bluuebunny/crossref_metadata_2025_split huggingface dataset:
GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome
Authors: Semino Francesca , Darche Fabrice F. , Bruehl Claus , Koenen Michael , Skladny Heyko , Katus Hugo A. , Frey Norbert , Draguhn Andreas , Schweizer Patrick A. 
Published: December 2023

AbstractLoss-of-function variants of SCN5A, encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple cardiac presentations, while underlying mechanisms are incompletely understood. Here we investigated a family with individuals affected by Brugada Syndrome (BrS) of different severity and aimed to unravel the underlying genetic and electrophysiological basis.Next-generation sequencing was used to identify the genetic variants carried by family members. The index patient, who was severely affected by arrhythmogenic BrS, carried previously uncharacterized variants of Nav1.5 (SCN5A-G1661R) and glycerol-3-phosphate dehydrogenase-1-like protein (GPD1L-A306del) in a double heterozygous conformation. Family members exclusively carrying SCN5A-G1661R showed asymptomatic Brugada ECG patterns, while another patient solely carrying GPD1L-A306del lacked any clinical phenotype.To assess functional mechanisms, Nav1.5 channels were transiently expressed in HEK-293 cells in the presence and absence of GPD1L. Whole-cell patch-clamp recordings revealed loss of sodium currents after homozygous expression of SCN5A-G1661R, and reduction of current amplitude to ~ 50% in cells transfected with equal amounts of wildtype and mutant Nav1.5. Co-expression of wildtype Nav1.5 and GPD1L showed a trend towards increased sodium current amplitudes and a hyperpolarizing shift in steady-state activation and -inactivation compared to sole SCN5A expression. Application of the GPD1L-A306del variant shifted steady-state activation to more hyperpolarized and inactivation to more depolarized potentials.In conclusion, SCN5A-G1661R produces dysfunctional channels and associates with BrS. SCN5A mediated currents are modulated by co-expression of GDP1L and this interaction is altered by mutations in both proteins. Thus, additive genetic burden may aggravate disease severity, explaining higher arrhythmogenicity in double mutation carriers.
Towards sustainable and accessible events: an exploratory research perspective
Authors: Brescia-Zapata Marta 
Published: December 2023

AbstractIn recent years, there has been a noticeable drive towards promoting sustainability at events. Nevertheless, sustainable events often overlook the topic of accessibility. In an effort to fill this gap and gather data towards possible solutions, two co-creation workshops were conducted that focussed on the practical elements of organising and coordinating an accessible and sustainable event that caters to people with diverse access needs. Through the use of practical examples taken from the work carried out as part of different EU projects, workshop participants gained insights into the logistics of creating an accessible event that is user-centric, collaborative, and sustainable. The workshops’ main aim was to settle a discussion on how to prepare guidelines and recommendations to organise a sustainable and fully accessible event. All lessons learned during the workshops were then used to organise the Green Digital Accessibility conference, which took place on 2 December 2022 in a hybrid format in Barcelona. This paper begins by outlining existing guidelines on accessibility and sustainability, before moving on to present the methodology and findings from both workshops. Subsequently, we will delve into the guidelines that were developed during the workshop. The goal of this study is to integrate universal accessibility guidelines into the ISO 20121 standard with the ultimate aim of establishing a template that ensures academic and scientific events are accessible and sustainable from their inception. This work concludes by considering some possible research avenues that combine sustainability and accessibility in event planning.
The linear stability of plane Couette flow with a compliant boundary
Authors: Walton Andrew , Yu Keming 
Published: December 2023

