bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐associated chronic hepatitis in Cavalier King Charles spaniels
Authors: Nivy Ran , Kuzi Sharon , Swinburne June , Constantino‐Casas Fernando , Gajanayake Isuru , Bruchim Yaron , Berkowitz Asaf , Watson Penny 
Published: November 2023

AbstractBackgroundCopper‐associated chronic hepatitis (CuCH) is poorly characterised in Cavalier King Charles spaniels (CKCS).MethodsHepatic copper accumulation was qualitatively and quantitatively assessed, and blood samples were used for genetic testing to screen for known CuCH‐associated genetic variants.ResultsThe study included 13 CKCS with CuCH and eight unaffected controls. Increased transaminase activities, elevated biliary enzyme concentrations and portal hypertension were documented in 100%, 73% and 38% of dogs with CuCH, respectively. Five dogs had three or more abnormalities in measures of liver function. All 11 dogs with CuCh that underwent genetic testing were homozygous negative for the COMMD1 deletion and ATP7A variant but homozygous positive (n = 7) or heterozygous (n = 4) for the ATP7B variant. Liver histology often demonstrated marked architectural distortion by severe, bridging fibrosis and regenerative nodules with lymphoplasmacytic inflammation. Centrilobular copper accumulation characterised early cases with minimal fibrosis. When fibrosis was significant, copper was often differentially concentrated within regenerative nodules. Chelation therapy resolved laboratory derangements and portal hypertension in five of seven dogs. Of the 7 non‐surviving dogs with CuCH, 6 had not received chelation therapy.LimitationsLimitations include a small cohort size and the lack of pedigree analyses to corroborate heritability.ConclusionsCuCH should be considered in CKCS with suspected liver disease. Long‐term prognosis seems favourable in dogs receiving chelation therapy, notwithstanding the presence of previously reported negative prognostic markers.
Seaweed as climate mitigation solution: Categorizing and reflecting on four climate mitigation pathways
Authors: van den Burg Sander W. K. , Koch Sophie J. I. , Poelman Marnix , Veraart Jeroen , Selnes Trond , Foekema Edwin M. , Lansbergen Romy 
Published: November 2023

AbstractGlobal concerns about climate change were once again expressed at the COP27 in Sharm El‐Sheikh. Seaweed is frequently presented as a solution for climate mitigation. For a proper appraisal of its contribution to mitigating climate change, it is necessary to distinguish between, and critically scrutinize, the various pathways seaweed‐based climate mitigations can take. This article identifies four different climate mitigation pathways and critically reflects on each. First, carbon sequestration, occurring when grown seaweed is left in the seas or, second, purposefully sunk. Third, carbon emission reduction, resulting when seaweed‐based products replace products with a higher carbon footprint, either fossil based products or other organic material. Fourth, carbon emission avoidance, taking place when seaweed products are used to avoid greenhouse gas emissions in other production processes. Each of these pathways requires specific methods to quantify their magnitude and comes with critical questions to ask. The sequestration pathway requires monitoring of net carbon production and the amount of carbon that is eventually exported to the deep sea. Pathways 3 and 4 require Life Cycle Assessment and/or Carbon Footprint with system boundaries set to include the production system itself and installation thereof. We propose an unequivocal categorization in a belief that confusion on the benefits of seaweed will eventually impede development of seaweed‐based solutions.This article is categorized under:
The Carbon Economy and Climate Mitigation > Benefits of Mitigation
Receptor for advanced glycation end‐products: Biological significance and imaging applications
Authors: Dobrucki Iwona T. , Miskalis Angelo , Nelappana Michael , Applegate Catherine , Wozniak Marcin , Czerwinski Andrzej , Kalinowski Leszek , Dobrucki Lawrence W. 
Published: November 2023

