bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy, acceptability and satisfaction of internet-based cognitive behavioral therapy with the absence of professional guidance for depression in adults: a systematic review and meta-analysis
Authors: Li Shufeng , Gao Shuhong , Shi Xianfeng , Guo Yuchen , Xu Ting 
Published: October 2023

Abstract
Background
Depression is a high prevalence mental disorder and the global disease burden is substantial. Internet-based Cognitive Behavior Therapy (iCBT) is a means to compensate for the lack of accessibility of Cognitive Behavior Therapy (CBT) which is an effective therapeutic measure for depression. However, the characteristic of remote guidance combined with the absence of professional guidance of iCBT leads to an uncertain efficacy for depression.
Methods
We searched PubMed, Embase, The Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science from inception to May 2023. The Randomized Controlled Trials (RCTs) that iCBT with the absence of professional guidance for depression patients were selected. We assessed the risk of bias according to the Rob 2.0. Standardized mean difference (SMD), mean difference (MD) or risk ratio (RR) as well as their 95% confidence interval (CI) were calculated to evaluate the effect sizes by the software of R 5.4.1. The sources of heterogeneity were explored by subgroup analysis and meta regression.
Results
30 studies involving 10,659 participants were included. Intervention group showed a statistically significant reduction compared with control group for the posttreatment depression symptom scores (SMD: -0.54; 95% CI: -0.64 to -0.44, P < 0.01) and for the depressive symptom scores after the follow-up period (SMD: -0.38; 95% CI: -0.53 to -0.23, P < 0.01). In addition, the depressive symptom scores continued to decrease statistically significantly after the follow-up period (SMD: 0.18; 95% CI: 0.09 to 0.26, P < 0.01) compared with the scores before the follow-up period in intervention group. The drop-out rate of intervention group is higher statistically significantly (Risk Ratio: 1.51; 95% CI: 1.26 to 1.80, P < 0.01) compared with control group. The subgroup and meta regression showed that the covariate of control condition was the main source of heterogeneity to primary outcome 1 and the covariate of support content to primary outcome 3.
Conclusions
ICBT with the absence of professional guidance can relieve symptoms of depression patients and also can maintain a long-term efficacy. In addition, depression patients have a high level of satisfaction with the intervention of iCBT with the absence of professional guidance. However, the drop-out rate of intervention group is higher than control group.
Unraveling the Role of α2δ-1 in Cerebral Hemorrhage: Calcium Overload, Endoplasmic Reticulum Stress, and Microglial Apoptosis
Authors: Yu Ning , Li Xiaopeng , Wang Bingqian , Nan Chengrui , Jin Qianxu , Yang Liang , Li Depei , Zhao Zongmao 
Published: October 2023

Abstract
Background
Cerebral hemorrhage is a severe condition associated with high morbidity and mortality. Understanding the underlying pathogenesis is crucial for developing effective therapeutic strategies. This study aimed to investigate the role of the dysregulated α2δ-1 protein in cerebral hemorrhage.
Methods
Immunofluorescence and Western blot analyses were performed on cerebral hemorrhage tissue and peripheral tissue samples obtained from patients with intracerebral hemorrhage. In BV2 cells, we investigated the effects of α2δ-1-mediated calcium overload on intracellular calcium concentration, phosphorylation of PLCr and IP3R, ERS response, and BV2 microglia apoptosis.
Results
We observed a significant upregulation of α2δ-1 in cerebral hemorrhage tissue. Knockdown of α2δ-1 resulted in decreased intracellular calcium concentration and reduced phosphorylation of PLCr and IP3R in the presence of calcium. Additionally, α2δ-1-mediated calcium overload induced ERS in BV2 microglia, accompanied with increased phosphorylation of PERK and decreased ERS-related proteins levels. Furthermore, α2δ-1 knockdown significantly inhibited BV2 microglia apoptosis and downregulated apoptosis-related proteins in the presence of calcium.
Conclusions
Our study indicates the involvement of α2δ-1 in calcium-mediated signaling, endoplasmic reticulum stress, and BV2 microglia apoptosis. The findings provide a basis for considering α2δ-1 as a potential therapeutic target in neuroinflammatory and neurodegenerative conditions associated with calcium dysregulation.
Full-scale landscape metabolome map provides insights to convergent metabolite divergence and promotes edible maize breeding
Authors: Li Zhiyong , Li Chunhui , Shi Yaxing , Dong Hui , Xiao Senlin , Zhang Ruyang , Liu Hui , Jiao Yanyan , Su Aiguo , Wang Xiaqing , Zhao Yanxin , Wang Shuai , Xu Li , Fan Yanli , Luo Meijie , Xi Shengli , Yu Ainian , Wang Fengge , Ge Jianrong , Tian Hongli , Yi Hongmei , Lv Yuanda , Li Huihui , Wang Ronghuan , Lu Baishan , Song Wei , Zhao Jiuran 
Published: October 2023

