bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEAD‐box helicase 1 inhibited CD8+ T cell antitumor activity by inducing PD‐L1 expression in hepatocellular carcinoma
Authors: Liu Junhao , Yang Ti , Luo Yurong , Ma Zengxin , Yu Zhitao , Zhang Lei , Liu Gai , Wen Jianfan , Lu Guankun , Zhang Guowei , Zhao Yujun , Luo Wang , Li Yanan , Yang Nengjia , Zhou Jiawei , Lu Yuhui , Chen Siliang , Zeng Xiancheng 
Published: January 2024

AbstractHepatocellular carcinoma (HCC) does not respond well to current treatments, even immune checkpoint inhibitors. PD‐L1 (programmed cell death ligand 1 or CD274 molecule)‐mediated immune escape of tumor cells may be a key factor affecting the efficacy of immune checkpoint inhibitor (ICI) therapy. However, the regulatory mechanisms of PD‐L1 expression and immune escape require further exploration. Here, we observed that DDX1 (DEAD‐box helicase 1) was overexpressed in HCC tissues and associated with poor prognosis in patients with HCC. Additionally, DDX1 expression correlated negatively with CD8+ T cell frequency. DDX1 overexpression significantly increased interferon gamma (IFN‐γ)‐mediated PD‐L1 expression in HCC cell lines. DDX1 overexpression decreased IFN‐γ and granzyme B production in CD8+ T cells and inhibited CD8+ T cell cytotoxic function in vitro and in vivo. In conclusion, DDX1 plays an essential role in developing the immune escape microenvironment, rendering it a potential predictor of ICI therapy efficacy in HCC.
Oral cancer epidemiology in relation to inter‐country disparities in human development in south and Southeast Asia
Authors: Amanat Muhammad Usman , Sriplung Hutcha , Kerdpon Duangporn 
Published: January 2024

AbstractObjectivesSouth Asia (SA) and Southeast Asia (SEA) are geographically close; however, discrepancies in oral cancer (OC) epidemiology exist between the two regions. Socioeconomic disparities may influence the OC burden. The aim of this study was to assess the epidemiology of OC and its relationship with the Inequality Adjusted Human Development Index (IHDI) and its components in SA and SEA.MethodsCancer data for this ecological study was obtained from GLOBOCAN 2020, while the IHDI was obtained from the Human Development Report 2020. Based on data availability, 14 SA and SEA countries were chosen. Poisson log‐weighted regression models were employed to examine IHDI and its components in relation to incidence and mortality. Univariate linear regression models were utilized to determine the association between the mortality‐to‐incidence ratio (MIR) and the IHDI.ResultsMortality and MIR of OC were negatively correlated with all sub‐indices of the IHDI, including education, health and income. However, incidence and mortality of OC were influenced by region and sex.ConclusionsHigher IHDI countries tended to have lower MIR. SA and males showed higher incidence and mortality. Reducing intra‐country inequalities in development may be a pragmatic approach to enhancing the OC burden and prognosis.
Risk subgroups and intervention effects among infants at high risk for peanut allergy: A model for clinical decision making
Authors: Li Yuxiang , Devonshire Ashley , Huang Bin , Andorf Sandra 
Published: January 2024

AbstractBackgroundThe Learning Early About Peanut Allergy (LEAP) trial showed that early dietary introduction of peanut reduced the risk of developing peanut allergy by age 60 months in infants at high risk for peanut allergy. In this secondary analysis of LEAP data, we aimed to determine risk subgroups within these infants and estimate their respective intervention effects of early peanut introduction.MethodsLEAP raw data were retrieved from ITNTrialShare.org. Conditional random forest was applied to participants in the peanut avoidance arm to select statistically important features for the classification and regression tree (CART) analysis to group infants based on their risk of peanut allergy at 60 months of age. Intervention effects were estimated for each derived risk subgroup using data from both arms. Our main model was generated based on baseline data when the participants were 4–11 months old. Specific IgE measurements were truncated to account for the limit of detection commonly used by laboratories in clinical practice.ResultsThe model found infants with higher predicted probability of peanut allergy at 60 months of age had a similar relative risk reduction, but a greater absolute risk reduction in peanut allergy with early introduction of peanut, than those with lower probability. The intervention effects were significant across all risk subgroups. Participants with baseline peanut sIgE ≥0.22 kU/L (n = 78) had an absolute risk reduction of 40.4% (95% CI 27.3, 51.9) whereas participants with baseline peanut sIgE<0.22 kU/L and baseline Ara h 2 sIgE <0.10 kU/L (n = 226) had an absolute risk reduction of 6.5% (95% CI 2.6, 11.0). These findings were consistent in sensitivity analyses using alternative models.ConclusionIn this study, risk subgroups were determined among infants from the LEAP trial based on the probability of developing peanut allergy and the intervention effects of early peanut introduction were estimated. This may be relevant for further risk assessment and personalized clinical decision‐making.
Ultrasound‐guided fine‐needle aspiration by cytopathologist—Lessons learned in building a successful practice
Authors: Rollins Susan D. 
Published: January 2024

