bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of BTK inhibitor administered for central high-risk systemic diffuse large B cell lymphoma and primary central nervous system lymphoma: A single-center retrospective study
Authors: Zhang Litian , Li Cuicui , Yue Ningning , Jiang Haoyun , Jin Qiqi , Cao Jiajia , Wu Chongyang 
Published: January 2024

Abstract

Purpose
This study was to explore the efficacy of Bruton's tyrosine kinase inhibitor (BTKi) in treating patients with central high-risk systemic diffuse large B cell lymphoma (DLBCL) and primary central nervous system lymphoma (PCNSL), while also assessing the influence of genomic variants on treatment outcomes.
Materials and methods
The safety, efficacy, and prognosis of patients treated with BTKi-containing regimens were analyzed. Genetic variants on treatment efficacy were analyzed using whole-exome sequencing (WES).
Results
Of the 10 patients with central high-risk systemic DLBCL, nine completed treatment and were available for efficacy evaluation. The overall response rate (ORR) was 55.6%. And the 1-year central nervous system infiltration rate was 11.1% (1/9) after receiving prophylactic treatment with BTKi. In a separate group of 16 patients with PCNSL, which included three patients with relapsed PCNSL, the median overall survival (OS) was 9 (9–16) months, and six patients with primary refractory disease had a median OS of 18 (2–31) months. Besides, seven patients with PCNSL newly treated with a combination of chemotherapy and BTKi, the ORR was 100% after two courses of treatment. WES was performed on 18 patients with PCNSL, including five with R/R PCNSL who received a BTKi-containing regimen. The median PFS of 7 (3–9) months and a median OS of 16 (9–29) months.
Conclusion
The findings of this study indicate that BTKi-containing regimens are safe and effective for treating central high-risk systemic DLBCL and PCNSL.
Promoting Stress and Anxiety Recovery in Older adults: Assessing the Therapeutic Influence of Biophilic Green Walls and Outdoor view
Authors: Su Xiaoxue , Xuan Huang 
Published: January 2024

Abstract
Previous research has already provided evidence regarding the favorable impact of green walls and outdoor views on stress reduction and anxiety alleviation. However, there has been limited exploration into the combined effects of green walls and outdoor views on older adults. In this study, a between-subjects experiment was conducted using virtual reality (VR) technology with 23 participants. Following exposure to stressors, each participant underwent four randomized sessions, each lasting 5 minutes, in various virtual reality (VR) environments, encompassing non-biophilic and biophilic environments (including green walls, outdoor views, and their combination). Throughout the process, we measured physiological indicators of stress responses, including heart rate, heart rate variability, skin conductance levels, and blood pressure, using biometric sensors. Psychological changes in participants, including anxiety levels, were evaluated through the State-Trait Anxiety Inventory, recovery scales, and self-reported emotional assessments. In conclusion, in comparison to non-biophilic environments, older adults consistently exhibited lower stress levels, experienced superior anxiety relief, and demonstrated improved recovery in biophilic environments, with a notably faster recovery rate. These findings suggest that the incorporation of biophilic design principles into the indoor environments of public activity spaces within older adults care facilities can significantly contribute to stress reduction and anxiety alleviation among older adults. Furthermore, these effects appear to be contingent on the specific types of biophilic environments. These results can provide substantial evidence to support the design of indoor common activity spaces within older adults care facilities.
Genetic risk of Alzheimer’s disease is partially mediated by gut bacteria composition
Authors: Omer Mishaal , Michos Zoe , Lorincz-Comi Noah 
Published: January 2024

Abstract

Recent studies indicated that many genes which are associated with Alzheimer’s disease (AD) risk are also associated with the composition of gut microbiota, suggesting a potentially causal relationship. Other studies suggested that certain gut microbiota may lead to increased risk for neurodegeneration through their role in the microbiota-gut-brain axis. The three-way relationship between expression of AD risk genes, gut bacteria composition, and AD risk remained unclear. This study aimed to investigate the potential causal relationships between gene expression, gut bacteria, and AD. We performed multivariable Mendelian Randomization (MVMR) analyses using summary statistics from genome-wide association studies (GWAS) for Alzheimer’s disease (N = 455K), gut bacteria composition (N = 18K), and gene expression (N = 2.6K) in cortex tissue. We found evidence that at least 22 of the 36 genes may have causal effects on late-onset Alzheimer’s Disease (LOAD) risk which are at least partially mediated by gut bacteria. Alternatively, 14 genes have no evidence of effect mediation by gut bacteria. We also found evidence that levels of Acidaminococcaceae, Clostridiaceae, Lachnospiraceae, Ruminococcaceae, Verrucomicrobiaceae, and Victivallaceae may lead to a direct increase or decrease in LOAD risk. These findings may provide targets for preventative treatment and generate further studies on the mechanism of the gut-brain axis.
Flange buckling mechanism in incremental shape rolling of an automotive-type variable width component
Authors: Essa Abdelrahman , Abeyrathna Buddhika , Rolfe Bernard , Weiss Matthias 
Published: January 2024

