bluuebunny/crossref_metadata_2025_split huggingface dataset:
An In-depth Analysis of the Adverse Effects of Ionizing Radiation Exposure
on Cardiac Catheterization Staffs
Authors: Alvandi Maryam , Javid Roozbeh Narimani , Shaghaghi Zahra , Farzipour Soghra , Nosrati Sahar 
Published: February 2024

Abstract:
Diagnostic and interventional angiograms are instrumental in the multidisciplinary
approach to CAD management, enabling accurate diagnosis and effective targeted treatments
that significantly enhance patient care and cardiovascular outcomes. However, cath lab staff,
including interventional cardiologists, is consistently exposed to ionizing radiation, which poses
inherent health risks. Radiation exposure in the cath lab primarily results from the use of fluoroscopy
and cineangiography during diagnostic and interventional procedures. Understanding
these risks and implementing effective radiation protection measurements are imperative to ensure
the well-being of healthcare professionals while delivering high-quality cardiac care. Prolonged
and repeated exposure can lead to both deterministic and stochastic effects. Deterministic
effects, such as skin erythema and tissue damage, are more likely to occur at high radiation
doses. Interventional cardiologists and staff may experience these effects when safety measures
are not rigorously followed. In fact, while ionizing radiation is essential in the practice of radiation
cardiology ward, cath lab staff faces inherent risks from radiation exposure. Stochastic effects,
on the other hand, are characterized by a probabilistic relationship between radiation exposure
and the likelihood of harm. These effects include the increased risk of cancer, particularly
for those with long-term exposure. Interventional cardiologists, due to their frequent presence
in the cath lab, face a higher lifetime cumulative radiation dose, potentially elevating their cancer
risk. Protective measures, including the use of lead aprons, thyroid shields, and radiation
monitoring devices, play a crucial role in reducing radiation exposure for cath lab personnel.
Adherence to strict dose optimization protocols, such as minimizing fluoroscopy time and maximizing
distance from the radiation source, is also essential in mitigating these risks. Ongoing
research and advancements in radiation safety technology are essential in further for minimizing
the adverse effects of ionizing radiation in the cath lab.
Exploring the Molecular Mechanisms of Acorus tatarinowii and Ginseng in the
Treatment of Autism Spectrum Disorder Based on Network Pharmacology
and Molecular Docking
Authors: Chen Weijun , Wu Yan , Hu Yuan , Zhu Liuyan , Wu Lingling , Bai Guannan , Zou Chaochun 
Published: February 2024

Background:
Acorus tatarinowii and Ginseng (AT-G) are traditional Chinese herbal
medicines extensively utilized in neurological disorders treatment. However, due to the complex
components of AT-G and the pathological mechanism of ASD, the mechanisms involved in the
treatment of ASD with AT-G remain elusive.

Objective:
We explored AT-G potential mechanisms in ASD treatment.

Methods:
We used the network pharmacology approach to evaluate the beneficial effects of AT-G
for ASD, including obtaining the active components of AT-G by the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform, detecting the potential targets genes associated
with ASD of Genecards and DisGenet databases, network analysis, and virtual docking.

Results:
A total of 26 AT-G components, 130 AT-G targets, and 806 ASD-related genes were
identified using the bioinformatics analysis tool, including TCMSP, Genecards, and DisGenet. In
the intersection of potential pharmacodynamic targets of AT-G and genes associated with ASD,
we identified 41 potential common targets. Then, GO enrichment analysis revealed that the common targets were mainly associated with biological processes (i.e., positive regulation of nitric
oxide biosynthetic process, response to xenobiotic stimulus), cellular components (i.e., the presynaptic membrane and postsynaptic membrane), and molecular functions (i.e., RNA polymerase
II transcription factor activity, identical protein binding). KEGG pathway analysis found that the
common targets were enriched in chemical carcinogenesis - receptor activation, fluid shear stress
and atherosclerosis, lipid and atherosclerosis, and IL-17 signaling pathways. In addition, 10 core
targets were screened from the PPI network (e.g., TNF, AKT1, PTGS2, MMP, PPARG, IFNG,
NOS2, TGFB1, and CASP1). Molecular docking revealed that the common component
kaempferol has a high affinity for the four primary disease targets.

