bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound histography in assessing the degree of pancreatic fibrosis in chronic pancreatitis
Authors: Gubergrits N. B. , Linevska K. Yu. , Gomozova E. A. , Zhdanyuk Yu. I. 
Published: December 2023

Aim: to analyze the clinical and pathogenetic significance of ultrasound histography in pancreatic fibrosis in patients with chronic pancreatitis (CP).
Materials and methods. One hundred and eighty-six patients with CP were examined. Complete blood count, urinalysis, biochemical blood and urine tests, duodenal intubation test, coproscopy, enzyme immunoassay, and radioimmune assay were performed. The levels of blood transforming growth factor β1 (TGFβ1) and fecal elastase 1 were measured. Ultrasonography and ultrasound histography of the pancreas and liver, Doppler sound study of the abdominal aorta, celiac trunk, and superior mesenteric artery were carried out.
Results. There were correlations suggesting decreased exocrine pancreatic function as its fibrosis progressed, which was indirectly reflected in the increased L index of an ultrasound histogram. The positive correlation between L index and TGFβ1 also showed increased L index in more severe pancreatic fibrosis. CP exacerbation was accompanied by decreased Kgst and N, which were confirmed by evident hyperenzymemia (the blood enzyme deviation) with the decrease of those indices. The clinical signs of CP, especially the rise in the number of dyspeptic complaints that show decreased pancreatic exocrine secretion, revealed pancreatic fibrosis. This was also shown by the fact that the debit hour of lipase and the activity of fecal elastase 1 decreased as the L index increased. There were signs that decreased blood flow in the pancreas made the fibrosis and insufficiency of the organ worse. Furthermore, ultrasound histographic findings reflected a positive correlation between pancreatic and hepatic fibrosis.
Conclusion. An examination of pancreatic ultrasound histographic correlations led to the conclusion that this technique could be used to estimate the degree of pancreatic fibrosis and CP exacerbation indirectly.
Pancreatic syphilis mimicking cancer
Authors: Gubergrits N. B. , Byelyayeva N. V. , Suprun A. A. , Kozinskaya I. A. 
Published: December 2023

Since the incidence of syphilis is increasing, the number of pancreatic lesions is expected to increase too. Pancreatic syphilis can be congenital or acquired.
The pancreas is affected in 10–80% of patients with congenital syphilis. Infection of the pancreas occurs most often during the second half of pregnancy. Morphologically, there are five types of congenital pancreatic syphilis: gummy; diffuse interstitial pancreatitis, which can be combined with multiple miliary gummas and atrophy of the pancreatic parenchyma; indurative fibrous type; with atrophy of the lobules (atrophic type); and with a predominant lesion of the pancreatic ducts —sialangitis pancreatica. In congenital syphilis, the pancreatic head is mostly affected. Early and severe damage to the islets of Langerhans is typical.
Acquired pancreatic syphilis is less common than congenital syphilis. Morphologically, it has three types: the edematous-infiltrative type, in secondary syphilis; the gummy type (pancreatitis gummosa), in tertiary syphilis; and sclerotic pancreatitis, or pancreatitis sclerotica, or “syphilitic cirrhosis of the pancreas”. The latter type is usually the outcome of the first two morphological types. Clinically acquired pancreatic syphilis proceeds according to the type of recurrent chronic pancreatitis, i.e., with periodic exacerbations (pancreatic attacks), but the pain is rarely intense, and the phenomenon of “deviation” of enzymes into the blood is rarely observed. This clinical type more often corresponds to the edematous-infiltrative morphological type of syphilitic organ damage, and less often to the gummy type. It should be noted that acquired pancreatic syphilis occurs against the background of specific damage to the liver, heart, aorta, kidneys, skin, stomach, central nervous system, etc. The differential diagnosis of gummy pancreatic lesions and pancreatic cancer is especially complicated.
Antisyphilitic treatment should be administered. Due to a toxic-allergic reaction, the symptoms of pancreatitis may exacerbate at the start of a specific therapy.
Modern capabilities of digital pancreatology
Authors: Litvin A. A. 
Published: December 2023

