bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining SKY92 gene expression profiling and FISH (according to R2‐ISS) defines ultra‐high‐risk Multiple Myeloma
Authors: Zhou Xiang , Hofmann Annika , Engel Benedict , Vogt Cornelia , Nerreter Silvia , Tamamushi Yoko , Schmitt Friederike , leberzammer Maria , Stanojkovska Emilia , Truger Marietta , Xiao Xianghui , Riedhammer Christine , Steinhardt Maximilian J. , John Mara , Mersi Julia , Han Seungbin , Munawar Umair , Waldschmidt Johannes M. , Haferlach Claudia , Einsele Hermann , Rasche Leo , Kortüm K. Martin 
Published: January 2025

AbstractThe definition of high‐risk (HR) multiple myeloma (MM) is still a matter of debate. We prospectively evaluated the HR detection using FISH in combination with SKY92 gene expression profiling in 258 MM patients (newly diagnosed [ND] MM: n = 109; relapsed/refractory [RR] MM: n = 149). HR SKY92 was significantly enriched in RRMM (57/121, 47.1%) compared with NDMM (17/95, 17.9%) (p < 0.0001). RRMM patients with HR SKY92 showed significantly shorter progression‐free survival (PFS) (p < 0.0001) and overall survival (OS) (p < 0.0001) than SKY92 standard‐risk (SR). In NDMM, HR SKY92 also indicated a significantly inferior PFS (p < 0.0001) in comparison with SR. We combined SKY92 with FISH (HR: t(4;14), del17p, +1q21 according to R2‐ISS) in 181 patients (NDMM: n = 79; RRMM: n = 102). We found a discrepancy between both risk stratification systems, with only 49 (27.1%) patients being defined as HR by both SKY92 and FISH (“double HR”). In terms of survival outcomes, “double HR” presented a negative prognostic factor for PFS in both NDMM (p < 0.0001) and RRMM (p < 0.0001). Furthermore, “double‐HR” patients showed the worst OS (p = 0.000 13) in RRMM. Additionally, whole genome sequencing (WGS) revealed CRBN mutation (n = 3) and bi‐allelic events (mutation and/or deletion) in TP53 (n = 7) and TNFRSF17 (n = 1). Altogether, we provide the first prospective real‐world evidence that the combination SKY92 and FISH (according to R2‐ISS) identifies a subset of patients with ultra‐HR MM, and WGS complements SKY92 and FISH in MM risk stratification.
The impact of hysterectomy for benign uterine tumors on subsequent ovarian reserve, lower urinary tract symptoms, and sexual function: A prospective multidirectional short‐term analysis
Authors: Hsiao Yu‐Ju , Chuang Fei‐Chi , Yang Tsai‐Hwa , Huang Kuan‐Hui , Chen Wen‐Hsin , Kung Fu‐Tsai 
Published: January 2025

AbstractObjectiveTo evaluate the effects of hysterectomy for benign uterine tumors on subsequent ovarian reserve, sexual function, and lower urinary tract symptoms (LUTS).MethodsThe present study was a prospective longitudinal analysis that recruited patients aged 35–45 years who underwent simple hysterectomy without oophorectomy for symptomatic benign uterine tumors. Anti‐Müllerian hormone (AMH) and serum sex hormone profiles, including follicle‐stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, and total testosterone, were measured at four timepoints: before hysterectomy, and 3, 6, and 12 months postoperatively. Participants completed the following questionnaires at these timepoints: Urinary Distress Inventory (UDI‐6), Incontinence Impact Questionnaire (IIQ‐7), and Pelvic Organ Prolapse/Urinary Incontinence and Sexual Function Questionnaire (PISQ‐12) short form.ResultsA total of 36 patients completed the study. Serum AMH levels significantly declined post‐hysterectomy compared with preoperative levels. Both UDI‐6 and IIQ‐7 scores significantly decreased post‐hysterectomy compared with preoperative scores. No differences were observed in serum FSH, LH, estradiol, progesterone, and testosterone levels before and after hysterectomy. No significant differences were found in the short form of PISQ‐12 before and after hysterectomy.ConclusionThe present study demonstrated that simple hysterectomy with ovarian preservation had detrimental effects on ovarian reserves, whereas LUTS showed improvement. Furthermore, sexual dysfunction was not likely to occur within the first postoperative year.
Left Ventricular Hemodynamic Forces Changes in Fabry Disease: A Cardiac Magnetic Resonance Study
Authors: Li Jialin , Liang Shichu , Xu Ziqian , Wan Ke , Pu Lutong , Wang Jie , Han Yuchi , Chen Yucheng 
Published: January 2025