Abstract
Automotive structural components from Advanced High Strength Steels (AHSS) can be manufactured with Flexible Roll Forming (FRF). The application of FRF in the automotive industry is limited due to flange wrinkling defects that increase with material strength. The new Incremental Shape Rolling process (ISR) has been shown to reduce wrinkling severity compared to FRF and therefore presents a promising alternative for the manufacture of high-strength automotive components. The current work analyses for the first time the mechanisms that lead to wrinkling reduction in ISR based on the critical stress conditions that develop in the flange. For this, finite element process models are validated with experimental forming trials and used to investigate the material deformation and the forming stresses that occur in FRF and ISR when forming a variable width automotive component. The results show that in ISR, the undeformed flange height decreases with increasing forming; this increases the critical buckling and wrinkling stresses with each forming pass and prevents the development of wrinkles towards the end of the forming process. In contrast, in FRF, the critical buckling or wrinkling stress is constant, while the longitudinal compressive stress in the flange increases with the number of forming passes and exceeds the critical stress. This leads to the development of severe wrinkles in the flange.
Epidural Infusion of Dexmedetomidine Improves the Experience of Primiparas Undergoing Cesarean Section with Epidural Anesthesia: A Randomized Double‑Blinded Controlled Study
Authors: Liu Minghao , Chen Xuezi , Guo Dan 
Published: January 2024

Abstract

Background Dexmedetomidine has arousal sedation and analgesic effects. This study is to investigate the effect of 0.5µg/kg epidural dexmedetomidine combined with epidural anesthesia (EA) in parturients undergoing cesarean section.Methods A total of 92 parturients were randomly divided into Group R (receiveing epidural ropivacaine alone) Group RD (receiveing epidural ropivacaine with 0.5µg/kg dexmedetomidine). The primary outcome and second outcome will be intraoperative NRS pain scores and Ramsay Sedation Scale.Results All 92 parturients were included in the analysis. The NRS were significantly lower in Group RD compared to Group R at all observation timepoint (P > 0.05). Higher Ramsay Sedation Scale was found in Group RD compared to Group R (P < 0.001). No parturient has experienced sedation score of 4 and above. No significant difference regarding the incidence of hypotension, bradycardia and nausea or vomiting, Apgar scores and the overall satisfaction with anesthesia was found between Group R and Group RD (P > 0.05).Conclusion Epidural dexmedetomidine of 0.5µg/kg added slightly extra analgesic effect to ropivacaine in EA for cesarean section. The sedation of 0.5µg/kg epidural dexmedetomidine did not cause mother-baby bonding deficit. Satisfaction with anesthesia wasn’t significantly improved by epidural dexmedetomidine of 0.5µg/kg. No additional side effect allows larger dose of epidural dexmedetomidine attempt.Trial registration: This study was registered at www.chictr.org.cn (ChiCTR2000038853)
Characterization of arcing parameters in presence of graphite powder concentration in EDM of Ti-6Al-4V
Authors: Kuthe Yadnesh Abhaykumar , Rathod Yashraj , Prajapati Anshuman , Shetiye Er. Ganesh 
Published: January 2024

