bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative readability of information on different treatment options for breast cancer, based on WeChat public accounts
Authors: Li Bingyan , Liu Jia , Zhang Yuxi , Yang Wenjuan , Liu Min , Xie Lunfang 
Published: January 2025

Objective
To evaluate and compare the readability of information on different treatment options for breast cancer from WeChat public accounts, propose targeted improvement strategies based on the evaluation of the results of the various treatment options, and provide a reference for producers of WeChat public accounts from which to write highly readable information regarding breast cancer treatment options.

Methods
With “breast cancer” as keywords in April 2021, searches were implemented on Sogou WeChat website (https://weixin.sogou.com/) and WeChat mobile app. The selected WPAs were aimed to provided breast cancer health information, and the four latest articles of each WPA were included in the evaluation. Two independent observers assessed the readability of the articles through the Suitability Assessment of Materials (SAM) tool, and compared the readability of information on different treatment options, i.e., surgical treatment, medical treatment, complementary and alternative medicine (CAM), and comprehensive treatment.

Results
A total of 136 articles on different types of breast cancer treatments from 37 WeChat public accounts were included in the present study. The median SAM score was 50 (IQR, 41–60). In terms of treatment options, the readability of articles in the CAM category scored higher in the content 75 (IQR, 63–81), learning stimulation and motivation 75 (IQR, 50–83) and cultural appropriateness 75 (IQR, 75–75) categories than in the medical and surgical treatment categories (P < 0.05). Additionally, the readability of articles in the CAM category scored higher in the cultural appropriateness 75 (IQR, 75–75) category than those for comprehensive and medical treatment (P < 0.05).

Conclusions
The overall readability of information on breast cancer treatment options in WeChat public accounts was in the lower portion of the “adequate” level. The readability of articles on medical treatment options is poor, especially on clinical trial articles, which could be improved in terms of content, graphics, learning stimulation, and motivation to make them more suitable for public reading.
Association of chronic kidney disease with acute clinical outcomes and hospitalization costs of cancer resection
Authors: Sakowitz Sara , Bakhtiyar Syed Shahyan , Mallick Saad , Vadlakonda Amulya , Oxyzolou Ifigenia , Ali Konmal , Chervu Nikhil , Benharash Peyman 
Published: January 2025

Purpose
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have been noted to face increased cancer incidence. Yet, the impact of concomitant renal dysfunction on acute outcomes following elective surgery for cancer remains to be elucidated.

Methods
All adult hospitalizations entailing elective resection for lung, esophageal, gastric, pancreatic, hepatic, or colon cancer were identified in the 2016–2020 National Inpatient Sample. Based on stage of renal dysfunction, CKD patients were sub-classified as CKD1-3, CKD4-5, or ESRD (others: Non-CKD). Multivariable regression models were developed to assess the association of comorbid CKD/ESRD with in-hospital mortality, perioperative complications, and resource utilization.

Results
Of ~515,145 patients, 32,195 (6.2%) had CKD (5.1% CKD1-3, 0.7% CKD4-5, 0.5% ESRD). The incidence of CKD among patients undergoing cancer resection increased from 5.3% in 2016 to 7.3% in 2020 (P<0.001). Following risk adjustment, CKD1-3 and CKD4-5 remained linked with similar likelihood of mortality and hospitalization costs, but greater need for blood transfusion (CKD1-3 AOR 1.21, CI 1.09–1.35; CKD4-5 AOR 1.73 CI 1.38–2.18). CKD4-5 was also associated with greater odds of infection (AOR 1.88, CI 1.34–2.62) and respiratory sequelae (AOR 1.36, CI 1.05–1.77). Further, ESRD was linked with greater odds of in-hospital mortality (AOR 2.74, CI 1.69–4.45), infection (AOR 2.31, CI 1.62–3.30) and respiratory complications (AOR 1.72, CI 1.31–2.26), as well as greater resource utilization, relative to Non-CKD.

