bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial
Authors: Kirkwood John M. , Del Vecchio Michele , Weber Jeffrey , Hoeller Christoph , Grob Jean-Jacques , Mohr Peter , Loquai Carmen , Dutriaux Caroline , Chiarion-Sileni Vanna , Mackiewicz Jacek , Rutkowski Piotr , Arenberger Petr , Quereux Gaelle , Meniawy Tarek M. , Ascierto Paolo A. , Menzies Alexander M. , Durani Piyush , Lobo Maurice , Campigotto Federico , Gastman Brian , Long Georgina V. 
Published: October 2023

AbstractPatients with resected stage IIB/C melanoma have high recurrence risk, similar to those with resected stage IIIA/B disease. The phase 3, double-blind CheckMate 76K trial assessed 790 patients with resected stage IIB/C melanoma randomized 2:1 (stratified by tumor category) to nivolumab 480 mg or placebo every 4 weeks for 12 months. The primary endpoint was investigator-assessed recurrence-free survival (RFS). Secondary endpoints included distant metastasis-free survival (DMFS) and safety. At 7.8 months of minimum follow-up, nivolumab significantly improved RFS versus placebo (hazard ratio (HR) = 0.42; 95% confidence interval (CI): 0.30–0.59; P < 0.0001), with 12-month RFS of 89.0% versus 79.4% and benefit observed across subgroups; DMFS was also improved (HR = 0.47; 95% CI: 0.30–0.72). Treatment-related grade 3/4 adverse events occurred in 10.3% (nivolumab) and 2.3% (placebo) of patients. One treatment-related death (0.2%) occurred with nivolumab. Nivolumab is an effective and generally well-tolerated adjuvant treatment in patients with resected stage IIB/C melanoma. ClinicalTrials.gov identifier: NCT04099251.
Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients
Authors: Soussou Souha , Jablaoui Amin , Mariaule Vincent , Kriaa Aicha , Boudaya Houda , Wysocka Magdalena , Amouri Ali , Gargouri Ali , Lesner Adam , Maguin Emmanuelle , Rhimi Moez 
Published: October 2023

AbstractSerine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients. While most of the studies focused on host proteases, the contribution of microbial proteases are poorly studied. In the present study, we report the analysis of proteolytic activities in fecal samples from the first Tunisian cohort of IBS-M patients and healthy individuals. We demonstrated, for the first time, that metalloproteases activities were fourfold higher in fecal samples of IBS patients compared to controls. Of interest, the functional characterization of serine protease activities revealed a 50-fold increase in trypsin-like activities and a threefold in both elastase- and cathepsin G-like activities. Remarkably, we also showed a fourfold increase in proteinase 3-like activity in the case of IBS. This study also provides insight into the alteration of gut microbiota and its potential role in proteolytic modulation in IBS. Our results stressed the impact of the disequilibrium of serine proteases, metalloproteases and gut microbiota in IBS and the need of the further characterization of these targets to set out new therapeutic approaches.
Chemically-stable flexible transparent electrode: gold-electrodeposited on embedded silver nanowires
Authors: Gholami Mostafa , Tajabadi Fariba , Taghavinia Nima , Moshfegh Alireza 
Published: October 2023

