bluuebunny/crossref_metadata_2025_split huggingface dataset:
The single‐cell evolution trajectory presented different hypoxia heterogeneity to reveal the carcinogenesis of genes in clear cell renal cell carcinoma: Based on multiple omics and real experimental verification
Authors: Ma Baoluo , Qin Linghui , Sun Zhou , Wang Jingyu , Tran Lisa Jia , Zhang Jing , Ye Fangdie , Liu Yan , Chen Min 
Published: October 2023

AbstractIntroductionClear cell renal cell carcinoma (ccRCC) is the most prevalent and aggressive subtype of renal cell carcinoma, originating from renal tubular epithelial cells in the kidney. Hypoxia proves to be a feature commonly observed in solid tumors, leading to increased resistance to treatment and tumor progression.MethodsscRNA‐seq data were procured from GSE159115 data set. We utilized UMAP and NMF algorithm for clustering and dimensionality reduction. The FindAllMarkers function was used to compare various groups and identify potential hypoxia marker genes. A series of in vitro experiments, including CFA, flow cytometry targeting cell cycle, CCK‐8, and EDU, was applied to investigate how ANGPTL4 regulated the ccRCC progression. Two cell lines of ccRCC cells, 786‐O and Caki, were used for si‐ANGPTL4 transfection.ResultsWe annotated a total of a total of 6 cell clusters, namely ccRCC malignant cells, T cells, endothelial cells, myeloid cells, smooth muscle cells, and B cells. We observed higher levels of hypoxia‐score in the ccRCC malignant cells, while lowest hypoxia‐score in T and B cells. We detected multiple hypoxia‐related subclusters of TME cells in ccRCC, among which S100A4 CD8+ T cells and nonhypoxia CD8+ T cells were found with a marked elevation of T cell inhibitory gene score. We identified that ANGPTL4+ endothelial cells might function as an integrative role in tumor angiogenesis. Multiple TME subclusters showed high potency in stratification of the prognosis of ccRCC patients. Moreover, by a series of in vitro experiment, we found ANGPTL4 regulated the ccRCC cell proliferation, probably through ERK/P38 pathway.ConclusionWe discerned multiple hypoxia‐related subclusters of TME cells in ccRCC, which displayed distinct functional features and great potency in predicting prognosis of ccRCC patients. We identified the role of ANGPTL4 in regulating ccRCC proliferation via ERK/p38 pathway.
Taxogenomic placement of Rasporella oleae and Rasporella dianae gen. and spp. nov., two insect associated yeast species
Authors: Čadež Neža , Boundy‐Mills Kyria , Botha Alfred , Kachalkin Aleksey , Dlauchy Dénes , Péter Gábor 
Published: October 2023

AbstractDuring the course of independent studies in Europe, North America, and Africa, seven yeast strains were isolated from insect frass, decaying wood, tree flux, and olive oil sediment. Phylogenetic analysis of two barcoding DNA regions (internal transcribed spacer and the D1/D2 domain of the LSU rRNA gene) revealed that they belong to two closely related undescribed species distinct from all genera in the family Debaryomycetaceae. For reliable taxonomic placement the genomes of four strains of the two novel species and six type strains of closely related species were sequenced. Orthologous genes from 54 genomes of representatives of the Pichiomycetes and 23 outgroup taxa were concatenated to construct a fully supported phylogenetic tree. Consistent with the assumptions, we found that the two new species belong to a novel genus. In addition, the delimitation of the novel species was supported by genetic distance calculations from average nucleotide identity (ANI) and digital DNA:DNA hybridization (dDDH) values. The physiological characterization of the novel species was generally consistent with their genomic content. All strains had two alleles encoding secretory lipase in either two or three copies depending on the species. However, lipolytic activity was detected only in strains with three copies of the secretory lipase gene. Nevertheless, lipolytic activity might be related to their association with the insect gut. Based on these results, formal descriptions of the new genus Rasporella gen. nov. and of two new species Rasporella dianae sp. nov. (holotype UCDFST 68‐643T, MycoBank no.: 850238) and Rasporella oleae sp. nov. (holotype ZIM 2471T, MycoBank no.: 850126) are provided.
Anlage des Forschungsprojektes
Authors: Wittfeld Meike 
Published: October 2023

