bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable positions of Weyl nodes via magnetism and pressure in the ferromagnetic Weyl semimetal CeAlSi
Authors: Cheng Erjian , Yan Limin , Shi Xianbiao , Lou Rui , Fedorov Alexander , Behnami Mahdi , Yuan Jian , Yang Pengtao , Wang Bosen , Cheng Jin-Guang , Xu Yuanji , Xu Yang , Xia Wei , Pavlovskii Nikolai , Peets Darren C. , Zhao Weiwei , Wan Yimin , Burkhardt Ulrich , Guo Yanfeng , Li Shiyan , Felser Claudia , Yang Wenge , Büchner Bernd 
Published: February 2024

AbstractThe noncentrosymmetric ferromagnetic Weyl semimetal CeAlSi with simultaneous space-inversion and time-reversal symmetry breaking provides a unique platform for exploring novel topological states. Here, by employing multiple experimental techniques, we demonstrate that ferromagnetism and pressure can serve as efficient parameters to tune the positions of Weyl nodes in CeAlSi. At ambient pressure, a magnetism-facilitated anomalous Hall/Nernst effect (AHE/ANE) is uncovered. Angle-resolved photoemission spectroscopy (ARPES) measurements demonstrated that the Weyl nodes with opposite chirality are moving away from each other upon entering the ferromagnetic phase. Under pressure, by tracing the pressure evolution of AHE and band structure, we demonstrate that pressure could also serve as a pivotal knob to tune the positions of Weyl nodes. Moreover, multiple pressure-induced phase transitions are also revealed. These findings indicate that CeAlSi provides a unique and tunable platform for exploring exotic topological physics and electron correlations, as well as catering to potential applications, such as spintronics.
Evidence for Topological Protection Derived from Six-Flux Composite Fermions
Authors: Huang Haoyun , Hussain Waseem , Myers S. A. , Pfeiffer L. N. , West K. W. , Baldwin K. W. , Csáthy G. A. 
Published: February 2024

AbstractThe composite fermion theory opened a new chapter in understanding many-body correlations through the formation of emergent particles. The formation of two-flux and four-flux composite fermions is well established. While there are limited data linked to the formation of six-flux composite fermions, topological protection associated with them is conspicuously lacking. Here we report evidence for the formation of a quantized and gapped fractional quantum Hall state at the filling factor ν = 9/11, which we associate with the formation of six-flux composite fermions. Our result provides evidence for the most intricate composite fermion with six fluxes and expands the already diverse family of highly correlated topological phases with a new member that cannot be characterized by correlations present in other known members. Our observations pave the way towards the study of higher order correlations in the fractional quantum Hall regime.
Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission
Authors: Lage Lucia , Rodriguez-Perez Ana I. , Villar-Cheda Begoña , Labandeira-Garcia Jose L. , Dominguez-Meijide Antonio 
Published: February 2024

AbstractThe brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans. However, it is unknown whether AngII/AT1 overactivation affects α-synuclein aggregation and transmission. In vitro, AngII/AT1 activation increased α-synuclein aggregation in dopaminergic neurons and microglial cells, which was related to AngII-induced NADPH-oxidase activation and intracellular calcium raising. In mice, AngII/AT1 activation was involved in MPTP-induced increase in α-synuclein expression and aggregation, as they significantly decreased in mice treated with the AT1 blocker telmisartan and AT1 knockout mice. Cell co-cultures (transwells) revealed strong transmission of α-synuclein from dopaminergic neurons to astrocytes and microglia. AngII induced a higher α-synuclein uptake by microglial cells and an increase in the transfer of α-synuclein among astroglial cells. However, AngII did not increase the release of α-synuclein by neurons. The results further support brain RAS dysregulation as a major mechanism for the progression of Parkinson’s disease, and AT1 inhibition and RAS modulation as therapeutic targets.
Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder
Authors: Arakelyan Arsen , Avagyan Susanna , Kurnosov Aleksey , Mkrtchyan Tigran , Mkrtchyan Gohar , Zakharyan Roksana , Mayilyan Karine R. , Binder Hans 
Published: February 2024

