and actually, referred to different types of self-touch. Thus, kinematically defining different types of self-touch, such as phasic (discrete), repetitive, and irregular, and exploring the neural correlates of the different types will provide insight into the neuropsychological function of self-touching behavior.MethodsTo this aim, we assessed hemodynamic responses in prefrontal brain areas using functional near-infrared spectroscopy (fNIRS) and behavioral responses with NEUROGES®. Fifty-two participants were recorded during three specific kinematically types of self-touch (phasic, irregular, repetitive) that were to be performed on command. The recently developed toolbox Satori was used for the visualization of neuronal processes.ResultsBehaviorally, the participants did not perform irregular self-touch reliably. Neurally, the comparison of phasic, irregular and repetitive self-touch revealed different activation patterns. Repetitive self-touch is associated with stronger hemodynamic responses in the left Orbitofrontal Cortex and the Dorsolateral Prefrontal Cortex than phasic self-touch.DiscussionThese brain areas have been reported to be associated with self-regulatory processes. Furthermore, irregular self-touch appears to be primarily generated by implicit neural control. Thus, by distinguishing kinematically different types of self-touch, our findings shed light on the controverse discussion on the neuropsychological function of self-touch.
Effects of loading positions on the activation of trunk and hip muscles during flywheel and dumbbell single-leg Romanian deadlift exercises
Authors: Mo Ryan Chun Yin , Ngai Derrick Chung Wang , Ng Chapman Cheuk Man , Sin Kenson Ho Sang , Luk Jim Tze Chung , Ho Indy Man Kit 
Published: November 2023

Objective: The study compared the activities of the surface electromyography (sEMG) of trunk and hip muscles during single-leg Romanian deadlift (SLRDL) exercises using a flywheel and dumbbell with different loading positions (ipsilateral and contralateral).Method: Twelve active male subjects with at least 2 years of strength training experience (age: 26.7 ± 3.3 years; weight: 73.9 ± 6.2 kg) participated in this study. sEMG in the percentage of maximum voluntary isometric contraction of four SLRDL exercises (ipsilateral and contralateral loading position for dumbbell and flywheel) in a randomized order for superior gluteus maximus (SGM), inferior gluteus maximus (IGM), gluteus medius (GM), biceps femoris (BF), erector spinae (ES), external oblique (EO), and adductor longus (AL) were measured. One-way repeated measure ANOVA with Bonferroni adjustment (statistical significance at 0.05) and the non-clinical magnitude-based decision with a standardized difference were performed for statistical analysis.Results: The overall results demonstrated a very high level of SGM (105.4%–168.6%) and BF (69.6%–122.4%) muscle activities. A significant moderate increase of sEMG signals in GM, IGM, and ES (dominant side) and a large increase in SGM activity during concentric action when the loading position of flywheel SLRDL was changed from ipsilateral to the contralateral side. No significant difference was observed between flywheel and dumbbell SLRDL exercises.Conclusion: Strength coaches may adopt dumbbell or flywheel SLRDL exercises using the contralateral loading position to simultaneously strengthen the hip extensors and trunk stabilizers effectively.
Online cognitive-behavioral intervention for stress among English as a second language teachers: implications for school health policy
Authors: Eze Angela , Anyebe Mary O. , Nnamani Rebecca G. , Nwaogaidu John C. , Mmegwa Patricia U. , Akubo Esther A. , Bako Victoria N. , Ishaya Salome N. , Eze Matthew I. , Ekwueme Francis O. , Awokwe Ngozi N. , Ekwueme Uchechukwu H. , Omenma Zipporah O. , Chukwuma Joseph N. , Amujiri Benjamin A. , Bitrus Lucia A. 
Published: November 2023