ZusammenfassungFür diese Studie wurden ein exploratives Vorgehen und ein qualitativ-rekonstruktiver Ansatz gewählt, „um dem Untersuchungsfeld in seiner Komplexität und der ihm eigenen Struktur möglichst offen zu begegnen“ (Zeitler/Heller/Asbrand 2012: 49). Im Folgenden sollen zunächst die methodologischen und methodischen Bezugspunkte der Forschungsarbeit expliziert werden (3.1).
Anlässe der Thematisierung sexueller Gewalt durch pädagogische Fachkräfte – eine Einleitung
Authors: Wittfeld Meike 
Published: October 2023

ZusammenfassungDas vorangegangene Kapitel hat gezeigt, dass die pädagogischen Fachkräfte sich zunächst von der Gewalttat distanzieren müssen, um im Weiteren über sexuelle Gewalt als Thema sprechen zu können. Dieses Kapitel rekonstruiert nun Anlässe der Thematisierung. Die Beschreibungen und Erzählungen, dass das Thema in der Handlungspraxis relevant ist, sind in den Gruppendiskussionen in vielfältiger Form zu finden. In der Kontrastierung lassen sich über die Anlässe starke Gemeinsamkeiten und auch einige Differenzen zwischen den Teams herausarbeiten.
Institutionelle Bedingungen als Anlass der Thematisierung von sexueller Gewalt in Institutionen: „aber in anderen gruppen, wird anders gearbeitet, da sind andere konzepte“
Authors: Wittfeld Meike 
Published: October 2023

ZusammenfassungBereits im vorangegangenen Kapitel wurde deutlich, dass es zwischen den Teams große Unterschiede in den Orientierungen hinsichtlich des organisationalen Umgangs mit der medialen Berichterstattung gibt. Weitere Anlässe der Thematisierung sexueller Gewalt werden in den Bedingungen der Institution selbst verortet. Dabei geht es einerseits um organisationale und pädagogische Bedingungen, die sich auf die stationäre Kinder- und Jugendhilfe im Allgemeinen beziehen lassen und andererseits um solche Bedingungen, die für spezifische organisationale Konstellationen gelten. Alle Bedingungen werden von den Teams als Bedingungen für das Entstehen von sexueller Gewalt und/oder der Möglichkeit, unter falschen Verdacht zu geraten, thematisiert. Dabei wird sowohl darauf eingegangen, dass einige Bedingungen Schutz, andere Risiken bergen und manche auch ambivalent sind und sowohl schützen als auch riskant sind.
New Physics in CP violating and flavour changing quark dipole transitions
Authors: Fajfer Svjetlana , Kamenik Jernej F. , Košnik Nejc , Smolkovič Aleks , Tammaro Michele 
Published: October 2023

Abstract
We explore CP-violating (CPV) effects of heavy New Physics in flavour-changing quark dipole transitions, within the framework of Standard Model Effective Field Theory (SMEFT). First, we establish the relevant dimension six operators and consider the Renormalisation Group (RG) evolution of the appropriate Wilson coefficients. We investigate RG-induced correlations between different flavour-violating processes and electric dipole moments (EDMs) within the Minimal Flavour Violating and U(2)3 quark flavour models. At low energies, we set bounds on the Wilson coefficients of the dipole operators using CPV induced contributions to observables in non-leptonic and radiative B, D and K decays as well as the neutron and electron EDMs. This enables us to connect observable CPV effects at low energies and general NP appearing at high scales. We present bounds on the Wilson coefficients of the relevant SMEFT operators at the high scale Λ = 5 TeV, and discuss most sensitive CPV observables for future experimental searches.
Microstrata
Authors: Ganchev Bogdan , Giusto Stefano , Houppe Anthony , Russo Rodolfo , Warner Nicholas P. 
Published: October 2023

