bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myxopapillary Ependymoma and Fatty Filum in an Adult with Tethered Cord Syndrome: A Shared Embryological Lesion? Case Report
Authors: Adamson D Cory , Cummings Thomas J. , Friedman Allan H. 
Published: August 2005

ABSTRACTOBJECTIVE AND IMPORTANCE:Myxopapillary ependymoma and fatty fila are traditionally thought to arise via completely different pathophysiologies. Recognition of these distinct pathologies in the same patient is important for appropriate treatment and prognosis.CLINICAL PRESENTATION:A 28-year-old woman presented with low back pain, bilateral leg radiculopathies, and mild leg weakness suggestive of tethered cord syndrome. Magnetic resonance imaging revealed lesions in the area of the conus medullaris consistent with a myxopapillary ependymoma and fatty filum.INTERVENTION:Under the surveillance of intraoperative electromyographic monitoring, the patient underwent an L4–S2 laminectomy for transection of the fatty filum and gross total resection of the mass. Histopathological examination confirmed the presence of these two distinct pathologies.CONCLUSION:We report an unusual case of a myxopapillary ependymoma coexisting with a fatty filum in an adult patient. To the best of our knowledge, this association has not yet been reported. This raises the interesting question of a possible associative or causative relationship between these distinct pathologies, which have traditionally been thought to arise from different mechanisms.
Endovascular Management of Ventricular Catheter-induced Anterior Cerebral Artery False Aneurysm: Technical Case Report
Authors: Horowitz Michael , Sharts Michael , Levy Elad , Albright A Leland , Pollack Ian 
Published: August 2005

ABSTRACT

OBJECTIVE AND IMPORTANCE:
We describe the case of a 3.3-kg infant who developed an anterior cerebral artery pseudoaneurysm after ventricular catheter placement. The lesion was treated with endovascular vessel sacrifice.

CLINICAL PRESENTATION:
A 3.3-kg infant with a myelomeningocele underwent repair and ventricular catheter insertion for hydrocephalus. During shunt insertion, intracerebral arterial bleeding was encountered. Subsequent arteriography demonstrated an anterior cerebral artery pseudoaneurysm.

TECHNIQUE:
Via a transfemoral artery approach, the aneurysm and feeding vessel were catheterized with a microcatheter and wire. The aneurysm and vessel were then sacrificed with detachable platinum coils.

CONCLUSION:
Arterial injury is uncommon after ventricular catheter placement. When it does occur, however, an unstable pseudoaneurysm may form. Endovascular techniques can be used to remedy this problem, thus at times obviating the need for a standard craniotomy, which can be particularly difficult in a newborn.
Synthesis of New Green-emitting Gd2O2CO3:Tb3+ Fine Particles with High Luminescence Intensities
Authors: Masui Toshiyuki , Mayama Yuhei , Koyabu Kazuhiko , Imanaka Nobuhito 
Published: August 2005

Abstract
New green-emitting Gd2O2CO3:xTb3+ fine particles were synthesized by a flux method using the 0.476Li2CO3–0.270Na2CO3–0.254K2CO3 eutectic mixture. The emission intensity of the Gd2O2CO3:16.9 atom %Tb3+ phosphor was equivalent to that of the commercial LaPO4:Ce3+,Tb3+, in spite that the size was apparently smaller (ca. 1/10) than the commercial one.
Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA
Authors: Hahnefeld Claudia , Moll Daniela , Goette Maik , Herberg Friedrich W. 
Published: August 2005

AbstractcAMP-dependent protein kinase (PKA) forms an inactive heterotetramer of two regulatory (R; with two cAMP-binding domains A and B each) and two catalytic (C) subunits. Upon the binding of four cAMP molecules to the R dimer, the monomeric C subunits dissociate. Based on sequence analysis of cyclic nucleotide-binding domains in prokaryotes and eukaryotes and on crystal structures of cAMP-bound R subunit and cyclic nucleotide-free Epac (exchange protein directly activated by cAMP), four amino acids were identified (Leu203, Tyr229, Arg239 and Arg241) and probed for cAMP binding to the R subunits and for R/C interaction. Arg239 and Arg241 (mutated to Ala and Glu) displayed no differences in the parameters investigated. In contrast, Leu203 (mutated to Ala and Trp) and Tyr229 (mutated to Ala and Thr) exhibited up to 30-fold reduced binding affinity for the C subunit and up to 120-fold reduced binding affinity for cAMP. Tyr229Asp showed the most severe effects, with 350-fold reduced affinity for cAMP and no detectable binding to the C subunit. Based on these results and structural data in the cAMP-binding domain, a switch mechanism via a hydrophobic core region is postulated that is comparable to an activation model proposed for Epac.
Earlywood and latewood elastic properties in loblolly pine
Authors: Cramer Steven , Kretschmann David , Lakes Roderic , Schmidt Troy 
Published: August 2005