Synopsis‘Ultrasound‐guided Fine Needle Aspiration by Cytopathologist ‐ Lessons Learned in Building a Successful Practice’ discusses a cytopathologist's personal experience gained over 30 years of building and managing a successful USGFNA cytology service.
A novel approach to understanding and assessing the emotional side of type 1 diabetes: The Type 1‐Diabetes Distress Assessment System
Authors: Fisher Lawrence , Polonsky William , Naranjo Diana , Strycker Lisa , Hessler Danielle 
Published: January 2024

AbstractAimsTo describe the development of a novel, conceptually sound instrument with contemporary content for assessing diabetes distress (DD) among adults with type 1 diabetes.MethodsQualitative interviews with 15 adults and 7 clinicians were used to develop Core (intensity of DD emotional burden) and primary Source (key DD contributors) items. These were administered to a national sample recruited from the TCOYD Research Registry, T1D Exchange and our previous studies. Exploratory and confirmatory factor analyses were undertaken, along with reliability and construct validity studies, and cut‐point analyses to determine elevated DD.ResultsAnalyses based on 650 respondents yielded an 8‐item Core DD scale (α = 0.95) and 10 2‐ or 3‐item DD Source Scales (α range = 0.53–0.88): Financial Worries, Interpersonal Challenges, Management Difficulties, Shame, Hypoglycemia Concerns, Healthcare Quality, Lack of Diabetes Resources, Technology Challenges, Burden to Others and Worries about Complications. Core and Source scores were significantly associated with criterion variables: Higher DD scores were significantly linked with higher HbA1C, more frequent episodes of severe hypoglycaemia, missed boluses, and poorer quality of life (p > 0.001). A ≥2.0 scale cut‐point to define elevated DD is suggested.ConclusionsThe new T1‐Diabetes Distress Assessment System demonstrated good reliability and validity, and with measures of both Core emotional burden and Sources of DD, it provides a contemporary, flexible and practical approach to assessing DD that can be used seamlessly to inform intervention for clinicians and researchers.
Analysing the effect of ivermectin on the volatile organic compounds of dung and its possible influence on attraction to dung beetles
Authors: Urrutia Miguel A. , Cortez Vieyle , Rosa‐García Rocío , García‐Prieto Urcesino , Verdú José R. 
Published: January 2024

Abstract
Dung odours are composed of a large number of different volatile organic compounds (VOCs). Dung beetles are attracted to dung by olfactory cues, and their selection depends on the odorous VOCs emitted from this resource. The possible effects of ivermectin (IVM) on the chemical composition of dung volatile emissions and how this could modify its attraction to dung beetles have been debated for years.
In this work, we analysed the possible effects of IVM on the VOCs emitted by cattle dung and the attraction of the dung beetle Ateuchetus cicatricosus Lucas, using behavioural bioassays.
The results of the study showed that the chemical analyses of the dung volatile emissions from untreated cattle, treated cattle with IVM (200 μg/kg b.w.; collected at 7 and 14 days post‐administration) and dung spiked with IVM (100 and 500 μg/kg) were not significantly different. We detected a total of 44 VOCs among the treatments. The olfactometer bioassays showed no significant difference in the rates of attraction between different treatments.
This study suggests that cattle dung does not experiment with a direct modification of the volatile compounds emitted, either via the digestive tract of cattle or by direct addition with IVM, ruling out the possible influence of any transformation product from the anthelmintic that could be present. In addition, a change in the microbiota of the digestive tract in cattle as a result of the mode of action of the drug is not supported. Further possible indirect effects are discussed.
Late transplant‐associated thrombotic microangiopathy verified in bone marrow biopsy specimens is associated with chronic GVHD and viral infections
Authors: Hill Wolfgang , Sotlar Karl , Hautmann Anke , Kolb Hans‐Jochem , Ullmann Johanna , Hausmann Andreas , Schmidt Michael , Tischer Johanna , Pham Thu‐Trang , Rank Andreas , Hoechstetter Manuela A. 
Published: January 2024

