bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study
Authors: Rizany Selly , Abadi Adnan , Agustiansyah Patiyus , Nurtjahyo Awan , Irfanuddin  , Usman Fatimah , Hartati  , Mirani Putri , Krisna Ratih , Amran Rizani , Prasetiyo Muhammad Ath Thaariq 
Published: February 2024

Objective: To assess the correlation between vitamin D levels, dysmenorrhea intensity measured by the visual analogue scale (VAS), and the stage of endometriosis determined by the American Society of Reproductive Medicine (ASRM) grading score.
Methods: A cross-sectional study was conducted involving 37 women diagnosed with suspected endometriosis who met the inclusion and exclusion criteria. The aim was to determine the correlation between vitamin D levels, dysmenorrhea VAS scores, and the ASRM endometriosis stage at RSUP Dr. Mohammad Hoesin Palembang from November 2021 to April 2022. Bivariate analysis was employed to assess correlation, utilizing Pearson's correlation test and the Spearman Rank correlation test as an alternative method.
Results: There was a significant positive correlation between vitamin D levels and the VAS score for dysmenorrhea (r = 0.678; p = 0.000) and a very strong positive correlation between vitamin D levels and the degree of endometriosis (r = 0.774; p = 0.000) based on Spearman Rho's correlation test.
Conclusion: There is a significant relationship between vitamin D levels with the VAS score of dysmenorrhea and the degree of endometriosis ASRM.
Keywords: american society of reproductive medicine, endometriosis, visual analogue scale, vitamin D
Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding
Authors: Izaak Revynca Petronella 
Published: February 2024

Objective: To evaluate the comparative effect of carbetocin vs. other uterotonic agents in the prevention of the occurrence of postpartum bleeding.
Methods: Medical search engines like Pubmed, Google Scholar, and Cochrane are used for literature searches. The year period covered by the literature is 2013–2023. “Carbetocin” or “long-acting oxytocin” and “uterotonic” are the essential words, together with “post-partum hemorrhage” or “post-partum bleeding.” Data analysis was performed using the RevMan 5.4 application.
Results: This study involved 12 clinical trials with a total sample of 32,312 people. Based on forest plot analysis, it was found that patients receiving carbetocin therapy had a risk of developing postpartum bleeding of 0.42 times compared to those receiving other uterotonic agents (misoprostol and oxytocin) (OR: 0.42; 95% CI: 0.26-0.68; p<0.0004; with heterogeneity p<0.00001, I2 85%)
Conclusion: With its effectiveness and efficacy, carbetocin can be considered one modality that can prevent postpartum hemorrhage. In addition, it can benefit women at risk of having a major obstetric hemorrhage.
Keywords: carbetocin, uterotonic, meta-analysis, clinical trial
River restoration in the urban landscape as a turning point in culture and hydropolitics: Narrations and case studies for the challenges of the 21 st century
Authors: Rzońca Apolinary , Zamorowska Karolina 
Published: February 2024

The purpose of this article is an interdisciplinary and cross-domain analysis of the idea of restoration of watercourses in urban landscapes. We refer to publications from the field of urban studies, ecohydrology and ecological humanities. In the first part of the article, we define the problem range and analyse the narrations of the artistic projects of the recent period dealing with blue infrastructure in cities. Next, we review case studies illustrating good practice in urban spaces involving the so-called urban-river concept. These examples will allow us to identify benefits to be found for cities, especially in the field of the fight on climate change. The article aims to outline possible solutions for the urban landscape, including opportunities to enrich the urban culture and identity.
Training cessation in 12 years old and under Age-Group Swimmers
Authors: Mello Fiori Júlia , Zacca Rodrigo , De Souza Castro Flávio Antônio 
Published: February 2024

