bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of medically supervised fasting on the vitamin D, glycemic control, quality of life and need for medication among type 2 diabetes mellitus: Protocol for a randomized control trial (FAVIT Trial)
Authors: Nair Pradeep M. K. , Silwal Karishma , Kodali Prakash Babu , Sharma Hemanshu , Tewani Gulab Rai 
Published: November 2023

Abstract

Objective
The objective of this study is to investigate the effect of prolonged medically supervised fasting (PMSF) for 6 months on vitamin D levels and diabetes-related clinical outcomes in type 2 diabetes mellitus (T2DM) patients.

Methods
This is an open-label, parallel arm, randomized control trial; 170 T2DM patients from a complementary medicine setting, aged between 20 and 70 years, with a body mass index >25 kg/m2 and glycated hemoglobin (HbA1C) levels >6% and <12%, treated with lifestyle advice and/or oral hypoglycemic drugs, will be randomized to receive PMSF or a diabetic diet (DD), along with their usual care. The patients will be initially trained in PMSF and DD for a duration of 10 days in the study setting, followed by 5 months of practice at their respective residences. The PMSF will fast for five days a month for three consecutive months after the initial exposure, whereas the DD group will follow the same diet for 6 months. Other than fasting days, the PMSF group will follow the same DD as the control group. The primary outcome is an improvement in vitamin D levels, and the secondary outcomes include serum calcium, insulin levels, insulin resistance, blood cell counts, anthropometrics, quality of life, medication score, compliance rate, and disease perception.

Discussion
In this study, we hypothesize that PMSF would gradually increase vitamin D levels, which would increase calcium levels, which would promote insulin secretion and upregulate its function. This may help reduce the need for diabetic medication and result in diabetic remission.
The city as memory in contemporary Polish women's literature
Authors: Gaál Gabriella 
Published: November 2023

The research is based on the hypothesis that geographical spaces reflect the imprint of social, political, historical and cultural life. Spatial representations of settlements are the projections of social crisis and historical periods. The city has its own vocabulary and language, reflected in its buildings and spaces. These 'speaking' cities are open in space and time, and become theatres of self-writing, as the spaces of the city try to find forms of expression to see unspoken traumas, that is, theories of the city are also theories of the subject.
The main question of the investigation is: what are the specific possibilities and challenges for Polish contemporary women's literature to mobilise social memory and to create possibilities for confronting the traumatic past? Using examples from Olga Tokarczuk's novels Dom dzienny, dom nocny (Day House, Night House) and Joanna Bator's Piaskowa Góra (Sand Hill), I will present the relationship between memory and coming to terms with the past in the historical context of East-Central Europe in Poland. In particular, I will focus on the ways of reflecting on historical events of the Second World War and the regime change of 1989.
A further aim of the research is to explore how Polish women's literature after 1989 attempts to come to terms with the great social traumas of the twentieth century. In the following, I intend to examine the fictional representation of the culture of memory of the 1989/90 regime change in the body of contemporary Hungarian and Polish women's literature in order to find a common intersection of Central and Eastern European literatures.
Individual vs community resilience: Case of Georgia
Authors: Tavberidze Zakaria , Margvelashvili Anna , Zurabishvili Tamar 
Published: November 2023

Present Paper examines the concepts of individual and community resilience in Georgia. The goal of the present paper is to investigate the interplay between individual and community resilience in the context of donor-funded initiatives at the local rural level through the creation and strengthening of Community-Based Organizations (CBO).
Present findings are based on ample fieldwork conducted in Georgia in 2022 among the active rural CBOs, using a mixed-method approach: 1) a quantitative phone survey of CBOs; 2) Focus group discussions with beneficiaries of the CBOs’ activities (both online and face-to-face); 3) in-depth interviews with the leaders of the CBOs; 4) in-depth interviews with the representatives of the local self-government, and 5) expert interviews with representatives of donor organizations working to increase the resilience of local communities.
Based on the data analysis and triangulation, the paper argues that resilience building in Georgian communities is mainly undertaken by the development partners using the top-down approach, and while on an individual level, these interventions do increase resilience, on a community level the impact is much less evident, and in some cases, non-existent. The theoretical and practical implications of our findings are extremely relevant since this is the first attempt to analyze the concept of resilience in the Georgian context and the findings contribute to further future analysis in this regard. On a practical level, our findings could be instrumental for the developmental partners, working in this area in Georgia, to adjust their programming to achieve more sustainable results not only on the individual but community levels.
Social representations attributed to prostate cancer by men undergoing follow-up at an in-hospital Oncology service
Authors: Peloso-Carvalho Bianca de Moura , Lima Rogério Silva , Silva José Vitor da , Sawada Namie Okino , Dázio Eliza Maria Rezende , Nascimento Murilo César do , Fava Silvana Maria Coelho Leite 
Published: November 2023