AbstractObjectivesTo describe late transplant‐associated thrombotic microangiopathy (TA‐TMA) as chronic endothelial complication in bone marrow (BM) after allogeneic hematopoietic stem cell transplantation (HSCT).MethodsBM specimens along with conventional diagnostic parameters were assessed in 14 single‐institutional patients with late TA‐TMA (more than 100 days after HCST), including 11 late with history of early TA‐TMA, 10 with early TA‐TMA (within 100 days), and 12 non TA‐TMA patients. Three non‐HSCT patients served as control. The time points of BM biopsy were +1086, +798, +396, and +363 days after HSCT, respectively.ResultsLate TA‐TMA patients showed an increase of CD34+ and von Willebrand Factor (VWF)+ microvascular endothelial cells with atypical VWF+ conglomerates forming thickened VWF+ plaque sinus in the BM compared to patients without late TA‐TMA and non‐HSCT. Severe chronic (p = .002), steroid‐refractory GVHD (p = .007) and reactivation of HHV6 (p = .002), EBV (p = .003), and adenovirus (p = .005) were pronounced in late TA‐TMA. Overall and relapse‐free survival were shorter in late TA‐TMA than in patients without late TA‐TMA (5‐year OS and RFS: 78.6% vs. 90.2%, 71.4% vs. 86.4%, respectively).ConclusionChronic allo‐immune microangiopathy in BM associated with chronic, steroid‐refractory GVHD and/or viral infections are key findings of late, high‐risk TA‐TMA, which deserves clinical attention.
Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study
Authors: Kan Junyan , Chen Qitao , Tao Qiuwei , Wu Lida , Wang Dongchen , Jiang Zihao , Du Xufeng , Gu Yue , Gu Yong 
Published: January 2024

AbstractThe association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all‐cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19 741 participants were included in the current study, 542 (2.7%) had psoriasis and 19 199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13–1.66, p = 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13–1.64, p < 0.001) and angina pectoris (OR = 1.74, 95% CI: 1.11–2.60, p = 0.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate/severe but not mild patients showed significantly higher CVD mortality (HR = 2.55, 95% CI: 1.27–5.15, p = 0.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate/severe psoriasis on CVD mortality accounted for 81.4% (65.8%–97.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Moderate‐to‐severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease‐related examinations for patients with higher severity of psoriasis in clinical settings.
IETAFusion: An illumination enhancement and target‐aware infrared and visible image fusion network for security system of smart city
Authors: Guo Shuang , Wu Kun , Jeon Seunggil , Yang Xiaomin 
Published: January 2024

AbstractIn the environmental security monitoring of smart cities, the infrared and visible image fusion method deployed on intelligent systems based on cloud and fog computing plays a vital role in providing enhanced images for target detection systems. However, the fusion quality can be significantly influenced by the illumination of the monitoring scenario in visible images. Therefore, conventional methods typically suffer a severe performance drop under the condition of insufficient illumination. To tackle this issue, we propose an illumination enhancement and target‐aware fusion method‐based on artificial intelligence, which breaks the boundaries between the task of illumination enhancement and image fusion and provide a fusion result with better visual perception in nighttime scene. Specifically, we use a light‐weight contrast enhancement module restore the brightness of the visible image. Moreover, a Swin Transformer‐based backbone network is utilized to facilitate information exchange between the source images and enhance the capabilities of target awareness. Finally, the fused images are reconstructed by the contrast‐texture retention module and reconstructor. The extensive experiments indicate that the proposed approach achieves improved performance both in human perception and quantitative analysis compared with the state‐of‐the‐art methods.
Mineral composition controls the stabilization of microbially derived carbon and nitrogen in soils: Insights from an isotope tracing model
Authors: Wang Xu , Wang Chao , Fan Xianlei , Sun Lifei , Sang Changpeng , Wang Xugao , Jiang Ping , Fang Yunting , Bai Edith 
Published: January 2024