Abstract
Objective: to verify if three-weeks of training cessation affects 200 m front crawl performance and kinematics in 12 years old and under age-group swimmers controlling for anthropometric changes.
Method: Sixteen age-group swimmers (11 girls and 5 boys, age: 10.2 ± 1.2 y) performed a 200 m front crawl test (T200) (time trial) PRE- and POST three-weeks (off-season), where performance, kinematics and anthropometrics variables were obtained.
Results: Height increased ~1.0 cm (CI: 0.70 to 1.3 cm; p < 0.001; d = 0.07). Trivial changes were observed for performance (mean diff: 3.3 s CI: -6.7 to 13.9; p = 0.69; d = 0.08) and kinematical variables (p from 0.69 to 0.84; d < 0.001 for all). High intraclass correlations (ICC: 0.69 to 0.84; p < 0.001) were observed for all variables after three-weeks, indicating stability over time.
Conclusion: Three-weeks off-season does not impair swimming T200 performance and kinematic variables in 12 years old and under age-group swimmers.
Keywords: swimming, detraining, performance, kinematics, anthropometrics
Diabetic Myonecrosis Involving Both Lower Limbs in Hemodialysis Patient: A Rare Complication of Diabetes.
Authors: Chowdhury Md Farhad Hasan , Anwar Mohammed Rashed , Hossain Momtaz , Deb Nath Palash Kumar , Nargis Tania 
Published: February 2024

Diabetic myonecrosis (DMN) is the term used for spontaneous ischemic necrosis of skeletal muscle, unrelated to atheroembolism or occlusion of major arteries. DMN is a rare microangiopathic disorder that can present as an acutely painful and swollen limb in patients with established diabetes mellitus. Muscles of the thighs are commonly affected in DMN. The condition can be diagnosed noninvasively with magnetic resonance imaging and resolves with analgesia, bed rest, and glycemic control. The majority of patients with DMN have diabetic nephropathy, yet this condition is not widely recognized. Due to uncommon presentation, lack of specific marker of investigation, diagnosis is often missed, resulting in unnecessary and deleterious interventions such as antibiotics, muscle biopsies, and surgery; the latter two of which can prolong recovery. Here, we report a patient on hemodialysis who is ultimately diagnosed as DMN affecting both lower limb and treated successfully.
Mugda Med Coll J. 2022; 5(2): 113-116
REPRESENTASI CITRA MUSLIMAH DALAM IKLAN WARDAH COSMETICS “BERGERAK HIDUPKAN HARAPAN” EDISI RAMADHAN 1443 H
Authors: Amaniah Suci , Afyatul Masruroh Sayyidah 
Published: February 2024

Advertising is a promotional medium used by various companies to increase sales of services and goods. Television commercials are believed to be able to influence audiences to purchase products. Moreover, using female figures can increase the appeal of an ad because of their beauty. Many commercials feature female figures showing their curves, such as those featuring women in short, tight clothing. However, unlike Wardah Cosmetics' commercial "Bergerak Hidupkan Harapan" Ramadan 1443 H edition, this ad features women wearing hijab and decently dressed. In addition, Wardah's ads not only showed physical beauty but also the beauty of the heart. This research focuses on the image of Muslim women shown in Wardah Cosmetics' commercial "Bergerak Hidupkan Harapan" Ramadan 1443 H edition. This research concludes that first, there were 15 significant scenes presenting a modern Muslimah, marked by the current Muslim style of clothing and hijab. However, the hijab style used does not fit Islamic law because it does not cover the chest. And the use of Wardah's products on Muslimah actresses leads the audience to keep their faces clean no matter how busy they are and to maintain their appearance at all opportunities. Second, muslimah are depicted as the image of pigura and pinggan. The image of the pigura in this not only shows beauty physically, but also has a beautiful heart. Then the image of pinggan in this commercial shows women in the kitchen not only for cooking but also as a business.
Akselerasi pendidikan karakter melalui integrasi kearifan lokal dalam Pendidikan Pancasila dan Kewarganegaraan
Authors: Erlande Rike 
Published: February 2024

