bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitale Zwillinge für Brücken mittlerer Stützweite – Pilotprojekt Brücke Schwindegg – Teil 1: Sensorik
Authors: Wimmer Johannes , Braml Thomas , Martinez Robert 
Published: November 2023

AbstractDie Brückenerhaltung stellt in den nächsten Jahren eine wesentliche Aufgabe zur Aufrechterhaltung der Infrastruktur dar. Gerade bei Brücken mit kleinen und mittleren Stützweiten im kommunalen Straßennetz steht mittlerweile in vielen Fällen nicht mehr ausreichend Personal für Bauwerksprüfung und ‐unterhalt zur Verfügung. Es ist daher zukünftig erforderlich, Konzepte für eine teilautomatisierte Brückenprüfung zu entwickeln. Stehen Informationen aus Einwirkungen und Widerständen von Bauwerken zur Verfügung, so enthalten die Messwerte wichtige Informationen zum Bauwerkszustand. Ein Konzept hierfür können Digitale Zwillinge sein. Auf Basis von Digitalen Zwillingen und den darin enthaltenen Informationen kann ein intelligentes Erhaltungsmanagement umgesetzt werden. In einem zweiteiligen Beitrag wird das Konzept für Digitale Zwillinge für Brücken mittlerer Stützweite vorgestellt. Dieser erste Teil stellt die Sensorausstattung einer einfeldrigen Spannbetonrahmenbrücke für ein Monitoring mit der Perspektive eines Digitalen Zwillings vor.
Co‐current filtrate flow in TFF perfusion processes: Decoupling transmembrane pressure from crossflow to improve product sieving
Authors: Romann Patrick , Giller Philip , Sibilia Antony , Herwig Christoph , Zydney Andrew L. , Perilleux Arnaud , Souquet Jonathan , Bielser Jean‐Marc , Villiger Thomas K. 
Published: November 2023

AbstractHollow fiber‐based membrane filtration has emerged as the dominant technology for cell retention in perfusion processes yet significant challenges in alleviating filter fouling remain unsolved. In this work, the benefits of co‐current filtrate flow applied to a tangential flow filtration (TFF) module to reduce or even completely remove Starling recirculation caused by the axial pressure drop within the module was studied by pressure characterization experiments and perfusion cell culture runs. Additionally, a novel concept to achieve alternating Starling flow within unidirectional TFF was investigated. Pressure profiles demonstrated that precise flow control can be achieved with both lab‐scale and manufacturing‐scale filters. TFF systems with co‐current flow showed up to 40% higher product sieving compared to standard TFF. The decoupling of transmembrane pressure from crossflow velocity and filter characteristics in co‐current TFF alleviates common challenges for hollow fiber‐based systems such as limited crossflow rates and relatively short filter module lengths, both of which are currently used to avoid extensive pressure drop along the filtration module. Therefore, co‐current filtrate flow in unidirectional TFF systems represents an interesting and scalable alternative to standard TFF or alternating TFF operation with additional possibilities to control Starling recirculation flow.
Mental health criminal defenses in persons with neuropsychiatric disorders
Authors: Frierson Richard L. , Joshi Kaustubh G. 
Published: November 2023

AbstractPersons with neuropsychiatric disorders present specific and unique challenges for forensic experts and defense attorneys in the criminal justice system. This article reviews two potential criminal defenses: legal insanity and the various legal standards or tests of criminal responsibility that are used in jurisdictions throughout the United States (i.e., the M’Naghten standard and the American Law Institute's Model Penal Code), and the partial legal defense of diminished capacity (lacking the mental state necessary to be found guilty of a specific intent crime). The process of evaluating criminal responsibility or diminished capacity is also presented with a specific emphasis on common issues that arise in evaluating defendants with Intellectual Developmental Disorder (Intellectual Disability), Parasomnias, Seizure Disorders, and Neurocognitive Disorders.
Efficiency of ultrafiltration/diafiltration in removing organic and elemental process equipment related leachables from biological therapeutics
Authors: Sun Bin , Hadidi Mahsa , Santiago Nuñez Jose , Song Benben , Tumambac Gilbert E. , Wong Ken , Kalinowski Gregor , Hathcock James J. 
Published: November 2023