Conclusion:
Our results facilitated the in-depth development of AT-G and their individual components and provided a reference for clinical practice
Standardization and Evaluation of Triphala Juice and Quantification of
Gallic Acid as a Biomarker by Analytical Techniques
Authors: Ahire Tejas , Gosavi Seema , Pawar Sarita , Kulkarni Aditi 
Published: February 2024

Background::
Standardization of Triphala Juice was performed by using the WHO
Guidelines. The Parameters included Preliminary Analysis, Phytochemical Identification, Heavy
Metal Estimation, etc. A new simple, specific, precise and accurate UV Spectrophotometric,
High-Performance Liquid.

Methods::
Chromatography and High-Performance Thin Layer Chromatography method has been
developed for the Estimation of Gallic Acid in pure form.

:
The UV- Spectrophotometric method was developed using Schimadzu 1800 UV - Visible spectrophotometer
using methanol as a solvent. The method was shown to be linear, with a detection
wavelength of 273 nm for Gallic Acid.

:
The separation was achieved on the Schimadzu Prominence-I RP-HPLC and the column used was
C18 column using mobile phase consisting of mixture of Methanol: 0.1% OPA (50:50). The
detection was carried out at 280 nm with a flow rate of 0.7 ml/min. The retention time for Gallic
Acid was found 3.89 minutes. The calibration curve was found linear (r2 = 0.999) for RP- HPLC
method.

:
The HPTLC method was developed using Aetron Sprayline instrument, Methanol as solvent and
mobile phase consisting of Toluene: Ethyl Acetate: Formic Acid: Methanol (3:3:0.9:0.2).
The method was found linear and the wavelength of detection for Gallic Acid was 254 nm,
respectively.

:
The percentage recoveries for both methods were found in the 98.0- 102.0% range.

:
Results: The methods were validated in accordance with International Conference on harmonization
acceptance criteria for specificity, linearity, precision, accuracy, robustness and system suitability.
The excipients did not interfere in the determination of Gallic acid in Triphala Juice.

Conclusion::
The suggested approach was effectively implemented for the quantitative determination
of gallic acid in Triphala juice, which would aid in quality control.
Exploring the Fascinating Diversity, Medicinal Significance, and Ecological
Adaptation of Ceropegia bulbosa Roxb.: A Comprehensive Review
Authors: Chothani Daya L. , Trivedi Udit , Patel Jigneshkumar I. 
Published: February 2024

Background:
A large variety of unknown plants has tremendous usefulness in improving
human beings from a medicinal, nutritional, and dietary perspective. Ceropegia bulbosa
species are threatened plant species by (the International Union for Conservation of Nature)
IUCN which have significant medicinal value. Ceropegia bulbosa species are generally found in
various regions of India. GC-MS data of different extracts such as Ethanol, Methanol, Acetone,
Ethyl acetate, and chloroform show the biologically active compounds that exhibit various biological
actions. Bioactive compounds reported in Ceropegia bulbosa are Tetradecanoic acid,
Pentadecanoic acid, Heptadecanoic acid, Octadecanoic acid, Ergost-5-en-3-ol, (3 beta, 24R)-
Stigmast-5-en-3-ol, Tetracontane, Squalene, Beta-stigmasterol.

Discussion:
Traditionally, leaves, tubers, stems, and flowers are used in the treatment of several
diseases. Also, various tribal and rural regions have a different identity of Ceropegia bulbosa.
Hence, it has the same ethnopharmacological remedies like the decoction of tubers used to treat
dysentery and diarrhea and remove kidney stones. Pulp of leaves used for deafness.

Conclusion:
Traditionally, it is used as an anti-urolithic, dysentery and diarrhea, deafness, and
fertility enhancer. The plant is reported as anti-urolithic, anti-fungal, anti-oxidant, immunomodulatory,
malnutrition, and Balya karma. Ceropegia bulbosa is reported to contain Tetradecanoic
acid, Pentadecanoic acid, Heptadecanoic acid, Octadecanoic acid, Ergost-5-en-3-ol, (3 beta,
24R)-Stigmast-5-en-3-ol, Tetracontane, Squalene, Beta-stigmasterol.
Comprehensive Review of the Ethnomedicinal Uses, Pharmacological Effects and Flavonoids of Tephrosia species.
Authors: Kemboi Douglas , Ngyema Veronica , Tembu Jacqueline Vuyelwa 
Published: February 2024