AbstractMicrostrata are the non-extremal analogues of superstrata: they are smooth, non-extremal (non-BPS) solitonic solutions to IIB supergravity whose deep-throat limits approximate black holes. Using perturbation theory and numerical methods, we construct families of solutions using a consistent truncation to three-dimensional supergravity. The most general families presented here involve two continuous parameters, or amplitudes, and four quantized parameters that set the angular momenta and energy levels. Our solutions are asymptotic to the vacuum of the D1-D5 system: AdS3×S3× 𝕋4. Using holography, we show that the they are dual to multi-particle states in the D1-D5 CFT involving a large number of mutually non-BPS supergravitons and we determine the anomalous dimensions of these states from the binding energies in supergravity. These binding energies are uniformly negative and depend non-linearly on the amplitudes of the states. In one family of solutions, smoothness restricts some of the fields to lie on a special locus of the parameter space. Using precision holography we show that this special locus can be identified with the multi-particle states constructed via the standard OPE of the single-particle constituents. Our numerical analysis shows that microstrata are robust at large amplitudes and the solutions can be obtained to very high precision.
Linking within- and between-host scales for understanding the evolutionary dynamics of quantitative antimicrobial resistance
Authors: Mann-Manyombe Martin L. , Mendy Abdoulaye , Seydi Ousmane , Djidjou-Demasse Ramsès 
Published: October 2023

AbstractUnderstanding both the epidemiological and evolutionary dynamics of antimicrobial resistance is a major public health concern. In this paper, we propose a nested model, explicitly linking the within- and between-host scales, in which the level of resistance of the bacterial population is viewed as a continuous quantitative trait. The within-host dynamics is based on integro-differential equations structured by the resistance level, while the between-host scale is additionally structured by the time since infection. This model simultaneously captures the dynamics of the bacteria population, the evolutionary transient dynamics which lead to the emergence of resistance, and the epidemic dynamics of the host population. Moreover, we precisely analyze the model proposed by particularly performing the uniform persistence and global asymptotic results. Finally, we discuss the impact of the treatment rate of the host population in controlling both the epidemic outbreak and the average level of resistance, either if the within-host scale therapy is a success or failure. We also explore how transitions between infected populations (treated and untreated) can impact the average level of resistance, particularly in a scenario where the treatment is successful at the within-host scale.
Unravelling the pre-eruptive conditions of the rhyolitic Šumovit Greben lava dome from clinopyroxene-dominant glomeroporphyritic clots
Authors: Molnár Kata , Lahitte Pierre , Döncző Boglárka , Arató Róbert , Szepesi János , Benkó Zsolt , Nomade Sebastien , Gätjen Jochen , Dibacto Stéphane , Temovski Marjan 
Published: October 2023

AbstractDetailed analyses of mineral composition and whole-rock geochemical data helped to unravel the volcanic plumbing system beneath the rhyolitic Šumovit Greben lava dome, the westernmost member of the Kožuf-Voras volcanic system (N. Macedonia). It is characterized by high SiO2 content (> 70 wt%) coupled with low MgO (< 1 wt%) and Sr (< 500 ppm) suggesting fractionation of clinopyroxene and plagioclase at depth forming a crystal mush and a crystal-poor rhyolitic lens by fractional crystallization and melt extraction on top of it. The crystal mush is composed of mainly clinopyroxene, biotite and plagioclase, whereas sanidine and plagioclase are the most abundant phenocrysts of the rhyolitic lens. The main dome forming event occurred at ca. 2.9 Ma, which sampled the crystal-poor rhyolitic lens. After a short quiescence time, an explosive eruption occurred depositing a massive lapilli tuff layer northwest of the lava dome, and an extrusion of a small-volume lava flow on the northern side of the lava dome at ca. 2.8 Ma. This latter sampled also the crystal mush, as it contains abundant glomeroporphyritic clots of clinopyroxene ± plagioclase ± biotite. The clinopyroxene phenocrysts are chemically homogeneous, their crystallization temperature is ca. 900 °C representing the crystal mush, whereas the plagioclase and the sanidine crystallized at a lower temperature (ca. 790 °C) representing the rhyolitic lens. Noble gas isotopic composition of the clinopyroxene indicate no mantle-derived fluids (< 0.5%) having an R/Ra of ca. 0.04 Ra. The rejuvenation of the system probably occurred due to implementation of mafic magma at depth leading to a heat transfer and partial melting of the cumulate. This led to crystallization of Ba-rich rims of the sanidine and An- and Sr-rich rims of the plagioclase. The crystal mush zone beneath Šumovit Greben might be connected to the nearby, more mafic volcanic centers, and the eruption of Šumovit Greben could have been the start of the last cycle in the lifetime of the Kožuf-Voras volcanic system.
Petrological and geochemical evidence for a hot crystallization path and a recharge filtering bypass at Antimilos, Milos volcanic field, Greece
Authors: Xydous Stamatios , Baziotis Ioannis P. , Klemme Stephan , Bizimis Michael , Vroon Pieter Z. , Berndt Jasper , Day James M. D. , Asimow Paul D. 
Published: October 2023