AbstractThe elastic properties of earlywood and latewood and their variability were measured in 388 specimens from six loblolly pine trees in a commercial plantation. Properties measured included longitudinal modulus of elasticity, shear modulus, specific gravity, microfibril angle and presence of compression wood. Novel testing procedures were developed to measure properties from specimens of 1 mm×1 mm×30 mm from earlywood or latewood. The elastic properties varied substantially circumferentially around a given ring and this variation was nearly as large as the variation across rings. The elastic properties varied by ring and height, but while the modulus of elasticity increased with height, the shear modulus decreased with height. A strong correlation was found between modulus of elasticity and shear modulus, but only at low heights and inner rings. Specific gravity and microfibril angle were the strongest predictors of elastic properties and explained 75% of the variation in modulus of elasticity for latewood. Despite being the best predictors in this study, these parameters accounted for less than half of the variability of earlywood modulus of elasticity, earlywood shear modulus and latewood shear modulus.
Advances in understanding bioactivity of chitosan and chitosan oligomers against selected wood-inhabiting fungi
Authors: Torr Kirk M. , Chittenden Colleen , Franich Robert A. , Kreber Bernhard 
Published: August 2005

Abstract
Nitrous acid deaminative depolymerisation was used to prepare three chitosan oligomer (CO) mixtures from high-molecular weight chitosan. These mixtures of chitosan oligosaccharides were analysed by electrospray ionisation mass spectroscopy, potentiometric titration and gel permeation chromatography. A method based on potentiometric titration of the amino groups of the oligomers gave an average degree of polymerisation (DP) for the three preparations of 5 (CODP5), 9 (CODP9) and 14 (CODP14). Chitosan acetate and the chitosan oligomer mixtures were assayed against Leptographium procerum, Sphaeropsis sapinea and Trichoderma harzianum on nutrient media. Leptographium procerum and S. sapinea growth was prevented by chitosan acetate and chitosan oligomers at concentrations of 0.3–0.4% (w/v), whereas T. harzianum was able to overcome the fungistatic action of these compounds. The oligomer preparation CODP14 exhibited superior specific activity to both CODP5 and chitosan acetate, suggesting an optimum molecular weight for bioactivity. All oligomer preparations were more effective at pH 4 than at pH 6. This result, in combination with the inactivity of N-acetylated CODP14, indicated that amino group protonation was an important factor for fungistatic activity. The CODP14 preparation was reduced with sodium borohydride and fractionated by alkali precipitation and ion exchange chromatography. Bioassays of these fractions pointed towards DP and degree of deacetylation (DD) as key factors in chito-oligosaccharide bioactivity. Conversely, the terminal aldehyde groups generated by depolymerisation did not contribute to the activity observed.
Comparison of quantitative real-time PCR, chitin and ergosterol assays for monitoring colonization of Trametes versicolor in birch wood
Authors: Eikenes Morten , Hietala Ari M. , Alfredsen Gry , Gunnar Fossdal Carl , Solheim Halvor 
Published: August 2005

AbstractThis paper describes the use of quantitative real-time PCR for monitoring colonization of birch wood (Betula pubescens) by the white-rot fungusTrametes versicolorin an EN113 decay experiment. The wood samples were harvested after 4, 8, 12, 16 and 20 weeks of incubation. The mass loss was in the range of 4–40%. Chitin and ergosterol assays were conducted for comparison. Second-order polynomial fits of the mass loss of decayed wood versus chitin, ergosterol and DNA gave correlations (r2) of 0.87, 0.61 and 0.84, respectively. Compared to the other two assays employed, real-time PCR data correlated best with the relative mass loss of decayed samples 4–8 weeks after inoculation, while the saturation and decline of DNA-based estimates for fungal colonization 16–20 weeks after inoculation indicated that the DNA assay is not suited for quantification purposes in the late stages of decay. The impact of conversion factors, extraction efficiency, inhibitory compounds and background levels in relation to the three detection assays used is discussed.
Rekursiver Entwurf stabiler Regelkreise durch sukzessive Berücksichtigung von Integratoren und quasi-statische Rückführungen (Recursive Design of Stable Control Loops by Integrator Backstepping and Quasi-static Feedback)
Authors: Rudolph Joachim 
Published: August 2005

