bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐effectiveness analysis of single colonoscopy versus single fecal test for colorectal cancer diagnosis and treatment
Authors: Ishibashi Fumiaki , Suzuki Sho , Kobayashi Konomi , Tanaka Ryu , Kawakami Tomohiro , Mochida Kentaro , Nagai Mizuki , Ishibashi Yuichi , Morishita Tetsuo 
Published: February 2024

AbstractBackground and AimRegular endoscopy or fecal immunochemical test (FIT) is ideal for screening colorectal cancer. However, only a limited number of individuals undergo regular screening. This study aimed to compare the cost‐effectiveness of a single colonoscopy with a single FIT performed for colorectal cancer screening.MethodsA microsimulation model was constructed based on real‐world observational data collected from three institutions between 2019 and 2022 that compared colonoscopy‐based screening with FIT‐based screening. The total costs of diagnosis and treatment of the detected lesions using the two strategies were calculated. The incremental cost‐effectiveness ratio (ICER) per life year gained (LYG) of the colonoscopy‐based strategy was calculated.ResultsData from 11 407 patients undergoing colonoscopies and 59 176 patients undergoing FITs were used to establish a model. In the base case analysis of screening strategies, colonoscopy was more cost‐effective than FIT (ICER 415 193 yen/LYG). The ICER of the colonoscopy‐based strategy among 60‐ to 69‐year‐old patients was lowest at 394 200 yen/LYG, whereas that in 20‐ to 29‐year‐old patients was highest. Monte Carlo simulations showed that the colonoscopy‐based strategy was more cost‐effective than the FIT‐based strategy (net monetary benefit [NMB]: 5 695 957 yen vs 5 348 253 yen). When the adenoma detection rate in the colonoscopy was over 30% or the positive FIT rate was lower than 8.6% in the FIT‐based strategy, the NMB of the colonoscopy‐based strategy exceeded that of the FIT‐based strategy.ConclusionIn the microsimulation model, colonoscopy is recommended as a one‐time screening procedure in patients aged >60 years with >30% ADR or <8.6% positive FIT rate.
Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy
Authors: Tang Qingfeng , Fang Zhonghan , Liao Honglin , Zhang Yanyan , Li Chunjie , Zhou Cheng , Liu Fei , Shen Jiefei 
Published: February 2024

AbstractOrofacial neuropathic pain is a common symptom induced by orofacial nerve injury caused by a range of trauma or dental and maxillofacial procedures but lacks effective treatment. Circular RNAs (circRNAs) participate in the regulatory processes of neuropathic pain. Nevertheless, the biological roles of circRNAs in orofacial neuropathic pain remain unexplored. In this study, circRNA sequencing and Real‐time quantitative polymerase chain reaction (RT‐qPCR) were carried out. Notably, a novel circRNA named circ_lrrc49 was identified to be downregulated following chronic constriction injury of the infraorbital nerve (CCI‐ION) in mice on day 14. Subsequent RNA Antisense Purification (RAP)‐mass spectrometry and RNA immunoprecipitation found a direct interaction between circ_lrrc49 and increased sodium tolerance 1 homolog (Ist1). Western blot (WB) identified decreased expression of Ist1 on day 14 post‐CCI‐ION. Considering the known relationship between Ist1 and autophagy, LC3‐II and p62 were detected to be upregulated, and an accumulation of autophagosomes were observed at the same time point. Besides, the knockdown of circ_lrrc49 by small interfering RNA (siRNA) reduced Ist1 expression, increased LC3‐II, p62 levels and autophagosomes amount, and evoked orofacial mechanical hypersensitivity, which could be counteracted by the Ist1 overexpression. Similarly, the knockdown of Ist1 by siRNA also increased LC3‐II and p62 levels and evoked orofacial mechanical hypersensitivity without influence on circ_lrrc49. Moreover, autophagy activation by rapamycin alleviated orofacial mechanical hypersensitivity evoked by CCI‐ION or circ_lrrc49 knockdown. In conclusion, our data revealed the existence of a circ_lrrc49/Ist1/autophagy signaling axis contributing to the progression of orofacial neuropathic pain. These discoveries reveal the intricate molecular processes that drive orofacial neuropathic pain and identify circ_lrrc49 as a promising target for potential therapeutic interventions.image
A review of nonsurgical facial rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1% in periorbital revitalization
Authors: Goldberg David J. , Andriessen Anneke , Gold Michael , Lolis Margarita S. , Marchbein Shari , Nestor Mark S. , Ros Adriana 
Published: February 2024