Personalized medicine requires the integration and analysis of vast amounts of patient data in order to provide a personalized approach. Digital pancreatology and Pancreomics facilitate personalized recommendations in the diagnosis and treatment of pancreatic diseases by analyzing data using machine learning methods to exploit the potential of this data in a similar way to Pathomics, Radiomics, and Genomics.
The aim of this article is to present a brief overview of the modern capabilities of digital medicine for the diagnosis and treatment of various pancreatic diseases.
The studies included in the review demonstrate the promising results of machine learning technologies that can both facilitate clinical prediction and decision-making and be used to interpret clinical laboratory, radiological, and endoscopic images in pancreatology and medicine in general.
Digital pancreatology and Pancreomics may be promising concepts for the analysis and prediction of the course of pancreatic diseases in the contemporary digital era.
Gut microbiota and pancreatic diseases: a microbiome-associated approach in the treatment of chronic pancreatitis
Authors: Gubergrits N. B. , Mozhyna T. L. , Byelyayeva N. V. 
Published: December 2023

Intestinal microbiota is a factor that determines human health, maintains body homeostasis, and influences the development of pancreatic diseases (acute pancreatitis, chronic pancreatitis (CP), and cancer). Butyrate, acetate, propionate, and key short-chain fatty acids, which are synthesized by probiotic bacteria, have a significant effect on the functional pancreatic activity: anti-inflammatory effect, modulation of pancreatic β-cell function, regulation of pancreatic cell mass, and strengthening of the intestinal barrier function.
It has been proven that the course of CP is associated with intestinal dysbiosis, bacterial overgrowth syndrome, a decrease in the levels of Firmicutes and Actinobacteria, and an increase in the levels of Proteobacteria phylum, Eubacterium rectale, Coprococcus, Sutterella, and Eubacterium ruminantium. Their predominance is related to exocrine pancreatic insufficiency, while Pseudomonas, Fusobacterium, and Ruminococcus gnavus are more common in CP patients without exocrine pancreatic insufficiency. Activation of pancreatic fibrogenesis is associated with an increase in Streptomyces, Turicibacter, Methylobacterium, Enterococcus, and Candidatus Paenicardiniummore.
The mechanism of action of probiotics in pancreatic diseases is associated with improved functioning of the intestinal barrier, decreased BOS and the inflammatory process, and inhibition of the signaling pathway of oncogenesis. The microbiome-associated approach to treating CP is based on the additional administration of probiotics. The multicomponent probiotic Laktiale Multi can be the drug of choice.
Features of nutrition in exocrine pancreatic insufficiency and metabolic syndrome
Authors: Hontsariuk D. O. , Hrushеlevskii M. A. 
Published: December 2023

The review presents literature data on the importance of nutritional goals, which include ensuring sufficient intake of macro- and micronutrients, reducing indigestion, the degree of malabsorption, and other risk factors in order to prevent or treat malnutrition associated with exocrine pancreatic insufficiency. Nutritional status and nutritional interventions depend on this. Attention is drawn to the indication of different nutritional options depending on the severity of the course of exocrine insufficiency and the presence of diabetes (10–15% need oral nutritional supplements, 5% — enteral nutrition through a tube, and about 1% — parenteral nutrition). The European Society for Clinical Nutrition and Metabolism (ESPEN) Guidelines for Nutritional Screening are presented. The question of the impact of chronic pancreatitis and exocrine pancreatic insufficiency on digestion with the development of maldigestion and malabsorption and the importance of these factors for the quality of life is discussed. The author reviewed in detail the metabolism of carbohydrates, proteins, and fats in enzyme pancreatic insufficiency and the importance of this knowledge in providing nutritional recommendations. The digestion of lipids in the lumen of the small intestine depends on pancreatic lipase and cofactors such as colipase and bile acids. Lipases of the stomach and salivary glands play a minor role in the digestion of triglycerides and cannot compensate for the insufficient fat digestion. There are no enzyme systems for digesting triglycerides in the brush border membrane. Therefore, lipid digestion is reduced due to insufficient secretion of lipase and a decrease in the concentration of bile acids in the lumen. Attention is paid to research methods that determine the state of fat, lean mass, muscle state, bone health, and resting energy expenditure, provide an opportunity to conduct a detailed assessment of current and usual food consumption, which promotes successful treatment.
Physicochemical properties of blood and urine in patients with alcohol-induced chronic pancreatitis against the background of obesity
Authors: Gubergrits N. B. , Byelyayeva N. V. , Severin S. S. , Severina E. O. 
Published: December 2023

