bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally invasive surgery for adrenal masses in children: results of a bi-centric survey and Literature review.
Authors: Nascimben Francesca , Lachkar Amane , Becmeur Francois , Molinaro Francesco , Angotti Rossella , Andolfi Ciro , Geiss Stephan , Talon Isabelle 
Published: January 2024

Abstract
Background
Minimally invasive surgery for adrenal pathologies in children is still developing because of the low incidence of adrenal masses in pediatric population and the discrepancy between the size of the mass and the child’s one. In Literature there are no any guidelines about the use of laparoscopic andrenalectomy in children. The aim of this study is to evaluate the outcomes of minimally invasive surgery through a bi-center data analysis in order to propose a standardized protocol.
Materials and methods
Children who underwent minimally invasive adrenalectomy between 2000 and 2020 performed by two expert Pediatric surgeons at two European departments of Pediatric Surgery were included in this study. Data were collected and analyzed using X-square, Fisher tests, multiple regression model.
Results
34 patients (38 adrenal masse)s were included. Mean age was 52 months 3–176]. Median lesion diameter was 60 mm [40-125mm]. Histological examination revealed 24 neuroblastomas, 11 pheochromocytomas, 1 teratoma, 1 adrenal cyst and 1 Myelolipoma. Laterality was 52.6% left, 36.8% right and 10.5% bilateral. Surgical access was trans-peritoneal in all patients. Mean operative time was 108 min for unilateral lesions and 270 min for bilateral ones. Mean hospital stay was 4.4 days. No major intra operative complications were observed. 21.05% neuroblastomas were preventively approached with a laparoscopic access and were converted to open surgery. Median follow-up was 88 months [24–264]. 4 patients affected by neuroblastoma reported metastatic dissemination and 3 died.
Conclusions
Pediatric minimally invasive adrenalectomy was a safe and effective procedure, it allows surgeons to reduce the size of laparotomies starting the dissection of the masses and it has low rate of complication if we consider small masses. The only absolute contraindication is persistent IDRF for neuroblastomas. It should be considered the first-line treatment for selected adrenal masses in centers with good experience in laparoscopy.
Identification of Novel Inhibitors Against Glutamate Racemase of Klebsiella Pneumoniae Through Homology Modeling and Docking Studies
Authors: sharma Rajan Sharma rajan , Singh Rashmi Prabha Singh Dr. Rashmi Prabha 
Published: January 2024

Abstract
Klebsiella pneumoniae is a bacterium that gives rise to infections in humans as well as animals. It is found in the environment, including in soil and water, and can also be present in the human microbiome, particularly in the gastrointestinal tract. Klebsiella pneumoniae can lead to a range of illnesses, including pneumonia, infections of the urinary tract, and wound infections. It is more typically found in patients with compromised immune systems, such as those who are hospitalized, have underlying medical conditions, or are taking certain medications that suppress the immune system. Antibiotic-resistant strains of Klebsiella pneumoniae, such as those that are resistant to carbapenem antibiotics, have become a significant public health concern in recent years. These strains can be difficult to treat and can lead to severe infections and high mortality rates. MurI is an enzyme found in the bacterial species Klebsiella pneumoniae that is implicated in the production of peptidoglycan, a key component of the bacterial cell wall. Inhibiting the activity of MurI has been shown to be an effective technique to establish new antibiotics for the treatment of infections caused by K. pneumoniae. In this study, we used homology modeling and docking techniques to identify novel inhibitors of MurI. Homology modeling is a computational method that uses the structure of a similar protein to predict the structure of a target protein. Docking is a method that predicts how well a small molecule will fit into the active site of a protein. To identify potential inhibitors of MurI, we first built a homology model of the enzyme using the structure of a related protein as a template. We then used this model to perform docking studies with a large database of small molecules. The docking results allowed us to identify several compounds that had good binding affinity for the active site of MurI. We then performed further experiments to confirm the inhibitory activity of these compounds against MurI in vitro. Overall, our study demonstrates the utility of homology modeling and docking in the identification of novel inhibitors of MurI. These compounds may have the ability as new antibiotics for the treatment of Klebsiella pneumoniae infections.
Right patient to the right place: the impact of a 6-year regional trauma center-led prehospital trauma education program on patient outcomes
Authors: Choi Donghwan , Huh Yo , Kang Byung Hee , Kim Sora , Song Seoyoung , Jung Kyoungwon , Jung Hohyung 
Published: January 2024