AbstractIn the production of biological therapeutics such as monoclonal antibodies (mAbs), ultrafiltration and diafiltration (UF/DF) are widely regarded as effective downstream processing steps capable of removing process equipment related leachables (PERLs) introduced upstream of the UF/DF step. However, clearance data available in the literature are limited to species with low partition coefficients (log P) such as buffer ions, hydrophilic organic compounds, and some metal ions. Additional data for a wide range of PERLs including hydrophobic compounds and elemental impurities are needed to establish meaningful, comprehensive safety risk assessments. Herein, we report the results from studies investigating the clearance of seven different organic PERLs representing a wide range of characteristics (i.e., log P (−0.3 to 18)), and four model elements with different chemical properties spiked into a mAb formulation at 10 ppm and analyzed during clearance using gas chromatography–mass spectrometry (GC–MS), liquid chromatography‐photodiode‐array‐mass spectrometry (LC‐PDA‐MS), and inductively coupled plasma mass spectrometry (ICP‐MS). The clearance data showed ideal clearance and sieving of spiked organic PERLs with log P < 4, partial clearance of PERLs with 4 < log P < 9, and poor clearance of highly hydrophobic PERLs (log P > 9) after nine diafiltration volumes (DVs). Supplemental clearance studies on seven additional PERLs present at much lower concentration levels (0.1–1.5 ppm) in the mAb formulation upstream of UF/DF and three PERLs associated with the tangential flow filtration (TFF) equipment also demonstrated the similar correlations between log P and % clearance. For model elements, the findings suggest that UF/DF in general provides ideal clearance for elements. Evidence showed that the UF/DF process does not only help mitigate leachables risk from PERLs introduced upstream of UF/DF, but also from the TFF operation itself as all three TFF‐related PERLs were effectively cleared. Overall, the UF/DF clearance presented in this work demonstrated whereas highly hydrophobic PERLs and elements that exist as charged species, particularly transition metal ions, may not be as effectively cleared and thus warrant further risk assessment; hydrophilic and some hydrophobic PERLs (log P < 4) are indeed well‐cleared and thus present a lower overall safety risk.
Therapeutic alliance in psycho‐oncology: A systematic review
Authors: Flock Charlotte , Grapp Miriam , Oldsen Rahel , Friederich Hans‐Christoph , Bugaj Till Johannes 
Published: November 2023

AbstractObjectivesThere is evidence of a significant role for therapeutic alliance (TA) in psycho‐oncology care. This review aims to provide an overview by systematically identifying key characteristics of TA in this setting and exploring related concepts.MethodsPubMed, PsycInfo and Web of Science were systematically searched for empirical studies on adult cancer patients receiving psycho‐oncological care considering TA. Quality assessment was undertaken using the Mixed Methods Appraisal Tool. A narrative synthesis was conducted.ResultsOf the 4647 identified publications, 24 quantitative, qualitative and mixed‐methods studies were included. Characteristics of studies, interventions and samples were heterogenic. Patients consistently reported high TA scores. Favourable associations of TA with distress and well‐being and mixed results for further outcomes and compliance were detected. Associations between the patient's and therapist's characteristics yielded mixed results. Qualitative evidence pointed to a unique nature of TA in psycho‐oncology, for example, patients experiencing it in the context of other patient–provider relationships occurring in the context of the disease.ConclusionThe review displays a unique synopsis of a heterogenic, quickly developing research field. First hints towards the efficacy and particularity of TA in psycho‐oncology are delivered. Results encourage further focus on TA, both in psycho‐oncological research and in clinical practice.
Long‐term follow‐up of a young male who developed acute macular neuroretinopathy following COVID‐19 vaccination
Authors: Ikema Shunsuke , Miura Gen , Shimizu Daisuke , Baba Takayuki 
Published: November 2023

Key Clinical MessageThis report presents the clinical findings and prognosis of a healthy male patient who developed acute macular neuroretinopathy after COVID‐19 vaccination. Abnormal findings improved about 1 month after the onset and disappeared 3 months later. The subjective symptoms disappeared in 3 months, and no recurrence was observed for 1 year.
Unravelling CO2 Reduction Reaction Intermediates on High Entropy Alloy Catalysts: An Interpretable Machine Learning Approach to Establish Scaling Relations
Authors: Roy Diptendu , Charan Mandal Shyama , Das Amitabha , Pathak Biswarup 
Published: November 2023