Conclusion
Comorbid renal dysfunction was linked with inferior clinical and financial outcomes following elective cancer resection. Future work is needed to develop optimal management strategies and recovery pathways for this complex cohort.
Assessing a bundle of peer counseling, mobile phone messages, and mama kits in promoting timely initiation of and exclusive breastfeeding in Uganda: A cluster randomized controlled study
Authors: Mukunya David , Tumwine James K. , Ndeezi Grace , Musaba Milton W. , Tongun Justin Bruno , Tumuhamye Josephine , Napyo Agnes , Oguttu Faith , Amanya Daphine , Odongkara Beatrice , Achora Vincentina , Tylleskar Thorkild , Nankabirwa Victoria 
Published: January 2025

Background
Timely initiation of and exclusive breastfeeding have been recommended as key interventions to enable countries to attain the sustainable development target of reducing neonatal mortality to no more than 12 deaths per 1000 live births and to reduce mortality of children under 5 years to no more than 25 deaths per 1000 live births.

Methods
We conducted a cluster randomized controlled trial with the main objective to assess the effect of an integrated package consisting of: peer counseling, mobile phone messages, and mama kits on promoting health facility births between January 2018 and February 2019, in Lira district, Northern Uganda. In this article, we assessed the effect of the intervention on our two secondary objectives: timely initiation of and exclusivity of breastfeeding. We used a generalized estimation equation of the Poisson family, with a log or identity link, taking clustering into account to estimate prevalence ratios and prevalence differences.

Results
A total of 64% (594/926) of participants in the intervention arm initiated breastfeeding within the first hour after birth compared to 60% (493/829) in the control arm. The proportion of participants in the intervention arm that initiated breastfeeding within the first hour of life did not significantly differ from that in the control arm [Prevalence Ratio (PR) 1.08 (0.97 to 1.21)] and [Prevalence Difference (PD) 0.05 (-0.02 to 0.12)]. When we restricted the analysis to only mothers who decided on when to breastfeed, there was some evidence of intervention effectiveness [PR 1.20, 95% CI (0.99–1.5)]. In the intervention arm, 89% (804/904) of participants exclusively breastfed their infants in the first month of life compared to 81% (656/813) in the control arm. Participants in the intervention arm were 10% more likely to have exclusively breastfed in the preceding 24 hours compared to mothers in the control arm [PR 1.10 (1.04 to 1.17)] and [PD 0.08 (0.04 to 0.13)], and 16% more likely to have exclusively breastfed since birth compared to mothers in the control arm [PR 1.16 (1.03 to 1.30)] and [PD 0.12 (0.03 to 0.20].

Conclusion
The intervention improved the proportion of mothers who practiced exclusive breastfeeding in the first month of life, but did not increase the proportion of mothers who initiated breastfeeding in the first hour of life. Future breastfeeding promotion interventions should consider including a health facility component and improving maternal autonomy to promote timely initiation of breastfeeding.
Determining patient activity goals and their fulfillment following total knee arthroplasty: Findings from the prospective, observational SuPeR Knee study
Authors: Ribbons Karen , Payne Kristy , Ditton Elizabeth , Johnson Sarah , Wills Adrian , Walker Frederick Rohan , Pollack Michael , Nilsson Michael 
Published: January 2025

Background
Dissatisfaction with Total Knee Arthroplasty (TKA) surgical outcomes remains between 10–20% and is associated with higher levels of societal costs. Expectations regarding post-surgical outcomes is considered as one of the major factors influencing satisfaction, however, there are no standardised methods for assessing patient’s expectations regarding activities to be achieved following surgery.

Objectives
The aims of this study were to identify patient expectations relating to activities of importance following TKA and to describe goal fulfillment at 3 months post-TKA. We hypothesised that activity expectation fulfillment would be associated with overall satisfaction with TKA outcomes.

Methods
This study comprised secondary data analysis of findings from the SuPeR Knee study. Using conventional content analysis, a classification system of activities specific to our TKA patient cohort was created. At 3 months following TKA, patients rated satisfaction with fulfilling activity goals and pain attenuation. The average level of satisfaction achieved was used as our measure of goal fulfillment. Overall satisfaction of the outcomes of surgery was rated using a 5-point Likert scale and the association between goal fulfillment and overall surgery satisfaction was compared by Spearman’s rank correlation.

Results
Data were collected from 861 TKA patients. Recreation and sporting pursuits were found to be important activity types (43% of all activities). At 3 months after surgery, less impactful activities were more commonly satisfied (67%), including domestic and vocational activities, low impact hobbies and leisure activities. Goal fulfillment and improvement in knee pain were both significantly positively correlated to, and significant predictors of, overall patient satisfaction (p≤0.001).

