bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of vericiguat in management of patients with heart failure with reduced ejection fraction after worsening episode
Authors: Olivella Aleix , Almenar‐Bonet Luis , Moliner Pedro , Coloma Emmanuel , Martínez‐Rubio Antoni , Paz Bermejo Marco , Boixeda Ramon , Cediel German , Méndez Fernández Ana Belén , Facila Rubio Lorenzo 
Published: December 2023

AbstractWorsening heart failure (HF) is a vulnerable period in which the patient has a markedly high risk of death or HF hospitalization (up to 10% and 30%, respectively, within the first weeks after episode). The prognosis of HF patients can be improved through a comprehensive approach that considers the different neurohormonal systems, with the early introduction and optimization of the quadruple therapy with sacubitril–valsartan, beta‐blockers, mineralocorticoid receptor antagonists, and inhibitors. Despite that, there is a residual risk that is not targeted with these therapies. Currently, it is recognized that the cyclic guanosine monophosphate deficiency has a negative direct impact on the pathogenesis of HF, and vericiguat, an oral stimulator of soluble guanylate cyclase, can restore this pathway. The effect of vericiguat has been explored in the VICTORIA study, the largest chronic HF clinical trial that has mainly focused on patients with recent worsening HF, evidencing a significant 10% risk reduction of the primary composite endpoint of cardiovascular death or HF hospitalization (number needed to treat 24), after adding vericiguat to standard therapy. This benefit was independent of background HF therapy. Therefore, optimization of treatment should be performed as earlier as possible, particularly within vulnerable periods, considering also the use of vericiguat.
Changes over time in patient‐reported outcomes in patients with heart failure
Authors: Jaarsma Tiny , Kato Naoko P. , Klompstra Leonie , Ben Gal Tuvia , Boyne Josiane , Hägglund Eva , Vellone Ercole , Hagenow Andreas , Evangelista Lorraine S. , Mårtensson Jan , Strömberg Anna 
Published: December 2023

AbstractAimThis paper describes the trajectory during 1 year of four patient‐reported outcomes (PROs), namely, sleep, depressive symptoms, health‐related quality of life (HrQoL), and well‐being, in patients with heart failure (HF), their relationship and the patient characteristics associated with changes in these PROs.Methods and resultsData analyses of PROs from 603 patients (mean age 67 years; 29% female, 60% NYHA II) enrolled in the HF‐Wii study. On short term, between baseline and 3 months, 16% of the patients experienced continuing poor sleep, 11% had sustained depressive symptoms, 13% had consistent poor HrQoL, and 13% consistent poor well‐being. Across the entire 1‐year period only 21% of the patients had good PRO scores at all timepoints (baseline, 3, 6, and 12 months). All others had at least one low score in any of the PROs at some timepoint during the study. Over the 12 months, 17% had consistently poor sleep, 17% had sustained symptoms of depression, 15% consistently rated a poor HrQoL, and 13% poor well‐being. Different patient characteristics per PRO were associated with a poor outcomes across the 12 months. Age, education, New York Heart Association, and length of disease were related to two PRO domains and submaximal exercise capacity (6 min test), co‐morbidity, and poor physical activity to one.ConclusionIn total, 79% of the patients with HF encountered problems related to sleep, depressive symptoms, HrQoL, and well‐being at least once during a 1‐year period. This underscores the need for continuous monitoring and follow‐up of patients with HF and the need for dynamic adjustments in treatment and care regularly throughout the HF trajectory.
Effect of constipation on readmission for heart failure in patients with acute heart failure
Authors: Namiuchi Shigeto , Tanita Atsushi , Sunamura Shinichiro , Onodera Kenta , Ogata Tsuyoshi , Noda Kazuki , Takii Toru , Nitta Yoshio , Yoshida Seijiro 
Published: December 2023

