bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness to donate eyes and associated factors among adults in Addis Ababa City, Ethiopia: a mixed-methods approach
Authors: Tefera Wubalem Addis , Mengistu Hirut Gebremeskel , Zeleke Ejigu Gebeye , Lorato Merkineh Markos 
Published: January 2025

ObjectiveThis study intended to assess willingness to donate eyes and associated factors among adults in Addis Ababa City, Ethiopia.Methods and analysisThis study used a triangulated phenomenological mixed-methods design, involving 1293 adults and eight key informants selected through multistage and purposive sampling. Data collection involved a pretested, semistructured questionnaire for quantitative data and an open-ended guiding questionnaire for qualitative insights. Ethical approval was granted by the University of Gondar, School of Medicine ethics review committee. The data were entered into Epi Info V.7 and analysed using SPSSV.22, with bivariable and multivariable binary logistic regression employed to identify significant factors, defined as those with a p value under 0.05. Qualitative data were analysed through thematic content analysis using code software, which included transcription, translation, coding and thematisation, ultimately enriching the quantitative findings.Results and conclusionThe study found that 47.2% (95% CI 44.7, 50.0) participants were willing to donate their eyes. Significant factors influencing willingness included being male (adjusted OdR (AOR)=1.55; 95% CI 1.18, 2.03), being a Christian (AOR=2.08; 95% CI 1.42, 3.04), having a family or friends awaiting for corneal transplantation (AOR=1.78; 95% CI: 1.18, 2.68), completing higher education (AOR=2.63; 95% CI 1.88, 3.69), completing secondary education (AOR=1.77; 95% CI 1.03, 3.04), having a favourable attitude towards eye donation (AOR=4.97; 95% CI 3.70, 6.66) and being aware of eye donation (AOR=3.12; 95% CI 2.23, 4.36). Qualitative analysis indentified barriers such as lack of information, poor attitudes and religious restrictions.Overall, willingness to donate eyes was moderate compared to previous studies. The findings emphasise the need for community education to improve public attitudes and awareness about eye donation to enhance willingness to donate eyes.
Neonatal unit admission and offspring mental health trajectories across childhood and adolescence: a nationally representative UK cohort study
Authors: Nandakumar Madura , Lewis Gemma , Lewis Glyn , Solmi Francesca , Srinivasan Ramya 
Published: January 2025

ObjectiveTo investigate the associations between neonatal unit admission (NNU) and subsequent emotional and behavioural difficulties during childhood and adolescence.DesignLongitudinal general population cohort study.SettingThe Millennium Cohort Study: nationally representative UK-based cohort.ParticipantsAll children with exposure, outcome and confounding data.ExposureNNU admission was identified at 9 months by asking parents whether their baby was ‘taken to special care or neonatal or intensive care unit after birth’.Main outcome measuresEmotional and behavioural problems were assessed using the Strengths and Difficulties Questionnaire when children were 3, 5, 7, 11, 14 and 17 years. We explored the association between NNU admission and trajectories of emotional and behavioural problems using multilevel models with growth curves for outcome data between 3–17 years and adjusted for a broad range of confounders.Results14 013 participants (48.9% female, 13.7% ethnic minority) were included in the analytical sample. In the sample, mean gestational age was 275.81 (SD): 13.80) days, and mean birth weight was 3.36 kg (SD=0.58). 1273 (9.1%) participants had an NNU admission. The latter was associated with increased emotional difficulties (mean difference (MD) 0.13, 95% CI 0.045 to 0.22, p=0.003) and peer problems (MD 0.11, 95% CI 0.026 to 0.19, p=0.010) during childhood in fully adjusted models. There was no evidence that NNU admission was associated with conduct problems (MD 0.013, 95% CI −0.062 to 0.088, p=0.732) or hyperactivity symptoms (MD 0.042, 95% CI −0.070 to 0.15, p=0.452).ConclusionsChildren admitted to NNUs at birth are more likely to experience emotional difficulties and peer problems during childhood. These differences are apparent from early childhood continuing into adolescence and strengthen the case for a calm NNU environment with parental visits and mental health support, and early interventions for children admitted to NNUs.
Occurrence, Risk Factors, and Antibiotic Resistance Patterns of Salmonella Isolates Obtained From Dairy Farms in Gondar Town, Northwest Ethiopia
Authors: Yirsa Tsedalu , Tigistu Alene 
Published: January 2025