AbstractBackgroundThe demand for nonsurgical facial rejuvenation options is growing, yet the periorbital region remains an area of relative unmet need. This review explores nonsurgical options for facial rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1%, in treating age‐related blepharoptosis as part of periorbital rejuvenation.MethodsAdvisors experienced in facial rejuvenation met to discuss existing literature on the upper face and periorbital rejuvenation and the role of oxymetazoline hydrochloride ophthalmic solution, 0.1%, in treating facial aging.ResultsAn array of nonsurgical options exist to address the signs of aging, including minimally invasive treatments, such as botulinum toxin injections and dermal fillers, and noninvasive therapy, such as lasers, chemical peels, and microdermabrasion. However, treating age‐related ptosis in periorbital rejuvenation is mainly addressed surgically. The newly approved α‐adrenergic receptor agonist oxymetazoline hydrochloride ophthalmic solution, 0.1%, provides a novel non‐interventional approach to blepharoptosis.ConclusionsFacial rejuvenation is highly sought‐after in this post‐pandemic era. Each nonsurgical treatment option has its advantages and drawbacks. A patient‐centered approach is necessary to select the appropriate procedure considering the patient's concerns and aesthetic sensibilities. The eyes are an area of primary concern for patients, yet surgery is the gold standard for treating ptosis. Oxymetazoline hydrochloride ophthalmic solution, 0.1%, is a safe and effective nonsurgical treatment for blepharoptosis.
Study on the efficacy and safety of a high‐power triple wavelength diode laser (810, 940, 1060 nm) for removing fine and less pigmented facial hair on Asian skin
Authors: Pall Anuj , Mármol Gregorio Viera 
Published: February 2024

AbstractIntroductionPerforming laser hair removal treatments on dark skin is limited by the quantity of melanin within the skin. To minimize side effects, lower values of fluence are selected when using standard 755 or 810 nm diode lasers. However, this approach may limit the effectiveness of the procedure, particularly when treating areas with thin and less pigmented hair, which is often the case in facial regions. To improve results, high‐power triple wavelength diode lasers can be used. This study aims to assess the efficacy, safety, and comfort of treatments that remove facial hair with a high‐power triple wavelength diode laser (810, 940, and 1060 nm) in static mode on Asian patients with thin and less pigmented hair.Materials and MethodsA single‐center retrospective cohort study was carried out using a high‐power triple wavelength diode laser (810, 940, and 1060 nm), with a 2.7 cm2 spot size, on faces with thin and less pigmented hair. The study comprised 23 subjects with Fitzpatrick skin types IV and V. Effectiveness was measured by counting the hairs that appeared in high‐resolution photos taken prior to and following the procedure, in addition to the Global Aesthetic Improvement Scale (GAIS). Furthermore, mathematical 3D simulations were created on the COMSOL Multiphysics® software to allow for comparisons to be made with regard to thermal damage sustained by the hair follicles and epidermal heating. Assessments were also made in relation to side effects.ResultsAn average of 66% hair reduction was observed. Patient satisfaction was between 4 and 5 points on the GAIS scale, indicating that the treatment was very well received and tolerated. Adverse side effects were not observed.ConclusionIt can be concluded that the use of a high‐power triple wavelength diode laser (810, 940, and 1060 nm) is safe and effective for the treatment of very fine and less pigmented facial hair on Asian skin. Furthermore, a triple wavelength (810, 940, and 1060 nm) laser is absorbed less by the melanin in the skin, enabling the use of higher fluences in stamping mode, with greater efficacy and safety for darker skin.
The Impact of CEO Successions Involving a Change of Gender on Strategic Change: The Moderating Role of Environmental Factors
Authors: Wu Jie , Richard Orlando C. , del Carmen Triana María , Yu Luman 
Published: February 2024