AbstractAimsConstipation is a common gastrointestinal disorder that is associated with a high cardiovascular event rate in the general population. Although constipation is common in patients with cardiovascular diseases, only a few studies have examined the relationship between constipation and the prognosis of patients with heart failure. This study aimed to evaluate the effects of constipation on the prognosis of patients with acute heart failure.Methods and resultsWe investigated 397 patients admitted to our hospital from December 2020 to December 2022 with acute heart failure (mean age, 81 ± 13 years; 54% men). Patients with constipation were defined as those either taking laxatives regularly or diagnosed with constipation according to the International Statistical Classification of Diseases and Related Health Problems. During the follow‐up periods (median, 173 days), 35 patients died, and 74 experienced readmission due to heart failure. Kaplan–Meier analysis before and after propensity score matching using 14 variables revealed that the risk of readmission due to heart failure was significantly higher in patients with constipation than in those without (before: log‐rank P = 0.014, after: log‐rank P = 0.0027). The adjusted Cox proportional hazards analysis revealed that the hazard ratio for readmission due to heart failure was 2.61 (95% confidence interval, 1.38–4.94, P = 0.0032). The risk of all‐cause death was not significantly different between the two groups (hazard ratio, 1.76; 95% confidence interval, 0.61–5.06; P = 0.30).ConclusionsConstipation status was strongly associated with a higher risk of readmission for heart failure in patients with acute heart failure.
Identifying stories of ‘us’: A mixed‐method analysis of the meaning, contents and associations of national narratives constructed by Americans
Authors: Choi Sarah Y. , Liu James H. 
Published: December 2023

AbstractHow do lay individuals reconstruct, appropriate or resist culturally sanctioned narratives about their nation's past? The current study examined this question through an open‐ended survey administered to a US sample, stratified by age and gender (N = 399). We identified three major historical narratives that were popular among Americans. Specifically, we identified positive narratives of the nation's progress over time and glorifying narratives of American exceptionalism, alongside a popular counter‐narrative that was critical of the nation as reproducing ongoing cycles of injustice. Representations of national origins were significantly more salient for the narratives of Progress and Glorification, while more recent and lived events were salient for Critical narratives. Progress and Critical narratives were both associated with a constructive orientation to national identity, while Glorifying narratives were associated with blind patriotism. Critical and Glorifying narratives were consistently opposed in their associated political attitudes and in their patterns of endorsement across party affiliations. Overall, it appeared that narratives of progress were most popular and least polarised. We discuss the implications of these findings through the perspective that narratives provide dynamic content for identity construction as well as the means for articulating resistance to hegemony within specific historical and political contexts.
Associations of orientation to promote good in challenging situations with distress and well‐being: Multi‐study evidence from three non‐Western Longitudinal samples
Authors: Weziak‐Bialowolska Dorota , Cowden Richard G. , Cook Kaye V. , Bialowolski Piotr , Bechara Andrea Ortega , Chen Zhuo Job , Kurniati Ni Made Taganing , Suwartono Christiany , McNeely Eileen , VanderWeele Tyler J. 
Published: December 2023

AbstractWe examine whether an orientation to promote good serves as a potential buffer against distress and facilitator of well‐being outcomes in three non‐Western samples with a recent history of conflict (Indonesia, Colombia, Mexico) and across three different time frames (1, 4 and 12 months). Longitudinal surveys provided data for cross‐lagged panel modelling. A series of sensitivity analyses provided evidence for the robustness of results. Persons with an orientation to promote good reported greater well‐being 1 month and 4 months post‐assessment and reduced distress 1 month and 4 months post‐assessment. The effects, with larger effect sizes, were also found for reverse associations. We did not find evidence of associations assessed at the 12‐month interval with the exception of a negative association between an orientation to promote good and subsequent life satisfaction and happiness. Orientation to promote good may be relevant for population's mental health and well‐being over the short‐ and medium‐term.
Progress in MXene‐based catalysts for oxygen evolution reaction
Authors: Chen Jieli , Gao Xiaohong , Li Jing , Kang Zhenye , Bai Juan , Wang Tianjiao , Yuan Yuliang , You Chenghang , Chen Yu , Xia Bao Yu , Tian Xinlong 
Published: December 2023

AbstractElectrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen fuel. However, the anodic oxygen evolution process remains a bottleneck due to the remarkably high overpotential of about 300 mV to achieve a current density of 10 mA cm−2. The key to solving this dilemma is the development of highly efficient catalysts with minimized overpotential, long‐term stability, and low cost. As a new 2D material, MXene has emerged as an intriguing material for future energy conversion technology due to its benefits, including superior conductivity, excellent hydrophilic properties, high surface area, versatile chemical composition, and ease of processing, which make it a potential constituent of the oxygen evolution catalyst layer. This review aims to summarize and discuss the recent development of oxygen evolution catalysts using MXene as a component, emphasizing the synthesis and synergistic effect of MXene‐based composite catalysts. Based on the discussions summarized in this review, we also provide future research directions regarding electronic interaction, stability, and structural evolution of MXene‐based oxygen evolution catalysts. We believe that a broader and deeper research in this area could accelerate the discovery of efficient catalysts for electrochemical oxygen evolution.
Pore characteristics and mechanical behaviors of autoclaved aerated concrete produced from coal bottom ash and tailings
Authors: Zhang Mingyuan , Yao Huayan , Liu Yuting , Gan Jiarui , Tang Lingxiao 
Published: December 2023

AbstractThe solid wastes such as coal bottom ash and tailings are currently widely used in various building materials, but further research on their application in autoclaved aerated concrete (AAC) is needed. To study the physical and mechanical properties of AAC produced from coal bottom ash and tailings, the pore characteristics of two different density grades of AAC were extracted and analyzed, and wave velocity and uniaxial compressive tests under water‐saturated and dry conditions were carried out. The results show that the AAC produced from solid waste has excellent performance. The specimen is anisotropic, and the pore size distribution of its cross‐section is mainly concentrated in the ranges of <0.1, 0.1–0.5, and 0.5–1.0 mm. The pore size perpendicular to the direction of rise is smaller and the pores number is greater. The wave velocity and uniaxial compressive strength of the test specimens in the water‐saturated state are significantly lower than those in the dry state. The strengths of specimens loaded perpendicular to the direction of rise are higher than those loaded parallel to the direction of rise whether water‐saturated or dry. The failure mode of the water‐saturated specimens are different from those of dry specimens, which is manifested in the act that there are fewer surface cracks when the specimens fail in the water‐saturated state, while there are more surface cracks in the dry specimens, and their morphology is irregular. The physicochemical effect between water and components and the mechanical effect of pore water are the reasons for the deterioration of AAC's mechanical properties. The results help to reveal the performance of AAC produced from solid waste and have good practical significance.
Advances and Applications of Metal‐Organic Frameworks (MOFs) in Emerging Technologies: A Comprehensive Review
Authors: Li Dongxiao , Yadav Anurag , Zhou Hong , Roy Kaustav , Thanasekaran Pounraj , Lee Chengkuo 
Published: December 2023

AbstractMetal‐organic frameworks (MOFs) that are the wonder material of the 21st century consist of metal ions/clusters coordinated to organic ligands to form one‐ or more‐dimensional porous structures with unprecedented chemical and structural tunability, exceptional thermal stability, ultrahigh porosity, and a large surface area, making them an ideal candidate for numerous potential applications. In this work, the recent progress in the design and synthetic approaches of MOFs and explore their potential applications in the fields of gas storage and separation, catalysis, magnetism, drug delivery, chemical/biosensing, supercapacitors, rechargeable batteries and self‐powered wearable sensors based on piezoelectric and triboelectric nanogenerators are summarized. Lastly, this work identifies present challenges and outlines future opportunities in this field, which can provide valuable references.
A panel vector autoregression analysis for the dynamics of medical and long‐term care expenditures
Authors: Sugawara Shinya , Ishihara Tsunehiro , Kunisawa Susumu , Goto Etsu , Imanaka Yuichi 
Published: December 2023