AbstractEvidence is emerging that microbial products and residues (necromass) contribute greatly to stable soil organic matter (SOM), which calls for the necessity of separating the microbial necromass from other SOM pools in models. However, the understanding on how microbial necromass stabilizes in soil, especially the mineral protection mechanisms, is still lacking. Here, we incubated 13C‐ and 15N‐labelled microbial necromass in a series of artificial soils varying in clay minerals and metal oxides. We found the mineralization, adsorption and desorption rate constants of necromass nitrogen were higher than those of necromass carbon. The accumulation rates of necromass carbon and nitrogen in mineral‐associated SOM were positively correlated with the specific surface area of clay minerals. Our results provide direct evidence for the protection role of mineral in microbial necromass stabilization and provide a platform for simulating microbial necromass separately in SOM models.
Precarity in Burhan Qurbani's Berlin Alexanderplatz (2020)
Authors: Wolf Franziska 
Published: January 2024

AbstractWhen Burhan Qurbani's adaptation of Döblin's modernist classic Berlin Alexanderplatz premiered in 2020, criticism included the allegation that Qurbani's protagonist Francis—a Black refugee from Guinea‐Bissau stranded at the outskirts of present‐day Berlin—does not resemble the novel's released prisoner and street vendor Franz Biberkopf. This article presents a comparative investigation of Qurbani's Francis and Döblin's Biberkopf. Drawing on Judith Butler's writing on precarity, grievability, and the quest for a “good life,” I consider how both Francis and Biberkopf face increased risk of injury, occupy a liminal space in society, and cannot fulfill their intention to be morally good while also achieving upward social mobility. Their failure is a direct consequence of their politically and socioeconomically precarious condition: Biberkopf belongs to the underclass of the lumpenproletariat, whereas Francis, as an undocumented immigrant, is exposed to neoliberal hyper‐precarity.
Factors associated with the outcome of root canal treatment—A cohort study conducted in a private practice
Authors: Jurič Rok , Vidmar G. , Blagus R. , Jan Janja 
Published: January 2024

AbstractAimTo investigate the association of various pre‐, intra‐ and post‐operative factors on root canal treatment outcome.MethodologyIn this cohort study, primary or secondary root canal treatment of mature permanent teeth was performed by a single endodontist in a private practice over 13 years, and followed 1–4 years after treatment. Treatment details and clinical and radiographic data were collected. The proportion of successfully treated teeth and roots based on strict radiographic (periapical index (PAI) ≤2) and clinical criteria (absence of pain, swelling or sinus tract) was estimated. To evaluate joint associations of prognostic factors and treatment success probability, 44 pre, intra‐ and post‐operative factors were investigated using bivariate associations, and a multiple logistic regression model was fitted using Generalized Estimating Equations.Results1259 teeth (2445 roots, 3149 canals) were assessed with a recall rate of 91%. The proportion of successfully treated teeth was 79.9% [95% confidence interval 77.7–82.1]. Eleven prognostic factors were identified that significantly reduced the odds ratio (OR) for treatment success at tooth level. Six were preoperative: injury history (OR = 0.05[0.01–0.24]), root PAI (OR = 0.29[0.20–0.42], 0.21[0.13–0.34] and 0.22[0.12–0.42] for PAI = 3, 4 and 5, respectively, against PAI = 1), lesion diameter (OR = 0.30[0.21–0.43] and 0.24[0.16–0.37] for diameters of 1‐5 mm and ≥6 mm, respectively, against no lesion), tooth type (OR = 0.51[0.27–0.97] and OR = 0.45[0.24–0.83] for premolars and molars, respectively, against incisors or canines), tenderness to periapical palpation (OR = 0.64[0.43–0.94]) and two canals per root (OR = 0.67[0.54–0.83]). Four factors were intraoperative: root filling of unsatisfactory quality (OR = 0.18[0.08–0.40]) or extending beyond or shorter than 2 mm from the apex (OR = 0.44[0.26–0.75] and 0.62[0.40–0.97] respectively), resin sealer (OR = 0.58[0.39–0.87] against bioceramic sealer) and single visit treatment (OR = 0.40[0.21–0.75] against multiple visits). One factor was post‐operative: defective coronal restoration (OR = 0.35[0.21–0.56]).ConclusionThe following factors were associated with unsuccessful root canal treatment: (i) history of injury, apical periodontitis with increased severity (larger lesion, higher PAI, tenderness to periapical palpation), or complicated anatomic conditions (premolar or molar, two canals in a single root); (ii) technically suboptimal root filling (of unsatisfactory quality or not ending within 2 mm of radiographic apex) performed in a single‐visit, or use of resin sealer instead of novel bioceramic sealer; (iii) suboptimal quality coronal restoration.
Dynamically guided transantral piezoelectric endodontic microsurgery: A case report with technical considerations
Authors: Villa‐Machado Paula Andrea , Restrepo‐Restrepo Felipe Augusto , Tobón‐Arroyave Sergio Iván 
Published: January 2024