AbstractEstablishment of a scaling relation among the reaction intermediates is highly important but very much challenging on complex surfaces, such as surfaces of high entropy alloys (HEAs). Herein, we designed an interpretable machine learning (ML) approach to establish a scaling relation among CO2 reduction reaction (CO2RR) intermediates adsorbed at the same adsorption site. Local Interpretable Model‐Agnostic Explanations (LIME), Accumulated Local Effects (ALE), and Permutation Feature Importance (PFI) are used for the global and local interpretation of the utilized black box models. These methods were successfully applied through an iterative way and validated on CuCoNiZnMg and CuCoNiZnSnbased HEAs data. Finally, we successfully predicted adsorption energies of *H2CO (MAE: 0.24 eV) and *H3CO (MAE: 0.23 eV) by using the *HCO training data. Similarly, adsorption energy of *O (MAE: 0.32 eV) is also predicted from *H training data. We believe that our proposed method can shift the paradigm of state‐of‐the‐art ML in catalysis towards better interpretability.
Preparation and performance study of functional polymer with self demulsifying
Authors: Chen Bin , Zhao Lin , Zhang Ning , Wang Chengsheng , Wang Xiujun , Su Yanhui , Wu Xiaoyan , Liu Guanjun , Yi Fei 
Published: November 2023

AbstractIn polymer flooding, the residual polymer in the produced fluid can increase the stability of crude oil emulsion, thereby negatively affecting the demulsification process. Therefore, a polymer that has no effect on the stability of crude oil emulsion is required. Herein, a polymerizable monomer with a demulsification function (MD) was synthesized and then copolymerized with acrylamide, acrylic acid, and 2‐acrylamide‐2‐methylpropane sulfonic acid to prepare a novel copolymer (self‐demulsifying polymer, PDM). The dissolution time, solution viscosity, shear resistance, static adsorption on quartz sand, and the effect on the crude oil emulsion stability of PDM were compared with those of regular polyacrylamide (PAM). Experimental results showed that owing to the steric hindrance effect of MD, the molecular weight of PDM was lower than that of PAM. Both polymers exhibited satisfactory solubility, solution viscosity, shear resistance, and static adsorption, which can meet the requirements of polymer for use in oil displacement. However, in contrast to PAM, PDM had no negative effect on the crude oil emulsion stability. This study provides a new solution to the problem of increased crude oil emulsion stability in polymer flooding.
Benefit of primary and secondary prophylactic implantable cardioverter defibrillator in elderly patients
Authors: Lewenhardt Marie , Kreimer Fabienne , Aweimer Assem , Pflaumbaum Andreas , Mügge Andreas , Gotzmann Michael 
Published: November 2023

AbstractBackgroundThe benefit of implantable cardioverter‐defibrillator (ICD) in elderly patients has been questioned. In the present study, we aimed to analyse the outcome of patients of different age groups with ICD implantation.MethodsWe included all patients who received an ICD in our hospital from 2011 to 2020. Primary endpoints were (1) death from any cause and (2) appropriate ICD therapy (antitachycardia pacing/shock). A “benefit of ICD implantation” was defined as appropriate ICD therapy before death from any cause/or survival. “No benefit of ICD implantation” was defined as death from any cause without prior appropriate ICD therapy.ResultsA total of 422 patients received an ICD (primary prophylaxis n = 323, secondary prophylaxis n = 99). At the time of implantation, 35 patients (8%) were >80 years and 106 patients were >75 years (25%). During the study period of 4.2 ± 3 years, benefit of ICD occurred in 89 patients (21%) and no benefit in 84 patients (20%). In primary prevention, the proportion of patients who had a benefit from ICD implantation decreased with increasing age, and there were no patients who benefited from ICD therapy in the group of patients >80 years. In secondary prophylaxis, the proportion of patients with a benefit from ICD implantation ranged from 20% to 30% in all age groups.ConclusionOur study suggests that the indication of primary prophylactic ICD in elderly and very old patients should be critically assessed. On the other hand, no patient should be denied secondary prophylactic ICD implantation because of age.
Walking energetics and white matter hyperintensities in mid‐to‐late adulthood
Authors: Dougherty Ryan J. , Wanigatunga Amal A. , An Yang , Tian Qu , Simonsick Eleanor M. , Albert Marilyn S. , Resnick Susan M. , Schrack Jennifer A. 
Published: November 2023