Abstract
Background: In regional trauma systems, emergency medical service (EMS) providers render an important function by performing prehospital triage for severely injured patients and transporting them to regional trauma centers. Since 2016, a regional trauma center has been providing trauma surgeon-provided prehospital medical guidance for EMS providers through a trauma hotline to guide field triage, treatment, and transport. This study analyzedthe effects and clinical outcomes of a regional trauma center-led performance improvement program that followed closed-loop principles for EMS providers.
Methods: Data from the regional trauma center databases (2016–2021) were collected, and patients with trauma with an Injury Severity Score (ISS) >15 in the Gyeonggi province who were injured, regardless of whether they visited the trauma center directly or not, were included. After adjusting for severity and baseline demographics through propensity score matching, clinical outcomes were analyzed using logistic regression, and the results were expressed as relative risks with 95% confidence intervals (95% CIs).
Results: We included 3017 patients from the 6-year study period. Correct triage and undertriage were performed in 2528 and 489 patients, respectively. Prehospital medical directions and feedback were provided 432 times (32.1%) in 2016 and increased to 1505 times (96.8%) in 2021 (z=11.342, p<0.001). The undertriage rate decreased from 32.7% (n=55/168) to 6.3% (n=52/820) (z=−13.689, p<0.001), and the overall mortality decreased from 21.4% to 10% (z=−5.96, p<0.001). After propensity score matching, 484 correctly triaged and 484 undertriaged patients were identified for subgroup analyses. The in-hospital mortality of undertriaged and correctly triaged patients was 20.5% (n=99) and 12.6% (n=61), respectively. The relative risk (95% CI)for undertriaged over correctly-triaged patients regardingin-hospital mortality, length of intensive care unit (ICU) stay, and mechanical ventilation duration was 1.78 (1.26–2.52, p=0.001), 1.01 (1.00–1.02, p=0.052; mean ± standard deviation [SD] 12.2±20.2 vs. 10.0±13.5), and 1.01 (1.00–1.02, p=0.048, mean ± SD 7.2±17.9 vs. 5.2±10.9), respectively.
Conclusion: Undertriage was associated with increased in-hospital mortality, length of ICU stay, and mechanical ventilation duration. The closed-loop communication program for EMS providers improved the undertriage rate. Specifically, in the early stages of regional trauma-system development, the trauma center-led trauma hotline feedback and case-based education programs can be effective models to facilitate prehospital patient triage and centralization of patients with severe trauma to trauma centers.
Direct observation as data-collection method: Application in a commercial forensic interview
Authors: Graan Constant van , Roos Vera , Katjene Matthews 
Published: January 2024

Abstract
In applying direct observation to obtain data, few researchers in the field of commercial forensic interviewing (CFI) have to date focused on the design and implementation of direct observation and descriptive analysis. Direct observations are useful for collecting data, due to the sensitive nature of a commercial forensic interview (CFI) involving Commercial Forensic Practitioners (FPs) and interviewees. The aim of this study is twofold: First, develop an observational checklist. Second, to apply it in a CFI to document direct observation of the interactional style of FPs, interactions, and relational dynamics. A descriptive analysis checklist was developed, drawing on interview techniques previously identified as permissible in a South African legal context and developed by applying directed content analysis. Two observers, FPs trained as academic researchers, independently documented their observations in the CFI context. The observers’ responses yielded significant levels of consensus (≥ 80%), and the results demonstrated several relational qualities which successfully identify the FP’s interactional style; the relational dynamics at play during the interview (by observing the actions, impact, and reactions of the participants), and ineffective relational dynamics, which thwarted the goal of eliciting useful information. This study highlights the need for direct observation and contributes to the development of an effective observational checklist unique to the CFI context.
Development of a Canine Model for Chronic Heart Failure Treatment Using a Pacemaker-Compatible Vagus Nerve Stimulation Device
Authors: Hu Yuchi , Zhao Lulu , Dai Songyuan , Lu Yanzhou , Chen Liling , Lu Yanan , Li Hao , Huang Yimei , Li Chuanxin , Ma XUjuan , Zhao Ling , Hua Baotong 
Published: January 2024