Abstract
Irrespective of the toughness, strength & hardness of any conductive material, Electric Discharge Machining (EDM) is a proven machining method. Selection of most favorable process parameters for machining is desirable to avoid excessive tool wear, damaged surfaces, and unwanted roughness. For this, the main reason could be the arcing while machining. Arcing results from successive electric discharges occurring at the interface of both the electrodes. Also, presence of powder concentration makes it more susceptible to occurring. This paper emphasizes identifying the combination of parameters that lead to arcing in the machining of titanium alloy Ti-6Al-4V using copper C100 electrode on Die Sinking EDM. Graphite powder concentration of 0%, 5% and 10% in SEO-45 EDM oil is used for the investigation. To identify arcing parameters, Taguchi parameter Design approach is used. Three stage process parameters are selected for finishing, intermediate and roughing stages to study arcing. Scanning electron microscopic (SEM) images of the machined surface tells that less surface crack density (SCD) has been formed on the machined surface. Discharge current, duty cycle and graphite powder concentration are the variables and effect of arcing on Material removal rate, Electrode wear rate and Surface roughness of Ti-6Al-4V is analyzed.
A pre-implementation study on the experience of ultrasound scanning in selected healthcare facilities of Lusaka, Zambia: the perspectives of pregnant women and male partners
Authors: Hamapa Arnold , Mweetwa Mudenda , Karen Imasiku , Agripa Lungu , Desire Kabamba , Mulaya Mubambe , Shown Haluzani , Abraham Kaluba , Catherine Mkandawire , Evarist Njelesani Kizito , Peter Mwaba , David Lissauer , Caren Chizuni , Beron Nsonga , Lydia Hangulu , Hamapa Arnold 
Published: January 2024

Abstract
Preterm birth and stillbirth are the main causes of the 5 million perinatal deaths worldwide annually. The World Health Organisation recommends that every woman must have an ultrasound scan before 24 weeks gestation. Ultrasound scanning by midwives in Maternal and Child Health (MCH) during antenatal care (ANC) clinics is a new intervention in Zambia. This study sought to determine the feasibility and acceptability of the ultrasound scanning intervention in 11 healthcare facilities drawn from Chisamba, Chongwe, Mumbwa, and Lusaka districts of Zambia. This was an exploratory qualitative study that used focus group discussions with 64 pregnant women and 29 male partners accessed from the ANC clinic through snowball sampling. All data were recorded, transcribed, coded using Nvivo 12, and thematically analysed. Participants expressed their eagerness to accept and use the ultrasound scanning services that would be provided by Midwives during antenatal care in MCH departments. Ultrasound scanning by Midwives in MCH departments is a positive, feasible, and acceptable intervention for pregnant women and male partners. Participants identified a number of barriers to the feasibility and acceptability of ultrasound scanning services, including insufficient infrastructure within MCH departments to conduct ultrasound scanning, unskilled midwives to provide ultrasound scanning services, a lack of ultrasound scanners and ultrasound scanning materials, and misconceptions about the side-effects of ultrasound scanning on the fetus. To address barriers to feasibility and acceptability of USS, there is need to conduct health education on the importance of ultrasound scanning services, provide ultrasound scanners and scanning materials, train midwives in basic ultrasound scanning, and create space for ultrasound scanning services as part of MCH services to improve birth outcomes.
Attitudes, knowledge and practices concerning delirium among paediatric intensive care unit nurses: A multisite cross-sectional study in Sichuan, China
Authors: Zhang YueEr , Xie JingYing , Tang MengLin 
Published: January 2024

Abstract

Background
Delirium is an acute mental state associated with poor outcomes. The incidence of delirium is high, especially in the paediatric intensive care unit (PICU). It is important for staff, particularly nurses, to understand delirium and implement interventions to prevent it. We performed a survey with the aim of evaluating and analysing the factors influencing the knowledge, attitudes and behaviour of PICU nurses towards delirium.
Methods
This cross-sectional descriptive study included 215 PICU nurses in 6 PICUs from five Grade 3A hospitals in Sichuan Province, China. Nurses were surveyed regarding their knowledge, attitudes/beliefs, and practices related to delirium care. The data were analysed using descriptive statistics; differences between groups were compared using t tests, ANOVA and rank-sum tests. Variables with a significance level of 0.05 in the univariate analysis were entered into the multivariable regression analysis to identify predictors.
Results
Only 14.4% of the nurses had a good understanding of delirium, and 40.9% had received relevant training. The mean knowledge score was 9.01 ± 3.86, and the overall passing rate of knowledge was 49.8%. The mean attitude and behaviour scores were 40.95 ± 5.62 and 40.33 ± 8.01, respectively. Among the hospitals, different delirium assessments for children and specific training were performed, explaining approximately 10% of the variability in knowledge scores (F = 6.152), approximately 10% of the variability in attitude/belief scores (F = 5.908), and approximately 17% of the variability in practice scores (F = 10.767).
Conclusions
PICU nurses have poor knowledge of delirium, particularly regarding its clinical manifestations, influencing factors and medications used, and they have adequate attitudes and confidence and good behaviour regarding delirium in children. To better prevent delirium, we suggest that PICU departments routinely assess delirium and conduct delirium training for nurses.
Trial registration
Not applicable
Development and Validation of A Diagnostic Nomogram Based on PET/CT and Clinical Characteristics: Differentiating mediastinal lymphomas from aggressive thymic epithelial tumors
Authors: Wei Maomao , Zhou Xin , Meng XiangXi , Kong Xiangxing , He QiuJun , Cui Yan , Liu Yang , Li Nan 
Published: January 2024