Abstract
Ediblemaize is an important food crop, providing energy and nutrients to meet human health and nutritional requirements. However, how environmental pressures and human activity have shaped the ediblemaizemetabolome remains unclear.In this study, we collected 452 diverse edible maize accessions worldwide, comprising waxy, sweet and field maize. A total of 3020 non-redundant metabolites, including 802 annotated metabolites, were identified by a two-step optimized approach, which generated the most comprehensive annotated metabolites dataset in plants to date. Although specific metabolite divergencewas detected in Field-Sweet and Field-Waxy divergences, convergent metabolite divergencewas the dominant divergence pattern. We identified hub genes in all metabolite classes by mGWAS hotspot analysis. Seventeen and 16 hub genes were selected as the key divergence genes for flavonoids and lipids, respectively. Surprisingly, almost all of these genes were under non-parallel selection, which indicated non-parallel selection was the main genetic mechanism of convergent metabolic divergence. Furthermore, UGT1 and C1 in the flavonoid pathway, and KCS1 and LPP2 in the lipid pathway, played different roles in convergent metabolite divergence. Based on our research, we established the first edible maize metabolome database, EMMDB. We successfully applied EMMDB for precision improvement of nutritional and flavor traits, and an elite inbred line 6644_2 was bred with greatly improved in contents of flavonoids, lysophosphatidylcholines, lysophosphatidylethanolamines, and vitamins. These findings provide insights into the underlying genetic mechanisms of edible maize metabolite divergence and provide a database for the breeding improvement of edible maize flavor and nutritional traits by metabolome precision design.
Enhancing Child Development Through a Physically Active Learning Program to Mitigate the Impact of Physical Inactivity and ADHD Symptoms: A Crossover Trial
Authors: Simard Laurie , Bouchard Julie , Lavallière Martin , Chevrette Tommy 
Published: October 2023

Abstract

Background
A substantial number of school-aged children face developmental vulnerabilities that significantly influence their future educational paths and societal contributions. Childhood physical inactivity, particularly the failure to meet recommended activity levels, is a concern, that negatively impacts holistic child development across cognitive, physical/motor, social, affective, and language domains. Concurrently, attention deficit hyperactivity disorder (ADHD), a prevalent neurodevelopmental condition, presents concerning implications affecting all these developmental domains. Recognizing that physical activity can notably optimize the developmental trajectory of these domains, the World Health Organization underscores the need for effective physical activity interventions within school settings. Promisingly, physically active learning (PAL) programs, seamlessly blending physical activity and learning, offer potential solutions. However, their impact on holistic child development remains incompletely understood. This study sought to evaluate the effect of a PAL program on holistic child development while exploring whether a child's initial physical activity level or the presence of ADHD influenced the intervention's effectiveness.
Methods
Eighty-two children aged 9–11 years, distributed across four classes, underwent random assignment to a PAL program (Group 1) or a no-contact control condition (Group 2), with an eight-week duration for each group before switching conditions. Assessments occurred at baseline (T0), after the first condition (T1), and after the second condition (T2). The intervention's efficacy, along with relevant covariates, was analyzed through ANCOVA.
Results
The PAL program exhibited a positive association with enhanced cardiovascular fitness (VO2max) and a reduction in ADHD symptoms, notably inattention and hyperactivity-impulsivity.
Conclusions
PAL interventions hold promise as effective school-based strategies to enrich physical/motor and affective development while mitigating the adverse impact of physical inactivity and ADHD symptoms.
Hormonal Contraception and Hemoglobin Levels in Urban Malawi: A Longitudinal Analysis
Authors: Karra Mahesh , Canning David 
Published: October 2023