AbstractThe receptor for advanced glycation end‐products (RAGE or AGER) is a transmembrane, immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse range of endo‐ and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such as reactive nitric oxide and oxygen species, cell proliferation, and immunoinflammatory processes. The involvement of RAGE in the pathogenesis of disorders such as diabetes, inflammation, tumor progression, and endothelial dysfunction is dictated by the accumulation of advanced glycation end‐products (AGEs) at pathologic states leading to sustained RAGE upregulation. The involvement of RAGE and its ligands in numerous pathologies and diseases makes RAGE an interesting target for therapy focused on the modulation of both RAGE expression or activation and the production or exogenous administration of AGEs. Despite the known role that the RAGE/AGE axis plays in multiple disease states, there remains an urgent need to develop noninvasive, molecular imaging approaches that can accurately quantify RAGE levels in vivo that will aid in the validation of RAGE and its ligands as biomarkers and therapeutic targets.This article is categorized under:
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Diagnostic Tools > Biosensing
Near complete quadriceps tendon healing 2 years following harvest in anterior cruciate ligament reconstruction
Authors: Inoue Jumpei , Dadoo Sahil , Nukuto Koji , Özbek Emre Anil , Lesniak Bryson P. , Sprague Andrew L. , Irrgang James J. , Musahl Volker 
Published: November 2023

AbstractPurposeDespite the recent increase in the use of quadriceps tendon (QT) autograft in anterior cruciate ligament reconstruction (ACLR); however, there remains a paucity of literature evaluating the postoperative morphology of the QT. The present study aimed to determine the postoperative morphologic change of the QT at a minimum of 2 years following harvesting during ACLR.MethodsPatients who underwent ACLR with QT autograft and underwent magnetic resonance imaging (MRI) at a minimum of 2 years following harvesting were retrospectively included in the study. The anterior‐to‐posterior (A–P) thickness, medial‐to‐lateral (M–L) width, cross‐sectional area (CSA), and signal/noise quotient (SNQ) of the QT were assessed at 5 mm, 15 mm, and 30 mm proximal to the superior pole of the patella on MRI. The CSA was adjusted by the angle between the QT and the plane of the axial cut based on a cosine function (adjusted CSA). The A–P thickness, M–L width, adjusted CSA, and SNQ were compared pre‐ and postoperatively. In addition, defects or scar tissue formation in the harvest site were investigated on postoperative MRI.ResultsThirty patients were recruited for the study. The mean duration between postoperative MRI and surgery was 2.8 ± 1.1 years. The mean A–P thickness was 10.3% and 11.9% larger postoperatively at 5 mm and 15 mm, respectively. The mean M–L width was 7.3% and 6.5% smaller postoperatively at 5 mm and 15 mm, respectively. There were no significant differences in the adjusted CSA between pre‐ and post‐operative states (275.7 ± 71.6 mm2 vs. 286.7 ± 91.8 mm2, n.s.). There was no significant difference in the postoperative change in the SNQ of the QT at all assessment locations. Defect or scar tissue formation at the harvest site was observed in 4 cases (13.3%), and 5 cases (16.6%), respectively.ConclusionAt a minimum of 2 years following QT harvest during ACLR, the QT became slightly thicker and narrower (approximately 11% and 7%, respectively). While the current study demonstrates that QT re‐harvesting can be considered due to nearly normalized tendon morphology, future histological and biomechanical studies are required to determine the re‐harvesting potential of the QT.Level of evidenceIV.
The accessory heads of the quadriceps femoris muscle may affect the layering of the quadriceps tendon and potential graft harvest lengths
Authors: Olewnik Łukasz , Zielinska Nicol , Aragones Paloma , Ruzik Kacper , Paulsen Friedrich , Borowski Andrzej , LaPrade Robert F. 
Published: November 2023

AbstractPurposeThe aim of the study was to assess the quadriceps femoris system for the presence of additional layers.MethodsOne hundred and twenty‐eight lower limbs fixed in 10% formalin were examined.ResultsFive types of quadriceps tendon layering were found based on the accessory heads of the quadriceps muscle. Type I (55%)—represented by four heads and four layers, and it was something new because standard orthopaedic textbooks described quadriceps tendon as a structure composed of only three layers. Type II (27.4%)—the first four layers were the same as in Type 1, but the accessory tendon of the fifth head of the quadriceps femoris muscle had the deepest attachments. Type III (10.9%)—this type included 6 heads of quadriceps femoris. It consisted of five layers. Type IV (3.1%)—this type included 7 quadriceps femoris heads. This type consisted of only four layers. Type V (3.1%)—this type included 8 heads of the quadriceps femoris heads. This type consist of 5 layers.ConclusionThe findings of this study provide a detailed anatomy of the quadriceps tendon including the accessory tendons of the accessory heads of the quadriceps tendon. The accessory heads of the quadriceps femoris muscle contribute to the layering of the quadriceps tendon. The second conclusion of this study is the development of safe distances depending on the types. Not all types are perfect for harvesting—Type IV seems to be the safest type, in turn Type V the most dangerous.
Bochner Laplacian and Bergman kernel expansion of semipositive line bundles on a Riemann surface
Authors: Marinescu George , Savale Nikhil 
Published: November 2023

