bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry
Authors: Lopalco Giuseppe , Morrone Maria , Atzeni Fabiola , Bazzani Chiara , Bianchi Francesco Paolo , Cantatore Francesco Paolo , Caporali Roberto , Carletto Antonio , Cauli Alberto , Chimenti Maria Sole , Colella Sergio , Conti Fabrizio , Corrado Addolorata , Favalli Ennio Giulio , Floris Alberto , Fornaro Marco , Foti Rosario , Foti Roberta , Fracassi Elena , Frediani Bruno , Gentileschi Stefano , Gorla Roberto , Gremese Elisa , Praino Emanuela , Ramonda Roberta , Rotondo Cinzia , Sebastiani Marco , Semeraro Angelo , Ferraccioli Gianfranco , Lapadula Giovanni , Iannone Florenzo 
Published: January 2025

Background: Randomized clinical trials have demonstrated the efficacy of secukinumab (SECU) in reducing disease activity in psoriatic arthritis (PsA), while real-world studies prove a broader perspective on SECU’s usefulness in everyday clinical practice. Objectives: To assess the effectiveness of SECU by evaluating drug survival and identifying potential predictors of clinical response and treatment discontinuation in patients with moderate-to-severe PsA, using real-world data from the Italian Group for the Study of Early Arthritis (GISEA) registry. Design: This longitudinal retrospective study included PsA patients treated with SECU, spanning from May 2016 to November 2023. Methods: Data from 1045 PsA patients, including 783 with peripheral-only PsA (perPsA) and 262 with peripheral and axial involvement (mixed PsA) were analyzed. Drug survival was estimated by Kaplan–Meier analysis. Clinical outcomes, including Disease Activity Index for Psoriatic Arthritis (DAPSA), Psoriasis Area Severity Index (PASI), Ankylosing Spondylitis Disease Activity Score (ASDAS, C-Reactive Protein (CRP)-based), and Visual Analogue Scale (VAS) measures, were evaluated at baseline and at 6, 12, and 24 months. Adjusted hazard ratios (aHRs) for discontinuing SECU were determined using multivariate Cox regression models. Results: SECU survival at 24 months was 63.24%, significantly higher in mixed PsA compared to perPsA ( p = 0.036). In the overall PsA population, DAPSA scores decreased significantly at 6 months, and further at 24 months (all p < 0.0001). In mixed PsA, ASDAS-CRP scores were significantly reduced at 6 months and remained stable through 24 months (all p < 0.0001). VAS pain scores also improved already at 6 months and continued to improve at 24 months (all p < 0.0001). Higher age (aHR = 0.98, 95% confidence interval (CI): 0.96–0.99, p = 0.007) and lower baseline DAPSA scores (aHR = 1.02, 95% CI: 1.01–1.03, p = 0.014) were associated with greater persistence of SECU treatment. SECU was well tolerated, with no serious adverse events. Conclusion: SECU showed sustained clinical improvements in both peripheral and axial involvement of PsA patients over 24 months, with higher persistence observed in mixed PsA patients. Our findings highlight the favorable clinical and safety profile of SECU in real world.
Implementing a teleophthalmology referral platform in routine practice: Understanding a digital health intervention implementation using normalisation process theory
Authors: Abdi Sarah , Patel Dilisha , Carmichael Josie , Balaskas Konstantinos , Blandford Ann 
Published: January 2025

