bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to nickel chloride induces epigenetic modification on detoxification enzyme glutathione S‐transferase M2
Authors: Kang Yu‐Ting , Yang Wan‐Jung , Huang Hsu Chih , Tang Sheau‐Chung , Ko Jiunn‐Liang 
Published: December 2023

AbstractNickel (Ni) is a human carcinogen with genotoxic and epigenotoxic effects. Environmental and occupational exposure to Ni increases the risk of cancer and chronic inflammatory diseases. Our previous findings indicate that Ni alters gene expression through epigenetic regulation, specifically impacting E‐cadherin and angiopoietin‐like 4 (ANGPTL4), involved in epithelial‐mesenchymal transition and migration. GST‐M2, a member of the glutathione S‐transferase (GST) enzyme family, plays a crucial role in cellular defense against oxidative damage and has been increasingly associated with cancer. GST‐M2 overexpression inhibits lung cancer invasion and metastasis in vitro and in vivo. Hypermethylation of its promoter in cancer cells reduces gene expression, correlating with poor prognosis in non‐small‐cell lung cancer patients. The impact of Ni on GST‐M2 remains unclear. We will investigate whether nickel exerts regulatory effects on GST‐M2 through epigenetic modifications. Additionally, metformin, an antidiabetic drug, is being studied as a chemopreventive agent against nickel‐induced damage. Our findings indicate that nickel chloride (NiCl2) exposure, both short‐term and long‐term, represses GST‐M2 expression. However, the expression can be restored by demethylation agent 5‐aza‐2′‐deoxycytidine and metformin. NiCl2 promotes hypermethylation of the GST‐M2 promoter, as confirmed by methylation‐specific PCR and bisulfite sequencing. Additionally, NiCl2 also influences histone acetylation, and metformin counteracts the suppressive effect of NiCl2 on histone H3 expression. Metformin reestablishes the binding of specificity protein 1 to the GST‐M2 promoter, which is otherwise disrupted by NiCl2. These findings elucidate the mechanism by which Ni reduces GST‐M2 expression and transcriptional activity, potentially contributing to Ni‐induced lung carcinogenesis.
Effect of cannula insertion site during fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia on preterm prelabor rupture of membranes
Authors: Cordier A.‐G. , Badr D. A. , Basurto D. , Russo F. , Deprest J. , Orain E. , Eixarch E. , Otano J. , Gratacos E. , Moraes De Luna Freire Vargas A. , Peralta C. F. A. , Jani J. C. , Benachi A. 
Published: December 2023

ABSTRACTObjectiveTo assess whether the cannula insertion site on the maternal abdomen during fetal endoscopic tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH) was associated with preterm prelabor rupture of membranes (PPROM) before balloon removal.MethodsThis was a multicenter retrospective study of consecutive pregnancies with isolated left‐ or right‐sided CDH that underwent FETO in four centers between January 2009 and January 2021. The site for balloon insertion was categorized as above or below the umbilicus. One propensity score was analyzed in both groups to calculate an average treatment effect (ATE) by inverse probability of treatment weighting. Logistic regression and Cox proportional hazard regression including the ATE weights were performed to examine the effect size of entry point on the frequency and timing of PPROM before balloon removal.ResultsA total of 294 patients were included. The mean ± SD gestational age at PPROM was 33.45 ± 2.01 weeks and the mean rate of PPROM before balloon removal was 25.9% (76/294). Gestational age at FETO was later in the below‐umbilicus group (mean ± SD, 29.47 ± 1.29 weeks vs 29.00 ± 1.25 weeks; P = 0.002) and the duration of FETO was longer in the above‐umbilicus group (median, 14.49 min (interquartile range (IQR), 8.00–21.00 min) vs 11.00 min (IQR, 7.00–14.49 min); P = 0.002). After balancing for possible confounding factors, trocar entry point below the umbilicus did not increase the risk of PPROM before balloon removal (adjusted odds ratio, 1.56 (95% CI, 0.89–2.74); P = 0.120) and had no effect on the timing of PPROM before balloon removal (adjusted hazard ratio, 1.56 (95% CI, 0.95–2.55); P = 0.080).ConclusionThere was no evidence that uterine entry site for FETO was correlated with the risk of PPROM before balloon removal. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.
Influence of the ancillary ligand on the crystalline structures and magnetic properties of mesaconato‐bridged Mn coordination polymers
Authors: Martínez‐Domínguez Rogelio , García‐Orozco Iván , Martínez‐Otero Diego , Morales‐Luckie Raúl A. , Sánchez‐Mendieta Víctor , Escudero Roberto 
Published: December 2023