Abstract
Die in der englischsprachigen Literatur unter der Bezeichnung integrator backstepping bekannte Methode zum Entwurf stabiler Regelkreise wird für die differentiell flachen Systeme diskutiert. Die Verwendung von Brunovsky-Zuständen und quasi-statischen Rückführungen ermöglicht eine systematische Behandlung von Systemen mit mehreren Eingangsgrößen unabhängig von der Systemdarstellung. Die Anwendung der Methode für die Trajektorienfolgeregelung wird am Beispiel eines Brückenkrans illustriert.
Infinit-dimensionale Regelung eines Brückenkranes mit schweren Ketten (Infinite-dimensional Control of a Gantry Crane with Heavy Chains)
Authors: Thull Daniel , Wild Daniel , Kugi Andreas 
Published: August 2005

Abstract
Ein flachheitsbasiertes Steuerungskonzept wird zusammen mit einem passivitätsbasierten Reglerentwurfsverfahren auf das infinit-dimensionale Modell eines Brückenkranes mit schweren Ketten angewandt. Es zeigt sich, dass mit der Position der Last ein flacher Ausgang des Systems gegeben ist, mit dessen Hilfe eine sehr elegante systematische Trajektorienplanung ermöglicht wird. Der das Trajektorienfehlersystem stabilisierende Regler wird so entworfen, dass einerseits Schwingungen der Ketten möglichst gut gedämpft werden, andererseits die gewünschte Wagenposition stabilisiert wird und darüber hinaus der Regler robust gegenüber den im realen System auftretenden Haftreibungserscheinungen ist. Diese Ziele können durch Anwenden der passivitätsbasierten Reglerentwurfstheorie in Kombination mit dem Integrator-Backstepping Entwurf auf systematische und physikalisch anschauliche Art und Weise erreicht werden. Der Beweis der asymptotischen Stabilität des geschlossenen Kreises beruht auf der Operatoren-Halbgruppentheorie und dem für infinit-dimensionale Systeme generalisierten Invarianzprinzip von LaSalle. Simulations- und Messergebnisse eines Laborexperimentes zeigen die hervorragende Güte des vorgeschlagenen Regelungskonzeptes.
Integration of data uncertainty in linear regression and process optimization
Authors: Reis Marco S. , Saraiva Pedro M. 
Published: August 2005

AbstractData uncertainties provide important information that should be taken into account along with the actual data. In fact, with the development of measurement instrumentation methods and metrology, one is very often able to rigorously specify the uncertainty associated with each measured value. The use of this piece of information, together with raw measurements, should—in principle—lead to more sound ways of performing data analysis, empirical modeling, and subsequent decision making. In this paper, we address the issues of using data uncertainty in the task of model estimation and, when it is already available, we show how the integration of measurement and actuation uncertainty can be achieved in the context of process optimization. Within the scope of the first task (model estimation), we make reference to several methods designed to take into account data uncertainties in linear multivariate regression (multivariate least squares, maximum likelihood principal component regression), and others whose potential to deal with noisy data is well known (partial least squares, principal component regression, and ridge regression), as well as modifications of previous methods that we developed, and compare their performance. MLPCR2 tends to achieve better predictive performance than all the other tested methods. The potential benefits of including measurement and actuation uncertainties in process optimization are also illustrated. © 2005 American Institute of Chemical Engineers AIChE J, 2005
Study on shrinkage characteristics of heated falling liquid films
Authors: Zhang Feng , Zhang Zhibing , Geng Jiao 
Published: August 2005

AbstractA liquid film flowing down along a heated solid surface may be substantially influenced by the Marangoni effect, which arises from the existence of a surface tension gradient that is induced by the variations of surface temperature in the transverse direction of the film, causing appreciable contraction of the film. In this work, the governing equations for laminar falling liquid films over a heated plate with constant surface temperature were solved and the surface temperature profile of the film was obtained. By considering the surface tension gradient and shrinkage characteristics in the brim of the heated film, a shrinkage model that gives the film interfacial area was derived based on the experimental infrared images. A comparison of the model with experimental data shows that the model can satisfactorily describe the flow characteristics of falling heated films. The model is expected to be useful for the design and operation of falling film equipments. © 2005 American Institute of Chemical Engineers AIChE J, 2005
Noninactivation of a portion of Xq28 in a balanced X‐autosome translocation
Authors: Du Sart Desirée , Kalitsis Paul , Schmidt Malgorzata 
Published: August 2005