Objective Digital health interventions have the potential to improve clinical processes and patient outcomes; however, many face challenges during the adoption and implementation stages, hindering their overall impact. Our study uses normalisation process theory (NPT) as a theoretical approach to explore the facilitators and barriers to the implementation of a teleophthalmology referral platform in the United Kingdom, as an illustrative case of the implementation of a digital health intervention in routine practice. Methods Semistructured interviews were conducted with 24 health professionals (18 optometrists and 6 ophthalmologists) involved in the implementation of a teleophthalmology referral platform. NPT guided data collection and analysis. Results Most participants were ready to engage with the teleophthalmology referral platform, recognising its potential value and benefits. However, during implementation, participants’ perceptions varied; a major factor was whether their expectations from the technology were met, particularly regarding the feedback from the secondary eye care component of the referral platform. Several additional factors were identified that would influence the adoption of the platform. These included individual aspects (e.g. participants’ IT skills), technology-related factors (e.g. the time required to complete referrals) and organisational factors (e.g. investment in community optometry services). Conclusions To successfully implement the teleophthalmology platform into routine practice, particularly on a large scale, multiple factors at different levels must be considered. This study highlights the complexity associated with implementing digital health interventions in routine practice and the contribution of NPT in untangling some of these complexities.
Performance assessment of ChatGPT 4, ChatGPT 3.5, Gemini Advanced Pro 1.5 and Bard 2.0 to problem solving in pathology in French language
Authors: Tarris Georges , Martin Laurent 
Published: January 2025

Digital teaching diversifies the ways of knowledge assessment, as natural language processing offers the possibility of answering questions posed by students and teachers. Objective This study evaluated ChatGPT's, Bard's and Gemini's performances on second year of medical studies’ (DFGSM2) Pathology exams from the Health Sciences Center of Dijon (France) in 2018–2022. Methods From 2018 to 2022, exam scores, discriminating powers and discordance rates were retrieved. Seventy questions (25 first-order single response questions and 45 second-order multiple response questions) were submitted on May 2023 to ChatGPT 3.5 and Bard 2.0, and on September 2024 to Gemini 1.5 and ChatGPT-4. Chatbot's and student's average scores were compared, as well as discriminating powers of questions answered by chatbots. The percentage of student–chatbot identical answers was retrieved, and linear regression analysis correlated the scores of chatbots with student's discordance rates. Chatbot's reliability was assessed by submitting the questions in four successive rounds and comparing score variability using a Fleiss’ Kappa and a Cohen's Kappa. Results Newer chatbots outperformed both students and older chatbots as for the overall scores and multiple-response questions. All chatbots outperformed students on less discriminating questions. Oppositely, all chatbots were outperformed by students to questions with a high discriminating power. Chatbot's scores were correlated to student discordance rates. ChatGPT 4 and Gemini 1.5 provided variable answers, due to effects linked to prompt engineering. Conclusion Our study in line with the literature confirms chatbot's moderate performance for questions requiring complex reasoning, with ChatGPT outperforming Google chatbots. The use of NLP software based on distributional semantics remains a challenge for the generation of questions in French. Drawbacks to the use of NLP software in generating questions include the generation of hallucinations and erroneous medical knowledge which have to be taken into count when using NLP software in medical education.
Efficacy of in-person and telepractice-based extended Lee Silverman Voice Treatment LOUD® on dysarthria and dysphagia in adults with cerebral palsy
Authors: Kim Kyung Min , Park Sang Ah , Hwang Seong Hye , Park Alyssia , Kim Hyang Hee , Hwang Jihye , Cho Sung-Rae 
Published: January 2025

Objective With advancements in digital health technologies, telepractice has become crucial for providing accessible medical interventions. Cerebral palsy (CP) frequently results in comorbidities including dysarthria and dysphagia, leading to restrictions in activities. This study evaluates the efficacy of both in-person and telepractice-based intensive voice therapy in improving speech, swallowing functions, and related quality of life measures in adults with CP. Methods The Lee Silverman Voice Treatment (LSVT) LOUD®, a speech-behavior therapy, was administered to 16 CP subjects (9 men and 7 women; mean age = 43.4 ± 10.43 years) via in-person extended version of LSVT LOUD® (LSVT-X), and telepractice program of LSVT-X (LSVT-X e-LOUD®). Outcomes, including maximum phonation time (MPT), voice intensity, diadochokinetic rate (DDK), Voice Handicap Index (VHI), swallowing quality of life (SWAL-QOL), and Videofluoroscopic Dysphagia Scale (VDS), were assessed pre- and post-treatment. Results Significant improvements were noted in speech functions: MPT ( p = 0.006), voice intensity ( p = 0.004), DDK /puh/ ( p = 0.043), and DDK/puh-tuh-kuh/ ( p = 0.031). Swallowing function improved significantly in the pharyngeal phase on the VDS. Quality of life measures showed improvement in physical ( p = 0.003), emotional ( p = 0.000), total score of VHI ( p = 0.001), fear ( p = 0.031), sleep ( p = 0.013), fatigue ( p = 0.003), and total score of SWAL-QOL ( p = 0.019). These improvements were consistent in both LSVT-X and LSVT-X e-LOUD® groups. Conclusions Both in-person and telepractice-based LSVT-X enhance speech, swallowing functions, and quality of life in adults with CP. LSVT-X e-LOUD® can be utilized as a digital therapeutic intervention for dysphagia and dysarthria, offering accessible and flexible treatment options aligned with digital health advancements.
Validity of a smartphone application for self-monitoring psychiatric symptoms in patients with schizophrenia
Authors: Kim Sung-Wan , Kim Jae-Kyeong , Jhon Min , Kim Ju-Wan , Ryu Seunghyong , Lee Ju-Yeon , Kim Jae-Min 
Published: January 2025