Abstract{[Mn(mes)(dmb)(H2O)] ⋅ H2O}n (1) and [Mn(mes)(bpy)]n (2); (mes=mesaconato; dmb=5,5’‐dimethyl‐2,2’‐bipyridine; bpy=2,2’‐bipyridine), were obtained by self‐assembly solution reaction at ambient conditions, and structurally characterized by single crystal X‐ray diffraction. 1 crystallizes in an orthorhombic system with a Pbca space group and forms a one‐dimensional (1D) coordination polymer; the six‐coordinated Mn(II) centers display a distorted‐trigonal prismatic configuration. 2 crystallizes in an orthorhombic system with a P21212 space group yielding a two‐dimensional (2D) coordination array, their metal centers having a distorted octahedral geometry. Magnetic susceptibility measurements reveal that 1 is paramagnetic, while 2 shows weak antiferromagnetic coupling.
Probing electroweak phase transition in the singlet Standard Model via bbγγ and 4l channels
Authors: Zhang Wenxing , Li Hao-Lin , Liu Kun , Ramsey-Musolf Michael J. , Zeng Yonghao , Arunasalam Suntharan 
Published: December 2023

Abstract
We investigate the prospects for resonant di-Higgs and heavy Higgs production searches at the 14 TeV HL-LHC in the combination of bbγγ and 4l channels, as a probe of a possible first order electroweak phase transition in real singlet scalar extension of the Standard Model. Event selection follows those utilized in the bbγγ and 4l searches by the ATLAS Collaboration, applied to simulation using benchmark parameters that realize a strong first order electroweak phase transition. The output of discriminant analysis is implemented by numerical calculation, optimised by the joint restriction from the two channels. The prospective reach for bbγγ/4l channel could be more competitive in probing the electroweak phase transition at lower/higher resonance masses. With 3 ab−1 integrated luminosity, the combination of the bbγγ and 4l channels can discover/exclude a significant portion of the viable parameter space that realizes a strong first order phase transition when the resonance mass is heavier than 500 GeV.
Gravitational observatories
Authors: Anninos Dionysios , Galante Damián A. , Maneerat Chawakorn 
Published: December 2023

Abstract
We consider four-dimensional general relativity with vanishing cosmological constant defined on a manifold with a boundary. In Lorentzian signature, the timelike boundary is of the form σ × ℝ, with σ a spatial two-manifold that we take to be either flat or S2. In Euclidean signature we take the boundary to be S2 × S1. We consider conformal boundary conditions, whereby the conformal class of the induced metric and trace K of the extrinsic curvature are fixed at the timelike boundary. The problem of linearised gravity is analysed using the Kodama-Ishibashi formalism. It is shown that for a round metric on S2 with constant K, there are modes that grow exponentially in time. We discuss a method to control the growing modes by varying K. The growing modes are absent for a conformally flat induced metric on the timelike boundary. We provide evidence that the Dirichlet problem for a spherical boundary does not suffer from non-uniqueness issues at the linearised level. We consider the extension of black hole thermodynamics to the case of conformal boundary conditions, and show that the form of the Bekenstein-Hawking entropy is retained.
The tadpole conjecture in the interior of moduli space
Authors: Lüst Severin , Wiesner Max 
Published: December 2023

Abstract
We revisit moduli stabilization on Calabi-Yau manifolds with a discrete symmetry. Invariant fluxes allow for a truncation to a symmetric locus in complex structure moduli space and hence drastically reduce the moduli stabilization problem in its dimensionality. This makes them an ideal testing ground for the tadpole conjecture. For a large class of fourfolds, we show that an invariant flux with non-zero on-shell superpotential on the symmetric locus necessarily stabilizes at least 60% of the complex structure moduli. In case this invariant flux induces a relatively small tadpole, it is thus possible to bypass the bound predicted by the tadpole conjecture at these special loci. As an example, we discuss a Calabi-Yau hypersurface with h3,1 = 3878 and show that we can stabilize at least 4932 real moduli with a flux that induces M2-charge Nflux = 3.
Exploring the trends in flux-cored arc welding: scientometric analysis approach
Authors: Świerczyńska Aleksandra , Varbai Balázs , Pandey Chandan , Fydrych Dariusz 
Published: December 2023