AbstractWe present a balanced translocation (X;9) (q28;q21) in which the normal X chromosome is preferentially active. The derivative X chromosome is inactive in 93% of fibroblasts, but the X portion translocated onto chromosome 9 is not inactivated, as apparent from DNA methylation and chromosome replication patterns. Consequently, the patient is functionally disomic for the part of Xq28 distal to the locus LICAM.
Study of color vision in fragile X syndrome
Authors: Finucane Brenda M. , Jaeger Edward , Dunn Eric , Scott Charles I. 
Published: August 2005

AbstractVarious theories have been postulated to account for the unusual inheritance pattern observed in the fragile X syndrome. The recent finding of a secondary amplification of the fragile X mutation in the offspring of carrier females [Oberle et al., 1991; Yu et al., 1991] is consistent with a maternal imprinting process. Laird [1987] has proposed that the fragile X mutation blocks complete reactivation of a previously inactivated fragile X chromosome. We have tested whether or not such a localized block extends as far distal as the red/green color‐vision complex at Xq28. We found no evidence of color‐vision defects among 25 male subjects with the fragile X syndrome. A fragile X positive woman also had normal color vision, despite being an obligate carrier of her father's gene for red/green color blindness. We conclude that the fragile X gene does not affect the function of neighboring colorvision genes, nor does it affect their ability to compensate adequately for inherited color deficiency on the homologous X chromosome in females.
Prevalence of nonclassical congenital adrenal hyperplasia among women self‐referred for electrolytic treatment of hirsutism
Authors: Killeen Anthony A. , Hanson Naomi Q. , Eklund Rachel , Cairl Christina J. , Eckfeldt John H. 
Published: August 2005

AbstractNonclassical congenital adrenal hyperplasia (NCCAH) is well recognized among women who seek medical attention for hirsutism. However, the prevalence of this disorder among women self‐referred for electrolytic treatment of hirsutism is unknown. We hypothesized that the prevalence of NCCAH among women attending an electrolysis clinic might be high. By measuring the morning salivary 17‐hydroxyprogesterone (17‐OHP) as a screening test for NCCAH in 46 women in the follicular phase of their menstrual cycle, we identified 12 subjects with a high basal salivary 17‐OHP. Eleven agreed to have a 60‐minute Cosyntropin‐stimulation test, as did an additional 6 of 9 women with normal basal salivary 17‐OHP, but with a particularly high hirsutism score. One of the women with high basal salivary 17‐OHP had a 60‐minute Cosyntropin response, which was diagnostic of NCCAH. She was of the Ashkenazi Jewish decent, a group previously reported to have a high prevalence of NCCAH. A second woman with high salivary 17‐OHP had a Cosyntropin‐stimulation response consistent with heterozygosity for 21‐hydroxylase deficiency. None of the Cosyntropin‐stimulation responses in those chosen for a high hirsutism score were diagnostic. Thus, 1 of 46 (2.2%) of the women who entered our study had unrecognized NCCAH, a prevalence only about 2‐fold greater than that reported in the general population. Therefore, we recommend that electrolysis clinics advise clients from ethnic groups known to have a high frequency of NCCAH of the advisability of having a formal medical evaluation for NCCAH.
Survival of children with Down syndrome in Italy
Authors: Mastroiacovo Pierpaolo , Bertollini Roberto , Corchia Carlo 
Published: August 2005