AbstractWe generalize the results of Montgomery (Commun Math Phys 168:651–675, 1995) for the Bochner Laplacian on high tensor powers of a line bundle. When specialized to Riemann surfaces, this leads to the Bergman kernel expansion for semipositive line bundles whose curvature vanishes at finite order. The proof exploits the relation of the Bochner Laplacian on tensor powers with the sub-Riemannian (sR) Laplacian.
CD23-positive, BCL2-Rearrangement-negative Keimzentrumslymphome
Authors: Menter Thomas , Quintanilla-Martinez Leticia 
Published: November 2023

ZusammenfassungIm Rahmen der Erkenntnis, dass die Gruppe der follikulären Lymphome als sehr heterogen anzusehen ist, wurde in den letzten Jahren eine Gruppe follikulärer Lymphome abgegrenzt, die sich durch ein oft diffuses Wachstum (ohne Ausbildung follikulärer Strukturen) sowie Expression von CD23 in den Lymphomzellen und das Fehlen der klassischen BCL2-Translokation auszeichnete. Weitere Merkmale sind eine bevorzugte inguinale Lokalisation der Lymphome sowie ein lokalisiertes Stadium mit einer guten Prognose. Genetisch zeichnet sich diese Lymphomgruppe durch eine hohe Rate an STAT6- beziehungsweise SOCS1-Mutationen aus.Die ICC-Klassifikation trug dieser Entwicklung durch die Einführung der provisorischen Entität „CD23-positives, BCL2-Rearrangement-negatives Keimzentrumslymphom“ Rechnung. Weitere Studien müssen nun zeigen, wie genau sich diese Entität definieren lässt (Kombination aus Morphologie, immunhistochemischem Phänotyp, Fokus auf genetische Alterationen), um so den Weg hin zu einer einheitlichen Klassifikation und auch einer besseren klinischen Charakterisierung dieser Fälle – insbesondere auch im Hinblick auf die möglichen therapeutischen Optionen – zu ermöglichen.
Influence of water layer thickness on crater volume for nanosecond pulsed laser ablation of stainless steel
Authors: van der Linden S. , Hagmeijer R. , Römer G. R. B. E. 
Published: November 2023

AbstractUnder water laser ablation is a surface texturization method used to form micrometer-sized surface structures. Plasma confinement and cavitation bubble evolution play a critical role during the ablation process and their influence on material removal is strongly tied to liquid layer thickness. To influence the effects of these processes, such that material removal is at its maximum, an optimal layer thickness was found for various laser parameters. Specifically, for nanosecond pulsed laser ablation of stainless steel, however, the relation between layer thickness and volume removal is still unknown. Here, we show the relation between water layer thickness and removed material volume for a nanosecond pulsed laser. Results reveal that volume removal is at its maximum for a 1 mm water layer and drops by a factor of 2 when the layer thickness is increased to 2 mm. A further increase of layer thickness to 3 up to 10 mm shows a negligible effect on volume removal and removed volume amounts are shown to be similar to those obtained in ambient air in this water layer thickness range. This trend echo’s results obtained for nanosecond pulsed silicon ablation. The obtained results identify processing conditions which allow for faster and therefore more cost efficient texturization of stainless steel surfaces in the future.
Pleural drainage vs video-assisted thoracoscopic debridement in children affected by pleural empyema
Authors: Ratta Alberto , Nascimben Francesca , Angotti Rossella , Todesco Camilla , Carlini Veronica , Fusi Giulia , De Biagi Lorenzo , Straziuso Simona , Italiano Francesco , Domenichelli Vincenzo , Messina Mario , Molinaro Francesco 
Published: November 2023

Abstract
Background
Both thoracic drainage and video-assisted thoracic surgery (VATS) are available treatment for pleural empyema in pediatric patients.

Materials and methods
This retrospective multicenter study includes pediatric patients affected by pleural empyema treated from 2004 to 2021 at two Italian centers. Patients were divided in G1 (traditional approach) and G2 (VATS). Demographic and recovery data, laboratory tests, imaging, surgical findings, post-operative management and follow-up were analyzed.

