bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organ sparing to cure stage IV rectal cancer: A case report and review of literature
Authors: Meillat Hélène , Garnier Jonathan , Palen Anais , Ewald Jacques , de Chaisemartin Cécile , Tyran Marguerite , Mitry Emmanuel , Lelong Bernard 
Published: November 2023

BACKGROUND
Rectal sparing is an option for some rectal cancers with complete or good response after chemoradiotherapy (CRT); however, it has never been evaluated in patients with metastases. We assessed long-term outcomes of a rectal-sparing approach in a liver-first strategy for patients with rectal cancer with resectable liver metastases.
CASE SUMMARY
We examined patients who underwent an organ-sparing approach for rectal cancer with synchronous liver metastases using a liver-first strategy during 2010-2015 (n = 8). Patients received primary chemotherapy and pelvic CRT. Liver surgery was performed during the interval between CRT completion and rectal tumor re-evaluation. Clinical and oncological characteristics and long-term outcomes were assessed.
All patients underwent liver metastatic resection with curative intent. The R0 rate was 100%. Six and two patients underwent local excision and a watch-and-wait (WW) approach, respectively. All patients had T3N1 tumors at diagnosis and had good clinical response after CRT. The median survival time was 60 (range, 14-127) mo. Three patients were disease free for 5, 8, and 10 years after the procedure. Five patients developed metastatic recurrence in the liver (n = 5) and/or lungs (n = 2). Only one patient developed local recurrence concurrent with metastatic recurrence 24 mo after the WW approach. Two patients died during follow-up.
CONCLUSION
The results suggest good local control in patients undergoing organ-sparing strategies for rectal cancer with synchronous liver metastasis. Prospective trials are required to validate these data and identify good candidates for these strategies.
Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature
Authors: Huang Chun-Chun , Ying Le-Qian , Chen Yan-Ping , Ji Min , Zhang Lu , Liu Lin 
Published: November 2023

BACKGROUND
The prevalence of multiple primary malignant neoplasms (MPMNs) is increasing in parallel with the incidence of malignancies, the continual improvement of diagnostic models, and the extended life of patients with tumors, especially those of the digestive system. However, the co-existence of MPMNs and duodenal adenocarcinoma (DA) is rarely reported. In addition, there is a lack of comprehensive analysis of MPMNs regarding multi-omics and the tumor microenvironment (TME).
CASE SUMMARY
In this article, we report the case of a 56-year-old man who presented with a complaint of chest discomfort and abdominal distension. The patient was diagnosed with metachronous esophageal squamous cell carcinoma and DA in the Department of Oncology. He underwent radical resection and chemotherapy for the esophageal tumor, as well as chemotherapy combined with a programmed death-1 inhibitor for the duodenal tumor. The overall survival was 16.6 mo. Extensive evaluation of the multi-omics and microenvironment features of primary and metastatic tumors was conducted to: (1) Identify the reasons responsible for the poor prognosis and treatment resistance in this case; and (2) Offer novel diagnostic and therapeutic approaches for MPMNs. This case demonstrated that the development of a second malignancy may be independent of the location of the first tumor. Thus, tumor recurrence (including metastases) should be distinguished from the second primary for an accurate diagnosis of MPMNs.
CONCLUSION
Multi-omics characteristics and the TME may facilitate treatment selection, improve efficacy, and assist in the prediction of prognosis.
Calibração de um modelo computacional de uma habitação multifamiliar localizada na cidade de João Pessoa-PB
Authors: Dionísio Danielly Freires de Farias , Leder Solange Maria 
Published: November 2023

O objetivo deste artigo é apresentar a calibração de um modelo computacional de uma habitação de interesse social (HIS) multifamiliar localizado na cidade de João Pessoa, através da comparação entre as temperaturas do ar interno medidas in loco e de valores simulados no programa EnergyPlus. A metodologia utilizada para o desenvolvimento desta pesquisa consiste em três etapas: monitoramento de uma edificação residencial multifamiliar com a realização de medições de temperatura e umidade relativa do ar; modelagem computacional da edificação, e, por fim, calibração do modelo de simulação através de análise de sensibilidade utilizando como indicadores NMBE, CV(RMSE), o coeficiente de correlação (R) e o coeficiente de determinação (R²) da regressão linear entre os valores medidos e os valores simulados de temperatura do ar. Foram analisadas variações na resistência térmica dos materiais, absortância dos materiais, ganhos internos de calor por equipamentos, padrões de uso e ocupação e infiltração de ar. Os resultados demonstraram que o modelo inicial já apresentava bons resultados podendo ser considerado calibrado de acordo com os requisitos da ASHRAE Guidelines 14. Alguns fatores podem ter contribuído para um bom resultado da modelagem inicial como o fato de se considerar o entorno da edificação, além de simular a ventilação natural considerando os coeficientes de pressão calculados por uma ferramenta CFD. No procedimento de calibração por análise de sensibilidade observou-se um incremento mais considerável no R² para o ambiente quarto no inverno.
Espaços públicos e qualidade ambiental
Authors: Ramos Larissa Leticia Andara , Jesus Luciana Aparecida Netto de , Silva Eduardo Barroso Mozelli da 
Published: November 2023