Abstract
Purpose
This study aims to establish and validate diagnostic nomogram integrating the PET/CT metabolic parameter with clinical features, to differentiate between aggressive thymic epithelial tumors(aTETs) and primary mediastinal lymphomas(PMLs).
Methods
A retrospective evaluation was conducted of 376 patients with anterior mediastinal masses treated at Peking University Cancer Hospital from January 2018 to December 2022. A total of 114 patients diagnosed pathologically with aTETs or PMLs were included. Of these, 79 patients were allocated to the training set and 35 to the validation set, in a ratio of approximately 7:3. Clinical and PET/CT data were collected. Univariate analysis and multivariate logistic regression analysis were conducted to identify clinical predictive factors and create diagnostic nomogram. Receiver Operating Characteristic (ROC)curves, calibration plots, and Decision Curve Analysis (DCA) were generated. The predictive accuracy and clinical value of the model were comprehensively evaluated using the validation set.
Results
Univariate analysis and logistic regression identified three key parameters associated with differentiating aTETs from PMLs, age(OR 0.75, 95%CI 0.65~0.87,P＜0.001),location(OR 35.66, 95%CI 2.44~521.98, P=0.009), and maximum standard uptake value(SUVmax)(OR 1.30, 95%CI 1.10~1.54, P=0.002). The ROC of the nomogram for the training and validation sets were 0.981 and 0.977, respectively, demonstrating excellent predictive capability and appropriate performance. Based on DCA, the clinical prediction model shows strong clinical utility in distinguishing between aTETs and PMLs.
Conclusion
Diagnostic nomogram based on SUVmax, age and location has been established and validated, which can be used to differentiate between patients with aTETs and PMLs.
Proximal Row Carpectomy with Interposition Arthroplasty using Both Capsular Flap and Acellular Human Dermal Matrix
Authors: Lee DaeHee , Seo JoongBae , Jung JaeUk , Yoo Jaesung 
Published: January 2024

Abstract
Background
In cases of wrist arthritis, proximal row carpectomy (PRC) has been widely utilized and shown favorable long-term outcomes. However, its applicability is limited in cases where arthritis extends to the lunate fossa or capitate. Recently, surgical approaches combining various methods of interposition arthroplasty have been introduced to overcome these drawbacks. The purpose of this study was to perform PRC and interposition arthroplasty with dorsal capsule and acellular dermal matrix(ADM),and analyze the clinical outcomes of these procedures.
Methods
Thirteen cases who underwent PRC and interposition arthroplasty with ADM were retrospectively recruited. The researchers assessed the patients' Visual Analog Scale (VAS) pain score, Disabilities of the Arm, Shoulder and Hand (DASH) scores, range of motion (ROM), retear, and radiocarpal distance (RCD).
Results
One year post-surgery, both the VAS pain scores, DASH scores, and ROM showed statistically significant improvement compared to before the surgery. Upon reviewing the radiological results, the postoperative mean RCD was 4.8 ± 0.8 mm and one year follow up mean RCD was 3.6 ± 0.5 mm at one year post-surgery. Moreover, in the one year follow-up, there was no observed failure of the allodermis graft in any of the cases
Conclusion
The PRC and interposition arthroplasty with ADM demonstrated significantly improved clinical outcomes after surgery, showing a maintain of RCD without graft failure effectively.
Comparison of the Pharmacokinetics of Gadolinium-Based and Iron Oxide-Based Contrast Agents inside the Lymphatic Structure using Magnetic Resonance Lymphangiography
Authors: Chae Yeon Ji , Kim Kyung Won , Kim Mi-hyun , Woo Chul-Woong , Kim Sang-Tae , Kim Ji-wook , Shin Tae-Hyun , Lee Do-Wan , Kim Jeong Kon , Choi Yoonseok , Woo Dong-Cheol 
Published: January 2024