AbstractAimEndodontic microsurgery (EMS) of maxillary molars may represent a complex challenge to the clinician due to the location of the roots and the proximity of the maxillary sinus floor. This report aimed to describe the simultaneous use of a computer‐assisted dynamic navigation (C‐ADN) system and piezoelectric bony‐window osteotomy for the transantral microsurgical approach of a maxillary left first molar with adequate root canal filling and symptomatic apical periodontitis.SummaryThis case report highlights the importance of C‐ADN to carry out a minimally invasive buccal surgical access to palatal roots affected by apical periodontitis and provides a practical example to help clinicians make treatment decisions based on the available evidence. Clinical and tomographic evaluations were performed before the surgical procedure and at 24‐month follow‐up. This case was treated using a C‐ADN system fitted to a piezotome for the buccal approach of the buccal roots, maxillary sinus membrane lifting, and for transantral location, root‐end resection, cavity preparation, and filling of the palatal root. The navigation system allowed to achieve an accurate apical canal terminus location and root‐end filling of the three roots with a minimally invasive piezoelectric crypt approach. At the 24‐month follow‐up examination, the patient remains asymptomatic, with normal periapical structures, and regeneration of maxillary sinus walls. It was concluded that the combination of dynamic navigation with piezoelectric bony‐window osteotomy offers enhanced accuracy, tissue preservation, diminished risk of iatrogenic complications, and could maximize success and survival rates in transantral EMS.
Reduced C‐reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study
Authors: Garrido Mauricio , Bordagaray María José , Schweitzer Catalina , Lucero‐Mora Joaquín , Reyes Montserrat , Pellegrini Elizabeth , Hernández‐Ríos Patricia , Fernández Alejandra , Hernández Marcela 
Published: January 2024

AbstractAimTo determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT).MethodologyProspective pre‐/post‐study. Apical periodontitis (AP) individuals aged 16–40 were included (N = 29). Individuals received RCT and were followed at 1 and 6 months. Fasting blood samples were obtained. Apical lesions of endodontic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)‐α, interleukin (IL)‐6, IL‐10, IL‐1β, and soluble (s) E‐selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP ≥1 mg/L) by immunowestern blot (n = 15). Also, CRP isoforms were explored in ALEOs from AP individuals (n = 4). Data were analysed with StataV16.ResultsPeriapical index and ALEO sizes were reduced at both follow‐up visits after RCT (p < .05). Serum levels of TNF‐α, IL‐6, IL‐10, IL‐1β, and sE‐selectin did not show significant differences. CRP was borderline reduced at 1 month (p = .04); however, in AP individuals at cardiovascular risk (hsCRP ≥ 1 mg/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6 months (p < .05).ConclusionsHigh‐sensitivity CRP and mCRP are reduced after RCT in AP individuals at cardiovascular risk.