Com o crescimento dos centros urbanos, os espaços livres públicos e as áreas verdes são frequentemente suprimidos, afetando não apenas a paisagem urbana, que se afasta cada vez mais da natureza, mas também as condições climáticas locais. Diante deste cenário, torna-se necessário uma melhor distribuição e adequação desses espaços de modo a garantir o equilíbrio do metabolismo urbano. Este artigo tem como objetivo analisar e comparar aspectos bioclimáticos e urbanos de duas praças, localizadas na Regional Centro do município de Vila Velha-ES, identificadas com base nos resultados da avaliação da qualidade ambiental, a partir da aplicação da ferramenta analítica-classificatória “QualificaURB”. A metodologia incluiu medições in loco da temperatura, velocidade e umidade do ar das praças analisadas, bem como levantamento de dados meteorológicos observados nas estações automáticas próximas ao contexto urbano estudado, buscando identificar aspectos ambientais e urbanos, associados às praças, que estariam influenciando nas variações climáticas. Como resultado, destaca-se a importância da relação praça e seu entorno construído, bem como a influência positiva das praças urbanas no microclima local, sendo aquela com maior densidade de vegetação, a que apresentou temperaturas mais amenas, confirmando, assim, que a presença de áreas verdes e permeáveis está associada ao conforto proporcionado por esses espaços.
Ventilação e percepção térmica de idosos
Authors: Silveira Julio Gonçalves da , Leder Solange Maria 
Published: November 2023

O envelhecimento da população brasileira suscita investigações que proporcionem caracterização da população idosa em relação ao ambiente térmico. O aumento das médias de temperatura do ar, influenciadas pelas mudanças climáticas, afetam diretamente o conforto térmico dos indivíduos. Sendo que, especialmente os idosos estão propensos a vulnerabilidade térmica tendo em vista as alterações fisiológicas acarretadas pelo avanço da idade. Investigar a interação entre variáveis de conforto e percepção térmica permite ampliar as decisões relativas ao bem-estar desta população. Assim, esse estudo, procurou caracterizar as inter-relações entre a ventilação externa, ventilação interna e a temperatura do ar interna e o impacto dessas variáveis ambientais na percepção de conforto térmico em idosos em climas tropicais distintos. A coleta de dados foi realizada em unidades habitacionais unifamiliares construídas especificamente para abrigar idosos. Elas estão localizadas nas cidades de João Pessoa, Campina Grande e Cajazeiras, estado da Paraíba, locais de clima quente-úmido e semiárido. A ventilação influenciou diretamente a temperatura do ar e a percepção de conforto térmico de idosos. Considerando a percepção de conforto térmico e a ventilação interna, quando registradas velocidades do ar acima de 0,9m/s a probabilidade de resposta favorável ao conforto é de 75,0%. Este estudo apresentou que os idosos possuem significativa sensibilidade à velocidade do vento, associando-a ao conforto térmico.
The Impact of Chemotherapy on Dietary Status as Well as Life Quality in Kids with Cancer in Belgium
Authors: Patrick Dr. Jean 
Published: November 2023

Purpose: The purpose of this study was to evaluate the impact of chemotherapy on dietary status as well as life quality in kids with cancer in Belgium.
Methodology: The study used a desktop literature review methodology (desk study). This required a thorough analysis of research on the impact of chemotherapy on dietary status as well as life quality in kids with cancer. The subject of the study underwent three phases of sorting in order to assess its suitability for further study.
Findings: This study concluded that chemotherapy was associated with poor dietary status and reduction in the life quality ratings. The use of the Nutrition Impact Symptom (NIS) checklist in the kid’s oncology clinic/ward triggers more therapeutic interventions. The awareness for NIS will likely evoke more research in assessment, impact, and treatment.
Unique Contribution to Theory, Practice and Policy: This study recommended that individual’s food preferences and aversions should be considered and combinations of oral, enteral and parenteral diet be provided. In view of the findings, the study recommends that dietetics should frequently carry out diet assessments in order to provide proper management to curb malnutrition.
Pregnant Adolescent Girls' Dietary Habits and Status in Mali
Authors: Tambadou Dr. Youssouf 
Published: November 2023