Conclusions
Our Australian cohort of TKA patients have a range of expectations for undertaking high-impact activities after surgery. However, at 3 months after surgery, higher rates of satisfaction were attained for lower-impact activities. Our findings support the importance of identifying activity expectations for each patient and that fulfillment of these goals contributes to overall satisfaction with the outcomes of TKA.
Efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis: A systematic review and meta-analysis
Authors: Wang Li , Chen Su-Fang , Huang Xi-Wei , Wu Zhi-Yang , Zhang Qing-Mei 
Published: January 2025

Purpose
To systematically evaluate the efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis, and to provide guidance for its clinical treatment.

Methods
We conducted a search of The Cochrane Library, PubMed, EMbase, and Web of Science databases to retrieve randomized controlled trials (RCTs) on the use of creatine phosphate sodium (CPS) in the treatment of viral myocarditis. The search was conducted up to April 2024. After screening the literature, extracting data, and evaluating the risk of bias in the included studies, we performed a meta-analysis using RevMan 5.4 and Stata17.0 statistical software.

Results
A total of 104 articles were retrieved, and 9 articles with a combined total of 1,116 patients were ultimately included in the meta-analysis. The results of the meta-analysis indicated that the overall efficacy rate in the phosphocreatine sodium treatment group was higher than that in the control group [RR = 1.22, 95%CI (1.15, 1.28), P<0.00001]. Furthermore, post-treatment levels of cardiac troponin I [MD = 0.1, 95%CI (0.07, 0.13), P<0.00001] and creatine kinase isoenzyme [MD = 9.43, 95%CI (7.04,11 .82), P<0 .00001] in the phosphocreatine treatment group were lower compared to those in the control group; both differences between groups were statistically significant. Additionally, there was no significant difference observed in adverse reaction incidence between the phosphocreatine sodium treatment group and conventional treatment group [RR = 1 .07, 95% CI (0 .68, 1 .67), P = O .77].

Conclusion
Creatine phosphate sodium treatment can significantly improve the therapeutic effect of patients with viral myocarditis, and can reduce the levels of cTnI and CK-MB. Compared with conventional treatment, it has good safety.
The effects of preoperative glenohumeral osteoarthritis on rotator cuff repair: A systematic review and meta-analysis
Authors: Fang Sen , Liang Junwen , Yang Xudong , Daoji Cairang , Nian Zhixuan , Li Mingchun , Jiang Jin , Yun Xiangdong 
Published: January 2025

Purpose
This meta-analysis was carried out to evaluate the clinical effectiveness of rotator cuff repair surgery in treating rotator cuff tears in individuals with mild glenohumeral osteoarthritis (GHOA).

Methods
A computer-based search was conducted across multiple databases including PubMed, Embase, Web of Science, and Cochrane Library using the keywords "Shoulder Joints", "Osteoarthrosis", and "rotator cuff". Only studies focusing on patients with GHOA who underwent rotator cuff repair were considered for inclusion. The pertinent data was extracted and assessed for heterogeneity.

Results
A total of 5 studies involving 924 patients were included in the meta-analysis. The treatment outcomes of patients with rotator cuff tears accompanied by mild GHOA and those with simple rotator cuff tears after rotator cuff repair were comparable in terms of retear(OR: 1.24; 95% CI 0.82–1.89; P = 0.31). The postoperative functional scores: the VAS score (MD: 0.14; 95% CI -0.19–0.47; P = 0.41)、ASES score (MD: -0.33; 95% CI -1.64–0.99)were similar between the two groups. Subgroup analysis of rotator cuff tears(small to moderate, MD: 0.85; 95%CI -0.65–2.39; p = 0.28; large to massive, MD: -1.94; 95% CI -8.45–4.58; P = 0.56), showed no difference in postoperative ASES scores between the two groups. Constant score (MD:-3.20; 95% CI -6.33–0.08; P = 0.04), external rotation (ER) in Range of motion (ROM) (MD: -4.42; 95% CI -6.72–2.13; P = 0.0002) and forward flexion (FF) in ROM(MD: -4.22; 95% CI -8.28–0.15; P = 0.04) were superior in patients with simple rotator cuff tears compared to those with rotator cuff tears accompanied by GHOA.

Conclusion
Patients with rotator cuff tears and mild GHOA can achieve shoulder joint restoration after shoulder cuff repair surgery, and there is only a certain difference in postoperative Constant Score and ROM between these two groups.