Abstract
Background
Studies have highlighted potential non-contraceptive benefits from women’s use of hormonal, reversible contraceptive methods. Given the physiological pathways through which hormonal contraception may interact with menstruation, a growing body of work has documented the extent to which hormonal method use might be associated with increased hemoglobin levels and reductions in the risk of anemia in women. While these findings are promising, the scope for causal inference from these studies is restricted by their cross-sectional design, which limits the extent to which bias from individual-level confounding can be mitigated.
Methods
We assess the relationship between women’s use of hormonal contraception and their risk of anemia using three years of annual woman-level panel data on 2143 women from urban Malawi controlling for individual woman fixed effects. We compare our panel results with cross-sectional estimates from the same sample.
Results
We find that hormonal method use is associated with increased levels of hemoglobin in women, though the effects are different for different hormonal methods.. Adoption of an injectable is associated with a 3.7 g/cL increase, and adoption of an implant a 5.7 g/cL increase, in hemoglobin levels. Our estimates are consistent across cross-sectional and panel model specifications, suggesting that existing cross-sectional estimates may be reliable.
Conclusions
Our findings highlight potential health benefits from hormonal contraceptive use that extend beyond pregnancy prevention. These benefits, in turn, have significant implications as to how women are counseled on contraception both within family planning and nutrition programs.
Trial Registration
This trial was registered at the American Economics Association Registry for randomized controlled trials on May 7, 2015 (AEARCTR-0000697) and at the Registry for International Development Impact Evaluations (RIDIE) on May 28, 2015 (RIDIE-STUDY-ID-556784ed86956).
Factors influencing doctors’ acceptance of artificial intelligence-enabled clinical decision support systems in tertiary hospitals in China
Authors: Yang Xiaotao , Man Dongliang , Yun Ke , zhang Shuang , Han Xiaoxu 
Published: October 2023

Abstract
Artificial intelligence-enabled clinical decision support systems (AI-CDSSs) can enhance decision-making ability to improve healthcare performance and efficiency by introducing new AI technologies such as deep neural networks and knowledge graphs. This study aimed to analyze the factors influencing doctors’ acceptance of AI-CDSSs in tertiary hospitals in China. We proposed a hypothesized model based on the unified theory of acceptance and use of technology (UTAUT) model, and developed a 25-item measurement scale. 187 doctors completed the web-survey, who’s from four tertiary hospitals in four provinces in China. We used partial least squares structural equation modeling (PLS-SEM) to analyze the data. The Cronbach α value was 0.932, the corrected item to total correlation values ranged from 0.467 to 0.744, and the average variance of extracted values ranged from 0.628 to 0.782. The standardized root mean square residual value was 0.055, the squared Euclidean distance and geodesic distance were 0.995 and 0.566, respectively. The model had explained 73.1% of doctors’ acceptance. Doctors’ acceptance of AI-CDSSs is strongly influenced by effort expectancy, is moderately influenced by trust in AI and is weakly influenced by social factors. Trust in AI as an important new factor is moderately influenced by social factors and is weakly influenced by effort expectancy and performance expectancy. Compared to the performance of decision-making, doctors are more interested in improving efficiency. Moreover, improving the ease of use, focusing on doctors' trust in AI technology, and enhancing the introduction of AI-CDSSs will encourage doctors to accept AI-CDSSs.
Body appreciation is associated with optimism/pessimism in patients with Chronic Kidney Disease: Results from a cross sectional study and validation of the Arabic version of the Optimism–Pessimism Short Scale–2
Authors: Moussa Maroun Hajj , Hachem Nay El , Sebaaly Ziad El , Moubarak Perla , Malaeb Diana , Hallit Rabih , Khatib Sami El , Hallit Souheil , Obeid Sahar , Fekih-Romdhane Feten 
Published: October 2023