Objective: to understand the social representations of prostate cancer by men undergoing follow-up at an in-hospital oncology service. Methods: a qualitative study, developed using the Collective Subject Discourse method, with 30 men over the age of 18 undergoing treatment for prostate cancer. The data were collected through semi-structured interviews and analyzed using the Theory of Social Representations. Results: the most shared central ideas in the studied community were as follows: A curable disease; Worry, fear, annoyance and sadness; Loss/Impairment of sex; Nothing, something normal/common; A minor ailment that doesn't shake/shook me, it was faced head on, without fear; Something/Disease that is bad, difficult, serious, intense, dangerous, that ends life and kills. Conclusion: the social representations found in this study denoted intense and difficult experiences in dealing with the disease and treatment, but also showed coping, with potential for overcoming/resilience. Contributions to practice: understanding these representations enables the implementation of integrated and interprofessional education, assistance and management actions.
EDUCAÇÃO “À LA RUSSE”:
Authors: Cubas Caroline Jaques 
Published: November 2023

Este artigo apresenta e analisa um conjunto de artigos de opinião, publicados em periódicos impressos de grande circulação entre 1964 e 1969, acerca de eventos considerados subversivos em colégios católicos dirigidos por freiras. Os eventos denunciados iam do desencorajamento à participação na Marcha da Família com Deus pela Liberdade até a indicação de leituras consideradas inadequadas, pelo manifesto conteúdo sexual. Através deles, os articulistas aproximavam de forma bastante imediata a política à moral, a educação progressista à subversão. Dessa forma, contribuíam, com maior ou menor intensidade, para justificar a instauração e, em alguns casos, o recrudescimento do regime militar, via argumentos morais. O foco da análise assenta-se em textos assinados por Assis Chateaubriand, Mario Masagão, Salomão Jorge e Gustavo Corção, publicados majoritariamente em O Estado de São Paulo e na Folha de São Paulo. A análise destes artigos, entendidos como elementos constitutivos de um presente passado (KOSELLECK, 2014), intenta contribuir com o debate sobre as relações entre a imprensa e o regime autoritário brasileiro no que diz respeito a questões concernentes à educação (progressista) em colégios católicos femininos.
Optimization of the operation of existing district heating systems
Authors: Garbai László , Jasper Andor , Sánta Róbert 
Published: November 2023

AbstractThis study examines the economic optimisation of existing district heating systems. A new approach has been taken to solving a long-standing problem. The authors describe the input-output model of the system, the balance equations for the thermal equilibrium of the system, and the heat transfer system. From the balance equations of the series-connected system elements, the resultant heat transfer balance equation and the resultant power transmission equation are derived. In an example, the authors detailed how perturbations in some input variables can be corrected with other variables. The equations presented and the concepts introduced form absolutely new scientific results.
Kierunki rozwoju badań myśli politycznej – wprowadzenie do dyskusji nad problematyką
Authors: Radomski Grzegorz , Tomaszewski Patryk 
Published: November 2023

Autorzy ukazują obszary badań z zakresu myśli politycznej analizowane przede wszystkim przez polskich naukowców, ale uwzględniają badania prowadzone w innych państwach. Szukają przy tym odpowiedzi na pytanie, czy polskie badania nad myślą polityczną odbiegają od trendów prezentowanych w innych państwach. Artykuł ukazuje różnorakie spojrzenia na samą definicję myśli politycznej i kategorii pokrewnych, jak doktryna czy też ideologia. Analizując różne ujęcia teoretyczne badań nad myślą polityczną w Polsce, autorzy starają się odpowiedzieć na pytanie, czy możliwe jest uporządkowanie metod i technik badawczych na tyle, aby stanowiły uniwersalny model, którym mogą się posługiwać badacze. Zdaniem autorów w Polsce nadal będzie się toczyła dyskusja na temat przedmiotu zainteresowania myśli politycznej, a także będą trwały poszukiwania definicji odróżniającej myśl polityczną od ideologii i doktryny politycznej. Poza tym mimo rozwoju różnego typu technik badawczych, np. analizy danych (Big data), nadal będą podejmowane badania wyjaśniające i porządkujące świat myślenia politycznego, wpisując go w różne nurty myśli politycznej.
Paradoxical Hemiparesis from Cerebellopontine Angle Tumor: A Case Report
Authors: Gaharu Maula Nuruddin , Gunawan James 
Published: November 2023