Purpose: The purpose of this study was to evaluate dietary habits and nutrition status of pregnant adolescents.
Methodology: The study used a desktop literature review methodology (desk study). This required a thorough analysis of research on the dietary habits and nutrition status of pregnant adolescents. The subject of the study underwent three phases of sorting in order to assess its suitability for further study.
Findings: This study concludes that the poor nutrition status was associated with inadequate dietary intake and frequent illness. The low knowledge was attributed to low education level and poor health seeking behavior. The low knowledge translated to poor decision making in dietary practices.
Unique Contribution to Theory, Practice and Policy: This study recommends ministry of Health at National level to enhance the use of the existing training package and policy in counselling pregnant adolescents. It should also come up with a counselling package and policy for use in counselling these mothers.
The Current State of Consumers' Use of Nutritional Knowledge on Processed Meat Products in Brazil
Authors: Furtado Prof. Fernando 
Published: November 2023

Purpose: The purpose of this study was to determine the status of utilization of nutrition information in purchasing decisions of processed meat products in Brazil.
Methodology: The study used a desktop literature review methodology (desk study). This required a thorough analysis of research on the status of utilization of nutrition information in purchasing decisions of processed meat products. The subject of the study underwent three phases of sorting in order to assess its suitability for further study.
Findings: The study concluded that there is no significant relationship between utilization of nutrition information on processed meat products and the purchasing patterns of processed meat products among consumers in supermarkets in Brazil.
Unique Contribution to Theory, Practice and Policy: According to the report, Manufacturers should educate consumers on the importance of reading nutrition information on the labels and using the information to make healthful purchasing decisions.
Anthropometric and Biochemical Indices of Infants fed Complementary Foods developed from Millets, Orange-Fleshed Sweet Potatoes, Carrot, Periwinkle and Oyster Meat Flour Blends
Authors: Orisa Catherine.A. , Nnam N.N. , Mbah B.O. 
Published: November 2023

Purpose: This study examined the anthropometric and biochemical indices of infants fed complementary foods developed from millets (M), orange-fleshed sweet potatoes (OFSP), carrot (CF), periwinkle meat (PMF) and oyster meat flour (OMF) blends.
Materials and Methods: Six different blends of flour were formulated using the recommended guideline for the formulation of complementary food for infants 6 – 12 months. The blends were as follows 89: 11 M/C; 70:30 M/OFSP; 57:32:11 M/OFSP/C; 65:20:5:10 M/OFSP/C/OMF; 49:29:7:15 M/OFSP/C/PMF and 70:13:3: 7:7 M/OFSP/C/PMF/OMF while Cerelac was used as the control diet. Thirty-five children aged 6-12 months enrolled in this study. Seven groups comprising of 5 children each consumed cerelac (control diet), millet/carrot (Test diet I) millet/OFSP (test diet II), millet/OFSP/carrot (test diet III), millet/OFSP/carrot/oyster (test diet IV), millet/OFSP/carrot/periwinkle (test diet V), and millet/OFSP/carrot/periwinkle/oyster (test diet VI), respectively.
Findings: The children were fed with 50 g/day of the diets over a 6 months period during which anthropometric (weight, length, mid-upper arm circumference, head circumference, and chest circumference) and biochemical assessments (iodine level, hemoglobin level, calcium level, and vitamin A level) were carried out before and after test product ingestion. All children fed on the test diets had an increase in anthropometric parameters. Test diet VI had the highest percentage effect on biochemical and anthropometric parameters at the end of the study. The effect of test diet VI on the hemoglobin levels of the infants was significantly (p<0.01) higher than other test diets.
Implication to Theory, Practice and Policy: Dietary interventions incorporating carrots, OFSP, periwinkle, and oyster exhibited favorable impacts on the nutritional well-being of infants. Consequently, it ought to be regarded as a superior choice when devising nutrition initiatives aimed at enhancing the nutritional condition of children residing in regions where millet-based porridge prevails as the primary complementary food.
Pengaruh Penambahan Rumput Laut (Eucheuma cottonii) Pada Pembuatan Sampo Ditinjau Dari Nilai Ph Dan Uji Tinggi Busa
Authors: Edi Safriyanto 
Published: November 2023