Kajian ini bertujuan untuk mengeksplorasi tentang pengalaman dan tantangan yang dihadapi guru dalam mengembangkan pembelajaran PPKn berbasis kearifan lokal dengan memanfaatkan teknologi guna menguatkan karakter peserta didik. Metode yang digunakan adalah metode penelitian kualitatif. Pengumpulan data dilakukan melalui wawancara mendalam dengan beberapa guru yang telah mengembangkan materi PPKn berbasis kearifan lokal dengan memanfaatkan teknologi dalam pembelajaran. Hasil penelitian menunjukkan bahwa guru-guru tersebut telah berhasil mengintegrasikan kearifan lokal dalam pembelajaran PPKn dengan memanfaatkan teknologi. Teknologi mampu memfasilitasi proses pembelajaran yang lebih interaktif dan menarik bagi peserta didik. dan memungkinkan guru untuk mengakses sumber daya pendukung pembelajaran dengan lebih mudah. Namun, terdapat beberapa tantangan yang dihadapi oleh guru dalam mengembangkan pembelajaran PPKn berbasis kearifan lokal dengan pemanfaatan teknologi sehingga perlu diambil beberapa langkah konkret baik oleh guru maupun pemerintah untuk mengatasi tantangan tersebut. Integrasi pembelajaran dengan kearifan lokal ini diharapkan mampu mengakselerasi pendidikan karakter di Indonesia.
Association between blood urea nitrogen levels and the risk of diabetes mellitus in Chinese adults: secondary analysis based on a multicenter, retrospective cohort study
Authors: Du Jie , Zhang Wei , Niu Jing , Wang Shuili 
Published: February 2024

BackgroundAs one of the recognized indicators of kidney function, blood urea nitrogen (BUN) is a key marker of metabolic diseases and other diseases. Currently, data on the relationship of BUN levels with the risk of diabetes mellitus (DM) in Chinese adults are sparse. This study aimed to investigate the correlation between BUN levels and DM risk in Chinese adults.Data and methodsThis study is a secondary analysis of a multicenter, retrospective cohort study with data from the Chinese health screening program in the DATADRYAD database. From 2010 to 2016, health screening was conducted on 211833 Chinese adults over the age of 20 in 32 locations and 11 cities in China, and there was no DM at baseline. Cox proportional hazards regression analysis assessed an independent correlation between baseline BUN levels and the risk of developing DM. The Generalized Sum Model (GAM) and smoothed curve fitting methods were used to explore the nonlinear relationship. In addition, subgroup analyses were performed to assess the consistency of correlations between different subgroups and further validate the reliability of the results.ResultsAfter adjusting for potential confounding factors (age, sex, etc.), BUN levels were positively correlated with the occurrence of DM (HR=1.11, 95% CI (1.00~1.23)). BUN level had a nonlinear relationship with DM risk, and its inflection point was 4.2mmol/L. When BUN was greater than 4.2mmol/L, BUN was positively correlated with DM, and the risk of DM increased by 7% for every 1 mmol/L increase in BUN (P&lt;0.05). Subgroup analysis showed that a more significant correlation between BUN levels and DM was observed in terms of sex, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), alaninetransaminase (ALT), aspartate transaminase (AST), creatinine (Cr) and smoking status (interaction P&lt;0.05).ConclusionHigh levels of BUN are associated with an increased risk of DM in Chinese adults, suggesting that active control of BUN levels may play an important role in reducing the risk of DM in Chinese adults.
Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer
Authors: Sun Jingtao , Tian Tian , Wang Naiqiang , Jing Xuehui , Qiu Laiyuan , Cui Haochen , Liu Zhao , Liu Jikai , Yan Lei , Li Dawei 
Published: February 2024