Abstract

Purpose: Gadolinium (Gd)-based contrast agents are mostly used for contrast-enhanced magnetic resonance lymphangiography (MRL). However, overcoming venous contamination issues remains challenging. This study aims to assess the MRL efficacy of the newly developed iron-based contrast agent (INV-001, Inventera Pharmaceuticals Inc., Seoul, Korea) which is specially designed to mitigate venous contamination issues. This study further endeavors to explore the optimal dosage, including both injection volume and concentration, required to achieve successful visualization of the popliteal lymph nodes and surrounding lymphatic vessels.
Procedures: All animals utilized in this study were male Sprague-Dawley (SD) rats weighing between 250 and 300 g. The contrast agents prepared were injected intradermally in the fourth phalanx of both hind limbs using a 30-gauge syringe in SD rats. MRL was performed every 16 min on a coronal 3D time-of-flight (TOF) sequence with saturation bands using a 9.4-T animal machine.
Results: Contrary to Gd-DOTA, which exhibited venous contamination in the majority of animals irrespective of injection dosages and conditions, INV-001 showed no venous contamination. For Gd-DOTA, the popliteal lymph nodes and lymphatic vessels reached peak enhancement 16 min after injection from the injection site and then rapidly washed out. However, with INV-001, they reached peak enhancement between 16 and 32 min after injection, with prolonged visualization of the popliteal lymph node and lymphatic vessels. INV-001 at 0.45 μmol (15 mM, 30 μL) and 0.75 μmol (15 mM, 50 μL) achieved high scores for qualitative image analysis, providing good visualization of the popliteal lymph nodes and lymphatic vessels without issues of venous contamination, interstitial space enhancement, or lymph node enlargement.
Conclusion: In MRL, INV-001, a novel T1 contrast agent based on iron, enables prolonged enhancement of popliteal lymph nodes and lymphatic vessels without venous contamination.
Correlation between trophoblast cell-surface antigen-2 (Trop-2) expression and pathological complete response in patients with HER2-positive early breast cancer treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab.
Authors: Gion María , García-Mosquera Juan José , Pérez-García José , Peg Vicente , Ruiz-Borrego Manuel , Stradella Agostina , Bermejo Begoña , Guerrero José Antonio , López-Montero Laura , Mancino Mario , Rodríguez-Morató José , Antonarelli Gabriele , Sampayo-Cordero Miguel , Llombart-Cussac Antonio , Cortés Javier 
Published: January 2024

Abstract
Purpose. The prognostic and predictive role of trophoblast cell-surface antigen-2 (Trop-2) overexpression in human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is yet unknown. We retrospectively analyzed Trop-2 expression and its correlation with clinicopathologic features and pathological complete response (pCR) in HER2-positive early breast cancer (EBC) patients treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) in the PHERGain study.
Methods. Trop-2 expression at baseline was determined in formalin-fixed, paraffin-embedded primary tumor biopsies by immunohistochemistry and was first classified into expressing (Trop-2-positive) or not-expressing (Trop-2-negative) tumors. Then, it was classified by histochemical score (H-score) according to its intensity into low (0-9), intermediate (10-49), and high (≥50). The association between clinicopathologic features, pCR, and Trop-2 expression was performed with Fisher’s exact test.
Results. Forty-one patients with tissue evaluable for Trop-2 expression were included, with 28 (68.3%) Trop-2-positive tumors. Overall, 17 (41.46%), 14 (34.15%), and 10 (24.40%) tumors were classified as low, intermediate, and high, respectively. Trop-2 expression was significantly associated with decreased pCR rates (50.0% vs. 92.3%; odds ratio [OR] 0.05; 95% CI, 0.002-0.360]; p adjusted=0.01) but was not correlated with any clinicopathologic features (p≥0.05). Tumors with the highest Trop-2 H-score were less likely to obtain a pCR (OR 0.03; 95% CI, 0.001-0.290, p adjusted<0.01). This association was confirmed in univariate and multivariate regression analyses.
Conclusion. These findings suggest a potential role of Trop-2 expression as a biomarker of resistance to neoadjuvant chemotherapy plus dual HER2 blockade and may become a strategic target for future combinations in HER2-positive EBC patients.