AbstractFlux-cored arc welding (FCAW) is a universal group of welding methods in terms of the scope of application and automation possibilities, the share of which in various industries in many countries is still increasing. The paper presents the results of bibliographic analyses (scientometric analysis with the use of VOSviewer, Bibliometrix and CitNetExplorer tools) of a data set of 993 publications indexed in the Web of Science database on the subject of FCAW for all types of flux-cored wires. An objective and unbiased approach to analysis resulted in a relatively neutral assessment of the state of knowledge in the field of FCAW and allowed for the identification of research directions carried out in the world, the dynamics of their changes as well as research gaps and needs. The scientometric analysis approach provided a holistic picture of the development of FCAW over the last 58 years, pointing to the geographical areas where this process has been and is most intensively researched, the agencies funding this research, the most active research teams, as well as the journals that have most often published articles on this topic. The most current research directions in relation to FCAW include underwater welding, hardfacing and cladding purposes, health and safety issues, and more general topic: properties and weldability of ferrous alloys. However, among the most urgent research needs the following topics: fatigue analysis of welded joints, environmental degradation of flux-cored wires, properties and weldability of nickel alloys, development of hybrid and combined welding procedures can be listed.
Modeling, analysis, and shielding of the electric field between extra-high-voltage AC transmission lines and oil pipelines
Authors: Abdelsattar Montaser , Ziedan Hamdy A. , Elnozahy Ahmed 
Published: December 2023

AbstractThe static charges and induced voltages from extra-high-voltage alternating current transmission lines (EHVACTLs) on parallel oil pipelines (POPLs) raise the risk levels for people and animals. Thus, the objective of this paper was to reduce and/or mitigate the electric field which is concentrated on POPLs by using grounded shield wires under EHVACTLs. Three techniques are employed to reduce the electric field effects on POPLs of two distinct types of transmission lines (TLs), 500 kV and 220 kV. The first technique involves raising the tower’s height to improve the clearance space between the POPLs and the TL conductors. The second technique is increasing the horizontal distance between the POPLs and the nearest stressed conductors of the TL. The third technique involves placing shield wires beneath the stressed conductors of the EHVACTLs. The electric field under the EHVACTLs is calculated with and without the grounded shield wires using charge simulation method. The results of the first technique revealed that with increasing the tower height from 10 m to 15, 20, 25, and 30 m, the electric field decreased by 43.75%, 62.5%, 68.75%, and 75%, respectively. Herein, employing the second technique, the electric field intensity is reduced by 20% and 21% depending on the POPL placed at a distance from the right stressed conductor equal to the horizontal clearance between conductors of 500 kV and 220 kV, respectively. Besides, the results of the third technique proved that the shield wires under the EHVACTLs reduced the electric field intensity on the POPLs by 17.65% and 24.71% for 500-kV and 220-kV TLs, respectively.
Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Authors: Jin Yu , Li Xue , Wei Changling , Yuan Qiongjia 
Published: December 2023