AbstractThe molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span from embryonic life to advanced age. However, little is known about the early dynamics of gene expression in these disorders due to their relatively late manifestation. To address this, we conducted a secondary analysis of post-mortem prefrontal cortex datasets using bioinformatics and machine learning techniques to identify differentially expressed gene modules associated with aging and the diseases, determine their time-perturbation points, and assess enrichment with expression quantitative trait loci (eQTL) genes. Our findings revealed early, mid, and late deregulation of expression of functional gene modules involved in neurodevelopment, plasticity, homeostasis, and immune response. This supports the hypothesis that multiple hits throughout life contribute to disease manifestation rather than a single early-life event. Moreover, the time-perturbed functional gene modules were associated with genetic loci affecting gene expression, highlighting the role of genetic factors in gene expression dynamics and the development of disease phenotypes. Our findings emphasize the importance of investigating time-dependent perturbations in gene expression before the age of onset in elucidating the molecular mechanisms of psychiatric disorders.
Enhancing identification of nonaffective psychosis in register-based studies
Authors: Holm Minna , Suokas Kimmo , Liukko Emmi , Lindgren Maija , Näätänen Petri , Kärkkäinen Jukka , Salokangas Raimo K. R. , Suvisaari Jaana 
Published: February 2024

AbstractThe Finnish Quality of Psychosis Care Register assesses nonaffective psychosis (NAP) care, acknowledging treatment outside specialized psychiatric services. This approach, while providing a holistic view, raises concerns about diagnostic inaccuracies. Here, we studied situations where the register-based diagnosis might be inaccurate, and whether the first episode can be reliably identified using a 14-year wash-out period. People with first register-based NAP (ICD-10 F20-F29) between years 2010 and 2018 and without NAP diagnoses in 1996–2009 were identified from the Care Register for Health Care. A diagnosis of NAP was deemed unreliable before age 7, when dementia preceded NAP diagnosis, and when a NAP diagnosis had been assigned at admission or during psychiatric hospitalization but was not confirmed by discharge diagnosis. Despite a 14-year follow-back the first register diagnosis may miss the first treatment episode in older patients. Register-based studies on psychotic disorders should pay attention to exclusion criteria and to the definition of treatment onset.
MatKG: An autonomously generated knowledge graph in Material Science
Authors: Venugopal Vineeth , Olivetti Elsa 
Published: February 2024

AbstractIn this paper, we present MatKG, a knowledge graph in materials science that offers a repository of entities and relationships extracted from scientific literature. Using advanced natural language processing techniques, MatKG includes an array of entities, including materials, properties, applications, characterization and synthesis methods, descriptors, and symmetry phase labels. The graph is formulated based on statistical metrics, encompassing over 70,000 entities and 5.4 million unique triples. To enhance accessibility and utility, we have serialized MatKG in both CSV and RDF formats and made these, along with the code base, available to the research community. As the largest knowledge graph in materials science to date, MatKG provides structured organization of domain-specific data. Its deployment holds promise for various applications, including material discovery, recommendation systems, and advanced analytics.
Effects of different KRAS mutants and Ki67 expression on diagnosis and prognosis in lung adenocarcinoma
Authors: Wang Jun , Dong Liwen , Zheng Zhaowei , Zhu Zhen , Xie Baisheng , Xie Yue , Li Xiongwei , Chen Bing , Li Pan 
Published: February 2024