AbstractThe linear stability of plane Couette flow subject to one rigid boundary and one flexible boundary is considered at both finite and asymptotically large Reynolds number. The wall flexibility is modelled using a very simple Hooke-type law involving a spring constant K and is incorporated into a boundary condition on the appropriate Orr–Sommerfeld eigenvalue problem. This problem is analyzed at large Reynolds number by the method of matched asymptotic expansions and eigenrelations are derived that demonstrate the existence of neutral modes at finite spring stiffness, propagating with speeds close to that of the rigid wall and possessing wavelengths comparable to the channel width. A large critical value of K is identified at which a new short wavelength asymptotic structure comes into play that describes the entirety of the linear neutral curve. The asymptotic theories compare well with finite Reynolds number Orr–Sommerfeld calculations and demonstrate that only the tiniest amount of wall flexibility is required to destabilize the flow, with the linear neutral curve for the instability emerging as a bifurcation from infinity.
Disrupting of IGF2BP3-stabilized HK2 mRNA by MYO16-AS1 competitively binding impairs LUAD migration and invasion
Authors: Li Peiwei , Ge Haibo , Zhao Jiangfeng , Zhou Yongjia , Zhou Jie , Li Peichao , Luo Junwen , Zhang Wenhao , Tian Zhongxian , Zhao Xiaogang 
Published: December 2023

AbstractSince invasive cancer is associated with poor clinical outcomes, exploring the molecular mechanism underlying LUAD progression is crucial to improve the prognosis of patients with advanced disease. Herein, we found that MYO16-AS1 is expressed mainly in lung tissue but is notably downregulated in LUAD tissues. Overexpression of MYO16-AS1 inhibited the migration and invasion of LUAD cells. Mechanistic studies indicated that H3K27Ac modification mediated MYO16-AS1 transcription. Furthermore, we found that MYO16-AS1 competitively bound to the IGF2BP3 protein and in turn reduced IGF2BP3 protein binding to HK2 mRNA, decreasing HK2 mRNA stability and inhibiting glucose metabolism reprogramming and LUAD cell invasion in vitro and in vivo. The finding that the MYO16-AS1/IGF2BP3-mediated glucose metabolism reprogramming mechanism regulates HK2 expression provides novel insight into the process of LUAD invasion and suggests that MYO16-AS1 may be a therapeutic target for LUAD.
Low-dose exposure to malathion and radiation results in the dysregulation of multiple neuronal processes, inducing neurotoxicity and neurodegeneration in mouse
Authors: Narasimhamurthy Rekha Koravadi , Venkidesh Babu Santhi , Nayak Sangeetha , Reghunathan Dinesh , Mallya Sandeep , Sharan Krishna , Rao Bola Sadashiva Satish , Mumbrekar Kamalesh Dattaram 
Published: December 2023

AbstractNeurodegenerative disorders are a debilitating and persistent threat to the global elderly population, carrying grim outcomes. Their genesis is often multifactorial, with a history of prior exposure to xenobiotics such as pesticides, heavy metals, enviornmental pollutants, ionizing radiation etc,. A holistic molecular insight into their mechanistic induction upon single or combinatorial exposure to different toxicants is still unclear. In the present study, one-month-old C57BL/6 male mice were administered orally with malathion (50 mg/kg body wt. for 14 days) and single whole-body radiation (0.5 Gy) on the 8th day. Post-treatment, behavioural assays for exploratory behaviour, memory, and learning were performed. After sacrifice, brains were collected for histology, biochemical assays, and transcriptomic analysis. Transcriptomic analysis revealed several altered processes like synaptic transmission and plasticity, neuronal survival, proliferation, and death. Signalling pathways like MAPK, PI3K-Akt, Apelin, NF-κB, cAMP, Notch etc., and pathways related to neurodegenerative diseases were altered. Increased astrogliosis was observed in the radiation and coexposure groups, with significant neuronal cell death and a reduction in the expression of NeuN. Sholl analysis, dendritic arborization and spine density studies revealed decreased total apical neuronal path length and dendritic spine density. Reduced levels of the antioxidants GST and GSH and acetylcholinesterase enzyme activity were also detected. However, no changes were seen in exploratory behaviour or learning and memory post-treatment. Thus, explicating the molecular mechanisms behind malathion and radiation can provide novel insights into external factor-driven neurotoxicity and neurodegenerative pathogenesis.
Antler working by the last European Pleistocene hunter-gatherers of Santimamiñe cave (Northern Iberian Peninsula): technological implications of osseous equipment during the Magdalenian
Authors: Erostarbe-Tome Asier 
Published: December 2023