Background: Salmonellosis is a foodborne diarrheal disease with significant public health and economic implications for humans and animals. Nevertheless, its epidemiological effects and multidrug resistance remain poorly studied in the study area.Methods: A cross‐sectional study was conducted from March to August 2022 to determine the occurrence, risk factors, and antibiotic susceptibility patterns of Salmonella isolates in the study dairy farms. A total of 232 samples (200 study animals and 32 bulk tank milk) were collected from purposively selected dairy farms in the study area. Again, fecal and bulk tank milk samples were collected, pre‐enriched, and cultured to examine the presence of Salmonella following standard techniques. The pure 30 isolates were also subjected to a Kirby–Bauer disk diffusion test on Muller–Hinton agar to assess their antibiotic susceptibility patterns. Binary logistic regression analysis in Statistical Package for Social Sciences (SPSS) Version 25 was used to determine the strength of the risk factors associated with the occurrence of this disease.Findings: The overall prevalence of Salmonella isolates was 12.9% (30/232) across all samples. Among these, 11.5% (23/200) of the fecal samples from the study animals and 21.9% (7/32) of the bulk tank milk samples tested positive for this disease. A statistically significant association was observed between the presence of the Salmonella isolates and the age of the study animals, farm size, bedding, and udder washing practices. The isolates also showed the highest resistance to ampicillin (100%) and tetracycline (96.7%). Conversely, the isolates were most sensitive to ciprofloxacin (100%) and kanamycin (90%).Conclusions: Generally, the high presence of Salmonella isolates and its resistance to drugs pose significant economic and public health challenges. Thus, it is crucial to implement improved management practices and appropriate antibiotic therapies in the study dairy farms.
Postoperative Axial Length Prediction Model in Children With Congenital Cataract and Intraocular Lens Implantation
Authors: Xu Jialin , Yu Yunhui , Wang Yaqi , Zhang Shenrong , Liu Enze , Wang Wenjing , Zhu Chenyuan , Li Jin 
Published: January 2025

Purpose: To develop a prediction model for postoperative axial length (AL) in Asian children with congenital cataracts undergoing primary/secondary intraocular lens (IOL) implantation.Design: Retrospective observational study.Methods: Data were collected from children who underwent cataract surgery for congenital cataracts at the Eye Hospital of Wenzhou Medical University between 2006 and 2020. All participants completed preoperative and at least 1‐year of postoperative follow‐up. SPSS 26.0 software was used to analyze the variable factors affecting AL growth and the interactions among these factors. A generalized estimating equation (GEE) was employed to assess the correlation between the AL and related univariates over time. The univariate model was applied to build a multivariate model to predict the postoperative AL. Two validation sets were used to verify the accuracy of the formula.Results: The study involved 86 children, accounting for 148 eyes. The median age at the time of surgery was 3.00 years, with a median age of 9.50 years at the final follow‐up visit. The median duration of follow‐up was 5.00 years. The preoperative and final follow‐up mean ALs were 21.79 ± 1.77 and 23.36 ± 1.90 mm, respectively. Taking the predicted AL (Y) as the dependent variable and the age at surgery (X1), age at review (X2), and preoperative AL (X3) as the independent variables, the prediction model was established as Y = 0.20 − 0.473 × X1 + 0.446 × X2 + 0.993 × X3 − 0.014 × (X2 − X1)∗X2.Conclusions: This model predicts AL growth in children following congenital cataract surgery and IOL implantation, helping ophthalmologists select appropriate IOL power.
Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-label ARIVA Trial
Authors: Barco Stefano , Jalaie Houman , Sebastian Tim , Wolf Simon , Fumagalli Riccardo M. , Lichtenberg Michael , Zeller Thomas , Erbel Christian , Schlager Oliver , Kucher Nils 
Published: January 2025