AbstractAntimilos volcano in the South Aegean Volcanic Arc, Greece, comprises an andesite–dacite suite that follows a distinct evolutionary path than the main edifice of the Milos volcanic field, despite their proximity. Petrographic and geochemical analyses reveal that basaltic andesite to low-Si dacite lavas have similar phenocryst assemblages that indicate crystallization from hot, relatively dry magmas in an upper crustal storage region. Rare antecrystic high-Mg# clinopyroxene cores with low Y, low Dy, and high Sr contents record the cryptic involvement of amphibole, a phase nominally absent from the erupted products, in the deeper parts of the plumbing system. Low temperature antecrysts with textures recording various degrees of disequilibrium suggest a protracted history of interaction between the upper crustal reservoir and deeper mafic melts, forming mobile hybrid magmas that consequently erupt as highly mingled, crystal-rich lava domes. Antimilos magmas seem to have escaped recharge filtering in the upper crust and prolonged stalling, which is the process that is probably responsible for the paucity of mafic eruptions in the rest of the Milos volcanic system. Large extensional structures offshore of Antimilos promote rapid ascent of mafic melts, inhibiting prolonged stalling and interaction with the arc crust. This model highlights the dominant role of the regional stress field in generating petrologically distinct suites in the marginal parts of some volcanic fields.
Indirect plant-mediated interactions between heterospecific parasitoids that develop in different caterpillar species
Authors: Cuny Maximilien A. C. , Pierron Romain , Gols Rieta , Poelman Erik H. 
Published: October 2023

AbstractParasitoids induce physiological changes in their herbivorous hosts that affect how plants respond to herbivory. The signature of parasitoids on induced plant responses to feeding by parasitized herbivores indirectly impacts insect communities interacting with the plant. The effect may extend to parasitoids and cause indirect interaction between parasitoids that develop inside different herbivore hosts sharing the food plant. However, this type of interactions among parasitoid larvae has received very little attention. In this study, we investigated sequential and simultaneous plant-mediated interactions among two host–parasitoid systems feeding on Brassica oleracea plants: Mamestra brassicae parasitized by Microplitis mediator and Pieris rapae parasitized by Cotesia rubecula. We measured the mortality, development time, and weight of unparasitized herbivores and performance of parasitoids that had developed inside the two herbivore species when sharing the food plant either simultaneously or sequentially. Plant induction by parasitized or unparasitized hosts had no significant effect on the performance of the two herbivore host species. In contrast, the two parasitoid species had asymmetrical indirect plant-mediated effects on each other’s performance. Cotesia rubecula weight was 15% higher on plants induced by M. mediator-parasitized hosts, compared to control plants. In addition, M. mediator development time was reduced by 30% on plants induced by conspecific but not heterospecific parasitoids, compared to plants induced by its unparasitized host. Contrary to sequential feeding, parasitoids had no effect on each other’s performance when feeding simultaneously. These results reveal that indirect plant-mediated interactions among parasitoid larvae could involve any parasitoid species whose hosts share a food plant.
Cohesional behaviours in pyroclastic material and the implications for deposit architecture
Authors: Walding Nemi , Williams Rebecca , Rowley Pete , Dowey Natasha 
Published: October 2023