AbstractAlthough medical and long‐term care expenditures for older adults are closely related, providing rigorous statistical analysis for their dynamic relationship is challenging. In this research, we propose a novel approach using the panel vector autoregression model to reveal the realized patterns of the interdependence. As an empirical application, we analyze monthly panel data on individuals in a city of Japan, where social insurance covers many formal services for long‐term care. Our estimation results indicate the existence of intertemporal transition from expensive acute medical care to reasonable at‐home medical care, then to at‐home long‐term care. Under this context, the enhancement of formal long‐term care sector in Japan might have played an important role in the suppression of the total care cost in spite for its rapid aging over the past 2 decades. Additionally, we find that daycare plays multiple roles in Japanese long‐term care, such as respite and rehabilitation, but there is no considerable transition from outpatient rehabilitation to daycare in the long‐term care sector.
Evaluating the utility and validity of a discrimination‐specific measure of shift‐&‐persist coping
Authors: Christophe N. Keita , Martin Romero Michelle Y. , Stein Gabriela L. 
Published: December 2023

AbstractShift‐&‐persist (S&P) coping has been shown to buffer against the effects of discrimination on psychosocial functioning in racially and ethnically minoritized youth. However, existing measures of S&P refer broadly to coping with stress and are not specifically tailored to the type of stressor individuals are coping with (e.g., discrimination). The current study evaluated the measurement properties, utility, and validity of a discrimination‐specific adapted measure of S&P relative to an existing, general measure among a sample of 327 minoritized youth (Mage = 18.80, SD = 1.28, 78.6% female, 50.5% Black) recruited from a large public minority‐serving institution in the southeastern United States. Contrary to our hypotheses, when the item stem was changed to refer to coping specifically with discrimination, the measurement properties of a validated S&P scale (Lam et al., 2018) were worse relative to the original measure. Overall, the general S&P measure produced larger main effects and explained two times more variance in depressive symptoms than discrimination‐specific S&P. Findings do not rule out the idea that context‐specific measures may better characterize coping with discrimination experiences than ‘trait‐like’ general coping measures. However, results highlight that small adaptations to current measures may not be sufficient and may compromise predictive validity. Coping with discrimination measurement recommendations is discussed.
UGT1A1 genotype‐guided irinotecan dosing during neoadjuvant chemoradiotherapy for locally advanced rectal cancer: A prospective analysis of SN‐38 concentration
Authors: Jiang Pei‐Cheng , Wang Shuo‐Wen , Li Chao , Fan Jin , Zhu Ji 
Published: December 2023

AbstractIrinotecan plays a crucial role in the neoadjuvant chemoradiotherapy (nCRT) of rectal cancer, but its optimal dosing is still unclear. In this study, we included 101 eligible patients with the UGT1A1*28 genotype of UGT1A1*1*1 (74.3%) and UGT1A1*1*28 (25.7%) and UGT1A1*6 genotypes of GG (63.4%), GA (32.7%), and AA (3.9%). All patients received preoperative radiotherapy (50 Gy/25 fractions) with concurrent irinotecan (UGT1A1*1*1: 80 mg/m2; UGT1A1*1*28: 65 mg/m2) and capecitabine (CapIri). SN‐38 concentrations were measured at 1.5, 24, and 49 h post‐administration. Patients were divided into four groups (Q1–Q4) based on the SN‐38 concentration. The complete‐response (CR) rate was the primary endpoint. The analysis demonstrated that the 49 h SN‐38 concentration was relatively optimal for predicting efficacy and toxicity. The Q4 group had a significantly higher CR rate than the Q1 group (p = .019), but also higher rates of adverse events (p = .009). We screened the recommended 49 h SN‐38, with a 0.5–1.0 ng/mL concentration range. We also validated the correlation between UGT1A1*6 polymorphism and SN‐38 concentration, along with the clinical efficacy of irinotecan. In conclusion, our study identified the relatively optimal timepoint and concentration range for monitoring SN38 concentrations and revealed the clinical significance of UGT1A1*6 and UGT1A1*28 polymorphisms in guiding irinotecan administration, offering meaningful insights for personalised irinotecan dosing.
Evaluating the efficacy and generality of a skill‐based approach for promoting universal behavioral readiness
Authors: Rahaman Javid A. , Luczynski Kevin C. 
Published: December 2023

