bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with chronic cluster headache may show reduced activity energy expenditure on ambulatory wrist actigraphy recordings during daytime attacks
Authors: Vandenbussche Nicolas , Van Der Donckt Jonas , Brouwer Mathias De , Steenwinckel Bram , Stojchevska Marija , Ongenae Femke , Hoecke Sofie Van , Paemeleire Koen 
Published: October 2023

Structured AbstractObjectiveTo investigate the changes in activity energy expenditure throughout daytime cluster headache attacks in patients with chronic cluster headache, and to evaluate the usefulness of actigraphy as a digital biomarker of cluster headache attacks.BackgroundCluster headache is a primary headache disorder characterized by attacks of severe to very severe unilateral head pain with ipsilateral cranial autonomic symptoms and/or a sense of restlessness or agitation. We hypothesized increased activity energy expenditure from hyperactivity during attacks measured by actigraphy.MethodsAn observational study including patients with chronic cluster headache was conducted. During 21 days, patients wore an actigraphy device on the non-dominant wrist and recorded cluster headache attack-related data in a dedicated smartphone application. Accelerometer data was used for the calculation of activity energy expenditure before and during daytime cluster headache attacks that occurred in ambulatory settings, and without restrictions on acute and preventive headache treatment. We compared the activity and movements during the pre-ictal, ictal, and postictal phases with data from wrist-worn actigraphy with time-concordant intervals during non-headache periods.ResultsFour patients provided 34 attacks, of which 15 attacks met the eligibility criteria for further analysis. In contrast with the initial hypothesis of increased energy expenditure during cluster headache attacks, a decrease in movement was observed during the pre-ictal phase (30 min before onset to onset) and during the headache phase. A significant decrease (p<0.01) in the proportion of high-intensity movement during headache attacks, of which the majority were oxygen-treated, was observed. This trend was less present for low-intensity movements.ConclusionThe results of our analysis may shift the initial hypothesis for future research towards a decrease in activity energy expenditure during the pre-ictal and headache phase of daytime attacks in patients with chronic cluster headache under acute and preventive treatment in ambulatory settings.
A mixed method study to assess behavioral and social predictors of parent/caregiver’s intention to vaccinate their children against COVID-19 disease in an Indian state marked by significant health disparities
Authors: Singh Tulika , Kumar Sanjay , Sinha Setu , Singh Varsha 
Published: October 2023