Abstract
Background: Chronic Kidney Disease (CKD) patients encounter many obstacles that affect their physical and psychological well-being. The primary objective of the present study was to investigate potential correlates of optimism/pessimism in a sample of patients with CKD, including socio-demographics, body appreciation and disordered eating symptoms. As a secondary objective, we proposed to examine the psychometric properties of an Arabic translation of the Optimism–Pessimism Short Scale–2 (SOP2) before its use in our sample.
Methods: A cross-sectional study was carried out between April and May 2023, enrolling 108 participants from three hospitals in Lebanon providing insights into their sociodemographic characteristics, physical activity levels, body appreciation, optimism, pessimism, and eating attitudes.
Results: Results indicated that the Arabic-language adaptation of the SOP2 has good reliability coefficients. The two facets of the scale displayed strong correlation to each other, and highly similar correlations with external study variables (i.e., household crowding index, physical activity, body appreciation, disordered eating), suggesting that the SOP2 can be interpreted as a unidimensional measure for the psychological dispositional optimism as proposed by the developers. Furthermore, findings revealed a strong positive correlation between body appreciation and optimism, suggesting that CKD patients who appreciate their bodies tend to exhibit a more optimistic outlook on life. Conversely, higher body appreciation is associated with lower pessimism, indicating that a positive body image may mitigate feelings of hopelessness and despair in CKD patients.
Conclusion: This study contributes to the literature in two ways. First, it offers the Arabic SOP2 as a quick to complete, easy to administer, and psychometrically sound instrument that can be useful for clinical and research purposes. Second, it unveils a clear correlation between higher body appreciation and a more optimistic, less pessimistic mindset in patients with CKD.
Enhanced Antibacterial and Antibiofilm Effects of Thiolated Chitosan-Encapsulated Nisin and Selenium Nanoparticles: A Potential Nanotechnology-Based Solution for Antibiotic- Resistant Bacterial Infections
Authors: Sefidi Mozhgan Derakhshan , Bakhshi Bita 
Published: October 2023

Abstract
Nanotechnology holds significant promise in the battle against antibiotic-resistant bacteria. The aim of this study was to assess the bactericidal and antibiofilm effects of nisin and selenium encapsulated within thiolated chitosan (TC), a biodegradable and nontoxicderivative of chitosan, against common multidrug-resistant clinical enteric pathogens, including Vibrio cholerae O1 Eltor, Campylobacter jejuni, Salmonella enterica subsp. enterica, Shigella dysenteriae, Escherichia coli O157:H7, Listeria monocytogenes, andStaphylococcus aureus, using in vitro evaluations.
TC-nisin-selenium nanoparticles (TCs-N-SeNPs) were synthesized using ionic cross-linking,and their formation was confirmed through various tests. The synthesized nanoparticles were subjected to assessment of their antibacterial properties and antibiofilm activity using micro broth dilution and the crystal violet method, respectively. Furthermore, their potential inflammatory and anti-inflammatory properties were examined by measuring the release of the cytokines TNF-α, IL-6, IL-10, and TGF-β in vitro.
Nanoparticle synthesis confirmatory tests, along with the brick red color, validatedthe synthesis process and confirmedthe formation of TCs-N-SeNPs. The primary result indicates that TC-N-SeNPs exhibited a significant antibacterial and antibiofilm effect at concentrations ranging from 6.25 to 200 μg/mL. Due to disulfide linkages that keep nisin and selenium from being destroyed by lower pH, the effective release of nanosystems at alkaline pH is enhanced. The synergistic impact of uniform TCs-N-SeNPs compared to TCs-NNPs and TCs-SeNPs was evaluated successfully.
In conclusion, TCs-N-SeNPs have promising potential as an effective therapeutic approach against antibiotic-resistant bacteria, with synergistic action, improved stability and enhanced bioavailability, antibacterial and antibiofilm properties.
The patient decision aid ‘Diagnostic testing for dementia or not’: Early uptake and first impressions
Authors: Linden Iris , Heins Pascale , Wolfs Claire , Weijden Trudy van der , Dirksen Carmen , Ponds Rudolf , Perry Marieke 
Published: October 2023