In this article, the authors present the results of their studies of the physicochemical properties of blood and urine in patients with chronic alcohol-induced pancreatitis (CAP) combined with obesity.
110 patients with CAP in the acute stage against the background of obesity were examined. The ages of the examined patients ranged from 23 to 60. There were 77 (70.0%) men and 33 (30.0%) women among the patients. We also examined 30 almost healthy people aged 20 to 60 (the control group).
There are significant changes in the physicochemical properties of blood and urine in patients with CAP against the background of obesity. Indices of interfacial tensiometry and rheometry of these biological fluids correlate with other clinical, laboratory, and instrumental data in patients with CAP combined with obesity. This allows us to recommend the assessment of dynamic surface tension and rheometric indices of blood and urine for screening and an integral assessment of the functional state of the pancreas in comorbidity. In addition, it is reasonable to use the results of interfacial tensiometry and rheometry for screening the metabolic syndrome in patients with CAP against the background of obesity. In the metabolic syndrome, there is a significant increase in the surface tension 3 of the blood; in the absence of this syndrome, on the contrary, the surface tension 3 of the blood is significantly reduced.
In patients with biliary sludge and cholelithiasis, the blood viscoelasticity index (E) was significantly lower (23.18±1.07 mN/m), while without concomitant diseases of the biliary tract, the blood E was equal to 27.84±1.08 mN/m (p<0.05). Both with and without changes in the biliary system, blood E in patients with CAP against the background of obesity was significantly lower than in the control group.
The prospects of research are to study the dynamics of tensiometry and rheometry of biological fluids in CAP combined with obesity under the influence of treatment in order to study the possibility of using these indices in the integrated assessment of the effectiveness of therapy.
Miracle drugs and drug-induced liver injury: possible relationships and parallels (clinical observation of severe drug-induced damage to the liver, pancreas and kidneys)
Authors: Gubergrits N. B. , Mozhyna T. L. , Byelyayeva N. V. 
Published: December 2023

The article discusses the provisions for identifying guidelines with the identification of the association for the study of the liver (European Association for the Study of the Liver, EASL) and the American Association for the Study of Serious Liver Diseases (American Association for the Study of Liver Diseases, AASLD) for the immediate detection of drug-induced disease (DILI). Data on the etiology, exclusions, and isolation of DILI, methods of diagnosis, examination, and management of patients with DILI, both with the use of pharmacological therapy and liver transplantation, are presented.
A clinical case of multiple lesions of the liver, kidneys, and pancreas is presented against the background of long-term use of a combined drug containing acetaminophen and metamizole. The calculation of the RUCAM score confirmed that acetaminophen could be the etiological factor in chronic DILI in this case. According to the EASL recommendations, the type of DILI was determined in AASLD — a cholestatic type of lesion was stated. The presence of concomitant kidney damage in the form of chronic kidney disease, drug-induced interstitial nephritis, hepatorenal syndrome, and uremia had a great influence on the possibilities of pharmacological correction of DILI. Presumably, the long-term toxic effects of acetaminophen led to the development of pancreatic steatosis, followed by degeneration into non-alcoholic fatty pancreatic disease with the development of moderate exocrine organ insufficiency. Recommended drugs that help resolve intrahepatic cholestasis (Heptral®, Bicyclol), pancreatic (Creon®), and renal failure, the issue of prescribing corticosteroids is being resolved. A feature of this clinical case is the development of subclinical drug-induced primary biliary cholangitis (AMA-M2 were detected).
Effect of Silymarin on Gentamicin Induced Nephrotoxicity in Rats
Authors: Hilmi Syeda Rubayat , Dewan Zesmin Fauzia , Kabir AKM Nurul , Islam Muhammad Moinul , Yusuf Md Abdullah , Afreen Khandaker Nadia , Akter Mahbuba 
Published: December 2023