AbstractBackgroundParents/caregivers are the key decision-makers for child’s health care including vaccination. Vaccine hesitancy along with lagging full immunization coverage for childhood vaccination in India, affect child health outcome and will affect covid-19 vaccine uptake in children. It is important to understand behavioral and social factors surrounding childhood COVID-19 vaccination to design appropriate interventions to improve uptake.MethodsA mixed-method approach combining quantitative and qualitative method was undertaken. A cross sectional survey of parents/caregivers of children aged less than 18 years residing in the state was carried out to find the prevalence and predictors of parent/ caregiver’s intention to vaccinate against COVID-19 disease. Semi-structured interviews were carried out to find facilitating and barrier factors for childhood COVID-19 vaccination.ResultOut of 9904 study participants, 73.4% had intention to vaccinate. Parent/caregiver’s education and occupation, marital status, family type, family income, co-morbidity and previous COVID-19 infection in family, childhood vaccination under NIS, were found to be significantly associated. The likelihood of intention to vaccinate children against COVID-19 disease was greater among parents/caregivers aged 18-29 years (OR=2.631, 95% CI [1.733- 3.995], illiterate parents/caregivers (OR=3.037, 95% CI [2.319-3.977], prior COVID-19 infection in family (OR=1.595, 95% CI [1.432-1.821], and children’s prior vaccinations under NIS (OR=1.251, 95% CI [1.218-1.289]. In qualitative part, forty-five semi-structured interviews were conducted. The majority of intending parents gave vaccine effectiveness, increased immunity, high infection risk, herd immunity, and medical recommendations as reasons. Parents who refused mentioned inadequate data, adverse effects, beliefs, safety, and inconvenience as reasons. Effectiveness, and safety, long-term effects, and the short testing period were among the concerns of hesitant parents.ConclusionIn order to promote COVID-19 vaccination among children, we need to address barriers, facilitators and behavioral determinants of parents/caregivers identified in this study and have targeted strategies for them.
Exome copy number variant detection, analysis and classification in a large cohort of families with undiagnosed rare genetic disease
Authors: Lemire Gabrielle , Sanchis-Juan Alba , Russell Kathryn , Baxter Samantha , Chao Katherine R. , Singer-Berk Moriel , Groopman Emily , Wong Isaac , England Eleina , Goodrich Julia , Pais Lynn , Austin-Tse Christina , DiTroia Stephanie , O’Heir Emily , Ganesh Vijay S. , Wojcik Monica H. , Evangelista Emily , Snow Hana , Osei-Owusu Ikeoluwa , Fu Jack , Singh Mugdha , Mostovoy Yulia , Huang Steve , Garimella Kiran , Kirkham Samantha L. , Neil Jennifer E. , Shao Diane D. , Walsh Christopher A. , Argili Emanuela , Le Carolyn , Sherr Elliott H. , Gleeson Joseph , Shril Shirlee , Schneider Ronen , Hildebrandt Friedhelm , Sankaran Vijay G. , Madden Jill A. , Genetti Casie A. , Beggs Alan H. , Agrawal Pankaj B. , Bujakowska Kinga M. , Place Emily , Pierce Eric A. , Donkervoort Sandra , Bönnemann Carsten G. , Gallacher Lyndon , Stark Zornitza , Tan Tiong , White Susan M. , Töpf Ana , Straub Volker , Fleming Mark D. , Pollak Martin R. , Õunap Katrin , Pajusalu Sander , Donald Kirsten A. , Bruwer Zandre , Ravenscroft Gianina , Laing Nigel G. , MacArthur Daniel G. , Rehm Heidi L. , Talkowski Michael E. , Brand Harrison , O’Donnell-Luria Anne 
Published: October 2023

AbstractCopy number variants (CNVs) are significant contributors to the pathogenicity of rare genetic diseases and with new innovative methods can now reliably be identified from exome sequencing. Challenges still remain in accurate classification of CNV pathogenicity. CNV calling using GATK-gCNV was performed on exomes from a cohort of 6,633 families (15,759 individuals) with heterogeneous phenotypes and variable prior genetic testing collected at the Broad Institute Center for Mendelian Genomics of the GREGoR consortium. Each family’s CNV data was analyzed using theseqrplatform and candidate CNVs classified using the 2020 ACMG/ClinGen CNV interpretation standards. We developed additional evidence criteria to address situations not covered by the current standards. The addition of CNV calling to exome analysis identified causal CNVs for 173 families (2.6%). The estimated sizes of CNVs ranged from 293 bp to 80 Mb with estimates that 44% would not have been detected by standard chromosomal microarrays. The causal CNVs consisted of 141 deletions, 15 duplications, 4 suspected complex structural variants (SVs), 3 insertions and 10 complex SVs, the latter two groups being identified by orthogonal validation methods. We interpreted 153 CNVs as likely pathogenic/pathogenic and 20 CNVs as high interest variants of uncertain significance. Calling CNVs from existing exome data increases the diagnostic yield for individuals undiagnosed after standard testing approaches, providing a higher resolution alternative to arrays at a fraction of the cost of genome sequencing. Our improvements to the classification approach advances the systematic framework to assess the pathogenicity of CNVs.
Structural and molecular basis of choline uptake into the brain by FLVCR2
Authors: Cater Rosemary J. , Mukherjee Dibyanti , Iturbe Eva Gil , Erramilli Satchal K. , Chen Ting , Koo Katie , Grez Nicolás Santander , Reckers Andrew , Kloss Brian , Gawda Tomasz , Choy Brendon C. , Zheng Zhening , Clarke Oliver B. , Yee Sook Wah , Kossiakoff Anthony A. , Quick Matthias , Arnold Thomas , Mancia Filippo 
Published: October 2023