AbstractLung adenocarcinoma (LUAD) is a prevalent form of non-small cell lung cancer with a rising incidence in recent years. Understanding the mutation characteristics of LUAD is crucial for effective treatment and prediction of this disease. Among the various mutations observed in LUAD, KRAS mutations are particularly common. Different subtypes of KRAS mutations can activate the Ras signaling pathway to varying degrees, potentially influencing the pathogenesis and prognosis of LUAD. This study aims to investigate the relationship between different KRAS mutation subtypes and the pathogenesis and prognosis of LUAD. A total of 63 clinical samples of LUAD were collected for this study. The samples were analyzed using targeted gene sequencing panels to obtain sequencing data. To complement the dataset, additional clinical and sequencing data were obtained from TCGA and MSK. The analysis revealed significantly higher Ki67 immunohistochemical scores in patients with missense mutations compared to controls. Moreover, the expression level of KRAS was found to be significantly correlated with Ki67 expression. Enrichment analysis indicated that KRAS missense mutations activated the SWEET_LUNG_CANCER_KRAS_DN and CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 pathways. Additionally, patients with KRAS missense mutations and high Ki67 IHC scores exhibited significantly higher tumor mutational burden levels compared to other groups, which suggests they are more likely to be responsive to ICIs. Based on the data from MSK and TCGA, it was observed that patients with KRAS missense mutations had shorter survival compared to controls, and Ki67 expression level could more accurately predict patient prognosis. In conclusion, when utilizing KRAS mutations as biomarkers for the treatment and prediction of LUAD, it is important to consider the specific KRAS mutant subtypes and Ki67 expression levels. These findings contribute to a better understanding of LUAD and have implications for personalized therapeutic approaches in the management of this disease.
Erianin promotes endogenous neurogenesis in traumatic brain injury rats
Authors: Li Qingquan , Gan Xiaokui , Zhang Ming , Zhang Guangmin , Li Yingbin , Gao Liang 
Published: February 2024

AbstractThe objective of this study was to explore the positive influence and potential mechanism of Erianin on the recovery of brain cells following a traumatic brain injury (TBI). TBI rat models were prepared and treated with Erianin injection via tail vein. The assessment included evaluating the rats' levels of oxidative stress, inflammation, neuronal damage, mitochondrial damage, neuronal regeneration, transformation of pro-inflammatory microglial cells, activation status of the ERK signal pathway, and the functionality of their learning and memory. After administering Erianin, there was a suppression of oxidative stress, inflammation, nerve cell damage, and mitochondrial damage in the TBI rats. Additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in TBI rats, and simultaneous inhibition of the activation of the ERK1/c-Jun signal pathway. The findings suggest that Erianin has the potential to reduce oxidative stress and inflammatory reaction in rats with TBI, safeguard nerve cells against apoptosis, stimulate the growth of new neural cells, ultimately enhancing the cognitive abilities and memory function of the rats. The inhibition of the ERK signaling pathway could be closely associated with these effects.
Improving the risk management process in quality management systems of higher education
Authors: Bazaluk Oleg , Pavlychenko Artem , Yavorska Olena , Nesterova Olha , Tsopa Vitaliy , Cheberiachko Serhii , Deryugin Oleg , Lozynskyi Vasyl 
Published: February 2024

AbstractThe purpose of this paper is to improve the risk management process in the quality management system of higher education, taking into account the hazardous factors that increase the probability of occurrence and severity of consequences of undesirable events, as well as favorable factors that reduce the probability of occurrence and severity of consequences of hazardous events. The basis of risk management in the quality management systems of higher education institutions is the “Bowtie” method, which involves six main steps of identifying inconsistency, determining the impact of hazardous and favorable factors according to the impact group, ranking hazardous and favorable factors, calculating risk, substantiating precautionary measures and checking calculations. To rank hazardous and favorable factors, the authors used the “Decision Making Trial and Evaluation” method (hereinafter—DE-MATEL), which is based on paired comparison and decision-making tools based on graph theory. An improved process is proposed for risk assessment, which differs from the known ones by the presence of the identification of the cause-and-effect relationship “hazard (inconsistency)-hazardous event-consequences”, identification of hazardous and favorable factors of the internal and external environment that affect the probability and/or the degree of severity of a hazardous event—the appearance of an inconsistency, which is carried out after the inconsistency has been determined; determination of causal hazardous and favorable factors by an acceptable method. Registers of inconsistencies (hazards), hazardous and favorable factors have been developed and proposed based on the requirements for accreditation of educational programs and the international standard ISO 9001:2015, which will allow, based on a risk-oriented approach, to provide a basis for setting the goals of a higher education institution under martial law in order to guarantee effective implementation of the mission and strategy. They are proposed for decision-making in the quality management systems of educational organizations on the substantiation of precautionary or corrective measures based on ranking the risks from identified inconsistencies, which are determined taking into account the impact of the entire set of identified significant hazardous and favorable factors. The value of this paper is to improve the quality risk management process in educational organizations, taking into account the impact of hazardous and favorable factors, and to develop an appropriate step-by-step algorithm of actions and a risk assessment form.
Individuals departing non-breeding areas early achieve earlier breeding and higher breeding success
Authors: Bell Fraser , Ouwehand Janne , Both Christiaan , Briedis Martins , Lisovski Simeon , Wang Xuelai , Bearhop Stuart , Burgess Malcolm 
Published: February 2024