AbstractSilver nanowires (AgNWs) with a low diameter, high aspect ratio, stable suspension, and easy synthesis have recently attracted the optoelectronic industry as a low-cost alternative to indium tin oxide transparent conductive films. However, silver nanowires are not chemically stable, and their conductivity diminishes over time due to reactions with atmospheric components. This is a bottleneck for their wide industrial applications. In this study, we aim to address this issue by synthesizing silver nanowires with an average diameter of approximately 65 nm and a length of approximately 13 µm. The prepared Ag nanowires are then applied to fabricate transparent, flexible, and chemically stable conductive films. The fabrication includes spraying of silver nanowires suspension on a glass substrate followed by Dr. blade coating of polystyrene (PS) solution and delamination of the PS-AgNWs film. The resulting film exhibits an optimum sheet resistance of 24 Ω/□ and transmittance of 84%. To further enhance the stability of the transparent conductive film, the facial and scalable double pulse electrodeposition method is used for coating of gold on the exposed surface of the AgNWs embedded in PS. The final transparent film with gold coating demonstrates a remarkable stability under harsh conditions including long exposure to UV light and nitric acid solution. After 100 min of UV/Ozone treatment, the increase in sheet resistance of the optimal PS-AgNW@Au sample is 15.6 times lower than the samples without gold coating. In addition, the change in sheet resistance after 2000 bending cycles in the optimal PS-AgNW@Au electrode is measured and it showed an increase of only 22% of its initial sheet resistance indicating its good flexibility. The proposed electrode performs an excellent chemical stability, good conductivity, transparency, and flexibility that makes it a potential candidate for various optoelectronic devices.
Effect of alcohol on Brain-Derived Neurotrophic Factor (BDNF) blood levels: a systematic review and meta-analysis
Authors: Shafiee Arman , Jafarabady Kyana , Rafiei Mohammad Ali , Beiky Maryam , Seighali Niloofar , Golpayegani Golshid , Jalali Mehrsa , Soltani Abhari Faeze , Arabzadeh Bahri Razman , Safari Omid , Bakhtiyari Mahmood , Alirezaei Amirhesam 
Published: October 2023

AbstractBrain-Derived Neurotrophic Factor (BDNF) is a vital protein involved in neuronal development, survival, and plasticity. Alcohol consumption has been implicated in various neurocognitive deficits and neurodegenerative disorders. However, the impact of alcohol on BDNF blood levels remains unclear. This systematic review and meta-analysis aimed to investigate the effect of alcohol consumption on BDNF blood levels. A comprehensive search of electronic databases was conducted to identify relevant studies. Eligible studies were selected based on predefined inclusion criteria. Data extraction was performed, and methodological quality was assessed using appropriate tools. A meta-analysis was conducted to estimate the overall effect size of alcohol consumption on BDNF levels. A total of 25 studies met the inclusion criteria and were included in the final analysis. Alcohol use and BDNF blood levels were significantly correlated, according to the meta-analysis (p = 0.008). Overall, it was discovered that drinking alcohol significantly decreased BDNF levels (SMD: − 0.39; 95% CI: − 0.68 to − 0.10; I2: 93%). There was a non-significant trend suggesting that alcohol withdrawal might increase BDNF levels, with an SMD of 0.26 (95% CI: − 0.09 to 0.62; I2: 86%; p = 0.14). Subgroup analysis based on the source of BDNF demonstrated significant differences between the subgroups (p = 0.0008). No significant publication bias was observed. This study showed that alcohol consumption is associated with a significant decrease in BDNF blood levels. The findings suggest a negative impact of alcohol on BDNF levels regardless of alcohol dosage. Further studies are needed to strengthen the evidence and elucidate the underlying mechanisms.
Endotoxin removal therapy with Polymyxin B immobilized fiber column: a single center experience from EUPHAS2 registry
Authors: Forin Edoardo , Lorenzoni Giulia , Ferrer Ricard , De Cal Massimo , Zanella Monica , Marchionna Nicola , Gregori Dario , Forfori Francesco , Lorenzin Anna , Danzi Vinicio , Ronco Claudio , De Rosa Silvia 
Published: October 2023

