bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reclassification and Multilingual Learners' Science Achievement
Authors: Pacheco Mark B. , Curran F. Chris , Boza Lelydeyvis , Deig Amber W. , Harris Katharine T. , Tan Tiffany S. 
Published: November 2023

AbstractThis study contributes to a growing body of scholarship at the intersection of bilingual education and education policy and examines reclassification, or the transition out of formal English language services in schools, as one potential lever in accelerating or decelerating multilingual learners’ science learning. More specifically, it traces multilingual learners’ science academic achievement vis‐à‐vis science test scores over a six‐year period using the nationally‐representative Early Childhood Longitudinal Study of 2010–11 (ECLS‐K:2011) data set. We use regression analyses with panel data to explore the relationship of reclassification with MLs’ science achievement at a national scale, and then, how variation in contextual factors (including family, school, and individual characteristics) shapes this relationship. Results show that, after controlling for covariates and prior test scores, reclassification is not significantly associated with differential science test scores when compared to students that retain their EL status. Results further show that reclassification is associated with higher science achievement for MLs who were previously in a dual‐language program but lower scores for those with higher prior achievement. We conclude with implications for the reclassification process, as well as directions for future research on reclassification, multilingual learners, and academic achievement.
Perinatal exposure to bisphenol A impairs cognitive function via the gamma‐aminobutyric acid signaling pathway in male rat offspring
Authors: Guo Yi , Kang Yuxin , Bai Wenjie , Liu Qiling , Zhang Rongqiang , Wang Yuxin , Wang Chong 
Published: November 2023

AbstractBisphenol A (BPA) is a common synthetic endocrine disruptor that can be utilized in the fabrication of materials such as polycarbonates and epoxy resins. Numerous studies have linked BPA to learning and memory problems, although the precise mechanism remains unknown. Gamma‐aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the vertebrate central nervous system, and it is intimately related to learning and memory. This study aims to evaluate whether altered cognitive behavior involves the GABA signaling pathway in male offspring of rats exposed to BPA during the prenatal and early postnatal periods. Pregnant rats were orally given BPA (0, 0.04, 0.4, and 4 mg/kg body weight (BW)/day) from the first day of pregnancy to the 21st day of breastfeeding. Three‐week‐old male rat offspring were selected for an open‐field experiment and a new object recognition experiment to evaluate the effect of BPA exposure on cognitive behavior. Furthermore, the role of GABA signaling markers in the cognition affected by BPA was investigated at the molecular level using western blotting and real‐time polymerase chain reaction (RT‐PCR). The research demonstrated that BPA exposure impacted the behavior and memory of male rat offspring and elevated the expression of glutamic acid decarboxylase 67 (GAD67), GABA type A receptors subunit (GABAARα1), and GABA vesicle transporter (VGAT) in the hippocampus while decreasing the expression levels of GABA transaminase (GABA‐T) and GABA transporter 1 (GAT‐1). These findings indicate that the alteration in the expression of GABA signaling molecules may be one of the molecular mechanisms by which perinatal exposure to BPA leads to decreased learning and memory in male rat offspring.
Simplified quantum chemistry methods to evaluate non‐linear optical properties of large systems
Authors: Löffelsender Sarah , Beaujean Pierre , de Wergifosse Marc 
Published: November 2023

AbstractThis review presents the theoretical background concerning simplified quantum chemistry (sQC) methods to compute non‐linear optical (NLO) properties and their applications to large systems. To evaluate any NLO responses such as hyperpolarizabilities or two‐photon absorption (2PA), one should evidently perform first a ground state calculation and compute its response. Because of this, methods used to compute ground states of large systems are outlined, especially the xTB (extended tight‐binding) scheme. An overview on approaches to compute excited state and response properties is given, emphasizing the simplified time‐dependent density functional theory (sTD‐DFT). The formalism of the eXact integral sTD‐DFT (XsTD‐DFT) method is also introduced. For the first hyperpolarizability, 2PA, excited state absorption, and second hyperpolarizability, a brief historical review is given on early‐stage semi‐empirical method applications to systems that were considered large at the time. Then, we showcase recent applications with sQC methods, especially the sTD‐DFT scheme to large challenging systems such as fluorescent proteins or fluorescent organic nanoparticles as well as dynamic structural effects on flexible tryptophan‐rich peptides and gramicidin A. Thanks to the sTD‐DFT‐xTB scheme, all‐atom quantum chemistry methodologies are now possible for the computation of the first hyperpolarizability and 2PA of systems up to 5000 atoms. This review concludes by summing‐up current and future method developments in the sQC framework as well as forthcoming applications on large systems.This article is categorized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Structure and Mechanism > Molecular Structures
Electronic Structure Theory > Density Functional Theory
Electronic Structure Theory > Semiempirical Electronic Structure Methods
Widerlegung des Mythos vom „Abszesswetter“, welches das Auftreten von Peritonsillitiden und Peritonsillarabszessen begünstigt
Authors: von Meyer Franziska , Storck Katharina 
Published: November 2023