Abstract
This present study aims to develop a vagus nerve stimulator compatible with a pacemaker to treat chronic heart failure(CHF) in a canine model, with the goal of alleviating side effects induced by Vagus Nerve Stimulation (VNS), such as bradycardia.Five dogs underwent rapid right ventricular pacing at a rate of 180–200 beats per minute for three months, and their clinical manifestations, electrocardiograms, echocardiography, and cardiac function were assessed. Subsequently, a canine model combining VNS with a pacemaker was established, and this combined system was continuously stimulated for one month. Electrocardiograms and program-controlled monitoring were observed after VNS implantation to evaluate its effectiveness.Each dog displayed clinical symptoms, encompassing reduced activity and wheezing. Echocardiography validated changes in both cardiac function and structure. Additionally, the electrocardiogram and programmable monitoring affirmed that treatment with VNS led to a reduction in heart rate. Subsequently, the pacemaker commenced operation post-monitoring, a development detectable by both the pacemaker and programmable monitoring. The establishment of a canine model integrating VNS with pacing confirmed the potential of a vagus nerve stimulator compatible with pacing to enhance the efficacy of standalone VNS.
Cefoxitin versus Cefepime for the Prevention of Perioperative Infection in Elderly Patients Undergoing Colorectal Cancer Surgery: A Retrospective Study
Authors: Liu Yangxi , Luo Yang , Xu Jing , Zhang Zaili , Shi Bisheng , Ni Xiaojun 
Published: January 2024

Abstract
Background
The optimal antibiotic prophylaxis in preventing perioperative infection in patients aged 70 who underwent colorectal cancer surgery of are unknown. We conducted a comparative analysis to evaluate the efficacy of cefoxitin and cefepime in preventing perioperative infections and assessed the inflammatory response to antibiotics during the perioperative period.
Methods
Patients over 70 years old and undergo surgery for colorectal cancer between January 2021 and June 2022 at the same ward of a tertiary teaching hospital in Shanghai, China were included. Demographic and clinical data were retrieved from hospital information system (HIS) to evaluate the body reaction of two antibiotic prophylaxis: patients in Group A received cefoxitin and in Group B accepted cefepime after surgery. Both antibiotics were intravenous 2000mg, two times daily, total 3 days. The effect of perioperative prevention was compared between two groups with any infection complications, hospital length of stay (HLOS), postoperative length of stay (POLS) and mortality during hospitalization.
Results
A total of 107 elderly patients (56 patients in Group A and 51 patients in Group B) with colorectal cancer were included. Two groups were similar in terms of tumor stage and other basic demographic. Patients received cefoxitin demonstrated lower infection complications (12.5% vs 13.7%, P = 0.851), among which surgical site infection (SSI) were most frequent complications in both groups (8.5% vs 9.8%, P = 0.877). However, patients with cefepime represented shorter HLOS (14.0 ± 4.7 days vs 13.9 ± 3.8 days, P = 0.912) and PLOS (9.4 ± 3.8 days vs 8.4 ± 2.1 days, P = 0.265). Additionally, the percentage of cluster of differentiation (CD) 4 + cell was significantly higher (29.2%±9.2 vs 46.5%±10.0, P = 0.001) and the percentage of CD8 + cell was statistical lower (26.1% [23.1, 34.4] vs 19.2% [15.5, 20.4], P = 0.004) in Group B compared to Group A at the third postoperative day. No death occurred in both groups.
Conclusion
Cefepime and cefoxitin both serve as useful prophylaxis to reduce infectious complications among elder patients underwent surgery for colorectal cancer. However, cefepime illustrated a more active inflammatory response and might enhance the body recovery in early post-operative rehabilitation.
Medication Adherence and Its Associated Factors among Kidney Transplant Patients in St. Paul’s Hospital Millennium Medical College
Authors: Derejie Meskerem Nimani , Dereje Erimas Nemani , Alemu Dirijit Mamo , Tesfay Yemane Gebremedhin , Banja Fufa Hunduma , Temie Negash Miniwye 
Published: January 2024