AbstractBehavioral readiness can take the form of communication and self‐control skills during challenging situations that are correlated with the development of problem behavior. A skill‐based approach can teach behavioral readiness using procedures that involve synthesized reinforcement, probabilistic reinforcement, and contingency‐based delays; however, this approach is commonly used to address severe behavior under specific situations. There is limited research evaluating a skill‐based approach to teaching behavioral readiness and addressing emerging problem behavior. Also, it is unclear whether teaching effects under specific situations transfer across other, functionally distinct, situations. We evaluated the generality of a skill‐based approach by teaching skills systematically across primary challenging situations involving the interruption of play, presentation of instructions, and removal of reinforcers. Teaching increased communication and self‐control skills, and most skills transferred to secondary challenging situations (treatment extension probes) and caregiver‐implemented sessions. We discuss challenging situations that required teaching, the generality of teaching, and procedural considerations.
miRNA‐211‐5p inhibition enhances the protective effect of hucMSC‐derived exosome in Aβ1‐40‐induced SH‐SY5Y cells by increasing NEP expression
Authors: Chen Huijing , Huang Zhongqin , Lei Aidi , Yu Xiaowen , Shen MeiLing , Wu Dan 
Published: December 2023

AbstractExosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) could alleviate Alzheimer's disease (AD) defects. Additionally, engineered exosomes are more effective in treating diseases. In this study, we established an in vitro model of AD by treating SH‐SY5Y cells with Aβ1‐40. We observed that incubation with hucMSC‐derived exosomes effectively protected SH‐S5Y5 cells from Aβ1‐40‐induced damage. Since NEP plays a central role in suppressing AD development, we screened NEP‐targeting miRNAs that are differentially expressed in control and AD patients. We identified miR‐211‐5p as a potent repressor of NEP expression. Exosomes purified from hucMSCs overexpressing miR‐211‐5p inhibitor exhibited significantly greater efficiency than control exosomes in mitigating the injury caused by Aβ1‐40 treatment. However, this enhanced protective effect was nullified by the knockdown of NEP. These observations demonstrate that inhibition of miR‐211‐5p has the potential to improve the efficacy of hucMSC‐derived exosomes in AD treatment by increasing NEP expression.
Andrographolide protect against lipopolysacharides induced vascular endothelium dysfunction by abrogation of oxidative stress and chronic inflammation in Sprague–Dawley rats
Authors: Padhy Debiprasad , Sharma Satyam , Singh Sanjiv 
Published: December 2023

AbstractThe development of heart disease involves interconnected factors such as oxidative stress, inflammation, and vascular dysfunction. Andrographolide (AG), known for its potent antioxidant and anti‐inflammatory properties, has the potential to counteract lipopolysaccharides (LPS)‐induced endothelial dysfunction by reducing oxidative stress and inflammation. Our research aimed to investigate the effects of AG on alleviating vascular endothelium dysfunction, oxidative stress, and inflammation in an experimental model induced by LPS. To create chronic vascular endothelium dysfunction, inflammation, and oxidative stress, rats received weekly injections of LPS via their tail vein over a 6‐week period. The study evaluated the therapeutic effects of orally administered AG (50 mg/kg/day) on diseased conditions. We conducted aortic histology and measured nitric oxide (NO) thresholds, superoxide dismutase (SOD) activity, constitutive nitric oxide (cNOS) activity, and inducible nitric oxide (iNOS) levels, alongside several inflammatory biomarkers. To evaluate endothelial dysfunction, we assessed endothelium‐dependent and endothelium‐independent vasorelaxation in aortas through histopathological and various immunoassays examinations. Vascular Endothelial inflammatory activity was consequently enhanced in LPS groups animals when compared to normal control, also endothelial performance were dependently improved by AG therapy. IL‐1β and tumors necrosis factor levels in the aorta decreased in a dose‐dependent manner after exogenous AG delivery to LPS‐treated rats. However, in current research work aortic SOD activity, NO levels, and cNOS activity increased, whereas aortic malondialdehyde levels and iNOS activity decreased after the AG treatment. These findings suggest that long‐term AG therapy could be considered as a potential therapy to avoid vascular endothelial dysfunction and major nonobstructive coronary artery disease.