Abstract:
Tephrosia is one of the largest genera in the Leguminosae (Fabaceae) family, with a
wide range of distribution in temperate and tropical climates. This review examines the literature
from 2000 to 2021 and focuses on medicinal uses, pharmacological research, and flavonoids extracted
from Tephrosia species. The review also highlights existing knowledge gaps in Tephrosia
species research, which could help speed up future studies aiming at discovering lead chemicals
from these species. Tephrosia species are used as pesticides, animal feed additions, and to
improve soil fertility through nitrogen fixation. Furthermore, Tephrosia species are frequently
used in traditional medicine to treat ailments such as gastro-duodenal disorders, chest pains,
chronic diarrhoea, inflammatory disorders, skin disorders, wounds, dysmenorrhea, asthma, elephantiasis,
haemorrhoids, and bronchitis. Several recent pharmacological studies have established
their efficacy as anti-plasmodium, anti-cancer, anti-protozoal, antibacterial, antifungal,
and anti-insecticidal drugs. Furthermore, flavonoids isolated from these species have been proven
to exhibit anti-plasmodia, anticancer, and anti-insecticidal properties, supporting the majority
of Tephrosia species' traditional applications. Over 140 flavonoids have been identified and isolated
from approximately 25 Tephrosia species to date. The majority of the isolated flavonoids
have O-substituted, C-methylated, or prenylated patterns and are flavonol, chalcone, flavone, or
flavanone. Notably, some of the flavonoids with unique skeletal structures were discovered for
the first time in the species. Most of the reported biological activity, however, requires further
testing against a wide range of diseases, though they can be recommended as possible promising
compounds.
Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review
Authors: Li Ruixuan , Tao Feng 
Published: February 2024

Abstract:
Adolescence is an immature but adventurous time period of exploration. Due to rapid
developments of the brain with unbalanced release of neurotransmitters, adolescents are prone
to impulsivity that may carry out potentially dangerous behaviors. According to the Centers for
Disease Control and Prevention, more than one-third of high school students have reported the
use of cannabis or marijuana in 2019, and the trend has not declined since. Previous studies
have shown that cannabis not only affects cognitive and social behaviors, but also produces
psychological responses to stress. In this review, we have summarized recent studies on cannabis-
produced effects during the unique period of adolescent development, and we have also
briefly discussed the legalization of cannabis. Though there are slight differences between cannabis
and marijuana, the major active component of them is tetrahydrocannabinol. We have
used the term “cannabis” in this review. Cannabis use in adolescents causes structural and functional
changes in the brain, increasing the probability of depression, which is also associated
with other illicit substance use, and impairs education achievement. Given that cannabis use can
cause detrimental harm to adolescents, it is suggested that adolescents should generally avoid
using cannabis in a recreational manner. More preclinical and clinical studies are needed to
provide detailed information for evidence-based decisions.
Machining Performance of Ti6Al4V Nano Composites Processed at Al2O3 Nano Particles Mixed Minimum Quantity Lubrication Condition
Authors: Anushkannan N.K , Sahu Santosh Kumar , Anil Kumar T. Ch. , Verma Ashish , Pragadish N. , Karthi V. , Kannan M. , Nayak Bijaya Bijeta 
Published: February 2024

Introduction:
In this research work, an attempt was made to machine
Ti6Al4V nano composites utilizing Al2O3 mixed nano fluid at minimum quantity lubrication
condition, in which experiments were designed using the L16 orthogonal
array, whereas Material Removal Rate, Surface Roughness, machining force and power
were recorded as responses.

Methods:
The nano composites were fabricated using the stir casting technique and the
nano particles were synthesized using the sol-gel technique. the microstructure revealed
that the homogeneous dispersion of particles with dendric arms. Increased cutting speed
and feed lead to more tool wear, which in turn causes a decrease in surface quality and an
increase in surface roughness.

Results:
Larger areas of cut are often the consequence of higher feed rates, which increases
the amount of friction between the work piece and the cutting edge. The machining
force increases when the feed rate is increased. A higher feed rate produces a
large volume of the cut material in a given length of time in addition to having a dynamic
impact on the cutting forces.