Abstract

Background: This study examines medication adherence among kidney transplant patients at St. Paul's Hospital in Addis Ababa, Ethiopia, focusing on the level of adherence and associated factors to immunosuppressant medicines.
Methods and Materials: A cross-sectional study was conducted on 270 patients from October 2021 to January 2022 using a structured questionnaire to be analyzed with SPSS version 26. The prevalence of medication adherence was computed, and a binary logistic regression was fitted to estimate the association. A 95% confidence interval and p-value <0.05 were used for statistical significance.
Results: The study found that 71.5% of kidney transplant patients were male, with a median age of 37 and a mean duration of 3.55 years. Medication adherence in post-kidney transplant patients was 81.9%. Being more than 5 years post-transplant and missing follow-up visits more than two times led to a 92.6% and 91.2% decrease in medication adherence respectively. Additionally, forgetfulness was associated with a 90.6% lower adherence level compared to drug unavailability and financial reasons.
Conclusion and recommendation: The study indicates that our patients exhibit higher medication adherence than WHO-measured levels, suggesting the need for healthcare providers to encourage this, especially for those above 5 years post-kidney transplant.
Effect of magma intrusion on pore structure and trace element migration of anthracite
Authors: Fu Xiang , Liu Xuan , Wu Qixuan , Xiao Bin , Fan Chaojun 
Published: January 2024

Abstract
Magma intrusion has an important influence on the physical and mechanical properties of coal and rock. In the area of magma intrusion, disasters such as gas outburst are prone to occur. Revealing its invasion law will be conducive to disaster management and energy development. For this purpose, changes in moisture, ash yield, volatile matter content, fixed carbon, mineral composition, major oxides, trace elements, and REE of coal under the thermal metamorphism of magma intrusion were analyzed. It is found that the moisture and volatile matter contents of the thermally affected coals in the mining face are generally lower than that of normal coals, while moisture and volatile matter contents are reduced towards to the magma intrusion contact. During magma intrusion, some minerals remain on the surface of the coal body, resulting in changes in the mineral composition of the coal body. The decrease in carbon atom net spacing, the increase in crystallite aggregation and ductility, and aromaticity in thermally affected coals have a positive impact on the improvement of coal metamorphism. Due to the influences of magmatic intrusion, the variation rules of major oxides in coal are different, and the closer to the magmatic intrusion zone, the easier the major oxides are to be depleted. However, magma intrusion will not lead to the loss of all major oxides in thermally affected coals, such as CaO and MnO contents are higher than unaffected coals. Most of the trace elements in the thermally affected coals of the No. 9 coal seam are depleted, while all of the elements Be, Cr, Ni, Tl, Pb, and U that are potentially hazardous to the environment are depleted. The contents of REE are low on the whole coalbasis, and the distribution pattern towards to magmatic intrusion shows a wide and gentle “ V ” curve with left high and right low, showing the characteristics of enrichment of LREE.
Non-detectable Patterns Hidden Withinsequences of Bits
Authors: Allen David , Luz Jose La , Salivia Guarionex , Hardwick Jonathan 
Published: January 2024

Abstract
In this paper we construct families of bit sequencesusing combinatorial methods. Each sequence is derived by connverting a collection of numbers encoding certain combinatorial numerics from objects exhibiting symmetry in various dimensions.Using the algorithms first described in [1] we show that the NIST testing suite described in publication 800-22 does not detect these symmetries hidden within these sequences.
Predictive effect of triglyceride-glucose index on No-Reflow Phenomenon in patients with type 2 diabetes mellitus and acute myocardial infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Ma Juan , Wang MoHan , Wu Peng , Ma Xueping , Chen Dapeng , Jia Shaobin , Yan Ning 
Published: January 2024