AbstractCholine is an essential nutrient that the human body needs in vast quantities for cell membrane synthesis, epigenetic modification, and neurotransmission. The brain has a particularly high demand for choline, but how it enters the brain has eluded the field for over fifty years. The MFS transporter FLVCR1 was recently determined to be a choline transporter, and while this protein is not highly expressed at the blood-brain barrier (BBB), its relative FLVCR2 is. Previous studies have shown that mutations in humanFlvcr2cause cerebral vascular abnormalities, hydrocephalus, and embryonic lethality, but the physiological role of FLVCR2 is unknown. Here, we demonstrate bothin vivoandin vitrothat FLVCR2 is a BBB choline transporter and is responsible for the majority of choline uptake into the brain. We also determine the structures of choline-bound FLVCR2 in the inward- and outward-facing states using cryo-electron microscopy to 2.49 and 2.77 Å resolution, respectively. These results reveal how the brain obtains choline and provide molecular-level insights into how FLVCR2 binds choline in an aromatic cage and mediates its uptake. Our work could provide a novel framework for the targeted delivery of neurotherapeutics into the brain.
On the diffusion and implementation of trust-based management in Scandinavia: cross-country survey evidence
Authors: Siverbo Sven , Johansson-Berg Tobias , Øllgaard Bentzen Tina , Winsvold Marte 
Published: October 2023

PurposeThis study aims to examine the diffusion and implementation of trust-based management (TBM) in Scandinavian countries (Denmark, Norway and Sweden). TBM is a novel “anti-New Public Management (NPM)” innovation within the realm of New Public Governance (NPG), which asserts that leadership and control in public sector organizations should be practiced and designed based on the assumption that civil servants and employees in general are trustworthy. The research questions are as follows: How has TBM been diffused and implemented in Scandinavia? To what extent can the institutional logics framework increase understanding of similarities and differences between the Scandinavian countries (Denmark, Norway and Sweden)?Design/methodology/approachThe authors designed and submitted surveys to the municipal directors of the three Scandinavian municipal populations, thereby producing a unique cross-country dataset on TBM diffusion and implementation in Scandinavia (Denmark, Norway and Sweden).FindingsThe authors' study shows that TBM has diffused widely among Scandinavian municipalities and has developed into a municipal-level concept across policy fields and sectors. While Denmark stands out as an earlier and more decisive TBM reformer, the results show that similarities in the diffusion and implementation of TBM in Scandinavian countries are more apparent than the differences.Originality/valueThis study contributes to the public management literature and research on anti-NPM and NPG concepts by being the first wide-scale empirical study of TBM diffusion and implementation in the Scandinavian municipal sectors.
Modelling the inhibitors of integrated sustainable lean manufacturing system in the South Indian SMEs using fuzzy logic
Authors: Gopi Vivek , P.G. Saleeshya 
Published: October 2023

Purpose
Small and medium-scale enterprises (SMEs) that operate with modest financial investments and commodities face numerous challenges to remain in business. One major philosophy used by SMEs these days is the implementation of lean manufacturing to get solutions for various issues they encounter. But is lean getting sustained over time? The purpose of this research is to design a Sustainable Lean Performance Index (SLPI) to assess the sustainability of lean systems and to pinpoint the variables that might be present as potential lean system inhibitors which hinder the sustainability of leanness.

Design/methodology/approach
A multi-level sustainable lean performance model is constructed and presented based on the literature research, field investigation and survey conducted by administering a questionnaire. Fuzzy logic approach is used to analyse the multi-level model.

Findings
SLPI for the SMEs is found using fuzzy logic approach. Additionally, the ranking score system is applied to categorise attributes into weak and strong categories. The performance of the current lean system is determined to be “fair” based on the Euclidean distance approach and the SLPI for SMEs.

Research limitations/implications
This work is concentrated only in South India because of the country’s vast geographical area and rich and wide diversity in industrial culture of the nation. Hence, more work can be done incorporating the other parts of the country and can analyse the lean behaviour in a comparative manner.

Practical implications
The generalised sustainable lean model analysed using fuzzy logic identifies the inhibitors and level of performance of SMEs in South India. This can be implemented to find out the level of performance in the SMEs after a deeper study and analysis around the SMEs of the country.