Objective Despite increasing research on digital technologies for psychiatric disorders, studies specifically examining self-monitoring of symptoms with smartphone applications by patients with schizophrenia remain limited. This study aims to evaluate the validity and reliability of self-monitoring psychiatric symptoms using a smartphone application among patients with schizophrenia at Mindlink, a community-based early intervention center. Methods Fifty-three young patients with schizophrenia spectrum disorders participated. They rated their psychiatric symptoms across five domains—delusions, hallucinations, anxiety, depression, and perceived stress—using an 11-point Likert scale at baseline, 1 week, 8 weeks, and 16 weeks. Test–retest reliability was assessed using intraclass correlation coefficients (ICCs) between baseline and 1-week ratings. Concurrent validity was determined by correlating app-based ratings with established self-report and clinician-administered scales, including the Eppendorf Schizophrenia Inventory, Hamilton Program for Schizophrenia Voices Questionnaire, Beck Depression Inventory, Generalized Anxiety Disorder-7, and Perceived Stress Scale. The accuracy of the app's depression rating was assessed using receiver operating characteristic (ROC) analysis. Results ICCs for test–retest reliability were high across all symptom domains, ranging from 0.741 to 0.876 ( p < 0.001). Significant correlations were observed between app-based ratings and formal assessments at all time points. ROC analysis for single-item self-ratings using the app yielded an area under the curve of 0.829 ( p = 0.002), indicating good accuracy. Conclusion This study demonstrates that self-monitoring of key symptoms and stress using a smartphone application is valid and reliable for patients with schizophrenia. These findings support the app's potential to enhance symptom management and enable early detection of relapse in this population.
Evaluating the Effectiveness of Parent Training Pamphlets: An Intervention Study Among Parents at Child Health Checkups
Authors: Akutsu Kazuko , Goto Aya , Abo-Rass Fareeda , Yokoyama Hiroyuki 
Published: January 2025

Introduction: Parent training (PT) programs are recognized as effective interventions that enhance parenting techniques and improve the parent-child relationship. In Japan, these programs are increasingly implemented to help parents manage behavioral issues in children. This study evaluated the effectiveness of PT pamphlets designed and distributed in Shioya Town, Japan, by comparing outcomes between the intervention and control groups and within subgroups of parents, categorized based on their children’s need for follow-up health checkups. Methods: The study included an intervention group that received PT pamphlets during their 1.5-year health checkups and a control group that did not. Data were collected through self-administered questionnaires at the 3.5-year health checkups, assessing adherence to 3 recommended parenting techniques. The analysis focused on comparing intervention and control groups, evaluating adherence to 2 recommended parenting techniques versus one or none. The study also analyzed adherence to each recommended parenting technique within subgroups of parents whose children needed follow-up health checkups and those whose children did not. Results: The study included 114 participants, with 55 in the intervention group and 59 in the control group. Analysis revealed that 29.1% of the intervention group adhered to 2 recommended parenting techniques, compared with 24.6% in the control group. However, no significant differences were observed between the intervention and control groups in adherence to 2 recommended techniques versus one or none, or to any single technique among the 3. Subgroup analyses revealed significant differences in adherence among parents whose children were identified to have developmental concerns at the 1.5-year health checkup and were required to have follow-up checkups, specifically in the “avoid immediate reactions” approach between intervention and control groups. Conclusions: The PT pamphlets effectively increased adherence to recommended parenting techniques in the intervention group among children requiring follow-ups. This underscores the importance of culturally adapted PT programs and demonstrates the potential of simple educational interventions in improving parenting styles.
The Influence of Domestic Players on the Success in National and International Competitions in Football
Authors: Varmus Michal , Boško Pavol , Adámik Roman , Toman Dominika , Elkhwesky Zakaria 
Published: January 2025