Abstract
Objective
Triglyceride glucose (TyG) index is considered as a new alternative marker of insulin resistance and a clinical predictor of type 2 diabetes mellitus (T2DM) combined with coronary artery disease. However, the prognostic value of TyG index on No-Reflow (NR) Phenomenon in T2DM patients with acute myocardial infarction (AMI) remains unclear.
Methods
In this retrospective study, 1683 patients with T2DM and AMI underwent primary percutaneous coronary intervention (PCI) were consecutively included between January 2014 and December 2019. The study population was divided into two groups as follows: Reflow (n = 1277) and No-reflow (n = 406) group. The TyG index was calculated as the ln [fasting triglycerides (mg/dL)×fasting plasma glucose (mg/ dL)/2].Multivariable logistic regression models and receiver-operating characteristic curve analysis were conducted to predict the possible risk of no-reflow. Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) were calculated to determine the ability of the TyG index to contribute to the baseline risk model.
Results
Multivariable logistic regression models revealed that the TyG index was positively associated with NR[OR,95%CI:5.03,(2.72,9.28),p༜0.001] in patients with T2DM and AMI. The area under the curve (AUC) of the TyG index predicting the occurrence of NR was [OR,95%CI:0.645 (95% CI 0.615–0.673; p < 0.001)], with the cut-off value of 8.98. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for NR [net reclassification improvement (NRI): 0.077(0.043to 0.111), integrated discrimination improvement (IDI): 0.070 (0.031to 0.108), all p < 0.001].
Conclusions
High TyG index was associated with an increased risk of no-reflow after PCI in AMI patients with T2DM. The TyG index may be a valid predictor of no-reflow phenomenon of patients with T2DM and AMI. Early recognition of no-reflow is critical to improve outcomes with AMI and T2DM patients.
Convective drying of chokeberry (Aronia melanocarpa Michx. Elliot) cv. ‘Viking’ and modeling
(Convective drying of chokeberry)
Authors: Unal Nafiye , Süslü Ahmet , Kulcu Recep , Dincer Cuneyt , İmirgi Eda Elif Yavuzlar , Ertekin Can 
Published: January 2024

Abstract
The effects of drying air temperatures (50, 60, 70 and 80oC) and velocities (0.5, 0.8, 1.2 m s− 1) used for the convective drying of chokeberry on fruit quality were quantified. In addition, the 11 different drying models were used to describe the drying kinetics of the chokeberry samples. The drying air temperature rise shortened the drying time from 2660 min at 50oC to 185 min at 80oC. Drying time was 220 min at the drying air velocity of 1.2 m s− 1. An increase in the temperature from 50 to 80oC and the air velocity from 0.5 m·s− 1 to 1.2 m·s− 1 enhanced fruit color quality index. All the drying treatments enriched the biochemical fruit content. 70oC and the air velocity between 0.5 m s− 1 and 1.2 m s− 1 achieved the highest antioxidant activity, total anthocyanin content and total phenolic content. Midilli et al. model exhibited the best fit to all experimental data (R2 ≥ 0.9978; χ2 ≤ 0.0003; RMSE ≤ 0.0161).
The Impact of Weight-loss Based Exercise Methods on Patients with Simple Obesity: A Comparative Study between Bicycle and Treadmill Training
Authors: Chen Peishun , Min Yu , Luo Yanjun , Zhang Wanrong 
Published: January 2024

Abstract
Objective It’s a comparative study between bicycle and treadmill groups to observe the effects of of weight-loss based exercise methods on patients with simple obesity, thus to provide a scientific basis for the healthy exercise methods to lose weight.
Methods 60 patients with simple obesity were randomly divided into two groups of 30: the bicycle group and the treadmill group. Both groups received high-intensity interval exercise training, power bicycle training andmoving treadmill training (MTT) were accepted respectively. Both groups received consecutive treatment for 12weeks, five times a week, and every single time lasted for 30minutes. Before and after treatment, the Body mass index (BMI), the knee’s articular cartilage volume was measured with magnetic resonance imaging (MRI)，the pain of knee was assessed with visual analogue scale (VAS). Before and after each training session, the local skin temperature of the knee was measured with an electronic thermometer.
Results After 12 weeks of treatment, the BMI was both decreased, the VAS and the local skin temperature of knee was increased significantly, the knee’s articular cartilage volume in the treadmill group was reduced significantly, while the above indicators in the bicycle group did not change significantly, and the difference between the two groups was statistically significant (p<0.001).
Conclusion Power bicycle training can avoid a decrease in the volume of knee joint cartilage, while MTT can easily lead to a decrease in the volume of knee joint cartilage, an increase in local skin temperature and pain of knee joint.