BackgroundHemodynamic force (HDF) from cardiac MRI can indicate subclinical myocardial dysfunction, and help identify early cardiac changes in patients with Fabry disease (FD). The hemodynamic change in FD patients remains unclear.PurposeTo explore HDF changes in FD and the potential of HDF measurements as diagnostic markers indicating early cardiac changes in FD.Study TypeSingle‐center, prospective, observational study.PopulationForty‐six FD patients (age: 38 ± 12, females: 45.65%) and 46 sex‐ and age‐matched healthy controls (HCs).Field Strength/Sequence3 T, cardiac MRI including steady‐state free precession cine imaging (during multiple breath‐holds), phase‐sensitive inversion recovery sequence for late gadolinium enhancement (LGE) imaging, and motion‐corrected modified Look–Locker inversion recovery sequence for T1 mapping.AssessmentAnalysis of strains and HDF were performed on the cine imaging. HDF parameters includes apical‐basal force, systolic impulse, systolic peak, systolic‐diastolic transition, diastolic deceleration, and atrial thrust. Moreover, FD patients were categorized with left ventricular hypertrophy (LVH+) (the maximal wall thickness >12 mm) or without LVH (LVH−). Mainz Severity Score Index (MSSI) score was calculated to measure the progression of FD.Statistical TestsGroup comparison tests, logistic regression, and receiver operating characteristic curve (ROC) were performed. A P‐value <0.05 was considered statistically significant.ResultsFD patients showed significantly lower native T1 (1161.1 ± 55.4 vs. 1202.8 ± 42.0 msec) and higher systolic impulse (33.8 ± 9.9 vs. 24.8 ± 9.5%). The systolic impulse in HDF analysis increased even in the pre‐hypertrophic stage. The increased myocardial global longitudinal strain (r = 0.419) and systolic impulse (r = 0.333) showed positive correlations with a higher MSSI score. The AUC of systolic impulse and global native T1 showed no significant difference (0.764 vs. 0.790, P = 0.784).Data ConclusionIncreased systolic impulse and systolic peak can be observed in FD patients. Systolic impulse showed potential ability for screening pre‐LVH FD patients and correlated with disease severity in FD patients.Plain Language SummaryThis study explored hemodynamic changes in patients with Fabry disease (FD) using hemodynamic force (HDF) analysis based on cardiac MRI. 46 FD patients were included and analysis of cardiac function, native T1, strains, and hemodynamic changes on cardiac MRI images were performed. The results showed that systolic impulse and systolic peak of HDF analysis were increased in FD patients, and systolic impulse may increase even in the pre‐hypertrophic stage. Systolic impulse was correlated with disease severity in patients with FD, which may be a potential image‐based diagnosis and monitoring marker in FD patients.Evidence Level1Technical EfficacyStage 2
Illness perception, cardiovascular disease risk factors knowledge, medication knowledge, and adherence among post‐myocardial infarction patients who completed phase 2 intensive cardiac rehabilitation program
Authors: Koh Hock Peng , Tang Jiaa Yinn , Jagan Nirmala , Khong Ying Sin , R. Nagarajah Jivanraj , Lim Karen Seok Chuang , Mukundadevan Vijayan 
Published: January 2025