AbstractAlthough the precise clinical indication for initiation of PMX-HA is widely debated in the literature, a proper patient selection and timing of treatment delivery might play a critical role in the clinical course of a specific subphenotype of septic shock (endotoxic shock). In light of this view, since 2019, we have introduced in our clinical practice a diagnostic-therapeutic flowchart to select patients that can benefit the most from the treatment proposed. In addition, we reported in this study our experience of PMX-HA in a cohort of critically ill patients admitted to our intensive care unit (ICU). We analyzed a single centre, retrospective, observational web-based database (extracted from the EUPHAS2 registry) of critically ill patients admitted to the ICU between January 2016 and May 2021 who were affected by endotoxic shock. Patients were divided according to the diagnostic-therapeutic flowchart in two groups: Pre-Flowchart (Pre-F) and Post-Flowchart (Post-F). From January 2016 to May 2021, 61 patients were treated with PMX-HA out of 531 patients diagnosed with septic shock and of these, fifty patients (82%) developed AKI during their ICU stay. The most common source of infection was secondary peritonitis (36%), followed by community-acquired pneumonia (29%). Fifty-five (90%) out of 61 patients received a second PMX-HA treatment, with a statistically significant difference between the two groups (78% of the Pre-F vs. 100% of the Post-F group, p = 0.005). In both groups, between T0 and T120, the Endotoxin Activity Assay (EAA) decreased, while the SOFA score, mean arterial pressure (MAP), and Vasoactive Inotropic Score (VIS) improved with no statistically significant difference. Furthermore, when performing a propensity score matching analysis to compare mortality between the two groups, statistically significant lower ICU and 90-day mortalities were observed in the Post-F group [p = 0.016]. Although in this experienced centre data registry, PMX-HA was associated with organ function recovery, hemodynamic improvement, and current EAA level reduction in critically ill patients with endotoxic shock. Following propensity score-matched analysis, ICU mortality and 90-day mortalities were lower in the diagnostic-therapeutic flowchart group when considering two temporal groups based on strict patient selection criteria and timing to achieve PMX. Further Randomised Control Trials focused on centre selection, adequate training and a flowchart of action when assessing extracorporeal blood purification use should be performed.
MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages
Authors: Cui Huachun , Banerjee Sami , Xie Na , Dey Tapan , Liu Rui-Ming , Sanders Yan Y. , Liu Gang 
Published: October 2023

AbstractActivation of the NLRP3 inflammasome is a two-step process: the priming and the activating. The priming step involves the induction of NLRP3 and pro-IL-1β, while the activating step leads to the full inflammasome activation triggered by a NLRP3 activator. Although mechanisms underlying the NLRP3 inflammasome activation have been increasingly clear, the regulation of this process remains incompletely understood. In this study, we find that LPS and Pseudomonas aeruginosa cause a rapid downregulation in MafB transcription in macrophages, which leads to a quick decline in the level of MafB protein because MafB is short-lived and constantly degraded by the ubiquitin/proteasome system. We find that MafB knockdown or knockout markedly enhances the NLRP3, but not the NLRP1, NLRC4, or AIM2, inflammasome activation in macrophages. Conversely, pharmacological induction of MafB diminishes the NLRP3 inflammasome activation. Mechanistically, we find that MafB sustains the expression of p62, a key mediator of autophagy/mitophagy. We find that MafB inhibits mitochondrial damage, and mitochondrial ROS production and DNA cytoplasmic release. Furthermore, we find that myeloid MafB deficient mice demonstrate increased systemic and lung IL-1β production in response to LPS treatment and P. aeruginosa infection and deficient lung P. aeruginosa clearance in vivo. In conclusion, our study demonstrates that MafB is an important negative regulator of the NLRP3 inflammasome. Our findings suggest that strategies elevating MafB may be effective to treat immune disorders due to excessive activation of the NLRP3 inflammasome.
Overcoming the Research–Practice Gap: Key Considerations for Speech-Language Pathologists Related to Multitiered Systems of Support
Authors: Sylvan Lesley 
Published: October 2023

Purpose:
This tutorial highlights the challenges and opportunities school-based speech-language pathologists (SLPs) face related to engagement with the multitiered systems of support (MTSS) framework in their public school work practices. It positions SLP involvement in MTSS as an area where a gap between research and practice exists and highlights key ways for SLPs to overcome barriers to support student success within this framework.

Method:
This tutorial provides a general description of the MTSS framework and highlights the immediate applicability of the framework to SLP school practices. Key considerations are offered for SLPs ready to take concrete steps related to implementing the MTSS framework. Hypothetical cases are used to illustrate how school-based SLPs can use these considerations to guide meaningful but realistic changes.

Results:

Ongoing concerns about the impact of the pandemic on student outcomes and growing awareness of systemic inequities in education are prompting SLPs to move beyond asking
if
they should be involved in MTSS to focusing on how they should be engaged with this framework. This tutorial provides five key considerations for SLPs to realistically deepen their engagement with MTSS and overcome the research–practice gap in this area.