Originality
The sustainable assessment of lean parameters in the SMEs of India is found to be very less in literature, and it lacks profundity. The model established in this study assesses the sustainability of the lean methodology adopted in SMEs by considering the lean and sustainability attributes along with enablers like technology, ethics, customer satisfaction and innovation with the aid of fuzzy logic.
Monetary impacts should be considered in biological invasion risk assessments
Authors: Soto Ismael , Haubrock Phillip J. , Cuthbert Ross N. , Renault David , Probert Anna F. , Tarkan Ali Serhan 
Published: October 2023

Abstract

Biological invasions pose a significant threat to biodiversity, planetary health and socio‐economies worldwide. Prioritizing invasive species for management is crucial, given the limited economic resources available.

While global invasive species risk scoring systems exist, they currently do not incorporate fully quantitative impact metrics. However, the emergence of monetary costs as a standardized measure of invasive species impact across contexts provides an opportunity to compare species in risk assessments.

Synthesis and applications: The economic impact of invasive species should now be considered in impact and risk assessments worldwide, given the growing availability and synthesis of cost data. This will allow for more informed decision‐making regarding the allocation of resources for invasive species management.
Cognitive assistance to support individuals with traumatic brain injury using a minimal and personalised approach: A conversion mixed methods study using video analysis
Authors: Gagnon‐Roy Mireille , Bier Nathalie , Le Dorze Guylaine , Boulé‐Riley Stéphanie , Paquette Guillaume , Couture Mélanie , Bottari Carolina 
Published: October 2023

AbstractIntroductionIndividuals with traumatic brain injury (TBI) frequently need assistance to manage complex everyday activities. However, little is known about the types of cognitive assistance that can be used to facilitate optimal independence. A conversion mixed method study using video analysis was conducted to describe assistance provided by trained occupational therapists during three everyday tasks carried out in the participants' homes and surrounding environments.MethodsForty‐five people with moderate and severe TBI were tested by three occupational therapists using the Instrumental Activities of Daily Living Profile, an observation‐based assessment that documents independence in complex everyday activities and the minimal assistance required to attain task goals. Using video analysis, difficulties experienced by the people with TBI during a meal preparation and grocery shopping task, and the cognitive assistance provided by the occupational therapists in response to these difficulties, were documented. Statistical analyses were also completed to identify the main difficulties and types of cognitive assistance provided during the evaluation, for the whole group and depending on their level of independence.ResultsNine types of cognitive assistance were used by occupational therapists, including implicit (stimulating thought processes), and more explicit assistance (cueing), to facilitate task performance. When needed, motivational assistance, which consisted of encouraging participants to think for themselves, was also used. Stimulating thought processes was mostly used to support goal formulation and planning, whereas cueing was used in numerous instances. Participants with lower levels of independence received more assistance of almost all types to support them.ConclusionUsing these findings, training could be developed for caregivers and occupational therapists to support them in providing minimal and personalised cognitive assistance. Further research is needed to examine the extent to which all types of cognitive assistance are effective in helping various cognitive profiles of people with TBI attain optimal independence.
Taking a chance on outcome standardisation: A cross‐sectional analysis assessing the uptake of the prevention of preterm birth core outcome set in randomised controlled trials
Authors: Bratten Chance , Tham Laura , Magana Kimberly , Ward Shaelyn , Magee Trevor , Modi Jay , Jones Garrett , Fitzgerald Kyle , Hughes Griffin , Ford Alicia Ito , Vassar Matt 
Published: October 2023