AbstractBackgroundCardiovascular disease (CVD) is the principal cause of death globally and in Malaysia. In Malaysia, a 4‐ to 6‐week subacute cardiac rehabilitation following hospital discharge is available for individuals who have experienced a myocardial infarction (MI) and involves a multidisciplinary approach that includes physicians, pharmacists, and other health care professionals.AimThis study aimed to assess the illness perception, CVD risk factor knowledge, medication knowledge, and adherence among individuals who completed a phase 2 intensive cardiac rehabilitation program after post‐MI and their associated parameters.MethodThis single‐centre, prospective study recruited individuals who had had a MI and participated in a cardiac rehabilitation program at a tertiary hospital from 1 August 2019–31 May 2020 using convenience sampling. Primary endpoints included Brief Illness Perception Questionnaire (BIPQ) score, CVD risk factor score, medication knowledge score (assessed using the Dose, Frequency, Indication, and Method of Administration [DFIT] method), medication adherence (assessed using A Single Question [ASQ]), and hospital readmission within 30 days. Associations between these endpoints were analysed. Ethical approval was granted by the Medical Research and Ethics Committee, Ministry of Health Malaysia (Reference no: NMRR‐19‐1091‐48 132) and the study conforms with Declaration of Helsinki. Informed consent was obtained from all participants via distribution of a patient information sheet to potential participants explaining their participation was voluntary and all data would be anonymised. Written consent forms were obtained from all participants prior to their completion of the questionnaire.ResultsSixty‐seven participants with a mean age (±standard deviation) of 53.8 (±8.4) years and predominantly male (n = 53, 79.1%) were recruited. The median BIPQ, CVD risk factor, and medication knowledge scores (interquartile range [IQR]) were 34 (IQR 29–39), 3 (IQR 2–4), and 87.5 (IQR 75.0–94.0), respectively. Most (n = 60, 89.6%) participants adhered to medications. Eleven (16.4%) participants had hospital readmission within 30 days. A higher BIPQ (p = 0.037) and medication knowledge scores (p = 0.046) were significantly associated with medication adherence.ConclusionIndividuals who completed the intensive phase 2 cardiac rehabilitation program after a MI demonstrated moderate illness perception of their CVD and good medication knowledge, both of which were associated with medication adherence. However, their knowledge of CVD risk factors was suboptimal and required attention. To improve the overall outcomes, cardiac rehabilitation programs need to be re‐strategised.
Dependence of Oleic Acid Ozonolysis Rate on Film Thickness From Surface to Bulk Phases: Experimental and Modeling Approaches
Authors: Hata Hiroo , Hoshino Shoma , Fujita Michiya , Tonokura Kenichi 
Published: January 2025

ABSTRACTThe surface and bulk reactions involved in alkene ozonolysis were investigated via reaction‐system modeling using oleic acid (OA) as the representative alkene. Fourier transform infrared spectroscopy (FITR) confirmed the production of several products, including ketones and esters, as reported previously. Kinetic analysis of the experimental results indicated that the ozonolysis rate‐constant was 14.6 times higher on the OA surface than in the liquid‐bulk phase. Reaction‐diffusion equation modeling of the surface/bulk kinetics of OA ozonolysis indicated that approximately 80% of the ozonolysis occurred on the surface of the OA thin films, over different thickness ranges, with the same result observed for all thicknesses examined (0.5–10 µm). The rate constants of the surface and bulk phase kinetics and the diffusivity of the reaction system do not affect the heterogeneousness of OA ozonolysis, indicating that the constant kinetics of surface/bulk reactions could be applied to the various size of particulate matter evaluated by air quality modeling.
Calcium carbonate and phosphorus interactions in inland waters
Authors: Corman Jessica R. 
Published: January 2025

AbstractPhosphorus, an element essential to all life, is impacted by calcium carbonate (CaCO3) co‐precipitation and dissolution dynamics across aquatic ecosystems. Changes to climate, hydrology, and eutrophication, coupled with differences in terminology related to naming CaCO3‐producing ecosystems (i.e., chalk, carbonate, karst, travertine), point to the urgency and challenges in understanding this portion of the phosphorus cycle. Forms of CaCO3 vary across inland aquatic ecosystems, from “whiting events” in open waters to massive travertine or tufa formations to cemented layers on basal resources. And, across lakes, streams, and wetlands, periphyton mats and microbialites may form in photic regions. These biogenic carbonate structures beg the question: if aerobic photosynthesis promotes CaCO3 precipitation, but CaCO3 precipitation sequesters P, is this a challenge or opportunity for organisms? This review considers that question and others to better characterize this unexpectedly dynamic and influential portion of a major biogeochemical cycle.
Exponential Stability of Higher Order Fractional Neutral Stochastic Differential Equation Via Integral Contractors
Authors: Chalishajar Dimplekumar N. , Kasinathan Dhanalakshmi , Kasinathan Ramkumar , Kasinathan Ravikumar 
Published: January 2025