Sport is an integral part of modern people’s lives. However, it is also an important business area requiring specific management approaches. This article focuses on the issues of sports management and human capital. The main goal was to analyse the influence of domestic and foreign athletes playing football in teams in the best national leagues on the success in national and international competitions (UEFA Euro, FIFA World Cup). The analysis was based on panel data from five selected countries (England, Germany, Italy, Spain, and France) in the seasons from 2009/10 to 2018/19. The research sample included 980 football teams. The hypotheses were focused on the impact of the percentage of domestic and foreign athletes and their presence in the matches on the success of the clubs and teams in the selected competitions. These were tested using a statistical algorithm including the Pooled linear regression model, Fixed effects models, Random effects models, and the ANOVA test. Main findings confirmed that if there is an effort to have more domestic players on the rosters, this has a positive effect on the success in the national league. They also revealed that the clubs and teams use the proportion of domestic and foreign athletes and their deployment in the matches as a crucial decision within the human capital management. The study draws the conclusion that clubs and associations should create opportunities for the domestic athletes in the matches to support their growth with positive effects on sport success, national pride, and fans’ satisfaction. JEL Classification: C12, Z2, L83, O52, O15, C23.
Practice patterns and outcomes of conventional versus split-dose cisplatin in neoadjuvant ddMVAC in bladder cancer
Authors: Callihan Eryn B , Kuna Elizabeth Molina , Eule Corbin J , Kessler Elizabeth R , Flaig Thomas W 
Published: January 2025

Background The practice patterns and efficacy of ddMVAC administered with split-dose cisplatin for patients with muscle-invasive bladder cancer (MIBC) remains largely undefined. Objective To characterize the application and overall survival (OS) in patients with MIBC receiving conventional ddMVAC versus split-dosed ddMVAC and to examine the predictive variables in those receiving split-dosed cisplatin. Methods Using data from the CancerLinQ Discovery database, we identified 626 patients with bladder cancer between 2000–2023 with receipt of ddMVAC. The primary outcome was OS by receipt of split-dose versus conventional ddMVAC. A secondary outcome of interest assessed predictors of receipt of split-dose ddMVAC. Use of split-dose versus conventional ddMVAC was compared using chi-square tests. Univariate and multivariable OS were estimated using Cox proportional hazards models. Predictors of receipt of split dose versus conventional ddMVAC were estimated using logistic regression models. Results Most patients with MIBC are treated with standard dose ddMVAC. In multivariate analysis, no statistically significant difference in OS was observed between split-dose and conventional ddMVAC (HR 1.3, CI 0.78–2.18, p = 0.316). We demonstrate a notable decline in the use of split-dose cisplatin over time. Baseline GFR and performance status were not predictors of split-dosing in this cohort. Conclusions Most patients with MIBC received conventional ddMVAC with decreasing frequency of split-dose cisplatin use over time. We did not observe a difference in OS between patients with MIBC who received standard versus split-dose cisplatin.
Evolving racial/ethnic disparities in AML survival in the novel therapy era
Authors: Wang Xin , Gimotty Phyllis A. , Matthews Andrew H. , Mamtani Ronac , Luger Selina M. , Hexner Elizabeth O. , Babushok Daria V. , McCurdy Shannon R. , Frey Noelle V. , Bruno Ximena Jordan , Gill Saar , Martin Mary Ellen , Paralkar Vikram R. , Maillard Ivan , Porter David L. , Loren Alison W. , Perl Alexander E. , Pratz Keith W. , Getz Kelly D. , Lai Catherine 
Published: January 2025