AbstractPrior research highlights the disruptive and detrimental effects of chief executive officer (CEO) successions that involve a change of gender, i.e., from a male CEO to a female CEO and vice versa. In contrast, we contend that the effects of CEO successions with gender change depend on the context in which they take place. Drawing on expectation states theory, we identify contexts in which each type of CEO succession with gender change can have positive effects on strategic change and subsequent firm performance, depending on whether the degree of gender parity in the context is sufficient for the new CEO to enact strategic changes. Consistent with our arguments, we report findings from Chinese and US samples showing that in the presence of high environmental dynamism female‐to‐male CEO succession yields greater strategic change. Conversely, when environmental dynamism is low, it is male‐to‐female CEO succession that brings about greater strategic change. Furthermore, in the Chinese context, we found that female‐to‐male CEO succession in state‐owned companies results in greater strategic change, whereas male‐to‐female CEO succession has the same effect in privately‐owned settings. Moderated mediation analysis showed that the significant interaction effects on strategic change affect long‐term downstream performance (i.e., Tobin's Q). We discuss implications for theory and practice related to CEO successions.
How the US Oath of Allegiance weakens citizenship, encodes discrimination, and muddies the moment of becoming
Authors: Feuerherm Emily , Loring Ariel 
Published: February 2024

AbstractSwearing a naturalisation oath, such as the US oath of allegiance, is the culminating step of naturalised citizenship and a moment that exposes tensions between linguistic theory and the law. Drawing on speech act theory, discourse analysis, and ethnography, this article exposes these tensions by deconstructing the language and history of the US naturalisation oath, its role in naturalisation ceremonies, and the ways it is taught in citizenship classes. This article describes the exclusionary history of the US oath and its role as a present‐day enforcer of English hegemony. We then analyse how the authoritative discourse of the naturalisation oath signals its historical significance, while also imbuing it with a level of lexical and syntactic complexity that can hamper comprehension. Throughout, we notice that policies and practitioners carry different understandings of when the exact transitory moment occurs from non‐citizen to citizen, which could be seen as undermining the illocutionary act of promising the oath. We end by offering recommendations for educators to integrate a discussion of the naturalisation oath into their citizenship class curriculum.
Origin matters? Comparing impacts of native and introduced ungulates in European protected areas
Authors: Rivas Luciano , Cassini Marcelo H. 
Published: February 2024

AbstractThe prevailing theory in invasion biology has been that introduced species have ecological and life‐history characteristics that predispose them to do more damage than native species. However, this principle has been challenged and the last decade has become involved in controversy around the hypothesis of whether origin matters. The objectives of this study were 1) to compare the intensity and types of environmental impacts of native European ungulates and their introduced counterparts using EICAT and 2) to discuss whether the results support the hypotheses on the importance of the origin of species. We relied on two previously published lists of literature on ungulate impacts. We conducted four types of comparisons: 1) same species, different locations, 2) different species, same location, 3) all species, all locations and 4) between impact mechanisms. All data comparisons between native European and introduced ungulate species indicated non‐significant differences in their levels and types of impacts. In conclusion, this study found that the negative impact of native European ungulates is like that produced by introduced species. Nevertheless, the mechanisms that determined high levels of damages in native and introduced ungulates may not be the same; thus, further research using the methodological tools provided by invasion biology is required.
Pairing relations within CO3 chondrites recovered at the Dominion Range and Miller Range, Transantarctic mountains: Constraints from chondrule olivines, noble gas, and H, C, N bulk and isotopic compositions
Authors: Righter K. , Alexander C. M. O'D. , Foustoukos D. I. , Eckart L. M. , Mertens C. A. K. , Busemann H. , Maden C. , Schutt J. , Satterwhite C. E. , Harvey R. P. , Pando K. , Karner J. 
Published: February 2024