AbstractPhysical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying neurobiological mechanisms are unclear. A total of 45 Male SPF Sprague–Dawley rats were acclimatized and then allocated into three groups, 15 in each group: the saline control (DC) group, D-gal-induced aging (DA) group, and D-gal-induced aging + exercise (DE) group. Six weeks of intraperitoneal injections of D-gal at a concentration of 100 mg/kg body weight/d was injected to establish model of aging in the DA and DE groups. Morris water maze test was implemented to evaluate the hippocampus related cognition. SOD activity and MDA was tested to assess the aging in all groups. H&E and Nissl staining was used to observe the histopathological changes of hippocampal neurons in aging rats. Quantitative real-time polymerase chain reaction, western blotting and immunofluorescence staining techniques were used to investigate the expression of synaptic genes and proteins in the hippocampus. Massarray methylation system was employed to measure the PDE-4 gene methylation level in rat hippocampal tissues. Our results demonstrated that exercise intervention improves cognitive function in D-gal-induced aging rats. The methylation of CpG sites in PDE-4 in the hippocampus was significantly increased. The physical exercise significantly increased PDE-4 gene methylation and effectively decreased PDE-4 gene and protein expression. These beneficial behavioral and morphological effects were attributed to PDE-4 methylation, which was activated cAMP/PKA/CREB pathway and improved synaptic plasticity. Exercise induced PDE-4 methylation is key mechanism underpinning the amelioration of learning/memory impairment, suggesting the potential efficacy of physical exercise training in delaying brain aging.
Storm identification for high-energy wave climates as a tool to improve long-term analysis
Authors: Kümmerer Vincent , Ferreira Óscar , Fanti Valeria , Loureiro Carlos 
Published: December 2023

AbstractCoastal storms can cause erosion and flooding of coastal areas, often accompanied by significant social-economic disruption. As such, storm characterisation is crucial for an improved understanding of storm impacts and thus for coastal management. However, storm definitions are commonly different between authors, and storm thresholds are often selected arbitrarily, with the statistical and meteorological independence between storm events frequently being neglected. In this work, a storm identification algorithm based on statistically defined criteria was developed to identify independent storms in time series of significant wave height for high wave energy environments. This approach proposes a minimum duration between storms determined using the extremal index. The performance of the storm identification algorithm was tested against the commonly used peak-over-threshold. Both approaches were applied to 40 and 70-year-long calibrated wave reanalyses datasets for Western Scotland, where the intense and rapid succession of extratropical storms during the winter makes the identification of independent storm events notably challenging. The storm identification algorithm provides results that are consistent with regional meteorological processes and timescales, allowing to separate independent storms during periods of rapid storm succession, enabling an objective and robust storm characterisation. Identifying storms and their characteristics using the proposed algorithm allowed to determine a statistically significant increasing long-term trend in storm duration, which contributes to the increase in storm wave power in the west of Scotland. The coastal storm identification algorithm is found to be particularly suitable for high-energy, storm-dominated coastal environments, such as those located along the main global extratropical storm tracks.
A numerical study on the visco-plastic regularization of a rate-independent strain gradient crystal plasticity formulation
Authors: Lara Jose , Steinmann Paul 
Published: December 2023

AbstractA common practice in computational investigations of rate-independent plasticity is to approximate the rate-independent behavior by a visco-plastic regularization. As the fidelity of the approximation increases, the numerical solution of the non-linear problem becomes challenging and it can eventually lead to divergence; thus, there is a numerical limit to the regularization parameter. This limit may be exacerbated by complex material models and critical values of material parameters. Due to these constraints, the regularization may be rendered insufficient and the artificially introduced rate-dependency may lead to a behavior that can be mistakenly attributed to the material model and that we thus identify as spurious in a rate-independent context. To study these spurious effects and their onset, here the problem of an infinite strip under shear loading is numerically solved using a visco-plastic regularized gradient crystal plasticity formulation. The required accuracy of the rate-dependent approximation is found to vary with respect to the type of loading. Furthermore, a set of sigmoid functions used for the regularization is investigated and a subset is shown to deliver improved approximation of the rate-independent case.
Effectiveness of manual lymphatic drainage in intensive phase I therapy of breast cancer–related lymphedema—a retrospective analysis
Authors: Kasseroller Renato G. , Brenner Erich 
Published: December 2023

Abstract
Background
The standard therapy for lymphedema of any origin is complex physical decongestive therapy (CDT). It comprises manual lymph drainage (MLD), compression therapy (CT), exercise therapy (ET), skincare, and patient education. Additionally, intermittent pneumatic compression (IPC) can be applied. However, the contribution of MLD to decongestion is repeatedly questioned.

Patients and methods
This study re-analyzes a previous study during a 3-week decongestion period, comparing two different types of compression bandaging at the weekend. Sixty-one patients with unilateral breast cancer–related lymphedema were included. The patients received the same therapy (CDT + IPC) except for the different weekend compression bandaging. MLD was performed twice a day on weekdays. The volume of the affected arm was measured on days 1, 5, 8, 12, 15, 19, and 22. For the analysis, the data of both study groups were pooled.