Trial registration
PROSPERO registration CRD42024565212.
Physical activity and metabolic syndrome in primary care patients in Spain
Authors: Micó-Pérez Rafael Manuel , Hernández Segura Natalia , Martín-Sánchez Vicente , Barquilla-García Alfonso , Velilla-Zancada Sonsoles M. , Polo-García José , Prieto-Díaz Miguel Ángel , Pallares-Carratala Vicente , Segura-Fragoso Antonio , Ginel-Mendoza Leovigildo , Cinza-Sanjurjo Sergio 
Published: January 2025

Purpose
To determine the relationship between self-reported physical activity and the components of premorbid metabolic syndrome in patients treated in primary care according to sex.

Methods
Cross-sectional descriptive study conducted on a sample of 2,359 patients without cardiovascular disease or diabetes, included in the cohort of the IBERICAN study. Using ANOVA models and adjusting for age, economic status, employment situation, level of education, adherence to a Mediterranean diet, tobacco use and alcohol consumption, we estimated the association of the variables blood pressure, triglycerides, HDL cholesterol, blood glucose and waist circumference with the self-reported level of physical activity (sedentary, moderate, high, very high). The analyses were performed stratifying by sex.

Results
A total of 854 men and 1,505 women with no identified diseases were included. Women were more sedentary than men (p<0.004; OR = 1,35; IC95% = 1,10–1,65) and presented lower values in all the components of the metabolic syndrome, except for HDL-cholesterol, which was higher (p<0.001). The adjusted ANOVA model shows that diastolic blood pressure, triglycerides, fasting blood glucose, and waist circumference were significantly lower the higher the level of physical activity in both men and women (p<0.05).

Conclusions
Patients served in primary care clinics without diabetes or cardiovascular disease and with high levels of physical activity showed better metabolic syndrome profiles. Given that women are more sedentary, gender approaches are needed in the promotion of physical activity to prevent metabolic syndrome and cardiovascular disease.
Multicenter randomized double-blind placebo-controlled crossover study of the effect of prolonged noisy galvanic vestibular stimulation on posture or gait in vestibulopathy
Authors: Fujimoto Chisato , Kawahara Takuya , Kikkawa Yayoi S. , Kinoshita Makoto , Kamogashira Teru , Oka Mineko , Uranaka Tsukasa , Egami Naoya , Ichijo Kentaro , Kabaya Kayoko , Katsumi Sachiyo , Takashima Ikumi , Yamamoto Yoshiharu , Yagi Masato , Yamasoba Tatsuya , Iwasaki Shinichi 
Published: January 2025

Objective
This multicenter, randomized, double-blind, placebo-controlled, crossover trial aimed to evaluate whether prolonged noisy galvanic vestibular stimulation improves body balance in patients with vestibulopathy.

Materials and methods
This trial was registered in the Japan Pharmaceutical Information Center Clinical Trials Information registry (jRCT1080224083). Subjects were 20- to 85-year-old patients who had been unsteady for more than one year and whose symptoms had persisted despite more than six months of rehabilitation. Enrolled subjects were randomly assigned to one of two groups; one group received the optimal intensity of noisy galvanic vestibular stimulation first and then the placebo 14 days later, the other was evaluated in the reverse order. The primary outcome was the difference of the mean percent change from the baseline in the velocity of center of pressure during 3 h of stimulation between the noisy galvanic vestibular stimulation and placebo periods. This was analyzed with the mixed effects model.

Results
Forty-two subjects were enrolled. The mean percent change in the velocity during stimulation for 3 h was -9.3% (SD 19.9%) for noisy galvanic vestibular stimulation and -12.6% (SD 15.0%) for placebo. No significant effects of noisy galvanic vestibular stimulation over placebo were found for velocity in the least-squares means of the difference [3.1% (95% CI -0.2 to 6.4, p = 0.066)].

Conclusion
Prolonged noisy galvanic vestibular stimulation did not significantly improve body balance in patients with poorly-compensated vestibulopathy.
BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study
Authors: Xu Wendi , Chen Zhe , Jiang Yuhong , Zeng Hongbo , He Nan , Liu Ziyi , Zhou Meirong 
Published: January 2025

Background
Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, the association between glyphosate and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims to explore the effect of glyphosate exposure on ASCVD.

Methods
This study involved 1,602 participants and employed various statistical techniques, such as multivariable logistic regression, linear fitting, mediation analysis, subgroup analysis, and sensitivity analysis, to elucidate the association between glyphosate exposure and cardiovascular diseases.