Conclusion:
This tutorial provides a resource for SLPs to take concrete and immediate steps to support at-risk students through MTSS given the needs at this unique moment in time when concerns about learning loss and achievement gaps are front and center in public schools.
Fed‐SAD: A secure aggregation federated learning method for distributed short‐term load forecasting
Authors: Li Hexiao , Wu Sixing , Wang Ruiqi , Guo Yiguo , Li Jianbin 
Published: October 2023

AbstractThe distributed and privacy‐preserving attributes of fine‐grained smart grid data create obstacles to data sharing. As a result, federated learning emerges as an effective strategy for collaborative training in distributed load forecasting. However, poisoning attacks can interfere with training in the federated learning aggregation process, making it challenging to ensure the accuracy and safety of the global model in load forecasting. Therefore, the authors propose a secure aggregation federated learning method based on similarity and distance (Fed‐SAD) for distributed load forecasting. The server determines approximate global model parameters based on the similarity of the model parameters of the participants and aggregates the global model parameters using a distance‐based weighting method. Fed‐SAD effectively reduces the interference of poisoning attacks by securely aggregating models in short‐term load forecasting. Experimental results show that using the Fed‐SAD results in mean absolute percentage error (MAPE) reduction for certain participants by 19% on sign flipping attacks, MAPE reduction by 15% on additive noise attacks, and MAPE reduction by 4.5% without attack, compared to the Federated Average Aggregation algorithm. Furthermore, Fed‐SAD consistently maintains robustness and has excellent attack detection accuracy.
Hydrocarbon chemistry in the inner regions of planet-forming disks
Authors: Kanwar J. , Kamp I. , Woitke P. , Rab Ch. , Thi W. F. , Min M. 
Published: October 2023

Context. The analysis of the mid-infrared spectra helps understanding the composition of the gas in the inner, dense and warm terrestrial planet forming region of disks around young stars. ALMA has detected hydrocarbons in the outer regions of the planet forming disk and Spitzer detected C2H2 in the inner regions. JWST-MIRI provides high spectral resolution observations of C2H2 and a suite of more complex hydrocarbons are now reported. Interpreting the fluxes observed in the spectra is challenging and radiation thermo-chemical codes are needed to properly take into account the disk structure, radiative transfer, chemistry and thermal balance. Various disk physical parameters like the gas-to-dust ratio, dust evolution including radial drift, dust growth and settling can affect the fluxes observed in the mid-IR. Still, thermo-chemical disk models were not always successful in matching all observed molecular emission bands simultaneously.
Aims. The goal of this project is two-fold. Firstly, we analyse the warm carbon chemistry in the inner regions of the disk, namely within 10 au, to find pathways forming C2H2 potentially missing from the existing chemical networks. Secondly, we analyse the effect of the new chemistry on the line fluxes of acetylene.
Methods. We used the radiative thermo-chemical disk code called PRODIMO to expand the hydrocarbon chemistry that occurs in a typical standard T Tauri disks. We used the UMIST and the KIDA rate databases for collecting reactions for the species. We included a number of three-body and thermal decomposition reactions from the STAND2020 network. We also included isotopomers for the species that were present in the databases. The chemistry was then analysed in the regions that produce observable features in the mid-infrared spectra. We studied the effect of expanding the hydrocarbon chemistry on the mid-infrared spectra.
Results. Acetylene is formed via two pathways in the surface layers of disks: neutral-neutral and ion-neutral. They proceed via the hydrogenation of C or C+, respectively. Thus, the abundances of C, C+, H and H2 affect the formation of C2H2. Therefore, also the formation of H2 indirectly affects the abundance of acetylene. Chemisorbed H is more efficient in forming H2 compared to physisorbed H at warm temperatures and hence increases the abundance of C2H2.
Conclusions. We provide a new extended warm chemical network that considers up to eight carbon atom long species, while also taking into account different isotopomers and can form the building blocks of PAHs: C6H6. For a standard T Tauri disk with a canonical value of gas-to-dust mass, the line fluxes increase only by a factor of less than 2. JWST is now detecting hydrocarbons such as methane, acetylene, and C4H2 in disks with a high C/O ratio. Hence, this new extended warm hydrocarbon network will aid in interpreting the observed mid-infrared fluxes.
Knowledge sharing and innovation performance: a case study on the impact of organizational culture, structural capital, human resource management practices, and relational capital of real estate agents
Authors: Lee Chung-Chang , Yeh Wen-Chih , Yu Zheng , Luo Yuan-Chen 
Published: October 2023