Objective: To report a vestibular schwannoma in the cerebellopontine angle presenting with paradoxical hemiparesis with the Kernohan-Woltman Notch Phenomenon (KWNP).Methods: A 31-year-old female presented to the neurology clinic at Bhayangkara Hospital TK. I R. Said Sukanto, Indonesia, on 29 November 2021 with loss of balance, hearing, vision, and weakness in her left arm and leg. On physical examination, the patient had reduced left arm and leg muscle strengths against resistance (MRC grade 4), face deviation to the left, abnormal finger-to-nose test, dysdiadochokinesia, and inability to perform tandem gait. She was admitted for a brain MRI but did not return to the hospital for re-evaluation and surgery. Results: The brain MRI showed a mass on the left side of the cerebellum with a size of 4.44x3.93x4.93 cm, suggesting vestibular schwannoma. The mass also caused the obliteration of the ventricle, causing hydrocephalus.Conclusion:KWNP is an unusual finding resulting in a paradoxical hemiparesis, a false-localizing neurologic sign. Physicians should recognize KWNP in patients with hemiparesis, especially in space-occupying lesions. Imaging studies can help localize the lesion to minimize misdiagnosis and optimize patient treatment.
VALUE ADDITION OF ERI SILK YARNS WITH ALLAMANDA GRANDIFLORA - A NATURAL COLOURANT
Authors: Rajulagari. Sujatha,  A. Poornima  
Published: November 2023

Eri silk is one of the four varieties of silk mostly available in northeastern region of India. Recent trends in the world market of silk revealed that eri silk had tremendous potential as it was gifted with unique properties of protecting human body from some aliments as well as its use as fashionable dress and furnishing materials besides providing comfort of warmth. To suit the norms of the present national and international market, dyeing eri silk with natural dyes contributes to its value chain. The information on dyeing eri silk with natural dyes is very meager and requires to be established. New source such as Allamanda grandiflora was not used for dyeing textiles as per the available literature. Effort was made to standardise variables involved in extraction of the dyes and dyeing eri silk yarns. The standardisation procedures described under materials and methods were used and the evaluation was based on colour strength (K/S values) measured using colour flex spectrophotometer. Among the three mordanting methods, Pre mordanting method exhibited better results compare with simultaneous and post mordanted samples. Among the five mordants, alum and chitin mordanted samples exhibited good fastness followed by tartaric acid, ferrous sulphate and stannous chloride mordanted samples.
Optimisation of sperm cryopreservation protocol for Asian stinging catfish Heteropneustes fossilis (Bloch, 1794), to support hatchery seed production
Authors: Lal Kuldeep K , Barman Anindya S. , Puniya Peyush , Khare Praveen , Mohindra Vindhya , Singh Rajiv K. , Sah Rama S. , Majhi Sullip K. , Lal Bechan 
Published: November 2023