AbstractConditions experienced by an individual during migration have the potential to shape migratory tactic and in turn fitness. For large birds, environmental conditions encountered during migration have been linked with survival and subsequent reproductive output, but this is less known for smaller birds, hindering our understanding of mechanisms driving population change. By combining breeding and tracking data from 62 pied flycatchers (Ficedula hypoleuca) representing two breeding populations collected over 2016-2020, we determine how variation in migration phenology and tactic among individuals affects subsequent breeding. Departure date from West African non-breeding areas to European breeding grounds was highly variable among individuals and had a strong influence on migration tactic. Early departing individuals had longer spring migrations which included longer staging duration yet arrived at breeding sites and initiated breeding earlier than later departing individuals. Individuals with longer duration spring migrations and early arrival at breeding sites had larger clutches, and for males higher fledging success. We suggest that for pied flycatchers, individual carry-over effects may act through departure phenology from West Africa, and the associated spring migration duration, to influence reproduction. While our results confirm that departure date from non-breeding areas can be associated with breeding success in migratory passerines, we identify spring staging duration as a key component of this process.
In vitro SELEX and application of an African swine fever virus (ASFV) p30 protein specific aptamer
Authors: Hu Changchun , Li Shuo , Zhou Jie , Wei Dan , Liu Xueying , Chen Zhu , Peng Hongquan , Liu Xun , Deng Yan 
Published: February 2024

AbstractThe African swine fever virus (ASFV) has caused severe economic losses in the pig industry. To monitor ASFV spread, the p30 protein has been identified as an ideal infection marker due to its early and long-term expression during the ASFV infection period. Timely monitoring of ASFV p30 enables the detection of ASFV infection and assessment of disease progression. Aptamers are an outstanding substitute for antibodies to develop an efficient tool for ASFV p30 protein detection. In this study, a series of aptamer candidates were screened by in vitro magnetic bead-based systematic evolution of ligands by exponential enrichment (MB-SELEX). An aptamer (Atc-20) finally showed high specificity and affinity (Kd = 140 ± 10 pM) against ASFV p30 protein after truncation and affinity assessment. Furthermore, an aptamer/antibody heterogeneous sandwich detection assay was designed based on Atc20, achieving a linear detection of ASFV p30 ranging from 8 to 125 ng/ml and a detection limit (LOD) of 0.61 ng/ml. This assay showed good analytical performances and effectively detected p30 protein in diluted serum samples, presenting promising potential for the development of ASFV biosensors.
Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection
Authors: Thathapudi Neethi C. , Callai-Silva Natalia , Malhotra Kamal , Basu Sankar , Aghajanzadeh-Kiyaseh Mozhgan , Zamani-Roudbaraki Mostafa , Groleau Marc , Lombard-Vadnais Félix , Lesage Sylvie , Griffith May 
Published: February 2024