AbstractINTRODUCTIONWhite matter hyperintensities (WMHs) increase with age and contribute to cognitive and motor function decline. Energy costs for mobility worsen with age, as the energetic cost of walking increases and energetic capacity declines. We examined the cross‐sectional associations of multiple measures of walking energetics with WMHs in mid‐ to late‐aged adults.METHODSA total of 601 cognitively unimpaired adults (mean age 66.9 ± 15.3 years, 54% women) underwent brain magnetic resonance imaging scans and completed standardized slow‐ and peak‐paced walking assessments with metabolic measurement (V̇O2). T1‐weighted scans and fluid‐attenuated inversion recovery images were used to quantify WMHs. Separate multivariable linear regression models examined associations adjusted for covariates.RESULTSLower slow‐paced V̇O2 (B = 0.07; P = 0.030), higher peak‐paced V̇O2 (B = –0.10; P = 0.007), and lower cost‐to‐capacity ratio (B = .12; P < 0.0001) were all associated with lower WMH volumes.DISCUSSIONThe cost‐to‐capacity ratio, which describes the percentage of capacity required for ambulation, was the walking energetic measure most strongly associated with WMHs.
Electroactive Prussian Blue Analogues/TiO2 Nanocomposites Obtained through SILAR Assembly in Mesoporous Nanoarchitectures
Authors: Vensaus Priscila , Caraballo Rolando M. , Tritto Emiliano , Fernández Cynthia C. , Angelomé Paula C. , Fuertes M. Cecilia , Williams Federico J. , Soler‐Illia Galo J. A. A. , Baraldo Luis M. 
Published: November 2023

AbstractThe preparation of nanomaterials for energy applications such as intercalation batteries and materials that can act as substrates for water oxidation is a subject of major interest nowadays. In this work, we report the deposition of Prussian blue (PB) and its cobalt analogue (CoPBA) on mesoporous titania thin films (MTTF) using the successive ionic layer adsorption reaction (SILAR) technique under soft conditions. A bifunctional ligand, 1,10‐phenanthroline‐5,6‐dione (pd), was used to functionalize the titania surface and promote the growth of PB and CoPBA. The resulting PB@MTTF and CoPBA@MTTF nanocomposites were characterized using several techniques and it was determined that PB and CoPBA grow in a controlled and sequential manner, maintaining the mesoporous architecture. Both PB@MTTF and CoPBA@MTTF demonstrated very good electroactive properties, while CoPBA@MTTF exhibited water oxidation capabilities. The flexibility of this PBA@MTTF platform allows the incorporation of any labile transition metal ion or fragment into the structure of the coordination polymer embedded into a mesoporous matrix, opening the door for (photo)electrochemical devices and catalysts.
If only they knew! A non‐inferiority randomized controlled trial comparing deceptive and open‐label placebo in healthy individuals
Authors: Druart L. , Graham Longsworth S. E. , Terrisse H. , Locher C. , Blease C. , Rolland C. , Pinsault N. 
Published: November 2023

AbstractBackgroundPlacebo use is widespread in clinical practice. However, they are most often administered deceptively rather than openly. It is often suggested that open‐label placebos (OLP) are less effective than deceptive placebos (DP). This study aimed to compare the use of DP and OLP treatments to reduce pain in healthy volunteers.MethodsWe conducted a non‐inferiority, parallel, randomized, controlled trial, which also included a nested cross‐over no‐treatment condition. This study was conducted at a university clinic in France.ResultsWe included 60 subjects and the main result shows that the OLP was not inferior to the DP by a margin of 10 mm. The mean difference between both groups regarding intensity of pain was 0.7 mm with a 95% compatibility interval (95% CI) of ]−∞; 5.4], and 97.5% CI of ]−∞; 6.3]. Secondary outcomes require cautious interpretation of the effect of placebo versus no treatment due to a time–treatment interaction.ConclusionThe study indicates that OLP may perform just as well as DP and could provide support for the use of OLP as an ethical alternative to DP when they are to be used in a clinical setting. If only patients knew about the placebo nature of some treatments they are receiving, unnecessary lies could be avoided while maintaining similar placebo effects.SignificanceThis study is the first to show non‐inferiority of placebos administered honestly, also called OLP, compared to DP in reducing pain. This suggests that OLP could be as effective as their deceptive counterparts while having the ethical advantage of not being required to lie. If deception is not a necessary condition for efficacy, OLP should be preferred over DP.
Improved Synthesis of Chiral 1,4,7‐Triazacyclononane Derivatives and Their Application in Ni‐Catalyzed Csp3−Csp3 Kumada Cross‐Coupling
Authors: Hu Chi‐Herng , Byeong Chae Ju , Mirica Liviu M. 
Published: November 2023