BackgroundRecently, serum sialic acid (SA) has emerged as a distinct prognostic marker for prostate cancer (PCa) and bone metastases, warranting differential treatment and prognosis for low-volume (LVD) and high-volume disease (HVD). In clinical settings, evaluating bone metastases can prove advantageous.ObjectivesWe aimed to establish the correlation between SA and both bone metastasis and HVD in newly diagnosed PCa patients.MethodsWe conducted a retrospective analysis of 1202 patients who received a new diagnosis of PCa between November 2014 and February 2021. We compared pretreatment SA levels across multiple groups and investigated the associations between SA levels and the clinical parameters of patients. Additionally, we compared the differences between HVD and LVD. We utilized several statistical methods, including the non-parametric Mann-Whitney U test, Spearman correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression.ResultsThe results indicate that SA may serve as a predictor of bone metastasis in patients with HVD. ROC curve analysis revealed a cut-off value of 56.15 mg/dL with an area under the curve of 0.767 (95% CI: 0.703-0.832, P &lt; 0.001) for bone metastasis versus without bone metastasis and a cut-off value of 65.80 mg/dL with an area under the curve of 0.766 (95% CI: 0.644-0.888, P = 0.003) for HVD versus LVD. Notably, PCa patients with bone metastases exhibited significantly higher SA levels than those without bone metastases, and HVD patients had higher SA levels than LVD patients. In comparison to the non-metastatic and LVD cohorts, the cohort with HVD exhibited higher levels of alkaline phosphatase (AKP) (median, 122.00 U/L), fibrinogen (FIB) (median, 3.63 g/L), and prostate-specific antigen (PSA) (median, 215.70 ng/mL), as well as higher Gleason scores (&gt; 7). Multivariate logistic regression analysis demonstrated that an SA level of &gt; 56.15 mg/dL was independently associated with the presence of bone metastases in PCa patients (OR = 2.966, P = 0.018), while an SA level of &gt; 65.80 mg/dL was independently associated with HVD (OR = 1.194, P = 0.048).ConclusionThe pretreatment serum SA level is positively correlated with the presence of bone metastases.
Comprehensive management of children and adolescents with type 1 diabetes mellitus through personalized physical exercise and education using an mHealth system: The Diactive-1 study protocol
Authors: Hormazábal-Aguayo Ignacio , Muñoz-Pardeza Jacinto , López-Gil José Francisco , Huerta-Uribe Nidia , Chueca-Guindulain María J. , Berrade-Zubiri Sara , Burillo Sánchez Elisabet , Izquierdo Mikel , Ezzatvar Yasmin , García-Hermoso Antonio 
Published: February 2024

IntroductionThe use of new technologies presents an opportunity to promote physical activity, especially among young people with type 1 diabetes (T1DM), who tend to be less active compared to their healthy counterparts. The aim of this study is to investigate the impact of a personalized resistance exercise program, facilitated by the Diactive-1 App, on insulin requirements among children and adolescents diagnosed with T1DM.Methods and analysisA minimum of 52 children and adolescents aged 8-18 years, who were diagnosed with T1DM at least 6 months ago, will be randomly assigned to either a group engaging in an individualized resistance exercise program at least 3 times per week over a 24-week period or a waiting-list control group. The primary outcome will be the daily insulin dose requirement. The secondary outcomes will include glycemic control, cardiometabolic profile, body composition, vascular function, physical fitness, 24-hour movement behaviors, diet, and psychological parameters. The usability of the app will also be assessed.Ethics and disseminationEthical approval to conduct this study has been granted by the University Hospital of Navarra Research Board (PI_2020/140). Parents or legal guardians of minors participating in the study will provide written consent, while children and adolescents will sign an assent form to indicate their voluntary agreement. The trial’s main findings will be shared through conference presentations, peer-reviewed publications, and communication directly with participating families. This study aims to offer valuable insights into the holistic management of children and adolescents with T1DM by utilizing personalized exercise interventions through an mHealth system.Trial registrationNCT06048757
Research on stem cell therapy for spinal cord injury: a bibliometric and visual analysis from 2018–2023
Authors: Liu Ruxing , Peng Bo , Yuan Jie , Hu Jiahao , Yang Jianxin , Shan Nan , Li Qichao , Zhao Bin , Xu Chaojian , Wang Yongfeng 
Published: February 2024