ABSTRAK
Rumput laut jenis ini merupakan salah satu carragenophytes yaitu rumput laut penghasil karaginan. Hasil olahan dari rumput laut Eucheuma cottonii banyak digunakan sebagai pengemulsi, pembentuk gel, penstabil, dan pengental. Penelitian ini bertujuan untuk menentukan formulasi rumput laut Eucheuma cottonii yang menghasilkan sampo yang baik ditinjau dari nilai pH dan tinggi busa sedangkan manfaat yang diharapkan dari penelitian ini ialah dapat meningkatkan pengetahuan dan keterampilan mengolah rumput laut Eucheuma cottonii sehingga mampu mengembangkan IPTEK pengolahan rumput laut Eucheuma cottonii di Sulawesi Tengah. Adapun metode rancangan yang digunakan ialah metode analisis secara RAL (Rancangan Acak Lengkap) kombinasi, perlakuan yang diterapkan adalah pengaruh konsentrasi rumput laut Eucheuma cottonidan santan kelapa. Konsentrasi rumput laut Eucheuma cottoniterdiri atas 7 tingkatan, masing-masing 1%, 1,5%, 2%, 2.5%, 3%, 3,5 %,dan 4%. Konsentrasi santan kelapa yang digunakan terdiri atas 4 taraf masing-masing 5%, 10%, 15% dan 20 %. Perlakuan diulangi 2 kali dan parameter yang diamati adalah pH dan uji tinggi busa. Hasil penelitian menunjukkan bahwa nilai pH sampo berbasis rumput laut Eucheuma cottonii pada setiap perlakuan menunjukkan bahwa tidak berbeda nyata nilai pH setiap perlakuan, sementara untuk perlakuan tinggi busa perlakuan yang terbaik yaitu perlakuan A5 dengan rata-rata tinggi busa 13,25 cm dengan penurunan busa sekitar 84%. Untuk mendapatkan kualitas dan kuantitas sampo berbasis rumput laut Eucheuma cottonii berdasarkan setiap perlakuan yang sesuai dengan standar yang diterapkan, maka konsentrasi yang baik ada pada perlakuan A5. Nilai pH dan tinggi busa atau buih pada penelitian ini secara umum memenuhi standar mutu sampo yang ditetapkan SNI.

Kata kunci: Rumput laut, Sampo, Nilai Ph Dan Uji Tinggi Busa
Model of the system of goals of punishment: from presuming to rational construction
Authors: Дворянсков И.В. 
Published: November 2023

В статье рассматриваются доктринальные (научные) и правовые основы концептуальной модели целей наказания, отражающей его сущность и функции как социального и правового феномена. Приводится критика существующих целей наказания, формулируется вывод о необхо- димости перехода при их моделировании от презюмирования к рациональному конструированию. Исходя из сущностного подхода к наказанию, следует выделять следующие его онтологические аспекты: принуждение, кара, обезличивание (в правовом и психологическом смысле), возмездный характер. В целом же сказанное обусловливает два вывода: 1) наказание в силу своего механизма воздействия на реальность не может иметь целей, связанных с конструкцией будущего, но должно быть направлено на оценку и пресечение преступления как явления, которое произошло в прошлом; 2) конструктивные цели должны создавать основу для следующих за наказанием (постпенальных) мер (профилактики, ресоциализации, социальной адаптации и прочего). На основании полученных данных делается обоснование авторской телеологической модели наказания, формулируются его основные цели.
The article deals with the doctrinal (scientific) and legal foundations of the conceptual model of the goals of punishment, reflecting its essence and functions as a social and legal phenomenon. Criticism of the existing goals of punishment is given, a conclusion is formulated about the need to move from presuming to rational construction in their modeling. Based on the essential approach to punishment, the following ontological aspects should be singled out: coercion, punishment, depersonalization (in the legal and psychological sense), retributive character. In general, the above leads to two conclusions: 1) punishment, due to its mechanism of influence on reality, cannot have goals related to the construction of the future, but should be aimed at assessing and suppressing a crime as a phenomenon that occurred in the past; 2) constructive goals should form the basis for the following punishment (post-penal) measures (prevention, resocialization, social adaptation, etc.). Based on the data obtained, the author's teleological model of punishment is substantiated, and its main goals are formulated.
PENERAPAN MODEL PROBLEM BASED LEARNING DALAM PEMBELAJARAN TEKS DISKUSI PADA PESERTA DIDIK KELAS 9 SMP N 3 KENDAL TAHUN PELAJARAN 2022/2023
Authors: Damayanti Fita Dwi , Budiawan Raden Yusuf Sidiq , - Mukhlis 
Published: November 2023