ABSTRACTThe well‐posedness results for mild solutions to the fractional neutral stochastic differential system with Rosenblatt process with Hurst index is discussed in this article. To demonstrate the results, the concept of bounded integral contractors is combined with the stochastic result and sequencing technique. In contrast to previous publications, we do not need to specify the induced inverse of the controllability operator to prove the stability results, and the relevant nonlinear function does not have to meet the Lipschitz condition. Furthermore, exponential stability results for neutral stochastic differential systems with Poisson jump have been established. Finally, an application to demonstrate the acquired results is discussed. We demonstrate the fractional Zener model for wave equation obeying the viscoelastic materials as a practical application of the system studied, which is a generalization of classical wave equation.
New Oscillation Criteria for H‐Difference Equation With Oscillatory Periodic Coefficients
Authors: Bolat Yasar , Gokteke Reyhan 
Published: January 2025

ABSTRACTIn this manuscript, new oscillation criteria are given for solutions of h‐order delay difference equation in the equation (1.1). There, four cases of are considered: for , as oscillatory periodic sequences with periods and and a quickly oscillating sequence such that . It is well‐known that coefficient functions have a very important role in the behavior of the solutions of an equation. The coefficient sequence has been considered as positive sequences in all oscillation criteria so far. But it is considered as oscillatory periodic sequences and quickly oscillatory sequences for the first time in this study. We use a new technique to prove our results. Also, some examples are provided to demonstrate the effectiveness of the main results.
Incidence of Radiologically Confirmed Fractures in Adults With Duchenne Muscular Dystrophy
Authors: Langlands Gavin , McKechnie Jennifer , Farrugia Maria E. , Wong Sze Choong 
Published: January 2025

ABSTRACTIntroduction/AimsAn increased risk of low trauma fractures is well documented in children and adolescents with duchenne muscular dystrophy (DMD). There is limited evidence regarding the fracture incidence of adults with DMD. The aim of this study was to examine radiologically confirmed fractures in adults with DMD and review bone health monitoring.MethodsThis was a retrospective review of all adult males ≥ 16 years with DMD under the care of adult physicians in the West of Scotland (2013–2022). Information regarding fractures, bone health monitoring, and bisphosphonate therapy was collected.ResultsThirty‐six men (median age at first visit 18.8 years) with DMD were included. Twelve were taking corticosteroids at first review, and a further 12 had previously been taking corticosteroids that were discontinued in childhood or adolescence. The fracture incidence rate was higher in the corticosteroid group (888.9 per 10,000 person years (95% CI 242.2–2275.9)) than in those not on corticosteroids (156.3 per 10,000 person years (95% CI 32.2–456.6)). Eighteen had lateral spine radiographs for vertebral fracture assessment and 15 had a DXA scan for bone density assessment during the follow‐up period.DiscussionThe fracture incidence in adult men with DMD is more than double that of UK men aged 18–49 years old, with an even higher incidence in those treated with corticosteroids. Fewer than half of the study population underwent bone monitoring. There is a need for enhanced clinical guidance for the monitoring and management of osteoporosis during transition and throughout adulthood.
Cerebrovascular Reactivity Mapping in Brain Tumors Based on a Breath‐Hold Task Using Arterial Spin Labeling
Authors: Calvo‐Imirizaldu Marta , Solis‐Barquero Sergio M. , Aramendía‐Vidaurreta Verónica , García de Eulate Reyes , Domínguez Pablo , Vidorreta Marta , Echeveste José I. , Argueta Allan , Cacho‐Asenjo Elena , Martinez‐Simon Antonio , Bejarano Bartolomé , Fernández‐Seara María A. 
Published: January 2025