Zusammenfassung
Hintergrund
Der Peritonsillarabszess (PTA) wird häufig als Komplikation der akuten Tonsillitis gesehen und ist definiert als Eiterverhalt zwischen der Tonsillenkapsel und dem peritonsillären Gewebe. Die Ätiologie und Pathogenese sind bisher noch nicht vollständig geklärt. Ein Zusammenhang zwischen bestimmten Wetterbedingungen und Temperaturschwankungen und dem Auftreten von Abszessen im Kopf-Hals-Bereich wird seit Jahren diskutiert. Hierbei ist die Frage, ob höhergradige Temperaturschwankungen prädisponierend sind für die Ausbildung von Abszessen.

Material und Methodik
Es erfolgte eine retrospektive Auswertung aller Patienten, die in einem Zeitraum von 10 Jahren (2012–2021) in der Klinik und Poliklinik für Hals, Nasen‑, Ohrenheilkunde des Klinikums rechts der Isar der Technischen Universität München mit einer Peritonsillitis oder einem PTA stationär behandelt wurden. Jeder Patient wurde einzeln mit den täglichen Temperaturdaten des statistischen Wetteramts für die Stadt München korreliert.

Ergebnisse
Insgesamt konnten 1450 Patienten in die Studie eingeschlossen werden. Von den 1450 Patienten hatten 270 Patienten (18,62 %) eine Peritonsillitis, 1180 Patienten (81,38 %) einen PTA. Eine Korrelation zwischen dem Auftreten von Peritonsillitiden oder PTA und größeren Temperaturschwankungen konnte in diesem großen Patientenkollektiv ausgeschlossen werden. Auch zeigte sich über das ganze Jahr eine ähnliche Häufigkeit von Peritonsillitiden und PTA.

Schlussfolgerung
Peritonsillitiden oder Peritonsillarabszesse entwickeln sich nach Datenlage der vorliegenden Studie wetterunabhängig.
Structure and Ecological Function of Fungal Endophytes from Stems of Different Mulberry Cultivars
Authors: Peng Fangfang , Li Xunlan , Wei Zhaoxin , Luo Youjin , Wang Wu , Han Guohui 
Published: November 2023

AbstractTo explore the microbial community structure and ecological function of mulberry and their potential relationship with the resistance of mulberry, the community structure and function of endophytic fungi in 18 mulberry cultivars were analyzed and predicted by using high-throughput sequencing technology and the FUNGuild database. A total of 352 operational taxonomic units of fungi were observed at a 97% similarity level, representing six phyla of fungi, Fungi_unclassified, Ascomycota, Basidiomycota, Zygomycota, Rozellomycota, and Chytridiomycota. Fungi_unclassified was dominant, and Ascomycota was relatively dominant in all cultivars. At the genus level, Ascomycota_unclassified was dominant, and Ampelomyces was relatively dominant, with a richness in TAIWANCHANGGUOSANG 16.47–8975.69 times that in the other cultivars. Classified Ascomycota_unclassified was 4.75–296.65 times more common in NANYUANSIJI than in the other cultivars. Based on the FUNGuild analysis method, we successfully annotated six nutrient types, namely, pathotroph, pathotroph–saprotroph, pathotroph–saprotroph–symbiotroph, saprotroph, saprotroph–symbiotroph, and symbiotroph, among which saprophytic–symbiotic accounted for the largest proportion and was absolutely dominant in TWC. This research suggests that community composition differs among cultivars and that the diversity and richness of endophytic fungi in resistant cultivars are higher than those in susceptible cultivars. The ecological functions of cultivars with different resistances are quite different.
Ethiodized oil as an imaging biomarker after conventional transarterial chemoembolization
Authors: Mendiratta-Lala Mishal , Aslam Anum , Bai Harrison X. , Chapiro Julius , De Baere Thiery , Miyayama Shiro , Chernyak Victoria , Matsui Osamu , Vilgrain Valerie , Fidelman Nicholas 
Published: November 2023