Conclusion:
It also results in a corresponding increase in the typical contact stress at
the tool chip interface and in the tool chip contact zone.
Research on Stiffness Analysis and Technology of the Heavy Spidle Top
Authors: Wang Yongkang , Gao Bingwei , Han Wenlong , Xue Shilong 
Published: February 2024

Background:
The spindle top is an important component used to withstand
the shaft workpiece on machine tools so that the spindle can meet high efficiency and
high precision requirements. However, the selection principles under various load
conditions are not stipulated in use. In addition, material selection, manufacturing,
heat treatment technology, etc., are of practical significance for the production of high
hardness, high wear resistance, and high precision spindle tops.

Objectives:
The spindle top type, material selection principles, heat treatment, cold
working, and other manufacturing processes are given. Provide a reference for highperformance
and top-notch design and manufacturing.

Methods:
The model of the spindle top will be created in UG software, then using
ANSYS finite element analysis software to analyze stiffness of spindle top whose
height-to-diameter ratios are 1:4 and 1:7 types in a variety of different load cases. The
design and manufacturing process of the spindle top is analyzed and expounded from
the selection and performance comparison of metal materials, heat treatment of different
materials, cold manufacturing technology, and other aspects.

Results:
The deformation laws of different types of spindle tops are obtained. According
to the deformation regular, find the selection principle of height to diameter
ratio of spindle top. The defects that are easy to occur in the technology are obtained
and the preventive and solution measures are put forward.

Conclusion:
According to the deformation regular, find the selection principle of
height to diameter ratio of spindle top. The material selection, heat treatment technology,
and other technical research on the spindle top provide the necessary basis for
the production of the spindle top.
Impact of a Nationwide Medication History Sharing Program on the Care Process and End-User Experience in a Tertiary Teaching Hospital: Cohort Study and Cross-Sectional Study
Authors: Cho Jungwon , Yoo Sooyoung , Lee Eunkyung Euni , Lee Ho-Young 
Published: February 2024

Abstract

Background
Timely and comprehensive collection of a patient’s medication history in the emergency department (ED) is crucial for optimizing health care delivery. The implementation of a medication history sharing program, titled “Patient’s In-home Medications at a Glance,” in a tertiary teaching hospital aimed to efficiently collect and display nationwide medication histories for patients’ initial hospital visits.

Objective
As an evaluation was necessary to provide a balanced picture of the program, we aimed to evaluate both care process outcomes and humanistic outcomes encompassing end-user experience of physicians and pharmacists.

Methods
We conducted a cohort study and a cross-sectional study to evaluate both outcomes. To evaluate the care process, we measured the time from the first ED assessment to urgent percutaneous coronary intervention (PCI) initiation from electronic health records. To assess end-user experience, we developed a 22-item questionnaire using a 5-point Likert scale, including 5 domains: information quality, system quality, service quality, user satisfaction, and intention to reuse. This questionnaire was validated and distributed to physicians and pharmacists. The Mann-Whiteny U test was used to analyze the PCI initiation time, and structural equation modeling was used to assess factors affecting end-user experience.

Results
The time from the first ED assessment to urgent PCI initiation at the ED was significantly decreased using the patient medication history program (mean rank 42.14 min vs 28.72 min; Mann-Whitney U=346; P=.03). A total of 112 physicians and pharmacists participated in the survey. Among the 5 domains, “intention to reuse” received the highest score (mean 4.77, SD 0.37), followed by “user satisfaction” (mean 4.56, SD 0.49), while “service quality” received the lowest score (mean 3.87, SD 0.79). “User satisfaction” was significantly associated with “information quality” and “intention to reuse.”

Conclusions
Timely and complete retrieval using a medication history-sharing program led to an improved care process by expediting critical decision-making in the ED, thereby contributing to value-based health care delivery in a real-world setting. The experiences of end users, including physicians and pharmacists, indicated satisfaction with the program regarding information quality and their intention to reuse.
Kekerabatan Genetik 50 Klon Kina (Cinchona ledgeriana) Berdasarkan Karakter Morfologi pada Fase Tanaman Belum Menghasilkan (TBM)
Authors: Vina Dwiayu Wardhani  , Vitria Puspitasari Rahadi , Heri Syahrian , M. Khais Prayoga 
Published: February 2024