AbstractCorneal HSV-1 infections are a leading cause of infectious blindness globally by triggering tissue damage due to the intense inflammation. HSV-1 infections are treated mainly with antiviral drugs that clear the infections but are inefficient as prophylactics. The body produces innate cationic host defence peptides (cHDP), such as the cathelicidin LL37. Various epithelia, including the corneal epithelium, express LL37. cHDPs can cause disintegration of pathogen membranes, stimulate chemokine production, and attract immune cells. Here, we selected GF17, a peptide containing the LL37 fragment with bioactivity but with minimal cytotoxicity, and added two cell-penetrating amino acids to enhance its activity. The resulting GF19 was relatively cell-friendly, inducing only partial activation of antigen presenting immune cells in vitro. We showed that HSV-1 spreads by tunneling nanotubes in cultured human corneal epithelial cells. GF19 given before infection was able to block infection, most likely by blocking viral entry. When cells were sequentially exposed to viruses and GF19, the infection was attenuated but not arrested, supporting the contention that the GF19 mode of action was to block viral entry. Encapsulation into silica nanoparticles allowed a more sustained release of GF19, enhancing its activity. GF19 is most likely suitable as a prevention rather than a virucidal treatment.
Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant
Authors: Mahgoub Samar M. , Essam Doaa , Eldin Zienab E. , Moaty S. A. Abdel , Shehata Mohamed R. , Farghali Ahmed , Abdalla Saif Elden B. , Othman Sarah I. , Allam Ahmed A. , El-Ela Fatma I. Abo , Mahmoud Rehab 
Published: February 2024

AbstractFluoxetine (FLX) is one of the most persistent pharmaceuticals found in wastewater due to increased use of antidepressant drugs in recent decades. In this study, a nanocomposite of ternary ZnCoAl layered double hydroxide supported on activated carbon (LAC) was used as an adsorbent for FLX in wastewater effluents. The nanocomposite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis (BET). The adsorption investigations showed that the maximum removal capacity was achieved at pH 10, with a 0.1 g/L adsorbent dose, 50 mL volume of solution, and at a temperature of 25 °C. The FLX adsorption process followed the Langmuir–Freundlich model with a maximum adsorption capacity of 450.92 mg/g at FLX concentration of 50 µg/mL. Density functional theory (DFT) computations were used to study the adsorption mechanism of FLX and its protonated species. The safety and toxicity of the nanocomposite formed from the adsorption of FLX onto LAC (FLX-LAC) was investigated in male albino rats. Acute toxicity was evaluated using probit analysis after 2, 6, and 24 h to determine LD50 and LD100 values in a rat model. The FLX-LAC (20 mg/kg) significantly increased and lengthened the sleep time of the rats, which is important, especially with commonly used antidepressants, compared to the pure standard FLX (7 mg/kg), regular thiopental sodium medicine (30 mg/kg), and LAC alone (9 mg/kg). This study demonstrated the safety and longer sleeping duration in insomniac patients after single-dose therapy with FLX-LAC. Selective serotonin reuptake inhibitors (SSRIs) like FLX were found to have decreased side effects and were considered the first-line mood disorder therapies.
Combined substituent number utilized machine learning for the development of antimicrobial agent
Authors: Yamauchi Keitaro , Nakatsuji Hirotaka , Kamishima Takaaki , Koseki Yoshitaka , Kubo Masaki , Kasai Hitoshi 
Published: February 2024

AbstractThe utilization of machine learning has a potential to improve the environment of the development of antimicrobial agents. For practical use of machine learning, it is important that the conversion of molecules information to an appropriate descriptor because too informative descriptor requires enormous computation time and experiments for gathering data, whereas a less informative descriptor has problems in validity. In this study, we utilized a descriptor only focused on substituent. The type and the position of substituents on the molecules that have a 4-quinolone structure (11,879 compounds) were converted to the combined substituent number (CSN). While the CSN does not include information on the detailed structure, physical properties, and quantum chemistry of molecules, the prediction model constructed by machine learning of CSN indicated a sufficient coefficient of determination (0.719 for the training dataset and 0.519 for the validation dataset). In addition, this CSN can easily construct the unknown molecules library which has a relatively consistent structure by recombination of substituents (32,079,318 compounds) and screening of them. The validity of the prediction model was also confirmed by growth inhibition experiments for E. coli using the model-suggested molecules and commercially available antimicrobial agents.