Results
Compared with the low level of glyphosate exposure, the risk of ASCVD increased significantly with high level of glyphosate exposure (OR = 2.05, 95%CI = 1.17–3.58, p<0.05, p for trend<0.05), which showed a linear upward trend. Further analysis found that exposure to high levels of glyphosate and angina pectoris (OR = 2.84, 95%CI = 1.00–8.04, p<0.05, p for trend<0.05), coronary heart disease (OR = 3.76, 95%CI = 1.80–7.83, p<0.01, p for trend<0.05), heart attack (OR = 2.65, 95%CI = 1.35–5.23, p<0.01, p for trend = 0.09) were associated. Mediating analysis found that BMI mediated the association between glyphosate exposure and ASCVD, with an indirect effect of 0.002405(95%CI: 0.000182–0.01, p = 0.02) and a direct effect of 0.039336(95%CI: 0.000391–0.09), total effect of 0.041741(95%CI: 0.002112–0.10).

Conclusion
Increased exposure to glyphosate is associated with an increased risk of ASCVD, and BMI plays a mediating role in this association. In addition, glyphosate exposure is associated with a higher risk of angina, coronary heart disease, and heart attack.
Low-profile double plating versus conventional single plating in midshaft clavicle fractures: A retrospective study and initial experience with this novel technique
Authors: Lecoultre Yannic , van de Wall Bryan , Link Bjoern-Christian , Kik Charlotte , Babst Reto , Beeres Frank 
Published: January 2025

Background
Low-profile double plating seems a viable alternative to conventional single plating for fixation of midshaft clavicle fractures. This study aims to compare the two techniques regarding healing, complications, and removal rate.

Methods
This retrospective cohort study included all patients >16 years that underwent plate fixation for midshaft clavicle fractures between 2020 and 2022 at one trauma-center. Exclusion criteria encompassed pathological or open fractures, refractures and delayed presentation or treatment more than 14 days after the accident. Patients were categorized into two treatment groups: Single plating (Synthes 3.5mm LCP superior / anterior or Synthes 2.7mm VA-LCP superior) and low-profile double plating (2.0 superior combined with either 2.4 or 2.7mm anterior mini-plate). Treatment groups were compared regarding healing, complications, and removal rate.

Results
A total of 99 patients were included: 74 in the single plating and 25 in the double plating group. Implant failures within the first three months were comparable in both groups (4.0% double plating versus 2.7% single, p = 0.744, of which one was caused by infection). Low-profile double plating had a significantly lower operation duration (95 versus 111 minutes, p = 0.019). Long-term follow-up data was available in 60 patients in the single plating and 20 in the double plating group. The need for reintervention was significantly lower in the double plating group (n = 5, 25.0% vs. n = 31, 51.7%, p = 0.038). These reinterventions were predominantly caused by implant irritation in both groups (n = 4, 20% double plating versus n = 29, 48.3% single plating, p = 0.026). All fractures healed in both groups.

Conclusion
Low-profile double plating attains comparable healing rates as single plating and has a significantly lower risk for re-intervention as well as a shorter operation duration. The lower reintervention rate is mainly explained by a lower incidence of implant irritation in the double plating group.
Non-homogeneous BVPs for second-order symmetric Hamiltonian systems
Authors: Chen Yingying , Dong Yujun , Wang Baiqian 
Published: January 2025

Abstract
By making use of Bolle’s method, we show that the following problem has infinitely many solutions:

x

¨

+

V

′

(

x

)

=

0
,

x

(

0

)

cos
α
−

x

˙

(

0

)

sin
α

=

x

0

,

x

(

1

)

cos
β
−

x

˙

(

1

)

sin
β

=

x

1

,

\begin{array}{rcl}\ddot{x}+{V}^{^{\prime} }\left(x)& =& 0,\\ x\left(0)\cos \alpha -\dot{x}\left(0)\sin \alpha & =& {x}_{0},\\ x\left(1)\cos \beta -\dot{x}\left(1)\sin \beta & =& {x}_{1},\end{array}

where

α
,
β
∈

(

0
,
π

)

x

0

,

x

1

∈

R

n

\alpha ,\beta \in \left(0,\pi ){x}_{0},{x}_{1}\in {{\rm{R}}}^{n}

are given and

V
∈

C

2

(

R

n

,
R

)

V\in {C}^{2}\left({{\rm{R}}}^{n},{\rm{R}})

is even and is super-quadratic at infinity.