Abstract
Conventional transarterial chemoembolization (cTACE) utilizing ethiodized oil as a chemotherapy carrier has become a standard treatment for intermediate-stage hepatocellular carcinoma (HCC) and has been adopted as a bridging and downstaging therapy for liver transplantation. Water-in-oil emulsion made up of ethiodized oil and chemotherapy solution is retained in tumor vasculature resulting in high tissue drug concentration and low systemic chemotherapy doses. The density and distribution pattern of ethiodized oil within the tumor on post-treatment imaging are predictive of the extent of tumor necrosis and duration of response to treatment. This review describes the multiple roles of ethiodized oil, particularly in its role as a biomarker of tumor response to cTACE.

Clinical relevance
With the increasing complexity of locoregional therapy options, including the use of combination therapies, treatment response assessment has become challenging; Ethiodized oil deposition patterns can serve as an imaging biomarker for the prediction of treatment response, and perhaps predict post-treatment prognosis.

Key Points
• Treatment response assessment after locoregional therapy to hepatocellular carcinoma is fraught with multiple challenges given the varied post-treatment imaging appearance.
• Ethiodized oil is unique in that its’ radiopacity can serve as an imaging biomarker to help predict treatment response.
• The pattern of deposition of ethiodozed oil has served as a mechanism to detect portions of tumor that are undertreated and can serve as an adjunct to enhancement in order to improve management in patients treated with intraarterial embolization with ethiodized oil.
Modified balloons to prepare severely calcified coronary lesions before stent implantation: a systematic review and meta-analysis of randomized trials
Authors: Scalamogna Maria , Kuna Constantin , Voll Felix , Aytekin Alp , Lahu Shqipdona , Kessler Thorsten , Kufner Sebastian , Rheude Tobias , Sager Hendrik B. , Xhepa Erion , Wiebe Jens , Joner Michael , Ndrepepa Gjin , Kastrati Adnan , Cassese Salvatore 
Published: November 2023

Abstract
Background
The performance of modified balloons (namely cutting or scoring balloons) to prepare severely calcified lesions in patients undergoing percutaneous coronary intervention (PCI) remains controversial. We investigated the clinical and imaging outcomes of patients undergoing PCI assigned to modified balloon therapy to prepare severely calcified coronary lesions before stent implantation.

Methods
In this meta-analysis, we aggregated the study-level data from trials enrolling invasively treated patients who were randomly assigned to modified balloon or control therapy to prepare severely calcified lesions before stenting. The primary outcome was major adverse cardiac events (MACE), including death, myocardial infarction (MI), and repeat revascularization. The secondary outcomes included the individual components of the primary outcome, coronary perforation and final minimal stent area (MSA) as measured by intracoronary imaging.

Results
A total of 648 participants in six trials were allocated to modified balloon therapy (n = 335) or control therapy (semi-compliant, non-compliant, or super high-pressure balloon, n = 313). The median follow-up was 11 months. Overall, MACE occurred in 8.96% of patients assigned to a modified balloon and 12.78% of patients assigned to control therapy [risk ratio = 0.70, 95% confidence interval (CI) 0.35–1.39; P = 0.24]. There was a significant treatment effect-by-modified balloon type interaction for the outcome MACE in patients assigned to cutting balloon compared with control therapy [RR = 0.40 (0.28–0.56), P for interaction (Pint) < 0.001]. Patients treated with a modified balloon compared with control therapy showed neither a significant difference for the other clinical outcomes nor for final MSA [standardized mean difference = 0.67 (− 0.71, 2.06); P = 0.26].

Conclusions
In patients treated with PCI for severely calcific coronary artery disease a strategy of lesion preparation with a modified balloon before stenting does not improve clinical or imaging outcomes compared with control therapy. The different performance of cutting and scoring balloons warrants further investigation.

