bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of perceptual complexity on road crossing decisions in younger and older adults
Authors: Nicholls Victoria I. , Wiener Jan , Meso Andrew Isaac , Miellet Sebastien 
Published: January 2024

AbstractCognitive abilities decline with healthy ageing which can have a critical impact on day-to-day activities. One example is road crossing where older adults (OAs) disproportionally fall victim to pedestrian accidents. The current research examined two virtual reality experiments that investigated how the complexity of the road crossing situation impacts OAs (N = 19, ages 65–85) and younger adults (YAs, N = 34, ages 18–24) with a range of executive functioning abilities (EFs). Overall, we found that OAs were able to make safe crossing decisions, and were more cautious than YAs. This continued to be the case in high cognitive load situations. In these situations, safe decisions were associated with an increase in head movements for participants with poorer attention switching than participants with better attention switching suggesting these groups developed compensation strategies to continue to make safe decisions. In situations where participants had less time to make a crossing decision all participants had difficulties making safe crossing decisions which was amplified for OAs and participants with poorer EFs. Our findings suggest more effort should be taken to ensure that road crossing points are clear of visual obstructions and more speed limits should be placed around retirement or care homes, neither of which are legislated for in the UK and Australia.
The relationship between blood vitamin A levels and diabetic retinopathy: a population-based study
Authors: Choi Yu-Jin , Kwon Jin-Woo , Jee Donghyun 
Published: January 2024

AbstractWe assessed the relationship between blood vitamin A levels and the risk of diabetic retinopathy. The study was population-based epidemiological study for 11,727 participants aged 40 or older who participated in the Korean National Health and Nutrition Examination Survey. Vitamin A in the blood was classified into quartiles. Diabetic retinopathy was diagnosed by the Early Treatment for Diabetic Retinopathy Study. After adjusting confounding variables such as age, sex, smoking, cholesterol, diabetes prevalence period, glycated hemoglobin levels, and high blood pressure, the odd ratio (OR) of vitamin A at quartile level 4 for diabetic retinopathy was 0.32 (95% confidence interval [CI], 0.14–0.72, P for trend < 0.001). In male, the OR of quartile 3 level vitamin A for diabetic retinopathy was 0.11 (95% CI, 0.01–0.69, P for trend = 0.010). In adults under the age of 60, the OR of vitamin A at quartile level 3 for diabetic retinopathy was 0.10. (95% CI, 0.03–0.29, P for trend < 0.001). Serum vitamin A high levels are associated with low risk of diabetic retinopathy. Particularly, there is a more effective relationship in male and adults under the age of 60.
Longitudinal evaluation of advanced glaucoma: ten year follow-up cohort study
Authors: Shin Young In , Jeong Yoon , Huh Min Gu , Kim Young Kook , Park Ki Ho , Jeoung Jin Wook 
Published: January 2024

AbstractThis study focused on patients with advanced open-angle glaucoma (OAG) and aimed to identify key factors for monitoring them. We included 127 such patients who were followed for seven years or more, undergoing annual ophthalmic examinations. Glaucoma progression was defined as a deterioration in either structure or function. The progression rates and risk factors were evaluated. The patients were divided into upper- and lower-half subgroups based on the reduction in intraocular pressure (IOP) from the baseline. Over an 11-year period, glaucoma progression was detected in 59 eyes (46.5%). The rate of change in mean deviation (MD) was − 0.43 dB/year for the entire population; − 0.67 dB/year for progressors; and − 0.20 dB/year for non-progressors. Hypertension and disc hemorrhage (DH) were more common in progressors compared to non-progressors (45.8 vs. 23.5%, 11.9 vs. 1.5%; P = 0.008 and P = 0.016). Multivariate Cox’s proportional hazard model revealed that the presence of DH and a better baseline MD were associated with glaucoma progression. Additionally, patients with a higher percentage reduction in IOP (> 20.94%) had a lower risk of progression compared to those with less reduction. Inadequate IOP reduction, better baseline MD, presence of DH, and lower central corneal thickness were identified as risk factors for progression in advanced OAG patients.
Extrapolating tipping points and simulating non-stationary dynamics of complex systems using efficient machine learning
Authors: Köglmayr Daniel , Räth Christoph 
Published: January 2024