Background: In patients with post-thrombotic syndrome (PTS), stent recanalization of iliofemoral veins or the inferior vena cava can restore venous patency and improve functional outcomes. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. The ARIVA trial tested whether daily aspirin 100 mg plus rivaroxaban 20 mg is superior to rivaroxaban 20 mg alone to prevent stent thrombosis within 6 months after stent placement for PTS.
Methods: In this multinational, academic, open-label, independently adjudicated trial, patients with a Villalta score >4 points, a stenosis or occlusion of the inferior vena cava, iliac veins, or common femoral vein, successfully treated with venous stent placement, were randomized in a 1:1 fashion to the study groups. Key exclusion criteria included age <18 or >75 years, contraindications to anticoagulant use or acute venous thrombosis <3 months. The primary efficacy outcome was the composite of no occlusion in the treated segment assessed at serial duplex ultrasound examinations or no re-intervention needed to maintain patency within 6 months. Secondary outcomes, including Villalta score, quality of life, and safety outcomes were also assessed. The study was registered in ClinicalTrials.gov (NCT04128956).
Results: From 2020 through 2022, 172 patients were screened, 169 randomized and 162 included in the full analysis set, receiving either aspirin plus rivaroxaban (n=80) or rivaroxaban alone (n=82) for six months. Mean age was 42.8 (standard deviation 14.7) years, 103 (60.9%) patients were women, 154 (97.5%) were Caucasian, and leg ulcers were present in 7% patients. The primary patency rate at six months was 94.8% vs. 92.4% (absolute risk difference: 2.4%; 95 %CI -13.6%; +18.0%), respectively. The mean decrease in the Villalta score for the affected leg (without ulcer) from baseline to 6 months was -6.7 (SD 4.4) and -7.0 (SD 5.2) points (p-value 0.36), respectively. There were no differences in other outcomes or quality of life at 6 months. No major bleeding occurred.
Conclusions: The overall primary patency rate during the first six months following endovascular intervention for PTS was higher than expected and comparable between patients receiving aspirin combined with rivaroxaban and those receiving rivaroxaban alone.
Not Rocket Science: A Pragmatic Checklist to Assess Readiness for Oral Feeding in Very Preterm Infants
Authors: Dinaraj Archana , Joy Anju , Pournami Femitha , Prabhakar Jyothi , Jain Naveen 
Published: January 2025

Background and Rationale Successful transition to oral feeding is a crucial milestone for preterm infants. Our unit uses a pragmatic 5-point checklist to assess the readiness of preterm infants for oral feeding. Methods This prospective observational study included very preterm infants (<32 weeks at birth). They were assessed for readiness at ≥33 weeks postmenstrual age (PMA), and pre-defined physiological stability for oral feed readiness. Oral feeds were started when all parameters of the checklist were satisfied. The proportion of those who succeeded (measured as no apnoea/choking on oral feed for 48 hours) after commencement of transitioning from orogastric to oral feeds was measured, weight gain over 1 week and PMA at attainment of full oral feeds were also analysed. Results Thirty-three eligible neonates were included, of which 26(78.8%) had no apnoea/choking within the first 48 hours of transition. Twelve infants needed to be reassessed since they ‘failed’ the first time over. The median PMA of attainment of full oral feeds was 34(34,37) weeks, weight gain over 1 week of oral feeds was 145(117,170) g. Among risk factors analysed for choking, stress signs during non-nutritive sucking [RR6(1.7–20.1), P = .002], those with initial sick newborn period (FiO2 need>0.3 beyond 72 hours/any inotrope need)[RR9.2(1.2–68.1), P = .004], and bronchopulmonary dysplasia (BPD) [RR4.2(1.3–13.3)], P = .02] were significant. Conclusion The transition to oral feeding of preterm neonates can be assessed by a practicable, easy-to-use scale; it predicted success in 78.8% infants. Those who were initially sick exhibited stress signs on assessment and BPD infants can be transitioned with due caution and monitored for choking events more closely.
Myricetin exposure reduces PC differentiation in vitro in primary human B cells
Authors: Haque Shabirul , Diamond Betty 
Published: January 2025

Abstract

Background
The process of B cell activation and plasma cell (PC) formation involves morphological, transcriptional, and metabolic changes in the B cell. Blocking or reducing PC differentiation is one approach to treat autoimmune diseases that are characterized by the presence of pathogenic autoantibodies. Recent studies have suggested the potential of myricetin, a natural flavonoid with anti-inflammatory and antioxidant properties, to block or reduce PC differentiation.