Kina (Cinchona) merupakan tanaman yang banyak dibudidayakan di Indonesia karena memiliki kandungan alkaloid, kinin sulfat, dan saponin yang baik untuk kesehatan manusia. Untuk merakit varietas unggul baru melalui persilangan buatan perlu diketahui data tingkat kekerabatan antar klon terlebih dahulu dalam memilih tetua. Tujuan penelitian ini yaitu mengetahui tingkat kekerabatan 50 klon koleksi plasma nutfah kina berdasarkan karakter morfologi. Penelitian dilaksanakan di kebun kina Pusat Penelitian Teh dan Kina Gambung, Kabupaten Bandung, Jawa Barat, mulai bulan Juli sampai Agustus 2022. Karakter morfologi tanaman kina yang diamati yaitu tinggi tanaman, jumlah daun, diameter batang, panjang daun, lebar daun, bentuk daun, bentuk pangkal daun, dan jumlah tulang daun. Tingkat kekerabatan 50 klon kina ditentukan dengan metode analisis komponen utama (Principal Component Analysis/PCA) dan analisis klaster (Cluster Analysis) dengan menggunakan aplikasi PAST3 sehingga menghasilkan dendrogram antar klon kina. Hasil penelitian menunjukkan bahwa 50 klon plasma nutfah kina yang diteliti memiliki keragaman pada karakter morfologi tinggi tanaman, jumlah daun, dan bentuk daun dengan nilai koefisien keragaman masing-masing 32,09%, 36,36%, dan 48,85%. Hasil dendrogram 50 klon tersebut terbagi menjadi 4 kelompok pada titik potong jarak di atas skala 25, sedangkan jarak ketidakmiripan mencapai skala 40. Kelompok I terdiri dari 14 klon dengan karakteristik morfologi bentuk daun tipe 2. Kelompok II terdiri dari 2 klon dengan karakteristik morfologi bentuk daun tipe 1. Kelompok III terdiri dari 26 klon dengan karakteristik morfologi bentuk daun tipe 3. Sedangkan kelompok IV terdiri dari 6 klon dengan morfologi bentuk daun tipe 4.
Mediating Role of Socio-Religious Behavior to Changes in Selection of Imported Food Among Millennial Muslims
Authors: Andi Wahda  , Marzuki Sitti Nikmah , Jumarni  
Published: February 2024

The aim of this research is to reveal the influence of attitudes, subjective norms and perceived behavioral control on interest in purchasing imported food and beverage products labeled halal through religiosity as a moderating variable (Study of Generation Z, Bone Regency). The type of research used is explanatory research or explanatory research. The analysis technique used in this research is Partial Least Square (PLS) and the data is processed using SmartPLS software. This method is used as an alternative to variance-based SEM and has the advantage that this method can be estimated with a small number of samples. This research uses the help of SmartPLS software which was built with the aim of measuring variant-based structural equations. There are several steps that must be carried out in this method with the help of SmartPLS software. There are analysis stages using the Partial Least Square (PLS) method, namely: 1) Creating a model concept, 2) The specified algorithm analysis method, 3) The specified resampling method, 4) Drawing a path diagram, 5) Evaluating the model. The conclusions of this research: 1) Attitude has a positive and significant influence on interest in purchasing imported food and beverage products labeled halal; 2) Subjective norms have no effect on interest in purchasing imported food and beverage products labeled halal; 3) Perceived behavioral control has a positive and significant influence on interest in purchasing imported food and beverage products labeled halal; 4) Religiosity has a positive and significant influence on interest in purchasing imported food and beverage products labeled halal; 5) Religiosity does not moderate the influence of attitudes on intention to buy imported food and drinks labeled halal; 6) Religiosity does not moderate the influence of attitudes on intention to buy imported food and drinks labeled halal; 7) Religiosity does not moderate the influence of perceived behavioral control on interest in buying imported food and drinks labeled halal.

Keywords: Religious; Millennial Muslims; Socio-religious behavior; Imported food; Indonesia
The Implementation of EU Legislation on Energy Communities into Polish Law
Authors: Lissoń Piotr 
Published: February 2024

Abstract
The subject of this article is the issues related to the obligation to implement into Polish law the provisions of the European Union (EU) law concerning citizen energy communities (CECs) and renewable energy communities (RECs), contained in Directives 2019/944 and 2018/2001. The method of implementing the provisions of EU law into Polish law is to be based on the establishment of a single set of regulations, as provided for in the draft Act amending the Energy Law and certain other Acts of 26 January 2023 (draft No. UC74 developed by the Ministry of Climate and Environment). It is to include regulations relating to both types of communities (CECs and RECs), but to use only one name – CECs. The article presents and critically analyses the proposed regulations and the adopted method of their allocation in the acts of Polish law.