Results
During the week, the patients showed a significant volume reduction (− 155.23 mL (week 1), − 101.02 mL (week 2), − 61.69 mL (week 3), respectively; p < 0.001 each) with a high effect size. On the weekends without MLD, they showed a slight, but also significant increase (12.08 mL (weekend 1), 8.36 mL (weekend 2), 4.33 mL (weekend 3), respectively; p < 0.001 each) with a medium effect size.

Conclusions
We showed a strong effect of MLD on volume reduction. Differences from other studies are the larger study population and the more intensive application of MLD. If applied intensively, MLD is strongly decongestive during a 3-week decongestion therapy for breast cancer–related lymphedema.
Exercising the “Right to Repair”: A Customer’s Perspective
Authors: Marikyan Davit , Papagiannidis Savvas 
Published: December 2023

AbstractConcerns over the carbon footprint resulting from the manufacturing, usage and disposal of hardware have been growing. The right-to-repair legislation was introduced to promote sustainable utilisation of hardware by encouraging stakeholders to prolong the lifetime of products, such as electronic devices. As there is little empirical evidence from a consumer perspective on exercising the right to repair, this study aims firstly to examine the factors that underpin consumers’ intention to repair their hardware and secondly to investigate the perceived outcomes of repair practices. Based on 510 responses, the results showed that intention to repair is dependent on three groups of factors, namely the facilitators of pro-environmental behaviour, repair-related factors and beliefs about legislation. If consumers have a stronger intention to repair, they have a stronger feeling of emotional self-assurance, satisfaction with the repair decision and the technology manufacturer, an intention to engage with the manufacturer and a positive perception of a repaired device’s performance. The findings contribute to the literature on sustainable behaviour and the right to repair, offering insight for policymakers and manufacturers about the strategies facilitating the wider adoption of repair practices.
An early indicator index of tornadic storms for Euro-Mediterranean region
Authors: Mihliardic Omer Kutay , Sirdas Sevinc Asilhan , Kaya Serkan 
Published: December 2023

AbstractTornadoes are the most violent and destructive of all the severe weather phenomena that localized convective storms produce. There is a requirement in operational meteorology increasing nowadays that an indicator index which allows to reduce the uncertainty of severe convective storms and tornadoes in the scope of climate change adaptation strategies. The main intention is not to replace or substitute mesoscale modeling approaches, or composite indexes, but to warn operationally to draw attention to the Eastern Mediterranean and Türkiye in particular a few days in advance. The development of some indicators using atmospheric variables can undertake a crucial role by enabling such numerical models to be run only at certain time intervals, thus enduring lower computational costs. In this study, Eastern Mediterranean oscillation index (EMEDOi) has been developed in order to be able to detect the presence of ULLs (upper-level low) and frontogenesis approach is employed for selected tornadic storm events in Türkiye. EMEDOi has 7 different its variations (members) which these members have been developed to detect differences depending on the entry directions of cyclones and storms influencing Türkiye from the west of the country. In line with the GDAS data analysis, values of geopotential height are derived for the requirement of EMEDOi in a limited area. A few of the results from the study are as in the following: 86% of the trained tornado events revealed that the EMEDO-Oper index was in negative phase at the time a tornado was reported, regardless of whether the events featured a supercell mesoscale convective storm or a frontal movement. The hourly period until the local minimum is obtained can be described and characterized as the process by which the EMEDO-Oper index value decreases continuously. The time required to reach the local minimum varies based on the tornado occurrence. Based on the tornadic storm scenario in the test cluster in 2022 and the train cluster, this timeframe is predicted to be roughly 33.2 h on average. In western Türkiye, there is a 79% chance of a tornado occurring between six and forty-two hours after the EMEDO-Oper index reaches its local minimum. In particular, the projected chance for this period is 63% between 12 and 30 h after the local minimum is obtained. Besides, the majority of the tornado incidents with EMEDO-Oper values below − 0.75 were evaluated. After an EMEDO-Oper index value falls below that threshold, it is likely to forecast the risk period of a tornado in Türkiye with a probability of 79% and the local minimum point must be identified.