Methods
Primary human B cells were purified by using a human B cell isolation kit. B cell subsets such as IgG memory B cells, marginal zone B cells (MZ B cells), and naive B cells were isolated by flow cytometry and activated to induce PC differentiation. Quantification of PCs (CD27 + + , CD38 +) was obtained by flow cytometry. The expression of mRNA was measured by qPCR. Ig secretion in culture supernatant was measured by ELISA.

Results
Myricetin treatment significantly reduced PC differentiation in primary human B cells and all B cell subsets. Myricetin exposure reduced Ig production both IgM and IgG, in culture supernatants at day 5. Myricetin treatment led to augmented BACH2 expression and reduced IRF4, BLIMP1, and XBP1 expression compared to control cultures.

Conclusion
Myricetin treatment reduced PC differentiation and Ig secretion by primary human B cells. Targeting B cells in this way may be a therapeutic approach for some autoimmune diseases.

Graphical Abstract
A systematic review of the clinical practice guidelines for the assessment, management and treatment of eating disorders during the perinatal period
Authors: Ecob Chantelle , Smith Debbie M. , Tsivos Zoe , Hossain Noora , Peters Sarah 
Published: January 2025

Abstract

Background
Eating disorders during the perinatal period can pose significant risks to both the mother and the baby. Clinical practice guidelines include statements of expected practice intending to improve effectiveness and quality of care within health care services. This systematic review aimed to identify and synthesise current clinical practice guideline recommendations on the assessment, management and treatment of eating disorders during the perinatal period.

Methods
Three bibliographic databases and five guideline repository databases were searched alongside the grey literature. Guidelines were screened against eligibility criteria and recommendations for the assessment, management or treatment of eating disorders during the perinatal period were extracted. All included guidelines were assessed for quality using the AGREE-II tool. Recommendations were analysed and summarised using narrative synthesis.

Results
From the 242 records screened, 17 met inclusion criteria. Guideline quality ranged from three out of seven to seven out of seven. Six overall recommendations were formed from the narrative synthesis of data: 1) Early detection: recognising the signs and symptoms, 2) Assessment and screening: a three-pronged approach, 3) Educating and supporting the mother: the importance of knowledge, 4) Cross-system collaboration, 5) Psychological, pharmacological and medical treatment, and 6) Continued monitoring.

Conclusion
Perinatal eating disorder guideline recommendations were fairly consistent but showed considerable variability in quality and depth of recommendations. Recommendations require further contextualisation, to allow them to be operationalised and implemented within services. The review findings provide an initial framework for health care professionals responsible for supporting women with eating disorders during the perinatal period, and have several implications for policy, service delivery and health outcomes for women and their families.
Duration of exposure to night work and cardiovascular risk factors: results from 52,234 workers of the CONSTANCES study
Authors: Bourgkard Eve , Boini Stéphanie , Grzebyk Michel , Dziurla Mathieu , Ferrières Jean , Goldberg Marcel , Ribet Céline , Esquirol Yolande 
Published: January 2025

Abstract

Background
The cardiovascular consequences of night work are increasingly well-known. Implementing effective preventive strategies, however, requires further investigation of the effects of exposure duration. This study sought to assess the cumulative dose–effect of night work exposure on the prevalence of cardiovascular risk factors among current and former night workers in France.

Methods
We used cross-sectional data from the CONSTANCES cohort to design analyses on 52,234 workers exposed or not exposed to night work during their working life. The cumulative duration of night work exposure was assessed among permanent, rotating and former night workers. BMI, blood pressure, lipids, glycaemia and SCORE2 were measured in health screening centres.