Objectives: The aim of this study was to conduct a bibliometric analysis of the literature on stem cell treatment for spinal cord injury to gain an intuitive understanding of how the field is progressing, discover topics of interest, and determine what development trends are emerging in this field.Background: Spinal cord injury and its complications often cause an enormous economic burden, and postinjury repair and treatment have always been challenging in clinical and scientific research. Stem cell therapy for spinal cord injury can prevent immune rejection and induce the release of neuroprotective and anti-inflammatory factors to reduce the production of stress-related proteins, reactive oxygen species, and inflammatory reactions.Methods: We analyzed the number and quality of publications in the field of stem cell therapy in spinal cord injury between 2018.01.01 and 2023.06.30 in the core collection database of Web of Science. CiteSpace and VOSviewer were used to sort and summarize these studies by country, institution, authors' publications, and collaborative networks. In addition, the research topics of interest were identified and summarized.Results: This study ultimately included 2,150 valid papers, with the number of publications showing a gradual upward trend. The country, institution, author and journal with the greatest number of publications and citations are China, the Chinese Academy of Sciences, Dai JW, and the International Journal of Molecular Sciences, respectively. The top three high-frequency keyword clusters were hereditary paraplegia, reactive astrocytes and tissue engineering.Conclusion: With the help of visual analysis, we identified general trends and research topics of interest in the field of spinal cord injury over the last 5 years. Our findings suggest that stem cell transplantation for spinal cord injury and exosome therapy may be a focus of future research. This study provides a foundation for future research on stem cell therapy as well as clinical efforts in this field.
Development of autoimmune thyroid disease after COVID-19 infection: case report
Authors: Du Si-na , Chen Jian-wei , Li Wei , Wang Meng-chuan , Mao Yu-shan 
Published: February 2024

BackgroundSARS-CoV-2 could trigger multiple immune responses, leading to several autoimmune diseases, including thyroid diseases. Many cases of thyroid diseases caused by COVID-19 infection have been reported. Here, we describe the disease development of patients with autoimmune thyroid disease after COVID-19 infection.MethodsThe clinical characteristics, diagnosis and treatment of five different patients with autoimmune thyroid disease after COVID-19 infection were reported.ResultsFemale patients with primary autoimmune thyroid disease which have been stable for many years were reported. One month after COVID-19 infection, the disease has undergone different evolution. Case 1, a patient with history of long-term stable Hashimoto’s thyroiditis, suddenly suffered from Graves disease after COVID-19 infection. Case 2, a patient with history of long-term stable Hashimoto’s thyroiditis with thyroid nodules, suddenly suffered from Graves disease after infection. Case 3, a patient with history of long-term stable Graves disease, suddenly suffered from worsening after infection. The above three cases showed thyroid-stimulating antibodies were enhanced. Case 4, a patient with history of previous hypothyroidism had an increase in thyroid-related antibody (TPOAb and TRAb) activity after infection, followed by a marked worsening of hypothyroidism. Case 5, a patient with no history of thyroid disease suddenly developed controllable “thyrotoxicosis” after infection, suggesting the diagnosis of painless thyroiditis.ConclusionThe five case reports show a different development of the primary autoimmune thyroid disease after COVID-19 infection. The change in the trend of thyroid disease is closely related to the immune response induced by SARS-CoV-2 infection.
Modifiable dementia risk factors and AT(N) biomarkers: findings from the EPAD cohort
Authors: Roccati Eddy , Bindoff Aidan David , Collins Jessica Marie , Eastgate Joshua , Borchard Jay , Alty Jane , King Anna Elizabeth , Vickers James Clement , Carboni Margherita , Logan Chad ,   EPAD Consortium
Published: February 2024

IntroductionModifiable risk factors account for a substantial proportion of Alzheimer’s disease (AD) cases and we currently have a discrete AT(N) biomarker profile for AD biomarkers: amyloid (A), p-tau (T), and neurodegeneration (N). Here, we investigated how modifiable risk factors relate to the three hallmark AT(N) biomarkers of AD.MethodsParticipants from the European Prevention of Alzheimer’s Dementia (EPAD) study underwent clinical assessments, brain magnetic resonance imaging, and cerebrospinal fluid collection and analysis. Generalized additive models (GAMs) with penalized regression splines were modeled in the AD Workbench on the NTKApp.ResultsA total of 1,434 participants were included (56% women, 39% APOE ε4+) with an average age of 65.5 (± 7.2) years. We found that modifiable risk factors of less education (t = 3.9, p &lt; 0.001), less exercise (t = 2.1, p = 0.034), traumatic brain injury (t = −2.1, p = 0.036), and higher body mass index (t = −4.5, p &lt; 0.001) were all significantly associated with higher AD biomarker burden.DiscussionThis cross-sectional study provides further support for modifiable risk factors displaying neuroprotective associations with the characteristic AT(N) biomarkers of AD.