Results
70 patients with a mean age of 4.8 years were included; 12 (17.1%) in G1 and 58 (82.9%) in G2. Median surgical time was 45 min in G1, 90 in G2 (p < 0.05). Mean duration of thoracic drainage was 7.3 days in G1, 6.2 in G2 (p > 0.05). Patients became afebrile after a mean of 6.4 days G1, 3.9 in G2 (p < 0.05). Mean duration of antibiotic therapy was 27.8 days in G1, 25 in G2 (p < 0.05). Mean duration of postoperative hospital stay was 16 days in G1, 12.1 in G2 (p < 0.05). There were 4 cases (33.3%) of postoperative complications in G1, 17 (29.3%) in G2 (p > 0.05). 2 (16.7%) patients of G1 needed a redosurgery with VATS, 1 (1.7%) in G2.

Conclusions
VATS is an effective and safe procedure in treatment of Pleural Empyema in children: it is associated to reduction of chest tube drainage, duration of fever, hospital stay, time of antibiotic therapy and recurrence rate.
Different techniques of adenoidectomy and its impact on middle ear pressure: a randomized controlled study
Authors: Seleim Ahmed Mohamed , Elsamnody Ahmed Nabil , Amer Ahmed Fawzy 
Published: November 2023

Abstract
Objectives
The aim of this work is to compare between different techniques of adenoidectomy: endoscopic microdebrider-assisted, coblation and conventional adenoidectomy and its effect on middle ear pressure.

Background
Adenoidectomy, either alone or with tonsillectomy, is considered among the most performed procedures in pediatric otorhinolaryngology. This procedure usually related to the Eustachian tube function and middle ear status. Eustachian tube dysfunction is mainly caused by mechanical obstruction of the tubal orifice, insufficient swallowing and inflammation in the nasopharyngeal mucosa.

Methods
This prospective randomized study was conducted on 90 patients with symptomatic adenoid hypertrophy confirmed by nasopharyngeal X-ray and endoscopic grading preoperatively. Patients were admitted at Otorhinolaryngology department of our institute during the period from January 2022 to January 2023. They were divided into three groups that were operated either by conventional (Group I), endoscopic microdebrider (Group II), or coblation technique (Group III). Each group was assessed through the audiometric parameters plus postoperative bleeding, and VAS results for pain score and postoperative endoscopic grading for adenoid recurrence.

Results
Mean age in group A was 9.03 years and in group B was 8.99 years and was 8.99 years in group C with insignificant differences between three groups. There is significant improvement of tympanographic results comparing all groups of the patients at 6 months postoperatively. There is significant relation between the mean VAS comparing preoperative and postoperative results.

Conclusion
There are better results in tympanographic data at conventional adenoidectomy versus other techniques. However, there are also better postoperative results after either coblation or endoscopic microdebrider adenoidectomy over the conventional technique.
Outcomes of cochlear implantation in Usher syndrome: a systematic review
Authors: Cornwall Hannah Louisa , Lam Chon Meng , Chaudhry Daoud , Muzaffar Jameel , Monksfield Peter , Bance Manohar L. 
Published: November 2023

Abstract
Purpose
This study is a systematic review of the literature which seeks to evaluate auditory and quality of life (QOL) outcomes of cochlear implantation in patients with Usher syndrome.

Methods
Systematic review of studies indexed in Medline via PubMed, Ovid EMBASE, Web of Science, CENTRAL and clinicaltrials.gov was performed up to March 9th 2022, conducted in accordance with the PRISMA statement. Patient demographics, comorbidity, details of cochlear implantation, auditory, and QOL outcomes were extracted and summarized.

Results
33 studies reported over 217 cochlear implants in 187 patients with Usher syndrome, comprising subtypes 1 (56 patients), 2 (9 patients), 3 (23 patients), and not specified (99 patients). Auditory outcomes included improved sound detection, speech perception, and speech intelligibility. QOL outcomes were reported for 75 patients, with benefit reported in the majority.