Background: As oxidative stress is an important factor in producing nephrotoxicity by a variety of drugs and chemicals; so, it may be assumed that agents having antioxidant property may protect the kidney from oxidative damage and can improve renal function.
Objective: In the present study the ameliorative effect of silymarin was determined in a gentamicin-induced nephrotoxic model of rat.
Methodology: This experimental animal study was carried out in the Department of Pharmacology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2014 to January 2015 for a period of one year. In this study nephrotoxicity was induced by administering gentamicin (80 mg/kg/day for 7 days) intraperitoneally. Silymarin was administered (500 mg/kg/day for 14 days) orally concomitantly with gentamicin (7 days) and sacrificed on 15th day. To determine nephrotoxicity and amelioration of nephrotoxicity as well as the status of oxidative stress and lipid peroxidation; serum creatinine, serum urea, renal cortical reduced glutathione and malondialdehyde levels were estimated. Changes in renal architecture were estimated by histopathology of renal tissues.
Results: Group (II) rats were injected gentamicin intraperitoneally for 7 days and sacrificed on 15th day showed significant (P< 0.001) increase of serum creatinine and urea level while there was significant (P< 0.001) reduction of renal cortical glutathione and increase (P< 0.001) in malondialdehyde concentration when compared to the control group (group I). This was supported by histological observations of H&E and PAS stained transverse section of renal cortex which suggested significant (P< 0.001) level of structural damage of renal cortex as evidenced from glomerular atrophy, tubular degeneration, presence of desquamated cellular debries and cast in the tubular lumen, mononuclear inflammatory cell infiltration. Statistically significant amelioration was observed in all the biochemical parameters which were supported by histology of renal cortex in silymarin treated group.
Conclusion: The results from biochemical and histological observations of the present study indicate that silymarin was probably effective to ameliorate the signs of toxic damage to the renal cortex.
Bangladesh Journal of Infectious Diseases, December 2023;10(2):71-76
Analisis Kritis atas Pengakuan Pendapatan Biaya Penyambungan Listrik (Studi Kasus : Perusahaan Listrik Indonesia)
Authors: Prihartini Ayuningtyas , Mita Aria Farah 
Published: December 2023

This study aims to look critically at the basis of changes in revenue recognition that occur in electricity connection costs in Indonesian electricity company. This case study focuses on examining the basis for the revenue recognition of electricity connection fees, where the substance of the transaction has not changed, but in terms of the accounting treatment it has undergone several changes. The research object was conducted on the Indonesian electricity company which is a single unit analysis and uses data collection techniques in the form of documentation and interviews. Data collection techniques in the form of documentation are carried out by studying public documents such as Financial Reports and Annual Reports. Meanwhile, the interview used semi-structured with open ends questions. Agency Theory is used as a basis for knowing the logic that influences decisions in preparing accounting policies. The result of the study shows that basically electricity connection is a continuous access so that revenue recognition is carried out over the time. In the prior assessment before implementation of PSAK 72, there was additional criteria which concluded that if the connection was carried out by the company as a result of regulations (laws), then this revenue could not be recognized over the time.
Pengaruh Kesadaran Wajib Pajak, Pengetahuan Perpajakan Dan Kualitas Pelayanan, Terhadap Kepatuhan Wajib Pajak Hotel (Studi Kasus Di Kabupaten Sikka, NTT)
Authors: Jaeng Theresa Yuliana , Yadnyana I Ketut 
Published: December 2023

Tax compliance is identical to the recognition of taxpayers in fulfilling their obligations in accordance with tax regulations. Hotel tax arrears are caused by low awareness of hotel taxpayers. Revenue from the hotel business has quite high potential, judging from the number of hotels and inns located in Sikka Regency. The large number of hotel tax arrears that have not been paid by taxpayers results in large hotel tax arrears at the Sikka Regency Regional Revenue Office. This study aims to analyze the effect of taxpayer awareness, tax knowledge, and service quality on hotel taxpayer compliance. Data from explanatory research with a quantitative approach. The number of samples used was 42 samples with saturated sampling method. The number of respondents in this study were 84 respondents. Data collection was done by distributing questionnaires. The data analysis technique used is path analysis using Partial Least Square 3.2.8 software. The results showed that taxpayer awareness, tax knowledge, and service quality had a positive effect on hotel taxpayer compliance. The more taxpayers are aware of their obligations have a good understanding of taxes, the higher the taxpayer compliance. In addition, the better the facilities and services provided by the tax authorities, the higher the level of taxpayer compliance. Local governments, especially the Sikka Regency Regional Revenue Agency (Bapenda), can play an active role in providing socialization about taxation that can increase the understanding of taxpayers of tax regulations so as to help increase taxpayer compliance and local tax revenue of Sikka Regency.
Pengaruh Manajemen Risiko, Intellectual Capital, Profitabilitas dan Ukuran Perusahaan Terhadap Nilai Perusahaan
Authors: Aprilia Lidiya , Wardoyo Dwi Urip 
Published: December 2023