Penelitian ini bertujuan untuk mendeskripsikan penerapan model Problem Based Learning dalam pembelajaran Teks Diskusi pada peserta didik kelas 9 SMP N 3 Kendal tahun pelajaran 2022/2023. Jenis penelitian ini adalah kualitatif deksriptif yang didukung dengan data kuantitatif (campuran). Pengumpulan data dalam penelitian ini dilakukan dengan teknik tes dan nontes yang berupa angket, observasi, wawancara, dan dokumentasi. Analisis data dalam penelitian ini dilakukan dengan teknik triangulasi. Penyajian data dalam penelitian ini dilakukan dengan metode formal dan informal. Hasil dalam penelitian ini menunjukkan bahwa model Problem Based Learning dapat diterapkan dalam pembelajaran Teks Diskusi pada peserta didik kelas 9 SMP N 3 Kendal. Berdasarkan hasil tes, wawancara, observasi, dan angket, model Problem Based Learning mampu meningkatkan pemahaman peserta didik tentang materi pembelajaran Teks Diskusi, mampu meningkatkan keterampilan berpikir kritis peserta didik, mampu menjadikan peserta didik semakin aktif dalam proses pembelajaran, serta dapat menjadikan suasana kelas menjadi lebih kondusif.
PENERAPAN MODEL PEMBELAJARAN THE POWER OF TWO DALAM MENINGKATKAN HASIL BELAJAR SISWA DI SMP NEGERI 4 ALASA
Authors: Jaya Zalukhu Tober Putra , Harefa Yearning , Zebua Serniati , Lase Asali 
Published: November 2023

Penerapan Model PembelajaranThe Power Of Two adalah salah satu model pembelajaran yang menggunakan adanya kerjasama antara siswa dalam kelompok untuk mencapai tujuan pembelajaran dan siswa dibagi menjadi kelompok-kelompok kecil serta diarahkan untuk mempelajari materi pelajaran yang telah ditentukan. Berdasarkan hasil observasi guru pada siklus I persentase pengamatan adalah 65,8 dan pada siklus II meningkat menjadi 85,83% Hasil observasi aktifitas siswa pada siklus I dengan persentase pengamatan aktivitas siswa adalah 48,87% dan pada siklus II meningkat menjadi 88,82%, Prestasi belajar siswa pada siklus I nilai rata-rata mencapai 64,9,dan persentase ketuntasan belajar = 22,72%,dan pada siklus II nilai rata-rata meningkat menjadi 78,80 dengan ketuntasan belajar = 81,81%.Dengan demikian disimpulkan bahwa meningkat aktivitas siswa dan hasil belajar pada proses pembelajaran IPS Terpadu, dan penerapan model pembelajaranthe power of twodapat diterapkan pada mata pelajaran IPS Terpadu.
The Influence of Online Customer Review, Customer Rating, and Viral Marketing on Purchase Decisions in Generation Z at Tokopedia
Authors: Kamal Aida Faradilla , Nobelson Nobelson , Supriadi Yudi Nur 
Published: November 2023

Tokopedia is the most visited e-commerce platform in Indonesia. But now there is a problem because Tokopedia is still below its competitors in purchasing decisions for generation Z. So the problem formulation in this study is whether customer reviews, customer ratings, and viral marketing influence purchasing decisions. This study has the objective of knowing, proving, and analyzing the influence of customer reviews, customer ratings, and viral marketing on purchasing decisions. The population in this study is generation Z consumers who have made purchases at Tokopedia in Jakarta. The sample used was 100 respondents, with quantitative data types and non-probability sampling methods (purposive sampling). The analysis technique uses Partial Least Square (PLS) with SmartPLS 3.0 software. The results of this study indicate that the variables customer review, customer rating, and viral marketing have a positive and significant impact on purchasing decisions. This study obtained the result that the customer review variable had the highest influence on the t-statistic test, which was 49.2%.

Keywords:customer reviews, customer ratings, viral marketing,purchase decision, e-commerce