Conclusions
Many patients with Usher syndrome develop improved auditory outcomes after cochlear implantation with early implantation being an important factor.
Cutting-edge technology and automation in the pathology laboratory
Authors: Munari Enrico , Scarpa Aldo , Cima Luca , Pozzi Matteo , Pagni Fabio , Vasuri Francesco , Marletta Stefano , Dei Tos Angelo Paolo , Eccher Albino 
Published: November 2023

AbstractOne of the goals of pathology is to standardize laboratory practices to increase the precision and effectiveness of diagnostic testing, which will ultimately enhance patient care and results. Standardization is crucial in the domains of tissue processing, analysis, and reporting. To enhance diagnostic testing, innovative technologies are also being created and put into use. Furthermore, although problems like algorithm training and data privacy issues still need to be resolved, digital pathology and artificial intelligence are emerging in a structured manner. Overall, for the field of pathology to advance and for patient care to be improved, standard laboratory practices and innovative technologies must be adopted. In this paper, we describe the state-of-the-art of automation in pathology laboratories in order to lead technological progress and evolution. By anticipating laboratory needs and demands, the aim is to inspire innovation tools and processes as positively transformative support for operators, organizations, and patients.
Thermodynamically consistent effective stress formulation for unsaturated soils across a wide range of soil saturation
Authors: Ghorbani Javad , Kodikara Jayantha 
Published: November 2023

AbstractWe outline an extension of Biot’s theory of dynamic wave propagation in fluid-saturated media, which can be used to model dynamic soil-structure interaction in frictionless conditions across a wide range of soil saturation levels. In this regard, we present a comprehensive analysis of experimental evidence, the thermodynamic, and the theoretical basis of using the degree of saturation as Bishop’s parameter in unsaturated soils. The analysis highlights the limitations of using this parameter to accurately model unsaturated soil behaviour, particularly as the soil approaches dryness. Based on the analysis, a new definition of effective stress is proposed, and the associated work-conjugate pairs are identified. Recommendations are made for constitutive modelling using the new definition of effective stress. Finally, we introduce a fully coupled finite element contact model that utilises the new effective stress definition. Through numerical examples, we demonstrate the model’s capability to control the vanishing capillary effect on soil-structure interaction as the soil dries.
Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Authors: Neumayr Tara M. , Bayrakci Benan , Chanchlani Rahul , Deep Akash , Morgan Jolyn , Arikan Ayse Akcan , Basu Rajit K. , Goldstein Stuart L. , Askenazi David J. ,   The ADQI 26 workgroup, Alobaidi Rashid , Bagshaw Sean M. , Barhight Matthew , Barreto Erin , Ray O. N. Bignall , Bjornstad Erica , Brophy Patrick , Charlton Jennifer , Conroy Andrea L. , Devarajan Prasad , Dolan Kristin , Fuhrman Dana , Gist Katja M. , Gorga Stephen M. , Greenberg Jason H. , Hasson Denise , Heydari Emma , Iyengar Arpana , Jetton Jennifer , Krawczeski Catherine , Meigs Leslie , Menon Shina , Morgan Catherine , Mottes Theresa , Ricci Zaccaria , Selewski David T. , Soranno Danielle , Stanski Natalja , Starr Michelle , Sutherland Scott M. , Symons Jordan , Tavares Marcelo , Vega Molly , Zappitelli Michael , Ronco Claudio , Mehta Ravindra L. , Kellum John , Ostermann Marlies 
Published: November 2023

AbstractPediatric acute kidney support therapy (paKST) programs aim to reliably provide safe, effective, and timely extracorporeal supportive care for acutely and critically ill pediatric patients with acute kidney injury (AKI), fluid and electrolyte derangements, and/or toxin accumulation with a goal of improving both hospital-based and lifelong outcomes. Little is known about optimal ways to configure paKST teams and programs, pediatric-specific aspects of delivering high-quality paKST, strategies for transitioning from acute continuous modes of paKST to facilitate rehabilitation, or providing effective short- and long-term follow-up. As part of the 26th Acute Disease Quality Initiative Conference, the first to focus on a pediatric population, we summarize here the current state of knowledge in paKST programs and technology, identify key knowledge gaps in the field, and propose a framework for current best practices and future research in paKST.
Necessary Codimension One Components of the Projection of the Jacobian Blow-Up
Authors: Massey David B. 
Published: November 2023

AbstractFor a complex analytic function, the exceptional divisor of the jacobian blow-up is of great importance. In this short paper, we show what a lemma from the thesis of Lazarsfeld tells one about the structure of the projections of this exceptional divisor into the base space.