Results
Excess risks of moderate-high SCORE2 were observed for permanent (+ 43%), rotating (+ 72%) and former night workers (+ 101%). Among male permanent night workers, excess risks for obesity (+ 76%) and central obesity (64%) were recorded at five years of exposure and for T2DM (+ 119%) at 10 years of exposure. Male rotating night workers showed excess risks at five years of exposure for obesity/central obesity (about + 45%) and high triglyceridaemia (+ 52%). Female former night workers were at excess risk at five years of exposure for obesity/central obesity (about + 45%), HBP (+ 34%) and low-HDL-C (+ 35%).

Conclusions
The effects on cardiovascular risk factors varied according to the types of night work and within sex groups. Some effects were observed after five years of exposure. These results support the need for early and appropriate monitoring of cardiovascular risk factors among current and former night workers.

Graphical Abstract
The moderating effect of psychological capital on the relationship between nurses’ perceived workplace bullying and emotional exhaustion: a cross-sectional study
Authors: Peng Xiao , Ma Jing , Chen Ying , Han Ying , Zhou Hong , Gong Aiping , Peng Fang , Sun Xinzhang , Wang Xingfen , Xiong Xunya , Li Li , Huang Mengting , Zeng Qingsong 
Published: January 2025

Abstract

Background
Workplace bullying (WPB) is common in nursing profession, leading to adverse effects on nurses’ health and teamwork. Although it has been suggested that psychological capital (PsyCap) could potentially moderate the relationship between WPB and emotional exhaustion, there is currently a lack of direct empirical evidence supporting this claim. Therefore, this study aims to examine how PsyCap moderates the relationship between WPB and emotional exhaustion in nurses.

Methods
A cross-sectional study was carried out involving 1068 nurses using a general information questionnaire, Negative Acts Questionnaire-Revised, Psychological Capital Questionnaire-Revision, and emotional exhaustion subscale of the Chinese version of Maslach Burnout Inventory-General Survey. The PROCESS macro was utilized to examine the moderating effect of PsyCap.

Results
WPB led to emotional exhaustion among nurses (β = 1.488, P < 0.001), and PsyCap moderated this positive relationship (β = 0.300, P < 0.001). The group with high PsyCap exhibited lower levels of emotional exhaustion. However, as the perceived WPB increased, the disparity in emotional exhaustion between the high and low PsyCap groups diminished.

Conclusions
WPB significantly contributes to nurses’ emotional exhaustion. PsyCap mitigates this impact, but this effect is limited in organizations with high WPB. it is recommended that nursing managers mitigate the detrimental impact of WPB on nurses’ emotional well-being by both strengthening nurses’ individual PsyCap and implementing comprehensive strategies to reduce WPB behaviors.
Effect of census-based correction of population figures on mortality rates in Germany
Authors: Stang Andreas , Deckert Markus 
Published: January 2025

Abstract

Background
The population figures in Germany are obtained by updating the results of the latest census with information from the statistics on birth, deaths and migration statistics. The Census 2011 in Germany corrected population figures, which have only been updated over a long period of time. The aim of this work is to show the effect of the census-based correction of the population figures on the magnitude of mortality rates in Germany 2011–2013.

Methods
We compared mortality rates (total, cancer, and cardiovascular disease) for the period 2011–2013 based on the uncorrected and Census 2011 corrected population figures. We also compared the effect of the choice of different standard populations in the age standardization of rates on the difference in uncorrected and corrected mortality rates.

Results
There is a clear decline in age-specific cancer mortality among men aged 90 and over when using the uncorrected population figures, which is reversed as soon as the corrected population figures are used. Among women, there is hardly any difference between the uncorrected and corrected mortality rates. The correction of the population figures does not lead to a qualitatively different pattern in the mortality rates for cardiovascular diseases and myocardial infarction, but it increases the magnitude of the rates, particularly for elderly men. Standard populations with higher weights at older ages produced larger corrections in mortality rates.

Conclusions
Even though the Census 2011 corrected nationwide mortality rates without age stratification differed only slightly from the uncorrected rates, there were noticeable increases in mortality, particularly in the city states of Hamburg and Berlin and in old age. Due to the particularly large error in the population figures in the older age range, an age standard that assigns lower weights at older ages should be used for age standardization of rates wherever possible.