AbstractModel-free and data-driven prediction of tipping point transitions in nonlinear dynamical systems is a challenging and outstanding task in complex systems science. We propose a novel, fully data-driven machine learning algorithm based on next-generation reservoir computing to extrapolate the bifurcation behavior of nonlinear dynamical systems using stationary training data samples. We show that this method can extrapolate tipping point transitions. Furthermore, it is demonstrated that the trained next-generation reservoir computing architecture can be used to predict non-stationary dynamics with time-varying bifurcation parameters. In doing so, post-tipping point dynamics of unseen parameter regions can be simulated.
The emerging role of ectodermal neural cortex 1 in cancer
Authors: He Lingling , Zhang Chiyu , He Wenjing , Xu Minjuan 
Published: January 2024

AbstractEctodermal neural cortex 1 (ENC1) is a protein that plays a crucial role in the regulation of various cellular processes such as cell proliferation, differentiation, and apoptosis. Numerous studies have shown that ENC1 is overexpressed in various types of cancers, including breast, lung, pancreatic, and colorectal cancer, and its upregulation is correlated with a poorer prognosis. In addition to its role in cancer growth and spreading, ENC1 has also been linked to neuronal process development and neural crest cell differentiation. In this review, we provide an overview of the current knowledge on the relationship between ENC1 and cancer. We discuss the molecular mechanisms by which ENC1 contributes to tumorigenesis, including its involvement in multiple oncogenic signaling pathways. We also summarize the potential of targeting ENC1 for cancer therapy, as its inhibition has been shown to significantly reduce cancer cell invasion, growth, and metastasis. Finally, we highlight the remaining gaps in our understanding of ENC1’s role in cancer and propose potential directions for future research.
A network analysis of early arthropod evolution and the potential of the primitive
Authors: Ostachuk Agustín 
Published: January 2024

AbstractIt is often thought that the primitive is simpler, and that the complex is generated from the simple by some process of self-assembly or self-organization, which ultimately consists of the spontaneous and fortuitous collision of elementary units. This idea is included in the Darwinian theory of evolution, to which is added the competitive mechanism of natural selection. To test this view, we studied the early evolution of arthropods. Twelve groups of arthropods belonging to the Burgess Shale, Orsten Lagerstätte, and extant primitive groups were selected, their external morphology abstracted and codified in the language of network theory. The analysis of these networks through different network measures (network parameters, topological descriptors, complexity measures) was used to carry out a Principal Component Analysis (PCA) and a Hierarchical Cluster Analysis (HCA), which allowed us to obtain an evolutionary tree with distinctive/novel features. The analysis of centrality measures revealed that these measures decreased throughout the evolutionary process, and led to the creation of the concept ofevolutionary developmental potential. This potential, which measures the capacity of a morphological unit to generate changes in its surroundings, is concomitantly reduced throughout the evolutionary process, and demonstrates that the primitive is not simple but has a potential that unfolds during this process. This means for us the first empirical evolutionary evidence of our theory of evolution as a process of unfolding.
Impacts of body weight change on treatment outcomes in patients with multidrug-resistant tuberculosis in Northwest Ethiopia
Authors: Wagnew Fasil , Alene Kefyalew Addis , Kelly Matthew , Gray Darren 
Published: January 2024

AbstractMeasuring body weight during therapy has received insufficient attention in poor resource settings like Ethiopia. We aimed to investigate the association between weight change during therapy and treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB) in northwest Ethiopia. This retrospective cohort study analysed data from patients with MDR-TB admitted between May 2015 to February 2022 at four treatment facilities in Northwest Ethiopia. We used the joint model (JM) to determine the association between weight change during therapy and treatment outcomes for patients with MDR-TB. A total of 419 patients with MDR-TB were included in the analysis. Of these, 265 (63.3%) were male, and 255 (60.9%) were undernourished. Weight increase over time was associated with a decrease in unsuccessful treatment outcomes (adjusted hazard ratio (AHR): 0.96, 95% CI: 0.94 to 0.98). In addition, patients with undernutrition (AHR: 1.72, 95% CI: 1.10 to 2.97), HIV (AHR:1.79, 95% CI: 1.04 to 3.06), and clinical complications such as pneumothorax (AHR: 1.66, 95% CI: 1.03 to 2.67) were associated with unsuccessful treatment outcomes. The JM showed a significant inverse association between weight gain and unsuccessful MDR-TB treatment outcomes. Therefore, weight gain may be used as a surrogate marker for good TB treatment response in Ethiopia.
Performance evaluation of a firewall service based on virtualized IncludeOS unikernels
Authors: Kurek Tytus , Niemiec Marcin , Lason Artur 
Published: January 2024