AbstractHerein, we report four new chiral 1,4,7‐triazacyclononane (TACN) derivatives and their corresponding nickel(II) chloride complexes. All TACN ligands are bearing one chiral N‐substituent and two alkyl (methyl or tert‐butyl) N‐substituents, and we have developed a new synthetic method for the dimethyl‐substituted TACN derivative, in order to prevent the rotational isomers that hinder the cyclization reaction. The nickel complexes change their coordination geometry significantly depending on the steric bulk of the N‐alkyl substituents, from a dinuclear tris(μ‐chloro)dinickel complex to mononuclear Ni‐dichloride and Ni‐chloride complexes. These complexes were then employed in the alkyl‐alkyl Kumada cross‐coupling reaction and revealed that the more sterically hindered ligands produced more homocoupled product rather than the cross‐coupled product, while the mononuclear Ni‐dichloride complex exhibited significantly lower catalytic activity. These chiral complexes were also employed in enantioconvergent cross‐coupling reactions as well, to afford significant enantioenrichment. Overall, the least sterically hindered Ni complex yields the best yields in the alkyl‐alkyl Kumada cross‐coupling reaction among the four complexes investigated, as well as the highest enantioselectivity.
Examining the female‐talker default in experimental language acquisition research
Authors: Holtz Annie , Papineau Brandon T. 
Published: November 2023

AbstractExperimental research on language acquisition and development regularly employs auditory stimuli as part of the methodology. This project analyses the apparent standard practice of using female speakers to produce these experimental materials and the potential consequences of such a practice. To situate the discussion in the current scientific landscape we present a systematic review of published literature between 2017 and 2022 to establish how prevalent this practice is. The review finds a strong bias in favour of female‐spoken stimuli across publications in a curated set of nine journals. We discuss this result in light of gender‐based workplace inequality, changing caregiver expectations and the reliability of infants' assumed female voice preference. This project seeks to encourage researchers to consider how diversifying the stimuli used in these types of studies would lead to both a more inclusive and representative research landscape, as well as ensure that our research results are generalizable.
Sleep disorder identification using wavelet scattering on ECG signals
Authors: Sharma Manish , Lodhi Harsh , Yadav Rishita , Acharya U. Rajendra 
Published: November 2023

AbstractSleep affects the functioning of all biological processes in the human body. Sleep disorders disrupt the well‐being of an individual and can potentially lead to other health complications. It affects a large part of the population, and their timely and efficient detection is crucial for improving the quality of health. Sleep disorders are generally analyzed using polysomnogram (PSG) signals, which must be captured in sophisticated laboratory settings. However, electrocardiogram (ECG) signals provide information about the electrical activity of the heart, which is strongly linked with disturbances in sleep and can be used as an indicator of disordered sleep. Along with that, the recording of ECG signals is much easier than other signals and can be done remotely without causing any significant disturbance to the subject. This brings practicality to the systems that are already being employed for sleep disorder detection. In this paper, we present a method for identifying types of sleep disorders using ECG signals. The objective of this paper is to investigate the use of ECG signals for the automated identification of insomnia, narcolepsy, periodic leg movement (PLM), rapid eye movement (REM) behavior disorder (RBD), and nocturnal frontal lobe epilepsy (NFLE) against healthy subjects. We aim to develop a machine learning‐based algorithm that automatically classifies ECG signals into these sleep disorder categories. The cyclic alternating pattern (CAP) sleep database was used in this study, which contains PSG recordings from individuals with and without sleep disorders, including insomnia, narcolepsy, PLM, RBD, and NFLE. A wavelet scattering network has been used to extract features from the ECG signals. Various classifiers were tested, and the ensemble bag of trees classifier provided the optimum performance. An overall accuracy of 98% was obtained for the identification of sleep disorders, along with a classification accuracy of 99.37%, 99.45%, 99.23%, 99.4%, and 99.65% for insomnia, narcolepsy, NFLE, PLM, and RBD, respectively, for binary classification against healthy subject data. Our results show that wavelet scattering network and ensemble of bagged tree (EbagT) classification can accurately identify various sleep disorders. They provided evidence that ECG signals can be used to identify and diagnose sleep disorders, which could lead to the development of accurate detection of these sleep disorders. Also, our study demonstrated the effectiveness of the proposed algorithm in identifying multiple sleep disorders, which could lead to more efficient and cost‐effective diagnosis and treatment of sleep disorders.