AbstractObjectiveAnalyse uptake of the core outcome set (COS) within preterm birth (PTB) clinical trials.DesignOn 26 June 2023, we conducted a systematic search of phase III/IV trial registry entries regarding PTB interventions via ClinicalTrials.gov and the International Clinical Trial Registry Platform. These trials were analysed for the outcomes measured.SettingN/A.SampleAfter searching the two databases, 5257 randomised controlled trials (RCTs) were screened, resulting in 92 RCTs for analysis.MethodsInclusion criteria were the following: subjects were patients receiving an intervention for PTB, study enrolment began within 5 years prior to publication of PTB COS to 26 June 2023, and evaluated the efficacy of interventions. Authors screened and extracted data in masked, duplicate fashion, then performed an interrupted time series analysis, analysis of variance and correlation analysis.Main outcome measuresWe extracted outcomes measured by each clinical trial in our sample. Trials were analysed for the percentage of adopted outcomes from PTB COS.ResultsAfter COS publication, there was no significant change in percentage of COS outcomes measured. The most measured outcome was ‘offspring mortality’ (54.34%, 50/92) and the least measured outcome was ‘late neonatal neurodevelopment morbidity’ (3.26%, 3/92). Additionally, 22.83% (21/92) of trials measured zero outcomes related to the PTB COS.ConclusionOur results demonstrated no significant change in outcome measurement before or after PTB COS publication. We recommend focusing on both the measurement of outcomes and the assessments that are used.
Neuroprotective effect of chitosan oligosaccharide on alcohol‐induced hippocampal injury using proteomic analysis
Authors: Wang Bin , Zhao Yuke , Qu Yufei , Lu Jingyu , Yan Hua , Gu Juan , Jiang Qiqing , Xu Yanshun , Xia Wenshui 
Published: October 2023

AbstractAlcoholism is a serious public health problem, and the abuse of drinking seriously damages the health of people. Chitosan oligosaccharides (COSs) are small‐molecule oligosaccharides with amino groups that have many unique properties. The neuroprotective effect of COS on alcohol‐induced hippocampal injury in Sprague–Dawley (SD) rats was investigated. The discrimination ratio of the COS group in the Y‐maze experiment was 59.3% higher than that of the ETOH group. Meanwhile, the discrimination index was less than 0 in the ETOH group but greater than 0 in the COS group during the object recognition test. The cells in the COS group were more tightly arranged than those in the ETOH group. Proteomics was used to identify differentially expressed proteins in the hippocampus. There were 27 differentially expressed proteins in the COS and ETOH group for further bioinformatic analysis. There are three enriched pathway categories, namely, primary immunodeficiency, hedgehog signaling, and sulfur relay system. Next, sonic hedgehog signaling pathway‐related proteins were verified through western blotting. The protein expression level of β‐arrestin‐2 in the COS group was 2.85 times higher than that in the ETOH group. This work may contribute to understanding the underlying mechanism of the neuroprotective effect of COS against alcohol‐induced hippocampal injury in SD rats.
Identifying demographic and environmental drivers of population dynamics and viability in an endangered top predator using an integrated model
Authors: Warlick A. J. , Himes Boor G. K. , McGuire T. L. , Shelden K. E.W. , Jacobson E. K. , Boyd C. , Wade P. R. , Punt A. E. , Converse S. J. 
Published: October 2023

AbstractKnowledge about the demographic and environmental factors underlying population dynamics is fundamental to designing effective conservation measures to recover depleted wildlife populations. However, sparse monitoring data or persistent knowledge gaps about threats make it difficult to identify the drivers of population dynamics. In situations where small, declining, or depleted populations show continued evidence of decline for unknown reasons, integrated population models can make efficient use of available data to improve our understanding of demography, provide fundamental insights into factors that may be limiting recovery, and support conservation decisions. We used mark‐resight and aerial survey data from 2004 to 2018 to build a Bayesian integrated population model for the Cook Inlet population of beluga whales (Delphinapterus leucas), which is listed as endangered under the U.S. Endangered Species Act. We examined the effects of prey availability and oceanographic conditions on beluga vital rates and conducted a population viability analysis to predict extinction risk across a range of hypothetical changes in beluga survival and reproduction. Our results indicated that while the survival of breeding females (0.97; 95% CI: 0.95–0.99) and young calves (0.92; 0.80–0.98) was relatively high, the survival of nonbreeders (0.94; 0.91–0.97) and fecundity (0.28; 0.22–0.36) may be depressed. Furthermore, our analysis indicates that the population will likely continue to decline, with a 17–32% probability of extinction in 150 years. Our model highlights the utility of integrated population modeling for maximizing the usefulness of available data and identifying factors contributing to the failure of protected populations to recover. This framework can be used to evaluate proposed conservation and recovery efforts for this and other endangered species.