AbstractNetwork function virtualization technology has long moved beyond the experimental phase to become a standard in the implementation of modern telecommunications networks. It is anticipated that in the near future all network services will be implemented in software based on cloud-native architecture. As a result, telecommunications service providers have started exploring containers and unikernels as alternative technologies to traditional virtual machines. This paper presents performance evaluation of a firewall service based on IncludeOS unikernels. It shows that IncludeOS unikernels achieve promising performance results compared to Ubuntu-based virtual machines and containers. The presented evaluation is based on a number of experiments and benchmarks performed to investigate how different parameters of a firewall service change depending on the number of firewall rules.
Optimal design and experimental research on the spiral groove wheel fertilizer apparatus
Authors: Wen Fujun , Wang Honghai , Zhou Lai , Zhu Qingchuang 
Published: January 2024

AbstractAs the "core" of fertilizer machinery, the fertilizer apparatus has a significant impact on the effect of fertilization operation. At present, the straight-grooves type external groove wheel fertilizer apparatus is widely used, which has the problem that the fertilizer flow fluctuates periodically and is not conducive to precision fertilization. Therefore a kind of the spiral groove wheel fertilizer apparatus is proposed in the paper, and the designed fertilizer apparatus is experimented and optimized by using Design-Expert Software 10 and a self-made fertilizer experiment bench. Taking the fertilization amount and the variation coefficient of fertilization amount as the experiment index, the interaction effects of the groove radius, spiral rising angle, groove wheel rotation speed, and fertilizer tongue inclination of the spiral groove wheel type fertilizer wheel on the fertilization performance are analyzed. The quadratic regression models of multiple factors of the fertilization amount and the variation coefficient of fertilization amount are established. Through optimization and experiment validation, the optimal combination of parameters is determined as follows: the groove radius is 13.5 mm, the spiral rising angle is 62°, the groove wheel rotation speed is 29.4 r/min, the fertilizer tongue inclination is 5°, the fertilization amount is 17.810 g and the variation coefficient of fertilization amount is 5.60%.
Anticipating trade-offs and promoting synergies between small-scale fisheries and aquaculture to improve social, economic, and ecological outcomes
Authors: Mansfield Elizabeth J. , Micheli Fiorenza , Fujita Rod , Fulton Elizabeth A. , Gelcich Stefan , Battista Willow , Bustamante Rodrigo H. , Cao Ling , Daniels Benjamin N. , Finkbeiner Elena M. , Gaines Steven , Peckham Hoyt , Roche Kelly , Ruckelshaus Mary , Salomon Anne K. , Sumaila U. Rashid , White Crow , Naylor Rosamond 
Published: January 2024

AbstractBlue food systems are crucial for meeting global social and environmental goals. Both small-scale marine fisheries (SSFs) and aquaculture contribute to these goals, with SSFs supporting hundreds of millions of people and aquaculture currently expanding in the marine environment. Here we examine the interactions between SSFs and aquaculture, and the possible combined benefits and trade-offs of these interactions, along three pathways: (1) resource access and rights allocation; (2) markets and supply chains; and (3) exposure to and management of risks. Analysis of 46 diverse case studies showcase positive and negative interaction outcomes, often through competition for space or in the marketplace, which are context-dependent and determined by multiple factors, as further corroborated by qualitative modeling. Results of our mixed methods approach underscore the need to anticipate and manage interactions between SSFs and aquaculture deliberately to avoid negative socio-economic and environmental outcomes, promote synergies to enhance food production and other benefits, and ensure equitable benefit distribution.
Single-nanometer CoFeB/MgO magnetic tunnel junctions with high-retention and high-speed capabilities
Authors: Igarashi Junta , Jinnai Butsurin , Watanabe Kyota , Shinoda Takanobu , Funatsu Takuya , Sato Hideo , Fukami Shunsuke , Ohno Hideo 
Published: January 2024