Graphical Abstract
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Authors: Kutschka Ilona , Bertero Edoardo , Wasmus Christina , Xiao Ke , Yang Lifeng , Chen Xinyu , Oshima Yasuhiro , Fischer Marcus , Erk Manuela , Arslan Berkan , Alhasan Lin , Grosser Daria , Ermer Katharina J. , Nickel Alexander , Kohlhaas Michael , Eberl Hanna , Rebs Sabine , Streckfuss-Bömeke Katrin , Schmitz Werner , Rehling Peter , Thum Thomas , Higuchi Takahiro , Rabinowitz Joshua , Maack Christoph , Dudek Jan 
Published: November 2023

AbstractBarth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), required for the synthesis of the phospholipid cardiolipin. BTHS is characterized by heart failure, increased propensity for arrhythmias and a blunted inotropic reserve. Defects in Ca2+-induced Krebs cycle activation contribute to these functional defects, but despite oxidation of pyridine nucleotides, no oxidative stress developed in the heart. Here, we investigated how retrograde signaling pathways orchestrate metabolic rewiring to compensate for mitochondrial defects. In mice with an inducible knockdown (KD) of TAFAZZIN, and in induced pluripotent stem cell-derived cardiac myocytes, mitochondrial uptake and oxidation of fatty acids was strongly decreased, while glucose uptake was increased. Unbiased transcriptomic analyses revealed that the activation of the eIF2α/ATF4 axis of the integrated stress response upregulates one-carbon metabolism, which diverts glycolytic intermediates towards the biosynthesis of serine and fuels the biosynthesis of glutathione. In addition, strong upregulation of the glutamate/cystine antiporter xCT increases cardiac cystine import required for glutathione synthesis. Increased glutamate uptake facilitates anaplerotic replenishment of the Krebs cycle, sustaining energy production and antioxidative pathways. These data indicate that ATF4-driven rewiring of metabolism compensates for defects in mitochondrial uptake of fatty acids to sustain energy production and antioxidation.
Serum apelin-12 and obesity-related markers in Egyptian children with Down syndrome
Authors: Yahia Sohier , Salem Nanees A. , El-Hawary Amany , Salem Mohamed , El-Farahaty Reham M. , EL-gilany Abd El-Hady , Shoaib Rasha M. S. , Noureldin Mohamed Ahmed 
Published: November 2023

AbstractChildren with Down syndrome (DS) exhibit higher overweight/obesity rates than their typically developing peers. Apelin-12 is a bioactive adipokine that exerts vital roles in obesity-related cardiometabolic comorbidities. To date, apelin-12 has not been investigated in obese-DS. This study aimed to explore the possible association between serum apelin-12 and obesity-related markers and to evaluate the efficiency of apelin-12 in the prediction of metabolic syndrome (MetS) in obese-DS compared to BMI Z-score matched obese-control. The cross-sectional study included 150 prepubertal children classified into three groups; obese-DS (n = 50), obese-control (n = 50), and normal-weight-control (n = 50). Anthropometric parameters, body adiposity, fasting serum levels of blood glucose (FBG), insulin, lipid profile, and apelin-12 were evaluated. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from FBG and insulin. MetS was defined using Adult Treatment Panel III criteria modified for the pediatric age group. ROC curves were analyzed to evaluate the efficiency of apelin-12 in predicting MetS in obesity groups. Obese-DS exhibited higher body adiposity with marked central fat distribution, atherogenic lipid profile, and higher HOMA-IR compared to obese-control. Apelin-12 was significantly higher in obese-DS and obese-DS with MetS compared to obese-control and obese-control with MetS respectively (p < 0.001). The increase in apelin-12 with higher obesity grades was pronounced in obese-DS. Apelin-12 strongly correlated with body adiposity, several MetS risk factors, and HOMA-IR in obese-DS. Significantly higher AUC for apelin-12 in the diagnosis of MetS among obese-DS than obese-control (AUC = 0.948 vs. AUC = 0.807; p = 0.04).Conclusions: The current study supports the crucial role of apelin-12 in obesity-related clinical and biochemical markers and in MetS in obese-DS and obese-control. Serum apelin-12 is a potential diagnostic biomarker for MetS with greater performance in obese-DS than obese-control raising its potential for clinical and therapeutic applications.

What is Known:• Obese-DS children displayed excess body adiposity, Pronounced central fat distribution, atherogenic lipid profile, higher HOMA-IR, and higher prevalence of MetS than obese-control.