AbstractThe Dominion Range (DOM) and Miller Range (MIL) dense collection areas (DCAs) have yielded more than 20 and 200 CO3 chondrites (carbonaceous chondrites of the Ornans chemical group), respectively, over multiple field seasons. Several samples have exhibited primitive characteristics and have been the focus of interest. With so many CO3s recovered from this area, a natural question is if there are multiple pairing groups (where pairing refers to two or more meteorites that are part of a single fall) and if there is additional primitive material that would interest the meteorite community. This comprehensive study looks at all samples using several approaches: field and macroscopic observations; magnetic susceptibility; Cr in ferroan olivine; bulk elemental and isotopic analysis of H, C, N, and noble gas analyses to determine cosmic ray exposure (CRE) ages. Magnetic susceptibilities (measured as logχ) for all samples correlate with their type II (i.e., FeO‐rich) olivine Cr contents, with the most primitive CO3s (3.00) have logχ values near 5, while the higher grade CO3s have logχ values as low as 4.17. Altogether, there appear to be two distinct CO3 pairing groups and five other unpaired CO3s recovered at the Dominion Range: (a) the main DOM 08004 pairing group (16 specimens with a CRE age of 10–16 Ma), (b) the DOM 08006 group (2 specimens incl. DOM 10847 with a CRE age of 25 Ma), (c) DOM 14359 with a CRE age of 6 Ma, (d) DOM 18070 with a CRE age of 8 Ma (these two samples have similar ages but distinct trapped 20Ne contents), (e) DOM 10900 with a CRE age of 5.5 Ma, (f) DOM 18286 (with a CRE age of ~59 Ma), and (g) DOM 19034 (with a CRE age of ~43 Ma). There are three distinct age groupings of 3.00–3.05 COs, highlighting the diverse pristine CO3 materials present in the DOM area. There is one large MIL pairing group (MIL 07099; n = 199; 9–14 Ma CRE age where measured) and one smaller pairing group with distinctly lower Cr2O3 in type II olivines (8 samples of unknown CRE age), and five unpaired or unique CO3s. Notably, the large DOM and MIL pairing groups have 9–16 Ma exposure ages that could have been delivered in a single large fall event spanning ~200 km, two separate falls that were ejection paired, or two separate falls from two separate ejections. Finally, we recommend reclassifying several CO3 to CM2 based on new data and that from previous studies.
Alternate conceptions of metaphysics
Authors: Weissman David 
Published: February 2024

AbstractMetaphysics is the inquiry having categorial form as its aim. Once all but defunct, metaphysics has now revived, though without disciplinary focus. Nine points of entry dominate current studies, each separate from and largely oblivious to the others. This essay characterizes the nine, expressing its preference for a discipline grounded in the empirical sciences while pursuing issues they ignore.
Optical and aberrometric evaluation of a new enhanced monofocal intraocular lens with isofocal optic design
Authors: Pérez‐Sanz Lidia , Charbel Carla , Poyales Francisco , Garzón Nuria 
Published: February 2024

AbstractPurposeTo evaluate the optical and aberrometric outcomes of an enhanced monofocal intraocular lens (ISOPure) compared with those of a standard monofocal lens (MicroPure) having the same platform and material.MethodsA prospective, comparative and randomised clinical study. A total of 28 eyes of 28 patients were randomly assigned to either group. Monocular visual acuity (VA) was measured at distance and intermediate under photopic and mesopic conditions. Aberrometry was analysed for 3.0‐, 4.0‐, 4.5‐ and 5.0 mm pupils. The contrast sensitivity defocus curve was measured for 3.0‐ and 4.5‐mm pupils, while the modulation transfer function (MTF) and Strehl ratio (SR) were assessed with a double‐pass system. All measurements were performed monocularly 3 months after surgery.ResultsNo significant differences were found for distance VA. Under photopic conditions, intermediate VA was better with the ISOPure lens, while no significant differences were found between the lenses under mesopic conditions. Internal and total aberrations were higher for the ISOPure lens. No significant differences were found for corneal aberrations. Additionally, both the contrast sensitivity defocus curve and optical quality showed similar behaviour for each lens, with the MTF cut‐off frequency exceeding 30 c/deg in both cases.ConclusionThe isofocal ISOPure lens enhanced intermediate VA without affecting distance VA under photopic conditions. Moreover, there were no significant differences in visual quality between the ISOPure and MicroPure lenses, despite the former exhibiting higher internal and total aberrations than the monofocal model.
Lacking family ties during COVID‐19: A longitudinal, small‐scale qualitative analysis of fictive kin in older adulthood
Authors: Van Vleet Bryce , Fuller Heather R. , Kinkade Emily E. , Huseth‐Zosel Andrea 
Published: February 2024

AbstractFamily support was an important coping mechanism for older adults during the COVID‐19 pandemic. However, not all older adults had access to traditional family ties amid the pandemic. Thus, this study sought to investigate if and how fictive kin ties were developed as a result of pandemic‐related isolation. Older adults (n = 8) who were identified as lacking access to traditional family ties were interviewed five times across 2 years of the pandemic, and their transcripts were analyzed to detect shifts in their fictive kin relationships over time. The majority (n = 5) of participants developed fictive kin ties, either before or during the pandemic, while other older adults struggled with isolation (n = 3). This research has implications that may expand the understanding of social connections and help better support older adults during moments of historical crisis.
A “test in‐train out” program versus a “go home and walk” intervention for home‐based exercise therapy in patients with peripheral artery disease: A randomized controlled trial
Authors: Manfredini Fabio , Traina Luca , Ficarra Valentina , Gandolfi Giorgio , Argentoni Antonio , Straudi Sofia , Gasbarro Vincenzo , Lamberti Nicola 
Published: February 2024