AbstractPyroclastic density currents (PDCs) are hazardous, multiphase currents of heterogeneous volcanic material and gas. Moisture (as liquid or gas) can enter a PDC through external (e.g., interaction with bodies of water) or internal (e.g., initial eruptive activity style) processes, and the presence of moisture can be recorded within distinct deposit layers. We use analogue experiments to explore the behaviour of pyroclastic material with increasing addition of moisture from 0.00–10.00% wt. Our results show that (1) the cohesivity of pyroclastic material changes with the addition of small amounts of moisture, (2) small increases in moisture content change the material properties from a free-flowing material to a non-flowable material, (3) changes in moisture can affect the formation of gas escape structures and fluidisation profiles in pyroclastic material, (4) gas flow through a deposit can lead to a moisture profile and resulting mechanical heterogeneity within the deposit and (5) where gas escape structure growth is hindered by cohesivity driven by moisture, pressure can increase and release in an explosive fashion. This work highlights how a suite of varied gas escape morphologies can form within pyroclastic deposits resulting from moisture content heterogeneity, explaining variation in gas escape structures as well as providing a potential mechanism for secondary explosions.
Patients’ views and experiences on the supported self-management/patient-initiated follow up pathway for breast cancer
Authors: Jenkins Valerie , Starkings Rachel , Teoh May , May Shirley , Bloomfield David , Zammit Charles , Elwell-Sutton Debbie , Betal Dibendu , Finlay Judith , Nicholson Kay , Kothari Manish , Santos Regina , Stewart Elaine , Bell Stephanie , McKinna Fiona , Matthews Lucy 
Published: October 2023

Abstract
Purpose
To explore patients’ expectations and experience of Supportive Self-Management (SSM)/ Patient Initiated Follow Up (PIFU) following breast cancer treatments over a 12-month period.

Methods
In total, 32/110 (29%) patient participants in the PRAGMATIC (Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer) study were interviewed at baseline, 3, 6, 9 and 12 months. Interviews in this sub-study used a mix-methods approach to explore understanding of the pathway, confidence in self-management, triggers to seek help and/or re-engage with the clinical breast team and impact of the COVID-19 pandemic. Responses to pre-assigned categories were summarised as counts/ percentages and collated in tabular or graphic format. Free responses were recorded verbatim and reviewed using framework analysis.

Results
Participants regarded the SSM/PIFU pathway as a way to save time and money for them and the National Health Service (NHS) (14/32; 44%) and as a means of assuming responsibility for their own follow-up (18/32; 56%). Most maintained (very/somewhat) confidence in managing their BC follow-up care (baseline 31/32, 97%; 12 months 29/31, 93%). During the year, 19% (5/26) stopped endocrine therapy altogether because of side effects. Qualitative analysis revealed general satisfaction with SSM/PIFU and described the breast care nurses as reassuring and empathic. However, there was a lingering anxiety about identifying signs and symptoms correctly, particularly for those with screen-detected cancers. There was also uncertainty about who to contact for psychological support. The COVID-19 pandemic discouraged some participants from contacting the helpline as they did not want to overburden the NHS.

Conclusions
The results show that during the first year on the SSM/PIFU pathway, most patients felt confident managing their own care. Clinical teams should benefit from understanding patients’ expectations and experiences and potentially modify the service for men with BC and/or those with screen-detected breast cancers.
Altruistic preferences in global emission games
Authors: Zapata A. , Mármol A. M. , Monroy L. , Caraballo M. A. 
Published: October 2023

AbstractThis paper analyses the impact of altruism on the individual country goverments’ incentives to reduce global polluting emissions. The game theory perspective provides insights into the strategic decision-making processes of the governments regarding the problem of climate change. We propose a model of strategic interactions among countries in which each government is concerned with its own benefit, as well as with the benefits of all the other countries.The model is a vector-valued non-cooperative game that permits the representation of situations in which the preferences of the governments are incomplete and there is imprecision about the degrees of altruism. The focus is on the identification of the potential equilibria that will eventually be reached when the governments show different attitudes towards other countries or groups of countries. As a result, we show that the incorporation of altruism into the model produces equilibria with a positive effect on the reduction of emissions.