AbstractThis paper assesses the exploitation of osseous raw materials, namely antler, used by hunter-gatherer populations in the Late Upper Palaeolithic of Santimamiñe cave. The different categories of products (waste products, blanks, and finished objects) are analysed from a technological perspective to identify the fabrication methods employed by Magdalenian groups. A predominant operational scheme is identified, extraction by the double grooving procedure, related to the production of highly standardised rods. This study will allow us to explore possible cultural variations in the application of this procedure. It also addresses other aspects in relation to the circulation of osseous implements, the mobility of hunter-gatherer groups, and the useful life of the weapons, as regard maintenance and discard behaviour.
Hindering or Helping? User Preferences for Features of Recorded Mindfulness Training
Authors: Stanko-Kaczmarek Maja , Jankowski Tomasz , Koczyk Anna , Krzyzaniak Wadim , Meder Kalina , Dulian Kajetan 
Published: December 2023

Abstract
Objectives
Despite its numerous benefits, practicing mindfulness involves certain challenges. This study investigates the impact of various characteristics of recorded mindfulness practice instructions on recipients’ evaluations, focusing on elements that may evoke negative reactions and hinder mindfulness practice.

Method
A total of 138 participants evaluated 24 recordings of mindfulness practice excerpts. The recordings differed in terms of the speaker’s gender, the form and pace of the message, the presence of whispering, and the number of artifacts. Respondents rated each recording using a scale and provided open-ended responses about their subjective perception of the recordings. The study employed hierarchical multilevel modeling to analyze the collected data.

Results
The results indicated that recipient gender did not influence preferences for male or female-voiced recordings. However, properties such as form, pace, whispering, and artifacts did affect evaluations. Least favored instruction elements included plural pronouns, slow pacing, primarily whispered speech, and a high number of artifacts. Some differences in evaluations were observed between female and male recording conditions. Additionally, qualitative data revealed participants’ subjective reactions to recordings with varying characteristics, and the study identified the most favorable characteristics of the recordings.

Conclusions
The study results identified which qualities of recorded mindfulness instructions are least preferred and may present obstacles to initiating or continuing the practice. Therefore, this study may help create more optimal instructions and improve the design of apps and platforms offering mindfulness practice recordings, enhancing the quality and accessibility of practice for a broader audience.

Preregistration
This study is not preregistered.
The Need for a Prevention Program for Child Sexual Abuse in Brazil: A Report of Shortfall Care to Pedophilia and its Critical Consequences
Authors: Furian Gabriel , Beier Klaus Michael , Schwarz Karine , da Silva Dhiordan Cardoso , Grundmann Dorit , Lobato Maria Inês Rodrigues 
Published: December 2023

AbstractFrom a case report of a person with pedophilic disorder, this paper focuses on the issue of pedophilia, child sexual abuse, and the need for specific prevention and treatment strategies in Brazil. It seems inevitable to increase awareness for this topic within the mental health care system to protect children and reduce the risk for sexual offense in individuals at-risk. This is a case report of an individual, known by medical-psychiatric and forensic facilities for a past history of patricide, who revealed his pedophilic fantasies and behavior belatedly. To assess a pedophilic disorder and screen for other paraphilic contents, a screening questionnaire and clinical interview were used during the patient hospitalization in 2020 for a proper evaluation of sexual history and past offending behaviors. A review of the literature on pedophilia prevention programs was also carried out. WW is a middle-aged man admitted to a psychiatric unit for a severe episode of major depressive disorder and at risk of suicide. During recovery, he reported pedophilic fantasies and behaviors in his life. Sexual fantasies involving children and actual sexual offenses have remained unknown to mental health professionals and unreported to legal authorities. WW’s case alarmingly emphasizes the need for the training of health care professionals and for preventive strategies in Brazil for those who are at risk of engaging in offending sexual behaviors in a combined and intensive effort to protect children from sexual offense.
Human Enhancement Without Organizational Knowledge and by Organizational Order
Authors: Döbler Niklas Alexander , Carbon Claus-Christian , Schaub Harald 
Published: December 2023