The present study experimentally evaluated different parameters such as extender composition, storage duration and egg to sperm ratio to optimise parameters for sperm cryopreservation in Asian stinging catfish Heteropneustes fossilis. Four extender compositions viz. Hanks Balanced Salt Solution (HBSS), Modified HBSS (M-HBSS), Modified HBSS with hen’s egg yolk (M-HBSS with EY) and European catfish extender were evaluated for sperm cryopreservation with dimethyl sulphoxide (DMSO) as cryoprotectant (10% v/v). The hatching rate was used as standard to evaluate the fertility of thawed sperm at different periods of storage (2, 270 and 668 days). After 2 days, extender M-HBSS exhibited highest hatching rate (49.06±2.67%) which was comparable to the control value (51.00±7.23%), followed by HBSS (42.76±32.0%), M-HBSS with EY (37.46±24.34%) and European catfish extender (29.47±25.61%), respectively. After 270 days with M-HBSS, hatching rate was 64.34±8.84% similar to the control; however, cryopreserved sperm with other extenders exhibited lower hatching rate as compared to control and M-HBSS. After 668 days, sperm cryopreserved in the extender M-HBSS, only yielded successful hatching. Results indicated that presence of egg yolk in the extender M-HBSS did not improve the performance of cryopreserved sperm. The successful hatching using cryopreserved sperm after 270 and 668 days of storage indicates M-HBSS as a useful extender for sperm cryobanking and seed production of H. fossilis.
Keywords: Aquaculture, Cryopreservation, Cryoprotectant, Dimethyl sulphoxide, Extender, Hanks Balanced Salt Solution, Hatching rate
Lava planets interior dynamics govern the
long-term evolution of their magma oceans
Authors:   Charles-Edouard Boukar&#x00E9, Lemasquerier Daphné , Cowan Nicolas , Samuel Henri , Badro James 
Published: November 2023

Abstract

Lava planets are rocky exoplanets that orbit so close to their host star that their day-side is hot enough to melt silicate rock. Their short orbital periods ensure that lava planets are tidally locked into synchronous rotation, with permanent day and night hemispheres. Such asymmetric magma oceans have no analogs in the Solar System and will exhibit novel fluid dynamics. Here we report numerical simulations of lava planet interiors showing that solid-liquid fractionation in the planetary interior has a major impact on the compositional structure and evolution of the planet. We explored two styles of dynamics that depend primarily on the interior thermal state : 1) a hot fully molten interior, and 2) a mostly solid interior with a shallow day-side magma ocean. In the hot interior scenario, the atmosphere reflects the planet's bulk silicate composition and the night-side crust is gravitationally unstable and constantly replenished. In the cool interior scenario, the distilled atmosphere will lack Na, K and FeO, and the night-side mantle is entirely solid, with a cold surface. These two end-member cases can be distinguished with observations from the James Webb Space Telescope, offering an avenue to probe the diversity of terrestrial exoplanet evolutions.
Auroral Ultraviolet Images for Prediction of the Auroral Electrojet Index
Authors: Li Jun , Tian Xinqin , Song LiuXing , Sheng Qinghong , Wang Bo , Cheng Wei 
Published: November 2023

Abstract
Solar wind parameters can effectively predict the component of the auroral current system directly driven by the solar wind, but cannot explain the dense westward electrojet formed through the unloading process of the magnetotail. However, auroral ultraviolet images (UVIs) can spatially map the entire variation process of auroral electrojets (AEs). In this paper, auroral UVIs are used for the prediction of AE index for the first time, and a grid feature extraction method based on correlation coefficient selection is proposed for the spatial mapping relationship between the latitude and longitude distribution characteristics of auroral power (AP) and the AE index. In terms of the prediction algorithm, we use the extreme learning machine (ELM) network, which has strong generalization ability, and compare it with the generalized regression neural network (GRNN) and fully convolutional network (FCN). The experimental results show that the method of predicting AE index by auroral UVI image is feasible, and the root mean square error of the prediction results exceeds the expected accuracy, reaching 8.97%. The study also shows that the grid feature extraction method greatly improves the accuracy of ELM network in predicting AE index, and it is also applicable to other prediction networks. The OS_ELM strategy can further reduce the prediction error by about 1.5%, and it tends to saturate with the increase of input data volume.
Association of lung immune prognostic index with survival outcomes in patients with metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
Authors: Yamashita Shimpei , Hamamoto Shuzo , Furukawa Junya , Fujita Kazutoshi , Takahashi Masayuki , Miyake Makito , Ito Noriyuki , Iwamoto Hideto , Kohjimoto Yasuo , Hara Isao 
Published: November 2023