AbstractMaking magnetic tunnel junctions (MTJs) smaller while meeting performance requirements is critical for future electronics with spin-transfer torque magnetoresistive random access memory (STT-MRAM). However, it is challenging in the conventional MTJs using a thin CoFeB free layer capped with an MgO layer because of increasing difficulties in satisfying the required data retention and switching speed at smaller scales. Here we report single-nanometer MTJs using a free layer consisting of CoFeB/MgO multilayers, where the number of CoFeB/MgO interfaces and/or the CoFeB thicknesses are engineered to tailor device performance to applications requiring high-data retention or high-speed capability. We fabricate ultra-small MTJs down to 2.0 nm and show high data retention (over 10 years) and high-speed switching at 10 ns or below in sub-5-nm MTJs. The stack design proposed here proves that ultra-small CoFeB/MgO MTJs hold the potential for high-performance and high-density STT-MRAM.
On the design of cost minimization for D2D‐enabled wireless caching networks: A joint recommendation, caching, and routing perspective
Authors: Hua Yu , Fu Yaru , Zhu Qi 
Published: January 2024

AbstractCache‐enabled device‐to‐device (D2D) network has been deemed as an effective technique to offload the data traffic. However, the gain of the caching schemes is closely related to the homogeneity among users' preference distribution. To tackle this issue, recommendation is a promising proactive approach. It increases the request probability of recommended contents, reshaping users' contents demand patterns, and improving caching performance. Moreover, considering the heterogeneous network settings, i.e. content retrieval costs vary, the routing design becomes a non‐negligible factor on caching performance optimization. On these grounds, the average system cost of D2D‐enabled wireless caching networks with multiple BSs is first described. Then the routing strategies are designed together with caching and recommendation policies by minimizing the average cost of these networks. The optimization problem is proven as NP‐hard. To facilitate the analysis, the original problem is decoupled into two sub‐problems and solve them respectively. Afterwards, all the variables are optimized in an alternating manner until the convergence is achieved. The proposed algorithm's convergence performance and benefits over benchmark strategies in terms of total cost and cache hit ratio are supported by Monte‐Carlo simulation results.
A fully integrated nanosecond burst RF generator for quantum technologies
Authors: Sánchez‐Azqueta Carlos , Aldea Concepción , Celma Santiago 
Published: January 2024

AbstractQuantum technologies is an emerging field of physics and engineering based on exploiting properties of quantum mechanics such as entanglement, superposition, or tunneling, and which is expected to impact many applications, such as communications, simulation, computation, or sensing and metrology. The operation of quantum technologies is based on the manipulation of the quantum states of certain devices, either to induce transitions between states or to detect the transitions. Irrespective of the practical realization of these quantum devices, their manipulation requires interacting with their quantum resonant states, for which very narrow radio‐frequency (RF) bursts in the range of the GHz are required. Arbitrary waveform generators are used to generate these signals for test purposes, but this is not suitable for practical quantum technology applications, which will need to produce the required bursts by specific circuit building blocks with low power and small dimensions. Here, an integrated RF burst generator capable of producing GHz bursts shorter than 1 ns is presented. The proposed architecture is tested using a 5 GHz quadrature LC‐tank voltage‐controlled oscillator (LC‐VCO), showing that the four equally spaced phases can be switched every 500 ps, which allows the generation of more complex RF bursts for optimized quantum state manipulation.
Enhanced trust management for building trustworthy social internet of things network
Authors: Roy Swati Sucharita , Sahu Bharat Jyoti Ranjan , Dash Shatarupa 
Published: January 2024