ABSTRACTHemodynamic measurements such as cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) can provide useful information for the diagnosis and characterization of brain tumors. Previous work showed that arterial spin labeling (ASL) in combination with vasoactive stimulation enabled simultaneous non‐invasive evaluation of both parameters, however this approach had not been previously tested in tumors. The aim of this work was to investigate the application of this technique, using a pseudo‐continuous ASL (PCASL) sequence combined with breath‐holding at 3 T, to measure CBF and CVR in high‐grade gliomas and metastatic lesions, and to explore differences across tumoral‐peritumoral regions and tumor types. To that end, 27 patients with brain tumor were studied. Baseline CBF and CVR were measured in tumor, edema, and gray matter (GM) volumes‐of‐interest (VOIs). Peritumoral ipsilateral ring‐shaped VOIs were also generated and mirrored to the contralateral hemisphere. Differences in baseline CBF and CVR were evaluated between contralateral and ipsilateral GM, contralateral and ipsilateral peritumoral rings, and among VOIs and tumor types. CBF in the tumor was higher in grade 4 gliomas than metastases. In grade 4 gliomas, edema had lower CBF than the tumor and contralateral GM. CVR values were different between grade 3 and grade 4 gliomas, and between grade 4 and metastases. CVR values in the tumor were lower compared to the contralateral GM. Differences in CVR between contralateral and ipsilateral‐ring VOIs were also found in grade 4 gliomas, presumably suggesting tumor infiltration within the peritumoral tissue. A cut‐off value for CVR of 27.9%‐signal‐change is suggested to differentiate between grade 3 and grade 4 gliomas (specificity = 83.3%, sensitivity = 70.6%). In conclusion, CBF and CVR mapping with ASL offered insights into the perilesional environment that could help to detect infiltrative disease, particularly in grade 4 gliomas. CVR emerged as a potential biomarker to differentiate between grade 3 and grade 4 gliomas.
Open‐Loop Control of Shallow Water Waves in a Tube With Moving Boundary in Material‐Fixed Coordinates
Authors: Mayer Luca , Woittennek Frank 
Published: January 2025

ABSTRACTOpen‐loop control design for a one‐dimensional shallow water model with moving boundary and arbitrary cross section is considered. Despite the moving boundary, the transition to material‐fixed coordinates allows to reformulate the model on a constant spatial domain. The focus is on achieving smooth transitions between steady states. Apart from the transition to material‐fixed coordinates, the control design closely resembles the procedure already developed for the original model. Introducing the water level at the nonactuated boundary as a flat output, the given boundary value problem is linked to a Cauchy boundary value problem. The latter can be solved by the method of characteristics. The parameterization of the solutions of the shallow water equations obtained this way simplifies the control design. Numerical validation of the design relies on energy‐preserving spatial discretization.
The relevance of traditional knowledge for modern landscape management: Comparing past and current herding practices in Mongolia
Authors: Batdelger Gantuya , Oborny Beáta , Batjav Batbuyan , Molnár Zsolt 
Published: January 2025

Abstract

Traditional ecological knowledge (TEK) is increasingly acknowledged as key to sustainability and to the successful adaptation of local communities to rapid changes. However, implementing TEK is a major challenge in most parts of the world.

A book published 80 years ago by Sambuu Jamsran, a Mongolian agricultural minister in the 1930s, provides a unique opportunity to compare the past versus present knowledge and practices of semi‐nomadic herders. Sambuu collected information from highly respected herders during a dialogue workshop about the proper management of herds and pastures. This cooperation between a politician and the herders yielded a valuable collection of ‘best practices’.

We aimed to assess the relevance of this traditional knowledge for the successful adaptation of local communities in present Mongolia. We interviewed 31 middle‐aged or older herders about 69 pieces of advice extracted from Sambuu's book. Two questions guided our inquiries: (1) Do you agree with the advice? (2) Do people in your region adhere to it? If so, why, if not, why?

Most recommendations were still accepted as valid (77%) by herders; however, only a smaller proportion was followed (49% of all). The interviews revealed some key reasons for the abandonment of certain traditional practices in the post‐1990 era, driven by fast social‐economic changes, even though the herders were aware that the traditional practices were more proper and sustainable. The practices that were abandoned the most were those that required greater time investment, were less compatible with modern lifestyles or needed closer cooperation and better functioning institutions.

In conclusion, the Mongolian semi‐nomadic herding system exhibits adaptability to new conditions, but the development of proper new practices by herders or the government may take considerable time. As in many cases around the world, there is a time lag between the changes and the herders' responses to these changes. Herders' TEK has a vital role in developing locally adaptive solutions, while institutions have a critical role in formulating policy that can mitigate the negative impacts of rapid changes while fostering tradition‐based, sustainable and innovative practices for the future.

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