AbstractObjectiveIn this single‐blinded randomized controlled trial, we compared the “Test in‐Train Out” structured home‐based exercise program (TiTo‐SHB) with the traditional “go home and walk” exercise intervention in people with peripheral artery disease (PAD).MethodsPeripheral artery disease patients at Leriche‐Fontaine's stage II were randomized to receive TiTo‐SHB or walking advice (C‐WA). The TiTo‐SHB group performed two daily 8‐min sessions of pain‐free interval walking at progressive low‐to‐moderate speed maintained with a metronome. The C‐WA group was recommended to walk for 30 min at least three times per week and to endure claudication pain. Outcomes collected at baseline and at the end of the program (6 months) included: 6‐min and pain‐free walking distance (6MWD, PFWD), ankle‐brachial index (ABI), 5‐time sit‐to‐stand test (5STS), and health‐related quality of life (HRQoL) by the VascuQoL‐6 questionnaire.ResultsA total of 68 patients were randomized (males n = 50; aged 73 ± 9; TiTo‐SHB n = 34). At the end of the program, patients in the TiTo‐SHB group compared with the C‐WA group had significantly improved 6MWD (Δ + 60 ± 32 m vs. Δ − 5 ± 37 m; p < 0.001) and PFWD (Δ + 140 ± 92 m vs. Δ − 7 ± 87 m; p < 0.001). A significant between‐group difference in favor of the TiTo‐SHB group was also recorded for all the secondary outcomes, including 5STS (Δ − 2.6 ± 1.8 s vs. Δ + 0.8 ± 2.6 s; p < 0.001), ABI of the more impaired limb (Δ + 0.10 ± 0.11 vs. Δ + 0.02 ± 0.08; p = 0.003), and VascuQoL‐6 score (Δ +2 ± 2 vs. −1 ± 4; p < 0.001).ConclusionIn PAD patients with claudication, the pain‐free in‐home TiTo‐SHB program was more effective in improving exercise capacity and HRQoL than the traditional walking advice recommendation.
Predicting the evolution of clinical skin aging in a multi‐ethnic population: Developing causal Bayesian networks using dermatological expertise
Authors: Jouni Hussein , Jouffe Lionel , Tancrede‐Bohin Emmanuelle , André Pierre , Benamor Soraya , Cabotin Pierre‐Patrice , Chen Jin , Chen Zekai , Conceiçao Katleen , Dlova Ncoza , Figoni‐Laugel Catherine , Han Xianwei , Li Dongni , Pansé Isabelle , Pavlovic‐Ganascia Mira , Harvey Valerie , Ly Fatimata , Niverd‐Rondelé Sylvie , Khoza Nokubonga , Petit Antoine , Roux Marie‐Estelle , Shi Yu , Tardy‐Bastide Isabelle , Vashi Neelam , Wang Shanqing , Wang Youli , Wu Jun , Xu Nan , Yan Yuehua , Gomes Charles , Raynaud Edouard 
Published: February 2024

AbstractIntroductionSoftware to predict the impact of aging on physical appearance is increasingly popular. But it does not consider the complex interplay of factors that contribute to skin aging.ObjectivesTo predict the +15‐year progression of clinical signs of skin aging by developing Causal Bayesian Belief Networks (CBBNs) using expert knowledge from dermatologists.Material and methodsStructures and conditional probability distributions were elicited worldwide from dermatologists with experience of at least 15 years in aesthetics. CBBN models were built for all phototypes and for ages ranging from 18 to 65 years, focusing on wrinkles, pigmentary heterogeneity and facial ptosis. Models were also evaluated by a group of independent dermatologists ensuring the quality of prediction of the cumulative effects of extrinsic and intrinsic skin aging factors, especially the distribution of scores for clinical signs 15 years after the initial assessment.ResultsFor easiness, only models on African skins are presented in this paper. The forehead wrinkle evolution model has been detailed. Specific atlas and extrinsic factors of facial aging were used for this skin type. But the prediction method has been validated for all phototypes, and for all clinical signs of facial aging.ConclusionThis method proposes a skin aging model that predicts the aging process for each clinical sign, considering endogenous and exogenous factors. It simulates aging curves according to lifestyle. It can be used as a preventive tool and could be coupled with a generative AI algorithm to visualize aging and, potentially, other skin conditions, using appropriate images.