IntroductionStress is one of the highest-ranked work-related injuries worldwide and has become almost universal among the Nigerian workforce. English as a Second Language (ESL) teachers face enormous work-related threats that lead to occupational stress. When ESL teachers are stressed, students' language development and entire educational progress are at risk. This is mostly underscored as English, though a second language, serves as the language of instruction in Nigerian schools. As a result, managing occupational stress is particularly important for ESL teachers, as it is among the definitive ways of improving ESL learning and overall educational outcomes. This study examined the effectiveness of online cognitive behavioral intervention (o-CBI) in lowering occupational stress among ESL teachers.MethodESL teachers with at least 1 year of experience were among the participants (N = 89). Participants were divided into two groups: the intervention group (N = 44) and the control group (N = 45). For 9 weeks, the experimental group engaged in nine sessions of 2 h of the o-CBI program. The Single Item Stress Questionnaire (SISQ), the Satisfaction with Therapy and Therapist Scale-Revised (STTS–R), and the Teachers' Stress Inventory (TSI) were the measures used to collect primary and secondary data. Four sets of data were collected at baseline, post-test, and follow-up 1 and 2 evaluations. The data were analyzed using mean, standard deviation, t-test statistics, repeated measures ANOVA, and bar charts.Results and discussionCompared to the control group, the o-CBT group had significantly lower TSI scores at the post-test (Time 2) and follow-up evaluations (Times 3 and 4). Between pre-, post-, and follow-up 1 and 2 measurements, there were no significant differences in occupational stress index scores in the control group. It was concluded that o-CBI is effective in job-stress treatment among ESL teachers. In addition, implications for school health policy are discussed. The o-CBI for occupational stress was well received by the participants, showing high acceptability among ESL teachers.
Delivery of a community-based peer mentorship program for people with spinal cord injury at a rehabilitation center
Authors: Shi Zhiyang , Comeau Jacques , Bloom Gordon A. , Gainforth Heather , Thomas Aliki , Sweet Shane N. 
Published: November 2023

IntroductionCommunity-based spinal cord injury (SCI) organizations deliver peer mentorship programs in rehabilitation settings. Little is known on how these programs are delivered through the collaboration between community-based SCI organizations and rehabilitation institutions. This study aimed to identify barriers, facilitators, and collaboration processes within a SCI peer mentorship program provided by a community-based organization at a rehabilitation center.MethodsA qualitative case study design was applied. Seven participants were recruited, including two mentees, two mentors, one program director of the community-based SCI organization, and two healthcare professionals of the rehabilitation center. Each participant completed a one-on-one interview. Data were analyzed inductively and deductively based on the Consolidated Framework for Implementation Research (CFIR).ResultsTen factors were identified to influence the delivery of the peer mentorship program, including nine CFIR constructs. Successful delivery of the program required strong, collaborative inter-professional relationships between health professionals and community organizational staff (e.g., peer mentors) as facilitators; whereas potential cost, minimal patient needs, and limited mentor resources were found to be barriers. Engaging health professionals by initiating communications, reflecting and evaluating the program collectively with health professionals were important collaboration processes for the community-based organization to maintain effective partnership with the rehabilitation center.DiscussionThe collaboration processes and strategies to addressing/leveraging the barriers and facilitators may inform evidence-based practice to establish and optimize the delivery of SCI peer mentorship programs in various rehabilitation settings.
De monstruos, fantasmas y héroes del “progreso”. Contar historias para la vida en Patagonia
Authors: Martínez Wong Ayleen 
Published: November 2023

¿Cuáles son los peligros de contar una única historia? ¿Qué voces e historias se pierden en esta narrativa? Importa qué historias contamos para narrar con ellas otras historias; importan los conceptos que utilizamos para pensar con ellos otros mundos e importan las imágenes que vemos, para crear con ellas otras imágenes. A través del enfoque multisituado-multiespecie y las prácticas SF de Ciencia Ficción, Feminismo Situado, Fabulación Especulativa y las Figuras de Cuerda, busco desarmar y rearmar el anudamiento de historias de la vida para seguir juntxs, multiplicando los mundos presentes en los relatos de los viajeros y exploradores que estuvieron en el territorio de la Patagonia en Chile en los siglos XIX y primera mitad del siglo XX y que describieron su paisaje, participando de esta forma, en la construcción de la historia natural, una narrativa hegemónica. Contar historias para la vida en Patagonia, es abrir una historia contada por héroes del “progreso”, para dar voz y lugar a aquellas existencias monstruosas y fantasmagóricas que viven y mueren más allá de la relación que separa la cultura de la naturaleza.