Firm value is an investor's view of the company as seen through the stock price, the higher the stock price, it will indicate that the company has a high corporate value. That’s urgents of pharmaceuticals company to maintain company value. On the other hand, company value attracts potential investors to invest and increase public confidence in using the company's products. Finding effect of risk management, intellectual capital, profitability and company size on firm value in pharmaceutical sub-sector companies listed on the IDX Industry Classification for 2018 – 2022. This research uses quantitative methods. Data obtained from financial reports. The population used is the pharmaceutical sub-sector companies listed on the IDX Industry Classification of 12 companies. The data was processed using a purposive sampling technique. There is 9 companies for the period 2018 – 2022, so that 45 observations were obtained. The analytical method used is panel data regression analysis. Results of this study indicate that intellectual capital has a positive effect and company size has a negative effect on firm value. While risk management and profitability have no effect on firm value
Analisis Kesiapan Penggunaan Digital Finance pada UMKM di Kota Palopo Perspektif I-TOE Model
Authors: Supri Zikra , Dewintari Putri , Nadia Nadia , Risdayanti Risdayanti 
Published: December 2023

Digital finance can help improve the effectiveness and efficiency of business processes and operations, especially Micro, Small and Medium Enterprises ( SMEs ). Productive SMEs are one of the main keys in driving the acceleration of national economic recovery. The Financial Services Authority (OJK) also explained the importance of Digital finance's contribution in supporting the achievement of Sustainable Development Goals (SDGs). The urgency of the research is related to the use of digital finance which is still not massive among SMEs in Palopo City, one of which is caused by the readiness of SMEs in using digital finance. This study aims to determine the readiness of SMEs in using digital finance. The research method uses a quantitative approach based on the Individual - Technology Organization Environment (I-TOE) model by involving SMEs in Palopo City as respondents. The population is SMEs who live in Palopo city, and the sampling technique uses simple random sampling. Data collection is done through surveys / questionnaires both manually and online. The data analysis technique in this study used multiple linear regression. The results showed that partially the technology and environmental variables had a positive effect on the readiness of SMEs to use digital finance. as well as for individual and organizational variables showed results that had no effect. Meanwhile, the results of the simultaneous test can explain that the Independent variables (Environment, Organization, Individual and Technology) affect the readiness to use digital finance variable.
ANALISIS LAPORAN KEUANGAN UNTUK MENILAI KINERJA KEUANGAN PADA DINAS KEBUDAYAAN DAN PARIWISATA KABUPATEN MUSI RAWAS
Authors: Fitri Annisa , Triharyati Eri , Mulyono Hardi 
Published: December 2023

The problem examined in this study is about the Financial Performance of the Culture and Tourism Office of Musi Rawas Regency in terms of Eifficiency, Eiffectiveness and Harmony Ratios. This study uses a qualitative method. Data collection techniques used are observation, interviews and documentation. The results showed that the Financial Performance of the Culture and Tourism Office of Musi Rawas Regency in terms of Efficiency Ratio, from 2017 to 2022 can be categorized as inefficient with an aveirange efficiency ratio valuei of 93,6%. The Financial Performance of the Musi Rawas Regency Culture and Tourism Office in terms of the Effectiveness Ratio, from 2017 – 2022 as a whole is in the effective criteria with an average effectiveness ratio valuei of 94%. Thei Financial Performance of the Office of Culture and Tourism of Musi Rawas Regency in terms of the Conformity Ratio, from 2017 – 2022 can be said to be compatible, with an average compatibility ratio value of 77,3%. The results of this research are expected to be useful for the Culture and Tourism Office of Musi Rawas Regency. They need to pay more attention to things that can be a potential source of income, such as paying special attention to tourist objects.