Abstract

Background
Lung immune prognostic index (LIPI) is based on derived neutrophil to lymphocyte ratio and lactate dehydrogenase level. LIPI has reported association with survival outcomes in patients with various malignancies undergoing treatment with immune checkpoint inhibitors. However, the prognostic impact of pre-treatment LIPI in patients with metastatic renal cell carcinoma receiving nivolumab plus ipilimumab treatment remains unclear. This study examines the association between LIPI and outcomes in this setting.
Methods
We retrospectively evaluated 156 patients with metastatic renal cell carcinoma treated with nivolumab plus ipilimumab at eight institutions. We assessed the associations between pre-treatment LIPI and survival outcomes including progression-free survival (PFS), second progression-free survival (PFS2), cancer-specific survival (CSS) and overall survival.
Results
Patients were classified into good (n = 84, 54%), intermediate (n = 52, 33%) and poor (n = 20, 13%) LIPI groups. PFS did not significantly differ between LIPI groups, but there was significant difference in PFS2, CSS and overall survival. In multivariable Cox proportional hazard analyses, high pre-treatment LIPI was a significant predictor of poor PFS2 (vs. good group, intermediate group: P = 0.01 and poor group: P = 0.04) and poor overall survival (vs. good group, intermediate group: P = 0.01 and poor group: P < 0.01). Moreover, the patients with poor LIPI had significantly poorer CSS than those with good LIPI (P < 0.01).
Conclusions
High pre-treatment LIPI is suggested by our results to be a significant independent predictor of poor prognosis in patients receiving nivolumab plus ipilimumab for metastatic renal cell carcinoma.
Ageism and ageing anxiety in Egypt: a cross-sectional study
Authors: Abdelkadera Alaa S.E. , Elbayar Rana , Ashour Aya , Alwerdani Mariam M. , Ansary Abdallah , Hashish Sara , Ashour Ayat 
Published: November 2023

Abstract

Background
Ageism, and ageing anxiety are obstacles to health equity in the community. This study aims to assess ageism and ageing anxiety in Egypt and to elaborate on the related individual factors. Additionally, it explores the relationship between ageism and ageing anxiety.
Method
We conducted a cross-sectional online survey on 359 adult Egyptians using a predesigned questionnaire to assess socio-demographic factors, the Fabroni Scale on Ageism (FSA), the Ageing Anxiety Scale (AAS), and one question about contact with older adults.
Results
The mean total score of ageism was 72.79 (± 6.3 SD) while the mean total score of anxiety of ageing was 54.33 (± 8.83 SD). A significant positive correlation was found between ageism and ageing anxiety (r = 0.248, p = 0.000). Lower income is associated with higher ageism and ageing anxiety scores (p = 0.006 & 0.036 respectively) while frequent contact with older adults was associated with lower ageism and ageing anxiety scores (p = 0.000 for both). Participants who were single, not working, and reported poor religiosity had higher ageing anxiety scores (p = 0.009, 0.001, & 0.001 respectively).
Conclusion
Individual factors related to ageism and ageing anxiety in the Egyptian population were explored. Those who interact more with older adults exhibit a more favorable attitude toward old age and less anxiety. Ageism correlates positively with ageing anxiety. Additionally, individuals with lower income, single, not working, and reported poor religiosity tend to experience heightened ageing anxiety. Education about the ageing process could help reduce anxiety and stereotypes against ageing.
Regulation of apoptotic pathways by expression of AtBAG4 gene in Rasthali (AAB) banana induces effective containment of Fusarium oxysporum f. sp cubense (FOC)
Authors: Umesha M - , Sunisha C , Chandrashekar N , R Usharani T , - Sowmya H. D , S Sriram 
Published: November 2023

Abstract

Fusarium oxysporum f sp cubense (FOC) is fatal disease in banana limiting banana growers from attaining its potential yields across the globe. In the present study Rasthali (AAB), banana cultivar was transformed with Arabidopsis thaliana BAG4 gene (Bcl-2 associated athanogene) to modulate cell death pathways for probable induction of resistance against this deadly fungal pathogen. Stable transgenic plants were derived from transforming the embryogenic cells derived from immature male floral buds. Southern blotting and real time PCR confirmed integration and expression of the gene cassette respectively. Stable transgenic banana lines were selected from a number of transformation events based on the copy number and vigorous growth. Root challenge bioassay was performed with FOC mycelial extracts to derive disease severity index. Tolerant lines were micropropagated and analyzed for enzyme assays of super oxide dismutase and peroxidase. DNA fragmentation was not observed in stable transformants after FOC infection as confirmed by TUNEL assay. Transgenic AtBAG4 Rasthali plants effectively contained the infection processes and exhibited tolerance to FOC (Race 1). AtBAG4 mediated induction of resistance against FOC serves as a sustainable option for integrated Fusarium wilt management.