AbstractA cohort of 917 Down syndrome (DS) children born in Italy between 1978 and 1984 was studied for survival through the age of 8 years. The highest mortality occurred in the first month of life (7.9%); survival was about 80% at 1 year, 78% at 2 years, and 76% at 5 years, with small decreases thereafter. At the univariate analysis, survival was lower for subjects with congenital heart disease (CHD), birth weight <2,500 g, parity of 3 or plus, maternal age ≥35 years, and for those born in Southern Italy compared with Northern Italy. No differences in survival were observed by sex and by socioeconomic status. The Cox proportional hazard model was used to evaluate the effect of each variable adjusted for all the others present in the model. Presence of CHD (odds ratio = 3.27; 95% confidence interval (C.I.) 2.31–4.63), birth in the South (odds ratio = 2.69; 95% C.I. 1.91–3.79), and low birth weight (odds ratio = 1.87; 95% C.I. 1.29–2.72) were independently associated with survival. None of the other variables emerged as a statistically significant prognostic factor. Various hypotheses were considered to interpret the unexpected effect of place of birth on survival. Quality of medical care provided in the South of Italy is the most likely determinant of the high mortality observed among children with DS born in that area of Italy. Such differences in survival within the same country could occur in other developed nations as well.
Embryonic testicular regression sequence: A part of the clinical spectrum of 46, XY gonadal dysgenesis
Authors: Marcantonio Sandra M. , Fechner Patricia Y. , Migeon Claude J. , Perlman Elizabeth J. , Berkovitz Gary D. 
Published: August 2005

AbstractWe report on a group of 9 subjects who had a 46, XY karyotype, ambiguous genitalia, abnormalities of sexual duct formation, and lack of gonadal tissue on one or both sides. This is sometimes referred to as “embryonic testicular regression.” Previous investigators have suggested that this condition results from loss of testes at a critical stage in development. We examined the possibility that the “embryonic testicular regression” is part of the clinical spectrum of 46, XY gonadal dysgenesis.Four subjects totally lacked gonadal tissue, three of them having ambiguous genitalia, and one a micropenis. The development of incongruous sexual ducts (presence of Müllerian ducts in the subject with micropenis, and absence of Müllerian and Wolffian ducts in two subjects with ambiguous genitalia) suggests that the embryonic gonads were intrinsically functionally abnormal before their disappearance.Five subjects had unilateral gonadal tissue, ambiguous genitalia, and a mix of Wolffian and Müllerian structures. The development of incongruous sexual ducts in 3 of them, the presence of ambiguous external genitalia in 5, and the presence of abnormal gonadal histology in 2 patients all indicate an underlying abnormality of gonadal differentiation in these subjects.The occurrence of testicular regression in several subjects in the family of one patient suggests a genetic basis for the condition. The presence of multiple congenital anomalies in other subjects in our study suggests either a mutation in a single gene that functions in several developmental pathways, or a defect of multiple genes that might be the result of a chromosome deletion. The sex‐determining region Y (SRY) gene was sequenced in five subjects and was normal in all of them, suggesting that the underlying genetic abnormality in these subjects is located in one of several genes that function subsequent to SRY in the early stages of testis differentiation. © 1994 Wiley‐Liss, Inc.
Patterns in multimalformed babies and the question of the relationship between sirenomelia and VACTERL
Authors: Schüler Lavínia , Salzano Francisco M. 
Published: August 2005

AbstractStarting from a data base of over one million births investigated in 11 countries as a part of the Latin American Study of Congenital Malformations, 1,428 babies with three or more malformations without known pathogenesis or cause were studied. The objective was to search for statistically significant associations between defects and the delineation of new syndromes. One hundred and twentyone patients presented an association between malformations of the digestive and urogenital systems involving mainly anal, renal, and genital anomalies, while 21 of them had 3 or more VACTERL defects. The frequencies of these defects were intermediate between those observed for VACTERL or sirenomelia, supporting the idea that these conditions have a similar pathogenesis. Statistical approaches like this one may be helpful in identifying processes and biological entities that may be missed using simple clinical observations. © 1994 Wiley‐Liss, Inc.
Dynamic mosaicism involving an unstable supernumerary der(22) chromosome in cat eye syndrome
Authors: Urioste Miguel , Visedo Guillermo , Sanchís Amparo , Sentís Carlos , Villa Amelia , Ludeña Paloma , Hortigüela José L. , Martínez‐Frías María Lusia , Fernández‐Piqueras José 
Published: August 2005

AbstractWe have studied a girl, her sister and her mother who had a supernumerary marker chromosome in mosaicism. The marker was studied by cytogenetic methods and nonisotopic in situ hybridization with the single D22S9 DNA probe which maps to 22q11. The supernumerary chromosome was derived from a chromosome 22 and it did not present the same morphology in all the cells. At least 5 distinct types of the marker chromosome were detected and some of them were probably derived from each other (dynamic mosaicism).The proposita had an MCA pattern consistent with mild cat eye syndrome, while her sister and her mother had some of the manifestations described in this syndrome. A specific corelation could be established between phenotype and karyotype. © 1994 Wiley‐Liss, Inc.