AbstractThis study focused on the factors that influence innovation performance in housing agents. Based on a worldwide literature review on the topic of innovation performance, we defined relational capital, knowledge sharing at the individual level, and organizational culture, structural capital, and human resource management practices at the organizational level to carry out the analysis using hierarchical linear modeling. The survey subjects were housing agents in Kaohsiung City, Taiwan. A total of 1130 questionnaires were distributed to 113 agencies. Of a total of 444 collected surveys, 40 unanswered questionnaires were invalid and three with fewer than three answers were eliminated. The final number of valid questionnaires was 401. The response rate of effective questionnaires was 35.49%. The results show that organizational culture can indirectly affect innovation performance through knowledge sharing, indicating that there is a partial mediating effect. Structural capital can indirectly affect innovation performance through knowledge sharing, demonstrating a complete mediating effect. Relational capital can indirectly affect innovation performance through knowledge sharing, having a partial mediating effect. Human resource management practices did not have a confounding effect on innovation performance.
Charge carrier dynamics in conducting polymer PEDOT using ab initio molecular dynamics simulations
Authors: Zahabi Najmeh , Baryshnikov Glib , Linares Mathieu , Zozoulenko Igor 
Published: October 2023

As conducting polymers become increasingly important in electronic devices, understanding their charge transport is essential for material and device development. Various semi-empirical approaches have been used to describe temporal charge carrier dynamics in these materials, but there have yet to be any theoretical approaches utilizing ab initio molecular dynamics. In this work, we develop a computational technique based on ab initio Car–Parrinello molecular dynamics to trace charge carrier temporal motion in archetypical conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT). Particularly, we analyze charge dynamics in a single PEDOT chain and in two coupled chains with different degrees of coupling and study the effect of temperature. In our model we first initiate a positively charged polaron (compensated by a negative counterion) at one end of the chain, and subsequently displace the counterion to the other end of the chain and trace polaron dynamics in the system by monitoring bond length alternation in the PEDOT backbone and charge density distribution. We find that at low temperature (T = 1 K) the polaron distortion gradually disappears from its initial location and reappears near the new position of the counterion. At the room temperature (T = 300 K), we find that the distortions induced by polaron, and atomic vibrations are of the same magnitude, which makes tracking the polaron distortion challenging because it is hidden behind the temperature-induced vibrations. The novel approach developed in this work can be used to study polaron mobility along and between the chains, investigate charge transport in highly doped polymers, and explore other flexible polymers, including n-doped ones.
Character reference in Russian and Cypriot Greek by bilingual
children
Authors: Karpava Sviatlana 
Published: October 2023

Abstract
This study investigates the development of character reference by
bilingual Russian–Cypriot Greek children, in both Russian and
Cypriot Greek. In particular, it is focused on such referential
functions as character introduction, reintroduction and maintenance
in narrative production. Twenty-three bilingual Russian–Cypriot
Greek children (3–8 years old) participated in the study. Two
stories (card method of picture presentation), with a different
number of main characters (‘Cat’ story with four main characters and
‘Fox’ story with two main characters) and a different level of
cognitive complexity were used for narrative elicitation. Cypriot
Greek and Russian differ in terms of the way of encoding new/given
information and referential status of the character. Cypriot Greek
uses mainly local cues (definite vs. indefinite determiners), while
Russian uses global cues (word order, case marking). The results of
the study showed that bilingual children had a better performance,
use of indefinite NPs for character introduction and definite NPs
for character reintroduction in CG, but they had a better
performance for character maintenance and use of overt pronouns in
Russian. Story type, complexity and the number of the main
characters in the story influence the use of referential forms by
bilingual children, both in CG and in Russian.