AbstractOrganizations strive to ensure and maintain the reliability, safety, security, usability, and competitiveness of their processes, goods, and services. Improvement of employees’ skills and abilities contributes to these ends and is a relevant issue for the field of human factors. However, going a step further than designing ergonomics, implementing protocols, and conducting training is the attempt to enhance employee skills directly through various technological means. So-called Human Enhancement aims at direct technological interference with the employees’ skills and is a notoriously controversial yet deeply historical phenomenon. Drawing from empirical and theoretical literature on Human Enhancement, we seek to provide an initial analysis of this phenomenon in an organizational context. One motivational aspect of contemporary Human Enhancement is the need to meet internal, often self-related, or external, usually social or organizational, demands. Given the different effects and means of Human Enhancement, some forms are illicit, sanctioned, and/or condemned as morally wrong, while others are obligatory and well-established. Enhancement efforts can be based on individual initiative and, hence, without organizational knowledge. The opposite of the spectrum are enhancements applied by organizational order. We also emphasize how an organizational culture may incentivize engagement with illicit means of Human Enhancement. Potentially linked to safety and security-related aspects, its enhancement effects in relation to these two poles can inform stakeholders in their regulatory decisions.
Homeland Food Traditions in the Tiwanaku Colonies: Quinoa and Amaranthaceae Cultivation in the Middle Horizon (AD 600–1100) Locumba Valley, Peru
Authors: Garvin Suero Arianna , Goldstein Paul S. , d'Alpoim Guedes Jade , Sitek Matthew J. 
Published: December 2023

AbstractThe Tiwanaku civilization (around AD 500–1100) originated in the Bolivian altiplano of the south-central Andes and established agrarian colonies (AD 600–1100) in the Peruvian coastal valleys. Current dietary investigations at Tiwanaku colonial sites focus on maize, a coastal valley cultivar with ritual and political significance. Here, we examine Tiwanaku provincial foodways and ask to what degree the Tiwanaku settlers maintained their culinary and agrarian traditions as they migrated into the lower-altitude coastal valleys to farm the land. We analyze archaeobotanical remains from the Tiwanaku site of Cerro San Antonio (600 m asl) in the Locumba Valley and compare them to data from the Tiwanaku site in the altiplano and the Rio Muerto site in the Moquegua Valley during the period of state expansion. Our findings show high proportions of wild, weedy, and domesticated Amaranthaceae cultivars, suggesting that Tiwanaku colonists grew traditional high-valley (2,000–3,000 m asl) and altiplano (3,000–4,000 m asl) foods on the lowland frontier because of their established cultural dietary preferences and Amaranthaceae's ability to adapt to various agroclimatic and edaphic conditions.
WHAT DOES EGALITARIANISM REQUIRE?
Authors: Schmidtz David 
Published: December 2023

AbstractRawlsian theory notoriously claims that basic principles of justice apply to the design of a society’s basic structure. G. A. Cohen found it disturbingly convenient to treat fundamental principles as merely political rather than personal—that is, as applying exclusively to questions of institutional design and saying nothing about how to live. Instead, to Cohen, a sincere champion of egalitarian principles would, as they say, “walk the talk.”
WORKER PARTICIPATION AND THE EGALITARIAN CONCEPTION OF FAIR MARKET EXCHANGE
Authors: Christiano Thomas 
Published: December 2023

AbstractI argue for an egalitarian conception of market exchange that places the idea of equal power at the center of a procedural evaluation of markets. I explain the fundamental concept of equal power in markets and show that the egalitarian conception gives us a remedial basis for society shaping markets so that they allow a significant place for worker participation in firms. I use the phrase “worker participation” to mean that workers participate in the authoritative direction of the firm. This can include collective bargaining and worker management to introduce the kind of flexibility that is desirable in regulating market economies. Worker participation is a remedy to the presence of rigidities in markets that strongly favor authoritarian firms and that follow from and maintain unequal power in markets. The argument differs from the traditional argument that draws a parallel between state and firm, and so does not entail a general requirement of worker participation. It allows for some degree of participation of owners of capital also in the governance of firms.
THREE SOURCES OF ECONOMIC INEQUALITY
Authors: Heath Joseph 
Published: December 2023