Abstract

Background
The decision on diagnostic testing for dementia in general practice should be guided by patients’ preferences. To improve shared decision-making (SDM), a web-based patient decision aid (PtDA) was developed. This study aims to provide insights into the PtDA’s early uptake and first impressions after its’ online launch.
Methods
The following data were collected: (1) post-PtDA survey and semi-structured interviews with online users, (2) web metrics of the PtDA, (3) uptake numbers in selected general practices, (4) semi-structured interviews with general practitioners (GPs) and practice nurses. Early implementation outcomes (acceptability, adoption, appropriateness, and feasibility) were used to guide data collection and analysis. Quantitative data were analysed using descriptive statistics. Qualitative data were analysed using content analysis.
Results
Online users, GPs, and practice nurses were predominantly positive about the PtDA’s user-friendliness and its ability to enhance patient autonomy and preference deliberation. In the five months after its launch, 1980 users completed the PtDA. However, uptake in general practices (n = 20) was modest (45%) and online use seemed to decrease over time. The PtDA’s adoption in general practice depended on GPs’ perceived necessity of using the PtDA and/or SDM. For GPs, the PtDA’s perceived appropriateness depended on patient characteristics such as age, health status and awareness of cognitive impairment. GPs and practice nurses expressed diverse approaches to using the PtDA and barriers in time, skills, and practical issues related to its’ (early) feasibility.
Conclusions
While the PtDA’s early uptake and first impressions are generally positive, our findings highlight the need for a targeted implementation strategy for use in daily general practice in addition to the PtDA’s integration into a well-known and widely-used medical information website.
Parental Satisfaction and Acceptance of Silver Diamine Fluoride Treatment for Molar Incisor Hypomineralization in Pediatric Dentistry: A Cross-Sectional Study
Authors: Al-Nerabieah Zuhair , AlKhouli Muaaz , Dashash Mayssoon 
Published: October 2023

Abstract
The study aimed to investigate parental satisfaction and acceptance of Silver Diamine Fluoride (SDF) treatment for permanent molars affected by Molar Incisor Hypomineralization (MIH). In this cross-sectional study, a validated questionnaire employing a 5-point Likert scale was used to evaluate Aesthetics, ease of application, pain perception, and taste acceptability. Participants included 100 parents or guardians of children aged 6 to 9 years who had received SDF treatment in the past year. The findings of this study revealed high satisfaction levels (77.5%) with the treatment. Parents expressed contentment with the appearance of their child's molars after SDF application (58% agreed or strongly agreed) and found the application process easy and pain-free (100% agreed or strongly agreed). However, taste acceptability posed a challenge, with over half of the parents (53%) finding it unacceptable. Regression analysis underscored the significant impact of Aesthetics, ease of application, pain perception, and taste on parental satisfaction. Moreover, parents with higher education levels (graduate or postgraduate) exhibited higher acceptance rates compared to those with lower education levels (63.1% vs. 33.6%). Notably, parental gender and age did not significantly influence SDF treatment acceptance. This study provides critical insights into parental satisfaction and acceptance of SDF treatment for MIH-affected permanent molars. Despite concerns about tooth discoloration, the high satisfaction levels suggest that SDF holds promise as an effective treatment option. Parental education significantly influenced acceptance rates. This research highlights the importance of considering parental perspectives and tailoring communication strategies in pediatric dentistry, ultimately contributing to improved care for young patients with MIH.
Integrated Computational Biophysics approach for Drug Discovery against Nipah Virus
Authors: Palacios Georcki Ropón , Zuta Manuel Chenet , Galarza Jean Pierre Ramos , Villarreal Edinson Gervacio , Silva Jhon Pérez , Otazu Kewin , Aguila Ivonne Navarro , Wong Henry Delgado , Amay Frida Sosa , Dattani Nike , Camps Ihosvany , Patil Rajesh B. , Moin Abu Tayab 
Published: October 2023

Abstract
The Nipah virus (NiV) poses a pressing global threat to public health due to its high mortality rate, multiple modes of transmission, and lack of effective treatments. NiV glycoprotein G (NiV-G) emerges as a promising target for NiV drug discovery due to its essential role in viral entry and membrane fusion. Therefore, in this study we applied an integrated computational and biophysics approach to identify potential inhibitors of NiV-G within a curated dataset of Peruvian phytochemicals. Our virtual screening results indicated that these compounds could represent a natural source of potential NiV-G inhibitors with ∆G values ranging from -8 to -11 kcal/mol. Among them, Procyanidin B2, B3, B7, and C1 exhibited the highest binding affinities and formed the most molecular interactions with NiV-G. Molecular dynamics simulations revealed the induced-fit mechanism of NiV-G pocket interaction with these procyanidins, primarily driven by its hydrophobic nature. Non-equilibrium free energy calculations were employed to determine binding affinities, highlighting Procyanidin B3 and B2 as the ligands with the most substantial interactions. Overall, this work underscores the potential of Peruvian phytochemicals, particularly procyanidins B2, B3, B7, and C1, as lead compounds for developing anti-NiV drugs through an integrated computational biophysics approach.