What is New:• Higher serum apelin-12 was observed in obese-DS and obese-DS with MetS than obese-control and obese-control with MetS respectively. The increase in apelin-12 level with increasing obesity grades was more pronounced in obese-DS.• Apelin-12 strongly correlated with obesity-related markers and MetS components in obese-DS. Apelin-12 performed better as a diagnostic biomarker for MetS in obese-DS than obese-control.
Comparison of different modern irrigation system adopters through socio-economic, innovation characteristics and social capital values
Authors: Yazdanpanah Masoud , Zobeidi Tahereh , Mirzaei Abbas , Löhr Katharina , Warner Laura A. , Lamm Alexa , Rouzaneh Davoud , Sieber Stefan 
Published: November 2023

AbstractDiffusion of modern irrigation systems is one of the most important objectives of Iranian water policies targeting the sustainable use of water resources to resolve the water crisis. Despite considerable policy support, high subsidization, and a range of benefits, farmers have only minimally adopted modern irrigation systems in most parts of Iran. Therefore, the water crisis persists in almost all parts of the country. Thus, decision makers must recognize why diffusion of these systems has not been successful among farmers despite strong financial and political support. The aim of the current study was to investigate differences between adoption groups of modern irrigation systems and more critically whether the aspects affecting approval were altered by ongoing diffusion prejudiced by policy support. In other words, we explored the postponement of adoption among the early and the later adopters of modern irrigation systems and aimed to identify reasons behind different adoption behaviors. To achieve these aims, we developed a research framework of adoption that integrates multiple theories. In addition to the already established measures (human and physical capital), the current study integrated social capital and technology characteristics. A cross-sectional survey was carried out in Behbahan district in Khuzestan province southwest Iran. A total of 274 farmers were interviewed, of which 100 farmers had not and 174 farmers had adopted modern irrigation systems. A multinomial logit model was applied by using STATA14 to identify the most effective factors for farmers’ adoption decisions. We distinguished four groups; three consisted of adopters (early, middle, and late adopters) and a fourth group of non-adopters who did not accept modern irrigation technologies. The study found that farmers’ delayed adoption of drip irrigation technologies was due to the complexity of the application process and the availability of family and work social capital. Additionally, the study suggested that improved trust in institutions could increase the likelihood of earlier adoption of these technologies. The results also revealed divergent perspectives among pioneer (early adopters), follower (middle adopter), and laggard (late adopter) farmers regarding the adoption of drip irrigation technologies.
Molecular characterization and biofilm formation ability of Enterococcus faecium and Enterococcus faecalis bloodstream isolates from a Chinese tertiary hospital in Beijing
Authors: Yang Jing-xian , Liu Cun-wei , Wu Fu-wei , Zhu Ling , Liang Guo-wei 
Published: November 2023

AbstractTo investigate the molecular characteristics and biofilm-forming ability of 116 Enterococcus faecium (Efm) and 72 Enterococcus faecalis (Efs) isolates obtained from patients with bloodstream infections (BSI) at a Chinese hospital between July 2011 and March 2018. The presence of glycopeptide resistance genes and five virulence genes (esp, gelE, asa1, hyl, and cylA) was screened using two multiplex PCR. MLST was used to assess the clonality. Crystal violet staining was used to detect biofilms. Vancomycin resistance was detected in 30.1% of Efm and 2.8% of Efs isolates, respectively. All VRE strains carried the vanA gene. The esp, gelE, asa1, and cylA genes in 72 Efs strains were detected at 62.5%, 84.7%, 84.7%, and 69.4%, respectively. Among the 116 Efm isolates, 74.1% and 25.8% carried esp and hyl, respectively. The esp gene was significantly associated with vancomycin-resistant Efm (VREfm) compared to vancomycin-susceptible Efm (VSEfm). In total, 91.7% of Efs and 20.0% of Efm produced biofilms. Twenty-six STs were identified among the 72 Efs isolates, with ST4 (29.2%) being the predominant. In total, 116 Efm strains were grouped into 26 STs, with ST78 (46.6%) being the predominant. Both VREfm (41.7%) and VSEfm (48.8%) were dominant in ST78. There is no clear evidence suggesting that some STs are associated with vancomycin resistance or biofilm formation. Both Efm and Efs BSI isolates showed a polyclonal pattern with a dominant clone and many unique types, implying the coexistence of clonal dissemination and an influx of new clones. The horizontal transmission of resistance genes may play a more important role in VREfm prevalence than clonal expansion.