AbstractThere are three distinct forces that conspire to produce a great deal of economic misery. We can refer to them, for convenience, as misfortune, unfairness, and improvidence. Political philosophers have often shown an interest in one or another of these, but seldom all three. Furthermore, those who do acknowledge all three have often felt driven to collapse them into one root cause of inequality. My goal in this essay will be to argue that the three are independent of one another, but more importantly, that they each require distinct remedies. This is important for egalitarians because it defeats any attempt to develop a “one-size-fits-all” policy aimed at creating a more equal society. This analysis helps us to understand several of the tensions that arise in our attempts to combat inequality that are often obscured by an overemphasis on the power of redistributive taxation as well as generalized inattention to the way that successful welfare states achieve meaningful progress in promoting greater equality.
MUST EGALITARIANS RELY ON THE STATE TO ATTAIN DISTRIBUTIVE JUSTICE?
Authors: Pourvand Kaveh 
Published: December 2023

AbstractIt is widely accepted among political philosophers that distributive justice should be promoted by the state. This essay challenges this presumption by making two key claims. First, the state is not the only possible mechanism for attaining distributive justice. We could rely alternatively on the voluntary efforts and interactions of individuals and associations in civil society. The question of what mechanism we should rely on is a comparative and empirical one. What matters is which mechanism better promotes distributive justice. We cannot settle the question a priori in favor of the state. Second, several considerations suggest a presumption in favor of relying on civil society.
Transient second-degree high-grade atrioventricular block caused by myocarditis
Authors: Özelce Bilal , Pamuk Utku , Koca Serhat , Gürsu Hazım Alper , Çetin İbrahim İlker 
Published: December 2023

AbstractMyocarditis is an inflammatory disease of the heart muscle that most commonly occurs after infectious diseases in childhood. The clinical picture of acute myocarditis ranges from asymptomatic infection to fulminant heart failure and sudden death (1). Most of the patients may present with nonspecific symptoms such as respiratory distress, chest pain, nausea, and vomiting (2). While rhythm abnormalities such as ventricular and supraventricular rhythm disorders can be observed in these patients, various degrees of atrioventricular blocks may rarely develop (3). In this article, we aimed to present a patient who developed second-degree, high-grade atrioventricular block after myocarditis and recovered completely after treatment.
Mapping the behaviour change potential of meal kits to positively influence parental food literacy
Authors: Fraser Kylie , Johnson Brittany J , Love Penelope , Spence Alison , Laws Rachel , Campbell Karen J 
Published: December 2023

Abstract

Objective:
This study aimed to examine the theoretical potential of meal kit subscription services in Australia to promote parental food literacy using the retrospective application of behaviour change frameworks.

Design:
A one-week subscription was purchased for all Australian-based meal kit subscription services (n 9) to access content and features available to subscribers. Behaviour change techniques (BCTs) identified in the subscription and meal planning features, meal kit delivery (i.e. ingredients and recipes) and website were coded using the behaviour change technique taxonomy (BCTTv1) and associated behaviour change frameworks. Identified BCTs were mapped to the theoretical domains framework to identify potential mechanisms of action for influencing parental food literacy development.

Setting:
Australia.

Results:
Thirty-five BCTs were identified across the nine meal kit services reviewed, ranging from nineteen to twenty-nine BCTs per company. Sixteen BCTs were common to all meal kits services, from the hierarchical clusters of ‘goals and planning’, ‘shaping knowledge’, ‘social support’, ‘natural consequences’, ‘comparison of behaviour’, ‘repetitions and substitution’, ‘associations’, ‘reward and threat’, ‘antecedents’ and ‘regulation’. Across the meal kit services, the most frequently identified mechanisms of action were motivation (n 27) and capability (n 19).

Conclusion:
These findings support the applicability of behaviour change frameworks to commercial meal kit subscription services and provide a theory-informed process for identifying BCTs that may be relevant for promoting parental food literacy within this context. Further research is required to explore how families engage with meal kit subscription services to determine the exposure and delivery of identified BCT content and to evaluate the potential influence on food literacy development.