Abstract
Little is known about the impact of recent advances in acute myeloid leukemia (AML) treatment on racial/ethnic disparities in survival outcomes. We performed a retrospective cohort study of patients with newly diagnosed AML using data from a nationwide electronic health record–derived deidentified database. Patients were categorized based on their diagnosis date relative to venetoclax approval, as pre–novel therapy era (Pre era; 2014-2018; n = 2998) or post–novel therapy era (Post era; 2019-2022; n = 2098). Patients in the Post era were older and had more comorbidities than Pre era. Non-Hispanic Black (NHB) and Hispanic patients were younger and more likely to have lower socioeconomic status than non-Hispanic White (NHW) patients, with no differences in the distributions of key disease features. After accounting for age and comorbidity, overall survival (OS) was higher in patients in Post era than Pre era (adjusted hazard ratio [aHR], 0.90; 95% confidence interval [CI], 0.83-0.96). In Pre era, NHB had a 22% higher hazard of death than NHW (aHR, 1.22; 95% CI, 1.04-1.43), whereas worse OS was not observed for NHB in Post era (aHR, 0.86; 95% CI, 0.69-1.08; predicted 2-year survival, 45.3% vs 39.9%). Utilization of novel therapeutics in frontline therapy did not differ by race/ethnicity. Among patients receiving venetoclax-based induction, particularly those without TP53, RAS, or FLT3-ITD mutations, results suggested higher OS for NHB than NHW patients (aHR, 0.67; 95% CI, 0.45-1.01). Additional studies are needed to elucidate factors contributing to these observed survival differences and to inform strategies to optimize outcomes for all patients with AML.
Wasted ventilation in mild COPD: protocol for a clinical physiology and functional imaging study
Authors: James Matthew D. , Voskrebenzev Andreas , Klimes Filip , Zanette Brandon , Alosta Karam , Hijleh Abed A. , Vincent Sandra G. , Domnik Nicolle J , Phillips Devin B. , Pourafkari Marina , Wang Chu-Yi , Girardi Michele , Ferguson Carrie , Kirby Miranda , Santyr Giles , Stringer William , Porszasz Janos , O'Donnell Denis E , Vogel-Claussen Jens , Neder J Alberto 
Published: January 2025

BackgroundHigh ventilation (VE)-CO2output (VCO2), signaling increased wasted ventilation in the physiological dead space (VDphys), has a dominant role in eliciting activity-related dyspnoea in subjects with chronic obstructive pulmonary disease (COPD) showing only mild airflow obstruction. Exposing the mechanisms driving wasted ventilation is key to advancing the field towards new therapeutic approaches to improve dyspnoea and exercise tolerance in this growing patient sub-population.Study's central hypothesisIncreased areas of high alveolar ventilation (VA)/capillary perfusion (Qc) due to impaired Qcin non-emphysematous, non-air trapping areas of the lungs add to any underlying emphysema to increase wasted ventilation and exertional dyspnoea in mild COPD.MethodsForty patients (20 women) showing post-bronchodilator FEV1≥70% predicted and 20 sex- and age-matched controls will perform constant load exercise tests in a flutter-kicking device in the physiology laboratory and, in another visit, in a magnetic resonance imaging (MRI) facility. Volumetric capnography will be used to breath-by-breath quantify rest and exercise VDphys. Free-breathing, non-contrast proton MRI (phase-resolved functional lung (PREFUL)) VA, Qc, and VA/Qc,maps will be co-registered to emphysema and air trapping severity and distribution as established by computed tomography (parametric response mapping).Study implicationsConfirmation of the study's main hypothesis will provide the first evidence that increased wasted ventilation in dyspneic patients with mild COPD is not a mere consequence of emphysematous destruction being also reflective of impaired perfusion across apparently preserved lung tissue. This will set the stage for subsequent interventional studies geared to address this potentially treatable disease trait.