AbstractInternet of Things (IoT) and wireless communication technologies are evolving rapidly and changing the way we live and work. IoT devices may need to share personal information over the public network taking the help of nearby devices. Thus, the trustworthiness of nearby devices shall play an essential role in providing security and privacy assurance. The authors proposed an autonomous decentralised trust management model for selecting a trustworthy device for a requested service transaction. The proposed scheme uses the Social Internet of Things for trust management. The proposed model uses social relationships to find the level of trust among related devices, estimate the overall trust of the unknown devices, periodically update the observed trust values, and isolate the malicious nodes in the network. The evaluated trust values are updated in the network frequently so that other devices can utilise the information later. The periodic update can increase performance and detect trust‐related malicious attacks. The simulation result shows that the performance of the proposed model is better as compared to existing trust management models. The proposed model can detect malicious objects at an early stage and can handle malicious attacks by isolating malicious devices.
Interdisziplinäre Diagnostik und Therapie von malignen Mesotheliomen
Authors: van der Linde Lea I. S. , Hantzsch-Kuhn Birgit , Ellebrecht David , Stellmacher Florian , Welker Lutz 
Published: January 2024

ZusammenfassungDas asbestbedingte maligne Mesotheliom (MM) gehört in Deutschland mit ca. 1000 Neuerkrankungen pro Jahr zu den häufigen berufsbedingten Krebserkrankungen. Die Diagnose eines MM ist, sofern die entsprechenden diagnostischen Kriterien erfüllt sind, sowohl aus histologischem als auch aus zytologischem Probenmaterial mit hoher Spezifität möglich. Allerdings werden viele MM zyto-/histologisch erst in fortgeschrittenen Stadien entdeckt. Klinisch/radiologische Aspekte ergänzen die Diagnostik und ermöglichen eine interdisziplinäre Beurteilung des Tumorstadiums und individuelle Entscheidungen über die bestmöglichen Therapieoptionen für jeden einzelnen Patienten. Diagnostisch hat die videoassistierte Thorakoskopie (VATS) den höchsten Stellenwert. Die Therapieplanung orientiert sich am vorliegenden MM-Subtyp, der Tumorausbreitung und Stadium sowie dem klinischen Zustand des Patienten. Die Prognose des MM ist im Allgemeinen sehr ungünstig. Dementsprechend zielt die Standardtherapie auf eine makroskopische radikale Tumorresektion im Sinne einer Zytoreduktion im Rahmen eines geeigneten multimodalen Therapiekonzepts (Chemotherapie, Strahlentherapie, Psychoonkologie). Ziel palliativer Maßnahmen sollte v.a. die Symptomkontrolle sein. Insgesamt ist die interdisziplinäre Diagnostik und Therapie des MM entscheidend für die bestmögliche Versorgung der MM-Kranken.
Deep Circumflex Iliac Artery-vascularized Iliac Bone Graft for Femoral Head Osteonecrosis: Computed Tomography Anatomical Study
Authors: He Jiale , Lu Yunxiang , Chen Yuxian , Peng You , Zhu Qi , Li Zhiyong 
Published: January 2024

Abstract
Background Deep circumflex iliac artery (DCIA)-vascularized iliac graft transposition is a method for treating femoral head osteonecrosis but with inconsistent efficacy. We aim to improve the method of this surgery by recommending the optimal location of the iliac pedicle to satisfy the vascular length for transposition and the blood supply of the vascularized iliac graft.
Methods The DCIA and its surrounding tissues were assessed on computed tomography angiography images for 100 sides (left and right) of 50 patients. The length of the vascular pedicle required for transposition and the length of the pedicle at different iliac spine positions were compared. The diameter and cross-sectional area of the DCIA and the distance between the DCIA and iliac spine were measured at different points to assess blood supply. We also compared differences in sex and left–right position.
Results The diameter and cross-sectional area of the DCIA gradually decreased after crossing the anterior superior iliac spine (ASIS), and it approached the iliac bone. However, when the DCIA was 4 cm behind the ASIS (54 sides, 54%), it coursed posteriorly and superiorly away from the iliac spine. The vascular length of the pedicle was insufficient to transpose the vascularized iliac graft to the desired position when it was within 1 cm of the ASIS. The vascular length requirement was satisfied, and the blood supply was sufficient when the pedicle was positioned at 2 or 3 cm.
Conclusion To obtain a satisfactory pedicle length and sufficient blood supply, the DCIA pedicle of the vascularized iliac graft should be placed 2 to 3 cm behind the ASIS. The dissection of DCIA has slight differences in sex and left–right position due to anatomical differences.